id	sid	tid	token	lemma	pos
gsrj-12	1	1	refractory	refractory	NOUN
gsrj-12	1	2	epilepsy	epilepsy	NOUN
gsrj-12	1	3	:	:	PUNCT
gsrj-12	1	4	mechanisms	mechanism	NOUN
gsrj-12	1	5	of	of	ADP
gsrj-12	1	6	pharmacoresistance	pharmacoresistance	PROPN
gsrj-12	1	7	ariel	ariel	PROPN
gsrj-12	1	8	le	le	PROPN
gsrj-12	1	9	,	,	PUNCT
gsrj-12	1	10	makenzie	makenzie	PROPN
gsrj-12	1	11	thomas	thomas	PROPN
gsrj-12	1	12	,	,	PUNCT
gsrj-12	1	13	brady	brady	PROPN
gsrj-12	1	14	stallman	stallman	PROPN
gsrj-12	1	15	,	,	PUNCT
gsrj-12	1	16	kathryn	kathryn	PROPN
gsrj-12	1	17	meadows	meadow	NOUN
gsrj-12	1	18	,	,	PUNCT
gsrj-12	1	19	vidya	vidya	PROPN
gsrj-12	1	20	bhargava	bhargava	PROPN
gsrj-12	1	21	volume	volume	PROPN
gsrj-12	1	22	one	one	NUM
gsrj-12	1	23	edition	edition	NOUN
gsrj-12	1	24	one	one	NUM
gsrj-12	1	25	february	february	PROPN
gsrj-12	1	26	2021	2021	NUM
gsrj-12	1	27	georgetown	georgetown	PROPN
gsrj-12	1	28	scientific	scientific	PROPN
gsrj-12	1	29	research	research	PROPN
gsrj-12	1	30	journal	journal	PROPN
gsrj-12	1	31	99	99	NUM
gsrj-12	1	32	georgetown	georgetown	PROPN
gsrj-12	1	33	scientific	scientific	PROPN
gsrj-12	1	34	research	research	PROPN
gsrj-12	1	35	journal	journal	PROPN
gsrj-12	1	36	https://doi.org/10.48091/uwyg8998	https://doi.org/10.48091/uwyg8998	PROPN
gsrj-12	1	37	refractory	refractory	PROPN
gsrj-12	1	38	epilepsy	epilepsy	NOUN
gsrj-12	1	39	:	:	PUNCT
gsrj-12	1	40	mechanisms	mechanism	NOUN
gsrj-12	1	41	of	of	ADP
gsrj-12	1	42	pharmacoresistance	pharmacoresistance	PROPN
gsrj-12	1	43	ariel	ariel	PROPN
gsrj-12	1	44	le	le	PROPN
gsrj-12	1	45	,	,	PUNCT
gsrj-12	1	46	makenzie	makenzie	PROPN
gsrj-12	1	47	thomas	thomas	PROPN
gsrj-12	1	48	,	,	PUNCT
gsrj-12	1	49	brady	brady	PROPN
gsrj-12	1	50	stallman	stallman	PROPN
gsrj-12	1	51	,	,	PUNCT
gsrj-12	1	52	kathryn	kathryn	PROPN
gsrj-12	1	53	meadows	meadow	NOUN
gsrj-12	1	54	,	,	PUNCT
gsrj-12	1	55	and	and	CCONJ
gsrj-12	1	56	vidya	vidya	PROPN
gsrj-12	1	57	bhargava	bhargava	PROPN
gsrj-12	1	58	department	department	PROPN
gsrj-12	1	59	of	of	ADP
gsrj-12	1	60	human	human	PROPN
gsrj-12	1	61	science	science	PROPN
gsrj-12	1	62	,	,	PUNCT
gsrj-12	1	63	georgetown	georgetown	PROPN
gsrj-12	1	64	university	university	PROPN
gsrj-12	1	65	school	school	NOUN
gsrj-12	1	66	of	of	ADP
gsrj-12	1	67	nursing	nursing	NOUN
gsrj-12	1	68	and	and	CCONJ
gsrj-12	1	69	health	health	NOUN
gsrj-12	1	70	studies	study	NOUN
gsrj-12	1	71	,	,	PUNCT
gsrj-12	1	72	washington	washington	PROPN
gsrj-12	1	73	d.c	d.c	PROPN
gsrj-12	1	74	.	.	PROPN
gsrj-12	1	75	,	,	PUNCT
gsrj-12	1	76	united	united	PROPN
gsrj-12	1	77	states	states	PROPN
gsrj-12	1	78	of	of	ADP
gsrj-12	1	79	america	america	PROPN
gsrj-12	1	80	e	e	PROPN
gsrj-12	1	81	-	-	NOUN
gsrj-12	1	82	mail	mail	NOUN
gsrj-12	1	83	:	:	PUNCT
gsrj-12	1	84	aql3@georgetown.edu	aql3@georgetown.edu	PROPN
gsrj-12	1	85	,	,	PUNCT
gsrj-12	1	86	mst82@georgetown.edu	mst82@georgetown.edu	PROPN
gsrj-12	1	87	,	,	PUNCT
gsrj-12	1	88	bes104@georgetown.edu	bes104@georgetown.edu	PROPN
gsrj-12	1	89	,	,	PUNCT
gsrj-12	1	90	kgm65@georgetown.edu	kgm65@georgetown.edu	PROPN
gsrj-12	1	91	,	,	PUNCT
gsrj-12	1	92	vdb29@georgetown.edu	vdb29@georgetown.edu	NUM
gsrj-12	1	93	abstract	abstract	ADJ
gsrj-12	1	94	refractory	refractory	NOUN
gsrj-12	1	95	or	or	CCONJ
gsrj-12	1	96	drug	drug	NOUN
gsrj-12	1	97	-	-	PUNCT
gsrj-12	1	98	resistant	resistant	ADJ
gsrj-12	1	99	epilepsy	epilepsy	NOUN
gsrj-12	1	100	is	be	AUX
gsrj-12	1	101	a	a	DET
gsrj-12	1	102	complex	complex	ADJ
gsrj-12	1	103	and	and	CCONJ
gsrj-12	1	104	debilitating	debilitating	ADJ
gsrj-12	1	105	disorder	disorder	NOUN
gsrj-12	1	106	that	that	SCONJ
gsrj-12	1	107	impacts	impact	VERB
gsrj-12	1	108	over	over	ADP
gsrj-12	1	109	onethird	onethird	PROPN
gsrj-12	1	110	of	of	ADP
gsrj-12	1	111	people	people	NOUN
gsrj-12	1	112	diagnosed	diagnose	VERB
gsrj-12	1	113	with	with	ADP
gsrj-12	1	114	epilepsy	epilepsy	NOUN
gsrj-12	1	115	.	.	PUNCT
gsrj-12	2	1	many	many	ADJ
gsrj-12	2	2	studies	study	NOUN
gsrj-12	2	3	have	have	AUX
gsrj-12	2	4	suggested	suggest	VERB
gsrj-12	2	5	a	a	DET
gsrj-12	2	6	variety	variety	NOUN
gsrj-12	2	7	of	of	ADP
gsrj-12	2	8	possible	possible	ADJ
gsrj-12	2	9	hypotheses	hypothesis	NOUN
gsrj-12	2	10	for	for	ADP
gsrj-12	2	11	drug	drug	NOUN
gsrj-12	2	12	-	-	PUNCT
gsrj-12	2	13	resistant	resistant	ADJ
gsrj-12	2	14	epilepsy	epilepsy	NOUN
gsrj-12	2	15	,	,	PUNCT
gsrj-12	2	16	including	include	VERB
gsrj-12	2	17	the	the	DET
gsrj-12	2	18	degeneration	degeneration	NOUN
gsrj-12	2	19	of	of	ADP
gsrj-12	2	20	neural	neural	ADJ
gsrj-12	2	21	networks	network	NOUN
gsrj-12	2	22	,	,	PUNCT
gsrj-12	2	23	alterations	alteration	NOUN
gsrj-12	2	24	of	of	ADP
gsrj-12	2	25	anti	anti	ADJ
gsrj-12	2	26	-	-	ADJ
gsrj-12	2	27	epileptic	epileptic	ADJ
gsrj-12	2	28	drug	drug	NOUN
gsrj-12	2	29	(	(	PUNCT
gsrj-12	2	30	aed	aed	NOUN
gsrj-12	2	31	)	)	PUNCT
gsrj-12	2	32	targets	target	NOUN
gsrj-12	2	33	,	,	PUNCT
gsrj-12	2	34	intrinsic	intrinsic	ADJ
gsrj-12	2	35	severity	severity	NOUN
gsrj-12	2	36	/	/	SYM
gsrj-12	2	37	frequency	frequency	NOUN
gsrj-12	2	38	of	of	ADP
gsrj-12	2	39	seizures	seizure	NOUN
gsrj-12	2	40	,	,	PUNCT
gsrj-12	2	41	and	and	CCONJ
gsrj-12	2	42	genetic	genetic	ADJ
gsrj-12	2	43	predisposition	predisposition	NOUN
gsrj-12	2	44	to	to	PART
gsrj-12	2	45	pharmacoresistance	pharmacoresistance	PROPN
gsrj-12	2	46	.	.	PUNCT
gsrj-12	3	1	however	however	ADV
gsrj-12	3	2	,	,	PUNCT
gsrj-12	3	3	extensive	extensive	ADJ
gsrj-12	3	4	research	research	NOUN
gsrj-12	3	5	suggests	suggest	VERB
gsrj-12	3	6	that	that	SCONJ
gsrj-12	3	7	the	the	DET
gsrj-12	3	8	overexpression	overexpression	NOUN
gsrj-12	3	9	of	of	ADP
gsrj-12	3	10	efflux	efflux	NOUN
gsrj-12	3	11	protein	protein	NOUN
gsrj-12	3	12	transporters	transporter	NOUN
gsrj-12	3	13	in	in	ADP
gsrj-12	3	14	brain	brain	NOUN
gsrj-12	3	15	tissue	tissue	NOUN
gsrj-12	3	16	is	be	AUX
gsrj-12	3	17	the	the	DET
gsrj-12	3	18	most	most	ADV
gsrj-12	3	19	viable	viable	ADJ
gsrj-12	3	20	hypothesis	hypothesis	NOUN
gsrj-12	3	21	.	.	PUNCT
gsrj-12	4	1	specifically	specifically	ADV
gsrj-12	4	2	,	,	PUNCT
gsrj-12	4	3	the	the	DET
gsrj-12	4	4	overexpression	overexpression	NOUN
gsrj-12	4	5	of	of	ADP
gsrj-12	4	6	p	p	NOUN
gsrj-12	4	7	-	-	PUNCT
gsrj-12	4	8	glycoproteins	glycoprotein	NOUN
gsrj-12	4	9	(	(	PUNCT
gsrj-12	4	10	p	p	NOUN
gsrj-12	4	11	-	-	PUNCT
gsrj-12	4	12	gps	gps	NOUN
gsrj-12	4	13	)	)	PUNCT
gsrj-12	4	14	at	at	ADP
gsrj-12	4	15	the	the	DET
gsrj-12	4	16	blood	blood	NOUN
gsrj-12	4	17	brain	brain	NOUN
gsrj-12	4	18	barrier	barrier	NOUN
gsrj-12	4	19	proves	prove	VERB
gsrj-12	4	20	the	the	DET
gsrj-12	4	21	most	most	ADV
gsrj-12	4	22	compelling	compelling	ADJ
gsrj-12	4	23	mechanism	mechanism	NOUN
gsrj-12	4	24	to	to	PART
gsrj-12	4	25	discuss	discuss	VERB
gsrj-12	4	26	further	far	ADV
gsrj-12	4	27	.	.	PUNCT
gsrj-12	5	1	studying	study	VERB
gsrj-12	5	2	the	the	DET
gsrj-12	5	3	mechanisms	mechanism	NOUN
gsrj-12	5	4	of	of	ADP
gsrj-12	5	5	these	these	DET
gsrj-12	5	6	transporters	transporter	NOUN
gsrj-12	5	7	provides	provide	VERB
gsrj-12	5	8	critical	critical	ADJ
gsrj-12	5	9	insight	insight	NOUN
gsrj-12	5	10	for	for	ADP
gsrj-12	5	11	new	new	ADJ
gsrj-12	5	12	ways	way	NOUN
gsrj-12	5	13	to	to	PART
gsrj-12	5	14	combat	combat	NOUN
gsrj-12	5	15	pharmacoresistance	pharmacoresistance	NOUN
gsrj-12	5	16	.	.	PUNCT
gsrj-12	6	1	thus	thus	ADV
gsrj-12	6	2	,	,	PUNCT
gsrj-12	6	3	this	this	DET
gsrj-12	6	4	review	review	NOUN
gsrj-12	6	5	evaluates	evaluate	VERB
gsrj-12	6	6	the	the	DET
gsrj-12	6	7	co	co	NOUN
gsrj-12	6	8	-	-	NOUN
gsrj-12	6	9	administration	administration	NOUN
gsrj-12	6	10	of	of	ADP
gsrj-12	6	11	p	p	PROPN
gsrj-12	6	12	-	-	PUNCT
gsrj-12	6	13	gp	gp	NOUN
gsrj-12	6	14	inhibitors	inhibitor	NOUN
gsrj-12	6	15	with	with	ADP
gsrj-12	6	16	aeds	aed	NOUN
gsrj-12	6	17	as	as	ADP
gsrj-12	6	18	a	a	DET
gsrj-12	6	19	promising	promising	ADJ
gsrj-12	6	20	,	,	PUNCT
gsrj-12	6	21	yet	yet	CCONJ
gsrj-12	6	22	relatively	relatively	ADV
gsrj-12	6	23	unexplored	unexplored	ADJ
gsrj-12	6	24	,	,	PUNCT
gsrj-12	6	25	treatment	treatment	NOUN
gsrj-12	6	26	option	option	NOUN
gsrj-12	6	27	for	for	ADP
gsrj-12	6	28	refractory	refractory	NOUN
gsrj-12	6	29	epilepsy	epilepsy	NOUN
gsrj-12	6	30	.	.	PUNCT
gsrj-12	7	1	this	this	DET
gsrj-12	7	2	review	review	NOUN
gsrj-12	7	3	specifically	specifically	ADV
gsrj-12	7	4	considers	consider	VERB
gsrj-12	7	5	tariquidar	tariquidar	PRON
gsrj-12	7	6	(	(	PUNCT
gsrj-12	7	7	tqd	tqd	NOUN
gsrj-12	7	8	)	)	PUNCT
gsrj-12	7	9	the	the	DET
gsrj-12	7	10	most	most	ADV
gsrj-12	7	11	promising	promising	ADJ
gsrj-12	7	12	p	p	NOUN
gsrj-12	7	13	-	-	PUNCT
gsrj-12	7	14	gp	gp	NOUN
gsrj-12	7	15	inhibitor	inhibitor	NOUN
gsrj-12	7	16	for	for	ADP
gsrj-12	7	17	refractory	refractory	NOUN
gsrj-12	7	18	epilepsy	epilepsy	NOUN
gsrj-12	7	19	treatment	treatment	NOUN
gsrj-12	7	20	.	.	PUNCT
gsrj-12	8	1	this	this	DET
gsrj-12	8	2	work	work	NOUN
gsrj-12	8	3	aims	aim	VERB
gsrj-12	8	4	to	to	PART
gsrj-12	8	5	evaluate	evaluate	VERB
gsrj-12	8	6	the	the	DET
gsrj-12	8	7	role	role	NOUN
gsrj-12	8	8	of	of	ADP
gsrj-12	8	9	pgp	pgp	NOUN
gsrj-12	8	10	overexpression	overexpression	NOUN
gsrj-12	8	11	in	in	ADP
gsrj-12	8	12	refractory	refractory	NOUN
gsrj-12	8	13	epilepsy	epilepsy	NOUN
gsrj-12	8	14	,	,	PUNCT
gsrj-12	8	15	consolidate	consolidate	VERB
gsrj-12	8	16	current	current	ADJ
gsrj-12	8	17	research	research	NOUN
gsrj-12	8	18	about	about	ADP
gsrj-12	8	19	potential	potential	ADJ
gsrj-12	8	20	treatment	treatment	NOUN
gsrj-12	8	21	options	option	NOUN
gsrj-12	8	22	,	,	PUNCT
gsrj-12	8	23	and	and	CCONJ
gsrj-12	8	24	identify	identify	VERB
gsrj-12	8	25	discrepancies	discrepancy	NOUN
gsrj-12	8	26	or	or	CCONJ
gsrj-12	8	27	gaps	gap	NOUN
gsrj-12	8	28	in	in	ADP
gsrj-12	8	29	the	the	DET
gsrj-12	8	30	literature	literature	NOUN
gsrj-12	8	31	related	relate	VERB
gsrj-12	8	32	to	to	ADP
gsrj-12	8	33	p	p	NOUN
gsrj-12	8	34	-	-	PUNCT
gsrj-12	8	35	gp	gp	NOUN
gsrj-12	8	36	inhibitory	inhibitory	ADJ
gsrj-12	8	37	treatments	treatment	NOUN
gsrj-12	8	38	for	for	ADP
gsrj-12	8	39	refractory	refractory	NOUN
gsrj-12	8	40	epilepsy	epilepsy	NOUN
gsrj-12	8	41	.	.	PUNCT
gsrj-12	9	1	it	it	PRON
gsrj-12	9	2	was	be	AUX
gsrj-12	9	3	concluded	conclude	VERB
gsrj-12	9	4	that	that	SCONJ
gsrj-12	9	5	,	,	PUNCT
gsrj-12	9	6	as	as	ADP
gsrj-12	9	7	a	a	DET
gsrj-12	9	8	result	result	NOUN
gsrj-12	9	9	of	of	ADP
gsrj-12	9	10	increased	increase	VERB
gsrj-12	9	11	drug	drug	NOUN
gsrj-12	9	12	efflux	efflux	NOUN
gsrj-12	9	13	processes	process	NOUN
gsrj-12	9	14	at	at	ADP
gsrj-12	9	15	the	the	DET
gsrj-12	9	16	blood	blood	NOUN
gsrj-12	9	17	brain	brain	NOUN
gsrj-12	9	18	barrier	barrier	NOUN
gsrj-12	9	19	,	,	PUNCT
gsrj-12	9	20	overexpression	overexpression	NOUN
gsrj-12	9	21	of	of	ADP
gsrj-12	9	22	p	p	NOUN
gsrj-12	9	23	-	-	PUNCT
gsrj-12	9	24	gp	gp	NOUN
gsrj-12	9	25	is	be	AUX
gsrj-12	9	26	the	the	DET
gsrj-12	9	27	leading	lead	VERB
gsrj-12	9	28	cause	cause	NOUN
gsrj-12	9	29	of	of	ADP
gsrj-12	9	30	pharmacoresistance	pharmacoresistance	NOUN
gsrj-12	9	31	.	.	PUNCT
gsrj-12	10	1	by	by	ADP
gsrj-12	10	2	inhibiting	inhibit	VERB
gsrj-12	10	3	the	the	DET
gsrj-12	10	4	activity	activity	NOUN
gsrj-12	10	5	of	of	ADP
gsrj-12	10	6	these	these	DET
gsrj-12	10	7	proteins	protein	NOUN
gsrj-12	10	8	with	with	ADP
gsrj-12	10	9	the	the	DET
gsrj-12	10	10	drug	drug	NOUN
gsrj-12	10	11	tariquidar	tariquidar	NOUN
gsrj-12	10	12	,	,	PUNCT
gsrj-12	10	13	an	an	DET
gsrj-12	10	14	effective	effective	ADJ
gsrj-12	10	15	treatment	treatment	NOUN
gsrj-12	10	16	for	for	ADP
gsrj-12	10	17	refractory	refractory	NOUN
gsrj-12	10	18	epilepsy	epilepsy	NOUN
gsrj-12	10	19	may	may	AUX
gsrj-12	10	20	become	become	VERB
gsrj-12	10	21	a	a	DET
gsrj-12	10	22	reality	reality	NOUN
gsrj-12	10	23	.	.	PUNCT
gsrj-12	11	1	keywords	keyword	NOUN
gsrj-12	11	2	:	:	PUNCT
gsrj-12	11	3	refractory	refractory	NOUN
gsrj-12	11	4	epilepsy	epilepsy	PROPN
gsrj-12	11	5	,	,	PUNCT
gsrj-12	11	6	pharmacoresistance	pharmacoresistance	PROPN
gsrj-12	11	7	,	,	PUNCT
gsrj-12	11	8	overexpression	overexpression	NOUN
gsrj-12	11	9	,	,	PUNCT
gsrj-12	11	10	p	p	NOUN
gsrj-12	11	11	-	-	PUNCT
gsrj-12	11	12	glycoprotein	glycoprotein	NOUN
gsrj-12	11	13	,	,	PUNCT
gsrj-12	11	14	tariquidar	tariquidar	NOUN
gsrj-12	11	15	100	100	NUM
gsrj-12	11	16	georgetown	georgetown	PROPN
gsrj-12	11	17	scientific	scientific	PROPN
gsrj-12	11	18	research	research	NOUN
gsrj-12	11	19	journal	journal	NOUN
gsrj-12	11	20	https://doi.org/10.48091/uwyg8998	https://doi.org/10.48091/uwyg8998	PROPN
gsrj-12	11	21	1	1	X
gsrj-12	11	22	.	.	X
gsrj-12	12	1	introduction	introduction	NOUN
gsrj-12	12	2	epilepsy	epilepsy	NOUN
gsrj-12	12	3	is	be	AUX
gsrj-12	12	4	a	a	DET
gsrj-12	12	5	chronic	chronic	ADJ
gsrj-12	12	6	neurological	neurological	ADJ
gsrj-12	12	7	disorder	disorder	NOUN
gsrj-12	12	8	characterized	characterize	VERB
gsrj-12	12	9	by	by	ADP
gsrj-12	12	10	spontaneous	spontaneous	ADJ
gsrj-12	12	11	,	,	PUNCT
gsrj-12	12	12	repeated	repeat	VERB
gsrj-12	12	13	,	,	PUNCT
gsrj-12	12	14	and	and	CCONJ
gsrj-12	12	15	unprovoked	unprovoked	ADJ
gsrj-12	12	16	seizures	seizure	NOUN
gsrj-12	12	17	resulting	result	VERB
gsrj-12	12	18	from	from	ADP
gsrj-12	12	19	abnormal	abnormal	ADJ
gsrj-12	12	20	electrical	electrical	ADJ
gsrj-12	12	21	connections	connection	NOUN
gsrj-12	12	22	between	between	ADP
gsrj-12	12	23	neurons	neuron	NOUN
gsrj-12	12	24	in	in	ADP
gsrj-12	12	25	the	the	DET
gsrj-12	12	26	brain.1	brain.1	PROPN
gsrj-12	12	27	characterized	characterize	VERB
gsrj-12	12	28	by	by	ADP
gsrj-12	12	29	spontaneous	spontaneous	ADJ
gsrj-12	12	30	electrical	electrical	ADJ
gsrj-12	12	31	disturbances	disturbance	NOUN
gsrj-12	12	32	in	in	ADP
gsrj-12	12	33	the	the	DET
gsrj-12	12	34	brain	brain	NOUN
gsrj-12	12	35	,	,	PUNCT
gsrj-12	12	36	these	these	DET
gsrj-12	12	37	seizures	seizure	NOUN
gsrj-12	12	38	often	often	ADV
gsrj-12	12	39	result	result	VERB
gsrj-12	12	40	in	in	ADP
gsrj-12	12	41	physical	physical	ADJ
gsrj-12	12	42	manifestations	manifestation	NOUN
gsrj-12	12	43	such	such	ADJ
gsrj-12	12	44	as	as	ADP
gsrj-12	12	45	convulsion	convulsion	NOUN
gsrj-12	12	46	,	,	PUNCT
gsrj-12	12	47	loss	loss	NOUN
gsrj-12	12	48	of	of	ADP
gsrj-12	12	49	consciousness	consciousness	NOUN
gsrj-12	12	50	,	,	PUNCT
gsrj-12	12	51	sensory	sensory	ADJ
gsrj-12	12	52	disturbances	disturbance	NOUN
gsrj-12	12	53	,	,	PUNCT
gsrj-12	12	54	or	or	CCONJ
gsrj-12	12	55	uncontrolled	uncontrolled	ADJ
gsrj-12	12	56	movements.2	movements.2	ADJ
gsrj-12	12	57	epilepsy	epilepsy	NOUN
gsrj-12	12	58	encompasses	encompass	VERB
gsrj-12	12	59	many	many	ADJ
gsrj-12	12	60	different	different	ADJ
gsrj-12	12	61	types	type	NOUN
gsrj-12	12	62	of	of	ADP
gsrj-12	12	63	seizure	seizure	NOUN
gsrj-12	12	64	disorders	disorder	NOUN
gsrj-12	12	65	that	that	PRON
gsrj-12	12	66	are	be	AUX
gsrj-12	12	67	classified	classify	VERB
gsrj-12	12	68	according	accord	VERB
gsrj-12	12	69	to	to	ADP
gsrj-12	12	70	relative	relative	ADJ
gsrj-12	12	71	regions	region	NOUN
gsrj-12	12	72	of	of	ADP
gsrj-12	12	73	brain	brain	NOUN
gsrj-12	12	74	dysfunction	dysfunction	NOUN
gsrj-12	12	75	,	,	PUNCT
gsrj-12	12	76	types	type	NOUN
gsrj-12	12	77	of	of	ADP
gsrj-12	12	78	seizures	seizure	NOUN
gsrj-12	12	79	present	present	ADJ
gsrj-12	12	80	,	,	PUNCT
gsrj-12	12	81	and	and	CCONJ
gsrj-12	12	82	varying	vary	VERB
gsrj-12	12	83	degrees	degree	NOUN
gsrj-12	12	84	of	of	ADP
gsrj-12	12	85	causal	causal	ADJ
gsrj-12	12	86	explanation	explanation	NOUN
gsrj-12	12	87	.	.	PUNCT
gsrj-12	13	1	clinical	clinical	ADJ
gsrj-12	13	2	diagnosis	diagnosis	NOUN
gsrj-12	13	3	of	of	ADP
gsrj-12	13	4	epilepsy	epilepsy	NOUN
gsrj-12	13	5	requires	require	VERB
gsrj-12	13	6	at	at	ADV
gsrj-12	13	7	least	least	ADV
gsrj-12	13	8	two	two	NUM
gsrj-12	13	9	isolated	isolated	ADJ
gsrj-12	13	10	seizures	seizure	NOUN
gsrj-12	13	11	unrelated	unrelated	ADJ
gsrj-12	13	12	to	to	ADP
gsrj-12	13	13	brain	brain	NOUN
gsrj-12	13	14	injury	injury	NOUN
gsrj-12	13	15	,	,	PUNCT
gsrj-12	13	16	drug	drug	NOUN
gsrj-12	13	17	usage	usage	NOUN
gsrj-12	13	18	,	,	PUNCT
gsrj-12	13	19	metabolic	metabolic	NOUN
gsrj-12	13	20	disorders	disorder	NOUN
gsrj-12	13	21	,	,	PUNCT
gsrj-12	13	22	or	or	CCONJ
gsrj-12	13	23	acute	acute	ADJ
gsrj-12	13	24	systemic	systemic	PROPN
gsrj-12	13	25	dysfunction.3	dysfunction.3	PROPN
gsrj-12	13	26	impacting	impact	VERB
gsrj-12	13	27	2.2	2.2	NUM
gsrj-12	13	28	million	million	NUM
gsrj-12	13	29	people	people	NOUN
gsrj-12	13	30	in	in	ADP
gsrj-12	13	31	the	the	DET
gsrj-12	13	32	united	united	PROPN
gsrj-12	13	33	states	states	PROPN
gsrj-12	13	34	and	and	CCONJ
gsrj-12	13	35	over	over	ADP
gsrj-12	13	36	65	65	NUM
gsrj-12	13	37	million	million	NUM
gsrj-12	13	38	people	people	NOUN
gsrj-12	13	39	worldwide	worldwide	ADV
gsrj-12	13	40	,	,	PUNCT
gsrj-12	13	41	epilepsy	epilepsy	PROPN
gsrj-12	13	42	is	be	AUX
gsrj-12	13	43	the	the	DET
gsrj-12	13	44	most	most	ADV
gsrj-12	13	45	common	common	ADJ
gsrj-12	13	46	neurological	neurological	ADJ
gsrj-12	13	47	disorder	disorder	NOUN
gsrj-12	13	48	in	in	ADP
gsrj-12	13	49	the	the	DET
gsrj-12	13	50	world	world	NOUN
gsrj-12	13	51	.	.	PUNCT
gsrj-12	14	1	it	it	PRON
gsrj-12	14	2	accounts	account	VERB
gsrj-12	14	3	for	for	ADP
gsrj-12	14	4	0.5	0.5	NUM
gsrj-12	14	5	%	%	NOUN
gsrj-12	14	6	of	of	ADP
gsrj-12	14	7	the	the	DET
gsrj-12	14	8	global	global	ADJ
gsrj-12	14	9	burden	burden	NOUN
gsrj-12	14	10	of	of	ADP
gsrj-12	14	11	disease	disease	NOUN
gsrj-12	14	12	,	,	PUNCT
gsrj-12	14	13	a	a	DET
gsrj-12	14	14	measure	measure	NOUN
gsrj-12	14	15	that	that	PRON
gsrj-12	14	16	considers	consider	VERB
gsrj-12	14	17	the	the	DET
gsrj-12	14	18	number	number	NOUN
gsrj-12	14	19	of	of	ADP
gsrj-12	14	20	years	year	NOUN
gsrj-12	14	21	of	of	ADP
gsrj-12	14	22	life	life	NOUN
gsrj-12	14	23	lost	lose	VERB
gsrj-12	14	24	to	to	ADP
gsrj-12	14	25	premature	premature	VERB
gsrj-12	14	26	death	death	NOUN
gsrj-12	14	27	,	,	PUNCT
gsrj-12	14	28	illness	illness	NOUN
gsrj-12	14	29	,	,	PUNCT
gsrj-12	14	30	and	and	CCONJ
gsrj-12	14	31	disability	disability	NOUN
gsrj-12	14	32	.	.	PUNCT
gsrj-12	15	1	while	while	SCONJ
gsrj-12	15	2	this	this	DET
gsrj-12	15	3	condition	condition	NOUN
gsrj-12	15	4	is	be	AUX
gsrj-12	15	5	prevalent	prevalent	ADJ
gsrj-12	15	6	across	across	ADP
gsrj-12	15	7	all	all	DET
gsrj-12	15	8	age	age	NOUN
gsrj-12	15	9	demographics	demographic	NOUN
gsrj-12	15	10	,	,	PUNCT
gsrj-12	15	11	it	it	PRON
gsrj-12	15	12	disproportionately	disproportionately	ADV
gsrj-12	15	13	affects	affect	VERB
gsrj-12	15	14	individuals	individual	NOUN
gsrj-12	15	15	in	in	ADP
gsrj-12	15	16	early	early	ADJ
gsrj-12	15	17	childhood	childhood	NOUN
gsrj-12	15	18	or	or	CCONJ
gsrj-12	15	19	late	late	ADJ
gsrj-12	15	20	adulthood.3	adulthood.3	NOUN
gsrj-12	15	21	people	people	NOUN
gsrj-12	15	22	with	with	ADP
gsrj-12	15	23	epilepsy	epilepsy	NOUN
gsrj-12	15	24	are	be	AUX
gsrj-12	15	25	up	up	ADP
gsrj-12	15	26	to	to	PART
gsrj-12	15	27	three	three	NUM
gsrj-12	15	28	times	time	NOUN
gsrj-12	15	29	more	more	ADV
gsrj-12	15	30	likely	likely	ADJ
gsrj-12	15	31	to	to	PART
gsrj-12	15	32	experience	experience	VERB
gsrj-12	15	33	premature	premature	ADJ
gsrj-12	15	34	death	death	NOUN
gsrj-12	15	35	compared	compare	VERB
gsrj-12	15	36	to	to	ADP
gsrj-12	15	37	the	the	DET
gsrj-12	15	38	general	general	ADJ
gsrj-12	15	39	population	population	NOUN
gsrj-12	15	40	.	.	PUNCT
gsrj-12	16	1	1	1	NUM
gsrj-12	16	2	in	in	ADP
gsrj-12	16	3	every	every	DET
gsrj-12	16	4	1,000	1,000	NUM
gsrj-12	16	5	adults	adult	NOUN
gsrj-12	16	6	with	with	ADP
gsrj-12	16	7	epilepsy	epilepsy	NOUN
gsrj-12	16	8	suffer	suffer	VERB
gsrj-12	16	9	from	from	ADP
gsrj-12	16	10	sudden	sudden	ADJ
gsrj-12	16	11	unexpected	unexpected	ADJ
gsrj-12	16	12	death	death	NOUN
gsrj-12	16	13	in	in	ADP
gsrj-12	16	14	epilepsy	epilepsy	PROPN
gsrj-12	16	15	(	(	PUNCT
gsrj-12	16	16	sudep	sudep	NOUN
gsrj-12	16	17	)	)	PUNCT
gsrj-12	16	18	every	every	DET
gsrj-12	16	19	year	year	NOUN
gsrj-12	16	20	,	,	PUNCT
gsrj-12	16	21	and	and	CCONJ
gsrj-12	16	22	those	those	PRON
gsrj-12	16	23	with	with	ADP
gsrj-12	16	24	drugresistant	drugresistant	NOUN
gsrj-12	16	25	forms	form	NOUN
gsrj-12	16	26	are	be	AUX
gsrj-12	16	27	at	at	ADP
gsrj-12	16	28	increased	increase	VERB
gsrj-12	16	29	risk	risk	NOUN
gsrj-12	16	30	of	of	ADP
gsrj-12	16	31	sudep	sudep	NOUN
gsrj-12	16	32	.	.	PUNCT
gsrj-12	17	1	in	in	ADP
gsrj-12	17	2	the	the	DET
gsrj-12	17	3	united	united	PROPN
gsrj-12	17	4	states	states	PROPN
gsrj-12	17	5	alone	alone	ADV
gsrj-12	17	6	,	,	PUNCT
gsrj-12	17	7	over	over	ADP
gsrj-12	17	8	150,000	150,000	NUM
gsrj-12	17	9	new	new	ADJ
gsrj-12	17	10	cases	case	NOUN
gsrj-12	17	11	of	of	ADP
gsrj-12	17	12	epilepsy	epilepsy	NOUN
gsrj-12	17	13	are	be	AUX
gsrj-12	17	14	diagnosed	diagnose	VERB
gsrj-12	17	15	annually	annually	ADV
gsrj-12	17	16	and	and	CCONJ
gsrj-12	17	17	one	one	NUM
gsrj-12	17	18	in	in	ADP
gsrj-12	17	19	26	26	NUM
gsrj-12	17	20	individuals	individual	NOUN
gsrj-12	17	21	are	be	AUX
gsrj-12	17	22	projected	project	VERB
gsrj-12	17	23	to	to	PART
gsrj-12	17	24	develop	develop	VERB
gsrj-12	17	25	epilepsy	epilepsy	NOUN
gsrj-12	17	26	over	over	ADP
gsrj-12	17	27	the	the	DET
gsrj-12	17	28	course	course	NOUN
gsrj-12	17	29	of	of	ADP
gsrj-12	17	30	their	their	PRON
gsrj-12	17	31	lifetimes	lifetime	NOUN
gsrj-12	17	32	.	.	PUNCT
gsrj-12	18	1	direct	direct	ADJ
gsrj-12	18	2	annual	annual	ADJ
gsrj-12	18	3	medical	medical	ADJ
gsrj-12	18	4	care	care	NOUN
gsrj-12	18	5	costs	cost	NOUN
gsrj-12	18	6	of	of	ADP
gsrj-12	18	7	epilepsy	epilepsy	NOUN
gsrj-12	18	8	in	in	ADP
gsrj-12	18	9	the	the	DET
gsrj-12	18	10	united	united	PROPN
gsrj-12	18	11	states	states	PROPN
gsrj-12	18	12	total	total	VERB
gsrj-12	18	13	$	$	SYM
gsrj-12	18	14	9.6	9.6	NUM
gsrj-12	18	15	billion	billion	NUM
gsrj-12	18	16	and	and	CCONJ
gsrj-12	18	17	contribute	contribute	VERB
gsrj-12	18	18	significant	significant	ADJ
gsrj-12	18	19	financial	financial	ADJ
gsrj-12	18	20	burden	burden	NOUN
gsrj-12	18	21	to	to	ADP
gsrj-12	18	22	sufferers.3	sufferers.3	PROPN
gsrj-12	18	23	along	along	ADP
gsrj-12	18	24	with	with	ADP
gsrj-12	18	25	the	the	DET
gsrj-12	18	26	difficulties	difficulty	NOUN
gsrj-12	18	27	associated	associate	VERB
gsrj-12	18	28	with	with	ADP
gsrj-12	18	29	seizures	seizure	NOUN
gsrj-12	18	30	and	and	CCONJ
gsrj-12	18	31	other	other	ADJ
gsrj-12	18	32	related	related	ADJ
gsrj-12	18	33	symptoms	symptom	NOUN
gsrj-12	18	34	,	,	PUNCT
gsrj-12	18	35	people	people	NOUN
gsrj-12	18	36	living	live	VERB
gsrj-12	18	37	with	with	ADP
gsrj-12	18	38	epilepsy	epilepsy	NOUN
gsrj-12	18	39	are	be	AUX
gsrj-12	18	40	often	often	ADV
gsrj-12	18	41	faced	face	VERB
gsrj-12	18	42	with	with	ADP
gsrj-12	18	43	challenges	challenge	NOUN
gsrj-12	18	44	accessing	access	VERB
gsrj-12	18	45	high	high	ADJ
gsrj-12	18	46	-	-	PUNCT
gsrj-12	18	47	quality	quality	NOUN
gsrj-12	18	48	healthcare	healthcare	NOUN
gsrj-12	18	49	,	,	PUNCT
gsrj-12	18	50	navigating	navigate	VERB
gsrj-12	18	51	treatment	treatment	NOUN
gsrj-12	18	52	options	option	NOUN
gsrj-12	18	53	,	,	PUNCT
gsrj-12	18	54	and	and	CCONJ
gsrj-12	18	55	dealing	deal	VERB
gsrj-12	18	56	with	with	ADP
gsrj-12	18	57	public	public	ADJ
gsrj-12	18	58	misunderstanding	misunderstanding	NOUN
gsrj-12	18	59	of	of	ADP
gsrj-12	18	60	the	the	DET
gsrj-12	18	61	disease	disease	NOUN
gsrj-12	18	62	.	.	PUNCT
gsrj-12	19	1	in	in	ADP
gsrj-12	19	2	many	many	ADJ
gsrj-12	19	3	areas	area	NOUN
gsrj-12	19	4	across	across	ADP
gsrj-12	19	5	the	the	DET
gsrj-12	19	6	globe	globe	NOUN
gsrj-12	19	7	,	,	PUNCT
gsrj-12	19	8	people	people	NOUN
gsrj-12	19	9	with	with	ADP
gsrj-12	19	10	epilepsy	epilepsy	NOUN
gsrj-12	19	11	also	also	ADV
gsrj-12	19	12	experience	experience	VERB
gsrj-12	19	13	reduced	reduce	VERB
gsrj-12	19	14	access	access	NOUN
gsrj-12	19	15	to	to	ADP
gsrj-12	19	16	educational	educational	ADJ
gsrj-12	19	17	and	and	CCONJ
gsrj-12	19	18	vocational	vocational	ADJ
gsrj-12	19	19	opportunities	opportunity	NOUN
gsrj-12	19	20	as	as	ADP
gsrj-12	19	21	a	a	DET
gsrj-12	19	22	result	result	NOUN
gsrj-12	19	23	of	of	ADP
gsrj-12	19	24	stigma	stigma	NOUN
gsrj-12	19	25	and	and	CCONJ
gsrj-12	19	26	discrimination	discrimination	NOUN
gsrj-12	19	27	associated	associate	VERB
gsrj-12	19	28	with	with	ADP
gsrj-12	19	29	the	the	DET
gsrj-12	19	30	disease.2	disease.2	PROPN
gsrj-12	19	31	this	this	PRON
gsrj-12	19	32	emphasizes	emphasize	VERB
gsrj-12	19	33	the	the	DET
gsrj-12	19	34	need	need	NOUN
gsrj-12	19	35	to	to	PART
gsrj-12	19	36	find	find	VERB
gsrj-12	19	37	treatments	treatment	NOUN
gsrj-12	19	38	or	or	CCONJ
gsrj-12	19	39	cures	cure	NOUN
gsrj-12	19	40	for	for	ADP
gsrj-12	19	41	epilepsy	epilepsy	NOUN
gsrj-12	19	42	.	.	PUNCT
gsrj-12	20	1	in	in	ADP
gsrj-12	20	2	doing	do	VERB
gsrj-12	20	3	so	so	ADV
gsrj-12	20	4	,	,	PUNCT
gsrj-12	20	5	the	the	DET
gsrj-12	20	6	detrimental	detrimental	ADJ
gsrj-12	20	7	impacts	impact	NOUN
gsrj-12	20	8	of	of	ADP
gsrj-12	20	9	the	the	DET
gsrj-12	20	10	condition	condition	NOUN
gsrj-12	20	11	and	and	CCONJ
gsrj-12	20	12	the	the	DET
gsrj-12	20	13	socioeconomic	socioeconomic	ADJ
gsrj-12	20	14	disparities	disparity	NOUN
gsrj-12	20	15	associated	associate	VERB
gsrj-12	20	16	with	with	ADP
gsrj-12	20	17	it	it	PRON
gsrj-12	20	18	may	may	AUX
gsrj-12	20	19	be	be	AUX
gsrj-12	20	20	relieved	relieve	VERB
