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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 11 No. 7 (2021): July 2021
				
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									Research Articles
							
		



	
		  	 

		
	
		Effects of the consumption of proanthocyanidins derived from acacia bark on blood pressure in healthy Japanese adults: A randomized, double-blind, placebo-controlled, parallel-group comparison study
	


	
	
		

							
					Authors

						
							
								Asami Baba
							
															
									ORTHOMEDICO Inc.
																	
																																		
	
							
								Tomohiro Hoshino
							
															
									ORTHOMEDICO Inc.
																	
																																		
	
							
								Sosuke Ogawa
							
															
									Acacia-No-Ki Co.,Ltd.
																	
																																		
	
							
								Tsuyoshi Takara
							
															
									Medical Corporation Seishinkai, Takara Clinic
																	
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v11i7.814
						
					
				
			

						
										
					Abstract

					Objective: The aim of this study is to verify the effects of consuming proanthocyanidins derived from acacia bark on improving blood pressure and blood circulation in healthy Japanese adult subjects.
 
Methods: This was a randomized, double-blind, placebo-controlled, parallel-comparison study involving 66 healthy Japanese adults. Subjects were allocated into either acacia or placebo group (n = 33 each) using a random number generator. Subjects consumed six tablets/day of either acacia bark extract tablets or placebo for 12 weeks. The primary outcome was the measured value of sitting systolic blood pressure at 12 weeks, whereas the secondary outcomes were sitting systolic and diastolic blood pressures, superoxide dismutase activity in blood, and blood flow.
Results: The number of subjects analyzed as full analysis set was 33 (20 men and 13 women) in the Acacia group and 31 (23 men and 8 women) in the placebo group. Compared with the placebo group, the measured values and changes from baseline at 4, 8, and 12 weeks of the sitting systolic blood pressure were significantly lower in the Acacia group. Furthermore, “the ratio of the number of subjects whose sitting systolic blood pressure <130 mmHg and diastolic blood pressure ≤89 mmHg at 12 weeks” of the Acacia group was significantly higher than that of the placebo group. No adverse event was observed.
 
Conclusions: Proanthocyanidins derived from acacia bark showed a hypotensive effect.
 
Trial registration: UMIN-CTR: UMIN000039416.
 
Foundation: Acacia-No-Ki Co., Ltd.
 
Keywords: Acacia bark extract, Proanthocyanidins, Systolic blood pressure, Diastolic blood pressure

				
			
			

						
																																								
						
		


		

						
										
					
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						Published
					

					
																			2021-07-16
																	

				
							

			
						
										

											
							
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									Vol. 11 No. 7 (2021): July 2021
								
							

						
					
											
							
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