Effects of Nut Consumption on Cardiovascular Risk Factors and Coronary Heart Diseases | Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Skip to main content Skip to main navigation menu Skip to site footer Open Menu Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Home Food Science Publisher Functional Food Center Current Archives About About the Journal Aims and Scope Contact Editing Services Editorial Team Express Peer Review Graphical Abstract Journal Insights Privacy Statement Submissions Announcements Search Search Register Login Home / Archives / Vol. 12 No. 11 (2022): November 2022 / Review Articles Effects of Nut Consumption on Cardiovascular Risk Factors and Coronary Heart Diseases Authors Mohammad Javad Zibaeenezhad Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Zahra Elyaspour Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran https://orcid.org/0000-0001-5329-6667 DOI: https://doi.org/10.31989/ffhd.v12i11.1022 Abstract Background: Intervention and epidemiological studies have shown that nut consumption has beneficial effects on cardiovascular risk factors, such as hypertension, type 2 diabetes, body mass index, and hyperlipidemia. The aim of this review is to investigate the effects of nut consumption on cardiovascular risk factors and coronary heart diseases. In addition, we investigated possible mediating mechanisms through which nuts act with health protective effects, which could have a preventive effect on cardiovascular risk factors and coronary artery diseases. Method: We collected accredited international investigations, whether original, review, meta-analysis that published data in Google Scholar, PubMed/Medline, Wiley Online Library, Web of Science, Science Direct, Scopus, and Research Gate databases. Result:Some human studies and most animal and laboratory studies reported that favorable effects of nut consumption on cardiovascular risk factors and diseases are through their nutrient profile including polyphenols, unsaturated fatty acid, vitamins, phytosterols, minerals, fibers, and protein. Nut nutrient profile could act through reduction inflammation, inhibition oxidative stress, gut microbiota modification, improvement of endothelial function, modulating gene expression, miRNA, adipokines, insulin secretion, lipid and glucose metabolism, and decreasing cholesterol absorption. Conclusion:Nuts have favorably acted on lipid profile, glucose homeostasis, vascular health, and weight control. Furthermore, human clinical trials are needed to find the exact and most effective pathways by which nuts prevent or reduce cardiovascular risk factors. Keywords: Nut Consumption, hypertension, type 2 diabetes, body mass index, hyperlipidemia Author Biographies Mohammad Javad Zibaeenezhad, Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Zahra Elyaspour, Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Downloads [Abstract] [Full Article] Published 2022-11-17 Issue Vol. 12 No. 11 (2022): November 2022 Section Review Articles License Authors retain the copyright of their articles and grant the Functional Food Center (FFC) and its journals the right of first publication under the terms of the Creative Commons Attribution 4.0 International License. This license permits unrestricted use, distribution, and reproduction in any medium, including commercial use, provided the original author(s) and source are properly credited. Authors may post and share their published work freely, provided that the original publication in this journal is acknowledged. By submitting to this journal, authors confirm that their manuscripts are original, not under consideration elsewhere, and that they hold the necessary rights to grant this license. The Functional Food Center encourages open scientific exchange and allows derivative and extended works, provided attribution to the original publication is maintained. About the Journal      Editing Services      Graphical Abstract      Journal Insights        Submissions        Editorial Team       Privacy Statement        Contact        Current        Archives   Open Journal Systems Hosting and Support by: OpenJournalSystems.com