Effect of calafate (Berberis microphylla) supplementation on lipid profile in rats with diet-induced obesity | Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Skip to main content Skip to main navigation menu Skip to site footer Open Menu Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Home Food Science Publisher Functional Food Center Current Archives About About the Journal Aims and Scope Contact Editing Services Editorial Team Express Peer Review Graphical Abstract Journal Insights Privacy Statement Submissions Announcements Search Search Register Login Home / Archives / Vol. 11 No. 10 (2021): October 2021 / Research Articles Effect of calafate (Berberis microphylla) supplementation on lipid profile in rats with diet-induced obesity Authors Carla Guzmán University San Sebastian Raúl Sánchez University of La Frontera DOI: https://doi.org/10.31989/ffhd.v11i10.823 Abstract Background: Polyphenols represent a group of bioactive compounds of interest for their efficacy in the prevention and treatment of some diseases of a cardiovascular nature. Calafate (Berberis microphylla) is a native Chilean fruit, promising due to its high number of phenolic compounds, with predominance of anthocyanins delphinidin-3-hexoside and petunidin-3-hexoside.    Methods: Sprague Dawley rats fed a high-fat diet (HFD) were supplemented with 350 mg/kg of freeze-dried calafate for 10 weeks. Dietary variables, plasma glucose, lipid profile, as well as atherogenic and cardiovascular risk indexes were measured.    Results: Animals receiving calafate with their HFD diet compared to the HFD control was not associated with significant modifications in dietary variables or in total cholesterol and triglyceride concentrations. However, due to the modest elevation of high-density lipoproteins, the Atherogenic Index and the Cardiovascular Risk Index were significantly decreased.    Conclusion: Based on these results, the calafate could have an antithrombotic function, favoring cardiovascular health.   Keywords: High-fat diet, polyphenols, calafate berry, HDL-cholesterol, Atherogenic Index Author Biographies Carla Guzmán, University San Sebastian Faculty of Health Care Sciencies. University San Sebastian Academic Nutrition and Dietetics Career     Raúl Sánchez, University of La Frontera Faculty of Medicine. University of La Frontera. Academic Program in Medical Sciencies. Downloads [Abstract] [Full Article] Published 2021-10-05 Issue Vol. 11 No. 10 (2021): October 2021 Section Research Articles License Authors retain the copyright of their articles and grant the Functional Food Center (FFC) and its journals the right of first publication under the terms of the Creative Commons Attribution 4.0 International License. This license permits unrestricted use, distribution, and reproduction in any medium, including commercial use, provided the original author(s) and source are properly credited. Authors may post and share their published work freely, provided that the original publication in this journal is acknowledged. By submitting to this journal, authors confirm that their manuscripts are original, not under consideration elsewhere, and that they hold the necessary rights to grant this license. The Functional Food Center encourages open scientific exchange and allows derivative and extended works, provided attribution to the original publication is maintained. About the Journal      Editing Services      Graphical Abstract      Journal Insights        Submissions        Editorial Team       Privacy Statement        Contact        Current        Archives   Open Journal Systems Hosting and Support by: OpenJournalSystems.com