Water-soluble low-molecular-weight b-(1, 3–1, 6) D-Glucan inhibit cedar pollinosis | Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Skip to main content Skip to main navigation menu Skip to site footer Open Menu Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Home Food Science Publisher Functional Food Center Current Archives About About the Journal Aims and Scope Contact Editing Services Editorial Team Express Peer Review Graphical Abstract Journal Insights Privacy Statement Submissions Announcements Search Search Register Login Home / Archives / Vol. 5 No. 2 (2015): February 2015 / Short Report Water-soluble low-molecular-weight b-(1, 3–1, 6) D-Glucan inhibit cedar pollinosis Authors Tomoko Jippo Department of Food and Nutrition, Faculty of Human Life Sciences, Senri Kinran University, 5-25-1 Fujishirodai, Suita, Osaka 565-0873, Japan; Toshio Suzuki Department of Applied Chemistry and Bioengineering, Graduate School of Engineering, Osaka City University, Sugimoto 3-3-138, Sumiyoshi-ku, Osaka 558-8585, Japan Harumi Sato Department of Food and Nutrition, Faculty of Human Life Sciences, Senri Kinran University, 5-25-1 Fujishirodai, Suita, Osaka 565-0873, Japan; Yuko Kobayashi Department of Food and Nutrition, Faculty of Human Life Sciences, Senri Kinran University, 5-25-1 Fujishirodai, Suita, Osaka 565-0873, Japan; Munekazu Shigekawa Department of Food and Nutrition, Faculty of Human Life Sciences, Senri Kinran University, 5-25-1 Fujishirodai, Suita, Osaka 565-0873, Japan; DOI: https://doi.org/10.31989/ffhd.v5i2.173 Abstract Background: The incidences of allergenic diseases such as allergenic rhinitis, atopic dermatitis, asthma, and food allergies have increased in several countries. Mast cells have critical roles in various biological processes related to allergenic diseases. Mast cells express the high-affinity receptor for immunoglobulin (Ig) E on their surface. The interaction of multivalent antigens with surface-bound IgE causes the secretion of granule-stored mediators, as well as the de novo synthesis of cytokines. Those mediators and cytokines proceed the allergenic diseases. We investigated the effects of water-soluble, low-molecular-weight b-(1, 3–1, 6) D-glucan isolated from Aureobasidium pullulans 1A1 strain black yeast (LMW-b-glucan) on mast cell-mediated anaphylactic reactions. We reported that LMW-b-glucan dose-dependently inhibited the degranulation of mast cells. Furthermore, we found that orally administered LMW-b-glucan inhibited the IgE-mediated passive cutaneous anaphylaxis (PCA) reaction in mice. Here, we examined if LMW-b-glucan had any effects on Japanese cedar pollinosis. Findings: In a clinical study, a randomized, single-blind, placebo-controlled, parallel group study in 65 subjects (aged 22-62) was performed. This study was undertaken 3 weeks before the cedar pollen season and until the end of the cedar pollen season. During the study, all subjects consumed one bottle of placebo or LMW-b-glucan daily, and all subjects were required to record allergenic symptoms in a diary. The LMW-b-glucan group had a significantly lower prevalence of sneezing, nose-blowing, tears, and hindrance to the activities of daily living than the placebo group. Conclusions: These results suggest that LMW-b-glucan could be an effective treatment for allergenic diseases. Key Words: Mast cell, anti-allergy, b-glucan, cedar pollinosis Downloads [Abstract] [Full Article] Published 2015-02-25 Issue Vol. 5 No. 2 (2015): February 2015 Section Short Report License Authors retain the copyright of their articles and grant the Functional Food Center (FFC) and its journals the right of first publication under the terms of the Creative Commons Attribution 4.0 International License. This license permits unrestricted use, distribution, and reproduction in any medium, including commercial use, provided the original author(s) and source are properly credited. Authors may post and share their published work freely, provided that the original publication in this journal is acknowledged. By submitting to this journal, authors confirm that their manuscripts are original, not under consideration elsewhere, and that they hold the necessary rights to grant this license. The Functional Food Center encourages open scientific exchange and allows derivative and extended works, provided attribution to the original publication is maintained. About the Journal      Editing Services      Graphical Abstract      Journal Insights        Submissions        Editorial Team       Privacy Statement        Contact        Current        Archives   Open Journal Systems Hosting and Support by: OpenJournalSystems.com