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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 11 No. 11 (2021): November 2021
				
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									Review Articles
							
		



	
		  	 

		
	
		Functional foods’ bioactive components and their chemoprevention mechanism in cervical, breast, and liver cancers: A systematic review
	


	
	
		

							
					Authors

						
							
								John Oluwafemi Teibo
							
															
									Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP-Brazil.
																	
																																				
																		
										http://orcid.org/0000-0002-0833-4828
									
								
													
	
							
								Kehinde Sulaimon Ayinde
							
															
									Institute of Biology, State University of Campinas, Campinas-SP, Brazil
																	
																																		
	
							
								Olamide Tosin Olaoba
							
															
									Laboratory of Functional and Structural Biochemistry, Federal University of Sao Carlos, SP, Brazil
																	
																																		
	
							
								Temitope Isaac Adelusi
							
															
									Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria
																	
																																		
	
							
								Titilade Kehinde Ayandeyi Teibo
							
																																		
	
							
								Makinde Victor Bamikunle
							
																																		
	
							
								Yomade Ayodeji Jimoh
							
																																		
	
							
								Saad Alghamdi
							
																																		
	
							
								Osama Abdulaziz
							
																																		
	
							
								Abdur Rauf
							
																																		
	
							
								Gaber El-Saber Batiha
							
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v11i11.818
						
					
				
			

						
										
					Abstract

					The invasiveness and low survivability on the part of patients associated with cancer continues to raise global concern. Different approaches have been used in the treatment and restoration of normalcy in cancer patients. However, most of the therapeutic strategies employed are challenged with high cost, low efficacy, high toxicity, and multiple side effects. In recent times, emergent studies have provided evidence that functional foods and their bioactive components serve roles as potential agents in the prevention and treatment of cancers. Moreover, global interest has focused on how this chemoprevention potential of functional foods can be explored as plant-based medicines for drug development. Although, the literature is replete with the mechanism of chemoprevention elicited by individual components of functional foods, there are limited reports on their overall anti-cancer mechanisms. 
Therefore, this systematic review aims to unify the anti-cancer mechanisms of functional foods in cervical, breast, and liver cancers which were selected due to their high incidence and mortality globally. We reviewed articles from NCBI/PUBMED from 2010 until February 2020. Three different search words used include “Functional food and cervical cancer”; “Functional foods and breast cancer”; “Functional foods and hepatocarcinoma”. Consequently, 434 scientific papers resulted from the three search words. However, after applying the inclusion/exclusion criteria, 37 articles were selected: 14 on cervical cancer, 10 on breast cancer, and 13 on hepatocellular carcinoma. We subsequently emphasize the anti-cancer mechanisms of various functional foods in the studies selected and these include induction of apoptosis, cell cycle arrest, disruption of microtubular network, downregulation of anti-apoptotic Bcl-2 family expression, induction of autophagy, modulation of signaling cascades, ROS generation, and suppression of specific genes. Therefore, functional foods possess effective chemoprevention mechanisms which can be explored in drug development.
 
Keywords: Cervical cancer, Breast cancer, Liver cancer, Cancer prevention, Functional foods, Bioactive compounds

				
			
			

						
																																																																																									
						
		


		

						
										
					
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						Published
					

					
																			2021-11-05
																	

				
							

			
						
										

											
							
								Issue
							

							
								
									Vol. 11 No. 11 (2021): November 2021
								
							

						
					
											
							
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								Review Articles
							

						
					
									

			
						
										
					
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