id	sid	tid	token	lemma	pos
gs-1912	1	1	microsoft	microsoft	PROPN
gs-1912	1	2	word	word	NOUN
gs-1912	1	3	fullpdf05022023	fullpdf05022023	PROPN
gs-1912	1	4	georgian	georgian	PROPN
gs-1912	1	5	scientists/ქართველი	scientists/ქართველი	PROPN
gs-1912	1	6	მეცნიერები	მეცნიერები	NOUN
gs-1912	1	7	ტ.	ტ.	VERB
gs-1912	1	8	5	5	NUM
gs-1912	1	9	n	n	PRON
gs-1912	1	10	2	2	NUM
gs-1912	1	11	,	,	PUNCT
gs-1912	1	12	2023	2023	NUM
gs-1912	1	13	220	220	NUM
gs-1912	1	14	georgian	georgian	PROPN
gs-1912	1	15	scientists	scientist	NOUN
gs-1912	1	16	ქართველი	ქართველი	ADJ
gs-1912	1	17	მეცნიერები	მეცნიერები	PROPN
gs-1912	1	18	vol	vol	NOUN
gs-1912	1	19	.	.	PUNCT
gs-1912	2	1	5	5	NUM
gs-1912	2	2	issue	issue	NOUN
gs-1912	2	3	2	2	NUM
gs-1912	2	4	,	,	PUNCT
gs-1912	2	5	2023	2023	NUM
gs-1912	2	6	https://doi.org/10.52340/gs.2023.05.02.29	https://doi.org/10.52340/gs.2023.05.02.29	NUM
gs-1912	2	7	the	the	DET
gs-1912	2	8	permeability	permeability	NOUN
gs-1912	2	9	and	and	CCONJ
gs-1912	2	10	efflux	efflux	VERB
gs-1912	2	11	of	of	ADP
gs-1912	2	12	vinca	vinca	NOUN
gs-1912	2	13	alkaloids	alkaloid	NOUN
gs-1912	2	14	in	in	ADP
gs-1912	2	15	a	a	DET
gs-1912	2	16	caco-2	caco-2	NUM
gs-1912	2	17	cell	cell	NOUN
gs-1912	2	18	model	model	NOUN
gs-1912	2	19	lia	lia	PROPN
gs-1912	2	20	tsiklauri¹	tsiklauri¹	PROPN
gs-1912	2	21	*	*	PROPN
gs-1912	2	22	,	,	PUNCT
gs-1912	2	23	valentina	valentina	PROPN
gs-1912	2	24	vachnadze¹	vachnadze¹	PROPN
gs-1912	2	25	,	,	PUNCT
gs-1912	2	26	andreas	andreas	PROPN
gs-1912	2	27	bernkop	bernkop	PROPN
gs-1912	2	28	-	-	PUNCT
gs-1912	2	29	schnurch²	schnurch²	NOUN
gs-1912	2	30	¹i	¹i	NOUN
gs-1912	2	31	.	.	PUNCT
gs-1912	3	1	kutateladze	kutateladze	PROPN
gs-1912	3	2	institute	institute	PROPN
gs-1912	3	3	of	of	ADP
gs-1912	3	4	pharmacochemistry	pharmacochemistry	PROPN
gs-1912	3	5	,	,	PUNCT
gs-1912	3	6	tsmu	tsmu	PROPN
gs-1912	3	7	,	,	PUNCT
gs-1912	3	8	tbilisi	tbilisi	PROPN
gs-1912	3	9	,	,	PUNCT
gs-1912	3	10	georgia	georgia	PROPN
gs-1912	3	11	.	.	PUNCT
gs-1912	4	1	²institute	²institute	PROPN
gs-1912	4	2	of	of	ADP
gs-1912	4	3	pharmacy	pharmacy	NOUN
gs-1912	4	4	,	,	PUNCT
gs-1912	4	5	university	university	PROPN
gs-1912	4	6	of	of	ADP
gs-1912	4	7	innsbruck	innsbruck	PROPN
gs-1912	4	8	,	,	PUNCT
gs-1912	4	9	innsbruck	innsbruck	PROPN
gs-1912	4	10	,	,	PUNCT
gs-1912	4	11	austria	austria	PROPN
gs-1912	4	12	.	.	PUNCT
gs-1912	5	1	*	*	PUNCT
gs-1912	5	2	corresponding	correspond	VERB
gs-1912	5	3	author	author	NOUN
gs-1912	5	4	e	e	NOUN
gs-1912	5	5	-	-	NOUN
gs-1912	5	6	mail	mail	NOUN
gs-1912	5	7	:	:	PUNCT
gs-1912	5	8	l.tsiklauri@tsmu.edu	l.tsiklauri@tsmu.edu	NOUN
gs-1912	5	9	;	;	PUNCT
gs-1912	5	10	577418414	577418414	NUM
gs-1912	5	11	;	;	PUNCT
gs-1912	5	12	orcid	orcid	NOUN
gs-1912	5	13	0000	0000	NUM
gs-1912	5	14	-	-	PUNCT
gs-1912	5	15	0002	0002	NUM
gs-1912	5	16	-	-	PUNCT
gs-1912	5	17	7808	7808	NUM
gs-1912	5	18	-	-	SYM
gs-1912	5	19	5329	5329	NUM
gs-1912	5	20	andreas	andreas	PROPN
gs-1912	5	21	bernkop	bernkop	PROPN
gs-1912	5	22	-	-	PUNCT
gs-1912	5	23	schnurch	schnurch	NOUN
gs-1912	5	24	orcid	orcid	NOUN
gs-1912	5	25	0000	0000	NUM
gs-1912	5	26	-	-	PUNCT
gs-1912	5	27	0003	0003	NUM
gs-1912	5	28	-	-	PUNCT
gs-1912	5	29	4187	4187	NUM
gs-1912	5	30	-	-	PUNCT
gs-1912	5	31	8277	8277	NUM
gs-1912	5	32	abstract	abstract	ADJ
gs-1912	5	33	vinca	vinca	NOUN
gs-1912	5	34	alkaloids	alkaloid	NOUN
gs-1912	5	35	are	be	AUX
gs-1912	5	36	used	use	VERB
gs-1912	5	37	extensively	extensively	ADV
gs-1912	5	38	in	in	ADP
gs-1912	5	39	the	the	DET
gs-1912	5	40	treatment	treatment	NOUN
gs-1912	5	41	of	of	ADP
gs-1912	5	42	various	various	ADJ
gs-1912	5	43	diseases	disease	NOUN
gs-1912	5	44	and	and	CCONJ
gs-1912	5	45	despite	despite	SCONJ
gs-1912	5	46	their	their	PRON
gs-1912	5	47	usefulness	usefulness	NOUN
gs-1912	5	48	,	,	PUNCT
gs-1912	5	49	drug	drug	NOUN
gs-1912	5	50	resistance	resistance	NOUN
gs-1912	5	51	,	,	PUNCT
gs-1912	5	52	attributed	attribute	VERB
gs-1912	5	53	to	to	ADP
gs-1912	5	54	a	a	DET
gs-1912	5	55	number	number	NOUN
gs-1912	5	56	of	of	ADP
gs-1912	5	57	mechanisms	mechanism	NOUN
gs-1912	5	58	associated	associate	VERB
gs-1912	5	59	with	with	ADP
gs-1912	5	60	the	the	DET
gs-1912	5	61	multidrugresistance	multidrugresistance	NOUN
gs-1912	5	62	phenotype	phenotype	NOUN
gs-1912	5	63	including	include	VERB
gs-1912	5	64	overexpression	overexpression	NOUN
gs-1912	5	65	of	of	ADP
gs-1912	5	66	p	p	NOUN
gs-1912	5	67	-	-	PUNCT
gs-1912	5	68	glycoprotein	glycoprotein	NOUN
gs-1912	5	69	(	(	PUNCT
gs-1912	5	70	p	p	NOUN
gs-1912	5	71	-	-	PUNCT
gs-1912	5	72	gp	gp	NOUN
gs-1912	5	73	)	)	PUNCT
gs-1912	5	74	,	,	PUNCT
gs-1912	5	75	remains	remain	VERB
gs-1912	5	76	a	a	DET
gs-1912	5	77	serious	serious	ADJ
gs-1912	5	78	clinical	clinical	ADJ
gs-1912	5	79	problem	problem	NOUN
gs-1912	5	80	.	.	PUNCT
gs-1912	6	1	to	to	PART
gs-1912	6	2	identify	identify	VERB
gs-1912	6	3	the	the	DET
gs-1912	6	4	possible	possible	ADJ
gs-1912	6	5	role	role	NOUN
gs-1912	6	6	of	of	ADP
gs-1912	6	7	p	p	NOUN
gs-1912	6	8	-	-	PUNCT
gs-1912	6	9	gp	gp	NOUN
gs-1912	6	10	on	on	ADP
gs-1912	6	11	the	the	DET
gs-1912	6	12	intestinal	intestinal	ADJ
gs-1912	6	13	permeability	permeability	NOUN
gs-1912	6	14	of	of	ADP
gs-1912	6	15	anti	anti	ADJ
gs-1912	6	16	-	-	ADJ
gs-1912	6	17	arrhythmic	arrhythmic	ADJ
gs-1912	6	18	crude	crude	ADJ
gs-1912	6	19	alkaloids	alkaloid	NOUN
gs-1912	6	20	(	(	PUNCT
gs-1912	6	21	vingerbine	vingerbine	NOUN
gs-1912	6	22	)	)	PUNCT
gs-1912	6	23	from	from	ADP
gs-1912	6	24	vinca	vinca	ADJ
gs-1912	6	25	herbaceae	herbaceae	NOUN
gs-1912	6	26	,	,	PUNCT
gs-1912	6	27	caco-2	caco-2	NUM
gs-1912	6	28	cells	cell	NOUN
gs-1912	6	29	were	be	AUX
gs-1912	6	30	used	use	VERB
gs-1912	6	31	in	in	ADP
gs-1912	6	32	this	this	DET
gs-1912	6	33	study	study	NOUN
gs-1912	6	34	.	.	PUNCT
gs-1912	7	1	the	the	DET
gs-1912	7	2	four	four	NUM
gs-1912	7	3	vingerbine	vingerbine	NOUN
gs-1912	7	4	constituent	constituent	NOUN
gs-1912	7	5	alkaloids	alkaloid	NOUN
gs-1912	7	6	were	be	AUX
gs-1912	7	7	analyzed	analyze	VERB
gs-1912	7	8	by	by	ADP
gs-1912	7	9	high	high	ADJ
gs-1912	7	10	performance	performance	NOUN
gs-1912	7	11	liquid	liquid	NOUN
gs-1912	7	12	chromatography	chromatography	NOUN
gs-1912	7	13	(	(	PUNCT
gs-1912	7	14	hplc	hplc	PROPN
gs-1912	7	15	)	)	PUNCT
gs-1912	7	16	.	.	PUNCT
gs-1912	8	1	transport	transport	NOUN
gs-1912	8	2	parameters	parameter	NOUN
gs-1912	8	3	,	,	PUNCT
gs-1912	8	4	permeability	permeability	NOUN
gs-1912	8	5	coefficients	coefficient	NOUN
gs-1912	8	6	and	and	CCONJ
gs-1912	8	7	percent	percent	NOUN
gs-1912	8	8	transports	transport	NOUN
gs-1912	8	9	were	be	AUX
gs-1912	8	10	calculated	calculate	VERB
gs-1912	8	11	.	.	PUNCT
gs-1912	9	1	vingerbine	vingerbine	NOUN
gs-1912	9	2	constituent	constituent	NOUN
gs-1912	9	3	alkaloids	alkaloid	NOUN
gs-1912	9	4	displayed	display	VERB
gs-1912	9	5	the	the	DET
gs-1912	9	6	identical	identical	ADJ
gs-1912	9	7	tendency	tendency	NOUN
gs-1912	9	8	but	but	CCONJ
gs-1912	9	9	with	with	ADP
gs-1912	9	10	dissimilar	dissimilar	ADJ
gs-1912	9	11	degree	degree	NOUN
gs-1912	9	12	of	of	ADP
gs-1912	9	13	modulation	modulation	NOUN
gs-1912	9	14	in	in	ADP
gs-1912	9	15	absorptive	absorptive	ADJ
gs-1912	9	16	transport	transport	NOUN
gs-1912	9	17	direction	direction	NOUN
gs-1912	9	18	.	.	PUNCT
gs-1912	10	1	vincarine	vincarine	VERB
gs-1912	10	2	and	and	CCONJ
gs-1912	10	3	herbadine	herbadine	NOUN
gs-1912	10	4	demonstrated	demonstrate	VERB
gs-1912	10	5	higher	high	ADJ
gs-1912	10	6	-	-	PUNCT
gs-1912	10	7	level	level	NOUN
gs-1912	10	8	intestinal	intestinal	ADJ
gs-1912	10	9	transcellular	transcellular	NOUN
gs-1912	10	10	efflux	efflux	NOUN
gs-1912	10	11	;	;	PUNCT
gs-1912	10	12	the	the	DET
gs-1912	10	13	co	co	NOUN
gs-1912	10	14	-	-	NOUN
gs-1912	10	15	presence	presence	NOUN
gs-1912	10	16	of	of	ADP
gs-1912	10	17	verapamil	verapamil	NOUN
gs-1912	10	18	,	,	PUNCT
gs-1912	10	19	the	the	DET
gs-1912	10	20	absorptive	absorptive	ADJ
gs-1912	10	21	transport	transport	NOUN
gs-1912	10	22	of	of	ADP
gs-1912	10	23	alkaloids	alkaloid	NOUN
gs-1912	10	24	increased	increase	VERB
gs-1912	10	25	,	,	PUNCT
gs-1912	10	26	while	while	SCONJ
gs-1912	10	27	the	the	DET
gs-1912	10	28	secretory	secretory	NOUN
gs-1912	10	29	decreased	decrease	VERB
gs-1912	10	30	.	.	PUNCT
gs-1912	11	1	no	no	DET
gs-1912	11	2	asymmetric	asymmetric	ADJ
gs-1912	11	3	permeation	permeation	NOUN
gs-1912	11	4	was	be	AUX
gs-1912	11	5	observed	observe	VERB
gs-1912	11	6	for	for	ADP
gs-1912	11	7	herbamine	herbamine	ADJ
gs-1912	11	8	and	and	CCONJ
gs-1912	11	9	vincamajine	vincamajine	ADJ
gs-1912	11	10	.	.	PUNCT
gs-1912	12	1	the	the	DET
gs-1912	12	2	study	study	NOUN
gs-1912	12	3	suggests	suggest	VERB
gs-1912	12	4	the	the	DET
gs-1912	12	5	involvement	involvement	NOUN
gs-1912	12	6	for	for	ADP
gs-1912	12	7	multidrug	multidrug	NOUN
gs-1912	12	8	resistance	resistance	NOUN
gs-1912	12	9	-	-	PUNCT
gs-1912	12	10	associated	associate	VERB
gs-1912	12	11	proteins	protein	NOUN
gs-1912	12	12	(	(	PUNCT
gs-1912	12	13	mrps	mrps	PROPN
gs-1912	12	14	)	)	PUNCT
gs-1912	12	15	in	in	ADP
gs-1912	12	16	the	the	DET
gs-1912	12	17	intestinal	intestinal	ADJ
gs-1912	12	18	transcellular	transcellular	NOUN
gs-1912	12	19	efflux	efflux	NOUN
gs-1912	12	20	of	of	ADP
gs-1912	12	21	vincarine	vincarine	NOUN
gs-1912	12	22	and	and	CCONJ
gs-1912	12	23	herbadine	herbadine	ADJ
gs-1912	12	24	.	.	PUNCT
gs-1912	13	1	the	the	DET
gs-1912	13	2	further	further	ADJ
gs-1912	13	3	studies	study	NOUN
gs-1912	13	4	will	will	AUX
gs-1912	13	5	be	be	AUX
gs-1912	13	6	focused	focus	VERB
gs-1912	13	7	upon	upon	SCONJ
gs-1912	13	8	the	the	DET
gs-1912	13	9	screening	screen	VERB
gs-1912	13	10	appropriate	appropriate	ADJ
gs-1912	13	11	nanomedicine	nanomedicine	NOUN
gs-1912	13	12	-	-	PUNCT
gs-1912	13	13	based	base	VERB
gs-1912	13	14	strategies	strategy	NOUN
gs-1912	13	15	to	to	PART
gs-1912	13	16	combat	combat	VERB
gs-1912	13	17	mdr	mdr	PROPN
gs-1912	13	18	and	and	CCONJ
gs-1912	13	19	thus	thus	ADV
gs-1912	13	20	improve	improve	VERB
gs-1912	13	21	intestinal	intestinal	ADJ
gs-1912	13	22	absorption	absorption	NOUN
gs-1912	13	23	of	of	ADP
gs-1912	13	24	anti	anti	ADJ
gs-1912	13	25	-	-	ADJ
gs-1912	13	26	arrhythmic	arrhythmic	ADJ
gs-1912	13	27	alkaloids	alkaloid	NOUN
gs-1912	13	28	.	.	PUNCT
gs-1912	14	1	keywords	keyword	NOUN
gs-1912	14	2	:	:	PUNCT
gs-1912	14	3	vinca	vinca	NOUN
gs-1912	14	4	alkaloids	alkaloid	NOUN
gs-1912	14	5	,	,	PUNCT
gs-1912	14	6	indoline	indoline	NOUN
gs-1912	14	7	alkaloids	alkaloid	NOUN
gs-1912	14	8	,	,	PUNCT
gs-1912	14	9	vingerbine	vingerbine	NOUN
gs-1912	14	10	,	,	PUNCT
gs-1912	14	11	caco-2	caco-2	NUM
gs-1912	14	12	,	,	PUNCT
gs-1912	14	13	p	p	NOUN
gs-1912	14	14	-	-	PUNCT
gs-1912	14	15	glycoprotein	glycoprotein	NOUN
gs-1912	14	16	(	(	PUNCT
gs-1912	14	17	p	p	NOUN
gs-1912	14	18	-	-	PUNCT
gs-1912	14	19	gp	gp	NOUN
gs-1912	14	20	)	)	PUNCT
gs-1912	14	21	.	.	PUNCT
gs-1912	15	1	georgian	georgian	ADJ
gs-1912	15	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-1912	15	3	მეცნიერები	მეცნიერები	NOUN
gs-1912	15	4	ტ.	ტ.	VERB
gs-1912	15	5	5	5	NUM
gs-1912	15	6	n	n	DET
gs-1912	15	7	2	2	NUM
gs-1912	15	8	,	,	PUNCT
gs-1912	15	9	2023	2023	NUM
gs-1912	15	10	221	221	NUM
gs-1912	15	11	introduction	introduction	NOUN
gs-1912	15	12	vinca	vinca	NOUN
gs-1912	15	13	alkaloids	alkaloid	NOUN
gs-1912	15	14	(	(	PUNCT
gs-1912	15	15	periwinkle	periwinkle	NOUN
gs-1912	15	16	plant	plant	NOUN
gs-1912	15	17	,	,	PUNCT
gs-1912	15	18	catharanthus	catharanthus	NOUN
gs-1912	15	19	roseus	roseus	NOUN
gs-1912	15	20	)	)	PUNCT
gs-1912	15	21	are	be	AUX
gs-1912	15	22	an	an	DET
gs-1912	15	23	important	important	ADJ
gs-1912	15	24	group	group	NOUN
gs-1912	15	25	of	of	ADP
gs-1912	15	26	natural	natural	ADJ
gs-1912	15	27	products	product	NOUN
gs-1912	15	28	widely	widely	ADV
gs-1912	15	29	used	use	VERB
gs-1912	15	30	as	as	ADP
gs-1912	15	31	medicinal	medicinal	ADJ
gs-1912	15	32	agents	agent	NOUN
gs-1912	15	33	.	.	PUNCT
gs-1912	16	1	despite	despite	SCONJ
gs-1912	16	2	of	of	ADP
gs-1912	16	3	various	various	ADJ
gs-1912	16	4	therapeutical	therapeutical	ADJ
gs-1912	16	5	efficacies	efficacy	NOUN
gs-1912	16	6	such	such	ADJ
gs-1912	16	7	as	as	ADP
gs-1912	16	8	antiarrhythmic	antiarrhythmic	ADJ
gs-1912	16	9	,	,	PUNCT
gs-1912	16	10	hypotensive	hypotensive	ADJ
gs-1912	16	11	,	,	PUNCT
gs-1912	16	12	antitumor	antitumor	PROPN
gs-1912	16	13	,	,	PUNCT
gs-1912	16	14	these	these	DET
gs-1912	16	15	compounds	compound	NOUN
gs-1912	16	16	are	be	AUX
gs-1912	16	17	facing	face	VERB
gs-1912	16	18	problems	problem	NOUN
gs-1912	16	19	with	with	ADP
gs-1912	16	20	less	less	ADJ
gs-1912	16	21	oral	oral	ADJ
gs-1912	16	22	bioavailability	bioavailability	NOUN
gs-1912	16	23	and	and	CCONJ
gs-1912	16	24	interpatient	interpatient	NOUN
gs-1912	16	25	variability	variability	NOUN
gs-1912	16	26	(	(	PUNCT
gs-1912	16	27	1	1	NUM
gs-1912	16	28	)	)	PUNCT
gs-1912	16	29	.	.	PUNCT
gs-1912	17	1	it	it	PRON
gs-1912	17	2	was	be	AUX
gs-1912	17	3	found	find	VERB
gs-1912	17	4	out	out	ADP
gs-1912	17	5	that	that	SCONJ
gs-1912	17	6	the	the	DET
gs-1912	17	7	responsible	responsible	ADJ
gs-1912	17	8	for	for	ADP
gs-1912	17	9	a	a	DET
gs-1912	17	10	low	low	ADJ
gs-1912	17	11	oral	oral	ADJ
gs-1912	17	12	bioavailability	bioavailability	NOUN
gs-1912	17	13	of	of	ADP
gs-1912	17	14	alkaloids	alkaloid	NOUN
gs-1912	17	15	are	be	AUX
gs-1912	17	16	the	the	DET
gs-1912	17	17	atpbinding	atpbinding	NOUN
gs-1912	17	18	cassette	cassette	NOUN
gs-1912	17	19	(	(	PUNCT
gs-1912	17	20	abc	abc	PROPN
gs-1912	17	21	)	)	PUNCT
gs-1912	17	22	transporters	transporter	NOUN
gs-1912	17	23	such	such	ADJ
gs-1912	17	24	as	as	ADP
gs-1912	17	25	p	p	NOUN
gs-1912	17	26	-	-	PUNCT
gs-1912	17	27	glycoprotein	glycoprotein	NOUN
gs-1912	17	28	(	(	PUNCT
gs-1912	17	29	p	p	NOUN
gs-1912	17	30	-	-	PUNCT
gs-1912	17	31	gp	gp	NOUN
gs-1912	17	32	,	,	PUNCT
gs-1912	17	33	mdr1	mdr1	PROPN
gs-1912	17	34	)	)	PUNCT
gs-1912	17	35	,	,	PUNCT
gs-1912	17	36	by	by	ADP
gs-1912	17	37	pumping	pump	VERB
gs-1912	17	38	a	a	DET
gs-1912	17	39	variety	variety	NOUN
gs-1912	17	40	of	of	ADP
gs-1912	17	41	drugs	drug	NOUN
gs-1912	17	42	out	out	ADP
gs-1912	17	43	cells	cell	NOUN
gs-1912	17	44	at	at	ADP
gs-1912	17	45	the	the	DET
gs-1912	17	46	expense	expense	NOUN
gs-1912	17	47	of	of	ADP
gs-1912	17	48	atp	atp	NOUN
gs-1912	17	49	hydrolysis	hydrolysis	NOUN
gs-1912	17	50	(	(	PUNCT
gs-1912	17	51	2	2	NUM
gs-1912	17	52	)	)	PUNCT
gs-1912	17	53	.	.	PUNCT
gs-1912	18	1	in	in	ADP
gs-1912	18	2	comparison	comparison	NOUN
gs-1912	18	3	to	to	ADP
gs-1912	18	4	most	most	ADJ
gs-1912	18	5	other	other	ADJ
gs-1912	18	6	transport	transport	NOUN
gs-1912	18	7	proteins	protein	NOUN
gs-1912	18	8	that	that	PRON
gs-1912	18	9	recognize	recognize	VERB
gs-1912	18	10	specific	specific	ADJ
gs-1912	18	11	chemical	chemical	NOUN
gs-1912	18	12	substrates	substrate	NOUN
gs-1912	18	13	,	,	PUNCT
gs-1912	18	14	p	p	NOUN
gs-1912	18	15	-	-	PUNCT
gs-1912	18	16	gp	gp	NOUN
gs-1912	18	17	is	be	AUX
gs-1912	18	18	unusual	unusual	ADJ
gs-1912	18	19	since	since	SCONJ
gs-1912	18	20	it	it	PRON
gs-1912	18	21	pumps	pump	VERB
gs-1912	18	22	out	out	ADP
gs-1912	18	23	a	a	DET
gs-1912	18	24	variety	variety	NOUN
gs-1912	18	25	of	of	ADP
gs-1912	18	26	lipophilic	lipophilic	ADJ
gs-1912	18	27	and	and	CCONJ
gs-1912	18	28	cationic	cationic	ADJ
gs-1912	18	29	compounds	compound	NOUN
gs-1912	18	30	including	include	VERB
gs-1912	18	31	vinca	vinca	NOUN
gs-1912	18	32	alkaloids	alkaloid	NOUN
gs-1912	18	33	(	(	PUNCT
gs-1912	18	34	3	3	NUM
gs-1912	18	35	)	)	PUNCT
