Beneficial effects of gymnemic acid on three-dimensional vascular architecture and expression of vascular endothelial growth factor of intrarenal segmental and interlobar arteries in diabetic rat kidney | Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Skip to main content Skip to main navigation menu Skip to site footer Open Menu Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007 Home Food Science Publisher Functional Food Center Current Archives About About the Journal Aims and Scope Contact Editing Services Editorial Team Express Peer Review Graphical Abstract Journal Insights Privacy Statement Submissions Announcements Search Search Register Login Home / Archives / Vol. 12 No. 6 (2022): June 2022 / Research Articles Beneficial effects of gymnemic acid on three-dimensional vascular architecture and expression of vascular endothelial growth factor of intrarenal segmental and interlobar arteries in diabetic rat kidney Authors Manaras Komolkriengkrai Division of Health and Applied Sciences Faculty of Science Prince of Songkla University Thailand Rawipa Jangchart Division of Health and Applied Sciences Faculty of Science Prince of Songkla University Thailand Nichawadee Sandech Division of Health and Applied Sciences Faculty of Science Prince of Songkla University Thailand Uraporn Vongvatcharanon Division of Health and Applied Sciences Faculty of Science Prince of Songkla University Thailand Wipapan Khimmaktong Division of Health and Applied Sciences Faculty of Science Prince of Songkla University Thailand DOI: https://doi.org/10.31989/ffhd.v12i6.930 Abstract Background: A high prevalence of atherosclerotic vascular lesions has been associated with renal disease and diabetes and is a major cause for increasing deaths from cardiovascular disease. The present study aimed to determine the beneficial effects of gymnemic acids on the kidney microvasculature and to establish their anti-angiogenic properties that are related to the expression of vascular endothelial growth factor (VEGF) protein of segmental and interlobar arteries in induced diabetic rats.  Methods: Rats were divided into five groups including the control group (C), control treated with gymnemic acid (CGM), diabetic animals (DM group) that were rendered diabetic by a single dose [60 mg/kg body weight (BW)] of a streptozotocin (STZ) injection, diabetic rats treated with gymnemic acid (400 mg/kg BW) (GM), and diabetic rats treated with glibenclamide (4 mg/kg BW) (GR). After 8 weeks, kidney tissues were collected for histological analysis. In rats with DM, the segmental arteries exhibited increased wall thickness. The kidney microvasculature was examined using the vascular corrosion casting method.  Results: Rats with DM presented a decreasing diameter of segmental and interlobar arteries. They were evidently redeveloped and restored in the GM and GR groups. As determined by immunofluorescence, the expression of VEGF was significantly reduced in both the GM and GR groups.  Conclusions: The present study demonstrated that gymnemic acid from Gymnemasylvestre may be a promising medical herb for use in the treatment of diabetes and kidney disease. Keywords: diabetes mellitus, segmental artery, interlobar artery, gymnemic acid, vascular architecture Author Biography Wipapan Khimmaktong, Division of Health and Applied Sciences Faculty of Science Prince of Songkla University Thailand Division of Health and Applied Sciences Faculty of Science Prince of Songkla University Thailand Downloads {Abstract} {Full Article} Published 2022-06-22 Issue Vol. 12 No. 6 (2022): June 2022 Section Research Articles License Authors retain the copyright of their articles and grant the Functional Food Center (FFC) and its journals the right of first publication under the terms of the Creative Commons Attribution 4.0 International License. This license permits unrestricted use, distribution, and reproduction in any medium, including commercial use, provided the original author(s) and source are properly credited. Authors may post and share their published work freely, provided that the original publication in this journal is acknowledged. By submitting to this journal, authors confirm that their manuscripts are original, not under consideration elsewhere, and that they hold the necessary rights to grant this license. The Functional Food Center encourages open scientific exchange and allows derivative and extended works, provided attribution to the original publication is maintained. About the Journal      Editing Services      Graphical Abstract      Journal Insights        Submissions        Editorial Team       Privacy Statement        Contact        Current        Archives   Open Journal Systems Hosting and Support by: OpenJournalSystems.com