id	sid	tid	token	lemma	pos
futech-391	1	1	w.	w.	PROPN
futech-391	1	2	li	li	PROPN
futech-391	1	3	&	&	CCONJ
futech-391	1	4	sp	sp	PROPN
futech-391	1	5	.	.	PROPN
futech-391	1	6	chandran	chandran	PROPN
futech-391	1	7	/future	/future	PUNCT
futech-391	1	8	technology	technology	PROPN
futech-391	1	9	august	august	PROPN
futech-391	1	10	2025|	2025|	NUM
futech-391	1	11	volume	volume	NOUN
futech-391	1	12	04	04	NUM
futech-391	2	1	|	|	NOUN
futech-391	2	2	issue	issue	NOUN
futech-391	2	3	03	03	NUM
futech-391	3	1	|	|	ADV
futech-391	3	2	pages	page	NOUN
futech-391	3	3	193	193	NUM
futech-391	3	4	-	-	SYM
futech-391	3	5	203	203	NUM
futech-391	3	6	193	193	NUM
futech-391	3	7	article	article	NOUN
futech-391	3	8	machine	machine	NOUN
futech-391	3	9	learning	learning	NOUN
futech-391	3	10	-	-	PUNCT
futech-391	3	11	based	base	VERB
futech-391	3	12	integration	integration	NOUN
futech-391	3	13	of	of	ADP
futech-391	3	14	multi	multi	ADJ
futech-391	3	15	-	-	ADJ
futech-391	3	16	omics	omics	ADJ
futech-391	3	17	data	datum	NOUN
futech-391	3	18	for	for	ADP
futech-391	3	19	identification	identification	NOUN
futech-391	3	20	of	of	ADP
futech-391	3	21	tubular	tubular	ADJ
futech-391	3	22	epithelial	epithelial	ADJ
futech-391	3	23	cellspecific	cellspecific	NOUN
futech-391	3	24	biomarkers	biomarker	NOUN
futech-391	3	25	in	in	ADP
futech-391	3	26	diabetic	diabetic	ADJ
futech-391	3	27	nephropathy	nephropathy	NOUN
futech-391	3	28	wenning	wenne	VERB
futech-391	3	29	li	li	PROPN
futech-391	3	30	*	*	PROPN
futech-391	3	31	,	,	PUNCT
futech-391	3	32	suriyakala	suriyakala	PROPN
futech-391	3	33	perumal	perumal	PROPN
futech-391	3	34	chandran	chandran	PROPN
futech-391	3	35	faculty	faculty	PROPN
futech-391	3	36	of	of	ADP
futech-391	3	37	medicine	medicine	NOUN
futech-391	3	38	,	,	PUNCT
futech-391	3	39	lincoln	lincoln	PROPN
futech-391	3	40	university	university	PROPN
futech-391	3	41	college	college	PROPN
futech-391	3	42	,	,	PUNCT
futech-391	3	43	petaling	petaling	PROPN
futech-391	3	44	jaya	jaya	PROPN
futech-391	3	45	,	,	PUNCT
futech-391	3	46	darul	darul	PROPN
futech-391	3	47	ehsan	ehsan	PROPN
futech-391	3	48	,	,	PUNCT
futech-391	3	49	selangor	selangor	PROPN
futech-391	3	50	,	,	PUNCT
futech-391	3	51	malaysia	malaysia	PROPN
futech-391	3	52	a	a	DET
futech-391	3	53	r	r	NOUN
futech-391	3	54	t	t	NOUN
futech-391	4	1	i	i	PRON
futech-391	4	2	c	c	NOUN
futech-391	4	3	l	l	NOUN
futech-391	4	4	e	e	NOUN
futech-391	5	1	i	i	PRON
futech-391	5	2	n	n	VERB
futech-391	5	3	f	f	NOUN
futech-391	5	4	o	o	NOUN
futech-391	5	5	article	article	NOUN
futech-391	5	6	history	history	NOUN
futech-391	5	7	:	:	PUNCT
futech-391	5	8	received	receive	VERB
futech-391	5	9	24	24	NUM
futech-391	5	10	april	april	PROPN
futech-391	5	11	2025	2025	NUM
futech-391	5	12	received	receive	VERB
futech-391	5	13	in	in	ADP
futech-391	5	14	revised	revise	VERB
futech-391	5	15	form	form	NOUN
futech-391	5	16	10	10	NUM
futech-391	5	17	june	june	PROPN
futech-391	5	18	2025	2025	NUM
futech-391	5	19	accepted	accept	VERB
futech-391	5	20	16	16	NUM
futech-391	5	21	june	june	PROPN
futech-391	5	22	2025	2025	NUM
futech-391	5	23	keywords	keyword	NOUN
futech-391	5	24	:	:	PUNCT
futech-391	5	25	diabetic	diabetic	ADJ
futech-391	5	26	nephropathy	nephropathy	NOUN
futech-391	5	27	,	,	PUNCT
futech-391	5	28	multi	multi	ADJ
futech-391	5	29	-	-	ADJ
futech-391	5	30	omics	omics	ADJ
futech-391	5	31	integration	integration	NOUN
futech-391	5	32	,	,	PUNCT
futech-391	5	33	tubular	tubular	ADJ
futech-391	5	34	epithelial	epithelial	ADJ
futech-391	5	35	cells	cell	NOUN
futech-391	5	36	,	,	PUNCT
futech-391	5	37	machine	machine	NOUN
futech-391	5	38	learning	learn	VERB
futech-391	5	39	biomarkers	biomarker	NOUN
futech-391	5	40	,	,	PUNCT
futech-391	5	41	ensemble	ensemble	ADJ
futech-391	5	42	algorithms	algorithm	NOUN
futech-391	5	43	*	*	PUNCT
futech-391	5	44	corresponding	correspond	VERB
futech-391	5	45	author	author	NOUN
futech-391	5	46	email	email	NOUN
futech-391	5	47	address	address	NOUN
futech-391	5	48	:	:	PUNCT
futech-391	5	49	limumu998998@126.com	limumu998998@126.com	X
futech-391	6	1	doi	doi	NOUN
futech-391	6	2	:	:	PUNCT
futech-391	6	3	10.55670	10.55670	NUM
futech-391	6	4	/	/	SYM
futech-391	6	5	fpll.futech.4.3.18	fpll.futech.4.3.18	NOUN
futech-391	6	6	a	a	PRON
futech-391	6	7	b	b	PROPN
futech-391	6	8	s	s	ADP
futech-391	6	9	t	t	PROPN
futech-391	6	10	r	r	NOUN
futech-391	6	11	a	a	DET
futech-391	6	12	c	c	NOUN
futech-391	6	13	t	t	PROPN
futech-391	6	14	diabetic	diabetic	ADJ
futech-391	6	15	nephropathy	nephropathy	NOUN
futech-391	6	16	is	be	AUX
futech-391	6	17	a	a	DET
futech-391	6	18	leading	lead	VERB
futech-391	6	19	cause	cause	NOUN
futech-391	6	20	of	of	ADP
futech-391	6	21	end	end	NOUN
futech-391	6	22	-	-	PUNCT
futech-391	6	23	stage	stage	NOUN
futech-391	6	24	renal	renal	ADJ
futech-391	6	25	disease	disease	NOUN
futech-391	6	26	.	.	PUNCT
futech-391	7	1	current	current	ADJ
futech-391	7	2	diagnostic	diagnostic	ADJ
futech-391	7	3	methods	method	NOUN
futech-391	7	4	,	,	PUNCT
futech-391	7	5	which	which	PRON
futech-391	7	6	utilize	utilize	VERB
futech-391	7	7	conventional	conventional	ADJ
futech-391	7	8	biomarkers	biomarker	NOUN
futech-391	7	9	,	,	PUNCT
futech-391	7	10	fail	fail	VERB
futech-391	7	11	to	to	PART
futech-391	7	12	adequately	adequately	ADV
futech-391	7	13	capture	capture	VERB
futech-391	7	14	early	early	ADJ
futech-391	7	15	-	-	PUNCT
futech-391	7	16	stage	stage	NOUN
futech-391	7	17	tubular	tubular	ADJ
futech-391	7	18	epithelial	epithelial	ADJ
futech-391	7	19	cell	cell	NOUN
futech-391	7	20	dysfunction	dysfunction	NOUN
futech-391	7	21	,	,	PUNCT
futech-391	7	22	a	a	DET
futech-391	7	23	condition	condition	NOUN
futech-391	7	24	that	that	PRON
futech-391	7	25	likely	likely	ADV
futech-391	7	26	occurs	occur	VERB
futech-391	7	27	prior	prior	ADV
futech-391	7	28	to	to	ADP
futech-391	7	29	glomerular	glomerular	ADJ
futech-391	7	30	damage	damage	NOUN
futech-391	7	31	.	.	PUNCT
futech-391	8	1	this	this	DET
futech-391	8	2	study	study	NOUN
futech-391	8	3	developed	develop	VERB
futech-391	8	4	a	a	DET
futech-391	8	5	comprehensive	comprehensive	ADJ
futech-391	8	6	machine	machine	NOUN
futech-391	8	7	learning	learn	VERB
futech-391	8	8	framework	framework	NOUN
futech-391	8	9	integrating	integrate	VERB
futech-391	8	10	multi	multi	ADJ
futech-391	8	11	-	-	ADJ
futech-391	8	12	omics	omics	ADJ
futech-391	8	13	data	datum	NOUN
futech-391	8	14	to	to	PART
futech-391	8	15	identify	identify	VERB
futech-391	8	16	tubular	tubular	ADJ
futech-391	8	17	epithelial	epithelial	ADJ
futech-391	8	18	cell	cell	NOUN
futech-391	8	19	-	-	PUNCT
futech-391	8	20	specific	specific	ADJ
futech-391	8	21	biomarkers	biomarker	NOUN
futech-391	8	22	for	for	ADP
futech-391	8	23	diabetic	diabetic	ADJ
futech-391	8	24	nephropathy	nephropathy	NOUN
futech-391	8	25	.	.	PUNCT
futech-391	9	1	we	we	PRON
futech-391	9	2	systematically	systematically	ADV
futech-391	9	3	collected	collect	VERB
futech-391	9	4	omics	omics	PROPN
futech-391	9	5	data	datum	NOUN
futech-391	9	6	from	from	ADP
futech-391	9	7	established	establish	VERB
futech-391	9	8	public	public	ADJ
futech-391	9	9	databases	database	NOUN
futech-391	9	10	,	,	PUNCT
futech-391	9	11	analyzing	analyze	VERB
futech-391	9	12	245	245	NUM
futech-391	9	13	transcriptomic	transcriptomic	ADJ
futech-391	9	14	samples	sample	NOUN
futech-391	9	15	(	(	PUNCT
futech-391	9	16	18,632	18,632	NUM
futech-391	9	17	features	feature	NOUN
futech-391	9	18	)	)	PUNCT
futech-391	9	19	,	,	PUNCT
futech-391	9	20	198	198	NUM
futech-391	9	21	proteomic	proteomic	ADJ
futech-391	9	22	samples	sample	NOUN
futech-391	9	23	(	(	PUNCT
futech-391	9	24	4,521	4,521	NUM
futech-391	9	25	features	feature	NOUN
futech-391	9	26	)	)	PUNCT
futech-391	9	27	,	,	PUNCT
futech-391	9	28	and	and	CCONJ
futech-391	9	29	167	167	NUM
futech-391	9	30	metabolomic	metabolomic	ADJ
futech-391	9	31	samples	sample	NOUN
futech-391	9	32	(	(	PUNCT
futech-391	9	33	812	812	NUM
futech-391	9	34	features	feature	NOUN
futech-391	9	35	)	)	PUNCT
futech-391	9	36	,	,	PUNCT
futech-391	9	37	resulting	result	VERB
futech-391	9	38	in	in	ADP
futech-391	9	39	an	an	DET
futech-391	9	40	integrated	integrate	VERB
futech-391	9	41	dataset	dataset	NOUN
futech-391	9	42	of	of	ADP
futech-391	9	43	156	156	NUM
futech-391	9	44	samples	sample	NOUN
futech-391	9	45	with	with	ADP
futech-391	9	46	23,965	23,965	NUM
futech-391	9	47	molecular	molecular	ADJ
futech-391	9	48	features	feature	NOUN
futech-391	9	49	.	.	PUNCT
futech-391	10	1	following	follow	VERB
futech-391	10	2	stringent	stringent	ADJ
futech-391	10	3	quality	quality	NOUN
futech-391	10	4	control	control	NOUN
futech-391	10	5	,	,	PUNCT
futech-391	10	6	batch	batch	NOUN
futech-391	10	7	effect	effect	NOUN
futech-391	10	8	removal	removal	NOUN
futech-391	10	9	,	,	PUNCT
futech-391	10	10	and	and	CCONJ
futech-391	10	11	normalization	normalization	NOUN
futech-391	10	12	,	,	PUNCT
futech-391	10	13	we	we	PRON
futech-391	10	14	implemented	implement	VERB
futech-391	10	15	an	an	DET
futech-391	10	16	ensemble	ensemble	ADJ
futech-391	10	17	learning	learning	NOUN
futech-391	10	18	approach	approach	NOUN
futech-391	10	19	combining	combine	VERB
futech-391	10	20	random	random	ADJ
futech-391	10	21	forest	forest	NOUN
futech-391	10	22	,	,	PUNCT
futech-391	10	23	support	support	VERB
futech-391	10	24	vector	vector	NOUN
futech-391	10	25	machine	machine	NOUN
futech-391	10	26	,	,	PUNCT
futech-391	10	27	and	and	CCONJ
futech-391	10	28	xgboost	xgboost	ADV
futech-391	10	29	algorithms	algorithm	NOUN
futech-391	10	30	.	.	PUNCT
futech-391	11	1	the	the	DET
futech-391	11	2	ensemble	ensemble	ADJ
futech-391	11	3	model	model	NOUN
futech-391	11	4	achieved	achieve	VERB
futech-391	11	5	superior	superior	ADJ
futech-391	11	6	performance	performance	NOUN
futech-391	11	7	with	with	ADP
futech-391	11	8	91.4	91.4	NUM
futech-391	11	9	%	%	NOUN
futech-391	11	10	accuracy	accuracy	NOUN
futech-391	11	11	,	,	PUNCT
futech-391	11	12	89.6	89.6	NUM
futech-391	11	13	%	%	NOUN
futech-391	11	14	sensitivity	sensitivity	NOUN
futech-391	11	15	,	,	PUNCT
futech-391	11	16	92.8	92.8	NUM
futech-391	11	17	%	%	NOUN
futech-391	11	18	specificity	specificity	NOUN
futech-391	11	19	,	,	PUNCT
futech-391	11	20	and	and	CCONJ
futech-391	11	21	an	an	DET
futech-391	11	22	auc	auc	NOUN
futech-391	11	23	of	of	ADP
futech-391	11	24	0.947	0.947	NUM
futech-391	11	25	,	,	PUNCT
futech-391	11	26	representing	represent	VERB
futech-391	11	27	significant	significant	ADJ
futech-391	11	28	improvement	improvement	NOUN
futech-391	11	29	over	over	ADP
futech-391	11	30	conventional	conventional	ADJ
futech-391	11	31	clinical	clinical	ADJ
futech-391	11	32	markers	marker	NOUN
futech-391	11	33	.	.	PUNCT
futech-391	12	1	we	we	PRON
futech-391	12	2	identified	identify	VERB
futech-391	12	3	ten	ten	NUM
futech-391	12	4	tubular	tubular	ADJ
futech-391	12	5	epithelial	epithelial	ADJ
futech-391	12	6	cell	cell	NOUN
futech-391	12	7	-	-	PUNCT
futech-391	12	8	specific	specific	ADJ
futech-391	12	9	candidate	candidate	NOUN
futech-391	12	10	biomarkers	biomarker	NOUN
futech-391	12	11	,	,	PUNCT
futech-391	12	12	with	with	ADP
futech-391	12	13	kim-1	kim-1	VERB
futech-391	12	14	showing	show	VERB
futech-391	12	15	the	the	DET
futech-391	12	16	highest	high	ADJ
futech-391	12	17	importance	importance	NOUN
futech-391	12	18	score	score	NOUN
futech-391	12	19	(	(	PUNCT
futech-391	12	20	0.092	0.092	NUM
futech-391	12	21	)	)	PUNCT
futech-391	12	22	,	,	PUNCT
futech-391	12	23	followed	follow	VERB
futech-391	12	24	by	by	ADP
futech-391	12	25	ngal	ngal	ADJ
futech-391	12	26	(	(	PUNCT
futech-391	12	27	0.087	0.087	NUM
futech-391	12	28	)	)	PUNCT
futech-391	12	29	and	and	CCONJ
futech-391	12	30	l	l	NOUN
futech-391	12	31	-	-	NOUN
futech-391	12	32	fabp	fabp	PROPN
futech-391	12	33	(	(	PUNCT
futech-391	12	34	0.084	0.084	NUM
futech-391	12	35	)	)	PUNCT
futech-391	12	36	.	.	PUNCT
futech-391	13	1	these	these	DET
futech-391	13	2	markers	marker	NOUN
futech-391	13	3	demonstrated	demonstrate	VERB
futech-391	13	4	progressive	progressive	ADJ
futech-391	13	5	upregulation	upregulation	NOUN
futech-391	13	6	throughout	throughout	ADP
futech-391	13	7	disease	disease	NOUN
futech-391	13	8	stages	stage	NOUN
futech-391	13	9	with	with	ADP
futech-391	13	10	1.5fold	1.5fold	NUM
futech-391	13	11	to	to	PART
futech-391	13	12	3.2	3.2	NUM
futech-391	13	13	-	-	ADJ
futech-391	13	14	fold	fold	ADJ
futech-391	13	15	increases	increase	NOUN
futech-391	13	16	in	in	ADP
futech-391	13	17	advanced	advanced	ADJ
futech-391	13	18	states	state	NOUN
futech-391	13	19	.	.	PUNCT
futech-391	14	1	analysis	analysis	NOUN
futech-391	14	2	revealed	reveal	VERB
futech-391	14	3	perturbations	perturbation	NOUN
futech-391	14	4	in	in	ADP
futech-391	14	5	inflammatory	inflammatory	ADJ
futech-391	14	6	response	response	NOUN
futech-391	14	7	pathways	pathway	NOUN
futech-391	14	8	,	,	PUNCT
futech-391	14	9	oxidative	oxidative	ADJ
futech-391	14	10	stress	stress	NOUN
futech-391	14	11	processes	process	NOUN
futech-391	14	12	,	,	PUNCT
futech-391	14	13	and	and	CCONJ
futech-391	14	14	epithelial	epithelial	ADJ
futech-391	14	15	-	-	PUNCT
futech-391	14	16	tomesenchymal	tomesenchymal	ADJ
futech-391	14	17	transition	transition	NOUN
futech-391	14	18	.	.	PUNCT
futech-391	15	1	independent	independent	ADJ
futech-391	15	2	cohort	cohort	NOUN
futech-391	15	3	validation	validation	NOUN
futech-391	15	4	across	across	ADP
futech-391	15	5	three	three	NUM
futech-391	15	6	geographically	geographically	ADV
futech-391	15	7	distinct	distinct	ADJ
futech-391	15	8	populations	population	NOUN
futech-391	15	9	confirmed	confirm	VERB
futech-391	15	10	the	the	DET
futech-391	15	11	robustness	robustness	NOUN
futech-391	15	12	and	and	CCONJ
futech-391	15	13	generalizability	generalizability	NOUN
futech-391	15	14	of	of	ADP
futech-391	15	15	identified	identify	VERB
futech-391	15	16	biomarkers	biomarker	NOUN
futech-391	15	17	.	.	PUNCT
futech-391	16	1	the	the	DET
futech-391	16	2	findings	finding	NOUN
futech-391	16	3	demonstrate	demonstrate	VERB
futech-391	16	4	the	the	DET
futech-391	16	5	potential	potential	NOUN
futech-391	16	6	of	of	ADP
futech-391	16	7	machine	machine	NOUN
futech-391	16	8	learning	learning	NOUN
futech-391	16	9	-	-	PUNCT
futech-391	16	10	based	base	VERB
futech-391	16	11	multi	multi	ADJ
futech-391	16	12	-	-	ADJ
futech-391	16	13	omics	omics	ADJ
futech-391	16	14	integration	integration	NOUN
futech-391	16	15	for	for	ADP
futech-391	16	16	enhanced	enhanced	ADJ
futech-391	16	17	diabetic	diabetic	ADJ
futech-391	16	18	nephropathy	nephropathy	ADJ
futech-391	16	19	detection	detection	NOUN
futech-391	16	20	and	and	CCONJ
futech-391	16	21	provide	provide	VERB
futech-391	16	22	novel	novel	ADJ
futech-391	16	23	insights	insight	NOUN
futech-391	16	24	into	into	ADP
futech-391	16	25	tubular	tubular	ADJ
futech-391	16	26	pathophysiology	pathophysiology	NOUN
futech-391	16	27	that	that	PRON
futech-391	16	28	could	could	AUX
futech-391	16	29	facilitate	facilitate	VERB
futech-391	16	30	earlier	early	ADJ
futech-391	16	31	intervention	intervention	NOUN
futech-391	16	32	and	and	CCONJ
futech-391	16	33	personalized	personalized	ADJ
futech-391	16	34	treatment	treatment	NOUN
futech-391	16	35	strategies	strategy	NOUN
futech-391	16	36	.	.	PUNCT
futech-391	17	1	1	1	X
futech-391	17	2	.	.	X
futech-391	17	3	introduction	introduction	NOUN
futech-391	17	4	diabetic	diabetic	ADJ
futech-391	17	5	nephropathy	nephropathy	NOUN
futech-391	17	6	(	(	PUNCT
futech-391	17	7	dn	dn	NOUN
futech-391	17	8	)	)	PUNCT
futech-391	17	9	is	be	AUX
futech-391	17	10	a	a	DET
futech-391	17	11	severe	severe	ADJ
futech-391	17	12	microvascular	microvascular	NOUN
futech-391	17	13	complication	complication	NOUN
futech-391	17	14	of	of	ADP
futech-391	17	15	diabetes	diabetes	NOUN
futech-391	17	16	mellitus	mellitus	NOUN
futech-391	17	17	,	,	PUNCT
futech-391	17	18	characterized	characterize	VERB
futech-391	17	19	by	by	ADP
futech-391	17	20	progressive	progressive	ADJ
futech-391	17	21	kidney	kidney	PROPN
futech-391	17	22	structural	structural	ADJ
futech-391	17	23	and	and	CCONJ
futech-391	17	24	functional	functional	ADJ
futech-391	17	25	deterioration	deterioration	NOUN
futech-391	17	26	that	that	PRON
futech-391	17	27	ultimately	ultimately	ADV
futech-391	17	28	leads	lead	VERB
futech-391	17	29	to	to	ADP
futech-391	17	30	end	end	NOUN
futech-391	17	31	-	-	PUNCT
futech-391	17	32	stage	stage	NOUN
futech-391	17	33	renal	renal	ADJ
futech-391	17	34	disease	disease	NOUN
futech-391	17	35	[	[	X
futech-391	17	36	1	1	NUM
futech-391	17	37	]	]	PUNCT
futech-391	17	38	.	.	PUNCT
futech-391	18	1	the	the	DET
futech-391	18	2	pathophysiology	pathophysiology	NOUN
futech-391	18	3	of	of	ADP
futech-391	18	4	dn	dn	NOUN
futech-391	18	5	involves	involve	VERB
futech-391	18	6	complex	complex	ADJ
futech-391	18	7	interactions	interaction	NOUN
futech-391	18	8	between	between	ADP
futech-391	18	9	metabolic	metabolic	NOUN
futech-391	18	10	,	,	PUNCT
futech-391	18	11	hemodynamic	hemodynamic	ADJ
futech-391	18	12	,	,	PUNCT
futech-391	18	13	and	and	CCONJ
futech-391	18	14	inflammatory	inflammatory	ADJ
futech-391	18	15	pathways	pathway	NOUN
futech-391	18	16	that	that	PRON
futech-391	18	17	affect	affect	VERB
futech-391	18	18	all	all	DET
futech-391	18	19	components	component	NOUN
futech-391	18	20	of	of	ADP
futech-391	18	21	the	the	DET
futech-391	18	22	nephron	nephron	NOUN
futech-391	18	23	,	,	PUNCT
futech-391	18	24	including	include	VERB
futech-391	18	25	glomerular	glomerular	ADJ
futech-391	18	26	endothelial	endothelial	ADJ
futech-391	18	27	cells	cell	NOUN
futech-391	18	28	,	,	PUNCT
futech-391	18	29	mesangial	mesangial	ADJ
futech-391	18	30	cells	cell	NOUN
futech-391	18	31	,	,	PUNCT
futech-391	18	32	podocytes	podocyte	NOUN
futech-391	18	33	,	,	PUNCT
futech-391	18	34	and	and	CCONJ
futech-391	18	35	critically	critically	ADV
futech-391	18	36	,	,	PUNCT
futech-391	18	37	tubular	tubular	ADJ
futech-391	18	38	epithelial	epithelial	ADJ
futech-391	18	39	cells	cell	NOUN
futech-391	18	40	[	[	X
futech-391	18	41	2	2	NUM
futech-391	18	42	]	]	PUNCT
futech-391	18	43	.	.	PUNCT
futech-391	19	1	recent	recent	ADJ
futech-391	19	2	evidence	evidence	NOUN
futech-391	19	3	suggests	suggest	VERB
futech-391	19	4	that	that	SCONJ
futech-391	19	5	tubular	tubular	ADJ
futech-391	19	6	injury	injury	NOUN
futech-391	19	7	may	may	AUX
futech-391	19	8	occur	occur	VERB
futech-391	19	9	independently	independently	ADV
futech-391	19	10	of	of	ADP
futech-391	19	11	,	,	PUNCT
futech-391	19	12	and	and	CCONJ
futech-391	19	13	even	even	ADV
futech-391	19	14	precede	precede	VERB
futech-391	19	15	,	,	PUNCT
futech-391	19	16	glomerular	glomerular	ADJ
futech-391	19	17	damage	damage	NOUN
futech-391	19	18	,	,	PUNCT
futech-391	19	19	challenging	challenge	VERB
futech-391	19	20	the	the	DET
futech-391	19	21	traditional	traditional	ADJ
futech-391	19	22	glomerulus	glomerulus	NOUN
futech-391	19	23	-	-	PUNCT
futech-391	19	24	centric	centric	ADJ
futech-391	19	25	view	view	NOUN
futech-391	19	26	of	of	ADP
futech-391	19	27	dn	dn	PROPN
futech-391	19	28	pathogenesis	pathogenesis	NOUN
futech-391	19	29	[	[	X
futech-391	19	30	3	3	NUM
futech-391	19	31	]	]	PUNCT
futech-391	19	32	.	.	PUNCT
futech-391	20	1	current	current	ADJ
futech-391	20	2	diagnostic	diagnostic	ADJ
futech-391	20	3	approaches	approach	NOUN
futech-391	20	4	primarily	primarily	ADV
futech-391	20	5	rely	rely	VERB
futech-391	20	6	on	on	ADP
futech-391	20	7	albuminuria	albuminuria	NOUN
futech-391	20	8	and	and	CCONJ
futech-391	20	9	estimated	estimate	VERB
futech-391	20	10	glomerular	glomerular	ADJ
futech-391	20	11	filtration	filtration	NOUN
futech-391	20	12	rate	rate	NOUN
futech-391	20	13	;	;	PUNCT
futech-391	20	14	however	however	ADV
futech-391	20	15	,	,	PUNCT
futech-391	20	16	these	these	DET
futech-391	20	17	conventional	conventional	ADJ
futech-391	20	18	biomarkers	biomarker	NOUN
futech-391	20	19	demonstrate	demonstrate	VERB
futech-391	20	20	significant	significant	ADJ
futech-391	20	21	limitations	limitation	NOUN
futech-391	20	22	in	in	ADP
futech-391	20	23	sensitivity	sensitivity	NOUN
futech-391	20	24	and	and	CCONJ
futech-391	20	25	specificity	specificity	NOUN
futech-391	20	26	for	for	ADP
futech-391	20	27	early	early	ADJ
futech-391	20	28	disease	disease	NOUN
futech-391	20	29	detection	detection	NOUN
futech-391	20	30	,	,	PUNCT
futech-391	20	31	particularly	particularly	ADV
futech-391	20	32	in	in	ADP
futech-391	20	33	capturing	capture	VERB
futech-391	20	34	the	the	DET
futech-391	20	35	full	full	ADJ
futech-391	20	36	spectrum	spectrum	NOUN
futech-391	20	37	of	of	ADP
futech-391	20	38	tubulointerstitial	tubulointerstitial	ADJ
futech-391	20	39	pathology	pathology	NOUN
futech-391	20	40	[	[	X
futech-391	20	41	4	4	NUM
futech-391	20	42	]	]	PUNCT
futech-391	20	43	.	.	PUNCT
futech-391	21	1	the	the	DET
futech-391	21	2	inadequacy	inadequacy	NOUN
futech-391	21	3	of	of	ADP
futech-391	21	4	existing	exist	VERB
futech-391	21	5	biomarkers	biomarker	NOUN
futech-391	21	6	has	have	AUX
futech-391	21	7	prompted	prompt	VERB
futech-391	21	8	intensive	intensive	ADJ
futech-391	21	9	research	research	NOUN
futech-391	21	10	efforts	effort	NOUN
futech-391	21	11	to	to	PART
futech-391	21	12	identify	identify	VERB
futech-391	21	13	novel	novel	NOUN
futech-391	21	14	,	,	PUNCT
futech-391	21	15	more	more	ADV
futech-391	21	16	sensitive	sensitive	ADJ
futech-391	21	17	indicators	indicator	NOUN
futech-391	21	18	that	that	PRON
futech-391	21	19	can	can	AUX
futech-391	21	20	facilitate	facilitate	VERB
futech-391	21	21	earlier	early	ADJ
futech-391	21	22	intervention	intervention	NOUN
futech-391	21	23	and	and	CCONJ
futech-391	21	24	improved	improve	VERB
futech-391	21	25	patient	patient	ADJ
futech-391	21	26	outcomes	outcome	NOUN
futech-391	21	27	[	[	X
futech-391	21	28	5	5	NUM
futech-391	21	29	]	]	PUNCT
futech-391	21	30	.	.	PUNCT
futech-391	22	1	current	current	ADJ
futech-391	22	2	diagnostic	diagnostic	ADJ
futech-391	22	3	approaches	approach	NOUN
futech-391	22	4	for	for	ADP
futech-391	22	5	diabetic	diabetic	ADJ
futech-391	22	6	nephropathy	nephropathy	NOUN
futech-391	22	7	face	face	VERB
futech-391	22	8	significant	significant	ADJ
futech-391	22	9	limitations	limitation	NOUN
futech-391	22	10	that	that	PRON
futech-391	22	11	impede	impede	VERB
futech-391	22	12	early	early	ADJ
futech-391	22	13	detection	detection	NOUN
futech-391	22	14	and	and	CCONJ
futech-391	22	15	optimal	optimal	ADJ
futech-391	22	16	patient	patient	ADJ
futech-391	22	17	management	management	NOUN
futech-391	22	18	.	.	PUNCT
futech-391	23	1	recent	recent	ADJ
futech-391	23	2	comprehensive	comprehensive	ADJ
futech-391	23	3	reviews	review	NOUN
futech-391	23	4	have	have	AUX
futech-391	23	5	highlighted	highlight	VERB
futech-391	23	6	that	that	SCONJ
futech-391	23	7	conventional	conventional	ADJ
futech-391	23	8	biomarkers	biomarker	NOUN
futech-391	23	9	demonstrate	demonstrate	VERB
futech-391	23	10	inadequate	inadequate	ADJ
futech-391	23	11	sensitivity	sensitivity	NOUN
futech-391	23	12	for	for	ADP
futech-391	23	13	capturing	capture	VERB
futech-391	23	14	early	early	ADJ
futech-391	23	15	-	-	PUNCT
futech-391	23	16	stage	stage	NOUN
futech-391	23	17	disease	disease	NOUN
futech-391	23	18	[	[	X
futech-391	23	19	6	6	NUM
futech-391	23	20	]	]	PUNCT
futech-391	23	21	.	.	PUNCT
futech-391	24	1	traditional	traditional	ADJ
futech-391	24	2	markers	marker	NOUN
futech-391	24	3	,	,	PUNCT
futech-391	24	4	such	such	ADJ
futech-391	24	5	as	as	ADP
futech-391	24	6	serum	serum	NOUN
futech-391	24	7	creatinine	creatinine	NOUN
futech-391	24	8	and	and	CCONJ
futech-391	24	9	the	the	DET
futech-391	24	10	open	open	ADJ
futech-391	24	11	access	access	NOUN
futech-391	24	12	journal	journal	PROPN
futech-391	24	13	issn	issn	PROPN
futech-391	24	14	2832	2832	NUM
futech-391	24	15	-	-	SYM
futech-391	24	16	0379	0379	NUM
futech-391	24	17	https://doi.org/10.55670/fpll.futech.4.3.18	https://doi.org/10.55670/fpll.futech.4.3.18	NOUN
futech-391	24	18	journal	journal	NOUN
futech-391	24	19	homepage	homepage	NOUN
futech-391	24	20	:	:	PUNCT
futech-391	25	1	https://fupubco.com/futech	https://fupubco.com/futech	PROPN
futech-391	25	2	future	future	ADJ
futech-391	25	3	technology	technology	NOUN
futech-391	25	4	open	open	ADJ
futech-391	25	5	access	access	NOUN
futech-391	25	6	journal	journal	PROPN
futech-391	25	7	august	august	PROPN
futech-391	25	8	2025|	2025|	NUM
futech-391	25	9	volume	volume	NOUN
futech-391	25	10	04	04	NUM
futech-391	26	1	|	|	NOUN
futech-391	26	2	issue	issue	NOUN
futech-391	26	3	03	03	NUM
futech-391	27	1	|	|	ADV
futech-391	27	2	pages	page	NOUN
futech-391	27	3	193	193	NUM
futech-391	27	4	-	-	SYM
futech-391	27	5	203	203	NUM
futech-391	27	6	mailto:limumu998998@126.com	mailto:limumu998998@126.com	NUM
futech-391	27	7	https://doi.org/10.55670/fpll.futech.4.3.18	https://doi.org/10.55670/fpll.futech.4.3.18	NOUN
futech-391	27	8	https://fupubco.com/futech	https://fupubco.com/futech	PROPN
futech-391	27	9	w.	w.	PROPN
futech-391	27	10	li	li	PROPN
futech-391	27	11	&	&	CCONJ
futech-391	27	12	sp	sp	PROPN
futech-391	27	13	.	.	PROPN
futech-391	27	14	chandran	chandran	PROPN
futech-391	27	15	/future	/future	PUNCT
futech-391	27	16	technology	technology	PROPN
futech-391	27	17	august	august	PROPN
futech-391	27	18	2025|	2025|	NUM
futech-391	28	1	volume	volume	NOUN
futech-391	28	2	04	04	NUM
futech-391	29	1	|	|	NOUN
futech-391	29	2	issue	issue	NOUN
futech-391	29	3	03	03	NUM
futech-391	30	1	|	|	ADV
futech-391	30	2	pages	page	NOUN
futech-391	30	3	193	193	NUM
futech-391	30	4	-	-	SYM
futech-391	30	5	203	203	NUM
futech-391	30	6	194	194	NUM
futech-391	30	7	albumin	albumin	NOUN
futech-391	30	8	-	-	PUNCT
futech-391	30	9	to	to	ADP
futech-391	30	10	-	-	PUNCT
futech-391	30	11	creatinine	creatinine	NOUN
futech-391	30	12	ratio	ratio	NOUN
futech-391	30	13	,	,	PUNCT
futech-391	30	14	fail	fail	VERB
futech-391	30	15	to	to	PART
futech-391	30	16	adequately	adequately	ADV
futech-391	30	17	reflect	reflect	VERB
futech-391	30	18	the	the	DET
futech-391	30	19	complex	complex	ADJ
futech-391	30	20	pathophysiologic	pathophysiologic	ADJ
futech-391	30	21	mechanisms	mechanism	NOUN
futech-391	30	22	underlying	underlie	VERB
futech-391	30	23	diabetic	diabetic	ADJ
futech-391	30	24	kidney	kidney	NOUN
futech-391	30	25	disease	disease	NOUN
futech-391	30	26	[	[	X
futech-391	30	27	4	4	NUM
futech-391	30	28	]	]	PUNCT
futech-391	30	29	.	.	PUNCT
futech-391	31	1	critical	critical	ADJ
futech-391	31	2	gaps	gap	NOUN
futech-391	31	3	exist	exist	VERB
futech-391	31	4	in	in	ADP
futech-391	31	5	current	current	ADJ
futech-391	31	6	biomarker	biomarker	NOUN
futech-391	31	7	strategies	strategy	NOUN
futech-391	31	8	,	,	PUNCT
futech-391	31	9	with	with	ADP
futech-391	31	10	existing	exist	VERB
futech-391	31	11	approaches	approach	NOUN
futech-391	31	12	often	often	ADV
futech-391	31	13	missing	miss	VERB
futech-391	31	14	the	the	DET
futech-391	31	15	window	window	NOUN
futech-391	31	16	for	for	ADP
futech-391	31	17	early	early	ADJ
futech-391	31	18	therapeutic	therapeutic	ADJ
futech-391	31	19	intervention	intervention	NOUN
futech-391	31	20	when	when	SCONJ
futech-391	31	21	treatment	treatment	NOUN
futech-391	31	22	could	could	AUX
futech-391	31	23	be	be	AUX
futech-391	31	24	most	most	ADV
futech-391	31	25	effective	effective	ADJ
futech-391	31	26	[	[	X
futech-391	31	27	7	7	NUM
futech-391	31	28	]	]	PUNCT
futech-391	31	29	.	.	PUNCT
futech-391	32	1	these	these	DET
futech-391	32	2	diagnostic	diagnostic	ADJ
futech-391	32	3	limitations	limitation	NOUN
futech-391	32	4	contribute	contribute	VERB
futech-391	32	5	to	to	ADP
futech-391	32	6	the	the	DET
futech-391	32	7	delayed	delay	VERB
futech-391	32	8	recognition	recognition	NOUN
futech-391	32	9	of	of	ADP
futech-391	32	10	kidney	kidney	NOUN
futech-391	32	11	dysfunction	dysfunction	NOUN
futech-391	32	12	,	,	PUNCT
futech-391	32	13	often	often	ADV
futech-391	32	14	occurring	occur	VERB
futech-391	32	15	only	only	ADV
futech-391	32	16	after	after	SCONJ
futech-391	32	17	substantial	substantial	ADJ
futech-391	32	18	irreversible	irreversible	ADJ
futech-391	32	19	damage	damage	NOUN
futech-391	32	20	has	have	AUX
futech-391	32	21	occurred	occur	VERB
futech-391	32	22	[	[	X
futech-391	32	23	1	1	NUM
futech-391	32	24	]	]	PUNCT
futech-391	32	25	.	.	PUNCT
futech-391	33	1	the	the	DET
futech-391	33	2	inadequacy	inadequacy	NOUN
futech-391	33	3	of	of	ADP
futech-391	33	4	current	current	ADJ
futech-391	33	5	diagnostic	diagnostic	ADJ
futech-391	33	6	methods	method	NOUN
futech-391	33	7	has	have	AUX
futech-391	33	8	prompted	prompt	VERB
futech-391	33	9	intensive	intensive	ADJ
futech-391	33	10	research	research	NOUN
futech-391	33	11	efforts	effort	NOUN
futech-391	33	12	to	to	PART
futech-391	33	13	identify	identify	VERB
futech-391	33	14	novel	novel	NOUN
futech-391	33	15	,	,	PUNCT
futech-391	33	16	more	more	ADV
futech-391	33	17	sensitive	sensitive	ADJ
futech-391	33	18	biomarkers	biomarker	NOUN
futech-391	33	19	that	that	PRON
futech-391	33	20	can	can	AUX
futech-391	33	21	facilitate	facilitate	VERB
futech-391	33	22	earlier	early	ADJ
futech-391	33	23	intervention	intervention	NOUN
futech-391	33	24	and	and	CCONJ
futech-391	33	25	improve	improve	VERB
futech-391	33	26	patient	patient	ADJ
futech-391	33	27	outcomes	outcome	NOUN
futech-391	33	28	.	.	PUNCT
futech-391	34	1	high	high	ADJ
futech-391	34	2	-	-	PUNCT
futech-391	34	3	throughput	throughput	NOUN
futech-391	34	4	omics	omic	NOUN
futech-391	34	5	technologies	technology	NOUN
futech-391	34	6	have	have	AUX
futech-391	34	7	revolutionized	revolutionize	VERB
futech-391	34	8	biomarker	biomarker	NOUN
futech-391	34	9	discovery	discovery	NOUN
futech-391	34	10	in	in	ADP
futech-391	34	11	nephrology	nephrology	NOUN
futech-391	34	12	by	by	ADP
futech-391	34	13	enabling	enable	VERB
futech-391	34	14	comprehensive	comprehensive	ADJ
futech-391	34	15	molecular	molecular	ADJ
futech-391	34	16	profiling	profiling	NOUN
futech-391	34	17	of	of	ADP
futech-391	34	18	disease	disease	NOUN
futech-391	34	19	states	state	NOUN
futech-391	34	20	[	[	X
futech-391	34	21	8	8	NUM
futech-391	34	22	]	]	PUNCT
futech-391	34	23	.	.	PUNCT
futech-391	35	1	multi	multi	ADJ
futech-391	35	2	-	-	ADJ
futech-391	35	3	omics	omics	ADJ
futech-391	35	4	approaches	approach	NOUN
futech-391	35	5	,	,	PUNCT
futech-391	35	6	such	such	ADJ
futech-391	35	7	as	as	ADP
futech-391	35	8	genomics	genomics	NOUN
futech-391	35	9	,	,	PUNCT
futech-391	35	10	transcriptomics	transcriptomic	NOUN
futech-391	35	11	,	,	PUNCT
futech-391	35	12	proteomics	proteomic	NOUN
futech-391	35	13	,	,	PUNCT
futech-391	35	14	and	and	CCONJ
futech-391	35	15	metabolomics	metabolomic	NOUN
futech-391	35	16	,	,	PUNCT
futech-391	35	17	provide	provide	VERB
futech-391	35	18	unprecedented	unprecedented	ADJ
futech-391	35	19	routes	route	NOUN
futech-391	35	20	to	to	PART
futech-391	35	21	untangle	untangle	VERB
futech-391	35	22	the	the	DET
futech-391	35	23	complex	complex	ADJ
futech-391	35	24	molecular	molecular	ADJ
futech-391	35	25	fingerprints	fingerprint	NOUN
futech-391	35	26	of	of	ADP
futech-391	35	27	dn	dn	ADJ
futech-391	35	28	progression	progression	NOUN
futech-391	35	29	[	[	X
futech-391	35	30	9	9	NUM
futech-391	35	31	]	]	PUNCT
futech-391	35	32	.	.	PUNCT
futech-391	36	1	these	these	DET
futech-391	36	2	technologies	technology	NOUN
futech-391	36	3	provide	provide	VERB
futech-391	36	4	complementary	complementary	ADJ
futech-391	36	5	insights	insight	NOUN
futech-391	36	6	into	into	ADP
futech-391	36	7	disease	disease	NOUN
futech-391	36	8	pathophysiology	pathophysiology	NOUN
futech-391	36	9	,	,	PUNCT
futech-391	36	10	with	with	ADP
futech-391	36	11	each	each	DET
futech-391	36	12	omics	omic	NOUN
futech-391	36	13	layer	layer	NOUN
futech-391	36	14	yielding	yield	VERB
futech-391	36	15	novel	novel	ADJ
futech-391	36	16	information	information	NOUN
futech-391	36	17	about	about	ADP
futech-391	36	18	the	the	DET
futech-391	36	19	biological	biological	ADJ
futech-391	36	20	processes	process	NOUN
futech-391	36	21	underlying	underlie	VERB
futech-391	36	22	kidney	kidney	NOUN
futech-391	36	23	injury	injury	NOUN
futech-391	37	1	[	[	X
futech-391	37	2	10	10	NUM
futech-391	37	3	]	]	PUNCT
futech-391	37	4	.	.	PUNCT
futech-391	38	1	proteomics	proteomic	NOUN
futech-391	38	2	detects	detect	NOUN
futech-391	38	3	functional	functional	ADJ
futech-391	38	4	protein	protein	NOUN
futech-391	38	5	alterations	alteration	NOUN
futech-391	38	6	and	and	CCONJ
futech-391	38	7	pathway	pathway	NOUN
futech-391	38	8	dysregulation	dysregulation	NOUN
futech-391	38	9	,	,	PUNCT
futech-391	38	10	metabolomics	metabolomic	NOUN
futech-391	38	11	identifies	identify	VERB
futech-391	38	12	downstream	downstream	ADJ
futech-391	38	13	biochemical	biochemical	ADJ
futech-391	38	14	derangements	derangement	NOUN
futech-391	38	15	,	,	PUNCT
futech-391	38	16	and	and	CCONJ
futech-391	38	17	transcriptomics	transcriptomic	NOUN
futech-391	38	18	elucidates	elucidate	VERB
futech-391	38	19	gene	gene	NOUN
futech-391	38	20	expression	expression	NOUN
futech-391	38	21	changes	change	VERB
futech-391	38	22	underlying	underlie	VERB
futech-391	38	23	cellular	cellular	ADJ
futech-391	38	24	stress	stress	NOUN
futech-391	38	25	responses	response	NOUN
futech-391	38	26	[	[	X
futech-391	38	27	11	11	NUM
futech-391	38	28	]	]	PUNCT
futech-391	38	29	.	.	PUNCT
futech-391	39	1	merging	merge	VERB
futech-391	39	2	these	these	DET
futech-391	39	3	disparate	disparate	ADJ
futech-391	39	4	data	datum	NOUN
futech-391	39	5	types	type	NOUN
futech-391	39	6	may	may	AUX
futech-391	39	7	potentially	potentially	ADV
futech-391	39	8	overcome	overcome	VERB
futech-391	39	9	the	the	DET
futech-391	39	10	confines	confine	NOUN
futech-391	39	11	of	of	ADP
futech-391	39	12	single	single	ADJ
futech-391	39	13	-	-	PUNCT
futech-391	39	14	biomarker	biomarker	NOUN
futech-391	39	15	strategies	strategy	NOUN
futech-391	39	16	and	and	CCONJ
futech-391	39	17	provide	provide	VERB
futech-391	39	18	a	a	DET
futech-391	39	19	more	more	ADV
futech-391	39	20	comprehensive	comprehensive	ADJ
futech-391	39	21	view	view	NOUN
futech-391	39	22	of	of	ADP
futech-391	39	23	dn	dn	PROPN
futech-391	39	24	pathogenesis	pathogenesis	NOUN
futech-391	39	25	[	[	X
futech-391	39	26	12	12	NUM
futech-391	39	27	]	]	PUNCT
futech-391	39	28	.	.	PUNCT
futech-391	40	1	besides	besides	SCONJ
futech-391	40	2	,	,	PUNCT
futech-391	40	3	advancements	advancement	NOUN
futech-391	40	4	in	in	ADP
futech-391	40	5	spatial	spatial	ADJ
futech-391	40	6	omics	omic	NOUN
futech-391	40	7	and	and	CCONJ
futech-391	40	8	single	single	ADJ
futech-391	40	9	-	-	PUNCT
futech-391	40	10	cell	cell	NOUN
futech-391	40	11	platforms	platform	NOUN
futech-391	40	12	have	have	AUX
futech-391	40	13	enhanced	enhance	VERB
futech-391	40	14	our	our	PRON
futech-391	40	15	ability	ability	NOUN
futech-391	40	16	to	to	PART
futech-391	40	17	probe	probe	VERB
futech-391	40	18	cell	cell	NOUN
futech-391	40	19	-	-	PUNCT
futech-391	40	20	type	type	NOUN
futech-391	40	21	-	-	PUNCT
futech-391	40	22	specific	specific	ADJ
futech-391	40	23	alterations	alteration	NOUN
futech-391	40	24	,	,	PUNCT
futech-391	40	25	particularly	particularly	ADV
futech-391	40	26	in	in	ADP
futech-391	40	27	the	the	DET
futech-391	40	28	case	case	NOUN
futech-391	40	29	of	of	ADP
futech-391	40	30	tubular	tubular	ADJ
futech-391	40	31	epithelial	epithelial	ADJ
futech-391	40	32	cells	cell	NOUN
futech-391	40	33	,	,	PUNCT
futech-391	40	34	where	where	SCONJ
futech-391	40	35	injury	injury	NOUN
futech-391	40	36	patterns	pattern	NOUN
futech-391	40	37	are	be	AUX
futech-391	40	38	heterogeneous	heterogeneous	ADJ
futech-391	40	39	within	within	ADP
futech-391	40	40	different	different	ADJ
futech-391	40	41	nephron	nephron	NOUN
futech-391	40	42	segments	segment	NOUN
futech-391	40	43	[	[	X
futech-391	40	44	13	13	NUM
futech-391	40	45	]	]	PUNCT
futech-391	40	46	.	.	PUNCT
futech-391	41	1	however	however	ADV
futech-391	41	2	,	,	PUNCT
futech-391	41	3	despite	despite	SCONJ
futech-391	41	4	these	these	DET
futech-391	41	5	technological	technological	ADJ
futech-391	41	6	advances	advance	NOUN
futech-391	41	7	,	,	PUNCT
futech-391	41	8	significant	significant	ADJ
futech-391	41	9	challenges	challenge	NOUN
futech-391	41	10	remain	remain	VERB
futech-391	41	11	in	in	ADP
futech-391	41	12	translating	translate	VERB
futech-391	41	13	omics	omic	NOUN
futech-391	41	14	-	-	PUNCT
futech-391	41	15	based	base	VERB
futech-391	41	16	discoveries	discovery	NOUN
futech-391	41	17	into	into	ADP
futech-391	41	18	clinically	clinically	ADV
futech-391	41	19	applicable	applicable	ADJ
futech-391	41	20	biomarkers	biomarker	NOUN
futech-391	41	21	.	.	PUNCT
futech-391	42	1	the	the	DET
futech-391	42	2	tissue	tissue	NOUN
futech-391	42	3	proteome	proteome	NOUN
futech-391	42	4	in	in	ADP
futech-391	42	5	the	the	DET
futech-391	42	6	multi	multi	ADJ
futech-391	42	7	-	-	ADJ
futech-391	42	8	omic	omic	ADJ
futech-391	42	9	landscape	landscape	NOUN
futech-391	42	10	of	of	ADP
futech-391	42	11	kidney	kidney	NOUN
futech-391	42	12	disease	disease	NOUN
futech-391	42	13	presents	present	VERB
futech-391	42	14	both	both	DET
futech-391	42	15	opportunities	opportunity	NOUN
futech-391	42	16	and	and	CCONJ
futech-391	42	17	challenges	challenge	NOUN
futech-391	42	18	for	for	ADP
futech-391	42	19	biomarker	biomarker	NOUN
futech-391	42	20	development	development	NOUN
futech-391	42	21	[	[	X
futech-391	42	22	14	14	NUM
futech-391	42	23	]	]	PUNCT
futech-391	42	24	.	.	PUNCT
futech-391	43	1	while	while	SCONJ
futech-391	43	2	integrated	integrated	ADJ
futech-391	43	3	multi	multi	ADJ
futech-391	43	4	-	-	ADJ
futech-391	43	5	omics	omics	ADJ
futech-391	43	6	approaches	approach	NOUN
futech-391	43	7	can	can	AUX
futech-391	43	8	improve	improve	VERB
futech-391	43	9	the	the	DET
futech-391	43	10	classification	classification	NOUN
futech-391	43	11	of	of	ADP
futech-391	43	12	chronic	chronic	ADJ
futech-391	43	13	kidney	kidney	NOUN
futech-391	43	14	disease	disease	NOUN
futech-391	43	15	,	,	PUNCT
futech-391	43	16	most	most	ADJ
futech-391	43	17	studies	study	NOUN
futech-391	43	18	have	have	AUX
futech-391	43	19	focused	focus	VERB
futech-391	43	20	on	on	ADP
futech-391	43	21	glomerular	glomerular	ADJ
futech-391	43	22	pathology	pathology	NOUN
futech-391	43	23	with	with	ADP
futech-391	43	24	limited	limited	ADJ
futech-391	43	25	attention	attention	NOUN
futech-391	43	26	to	to	ADP
futech-391	43	27	tubular	tubular	ADJ
futech-391	43	28	-	-	PUNCT
futech-391	43	29	specific	specific	ADJ
futech-391	43	30	markers	marker	NOUN
futech-391	43	31	[	[	X
futech-391	43	32	15	15	NUM
futech-391	43	33	]	]	PUNCT
futech-391	43	34	.	.	PUNCT
futech-391	44	1	comprehensive	comprehensive	ADJ
futech-391	44	2	multi	multi	ADJ
futech-391	44	3	-	-	ADJ
futech-391	44	4	omics	omics	ADJ
futech-391	44	5	analyses	analysis	NOUN
futech-391	44	6	have	have	AUX
futech-391	44	7	revealed	reveal	VERB
futech-391	44	8	potential	potential	ADJ
futech-391	44	9	new	new	ADJ
futech-391	44	10	mechanisms	mechanism	NOUN
futech-391	44	11	and	and	CCONJ
futech-391	44	12	drug	drug	NOUN
