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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 12 No. 3 (2022): March 2022
				
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									Research Articles
							
		



	
		  	 

		
	
		Effect of Raphanus sativus on Glucose, Cholesterol and Triglycerides Levels in Glucose Loaded Rats
	


	
	
		

							
					Authors

						
							
								Rehab Omer Elnour
							
																																		
	
							
								Omar Musa EzzEldin
							
																																		
	
							
								Abdalbasit Adam Mariod
							
																																		
	
							
								Reem Hassan Ahmed
							
																																		
	
							
								Ahlam Salih Eltahir
							
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v12i3.883
						
					
				
			

						
										
					Abstract

					Background: In fact, diabetes is now a serious health concern, and the import of medications from other countries consumes a significant amount of foreign cash each year. The effects of Raphanus satives (Radish) in the treatment of diabetes mellitus were evaluated scientifically in this study. Thyroid hormone increases metabolic actions in almost every tissue, and the current study was an attempt to evaluate scientifically the effects of Raphanus satives (Radish) in the treatment of diabetes mellitus.
Objectives: The main objective of this study is to evaluate the hypoglycemic effect of Raphanus sativus (Radish) on induced hyperglycemic rats.
Methods: An oral administration of ethanolic extract of Radish in glucose loaded rats at dose of 250mg/k body weight,  standard group was administered with 10mg/kg of hypoglycemic drug glibenclamide for 2 consecutive weeks. The control group was given distilled water only. After the two weeks' time, the groups were subjected to a glucose tolerance test and measurement of plasma cholesterol and triglyceride levels. 
Results: significant reduction of blood glucose was observed (P <0.001), when compared with the control group at 2 hours after glucose loud. Radish ethanolic extract did not present any significant difference in cholesterol level after 2 weeks compared with start point. No significant difference was seen in triglyceride level after 2 weeks of administration of Radish extract compared with start point. Radish extract(250 mg/kg) did not affect kidney function  creatinin and urea, also liver  function were not affected Glutamic-Oxaloacetic Transaminase (GOT), Glutamic-Pyruvate Transaminase (GPT), albumin, total protein and bilirubin, this means administration of increased doses to hyperglycemic subjects can be considered safe. 
CONCLUSION: In this investigation, doses of radish extract (250 mg/kg) had no effect on renal function, creatinin, and urea, as well as liver function. Glutamic-Oxaloacetic Transaminase (GOT), Glutamic-Pyruvate Transaminase (GPT), albumin, total protein, and bilirubin .

Keywords: Raphanus sativus, extract, hypoglycemic, glucose, rats 

				
			
			

						
																																															
						
		


		

						
										
					
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																			2022-03-25
																	

				
							

			
						
										

											
							
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									Vol. 12 No. 3 (2022): March 2022
								
							

						
					
											
							
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								Research Articles
							

						
					
									

			
						
										
					
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