Improvement in autonomic balance through 12-week supplementation of a novel curcumin formulation in healthy Japanese adults: A randomized, placebo-controlled study | Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Skip to main content Skip to main navigation menu Skip to site footer Open Menu Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Home Food Science Publisher Functional Food Center Current Archives About About the Journal Aims and Scope Contact Editing Services Editorial Team Express Peer Review Graphical Abstract Journal Insights Privacy Statement Submissions Announcements Search Search Register Login Home / Archives / Vol. 14 No. 6 (2024): June 2024 / Research Articles Improvement in autonomic balance through 12-week supplementation of a novel curcumin formulation in healthy Japanese adults: A randomized, placebo-controlled study Authors Kuwabara Yoshitaka Hyunjin Lee Akiko Hirose Yuji Makino Kyohei Hashimoto Misaki Sakata Tadashi Watanabe DOI: https://doi.org/10.31989/ffhd.v14i6.1330 Abstract Background: Curcumin has several health benefits due to its potent antioxidant and anti-inflammatory properties, but its bioavailability is very low, limiting its potential. We have developed a novel curcumin formulation, TS-P1, which has an 85.2-fold higher bioavailability of curcumin than raw curcumin.   Objective: To investigate the efficacy of TS-P1 on fatigue, mood status, and autonomic function.   Methods: Ninety healthy Japanese adults were randomized to the placebo or TS-P1 group and took either the placebo or TS-P1 containing 150 mg of curcumin for 12 weeks. Visual Analogue Scale for Fatigue (VAS-F) scores, Profile of Mood States Questionnaire second edition (POMS2) scores, and autonomic functions were measured every 4 weeks.   Results: Both groups showed an improvement in the VAS-F over the study period, but there was no significant difference between the placebo and TS-P1 groups. However, the mean change from baseline in the anger and depression scores of the POMS2, particularly in those aged 40 and over, in the TS-P1 group showed a greater range of decline at week 12. The mean change from baseline in LnLF and LF/HF also decreased in the TS-P1 group. Blood pressure also decreased in the TS-P1 group.   Conclusions: These data suggest that TS-P1 induced a parasympathetic dominant state, and that curcumin has an important role in the regulation of autonomic balance. 12 weeks of supplementation of TS-P1 is expected to improve both mood status and vascular function.   Trial registration: UMIN000050377   Foundation: Theravalues Corporation   Keywords: curcumin; TS-P1: Theracurmin Super; mood status; autonomic balance, parasympathetic dominance; vascular function Downloads [Abstract] [Full Article] Published 2024-06-08 Issue Vol. 14 No. 6 (2024): June 2024 Section Research Articles License Copyright (c) 2024 Functional Foods in Health and Disease This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. Authors retain the copyright of their articles and grant the Functional Food Center (FFC) and its journals the right of first publication under the terms of the Creative Commons Attribution 4.0 International License. This license permits unrestricted use, distribution, and reproduction in any medium, including commercial use, provided the original author(s) and source are properly credited. Authors may post and share their published work freely, provided that the original publication in this journal is acknowledged. By submitting to this journal, authors confirm that their manuscripts are original, not under consideration elsewhere, and that they hold the necessary rights to grant this license. The Functional Food Center encourages open scientific exchange and allows derivative and extended works, provided attribution to the original publication is maintained. About the Journal      Editing Services      Graphical Abstract      Journal Insights        Submissions        Editorial Team       Privacy Statement        Contact        Current        Archives   Open Journal Systems Hosting and Support by: OpenJournalSystems.com