gsrj-12	20	21	.	.	PUNCT
gsrj-12	21	1	while	while	SCONJ
gsrj-12	21	2	there	there	PRON
gsrj-12	21	3	are	be	VERB
gsrj-12	21	4	numerous	numerous	ADJ
gsrj-12	21	5	therapeutic	therapeutic	ADJ
gsrj-12	21	6	options	option	NOUN
gsrj-12	21	7	available	available	ADJ
gsrj-12	21	8	to	to	PART
gsrj-12	21	9	treat	treat	VERB
gsrj-12	21	10	epilepsy	epilepsy	NOUN
gsrj-12	21	11	—	—	PUNCT
gsrj-12	21	12	such	such	ADJ
gsrj-12	21	13	as	as	ADP
gsrj-12	21	14	antiepileptic	antiepileptic	ADJ
gsrj-12	21	15	drugs	drug	NOUN
gsrj-12	21	16	(	(	PUNCT
gsrj-12	21	17	aeds	aed	NOUN
gsrj-12	21	18	)	)	PUNCT
gsrj-12	21	19	,	,	PUNCT
gsrj-12	21	20	surgical	surgical	ADJ
gsrj-12	21	21	intervention	intervention	NOUN
gsrj-12	21	22	,	,	PUNCT
gsrj-12	21	23	nerve	nerve	NOUN
gsrj-12	21	24	stimulation	stimulation	NOUN
gsrj-12	21	25	,	,	PUNCT
gsrj-12	21	26	or	or	CCONJ
gsrj-12	21	27	specialized	specialized	ADJ
gsrj-12	21	28	diets	diet	NOUN
gsrj-12	21	29	—	—	PUNCT
gsrj-12	21	30	treatment	treatment	NOUN
gsrj-12	21	31	methods	method	NOUN
gsrj-12	21	32	are	be	AUX
gsrj-12	21	33	often	often	ADV
gsrj-12	21	34	ineffective	ineffective	ADJ
gsrj-12	21	35	.	.	PUNCT
gsrj-12	22	1	over	over	ADP
gsrj-12	22	2	one	one	NUM
gsrj-12	22	3	-	-	PUNCT
gsrj-12	22	4	third	third	NOUN
gsrj-12	22	5	of	of	ADP
gsrj-12	22	6	people	people	NOUN
gsrj-12	22	7	diagnosed	diagnose	VERB
gsrj-12	22	8	with	with	ADP
gsrj-12	22	9	epilepsy	epilepsy	NOUN
gsrj-12	22	10	will	will	AUX
gsrj-12	22	11	develop	develop	VERB
gsrj-12	22	12	refractory	refractory	NOUN
gsrj-12	22	13	(	(	PUNCT
gsrj-12	22	14	drug	drug	NOUN
gsrj-12	22	15	-	-	PUNCT
gsrj-12	22	16	resistant	resistant	ADJ
gsrj-12	22	17	)	)	PUNCT
gsrj-12	22	18	epilepsy	epilepsy	NOUN
gsrj-12	22	19	as	as	ADP
gsrj-12	22	20	a	a	DET
gsrj-12	22	21	result	result	NOUN
gsrj-12	22	22	of	of	ADP
gsrj-12	22	23	pharmacoresistance	pharmacoresistance	PROPN
gsrj-12	22	24	,	,	PUNCT
gsrj-12	22	25	the	the	DET
gsrj-12	22	26	inability	inability	NOUN
gsrj-12	22	27	to	to	PART
gsrj-12	22	28	control	control	VERB
gsrj-12	22	29	seizure	seizure	NOUN
gsrj-12	22	30	activity	activity	NOUN
gsrj-12	22	31	through	through	ADP
gsrj-12	22	32	aed	aed	NOUN
gsrj-12	22	33	therapy.4	therapy.4	NOUN
gsrj-12	22	34	this	this	DET
gsrj-12	22	35	form	form	NOUN
gsrj-12	22	36	of	of	ADP
gsrj-12	22	37	epilepsy	epilepsy	NOUN
gsrj-12	22	38	is	be	AUX
gsrj-12	22	39	clinically	clinically	ADV
gsrj-12	22	40	diagnosed	diagnose	VERB
gsrj-12	22	41	after	after	SCONJ
gsrj-12	22	42	two	two	NUM
gsrj-12	22	43	trials	trial	NOUN
gsrj-12	22	44	of	of	ADP
gsrj-12	22	45	aeds	aed	NOUN
gsrj-12	22	46	fail	fail	VERB
gsrj-12	22	47	to	to	PART
gsrj-12	22	48	manage	manage	VERB
gsrj-12	22	49	or	or	CCONJ
gsrj-12	22	50	cease	cease	VERB
gsrj-12	22	51	seizure	seizure	NOUN
gsrj-12	22	52	activity	activity	NOUN
gsrj-12	22	53	.	.	PUNCT
gsrj-12	23	1	while	while	SCONJ
gsrj-12	23	2	about	about	ADV
gsrj-12	23	3	50	50	NUM
gsrj-12	23	4	%	%	NOUN
gsrj-12	23	5	of	of	ADP
gsrj-12	23	6	newly	newly	ADV
gsrj-12	23	7	diagnosed	diagnose	VERB
gsrj-12	23	8	epileptic	epileptic	ADJ
gsrj-12	23	9	patients	patient	NOUN
gsrj-12	23	10	obtain	obtain	VERB
gsrj-12	23	11	full	full	ADJ
gsrj-12	23	12	seizure	seizure	NOUN
gsrj-12	23	13	control	control	NOUN
gsrj-12	23	14	within	within	ADP
gsrj-12	23	15	the	the	DET
gsrj-12	23	16	first	first	ADJ
gsrj-12	23	17	aed	aed	NOUN
gsrj-12	23	18	treatment	treatment	NOUN
gsrj-12	23	19	and	and	CCONJ
gsrj-12	23	20	13	13	NUM
gsrj-12	23	21	%	%	NOUN
gsrj-12	23	22	after	after	ADP
gsrj-12	23	23	switching	switch	VERB
gsrj-12	23	24	to	to	ADP
gsrj-12	23	25	a	a	DET
gsrj-12	23	26	second	second	ADJ
gsrj-12	23	27	aed	aed	NOUN
gsrj-12	23	28	treatment	treatment	NOUN
gsrj-12	23	29	,	,	PUNCT
gsrj-12	23	30	20	20	NUM
gsrj-12	23	31	-	-	SYM
gsrj-12	23	32	25	25	NUM
gsrj-12	23	33	%	%	NOUN
gsrj-12	23	34	of	of	ADP
gsrj-12	23	35	total	total	ADJ
gsrj-12	23	36	patients	patient	NOUN
gsrj-12	23	37	still	still	ADV
gsrj-12	23	38	do	do	AUX
gsrj-12	23	39	not	not	PART
gsrj-12	23	40	see	see	VERB
gsrj-12	23	41	improvement	improvement	NOUN
gsrj-12	23	42	after	after	SCONJ
gsrj-12	23	43	a	a	DET
gsrj-12	23	44	single	single	ADJ
gsrj-12	23	45	aed	aed	NOUN
gsrj-12	23	46	or	or	CCONJ
gsrj-12	23	47	a	a	DET
gsrj-12	23	48	combination	combination	NOUN
gsrj-12	23	49	of	of	ADP
gsrj-12	23	50	aeds.5	aeds.5	PROPN
gsrj-12	23	51	management	management	NOUN
gsrj-12	23	52	of	of	ADP
gsrj-12	23	53	refractory	refractory	NOUN
gsrj-12	23	54	epilepsy	epilepsy	NOUN
gsrj-12	23	55	is	be	AUX
gsrj-12	23	56	particularly	particularly	ADV
gsrj-12	23	57	challenging	challenging	ADJ
gsrj-12	23	58	because	because	SCONJ
gsrj-12	23	59	there	there	PRON
gsrj-12	23	60	is	be	VERB
gsrj-12	23	61	little	little	ADJ
gsrj-12	23	62	conclusive	conclusive	ADJ
gsrj-12	23	63	evidence	evidence	NOUN
gsrj-12	23	64	about	about	ADP
gsrj-12	23	65	the	the	DET
gsrj-12	23	66	causes	cause	NOUN
gsrj-12	23	67	or	or	CCONJ
gsrj-12	23	68	mechanisms	mechanism	NOUN
gsrj-12	23	69	of	of	ADP
gsrj-12	23	70	pharmacoresistance	pharmacoresistance	NOUN
gsrj-12	23	71	,	,	PUNCT
gsrj-12	23	72	and	and	CCONJ
gsrj-12	23	73	individualized	individualized	ADJ
gsrj-12	23	74	treatment	treatment	NOUN
gsrj-12	23	75	plans	plan	NOUN
gsrj-12	23	76	are	be	AUX
gsrj-12	23	77	necessary	necessary	ADJ
gsrj-12	23	78	due	due	ADP
gsrj-12	23	79	to	to	ADP
gsrj-12	23	80	different	different	ADJ
gsrj-12	23	81	underlying	underlie	VERB
gsrj-12	23	82	disease	disease	NOUN
gsrj-12	23	83	mechanisms.6	mechanisms.6	PROPN
gsrj-12	23	84	some	some	DET
gsrj-12	23	85	possible	possible	ADJ
gsrj-12	23	86	causes	cause	NOUN
gsrj-12	23	87	for	for	ADP
gsrj-12	23	88	drug	drug	NOUN
gsrj-12	23	89	-	-	PUNCT
gsrj-12	23	90	resistance	resistance	NOUN
gsrj-12	23	91	may	may	AUX
gsrj-12	23	92	include	include	VERB
gsrj-12	23	93	environmental	environmental	ADJ
gsrj-12	23	94	factors	factor	NOUN
gsrj-12	23	95	,	,	PUNCT
gsrj-12	23	96	including	include	VERB
gsrj-12	23	97	trauma	trauma	NOUN
gsrj-12	23	98	and	and	CCONJ
gsrj-12	23	99	prior	prior	ADJ
gsrj-12	23	100	drug	drug	NOUN
gsrj-12	23	101	exposure	exposure	NOUN
gsrj-12	23	102	,	,	PUNCT
gsrj-12	23	103	or	or	CCONJ
gsrj-12	23	104	genetic	genetic	ADJ
gsrj-12	23	105	predispositions	predisposition	NOUN
gsrj-12	23	106	that	that	PRON
gsrj-12	23	107	impact	impact	VERB
gsrj-12	23	108	the	the	DET
gsrj-12	23	109	degree	degree	NOUN
gsrj-12	23	110	of	of	ADP
gsrj-12	23	111	absorption	absorption	NOUN
gsrj-12	23	112	,	,	PUNCT
gsrj-12	23	113	metabolism	metabolism	NOUN
gsrj-12	23	114	,	,	PUNCT
gsrj-12	23	115	and	and	CCONJ
gsrj-12	23	116	uptake	uptake	NOUN
gsrj-12	23	117	of	of	ADP
gsrj-12	23	118	aeds	aed	NOUN
gsrj-12	23	119	at	at	ADP
gsrj-12	23	120	the	the	DET
gsrj-12	23	121	blood	blood	NOUN
gsrj-12	23	122	brain	brain	NOUN
gsrj-12	23	123	barrier	barrier	NOUN
gsrj-12	23	124	.	.	PUNCT
gsrj-12	24	1	most	most	ADJ
gsrj-12	24	2	of	of	ADP
gsrj-12	24	3	the	the	DET
gsrj-12	24	4	current	current	ADJ
gsrj-12	24	5	research	research	NOUN
gsrj-12	24	6	on	on	ADP
gsrj-12	24	7	the	the	DET
gsrj-12	24	8	mechanisms	mechanism	NOUN
gsrj-12	24	9	of	of	ADP
gsrj-12	24	10	refractory	refractory	NOUN
gsrj-12	24	11	epilepsy	epilepsy	NOUN
gsrj-12	24	12	suggests	suggest	VERB
gsrj-12	24	13	that	that	SCONJ
gsrj-12	24	14	drug	drug	NOUN
gsrj-12	24	15	-	-	PUNCT
gsrj-12	24	16	resistance	resistance	NOUN
gsrj-12	24	17	in	in	ADP
gsrj-12	24	18	epilepsy	epilepsy	NOUN
gsrj-12	24	19	is	be	AUX
gsrj-12	24	20	caused	cause	VERB
gsrj-12	24	21	by	by	ADP
gsrj-12	24	22	increased	increase	VERB
gsrj-12	24	23	activity	activity	NOUN
gsrj-12	24	24	and	and	CCONJ
gsrj-12	24	25	expression	expression	NOUN
gsrj-12	24	26	of	of	ADP
gsrj-12	24	27	multidrug	multidrug	NOUN
gsrj-12	24	28	efflux	efflux	NOUN
gsrj-12	24	29	transporter	transporter	NOUN
gsrj-12	24	30	proteins	protein	NOUN
gsrj-12	24	31	in	in	ADP
gsrj-12	24	32	the	the	DET
gsrj-12	24	33	atp	atp	NOUN
gsrj-12	24	34	-	-	PUNCT
gsrj-12	24	35	binding	bind	VERB
gsrj-12	24	36	cassette	cassette	NOUN
gsrj-12	24	37	(	(	PUNCT
gsrj-12	24	38	abc	abc	PROPN
gsrj-12	24	39	)	)	PUNCT
gsrj-12	24	40	protein	protein	NOUN
gsrj-12	24	41	transporter	transporter	NOUN
gsrj-12	24	42	family.7	family.7	NOUN
gsrj-12	24	43	there	there	PRON
gsrj-12	24	44	are	be	VERB
gsrj-12	24	45	three	three	NUM
gsrj-12	24	46	major	major	ADJ
gsrj-12	24	47	types	type	NOUN
gsrj-12	24	48	of	of	ADP
gsrj-12	24	49	abc	abc	PROPN
gsrj-12	24	50	transporters	transporter	NOUN
gsrj-12	24	51	that	that	PRON
gsrj-12	24	52	play	play	VERB
gsrj-12	24	53	a	a	DET
gsrj-12	24	54	101	101	NUM
gsrj-12	24	55	georgetown	georgetown	PROPN
gsrj-12	24	56	scientific	scientific	PROPN
gsrj-12	24	57	research	research	NOUN
gsrj-12	24	58	journal	journal	PROPN
gsrj-12	24	59	https://doi.org/10.48091/uwyg8998	https://doi.org/10.48091/uwyg8998	VERB
gsrj-12	24	60	significant	significant	ADJ
gsrj-12	24	61	role	role	NOUN
gsrj-12	24	62	in	in	ADP
gsrj-12	24	63	the	the	DET
gsrj-12	24	64	failure	failure	NOUN
gsrj-12	24	65	of	of	ADP
gsrj-12	24	66	aeds	aed	NOUN
gsrj-12	24	67	to	to	PART
gsrj-12	24	68	control	control	VERB
gsrj-12	24	69	refractory	refractory	NOUN
gsrj-12	24	70	epilepsy	epilepsy	NOUN
gsrj-12	24	71	seizures	seizure	NOUN
gsrj-12	24	72	:	:	PUNCT
gsrj-12	24	73	permeabilityglycoproteins	permeabilityglycoprotein	NOUN
gsrj-12	24	74	(	(	PUNCT
gsrj-12	24	75	p	p	NOUN
gsrj-12	24	76	-	-	PUNCT
gsrj-12	24	77	glycoproteins	glycoprotein	NOUN
gsrj-12	24	78	or	or	CCONJ
gsrj-12	24	79	p	p	NOUN
gsrj-12	24	80	-	-	PUNCT
gsrj-12	24	81	gps	gps	NOUN
gsrj-12	24	82	)	)	PUNCT
gsrj-12	24	83	,	,	PUNCT
gsrj-12	24	84	multidrug	multidrug	VERB
gsrj-12	24	85	resistant	resistant	ADJ
gsrj-12	24	86	-	-	PUNCT
gsrj-12	24	87	associated	associate	VERB
gsrj-12	24	88	proteins	protein	NOUN
gsrj-12	24	89	(	(	PUNCT
gsrj-12	24	90	mrps	mrps	PROPN
gsrj-12	24	91	)	)	PUNCT
gsrj-12	24	92	,	,	PUNCT
gsrj-12	24	93	or	or	CCONJ
gsrj-12	24	94	breast	breast	NOUN
gsrj-12	24	95	cancer	cancer	NOUN
gsrj-12	24	96	resistant	resistant	ADJ
gsrj-12	24	97	proteins	protein	NOUN
gsrj-12	24	98	(	(	PUNCT
gsrj-12	24	99	bcrps).7	bcrps).7	VERB
gsrj-12	24	100	these	these	DET
gsrj-12	24	101	active	active	ADJ
gsrj-12	24	102	transporters	transporter	NOUN
gsrj-12	24	103	use	use	VERB
gsrj-12	24	104	the	the	DET
gsrj-12	24	105	energy	energy	NOUN
gsrj-12	24	106	of	of	ADP
gsrj-12	24	107	atp	atp	PROPN
gsrj-12	24	108	through	through	ADP
gsrj-12	24	109	atp	atp	NOUN
gsrj-12	24	110	hydrolysis	hydrolysis	NOUN
gsrj-12	24	111	to	to	PART
gsrj-12	24	112	allow	allow	VERB
gsrj-12	24	113	for	for	ADP
gsrj-12	24	114	the	the	DET
gsrj-12	24	115	movement	movement	NOUN
gsrj-12	24	116	of	of	ADP
gsrj-12	24	117	molecules	molecule	NOUN
gsrj-12	24	118	across	across	ADP
gsrj-12	24	119	a	a	DET
gsrj-12	24	120	membrane	membrane	NOUN
gsrj-12	24	121	,	,	PUNCT
gsrj-12	24	122	although	although	SCONJ
gsrj-12	24	123	abc	abc	PROPN
gsrj-12	24	124	transporters	transporter	NOUN
gsrj-12	24	125	specifically	specifically	ADV
gsrj-12	24	126	use	use	VERB
gsrj-12	24	127	an	an	DET
gsrj-12	24	128	alternate	alternate	ADJ
gsrj-12	24	129	access	access	NOUN
gsrj-12	24	130	mechanism	mechanism	NOUN
gsrj-12	24	131	,	,	PUNCT
gsrj-12	24	132	which	which	PRON
gsrj-12	24	133	entails	entail	VERB
gsrj-12	24	134	switching	switch	VERB
gsrj-12	24	135	between	between	ADP
gsrj-12	24	136	“	"	PUNCT
gsrj-12	24	137	inwardand	inwardand	VERB
gsrj-12	24	138	outward	outward	ADV
gsrj-12	24	139	-	-	PUNCT
gsrj-12	24	140	facing	face	VERB
gsrj-12	24	141	states	state	NOUN
gsrj-12	24	142	”	"	PUNCT
gsrj-12	24	143	at	at	ADP
gsrj-12	24	144	the	the	DET
gsrj-12	24	145	membrane	membrane	NOUN
gsrj-12	24	146	which	which	PRON
gsrj-12	24	147	,	,	PUNCT
gsrj-12	24	148	in	in	ADP
gsrj-12	24	149	turn	turn	NOUN
gsrj-12	24	150	,	,	PUNCT
gsrj-12	24	151	alternates	alternate	VERB
gsrj-12	24	152	whether	whether	SCONJ
gsrj-12	24	153	the	the	DET
gsrj-12	24	154	ligand	ligand	NOUN
gsrj-12	24	155	-	-	PUNCT
gsrj-12	24	156	binding	bind	VERB
gsrj-12	24	157	site	site	NOUN
gsrj-12	24	158	is	be	AUX
gsrj-12	24	159	exposed	expose	VERB
gsrj-12	24	160	inside	inside	ADP
gsrj-12	24	161	or	or	CCONJ
gsrj-12	24	162	outside	outside	ADP
gsrj-12	24	163	the	the	DET
gsrj-12	24	164	membrane.8	membrane.8	PROPN
gsrj-12	24	165	many	many	ADJ
gsrj-12	24	166	studies	study	NOUN
gsrj-12	24	167	suggest	suggest	VERB
gsrj-12	24	168	this	this	DET
gsrj-12	24	169	group	group	NOUN
gsrj-12	24	170	of	of	ADP
gsrj-12	24	171	abc	abc	PROPN
gsrj-12	24	172	transporters	transporter	NOUN
gsrj-12	24	173	and	and	CCONJ
gsrj-12	24	174	their	their	PRON
gsrj-12	24	175	related	relate	VERB
gsrj-12	24	176	efflux	efflux	NOUN
gsrj-12	24	177	mechanisms	mechanism	NOUN
gsrj-12	24	178	to	to	PART
gsrj-12	24	179	be	be	AUX
gsrj-12	24	180	the	the	DET
gsrj-12	24	181	major	major	ADJ
gsrj-12	24	182	cause	cause	NOUN
gsrj-12	24	183	of	of	ADP
gsrj-12	24	184	pharmacoresistance	pharmacoresistance	NOUN
gsrj-12	24	185	in	in	ADP
gsrj-12	24	186	refractory	refractory	NOUN
gsrj-12	24	187	epilepsy	epilepsy	NOUN
gsrj-12	24	188	,	,	PUNCT
gsrj-12	24	189	and	and	CCONJ
gsrj-12	24	190	the	the	DET
gsrj-12	24	191	most	most	ADV
gsrj-12	24	192	compelling	compelling	ADJ
gsrj-12	24	193	evidence	evidence	NOUN
gsrj-12	24	194	 	 	SPACE
gsrj-12	24	195	suggests	suggest	VERB
gsrj-12	24	196	that	that	SCONJ
gsrj-12	24	197	the	the	DET
gsrj-12	24	198	overexpression	overexpression	NOUN
gsrj-12	24	199	,	,	PUNCT
gsrj-12	24	200	or	or	CCONJ
gsrj-12	24	201	increased	increase	VERB
gsrj-12	24	202	expression	expression	NOUN
gsrj-12	24	203	,	,	PUNCT
gsrj-12	24	204	of	of	ADP
gsrj-12	24	205	pglycoprotein	pglycoprotein	ADJ
gsrj-12	24	206	transporters	transporter	NOUN
gsrj-12	24	207	most	most	ADV
gsrj-12	24	208	significantly	significantly	ADV
gsrj-12	24	209	reduces	reduce	VERB
gsrj-12	24	210	uptake	uptake	NOUN
gsrj-12	24	211	of	of	ADP
gsrj-12	24	212	aeds	aed	NOUN
gsrj-12	24	213	at	at	ADP
gsrj-12	24	214	the	the	DET
gsrj-12	24	215	blood	blood	NOUN
gsrj-12	24	216	brain	brain	NOUN
gsrj-12	24	217	barrier.7,9	barrier.7,9	PROPN
gsrj-12	24	218	additional	additional	ADJ
gsrj-12	24	219	studies	study	NOUN
gsrj-12	24	220	have	have	AUX
gsrj-12	24	221	shown	show	VERB
gsrj-12	24	222	that	that	SCONJ
gsrj-12	24	223	the	the	DET
gsrj-12	24	224	inhibition	inhibition	NOUN
gsrj-12	24	225	of	of	ADP
gsrj-12	24	226	these	these	DET
gsrj-12	24	227	particular	particular	ADJ
gsrj-12	24	228	p	p	ADJ
gsrj-12	24	229	-	-	PUNCT
gsrj-12	24	230	gp	gp	NOUN
gsrj-12	24	231	transporters	transporter	NOUN
gsrj-12	24	232	can	can	AUX
gsrj-12	24	233	reduce	reduce	VERB
gsrj-12	24	234	efflux	efflux	NOUN
gsrj-12	24	235	transporter	transporter	NOUN
gsrj-12	24	236	mechanisms	mechanism	NOUN
gsrj-12	24	237	and	and	CCONJ
gsrj-12	24	238	,	,	PUNCT
gsrj-12	24	239	subsequently	subsequently	ADV
gsrj-12	24	240	,	,	PUNCT
gsrj-12	24	241	can	can	AUX
gsrj-12	24	242	potentially	potentially	ADV
gsrj-12	24	243	�	�	VERB
gsrj-12	24	244	eliminate	eliminate	VERB
gsrj-12	24	245	pharmacoresistance	pharmacoresistance	NOUN
gsrj-12	24	246	altogether	altogether	ADV
gsrj-12	24	247	.	.	PUNCT
gsrj-12	25	1	�	�	PROPN
gsrj-12	25	2	�	�	PROPN
gsrj-12	25	3	*	*	PUNCT
gsrj-12	25	4	o	o	NOUN
gsrj-12	25	5	�	�	PROPN
gsrj-12	25	6	essence	essence	NOUN
gsrj-12	25	7	,	,	PUNCT
gsrj-12	25	8	the	the	DET
gsrj-12	25	9	overexpression	overexpression	NOUN
gsrj-12	25	10	of	of	ADP
gsrj-12	25	11	pglycoproteins	pglycoprotein	NOUN
gsrj-12	25	12	in	in	ADP
gsrj-12	25	13	the	the	DET
gsrj-12	25	14	brain	brain	NOUN
gsrj-12	25	15	leading	lead	VERB
gsrj-12	25	16	to	to	ADP
gsrj-12	25	17	the	the	DET
gsrj-12	25	18	reduced	reduce	VERB
gsrj-12	25	19	uptake	uptake	NOUN
gsrj-12	25	20	of	of	ADP
gsrj-12	25	21	aeds	aed	NOUN
gsrj-12	25	22	at	at	ADP
gsrj-12	25	23	the	the	DET
gsrj-12	25	24	blood	blood	NOUN
gsrj-12	25	25	brain	brain	NOUN
gsrj-12	25	26	barrier	barrier	NOUN
gsrj-12	25	27	is	be	AUX
gsrj-12	25	28	the	the	DET
gsrj-12	25	29	most	most	ADV
gsrj-12	25	30	promising	promising	ADJ
gsrj-12	25	31	target	target	NOUN
gsrj-12	25	32	for	for	ADP
gsrj-12	25	33	the	the	DET
gsrj-12	25	34	treatment	treatment	NOUN
gsrj-12	25	35	of	of	ADP
gsrj-12	25	36	refractory	refractory	NOUN
gsrj-12	25	37	epilepsy	epilepsy	NOUN
gsrj-12	25	38	.	.	PUNCT
gsrj-12	26	1	2	2	X
gsrj-12	26	2	.	.	X
gsrj-12	26	3	�	�	PROPN
gsrj-12	26	4	the	the	DET
gsrj-12	26	5	transporter	transporter	NOUN
gsrj-12	26	6	hypothesis	hypothesis	NOUN
gsrj-12	26	7	in	in	ADP
gsrj-12	26	8	refractory	refractory	NOUN
gsrj-12	26	9	�	�	PROPN
gsrj-12	26	10	epilepsy	epilepsy	VERB
gsrj-12	26	11	many	many	ADJ
gsrj-12	26	12	studies	study	NOUN
gsrj-12	26	13	have	have	AUX
gsrj-12	26	14	worked	work	VERB
gsrj-12	26	15	to	to	PART
gsrj-12	26	16	evaluate	evaluate	VERB
gsrj-12	26	17	various	various	ADJ
gsrj-12	26	18	theories	theory	NOUN
gsrj-12	26	19	regarding	regard	VERB
gsrj-12	26	20	the	the	DET
gsrj-12	26	21	potential	potential	ADJ
gsrj-12	26	22	mechanisms	mechanism	NOUN
gsrj-12	26	23	of	of	ADP
gsrj-12	26	24	pharmacoresistance	pharmacoresistance	NOUN
gsrj-12	26	25	in	in	ADP
gsrj-12	26	26	refractory	refractory	NOUN
gsrj-12	26	27	epilepsy	epilepsy	NOUN
gsrj-12	26	28	,	,	PUNCT
gsrj-12	26	29	although	although	SCONJ
gsrj-12	26	30	there	there	PRON
gsrj-12	26	31	is	be	VERB
gsrj-12	26	32	a	a	DET
gsrj-12	26	33	general	general	ADJ
gsrj-12	26	34	consensus	consensus	NOUN
gsrj-12	26	35	that	that	SCONJ
gsrj-12	26	36	protein	protein	NOUN
gsrj-12	26	37	transporters	transporter	NOUN
gsrj-12	26	38	have	have	VERB
gsrj-12	26	39	the	the	DET
gsrj-12	26	40	most	most	ADJ
gsrj-12	26	41	influence	influence	NOUN
gsrj-12	26	42	over	over	ADP
gsrj-12	26	43	refractoriness	refractoriness	NOUN
gsrj-12	26	44	.	.	PUNCT
gsrj-12	27	1	this	this	PRON
gsrj-12	27	2	is	be	AUX
gsrj-12	27	3	especially	especially	ADV
gsrj-12	27	4	noted	note	VERB
gsrj-12	27	5	in	in	ADP
gsrj-12	27	6	a	a	DET
gsrj-12	27	7	comprehensive	comprehensive	ADJ
gsrj-12	27	8	review	review	NOUN
gsrj-12	27	9	focused	focus	VERB
gsrj-12	27	10	on	on	ADP
gsrj-12	27	11	drug	drug	NOUN
gsrj-12	27	12	-	-	PUNCT
gsrj-12	27	13	resistant	resistant	ADJ
gsrj-12	27	14	epilepsy	epilepsy	NOUN
gsrj-12	27	15	that	that	PRON
gsrj-12	27	16	evaluated	evaluate	VERB
gsrj-12	27	17	a	a	DET
gsrj-12	27	18	wide	wide	ADJ
gsrj-12	27	19	variety	variety	NOUN
gsrj-12	27	20	of	of	ADP
gsrj-12	27	21	studies	study	NOUN
gsrj-12	27	22	on	on	ADP
gsrj-12	27	23	refractory	refractory	NOUN
gsrj-12	27	24	epilepsy	epilepsy	NOUN
gsrj-12	27	25	and	and	CCONJ
gsrj-12	27	26	summarized	summarize	VERB
gsrj-12	27	27	the	the	DET
gsrj-12	27	28	potential	potential	ADJ
gsrj-12	27	29	hypotheses	hypothesis	NOUN
gsrj-12	27	30	for	for	ADP
gsrj-12	27	31	mechanisms	mechanism	NOUN
gsrj-12	27	32	of	of	ADP
gsrj-12	27	33	pharmacoresistance.9	pharmacoresistance.9	PROPN
gsrj-12	27	34	tang	tang	X
gsrj-12	27	35	et	et	PROPN
gsrj-12	27	36	al	al	PROPN
gsrj-12	27	37	.	.	PROPN
gsrj-12	27	38	,	,	PUNCT
gsrj-12	27	39	2017	2017	NUM
gsrj-12	27	40	suggested	suggest	VERB
gsrj-12	27	41	that	that	SCONJ
gsrj-12	27	42	the	the	DET
gsrj-12	27	43	drug	drug	NOUN
gsrj-12	27	44	-	-	PUNCT
gsrj-12	27	45	resistance	resistance	NOUN
gsrj-12	27	46	of	of	ADP
gsrj-12	27	47	refractory	refractory	NOUN
gsrj-12	27	48	epilepsy	epilepsy	NOUN
gsrj-12	27	49	may	may	AUX
gsrj-12	27	50	come	come	VERB
gsrj-12	27	51	from	from	ADP
gsrj-12	27	52	seizure	seizure	VERB
gsrj-12	27	53	-	-	PUNCT
gsrj-12	27	54	induced	induce	VERB
gsrj-12	27	55	neural	neural	ADJ
gsrj-12	27	56	damage	damage	NOUN
gsrj-12	27	57	that	that	PRON
gsrj-12	27	58	prevents	prevent	VERB
gsrj-12	27	59	anti	anti	ADJ
gsrj-12	27	60	-	-	ADJ
gsrj-12	27	61	epilepsy	epilepsy	ADJ
gsrj-12	27	62	drugs	drug	NOUN
gsrj-12	27	63	from	from	ADP
gsrj-12	27	64	accessing	access	VERB
gsrj-12	27	65	their	their	PRON
gsrj-12	27	66	neuronal	neuronal	ADJ
gsrj-12	27	67	targets	target	NOUN
gsrj-12	27	68	.	.	PUNCT
gsrj-12	28	1	another	another	DET
gsrj-12	28	2	collection	collection	NOUN
gsrj-12	28	3	of	of	ADP
gsrj-12	28	4	studies	study	NOUN
gsrj-12	28	5	included	include	VERB
gsrj-12	28	6	in	in	ADP
gsrj-12	28	7	the	the	DET
gsrj-12	28	8	same	same	ADJ
gsrj-12	28	9	review	review	NOUN
gsrj-12	28	10	suggested	suggest	VERB
gsrj-12	28	11	that	that	SCONJ
gsrj-12	28	12	pharmacoresistance	pharmacoresistance	PROPN
gsrj-12	28	13	is	be	AUX
gsrj-12	28	14	inherent	inherent	ADJ
gsrj-12	28	15	to	to	ADP
gsrj-12	28	16	the	the	DET
gsrj-12	28	17	severity	severity	NOUN
gsrj-12	28	18	of	of	ADP
gsrj-12	28	19	epilepsy.8	epilepsy.8	PROPN
gsrj-12	28	20	while	while	SCONJ
gsrj-12	28	21	many	many	ADJ
gsrj-12	28	22	of	of	ADP
gsrj-12	28	23	these	these	DET
gsrj-12	28	24	hypotheses	hypothesis	NOUN
gsrj-12	28	25	are	be	AUX
gsrj-12	28	26	biologically	biologically	ADV
gsrj-12	28	27	plausible	plausible	ADJ
gsrj-12	28	28	,	,	PUNCT
gsrj-12	28	29	there	there	PRON
gsrj-12	28	30	is	be	VERB
gsrj-12	28	31	a	a	DET
gsrj-12	28	32	significant	significant	ADJ
gsrj-12	28	33	lack	lack	NOUN
gsrj-12	28	34	of	of	ADP
gsrj-12	28	35	evidence	evidence	NOUN
gsrj-12	28	36	,	,	PUNCT
gsrj-12	28	37	association	association	NOUN
gsrj-12	28	38	,	,	PUNCT
gsrj-12	28	39	consistency	consistency	NOUN
gsrj-12	28	40	,	,	PUNCT
gsrj-12	28	41	and	and	CCONJ
gsrj-12	28	42	specificity	specificity	NOUN
gsrj-12	28	43	in	in	ADP
gsrj-12	28	44	the	the	DET
gsrj-12	28	45	literature	literature	NOUN
gsrj-12	28	46	to	to	PART
gsrj-12	28	47	demonstrate	demonstrate	VERB
gsrj-12	28	48	their	their	PRON
gsrj-12	28	49	validity	validity	NOUN
gsrj-12	28	50	.	.	PUNCT
gsrj-12	29	1	however	however	ADV
gsrj-12	29	2	,	,	PUNCT
gsrj-12	29	3	one	one	NUM
gsrj-12	29	4	hypothesis	hypothesis	NOUN
gsrj-12	29	5	from	from	ADP
gsrj-12	29	6	the	the	DET
gsrj-12	29	7	review	review	NOUN
gsrj-12	29	8	stood	stand	VERB
gsrj-12	29	9	out	out	ADP
gsrj-12	29	10	as	as	ADP
gsrj-12	29	11	the	the	DET
gsrj-12	29	12	most	most	ADV
gsrj-12	29	13	promising	promising	ADJ
gsrj-12	29	14	mechanism	mechanism	NOUN
gsrj-12	29	15	for	for	ADP
gsrj-12	29	16	refractory	refractory	NOUN
gsrj-12	29	17	epilepsy	epilepsy	NOUN
gsrj-12	29	18	:	:	PUNCT
gsrj-12	29	19	the	the	DET
gsrj-12	29	20	transporter	transporter	NOUN
gsrj-12	29	21	hypothesis	hypothesis	NOUN
gsrj-12	29	22	.	.	PUNCT
gsrj-12	30	1	the	the	DET
gsrj-12	30	2	transporter	transporter	NOUN
gsrj-12	30	3	hypothesis	hypothesis	NOUN
gsrj-12	30	4	suggests	suggest	VERB
gsrj-12	30	5	that	that	SCONJ
gsrj-12	30	6	the	the	DET
gsrj-12	30	7	overexpression	overexpression	NOUN
gsrj-12	30	8	of	of	ADP
gsrj-12	30	9	efflux	efflux	NOUN
gsrj-12	30	10	transporter	transporter	NOUN
gsrj-12	30	11	proteins	protein	NOUN
gsrj-12	30	12	in	in	ADP
gsrj-12	30	13	the	the	DET
gsrj-12	30	14	brain	brain	NOUN
gsrj-12	30	15	tissue	tissue	NOUN
gsrj-12	30	16	of	of	ADP
gsrj-12	30	17	epileptic	epileptic	ADJ
gsrj-12	30	18	patients	patient	NOUN
gsrj-12	30	19	causes	cause	VERB
gsrj-12	30	20	drug	drug	NOUN
gsrj-12	30	21	resistance	resistance	NOUN
gsrj-12	30	22	by	by	ADP
gsrj-12	30	23	decreasing	decrease	VERB
gsrj-12	30	24	the	the	DET
gsrj-12	30	25	permeability	permeability	NOUN
gsrj-12	30	26	of	of	ADP
gsrj-12	30	27	the	the	DET
gsrj-12	30	28	blood	blood	NOUN
gsrj-12	30	29	brain	brain	NOUN
gsrj-12	30	30	barrier	barrier	NOUN
gsrj-12	30	31	for	for	ADP
gsrj-12	30	32	aeds.10	aeds.10	NOUN
gsrj-12	30	33	there	there	PRON
gsrj-12	30	34	are	be	VERB
gsrj-12	30	35	different	different	ADJ
gsrj-12	30	36	types	type	NOUN
gsrj-12	30	37	of	of	ADP
gsrj-12	30	38	protein	protein	NOUN
gsrj-12	30	39	transporters	transporter	NOUN
gsrj-12	30	40	that	that	PRON
gsrj-12	30	41	carry	carry	VERB
gsrj-12	30	42	out	out	ADP
gsrj-12	30	43	this	this	DET
gsrj-12	30	44	mechanism	mechanism	NOUN
gsrj-12	30	45	of	of	ADP
gsrj-12	30	46	pharmacoresistance	pharmacoresistance	NOUN
gsrj-12	30	47	:	:	PUNCT
gsrj-12	30	48	p	p	X
gsrj-12	30	49	-	-	PUNCT
gsrj-12	30	50	gps	gps	NOUN
gsrj-12	30	51	,	,	PUNCT
gsrj-12	30	52	mrps	mrps	PROPN
gsrj-12	30	53	,	,	PUNCT
gsrj-12	30	54	and	and	CCONJ
gsrj-12	30	55	brcs	brc	NOUN
gsrj-12	30	56	,	,	PUNCT
gsrj-12	30	57	which	which	PRON
gsrj-12	30	58	are	be	AUX
gsrj-12	30	59	all	all	PRON
gsrj-12	30	60	part	part	NOUN
gsrj-12	30	61	of	of	ADP
gsrj-12	30	62	the	the	DET
gsrj-12	30	63	abc	abc	PROPN
gsrj-12	30	64	transporter	transporter	NOUN
gsrj-12	30	65	family.7,9	family.7,9	PROPN
gsrj-12	30	66	out	out	ADP
gsrj-12	30	67	of	of	ADP
gsrj-12	30	68	these	these	DET
gsrj-12	30	69	transporters	transporter	NOUN
gsrj-12	30	70	,	,	PUNCT
gsrj-12	30	71	the	the	DET
gsrj-12	30	72	overexpression	overexpression	NOUN
gsrj-12	30	73	of	of	ADP
gsrj-12	30	74	p	p	NOUN
gsrj-12	30	75	-	-	PUNCT
gsrj-12	30	76	gp	gp	NOUN
gsrj-12	30	77	is	be	AUX
gsrj-12	30	78	most	most	ADV
gsrj-12	30	79	prominently	prominently	ADV
gsrj-12	30	80	associated	associate	VERB
gsrj-12	30	81	with	with	ADP
gsrj-12	30	82	pharmacoresistance	pharmacoresistance	PROPN
gsrj-12	30	83	,	,	PUNCT
gsrj-12	30	84	as	as	SCONJ
gsrj-12	30	85	increased	increase	VERB
gsrj-12	30	86	expression	expression	NOUN
gsrj-12	30	87	of	of	ADP
gsrj-12	30	88	p	p	NOUN
gsrj-12	30	89	-	-	PUNCT
gsrj-12	30	90	gp	gp	NOUN
gsrj-12	30	91	in	in	ADP
gsrj-12	30	92	the	the	DET
gsrj-12	30	93	brain	brain	NOUN
gsrj-12	30	94	tissue	tissue	NOUN
gsrj-12	30	95	of	of	ADP
gsrj-12	30	96	refractory	refractory	NOUN
gsrj-12	30	97	epilepsy	epilepsy	NOUN