gs-1912	18	36	.	.	PUNCT
gs-1912	19	1	the	the	DET
gs-1912	19	2	molecular	molecular	ADJ
gs-1912	19	3	mechanisms	mechanism	NOUN
gs-1912	19	4	underlying	underlie	VERB
gs-1912	19	5	broad	broad	ADJ
gs-1912	19	6	substrate	substrate	NOUN
gs-1912	19	7	specificity	specificity	NOUN
gs-1912	19	8	of	of	ADP
gs-1912	19	9	this	this	DET
gs-1912	19	10	transporter	transporter	NOUN
gs-1912	19	11	are	be	AUX
gs-1912	19	12	generally	generally	ADV
gs-1912	19	13	unknown	unknown	ADJ
gs-1912	19	14	.	.	PUNCT
gs-1912	20	1	different	different	ADJ
gs-1912	20	2	attempts	attempt	NOUN
gs-1912	20	3	have	have	AUX
gs-1912	20	4	been	be	AUX
gs-1912	20	5	made	make	VERB
gs-1912	20	6	to	to	PART
gs-1912	20	7	find	find	VERB
gs-1912	20	8	a	a	DET
gs-1912	20	9	common	common	ADJ
gs-1912	20	10	set	set	NOUN
gs-1912	20	11	of	of	ADP
gs-1912	20	12	structural	structural	ADJ
gs-1912	20	13	and	and	CCONJ
gs-1912	20	14	functional	functional	ADJ
gs-1912	20	15	features	feature	NOUN
gs-1912	20	16	required	require	VERB
gs-1912	20	17	for	for	ADP
gs-1912	20	18	a	a	DET
gs-1912	20	19	substrate	substrate	NOUN
gs-1912	20	20	to	to	PART
gs-1912	20	21	interact	interact	VERB
gs-1912	20	22	with	with	ADP
gs-1912	20	23	pglycoprotein	pglycoprotein	NOUN
gs-1912	20	24	.	.	PUNCT
gs-1912	21	1	it	it	PRON
gs-1912	21	2	has	have	AUX
gs-1912	21	3	thus	thus	ADV
gs-1912	21	4	been	be	AUX
gs-1912	21	5	suggested	suggest	VERB
gs-1912	21	6	that	that	SCONJ
gs-1912	21	7	common	common	ADJ
gs-1912	21	8	property	property	NOUN
gs-1912	21	9	of	of	ADP
gs-1912	21	10	p	p	NOUN
gs-1912	21	11	-	-	PUNCT
gs-1912	21	12	glycoprotein	glycoprotein	NOUN
gs-1912	21	13	substrates	substrate	NOUN
gs-1912	21	14	is	be	AUX
gs-1912	21	15	their	their	PRON
gs-1912	21	16	relative	relative	ADJ
gs-1912	21	17	hydrophobic	hydrophobic	NOUN
gs-1912	21	18	nature	nature	NOUN
gs-1912	21	19	and	and	CCONJ
gs-1912	21	20	the	the	DET
gs-1912	21	21	minimum	minimum	ADJ
gs-1912	21	22	set	set	NOUN
gs-1912	21	23	of	of	ADP
gs-1912	21	24	structural	structural	ADJ
gs-1912	21	25	features	feature	NOUN
gs-1912	21	26	includes	include	VERB
gs-1912	21	27	a	a	DET
gs-1912	21	28	basic	basic	ADJ
gs-1912	21	29	nitrogen	nitrogen	NOUN
gs-1912	21	30	atom	atom	NOUN
gs-1912	21	31	and	and	CCONJ
gs-1912	21	32	planar	planar	ADJ
gs-1912	21	33	aromatic	aromatic	ADJ
gs-1912	21	34	domains	domain	NOUN
gs-1912	21	35	(	(	PUNCT
gs-1912	21	36	4	4	NUM
gs-1912	21	37	-	-	SYM
gs-1912	21	38	5	5	NUM
gs-1912	21	39	)	)	PUNCT
gs-1912	21	40	.	.	PUNCT
gs-1912	22	1	vinca	vinca	PROPN
gs-1912	22	2	herbacea	herbacea	PROPN
gs-1912	22	3	waldst	waldst	PROPN
gs-1912	22	4	et	et	PROPN
gs-1912	22	5	kit	kit	PROPN
gs-1912	22	6	,	,	PUNCT
gs-1912	22	7	the	the	DET
gs-1912	22	8	least	least	ADJ
gs-1912	22	9	investigated	investigate	VERB
gs-1912	22	10	among	among	ADP
gs-1912	22	11	the	the	DET
gs-1912	22	12	vinca	vinca	NOUN
gs-1912	22	13	species	specie	NOUN
gs-1912	22	14	,	,	PUNCT
gs-1912	22	15	is	be	AUX
gs-1912	22	16	widely	widely	ADV
gs-1912	22	17	distributed	distribute	VERB
gs-1912	22	18	in	in	ADP
gs-1912	22	19	georgia	georgia	PROPN
gs-1912	22	20	.	.	PUNCT
gs-1912	23	1	the	the	DET
gs-1912	23	2	detailed	detailed	ADJ
gs-1912	23	3	chemical	chemical	NOUN
gs-1912	23	4	investigation	investigation	NOUN
gs-1912	23	5	of	of	ADP
gs-1912	23	6	this	this	DET
gs-1912	23	7	plant	plant	NOUN
gs-1912	23	8	has	have	AUX
gs-1912	23	9	been	be	AUX
gs-1912	23	10	performed	perform	VERB
gs-1912	23	11	in	in	ADP
gs-1912	23	12	the	the	DET
gs-1912	23	13	laboratory	laboratory	NOUN
gs-1912	23	14	of	of	ADP
gs-1912	23	15	alkaloids	alkaloid	NOUN
gs-1912	23	16	of	of	ADP
gs-1912	23	17	i.	i.	PROPN
gs-1912	23	18	kutateladze	kutateladze	PROPN
gs-1912	23	19	iinstitute	iinstitute	PROPN
gs-1912	23	20	of	of	ADP
gs-1912	23	21	pharmacochemistry	pharmacochemistry	NOUN
gs-1912	23	22	tsmu	tsmu	NOUN
gs-1912	23	23	and	and	CCONJ
gs-1912	23	24	novel	novel	ADJ
gs-1912	23	25	natural	natural	ADJ
gs-1912	23	26	anti	anti	ADJ
gs-1912	23	27	-	-	ADJ
gs-1912	23	28	arrhythmic	arrhythmic	ADJ
gs-1912	23	29	component	component	NOUN
gs-1912	23	30	–	–	PUNCT
gs-1912	23	31	vingerbine	vingerbine	NOUN
gs-1912	23	32	,	,	PUNCT
gs-1912	23	33	has	have	AUX
gs-1912	23	34	been	be	AUX
gs-1912	23	35	isolated	isolate	VERB
gs-1912	23	36	from	from	ADP
gs-1912	23	37	its	its	PRON
gs-1912	23	38	aerial	aerial	ADJ
gs-1912	23	39	part	part	NOUN
gs-1912	23	40	(	(	PUNCT
gs-1912	23	41	6	6	NUM
gs-1912	23	42	-	-	SYM
gs-1912	23	43	8)	8)	NUM
gs-1912	23	44	.	.	PUNCT
gs-1912	24	1	vingerbine	vingerbine	NOUN
gs-1912	24	2	is	be	AUX
gs-1912	24	3	composed	compose	VERB
gs-1912	24	4	by	by	ADP
gs-1912	24	5	four	four	NUM
gs-1912	24	6	indoline	indoline	NOUN
gs-1912	24	7	alkaloids	alkaloid	NOUN
gs-1912	24	8	of	of	ADP
gs-1912	24	9	ajmaline	ajmaline	ADJ
gs-1912	24	10	series	series	NOUN
gs-1912	24	11	;	;	PUNCT
gs-1912	24	12	the	the	DET
gs-1912	24	13	pharmacological	pharmacological	ADJ
gs-1912	24	14	studies	study	NOUN
gs-1912	24	15	confirmed	confirm	VERB
gs-1912	24	16	that	that	SCONJ
gs-1912	24	17	its	its	PRON
gs-1912	24	18	therapeutic	therapeutic	ADJ
gs-1912	24	19	efficacy	efficacy	NOUN
gs-1912	24	20	is	be	AUX
gs-1912	24	21	generated	generate	VERB
gs-1912	24	22	by	by	ADP
gs-1912	24	23	specific	specific	ADJ
gs-1912	24	24	activity	activity	NOUN
gs-1912	24	25	of	of	ADP
gs-1912	24	26	each	each	DET
gs-1912	24	27	compounds	compound	NOUN
gs-1912	24	28	(	(	PUNCT
gs-1912	24	29	9	9	NUM
gs-1912	24	30	-	-	SYM
gs-1912	24	31	12	12	NUM
gs-1912	24	32	)	)	PUNCT
gs-1912	24	33	.	.	PUNCT
gs-1912	25	1	thus	thus	ADV
gs-1912	25	2	,	,	PUNCT
gs-1912	25	3	high	high	ADJ
gs-1912	25	4	intracellular	intracellular	ADJ
gs-1912	25	5	accumulation	accumulation	NOUN
gs-1912	25	6	of	of	ADP
gs-1912	25	7	these	these	DET
gs-1912	25	8	alkaloids	alkaloid	NOUN
gs-1912	25	9	will	will	AUX
gs-1912	25	10	provide	provide	VERB
gs-1912	25	11	maximal	maximal	ADJ
gs-1912	25	12	therapeutic	therapeutic	ADJ
gs-1912	25	13	effect	effect	NOUN
gs-1912	25	14	for	for	ADP
gs-1912	25	15	vingerbine	vingerbine	NOUN
gs-1912	25	16	.	.	PUNCT
gs-1912	26	1	since	since	SCONJ
gs-1912	26	2	vinca	vinca	NOUN
gs-1912	26	3	alkaloids	alkaloid	NOUN
gs-1912	26	4	are	be	AUX
gs-1912	26	5	known	know	VERB
gs-1912	26	6	to	to	PART
gs-1912	26	7	be	be	AUX
gs-1912	26	8	pumped	pump	VERB
gs-1912	26	9	out	out	ADP
gs-1912	26	10	by	by	ADP
gs-1912	26	11	p	p	NOUN
gs-1912	26	12	-	-	PUNCT
gs-1912	26	13	gp	gp	NOUN
gs-1912	26	14	,	,	PUNCT
gs-1912	26	15	the	the	DET
gs-1912	26	16	transport	transport	NOUN
gs-1912	26	17	of	of	ADP
gs-1912	26	18	vingerbine	vingerbine	NOUN
gs-1912	26	19	constituent	constituent	NOUN
gs-1912	26	20	alkaloids	alkaloid	NOUN
gs-1912	26	21	was	be	AUX
gs-1912	26	22	investigated	investigate	VERB
gs-1912	26	23	in	in	ADP
gs-1912	26	24	this	this	DET
gs-1912	26	25	study	study	NOUN
gs-1912	26	26	through	through	ADP
gs-1912	26	27	the	the	DET
gs-1912	26	28	caco-2	caco-2	NUM
gs-1912	26	29	cells	cell	NOUN
gs-1912	26	30	,	,	PUNCT
gs-1912	26	31	which	which	PRON
gs-1912	26	32	can	can	AUX
gs-1912	26	33	imitate	imitate	VERB
gs-1912	26	34	the	the	DET
gs-1912	26	35	transport	transport	NOUN
gs-1912	26	36	in	in	ADP
gs-1912	26	37	vitro	vitro	VERB
gs-1912	26	38	.	.	PUNCT
gs-1912	27	1	p	p	X
gs-1912	27	2	-	-	PUNCT
gs-1912	27	3	gp	gp	NOUN
gs-1912	27	4	is	be	AUX
gs-1912	27	5	known	know	VERB
gs-1912	27	6	to	to	PART
gs-1912	27	7	be	be	AUX
gs-1912	27	8	located	locate	VERB
gs-1912	27	9	in	in	ADP
gs-1912	27	10	the	the	DET
gs-1912	27	11	apical	apical	ADJ
gs-1912	27	12	(	(	PUNCT
gs-1912	27	13	brush	brush	NOUN
gs-1912	27	14	-	-	PUNCT
gs-1912	27	15	border	border	NOUN
gs-1912	27	16	)	)	PUNCT
gs-1912	27	17	membrane	membrane	NOUN
gs-1912	27	18	of	of	ADP
gs-1912	27	19	caco-2	caco-2	NUM
gs-1912	27	20	cells	cell	NOUN
gs-1912	27	21	and	and	CCONJ
gs-1912	27	22	presents	present	VERB
gs-1912	27	23	a	a	DET
gs-1912	27	24	major	major	ADJ
gs-1912	27	25	barrier	barrier	NOUN
gs-1912	27	26	to	to	ADP
gs-1912	27	27	the	the	DET
gs-1912	27	28	oral	oral	ADJ
gs-1912	27	29	delivery	delivery	NOUN
gs-1912	27	30	of	of	ADP
gs-1912	27	31	many	many	ADJ
gs-1912	27	32	structurally	structurally	ADV
gs-1912	27	33	diverse	diverse	ADJ
gs-1912	27	34	drugs	drug	NOUN
gs-1912	27	35	and	and	CCONJ
gs-1912	27	36	drugs	drug	NOUN
gs-1912	27	37	candidates	candidate	NOUN
gs-1912	27	38	(	(	PUNCT
gs-1912	27	39	13	13	NUM
gs-1912	27	40	-	-	SYM
gs-1912	27	41	14	14	NUM
gs-1912	27	42	)	)	PUNCT
gs-1912	27	43	.	.	PUNCT
gs-1912	28	1	materials	material	NOUN
gs-1912	28	2	and	and	CCONJ
gs-1912	28	3	methods	method	NOUN
gs-1912	28	4	materials	material	NOUN
gs-1912	28	5	.	.	PUNCT
gs-1912	29	1	dmso	dmso	NOUN
gs-1912	29	2	(	(	PUNCT
gs-1912	29	3	dimethyl	dimethyl	NOUN
gs-1912	29	4	sulfoxide	sulfoxide	NOUN
gs-1912	29	5	)	)	PUNCT
gs-1912	29	6	was	be	AUX
gs-1912	29	7	purchased	purchase	VERB
gs-1912	29	8	from	from	ADP
gs-1912	29	9	acros	acros	PROPN
gs-1912	29	10	organics	organic	NOUN
gs-1912	29	11	(	(	PUNCT
gs-1912	29	12	usa	usa	PROPN
gs-1912	29	13	)	)	PUNCT
gs-1912	29	14	.	.	PUNCT
gs-1912	30	1	sodium	sodium	NOUN
gs-1912	30	2	chloride	chloride	NOUN
gs-1912	30	3	(	(	PUNCT
gs-1912	30	4	nacl	nacl	NOUN
gs-1912	30	5	)	)	PUNCT
gs-1912	30	6	,	,	PUNCT
gs-1912	30	7	potassium	potassium	NOUN
gs-1912	30	8	chloride	chloride	NOUN
gs-1912	30	9	(	(	PUNCT
gs-1912	30	10	kcl	kcl	NOUN
gs-1912	30	11	)	)	PUNCT
gs-1912	30	12	and	and	CCONJ
gs-1912	30	13	glucose	glucose	NOUN
gs-1912	30	14	were	be	AUX
gs-1912	30	15	purchased	purchase	VERB
gs-1912	30	16	from	from	ADP
gs-1912	30	17	fluka	fluka	NOUN
gs-1912	30	18	chemical	chemical	NOUN
gs-1912	30	19	and	and	CCONJ
gs-1912	30	20	all	all	DET
gs-1912	30	21	other	other	ADJ
gs-1912	30	22	reagents	reagent	NOUN
gs-1912	30	23	and	and	CCONJ
gs-1912	30	24	solvents	solvent	NOUN
gs-1912	30	25	were	be	AUX
gs-1912	30	26	obtained	obtain	VERB
gs-1912	30	27	from	from	ADP
gs-1912	30	28	sigma	sigma	PROPN
gs-1912	30	29	(	(	PUNCT
gs-1912	30	30	st	st	PROPN
gs-1912	30	31	.	.	PROPN
gs-1912	30	32	louis	louis	PROPN
gs-1912	30	33	,	,	PUNCT
gs-1912	30	34	mo	mo	PROPN
gs-1912	30	35	,	,	PUNCT
gs-1912	30	36	austria	austria	PROPN
gs-1912	30	37	)	)	PUNCT
gs-1912	30	38	.	.	PUNCT
gs-1912	31	1	the	the	DET
gs-1912	31	2	chemicals	chemical	NOUN
gs-1912	31	3	were	be	AUX
gs-1912	31	4	of	of	ADP
gs-1912	31	5	analytical	analytical	ADJ
gs-1912	31	6	grade	grade	NOUN
gs-1912	31	7	and	and	CCONJ
gs-1912	31	8	solvents	solvent	NOUN
gs-1912	31	9	used	use	VERB
gs-1912	31	10	in	in	ADP
gs-1912	31	11	high	high	ADJ
gs-1912	31	12	-	-	PUNCT
gs-1912	31	13	performance	performance	NOUN
gs-1912	31	14	liquid	liquid	ADJ
gs-1912	31	15	chromatography	chromatography	NOUN
gs-1912	31	16	(	(	PUNCT
gs-1912	31	17	hplc	hplc	PROPN
gs-1912	31	18	)	)	PUNCT
gs-1912	31	19	were	be	AUX
gs-1912	31	20	of	of	ADP
gs-1912	31	21	hplc	hplc	NOUN
gs-1912	31	22	grade	grade	NOUN
gs-1912	31	23	.	.	PUNCT
gs-1912	32	1	vingerbine	vingerbine	NOUN
gs-1912	32	2	(	(	PUNCT
gs-1912	32	3	fig	fig	NOUN
gs-1912	32	4	.	.	NOUN
gs-1912	32	5	1	1	NUM
gs-1912	32	6	)	)	PUNCT
gs-1912	32	7	,	,	PUNCT
gs-1912	32	8	sum	sum	NOUN
gs-1912	32	9	of	of	ADP
gs-1912	32	10	indoline	indoline	NOUN
gs-1912	32	11	alkaloids	alkaloid	NOUN
gs-1912	32	12	was	be	AUX
gs-1912	32	13	obtained	obtain	VERB
gs-1912	32	14	according	accord	VERB
gs-1912	32	15	to	to	ADP
gs-1912	32	16	the	the	DET
gs-1912	32	17	procedures	procedure	NOUN
gs-1912	32	18	in	in	ADP
gs-1912	32	19	a	a	DET
gs-1912	32	20	previous	previous	ADJ
gs-1912	32	21	report	report	NOUN
gs-1912	32	22	(	(	PUNCT
gs-1912	32	23	10	10	NUM
gs-1912	32	24	,	,	PUNCT
gs-1912	32	25	15	15	NUM
gs-1912	32	26	)	)	PUNCT
gs-1912	32	27	.	.	PUNCT
gs-1912	33	1	vingerbine	vingerbine	NOUN
gs-1912	33	2	is	be	AUX
gs-1912	33	3	represented	represent	VERB
gs-1912	33	4	by	by	ADP
gs-1912	33	5	4	4	NUM
gs-1912	33	6	indoline	indoline	NOUN
gs-1912	33	7	alkaloids	alkaloid	NOUN
gs-1912	33	8	of	of	ADP
gs-1912	33	9	ajmaline	ajmaline	ADJ
gs-1912	33	10	series	series	NOUN
gs-1912	33	11	:	:	PUNCT
gs-1912	33	12	vincarine	vincarine	VERB
gs-1912	33	13	(	(	PUNCT
gs-1912	33	14	1	1	X
gs-1912	33	15	)	)	PUNCT
gs-1912	34	1	[	[	X
gs-1912	34	2	c₂₁h₂₄n₂o₃	c₂₁h₂₄n₂o₃	NOUN
gs-1912	34	3	(	(	PUNCT
gs-1912	34	4	353.3	353.3	NUM
gs-1912	34	5	)	)	PUNCT
gs-1912	34	6	,	,	PUNCT
gs-1912	34	7	m.p	m.p	PROPN
gs-1912	34	8	.	.	PROPN
gs-1912	34	9	264	264	NUM
gs-1912	34	10	2650c	2650c	NUM
gs-1912	34	11	,	,	PUNCT
gs-1912	34	12	[	[	X
gs-1912	34	13			X
gs-1912	34	14	]	]	X
gs-1912	34	15	d	d	X
gs-1912	34	16	+	+	NUM
gs-1912	34	17	13.75	13.75	NUM
gs-1912	34	18	±	±	NUM
gs-1912	34	19	0.80	0.80	NUM
gs-1912	34	20	(	(	PUNCT
gs-1912	34	21	ethanol	ethanol	NOUN
gs-1912	34	22	)	)	PUNCT
gs-1912	34	23	]	]	PUNCT
gs-1912	34	24	;	;	PUNCT
gs-1912	34	25	georgian	georgian	ADJ
gs-1912	34	26	scientists/ქართველი	scientists/ქართველი	NOUN
gs-1912	34	27	მეცნიერები	მეცნიერები	NOUN
gs-1912	34	28	ტ.	ტ.	VERB
gs-1912	34	29	5	5	NUM
gs-1912	34	30	n	n	PRON
gs-1912	34	31	2	2	NUM
gs-1912	34	32	,	,	PUNCT
gs-1912	34	33	2023	2023	NUM
gs-1912	34	34	222	222	NUM
gs-1912	34	35	vincamajine	vincamajine	NOUN
gs-1912	34	36	(	(	PUNCT
gs-1912	34	37	3	3	X
gs-1912	34	38	)	)	PUNCT
gs-1912	35	1	[	[	X
gs-1912	35	2	c₂₂h₂₆	c₂₂h₂₆	X
gs-1912	35	3	n₂o₃	n₂o₃	X
gs-1912	35	4	(	(	PUNCT
gs-1912	35	5	366	366	NUM
gs-1912	35	6	)	)	PUNCT
gs-1912	35	7	,	,	PUNCT
gs-1912	35	8	m.p	m.p	PROPN
gs-1912	35	9	.	.	PROPN
gs-1912	35	10	2262270c	2262270c	NUM
gs-1912	35	11	,	,	PUNCT
gs-1912	35	12	[	[	X
gs-1912	35	13			NOUN
gs-1912	35	14	]	]	X
gs-1912	35	15	d	d	X
gs-1912	35	16	21	21	NUM
gs-1912	35	17	±	±	NUM
gs-1912	35	18	0.10	0.10	NUM
gs-1912	35	19	(	(	PUNCT
gs-1912	35	20	chloroform	chloroform	NOUN
gs-1912	35	21	)	)	PUNCT
gs-1912	35	22	]	]	PUNCT
gs-1912	35	23	;	;	PUNCT
gs-1912	35	24	herbadine	herbadine	X
gs-1912	35	25	(	(	PUNCT
gs-1912	35	26	2	2	NUM
gs-1912	35	27	)	)	PUNCT
gs-1912	36	1	[	[	X
gs-1912	36	2	c₂₁h₂₄n₂o₄	c₂₁h₂₄n₂o₄	X
gs-1912	36	3	(	(	PUNCT
gs-1912	36	4	368	368	NUM
gs-1912	36	5	)	)	PUNCT
gs-1912	36	6	,	,	PUNCT
gs-1912	36	7	m.p	m.p	PROPN
gs-1912	36	8	.	.	PROPN
gs-1912	36	9	2032060c	2032060c	NUM
gs-1912	36	10	,	,	PUNCT
gs-1912	36	11	(	(	PUNCT
gs-1912	36	12	acetone	acetone	NOUN
gs-1912	36	13	)	)	PUNCT
gs-1912	36	14	]	]	PUNCT
gs-1912	36	15	;	;	PUNCT
gs-1912	36	16	herbamine	herbamine	ADJ
gs-1912	36	17	(	(	PUNCT
gs-1912	36	18	4	4	NUM
gs-1912	36	19	)	)	PUNCT
gs-1912	36	20	[	[	X
gs-1912	36	21	c₂₂h₂₆	c₂₂h₂₆	VERB
gs-1912	36	22	n₂o₄	n₂o₄	X
gs-1912	36	23	(	(	PUNCT
gs-1912	36	24	382	382	NUM
gs-1912	36	25	)	)	PUNCT
gs-1912	36	26	,	,	PUNCT
gs-1912	36	27	m.p	m.p	PROPN
gs-1912	36	28	.	.	PROPN
gs-1912	36	29	174	174	NUM
gs-1912	36	30	-	-	PUNCT
gs-1912	36	31	1760c	1760c	NUM
gs-1912	36	32	,	,	PUNCT
gs-1912	36	33	(	(	PUNCT
gs-1912	36	34	acetone	acetone	NOUN
gs-1912	36	35	)	)	PUNCT
gs-1912	36	36	]	]	PUNCT
gs-1912	36	37	(	(	PUNCT
gs-1912	36	38	16	16	NUM
gs-1912	36	39	)	)	PUNCT
gs-1912	36	40	.	.	PUNCT
gs-1912	37	1	fig.1	fig.1	PROPN
gs-1912	37	2	.	.	PUNCT
gs-1912	37	3	structures	structure	NOUN
gs-1912	37	4	of	of	ADP
gs-1912	37	5	vingerbine	vingerbine	NOUN
gs-1912	37	6	constituent	constituent	NOUN
gs-1912	37	7	alkaloids	alkaloid	NOUN
gs-1912	37	8	alkaloids	alkaloid	NOUN
gs-1912	37	9	.	.	PUNCT
gs-1912	37	10	in	in	ADP
gs-1912	37	11	-	-	PUNCT
gs-1912	37	12	vitro	vitro	X
gs-1912	37	13	transport	transport	NOUN
gs-1912	37	14	studies	study	NOUN
gs-1912	37	15	across	across	ADP
gs-1912	37	16	caco-2	caco-2	NUM
gs-1912	37	17	cell	cell	NOUN
gs-1912	37	18	monolayers	monolayer	NOUN
gs-1912	37	19	.	.	PUNCT
