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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 2 No. 6 (2012): June 2012
				
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									Research Articles
							
		



	
		  	 

		
	
		Phenotype microarray profiling of the antibacterial activity of red cabbage
	


	
	
		

							
					Authors

						
							
								F. Abu Bakar
							
															
									Insititute of Bioscience, University Putra Malaysia, Serdang
																	
																																		
	
							
								R. R. Hafidh
							
															
									Microbiology Department, College of Medicine, Baghdad University
																	
																																		
	
							
								A. S. Abdulamir
							
															
									Insititute of Bioscience, University Putra Malaysia, Serdang
																	
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v2i6.88
						
					
				
			

						
										
					Abstract

					Background: Functional food can be a potent source of wide array of biocomonents with antimicrobial activity. We investigated the antibacterial activity of red cabbage (RC) extract on Gram negative and positive ATCC strains. Most intersting, we, for the first time, explored and analysed the complete phenotypic profile of RC-treated bacteria using Omnilog Phenotype Microarray.
Results: This study revealed that the phenotype microarray (PM) screen was a valuable tool in the search for compounds and their antibacterial mechanisms that can inhibit bacterial growth by affecting certain metabolic pathways. It was shown that RC exerted remarkable antibacterial effect on S. aureus and E. coli bacteria, and PM showed a wide range phenotypic profile of the exerted RC antibacterial activity. RC targeted the peptide, carbon, nutriontional assembly, and sulfur metbolic pathways altogether. The peptidoglycan synthesis pathway was inferred to be targeted by RC extract at a metabolic point different from other available cell wall-targeting drugs; these could be hot targets for the discovery of new therapy for many problematic microbes.
Conclusions: Taken together, the phenotype microarray for functional food and medicinal plants can be a very useful tool for profiling their antimicrobial activity. Moreover, extracts of functional food can exert antibacterial activity by hitting a wide range of metabolic pathways, at the same time leading to very difficult condition for bacteria to rapidly develop resistance. Therefore, using functional foods or medicinal plants as such, or as extracts, can be superior on mono-targeting antibiotics if the optimal concentrations and conditions of these functional foods were sought.
Key words: red cabbage, bacteria, antibacterial, phenotype microarray, Omnilog, Biolog

				
			
			

						
																																	
						
		


		

						
										
					
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																			2012-06-14
																	

				
							

			
						
										

											
							
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									Vol. 2 No. 6 (2012): June 2012
								
							

						
					
											
							
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								Research Articles
							

						
					
									

			
						
										
					
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