gsrj-12	30	98	patients	patient	NOUN
gsrj-12	30	99	had	have	VERB
gsrj-12	30	100	a	a	DET
gsrj-12	30	101	low	low	ADJ
gsrj-12	30	102	aed	aed	NOUN
gsrj-12	30	103	response.9	response.9	NOUN
gsrj-12	30	104	the	the	DET
gsrj-12	30	105	overexpression	overexpression	NOUN
gsrj-12	30	106	of	of	ADP
gsrj-12	30	107	mrps	mrps	PROPN
gsrj-12	30	108	shows	show	VERB
gsrj-12	30	109	similar	similar	ADJ
gsrj-12	30	110	promise	promise	NOUN
gsrj-12	30	111	as	as	ADP
gsrj-12	30	112	a	a	DET
gsrj-12	30	113	potential	potential	ADJ
gsrj-12	30	114	mechanism	mechanism	NOUN
gsrj-12	30	115	of	of	ADP
gsrj-12	30	116	refractory	refractory	NOUN
gsrj-12	30	117	epilepsy	epilepsy	NOUN
gsrj-12	30	118	,	,	PUNCT
gsrj-12	30	119	but	but	CCONJ
gsrj-12	30	120	they	they	PRON
gsrj-12	30	121	have	have	AUX
gsrj-12	30	122	not	not	PART
gsrj-12	30	123	been	be	AUX
gsrj-12	30	124	extensively	extensively	ADV
gsrj-12	30	125	studied	study	VERB
gsrj-12	30	126	with	with	ADP
gsrj-12	30	127	controls	control	NOUN
gsrj-12	30	128	to	to	PART
gsrj-12	30	129	further	far	ADV
gsrj-12	30	130	prove	prove	VERB
gsrj-12	30	131	their	their	PRON
gsrj-12	30	132	association	association	NOUN
gsrj-12	30	133	.	.	PUNCT
gsrj-12	31	1	while	while	SCONJ
gsrj-12	31	2	bcrps	bcrps	NOUN
gsrj-12	31	3	perform	perform	VERB
gsrj-12	31	4	a	a	DET
gsrj-12	31	5	similar	similar	ADJ
gsrj-12	31	6	role	role	NOUN
gsrj-12	31	7	in	in	ADP
gsrj-12	31	8	pharmacoresistance	pharmacoresistance	PROPN
gsrj-12	31	9	,	,	PUNCT
gsrj-12	31	10	it	it	PRON
gsrj-12	31	11	has	have	AUX
gsrj-12	31	12	been	be	AUX
gsrj-12	31	13	suggested	suggest	VERB
gsrj-12	31	14	that	that	SCONJ
gsrj-12	31	15	these	these	DET
gsrj-12	31	16	transporters	transporter	NOUN
gsrj-12	31	17	have	have	VERB
gsrj-12	31	18	better	well	ADJ
gsrj-12	31	19	therapeutic	therapeutic	ADJ
gsrj-12	31	20	potential	potential	NOUN
gsrj-12	31	21	for	for	ADP
gsrj-12	31	22	cancer	cancer	NOUN
gsrj-12	31	23	rather	rather	ADV
gsrj-12	31	24	than	than	ADP
gsrj-12	31	25	refractory	refractory	NOUN
gsrj-12	31	26	epilepsy.9	epilepsy.9	NOUN
gsrj-12	31	27	ultimately	ultimately	ADV
gsrj-12	31	28	,	,	PUNCT
gsrj-12	31	29	based	base	VERB
gsrj-12	31	30	on	on	ADP
gsrj-12	31	31	the	the	DET
gsrj-12	31	32	current	current	ADJ
gsrj-12	31	33	findings	finding	NOUN
gsrj-12	31	34	and	and	CCONJ
gsrj-12	31	35	evidence	evidence	NOUN
gsrj-12	31	36	,	,	PUNCT
gsrj-12	31	37	it	it	PRON
gsrj-12	31	38	can	can	AUX
gsrj-12	31	39	be	be	AUX
gsrj-12	31	40	deduced	deduce	VERB
gsrj-12	31	41	that	that	SCONJ
gsrj-12	31	42	the	the	DET
gsrj-12	31	43	clearance	clearance	NOUN
gsrj-12	31	44	of	of	ADP
gsrj-12	31	45	aeds	aed	NOUN
gsrj-12	31	46	by	by	ADP
gsrj-12	31	47	p	p	NOUN
gsrj-12	31	48	-	-	PUNCT
gsrj-12	31	49	gps	gps	NOUN
gsrj-12	31	50	shows	show	VERB
gsrj-12	31	51	the	the	DET
gsrj-12	31	52	most	most	ADV
gsrj-12	31	53	promise	promise	NOUN
gsrj-12	31	54	as	as	ADP
gsrj-12	31	55	a	a	DET
gsrj-12	31	56	mechanism	mechanism	NOUN
gsrj-12	31	57	of	of	ADP
gsrj-12	31	58	refractory	refractory	NOUN
gsrj-12	31	59	epilepsy	epilepsy	NOUN
gsrj-12	31	60	.	.	PUNCT
gsrj-12	32	1	thus	thus	ADV
gsrj-12	32	2	,	,	PUNCT
gsrj-12	32	3	resources	resource	NOUN
gsrj-12	32	4	should	should	AUX
gsrj-12	32	5	be	be	AUX
gsrj-12	32	6	allocated	allocate	VERB
gsrj-12	32	7	towards	towards	ADP
gsrj-12	32	8	exploring	explore	VERB
gsrj-12	32	9	these	these	DET
gsrj-12	32	10	proteins	protein	NOUN
gsrj-12	32	11	and	and	CCONJ
gsrj-12	32	12	investigating	investigate	VERB
gsrj-12	32	13	them	they	PRON
gsrj-12	32	14	as	as	ADP
gsrj-12	32	15	a	a	DET
gsrj-12	32	16	target	target	NOUN
gsrj-12	32	17	for	for	ADP
gsrj-12	32	18	future	future	ADJ
gsrj-12	32	19	treatment	treatment	NOUN
gsrj-12	32	20	.	.	PUNCT
gsrj-12	33	1	an	an	DET
gsrj-12	33	2	earlier	early	ADJ
gsrj-12	33	3	review	review	NOUN
gsrj-12	33	4	from	from	ADP
gsrj-12	33	5	2011	2011	NUM
gsrj-12	33	6	,	,	PUNCT
gsrj-12	33	7	which	which	PRON
gsrj-12	33	8	elaborated	elaborate	VERB
gsrj-12	33	9	on	on	ADP
gsrj-12	33	10	each	each	DET
gsrj-12	33	11	type	type	NOUN
gsrj-12	33	12	of	of	ADP
gsrj-12	33	13	transporter	transporter	NOUN
gsrj-12	33	14	and	and	CCONJ
gsrj-12	33	15	their	their	PRON
gsrj-12	33	16	mechanisms	mechanism	NOUN
gsrj-12	33	17	at	at	ADP
gsrj-12	33	18	the	the	DET
gsrj-12	33	19	bbb	bbb	PROPN
gsrj-12	33	20	,	,	PUNCT
gsrj-12	33	21	detailed	detail	VERB
gsrj-12	33	22	the	the	DET
gsrj-12	33	23	inhibition	inhibition	NOUN
gsrj-12	33	24	of	of	ADP
gsrj-12	33	25	p	p	NOUN
gsrj-12	33	26	-	-	PUNCT
gsrj-12	33	27	gp	gp	NOUN
gsrj-12	33	28	expression	expression	NOUN
gsrj-12	33	29	as	as	ADP
gsrj-12	33	30	a	a	DET
gsrj-12	33	31	potential	potential	ADJ
gsrj-12	33	32	treatment	treatment	NOUN
gsrj-12	33	33	option.10	option.10	NOUN
gsrj-12	33	34	to	to	PART
gsrj-12	33	35	build	build	VERB
gsrj-12	33	36	upon	upon	SCONJ
gsrj-12	33	37	these	these	DET
gsrj-12	33	38	analyses	analysis	NOUN
gsrj-12	33	39	,	,	PUNCT
gsrj-12	33	40	this	this	DET
gsrj-12	33	41	review	review	NOUN
gsrj-12	33	42	focuses	focus	VERB
gsrj-12	33	43	on	on	ADP
gsrj-12	33	44	p	p	NOUN
gsrj-12	33	45	-	-	PUNCT
gsrj-12	33	46	gp	gp	NOUN
gsrj-12	33	47	overexpression	overexpression	NOUN
gsrj-12	33	48	,	,	PUNCT
gsrj-12	33	49	its	its	PRON
gsrj-12	33	50	role	role	NOUN
gsrj-12	33	51	in	in	ADP
gsrj-12	33	52	102	102	NUM
gsrj-12	33	53	georgetown	georgetown	PROPN
gsrj-12	33	54	scientific	scientific	PROPN
gsrj-12	33	55	research	research	NOUN
gsrj-12	33	56	journal	journal	PROPN
gsrj-12	33	57	https://doi.org/10.48091/uwyg8998	https://doi.org/10.48091/uwyg8998	PROPN
gsrj-12	33	58	refractory	refractory	PROPN
gsrj-12	33	59	epilepsy	epilepsy	PROPN
gsrj-12	33	60	,	,	PUNCT
gsrj-12	33	61	and	and	CCONJ
gsrj-12	33	62	potential	potential	ADJ
gsrj-12	33	63	treatments	treatment	NOUN
gsrj-12	33	64	that	that	PRON
gsrj-12	33	65	target	target	VERB
gsrj-12	33	66	these	these	DET
gsrj-12	33	67	mechanisms	mechanism	NOUN
gsrj-12	33	68	.	.	PUNCT
gsrj-12	34	1	3	3	X
gsrj-12	34	2	.	.	X
gsrj-12	34	3	the	the	DET
gsrj-12	34	4	overexpression	overexpression	NOUN
gsrj-12	34	5	and	and	CCONJ
gsrj-12	34	6	mechanisms	mechanism	NOUN
gsrj-12	34	7	of	of	ADP
gsrj-12	34	8	pglycoproteins	pglycoprotein	NOUN
gsrj-12	34	9	in	in	ADP
gsrj-12	34	10	refractory	refractory	NOUN
gsrj-12	34	11	epilepsy	epilepsy	NOUN
gsrj-12	34	12	as	as	SCONJ
gsrj-12	34	13	previously	previously	ADV
gsrj-12	34	14	mentioned	mention	VERB
gsrj-12	34	15	,	,	PUNCT
gsrj-12	34	16	current	current	ADJ
gsrj-12	34	17	data	datum	NOUN
gsrj-12	34	18	shows	show	VERB
gsrj-12	34	19	that	that	SCONJ
gsrj-12	34	20	about	about	ADV
gsrj-12	34	21	one	one	NUM
gsrj-12	34	22	-	-	PUNCT
gsrj-12	34	23	third	third	NOUN
gsrj-12	34	24	of	of	ADP
gsrj-12	34	25	epilepsy	epilepsy	ADJ
gsrj-12	34	26	patients	patient	NOUN
gsrj-12	34	27	do	do	AUX
gsrj-12	34	28	not	not	PART
gsrj-12	34	29	respond	respond	VERB
gsrj-12	34	30	to	to	ADP
gsrj-12	34	31	most	most	ADJ
gsrj-12	34	32	types	type	NOUN
gsrj-12	34	33	of	of	ADP
gsrj-12	34	34	aeds	aed	NOUN
gsrj-12	34	35	,	,	PUNCT
gsrj-12	34	36	and	and	CCONJ
gsrj-12	34	37	it	it	PRON
gsrj-12	34	38	has	have	AUX
gsrj-12	34	39	been	be	AUX
gsrj-12	34	40	hypothesized	hypothesize	VERB
gsrj-12	34	41	in	in	ADP
gsrj-12	34	42	recent	recent	ADJ
gsrj-12	34	43	years	year	NOUN
gsrj-12	34	44	that	that	SCONJ
gsrj-12	34	45	one	one	NUM
gsrj-12	34	46	potential	potential	ADJ
gsrj-12	34	47	mechanism	mechanism	NOUN
gsrj-12	34	48	for	for	ADP
gsrj-12	34	49	the	the	DET
gsrj-12	34	50	resistance	resistance	NOUN
gsrj-12	34	51	to	to	ADP
gsrj-12	34	52	aeds	aed	NOUN
gsrj-12	34	53	is	be	AUX
gsrj-12	34	54	the	the	DET
gsrj-12	34	55	overexpression	overexpression	NOUN
gsrj-12	34	56	of	of	ADP
gsrj-12	34	57	p	p	NOUN
gsrj-12	34	58	-	-	PUNCT
gsrj-12	34	59	gp	gp	NOUN
gsrj-12	34	60	in	in	ADP
gsrj-12	34	61	the	the	DET
gsrj-12	34	62	blood	blood	NOUN
gsrj-12	34	63	-	-	PUNCT
gsrj-12	34	64	brain	brain	NOUN
gsrj-12	34	65	barrier	barrier	NOUN
gsrj-12	34	66	(	(	PUNCT
gsrj-12	34	67	bbb).11	bbb).11	PROPN
gsrj-12	34	68	as	as	SCONJ
gsrj-12	34	69	abc	abc	PROPN
gsrj-12	34	70	transporters	transporter	NOUN
gsrj-12	34	71	,	,	PUNCT
gsrj-12	34	72	p	p	X
gsrj-12	34	73	-	-	PUNCT
gsrj-12	34	74	gps	gps	NOUN
gsrj-12	34	75	use	use	NOUN
gsrj-12	34	76	atp	atp	NOUN
gsrj-12	34	77	hydrolysis	hydrolysis	NOUN
gsrj-12	34	78	to	to	PART
gsrj-12	34	79	allow	allow	VERB
gsrj-12	34	80	for	for	ADP
gsrj-12	34	81	efflux	efflux	NOUN
gsrj-12	34	82	of	of	ADP
gsrj-12	34	83	molecules	molecule	NOUN
gsrj-12	34	84	using	use	VERB
gsrj-12	34	85	the	the	DET
gsrj-12	34	86	aforementioned	aforementioned	ADJ
gsrj-12	34	87	alternate	alternate	ADJ
gsrj-12	34	88	access	access	NOUN
gsrj-12	34	89	mechanism.8,12	mechanism.8,12	VERB
gsrj-12	34	90	more	more	ADV
gsrj-12	34	91	specifically	specifically	ADV
gsrj-12	34	92	,	,	PUNCT
gsrj-12	34	93	p	p	X
gsrj-12	34	94	-	-	PUNCT
gsrj-12	34	95	gps	gps	PROPN
gsrj-12	34	96	are	be	AUX
gsrj-12	34	97	exporters	exporter	NOUN
gsrj-12	34	98	,	,	PUNCT
gsrj-12	34	99	so	so	SCONJ
gsrj-12	34	100	they	they	PRON
gsrj-12	34	101	actively	actively	ADV
gsrj-12	34	102	work	work	VERB
gsrj-12	34	103	towards	towards	ADP
gsrj-12	34	104	moving	move	VERB
gsrj-12	34	105	molecules	molecule	NOUN
gsrj-12	34	106	outside	outside	ADV
gsrj-12	34	107	of	of	ADP
gsrj-12	34	108	the	the	DET
gsrj-12	34	109	cell	cell	NOUN
gsrj-12	34	110	rather	rather	ADV
gsrj-12	34	111	than	than	ADP
gsrj-12	34	112	inside	inside	ADV
gsrj-12	34	113	,	,	PUNCT
gsrj-12	34	114	so	so	SCONJ
gsrj-12	34	115	it	it	PRON
gsrj-12	34	116	is	be	AUX
gsrj-12	34	117	clear	clear	ADJ
gsrj-12	34	118	that	that	SCONJ
gsrj-12	34	119	the	the	DET
gsrj-12	34	120	overexpression	overexpression	NOUN
gsrj-12	34	121	of	of	ADP
gsrj-12	34	122	these	these	DET
gsrj-12	34	123	exporters	exporter	NOUN
gsrj-12	34	124	are	be	AUX
gsrj-12	34	125	bound	bind	VERB
gsrj-12	34	126	to	to	PART
gsrj-12	34	127	lead	lead	VERB
gsrj-12	34	128	to	to	ADP
gsrj-12	34	129	decreased	decrease	VERB
gsrj-12	34	130	aed	aed	NOUN
gsrj-12	34	131	concentration.8	concentration.8	PROPN
gsrj-12	34	132	these	these	DET
gsrj-12	34	133	protein	protein	NOUN
gsrj-12	34	134	transporters	transporter	NOUN
gsrj-12	34	135	can	can	AUX
gsrj-12	34	136	exist	exist	VERB
gsrj-12	34	137	in	in	ADP
gsrj-12	34	138	large	large	ADJ
gsrj-12	34	139	numbers	number	NOUN
gsrj-12	34	140	in	in	ADP
gsrj-12	34	141	a	a	DET
gsrj-12	34	142	variety	variety	NOUN
gsrj-12	34	143	of	of	ADP
gsrj-12	34	144	locations	location	NOUN
gsrj-12	34	145	in	in	ADP
gsrj-12	34	146	the	the	DET
gsrj-12	34	147	body	body	NOUN
gsrj-12	34	148	such	such	ADJ
gsrj-12	34	149	as	as	ADP
gsrj-12	34	150	the	the	DET
gsrj-12	34	151	intestines	intestine	NOUN
gsrj-12	34	152	,	,	PUNCT
gsrj-12	34	153	liver	liver	NOUN
gsrj-12	34	154	,	,	PUNCT
gsrj-12	34	155	kidneys	kidney	NOUN
gsrj-12	34	156	,	,	PUNCT
gsrj-12	34	157	and	and	CCONJ
gsrj-12	34	158	the	the	DET
gsrj-12	34	159	bbb	bbb	PROPN
gsrj-12	34	160	.	.	PUNCT
gsrj-12	35	1	the	the	DET
gsrj-12	35	2	protein	protein	NOUN
gsrj-12	35	3	is	be	AUX
gsrj-12	35	4	likely	likely	ADV
gsrj-12	35	5	expressed	express	VERB
gsrj-12	35	6	in	in	ADP
gsrj-12	35	7	these	these	DET
gsrj-12	35	8	organs	organ	NOUN
gsrj-12	35	9	to	to	PART
gsrj-12	35	10	serve	serve	VERB
gsrj-12	35	11	as	as	ADP
gsrj-12	35	12	a	a	DET
gsrj-12	35	13	defense	defense	NOUN
gsrj-12	35	14	mechanism	mechanism	NOUN
gsrj-12	35	15	against	against	ADP
gsrj-12	35	16	foreign	foreign	ADJ
gsrj-12	35	17	substances.12,13	substances.12,13	NOUN
gsrj-12	35	18	for	for	ADP
gsrj-12	35	19	example	example	NOUN
gsrj-12	35	20	,	,	PUNCT
gsrj-12	35	21	this	this	DET
gsrj-12	35	22	protein	protein	NOUN
gsrj-12	35	23	exists	exist	VERB
gsrj-12	35	24	in	in	ADP
gsrj-12	35	25	the	the	DET
gsrj-12	35	26	intestinal	intestinal	ADJ
gsrj-12	35	27	epithelium	epithelium	NOUN
gsrj-12	35	28	,	,	PUNCT
gsrj-12	35	29	where	where	SCONJ
gsrj-12	35	30	it	it	PRON
gsrj-12	35	31	pumps	pump	VERB
gsrj-12	35	32	toxins	toxin	NOUN
gsrj-12	35	33	back	back	ADV
gsrj-12	35	34	into	into	ADP
gsrj-12	35	35	the	the	DET
gsrj-12	35	36	intestinal	intestinal	ADJ
gsrj-12	35	37	lumen	luman	NOUN
gsrj-12	35	38	.	.	PUNCT
gsrj-12	36	1	p	p	X
gsrj-12	36	2	-	-	PUNCT
gsrj-12	36	3	gps	gps	PROPN
gsrj-12	36	4	can	can	AUX
gsrj-12	36	5	play	play	VERB
gsrj-12	36	6	an	an	DET
gsrj-12	36	7	integral	integral	ADJ
gsrj-12	36	8	role	role	NOUN
gsrj-12	36	9	in	in	ADP
gsrj-12	36	10	the	the	DET
gsrj-12	36	11	effluxion	effluxion	NOUN
gsrj-12	36	12	,	,	PUNCT
gsrj-12	36	13	or	or	CCONJ
gsrj-12	36	14	clearance	clearance	NOUN
gsrj-12	36	15	,	,	PUNCT
gsrj-12	36	16	of	of	ADP
gsrj-12	36	17	chronic	chronic	ADJ
gsrj-12	36	18	disease	disease	NOUN
gsrj-12	36	19	drugs	drug	NOUN
gsrj-12	36	20	.	.	PUNCT
gsrj-12	37	1	specifically	specifically	ADV
gsrj-12	37	2	,	,	PUNCT
gsrj-12	37	3	p	p	NOUN
gsrj-12	37	4	-	-	PUNCT
gsrj-12	37	5	gp	gp	NOUN
gsrj-12	37	6	is	be	AUX
gsrj-12	37	7	a	a	DET
gsrj-12	37	8	key	key	ADJ
gsrj-12	37	9	efflux	efflux	NOUN
gsrj-12	37	10	protein	protein	NOUN
gsrj-12	37	11	of	of	ADP
gsrj-12	37	12	the	the	DET
gsrj-12	37	13	bbb	bbb	NOUN
gsrj-12	37	14	that	that	PRON
gsrj-12	37	15	actively	actively	ADV
gsrj-12	37	16	transports	transport	VERB
gsrj-12	37	17	large	large	ADJ
gsrj-12	37	18	amounts	amount	NOUN
gsrj-12	37	19	of	of	ADP
gsrj-12	37	20	lipophilic	lipophilic	ADJ
gsrj-12	37	21	drugs	drug	NOUN
gsrj-12	37	22	,	,	PUNCT
gsrj-12	37	23	including	include	VERB
gsrj-12	37	24	aeds	aed	NOUN
gsrj-12	37	25	,	,	PUNCT
gsrj-12	37	26	out	out	ADP
gsrj-12	37	27	of	of	ADP
gsrj-12	37	28	the	the	DET
gsrj-12	37	29	bbb	bbb	NOUN
gsrj-12	37	30	membrane	membrane	NOUN
gsrj-12	37	31	and	and	CCONJ
gsrj-12	37	32	back	back	ADV
gsrj-12	37	33	into	into	ADP
gsrj-12	37	34	the	the	DET
gsrj-12	37	35	bloodstream	bloodstream	NOUN
gsrj-12	37	36	,	,	PUNCT
gsrj-12	37	37	therefore	therefore	ADV
gsrj-12	37	38	resulting	result	VERB
gsrj-12	37	39	in	in	ADP
gsrj-12	37	40	pharmacoresistance	pharmacoresistance	NOUN
gsrj-12	37	41	to	to	ADP
gsrj-12	37	42	therapeutic	therapeutic	ADJ
gsrj-12	37	43	medications	medication	NOUN
gsrj-12	37	44	intended	intend	VERB
gsrj-12	37	45	to	to	PART
gsrj-12	37	46	target	target	VERB
gsrj-12	37	47	the	the	DET
gsrj-12	37	48	brain.11,12	brain.11,12	NOUN
gsrj-12	37	49	there	there	ADV
gsrj-12	37	50	have	have	AUX
gsrj-12	37	51	been	be	AUX
gsrj-12	37	52	many	many	ADJ
gsrj-12	37	53	clinical	clinical	ADJ
gsrj-12	37	54	studies	study	NOUN
gsrj-12	37	55	that	that	PRON
gsrj-12	37	56	demonstrated	demonstrate	VERB
gsrj-12	37	57	how	how	SCONJ
gsrj-12	37	58	the	the	DET
gsrj-12	37	59	decreased	decreased	ADJ
gsrj-12	37	60	concentration	concentration	NOUN
gsrj-12	37	61	of	of	ADP
gsrj-12	37	62	aeds	aed	NOUN
gsrj-12	37	63	can	can	AUX
gsrj-12	37	64	result	result	VERB
gsrj-12	37	65	from	from	ADP
gsrj-12	37	66	p	p	NOUN
gsrj-12	37	67	-	-	PUNCT
gsrj-12	37	68	gp	gp	NOUN
gsrj-12	37	69	overexpression	overexpression	NOUN
gsrj-12	37	70	.	.	PUNCT
gsrj-12	38	1	in	in	ADP
gsrj-12	38	2	one	one	NUM
gsrj-12	38	3	case	case	NOUN
gsrj-12	38	4	study	study	NOUN
gsrj-12	38	5	,	,	PUNCT
gsrj-12	38	6	surgery	surgery	NOUN
gsrj-12	38	7	was	be	AUX
gsrj-12	38	8	conducted	conduct	VERB
gsrj-12	38	9	on	on	ADP
gsrj-12	38	10	a	a	DET
gsrj-12	38	11	patient	patient	NOUN
gsrj-12	38	12	with	with	ADP
gsrj-12	38	13	partial	partial	ADJ
gsrj-12	38	14	refractory	refractory	NOUN
gsrj-12	38	15	epilepsy	epilepsy	NOUN
gsrj-12	38	16	to	to	PART
gsrj-12	38	17	alleviate	alleviate	VERB
gsrj-12	38	18	epileptic	epileptic	ADJ
gsrj-12	38	19	symptoms	symptom	NOUN
gsrj-12	38	20	.	.	PUNCT
gsrj-12	39	1	prior	prior	ADV
gsrj-12	39	2	to	to	ADP
gsrj-12	39	3	this	this	DET
gsrj-12	39	4	study	study	NOUN
gsrj-12	39	5	,	,	PUNCT
gsrj-12	39	6	the	the	DET
gsrj-12	39	7	patient	patient	NOUN
gsrj-12	39	8	was	be	AUX
gsrj-12	39	9	treated	treat	VERB
gsrj-12	39	10	with	with	ADP
gsrj-12	39	11	many	many	ADJ
gsrj-12	39	12	different	different	ADJ
gsrj-12	39	13	aeds	aed	NOUN
gsrj-12	39	14	and	and	CCONJ
gsrj-12	39	15	doses	dose	NOUN
gsrj-12	39	16	with	with	ADP
gsrj-12	39	17	no	no	DET
gsrj-12	39	18	measured	measured	ADJ
gsrj-12	39	19	success	success	NOUN
gsrj-12	39	20	in	in	ADP
gsrj-12	39	21	controlling	control	VERB
gsrj-12	39	22	the	the	DET
gsrj-12	39	23	patient	patient	NOUN
gsrj-12	39	24	s	s	PART
gsrj-12	39	25	symptoms.5	symptoms.5	PROPN
gsrj-12	39	26	prior	prior	ADV
gsrj-12	39	27	to	to	ADP
gsrj-12	39	28	surgery	surgery	NOUN
gsrj-12	39	29	,	,	PUNCT
gsrj-12	39	30	researchers	researcher	NOUN
gsrj-12	39	31	collected	collect	VERB
gsrj-12	39	32	and	and	CCONJ
gsrj-12	39	33	measured	measure	VERB
gsrj-12	39	34	aed	aed	NOUN
gsrj-12	39	35	blood	blood	NOUN
gsrj-12	39	36	levels	level	NOUN
gsrj-12	39	37	in	in	ADP
gsrj-12	39	38	the	the	DET
gsrj-12	39	39	patient	patient	NOUN
gsrj-12	39	40	's	's	PART
gsrj-12	39	41	serum	serum	NOUN
gsrj-12	39	42	samples	sample	NOUN
gsrj-12	39	43	for	for	ADP
gsrj-12	39	44	25	25	NUM
gsrj-12	39	45	days	day	NOUN
gsrj-12	39	46	before	before	SCONJ
gsrj-12	39	47	each	each	DET
gsrj-12	39	48	administered	administer	VERB
gsrj-12	39	49	dose	dose	NOUN
gsrj-12	39	50	of	of	ADP
gsrj-12	39	51	aeds	aed	NOUN
gsrj-12	39	52	to	to	PART
gsrj-12	39	53	observe	observe	VERB
gsrj-12	39	54	the	the	DET
gsrj-12	39	55	patient	patient	NOUN
gsrj-12	39	56	s	s	PART
gsrj-12	39	57	aed	aed	NOUN
gsrj-12	39	58	concentration	concentration	NOUN
gsrj-12	39	59	in	in	ADP
gsrj-12	39	60	the	the	DET
gsrj-12	39	61	blood	blood	NOUN
gsrj-12	39	62	.	.	PUNCT
gsrj-12	40	1	it	it	PRON
gsrj-12	40	2	was	be	AUX
gsrj-12	40	3	found	find	VERB
gsrj-12	40	4	that	that	SCONJ
gsrj-12	40	5	all	all	DET
gsrj-12	40	6	types	type	NOUN
gsrj-12	40	7	of	of	ADP
gsrj-12	40	8	the	the	DET
gsrj-12	40	9	aeds	aed	NOUN
gsrj-12	40	10	that	that	PRON
gsrj-12	40	11	the	the	DET
gsrj-12	40	12	patient	patient	NOUN
gsrj-12	40	13	received	receive	VERB
gsrj-12	40	14	were	be	AUX
gsrj-12	40	15	observed	observe	VERB
gsrj-12	40	16	in	in	ADP
gsrj-12	40	17	subtherapeutic	subtherapeutic	ADJ
gsrj-12	40	18	levels	level	NOUN
gsrj-12	40	19	in	in	ADP
gsrj-12	40	20	a	a	DET
gsrj-12	40	21	significant	significant	ADJ
gsrj-12	40	22	portion	portion	NOUN
gsrj-12	40	23	of	of	ADP
gsrj-12	40	24	the	the	DET
gsrj-12	40	25	serum	serum	NOUN
gsrj-12	40	26	samples	sample	NOUN
gsrj-12	40	27	collected	collect	VERB
gsrj-12	40	28	.	.	PUNCT
gsrj-12	41	1	this	this	PRON
gsrj-12	41	2	indicates	indicate	VERB
gsrj-12	41	3	very	very	ADV
gsrj-12	41	4	low	low	ADJ
gsrj-12	41	5	aed	aed	NOUN
gsrj-12	41	6	concentration	concentration	NOUN
gsrj-12	41	7	throughout	throughout	ADP
gsrj-12	41	8	the	the	DET
gsrj-12	41	9	blood	blood	NOUN
gsrj-12	41	10	.	.	PUNCT
gsrj-12	42	1	during	during	ADP
gsrj-12	42	2	the	the	DET
gsrj-12	42	3	surgery	surgery	NOUN
gsrj-12	42	4	,	,	PUNCT
gsrj-12	42	5	some	some	DET
gsrj-12	42	6	samples	sample	NOUN
gsrj-12	42	7	of	of	ADP
gsrj-12	42	8	brain	brain	NOUN
gsrj-12	42	9	tissue	tissue	NOUN
gsrj-12	42	10	were	be	AUX
gsrj-12	42	11	collected	collect	VERB
gsrj-12	42	12	for	for	ADP
gsrj-12	42	13	immunohistochemical	immunohistochemical	ADJ
gsrj-12	42	14	analysis	analysis	NOUN
gsrj-12	42	15	to	to	PART
gsrj-12	42	16	determine	determine	VERB
gsrj-12	42	17	the	the	DET
gsrj-12	42	18	cause	cause	NOUN
gsrj-12	42	19	of	of	ADP
gsrj-12	42	20	these	these	DET
gsrj-12	42	21	subtherapeutic	subtherapeutic	ADJ
gsrj-12	42	22	aed	aed	NOUN
gsrj-12	42	23	levels	level	NOUN
gsrj-12	42	24	in	in	ADP
gsrj-12	42	25	the	the	DET
gsrj-12	42	26	blood	blood	NOUN
gsrj-12	42	27	.	.	PUNCT
gsrj-12	43	1	from	from	ADP
gsrj-12	43	2	this	this	DET
gsrj-12	43	3	analysis	analysis	NOUN
gsrj-12	43	4	,	,	PUNCT
gsrj-12	43	5	it	it	PRON
gsrj-12	43	6	was	be	AUX
gsrj-12	43	7	found	find	VERB
gsrj-12	43	8	that	that	SCONJ
gsrj-12	43	9	the	the	DET
gsrj-12	43	10	patient	patient	NOUN
gsrj-12	43	11	had	have	VERB
gsrj-12	43	12	high	high	ADJ
gsrj-12	43	13	brain	brain	NOUN
gsrj-12	43	14	expression	expression	NOUN
gsrj-12	43	15	of	of	ADP
gsrj-12	43	16	pgps	pgps	NOUN
gsrj-12	43	17	in	in	ADP
gsrj-12	43	18	not	not	PART
gsrj-12	43	19	only	only	ADV
gsrj-12	43	20	endothelial	endothelial	ADJ
gsrj-12	43	21	cells	cell	NOUN
gsrj-12	43	22	of	of	ADP
gsrj-12	43	23	the	the	DET
gsrj-12	43	24	bbb	bbb	NOUN
gsrj-12	43	25	but	but	CCONJ
gsrj-12	43	26	also	also	ADV
gsrj-12	43	27	in	in	ADP
gsrj-12	43	28	astrocytes	astrocyte	NOUN
gsrj-12	43	29	and	and	CCONJ
gsrj-12	43	30	neurons	neuron	NOUN
gsrj-12	43	31	.	.	PUNCT
gsrj-12	44	1	this	this	DET
gsrj-12	44	2	overexpression	overexpression	NOUN
gsrj-12	44	3	of	of	ADP
gsrj-12	44	4	p	p	NOUN
gsrj-12	44	5	-	-	PUNCT
gsrj-12	44	6	gps	gps	NOUN
gsrj-12	44	7	in	in	ADP
gsrj-12	44	8	regions	region	NOUN
gsrj-12	44	9	where	where	SCONJ
gsrj-12	44	10	drug	drug	NOUN
gsrj-12	44	11	elimination	elimination	NOUN
gsrj-12	44	12	actively	actively	ADV
gsrj-12	44	13	takes	take	VERB
gsrj-12	44	14	place	place	NOUN
gsrj-12	44	15	suggests	suggest	VERB
gsrj-12	44	16	that	that	SCONJ
gsrj-12	44	17	the	the	DET
gsrj-12	44	18	protein	protein	NOUN
gsrj-12	44	19	plays	play	VERB
gsrj-12	44	20	an	an	DET
gsrj-12	44	21	integral	integral	ADJ
gsrj-12	44	22	role	role	NOUN
gsrj-12	44	23	in	in	ADP
gsrj-12	44	24	the	the	DET
gsrj-12	44	25	efflux	efflux	NOUN
gsrj-12	44	26	and	and	CCONJ
gsrj-12	44	27	clearance	clearance	NOUN
gsrj-12	44	28	of	of	ADP
gsrj-12	44	29	aeds	aed	NOUN
gsrj-12	44	30	from	from	ADP
gsrj-12	44	31	the	the	DET
gsrj-12	44	32	brain	brain	NOUN
gsrj-12	44	33	.	.	PUNCT
gsrj-12	45	1	5	5	NUM
gsrj-12	45	2	this	this	DET
gsrj-12	45	3	study	study	NOUN
gsrj-12	45	4	is	be	AUX
gsrj-12	45	5	consistent	consistent	ADJ
gsrj-12	45	6	with	with	ADP
gsrj-12	45	7	other	other	ADJ
gsrj-12	45	8	case	case	NOUN
gsrj-12	45	9	studies	study	NOUN
gsrj-12	45	10	on	on	ADP
gsrj-12	45	11	patients	patient	NOUN
gsrj-12	45	12	with	with	ADP
gsrj-12	45	13	refractory	refractory	NOUN
gsrj-12	45	14	epilepsy	epilepsy	NOUN
gsrj-12	45	15	.	.	PUNCT
gsrj-12	46	1	in	in	ADP
gsrj-12	46	2	a	a	DET
gsrj-12	46	3	rat	rat	NOUN
gsrj-12	46	4	model	model	NOUN
gsrj-12	46	5	of	of	ADP
gsrj-12	46	6	epilepsy	epilepsy	PROPN
gsrj-12	46	7	,	,	PUNCT
gsrj-12	46	8	pgp	pgp	NOUN
gsrj-12	46	9	overexpression	overexpression	NOUN
gsrj-12	46	10	was	be	AUX
gsrj-12	46	11	assessed	assess	VERB
gsrj-12	46	12	following	follow	VERB
gsrj-12	46	13	the	the	DET
gsrj-12	46	14	administration	administration	NOUN
gsrj-12	46	15	of	of	ADP
gsrj-12	46	16	an	an	DET
gsrj-12	46	17	anti	anti	ADJ
gsrj-12	46	18	-	-	ADJ
gsrj-12	46	19	seizure	seizure	ADJ
gsrj-12	46	20	medication	medication	NOUN
gsrj-12	46	21	,	,	PUNCT
gsrj-12	46	22	phenobarbital	phenobarbital	ADJ
gsrj-12	46	23	.	.	PUNCT
gsrj-12	47	1	immunohistochemical	immunohistochemical	ADJ
gsrj-12	47	2	analysis	analysis	NOUN
gsrj-12	47	3	showed	show	VERB
gsrj-12	47	4	a	a	DET
gsrj-12	47	5	striking	striking	ADJ
gsrj-12	47	6	overexpression	overexpression	NOUN
gsrj-12	47	7	of	of	ADP
gsrj-12	47	8	p	p	NOUN
gsrj-12	47	9	-	-	PUNCT
gsrj-12	47	10	gp	gp	NOUN
gsrj-12	47	11	in	in	ADP
gsrj-12	47	12	the	the	DET
gsrj-12	47	13	limbic	limbic	ADJ
gsrj-12	47	14	brain	brain	NOUN
gsrj-12	47	15	regions	region	NOUN
gsrj-12	47	16	of	of	ADP
gsrj-12	47	17	the	the	DET
gsrj-12	47	18	rats	rat	NOUN
gsrj-12	47	19	that	that	PRON
gsrj-12	47	20	did	do	AUX
gsrj-12	47	21	not	not	PART
gsrj-12	47	22	respond	respond	VERB
gsrj-12	47	23	to	to	ADP
gsrj-12	47	24	the	the	DET
gsrj-12	47	25	medication.13	medication.13	PROPN
gsrj-12	47	26	in	in	ADP
gsrj-12	47	27	particular	particular	ADJ
gsrj-12	47	28	,	,	PUNCT
gsrj-12	47	29	overexpression	overexpression	NOUN
gsrj-12	47	30	of	of	ADP
gsrj-12	47	31	p	p	NOUN
gsrj-12	47	32	-	-	PUNCT
gsrj-12	47	33	gp	gp	NOUN
gsrj-12	47	34	could	could	AUX
gsrj-12	47	35	be	be	AUX
gsrj-12	47	36	narrowed	narrow	VERB
gsrj-12	47	37	down	down	ADP
gsrj-12	47	38	to	to	ADP
gsrj-12	47	39	the	the	DET
gsrj-12	47	40	brain	brain	NOUN
gsrj-12	47	41	capillary	capillary	ADJ
gsrj-12	47	42	endothelial	endothelial	ADJ
gsrj-12	47	43	cells	cell	NOUN
gsrj-12	47	44	of	of	ADP
gsrj-12	47	45	the	the	DET
gsrj-12	47	46	bbb.13	bbb.13	NOUN
gsrj-12	47	47	these	these	DET
gsrj-12	47	48	findings	finding	NOUN
gsrj-12	47	49	were	be	AUX
gsrj-12	47	50	consistent	consistent	ADJ
gsrj-12	47	51	with	with	ADP
gsrj-12	47	52	the	the	DET
gsrj-12	47	53	case	case	NOUN
gsrj-12	47	54	study	study	NOUN
gsrj-12	47	55	mentioned	mention	VERB
gsrj-12	47	56	above	above	ADV
gsrj-12	47	57	,	,	PUNCT
gsrj-12	47	58	suggesting	suggest	VERB
gsrj-12	47	59	an	an	DET
gsrj-12	47	60	association	association	NOUN
gsrj-12	47	61	between	between	ADP
gsrj-12	47	62	p	p	NOUN
gsrj-12	47	63	-	-	PUNCT
gsrj-12	47	64	gp	gp	NOUN
gsrj-12	47	65	overexpression	overexpression	NOUN
gsrj-12	47	66	and	and	CCONJ
gsrj-12	47	67	aed	aed	NOUN
gsrj-12	47	68	response	response	NOUN
gsrj-12	47	69	.	.	PUNCT
gsrj-12	48	1	other	other	ADJ
gsrj-12	48	2	studies	study	NOUN
gsrj-12	48	3	on	on	ADP
gsrj-12	48	4	bcrps	bcrps	NOUN
gsrj-12	48	5	and	and	CCONJ
gsrj-12	48	6	mrps	mrps	PROPN
gsrj-12	48	7	have	have	AUX
gsrj-12	48	8	not	not	PART
gsrj-12	48	9	been	be	AUX
gsrj-12	48	10	able	able	ADJ
gsrj-12	48	11	to	to	PART
gsrj-12	48	12	fully	fully	ADV
gsrj-12	48	13	conclude	conclude	VERB
gsrj-12	48	14	these	these	DET
gsrj-12	48	15	same	same	ADJ
gsrj-12	48	16	associations	association	NOUN
gsrj-12	48	17	with	with	ADP
gsrj-12	48	18	the	the	DET
gsrj-12	48	19	aed	aed	NOUN
gsrj-12	48	20	response	response	NOUN
