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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 4 No. 6 (2014): June 2014
				
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									Review Articles
							
		



	
		  	 

		
	
		“Weak direct” and “Strong indirect” interactions are the mode of action of food factors
	


	
	
		

							
					Authors

						
							
								Tetsuya Konishi
							
															
									NUPALS Liaison R/D Promotion Center, Niigata University of Pharmacy and Applied Life Sciences (NUPALS), International Collaborative Research Laboratory, Changchun University of Chinese Medicine, Changchun
																	
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v4i6.7
						
					
				
			

						
										
					Abstract

					Age-dependent and lifestyle related diseases such as metabolic syndromes have become a social problem worldwide. Since these disorders are closely related to dietary lifestyle, the old saying “foods are medicine” is now being re-evaluated. Thus, dietary protection against these diseases is attracting much attention. As research into functional foods advances, a book of knowledge is being accumulated on the active ingredients, termed “food factors”, present in food resources. Identifying such molecules usually follows the conventional methodology used for finding drug candidates from natural resources. The question has arisen as to whether the mode of action of food factors as molecules is the same as that of drugs. In this article, the functional properties of food factors and drugs are comparatively reviewed and the characteristic features of food factor function is discussed, based on the idea of “weak direct” and “strong indirect” actions of food factors to their receptors.
Keywords: Food factor; Functional models; Weak direct interaction; Strong indirect interaction; Ligand-receptor interaction

				
			
			

						
																			
						
		


		

						
										
					
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						Published
					

					
																			2014-07-25
																	

				
							

			
						
										

											
							
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									Vol. 4 No. 6 (2014): June 2014
								
							

						
					
											
							
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