gs-1912	38	1	caco-2	caco-2	NUM
gs-1912	38	2	cell	cell	NOUN
gs-1912	38	3	monolayer	monolayer	NOUN
gs-1912	38	4	(	(	PUNCT
gs-1912	38	5	passage	passage	NOUN
gs-1912	38	6	number	number	NOUN
gs-1912	38	7	85	85	NUM
gs-1912	38	8	)	)	PUNCT
gs-1912	38	9	was	be	AUX
gs-1912	38	10	grown	grow	VERB
gs-1912	38	11	onto	onto	ADP
gs-1912	38	12	12	12	NUM
gs-1912	38	13	well	well	NOUN
gs-1912	38	14	transwell	transwell	NOUN
gs-1912	38	15	polycarbonate	polycarbonate	NOUN
gs-1912	38	16	membranes	membrane	NOUN
gs-1912	38	17	(	(	PUNCT
gs-1912	38	18	transwell	transwell	NOUN
gs-1912	38	19	®	®	NOUN
gs-1912	38	20	,	,	PUNCT
gs-1912	38	21	costar	costar	NOUN
gs-1912	38	22	,	,	PUNCT
gs-1912	38	23	0.4	0.4	NUM
gs-1912	38	24	µm	µm	ADP
gs-1912	38	25	pore	pore	ADJ
gs-1912	38	26	size	size	NOUN
gs-1912	38	27	,	,	PUNCT
gs-1912	38	28	12	12	NUM
gs-1912	38	29	mm	mm	NOUN
gs-1912	38	30	diameter	diameter	NOUN
gs-1912	38	31	)	)	PUNCT
gs-1912	38	32	according	accord	VERB
gs-1912	38	33	to	to	ADP
gs-1912	38	34	the	the	DET
gs-1912	38	35	protocol	protocol	NOUN
gs-1912	38	36	as	as	SCONJ
gs-1912	38	37	described	describe	VERB
gs-1912	38	38	by	by	ADP
gs-1912	38	39	sattler	sattler	PROPN
gs-1912	38	40	s.	s.	PROPN
gs-1912	38	41	et	et	PROPN
gs-1912	38	42	al	al	PROPN
gs-1912	38	43	.	.	PROPN
gs-1912	39	1	(	(	PUNCT
gs-1912	39	2	1997	1997	NUM
gs-1912	39	3	)	)	PUNCT
gs-1912	39	4	.	.	PUNCT
gs-1912	40	1	the	the	DET
gs-1912	40	2	cells	cell	NOUN
gs-1912	40	3	were	be	AUX
gs-1912	40	4	cultured	cultured	ADJ
gs-1912	40	5	in	in	ADP
gs-1912	40	6	minimum	minimum	ADJ
gs-1912	40	7	essential	essential	ADJ
gs-1912	40	8	medium	medium	NOUN
gs-1912	40	9	eagle	eagle	NOUN
gs-1912	40	10	(	(	PUNCT
gs-1912	40	11	mem	mem	ADJ
gs-1912	40	12	)	)	PUNCT
gs-1912	40	13	medium	medium	NOUN
gs-1912	40	14	supplemented	supplement	VERB
gs-1912	40	15	with	with	ADP
gs-1912	40	16	20	20	NUM
gs-1912	40	17	%	%	NOUN
gs-1912	40	18	fetal	fetal	ADJ
gs-1912	40	19	calf	calf	NOUN
gs-1912	40	20	serum	serum	NOUN
gs-1912	40	21	(	(	PUNCT
gs-1912	40	22	fcs	fcs	PROPN
gs-1912	40	23	)	)	PUNCT
gs-1912	40	24	.	.	PUNCT
gs-1912	41	1	the	the	DET
gs-1912	41	2	culture	culture	NOUN
gs-1912	41	3	medium	medium	NOUN
gs-1912	41	4	was	be	AUX
gs-1912	41	5	exchanged	exchange	VERB
gs-1912	41	6	every	every	DET
gs-1912	41	7	other	other	ADJ
gs-1912	41	8	day	day	NOUN
gs-1912	41	9	and	and	CCONJ
gs-1912	41	10	the	the	DET
gs-1912	41	11	cells	cell	NOUN
gs-1912	41	12	were	be	AUX
gs-1912	41	13	stored	store	VERB
gs-1912	41	14	in	in	ADP
gs-1912	41	15	a	a	DET
gs-1912	41	16	5	5	NUM
gs-1912	41	17	%	%	NOUN
gs-1912	41	18	co₂-incubator	co₂-incubator	NOUN
gs-1912	41	19	at	at	ADP
gs-1912	41	20	37	37	NUM
gs-1912	41	21	°	°	NOUN
gs-1912	41	22	c	c	NOUN
gs-1912	41	23	.	.	PUNCT
gs-1912	42	1	to	to	PART
gs-1912	42	2	evaluate	evaluate	VERB
gs-1912	42	3	the	the	DET
gs-1912	42	4	integrity	integrity	NOUN
gs-1912	42	5	of	of	ADP
gs-1912	42	6	caco-2	caco-2	NUM
gs-1912	42	7	cell	cell	NOUN
gs-1912	42	8	monolayers	monolayer	NOUN
gs-1912	42	9	,	,	PUNCT
gs-1912	42	10	transepithelial	transepithelial	ADJ
gs-1912	42	11	electrical	electrical	ADJ
gs-1912	42	12	resistance	resistance	NOUN
gs-1912	42	13	(	(	PUNCT
gs-1912	42	14	teer	teer	PROPN
gs-1912	42	15	)	)	PUNCT
gs-1912	42	16	was	be	AUX
gs-1912	42	17	measured	measure	VERB
gs-1912	42	18	with	with	ADP
gs-1912	42	19	evom	evom	NOUN
gs-1912	42	20	instrument	instrument	PROPN
gs-1912	42	21	(	(	PUNCT
gs-1912	42	22	world	world	NOUN
gs-1912	42	23	precision	precision	NOUN
gs-1912	42	24	instrument	instrument	NOUN
gs-1912	42	25	,	,	PUNCT
gs-1912	42	26	sarasota	sarasota	PROPN
gs-1912	42	27	,	,	PUNCT
gs-1912	42	28	fl	fl	PROPN
gs-1912	42	29	)	)	PUNCT
gs-1912	42	30	.	.	PUNCT
gs-1912	43	1	cell	cell	NOUN
gs-1912	43	2	monolayers	monolayer	NOUN
gs-1912	43	3	with	with	ADP
gs-1912	43	4	teer	teer	NOUN
gs-1912	43	5	values	value	NOUN
gs-1912	43	6	in	in	ADP
gs-1912	43	7	the	the	DET
gs-1912	43	8	range	range	NOUN
gs-1912	43	9	of	of	ADP
gs-1912	43	10	500	500	NUM
gs-1912	43	11	to	to	PART
gs-1912	43	12	600	600	NUM
gs-1912	43	13	ω	ω	NOUN
gs-1912	43	14	cm²	cm²	NOUN
gs-1912	43	15	were	be	AUX
gs-1912	43	16	included	include	VERB
gs-1912	43	17	in	in	ADP
gs-1912	43	18	the	the	DET
gs-1912	43	19	in	in	ADV
gs-1912	43	20	-	-	PUNCT
gs-1912	43	21	vitro	vitro	X
gs-1912	43	22	transport	transport	NOUN
gs-1912	43	23	studies	study	NOUN
gs-1912	43	24	only	only	ADV
gs-1912	43	25	.	.	PUNCT
gs-1912	44	1	on	on	ADP
gs-1912	44	2	the	the	DET
gs-1912	44	3	day	day	NOUN
gs-1912	44	4	of	of	ADP
gs-1912	44	5	experiment	experiment	NOUN
gs-1912	44	6	,	,	PUNCT
gs-1912	44	7	the	the	DET
gs-1912	44	8	cell	cell	NOUN
gs-1912	44	9	monolayers	monolayer	NOUN
gs-1912	44	10	were	be	AUX
gs-1912	44	11	rinsed	rinse	VERB
gs-1912	44	12	with	with	ADP
gs-1912	44	13	phosphate	phosphate	ADJ
gs-1912	44	14	buffer	buffer	NOUN
gs-1912	44	15	saline	saline	NOUN
gs-1912	44	16	(	(	PUNCT
gs-1912	44	17	ph	ph	NOUN
gs-1912	44	18	6.8	6.8	NUM
gs-1912	44	19	)	)	PUNCT
gs-1912	44	20	.	.	PUNCT
gs-1912	45	1	afterwards	afterwards	ADV
gs-1912	45	2	1	1	NUM
gs-1912	45	3	ml	ml	NOUN
gs-1912	45	4	of	of	ADP
gs-1912	45	5	hepes	hepe	NOUN
gs-1912	45	6	buffer	buffer	NOUN
gs-1912	45	7	was	be	AUX
gs-1912	45	8	added	add	VERB
gs-1912	45	9	to	to	ADP
gs-1912	45	10	the	the	DET
gs-1912	45	11	apical	apical	ADJ
gs-1912	45	12	and	and	CCONJ
gs-1912	45	13	1.5	1.5	NUM
gs-1912	45	14	ml	ml	NOUN
gs-1912	45	15	to	to	ADP
gs-1912	45	16	the	the	DET
gs-1912	45	17	basal	basal	ADJ
gs-1912	45	18	sides	side	NOUN
gs-1912	45	19	of	of	ADP
gs-1912	45	20	the	the	DET
gs-1912	45	21	transwell	transwell	NOUN
gs-1912	45	22	insert	insert	NOUN
gs-1912	45	23	and	and	CCONJ
gs-1912	45	24	after	after	ADP
gs-1912	45	25	a	a	DET
gs-1912	45	26	30	30	NUM
gs-1912	45	27	min	min	NOUN
gs-1912	45	28	equilibration	equilibration	NOUN
gs-1912	45	29	period	period	NOUN
gs-1912	45	30	in	in	ADP
gs-1912	45	31	5	5	NUM
gs-1912	45	32	%	%	NOUN
gs-1912	45	33	co₂	co₂	NOUN
gs-1912	45	34	incubator	incubator	NOUN
gs-1912	45	35	,	,	PUNCT
gs-1912	45	36	teer	teer	PROPN
gs-1912	45	37	was	be	AUX
gs-1912	45	38	measured	measure	VERB
gs-1912	45	39	to	to	PART
gs-1912	45	40	ensure	ensure	VERB
gs-1912	45	41	integrity	integrity	NOUN
gs-1912	45	42	of	of	ADP
gs-1912	45	43	the	the	DET
gs-1912	45	44	caco-2	caco-2	NUM
gs-1912	45	45	cell	cell	NOUN
gs-1912	45	46	monolayers	monolayer	NOUN
gs-1912	45	47	.	.	PUNCT
gs-1912	46	1	vingerbine	vingerbine	NOUN
gs-1912	46	2	stock	stock	NOUN
gs-1912	46	3	solution	solution	NOUN
gs-1912	46	4	in	in	ADP
gs-1912	46	5	a	a	DET
gs-1912	46	6	final	final	ADJ
gs-1912	46	7	concentration	concentration	NOUN
gs-1912	46	8	of	of	ADP
gs-1912	46	9	0.02	0.02	NUM
gs-1912	46	10	%	%	NOUN
gs-1912	46	11	(	(	PUNCT
gs-1912	46	12	w	w	NOUN
gs-1912	46	13	/	/	SYM
gs-1912	46	14	v	v	NOUN
gs-1912	46	15	)	)	PUNCT
gs-1912	46	16	was	be	AUX
gs-1912	46	17	added	add	VERB
gs-1912	46	18	to	to	ADP
gs-1912	46	19	the	the	DET
gs-1912	46	20	apical	apical	ADJ
gs-1912	46	21	side	side	NOUN
gs-1912	46	22	for	for	ADP
gs-1912	46	23	absorptive	absorptive	ADJ
gs-1912	46	24	(	(	PUNCT
gs-1912	46	25	ap	ap	NOUN
gs-1912	46	26	to	to	PART
gs-1912	46	27	bl	bl	VERB
gs-1912	46	28	)	)	PUNCT
gs-1912	46	29	transport	transport	NOUN
gs-1912	46	30	.	.	PUNCT
gs-1912	47	1	respectively	respectively	ADV
gs-1912	47	2	the	the	DET
gs-1912	47	3	same	same	ADJ
gs-1912	47	4	concentration	concentration	NOUN
gs-1912	47	5	of	of	ADP
gs-1912	47	6	dmso	dmso	NOUN
gs-1912	47	7	was	be	AUX
gs-1912	47	8	made	make	VERB
gs-1912	47	9	in	in	ADP
gs-1912	47	10	basolateral	basolateral	ADJ
gs-1912	47	11	side	side	NOUN
gs-1912	47	12	.	.	PUNCT
gs-1912	48	1	200	200	NUM
gs-1912	48	2	µl	µl	ADP
gs-1912	48	3	samples	sample	NOUN
gs-1912	48	4	were	be	AUX
gs-1912	48	5	withdrawn	withdraw	VERB
gs-1912	48	6	from	from	ADP
gs-1912	48	7	the	the	DET
gs-1912	48	8	acceptor	acceptor	NOUN
gs-1912	48	9	sides	side	NOUN
gs-1912	48	10	every	every	DET
gs-1912	48	11	60	60	NUM
gs-1912	48	12	min	min	NOUN
gs-1912	48	13	over	over	ADP
gs-1912	48	14	a	a	DET
gs-1912	48	15	time	time	NOUN
gs-1912	48	16	period	period	NOUN
gs-1912	48	17	of	of	ADP
gs-1912	48	18	3	3	NUM
gs-1912	48	19	h	h	NOUN
gs-1912	48	20	and	and	CCONJ
gs-1912	48	21	immediately	immediately	ADV
gs-1912	48	22	replaced	replace	VERB
gs-1912	48	23	by	by	ADP
gs-1912	48	24	2	2	NUM
gs-1912	48	25	%	%	NOUN
gs-1912	48	26	dmso	dmso	ADJ
gs-1912	48	27	solution	solution	NOUN
gs-1912	48	28	in	in	ADP
gs-1912	48	29	incubation	incubation	NOUN
gs-1912	48	30	medium	medium	NOUN
gs-1912	48	31	equilibrated	equilibrate	VERB
gs-1912	48	32	at	at	ADP
gs-1912	48	33	37	37	NUM
gs-1912	48	34	°	°	NOUN
gs-1912	48	35	c	c	NOUN
gs-1912	48	36	.	.	PUNCT
gs-1912	49	1	the	the	DET
gs-1912	49	2	final	final	ADJ
gs-1912	49	3	concentration	concentration	NOUN
gs-1912	49	4	of	of	ADP
gs-1912	49	5	dmso	dmso	NOUN
gs-1912	49	6	was	be	AUX
gs-1912	49	7	less	less	ADJ
gs-1912	49	8	than	than	ADP
gs-1912	49	9	2	2	NUM
gs-1912	49	10	%	%	NOUN
gs-1912	49	11	in	in	ADP
gs-1912	49	12	all	all	DET
gs-1912	49	13	experiments	experiment	NOUN
gs-1912	49	14	,	,	PUNCT
gs-1912	49	15	which	which	PRON
gs-1912	49	16	did	do	AUX
gs-1912	49	17	not	not	PART
gs-1912	49	18	have	have	VERB
gs-1912	49	19	any	any	DET
gs-1912	49	20	detectable	detectable	ADJ
gs-1912	49	21	effect	effect	NOUN
gs-1912	49	22	on	on	ADP
gs-1912	49	23	the	the	DET
gs-1912	49	24	cell	cell	NOUN
gs-1912	49	25	monolayers	monolayer	NOUN
gs-1912	49	26	.	.	PUNCT
gs-1912	50	1	inhibition	inhibition	NOUN
gs-1912	50	2	of	of	ADP
gs-1912	50	3	transport	transport	NOUN
gs-1912	50	4	.	.	PUNCT
gs-1912	51	1	inhibition	inhibition	NOUN
gs-1912	51	2	of	of	ADP
gs-1912	51	3	vinca	vinca	NOUN
gs-1912	51	4	alkaloids	alkaloid	NOUN
gs-1912	51	5	transport	transport	NOUN
gs-1912	51	6	was	be	AUX
gs-1912	51	7	tasted	taste	VERB
gs-1912	51	8	with	with	ADP
gs-1912	51	9	known	know	VERB
gs-1912	51	10	p	p	NOUN
gs-1912	51	11	-	-	PUNCT
gs-1912	51	12	gp	gp	NOUN
gs-1912	51	13	inhibitor	inhibitor	NOUN
gs-1912	51	14	verapamil	verapamil	NOUN
gs-1912	51	15	(	(	PUNCT
gs-1912	51	16	100	100	NUM
gs-1912	51	17	µm	µm	NOUN
gs-1912	51	18	)	)	PUNCT
gs-1912	51	19	,	,	PUNCT
gs-1912	51	20	which	which	PRON
gs-1912	51	21	was	be	AUX
gs-1912	51	22	freshly	freshly	ADV
gs-1912	51	23	prepared	prepare	VERB
gs-1912	51	24	by	by	ADP
gs-1912	51	25	dissolving	dissolve	VERB
gs-1912	51	26	in	in	ADP
gs-1912	51	27	incubation	incubation	NOUN
gs-1912	51	28	medium	medium	NOUN
gs-1912	51	29	and	and	CCONJ
gs-1912	51	30	applied	apply	VERB
gs-1912	51	31	in	in	ADP
gs-1912	51	32	either	either	CCONJ
gs-1912	51	33	the	the	DET
gs-1912	51	34	apical	apical	ADJ
gs-1912	51	35	or	or	CCONJ
gs-1912	51	36	basolateral	basolateral	ADJ
gs-1912	51	37	side	side	NOUN
gs-1912	51	38	.	.	PUNCT
gs-1912	52	1	unidirectional	unidirectional	ADJ
gs-1912	52	2	and	and	CCONJ
gs-1912	52	3	net	net	ADJ
gs-1912	52	4	flux	flux	NOUN
gs-1912	52	5	of	of	ADP
gs-1912	52	6	vingerbine	vingerbine	NOUN
gs-1912	52	7	was	be	AUX
gs-1912	52	8	measured	measure	VERB
gs-1912	52	9	in	in	ADP
gs-1912	52	10	the	the	DET
gs-1912	52	11	presence	presence	NOUN
gs-1912	52	12	and	and	CCONJ
gs-1912	52	13	absence	absence	NOUN
gs-1912	52	14	of	of	ADP
gs-1912	52	15	verapamil	verapamil	NOUN
gs-1912	52	16	.	.	PUNCT
gs-1912	53	1	after	after	ADP
gs-1912	53	2	30	30	NUM
gs-1912	53	3	min	min	NOUN
gs-1912	53	4	equilibration	equilibration	NOUN
gs-1912	53	5	the	the	DET
gs-1912	53	6	drug	drug	NOUN
gs-1912	53	7	stock	stock	NOUN
gs-1912	53	8	solution	solution	NOUN
gs-1912	53	9	was	be	AUX
gs-1912	53	10	added	add	VERB
gs-1912	53	11	giving	give	VERB
gs-1912	53	12	a	a	DET
gs-1912	53	13	final	final	ADJ
gs-1912	53	14	concentration	concentration	NOUN
gs-1912	53	15	of	of	ADP
gs-1912	53	16	0.02	0.02	NUM
gs-1912	53	17	%	%	NOUN
gs-1912	53	18	(	(	PUNCT
gs-1912	53	19	w	w	NOUN
gs-1912	53	20	/	/	SYM
gs-1912	53	21	v	v	NOUN
gs-1912	53	22	)	)	PUNCT
gs-1912	53	23	to	to	ADP
gs-1912	53	24	the	the	DET
gs-1912	53	25	apical	apical	ADJ
gs-1912	53	26	side	side	NOUN
gs-1912	53	27	for	for	ADP
gs-1912	53	28	absorptive	absorptive	ADJ
gs-1912	53	29	(	(	PUNCT
gs-1912	53	30	ap	ap	PROPN
gs-1912	53	31	georgian	georgian	PROPN
gs-1912	53	32	scientists/ქართველი	scientists/ქართველი	PROPN
gs-1912	53	33	მეცნიერები	მეცნიერები	NOUN
gs-1912	53	34	ტ.	ტ.	VERB
gs-1912	53	35	5	5	NUM
gs-1912	53	36	n	n	PRON
gs-1912	53	37	2	2	NUM
gs-1912	53	38	,	,	PUNCT
gs-1912	53	39	2023	2023	NUM
gs-1912	53	40	223	223	NUM
gs-1912	53	41	to	to	PART
gs-1912	53	42	bl	bl	VERB
gs-1912	53	43	)	)	PUNCT
gs-1912	53	44	/	/	SYM
gs-1912	53	45	or	or	CCONJ
gs-1912	53	46	basolateral	basolateral	NOUN
gs-1912	53	47	for	for	ADP
gs-1912	53	48	secretory	secretory	NOUN
gs-1912	53	49	(	(	PUNCT
gs-1912	53	50	bl	bl	INTJ
gs-1912	53	51	to	to	PART
gs-1912	53	52	ap	ap	ADJ
gs-1912	53	53	)	)	PUNCT
gs-1912	53	54	transport	transport	NOUN
gs-1912	53	55	.	.	PUNCT
gs-1912	54	1	then	then	ADV
gs-1912	54	2	the	the	DET
gs-1912	54	3	experiment	experiment	NOUN
gs-1912	54	4	was	be	AUX
gs-1912	54	5	performed	perform	VERB
gs-1912	54	6	as	as	ADP
gs-1912	54	7	described	describe	VERB
gs-1912	54	8	above	above	ADV
gs-1912	54	9	.	.	PUNCT
gs-1912	55	1	teer	teer	PROPN
gs-1912	55	2	was	be	AUX
gs-1912	55	3	measured	measure	VERB
gs-1912	55	4	every	every	DET
gs-1912	55	5	hour	hour	NOUN
gs-1912	55	6	.	.	PUNCT
gs-1912	56	1	the	the	DET
gs-1912	56	2	amount	amount	NOUN
gs-1912	56	3	of	of	ADP
gs-1912	56	4	transported	transport	VERB
gs-1912	56	5	vinca	vinca	NOUN
gs-1912	56	6	alkaloids	alkaloid	NOUN
gs-1912	56	7	were	be	AUX
gs-1912	56	8	analyzed	analyze	VERB
gs-1912	56	9	as	as	SCONJ
gs-1912	56	10	described	describe	VERB
gs-1912	56	11	below	below	ADV
gs-1912	56	12	.	.	PUNCT
gs-1912	57	1	after	after	ADP
gs-1912	57	2	completion	completion	NOUN
gs-1912	57	3	of	of	ADP
gs-1912	57	4	the	the	DET
gs-1912	57	5	permeation	permeation	NOUN
gs-1912	57	6	studies	study	NOUN
gs-1912	57	7	,	,	PUNCT
gs-1912	57	8	transport	transport	NOUN
gs-1912	57	9	medium	medium	NOUN
gs-1912	57	10	was	be	AUX
gs-1912	57	11	removed	remove	VERB
gs-1912	57	12	carefully	carefully	ADV
gs-1912	57	13	and	and	CCONJ
gs-1912	57	14	caco2	caco2	NOUN
gs-1912	57	15	cell	cell	NOUN
gs-1912	57	16	monolayers	monolayer	NOUN
gs-1912	57	17	were	be	AUX
gs-1912	57	18	rinsed	rinse	VERB
gs-1912	57	19	with	with	ADP
gs-1912	57	20	phosphate	phosphate	ADJ
gs-1912	57	21	buffer	buffer	NOUN
gs-1912	57	22	saline	saline	NOUN
gs-1912	57	23	(	(	PUNCT
gs-1912	57	24	ph	ph	NOUN
gs-1912	57	25	6.8	6.8	NUM
gs-1912	57	26	)	)	PUNCT
gs-1912	57	27	and	and	CCONJ
gs-1912	57	28	the	the	DET
gs-1912	57	29	culture	culture	NOUN
gs-1912	57	30	medium	medium	NOUN
gs-1912	57	31	was	be	AUX
gs-1912	57	32	applied	apply	VERB
gs-1912	57	33	on	on	ADP
gs-1912	57	34	the	the	DET
gs-1912	57	35	monolayers	monolayer	NOUN
gs-1912	57	36	.	.	PUNCT
gs-1912	58	1	the	the	DET
gs-1912	58	2	caco-2	caco-2	NUM
gs-1912	58	3	cell	cell	NOUN
gs-1912	58	4	monolayers	monolayer	NOUN
gs-1912	58	5	were	be	AUX
gs-1912	58	6	allowed	allow	VERB
gs-1912	58	7	to	to	PART
gs-1912	58	8	regenerate	regenerate	VERB
gs-1912	58	9	for	for	ADP
gs-1912	58	10	24	24	NUM
gs-1912	58	11	h	h	NOUN
gs-1912	58	12	in	in	ADP
gs-1912	58	13	the	the	DET
gs-1912	58	14	co₂-incubator	co₂-incubator	NOUN
gs-1912	58	15	.	.	PUNCT
gs-1912	59	1	chromatographic	chromatographic	ADJ
gs-1912	59	2	conditions	condition	NOUN
gs-1912	59	3	.	.	PUNCT
gs-1912	60	1	the	the	DET
gs-1912	60	2	quantitative	quantitative	ADJ
gs-1912	60	3	analysis	analysis	NOUN
gs-1912	60	4	of	of	ADP
gs-1912	60	5	samples	sample	NOUN
gs-1912	60	6	that	that	PRON
