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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 2 No. 7 (2012): July 2012
				
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									Research Articles
							
		



	
		  	 

		
	
		An open-label, randomized clinical trial to assess the immunomodulatory activity of a novel oligosaccharide compound in healthy adults
	


	
	
		

							
					Authors

						
							
								Karriem H. Ali
							
															
									Pharmacognosia, P.O. Box 971, Rainier, WA 98576
																	
																																		
	
							
								Angelica B. Melillo
							
															
									Department of Psychiatry & Behavioral Sciences at University of Miami Miller School of Medicine, 1120 NW 14th Street, Miami, FL 33136
																	
																																		
	
							
								Susanna M. Leonard
							
															
									Department of Psychiatry & Behavioral Sciences at University of Miami Miller School of Medicine, 1120 NW 14th Street, Miami, FL 33136
																	
																																		
	
							
								Deshratn Asthana
							
															
									Department of Psychiatry & Behavioral Sciences at University of Miami Miller School of Medicine, 1120 NW 14th Street, Miami, FL 33136
																	
																																		
	
							
								Judi M. Woolger
							
															
									Department of Medicine at University of Miami Miller School of Medicine, 1120 NW 14th Street, Miami, FL 33136
																	
																																		
	
							
								Aaron H. Wolfson
							
															
									Department of Radiation Oncology at University of Miami Miller School of Medicine, 1120 NW 14th Street, Miami, FL 33136
																	
																																		
	
							
								H. McDaniel
							
															
									Fisher Institute for Medical Research, 2701 Osler Dr Suite 6B Grand Prairie, TX 75051
																	
																																		
	
							
								John E. Lewis
							
															
									Department of Psychiatry & Behavioral Sciences at University of Miami Miller School of Medicine, 1120 NW 14th Street, Miami, FL 33136
																	
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v2i7.84
						
					
				
			

						
										
					Abstract

					Background: Rice Bran Arabinoxylan Compound (RBAC) is a nutritional supplement produced by enzymatic hydrolysis of hemicellulose B derived from rice bran. Several in vitro studies and clinical reports have shown RBAC to possess promising immunomodulating effects, specifically with respect to natural killer cell and cytokine activity. The concept of a true immunomodulator is an agent possessing a broad range of activity dependent upon the existing state of health and immunity in the individual host. The present study investigated the immunomodulatory effect of RBAC in a healthy adult human population over 60 days by assessing changes in natural killer cell cytotoxicity (NKCC) and cytokines and growth factors. Subjects participated in a two-group, randomized intervention, where one group (n=10) consumed 1 gram/day and the other (n=10) consumed 3 gram/day. Safety and tolerability of RBAC were assessed with total bilirubin, total protein, creatinine, and liver function tests.
Results: We found that both groups had similar responses for NKCC, cytokines, and growth factors. The NKCC peaked at 1 week, whereas interferon-γ, tumor necrosis factor-α, interleukins-1α, -1β, -8, and -10, and epidermal growth factor peaked at 30 days. All subjects tolerated the supplement without any adverse reactions.

Conclusions: Our results showed transient, bi-directional, immune marker effects consistent with true, multifactorial immunomodulation rather than simply immunostimulation or immunosuppression. Given our findings, the immunomodulatory activity of RBAC merits study in conditions where the immune system is functionally compromised (e.g., otherwise-healthy smokers and HIV/AIDS or cancer patients). RBAC may not only help to destroy tumor cells and viruses directly, but also increase the activity of immune cells, thereby optimizing the immune system, especially NKCC, which can increase the chance and speed of host recovery.

Keywords: Rice bran, arabinoxylan compound, activity of immune cells, immunomodulation, HIV/AIDS, and cancer

				
			
			

						
																																																																				
						
		


		

						
										
					
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						Published
					

					
																			2012-07-28
																	

				
							

			
						
										

											
							
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									Vol. 2 No. 7 (2012): July 2012
								
							

						
					
											
							
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								Research Articles
							

						
					
									

			
						
										
					
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