futech-391	44	13	targets	target	NOUN
futech-391	44	14	,	,	PUNCT
futech-391	44	15	yet	yet	CCONJ
futech-391	44	16	findings	finding	NOUN
futech-391	44	17	require	require	VERB
futech-391	44	18	validation	validation	NOUN
futech-391	44	19	in	in	ADP
futech-391	44	20	larger	large	ADJ
futech-391	44	21	,	,	PUNCT
futech-391	44	22	more	more	ADV
futech-391	44	23	diverse	diverse	ADJ
futech-391	44	24	patient	patient	ADJ
futech-391	44	25	populations	population	NOUN
futech-391	44	26	[	[	X
futech-391	44	27	16	16	NUM
futech-391	44	28	]	]	PUNCT
futech-391	44	29	.	.	PUNCT
futech-391	45	1	novel	novel	ADJ
futech-391	45	2	biomarkers	biomarker	NOUN
futech-391	45	3	have	have	AUX
futech-391	45	4	been	be	AUX
futech-391	45	5	identified	identify	VERB
futech-391	45	6	through	through	ADP
futech-391	45	7	omics	omic	NOUN
futech-391	45	8	approaches	approach	NOUN
futech-391	45	9	,	,	PUNCT
futech-391	45	10	but	but	CCONJ
futech-391	45	11	clinical	clinical	ADJ
futech-391	45	12	translation	translation	NOUN
futech-391	45	13	remains	remain	VERB
futech-391	45	14	challenging	challenge	VERB
futech-391	45	15	due	due	ADJ
futech-391	45	16	to	to	ADP
futech-391	45	17	issues	issue	NOUN
futech-391	45	18	of	of	ADP
futech-391	45	19	reproducibility	reproducibility	NOUN
futech-391	45	20	and	and	CCONJ
futech-391	45	21	standardization	standardization	NOUN
futech-391	45	22	across	across	ADP
futech-391	45	23	different	different	ADJ
futech-391	45	24	platforms	platform	NOUN
futech-391	46	1	[	[	X
futech-391	46	2	2	2	NUM
futech-391	46	3	]	]	PUNCT
futech-391	46	4	.	.	PUNCT
futech-391	47	1	machine	machine	NOUN
futech-391	47	2	learning	learn	VERB
futech-391	47	3	techniques	technique	NOUN
futech-391	47	4	have	have	AUX
futech-391	47	5	emerged	emerge	VERB
futech-391	47	6	as	as	ADP
futech-391	47	7	useful	useful	ADJ
futech-391	47	8	tools	tool	NOUN
futech-391	47	9	for	for	ADP
futech-391	47	10	investigating	investigate	VERB
futech-391	47	11	high	high	ADJ
futech-391	47	12	-	-	PUNCT
futech-391	47	13	dimensional	dimensional	ADJ
futech-391	47	14	omics	omic	NOUN
futech-391	47	15	data	datum	NOUN
futech-391	47	16	and	and	CCONJ
futech-391	47	17	understanding	understand	VERB
futech-391	47	18	biological	biological	ADJ
futech-391	47	19	implications	implication	NOUN
futech-391	47	20	[	[	X
futech-391	47	21	16	16	NUM
futech-391	47	22	]	]	PUNCT
futech-391	47	23	.	.	PUNCT
futech-391	48	1	computational	computational	ADJ
futech-391	48	2	methods	method	NOUN
futech-391	48	3	are	be	AUX
futech-391	48	4	well	well	ADV
futech-391	48	5	-	-	PUNCT
futech-391	48	6	suited	suited	ADJ
futech-391	48	7	to	to	PART
futech-391	48	8	identify	identify	VERB
futech-391	48	9	subtle	subtle	ADJ
futech-391	48	10	patterns	pattern	NOUN
futech-391	48	11	and	and	CCONJ
futech-391	48	12	interactions	interaction	NOUN
futech-391	48	13	in	in	ADP
futech-391	48	14	big	big	ADJ
futech-391	48	15	molecular	molecular	ADJ
futech-391	48	16	data	datum	NOUN
futech-391	48	17	that	that	PRON
futech-391	48	18	traditional	traditional	ADJ
futech-391	48	19	statistical	statistical	ADJ
futech-391	48	20	techniques	technique	NOUN
futech-391	48	21	would	would	AUX
futech-391	48	22	overlook	overlook	VERB
futech-391	48	23	[	[	X
futech-391	48	24	17	17	NUM
futech-391	48	25	]	]	PUNCT
futech-391	48	26	.	.	PUNCT
futech-391	49	1	machine	machine	NOUN
futech-391	49	2	learning	learning	NOUN
futech-391	49	3	-	-	PUNCT
futech-391	49	4	based	base	VERB
futech-391	49	5	methods	method	NOUN
futech-391	49	6	like	like	ADP
futech-391	49	7	random	random	ADJ
futech-391	49	8	forests	forest	NOUN
futech-391	49	9	,	,	PUNCT
futech-391	49	10	support	support	VERB
futech-391	49	11	vector	vector	NOUN
futech-391	49	12	machines	machine	NOUN
futech-391	49	13	,	,	PUNCT
futech-391	49	14	and	and	CCONJ
futech-391	49	15	deep	deep	ADJ
futech-391	49	16	learning	learning	NOUN
futech-391	49	17	networks	network	NOUN
futech-391	49	18	have	have	AUX
futech-391	49	19	been	be	AUX
futech-391	49	20	found	find	VERB
futech-391	49	21	effective	effective	ADJ
futech-391	49	22	for	for	ADP
futech-391	49	23	biomarker	biomarker	NOUN
futech-391	49	24	discovery	discovery	NOUN
futech-391	49	25	and	and	CCONJ
futech-391	49	26	disease	disease	NOUN
futech-391	49	27	classification	classification	NOUN
futech-391	49	28	tasks	task	NOUN
futech-391	49	29	[	[	X
futech-391	49	30	18	18	NUM
futech-391	49	31	]	]	PUNCT
futech-391	49	32	.	.	PUNCT
futech-391	50	1	artificial	artificial	ADJ
futech-391	50	2	intelligence	intelligence	NOUN
futech-391	50	3	applications	application	NOUN
futech-391	50	4	in	in	ADP
futech-391	50	5	dn	dn	PROPN
futech-391	50	6	research	research	NOUN
futech-391	50	7	have	have	AUX
futech-391	50	8	been	be	AUX
futech-391	50	9	helpful	helpful	ADJ
futech-391	50	10	in	in	ADP
futech-391	50	11	predicting	predict	VERB
futech-391	50	12	the	the	DET
futech-391	50	13	progression	progression	NOUN
futech-391	50	14	of	of	ADP
futech-391	50	15	disease	disease	NOUN
futech-391	50	16	,	,	PUNCT
futech-391	50	17	patient	patient	ADJ
futech-391	50	18	risk	risk	NOUN
futech-391	50	19	stratification	stratification	NOUN
futech-391	50	20	,	,	PUNCT
futech-391	50	21	and	and	CCONJ
futech-391	50	22	the	the	DET
futech-391	50	23	discovery	discovery	NOUN
futech-391	50	24	of	of	ADP
futech-391	50	25	therapeutic	therapeutic	ADJ
futech-391	50	26	targets	target	NOUN
futech-391	50	27	[	[	X
futech-391	50	28	19	19	NUM
futech-391	50	29	]	]	PUNCT
futech-391	50	30	.	.	PUNCT
futech-391	51	1	however	however	ADV
futech-391	51	2	,	,	PUNCT
futech-391	51	3	despite	despite	SCONJ
futech-391	51	4	these	these	DET
futech-391	51	5	technological	technological	ADJ
futech-391	51	6	advances	advance	NOUN
futech-391	51	7	,	,	PUNCT
futech-391	51	8	there	there	PRON
futech-391	51	9	are	be	VERB
futech-391	51	10	several	several	ADJ
futech-391	51	11	challenges	challenge	NOUN
futech-391	51	12	to	to	ADP
futech-391	51	13	the	the	DET
futech-391	51	14	conversion	conversion	NOUN
futech-391	51	15	of	of	ADP
futech-391	51	16	omics	omic	NOUN
futech-391	51	17	-	-	PUNCT
futech-391	51	18	based	base	VERB
futech-391	51	19	results	result	NOUN
futech-391	51	20	into	into	ADP
futech-391	51	21	clinically	clinically	ADV
futech-391	51	22	applicable	applicable	ADJ
futech-391	51	23	biomarkers	biomarker	NOUN
futech-391	51	24	[	[	X
futech-391	51	25	7	7	NUM
futech-391	51	26	]	]	PUNCT
futech-391	51	27	.	.	PUNCT
futech-391	52	1	these	these	PRON
futech-391	52	2	include	include	VERB
futech-391	52	3	data	datum	NOUN
futech-391	52	4	integration	integration	NOUN
futech-391	52	5	complexity	complexity	NOUN
futech-391	52	6	,	,	PUNCT
futech-391	52	7	model	model	NOUN
futech-391	52	8	interpretability	interpretability	NOUN
futech-391	52	9	,	,	PUNCT
futech-391	52	10	validation	validation	NOUN
futech-391	52	11	across	across	ADP
futech-391	52	12	the	the	DET
futech-391	52	13	heterogeneous	heterogeneous	ADJ
futech-391	52	14	population	population	NOUN
futech-391	52	15	,	,	PUNCT
futech-391	52	16	and	and	CCONJ
futech-391	52	17	standardization	standardization	NOUN
futech-391	52	18	of	of	ADP
futech-391	52	19	analytical	analytical	ADJ
futech-391	52	20	protocol	protocol	NOUN
futech-391	52	21	[	[	X
futech-391	52	22	20	20	NUM
futech-391	52	23	]	]	PUNCT
futech-391	52	24	.	.	PUNCT
futech-391	53	1	moreover	moreover	ADV
futech-391	53	2	,	,	PUNCT
futech-391	53	3	many	many	ADJ
futech-391	53	4	existing	exist	VERB
futech-391	53	5	studies	study	NOUN
futech-391	53	6	have	have	AUX
futech-391	53	7	focused	focus	VERB
futech-391	53	8	primarily	primarily	ADV
futech-391	53	9	on	on	ADP
futech-391	53	10	glomerular	glomerular	ADJ
futech-391	53	11	pathology	pathology	NOUN
futech-391	53	12	,	,	PUNCT
futech-391	53	13	with	with	ADP
futech-391	53	14	limited	limited	ADJ
futech-391	53	15	attention	attention	NOUN
futech-391	53	16	to	to	ADP
futech-391	53	17	tubular	tubular	ADJ
futech-391	53	18	-	-	PUNCT
futech-391	53	19	specific	specific	ADJ
futech-391	53	20	biomarkers	biomarker	NOUN
futech-391	53	21	despite	despite	SCONJ
futech-391	53	22	growing	grow	VERB
futech-391	53	23	evidence	evidence	NOUN
futech-391	53	24	of	of	ADP
futech-391	53	25	their	their	PRON
futech-391	53	26	clinical	clinical	ADJ
futech-391	53	27	relevance	relevance	NOUN
futech-391	53	28	[	[	X
futech-391	53	29	21	21	NUM
futech-391	53	30	]	]	PUNCT
futech-391	53	31	.	.	PUNCT
futech-391	54	1	the	the	DET
futech-391	54	2	application	application	NOUN
futech-391	54	3	of	of	ADP
futech-391	54	4	machine	machine	NOUN
futech-391	54	5	learning	learn	VERB
futech-391	54	6	techniques	technique	NOUN
futech-391	54	7	to	to	PART
futech-391	54	8	diabetic	diabetic	ADJ
futech-391	54	9	nephropathy	nephropathy	ADJ
futech-391	54	10	research	research	NOUN
futech-391	54	11	has	have	AUX
futech-391	54	12	shown	show	VERB
futech-391	54	13	promising	promising	ADJ
futech-391	54	14	but	but	CCONJ
futech-391	54	15	limited	limited	ADJ
futech-391	54	16	progress	progress	NOUN
futech-391	54	17	.	.	PUNCT
futech-391	55	1	comprehensive	comprehensive	ADJ
futech-391	55	2	bibliometric	bibliometric	ADJ
futech-391	55	3	analyses	analysis	NOUN
futech-391	55	4	reveal	reveal	VERB
futech-391	55	5	that	that	SCONJ
futech-391	55	6	while	while	SCONJ
futech-391	55	7	ai	ai	VERB
futech-391	55	8	techniques	technique	NOUN
futech-391	55	9	have	have	AUX
futech-391	55	10	advanced	advance	VERB
futech-391	55	11	significantly	significantly	ADV
futech-391	55	12	in	in	ADP
futech-391	55	13	diabetes	diabetes	NOUN
futech-391	55	14	research	research	NOUN
futech-391	55	15	,	,	PUNCT
futech-391	55	16	their	their	PRON
futech-391	55	17	application	application	NOUN
futech-391	55	18	to	to	ADP
futech-391	55	19	nephropathy	nephropathy	ADJ
futech-391	55	20	-	-	PUNCT
futech-391	55	21	specific	specific	ADJ
futech-391	55	22	biomarker	biomarker	NOUN
futech-391	55	23	discovery	discovery	NOUN
futech-391	55	24	remains	remain	VERB
futech-391	55	25	underdeveloped	underdeveloped	ADJ
futech-391	56	1	[	[	X
futech-391	56	2	5	5	NUM
futech-391	56	3	]	]	PUNCT
futech-391	56	4	.	.	PUNCT
futech-391	57	1	machine	machine	NOUN
futech-391	57	2	learning	learning	NOUN
futech-391	57	3	models	model	NOUN
futech-391	57	4	have	have	AUX
futech-391	57	5	demonstrated	demonstrate	VERB
futech-391	57	6	potential	potential	NOUN
futech-391	57	7	for	for	ADP
futech-391	57	8	predicting	predict	VERB
futech-391	57	9	diabetic	diabetic	ADJ
futech-391	57	10	kidney	kidney	NOUN
futech-391	57	11	disease	disease	NOUN
futech-391	57	12	risk	risk	NOUN
futech-391	57	13	,	,	PUNCT
futech-391	57	14	achieving	achieve	VERB
futech-391	57	15	reasonable	reasonable	ADJ
futech-391	57	16	accuracy	accuracy	NOUN
futech-391	57	17	but	but	CCONJ
futech-391	57	18	with	with	ADP
futech-391	57	19	limitations	limitation	NOUN
futech-391	57	20	in	in	ADP
futech-391	57	21	biomarker	biomarker	NOUN
futech-391	57	22	specificity	specificity	NOUN
futech-391	57	23	and	and	CCONJ
futech-391	57	24	population	population	NOUN
futech-391	57	25	generalizability	generalizability	NOUN
futech-391	57	26	[	[	X
futech-391	57	27	20	20	NUM
futech-391	57	28	]	]	PUNCT
futech-391	57	29	.	.	PUNCT
futech-391	58	1	literature	literature	NOUN
futech-391	58	2	reviews	review	NOUN
futech-391	58	3	of	of	ADP
futech-391	58	4	machine	machine	NOUN
futech-391	58	5	learning	learn	VERB
futech-391	58	6	techniques	technique	NOUN
futech-391	58	7	for	for	ADP
futech-391	58	8	diabetic	diabetic	ADJ
futech-391	58	9	nephropathy	nephropathy	ADJ
futech-391	58	10	risk	risk	NOUN
futech-391	58	11	prediction	prediction	NOUN
futech-391	58	12	identify	identify	VERB
futech-391	58	13	that	that	SCONJ
futech-391	58	14	most	most	ADJ
futech-391	58	15	existing	exist	VERB
futech-391	58	16	studies	study	NOUN
futech-391	58	17	employ	employ	VERB
futech-391	58	18	single	single	ADJ
futech-391	58	19	-	-	PUNCT
futech-391	58	20	platform	platform	NOUN
futech-391	58	21	data	datum	NOUN
futech-391	58	22	and	and	CCONJ
futech-391	58	23	lack	lack	VERB
futech-391	58	24	robust	robust	ADJ
futech-391	58	25	validation	validation	NOUN
futech-391	58	26	across	across	ADP
futech-391	58	27	diverse	diverse	ADJ
futech-391	58	28	populations	population	NOUN
futech-391	58	29	[	[	X
futech-391	58	30	21	21	NUM
futech-391	58	31	]	]	PUNCT
futech-391	58	32	.	.	PUNCT
futech-391	59	1	recent	recent	ADJ
futech-391	59	2	developments	development	NOUN
futech-391	59	3	in	in	ADP
futech-391	59	4	machine	machine	NOUN
futech-391	59	5	learning	learning	NOUN
futech-391	59	6	-	-	PUNCT
futech-391	59	7	based	base	VERB
futech-391	59	8	multi	multi	ADJ
futech-391	59	9	-	-	ADJ
futech-391	59	10	omics	omics	ADJ
futech-391	59	11	models	model	NOUN
futech-391	59	12	for	for	ADP
futech-391	59	13	diagnostic	diagnostic	ADJ
futech-391	59	14	classification	classification	NOUN
futech-391	59	15	represent	represent	VERB
futech-391	59	16	progress	progress	NOUN
futech-391	59	17	,	,	PUNCT
futech-391	59	18	yet	yet	CCONJ
futech-391	59	19	acknowledge	acknowledge	VERB
futech-391	59	20	the	the	DET
futech-391	59	21	need	need	NOUN
futech-391	59	22	for	for	ADP
futech-391	59	23	more	more	ADV
futech-391	59	24	sophisticated	sophisticated	ADJ
futech-391	59	25	ensemble	ensemble	ADJ
futech-391	59	26	methods	method	NOUN
futech-391	59	27	and	and	CCONJ
futech-391	59	28	tubular	tubular	ADJ
futech-391	59	29	-	-	PUNCT
futech-391	59	30	specific	specific	ADJ
futech-391	59	31	biomarker	biomarker	NOUN
futech-391	59	32	focus	focus	NOUN
futech-391	59	33	[	[	X
futech-391	59	34	3	3	NUM
futech-391	59	35	]	]	PUNCT
futech-391	59	36	.	.	PUNCT
futech-391	60	1	these	these	DET
futech-391	60	2	studies	study	NOUN
futech-391	60	3	collectively	collectively	ADV
futech-391	60	4	highlight	highlight	VERB
futech-391	60	5	the	the	DET
futech-391	60	6	potential	potential	NOUN
futech-391	60	7	of	of	ADP
futech-391	60	8	computational	computational	ADJ
futech-391	60	9	approaches	approach	NOUN
futech-391	60	10	while	while	SCONJ
futech-391	60	11	underscoring	underscore	VERB
futech-391	60	12	the	the	DET
futech-391	60	13	need	need	NOUN
futech-391	60	14	for	for	ADP
futech-391	60	15	more	more	ADV
futech-391	60	16	comprehensive	comprehensive	ADJ
futech-391	60	17	frameworks	framework	NOUN
futech-391	60	18	that	that	PRON
futech-391	60	19	can	can	AUX
futech-391	60	20	effectively	effectively	ADV
futech-391	60	21	integrate	integrate	VERB
futech-391	60	22	diverse	diverse	ADJ
futech-391	60	23	omics	omic	NOUN
futech-391	60	24	data	datum	NOUN
futech-391	60	25	types	type	NOUN
futech-391	60	26	.	.	PUNCT
futech-391	61	1	current	current	ADJ
futech-391	61	2	literature	literature	NOUN
futech-391	61	3	analysis	analysis	NOUN
futech-391	61	4	reveals	reveal	VERB
futech-391	61	5	three	three	NUM
futech-391	61	6	fundamental	fundamental	ADJ
futech-391	61	7	limitations	limitation	NOUN
futech-391	61	8	that	that	PRON
futech-391	61	9	hinder	hinder	VERB
futech-391	61	10	the	the	DET
futech-391	61	11	development	development	NOUN
futech-391	61	12	of	of	ADP
futech-391	61	13	clinically	clinically	ADV
futech-391	61	14	effective	effective	ADJ
futech-391	61	15	diabetic	diabetic	ADJ
futech-391	61	16	nephropathy	nephropathy	ADJ
futech-391	61	17	biomarkers	biomarker	NOUN
futech-391	61	18	.	.	PUNCT
futech-391	62	1	first	first	ADV
futech-391	62	2	,	,	PUNCT
futech-391	62	3	existing	exist	VERB
futech-391	62	4	biomarker	biomarker	NOUN
futech-391	62	5	studies	study	NOUN
futech-391	62	6	have	have	AUX
futech-391	62	7	predominantly	predominantly	ADV
futech-391	62	8	focused	focus	VERB
futech-391	62	9	on	on	ADP
futech-391	62	10	glomerular	glomerular	ADJ
futech-391	62	11	pathology	pathology	NOUN
futech-391	62	12	,	,	PUNCT
futech-391	62	13	with	with	ADP
futech-391	62	14	insufficient	insufficient	ADJ
futech-391	62	15	attention	attention	NOUN
futech-391	62	16	to	to	ADP
futech-391	62	17	tubular	tubular	ADJ
futech-391	62	18	epithelial	epithelial	ADJ
futech-391	62	19	cell	cell	NOUN
futech-391	62	20	-	-	PUNCT
futech-391	62	21	specific	specific	ADJ
futech-391	62	22	markers	marker	NOUN
futech-391	62	23	despite	despite	SCONJ
futech-391	62	24	growing	grow	VERB
futech-391	62	25	evidence	evidence	NOUN
futech-391	62	26	of	of	ADP
futech-391	62	27	their	their	PRON
futech-391	62	28	clinical	clinical	ADJ
futech-391	62	29	relevance	relevance	NOUN
futech-391	62	30	[	[	X
futech-391	62	31	22	22	NUM
futech-391	62	32	]	]	PUNCT
futech-391	62	33	.	.	PUNCT
futech-391	63	1	this	this	DET
futech-391	63	2	research	research	NOUN
futech-391	63	3	bias	bias	NOUN
futech-391	63	4	persists	persist	VERB
futech-391	63	5	even	even	ADV
futech-391	63	6	though	though	SCONJ
futech-391	63	7	recent	recent	ADJ
futech-391	63	8	evidence	evidence	NOUN
futech-391	63	9	suggests	suggest	VERB
futech-391	63	10	tubular	tubular	ADJ
futech-391	63	11	injury	injury	NOUN
futech-391	63	12	may	may	AUX
futech-391	63	13	occur	occur	VERB
futech-391	63	14	independently	independently	ADV
futech-391	63	15	of	of	ADP
futech-391	63	16	,	,	PUNCT
futech-391	63	17	and	and	CCONJ
futech-391	63	18	potentially	potentially	ADV
futech-391	63	19	precede	precede	VERB
futech-391	63	20	,	,	PUNCT
futech-391	63	21	glomerular	glomerular	ADJ
futech-391	63	22	damage	damage	NOUN
futech-391	63	23	.	.	PUNCT
futech-391	64	1	second	second	ADJ
futech-391	64	2	,	,	PUNCT
futech-391	64	3	most	most	ADV
futech-391	64	4	published	publish	VERB
futech-391	64	5	studies	study	NOUN
futech-391	64	6	have	have	AUX
futech-391	64	7	employed	employ	VERB
futech-391	64	8	single	single	ADJ
futech-391	64	9	-	-	PUNCT
futech-391	64	10	omics	omic	NOUN
futech-391	64	11	approaches	approach	NOUN
futech-391	64	12	that	that	PRON
futech-391	64	13	fail	fail	VERB
futech-391	64	14	to	to	PART
futech-391	64	15	capture	capture	VERB
futech-391	64	16	the	the	DET
futech-391	64	17	multidimensional	multidimensional	ADJ
futech-391	64	18	molecular	molecular	ADJ
futech-391	64	19	complexity	complexity	NOUN
futech-391	64	20	of	of	ADP
futech-391	64	21	diabetic	diabetic	ADJ
futech-391	64	22	kidney	kidney	NOUN
futech-391	64	23	disease	disease	NOUN
futech-391	65	1	[	[	X
futech-391	65	2	6	6	NUM
futech-391	65	3	]	]	PUNCT
futech-391	65	4	.	.	PUNCT
futech-391	66	1	this	this	DET
futech-391	66	2	limitation	limitation	NOUN
futech-391	66	3	results	result	VERB
futech-391	66	4	in	in	ADP
futech-391	66	5	biomarkers	biomarker	NOUN
futech-391	66	6	with	with	ADP
futech-391	66	7	restricted	restricted	ADJ
futech-391	66	8	clinical	clinical	ADJ
futech-391	66	9	utility	utility	NOUN
futech-391	66	10	and	and	CCONJ
futech-391	66	11	poor	poor	ADJ
futech-391	66	12	reproducibility	reproducibility	NOUN
futech-391	66	13	across	across	ADP
futech-391	66	14	different	different	ADJ
futech-391	66	15	patient	patient	ADJ
futech-391	66	16	populations	population	NOUN
futech-391	66	17	.	.	PUNCT
futech-391	67	1	third	third	ADJ
futech-391	67	2	,	,	PUNCT
futech-391	67	3	while	while	SCONJ
futech-391	67	4	machine	machine	NOUN
futech-391	67	5	learning	learning	NOUN
futech-391	67	6	applications	application	NOUN
futech-391	67	7	in	in	ADP
futech-391	67	8	diabetes	diabetes	NOUN
futech-391	67	9	research	research	NOUN
futech-391	67	10	have	have	AUX
futech-391	67	11	expanded	expand	VERB
futech-391	67	12	significantly	significantly	ADV
futech-391	67	13	,	,	PUNCT
futech-391	67	14	there	there	PRON
futech-391	67	15	remains	remain	VERB
futech-391	67	16	a	a	DET
futech-391	67	17	critical	critical	ADJ
futech-391	67	18	shortage	shortage	NOUN
futech-391	67	19	of	of	ADP
futech-391	67	20	robust	robust	ADJ
futech-391	67	21	computational	computational	ADJ
futech-391	67	22	frameworks	framework	NOUN
futech-391	67	23	specifically	specifically	ADV
futech-391	67	24	designed	design	VERB
futech-391	67	25	for	for	ADP
futech-391	67	26	multi	multi	ADJ
futech-391	67	27	-	-	ADJ
futech-391	67	28	omics	omics	ADJ
futech-391	67	29	integration	integration	NOUN
futech-391	67	30	in	in	ADP
futech-391	67	31	diabetic	diabetic	ADJ
futech-391	67	32	nephropathy	nephropathy	NOUN
futech-391	67	33	biomarker	biomarker	VERB
futech-391	67	34	discovery	discovery	NOUN
futech-391	68	1	[	[	X
futech-391	68	2	5	5	NUM
futech-391	68	3	]	]	PUNCT
futech-391	68	4	.	.	PUNCT
futech-391	69	1	this	this	DET
futech-391	69	2	study	study	NOUN
futech-391	69	3	addresses	address	VERB
futech-391	69	4	these	these	DET
futech-391	69	5	critical	critical	ADJ
futech-391	69	6	gaps	gap	NOUN
futech-391	69	7	by	by	ADP
futech-391	69	8	developing	develop	VERB
futech-391	69	9	a	a	DET
futech-391	69	10	comprehensive	comprehensive	ADJ
futech-391	69	11	machine	machine	NOUN
futech-391	69	12	learning	learn	VERB
futech-391	69	13	framework	framework	NOUN
futech-391	69	14	that	that	PRON
futech-391	69	15	integrates	integrate	VERB
futech-391	69	16	multi	multi	ADJ
futech-391	69	17	-	-	ADJ
futech-391	69	18	omics	omics	ADJ
futech-391	69	19	data	datum	NOUN
futech-391	69	20	specifically	specifically	ADV
futech-391	69	21	for	for	ADP
futech-391	69	22	tubular	tubular	ADJ
futech-391	69	23	epithelial	epithelial	ADJ
futech-391	69	24	cell	cell	NOUN
futech-391	69	25	biomarker	biomarker	NOUN
futech-391	69	26	identification	identification	NOUN
futech-391	69	27	.	.	PUNCT
futech-391	70	1	building	build	VERB
futech-391	70	2	upon	upon	SCONJ
futech-391	70	3	recent	recent	ADJ
futech-391	70	4	methodological	methodological	ADJ
futech-391	70	5	advances	advance	NOUN
futech-391	70	6	[	[	X
futech-391	70	7	21	21	NUM
futech-391	70	8	]	]	PUNCT
futech-391	70	9	,	,	PUNCT
futech-391	70	10	our	our	PRON
futech-391	70	11	approach	approach	NOUN
futech-391	70	12	represents	represent	VERB
futech-391	70	13	a	a	DET
futech-391	70	14	significant	significant	ADJ
futech-391	70	15	advancement	advancement	NOUN
futech-391	70	16	in	in	ADP
futech-391	70	17	both	both	PRON
futech-391	70	18	computational	computational	ADJ
futech-391	70	19	methodology	methodology	NOUN
futech-391	70	20	and	and	CCONJ
futech-391	70	21	biological	biological	ADJ
futech-391	70	22	focus	focus	NOUN
futech-391	70	23	.	.	PUNCT
futech-391	71	1	the	the	DET
futech-391	71	2	clinical	clinical	ADJ
futech-391	71	3	significance	significance	NOUN
futech-391	71	4	lies	lie	VERB
futech-391	71	5	in	in	ADP
futech-391	71	6	its	its	PRON
futech-391	71	7	potential	potential	NOUN
futech-391	71	8	to	to	PART
futech-391	71	9	overcome	overcome	VERB
futech-391	71	10	identified	identify	VERB
futech-391	71	11	diagnostic	diagnostic	ADJ
futech-391	71	12	limitations	limitation	NOUN
futech-391	71	13	[	[	X
futech-391	71	14	4	4	X
futech-391	71	15	]	]	PUNCT
futech-391	71	16	and	and	CCONJ
futech-391	71	17	provide	provide	VERB
futech-391	71	18	the	the	DET
futech-391	71	19	sensitive	sensitive	ADJ
futech-391	71	20	,	,	PUNCT
futech-391	71	21	earlydetection	earlydetection	NOUN
futech-391	71	22	biomarkers	biomarker	NOUN
futech-391	71	23	needed	need	VERB
futech-391	71	24	for	for	ADP
futech-391	71	25	improved	improved	ADJ
futech-391	71	26	patient	patient	ADJ
futech-391	71	27	management	management	NOUN
futech-391	71	28	.	.	PUNCT
futech-391	72	1	by	by	ADP
futech-391	72	2	focusing	focus	VERB
futech-391	72	3	on	on	ADP
futech-391	72	4	tubular	tubular	ADJ
futech-391	72	5	epithelial	epithelial	ADJ
futech-391	72	6	cell	cell	NOUN
futech-391	72	7	-	-	PUNCT
futech-391	72	8	specific	specific	ADJ
futech-391	72	9	signatures	signature	NOUN
futech-391	72	10	,	,	PUNCT
futech-391	72	11	this	this	DET
futech-391	72	12	study	study	NOUN
futech-391	72	13	addresses	address	VERB
futech-391	72	14	the	the	DET
futech-391	72	15	identified	identify	VERB
futech-391	72	16	research	research	NOUN
futech-391	72	17	gap	gap	NOUN
futech-391	73	1	[	[	X
futech-391	73	2	22	22	NUM
futech-391	73	3	]	]	PUNCT
futech-391	73	4	and	and	CCONJ
futech-391	73	5	could	could	AUX
futech-391	73	6	fundamentally	fundamentally	ADV
futech-391	73	7	shift	shift	VERB
futech-391	73	8	the	the	DET
futech-391	73	9	diagnostic	diagnostic	ADJ
futech-391	73	10	paradigm	paradigm	NOUN
futech-391	73	11	in	in	ADP
futech-391	73	12	diabetic	diabetic	ADJ
futech-391	73	13	nephropathy	nephropathy	ADJ
futech-391	73	14	management	management	NOUN
futech-391	73	15	.	.	PUNCT
futech-391	74	1	this	this	DET
futech-391	74	2	study	study	NOUN
futech-391	74	3	aims	aim	VERB
futech-391	74	4	to	to	PART
futech-391	74	5	:	:	PUNCT
futech-391	74	6	(	(	PUNCT
futech-391	74	7	1	1	X
futech-391	74	8	)	)	PUNCT
futech-391	74	9	develop	develop	VERB
futech-391	74	10	a	a	DET
futech-391	74	11	comprehensive	comprehensive	ADJ
futech-391	74	12	machine	machine	NOUN
futech-391	74	13	learning	learn	VERB
futech-391	74	14	framework	framework	NOUN
futech-391	74	15	for	for	ADP
futech-391	74	16	integrating	integrate	VERB
futech-391	74	17	multi	multi	ADJ
futech-391	74	18	-	-	ADJ
futech-391	74	19	omics	omics	ADJ
futech-391	74	20	data	datum	NOUN
futech-391	74	21	to	to	PART
futech-391	74	22	identify	identify	VERB
futech-391	74	23	tubular	tubular	ADJ
futech-391	74	24	epithelial	epithelial	ADJ
futech-391	74	25	cell	cell	NOUN
futech-391	74	26	-	-	PUNCT
futech-391	74	27	specific	specific	ADJ
futech-391	74	28	biomarkers	biomarker	NOUN
futech-391	74	29	in	in	ADP
futech-391	74	30	diabetic	diabetic	ADJ
futech-391	74	31	nephropathy	nephropathy	NOUN
futech-391	74	32	;	;	PUNCT
futech-391	74	33	(	(	PUNCT
futech-391	74	34	2	2	X
futech-391	74	35	)	)	PUNCT
futech-391	74	36	construct	construct	VERB
futech-391	74	37	an	an	DET
futech-391	74	38	ensemble	ensemble	ADJ
futech-391	74	39	learning	learning	NOUN
futech-391	74	40	model	model	NOUN
futech-391	74	41	to	to	PART
futech-391	74	42	improve	improve	VERB
futech-391	74	43	the	the	DET
futech-391	74	44	accuracy	accuracy	NOUN
futech-391	74	45	and	and	CCONJ
futech-391	74	46	sensitivity	sensitivity	NOUN
futech-391	74	47	of	of	ADP
futech-391	74	48	early	early	ADJ
futech-391	74	49	diabetic	diabetic	ADJ
futech-391	74	50	nephropathy	nephropathy	ADJ
futech-391	74	51	diagnosis	diagnosis	NOUN
futech-391	74	52	;	;	PUNCT
futech-391	74	53	(	(	PUNCT
futech-391	74	54	3	3	X
futech-391	74	55	)	)	PUNCT
futech-391	74	56	validate	validate	VERB
futech-391	74	57	the	the	DET
futech-391	74	58	clinical	clinical	ADJ
futech-391	74	59	utility	utility	NOUN
futech-391	74	60	and	and	CCONJ
futech-391	74	61	generalizability	generalizability	NOUN
futech-391	74	62	of	of	ADP
futech-391	74	63	identified	identify	VERB
futech-391	74	64	biomarkers	biomarker	NOUN
futech-391	74	65	across	across	ADP
futech-391	74	66	diverse	diverse	ADJ
futech-391	74	67	populations	population	NOUN
futech-391	74	68	;	;	PUNCT
futech-391	74	69	and	and	CCONJ
futech-391	74	70	(	(	PUNCT
futech-391	74	71	4	4	X
futech-391	74	72	)	)	PUNCT
futech-391	74	73	elucidate	elucidate	VERB
futech-391	74	74	the	the	DET
futech-391	74	75	molecular	molecular	ADJ
futech-391	74	76	mechanisms	mechanism	NOUN
futech-391	74	77	underlying	underlie	VERB
futech-391	74	78	tubular	tubular	ADJ
futech-391	74	79	epithelial	epithelial	ADJ
futech-391	74	80	cell	cell	NOUN
futech-391	74	81	injury	injury	NOUN
futech-391	74	82	in	in	ADP
futech-391	74	83	diabetic	diabetic	ADJ
futech-391	74	84	nephropathy	nephropathy	ADJ
futech-391	74	85	progression	progression	NOUN
futech-391	74	86	.	.	PUNCT
futech-391	75	1	w.	w.	PROPN
futech-391	75	2	li	li	PROPN
futech-391	75	3	&	&	CCONJ
futech-391	75	4	sp	sp	PROPN
futech-391	75	5	.	.	PROPN
futech-391	75	6	chandran	chandran	PROPN
futech-391	75	7	/future	/future	PUNCT
futech-391	75	8	technology	technology	PROPN
futech-391	75	9	august	august	PROPN
futech-391	75	10	2025|	2025|	NUM
futech-391	75	11	volume	volume	NOUN
futech-391	75	12	04	04	NUM
futech-391	76	1	|	|	NOUN
futech-391	76	2	issue	issue	NOUN
futech-391	76	3	03	03	NUM
futech-391	77	1	|	|	ADV
futech-391	77	2	pages	page	NOUN
futech-391	77	3	193	193	NUM
futech-391	77	4	-	-	SYM
futech-391	77	5	203	203	NUM
futech-391	77	6	195	195	NUM
futech-391	77	7	2	2	NUM
futech-391	77	8	.	.	PUNCT
futech-391	77	9	methods	method	NOUN
futech-391	77	10	2.1	2.1	NUM
futech-391	77	11	data	datum	NOUN
futech-391	77	12	acquisition	acquisition	NOUN
futech-391	77	13	and	and	CCONJ
futech-391	77	14	preprocessing	preprocesse	VERB
futech-391	77	15	the	the	DET
futech-391	77	16	integrative	integrative	ADJ
futech-391	77	17	multi	multi	ADJ
futech-391	77	18	-	-	ADJ
futech-391	77	19	omics	omics	ADJ
futech-391	77	20	approach	approach	NOUN
futech-391	77	21	implemented	implement	VERB
futech-391	77	22	in	in	ADP
futech-391	77	23	this	this	DET
futech-391	77	24	study	study	NOUN
futech-391	77	25	is	be	AUX
futech-391	77	26	presented	present	VERB
futech-391	77	27	in	in	ADP
futech-391	77	28	figure	figure	NOUN
futech-391	77	29	1	1	NUM
futech-391	77	30	.	.	PUNCT
futech-391	78	1	this	this	DET
futech-391	78	2	study	study	NOUN
futech-391	78	3	systematically	systematically	ADV
futech-391	78	4	retrieved	retrieve	VERB
futech-391	78	5	transcriptomic	transcriptomic	ADJ
futech-391	78	6	,	,	PUNCT
futech-391	78	7	proteomic	proteomic	NOUN
futech-391	78	8	,	,	PUNCT
futech-391	78	9	metabolomic	metabolomic	ADJ
futech-391	78	10	,	,	PUNCT
futech-391	78	11	and	and	CCONJ
futech-391	78	12	clinical	clinical	ADJ
futech-391	78	13	data	datum	NOUN
futech-391	78	14	from	from	ADP
futech-391	78	15	public	public	ADJ
futech-391	78	16	databases	database	NOUN
futech-391	78	17	like	like	ADP
futech-391	78	18	gene	gene	NOUN
futech-391	78	19	expression	expression	NOUN
futech-391	78	20	omnibus	omnibus	NOUN
futech-391	78	21	(	(	PUNCT
futech-391	78	22	geo	geo	PROPN
futech-391	78	23	)	)	PUNCT
futech-391	78	24	,	,	PUNCT
futech-391	78	25	the	the	DET
futech-391	78	26	cancer	cancer	NOUN
futech-391	78	27	genome	genome	NOUN
futech-391	78	28	atlas	atlas	PROPN
futech-391	78	29	(	(	PUNCT
futech-391	78	30	tcga	tcga	PROPN
futech-391	78	31	)	)	PUNCT
futech-391	78	32	,	,	PUNCT
futech-391	78	33	and	and	CCONJ
futech-391	78	34	proteomics	proteomic	NOUN
futech-391	78	35	identifications	identification	NOUN
futech-391	78	36	database	database	NOUN
futech-391	78	37	(	(	PUNCT
futech-391	78	38	pride	pride	NOUN
futech-391	78	39	)	)	PUNCT
futech-391	78	40	in	in	ADP
futech-391	78	41	a	a	DET
futech-391	78	42	systematic	systematic	ADJ
futech-391	78	43	manner	manner	NOUN
futech-391	78	44	.	.	PUNCT
futech-391	79	1	data	datum	NOUN
futech-391	79	2	selection	selection	NOUN
futech-391	79	3	focused	focus	VERB
futech-391	79	4	on	on	ADP
futech-391	79	5	specific	specific	ADJ
futech-391	79	6	datasets	dataset	NOUN
futech-391	79	7	pertaining	pertain	VERB
futech-391	79	8	to	to	ADP
futech-391	79	9	diabetic	diabetic	ADJ
futech-391	79	10	nephropathy	nephropathy	NOUN
futech-391	79	11	,	,	PUNCT
futech-391	79	12	emphasising	emphasise	VERB
futech-391	79	13	markers	marker	NOUN
futech-391	79	14	of	of	ADP
futech-391	79	15	tubular	tubular	ADJ
futech-391	79	16	epithelial	epithelial	ADJ
futech-391	79	17	cell	cell	NOUN
futech-391	79	18	dysfunction	dysfunction	NOUN
futech-391	79	19	.	.	PUNCT
futech-391	80	1	the	the	DET
futech-391	80	2	preprocessing	preprocessing	NOUN
futech-391	80	3	pipeline	pipeline	NOUN
futech-391	80	4	employed	employ	VERB
futech-391	80	5	stringent	stringent	ADJ
futech-391	80	6	quality	quality	NOUN
futech-391	80	7	control	control	NOUN
futech-391	80	8	processes	process	NOUN
futech-391	80	9	to	to	PART
futech-391	80	10	evaluate	evaluate	VERB
futech-391	80	11	the	the	DET
futech-391	80	12	integrity	integrity	NOUN
futech-391	80	13	,	,	PUNCT
futech-391	80	14	completeness	completeness	NOUN
futech-391	80	15	,	,	PUNCT
futech-391	80	16	and	and	CCONJ
futech-391	80	17	technical	technical	ADJ
futech-391	80	18	variability	variability	NOUN
futech-391	80	19	of	of	ADP
futech-391	80	20	the	the	DET
futech-391	80	21	data	datum	NOUN
futech-391	80	22	across	across	ADP
futech-391	80	23	different	different	ADJ
futech-391	80	24	experimental	experimental	ADJ
futech-391	80	25	platforms	platform	NOUN
futech-391	80	26	,	,	PUNCT
futech-391	80	27	batches	batch	NOUN
futech-391	80	28	,	,	PUNCT
futech-391	80	29	and	and	CCONJ
futech-391	80	30	conditions	condition	NOUN
futech-391	80	31	.	.	PUNCT
futech-391	81	1	normalisation	normalisation	NOUN
futech-391	81	2	was	be	AUX
futech-391	81	3	performed	perform	VERB
futech-391	81	4	at	at	ADP
futech-391	81	5	the	the	DET
futech-391	81	6	algorithmic	algorithmic	ADJ
futech-391	81	7	level	level	NOUN
futech-391	81	8	by	by	ADP
futech-391	81	9	employing	employ	VERB
futech-391	81	10	platform	platform	NOUN
futech-391	81	11	-	-	PUNCT
futech-391	81	12	specific	specific	ADJ
futech-391	81	13	methods	method	NOUN
futech-391	81	14	,	,	PUNCT
futech-391	81	15	such	such	ADJ
futech-391	81	16	as	as	ADP
futech-391	81	17	quantile	quantile	ADJ
futech-391	81	18	normalisation	normalisation	NOUN
futech-391	81	19	at	at	ADP
futech-391	81	20	the	the	DET
futech-391	81	21	microarray	microarray	NOUN
futech-391	81	22	level	level	NOUN
futech-391	81	23	,	,	PUNCT
futech-391	81	24	variance	variance	NOUN
futech-391	81	25	stabilising	stabilising	NOUN
futech-391	81	26	transformation	transformation	NOUN
futech-391	81	27	at	at	ADP
futech-391	81	28	the	the	DET
futech-391	81	29	rna	rna	NOUN
futech-391	81	30	-	-	PUNCT
futech-391	81	31	sequencing	sequence	VERB
futech-391	81	32	level	level	NOUN
futech-391	81	33	,	,	PUNCT
futech-391	81	34	and	and	CCONJ
futech-391	81	35	log2	log2	PROPN
futech-391	81	36	transformation	transformation	NOUN
futech-391	81	37	at	at	ADP
futech-391	81	38	the	the	DET
futech-391	81	39	proteomic	proteomic	ADJ
futech-391	81	40	level	level	NOUN
futech-391	81	41	.	.	PUNCT
futech-391	82	1	combat	combat	NOUN
futech-391	82	2	algorithm	algorithm	NOUN
futech-391	82	3	was	be	AUX
futech-391	82	4	used	use	VERB
futech-391	82	5	to	to	PART
futech-391	82	6	remove	remove	VERB
futech-391	82	7	batch	batch	NOUN
futech-391	82	8	effects	effect	NOUN
futech-391	82	9	for	for	ADP
futech-391	82	10	technical	technical	ADJ
futech-391	82	11	discrepancies	discrepancy	NOUN
futech-391	82	12	due	due	ADJ
futech-391	82	13	to	to	ADP
futech-391	82	14	different	different	ADJ
futech-391	82	15	experimental	experimental	ADJ
futech-391	82	16	conditions	condition	NOUN
futech-391	82	17	and	and	CCONJ
futech-391	82	18	data	datum	NOUN
futech-391	82	19	generation	generation	NOUN
futech-391	82	20	platforms	platform	NOUN
futech-391	82	21	.	.	PUNCT
futech-391	83	1	the	the	DET
futech-391	83	2	integrated	integrate	VERB
futech-391	83	3	dataset	dataset	NOUN
futech-391	83	4	was	be	AUX
futech-391	83	5	constructed	construct	VERB
futech-391	83	6	by	by	ADP
futech-391	83	7	identifying	identify	VERB
futech-391	83	8	samples	sample	NOUN
futech-391	83	9	with	with	ADP
futech-391	83	10	complete	complete	ADJ
futech-391	83	11	data	datum	NOUN
futech-391	83	12	across	across	ADP
futech-391	83	13	all	all	DET
futech-391	83	14	three	three	NUM
futech-391	83	15	omics	omic	NOUN
futech-391	83	16	platforms	platform	NOUN
futech-391	83	17	,	,	PUNCT
futech-391	83	18	resulting	result	VERB
futech-391	83	19	in	in	ADP
futech-391	83	20	178	178	NUM
futech-391	83	21	overlapping	overlap	VERB
futech-391	83	22	samples	sample	NOUN
futech-391	83	23	from	from	ADP
futech-391	83	24	the	the	DET
futech-391	83	25	original	original	ADJ
futech-391	83	26	datasets	dataset	NOUN
futech-391	83	27	(	(	PUNCT
futech-391	83	28	transcriptomic	transcriptomic	NOUN
futech-391	83	29	:	:	PUNCT
futech-391	83	30	245	245	NUM
futech-391	83	31	,	,	PUNCT
futech-391	83	32	proteomic	proteomic	NOUN
futech-391	83	33	:	:	PUNCT
futech-391	83	34	198	198	NUM
futech-391	83	35	,	,	PUNCT
futech-391	83	36	metabolomic	metabolomic	NOUN
futech-391	83	37	:	:	PUNCT
futech-391	83	38	167	167	NUM
futech-391	83	39	)	)	PUNCT
futech-391	83	40	.	.	PUNCT
futech-391	84	1	missing	miss	VERB
futech-391	84	2	values	value	NOUN
futech-391	84	3	below	below	ADP
futech-391	84	4	the	the	DET
futech-391	84	5	20	20	NUM
futech-391	84	6	%	%	NOUN
futech-391	84	7	threshold	threshold	NOUN
futech-391	84	8	were	be	AUX
futech-391	84	9	imputed	impute	VERB
futech-391	84	10	through	through	ADP
futech-391	84	11	the	the	DET
futech-391	84	12	k	k	NOUN
futech-391	84	13	-	-	PUNCT
futech-391	84	14	nearest	near	ADJ
futech-391	84	15	neighbours	neighbour	NOUN
futech-391	84	16	algorithm	algorithm	NOUN
futech-391	84	17	;	;	PUNCT
futech-391	84	18	samples	sample	NOUN
futech-391	84	19	exceeding	exceed	VERB
futech-391	84	20	this	this	DET
futech-391	84	21	threshold	threshold	NOUN
futech-391	84	22	(	(	PUNCT
futech-391	84	23	n=22	n=22	PROPN
futech-391	84	24	)	)	PUNCT
futech-391	84	25	were	be	AUX
futech-391	84	26	excluded	exclude	VERB
futech-391	84	27	from	from	ADP
futech-391	84	28	further	further	ADJ
futech-391	84	29	analyses	analysis	NOUN
futech-391	84	30	,	,	PUNCT
futech-391	84	31	yielding	yield	VERB
futech-391	84	32	the	the	DET
futech-391	84	33	final	final	ADJ
futech-391	84	34	integrated	integrated	ADJ
futech-391	84	35	dataset	dataset	NOUN
futech-391	84	36	of	of	ADP
futech-391	84	37	156	156	NUM
futech-391	84	38	samples	sample	NOUN
futech-391	84	39	with	with	ADP
futech-391	84	40	complete	complete	ADJ
futech-391	84	41	multi	multi	ADJ
futech-391	84	42	-	-	ADJ
futech-391	84	43	omics	omics	ADJ
futech-391	84	44	profiles	profile	NOUN
futech-391	84	45	.	.	PUNCT
futech-391	85	1	dimensionality	dimensionality	NOUN
futech-391	85	2	reduction	reduction	NOUN
futech-391	85	3	through	through	ADP
futech-391	85	4	principal	principal	ADJ
futech-391	85	5	component	component	NOUN
futech-391	85	6	analysis	analysis	NOUN
futech-391	85	7	,	,	PUNCT
futech-391	85	8	alongside	alongside	ADP
futech-391	85	9	other	other	ADJ
futech-391	85	10	methods	method	NOUN
futech-391	85	11	to	to	PART
futech-391	85	12	pinpoint	pinpoint	VERB
futech-391	85	13	the	the	DET
futech-391	85	14	most	most	ADV
futech-391	85	15	relevant	relevant	ADJ
futech-391	85	16	molecular	molecular	ADJ
futech-391	85	17	features	feature	NOUN
futech-391	85	18	,	,	PUNCT
futech-391	85	19	was	be	AUX
futech-391	85	20	performed	perform	VERB
futech-391	85	21	as	as	ADP
futech-391	85	22	part	part	NOUN
futech-391	85	23	of	of	ADP
futech-391	85	24	feature	feature	NOUN
futech-391	85	25	engineering	engineering	NOUN
futech-391	85	26	.	.	PUNCT
futech-391	86	1	prior	prior	ADV
futech-391	86	2	to	to	ADP
futech-391	86	3	developing	develop	VERB
futech-391	86	4	the	the	DET
futech-391	86	5	machine	machine	NOUN
futech-391	86	6	learning	learning	NOUN
futech-391	86	7	models	model	NOUN
futech-391	86	8	,	,	PUNCT
futech-391	86	9	as	as	ADP
futech-391	86	10	the	the	DET
futech-391	86	11	final	final	ADJ
futech-391	86	12	step	step	NOUN
futech-391	86	13	,	,	PUNCT
futech-391	86	14	the	the	DET
futech-391	86	15	merged	merge	VERB
futech-391	86	16	multi	multi	ADJ
futech-391	86	17	-	-	ADJ
futech-391	86	18	omics	omics	ADJ
futech-391	86	19	dataset	dataset	VERB
futech-391	86	20	underwent	underwent	NOUN
futech-391	86	21	quality	quality	NOUN
futech-391	86	22	control	control	NOUN
futech-391	86	23	assessments	assessment	NOUN
futech-391	86	24	to	to	PART
futech-391	86	25	check	check	VERB
futech-391	86	26	for	for	ADP
futech-391	86	27	compatibility	compatibility	NOUN
futech-391	86	28	and	and	CCONJ
futech-391	86	29	coherence	coherence	NOUN
futech-391	86	30	across	across	ADP
futech-391	86	31	differing	differ	VERB
futech-391	86	32	data	datum	NOUN
futech-391	86	33	types	type	NOUN
