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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 12 No. 2 (2022): February 2022
				
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									Research Articles
							
		



	
		  	 

		
	
		Suppression of blood glucose level elevation and promotion of  GLP-1 secretion by ingestion of Undaria pinnatifida sporophylls (Mekabu): Open-label crossover design
	


	
	
		

							
					Authors

						
							
								Shiori Takano
							
															
									Faculty of Human Ecology, Wayo Women’s University
																	
																																		
	
							
								Kazuma Yoshizumi
							
															
									Kaneryo Sea Vegetable Corporation
																	
																																		
	
							
								Hitomi Kobayashi
							
															
									Faculty of Human Nutrition, Seitoku University
																	
																																		
	
							
								Naoki Iwamoto
							
															
									Faculty of Contemporary Human Life Science, Tokyo Kasei Gakuin University
																	
																																		
	
							
								Masaki Taga
							
															
									Faculty of Human Ecology, Wayo Women’s University
																	
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v12i2.891
						
					
				
			

						
										
					Abstract

					Background: It has been confirmed that the daily consumption of seaweed such as Wakame (Undaria pinnatifida) and Kombu (Saccharina japonica) has an inhibitory effect on the rise in postprandial blood glucose levels. Similar effects can also be expected for Mekabu, which is Wakame sporophylls and contains large quantities of water-soluble dietary fiber. In this study, we examined the effects of preprandial intake of Mekabu on postprandial blood glucose levels and blood glucose regulation-related hormones in healthy young women.
Methods: The subjects were ten healthy young adult women. Mekabu was eaten, followed by rice only. Blood was sampled five times: while fasting (0 min), and 15, 30, 90, and 120 minutes after eating. Measurements were taken of blood glucose level and blood glucose regulation-related hormones.
Result: Eating Mekabu before rice resulted in a significant reduction of Δglucose and Δinsulin at 30 minutes after ingestion (p = 0.034, p = 0.049, respectively). The concentration of glucagon-like peptide-1 (GLP-1) in plasma was higher 30 minutes after eating (p = 0.044), 60 minutes (p = 0.0.31), and 120 minutes (p = 0.019) when Mekabu was eaten preprandially.
Conclusions: In the present study, GLP-1 secretion was sustained by eating Mekabu, which is Wakame sporophylls, before rice. Our results suggest that ingesting Mekabu, which contains large amounts of viscous alginic acid, prior to a meal not only suppresses postprandial blood glucose level, but supports the extended secretion of GLP-1, providing a sustainable incretin effect.

Keywords: mekabu (Undaria pinnatifida sporophylls), blood glucose, glucagon-like peptide-1 (GLP-1), insulin, incretin, water-soluble dietary fiber

				
			
			

						
																																															
						
		


		

						
										
					
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																			2022-02-16
																	

				
							

			
						
										

											
							
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									Vol. 12 No. 2 (2022): February 2022
								
							

						
					
											
							
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