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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 11 No. 9 (2021): September 2021
				
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									Research Articles
							
		



	
		  	 

		
	
		Effect of 12 weeks of continuous burdock sprout extract intake on oxidized LDL: A placebo-controlled, randomized, double-blind, parallel-groups study
	


	
	
		

							
					Authors

						
							
								Naohito Ito
							
															
									Hokkaido Information University
																	
																																		
	
							
								Akiko Ohno
							
															
									R&D Innovation Group, Corporate Planning Division, Kracie Holdings
																	
																																		
	
							
								Satoshi Yomoda
							
															
									R&D Innovation Group, Corporate Planning Division, Kracie Holdings
																	
																																		
	
							
								Satoshi Inamasu
							
															
									R&D Innovation Group, Corporate Planning Division, Kracie Holdings
																	
																																		
	
							
								Hiroki Hattori
							
															
									Hokkaido Information University
																	
																																		
	
							
								Jun Nishihira
							
															
									Hokkaido Information University
																	
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v11i9.820
						
					
				
			

						
										
					Abstract

					Background: Arctigenin, a lignan polyphenol found in burdock sprout, is a potent activator of AMP-activated protein kinase (AMPK) and has beneficial effects on metabolic disorders in mice. This highlights the potential value of arctigenin for the reduction of oxidized LDL (oxLDL) by activation of AMPK in human, but not well elucidated.
Methods: We conducted a placebo-controlled, randomized, double-blind, parallel-groups study in healthy adults to investigate the effects of 12 weeks of a continuous intake of burdock sprout extract enriched with arctigenin on lipid metabolism. The subjects were 100 Japanese individuals with low-density lipoprotein cholesterol (LDL-C) < 140 mg/dl and a body mass index (BMI) of 23–30 kg/m2 who were randomly assigned to receive either burdock sprout extract (test food) or a placebo. The test food was encapsulated burdock sprout extract containing approximately 40 mg of arctigenin equivalent per day, and the placebo capsules contained no burdock sprout extract. The subjects consumed the assigned foods daily for 12 weeks.
Results: The test food significantly suppressed oxLDL after 12 weeks in subjects with a body mass index (BMI) of 25 kg/m2 or higher. The test food inhibited an increase in the FIB-4 index (liver fibrosis index), an indicator of hepatic fibrosis. Pearson’s correlation coefficient analysis revealed a significant correlation between oxLDL and FIB-4 index changes, suggesting that the test food suppressed the rise in the FIB-4 index by controlling oxLDL while maintaining the platelet count.
Conclusions: We conclude that the consumption of a burdock sprout supplement containing arctigenin is effective in suppressing oxLDL, which may prevent liver fibrosis.
Clinical trial registration: UMIN000036664

Keywords: arctigenin, burdock sprout, oxidized LDL, FIB-4 index, randomized controlled study



				
			
			

						
																																																																			
					
													Author Biography
											

						
								
																																							Jun Nishihira,  Hokkaido Information University 
																	

								
									President, Professor
								

							


				
			
						
		


		

						
										
					
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																			2021-09-08
																	

				
							

			
						
										

											
							
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									Vol. 11 No. 9 (2021): September 2021
								
							

						
					
											
							
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								Research Articles
							

						
					
									

			
						
										
					
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