gs-1912	60	7	permeated	permeate	VERB
gs-1912	60	8	through	through	ADP
gs-1912	60	9	the	the	DET
gs-1912	60	10	monolayers	monolayer	NOUN
gs-1912	60	11	was	be	AUX
gs-1912	60	12	measured	measure	VERB
gs-1912	60	13	by	by	ADP
gs-1912	60	14	reversed	reverse	VERB
gs-1912	60	15	-	-	PUNCT
gs-1912	60	16	phase	phase	NOUN
gs-1912	60	17	hplc	hplc	NOUN
gs-1912	60	18	(	(	PUNCT
gs-1912	60	19	merck	merck	PROPN
gs-1912	60	20	hitachi	hitachi	PROPN
gs-1912	60	21	elite	elite	PROPN
gs-1912	60	22	lachrom	lachrom	PROPN
gs-1912	60	23	,	,	PUNCT
gs-1912	60	24	autosampler	autosampler	PROPN
gs-1912	60	25	l-2200	l-2200	PROPN
gs-1912	60	26	,	,	PUNCT
gs-1912	60	27	pump	pump	ADJ
gs-1912	60	28	l-2130	l-2130	PROPN
gs-1912	60	29	)	)	PUNCT
gs-1912	60	30	.	.	PUNCT
gs-1912	61	1	to	to	PART
gs-1912	61	2	determine	determine	VERB
gs-1912	61	3	the	the	DET
gs-1912	61	4	corresponding	correspond	VERB
gs-1912	61	5	alkaloids	alkaloid	NOUN
gs-1912	61	6	,	,	PUNCT
gs-1912	61	7	the	the	DET
gs-1912	61	8	samples	sample	NOUN
gs-1912	61	9	were	be	AUX
gs-1912	61	10	centrifuged	centrifuge	VERB
gs-1912	61	11	at	at	ADP
gs-1912	61	12	15000	15000	NUM
gs-1912	61	13	g	g	NOUN
gs-1912	61	14	for	for	ADP
gs-1912	61	15	5	5	NUM
gs-1912	61	16	min	min	NOUN
gs-1912	61	17	at	at	ADP
gs-1912	61	18	room	room	NOUN
gs-1912	61	19	temperature	temperature	NOUN
gs-1912	61	20	and	and	CCONJ
gs-1912	61	21	50	50	NUM
gs-1912	61	22	µl	µl	NOUN
gs-1912	61	23	of	of	ADP
gs-1912	61	24	supernatant	supernatant	NOUN
gs-1912	61	25	was	be	AUX
gs-1912	61	26	subjected	subject	VERB
gs-1912	61	27	to	to	ADP
gs-1912	61	28	hplc	hplc	NOUN
gs-1912	61	29	.	.	PUNCT
gs-1912	62	1	the	the	DET
gs-1912	62	2	amount	amount	NOUN
gs-1912	62	3	of	of	ADP
gs-1912	62	4	permeated	permeate	VERB
gs-1912	62	5	vinca	vinca	NOUN
gs-1912	62	6	alkaloids	alkaloid	NOUN
gs-1912	62	7	were	be	AUX
gs-1912	62	8	measured	measure	VERB
gs-1912	62	9	by	by	ADP
gs-1912	62	10	hplc	hplc	NOUN
gs-1912	62	11	in	in	ADP
gs-1912	62	12	accordance	accordance	NOUN
gs-1912	62	13	with	with	ADP
gs-1912	62	14	the	the	DET
gs-1912	62	15	previously	previously	ADV
gs-1912	62	16	reported	report	VERB
gs-1912	62	17	analytical	analytical	ADJ
gs-1912	62	18	method	method	NOUN
gs-1912	62	19	(	(	PUNCT
gs-1912	62	20	15	15	NUM
gs-1912	62	21	)	)	PUNCT
gs-1912	62	22	.	.	PUNCT
gs-1912	63	1	the	the	DET
gs-1912	63	2	column	column	NOUN
gs-1912	63	3	used	use	VERB
gs-1912	63	4	was	be	AUX
gs-1912	63	5	an	an	DET
gs-1912	63	6	agilent	agilent	PROPN
gs-1912	63	7	zorbax	zorbax	PROPN
gs-1912	63	8	eclipse	eclipse	NOUN
gs-1912	63	9	xdb	xdb	ADJ
gs-1912	63	10	-	-	PUNCT
gs-1912	63	11	c8	c8	PROPN
gs-1912	63	12	reversed	reverse	VERB
gs-1912	63	13	-	-	PUNCT
gs-1912	63	14	phase	phase	NOUN
gs-1912	63	15	column	column	NOUN
gs-1912	63	16	(	(	PUNCT
gs-1912	63	17	150	150	NUM
gs-1912	63	18	x	x	SYM
gs-1912	63	19	4.6	4.6	NUM
gs-1912	63	20	mm	mm	INTJ
gs-1912	63	21	i.d	i.d	PROPN
gs-1912	63	22	.	.	PROPN
gs-1912	63	23	;	;	PUNCT
gs-1912	63	24	5	5	NUM
gs-1912	63	25	µm	µm	NOUN
gs-1912	63	26	)	)	PUNCT
gs-1912	63	27	operated	operate	VERB
gs-1912	63	28	at	at	ADP
gs-1912	63	29	25	25	NUM
gs-1912	63	30	°	°	NOUN
gs-1912	63	31	c	c	NOUN
gs-1912	63	32	and	and	CCONJ
gs-1912	63	33	eluted	elute	VERB
gs-1912	63	34	with	with	ADP
gs-1912	63	35	0.1	0.1	NUM
gs-1912	63	36	%	%	NOUN
gs-1912	63	37	triethylamine	triethylamine	NOUN
gs-1912	63	38	(	(	PUNCT
gs-1912	63	39	solvent	solvent	NOUN
gs-1912	63	40	a	a	NOUN
gs-1912	63	41	)	)	PUNCT
gs-1912	63	42	and	and	CCONJ
gs-1912	63	43	methanol	methanol	NOUN
gs-1912	63	44	(	(	PUNCT
gs-1912	63	45	solvent	solvent	NOUN
gs-1912	63	46	b	b	NOUN
gs-1912	63	47	)	)	PUNCT
gs-1912	63	48	according	accord	VERB
gs-1912	63	49	to	to	ADP
gs-1912	63	50	the	the	DET
gs-1912	63	51	following	following	ADJ
gs-1912	63	52	protocol	protocol	NOUN
gs-1912	63	53	:	:	PUNCT
gs-1912	63	54	0–40	0–40	PROPN
gs-1912	63	55	min	min	PROPN
gs-1912	63	56	,	,	PUNCT
gs-1912	63	57	linear	linear	ADJ
gs-1912	63	58	gradient	gradient	NOUN
gs-1912	63	59	from	from	ADP
gs-1912	63	60	50:50	50:50	NUM
gs-1912	63	61	(	(	PUNCT
gs-1912	63	62	a	a	DET
gs-1912	63	63	:	:	SYM
gs-1912	63	64	b	b	NOUN
gs-1912	63	65	)	)	PUNCT
gs-1912	63	66	to	to	ADP
gs-1912	63	67	30:70	30:70	NUM
gs-1912	63	68	;	;	PUNCT
gs-1912	63	69	40–50	40–50	NUM
gs-1912	63	70	min	min	NOUN
gs-1912	63	71	,	,	PUNCT
gs-1912	63	72	isocratic	isocratic	ADJ
gs-1912	63	73	elution	elution	NOUN
gs-1912	63	74	with	with	ADP
gs-1912	63	75	10:90	10:90	NUM
gs-1912	63	76	;	;	PUNCT
gs-1912	63	77	and	and	CCONJ
gs-1912	63	78	50–60	50–60	NUM
gs-1912	63	79	min	min	NOUN
gs-1912	63	80	,	,	PUNCT
gs-1912	63	81	isocratic	isocratic	ADJ
gs-1912	63	82	elution	elution	NOUN
gs-1912	63	83	with	with	ADP
gs-1912	63	84	50:50	50:50	NUM
gs-1912	63	85	for	for	ADP
gs-1912	63	86	column	column	NOUN
gs-1912	63	87	equilibration	equilibration	NOUN
gs-1912	63	88	.	.	PUNCT
gs-1912	64	1	the	the	DET
gs-1912	64	2	flow	flow	NOUN
gs-1912	64	3	rate	rate	NOUN
gs-1912	64	4	was	be	AUX
gs-1912	64	5	0.8	0.8	NUM
gs-1912	64	6	ml	ml	NOUN
gs-1912	64	7	/	/	SYM
gs-1912	64	8	min	min	NOUN
gs-1912	64	9	and	and	CCONJ
gs-1912	64	10	absorbance	absorbance	NOUN
gs-1912	64	11	of	of	ADP
gs-1912	64	12	the	the	DET
gs-1912	64	13	alkaloids	alkaloid	NOUN
gs-1912	64	14	was	be	AUX
gs-1912	64	15	detected	detect	VERB
gs-1912	64	16	at	at	ADP
gs-1912	64	17	280	280	NUM
gs-1912	64	18	nm	nm	NOUN
gs-1912	64	19	.	.	PUNCT
gs-1912	65	1	no	no	DET
gs-1912	65	2	interference	interference	NOUN
gs-1912	65	3	from	from	ADP
gs-1912	65	4	any	any	DET
gs-1912	65	5	caco-2	caco-2	NUM
gs-1912	65	6	monolayers	monolayer	NOUN
gs-1912	65	7	substances	substance	NOUN
gs-1912	65	8	was	be	AUX
gs-1912	65	9	observed	observe	VERB
gs-1912	65	10	during	during	ADP
gs-1912	65	11	the	the	DET
gs-1912	65	12	elution	elution	NOUN
gs-1912	65	13	.	.	PUNCT
gs-1912	66	1	compounds	compound	NOUN
gs-1912	66	2	were	be	AUX
gs-1912	66	3	identified	identify	VERB
gs-1912	66	4	according	accord	VERB
gs-1912	66	5	to	to	ADP
gs-1912	66	6	peak	peak	NOUN
gs-1912	66	7	retention	retention	NOUN
gs-1912	66	8	times	time	NOUN
gs-1912	66	9	and	and	CCONJ
gs-1912	66	10	ms	ms	PROPN
gs-1912	66	11	(	(	PUNCT
gs-1912	66	12	fig	fig	NOUN
gs-1912	66	13	.	.	PUNCT
gs-1912	67	1	2	2	NUM
gs-1912	67	2	)	)	PUNCT
gs-1912	67	3	(	(	PUNCT
gs-1912	67	4	18	18	NUM
gs-1912	67	5	)	)	PUNCT
gs-1912	67	6	.	.	PUNCT
gs-1912	68	1	fig	fig	NOUN
gs-1912	68	2	2	2	NUM
gs-1912	68	3	.	.	PUNCT
gs-1912	68	4	retantion	retantion	NOUN
gs-1912	68	5	time	time	NOUN
gs-1912	68	6	and	and	CCONJ
gs-1912	68	7	identification	identification	NOUN
gs-1912	68	8	of	of	ADP
gs-1912	68	9	vingerbine	vingerbine	NOUN
gs-1912	68	10	alkaloids	alkaloid	NOUN
gs-1912	68	11	:	:	PUNCT
gs-1912	68	12	herbadine	herbadine	ADJ
gs-1912	68	13	(	(	PUNCT
gs-1912	68	14	1	1	NUM
gs-1912	68	15	)	)	PUNCT
gs-1912	68	16	,	,	PUNCT
gs-1912	68	17	herbamine	herbamine	ADJ
gs-1912	68	18	(	(	PUNCT
gs-1912	68	19	2	2	NUM
gs-1912	68	20	)	)	PUNCT
gs-1912	68	21	,	,	PUNCT
gs-1912	68	22	vincamajine	vincamajine	NOUN
gs-1912	68	23	(	(	PUNCT
gs-1912	68	24	3	3	NUM
gs-1912	68	25	)	)	PUNCT
gs-1912	68	26	,	,	PUNCT
gs-1912	68	27	vincarine	vincarine	VERB
gs-1912	68	28	(	(	PUNCT
gs-1912	68	29	4	4	NUM
gs-1912	68	30	)	)	PUNCT
gs-1912	68	31	data	datum	NOUN
gs-1912	68	32	analysis	analysis	NOUN
gs-1912	68	33	.	.	PUNCT
gs-1912	69	1	the	the	DET
gs-1912	69	2	permeability	permeability	NOUN
gs-1912	69	3	coefficient	coefficient	NOUN
gs-1912	69	4	was	be	AUX
gs-1912	69	5	calculated	calculate	VERB
gs-1912	69	6	from	from	ADP
gs-1912	69	7	:	:	PUNCT
gs-1912	69	8	dq	dq	NUM
gs-1912	69	9	1	1	NUM
gs-1912	69	10	papp=	papp=	NUM
gs-1912	69	11	georgian	georgian	PROPN
gs-1912	69	12	scientists/ქართველი	scientists/ქართველი	NOUN
gs-1912	69	13	მეცნიერები	მეცნიერები	NOUN
gs-1912	69	14	ტ.	ტ.	VERB
gs-1912	69	15	5	5	NUM
gs-1912	69	16	n	n	DET
gs-1912	69	17	2	2	NUM
gs-1912	69	18	,	,	PUNCT
gs-1912	69	19	2023	2023	NUM
gs-1912	69	20	224	224	NUM
gs-1912	69	21	where	where	SCONJ
gs-1912	69	22	dq	dq	NOUN
gs-1912	69	23	/	/	SYM
gs-1912	69	24	dt	dt	PROPN
gs-1912	69	25	is	be	AUX
gs-1912	69	26	the	the	DET
gs-1912	69	27	permeability	permeability	NOUN
gs-1912	69	28	rate	rate	NOUN
gs-1912	69	29	(	(	PUNCT
gs-1912	69	30	µg	µg	NOUN
gs-1912	69	31	/	/	SYM
gs-1912	69	32	s	s	NOUN
gs-1912	69	33	)	)	PUNCT
gs-1912	69	34	,	,	PUNCT
gs-1912	69	35	c₀	c₀	PROPN
gs-1912	69	36	is	be	AUX
gs-1912	69	37	the	the	DET
gs-1912	69	38	initial	initial	ADJ
gs-1912	69	39	concentration	concentration	NOUN
gs-1912	69	40	in	in	ADP
gs-1912	69	41	the	the	DET
gs-1912	69	42	donor	donor	NOUN
gs-1912	69	43	chamber	chamber	PROPN
gs-1912	69	44	(	(	PUNCT
gs-1912	69	45	µg	µg	ADV
gs-1912	69	46	/ml	/ml	ADJ
gs-1912	69	47	)	)	PUNCT
gs-1912	69	48	,	,	PUNCT
gs-1912	69	49	and	and	CCONJ
gs-1912	69	50	a	a	PRON
gs-1912	69	51	is	be	AUX
gs-1912	69	52	the	the	DET
gs-1912	69	53	membrane	membrane	NOUN
gs-1912	69	54	surface	surface	NOUN
gs-1912	69	55	area	area	NOUN
gs-1912	69	56	(	(	PUNCT
gs-1912	69	57	cm²	cm²	PROPN
gs-1912	69	58	)	)	PUNCT
gs-1912	69	59	.	.	PUNCT
gs-1912	70	1	efflux	efflux	NOUN
gs-1912	70	2	ratios	ratio	NOUN
gs-1912	70	3	(	(	PUNCT
gs-1912	70	4	pratio	pratio	NOUN
gs-1912	70	5	)	)	PUNCT
gs-1912	70	6	were	be	AUX
gs-1912	70	7	calculated	calculate	VERB
gs-1912	70	8	from	from	ADP
gs-1912	70	9	papp	papp	NOUN
gs-1912	70	10	values	value	NOUN
gs-1912	70	11	by	by	ADP
gs-1912	70	12	pefflux	pefflux	NOUN
gs-1912	70	13	=	=	SYM
gs-1912	70	14	secretory	secretory	ADJ
gs-1912	70	15	papp	papp	NOUN
gs-1912	70	16	/	/	SYM
gs-1912	70	17	absorptive	absorptive	ADJ
gs-1912	70	18	papp	papp	NOUN
gs-1912	70	19	.	.	PUNCT
gs-1912	71	1	percent	percent	NOUN
gs-1912	71	2	transport	transport	NOUN
gs-1912	71	3	(	(	PUNCT
gs-1912	71	4	%	%	INTJ
gs-1912	71	5	t	t	X
gs-1912	71	6	)	)	PUNCT
gs-1912	71	7	was	be	AUX
gs-1912	71	8	calculated	calculate	VERB
gs-1912	71	9	as	as	ADP
gs-1912	71	10	the	the	DET
gs-1912	71	11	ratio	ratio	NOUN
gs-1912	71	12	of	of	ADP
gs-1912	71	13	permeated	permeate	VERB
gs-1912	71	14	alkaloids	alkaloid	NOUN
gs-1912	71	15	in	in	ADP
gs-1912	71	16	the	the	DET
gs-1912	71	17	receiver	receiver	ADJ
gs-1912	71	18	side	side	NOUN
gs-1912	71	19	to	to	ADP
gs-1912	71	20	the	the	DET
gs-1912	71	21	initial	initial	ADJ
gs-1912	71	22	concentration	concentration	NOUN
gs-1912	71	23	in	in	ADP
gs-1912	71	24	the	the	DET
gs-1912	71	25	donor	donor	NOUN
gs-1912	71	26	side	side	NOUN
gs-1912	71	27	x100	x100	PROPN
gs-1912	71	28	.	.	PUNCT
gs-1912	72	1	transport	transport	NOUN
gs-1912	72	2	was	be	AUX
gs-1912	72	3	monitored	monitor	VERB
gs-1912	72	4	for	for	ADP
gs-1912	72	5	a	a	DET
gs-1912	72	6	period	period	NOUN
gs-1912	72	7	of	of	ADP
gs-1912	72	8	3	3	NUM
gs-1912	72	9	h.	h.	NOUN
gs-1912	72	10	statistical	statistical	ADJ
gs-1912	72	11	analysis	analysis	NOUN
gs-1912	72	12	.	.	PUNCT
gs-1912	73	1	all	all	DET
gs-1912	73	2	the	the	DET
gs-1912	73	3	experiments	experiment	NOUN
gs-1912	73	4	were	be	AUX
gs-1912	73	5	conducted	conduct	VERB
gs-1912	73	6	in	in	ADP
gs-1912	73	7	triplicate	triplicate	NOUN
gs-1912	73	8	and	and	CCONJ
gs-1912	73	9	the	the	DET
gs-1912	73	10	data	datum	NOUN
gs-1912	73	11	are	be	AUX
gs-1912	73	12	expressed	express	VERB
gs-1912	73	13	as	as	ADP
gs-1912	73	14	mean	mean	PROPN
gs-1912	73	15	±	±	NUM
gs-1912	73	16	sem	sem	NOUN
gs-1912	73	17	.	.	PUNCT
gs-1912	74	1	the	the	DET
gs-1912	74	2	statistical	statistical	ADJ
gs-1912	74	3	significance	significance	NOUN
gs-1912	74	4	of	of	ADP
gs-1912	74	5	difference	difference	NOUN
gs-1912	74	6	was	be	AUX
gs-1912	74	7	analyzed	analyze	VERB
gs-1912	74	8	using	use	VERB
gs-1912	74	9	student	student	NOUN
gs-1912	74	10	’s	’s	PART
gs-1912	74	11	t	t	PROPN
gs-1912	74	12	-	-	PUNCT
gs-1912	74	13	test	test	NOUN
gs-1912	74	14	.	.	PUNCT
gs-1912	75	1	values	value	NOUN
gs-1912	75	2	of	of	ADP
gs-1912	75	3	p	p	NOUN
gs-1912	75	4	<	<	X
gs-1912	75	5	0.05	0.05	NUM
gs-1912	75	6	were	be	AUX
gs-1912	75	7	considered	consider	VERB
gs-1912	75	8	results	result	NOUN
gs-1912	75	9	and	and	CCONJ
gs-1912	75	10	discussion	discussion	NOUN
gs-1912	75	11	the	the	DET
gs-1912	75	12	present	present	ADJ
gs-1912	75	13	study	study	NOUN
gs-1912	75	14	was	be	AUX
gs-1912	75	15	undertaken	undertake	VERB
gs-1912	75	16	to	to	PART
gs-1912	75	17	determine	determine	VERB
gs-1912	75	18	the	the	DET
gs-1912	75	19	bioavailability	bioavailability	NOUN
gs-1912	75	20	and	and	CCONJ
gs-1912	75	21	intestinal	intestinal	ADJ
gs-1912	75	22	transport	transport	NOUN
gs-1912	75	23	of	of	ADP
gs-1912	75	24	the	the	DET
gs-1912	75	25	vingerbine	vingerbine	NOUN
gs-1912	75	26	compounding	compound	VERB
gs-1912	75	27	vinca	vinca	NOUN
gs-1912	75	28	alkaloids	alkaloid	NOUN
gs-1912	75	29	:	:	PUNCT
gs-1912	75	30	vincarine	vincarine	ADJ
gs-1912	75	31	,	,	PUNCT
gs-1912	75	32	herbadine	herbadine	ADJ
gs-1912	75	33	,	,	PUNCT
gs-1912	75	34	vincamajine	vincamajine	ADJ
gs-1912	75	35	and	and	CCONJ
gs-1912	75	36	herbamine	herbamine	ADJ
gs-1912	75	37	(	(	PUNCT
gs-1912	75	38	fig	fig	NOUN
gs-1912	75	39	.	.	NOUN
gs-1912	76	1	1	1	NUM
gs-1912	76	2	)	)	PUNCT
gs-1912	76	3	using	use	VERB
gs-1912	76	4	caco-2	caco-2	NUM
gs-1912	76	5	cell	cell	NOUN
gs-1912	76	6	monolayer	monolayer	NOUN
gs-1912	76	7	.	.	PUNCT
gs-1912	77	1	the	the	DET
gs-1912	77	2	two	two	NUM
gs-1912	77	3	transport	transport	NOUN
gs-1912	77	4	parameters	parameter	NOUN
gs-1912	77	5	,	,	PUNCT
gs-1912	77	6	permeability	permeability	NOUN
gs-1912	77	7	coefficient	coefficient	NOUN
gs-1912	77	8	(	(	PUNCT
gs-1912	77	9	papp	papp	NOUN
gs-1912	77	10	)	)	PUNCT
gs-1912	77	11	and	and	CCONJ
gs-1912	77	12	percent	percent	NOUN
gs-1912	77	13	transport	transport	NOUN
gs-1912	77	14	(	(	PUNCT
gs-1912	77	15	%	%	INTJ
gs-1912	77	16	t	t	PROPN
gs-1912	77	17	)	)	PUNCT
gs-1912	77	18	for	for	ADP
gs-1912	77	19	these	these	DET
gs-1912	77	20	compounds	compound	NOUN
gs-1912	77	21	were	be	AUX
gs-1912	77	22	determined	determine	VERB
gs-1912	77	23	in	in	ADP
gs-1912	77	24	the	the	DET
gs-1912	77	25	apical	apical	ADJ
gs-1912	77	26	to	to	ADP
gs-1912	77	27	basolateral	basolateral	ADJ
gs-1912	77	28	(	(	PUNCT
gs-1912	77	29	absorptive	absorptive	ADJ
gs-1912	77	30	)	)	PUNCT
gs-1912	77	31	,	,	PUNCT
gs-1912	77	32	as	as	ADV
gs-1912	77	33	well	well	ADV
gs-1912	77	34	as	as	ADP
gs-1912	77	35	in	in	ADP
gs-1912	77	36	the	the	DET
gs-1912	77	37	basolateral	basolateral	NOUN
gs-1912	77	38	to	to	ADP
gs-1912	77	39	apical	apical	ADJ
gs-1912	77	40	(	(	PUNCT
gs-1912	77	41	secretive	secretive	ADJ
gs-1912	77	42	)	)	PUNCT
gs-1912	77	43	direction	direction	NOUN
gs-1912	77	44	of	of	ADP
gs-1912	77	45	the	the	DET
gs-1912	77	46	monolayer	monolayer	NOUN
gs-1912	77	47	.	.	PUNCT
gs-1912	78	1	transport	transport	NOUN
gs-1912	78	2	was	be	AUX
gs-1912	78	3	monitored	monitor	VERB
gs-1912	78	4	for	for	ADP
gs-1912	78	5	a	a	DET
gs-1912	78	6	period	period	NOUN
gs-1912	78	7	of	of	ADP
gs-1912	78	8	3	3	NUM
gs-1912	78	9	h.	h.	NOUN
gs-1912	78	10	the	the	DET
gs-1912	78	11	cumulative	cumulative	ADJ
gs-1912	78	12	amount	amount	NOUN
gs-1912	78	13	transported	transport	VERB
gs-1912	78	14	with	with	ADP
gs-1912	78	15	respect	respect	NOUN
gs-1912	78	16	to	to	ADP
gs-1912	78	17	time	time	NOUN
gs-1912	78	18	is	be	AUX
gs-1912	78	19	shown	show	VERB
gs-1912	78	20	in	in	ADP
gs-1912	78	21	fig	fig	NOUN
gs-1912	78	22	.	.	PUNCT
gs-1912	79	1	3	3	NUM
gs-1912	79	2	;	;	PUNCT
gs-1912	79	3	the	the	DET
gs-1912	79	4	percent	percent	NOUN
gs-1912	79	5	of	of	ADP
gs-1912	79	6	transported	transport	VERB
gs-1912	79	7	compounds	compound	NOUN
gs-1912	79	8	and	and	CCONJ
