Passiflora ligularis extract improved acetylcholinesterase activity, oxidative stress markers, and neurocognitive outcomes in scopolamine-induced Alzheimer's model in zebrafish | Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Skip to main content Skip to main navigation menu Skip to site footer Open Menu Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Home Food Science Publisher Functional Food Center Current Archives About About the Journal Aims and Scope Contact Editing Services Editorial Team Express Peer Review Graphical Abstract Journal Insights Privacy Statement Submissions Announcements Search Search Register Login Home / Archives / Vol. 15 No. 7 (2025): July 2025 / Research Articles Passiflora ligularis extract improved acetylcholinesterase activity, oxidative stress markers, and neurocognitive outcomes in scopolamine-induced Alzheimer's model in zebrafish Authors Rosa Martha Perez Gutierrez Julio Tellez Gómez Diana Maylet Hernández Martínez Alethia Muñiz Ramirez José María Mota Flores DOI: https://doi.org/10.31989/ffhd.v15i7.1668 Abstract Background: Passiflora ligularis (granadilla) is known for its health benefits, including its potential in managing obesity.  inflammation, and diabetes. This study aimed to evaluate the effects of an   extract from P. ligularis fruit (PAS) o neuroinflammation, n cognitive function, and oxidative stress in a zebrafish model of scopolamine (SCO)-induced neurodegeneration.  Methods: Flavonoid profile was evaluated using high-performance liquid chromatography (HPLC-UV-MS). Zebrafish (Danio rerio) received oral PAS at dose of 4, 6, and 8 µg/ml or donepezil used as positive control (0.65 mg/kg) for 19 days, followed by SCO administration (100 µg/ml) one hour before behavioral tests. These included the novel tank diving test (NTT), Y-maze test, and novel object recognition test (NOR). Post-experiment biochemical brain parameters were analyzed. Results: HPLC-UV-MS identified 11 phenolic compounds previously reported for their neuroprotective potential. PAS treatment significantly improved acetylcholinesterase (AChE) activity, oxidative stress markers, and neurocognitive impairments, demonstrating effects comparable to the donepezil group.  Conclusions: These findings suggest that Passiflora ligularis extract may be a promising phytotherapeutic approach for alleviating memory impairment and symptoms associated with Alzheimer’s disease. Novelty of the study: This study investigates the effect of Passiflora ligularis extract on neurodegenerative disease in zebrafish model, revealing its potential to alleviate neurocognitive impairments mitigate neuroinflammation, reactive oxygen species and acetylcholinesterase. Keyword: Passiflora ligularis; Alzheimer´s disease; neurodegenerative disease; oxidative stress   Downloads [Abstract] [Full Article] Published 2025-07-25 Issue Vol. 15 No. 7 (2025): July 2025 Section Research Articles License Copyright (c) 2025 Functional Foods in Health and Disease This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. Authors retain the copyright of their articles and grant the Functional Food Center (FFC) and its journals the right of first publication under the terms of the Creative Commons Attribution 4.0 International License. This license permits unrestricted use, distribution, and reproduction in any medium, including commercial use, provided the original author(s) and source are properly credited. Authors may post and share their published work freely, provided that the original publication in this journal is acknowledged. By submitting to this journal, authors confirm that their manuscripts are original, not under consideration elsewhere, and that they hold the necessary rights to grant this license. The Functional Food Center encourages open scientific exchange and allows derivative and extended works, provided attribution to the original publication is maintained. About the Journal      Editing Services      Graphical Abstract      Journal Insights        Submissions        Editorial Team       Privacy Statement        Contact        Current        Archives   Open Journal Systems Hosting and Support by: OpenJournalSystems.com