id	sid	tid	token	lemma	pos
gs-2738	1	1	microsoft	microsoft	PROPN
gs-2738	1	2	word	word	NOUN
gs-2738	1	3	fullpdf06012024	fullpdf06012024	VERB
gs-2738	1	4	georgian	georgian	ADJ
gs-2738	1	5	scientists/ქართველი	scientists/ქართველი	NOUN
gs-2738	1	6	მეცნიერები	მეცნიერები	NOUN
gs-2738	1	7	ტ.	ტ.	VERB
gs-2738	1	8	6	6	NUM
gs-2738	1	9	n	n	NUM
gs-2738	1	10	1	1	NUM
gs-2738	1	11	,	,	PUNCT
gs-2738	1	12	2024	2024	NUM
gs-2738	1	13	289	289	NUM
gs-2738	1	14	georgian	georgian	PROPN
gs-2738	1	15	scientists	scientist	NOUN
gs-2738	1	16	ქართველი	ქართველი	ADJ
gs-2738	1	17	მეცნიერები	მეცნიერები	PROPN
gs-2738	1	18	vol	vol	NOUN
gs-2738	1	19	.	.	PROPN
gs-2738	2	1	6	6	NUM
gs-2738	2	2	issue	issue	NOUN
gs-2738	2	3	1	1	NUM
gs-2738	2	4	,	,	PUNCT
gs-2738	2	5	2024	2024	NUM
gs-2738	2	6	https://doi.org/10.52340/gs.2024.06.01.35	https://doi.org/10.52340/gs.2024.06.01.35	NOUN
gs-2738	2	7	prostaglandin	prostaglandin	NOUN
gs-2738	2	8	e2	e2	NOUN
gs-2738	2	9	as	as	ADP
gs-2738	2	10	neuroinflammatory	neuroinflammatory	ADJ
gs-2738	2	11	target	target	NOUN
gs-2738	2	12	in	in	ADP
gs-2738	2	13	childhood	childhood	NOUN
gs-2738	2	14	resistant	resistant	ADJ
gs-2738	2	15	epilepsies	epilepsy	NOUN
gs-2738	2	16	.	.	PUNCT
gs-2738	3	1	tatia	tatia	PRON
gs-2738	3	2	gakharia	gakharia	PROPN
gs-2738	3	3	1	1	NUM
gs-2738	3	4	*	*	PROPN
gs-2738	3	5	,	,	PUNCT
gs-2738	3	6	sophia	sophia	PROPN
gs-2738	3	7	bakhtadze	bakhtadze	PROPN
gs-2738	3	8	1	1	NUM
gs-2738	3	9	,	,	PUNCT
gs-2738	3	10	nana	nana	PROPN
gs-2738	3	11	khachapuridze	khachapuridze	PROPN
gs-2738	3	12	1	1	NUM
gs-2738	3	13	and	and	CCONJ
gs-2738	3	14	nana	nana	PROPN
gs-2738	3	15	kapanadze1	kapanadze1	PROPN
gs-2738	4	1	1department	1department	NUM
gs-2738	4	2	of	of	ADP
gs-2738	4	3	childs	childs	PROPN
gs-2738	4	4	neurology	neurology	PROPN
gs-2738	4	5	,	,	PUNCT
gs-2738	4	6	tbilisi	tbilisi	PROPN
gs-2738	4	7	state	state	PROPN
gs-2738	4	8	medical	medical	PROPN
gs-2738	4	9	university	university	PROPN
gs-2738	4	10	,	,	PUNCT
gs-2738	4	11	0186	0186	NUM
gs-2738	4	12	tbilisi	tbilisi	PROPN
gs-2738	4	13	,	,	PUNCT
gs-2738	4	14	georgia	georgia	PROPN
gs-2738	4	15	*	*	SYM
gs-2738	4	16	correspondence	correspondence	NOUN
gs-2738	4	17	:	:	PUNCT
gs-2738	4	18	tatia	tatia	PROPN
gs-2738	4	19	gakharia	gakharia	PROPN
gs-2738	4	20	,	,	PUNCT
gs-2738	4	21	tbilisi	tbilisi	PROPN
gs-2738	4	22	state	state	PROPN
gs-2738	4	23	medical	medical	PROPN
gs-2738	4	24	university	university	PROPN
gs-2738	4	25	orcid	orcid	NOUN
gs-2738	4	26	:	:	PUNCT
gs-2738	4	27	0000	0000	NUM
gs-2738	4	28	-	-	PUNCT
gs-2738	4	29	0002	0002	NUM
gs-2738	4	30	-	-	PUNCT
gs-2738	4	31	3709	3709	NUM
gs-2738	4	32	-	-	PUNCT
gs-2738	4	33	4069	4069	NUM
gs-2738	4	34	abstract	abstract	ADJ
gs-2738	4	35	aim	aim	NOUN
gs-2738	4	36	:	:	PUNCT
gs-2738	4	37	childhood	childhood	NOUN
gs-2738	4	38	epilepsies	epilepsy	NOUN
gs-2738	4	39	are	be	AUX
gs-2738	4	40	a	a	DET
gs-2738	4	41	diverse	diverse	ADJ
gs-2738	4	42	group	group	NOUN
gs-2738	4	43	of	of	ADP
gs-2738	4	44	neurological	neurological	ADJ
gs-2738	4	45	disorders	disorder	NOUN
gs-2738	4	46	with	with	ADP
gs-2738	4	47	a	a	DET
gs-2738	4	48	multifaceted	multifaceted	ADJ
gs-2738	4	49	clinical	clinical	ADJ
gs-2738	4	50	course	course	NOUN
gs-2738	4	51	caused	cause	VERB
gs-2738	4	52	by	by	ADP
gs-2738	4	53	a	a	DET
gs-2738	4	54	range	range	NOUN
gs-2738	4	55	of	of	ADP
gs-2738	4	56	aetiological	aetiological	ADJ
gs-2738	4	57	factors	factor	NOUN
gs-2738	4	58	.	.	PUNCT
gs-2738	5	1	despite	despite	SCONJ
gs-2738	5	2	new	new	ADJ
gs-2738	5	3	anti	anti	NOUN
gs-2738	5	4	seizure	seizure	NOUN
gs-2738	5	5	drugs	drug	NOUN
gs-2738	5	6	(	(	PUNCT
gs-2738	5	7	asds	asds	NOUN
gs-2738	5	8	)	)	PUNCT
gs-2738	5	9	,	,	PUNCT
gs-2738	5	10	drug	drug	NOUN
gs-2738	5	11	resistance	resistance	NOUN
gs-2738	5	12	remains	remain	VERB
gs-2738	5	13	a	a	DET
gs-2738	5	14	significant	significant	ADJ
gs-2738	5	15	hurdle	hurdle	NOUN
gs-2738	5	16	in	in	ADP
gs-2738	5	17	treatment	treatment	NOUN
gs-2738	5	18	.	.	PUNCT
gs-2738	6	1	growing	grow	VERB
gs-2738	6	2	evidence	evidence	NOUN
gs-2738	6	3	links	link	NOUN
gs-2738	6	4	epilepsy	epilepsy	VERB
gs-2738	6	5	to	to	ADP
gs-2738	6	6	inflammatory	inflammatory	ADJ
gs-2738	6	7	processes	process	NOUN
gs-2738	6	8	,	,	PUNCT
gs-2738	6	9	especially	especially	ADV
gs-2738	6	10	in	in	ADP
gs-2738	6	11	drug	drug	NOUN
gs-2738	6	12	-	-	PUNCT
gs-2738	6	13	resistant	resistant	ADJ
gs-2738	6	14	cases	case	NOUN
gs-2738	6	15	.	.	PUNCT
gs-2738	7	1	a	a	DET
gs-2738	7	2	number	number	NOUN
gs-2738	7	3	of	of	ADP
gs-2738	7	4	neuroinflammatory	neuroinflammatory	ADJ
gs-2738	7	5	pathways	pathway	NOUN
gs-2738	7	6	involving	involve	VERB
gs-2738	7	7	cytokines	cytokine	NOUN
gs-2738	7	8	have	have	AUX
gs-2738	7	9	been	be	AUX
gs-2738	7	10	identified	identify	VERB
gs-2738	7	11	in	in	ADP
gs-2738	7	12	the	the	DET
gs-2738	7	13	pathogenesis	pathogenesis	NOUN
gs-2738	7	14	of	of	ADP
gs-2738	7	15	drug	drug	NOUN
gs-2738	7	16	resistant	resistant	ADJ
gs-2738	7	17	epilepsy	epilepsy	NOUN
gs-2738	7	18	,	,	PUNCT
gs-2738	7	19	including	include	VERB
gs-2738	7	20	the	the	DET
gs-2738	7	21	axis	axis	NOUN
gs-2738	7	22	of	of	ADP
gs-2738	7	23	cox2	cox2	NOUN
gs-2738	7	24	–	–	PUNCT
gs-2738	7	25	pge2prostaglandin	pge2prostaglandin	VERB
gs-2738	7	26	e2	e2	NOUN
gs-2738	7	27	receptor	receptor	NOUN
gs-2738	7	28	1	1	NUM
gs-2738	7	29	that	that	PRON
gs-2738	7	30	has	have	AUX
gs-2738	7	31	been	be	AUX
gs-2738	7	32	shown	show	VERB
gs-2738	7	33	to	to	PART
gs-2738	7	34	affect	affect	VERB
gs-2738	7	35	blood	blood	NOUN
gs-2738	7	36	-	-	PUNCT
gs-2738	7	37	brain	brain	NOUN
gs-2738	7	38	barrier	barrier	NOUN
gs-2738	7	39	function	function	NOUN
gs-2738	7	40	,	,	PUNCT
gs-2738	7	41	and	and	CCONJ
gs-2738	7	42	drug	drug	NOUN
gs-2738	7	43	pharmacokinetics	pharmacokinetic	NOUN
gs-2738	7	44	through	through	ADP
gs-2738	7	45	upregulation	upregulation	NOUN
gs-2738	7	46	of	of	ADP
gs-2738	7	47	multidrug	multidrug	NOUN
gs-2738	7	48	effluxers	effluxer	NOUN
gs-2738	7	49	.	.	PUNCT
gs-2738	8	1	we	we	PRON
gs-2738	8	2	measured	measure	VERB
gs-2738	8	3	the	the	DET
gs-2738	8	4	plasma	plasma	NOUN
gs-2738	8	5	pge2	pge2	NOUN
gs-2738	8	6	levels	level	NOUN
gs-2738	8	7	aiming	aim	VERB
gs-2738	8	8	to	to	PART
gs-2738	8	9	determine	determine	VERB
gs-2738	8	10	pge2	pge2	NOUN
gs-2738	8	11	importance	importance	NOUN
gs-2738	8	12	in	in	ADP
gs-2738	8	13	epilepsy	epilepsy	NOUN
gs-2738	8	14	-	-	PUNCT
gs-2738	8	15	associated	associate	VERB
gs-2738	8	16	inflammation	inflammation	NOUN
gs-2738	8	17	and	and	CCONJ
gs-2738	8	18	antiepileptic	antiepileptic	ADJ
gs-2738	8	19	drug	drug	NOUN
gs-2738	8	20	(	(	PUNCT
gs-2738	8	21	aed	aed	NOUN
gs-2738	8	22	)	)	PUNCT
gs-2738	8	23	response	response	NOUN
gs-2738	8	24	for	for	ADP
gs-2738	8	25	the	the	DET
gs-2738	8	26	patients	patient	NOUN
gs-2738	8	27	with	with	ADP
gs-2738	8	28	different	different	ADJ
gs-2738	8	29	types	type	NOUN
gs-2738	8	30	of	of	ADP
gs-2738	8	31	epilepsy	epilepsy	NOUN
gs-2738	8	32	.	.	PUNCT
gs-2738	9	1	methods	method	NOUN
gs-2738	9	2	:	:	PUNCT
gs-2738	9	3	a	a	DET
gs-2738	9	4	prospective	prospective	ADJ
gs-2738	9	5	review	review	NOUN
gs-2738	9	6	of	of	ADP
gs-2738	9	7	clinical	clinical	ADJ
gs-2738	9	8	and	and	CCONJ
gs-2738	9	9	paraclinical	paraclinical	ADJ
gs-2738	9	10	data	datum	NOUN
gs-2738	9	11	of	of	ADP
gs-2738	9	12	study	study	NOUN
gs-2738	9	13	group	group	NOUN
gs-2738	9	14	(	(	PUNCT
gs-2738	9	15	group	group	NOUN
gs-2738	9	16	1	1	NUM
gs-2738	9	17	)	)	PUNCT
gs-2738	9	18	,	,	PUNCT
gs-2738	9	19	including	include	VERB
gs-2738	9	20	patients	patient	NOUN
gs-2738	9	21	with	with	ADP
gs-2738	9	22	epilepsy	epilepsy	NOUN
gs-2738	9	23	who	who	PRON
gs-2738	9	24	had	have	VERB
gs-2738	9	25	ongoing	ongoing	ADJ
gs-2738	9	26	long	long	ADJ
gs-2738	9	27	term	term	NOUN
gs-2738	9	28	follow	follow	NOUN
gs-2738	9	29	-	-	PUNCT
gs-2738	9	30	up	up	NOUN
gs-2738	9	31	in	in	ADP
gs-2738	9	32	two	two	NUM
gs-2738	9	33	subgroups	subgroup	NOUN
gs-2738	9	34	:	:	PUNCT
gs-2738	9	35	group	group	NOUN
gs-2738	9	36	1a	1a	NOUN
gs-2738	9	37	-	-	PUNCT
gs-2738	9	38	patients	patient	NOUN
gs-2738	9	39	diagnosed	diagnose	VERB
gs-2738	9	40	with	with	ADP
gs-2738	9	41	epilepsy	epilepsy	ADJ
gs-2738	9	42	-seizure	-seizure	NOUN
gs-2738	9	43	-	-	PUNCT
gs-2738	9	44	free	free	ADJ
gs-2738	9	45	on	on	ADP
gs-2738	9	46	aed	aed	NOUN
gs-2738	9	47	therapy	therapy	NOUN
gs-2738	9	48	,	,	PUNCT
gs-2738	9	49	group	group	NOUN
gs-2738	9	50	1bpatients	1bpatients	NUM
gs-2738	9	51	with	with	ADP
gs-2738	9	52	refractory	refractory	NOUN
gs-2738	9	53	epilepsy	epilepsy	NOUN
gs-2738	9	54	and	and	CCONJ
gs-2738	9	55	healthy	healthy	ADJ
gs-2738	9	56	control	control	NOUN
gs-2738	9	57	group	group	NOUN
gs-2738	9	58	(	(	PUNCT
gs-2738	9	59	group2	group2	NOUN
gs-2738	9	60	)	)	PUNCT
gs-2738	9	61	.	.	PUNCT
gs-2738	10	1	serum	serum	NOUN
gs-2738	10	2	samples	sample	NOUN
gs-2738	10	3	tested	test	VERB
gs-2738	10	4	for	for	ADP
gs-2738	10	5	pge2	pge2	NOUN
gs-2738	10	6	levels(interquartile	levels(interquartile	ADJ
gs-2738	10	7	ranges	range	NOUN
gs-2738	10	8	/	/	SYM
gs-2738	10	9	pg	pg	NOUN
gs-2738	10	10	/	/	SYM
gs-2738	10	11	ml	ml	VERB
gs-2738	10	12	)	)	PUNCT
gs-2738	10	13	by	by	ADP
gs-2738	10	14	the	the	DET
gs-2738	10	15	enzyme	enzyme	NOUN
gs-2738	10	16	-	-	PUNCT
gs-2738	10	17	linked	link	VERB
gs-2738	10	18	immunosorbent	immunosorbent	NOUN
gs-2738	10	19	assay	assay	PROPN
gs-2738	10	20	(	(	PUNCT
gs-2738	10	21	elisa	elisa	NOUN
gs-2738	10	22	)	)	PUNCT
gs-2738	10	23	.	.	PUNCT
gs-2738	11	1	results	result	NOUN
gs-2738	11	2	:	:	PUNCT
gs-2738	11	3	measured	measure	VERB
gs-2738	11	4	serum	serum	NOUN
gs-2738	11	5	pge2	pge2	NOUN
gs-2738	11	6	the	the	DET
gs-2738	11	7	median	median	PROPN
gs-2738	11	8	interquartile	interquartile	NOUN
gs-2738	11	9	ranges	range	VERB
gs-2738	11	10	(	(	PUNCT
gs-2738	11	11	iqr	iqr	NOUN
gs-2738	11	12	)	)	PUNCT
gs-2738	11	13	were	be	AUX
gs-2738	11	14	higher	high	ADJ
gs-2738	11	15	and	and	CCONJ
gs-2738	11	16	in	in	ADP
gs-2738	11	17	broader	broad	ADJ
gs-2738	11	18	ranges	range	NOUN
gs-2738	11	19	for	for	ADP
gs-2738	11	20	epilepsy	epilepsy	NOUN
gs-2738	11	21	patients	patient	NOUN
gs-2738	11	22	all	all	ADV
gs-2738	11	23	together	together	ADV
gs-2738	11	24	512	512	NUM
gs-2738	11	25	pg	pg	NOUN
gs-2738	11	26	/	/	SYM
gs-2738	11	27	ml	ml	PROPN
gs-2738	11	28	(	(	PUNCT
gs-2738	11	29	324.5	324.5	NUM
gs-2738	11	30	-	-	SYM
gs-2738	11	31	970.0	970.0	NUM
gs-2738	11	32	)	)	PUNCT
gs-2738	11	33	compared	compare	VERB
gs-2738	11	34	to	to	ADP
gs-2738	11	35	healthy	healthy	ADJ
gs-2738	11	36	controls	control	NOUN
gs-2738	11	37	406	406	NUM
gs-2738	11	38	pg	pg	NOUN
gs-2738	11	39	/	/	SYM
gs-2738	11	40	ml	ml	PROPN
gs-2738	11	41	(	(	PUNCT
gs-2738	11	42	278.7	278.7	NUM
gs-2738	11	43	-	-	SYM
gs-2738	11	44	541.4	541.4	NUM
gs-2738	11	45	)	)	PUNCT
gs-2738	11	46	,	,	PUNCT
gs-2738	11	47	but	but	CCONJ
gs-2738	11	48	not	not	PART
gs-2738	11	49	significantly	significantly	ADV
gs-2738	11	50	different	different	ADJ
gs-2738	11	51	across	across	ADP
gs-2738	11	52	the	the	DET
gs-2738	11	53	epilepsy	epilepsy	NOUN
gs-2738	11	54	study	study	NOUN
gs-2738	11	55	groups	group	NOUN
gs-2738	11	56	(	(	PUNCT
gs-2738	11	57	p>0.05	p>0.05	PROPN
gs-2738	11	58	)	)	PUNCT
gs-2738	11	59	.	.	PUNCT
gs-2738	12	1	only	only	ADV
gs-2738	12	2	valproate	valproate	ADJ
gs-2738	12	3	responders	responder	NOUN
gs-2738	12	4	showed	show	VERB
gs-2738	12	5	reduced	reduced	ADJ
gs-2738	12	6	pge2	pge2	NOUN
gs-2738	12	7	mean	mean	PROPN
gs-2738	12	8	iqr	iqr	PROPN
gs-2738	12	9	490	490	NUM
gs-2738	12	10	pg	pg	NOUN
gs-2738	12	11	/	/	SYM
gs-2738	12	12	ml	ml	NOUN
gs-2738	12	13	.	.	PUNCT
gs-2738	13	1	conclusions	conclusion	NOUN
gs-2738	13	2	:	:	PUNCT
gs-2738	13	3	our	our	PRON
gs-2738	13	4	findings	finding	NOUN
gs-2738	13	5	align	align	VERB
gs-2738	13	6	with	with	ADP
gs-2738	13	7	preclinical	preclinical	ADJ
gs-2738	13	8	models	model	NOUN
gs-2738	13	9	,	,	PUNCT
gs-2738	13	10	suggesting	suggest	VERB
gs-2738	13	11	a	a	DET
gs-2738	13	12	potential	potential	ADJ
gs-2738	13	13	target	target	NOUN
gs-2738	13	14	on	on	ADP
gs-2738	13	15	molecular	molecular	ADJ
gs-2738	13	16	basis	basis	NOUN
gs-2738	13	17	for	for	ADP
gs-2738	13	18	overcoming	overcome	VERB
gs-2738	13	19	drug	drug	NOUN
gs-2738	13	20	resistance	resistance	NOUN
gs-2738	13	21	,	,	PUNCT
gs-2738	13	22	which	which	PRON
gs-2738	13	23	is	be	AUX
gs-2738	13	24	a	a	DET
gs-2738	13	25	major	major	ADJ
gs-2738	13	26	challenge	challenge	NOUN
gs-2738	13	27	and	and	CCONJ
gs-2738	13	28	key	key	NOUN
gs-2738	13	29	toward	toward	ADP
gs-2738	13	30	precision	precision	NOUN
gs-2738	13	31	medicine	medicine	NOUN
gs-2738	13	32	in	in	ADP
gs-2738	13	33	epilepsy	epilepsy	NOUN
gs-2738	13	34	management	management	NOUN
gs-2738	13	35	.	.	PUNCT
gs-2738	14	1	keywords	keyword	NOUN
gs-2738	14	2	:	:	PUNCT
gs-2738	14	3	paediatric	paediatric	ADJ
gs-2738	14	4	epilepsy	epilepsy	NOUN
gs-2738	14	5	;	;	PUNCT
gs-2738	14	6	drug	drug	NOUN
gs-2738	14	7	-	-	PUNCT
gs-2738	14	8	resistant	resistant	ADJ
gs-2738	14	9	;	;	PUNCT
gs-2738	14	10	neuroinflammation	neuroinflammation	NOUN
gs-2738	14	11	georgian	georgian	ADJ
gs-2738	14	12	scientists/ქართველი	scientists/ქართველი	NOUN
gs-2738	14	13	მეცნიერები	მეცნიერები	NOUN
gs-2738	14	14	ტ.	ტ.	VERB
gs-2738	14	15	6	6	NUM
gs-2738	14	16	n	n	NUM
gs-2738	14	17	1	1	NUM
gs-2738	14	18	,	,	PUNCT
gs-2738	14	19	2024	2024	NUM
gs-2738	14	20	290	290	NUM
gs-2738	14	21	introduction	introduction	NOUN
gs-2738	14	22	pediatric	pediatric	ADJ
gs-2738	14	23	epilepsy	epilepsy	NOUN
gs-2738	14	24	is	be	AUX
gs-2738	14	25	a	a	DET
gs-2738	14	26	multifaceted	multifaceted	ADJ
gs-2738	14	27	neurological	neurological	ADJ
gs-2738	14	28	disorder	disorder	NOUN
gs-2738	14	29	with	with	ADP
gs-2738	14	30	various	various	ADJ
gs-2738	14	31	etiology	etiology	NOUN
gs-2738	14	32	,	,	PUNCT
gs-2738	14	33	which	which	PRON
gs-2738	14	34	affects	affect	VERB
gs-2738	14	35	0.6	0.6	NUM
gs-2738	14	36	%	%	NOUN
gs-2738	14	37	of	of	ADP
gs-2738	14	38	children	child	NOUN
gs-2738	14	39	between	between	ADP
gs-2738	14	40	the	the	DET
gs-2738	14	41	ages	age	NOUN
gs-2738	14	42	of	of	ADP
gs-2738	14	43	0	0	NUM
gs-2738	14	44	and	and	CCONJ
gs-2738	14	45	17	17	NUM
gs-2738	14	46	years	year	NOUN
gs-2738	14	47	[	[	X
gs-2738	14	48	1,2	1,2	NUM
gs-2738	14	49	]	]	PUNCT
gs-2738	14	50	.	.	PUNCT
gs-2738	15	1	antiepileptic	antiepileptic	ADJ
gs-2738	15	2	drugs	drug	NOUN
gs-2738	15	3	(	(	PUNCT
gs-2738	15	4	aed	aed	NOUN
gs-2738	15	5	)	)	PUNCT
gs-2738	15	6	are	be	AUX
gs-2738	15	7	the	the	DET
gs-2738	15	8	mainstay	mainstay	NOUN
gs-2738	15	9	of	of	ADP
gs-2738	15	10	treatment	treatment	NOUN
gs-2738	15	11	for	for	ADP
gs-2738	15	12	childhood	childhood	NOUN
gs-2738	15	13	epilepsies	epilepsy	NOUN
gs-2738	15	14	,	,	PUNCT
gs-2738	15	15	90	90	NUM
gs-2738	15	16	%	%	NOUN
gs-2738	15	17	cases	case	NOUN
