Effects of Oral Supplementation with Pyrroloquinoline Quinone on Stress, Fatigue, and Sleep | Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Skip to main content Skip to main navigation menu Skip to site footer Open Menu Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Home Food Science Publisher Functional Food Center Current Archives About About the Journal Aims and Scope Contact Editing Services Editorial Team Express Peer Review Graphical Abstract Journal Insights Privacy Statement Submissions Announcements Search Search Register Login Home / Archives / Vol. 2 No. 8 (2012): August 2012 / Research Articles Effects of Oral Supplementation with Pyrroloquinoline Quinone on Stress, Fatigue, and Sleep Authors Masahiko Nakano 1Niigata Research Laboratory, Mitsubishi Gas Chemical Company, Inc., 182 Shinwari, Tayuhama, Kita-ku, Niigata 950-3112 Tetsuro Yamamoto TTC Co., Ltd., 1-20-2 Ebisunishi, Shibuya-ku, Tokyo 150-0021 Hisayoshi Okamura Cognitive and Molecular Institute of Brain Diseases, Kurume University, 67 Asahi-machi, Kurume, Fukuoka 830-0011 Akira Tsuda 4Department of Psychology, Kurume University, 1635 Miimachi, Kurume 839-8502 Yasuyuki Kowatari Ueno Clinic, Aisei Hospital, 2-18-6 Higashiueno, Taito-ku, Tokyo, 110-0015 DOI: https://doi.org/10.31989/ffhd.v2i8.81 Abstract Seventeen adult male and female subjects participated in a clinical trial using an open-label trial to evaluate the effectiveness of pyrroloquinoline quinone (PQQ) on stress, fatigue, quality of life and sleep. They ingested 20 mg of PQQ daily for 8 weeks. Changes in stress, fatigue, quality of life measures and sleep were evaluated using various inventories and questionnaires. For example, the results of the Profile of Mood States-Short Form revealed that all six measures of vigor, fatigue, tension-anxiety, depression, anger-hostility and confusion were significantly improved following PQQ administration compared with scores for those measures before administration of PQQ. Measures for quality of life, appetite, sleep, obsession and pain, also improved significantly. The results of the Oguri-Shirakawa-Azumi Sleep Inventory (Middle Aged and Aged version) showed significant improvement in sleepiness at awakening, sleep onset and maintenance, and sleep duration. For validation, the Pittsburgh Sleep Quality Index Japanese version also showed significant improvement in sleep-related behavior. Furthermore, the changes in these global scores were correlated with changes in the cortisol awakening response (R = -0.55), i.e. the effects of PQQ on improvement of sleep quality are supported by a biomarker. Keywords: Pyrroloquinoline quinone, stress, fatigue, quality of life, sleep Downloads [Abstract] [Full Article] Published 2012-08-31 Issue Vol. 2 No. 8 (2012): August 2012 Section Research Articles License Authors retain the copyright of their articles and grant the Functional Food Center (FFC) and its journals the right of first publication under the terms of the Creative Commons Attribution 4.0 International License. This license permits unrestricted use, distribution, and reproduction in any medium, including commercial use, provided the original author(s) and source are properly credited. Authors may post and share their published work freely, provided that the original publication in this journal is acknowledged. By submitting to this journal, authors confirm that their manuscripts are original, not under consideration elsewhere, and that they hold the necessary rights to grant this license. The Functional Food Center encourages open scientific exchange and allows derivative and extended works, provided attribution to the original publication is maintained. About the Journal      Editing Services      Graphical Abstract      Journal Insights        Submissions        Editorial Team       Privacy Statement        Contact        Current        Archives   Open Journal Systems Hosting and Support by: OpenJournalSystems.com