Nutrigenomics of Neuradaptogen Amino-Acid-Therapy and Neurometabolic Optimizers: Overcoming carbohydrate bingeing and overeating through neurometabolic mechanisms | Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Skip to main content Skip to main navigation menu Skip to site footer Open Menu Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Home Food Science Publisher Functional Food Center Current Archives About About the Journal Aims and Scope Contact Editing Services Editorial Team Express Peer Review Graphical Abstract Journal Insights Privacy Statement Submissions Announcements Search Search Register Login Home / Archives / Vol. 1 No. 9 (2011): September 2011 / Review Articles Nutrigenomics of Neuradaptogen Amino-Acid-Therapy and Neurometabolic Optimizers: Overcoming carbohydrate bingeing and overeating through neurometabolic mechanisms Authors Kenneth Blum Department of Psychiatry, University of Florida, College of Medicine, Mcknight Brain Institute, Gainesville, Florida Debasis Bagchi Innovative Research and Clinical Trials, Iovate Inc., Toronto Abdalla Bowirrat Clinical Neuroscience and Population Genetics, Ziv Government Medical Center B. William Downs Department of Personalized Medicine, Reward Deficiency Solutions, LLC, San Diego, California Roger L. Waite Department of Personalized Medicine, Reward Deficiency Solutions, LLC, San Diego, California John Giordano Deaprtment of Holistic Medicine, G and G Hoistic Addiction Treatment Center, North Miami Beach Siohban Morse Deaprtment of Holistic Medicine, G and G Hoistic Addiction Treatment Center, North Miami Beach Margaret Madigan Department of Personalized Medicine, Reward Deficiency Solutions, LLC, San Diego, California Jaclyn M. Downs Department of Personalized Medicine, Reward Deficiency Solutions, LLC, San Diego, California Eric R. Braverman Department of Clinical Neurology, Path Foundation NY, New York, New York Margaret Polanin Department of Neurological Surgery, Weill Cornell College of Medicine, New York, New York Debmayla Barh Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, West Bengal 721172 Frank Fornari Dominion Diagnostics Inc. North Kingstown, Rhode Island Thomas Simpatico Community Mental Health Institute, Center for Clinical & Translational Science, University of Vermont and Department of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont DOI: https://doi.org/10.31989/ffhd.v1i9.121 Abstract Despite progress that has been made in the treatment of obesity, the epidemic continues to rise worldwide. While pharmacological treatment of obesity may be effective, medications may have significant side effects and can be potentially fatal. This review will provide significant evidence to substantiate the existence of Reward Deficiency Syndrome in Obesity and the role of catecholaminergic pathways in aberrant substance seeking behavior, in particular cravings for carbohydrates. The genetic basis for generalized craving behavior will be established. Evidence to support the augmentation of precursor amino acid therapy and enkephalinase, MOA and COMT inhibition leading to enhanced levels of neurotransmitters: serotonin, enkephalins, GABA and dopamine/norepinephrine as well increasing insulin sensitivity (affecting dopamine neuronal synthesis regulation) through the use of certain neurometabolic optimizers will also be provided. This review article cites many published studies to support a conceptual paradigm shift towards the use of this proposed nutrigenomic formula. The analysis and research preceding this formulation is outlined. This formulation has a generalized anti-craving effect and can inhibit carbohydrate bingeing, inducing significant healthy fat loss and prevention of relapse. This is the first time that components of this formula have been combined, at the dosage levels indicated with the goal of promoting successful and sustainable body recomposition. We are encouraging other laboratories to further evaluate Neuroadtagen Amino-Acid Therapy (NAAT)/Nurometabolic optimizers as a putative anti-obesity complex in larger controlled blinded studies and await interpretation of must these needed studies. Keywords: NAAT, Dopamine, Genes, Polymorphisms, Obesity, Craving Behavior, Overeating, Reward Deficiency Syndome, Nutrigenomics. Downloads [Abstract] [Full Article] Published 2011-09-29 Issue Vol. 1 No. 9 (2011): September 2011 Section Review Articles License Authors retain the copyright of their articles and grant the Functional Food Center (FFC) and its journals the right of first publication under the terms of the Creative Commons Attribution 4.0 International License. This license permits unrestricted use, distribution, and reproduction in any medium, including commercial use, provided the original author(s) and source are properly credited. Authors may post and share their published work freely, provided that the original publication in this journal is acknowledged. By submitting to this journal, authors confirm that their manuscripts are original, not under consideration elsewhere, and that they hold the necessary rights to grant this license. 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