Effects of the consumption of proanthocyanidins derived from acacia bark on blood pressure in healthy Japanese adults: A randomized, double-blind, placebo-controlled, parallel-group comparison study | Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Skip to main content Skip to main navigation menu Skip to site footer Open Menu Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Home Food Science Publisher Functional Food Center Current Archives About About the Journal Aims and Scope Contact Editing Services Editorial Team Express Peer Review Graphical Abstract Journal Insights Privacy Statement Submissions Announcements Search Search Register Login Home / Archives / Vol. 11 No. 7 (2021): July 2021 / Research Articles Effects of the consumption of proanthocyanidins derived from acacia bark on blood pressure in healthy Japanese adults: A randomized, double-blind, placebo-controlled, parallel-group comparison study Authors Asami Baba ORTHOMEDICO Inc. Tomohiro Hoshino ORTHOMEDICO Inc. Sosuke Ogawa Acacia-No-Ki Co.,Ltd. Tsuyoshi Takara Medical Corporation Seishinkai, Takara Clinic DOI: https://doi.org/10.31989/ffhd.v11i7.814 Abstract Objective: The aim of this study is to verify the effects of consuming proanthocyanidins derived from acacia bark on improving blood pressure and blood circulation in healthy Japanese adult subjects.   Methods: This was a randomized, double-blind, placebo-controlled, parallel-comparison study involving 66 healthy Japanese adults. Subjects were allocated into either acacia or placebo group (n = 33 each) using a random number generator. Subjects consumed six tablets/day of either acacia bark extract tablets or placebo for 12 weeks. The primary outcome was the measured value of sitting systolic blood pressure at 12 weeks, whereas the secondary outcomes were sitting systolic and diastolic blood pressures, superoxide dismutase activity in blood, and blood flow. Results: The number of subjects analyzed as full analysis set was 33 (20 men and 13 women) in the Acacia group and 31 (23 men and 8 women) in the placebo group. Compared with the placebo group, the measured values and changes from baseline at 4, 8, and 12 weeks of the sitting systolic blood pressure were significantly lower in the Acacia group. Furthermore, “the ratio of the number of subjects whose sitting systolic blood pressure <130 mmHg and diastolic blood pressure ≤89 mmHg at 12 weeks” of the Acacia group was significantly higher than that of the placebo group. No adverse event was observed.   Conclusions: Proanthocyanidins derived from acacia bark showed a hypotensive effect.   Trial registration: UMIN-CTR: UMIN000039416.   Foundation: Acacia-No-Ki Co., Ltd.   Keywords: Acacia bark extract, Proanthocyanidins, Systolic blood pressure, Diastolic blood pressure Downloads [Abstract] [Full Article] [Appendix] Published 2021-07-16 Issue Vol. 11 No. 7 (2021): July 2021 Section Research Articles License Authors retain the copyright of their articles and grant the Functional Food Center (FFC) and its journals the right of first publication under the terms of the Creative Commons Attribution 4.0 International License. This license permits unrestricted use, distribution, and reproduction in any medium, including commercial use, provided the original author(s) and source are properly credited. Authors may post and share their published work freely, provided that the original publication in this journal is acknowledged. By submitting to this journal, authors confirm that their manuscripts are original, not under consideration elsewhere, and that they hold the necessary rights to grant this license. The Functional Food Center encourages open scientific exchange and allows derivative and extended works, provided attribution to the original publication is maintained. About the Journal      Editing Services      Graphical Abstract      Journal Insights        Submissions        Editorial Team       Privacy Statement        Contact        Current        Archives   Open Journal Systems Hosting and Support by: OpenJournalSystems.com