The influence of 2'-fucosyllactose on intestinal cell function: A comprehensive review of experimental studies | Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Skip to main content Skip to main navigation menu Skip to site footer Open Menu Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Home Food Science Publisher Functional Food Center Current Archives About About the Journal Aims and Scope Contact Editing Services Editorial Team Express Peer Review Graphical Abstract Journal Insights Privacy Statement Submissions Announcements Search Search Register Login Home / Archives / Vol. 15 No. 10 (2025): October 2025 / Review Articles The influence of 2'-fucosyllactose on intestinal cell function: A comprehensive review of experimental studies Authors Eko Sulistijono Loeki Enggar Fitri Krisni Subandiyah Husnul Khotimah DOI: https://doi.org/10.31989/ffhd.v15i10.1675 Abstract Necrotizing enterocolitis (NEC) is one of the most common gastrointestinal illnesses that causes preterm neonates to die. This occurs because Toll-like receptor 4 (TLR4) is activated by lipopolysaccharides, and preterm newborns' intestines express TLR4 at far greater levels than those of full-term neonates. NEC occurs in approximately 1 out of every 1,000 live births, with 5% to 10% incidence, and over 90% of cases are observed in infants younger than one month. Certain elements in breast milk have been found to help lower the risk of NEC. This systematic review aims to analyze various experimental studies related to the administration of 2’-Fucosyllactose (2'FL) that have the potential to induce improvement and therapy in NEC cases through intestinal cell function. There have not been many systematic reviews that specifically highlight the therapeutic effects of 2'FL on Necrotizing Enterocolitis (NEC), most of which still address the role of human milk oligosaccharides (HMOs). The results show that the search flow uses the PRISMA Flowchart; after screening 133 titles and abstracts, 55 studies were accessed to verify the feasibility of the full text. Overall, there were 5 studies selected in this study for a comprehensive review. According to the study's findings, 2'-FL, one of the HMOs, has a number of advantageous impacts on the host's immune system and digestive tract. Among many other advantages, HMOs have been shown to boost the immunological response to vaccinations, influence the makeup of the gut microbiota, and enhance the expression of genes related to gut function. Keywords: NEC, HMOs, 2'-FL, Intestine, TLR4. Downloads [Abstract] [Full Article] Published 2025-10-06 Issue Vol. 15 No. 10 (2025): October 2025 Section Review Articles License Copyright (c) 2025 Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. Authors retain the copyright of their articles and grant the Functional Food Center (FFC) and its journals the right of first publication under the terms of the Creative Commons Attribution 4.0 International License. This license permits unrestricted use, distribution, and reproduction in any medium, including commercial use, provided the original author(s) and source are properly credited. Authors may post and share their published work freely, provided that the original publication in this journal is acknowledged. By submitting to this journal, authors confirm that their manuscripts are original, not under consideration elsewhere, and that they hold the necessary rights to grant this license. The Functional Food Center encourages open scientific exchange and allows derivative and extended works, provided attribution to the original publication is maintained. About the Journal      Editing Services      Graphical Abstract      Journal Insights        Submissions        Editorial Team       Privacy Statement        Contact        Current        Archives   Open Journal Systems Hosting and Support by: OpenJournalSystems.com