gs-2738	15	18	of	of	ADP
gs-2738	15	19	epilepsy	epilepsy	NOUN
gs-2738	15	20	in	in	ADP
gs-2738	15	21	childhood	childhood	NOUN
gs-2738	15	22	is	be	AUX
gs-2738	15	23	adhered	adhere	VERB
gs-2738	15	24	to	to	PART
gs-2738	15	25	recommended	recommend	VERB
gs-2738	15	26	aed	aed	NOUN
gs-2738	15	27	treatment	treatment	NOUN
gs-2738	15	28	.	.	PUNCT
gs-2738	16	1	with	with	ADP
gs-2738	16	2	each	each	DET
gs-2738	16	3	subsequent	subsequent	ADJ
gs-2738	16	4	unsuccessful	unsuccessful	ADJ
gs-2738	16	5	aed	aed	NOUN
gs-2738	16	6	regimen	regiman	NOUN
gs-2738	16	7	tries	try	VERB
gs-2738	16	8	the	the	DET
gs-2738	16	9	likelihood	likelihood	NOUN
gs-2738	16	10	of	of	ADP
gs-2738	16	11	seizure	seizure	NOUN
gs-2738	16	12	freedom	freedom	NOUN
gs-2738	16	13	decreases	decrease	VERB
gs-2738	16	14	significantly	significantly	ADV
gs-2738	16	15	.	.	PUNCT
gs-2738	17	1	adequate	adequate	ADJ
gs-2738	17	2	seizure	seizure	NOUN
gs-2738	17	3	control	control	NOUN
gs-2738	17	4	is	be	AUX
gs-2738	17	5	not	not	PART
gs-2738	17	6	achieved	achieve	VERB
gs-2738	17	7	in	in	ADP
gs-2738	17	8	30	30	NUM
gs-2738	17	9	%	%	NOUN
gs-2738	17	10	of	of	ADP
gs-2738	17	11	patients	patient	NOUN
gs-2738	17	12	,	,	PUNCT
gs-2738	17	13	especially	especially	ADV
gs-2738	17	14	in	in	ADP
gs-2738	17	15	epileptic	epileptic	ADJ
gs-2738	17	16	encephalopathies	encephalopathy	NOUN
gs-2738	17	17	which	which	PRON
gs-2738	17	18	are	be	AUX
gs-2738	17	19	considered	consider	VERB
gs-2738	17	20	drug	drug	NOUN
gs-2738	17	21	-	-	PUNCT
gs-2738	17	22	resistant	resistant	ADJ
gs-2738	17	23	[	[	X
gs-2738	17	24	3	3	NUM
gs-2738	17	25	]	]	PUNCT
gs-2738	17	26	.	.	PUNCT
gs-2738	18	1	the	the	DET
gs-2738	18	2	working	work	VERB
gs-2738	18	3	hypothesis	hypothesis	NOUN
gs-2738	18	4	on	on	ADP
gs-2738	18	5	drug	drug	NOUN
gs-2738	18	6	resistance	resistance	NOUN
gs-2738	18	7	to	to	PART
gs-2738	18	8	be	be	AUX
gs-2738	18	9	refined	refine	VERB
gs-2738	18	10	with	with	ADP
gs-2738	18	11	time	time	NOUN
gs-2738	18	12	.based	.base	VERB
gs-2738	18	13	on	on	ADP
gs-2738	18	14	ilae	ilae	NOUN
gs-2738	18	15	classification	classification	NOUN
gs-2738	18	16	2017	2017	NUM
gs-2738	18	17	drug	drug	NOUN
gs-2738	18	18	-	-	PUNCT
gs-2738	18	19	resistant	resistant	ADJ
gs-2738	18	20	or	or	CCONJ
gs-2738	18	21	refractory	refractory	NOUN
gs-2738	18	22	seizures	seizure	NOUN
gs-2738	18	23	refer	refer	VERB
gs-2738	18	24	to	to	ADP
gs-2738	18	25	“	"	PUNCT
gs-2738	18	26	failure	failure	NOUN
gs-2738	18	27	of	of	ADP
gs-2738	18	28	adequate	adequate	ADJ
gs-2738	18	29	trials	trial	NOUN
gs-2738	18	30	of	of	ADP
gs-2738	18	31	two	two	NUM
gs-2738	18	32	tolerated	tolerate	VERB
gs-2738	18	33	,	,	PUNCT
gs-2738	18	34	appropriately	appropriately	ADV
gs-2738	18	35	chosen	choose	VERB
gs-2738	18	36	and	and	CCONJ
gs-2738	18	37	used	use	VERB
gs-2738	18	38	antiepileptic	antiepileptic	ADJ
gs-2738	18	39	drug	drug	NOUN
gs-2738	18	40	schedules	schedule	NOUN
gs-2738	18	41	(	(	PUNCT
gs-2738	18	42	whether	whether	SCONJ
gs-2738	18	43	as	as	SCONJ
gs-2738	18	44	monotherapies	monotherapie	NOUN
gs-2738	18	45	or	or	CCONJ
gs-2738	18	46	in	in	ADP
gs-2738	18	47	combination	combination	NOUN
gs-2738	18	48	)	)	PUNCT
gs-2738	18	49	to	to	PART
gs-2738	18	50	achieve	achieve	VERB
gs-2738	18	51	sustained	sustained	ADJ
gs-2738	18	52	seizure	seizure	NOUN
gs-2738	18	53	freedom	freedom	NOUN
gs-2738	18	54	”	"	PUNCT
gs-2738	19	1	[	[	X
gs-2738	19	2	4	4	NUM
gs-2738	19	3	]	]	PUNCT
gs-2738	19	4	.	.	PUNCT
gs-2738	20	1	despite	despite	SCONJ
gs-2738	20	2	many	many	ADJ
gs-2738	20	3	years	year	NOUN
gs-2738	20	4	of	of	ADP
gs-2738	20	5	research	research	NOUN
gs-2738	20	6	,	,	PUNCT
gs-2738	20	7	developing	develop	VERB
gs-2738	20	8	novel	novel	ADJ
gs-2738	20	9	treatments	treatment	NOUN
gs-2738	20	10	and	and	CCONJ
gs-2738	20	11	management	management	NOUN
gs-2738	20	12	strategies	strategy	NOUN
gs-2738	20	13	for	for	ADP
gs-2738	20	14	drug	drug	NOUN
gs-2738	20	15	resistance	resistance	NOUN
gs-2738	20	16	has	have	AUX
gs-2738	20	17	been	be	AUX
gs-2738	20	18	a	a	DET
gs-2738	20	19	longstanding	longstanding	ADJ
gs-2738	20	20	goal	goal	NOUN
gs-2738	20	21	,	,	PUNCT
gs-2738	20	22	cause	cause	VERB
gs-2738	20	23	modern	modern	ADJ
gs-2738	20	24	aeds	aed	NOUN
gs-2738	20	25	could	could	AUX
gs-2738	20	26	suppress	suppress	VERB
gs-2738	20	27	seizures	seizure	NOUN
gs-2738	20	28	rather	rather	ADV
gs-2738	20	29	than	than	ADP
gs-2738	20	30	modify	modify	VERB
gs-2738	20	31	the	the	DET
gs-2738	20	32	underlying	underlie	VERB
gs-2738	20	33	disease	disease	NOUN
gs-2738	20	34	and	and	CCONJ
gs-2738	20	35	the	the	DET
gs-2738	20	36	mechanisms	mechanism	NOUN
gs-2738	20	37	underlying	underlie	VERB
gs-2738	20	38	drug	drug	NOUN
gs-2738	20	39	resistance	resistance	NOUN
gs-2738	20	40	remain	remain	VERB
gs-2738	20	41	largely	largely	ADV
gs-2738	20	42	unknown	unknown	ADJ
gs-2738	20	43	.	.	PUNCT
gs-2738	21	1	thus	thus	ADV
gs-2738	21	2	,	,	PUNCT
gs-2738	21	3	without	without	ADP
gs-2738	21	4	exploring	explore	VERB
gs-2738	21	5	and	and	CCONJ
gs-2738	21	6	rectifying	rectify	VERB
gs-2738	21	7	the	the	DET
gs-2738	21	8	underlying	underlying	ADJ
gs-2738	21	9	neuropathological	neuropathological	ADJ
gs-2738	21	10	processes	process	NOUN
gs-2738	21	11	,	,	PUNCT
gs-2738	21	12	epileptogenesis	epileptogenesis	NOUN
gs-2738	21	13	can	can	AUX
gs-2738	21	14	not	not	PART
gs-2738	21	15	be	be	AUX
gs-2738	21	16	reversed	reverse	VERB
gs-2738	21	17	.	.	PUNCT
gs-2738	22	1	among	among	ADP
gs-2738	22	2	other	other	ADJ
gs-2738	22	3	theories	theory	NOUN
gs-2738	22	4	about	about	ADP
gs-2738	22	5	current	current	ADJ
gs-2738	22	6	understanding	understanding	NOUN
gs-2738	22	7	of	of	ADP
gs-2738	22	8	epileptogenesis	epileptogenesis	NOUN
gs-2738	22	9	,	,	PUNCT
gs-2738	22	10	inflammation	inflammation	NOUN
gs-2738	22	11	has	have	AUX
gs-2738	22	12	been	be	AUX
gs-2738	22	13	implicated	implicate	VERB
gs-2738	22	14	in	in	ADP
gs-2738	22	15	the	the	DET
gs-2738	22	16	pathogenesis	pathogenesis	NOUN
gs-2738	22	17	of	of	ADP
gs-2738	22	18	some	some	DET
gs-2738	22	19	types	type	NOUN
gs-2738	22	20	of	of	ADP
gs-2738	22	21	epilepsy	epilepsy	NOUN
gs-2738	22	22	,	,	PUNCT
gs-2738	22	23	including	include	VERB
gs-2738	22	24	certain	certain	ADJ
gs-2738	22	25	types	type	NOUN
gs-2738	22	26	of	of	ADP
gs-2738	22	27	childhood	childhood	NOUN
gs-2738	22	28	epilepsies[5	epilepsies[5	NOUN
gs-2738	22	29	]	]	PUNCT
gs-2738	22	30	.	.	PUNCT
gs-2738	23	1	there	there	PRON
gs-2738	23	2	is	be	VERB
gs-2738	23	3	evidence	evidence	NOUN
gs-2738	23	4	of	of	ADP
gs-2738	23	5	ongoing	ongoing	ADJ
gs-2738	23	6	chronic	chronic	ADJ
gs-2738	23	7	neuroinflammation	neuroinflammation	NOUN
gs-2738	23	8	in	in	ADP
gs-2738	23	9	epileptic	epileptic	ADJ
gs-2738	23	10	areas	area	NOUN
gs-2738	23	11	,	,	PUNCT
gs-2738	23	12	characterized	characterize	VERB
gs-2738	23	13	by	by	ADP
gs-2738	23	14	the	the	DET
gs-2738	23	15	activation	activation	NOUN
gs-2738	23	16	of	of	ADP
gs-2738	23	17	microglia	microglia	ADJ
gs-2738	23	18	,	,	PUNCT
gs-2738	23	19	infiltration	infiltration	NOUN
gs-2738	23	20	of	of	ADP
gs-2738	23	21	immune	immune	ADJ
gs-2738	23	22	cells	cell	NOUN
gs-2738	23	23	,	,	PUNCT
gs-2738	23	24	and	and	CCONJ
gs-2738	23	25	increased	increase	VERB
gs-2738	23	26	production	production	NOUN
gs-2738	23	27	of	of	ADP
gs-2738	23	28	proinflammatory	proinflammatory	ADJ
gs-2738	23	29	mediators	mediator	NOUN
gs-2738	23	30	.	.	PUNCT
gs-2738	24	1	neuroinflammation	neuroinflammation	NOUN
gs-2738	24	2	can	can	AUX
gs-2738	24	3	persist	persist	VERB
gs-2738	24	4	even	even	ADV
gs-2738	24	5	after	after	SCONJ
gs-2738	24	6	the	the	DET
gs-2738	24	7	initial	initial	ADJ
gs-2738	24	8	trigger	trigger	NOUN
gs-2738	24	9	has	have	AUX
gs-2738	24	10	resolved	resolve	VERB
gs-2738	24	11	,	,	PUNCT
gs-2738	24	12	it	it	PRON
gs-2738	24	13	can	can	AUX
gs-2738	24	14	affect	affect	VERB
gs-2738	24	15	neuronal	neuronal	ADJ
gs-2738	24	16	excitability	excitability	NOUN
gs-2738	24	17	,	,	PUNCT
gs-2738	24	18	leads	lead	VERB
gs-2738	24	19	to	to	ADP
gs-2738	24	20	blood	blood	NOUN
gs-2738	24	21	-	-	PUNCT
gs-2738	24	22	brain	brain	NOUN
gs-2738	24	23	barrier	barrier	NOUN
gs-2738	24	24	(	(	PUNCT
gs-2738	24	25	bbb	bbb	NOUN
gs-2738	24	26	)	)	PUNCT
gs-2738	24	27	dysfunction	dysfunction	NOUN
gs-2738	24	28	,	,	PUNCT
gs-2738	24	29	impacts	impact	NOUN
gs-2738	24	30	on	on	ADP
gs-2738	24	31	seizure	seizure	NOUN
gs-2738	24	32	threshold	threshold	NOUN
gs-2738	24	33	and	and	CCONJ
gs-2738	24	34	,	,	PUNCT
gs-2738	24	35	contributes	contribute	VERB
gs-2738	24	36	to	to	ADP
gs-2738	24	37	the	the	DET
gs-2738	24	38	development	development	NOUN
gs-2738	24	39	and	and	CCONJ
gs-2738	24	40	progression	progression	NOUN
gs-2738	24	41	of	of	ADP
gs-2738	24	42	seizures	seizure	NOUN
gs-2738	24	43	[	[	X
gs-2738	24	44	6	6	NUM
gs-2738	24	45	]	]	PUNCT
gs-2738	24	46	.	.	PUNCT
gs-2738	25	1	according	accord	VERB
gs-2738	25	2	to	to	ADP
gs-2738	25	3	the	the	DET
gs-2738	25	4	previous	previous	ADJ
gs-2738	25	5	studies	study	NOUN
gs-2738	25	6	,	,	PUNCT
gs-2738	25	7	cytokine	cytokine	ADJ
gs-2738	25	8	accumulation	accumulation	NOUN
gs-2738	25	9	and	and	CCONJ
gs-2738	25	10	imbalances	imbalance	NOUN
gs-2738	25	11	in	in	ADP
gs-2738	25	12	epileptic	epileptic	ADJ
gs-2738	25	13	tissue	tissue	NOUN
gs-2738	25	14	are	be	AUX
gs-2738	25	15	markers	marker	NOUN
gs-2738	25	16	of	of	ADP
gs-2738	25	17	activated	activate	VERB
gs-2738	25	18	neuroinflammatory	neuroinflammatory	NOUN
gs-2738	25	19	processes	process	NOUN
gs-2738	25	20	involving	involve	VERB
gs-2738	25	21	cerebral	cerebral	ADJ
gs-2738	25	22	residents	resident	NOUN
gs-2738	25	23	and	and	CCONJ
gs-2738	25	24	recruited	recruit	VERB
gs-2738	25	25	immune	immune	ADJ
gs-2738	25	26	cells	cell	NOUN
gs-2738	25	27	[	[	X
gs-2738	25	28	7,8	7,8	NUM
gs-2738	25	29	]	]	PUNCT
gs-2738	25	30	.	.	PUNCT
gs-2738	26	1	cox	cox	PROPN
gs-2738	26	2	pathway	pathway	NOUN
gs-2738	26	3	metabolites	metabolite	NOUN
gs-2738	26	4	such	such	ADJ
gs-2738	26	5	as	as	ADP
gs-2738	26	6	prostaglandins	prostaglandin	NOUN
gs-2738	26	7	,	,	PUNCT
gs-2738	26	8	majorly	majorly	ADV
gs-2738	26	9	pge2	pge2	NOUN
gs-2738	26	10	,	,	PUNCT
gs-2738	26	11	are	be	AUX
gs-2738	26	12	known	know	VERB
gs-2738	26	13	that	that	PRON
gs-2738	26	14	could	could	AUX
gs-2738	26	15	influence	influence	VERB
gs-2738	26	16	central	central	ADJ
gs-2738	26	17	neural	neural	ADJ
gs-2738	26	18	inflammatory	inflammatory	ADJ
gs-2738	26	19	pathways	pathway	NOUN
gs-2738	26	20	and	and	CCONJ
gs-2738	26	21	interfere	interfere	VERB
gs-2738	26	22	mechanisms	mechanism	NOUN
gs-2738	26	23	of	of	ADP
gs-2738	26	24	epileptogenesis	epileptogenesis	NOUN
gs-2738	26	25	[	[	X
gs-2738	26	26	9	9	NUM
gs-2738	26	27	]	]	PUNCT
gs-2738	26	28	.	.	PUNCT
gs-2738	27	1	pge2	pge2	PROPN
gs-2738	27	2	may	may	AUX
gs-2738	27	3	have	have	VERB
gs-2738	27	4	indirect	indirect	ADJ
gs-2738	27	5	effects	effect	NOUN
gs-2738	27	6	on	on	ADP
gs-2738	27	7	seizure	seizure	NOUN
gs-2738	27	8	activity	activity	NOUN
gs-2738	27	9	through	through	ADP
gs-2738	27	10	its	its	PRON
gs-2738	27	11	involvement	involvement	NOUN
gs-2738	27	12	in	in	ADP
gs-2738	27	13	inflammation	inflammation	NOUN
gs-2738	27	14	and	and	CCONJ
gs-2738	27	15	neuronal	neuronal	ADJ
gs-2738	27	16	excitability	excitability	NOUN
gs-2738	27	17	.	.	PUNCT
gs-2738	28	1	as	as	SCONJ
gs-2738	28	2	it	it	PRON
gs-2738	28	3	known	know	VERB
gs-2738	28	4	cox-2	cox-2	ADJ
gs-2738	28	5	acts	act	NOUN
gs-2738	28	6	as	as	ADP
gs-2738	28	7	rate	rate	NOUN
gs-2738	28	8	-	-	PUNCT
gs-2738	28	9	limiting	limit	VERB
gs-2738	28	10	enzyme	enzyme	NOUN
gs-2738	28	11	for	for	ADP
gs-2738	28	12	pge2	pge2	NOUN
gs-2738	28	13	production	production	NOUN
gs-2738	28	14	,	,	PUNCT
gs-2738	28	15	due	due	ADP
gs-2738	28	16	to	to	ADP
gs-2738	28	17	influence	influence	NOUN
gs-2738	28	18	of	of	ADP
gs-2738	28	19	proinflammatory	proinflammatory	ADJ
gs-2738	28	20	cytokines	cytokine	NOUN
gs-2738	28	21	cox-2	cox-2	NOUN
gs-2738	28	22	expression	expression	NOUN
gs-2738	28	23	is	be	AUX
gs-2738	28	24	promptly	promptly	ADV
gs-2738	28	25	induced	induce	VERB
gs-2738	28	26	in	in	ADP
gs-2738	28	27	blood	blood	NOUN
gs-2738	28	28	-	-	PUNCT
gs-2738	28	29	brain	brain	NOUN
gs-2738	28	30	-	-	PUNCT
gs-2738	28	31	barrier	barrier	NOUN
gs-2738	28	32	endothelium[10	endothelium[10	NOUN
gs-2738	28	33	]	]	PUNCT
gs-2738	28	34	.	.	PUNCT
gs-2738	29	1	in	in	ADP
gs-2738	29	2	several	several	ADJ
gs-2738	29	3	rodent	rodent	NOUN
gs-2738	29	4	models	model	NOUN
gs-2738	29	5	of	of	ADP
gs-2738	29	6	drug	drug	NOUN
gs-2738	29	7	-	-	PUNCT
gs-2738	29	8	resistant	resistant	ADJ
gs-2738	29	9	epilepsy	epilepsy	NOUN
gs-2738	29	10	,	,	PUNCT
gs-2738	29	11	blockade	blockade	NOUN
gs-2738	29	12	of	of	ADP
gs-2738	29	13	the	the	DET
gs-2738	29	14	c0x2	c0x2	NOUN
gs-2738	29	15	-	-	PUNCT
gs-2738	29	16	pge2	pge2	NOUN
gs-2738	29	17	pathway	pathway	NOUN
gs-2738	29	18	,	,	PUNCT
gs-2738	29	19	prostaglandin	prostaglandin	NOUN
gs-2738	29	20	e	e	NOUN
gs-2738	29	21	receptor	receptor	NOUN
gs-2738	29	22	2	2	NUM
gs-2738	29	23	(	(	PUNCT
gs-2738	29	24	ep2	ep2	NOUN
gs-2738	29	25	)	)	PUNCT
gs-2738	29	26	receptor	receptor	NOUN
gs-2738	29	27	transitory	transitory	ADJ
gs-2738	29	28	inhibition	inhibition	NOUN
gs-2738	29	29	reduced	reduce	VERB
gs-2738	29	30	the	the	DET
gs-2738	29	31	degree	degree	NOUN
gs-2738	29	32	of	of	ADP
gs-2738	29	33	bloodbrain	bloodbrain	NOUN
gs-2738	29	34	barrier	barrier	NOUN
gs-2738	29	35	dysfunction	dysfunction	NOUN
gs-2738	29	36	,	,	PUNCT
gs-2738	29	37	decreased	decrease	VERB
gs-2738	29	38	cytokine	cytokine	ADJ
gs-2738	29	39	production	production	NOUN
gs-2738	29	40	,	,	PUNCT
gs-2738	29	41	reactive	reactive	ADJ
gs-2738	29	42	gliosis	gliosis	NOUN
gs-2738	29	43	and	and	CCONJ
gs-2738	29	44	seizure	seizure	NOUN
gs-2738	29	45	-	-	PUNCT
gs-2738	29	46	promoted	promote	VERB
gs-2738	29	47	functional	functional	ADJ
gs-2738	29	48	deficits	deficit	NOUN
gs-2738	29	49	thus	thus	ADV
gs-2738	29	50	appear	appear	VERB
gs-2738	29	51	having	have	VERB
gs-2738	29	52	role	role	NOUN
gs-2738	29	53	in	in	ADP
gs-2738	29	54	anti	anti	ADJ
gs-2738	29	55	-	-	ADJ
gs-2738	29	56	inflammatory	inflammatory	ADJ
gs-2738	29	57	cascade	cascade	NOUN
gs-2738	29	58	and	and	CCONJ
gs-2738	29	59	neuroprotection	neuroprotection	NOUN
gs-2738	29	60	[	[	X
gs-2738	29	61	11	11	NUM
gs-2738	29	62	-	-	SYM
gs-2738	29	63	14	14	NUM
gs-2738	29	64	]	]	PUNCT
gs-2738	29	65	.	.	PUNCT
gs-2738	30	1	amounting	amount	VERB
gs-2738	30	2	evidence	evidence	NOUN
gs-2738	30	3	also	also	ADV
gs-2738	30	4	suggested	suggest	VERB
gs-2738	30	5	that	that	SCONJ
gs-2738	30	6	increased	increase	VERB
gs-2738	30	7	pge2	pge2	NOUN
gs-2738	30	8	biosynthesis	biosynthesis	NOUN
gs-2738	30	9	following	follow	VERB
gs-2738	30	10	seizure	seizure	NOUN
gs-2738	30	11	may	may	AUX
gs-2738	30	12	upregulate	upregulate	VERB
