The Effects of Intravenous Vitamin C Administration on hs-CRP and Tumor Necrosis Factor-α Levels in Haemodialysis Patients | Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Skip to main content Skip to main navigation menu Skip to site footer Open Menu Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Home Food Science Publisher Functional Food Center Current Archives About About the Journal Aims and Scope Contact Editing Services Editorial Team Express Peer Review Graphical Abstract Journal Insights Privacy Statement Submissions Announcements Search Search Register Login Home / Archives / Vol. 1 No. 8 (2011): August 2011 / Research Articles The Effects of Intravenous Vitamin C Administration on hs-CRP and Tumor Necrosis Factor-α Levels in Haemodialysis Patients Authors Hamid Taiebi Khosroshahi Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz Yashar Talebi Department of Nephrology, Imam Reza Hospital, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz Siamak Ahmadzadeh Department of Nephrology, Imam Reza Hospital, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz Afshin Habibzadeh c Seyyed Ehsan Mousavi Department of Nephrology, Imam Reza Hospital, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz Mohammadreza Khalilzadeh Hemodialysis Center, Imam Reza Hospital, Tabriz DOI: https://doi.org/10.31989/ffhd.v1i8.125 Abstract Background: It has been proved that pre-inflammatory factors increase mortality and morbidity of cardio-vascular diseases especially in hemodialysis patients. There is a great evidence for the increase of pre-inflammatory factors and vitamin C deficiency in dialysis patients. Limited data, however, are available regarding the effects of vitamin C supplementation on reduction of inflammatory markers in such patients. Objectives: The aim of this study is to determine the changes of hs-CRP and Tumor Necrosis Factor-α (TNF-α) levels after administration of vitamin C in End Stage Renal Disease patients (ESRD) on Hemodialysis Methods and Materials: In this clinical trial, vitamin C was administered intravenously (IV), (500 mg two times per week) for 2 months in 41 chronic hemodialysis patients and the hs-CRP and TNF-α levels of these patients were compared with a control group with no vitamin C as treatment. Besides hs-CRP and TNF-α, detailed laboratory results were evaluated before and after the study. The statistical analysis was performed using SPSS version 16 at the end of the study. Results: The hs-CRP and TNF-α levels reduced significantly in hemodialysis patients after vitamin C supplementation (hs-CRP decreased from 7.27±3.70 to 6.60± 3.75, P< 0.001 and TNF-α decreased from 25.61±12.28 to 22.82±22.83, P= 0.006), whereas the levels of these pro-inflammatory factors increased in hemodialysis patients without vitamin C supplementation (hs-CRP increased from 7.13±3.56 to 7.73±3.83, P= 0.049 and TNF-α increased from 21.32±5.64 to 23.63±15.59, P= 0.353). Vitamin C supplementation also reduced ESR level and increased Hb level significantly but it had no influence on lipid profile. Conclusion: According to the findings of this study, it seems that vitamin C administration can reduce hs-CRP and TNF-α level in hemodialysis patients and as a result prevent atherosclerosis. It can be concluded that administration of vitamin C supplementation is beneficial in hemodialysis patients. Key words: hemodialysis, hs-CRP, TNF-α, Vitamin C Downloads [Abstract] [Full Article] Published 2011-08-30 Issue Vol. 1 No. 8 (2011): August 2011 Section Research Articles License Authors retain the copyright of their articles and grant the Functional Food Center (FFC) and its journals the right of first publication under the terms of the Creative Commons Attribution 4.0 International License. This license permits unrestricted use, distribution, and reproduction in any medium, including commercial use, provided the original author(s) and source are properly credited. Authors may post and share their published work freely, provided that the original publication in this journal is acknowledged. By submitting to this journal, authors confirm that their manuscripts are original, not under consideration elsewhere, and that they hold the necessary rights to grant this license. The Functional Food Center encourages open scientific exchange and allows derivative and extended works, provided attribution to the original publication is maintained. About the Journal      Editing Services      Graphical Abstract      Journal Insights        Submissions        Editorial Team       Privacy Statement        Contact        Current        Archives   Open Journal Systems Hosting and Support by: OpenJournalSystems.com