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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 11 No. 9 (2021): September 2021
				
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									Research Articles
							
		



	
		  	 

		
	
		Improvement of glucose metabolism and safety of acacia bark-derived proanthocyanidins in healthy Japanese adults: A Randomized, Double-blind, Placebo-controlled, Parallel-group Trial
	


	
	
		

							
					Authors

						
							
								Asami Baba
							
															
									ORTHOMEDICO Inc.
																	
																																		
	
							
								Tomohiro Hoshino
							
																																		
	
							
								Sosuke Ogawa
							
																																		
	
							
								Tsuyoshi Takara
							
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v11i9.822
						
					
				
			

						
										
					Abstract

					Objective: Acacia bark-derived proanthocyanidins exhibit antioxidant, anti-inflammatory, anti-diabetic, hypotensive effects, and improving skin condition, in addition to beneficial effects on blood glucose. Herein, we evaluated the effects of acacia bark-derived proanthocyanidins on fasting and postprandial blood glucose levels in healthy Japanese adults with fasting blood glucose (FBG) levels between 110–125 mg/dL.
Methods: Subjects were randomly allocated into 2 groups (n = 33 per group) and consumed 6 tablets/day of either tablets of acacia bark extract containing proanthocyanidins (Acacia group) or placebo for 12 weeks. Evaluation points were at the screening, and after 4-week (4w), 8-week (8w), and 12-week intervention (12w). The primary outcome was FBG level at 12 w, whereas the secondary outcomes were FBG level at 4w and 8w, the FBG changes from Scr to each-week intervention, the percentage of subjects with FBG levels below 110 mg/dL after 12 w, the measured value and the change value from Scr to each-week intervention of HbA1c, the measured value and the change value from Scr to each-week intervention of postprandial blood glucose levels.
Results: A total of 33 subjects (18 men, 15 women) from each group were analyzed. The Acacia group had significantly lower FBG levels at 8 and 12 w than the placebo group (P = 0.030 and P = 0.014, respectively). The percentage of subjects with FBG <110 mg/dL at 12 w was marginally higher in the Acacia group than in the placebo group (P = 0.079). HbA1c at 12 w was significantly lowered in the Acacia group compared to the placebo group (P = 0.015).
Conclusions: Acacia bark-derived proanthocyanidins were confirmed to have FBG-lowering effects.
Trial registration: UMIN000039414
Foundation: Acacia-No-Ki Co.,Ltd.
Keywords: Acacia bark extract, Proanthocyanidins, Fasting blood glucose level, HbA1c

				
			
			

						
																																								
						
		


		

						
										
					
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																			2021-09-03
																	

				
							

			
						
										

											
							
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									Vol. 11 No. 9 (2021): September 2021
								
							

						
					
											
							
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