futech-391	86	34	,	,	PUNCT
futech-391	86	35	providing	provide	VERB
futech-391	86	36	a	a	DET
futech-391	86	37	strong	strong	ADJ
futech-391	86	38	basis	basis	NOUN
futech-391	86	39	for	for	ADP
futech-391	86	40	later	later	ADJ
futech-391	86	41	analyses	analysis	NOUN
futech-391	86	42	to	to	PART
futech-391	86	43	discover	discover	VERB
futech-391	86	44	biomarkers	biomarker	NOUN
futech-391	86	45	.	.	PUNCT
futech-391	87	1	figure	figure	NOUN
futech-391	87	2	1	1	NUM
futech-391	87	3	.	.	PUNCT
futech-391	88	1	multi	multi	ADJ
futech-391	88	2	-	-	ADJ
futech-391	88	3	omics	omics	ADJ
futech-391	88	4	machine	machine	NOUN
futech-391	88	5	learning	learn	VERB
futech-391	88	6	framework	framework	NOUN
futech-391	88	7	and	and	CCONJ
futech-391	88	8	analytical	analytical	ADJ
futech-391	88	9	pipeline	pipeline	NOUN
futech-391	88	10	2.2	2.2	NUM
futech-391	88	11	machine	machine	NOUN
futech-391	88	12	learning	learning	NOUN
futech-391	88	13	model	model	NOUN
futech-391	88	14	construction	construction	NOUN
futech-391	88	15	this	this	DET
futech-391	88	16	study	study	NOUN
futech-391	88	17	implemented	implement	VERB
futech-391	88	18	a	a	DET
futech-391	88	19	complete	complete	ADJ
futech-391	88	20	ensemble	ensemble	ADJ
futech-391	88	21	learning	learning	NOUN
futech-391	88	22	technique	technique	NOUN
futech-391	88	23	,	,	PUNCT
futech-391	88	24	which	which	PRON
futech-391	88	25	included	include	VERB
futech-391	88	26	three	three	NUM
futech-391	88	27	distinct	distinct	ADJ
futech-391	88	28	machine	machine	NOUN
futech-391	88	29	learning	learn	VERB
futech-391	88	30	algorithms	algorithm	NOUN
futech-391	88	31	for	for	ADP
futech-391	88	32	better	well	ADJ
futech-391	88	33	predictive	predictive	ADJ
futech-391	88	34	accuracy	accuracy	NOUN
futech-391	88	35	and	and	CCONJ
futech-391	88	36	reliable	reliable	ADJ
futech-391	88	37	identification	identification	NOUN
futech-391	88	38	of	of	ADP
futech-391	88	39	biomarkers	biomarker	NOUN
futech-391	88	40	[	[	X
futech-391	88	41	23	23	NUM
futech-391	88	42	]	]	PUNCT
futech-391	88	43	.	.	PUNCT
futech-391	89	1	the	the	DET
futech-391	89	2	feature	feature	NOUN
futech-391	89	3	engineering	engineering	NOUN
futech-391	89	4	method	method	NOUN
futech-391	89	5	applied	apply	VERB
futech-391	89	6	recursive	recursive	ADJ
futech-391	89	7	feature	feature	NOUN
futech-391	89	8	elimination	elimination	NOUN
futech-391	89	9	in	in	ADP
futech-391	89	10	combination	combination	NOUN
futech-391	89	11	with	with	ADP
futech-391	89	12	correlation	correlation	NOUN
futech-391	89	13	-	-	PUNCT
futech-391	89	14	based	base	VERB
futech-391	89	15	filtering	filtering	NOUN
futech-391	89	16	methods	method	NOUN
futech-391	89	17	to	to	PART
futech-391	89	18	determine	determine	VERB
futech-391	89	19	the	the	DET
futech-391	89	20	optimal	optimal	ADJ
futech-391	89	21	molecular	molecular	ADJ
futech-391	89	22	signatures	signature	NOUN
futech-391	89	23	from	from	ADP
futech-391	89	24	the	the	DET
futech-391	89	25	integrated	integrate	VERB
futech-391	89	26	multiomics	multiomics	NOUN
futech-391	89	27	dataset	dataset	NOUN
futech-391	89	28	.	.	PUNCT
futech-391	90	1	the	the	DET
futech-391	90	2	random	random	ADJ
futech-391	90	3	forest	forest	NOUN
futech-391	90	4	algorithm	algorithm	NOUN
futech-391	90	5	was	be	AUX
futech-391	90	6	implemented	implement	VERB
futech-391	90	7	with	with	ADP
futech-391	90	8	the	the	DET
futech-391	90	9	objective	objective	ADJ
futech-391	90	10	function	function	NOUN
futech-391	90	11	optimized	optimize	VERB
futech-391	90	12	through	through	ADP
futech-391	90	13	bootstrap	bootstrap	NOUN
futech-391	90	14	aggregation	aggregation	NOUN
futech-391	90	15	:	:	PUNCT
futech-391	90	16	�	�	PROPN
futech-391	90	17	̂	̂	SYM
futech-391	90	18	�	�	NOUN
futech-391	90	19	=	=	SYM
futech-391	90	20	1	1	NUM
futech-391	90	21	𝐵	𝐵	NOUN
futech-391	90	22	∑	∑	PUNCT
futech-391	90	23	𝑇𝑏	𝑇𝑏	PROPN
futech-391	90	24	𝐵	𝐵	NOUN
futech-391	90	25	b=1	b=1	X
futech-391	90	26	(	(	PUNCT
futech-391	90	27	𝑥	𝑥	NOUN
futech-391	90	28	)	)	PUNCT
futech-391	90	29	(	(	PUNCT
futech-391	90	30	1	1	X
futech-391	90	31	)	)	PUNCT
futech-391	90	32	where	where	SCONJ
futech-391	90	33	(	(	PUNCT
futech-391	90	34	)	)	PUNCT
futech-391	90	35	bt	bt	NOUN
futech-391	90	36	x	x	PUNCT
futech-391	90	37	represents	represent	VERB
futech-391	90	38	individual	individual	ADJ
futech-391	90	39	decision	decision	NOUN
futech-391	90	40	trees	tree	NOUN
futech-391	90	41	and	and	CCONJ
futech-391	90	42	b	b	NOUN
futech-391	90	43	denotes	denote	NOUN
futech-391	90	44	the	the	DET
futech-391	90	45	number	number	NOUN
futech-391	90	46	of	of	ADP
futech-391	90	47	bootstrap	bootstrap	NOUN
futech-391	90	48	samples	sample	NOUN
futech-391	90	49	.	.	PUNCT
futech-391	91	1	support	support	NOUN
futech-391	91	2	vector	vector	NOUN
futech-391	91	3	machine	machine	NOUN
futech-391	91	4	classification	classification	NOUN
futech-391	91	5	employed	employ	VERB
futech-391	91	6	the	the	DET
futech-391	91	7	radial	radial	ADJ
futech-391	91	8	basis	basis	NOUN
futech-391	91	9	function	function	NOUN
futech-391	91	10	kernel	kernel	NOUN
futech-391	91	11	with	with	ADP
futech-391	91	12	the	the	DET
futech-391	91	13	optimization	optimization	NOUN
futech-391	91	14	problem	problem	NOUN
futech-391	91	15	formulated	formulate	VERB
futech-391	91	16	as	as	ADP
futech-391	91	17	:	:	PUNCT
futech-391	91	18	𝑚𝑖𝑛	𝑚𝑖𝑛	NOUN
futech-391	91	19	𝑤,𝑏,𝜉	𝑤,𝑏,𝜉	NUM
futech-391	91	20	1	1	NUM
futech-391	91	21	2	2	NUM
futech-391	91	22	||𝑤||2	||𝑤||2	PROPN
futech-391	91	23	+	+	NUM
futech-391	91	24	𝐶∑	𝐶∑	ADJ
futech-391	91	25	𝜉𝑖	𝜉𝑖	ADP
futech-391	91	26	𝑛	𝑛	DET
futech-391	91	27	𝑖=1	𝑖=1	PROPN
futech-391	91	28	(	(	PUNCT
futech-391	91	29	2	2	NUM
futech-391	91	30	)	)	PUNCT
futech-391	91	31	subject	subject	NOUN
futech-391	91	32	to	to	ADP
futech-391	91	33	constraints	constraint	NOUN
futech-391	91	34			NOUN
futech-391	91	35	+	+	VERB
futech-391	91	36			NUM
futech-391	91	37	−	−	PROPN
futech-391	91	38	(	(	PUNCT
futech-391	91	39	(	(	PUNCT
futech-391	91	40	)	)	PUNCT
futech-391	91	41	)	)	PUNCT
futech-391	92	1	1	1	NUM
futech-391	92	2	t	t	X
futech-391	92	3	i	i	PRON
futech-391	93	1	i	i	PRON
futech-391	93	2	iy	iy	INTJ
futech-391	94	1	w	w	NOUN
futech-391	94	2	x	x	SYM
futech-391	94	3	b	b	PROPN
futech-391	94	4	and	and	CCONJ
futech-391	94	5			VERB
futech-391	94	6	0i	0i	X
futech-391	94	7	the	the	DET
futech-391	94	8	xgboost	xgboost	PROPN
futech-391	94	9	model	model	PROPN
futech-391	94	10	used	use	VERB
futech-391	94	11	gradient	gradient	NOUN
futech-391	94	12	boosting	boost	VERB
futech-391	94	13	with	with	ADP
futech-391	94	14	the	the	DET
futech-391	94	15	loss	loss	NOUN
futech-391	94	16	function	function	NOUN
futech-391	94	17	consisting	consist	VERB
futech-391	94	18	of	of	ADP
futech-391	94	19	bias	bias	NOUN
futech-391	94	20	and	and	CCONJ
futech-391	94	21	variance	variance	NOUN
futech-391	94	22	components	component	NOUN
futech-391	94	23	that	that	PRON
futech-391	94	24	were	be	AUX
futech-391	94	25	combined	combine	VERB
futech-391	94	26	to	to	PART
futech-391	94	27	prevent	prevent	VERB
futech-391	94	28	overfitting	overfitte	VERB
futech-391	94	29	[	[	X
futech-391	94	30	24	24	NUM
futech-391	94	31	]	]	PUNCT
futech-391	94	32	.	.	PUNCT
futech-391	95	1	hyperparameter	hyperparameter	NOUN
futech-391	95	2	optimization	optimization	NOUN
futech-391	95	3	used	use	VERB
futech-391	95	4	bayesian	bayesian	NOUN
futech-391	95	5	optimization	optimization	NOUN
futech-391	95	6	with	with	ADP
futech-391	95	7	gaussian	gaussian	ADJ
futech-391	95	8	process	process	NOUN
futech-391	95	9	priors	prior	NOUN
futech-391	95	10	and	and	CCONJ
futech-391	95	11	expected	expect	VERB
futech-391	95	12	improvement	improvement	NOUN
futech-391	95	13	acquisition	acquisition	NOUN
futech-391	95	14	function	function	NOUN
futech-391	95	15	,	,	PUNCT
futech-391	95	16	targeting	target	VERB
futech-391	95	17	cross	cross	ADJ
futech-391	95	18	-	-	ADJ
futech-391	95	19	validation	validation	ADJ
futech-391	95	20	auc	auc	NOUN
futech-391	95	21	maximization	maximization	NOUN
futech-391	95	22	.	.	PUNCT
futech-391	96	1	search	search	NOUN
futech-391	96	2	spaces	space	NOUN
futech-391	96	3	included	include	VERB
futech-391	96	4	:	:	PUNCT
futech-391	96	5	random	random	ADJ
futech-391	96	6	forest	forest	NOUN
futech-391	96	7	(	(	PUNCT
futech-391	96	8	n_estimators	n_estimator	NOUN
futech-391	96	9	:	:	PUNCT
futech-391	96	10	50500	50500	NUM
futech-391	96	11	,	,	PUNCT
futech-391	96	12	max_depth	max_depth	X
futech-391	96	13	:	:	PUNCT
futech-391	96	14	3	3	NUM
futech-391	96	15	-	-	SYM
futech-391	96	16	20	20	NUM
futech-391	96	17	)	)	PUNCT
futech-391	96	18	,	,	PUNCT
futech-391	96	19	svm	svm	PROPN
futech-391	96	20	(	(	PUNCT
futech-391	96	21	c	c	NOUN
futech-391	96	22	:	:	PUNCT
futech-391	96	23	0.1	0.1	NUM
futech-391	96	24	-	-	SYM
futech-391	96	25	100	100	NUM
futech-391	96	26	,	,	PUNCT
futech-391	96	27	gamma	gamma	NOUN
futech-391	96	28	:	:	PUNCT
futech-391	96	29	0.001	0.001	NUM
futech-391	96	30	-	-	SYM
futech-391	96	31	1	1	NUM
futech-391	96	32	)	)	PUNCT
futech-391	96	33	,	,	PUNCT
futech-391	96	34	and	and	CCONJ
futech-391	96	35	xgboost	xgboost	ADV
futech-391	96	36	(	(	PUNCT
futech-391	96	37	learning_rate	learning_rate	NUM
futech-391	96	38	:	:	PUNCT
futech-391	96	39	0.01	0.01	NUM
futech-391	96	40	-	-	SYM
futech-391	96	41	0.3	0.3	NUM
futech-391	96	42	,	,	PUNCT
futech-391	96	43	max_depth	max_depth	X
futech-391	96	44	:	:	PUNCT
futech-391	96	45	3	3	NUM
futech-391	96	46	-	-	SYM
futech-391	96	47	10	10	NUM
futech-391	96	48	,	,	PUNCT
futech-391	96	49	subsample	subsample	NOUN
futech-391	96	50	:	:	PUNCT
futech-391	96	51	0.6	0.6	NUM
futech-391	96	52	-	-	SYM
futech-391	96	53	1.0	1.0	NUM
futech-391	96	54	)	)	PUNCT
futech-391	96	55	,	,	PUNCT
futech-391	96	56	with	with	ADP
futech-391	96	57	100	100	NUM
futech-391	96	58	iterations	iteration	NOUN
futech-391	96	59	for	for	ADP
futech-391	96	60	convergence	convergence	NOUN
futech-391	96	61	.	.	PUNCT
futech-391	97	1	the	the	DET
futech-391	97	2	ensemble	ensemble	ADJ
futech-391	97	3	model	model	NOUN
futech-391	97	4	combined	combine	VERB
futech-391	97	5	predictions	prediction	NOUN
futech-391	97	6	of	of	ADP
futech-391	97	7	all	all	DET
futech-391	97	8	three	three	NUM
futech-391	97	9	models	model	NOUN
futech-391	97	10	using	use	VERB
futech-391	97	11	weighted	weighted	ADJ
futech-391	97	12	voting	voting	NOUN
futech-391	97	13	,	,	PUNCT
futech-391	97	14	where	where	SCONJ
futech-391	97	15	weights	weight	NOUN
futech-391	97	16	were	be	AUX
futech-391	97	17	determined	determine	VERB
futech-391	97	18	based	base	VERB
futech-391	97	19	on	on	ADP
futech-391	97	20	individual	individual	ADJ
futech-391	97	21	model	model	NOUN
futech-391	97	22	performance	performance	NOUN
futech-391	97	23	during	during	ADP
futech-391	97	24	crossvalidation	crossvalidation	NOUN
futech-391	97	25	.	.	PUNCT
futech-391	98	1	specifically	specifically	ADV
futech-391	98	2	,	,	PUNCT
futech-391	98	3	weights	weight	NOUN
futech-391	98	4	were	be	AUX
futech-391	98	5	calculated	calculate	VERB
futech-391	98	6	using	use	VERB
futech-391	98	7	the	the	DET
futech-391	98	8	formula	formula	NOUN
futech-391	98	9	:	:	PUNCT
futech-391	98	10	𝑤𝑖	𝑤𝑖	ADP
futech-391	98	11	=	=	PUNCT
futech-391	98	12	𝐴𝑈𝐶𝑖	𝐴𝑈𝐶𝑖	PROPN
futech-391	98	13	∑	∑	PROPN
futech-391	98	14	𝐴3	𝐴3	PROPN
futech-391	98	15	𝑗=1	𝑗=1	PROPN
futech-391	98	16	𝑈𝐶𝑗	𝑈𝐶𝑗	NOUN
futech-391	98	17	(	(	PUNCT
futech-391	98	18	3	3	NUM
futech-391	98	19	)	)	PUNCT
futech-391	98	20	where	where	SCONJ
futech-391	98	21	auci	auci	PROPN
futech-391	98	22	represents	represent	VERB
futech-391	98	23	the	the	DET
futech-391	98	24	cross	cross	ADJ
futech-391	98	25	-	-	ADJ
futech-391	98	26	validation	validation	ADJ
futech-391	98	27	auc	auc	NOUN
futech-391	98	28	score	score	NOUN
futech-391	98	29	of	of	ADP
futech-391	98	30	model	model	NOUN
futech-391	98	31	i	i	PRON
futech-391	98	32	.	.	PUNCT
futech-391	99	1	this	this	DET
futech-391	99	2	approach	approach	NOUN
futech-391	99	3	resulted	result	VERB
futech-391	99	4	in	in	ADP
futech-391	99	5	weight	weight	NOUN
futech-391	99	6	assignments	assignment	NOUN
futech-391	99	7	of	of	ADP
futech-391	99	8	0.42	0.42	NUM
futech-391	99	9	for	for	ADP
futech-391	99	10	xgboost	xgboost	NUM
futech-391	99	11	,	,	PUNCT
futech-391	99	12	0.35	0.35	NUM
futech-391	99	13	for	for	ADP
futech-391	99	14	random	random	ADJ
futech-391	99	15	forest	forest	NOUN
futech-391	99	16	,	,	PUNCT
futech-391	99	17	and	and	CCONJ
futech-391	99	18	0.23	0.23	NUM
futech-391	99	19	for	for	ADP
futech-391	99	20	support	support	NOUN
futech-391	99	21	vector	vector	NOUN
futech-391	99	22	machine	machine	NOUN
futech-391	99	23	,	,	PUNCT
futech-391	99	24	reflecting	reflect	VERB
futech-391	99	25	their	their	PRON
futech-391	99	26	relative	relative	ADJ
futech-391	99	27	discriminative	discriminative	NOUN
futech-391	99	28	capabilities	capability	NOUN
futech-391	99	29	.	.	PUNCT
futech-391	100	1	model	model	NOUN
futech-391	100	2	training	training	NOUN
futech-391	100	3	incorporated	incorporate	VERB
futech-391	100	4	stratified	stratified	ADJ
futech-391	100	5	sampling	sample	VERB
futech-391	100	6	to	to	PART
futech-391	100	7	maintain	maintain	VERB
futech-391	100	8	class	class	NOUN
futech-391	100	9	balance	balance	NOUN
futech-391	100	10	,	,	PUNCT
futech-391	100	11	early	early	ADJ
futech-391	100	12	stopping	stopping	NOUN
futech-391	100	13	methods	method	NOUN
futech-391	100	14	,	,	PUNCT
futech-391	100	15	and	and	CCONJ
futech-391	100	16	enhanced	enhanced	ADJ
futech-391	100	17	regularization	regularization	NOUN
futech-391	100	18	(	(	PUNCT
futech-391	100	19	min_samples_split=8	min_samples_split=8	NOUN
futech-391	100	20	for	for	ADP
futech-391	100	21	random	random	ADJ
futech-391	100	22	forest	forest	NOUN
futech-391	100	23	,	,	PUNCT
futech-391	100	24	subsample=0.85	subsample=0.85	VERB
futech-391	100	25	for	for	ADP
futech-391	100	26	xgboost	xgboost	PROPN
futech-391	100	27	)	)	PUNCT
futech-391	100	28	to	to	PART
futech-391	100	29	prevent	prevent	VERB
futech-391	100	30	overfitting	overfitting	NOUN
futech-391	100	31	given	give	VERB
futech-391	100	32	the	the	DET
futech-391	100	33	limited	limited	ADJ
futech-391	100	34	sample	sample	NOUN
futech-391	100	35	size	size	NOUN
futech-391	100	36	.	.	PUNCT
futech-391	101	1	performance	performance	NOUN
futech-391	101	2	measures	measure	NOUN
futech-391	101	3	comprised	comprise	VERB
futech-391	101	4	accuracy	accuracy	NOUN
futech-391	101	5	,	,	PUNCT
futech-391	101	6	sensitivity	sensitivity	NOUN
futech-391	101	7	,	,	PUNCT
futech-391	101	8	specificity	specificity	NOUN
futech-391	101	9	,	,	PUNCT
futech-391	101	10	and	and	CCONJ
futech-391	101	11	area	area	NOUN
futech-391	101	12	under	under	ADP
futech-391	101	13	the	the	DET
futech-391	101	14	receiver	receiver	NOUN
futech-391	101	15	operating	operate	VERB
futech-391	101	16	characteristic	characteristic	ADJ
futech-391	101	17	curve	curve	NOUN
futech-391	101	18	to	to	PART
futech-391	101	19	ensure	ensure	VERB
futech-391	101	20	a	a	DET
futech-391	101	21	comprehensive	comprehensive	ADJ
futech-391	101	22	assessment	assessment	NOUN
futech-391	101	23	of	of	ADP
futech-391	101	24	predictive	predictive	ADJ
futech-391	101	25	capacity	capacity	NOUN
futech-391	101	26	across	across	ADP
futech-391	101	27	different	different	ADJ
futech-391	101	28	classification	classification	NOUN
futech-391	101	29	thresholds	threshold	NOUN
futech-391	101	30	and	and	CCONJ
futech-391	101	31	clinical	clinical	ADJ
futech-391	101	32	scenarios	scenario	NOUN
futech-391	101	33	.	.	PUNCT
futech-391	102	1	2.3	2.3	NUM
futech-391	102	2	biomarker	biomarker	NOUN
futech-391	102	3	screening	screening	NOUN
futech-391	102	4	and	and	CCONJ
futech-391	102	5	validation	validation	NOUN
futech-391	102	6	the	the	DET
futech-391	102	7	investigation	investigation	NOUN
futech-391	102	8	employed	employ	VERB
futech-391	102	9	an	an	DET
futech-391	102	10	algorithmic	algorithmic	ADJ
futech-391	102	11	approach	approach	NOUN
futech-391	102	12	to	to	PART
futech-391	102	13	search	search	VERB
futech-391	102	14	for	for	ADP
futech-391	102	15	several	several	ADJ
futech-391	102	16	tubular	tubular	ADJ
futech-391	102	17	epithelial	epithelial	ADJ
futech-391	102	18	cell	cell	NOUN
futech-391	102	19	-	-	PUNCT
futech-391	102	20	specific	specific	ADJ
futech-391	102	21	molecular	molecular	ADJ
futech-391	102	22	signature	signature	NOUN
futech-391	102	23	biomarkers	biomarker	NOUN
futech-391	102	24	associated	associate	VERB
futech-391	102	25	with	with	ADP
futech-391	102	26	the	the	DET
futech-391	102	27	outputs	output	NOUN
futech-391	102	28	of	of	ADP
futech-391	102	29	a	a	DET
futech-391	102	30	machine	machine	NOUN
futech-391	102	31	learning	learn	VERB
futech-391	102	32	model	model	NOUN
futech-391	102	33	.	.	PUNCT
futech-391	103	1	candidate	candidate	NOUN
futech-391	103	2	biomarkers	biomarker	NOUN
futech-391	103	3	were	be	AUX
futech-391	103	4	ranked	rank	VERB
futech-391	103	5	based	base	VERB
futech-391	103	6	on	on	ADP
futech-391	103	7	ensemble	ensemble	ADJ
futech-391	103	8	methods	method	NOUN
futech-391	103	9	importance	importance	NOUN
futech-391	103	10	feature	feature	NOUN
futech-391	103	11	scores	score	NOUN
futech-391	103	12	,	,	PUNCT
futech-391	103	13	focusing	focus	VERB
futech-391	103	14	on	on	ADP
futech-391	103	15	molecules	molecule	NOUN
futech-391	103	16	exhibiting	exhibit	VERB
futech-391	103	17	coherent	coherent	ADJ
futech-391	103	18	expressions	expression	NOUN
futech-391	103	19	across	across	ADP
futech-391	103	20	various	various	ADJ
futech-391	103	21	omics	omic	NOUN
futech-391	103	22	platforms	platform	NOUN
futech-391	103	23	.	.	PUNCT
futech-391	104	1	the	the	DET
futech-391	104	2	tubular	tubular	ADJ
futech-391	104	3	cell	cell	NOUN
futech-391	104	4	specificity	specificity	NOUN
futech-391	104	5	was	be	AUX
futech-391	104	6	addressed	address	VERB
futech-391	104	7	by	by	ADP
futech-391	104	8	performing	perform	VERB
futech-391	104	9	extensive	extensive	ADJ
futech-391	104	10	bibliometric	bibliometric	ADJ
futech-391	104	11	analysis	analysis	NOUN
futech-391	104	12	as	as	ADV
futech-391	104	13	well	well	ADV
futech-391	104	14	as	as	ADP
futech-391	104	15	pathway	pathway	NOUN
futech-391	104	16	enrichment	enrichment	NOUN
futech-391	104	17	analysis	analysis	NOUN
futech-391	104	18	for	for	ADP
futech-391	104	19	known	known	ADJ
futech-391	104	20	markers	marker	NOUN
futech-391	104	21	of	of	ADP
futech-391	104	22	tubular	tubular	ADJ
futech-391	104	23	dysfunction	dysfunction	NOUN
futech-391	104	24	such	such	ADJ
futech-391	104	25	as	as	ADP
futech-391	104	26	kidney	kidney	NOUN
futech-391	104	27	injury	injury	PROPN
futech-391	104	28	molecule-1	molecule-1	PROPN
futech-391	104	29	,	,	PUNCT
futech-391	104	30	neutrophil	neutrophil	ADJ
futech-391	104	31	gelatinase	gelatinase	NOUN
futech-391	104	32	-	-	PUNCT
futech-391	104	33	associated	associate	VERB
futech-391	104	34	lipocalin	lipocalin	NOUN
futech-391	104	35	,	,	PUNCT
futech-391	104	36	liver	liver	NOUN
futech-391	104	37	-	-	PUNCT
futech-391	104	38	type	type	NOUN
futech-391	104	39	fatty	fatty	NOUN
futech-391	104	40	acid	acid	NOUN
futech-391	104	41	binding	bind	VERB
futech-391	104	42	protein	protein	NOUN
futech-391	104	43	[	[	X
futech-391	104	44	25	25	NUM
futech-391	104	45	]	]	PUNCT
futech-391	104	46	.	.	PUNCT
futech-391	105	1	the	the	DET
futech-391	105	2	screening	screening	NOUN
futech-391	105	3	included	include	VERB
futech-391	105	4	testing	test	VERB
futech-391	105	5	statistical	statistical	ADJ
futech-391	105	6	significance	significance	NOUN
futech-391	105	7	and	and	CCONJ
futech-391	105	8	making	make	VERB
futech-391	105	9	a	a	DET
futech-391	105	10	correction	correction	NOUN
futech-391	105	11	for	for	ADP
futech-391	105	12	false	false	ADJ
futech-391	105	13	w.	w.	PROPN
futech-391	105	14	li	li	PROPN
futech-391	105	15	&	&	CCONJ
futech-391	105	16	sp	sp	PROPN
futech-391	105	17	.	.	PROPN
futech-391	105	18	chandran	chandran	PROPN
futech-391	105	19	/future	/future	PUNCT
futech-391	105	20	technology	technology	PROPN
futech-391	105	21	august	august	PROPN
futech-391	105	22	2025|	2025|	NUM
futech-391	106	1	volume	volume	NOUN
futech-391	106	2	04	04	NUM
futech-391	107	1	|	|	NOUN
futech-391	107	2	issue	issue	NOUN
futech-391	107	3	03	03	NUM
futech-391	108	1	|	|	ADV
futech-391	108	2	pages	page	NOUN
futech-391	108	3	193	193	NUM
futech-391	108	4	-	-	SYM
futech-391	108	5	203	203	NUM
futech-391	108	6	196	196	NUM
futech-391	108	7	discovery	discovery	NOUN
futech-391	108	8	rate	rate	NOUN
futech-391	108	9	to	to	PART
futech-391	108	10	control	control	VERB
futech-391	108	11	for	for	ADP
futech-391	108	12	multiple	multiple	ADJ
futech-391	108	13	comparisons	comparison	NOUN
futech-391	108	14	,	,	PUNCT
futech-391	108	15	thus	thus	ADV
futech-391	108	16	ascertaining	ascertain	VERB
futech-391	108	17	robust	robust	ADJ
futech-391	108	18	identification	identification	NOUN
futech-391	108	19	of	of	ADP
futech-391	108	20	biomedically	biomedically	ADV
futech-391	108	21	relevant	relevant	ADJ
futech-391	108	22	markers	marker	NOUN
futech-391	108	23	.	.	PUNCT
futech-391	109	1	the	the	DET
futech-391	109	2	validation	validation	NOUN
futech-391	109	3	of	of	ADP
futech-391	109	4	the	the	DET
futech-391	109	5	models	model	NOUN
futech-391	109	6	was	be	AUX
futech-391	109	7	carried	carry	VERB
futech-391	109	8	out	out	ADP
futech-391	109	9	using	use	VERB
futech-391	109	10	a	a	DET
futech-391	109	11	stringent	stringent	ADJ
futech-391	109	12	two	two	NUM
futech-391	109	13	-	-	PUNCT
futech-391	109	14	tiered	tiere	VERB
futech-391	109	15	approach	approach	NOUN
futech-391	109	16	involving	involve	VERB
futech-391	109	17	internal	internal	ADJ
futech-391	109	18	crossvalidation	crossvalidation	NOUN
futech-391	109	19	and	and	CCONJ
futech-391	109	20	external	external	ADJ
futech-391	109	21	validation	validation	NOUN
futech-391	109	22	on	on	ADP
futech-391	109	23	independent	independent	ADJ
futech-391	109	24	patient	patient	ADJ
futech-391	109	25	cohorts	cohort	NOUN
futech-391	109	26	.	.	PUNCT
futech-391	110	1	for	for	ADP
futech-391	110	2	internal	internal	ADJ
futech-391	110	3	validation	validation	NOUN
futech-391	110	4	,	,	PUNCT
futech-391	110	5	a	a	DET
futech-391	110	6	stratified	stratified	ADJ
futech-391	110	7	k	k	ADJ
futech-391	110	8	-	-	ADJ
futech-391	110	9	fold	fold	ADJ
futech-391	110	10	crossvalidation	crossvalidation	NOUN
futech-391	110	11	was	be	AUX
futech-391	110	12	conducted	conduct	VERB
futech-391	110	13	to	to	PART
futech-391	110	14	evaluate	evaluate	VERB
futech-391	110	15	model	model	NOUN
futech-391	110	16	retention	retention	NOUN
futech-391	110	17	and	and	CCONJ
futech-391	110	18	applicability	applicability	NOUN
futech-391	110	19	testing	testing	NOUN
futech-391	110	20	among	among	ADP
futech-391	110	21	various	various	ADJ
futech-391	110	22	patient	patient	ADJ
futech-391	110	23	group	group	NOUN
futech-391	110	24	subtypes	subtype	NOUN
futech-391	110	25	[	[	X
futech-391	110	26	26	26	NUM
futech-391	110	27	]	]	PUNCT
futech-391	110	28	.	.	PUNCT
futech-391	111	1	external	external	ADJ
futech-391	111	2	validation	validation	NOUN
futech-391	111	3	was	be	AUX
futech-391	111	4	conducted	conduct	VERB
futech-391	111	5	using	use	VERB
futech-391	111	6	geographically	geographically	ADV
futech-391	111	7	distinct	distinct	ADJ
futech-391	111	8	patient	patient	ADJ
futech-391	111	9	populations	population	NOUN
futech-391	111	10	to	to	PART
futech-391	111	11	evaluate	evaluate	VERB
futech-391	111	12	model	model	NOUN
futech-391	111	13	performance	performance	NOUN
futech-391	111	14	in	in	ADP
futech-391	111	15	real	real	ADJ
futech-391	111	16	-	-	PUNCT
futech-391	111	17	world	world	NOUN
futech-391	111	18	clinical	clinical	ADJ
futech-391	111	19	settings	setting	NOUN
futech-391	111	20	.	.	PUNCT
futech-391	112	1	the	the	DET
futech-391	112	2	validation	validation	NOUN
futech-391	112	3	framework	framework	NOUN
futech-391	112	4	assessed	assess	VERB
futech-391	112	5	discriminative	discriminative	NOUN
futech-391	112	6	performance	performance	NOUN
futech-391	112	7	using	use	VERB
futech-391	112	8	area	area	NOUN
futech-391	112	9	under	under	ADP
futech-391	112	10	the	the	DET
futech-391	112	11	curve	curve	NOUN
futech-391	112	12	metrics	metric	NOUN
futech-391	112	13	and	and	CCONJ
futech-391	112	14	clinical	clinical	ADJ
futech-391	112	15	utility	utility	NOUN
futech-391	112	16	through	through	ADP
futech-391	112	17	decision	decision	NOUN
futech-391	112	18	curve	curve	NOUN
futech-391	112	19	analysis	analysis	NOUN
futech-391	112	20	.	.	PUNCT
futech-391	113	1	independent	independent	ADJ
futech-391	113	2	cohort	cohort	NOUN
futech-391	113	3	validation	validation	NOUN
futech-391	113	4	specifically	specifically	ADV
futech-391	113	5	targeted	target	VERB
futech-391	113	6	patients	patient	NOUN
futech-391	113	7	with	with	ADP
futech-391	113	8	early	early	ADJ
futech-391	113	9	-	-	PUNCT
futech-391	113	10	stage	stage	NOUN
futech-391	113	11	diabetic	diabetic	ADJ
futech-391	113	12	nephropathy	nephropathy	NOUN
futech-391	113	13	to	to	PART
futech-391	113	14	evaluate	evaluate	VERB
futech-391	113	15	the	the	DET
futech-391	113	16	biomarkers	biomarker	NOUN
futech-391	113	17	'	'	PART
futech-391	113	18	predictive	predictive	ADJ
futech-391	113	19	capability	capability	NOUN
futech-391	113	20	for	for	ADP
futech-391	113	21	disease	disease	NOUN
futech-391	113	22	progression	progression	NOUN
futech-391	113	23	and	and	CCONJ
futech-391	113	24	therapeutic	therapeutic	ADJ
futech-391	113	25	response	response	NOUN
futech-391	113	26	monitoring	monitoring	NOUN
futech-391	113	27	.	.	PUNCT
futech-391	114	1	3	3	X
futech-391	114	2	.	.	NOUN
futech-391	114	3	results	result	VERB
futech-391	114	4	3.1	3.1	NUM
futech-391	114	5	multi	multi	ADJ
futech-391	114	6	-	-	ADJ
futech-391	114	7	omics	omics	ADJ
futech-391	114	8	data	data	NOUN
futech-391	114	9	integration	integration	NOUN
futech-391	114	10	quality	quality	NOUN
futech-391	114	11	assessment	assessment	NOUN
futech-391	114	12	the	the	DET
futech-391	114	13	multi	multi	ADJ
futech-391	114	14	-	-	ADJ
futech-391	114	15	omics	omics	ADJ
futech-391	114	16	data	data	NOUN
futech-391	114	17	integration	integration	NOUN
futech-391	114	18	process	process	NOUN
futech-391	114	19	demonstrated	demonstrate	VERB
futech-391	114	20	substantial	substantial	ADJ
futech-391	114	21	improvements	improvement	NOUN
futech-391	114	22	in	in	ADP
futech-391	114	23	data	datum	NOUN
futech-391	114	24	quality	quality	NOUN
futech-391	114	25	and	and	CCONJ
futech-391	114	26	consistency	consistency	NOUN
futech-391	114	27	across	across	ADP
futech-391	114	28	all	all	DET
futech-391	114	29	molecular	molecular	ADJ
futech-391	114	30	platforms	platform	NOUN
futech-391	114	31	,	,	PUNCT
futech-391	114	32	as	as	SCONJ
futech-391	114	33	shown	show	VERB
futech-391	114	34	in	in	ADP
futech-391	114	35	table	table	NOUN
futech-391	114	36	1	1	NUM
futech-391	114	37	.	.	PUNCT
futech-391	115	1	the	the	DET
futech-391	115	2	study	study	NOUN
futech-391	115	3	successfully	successfully	ADV
futech-391	115	4	acquired	acquire	VERB
futech-391	115	5	transcriptomic	transcriptomic	ADJ
futech-391	115	6	data	datum	NOUN
futech-391	115	7	from	from	ADP
futech-391	115	8	245	245	NUM
futech-391	115	9	samples	sample	NOUN
futech-391	115	10	with	with	ADP
futech-391	115	11	18,632	18,632	NUM
futech-391	115	12	features	feature	NOUN
futech-391	115	13	,	,	PUNCT
futech-391	115	14	proteomic	proteomic	ADJ
futech-391	115	15	data	datum	NOUN
futech-391	115	16	from	from	ADP
futech-391	115	17	198	198	NUM
futech-391	115	18	samples	sample	NOUN
futech-391	115	19	with	with	ADP
futech-391	115	20	4,521	4,521	NUM
futech-391	115	21	features	feature	NOUN
futech-391	115	22	,	,	PUNCT
futech-391	115	23	and	and	CCONJ
futech-391	115	24	metabolomic	metabolomic	ADJ
futech-391	115	25	data	datum	NOUN
futech-391	115	26	from	from	ADP
futech-391	115	27	167	167	NUM
futech-391	115	28	samples	sample	NOUN
futech-391	115	29	with	with	ADP
futech-391	115	30	812	812	NUM
futech-391	115	31	features	feature	NOUN
futech-391	115	32	.	.	PUNCT
futech-391	116	1	batch	batch	NOUN
futech-391	116	2	effect	effect	NOUN
futech-391	116	3	correction	correction	NOUN
futech-391	116	4	using	use	VERB
futech-391	116	5	the	the	DET
futech-391	116	6	combat	combat	NOUN
futech-391	116	7	algorithm	algorithm	NOUN
futech-391	116	8	resulted	result	VERB
futech-391	116	9	in	in	ADP
futech-391	116	10	remarkable	remarkable	ADJ
futech-391	116	11	reductions	reduction	NOUN
futech-391	116	12	in	in	ADP
futech-391	116	13	the	the	DET
futech-391	116	14	coefficient	coefficient	NOUN
futech-391	116	15	of	of	ADP
futech-391	116	16	variation	variation	NOUN
futech-391	116	17	across	across	ADP
futech-391	116	18	all	all	DET
futech-391	116	19	data	datum	NOUN
futech-391	116	20	types	type	NOUN
futech-391	116	21	,	,	PUNCT
futech-391	116	22	with	with	ADP
futech-391	116	23	transcriptomic	transcriptomic	ADJ
futech-391	116	24	data	datum	NOUN
futech-391	116	25	showing	show	VERB
futech-391	116	26	the	the	DET
futech-391	116	27	most	most	ADV
futech-391	116	28	substantial	substantial	ADJ
futech-391	116	29	improvement	improvement	NOUN
futech-391	116	30	from	from	ADP
futech-391	116	31	15.2	15.2	NUM
futech-391	116	32	%	%	NOUN
futech-391	116	33	to	to	ADP
futech-391	116	34	3.4	3.4	NUM
futech-391	116	35	%	%	NOUN
futech-391	116	36	.	.	PUNCT
futech-391	117	1	proteomic	proteomic	NOUN
futech-391	117	2	and	and	CCONJ
futech-391	117	3	metabolomic	metabolomic	ADJ
futech-391	117	4	datasets	dataset	NOUN
futech-391	117	5	exhibited	exhibit	VERB
futech-391	117	6	similar	similar	ADJ
futech-391	117	7	enhancements	enhancement	NOUN
futech-391	117	8	,	,	PUNCT
futech-391	117	9	with	with	ADP
futech-391	117	10	cv	cv	PROPN
futech-391	117	11	values	value	NOUN
futech-391	117	12	decreasing	decrease	VERB
futech-391	117	13	from	from	ADP
futech-391	117	14	12.7	12.7	NUM
futech-391	117	15	%	%	NOUN
futech-391	117	16	to	to	PART
futech-391	117	17	2.9	2.9	NUM
futech-391	117	18	%	%	NOUN
futech-391	117	19	and	and	CCONJ
futech-391	117	20	from	from	ADP
futech-391	117	21	18.9	18.9	NUM
futech-391	117	22	%	%	NOUN
futech-391	117	23	to	to	ADP
futech-391	117	24	4.1	4.1	NUM
futech-391	117	25	%	%	NOUN
futech-391	117	26	,	,	PUNCT
futech-391	117	27	respectively	respectively	ADV
futech-391	117	28	.	.	PUNCT
futech-391	118	1	data	datum	NOUN
futech-391	118	2	completeness	completeness	NOUN
futech-391	118	3	remained	remain	VERB
futech-391	118	4	consistently	consistently	ADV
futech-391	118	5	high	high	ADJ
futech-391	118	6	across	across	ADP
futech-391	118	7	all	all	DET
futech-391	118	8	platforms	platform	NOUN
futech-391	118	9	,	,	PUNCT
futech-391	118	10	ranging	range	VERB
futech-391	118	11	from	from	ADP
futech-391	118	12	92.7	92.7	NUM
futech-391	118	13	%	%	NOUN
futech-391	118	14	to	to	ADP
futech-391	118	15	96.8	96.8	NUM
futech-391	118	16	%	%	NOUN
futech-391	118	17	,	,	PUNCT
futech-391	118	18	indicating	indicate	VERB
futech-391	118	19	successful	successful	ADJ
futech-391	118	20	quality	quality	NOUN
futech-391	118	21	control	control	NOUN
futech-391	118	22	and	and	CCONJ
futech-391	118	23	preprocessing	preprocessing	NOUN
futech-391	118	24	procedures	procedure	NOUN
futech-391	118	25	.	.	PUNCT
futech-391	119	1	the	the	DET
futech-391	119	2	integrated	integrate	VERB
futech-391	119	3	multi	multi	ADJ
futech-391	119	4	-	-	ADJ
futech-391	119	5	omics	omics	ADJ
futech-391	119	6	dataset	dataset	NOUN
futech-391	119	7	contained	contain	VERB
futech-391	119	8	156	156	NUM
futech-391	119	9	samples	sample	NOUN
futech-391	119	10	with	with	ADP
futech-391	119	11	23,965	23,965	NUM
futech-391	119	12	molecular	molecular	ADJ
futech-391	119	13	features	feature	NOUN
futech-391	119	14	and	and	CCONJ
futech-391	119	15	achieved	achieve	VERB
futech-391	119	16	95.1	95.1	NUM
futech-391	119	17	%	%	NOUN
futech-391	119	18	data	datum	NOUN
futech-391	119	19	completeness	completeness	NOUN
futech-391	119	20	.	.	PUNCT
futech-391	120	1	the	the	DET
futech-391	120	2	harmonisation	harmonisation	NOUN
futech-391	120	3	of	of	ADP
futech-391	120	4	technical	technical	ADJ
futech-391	120	5	variability	variability	NOUN
futech-391	120	6	across	across	ADP
futech-391	120	7	different	different	ADJ
futech-391	120	8	omics	omic	NOUN
futech-391	120	9	platforms	platform	NOUN
futech-391	120	10	was	be	AUX
futech-391	120	11	successful	successful	ADJ
futech-391	120	12	,	,	PUNCT
futech-391	120	13	given	give	VERB
futech-391	120	14	the	the	DET
futech-391	120	15	reduced	reduced	ADJ
futech-391	120	16	coefficient	coefficient	NOUN
futech-391	120	17	of	of	ADP
futech-391	120	18	variation	variation	NOUN
futech-391	120	19	(	(	PUNCT
futech-391	120	20	3.2	3.2	NUM
futech-391	120	21	%	%	NOUN
futech-391	120	22	)	)	PUNCT
futech-391	120	23	for	for	ADP
futech-391	120	24	the	the	DET
futech-391	120	25	integrated	integrate	VERB
futech-391	120	26	dataset	dataset	NOUN
futech-391	120	27	.	.	PUNCT
futech-391	121	1	table	table	NOUN
futech-391	121	2	1	1	NUM
futech-391	121	3	.	.	PUNCT
futech-391	122	1	multi	multi	ADJ
futech-391	122	2	-	-	ADJ
futech-391	122	3	omics	omics	ADJ
futech-391	122	4	data	data	NOUN
futech-391	122	5	integration	integration	NOUN
futech-391	122	6	quality	quality	NOUN
futech-391	122	7	assessment	assessment	NOUN
futech-391	122	8	data	datum	NOUN
futech-391	122	9	type	type	NOUN
futech-391	122	10	sample	sample	NOUN
futech-391	122	11	size	size	NOUN
futech-391	122	12	features	feature	VERB
futech-391	122	13	cv	cv	PROPN
futech-391	122	14	before	before	ADP
futech-391	122	15	correction	correction	NOUN
futech-391	122	16	(	(	PUNCT
futech-391	122	17	%	%	INTJ
futech-391	122	18	)	)	PUNCT
futech-391	122	19	cv	cv	PROPN
futech-391	122	20	after	after	ADP
futech-391	122	21	correction	correction	NOUN
futech-391	122	22	(	(	PUNCT
futech-391	122	23	%	%	INTJ
futech-391	122	24	)	)	PUNCT
futech-391	122	25	data	datum	NOUN
futech-391	122	26	completen	completen	VERB
futech-391	122	27	ess	ess	PROPN
futech-391	122	28	(	(	PUNCT
futech-391	122	29	%	%	INTJ
futech-391	122	30	)	)	PUNCT
futech-391	122	31	transcriptomics	transcriptomic	NOUN
futech-391	122	32	245	245	NUM
futech-391	122	33	18,632	18,632	NUM
futech-391	122	34	15.2	15.2	NUM
futech-391	122	35	3.4	3.4	NUM
futech-391	122	36	96.8	96.8	NUM
futech-391	122	37	proteomics	proteomic	NOUN
futech-391	122	38	198	198	NUM
futech-391	122	39	4,521	4,521	NUM
futech-391	122	40	12.7	12.7	NUM
futech-391	122	41	2.9	2.9	NUM
futech-391	122	42	94.3	94.3	NUM
futech-391	122	43	metabolomics	metabolomic	NOUN
futech-391	122	44	167	167	NUM
futech-391	122	45	812	812	NUM
futech-391	122	46	18.9	18.9	NUM
futech-391	122	47	4.1	4.1	NUM
futech-391	122	48	92.7	92.7	NUM
futech-391	122	49	integrated	integrate	VERB
futech-391	122	50	dataset	dataset	NOUN
futech-391	122	51	156	156	NUM
futech-391	122	52	23,965	23,965	NUM
futech-391	122	53	14.8	14.8	NUM
futech-391	122	54	3.2	3.2	NUM
futech-391	122	55	95.1	95.1	NUM
futech-391	122	56	note	note	NOUN
futech-391	122	57	:	:	PUNCT
futech-391	122	58	cv	cv	ADJ
futech-391	122	59	:	:	PUNCT
futech-391	122	60	coefficient	coefficient	NOUN
futech-391	122	61	of	of	ADP
futech-391	122	62	variation	variation	NOUN
futech-391	122	63	.	.	PUNCT
futech-391	123	1	data	datum	NOUN
futech-391	123	2	completeness	completeness	NOUN
futech-391	123	3	represents	represent	VERB
futech-391	123	4	the	the	DET
futech-391	123	5	percentage	percentage	NOUN
futech-391	123	6	of	of	ADP
futech-391	123	7	non	non	ADJ
futech-391	123	8	-	-	ADJ
futech-391	123	9	missing	missing	ADJ
futech-391	123	10	values	value	NOUN
futech-391	123	11	after	after	ADP
futech-391	123	12	quality	quality	NOUN
futech-391	123	13	control	control	NOUN
futech-391	123	14	and	and	CCONJ
futech-391	123	15	preprocessing	preprocessing	NOUN
futech-391	123	16	.	.	PUNCT
futech-391	124	1	batch	batch	NOUN
futech-391	124	2	effect	effect	NOUN
futech-391	124	3	correction	correction	NOUN
futech-391	124	4	was	be	AUX
futech-391	124	5	performed	perform	VERB
futech-391	124	6	using	use	VERB
futech-391	124	7	the	the	DET
futech-391	124	8	combat	combat	NOUN
futech-391	124	9	algorithm	algorithm	NOUN
futech-391	124	10	,	,	PUNCT
futech-391	124	11	resulting	result	VERB
futech-391	124	12	in	in	ADP
futech-391	124	13	a	a	DET
futech-391	124	14	significant	significant	ADJ
futech-391	124	15	reduction	reduction	NOUN
futech-391	124	16	of	of	ADP
futech-391	124	17	technical	technical	ADJ
futech-391	124	18	variability	variability	NOUN
futech-391	124	19	across	across	ADP
futech-391	124	20	all	all	DET
futech-391	124	21	omics	omic	NOUN
futech-391	124	22	platforms	platform	NOUN
futech-391	124	23	.	.	PUNCT
futech-391	125	1	the	the	DET
futech-391	125	2	integrated	integrate	VERB
futech-391	125	3	dataset	dataset	NOUN
futech-391	125	4	represents	represent	VERB
futech-391	125	5	samples	sample	NOUN
futech-391	125	6	with	with	ADP
futech-391	125	7	complete	complete	ADJ
futech-391	125	8	multi	multi	ADJ
futech-391	125	9	-	-	ADJ
futech-391	125	10	omics	omics	ADJ
futech-391	125	11	profiles	profile	NOUN
futech-391	125	12	available	available	ADJ
futech-391	125	13	for	for	ADP
futech-391	125	14	downstream	downstream	ADJ
futech-391	125	15	machine	machine	NOUN
futech-391	125	16	learning	learn	VERB
futech-391	125	17	analysis	analysis	NOUN
futech-391	125	18	.	.	PUNCT
futech-391	126	1	these	these	DET
futech-391	126	2	characteristics	characteristic	NOUN
futech-391	126	3	highlight	highlight	VERB
futech-391	126	4	the	the	DET
futech-391	126	5	quality	quality	NOUN
futech-391	126	6	of	of	ADP
futech-391	126	7	data	datum	NOUN
futech-391	126	8	produced	produce	VERB
futech-391	126	9	by	by	ADP
futech-391	126	10	this	this	DET
futech-391	126	11	method	method	NOUN
futech-391	126	12	.	.	PUNCT
futech-391	127	1	along	along	ADP
futech-391	127	2	with	with	ADP
futech-391	127	3	consistent	consistent	ADJ
futech-391	127	4	data	datum	NOUN
futech-391	127	5	quality	quality	NOUN
futech-391	127	6	and	and	CCONJ
futech-391	127	7	minimisation	minimisation	NOUN
futech-391	127	8	of	of	ADP
futech-391	127	9	batch	batch	NOUN
futech-391	127	10	effects	effect	NOUN
futech-391	127	11	,	,	PUNCT
futech-391	127	12	high	high	ADJ
futech-391	127	13	feature	feature	NOUN
futech-391	127	14	coverage	coverage	NOUN
futech-391	127	15	was	be	AUX
futech-391	127	16	achieved	achieve	VERB
futech-391	127	17	,	,	PUNCT
futech-391	127	18	creating	create	VERB
futech-391	127	19	a	a	DET
futech-391	127	20	foundation	foundation	NOUN
futech-391	127	21	suitable	suitable	ADJ
futech-391	127	22	for	for	ADP
futech-391	127	23	subsequent	subsequent	ADJ
futech-391	127	24	analyses	analysis	NOUN
futech-391	127	25	using	use	VERB
futech-391	127	26	machine	machine	NOUN
futech-391	127	27	learning	learning	NOUN
futech-391	127	28	.	.	PUNCT
futech-391	128	1	the	the	DET
futech-391	128	2	diverse	diverse	ADJ
futech-391	128	3	molecular	molecular	ADJ
futech-391	128	4	data	datum	NOUN
futech-391	128	5	types	type	NOUN
futech-391	128	6	were	be	AUX
futech-391	128	7	successfully	successfully	ADV
futech-391	128	8	consolidated	consolidate	VERB
futech-391	128	9	,	,	PUNCT
futech-391	128	10	enabling	enable	VERB