gs-2738	30	13	the	the	DET
gs-2738	30	14	multidrug	multidrug	NOUN
gs-2738	30	15	efflux	efflux	NOUN
gs-2738	30	16	transporters	transporter	NOUN
gs-2738	30	17	,	,	PUNCT
gs-2738	30	18	p	p	NOUN
gs-2738	30	19	-	-	PUNCT
gs-2738	30	20	glycoproteins	glycoprotein	NOUN
gs-2738	30	21	(	(	PUNCT
gs-2738	30	22	p	p	NOUN
gs-2738	30	23	-	-	PUNCT
gs-2738	30	24	gp	gp	NOUN
gs-2738	30	25	)	)	PUNCT
gs-2738	30	26	,	,	PUNCT
gs-2738	30	27	at	at	ADP
gs-2738	30	28	hematoencephalic	hematoencephalic	ADJ
gs-2738	30	29	barrier[15	barrier[15	PROPN
gs-2738	30	30	]	]	PUNCT
gs-2738	30	31	.	.	PUNCT
gs-2738	31	1	this	this	DET
gs-2738	31	2	upregulation	upregulation	NOUN
gs-2738	31	3	could	could	AUX
gs-2738	31	4	contribute	contribute	VERB
gs-2738	31	5	to	to	ADP
gs-2738	31	6	an	an	DET
gs-2738	31	7	increased	increase	VERB
gs-2738	31	8	efflux	efflux	NOUN
gs-2738	31	9	of	of	ADP
gs-2738	31	10	prescribed	prescribe	VERB
gs-2738	31	11	aeds	aed	NOUN
gs-2738	31	12	,	,	PUNCT
gs-2738	31	13	potentially	potentially	ADV
gs-2738	31	14	leading	lead	VERB
gs-2738	31	15	to	to	ADP
gs-2738	31	16	reduced	reduce	VERB
gs-2738	31	17	treatment	treatment	NOUN
gs-2738	31	18	efficacy	efficacy	NOUN
gs-2738	31	19	.	.	PUNCT
gs-2738	32	1	to	to	PART
gs-2738	32	2	treat	treat	VERB
gs-2738	32	3	epilepsy	epilepsy	NOUN
gs-2738	32	4	and	and	CCONJ
gs-2738	32	5	to	to	PART
gs-2738	32	6	increase	increase	VERB
gs-2738	32	7	the	the	DET
gs-2738	32	8	effectiveness	effectiveness	NOUN
gs-2738	32	9	of	of	ADP
gs-2738	32	10	aeds	aed	NOUN
gs-2738	32	11	,	,	PUNCT
gs-2738	32	12	blocking	block	VERB
gs-2738	32	13	this	this	DET
gs-2738	32	14	increase	increase	NOUN
gs-2738	32	15	in	in	ADP
gs-2738	32	16	pge2	pge2	NOUN
gs-2738	32	17	levels	level	NOUN
gs-2738	32	18	may	may	AUX
gs-2738	32	19	be	be	AUX
gs-2738	32	20	beneficial	beneficial	ADJ
gs-2738	32	21	[	[	X
gs-2738	32	22	16	16	NUM
gs-2738	32	23	]	]	PUNCT
gs-2738	32	24	.	.	PUNCT
gs-2738	33	1	pge2	pge2	NOUN
gs-2738	33	2	biosynthesis	biosynthesis	NOUN
gs-2738	33	3	could	could	AUX
gs-2738	33	4	be	be	AUX
gs-2738	33	5	affected	affect	VERB
gs-2738	33	6	by	by	ADP
gs-2738	33	7	prescribed	prescribed	ADJ
gs-2738	33	8	aeds	aed	NOUN
gs-2738	33	9	,	,	PUNCT
gs-2738	33	10	georgian	georgian	ADJ
gs-2738	33	11	scientists/ქართველი	scientists/ქართველი	NOUN
gs-2738	33	12	მეცნიერები	მეცნიერები	NOUN
gs-2738	33	13	ტ.	ტ.	VERB
gs-2738	33	14	6	6	NUM
gs-2738	33	15	n	n	NUM
gs-2738	33	16	1	1	NUM
gs-2738	33	17	,	,	PUNCT
gs-2738	33	18	2024	2024	NUM
gs-2738	33	19	291	291	NUM
gs-2738	33	20	therefore	therefore	ADV
gs-2738	33	21	cyclooxygenase-2	cyclooxygenase-2	NUM
gs-2738	33	22	and	and	CCONJ
gs-2738	33	23	pge2	pge2	NOUN
gs-2738	33	24	receptor	receptor	NOUN
gs-2738	33	25	may	may	AUX
gs-2738	33	26	proposed	propose	VERB
gs-2738	33	27	as	as	ADP
gs-2738	33	28	target	target	NOUN
gs-2738	33	29	for	for	ADP
gs-2738	33	30	new	new	ADJ
gs-2738	33	31	disease	disease	NOUN
gs-2738	33	32	modifying	modify	VERB
gs-2738	33	33	treatments	treatment	NOUN
gs-2738	33	34	with	with	ADP
gs-2738	33	35	goal	goal	NOUN
gs-2738	33	36	to	to	PART
gs-2738	33	37	improve	improve	VERB
gs-2738	33	38	and	and	CCONJ
gs-2738	33	39	restore	restore	VERB
gs-2738	33	40	seizure	seizure	NOUN
gs-2738	33	41	pharmacosensitivity	pharmacosensitivity	NOUN
gs-2738	33	42	and	and	CCONJ
gs-2738	33	43	improve	improve	VERB
gs-2738	33	44	therapeutic	therapeutic	ADJ
gs-2738	33	45	outcomes	outcome	NOUN
gs-2738	34	1	[	[	X
gs-2738	34	2	17,18	17,18	NUM
gs-2738	34	3	]	]	X
gs-2738	34	4	.	.	PUNCT
gs-2738	35	1	however	however	ADV
gs-2738	35	2	,	,	PUNCT
gs-2738	35	3	the	the	DET
gs-2738	35	4	reported	report	VERB
gs-2738	35	5	studies	study	NOUN
gs-2738	35	6	rely	rely	VERB
gs-2738	35	7	mostly	mostly	ADV
gs-2738	35	8	on	on	ADP
gs-2738	35	9	experimental	experimental	ADJ
gs-2738	35	10	evidence	evidence	NOUN
gs-2738	35	11	regarding	regard	VERB
gs-2738	35	12	immediate	immediate	ADJ
gs-2738	35	13	postictal	postictal	ADJ
gs-2738	35	14	changes	change	NOUN
gs-2738	35	15	in	in	ADP
gs-2738	35	16	proinflammatory	proinflammatory	ADJ
gs-2738	35	17	markers	marker	NOUN
gs-2738	35	18	,	,	PUNCT
gs-2738	35	19	but	but	CCONJ
gs-2738	35	20	their	their	PRON
gs-2738	35	21	role	role	NOUN
gs-2738	35	22	in	in	ADP
gs-2738	35	23	the	the	DET
gs-2738	35	24	genesis	genesis	NOUN
gs-2738	35	25	of	of	ADP
gs-2738	35	26	epilepsy	epilepsy	NOUN
gs-2738	35	27	and	and	CCONJ
gs-2738	35	28	clinical	clinical	ADJ
gs-2738	35	29	phenotype	phenotype	NOUN
gs-2738	35	30	or	or	CCONJ
gs-2738	35	31	drug	drug	NOUN
gs-2738	35	32	responsiveness	responsiveness	NOUN
gs-2738	35	33	is	be	AUX
gs-2738	35	34	not	not	PART
gs-2738	35	35	clearly	clearly	ADV
gs-2738	35	36	defined	define	VERB
gs-2738	35	37	.	.	PUNCT
gs-2738	36	1	aed	aed	NOUN
gs-2738	36	2	resistance	resistance	NOUN
gs-2738	36	3	is	be	AUX
gs-2738	36	4	very	very	ADV
gs-2738	36	5	probably	probably	ADV
gs-2738	36	6	not	not	PART
gs-2738	36	7	caused	cause	VERB
gs-2738	36	8	by	by	ADP
gs-2738	36	9	a	a	DET
gs-2738	36	10	single	single	ADJ
gs-2738	36	11	mechanism	mechanism	NOUN
gs-2738	36	12	.	.	PUNCT
gs-2738	37	1	thus	thus	ADV
gs-2738	37	2	,	,	PUNCT
gs-2738	37	3	exploring	explore	VERB
gs-2738	37	4	responsible	responsible	ADJ
gs-2738	37	5	biological	biological	ADJ
gs-2738	37	6	pathway	pathway	NOUN
gs-2738	37	7	from	from	ADP
gs-2738	37	8	bench	bench	NOUN
gs-2738	37	9	to	to	ADP
gs-2738	37	10	bedside	bedside	NOUN
gs-2738	37	11	is	be	AUX
gs-2738	37	12	a	a	DET
gs-2738	37	13	major	major	ADJ
gs-2738	37	14	challenge	challenge	NOUN
gs-2738	37	15	towards	towards	ADP
gs-2738	37	16	precision	precision	NOUN
gs-2738	37	17	medicine	medicine	NOUN
gs-2738	37	18	of	of	ADP
gs-2738	37	19	epilepsy	epilepsy	PROPN
gs-2738	37	20	.	.	PUNCT
gs-2738	38	1	in	in	ADP
gs-2738	38	2	this	this	DET
gs-2738	38	3	case	case	NOUN
gs-2738	38	4	-	-	PUNCT
gs-2738	38	5	control	control	NOUN
gs-2738	38	6	study	study	NOUN
gs-2738	38	7	we	we	PRON
gs-2738	38	8	compared	compare	VERB
gs-2738	38	9	pge2	pge2	NOUN
gs-2738	38	10	levels	level	NOUN
gs-2738	38	11	(	(	PUNCT
gs-2738	38	12	median	median	ADJ
gs-2738	38	13	,	,	PUNCT
gs-2738	38	14	pg	pg	PROPN
gs-2738	38	15	/	/	SYM
gs-2738	38	16	ml	ml	NOUN
gs-2738	38	17	)	)	PUNCT
gs-2738	38	18	in	in	ADP
gs-2738	38	19	sera	sera	NOUN
gs-2738	38	20	of	of	ADP
gs-2738	38	21	patients	patient	NOUN
gs-2738	38	22	with	with	ADP
gs-2738	38	23	different	different	ADJ
gs-2738	38	24	types	type	NOUN
gs-2738	38	25	of	of	ADP
gs-2738	38	26	epilepsy	epilepsy	NOUN
gs-2738	38	27	.	.	PUNCT
gs-2738	39	1	pge2	pge2	NOUN
gs-2738	39	2	profiles	profile	NOUN
gs-2738	39	3	of	of	ADP
gs-2738	39	4	patients	patient	NOUN
gs-2738	39	5	on	on	ADP
gs-2738	39	6	the	the	DET
gs-2738	39	7	basis	basis	NOUN
gs-2738	39	8	of	of	ADP
gs-2738	39	9	recieving	recieve	VERB
gs-2738	39	10	drug	drug	NOUN
gs-2738	39	11	and	and	CCONJ
gs-2738	39	12	responsiveness	responsiveness	NOUN
gs-2738	39	13	were	be	AUX
gs-2738	39	14	also	also	ADV
gs-2738	39	15	analyzed	analyze	VERB
gs-2738	39	16	,	,	PUNCT
gs-2738	39	17	aiming	aim	VERB
gs-2738	39	18	to	to	PART
gs-2738	39	19	assess	assess	VERB
gs-2738	39	20	importance	importance	NOUN
gs-2738	39	21	of	of	ADP
gs-2738	39	22	epilepsyassociated	epilepsyassociate	VERB
gs-2738	39	23	inflammation	inflammation	NOUN
gs-2738	39	24	and	and	CCONJ
gs-2738	39	25	possible	possible	ADJ
gs-2738	39	26	link	link	NOUN
gs-2738	39	27	with	with	ADP
gs-2738	39	28	antiepileptic	antiepileptic	ADJ
gs-2738	39	29	drug	drug	NOUN
gs-2738	39	30	response	response	NOUN
gs-2738	39	31	,	,	PUNCT
gs-2738	39	32	which	which	PRON
gs-2738	39	33	could	could	AUX
gs-2738	39	34	be	be	AUX
gs-2738	39	35	a	a	DET
gs-2738	39	36	new	new	ADJ
gs-2738	39	37	target	target	NOUN
gs-2738	39	38	biomarker	biomarker	NOUN
gs-2738	39	39	in	in	ADP
gs-2738	39	40	the	the	DET
gs-2738	39	41	future	future	NOUN
gs-2738	39	42	to	to	PART
gs-2738	39	43	develop	develop	VERB
gs-2738	39	44	therapies	therapy	NOUN
gs-2738	39	45	overcoming	overcome	VERB
gs-2738	39	46	drug	drug	NOUN
gs-2738	39	47	resistance	resistance	NOUN
gs-2738	39	48	.	.	PUNCT
gs-2738	40	1	materials	material	NOUN
gs-2738	40	2	and	and	CCONJ
gs-2738	40	3	methods	method	NOUN
gs-2738	40	4	participants	participant	NOUN
gs-2738	40	5	were	be	AUX
gs-2738	40	6	recruited	recruit	VERB
gs-2738	40	7	from	from	ADP
gs-2738	40	8	the	the	DET
gs-2738	40	9	zhvania	zhvania	PROPN
gs-2738	40	10	academic	academic	PROPN
gs-2738	40	11	clinic	clinic	NOUN
gs-2738	40	12	of	of	ADP
gs-2738	40	13	pediatrics	pediatric	NOUN
gs-2738	40	14	in	in	ADP
gs-2738	40	15	tbilisi	tbilisi	PROPN
gs-2738	40	16	,	,	PUNCT
gs-2738	40	17	georgia	georgia	PROPN
gs-2738	40	18	and	and	CCONJ
gs-2738	40	19	grouped	group	VERB
gs-2738	40	20	as	as	SCONJ
gs-2738	40	21	follows	follow	VERB
gs-2738	40	22	:	:	PUNCT
gs-2738	40	23	group	group	PROPN
gs-2738	40	24	1a	1a	PROPN
gs-2738	40	25	consisted	consist	VERB
gs-2738	40	26	of	of	ADP
gs-2738	40	27	seizure	seizure	NOUN
gs-2738	40	28	-	-	PUNCT
gs-2738	40	29	free	free	ADJ
gs-2738	40	30	epilepsy	epilepsy	NOUN
gs-2738	40	31	patients	patient	NOUN
gs-2738	40	32	on	on	ADP
gs-2738	40	33	aed	aed	NOUN
gs-2738	40	34	therapy	therapy	NOUN
gs-2738	40	35	for	for	ADP
gs-2738	40	36	at	at	ADV
gs-2738	40	37	least	least	ADV
gs-2738	40	38	one	one	NUM
gs-2738	40	39	year	year	NOUN
gs-2738	40	40	,	,	PUNCT
gs-2738	40	41	group	group	NOUN
gs-2738	40	42	1b	1b	NUM
gs-2738	40	43	included	include	VERB
gs-2738	40	44	subjects	subject	NOUN
gs-2738	40	45	with	with	ADP
gs-2738	40	46	drug	drug	NOUN
gs-2738	40	47	-	-	PUNCT
gs-2738	40	48	resistant	resistant	ADJ
gs-2738	40	49	epilepsies	epilepsy	NOUN
gs-2738	40	50	experiencing	experience	VERB
gs-2738	40	51	recurrent	recurrent	ADJ
gs-2738	40	52	seizures	seizure	NOUN
gs-2738	40	53	despite	despite	SCONJ
gs-2738	40	54	treatment	treatment	NOUN
gs-2738	40	55	with	with	ADP
gs-2738	40	56	two	two	NUM
gs-2738	40	57	first	first	ADJ
gs-2738	40	58	-	-	PUNCT
gs-2738	40	59	line	line	NOUN
gs-2738	40	60	aeds	aed	NOUN
gs-2738	40	61	and	and	CCONJ
gs-2738	40	62	diagnosed	diagnose	VERB
gs-2738	40	63	with	with	ADP
gs-2738	40	64	epileptic	epileptic	ADJ
gs-2738	40	65	encephalopathies	encephalopathy	NOUN
gs-2738	40	66	,	,	PUNCT
gs-2738	40	67	and	and	CCONJ
gs-2738	40	68	group	group	NOUN
gs-2738	40	69	2	2	NUM
gs-2738	40	70	comprised	comprise	VERB
gs-2738	40	71	afebrile	afebrile	ADJ
gs-2738	40	72	controls	control	NOUN
gs-2738	40	73	without	without	ADP
gs-2738	40	74	neurological	neurological	ADJ
gs-2738	40	75	disorders	disorder	NOUN
gs-2738	40	76	,	,	PUNCT
gs-2738	40	77	matched	match	VERB
gs-2738	40	78	for	for	ADP
gs-2738	40	79	age	age	NOUN
gs-2738	40	80	,	,	PUNCT
gs-2738	40	81	gender	gender	NOUN
gs-2738	40	82	,	,	PUNCT
gs-2738	40	83	and	and	CCONJ
gs-2738	40	84	ethnicity	ethnicity	NOUN
gs-2738	40	85	.	.	PUNCT
gs-2738	41	1	exclusion	exclusion	NOUN
gs-2738	41	2	and	and	CCONJ
gs-2738	41	3	inclusion	inclusion	NOUN
gs-2738	41	4	criteria	criterion	NOUN
gs-2738	41	5	are	be	AUX
gs-2738	41	6	detailed	detail	VERB
gs-2738	41	7	in	in	ADP
gs-2738	41	8	table	table	NOUN
gs-2738	41	9	1	1	NUM
gs-2738	41	10	.	.	PUNCT
gs-2738	42	1	the	the	DET
gs-2738	42	2	exclusion	exclusion	NOUN
gs-2738	42	3	and	and	CCONJ
gs-2738	42	4	inclusion	inclusion	NOUN
gs-2738	42	5	criteria	criterion	NOUN
gs-2738	42	6	from	from	ADP
gs-2738	42	7	study	study	NOUN
gs-2738	42	8	groups	group	NOUN
gs-2738	42	9	were	be	AUX
gs-2738	42	10	as	as	SCONJ
gs-2738	42	11	follows	follow	VERB
gs-2738	42	12	in	in	ADP
gs-2738	42	13	table	table	NOUN
gs-2738	42	14	1	1	NUM
gs-2738	42	15	.	.	PUNCT
gs-2738	42	16	table	table	NOUN
gs-2738	42	17	1	1	NUM
gs-2738	42	18	:	:	PUNCT
gs-2738	42	19	study	study	VERB
gs-2738	42	20	subject	subject	ADJ
gs-2738	42	21	exclusion	exclusion	NOUN
gs-2738	42	22	and	and	CCONJ
gs-2738	42	23	inclusion	inclusion	NOUN
gs-2738	42	24	criteria	criterion	NOUN
gs-2738	42	25	exclusion	exclusion	NOUN
gs-2738	42	26	inclusion	inclusion	NOUN
gs-2738	42	27	acute	acute	NOUN
gs-2738	42	28	somatic	somatic	ADJ
gs-2738	42	29	illnesses	illness	NOUN
gs-2738	42	30	autoimmune	autoimmune	ADJ
gs-2738	42	31	diseases	disease	VERB
gs-2738	42	32	recent	recent	ADJ
gs-2738	42	33	infections	infection	NOUN
gs-2738	42	34	regular	regular	ADJ
gs-2738	42	35	consumption	consumption	NOUN
gs-2738	42	36	of	of	ADP
gs-2738	42	37	the	the	DET
gs-2738	42	38	cox-2inhibiting	cox-2inhibite	VERB
gs-2738	42	39	drugs	drug	NOUN
gs-2738	42	40	receiving	receive	VERB
gs-2738	42	41	nonsteroidal	nonsteroidal	NOUN
gs-2738	42	42	antiinflammatory	antiinflammatory	NOUN
gs-2738	42	43	drugs	drug	NOUN
gs-2738	42	44	(	(	PUNCT
gs-2738	42	45	nsaids	nsaids	PROPN
gs-2738	42	46	)	)	PUNCT
gs-2738	42	47	performing	perform	VERB
gs-2738	42	48	regular	regular	ADJ
gs-2738	42	49	vigorous	vigorous	ADJ
gs-2738	42	50	physical	physical	ADJ
gs-2738	42	51	activity	activity	NOUN
gs-2738	42	52	*	*	PUNCT
gs-2738	42	53	age	age	NOUN
gs-2738	42	54	0	0	NUM
gs-2738	42	55	-	-	SYM
gs-2738	42	56	16	16	NUM
gs-2738	42	57	confirmed	confirm	VERB
gs-2738	42	58	diagnosis	diagnosis	NOUN
gs-2738	42	59	of	of	ADP
gs-2738	42	60	epilepsy	epilepsy	NOUN
gs-2738	42	61	*	*	PUNCT
gs-2738	42	62	defined	define	VERB
gs-2738	42	63	by	by	ADP
gs-2738	42	64	the	the	DET
gs-2738	42	65	centers	center	NOUN
gs-2738	42	66	for	for	ADP
gs-2738	42	67	disease	disease	NOUN
gs-2738	42	68	control	control	NOUN
gs-2738	42	69	and	and	CCONJ
gs-2738	42	70	prevention	prevention	NOUN
gs-2738	42	71	[	[	X
gs-2738	42	72	19	19	NUM
gs-2738	42	73	]	]	PUNCT
gs-2738	42	74	.	.	PUNCT
gs-2738	43	1	data	datum	NOUN
gs-2738	43	2	collection	collection	PROPN
gs-2738	43	3	:	:	PUNCT
gs-2738	43	4	comprehensive	comprehensive	ADJ
gs-2738	43	5	systemic	systemic	ADJ
gs-2738	43	6	and	and	CCONJ
gs-2738	43	7	neurological	neurological	ADJ
gs-2738	43	8	assessments	assessment	NOUN
gs-2738	43	9	,	,	PUNCT
gs-2738	43	10	eegs	eeg	NOUN
gs-2738	43	11	,	,	PUNCT
gs-2738	43	12	and	and	CCONJ
gs-2738	43	13	medical	medical	ADJ
gs-2738	43	14	record	record	NOUN
gs-2738	43	15	reviews	review	NOUN
gs-2738	43	16	were	be	AUX
gs-2738	43	17	conducted	conduct	VERB
gs-2738	43	18	to	to	PART
gs-2738	43	19	gather	gather	VERB
gs-2738	43	20	demographic	demographic	ADJ
gs-2738	43	21	and	and	CCONJ
gs-2738	43	22	clinical	clinical	ADJ
gs-2738	43	23	information	information	NOUN
gs-2738	43	24	,	,	PUNCT
gs-2738	43	25	epilepsy	epilepsy	NOUN
gs-2738	43	26	subtype	subtype	NOUN
gs-2738	43	27	,	,	PUNCT
gs-2738	43	28	disease	disease	NOUN
gs-2738	43	29	duration	duration	NOUN
gs-2738	43	30	,	,	PUNCT
gs-2738	43	31	seizure	seizure	NOUN
gs-2738	43	32	types	type	NOUN
gs-2738	43	33	and	and	CCONJ
gs-2738	43	34	outcomes	outcome	NOUN
gs-2738	43	35	,	,	PUNCT
gs-2738	43	36	pre	pre	ADJ
gs-2738	43	37	-	-	ADJ
gs-2738	43	38	existing	existing	ADJ
gs-2738	43	39	investigations	investigation	NOUN
gs-2738	43	40	and	and	CCONJ
gs-2738	43	41	treatment	treatment	NOUN