gs-1912	79	9	compared	compare	VERB
gs-1912	79	10	degree	degree	NOUN
gs-1912	79	11	of	of	ADP
gs-1912	79	12	ap	ap	PROPN
gs-1912	79	13	-	-	PUNCT
gs-1912	79	14	to	to	ADP
gs-1912	79	15	-	-	PUNCT
gs-1912	79	16	bl	bl	NOUN
gs-1912	79	17	and	and	CCONJ
gs-1912	79	18	bl	bl	PROPN
gs-1912	79	19	-	-	PUNCT
gs-1912	79	20	to	to	ADP
gs-1912	79	21	-	-	PUNCT
gs-1912	79	22	ap	ap	NOUN
gs-1912	79	23	fluxes	flux	NOUN
gs-1912	79	24	are	be	AUX
gs-1912	79	25	listed	list	VERB
gs-1912	79	26	in	in	ADP
gs-1912	79	27	table	table	NOUN
gs-1912	79	28	.	.	PUNCT
gs-1912	80	1	fig	fig	NOUN
gs-1912	80	2	.	.	PUNCT
gs-1912	81	1	3	3	X
gs-1912	81	2	.	.	NOUN
gs-1912	81	3	transepithelial	transepithelial	ADJ
gs-1912	81	4	transport	transport	NOUN
gs-1912	81	5	across	across	ADP
gs-1912	81	6	caco-2	caco-2	NUM
gs-1912	81	7	cells	cell	NOUN
gs-1912	81	8	of	of	ADP
gs-1912	81	9	vincarine	vincarine	NOUN
gs-1912	81	10	(	(	PUNCT
gs-1912	81	11	a	a	NOUN
gs-1912	81	12	)	)	PUNCT
gs-1912	81	13	and	and	CCONJ
gs-1912	81	14	herbadine	herbadine	ADJ
gs-1912	81	15	(	(	PUNCT
gs-1912	81	16	b	b	NOUN
gs-1912	81	17	)	)	PUNCT
gs-1912	81	18	.	.	PUNCT
gs-1912	82	1	each	each	DET
gs-1912	82	2	value	value	NOUN
gs-1912	82	3	represents	represent	VERB
gs-1912	82	4	the	the	DET
gs-1912	82	5	mean	mean	ADJ
gs-1912	82	6	±	±	NUM
gs-1912	82	7	sd	sd	NOUN
gs-1912	82	8	of	of	ADP
gs-1912	82	9	at	at	ADV
gs-1912	82	10	least	least	ADV
gs-1912	82	11	3	3	NUM
gs-1912	82	12	trials	trial	NOUN
gs-1912	82	13	.	.	PUNCT
gs-1912	83	1	a	a	DET
gs-1912	83	2	0	0	NUM
gs-1912	83	3	5	5	NUM
gs-1912	83	4	10	10	NUM
gs-1912	83	5	15	15	NUM
gs-1912	83	6	20	20	NUM
gs-1912	83	7	25	25	NUM
gs-1912	83	8	0	0	NUM
gs-1912	83	9	1	1	NUM
gs-1912	83	10	2	2	NUM
gs-1912	83	11	3time	3time	NUM
gs-1912	83	12	,	,	PUNCT
gs-1912	83	13	h	h	NOUN
gs-1912	83	14	a	a	DET
gs-1912	83	15	lk	lk	NOUN
gs-1912	83	16	a	a	DET
gs-1912	83	17	lo	lo	NOUN
gs-1912	84	1	i	i	PROPN
gs-1912	84	2	d	d	PROPN
gs-1912	84	3	t	t	PROPN
gs-1912	84	4	ra	ra	PROPN
gs-1912	85	1	n	n	PROPN
gs-1912	85	2	s	s	PROPN
gs-1912	85	3	p	p	NOUN
gs-1912	85	4	o	o	X
gs-1912	85	5	rt	rt	PROPN
gs-1912	86	1	(	(	PUNCT
gs-1912	86	2	%	%	INTJ
gs-1912	86	3	o	o	X
gs-1912	87	1	f	f	X
gs-1912	88	1	d	d	X
gs-1912	88	2	o	o	X
gs-1912	88	3	n	n	X
gs-1912	88	4	o	o	NOUN
gs-1912	88	5	r	r	NOUN
gs-1912	88	6	)	)	PUNCT
gs-1912	89	1	ab	ab	PROPN
gs-1912	89	2	ba	ba	PROPN
gs-1912	89	3	b	b	PROPN
gs-1912	89	4	0	0	NUM
gs-1912	89	5	5	5	NUM
gs-1912	89	6	10	10	NUM
gs-1912	89	7	15	15	NUM
gs-1912	89	8	20	20	NUM
gs-1912	89	9	25	25	NUM
gs-1912	89	10	0	0	NUM
gs-1912	89	11	1	1	NUM
gs-1912	89	12	2	2	NUM
gs-1912	89	13	3	3	NUM
gs-1912	89	14	time	time	NOUN
gs-1912	89	15	,	,	PUNCT
gs-1912	89	16	h	h	NOUN
gs-1912	89	17	a	a	DET
gs-1912	89	18	lk	lk	NOUN
gs-1912	89	19	a	a	DET
gs-1912	89	20	lo	lo	NOUN
gs-1912	90	1	i	i	PROPN
gs-1912	90	2	d	d	PROPN
gs-1912	90	3	t	t	PROPN
gs-1912	90	4	ra	ra	PROPN
gs-1912	91	1	n	n	PROPN
gs-1912	91	2	s	s	PROPN
gs-1912	91	3	p	p	NOUN
gs-1912	91	4	o	o	X
gs-1912	91	5	rt	rt	PROPN
gs-1912	92	1	(	(	PUNCT
gs-1912	92	2	%	%	INTJ
gs-1912	92	3	o	o	X
gs-1912	93	1	f	f	X
gs-1912	94	1	d	d	X
gs-1912	94	2	o	o	X
gs-1912	94	3	n	n	X
gs-1912	94	4	o	o	NOUN
gs-1912	94	5	r	r	NOUN
gs-1912	94	6	)	)	PUNCT
gs-1912	94	7	ab	ab	PROPN
gs-1912	94	8	ba	ba	PROPN
gs-1912	94	9	georgian	georgian	PROPN
gs-1912	94	10	scientists/ქართველი	scientists/ქართველი	PROPN
gs-1912	94	11	მეცნიერები	მეცნიერები	NOUN
gs-1912	94	12	ტ.	ტ.	VERB
gs-1912	94	13	5	5	NUM
gs-1912	94	14	n	n	PRON
gs-1912	94	15	2	2	NUM
gs-1912	94	16	,	,	PUNCT
gs-1912	94	17	2023	2023	NUM
gs-1912	94	18	225	225	NUM
gs-1912	94	19	table	table	NOUN
gs-1912	94	20	transport	transport	NOUN
gs-1912	94	21	of	of	ADP
gs-1912	94	22	vingerbine	vingerbine	NOUN
gs-1912	94	23	alkaloids	alkaloid	NOUN
gs-1912	94	24	across	across	ADP
gs-1912	94	25	caco-2	caco-2	NUM
gs-1912	94	26	monolayer	monolayer	NOUN
gs-1912	94	27	(	(	PUNCT
gs-1912	94	28	means	mean	VERB
gs-1912	94	29	±	±	NUM
gs-1912	94	30	sd	sd	NOUN
gs-1912	94	31	;	;	PUNCT
gs-1912	94	32	n	n	NOUN
gs-1912	94	33	=	=	SYM
gs-1912	94	34	3	3	NUM
gs-1912	94	35	-	-	SYM
gs-1912	94	36	5	5	NUM
gs-1912	94	37	)	)	PUNCT
gs-1912	94	38	compounds	compound	VERB
gs-1912	94	39	absorptive	absorptive	ADJ
gs-1912	94	40	(	(	PUNCT
gs-1912	94	41	ap	ap	NOUN
gs-1912	94	42	to	to	PART
gs-1912	94	43	bl	bl	VERB
gs-1912	94	44	)	)	PUNCT
gs-1912	94	45	secretory	secretory	NOUN
gs-1912	94	46	(	(	PUNCT
gs-1912	94	47	bl	bl	INTJ
gs-1912	94	48	to	to	PART
gs-1912	94	49	ap	ap	PROPN
gs-1912	94	50	)	)	PUNCT
gs-1912	94	51	pratio	pratio	NOUN
gs-1912	94	52	papp	papp	NOUN
gs-1912	94	53	(	(	PUNCT
gs-1912	94	54	cm	cm	NOUN
gs-1912	94	55	/	/	SYM
gs-1912	94	56	s	s	NOUN
gs-1912	94	57	)	)	PUNCT
gs-1912	94	58	x	x	SYM
gs-1912	94	59	10⁻⁵	10⁻⁵	NUM
gs-1912	94	60	%	%	NOUN
gs-1912	94	61	t	t	PROPN
gs-1912	94	62	papp	papp	NOUN
gs-1912	94	63	(	(	PUNCT
gs-1912	94	64	cm	cm	NOUN
gs-1912	94	65	/	/	SYM
gs-1912	94	66	s	s	NOUN
gs-1912	94	67	)	)	PUNCT
gs-1912	94	68	x	x	SYM
gs-1912	94	69	10⁻⁵	10⁻⁵	NUM
gs-1912	94	70	%	%	NOUN
gs-1912	94	71	t	t	PROPN
gs-1912	94	72	vincarine	vincarine	VERB
gs-1912	94	73	0.65	0.65	NUM
gs-1912	94	74	±	±	NUM
gs-1912	94	75	0.12	0.12	NUM
gs-1912	94	76	7.82	7.82	NUM
gs-1912	94	77	±	±	NUM
gs-1912	94	78	1.48	1.48	NUM
gs-1912	94	79	1.78	1.78	NUM
gs-1912	94	80	±	±	NUM
gs-1912	94	81	0.13	0.13	NUM
gs-1912	94	82	21.48	21.48	NUM
gs-1912	94	83	±	±	NUM
gs-1912	94	84	1.54	1.54	NUM
gs-1912	94	85	2.74	2.74	NUM
gs-1912	94	86	herbadine	herbadine	ADJ
gs-1912	94	87	0.73	0.73	NUM
gs-1912	94	88	±	±	NUM
gs-1912	94	89	0.12	0.12	NUM
gs-1912	94	90	8.85	8.85	NUM
gs-1912	94	91	±	±	NUM
gs-1912	94	92	1,50	1,50	NUM
gs-1912	94	93	1.64	1.64	NUM
gs-1912	94	94	±	±	NUM
gs-1912	94	95	0.04	0.04	NUM
gs-1912	94	96	19.83	19.83	NUM
gs-1912	94	97	±	±	NUM
gs-1912	94	98	0.49	0.49	NUM
gs-1912	94	99	2.27	2.27	NUM
gs-1912	94	100	as	as	SCONJ
gs-1912	94	101	illustrated	illustrate	VERB
gs-1912	94	102	in	in	ADP
gs-1912	94	103	fig	fig	NOUN
gs-1912	94	104	.	.	PUNCT
gs-1912	95	1	3	3	NUM
gs-1912	95	2	,	,	PUNCT
gs-1912	95	3	two	two	NUM
gs-1912	95	4	vingerbine	vingerbine	NOUN
gs-1912	95	5	alkaloids	alkaloid	NOUN
gs-1912	95	6	demonstrated	demonstrate	VERB
gs-1912	95	7	bidirectional	bidirectional	ADJ
gs-1912	95	8	transport	transport	NOUN
gs-1912	95	9	;	;	PUNCT
gs-1912	95	10	bl	bl	PROPN
gs-1912	95	11	-	-	PUNCT
gs-1912	95	12	toap	toap	PROPN
gs-1912	95	13	flux	flux	NOUN
gs-1912	95	14	for	for	ADP
gs-1912	95	15	vincarine	vincarine	VERB
gs-1912	95	16	and	and	CCONJ
gs-1912	95	17	herbadine	herbadine	ADJ
gs-1912	95	18	was	be	AUX
gs-1912	95	19	found	find	VERB
gs-1912	95	20	to	to	PART
gs-1912	95	21	be	be	AUX
gs-1912	95	22	significantly	significantly	ADV
gs-1912	95	23	higher	high	ADJ
gs-1912	95	24	than	than	ADP
gs-1912	95	25	ap	ap	VERB
gs-1912	95	26	-	-	PUNCT
gs-1912	95	27	to	to	ADP
gs-1912	95	28	-	-	PUNCT
gs-1912	95	29	bl	bl	VERB
gs-1912	95	30	;	;	PUNCT
gs-1912	95	31	the	the	DET
gs-1912	95	32	mean	mean	ADJ
gs-1912	95	33	apparent	apparent	ADJ
gs-1912	95	34	permeability	permeability	NOUN
gs-1912	95	35	coefficients	coefficient	NOUN
gs-1912	95	36	(	(	PUNCT
gs-1912	95	37	papp	papp	NOUN
gs-1912	95	38	)	)	PUNCT
gs-1912	95	39	of	of	ADP
gs-1912	95	40	vincarine	vincarine	VERB
gs-1912	95	41	and	and	CCONJ
gs-1912	95	42	herbadine	herbadine	VERB
gs-1912	95	43	in	in	ADP
gs-1912	95	44	the	the	DET
gs-1912	95	45	absorptive	absorptive	ADJ
gs-1912	95	46	direction	direction	NOUN
gs-1912	95	47	were	be	AUX
gs-1912	95	48	accordingly	accordingly	ADV
gs-1912	95	49	2.74	2.74	NUM
gs-1912	95	50	and	and	CCONJ
gs-1912	95	51	2.27fold	2.27fold	NUM
gs-1912	95	52	higher	high	ADJ
gs-1912	95	53	than	than	ADP
gs-1912	95	54	those	those	PRON
gs-1912	95	55	in	in	ADP
gs-1912	95	56	the	the	DET
gs-1912	95	57	secretory	secretory	ADJ
gs-1912	95	58	direction	direction	NOUN
gs-1912	95	59	(	(	PUNCT
gs-1912	95	60	table	table	NOUN
gs-1912	95	61	)	)	PUNCT
gs-1912	95	62	.	.	PUNCT
gs-1912	96	1	p	p	X
gs-1912	96	2	-	-	PUNCT
gs-1912	96	3	gp	gp	NOUN
gs-1912	96	4	efflux	efflux	NOUN
gs-1912	96	5	resulted	result	VERB
gs-1912	96	6	in	in	ADP
gs-1912	96	7	higher	high	ADJ
gs-1912	96	8	bl	bl	NOUN
gs-1912	96	9	to	to	PART
gs-1912	96	10	ap	ap	PROPN
gs-1912	96	11	transport	transport	PROPN
gs-1912	96	12	than	than	SCONJ
gs-1912	96	13	ap	ap	VERB
gs-1912	96	14	to	to	PART
gs-1912	96	15	bl	bl	VERB
gs-1912	96	16	transport	transport	NOUN
gs-1912	96	17	(	(	PUNCT
gs-1912	96	18	21	21	NUM
gs-1912	96	19	)	)	PUNCT
gs-1912	96	20	.	.	PUNCT
gs-1912	97	1	this	this	DET
gs-1912	97	2	assay	assay	NOUN
gs-1912	97	3	,	,	PUNCT
gs-1912	97	4	where	where	SCONJ
gs-1912	97	5	p	p	NOUN
gs-1912	97	6	ratio	ratio	NOUN
gs-1912	97	7	was	be	AUX
gs-1912	97	8	compared	compare	VERB
gs-1912	97	9	with	with	ADP
gs-1912	97	10	a	a	DET
gs-1912	97	11	value	value	NOUN
gs-1912	97	12	of	of	ADP
gs-1912	97	13	1	1	NUM
gs-1912	97	14	,	,	PUNCT
gs-1912	97	15	was	be	AUX
gs-1912	97	16	regarded	regard	VERB
gs-1912	97	17	as	as	ADP
gs-1912	97	18	the	the	DET
gs-1912	97	19	standard	standard	NOUN
gs-1912	97	20	for	for	ADP
gs-1912	97	21	identified	identify	VERB
gs-1912	97	22	p	p	NOUN
gs-1912	97	23	-	-	PUNCT
gs-1912	97	24	gp	gp	NOUN
gs-1912	97	25	substrates	substrate	NOUN
gs-1912	97	26	.	.	PUNCT
gs-1912	98	1	involvement	involvement	NOUN
gs-1912	98	2	of	of	ADP
gs-1912	98	3	a	a	DET
gs-1912	98	4	p	p	NOUN
gs-1912	98	5	-	-	PUNCT
gs-1912	98	6	gp	gp	NOUN
gs-1912	98	7	mediated	mediate	VERB
gs-1912	98	8	efflux	efflux	NOUN
gs-1912	98	9	mechanisms	mechanism	NOUN
gs-1912	98	10	was	be	AUX
gs-1912	98	11	indicated	indicate	VERB
gs-1912	98	12	if	if	SCONJ
gs-1912	98	13	the	the	DET
gs-1912	98	14	pratio	pratio	NOUN
gs-1912	98	15	>	>	X
gs-1912	98	16	2	2	X
gs-1912	98	17	.	.	PUNCT
gs-1912	99	1	the	the	DET
gs-1912	99	2	%	%	NOUN
gs-1912	99	3	t	t	NOUN
gs-1912	99	4	for	for	ADP
gs-1912	99	5	these	these	DET
gs-1912	99	6	alkaloids	alkaloid	NOUN
gs-1912	99	7	in	in	ADP
gs-1912	99	8	the	the	DET
gs-1912	99	9	mixture	mixture	NOUN
gs-1912	99	10	vary	vary	VERB
gs-1912	99	11	from	from	ADP
gs-1912	99	12	7.8	7.8	NUM
gs-1912	99	13	8.85	8.85	NUM
gs-1912	99	14	%	%	NOUN
gs-1912	99	15	for	for	ADP
gs-1912	99	16	absorptive	absorptive	ADJ
gs-1912	99	17	and	and	CCONJ
gs-1912	99	18	19.83	19.83	NUM
gs-1912	99	19	21.5	21.5	NUM
gs-1912	99	20	%	%	NOUN
gs-1912	99	21	for	for	ADP
gs-1912	99	22	secretory	secretory	ADJ
gs-1912	99	23	directions	direction	NOUN
gs-1912	99	24	.	.	PUNCT
gs-1912	100	1	the	the	DET
gs-1912	100	2	results	result	NOUN
gs-1912	100	3	suggest	suggest	VERB
gs-1912	100	4	that	that	SCONJ
gs-1912	100	5	specific	specific	ADJ
gs-1912	100	6	efflux	efflux	NOUN
gs-1912	100	7	systems	system	NOUN
gs-1912	100	8	such	such	ADJ
gs-1912	100	9	as	as	ADP
gs-1912	100	10	p	p	NOUN
gs-1912	100	11	-	-	PUNCT
gs-1912	100	12	gp	gp	NOUN
gs-1912	100	13	may	may	AUX
gs-1912	100	14	be	be	AUX
gs-1912	100	15	involved	involve	VERB
gs-1912	100	16	in	in	ADP
gs-1912	100	17	the	the	DET
gs-1912	100	18	permeation	permeation	NOUN
gs-1912	100	19	of	of	ADP
gs-1912	100	20	these	these	DET
gs-1912	100	21	alkaloids	alkaloid	NOUN
gs-1912	100	22	.	.	PUNCT
gs-1912	101	1	this	this	DET
gs-1912	101	2	directional	directional	ADJ
gs-1912	101	3	difference	difference	NOUN
gs-1912	101	4	in	in	ADP
gs-1912	101	5	transport	transport	NOUN
gs-1912	101	6	was	be	AUX
gs-1912	101	7	not	not	PART
gs-1912	101	8	observed	observe	VERB
gs-1912	101	9	with	with	ADP
gs-1912	101	10	vincamajine	vincamajine	ADJ
gs-1912	101	11	and	and	CCONJ
gs-1912	101	12	herbamine	herbamine	ADJ
gs-1912	101	13	;	;	PUNCT
gs-1912	101	14	for	for	ADP
gs-1912	101	15	them	they	PRON
gs-1912	101	16	fluxes	flux	NOUN
gs-1912	101	17	were	be	AUX
gs-1912	101	18	approximately	approximately	ADV
gs-1912	101	19	equal	equal	ADJ
gs-1912	101	20	in	in	ADP
gs-1912	101	21	both	both	DET
gs-1912	101	22	directions	direction	NOUN
gs-1912	101	23	.	.	PUNCT
gs-1912	102	1	after	after	ADP
gs-1912	102	2	one	one	NUM
gs-1912	102	3	hour	hour	NOUN
gs-1912	102	4	exposure	exposure	NOUN
gs-1912	102	5	,	,	PUNCT
gs-1912	102	6	the	the	DET
gs-1912	102	7	rapid	rapid	ADJ
gs-1912	102	8	raise	raise	NOUN
gs-1912	102	9	of	of	ADP
gs-1912	102	10	transport	transport	NOUN
gs-1912	102	11	was	be	AUX
gs-1912	102	12	observed	observe	VERB
gs-1912	102	13	in	in	ADP
gs-1912	102	14	both	both	DET
gs-1912	102	15	directions	direction	NOUN
gs-1912	102	16	.	.	PUNCT
gs-1912	103	1	this	this	PRON
gs-1912	103	2	pronounced	pronounce	VERB
gs-1912	103	3	rise	rise	NOUN
gs-1912	103	4	of	of	ADP
gs-1912	103	5	influx	influx	NOUN
gs-1912	103	6	and	and	CCONJ
gs-1912	103	7	efflux	efflux	NOUN
gs-1912	103	8	can	can	AUX
gs-1912	103	9	not	not	PART
gs-1912	103	10	be	be	AUX
gs-1912	103	11	attributed	attribute	VERB
gs-1912	103	12	to	to	ADP
gs-1912	103	13	drug	drug	NOUN
gs-1912	103	14	-	-	PUNCT
gs-1912	103	15	induced	induce	VERB
gs-1912	103	16	membrane	membrane	NOUN
gs-1912	103	17	damage	damage	NOUN
gs-1912	103	18	,	,	PUNCT
gs-1912	103	19	as	as	SCONJ
gs-1912	103	20	the	the	DET
gs-1912	103	21	used	use	VERB
gs-1912	103	22	concentrations	concentration	NOUN
gs-1912	103	23	of	of	ADP
gs-1912	103	24	alkaloids	alkaloid	NOUN
gs-1912	103	25	and	and	CCONJ
gs-1912	103	26	dmso	dmso	NOUN
gs-1912	103	27	do	do	AUX
gs-1912	103	28	not	not	PART
gs-1912	103	29	change	change	VERB
gs-1912	103	30	normal	normal	ADJ
gs-1912	103	31	mucosal	mucosal	NOUN
gs-1912	103	32	cell	cell	NOUN
gs-1912	103	33	morphology	morphology	NOUN
gs-1912	103	34	.	.	PUNCT
gs-1912	104	1	the	the	DET
gs-1912	104	2	efflux	efflux	NOUN
gs-1912	104	3	ratio	ratio	NOUN
gs-1912	104	4	value	value	NOUN
gs-1912	104	5	around	around	ADV
gs-1912	104	6	of	of	ADP
gs-1912	104	7	1	1	NUM
gs-1912	104	8	(	(	PUNCT
gs-1912	104	9	0.84	0.84	NUM
gs-1912	104	10	±	±	NUM
gs-1912	104	11	0.35	0.35	NUM
gs-1912	104	12	and	and	CCONJ
gs-1912	104	13	0.72	0.72	NUM
gs-1912	104	14	±	±	NUM
gs-1912	104	15	0.14	0.14	NUM
gs-1912	104	16	for	for	ADP
gs-1912	104	17	vincamajine	vincamajine	ADJ
gs-1912	104	18	and	and	CCONJ
gs-1912	104	19	herbamine	herbamine	ADJ
gs-1912	104	20	correspondingly	correspondingly	ADV
gs-1912	104	21	)	)	PUNCT
gs-1912	104	22	means	mean	VERB
gs-1912	104	23	that	that	SCONJ
gs-1912	104	24	the	the	DET
gs-1912	104	25	permeation	permeation	NOUN
gs-1912	104	26	of	of	ADP
gs-1912	104	27	these	these	DET
gs-1912	104	28	compounds	compound	NOUN
gs-1912	104	29	in	in	ADP
gs-1912	104	30	the	the	DET
gs-1912	104	31	ap	ap	PROPN
gs-1912	104	32	-	-	PUNCT
gs-1912	104	33	to	to	ADP
gs-1912	104	34	-	-	PUNCT
gs-1912	104	35	bl	bl	NOUN
gs-1912	104	36	and	and	CCONJ
gs-1912	104	37	bl	bl	PROPN
gs-1912	104	38	-	-	PUNCT
gs-1912	104	39	to	to	ADP
gs-1912	104	40	-	-	PUNCT
gs-1912	104	41	ap	ap	NOUN
gs-1912	104	42	directions	direction	NOUN
gs-1912	104	43	is	be	AUX
gs-1912	104	44	identical	identical	ADJ
gs-1912	104	45	,	,	PUNCT
gs-1912	104	46	and	and	CCONJ
gs-1912	104	47	is	be	AUX
gs-1912	104	48	consistent	consistent	ADJ
gs-1912	104	49	with	with	ADP
gs-1912	104	50	permeation	permeation	NOUN
gs-1912	104	51	by	by	ADP
gs-1912	104	52	simple	simple	ADJ
gs-1912	104	53	passive	passive	ADJ
gs-1912	104	54	diffusion	diffusion	NOUN
gs-1912	104	55	.	.	PUNCT
gs-1912	105	1	the	the	DET
gs-1912	105	2	functional	functional	ADJ
gs-1912	105	3	involvement	involvement	NOUN
gs-1912	105	4	of	of	ADP
gs-1912	105	5	p	p	NOUN
gs-1912	105	6	-	-	PUNCT
gs-1912	105	7	gp	gp	NOUN
gs-1912	105	8	in	in	ADP
gs-1912	105	9	this	this	DET
gs-1912	105	10	process	process	NOUN
gs-1912	105	11	was	be	AUX
gs-1912	105	12	verified	verify	VERB
gs-1912	105	13	by	by	ADP
gs-1912	105	14	the	the	DET