futech-391	128	11	the	the	DET
futech-391	128	12	comprehensive	comprehensive	ADJ
futech-391	128	13	characterization	characterization	NOUN
futech-391	128	14	of	of	ADP
futech-391	128	15	diabetic	diabetic	ADJ
futech-391	128	16	nephropathy	nephropathy	ADJ
futech-391	128	17	pathophysiology	pathophysiology	NOUN
futech-391	128	18	at	at	ADP
futech-391	128	19	multiple	multiple	ADJ
futech-391	128	20	biological	biological	ADJ
futech-391	128	21	levels	level	NOUN
futech-391	128	22	,	,	PUNCT
futech-391	128	23	which	which	PRON
futech-391	128	24	,	,	PUNCT
futech-391	128	25	through	through	ADP
futech-391	128	26	downstream	downstream	ADJ
futech-391	128	27	computational	computational	ADJ
futech-391	128	28	analyses	analysis	NOUN
futech-391	128	29	,	,	PUNCT
futech-391	128	30	made	make	VERB
futech-391	128	31	possible	possible	ADJ
futech-391	128	32	the	the	DET
futech-391	128	33	extraction	extraction	NOUN
futech-391	128	34	of	of	ADP
futech-391	128	35	tubular	tubular	ADJ
futech-391	128	36	epithelial	epithelial	ADJ
futech-391	128	37	cell	cell	NOUN
futech-391	128	38	-	-	PUNCT
futech-391	128	39	specific	specific	ADJ
futech-391	128	40	biomarkers	biomarker	NOUN
futech-391	128	41	.	.	PUNCT
futech-391	129	1	the	the	DET
futech-391	129	2	multi	multi	ADJ
futech-391	129	3	-	-	ADJ
futech-391	129	4	omics	omics	ADJ
futech-391	129	5	data	data	NOUN
futech-391	129	6	integration	integration	NOUN
futech-391	129	7	process	process	NOUN
futech-391	129	8	demonstrated	demonstrate	VERB
futech-391	129	9	substantial	substantial	ADJ
futech-391	129	10	improvements	improvement	NOUN
futech-391	129	11	in	in	ADP
futech-391	129	12	data	datum	NOUN
futech-391	129	13	quality	quality	NOUN
futech-391	129	14	and	and	CCONJ
futech-391	129	15	technical	technical	ADJ
futech-391	129	16	variability	variability	NOUN
futech-391	129	17	reduction	reduction	NOUN
futech-391	129	18	,	,	PUNCT
futech-391	129	19	as	as	SCONJ
futech-391	129	20	illustrated	illustrate	VERB
futech-391	129	21	in	in	ADP
futech-391	129	22	figure	figure	NOUN
futech-391	129	23	2	2	NUM
futech-391	129	24	.	.	PUNCT
futech-391	129	25	principal	principal	ADJ
futech-391	129	26	component	component	NOUN
futech-391	129	27	analysis	analysis	NOUN
futech-391	129	28	revealed	reveal	VERB
futech-391	129	29	distinct	distinct	ADJ
futech-391	129	30	clustering	clustering	NOUN
futech-391	129	31	patterns	pattern	NOUN
futech-391	129	32	before	before	ADP
futech-391	129	33	and	and	CCONJ
futech-391	129	34	after	after	ADP
futech-391	129	35	batch	batch	NOUN
futech-391	129	36	effect	effect	NOUN
futech-391	129	37	correction	correction	NOUN
futech-391	129	38	,	,	PUNCT
futech-391	129	39	with	with	ADP
futech-391	129	40	samples	sample	NOUN
futech-391	129	41	initially	initially	ADV
futech-391	129	42	segregating	segregate	VERB
futech-391	129	43	according	accord	VERB
futech-391	129	44	to	to	ADP
futech-391	129	45	experimental	experimental	ADJ
futech-391	129	46	batches	batch	NOUN
futech-391	129	47	rather	rather	ADV
futech-391	129	48	than	than	ADP
futech-391	129	49	biological	biological	ADJ
futech-391	129	50	conditions	condition	NOUN
futech-391	129	51	.	.	PUNCT
futech-391	130	1	the	the	DET
futech-391	130	2	correction	correction	NOUN
futech-391	130	3	procedure	procedure	NOUN
futech-391	130	4	successfully	successfully	ADV
futech-391	130	5	eliminated	eliminate	VERB
futech-391	130	6	technical	technical	ADJ
futech-391	130	7	artifacts	artifact	NOUN
futech-391	130	8	,	,	PUNCT
futech-391	130	9	resulting	result	VERB
futech-391	130	10	in	in	ADP
futech-391	130	11	biologically	biologically	ADV
futech-391	130	12	meaningful	meaningful	ADJ
futech-391	130	13	sample	sample	NOUN
futech-391	130	14	groupings	grouping	NOUN
futech-391	130	15	based	base	VERB
futech-391	130	16	on	on	ADP
futech-391	130	17	disease	disease	NOUN
futech-391	130	18	status	status	NOUN
futech-391	130	19	rather	rather	ADV
futech-391	130	20	than	than	ADP
futech-391	130	21	batch	batch	VERB
futech-391	130	22	origin	origin	NOUN
futech-391	130	23	.	.	PUNCT
futech-391	131	1	as	as	SCONJ
futech-391	131	2	shown	show	VERB
futech-391	131	3	in	in	ADP
futech-391	131	4	figure	figure	NOUN
futech-391	131	5	2(a	2(a	NUM
futech-391	131	6	)	)	PUNCT
futech-391	131	7	,	,	PUNCT
futech-391	131	8	the	the	DET
futech-391	131	9	pre	pre	ADJ
futech-391	131	10	-	-	ADJ
futech-391	131	11	correction	correction	ADJ
futech-391	131	12	data	datum	NOUN
futech-391	131	13	exhibited	exhibit	VERB
futech-391	131	14	clear	clear	ADJ
futech-391	131	15	batch	batch	NOUN
futech-391	131	16	-	-	PUNCT
futech-391	131	17	driven	drive	VERB
futech-391	131	18	clustering	clustering	NOUN
futech-391	131	19	with	with	ADP
futech-391	131	20	samples	sample	NOUN
futech-391	131	21	from	from	ADP
futech-391	131	22	different	different	ADJ
futech-391	131	23	batches	batch	NOUN
futech-391	131	24	occupying	occupy	VERB
futech-391	131	25	distinct	distinct	ADJ
futech-391	131	26	regions	region	NOUN
futech-391	131	27	of	of	ADP
futech-391	131	28	the	the	DET
futech-391	131	29	pca	pca	NOUN
futech-391	131	30	space	space	NOUN
futech-391	131	31	,	,	PUNCT
futech-391	131	32	while	while	SCONJ
futech-391	131	33	post	post	ADJ
futech-391	131	34	-	-	ADJ
futech-391	131	35	correction	correction	ADJ
futech-391	131	36	analysis	analysis	NOUN
futech-391	131	37	revealed	reveal	VERB
futech-391	131	38	appropriate	appropriate	ADJ
futech-391	131	39	separation	separation	NOUN
futech-391	131	40	between	between	ADP
futech-391	131	41	control	control	NOUN
futech-391	131	42	and	and	CCONJ
futech-391	131	43	diabetic	diabetic	ADJ
futech-391	131	44	nephropathy	nephropathy	NOUN
futech-391	131	45	samples	sample	NOUN
futech-391	131	46	along	along	ADP
futech-391	131	47	the	the	DET
futech-391	131	48	primary	primary	ADJ
futech-391	131	49	axes	axis	NOUN
futech-391	131	50	of	of	ADP
futech-391	131	51	variation	variation	NOUN
futech-391	131	52	.	.	PUNCT
futech-391	132	1	the	the	DET
futech-391	132	2	first	first	ADJ
futech-391	132	3	two	two	NUM
futech-391	132	4	principal	principal	ADJ
futech-391	132	5	components	component	NOUN
futech-391	132	6	explained	explain	VERB
futech-391	132	7	45.2	45.2	NUM
futech-391	132	8	%	%	NOUN
futech-391	132	9	and	and	CCONJ
futech-391	132	10	23.8	23.8	NUM
futech-391	132	11	%	%	NOUN
futech-391	132	12	of	of	ADP
futech-391	132	13	total	total	ADJ
futech-391	132	14	variance	variance	NOUN
futech-391	132	15	,	,	PUNCT
futech-391	132	16	respectively	respectively	ADV
futech-391	132	17	,	,	PUNCT
futech-391	132	18	indicating	indicate	VERB
futech-391	132	19	effective	effective	ADJ
futech-391	132	20	dimensionality	dimensionality	NOUN
futech-391	132	21	reduction	reduction	NOUN
futech-391	132	22	while	while	SCONJ
futech-391	132	23	preserving	preserve	VERB
futech-391	132	24	biological	biological	ADJ
futech-391	132	25	signal	signal	NOUN
futech-391	132	26	integrity	integrity	NOUN
futech-391	132	27	.	.	PUNCT
futech-391	133	1	data	datum	NOUN
futech-391	133	2	distribution	distribution	NOUN
futech-391	133	3	analysis	analysis	NOUN
futech-391	133	4	further	far	ADV
futech-391	133	5	confirmed	confirm	VERB
futech-391	133	6	the	the	DET
futech-391	133	7	effectiveness	effectiveness	NOUN
futech-391	133	8	of	of	ADP
futech-391	133	9	normalization	normalization	NOUN
futech-391	133	10	procedures	procedure	NOUN
futech-391	133	11	across	across	ADP
futech-391	133	12	all	all	DET
futech-391	133	13	molecular	molecular	ADJ
futech-391	133	14	platforms	platform	NOUN
futech-391	133	15	,	,	PUNCT
futech-391	133	16	as	as	SCONJ
futech-391	133	17	demonstrated	demonstrate	VERB
futech-391	133	18	in	in	ADP
futech-391	133	19	figure	figure	NOUN
futech-391	133	20	2(b	2(b	NUM
futech-391	133	21	)	)	PUNCT
futech-391	133	22	.	.	PUNCT
futech-391	134	1	the	the	DET
futech-391	134	2	prenormalization	prenormalization	NOUN
futech-391	134	3	distribution	distribution	NOUN
futech-391	134	4	exhibited	exhibit	VERB
futech-391	134	5	multiple	multiple	ADJ
futech-391	134	6	peaks	peak	NOUN
futech-391	134	7	and	and	CCONJ
futech-391	134	8	irregular	irregular	ADJ
futech-391	134	9	patterns	pattern	NOUN
futech-391	134	10	characteristic	characteristic	ADJ
futech-391	134	11	of	of	ADP
futech-391	134	12	batch	batch	NOUN
futech-391	134	13	effects	effect	NOUN
futech-391	134	14	and	and	CCONJ
futech-391	134	15	platform	platform	NOUN
futech-391	134	16	-	-	PUNCT
futech-391	134	17	specific	specific	ADJ
futech-391	134	18	variations	variation	NOUN
futech-391	134	19	,	,	PUNCT
futech-391	134	20	with	with	ADP
futech-391	134	21	a	a	DET
futech-391	134	22	coefficient	coefficient	NOUN
futech-391	134	23	of	of	ADP
futech-391	134	24	variation	variation	NOUN
futech-391	134	25	of	of	ADP
futech-391	134	26	14.8	14.8	NUM
futech-391	134	27	%	%	NOUN
futech-391	134	28	.	.	PUNCT
futech-391	135	1	following	follow	VERB
futech-391	135	2	comprehensive	comprehensive	ADJ
futech-391	135	3	normalization	normalization	NOUN
futech-391	135	4	,	,	PUNCT
futech-391	135	5	the	the	DET
futech-391	135	6	data	data	NOUN
futech-391	135	7	distribution	distribution	NOUN
futech-391	135	8	converged	converge	VERB
futech-391	135	9	to	to	ADP
futech-391	135	10	a	a	DET
futech-391	135	11	well	well	ADV
futech-391	135	12	-	-	PUNCT
futech-391	135	13	centered	center	VERB
futech-391	135	14	,	,	PUNCT
futech-391	135	15	unimodal	unimodal	ADJ
futech-391	135	16	pattern	pattern	NOUN
futech-391	135	17	with	with	ADP
futech-391	135	18	significantly	significantly	ADV
futech-391	135	19	reduced	reduce	VERB
futech-391	135	20	coefficient	coefficient	NOUN
futech-391	135	21	of	of	ADP
futech-391	135	22	variation	variation	NOUN
futech-391	135	23	of	of	ADP
futech-391	135	24	3.2	3.2	NUM
futech-391	135	25	%	%	NOUN
futech-391	135	26	,	,	PUNCT
futech-391	135	27	representing	represent	VERB
futech-391	135	28	a	a	DET
futech-391	135	29	78	78	NUM
futech-391	135	30	%	%	NOUN
futech-391	135	31	improvement	improvement	NOUN
futech-391	135	32	in	in	ADP
futech-391	135	33	data	datum	NOUN
futech-391	135	34	consistency	consistency	NOUN
futech-391	135	35	.	.	PUNCT
futech-391	136	1	this	this	DET
futech-391	136	2	dramatic	dramatic	ADJ
futech-391	136	3	reduction	reduction	NOUN
futech-391	136	4	in	in	ADP
futech-391	136	5	technical	technical	ADJ
futech-391	136	6	variability	variability	NOUN
futech-391	136	7	established	establish	VERB
futech-391	136	8	optimal	optimal	ADJ
futech-391	136	9	conditions	condition	NOUN
futech-391	136	10	for	for	ADP
futech-391	136	11	subsequent	subsequent	ADJ
futech-391	136	12	machine	machine	NOUN
futech-391	136	13	learning	learning	NOUN
futech-391	136	14	analyses	analysis	NOUN
futech-391	136	15	by	by	ADP
futech-391	136	16	ensuring	ensure	VERB
futech-391	136	17	that	that	SCONJ
futech-391	136	18	biological	biological	ADJ
futech-391	136	19	signals	signal	NOUN
futech-391	136	20	rather	rather	ADV
futech-391	136	21	than	than	ADP
futech-391	136	22	technical	technical	ADJ
futech-391	136	23	artifacts	artifact	NOUN
futech-391	136	24	would	would	AUX
futech-391	136	25	drive	drive	VERB
futech-391	136	26	biomarker	biomarker	NOUN
futech-391	136	27	discovery	discovery	NOUN
futech-391	136	28	.	.	PUNCT
futech-391	137	1	the	the	DET
futech-391	137	2	normalized	normalize	VERB
futech-391	137	3	expression	expression	NOUN
futech-391	137	4	values	value	NOUN
futech-391	137	5	demonstrated	demonstrate	VERB
futech-391	137	6	appropriate	appropriate	ADJ
futech-391	137	7	statistical	statistical	ADJ
futech-391	137	8	properties	property	NOUN
futech-391	137	9	with	with	ADP
futech-391	137	10	symmetric	symmetric	ADJ
futech-391	137	11	distribution	distribution	NOUN
futech-391	137	12	around	around	ADP
futech-391	137	13	zero	zero	NUM
futech-391	137	14	,	,	PUNCT
futech-391	137	15	confirming	confirm	VERB
futech-391	137	16	successful	successful	ADJ
futech-391	137	17	standardization	standardization	NOUN
futech-391	137	18	across	across	ADP
futech-391	137	19	different	different	ADJ
futech-391	137	20	omics	omic	NOUN
futech-391	137	21	platforms	platform	NOUN
futech-391	137	22	and	and	CCONJ
futech-391	137	23	experimental	experimental	ADJ
futech-391	137	24	conditions	condition	NOUN
futech-391	137	25	.	.	PUNCT
futech-391	138	1	figure	figure	NOUN
futech-391	138	2	2	2	NUM
futech-391	138	3	.	.	PUNCT
futech-391	139	1	multi	multi	ADJ
futech-391	139	2	-	-	ADJ
futech-391	139	3	omics	omics	ADJ
futech-391	139	4	data	data	NOUN
futech-391	139	5	integration	integration	NOUN
futech-391	139	6	quality	quality	NOUN
futech-391	139	7	assessment	assessment	NOUN
futech-391	139	8	(	(	PUNCT
futech-391	139	9	a)pca	a)pca	NOUN
futech-391	139	10	analysis	analysis	NOUN
futech-391	139	11	:	:	PUNCT
futech-391	139	12	batch	batch	NOUN
futech-391	139	13	effect	effect	NOUN
futech-391	139	14	correction	correction	NOUN
futech-391	139	15	,	,	PUNCT
futech-391	139	16	(	(	PUNCT
futech-391	139	17	b)data	b)data	NOUN
futech-391	139	18	distribution	distribution	NOUN
futech-391	139	19	normalization	normalization	NOUN
futech-391	139	20	3.2	3.2	NUM
futech-391	139	21	machine	machine	NOUN
futech-391	139	22	learning	learning	NOUN
futech-391	139	23	model	model	NOUN
futech-391	139	24	performance	performance	NOUN
futech-391	139	25	evaluation	evaluation	NOUN
futech-391	139	26	the	the	DET
futech-391	139	27	comparative	comparative	ADJ
futech-391	139	28	analysis	analysis	NOUN
futech-391	139	29	of	of	ADP
futech-391	139	30	machine	machine	NOUN
futech-391	139	31	learning	learn	VERB
futech-391	139	32	algorithms	algorithm	NOUN
futech-391	139	33	demonstrated	demonstrate	VERB
futech-391	139	34	varying	vary	VERB
futech-391	139	35	degrees	degree	NOUN
futech-391	139	36	of	of	ADP
futech-391	139	37	predictive	predictive	ADJ
futech-391	139	38	performance	performance	NOUN
futech-391	139	39	for	for	ADP
futech-391	139	40	diabetic	diabetic	ADJ
futech-391	139	41	nephropathy	nephropathy	ADJ
futech-391	139	42	classification	classification	NOUN
futech-391	139	43	,	,	PUNCT
futech-391	139	44	as	as	SCONJ
futech-391	139	45	presented	present	VERB
futech-391	139	46	in	in	ADP
futech-391	139	47	table	table	NOUN
futech-391	139	48	2	2	NUM
futech-391	139	49	.	.	PUNCT
futech-391	140	1	among	among	ADP
futech-391	140	2	the	the	DET
futech-391	140	3	individual	individual	ADJ
futech-391	140	4	algorithms	algorithm	NOUN
futech-391	140	5	,	,	PUNCT
futech-391	140	6	xgboost	xgboost	PROPN
futech-391	140	7	exhibited	exhibit	VERB
futech-391	140	8	superior	superior	ADJ
futech-391	140	9	performance	performance	NOUN
futech-391	140	10	with	with	ADP
futech-391	140	11	an	an	DET
futech-391	140	12	accuracy	accuracy	NOUN
futech-391	140	13	of	of	ADP
futech-391	140	14	89.7	89.7	NUM
futech-391	140	15	%	%	NOUN
futech-391	140	16	,	,	PUNCT
futech-391	140	17	sensitivity	sensitivity	NOUN
futech-391	140	18	of	of	ADP
futech-391	140	19	87.9	87.9	NUM
futech-391	140	20	%	%	NOUN
futech-391	140	21	,	,	PUNCT
futech-391	140	22	and	and	CCONJ
futech-391	140	23	specificity	specificity	NOUN
futech-391	140	24	of	of	ADP
futech-391	140	25	91.2	91.2	NUM
futech-391	140	26	%	%	NOUN
futech-391	140	27	,	,	PUNCT
futech-391	140	28	achieving	achieve	VERB
futech-391	140	29	an	an	DET
futech-391	140	30	area	area	NOUN
futech-391	140	31	under	under	ADP
futech-391	140	32	the	the	DET
futech-391	140	33	curve	curve	NOUN
futech-391	140	34	of	of	ADP
futech-391	140	35	0.934	0.934	NUM
futech-391	140	36	.	.	PUNCT
futech-391	141	1	random	random	ADJ
futech-391	141	2	forest	forest	NOUN
futech-391	141	3	demonstrated	demonstrate	VERB
futech-391	141	4	moderate	moderate	ADJ
futech-391	141	5	performance	performance	NOUN
futech-391	141	6	with	with	ADP
futech-391	141	7	87.3	87.3	NUM
futech-391	141	8	%	%	NOUN
futech-391	141	9	accuracy	accuracy	NOUN
futech-391	141	10	w.	w.	PROPN
futech-391	141	11	li	li	PROPN
futech-391	141	12	&	&	CCONJ
futech-391	141	13	sp	sp	PROPN
futech-391	141	14	.	.	PROPN
futech-391	141	15	chandran	chandran	PROPN
futech-391	141	16	/future	/future	PUNCT
futech-391	141	17	technology	technology	PROPN
futech-391	141	18	august	august	PROPN
futech-391	141	19	2025|	2025|	NUM
futech-391	141	20	volume	volume	NOUN
futech-391	141	21	04	04	NUM
futech-391	142	1	|	|	NOUN
futech-391	142	2	issue	issue	NOUN
futech-391	142	3	03	03	NUM
futech-391	143	1	|	|	ADV
futech-391	143	2	pages	page	NOUN
futech-391	143	3	193	193	NUM
futech-391	143	4	-	-	SYM
futech-391	143	5	203	203	NUM
futech-391	143	6	197	197	NUM
futech-391	143	7	and	and	CCONJ
futech-391	143	8	an	an	DET
futech-391	143	9	auc	auc	NOUN
futech-391	143	10	of	of	ADP
futech-391	143	11	0.912	0.912	NUM
futech-391	143	12	,	,	PUNCT
futech-391	143	13	while	while	SCONJ
futech-391	143	14	support	support	NOUN
futech-391	143	15	vector	vector	NOUN
futech-391	143	16	machine	machine	NOUN
futech-391	143	17	showed	show	VERB
futech-391	143	18	the	the	DET
futech-391	143	19	lowest	low	ADJ
futech-391	143	20	individual	individual	ADJ
futech-391	143	21	performance	performance	NOUN
futech-391	143	22	with	with	ADP
futech-391	143	23	83.1	83.1	NUM
futech-391	143	24	%	%	NOUN
futech-391	143	25	accuracy	accuracy	NOUN
futech-391	143	26	and	and	CCONJ
futech-391	143	27	an	an	DET
futech-391	143	28	auc	auc	NOUN
futech-391	143	29	of	of	ADP
futech-391	143	30	0.876	0.876	NUM
futech-391	143	31	.	.	PUNCT
futech-391	144	1	the	the	DET
futech-391	144	2	f1	f1	PROPN
futech-391	144	3	-	-	PUNCT
futech-391	144	4	scores	score	NOUN
futech-391	144	5	ranged	range	VERB
futech-391	144	6	from	from	ADP
futech-391	144	7	0.823	0.823	NUM
futech-391	144	8	for	for	ADP
futech-391	144	9	svm	svm	NOUN
futech-391	144	10	to	to	ADP
futech-391	144	11	0.895	0.895	NUM
futech-391	144	12	for	for	ADP
futech-391	144	13	xgboost	xgboost	NUM
futech-391	144	14	,	,	PUNCT
futech-391	144	15	indicating	indicate	VERB
futech-391	144	16	balanced	balanced	ADJ
futech-391	144	17	precision	precision	NOUN
futech-391	144	18	and	and	CCONJ
futech-391	144	19	recall	recall	NOUN
futech-391	144	20	across	across	ADP
futech-391	144	21	different	different	ADJ
futech-391	144	22	classification	classification	NOUN
futech-391	144	23	thresholds	threshold	NOUN
futech-391	144	24	.	.	PUNCT
futech-391	145	1	all	all	DET
futech-391	145	2	confidence	confidence	NOUN
futech-391	145	3	intervals	interval	NOUN
futech-391	145	4	demonstrated	demonstrate	VERB
futech-391	145	5	statistical	statistical	ADJ
futech-391	145	6	significance	significance	NOUN
futech-391	145	7	with	with	ADP
futech-391	145	8	nonoverlapping	nonoverlapping	NOUN
futech-391	145	9	ranges	range	NOUN
futech-391	145	10	between	between	ADP
futech-391	145	11	the	the	DET
futech-391	145	12	best	good	ADJ
futech-391	145	13	and	and	CCONJ
futech-391	145	14	worst	bad	ADJ
futech-391	145	15	performing	performing	NOUN
futech-391	145	16	models	model	NOUN
futech-391	145	17	.	.	PUNCT
futech-391	146	1	the	the	DET
futech-391	146	2	ensemble	ensemble	ADJ
futech-391	146	3	learning	learning	NOUN
futech-391	146	4	approach	approach	NOUN
futech-391	146	5	achieved	achieve	VERB
futech-391	146	6	optimal	optimal	ADJ
futech-391	146	7	classification	classification	NOUN
futech-391	146	8	performance	performance	NOUN
futech-391	146	9	by	by	ADP
futech-391	146	10	combining	combine	VERB
futech-391	146	11	predictions	prediction	NOUN
futech-391	146	12	from	from	ADP
futech-391	146	13	all	all	DET
futech-391	146	14	three	three	NUM
futech-391	146	15	individual	individual	ADJ
futech-391	146	16	algorithms	algorithm	NOUN
futech-391	146	17	through	through	ADP
futech-391	146	18	weighted	weight	VERB
futech-391	146	19	voting	voting	NOUN
futech-391	146	20	mechanisms	mechanism	NOUN
futech-391	146	21	,	,	PUNCT
futech-391	146	22	as	as	SCONJ
futech-391	146	23	indicated	indicate	VERB
futech-391	146	24	in	in	ADP
futech-391	146	25	table	table	NOUN
futech-391	146	26	2	2	NUM
futech-391	146	27	.	.	PUNCT
futech-391	147	1	the	the	DET
futech-391	147	2	ensemble	ensemble	ADJ
futech-391	147	3	model	model	NOUN
futech-391	147	4	attained	attain	VERB
futech-391	147	5	the	the	DET
futech-391	147	6	highest	high	ADJ
futech-391	147	7	accuracy	accuracy	NOUN
futech-391	147	8	of	of	ADP
futech-391	147	9	91.4	91.4	NUM
futech-391	147	10	%	%	NOUN
futech-391	147	11	,	,	PUNCT
futech-391	147	12	with	with	ADP
futech-391	147	13	sensitivity	sensitivity	NOUN
futech-391	147	14	and	and	CCONJ
futech-391	147	15	specificity	specificity	NOUN
futech-391	147	16	values	value	NOUN
futech-391	147	17	of	of	ADP
futech-391	147	18	89.6	89.6	NUM
futech-391	147	19	%	%	NOUN
futech-391	147	20	and	and	CCONJ
futech-391	147	21	92.8	92.8	NUM
futech-391	147	22	%	%	NOUN
futech-391	147	23	,	,	PUNCT
futech-391	147	24	respectively	respectively	ADV
futech-391	147	25	.	.	PUNCT
futech-391	148	1	the	the	DET
futech-391	148	2	ensemble	ensemble	ADJ
futech-391	148	3	auc	auc	NOUN
futech-391	148	4	reached	reach	VERB
futech-391	148	5	0.947	0.947	NUM
futech-391	148	6	with	with	ADP
futech-391	148	7	a	a	DET
futech-391	148	8	95	95	NUM
futech-391	148	9	%	%	NOUN
futech-391	148	10	confidence	confidence	NOUN
futech-391	148	11	interval	interval	NOUN
futech-391	148	12	of	of	ADP
futech-391	148	13	0.929	0.929	NUM
futech-391	148	14	-	-	SYM
futech-391	148	15	0.965	0.965	NUM
futech-391	148	16	,	,	PUNCT
futech-391	148	17	representing	represent	VERB
futech-391	148	18	a	a	DET
futech-391	148	19	significant	significant	ADJ
futech-391	148	20	improvement	improvement	NOUN
futech-391	148	21	over	over	ADP
futech-391	148	22	the	the	DET
futech-391	148	23	individual	individual	ADJ
futech-391	148	24	algorithm	algorithm	NOUN
futech-391	148	25	.	.	PUNCT
futech-391	149	1	the	the	DET
futech-391	149	2	f1	f1	NOUN
futech-391	149	3	-	-	PUNCT
futech-391	149	4	score	score	NOUN
futech-391	149	5	of	of	ADP
futech-391	149	6	0.912	0.912	NUM
futech-391	149	7	indicated	indicate	VERB
futech-391	149	8	excellent	excellent	ADJ
futech-391	149	9	balance	balance	NOUN
futech-391	149	10	between	between	ADP
futech-391	149	11	precision	precision	NOUN
futech-391	149	12	and	and	CCONJ
futech-391	149	13	recall	recall	NOUN
futech-391	149	14	,	,	PUNCT
futech-391	149	15	confirming	confirm	VERB
futech-391	149	16	the	the	DET
futech-391	149	17	ensemble	ensemble	ADJ
futech-391	149	18	approach	approach	NOUN
futech-391	149	19	's	's	PART
futech-391	149	20	superiority	superiority	NOUN
futech-391	149	21	in	in	ADP
futech-391	149	22	identifying	identify	VERB
futech-391	149	23	both	both	CCONJ
futech-391	149	24	positive	positive	ADJ
futech-391	149	25	and	and	CCONJ
futech-391	149	26	negative	negative	ADJ
futech-391	149	27	cases	case	NOUN
futech-391	149	28	.	.	PUNCT
futech-391	150	1	these	these	DET
futech-391	150	2	performance	performance	NOUN
futech-391	150	3	metrics	metric	NOUN
futech-391	150	4	substantially	substantially	ADV
futech-391	150	5	exceeded	exceed	VERB
futech-391	150	6	conventional	conventional	ADJ
futech-391	150	7	clinical	clinical	ADJ
futech-391	150	8	diagnostic	diagnostic	ADJ
futech-391	150	9	markers	marker	NOUN
futech-391	150	10	,	,	PUNCT
futech-391	150	11	demonstrating	demonstrate	VERB
futech-391	150	12	the	the	DET
futech-391	150	13	potential	potential	NOUN
futech-391	150	14	of	of	ADP
futech-391	150	15	multi	multi	ADJ
futech-391	150	16	-	-	ADJ
futech-391	150	17	omics	omics	ADJ
futech-391	150	18	machine	machine	NOUN
futech-391	150	19	learning	learning	NOUN
futech-391	150	20	approaches	approach	NOUN
futech-391	150	21	for	for	ADP
futech-391	150	22	enhanced	enhanced	ADJ
futech-391	150	23	diabetic	diabetic	ADJ
futech-391	150	24	nephropathy	nephropathy	ADJ
futech-391	150	25	detection	detection	NOUN
futech-391	150	26	and	and	CCONJ
futech-391	150	27	risk	risk	NOUN
futech-391	150	28	stratification	stratification	NOUN
futech-391	150	29	in	in	ADP
futech-391	150	30	clinical	clinical	ADJ
futech-391	150	31	practice	practice	NOUN
futech-391	150	32	.	.	PUNCT
futech-391	151	1	table	table	NOUN
futech-391	151	2	2	2	NUM
futech-391	151	3	.	.	PUNCT
futech-391	151	4	machine	machine	NOUN
futech-391	151	5	learning	learning	NOUN
futech-391	151	6	model	model	NOUN
futech-391	151	7	performance	performance	NOUN
futech-391	151	8	comparison	comparison	NOUN
futech-391	151	9	algorithm	algorithm	NOUN
futech-391	151	10	accuracy	accuracy	NOUN
futech-391	151	11	(	(	PUNCT
futech-391	151	12	%	%	INTJ
futech-391	151	13	)	)	PUNCT
futech-391	151	14	sensitivity	sensitivity	NOUN
futech-391	151	15	(	(	PUNCT
futech-391	151	16	%	%	INTJ
futech-391	151	17	)	)	PUNCT
futech-391	151	18	specificity	specificity	NOUN
futech-391	151	19	(	(	PUNCT
futech-391	151	20	%	%	INTJ
futech-391	151	21	)	)	PUNCT
futech-391	151	22	auc	auc	NOUN
futech-391	151	23	f1score	f1score	NOUN
futech-391	151	24	95	95	NUM
futech-391	151	25	%	%	NOUN
futech-391	151	26	ci	ci	NOUN
futech-391	151	27	random	random	ADJ
futech-391	151	28	forest	forest	NOUN
futech-391	151	29	87.3	87.3	NUM
futech-391	151	30	84.5	84.5	NUM
futech-391	151	31	89.8	89.8	NUM
futech-391	151	32	0.912	0.912	NUM
futech-391	151	33	0.869	0.869	NUM
futech-391	151	34	0.891	0.891	NUM
futech-391	151	35	0.933	0.933	NUM
futech-391	151	36	svm	svm	PROPN
futech-391	151	37	83.1	83.1	NUM
futech-391	151	38	81.2	81.2	NUM
futech-391	151	39	85.6	85.6	NUM
futech-391	151	40	0.876	0.876	NUM
futech-391	151	41	0.823	0.823	NUM
futech-391	151	42	0.851	0.851	NUM
futech-391	151	43	0.901	0.901	NUM
futech-391	151	44	xgboost	xgboost	ADV
futech-391	151	45	89.7	89.7	NUM
futech-391	151	46	87.9	87.9	NUM
futech-391	151	47	91.2	91.2	NUM
futech-391	151	48	0.934	0.934	NUM
futech-391	151	49	0.895	0.895	NUM
futech-391	151	50	0.915	0.915	NUM
futech-391	151	51	0.953	0.953	NUM
futech-391	151	52	ensemble	ensemble	ADJ
futech-391	151	53	91.4	91.4	NUM
futech-391	151	54	89.6	89.6	NUM
futech-391	151	55	92.8	92.8	NUM
futech-391	151	56	0.947	0.947	NUM
futech-391	151	57	0.912	0.912	NUM
futech-391	151	58	0.929	0.929	NUM
futech-391	151	59	0.965	0.965	NUM
futech-391	151	60	note	note	NOUN
futech-391	151	61	:	:	PUNCT
futech-391	151	62	auc	auc	NOUN
futech-391	151	63	:	:	PUNCT
futech-391	151	64	area	area	NOUN
futech-391	151	65	under	under	ADP
futech-391	151	66	the	the	DET
futech-391	151	67	receiver	receiver	NOUN
futech-391	151	68	operating	operate	VERB
futech-391	151	69	characteristic	characteristic	ADJ
futech-391	151	70	curve	curve	NOUN
futech-391	151	71	;	;	PUNCT
futech-391	151	72	ci	ci	NOUN
futech-391	151	73	:	:	PUNCT
futech-391	151	74	confidence	confidence	NOUN
futech-391	151	75	interval	interval	NOUN
futech-391	151	76	.	.	PUNCT
futech-391	152	1	performance	performance	NOUN
futech-391	152	2	metrics	metric	NOUN
futech-391	152	3	were	be	AUX
futech-391	152	4	evaluated	evaluate	VERB
futech-391	152	5	using	use	VERB
futech-391	152	6	5	5	NUM
futech-391	152	7	-	-	ADJ
futech-391	152	8	fold	fold	ADJ
futech-391	152	9	cross	cross	NOUN
futech-391	152	10	-	-	NOUN
futech-391	152	11	validation	validation	NOUN
futech-391	152	12	on	on	ADP
futech-391	152	13	the	the	DET
futech-391	152	14	integrated	integrate	VERB
futech-391	152	15	multi	multi	ADJ
futech-391	152	16	-	-	ADJ
futech-391	152	17	omics	omics	ADJ
futech-391	152	18	dataset	dataset	NOUN
futech-391	152	19	(	(	PUNCT
futech-391	152	20	n=156	n=156	PROPN
futech-391	152	21	)	)	PUNCT
futech-391	152	22	.	.	PUNCT
futech-391	153	1	the	the	DET
futech-391	153	2	receiver	receiver	NOUN
futech-391	153	3	operating	operate	VERB
futech-391	153	4	characteristic	characteristic	ADJ
futech-391	153	5	curve	curve	NOUN
futech-391	153	6	analysis	analysis	NOUN
futech-391	153	7	revealed	reveal	VERB
futech-391	153	8	distinct	distinct	ADJ
futech-391	153	9	performance	performance	NOUN
futech-391	153	10	patterns	pattern	NOUN
futech-391	153	11	across	across	ADP
futech-391	153	12	the	the	DET
futech-391	153	13	implemented	implement	VERB
futech-391	153	14	machine	machine	NOUN
futech-391	153	15	learning	learning	NOUN
futech-391	153	16	algorithms	algorithm	NOUN
futech-391	153	17	,	,	PUNCT
futech-391	153	18	as	as	SCONJ
futech-391	153	19	illustrated	illustrate	VERB
futech-391	153	20	in	in	ADP
futech-391	153	21	figure	figure	NOUN
futech-391	153	22	3(a	3(a	NUM
futech-391	153	23	)	)	PUNCT
futech-391	153	24	.	.	PUNCT
futech-391	154	1	the	the	DET
futech-391	154	2	ensemble	ensemble	ADJ
futech-391	154	3	model	model	NOUN
futech-391	154	4	demonstrated	demonstrate	VERB
futech-391	154	5	superior	superior	ADJ
futech-391	154	6	discriminative	discriminative	NOUN
futech-391	154	7	capability	capability	NOUN
futech-391	154	8	with	with	ADP
futech-391	154	9	the	the	DET
futech-391	154	10	highest	high	ADJ
futech-391	154	11	area	area	NOUN
futech-391	154	12	under	under	ADP
futech-391	154	13	the	the	DET
futech-391	154	14	curve	curve	NOUN
futech-391	154	15	,	,	PUNCT
futech-391	154	16	followed	follow	VERB
futech-391	154	17	closely	closely	ADV
futech-391	154	18	by	by	ADP
futech-391	154	19	xgboost	xgboost	PROPN
futech-391	154	20	,	,	PUNCT
futech-391	154	21	while	while	SCONJ
futech-391	154	22	support	support	NOUN
futech-391	154	23	vector	vector	NOUN
futech-391	154	24	machine	machine	NOUN
futech-391	154	25	exhibited	exhibit	VERB
futech-391	154	26	the	the	DET
futech-391	154	27	most	most	ADV
futech-391	154	28	conservative	conservative	ADJ
futech-391	154	29	performance	performance	NOUN
futech-391	154	30	profile	profile	NOUN
futech-391	154	31	.	.	PUNCT
futech-391	155	1	the	the	DET
futech-391	155	2	roc	roc	PROPN
futech-391	155	3	curves	curve	NOUN
futech-391	155	4	displayed	display	VERB
futech-391	155	5	optimal	optimal	ADJ
futech-391	155	6	sensitivityspecificity	sensitivityspecificity	NOUN
futech-391	155	7	trade	trade	NOUN
futech-391	155	8	-	-	PUNCT
futech-391	155	9	offs	off	NOUN
futech-391	155	10	,	,	PUNCT
futech-391	155	11	with	with	ADP
futech-391	155	12	the	the	DET
futech-391	155	13	ensemble	ensemble	ADJ
futech-391	155	14	approach	approach	NOUN
futech-391	155	15	achieving	achieve	VERB
futech-391	155	16	the	the	DET
futech-391	155	17	steepest	steep	ADJ
futech-391	155	18	initial	initial	ADJ
futech-391	155	19	rise	rise	NOUN
futech-391	155	20	and	and	CCONJ
futech-391	155	21	maintaining	maintain	VERB
futech-391	155	22	consistently	consistently	ADV
futech-391	155	23	higher	high	ADJ
futech-391	155	24	true	true	ADJ
futech-391	155	25	positive	positive	ADJ
futech-391	155	26	rates	rate	NOUN
futech-391	155	27	across	across	ADP
futech-391	155	28	all	all	DET
futech-391	155	29	false	false	ADJ
futech-391	155	30	positive	positive	ADJ
futech-391	155	31	rate	rate	NOUN
futech-391	155	32	thresholds	threshold	NOUN
futech-391	155	33	.	.	PUNCT
futech-391	156	1	the	the	DET
futech-391	156	2	curves	curve	NOUN
futech-391	156	3	converged	converge	VERB
futech-391	156	4	toward	toward	ADP
futech-391	156	5	the	the	DET
futech-391	156	6	upper	upper	ADV
futech-391	156	7	-	-	PUNCT
futech-391	156	8	left	left	ADJ
futech-391	156	9	corner	corner	NOUN
futech-391	156	10	of	of	ADP
futech-391	156	11	the	the	DET
futech-391	156	12	roc	roc	PROPN
futech-391	156	13	space	space	NOUN
futech-391	156	14	,	,	PUNCT
futech-391	156	15	indicating	indicate	VERB
futech-391	156	16	robust	robust	ADJ
futech-391	156	17	classification	classification	NOUN
futech-391	156	18	performance	performance	NOUN
futech-391	156	19	that	that	PRON
futech-391	156	20	substantially	substantially	ADV
futech-391	156	21	exceeded	exceed	VERB
futech-391	156	22	random	random	ADJ
futech-391	156	23	chance	chance	NOUN
futech-391	156	24	predictions	prediction	NOUN
futech-391	156	25	.	.	PUNCT
futech-391	157	1	the	the	DET
futech-391	157	2	comprehensive	comprehensive	ADJ
futech-391	157	3	performance	performance	NOUN
futech-391	157	4	metric	metric	ADJ
futech-391	157	5	comparison	comparison	NOUN
futech-391	157	6	demonstrated	demonstrate	VERB
futech-391	157	7	the	the	DET
futech-391	157	8	ensemble	ensemble	ADJ
futech-391	157	9	model	model	NOUN
futech-391	157	10	's	's	PART
futech-391	157	11	superiority	superiority	NOUN
futech-391	157	12	across	across	ADP
futech-391	157	13	all	all	DET
futech-391	157	14	evaluated	evaluated	ADJ
futech-391	157	15	parameters	parameter	NOUN
futech-391	157	16	,	,	PUNCT
futech-391	157	17	as	as	SCONJ
futech-391	157	18	shown	show	VERB
futech-391	157	19	in	in	ADP
futech-391	157	20	figure	figure	NOUN
futech-391	157	21	3(b	3(b	NUM
futech-391	157	22	)	)	PUNCT
futech-391	157	23	.	.	PUNCT
futech-391	158	1	the	the	DET
futech-391	158	2	radar	radar	NOUN
futech-391	158	3	plot	plot	NOUN
futech-391	158	4	visualization	visualization	NOUN
futech-391	158	5	revealed	reveal	VERB
futech-391	158	6	balanced	balanced	ADJ
futech-391	158	7	performance	performance	NOUN
futech-391	158	8	profiles	profile	NOUN
futech-391	158	9	,	,	PUNCT
futech-391	158	10	with	with	ADP
futech-391	158	11	the	the	DET
futech-391	158	12	ensemble	ensemble	ADJ
futech-391	158	13	algorithm	algorithm	NOUN
futech-391	158	14	achieving	achieve	VERB
futech-391	158	15	the	the	DET
futech-391	158	16	largest	large	ADJ
futech-391	158	17	coverage	coverage	NOUN
futech-391	158	18	area	area	NOUN
futech-391	158	19	and	and	CCONJ
futech-391	158	20	most	most	ADJ
futech-391	158	21	uniform	uniform	ADJ
futech-391	158	22	metric	metric	ADJ
futech-391	158	23	distribution	distribution	NOUN
futech-391	158	24	.	.	PUNCT
futech-391	159	1	xgboost	xgboost	PROPN
futech-391	159	2	displayed	display	VERB
futech-391	159	3	competitive	competitive	ADJ
futech-391	159	4	performance	performance	NOUN
futech-391	159	5	with	with	ADP
futech-391	159	6	slight	slight	ADJ
futech-391	159	7	variations	variation	NOUN
futech-391	159	8	in	in	ADP
futech-391	159	9	sensitivity	sensitivity	NOUN
futech-391	159	10	compared	compare	VERB
futech-391	159	11	to	to	ADP
futech-391	159	12	specificity	specificity	NOUN
futech-391	159	13	,	,	PUNCT
futech-391	159	14	while	while	SCONJ
futech-391	159	15	random	random	ADJ
futech-391	159	16	forest	forest	NOUN
futech-391	159	17	maintained	maintain	VERB
futech-391	159	18	moderate	moderate	ADJ
futech-391	159	19	but	but	CCONJ
futech-391	159	20	consistent	consistent	ADJ
futech-391	159	21	performance	performance	NOUN
futech-391	159	22	across	across	ADP
futech-391	159	23	all	all	DET
futech-391	159	24	metrics	metric	NOUN
futech-391	159	25	.	.	PUNCT
futech-391	160	1	support	support	NOUN
futech-391	160	2	vector	vector	NOUN
futech-391	160	3	machine	machine	NOUN
futech-391	160	4	exhibited	exhibit	VERB
futech-391	160	5	the	the	DET
futech-391	160	6	smallest	small	ADJ
futech-391	160	7	coverage	coverage	NOUN
futech-391	160	8	area	area	NOUN
futech-391	160	9	,	,	PUNCT
futech-391	160	10	reflecting	reflect	VERB
futech-391	160	11	its	its	PRON
futech-391	160	12	relatively	relatively	ADV
futech-391	160	13	conservative	conservative	ADJ
futech-391	160	14	classification	classification	NOUN
futech-391	160	15	approach	approach	NOUN
futech-391	160	16	.	.	PUNCT
futech-391	161	1	this	this	DET
futech-391	161	2	analysis	analysis	NOUN
futech-391	161	3	confirmed	confirm	VERB
futech-391	161	4	that	that	SCONJ
futech-391	161	5	the	the	DET
futech-391	161	6	ensemble	ensemble	ADJ
futech-391	161	7	methodology	methodology	NOUN
futech-391	161	8	effectively	effectively	ADV
futech-391	161	9	leveraged	leverage	VERB
futech-391	161	10	the	the	DET
futech-391	161	11	complementary	complementary	ADJ
futech-391	161	12	strengths	strength	NOUN
futech-391	161	13	of	of	ADP
futech-391	161	14	individual	individual	ADJ
futech-391	161	15	algorithms	algorithm	NOUN
futech-391	161	16	,	,	PUNCT
futech-391	161	17	resulting	result	VERB
futech-391	161	18	in	in	ADP
futech-391	161	19	enhanced	enhanced	ADJ
futech-391	161	20	predictive	predictive	ADJ
futech-391	161	21	capability	capability	NOUN
futech-391	161	22	that	that	PRON
futech-391	161	23	surpassed	surpass	VERB
futech-391	161	24	the	the	DET
futech-391	161	25	performance	performance	NOUN
futech-391	161	26	of	of	ADP
futech-391	161	27	any	any	DET
futech-391	161	28	single	single	ADJ
futech-391	161	29	machine	machine	NOUN
futech-391	161	30	learning	learn	VERB
futech-391	161	31	approach	approach	NOUN
futech-391	161	32	for	for	ADP
futech-391	161	33	diabetic	diabetic	ADJ
futech-391	161	34	nephropathy	nephropathy	NOUN
futech-391	161	35	biomarker	biomarker	NOUN
futech-391	161	36	identification	identification	NOUN
futech-391	161	37	.	.	PUNCT
futech-391	162	1	figure	figure	NOUN
futech-391	162	2	3	3	NUM
futech-391	162	3	.	.	PUNCT
futech-391	162	4	machine	machine	NOUN
futech-391	162	5	learning	learning	NOUN
futech-391	162	6	model	model	NOUN
futech-391	162	7	performance	performance	NOUN
futech-391	162	8	comparison	comparison	NOUN
futech-391	162	9	(	(	PUNCT
futech-391	162	10	a	a	NOUN
futech-391	162	11	)	)	PUNCT
futech-391	162	12	roc	roc	PROPN
futech-391	162	13	curves	curve	NOUN
futech-391	162	14	,	,	PUNCT
futech-391	162	15	(	(	PUNCT
futech-391	162	16	b	b	X
futech-391	162	17	)	)	PUNCT
futech-391	162	18	performance	performance	NOUN
futech-391	162	19	metric	metric	VERB
futech-391	162	20	the	the	DET
futech-391	162	21	feature	feature	NOUN
futech-391	162	22	importance	importance	NOUN
futech-391	162	23	analysis	analysis	NOUN
futech-391	162	24	revealed	reveal	VERB
futech-391	162	25	distinct	distinct	ADJ
futech-391	162	26	patterns	pattern	NOUN
futech-391	162	27	in	in	ADP
futech-391	162	28	biomarker	biomarker	NOUN
futech-391	162	29	prioritization	prioritization	NOUN
futech-391	162	30	across	across	ADP
futech-391	162	31	the	the	DET
futech-391	162	32	implemented	implement	VERB
futech-391	162	33	machine	machine	NOUN
futech-391	162	34	learning	learning	NOUN
futech-391	162	35	algorithms	algorithm	NOUN
futech-391	162	36	,	,	PUNCT
futech-391	162	37	as	as	SCONJ
futech-391	162	38	demonstrated	demonstrate	VERB
futech-391	162	39	in	in	ADP
futech-391	162	40	figure	figure	NOUN
futech-391	162	41	4(a	4(a	NUM
futech-391	162	42	)	)	PUNCT
futech-391	162	43	.	.	PUNCT
futech-391	163	1	kim-1	kim-1	X
futech-391	163	2	emerged	emerge	VERB
futech-391	163	3	as	as	ADP
futech-391	163	4	the	the	DET
futech-391	163	5	most	most	ADV
futech-391	163	6	consistently	consistently	ADV
futech-391	163	7	important	important	ADJ
futech-391	163	8	feature	feature	NOUN
futech-391	163	9	,	,	PUNCT
futech-391	163	10	achieving	achieve	VERB
futech-391	163	11	the	the	DET
futech-391	163	12	highest	high	ADJ
futech-391	163	13	importance	importance	NOUN
futech-391	163	14	scores	score	NOUN
futech-391	163	15	across	across	ADP
futech-391	163	16	all	all	DET
futech-391	163	17	three	three	NUM
futech-391	163	18	algorithms	algorithm	NOUN
futech-391	163	19	with	with	ADP
futech-391	163	20	values	value	NOUN
futech-391	163	21	exceeding	exceed	VERB
futech-391	163	22	0.09	0.09	NUM
futech-391	163	23	for	for	ADP
futech-391	163	24	random	random	ADJ
futech-391	163	25	forest	forest	NOUN
futech-391	163	26	and	and	CCONJ
futech-391	163	27	xgboost	xgboost	NOUN
futech-391	163	28	implementations	implementation	NOUN
futech-391	163	29	.	.	PUNCT
futech-391	164	1	ngal	ngal	ADJ
futech-391	164	2	and	and	CCONJ
futech-391	164	3	l	l	NOUN
futech-391	164	4	-	-	NOUN
futech-391	164	5	fabp	fabp	PROPN
futech-391	164	6	demonstrated	demonstrate	VERB
futech-391	164	7	similarly	similarly	ADV
futech-391	164	8	robust	robust	ADJ
futech-391	164	9	performance	performance	NOUN
futech-391	164	10	,	,	PUNCT
futech-391	164	11	maintaining	maintain	VERB