gs-2738	43	42	,	,	PUNCT
gs-2738	43	43	including	include	VERB
gs-2738	43	44	antiepileptic	antiepileptic	ADJ
gs-2738	43	45	georgian	georgian	ADJ
gs-2738	43	46	scientists/ქართველი	scientists/ქართველი	NOUN
gs-2738	43	47	მეცნიერები	მეცნიერები	NOUN
gs-2738	43	48	ტ.	ტ.	VERB
gs-2738	43	49	6	6	NUM
gs-2738	43	50	n	n	NUM
gs-2738	43	51	1	1	NUM
gs-2738	43	52	,	,	PUNCT
gs-2738	43	53	2024	2024	NUM
gs-2738	43	54	292	292	NUM
gs-2738	43	55	medication	medication	NOUN
gs-2738	43	56	usage	usage	NOUN
gs-2738	43	57	and	and	CCONJ
gs-2738	43	58	treatment	treatment	NOUN
gs-2738	43	59	response	response	NOUN
gs-2738	43	60	categorizations	categorization	NOUN
gs-2738	43	61	such	such	ADJ
gs-2738	43	62	as	as	ADP
gs-2738	43	63	"	"	PUNCT
gs-2738	43	64	valproate	valproate	ADJ
gs-2738	43	65	responders	responder	NOUN
gs-2738	43	66	"	"	PUNCT
gs-2738	43	67	and	and	CCONJ
gs-2738	43	68	"	"	PUNCT
gs-2738	43	69	valproate	valproate	ADJ
gs-2738	43	70	non	non	NOUN
gs-2738	43	71	-	-	NOUN
gs-2738	43	72	responders	responder	NOUN
gs-2738	43	73	.	.	PUNCT
gs-2738	43	74	"	"	PUNCT
gs-2738	44	1	blood	blood	NOUN
gs-2738	44	2	sample	sample	NOUN
gs-2738	44	3	collection	collection	NOUN
gs-2738	44	4	:	:	PUNCT
gs-2738	44	5	venous	venous	ADJ
gs-2738	44	6	blood	blood	NOUN
gs-2738	44	7	samples	sample	NOUN
gs-2738	44	8	were	be	AUX
gs-2738	44	9	collected	collect	VERB
gs-2738	44	10	under	under	ADP
gs-2738	44	11	sterile	sterile	ADJ
gs-2738	44	12	conditions	condition	NOUN
gs-2738	44	13	,	,	PUNCT
gs-2738	44	14	processed	process	VERB
gs-2738	44	15	,	,	PUNCT
gs-2738	44	16	and	and	CCONJ
gs-2738	44	17	dispatched	dispatch	VERB
gs-2738	44	18	to	to	ADP
gs-2738	44	19	the	the	DET
gs-2738	44	20	laboratory	laboratory	NOUN
gs-2738	44	21	for	for	ADP
gs-2738	44	22	further	further	ADJ
gs-2738	44	23	analysis	analysis	NOUN
gs-2738	44	24	,	,	PUNCT
gs-2738	44	25	including	include	VERB
gs-2738	44	26	systemic	systemic	ADJ
gs-2738	44	27	lab	lab	NOUN
gs-2738	44	28	measurements	measurement	NOUN
gs-2738	44	29	and	and	CCONJ
gs-2738	44	30	assessment	assessment	NOUN
gs-2738	44	31	of	of	ADP
gs-2738	44	32	prescribed	prescribe	VERB
gs-2738	44	33	aed	aed	NOUN
gs-2738	44	34	serum	serum	NOUN
gs-2738	44	35	levels	level	NOUN
gs-2738	44	36	.	.	PUNCT
gs-2738	45	1	cytokine	cytokine	ADJ
gs-2738	45	2	analysis	analysis	NOUN
gs-2738	45	3	:	:	PUNCT
gs-2738	45	4	prostaglandin	prostaglandin	NOUN
gs-2738	45	5	e2	e2	NOUN
gs-2738	45	6	levels	level	NOUN
gs-2738	45	7	were	be	AUX
gs-2738	45	8	measured	measure	VERB
gs-2738	45	9	using	use	VERB
gs-2738	45	10	elisa	elisa	NOUN
gs-2738	45	11	kits	kit	NOUN
gs-2738	45	12	.	.	PUNCT
gs-2738	46	1	statistical	statistical	ADJ
gs-2738	46	2	analysis	analysis	NOUN
gs-2738	46	3	was	be	AUX
gs-2738	46	4	performed	perform	VERB
gs-2738	46	5	using	use	VERB
gs-2738	46	6	spss	spss	PROPN
gs-2738	46	7	21	21	NUM
gs-2738	46	8	,	,	PUNCT
gs-2738	46	9	with	with	ADP
gs-2738	46	10	continuous	continuous	ADJ
gs-2738	46	11	variables	variable	NOUN
gs-2738	46	12	presented	present	VERB
gs-2738	46	13	as	as	SCONJ
gs-2738	46	14	means	mean	VERB
gs-2738	46	15	±	±	NUM
gs-2738	46	16	sd	sd	NOUN
gs-2738	46	17	for	for	ADP
gs-2738	46	18	normal	normal	ADJ
gs-2738	46	19	distribution	distribution	NOUN
gs-2738	46	20	and	and	CCONJ
gs-2738	46	21	as	as	ADP
gs-2738	46	22	median	median	ADJ
gs-2738	46	23	interquartile	interquartile	NOUN
gs-2738	46	24	range	range	NOUN
gs-2738	46	25	(	(	PUNCT
gs-2738	46	26	iqr	iqr	NOUN
gs-2738	46	27	)	)	PUNCT
gs-2738	46	28	for	for	ADP
gs-2738	46	29	nonparametric	nonparametric	NOUN
gs-2738	46	30	data	datum	NOUN
gs-2738	46	31	.	.	PUNCT
gs-2738	47	1	data	datum	NOUN
gs-2738	47	2	comparison	comparison	NOUN
gs-2738	47	3	utilized	utilize	VERB
gs-2738	47	4	kruskal	kruskal	PROPN
gs-2738	47	5	–	–	PUNCT
gs-2738	47	6	wallis	wallis	PROPN
gs-2738	47	7	and	and	CCONJ
gs-2738	47	8	mann	mann	PROPN
gs-2738	47	9	–	–	PUNCT
gs-2738	47	10	whitney	whitney	PROPN
gs-2738	47	11	u	u	NOUN
gs-2738	47	12	tests	test	NOUN
gs-2738	47	13	,	,	PUNCT
gs-2738	47	14	and	and	CCONJ
gs-2738	47	15	graphical	graphical	ADJ
gs-2738	47	16	representation	representation	NOUN
gs-2738	47	17	was	be	AUX
gs-2738	47	18	created	create	VERB
gs-2738	47	19	using	use	VERB
gs-2738	47	20	graphpad	graphpad	NOUN
gs-2738	47	21	prism	prism	NOUN
gs-2738	47	22	8	8	NUM
gs-2738	47	23	.	.	PUNCT
gs-2738	48	1	ethical	ethical	ADJ
gs-2738	48	2	considerations	consideration	NOUN
gs-2738	48	3	:	:	PUNCT
gs-2738	48	4	the	the	DET
gs-2738	48	5	study	study	NOUN
gs-2738	48	6	adhered	adhere	VERB
gs-2738	48	7	to	to	ADP
gs-2738	48	8	the	the	DET
gs-2738	48	9	declaration	declaration	NOUN
gs-2738	48	10	of	of	ADP
gs-2738	48	11	helsinki	helsinki	PROPN
gs-2738	48	12	principles	principle	NOUN
gs-2738	48	13	and	and	CCONJ
gs-2738	48	14	was	be	AUX
gs-2738	48	15	approved	approve	VERB
gs-2738	48	16	by	by	ADP
gs-2738	48	17	the	the	DET
gs-2738	48	18	tbilisi	tbilisi	PROPN
gs-2738	48	19	state	state	PROPN
gs-2738	48	20	medical	medical	PROPN
gs-2738	48	21	university	university	PROPN
gs-2738	48	22	research	research	NOUN
gs-2738	48	23	ethics	ethic	NOUN
gs-2738	48	24	committee	committee	PROPN
gs-2738	48	25	(	(	PUNCT
gs-2738	48	26	10.11.2019	10.11.2019	NUM
gs-2738	48	27	)	)	PUNCT
gs-2738	48	28	.	.	PUNCT
gs-2738	49	1	results	result	NOUN
gs-2738	49	2	based	base	VERB
gs-2738	49	3	on	on	ADP
gs-2738	49	4	a	a	DET
gs-2738	49	5	retrospective	retrospective	ADJ
gs-2738	49	6	review	review	NOUN
gs-2738	49	7	of	of	ADP
gs-2738	49	8	clinical	clinical	ADJ
gs-2738	49	9	and	and	CCONJ
gs-2738	49	10	paraclinical	paraclinical	ADJ
gs-2738	49	11	data	data	NOUN
gs-2738	49	12	patients	patient	NOUN
gs-2738	49	13	with	with	ADP
gs-2738	49	14	epilepsy	epilepsy	NOUN
gs-2738	49	15	who	who	PRON
gs-2738	49	16	had	have	VERB
gs-2738	49	17	ongoing	ongoing	ADJ
gs-2738	49	18	long	long	ADJ
gs-2738	49	19	term	term	NOUN
gs-2738	49	20	follow	follow	NOUN
gs-2738	49	21	-	-	PUNCT
gs-2738	49	22	up	up	NOUN
gs-2738	49	23	and	and	CCONJ
gs-2738	49	24	healthy	healthy	ADJ
gs-2738	49	25	control	control	NOUN
gs-2738	49	26	group	group	NOUN
gs-2738	49	27	,	,	PUNCT
gs-2738	49	28	in	in	ADP
gs-2738	49	29	total	total	ADJ
gs-2738	49	30	56	56	NUM
gs-2738	49	31	patients	patient	NOUN
gs-2738	49	32	aged	age	VERB
gs-2738	49	33	0–16	0–16	NOUN
gs-2738	50	1	[	[	X
gs-2738	50	2	20	20	NUM
gs-2738	50	3	]	]	PUNCT
gs-2738	50	4	,	,	PUNCT
gs-2738	50	5	were	be	AUX
gs-2738	50	6	selected	select	VERB
gs-2738	50	7	for	for	ADP
gs-2738	50	8	study	study	NOUN
gs-2738	50	9	groups-	groups-	NOUN
gs-2738	50	10	:	:	PUNCT
gs-2738	50	11	patients	patient	NOUN
gs-2738	50	12	diagnosed	diagnose	VERB
gs-2738	50	13	with	with	ADP
gs-2738	50	14	epilepsy	epilepsy	ADJ
gs-2738	50	15	-seizure	-seizure	NOUN
gs-2738	50	16	-	-	PUNCT
gs-2738	50	17	free	free	ADJ
gs-2738	50	18	on	on	ADP
gs-2738	50	19	aed	aed	NOUN
gs-2738	50	20	therapy	therapy	NOUN
gs-2738	50	21	n=20	n=20	PROPN
gs-2738	50	22	,	,	PUNCT
gs-2738	50	23	refractory	refractory	NOUN
gs-2738	50	24	epilepsy	epilepsy	NOUN
gs-2738	50	25	patients	patient	NOUN
gs-2738	50	26	n=20	n=20	NOUN
gs-2738	50	27	,	,	PUNCT
gs-2738	50	28	and	and	CCONJ
gs-2738	50	29	healthy	healthy	ADJ
gs-2738	50	30	controls	control	NOUN
gs-2738	50	31	n=16	n=16	NOUN
gs-2738	50	32	.	.	PUNCT
gs-2738	51	1	amongst	amongst	ADP
gs-2738	51	2	40	40	NUM
gs-2738	51	3	patients	patient	NOUN
gs-2738	51	4	with	with	ADP
gs-2738	51	5	epilepsy	epilepsy	NOUN
gs-2738	51	6	,	,	PUNCT
gs-2738	51	7	mean	mean	VERB
gs-2738	51	8	follow	follow	VERB
gs-2738	51	9	-	-	PUNCT
gs-2738	51	10	up	up	ADP
gs-2738	51	11	duration	duration	NOUN
gs-2738	51	12	18.5(range	18.5(range	NUM
gs-2738	51	13	1124	1124	NUM
gs-2738	51	14	)	)	PUNCT
gs-2738	51	15	months	month	NOUN
gs-2738	51	16	with	with	ADP
gs-2738	51	17	11	11	NUM
gs-2738	51	18	being	be	AUX
gs-2738	51	19	refractory	refractory	NOUN
gs-2738	51	20	over	over	ADP
gs-2738	51	21	mean	mean	NOUN
gs-2738	51	22	of	of	ADP
gs-2738	51	23	5.6	5.6	NUM
gs-2738	51	24	(	(	PUNCT
gs-2738	51	25	range	range	VERB
gs-2738	51	26	0.92	0.92	NUM
gs-2738	51	27	-	-	SYM
gs-2738	51	28	14)years	14)years	NUM
gs-2738	51	29	[	[	PUNCT
gs-2738	51	30	7	7	NUM
gs-2738	51	31	females	female	NOUN
gs-2738	51	32	;	;	PUNCT
gs-2738	51	33	mean	mean	VERB
gs-2738	51	34	8.3(range	8.3(range	NUM
gs-2738	51	35	4	4	NUM
gs-2738	51	36	-	-	SYM
gs-2738	51	37	11)years	11)years	NUM
gs-2738	51	38	;	;	PUNCT
gs-2738	51	39	4	4	NUM
gs-2738	51	40	having	having	AUX
gs-2738	51	41	at	at	ADV
gs-2738	51	42	least	least	ADJ
gs-2738	51	43	seizure	seizure	VERB
gs-2738	51	44	free	free	ADJ
gs-2738	51	45	periods	period	NOUN
gs-2738	51	46	[	[	X
gs-2738	51	47	2	2	NUM
gs-2738	51	48	females	female	NOUN
gs-2738	51	49	;	;	PUNCT
gs-2738	51	50	mean	mean	VERB
gs-2738	51	51	10.5(range	10.5(range	NUM
gs-2738	51	52	7	7	NUM
gs-2738	51	53	-	-	SYM
gs-2738	51	54	14)years	14)years	NUM
gs-2738	51	55	;	;	PUNCT
gs-2738	51	56	mean	mean	ADJ
gs-2738	51	57	time	time	NOUN
gs-2738	51	58	12.2(range	12.2(range	NUM
gs-2738	51	59	8	8	NUM
gs-2738	51	60	-	-	PUNCT
gs-2738	51	61	120)months	120)months	NUM
gs-2738	51	62	.	.	PUNCT
gs-2738	52	1	both	both	CCONJ
gs-2738	52	2	pharmacosensitive	pharmacosensitive	ADJ
gs-2738	52	3	and	and	CCONJ
gs-2738	52	4	refractory	refractory	NOUN
gs-2738	52	5	groups	group	NOUN
gs-2738	52	6	did	do	AUX
gs-2738	52	7	not	not	PART
gs-2738	52	8	differ	differ	VERB
gs-2738	52	9	on	on	ADP
gs-2738	52	10	seizure	seizure	NOUN
gs-2738	52	11	semiology	semiology	NOUN
gs-2738	52	12	neither	neither	CCONJ
gs-2738	52	13	clinically	clinically	ADV
gs-2738	52	14	,	,	PUNCT
gs-2738	52	15	based	base	VERB
gs-2738	52	16	on	on	ADP
gs-2738	52	17	eeg	eeg	NOUN
gs-2738	52	18	or	or	CCONJ
gs-2738	52	19	radiology	radiology	NOUN
gs-2738	52	20	.	.	PUNCT
gs-2738	53	1	refractory	refractory	NOUN
gs-2738	53	2	group	group	NOUN
gs-2738	53	3	had	have	AUX
gs-2738	53	4	mean	mean	VERB
gs-2738	53	5	15.7	15.7	NUM
gs-2738	53	6	±	±	NUM
gs-2738	53	7	2.25	2.25	NUM
gs-2738	53	8	seizures	seizure	NOUN
gs-2738	53	9	.	.	PUNCT
gs-2738	54	1	pharmacosensitive	pharmacosensitive	ADJ
gs-2738	54	2	group	group	NOUN
gs-2738	54	3	had	have	VERB
gs-2738	54	4	a	a	DET
gs-2738	54	5	mean	mean	NOUN
gs-2738	54	6	of	of	ADP
gs-2738	54	7	2.9±	2.9±	PROPN
gs-2738	54	8	0.59	0.59	NUM
gs-2738	54	9	seizures	seizure	NOUN
gs-2738	54	10	.	.	PUNCT
gs-2738	55	1	demographics	demographic	NOUN
gs-2738	55	2	and	and	CCONJ
gs-2738	55	3	clinical	clinical	ADJ
gs-2738	55	4	characteristics	characteristic	NOUN
gs-2738	55	5	of	of	ADP
gs-2738	55	6	cohort	cohort	NOUN
gs-2738	55	7	is	be	AUX
gs-2738	55	8	shortly	shortly	ADV
gs-2738	55	9	outlined	outline	VERB
gs-2738	55	10	in	in	ADP
gs-2738	55	11	table	table	NOUN
gs-2738	55	12	1	1	NUM
gs-2738	55	13	.	.	PUNCT
gs-2738	55	14	table	table	NOUN
gs-2738	55	15	1	1	NUM
gs-2738	55	16	:	:	PUNCT
gs-2738	55	17	demographics	demographic	NOUN
gs-2738	55	18	and	and	CCONJ
gs-2738	55	19	clinical	clinical	ADJ
gs-2738	55	20	characteristics	characteristic	NOUN
gs-2738	55	21	group	group	NOUN
gs-2738	55	22	1	1	NUM
gs-2738	55	23	group	group	NOUN
gs-2738	55	24	2a	2a	NUM
gs-2738	55	25	group	group	PROPN
gs-2738	55	26	2b	2b	NUM
gs-2738	55	27	va	va	PROPN
gs-2738	55	28	responders	responder	NOUN
gs-2738	55	29	va	va	PROPN
gs-2738	55	30	non	non	NOUN
gs-2738	55	31	-	-	NOUN
gs-2738	55	32	responders	responder	NOUN
gs-2738	55	33	n	n	NOUN
gs-2738	55	34	16	16	NUM
gs-2738	55	35	20	20	NUM
gs-2738	55	36	20	20	NUM
gs-2738	55	37	11	11	NUM
gs-2738	55	38	14	14	NUM
gs-2738	55	39	male	male	ADJ
gs-2738	55	40	/	/	SYM
gs-2738	55	41	female	female	ADJ
gs-2738	55	42	ratio	ratio	NOUN
gs-2738	55	43	8/8	8/8	NUM
gs-2738	55	44	12/8	12/8	NUM
gs-2738	55	45	9/11	9/11	NUM
gs-2738	55	46	7/4	7/4	NUM
gs-2738	55	47	9/5	9/5	NUM
gs-2738	55	48	age	age	NOUN
gs-2738	55	49	(	(	PUNCT
gs-2738	55	50	mean	mean	NOUN
gs-2738	55	51	+	+	NUM
gs-2738	55	52	sd	sd	NUM
gs-2738	55	53	years	year	NOUN
gs-2738	55	54	)	)	PUNCT
gs-2738	55	55	9.2	9.2	NUM
gs-2738	56	1	+	+	NUM
gs-2738	56	2	4.0	4.0	NUM
gs-2738	56	3	8.5	8.5	NUM
gs-2738	56	4	+	+	NOUN
gs-2738	56	5	4.6	4.6	NUM
gs-2738	56	6	9.2	9.2	NUM
gs-2738	56	7	+	+	NUM
gs-2738	56	8	4.2	4.2	NUM
gs-2738	56	9	7.1	7.1	NUM
gs-2738	56	10	+	+	NOUN
gs-2738	56	11	3.2	3.2	NUM
gs-2738	56	12	6.2	6.2	NUM
gs-2738	56	13	+	+	SYM
gs-2738	56	14	4.2	4.2	NUM
gs-2738	56	15	mean	mean	ADJ
gs-2738	56	16	(	(	PUNCT
gs-2738	56	17	iqr	iqr	NOUN
gs-2738	56	18	)	)	PUNCT
gs-2738	56	19	follow	follow	VERB
gs-2738	56	20	-	-	PUNCT
gs-2738	56	21	up	up	ADP
gs-2738	56	22	duration	duration	NOUN
gs-2738	56	23	(	(	PUNCT
gs-2738	56	24	months	month	NOUN
gs-2738	56	25	)	)	PUNCT
gs-2738	56	26	16.7	16.7	NUM
gs-2738	56	27	(	(	PUNCT
gs-2738	56	28	2.5	2.5	NUM
gs-2738	56	29	–	–	PUNCT
gs-2738	56	30	22.3	22.3	NUM
gs-2738	56	31	)	)	PUNCT
gs-2738	56	32	18.1	18.1	NUM
gs-2738	56	33	(	(	PUNCT
gs-2738	56	34	3.220.5	3.220.5	NUM
gs-2738	56	35	)	)	PUNCT
gs-2738	56	36	19.2	19.2	NUM
gs-2738	56	37	(	(	PUNCT
gs-2738	56	38	8.2	8.2	NUM
gs-2738	56	39	-	-	SYM
gs-2738	56	40	24	24	NUM
gs-2738	56	41	)	)	PUNCT
gs-2738	56	42	14.0	14.0	NUM
gs-2738	56	43	(	(	PUNCT
gs-2738	56	44	7.0–17.0	7.0–17.0	NUM
gs-2738	56	45	)	)	PUNCT
gs-2738	56	46	georgian	georgian	ADJ
gs-2738	56	47	scientists/ქართველი	scientists/ქართველი	NOUN
gs-2738	56	48	მეცნიერები	მეცნიერები	NOUN
gs-2738	56	49	ტ.	ტ.	VERB
gs-2738	56	50	6	6	NUM
gs-2738	56	51	n	n	NUM
gs-2738	56	52	1	1	NUM
gs-2738	56	53	,	,	PUNCT
gs-2738	56	54	2024	2024	NUM
gs-2738	56	55	293	293	NUM
gs-2738	56	56	n	n	CCONJ
gs-2738	56	57	:	:	PUNCT
gs-2738	56	58	number	number	NOUN
gs-2738	56	59	of	of	ADP
gs-2738	56	60	samples	sample	NOUN
gs-2738	56	61	;	;	PUNCT
gs-2738	56	62	iqr	iqr	NOUN
gs-2738	56	63	:	:	PUNCT
gs-2738	56	64	interquartile	interquartile	ADJ
gs-2738	56	65	range	range	NOUN
gs-2738	56	66	;	;	PUNCT
gs-2738	56	67	bmi	bmi	PROPN
gs-2738	56	68	:	:	PUNCT
gs-2738	56	69	body	body	NOUN
gs-2738	56	70	mass	mass	PROPN
gs-2738	56	71	index	index	NOUN
gs-2738	56	72	;	;	PUNCT
gs-2738	56	73	va	va	NOUN
gs-2738	56	74	:	:	PUNCT
gs-2738	56	75	valproate	valproate	ADJ
gs-2738	56	76	.	.	PUNCT
gs-2738	57	1	mean	mean	ADJ
gs-2738	57	2	number	number	NOUN
gs-2738	57	3	of	of	ADP
gs-2738	57	4	medications	medication	NOUN
gs-2738	57	5	prior	prior	ADV
gs-2738	57	6	to	to	ADP
gs-2738	57	7	becoming	become	VERB
gs-2738	57	8	refractory	refractory	NOUN
gs-2738	57	9	was	be	AUX
gs-2738	57	10	3	3	NUM
gs-2738	57	11	(	(	PUNCT
gs-2738	57	12	range	range	NOUN
gs-2738	57	13	2	2	NUM
gs-2738	57	14	-	-	SYM
gs-2738	57	15	5	5	NUM
gs-2738	57	16	)	)	PUNCT
gs-2738	57	17	.	.	PUNCT
gs-2738	58	1	all	all	DET
gs-2738	58	2	the	the	DET
gs-2738	58	3	patients	patient	NOUN
gs-2738	58	4	were	be	AUX
gs-2738	58	5	treated	treat	VERB
gs-2738	58	6	by	by	ADP
gs-2738	58	7	different	different	ADJ
gs-2738	58	8	aed	aed	NOUN
gs-2738	58	9	were	be	AUX
gs-2738	58	10	segregated	segregate	VERB
gs-2738	58	11	on	on	ADP
gs-2738	58	12	the	the	DET