gsrj-12	48	21	,	,	PUNCT
gsrj-12	48	22	suggesting	suggest	VERB
gsrj-12	48	23	that	that	SCONJ
gsrj-12	48	24	p	p	PROPN
gsrj-12	48	25	-	-	PUNCT
gsrj-12	48	26	gps	gps	PROPN
gsrj-12	48	27	are	be	AUX
gsrj-12	48	28	the	the	DET
gsrj-12	48	29	most	most	ADV
gsrj-12	48	30	promising	promising	ADJ
gsrj-12	48	31	candidates	candidate	NOUN
gsrj-12	48	32	for	for	ADP
gsrj-12	48	33	a	a	DET
gsrj-12	48	34	therapeutic	therapeutic	ADJ
gsrj-12	48	35	approach	approach	NOUN
gsrj-12	48	36	.	.	PUNCT
gsrj-12	49	1	other	other	ADJ
gsrj-12	49	2	experiments	experiment	NOUN
gsrj-12	49	3	focused	focus	VERB
gsrj-12	49	4	on	on	ADP
gsrj-12	49	5	looking	look	VERB
gsrj-12	49	6	at	at	ADP
gsrj-12	49	7	the	the	DET
gsrj-12	49	8	specific	specific	ADJ
gsrj-12	49	9	mechanism	mechanism	NOUN
gsrj-12	49	10	of	of	ADP
gsrj-12	49	11	p	p	NOUN
gsrj-12	49	12	-	-	PUNCT
gsrj-12	49	13	gps	gps	NOUN
gsrj-12	49	14	with	with	ADP
gsrj-12	49	15	specific	specific	ADJ
gsrj-12	49	16	substrates	substrate	NOUN
gsrj-12	49	17	.	.	PUNCT
gsrj-12	50	1	for	for	ADP
gsrj-12	50	2	example	example	NOUN
gsrj-12	50	3	,	,	PUNCT
gsrj-12	50	4	one	one	NUM
gsrj-12	50	5	study	study	NOUN
gsrj-12	50	6	conducted	conduct	VERB
gsrj-12	50	7	the	the	DET
gsrj-12	50	8	brain	brain	NOUN
gsrj-12	50	9	-	-	PUNCT
gsrj-12	50	10	to	to	ADP
gsrj-12	50	11	-	-	PUNCT
gsrj-12	50	12	plasma	plasma	NOUN
gsrj-12	50	13	difference	difference	NOUN
gsrj-12	50	14	of	of	ADP
gsrj-12	50	15	10	10	NUM
gsrj-12	50	16	-	-	PUNCT
gsrj-12	50	17	ohcbz	ohcbz	NOUN
gsrj-12	50	18	,	,	PUNCT
gsrj-12	50	19	an	an	DET
gsrj-12	50	20	active	active	ADJ
gsrj-12	50	21	metabolite	metabolite	NOUN
gsrj-12	50	22	,	,	PUNCT
gsrj-12	50	23	in	in	ADP
gsrj-12	50	24	refractory	refractory	NOUN
gsrj-12	50	25	epilepsy	epilepsy	NOUN
gsrj-12	50	26	patients	patient	NOUN
gsrj-12	50	27	who	who	PRON
gsrj-12	50	28	did	do	AUX
gsrj-12	50	29	not	not	PART
gsrj-12	50	30	respond	respond	VERB
gsrj-12	50	31	to	to	ADP
gsrj-12	50	32	the	the	DET
gsrj-12	50	33	aed	aed	NOUN
gsrj-12	50	34	treatment	treatment	NOUN
gsrj-12	50	35	oxcarbazepine.14	oxcarbazepine.14	PROPN
gsrj-12	50	36	in	in	ADP
gsrj-12	50	37	this	this	DET
gsrj-12	50	38	study	study	NOUN
gsrj-12	50	39	,	,	PUNCT
gsrj-12	50	40	surgery	surgery	NOUN
gsrj-12	50	41	was	be	AUX
gsrj-12	50	42	conducted	conduct	VERB
gsrj-12	50	43	to	to	PART
gsrj-12	50	44	alleviate	alleviate	VERB
gsrj-12	50	45	the	the	DET
gsrj-12	50	46	epileptic	epileptic	ADJ
gsrj-12	50	47	condition	condition	NOUN
gsrj-12	50	48	of	of	ADP
gsrj-12	50	49	the	the	DET
gsrj-12	50	50	patients	patient	NOUN
gsrj-12	50	51	,	,	PUNCT
gsrj-12	50	52	during	during	ADP
gsrj-12	50	53	which	which	PRON
gsrj-12	50	54	researchers	researcher	NOUN
gsrj-12	50	55	intraoperatively	intraoperatively	ADV
gsrj-12	50	56	measured	measure	VERB
gsrj-12	50	57	10	10	NUM
gsrj-12	50	58	-	-	PUNCT
gsrj-12	50	59	ohcbz	ohcbz	NOUN
gsrj-12	50	60	levels	level	NOUN
gsrj-12	50	61	to	to	ADP
gsrj-12	50	62	103	103	NUM
gsrj-12	50	63	georgetown	georgetown	PROPN
gsrj-12	50	64	scientific	scientific	PROPN
gsrj-12	50	65	research	research	NOUN
gsrj-12	50	66	journal	journal	PROPN
gsrj-12	50	67	https://doi.org/10.48091/uwyg8998	https://doi.org/10.48091/uwyg8998	PROPN
gsrj-12	50	68	determine	determine	VERB
gsrj-12	50	69	if	if	SCONJ
gsrj-12	50	70	it	it	PRON
gsrj-12	50	71	is	be	AUX
gsrj-12	50	72	a	a	DET
gsrj-12	50	73	substrate	substrate	NOUN
gsrj-12	50	74	of	of	ADP
gsrj-12	50	75	p	p	NOUN
gsrj-12	50	76	-	-	PUNCT
gsrj-12	50	77	gp	gp	NOUN
gsrj-12	50	78	and	and	CCONJ
gsrj-12	50	79	to	to	PART
gsrj-12	50	80	understand	understand	VERB
gsrj-12	50	81	the	the	DET
gsrj-12	50	82	relationship	relationship	NOUN
gsrj-12	50	83	between	between	ADP
gsrj-12	50	84	its	its	PRON
gsrj-12	50	85	brain	brain	NOUN
gsrj-12	50	86	-	-	PUNCT
gsrj-12	50	87	toplasma	toplasma	NOUN
gsrj-12	50	88	concentration	concentration	NOUN
gsrj-12	50	89	ratio	ratio	NOUN
gsrj-12	50	90	and	and	CCONJ
gsrj-12	50	91	the	the	DET
gsrj-12	50	92	levels	level	NOUN
gsrj-12	50	93	of	of	ADP
gsrj-12	50	94	expression	expression	NOUN
gsrj-12	50	95	of	of	ADP
gsrj-12	50	96	p	p	NOUN
gsrj-12	50	97	-	-	PUNCT
gsrj-12	50	98	gp	gp	NOUN
gsrj-12	50	99	.	.	PUNCT
gsrj-12	51	1	the	the	DET
gsrj-12	51	2	results	result	NOUN
gsrj-12	51	3	showed	show	VERB
gsrj-12	51	4	that	that	SCONJ
gsrj-12	51	5	10ohcbz	10ohcbz	NUM
gsrj-12	51	6	acts	act	NOUN
gsrj-12	51	7	as	as	ADP
gsrj-12	51	8	a	a	DET
gsrj-12	51	9	substrate	substrate	NOUN
gsrj-12	51	10	for	for	ADP
gsrj-12	51	11	p	p	NOUN
gsrj-12	51	12	-	-	PUNCT
gsrj-12	51	13	gp	gp	NOUN
gsrj-12	51	14	,	,	PUNCT
gsrj-12	51	15	and	and	CCONJ
gsrj-12	51	16	the	the	DET
gsrj-12	51	17	concentration	concentration	NOUN
gsrj-12	51	18	of	of	ADP
gsrj-12	51	19	10	10	NUM
gsrj-12	51	20	-	-	PUNCT
gsrj-12	51	21	ohcbz	ohcbz	NOUN
gsrj-12	51	22	in	in	ADP
gsrj-12	51	23	the	the	DET
gsrj-12	51	24	brain	brain	NOUN
gsrj-12	51	25	was	be	AUX
gsrj-12	51	26	not	not	PART
gsrj-12	51	27	correlated	correlate	VERB
gsrj-12	51	28	to	to	ADP
gsrj-12	51	29	the	the	DET
gsrj-12	51	30	plasma	plasma	NOUN
gsrj-12	51	31	levels	level	NOUN
gsrj-12	51	32	of	of	ADP
gsrj-12	51	33	the	the	DET
gsrj-12	51	34	patients	patient	NOUN
gsrj-12	51	35	.	.	PUNCT
gsrj-12	52	1	however	however	ADV
gsrj-12	52	2	,	,	PUNCT
gsrj-12	52	3	a	a	DET
gsrj-12	52	4	significant	significant	ADJ
gsrj-12	52	5	inverse	inverse	NOUN
gsrj-12	52	6	linear	linear	NOUN
gsrj-12	52	7	relationship	relationship	NOUN
gsrj-12	52	8	was	be	AUX
gsrj-12	52	9	found	find	VERB
gsrj-12	52	10	between	between	ADP
gsrj-12	52	11	the	the	DET
gsrj-12	52	12	levels	level	NOUN
gsrj-12	52	13	of	of	ADP
gsrj-12	52	14	expression	expression	NOUN
gsrj-12	52	15	of	of	ADP
gsrj-12	52	16	pgp	pgp	NOUN
gsrj-12	52	17	and	and	CCONJ
gsrj-12	52	18	the	the	DET
gsrj-12	52	19	brain	brain	NOUN
gsrj-12	52	20	-	-	PUNCT
gsrj-12	52	21	to	to	ADP
gsrj-12	52	22	-	-	PUNCT
gsrj-12	52	23	plasma	plasma	NOUN
gsrj-12	52	24	concentration	concentration	NOUN
gsrj-12	52	25	ratio	ratio	NOUN
gsrj-12	52	26	of	of	ADP
gsrj-12	52	27	10	10	NUM
gsrj-12	52	28	-	-	PUNCT
gsrj-12	52	29	ohcbz.14	ohcbz.14	PRON
gsrj-12	52	30	this	this	DET
gsrj-12	52	31	inverse	inverse	NOUN
gsrj-12	52	32	relationship	relationship	NOUN
gsrj-12	52	33	showed	show	VERB
gsrj-12	52	34	that	that	SCONJ
gsrj-12	52	35	higher	high	ADJ
gsrj-12	52	36	levels	level	NOUN
gsrj-12	52	37	of	of	ADP
gsrj-12	52	38	p	p	NOUN
gsrj-12	52	39	-	-	PUNCT
gsrj-12	52	40	gp	gp	NOUN
gsrj-12	52	41	resulted	result	VERB
gsrj-12	52	42	in	in	ADP
gsrj-12	52	43	lower	low	ADJ
gsrj-12	52	44	levels	level	NOUN
gsrj-12	52	45	of	of	ADP
gsrj-12	52	46	the	the	DET
gsrj-12	52	47	active	active	ADJ
gsrj-12	52	48	metabolite	metabolite	NOUN
gsrj-12	52	49	past	past	ADP
gsrj-12	52	50	the	the	DET
gsrj-12	52	51	bbb	bbb	PROPN
gsrj-12	52	52	,	,	PUNCT
gsrj-12	52	53	providing	provide	VERB
gsrj-12	52	54	evidence	evidence	NOUN
gsrj-12	52	55	of	of	ADP
gsrj-12	52	56	the	the	DET
gsrj-12	52	57	hypothesized	hypothesized	ADJ
gsrj-12	52	58	p	p	NOUN
gsrj-12	52	59	-	-	PUNCT
gsrj-12	52	60	gp	gp	NOUN
gsrj-12	52	61	mechanisms	mechanism	NOUN
gsrj-12	52	62	.	.	PUNCT
gsrj-12	53	1	the	the	DET
gsrj-12	53	2	conclusions	conclusion	NOUN
gsrj-12	53	3	of	of	ADP
gsrj-12	53	4	10	10	NUM
gsrj-12	53	5	-	-	PUNCT
gsrj-12	53	6	ohcbz	ohcbz	NOUN
gsrj-12	53	7	apply	apply	VERB
gsrj-12	53	8	to	to	ADP
gsrj-12	53	9	aeds	aed	NOUN
gsrj-12	53	10	because	because	SCONJ
gsrj-12	53	11	the	the	DET
gsrj-12	53	12	data	datum	NOUN
gsrj-12	53	13	showed	show	VERB
gsrj-12	53	14	that	that	SCONJ
gsrj-12	53	15	higher	high	ADJ
gsrj-12	53	16	expressions	expression	NOUN
gsrj-12	53	17	of	of	ADP
gsrj-12	53	18	p	p	NOUN
gsrj-12	53	19	-	-	PUNCT
gsrj-12	53	20	gp	gp	NOUN
gsrj-12	53	21	lead	lead	NOUN
gsrj-12	53	22	to	to	ADP
gsrj-12	53	23	lower	low	ADJ
gsrj-12	53	24	expressions	expression	NOUN
gsrj-12	53	25	of	of	ADP
gsrj-12	53	26	10	10	NUM
gsrj-12	53	27	-	-	PUNCT
gsrj-12	53	28	ohcbz	ohcbz	NOUN
gsrj-12	53	29	,	,	PUNCT
gsrj-12	53	30	�	�	PROPN
gsrj-12	53	31	and	and	CCONJ
gsrj-12	53	32	intracellular	intracellular	ADJ
gsrj-12	53	33	levels	level	NOUN
gsrj-12	53	34	of	of	ADP
gsrj-12	53	35	the	the	DET
gsrj-12	53	36	metabolite	metabolite	NOUN
gsrj-12	53	37	were	be	AUX
gsrj-12	53	38	�	�	NOUN
gsrj-12	53	39	increased	increase	VERB
gsrj-12	53	40	when	when	SCONJ
gsrj-12	53	41	xr9576	xr9576	PROPN
gsrj-12	53	42	,	,	PUNCT
gsrj-12	53	43	a	a	DET
gsrj-12	53	44	p	p	NOUN
gsrj-12	53	45	-	-	PUNCT
gsrj-12	53	46	gp	gp	NOUN
gsrj-12	53	47	inhibitor	inhibitor	NOUN
gsrj-12	53	48	,	,	PUNCT
gsrj-12	53	49	was	be	AUX
gsrj-12	53	50	�	�	PROPN
gsrj-12	53	51	introduced	introduce	VERB
gsrj-12	53	52	.	.	PUNCT
gsrj-12	54	1	however	however	ADV
gsrj-12	54	2	,	,	PUNCT
gsrj-12	54	3	these	these	DET
gsrj-12	54	4	conclusions	conclusion	NOUN
gsrj-12	54	5	are	be	AUX
gsrj-12	54	6	not	not	PART
gsrj-12	54	7	�	�	PROPN
gsrj-12	54	8	necessarily	necessarily	ADV
gsrj-12	54	9	reliable	reliable	ADJ
gsrj-12	54	10	due	due	ADP
gsrj-12	54	11	to	to	ADP
gsrj-12	54	12	the	the	DET
gsrj-12	54	13	lack	lack	NOUN
gsrj-12	54	14	of	of	ADP
gsrj-12	54	15	control	control	NOUN
gsrj-12	54	16	brain	brain	NOUN
gsrj-12	54	17	�	�	PROPN
gsrj-12	54	18	tissue	tissue	NOUN
gsrj-12	54	19	from	from	ADP
gsrj-12	54	20	drug	drug	NOUN
gsrj-12	54	21	-	-	PUNCT
gsrj-12	54	22	responding	respond	VERB
gsrj-12	54	23	patients	patient	NOUN
gsrj-12	54	24	.	.	PUNCT
gsrj-12	55	1	�	�	PROPN
gsrj-12	55	2	furthermore	furthermore	ADV
gsrj-12	55	3	,	,	PUNCT
gsrj-12	55	4	in	in	ADP
gsrj-12	55	5	-	-	PUNCT
gsrj-12	55	6	vitro	vitro	X
gsrj-12	55	7	studies	study	NOUN
gsrj-12	55	8	do	do	AUX
gsrj-12	55	9	not	not	PART
gsrj-12	55	10	necessarily	necessarily	ADV
gsrj-12	55	11	�	�	NOUN
gsrj-12	55	12	confirm	confirm	VERB
gsrj-12	55	13	or	or	CCONJ
gsrj-12	55	14	reflect	reflect	VERB
gsrj-12	55	15	these	these	DET
gsrj-12	55	16	mechanisms	mechanism	NOUN
gsrj-12	55	17	as	as	SCONJ
gsrj-12	55	18	would	would	AUX
gsrj-12	55	19	invivo	invivo	VERB
gsrj-12	55	20	models	model	NOUN
gsrj-12	55	21	for	for	ADP
gsrj-12	55	22	refractory	refractory	NOUN
gsrj-12	55	23	epilepsy.13	epilepsy.13	PROPN
gsrj-12	55	24	the	the	DET
gsrj-12	55	25	�	�	PROPN
gsrj-12	55	26	observational	observational	ADJ
gsrj-12	55	27	nature	nature	NOUN
gsrj-12	55	28	of	of	ADP
gsrj-12	55	29	the	the	DET
gsrj-12	55	30	previous	previous	ADJ
gsrj-12	55	31	study	study	NOUN
gsrj-12	55	32	is	be	AUX
gsrj-12	55	33	useful	useful	ADJ
gsrj-12	55	34	�	�	NOUN
gsrj-12	55	35	in	in	ADP
gsrj-12	55	36	developing	develop	VERB
gsrj-12	55	37	a	a	DET
gsrj-12	55	38	base	base	NOUN
gsrj-12	55	39	for	for	ADP
gsrj-12	55	40	understanding	understand	VERB
gsrj-12	55	41	the	the	DET
gsrj-12	55	42	�	�	PROPN
gsrj-12	55	43	functions	function	NOUN
gsrj-12	55	44	of	of	ADP
gsrj-12	55	45	p	p	NOUN
gsrj-12	55	46	-	-	PUNCT
gsrj-12	55	47	gp	gp	NOUN
gsrj-12	55	48	and	and	CCONJ
gsrj-12	55	49	developing	develop	VERB
gsrj-12	55	50	hypotheses	hypothesis	NOUN
gsrj-12	55	51	,	,	PUNCT
gsrj-12	55	52	but	but	CCONJ
gsrj-12	55	53	�	�	PROPN
gsrj-12	55	54	in	in	ADP
gsrj-12	55	55	-	-	PUNCT
gsrj-12	55	56	vivo	vivo	NOUN
gsrj-12	55	57	studies	study	NOUN
gsrj-12	55	58	are	be	AUX
gsrj-12	55	59	needed	need	VERB
gsrj-12	55	60	to	to	PART
gsrj-12	55	61	test	test	VERB
gsrj-12	55	62	and	and	CCONJ
gsrj-12	55	63	prove	prove	VERB
gsrj-12	55	64	these	these	DET
gsrj-12	55	65	�	�	PROPN
gsrj-12	55	66	hypotheses	hypothesis	NOUN
gsrj-12	55	67	.	.	PUNCT
gsrj-12	56	1	nevertheless	nevertheless	ADV
gsrj-12	56	2	,	,	PUNCT
gsrj-12	56	3	this	this	DET
gsrj-12	56	4	pilot	pilot	NOUN
gsrj-12	56	5	study	study	NOUN
gsrj-12	56	6	still	still	ADV
gsrj-12	56	7	�	�	PROPN
gsrj-12	56	8	provided	provide	VERB
gsrj-12	56	9	some	some	DET
gsrj-12	56	10	fundamental	fundamental	ADJ
gsrj-12	56	11	insight	insight	NOUN
gsrj-12	56	12	into	into	ADP
gsrj-12	56	13	the	the	DET
gsrj-12	56	14	�	�	PROPN
gsrj-12	56	15	mechanisms	mechanism	NOUN
gsrj-12	56	16	of	of	ADP
gsrj-12	56	17	p	p	NOUN
gsrj-12	56	18	-	-	PUNCT
gsrj-12	56	19	gp	gp	NOUN
gsrj-12	56	20	overexpression	overexpression	NOUN
gsrj-12	56	21	�	�	NOUN
gsrj-12	56	22	in	in	ADP
gsrj-12	56	23	pharmacoresistance	pharmacoresistance	NOUN
gsrj-12	56	24	and	and	CCONJ
gsrj-12	56	25	demonstrated	demonstrate	VERB
gsrj-12	56	26	how	how	SCONJ
gsrj-12	56	27	�	�	PROPN
gsrj-12	56	28	substrates	substrate	NOUN
gsrj-12	56	29	of	of	ADP
gsrj-12	56	30	p	p	NOUN
gsrj-12	56	31	-	-	PUNCT
gsrj-12	56	32	gp	gp	NOUN
gsrj-12	56	33	,	,	PUNCT
gsrj-12	56	34	including	include	VERB
gsrj-12	56	35	aeds	aed	NOUN
gsrj-12	56	36	,	,	PUNCT
gsrj-12	56	37	have	have	VERB
gsrj-12	56	38	�	�	NOUN
gsrj-12	56	39	difficulty	difficulty	NOUN
gsrj-12	56	40	crossing	cross	VERB
gsrj-12	56	41	the	the	DET
gsrj-12	56	42	bbb	bbb	NOUN
gsrj-12	56	43	and	and	CCONJ
gsrj-12	56	44	reaching	reach	VERB
gsrj-12	56	45	the	the	DET
gsrj-12	56	46	brain	brain	NOUN
gsrj-12	56	47	�	�	PROPN
gsrj-12	56	48	if	if	SCONJ
gsrj-12	56	49	there	there	PRON
gsrj-12	56	50	is	be	VERB
gsrj-12	56	51	an	an	DET
gsrj-12	56	52	overexpression	overexpression	NOUN
gsrj-12	56	53	of	of	ADP
gsrj-12	56	54	these	these	DET
gsrj-12	56	55	transporters	transporter	NOUN
gsrj-12	56	56	.	.	PUNCT
gsrj-12	57	1	an	an	DET
gsrj-12	57	2	in	in	ADP
gsrj-12	57	3	-	-	PUNCT
gsrj-12	57	4	vivo	vivo	NOUN
gsrj-12	57	5	study	study	NOUN
gsrj-12	57	6	by	by	ADP
gsrj-12	57	7	van	van	PROPN
gsrj-12	57	8	vliet	vliet	PROPN
gsrj-12	57	9	et	et	PROPN
gsrj-12	57	10	al	al	PROPN
gsrj-12	57	11	.	.	PROPN
gsrj-12	57	12	measured	measure	VERB
gsrj-12	57	13	the	the	DET
gsrj-12	57	14	levels	level	NOUN
gsrj-12	57	15	of	of	ADP
gsrj-12	57	16	phenytoin	phenytoin	PROPN
gsrj-12	57	17	(	(	PUNCT
gsrj-12	57	18	pht	pht	PROPN
gsrj-12	57	19	)	)	PUNCT
gsrj-12	57	20	,	,	PUNCT
gsrj-12	57	21	a	a	DET
gsrj-12	57	22	common	common	ADJ
gsrj-12	57	23	aed	aed	NOUN
gsrj-12	57	24	used	use	VERB
gsrj-12	57	25	to	to	PART
gsrj-12	57	26	control	control	VERB
gsrj-12	57	27	seizures	seizure	NOUN
gsrj-12	57	28	,	,	PUNCT
gsrj-12	57	29	in	in	ADP
gsrj-12	57	30	different	different	ADJ
gsrj-12	57	31	brain	brain	NOUN
gsrj-12	57	32	regions	region	NOUN
gsrj-12	57	33	of	of	ADP
gsrj-12	57	34	both	both	CCONJ
gsrj-12	57	35	epileptic	epileptic	ADJ
gsrj-12	57	36	and	and	CCONJ
gsrj-12	57	37	nonepileptic	nonepileptic	ADJ
gsrj-12	57	38	rats.15	rats.15	NOUN
gsrj-12	57	39	the	the	DET
gsrj-12	57	40	researchers	researcher	NOUN
gsrj-12	57	41	wanted	want	VERB
gsrj-12	57	42	to	to	PART
gsrj-12	57	43	compare	compare	VERB
gsrj-12	57	44	pht	pht	PROPN
gsrj-12	57	45	levels	level	NOUN
gsrj-12	57	46	in	in	ADP
gsrj-12	57	47	regions	region	NOUN
gsrj-12	57	48	of	of	ADP
gsrj-12	57	49	the	the	DET
gsrj-12	57	50	brain	brain	NOUN
gsrj-12	57	51	with	with	ADP
gsrj-12	57	52	an	an	DET
gsrj-12	57	53	overexpression	overexpression	NOUN
gsrj-12	57	54	of	of	ADP
gsrj-12	57	55	p	p	NOUN
gsrj-12	57	56	-	-	PUNCT
gsrj-12	57	57	gp	gp	NOUN
gsrj-12	57	58	,	,	PUNCT
gsrj-12	57	59	such	such	ADJ
gsrj-12	57	60	as	as	ADP
gsrj-12	57	61	the	the	DET
gsrj-12	57	62	parahippocampal	parahippocampal	ADJ
gsrj-12	57	63	cortex	cortex	NOUN
gsrj-12	57	64	and	and	CCONJ
gsrj-12	57	65	the	the	DET
gsrj-12	57	66	temporal	temporal	ADJ
gsrj-12	57	67	hippocampus	hippocampus	NOUN
gsrj-12	57	68	,	,	PUNCT
gsrj-12	57	69	to	to	PART
gsrj-12	57	70	pht	pht	VERB
gsrj-12	57	71	levels	level	NOUN
gsrj-12	57	72	in	in	ADP
gsrj-12	57	73	brain	brain	NOUN
gsrj-12	57	74	regions	region	NOUN
gsrj-12	57	75	with	with	ADP
gsrj-12	57	76	lower	low	ADJ
gsrj-12	57	77	p	p	NOUN
gsrj-12	57	78	-	-	PUNCT
gsrj-12	57	79	gp	gp	NOUN
gsrj-12	57	80	expression	expression	NOUN
gsrj-12	57	81	.	.	PUNCT
gsrj-12	58	1	the	the	DET
gsrj-12	58	2	concentration	concentration	NOUN
gsrj-12	58	3	of	of	ADP
gsrj-12	58	4	pht	pht	PROPN
gsrj-12	58	5	in	in	ADP
gsrj-12	58	6	regions	region	NOUN
gsrj-12	58	7	with	with	ADP
gsrj-12	58	8	overexpression	overexpression	NOUN
gsrj-12	58	9	of	of	ADP
gsrj-12	58	10	p	p	NOUN
gsrj-12	58	11	-	-	PUNCT
gsrj-12	58	12	gp	gp	NOUN
gsrj-12	58	13	was	be	AUX
gsrj-12	58	14	significantly	significantly	ADV
gsrj-12	58	15	reduced	reduce	VERB
gsrj-12	58	16	compared	compare	VERB
gsrj-12	58	17	to	to	ADP
gsrj-12	58	18	regions	region	NOUN
gsrj-12	58	19	with	with	ADP
gsrj-12	58	20	lower	low	ADJ
gsrj-12	58	21	p	p	NOUN
gsrj-12	58	22	-	-	PUNCT
gsrj-12	58	23	gp	gp	NOUN
gsrj-12	58	24	expression	expression	NOUN
gsrj-12	58	25	.	.	PUNCT
gsrj-12	59	1	these	these	DET
gsrj-12	59	2	results	result	NOUN
gsrj-12	59	3	were	be	AUX
gsrj-12	59	4	,	,	PUNCT
gsrj-12	59	5	once	once	ADV
gsrj-12	59	6	again	again	ADV
gsrj-12	59	7	,	,	PUNCT
gsrj-12	59	8	consistent	consistent	ADJ
gsrj-12	59	9	with	with	ADP
gsrj-12	59	10	the	the	DET
gsrj-12	59	11	earlier	early	ADJ
gsrj-12	59	12	findings	finding	NOUN
gsrj-12	59	13	,	,	PUNCT
gsrj-12	59	14	demonstrating	demonstrate	VERB
gsrj-12	59	15	the	the	DET
gsrj-12	59	16	relationship	relationship	NOUN
gsrj-12	59	17	between	between	ADP
gsrj-12	59	18	increased	increase	VERB
gsrj-12	59	19	p	p	NOUN
gsrj-12	59	20	-	-	PUNCT
gsrj-12	59	21	gp	gp	NOUN
gsrj-12	59	22	expression	expression	NOUN
gsrj-12	59	23	and	and	CCONJ
gsrj-12	59	24	decreased	decrease	VERB
gsrj-12	59	25	levels	level	NOUN
gsrj-12	59	26	of	of	ADP
gsrj-12	59	27	aed	aed	NOUN
gsrj-12	59	28	in	in	ADP
gsrj-12	59	29	the	the	DET
gsrj-12	59	30	brain.15	brain.15	NOUN
gsrj-12	59	31	overall	overall	ADV
gsrj-12	59	32	,	,	PUNCT
gsrj-12	59	33	it	it	PRON
gsrj-12	59	34	has	have	AUX
gsrj-12	59	35	been	be	AUX
gsrj-12	59	36	established	establish	VERB
gsrj-12	59	37	,	,	PUNCT
gsrj-12	59	38	through	through	ADP
gsrj-12	59	39	studies	study	NOUN
gsrj-12	59	40	using	use	VERB
gsrj-12	59	41	different	different	ADJ
gsrj-12	59	42	aed	aed	NOUN
gsrj-12	59	43	substrates	substrate	NOUN
gsrj-12	59	44	and	and	CCONJ
gsrj-12	59	45	refractory	refractory	NOUN
gsrj-12	59	46	epilepsy	epilepsy	NOUN
gsrj-12	59	47	models	model	NOUN
gsrj-12	59	48	,	,	PUNCT
gsrj-12	59	49	that	that	SCONJ
gsrj-12	59	50	the	the	DET
gsrj-12	59	51	overexpression	overexpression	NOUN
gsrj-12	59	52	of	of	ADP
gsrj-12	59	53	p	p	NOUN
gsrj-12	59	54	-	-	PUNCT
gsrj-12	59	55	gp	gp	NOUN
gsrj-12	59	56	efflux	efflux	NOUN
gsrj-12	59	57	transporters	transporter	NOUN
gsrj-12	59	58	leads	lead	VERB
gsrj-12	59	59	to	to	ADP
gsrj-12	59	60	decreased	decrease	VERB
gsrj-12	59	61	concentration	concentration	NOUN
gsrj-12	59	62	of	of	ADP
gsrj-12	59	63	aeds	aed	NOUN
gsrj-12	59	64	in	in	ADP
gsrj-12	59	65	the	the	DET
gsrj-12	59	66	brain	brain	NOUN
gsrj-12	59	67	and	and	CCONJ
gsrj-12	59	68	,	,	PUNCT
gsrj-12	59	69	consequently	consequently	ADV
gsrj-12	59	70	,	,	PUNCT
gsrj-12	59	71	pharmacoresistance	pharmacoresistance	PROPN
gsrj-12	59	72	.	.	PUNCT
gsrj-12	60	1	some	some	PRON
gsrj-12	60	2	of	of	ADP
gsrj-12	60	3	these	these	DET
gsrj-12	60	4	studies	study	NOUN
gsrj-12	60	5	have	have	AUX
gsrj-12	60	6	also	also	ADV
gsrj-12	60	7	suggested	suggest	VERB
gsrj-12	60	8	this	this	DET
gsrj-12	60	9	mechanism	mechanism	NOUN
gsrj-12	60	10	as	as	ADP
gsrj-12	60	11	a	a	DET
gsrj-12	60	12	potential	potential	ADJ
gsrj-12	60	13	therapeutic	therapeutic	ADJ
gsrj-12	60	14	target	target	NOUN
gsrj-12	60	15	,	,	PUNCT
gsrj-12	60	16	specifically	specifically	ADV
gsrj-12	60	17	with	with	ADP
gsrj-12	60	18	the	the	DET
gsrj-12	60	19	use	use	NOUN
gsrj-12	60	20	of	of	ADP
gsrj-12	60	21	p	p	NOUN
gsrj-12	60	22	-	-	PUNCT
gsrj-12	60	23	gp	gp	NOUN
gsrj-12	60	24	inhibitors.15,16	inhibitors.15,16	NOUN
gsrj-12	60	25	together	together	ADV
gsrj-12	60	26	,	,	PUNCT
gsrj-12	60	27	the	the	DET
gsrj-12	60	28	findings	finding	NOUN
gsrj-12	60	29	of	of	ADP
gsrj-12	60	30	these	these	DET
gsrj-12	60	31	past	past	ADJ
gsrj-12	60	32	works	work	NOUN
gsrj-12	60	33	suggest	suggest	VERB
gsrj-12	60	34	promising	promise	VERB
gsrj-12	60	35	research	research	NOUN
gsrj-12	60	36	implications	implication	NOUN
gsrj-12	60	37	for	for	ADP
gsrj-12	60	38	p	p	NOUN
gsrj-12	60	39	-	-	PUNCT
gsrj-12	60	40	gps	gps	NOUN
gsrj-12	60	41	as	as	ADP
gsrj-12	60	42	future	future	ADJ
gsrj-12	60	43	treatment	treatment	NOUN
gsrj-12	60	44	targets	target	NOUN
gsrj-12	60	45	,	,	PUNCT
gsrj-12	60	46	which	which	PRON
gsrj-12	60	47	will	will	AUX
gsrj-12	60	48	be	be	AUX
gsrj-12	60	49	discussed	discuss	VERB
gsrj-12	60	50	in	in	ADP
gsrj-12	60	51	the	the	DET
gsrj-12	60	52	next	next	ADJ
gsrj-12	60	53	section	section	NOUN
gsrj-12	60	54	.	.	PUNCT
gsrj-12	61	1	4	4	X
gsrj-12	61	2	.	.	X
gsrj-12	61	3	improving	improve	VERB
gsrj-12	61	4	standard	standard	NOUN
gsrj-12	61	5	of	of	ADP
gsrj-12	61	6	care	care	NOUN
gsrj-12	61	7	for	for	ADP
gsrj-12	61	8	refractory	refractory	NOUN
gsrj-12	61	9	epilepsy	epilepsy	VERB
gsrj-12	61	10	4.1	4.1	NUM
gsrj-12	61	11	significance	significance	NOUN
gsrj-12	61	12	of	of	ADP
gsrj-12	61	13	p	p	NOUN
gsrj-12	61	14	-	-	PUNCT
gsrj-12	61	15	gp	gp	NOUN
gsrj-12	61	16	inhibitors	inhibitor	NOUN
gsrj-12	61	17	in	in	ADP
gsrj-12	61	18	reducing	reduce	VERB
gsrj-12	61	19	pharmacoresistance	pharmacoresistance	NOUN
gsrj-12	61	20	although	although	SCONJ
gsrj-12	61	21	overexpression	overexpression	NOUN
gsrj-12	61	22	of	of	ADP
gsrj-12	61	23	p	p	NOUN
gsrj-12	61	24	-	-	PUNCT
gsrj-12	61	25	gps	gps	PROPN
gsrj-12	61	26	has	have	AUX
gsrj-12	61	27	been	be	AUX
gsrj-12	61	28	identified	identify	VERB
gsrj-12	61	29	as	as	ADP
gsrj-12	61	30	a	a	DET
gsrj-12	61	31	highly	highly	ADV
gsrj-12	61	32	probable	probable	ADJ
gsrj-12	61	33	mechanism	mechanism	NOUN
gsrj-12	61	34	of	of	ADP
gsrj-12	61	35	drug	drug	NOUN
gsrj-12	61	36	resistance	resistance	NOUN
gsrj-12	61	37	in	in	ADP
gsrj-12	61	38	epilepsy	epilepsy	NOUN
gsrj-12	61	39	,	,	PUNCT
gsrj-12	61	40	treatment	treatment	NOUN
gsrj-12	61	41	methods	method	NOUN
gsrj-12	61	42	have	have	VERB
gsrj-12	61	43	yet	yet	ADV
gsrj-12	61	44	to	to	PART
gsrj-12	61	45	significantly	significantly	ADV
gsrj-12	61	46	account	account	VERB
gsrj-12	61	47	for	for	ADP
gsrj-12	61	48	this	this	DET
gsrj-12	61	49	new	new	ADJ
gsrj-12	61	50	knowledge	knowledge	NOUN
gsrj-12	61	51	.	.	PUNCT
gsrj-12	62	1	a	a	DET
gsrj-12	62	2	promising	promising	ADJ
gsrj-12	62	3	yet	yet	CCONJ
gsrj-12	62	4	relatively	relatively	ADV
gsrj-12	62	5	unexplored	unexplored	ADJ
gsrj-12	62	6	treatment	treatment	NOUN
gsrj-12	62	7	option	option	NOUN
gsrj-12	62	8	lies	lie	VERB
gsrj-12	62	9	in	in	ADP
gsrj-12	62	10	therapeutics	therapeutic	NOUN
gsrj-12	62	11	that	that	PRON
gsrj-12	62	12	target	target	VERB
gsrj-12	62	13	the	the	DET
gsrj-12	62	14	activity	activity	NOUN
gsrj-12	62	15	of	of	ADP
gsrj-12	62	16	p	p	NOUN
gsrj-12	62	17	-	-	PUNCT
gsrj-12	62	18	gps	gps	NOUN
gsrj-12	62	19	.	.	PUNCT
gsrj-12	63	1	p	p	X
gsrj-12	63	2	-	-	PUNCT
gsrj-12	63	3	gp	gp	NOUN
gsrj-12	63	4	inhibitors	inhibitor	NOUN
gsrj-12	63	5	are	be	AUX
gsrj-12	63	6	a	a	DET
gsrj-12	63	7	specialized	specialized	ADJ
gsrj-12	63	8	class	class	NOUN
gsrj-12	63	9	of	of	ADP
gsrj-12	63	10	substances	substance	NOUN
gsrj-12	63	11	that	that	PRON
gsrj-12	63	12	block	block	VERB
gsrj-12	63	13	or	or	CCONJ
gsrj-12	63	14	bypass	bypass	VERB
gsrj-12	63	15	the	the	DET
gsrj-12	63	16	efflux	efflux	NOUN
gsrj-12	63	17	activity	activity	NOUN
gsrj-12	63	18	of	of	ADP
gsrj-12	63	19	p	p	NOUN
gsrj-12	63	20	-	-	PUNCT
gsrj-12	63	21	gps	gps	NOUN
gsrj-12	63	22	at	at	ADP
gsrj-12	63	23	the	the	DET
gsrj-12	63	24	bbb.16	bbb.16	NOUN
gsrj-12	63	25	in	in	ADP
gsrj-12	63	26	regards	regard	NOUN
gsrj-12	63	27	to	to	ADP
gsrj-12	63	28	aeds	aed	NOUN
gsrj-12	63	29	specifically	specifically	ADV
gsrj-12	63	30	,	,	PUNCT
gsrj-12	63	31	these	these	DET
gsrj-12	63	32	inhibitors	inhibitor	NOUN
gsrj-12	63	33	work	work	VERB
gsrj-12	63	34	to	to	PART
gsrj-12	63	35	prevent	prevent	VERB
gsrj-12	63	36	the	the	DET
gsrj-12	63	37	efflux	efflux	NOUN
gsrj-12	63	38	of	of	ADP
gsrj-12	63	39	aeds	aed	NOUN
gsrj-12	63	40	from	from	ADP
gsrj-12	63	41	endothelial	endothelial	ADJ
gsrj-12	63	42	cells	cell	NOUN
gsrj-12	63	43	of	of	ADP
gsrj-12	63	44	the	the	DET
gsrj-12	63	45	blood	blood	NOUN
gsrj-12	63	46	brain	brain	NOUN
gsrj-12	63	47	barrier	barrier	NOUN
gsrj-12	63	48	(	(	PUNCT
gsrj-12	63	49	figure	figure	NOUN
gsrj-12	63	50	1	1	NUM
gsrj-12	63	51	)	)	PUNCT
gsrj-12	63	52	,	,	PUNCT
gsrj-12	63	53	thus	thus	ADV
gsrj-12	63	54	allowing	allow	VERB
gsrj-12	63	55	for	for	ADP
gsrj-12	63	56	increased	increase	VERB
gsrj-12	63	57	therapeutic	therapeutic	ADJ
gsrj-12	63	58	effect	effect	NOUN
gsrj-12	63	59	.	.	PUNCT
gsrj-12	64	1	these	these	DET
gsrj-12	64	2	inhibitors	inhibitor	NOUN
gsrj-12	64	3	function	function	VERB
gsrj-12	64	4	to	to	ADP
gsrj-12	64	5	either	either	CCONJ
gsrj-12	64	6	block	block	VERB
gsrj-12	64	7	p	p	NOUN
gsrj-12	64	8	-	-	PUNCT
gsrj-12	64	9	gp	gp	NOUN
gsrj-12	64	10	binding	bind	VERB
gsrj-12	64	11	sites	site	NOUN
gsrj-12	64	12	,	,	PUNCT
gsrj-12	64	13	reduce	reduce	VERB
gsrj-12	64	14	atp	atp	NOUN
gsrj-12	64	15	hydrolysis	hydrolysis	NOUN
gsrj-12	64	16	by	by	ADP
gsrj-12	64	17	p	p	NOUN
gsrj-12	64	18	-	-	PUNCT
gsrj-12	64	19	gp	gp	NOUN
gsrj-12	64	20	,	,	PUNCT
gsrj-12	64	21	or	or	CCONJ
gsrj-12	64	22	weaken	weaken	VERB
gsrj-12	64	23	cell	cell	NOUN
gsrj-12	64	24	membrane	membrane	NOUN
gsrj-12	64	25	lipids.16	lipids.16	NOUN
gsrj-12	64	26	the	the	DET
gsrj-12	64	27	previously	previously	ADV
gsrj-12	64	28	mentioned	mention	VERB
gsrj-12	64	29	in	in	ADP
gsrj-12	64	30	-	-	PUNCT
gsrj-12	64	31	vitro	vitro	X
gsrj-12	64	32	study	study	NOUN
gsrj-12	64	33	using	use	VERB
gsrj-12	64	34	10	10	NUM
