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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 12 No. 9 (2022): September 2022
				
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									Research Articles
							
		



	
		  	 

		
	
		Corozo (Bactris guineensis) fruit extract has antiviral activity in vitro against SARS-CoV-2
	


	
	
		

							
					Authors

						
							
								Tania Jaimes-Gualdrón
							
															
									Laboratorio Ciencia de los Alimentos, Universidad Nacional de Colombia Sede Medellín, Colombia
																	
																																		
	
							
								Lizdany Flórez-Álvarez
							
															
									Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia UdeA, Medellín, Colombia
																	
																																		
	
							
								María Isabel Zapata-Cardona
							
															
									Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia UdeA, Medellín, Colombia
																	
																																		
	
							
								Benjamín Alberto Rojano
							
															
									Laboratorio Ciencia de los Alimentos, Universidad Nacional de Colombia Sede Medellín, Colombia.
																	
																																		
	
							
								María Teresa Rugeles
							
															
									Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia UdeA, Medellín, Colombia
																	
																																		
	
							
								Wildeman Zapata-Builes
							
															
									Grupo Infettare, Facultad de Medicina, Universidad Cooperativa de Colombia, Medellín, Colombia
																	
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v12i9.918
						
					
				
			

						
										
					Abstract

					Background: Given the current COVID-19 pandemic, numerous drug development studies are being carried out for the treatment and control of this disease. This study aimed to evaluate the in vitro antiviral potential of Corozo fruit extract (Bactris guineensis) against SARS-CoV-2.
Methods: Corozo extract (CE) was prepared from the pulp of mature Corozo fruits. The total content of phenols, flavonoids, and anthocyanins in the extracts was determined using the Folin-Ciocalteu, aluminum chloride, and pH differential methods, respectively. The cytotoxicity on Vero E6 cells was evaluated by MTT assay. Antiviral activity was evaluated by pre-post-treatment using a Colombian isolate of SARS-CoV-2. Viral titer was quantified by plaque assay.
Results: Anthocyanin concentration of CE was 144.95 ± 10.3 mg cyanidin-3-glucoside/L. The cytotoxicity of CE on Vero E6 was lower to 20 % at 15.6 g/L. Corozo extract inhibited SARS-CoV-2 at 15.6, 7.8, 3.9 and 1.9 g/L with inhibition percentages of 88.2%, 84%, 59.6% and 56.3%, respectively.
Conclusion: This is the first report on the in vitro antiviral effect of Corozo fruit extract against SARS-CoV-2. Since this is a natural product, proven safe for consumption, in the future and with further studies, it could be considered an important functional food that can be useful in preventing strategies to fight against COVID-19.

Keywords: Bactris guineensis, Corozo fruit, antiviral activity, SARS-CoV-2, COVID-19.



				
			
			

						
																																																						
						
		


		

						
										
					
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																			2022-09-15
																	

				
							

			
						
										

											
							
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									Vol. 12 No. 9 (2022): September 2022
								
							

						
					
											
							
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								Research Articles
							

						
					
									

			
						
										
					
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