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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 12 No. 6 (2022): June 2022
				
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									Research Articles
							
		



	
		  	 

		
	
		Nutritional and anti-gastro ulcerative role of the gum Arabic (Acacia senegal L.) compared to a reference drug
	


	
	
		

							
					Authors

						
							
								Qaswaa Yousif Jameel
							
															
									Department of Food Science, Colleges of Agricultural and Forestry, University of Mosul, Mosul, Iraq
																	
																																		
	
							
								Mohammed Abdullah Ajeel
							
															
									Colleges of Pharmacy, University of Mosul, Mosul, Iraq
																	
																																		
	
							
								Nameer Khairullah Mohammed
							
															
									Department of Food Science, College of Agriculture, Tikrit University 3400, Tikrit, Iraq
																	
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v12i6.929
						
					
				
			

						
										
					Abstract

					Background: As alcohol consumption increases, ethanol impacts ulcers as a factor that causes stomach mucosal invasion, which leads to stomach ulcers. Alcohol damages the stomach through a number of processes, including increased gastric secretion, the release of pro-inflammatory cytokines, and ethanol induces a variety of pathogenic events as it is associated with the formation of stomach ulcers.
Objective: The goal of this study was to see if gum Arabic as a functional food could protect albino rats against ethanol-induced stomach damage.
Materials and Methods: Six groups of 30 female albino rats were formed: normal control, ulcer control, omeprazole + ethanol, and groups 4, 5, and 6, which were given GA at 7.5, 12, 25 g/ kg/ day (bw), then lab rat were given 5 mL/kg /day (bw) ethanol orally for 30 days to cause stomach mucosal damage.
Results: GA suppressed gastric inflammation by lowering TNF-α and IL-6 levels while increasing IL-10 levels. GA also improved HDL, total protein, albumin, and globulin levels while lowering cholesterol, triglycerides, VLDL-C, LDL-C, and phospholipids.
Conclusion: These findings demonstrate that GA plays a protective role toward gastric mucosal injury in rats induced by ethanol, which in turn reduced the inflammatory response, and significantly reduced the hemorrhagic gastric lesions and the pH of the gastric contents.
 
Keywords: Functional food, Alcoholic, polysaccharides, soluble fiber, tumor necrosis factor alpha, oxidative stress
 

				
			
			

						
																																	
						
		


		

						
										
					
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																			2022-06-23
																	

				
							

			
						
										

											
							
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									Vol. 12 No. 6 (2022): June 2022
								
							

						
					
											
							
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								Research Articles
							

						
					
									

			
						
										
					
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