gsrj-12	64	35	-	-	PUNCT
gsrj-12	64	36	ohcbz	ohcbz	NOUN
gsrj-12	64	37	to	to	PART
gsrj-12	64	38	observe	observe	VERB
gsrj-12	64	39	the	the	DET
gsrj-12	64	40	effect	effect	NOUN
gsrj-12	64	41	of	of	ADP
gsrj-12	64	42	pgps	pgps	NOUN
gsrj-12	64	43	on	on	ADP
gsrj-12	64	44	intracellular	intracellular	ADJ
gsrj-12	64	45	drug	drug	NOUN
gsrj-12	64	46	concentration	concentration	NOUN
gsrj-12	64	47	briefly	briefly	ADV
gsrj-12	64	48	introduced	introduce	VERB
gsrj-12	64	49	the	the	DET
gsrj-12	64	50	use	use	NOUN
gsrj-12	64	51	of	of	ADP
gsrj-12	64	52	p	p	NOUN
gsrj-12	64	53	-	-	PUNCT
gsrj-12	64	54	gp	gp	NOUN
gsrj-12	64	55	inhibitors	inhibitor	NOUN
gsrj-12	64	56	,	,	PUNCT
gsrj-12	64	57	which	which	PRON
gsrj-12	64	58	resulted	result	VERB
gsrj-12	64	59	in	in	ADP
gsrj-12	64	60	increased	increase	VERB
gsrj-12	64	61	intracellular	intracellular	ADJ
gsrj-12	64	62	drug	drug	NOUN
gsrj-12	64	63	concentration.14	concentration.14	NOUN
gsrj-12	64	64	this	this	DET
gsrj-12	64	65	previous	previous	ADJ
gsrj-12	64	66	work	work	NOUN
gsrj-12	64	67	was	be	AUX
gsrj-12	64	68	able	able	ADJ
gsrj-12	64	69	to	to	PART
gsrj-12	64	70	provide	provide	VERB
gsrj-12	64	71	the	the	DET
gsrj-12	64	72	fundamental	fundamental	ADJ
gsrj-12	64	73	insight	insight	NOUN
gsrj-12	64	74	needed	need	VERB
gsrj-12	64	75	to	to	PART
gsrj-12	64	76	suggest	suggest	VERB
gsrj-12	64	77	that	that	SCONJ
gsrj-12	64	78	concurrent	concurrent	ADJ
gsrj-12	64	79	administration	administration	NOUN
gsrj-12	64	80	of	of	ADP
gsrj-12	64	81	aed	aed	NOUN
gsrj-12	64	82	substrates	substrate	NOUN
gsrj-12	64	83	with	with	ADP
gsrj-12	64	84	p	p	NOUN
gsrj-12	64	85	-	-	PUNCT
gsrj-12	64	86	gp	gp	NOUN
gsrj-12	64	87	inhibitors	inhibitor	NOUN
gsrj-12	64	88	may	may	AUX
gsrj-12	64	89	increase	increase	VERB
gsrj-12	64	90	drug	drug	NOUN
gsrj-12	64	91	104	104	NUM
gsrj-12	64	92	georgetown	georgetown	PROPN
gsrj-12	64	93	scientific	scientific	PROPN
gsrj-12	64	94	research	research	NOUN
gsrj-12	64	95	journal	journal	PROPN
gsrj-12	64	96	https://doi.org/10.48091/uwyg8998	https://doi.org/10.48091/uwyg8998	NOUN
gsrj-12	64	97	bioavailability	bioavailability	NOUN
gsrj-12	64	98	or	or	CCONJ
gsrj-12	64	99	uptake	uptake	ADJ
gsrj-12	64	100	at	at	ADP
gsrj-12	64	101	the	the	DET
gsrj-12	64	102	bbb	bbb	NOUN
gsrj-12	64	103	and	and	CCONJ
gsrj-12	64	104	result	result	VERB
gsrj-12	64	105	in	in	ADP
gsrj-12	64	106	an	an	DET
gsrj-12	64	107	improved	improved	ADJ
gsrj-12	64	108	therapeutic	therapeutic	ADJ
gsrj-12	64	109	effect.14,16	effect.14,16	ADJ
gsrj-12	64	110	figure	figure	NOUN
gsrj-12	64	111	1	1	NUM
gsrj-12	64	112	.	.	PUNCT
gsrj-12	65	1	p	p	X
gsrj-12	65	2	-	-	PUNCT
gsrj-12	65	3	gp	gp	NOUN
gsrj-12	65	4	inhibition	inhibition	NOUN
gsrj-12	65	5	to	to	PART
gsrj-12	65	6	prevent	prevent	VERB
gsrj-12	65	7	aed	aed	NOUN
gsrj-12	65	8	efflux	efflux	NOUN
gsrj-12	65	9	at	at	ADP
gsrj-12	65	10	the	the	DET
gsrj-12	65	11	blood	blood	NOUN
gsrj-12	65	12	brain	brain	NOUN
gsrj-12	65	13	barrier	barrier	NOUN
gsrj-12	65	14	1	1	NUM
gsrj-12	65	15	table	table	NOUN
gsrj-12	65	16	1	1	NUM
gsrj-12	65	17	.	.	PUNCT
gsrj-12	65	18	classification	classification	NOUN
gsrj-12	65	19	and	and	CCONJ
gsrj-12	65	20	limitations	limitation	NOUN
gsrj-12	65	21	of	of	ADP
gsrj-12	65	22	p	p	NOUN
gsrj-12	65	23	-	-	PUNCT
gsrj-12	65	24	g	g	NOUN
gsrj-12	65	25	inhibitors	inhibitor	NOUN
gsrj-12	65	26	generation	generation	NOUN
gsrj-12	65	27	specificit	specificit	NOUN
gsrj-12	65	28	y	y	PROPN
gsrj-12	65	29	limitations	limitation	NOUN
gsrj-12	65	30	advantages	advantage	VERB
gsrj-12	65	31	examples	example	NOUN
gsrj-12	65	32	first	first	ADJ
gsrj-12	65	33	generation	generation	NOUN
gsrj-12	65	34	low	low	ADJ
gsrj-12	65	35	-high	-high	NOUN
gsrj-12	65	36	toxicity	toxicity	NOUN
gsrj-12	65	37	-must	-must	NOUN
gsrj-12	65	38	be	be	AUX
gsrj-12	65	39	administered	administer	VERB
gsrj-12	65	40	in	in	ADP
gsrj-12	65	41	low	low	ADJ
gsrj-12	65	42	doses	dose	NOUN
gsrj-12	65	43	-high	-high	NOUN
gsrj-12	65	44	serum	serum	NOUN
gsrj-12	65	45	concentrations	concentration	NOUN
gsrj-12	65	46	-wide	-wide	ADJ
gsrj-12	65	47	range	range	NOUN
gsrj-12	65	48	of	of	ADP
gsrj-12	65	49	substrate	substrate	NOUN
gsrj-12	65	50	capabilities	capability	NOUN
gsrj-12	65	51	-most	-most	ADJ
gsrj-12	65	52	pharmacologically	pharmacologically	ADV
gsrj-12	65	53	active	active	ADJ
gsrj-12	65	54	-significant	-significant	ADJ
gsrj-12	65	55	research	research	NOUN
gsrj-12	65	56	accomplished	accomplish	VERB
gsrj-12	65	57	verapamil	verapamil	NOUN
gsrj-12	65	58	second	second	ADJ
gsrj-12	65	59	generation	generation	NOUN
gsrj-12	65	60	medium	medium	ADJ
gsrj-12	65	61	-inhibitory	-inhibitory	NOUN
gsrj-12	65	62	effect	effect	NOUN
gsrj-12	65	63	of	of	ADP
gsrj-12	65	64	unintended	unintended	ADJ
gsrj-12	65	65	enzymes	enzyme	NOUN
gsrj-12	65	66	and	and	CCONJ
gsrj-12	65	67	other	other	ADJ
gsrj-12	65	68	abc	abc	PROPN
gsrj-12	65	69	transporters	transporter	NOUN
gsrj-12	65	70	-greater	-greater	NOUN
gsrj-12	65	71	affinity	affinity	NOUN
gsrj-12	65	72	of	of	ADP
gsrj-12	65	73	p	p	NOUN
gsrj-12	65	74	-	-	PUNCT
gsrj-12	65	75	gp	gp	NOUN
gsrj-12	65	76	valspodar	valspodar	PROPN
gsrj-12	65	77	third	third	ADJ
gsrj-12	65	78	generation	generation	NOUN
gsrj-12	65	79	high	high	ADJ
gsrj-12	65	80	-many	-many	PROPN
gsrj-12	65	81	still	still	ADV
gsrj-12	65	82	in	in	ADP
gsrj-12	65	83	developmental	developmental	ADJ
gsrj-12	65	84	stage	stage	NOUN
gsrj-12	65	85	/	/	SYM
gsrj-12	65	86	not	not	PART
gsrj-12	65	87	ready	ready	ADJ
gsrj-12	65	88	for	for	ADP
gsrj-12	65	89	clinical	clinical	ADJ
gsrj-12	65	90	use	use	NOUN
gsrj-12	65	91	-low	-low	NOUN
gsrj-12	65	92	toxicity	toxicity	NOUN
gsrj-12	65	93	-can	-can	PUNCT
gsrj-12	65	94	target	target	VERB
gsrj-12	65	95	specific	specific	ADJ
gsrj-12	65	96	locations	location	NOUN
gsrj-12	65	97	tariquidar	tariquidar	VERB
gsrj-12	65	98	105	105	NUM
gsrj-12	65	99	georgetown	georgetown	PROPN
gsrj-12	65	100	scientific	scientific	PROPN
gsrj-12	65	101	research	research	NOUN
gsrj-12	65	102	journal	journal	PROPN
gsrj-12	65	103	https://doi.org/10.48091/uwyg8998	https://doi.org/10.48091/uwyg8998	NOUN
gsrj-12	65	104	three	three	NUM
gsrj-12	65	105	distinct	distinct	ADJ
gsrj-12	65	106	generations	generation	NOUN
gsrj-12	65	107	of	of	ADP
gsrj-12	65	108	pgp	pgp	NOUN
gsrj-12	65	109	inhibitors	inhibitor	NOUN
gsrj-12	65	110	that	that	PRON
gsrj-12	65	111	perform	perform	VERB
gsrj-12	65	112	similar	similar	ADJ
gsrj-12	65	113	functions	function	NOUN
gsrj-12	65	114	have	have	AUX
gsrj-12	65	115	been	be	AUX
gsrj-12	65	116	identified	identify	VERB
gsrj-12	65	117	(	(	PUNCT
gsrj-12	65	118	table	table	NOUN
gsrj-12	65	119	1	1	NUM
gsrj-12	65	120	)	)	PUNCT
gsrj-12	65	121	.	.	PUNCT
gsrj-12	66	1	first	first	ADJ
gsrj-12	66	2	-	-	PUNCT
gsrj-12	66	3	generation	generation	NOUN
gsrj-12	66	4	inhibitors	inhibitor	NOUN
gsrj-12	66	5	are	be	AUX
gsrj-12	66	6	substances	substance	NOUN
gsrj-12	66	7	originally	originally	ADV
gsrj-12	66	8	developed	develop	VERB
gsrj-12	66	9	to	to	PART
gsrj-12	66	10	treat	treat	VERB
gsrj-12	66	11	other	other	ADJ
gsrj-12	66	12	conditions	condition	NOUN
gsrj-12	66	13	that	that	PRON
gsrj-12	66	14	were	be	AUX
gsrj-12	66	15	found	find	VERB
gsrj-12	66	16	to	to	PART
gsrj-12	66	17	also	also	ADV
gsrj-12	66	18	successfully	successfully	ADV
gsrj-12	66	19	inhibit	inhibit	VERB
gsrj-12	66	20	p	p	NOUN
gsrj-12	66	21	-	-	PUNCT
gsrj-12	66	22	gps	gps	NOUN
gsrj-12	66	23	.	.	PUNCT
gsrj-12	67	1	first	first	ADJ
gsrj-12	67	2	generation	generation	NOUN
gsrj-12	67	3	inhibitors	inhibitor	NOUN
gsrj-12	67	4	are	be	AUX
gsrj-12	67	5	the	the	DET
gsrj-12	67	6	most	most	ADV
gsrj-12	67	7	pharmacologically	pharmacologically	ADV
gsrj-12	67	8	active	active	ADJ
gsrj-12	67	9	,	,	PUNCT
gsrj-12	67	10	but	but	CCONJ
gsrj-12	67	11	they	they	PRON
gsrj-12	67	12	pose	pose	VERB
gsrj-12	67	13	potential	potential	ADJ
gsrj-12	67	14	limitations	limitation	NOUN
gsrj-12	67	15	in	in	ADP
gsrj-12	67	16	dosage	dosage	NOUN
gsrj-12	67	17	due	due	ADP
gsrj-12	67	18	to	to	ADP
gsrj-12	67	19	their	their	PRON
gsrj-12	67	20	latent	latent	NOUN
gsrj-12	67	21	toxicity	toxicity	NOUN
gsrj-12	67	22	,	,	PUNCT
gsrj-12	67	23	unusually	unusually	ADV
gsrj-12	67	24	high	high	ADJ
gsrj-12	67	25	serum	serum	NOUN
gsrj-12	67	26	concentrations	concentration	NOUN
gsrj-12	67	27	,	,	PUNCT
gsrj-12	67	28	and	and	CCONJ
gsrj-12	67	29	ability	ability	NOUN
gsrj-12	67	30	to	to	PART
gsrj-12	67	31	substrate	substrate	VERB
gsrj-12	67	32	with	with	ADP
gsrj-12	67	33	a	a	DET
gsrj-12	67	34	wide	wide	ADJ
gsrj-12	67	35	range	range	NOUN
gsrj-12	67	36	of	of	ADP
gsrj-12	67	37	unintended	unintended	ADJ
gsrj-12	67	38	,	,	PUNCT
gsrj-12	67	39	biologically	biologically	ADV
gsrj-12	67	40	beneficial	beneficial	ADJ
gsrj-12	67	41	transporters	transporter	NOUN
gsrj-12	67	42	and	and	CCONJ
gsrj-12	67	43	enzymes.16	enzymes.16	NOUN
gsrj-12	67	44	second	second	ADJ
gsrj-12	67	45	-	-	PUNCT
gsrj-12	67	46	generation	generation	NOUN
gsrj-12	67	47	inhibitors	inhibitor	NOUN
gsrj-12	67	48	do	do	AUX
gsrj-12	67	49	not	not	PART
gsrj-12	67	50	hold	hold	VERB
gsrj-12	67	51	the	the	DET
gsrj-12	67	52	same	same	ADJ
gsrj-12	67	53	range	range	NOUN
gsrj-12	67	54	of	of	ADP
gsrj-12	67	55	pharmacological	pharmacological	ADJ
gsrj-12	67	56	ability	ability	NOUN
gsrj-12	67	57	as	as	ADP
gsrj-12	67	58	the	the	DET
gsrj-12	67	59	first	first	ADJ
gsrj-12	67	60	-	-	PUNCT
gsrj-12	67	61	generation	generation	NOUN
gsrj-12	67	62	,	,	PUNCT
gsrj-12	67	63	but	but	CCONJ
gsrj-12	67	64	they	they	PRON
gsrj-12	67	65	do	do	AUX
gsrj-12	67	66	possess	possess	VERB
gsrj-12	67	67	a	a	DET
gsrj-12	67	68	greater	great	ADJ
gsrj-12	67	69	affinity	affinity	NOUN
gsrj-12	67	70	for	for	ADP
gsrj-12	67	71	p	p	NOUN
gsrj-12	67	72	-	-	PUNCT
gsrj-12	67	73	gps	gps	NOUN
gsrj-12	67	74	,	,	PUNCT
gsrj-12	67	75	allowing	allow	VERB
gsrj-12	67	76	for	for	ADP
gsrj-12	67	77	more	more	ADV
gsrj-12	67	78	specific	specific	ADJ
gsrj-12	67	79	targeting	targeting	NOUN
gsrj-12	67	80	in	in	ADP
gsrj-12	67	81	the	the	DET
gsrj-12	67	82	body	body	NOUN
gsrj-12	67	83	.	.	PUNCT
gsrj-12	68	1	however	however	ADV
gsrj-12	68	2	,	,	PUNCT
gsrj-12	68	3	second	second	ADJ
gsrj-12	68	4	-	-	PUNCT
gsrj-12	68	5	generation	generation	NOUN
gsrj-12	68	6	inhibitors	inhibitor	NOUN
gsrj-12	68	7	are	be	AUX
gsrj-12	68	8	limited	limit	VERB
gsrj-12	68	9	in	in	ADP
gsrj-12	68	10	clinical	clinical	ADJ
gsrj-12	68	11	use	use	NOUN
gsrj-12	68	12	by	by	ADP
gsrj-12	68	13	their	their	PRON
gsrj-12	68	14	tendency	tendency	NOUN
gsrj-12	68	15	to	to	PART
gsrj-12	68	16	inhibit	inhibit	VERB
gsrj-12	68	17	certain	certain	ADJ
gsrj-12	68	18	enzymatic	enzymatic	ADJ
gsrj-12	68	19	activities	activity	NOUN
gsrj-12	68	20	and	and	CCONJ
gsrj-12	68	21	other	other	ADJ
gsrj-12	68	22	abc	abc	PROPN
gsrj-12	68	23	transporters	transporter	NOUN
gsrj-12	68	24	that	that	PRON
gsrj-12	68	25	lead	lead	VERB
gsrj-12	68	26	to	to	ADP
gsrj-12	68	27	complicated	complicated	ADJ
gsrj-12	68	28	drug	drug	NOUN
gsrj-12	68	29	-	-	PUNCT
gsrj-12	68	30	drug	drug	NOUN
gsrj-12	68	31	interactions.16	interactions.16	ADJ
gsrj-12	68	32	  	  	SPACE
gsrj-12	68	33	most	most	ADJ
gsrj-12	68	34	third	third	ADJ
gsrj-12	68	35	-	-	PUNCT
gsrj-12	68	36	generation	generation	NOUN
gsrj-12	68	37	inhibitors	inhibitor	NOUN
gsrj-12	68	38	are	be	AUX
gsrj-12	68	39	still	still	ADV
gsrj-12	68	40	in	in	ADP
gsrj-12	68	41	the	the	DET
gsrj-12	68	42	clinical	clinical	ADJ
gsrj-12	68	43	development	development	NOUN
gsrj-12	68	44	phase	phase	NOUN
gsrj-12	68	45	and	and	CCONJ
gsrj-12	68	46	aim	aim	VERB
gsrj-12	68	47	to	to	PART
gsrj-12	68	48	act	act	VERB
gsrj-12	68	49	with	with	ADP
gsrj-12	68	50	high	high	ADJ
gsrj-12	68	51	p	p	NOUN
gsrj-12	68	52	-	-	PUNCT
gsrj-12	68	53	gp	gp	NOUN
gsrj-12	68	54	specificity	specificity	NOUN
gsrj-12	68	55	and	and	CCONJ
gsrj-12	68	56	low	low	ADJ
gsrj-12	68	57	toxicity	toxicity	NOUN
gsrj-12	68	58	.	.	PUNCT
gsrj-12	69	1	while	while	SCONJ
gsrj-12	69	2	all	all	DET
gsrj-12	69	3	three	three	NUM
gsrj-12	69	4	generations	generation	NOUN
gsrj-12	69	5	of	of	ADP
gsrj-12	69	6	p	p	NOUN
gsrj-12	69	7	-	-	PUNCT
gsrj-12	69	8	gp	gp	NOUN
gsrj-12	69	9	inhibitors	inhibitor	NOUN
gsrj-12	69	10	face	face	VERB
gsrj-12	69	11	potential	potential	ADJ
gsrj-12	69	12	restrictions	restriction	NOUN
gsrj-12	69	13	in	in	ADP
gsrj-12	69	14	their	their	PRON
gsrj-12	69	15	use	use	NOUN
gsrj-12	69	16	,	,	PUNCT
gsrj-12	69	17	they	they	PRON
gsrj-12	69	18	also	also	ADV
gsrj-12	69	19	offer	offer	VERB
gsrj-12	69	20	promising	promise	VERB
gsrj-12	69	21	properties	property	NOUN
gsrj-12	69	22	as	as	ADP
gsrj-12	69	23	a	a	DET
gsrj-12	69	24	clinical	clinical	ADJ
gsrj-12	69	25	treatment	treatment	NOUN
gsrj-12	69	26	for	for	ADP
gsrj-12	69	27	refractory	refractory	NOUN
gsrj-12	69	28	epilepsy	epilepsy	NOUN
gsrj-12	69	29	.	.	PUNCT
gsrj-12	69	30	  	  	SPACE
gsrj-12	70	1	4.2	4.2	NUM
gsrj-12	70	2	tariquidar	tariquidar	NOUN
gsrj-12	70	3	as	as	ADP
gsrj-12	70	4	a	a	DET
gsrj-12	70	5	promising	promising	ADJ
gsrj-12	70	6	therapeutic	therapeutic	ADJ
gsrj-12	70	7	option	option	NOUN
gsrj-12	70	8	in	in	ADP
gsrj-12	70	9	identifying	identify	VERB
gsrj-12	70	10	p	p	NOUN
gsrj-12	70	11	-	-	PUNCT
gsrj-12	70	12	gp	gp	NOUN
gsrj-12	70	13	inhibition	inhibition	NOUN
gsrj-12	70	14	as	as	ADP
gsrj-12	70	15	a	a	DET
gsrj-12	70	16	potential	potential	ADJ
gsrj-12	70	17	therapeutic	therapeutic	ADJ
gsrj-12	70	18	option	option	NOUN
gsrj-12	70	19	for	for	ADP
gsrj-12	70	20	refractory	refractory	NOUN
gsrj-12	70	21	epilepsy	epilepsy	NOUN
gsrj-12	70	22	,	,	PUNCT
gsrj-12	70	23	it	it	PRON
gsrj-12	70	24	is	be	AUX
gsrj-12	70	25	important	important	ADJ
gsrj-12	70	26	to	to	PART
gsrj-12	70	27	consider	consider	VERB
gsrj-12	70	28	the	the	DET
gsrj-12	70	29	specific	specific	ADJ
gsrj-12	70	30	functions	function	NOUN
gsrj-12	70	31	and	and	CCONJ
gsrj-12	70	32	locations	location	NOUN
gsrj-12	70	33	of	of	ADP
gsrj-12	70	34	these	these	DET
gsrj-12	70	35	inhibitors	inhibitor	NOUN
gsrj-12	70	36	.	.	PUNCT
gsrj-12	71	1	p	p	X
gsrj-12	71	2	-	-	PUNCT
gsrj-12	71	3	gp	gp	NOUN
gsrj-12	71	4	inhibitors	inhibitor	NOUN
gsrj-12	71	5	may	may	AUX
gsrj-12	71	6	specifically	specifically	ADV
gsrj-12	71	7	target	target	VERB
gsrj-12	71	8	overexpression	overexpression	NOUN
gsrj-12	71	9	in	in	ADP
gsrj-12	71	10	the	the	DET
gsrj-12	71	11	intestines	intestine	NOUN
gsrj-12	71	12	,	,	PUNCT
gsrj-12	71	13	liver	liver	NOUN
gsrj-12	71	14	,	,	PUNCT
gsrj-12	71	15	brain	brain	NOUN
gsrj-12	71	16	,	,	PUNCT
gsrj-12	71	17	and	and	CCONJ
gsrj-12	71	18	kidneys	kidney	NOUN
gsrj-12	71	19	or	or	CCONJ
gsrj-12	71	20	may	may	AUX
gsrj-12	71	21	only	only	ADV
gsrj-12	71	22	play	play	VERB
gsrj-12	71	23	a	a	DET
gsrj-12	71	24	pharmacological	pharmacological	ADJ
gsrj-12	71	25	role	role	NOUN
gsrj-12	71	26	in	in	ADP
gsrj-12	71	27	increasing	increase	VERB
gsrj-12	71	28	the	the	DET
gsrj-12	71	29	uptake	uptake	NOUN
gsrj-12	71	30	of	of	ADP
gsrj-12	71	31	certain	certain	ADJ
gsrj-12	71	32	drugs.17	drugs.17	PROPN
gsrj-12	71	33	two	two	NUM
gsrj-12	71	34	such	such	ADJ
gsrj-12	71	35	pgp	pgp	NOUN
gsrj-12	71	36	inhibitors	inhibitor	NOUN
gsrj-12	71	37	,	,	PUNCT
gsrj-12	71	38	tariquidar	tariquidar	PRON
gsrj-12	71	39	(	(	PUNCT
gsrj-12	71	40	tqd	tqd	NOUN
gsrj-12	71	41	)	)	PUNCT
gsrj-12	71	42	and	and	CCONJ
gsrj-12	71	43	verapamil	verapamil	NOUN
gsrj-12	71	44	,	,	PUNCT
gsrj-12	71	45	have	have	AUX
gsrj-12	71	46	been	be	AUX
gsrj-12	71	47	identified	identify	VERB
gsrj-12	71	48	as	as	ADP
gsrj-12	71	49	potential	potential	ADJ
gsrj-12	71	50	treatments	treatment	NOUN
gsrj-12	71	51	for	for	ADP
gsrj-12	71	52	refractory	refractory	NOUN
gsrj-12	71	53	epilepsy	epilepsy	NOUN
gsrj-12	71	54	due	due	ADP
gsrj-12	71	55	to	to	ADP
gsrj-12	71	56	their	their	PRON
gsrj-12	71	57	high	high	ADJ
gsrj-12	71	58	specificity	specificity	NOUN
gsrj-12	71	59	in	in	ADP
gsrj-12	71	60	targeting	target	VERB
gsrj-12	71	61	the	the	DET
gsrj-12	71	62	blood	blood	NOUN
gsrj-12	71	63	brain	brain	NOUN
gsrj-12	71	64	barrier	barrier	NOUN
gsrj-12	71	65	.	.	PUNCT
gsrj-12	72	1	many	many	ADJ
gsrj-12	72	2	studies	study	NOUN
gsrj-12	72	3	have	have	AUX
gsrj-12	72	4	provided	provide	VERB
gsrj-12	72	5	evidence	evidence	NOUN
gsrj-12	72	6	to	to	PART
gsrj-12	72	7	indicate	indicate	VERB
gsrj-12	72	8	that	that	SCONJ
gsrj-12	72	9	tariquidar	tariquidar	NOUN
gsrj-12	72	10	,	,	PUNCT
gsrj-12	72	11	or	or	CCONJ
gsrj-12	72	12	tqd	tqd	NOUN
gsrj-12	72	13	,	,	PUNCT
gsrj-12	72	14	is	be	AUX
gsrj-12	72	15	a	a	DET
gsrj-12	72	16	promising	promising	ADJ
gsrj-12	72	17	selective	selective	ADJ
gsrj-12	72	18	inhibitor	inhibitor	NOUN
gsrj-12	72	19	of	of	ADP
gsrj-12	72	20	p	p	NOUN
gsrj-12	72	21	-	-	PUNCT
gsrj-12	72	22	gp	gp	NOUN
gsrj-12	72	23	that	that	PRON
gsrj-12	72	24	may	may	AUX
gsrj-12	72	25	offer	offer	VERB
gsrj-12	72	26	a	a	DET
gsrj-12	72	27	solution	solution	NOUN
gsrj-12	72	28	to	to	ADP
gsrj-12	72	29	refractory	refractory	NOUN
gsrj-12	72	30	epilepsy	epilepsy	NOUN
gsrj-12	72	31	.	.	PUNCT
gsrj-12	73	1	as	as	SCONJ
gsrj-12	73	2	previously	previously	ADV
gsrj-12	73	3	tested	test	VERB
gsrj-12	73	4	by	by	ADP
gsrj-12	73	5	van	van	PROPN
gsrj-12	73	6	vliet	vliet	PROPN
gsrj-12	73	7	,	,	PUNCT
gsrj-12	73	8	e.	e.	PROPN
gsrj-12	73	9	a.	a.	PROPN
gsrj-12	73	10	et	et	PROPN
gsrj-12	73	11	al	al	PROPN
gsrj-12	73	12	.	.	PROPN
gsrj-12	73	13	,	,	PUNCT
gsrj-12	73	14	tqd	tqd	PROPN
gsrj-12	73	15	shows	show	VERB
gsrj-12	73	16	great	great	ADJ
gsrj-12	73	17	potential	potential	NOUN
gsrj-12	73	18	in	in	ADP
gsrj-12	73	19	counteracting	counteract	VERB
gsrj-12	73	20	pharmacoresistance	pharmacoresistance	NOUN
gsrj-12	73	21	of	of	ADP
gsrj-12	73	22	aeds	aed	NOUN
gsrj-12	73	23	resulting	result	VERB
gsrj-12	73	24	from	from	ADP
gsrj-12	73	25	the	the	DET
gsrj-12	73	26	overexpression	overexpression	NOUN
gsrj-12	73	27	of	of	ADP
gsrj-12	73	28	pgps.15	pgps.15	PROPN
gsrj-12	73	29	tqd	tqd	PROPN
gsrj-12	73	30	is	be	AUX
gsrj-12	73	31	a	a	DET
gsrj-12	73	32	third	third	ADJ
gsrj-12	73	33	-	-	PUNCT
gsrj-12	73	34	generation	generation	NOUN
gsrj-12	73	35	p	p	NOUN
gsrj-12	73	36	-	-	PUNCT
gsrj-12	73	37	gp	gp	NOUN
gsrj-12	73	38	inhibitor	inhibitor	NOUN
gsrj-12	73	39	known	know	VERB
gsrj-12	73	40	for	for	ADP
gsrj-12	73	41	its	its	PRON
gsrj-12	73	42	high	high	ADJ
gsrj-12	73	43	selectivity	selectivity	NOUN
gsrj-12	73	44	,	,	PUNCT
gsrj-12	73	45	long	long	ADV
gsrj-12	73	46	active	active	ADJ
gsrj-12	73	47	period	period	NOUN
gsrj-12	73	48	,	,	PUNCT
gsrj-12	73	49	and	and	CCONJ
gsrj-12	73	50	advantageous	advantageous	ADJ
gsrj-12	73	51	oral	oral	ADJ
gsrj-12	73	52	administration	administration	NOUN
gsrj-12	73	53	and	and	CCONJ
gsrj-12	73	54	bioavailability.17	bioavailability.17	PROPN
gsrj-12	73	55	since	since	SCONJ
gsrj-12	73	56	its	its	PRON
gsrj-12	73	57	development	development	NOUN
gsrj-12	73	58	,	,	PUNCT
gsrj-12	73	59	this	this	DET
gsrj-12	73	60	exceptionally	exceptionally	ADV
gsrj-12	73	61	potent	potent	ADJ
gsrj-12	73	62	inhibitor	inhibitor	NOUN
gsrj-12	73	63	has	have	AUX
gsrj-12	73	64	been	be	AUX
gsrj-12	73	65	considered	consider	VERB
gsrj-12	73	66	one	one	NUM
gsrj-12	73	67	of	of	ADP
gsrj-12	73	68	the	the	DET
gsrj-12	73	69	best	good	ADJ
gsrj-12	73	70	ways	way	NOUN
gsrj-12	73	71	to	to	PART
gsrj-12	73	72	reduce	reduce	VERB
gsrj-12	73	73	the	the	DET
gsrj-12	73	74	effects	effect	NOUN
gsrj-12	73	75	of	of	ADP
gsrj-12	73	76	pgp	pgp	NOUN
gsrj-12	73	77	overexpression	overexpression	NOUN
gsrj-12	73	78	.	.	PUNCT
gsrj-12	74	1	the	the	DET
gsrj-12	74	2	oral	oral	ADJ
gsrj-12	74	3	intake	intake	NOUN
gsrj-12	74	4	of	of	ADP
gsrj-12	74	5	drugs	drug	NOUN
gsrj-12	74	6	such	such	ADJ
gsrj-12	74	7	as	as	ADP
gsrj-12	74	8	tqd	tqd	PROPN
gsrj-12	74	9	is	be	AUX
gsrj-12	74	10	often	often	ADV
gsrj-12	74	11	the	the	DET
gsrj-12	74	12	most	most	ADV
gsrj-12	74	13	convenient	convenient	ADJ
gsrj-12	74	14	and	and	CCONJ
gsrj-12	74	15	safest	safe	ADJ
gsrj-12	74	16	route	route	NOUN
gsrj-12	74	17	of	of	ADP
gsrj-12	74	18	drug	drug	NOUN
gsrj-12	74	19	administration	administration	NOUN
gsrj-12	74	20	and	and	CCONJ
gsrj-12	74	21	,	,	PUNCT
gsrj-12	74	22	following	follow	VERB
gsrj-12	74	23	the	the	DET
gsrj-12	74	24	administration	administration	NOUN
gsrj-12	74	25	of	of	ADP
gsrj-12	74	26	tqd	tqd	PROPN
gsrj-12	74	27	specifically	specifically	ADV
gsrj-12	74	28	,	,	PUNCT
gsrj-12	74	29	has	have	AUX
gsrj-12	74	30	shown	show	VERB
gsrj-12	74	31	to	to	PART
gsrj-12	74	32	have	have	VERB
gsrj-12	74	33	a	a	DET
gsrj-12	74	34	relatively	relatively	ADV
gsrj-12	74	35	strong	strong	ADJ
gsrj-12	74	36	bioavailability	bioavailability	NOUN
gsrj-12	74	37	.	.	PUNCT
gsrj-12	75	1	tqd	tqd	PROPN
gsrj-12	75	2	also	also	ADV
gsrj-12	75	3	acts	act	VERB
gsrj-12	75	4	as	as	ADP
gsrj-12	75	5	a	a	DET
gsrj-12	75	6	non	non	ADJ
gsrj-12	75	7	-	-	ADJ
gsrj-12	75	8	competitive	competitive	ADJ
gsrj-12	75	9	inhibitor	inhibitor	NOUN
gsrj-12	75	10	to	to	PART
gsrj-12	75	11	reduce	reduce	VERB
gsrj-12	75	12	the	the	DET
gsrj-12	75	13	atp	atp	NOUN
gsrj-12	75	14	hydrolyzing	hydrolyze	VERB
gsrj-12	75	15	activity	activity	NOUN
gsrj-12	75	16	of	of	ADP
gsrj-12	75	17	p	p	NOUN
gsrj-12	75	18	-	-	PUNCT
gsrj-12	75	19	gps	gps	NOUN
gsrj-12	75	20	.	.	PUNCT
gsrj-12	76	1	this	this	DET
gsrj-12	76	2	activity	activity	NOUN
gsrj-12	76	3	facilitates	facilitate	VERB
gsrj-12	76	4	the	the	DET
gsrj-12	76	5	transport	transport	NOUN
gsrj-12	76	6	of	of	ADP
gsrj-12	76	7	substances	substance	NOUN
gsrj-12	76	8	out	out	ADP
gsrj-12	76	9	of	of	ADP
gsrj-12	76	10	cells	cell	NOUN
gsrj-12	76	11	;	;	PUNCT
gsrj-12	76	12	thus	thus	ADV
gsrj-12	76	13	,	,	PUNCT
gsrj-12	76	14	tqd	tqd	PROPN
gsrj-12	76	15	inhibits	inhibit	VERB
gsrj-12	76	16	such	such	ADJ
gsrj-12	76	17	behavior	behavior	NOUN
gsrj-12	76	18	that	that	PRON
gsrj-12	76	19	is	be	AUX
gsrj-12	76	20	key	key	ADJ
gsrj-12	76	21	to	to	PART
gsrj-12	76	22	pharmacoresistance.17	pharmacoresistance.17	VERB
gsrj-12	76	23	one	one	NUM
gsrj-12	76	24	study	study	NOUN
gsrj-12	76	25	demonstrated	demonstrate	VERB
gsrj-12	76	26	the	the	DET
gsrj-12	76	27	high	high	ADJ
gsrj-12	76	28	potency	potency	NOUN
gsrj-12	76	29	of	of	ADP
gsrj-12	76	30	tqd	tqd	NOUN
gsrj-12	76	31	as	as	ADP
gsrj-12	76	32	a	a	DET
gsrj-12	76	33	p	p	NOUN
gsrj-12	76	34	-	-	PUNCT
gsrj-12	76	35	gp	gp	NOUN
gsrj-12	76	36	inhibitor	inhibitor	NOUN
gsrj-12	76	37	and	and	CCONJ
gsrj-12	76	38	discovered	discover	VERB
gsrj-12	76	39	that	that	SCONJ
gsrj-12	76	40	the	the	DET
gsrj-12	76	41	administration	administration	NOUN
gsrj-12	76	42	of	of	ADP
gsrj-12	76	43	one	one	NUM
gsrj-12	76	44	micromolar	micromolar	NOUN
gsrj-12	76	45	of	of	ADP
gsrj-12	76	46	tqd	tqd	PROPN
gsrj-12	76	47	decreased	decrease	VERB
gsrj-12	76	48	the	the	DET
gsrj-12	76	49	atpase	atpase	PROPN
gsrj-12	76	50	activity	activity	NOUN
gsrj-12	76	51	of	of	ADP
gsrj-12	76	52	p	p	NOUN
gsrj-12	76	53	-	-	PUNCT
gsrj-12	76	54	gp	gp	NOUN
gsrj-12	76	55	by	by	ADP
gsrj-12	76	56	over	over	ADP
gsrj-12	76	57	50%.18	50%.18	NUM
gsrj-12	76	58	while	while	SCONJ
gsrj-12	76	59	tqd	tqd	PROPN
gsrj-12	76	60	has	have	AUX
gsrj-12	76	61	mainly	mainly	ADV
gsrj-12	76	62	been	be	AUX
gsrj-12	76	63	studied	study	VERB
gsrj-12	76	64	as	as	ADP
gsrj-12	76	65	a	a	DET
gsrj-12	76	66	modulator	modulator	NOUN
gsrj-12	76	67	of	of	ADP
gsrj-12	76	68	reversing	reverse	VERB
gsrj-12	76	69	multidrug	multidrug	NOUN
gsrj-12	76	70	resistance	resistance	NOUN
gsrj-12	76	71	in	in	ADP
gsrj-12	76	72	cancer	cancer	NOUN
gsrj-12	76	73	,	,	PUNCT
gsrj-12	76	74	current	current	ADJ
gsrj-12	76	75	evidence	evidence	NOUN
gsrj-12	76	76	has	have	AUX
gsrj-12	76	77	also	also	ADV
gsrj-12	76	78	identified	identify	VERB
gsrj-12	76	79	tqd	tqd	NOUN
gsrj-12	76	80	as	as	ADP
gsrj-12	76	81	a	a	DET
gsrj-12	76	82	potential	potential	ADJ
gsrj-12	76	83	modulator	modulator	NOUN
gsrj-12	76	84	of	of	ADP
gsrj-12	76	85	pharmacoresistance	pharmacoresistance	NOUN
gsrj-12	76	86	in	in	ADP
gsrj-12	76	87	epilepsy.12	epilepsy.12	NOUN
gsrj-12	76	88	many	many	ADJ
gsrj-12	76	89	studies	study	NOUN
gsrj-12	76	90	have	have	AUX
gsrj-12	76	91	demonstrated	demonstrate	VERB
gsrj-12	76	92	the	the	DET
gsrj-12	76	93	inhibitory	inhibitory	ADJ
gsrj-12	76	94	effect	effect	NOUN
gsrj-12	76	95	of	of	ADP
gsrj-12	76	96	tqd	tqd	NOUN
gsrj-12	76	97	on	on	ADP
gsrj-12	76	98	p	p	NOUN
gsrj-12	76	99	-	-	PUNCT
gsrj-12	76	100	gp	gp	NOUN
gsrj-12	76	101	overexpression	overexpression	NOUN
gsrj-12	76	102	that	that	PRON
gsrj-12	76	103	contributes	contribute	VERB
gsrj-12	76	104	to	to	ADP
gsrj-12	76	105	refractory	refractory	NOUN
gsrj-12	76	106	epilepsy	epilepsy	NOUN
gsrj-12	76	107	.	.	PUNCT
gsrj-12	77	1	building	build	VERB
gsrj-12	77	2	upon	upon	SCONJ
gsrj-12	77	3	their	their	PRON
gsrj-12	77	4	previous	previous	ADJ
gsrj-12	77	5	work	work	NOUN
gsrj-12	77	6	measuring	measure	VERB
gsrj-12	77	7	aed	aed	NOUN
gsrj-12	77	8	uptake	uptake	NOUN
gsrj-12	77	9	in	in	ADP
gsrj-12	77	10	brain	brain	NOUN
gsrj-12	77	11	regions	region	NOUN
gsrj-12	77	12	with	with	ADP
gsrj-12	77	13	p	p	NOUN
gsrj-12	77	14	-	-	PUNCT
gsrj-12	77	15	gp	gp	NOUN
gsrj-12	77	16	overexpression	overexpression	NOUN
gsrj-12	77	17	,	,	PUNCT
gsrj-12	77	18	van	van	PROPN
gsrj-12	77	19	vliet	vliet	PROPN
gsrj-12	77	20	,	,	PUNCT
gsrj-12	78	1	e.	e.	PROPN
gsrj-12	78	2	a.	a.	PROPN
gsrj-12	78	3	et	et	PROPN
gsrj-12	78	4	al	al	PROPN
