A randomized, controlled trial to assess short-term black pepper consumption on 24-hour energy expenditure and substrate utilization | Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Skip to main content Skip to main navigation menu Skip to site footer Open Menu Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Home Food Science Publisher Functional Food Center Current Archives About About the Journal Aims and Scope Contact Editing Services Editorial Team Express Peer Review Graphical Abstract Journal Insights Privacy Statement Submissions Announcements Search Search Register Login Home / Archives / Vol. 3 No. 10 (2013): October 2013 / Research Articles A randomized, controlled trial to assess short-term black pepper consumption on 24-hour energy expenditure and substrate utilization Authors Annalouise O’Connor UNC Nutrition Research Institute, University of North Carolina Chapel Hill, North Carolina Research Campus, Kannapolis, North Carolina Karen D. Corbin UNC Nutrition Research Institute, University of North Carolina Chapel Hill, North Carolina Research Campus, Kannapolis, North Carolina David C. Nieman Human Performance Laboratory, Appalachian State University, North Carolina Research Campus, Kannapolis North Carolina Andrew G. Swick UNC Nutrition Research Institute, University of North Carolina Chapel Hill, North Carolina Research Campus, Kannapolis, North Carolina DOI: https://doi.org/10.31989/ffhd.v3i10.38 Abstract Background: Thermogenic ingredients may play a role in weight management. In vitro and rodent work suggests that components of black pepper may impact energy expenditure, and in humans, other TPRV1 agonists e.g. capsaicin, augment EE. Objectives: To determine the impact of BP on 24-hour EE, respiratory quotient, and biochemical markers of metabolism and satiety, a randomized, controlled, cross-over study of black pepper (0.5mg/meal) versus no pepper control was conducted in post-menopausal women. Subjects spent two 24-hour periods in a whole room indirect calorimeter. Results: Post-meal glucose, insulin, gut peptides and catecholamines were measured. Energy expenditure, respiratory quotient, or biochemical markers assessed did not differ significantly between the black pepper and no pepper control study days. Conclusions: Our findings do not support a role for black pepper in modulating energy expenditure in overweight postmenopausal women. Future work targeting alternative populations, administering black pepper in the fasted state, or in combination with other spices, may reveal the thermogenic effect of this spice. Trial registration: This trial was registered at clinicaltrials.gov (NCT01729143). Key words: Black pepper, piperine, energy expenditure, metabolic chamber Downloads [Abstract] [Full Article] Published 2013-10-15 Issue Vol. 3 No. 10 (2013): October 2013 Section Research Articles License Authors retain the copyright of their articles and grant the Functional Food Center (FFC) and its journals the right of first publication under the terms of the Creative Commons Attribution 4.0 International License. This license permits unrestricted use, distribution, and reproduction in any medium, including commercial use, provided the original author(s) and source are properly credited. Authors may post and share their published work freely, provided that the original publication in this journal is acknowledged. By submitting to this journal, authors confirm that their manuscripts are original, not under consideration elsewhere, and that they hold the necessary rights to grant this license. The Functional Food Center encourages open scientific exchange and allows derivative and extended works, provided attribution to the original publication is maintained. About the Journal      Editing Services      Graphical Abstract      Journal Insights        Submissions        Editorial Team       Privacy Statement        Contact        Current        Archives   Open Journal Systems Hosting and Support by: OpenJournalSystems.com