gs-1912	105	15	addition	addition	NOUN
gs-1912	105	16	of	of	ADP
gs-1912	105	17	verapamil	verapamil	NOUN
gs-1912	105	18	,	,	PUNCT
gs-1912	105	19	often	often	ADV
gs-1912	105	20	used	use	VERB
gs-1912	105	21	at	at	ADP
gs-1912	105	22	100	100	NUM
gs-1912	105	23	µm	µm	NOUN
gs-1912	105	24	to	to	PART
gs-1912	105	25	selectively	selectively	ADV
gs-1912	105	26	inhibit	inhibit	VERB
gs-1912	105	27	the	the	DET
gs-1912	105	28	p	p	NOUN
gs-1912	105	29	-	-	PUNCT
gs-1912	105	30	gp	gp	NOUN
gs-1912	105	31	-	-	PUNCT
gs-1912	105	32	based	base	VERB
gs-1912	105	33	efflux	efflux	NOUN
gs-1912	105	34	transport	transport	NOUN
gs-1912	105	35	.	.	PUNCT
gs-1912	106	1	studies	study	NOUN
gs-1912	106	2	have	have	AUX
gs-1912	106	3	suggested	suggest	VERB
gs-1912	106	4	that	that	SCONJ
gs-1912	106	5	verapamil	verapamil	NOUN
gs-1912	106	6	competes	compete	VERB
gs-1912	106	7	with	with	ADP
gs-1912	106	8	other	other	ADJ
gs-1912	106	9	substrates	substrate	NOUN
gs-1912	106	10	for	for	ADP
gs-1912	106	11	binding	bind	VERB
gs-1912	106	12	to	to	ADP
gs-1912	106	13	p	p	NOUN
gs-1912	106	14	-	-	PUNCT
gs-1912	106	15	gp	gp	NOUN
gs-1912	106	16	-	-	PUNCT
gs-1912	106	17	associated	associated	ADJ
gs-1912	106	18	atpase	atpase	PROPN
gs-1912	106	19	(	(	PUNCT
gs-1912	106	20	19	19	NUM
gs-1912	106	21	)	)	PUNCT
gs-1912	106	22	.	.	PUNCT
gs-1912	107	1	the	the	DET
gs-1912	107	2	influence	influence	NOUN
gs-1912	107	3	of	of	ADP
gs-1912	107	4	inhibitor	inhibitor	NOUN
gs-1912	107	5	on	on	ADP
gs-1912	107	6	the	the	DET
gs-1912	107	7	efflux	efflux	ADJ
gs-1912	107	8	ratios	ratio	NOUN
gs-1912	107	9	of	of	ADP
gs-1912	107	10	vingerbine	vingerbine	NOUN
gs-1912	107	11	constituent	constituent	NOUN
gs-1912	107	12	alkaloids	alkaloid	NOUN
gs-1912	107	13	across	across	ADP
gs-1912	107	14	caco-2	caco-2	NUM
gs-1912	107	15	cell	cell	NOUN
gs-1912	107	16	monolayers	monolayer	NOUN
gs-1912	107	17	is	be	AUX
gs-1912	107	18	shown	show	VERB
gs-1912	107	19	on	on	ADP
gs-1912	107	20	fig	fig	NOUN
gs-1912	107	21	4	4	NUM
gs-1912	107	22	.	.	PUNCT
gs-1912	108	1	the	the	DET
gs-1912	108	2	co	co	NOUN
gs-1912	108	3	-	-	NOUN
gs-1912	108	4	presence	presence	NOUN
gs-1912	108	5	of	of	ADP
gs-1912	108	6	p	p	NOUN
gs-1912	108	7	-	-	PUNCT
gs-1912	108	8	gp	gp	NOUN
gs-1912	108	9	inhibitor	inhibitor	NOUN
gs-1912	108	10	substantially	substantially	ADV
gs-1912	108	11	reduced	reduce	VERB
gs-1912	108	12	the	the	DET
gs-1912	108	13	basolateral	basolateral	NOUN
gs-1912	108	14	to	to	ADP
gs-1912	108	15	apical	apical	ADJ
gs-1912	108	16	efflux	efflux	NOUN
gs-1912	108	17	of	of	ADP
gs-1912	108	18	vincarine	vincarine	NOUN
gs-1912	108	19	and	and	CCONJ
gs-1912	108	20	herbadine	herbadine	VERB
gs-1912	108	21	and	and	CCONJ
gs-1912	108	22	significantly	significantly	ADV
gs-1912	108	23	increased	increase	VERB
gs-1912	108	24	the	the	DET
gs-1912	108	25	ab	ab	PROPN
gs-1912	108	26	-	-	PUNCT
gs-1912	108	27	bl	bl	PROPN
gs-1912	108	28	flux	flux	NOUN
gs-1912	108	29	,	,	PUNCT
gs-1912	108	30	thus	thus	ADV
gs-1912	108	31	provided	provide	VERB
gs-1912	108	32	supportive	supportive	ADJ
gs-1912	108	33	evidence	evidence	NOUN
gs-1912	108	34	for	for	ADP
gs-1912	108	35	the	the	DET
gs-1912	108	36	involvement	involvement	NOUN
gs-1912	108	37	of	of	ADP
gs-1912	108	38	an	an	DET
gs-1912	108	39	atp	atp	NOUN
gs-1912	108	40	-	-	PUNCT
gs-1912	108	41	dependent	dependent	ADJ
gs-1912	108	42	active	active	ADJ
gs-1912	108	43	mechanism	mechanism	NOUN
gs-1912	108	44	for	for	ADP
gs-1912	108	45	intestinal	intestinal	ADJ
gs-1912	108	46	transport	transport	NOUN
gs-1912	108	47	of	of	ADP
gs-1912	108	48	these	these	DET
gs-1912	108	49	compounds	compound	NOUN
gs-1912	108	50	;	;	PUNCT
gs-1912	108	51	on	on	ADP
gs-1912	108	52	the	the	DET
gs-1912	108	53	other	other	ADJ
gs-1912	108	54	hand	hand	NOUN
gs-1912	108	55	,	,	PUNCT
gs-1912	108	56	the	the	DET
gs-1912	108	57	insignificant	insignificant	ADJ
gs-1912	108	58	effect	effect	NOUN
gs-1912	108	59	of	of	ADP
gs-1912	108	60	verapamil	verapamil	NOUN
gs-1912	108	61	on	on	ADP
gs-1912	108	62	herbamine	herbamine	ADJ
gs-1912	108	63	and	and	CCONJ
gs-1912	108	64	vicamajine	vicamajine	PROPN
gs-1912	108	65	transport	transport	NOUN
gs-1912	108	66	indicated	indicate	VERB
gs-1912	108	67	a	a	DET
gs-1912	108	68	minor	minor	ADJ
gs-1912	108	69	role	role	NOUN
gs-1912	108	70	of	of	ADP
gs-1912	108	71	p	p	NOUN
gs-1912	108	72	-	-	PUNCT
gs-1912	108	73	gp	gp	NOUN
gs-1912	108	74	in	in	ADP
gs-1912	108	75	the	the	DET
gs-1912	108	76	oral	oral	ADJ
gs-1912	108	77	absorption	absorption	NOUN
gs-1912	108	78	of	of	ADP
gs-1912	108	79	these	these	DET
gs-1912	108	80	alkaloids	alkaloid	NOUN
gs-1912	108	81	and	and	CCONJ
gs-1912	108	82	excluded	exclude	VERB
gs-1912	108	83	them	they	PRON
gs-1912	108	84	as	as	ADP
gs-1912	108	85	a	a	DET
gs-1912	108	86	substrate	substrate	NOUN
gs-1912	108	87	for	for	ADP
gs-1912	108	88	p	p	NOUN
gs-1912	108	89	-	-	PUNCT
gs-1912	108	90	gp	gp	NOUN
gs-1912	108	91	.	.	PUNCT
gs-1912	109	1	these	these	DET
gs-1912	109	2	results	result	NOUN
gs-1912	109	3	are	be	AUX
gs-1912	109	4	compatible	compatible	ADJ
gs-1912	109	5	with	with	ADP
gs-1912	109	6	the	the	DET
gs-1912	109	7	data	datum	NOUN
gs-1912	109	8	obtained	obtain	VERB
gs-1912	109	9	earlier	early	ADV
gs-1912	109	10	from	from	ADP
gs-1912	109	11	rat	rat	ADJ
gs-1912	109	12	intestine	intestine	NOUN
gs-1912	109	13	model	model	NOUN
gs-1912	109	14	for	for	ADP
gs-1912	109	15	vingerbine	vingerbine	NOUN
gs-1912	109	16	constituent	constituent	NOUN
gs-1912	109	17	alkaloids	alkaloid	NOUN
gs-1912	109	18	(	(	PUNCT
gs-1912	109	19	15	15	NUM
gs-1912	109	20	)	)	PUNCT
gs-1912	109	21	.	.	PUNCT
gs-1912	110	1	georgian	georgian	ADJ
gs-1912	110	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-1912	110	3	მეცნიერები	მეცნიერები	NOUN
gs-1912	110	4	ტ.	ტ.	VERB
gs-1912	110	5	5	5	NUM
gs-1912	110	6	n	n	PRON
gs-1912	110	7	2	2	NUM
gs-1912	110	8	,	,	PUNCT
gs-1912	110	9	2023	2023	NUM
gs-1912	110	10	226	226	NUM
gs-1912	110	11	fig	fig	NOUN
gs-1912	110	12	.	.	PUNCT
gs-1912	111	1	4	4	X
gs-1912	111	2	.	.	X
gs-1912	111	3	paracelular	paracelular	ADJ
gs-1912	111	4	permeability	permeability	NOUN
gs-1912	111	5	dependence	dependence	NOUN
gs-1912	111	6	of	of	ADP
gs-1912	111	7	vingerbine	vingerbine	NOUN
gs-1912	111	8	constituent	constituent	NOUN
gs-1912	111	9	alkaloids	alkaloid	NOUN
gs-1912	111	10	transport	transport	NOUN
gs-1912	111	11	across	across	ADP
gs-1912	111	12	caco-2	caco-2	NUM
gs-1912	111	13	cell	cell	NOUN
gs-1912	111	14	monolayers	monolayer	NOUN
gs-1912	111	15	in	in	ADP
gs-1912	111	16	the	the	DET
gs-1912	111	17	presence	presence	NOUN
gs-1912	111	18	and	and	CCONJ
gs-1912	111	19	absence	absence	NOUN
gs-1912	111	20	of	of	ADP
gs-1912	111	21	verapamil	verapamil	NOUN
gs-1912	111	22	in	in	ADP
gs-1912	111	23	conclusion	conclusion	NOUN
gs-1912	111	24	,	,	PUNCT
gs-1912	111	25	vngerbine	vngerbine	NOUN
gs-1912	111	26	constituent	constituent	NOUN
gs-1912	111	27	alkaloids	alkaloid	NOUN
gs-1912	111	28	,	,	PUNCT
gs-1912	111	29	having	have	VERB
gs-1912	111	30	in	in	ADP
gs-1912	111	31	common	common	ADJ
gs-1912	111	32	certain	certain	ADJ
gs-1912	111	33	chemical	chemical	NOUN
gs-1912	111	34	and	and	CCONJ
gs-1912	111	35	physical	physical	ADJ
gs-1912	111	36	features	feature	NOUN
gs-1912	111	37	,	,	PUNCT
gs-1912	111	38	such	such	ADJ
gs-1912	111	39	as	as	ADP
gs-1912	111	40	hydrophobicity	hydrophobicity	NOUN
gs-1912	111	41	,	,	PUNCT
gs-1912	111	42	cationic	cationic	ADJ
gs-1912	111	43	charge	charge	NOUN
gs-1912	111	44	,	,	PUNCT
gs-1912	111	45	planar	planar	ADJ
gs-1912	111	46	aromatic	aromatic	ADJ
gs-1912	111	47	domain	domain	NOUN
gs-1912	111	48	and	and	CCONJ
gs-1912	111	49	nitrogen	nitrogen	NOUN
gs-1912	111	50	atom	atom	NOUN
gs-1912	111	51	,	,	PUNCT
gs-1912	111	52	demonstrated	demonstrate	VERB
gs-1912	111	53	different	different	ADJ
gs-1912	111	54	permeability	permeability	NOUN
gs-1912	111	55	properties	property	NOUN
gs-1912	111	56	across	across	ADP
gs-1912	111	57	caco-2	caco-2	NUM
gs-1912	111	58	cells	cell	NOUN
gs-1912	111	59	.	.	PUNCT
gs-1912	112	1	vincarine	vincarine	VERB
gs-1912	112	2	and	and	CCONJ
gs-1912	112	3	herbadine	herbadine	ADJ
gs-1912	112	4	,	,	PUNCT
gs-1912	112	5	bearing	bear	VERB
gs-1912	112	6	hydrogen	hydrogen	NOUN
gs-1912	112	7	atom	atom	NOUN
gs-1912	112	8	at	at	ADP
gs-1912	112	9	first	first	ADJ
gs-1912	112	10	position	position	NOUN
gs-1912	112	11	(	(	PUNCT
gs-1912	112	12	n	n	CCONJ
gs-1912	112	13	-	-	PUNCT
gs-1912	112	14	h	h	NOUN
gs-1912	112	15	)	)	PUNCT
gs-1912	112	16	,	,	PUNCT
gs-1912	112	17	have	have	VERB
gs-1912	112	18	typical	typical	ADJ
gs-1912	112	19	p	p	NOUN
gs-1912	112	20	-	-	PUNCT
gs-1912	112	21	gp	gp	NOUN
gs-1912	112	22	-	-	PUNCT
gs-1912	112	23	involved	involve	VERB
gs-1912	112	24	transport	transport	NOUN
gs-1912	112	25	properties	property	NOUN
gs-1912	112	26	including	include	VERB
gs-1912	112	27	preferential	preferential	ADJ
gs-1912	112	28	transport	transport	NOUN
gs-1912	112	29	in	in	ADP
gs-1912	112	30	the	the	DET
gs-1912	112	31	basolateral	basolateral	NOUN
gs-1912	112	32	to	to	ADP
gs-1912	112	33	apical	apical	ADJ
gs-1912	112	34	direction	direction	NOUN
gs-1912	112	35	;	;	PUNCT
gs-1912	112	36	meanwhile	meanwhile	ADV
gs-1912	112	37	,	,	PUNCT
gs-1912	112	38	in	in	ADP
gs-1912	112	39	the	the	DET
gs-1912	112	40	transport	transport	NOUN
gs-1912	112	41	of	of	ADP
gs-1912	112	42	herbamine	herbamine	ADJ
gs-1912	112	43	and	and	CCONJ
gs-1912	112	44	vincamajine	vincamajine	ADJ
gs-1912	112	45	,	,	PUNCT
gs-1912	112	46	possessing	possess	VERB
gs-1912	112	47	methyl	methyl	NOUN
gs-1912	112	48	group	group	NOUN
gs-1912	112	49	(	(	PUNCT
gs-1912	112	50	n	n	CCONJ
gs-1912	112	51	-	-	PUNCT
gs-1912	112	52	ch3	ch3	NOUN
gs-1912	112	53	)	)	PUNCT
gs-1912	112	54	,	,	PUNCT
gs-1912	112	55	pgp	pgp	PROPN
gs-1912	112	56	/	/	SYM
gs-1912	112	57	mdr1	mdr1	PROPN
gs-1912	112	58	played	play	VERB
gs-1912	112	59	a	a	DET
gs-1912	112	60	minor	minor	ADJ
gs-1912	112	61	role	role	NOUN
gs-1912	112	62	.	.	PUNCT
gs-1912	113	1	strong	strong	ADJ
gs-1912	113	2	relationship	relationship	NOUN
gs-1912	113	3	has	have	AUX
gs-1912	113	4	been	be	AUX
gs-1912	113	5	observed	observe	VERB
gs-1912	113	6	between	between	ADP
gs-1912	113	7	the	the	DET
gs-1912	113	8	lipid	lipid	NOUN
gs-1912	113	9	solubility	solubility	NOUN
gs-1912	113	10	of	of	ADP
gs-1912	113	11	compound	compound	NOUN
gs-1912	113	12	and	and	CCONJ
gs-1912	113	13	its	its	PRON
gs-1912	113	14	affinity	affinity	NOUN
gs-1912	113	15	for	for	ADP
gs-1912	113	16	p	p	NOUN
gs-1912	113	17	-	-	PUNCT
gs-1912	113	18	gp	gp	NOUN
gs-1912	113	19	;	;	PUNCT
gs-1912	113	20	more	more	ADV
gs-1912	113	21	hydrophobic	hydrophobic	NOUN
gs-1912	113	22	vincarine	vincarine	NOUN
gs-1912	113	23	expressed	express	VERB
gs-1912	113	24	more	more	ADJ
gs-1912	113	25	effectiveness	effectiveness	NOUN
gs-1912	113	26	for	for	ADP
gs-1912	113	27	interaction	interaction	NOUN
gs-1912	113	28	with	with	ADP
gs-1912	113	29	p	p	NOUN
gs-1912	113	30	-	-	PUNCT
gs-1912	113	31	gp	gp	NOUN
gs-1912	113	32	.	.	PUNCT
gs-1912	114	1	due	due	ADP
gs-1912	114	2	to	to	ADP
gs-1912	114	3	the	the	DET
gs-1912	114	4	involvement	involvement	NOUN
gs-1912	114	5	of	of	ADP
gs-1912	114	6	p	p	NOUN
gs-1912	114	7	-	-	PUNCT
gs-1912	114	8	pg	pg	NOUN
gs-1912	114	9	in	in	ADP
gs-1912	114	10	vingerbine	vingerbine	NOUN
gs-1912	114	11	transport	transport	NOUN
gs-1912	114	12	,	,	PUNCT
gs-1912	114	13	the	the	DET
gs-1912	114	14	further	further	ADJ
gs-1912	114	15	studies	study	NOUN
gs-1912	114	16	will	will	AUX
gs-1912	114	17	be	be	AUX
gs-1912	114	18	focused	focus	VERB
gs-1912	114	19	upon	upon	SCONJ
gs-1912	114	20	the	the	DET
gs-1912	114	21	screening	screen	VERB
gs-1912	114	22	appropriate	appropriate	ADJ
gs-1912	114	23	nanomedicine	nanomedicine	NOUN
gs-1912	114	24	-	-	PUNCT
gs-1912	114	25	based	base	VERB
gs-1912	114	26	strategies	strategy	NOUN
gs-1912	114	27	to	to	PART
gs-1912	114	28	combat	combat	VERB
gs-1912	114	29	mdr	mdr	PROPN
gs-1912	114	30	and	and	CCONJ
gs-1912	114	31	thus	thus	ADV
gs-1912	114	32	improve	improve	VERB
gs-1912	114	33	intestinal	intestinal	ADJ
gs-1912	114	34	absorption	absorption	NOUN
gs-1912	114	35	of	of	ADP
gs-1912	114	36	anti	anti	ADJ
gs-1912	114	37	-	-	ADJ
gs-1912	114	38	arrhythmic	arrhythmic	ADJ
gs-1912	114	39	alkaloids	alkaloid	NOUN
gs-1912	114	40	.	.	PUNCT
gs-1912	115	1	acknowledgements	acknowledgement	NOUN
gs-1912	115	2	.	.	PUNCT
gs-1912	116	1	this	this	DET
gs-1912	116	2	work	work	NOUN
gs-1912	116	3	was	be	AUX
gs-1912	116	4	supported	support	VERB
gs-1912	116	5	by	by	ADP
gs-1912	116	6	grant	grant	NOUN
gs-1912	116	7	:	:	PUNCT
gs-1912	116	8	nord	nord	ADJ
gs-1912	116	9	-	-	PUNCT
gs-1912	116	10	süd	süd	NOUN
gs-1912	116	11	-	-	PUNCT
gs-1912	116	12	dialog	dialog	NOUN
gs-1912	116	13	-	-	PUNCT
gs-1912	116	14	stipendien	stipendien	NOUN
gs-1912	116	15	programm	programm	NOUN
gs-1912	116	16	2005/06	2005/06	NUM
gs-1912	116	17	(	(	PUNCT
gs-1912	116	18	zl	zl	PROPN
gs-1912	116	19	.	.	PROPN
gs-1912	116	20	:	:	PUNCT
gs-1912	117	1	202	202	NUM
gs-1912	117	2	-	-	SYM
gs-1912	117	3	3	3	NUM
gs-1912	117	4	/	/	SYM
gs-1912	117	5	eza/2005	eza/2005	PRON
gs-1912	117	6	)	)	PUNCT
gs-1912	117	7	financed	finance	VERB
gs-1912	117	8	out	out	ADP
gs-1912	117	9	of	of	ADP
gs-1912	117	10	the	the	DET
gs-1912	117	11	means	mean	NOUN
gs-1912	117	12	of	of	ADP
gs-1912	117	13	the	the	DET
gs-1912	117	14	austrian	austrian	ADJ
gs-1912	117	15	development	development	NOUN
gs-1912	117	16	cooperation	cooperation	NOUN
gs-1912	117	17	(	(	PUNCT
gs-1912	117	18	austrian	austrian	ADJ
gs-1912	117	19	exchange	exchange	NOUN
gs-1912	117	20	service	service	NOUN
gs-1912	117	21	agency	agency	NOUN
gs-1912	117	22	for	for	ADP
gs-1912	117	23	international	international	ADJ
gs-1912	117	24	cooperation	cooperation	NOUN
gs-1912	117	25	in	in	ADP
gs-1912	117	26	education	education	NOUN
gs-1912	117	27	and	and	CCONJ
gs-1912	117	28	research	research	PROPN
gs-1912	117	29	acm	acm	PROPN
gs-1912	117	30	)	)	PUNCT
gs-1912	117	31	to	to	ADP
gs-1912	117	32	lia	lia	PROPN
gs-1912	117	33	tsiklauri	tsiklauri	PROPN
gs-1912	117	34	.	.	PUNCT
gs-1912	118	1	references	reference	NOUN
gs-1912	118	2	1	1	NUM
gs-1912	118	3	.	.	PUNCT
gs-1912	118	4	pham	pham	PROPN
gs-1912	118	5	hnt	hnt	PROPN
gs-1912	118	6	,	,	PUNCT
gs-1912	118	7	vuong	vuong	PROPN
gs-1912	118	8	qv	qv	PROPN
gs-1912	118	9	,	,	PUNCT
gs-1912	118	10	bowyer	bowyer	PROPN
gs-1912	118	11	mc	mc	PROPN
gs-1912	118	12	,	,	PUNCT
gs-1912	118	13	scarlett	scarlett	PROPN
gs-1912	118	14	cj	cj	PROPN
gs-1912	118	15	.	.	PUNCT
gs-1912	119	1	phytochemicals	phytochemical	NOUN
gs-1912	119	2	derived	derive	VERB
gs-1912	119	3	from	from	ADP
gs-1912	119	4	catharanthus	catharanthus	NOUN
gs-1912	119	5	roseus	roseus	NOUN
gs-1912	119	6	and	and	CCONJ
gs-1912	119	7	their	their	PRON
gs-1912	119	8	health	health	NOUN
gs-1912	119	9	benefits	benefit	NOUN
gs-1912	119	10	.	.	PUNCT
gs-1912	120	1	technologies	technology	NOUN
gs-1912	120	2	.	.	PUNCT
gs-1912	121	1	2020	2020	NUM
gs-1912	121	2	;	;	PUNCT
gs-1912	121	3	8(4):80	8(4):80	NUM
gs-1912	121	4	.	.	PUNCT
gs-1912	122	1	georgian	georgian	ADJ
gs-1912	122	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-1912	122	3	მეცნიერები	მეცნიერები	NOUN
gs-1912	122	4	ტ.	ტ.	VERB
gs-1912	122	5	5	5	NUM
gs-1912	122	6	n	n	DET
gs-1912	122	7	2	2	NUM
gs-1912	122	8	,	,	PUNCT
gs-1912	122	9	2023	2023	NUM
gs-1912	122	10	227	227	NUM
gs-1912	122	11	2	2	NUM
gs-1912	122	12	.	.	PUNCT
gs-1912	123	1	iqbal	iqbal	PROPN
gs-1912	123	2	s	s	PROPN
gs-1912	123	3	,	,	PUNCT