gsrj-12	78	5	.	.	PROPN
gsrj-12	78	6	continued	continue	VERB
gsrj-12	78	7	an	an	DET
gsrj-12	78	8	investigation	investigation	NOUN
gsrj-12	78	9	into	into	ADP
gsrj-12	78	10	the	the	DET
gsrj-12	78	11	anticonvulsant	anticonvulsant	ADJ
gsrj-12	78	12	effects	effect	NOUN
gsrj-12	78	13	of	of	ADP
gsrj-12	78	14	phenytoin	phenytoin	NOUN
gsrj-12	78	15	(	(	PUNCT
gsrj-12	78	16	pht	pht	PROPN
gsrj-12	78	17	)	)	PUNCT
gsrj-12	78	18	before	before	ADP
gsrj-12	78	19	and	and	CCONJ
gsrj-12	78	20	after	after	ADP
gsrj-12	78	21	administration	administration	NOUN
gsrj-12	78	22	of	of	ADP
gsrj-12	78	23	tqd	tqd	PROPN
gsrj-12	78	24	.	.	PUNCT
gsrj-12	79	1	after	after	ADP
gsrj-12	79	2	coadministering	coadministere	VERB
gsrj-12	79	3	pht	pht	PROPN
gsrj-12	79	4	and	and	CCONJ
gsrj-12	79	5	tqd	tqd	VERB
gsrj-12	79	6	to	to	ADP
gsrj-12	79	7	rats	rat	NOUN
gsrj-12	79	8	with	with	ADP
gsrj-12	79	9	frequent	frequent	ADJ
gsrj-12	79	10	daily	daily	ADJ
gsrj-12	79	11	seizures	seizure	NOUN
gsrj-12	79	12	,	,	PUNCT
gsrj-12	79	13	researchers	researcher	NOUN
gsrj-12	79	14	analyzed	analyze	VERB
gsrj-12	79	15	brainto	brainto	NOUN
gsrj-12	79	16	-	-	PUNCT
gsrj-12	79	17	plasma	plasma	NOUN
gsrj-12	79	18	concentration	concentration	NOUN
gsrj-12	79	19	ratio	ratio	NOUN
gsrj-12	79	20	measurements	measurement	NOUN
gsrj-12	79	21	of	of	ADP
gsrj-12	79	22	pht.19	pht.19	NOUN
gsrj-12	79	23	the	the	DET
gsrj-12	79	24	researchers	researcher	NOUN
gsrj-12	79	25	also	also	ADV
gsrj-12	79	26	recorded	record	VERB
gsrj-12	79	27	the	the	DET
gsrj-12	79	28	frequency	frequency	NOUN
gsrj-12	79	29	of	of	ADP
gsrj-12	79	30	seizures	seizure	NOUN
gsrj-12	79	31	to	to	PART
gsrj-12	79	32	determine	determine	VERB
gsrj-12	79	33	any	any	DET
gsrj-12	79	34	observable	observable	ADJ
gsrj-12	79	35	changes	change	NOUN
gsrj-12	79	36	in	in	ADP
gsrj-12	79	37	the	the	DET
gsrj-12	79	38	epileptic	epileptic	ADJ
gsrj-12	79	39	activity	activity	NOUN
gsrj-12	79	40	of	of	ADP
gsrj-12	79	41	the	the	DET
gsrj-12	79	42	rats	rat	NOUN
gsrj-12	79	43	when	when	SCONJ
gsrj-12	79	44	treated	treat	VERB
gsrj-12	79	45	with	with	ADP
gsrj-12	79	46	tqd	tqd	PROPN
gsrj-12	79	47	.	.	PUNCT
gsrj-12	80	1	the	the	DET
gsrj-12	80	2	results	result	NOUN
gsrj-12	80	3	showed	show	VERB
gsrj-12	80	4	that	that	SCONJ
gsrj-12	80	5	,	,	PUNCT
gsrj-12	80	6	when	when	SCONJ
gsrj-12	80	7	combined	combine	VERB
gsrj-12	80	8	with	with	ADP
gsrj-12	80	9	tqd	tqd	PROPN
gsrj-12	80	10	,	,	PUNCT
gsrj-12	80	11	pht	pht	PROPN
gsrj-12	80	12	levels	level	NOUN
gsrj-12	80	13	in	in	ADP
gsrj-12	80	14	the	the	DET
gsrj-12	80	15	rats	rat	NOUN
gsrj-12	80	16	remained	remain	VERB
gsrj-12	80	17	within	within	ADP
gsrj-12	80	18	the	the	DET
gsrj-12	80	19	therapeutic	therapeutic	ADJ
gsrj-12	80	20	range	range	NOUN
gsrj-12	80	21	in	in	ADP
gsrj-12	80	22	the	the	DET
gsrj-12	80	23	blood	blood	NOUN
gsrj-12	80	24	for	for	ADP
gsrj-12	80	25	an	an	DET
gsrj-12	80	26	additional	additional	ADJ
gsrj-12	80	27	8	8	NUM
gsrj-12	80	28	hours	hour	NOUN
gsrj-12	80	29	compared	compare	VERB
gsrj-12	80	30	to	to	PART
gsrj-12	80	31	pht	pht	VERB
gsrj-12	80	32	alone	alone	ADV
gsrj-12	80	33	.	.	PUNCT
gsrj-12	81	1	106	106	NUM
gsrj-12	81	2	georgetown	georgetown	PROPN
gsrj-12	81	3	scientific	scientific	PROPN
gsrj-12	81	4	research	research	NOUN
gsrj-12	81	5	journal	journal	NOUN
gsrj-12	81	6	https://doi.org/10.48091/uwyg8998	https://doi.org/10.48091/uwyg8998	PROPN
gsrj-12	81	7	additionally	additionally	ADV
gsrj-12	81	8	,	,	PUNCT
gsrj-12	81	9	overall	overall	ADJ
gsrj-12	81	10	seizure	seizure	NOUN
gsrj-12	81	11	activity	activity	NOUN
gsrj-12	81	12	was	be	AUX
gsrj-12	81	13	reduced	reduce	VERB
gsrj-12	81	14	in	in	ADP
gsrj-12	81	15	rats	rat	NOUN
gsrj-12	81	16	treated	treat	VERB
gsrj-12	81	17	with	with	ADP
gsrj-12	81	18	both	both	DET
gsrj-12	81	19	drugs	drug	NOUN
gsrj-12	81	20	.	.	PUNCT
gsrj-12	82	1	in	in	ADP
gsrj-12	82	2	the	the	DET
gsrj-12	82	3	control	control	NOUN
gsrj-12	82	4	group	group	NOUN
gsrj-12	82	5	,	,	PUNCT
gsrj-12	82	6	pht	pht	PROPN
gsrj-12	82	7	treatment	treatment	NOUN
gsrj-12	82	8	alone	alone	ADV
gsrj-12	82	9	did	do	AUX
gsrj-12	82	10	not	not	PART
gsrj-12	82	11	significantly	significantly	ADV
gsrj-12	82	12	decrease	decrease	VERB
gsrj-12	82	13	seizure	seizure	NOUN
gsrj-12	82	14	activity	activity	NOUN
gsrj-12	82	15	until	until	ADP
gsrj-12	82	16	day	day	NOUN
gsrj-12	82	17	13	13	NUM
gsrj-12	82	18	.	.	PUNCT
gsrj-12	83	1	conversely	conversely	ADV
gsrj-12	83	2	,	,	PUNCT
gsrj-12	83	3	the	the	DET
gsrj-12	83	4	experimental	experimental	ADJ
gsrj-12	83	5	group	group	NOUN
gsrj-12	83	6	of	of	ADP
gsrj-12	83	7	pht	pht	PROPN
gsrj-12	83	8	co	co	VERB
gsrj-12	83	9	-	-	VERB
gsrj-12	83	10	administered	administer	VERB
gsrj-12	83	11	with	with	ADP
gsrj-12	83	12	tqd	tqd	PROPN
gsrj-12	83	13	showed	show	VERB
gsrj-12	83	14	reduction	reduction	NOUN
gsrj-12	83	15	in	in	ADP
gsrj-12	83	16	seizures	seizure	NOUN
gsrj-12	83	17	during	during	ADP
gsrj-12	83	18	the	the	DET
gsrj-12	83	19	first	first	ADJ
gsrj-12	83	20	3	3	NUM
gsrj-12	83	21	days	day	NOUN
gsrj-12	83	22	of	of	ADP
gsrj-12	83	23	treatment	treatment	NOUN
gsrj-12	83	24	.	.	PUNCT
gsrj-12	84	1	this	this	DET
gsrj-12	84	2	experiment	experiment	NOUN
gsrj-12	84	3	concluded	conclude	VERB
gsrj-12	84	4	that	that	SCONJ
gsrj-12	84	5	the	the	DET
gsrj-12	84	6	administration	administration	NOUN
gsrj-12	84	7	of	of	ADP
gsrj-12	84	8	tqd	tqd	PROPN
gsrj-12	84	9	allowed	allow	VERB
gsrj-12	84	10	for	for	ADP
gsrj-12	84	11	an	an	DET
gsrj-12	84	12	increased	increase	VERB
gsrj-12	84	13	uptake	uptake	NOUN
gsrj-12	84	14	of	of	ADP
gsrj-12	84	15	pht	pht	PROPN
gsrj-12	84	16	at	at	ADP
gsrj-12	84	17	the	the	DET
gsrj-12	84	18	bbb	bbb	PROPN
gsrj-12	84	19	,	,	PUNCT
gsrj-12	84	20	inhibiting	inhibit	VERB
gsrj-12	84	21	the	the	DET
gsrj-12	84	22	mechanism	mechanism	NOUN
gsrj-12	84	23	of	of	ADP
gsrj-12	84	24	p	p	NOUN
gsrj-12	84	25	-	-	PUNCT
gsrj-12	84	26	gps	gps	NOUN
gsrj-12	84	27	in	in	ADP
gsrj-12	84	28	chronic	chronic	ADJ
gsrj-12	84	29	epileptic	epileptic	ADJ
gsrj-12	84	30	rats	rat	NOUN
gsrj-12	84	31	and	and	CCONJ
gsrj-12	84	32	,	,	PUNCT
gsrj-12	84	33	thus	thus	ADV
gsrj-12	84	34	,	,	PUNCT
gsrj-12	84	35	dramatically	dramatically	ADV
gsrj-12	84	36	reducing	reduce	VERB
gsrj-12	84	37	the	the	DET
gsrj-12	84	38	frequency	frequency	NOUN
gsrj-12	84	39	of	of	ADP
gsrj-12	84	40	seizures	seizure	NOUN
gsrj-12	84	41	.	.	PUNCT
gsrj-12	85	1	this	this	DET
gsrj-12	85	2	analysis	analysis	NOUN
gsrj-12	85	3	demonstrates	demonstrate	VERB
gsrj-12	85	4	tqd	tqd	PROPN
gsrj-12	85	5	s	s	PART
gsrj-12	85	6	ability	ability	NOUN
gsrj-12	85	7	to	to	PART
gsrj-12	85	8	significantly	significantly	ADV
gsrj-12	85	9	reduce	reduce	VERB
gsrj-12	85	10	p	p	NOUN
gsrj-12	85	11	-	-	PUNCT
gsrj-12	85	12	gp	gp	NOUN
gsrj-12	85	13	activity	activity	NOUN
gsrj-12	85	14	and	and	CCONJ
gsrj-12	85	15	provides	provide	VERB
gsrj-12	85	16	a	a	DET
gsrj-12	85	17	promising	promising	ADJ
gsrj-12	85	18	approach	approach	NOUN
gsrj-12	85	19	for	for	ADP
gsrj-12	85	20	improving	improve	VERB
gsrj-12	85	21	the	the	DET
gsrj-12	85	22	standard	standard	NOUN
gsrj-12	85	23	of	of	ADP
gsrj-12	85	24	care	care	NOUN
gsrj-12	85	25	for	for	ADP
gsrj-12	85	26	refractory	refractory	NOUN
gsrj-12	85	27	epilepsy	epilepsy	NOUN
gsrj-12	85	28	.	.	PUNCT
gsrj-12	86	1	a	a	DET
gsrj-12	86	2	second	second	ADJ
gsrj-12	86	3	major	major	ADJ
gsrj-12	86	4	study	study	NOUN
gsrj-12	86	5	showed	show	VERB
gsrj-12	86	6	consistent	consistent	ADJ
gsrj-12	86	7	findings	finding	NOUN
gsrj-12	86	8	on	on	ADP
gsrj-12	86	9	the	the	DET
gsrj-12	86	10	effects	effect	NOUN
gsrj-12	86	11	of	of	ADP
gsrj-12	86	12	tqd	tqd	NOUN
gsrj-12	86	13	in	in	ADP
gsrj-12	86	14	reducing	reduce	VERB
gsrj-12	86	15	pgp	pgp	NOUN
gsrj-12	86	16	pharmacoresistance	pharmacoresistance	NOUN
gsrj-12	86	17	when	when	SCONJ
gsrj-12	86	18	co	co	VERB
gsrj-12	86	19	-	-	VERB
gsrj-12	86	20	administered	administer	VERB
gsrj-12	86	21	with	with	ADP
gsrj-12	86	22	phenobarbital	phenobarbital	ADJ
gsrj-12	86	23	(	(	PUNCT
gsrj-12	86	24	pb	pb	PROPN
gsrj-12	86	25	)	)	PUNCT
gsrj-12	86	26	,	,	PUNCT
gsrj-12	86	27	a	a	DET
gsrj-12	86	28	drug	drug	NOUN
gsrj-12	86	29	widely	widely	ADV
gsrj-12	86	30	used	use	VERB
gsrj-12	86	31	for	for	ADP
gsrj-12	86	32	its	its	PRON
gsrj-12	86	33	anti	anti	ADJ
gsrj-12	86	34	-	-	ADJ
gsrj-12	86	35	epileptic	epileptic	ADJ
gsrj-12	86	36	effect.20	effect.20	PROPN
gsrj-12	86	37	in	in	ADP
gsrj-12	86	38	this	this	DET
gsrj-12	86	39	study	study	NOUN
gsrj-12	86	40	,	,	PUNCT
gsrj-12	86	41	researchers	researcher	NOUN
gsrj-12	86	42	used	use	VERB
gsrj-12	86	43	eeg	eeg	NOUN
gsrj-12	86	44	monitoring	monitoring	NOUN
gsrj-12	86	45	and	and	CCONJ
gsrj-12	86	46	blood	blood	NOUN
gsrj-12	86	47	sampling	sample	VERB
gsrj-12	86	48	to	to	PART
gsrj-12	86	49	analyze	analyze	VERB
gsrj-12	86	50	seizure	seizure	NOUN
gsrj-12	86	51	activity	activity	NOUN
gsrj-12	86	52	and	and	CCONJ
gsrj-12	86	53	drug	drug	NOUN
gsrj-12	86	54	concentration	concentration	NOUN
gsrj-12	86	55	in	in	ADP
gsrj-12	86	56	plasma	plasma	NOUN
gsrj-12	86	57	.	.	PUNCT
gsrj-12	87	1	the	the	DET
gsrj-12	87	2	study	study	NOUN
gsrj-12	87	3	used	use	VERB
gsrj-12	87	4	a	a	DET
gsrj-12	87	5	rat	rat	NOUN
gsrj-12	87	6	model	model	NOUN
gsrj-12	87	7	of	of	ADP
gsrj-12	87	8	temporal	temporal	ADJ
gsrj-12	87	9	lobe	lobe	NOUN
gsrj-12	87	10	epilepsy	epilepsy	NOUN
gsrj-12	87	11	with	with	ADP
gsrj-12	87	12	pre	pre	ADJ
gsrj-12	87	13	-	-	ADJ
gsrj-12	87	14	established	established	ADJ
gsrj-12	87	15	drug	drug	NOUN
gsrj-12	87	16	-	-	PUNCT
gsrj-12	87	17	resistance	resistance	NOUN
gsrj-12	87	18	to	to	ADP
gsrj-12	87	19	phenobarbital	phenobarbital	ADJ
gsrj-12	87	20	.	.	PUNCT
gsrj-12	88	1	in	in	ADP
gsrj-12	88	2	one	one	NUM
gsrj-12	88	3	trial	trial	NOUN
gsrj-12	88	4	,	,	PUNCT
gsrj-12	88	5	co	co	NOUN
gsrj-12	88	6	-	-	NOUN
gsrj-12	88	7	administration	administration	NOUN
gsrj-12	88	8	of	of	ADP
gsrj-12	88	9	tqd	tqd	NOUN
gsrj-12	88	10	and	and	CCONJ
gsrj-12	88	11	pb	pb	ADP
gsrj-12	88	12	completely	completely	ADV
gsrj-12	88	13	eliminated	eliminate	VERB
gsrj-12	88	14	seizure	seizure	NOUN
gsrj-12	88	15	activity	activity	NOUN
gsrj-12	88	16	in	in	ADP
gsrj-12	88	17	four	four	NUM
gsrj-12	88	18	nonrespondent	nonrespondent	NOUN
gsrj-12	88	19	rats	rat	NOUN
gsrj-12	88	20	and	and	CCONJ
gsrj-12	88	21	reduced	reduce	VERB
gsrj-12	88	22	seizures	seizure	NOUN
gsrj-12	88	23	by	by	ADP
gsrj-12	88	24	over	over	ADP
gsrj-12	88	25	90	90	NUM
gsrj-12	88	26	%	%	NOUN
gsrj-12	88	27	in	in	ADP
gsrj-12	88	28	the	the	DET
gsrj-12	88	29	remaining	remain	VERB
gsrj-12	88	30	two	two	NUM
gsrj-12	88	31	nonrespondent	nonrespondent	NOUN
gsrj-12	88	32	rats	rat	NOUN
gsrj-12	88	33	compared	compare	VERB
gsrj-12	88	34	to	to	ADP
gsrj-12	88	35	only	only	ADV
gsrj-12	88	36	a	a	DET
gsrj-12	88	37	24	24	NUM
gsrj-12	88	38	%	%	NOUN
gsrj-12	88	39	reduction	reduction	NOUN
gsrj-12	88	40	in	in	ADP
gsrj-12	88	41	the	the	DET
gsrj-12	88	42	control	control	NOUN
gsrj-12	88	43	group	group	NOUN
gsrj-12	88	44	receiving	receive	VERB
gsrj-12	88	45	pb	pb	ADP
gsrj-12	88	46	alone	alone	ADV
gsrj-12	88	47	.	.	PUNCT
gsrj-12	89	1	in	in	ADP
gsrj-12	89	2	a	a	DET
gsrj-12	89	3	remarkable	remarkable	ADJ
gsrj-12	89	4	example	example	NOUN
gsrj-12	89	5	,	,	PUNCT
gsrj-12	89	6	one	one	NUM
gsrj-12	89	7	rat	rat	NOUN
gsrj-12	89	8	went	go	VERB
gsrj-12	89	9	from	from	ADP
gsrj-12	89	10	experiencing	experience	VERB
gsrj-12	89	11	an	an	DET
gsrj-12	89	12	extensive	extensive	ADJ
gsrj-12	89	13	number	number	NOUN
gsrj-12	89	14	of	of	ADP
gsrj-12	89	15	seizures	seizure	NOUN
gsrj-12	89	16	per	per	ADP
gsrj-12	89	17	day	day	NOUN
gsrj-12	89	18	before	before	ADP
gsrj-12	89	19	treatment	treatment	NOUN
gsrj-12	89	20	to	to	ADP
gsrj-12	89	21	becoming	become	VERB
gsrj-12	89	22	completely	completely	ADV
gsrj-12	89	23	seizure	seizure	VERB
gsrj-12	89	24	free	free	ADJ
gsrj-12	89	25	with	with	ADP
gsrj-12	89	26	the	the	DET
gsrj-12	89	27	co	co	NOUN
gsrj-12	89	28	-	-	NOUN
gsrj-12	89	29	administration	administration	NOUN
gsrj-12	89	30	of	of	ADP
gsrj-12	89	31	tqd	tqd	PROPN
gsrj-12	89	32	and	and	CCONJ
gsrj-12	89	33	pb	pb	PROPN
gsrj-12	89	34	.	.	PUNCT
gsrj-12	90	1	this	this	DET
gsrj-12	90	2	study	study	NOUN
gsrj-12	90	3	concluded	conclude	VERB
gsrj-12	90	4	that	that	SCONJ
gsrj-12	90	5	the	the	DET
gsrj-12	90	6	coadministration	coadministration	NOUN
gsrj-12	90	7	of	of	ADP
gsrj-12	90	8	tqd	tqd	NOUN
gsrj-12	90	9	with	with	ADP
gsrj-12	90	10	pb	pb	ADP
gsrj-12	90	11	completely	completely	ADV
gsrj-12	90	12	restored	restore	VERB
gsrj-12	90	13	the	the	DET
gsrj-12	90	14	anti	anti	ADJ
gsrj-12	90	15	-	-	ADJ
gsrj-12	90	16	epileptic	epileptic	ADJ
gsrj-12	90	17	effect	effect	NOUN
gsrj-12	90	18	of	of	ADP
gsrj-12	90	19	the	the	DET
gsrj-12	90	20	drug	drug	NOUN
gsrj-12	90	21	in	in	ADP
gsrj-12	90	22	pharmacoresistant	pharmacoresistant	ADJ
gsrj-12	90	23	rat	rat	NOUN
gsrj-12	90	24	models	model	NOUN
gsrj-12	90	25	of	of	ADP
gsrj-12	90	26	temporal	temporal	ADJ
gsrj-12	90	27	lobe	lobe	NOUN
gsrj-12	90	28	epilepsy.19	epilepsy.19	PRON
gsrj-12	90	29	another	another	DET
gsrj-12	90	30	comparable	comparable	ADJ
gsrj-12	90	31	study	study	NOUN
gsrj-12	90	32	conducted	conduct	VERB
gsrj-12	90	33	using	use	VERB
gsrj-12	90	34	human	human	ADJ
gsrj-12	90	35	subjects	subject	NOUN
gsrj-12	90	36	discovered	discover	VERB
gsrj-12	90	37	a	a	DET
gsrj-12	90	38	2.5	2.5	NUM
gsrj-12	90	39	fold	fold	NOUN
gsrj-12	90	40	increase	increase	NOUN
gsrj-12	90	41	in	in	ADP
gsrj-12	90	42	aed	aed	NOUN
gsrj-12	90	43	uptake	uptake	NOUN
gsrj-12	90	44	at	at	ADP
gsrj-12	90	45	the	the	DET
gsrj-12	90	46	bbb	bbb	NOUN
gsrj-12	90	47	when	when	SCONJ
gsrj-12	90	48	co	co	VERB
gsrj-12	90	49	-	-	VERB
gsrj-12	90	50	administered	administer	VERB
gsrj-12	90	51	with	with	ADP
gsrj-12	90	52	tqd.21	tqd.21	NOUN
gsrj-12	90	53	combined	combine	VERB
gsrj-12	90	54	with	with	ADP
gsrj-12	90	55	the	the	DET
gsrj-12	90	56	previous	previous	ADJ
gsrj-12	90	57	study	study	NOUN
gsrj-12	90	58	,	,	PUNCT
gsrj-12	90	59	these	these	DET
gsrj-12	90	60	results	result	NOUN
gsrj-12	90	61	provide	provide	VERB
gsrj-12	90	62	convincing	convincing	ADJ
gsrj-12	90	63	evidence	evidence	NOUN
gsrj-12	90	64	that	that	SCONJ
gsrj-12	90	65	the	the	DET
gsrj-12	90	66	p	p	NOUN
gsrj-12	90	67	-	-	PUNCT
gsrj-12	90	68	gp	gp	NOUN
gsrj-12	90	69	inhibitor	inhibitor	NOUN
gsrj-12	90	70	,	,	PUNCT
gsrj-12	90	71	tqd	tqd	NOUN
gsrj-12	90	72	,	,	PUNCT
gsrj-12	90	73	counteracts	counteract	VERB
gsrj-12	90	74	drug	drug	NOUN
gsrj-12	90	75	-	-	PUNCT
gsrj-12	90	76	resistance	resistance	NOUN
gsrj-12	90	77	in	in	ADP
gsrj-12	90	78	epileptic	epileptic	ADJ
gsrj-12	90	79	rats	rat	NOUN
gsrj-12	90	80	and	and	CCONJ
gsrj-12	90	81	could	could	AUX
gsrj-12	90	82	act	act	VERB
gsrj-12	90	83	as	as	ADP
gsrj-12	90	84	an	an	DET
gsrj-12	90	85	effective	effective	ADJ
gsrj-12	90	86	treatment	treatment	NOUN
gsrj-12	90	87	method	method	NOUN
gsrj-12	90	88	to	to	PART
gsrj-12	90	89	improve	improve	VERB
gsrj-12	90	90	the	the	DET
gsrj-12	90	91	standard	standard	NOUN
gsrj-12	90	92	of	of	ADP
gsrj-12	90	93	care	care	NOUN
gsrj-12	90	94	in	in	ADP
gsrj-12	90	95	refractory	refractory	NOUN
gsrj-12	90	96	epilepsy	epilepsy	NOUN
gsrj-12	90	97	.	.	PUNCT
gsrj-12	91	1	in	in	ADP
gsrj-12	91	2	a	a	DET
gsrj-12	91	3	single	single	ADJ
gsrj-12	91	4	case	case	NOUN
gsrj-12	91	5	study	study	NOUN
gsrj-12	91	6	,	,	PUNCT
gsrj-12	91	7	a	a	DET
gsrj-12	91	8	patient	patient	NOUN
gsrj-12	91	9	was	be	AUX
gsrj-12	91	10	administered	administer	VERB
gsrj-12	91	11	verapamil	verapamil	NOUN
gsrj-12	91	12	in	in	ADP
gsrj-12	91	13	conjunction	conjunction	NOUN
gsrj-12	91	14	with	with	ADP
gsrj-12	91	15	an	an	DET
gsrj-12	91	16	aed	aed	NOUN
gsrj-12	91	17	proven	prove	VERB
gsrj-12	91	18	to	to	PART
gsrj-12	91	19	be	be	AUX
gsrj-12	91	20	a	a	DET
gsrj-12	91	21	reliable	reliable	ADJ
gsrj-12	91	22	treatment	treatment	NOUN
gsrj-12	91	23	method.22	method.22	NOUN
gsrj-12	91	24	with	with	ADP
gsrj-12	91	25	the	the	DET
gsrj-12	91	26	combination	combination	NOUN
gsrj-12	91	27	of	of	ADP
gsrj-12	91	28	verapamil	verapamil	NOUN
gsrj-12	91	29	and	and	CCONJ
gsrj-12	91	30	the	the	DET
gsrj-12	91	31	aed	aed	NOUN
gsrj-12	91	32	,	,	PUNCT
gsrj-12	91	33	the	the	DET
gsrj-12	91	34	patient	patient	NOUN
gsrj-12	91	35	was	be	AUX
gsrj-12	91	36	able	able	ADJ
gsrj-12	91	37	to	to	PART
gsrj-12	91	38	double	double	VERB
gsrj-12	91	39	the	the	DET
gsrj-12	91	40	time	time	NOUN
gsrj-12	91	41	between	between	ADP
gsrj-12	91	42	hospitalizations	hospitalization	NOUN
gsrj-12	91	43	for	for	ADP
gsrj-12	91	44	seizures	seizure	NOUN
gsrj-12	91	45	,	,	PUNCT
gsrj-12	91	46	demonstrating	demonstrate	VERB
gsrj-12	91	47	a	a	DET
gsrj-12	91	48	significant	significant	ADJ
gsrj-12	91	49	improvement	improvement	NOUN
gsrj-12	91	50	.	.	PUNCT
gsrj-12	92	1	even	even	ADV
gsrj-12	92	2	so	so	ADV
gsrj-12	92	3	,	,	PUNCT
gsrj-12	92	4	researchers	researcher	NOUN
gsrj-12	92	5	determined	determine	VERB
gsrj-12	92	6	that	that	SCONJ
gsrj-12	92	7	it	it	PRON
gsrj-12	92	8	was	be	AUX
gsrj-12	92	9	impossible	impossible	ADJ
gsrj-12	92	10	to	to	PART
gsrj-12	92	11	isolate	isolate	VERB
gsrj-12	92	12	the	the	DET
gsrj-12	92	13	cause	cause	NOUN
gsrj-12	92	14	for	for	ADP
gsrj-12	92	15	the	the	DET
gsrj-12	92	16	improvement	improvement	NOUN
gsrj-12	92	17	,	,	PUNCT
gsrj-12	92	18	as	as	SCONJ
gsrj-12	92	19	it	it	PRON
gsrj-12	92	20	could	could	AUX
gsrj-12	92	21	have	have	AUX
gsrj-12	92	22	resulted	result	VERB
gsrj-12	92	23	from	from	ADP
gsrj-12	92	24	verapamil	verapamil	NOUN
gsrj-12	92	25	,	,	PUNCT
gsrj-12	92	26	the	the	DET
gsrj-12	92	27	viable	viable	ADJ
gsrj-12	92	28	aed	aed	NOUN
gsrj-12	92	29	,	,	PUNCT
gsrj-12	92	30	the	the	DET
gsrj-12	92	31	placebo	placebo	NOUN
gsrj-12	92	32	effect	effect	NOUN
gsrj-12	92	33	,	,	PUNCT
gsrj-12	92	34	or	or	CCONJ
gsrj-12	92	35	any	any	DET
gsrj-12	92	36	combination	combination	NOUN
gsrj-12	92	37	of	of	ADP
gsrj-12	92	38	the	the	DET
gsrj-12	92	39	three	three	NUM
gsrj-12	92	40	.	.	PUNCT
gsrj-12	93	1	only	only	ADV
gsrj-12	93	2	further	further	ADJ
gsrj-12	93	3	research	research	NOUN
gsrj-12	93	4	in	in	ADP
gsrj-12	93	5	a	a	DET
gsrj-12	93	6	controlled	control	VERB
gsrj-12	93	7	setting	setting	NOUN
gsrj-12	93	8	would	would	AUX
gsrj-12	93	9	determine	determine	VERB
gsrj-12	93	10	if	if	SCONJ
gsrj-12	93	11	verapamil	verapamil	NOUN
gsrj-12	93	12	is	be	AUX
gsrj-12	93	13	a	a	DET
gsrj-12	93	14	reliable	reliable	ADJ
gsrj-12	93	15	p	p	NOUN
gsrj-12	93	16	-	-	PUNCT
gsrj-12	93	17	gp	gp	NOUN
gsrj-12	93	18	inhibitor	inhibitor	NOUN
gsrj-12	93	19	and	and	CCONJ
gsrj-12	93	20	treatment	treatment	NOUN
gsrj-12	93	21	for	for	ADP
gsrj-12	93	22	refractory	refractory	NOUN
gsrj-12	93	23	epilepsy	epilepsy	NOUN
gsrj-12	93	24	.	.	PUNCT
gsrj-12	94	1	moreover	moreover	ADV
gsrj-12	94	2	,	,	PUNCT
gsrj-12	94	3	even	even	ADV
gsrj-12	94	4	if	if	SCONJ
gsrj-12	94	5	researchers	researcher	NOUN
gsrj-12	94	6	could	could	AUX
gsrj-12	94	7	determine	determine	VERB
gsrj-12	94	8	that	that	DET
gsrj-12	94	9	verapamil	verapamil	NOUN
gsrj-12	94	10	was	be	AUX
gsrj-12	94	11	the	the	DET
gsrj-12	94	12	cause	cause	NOUN
gsrj-12	94	13	for	for	ADP
gsrj-12	94	14	improvement	improvement	NOUN
gsrj-12	94	15	,	,	PUNCT
gsrj-12	94	16	they	they	PRON
gsrj-12	94	17	could	could	AUX
gsrj-12	94	18	not	not	PART
gsrj-12	94	19	determine	determine	VERB
gsrj-12	94	20	the	the	DET
gsrj-12	94	21	mechanism	mechanism	NOUN
gsrj-12	94	22	by	by	ADP
gsrj-12	94	23	which	which	PRON
gsrj-12	94	24	verapamil	verapamil	NOUN
gsrj-12	94	25	acted	act	VERB
gsrj-12	94	26	.	.	PUNCT
gsrj-12	95	1	with	with	ADP
gsrj-12	95	2	only	only	ADV
gsrj-12	95	3	this	this	DET
gsrj-12	95	4	one	one	NUM
gsrj-12	95	5	major	major	ADJ
gsrj-12	95	6	study	study	NOUN
gsrj-12	95	7	providing	provide	VERB
gsrj-12	95	8	inconclusive	inconclusive	ADJ
gsrj-12	95	9	evidence	evidence	NOUN
gsrj-12	95	10	,	,	PUNCT
gsrj-12	95	11	verapamil	verapamil	NOUN
gsrj-12	95	12	lacks	lack	VERB
gsrj-12	95	13	the	the	DET
gsrj-12	95	14	support	support	NOUN
gsrj-12	95	15	needed	need	VERB
gsrj-12	95	16	to	to	PART
gsrj-12	95	17	establish	establish	VERB
gsrj-12	95	18	its	its	PRON
gsrj-12	95	19	efficacy	efficacy	NOUN
gsrj-12	95	20	as	as	ADP
gsrj-12	95	21	a	a	DET
gsrj-12	95	22	p	p	NOUN
gsrj-12	95	23	-	-	PUNCT
gsrj-12	95	24	gp	gp	NOUN
gsrj-12	95	25	inhibitor	inhibitor	NOUN
gsrj-12	95	26	and	and	CCONJ
gsrj-12	95	27	positions	position	NOUN
gsrj-12	95	28	tariquidar	tariquidar	VERB
gsrj-12	95	29	as	as	ADP
gsrj-12	95	30	the	the	DET
gsrj-12	95	31	better	well	ADJ
gsrj-12	95	32	therapeutic	therapeutic	ADJ
gsrj-12	95	33	option.22	option.22	NOUN
gsrj-12	95	34	4.3	4.3	NUM
gsrj-12	95	35	limitations	limitation	NOUN
gsrj-12	95	36	of	of	ADP
gsrj-12	95	37	tqd	tqd	NOUN
gsrj-12	95	38	while	while	SCONJ
gsrj-12	95	39	many	many	ADJ
gsrj-12	95	40	developments	development	NOUN
gsrj-12	95	41	have	have	AUX
gsrj-12	95	42	been	be	AUX
gsrj-12	95	43	made	make	VERB
gsrj-12	95	44	in	in	ADP
gsrj-12	95	45	studying	study	VERB
gsrj-12	95	46	refractory	refractory	NOUN
gsrj-12	95	47	epilepsy	epilepsy	NOUN
gsrj-12	95	48	,	,	PUNCT
gsrj-12	95	49	significant	significant	ADJ
gsrj-12	95	50	uncertainty	uncertainty	NOUN
gsrj-12	95	51	must	must	AUX
gsrj-12	95	52	be	be	AUX
gsrj-12	95	53	accounted	account	VERB
gsrj-12	95	54	for	for	ADP
gsrj-12	95	55	to	to	PART
gsrj-12	95	56	better	well	ADV
gsrj-12	95	57	understand	understand	VERB
gsrj-12	95	58	treatment	treatment	NOUN
gsrj-12	95	59	options	option	NOUN
gsrj-12	95	60	,	,	PUNCT
gsrj-12	95	61	especially	especially	ADV
gsrj-12	95	62	in	in	ADP
gsrj-12	95	63	relation	relation	NOUN
gsrj-12	95	64	to	to	ADP
gsrj-12	95	65	tqd	tqd	PROPN
gsrj-12	95	66	.	.	PUNCT
gsrj-12	96	1	although	although	SCONJ
gsrj-12	96	2	tqd	tqd	PROPN
gsrj-12	96	3	shows	show	VERB
gsrj-12	96	4	the	the	DET
gsrj-12	96	5	most	most	ADV
gsrj-12	96	6	promise	promise	NOUN
gsrj-12	96	7	as	as	ADP
gsrj-12	96	8	a	a	DET
gsrj-12	96	9	treatment	treatment	NOUN
gsrj-12	96	10	for	for	ADP
gsrj-12	96	11	refractory	refractory	NOUN
gsrj-12	96	12	epilepsy	epilepsy	NOUN
gsrj-12	96	13	,	,	PUNCT
gsrj-12	96	14	there	there	PRON
gsrj-12	96	15	are	be	VERB
gsrj-12	96	16	limitations	limitation	NOUN
gsrj-12	96	17	that	that	PRON
gsrj-12	96	18	should	should	AUX
gsrj-12	96	19	be	be	AUX
gsrj-12	96	20	considered	consider	VERB
gsrj-12	96	21	.	.	PUNCT
gsrj-12	97	1	recent	recent	ADJ
gsrj-12	97	2	tqd	tqd	ADJ
gsrj-12	97	3	studies	study	NOUN
gsrj-12	97	4	have	have	AUX
gsrj-12	97	5	demonstrated	demonstrate	VERB
gsrj-12	97	6	significant	significant	ADJ
gsrj-12	97	7	adverse	adverse	ADJ
gsrj-12	97	8	events	event	NOUN
gsrj-12	97	9	.	.	PUNCT
gsrj-12	98	1	the	the	DET
gsrj-12	98	2	aforementioned	aforementioned	ADJ
gsrj-12	98	3	study	study	NOUN
gsrj-12	98	4	by	by	ADP
gsrj-12	98	5	van	van	PROPN
gsrj-12	98	6	vliet	vliet	PROPN
gsrj-12	98	7	e.	e.	PROPN
gsrj-12	98	8	a.	a.	PROPN
gsrj-12	98	9	et	et	PROPN
gsrj-12	98	10	al	al	PROPN
gsrj-12	98	11	.	.	PROPN
gsrj-12	98	12	reported	report	VERB
gsrj-12	98	13	significant	significant	ADJ
gsrj-12	98	14	abdominal	abdominal	ADJ
gsrj-12	98	15	pain	pain	NOUN
gsrj-12	98	16	in	in	ADP
gsrj-12	98	17	the	the	DET
gsrj-12	98	18	tqd	tqd	PROPN
gsrj-12	98	19	treatment	treatment	NOUN
gsrj-12	98	20	group	group	NOUN
gsrj-12	98	21	,	,	PUNCT
gsrj-12	98	22	resulting	result	VERB
gsrj-12	98	23	in	in	ADP
gsrj-12	98	24	a	a	DET
gsrj-12	98	25	dissolution	dissolution	NOUN
gsrj-12	98	26	of	of	ADP
gsrj-12	98	27	the	the	DET
gsrj-12	98	28	trial	trial	NOUN
gsrj-12	98	29	.	.	PUNCT
gsrj-12	99	1	while	while	SCONJ
gsrj-12	99	2	examining	examine	VERB
gsrj-12	99	3	the	the	DET
gsrj-12	99	4	potential	potential	ADJ
gsrj-12	99	5	application	application	NOUN
gsrj-12	99	6	of	of	ADP
gsrj-12	99	7	tqd	tqd	NOUN
gsrj-12	99	8	for	for	ADP
gsrj-12	99	9	multidrug	multidrug	NOUN
gsrj-12	99	10	resistance	resistance	NOUN
gsrj-12	99	11	in	in	ADP
gsrj-12	99	12	cancer	cancer	NOUN
gsrj-12	99	13	,	,	PUNCT
gsrj-12	99	14	research	research	NOUN
gsrj-12	99	15	 	 	SPACE
gsrj-12	99	16	was	be	AUX
gsrj-12	99	17	discontinued	discontinue	VERB
gsrj-12	99	18	after	after	SCONJ
gsrj-12	99	19	41	41	NUM
gsrj-12	99	20	%	%	NOUN
gsrj-12	99	21	of	of	ADP
gsrj-12	99	22	subjects	subject	NOUN
gsrj-12	99	23	reported	report	VERB
gsrj-12	99	24	adverse	adverse	ADJ
gsrj-12	99	25	effects	effect	NOUN
gsrj-12	99	26	to	to	ADP
gsrj-12	99	27	the	the	DET
gsrj-12	99	28	drug.23	drug.23	PROPN
gsrj-12	99	29	researchers	researcher	NOUN
gsrj-12	99	30	in	in	ADP
gsrj-12	99	31	one	one	NUM
gsrj-12	99	32	study	study	NOUN
gsrj-12	99	33	concluded	conclude	VERB
gsrj-12	99	34	that	that	SCONJ
gsrj-12	99	35	administration	administration	NOUN
gsrj-12	99	36	of	of	ADP
gsrj-12	99	37	107	107	NUM
gsrj-12	99	38	georgetown	georgetown	PROPN
gsrj-12	99	39	scientific	scientific	PROPN
gsrj-12	99	40	research	research	PROPN
gsrj-12	99	41	journal	journal	PROPN
gsrj-12	99	42	https://doi.org/10.48091/uwyg8998	https://doi.org/10.48091/uwyg8998	PROPN
gsrj-12	99	43	tqd	tqd	PROPN
gsrj-12	99	44	was	be	AUX
gsrj-12	99	45	not	not	PART
gsrj-12	99	46	associated	associate	VERB
gsrj-12	99	47	with	with	ADP
gsrj-12	99	48	enhanced	enhanced	ADJ
gsrj-12	99	49	toxicity	toxicity	NOUN
gsrj-12	99	50	or	or	CCONJ
gsrj-12	99	51	altered	alter	VERB
gsrj-12	99	52	blood	blood	NOUN
gsrj-12	99	53	plasma	plasma	NOUN