gs-2738	58	13	basis	basis	NOUN
gs-2738	58	14	of	of	ADP
gs-2738	58	15	drug	drug	NOUN
gs-2738	58	16	.	.	PUNCT
gs-2738	59	1	valproic	valproic	ADJ
gs-2738	59	2	acid	acid	NOUN
gs-2738	59	3	was	be	AUX
gs-2738	59	4	included	include	VERB
gs-2738	59	5	in	in	ADP
gs-2738	59	6	therapies	therapy	NOUN
gs-2738	59	7	of	of	ADP
gs-2738	59	8	14/20	14/20	NUM
gs-2738	59	9	resistant	resistant	ADJ
gs-2738	59	10	group	group	NOUN
gs-2738	59	11	and	and	CCONJ
gs-2738	59	12	11/20	11/20	NUM
gs-2738	59	13	patients	patient	NOUN
gs-2738	59	14	of	of	ADP
gs-2738	59	15	controlled	control	VERB
gs-2738	59	16	epilepsy	epilepsy	NOUN
gs-2738	59	17	group	group	NOUN
gs-2738	59	18	.	.	PUNCT
gs-2738	60	1	overall	overall	ADJ
gs-2738	60	2	,	,	PUNCT
gs-2738	60	3	53	53	NUM
gs-2738	60	4	%	%	NOUN
gs-2738	60	5	(	(	PUNCT
gs-2738	60	6	21/40	21/40	NUM
gs-2738	60	7	)	)	PUNCT
gs-2738	60	8	patients	patient	NOUN
gs-2738	60	9	each	each	PRON
gs-2738	60	10	from	from	ADP
gs-2738	60	11	pharmacosensitive	pharmacosensitive	NOUN
gs-2738	60	12	and	and	CCONJ
gs-2738	60	13	refractory	refractory	NOUN
gs-2738	60	14	were	be	AUX
gs-2738	60	15	on	on	ADP
gs-2738	60	16	combination	combination	NOUN
gs-2738	60	17	therapy	therapy	NOUN
gs-2738	60	18	of	of	ADP
gs-2738	60	19	two	two	NUM
gs-2738	60	20	aeds	aed	NOUN
gs-2738	60	21	.	.	PUNCT
gs-2738	61	1	our	our	PRON
gs-2738	61	2	patients	patient	NOUN
gs-2738	61	3	did	do	AUX
gs-2738	61	4	not	not	PART
gs-2738	61	5	receive	receive	VERB
gs-2738	61	6	treatment	treatment	NOUN
gs-2738	61	7	involving	involve	VERB
gs-2738	61	8	a	a	DET
gs-2738	61	9	ketogenic	ketogenic	ADJ
gs-2738	61	10	diet	diet	NOUN
gs-2738	61	11	or	or	CCONJ
gs-2738	61	12	a	a	DET
gs-2738	61	13	vagus	vagus	ADJ
gs-2738	61	14	nerve	nerve	NOUN
gs-2738	61	15	stimulator	stimulator	NOUN
gs-2738	61	16	.	.	PUNCT
gs-2738	62	1	measured	measure	VERB
gs-2738	62	2	serum	serum	NOUN
gs-2738	62	3	pge2	pge2	NOUN
gs-2738	62	4	the	the	DET
gs-2738	62	5	median	median	PROPN
gs-2738	62	6	interquartile	interquartile	NOUN
gs-2738	62	7	ranges	range	VERB
gs-2738	62	8	(	(	PUNCT
gs-2738	62	9	iqr	iqr	NOUN
gs-2738	62	10	)	)	PUNCT
gs-2738	62	11	were	be	AUX
gs-2738	62	12	higher	high	ADJ
gs-2738	62	13	and	and	CCONJ
gs-2738	62	14	in	in	ADP
gs-2738	62	15	broader	broad	ADJ
gs-2738	62	16	ranges	range	NOUN
gs-2738	62	17	for	for	ADP
gs-2738	62	18	epilepsy	epilepsy	NOUN
gs-2738	62	19	patients	patient	NOUN
gs-2738	62	20	all	all	ADV
gs-2738	62	21	together	together	ADV
gs-2738	62	22	512	512	NUM
gs-2738	62	23	pg	pg	NOUN
gs-2738	62	24	/	/	SYM
gs-2738	62	25	ml	ml	PROPN
gs-2738	62	26	(	(	PUNCT
gs-2738	62	27	324.5	324.5	NUM
gs-2738	62	28	-	-	SYM
gs-2738	62	29	970.0	970.0	NUM
gs-2738	62	30	)	)	PUNCT
gs-2738	62	31	compared	compare	VERB
gs-2738	62	32	to	to	ADP
gs-2738	62	33	healthy	healthy	ADJ
gs-2738	62	34	controls	control	NOUN
gs-2738	62	35	406	406	NUM
gs-2738	62	36	pg	pg	NOUN
gs-2738	62	37	/	/	SYM
gs-2738	62	38	ml	ml	PROPN
gs-2738	62	39	(	(	PUNCT
gs-2738	62	40	278.7541.4	278.7541.4	NUM
gs-2738	62	41	)	)	PUNCT
gs-2738	62	42	,	,	PUNCT
gs-2738	62	43	but	but	CCONJ
gs-2738	62	44	not	not	PART
gs-2738	62	45	significantly	significantly	ADV
gs-2738	62	46	different	different	ADJ
gs-2738	62	47	across	across	ADP
gs-2738	62	48	the	the	DET
gs-2738	62	49	epilepsy	epilepsy	NOUN
gs-2738	62	50	study	study	NOUN
gs-2738	62	51	groups	group	NOUN
gs-2738	62	52	(	(	PUNCT
gs-2738	62	53	p>0.05	p>0.05	PROPN
gs-2738	62	54	)	)	PUNCT
gs-2738	62	55	.	.	PUNCT
gs-2738	63	1	bmi	bmi	PROPN
gs-2738	63	2	(	(	PUNCT
gs-2738	63	3	kg	kg	NOUN
gs-2738	63	4	/	/	SYM
gs-2738	63	5	m2	m2	PROPN
gs-2738	63	6	)	)	PUNCT
gs-2738	63	7	,	,	PUNCT
gs-2738	63	8	median	median	NOUN
gs-2738	63	9	(	(	PUNCT
gs-2738	63	10	iqr	iqr	NOUN
gs-2738	63	11	)	)	PUNCT
gs-2738	63	12	seizure	seizure	NOUN
gs-2738	63	13	type	type	NOUN
gs-2738	63	14	(	(	PUNCT
gs-2738	63	15	n	n	CCONJ
gs-2738	63	16	)	)	PUNCT
gs-2738	63	17	22.0	22.0	NUM
gs-2738	63	18	(	(	PUNCT
gs-2738	63	19	19.2	19.2	NUM
gs-2738	63	20	–	–	PUNCT
gs-2738	63	21	26.4	26.4	NUM
gs-2738	63	22	)	)	PUNCT
gs-2738	63	23	20.9	20.9	NUM
gs-2738	63	24	(	(	PUNCT
gs-2738	63	25	19.6	19.6	NUM
gs-2738	63	26	–	–	SYM
gs-2738	63	27	22.7	22.7	NUM
gs-2738	63	28	)	)	PUNCT
gs-2738	63	29	20.5	20.5	NUM
gs-2738	63	30	(	(	PUNCT
gs-2738	63	31	18.6	18.6	NUM
gs-2738	63	32	–	–	PUNCT
gs-2738	63	33	24.7	24.7	NUM
gs-2738	63	34	)	)	PUNCT
gs-2738	63	35	20.3	20.3	NUM
gs-2738	63	36	(	(	PUNCT
gs-2738	63	37	18.9–26.7	18.9–26.7	NUM
gs-2738	63	38	)	)	PUNCT
gs-2738	63	39	19.2	19.2	NUM
gs-2738	63	40	(	(	PUNCT
gs-2738	63	41	18.0–22.1	18.0–22.1	NUM
gs-2738	63	42	)	)	PUNCT
gs-2738	63	43	focal	focal	ADJ
gs-2738	63	44	4	4	NUM
gs-2738	63	45	2	2	NUM
gs-2738	63	46	–	–	PUNCT
gs-2738	63	47	generalized	generalize	VERB
gs-2738	63	48	16	16	NUM
gs-2738	63	49	18	18	NUM
gs-2738	63	50	10	10	NUM
gs-2738	63	51	14	14	NUM
gs-2738	63	52	epilepsy	epilepsy	NOUN
gs-2738	63	53	type	type	NOUN
gs-2738	63	54	(	(	PUNCT
gs-2738	63	55	n	n	CCONJ
gs-2738	63	56	)	)	PUNCT
gs-2738	63	57	idiopathic	idiopathic	ADJ
gs-2738	63	58	epilepsy	epilepsy	NOUN
gs-2738	63	59	14	14	NUM
gs-2738	63	60	15	15	NUM
gs-2738	63	61	11	11	NUM
gs-2738	63	62	12	12	NUM
gs-2738	63	63	symptomatic	symptomatic	ADJ
gs-2738	63	64	epilepsy	epilepsy	NOUN
gs-2738	63	65	1	1	NUM
gs-2738	63	66	3	3	NUM
gs-2738	63	67	–	–	PUNCT
gs-2738	63	68	drug	drug	NOUN
gs-2738	63	69	dose	dose	NOUN
gs-2738	63	70	[	[	X
gs-2738	63	71	mg	mg	PROPN
gs-2738	63	72	/	/	SYM
gs-2738	63	73	day	day	NOUN
gs-2738	63	74	]	]	X
gs-2738	63	75	median	median	NOUN
gs-2738	63	76	(	(	PUNCT
gs-2738	63	77	iqr	iqr	NOUN
gs-2738	63	78	)	)	PUNCT
gs-2738	63	79	145	145	NUM
gs-2738	63	80	(	(	PUNCT
gs-2738	63	81	250	250	NUM
gs-2738	63	82	–	–	SYM
gs-2738	63	83	300	300	NUM
gs-2738	63	84	)	)	PUNCT
gs-2738	63	85	250	250	NUM
gs-2738	63	86	(	(	PUNCT
gs-2738	63	87	200	200	NUM
gs-2738	63	88	–	–	SYM
gs-2738	63	89	275	275	NUM
gs-2738	63	90	)	)	PUNCT
gs-2738	63	91	300	300	NUM
gs-2738	63	92	(	(	PUNCT
gs-2738	63	93	200–500	200–500	NUM
gs-2738	63	94	)	)	PUNCT
gs-2738	63	95	dosage	dosage	NOUN
gs-2738	63	96	[	[	X
gs-2738	63	97	(	(	PUNCT
gs-2738	63	98	mg	mg	PROPN
gs-2738	63	99	/	/	SYM
gs-2738	63	100	day)/kg	day)/kg	PROPN
gs-2738	63	101	]	]	X
gs-2738	63	102	22,2	22,2	PROPN
gs-2738	63	103	(	(	PUNCT
gs-2738	63	104	20.3	20.3	NUM
gs-2738	63	105	–	–	SYM
gs-2738	63	106	27.9	27.9	NUM
gs-2738	63	107	)	)	PUNCT
gs-2738	63	108	29.9	29.9	NUM
gs-2738	63	109	(	(	PUNCT
gs-2738	63	110	25	25	NUM
gs-2738	63	111	–	–	PUNCT
gs-2738	63	112	35,6	35,6	NOUN
gs-2738	63	113	)	)	PUNCT
gs-2738	63	114	33.1	33.1	NUM
gs-2738	63	115	(	(	PUNCT
gs-2738	63	116	30–36,7	30–36,7	NOUN
gs-2738	63	117	)	)	PUNCT
gs-2738	63	118	33.8	33.8	NUM
gs-2738	63	119	(	(	PUNCT
gs-2738	63	120	33.3–36.2	33.3–36.2	NUM
gs-2738	63	121	)	)	PUNCT
gs-2738	63	122	georgian	georgian	ADJ
gs-2738	63	123	scientists/ქართველი	scientists/ქართველი	NOUN
gs-2738	63	124	მეცნიერები	მეცნიერები	NOUN
gs-2738	63	125	ტ.	ტ.	VERB
gs-2738	63	126	6	6	NUM
gs-2738	64	1	n	n	NUM
gs-2738	64	2	1	1	NUM
gs-2738	64	3	,	,	PUNCT
gs-2738	64	4	2024	2024	NUM
gs-2738	64	5	294	294	NUM
gs-2738	64	6	figure	figure	NOUN
gs-2738	64	7	1	1	NUM
gs-2738	64	8	.	.	PUNCT
gs-2738	64	9	comparison	comparison	NOUN
gs-2738	64	10	of	of	ADP
gs-2738	64	11	plasma	plasma	NOUN
gs-2738	64	12	pge2	pge2	NOUN
gs-2738	64	13	levels	level	NOUN
gs-2738	64	14	a.	a.	NOUN
gs-2738	64	15	“	"	PUNCT
gs-2738	64	16	healthy	healthy	ADJ
gs-2738	64	17	controls	control	NOUN
gs-2738	64	18	”	"	PUNCT
gs-2738	64	19	vs	vs	ADP
gs-2738	64	20	all	all	PRON
gs-2738	64	21	diagnosed	diagnose	VERB
gs-2738	64	22	with	with	ADP
gs-2738	64	23	epilepsy	epilepsy	NOUN
gs-2738	64	24	;	;	PUNCT
gs-2738	64	25	b.	b.	X
gs-2738	64	26	“	"	PUNCT
gs-2738	64	27	healthy	healthy	ADJ
gs-2738	64	28	controls	control	NOUN
gs-2738	64	29	”	"	PUNCT
gs-2738	64	30	vs	vs	ADP
gs-2738	64	31	all	all	PRON
gs-2738	64	32	diagnosed	diagnose	VERB
gs-2738	64	33	with	with	ADP
gs-2738	64	34	epilepsy	epilepsy	NOUN
gs-2738	64	35	;	;	PUNCT
gs-2738	64	36	and	and	CCONJ
gs-2738	64	37	valproate	valproate	ADJ
gs-2738	64	38	responsiveness	responsiveness	NOUN
gs-2738	64	39	subtypes	subtype	NOUN
gs-2738	64	40	–	–	PUNCT
gs-2738	64	41	va	va	NOUN
gs-2738	64	42	responders	responder	NOUN
gs-2738	64	43	,	,	PUNCT
gs-2738	64	44	va	va	PROPN
gs-2738	64	45	non	non	NOUN
gs-2738	64	46	-	-	NOUN
gs-2738	64	47	responders	responder	NOUN
gs-2738	64	48	.	.	PUNCT
gs-2738	65	1	despite	despite	SCONJ
gs-2738	65	2	this	this	DET
gs-2738	65	3	valproate	valproate	ADJ
gs-2738	65	4	responders	responder	NOUN
gs-2738	65	5	showed	show	VERB
gs-2738	65	6	reduced	reduced	ADJ
gs-2738	65	7	pge2	pge2	NOUN
gs-2738	65	8	mean	mean	PROPN
gs-2738	65	9	iqr	iqr	PROPN
gs-2738	65	10	490	490	NUM
gs-2738	65	11	pg	pg	NOUN
gs-2738	65	12	/	/	SYM
gs-2738	65	13	ml	ml	X
gs-2738	65	14	in	in	ADP
gs-2738	65	15	comparison	comparison	NOUN
gs-2738	65	16	to	to	PART
gs-2738	65	17	valproate	valproate	VERB
gs-2738	65	18	non	non	ADJ
gs-2738	65	19	-	-	NOUN
gs-2738	65	20	responders	responder	NOUN
gs-2738	65	21	group	group	NOUN
gs-2738	65	22	.	.	PUNCT
gs-2738	66	1	corresponding	correspond	VERB
gs-2738	66	2	data	datum	NOUN
gs-2738	66	3	are	be	AUX
gs-2738	66	4	given	give	VERB
gs-2738	66	5	in	in	ADP
gs-2738	66	6	table	table	NOUN
gs-2738	66	7	2	2	NUM
gs-2738	66	8	.	.	PUNCT
gs-2738	66	9	table	table	NOUN
gs-2738	66	10	2	2	NUM
gs-2738	66	11	:	:	PUNCT
gs-2738	66	12	plasma	plasma	NOUN
gs-2738	66	13	pge2	pge2	NOUN
gs-2738	66	14	levels	level	NOUN
gs-2738	66	15	in	in	ADP
gs-2738	66	16	study	study	NOUN
gs-2738	66	17	groups	group	NOUN
gs-2738	66	18	:	:	PUNCT
gs-2738	66	19	sample	sample	NOUN
gs-2738	66	20	groups	group	NOUN
gs-2738	66	21	iqr	iqr	PROPN
gs-2738	66	22	drug	drug	PROPN
gs-2738	66	23	resistant	resistant	ADJ
gs-2738	66	24	pharmacosensitive	pharmacosensitive	ADJ
gs-2738	66	25	healthy	healthy	ADJ
gs-2738	66	26	controls	control	NOUN
gs-2738	66	27	va	va	PROPN
gs-2738	66	28	responders	responder	NOUN
gs-2738	66	29	va	va	PROPN
gs-2738	66	30	nonresponders	nonresponder	NOUN
gs-2738	66	31	pge2	pge2	PROPN
gs-2738	66	32	q1	q1	PROPN
gs-2738	66	33	324.2	324.2	NUM
gs-2738	66	34	388.0	388.0	NUM
gs-2738	66	35	278.0	278.0	NUM
gs-2738	66	36	240	240	NUM
gs-2738	66	37	256	256	NUM
gs-2738	66	38	q2	q2	NOUN
gs-2738	66	39	549.5	549.5	NUM
gs-2738	66	40	475.0	475.0	NUM
gs-2738	66	41	406.0	406.0	NUM
gs-2738	66	42	490	490	NUM
gs-2738	66	43	653	653	NUM
gs-2738	66	44	q3	q3	NOUN
gs-2738	66	45	970.0	970.0	NUM
gs-2738	66	46	595.0	595.0	NUM
gs-2738	66	47	541.0	541.0	NUM
gs-2738	66	48	820	820	NUM
gs-2738	66	49	970	970	NUM
gs-2738	66	50	iqr	iqr	PROPN
gs-2738	66	51	:	:	PUNCT
gs-2738	66	52	interquartile	interquartile	NOUN
gs-2738	66	53	range	range	NOUN
gs-2738	66	54	;	;	PUNCT
gs-2738	66	55	va	va	NOUN
gs-2738	66	56	:	:	PUNCT
gs-2738	66	57	valproate	valproate	ADJ
gs-2738	66	58	.	.	PUNCT
gs-2738	67	1	discussion	discussion	NOUN
gs-2738	67	2	recent	recent	ADJ
gs-2738	67	3	studies	study	NOUN
gs-2738	67	4	by	by	ADP
gs-2738	67	5	vezzani	vezzani	NOUN
gs-2738	67	6	et	et	PROPN
gs-2738	67	7	al	al	PROPN
gs-2738	67	8	.	.	PROPN
gs-2738	67	9	have	have	AUX
gs-2738	67	10	shown	show	VERB
gs-2738	67	11	an	an	DET
gs-2738	67	12	imbalance	imbalance	NOUN
gs-2738	67	13	in	in	ADP
gs-2738	67	14	cytokine	cytokine	ADJ
gs-2738	67	15	levels	level	NOUN
gs-2738	67	16	in	in	ADP
gs-2738	67	17	epileptic	epileptic	ADJ
gs-2738	67	18	tissues	tissue	NOUN
gs-2738	67	19	,	,	PUNCT
gs-2738	67	20	indicating	indicate	VERB
gs-2738	67	21	a	a	DET
gs-2738	67	22	connection	connection	NOUN
gs-2738	67	23	between	between	ADP
gs-2738	67	24	epilepsy	epilepsy	NOUN
gs-2738	67	25	and	and	CCONJ
gs-2738	67	26	inflammatory	inflammatory	ADJ
gs-2738	67	27	processes	process	NOUN
gs-2738	67	28	.	.	PUNCT
gs-2738	68	1	this	this	PRON
gs-2738	68	2	suggests	suggest	VERB
gs-2738	68	3	that	that	SCONJ
gs-2738	68	4	neuroinflammation	neuroinflammation	NOUN
gs-2738	68	5	may	may	AUX
gs-2738	68	6	disrupt	disrupt	VERB
gs-2738	68	7	mechanisms	mechanism	NOUN
gs-2738	68	8	of	of	ADP
gs-2738	68	9	epileptogenesis	epileptogenesis	NOUN
gs-2738	68	10	by	by	ADP
gs-2738	68	11	affecting	affect	VERB
gs-2738	68	12	seizure	seizure	NOUN
gs-2738	68	13	threshold	threshold	NOUN
gs-2738	68	14	and	and	CCONJ
gs-2738	68	15	blood	blood	NOUN
gs-2738	68	16	-	-	PUNCT
gs-2738	68	17	brain	brain	NOUN
gs-2738	68	18	barrier	barrier	NOUN
gs-2738	68	19	(	(	PUNCT
gs-2738	68	20	bbb	bbb	NOUN
gs-2738	68	21	)	)	PUNCT
gs-2738	68	22	function	function	NOUN
gs-2738	68	23	.	.	PUNCT
gs-2738	69	1	[	[	X
gs-2738	69	2	21	21	NUM
gs-2738	69	3	]	]	PUNCT
gs-2738	69	4	.	.	PUNCT
gs-2738	70	1	major	major	ADJ
gs-2738	70	2	inflammatory	inflammatory	ADJ
gs-2738	70	3	drivers	driver	NOUN
gs-2738	70	4	in	in	ADP
gs-2738	70	5	the	the	DET
gs-2738	70	6	brain	brain	NOUN
gs-2738	70	7	include	include	VERB
gs-2738	70	8	cox-2	cox-2	NOUN
gs-2738	70	9	,	,	PUNCT
gs-2738	70	10	il1β	il1β	PROPN
gs-2738	70	11	,	,	PUNCT
gs-2738	70	12	tnf	tnf	PROPN
gs-2738	70	13	-	-	PUNCT
gs-2738	70	14	α	α	PROPN
gs-2738	70	15	,	,	PUNCT
gs-2738	70	16	tgf	tgf	PROPN
gs-2738	70	17	-	-	PUNCT
gs-2738	70	18	β	β	PROPN
gs-2738	70	19	and	and	CCONJ
gs-2738	70	20	ccl2	ccl2	NOUN
gs-2738	71	1	[	[	X
gs-2738	71	2	22	22	NUM
gs-2738	71	3	]	]	PUNCT
gs-2738	71	4	.	.	PUNCT
gs-2738	72	1	in	in	ADP
gs-2738	72	2	epilepsy	epilepsy	NOUN
gs-2738	72	3	research	research	NOUN
gs-2738	72	4	,	,	PUNCT
gs-2738	72	5	inflammation	inflammation	NOUN
gs-2738	72	6	is	be	AUX
gs-2738	72	7	often	often	ADV
gs-2738	72	8	overlooked	overlook	VERB
gs-2738	72	9	despite	despite	SCONJ
gs-2738	72	10	its	its	PRON
gs-2738	72	11	potential	potential	ADJ
gs-2738	72	12	significance	significance	NOUN
gs-2738	72	13	.	.	PUNCT
gs-2738	73	1	to	to	PART
gs-2738	73	2	address	address	VERB
gs-2738	73	3	this	this	DET
gs-2738	73	4	gap	gap	NOUN
gs-2738	73	5	,	,	PUNCT
gs-2738	73	6	we	we	PRON
gs-2738	73	7	investigated	investigate	VERB
gs-2738	73	8	the	the	DET
gs-2738	73	9	role	role	NOUN
gs-2738	73	10	of	of	ADP
gs-2738	73	11	interictal	interictal	ADJ
gs-2738	73	12	pge2	pge2	NOUN
gs-2738	73	13	levels	level	NOUN
gs-2738	73	14	in	in	ADP
gs-2738	73	15	epilepsyassociated	epilepsyassociate	VERB
gs-2738	73	16	inflammation	inflammation	NOUN
gs-2738	73	17	and	and	CCONJ
gs-2738	73	18	drug	drug	NOUN
gs-2738	73	19	response	response	NOUN
gs-2738	73	20	.	.	PUNCT
gs-2738	74	1	our	our	PRON
gs-2738	74	2	study	study	NOUN
gs-2738	74	3	found	find	VERB
gs-2738	74	4	varying	vary	VERB
gs-2738	74	5	pge2	pge2	NOUN
gs-2738	74	6	levels	level	NOUN
gs-2738	74	7	across	across	ADP
gs-2738	74	8	different	different	ADJ
gs-2738	74	9	epilepsy	epilepsy	NOUN
gs-2738	74	10	groups	group	NOUN
gs-2738	74	11	,	,	PUNCT
gs-2738	74	12	with	with	ADP
gs-2738	74	13	refractory	refractory	NOUN
gs-2738	74	14	seizure	seizure	VERB
gs-2738	74	15	patients	patient	NOUN
gs-2738	74	16	showing	show	VERB
