Correction of metabolic disturbances by functional food compositions in experimental obesity in CD-1 and agouti-yellow mice | Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Skip to main content Skip to main navigation menu Skip to site footer Open Menu Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Home Food Science Publisher Functional Food Center Current Archives About About the Journal Aims and Scope Contact Editing Services Editorial Team Express Peer Review Graphical Abstract Journal Insights Privacy Statement Submissions Announcements Search Search Register Login Home / Archives / Vol. 12 No. 1 (2022): January 2022 / Research Articles Correction of metabolic disturbances by functional food compositions in experimental obesity in CD-1 and agouti-yellow mice Authors Petr Lebedev Anna Peresypkina Belgorod State National Research University https://orcid.org/0000-0003-2829-9860 Vasiliy Gustinovich Oleg Godunov Vladimir Gustinovich Maria Zatolokina Artem Goliusov Mikhail Pokrovskii DOI: https://doi.org/10.31989/ffhd.v12i1.874 Abstract Background: To determine the most promising composition, the possibility of correction of metabolic disturbances was investigated with the use of functional food compositions in CD1 and agouti-yellow mice in experimental obesity. Methods: Agouti-yellow and CD1 mice were divided into 10 groups (control, 1/1, 1/9, 2/1, 2/9 in each line) according to diets. For 4 weeks, the groups ate a high-calorie diet. Starting with week 5th, composition 1 was added to the diet in groups 1/1 (60% lard + 39% standard laboratory feed + 1% composition 1 + 10% fructose solution), 1/9 (60% lard + 31% standard laboratory feed + 9% composition 1 + 10% fructose solution); composition 2 was added to the diet in groups 2/1 (60% lard + 39% standard laboratory feed + 1% composition 2 + 10% fructose solution), 2/9 (60% lard + 39% standard laboratory feed + 9% composition 2 + 10% fructose solution). On the day 56th, each animal was weighed, blood was taken for biochemical analysis (glucose, LDL, cholesterol and HDL) and organs (the skin of the anterior abdominal wall, skeletal muscle tissue in the area of the lateral surface of the thigh, liver, kidneys with perirenal tissue, pancreas, and thymus) were taken for histological examination. Results: In agouti-yellow mice, group 2/9, the greatest decrease in blood glucose level was observed compared to the control group by 34.6% (p < 0.05). Consumption of compositions in groups 1/9 and 2/9 led to a significant decrease in LDL and a significant decrease in total cholesterol level by 21.9% (p < 0.05) and 18.8% (p < 0.05) respectively compared to the control group. HDL was significantly higher in groups 1/9, 2/9 than in the control group. In CD-1 mice, group 2/9 showed the best result in glucose level (mean 5.78 mmol/l) among all groups receiving functional food compositions and the control group. The most pronounced decrease in LDL was observed in groups 1/9, 2/9 compared to the control group (p < 0.05). HDL value in group 2/9 significantly exceeded the mean value in the control group, by 54.8% (p < 0.05). Body mass of agouti-yellow mice and CD-1 mice in groups 1/1, 2/1, 1/9, and 2/9 significantly decreased compared to control groups. According to the results of histological examination of organs and tissues, functional food composition 2 turned out to be the most promising. Conclusion: According to the results of the study, the most promising composition was selected (composition 2). Feeding animals with this composition improved histological pictures of studied organs and tissues, biochemical blood parameters and effectively reduced body mass in both experimental animal lines, CD-1, and agouti-yellow mice, compared to the control groups.   Keywords: CD-1 mice, agouti-yellow mice, experimental obesity, LDL, cholesterol Author Biography Anna Peresypkina, Belgorod State National Research University Профессор кафедры фармакологии и клинической фармакологии Института медицины Белгородского государственного национального исследовательского университета Downloads [Abstract] [Full Article] Published 2022-01-17 Issue Vol. 12 No. 1 (2022): January 2022 Section Research Articles License Authors retain the copyright of their articles and grant the Functional Food Center (FFC) and its journals the right of first publication under the terms of the Creative Commons Attribution 4.0 International License. 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