gsrj-12	99	54	pharmacokinetics	pharmacokinetic	NOUN
gsrj-12	99	55	as	as	ADP
gsrj-12	99	56	in	in	ADP
gsrj-12	99	57	the	the	DET
gsrj-12	99	58	case	case	NOUN
gsrj-12	99	59	of	of	ADP
gsrj-12	99	60	several	several	ADJ
gsrj-12	99	61	other	other	ADJ
gsrj-12	99	62	p	p	NOUN
gsrj-12	99	63	-	-	PUNCT
gsrj-12	99	64	gp	gp	NOUN
gsrj-12	99	65	inhibitors	inhibitor	NOUN
gsrj-12	99	66	,	,	PUNCT
gsrj-12	99	67	yet	yet	CCONJ
gsrj-12	99	68	these	these	DET
gsrj-12	99	69	results	result	NOUN
gsrj-12	99	70	have	have	AUX
gsrj-12	99	71	not	not	PART
gsrj-12	99	72	been	be	AUX
gsrj-12	99	73	replicated	replicate	VERB
gsrj-12	99	74	in	in	ADP
gsrj-12	99	75	similar	similar	ADJ
gsrj-12	99	76	studies	study	NOUN
gsrj-12	99	77	nor	nor	CCONJ
gsrj-12	99	78	demonstrate	demonstrate	VERB
gsrj-12	99	79	consistency	consistency	NOUN
gsrj-12	99	80	with	with	ADP
gsrj-12	99	81	other	other	ADJ
gsrj-12	99	82	findings	finding	NOUN
gsrj-12	99	83	.	.	PUNCT
gsrj-12	100	1	20	20	NUM
gsrj-12	100	2	two	two	NUM
gsrj-12	100	3	studies	study	NOUN
gsrj-12	100	4	revealed	reveal	VERB
gsrj-12	100	5	that	that	SCONJ
gsrj-12	100	6	,	,	PUNCT
gsrj-12	100	7	despite	despite	SCONJ
gsrj-12	100	8	the	the	DET
gsrj-12	100	9	significant	significant	ADJ
gsrj-12	100	10	improvement	improvement	NOUN
gsrj-12	100	11	in	in	ADP
gsrj-12	100	12	seizure	seizure	NOUN
gsrj-12	100	13	activity	activity	NOUN
gsrj-12	100	14	during	during	ADP
gsrj-12	100	15	the	the	DET
gsrj-12	100	16	first	first	ADJ
gsrj-12	100	17	few	few	ADJ
gsrj-12	100	18	days	day	NOUN
gsrj-12	100	19	of	of	ADP
gsrj-12	100	20	tqd	tqd	NOUN
gsrj-12	100	21	and	and	CCONJ
gsrj-12	100	22	aed	aed	NOUN
gsrj-12	100	23	coadministration	coadministration	NOUN
gsrj-12	100	24	,	,	PUNCT
gsrj-12	100	25	tqd	tqd	ADJ
gsrj-12	100	26	tolerance	tolerance	NOUN
gsrj-12	100	27	eventually	eventually	ADV
gsrj-12	100	28	developed	develop	VERB
gsrj-12	100	29	through	through	ADP
gsrj-12	100	30	unknown	unknown	ADJ
gsrj-12	100	31	mechanisms.19	mechanisms.19	NOUN
gsrj-12	100	32	,	,	PUNCT
gsrj-12	100	33	21	21	NUM
gsrj-12	100	34	these	these	DET
gsrj-12	100	35	results	result	NOUN
gsrj-12	100	36	implicate	implicate	VERB
gsrj-12	100	37	the	the	DET
gsrj-12	100	38	need	need	NOUN
gsrj-12	100	39	for	for	ADP
gsrj-12	100	40	further	further	ADJ
gsrj-12	100	41	exploration	exploration	NOUN
gsrj-12	100	42	of	of	ADP
gsrj-12	100	43	the	the	DET
gsrj-12	100	44	pharmacology	pharmacology	NOUN
gsrj-12	100	45	of	of	ADP
gsrj-12	100	46	tqd	tqd	NOUN
gsrj-12	100	47	in	in	ADP
gsrj-12	100	48	order	order	NOUN
gsrj-12	100	49	to	to	PART
gsrj-12	100	50	reduce	reduce	VERB
gsrj-12	100	51	tolerance	tolerance	NOUN
gsrj-12	100	52	to	to	ADP
gsrj-12	100	53	the	the	DET
gsrj-12	100	54	drug	drug	NOUN
gsrj-12	100	55	.	.	PUNCT
gsrj-12	101	1	tqd	tqd	PROPN
gsrj-12	101	2	could	could	AUX
gsrj-12	101	3	potentially	potentially	ADV
gsrj-12	101	4	lead	lead	VERB
gsrj-12	101	5	to	to	ADP
gsrj-12	101	6	toxicity	toxicity	NOUN
gsrj-12	101	7	in	in	ADP
gsrj-12	101	8	organs	organ	NOUN
gsrj-12	101	9	other	other	ADJ
gsrj-12	101	10	than	than	ADP
gsrj-12	101	11	the	the	DET
gsrj-12	101	12	brain	brain	NOUN
gsrj-12	101	13	,	,	PUNCT
gsrj-12	101	14	such	such	ADJ
gsrj-12	101	15	as	as	ADP
gsrj-12	101	16	the	the	DET
gsrj-12	101	17	intestines	intestine	NOUN
gsrj-12	101	18	,	,	PUNCT
gsrj-12	101	19	liver	liver	NOUN
gsrj-12	101	20	,	,	PUNCT
gsrj-12	101	21	and	and	CCONJ
gsrj-12	101	22	kidneys	kidney	NOUN
gsrj-12	101	23	by	by	ADP
gsrj-12	101	24	inhibiting	inhibit	VERB
gsrj-12	101	25	the	the	DET
gsrj-12	101	26	efflux	efflux	ADJ
gsrj-12	101	27	effect	effect	NOUN
gsrj-12	101	28	of	of	ADP
gsrj-12	101	29	p	p	NOUN
gsrj-12	101	30	-	-	PUNCT
gsrj-12	101	31	gps	gps	PROPN
gsrj-12	101	32	expressed	express	VERB
gsrj-12	101	33	in	in	ADP
gsrj-12	101	34	those	those	DET
gsrj-12	101	35	organs	organ	NOUN
gsrj-12	101	36	as	as	SCONJ
gsrj-12	101	37	well.17	well.17	PROPN
gsrj-12	101	38	more	more	ADJ
gsrj-12	101	39	knowledge	knowledge	NOUN
gsrj-12	101	40	on	on	ADP
gsrj-12	101	41	the	the	DET
gsrj-12	101	42	adverse	adverse	ADJ
gsrj-12	101	43	events	event	NOUN
gsrj-12	101	44	of	of	ADP
gsrj-12	101	45	tqd	tqd	NOUN
gsrj-12	101	46	is	be	AUX
gsrj-12	101	47	necessary	necessary	ADJ
gsrj-12	101	48	to	to	PART
gsrj-12	101	49	ensure	ensure	VERB
gsrj-12	101	50	its	its	PRON
gsrj-12	101	51	safety	safety	NOUN
gsrj-12	101	52	in	in	ADP
gsrj-12	101	53	the	the	DET
gsrj-12	101	54	clinical	clinical	ADJ
gsrj-12	101	55	setting	setting	NOUN
gsrj-12	101	56	.	.	PUNCT
gsrj-12	102	1	additionally	additionally	ADV
gsrj-12	102	2	,	,	PUNCT
gsrj-12	102	3	since	since	SCONJ
gsrj-12	102	4	current	current	ADJ
gsrj-12	102	5	research	research	NOUN
gsrj-12	102	6	predominantly	predominantly	ADV
gsrj-12	102	7	considers	consider	VERB
gsrj-12	102	8	the	the	DET
gsrj-12	102	9	effects	effect	NOUN
gsrj-12	102	10	of	of	ADP
gsrj-12	102	11	tqd	tqd	NOUN
gsrj-12	102	12	for	for	ADP
gsrj-12	102	13	two	two	NUM
gsrj-12	102	14	types	type	NOUN
gsrj-12	102	15	of	of	ADP
gsrj-12	102	16	aeds	aed	NOUN
gsrj-12	102	17	(	(	PUNCT
gsrj-12	102	18	phenobarbital	phenobarbital	ADJ
gsrj-12	102	19	and	and	CCONJ
gsrj-12	102	20	phenytoin	phenytoin	NOUN
gsrj-12	102	21	)	)	PUNCT
gsrj-12	102	22	,	,	PUNCT
gsrj-12	102	23	further	further	ADJ
gsrj-12	102	24	investigation	investigation	NOUN
gsrj-12	102	25	on	on	ADP
gsrj-12	102	26	whether	whether	SCONJ
gsrj-12	102	27	these	these	DET
gsrj-12	102	28	effects	effect	NOUN
gsrj-12	102	29	can	can	AUX
gsrj-12	102	30	be	be	AUX
gsrj-12	102	31	extrapolated	extrapolate	VERB
gsrj-12	102	32	to	to	ADP
gsrj-12	102	33	a	a	DET
gsrj-12	102	34	broader	broad	ADJ
gsrj-12	102	35	range	range	NOUN
gsrj-12	102	36	of	of	ADP
gsrj-12	102	37	aeds	aed	NOUN
gsrj-12	102	38	would	would	AUX
gsrj-12	102	39	provide	provide	VERB
gsrj-12	102	40	a	a	DET
gsrj-12	102	41	more	more	ADV
gsrj-12	102	42	comprehensive	comprehensive	ADJ
gsrj-12	102	43	treatment	treatment	NOUN
gsrj-12	102	44	method	method	NOUN
gsrj-12	102	45	for	for	ADP
gsrj-12	102	46	refractory	refractory	NOUN
gsrj-12	102	47	epilepsy	epilepsy	NOUN
gsrj-12	102	48	.	.	PUNCT
gsrj-12	103	1	conclusion	conclusion	NOUN
gsrj-12	103	2	refractory	refractory	NOUN
gsrj-12	103	3	epilepsy	epilepsy	NOUN
gsrj-12	103	4	is	be	AUX
gsrj-12	103	5	a	a	DET
gsrj-12	103	6	complex	complex	ADJ
gsrj-12	103	7	,	,	PUNCT
gsrj-12	103	8	multifaceted	multifaceted	ADJ
gsrj-12	103	9	disease	disease	NOUN
gsrj-12	103	10	that	that	PRON
gsrj-12	103	11	impacts	impact	VERB
gsrj-12	103	12	millions	million	NOUN
gsrj-12	103	13	of	of	ADP
gsrj-12	103	14	people	people	NOUN
gsrj-12	103	15	worldwide	worldwide	ADV
gsrj-12	103	16	.	.	PUNCT
gsrj-12	104	1	the	the	DET
gsrj-12	104	2	drug	drug	NOUN
gsrj-12	104	3	-	-	PUNCT
gsrj-12	104	4	resistant	resistant	ADJ
gsrj-12	104	5	nature	nature	NOUN
gsrj-12	104	6	of	of	ADP
gsrj-12	104	7	this	this	DET
gsrj-12	104	8	condition	condition	NOUN
gsrj-12	104	9	poses	pose	VERB
gsrj-12	104	10	unique	unique	ADJ
gsrj-12	104	11	challenges	challenge	NOUN
gsrj-12	104	12	for	for	ADP
gsrj-12	104	13	physicians	physician	NOUN
gsrj-12	104	14	attempting	attempt	VERB
gsrj-12	104	15	to	to	PART
gsrj-12	104	16	provide	provide	VERB
gsrj-12	104	17	therapeutic	therapeutic	ADJ
gsrj-12	104	18	care	care	NOUN
gsrj-12	104	19	to	to	ADP
gsrj-12	104	20	patients	patient	NOUN
gsrj-12	104	21	and	and	CCONJ
gsrj-12	104	22	establishes	establish	VERB
gsrj-12	104	23	an	an	DET
gsrj-12	104	24	urgency	urgency	NOUN
gsrj-12	104	25	for	for	SCONJ
gsrj-12	104	26	researchers	researcher	NOUN
gsrj-12	104	27	to	to	PART
gsrj-12	104	28	determine	determine	VERB
gsrj-12	104	29	its	its	PRON
gsrj-12	104	30	mechanisms	mechanism	NOUN
gsrj-12	104	31	.	.	PUNCT
gsrj-12	105	1	while	while	SCONJ
gsrj-12	105	2	many	many	ADJ
gsrj-12	105	3	hypotheses	hypothesis	NOUN
gsrj-12	105	4	attempt	attempt	VERB
gsrj-12	105	5	to	to	PART
gsrj-12	105	6	explain	explain	VERB
gsrj-12	105	7	the	the	DET
gsrj-12	105	8	mechanisms	mechanism	NOUN
gsrj-12	105	9	of	of	ADP
gsrj-12	105	10	refractory	refractory	NOUN
gsrj-12	105	11	epilepsy	epilepsy	NOUN
gsrj-12	105	12	,	,	PUNCT
gsrj-12	105	13	the	the	DET
gsrj-12	105	14	overexpression	overexpression	NOUN
gsrj-12	105	15	of	of	ADP
gsrj-12	105	16	p	p	NOUN
gsrj-12	105	17	-	-	PUNCT
gsrj-12	105	18	glycoprotein	glycoprotein	NOUN
gsrj-12	105	19	(	(	PUNCT
gsrj-12	105	20	p	p	NOUN
gsrj-12	105	21	-	-	PUNCT
gsrj-12	105	22	gps	gps	NOUN
gsrj-12	105	23	)	)	PUNCT
gsrj-12	105	24	transporters	transporter	NOUN
gsrj-12	105	25	in	in	ADP
gsrj-12	105	26	endothelial	endothelial	ADJ
gsrj-12	105	27	cells	cell	NOUN
gsrj-12	105	28	at	at	ADP
gsrj-12	105	29	the	the	DET
gsrj-12	105	30	blood	blood	NOUN
gsrj-12	105	31	brain	brain	NOUN
gsrj-12	105	32	barrier	barrier	NOUN
gsrj-12	105	33	best	good	ADJ
gsrj-12	105	34	accounts	account	VERB
gsrj-12	105	35	for	for	ADP
gsrj-12	105	36	pharmacoresistance	pharmacoresistance	NOUN
gsrj-12	105	37	.	.	PUNCT
gsrj-12	106	1	across	across	ADP
gsrj-12	106	2	the	the	DET
gsrj-12	106	3	numerous	numerous	ADJ
gsrj-12	106	4	studies	study	NOUN
gsrj-12	106	5	examined	examine	VERB
gsrj-12	106	6	within	within	ADP
gsrj-12	106	7	this	this	DET
gsrj-12	106	8	review	review	NOUN
gsrj-12	106	9	,	,	PUNCT
gsrj-12	106	10	a	a	DET
gsrj-12	106	11	clear	clear	ADJ
gsrj-12	106	12	relationship	relationship	NOUN
gsrj-12	106	13	was	be	AUX
gsrj-12	106	14	identified	identify	VERB
gsrj-12	106	15	between	between	ADP
gsrj-12	106	16	the	the	DET
gsrj-12	106	17	overexpression	overexpression	NOUN
gsrj-12	106	18	of	of	ADP
gsrj-12	106	19	p	p	NOUN
gsrj-12	106	20	-	-	PUNCT
gsrj-12	106	21	glycoproteins	glycoprotein	NOUN
gsrj-12	106	22	in	in	ADP
gsrj-12	106	23	epileptic	epileptic	ADJ
gsrj-12	106	24	brain	brain	NOUN
gsrj-12	106	25	tissue	tissue	NOUN
gsrj-12	106	26	and	and	CCONJ
gsrj-12	106	27	reduced	reduce	VERB
gsrj-12	106	28	uptake	uptake	NOUN
gsrj-12	106	29	of	of	ADP
gsrj-12	106	30	antiepileptic	antiepileptic	ADJ
gsrj-12	106	31	drugs	drug	NOUN
gsrj-12	106	32	(	(	PUNCT
gsrj-12	106	33	aeds	aed	NOUN
gsrj-12	106	34	)	)	PUNCT
gsrj-12	106	35	at	at	ADP
gsrj-12	106	36	the	the	DET
gsrj-12	106	37	blood	blood	NOUN
gsrj-12	106	38	brain	brain	NOUN
gsrj-12	106	39	barrier	barrier	NOUN
gsrj-12	106	40	.	.	PUNCT
gsrj-12	107	1	the	the	DET
gsrj-12	107	2	consistent	consistent	ADJ
gsrj-12	107	3	and	and	CCONJ
gsrj-12	107	4	replicated	replicated	ADJ
gsrj-12	107	5	association	association	NOUN
gsrj-12	107	6	between	between	ADP
gsrj-12	107	7	pgp	pgp	NOUN
gsrj-12	107	8	overexpression	overexpression	NOUN
gsrj-12	107	9	and	and	CCONJ
gsrj-12	107	10	reduced	reduce	VERB
gsrj-12	107	11	aed	aed	NOUN
gsrj-12	107	12	concentration	concentration	NOUN
gsrj-12	107	13	demonstrates	demonstrate	VERB
gsrj-12	107	14	that	that	SCONJ
gsrj-12	107	15	,	,	PUNCT
gsrj-12	107	16	as	as	ADP
gsrj-12	107	17	a	a	DET
gsrj-12	107	18	result	result	NOUN
gsrj-12	107	19	of	of	ADP
gsrj-12	107	20	the	the	DET
gsrj-12	107	21	drug	drug	NOUN
gsrj-12	107	22	efflux	efflux	NOUN
gsrj-12	107	23	process	process	NOUN
gsrj-12	107	24	,	,	PUNCT
gsrj-12	107	25	p	p	NOUN
gsrj-12	107	26	-	-	PUNCT
gsrj-12	107	27	gp	gp	NOUN
gsrj-12	107	28	overexpression	overexpression	NOUN
gsrj-12	107	29	is	be	AUX
gsrj-12	107	30	the	the	DET
gsrj-12	107	31	primary	primary	ADJ
gsrj-12	107	32	mechanism	mechanism	NOUN
gsrj-12	107	33	of	of	ADP
gsrj-12	107	34	decreased	decrease	VERB
gsrj-12	107	35	drug	drug	NOUN
gsrj-12	107	36	efficacy	efficacy	NOUN
gsrj-12	107	37	in	in	ADP
gsrj-12	107	38	refractory	refractory	NOUN
gsrj-12	107	39	epilepsy	epilepsy	NOUN
gsrj-12	107	40	patients	patient	NOUN
gsrj-12	107	41	.	.	PUNCT
gsrj-12	108	1	with	with	ADP
gsrj-12	108	2	p	p	NOUN
gsrj-12	108	3	-	-	PUNCT
gsrj-12	108	4	gp	gp	NOUN
gsrj-12	108	5	overexpression	overexpression	NOUN
gsrj-12	108	6	identified	identify	VERB
gsrj-12	108	7	as	as	ADP
gsrj-12	108	8	the	the	DET
gsrj-12	108	9	lead	lead	NOUN
gsrj-12	108	10	cause	cause	NOUN
gsrj-12	108	11	of	of	ADP
gsrj-12	108	12	refractory	refractory	NOUN
gsrj-12	108	13	epilepsy	epilepsy	NOUN
gsrj-12	108	14	,	,	PUNCT
gsrj-12	108	15	the	the	DET
gsrj-12	108	16	focus	focus	NOUN
gsrj-12	108	17	shifts	shift	NOUN
gsrj-12	108	18	towards	towards	ADP
gsrj-12	108	19	improving	improve	VERB
gsrj-12	108	20	the	the	DET
gsrj-12	108	21	standard	standard	NOUN
gsrj-12	108	22	of	of	ADP
gsrj-12	108	23	care	care	NOUN
gsrj-12	108	24	for	for	ADP
gsrj-12	108	25	refractory	refractory	NOUN
gsrj-12	108	26	epilepsy	epilepsy	NOUN
gsrj-12	108	27	patients	patient	NOUN
gsrj-12	108	28	through	through	ADP
gsrj-12	108	29	the	the	DET
gsrj-12	108	30	proposed	propose	VERB
gsrj-12	108	31	treatment	treatment	NOUN
gsrj-12	108	32	method	method	NOUN
gsrj-12	108	33	of	of	ADP
gsrj-12	108	34	p	p	NOUN
gsrj-12	108	35	-	-	PUNCT
gsrj-12	108	36	gp	gp	NOUN
gsrj-12	108	37	inhibition	inhibition	NOUN
gsrj-12	108	38	.	.	PUNCT
gsrj-12	109	1	this	this	DET
gsrj-12	109	2	treatment	treatment	NOUN
gsrj-12	109	3	method	method	NOUN
gsrj-12	109	4	suggests	suggest	VERB
gsrj-12	109	5	that	that	SCONJ
gsrj-12	109	6	the	the	DET
gsrj-12	109	7	coadministration	coadministration	NOUN
gsrj-12	109	8	of	of	ADP
gsrj-12	109	9	an	an	DET
gsrj-12	109	10	aed	aed	NOUN
gsrj-12	109	11	and	and	CCONJ
gsrj-12	109	12	p	p	NOUN
gsrj-12	109	13	-	-	PUNCT
gsrj-12	109	14	gp	gp	NOUN
gsrj-12	109	15	inhibitor	inhibitor	NOUN
gsrj-12	109	16	reduces	reduce	VERB
gsrj-12	109	17	the	the	DET
gsrj-12	109	18	efflux	efflux	NOUN
gsrj-12	109	19	effects	effect	NOUN
gsrj-12	109	20	of	of	ADP
gsrj-12	109	21	p	p	NOUN
gsrj-12	109	22	-	-	PUNCT
gsrj-12	109	23	gp	gp	NOUN
gsrj-12	109	24	and	and	CCONJ
gsrj-12	109	25	allows	allow	VERB
gsrj-12	109	26	for	for	ADP
gsrj-12	109	27	increased	increase	VERB
gsrj-12	109	28	aed	aed	NOUN
gsrj-12	109	29	uptake	uptake	NOUN
gsrj-12	109	30	at	at	ADP
gsrj-12	109	31	the	the	DET
gsrj-12	109	32	blood	blood	NOUN
gsrj-12	109	33	brain	brain	NOUN
gsrj-12	109	34	barrier	barrier	NOUN
gsrj-12	109	35	,	,	PUNCT
gsrj-12	109	36	thereby	thereby	ADV
gsrj-12	109	37	increasing	increase	VERB
gsrj-12	109	38	the	the	DET
gsrj-12	109	39	therapeutic	therapeutic	ADJ
gsrj-12	109	40	effect	effect	NOUN
gsrj-12	109	41	of	of	ADP
gsrj-12	109	42	the	the	DET
gsrj-12	109	43	drug	drug	NOUN
gsrj-12	109	44	.	.	PUNCT
gsrj-12	110	1	two	two	NUM
gsrj-12	110	2	p	p	ADJ
gsrj-12	110	3	-	-	PUNCT
gsrj-12	110	4	gp	gp	NOUN
gsrj-12	110	5	inhibitors	inhibitor	NOUN
gsrj-12	110	6	,	,	PUNCT
gsrj-12	110	7	tariquidar	tariquidar	PRON
gsrj-12	110	8	(	(	PUNCT
gsrj-12	110	9	tqd	tqd	NOUN
gsrj-12	110	10	)	)	PUNCT
gsrj-12	110	11	and	and	CCONJ
gsrj-12	110	12	verapamil	verapamil	NOUN
gsrj-12	110	13	,	,	PUNCT
gsrj-12	110	14	have	have	AUX
gsrj-12	110	15	been	be	AUX
gsrj-12	110	16	identified	identify	VERB
gsrj-12	110	17	as	as	ADP
gsrj-12	110	18	potential	potential	ADJ
gsrj-12	110	19	treatment	treatment	NOUN
gsrj-12	110	20	options	option	NOUN
gsrj-12	110	21	.	.	PUNCT
gsrj-12	111	1	however	however	ADV
gsrj-12	111	2	,	,	PUNCT
gsrj-12	111	3	due	due	ADP
gsrj-12	111	4	to	to	ADP
gsrj-12	111	5	the	the	DET
gsrj-12	111	6	lack	lack	NOUN
gsrj-12	111	7	of	of	ADP
gsrj-12	111	8	evidence	evidence	NOUN
gsrj-12	111	9	supporting	support	VERB
gsrj-12	111	10	verapamil	verapamil	NOUN
gsrj-12	111	11	s	s	PART
gsrj-12	111	12	efficacy	efficacy	NOUN
gsrj-12	111	13	,	,	PUNCT
gsrj-12	111	14	it	it	PRON
gsrj-12	111	15	has	have	AUX
gsrj-12	111	16	�	�	PROPN
gsrj-12	111	17	been	be	AUX
gsrj-12	111	18	determined	determine	VERB
gsrj-12	111	19	that	that	SCONJ
gsrj-12	111	20	tqd	tqd	PROPN
gsrj-12	111	21	poses	pose	VERB
gsrj-12	111	22	the	the	DET
gsrj-12	111	23	most	most	ADV
gsrj-12	111	24	promise	promise	NOUN
gsrj-12	111	25	as	as	ADP
gsrj-12	111	26	an	an	DET
gsrj-12	111	27	effective	effective	ADJ
gsrj-12	111	28	treatment	treatment	NOUN
gsrj-12	111	29	option	option	NOUN
gsrj-12	111	30	for	for	ADP
gsrj-12	111	31	refractory	refractory	NOUN
gsrj-12	111	32	epilepsy	epilepsy	NOUN
gsrj-12	111	33	.	.	PUNCT
gsrj-12	112	1	many	many	ADJ
gsrj-12	112	2	studies	study	NOUN
gsrj-12	112	3	examined	examine	VERB
gsrj-12	112	4	within	within	ADP
gsrj-12	112	5	this	this	DET
gsrj-12	112	6	review	review	NOUN
gsrj-12	112	7	showed	show	VERB
gsrj-12	112	8	that	that	SCONJ
gsrj-12	112	9	when	when	SCONJ
gsrj-12	112	10	co	co	VERB
gsrj-12	112	11	-	-	VERB
gsrj-12	112	12	administered	administer	VERB
gsrj-12	112	13	with	with	ADP
gsrj-12	112	14	an	an	DET
gsrj-12	112	15	established	establish	VERB
gsrj-12	112	16	aed	aed	NOUN
gsrj-12	112	17	,	,	PUNCT
gsrj-12	112	18	tqd	tqd	PROPN
gsrj-12	112	19	led	lead	VERB
gsrj-12	112	20	to	to	ADP
gsrj-12	112	21	increased	increase	VERB
gsrj-12	112	22	aed	aed	NOUN
gsrj-12	112	23	concentration	concentration	NOUN
gsrj-12	112	24	in	in	ADP
gsrj-12	112	25	brain	brain	NOUN
gsrj-12	112	26	tissue	tissue	NOUN
gsrj-12	112	27	and	and	CCONJ
gsrj-12	112	28	,	,	PUNCT
gsrj-12	112	29	thus	thus	ADV
gsrj-12	112	30	,	,	PUNCT
gsrj-12	112	31	greater	great	ADJ
gsrj-12	112	32	drug	drug	NOUN
gsrj-12	112	33	efficacy	efficacy	NOUN
gsrj-12	112	34	.	.	PUNCT
gsrj-12	113	1	despite	despite	SCONJ
gsrj-12	113	2	these	these	DET
gsrj-12	113	3	promising	promising	ADJ
gsrj-12	113	4	findings	finding	NOUN
gsrj-12	113	5	,	,	PUNCT
gsrj-12	113	6	tariquidar	tariquidar	PRON
gsrj-12	113	7	still	still	ADV
gsrj-12	113	8	poses	pose	VERB
gsrj-12	113	9	limitations	limitation	NOUN
gsrj-12	113	10	that	that	PRON
gsrj-12	113	11	warrant	warrant	VERB
gsrj-12	113	12	further	further	ADJ
gsrj-12	113	13	investigation	investigation	NOUN
gsrj-12	113	14	.	.	PUNCT
gsrj-12	114	1	many	many	ADJ
gsrj-12	114	2	studies	study	NOUN
gsrj-12	114	3	have	have	AUX
gsrj-12	114	4	shown	show	VERB
gsrj-12	114	5	that	that	SCONJ
gsrj-12	114	6	tqd	tqd	PROPN
gsrj-12	114	7	may	may	AUX
gsrj-12	114	8	cause	cause	VERB
gsrj-12	114	9	adverse	adverse	ADJ
gsrj-12	114	10	events	event	NOUN
gsrj-12	114	11	such	such	ADJ
gsrj-12	114	12	as	as	ADP
gsrj-12	114	13	tolerance	tolerance	NOUN
gsrj-12	114	14	and	and	CCONJ
gsrj-12	114	15	toxicity	toxicity	NOUN
gsrj-12	114	16	.	.	PUNCT
gsrj-12	115	1	additionally	additionally	ADV
gsrj-12	115	2	,	,	PUNCT
gsrj-12	115	3	very	very	ADV
gsrj-12	115	4	few	few	ADJ
gsrj-12	115	5	studies	study	NOUN
gsrj-12	115	6	using	use	VERB
gsrj-12	115	7	human	human	ADJ
gsrj-12	115	8	subjects	subject	NOUN
gsrj-12	115	9	have	have	AUX
gsrj-12	115	10	been	be	AUX
gsrj-12	115	11	conducted	conduct	VERB
gsrj-12	115	12	on	on	ADP
gsrj-12	115	13	tqd	tqd	ADJ
gsrj-12	115	14	inhibitors	inhibitor	NOUN
gsrj-12	115	15	and	and	CCONJ
gsrj-12	115	16	their	their	PRON
gsrj-12	115	17	effect	effect	NOUN
gsrj-12	115	18	with	with	ADP
gsrj-12	115	19	various	various	ADJ
gsrj-12	115	20	aeds	aed	NOUN
gsrj-12	115	21	.	.	PUNCT
gsrj-12	116	1	with	with	ADP
gsrj-12	116	2	these	these	DET
gsrj-12	116	3	limitations	limitation	NOUN
gsrj-12	116	4	and	and	CCONJ
gsrj-12	116	5	gaps	gap	NOUN
gsrj-12	116	6	in	in	ADP
gsrj-12	116	7	knowledge	knowledge	NOUN
gsrj-12	116	8	,	,	PUNCT
gsrj-12	116	9	the	the	DET
gsrj-12	116	10	need	need	NOUN
gsrj-12	116	11	for	for	ADP
gsrj-12	116	12	more	more	ADV
gsrj-12	116	13	clinical	clinical	ADJ
gsrj-12	116	14	trials	trial	NOUN
gsrj-12	116	15	specifically	specifically	ADV
gsrj-12	116	16	investigating	investigate	VERB
gsrj-12	116	17	the	the	DET
gsrj-12	116	18	effects	effect	NOUN
gsrj-12	116	19	of	of	ADP
gsrj-12	116	20	tqd	tqd	NOUN
gsrj-12	116	21	and	and	CCONJ
gsrj-12	116	22	other	other	ADJ
gsrj-12	116	23	p	p	NOUN
gsrj-12	116	24	-	-	PUNCT
gsrj-12	116	25	gp	gp	NOUN
gsrj-12	116	26	inhibitors	inhibitor	NOUN
gsrj-12	116	27	such	such	ADJ
gsrj-12	116	28	as	as	ADP
gsrj-12	116	29	verapamil	verapamil	NOUN
gsrj-12	116	30	is	be	AUX
gsrj-12	116	31	clear	clear	ADJ
gsrj-12	116	32	.	.	PUNCT
gsrj-12	117	1	in	in	ADP
gsrj-12	117	2	addition	addition	NOUN
gsrj-12	117	3	,	,	PUNCT
gsrj-12	117	4	future	future	ADJ
gsrj-12	117	5	studies	study	NOUN
gsrj-12	117	6	should	should	AUX
gsrj-12	117	7	be	be	AUX
gsrj-12	117	8	conducted	conduct	VERB
gsrj-12	117	9	to	to	PART
gsrj-12	117	10	determine	determine	VERB
gsrj-12	117	11	the	the	DET
gsrj-12	117	12	mechanisms	mechanism	NOUN
gsrj-12	117	13	of	of	ADP
gsrj-12	117	14	tqd	tqd	ADJ
gsrj-12	117	15	tolerance	tolerance	NOUN
gsrj-12	117	16	and	and	CCONJ
gsrj-12	117	17	toxicity	toxicity	NOUN
gsrj-12	117	18	in	in	ADP
gsrj-12	117	19	order	order	NOUN
gsrj-12	117	20	to	to	PART
gsrj-12	117	21	improve	improve	VERB
gsrj-12	117	22	the	the	DET
gsrj-12	117	23	safety	safety	NOUN
gsrj-12	117	24	and	and	CCONJ
gsrj-12	117	25	efficacy	efficacy	NOUN
gsrj-12	117	26	of	of	ADP
gsrj-12	117	27	tqd	tqd	PROPN
gsrj-12	117	28	.	.	PUNCT
gsrj-12	118	1	such	such	ADJ
gsrj-12	118	2	findings	finding	NOUN
gsrj-12	118	3	may	may	AUX
gsrj-12	118	4	affirm	affirm	VERB
gsrj-12	118	5	the	the	DET
gsrj-12	118	6	ability	ability	NOUN
gsrj-12	118	7	of	of	ADP
gsrj-12	118	8	1	1	NUM
gsrj-12	118	9	�	�	PROPN
gsrj-12	118	10	hq	hq	NOUN
gsrj-12	118	11	�	�	PROPN
gsrj-12	118	12	joijcjupsup	joijcjupsup	PROPN
gsrj-12	118	13	�	�	PROPN
gsrj-12	118	14	pwfsdpnf	pwfsdpnf	PROPN
gsrj-12	118	15	�	�	PROPN
gsrj-12	118	16	qibsnbdpsftjtubodf	qibsnbdpsftjtubodf	PROPN
gsrj-12	118	17	�	�	PROPN
gsrj-12	118	18	boe	boe	PROPN
gsrj-12	118	19	�	�	PROPN
gsrj-12	118	20	gjobmmz	gjobmmz	PROPN
gsrj-12	118	21	�	�	PROPN
gsrj-12	118	22	qspwjefbo	qspwjefbo	PROPN
gsrj-12	118	23	�	�	PROPN
gsrj-12	118	24	fggfdujwf	fggfdujwf	VERB
gsrj-12	118	25	�	�	PROPN
gsrj-12	118	26	uifsbqfvujd	uifsbqfvujd	NOUN
gsrj-12	118	27	�	�	PROPN
gsrj-12	118	28	tusbufhz	tusbufhz	ADJ
gsrj-12	118	29	�	�	PROPN
gsrj-12	118	30	gps	gps	PROPN
gsrj-12	118	31	�	�	PROPN
gsrj-12	118	32	sfgsbdupsz	sfgsbdupsz	NOUN
gsrj-12	118	33	�	�	PROPN
gsrj-12	118	34	fqjmfqtz	fqjmfqtz	NOUN
gsrj-12	118	35	�	�	PROPN
gsrj-12	118	36	�	�	PROPN
gsrj-12	118	37	108	108	NUM
gsrj-12	118	38	georgetown	georgetown	PROPN
gsrj-12	118	39	scientific	scientific	PROPN
gsrj-12	118	40	research	research	NOUN
gsrj-12	118	41	journal	journal	PROPN
gsrj-12	118	42	https://doi.org/10.48091/uwyg8998	https://doi.org/10.48091/uwyg8998	PROPN
gsrj-12	118	43	references	reference	VERB
gsrj-12	118	44	epilepsy	epilepsy	PROPN
gsrj-12	118	45	.	.	PUNCT
gsrj-12	119	1	mayo	mayo	PROPN
gsrj-12	119	2	clinic	clinic	PROPN
gsrj-12	119	3	.	.	PUNCT
gsrj-12	120	1	https://www.mayoclinic.org/diseasesconditions/epilepsy/symptoms-causes/syc20350093	https://www.mayoclinic.org/diseasesconditions/epilepsy/symptoms-causes/syc20350093	PROPN
gsrj-12	120	2	.	.	PUNCT
gsrj-12	121	1	published	publish	VERB
gsrj-12	121	2	may	may	AUX
gsrj-12	121	3	5	5	NUM
gsrj-12	121	4	,	,	PUNCT
gsrj-12	121	5	2020	2020	NUM
gsrj-12	121	6	.	.	PUNCT
gsrj-12	122	1	accessed	access	VERB
gsrj-12	122	2	december	december	PROPN
gsrj-12	122	3	15	15	NUM
gsrj-12	122	4	,	,	PUNCT
gsrj-12	122	5	2020	2020	NUM
gsrj-12	122	6	.	.	PUNCT
gsrj-12	123	1	epilepsy	epilepsy	PROPN
gsrj-12	123	2	.	.	PUNCT
gsrj-12	124	1	world	world	PROPN
gsrj-12	124	2	health	health	PROPN
gsrj-12	124	3	organization	organization	NOUN
gsrj-12	124	4	.	.	PUNCT
gsrj-12	125	1	https://www.who.int/news-room/factsheets/detail/epilepsy	https://www.who.int/news-room/factsheets/detail/epilepsy	PROPN
gsrj-12	125	2	.	.	PUNCT
gsrj-12	126	1	published	publish	VERB
gsrj-12	126	2	june	june	PROPN
gsrj-12	126	3	20	20	NUM
gsrj-12	126	4	,	,	PUNCT
gsrj-12	126	5	2019	2019	NUM
gsrj-12	126	6	.	.	PUNCT
gsrj-12	127	1	accessed	access	VERB
gsrj-12	127	2	december	december	PROPN
gsrj-12	127	3	15	15	NUM
gsrj-12	127	4	,	,	PUNCT
gsrj-12	127	5	2020	2020	NUM
gsrj-12	127	6	.	.	PUNCT
gsrj-12	128	1	sirven	sirven	ADJ
gsrj-12	128	2	ji	ji	PROPN
gsrj-12	128	3	.	.	PROPN
gsrj-12	128	4	epilepsy	epilepsy	PROPN
gsrj-12	128	5	:	:	PUNCT
gsrj-12	128	6	a	a	DET
gsrj-12	128	7	spectrum	spectrum	NOUN
gsrj-12	128	8	disorder	disorder	NOUN
gsrj-12	128	9	.	.	PUNCT
gsrj-12	129	1	cold	cold	ADJ
gsrj-12	129	2	spring	spring	NOUN
gsrj-12	129	3	harbor	harbor	NOUN
gsrj-12	129	4	perspectives	perspective	NOUN
gsrj-12	129	5	in	in	ADP
gsrj-12	129	6	medicine	medicine	NOUN
gsrj-12	129	7	.	.	PUNCT
gsrj-12	130	1	2015;5(9	2015;5(9	NUM
gsrj-12	130	2	)	)	PUNCT
gsrj-12	130	3	.	.	PUNCT
gsrj-12	131	1	doi:10.1101	doi:10.1101	NOUN
gsrj-12	131	2	/	/	SYM
gsrj-12	131	3	cshperspect.a022848	cshperspect.a022848	NOUN
gsrj-12	131	4	wirrell	wirrell	PROPN
gsrj-12	131	5	e	e	NOUN
gsrj-12	131	6	,	,	PUNCT
gsrj-12	131	7	ed	ed	PROPN
gsrj-12	131	8	.	.	PUNCT
gsrj-12	131	9	drug	drug	NOUN
gsrj-12	131	10	-	-	PUNCT
gsrj-12	131	11	resistant	resistant	ADJ
gsrj-12	131	12	epilepsy	epilepsy	NOUN
gsrj-12	131	13	.	.	PUNCT
gsrj-12	132	1	epilepsy	epilepsy	PROPN
gsrj-12	132	2	foundation	foundation	PROPN
gsrj-12	132	3	.	.	PUNCT
gsrj-12	133	1	https://www.epilepsy.com/learn/drugresistant-epilepsy	https://www.epilepsy.com/learn/drugresistant-epilepsy	PROPN
gsrj-12	133	2	.	.	PUNCT
gsrj-12	134	1	published	publish	VERB
gsrj-12	134	2	october	october	PROPN
gsrj-12	134	3	5	5	NUM
gsrj-12	134	4	,	,	PUNCT
gsrj-12	134	5	2020	2020	NUM
gsrj-12	134	6	.	.	PUNCT
gsrj-12	135	1	accessed	access	VERB
gsrj-12	135	2	december	december	PROPN
gsrj-12	135	3	15	15	NUM
gsrj-12	135	4	,	,	PUNCT
gsrj-12	135	5	2020	2020	NUM
gsrj-12	135	6	.	.	PUNCT
gsrj-12	136	1	lazarowski	lazarowski	PROPN
gsrj-12	136	2	a	a	PROPN
gsrj-12	136	3	,	,	PUNCT
gsrj-12	136	4	massaro	massaro	PROPN
gsrj-12	136	5	m	m	PROPN
gsrj-12	136	6	,	,	PUNCT