gs-2738	74	17	higher	high	ADJ
gs-2738	74	18	levels	level	NOUN
gs-2738	74	19	compared	compare	VERB
gs-2738	74	20	to	to	ADP
gs-2738	74	21	controlled	control	VERB
gs-2738	74	22	seizure	seizure	NOUN
gs-2738	74	23	patients	patient	NOUN
gs-2738	74	24	and	and	CCONJ
gs-2738	74	25	healthy	healthy	ADJ
gs-2738	74	26	controls	control	NOUN
gs-2738	74	27	.	.	PUNCT
gs-2738	75	1	interestingly	interestingly	ADV
gs-2738	75	2	,	,	PUNCT
gs-2738	75	3	valproate	valproate	ADJ
gs-2738	75	4	responders	responder	NOUN
gs-2738	75	5	exhibited	exhibit	VERB
gs-2738	75	6	lower	low	ADJ
gs-2738	75	7	pge2	pge2	NOUN
gs-2738	75	8	levels	level	NOUN
gs-2738	75	9	.	.	PUNCT
gs-2738	76	1	these	these	DET
gs-2738	76	2	findings	finding	NOUN
gs-2738	76	3	support	support	VERB
gs-2738	76	4	the	the	DET
gs-2738	76	5	idea	idea	NOUN
gs-2738	76	6	that	that	SCONJ
gs-2738	76	7	pge2	pge2	NOUN
gs-2738	76	8	could	could	AUX
gs-2738	76	9	be	be	AUX
gs-2738	76	10	a	a	DET
gs-2738	76	11	promising	promising	ADJ
gs-2738	76	12	target	target	NOUN
gs-2738	76	13	in	in	ADP
gs-2738	76	14	overcoming	overcome	VERB
gs-2738	76	15	drug	drug	NOUN
gs-2738	76	16	resistance	resistance	NOUN
gs-2738	76	17	,	,	PUNCT
gs-2738	76	18	aligning	align	VERB
gs-2738	76	19	with	with	ADP
gs-2738	76	20	preclinical	preclinical	ADJ
gs-2738	76	21	models	model	NOUN
gs-2738	76	22	.	.	PUNCT
gs-2738	77	1	georgian	georgian	ADJ
gs-2738	77	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-2738	77	3	მეცნიერები	მეცნიერები	NOUN
gs-2738	77	4	ტ.	ტ.	VERB
gs-2738	77	5	6	6	NUM
gs-2738	77	6	n	n	NUM
gs-2738	77	7	1	1	NUM
gs-2738	77	8	,	,	PUNCT
gs-2738	77	9	2024	2024	NUM
gs-2738	77	10	295	295	NUM
gs-2738	77	11	as	as	SCONJ
gs-2738	77	12	it	it	PRON
gs-2738	77	13	known	know	VERB
gs-2738	77	14	,	,	PUNCT
gs-2738	77	15	pge2	pge2	NOUN
gs-2738	77	16	is	be	AUX
gs-2738	77	17	an	an	DET
gs-2738	77	18	essential	essential	ADJ
gs-2738	77	19	pro	pro	ADJ
gs-2738	77	20	-	-	ADJ
gs-2738	77	21	inflammatory	inflammatory	ADJ
gs-2738	77	22	mediator	mediator	NOUN
gs-2738	77	23	of	of	ADP
gs-2738	77	24	cyclooxygenase	cyclooxygenase	NOUN
gs-2738	77	25	2	2	NUM
gs-2738	77	26	–	–	PUNCT
gs-2738	77	27	prostaglandin	prostaglandin	NOUN
gs-2738	77	28	e2	e2	NOUN
gs-2738	77	29	–	–	PUNCT
gs-2738	77	30	prostaglandin	prostaglandin	NOUN
gs-2738	77	31	e2	e2	NOUN
gs-2738	77	32	receptor	receptor	NOUN
gs-2738	77	33	1	1	NUM
gs-2738	77	34	axis	axis	NOUN
gs-2738	77	35	,	,	PUNCT
gs-2738	77	36	having	have	VERB
gs-2738	77	37	role	role	NOUN
gs-2738	77	38	in	in	ADP
gs-2738	77	39	neuroinflammation	neuroinflammation	NOUN
gs-2738	77	40	and	and	CCONJ
gs-2738	77	41	blood	blood	NOUN
gs-2738	77	42	-	-	PUNCT
gs-2738	77	43	brain	brain	NOUN
gs-2738	77	44	barrier	barrier	NOUN
gs-2738	77	45	dysfunction	dysfunction	NOUN
gs-2738	77	46	,	,	PUNCT
gs-2738	77	47	which	which	PRON
gs-2738	77	48	is	be	AUX
gs-2738	77	49	could	could	AUX
gs-2738	77	50	have	have	AUX
gs-2738	77	51	been	be	AUX
gs-2738	77	52	mechanisms	mechanism	NOUN
gs-2738	77	53	involved	involve	VERB
gs-2738	77	54	in	in	ADP
gs-2738	77	55	drug	drug	NOUN
gs-2738	77	56	resistance	resistance	NOUN
gs-2738	78	1	[	[	X
gs-2738	78	2	23	23	NUM
gs-2738	78	3	]	]	PUNCT
gs-2738	78	4	.	.	PUNCT
gs-2738	78	5	followed	follow	VERB
gs-2738	78	6	to	to	ADP
gs-2738	78	7	seizures	seizure	NOUN
gs-2738	78	8	pge2	pge2	NOUN
gs-2738	78	9	release	release	NOUN
gs-2738	78	10	related	related	ADJ
gs-2738	78	11	effects	effect	NOUN
gs-2738	78	12	has	have	AUX
gs-2738	78	13	been	be	AUX
gs-2738	78	14	discussed	discuss	VERB
gs-2738	78	15	in	in	ADP
gs-2738	78	16	many	many	ADJ
gs-2738	78	17	studies	study	NOUN
gs-2738	78	18	and	and	CCONJ
gs-2738	78	19	the	the	DET
gs-2738	78	20	levels	level	NOUN
gs-2738	78	21	of	of	ADP
gs-2738	78	22	pge2	pge2	NOUN
gs-2738	78	23	are	be	AUX
gs-2738	78	24	known	know	VERB
gs-2738	78	25	to	to	PART
gs-2738	78	26	elevate	elevate	VERB
gs-2738	78	27	throughout	throughout	ADP
gs-2738	78	28	the	the	DET
gs-2738	78	29	ongoing	ongoing	ADJ
gs-2738	78	30	seizures	seizure	NOUN
gs-2738	78	31	and	and	CCONJ
gs-2738	78	32	after[30	after[30	NOUN
gs-2738	78	33	]	]	X
gs-2738	78	34	.	.	PUNCT
gs-2738	79	1	a	a	DET
gs-2738	79	2	transitory	transitory	ADJ
gs-2738	79	3	blockade	blockade	NOUN
gs-2738	79	4	of	of	ADP
gs-2738	79	5	the	the	DET
gs-2738	79	6	ep2	ep2	PROPN
gs-2738	79	7	receptor	receptor	NOUN
gs-2738	79	8	in	in	ADP
gs-2738	79	9	several	several	ADJ
gs-2738	79	10	rodent	rodent	NOUN
gs-2738	79	11	models	model	NOUN
gs-2738	79	12	resulted	result	VERB
gs-2738	79	13	in	in	ADP
gs-2738	79	14	a	a	DET
gs-2738	79	15	reduction	reduction	NOUN
gs-2738	79	16	in	in	ADP
gs-2738	79	17	seizure	seizure	NOUN
gs-2738	79	18	-	-	PUNCT
gs-2738	79	19	induced	induced	ADJ
gs-2738	79	20	functional	functional	ADJ
gs-2738	79	21	deficits	deficit	NOUN
gs-2738	79	22	and	and	CCONJ
gs-2738	79	23	a	a	DET
gs-2738	79	24	decrease	decrease	NOUN
gs-2738	79	25	in	in	ADP
gs-2738	79	26	cytokine	cytokine	ADJ
gs-2738	79	27	production	production	NOUN
gs-2738	79	28	,	,	PUNCT
gs-2738	79	29	gliosis	gliosis	NOUN
gs-2738	79	30	,	,	PUNCT
gs-2738	79	31	and	and	CCONJ
gs-2738	79	32	bbb	bbb	NUM
gs-2738	79	33	disruption	disruption	NOUN
gs-2738	79	34	,	,	PUNCT
gs-2738	79	35	thereby	thereby	ADV
gs-2738	79	36	exhibiting	exhibit	VERB
gs-2738	79	37	antiinflammatory	antiinflammatory	NOUN
gs-2738	79	38	and	and	CCONJ
gs-2738	79	39	neuroprotective	neuroprotective	ADJ
gs-2738	79	40	effect	effect	NOUN
gs-2738	79	41	[	[	X
gs-2738	79	42	24	24	NUM
gs-2738	79	43	]	]	PUNCT
gs-2738	79	44	.	.	PUNCT
gs-2738	80	1	while	while	SCONJ
gs-2738	80	2	pge2	pge2	NOUN
gs-2738	80	3	is	be	AUX
gs-2738	80	4	not	not	PART
gs-2738	80	5	typically	typically	ADV
gs-2738	80	6	associated	associate	VERB
gs-2738	80	7	with	with	ADP
gs-2738	80	8	childhood	childhood	NOUN
gs-2738	80	9	epilepsies	epilepsy	NOUN
gs-2738	80	10	,	,	PUNCT
gs-2738	80	11	it	it	PRON
gs-2738	80	12	has	have	AUX
gs-2738	80	13	been	be	AUX
gs-2738	80	14	implicated	implicate	VERB
gs-2738	80	15	in	in	ADP
gs-2738	80	16	the	the	DET
gs-2738	80	17	pathophysiology	pathophysiology	NOUN
gs-2738	80	18	of	of	ADP
gs-2738	80	19	resistant	resistant	ADJ
gs-2738	80	20	seizures	seizure	NOUN
gs-2738	80	21	,	,	PUNCT
gs-2738	80	22	particularly	particularly	ADV
gs-2738	80	23	in	in	ADP
gs-2738	80	24	cases	case	NOUN
gs-2738	80	25	of	of	ADP
gs-2738	80	26	temporal	temporal	ADJ
gs-2738	80	27	lobe	lobe	NOUN
gs-2738	80	28	epilepsy	epilepsy	NOUN
gs-2738	80	29	(	(	PUNCT
gs-2738	80	30	tle),whereas	tle),wherea	NOUN
gs-2738	80	31	inflammatory	inflammatory	ADJ
gs-2738	80	32	processes	process	NOUN
gs-2738	80	33	have	have	AUX
gs-2738	80	34	been	be	AUX
gs-2738	80	35	identified	identify	VERB
gs-2738	80	36	as	as	ADP
gs-2738	80	37	potential	potential	ADJ
gs-2738	80	38	factors	factor	NOUN
gs-2738	80	39	contributing	contribute	VERB
gs-2738	80	40	to	to	ADP
gs-2738	80	41	the	the	DET
gs-2738	80	42	development	development	NOUN
gs-2738	80	43	and	and	CCONJ
gs-2738	80	44	maintenance	maintenance	NOUN
gs-2738	80	45	of	of	ADP
gs-2738	80	46	seizures	seizure	NOUN
gs-2738	81	1	[	[	X
gs-2738	81	2	25	25	NUM
gs-2738	81	3	]	]	PUNCT
gs-2738	81	4	.thus	.thus	CCONJ
gs-2738	81	5	our	our	PRON
gs-2738	81	6	results	result	NOUN
gs-2738	81	7	wide	wide	ADJ
gs-2738	81	8	range	range	NOUN
gs-2738	81	9	of	of	ADP
gs-2738	81	10	pge2	pge2	NOUN
gs-2738	81	11	levels	level	NOUN
gs-2738	81	12	in	in	ADP
gs-2738	81	13	refractrory	refractrory	NOUN
gs-2738	81	14	seizure	seizure	NOUN
gs-2738	81	15	group	group	NOUN
gs-2738	81	16	also	also	ADV
gs-2738	81	17	could	could	AUX
gs-2738	81	18	support	support	VERB
gs-2738	81	19	idea	idea	NOUN
gs-2738	81	20	of	of	ADP
gs-2738	81	21	involvement	involvement	NOUN
gs-2738	81	22	these	these	DET
gs-2738	81	23	processes	process	NOUN
gs-2738	81	24	in	in	ADP
gs-2738	81	25	mechanism	mechanism	NOUN
gs-2738	81	26	of	of	ADP
gs-2738	81	27	seizure	seizure	NOUN
gs-2738	81	28	refractoriness	refractoriness	NOUN
gs-2738	81	29	.	.	PUNCT
gs-2738	82	1	although	although	SCONJ
gs-2738	82	2	,	,	PUNCT
gs-2738	82	3	pge2	pge2	NOUN
gs-2738	82	4	profiles	profile	NOUN
gs-2738	82	5	of	of	ADP
gs-2738	82	6	patients	patient	NOUN
gs-2738	82	7	on	on	ADP
gs-2738	82	8	the	the	DET
gs-2738	82	9	basis	basis	NOUN
gs-2738	82	10	of	of	ADP
gs-2738	82	11	recieving	recieve	VERB
gs-2738	82	12	drug	drug	NOUN
gs-2738	82	13	and	and	CCONJ
gs-2738	82	14	responsiveness	responsiveness	NOUN
gs-2738	82	15	were	be	AUX
gs-2738	82	16	analyzed	analyze	VERB
gs-2738	82	17	,	,	PUNCT
gs-2738	82	18	aiming	aim	VERB
gs-2738	82	19	to	to	PART
gs-2738	82	20	assess	assess	VERB
gs-2738	82	21	possible	possible	ADJ
gs-2738	82	22	link	link	NOUN
gs-2738	82	23	with	with	ADP
gs-2738	82	24	antiepileptic	antiepileptic	ADJ
gs-2738	82	25	drug	drug	NOUN
gs-2738	82	26	response	response	NOUN
gs-2738	82	27	.	.	PUNCT
gs-2738	82	28	.	.	PUNCT
gs-2738	83	1	in	in	ADP
gs-2738	83	2	our	our	PRON
gs-2738	83	3	study	study	NOUN
gs-2738	83	4	va	va	PROPN
gs-2738	83	5	responders	responder	NOUN
gs-2738	83	6	”	"	PUNCT
gs-2738	83	7	had	have	VERB
gs-2738	83	8	significantly	significantly	ADV
gs-2738	83	9	lower	low	ADJ
gs-2738	83	10	pge2	pge2	NOUN
gs-2738	83	11	.	.	PUNCT
gs-2738	84	1	valproic	valproic	ADJ
gs-2738	84	2	acid	acid	NOUN
gs-2738	84	3	(	(	PUNCT
gs-2738	84	4	vpa	vpa	PROPN
gs-2738	84	5	)	)	PUNCT
gs-2738	84	6	is	be	AUX
gs-2738	84	7	primarily	primarily	ADV
gs-2738	84	8	recognized	recognize	VERB
gs-2738	84	9	as	as	ADP
gs-2738	84	10	an	an	DET
gs-2738	84	11	antiepileptic	antiepileptic	ADJ
gs-2738	84	12	and	and	CCONJ
gs-2738	84	13	mood	mood	NOUN
gs-2738	84	14	-	-	PUNCT
gs-2738	84	15	stabilizing	stabilize	VERB
gs-2738	84	16	medication	medication	NOUN
gs-2738	84	17	.	.	PUNCT
gs-2738	85	1	while	while	SCONJ
gs-2738	85	2	its	its	PRON
gs-2738	85	3	primary	primary	ADJ
gs-2738	85	4	mechanism	mechanism	NOUN
gs-2738	85	5	of	of	ADP
gs-2738	85	6	action	action	NOUN
gs-2738	85	7	is	be	AUX
gs-2738	85	8	related	relate	VERB
gs-2738	85	9	to	to	ADP
gs-2738	85	10	the	the	DET
gs-2738	85	11	modulation	modulation	NOUN
gs-2738	85	12	of	of	ADP
gs-2738	85	13	neurotransmission	neurotransmission	NOUN
gs-2738	85	14	,	,	PUNCT
gs-2738	85	15	there	there	PRON
gs-2738	85	16	is	be	VERB
gs-2738	85	17	some	some	DET
gs-2738	85	18	evidence	evidence	NOUN
gs-2738	85	19	to	to	PART
gs-2738	85	20	suggest	suggest	VERB
gs-2738	85	21	that	that	SCONJ
gs-2738	85	22	valproate	valproate	NOUN
gs-2738	85	23	may	may	AUX
gs-2738	85	24	have	have	VERB
gs-2738	85	25	anti	anti	ADJ
gs-2738	85	26	-	-	ADJ
gs-2738	85	27	inflammatory	inflammatory	ADJ
gs-2738	85	28	effects	effect	NOUN
gs-2738	85	29	as	as	ADV
gs-2738	85	30	well	well	ADV
gs-2738	85	31	[	[	X
gs-2738	85	32	26	26	NUM
gs-2738	85	33	]	]	PUNCT
gs-2738	85	34	.	.	PUNCT
gs-2738	86	1	valproate	valproate	ADJ
gs-2738	86	2	has	have	AUX
gs-2738	86	3	been	be	AUX
gs-2738	86	4	shown	show	VERB
gs-2738	86	5	to	to	PART
gs-2738	86	6	reduce	reduce	VERB
gs-2738	86	7	the	the	DET
gs-2738	86	8	activation	activation	NOUN
gs-2738	86	9	of	of	ADP
gs-2738	86	10	immune	immune	ADJ
gs-2738	86	11	cells	cell	NOUN
gs-2738	86	12	like	like	ADP
gs-2738	86	13	microglia	microglia	NOUN
gs-2738	86	14	and	and	CCONJ
gs-2738	86	15	astrocytes	astrocyte	NOUN
gs-2738	86	16	in	in	ADP
gs-2738	86	17	the	the	DET
gs-2738	86	18	central	central	ADJ
gs-2738	86	19	nervous	nervous	ADJ
gs-2738	86	20	system	system	NOUN
gs-2738	86	21	,	,	PUNCT
gs-2738	86	22	it	it	PRON
gs-2738	86	23	decreases	decrease	VERB
gs-2738	86	24	the	the	DET
gs-2738	86	25	production	production	NOUN
gs-2738	86	26	and	and	CCONJ
gs-2738	86	27	release	release	NOUN
gs-2738	86	28	of	of	ADP
gs-2738	86	29	certain	certain	ADJ
gs-2738	86	30	pro	pro	ADJ
gs-2738	86	31	-	-	ADJ
gs-2738	86	32	inflammatory	inflammatory	ADJ
gs-2738	86	33	cytokines	cytokine	NOUN
gs-2738	86	34	,	,	PUNCT
gs-2738	86	35	such	such	ADJ
gs-2738	86	36	as	as	ADP
gs-2738	86	37	interleukin-6	interleukin-6	PROPN
gs-2738	86	38	(	(	PUNCT
gs-2738	86	39	il-6	il-6	NUM
gs-2738	86	40	)	)	PUNCT
gs-2738	86	41	and	and	CCONJ
gs-2738	86	42	tumor	tumor	NOUN
gs-2738	86	43	necrosis	necrosis	NOUN
gs-2738	86	44	factor	factor	NOUN
gs-2738	86	45	-	-	PUNCT
gs-2738	86	46	alpha	alpha	NOUN
gs-2738	86	47	(	(	PUNCT
gs-2738	86	48	tnf	tnf	PROPN
gs-2738	86	49	-	-	PUNCT
gs-2738	86	50	α	α	NOUN
gs-2738	86	51	)	)	PUNCT
gs-2738	87	1	[	[	X
gs-2738	87	2	27	27	NUM
gs-2738	87	3	]	]	PUNCT
gs-2738	87	4	.	.	PUNCT
gs-2738	88	1	these	these	DET
gs-2738	88	2	cytokines	cytokine	NOUN
gs-2738	88	3	are	be	AUX
gs-2738	88	4	key	key	ADJ
gs-2738	88	5	mediators	mediator	NOUN
gs-2738	88	6	of	of	ADP
gs-2738	88	7	the	the	DET
gs-2738	88	8	inflammatory	inflammatory	ADJ
gs-2738	88	9	response	response	NOUN
gs-2738	88	10	,	,	PUNCT
gs-2738	88	11	and	and	CCONJ
gs-2738	88	12	their	their	PRON
gs-2738	88	13	inhibition	inhibition	NOUN
gs-2738	88	14	can	can	AUX
gs-2738	88	15	help	help	VERB
gs-2738	88	16	mitigate	mitigate	VERB
gs-2738	88	17	inflammation	inflammation	NOUN
gs-2738	88	18	.	.	PUNCT
gs-2738	89	1	valproic	valproic	ADJ
gs-2738	89	2	acid	acid	NOUN
gs-2738	89	3	can	can	AUX
gs-2738	89	4	modulate	modulate	VERB
gs-2738	89	5	cox	cox	PROPN
gs-2738	89	6	enzymes	enzyme	NOUN
gs-2738	89	7	in	in	ADP
gs-2738	89	8	the	the	DET
gs-2738	89	9	arachidonic	arachidonic	ADJ
gs-2738	89	10	acid	acid	NOUN
gs-2738	89	11	pathway	pathway	NOUN
gs-2738	89	12	.	.	PUNCT
gs-2738	90	1	valproate	valproate	ADJ
gs-2738	90	2	-	-	PUNCT
gs-2738	90	3	responsive	responsive	ADJ
gs-2738	90	4	patients	patient	NOUN
gs-2738	90	5	exhibit	exhibit	VERB
gs-2738	90	6	decreased	decrease	VERB
gs-2738	90	7	cox-2	cox-2	ADJ
gs-2738	90	8	activity	activity	NOUN
gs-2738	90	9	,	,	PUNCT
gs-2738	90	10	leading	lead	VERB
gs-2738	90	11	to	to	ADP
gs-2738	90	12	lower	low	ADJ
gs-2738	90	13	pge2	pge2	NOUN
gs-2738	90	14	levels	level	NOUN
gs-2738	90	15	.	.	PUNCT
gs-2738	91	1	cox-2	cox-2	NUM
gs-2738	91	2	is	be	AUX
gs-2738	91	3	implicated	implicate	VERB
gs-2738	91	4	in	in	ADP
gs-2738	91	5	stimulating	stimulate	VERB
gs-2738	91	6	p	p	NOUN
gs-2738	91	7	-	-	PUNCT
gs-2738	91	8	glycoprotein	glycoprotein	NOUN
gs-2738	91	9	(	(	PUNCT
gs-2738	91	10	p	p	NOUN
gs-2738	91	11	-	-	PUNCT
gs-2738	91	12	gp	gp	NOUN
gs-2738	91	13	)	)	PUNCT
gs-2738	91	14	,	,	PUNCT
gs-2738	91	15	responsible	responsible	ADJ
gs-2738	91	16	for	for	ADP
gs-2738	91	17	multidrug	multidrug	NOUN
gs-2738	91	18	efflux	efflux	NOUN
gs-2738	91	19	.	.	PUNCT
gs-2738	92	1	studies	study	NOUN
gs-2738	92	2	have	have	AUX
gs-2738	92	3	demonstrated	demonstrate	VERB
gs-2738	92	4	that	that	SCONJ
gs-2738	92	5	disruption	disruption	NOUN
gs-2738	92	6	of	of	ADP
gs-2738	92	7	the	the	DET
gs-2738	92	8	bbb	bbb	PROPN
gs-2738	92	9	correlates	correlate	VERB
gs-2738	92	10	with	with	ADP
gs-2738	92	11	elevated	elevated	ADJ
gs-2738	92	12	cox-2	cox-2	ADJ
gs-2738	92	13	levels	level	NOUN
gs-2738	92	14	and	and	CCONJ
