Mechanism Prediction of Gastro-protective Effects of the Biebersteinia multifida against Ethanol-Induced Gastric Ulcers; an Insilco study
							| Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007



	

				
						
 
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																Functional Foods in Health and Disease - Online ISSN: 2160-3855; Print ISSN: 2378-7007
										

				


				
				
					
					
						
																					
				
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					Vol. 12 No. 9 (2022): September 2022
				
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									Research Articles
							
		



	
		  	 

		
	
		Mechanism Prediction of Gastro-protective Effects of the Biebersteinia multifida against Ethanol-Induced Gastric Ulcers; an Insilco study
	


	
	
		

							
					Authors

						
							
								Saeed Rezaei Zarchi
							
															
									Assistant professor, Department of Biology, Payame Noor University, Yazd, Iran
																	
																																		
	
							
								Mahdi Dousti
							
															
									Ph.D. of Pathology, Department of pathobiology, School of veterinary medicine, Shiraz University, Shiraz, Iran
																	
																																		
	
							
								Davood Rezazadeh
							
															
									Assistant Professor of Molecular Medicine. Molecular Medicine Department, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
																	
																																		
	
							
								Elham Sajadi
							
															
									Ph.D. of Physiology, Department of Basic Science, School of veterinary medicine, Shiraz University, Shiraz, Iran.
																	
																																		
	
							
								Sara Rizvand
							
															
									MSC of Biophysics, Department of Biology, Payame Noor University, Yazd, Iran
																	
																																		
	
							
								Narges Eskandari Roozbahani
							
															
									Ph.D. Pharmacology, Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
																	
																																		


				
			
																	
					
												DOI:
					

					
						
							https://doi.org/10.31989/ffhd.v12i9.964
						
					
				
			

						
										
					Abstract

					Introduction: Peptic ulcer disease (PUD) is one of the most common diseases of the gastrointestinal tract. Herbal remedies are alternative therapies that have different gastro protective mechanisms, the gastro protective effect of Biebersteinia multifida (BM) was evaluated previously.
Objective: This study was performed to predict the possible mechanism of action of BM bioactive compounds on ameliorating ethanolic PUD in an Insilico study by molecular docking.
Methods: Bioactive compounds in BM were screened by Molegro Virtual Docker 6.0 (MVD) for their effects on factors affecting the healing and progression of ethanolic PUD.
Results: The principal bioactive compound in BM root that has an ameliorating effect in PUD is the flavonoids luteolin rutinoside. This compound establishes the lowest binding energy with the enzymes xanthine oxidase, cyclooxygenase-2, and superoxide dismutase, respectively.
Conclusion: Biebersteinia multifida probably affects the factors involved in ethanolic PUD due to the presence of flavonoids luteolin rutinoside and thus plays a role in the healing of PUD.

Keywords: Molecular Docking, Biebersteinia multifida, Peptic ulcer, Molegro Virtual Docker



				
			
			

						
																																																						
						
		


		

						
										
					
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																			2022-09-09
																	

				
							

			
						
										

											
							
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									Vol. 12 No. 9 (2022): September 2022
								
							

						
					
											
							
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								Research Articles
							

						
					
									

			
						
										
					
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