In vivo anti-carcinogenic property of a formulated citrus peel extract | Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Skip to main content Skip to main navigation menu Skip to site footer Open Menu Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Home Food Science Publisher Functional Food Center Current Archives About About the Journal Aims and Scope Contact Editing Services Editorial Team Express Peer Review Graphical Abstract Journal Insights Privacy Statement Submissions Announcements Search Search Register Login Home / Archives / Vol. 4 No. 3 (2014): March 2014 / Research Articles In vivo anti-carcinogenic property of a formulated citrus peel extract Authors Michiko Suzawa Miyauchi Citrus Research Center, Ltd., 324-10 Shigoka-Machi, Takasaki, Gunma 370-0845 Limin Guo Xinjiang Academy of Agricultural Sciences, Urumqi, Xinjiang 830091 Min-Hsiung Pan Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung 811 Chi-Tang Ho Department of Food Science, Rutgers University, New Brunswick, NJ 08901 Shiming Li Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, Huanggang Normal University, Huanggang, Hubei DOI: https://doi.org/10.31989/ffhd.v4i3.21 Abstract Background: Cancer is one of the two leading fatal diseases humans face. Synthesized drugs available for cancer intervention have many limitations in applications and effectiveness and are often associated with serious of side effects, which can further damage the patients’ quality of life.  Recently, the development of natural-product-based and therapeutically sound anti-cancer agents have gained popularity in the fields of functional and medical foods, which may exhibit advantages of minimal toxicity and multiple active molecular components. Citrus peel or its extract has been reported to have potent pharmacological activities and health benefits because of abundant flavonoids present in citrus fruits, particularly in the peels.  Results: The results of these studies demonstrated the efficacy of Gold Lotion (GL), an extract of multiple varieties of citrus peels that contains abundant flavonoids, including a high percentage of polymethoxylflavones (PMFs), which can protect against skin cancer, colon cancer, and prostate cancer in mice.  These results are clearly promising and warrant a human trial with GL in future studies.  Summary: Briefly, these data have demonstrated that GL is efficacious in preventing and treating cancer in several model systems. This review summarizes the results of currently available data regarding the in vivo anti-cancer activity of GL, and identifies opportunities for subsequent human clinical trials to assess preventive and therapeutic effects in the near future. Keywords: gold lotion, citrus peel extracts, skin cancer, colon cancer, prostate cancer  Downloads [Abstract] [Full Article] Published 2014-03-31 Issue Vol. 4 No. 3 (2014): March 2014 Section Research Articles License Authors retain the copyright of their articles and grant the Functional Food Center (FFC) and its journals the right of first publication under the terms of the Creative Commons Attribution 4.0 International License. This license permits unrestricted use, distribution, and reproduction in any medium, including commercial use, provided the original author(s) and source are properly credited. Authors may post and share their published work freely, provided that the original publication in this journal is acknowledged. By submitting to this journal, authors confirm that their manuscripts are original, not under consideration elsewhere, and that they hold the necessary rights to grant this license. The Functional Food Center encourages open scientific exchange and allows derivative and extended works, provided attribution to the original publication is maintained. About the Journal      Editing Services      Graphical Abstract      Journal Insights        Submissions        Editorial Team       Privacy Statement        Contact        Current        Archives   Open Journal Systems Hosting and Support by: OpenJournalSystems.com