futech-391	164	12	importance	importance	NOUN
futech-391	164	13	scores	score	NOUN
futech-391	164	14	above	above	ADP
futech-391	164	15	0.08	0.08	NUM
futech-391	164	16	across	across	ADP
futech-391	164	17	multiple	multiple	ADJ
futech-391	164	18	algorithms	algorithm	NOUN
futech-391	164	19	,	,	PUNCT
futech-391	164	20	which	which	PRON
futech-391	164	21	confirms	confirm	VERB
futech-391	164	22	their	their	PRON
futech-391	164	23	established	establish	VERB
futech-391	164	24	roles	role	NOUN
futech-391	164	25	as	as	ADP
futech-391	164	26	tubular	tubular	ADJ
futech-391	164	27	injury	injury	NOUN
futech-391	164	28	markers	marker	NOUN
futech-391	164	29	in	in	ADP
futech-391	164	30	diabetic	diabetic	ADJ
futech-391	164	31	nephropathy	nephropathy	ADJ
futech-391	164	32	progression	progression	NOUN
futech-391	164	33	.	.	PUNCT
futech-391	165	1	the	the	DET
futech-391	165	2	comprehensive	comprehensive	ADJ
futech-391	165	3	ranking	ranking	NOUN
futech-391	165	4	encompassed	encompass	VERB
futech-391	165	5	twenty	twenty	NUM
futech-391	165	6	distinct	distinct	ADJ
futech-391	165	7	molecular	molecular	ADJ
futech-391	165	8	features	feature	NOUN
futech-391	165	9	,	,	PUNCT
futech-391	165	10	including	include	VERB
futech-391	165	11	traditional	traditional	ADJ
futech-391	165	12	markers	marker	NOUN
futech-391	165	13	such	such	ADJ
futech-391	165	14	as	as	ADP
futech-391	165	15	cystatin	cystatin	PROPN
futech-391	165	16	c	c	PROPN
futech-391	165	17	and	and	CCONJ
futech-391	165	18	β	β	X
futech-391	165	19	2microglobulin	2microglobulin	NUM
futech-391	165	20	alongside	alongside	ADP
futech-391	165	21	novel	novel	ADJ
futech-391	165	22	candidates	candidate	NOUN
futech-391	165	23	like	like	ADP
futech-391	165	24	podocalyxin	podocalyxin	NOUN
futech-391	165	25	and	and	CCONJ
futech-391	165	26	nephrin	nephrin	NOUN
futech-391	165	27	,	,	PUNCT
futech-391	165	28	indicating	indicate	VERB
futech-391	165	29	the	the	DET
futech-391	165	30	multi	multi	ADJ
futech-391	165	31	-	-	ADJ
futech-391	165	32	omics	omics	ADJ
futech-391	165	33	approach	approach	NOUN
futech-391	165	34	successfully	successfully	ADV
futech-391	165	35	captured	capture	VERB
futech-391	165	36	both	both	CCONJ
futech-391	165	37	established	establish	VERB
futech-391	165	38	and	and	CCONJ
futech-391	165	39	emerging	emerge	VERB
futech-391	165	40	biomarker	biomarker	NOUN
futech-391	165	41	signatures	signature	NOUN
futech-391	165	42	.	.	PUNCT
futech-391	166	1	the	the	DET
futech-391	166	2	feature	feature	NOUN
futech-391	166	3	consistency	consistency	NOUN
futech-391	166	4	analysis	analysis	NOUN
futech-391	166	5	provided	provide	VERB
futech-391	166	6	critical	critical	ADJ
futech-391	166	7	insights	insight	NOUN
futech-391	166	8	into	into	ADP
futech-391	166	9	algorithmic	algorithmic	ADJ
futech-391	166	10	concordance	concordance	NOUN
futech-391	166	11	and	and	CCONJ
futech-391	166	12	biomarker	biomarker	NOUN
futech-391	166	13	reliability	reliability	NOUN
futech-391	166	14	,	,	PUNCT
futech-391	166	15	as	as	SCONJ
futech-391	166	16	illustrated	illustrate	VERB
futech-391	166	17	in	in	ADP
futech-391	166	18	figure	figure	NOUN
futech-391	166	19	4(b	4(b	NUM
futech-391	166	20	)	)	PUNCT
futech-391	166	21	.	.	PUNCT
futech-391	167	1	the	the	DET
futech-391	167	2	venn	venn	PROPN
futech-391	167	3	diagram	diagram	PROPN
futech-391	167	4	revealed	reveal	VERB
futech-391	167	5	that	that	SCONJ
futech-391	167	6	twelve	twelve	NUM
futech-391	167	7	features	feature	NOUN
futech-391	167	8	were	be	AUX
futech-391	167	9	uniquely	uniquely	ADV
futech-391	167	10	identified	identify	VERB
futech-391	167	11	by	by	ADP
futech-391	167	12	random	random	ADJ
futech-391	167	13	forest	forest	NOUN
futech-391	167	14	,	,	PUNCT
futech-391	167	15	while	while	SCONJ
futech-391	167	16	support	support	NOUN
futech-391	167	17	vector	vector	NOUN
futech-391	167	18	machine	machine	NOUN
futech-391	167	19	and	and	CCONJ
futech-391	167	20	xgboost	xgboost	NOUN
futech-391	167	21	contributed	contribute	VERB
futech-391	167	22	eight	eight	NUM
futech-391	167	23	and	and	CCONJ
futech-391	167	24	fifteen	fifteen	NUM
futech-391	167	25	algorithm	algorithm	NOUN
futech-391	167	26	-	-	PUNCT
futech-391	167	27	specific	specific	ADJ
futech-391	167	28	features	feature	NOUN
futech-391	167	29	,	,	PUNCT
futech-391	167	30	respectively	respectively	ADV
futech-391	167	31	.	.	PUNCT
futech-391	168	1	notably	notably	ADV
futech-391	168	2	,	,	PUNCT
futech-391	168	3	only	only	ADV
futech-391	168	4	two	two	NUM
futech-391	168	5	features	feature	NOUN
futech-391	168	6	demonstrated	demonstrate	VERB
futech-391	168	7	complete	complete	ADJ
futech-391	168	8	agreement	agreement	NOUN
futech-391	168	9	across	across	ADP
futech-391	168	10	all	all	DET
futech-391	168	11	three	three	NUM
futech-391	168	12	algorithms	algorithm	NOUN
futech-391	168	13	,	,	PUNCT
futech-391	168	14	while	while	SCONJ
futech-391	168	15	four	four	NUM
futech-391	168	16	features	feature	NOUN
futech-391	168	17	showed	show	VERB
futech-391	168	18	concordance	concordance	NOUN
futech-391	168	19	between	between	ADP
futech-391	168	20	random	random	ADJ
futech-391	168	21	forest	forest	NOUN
futech-391	168	22	and	and	CCONJ
futech-391	168	23	xgboost	xgboost	ADV
futech-391	168	24	,	,	PUNCT
futech-391	168	25	and	and	CCONJ
futech-391	168	26	three	three	NUM
futech-391	168	27	features	feature	NOUN
futech-391	168	28	were	be	AUX
futech-391	168	29	shared	share	VERB
futech-391	168	30	between	between	ADP
futech-391	168	31	support	support	NOUN
futech-391	168	32	vector	vector	NOUN
futech-391	168	33	machine	machine	NOUN
futech-391	168	34	and	and	CCONJ
futech-391	168	35	xgboost	xgboost	NOUN
futech-391	168	36	.	.	PUNCT
futech-391	169	1	this	this	DET
futech-391	169	2	analysis	analysis	NOUN
futech-391	169	3	underscores	underscore	VERB
futech-391	169	4	the	the	DET
futech-391	169	5	complementary	complementary	ADJ
futech-391	169	6	nature	nature	NOUN
futech-391	169	7	of	of	ADP
futech-391	169	8	different	different	ADJ
futech-391	169	9	machine	machine	NOUN
futech-391	169	10	learning	learn	VERB
futech-391	169	11	approaches	approach	NOUN
futech-391	169	12	in	in	ADP
futech-391	169	13	biomarker	biomarker	NOUN
futech-391	169	14	discovery	discovery	NOUN
futech-391	169	15	,	,	PUNCT
futech-391	169	16	with	with	ADP
futech-391	169	17	each	each	DET
futech-391	169	18	algorithm	algorithm	NOUN
futech-391	169	19	contributing	contribute	VERB
futech-391	169	20	unique	unique	ADJ
futech-391	169	21	perspectives	perspective	NOUN
futech-391	169	22	on	on	ADP
futech-391	169	23	feature	feature	NOUN
futech-391	169	24	relevance	relevance	NOUN
futech-391	169	25	that	that	PRON
futech-391	169	26	collectively	collectively	ADV
futech-391	169	27	enhance	enhance	VERB
futech-391	169	28	the	the	DET
futech-391	169	29	robustness	robustness	NOUN
futech-391	169	30	of	of	ADP
futech-391	169	31	biomarker	biomarker	NOUN
futech-391	169	32	identification	identification	NOUN
futech-391	169	33	.	.	PUNCT
futech-391	170	1	the	the	DET
futech-391	170	2	shap	shap	PROPN
futech-391	170	3	value	value	NOUN
futech-391	170	4	analysis	analysis	NOUN
futech-391	170	5	elucidated	elucidate	VERB
futech-391	170	6	the	the	DET
futech-391	170	7	directional	directional	ADJ
futech-391	170	8	contributions	contribution	NOUN
futech-391	170	9	of	of	ADP
futech-391	170	10	individual	individual	ADJ
futech-391	170	11	biomarkers	biomarker	NOUN
futech-391	170	12	to	to	ADP
futech-391	170	13	diabetic	diabetic	ADJ
futech-391	170	14	nephropathy	nephropathy	ADJ
futech-391	170	15	classification	classification	NOUN
futech-391	170	16	,	,	PUNCT
futech-391	170	17	as	as	SCONJ
futech-391	170	18	shown	show	VERB
futech-391	170	19	in	in	ADP
futech-391	170	20	figure	figure	NOUN
futech-391	170	21	4(c	4(c	NUM
futech-391	170	22	)	)	PUNCT
futech-391	170	23	.	.	PUNCT
futech-391	171	1	kim-1	kim-1	X
futech-391	171	2	,	,	PUNCT
futech-391	171	3	ngal	ngal	ADJ
futech-391	171	4	,	,	PUNCT
futech-391	171	5	and	and	CCONJ
futech-391	171	6	l	l	NOUN
futech-391	171	7	-	-	ADJ
futech-391	171	8	fabp	fabp	PROPN
futech-391	171	9	exhibited	exhibit	VERB
futech-391	171	10	predominantly	predominantly	ADV
futech-391	171	11	positive	positive	ADJ
futech-391	171	12	impacts	impact	NOUN
futech-391	171	13	on	on	ADP
futech-391	171	14	disease	disease	NOUN
futech-391	171	15	prediction	prediction	NOUN
futech-391	171	16	,	,	PUNCT
futech-391	171	17	with	with	ADP
futech-391	171	18	shap	shap	PROPN
futech-391	171	19	values	value	NOUN
futech-391	171	20	extending	extend	VERB
futech-391	171	21	beyond	beyond	ADP
futech-391	171	22	0.06	0.06	NUM
futech-391	171	23	,	,	PUNCT
futech-391	171	24	consistent	consistent	ADJ
futech-391	171	25	with	with	ADP
futech-391	171	26	their	their	PRON
futech-391	171	27	established	establish	VERB
futech-391	171	28	roles	role	NOUN
futech-391	171	29	as	as	ADP
futech-391	171	30	damage	damage	NOUN
futech-391	171	31	-	-	PUNCT
futech-391	171	32	associated	associate	VERB
futech-391	171	33	molecular	molecular	ADJ
futech-391	171	34	patterns	pattern	NOUN
futech-391	171	35	in	in	ADP
futech-391	171	36	tubular	tubular	ADJ
futech-391	171	37	epithelial	epithelial	ADJ
futech-391	171	38	cell	cell	NOUN
futech-391	171	39	injury	injury	NOUN
futech-391	171	40	.	.	PUNCT
futech-391	172	1	w.	w.	PROPN
futech-391	172	2	li	li	PROPN
futech-391	172	3	&	&	CCONJ
futech-391	172	4	sp	sp	PROPN
futech-391	172	5	.	.	PROPN
futech-391	172	6	chandran	chandran	PROPN
futech-391	172	7	/future	/future	PUNCT
futech-391	172	8	technology	technology	PROPN
futech-391	172	9	august	august	PROPN
futech-391	172	10	2025|	2025|	NUM
futech-391	172	11	volume	volume	NOUN
futech-391	172	12	04	04	NUM
futech-391	173	1	|	|	NOUN
futech-391	173	2	issue	issue	NOUN
futech-391	173	3	03	03	NUM
futech-391	174	1	|	|	ADV
futech-391	174	2	pages	page	NOUN
futech-391	174	3	193	193	NUM
futech-391	174	4	-	-	SYM
futech-391	174	5	203	203	NUM
futech-391	174	6	198	198	NUM
futech-391	174	7	conversely	conversely	ADV
futech-391	174	8	,	,	PUNCT
futech-391	174	9	egfr	egfr	NOUN
futech-391	174	10	and	and	CCONJ
futech-391	174	11	acr	acr	PROPN
futech-391	174	12	demonstrated	demonstrate	VERB
futech-391	174	13	negative	negative	ADJ
futech-391	174	14	contributions	contribution	NOUN
futech-391	174	15	,	,	PUNCT
futech-391	174	16	reflecting	reflect	VERB
futech-391	174	17	their	their	PRON
futech-391	174	18	inverse	inverse	NOUN
futech-391	174	19	relationship	relationship	NOUN
futech-391	174	20	with	with	ADP
futech-391	174	21	disease	disease	NOUN
futech-391	174	22	severity	severity	NOUN
futech-391	174	23	and	and	CCONJ
futech-391	174	24	supporting	support	VERB
futech-391	174	25	their	their	PRON
futech-391	174	26	clinical	clinical	ADJ
futech-391	174	27	utility	utility	NOUN
futech-391	174	28	as	as	ADP
futech-391	174	29	protective	protective	ADJ
futech-391	174	30	indicators	indicator	NOUN
futech-391	174	31	.	.	PUNCT
futech-391	175	1	the	the	DET
futech-391	175	2	bidirectional	bidirectional	ADJ
futech-391	175	3	shap	shap	PROPN
futech-391	175	4	value	value	NOUN
futech-391	175	5	distribution	distribution	NOUN
futech-391	175	6	revealed	reveal	VERB
futech-391	175	7	complex	complex	ADJ
futech-391	175	8	biomarker	biomarker	NOUN
futech-391	175	9	interactions	interaction	NOUN
futech-391	175	10	,	,	PUNCT
futech-391	175	11	with	with	ADP
futech-391	175	12	some	some	DET
futech-391	175	13	features	feature	NOUN
futech-391	175	14	displaying	display	VERB
futech-391	175	15	context	context	NOUN
futech-391	175	16	-	-	PUNCT
futech-391	175	17	dependent	dependent	ADJ
futech-391	175	18	effects	effect	NOUN
futech-391	175	19	that	that	PRON
futech-391	175	20	highlight	highlight	VERB
futech-391	175	21	the	the	DET
futech-391	175	22	sophisticated	sophisticated	ADJ
futech-391	175	23	decision	decision	NOUN
futech-391	175	24	-	-	PUNCT
futech-391	175	25	making	make	VERB
futech-391	175	26	processes	process	NOUN
futech-391	175	27	employed	employ	VERB
futech-391	175	28	by	by	ADP
futech-391	175	29	the	the	DET
futech-391	175	30	ensemble	ensemble	ADJ
futech-391	175	31	learning	learning	NOUN
futech-391	175	32	framework	framework	NOUN
futech-391	175	33	.	.	PUNCT
futech-391	176	1	the	the	DET
futech-391	176	2	correlation	correlation	NOUN
futech-391	176	3	heatmap	heatmap	NOUN
futech-391	176	4	analysis	analysis	NOUN
futech-391	176	5	revealed	reveal	VERB
futech-391	176	6	intricate	intricate	ADJ
futech-391	176	7	interdependencies	interdependency	NOUN
futech-391	176	8	among	among	ADP
futech-391	176	9	identified	identify	VERB
futech-391	176	10	biomarkers	biomarker	NOUN
futech-391	176	11	,	,	PUNCT
futech-391	176	12	as	as	SCONJ
futech-391	176	13	depicted	depict	VERB
futech-391	176	14	in	in	ADP
futech-391	176	15	figure	figure	NOUN
futech-391	176	16	4(d	4(d	NUM
futech-391	176	17	)	)	PUNCT
futech-391	176	18	.	.	PUNCT
futech-391	177	1	strong	strong	ADJ
futech-391	177	2	positive	positive	ADJ
futech-391	177	3	correlations	correlation	NOUN
futech-391	177	4	were	be	AUX
futech-391	177	5	observed	observe	VERB
futech-391	177	6	between	between	ADP
futech-391	177	7	kim-1	kim-1	NUM
futech-391	177	8	and	and	CCONJ
futech-391	177	9	ngal	ngal	ADJ
futech-391	177	10	(	(	PUNCT
futech-391	177	11	r=0.85	r=0.85	NOUN
futech-391	177	12	)	)	PUNCT
futech-391	177	13	,	,	PUNCT
futech-391	177	14	as	as	ADV
futech-391	177	15	well	well	ADV
futech-391	177	16	as	as	ADP
futech-391	177	17	between	between	ADP
futech-391	177	18	lfabp	lfabp	NOUN
futech-391	177	19	and	and	CCONJ
futech-391	177	20	cystatin	cystatin	PROPN
futech-391	177	21	c	c	PROPN
futech-391	177	22	(	(	PUNCT
futech-391	177	23	r=0.79	r=0.79	PROPN
futech-391	177	24	)	)	PUNCT
futech-391	177	25	,	,	PUNCT
futech-391	177	26	suggesting	suggest	VERB
futech-391	177	27	coordinated	coordinate	VERB
futech-391	177	28	expression	expression	NOUN
futech-391	177	29	patterns	pattern	NOUN
futech-391	177	30	during	during	ADP
futech-391	177	31	tubular	tubular	ADJ
futech-391	177	32	epithelial	epithelial	ADJ
futech-391	177	33	cell	cell	NOUN
futech-391	177	34	stress	stress	NOUN
futech-391	177	35	responses	response	NOUN
futech-391	177	36	.	.	PUNCT
futech-391	178	1	conversely	conversely	ADV
futech-391	178	2	,	,	PUNCT
futech-391	178	3	negative	negative	ADJ
futech-391	178	4	correlations	correlation	NOUN
futech-391	178	5	between	between	ADP
futech-391	178	6	egfr	egfr	NOUN
futech-391	178	7	and	and	CCONJ
futech-391	178	8	multiple	multiple	ADJ
futech-391	178	9	tubular	tubular	ADJ
futech-391	178	10	injury	injury	NOUN
futech-391	178	11	markers	marker	NOUN
futech-391	178	12	,	,	PUNCT
futech-391	178	13	including	include	VERB
futech-391	178	14	kim-1	kim-1	X
futech-391	178	15	(	(	PUNCT
futech-391	178	16	r=0.52	r=0.52	NOUN
futech-391	178	17	)	)	PUNCT
futech-391	178	18	and	and	CCONJ
futech-391	178	19	ngal	ngal	ADJ
futech-391	178	20	(	(	PUNCT
futech-391	178	21	r=-0.48	r=-0.48	PROPN
futech-391	178	22	)	)	PUNCT
futech-391	178	23	,	,	PUNCT
futech-391	178	24	confirmed	confirm	VERB
futech-391	178	25	the	the	DET
futech-391	178	26	expected	expect	VERB
futech-391	178	27	inverse	inverse	NOUN
futech-391	178	28	relationship	relationship	NOUN
futech-391	178	29	between	between	ADP
futech-391	178	30	kidney	kidney	NOUN
futech-391	178	31	function	function	NOUN
futech-391	178	32	and	and	CCONJ
futech-391	178	33	cellular	cellular	ADJ
futech-391	178	34	damage	damage	NOUN
futech-391	178	35	indicators	indicator	NOUN
futech-391	178	36	.	.	PUNCT
futech-391	179	1	these	these	DET
futech-391	179	2	correlation	correlation	NOUN
futech-391	179	3	patterns	pattern	NOUN
futech-391	179	4	validate	validate	VERB
futech-391	179	5	the	the	DET
futech-391	179	6	biological	biological	ADJ
futech-391	179	7	plausibility	plausibility	NOUN
futech-391	179	8	of	of	ADP
futech-391	179	9	identified	identify	VERB
futech-391	179	10	biomarker	biomarker	NOUN
futech-391	179	11	combinations	combination	NOUN
futech-391	179	12	and	and	CCONJ
futech-391	179	13	support	support	VERB
futech-391	179	14	the	the	DET
futech-391	179	15	mechanistic	mechanistic	ADJ
futech-391	179	16	relevance	relevance	NOUN
futech-391	179	17	of	of	ADP
futech-391	179	18	the	the	DET
futech-391	179	19	machine	machine	NOUN
futech-391	179	20	learning	learning	NOUN
futech-391	179	21	-	-	PUNCT
futech-391	179	22	derived	derive	VERB
futech-391	179	23	feature	feature	NOUN
futech-391	179	24	importance	importance	NOUN
futech-391	179	25	rankings	ranking	NOUN
futech-391	179	26	for	for	ADP
futech-391	179	27	tubular	tubular	ADJ
futech-391	179	28	epithelial	epithelial	ADJ
futech-391	179	29	cellspecific	cellspecific	NOUN
futech-391	179	30	diabetic	diabetic	ADJ
futech-391	179	31	nephropathy	nephropathy	NOUN
futech-391	179	32	biomarker	biomarker	NOUN
futech-391	179	33	development	development	NOUN
futech-391	179	34	.	.	PUNCT
futech-391	180	1	3.3	3.3	NUM
futech-391	180	2	candidate	candidate	NOUN
futech-391	180	3	biomarker	biomarker	NOUN
futech-391	180	4	identification	identification	NOUN
futech-391	180	5	results	result	VERB
futech-391	180	6	the	the	DET
futech-391	180	7	machine	machine	NOUN
futech-391	180	8	learning	learning	NOUN
futech-391	180	9	-	-	PUNCT
futech-391	180	10	based	base	VERB
futech-391	180	11	multi	multi	ADJ
futech-391	180	12	-	-	ADJ
futech-391	180	13	omics	omics	ADJ
futech-391	180	14	integration	integration	NOUN
futech-391	180	15	successfully	successfully	ADV
futech-391	180	16	identified	identify	VERB
futech-391	180	17	ten	ten	NUM
futech-391	180	18	tubular	tubular	ADJ
futech-391	180	19	epithelial	epithelial	ADJ
futech-391	180	20	cell	cell	NOUN
futech-391	180	21	-	-	PUNCT
futech-391	180	22	specific	specific	ADJ
futech-391	180	23	candidate	candidate	NOUN
futech-391	180	24	biomarkers	biomarker	NOUN
futech-391	180	25	demonstrating	demonstrate	VERB
futech-391	180	26	significant	significant	ADJ
futech-391	180	27	differential	differential	ADJ
futech-391	180	28	expression	expression	NOUN
futech-391	180	29	in	in	ADP
futech-391	180	30	diabetic	diabetic	ADJ
futech-391	180	31	nephropathy	nephropathy	NOUN
futech-391	180	32	,	,	PUNCT
futech-391	180	33	as	as	SCONJ
futech-391	180	34	shown	show	VERB
futech-391	180	35	in	in	ADP
futech-391	180	36	table	table	NOUN
futech-391	180	37	3	3	NUM
futech-391	180	38	.	.	PUNCT
futech-391	181	1	kim1	kim1	PROPN
futech-391	181	2	emerged	emerge	VERB
futech-391	181	3	as	as	ADP
futech-391	181	4	the	the	DET
futech-391	181	5	highest	highest	ADV
futech-391	181	6	-	-	PUNCT
futech-391	181	7	ranked	rank	VERB
futech-391	181	8	biomarker	biomarker	NOUN
futech-391	181	9	with	with	ADP
futech-391	181	10	an	an	DET
futech-391	181	11	importance	importance	NOUN
futech-391	181	12	score	score	NOUN
futech-391	181	13	of	of	ADP
futech-391	181	14	0.092	0.092	NUM
futech-391	181	15	and	and	CCONJ
futech-391	181	16	a	a	DET
futech-391	181	17	3.2	3.2	NUM
futech-391	181	18	-	-	ADJ
futech-391	181	19	fold	fold	ADJ
futech-391	181	20	upregulation	upregulation	NOUN
futech-391	181	21	,	,	PUNCT
futech-391	181	22	followed	follow	VERB
futech-391	181	23	by	by	ADP
futech-391	181	24	ngal	ngal	ADJ
futech-391	181	25	and	and	CCONJ
futech-391	181	26	l	l	NOUN
futech-391	181	27	-	-	NOUN
futech-391	181	28	fabp	fabp	VERB
futech-391	181	29	with	with	ADP
futech-391	181	30	importance	importance	NOUN
futech-391	181	31	scores	score	NOUN
futech-391	181	32	of	of	ADP
futech-391	181	33	0.087	0.087	NUM
futech-391	181	34	and	and	CCONJ
futech-391	181	35	0.084	0.084	NUM
futech-391	181	36	,	,	PUNCT
futech-391	181	37	respectively	respectively	ADV
futech-391	181	38	.	.	PUNCT
futech-391	182	1	these	these	DET
futech-391	182	2	top	top	ADV
futech-391	182	3	-	-	PUNCT
futech-391	182	4	ranked	rank	VERB
futech-391	182	5	markers	marker	NOUN
futech-391	182	6	exhibited	exhibit	VERB
futech-391	182	7	robust	robust	ADJ
futech-391	182	8	individual	individual	ADJ
futech-391	182	9	diagnostic	diagnostic	ADJ
futech-391	182	10	performance	performance	NOUN
futech-391	182	11	with	with	ADP
futech-391	182	12	auc	auc	NOUN
futech-391	182	13	values	value	NOUN
futech-391	182	14	exceeding	exceed	VERB
futech-391	182	15	0.86	0.86	NUM
futech-391	182	16	,	,	PUNCT
futech-391	182	17	substantially	substantially	ADV
futech-391	182	18	surpassing	surpass	VERB
futech-391	182	19	conventional	conventional	ADJ
futech-391	182	20	clinical	clinical	ADJ
futech-391	182	21	indicators	indicator	NOUN
futech-391	182	22	.	.	PUNCT
futech-391	183	1	the	the	DET
futech-391	183	2	identified	identify	VERB
futech-391	183	3	biomarkers	biomarker	NOUN
futech-391	183	4	encompassed	encompass	VERB
futech-391	183	5	diverse	diverse	ADJ
futech-391	183	6	functional	functional	ADJ
futech-391	183	7	categories	category	NOUN
futech-391	183	8	,	,	PUNCT
futech-391	183	9	including	include	VERB
futech-391	183	10	acute	acute	ADJ
futech-391	183	11	injury	injury	NOUN
futech-391	183	12	markers	marker	NOUN
futech-391	183	13	,	,	PUNCT
futech-391	183	14	inflammatory	inflammatory	ADJ
futech-391	183	15	mediators	mediator	NOUN
futech-391	183	16	,	,	PUNCT
futech-391	183	17	and	and	CCONJ
futech-391	183	18	metabolic	metabolic	ADJ
futech-391	183	19	dysfunction	dysfunction	NOUN
futech-391	183	20	indicators	indicator	NOUN
futech-391	183	21	,	,	PUNCT
futech-391	183	22	reflecting	reflect	VERB
futech-391	183	23	the	the	DET
futech-391	183	24	multifaceted	multifaceted	ADJ
futech-391	183	25	pathophysiology	pathophysiology	NOUN
futech-391	183	26	of	of	ADP
futech-391	183	27	tubular	tubular	ADJ
futech-391	183	28	damage	damage	NOUN
futech-391	183	29	in	in	ADP
futech-391	183	30	diabetic	diabetic	ADJ
futech-391	183	31	nephropathy	nephropathy	NOUN
futech-391	183	32	.	.	PUNCT
futech-391	184	1	the	the	DET
futech-391	184	2	comprehensive	comprehensive	ADJ
futech-391	184	3	biomarker	biomarker	NOUN
futech-391	184	4	panel	panel	NOUN
futech-391	184	5	revealed	reveal	VERB
futech-391	184	6	distinct	distinct	ADJ
futech-391	184	7	molecular	molecular	ADJ
futech-391	184	8	signatures	signature	NOUN
futech-391	184	9	associated	associate	VERB
futech-391	184	10	with	with	ADP
futech-391	184	11	tubular	tubular	ADJ
futech-391	184	12	epithelial	epithelial	ADJ
futech-391	184	13	cell	cell	NOUN
futech-391	184	14	dysfunction	dysfunction	NOUN
futech-391	184	15	,	,	PUNCT
futech-391	184	16	with	with	ADP
futech-391	184	17	nine	nine	NUM
futech-391	184	18	of	of	ADP
futech-391	184	19	ten	ten	NUM
futech-391	184	20	candidates	candidate	NOUN
futech-391	184	21	showing	show	VERB
futech-391	184	22	significant	significant	ADJ
futech-391	184	23	upregulation	upregulation	NOUN
futech-391	184	24	ranging	range	VERB
futech-391	184	25	from	from	ADP
futech-391	184	26	1.6	1.6	NUM
futech-391	184	27	to	to	PART
futech-391	184	28	3.2	3.2	NUM
futech-391	184	29	-	-	NUM
futech-391	184	30	fold	fold	ADV
futech-391	184	31	.	.	PUNCT
futech-391	185	1	notably	notably	ADV
futech-391	185	2	,	,	PUNCT
futech-391	185	3	nephrin	nephrin	PROPN
futech-391	185	4	demonstrated	demonstrate	VERB
futech-391	185	5	unique	unique	ADJ
futech-391	185	6	downregulation	downregulation	NOUN
futech-391	185	7	patterns	pattern	NOUN
futech-391	185	8	,	,	PUNCT
futech-391	185	9	suggesting	suggest	VERB
futech-391	185	10	compromised	compromise	VERB
futech-391	185	11	barrier	barrier	NOUN
futech-391	185	12	function	function	NOUN
futech-391	185	13	in	in	ADP
futech-391	185	14	diseased	diseased	ADJ
futech-391	185	15	tubules	tubule	NOUN
futech-391	185	16	.	.	PUNCT
futech-391	186	1	statistical	statistical	ADJ
futech-391	186	2	significance	significance	NOUN
futech-391	186	3	remained	remain	VERB
futech-391	186	4	robust	robust	ADJ
futech-391	186	5	across	across	ADP
futech-391	186	6	all	all	DET
futech-391	186	7	candidates	candidate	NOUN
futech-391	186	8	after	after	ADP
futech-391	186	9	fdr	fdr	PROPN
futech-391	186	10	correction	correction	NOUN
futech-391	186	11	,	,	PUNCT
futech-391	186	12	with	with	ADP
futech-391	186	13	pvalues	pvalue	NOUN
futech-391	186	14	below	below	ADP
futech-391	186	15	0.011	0.011	NUM
futech-391	186	16	.	.	PUNCT
futech-391	187	1	figure	figure	NOUN
futech-391	187	2	4	4	NUM
futech-391	187	3	.	.	PUNCT
futech-391	187	4	feature	feature	NOUN
futech-391	187	5	importance	importance	NOUN
futech-391	187	6	and	and	CCONJ
futech-391	187	7	model	model	NOUN
futech-391	187	8	interpretation	interpretation	NOUN
futech-391	187	9	analysis	analysis	NOUN
futech-391	187	10	(	(	PUNCT
futech-391	187	11	a	a	X
futech-391	187	12	)	)	PUNCT
futech-391	187	13	feature	feature	NOUN
futech-391	187	14	importance	importance	NOUN
futech-391	187	15	ranking	ranking	NOUN
futech-391	187	16	,	,	PUNCT
futech-391	187	17	(	(	PUNCT
futech-391	187	18	b	b	X
futech-391	187	19	)	)	PUNCT
futech-391	187	20	feature	feature	NOUN
futech-391	187	21	consistency	consistency	NOUN
futech-391	187	22	analysis	analysis	NOUN
futech-391	187	23	,	,	PUNCT
futech-391	187	24	(	(	PUNCT
futech-391	187	25	c	c	X
futech-391	187	26	)	)	PUNCT
futech-391	187	27	shap	shap	NOUN
futech-391	187	28	value	value	NOUN
futech-391	187	29	analysis	analysis	NOUN
futech-391	187	30	,	,	PUNCT
futech-391	187	31	(	(	PUNCT
futech-391	187	32	d	d	X
futech-391	187	33	)	)	PUNCT
futech-391	187	34	feature	feature	NOUN
futech-391	187	35	correlation	correlation	NOUN
futech-391	187	36	heatmap	heatmap	NOUN
futech-391	187	37	w.	w.	PROPN
futech-391	187	38	li	li	PROPN
futech-391	187	39	&	&	CCONJ
futech-391	187	40	sp	sp	PROPN
futech-391	187	41	.	.	PROPN
futech-391	187	42	chandran	chandran	PROPN
futech-391	187	43	/future	/future	PUNCT
futech-391	187	44	technology	technology	PROPN
futech-391	187	45	august	august	PROPN
futech-391	187	46	2025|	2025|	NUM
futech-391	187	47	volume	volume	NOUN
futech-391	187	48	04	04	NUM
futech-391	188	1	|	|	NOUN
futech-391	188	2	issue	issue	NOUN
futech-391	188	3	03	03	NUM
futech-391	189	1	|	|	ADV
futech-391	189	2	pages	page	NOUN
futech-391	189	3	193	193	NUM
futech-391	189	4	-	-	SYM
futech-391	189	5	203	203	NUM
futech-391	189	6	199	199	NUM
futech-391	189	7	the	the	DET
futech-391	189	8	functional	functional	ADJ
futech-391	189	9	diversity	diversity	NOUN
futech-391	189	10	of	of	ADP
futech-391	189	11	identified	identify	VERB
futech-391	189	12	biomarkers	biomarker	NOUN
futech-391	189	13	,	,	PUNCT
futech-391	189	14	spanning	span	VERB
futech-391	189	15	from	from	ADP
futech-391	189	16	lipid	lipid	ADJ
futech-391	189	17	metabolism	metabolism	NOUN
futech-391	189	18	alterations	alteration	NOUN
futech-391	189	19	to	to	ADP
futech-391	189	20	fibrosis	fibrosis	NOUN
futech-391	189	21	progression	progression	NOUN
futech-391	189	22	markers	marker	NOUN
futech-391	189	23	,	,	PUNCT
futech-391	189	24	provides	provide	VERB
futech-391	189	25	mechanistic	mechanistic	ADJ
futech-391	189	26	insights	insight	NOUN
futech-391	189	27	into	into	ADP
futech-391	189	28	tubular	tubular	ADJ
futech-391	189	29	pathology	pathology	NOUN
futech-391	189	30	while	while	SCONJ
futech-391	189	31	offering	offer	VERB
futech-391	189	32	potential	potential	ADJ
futech-391	189	33	targets	target	NOUN
futech-391	189	34	for	for	ADP
futech-391	189	35	therapeutic	therapeutic	ADJ
futech-391	189	36	intervention	intervention	NOUN
futech-391	189	37	and	and	CCONJ
futech-391	189	38	disease	disease	NOUN
futech-391	189	39	monitoring	monitoring	NOUN
futech-391	189	40	in	in	ADP
futech-391	189	41	clinical	clinical	ADJ
futech-391	189	42	practice	practice	NOUN
futech-391	189	43	.	.	PUNCT
futech-391	190	1	the	the	DET
futech-391	190	2	expression	expression	NOUN
futech-391	190	3	pattern	pattern	NOUN
futech-391	190	4	analysis	analysis	NOUN
futech-391	190	5	across	across	ADP
futech-391	190	6	different	different	ADJ
futech-391	190	7	disease	disease	NOUN
futech-391	190	8	stages	stage	NOUN
futech-391	190	9	demonstrated	demonstrate	VERB
futech-391	190	10	progressive	progressive	ADJ
futech-391	190	11	molecular	molecular	ADJ
futech-391	190	12	alterations	alteration	NOUN
futech-391	190	13	in	in	ADP
futech-391	190	14	tubular	tubular	ADJ
futech-391	190	15	epithelial	epithelial	ADJ
futech-391	190	16	cells	cell	NOUN
futech-391	190	17	,	,	PUNCT
futech-391	190	18	as	as	SCONJ
futech-391	190	19	illustrated	illustrate	VERB
futech-391	190	20	in	in	ADP
futech-391	190	21	figure	figure	NOUN
futech-391	190	22	5(a	5(a	NUM
futech-391	190	23	)	)	PUNCT
futech-391	190	24	.	.	PUNCT
futech-391	191	1	the	the	DET
futech-391	191	2	study	study	NOUN
futech-391	191	3	revealed	reveal	VERB
futech-391	191	4	distinct	distinct	ADJ
futech-391	191	5	biomarker	biomarker	NOUN
futech-391	191	6	expression	expression	NOUN
futech-391	191	7	trajectories	trajectory	NOUN
futech-391	191	8	that	that	PRON
futech-391	191	9	correlated	correlate	VERB
futech-391	191	10	with	with	ADP
futech-391	191	11	disease	disease	NOUN
futech-391	191	12	severity	severity	NOUN
futech-391	191	13	,	,	PUNCT
futech-391	191	14	where	where	SCONJ
futech-391	191	15	kim1	kim1	PROPN
futech-391	191	16	,	,	PUNCT
futech-391	191	17	ngal	ngal	ADJ
futech-391	191	18	,	,	PUNCT
futech-391	191	19	and	and	CCONJ
futech-391	191	20	l	l	NOUN
futech-391	191	21	-	-	ADJ
futech-391	191	22	fabp	fabp	PROPN
futech-391	191	23	exhibited	exhibit	VERB
futech-391	191	24	gradual	gradual	ADJ
futech-391	191	25	upregulation	upregulation	NOUN
futech-391	191	26	from	from	ADP
futech-391	191	27	early	early	ADV
futech-391	191	28	to	to	ADP
futech-391	191	29	advanced	advanced	ADJ
futech-391	191	30	diabetic	diabetic	ADJ
futech-391	191	31	nephropathy	nephropathy	NOUN
futech-391	191	32	stages	stage	NOUN
futech-391	191	33	.	.	PUNCT
futech-391	192	1	this	this	DET
futech-391	192	2	progressive	progressive	ADJ
futech-391	192	3	expression	expression	NOUN
futech-391	192	4	pattern	pattern	NOUN
futech-391	192	5	suggests	suggest	VERB
futech-391	192	6	that	that	SCONJ
futech-391	192	7	tubular	tubular	ADJ
futech-391	192	8	epithelial	epithelial	ADJ
futech-391	192	9	cell	cell	NOUN
futech-391	192	10	dysfunction	dysfunction	NOUN
futech-391	192	11	occurs	occur	VERB
futech-391	192	12	as	as	ADP
futech-391	192	13	a	a	DET
futech-391	192	14	continuous	continuous	ADJ
futech-391	192	15	process	process	NOUN
futech-391	192	16	rather	rather	ADV
futech-391	192	17	than	than	ADP
futech-391	192	18	discrete	discrete	ADJ
futech-391	192	19	pathological	pathological	ADJ
futech-391	192	20	events	event	NOUN
futech-391	192	21	.	.	PUNCT
futech-391	193	1	the	the	DET
futech-391	193	2	molecular	molecular	ADJ
futech-391	193	3	signatures	signature	NOUN
futech-391	193	4	demonstrated	demonstrate	VERB
futech-391	193	5	consistent	consistent	ADJ
futech-391	193	6	upward	upward	ADJ
futech-391	193	7	trends	trend	NOUN
futech-391	193	8	across	across	ADP
futech-391	193	9	disease	disease	NOUN
futech-391	193	10	progression	progression	NOUN
futech-391	193	11	,	,	PUNCT
futech-391	193	12	with	with	ADP
futech-391	193	13	fold	fold	ADJ
futech-391	193	14	-	-	PUNCT
futech-391	193	15	change	change	NOUN
futech-391	193	16	increases	increase	NOUN
futech-391	193	17	ranging	range	VERB
futech-391	193	18	from	from	ADP
futech-391	193	19	1.5	1.5	NUM
futech-391	193	20	-	-	NOUN
futech-391	193	21	fold	fold	ADJ
futech-391	193	22	in	in	ADV
futech-391	193	23	early	early	ADJ
futech-391	193	24	stages	stage	NOUN
futech-391	193	25	to	to	ADP
futech-391	193	26	3.2	3.2	NUM
futech-391	193	27	-	-	NOUN
futech-391	193	28	fold	fold	VERB
futech-391	193	29	in	in	ADP
futech-391	193	30	advanced	advanced	ADJ
futech-391	193	31	disease	disease	NOUN
futech-391	193	32	states	state	NOUN
futech-391	193	33	.	.	PUNCT
futech-391	194	1	these	these	DET
futech-391	194	2	findings	finding	NOUN
futech-391	194	3	support	support	VERB
futech-391	194	4	the	the	DET
futech-391	194	5	hypothesis	hypothesis	NOUN
futech-391	194	6	that	that	PRON
futech-391	194	7	tubular	tubular	ADJ
futech-391	194	8	injury	injury	NOUN
futech-391	194	9	represents	represent	VERB
futech-391	194	10	a	a	DET
futech-391	194	11	fundamental	fundamental	ADJ
futech-391	194	12	pathophysiological	pathophysiological	ADJ
futech-391	194	13	mechanism	mechanism	NOUN
futech-391	194	14	underlying	underlie	VERB
futech-391	194	15	diabetic	diabetic	ADJ
futech-391	194	16	nephropathy	nephropathy	ADJ
futech-391	194	17	progression	progression	NOUN
futech-391	194	18	,	,	PUNCT
futech-391	194	19	occurring	occur	VERB
futech-391	194	20	independently	independently	ADV
futech-391	194	21	of	of	ADP
futech-391	194	22	glomerular	glomerular	ADJ
futech-391	194	23	damage	damage	NOUN
futech-391	194	24	patterns	pattern	NOUN
futech-391	194	25	.	.	PUNCT
futech-391	195	1	the	the	DET
futech-391	195	2	comparative	comparative	ADJ
futech-391	195	3	diagnostic	diagnostic	ADJ
futech-391	195	4	performance	performance	NOUN
futech-391	195	5	analysis	analysis	NOUN
futech-391	195	6	revealed	reveal	VERB
futech-391	195	7	superior	superior	ADJ
futech-391	195	8	discriminative	discriminative	NOUN
futech-391	195	9	capability	capability	NOUN
futech-391	195	10	of	of	ADP
futech-391	195	11	novel	novel	ADJ
futech-391	195	12	tubular	tubular	ADJ
futech-391	195	13	biomarkers	biomarker	NOUN
futech-391	195	14	compared	compare	VERB
futech-391	195	15	to	to	ADP
futech-391	195	16	established	establish	VERB
futech-391	195	17	diagnostic	diagnostic	ADJ
futech-391	195	18	standards	standard	NOUN
futech-391	195	19	,	,	PUNCT
futech-391	195	20	as	as	SCONJ
futech-391	195	21	shown	show	VERB
futech-391	195	22	in	in	ADP
futech-391	195	23	figure	figure	NOUN
futech-391	195	24	5(b	5(b	NUM
futech-391	195	25	)	)	PUNCT
futech-391	195	26	.	.	PUNCT
futech-391	196	1	the	the	DET
futech-391	196	2	roc	roc	PROPN
futech-391	196	3	curve	curve	NOUN
futech-391	196	4	analysis	analysis	NOUN
futech-391	196	5	demonstrated	demonstrate	VERB
futech-391	196	6	that	that	SCONJ
futech-391	196	7	the	the	DET
futech-391	196	8	identified	identify	VERB
futech-391	196	9	tubular	tubular	ADJ
futech-391	196	10	epithelial	epithelial	ADJ
futech-391	196	11	cell	cell	NOUN
futech-391	196	12	-	-	PUNCT
futech-391	196	13	specific	specific	ADJ
futech-391	196	14	markers	marker	NOUN
futech-391	196	15	achieved	achieve	VERB
futech-391	196	16	significantly	significantly	ADV
futech-391	196	17	higher	high	ADJ
futech-391	196	18	area	area	NOUN
futech-391	196	19	under	under	ADP
futech-391	196	20	the	the	DET
futech-391	196	21	curve	curve	NOUN
futech-391	196	22	values	value	NOUN
futech-391	196	23	,	,	PUNCT
futech-391	196	24	with	with	ADP
futech-391	196	25	the	the	DET
futech-391	196	26	combined	combine	VERB
futech-391	196	27	biomarker	biomarker	NOUN
futech-391	196	28	panel	panel	NOUN
futech-391	196	29	reaching	reach	VERB
futech-391	196	30	an	an	DET
futech-391	196	31	auc	auc	NOUN
futech-391	196	32	of	of	ADP
futech-391	196	33	0.923	0.923	NUM
futech-391	196	34	compared	compare	VERB
futech-391	196	35	to	to	ADP
futech-391	196	36	current	current	ADJ
futech-391	196	37	clinical	clinical	ADJ
futech-391	196	38	gold	gold	NOUN
futech-391	196	39	standards	standard	NOUN
futech-391	196	40	,	,	PUNCT
futech-391	196	41	including	include	VERB
futech-391	196	42	serum	serum	NOUN
futech-391	196	43	creatinine	creatinine	NOUN
futech-391	196	44	(	(	PUNCT
futech-391	196	45	auc=0.687	auc=0.687	NOUN
futech-391	196	46	)	)	PUNCT
futech-391	196	47	and	and	CCONJ
futech-391	196	48	albumin	albumin	NOUN
futech-391	196	49	-	-	PUNCT
futech-391	196	50	to	to	ADP
futech-391	196	51	-	-	PUNCT
futech-391	196	52	creatinine	creatinine	NOUN
futech-391	196	53	ratio	ratio	NOUN
futech-391	196	54	(	(	PUNCT
futech-391	196	55	auc=0.742	auc=0.742	PROPN
futech-391	196	56	)	)	PUNCT
futech-391	196	57	,	,	PUNCT
futech-391	196	58	representing	represent	VERB
futech-391	196	59	a	a	DET
futech-391	196	60	35	35	NUM
futech-391	196	61	%	%	NOUN
futech-391	196	62	improvement	improvement	NOUN
futech-391	196	63	in	in	ADP
futech-391	196	64	diagnostic	diagnostic	ADJ
futech-391	196	65	accuracy	accuracy	NOUN
futech-391	196	66	.	.	PUNCT
futech-391	197	1	this	this	DET
futech-391	197	2	substantial	substantial	ADJ
futech-391	197	3	improvement	improvement	NOUN
futech-391	197	4	in	in	ADP
futech-391	197	5	diagnostic	diagnostic	ADJ
futech-391	197	6	accuracy	accuracy	NOUN
futech-391	197	7	underscores	underscore	VERB
futech-391	197	8	the	the	DET
futech-391	197	9	clinical	clinical	ADJ
futech-391	197	10	relevance	relevance	NOUN
futech-391	197	11	of	of	ADP
futech-391	197	12	tubularspecific	tubularspecific	ADJ
futech-391	197	13	molecular	molecular	ADJ
futech-391	197	14	signatures	signature	NOUN
futech-391	197	15	in	in	ADP
futech-391	197	16	diabetic	diabetic	ADJ
futech-391	197	17	nephropathy	nephropathy	ADJ
futech-391	197	18	detection	detection	NOUN
futech-391	197	19	.	.	PUNCT
futech-391	198	1	the	the	DET
futech-391	198	2	enhanced	enhanced	ADJ
futech-391	198	3	sensitivity	sensitivity	NOUN
futech-391	198	4	and	and	CCONJ
futech-391	198	5	specificity	specificity	NOUN
futech-391	198	6	profiles	profile	NOUN
futech-391	198	7	indicate	indicate	VERB
futech-391	198	8	that	that	SCONJ
futech-391	198	9	these	these	DET
futech-391	198	10	biomarkers	biomarker	NOUN
futech-391	198	11	could	could	AUX
futech-391	198	12	facilitate	facilitate	VERB
futech-391	198	13	earlier	early	ADJ
futech-391	198	14	disease	disease	NOUN
futech-391	198	15	identification	identification	NOUN
futech-391	198	16	and	and	CCONJ
futech-391	198	17	more	more	ADV
futech-391	198	18	precise	precise	ADJ
futech-391	198	19	risk	risk	NOUN
futech-391	198	20	stratification	stratification	NOUN
futech-391	198	21	in	in	ADP
futech-391	198	22	clinical	clinical	ADJ
futech-391	198	23	practice	practice	NOUN
futech-391	198	24	.	.	PUNCT
futech-391	199	1	the	the	DET
futech-391	199	2	independent	independent	ADJ
futech-391	199	3	cohort	cohort	NOUN
futech-391	199	4	validation	validation	NOUN
futech-391	199	5	confirmed	confirm	VERB
futech-391	199	6	the	the	DET
futech-391	199	7	robustness	robustness	NOUN
futech-391	199	8	and	and	CCONJ
futech-391	199	9	generalizability	generalizability	NOUN
futech-391	199	10	of	of	ADP
futech-391	199	11	identified	identify	VERB
futech-391	199	12	biomarkers	biomarker	NOUN
futech-391	199	13	across	across	ADP
futech-391	199	14	diverse	diverse	ADJ
futech-391	199	15	patient	patient	ADJ
futech-391	199	16	populations	population	NOUN
futech-391	199	17	,	,	PUNCT
futech-391	199	18	as	as	SCONJ
futech-391	199	19	demonstrated	demonstrate	VERB
futech-391	199	20	in	in	ADP
futech-391	199	21	figure	figure	NOUN
futech-391	199	22	5(c	5(c	NUM
futech-391	199	23	)	)	PUNCT
futech-391	199	24	.	.	PUNCT
futech-391	200	1	the	the	DET
futech-391	200	2	study	study	NOUN
futech-391	200	3	successfully	successfully	ADV
futech-391	200	4	validated	validate	VERB
futech-391	200	5	biomarker	biomarker	NOUN
futech-391	200	6	performance	performance	NOUN
futech-391	200	7	in	in	ADP
futech-391	200	8	three	three	NUM
futech-391	200	9	geographically	geographically	ADV
futech-391	200	10	distinct	distinct	ADJ
futech-391	200	11	cohorts	cohort	NOUN
futech-391	200	12	:	:	PUNCT
futech-391	200	13	european	european	ADJ
futech-391	200	14	cohort	cohort	NOUN
futech-391	200	15	(	(	PUNCT
futech-391	200	16	n=89	n=89	ADV
futech-391	200	17	,	,	PUNCT
futech-391	200	18	age	age	NOUN
futech-391	200	19	64.2±8.5	64.2±8.5	NUM
futech-391	200	20	years	year	NOUN
futech-391	200	21	,	,	PUNCT
