Investigating the efficacy of 18-week salmon protein hydrolysate supplementation on metabolic inflammation, well-being, and cosmetic outcomes: A pilot clinical trial in healthy adults | Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Skip to main content Skip to main navigation menu Skip to site footer Open Menu Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Home Food Science Publisher Functional Food Center Current Archives About About the Journal Aims and Scope Contact Editing Services Editorial Team Express Peer Review Graphical Abstract Journal Insights Privacy Statement Submissions Announcements Search Search Register Login Home / Archives / Vol. 14 No. 11 (2024): November 2024 / Research Articles Investigating the efficacy of 18-week salmon protein hydrolysate supplementation on metabolic inflammation, well-being, and cosmetic outcomes: A pilot clinical trial in healthy adults Authors Christian Bjerknes Nicholas Framptom Crawford Currie DOI: https://doi.org/10.31989/ffhd.v14i11.1491 Abstract Background: Fatigue is a common and debilitating symptom associated with aging, which significantly reduces quality of life. Salmon protein hydrolysate (SPH) has recently been investigated for its potential benefits in improving energy levels, reducing oxidative stress, and promoting cosmetic health. Objective: The primary objective of this proof-of-concept clinical trial was to evaluate the effects of daily low-dose SPH supplementation on energy levels, oxidative stress, inflammation, and cosmetic outcomes in healthy adults, with a focus on potential gender-specific effects. Methods: This open-label, single-arm study involved 20 participants, of which 70.6% were female. Participants consumed 4g of SPH daily for 128 days. Key outcomes measured included changes in perceived energy levels, antioxidant gene expression (HMOX1 and FTH1), free radical activity, serum cytokine levels (IL-5, IL-8, CRP, IL-2, IL-10), hematological parameters, and self-reported cosmetic outcomes. Assessments were made throughout the study to track changes over time. Results: SPH supplementation led to a significant 10.24% improvement in perceived energy levels (P = 0.004), with a greater improvement observed among women (14.55%, P = 0.008). A 9% reduction in oxidative stress (P < 0.001) was accompanied by up regulation of HMOX1 and FTH1 genes by 4.09-fold and 3.77-fold, respectively. Pro-inflammatory  markers IL-5, IL-8, and CRP decreased significantly (P < 0.001), while anti-inflammatory markers IL-2 and IL-10 increased (P < 0.001). Self-reported cosmetic outcomes improved by 23.7% (P = 0.03), with women reporting a 34.5% enhancement in hair, skin, and nail health (P = 0.009). Conclusion: Daily supplementation with low-dose SPH improved energy levels, reduced oxidative stress, and modulated inflammatory markers in healthy adults. Notably, women experienced greater improvements in both energy levels and cosmetic outcomes, suggesting SPH may be a beneficial supplement for enhancing overall well-being and cosmetic health, particularly among women. Keywords: Salmon protein hydrolysate, oxidative stress, inflammation, fatigue, cosmetic outcomes, aging. Downloads [Abstract] [Full Article] Published 2024-11-21 Issue Vol. 14 No. 11 (2024): November 2024 Section Research Articles License Copyright (c) 2024 Functional Foods in Health and Disease This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. Authors retain the copyright of their articles and grant the Functional Food Center (FFC) and its journals the right of first publication under the terms of the Creative Commons Attribution 4.0 International License. This license permits unrestricted use, distribution, and reproduction in any medium, including commercial use, provided the original author(s) and source are properly credited. Authors may post and share their published work freely, provided that the original publication in this journal is acknowledged. By submitting to this journal, authors confirm that their manuscripts are original, not under consideration elsewhere, and that they hold the necessary rights to grant this license. The Functional Food Center encourages open scientific exchange and allows derivative and extended works, provided attribution to the original publication is maintained. About the Journal      Editing Services      Graphical Abstract      Journal Insights        Submissions        Editorial Team       Privacy Statement        Contact        Current        Archives   Open Journal Systems Hosting and Support by: OpenJournalSystems.com