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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 12 No. 3 (2022): March 2022
				
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									Research Articles
							
		



	
		  	 

		
	
		Anti-allergic activity of an ethanol extract of bunching onion (Allium fistulosum), a traditional vegetable from Osaka
	


	
	
		

							
					Authors

						
							
								Tomoko Jippo
							
															
									Department of Food and Nutrition, Faculty of Human Life Sciences, Senri Kinran University
																	
																																		
	
							
								Yuko Kobayashi
							
															
									Department of Food and Nutrition, Faculty of Human Life Sciences, Senri Kinran University
																	
																																		
	
							
								Kosuke Kitada
							
															
									Research Institute of Environment, Agriculture and Fisheries, Osaka Prefecture
																	
																																		
	
							
								Koji Kitsuda
							
															
									Research Institute of Environment, Agriculture and Fisheries, Osaka Prefecture
																	
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v12i3.900
						
					
				
			

						
										
					Abstract

					Introduction: The incidences of allergic diseases such as allergic rhinitis, atopic dermatitis, asthma, and food allergies are rising in developed countries. Mast cells play critical roles in various biologic processes related to allergic diseases, including expressing the high-affinity receptor for immunoglobulin (Ig) E on their surface. The interaction of multivalent antigens with surface-bound IgE causes the secretion of granule-stored mediators, as well as the de novo synthesis of cytokines. These mediators and cytokines precede the development of allergic diseases. In Osaka Prefecture, Japan, certain locally cultivated crops have received ‘Naniwa-yasai’, a designation that certifies the significance of traditional vegetables in supporting Osaka’s agriculture and cuisine for over a century. In this study, we investigated the anti-allergic effects of four traditional vegetables from Osaka.


Results: The anti-allergic activity of extracts made from Tanabe radish, Moriguchi radish, bunching onion (Allium fistulosum), and mizu eggplant were examined. Various concentrations of each extract were added to RBL-2H3 mast cells prior to stimulation with the calcium ionophore A23187. β-hexosaminidase release was markedly and dose dependently decreased in mast cells following the addition of A. fistulosum, demonstrating its anti-allergic activity. None of the other vegetables had an anti-allergic effect on RBL-2H3 cells.


Conclusion: An Osakan traditional vegetable, bunching onion (Allium fistulosum), exhibited anti-allergic activity, and should be explored further as a possible treatment for allergic diseases.

Keywords: mast cell, anti-allergy, traditional vegetables, bunching onion (Allium fistulosum)



				
			
			

						
																																																					
					
													Author Biography
											

						
								
																																							Tomoko Jippo,  Department of Food and Nutrition, Faculty of Human Life Sciences, Senri Kinran University 
																	

								
									Department of Food and Nutrition, Faculty of Human Life Sciences, Senri Kinran University,
								

							


				
			
						
		


		

						
										
					
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																			2022-03-15
																	

				
							

			
						
										

											
							
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									Vol. 12 No. 3 (2022): March 2022
								
							

						
					
											
							
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								Research Articles
							

						
					
									

			
						
										
					
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