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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 12 No. 1 (2022): January 2022
				
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									Research Articles
							
		



	
		  	 

		
	
		Correction of metabolic disturbances by functional food compositions in experimental obesity in CD-1 and agouti-yellow mice
	


	
	
		

							
					Authors

						
							
								Petr Lebedev
							
																																		
	
							
								Anna Peresypkina
							
															
									Belgorod State National Research University
																	
																																				
																		
										https://orcid.org/0000-0003-2829-9860
									
								
													
	
							
								Vasiliy Gustinovich
							
																																		
	
							
								Oleg Godunov
							
																																		
	
							
								Vladimir Gustinovich
							
																																		
	
							
								Maria Zatolokina
							
																																		
	
							
								Artem Goliusov
							
																																		
	
							
								Mikhail Pokrovskii
							
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v12i1.874
						
					
				
			

						
										
					Abstract

					Background: To determine the most promising composition, the possibility of correction of metabolic disturbances was investigated with the use of functional food compositions in CD1 and agouti-yellow mice in experimental obesity.
Methods: Agouti-yellow and CD1 mice were divided into 10 groups (control, 1/1, 1/9, 2/1, 2/9 in each line) according to diets. For 4 weeks, the groups ate a high-calorie diet. Starting with week 5th, composition 1 was added to the diet in groups 1/1 (60% lard + 39% standard laboratory feed + 1% composition 1 + 10% fructose solution), 1/9 (60% lard + 31% standard laboratory feed + 9% composition 1 + 10% fructose solution); composition 2 was added to the diet in groups 2/1 (60% lard + 39% standard laboratory feed + 1% composition 2 + 10% fructose solution), 2/9 (60% lard + 39% standard laboratory feed + 9% composition 2 + 10% fructose solution). On the day 56th, each animal was weighed, blood was taken for biochemical analysis (glucose, LDL, cholesterol and HDL) and organs (the skin of the anterior abdominal wall, skeletal muscle tissue in the area of the lateral surface of the thigh, liver, kidneys with perirenal tissue, pancreas, and thymus) were taken for histological examination.
Results: In agouti-yellow mice, group 2/9, the greatest decrease in blood glucose level was observed compared to the control group by 34.6% (p < 0.05). Consumption of compositions in groups 1/9 and 2/9 led to a significant decrease in LDL and a significant decrease in total cholesterol level by 21.9% (p < 0.05) and 18.8% (p < 0.05) respectively compared to the control group. HDL was significantly higher in groups 1/9, 2/9 than in the control group. In CD-1 mice, group 2/9 showed the best result in glucose level (mean 5.78 mmol/l) among all groups receiving functional food compositions and the control group. The most pronounced decrease in LDL was observed in groups 1/9, 2/9 compared to the control group (p < 0.05). HDL value in group 2/9 significantly exceeded the mean value in the control group, by 54.8% (p < 0.05). Body mass of agouti-yellow mice and CD-1 mice in groups 1/1, 2/1, 1/9, and 2/9 significantly decreased compared to control groups. According to the results of histological examination of organs and tissues, functional food composition 2 turned out to be the most promising.
Conclusion: According to the results of the study, the most promising composition was selected (composition 2). Feeding animals with this composition improved histological pictures of studied organs and tissues, biochemical blood parameters and effectively reduced body mass in both experimental animal lines, CD-1, and agouti-yellow mice, compared to the control groups.
 
Keywords: CD-1 mice, agouti-yellow mice, experimental obesity, LDL, cholesterol
				
			
			

						
																																																																																	
					
													Author Biography
											

						
								
																																							Anna Peresypkina,  Belgorod State National Research University 
																	

								
									Профессор кафедры фармакологии и клинической фармакологии Института медицины Белгородского государственного национального исследовательского университета
								

							


				
			
						
		


		

						
										
					
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						Published
					

					
																			2022-01-17
																	

				
							

			
						
										

											
							
								Issue
							

							
								
									Vol. 12 No. 1 (2022): January 2022
								
							

						
					
											
							
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								Research Articles
							

						
					
									

			
						
										
					
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