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							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 12 No. 12 (2022): December 2022
				
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									Research Articles
							
		



	
		  	 

		
	
		Preclinical study of goat milk kefir as an antihyperglycemic food
	


	
	
		

							
					Authors

						
							
								Siti Susanti
							
															
									Food Technology, Department of Agriculture, Faculty of Animal Sciences and Agriculture, Diponegoro University, Semarang, Indonesia
																	
																																		
	
							
								Nurwantoro Nurwantoro
							
															
									Food Technology, Department of Agriculture, Faculty of Animal Sciences and Agriculture, Diponegoro University, Semarang, Indonesia
																	
																																		
	
							
								Jessen Juan Elto
							
															
									Food Technology, Department of Agriculture, Faculty of Animal Sciences and Agriculture, Diponegoro University, Semarang, Indonesia
																	
																																		
	
							
								Trilaksana Nugroho
							
															
									Faculty of Medicine, Diponegoro University, Semarang, Indonesia
																	
																																		
	
							
								Ade Erma Suryani
							
															
									Research Center for Food Technology and Processing-National Research and Innovation Agenc
																	
																																		
	
							
								Heni Rizqiati
							
															
									Food Technology, Department of Agriculture, Faculty of Animal Sciences and Agriculture, Diponegoro University, Semarang, Indonesia
																	
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v12i12.987
						
					
				
			

						
										
					Abstract

					Background: Goat milk kefir is a functional food with numerous health benefits, including blood sugar control, cholesterol reduction, and improved digestive health. This study aims to determine the effect of kefir consumption on blood glucose levels in hyperglycaemic mice (Mus musculus) without affecting another blood chemistry.  This study compared goat milk kefir products to other processed milk products considered to be capable of controlling and reducing blood sugar levels. 
Objective:This study aimed to compare goat milk kefir products to other processed food products considered to be capable of controlling and reducing blood sugar levels.
Methods: Twenty-one mice, as experimental animals, were induced for 21 days with the high-fat and high fructose diet to increase blood sugar levels. After induction, mice were divided into 3 groups according to treatment, namely oral administration of additional distilled water (placebo), diabetasol® (positive control), and goat's milk kefir with each group consisting of 9 individuals. 
Results: Treatment showed significant effect on the blood glucose and β-ketone level. Diabetasol®  and Goat kefir supplemented mice had a lower blood glucose level than control (p < 0.05) and goat kefir supplemented mice had lower blood β-ketone level than control and Diabetasol® (p< 0.05). Meanwhile, hematocrit and hemoglobin levels did not show significant differences between treatments.
Conclusion: The results suggested that goat milk kefir has preclinical potential as an antihyperglycemic functional food without affecting other blood chemistry profiles.

Keywords: Antihyperglycemic, blood sugar, goat kefir

				
			
			

						
																																																						
						
		


		

						
										
					
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																			2022-12-08
																	

				
							

			
						
										

											
							
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									Vol. 12 No. 12 (2022): December 2022
								
							

						
					
											
							
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								Research Articles
							

						
					
									

			
						
										
					
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