futech-391	200	22	58	58	NUM
futech-391	200	23	%	%	NOUN
futech-391	200	24	male	male	NOUN
futech-391	200	25	,	,	PUNCT
futech-391	200	26	65	65	NUM
futech-391	200	27	%	%	NOUN
futech-391	200	28	early	early	ADJ
futech-391	200	29	-	-	PUNCT
futech-391	200	30	stage	stage	NOUN
futech-391	200	31	)	)	PUNCT
futech-391	200	32	,	,	PUNCT
futech-391	200	33	asian	asian	ADJ
futech-391	200	34	cohort	cohort	NOUN
futech-391	200	35	(	(	PUNCT
futech-391	200	36	n=76	n=76	NOUN
futech-391	200	37	,	,	PUNCT
futech-391	200	38	age	age	NOUN
futech-391	200	39	61.8±7.2	61.8±7.2	NUM
futech-391	200	40	years	year	NOUN
futech-391	200	41	,	,	PUNCT
futech-391	200	42	52	52	NUM
futech-391	200	43	%	%	NOUN
futech-391	200	44	male	male	NOUN
futech-391	200	45	,	,	PUNCT
futech-391	200	46	71	71	NUM
futech-391	200	47	%	%	NOUN
futech-391	200	48	early	early	ADJ
futech-391	200	49	-	-	PUNCT
futech-391	200	50	stage	stage	NOUN
futech-391	200	51	)	)	PUNCT
futech-391	200	52	,	,	PUNCT
futech-391	200	53	and	and	CCONJ
futech-391	200	54	north	north	ADJ
futech-391	200	55	american	american	ADJ
futech-391	200	56	cohort	cohort	NOUN
futech-391	200	57	(	(	PUNCT
futech-391	200	58	n=82	n=82	NOUN
futech-391	200	59	,	,	PUNCT
futech-391	200	60	age	age	NOUN
futech-391	200	61	66.1	66.1	NUM
futech-391	200	62	±	±	NUM
futech-391	200	63	9.1	9.1	NUM
futech-391	200	64	years	year	NOUN
futech-391	200	65	,	,	PUNCT
futech-391	200	66	61	61	NUM
futech-391	200	67	%	%	NOUN
futech-391	200	68	male	male	NOUN
futech-391	200	69	,	,	PUNCT
futech-391	200	70	59	59	NUM
futech-391	200	71	%	%	NOUN
futech-391	200	72	early	early	ADJ
futech-391	200	73	-	-	PUNCT
futech-391	200	74	stage	stage	NOUN
futech-391	200	75	)	)	PUNCT
futech-391	200	76	,	,	PUNCT
futech-391	200	77	maintaining	maintain	VERB
futech-391	200	78	consistent	consistent	ADJ
futech-391	200	79	diagnostic	diagnostic	ADJ
futech-391	200	80	accuracy	accuracy	NOUN
futech-391	200	81	with	with	ADP
futech-391	200	82	minimal	minimal	ADJ
futech-391	200	83	variation	variation	NOUN
futech-391	200	84	in	in	ADP
futech-391	200	85	auc	auc	ADJ
futech-391	200	86	values	value	NOUN
futech-391	200	87	across	across	ADP
futech-391	200	88	different	different	ADJ
futech-391	200	89	populations	population	NOUN
futech-391	200	90	(	(	PUNCT
futech-391	200	91	0.9410.953	0.9410.953	NUM
futech-391	200	92	)	)	PUNCT
futech-391	200	93	.	.	PUNCT
futech-391	201	1	this	this	DET
futech-391	201	2	validation	validation	NOUN
futech-391	201	3	approach	approach	NOUN
futech-391	201	4	addressed	address	VERB
futech-391	201	5	potential	potential	ADJ
futech-391	201	6	concerns	concern	NOUN
futech-391	201	7	regarding	regard	VERB
futech-391	201	8	population	population	NOUN
futech-391	201	9	-	-	PUNCT
futech-391	201	10	specific	specific	ADJ
futech-391	201	11	genetic	genetic	ADJ
futech-391	201	12	variations	variation	NOUN
futech-391	201	13	and	and	CCONJ
futech-391	201	14	environmental	environmental	ADJ
futech-391	201	15	factors	factor	NOUN
futech-391	201	16	that	that	PRON
futech-391	201	17	might	might	AUX
futech-391	201	18	influence	influence	VERB
futech-391	201	19	biomarker	biomarker	NOUN
futech-391	201	20	expression	expression	NOUN
futech-391	201	21	patterns	pattern	NOUN
futech-391	201	22	.	.	PUNCT
futech-391	202	1	the	the	DET
futech-391	202	2	consistent	consistent	ADJ
futech-391	202	3	performance	performance	NOUN
futech-391	202	4	across	across	ADP
futech-391	202	5	multiple	multiple	ADJ
futech-391	202	6	validation	validation	NOUN
futech-391	202	7	cohorts	cohort	NOUN
futech-391	202	8	strengthens	strengthen	VERB
futech-391	202	9	the	the	DET
futech-391	202	10	evidence	evidence	NOUN
futech-391	202	11	for	for	ADP
futech-391	202	12	clinical	clinical	ADJ
futech-391	202	13	translation	translation	NOUN
futech-391	202	14	and	and	CCONJ
futech-391	202	15	supports	support	VERB
futech-391	202	16	the	the	DET
futech-391	202	17	potential	potential	NOUN
futech-391	202	18	for	for	ADP
futech-391	202	19	widespread	widespread	ADJ
futech-391	202	20	implementation	implementation	NOUN
futech-391	202	21	in	in	ADP
futech-391	202	22	routine	routine	ADJ
futech-391	202	23	diabetic	diabetic	ADJ
futech-391	202	24	nephropathy	nephropathy	NOUN
futech-391	202	25	screening	screen	VERB
futech-391	202	26	protocols	protocol	NOUN
futech-391	202	27	.	.	PUNCT
futech-391	203	1	table	table	NOUN
futech-391	203	2	3	3	NUM
futech-391	203	3	.	.	X
futech-391	203	4	tubular	tubular	ADJ
futech-391	203	5	epithelial	epithelial	ADJ
futech-391	203	6	cell	cell	NOUN
futech-391	203	7	-	-	PUNCT
futech-391	203	8	specific	specific	ADJ
futech-391	203	9	candidate	candidate	NOUN
futech-391	203	10	biomarkers	biomarker	NOUN
futech-391	203	11	in	in	ADP
futech-391	203	12	diabetic	diabetic	ADJ
futech-391	203	13	nephropathy	nephropathy	NOUN
futech-391	203	14	biomarker	biomarker	ADP
futech-391	203	15	molecular	molecular	ADJ
futech-391	203	16	type	type	NOUN
futech-391	203	17	importance	importance	NOUN
futech-391	203	18	score	score	NOUN
futech-391	203	19	fold	fold	NOUN
futech-391	203	20	change	change	NOUN
futech-391	203	21	p	p	NOUN
futech-391	203	22	-	-	PUNCT
futech-391	203	23	value	value	NOUN
futech-391	203	24	auc	auc	ADJ
futech-391	203	25	functional	functional	ADJ
futech-391	203	26	category	category	NOUN
futech-391	203	27	kim-1	kim-1	PART
futech-391	203	28	protein	protein	NOUN
futech-391	203	29	0.092	0.092	NUM
futech-391	203	30	3.2↑	3.2↑	NUM
futech-391	203	31	<	<	NOUN
futech-391	203	32	0.001	0.001	NUM
futech-391	203	33	0.886	0.886	NUM
futech-391	203	34	acute	acute	ADJ
futech-391	203	35	injury	injury	NOUN
futech-391	203	36	marker	marker	NOUN
futech-391	203	37	ngal	ngal	ADJ
futech-391	203	38	protein	protein	NOUN
futech-391	203	39	0.087	0.087	NUM
futech-391	203	40	2.8↑	2.8↑	NUM
futech-391	203	41	<	<	X
futech-391	203	42	0.001	0.001	NUM
futech-391	203	43	0.872	0.872	NUM
futech-391	203	44	inflammatory	inflammatory	ADJ
futech-391	203	45	stress	stress	NOUN
futech-391	203	46	response	response	NOUN
futech-391	203	47	l	l	NOUN
futech-391	203	48	-	-	ADJ
futech-391	203	49	fabp	fabp	VERB
futech-391	203	50	protein	protein	NOUN
futech-391	203	51	0.084	0.084	NUM
futech-391	203	52	2.5↑	2.5↑	NUM
futech-391	203	53	<	<	NOUN
futech-391	203	54	0.001	0.001	NUM
futech-391	203	55	0.863	0.863	NUM
futech-391	203	56	lipid	lipid	NOUN
futech-391	203	57	metabolism	metabolism	NOUN
futech-391	203	58	injury	injury	NOUN
futech-391	203	59	cystatin	cystatin	PROPN
futech-391	203	60	c	c	PROPN
futech-391	203	61	protein	protein	NOUN
futech-391	203	62	0.076	0.076	NUM
futech-391	203	63	2.1↑	2.1↑	NUM
futech-391	203	64	<	<	X
futech-391	203	65	0.001	0.001	NUM
futech-391	203	66	0.845	0.845	NUM
futech-391	203	67	renal	renal	ADJ
futech-391	203	68	function	function	NOUN
futech-391	203	69	assessment	assessment	NOUN
futech-391	203	70	β	β	ADP
futech-391	203	71	2	2	NUM
futech-391	203	72	-	-	PUNCT
futech-391	203	73	mg	mg	NOUN
futech-391	203	74	protein	protein	NOUN
futech-391	203	75	0.072	0.072	NUM
futech-391	203	76	1.9↑	1.9↑	NUM
futech-391	203	77	0.002	0.002	NUM
futech-391	203	78	0.831	0.831	NUM
futech-391	203	79	proximal	proximal	ADJ
futech-391	203	80	tubule	tubule	NOUN
futech-391	203	81	function	function	NOUN
futech-391	203	82	podocalyxin	podocalyxin	NOUN
futech-391	203	83	protein	protein	NOUN
futech-391	203	84	0.068	0.068	NUM
futech-391	203	85	1.7↑	1.7↑	NUM
futech-391	203	86	0.003	0.003	NUM
futech-391	203	87	0.819	0.819	NUM
futech-391	203	88	epithelial	epithelial	ADJ
futech-391	203	89	cell	cell	NOUN
futech-391	203	90	damage	damage	NOUN
futech-391	203	91	nephrin	nephrin	NOUN
futech-391	203	92	protein	protein	NOUN
futech-391	203	93	0.065	0.065	NUM
futech-391	203	94	1.5↓	1.5↓	NUM
futech-391	203	95	0.004	0.004	NUM
futech-391	203	96	0.807	0.807	NUM
futech-391	203	97	barrier	barrier	NOUN
futech-391	203	98	dysfunction	dysfunction	NOUN
futech-391	203	99	timp-2	timp-2	NUM
futech-391	203	100	protein	protein	NOUN
futech-391	203	101	0.061	0.061	NUM
futech-391	203	102	1.8↑	1.8↑	NUM
futech-391	203	103	0.005	0.005	NUM
futech-391	203	104	0.794	0.794	NUM
futech-391	203	105	fibrosis	fibrosis	NOUN
futech-391	203	106	progression	progression	NOUN
futech-391	203	107	clusterin	clusterin	NOUN
futech-391	203	108	protein	protein	NOUN
futech-391	203	109	0.058	0.058	NUM
futech-391	203	110	1.6↑	1.6↑	NUM
futech-391	203	111	0.008	0.008	NUM
futech-391	203	112	0.782	0.782	NUM
futech-391	203	113	apoptosis	apoptosis	NOUN
futech-391	203	114	regulation	regulation	NOUN
futech-391	203	115	mcp-1	mcp-1	NOUN
futech-391	203	116	cytokine	cytokine	NOUN
futech-391	203	117	0.054	0.054	NUM
futech-391	203	118	2.3↑	2.3↑	NUM
futech-391	203	119	0.011	0.011	NUM
futech-391	203	120	0.768	0.768	NUM
futech-391	203	121	inflammatory	inflammatory	ADJ
futech-391	203	122	recruitment	recruitment	NOUN
futech-391	203	123	note	note	NOUN
futech-391	203	124	:	:	PUNCT
futech-391	204	1	importance	importance	NOUN
futech-391	204	2	scores	score	NOUN
futech-391	204	3	derived	derive	VERB
futech-391	204	4	from	from	ADP
futech-391	204	5	ensemble	ensemble	ADJ
futech-391	204	6	model	model	NOUN
futech-391	204	7	feature	feature	NOUN
futech-391	204	8	weights	weight	NOUN
futech-391	204	9	;	;	PUNCT
futech-391	204	10	fold	fold	NOUN
futech-391	204	11	change	change	NOUN
futech-391	204	12	represents	represent	VERB
futech-391	204	13	dn	dn	PROPN
futech-391	204	14	group	group	PROPN
futech-391	204	15	relative	relative	ADJ
futech-391	204	16	to	to	ADP
futech-391	204	17	control	control	NOUN
futech-391	204	18	(	(	PUNCT
futech-391	204	19	↑upregulated	↑upregulate	VERB
futech-391	204	20	,	,	PUNCT
futech-391	204	21	↓downregulated	↓downregulate	VERB
futech-391	204	22	)	)	PUNCT
futech-391	204	23	;	;	PUNCT
futech-391	204	24	p	p	X
futech-391	204	25	-	-	PUNCT
futech-391	204	26	values	value	NOUN
futech-391	204	27	adjusted	adjust	VERB
futech-391	204	28	by	by	ADP
futech-391	204	29	fdr	fdr	PROPN
futech-391	204	30	correction	correction	NOUN
futech-391	204	31	;	;	PUNCT
futech-391	204	32	auc	auc	NOUN
futech-391	204	33	indicates	indicate	VERB
futech-391	204	34	single	single	ADJ
futech-391	204	35	biomarker	biomarker	NOUN
futech-391	204	36	diagnostic	diagnostic	ADJ
futech-391	204	37	performance	performance	NOUN
futech-391	204	38	;	;	PUNCT
futech-391	204	39	β2	β2	NOUN
futech-391	204	40	-	-	PUNCT
futech-391	204	41	mg	mg	PROPN
futech-391	204	42	:	:	PUNCT
futech-391	204	43	β2	β2	PROPN
futech-391	204	44	-	-	PUNCT
futech-391	204	45	microglobulin	microglobulin	PROPN
futech-391	204	46	;	;	PUNCT
futech-391	204	47	timp-2	timp-2	NUM
futech-391	204	48	:	:	PUNCT
futech-391	204	49	tissue	tissue	NOUN
futech-391	204	50	inhibitor	inhibitor	NOUN
futech-391	204	51	of	of	ADP
futech-391	204	52	metalloproteinase-2	metalloproteinase-2	PROPN
futech-391	204	53	;	;	PUNCT
futech-391	204	54	mcp-1	mcp-1	NOUN
futech-391	204	55	:	:	PUNCT
futech-391	204	56	monocyte	monocyte	NOUN
futech-391	204	57	chemoattractant	chemoattractant	PROPN
futech-391	204	58	protein-1	protein-1	PROPN
futech-391	204	59	.	.	PUNCT
futech-391	205	1	all	all	DET
futech-391	205	2	candidate	candidate	NOUN
futech-391	205	3	biomarkers	biomarker	NOUN
futech-391	205	4	validated	validate	VERB
futech-391	205	5	in	in	ADP
futech-391	205	6	independent	independent	ADJ
futech-391	205	7	cohorts	cohort	NOUN
futech-391	205	8	.	.	PUNCT
futech-391	206	1	w.	w.	PROPN
futech-391	206	2	li	li	PROPN
futech-391	206	3	&	&	CCONJ
futech-391	206	4	sp	sp	PROPN
futech-391	206	5	.	.	PROPN
futech-391	206	6	chandran	chandran	PROPN
futech-391	206	7	/future	/future	PUNCT
futech-391	206	8	technology	technology	PROPN
futech-391	206	9	august	august	PROPN
futech-391	206	10	2025|	2025|	NUM
futech-391	206	11	volume	volume	NOUN
futech-391	206	12	04	04	NUM
futech-391	207	1	|	|	NOUN
futech-391	207	2	issue	issue	NOUN
futech-391	207	3	03	03	NUM
futech-391	208	1	|	|	ADV
futech-391	208	2	pages	page	NOUN
futech-391	208	3	193	193	NUM
futech-391	208	4	-	-	SYM
futech-391	208	5	203	203	NUM
futech-391	208	6	200	200	NUM
futech-391	208	7	the	the	DET
futech-391	208	8	functional	functional	ADJ
futech-391	208	9	enrichment	enrichment	NOUN
futech-391	208	10	analysis	analysis	NOUN
futech-391	208	11	elucidated	elucidate	VERB
futech-391	208	12	the	the	DET
futech-391	208	13	biological	biological	ADJ
futech-391	208	14	mechanisms	mechanism	NOUN
futech-391	208	15	underlying	underlie	VERB
futech-391	208	16	tubular	tubular	ADJ
futech-391	208	17	epithelial	epithelial	ADJ
futech-391	208	18	cell	cell	NOUN
futech-391	208	19	dysfunction	dysfunction	NOUN
futech-391	208	20	in	in	ADP
futech-391	208	21	diabetic	diabetic	ADJ
futech-391	208	22	nephropathy	nephropathy	NOUN
futech-391	208	23	,	,	PUNCT
futech-391	208	24	as	as	SCONJ
futech-391	208	25	illustrated	illustrate	VERB
futech-391	208	26	in	in	ADP
futech-391	208	27	figure	figure	NOUN
futech-391	208	28	5(d	5(d	NUM
futech-391	208	29	)	)	PUNCT
futech-391	208	30	.	.	PUNCT
futech-391	209	1	network	network	NOUN
futech-391	209	2	analysis	analysis	NOUN
futech-391	209	3	revealed	reveal	VERB
futech-391	209	4	interconnected	interconnected	ADJ
futech-391	209	5	pathways	pathway	NOUN
futech-391	209	6	involving	involve	VERB
futech-391	209	7	the	the	DET
futech-391	209	8	identified	identify	VERB
futech-391	209	9	biomarkers	biomarker	NOUN
futech-391	209	10	,	,	PUNCT
futech-391	209	11	with	with	ADP
futech-391	209	12	pathway	pathway	NOUN
futech-391	209	13	analysis	analysis	NOUN
futech-391	209	14	showing	show	VERB
futech-391	209	15	significant	significant	ADJ
futech-391	209	16	enrichment	enrichment	NOUN
futech-391	209	17	in	in	ADP
futech-391	209	18	inflammatory	inflammatory	ADJ
futech-391	209	19	response	response	NOUN
futech-391	209	20	pathways	pathway	NOUN
futech-391	209	21	,	,	PUNCT
futech-391	209	22	oxidative	oxidative	ADJ
futech-391	209	23	stress	stress	NOUN
futech-391	209	24	mechanisms	mechanism	NOUN
futech-391	209	25	,	,	PUNCT
futech-391	209	26	and	and	CCONJ
futech-391	209	27	epithelial	epithelial	ADJ
futech-391	209	28	-	-	PUNCT
futech-391	209	29	tomesenchymal	tomesenchymal	ADJ
futech-391	209	30	transition	transition	NOUN
futech-391	209	31	processes	process	NOUN
futech-391	209	32	,	,	PUNCT
futech-391	209	33	with	with	ADP
futech-391	209	34	p	p	NOUN
futech-391	209	35	-	-	PUNCT
futech-391	209	36	values	value	NOUN
futech-391	209	37	below	below	ADP
futech-391	209	38	0.01	0.01	NUM
futech-391	209	39	for	for	ADP
futech-391	209	40	all	all	DET
futech-391	209	41	major	major	ADJ
futech-391	209	42	functional	functional	ADJ
futech-391	209	43	categories	category	NOUN
futech-391	209	44	.	.	PUNCT
futech-391	210	1	these	these	DET
futech-391	210	2	mechanistic	mechanistic	ADJ
futech-391	210	3	insights	insight	NOUN
futech-391	210	4	provide	provide	VERB
futech-391	210	5	valuable	valuable	ADJ
futech-391	210	6	understanding	understanding	NOUN
futech-391	210	7	of	of	ADP
futech-391	210	8	the	the	DET
futech-391	210	9	molecular	molecular	ADJ
futech-391	210	10	processes	process	NOUN
futech-391	210	11	driving	drive	VERB
futech-391	210	12	tubular	tubular	ADJ
futech-391	210	13	damage	damage	NOUN
futech-391	210	14	and	and	CCONJ
futech-391	210	15	suggest	suggest	VERB
futech-391	210	16	potential	potential	ADJ
futech-391	210	17	therapeutic	therapeutic	ADJ
futech-391	210	18	targets	target	NOUN
futech-391	210	19	for	for	ADP
futech-391	210	20	intervention	intervention	NOUN
futech-391	210	21	strategies	strategy	NOUN
futech-391	210	22	.	.	PUNCT
futech-391	211	1	the	the	DET
futech-391	211	2	enriched	enrich	VERB
futech-391	211	3	pathways	pathway	NOUN
futech-391	211	4	encompass	encompass	VERB
futech-391	211	5	diverse	diverse	ADJ
futech-391	211	6	cellular	cellular	ADJ
futech-391	211	7	functions	function	NOUN
futech-391	211	8	,	,	PUNCT
futech-391	211	9	including	include	VERB
futech-391	211	10	apoptosis	apoptosis	NOUN
futech-391	211	11	regulation	regulation	NOUN
futech-391	211	12	,	,	PUNCT
futech-391	211	13	metabolic	metabolic	NOUN
futech-391	211	14	dysfunction	dysfunction	NOUN
futech-391	211	15	,	,	PUNCT
futech-391	211	16	and	and	CCONJ
futech-391	211	17	fibrosis	fibrosis	NOUN
futech-391	211	18	progression	progression	NOUN
futech-391	211	19	,	,	PUNCT
futech-391	211	20	reflecting	reflect	VERB
futech-391	211	21	the	the	DET
futech-391	211	22	complex	complex	ADJ
futech-391	211	23	pathophysiological	pathophysiological	ADJ
futech-391	211	24	landscape	landscape	NOUN
futech-391	211	25	of	of	ADP
futech-391	211	26	diabetic	diabetic	ADJ
futech-391	211	27	kidney	kidney	NOUN
futech-391	211	28	disease	disease	NOUN
futech-391	211	29	at	at	ADP
futech-391	211	30	the	the	DET
futech-391	211	31	tubular	tubular	ADJ
futech-391	211	32	epithelial	epithelial	ADJ
futech-391	211	33	cell	cell	NOUN
futech-391	211	34	level	level	NOUN
futech-391	211	35	.	.	PUNCT
futech-391	212	1	4	4	X
futech-391	212	2	.	.	X
futech-391	212	3	discussion	discussion	NOUN
futech-391	212	4	the	the	DET
futech-391	212	5	discovery	discovery	NOUN
futech-391	212	6	of	of	ADP
futech-391	212	7	tubular	tubular	ADJ
futech-391	212	8	epithelial	epithelial	ADJ
futech-391	212	9	cell	cell	NOUN
futech-391	212	10	-	-	PUNCT
futech-391	212	11	specific	specific	ADJ
futech-391	212	12	biomarkers	biomarker	NOUN
futech-391	212	13	using	use	VERB
futech-391	212	14	machine	machine	NOUN
futech-391	212	15	learning	learning	NOUN
futech-391	212	16	-	-	PUNCT
futech-391	212	17	based	base	VERB
futech-391	212	18	multi	multi	ADJ
futech-391	212	19	-	-	ADJ
futech-391	212	20	omics	omics	ADJ
futech-391	212	21	integration	integration	NOUN
futech-391	212	22	strongly	strongly	ADV
futech-391	212	23	supports	support	VERB
futech-391	212	24	the	the	DET
futech-391	212	25	pathophysiological	pathophysiological	ADJ
futech-391	212	26	relevance	relevance	NOUN
futech-391	212	27	of	of	ADP
futech-391	212	28	tubulointerstitial	tubulointerstitial	ADJ
futech-391	212	29	damage	damage	NOUN
futech-391	212	30	in	in	ADP
futech-391	212	31	the	the	DET
futech-391	212	32	progression	progression	NOUN
futech-391	212	33	of	of	ADP
futech-391	212	34	diabetic	diabetic	ADJ
futech-391	212	35	nephropathy	nephropathy	NOUN
futech-391	212	36	.	.	PUNCT
futech-391	213	1	the	the	DET
futech-391	213	2	study	study	NOUN
futech-391	213	3	shows	show	VERB
futech-391	213	4	that	that	SCONJ
futech-391	213	5	kim-1	kim-1	VERB
futech-391	213	6	,	,	PUNCT
futech-391	213	7	ngal	ngal	ADJ
futech-391	213	8	,	,	PUNCT
futech-391	213	9	and	and	CCONJ
futech-391	213	10	l	l	NOUN
futech-391	213	11	-	-	NOUN
futech-391	213	12	fabp	fabp	PROPN
futech-391	213	13	are	be	AUX
futech-391	213	14	critical	critical	ADJ
futech-391	213	15	molecular	molecular	ADJ
futech-391	213	16	markers	marker	NOUN
futech-391	213	17	of	of	ADP
futech-391	213	18	tubular	tubular	ADJ
futech-391	213	19	epithelial	epithelial	ADJ
futech-391	213	20	cell	cell	NOUN
futech-391	213	21	impairment	impairment	NOUN
futech-391	213	22	and	and	CCONJ
futech-391	213	23	that	that	SCONJ
futech-391	213	24	their	their	PRON
futech-391	213	25	increased	increase	VERB
futech-391	213	26	expression	expression	NOUN
futech-391	213	27	is	be	AUX
futech-391	213	28	directly	directly	ADV
futech-391	213	29	associated	associate	VERB
futech-391	213	30	with	with	ADP
futech-391	213	31	disease	disease	NOUN
futech-391	213	32	severity	severity	NOUN
futech-391	213	33	and	and	CCONJ
futech-391	213	34	clinical	clinical	ADJ
futech-391	213	35	prognosis	prognosis	NOUN
futech-391	213	36	[	[	X
futech-391	213	37	27	27	NUM
futech-391	213	38	]	]	PUNCT
futech-391	213	39	.	.	PUNCT
futech-391	214	1	these	these	DET
futech-391	214	2	biomarkers	biomarker	NOUN
futech-391	214	3	indicate	indicate	VERB
futech-391	214	4	distinct	distinct	ADJ
futech-391	214	5	pathobiological	pathobiological	ADJ
futech-391	214	6	changes	change	NOUN
futech-391	214	7	such	such	ADJ
futech-391	214	8	as	as	ADP
futech-391	214	9	cellular	cellular	ADJ
futech-391	214	10	apoptosis	apoptosis	NOUN
futech-391	214	11	,	,	PUNCT
futech-391	214	12	inflammatory	inflammatory	ADJ
futech-391	214	13	stress	stress	NOUN
futech-391	214	14	response	response	NOUN
futech-391	214	15	,	,	PUNCT
futech-391	214	16	and	and	CCONJ
futech-391	214	17	metabolic	metabolic	NOUN
futech-391	214	18	derangement	derangement	NOUN
futech-391	214	19	that	that	PRON
futech-391	214	20	define	define	VERB
futech-391	214	21	diabetic	diabetic	ADJ
futech-391	214	22	kidney	kidney	NOUN
futech-391	214	23	disease	disease	NOUN
futech-391	214	24	at	at	ADP
futech-391	214	25	the	the	DET
futech-391	214	26	level	level	NOUN
futech-391	214	27	of	of	ADP
futech-391	214	28	the	the	DET
futech-391	214	29	tubule	tubule	NOUN
futech-391	214	30	[	[	X
futech-391	214	31	28	28	NUM
futech-391	214	32	]	]	PUNCT
futech-391	214	33	.	.	PUNCT
futech-391	215	1	the	the	DET
futech-391	215	2	cumulative	cumulative	ADJ
futech-391	215	3	increase	increase	NOUN
futech-391	215	4	of	of	ADP
futech-391	215	5	these	these	DET
futech-391	215	6	markers	marker	NOUN
futech-391	215	7	at	at	ADP
futech-391	215	8	different	different	ADJ
futech-391	215	9	stages	stage	NOUN
futech-391	215	10	of	of	ADP
futech-391	215	11	the	the	DET
futech-391	215	12	disease	disease	NOUN
futech-391	215	13	supports	support	VERB
futech-391	215	14	newer	new	ADJ
futech-391	215	15	evidence	evidence	NOUN
futech-391	215	16	proposing	propose	VERB
futech-391	215	17	that	that	SCONJ
futech-391	215	18	tubular	tubular	ADJ
futech-391	215	19	injury	injury	NOUN
futech-391	215	20	might	might	AUX
futech-391	215	21	occur	occur	VERB
futech-391	215	22	early	early	ADV
futech-391	215	23	and	and	CCONJ
futech-391	215	24	lead	lead	VERB
futech-391	215	25	to	to	ADP
futech-391	215	26	glomerular	glomerular	ADJ
futech-391	215	27	damage	damage	NOUN
futech-391	215	28	,	,	PUNCT
futech-391	215	29	contrary	contrary	ADV
futech-391	215	30	to	to	ADP
futech-391	215	31	established	established	ADJ
futech-391	215	32	paradigms	paradigm	NOUN
futech-391	215	33	,	,	PUNCT
futech-391	215	34	which	which	PRON
futech-391	215	35	hold	hold	VERB
futech-391	215	36	that	that	DET
futech-391	215	37	focus	focus	NOUN
futech-391	215	38	on	on	ADP
futech-391	215	39	proteinuria	proteinuria	NOUN
futech-391	215	40	and	and	CCONJ
futech-391	215	41	glomerular	glomerular	ADJ
futech-391	215	42	filtration	filtration	NOUN
futech-391	215	43	rate	rate	NOUN
futech-391	215	44	mark	mark	VERB
futech-391	215	45	the	the	DET
futech-391	215	46	clinical	clinical	ADJ
futech-391	215	47	windows	window	NOUN
futech-391	215	48	for	for	ADP
futech-391	215	49	diagnosis	diagnosis	NOUN
futech-391	215	50	[	[	X
futech-391	215	51	29	29	NUM
futech-391	215	52	]	]	PUNCT
futech-391	215	53	.	.	PUNCT
futech-391	216	1	insights	insight	NOUN
futech-391	216	2	from	from	ADP
futech-391	216	3	pathway	pathway	NOUN
futech-391	216	4	enrichment	enrichment	NOUN
futech-391	216	5	analysis	analysis	NOUN
futech-391	216	6	regarding	regard	VERB
futech-391	216	7	the	the	DET
futech-391	216	8	main	main	ADJ
futech-391	216	9	and	and	CCONJ
futech-391	216	10	most	most	ADV
futech-391	216	11	active	active	ADJ
futech-391	216	12	pathways	pathway	NOUN
futech-391	216	13	provided	provide	VERB
futech-391	216	14	in	in	ADP
futech-391	216	15	the	the	DET
futech-391	216	16	other	other	ADJ
futech-391	216	17	parts	part	NOUN
futech-391	216	18	of	of	ADP
futech-391	216	19	the	the	DET
futech-391	216	20	results	result	NOUN
futech-391	216	21	concerning	concern	VERB
futech-391	216	22	the	the	DET
futech-391	216	23	biology	biology	NOUN
futech-391	216	24	of	of	ADP
futech-391	216	25	the	the	DET
futech-391	216	26	algorithms	algorithm	NOUN
futech-391	216	27	explaining	explain	VERB
futech-391	216	28	the	the	DET
futech-391	216	29	phenomena	phenomenon	NOUN
futech-391	216	30	of	of	ADP
futech-391	216	31	the	the	DET
futech-391	216	32	dysfunction	dysfunction	NOUN
futech-391	216	33	of	of	ADP
futech-391	216	34	tubular	tubular	ADJ
futech-391	216	35	epithelial	epithelial	ADJ
futech-391	216	36	cells	cell	NOUN
futech-391	216	37	,	,	PUNCT
futech-391	216	38	especially	especially	ADV
futech-391	216	39	with	with	ADP
futech-391	216	40	regard	regard	NOUN
futech-391	216	41	to	to	ADP
futech-391	216	42	the	the	DET
futech-391	216	43	processes	process	NOUN
futech-391	216	44	of	of	ADP
futech-391	216	45	epithelial	epithelial	NOUN
futech-391	216	46	-	-	PUNCT
futech-391	216	47	to	to	ADP
futech-391	216	48	-	-	PUNCT
futech-391	216	49	mesenchymal	mesenchymal	NOUN
futech-391	216	50	transition	transition	NOUN
futech-391	216	51	and	and	CCONJ
futech-391	216	52	oxidative	oxidative	ADJ
futech-391	216	53	stress	stress	NOUN
futech-391	216	54	that	that	PRON
futech-391	216	55	drive	drive	VERB
futech-391	216	56	the	the	DET
futech-391	216	57	decline	decline	NOUN
futech-391	216	58	in	in	ADP
futech-391	216	59	kidney	kidney	NOUN
futech-391	216	60	function	function	NOUN
futech-391	216	61	over	over	ADP
futech-391	216	62	time	time	NOUN
futech-391	216	63	,	,	PUNCT
futech-391	216	64	also	also	ADV
futech-391	216	65	aid	aid	VERB
futech-391	216	66	in	in	ADP
futech-391	216	67	understanding	understand	VERB
futech-391	216	68	the	the	DET
futech-391	216	69	problem	problem	NOUN
futech-391	216	70	.	.	PUNCT
futech-391	217	1	the	the	DET
futech-391	217	2	innovations	innovation	NOUN
futech-391	217	3	in	in	ADP
futech-391	217	4	methods	method	NOUN
futech-391	217	5	employed	employ	VERB
futech-391	217	6	by	by	ADP
futech-391	217	7	these	these	DET
futech-391	217	8	researchers	researcher	NOUN
futech-391	217	9	represent	represent	VERB
futech-391	217	10	a	a	DET
futech-391	217	11	technological	technological	ADJ
futech-391	217	12	leap	leap	NOUN
futech-391	217	13	forward	forward	ADV
futech-391	217	14	in	in	ADP
futech-391	217	15	biomarker	biomarker	NOUN
futech-391	217	16	discovery	discovery	NOUN
futech-391	217	17	for	for	ADP
futech-391	217	18	diabetic	diabetic	ADJ
futech-391	217	19	nephropathy	nephropathy	ADJ
futech-391	217	20	research	research	NOUN
futech-391	217	21	.	.	PUNCT
futech-391	218	1	the	the	DET
futech-391	218	2	integration	integration	NOUN
futech-391	218	3	of	of	ADP
futech-391	218	4	multiple	multiple	ADJ
futech-391	218	5	omics	omic	NOUN
futech-391	218	6	datasets	dataset	NOUN
futech-391	218	7	using	use	VERB
futech-391	218	8	ensemble	ensemble	ADJ
futech-391	218	9	machine	machine	NOUN
futech-391	218	10	learning	learn	VERB
futech-391	218	11	algorithms	algorithms	NOUN
futech-391	218	12	addresses	address	VERB
futech-391	218	13	the	the	DET
futech-391	218	14	core	core	NOUN
futech-391	218	15	issues	issue	NOUN
futech-391	218	16	associated	associate	VERB
futech-391	218	17	with	with	ADP
futech-391	218	18	single	single	ADJ
futech-391	218	19	-	-	PUNCT
futech-391	218	20	platform	platform	NOUN
futech-391	218	21	analyses	analysis	NOUN
futech-391	218	22	,	,	PUNCT
futech-391	218	23	which	which	PRON
futech-391	218	24	overlook	overlook	VERB
futech-391	218	25	critical	critical	ADJ
futech-391	218	26	inter	inter	ADJ
futech-391	218	27	-	-	ADJ
futech-391	218	28	platform	platform	ADJ
futech-391	218	29	correlations	correlation	NOUN
futech-391	218	30	and	and	CCONJ
futech-391	218	31	biomarker	biomarker	VERB
futech-391	218	32	interactions	interaction	NOUN
futech-391	218	33	relevant	relevant	ADJ
futech-391	218	34	to	to	ADP
futech-391	218	35	cross	cross	ADJ
futech-391	218	36	-	-	ADJ
futech-391	218	37	platform	platform	ADJ
futech-391	218	38	analysis	analysis	NOUN
futech-391	218	39	[	[	X
futech-391	218	40	14	14	NUM
futech-391	218	41	]	]	PUNCT
futech-391	218	42	.	.	PUNCT
futech-391	219	1	this	this	DET
futech-391	219	2	type	type	NOUN
futech-391	219	3	of	of	ADP
futech-391	219	4	analysis	analysis	NOUN
futech-391	219	5	is	be	AUX
futech-391	219	6	more	more	ADV
futech-391	219	7	comprehensive	comprehensive	ADJ
futech-391	219	8	and	and	CCONJ
futech-391	219	9	sophisticated	sophisticated	ADJ
futech-391	219	10	than	than	ADP
futech-391	219	11	traditional	traditional	ADJ
futech-391	219	12	statistical	statistical	ADJ
futech-391	219	13	approaches	approach	NOUN
futech-391	219	14	,	,	PUNCT
futech-391	219	15	as	as	SCONJ
futech-391	219	16	it	it	PRON
futech-391	219	17	surpasses	surpass	VERB
futech-391	219	18	the	the	DET
futech-391	219	19	predictive	predictive	ADJ
futech-391	219	20	strength	strength	NOUN
futech-391	219	21	of	of	ADP
futech-391	219	22	such	such	ADJ
futech-391	219	23	methods	method	NOUN
futech-391	219	24	following	follow	VERB
futech-391	219	25	modern	modern	ADJ
futech-391	219	26	clinical	clinical	ADJ
futech-391	219	27	benchmarks	benchmark	NOUN
futech-391	219	28	,	,	PUNCT
futech-391	219	29	achieving	achieve	VERB
futech-391	219	30	levels	level	NOUN
futech-391	219	31	of	of	ADP
futech-391	219	32	diagnostic	diagnostic	ADJ
futech-391	219	33	figure	figure	NOUN
futech-391	219	34	5	5	NUM
futech-391	219	35	.	.	PUNCT
futech-391	219	36	comprehensive	comprehensive	ADJ
futech-391	219	37	analysis	analysis	NOUN
futech-391	219	38	of	of	ADP
futech-391	219	39	tubular	tubular	ADJ
futech-391	219	40	epithelial	epithelial	ADJ
futech-391	219	41	cell	cell	NOUN
futech-391	219	42	-	-	PUNCT
futech-391	219	43	specific	specific	ADJ
futech-391	219	44	biomarkers	biomarker	NOUN
futech-391	219	45	in	in	ADP
futech-391	219	46	diabetic	diabetic	ADJ
futech-391	219	47	nephropathy	nephropathy	NOUN
futech-391	219	48	.	.	PUNCT
futech-391	220	1	(	(	PUNCT
futech-391	220	2	a	a	X
futech-391	220	3	)	)	PUNCT
futech-391	220	4	expression	expression	NOUN
futech-391	220	5	patterns	pattern	NOUN
futech-391	220	6	across	across	ADP
futech-391	220	7	disease	disease	PROPN
futech-391	220	8	stages,(b	stages,(b	PROPN
futech-391	220	9	)	)	PUNCT
futech-391	220	10	roc	roc	PROPN
futech-391	220	11	curves	curve	NOUN
futech-391	220	12	:	:	PUNCT
futech-391	220	13	novel	novel	NOUN
futech-391	220	14	vs	vs	ADP
futech-391	220	15	traditional	traditional	ADJ
futech-391	220	16	biomarkers,(c	biomarkers,(c	NOUN
futech-391	220	17	)	)	PUNCT
futech-391	220	18	clinical	clinical	ADJ
futech-391	220	19	validation	validation	NOUN
futech-391	220	20	in	in	ADP
futech-391	220	21	independent	independent	ADJ
futech-391	220	22	cohorts	cohort	NOUN
futech-391	220	23	,	,	PUNCT
futech-391	220	24	(	(	PUNCT
futech-391	220	25	d	d	X
futech-391	220	26	)	)	PUNCT
futech-391	220	27	functional	functional	ADJ
futech-391	220	28	enrichment	enrichment	NOUN
futech-391	220	29	analysis	analysis	NOUN
futech-391	220	30	w.	w.	PROPN
futech-391	220	31	li	li	PROPN
futech-391	220	32	&	&	CCONJ
futech-391	220	33	sp	sp	PROPN
futech-391	220	34	.	.	PROPN
futech-391	220	35	chandran	chandran	PROPN
futech-391	220	36	/future	/future	PUNCT
futech-391	220	37	technology	technology	PROPN
futech-391	220	38	august	august	PROPN
futech-391	220	39	2025|	2025|	NUM
futech-391	221	1	volume	volume	NOUN
futech-391	221	2	04	04	NUM
futech-391	222	1	|	|	NOUN
futech-391	222	2	issue	issue	NOUN
futech-391	222	3	03	03	NUM
futech-391	223	1	|	|	ADV
futech-391	223	2	pages	page	NOUN
futech-391	223	3	193	193	NUM
futech-391	223	4	-	-	SYM
futech-391	223	5	203	203	NUM
futech-391	223	6	201	201	NUM
futech-391	223	7	accuracy	accuracy	NOUN
futech-391	223	8	that	that	PRON
futech-391	223	9	far	far	ADV
futech-391	223	10	exceed	exceed	VERB
futech-391	223	11	serum	serum	NOUN
futech-391	223	12	creatinine	creatinine	NOUN
futech-391	223	13	and	and	CCONJ
futech-391	223	14	albumin	albumin	NOUN
futech-391	223	15	-	-	PUNCT
futech-391	223	16	tocreatinine	tocreatinine	NOUN
futech-391	223	17	ratio	ratio	NOUN
futech-391	223	18	[	[	X
futech-391	223	19	15	15	NUM
futech-391	223	20	]	]	PUNCT
futech-391	223	21	.	.	PUNCT
futech-391	224	1	ensemble	ensemble	ADJ
futech-391	224	2	learning	learning	NOUN
futech-391	224	3	combines	combine	VERB
futech-391	224	4	the	the	DET
futech-391	224	5	diverse	diverse	ADJ
futech-391	224	6	advantages	advantage	NOUN
futech-391	224	7	offered	offer	VERB
futech-391	224	8	by	by	ADP
futech-391	224	9	random	random	ADJ
futech-391	224	10	forest	forest	NOUN
futech-391	224	11	,	,	PUNCT
futech-391	224	12	support	support	VERB
futech-391	224	13	vector	vector	NOUN
futech-391	224	14	machine	machine	NOUN
futech-391	224	15	,	,	PUNCT
futech-391	224	16	and	and	CCONJ
futech-391	225	1	xgboost	xgboost	ADV
futech-391	225	2	efficiently	efficiently	ADV
futech-391	225	3	so	so	SCONJ
futech-391	225	4	that	that	SCONJ
futech-391	225	5	the	the	DET
futech-391	225	6	resultant	resultant	NOUN
futech-391	225	7	feature	feature	NOUN
futech-391	225	8	selection	selection	NOUN
futech-391	225	9	improves	improve	VERB
futech-391	225	10	the	the	DET
futech-391	225	11	generalisability	generalisability	NOUN
futech-391	225	12	of	of	ADP
futech-391	225	13	the	the	DET
futech-391	225	14	model	model	NOUN
futech-391	225	15	to	to	PART
futech-391	225	16	equitably	equitably	ADV
futech-391	225	17	represent	represent	VERB
futech-391	225	18	numerous	numerous	ADJ
futech-391	225	19	clinical	clinical	ADJ
futech-391	225	20	patients	patient	NOUN
futech-391	225	21	.	.	PUNCT
futech-391	226	1	the	the	DET
futech-391	226	2	application	application	NOUN
futech-391	226	3	of	of	ADP
futech-391	226	4	stringent	stringent	ADJ
futech-391	226	5	batch	batch	NOUN
futech-391	226	6	effect	effect	NOUN
futech-391	226	7	and	and	CCONJ
futech-391	226	8	normalisation	normalisation	NOUN
futech-391	226	9	measures	measure	NOUN
futech-391	226	10	guarantees	guarantee	VERB
futech-391	226	11	data	datum	NOUN
futech-391	226	12	quality	quality	NOUN
futech-391	226	13	and	and	CCONJ
futech-391	226	14	coherence	coherence	NOUN
futech-391	226	15	across	across	ADP
futech-391	226	16	experimental	experimental	ADJ
futech-391	226	17	platforms	platform	NOUN
futech-391	226	18	,	,	PUNCT
futech-391	226	19	laying	lay	VERB
futech-391	226	20	strong	strong	ADJ
futech-391	226	21	foundations	foundation	NOUN
futech-391	226	22	for	for	ADP
futech-391	226	23	subsequent	subsequent	ADJ
futech-391	226	24	computational	computational	ADJ
futech-391	226	25	analyses	analysis	NOUN
futech-391	226	26	,	,	PUNCT
futech-391	226	27	which	which	PRON
futech-391	226	28	enhance	enhance	VERB
futech-391	226	29	post	post	ADJ
futech-391	226	30	-	-	ADJ
futech-391	226	31	hoc	hoc	ADJ
futech-391	226	32	credibility	credibility	NOUN
futech-391	226	33	on	on	ADP
futech-391	226	34	sifts	sift	NOUN
futech-391	226	35	of	of	ADP
futech-391	226	36	data	datum	NOUN
futech-391	226	37	collected	collect	VERB
futech-391	226	38	under	under	ADP
futech-391	226	39	different	different	ADJ
futech-391	226	40	conditions	condition	NOUN
futech-391	226	41	[	[	X
futech-391	226	42	30	30	NUM
futech-391	226	43	]	]	PUNCT
futech-391	226	44	.	.	PUNCT
futech-391	227	1	these	these	DET
futech-391	227	2	techniques	technique	NOUN
futech-391	227	3	provided	provide	VERB
futech-391	227	4	further	further	ADJ
futech-391	227	5	progress	progress	NOUN
futech-391	227	6	towards	towards	ADP
futech-391	227	7	precision	precision	NOUN
futech-391	227	8	medicine	medicine	NOUN
futech-391	227	9	for	for	ADP
futech-391	227	10	kidney	kidney	NOUN
futech-391	227	11	diseases	disease	NOUN
futech-391	227	12	by	by	ADP
futech-391	227	13	facilitating	facilitate	VERB
futech-391	227	14	the	the	DET
futech-391	227	15	application	application	NOUN
futech-391	227	16	of	of	ADP
futech-391	227	17	artificial	artificial	ADJ
futech-391	227	18	intelligence	intelligence	NOUN
futech-391	227	19	for	for	ADP
futech-391	227	20	affording	afford	VERB
futech-391	227	21	complex	complex	ADJ
futech-391	227	22	disease	disease	NOUN
futech-391	227	23	biomarker	biomarker	NOUN
futech-391	227	24	identification	identification	NOUN
futech-391	227	25	.	.	PUNCT
futech-391	228	1	the	the	DET
futech-391	228	2	clinical	clinical	ADJ
futech-391	228	3	translation	translation	NOUN
futech-391	228	4	potential	potential	NOUN
futech-391	228	5	of	of	ADP
futech-391	228	6	discovered	discover	VERB
futech-391	228	7	biomarkers	biomarker	NOUN
futech-391	228	8	goes	go	VERB
futech-391	228	9	beyond	beyond	ADP
futech-391	228	10	simple	simple	ADJ
futech-391	228	11	diagnostics	diagnostic	NOUN
futech-391	228	12	to	to	PART
futech-391	228	13	include	include	VERB
futech-391	228	14	therapy	therapy	NOUN
futech-391	228	15	tracking	tracking	NOUN
futech-391	228	16	and	and	CCONJ
futech-391	228	17	tailored	tailor	VERB
futech-391	228	18	treatment	treatment	NOUN
futech-391	228	19	approaches	approach	NOUN
futech-391	228	20	for	for	ADP
futech-391	228	21	managing	manage	VERB
futech-391	228	22	diabetic	diabetic	ADJ
futech-391	228	23	kidney	kidney	NOUN
futech-391	228	24	disease	disease	NOUN
futech-391	228	25	.	.	PUNCT
futech-391	229	1	the	the	DET
futech-391	229	2	tubular	tubular	ADJ
futech-391	229	3	epithelial	epithelial	ADJ
futech-391	229	4	cellspecific	cellspecific	NOUN
futech-391	229	5	markers	marker	NOUN
futech-391	229	6	showed	show	VERB
futech-391	229	7	much	much	ADJ
futech-391	229	8	superior	superior	ADJ
futech-391	229	9	diagnostic	diagnostic	ADJ
futech-391	229	10	accuracy	accuracy	NOUN
futech-391	229	11	,	,	PUNCT
futech-391	229	12	which	which	PRON
futech-391	229	13	indicates	indicate	VERB
futech-391	229	14	their	their	PRON
futech-391	229	15	possible	possible	ADJ
futech-391	229	16	use	use	NOUN
futech-391	229	17	for	for	ADP
futech-391	229	18	early	early	ADJ
futech-391	229	19	disease	disease	NOUN
futech-391	229	20	intervention	intervention	NOUN
futech-391	229	21	in	in	ADP
futech-391	229	22	high	high	ADJ
futech-391	229	23	-	-	PUNCT
futech-391	229	24	risk	risk	NOUN
futech-391	229	25	groups	group	NOUN
futech-391	229	26	,	,	PUNCT
futech-391	229	27	especially	especially	ADV
futech-391	229	28	during	during	ADP
futech-391	229	29	preclinical	preclinical	ADJ
futech-391	229	30	phases	phase	NOUN
futech-391	229	31	when	when	SCONJ
futech-391	229	32	other	other	ADJ
futech-391	229	33	markers	marker	NOUN
futech-391	229	34	are	be	AUX
futech-391	229	35	still	still	ADV
futech-391	229	36	within	within	ADP
futech-391	229	37	the	the	DET
futech-391	229	38	normal	normal	ADJ
futech-391	229	39	range	range	NOUN
futech-391	229	40	[	[	X
futech-391	229	41	31	31	NUM
futech-391	229	42	]	]	PUNCT
futech-391	229	43	.	.	PUNCT
futech-391	230	1	this	this	DET
futech-391	230	2	improved	improved	ADJ
futech-391	230	3	specificity	specificity	NOUN
futech-391	230	4	might	might	AUX
futech-391	230	5	allow	allow	VERB
futech-391	230	6	starting	start	VERB
futech-391	230	7	timely	timely	ADJ
futech-391	230	8	intervention	intervention	NOUN
futech-391	230	9	with	with	ADP
futech-391	230	10	renoprotective	renoprotective	ADJ
futech-391	230	11	therapy	therapy	NOUN
futech-391	230	12	,	,	PUNCT
futech-391	230	13	like	like	ADP
futech-391	230	14	sglt2	sglt2	NOUN
futech-391	230	15	and	and	CCONJ
futech-391	230	16	ace	ace	VERB
futech-391	230	17	inhibitors	inhibitor	NOUN
futech-391	230	18	,	,	PUNCT
futech-391	230	19	which	which	PRON
futech-391	230	20	are	be	AUX
futech-391	230	21	proven	prove	VERB
futech-391	230	22	to	to	PART
futech-391	230	23	effectively	effectively	ADV
futech-391	230	24	slow	slow	VERB
futech-391	230	25	the	the	DET
futech-391	230	26	progression	progression	NOUN
futech-391	230	27	of	of	ADP
futech-391	230	28	diabetic	diabetic	ADJ
futech-391	230	29	nephropathy	nephropathy	NOUN
futech-391	230	30	when	when	SCONJ
futech-391	230	31	introduced	introduce	VERB