gs-1912	123	4	flux	flux	PROPN
gs-1912	123	5	c	c	PROPN
gs-1912	123	6	,	,	PUNCT
gs-1912	123	7	briggs	briggs	PROPN
gs-1912	123	8	da	da	PROPN
gs-1912	123	9	,	,	PUNCT
gs-1912	123	10	et	et	PROPN
gs-1912	123	11	al	al	PROPN
gs-1912	123	12	.	.	PROPN
gs-1912	123	13	vinca	vinca	PROPN
gs-1912	123	14	alkaloid	alkaloid	NOUN
gs-1912	123	15	binding	bind	VERB
gs-1912	123	16	to	to	ADP
gs-1912	123	17	p	p	NOUN
gs-1912	123	18	-	-	PUNCT
gs-1912	123	19	glycoprotein	glycoprotein	NOUN
gs-1912	123	20	occurs	occur	VERB
gs-1912	123	21	in	in	ADP
gs-1912	123	22	a	a	DET
gs-1912	123	23	processive	processive	ADJ
gs-1912	123	24	manner	manner	NOUN
gs-1912	123	25	.	.	PUNCT
gs-1912	124	1	biochim	biochim	PROPN
gs-1912	124	2	biophys	biophy	NOUN
gs-1912	124	3	acta	acta	PROPN
gs-1912	124	4	biomembr	biomembr	NOUN
gs-1912	124	5	.	.	PUNCT
gs-1912	125	1	2022;1864(10	2022;1864(10	NUM
gs-1912	125	2	):	):	PUNCT
gs-1912	125	3	iqbal	iqbal	PROPN
gs-1912	125	4	s	s	PROPN
gs-1912	125	5	,	,	PUNCT
gs-1912	125	6	flux	flux	PROPN
gs-1912	125	7	c	c	PROPN
gs-1912	125	8	,	,	PUNCT
gs-1912	125	9	briggs	briggs	PROPN
gs-1912	125	10	da	da	PROPN
gs-1912	125	11	,	,	PUNCT
gs-1912	125	12	et	et	PROPN
gs-1912	125	13	al	al	PROPN
gs-1912	125	14	.	.	PROPN
gs-1912	125	15	vinca	vinca	PROPN
gs-1912	125	16	alkaloid	alkaloid	NOUN
gs-1912	125	17	binding	bind	VERB
gs-1912	125	18	to	to	ADP
gs-1912	125	19	p	p	NOUN
gs-1912	125	20	-	-	PUNCT
gs-1912	125	21	glycoprotein	glycoprotein	NOUN
gs-1912	125	22	occurs	occur	VERB
gs-1912	125	23	in	in	ADP
gs-1912	125	24	a	a	DET
gs-1912	125	25	processive	processive	ADJ
gs-1912	125	26	manner	manner	NOUN
gs-1912	125	27	.	.	PUNCT
gs-1912	126	1	biochim	biochim	PROPN
gs-1912	126	2	biophys	biophy	NOUN
gs-1912	126	3	acta	acta	PROPN
gs-1912	126	4	biomembr	biomembr	NOUN
gs-1912	126	5	.	.	PUNCT
gs-1912	127	1	2022;1864(10	2022;1864(10	NUM
gs-1912	127	2	)	)	PUNCT
gs-1912	127	3	.	.	PUNCT
gs-1912	128	1	3	3	X
gs-1912	128	2	.	.	X
gs-1912	128	3	mollazadeh	mollazadeh	PROPN
gs-1912	128	4	s	s	PROPN
gs-1912	128	5	,	,	PUNCT
gs-1912	128	6	sahebkar	sahebkar	PROPN
gs-1912	128	7	a	a	PRON
gs-1912	128	8	,	,	PUNCT
gs-1912	128	9	hadizadeh	hadizadeh	NOUN
gs-1912	128	10	f	f	NOUN
gs-1912	128	11	,	,	PUNCT
gs-1912	128	12	behravan	behravan	PROPN
gs-1912	128	13	j	j	PROPN
gs-1912	128	14	,	,	PUNCT
gs-1912	128	15	arabzadeh	arabzadeh	ADV
gs-1912	128	16	s.	s.	PROPN
gs-1912	128	17	structural	structural	ADJ
gs-1912	128	18	and	and	CCONJ
gs-1912	128	19	functional	functional	ADJ
gs-1912	128	20	aspects	aspect	NOUN
gs-1912	128	21	of	of	ADP
gs-1912	128	22	p	p	NOUN
gs-1912	128	23	-	-	PUNCT
gs-1912	128	24	glycoprotein	glycoprotein	NOUN
gs-1912	128	25	and	and	CCONJ
gs-1912	128	26	its	its	PRON
gs-1912	128	27	inhibitors	inhibitor	NOUN
gs-1912	128	28	.	.	PUNCT
gs-1912	129	1	life	life	PROPN
gs-1912	129	2	sci	sci	PROPN
gs-1912	129	3	.	.	PUNCT
gs-1912	129	4	2018;214:118	2018;214:118	NUM
gs-1912	129	5	-	-	SYM
gs-1912	129	6	123	123	NUM
gs-1912	129	7	.	.	PUNCT
gs-1912	130	1	4	4	X
gs-1912	130	2	.	.	X
gs-1912	130	3	mora	mora	PROPN
gs-1912	130	4	lagares	lagares	PROPN
gs-1912	130	5	l	l	PROPN
gs-1912	130	6	,	,	PUNCT
gs-1912	130	7	minovski	minovski	ADJ
gs-1912	130	8	n	n	CCONJ
gs-1912	130	9	,	,	PUNCT
gs-1912	130	10	novič	novič	ADJ
gs-1912	130	11	m.	m.	NOUN
gs-1912	130	12	multiclass	multiclass	ADJ
gs-1912	130	13	classifier	classifier	NOUN
gs-1912	130	14	for	for	ADP
gs-1912	130	15	p	p	NOUN
gs-1912	130	16	-	-	PUNCT
gs-1912	130	17	glycoprotein	glycoprotein	NOUN
gs-1912	130	18	substrates	substrate	NOUN
gs-1912	130	19	,	,	PUNCT
gs-1912	130	20	inhibitors	inhibitor	NOUN
gs-1912	130	21	,	,	PUNCT
gs-1912	130	22	and	and	CCONJ
gs-1912	130	23	non	non	ADJ
gs-1912	130	24	-	-	ADJ
gs-1912	130	25	active	active	ADJ
gs-1912	130	26	compounds	compound	NOUN
gs-1912	130	27	.	.	PUNCT
gs-1912	131	1	molecules	molecule	NOUN
gs-1912	131	2	.	.	PUNCT
gs-1912	132	1	2019;24(10):2006	2019;24(10):2006	NUM
gs-1912	132	2	.	.	NOUN
gs-1912	132	3	5	5	NUM
gs-1912	132	4	.	.	X
gs-1912	132	5	frezard	frezard	PROPN
gs-1912	132	6	f.	f.	PROPN
gs-1912	132	7	,	,	PUNCT
gs-1912	132	8	pereira	pereira	PROPN
gs-1912	132	9	-	-	PUNCT
gs-1912	132	10	maia	maia	PROPN
gs-1912	132	11	e.	e.	PROPN
gs-1912	132	12	,	,	PUNCT
gs-1912	132	13	quidu	quidu	PROPN
gs-1912	132	14	p.	p.	NOUN
gs-1912	132	15	,	,	PUNCT
gs-1912	132	16	priebe	priebe	PROPN
gs-1912	132	17	w.	w.	PROPN
gs-1912	132	18	,	,	PUNCT
gs-1912	132	19	garnier	garnier	PROPN
gs-1912	132	20	-	-	PUNCT
gs-1912	132	21	suillerot	suillerot	NOUN
gs-1912	132	22	a.	a.	NOUN
gs-1912	132	23	p	p	NOUN
gs-1912	132	24	-	-	PUNCT
gs-1912	132	25	glycoprotein	glycoprotein	NOUN
gs-1912	132	26	preferentially	preferentially	ADV
gs-1912	132	27	effluxes	effluxe	VERB
gs-1912	132	28	anthracyclines	anthracycline	NOUN
gs-1912	132	29	containing	contain	VERB
gs-1912	132	30	free	free	ADJ
gs-1912	132	31	basic	basic	ADJ
gs-1912	132	32	versus	versus	ADP
gs-1912	132	33	charged	charge	VERB
gs-1912	132	34	amine	amine	NOUN
gs-1912	132	35	.	.	PUNCT
gs-1912	133	1	eur	eur	PROPN
gs-1912	133	2	.	.	PUNCT
gs-1912	134	1	j.	j.	PROPN
gs-1912	134	2	biochem	biochem	PROPN
gs-1912	134	3	.	.	PUNCT
gs-1912	135	1	2001	2001	NUM
gs-1912	135	2	,	,	PUNCT
gs-1912	135	3	268:1561	268:1561	NUM
gs-1912	135	4	-	-	SYM
gs-1912	135	5	1567	1567	NUM
gs-1912	135	6	6	6	NUM
gs-1912	135	7	.	.	PUNCT
gs-1912	136	1	vachnadze	vachnadze	PROPN
gs-1912	136	2	vyu	vyu	NOUN
gs-1912	136	3	.	.	PUNCT
gs-1912	137	1	vinca	vinca	NOUN
gs-1912	137	2	alkaloids	alkaloid	NOUN
gs-1912	137	3	,	,	PUNCT
gs-1912	137	4	their	their	PRON
gs-1912	137	5	accumulation	accumulation	NOUN
gs-1912	137	6	dynamics	dynamic	NOUN
gs-1912	137	7	and	and	CCONJ
gs-1912	137	8	formation	formation	NOUN
gs-1912	137	9	in	in	ADP
gs-1912	137	10	plants	plant	NOUN
gs-1912	137	11	.	.	PUNCT
gs-1912	138	1	doctoral	doctoral	ADJ
gs-1912	138	2	dissertation	dissertation	NOUN
gs-1912	138	3	.	.	PUNCT
gs-1912	139	1	tbilisi	tbilisi	PROPN
gs-1912	139	2	(	(	PUNCT
gs-1912	139	3	moscow	moscow	PROPN
gs-1912	139	4	)	)	PUNCT
gs-1912	139	5	,	,	PUNCT
gs-1912	139	6	1973	1973	NUM
gs-1912	139	7	:	:	PUNCT
gs-1912	139	8	176	176	NUM
gs-1912	139	9	.	.	X
gs-1912	140	1	7	7	X
gs-1912	140	2	.	.	X
gs-1912	140	3	chkhikvadze	chkhikvadze	PROPN
gs-1912	140	4	gv	gv	PROPN
gs-1912	140	5	.	.	PUNCT
gs-1912	140	6	alkaloids	alkaloid	NOUN
gs-1912	140	7	of	of	ADP
gs-1912	140	8	vinca	vinca	NOUN
gs-1912	140	9	herbacea	herbacea	PROPN
gs-1912	140	10	w.	w.	PROPN
gs-1912	140	11	et	et	PROPN
gs-1912	140	12	kit	kit	PROPN
gs-1912	140	13	.	.	PUNCT
gs-1912	141	1	and	and	CCONJ
gs-1912	141	2	vinca	vinca	ADJ
gs-1912	141	3	pubescens	pubescen	NOUN
gs-1912	141	4	urv	urv	PROPN
gs-1912	141	5	.	.	PROPN
gs-1912	141	6	cultivated	cultivate	VERB
gs-1912	141	7	in	in	ADP
gs-1912	141	8	georgia	georgia	PROPN
gs-1912	141	9	.	.	PUNCT
gs-1912	142	1	ph.d	ph.d	PROPN
gs-1912	142	2	thesis	thesis	PROPN
gs-1912	142	3	.	.	PUNCT
gs-1912	143	1	tbilisi	tbilisi	PROPN
gs-1912	143	2	(	(	PUNCT
gs-1912	143	3	moscow	moscow	PROPN
gs-1912	143	4	)	)	PUNCT
gs-1912	143	5	,	,	PUNCT
gs-1912	143	6	1989	1989	NUM
gs-1912	143	7	:	:	PUNCT
gs-1912	143	8	120	120	NUM
gs-1912	143	9	.	.	NOUN
gs-1912	143	10	8	8	NUM
gs-1912	143	11	.	.	PUNCT
gs-1912	143	12	dzhakeli	dzhakeli	PROPN
gs-1912	143	13	ez	ez	PROPN
gs-1912	143	14	.	.	PROPN
gs-1912	143	15	alkaloids	alkaloid	NOUN
gs-1912	143	16	from	from	ADP
gs-1912	143	17	the	the	DET
gs-1912	143	18	roots	root	NOUN
gs-1912	143	19	of	of	ADP
gs-1912	143	20	vinca	vinca	ADJ
gs-1912	143	21	herbacea	herbacea	PROPN
gs-1912	143	22	w.	w.	PROPN
gs-1912	143	23	et	et	PROPN
gs-1912	143	24	kit	kit	PROPN
gs-1912	143	25	.	.	PUNCT
gs-1912	144	1	growing	grow	VERB
gs-1912	144	2	and	and	CCONJ
gs-1912	144	3	cultivated	cultivate	VERB
gs-1912	144	4	in	in	ADP
gs-1912	144	5	georgia	georgia	PROPN
gs-1912	144	6	.	.	PUNCT
gs-1912	145	1	ph.d	ph.d	PROPN
gs-1912	145	2	thesis	thesis	PROPN
gs-1912	145	3	.	.	PUNCT
gs-1912	146	1	tbilisi	tbilisi	PROPN
gs-1912	146	2	,	,	PUNCT
gs-1912	146	3	2004	2004	NUM
gs-1912	146	4	:	:	PUNCT
gs-1912	147	1	133	133	NUM
gs-1912	147	2	.	.	NOUN
gs-1912	147	3	9	9	NUM
gs-1912	147	4	.	.	X
gs-1912	148	1	vachnadze	vachnadze	NOUN
gs-1912	148	2	vyu	vyu	INTJ
gs-1912	148	3	.	.	PUNCT
gs-1912	148	4	,	,	PUNCT
gs-1912	148	5	malikov	malikov	PROPN
gs-1912	148	6	vm	vm	PROPN
gs-1912	148	7	.	.	PROPN
gs-1912	148	8	,	,	PUNCT
gs-1912	148	9	mudzhiri	mudzhiri	PROPN
gs-1912	148	10	ks	ks	PROPN
gs-1912	148	11	and	and	CCONJ
gs-1912	148	12	yunusov	yunusov	PROPN
gs-1912	148	13	syu	syu	PROPN
gs-1912	148	14	.	.	PUNCT
gs-1912	149	1	structure	structure	NOUN
gs-1912	149	2	of	of	ADP
gs-1912	149	3	herbadine	herbadine	ADJ
gs-1912	149	4	and	and	CCONJ
gs-1912	149	5	herbamine	herbamine	ADJ
gs-1912	149	6	.	.	PUNCT
gs-1912	150	1	khimiya	khimiya	PROPN
gs-1912	150	2	prirodnykh	prirodnykh	PROPN
gs-1912	150	3	soedinenii	soedinenii	NOUN
gs-1912	150	4	1972	1972	NUM
gs-1912	150	5	:	:	PUNCT
gs-1912	150	6	341	341	NUM
gs-1912	150	7	.	.	NOUN
gs-1912	150	8	10	10	NUM
gs-1912	150	9	.	.	PUNCT
gs-1912	151	1	chkhikvadze	chkhikvadze	PROPN
gs-1912	151	2	gv	gv	PROPN
gs-1912	151	3	,	,	PUNCT
gs-1912	151	4	vatchnadze	vatchnadze	ADJ
gs-1912	151	5	vj	vj	PROPN
gs-1912	151	6	,	,	PUNCT
gs-1912	151	7	gambashidze	gambashidze	PROPN
gs-1912	151	8	nb	nb	PROPN
gs-1912	151	9	,	,	PUNCT
gs-1912	151	10	gvishiani	gvishiani	PROPN
gs-1912	151	11	ef	ef	PROPN
gs-1912	151	12	,	,	PUNCT
gs-1912	151	13	mudzhiri	mudzhiri	PROPN
gs-1912	151	14	ls	ls	PROPN
gs-1912	151	15	.	.	PROPN
gs-1912	152	1	reception	reception	PROPN
gs-1912	152	2	method	method	NOUN
gs-1912	152	3	of	of	ADP
gs-1912	152	4	anti	anti	ADJ
gs-1912	152	5	-	-	ADJ
gs-1912	152	6	arrhythmic	arrhythmic	ADJ
gs-1912	152	7	substance	substance	NOUN
gs-1912	152	8	.	.	PUNCT
gs-1912	153	1	pat	pat	PROPN
gs-1912	153	2	.	.	PROPN
gs-1912	154	1	n	n	PROPN
gs-1912	154	2	834964	834964	NUM
gs-1912	154	3	a61	a61	PROPN
gs-1912	154	4	k	k	PROPN
gs-1912	154	5	35/78	35/78	NUM
gs-1912	154	6	.	.	PUNCT
gs-1912	154	7	1981	1981	NUM
gs-1912	154	8	.	.	PUNCT
gs-1912	155	1	11	11	NUM
gs-1912	155	2	.	.	PUNCT
gs-1912	156	1	chkhikvadze	chkhikvadze	PROPN
gs-1912	156	2	gv	gv	ADP
gs-1912	156	3	,	,	PUNCT
gs-1912	156	4	gambashidze	gambashidze	PROPN
gs-1912	156	5	nb	nb	PROPN
gs-1912	156	6	,	,	PUNCT
gs-1912	156	7	gvishiani	gvishiani	PROPN
gs-1912	156	8	ef	ef	PROPN
gs-1912	156	9	,	,	PUNCT
gs-1912	156	10	vatchnadze	vatchnadze	PROPN
gs-1912	156	11	vj	vj	PROPN
gs-1912	156	12	,	,	PUNCT
gs-1912	156	13	giorgadze	giorgadze	PROPN
gs-1912	156	14	ni	ni	PROPN
gs-1912	156	15	.	.	PROPN
gs-1912	156	16	chemical	chemical	PROPN
gs-1912	156	17	and	and	CCONJ
gs-1912	156	18	pharmacological	pharmacological	ADJ
gs-1912	156	19	investigation	investigation	NOUN
gs-1912	156	20	of	of	ADP
gs-1912	156	21	vinca	vinca	ADJ
gs-1912	156	22	herbacea	herbacea	PROPN
gs-1912	156	23	w.	w.	PROPN
gs-1912	156	24	et	et	PROPN
gs-1912	156	25	kit	kit	PROPN
gs-1912	156	26	.	.	PUNCT
gs-1912	157	1	all	all	PROPN
gs-1912	157	2	-	-	PUNCT
gs-1912	157	3	union	union	NOUN
gs-1912	157	4	conference	conference	NOUN
gs-1912	157	5	“	"	PUNCT
gs-1912	157	6	development	development	NOUN
gs-1912	157	7	,	,	PUNCT
gs-1912	157	8	investigation	investigation	NOUN
gs-1912	157	9	and	and	CCONJ
gs-1912	157	10	complex	complex	ADJ
gs-1912	157	11	use	use	NOUN
gs-1912	157	12	of	of	ADP
gs-1912	157	13	preparations	preparation	NOUN
gs-1912	157	14	applicable	applicable	ADJ
gs-1912	157	15	for	for	ADP
gs-1912	157	16	cardio	cardio	NOUN
gs-1912	157	17	-	-	PUNCT
gs-1912	157	18	vascular	vascular	ADJ
gs-1912	157	19	diseases	disease	NOUN
gs-1912	157	20	”	"	PUNCT
gs-1912	157	21	.	.	PUNCT
gs-1912	158	1	tbilisi,1982:28	tbilisi,1982:28	PROPN
gs-1912	158	2	-	-	PUNCT
gs-1912	158	3	29	29	NUM
gs-1912	158	4	12	12	NUM
gs-1912	158	5	.	.	PUNCT
gs-1912	159	1	novicova	novicova	PROPN
gs-1912	159	2	jn	jn	PROPN
gs-1912	159	3	,	,	PUNCT
gs-1912	159	4	gociredze	gociredze	PROPN
gs-1912	159	5	ia	ia	PROPN
gs-1912	159	6	,	,	PUNCT
gs-1912	159	7	abuladze	abuladze	VERB
gs-1912	159	8	gv	gv	ADP
gs-1912	159	9	.	.	PUNCT
gs-1912	159	10	comparative	comparative	ADJ
gs-1912	159	11	investigation	investigation	NOUN
gs-1912	159	12	of	of	ADP
gs-1912	159	13	pharmacological	pharmacological	ADJ
gs-1912	159	14	activity	activity	NOUN
gs-1912	159	15	of	of	ADP
gs-1912	159	16	individual	individual	ADJ
gs-1912	159	17	alkaloids	alkaloid	NOUN
gs-1912	159	18	and	and	CCONJ
gs-1912	159	19	their	their	PRON
gs-1912	159	20	sum	sum	NOUN
gs-1912	159	21	isolated	isolate	VERB
gs-1912	159	22	from	from	ADP
gs-1912	159	23	vinca	vinca	PROPN
gs-1912	159	24	herbacea	herbacea	PROPN
gs-1912	159	25	w.	w.	PROPN
gs-1912	159	26	et	et	PROPN
gs-1912	159	27	kit.pnoc	kit.pnoc	PROPN
gs-1912	159	28	.	.	PUNCT
gs-1912	160	1	a.s	a.s	PROPN
gs-1912	160	2	.	.	PROPN
gs-1912	160	3	gssr	gssr	PROPN
gs-1912	160	4	;	;	PUNCT
gs-1912	160	5	biol	biol	PROPN
gs-1912	160	6	.	.	PUNCT
gs-1912	161	1	1984	1984	NUM
gs-1912	161	2	,	,	PUNCT
gs-1912	161	3	10	10	NUM
gs-1912	161	4	(	(	PUNCT
gs-1912	161	5	1):54	1):54	NUM
gs-1912	161	6	-	-	SYM
gs-1912	161	7	56	56	NUM
gs-1912	161	8	13	13	NUM
gs-1912	161	9	.	.	PUNCT
gs-1912	162	1	van	van	PROPN
gs-1912	162	2	breemen	breeman	NOUN
gs-1912	162	3	rb	rb	PROPN
gs-1912	162	4	,	,	PUNCT
gs-1912	162	5	li	li	PROPN
gs-1912	162	6	y.	y.	PROPN
gs-1912	162	7	caco-2	caco-2	PROPN
gs-1912	162	8	cell	cell	NOUN
gs-1912	162	9	permeability	permeability	NOUN
gs-1912	162	10	assays	assay	NOUN
gs-1912	162	11	to	to	PART
gs-1912	162	12	measure	measure	VERB
gs-1912	162	13	drug	drug	NOUN
gs-1912	162	14	absorption	absorption	NOUN
gs-1912	162	15	.	.	PUNCT
gs-1912	163	1	expert	expert	NOUN
gs-1912	163	2	opin	opin	NOUN
gs-1912	163	3	drug	drug	NOUN
gs-1912	163	4	metab	metab	NOUN
gs-1912	163	5	toxicol	toxicol	NOUN
gs-1912	163	6	.	.	PUNCT
gs-1912	164	1	2005;1(2):175	2005;1(2):175	NUM
gs-1912	164	2	-	-	SYM
gs-1912	164	3	185	185	NUM
gs-1912	164	4	.	.	PUNCT
gs-1912	165	1	14	14	NUM
gs-1912	165	2	.	.	PUNCT
gs-1912	166	1	artursson	artursson	PROPN
gs-1912	166	2	p	p	PROPN
gs-1912	166	3	,	,	PUNCT
gs-1912	166	4	magnusson	magnusson	PROPN
gs-1912	166	5	c.	c.	PROPN
gs-1912	166	6	epithelial	epithelial	ADJ
gs-1912	166	7	transport	transport	NOUN
gs-1912	166	8	of	of	ADP
gs-1912	166	9	drugs	drug	NOUN
gs-1912	166	10	in	in	ADP
gs-1912	166	11	cell	cell	NOUN
gs-1912	166	12	culture	culture	NOUN
gs-1912	166	13	.	.	PUNCT
gs-1912	167	1	ii	ii	NOUN
gs-1912	167	2	:	:	PUNCT
gs-1912	167	3	effect	effect	NOUN
gs-1912	167	4	of	of	ADP
gs-1912	167	5	extracellular	extracellular	ADJ
gs-1912	167	6	calcium	calcium	NOUN
gs-1912	167	7	concentration	concentration	NOUN
gs-1912	167	8	on	on	ADP
gs-1912	167	9	the	the	DET
gs-1912	167	10	paracellular	paracellular	ADJ
gs-1912	167	11	transport	transport	NOUN
gs-1912	167	12	of	of	ADP
gs-1912	167	13	drugs	drug	NOUN
gs-1912	167	14	of	of	ADP
gs-1912	167	15	different	different	ADJ
gs-1912	167	16	lipophilicities	lipophilicitie	NOUN
gs-1912	167	17	across	across	ADP
gs-1912	167	18	monolayers	monolayer	NOUN
gs-1912	167	19	of	of	ADP
gs-1912	167	20	intestinal	intestinal	ADJ
gs-1912	167	21	epithelial	epithelial	ADJ
gs-1912	167	22	(	(	PUNCT
gs-1912	167	23	caco-2	caco-2	NOUN
gs-1912	167	24	)	)	PUNCT
gs-1912	167	25	cells	cell	NOUN
gs-1912	167	26	.	.	PUNCT
gs-1912	168	1	j	j	PROPN
gs-1912	168	2	pharm	pharm	PROPN
gs-1912	168	3	sci	sci	PROPN
gs-1912	168	4	.	.	PUNCT
gs-1912	169	1	1990;79(7):595	1990;79(7):595	NUM
gs-1912	169	2	-	-	SYM
gs-1912	169	3	600	600	NUM
gs-1912	169	4	.	.	NOUN
