The Enhancing Effect of γ-Cyclodextrin Inclusion on γ-Tocotrienol-dependent Negative Growth Control of Mesothelioma Cells in a Xenograft Model | Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Skip to main content Skip to main navigation menu Skip to site footer Open Menu Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Home Food Science Publisher Functional Food Center Current Archives About About the Journal Aims and Scope Contact Editing Services Editorial Team Express Peer Review Graphical Abstract Journal Insights Privacy Statement Submissions Announcements Search Search Register Login Home / Archives / Vol. 1 No. 12 (2011): December 2011 / Short Report The Enhancing Effect of γ-Cyclodextrin Inclusion on γ-Tocotrienol-dependent Negative Growth Control of Mesothelioma Cells in a Xenograft Model Authors T. Yano Research Group of Nutritional Sciences, Faculty of Life Sciences, Toyo University, Gunma, 374-0193 A. Sato Research Group of Nutritional Sciences, Faculty of Life Sciences, Toyo University, Gunma, 374-0193 M. Sekine Research Group of Nutritional Sciences, Faculty of Life Sciences, Toyo University, Gunma, 374-0193 K. Kashiwagi Department of Experimental Pathology, Yokohama City University Graduate School of Medicine, Kanagawa, 315-0345 M. Ota Research Group of Nutritional Sciences, Faculty of Life Sciences, Toyo University, Gunma, 374-0193 DOI: https://doi.org/10.31989/ffhd.v1i12.110 Abstract Background: Malignant mesothelioma is an aggressive cancer with no effective treatment options. Of phytochemicals, tocotrienol (T3), a member of vitamin E, is one of the most potent anti-mesothelioma agents, but the effectiveness in vivo is quite limited, due to its low bioavailability. In this study, we investigated if the oral treatment of γ-T3 inclusion with γ-cyclodextrin (CD) could improve the bioavailability and anticancer activity of the T3. Findings: Using nude mice bearing MSTO-211H cells (a human malignant mesothelioma cell line), the effect of γ-T3 inclusion with γ-CD on γ-T3 level in tumor tissues, tumor growth, and its related mRNA levels were examined. The difference of tumor growth between the two groups had no statistical significance, but the latter showed a lower tendency compared with the former. In linked with this observation, the level of vascular endothelial growth factor mRNA required for in vivo tumor growth in γ-T3 inclusion with γ-CD group was lower than that in γ-T3 group, on the contrary, the level of γ-T3 level showed an opposite tendency. Conclusion: Our study demonstrated that the bioavailability of γ-T3 was improved by an oral administration of a novel γ-T3 inclusion complex with CD. Furthermore, the improvement of the bioavailability contributed to the increase of anticancer activity of γ-T3 in vivo. Keywords: Anti-cancer agent, bioavailability, cyclodextrin, mesothelioma, tocotrienol. Downloads [Abstract] [Full Article] Published 2011-12-30 Issue Vol. 1 No. 12 (2011): December 2011 Section Short Report License Authors retain the copyright of their articles and grant the Functional Food Center (FFC) and its journals the right of first publication under the terms of the Creative Commons Attribution 4.0 International License. This license permits unrestricted use, distribution, and reproduction in any medium, including commercial use, provided the original author(s) and source are properly credited. Authors may post and share their published work freely, provided that the original publication in this journal is acknowledged. By submitting to this journal, authors confirm that their manuscripts are original, not under consideration elsewhere, and that they hold the necessary rights to grant this license. The Functional Food Center encourages open scientific exchange and allows derivative and extended works, provided attribution to the original publication is maintained. About the Journal      Editing Services      Graphical Abstract      Journal Insights        Submissions        Editorial Team       Privacy Statement        Contact        Current        Archives   Open Journal Systems Hosting and Support by: OpenJournalSystems.com