Nutritional and anti-gastro ulcerative role of the gum Arabic (Acacia senegal L.) compared to a reference drug | Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Skip to main content Skip to main navigation menu Skip to site footer Open Menu Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Home Food Science Publisher Functional Food Center Current Archives About About the Journal Aims and Scope Contact Editing Services Editorial Team Express Peer Review Graphical Abstract Journal Insights Privacy Statement Submissions Announcements Search Search Register Login Home / Archives / Vol. 12 No. 6 (2022): June 2022 / Research Articles Nutritional and anti-gastro ulcerative role of the gum Arabic (Acacia senegal L.) compared to a reference drug Authors Qaswaa Yousif Jameel Department of Food Science, Colleges of Agricultural and Forestry, University of Mosul, Mosul, Iraq Mohammed Abdullah Ajeel Colleges of Pharmacy, University of Mosul, Mosul, Iraq Nameer Khairullah Mohammed Department of Food Science, College of Agriculture, Tikrit University 3400, Tikrit, Iraq DOI: https://doi.org/10.31989/ffhd.v12i6.929 Abstract Background: As alcohol consumption increases, ethanol impacts ulcers as a factor that causes stomach mucosal invasion, which leads to stomach ulcers. Alcohol damages the stomach through a number of processes, including increased gastric secretion, the release of pro-inflammatory cytokines, and ethanol induces a variety of pathogenic events as it is associated with the formation of stomach ulcers. Objective: The goal of this study was to see if gum Arabic as a functional food could protect albino rats against ethanol-induced stomach damage. Materials and Methods: Six groups of 30 female albino rats were formed: normal control, ulcer control, omeprazole + ethanol, and groups 4, 5, and 6, which were given GA at 7.5, 12, 25 g/ kg/ day (bw), then lab rat were given 5 mL/kg /day (bw) ethanol orally for 30 days to cause stomach mucosal damage. Results: GA suppressed gastric inflammation by lowering TNF-α and IL-6 levels while increasing IL-10 levels. GA also improved HDL, total protein, albumin, and globulin levels while lowering cholesterol, triglycerides, VLDL-C, LDL-C, and phospholipids. Conclusion: These findings demonstrate that GA plays a protective role toward gastric mucosal injury in rats induced by ethanol, which in turn reduced the inflammatory response, and significantly reduced the hemorrhagic gastric lesions and the pH of the gastric contents.   Keywords: Functional food, Alcoholic, polysaccharides, soluble fiber, tumor necrosis factor alpha, oxidative stress   Downloads [Abstract] [Full Article] Published 2022-06-23 Issue Vol. 12 No. 6 (2022): June 2022 Section Research Articles License Authors retain the copyright of their articles and grant the Functional Food Center (FFC) and its journals the right of first publication under the terms of the Creative Commons Attribution 4.0 International License. This license permits unrestricted use, distribution, and reproduction in any medium, including commercial use, provided the original author(s) and source are properly credited. Authors may post and share their published work freely, provided that the original publication in this journal is acknowledged. By submitting to this journal, authors confirm that their manuscripts are original, not under consideration elsewhere, and that they hold the necessary rights to grant this license. The Functional Food Center encourages open scientific exchange and allows derivative and extended works, provided attribution to the original publication is maintained. About the Journal      Editing Services      Graphical Abstract      Journal Insights        Submissions        Editorial Team       Privacy Statement        Contact        Current        Archives   Open Journal Systems Hosting and Support by: OpenJournalSystems.com