gs-1912	170	1	15	15	NUM
gs-1912	170	2	.	.	X
gs-1912	170	3	tsiklauri	tsiklauri	PROPN
gs-1912	170	4	,	,	PUNCT
gs-1912	170	5	l.	l.	PROPN
gs-1912	170	6	k.	k.	PROPN
gs-1912	170	7	,	,	PUNCT
gs-1912	170	8	hoyer	hoyer	PROPN
gs-1912	170	9	,	,	PUNCT
gs-1912	170	10	h.	h.	PROPN
gs-1912	170	11	,	,	PUNCT
gs-1912	170	12	chkhikvadze	chkhikvadze	PROPN
gs-1912	170	13	,	,	PUNCT
gs-1912	170	14	g.	g.	PROPN
gs-1912	170	15	v.	v.	PROPN
gs-1912	170	16	,	,	PUNCT
gs-1912	170	17	vachnadze	vachnadze	NOUN
gs-1912	170	18	,	,	PUNCT
gs-1912	170	19	v.	v.	PROPN
gs-1912	170	20	y.	y.	PROPN
gs-1912	170	21	,	,	PUNCT
gs-1912	170	22	tsagareishvili	tsagareishvili	NOUN
gs-1912	170	23	,	,	PUNCT
gs-1912	170	24	g.	g.	PROPN
gs-1912	170	25	v.	v.	PROPN
gs-1912	170	26	,	,	PUNCT
gs-1912	170	27	bakuridze	bakuridze	PROPN
gs-1912	170	28	,	,	PUNCT
gs-1912	170	29	a.	a.	NOUN
gs-1912	170	30	g.	g.	PROPN
gs-1912	170	31	,	,	PUNCT
gs-1912	170	32	&	&	CCONJ
gs-1912	170	33	bernkop	bernkop	NOUN
gs-1912	170	34	-	-	PUNCT
gs-1912	170	35	schnurch	schnurch	NOUN
gs-1912	170	36	,	,	PUNCT
gs-1912	170	37	a.	a.	NOUN
gs-1912	170	38	role	role	NOUN
gs-1912	170	39	of	of	ADP
gs-1912	170	40	p	p	NOUN
gs-1912	170	41	-	-	PUNCT
gs-1912	170	42	glycoproteins	glycoprotein	NOUN
gs-1912	170	43	in	in	ADP
gs-1912	170	44	the	the	DET
gs-1912	170	45	transepithelial	transepithelial	ADJ
gs-1912	170	46	transport	transport	NOUN
gs-1912	170	47	of	of	ADP
gs-1912	170	48	indoline	indoline	NOUN
gs-1912	170	49	alkaloids	alkaloid	NOUN
gs-1912	170	50	isolated	isolate	VERB
gs-1912	170	51	from	from	ADP
gs-1912	170	52	vinca	vinca	ADJ
gs-1912	170	53	herbaceae	herbaceae	PROPN
gs-1912	170	54	.	.	PUNCT
gs-1912	171	1	pharmaceutical	pharmaceutical	ADJ
gs-1912	171	2	chemistry	chemistry	NOUN
gs-1912	171	3	journal	journal	NOUN
gs-1912	171	4	.	.	PUNCT
gs-1912	171	5	2008	2008	NUM
gs-1912	171	6	;	;	PUNCT
gs-1912	171	7	42(12):693–695	42(12):693–695	NUM
gs-1912	171	8	.	.	PUNCT
gs-1912	172	1	16	16	NUM
gs-1912	172	2	.	.	PUNCT
gs-1912	173	1	ognyanov	ognyanov	PROPN
gs-1912	173	2	i	i	PRON
gs-1912	173	3	,	,	PUNCT
gs-1912	173	4	dalev	dalev	PROPN
gs-1912	173	5	p.	p.	PROPN
gs-1912	173	6	,	,	PUNCT
gs-1912	173	7	dutschevska	dutschevska	PROPN
gs-1912	173	8	h.	h.	PROPN
gs-1912	173	9	,	,	PUNCT
gs-1912	173	10	mollov	mollov	PROPN
gs-1912	173	11	m.	m.	NOUN
gs-1912	173	12	neue	neue	PROPN
gs-1912	173	13	alkaloids	alkaloid	NOUN
gs-1912	173	14	aus	aus	PROPN
gs-1912	173	15	vinca	vinca	PROPN
gs-1912	173	16	herbacea	herbacea	PROPN
gs-1912	173	17	w.	w.	PROPN
gs-1912	173	18	et	et	PROPN
gs-1912	173	19	kit	kit	PROPN
gs-1912	173	20	.	.	PUNCT
gs-1912	174	1	c.r	c.r	PROPN
gs-1912	174	2	.	.	PROPN
gs-1912	174	3	acad	acad	PROPN
gs-1912	174	4	.	.	PUNCT
gs-1912	175	1	bulg	bulg	PROPN
gs-1912	175	2	.	.	PUNCT
gs-1912	176	1	sci	sci	PROPN
gs-1912	176	2	.	.	PROPN
gs-1912	176	3	1964	1964	NUM
gs-1912	176	4	;	;	PUNCT
gs-1912	176	5	17	17	NUM
gs-1912	176	6	:	:	SYM
gs-1912	176	7	153	153	NUM
gs-1912	176	8	-	-	SYM
gs-1912	176	9	156	156	NUM
gs-1912	176	10	.	.	PUNCT
gs-1912	176	11	17	17	NUM
gs-1912	176	12	.	.	PUNCT
gs-1912	176	13	sattler	sattler	PROPN
gs-1912	176	14	s.	s.	PROPN
gs-1912	176	15	,	,	PUNCT
gs-1912	176	16	schäfer	schäfer	PROPN
gs-1912	176	17	u.	u.	PROPN
gs-1912	176	18	,	,	PUNCT
gs-1912	176	19	schneider	schneider	PROPN
gs-1912	176	20	w.	w.	PROPN
gs-1912	176	21	,	,	PUNCT
gs-1912	176	22	hölzl	hölzl	PROPN
gs-1912	176	23	j.	j.	PROPN
gs-1912	176	24	,	,	PUNCT
gs-1912	176	25	lehr	lehr	PROPN
gs-1912	176	26	c.	c.	NOUN
gs-1912	176	27	binding	bind	VERB
gs-1912	176	28	uptake	uptake	NOUN
gs-1912	176	29	and	and	CCONJ
gs-1912	176	30	transport	transport	NOUN
gs-1912	176	31	of	of	ADP
gs-1912	176	32	hypericin	hypericin	NOUN
gs-1912	176	33	by	by	ADP
gs-1912	176	34	caco-2	caco-2	NUM
gs-1912	176	35	monolayers	monolayer	NOUN
gs-1912	176	36	.	.	PUNCT
gs-1912	177	1	j.	j.	PROPN
gs-1912	177	2	pharm	pharm	PROPN
gs-1912	177	3	.	.	PUNCT
gs-1912	178	1	sci	sci	PROPN
gs-1912	178	2	.	.	PROPN
gs-1912	178	3	1997	1997	NUM
gs-1912	178	4	;	;	PUNCT
gs-1912	178	5	86(10	86(10	NUM
gs-1912	178	6	):	):	PUNCT
gs-1912	178	7	1120	1120	NUM
gs-1912	178	8	-	-	SYM
gs-1912	178	9	1126	1126	NUM
gs-1912	178	10	.	.	PUNCT
gs-1912	179	1	georgian	georgian	ADJ
gs-1912	179	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-1912	179	3	მეცნიერები	მეცნიერები	NOUN
gs-1912	179	4	ტ.	ტ.	VERB
gs-1912	179	5	5	5	NUM
gs-1912	179	6	n	n	DET
gs-1912	179	7	2	2	NUM
gs-1912	179	8	,	,	PUNCT
gs-1912	179	9	2023	2023	NUM
gs-1912	179	10	228	228	NUM
gs-1912	179	11	18	18	NUM
gs-1912	179	12	.	.	PUNCT
gs-1912	180	1	zhou	zhou	PROPN
gs-1912	180	2	h.	h.	PROPN
gs-1912	180	3	,	,	PUNCT
gs-1912	180	4	tai	tai	PROPN
gs-1912	180	5	y.	y.	PROPN
gs-1912	180	6	,	,	PUNCT
gs-1912	180	7	sun	sun	PROPN
gs-1912	180	8	c.	c.	PROPN
gs-1912	180	9	,	,	PUNCT
gs-1912	180	10	pan	pan	PROPN
gs-1912	180	11	y.	y.	PROPN
gs-1912	180	12	rapid	rapid	ADJ
gs-1912	180	13	identification	identification	NOUN
gs-1912	180	14	of	of	ADP
gs-1912	180	15	vinca	vinca	ADJ
gs-1912	180	16	alkaloids	alkaloid	NOUN
gs-1912	180	17	by	by	ADP
gs-1912	180	18	direct	direct	ADJ
gs-1912	180	19	-	-	PUNCT
gs-1912	180	20	injection	injection	NOUN
gs-1912	180	21	electrospray	electrospray	NOUN
gs-1912	180	22	ionisation	ionisation	NOUN
gs-1912	180	23	tandem	tandem	NOUN
gs-1912	180	24	mass	mass	ADJ
gs-1912	180	25	spectrometry	spectrometry	NOUN
gs-1912	180	26	and	and	CCONJ
gs-1912	180	27	confirmation	confirmation	NOUN
gs-1912	180	28	by	by	ADP
gs-1912	180	29	high	high	ADJ
gs-1912	180	30	-	-	PUNCT
gs-1912	180	31	performance	performance	NOUN
gs-1912	180	32	liquid	liquid	ADJ
gs-1912	180	33	chromatography	chromatography	NOUN
gs-1912	180	34	-	-	PUNCT
gs-1912	180	35	mass	mass	NOUN
gs-1912	180	36	spectrometry	spectrometry	NOUN
gs-1912	180	37	.	.	PUNCT
gs-1912	181	1	pytochem	pytochem	PROPN
gs-1912	181	2	anal	anal	PROPN
gs-1912	181	3	.	.	PUNCT
gs-1912	182	1	2005;16:328	2005;16:328	NOUN
gs-1912	182	2	-	-	SYM
gs-1912	182	3	333	333	NUM
gs-1912	182	4	.	.	PUNCT
gs-1912	183	1	19	19	NUM
gs-1912	183	2	.	.	PUNCT
gs-1912	183	3	gottesman	gottesman	PROPN
gs-1912	183	4	mm	mm	PROPN
gs-1912	183	5	,	,	PUNCT
gs-1912	183	6	pastan	pastan	PROPN
gs-1912	183	7	i.	i.	NOUN
gs-1912	183	8	biochemistry	biochemistry	NOUN
gs-1912	183	9	of	of	ADP
gs-1912	183	10	multidrug	multidrug	NOUN
gs-1912	183	11	resistance	resistance	NOUN
gs-1912	183	12	mediated	mediate	VERB
gs-1912	183	13	by	by	ADP
gs-1912	183	14	the	the	DET
gs-1912	183	15	multidrug	multidrug	NOUN
gs-1912	183	16	transporter	transporter	NOUN
gs-1912	183	17	.	.	PUNCT
gs-1912	184	1	annu	annu	PROPN
gs-1912	184	2	rev	rev	VERB
gs-1912	184	3	biochem	biochem	PROPN
gs-1912	184	4	.	.	PUNCT
gs-1912	185	1	1993	1993	NUM
gs-1912	185	2	;	;	PUNCT
gs-1912	185	3	62:385	62:385	NUM
gs-1912	185	4	-	-	SYM
gs-1912	185	5	427	427	NUM
gs-1912	185	6	.	.	PUNCT
gs-1912	186	1	ვინკას	ვინკას	VERB
gs-1912	186	2	ალკალოიდების	ალკალოიდების	ADJ
gs-1912	186	3	caco-2	caco-2	NUM
gs-1912	186	4	უჯრედებში	უჯრედებში	NOUN
gs-1912	186	5	შეღწევადობა	შეღწევადობა	ADJ
gs-1912	186	6	და	და	PROPN
gs-1912	186	7	ემანაცია	ემანაცია	PROPN
gs-1912	186	8	ლია	ლია	VERB
gs-1912	186	9	წიკლაური¹	წიკლაური¹	PROPN
gs-1912	186	10	*	*	ADJ
gs-1912	186	11	,	,	PUNCT
gs-1912	186	12	ვალენტინა	ვალენტინა	ADJ
gs-1912	186	13	ვაჩნაძე¹	ვაჩნაძე¹	PROPN
gs-1912	186	14	,	,	PUNCT
gs-1912	186	15	ანდრეას	ანდრეას	PROPN
gs-1912	186	16	ბერნკოპ-შნურხი²	ბერნკოპ-შნურხი²	ADV
gs-1912	186	17	¹ი.	¹ი.	PROPN
gs-1912	186	18	ქუთათელაძის	ქუთათელაძის	ADJ
gs-1912	186	19	ფარმაკოქიმიის	ფარმაკოქიმიის	NOUN
gs-1912	186	20	ინსტიტუტი	ინსტიტუტი	NOUN
gs-1912	186	21	,	,	PUNCT
gs-1912	186	22	თსსუ	თსსუ	NOUN
gs-1912	186	23	,	,	PUNCT
gs-1912	186	24	თბილისი	თბილისი	PROPN
gs-1912	186	25	,	,	PUNCT
gs-1912	186	26	საქართველო.	საქართველო.	PROPN
gs-1912	186	27	²ფარმაციის	²ფარმაციის	PROPN
gs-1912	186	28	ინსტიტუტი	ინსტიტუტი	NOUN
gs-1912	186	29	,	,	PUNCT
gs-1912	186	30	ინსბრუკის	ინსბრუკის	NOUN
gs-1912	186	31	უნივერსიტეტი	უნივერსიტეტი	NOUN
gs-1912	186	32	,	,	PUNCT
gs-1912	186	33	ინსბრუკი	ინსბრუკი	NOUN
gs-1912	186	34	,	,	PUNCT
gs-1912	186	35	ავსტრია	ავსტრია	NUM
gs-1912	186	36	აბსტრაქტი	აბსტრაქტი	NOUN
gs-1912	186	37	ვინკას	ვინკას	PROPN
gs-1912	186	38	ალკალოიდები	ალკალოიდები	PROPN
gs-1912	186	39	ფართოდ	ფართოდ	NOUN
gs-1912	186	40	გამოიყენება	გამოიყენება	PROPN
gs-1912	186	41	სხვადასხვა	სხვადასხვა	PROPN
gs-1912	186	42	დაავადებების	დაავადებების	VERB
gs-1912	186	43	სამკურნალოდ	სამკურნალოდ	NOUN
gs-1912	186	44	;	;	PUNCT
gs-1912	187	1	მიუხედავად	მიუხედავად	PROPN
gs-1912	187	2	მათი	მათი	PROPN
gs-1912	187	3	თერაპიული	თერაპიული	PROPN
gs-1912	187	4	ეფექტურობისა	ეფექტურობისა	VERB
gs-1912	187	5	და	და	PROPN
gs-1912	187	6	მაღალი	მაღალი	PROPN
gs-1912	187	7	ფარმაკოლოგიური	ფარმაკოლოგიური	PROPN
gs-1912	187	8	აქტიურობისა	აქტიურობისა	VERB
gs-1912	187	9	,	,	PUNCT
gs-1912	187	10	p-გლიკოპროტეინის	p-გლიკოპროტეინის	NOUN
gs-1912	187	11	(	(	PUNCT
gs-1912	187	12	p	p	NOUN
gs-1912	187	13	-	-	PUNCT
gs-1912	187	14	gp	gp	NOUN
gs-1912	187	15	)	)	PUNCT
gs-1912	187	16	ჭარბ	ჭარბ	PROPN
gs-1912	187	17	ექსპრესიასთან	ექსპრესიასთან	PROPN
gs-1912	187	18	დაკავშირებული	დაკავშირებული	VERB
gs-1912	187	19	ფარმაკორეზისტენტობა	ფარმაკორეზისტენტობა	ADJ
gs-1912	187	20	რჩება	რჩება	NOUN
gs-1912	187	21	სერიოზულ	სერიოზულ	NOUN
gs-1912	187	22	კლინიკურ	კლინიკურ	ADJ
gs-1912	187	23	პრობლემად.	პრობლემად.	PROPN
gs-1912	187	24	ანტიარითმული	ანტიარითმული	PROPN
gs-1912	187	25	ალკალოიდების	ალკალოიდების	PROPN
gs-1912	187	26	ჯამის	ჯამის	PROPN
gs-1912	187	27	(	(	PUNCT
gs-1912	187	28	ვინგერბინი	ვინგერბინი	NOUN
gs-1912	187	29	)	)	PUNCT
gs-1912	187	30	ნაწლავში	ნაწლავში	NOUN
gs-1912	187	31	ბიოშეღწევადობაზე	ბიოშეღწევადობაზე	AUX
gs-1912	187	32	p	p	X
gs-1912	187	33	-	-	PUNCT
gs-1912	187	34	gpის	gpის	NOUN
gs-1912	187	35	შესაძლო	შესაძლო	NOUN
gs-1912	187	36	როლის	როლის	PROPN
gs-1912	187	37	დასადგენად	დასადგენად	NOUN
gs-1912	187	38	კვლევები	კვლევები	VERB
gs-1912	187	39	ჩატარდა	ჩატარდა	PROPN
gs-1912	187	40	ადენოკარცინომულ	ადენოკარცინომულ	PROPN
gs-1912	187	41	ურედებზე	ურედებზე	PROPN
gs-1912	187	42	(	(	PUNCT
gs-1912	187	43	caco2	caco2	NOUN
gs-1912	187	44	)	)	PUNCT
gs-1912	187	45	,	,	PUNCT
gs-1912	187	46	როგორც	როგორც	PROPN
gs-1912	187	47	ნაწლავის	ნაწლავის	PROPN
gs-1912	187	48	ბარიერის	ბარიერის	X
gs-1912	187	49	მოდელზე.	მოდელზე.	PROPN
gs-1912	188	1	ვინგერბინი	ვინგერბინი	PROPN
gs-1912	188	2	გამოყოფილია	გამოყოფილია	VERB
gs-1912	188	3	საქართველოში	საქართველოში	PROPN
gs-1912	188	4	მოზარდი	მოზარდი	PROPN
gs-1912	188	5	გველის	გველის	PROPN
gs-1912	188	6	სუროდან	სუროდან	PROPN
gs-1912	188	7	(	(	PUNCT
gs-1912	188	8	vinca	vinca	NOUN
gs-1912	188	9	herbaceae	herbaceae	NOUN
gs-1912	188	10	)	)	PUNCT
gs-1912	188	11	და	და	PROPN
gs-1912	188	12	აიმალინის	აიმალინის	PROPN
gs-1912	188	13	წარმოებული	წარმოებული	PROPN
gs-1912	188	14	ოთხი	ოთხი	PROPN
gs-1912	188	15	ალკალოიდის	ალკალოიდის	PROPN
gs-1912	188	16	(	(	PUNCT
gs-1912	188	17	ვინკარინი	ვინკარინი	PROPN
gs-1912	188	18	,	,	PUNCT
gs-1912	188	19	ჰერბადინი	ჰერბადინი	NOUN
gs-1912	188	20	,	,	PUNCT
gs-1912	188	21	ჰერბამინი	ჰერბამინი	NOUN
gs-1912	188	22	,	,	PUNCT
gs-1912	188	23	ვინკამაინი	ვინკამაინი	NOUN
gs-1912	188	24	)	)	PUNCT
gs-1912	188	25	ჯამური	ჯამური	PROPN
gs-1912	188	26	პრეპარატს	პრეპარატს	PROPN
gs-1912	188	27	წარმოადგენს.	წარმოადგენს.	PROPN
gs-1912	188	28	ალაკლოიდების	ალაკლოიდების	PROPN
gs-1912	188	29	რაოდენობრივი	რაოდენობრივი	PROPN
gs-1912	188	30	ანალიზი	ანალიზი	NOUN
gs-1912	188	31	ჩატარდა	ჩატარდა	PROPN
gs-1912	188	32	მაღალეფექტური	მაღალეფექტური	PROPN
gs-1912	188	33	სითხური	სითხური	PROPN
gs-1912	188	34	ქრომატოგრაფირიით	ქრომატოგრაფირიით	NOUN
gs-1912	188	35	(	(	PUNCT
gs-1912	188	36	hplc	hplc	PROPN
gs-1912	188	37	)	)	PUNCT
gs-1912	188	38	.	.	PUNCT
gs-1912	189	1	განისაზღვრა	განისაზღვრა	PROPN
gs-1912	189	2	ტრანსპორტირების	ტრანსპორტირების	PROPN
gs-1912	189	3	პარამეტრები	პარამეტრები	PROPN
gs-1912	189	4	,	,	PUNCT
gs-1912	189	5	ბიოშეღწევადობის	ბიოშეღწევადობის	ADJ
gs-1912	189	6	კოეფიციენტები	კოეფიციენტები	NOUN
gs-1912	189	7	და	და	NOUN
gs-1912	189	8	ტრანსპორტირების	ტრანსპორტირების	ADJ
gs-1912	189	9	პროცენტი.	პროცენტი.	ADJ
gs-1912	189	10	ვინკარინი	ვინკარინი	NOUN
gs-1912	189	11	და	და	PROPN
gs-1912	189	12	ჰერბადინი	ჰერბადინი	PROPN
gs-1912	189	13	ტრანსცელულარული	ტრანსცელულარული	PROPN
gs-1912	189	14	გამოდევნის	გამოდევნის	PROPN
gs-1912	189	15	მაღალი	მაღალი	PROPN
gs-1912	189	16	მაჩვენებლებით	მაჩვენებლებით	PROPN
gs-1912	189	17	გამოირჩეოდნენ	გამოირჩეოდნენ	NOUN
gs-1912	189	18	;	;	PUNCT
gs-1912	189	19	ვერაპამილის	ვერაპამილის	PROPN
gs-1912	189	20	თანაარსებობისას	თანაარსებობისას	PROPN
gs-1912	189	21	,	,	PUNCT
gs-1912	189	22	ალკალოიდების	ალკალოიდების	ADJ
gs-1912	189	23	აპიკალური	აპიკალური	PROPN
gs-1912	189	24	ტრანსპორტი	ტრანსპორტი	PROPN
gs-1912	189	25	გაიზარდა	გაიზარდა	NOUN
gs-1912	189	26	,	,	PUNCT
gs-1912	189	27	ხოლო	ხოლო	NOUN
gs-1912	189	28	ბაზოლატერული	ბაზოლატერული	NOUN
gs-1912	189	29	შემცირდა.	შემცირდა.	NOUN
gs-1912	189	30	ჰერბამინისა	ჰერბამინისა	AUX
gs-1912	189	31	და	და	VERB
gs-1912	189	32	ვინკამაინის	ვინკამაინის	PROPN
gs-1912	189	33	შემთხვევაში	შემთხვევაში	PROPN
gs-1912	189	34	მემბრანაში	მემბრანაში	NOUN
gs-1912	189	35	ასიმეტრიული	ასიმეტრიული	PROPN
gs-1912	189	36	გამტარობა	გამტარობა	PROPN
gs-1912	189	37	არ	არ	PROPN
gs-1912	189	38	დაფიქსირებულა.	დაფიქსირებულა.	PROPN
gs-1912	189	39	მიღებული	მიღებული	PROPN
gs-1912	189	40	შედეგებით	შედეგებით	PROPN
gs-1912	189	41	ვინკარინისა	ვინკარინისა	ADP
gs-1912	189	42	და	და	PROPN
gs-1912	189	43	ჰერბადინისთვის	ჰერბადინისთვის	NOUN
gs-1912	189	44	დამახასიათებელია	დამახასიათებელია	VERB
gs-1912	189	45	p	p	NOUN
gs-1912	189	46	-	-	PUNCT
gs-1912	189	47	gp	gp	NOUN
gs-1912	189	48	-ით	-ით	PUNCT
gs-1912	189	49	განპირობებული	განპირობებული	PROPN
gs-1912	189	50	ტიპიური	ტიპიური	PROPN
gs-1912	189	51	ტრანსპორტირების	ტრანსპორტირების	PROPN
gs-1912	189	52	თვისებები	თვისებები	NOUN
gs-1912	189	53	,	,	PUNCT
gs-1912	189	54	მათ	მათ	NUM
gs-1912	189	55	შორის	შორის	NOUN
gs-1912	189	56	პრეფერენციული	პრეფერენციული	VERB
gs-1912	189	57	ტრანსპორტი	ტრანსპორტი	PROPN
gs-1912	189	58	ბაზოლატერულიდან	ბაზოლატერულიდან	PROPN
gs-1912	189	59	აპიკალური	აპიკალური	PROPN
gs-1912	189	60	მიმართულებით.	მიმართულებით.	NOUN
gs-1912	189	61	ვინგერბინის	ვინგერბინის	PROPN
gs-1912	189	62	ტრანსპორტირებაში	ტრანსპორტირებაში	VERB
gs-1912	189	63	ppg-ის	ppg-ის	PROPN
gs-1912	189	64	ჩართულობის	ჩართულობის	PROPN
gs-1912	189	65	გამო	გამო	VERB
gs-1912	189	66	ანტიარითმული	ანტიარითმული	PROPN
gs-1912	189	67	ალკალოიდების	ალკალოიდების	ADJ
gs-1912	189	68	ნაწლავური	ნაწლავური	PROPN
gs-1912	189	69	შეღწევადობის	შეღწევადობის	NOUN
gs-1912	189	70	გასაუმჯობესებლად	გასაუმჯობესებლად	NOUN
gs-1912	189	71	შემდგომი	შემდგომი	NOUN
gs-1912	189	72	კვლევები	კვლევები	VERB
gs-1912	189	73	ფოკუსირდება	ფოკუსირდება	PROPN
gs-1912	189	74	ნანომედიცინაზე	ნანომედიცინაზე	PROPN
gs-1912	189	75	დაფუძნებული	დაფუძნებული	PROPN
gs-1912	189	76	შესაბამისი	შესაბამისი	PROPN
gs-1912	189	77	სტრატეგიების	სტრატეგიების	PROPN
gs-1912	189	78	სკრინინგზე.	სკრინინგზე.	PROPN
gs-1912	189	79	საკვანძო	საკვანძო	PROPN
gs-1912	189	80	სიტყვები	სიტყვები	NOUN
gs-1912	189	81	:	:	PUNCT
gs-1912	189	82	ვინკას	ვინკას	NOUN
gs-1912	189	83	ალკალოიდები	ალკალოიდები	NOUN
gs-1912	189	84	,	,	PUNCT
gs-1912	189	85	ვინგერბინი	ვინგერბინი	NOUN
gs-1912	189	86	,	,	PUNCT
gs-1912	189	87	caco-2	caco-2	NOUN
gs-1912	189	88	,	,	PUNCT
gs-1912	189	89	p-გლიკოპროტეინი	p-გლიკოპროტეინი	NOUN
gs-1912	189	90	(	(	PUNCT
gs-1912	189	91	p	p	NOUN
gs-1912	189	92	-	-	PUNCT
gs-1912	189	93	gp	gp	NOUN
gs-1912	189	94	)	)	PUNCT
gs-1912	189	95	.	.	PUNCT