gsrj-12	136	7	schteinschnaider	schteinschnaider	PROPN
gsrj-12	136	8	a	a	PRON
gsrj-12	136	9	,	,	PUNCT
gsrj-12	136	10	intruvini	intruvini	NOUN
gsrj-12	136	11	s	s	PART
gsrj-12	136	12	,	,	PUNCT
gsrj-12	136	13	sevlever	sevlever	VERB
gsrj-12	136	14	g	g	NOUN
gsrj-12	136	15	,	,	PUNCT
gsrj-12	136	16	rabinowicz	rabinowicz	ADJ
gsrj-12	136	17	a.	a.	NOUN
gsrj-12	136	18	neuronal	neuronal	ADJ
gsrj-12	136	19	mdr-1	mdr-1	NUM
gsrj-12	136	20	gene	gene	NOUN
gsrj-12	136	21	expression	expression	NOUN
gsrj-12	136	22	and	and	CCONJ
gsrj-12	136	23	persistent	persistent	ADJ
gsrj-12	136	24	low	low	ADJ
gsrj-12	136	25	levels	level	NOUN
gsrj-12	136	26	of	of	ADP
gsrj-12	136	27	anticonvulsants	anticonvulsant	NOUN
gsrj-12	136	28	in	in	ADP
gsrj-12	136	29	a	a	DET
gsrj-12	136	30	child	child	NOUN
gsrj-12	136	31	with	with	ADP
gsrj-12	136	32	refractory	refractory	NOUN
gsrj-12	136	33	epilepsy	epilepsy	NOUN
gsrj-12	136	34	.	.	PUNCT
gsrj-12	137	1	therapeutic	therapeutic	ADJ
gsrj-12	137	2	drug	drug	NOUN
gsrj-12	137	3	monitoring	monitoring	NOUN
gsrj-12	137	4	.	.	PUNCT
gsrj-12	138	1	2004;26(1):44	2004;26(1):44	NUM
gsrj-12	138	2	-	-	SYM
gsrj-12	138	3	46	46	NUM
gsrj-12	138	4	.	.	PUNCT
gsrj-12	138	5	doi:10.1097/00007691	doi:10.1097/00007691	NOUN
gsrj-12	138	6	-	-	PUNCT
gsrj-12	138	7	200402000	200402000	NUM
gsrj-12	138	8	-	-	PUNCT
gsrj-12	138	9	00010	00010	NUM
gsrj-12	138	10	french	french	PROPN
gsrj-12	138	11	ja	ja	PROPN
gsrj-12	138	12	.	.	PUNCT
gsrj-12	139	1	refractory	refractory	PROPN
gsrj-12	139	2	epilepsy	epilepsy	PROPN
gsrj-12	139	3	:	:	PUNCT
gsrj-12	139	4	clinical	clinical	ADJ
gsrj-12	139	5	overview	overview	NOUN
gsrj-12	139	6	.	.	PUNCT
gsrj-12	140	1	epilepsia	epilepsia	NOUN
gsrj-12	140	2	.	.	PUNCT
gsrj-12	141	1	2007;48(s1):3	2007;48(s1):3	NUM
gsrj-12	141	2	-	-	SYM
gsrj-12	141	3	7	7	NUM
gsrj-12	141	4	.	.	PUNCT
gsrj-12	141	5	doi:10.1111	doi:10.1111	ADJ
gsrj-12	141	6	/	/	SYM
gsrj-12	141	7	j.1528	j.1528	X
gsrj-12	141	8	-	-	SYM
gsrj-12	141	9	1167.2007.00992.x	1167.2007.00992.x	NUM
gsrj-12	141	10	lazarowski	lazarowski	NOUN
gsrj-12	141	11	a	a	PRON
gsrj-12	141	12	,	,	PUNCT
gsrj-12	141	13	czornyj	czornyj	NOUN
gsrj-12	141	14	l	l	NOUN
gsrj-12	141	15	,	,	PUNCT
gsrj-12	141	16	lubienieki	lubienieki	PROPN
gsrj-12	141	17	f	f	X
gsrj-12	141	18	,	,	PUNCT
gsrj-12	141	19	girardi	girardi	PROPN
gsrj-12	141	20	e	e	PROPN
gsrj-12	141	21	,	,	PUNCT
gsrj-12	141	22	vazquez	vazquez	PROPN
gsrj-12	141	23	s	s	PROPN
gsrj-12	141	24	,	,	PUNCT
gsrj-12	141	25	d'giano	d'giano	PROPN
gsrj-12	141	26	c.	c.	PROPN
gsrj-12	141	27	abc	abc	PROPN
gsrj-12	141	28	transporters	transporter	NOUN
gsrj-12	141	29	during	during	ADP
gsrj-12	141	30	epilepsy	epilepsy	NOUN
gsrj-12	141	31	and	and	CCONJ
gsrj-12	141	32	mechanisms	mechanism	NOUN
gsrj-12	141	33	underlying	underlie	VERB
gsrj-12	141	34	multidrug	multidrug	NOUN
gsrj-12	141	35	resistance	resistance	NOUN
gsrj-12	141	36	in	in	ADP
gsrj-12	141	37	refractory	refractory	NOUN
gsrj-12	141	38	epilepsy	epilepsy	NOUN
gsrj-12	141	39	.	.	PUNCT
gsrj-12	142	1	epilepsia	epilepsia	NOUN
gsrj-12	142	2	.	.	PUNCT
gsrj-12	143	1	2007;48(s5):140	2007;48(s5):140	NUM
gsrj-12	143	2	-	-	SYM
gsrj-12	143	3	149	149	NUM
gsrj-12	143	4	.	.	PUNCT
gsrj-12	144	1	doi:10.1111	doi:10.1111	PROPN
gsrj-12	144	2	/	/	SYM
gsrj-12	144	3	j.15281167.2007.01302.x	j.15281167.2007.01302.x	PROPN
gsrj-12	144	4	beis	beis	PROPN
gsrj-12	144	5	k.	k.	PROPN
gsrj-12	144	6	structural	structural	ADJ
gsrj-12	144	7	basis	basis	NOUN
gsrj-12	144	8	for	for	ADP
gsrj-12	144	9	the	the	DET
gsrj-12	144	10	mechanism	mechanism	NOUN
gsrj-12	144	11	of	of	ADP
gsrj-12	144	12	abc	abc	PROPN
gsrj-12	144	13	transporters	transporter	NOUN
gsrj-12	144	14	.	.	PUNCT
gsrj-12	145	1	biochemical	biochemical	ADJ
gsrj-12	145	2	society	society	NOUN
gsrj-12	145	3	transactions	transaction	NOUN
gsrj-12	145	4	.	.	PUNCT
gsrj-12	146	1	2015;43(5):889	2015;43(5):889	NUM
gsrj-12	146	2	-	-	PUNCT
gsrj-12	146	3	893	893	NUM
gsrj-12	146	4	.	.	PUNCT
gsrj-12	147	1	doi:10.1042	doi:10.1042	PROPN
gsrj-12	147	2	/	/	SYM
gsrj-12	147	3	bst20150047	bst20150047	ADJ
gsrj-12	147	4	tang	tang	PROPN
gsrj-12	147	5	f	f	X
gsrj-12	147	6	,	,	PUNCT
gsrj-12	147	7	hartz	hartz	PROPN
gsrj-12	147	8	ams	ams	PROPN
gsrj-12	147	9	,	,	PUNCT
gsrj-12	147	10	bauer	bauer	PROPN
gsrj-12	147	11	b.	b.	PROPN
gsrj-12	147	12	drugresistant	drugresistant	PROPN
gsrj-12	147	13	epilepsy	epilepsy	PROPN
gsrj-12	147	14	:	:	PUNCT
gsrj-12	147	15	multiple	multiple	ADJ
gsrj-12	147	16	hypotheses	hypothesis	NOUN
gsrj-12	147	17	,	,	PUNCT
gsrj-12	147	18	few	few	ADJ
gsrj-12	147	19	answers	answer	NOUN
gsrj-12	147	20	.	.	PUNCT
gsrj-12	148	1	frontiers	frontier	NOUN
gsrj-12	148	2	in	in	ADP
gsrj-12	148	3	neurology	neurology	NOUN
gsrj-12	148	4	.	.	PUNCT
gsrj-12	149	1	2017;8	2017;8	NOUN
gsrj-12	149	2	.	.	PUNCT
gsrj-12	149	3	doi:10.3389	doi:10.3389	PROPN
gsrj-12	149	4	/	/	SYM
gsrj-12	149	5	fneur.2017.00301	fneur.2017.00301	PROPN
gsrj-12	149	6	bauer	bauer	PROPN
gsrj-12	149	7	b	b	PROPN
gsrj-12	149	8	,	,	PUNCT
gsrj-12	149	9	schlichtiger	schlichtiger	PROPN
gsrj-12	149	10	j	j	PROPN
gsrj-12	149	11	,	,	PUNCT
gsrj-12	149	12	pekcec	pekcec	VERB
gsrj-12	149	13	a	a	DET
gsrj-12	149	14	,	,	PUNCT
gsrj-12	149	15	m.s	m.s	PROPN
gsrj-12	149	16	.	.	PUNCT
gsrj-12	149	17	a.	a.	NOUN
gsrj-12	150	1	the	the	DET
gsrj-12	150	2	blood	blood	NOUN
gsrj-12	150	3	-	-	PUNCT
gsrj-12	150	4	brain	brain	NOUN
gsrj-12	150	5	barrier	barrier	NOUN
gsrj-12	150	6	in	in	ADP
gsrj-12	150	7	epilepsy	epilepsy	NOUN
gsrj-12	150	8	.	.	PUNCT
gsrj-12	151	1	clinical	clinical	ADJ
gsrj-12	151	2	and	and	CCONJ
gsrj-12	151	3	genetic	genetic	ADJ
gsrj-12	151	4	aspects	aspect	NOUN
gsrj-12	151	5	of	of	ADP
gsrj-12	151	6	epilepsy	epilepsy	NOUN
gsrj-12	151	7	.	.	PUNCT
gsrj-12	152	1	september	september	PROPN
gsrj-12	152	2	2011	2011	NUM
gsrj-12	152	3	.	.	PUNCT
gsrj-12	153	1	doi:10.5772/21561	doi:10.5772/21561	PROPN
gsrj-12	154	1	sisodiya	sisodiya	PROPN
gsrj-12	154	2	s.	s.	PROPN
gsrj-12	154	3	etiology	etiology	PROPN
gsrj-12	154	4	and	and	CCONJ
gsrj-12	154	5	management	management	NOUN
gsrj-12	154	6	of	of	ADP
gsrj-12	154	7	refractory	refractory	NOUN
gsrj-12	154	8	epilepsies	epilepsy	NOUN
gsrj-12	154	9	.	.	PUNCT
gsrj-12	155	1	nature	nature	NOUN
gsrj-12	155	2	clinical	clinical	ADJ
gsrj-12	155	3	practice	practice	NOUN
gsrj-12	155	4	neurology	neurology	NOUN
gsrj-12	155	5	.	.	PUNCT
gsrj-12	156	1	2007;3(6):320	2007;3(6):320	NUM
gsrj-12	156	2	-	-	SYM
gsrj-12	156	3	330	330	NUM
gsrj-12	156	4	.	.	PUNCT
gsrj-12	157	1	doi:10.1038	doi:10.1038	NOUN
gsrj-12	157	2	/	/	SYM
gsrj-12	157	3	ncpneuro0521	ncpneuro0521	PROPN
gsrj-12	157	4	löscher	löscher	PROPN
gsrj-12	157	5	w	w	PROPN
gsrj-12	157	6	,	,	PUNCT
gsrj-12	157	7	potschka	potschka	PROPN
gsrj-12	157	8	h.	h.	PROPN
gsrj-12	157	9	blood	blood	NOUN
gsrj-12	157	10	-	-	PUNCT
gsrj-12	157	11	brain	brain	NOUN
gsrj-12	157	12	barrier	barrier	NOUN
gsrj-12	157	13	active	active	ADJ
gsrj-12	157	14	efflux	efflux	NOUN
gsrj-12	157	15	transporters	transporter	NOUN
gsrj-12	157	16	:	:	PUNCT
gsrj-12	157	17	atp	atp	NOUN
gsrj-12	157	18	-	-	PUNCT
gsrj-12	157	19	binding	bind	VERB
gsrj-12	157	20	cassette	cassette	NOUN
gsrj-12	157	21	gene	gene	NOUN
gsrj-12	157	22	family	family	NOUN
gsrj-12	157	23	.	.	PUNCT
gsrj-12	158	1	neurorx	neurorx	PROPN
gsrj-12	158	2	.	.	PUNCT
gsrj-12	159	1	2005;2(1):8698	2005;2(1):8698	X
gsrj-12	159	2	.	.	PUNCT
gsrj-12	159	3	doi:10.1602	doi:10.1602	PROPN
gsrj-12	159	4	/	/	SYM
gsrj-12	159	5	neurorx.2.1.86	neurorx.2.1.86	PROPN
gsrj-12	159	6	volk	volk	PROPN
gsrj-12	159	7	ha	ha	PROPN
gsrj-12	159	8	,	,	PUNCT
gsrj-12	159	9	löscher	löscher	PROPN
gsrj-12	159	10	w.	w.	PROPN
gsrj-12	159	11	multidrug	multidrug	VERB
gsrj-12	159	12	resistance	resistance	NOUN
gsrj-12	159	13	in	in	ADP
gsrj-12	159	14	epilepsy	epilepsy	NOUN
gsrj-12	159	15	:	:	PUNCT
gsrj-12	159	16	rats	rat	NOUN
gsrj-12	159	17	with	with	ADP
gsrj-12	159	18	drug	drug	NOUN
gsrj-12	159	19	-	-	PUNCT
gsrj-12	159	20	resistant	resistant	ADJ
gsrj-12	159	21	seizures	seizure	NOUN
gsrj-12	159	22	exhibit	exhibit	VERB
gsrj-12	159	23	enhanced	enhanced	ADJ
gsrj-12	159	24	brain	brain	NOUN
gsrj-12	159	25	expression	expression	NOUN
gsrj-12	159	26	of	of	ADP
gsrj-12	159	27	pglycoprotein	pglycoprotein	NOUN
gsrj-12	159	28	compared	compare	VERB
gsrj-12	159	29	with	with	ADP
gsrj-12	159	30	rats	rat	NOUN
gsrj-12	159	31	with	with	ADP
gsrj-12	159	32	drugresponsive	drugresponsive	ADJ
gsrj-12	159	33	seizures	seizure	NOUN
gsrj-12	159	34	.	.	PUNCT
gsrj-12	160	1	brain	brain	NOUN
gsrj-12	160	2	.	.	PUNCT
gsrj-12	161	1	2005;128(6):13581368	2005;128(6):13581368	NUM
gsrj-12	161	2	.	.	PUNCT
gsrj-12	161	3	doi:10.1093	doi:10.1093	NOUN
gsrj-12	161	4	/	/	SYM
gsrj-12	161	5	brain	brain	NOUN
gsrj-12	161	6	/	/	SYM
gsrj-12	161	7	awh437	awh437	VERB
gsrj-12	161	8	marchi	marchi	PROPN
gsrj-12	161	9	n	n	CCONJ
gsrj-12	161	10	,	,	PUNCT
gsrj-12	161	11	guiso	guiso	PROPN
gsrj-12	161	12	g	g	PROPN
gsrj-12	161	13	,	,	PUNCT
gsrj-12	161	14	rizzi	rizzi	PROPN
gsrj-12	161	15	m	m	PROPN
gsrj-12	161	16	,	,	PUNCT
gsrj-12	161	17	et	et	PROPN
gsrj-12	161	18	al	al	PROPN
gsrj-12	161	19	.	.	PUNCT
gsrj-12	162	1	a	a	DET
gsrj-12	162	2	pilot	pilot	NOUN
gsrj-12	162	3	study	study	NOUN
gsrj-12	162	4	on	on	ADP
gsrj-12	162	5	brain	brain	NOUN
gsrj-12	162	6	-	-	PUNCT
gsrj-12	162	7	to	to	ADP
gsrj-12	162	8	-	-	PUNCT
gsrj-12	162	9	plasma	plasma	NOUN
gsrj-12	162	10	partition	partition	NOUN
gsrj-12	162	11	of	of	ADP
gsrj-12	162	12	10,11dyhydro-10	10,11dyhydro-10	NUM
gsrj-12	162	13	-	-	PUNCT
gsrj-12	162	14	hydroxy-5hdibenzo(b	hydroxy-5hdibenzo(b	NOUN
gsrj-12	162	15	,	,	PUNCT
gsrj-12	162	16	f)azepine-5	f)azepine-5	NOUN
gsrj-12	162	17	-	-	PUNCT
gsrj-12	162	18	carboxamide	carboxamide	NOUN
gsrj-12	162	19	and	and	CCONJ
gsrj-12	162	20	mdr1	mdr1	PROPN
gsrj-12	162	21	brain	brain	NOUN
gsrj-12	162	22	expression	expression	NOUN
gsrj-12	162	23	in	in	ADP
gsrj-12	162	24	epilepsy	epilepsy	ADJ
gsrj-12	162	25	patients	patient	NOUN
gsrj-12	162	26	not	not	PART
gsrj-12	162	27	responding	respond	VERB
gsrj-12	162	28	to	to	ADP
gsrj-12	162	29	oxcarbazepine	oxcarbazepine	ADJ
gsrj-12	162	30	.	.	PUNCT
gsrj-12	163	1	epilepsia	epilepsia	NOUN
gsrj-12	163	2	.	.	PUNCT
gsrj-12	164	1	2005;46(10):1613	2005;46(10):1613	NUM
gsrj-12	164	2	-	-	SYM
gsrj-12	164	3	1619	1619	NUM
gsrj-12	164	4	.	.	PUNCT
gsrj-12	165	1	doi:10.1111	doi:10.1111	ADJ
gsrj-12	165	2	/	/	SYM
gsrj-12	165	3	j.15281167.2005.00265.x	j.15281167.2005.00265.x	PROPN
gsrj-12	165	4	vliet	vliet	PROPN
gsrj-12	165	5	eav	eav	PROPN
gsrj-12	165	6	,	,	PUNCT
gsrj-12	165	7	schaik	schaik	PROPN
gsrj-12	165	8	rv	rv	PROPN
gsrj-12	165	9	,	,	PUNCT
gsrj-12	165	10	edelbroek	edelbroek	ADJ
gsrj-12	165	11	pm	pm	NOUN
gsrj-12	165	12	,	,	PUNCT
gsrj-12	165	13	et	et	PROPN
gsrj-12	165	14	al	al	PROPN
gsrj-12	165	15	.	.	PUNCT
gsrj-12	165	16	region	region	NOUN
gsrj-12	165	17	-	-	PUNCT
gsrj-12	165	18	specific	specific	ADJ
gsrj-12	165	19	overexpression	overexpression	NOUN
gsrj-12	165	20	of	of	ADP
gsrj-12	165	21	pglycoprotein	pglycoprotein	NOUN
gsrj-12	165	22	at	at	ADP
gsrj-12	165	23	the	the	DET
gsrj-12	165	24	blood	blood	NOUN
gsrj-12	165	25	-	-	PUNCT
gsrj-12	165	26	brain	brain	NOUN
gsrj-12	165	27	barrier	barrier	NOUN
gsrj-12	165	28	affects	affect	VERB
gsrj-12	165	29	brain	brain	NOUN
gsrj-12	165	30	uptake	uptake	NOUN
gsrj-12	165	31	of	of	ADP
gsrj-12	165	32	phenytoin	phenytoin	NOUN
gsrj-12	165	33	in	in	ADP
gsrj-12	165	34	epileptic	epileptic	ADJ
gsrj-12	165	35	rats	rat	NOUN
gsrj-12	165	36	.	.	PUNCT
gsrj-12	166	1	journal	journal	NOUN
gsrj-12	166	2	of	of	ADP
gsrj-12	166	3	pharmacology	pharmacology	NOUN
gsrj-12	166	4	and	and	CCONJ
gsrj-12	166	5	experimental	experimental	ADJ
gsrj-12	166	6	therapeutics	therapeutic	NOUN
gsrj-12	166	7	.	.	PUNCT
gsrj-12	167	1	2007;322(1):141147	2007;322(1):141147	NUM
gsrj-12	167	2	.	.	PUNCT
gsrj-12	167	3	doi:10.1124	doi:10.1124	NOUN
gsrj-12	167	4	/	/	PUNCT
gsrj-12	168	1	jpet.107.121178	jpet.107.121178	PROPN
gsrj-12	168	2	srivalli	srivalli	PROPN
gsrj-12	168	3	kmr	kmr	PROPN
gsrj-12	168	4	,	,	PUNCT
gsrj-12	168	5	lakshmi	lakshmi	PROPN
gsrj-12	168	6	pk	pk	PROPN
gsrj-12	168	7	.	.	PROPN
gsrj-12	168	8	overview	overview	NOUN
gsrj-12	168	9	of	of	ADP
gsrj-12	168	10	pglycoprotein	pglycoprotein	ADJ
gsrj-12	168	11	inhibitors	inhibitor	NOUN
gsrj-12	168	12	:	:	PUNCT
gsrj-12	168	13	a	a	DET
gsrj-12	168	14	rational	rational	ADJ
gsrj-12	168	15	outlook	outlook	NOUN
gsrj-12	168	16	.	.	PUNCT
gsrj-12	169	1	brazilian	brazilian	ADJ
gsrj-12	169	2	journal	journal	PROPN
gsrj-12	169	3	of	of	ADP
gsrj-12	169	4	pharmaceutical	pharmaceutical	NOUN
gsrj-12	169	5	sciences	science	NOUN
gsrj-12	169	6	.	.	PUNCT
gsrj-12	170	1	2012;48(3):353	2012;48(3):353	NUM
gsrj-12	170	2	-	-	SYM
gsrj-12	170	3	367	367	NUM
gsrj-12	170	4	.	.	PUNCT
gsrj-12	171	1	doi:10.1590	doi:10.1590	PROPN
gsrj-12	171	2	/	/	SYM
gsrj-12	171	3	s198482502012000300002	s198482502012000300002	PROPN
gsrj-12	171	4	109	109	NUM
gsrj-12	171	5	georgetown	georgetown	PROPN
gsrj-12	171	6	scientific	scientific	PROPN
gsrj-12	171	7	research	research	NOUN
gsrj-12	171	8	journal	journal	PROPN
gsrj-12	171	9	https://doi.org/10.48091/uwyg8998	https://doi.org/10.48091/uwyg8998	PROPN
gsrj-12	171	10	amin	amin	PROPN
gsrj-12	171	11	ml	ml	PROPN
gsrj-12	171	12	.	.	PUNCT
gsrj-12	172	1	p	p	X
gsrj-12	172	2	-	-	PUNCT
gsrj-12	172	3	glycoprotein	glycoprotein	NOUN
gsrj-12	172	4	inhibition	inhibition	NOUN
gsrj-12	172	5	for	for	ADP
gsrj-12	172	6	optimal	optimal	ADJ
gsrj-12	172	7	drug	drug	NOUN
gsrj-12	172	8	delivery	delivery	NOUN
gsrj-12	172	9	.	.	PUNCT
gsrj-12	173	1	drug	drug	NOUN
gsrj-12	173	2	target	target	NOUN
gsrj-12	173	3	insights	insight	NOUN
gsrj-12	173	4	.	.	PUNCT
gsrj-12	174	1	2013;7:27	2013;7:27	NUM
gsrj-12	174	2	-	-	SYM
gsrj-12	174	3	34	34	NUM
gsrj-12	174	4	.	.	PUNCT
gsrj-12	174	5	doi:10.4137	doi:10.4137	NOUN
gsrj-12	174	6	/	/	SYM
gsrj-12	174	7	dti.s125192004;38(10):16311634	dti.s125192004;38(10):16311634	PROPN
gsrj-12	174	8	.	.	PUNCT
gsrj-12	175	1	doi:10.1345	doi:10.1345	PROPN
gsrj-12	175	2	/	/	SYM
gsrj-12	176	1	aph.1e068	aph.1e068	PROPN
gsrj-12	176	2	weidner	weidner	PROPN
gsrj-12	176	3	ld	ld	PROPN
gsrj-12	176	4	,	,	PUNCT
gsrj-12	176	5	fung	fung	PROPN
gsrj-12	176	6	kl	kl	PROPN
gsrj-12	176	7	,	,	PUNCT
gsrj-12	176	8	kannan	kannan	PROPN
gsrj-12	176	9	p	p	PROPN
gsrj-12	176	10	,	,	PUNCT
gsrj-12	176	11	et	et	PROPN
gsrj-12	176	12	al	al	PROPN
gsrj-12	176	13	.	.	PUNCT
gsrj-12	177	1	tariquidar	tariquidar	PROPN
gsrj-12	177	2	is	be	AUX
gsrj-12	177	3	an	an	DET
gsrj-12	177	4	inhibitor	inhibitor	NOUN
gsrj-12	177	5	and	and	CCONJ
gsrj-12	177	6	not	not	PART
gsrj-12	177	7	a	a	DET
gsrj-12	177	8	substrate	substrate	NOUN
gsrj-12	177	9	of	of	ADP
gsrj-12	177	10	human	human	NOUN
gsrj-12	177	11	and	and	CCONJ
gsrj-12	177	12	mouse	mouse	PROPN
gsrj-12	177	13	p	p	NOUN
gsrj-12	177	14	-	-	PUNCT
gsrj-12	177	15	glycoprotein	glycoprotein	NOUN
gsrj-12	177	16	.	.	PUNCT
gsrj-12	178	1	drug	drug	NOUN
gsrj-12	178	2	metabolism	metabolism	NOUN
gsrj-12	178	3	and	and	CCONJ
gsrj-12	178	4	disposition	disposition	NOUN
gsrj-12	178	5	.	.	PUNCT
gsrj-12	179	1	2015;44(2):275282	2015;44(2):275282	NUM
gsrj-12	179	2	.	.	PUNCT
gsrj-12	179	3	doi:10.1124	doi:10.1124	NOUN
gsrj-12	179	4	/	/	PUNCT
gsrj-12	180	1	dmd.115.067785	dmd.115.067785	PROPN
gsrj-12	180	2	vliet	vliet	PROPN
gsrj-12	180	3	eav	eav	PROPN
gsrj-12	180	4	,	,	PUNCT
gsrj-12	180	5	schaik	schaik	PROPN
gsrj-12	180	6	rv	rv	PROPN
gsrj-12	180	7	,	,	PUNCT
gsrj-12	180	8	edelbroek	edelbroek	ADJ
gsrj-12	180	9	pm	pm	NOUN
gsrj-12	180	10	,	,	PUNCT
gsrj-12	180	11	et	et	PROPN
gsrj-12	180	12	al	al	PROPN
gsrj-12	180	13	.	.	PROPN
gsrj-12	180	14	inhibition	inhibition	NOUN
gsrj-12	180	15	of	of	ADP
gsrj-12	180	16	the	the	DET
gsrj-12	180	17	multidrug	multidrug	NOUN
gsrj-12	180	18	transporter	transporter	NOUN
gsrj-12	180	19	pglycoprotein	pglycoprotein	NOUN
gsrj-12	180	20	improves	improves	AUX
gsrj-12	180	21	seizure	seizure	NOUN
gsrj-12	180	22	control	control	NOUN
gsrj-12	180	23	in	in	ADP
gsrj-12	180	24	phenytoin	phenytoin	NOUN
gsrj-12	180	25	-	-	PUNCT
gsrj-12	180	26	treated	treat	VERB
gsrj-12	180	27	chronic	chronic	ADJ
gsrj-12	180	28	epileptic	epileptic	ADJ
gsrj-12	180	29	rats	rat	NOUN
gsrj-12	180	30	.	.	PUNCT
gsrj-12	181	1	epilepsia	epilepsia	NOUN
gsrj-12	181	2	.	.	PUNCT
gsrj-12	182	1	2006;47(4):672	2006;47(4):672	NUM
gsrj-12	182	2	-	-	PUNCT
gsrj-12	182	3	680	680	NUM
gsrj-12	182	4	.	.	PUNCT
gsrj-12	183	1	doi:10.1111	doi:10.1111	ADJ
gsrj-12	183	2	/	/	SYM
gsrj-12	183	3	j.1528	j.1528	X
gsrj-12	183	4	-	-	SYM
gsrj-12	183	5	1167.2006.00496.x	1167.2006.00496.x	NUM
gsrj-12	183	6	brandt	brandt	PROPN
gsrj-12	183	7	c	c	PROPN
gsrj-12	183	8	,	,	PUNCT
gsrj-12	183	9	bethmann	bethmann	PROPN
gsrj-12	183	10	k	k	NOUN
gsrj-12	183	11	,	,	PUNCT
gsrj-12	183	12	gastens	gasten	NOUN
gsrj-12	183	13	am	be	AUX
gsrj-12	183	14	,	,	PUNCT
gsrj-12	183	15	löscher	löscher	X
gsrj-12	183	16	w.	w.	PROPN
gsrj-12	183	17	the	the	DET
gsrj-12	183	18	multidrug	multidrug	NOUN
gsrj-12	183	19	transporter	transporter	NOUN
gsrj-12	183	20	hypothesis	hypothesis	NOUN
gsrj-12	183	21	of	of	ADP
gsrj-12	183	22	drug	drug	NOUN
gsrj-12	183	23	resistance	resistance	NOUN
gsrj-12	183	24	in	in	ADP
gsrj-12	183	25	epilepsy	epilepsy	NOUN
gsrj-12	183	26	:	:	PUNCT
gsrj-12	183	27	proof	proof	NOUN
gsrj-12	183	28	-	-	PUNCT
gsrj-12	183	29	of	of	ADP
gsrj-12	183	30	-	-	PUNCT
gsrj-12	183	31	principle	principle	NOUN
gsrj-12	183	32	in	in	ADP
gsrj-12	183	33	a	a	DET
gsrj-12	183	34	rat	rat	NOUN
gsrj-12	183	35	model	model	NOUN
gsrj-12	183	36	of	of	ADP
gsrj-12	183	37	temporal	temporal	ADJ
gsrj-12	183	38	lobe	lobe	ADJ
gsrj-12	183	39	epilepsy	epilepsy	NOUN
gsrj-12	183	40	.	.	PUNCT
gsrj-12	184	1	neurobiology	neurobiology	NOUN
gsrj-12	184	2	of	of	ADP
gsrj-12	184	3	disease	disease	NOUN
gsrj-12	184	4	.	.	PUNCT
gsrj-12	185	1	2006;24(1):202	2006;24(1):202	NUM
gsrj-12	185	2	-	-	PUNCT
gsrj-12	185	3	211	211	NUM
gsrj-12	185	4	.	.	PUNCT
gsrj-12	185	5	doi:10.1016	doi:10.1016	PROPN
gsrj-12	185	6	/	/	SYM
gsrj-12	185	7	j.nbd.2006.06.014	j.nbd.2006.06.014	PROPN
gsrj-12	185	8	bauer	bauer	PROPN
gsrj-12	185	9	m	m	PROPN
gsrj-12	185	10	,	,	PUNCT
gsrj-12	185	11	zeitlinger	zeitlinger	PROPN
gsrj-12	185	12	m	m	PROPN
gsrj-12	185	13	,	,	PUNCT
gsrj-12	185	14	karch	karch	NOUN
gsrj-12	185	15	r	r	NOUN
gsrj-12	185	16	,	,	PUNCT
gsrj-12	185	17	et	et	PROPN
gsrj-12	185	18	al	al	PROPN
gsrj-12	185	19	.	.	PROPN
gsrj-12	185	20	pgpmediated	pgpmediate	VERB
gsrj-12	185	21	interaction	interaction	NOUN
gsrj-12	185	22	between	between	ADP
gsrj-12	185	23	(	(	PUNCT
gsrj-12	185	24	r)[11c]verapamil	r)[11c]verapamil	PROPN
gsrj-12	185	25	and	and	CCONJ
gsrj-12	185	26	tariquidar	tariquidar	VERB
gsrj-12	185	27	at	at	ADP
gsrj-12	185	28	the	the	DET
gsrj-12	185	29	human	human	ADJ
gsrj-12	185	30	blood	blood	NOUN
gsrj-12	185	31	–	–	PUNCT
gsrj-12	185	32	brain	brain	NOUN
gsrj-12	185	33	barrier	barrier	NOUN
gsrj-12	185	34	:	:	PUNCT
gsrj-12	185	35	a	a	DET
gsrj-12	185	36	comparison	comparison	NOUN
gsrj-12	185	37	with	with	ADP
gsrj-12	185	38	rat	rat	NOUN
gsrj-12	185	39	data	datum	NOUN
gsrj-12	185	40	.	.	PUNCT
gsrj-12	186	1	clinical	clinical	ADJ
gsrj-12	186	2	pharmacology	pharmacology	NOUN
gsrj-12	186	3	&	&	CCONJ
gsrj-12	186	4	therapeutics	therapeutic	NOUN
gsrj-12	186	5	.	.	PUNCT
gsrj-12	187	1	2011;91(2):227	2011;91(2):227	PROPN
gsrj-12	187	2	-	-	PUNCT
gsrj-12	187	3	233	233	NUM
gsrj-12	187	4	.	.	PUNCT
gsrj-12	188	1	doi:10.1038	doi:10.1038	NOUN
gsrj-12	188	2	/	/	SYM
gsrj-12	188	3	clpt.2011.217	clpt.2011.217	PROPN
gsrj-12	188	4	summers	summers	PROPN
gsrj-12	188	5	ma	ma	PROPN
gsrj-12	188	6	,	,	PUNCT
gsrj-12	188	7	moore	moore	PROPN
gsrj-12	188	8	jl	jl	PROPN
gsrj-12	188	9	,	,	PUNCT
gsrj-12	188	10	mcauley	mcauley	PROPN
gsrj-12	188	11	jw	jw	PROPN
gsrj-12	188	12	.	.	PROPN
gsrj-12	188	13	use	use	NOUN
gsrj-12	188	14	of	of	ADP
gsrj-12	188	15	verapamil	verapamil	NOUN
gsrj-12	188	16	as	as	ADP
gsrj-12	188	17	a	a	DET
gsrj-12	188	18	potential	potential	ADJ
gsrj-12	188	19	p	p	NOUN
gsrj-12	188	20	-	-	PUNCT
gsrj-12	188	21	glycoprotein	glycoprotein	NOUN
gsrj-12	188	22	inhibitor	inhibitor	NOUN
gsrj-12	188	23	in	in	ADP
gsrj-12	188	24	a	a	DET
gsrj-12	188	25	patient	patient	NOUN
gsrj-12	188	26	with	with	ADP
gsrj-12	188	27	refractory	refractory	NOUN
gsrj-12	188	28	epilepsy	epilepsy	NOUN
gsrj-12	188	29	.	.	PUNCT
gsrj-12	189	1	annals	annal	NOUN
gsrj-12	189	2	of	of	ADP
gsrj-12	189	3	pharmacotherapy	pharmacotherapy	NOUN
gsrj-12	189	4	.	.	PUNCT
gsrj-12	190	1	2004;38(10):1631	2004;38(10):1631	NUM
gsrj-12	190	2	-	-	SYM
gsrj-12	190	3	1634	1634	NUM
gsrj-12	190	4	.	.	PUNCT
gsrj-12	191	1	doi:10.1345	doi:10.1345	PROPN
gsrj-12	191	2	/	/	SYM
gsrj-12	192	1	aph.1e068	aph.1e068	VERB
gsrj-12	192	2	pusztai	pusztai	PROPN
gsrj-12	192	3	l	l	PROPN
gsrj-12	192	4	,	,	PUNCT
gsrj-12	192	5	wagner	wagner	PROPN
gsrj-12	192	6	p	p	PROPN
gsrj-12	192	7	,	,	PUNCT
gsrj-12	192	8	ibrahim	ibrahim	PROPN
gsrj-12	192	9	n	n	CCONJ
gsrj-12	192	10	,	,	PUNCT
gsrj-12	192	11	et	et	PROPN
gsrj-12	192	12	al	al	PROPN
gsrj-12	192	13	.	.	PROPN
gsrj-12	192	14	phase	phase	PROPN
gsrj-12	192	15	ii	ii	PROPN
gsrj-12	192	16	study	study	NOUN
gsrj-12	192	17	of	of	ADP
gsrj-12	192	18	tariquidar	tariquidar	PROPN
gsrj-12	192	19	,	,	PUNCT
gsrj-12	192	20	a	a	DET
gsrj-12	192	21	selective	selective	ADJ
gsrj-12	192	22	pglycoprotein	pglycoprotein	ADJ
gsrj-12	192	23	inhibitor	inhibitor	NOUN
gsrj-12	192	24	,	,	PUNCT
gsrj-12	192	25	in	in	ADP
gsrj-12	192	26	patients	patient	NOUN
gsrj-12	192	27	with	with	ADP
gsrj-12	192	28	chemotherapy	chemotherapy	NOUN
gsrj-12	192	29	-	-	ADJ
gsrj-12	192	30	resistant	resistant	ADJ
gsrj-12	192	31	,	,	PUNCT
gsrj-12	192	32	advanced	advanced	ADJ
gsrj-12	192	33	breast	breast	NOUN
gsrj-12	192	34	carcinoma	carcinoma	NOUN
gsrj-12	192	35	.	.	PUNCT
gsrj-12	193	1	cancer	cancer	NOUN
gsrj-12	193	2	.	.	PUNCT
gsrj-12	194	1	2005;104(4):682	2005;104(4):682	NOUN
gsrj-12	194	2	-	-	SYM
gsrj-12	194	3	691	691	NUM
gsrj-12	194	4	.	.	PUNCT
gsrj-12	195	1	doi:10.1002	doi:10.1002	NOUN
gsrj-12	195	2	/	/	SYM
gsrj-12	196	1	cncr.21227	cncr.21227	PROPN
gsrj-12	196	2	110	110	NUM
gsrj-12	196	3	biological	biological	ADJ
gsrj-12	196	4	and	and	CCONJ
gsrj-12	196	5	physical	physical	ADJ
gsrj-12	196	6	interactions	interaction	NOUN
gsrj-12	196	7	at	at	ADP
gsrj-12	196	8	local	local	ADJ
gsrj-12	196	9	ocean	ocean	NOUN
gsrj-12	196	10	scales	scale	NOUN
gsrj-12	196	11	:	:	PUNCT
gsrj-12	196	12	coupled	couple	VERB
gsrj-12	196	13	systems	system	NOUN
gsrj-12	196	14	determinants	determinant	NOUN
gsrj-12	196	15	of	of	ADP
gsrj-12	196	16	hepatocellular	hepatocellular	ADJ
gsrj-12	196	17	carcinoma	carcinoma	NOUN
gsrj-12	196	18	in	in	ADP
gsrj-12	196	19	the	the	DET
gsrj-12	196	20	united	united	PROPN
gsrj-12	196	21	states	states	PROPN
gsrj-12	196	22	:	:	PUNCT
gsrj-12	196	23	differences	difference	NOUN
gsrj-12	196	24	in	in	ADP
gsrj-12	196	25	risk	risk	NOUN
gsrj-12	196	26	factor	factor	NOUN
gsrj-12	196	27	and	and	CCONJ
gsrj-12	196	28	geneti	geneti	VERB
gsrj-12	196	29	the	the	DET
gsrj-12	196	30	preventative	preventative	ADJ
gsrj-12	196	31	and	and	CCONJ
gsrj-12	196	32	healing	healing	NOUN
gsrj-12	196	33	properties	property	NOUN
gsrj-12	196	34	of	of	ADP
gsrj-12	196	35	performing	perform	VERB
gsrj-12	196	36	arts	art	NOUN
gsrj-12	196	37	in	in	ADP
gsrj-12	196	38	female	female	ADJ
gsrj-12	196	39	genital	genital	ADJ
gsrj-12	196	40	mutilation	mutilation	NOUN
gsrj-12	196	41	policy	policy	NOUN
gsrj-12	196	42	brief	brief	NOUN
gsrj-12	196	43	:	:	PUNCT
gsrj-12	196	44	comparison	comparison	NOUN
gsrj-12	196	45	and	and	CCONJ
gsrj-12	196	46	recommendations	recommendation	NOUN
gsrj-12	196	47	for	for	ADP
gsrj-12	196	48	state	state	NOUN
gsrj-12	196	49	covid-19	covid-19	PROPN
gsrj-12	196	50	responses	response	NOUN
gsrj-12	196	51	of	of	ADP
gsrj-12	196	52	new	new	PROPN
gsrj-12	196	53	mexico	mexico	PROPN
gsrj-12	196	54	and	and	CCONJ
gsrj-12	196	55	utah	utah	PROPN
gsrj-12	196	56	interplay	interplay	NOUN
gsrj-12	196	57	of	of	ADP
gsrj-12	196	58	nicotine	nicotine	NOUN
gsrj-12	196	59	and	and	CCONJ
gsrj-12	196	60	social	social	ADJ
gsrj-12	196	61	stress	stress	NOUN
gsrj-12	196	62	mediate	mediate	VERB
gsrj-12	196	63	dopaminergic	dopaminergic	ADJ
gsrj-12	196	64	neuron	neuron	NOUN
gsrj-12	196	65	firing	fire	VERB
gsrj-12	196	66	in	in	ADP
gsrj-12	196	67	the	the	DET
gsrj-12	196	68	ventral	ventral	ADJ
gsrj-12	196	69	tegmental	tegmental	NOUN
gsrj-12	196	70	evaluating	evaluate	VERB
gsrj-12	196	71	the	the	DET
gsrj-12	196	72	efficacy	efficacy	NOUN
gsrj-12	196	73	of	of	ADP
gsrj-12	196	74	targeted	target	VERB
gsrj-12	196	75	inhibitor	inhibitor	NOUN
gsrj-12	196	76	therapeutics	therapeutic	NOUN
gsrj-12	196	77	for	for	ADP
gsrj-12	196	78	sonic	sonic	ADJ
gsrj-12	196	79	hedgehog	hedgehog	ADJ
gsrj-12	196	80	medulloblastoma	medulloblastoma	NOUN
gsrj-12	196	81	:	:	PUNCT
gsrj-12	196	82	signi	signi	ADJ
gsrj-12	196	83	refractory	refractory	NOUN
gsrj-12	196	84	epilepsy	epilepsy	NOUN
gsrj-12	196	85	:	:	PUNCT
gsrj-12	196	86	mechanisms	mechanism	NOUN
gsrj-12	196	87	of	of	ADP
gsrj-12	196	88	pharmacoresistance	pharmacoresistance	ADJ
gsrj-12	196	89	table	table	NOUN
gsrj-12	196	90	of	of	ADP
gsrj-12	196	91	contents	content	NOUN