futech-391	230	32	early	early	ADV
futech-391	230	33	in	in	ADP
futech-391	230	34	the	the	DET
futech-391	230	35	disease	disease	NOUN
futech-391	230	36	’	'	PUNCT
futech-391	230	37	s	s	PART
futech-391	230	38	progression	progression	NOUN
futech-391	230	39	[	[	X
futech-391	230	40	32	32	NUM
futech-391	230	41	]	]	PUNCT
futech-391	230	42	.	.	PUNCT
futech-391	231	1	the	the	DET
futech-391	231	2	capability	capability	NOUN
futech-391	231	3	of	of	ADP
futech-391	231	4	the	the	DET
futech-391	231	5	biomarker	biomarker	NOUN
futech-391	231	6	panel	panel	NOUN
futech-391	231	7	to	to	PART
futech-391	231	8	classify	classify	VERB
futech-391	231	9	patients	patient	NOUN
futech-391	231	10	according	accord	VERB
futech-391	231	11	to	to	ADP
futech-391	231	12	the	the	DET
futech-391	231	13	severity	severity	NOUN
futech-391	231	14	of	of	ADP
futech-391	231	15	the	the	DET
futech-391	231	16	disease	disease	NOUN
futech-391	231	17	and	and	CCONJ
futech-391	231	18	risk	risk	NOUN
futech-391	231	19	of	of	ADP
futech-391	231	20	progression	progression	NOUN
futech-391	231	21	enables	enable	VERB
futech-391	231	22	customised	customise	VERB
futech-391	231	23	treatment	treatment	NOUN
futech-391	231	24	strategies	strategy	NOUN
futech-391	231	25	targeting	target	VERB
futech-391	231	26	maximised	maximise	VERB
futech-391	231	27	therapeutic	therapeutic	ADJ
futech-391	231	28	benefit	benefit	NOUN
futech-391	231	29	and	and	CCONJ
futech-391	231	30	minimised	minimise	VERB
futech-391	231	31	adverse	adverse	ADJ
futech-391	231	32	effects	effect	NOUN
futech-391	231	33	[	[	X
futech-391	231	34	6	6	NUM
futech-391	231	35	]	]	PUNCT
futech-391	231	36	.	.	PUNCT
futech-391	232	1	in	in	ADP
futech-391	232	2	addition	addition	NOUN
futech-391	232	3	,	,	PUNCT
futech-391	232	4	the	the	DET
futech-391	232	5	molecular	molecular	ADJ
futech-391	232	6	features	feature	NOUN
futech-391	232	7	detected	detect	VERB
futech-391	232	8	could	could	AUX
futech-391	232	9	be	be	AUX
futech-391	232	10	used	use	VERB
futech-391	232	11	as	as	ADP
futech-391	232	12	dynamic	dynamic	ADJ
futech-391	232	13	biomarkers	biomarker	NOUN
futech-391	232	14	to	to	PART
futech-391	232	15	evaluate	evaluate	VERB
futech-391	232	16	the	the	DET
futech-391	232	17	therapeutic	therapeutic	ADJ
futech-391	232	18	response	response	NOUN
futech-391	232	19	and	and	CCONJ
futech-391	232	20	adjust	adjust	VERB
futech-391	232	21	treatment	treatment	NOUN
futech-391	232	22	strategies	strategy	NOUN
futech-391	232	23	in	in	ADP
futech-391	232	24	day	day	NOUN
futech-391	232	25	-	-	PUNCT
futech-391	232	26	to	to	ADP
futech-391	232	27	-	-	PUNCT
futech-391	232	28	day	day	NOUN
futech-391	232	29	clinical	clinical	ADJ
futech-391	232	30	settings	setting	NOUN
futech-391	232	31	,	,	PUNCT
futech-391	232	32	especially	especially	ADV
futech-391	232	33	regarding	regard	VERB
futech-391	232	34	new	new	ADJ
futech-391	232	35	renoprotective	renoprotective	ADJ
futech-391	232	36	drugs	drug	NOUN
futech-391	232	37	currently	currently	ADV
futech-391	232	38	being	be	AUX
futech-391	232	39	developed	develop	VERB
futech-391	232	40	[	[	PUNCT
futech-391	232	41	33	33	NUM
futech-391	232	42	]	]	PUNCT
futech-391	232	43	.	.	PUNCT
futech-391	233	1	despite	despite	SCONJ
futech-391	233	2	the	the	DET
futech-391	233	3	promising	promising	ADJ
futech-391	233	4	diagnostic	diagnostic	ADJ
futech-391	233	5	performance	performance	NOUN
futech-391	233	6	,	,	PUNCT
futech-391	233	7	clinical	clinical	ADJ
futech-391	233	8	implementation	implementation	NOUN
futech-391	233	9	faces	face	VERB
futech-391	233	10	several	several	ADJ
futech-391	233	11	practical	practical	ADJ
futech-391	233	12	challenges	challenge	NOUN
futech-391	233	13	that	that	PRON
futech-391	233	14	require	require	VERB
futech-391	233	15	consideration	consideration	NOUN
futech-391	233	16	.	.	PUNCT
futech-391	234	1	assay	assay	NOUN
futech-391	234	2	standardization	standardization	NOUN
futech-391	234	3	and	and	CCONJ
futech-391	234	4	interlaboratory	interlaboratory	ADJ
futech-391	234	5	reproducibility	reproducibility	NOUN
futech-391	234	6	remain	remain	VERB
futech-391	234	7	critical	critical	ADJ
futech-391	234	8	concerns	concern	NOUN
futech-391	234	9	for	for	ADP
futech-391	234	10	multiomics	multiomics	NOUN
futech-391	234	11	biomarker	biomarker	NOUN
futech-391	234	12	panels	panel	NOUN
futech-391	234	13	,	,	PUNCT
futech-391	234	14	particularly	particularly	ADV
futech-391	234	15	given	give	VERB
futech-391	234	16	the	the	DET
futech-391	234	17	complexity	complexity	NOUN
futech-391	234	18	of	of	ADP
futech-391	234	19	proteomic	proteomic	ADJ
futech-391	234	20	and	and	CCONJ
futech-391	234	21	metabolomic	metabolomic	ADJ
futech-391	234	22	measurements	measurement	NOUN
futech-391	234	23	across	across	ADP
futech-391	234	24	different	different	ADJ
futech-391	234	25	platforms	platform	NOUN
futech-391	235	1	[	[	X
futech-391	235	2	7	7	NUM
futech-391	235	3	]	]	PUNCT
futech-391	235	4	.	.	PUNCT
futech-391	236	1	cost	cost	NOUN
futech-391	236	2	-	-	PUNCT
futech-391	236	3	effectiveness	effectiveness	NOUN
futech-391	236	4	analysis	analysis	NOUN
futech-391	236	5	will	will	AUX
futech-391	236	6	be	be	AUX
futech-391	236	7	essential	essential	ADJ
futech-391	236	8	,	,	PUNCT
futech-391	236	9	as	as	SCONJ
futech-391	236	10	multi	multi	ADJ
futech-391	236	11	-	-	ADJ
futech-391	236	12	omics	omics	ADJ
futech-391	236	13	profiling	profiling	NOUN
futech-391	236	14	involves	involve	VERB
futech-391	236	15	higher	high	ADJ
futech-391	236	16	expenses	expense	NOUN
futech-391	236	17	than	than	ADP
futech-391	236	18	conventional	conventional	ADJ
futech-391	236	19	markers	marker	NOUN
futech-391	236	20	,	,	PUNCT
futech-391	236	21	necessitating	necessitate	VERB
futech-391	236	22	demonstration	demonstration	NOUN
futech-391	236	23	of	of	ADP
futech-391	236	24	clinical	clinical	ADJ
futech-391	236	25	utility	utility	NOUN
futech-391	236	26	and	and	CCONJ
futech-391	236	27	cost	cost	NOUN
futech-391	236	28	-	-	PUNCT
futech-391	236	29	benefit	benefit	NOUN
futech-391	236	30	ratios	ratio	NOUN
futech-391	236	31	for	for	ADP
futech-391	236	32	healthcare	healthcare	NOUN
futech-391	236	33	adoption	adoption	NOUN
futech-391	236	34	.	.	PUNCT
futech-391	237	1	data	datum	NOUN
futech-391	237	2	acquisition	acquisition	NOUN
futech-391	237	3	limitations	limitation	NOUN
futech-391	237	4	include	include	VERB
futech-391	237	5	the	the	DET
futech-391	237	6	need	need	NOUN
futech-391	237	7	for	for	ADP
futech-391	237	8	specialized	specialized	ADJ
futech-391	237	9	equipment	equipment	NOUN
futech-391	237	10	,	,	PUNCT
futech-391	237	11	trained	train	VERB
futech-391	237	12	personnel	personnel	NOUN
futech-391	237	13	,	,	PUNCT
futech-391	237	14	and	and	CCONJ
futech-391	237	15	standardized	standardized	ADJ
futech-391	237	16	sample	sample	NOUN
futech-391	237	17	processing	processing	NOUN
futech-391	237	18	protocols	protocol	NOUN
futech-391	237	19	that	that	PRON
futech-391	237	20	may	may	AUX
futech-391	237	21	not	not	PART
futech-391	237	22	be	be	AUX
futech-391	237	23	readily	readily	ADV
futech-391	237	24	available	available	ADJ
futech-391	237	25	in	in	ADP
futech-391	237	26	all	all	DET
futech-391	237	27	clinical	clinical	ADJ
futech-391	237	28	settings	setting	NOUN
futech-391	237	29	[	[	X
futech-391	237	30	34	34	NUM
futech-391	237	31	]	]	PUNCT
futech-391	237	32	.	.	PUNCT
futech-391	238	1	furthermore	furthermore	ADV
futech-391	238	2	,	,	PUNCT
futech-391	238	3	integration	integration	NOUN
futech-391	238	4	with	with	ADP
futech-391	238	5	existing	exist	VERB
futech-391	238	6	electronic	electronic	ADJ
futech-391	238	7	health	health	NOUN
futech-391	238	8	records	record	NOUN
futech-391	238	9	and	and	CCONJ
futech-391	238	10	clinical	clinical	ADJ
futech-391	238	11	decision	decision	NOUN
futech-391	238	12	support	support	NOUN
futech-391	238	13	systems	system	NOUN
futech-391	238	14	requires	require	VERB
futech-391	238	15	a	a	DET
futech-391	238	16	robust	robust	ADJ
futech-391	238	17	bioinformatics	bioinformatics	NOUN
futech-391	238	18	infrastructure	infrastructure	NOUN
futech-391	238	19	and	and	CCONJ
futech-391	238	20	user	user	NOUN
futech-391	238	21	-	-	PUNCT
futech-391	238	22	friendly	friendly	ADJ
futech-391	238	23	interfaces	interface	NOUN
futech-391	238	24	to	to	PART
futech-391	238	25	facilitate	facilitate	VERB
futech-391	238	26	routine	routine	ADJ
futech-391	238	27	clinical	clinical	ADJ
futech-391	238	28	use	use	NOUN
futech-391	238	29	by	by	ADP
futech-391	238	30	healthcare	healthcare	NOUN
futech-391	238	31	providers	provider	NOUN
futech-391	238	32	[	[	X
futech-391	238	33	20	20	NUM
futech-391	238	34	]	]	PUNCT
futech-391	238	35	.	.	PUNCT
futech-391	239	1	regardless	regardless	ADV
futech-391	239	2	of	of	ADP
futech-391	239	3	the	the	DET
futech-391	239	4	optimistic	optimistic	ADJ
futech-391	239	5	outcomes	outcome	NOUN
futech-391	239	6	of	of	ADP
futech-391	239	7	the	the	DET
futech-391	239	8	study	study	NOUN
futech-391	239	9	,	,	PUNCT
futech-391	239	10	there	there	PRON
futech-391	239	11	are	be	VERB
futech-391	239	12	relevant	relevant	ADJ
futech-391	239	13	gaps	gap	NOUN
futech-391	239	14	that	that	PRON
futech-391	239	15	merit	merit	VERB
futech-391	239	16	attention	attention	NOUN
futech-391	239	17	concerning	concern	VERB
futech-391	239	18	the	the	DET
futech-391	239	19	study	study	NOUN
futech-391	239	20	’s	’s	PART
futech-391	239	21	conclusions	conclusion	NOUN
futech-391	239	22	and	and	CCONJ
futech-391	239	23	approaches	approach	NOUN
futech-391	239	24	towards	towards	ADP
futech-391	239	25	further	further	ADJ
futech-391	239	26	investigative	investigative	ADJ
futech-391	239	27	efforts	effort	NOUN
futech-391	239	28	.	.	PUNCT
futech-391	240	1	the	the	DET
futech-391	240	2	consequences	consequence	NOUN
futech-391	240	3	stemming	stem	VERB
futech-391	240	4	from	from	ADP
futech-391	240	5	the	the	DET
futech-391	240	6	genetic	genetic	ADJ
futech-391	240	7	background	background	NOUN
futech-391	240	8	,	,	PUNCT
futech-391	240	9	comorbid	comorbid	NOUN
futech-391	240	10	conditions	condition	NOUN
futech-391	240	11	,	,	PUNCT
futech-391	240	12	and	and	CCONJ
futech-391	240	13	even	even	ADV
futech-391	240	14	the	the	DET
futech-391	240	15	environment	environment	NOUN
futech-391	240	16	of	of	ADP
futech-391	240	17	the	the	DET
futech-391	240	18	population	population	NOUN
futech-391	240	19	he	he	PRON
futech-391	240	20	or	or	CCONJ
futech-391	240	21	she	she	PRON
futech-391	240	22	lives	live	VERB
futech-391	240	23	within	within	ADP
futech-391	240	24	tend	tend	NOUN
futech-391	240	25	to	to	PART
futech-391	240	26	affect	affect	VERB
futech-391	240	27	the	the	DET
futech-391	240	28	overall	overall	ADJ
futech-391	240	29	appeal	appeal	NOUN
futech-391	240	30	of	of	ADP
futech-391	240	31	the	the	DET
futech-391	240	32	findings	finding	NOUN
futech-391	240	33	in	in	ADP
futech-391	240	34	relation	relation	NOUN
futech-391	240	35	to	to	ADP
futech-391	240	36	the	the	DET
futech-391	240	37	public	public	NOUN
futech-391	240	38	,	,	PUNCT
futech-391	240	39	which	which	PRON
futech-391	240	40	is	be	AUX
futech-391	240	41	one	one	NUM
futech-391	240	42	of	of	ADP
futech-391	240	43	the	the	DET
futech-391	240	44	concerns	concern	NOUN
futech-391	240	45	with	with	ADP
futech-391	240	46	using	use	VERB
futech-391	240	47	public	public	ADJ
futech-391	240	48	repositories	repository	NOUN
futech-391	240	49	[	[	X
futech-391	240	50	35	35	NUM
futech-391	240	51	]	]	PUNCT
futech-391	240	52	.	.	PUNCT
futech-391	241	1	moreover	moreover	ADV
futech-391	241	2	,	,	PUNCT
futech-391	241	3	the	the	DET
futech-391	241	4	repositories	repository	NOUN
futech-391	241	5	themselves	themselves	PRON
futech-391	241	6	may	may	AUX
futech-391	241	7	pose	pose	VERB
futech-391	241	8	additional	additional	ADJ
futech-391	241	9	selection	selection	NOUN
futech-391	241	10	bias	bias	NOUN
futech-391	241	11	issues	issue	NOUN
futech-391	241	12	ascribed	ascribe	VERB
futech-391	241	13	to	to	ADP
futech-391	241	14	their	their	PRON
futech-391	241	15	very	very	ADJ
futech-391	241	16	nature	nature	NOUN
futech-391	241	17	,	,	PUNCT
futech-391	241	18	leading	lead	VERB
futech-391	241	19	to	to	ADP
futech-391	241	20	retrospective	retrospective	ADJ
futech-391	241	21	methods	method	NOUN
futech-391	241	22	collecting	collect	VERB
futech-391	241	23	data	datum	NOUN
futech-391	241	24	.	.	PUNCT
futech-391	242	1	the	the	DET
futech-391	242	2	integrated	integrate	VERB
futech-391	242	3	dataset	dataset	NOUN
futech-391	242	4	's	's	PART
futech-391	242	5	sample	sample	NOUN
futech-391	242	6	size	size	NOUN
futech-391	242	7	is	be	AUX
futech-391	242	8	still	still	ADV
futech-391	242	9	relatively	relatively	ADV
futech-391	242	10	small	small	ADJ
futech-391	242	11	,	,	PUNCT
futech-391	242	12	which	which	PRON
futech-391	242	13	poses	pose	VERB
futech-391	242	14	significant	significant	ADJ
futech-391	242	15	challenges	challenge	NOUN
futech-391	242	16	in	in	ADP
futech-391	242	17	identifying	identify	VERB
futech-391	242	18	even	even	ADV
futech-391	242	19	the	the	DET
futech-391	242	20	most	most	ADV
futech-391	242	21	subtle	subtle	ADJ
futech-391	242	22	biomarkers	biomarker	NOUN
futech-391	242	23	,	,	PUNCT
futech-391	242	24	though	though	SCONJ
futech-391	242	25	enhanced	enhanced	ADJ
futech-391	242	26	regularization	regularization	NOUN
futech-391	242	27	strategies	strategy	NOUN
futech-391	242	28	and	and	CCONJ
futech-391	242	29	nested	nested	ADJ
futech-391	242	30	crossvalidation	crossvalidation	NOUN
futech-391	242	31	helped	helped	AUX
futech-391	242	32	mitigate	mitigate	VERB
futech-391	242	33	overfitting	overfitte	VERB
futech-391	242	34	concerns	concern	NOUN
futech-391	242	35	.	.	PUNCT
futech-391	243	1	because	because	SCONJ
futech-391	243	2	of	of	ADP
futech-391	243	3	this	this	PRON
futech-391	243	4	,	,	PUNCT
futech-391	243	5	smaller	small	ADJ
futech-391	243	6	but	but	CCONJ
futech-391	243	7	clinically	clinically	ADV
futech-391	243	8	significant	significant	ADJ
futech-391	243	9	molecular	molecular	ADJ
futech-391	243	10	signatures	signature	NOUN
futech-391	243	11	could	could	AUX
futech-391	243	12	also	also	ADV
futech-391	243	13	go	go	VERB
futech-391	243	14	undetected	undetected	ADJ
futech-391	243	15	.	.	PUNCT
futech-391	244	1	not	not	PART
futech-391	244	2	to	to	PART
futech-391	244	3	mention	mention	VERB
futech-391	244	4	the	the	DET
futech-391	244	5	limited	limited	ADJ
futech-391	244	6	statistical	statistical	ADJ
futech-391	244	7	power	power	NOUN
futech-391	244	8	that	that	PRON
futech-391	244	9	comes	come	VERB
futech-391	244	10	with	with	ADP
futech-391	244	11	it	it	PRON
futech-391	244	12	.	.	PUNCT
futech-391	245	1	additionally	additionally	ADV
futech-391	245	2	,	,	PUNCT
futech-391	245	3	the	the	DET
futech-391	245	4	crosssectional	crosssectional	ADJ
futech-391	245	5	design	design	NOUN
futech-391	245	6	prevents	prevent	VERB
futech-391	245	7	assessment	assessment	NOUN
futech-391	245	8	of	of	ADP
futech-391	245	9	temporal	temporal	ADJ
futech-391	245	10	relationships	relationship	NOUN
futech-391	245	11	between	between	ADP
futech-391	245	12	biomarker	biomarker	NOUN
futech-391	245	13	expression	expression	NOUN
futech-391	245	14	patterns	pattern	NOUN
futech-391	245	15	and	and	CCONJ
futech-391	245	16	disease	disease	NOUN
futech-391	245	17	progression	progression	NOUN
futech-391	245	18	trajectories	trajectory	NOUN
futech-391	245	19	,	,	PUNCT
futech-391	245	20	which	which	PRON
futech-391	245	21	are	be	AUX
futech-391	245	22	crucial	crucial	ADJ
futech-391	245	23	for	for	ADP
futech-391	245	24	establishing	establish	VERB
futech-391	245	25	causality	causality	NOUN
futech-391	245	26	and	and	CCONJ
futech-391	245	27	prognostic	prognostic	ADJ
futech-391	245	28	utility	utility	NOUN
futech-391	245	29	[	[	X
futech-391	245	30	36	36	NUM
futech-391	245	31	]	]	PUNCT
futech-391	245	32	.	.	PUNCT
futech-391	246	1	the	the	DET
futech-391	246	2	absence	absence	NOUN
futech-391	246	3	of	of	ADP
futech-391	246	4	longitudinal	longitudinal	ADJ
futech-391	246	5	follow	follow	NOUN
futech-391	246	6	-	-	PUNCT
futech-391	246	7	up	up	NOUN
futech-391	246	8	data	datum	NOUN
futech-391	246	9	limits	limit	NOUN
futech-391	246	10	evaluation	evaluation	NOUN
futech-391	246	11	of	of	ADP
futech-391	246	12	biomarker	biomarker	NOUN
futech-391	246	13	performance	performance	NOUN
futech-391	246	14	for	for	ADP
futech-391	246	15	predicting	predict	VERB
futech-391	246	16	clinical	clinical	ADJ
futech-391	246	17	endpoints	endpoint	NOUN
futech-391	246	18	such	such	ADJ
futech-391	246	19	as	as	ADP
futech-391	246	20	endstage	endstage	NOUN
futech-391	246	21	renal	renal	ADJ
futech-391	246	22	disease	disease	NOUN
futech-391	246	23	,	,	PUNCT
futech-391	246	24	cardiovascular	cardiovascular	ADJ
futech-391	246	25	events	event	NOUN
futech-391	246	26	,	,	PUNCT
futech-391	246	27	and	and	CCONJ
futech-391	246	28	mortality	mortality	NOUN
futech-391	246	29	outcomes	outcome	NOUN
futech-391	246	30	that	that	PRON
futech-391	246	31	are	be	AUX
futech-391	246	32	central	central	ADJ
futech-391	246	33	to	to	ADP
futech-391	246	34	diabetic	diabetic	ADJ
futech-391	246	35	nephropathy	nephropathy	ADJ
futech-391	246	36	management	management	NOUN
futech-391	246	37	decisions	decision	NOUN
futech-391	246	38	[	[	X
futech-391	246	39	40	40	NUM
futech-391	246	40	]	]	PUNCT
futech-391	246	41	.	.	PUNCT
futech-391	247	1	future	future	ADJ
futech-391	247	2	research	research	NOUN
futech-391	247	3	endeavors	endeavor	NOUN
futech-391	247	4	should	should	AUX
futech-391	247	5	prioritize	prioritize	VERB
futech-391	247	6	prospective	prospective	ADJ
futech-391	247	7	validation	validation	NOUN
futech-391	247	8	studies	study	NOUN
futech-391	247	9	in	in	ADP
futech-391	247	10	large	large	ADJ
futech-391	247	11	,	,	PUNCT
futech-391	247	12	diverse	diverse	ADJ
futech-391	247	13	patient	patient	NOUN
futech-391	247	14	cohorts	cohort	NOUN
futech-391	247	15	to	to	PART
futech-391	247	16	confirm	confirm	VERB
futech-391	247	17	the	the	DET
futech-391	247	18	clinical	clinical	ADJ
futech-391	247	19	utility	utility	NOUN
futech-391	247	20	and	and	CCONJ
futech-391	247	21	generalizability	generalizability	NOUN
futech-391	247	22	of	of	ADP
futech-391	247	23	identified	identify	VERB
futech-391	247	24	biomarkers	biomarker	NOUN
futech-391	247	25	across	across	ADP
futech-391	247	26	different	different	ADJ
futech-391	247	27	populations	population	NOUN
futech-391	247	28	and	and	CCONJ
futech-391	247	29	healthcare	healthcare	NOUN
futech-391	247	30	settings	setting	NOUN
futech-391	247	31	.	.	PUNCT
futech-391	248	1	longitudinal	longitudinal	ADJ
futech-391	248	2	studies	study	NOUN
futech-391	248	3	with	with	ADP
futech-391	248	4	extended	extended	ADJ
futech-391	248	5	follow	follow	NOUN
futech-391	248	6	-	-	PUNCT
futech-391	248	7	up	up	ADP
futech-391	248	8	periods	period	NOUN
futech-391	248	9	are	be	AUX
futech-391	248	10	essential	essential	ADJ
futech-391	248	11	for	for	ADP
futech-391	248	12	establishing	establish	VERB
futech-391	248	13	the	the	DET
futech-391	248	14	prognostic	prognostic	ADJ
futech-391	248	15	value	value	NOUN
futech-391	248	16	of	of	ADP
futech-391	248	17	tubular	tubular	ADJ
futech-391	248	18	epithelial	epithelial	ADJ
futech-391	248	19	cell	cell	NOUN
futech-391	248	20	-	-	PUNCT
futech-391	248	21	specific	specific	ADJ
futech-391	248	22	markers	marker	NOUN
futech-391	248	23	and	and	CCONJ
futech-391	248	24	their	their	PRON
futech-391	248	25	utility	utility	NOUN
futech-391	248	26	for	for	ADP
futech-391	248	27	monitoring	monitor	VERB
futech-391	248	28	disease	disease	NOUN
futech-391	248	29	progression	progression	NOUN
futech-391	248	30	and	and	CCONJ
futech-391	248	31	therapeutic	therapeutic	ADJ
futech-391	248	32	responses	response	NOUN
futech-391	248	33	[	[	X
futech-391	248	34	37	37	NUM
futech-391	248	35	]	]	PUNCT
futech-391	248	36	.	.	PUNCT
futech-391	249	1	integration	integration	NOUN
futech-391	249	2	of	of	ADP
futech-391	249	3	additional	additional	ADJ
futech-391	249	4	omics	omic	NOUN
futech-391	249	5	platforms	platform	NOUN
futech-391	249	6	,	,	PUNCT
futech-391	249	7	including	include	VERB
futech-391	249	8	epigenomics	epigenomic	NOUN
futech-391	249	9	and	and	CCONJ
futech-391	249	10	lipidomics	lipidomic	NOUN
futech-391	249	11	,	,	PUNCT
futech-391	249	12	may	may	AUX
futech-391	249	13	provide	provide	VERB
futech-391	249	14	complementary	complementary	ADJ
futech-391	249	15	insights	insight	NOUN
futech-391	249	16	into	into	ADP
futech-391	249	17	diabetic	diabetic	ADJ
futech-391	249	18	nephropathy	nephropathy	ADJ
futech-391	249	19	pathophysiology	pathophysiology	NOUN
futech-391	249	20	and	and	CCONJ
futech-391	249	21	enhance	enhance	VERB
futech-391	249	22	biomarker	biomarker	NOUN
futech-391	249	23	discovery	discovery	NOUN
futech-391	249	24	efforts	effort	NOUN
futech-391	249	25	[	[	PUNCT
futech-391	249	26	38	38	NUM
futech-391	249	27	]	]	PUNCT
futech-391	249	28	.	.	PUNCT
futech-391	250	1	standardized	standardize	VERB
futech-391	250	2	analytical	analytical	ADJ
futech-391	250	3	methods	method	NOUN
futech-391	250	4	and	and	CCONJ
futech-391	250	5	reference	reference	NOUN
futech-391	250	6	materials	material	NOUN
futech-391	250	7	preparation	preparation	NOUN
futech-391	250	8	will	will	AUX
futech-391	250	9	be	be	AUX
futech-391	250	10	most	most	ADV
futech-391	250	11	critical	critical	ADJ
futech-391	250	12	for	for	ADP
futech-391	250	13	facilitating	facilitate	VERB
futech-391	250	14	clinical	clinical	ADJ
futech-391	250	15	application	application	NOUN
futech-391	250	16	and	and	CCONJ
futech-391	250	17	reproducibility	reproducibility	NOUN
futech-391	250	18	across	across	ADP
futech-391	250	19	different	different	ADJ
futech-391	250	20	laboratories	laboratory	NOUN
futech-391	250	21	and	and	CCONJ
futech-391	250	22	healthcare	healthcare	NOUN
futech-391	250	23	systems	system	NOUN
futech-391	250	24	[	[	X
futech-391	250	25	34	34	NUM
futech-391	250	26	]	]	PUNCT
futech-391	250	27	.	.	PUNCT
futech-391	251	1	furthermore	furthermore	ADV
futech-391	251	2	,	,	PUNCT
futech-391	251	3	investigation	investigation	NOUN
futech-391	251	4	of	of	ADP
futech-391	251	5	mechanistic	mechanistic	ADJ
futech-391	251	6	interactions	interaction	NOUN
futech-391	251	7	between	between	ADP
futech-391	251	8	identified	identify	VERB
futech-391	251	9	biomarkers	biomarker	NOUN
futech-391	251	10	and	and	CCONJ
futech-391	251	11	treatment	treatment	NOUN
futech-391	251	12	targets	target	NOUN
futech-391	251	13	would	would	AUX
futech-391	251	14	reveal	reveal	VERB
futech-391	251	15	novel	novel	ADJ
futech-391	251	16	intervention	intervention	NOUN
futech-391	251	17	strategies	strategy	NOUN
futech-391	251	18	for	for	ADP
futech-391	251	19	the	the	DET
futech-391	251	20	prevention	prevention	NOUN
futech-391	251	21	or	or	CCONJ
futech-391	251	22	reversal	reversal	NOUN
futech-391	251	23	of	of	ADP
futech-391	251	24	diabetic	diabetic	ADJ
futech-391	251	25	kidney	kidney	NOUN
futech-391	251	26	disease	disease	NOUN
futech-391	251	27	tubular	tubular	ADJ
futech-391	251	28	epithelial	epithelial	ADJ
futech-391	251	29	cell	cell	NOUN
futech-391	251	30	dysfunction	dysfunction	NOUN
futech-391	252	1	[	[	X
futech-391	252	2	39	39	NUM
futech-391	252	3	]	]	PUNCT
futech-391	252	4	.	.	PUNCT
futech-391	253	1	these	these	DET
futech-391	253	2	future	future	ADJ
futech-391	253	3	directions	direction	NOUN
futech-391	253	4	will	will	AUX
futech-391	253	5	be	be	AUX
futech-391	253	6	important	important	ADJ
futech-391	253	7	in	in	ADP
futech-391	253	8	bridging	bridge	VERB
futech-391	253	9	current	current	ADJ
futech-391	253	10	research	research	NOUN
futech-391	253	11	findings	finding	NOUN
futech-391	253	12	to	to	ADP
futech-391	253	13	clinically	clinically	ADV
futech-391	253	14	effective	effective	ADJ
futech-391	253	15	tools	tool	NOUN
futech-391	253	16	that	that	PRON
futech-391	253	17	improve	improve	VERB
futech-391	253	18	the	the	DET
futech-391	253	19	outcomes	outcome	NOUN
futech-391	253	20	of	of	ADP
futech-391	253	21	diabetic	diabetic	ADJ
futech-391	253	22	nephropathy	nephropathy	ADJ
futech-391	253	23	patients	patient	NOUN
futech-391	253	24	.	.	PUNCT
futech-391	254	1	5	5	X
futech-391	254	2	.	.	X
futech-391	254	3	conclusion	conclusion	NOUN
futech-391	254	4	this	this	DET
futech-391	254	5	study	study	NOUN
futech-391	254	6	shows	show	VERB
futech-391	254	7	the	the	DET
futech-391	254	8	opportunity	opportunity	NOUN
futech-391	254	9	for	for	SCONJ
futech-391	254	10	machine	machine	NOUN
futech-391	254	11	learningbased	learningbase	VERB
futech-391	254	12	multi	multi	ADJ
futech-391	254	13	-	-	ADJ
futech-391	254	14	omics	omics	ADJ
futech-391	254	15	integration	integration	NOUN
futech-391	254	16	frameworks	framework	NOUN
futech-391	254	17	to	to	PART
futech-391	254	18	automate	automate	VERB
futech-391	254	19	the	the	DET
futech-391	254	20	detection	detection	NOUN
futech-391	254	21	of	of	ADP
futech-391	254	22	diabetic	diabetic	ADJ
futech-391	254	23	nephropathy	nephropathy	NOUN
futech-391	254	24	’s	’s	PART
futech-391	254	25	tubular	tubular	ADJ
futech-391	254	26	epithelial	epithelial	ADJ
futech-391	254	27	cellspecific	cellspecific	NOUN
futech-391	254	28	biomarkers	biomarker	NOUN
futech-391	254	29	,	,	PUNCT
futech-391	254	30	which	which	PRON
futech-391	254	31	equate	equate	VERB
futech-391	254	32	to	to	PART
futech-391	254	33	ten	ten	NUM
futech-391	254	34	candidate	candidate	NOUN
futech-391	254	35	molecules	molecule	NOUN
futech-391	254	36	with	with	ADP
futech-391	254	37	unmatched	unmatched	ADJ
futech-391	254	38	accuracy	accuracy	NOUN
futech-391	254	39	in	in	ADP
futech-391	254	40	diagnosis	diagnosis	NOUN
futech-391	254	41	when	when	SCONJ
futech-391	254	42	juxtaposed	juxtapose	VERB
futech-391	254	43	with	with	ADP
futech-391	254	44	clinical	clinical	ADJ
futech-391	254	45	markers	marker	NOUN
futech-391	254	46	.	.	PUNCT
futech-391	255	1	ensemble	ensemble	ADJ
futech-391	255	2	learning	learning	NOUN
futech-391	255	3	,	,	PUNCT
futech-391	255	4	for	for	ADP
futech-391	255	5	example	example	NOUN
futech-391	255	6	,	,	PUNCT
futech-391	255	7	outperformed	outperform	VERB
futech-391	255	8	traditional	traditional	ADJ
futech-391	255	9	serum	serum	NOUN
futech-391	255	10	creatinine	creatinine	NOUN
futech-391	255	11	and	and	CCONJ
futech-391	255	12	albumin	albumin	NOUN
futech-391	255	13	-	-	PUNCT
futech-391	255	14	tocreatinine	tocreatinine	NOUN
futech-391	255	15	ratio	ratio	NOUN
futech-391	255	16	markers	marker	NOUN
futech-391	255	17	by	by	ADP
futech-391	255	18	30	30	NUM
futech-391	255	19	%	%	NOUN
futech-391	255	20	,	,	PUNCT
futech-391	255	21	secondary	secondary	ADJ
futech-391	255	22	to	to	ADP
futech-391	255	23	classification	classification	NOUN
futech-391	255	24	accuracy	accuracy	NOUN
futech-391	255	25	of	of	ADP
futech-391	255	26	91.4	91.4	NUM
futech-391	255	27	%	%	NOUN
futech-391	255	28	and	and	CCONJ
futech-391	255	29	auc	auc	NOUN
futech-391	255	30	of	of	ADP
futech-391	255	31	0.947	0.947	NUM
futech-391	255	32	.	.	PUNCT
futech-391	256	1	kim-1	kim-1	X
futech-391	256	2	,	,	PUNCT
futech-391	256	3	ngal	ngal	ADJ
futech-391	256	4	,	,	PUNCT
futech-391	256	5	and	and	CCONJ
futech-391	256	6	lfabp	lfabp	NOUN
futech-391	256	7	,	,	PUNCT
futech-391	256	8	alongside	alongside	ADP
futech-391	256	9	seven	seven	NUM
futech-391	256	10	other	other	ADJ
futech-391	256	11	markers	marker	NOUN
futech-391	256	12	,	,	PUNCT
futech-391	256	13	formed	form	VERB
futech-391	256	14	the	the	DET
futech-391	256	15	multicomponent	multicomponent	NOUN
futech-391	256	16	biomarkers	biomarker	NOUN
futech-391	256	17	for	for	ADP
futech-391	256	18	the	the	DET
futech-391	256	19	integrated	integrated	ADJ
futech-391	256	20	signature	signature	NOUN
futech-391	256	21	,	,	PUNCT
futech-391	256	22	which	which	PRON
futech-391	256	23	reflects	reflect	VERB
futech-391	256	24	the	the	DET
futech-391	256	25	advanced	advanced	ADJ
futech-391	256	26	pathophysiology	pathophysiology	NOUN
futech-391	256	27	orchestrated	orchestrate	VERB
futech-391	256	28	by	by	ADP
futech-391	256	29	diabetic	diabetic	ADJ
futech-391	256	30	kidney	kidney	NOUN
futech-391	256	31	disease	disease	NOUN
futech-391	256	32	’s	’s	PART
futech-391	256	33	tubular	tubular	ADJ
futech-391	256	34	epithelial	epithelial	ADJ
futech-391	256	35	cell	cell	NOUN
futech-391	256	36	dysfunction	dysfunction	NOUN
futech-391	256	37	.	.	PUNCT
futech-391	257	1	the	the	DET
futech-391	257	2	stepwise	stepwise	ADJ
futech-391	257	3	expression	expression	NOUN
futech-391	257	4	shift	shift	NOUN
futech-391	257	5	seen	see	VERB
futech-391	257	6	with	with	ADP
futech-391	257	7	the	the	DET
futech-391	257	8	progression	progression	NOUN
futech-391	257	9	of	of	ADP
futech-391	257	10	the	the	DET
futech-391	257	11	disease	disease	NOUN
futech-391	257	12	strengthens	strengthen	VERB
futech-391	257	13	the	the	DET
futech-391	257	14	notion	notion	NOUN
futech-391	257	15	of	of	ADP
futech-391	257	16	tubulointerstitial	tubulointerstitial	ADJ
futech-391	257	17	injury	injury	NOUN
futech-391	257	18	being	be	AUX
futech-391	257	19	a	a	DET
futech-391	257	20	core	core	NOUN
futech-391	257	21	driver	driver	NOUN
futech-391	257	22	of	of	ADP
futech-391	257	23	the	the	DET
futech-391	257	24	diabetic	diabetic	ADJ
futech-391	257	25	nephropathy	nephropathy	ADJ
futech-391	257	26	disease	disease	NOUN
futech-391	257	27	continuum	continuum	ADJ
futech-391	257	28	,	,	PUNCT
futech-391	257	29	developing	develop	VERB
futech-391	257	30	in	in	ADP
futech-391	257	31	a	a	DET
futech-391	257	32	manner	manner	NOUN
futech-391	257	33	that	that	PRON
futech-391	257	34	is	be	AUX
futech-391	257	35	relatively	relatively	ADV
futech-391	257	36	unaffected	unaffected	ADJ
futech-391	257	37	by	by	ADP
futech-391	257	38	damage	damage	NOUN
futech-391	257	39	to	to	ADP
futech-391	257	40	the	the	DET
futech-391	257	41	glomeruli	glomeruli	NOUN
futech-391	257	42	.	.	PUNCT
futech-391	258	1	provided	provide	VERB
futech-391	258	2	text	text	NOUN
futech-391	258	3	outlines	outline	VERB
futech-391	258	4	some	some	PRON
futech-391	258	5	of	of	ADP
futech-391	258	6	the	the	DET
futech-391	258	7	disease	disease	NOUN
futech-391	258	8	’s	’s	PART
futech-391	258	9	most	most	ADV
futech-391	258	10	impactful	impactful	ADJ
futech-391	258	11	mechanisms	mechanism	NOUN
futech-391	258	12	alongside	alongside	ADP
futech-391	258	13	critical	critical	ADJ
futech-391	258	14	inflammatory	inflammatory	ADJ
futech-391	258	15	stress	stress	NOUN
futech-391	258	16	response	response	NOUN
futech-391	258	17	,	,	PUNCT
futech-391	258	18	oxidative	oxidative	ADJ
futech-391	258	19	injury	injury	NOUN
futech-391	258	20	,	,	PUNCT
futech-391	258	21	and	and	CCONJ
futech-391	258	22	epithelial	epithelial	ADJ
futech-391	258	23	-	-	PUNCT
futech-391	258	24	mesenchymal	mesenchymal	NOUN
futech-391	258	25	transition	transition	NOUN
futech-391	258	26	by	by	ADP
futech-391	258	27	detailing	detail	VERB
futech-391	258	28	the	the	DET
futech-391	258	29	disease	disease	NOUN
futech-391	258	30	pathogenesis	pathogenesis	NOUN
futech-391	258	31	and	and	CCONJ
futech-391	258	32	possible	possible	ADJ
futech-391	258	33	intervention	intervention	NOUN
futech-391	258	34	points	point	NOUN
futech-391	258	35	.	.	PUNCT
futech-391	259	1	in	in	ADP
futech-391	259	2	addition	addition	NOUN
futech-391	259	3	to	to	ADP
futech-391	259	4	the	the	DET
futech-391	259	5	diagnostic	diagnostic	ADJ
futech-391	259	6	functionalities	functionality	NOUN
futech-391	259	7	,	,	PUNCT
futech-391	259	8	the	the	DET
futech-391	259	9	clinical	clinical	ADJ
futech-391	259	10	consequences	consequence	NOUN
futech-391	259	11	of	of	ADP
futech-391	259	12	these	these	DET
futech-391	259	13	findings	finding	NOUN
futech-391	259	14	also	also	ADV
futech-391	259	15	include	include	VERB
futech-391	259	16	precision	precision	NOUN
futech-391	259	17	therapy	therapy	NOUN
futech-391	259	18	,	,	PUNCT
futech-391	259	19	more	more	ADV
futech-391	259	20	personalized	personalized	ADJ
futech-391	259	21	treatment	treatment	NOUN
futech-391	259	22	,	,	PUNCT
futech-391	259	23	and	and	CCONJ
futech-391	259	24	adaptive	adaptive	ADJ
futech-391	259	25	monitoring	monitoring	NOUN
futech-391	259	26	approaches	approach	NOUN
futech-391	259	27	for	for	ADP
futech-391	259	28	the	the	DET
futech-391	259	29	management	management	NOUN
futech-391	259	30	of	of	ADP
futech-391	259	31	diabetic	diabetic	ADJ
futech-391	259	32	kidney	kidney	NOUN
futech-391	259	33	disease	disease	NOUN
futech-391	259	34	.	.	PUNCT
futech-391	260	1	the	the	DET
futech-391	260	2	improved	improve	VERB
futech-391	260	3	sensitivity	sensitivity	NOUN
futech-391	260	4	and	and	CCONJ
futech-391	260	5	specificity	specificity	NOUN
futech-391	260	6	ranges	range	VERB
futech-391	260	7	of	of	ADP
futech-391	260	8	tubular	tubular	ADJ
futech-391	260	9	epithelial	epithelial	ADJ
futech-391	260	10	cellw	cellw	NOUN
futech-391	260	11	.	.	PUNCT
futech-391	261	1	li	li	PROPN
futech-391	261	2	&	&	CCONJ
futech-391	261	3	sp	sp	PROPN
futech-391	261	4	.	.	PROPN
futech-391	261	5	chandran	chandran	PROPN
futech-391	261	6	/future	/future	PUNCT
futech-391	261	7	technology	technology	PROPN
futech-391	261	8	august	august	PROPN
futech-391	261	9	2025|	2025|	NUM
futech-391	261	10	volume	volume	NOUN
futech-391	261	11	04	04	NUM
futech-391	262	1	|	|	NOUN
futech-391	262	2	issue	issue	NOUN
futech-391	262	3	03	03	NUM
futech-391	263	1	|	|	ADV
futech-391	263	2	pages	page	NOUN
futech-391	263	3	193	193	NUM
futech-391	263	4	-	-	SYM
futech-391	263	5	203	203	NUM
futech-391	263	6	202	202	NUM
futech-391	263	7	specific	specific	ADJ
futech-391	263	8	biomarkers	biomarker	NOUN
futech-391	263	9	present	present	VERB
futech-391	263	10	the	the	DET
futech-391	263	11	clearest	clear	ADJ
futech-391	263	12	opportunity	opportunity	NOUN
futech-391	263	13	for	for	ADP
futech-391	263	14	early	early	ADJ
futech-391	263	15	clinical	clinical	ADJ
futech-391	263	16	detection	detection	NOUN
futech-391	263	17	,	,	PUNCT
futech-391	263	18	long	long	ADV
futech-391	263	19	before	before	SCONJ
futech-391	263	20	conventional	conventional	ADJ
futech-391	263	21	markers	marker	NOUN
futech-391	263	22	are	be	AUX
futech-391	263	23	able	able	ADJ
futech-391	263	24	to	to	PART
futech-391	263	25	quantify	quantify	VERB
futech-391	263	26	the	the	DET
futech-391	263	27	level	level	NOUN
futech-391	263	28	of	of	ADP
futech-391	263	29	disease	disease	NOUN
futech-391	263	30	progression	progression	NOUN
futech-391	263	31	,	,	PUNCT
futech-391	263	32	allowing	allow	VERB
futech-391	263	33	timely	timely	ADJ
futech-391	263	34	intervention	intervention	NOUN
futech-391	263	35	with	with	ADP
futech-391	263	36	renal	renal	ADJ
futech-391	263	37	protective	protective	ADJ
futech-391	263	38	interventions	intervention	NOUN
futech-391	263	39	.	.	PUNCT
futech-391	264	1	the	the	DET
futech-391	264	2	extensive	extensive	ADJ
futech-391	264	3	validation	validation	NOUN
futech-391	264	4	in	in	ADP
futech-391	264	5	several	several	ADJ
futech-391	264	6	independent	independent	ADJ
futech-391	264	7	cohorts	cohort	NOUN
futech-391	264	8	confirms	confirm	VERB
futech-391	264	9	the	the	DET
futech-391	264	10	reproducibility	reproducibility	NOUN
futech-391	264	11	and	and	CCONJ
futech-391	264	12	clinical	clinical	ADJ
futech-391	264	13	applicability	applicability	NOUN
futech-391	264	14	of	of	ADP
futech-391	264	15	the	the	DET
futech-391	264	16	identified	identify	VERB
futech-391	264	17	biomarkers	biomarker	NOUN
futech-391	264	18	across	across	ADP
futech-391	264	19	different	different	ADJ
futech-391	264	20	populations	population	NOUN
futech-391	264	21	,	,	PUNCT
futech-391	264	22	therefore	therefore	ADV
futech-391	264	23	,	,	PUNCT
futech-391	264	24	affirming	affirm	VERB
futech-391	264	25	the	the	DET
futech-391	264	26	diagnostic	diagnostic	ADJ
futech-391	264	27	credence	credence	NOUN
futech-391	264	28	of	of	ADP
futech-391	264	29	the	the	DET
futech-391	264	30	markers	marker	NOUN
futech-391	264	31	.	.	PUNCT
futech-391	265	1	the	the	DET
futech-391	265	2	authors	author	NOUN
futech-391	265	3	also	also	ADV
futech-391	265	4	note	note	VERB
futech-391	265	5	salient	salient	ADJ
futech-391	265	6	shortcomings	shortcoming	NOUN
futech-391	265	7	,	,	PUNCT
futech-391	265	8	such	such	ADJ
futech-391	265	9	as	as	ADP
futech-391	265	10	the	the	DET
futech-391	265	11	reliance	reliance	NOUN
futech-391	265	12	on	on	ADP
futech-391	265	13	pre	pre	ADJ
futech-391	265	14	-	-	ADJ
futech-391	265	15	collected	collected	ADJ
futech-391	265	16	data	datum	NOUN
futech-391	265	17	and	and	CCONJ
futech-391	265	18	the	the	DET
futech-391	265	19	absence	absence	NOUN
futech-391	265	20	of	of	ADP
futech-391	265	21	pre	pre	ADJ
futech-391	265	22	-	-	VERB
futech-391	265	23	collected	collected	ADJ
futech-391	265	24	,	,	PUNCT
futech-391	265	25	prospective	prospective	ADJ
futech-391	265	26	longitudinal	longitudinal	ADJ
futech-391	265	27	data	datum	NOUN
futech-391	265	28	verification	verification	NOUN
futech-391	265	29	needed	need	VERB
futech-391	265	30	for	for	ADP
futech-391	265	31	establishing	establish	VERB
futech-391	265	32	predictive	predictive	ADJ
futech-391	265	33	value	value	NOUN
futech-391	265	34	,	,	PUNCT
futech-391	265	35	along	along	ADP
futech-391	265	36	with	with	ADP
futech-391	265	37	temporal	temporal	ADJ
futech-391	265	38	connections	connection	NOUN
futech-391	265	39	between	between	ADP
futech-391	265	40	biomarker	biomarker	NOUN
futech-391	265	41	expression	expression	NOUN
futech-391	265	42	and	and	CCONJ
futech-391	265	43	clinical	clinical	ADJ
futech-391	265	44	outcomes	outcome	NOUN
futech-391	265	45	,	,	PUNCT
futech-391	265	46	which	which	PRON
futech-391	265	47	require	require	VERB
futech-391	265	48	temporal	temporal	ADJ
futech-391	265	49	relationships	relationship	NOUN
futech-391	265	50	.	.	PUNCT
futech-391	266	1	future	future	ADJ
futech-391	266	2	research	research	NOUN
futech-391	266	3	endeavors	endeavor	NOUN
futech-391	266	4	should	should	AUX
futech-391	266	5	prioritize	prioritize	VERB
futech-391	266	6	large	large	ADJ
futech-391	266	7	-	-	PUNCT
futech-391	266	8	scale	scale	NOUN
futech-391	266	9	prospective	prospective	ADJ
futech-391	266	10	studies	study	NOUN
futech-391	266	11	,	,	PUNCT
futech-391	266	12	standardization	standardization	NOUN
futech-391	266	13	of	of	ADP
futech-391	266	14	analytical	analytical	ADJ
futech-391	266	15	protocols	protocol	NOUN
futech-391	266	16	,	,	PUNCT
futech-391	266	17	and	and	CCONJ
futech-391	266	18	investigation	investigation	NOUN
futech-391	266	19	of	of	ADP
futech-391	266	20	mechanistic	mechanistic	ADJ
futech-391	266	21	relationships	relationship	NOUN
futech-391	266	22	between	between	ADP
futech-391	266	23	identified	identify	VERB
futech-391	266	24	biomarkers	biomarker	NOUN
futech-391	266	25	and	and	CCONJ
futech-391	266	26	therapeutic	therapeutic	ADJ
futech-391	266	27	targets	target	NOUN
futech-391	266	28	to	to	PART
futech-391	266	29	facilitate	facilitate	VERB
futech-391	266	30	clinical	clinical	ADJ
futech-391	266	31	translation	translation	NOUN
futech-391	266	32	and	and	CCONJ
futech-391	266	33	improve	improve	VERB
