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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 12 No. 6 (2022): June 2022
				
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									Research Articles
							
		



	
		  	 

		
	
		Beneficial effects of gymnemic acid on three-dimensional vascular architecture and expression of vascular endothelial growth factor of intrarenal segmental and interlobar arteries in diabetic rat kidney
	


	
	
		

							
					Authors

						
							
								Manaras Komolkriengkrai
							
															
									Division of Health and Applied Sciences
Faculty of Science
Prince of Songkla University
Thailand
																	
																																		
	
							
								Rawipa Jangchart
							
															
									Division of Health and Applied Sciences
Faculty of Science
Prince of Songkla University
Thailand
																	
																																		
	
							
								Nichawadee Sandech
							
															
									Division of Health and Applied Sciences
Faculty of Science
Prince of Songkla University
Thailand
																	
																																		
	
							
								Uraporn Vongvatcharanon
							
															
									Division of Health and Applied Sciences
Faculty of Science
Prince of Songkla University
Thailand
																	
																																		
	
							
								Wipapan Khimmaktong
							
															
									Division of Health and Applied Sciences
Faculty of Science
Prince of Songkla University
Thailand
																	
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v12i6.930
						
					
				
			

						
										
					Abstract

					Background: A high prevalence of atherosclerotic vascular lesions has been associated with renal disease and diabetes and is a major cause for increasing deaths from cardiovascular disease. The present study aimed to determine the beneficial effects of gymnemic acids on the kidney microvasculature and to establish their anti-angiogenic properties that are related to the expression of vascular endothelial growth factor (VEGF) protein of segmental and interlobar arteries in induced diabetic rats. 
Methods: Rats were divided into five groups including the control group (C), control treated with gymnemic acid (CGM), diabetic animals (DM group) that were rendered diabetic by a single dose [60 mg/kg body weight (BW)] of a streptozotocin (STZ) injection, diabetic rats treated with gymnemic acid (400 mg/kg BW) (GM), and diabetic rats treated with glibenclamide (4 mg/kg BW) (GR). After 8 weeks, kidney tissues were collected for histological analysis. In rats with DM, the segmental arteries exhibited increased wall thickness. The kidney microvasculature was examined using the vascular corrosion casting method. 
Results: Rats with DM presented a decreasing diameter of segmental and interlobar arteries. They were evidently redeveloped and restored in the GM and GR groups. As determined by immunofluorescence, the expression of VEGF was significantly reduced in both the GM and GR groups. 
Conclusions: The present study demonstrated that gymnemic acid from Gymnemasylvestre may be a promising medical herb for use in the treatment of diabetes and kidney disease.

Keywords: diabetes mellitus, segmental artery, interlobar artery, gymnemic acid, vascular architecture


				
			
			

						
																																																												
					
													Author Biography
											

						
								
																																							Wipapan Khimmaktong,  Division of Health and Applied Sciences
Faculty of Science
Prince of Songkla University
Thailand 
																	

								
									Division of Health and Applied Sciences
Faculty of Science
Prince of Songkla University
Thailand

								

							


				
			
						
		


		

						
										
					
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																			2022-06-22
																	

				
							

			
						
										

											
							
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									Vol. 12 No. 6 (2022): June 2022
								
							

						
					
											
							
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								Research Articles
							

						
					
									

			
						
										
					
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