gs-2738	92	15	pge2	pge2	NOUN
gs-2738	92	16	in	in	ADP
gs-2738	92	17	epileptogenic	epileptogenic	ADJ
gs-2738	92	18	areas	area	NOUN
gs-2738	92	19	,	,	PUNCT
gs-2738	92	20	along	along	ADP
gs-2738	92	21	with	with	ADP
gs-2738	92	22	p	p	NOUN
gs-2738	92	23	-	-	PUNCT
gs-2738	92	24	gp	gp	NOUN
gs-2738	92	25	induction	induction	NOUN
gs-2738	92	26	by	by	ADP
gs-2738	92	27	brain	brain	NOUN
gs-2738	92	28	vessels	vessel	NOUN
gs-2738	92	29	and	and	CCONJ
gs-2738	92	30	astrocytes	astrocyte	NOUN
gs-2738	92	31	.	.	PUNCT
gs-2738	93	1	in	in	ADP
gs-2738	93	2	drug	drug	NOUN
gs-2738	93	3	-	-	PUNCT
gs-2738	93	4	resistant	resistant	ADJ
gs-2738	93	5	mesial	mesial	ADJ
gs-2738	93	6	tle	tle	NOUN
gs-2738	93	7	patients	patient	NOUN
gs-2738	93	8	,	,	PUNCT
gs-2738	93	9	a	a	DET
gs-2738	93	10	close	close	ADJ
gs-2738	93	11	association	association	NOUN
gs-2738	93	12	was	be	AUX
gs-2738	93	13	found	find	VERB
gs-2738	93	14	between	between	ADP
gs-2738	93	15	cox-2	cox-2	ADJ
gs-2738	93	16	expression	expression	NOUN
gs-2738	93	17	in	in	ADP
gs-2738	93	18	neurons	neuron	NOUN
gs-2738	93	19	and	and	CCONJ
gs-2738	93	20	glia	glia	NOUN
gs-2738	93	21	,	,	PUNCT
gs-2738	93	22	cox-1	cox-1	NOUN
gs-2738	93	23	expression	expression	NOUN
gs-2738	93	24	in	in	ADP
gs-2738	93	25	microglia	microglia	NOUN
gs-2738	93	26	,	,	PUNCT
gs-2738	93	27	and	and	CCONJ
gs-2738	93	28	p	p	X
gs-2738	93	29	-	-	PUNCT
gs-2738	93	30	gp	gp	NOUN
gs-2738	93	31	and	and	CCONJ
gs-2738	93	32	bcrp	bcrp	ADJ
gs-2738	93	33	expression	expression	NOUN
gs-2738	93	34	in	in	ADP
gs-2738	93	35	small	small	ADJ
gs-2738	93	36	blood	blood	NOUN
gs-2738	93	37	vessels	vessel	NOUN
gs-2738	93	38	.	.	PUNCT
gs-2738	94	1	cox-2	cox-2	ADV
gs-2738	94	2	-	-	PUNCT
gs-2738	94	3	induced	induce	VERB
gs-2738	94	4	upregulation	upregulation	NOUN
gs-2738	94	5	of	of	ADP
gs-2738	94	6	p	p	NOUN
gs-2738	94	7	-	-	PUNCT
gs-2738	94	8	gp	gp	NOUN
gs-2738	94	9	is	be	AUX
gs-2738	94	10	mediated	mediate	VERB
gs-2738	94	11	by	by	ADP
gs-2738	94	12	nmda	nmda	ADJ
gs-2738	94	13	receptors	receptor	NOUN
gs-2738	94	14	,	,	PUNCT
gs-2738	94	15	ca2	ca2	PROPN
gs-2738	94	16	+	+	ADJ
gs-2738	94	17	-dependent	-dependent	ADJ
gs-2738	94	18	activation	activation	NOUN
gs-2738	94	19	of	of	ADP
gs-2738	94	20	phospholipase	phospholipase	NOUN
gs-2738	94	21	a2	a2	PROPN
gs-2738	94	22	,	,	PUNCT
gs-2738	94	23	arachidonic	arachidonic	ADJ
gs-2738	94	24	acid	acid	NOUN
gs-2738	94	25	release	release	NOUN
gs-2738	94	26	,	,	PUNCT
gs-2738	94	27	and	and	CCONJ
gs-2738	94	28	cox-2	cox-2	ADV
gs-2738	94	29	-	-	PUNCT
gs-2738	94	30	mediated	mediate	VERB
gs-2738	94	31	production	production	NOUN
gs-2738	94	32	of	of	ADP
gs-2738	94	33	pge2	pge2	NOUN
gs-2738	94	34	acting	act	VERB
gs-2738	94	35	on	on	ADP
gs-2738	94	36	the	the	DET
gs-2738	94	37	ep1	ep1	NOUN
gs-2738	94	38	receptor	receptor	NOUN
gs-2738	94	39	[	[	X
gs-2738	94	40	28	28	NUM
gs-2738	94	41	]	]	PUNCT
gs-2738	94	42	.	.	PUNCT
gs-2738	95	1	thus	thus	ADV
gs-2738	95	2	,	,	PUNCT
gs-2738	95	3	aeds	aed	NOUN
gs-2738	95	4	can	can	AUX
gs-2738	95	5	reduce	reduce	VERB
gs-2738	95	6	cox-2	cox-2	ADJ
gs-2738	95	7	expression	expression	NOUN
gs-2738	95	8	and	and	CCONJ
gs-2738	95	9	may	may	AUX
gs-2738	95	10	cause	cause	VERB
gs-2738	95	11	a	a	DET
gs-2738	95	12	suppression	suppression	NOUN
gs-2738	95	13	of	of	ADP
gs-2738	95	14	p	p	NOUN
gs-2738	95	15	-	-	PUNCT
gs-2738	95	16	gp	gp	NOUN
gs-2738	95	17	overexpression	overexpression	NOUN
gs-2738	95	18	,	,	PUNCT
gs-2738	95	19	thereby	thereby	ADV
gs-2738	95	20	facilitating	facilitate	VERB
gs-2738	95	21	the	the	DET
gs-2738	95	22	passage	passage	NOUN
gs-2738	95	23	of	of	ADP
gs-2738	95	24	drugs	drug	NOUN
gs-2738	95	25	across	across	ADP
gs-2738	95	26	the	the	DET
gs-2738	95	27	blood	blood	NOUN
gs-2738	95	28	-	-	PUNCT
gs-2738	95	29	brain	brain	NOUN
gs-2738	95	30	barrier	barrier	NOUN
gs-2738	95	31	(	(	PUNCT
gs-2738	95	32	bbb	bbb	NOUN
gs-2738	95	33	)	)	PUNCT
gs-2738	95	34	and	and	CCONJ
gs-2738	95	35	increasing	increase	VERB
gs-2738	95	36	the	the	DET
gs-2738	95	37	effectiveness	effectiveness	NOUN
gs-2738	95	38	of	of	ADP
gs-2738	95	39	those	those	DET
gs-2738	95	40	drugs	drug	NOUN
gs-2738	95	41	.	.	PUNCT
gs-2738	96	1	in	in	ADP
gs-2738	96	2	this	this	DET
gs-2738	96	3	manner	manner	NOUN
gs-2738	96	4	cyclooxygenase-2	cyclooxygenase-2	NUM
gs-2738	96	5	and	and	CCONJ
gs-2738	96	6	pge2	pge2	NOUN
gs-2738	96	7	receptors	receptor	NOUN
gs-2738	96	8	thereby	thereby	ADV
gs-2738	96	9	holding	hold	VERB
gs-2738	96	10	promise	promise	NOUN
gs-2738	96	11	in	in	ADP
gs-2738	96	12	translational	translational	ADJ
gs-2738	96	13	possibility	possibility	NOUN
gs-2738	96	14	with	with	ADP
gs-2738	96	15	goal	goal	NOUN
gs-2738	96	16	to	to	PART
gs-2738	96	17	improve	improve	VERB
gs-2738	96	18	and	and	CCONJ
gs-2738	96	19	restore	restore	VERB
gs-2738	96	20	seizure	seizure	NOUN
gs-2738	96	21	pharmacosensitivity	pharmacosensitivity	NOUN
gs-2738	96	22	and	and	CCONJ
gs-2738	96	23	better	well	ADJ
gs-2738	96	24	epilepsy	epilepsy	ADJ
gs-2738	96	25	management	management	NOUN
gs-2738	96	26	[	[	X
gs-2738	96	27	29	29	NUM
gs-2738	96	28	-	-	SYM
gs-2738	96	29	31	31	NUM
gs-2738	96	30	]	]	PUNCT
gs-2738	96	31	.	.	PUNCT
gs-2738	97	1	it	it	PRON
gs-2738	97	2	may	may	AUX
gs-2738	97	3	therefore	therefore	ADV
gs-2738	97	4	be	be	AUX
gs-2738	97	5	the	the	DET
gs-2738	97	6	reason	reason	NOUN
gs-2738	97	7	why	why	SCONJ
gs-2738	97	8	valproate	valproate	ADJ
gs-2738	97	9	responders	responder	NOUN
gs-2738	97	10	exhibit	exhibit	VERB
gs-2738	97	11	lower	low	ADJ
gs-2738	97	12	levels	level	NOUN
gs-2738	97	13	of	of	ADP
gs-2738	97	14	pge2	pge2	NOUN
gs-2738	97	15	in	in	ADP
gs-2738	97	16	our	our	PRON
gs-2738	97	17	study	study	NOUN
gs-2738	97	18	groups	group	NOUN
gs-2738	97	19	.	.	PUNCT
gs-2738	98	1	georgian	georgian	ADJ
gs-2738	98	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-2738	98	3	მეცნიერები	მეცნიერები	NOUN
gs-2738	98	4	ტ.	ტ.	VERB
gs-2738	98	5	6	6	NUM
gs-2738	98	6	n	n	NUM
gs-2738	98	7	1	1	NUM
gs-2738	98	8	,	,	PUNCT
gs-2738	98	9	2024	2024	NUM
gs-2738	98	10	296	296	NUM
gs-2738	98	11	it	it	PRON
gs-2738	98	12	's	be	AUX
gs-2738	98	13	important	important	ADJ
gs-2738	98	14	to	to	PART
gs-2738	98	15	note	note	VERB
gs-2738	98	16	that	that	SCONJ
gs-2738	98	17	while	while	SCONJ
gs-2738	98	18	there	there	PRON
gs-2738	98	19	is	be	VERB
gs-2738	98	20	limited	limit	VERB
gs-2738	98	21	clinical	clinical	ADJ
gs-2738	98	22	studies	study	NOUN
gs-2738	98	23	some	some	DET
gs-2738	98	24	research	research	NOUN
gs-2738	98	25	on	on	ADP
gs-2738	98	26	the	the	DET
gs-2738	98	27	potential	potential	ADJ
gs-2738	98	28	effects	effect	NOUN
gs-2738	98	29	of	of	ADP
gs-2738	98	30	valproic	valproic	ADJ
gs-2738	98	31	acid	acid	NOUN
gs-2738	98	32	on	on	ADP
gs-2738	98	33	cytokine	cytokine	ADJ
gs-2738	98	34	levels	level	NOUN
gs-2738	98	35	,	,	PUNCT
gs-2738	98	36	the	the	DET
gs-2738	98	37	precise	precise	ADJ
gs-2738	98	38	mechanisms	mechanism	NOUN
gs-2738	98	39	and	and	CCONJ
gs-2738	98	40	clinical	clinical	ADJ
gs-2738	98	41	significance	significance	NOUN
gs-2738	98	42	of	of	ADP
gs-2738	98	43	these	these	DET
gs-2738	98	44	effects	effect	NOUN
gs-2738	98	45	are	be	AUX
gs-2738	98	46	not	not	PART
gs-2738	98	47	fully	fully	ADV
gs-2738	98	48	elucidated	elucidated	ADJ
gs-2738	98	49	.	.	PUNCT
gs-2738	99	1	the	the	DET
gs-2738	99	2	effects	effect	NOUN
gs-2738	99	3	of	of	ADP
gs-2738	99	4	valproic	valproic	ADJ
gs-2738	99	5	acid	acid	NOUN
gs-2738	99	6	on	on	ADP
gs-2738	99	7	pge2	pge2	NOUN
gs-2738	99	8	levels	level	NOUN
gs-2738	99	9	can	can	AUX
gs-2738	99	10	vary	vary	VERB
gs-2738	99	11	among	among	ADP
gs-2738	99	12	individuals	individual	NOUN
gs-2738	99	13	[	[	X
gs-2738	99	14	32	32	NUM
gs-2738	99	15	]	]	PUNCT
gs-2738	99	16	.	.	PUNCT
gs-2738	100	1	genetic	genetic	ADJ
gs-2738	100	2	factors	factor	NOUN
gs-2738	100	3	,	,	PUNCT
gs-2738	100	4	underlying	underlying	ADJ
gs-2738	100	5	medical	medical	ADJ
gs-2738	100	6	conditions	condition	NOUN
gs-2738	100	7	,	,	PUNCT
gs-2738	100	8	and	and	CCONJ
gs-2738	100	9	the	the	DET
gs-2738	100	10	specific	specific	ADJ
gs-2738	100	11	dosage	dosage	NOUN
gs-2738	100	12	and	and	CCONJ
gs-2738	100	13	duration	duration	NOUN
gs-2738	100	14	of	of	ADP
gs-2738	100	15	valproic	valproic	ADJ
gs-2738	100	16	acid	acid	NOUN
gs-2738	100	17	treatment	treatment	NOUN
gs-2738	100	18	can	can	AUX
gs-2738	100	19	all	all	ADV
gs-2738	100	20	contribute	contribute	VERB
gs-2738	100	21	to	to	ADP
gs-2738	100	22	variability	variability	NOUN
gs-2738	100	23	in	in	ADP
gs-2738	100	24	its	its	PRON
gs-2738	100	25	effects	effect	NOUN
gs-2738	100	26	.	.	PUNCT
gs-2738	101	1	more	more	ADJ
gs-2738	101	2	research	research	NOUN
gs-2738	101	3	is	be	AUX
gs-2738	101	4	needed	need	VERB
gs-2738	101	5	to	to	PART
gs-2738	101	6	understand	understand	VERB
gs-2738	101	7	the	the	DET
gs-2738	101	8	specific	specific	ADJ
gs-2738	101	9	interactions	interaction	NOUN
gs-2738	101	10	in	in	ADP
gs-2738	101	11	various	various	ADJ
gs-2738	101	12	contexts.any	contexts.any	NUM
gs-2738	101	13	potential	potential	ADJ
gs-2738	101	14	interactions	interaction	NOUN
gs-2738	101	15	should	should	AUX
gs-2738	101	16	be	be	AUX
gs-2738	101	17	considered	consider	VERB
gs-2738	101	18	within	within	ADP
gs-2738	101	19	the	the	DET
gs-2738	101	20	broader	broad	ADJ
gs-2738	101	21	context	context	NOUN
gs-2738	101	22	of	of	ADP
gs-2738	101	23	a	a	DET
gs-2738	101	24	patient	patient	NOUN
gs-2738	101	25	's	's	PART
gs-2738	101	26	medical	medical	ADJ
gs-2738	101	27	condition	condition	NOUN
gs-2738	101	28	and	and	CCONJ
gs-2738	101	29	treatment	treatment	NOUN
gs-2738	101	30	plan	plan	NOUN
gs-2738	101	31	,	,	PUNCT
gs-2738	101	32	based	base	VERB
gs-2738	101	33	on	on	ADP
gs-2738	101	34	their	their	PRON
gs-2738	101	35	specific	specific	ADJ
gs-2738	101	36	clinical	clinical	ADJ
gs-2738	101	37	response	response	NOUN
gs-2738	101	38	.	.	PUNCT
gs-2738	102	1	,	,	PUNCT
gs-2738	102	2	the	the	DET
gs-2738	102	3	anti	anti	ADJ
gs-2738	102	4	-	-	ADJ
gs-2738	102	5	inflammatory	inflammatory	ADJ
gs-2738	102	6	effects	effect	NOUN
gs-2738	102	7	of	of	ADP
gs-2738	102	8	valproate	valproate	NOUN
gs-2738	102	9	are	be	AUX
gs-2738	102	10	not	not	PART
gs-2738	102	11	as	as	ADV
gs-2738	102	12	well	well	ADV
gs-2738	102	13	-	-	PUNCT
gs-2738	102	14	established	establish	VERB
gs-2738	102	15	as	as	ADP
gs-2738	102	16	its	its	PRON
gs-2738	102	17	primary	primary	ADJ
gs-2738	102	18	therapeutic	therapeutic	ADJ
gs-2738	102	19	actions	action	NOUN
gs-2738	102	20	,	,	PUNCT
gs-2738	102	21	if	if	SCONJ
gs-2738	102	22	confirmed	confirm	VERB
gs-2738	102	23	through	through	ADP
gs-2738	102	24	further	further	ADJ
gs-2738	102	25	research	research	NOUN
gs-2738	102	26	anti	anti	ADJ
gs-2738	102	27	-	-	ADJ
gs-2738	102	28	inflammatory	inflammatory	ADJ
gs-2738	102	29	properties	property	NOUN
gs-2738	102	30	could	could	AUX
gs-2738	102	31	be	be	AUX
gs-2738	102	32	considered	consider	VERB
gs-2738	102	33	as	as	ADP
gs-2738	102	34	secondary	secondary	ADJ
gs-2738	102	35	benefit	benefit	NOUN
gs-2738	102	36	in	in	ADP
gs-2738	102	37	the	the	DET
gs-2738	102	38	management	management	NOUN
gs-2738	102	39	of	of	ADP
gs-2738	102	40	epilepsy	epilepsy	NOUN
gs-2738	102	41	.	.	PUNCT
gs-2738	103	1	to	to	ADP
gs-2738	103	2	the	the	DET
gs-2738	103	3	best	good	ADJ
gs-2738	103	4	of	of	ADP
gs-2738	103	5	our	our	PRON
gs-2738	103	6	knowledge	knowledge	NOUN
gs-2738	103	7	,	,	PUNCT
gs-2738	103	8	our	our	PRON
gs-2738	103	9	study	study	NOUN
gs-2738	103	10	is	be	AUX
gs-2738	103	11	the	the	DET
gs-2738	103	12	pilot	pilot	NOUN
gs-2738	103	13	report	report	NOUN
gs-2738	103	14	of	of	ADP
gs-2738	103	15	the	the	DET
gs-2738	103	16	possible	possible	ADJ
gs-2738	103	17	association	association	NOUN
gs-2738	103	18	between	between	ADP
gs-2738	103	19	plasma	plasma	NOUN
gs-2738	103	20	pge2	pge2	NOUN
gs-2738	103	21	levels	level	NOUN
gs-2738	103	22	and	and	CCONJ
gs-2738	103	23	epilepsy	epilepsy	NOUN
gs-2738	103	24	and	and	CCONJ
gs-2738	103	25	drug	drug	NOUN
gs-2738	103	26	response	response	NOUN
gs-2738	103	27	.	.	PUNCT
gs-2738	104	1	the	the	DET
gs-2738	104	2	study	study	NOUN
gs-2738	104	3	presented	present	VERB
gs-2738	104	4	certain	certain	ADJ
gs-2738	104	5	limitations	limitation	NOUN
gs-2738	104	6	,	,	PUNCT
gs-2738	104	7	including	include	VERB
gs-2738	104	8	a	a	DET
gs-2738	104	9	small	small	ADJ
gs-2738	104	10	sample	sample	NOUN
gs-2738	104	11	size	size	NOUN
gs-2738	104	12	and	and	CCONJ
gs-2738	104	13	the	the	DET
gs-2738	104	14	assessment	assessment	NOUN
gs-2738	104	15	of	of	ADP
gs-2738	104	16	cytokine	cytokine	ADJ
gs-2738	104	17	levels	level	NOUN
gs-2738	104	18	at	at	ADP
gs-2738	104	19	only	only	ADV
gs-2738	104	20	a	a	DET
gs-2738	104	21	single	single	ADJ
gs-2738	104	22	time	time	NOUN
gs-2738	104	23	point	point	NOUN
gs-2738	104	24	during	during	ADP
gs-2738	104	25	the	the	DET
gs-2738	104	26	interictal	interictal	ADJ
gs-2738	104	27	period	period	NOUN
gs-2738	104	28	.	.	PUNCT
gs-2738	105	1	treatment	treatment	NOUN
gs-2738	105	2	resistance	resistance	NOUN
gs-2738	105	3	is	be	AUX
gs-2738	105	4	very	very	ADV
gs-2738	105	5	probably	probably	ADV
gs-2738	105	6	not	not	PART
gs-2738	105	7	caused	cause	VERB
gs-2738	105	8	by	by	ADP
gs-2738	105	9	a	a	DET
gs-2738	105	10	single	single	ADJ
gs-2738	105	11	mechanism	mechanism	NOUN
gs-2738	105	12	.but	.but	PUNCT
gs-2738	106	1	our	our	PRON
gs-2738	106	2	findings	finding	NOUN
gs-2738	106	3	support	support	VERB
gs-2738	106	4	the	the	DET
gs-2738	106	5	evidence	evidence	NOUN
gs-2738	106	6	that	that	PRON
gs-2738	106	7	inflammatory	inflammatory	ADJ
gs-2738	106	8	pathways	pathway	NOUN
gs-2738	106	9	could	could	AUX
gs-2738	106	10	have	have	VERB
gs-2738	106	11	impact	impact	NOUN
gs-2738	106	12	on	on	ADP
gs-2738	106	13	antiepileptic	antiepileptic	ADJ
gs-2738	106	14	drug	drug	NOUN
gs-2738	106	15	response	response	NOUN
gs-2738	106	16	.	.	PUNCT
gs-2738	107	1	limited	limited	ADJ
gs-2738	107	2	clinical	clinical	ADJ
gs-2738	107	3	trial	trial	NOUN
gs-2738	107	4	experience	experience	NOUN
gs-2738	107	5	is	be	AUX
gs-2738	107	6	supportive	supportive	ADJ
gs-2738	107	7	but	but	CCONJ
gs-2738	107	8	not	not	PART
gs-2738	107	9	definitive	definitive	ADJ
gs-2738	107	10	for	for	ADP
gs-2738	107	11	a	a	DET
gs-2738	107	12	role	role	NOUN
gs-2738	107	13	of	of	ADP
gs-2738	107	14	the	the	DET
gs-2738	107	15	cox	cox	PROPN
gs-2738	107	16	signaling	signal	VERB
gs-2738	107	17	cascade	cascade	NOUN
gs-2738	107	18	in	in	ADP
gs-2738	107	19	epileptogenesis	epileptogenesis	NOUN
gs-2738	107	20	.	.	PUNCT
gs-2738	108	1	future	future	ADJ
gs-2738	108	2	work	work	NOUN
gs-2738	108	3	may	may	AUX
gs-2738	108	4	emphasize	emphasize	VERB
gs-2738	108	5	on	on	ADP
gs-2738	108	6	validating	validate	VERB
gs-2738	108	7	the	the	DET
gs-2738	108	8	findings	finding	NOUN
gs-2738	108	9	in	in	ADP