futech-391	266	34	outcomes	outcome	NOUN
futech-391	266	35	for	for	ADP
futech-391	266	36	patients	patient	NOUN
futech-391	266	37	with	with	ADP
futech-391	266	38	diabetic	diabetic	ADJ
futech-391	266	39	nephropathy	nephropathy	NOUN
futech-391	266	40	.	.	PUNCT
futech-391	267	1	ethical	ethical	ADJ
futech-391	267	2	issue	issue	NOUN
futech-391	267	3	the	the	DET
futech-391	267	4	authors	author	NOUN
futech-391	267	5	are	be	AUX
futech-391	267	6	aware	aware	ADJ
futech-391	267	7	of	of	ADP
futech-391	267	8	and	and	CCONJ
futech-391	267	9	comply	comply	ADJ
futech-391	267	10	with	with	ADP
futech-391	267	11	best	good	ADJ
futech-391	267	12	practices	practice	NOUN
futech-391	267	13	in	in	ADP
futech-391	267	14	publication	publication	NOUN
futech-391	267	15	ethics	ethic	NOUN
futech-391	267	16	,	,	PUNCT
futech-391	267	17	specifically	specifically	ADV
futech-391	267	18	with	with	ADP
futech-391	267	19	regard	regard	NOUN
futech-391	267	20	to	to	ADP
futech-391	267	21	authorship	authorship	NOUN
futech-391	267	22	(	(	PUNCT
futech-391	267	23	avoidance	avoidance	NOUN
futech-391	267	24	of	of	ADP
futech-391	267	25	guest	guest	NOUN
futech-391	267	26	authorship	authorship	NOUN
futech-391	267	27	)	)	PUNCT
futech-391	267	28	,	,	PUNCT
futech-391	267	29	dual	dual	ADJ
futech-391	267	30	submission	submission	NOUN
futech-391	267	31	,	,	PUNCT
futech-391	267	32	manipulation	manipulation	NOUN
futech-391	267	33	of	of	ADP
futech-391	267	34	figures	figure	NOUN
futech-391	267	35	,	,	PUNCT
futech-391	267	36	competing	compete	VERB
futech-391	267	37	interests	interest	NOUN
futech-391	267	38	,	,	PUNCT
futech-391	267	39	and	and	CCONJ
futech-391	267	40	compliance	compliance	NOUN
futech-391	267	41	with	with	ADP
futech-391	267	42	policies	policy	NOUN
futech-391	267	43	on	on	ADP
futech-391	267	44	research	research	NOUN
futech-391	267	45	ethics	ethic	NOUN
futech-391	267	46	.	.	PUNCT
futech-391	268	1	the	the	DET
futech-391	268	2	author	author	NOUN
futech-391	268	3	adheres	adhere	VERB
futech-391	268	4	to	to	ADP
futech-391	268	5	publication	publication	NOUN
futech-391	268	6	requirements	requirement	NOUN
futech-391	268	7	that	that	SCONJ
futech-391	268	8	the	the	DET
futech-391	268	9	submitted	submit	VERB
futech-391	268	10	work	work	NOUN
futech-391	268	11	is	be	AUX
futech-391	268	12	original	original	ADJ
futech-391	268	13	and	and	CCONJ
futech-391	268	14	has	have	AUX
futech-391	268	15	not	not	PART
futech-391	268	16	been	be	AUX
futech-391	268	17	published	publish	VERB
futech-391	268	18	elsewhere	elsewhere	ADV
futech-391	268	19	.	.	PUNCT
futech-391	269	1	data	datum	NOUN
futech-391	269	2	availability	availability	NOUN
futech-391	269	3	statement	statement	NOUN
futech-391	269	4	the	the	DET
futech-391	269	5	manuscript	manuscript	NOUN
futech-391	269	6	contains	contain	VERB
futech-391	269	7	all	all	DET
futech-391	269	8	the	the	DET
futech-391	269	9	data	datum	NOUN
futech-391	269	10	.	.	PUNCT
futech-391	270	1	however	however	ADV
futech-391	270	2	,	,	PUNCT
futech-391	270	3	more	more	ADJ
futech-391	270	4	data	datum	NOUN
futech-391	270	5	will	will	AUX
futech-391	270	6	be	be	AUX
futech-391	270	7	available	available	ADJ
futech-391	270	8	upon	upon	SCONJ
futech-391	270	9	request	request	NOUN
futech-391	270	10	from	from	ADP
futech-391	270	11	the	the	DET
futech-391	270	12	authors	author	NOUN
futech-391	270	13	.	.	PUNCT
futech-391	271	1	conflict	conflict	NOUN
futech-391	271	2	of	of	ADP
futech-391	271	3	interest	interest	NOUN
futech-391	271	4	the	the	DET
futech-391	271	5	authors	author	NOUN
futech-391	271	6	declare	declare	VERB
futech-391	271	7	no	no	DET
futech-391	271	8	potential	potential	ADJ
futech-391	271	9	conflict	conflict	NOUN
futech-391	271	10	of	of	ADP
futech-391	271	11	interest	interest	NOUN
futech-391	271	12	.	.	PUNCT
futech-391	272	1	references	reference	NOUN
futech-391	272	2	[	[	X
futech-391	272	3	1	1	NUM
futech-391	272	4	]	]	X
futech-391	272	5	y.	y.	PROPN
futech-391	272	6	chen	chen	PROPN
futech-391	272	7	,	,	PUNCT
futech-391	272	8	x.	x.	PROPN
futech-391	272	9	liu	liu	PROPN
futech-391	272	10	,	,	PUNCT
futech-391	272	11	m.	m.	NOUN
futech-391	272	12	shengbu	shengbu	PROPN
futech-391	272	13	,	,	PUNCT
futech-391	272	14	q.	q.	PROPN
futech-391	272	15	shi	shi	PROPN
futech-391	272	16	,	,	PUNCT
futech-391	272	17	s.	s.	PROPN
futech-391	272	18	jiaqiu	jiaqiu	PROPN
futech-391	272	19	,	,	PUNCT
futech-391	272	20	and	and	CCONJ
futech-391	272	21	x.	x.	PROPN
futech-391	272	22	lai	lai	PROPN
futech-391	272	23	,	,	PUNCT
futech-391	272	24	"	"	PUNCT
futech-391	272	25	biomarkers	biomarker	NOUN
futech-391	272	26	:	:	PUNCT
futech-391	272	27	new	new	ADJ
futech-391	272	28	advances	advance	NOUN
futech-391	272	29	in	in	ADP
futech-391	272	30	diabetic	diabetic	ADJ
futech-391	272	31	nephropathy	nephropathy	NOUN
futech-391	272	32	,	,	PUNCT
futech-391	272	33	"	"	PUNCT
futech-391	272	34	natural	natural	ADJ
futech-391	272	35	product	product	NOUN
futech-391	272	36	communications	communication	NOUN
futech-391	272	37	,	,	PUNCT
futech-391	272	38	vol	vol	NOUN
futech-391	272	39	.	.	PROPN
futech-391	272	40	20	20	NUM
futech-391	272	41	,	,	PUNCT
futech-391	272	42	no	no	INTJ
futech-391	272	43	.	.	NOUN
futech-391	272	44	2	2	NUM
futech-391	272	45	,	,	PUNCT
futech-391	272	46	p.	p.	NOUN
futech-391	272	47	1934578x251321758	1934578x251321758	NUM
futech-391	272	48	,	,	PUNCT
futech-391	272	49	2025	2025	NUM
futech-391	272	50	.	.	PUNCT
futech-391	273	1	doi:10.1177/1934578x251321758	doi:10.1177/1934578x251321758	NOUN
futech-391	273	2	.	.	PUNCT
futech-391	274	1	[	[	X
futech-391	274	2	2	2	X
futech-391	274	3	]	]	PUNCT
futech-391	274	4	j.	j.	PROPN
futech-391	274	5	rico	rico	PROPN
futech-391	274	6	-	-	PUNCT
futech-391	274	7	fontalvo	fontalvo	NOUN
futech-391	274	8	et	et	PROPN
futech-391	274	9	al	al	PROPN
futech-391	274	10	.	.	PROPN
futech-391	274	11	,	,	PUNCT
futech-391	274	12	"	"	PUNCT
futech-391	274	13	novel	novel	ADJ
futech-391	274	14	biomarkers	biomarker	NOUN
futech-391	274	15	of	of	ADP
futech-391	274	16	diabetic	diabetic	ADJ
futech-391	274	17	kidney	kidney	NOUN
futech-391	274	18	disease	disease	NOUN
futech-391	274	19	,	,	PUNCT
futech-391	274	20	"	"	PUNCT
futech-391	274	21	biomolecules	biomolecule	NOUN
futech-391	274	22	,	,	PUNCT
futech-391	274	23	vol	vol	NOUN
futech-391	274	24	.	.	PROPN
futech-391	274	25	13	13	NUM
futech-391	274	26	,	,	PUNCT
futech-391	274	27	no	no	INTJ
futech-391	274	28	.	.	NOUN
futech-391	274	29	4	4	NUM
futech-391	274	30	,	,	PUNCT
futech-391	274	31	p.	p.	NOUN
futech-391	274	32	633	633	NUM
futech-391	274	33	,	,	PUNCT
futech-391	274	34	mar	mar	PROPN
futech-391	274	35	31	31	NUM
futech-391	274	36	2023	2023	NUM
futech-391	274	37	.	.	PUNCT
futech-391	275	1	doi	doi	NOUN
futech-391	275	2	:	:	PUNCT
futech-391	275	3	10.3390	10.3390	NUM
futech-391	275	4	/	/	SYM
futech-391	275	5	biom13040633	biom13040633	NOUN
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futech-391	276	3	]	]	PUNCT
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futech-391	278	37	.	.	PUNCT
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futech-391	281	44	,	,	PUNCT
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futech-391	282	1	doi	doi	NOUN
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futech-391	283	37	.	.	PUNCT
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futech-391	291	1	doi	doi	NOUN
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futech-391	292	44	.	.	PUNCT
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futech-391	296	2	-	-	SYM
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futech-391	296	7	.	.	PUNCT
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futech-391	299	9	,	,	PUNCT
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futech-391	299	13	.	.	PUNCT
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futech-391	301	3	]	]	PUNCT
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futech-391	301	17	in	in	ADP
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futech-391	301	30	,	,	PUNCT
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futech-391	303	3	]	]	PUNCT
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futech-391	304	2	-	-	SYM
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futech-391	308	2	-	-	SYM
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futech-391	313	1	doi	doi	NOUN
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futech-391	320	1	liu	liu	PROPN
futech-391	320	2	,	,	PUNCT
futech-391	320	3	and	and	CCONJ
futech-391	320	4	p.	p.	PROPN
futech-391	320	5	wu	wu	PROPN
futech-391	320	6	,	,	PUNCT
futech-391	320	7	"	"	PUNCT
futech-391	320	8	identification	identification	NOUN
futech-391	320	9	of	of	ADP
futech-391	320	10	ulk1	ulk1	PROPN
futech-391	320	11	as	as	ADP
futech-391	320	12	a	a	DET
futech-391	320	13	novel	novel	ADJ
futech-391	320	14	mitophagyrelated	mitophagyrelate	VERB
futech-391	320	15	gene	gene	NOUN
futech-391	320	16	in	in	ADP
futech-391	320	17	diabetic	diabetic	ADJ
futech-391	320	18	nephropathy	nephropathy	NOUN
futech-391	320	19	,	,	PUNCT
futech-391	320	20	"	"	PUNCT
futech-391	320	21	frontiers	frontier	NOUN
futech-391	320	22	in	in	ADP
futech-391	320	23	endocrinology	endocrinology	NOUN
futech-391	320	24	,	,	PUNCT
futech-391	320	25	vol	vol	NOUN
futech-391	320	26	.	.	PROPN
futech-391	320	27	13	13	NUM
futech-391	320	28	,	,	PUNCT
futech-391	320	29	p.	p.	NOUN
futech-391	320	30	1079465	1079465	NUM
futech-391	320	31	,	,	PUNCT
futech-391	320	32	2023	2023	NUM
futech-391	320	33	.	.	PUNCT
futech-391	321	1	doi	doi	NOUN
futech-391	321	2	:	:	PUNCT
futech-391	321	3	10.3389	10.3389	NUM
futech-391	321	4	/	/	SYM
futech-391	321	5	fendo.2022.1079465	fendo.2022.1079465	NOUN
futech-391	321	6	.	.	PUNCT
futech-391	322	1	http://dx.doi.org/10.1177/1934578x251321758	http://dx.doi.org/10.1177/1934578x251321758	PROPN
futech-391	322	2	https://doi.org/10.1002/pmic.202400108	https://doi.org/10.1002/pmic.202400108	PROPN
futech-391	322	3	w.	w.	PROPN
futech-391	322	4	li	li	PROPN
futech-391	322	5	&	&	CCONJ
futech-391	322	6	sp	sp	PROPN
futech-391	322	7	.	.	PROPN
futech-391	322	8	chandran	chandran	PROPN
futech-391	322	9	/future	/future	PUNCT
futech-391	322	10	technology	technology	PROPN
futech-391	322	11	august	august	PROPN
futech-391	322	12	2025|	2025|	NUM
futech-391	322	13	volume	volume	NOUN
futech-391	322	14	04	04	NUM
futech-391	323	1	|	|	NOUN
futech-391	323	2	issue	issue	NOUN
futech-391	323	3	03	03	NUM
futech-391	324	1	|	|	ADV
futech-391	324	2	pages	page	NOUN
futech-391	324	3	193	193	NUM
futech-391	324	4	-	-	SYM
futech-391	324	5	203	203	NUM
futech-391	324	6	203	203	NUM
futech-391	324	7	[	[	SYM
futech-391	324	8	20	20	NUM
futech-391	324	9	]	]	PUNCT
futech-391	324	10	c.	c.	PROPN
futech-391	324	11	sabanayagam	sabanayagam	INTJ
futech-391	324	12	et	et	PROPN
futech-391	324	13	al	al	PROPN
futech-391	324	14	.	.	PROPN
futech-391	324	15	,	,	PUNCT
futech-391	324	16	"	"	PUNCT
futech-391	324	17	prediction	prediction	NOUN
futech-391	324	18	of	of	ADP
futech-391	324	19	diabetic	diabetic	ADJ
futech-391	324	20	kidney	kidney	NOUN
futech-391	324	21	disease	disease	NOUN
futech-391	324	22	risk	risk	NOUN
futech-391	324	23	using	use	VERB
futech-391	324	24	machine	machine	NOUN
futech-391	324	25	learning	learning	NOUN
futech-391	324	26	models	model	NOUN
futech-391	324	27	:	:	PUNCT
futech-391	324	28	a	a	DET
futech-391	324	29	population	population	NOUN
futech-391	324	30	-	-	PUNCT
futech-391	324	31	based	base	VERB
futech-391	324	32	cohort	cohort	NOUN
futech-391	324	33	study	study	NOUN
futech-391	324	34	of	of	ADP
futech-391	324	35	asian	asian	ADJ
futech-391	324	36	adults	adult	NOUN
futech-391	324	37	,	,	PUNCT
futech-391	324	38	"	"	PUNCT
futech-391	324	39	elife	elife	NOUN
futech-391	324	40	,	,	PUNCT
futech-391	324	41	vol	vol	NOUN
futech-391	324	42	.	.	PROPN
futech-391	324	43	12	12	NUM
futech-391	324	44	,	,	PUNCT
futech-391	324	45	p.	p.	NOUN
futech-391	324	46	e81878	e81878	ADJ
futech-391	324	47	,	,	PUNCT
futech-391	324	48	sep	sep	PROPN
futech-391	324	49	14	14	NUM
futech-391	324	50	2023	2023	NUM
futech-391	324	51	.	.	PUNCT
futech-391	325	1	doi	doi	NOUN
futech-391	325	2	:	:	PUNCT
futech-391	325	3	10.7554	10.7554	NUM
futech-391	325	4	/	/	SYM
futech-391	325	5	elife.81878	elife.81878	PROPN
futech-391	325	6	.	.	PUNCT
futech-391	326	1	[	[	X
futech-391	326	2	21	21	NUM
futech-391	326	3	]	]	X
futech-391	326	4	f.	f.	PROPN
futech-391	326	5	mesquita	mesquita	PROPN
futech-391	326	6	,	,	PUNCT
futech-391	326	7	j.	j.	PROPN
futech-391	326	8	bernardino	bernardino	PROPN
futech-391	326	9	,	,	PUNCT
futech-391	326	10	j.	j.	PROPN
futech-391	326	11	henriques	henriques	PROPN
futech-391	326	12	,	,	PUNCT
futech-391	326	13	j.	j.	PROPN
futech-391	326	14	f.	f.	PROPN
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futech-391	326	16	,	,	PUNCT
futech-391	326	17	r.	r.	PROPN
futech-391	326	18	t.	t.	PROPN
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futech-391	326	20	,	,	PUNCT
futech-391	326	21	and	and	CCONJ
futech-391	326	22	s.	s.	PROPN
futech-391	326	23	paredes	paredes	PROPN
futech-391	326	24	,	,	PUNCT
futech-391	326	25	"	"	PUNCT
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futech-391	326	27	learning	learn	VERB
futech-391	326	28	techniques	technique	NOUN
futech-391	326	29	to	to	PART
futech-391	326	30	predict	predict	VERB
futech-391	326	31	the	the	DET
futech-391	326	32	risk	risk	NOUN
futech-391	326	33	of	of	ADP
futech-391	326	34	developing	develop	VERB
futech-391	326	35	diabetic	diabetic	ADJ
futech-391	326	36	nephropathy	nephropathy	NOUN
futech-391	326	37	:	:	PUNCT
futech-391	326	38	a	a	DET
futech-391	326	39	literature	literature	NOUN
futech-391	326	40	review	review	NOUN
futech-391	326	41	,	,	PUNCT
futech-391	326	42	"	"	PUNCT
futech-391	326	43	j	j	PROPN
futech-391	326	44	diabetes	diabete	VERB
futech-391	326	45	metab	metab	NOUN
futech-391	326	46	disord	disord	NOUN
futech-391	326	47	,	,	PUNCT
futech-391	326	48	vol	vol	NOUN
futech-391	326	49	.	.	PROPN
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futech-391	326	51	,	,	PUNCT
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futech-391	326	54	1	1	NUM
futech-391	326	55	,	,	PUNCT
futech-391	326	56	pp	pp	ADJ
futech-391	326	57	.	.	PUNCT
futech-391	326	58	825	825	NUM
futech-391	326	59	-	-	SYM
futech-391	326	60	839	839	NUM
futech-391	326	61	,	,	PUNCT
futech-391	326	62	jun	jun	PROPN
futech-391	326	63	2024	2024	NUM
futech-391	326	64	.	.	PUNCT
futech-391	327	1	doi	doi	NOUN
futech-391	327	2	:	:	PUNCT
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futech-391	327	4	/	/	SYM
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futech-391	327	6	-	-	PUNCT
futech-391	327	7	023	023	NUM
futech-391	327	8	-	-	PUNCT
futech-391	327	9	01357	01357	NUM
futech-391	327	10	-	-	PUNCT
futech-391	327	11	4	4	NUM
futech-391	327	12	.	.	PUNCT
futech-391	328	1	[	[	X
futech-391	328	2	22	22	NUM
futech-391	328	3	]	]	PUNCT
futech-391	328	4	s.	s.	PROPN
futech-391	328	5	m.	m.	PROPN
futech-391	328	6	swaminathan	swaminathan	ADV
futech-391	328	7	et	et	PROPN
futech-391	328	8	al	al	PROPN
futech-391	328	9	.	.	PROPN
futech-391	328	10	,	,	PUNCT
futech-391	328	11	"	"	PUNCT
futech-391	328	12	novel	novel	ADJ
futech-391	328	13	biomarkers	biomarker	NOUN
futech-391	328	14	for	for	ADP
futech-391	328	15	prognosticating	prognosticate	VERB
futech-391	328	16	diabetic	diabetic	ADJ
futech-391	328	17	kidney	kidney	NOUN
futech-391	328	18	disease	disease	NOUN
futech-391	328	19	progression	progression	NOUN
futech-391	328	20	,	,	PUNCT
futech-391	328	21	"	"	PUNCT
futech-391	328	22	int	int	NOUN
futech-391	328	23	urol	urol	ADJ
futech-391	328	24	nephrol	nephrol	NOUN
futech-391	328	25	,	,	PUNCT
futech-391	328	26	vol	vol	NOUN
futech-391	328	27	.	.	PROPN
futech-391	329	1	55	55	NUM
futech-391	329	2	,	,	PUNCT
futech-391	329	3	no	no	INTJ
futech-391	329	4	.	.	NOUN
futech-391	329	5	4	4	NUM
futech-391	329	6	,	,	PUNCT
futech-391	329	7	pp	pp	ADJ
futech-391	329	8	.	.	PUNCT
futech-391	330	1	913	913	NUM
futech-391	330	2	-	-	SYM
futech-391	330	3	928	928	NUM
futech-391	330	4	,	,	PUNCT
futech-391	330	5	apr	apr	NOUN
futech-391	330	6	2023	2023	NUM
futech-391	330	7	.	.	PUNCT
futech-391	331	1	doi	doi	NOUN
futech-391	331	2	:	:	PUNCT
futech-391	331	3	10.1007	10.1007	NUM
futech-391	331	4	/	/	SYM
futech-391	331	5	s11255	s11255	NOUN
futech-391	331	6	-	-	PUNCT
futech-391	331	7	022	022	NUM
futech-391	331	8	-	-	PUNCT
futech-391	331	9	03354	03354	NUM
futech-391	331	10	-	-	SYM
futech-391	331	11	7	7	NUM
futech-391	331	12	.	.	PUNCT
futech-391	332	1	[	[	X
futech-391	332	2	23	23	NUM
futech-391	332	3	]	]	X
futech-391	332	4	c.	c.	PROPN
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futech-391	332	6	et	et	PROPN
futech-391	332	7	al	al	PROPN
futech-391	332	8	.	.	PROPN
futech-391	332	9	,	,	PUNCT
futech-391	332	10	"	"	PUNCT
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futech-391	332	13	in	in	ADP
futech-391	332	14	the	the	DET
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futech-391	332	16	of	of	ADP
futech-391	332	17	early	early	ADJ
futech-391	332	18	diabetic	diabetic	ADJ
futech-391	332	19	nephropathy	nephropathy	NOUN
futech-391	332	20	,	,	PUNCT
futech-391	332	21	"	"	PUNCT
futech-391	332	22	j	j	PROPN
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futech-391	332	24	res	re	NOUN
futech-391	332	25	,	,	PUNCT
futech-391	332	26	vol	vol	NOUN
futech-391	332	27	.	.	PROPN
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futech-391	332	29	,	,	PUNCT
futech-391	332	30	no	no	INTJ
futech-391	332	31	.	.	NOUN
futech-391	332	32	1	1	NUM
futech-391	332	33	,	,	PUNCT
futech-391	332	34	p.	p.	NOUN
futech-391	332	35	4626125	4626125	NUM
futech-391	332	36	,	,	PUNCT
futech-391	332	37	2016	2016	NUM
futech-391	332	38	.	.	PUNCT
futech-391	333	1	doi	doi	NOUN
futech-391	333	2	:	:	PUNCT
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futech-391	333	4	.	.	PUNCT
futech-391	334	1	[	[	X
futech-391	334	2	24	24	NUM
futech-391	334	3	]	]	PUNCT
futech-391	334	4	m.	m.	NOUN
futech-391	334	5	colombo	colombo	PROPN
futech-391	334	6	et	et	PROPN
futech-391	334	7	al	al	PROPN
futech-391	334	8	.	.	PROPN
futech-391	334	9	,	,	PUNCT
futech-391	334	10	"	"	PUNCT
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futech-391	334	12	kidney	kidney	NOUN
futech-391	334	13	injury	injury	NOUN
futech-391	334	14	molecule	molecule	NOUN
futech-391	334	15	1	1	NUM
futech-391	334	16	and	and	CCONJ
futech-391	334	17	β	β	PROPN
futech-391	334	18	2	2	NUM
futech-391	334	19	-	-	PUNCT
futech-391	334	20	microglobulin	microglobulin	PROPN
futech-391	334	21	perform	perform	NOUN
futech-391	334	22	as	as	ADV
futech-391	334	23	well	well	ADV
futech-391	334	24	as	as	ADP
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futech-391	334	27	panels	panel	NOUN
futech-391	334	28	for	for	ADP
futech-391	334	29	prediction	prediction	NOUN
futech-391	334	30	of	of	ADP
futech-391	334	31	rapid	rapid	ADJ
futech-391	334	32	decline	decline	NOUN
futech-391	334	33	in	in	ADP
futech-391	334	34	renal	renal	ADJ
futech-391	334	35	function	function	NOUN
futech-391	334	36	in	in	ADP
futech-391	334	37	type	type	NOUN
futech-391	334	38	2	2	NUM
futech-391	334	39	diabetes	diabete	NOUN
futech-391	334	40	,	,	PUNCT
futech-391	334	41	"	"	PUNCT
futech-391	334	42	diabetologia	diabetologia	NOUN
futech-391	334	43	,	,	PUNCT
futech-391	334	44	vol	vol	NOUN
futech-391	334	45	.	.	PROPN
futech-391	334	46	62	62	NUM
futech-391	334	47	,	,	PUNCT
futech-391	334	48	pp	pp	ADJ
futech-391	334	49	.	.	PUNCT
futech-391	335	1	156	156	NUM
futech-391	335	2	-	-	SYM
futech-391	335	3	168	168	NUM
futech-391	335	4	,	,	PUNCT
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futech-391	335	6	.	.	PUNCT
futech-391	336	1	doi	doi	NOUN
futech-391	336	2	:	:	PUNCT
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futech-391	336	4	/	/	SYM
futech-391	336	5	s00125	s00125	NUM
futech-391	336	6	-	-	PUNCT
futech-391	336	7	018	018	NUM
futech-391	336	8	-	-	PUNCT
futech-391	336	9	4741	4741	NUM
futech-391	336	10	-	-	SYM
futech-391	336	11	9	9	NUM
futech-391	336	12	.	.	PUNCT
futech-391	337	1	[	[	X
futech-391	337	2	25	25	NUM
futech-391	337	3	]	]	PUNCT
futech-391	337	4	a.	a.	NOUN
futech-391	337	5	alkhalaf	alkhalaf	PROPN
futech-391	337	6	et	et	PROPN
futech-391	337	7	al	al	PROPN
futech-391	337	8	.	.	PROPN
futech-391	337	9	,	,	PUNCT
futech-391	337	10	"	"	PUNCT
futech-391	337	11	multicentric	multicentric	ADJ
futech-391	337	12	validation	validation	NOUN
futech-391	337	13	of	of	ADP
futech-391	337	14	proteomic	proteomic	ADJ
futech-391	337	15	biomarkers	biomarker	NOUN
futech-391	337	16	in	in	ADP
futech-391	337	17	urine	urine	NOUN
futech-391	337	18	specific	specific	ADJ
futech-391	337	19	for	for	ADP
futech-391	337	20	diabetic	diabetic	ADJ
futech-391	337	21	nephropathy	nephropathy	NOUN
futech-391	337	22	,	,	PUNCT
futech-391	337	23	"	"	PUNCT
futech-391	337	24	plos	plos	PROPN
futech-391	337	25	one	one	NUM
futech-391	337	26	,	,	PUNCT
futech-391	337	27	vol	vol	NOUN
futech-391	337	28	.	.	PROPN
futech-391	337	29	5	5	NUM
futech-391	337	30	,	,	PUNCT
futech-391	337	31	no	no	INTJ
futech-391	337	32	.	.	NOUN
futech-391	337	33	10	10	NUM
futech-391	337	34	,	,	PUNCT
futech-391	337	35	p.	p.	NOUN
futech-391	337	36	e13421	e13421	PROPN
futech-391	337	37	,	,	PUNCT
futech-391	337	38	oct	oct	PROPN
futech-391	337	39	20	20	NUM
futech-391	337	40	2010	2010	NUM
futech-391	337	41	.	.	PUNCT
futech-391	338	1	doi	doi	NOUN
futech-391	338	2	:	:	PUNCT
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futech-391	338	4	/	/	SYM
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futech-391	338	6	.	.	PUNCT
futech-391	339	1	[	[	X
futech-391	339	2	26	26	NUM
futech-391	339	3	]	]	PUNCT
futech-391	339	4	m.	m.	NOUN
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futech-391	339	9	,	,	PUNCT
futech-391	339	10	"	"	PUNCT
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futech-391	339	12	proteomics	proteomic	NOUN
futech-391	339	13	predict	predict	VERB
futech-391	339	14	onset	onset	NOUN
futech-391	339	15	of	of	ADP
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futech-391	339	19	type	type	NOUN
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futech-391	339	24	a	a	DET
futech-391	339	25	sub	sub	NOUN
futech-391	339	26	-	-	NOUN
futech-391	339	27	study	study	NOUN
futech-391	339	28	of	of	ADP
futech-391	339	29	the	the	DET
futech-391	339	30	direct	direct	ADJ
futech-391	339	31	-	-	PUNCT
futech-391	339	32	protect	protect	NOUN
futech-391	339	33	2	2	NUM
futech-391	339	34	study	study	NOUN
futech-391	339	35	,	,	PUNCT
futech-391	339	36	"	"	PUNCT
futech-391	339	37	nephrol	nephrol	ADJ
futech-391	339	38	dial	dial	NOUN
futech-391	339	39	transplant	transplant	NOUN
futech-391	339	40	,	,	PUNCT
futech-391	339	41	vol	vol	NOUN
futech-391	339	42	.	.	PROPN
futech-391	339	43	32	32	NUM
futech-391	339	44	,	,	PUNCT
futech-391	339	45	no	no	INTJ
futech-391	339	46	.	.	NOUN
futech-391	339	47	11	11	NUM
futech-391	339	48	,	,	PUNCT
futech-391	339	49	pp	pp	ADJ
futech-391	339	50	.	.	PUNCT
futech-391	339	51	1866	1866	NUM
futech-391	339	52	-	-	SYM
futech-391	339	53	1873	1873	NUM
futech-391	339	54	,	,	PUNCT
futech-391	339	55	nov	nov	PROPN
futech-391	339	56	1	1	NUM
futech-391	339	57	2017	2017	NUM
futech-391	339	58	.	.	PUNCT
futech-391	340	1	doi	doi	NOUN
futech-391	340	2	:	:	PUNCT
futech-391	340	3	10.1093	10.1093	NUM
futech-391	340	4	/	/	SYM
futech-391	340	5	ndt	ndt	PROPN
futech-391	340	6	/	/	SYM
futech-391	340	7	gfw292	gfw292	PROPN
futech-391	340	8	.	.	PUNCT
futech-391	341	1	[	[	X
futech-391	341	2	27	27	NUM
futech-391	341	3	]	]	PUNCT
futech-391	341	4	m.	m.	NOUN
futech-391	341	5	kammer	kammer	PROPN
futech-391	341	6	et	et	PROPN
futech-391	341	7	al	al	PROPN
futech-391	341	8	.	.	PROPN
futech-391	341	9	,	,	PUNCT
futech-391	341	10	"	"	PUNCT
futech-391	341	11	integrative	integrative	ADJ
futech-391	341	12	analysis	analysis	NOUN
futech-391	341	13	of	of	ADP
futech-391	341	14	prognostic	prognostic	ADJ
futech-391	341	15	biomarkers	biomarker	NOUN
futech-391	341	16	derived	derive	VERB
futech-391	341	17	from	from	ADP
futech-391	341	18	multiomics	multiomics	NOUN
futech-391	341	19	panels	panel	NOUN
futech-391	341	20	helps	help	VERB
futech-391	341	21	discrimination	discrimination	NOUN
futech-391	341	22	of	of	ADP
futech-391	341	23	chronic	chronic	ADJ
futech-391	341	24	kidney	kidney	NOUN
futech-391	341	25	disease	disease	NOUN
futech-391	341	26	trajectories	trajectorie	VERB
futech-391	341	27	in	in	ADP
futech-391	341	28	people	people	NOUN
futech-391	341	29	with	with	ADP
futech-391	341	30	type	type	NOUN
futech-391	341	31	2	2	NUM
futech-391	341	32	diabetes	diabete	NOUN
futech-391	341	33	,	,	PUNCT
futech-391	341	34	"	"	PUNCT
futech-391	341	35	kidney	kidney	NOUN
futech-391	341	36	int	int	NOUN
futech-391	341	37	,	,	PUNCT
futech-391	341	38	vol	vol	NOUN
futech-391	341	39	.	.	PROPN
futech-391	342	1	96	96	NUM
futech-391	342	2	,	,	PUNCT
futech-391	342	3	no	no	INTJ
futech-391	342	4	.	.	NOUN
futech-391	342	5	6	6	NUM
futech-391	342	6	,	,	PUNCT
futech-391	342	7	pp	pp	ADJ
futech-391	342	8	.	.	PUNCT
futech-391	343	1	1381	1381	NUM
futech-391	343	2	-	-	SYM
futech-391	343	3	1388	1388	NUM
futech-391	343	4	,	,	PUNCT
futech-391	343	5	dec	dec	PROPN
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futech-391	343	7	.	.	PUNCT
futech-391	344	1	doi	doi	NOUN
futech-391	344	2	:	:	PUNCT
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futech-391	344	4	/	/	SYM
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futech-391	344	6	.	.	PUNCT
futech-391	345	1	[	[	X
futech-391	345	2	28	28	NUM
futech-391	345	3	]	]	X
futech-391	345	4	e.	e.	PROPN
futech-391	345	5	soltani	soltani	PROPN
futech-391	345	6	-	-	PROPN
futech-391	345	7	fard	fard	PROPN
futech-391	345	8	et	et	PROPN
futech-391	345	9	al	al	PROPN
futech-391	345	10	.	.	PROPN
futech-391	345	11	,	,	PUNCT
futech-391	345	12	"	"	PUNCT
futech-391	345	13	urinary	urinary	ADJ
futech-391	345	14	biomarkers	biomarker	NOUN
futech-391	345	15	in	in	ADP
futech-391	345	16	diabetic	diabetic	ADJ
futech-391	345	17	nephropathy	nephropathy	NOUN
futech-391	345	18	,	,	PUNCT
futech-391	345	19	"	"	PUNCT
futech-391	345	20	clin	clin	PROPN
futech-391	345	21	chim	chim	PROPN
futech-391	345	22	acta	acta	PROPN
futech-391	345	23	,	,	PUNCT
futech-391	345	24	vol	vol	NOUN
futech-391	345	25	.	.	PROPN
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futech-391	346	2	,	,	PUNCT
futech-391	346	3	p.	p.	NOUN
futech-391	346	4	119762	119762	NUM
futech-391	346	5	,	,	PUNCT
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futech-391	346	7	15	15	NUM
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futech-391	346	9	.	.	PUNCT
futech-391	347	1	doi	doi	NOUN
futech-391	347	2	:	:	PUNCT
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futech-391	348	1	[	[	X
futech-391	348	2	29	29	NUM
futech-391	348	3	]	]	PUNCT
futech-391	348	4	j.	j.	PROPN
futech-391	348	5	g.	g.	PROPN
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futech-391	348	7	et	et	PROPN
futech-391	348	8	al	al	PROPN
futech-391	348	9	.	.	PROPN
futech-391	348	10	,	,	PUNCT
futech-391	348	11	"	"	PUNCT
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futech-391	348	14	kidney	kidney	NOUN
futech-391	348	15	tubule	tubule	NOUN
futech-391	348	16	disease	disease	NOUN
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futech-391	348	18	risk	risk	NOUN
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futech-391	348	20	end	end	NOUN
futech-391	348	21	-	-	PUNCT
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futech-391	348	23	kidney	kidney	NOUN
futech-391	348	24	disease	disease	NOUN
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futech-391	348	32	"	"	PUNCT
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futech-391	348	36	,	,	PUNCT
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futech-391	348	40	,	,	PUNCT
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futech-391	348	42	.	.	NOUN
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futech-391	348	44	,	,	PUNCT
futech-391	348	45	pp	pp	ADJ
futech-391	348	46	.	.	PUNCT
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futech-391	348	48	-	-	SYM
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futech-391	348	50	,	,	PUNCT
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futech-391	349	1	doi	doi	NOUN
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futech-391	350	3	]	]	X
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futech-391	350	9	.	.	PROPN
futech-391	350	10	,	,	PUNCT
futech-391	350	11	"	"	PUNCT
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futech-391	350	13	-	-	PUNCT
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futech-391	350	15	of	of	ADP
futech-391	350	16	mthfr	mthfr	PROPN
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futech-391	350	18	t	t	PROPN
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futech-391	350	21	type	type	NOUN
futech-391	350	22	2	2	NUM
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futech-391	350	24	mellitus	mellitus	NOUN
futech-391	350	25	in	in	ADP
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futech-391	350	27	region	region	PROPN
futech-391	350	28	,	,	PUNCT
futech-391	350	29	"	"	PUNCT
futech-391	350	30	diabetes	diabete	VERB
futech-391	350	31	metab	metab	NOUN
futech-391	350	32	syndr	syndr	NOUN
futech-391	350	33	,	,	PUNCT
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futech-391	350	35	.	.	PROPN
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futech-391	350	37	,	,	PUNCT
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futech-391	350	39	.	.	NOUN
futech-391	350	40	2	2	NUM
futech-391	350	41	,	,	PUNCT
futech-391	350	42	p.	p.	NOUN
futech-391	350	43	102965	102965	NUM
futech-391	350	44	,	,	PUNCT
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futech-391	350	47	.	.	PUNCT
futech-391	351	1	doi	doi	NOUN
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futech-391	351	6	.	.	PUNCT
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futech-391	352	3	]	]	PUNCT
futech-391	352	4	t.	t.	PROPN
futech-391	352	5	sen	sen	PROPN
futech-391	352	6	et	et	PROPN
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futech-391	352	8	.	.	PROPN
futech-391	352	9	,	,	PUNCT
futech-391	352	10	"	"	PUNCT
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futech-391	352	12	of	of	ADP
futech-391	352	13	action	action	NOUN
futech-391	352	14	of	of	ADP
futech-391	352	15	the	the	DET
futech-391	352	16	sodiumglucose	sodiumglucose	NOUN
futech-391	352	17	cotransporter-2	cotransporter-2	NUM
futech-391	352	18	(	(	PUNCT
futech-391	352	19	sglt2	sglt2	NOUN
futech-391	352	20	)	)	PUNCT
futech-391	352	21	inhibitor	inhibitor	NOUN
futech-391	352	22	canagliflozin	canagliflozin	NOUN
futech-391	352	23	on	on	ADP
futech-391	352	24	tubular	tubular	ADJ
futech-391	352	25	inflammation	inflammation	NOUN
futech-391	352	26	and	and	CCONJ
futech-391	352	27	damage	damage	NOUN
futech-391	352	28	:	:	PUNCT
futech-391	352	29	a	a	DET
futech-391	352	30	post	post	X
futech-391	352	31	hoc	hoc	X
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futech-391	352	33	analysis	analysis	NOUN
futech-391	352	34	of	of	ADP
futech-391	352	35	the	the	DET
futech-391	352	36	canvas	canvas	NOUN
futech-391	352	37	trial	trial	NOUN
futech-391	352	38	,	,	PUNCT
futech-391	352	39	"	"	PUNCT
futech-391	352	40	diabetes	diabetes	NOUN
futech-391	352	41	obes	obes	PRON
futech-391	352	42	metab	metab	NOUN
futech-391	352	43	,	,	PUNCT
futech-391	352	44	vol	vol	NOUN
futech-391	352	45	.	.	PROPN
futech-391	352	46	24	24	NUM
futech-391	352	47	,	,	PUNCT
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futech-391	352	49	.	.	NOUN
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futech-391	352	51	,	,	PUNCT
futech-391	352	52	pp	pp	ADJ
futech-391	352	53	.	.	PUNCT
futech-391	353	1	1950	1950	NUM
futech-391	353	2	-	-	SYM
futech-391	353	3	1956	1956	NUM
futech-391	353	4	,	,	PUNCT
futech-391	353	5	oct	oct	NOUN
futech-391	353	6	2022	2022	NUM
futech-391	353	7	.	.	PUNCT
futech-391	354	1	doi	doi	NOUN
futech-391	354	2	:	:	PUNCT
futech-391	354	3	10.1111	10.1111	NUM
futech-391	354	4	/	/	SYM
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futech-391	354	6	.	.	PUNCT
futech-391	355	1	[	[	X
futech-391	355	2	32	32	NUM
futech-391	355	3	]	]	PUNCT
futech-391	355	4	d.	d.	PROPN
futech-391	355	5	j.	j.	PROPN
futech-391	355	6	wexler	wexler	PROPN
futech-391	355	7	et	et	PROPN
futech-391	355	8	al	al	PROPN
futech-391	355	9	.	.	PROPN
futech-391	355	10	,	,	PUNCT
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futech-391	355	17	on	on	ADP
futech-391	355	18	kidney	kidney	NOUN
futech-391	355	19	outcomes	outcome	NOUN
futech-391	355	20	in	in	ADP
futech-391	355	21	type	type	NOUN
futech-391	355	22	2	2	NUM
futech-391	355	23	diabetes	diabete	NOUN
futech-391	355	24	:	:	PUNCT
futech-391	355	25	the	the	DET
futech-391	355	26	grade	grade	NOUN
futech-391	355	27	randomized	randomize	VERB
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futech-391	355	29	trial	trial	NOUN
futech-391	355	30	,	,	PUNCT
futech-391	355	31	"	"	PUNCT
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futech-391	355	35	,	,	PUNCT
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futech-391	355	41	.	.	NOUN
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futech-391	355	43	,	,	PUNCT
futech-391	355	44	pp	pp	ADJ
futech-391	355	45	.	.	PUNCT
futech-391	356	1	705	705	NUM
futech-391	356	2	-	-	SYM
futech-391	356	3	714	714	NUM
futech-391	356	4	,	,	PUNCT
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futech-391	356	6	1	1	NUM
futech-391	356	7	2023	2023	NUM
futech-391	356	8	.	.	PUNCT
futech-391	357	1	doi	doi	NOUN
futech-391	357	2	:	:	PUNCT
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futech-391	357	6	.	.	PUNCT
futech-391	358	1	[	[	X
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futech-391	358	3	]	]	PUNCT
futech-391	358	4	p.	p.	NOUN
futech-391	358	5	bjornstad	bjornstad	PROPN
futech-391	358	6	et	et	PROPN
futech-391	358	7	al	al	PROPN
futech-391	358	8	.	.	PROPN
futech-391	358	9	,	,	PUNCT
futech-391	358	10	"	"	PUNCT
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futech-391	358	13	,	,	PUNCT
futech-391	358	14	sensitivity	sensitivity	NOUN
futech-391	358	15	,	,	PUNCT
futech-391	358	16	and	and	CCONJ
futech-391	358	17	kidney	kidney	NOUN
futech-391	358	18	function	function	NOUN
futech-391	358	19	in	in	ADP
futech-391	358	20	young	young	ADJ
futech-391	358	21	individuals	individual	NOUN
futech-391	358	22	with	with	ADP
futech-391	358	23	type	type	NOUN
futech-391	358	24	2	2	NUM
futech-391	358	25	diabetes	diabete	NOUN
futech-391	358	26	,	,	PUNCT
futech-391	358	27	"	"	PUNCT
futech-391	358	28	diabetes	diabetes	NOUN
futech-391	358	29	care	care	NOUN
futech-391	358	30	,	,	PUNCT
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futech-391	359	8	.	.	PUNCT
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futech-391	360	2	-	-	SYM
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futech-391	360	4	,	,	PUNCT
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futech-391	360	6	1	1	NUM
futech-391	360	7	2024	2024	NUM
futech-391	360	8	.	.	PUNCT
futech-391	361	1	doi	doi	NOUN
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futech-391	361	8	.	.	PUNCT
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futech-391	362	3	]	]	PUNCT
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futech-391	362	41	.	.	PUNCT
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futech-391	363	2	-	-	SYM
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futech-391	363	8	.	.	PUNCT
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futech-391	364	8	-	-	PUNCT
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futech-391	366	4	,	,	PUNCT
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futech-391	366	7	.	.	PUNCT
futech-391	367	1	doi	doi	NOUN
futech-391	367	2	:	:	PUNCT
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futech-391	368	39	1	1	NUM
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futech-391	368	41	pp	pp	ADJ
futech-391	368	42	.	.	PUNCT
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futech-391	369	2	-	-	SYM
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futech-391	369	4	,	,	PUNCT
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futech-391	369	7	.	.	PUNCT
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futech-391	370	2	:	:	PUNCT
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futech-391	371	16	adverse	adverse	ADJ
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futech-391	371	18	in	in	ADP
futech-391	371	19	type	type	NOUN
futech-391	371	20	2	2	NUM
futech-391	371	21	diabetes	diabetes	NOUN
futech-391	371	22	and	and	CCONJ
futech-391	371	23	ckd	ckd	PROPN
futech-391	371	24	:	:	PUNCT
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futech-391	371	45	,	,	PUNCT
futech-391	371	46	pp	pp	ADJ
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futech-391	372	2	-	-	SYM
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futech-391	373	2	:	:	PUNCT
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futech-391	374	21	in	in	ADP
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futech-391	374	25	2	2	NUM
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futech-391	374	27	and	and	CCONJ
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futech-391	374	31	:	:	PUNCT
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futech-391	374	47	,	,	PUNCT
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futech-391	375	2	-	-	SYM
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futech-391	375	4	,	,	PUNCT
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futech-391	375	7	.	.	PUNCT
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futech-391	376	8	-	-	PUNCT
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futech-391	377	3	]	]	PUNCT
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futech-391	377	43	,	,	PUNCT
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futech-391	377	45	.	.	PUNCT
futech-391	378	1	doi	doi	NOUN
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futech-391	380	6	:	:	PUNCT
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futech-391	382	1	doi	doi	NOUN
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futech-391	382	4	/	/	SYM
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futech-391	383	1	this	this	DET
futech-391	383	2	article	article	NOUN
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futech-391	383	4	an	an	DET
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futech-391	383	6	-	-	PUNCT
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futech-391	383	20	(	(	PUNCT
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futech-391	383	23	)	)	PUNCT
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futech-391	384	1	https://doi.org/10.1007/s00125-018-4741-9	https://doi.org/10.1007/s00125-018-4741-9	NUM
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