gs-2738	108	10	in	in	ADP
gs-2738	108	11	the	the	DET
gs-2738	108	12	expanded	expand	VERB
gs-2738	108	13	and	and	CCONJ
gs-2738	108	14	timeextended	timeextende	VERB
gs-2738	108	15	cohort	cohort	NOUN
gs-2738	108	16	of	of	ADP
gs-2738	108	17	patients	patient	NOUN
gs-2738	108	18	.	.	PUNCT
gs-2738	109	1	furthermore	furthermore	ADV
gs-2738	109	2	,	,	PUNCT
gs-2738	109	3	molecular	molecular	ADJ
gs-2738	109	4	mechanisms	mechanism	NOUN
gs-2738	109	5	underlying	underlie	VERB
gs-2738	109	6	the	the	DET
gs-2738	109	7	role	role	NOUN
gs-2738	109	8	of	of	ADP
gs-2738	109	9	cox-2	cox-2	NOUN
gs-2738	109	10	or	or	CCONJ
gs-2738	109	11	pge2	pge2	NOUN
gs-2738	109	12	in	in	ADP
gs-2738	109	13	aed	aed	NOUN
gs-2738	109	14	efficacy	efficacy	NOUN
gs-2738	109	15	needs	need	VERB
gs-2738	109	16	to	to	PART
gs-2738	109	17	be	be	AUX
gs-2738	109	18	explored	explore	VERB
gs-2738	109	19	as	as	ADP
gs-2738	109	20	a	a	DET
gs-2738	109	21	new	new	ADJ
gs-2738	109	22	target	target	NOUN
gs-2738	109	23	system	system	NOUN
gs-2738	109	24	for	for	ADP
gs-2738	109	25	pharmacological	pharmacological	ADJ
gs-2738	109	26	intervention	intervention	NOUN
gs-2738	109	27	to	to	PART
gs-2738	109	28	inhibit	inhibit	VERB
gs-2738	109	29	seizures	seizure	NOUN
gs-2738	109	30	by	by	ADP
gs-2738	109	31	interfering	interfere	VERB
gs-2738	109	32	with	with	ADP
gs-2738	109	33	neuroinflammatory	neuroinflammatory	ADJ
gs-2738	109	34	mechanisms	mechanism	NOUN
gs-2738	109	35	involved	involve	VERB
gs-2738	109	36	in	in	ADP
gs-2738	109	37	seizure	seizure	NOUN
gs-2738	109	38	genesis	genesis	NOUN
gs-2738	109	39	and	and	CCONJ
gs-2738	109	40	recurrence	recurrence	NOUN
gs-2738	109	41	.	.	PUNCT
gs-2738	110	1	it	it	PRON
gs-2738	110	2	is	be	AUX
gs-2738	110	3	of	of	ADP
gs-2738	110	4	paramount	paramount	ADJ
gs-2738	110	5	importance	importance	NOUN
gs-2738	110	6	to	to	PART
gs-2738	110	7	gain	gain	VERB
gs-2738	110	8	a	a	DET
gs-2738	110	9	comprehensive	comprehensive	ADJ
gs-2738	110	10	understanding	understanding	NOUN
gs-2738	110	11	of	of	ADP
gs-2738	110	12	the	the	DET
gs-2738	110	13	extendedterm	extendedterm	NOUN
gs-2738	110	14	clinical	clinical	ADJ
gs-2738	110	15	trajectories	trajectory	NOUN
gs-2738	110	16	and	and	CCONJ
gs-2738	110	17	potential	potential	NOUN
gs-2738	110	18	on	on	ADP
gs-2738	110	19	molecular	molecular	ADJ
gs-2738	110	20	basis	basis	NOUN
gs-2738	110	21	for	for	ADP
gs-2738	110	22	overcoming	overcome	VERB
gs-2738	110	23	drug	drug	NOUN
gs-2738	110	24	resistance	resistance	NOUN
gs-2738	110	25	,	,	PUNCT
gs-2738	110	26	ideally	ideally	ADV
gs-2738	110	27	guided	guide	VERB
gs-2738	110	28	by	by	ADP
gs-2738	110	29	biomarker	biomarker	NOUN
gs-2738	110	30	of	of	ADP
gs-2738	110	31	patient	patient	NOUN
gs-2738	110	32	’s	’s	PART
gs-2738	110	33	failure	failure	NOUN
gs-2738	110	34	to	to	PART
gs-2738	110	35	seizure	seizure	VERB
gs-2738	110	36	freedom	freedom	NOUN
gs-2738	110	37	,	,	PUNCT
gs-2738	110	38	which	which	PRON
gs-2738	110	39	is	be	AUX
gs-2738	110	40	a	a	DET
gs-2738	110	41	major	major	ADJ
gs-2738	110	42	challenge	challenge	NOUN
gs-2738	110	43	and	and	CCONJ
gs-2738	110	44	key	key	NOUN
gs-2738	110	45	toward	toward	ADP
gs-2738	110	46	precision	precision	NOUN
gs-2738	110	47	medicine	medicine	NOUN
gs-2738	110	48	in	in	ADP
gs-2738	110	49	epilepsy	epilepsy	NOUN
gs-2738	110	50	management	management	NOUN
gs-2738	110	51	.	.	PUNCT
gs-2738	111	1	conflicts	conflict	NOUN
gs-2738	111	2	of	of	ADP
gs-2738	111	3	interest	interest	NOUN
gs-2738	111	4	the	the	DET
gs-2738	111	5	authors	author	NOUN
gs-2738	111	6	declare	declare	VERB
gs-2738	111	7	that	that	SCONJ
gs-2738	111	8	they	they	PRON
gs-2738	111	9	have	have	VERB
gs-2738	111	10	no	no	DET
gs-2738	111	11	conflicts	conflict	NOUN
gs-2738	111	12	of	of	ADP
gs-2738	111	13	interest	interest	NOUN
gs-2738	111	14	.	.	PUNCT
gs-2738	112	1	funding	fund	VERB
gs-2738	112	2	this	this	DET
gs-2738	112	3	research	research	NOUN
gs-2738	112	4	was	be	AUX
gs-2738	112	5	funded	fund	VERB
gs-2738	112	6	by	by	ADP
gs-2738	112	7	the	the	DET
gs-2738	112	8	shota	shota	ADJ
gs-2738	112	9	rustaveli	rustaveli	ADJ
gs-2738	112	10	national	national	PROPN
gs-2738	112	11	science	science	PROPN
gs-2738	112	12	foundation	foundation	PROPN
gs-2738	112	13	of	of	ADP
gs-2738	112	14	georgia	georgia	PROPN
gs-2738	112	15	fundamental	fundamental	PROPN
gs-2738	112	16	research	research	PROPN
gs-2738	112	17	foundation	foundation	PROPN
gs-2738	112	18	,	,	PUNCT
gs-2738	112	19	grant	grant	VERB
gs-2738	112	20	fr-18	fr-18	NOUN
gs-2738	112	21	-	-	SYM
gs-2738	112	22	16052	16052	NUM
gs-2738	112	23	.	.	PUNCT
gs-2738	113	1	references	reference	NOUN
gs-2738	113	2	1	1	NUM
gs-2738	113	3	.	.	PUNCT
gs-2738	114	1	aaberg	aaberg	PROPN
gs-2738	114	2	,	,	PUNCT
gs-2738	114	3	k.m	k.m	PROPN
gs-2738	114	4	.	.	PROPN
gs-2738	114	5	;	;	PUNCT
gs-2738	114	6	gunnes	gunne	NOUN
gs-2738	114	7	,	,	PUNCT
gs-2738	114	8	n.	n.	NOUN
gs-2738	114	9	;	;	PUNCT
gs-2738	114	10	bakken	bakken	PROPN
gs-2738	114	11	,	,	PUNCT
gs-2738	114	12	i.j	i.j	PROPN
gs-2738	114	13	.	.	PROPN
gs-2738	114	14	;	;	PUNCT
gs-2738	114	15	søraas	søraas	NOUN
gs-2738	114	16	,	,	PUNCT
gs-2738	114	17	c.l	c.l	PROPN
gs-2738	114	18	.	.	PROPN
gs-2738	114	19	;	;	PUNCT
gs-2738	114	20	berntsen	berntsen	PROPN
gs-2738	114	21	,	,	PUNCT
gs-2738	114	22	a.	a.	NOUN
gs-2738	114	23	;	;	PUNCT
gs-2738	114	24	magnus	magnus	PROPN
gs-2738	114	25	,	,	PUNCT
gs-2738	114	26	p.	p.	NOUN
gs-2738	114	27	;	;	PUNCT
gs-2738	114	28	lossius	lossius	PROPN
gs-2738	114	29	,	,	PUNCT
gs-2738	114	30	m.i	m.i	PROPN
gs-2738	114	31	.	.	PROPN
gs-2738	114	32	;	;	PUNCT
gs-2738	114	33	stoltenberg	stoltenberg	PROPN
gs-2738	114	34	,	,	PUNCT
gs-2738	114	35	c.	c.	PROPN
gs-2738	114	36	;	;	PUNCT
gs-2738	114	37	chin	chin	PROPN
gs-2738	114	38	,	,	PUNCT
gs-2738	114	39	r.	r.	PROPN
gs-2738	114	40	;	;	PUNCT
gs-2738	114	41	surén	surén	PROPN
gs-2738	114	42	,	,	PUNCT
gs-2738	114	43	p.	p.	NOUN
gs-2738	114	44	incidence	incidence	NOUN
gs-2738	114	45	and	and	CCONJ
gs-2738	114	46	prevalence	prevalence	NOUN
gs-2738	114	47	of	of	ADP
gs-2738	114	48	childhood	childhood	NOUN
gs-2738	114	49	epilepsy	epilepsy	PROPN
gs-2738	114	50	:	:	PUNCT
gs-2738	114	51	a	a	DET
gs-2738	114	52	nationwide	nationwide	ADJ
gs-2738	114	53	cohort	cohort	NOUN
gs-2738	114	54	study	study	NOUN
gs-2738	114	55	.	.	PUNCT
gs-2738	115	1	pediatrics	pediatric	NOUN
gs-2738	115	2	2017	2017	NUM
gs-2738	115	3	.	.	PUNCT
gs-2738	116	1	2	2	X
gs-2738	116	2	.	.	X
gs-2738	116	3	zack	zack	PROPN
gs-2738	116	4	,	,	PUNCT
gs-2738	116	5	m.m	m.m	PROPN
gs-2738	116	6	.	.	PROPN
gs-2738	116	7	;	;	PUNCT
gs-2738	116	8	kobau	kobau	PROPN
gs-2738	116	9	,	,	PUNCT
gs-2738	116	10	r.	r.	PROPN
gs-2738	116	11	national	national	PROPN
gs-2738	116	12	and	and	CCONJ
gs-2738	116	13	state	state	NOUN
gs-2738	116	14	estimates	estimate	NOUN
gs-2738	116	15	of	of	ADP
gs-2738	116	16	the	the	DET
gs-2738	116	17	numbers	number	NOUN
gs-2738	116	18	of	of	ADP
gs-2738	116	19	adults	adult	NOUN
gs-2738	116	20	and	and	CCONJ
gs-2738	116	21	children	child	NOUN
gs-2738	116	22	with	with	ADP
gs-2738	116	23	active	active	ADJ
gs-2738	116	24	epilepsy	epilepsy	NOUN
gs-2738	116	25	united	united	PROPN
gs-2738	116	26	states	states	PROPN
gs-2738	116	27	,	,	PUNCT
gs-2738	116	28	2015	2015	NUM
gs-2738	116	29	.	.	PUNCT
gs-2738	117	1	mmwr	mmwr	NOUN
gs-2738	117	2	.	.	PUNCT
gs-2738	118	1	morb	morb	NOUN
gs-2738	118	2	.	.	PUNCT
gs-2738	119	1	mortal	mortal	ADJ
gs-2738	119	2	.	.	PUNCT
gs-2738	120	1	wkly	wkly	PROPN
gs-2738	120	2	.	.	PUNCT
gs-2738	121	1	rep	rep	PROPN
gs-2738	121	2	.	.	PROPN
gs-2738	121	3	2017	2017	NUM
gs-2738	121	4	,	,	PUNCT
gs-2738	121	5	66	66	NUM
gs-2738	121	6	,	,	PUNCT
gs-2738	121	7	821–825	821–825	NUM
gs-2738	121	8	.	.	PUNCT
gs-2738	122	1	georgian	georgian	ADJ
gs-2738	122	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-2738	122	3	მეცნიერები	მეცნიერები	NOUN
gs-2738	122	4	ტ.	ტ.	VERB
gs-2738	122	5	6	6	NUM
gs-2738	122	6	n	n	NUM
gs-2738	122	7	1	1	NUM
gs-2738	122	8	,	,	PUNCT
gs-2738	122	9	2024	2024	NUM
gs-2738	122	10	297	297	NUM
gs-2738	122	11	3	3	NUM
gs-2738	122	12	.	.	PUNCT
gs-2738	122	13	symonds	symond	NOUN
gs-2738	122	14	,	,	PUNCT
gs-2738	122	15	j.d	j.d	PROPN
gs-2738	122	16	.	.	PROPN
gs-2738	122	17	;	;	PUNCT
gs-2738	122	18	elliott	elliott	PROPN
gs-2738	122	19	,	,	PUNCT
gs-2738	122	20	k.s	k.s	PROPN
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gs-2738	122	23	shetty	shetty	PROPN
gs-2738	122	24	,	,	PUNCT
gs-2738	122	25	j.	j.	PROPN
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gs-2738	122	30	;	;	PUNCT
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gs-2738	122	34	;	;	PUNCT
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gs-2738	122	37	i.a	i.a	PROPN
gs-2738	122	38	.	.	PROPN
gs-2738	122	39	;	;	PUNCT
gs-2738	122	40	diver	diver	PROPN
gs-2738	122	41	,	,	PUNCT
gs-2738	122	42	l.	l.	PROPN
gs-2738	122	43	;	;	PUNCT
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gs-2738	122	45	,	,	PUNCT
gs-2738	122	46	l.	l.	PROPN
gs-2738	122	47	;	;	PUNCT
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gs-2738	122	49	,	,	PUNCT
gs-2738	122	50	s.	s.	PROPN
gs-2738	122	51	;	;	PUNCT
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gs-2738	122	53	,	,	PUNCT
gs-2738	122	54	a.	a.	NOUN
gs-2738	122	55	;	;	PUNCT
gs-2738	122	56	et	et	PROPN
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gs-2738	123	1	early	early	ADJ
gs-2738	123	2	childhood	childhood	ADJ
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gs-2738	123	4	:	:	PUNCT
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gs-2738	123	8	,	,	PUNCT
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gs-2738	123	13	-	-	PUNCT
gs-2738	123	14	economic	economic	ADJ
gs-2738	123	15	determinants	determinant	NOUN
gs-2738	123	16	.	.	PUNCT
gs-2738	124	1	brain	brain	NOUN
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gs-2738	124	3	,	,	PUNCT
gs-2738	124	4	144	144	NUM
gs-2738	124	5	,	,	PUNCT
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gs-2738	124	7	.	.	NOUN
gs-2738	124	8	4	4	NUM
gs-2738	124	9	.	.	X
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gs-2738	124	11	,	,	PUNCT
gs-2738	124	12	p.	p.	PROPN
gs-2738	124	13	;	;	PUNCT
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gs-2738	124	17	;	;	PUNCT
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gs-2738	124	20	a.t	a.t	PROPN
gs-2738	124	21	.	.	PROPN
gs-2738	124	22	;	;	PUNCT
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gs-2738	124	24	,	,	PUNCT
gs-2738	124	25	m.j	m.j	PROPN
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gs-2738	124	27	;	;	PUNCT
gs-2738	124	28	allen	allen	PROPN
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gs-2738	124	30	,	,	PUNCT
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gs-2738	124	32	;	;	PUNCT
gs-2738	124	33	mathern	mathern	PROPN
gs-2738	124	34	,	,	PUNCT
gs-2738	124	35	g.	g.	PROPN
gs-2738	124	36	;	;	PUNCT
gs-2738	124	37	moshé	moshé	ADJ
gs-2738	124	38	,	,	PUNCT
gs-2738	124	39	s.l	s.l	PROPN
gs-2738	124	40	.	.	PROPN
gs-2738	124	41	;	;	PUNCT
gs-2738	124	42	perucca	perucca	PROPN
gs-2738	124	43	,	,	PUNCT
gs-2738	124	44	e.	e.	PROPN
gs-2738	124	45	;	;	PUNCT
gs-2738	124	46	wiebe	wiebe	PROPN
gs-2738	124	47	,	,	PUNCT
gs-2738	124	48	s.	s.	PROPN
gs-2738	124	49	;	;	PUNCT
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gs-2738	124	52	j.	j.	PROPN
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gs-2738	124	54	of	of	ADP
gs-2738	124	55	drug	drug	NOUN
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gs-2738	124	57	epilepsy	epilepsy	NOUN
gs-2738	124	58	:	:	PUNCT
gs-2738	124	59	consensus	consensus	NOUN
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gs-2738	124	61	by	by	ADP
gs-2738	124	62	the	the	DET
gs-2738	124	63	ad	ad	X
gs-2738	124	64	hoc	hoc	X
gs-2738	124	65	task	task	NOUN
gs-2738	124	66	force	force	NOUN
gs-2738	124	67	of	of	ADP
gs-2738	124	68	the	the	DET
gs-2738	124	69	ilae	ilae	NOUN
gs-2738	124	70	commission	commission	NOUN
gs-2738	124	71	on	on	ADP
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gs-2738	124	73	strategies	strategy	NOUN
gs-2738	124	74	.	.	PUNCT
gs-2738	125	1	epilepsia	epilepsia	NOUN
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gs-2738	125	3	,	,	PUNCT
gs-2738	125	4	51	51	NUM
gs-2738	125	5	,	,	PUNCT
gs-2738	125	6	1069	1069	NUM
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gs-2738	125	8	1077	1077	NUM
gs-2738	125	9	.	.	PUNCT
gs-2738	126	1	5	5	NUM
gs-2738	126	2	.	.	X
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gs-2738	127	3	,	,	PUNCT
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gs-2738	128	1	the	the	DET
gs-2738	128	2	role	role	NOUN
gs-2738	128	3	of	of	ADP
gs-2738	128	4	inflammation	inflammation	NOUN
gs-2738	128	5	in	in	ADP
gs-2738	128	6	the	the	DET
gs-2738	128	7	development	development	NOUN
gs-2738	128	8	of	of	ADP
gs-2738	128	9	epilepsy	epilepsy	PROPN
gs-2738	128	10	.	.	PUNCT
gs-2738	129	1	j	j	PROPN
gs-2738	129	2	neuroinflammation	neuroinflammation	PROPN
gs-2738	129	3	.	.	PUNCT
gs-2738	130	1	2018;15(1):144	2018;15(1):144	NUM
gs-2738	130	2	.	.	PUNCT
gs-2738	131	1	published	publish	VERB
gs-2738	131	2	2018	2018	NUM
gs-2738	131	3	doi:10.1186	doi:10.1186	NOUN
gs-2738	131	4	/	/	SYM
gs-2738	131	5	s12974	s12974	NOUN
gs-2738	131	6	-	-	PUNCT
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gs-2738	131	8	-	-	PUNCT
gs-2738	131	9	1192	1192	NUM
gs-2738	131	10	-	-	SYM
gs-2738	131	11	7	7	NUM
gs-2738	131	12	6	6	NUM
gs-2738	131	13	.	.	PUNCT
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gs-2738	132	2	y	y	PROPN
gs-2738	132	3	,	,	PUNCT
gs-2738	132	4	nagib	nagib	PROPN
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gs-2738	132	6	,	,	PUNCT
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gs-2738	132	8	n	n	CCONJ
gs-2738	132	9	,	,	PUNCT
gs-2738	132	10	et	et	PROPN
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gs-2738	132	12	.	.	PUNCT
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gs-2738	133	3	in	in	ADP
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gs-2738	133	5	epilepsy	epilepsy	NOUN
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gs-2738	133	7	an	an	DET
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gs-2738	133	9	.	.	PUNCT
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gs-2738	134	3	.	.	PUNCT
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gs-2738	135	2	-	-	PUNCT
gs-2738	135	3	701	701	NUM
gs-2738	135	4	.	.	PUNCT
gs-2738	136	1	doi:10.1007	doi:10.1007	VERB
gs-2738	136	2	/	/	SYM
gs-2738	136	3	s00011	s00011	NUM
gs-2738	136	4	-	-	PUNCT
gs-2738	136	5	023	023	NUM
gs-2738	136	6	-	-	PUNCT
gs-2738	136	7	01700	01700	NUM
gs-2738	136	8	-	-	SYM
gs-2738	136	9	8	8	NUM
gs-2738	136	10	7	7	NUM
gs-2738	136	11	.	.	PUNCT
gs-2738	137	1	jiang	jiang	PROPN
gs-2738	137	2	j	j	PROPN
gs-2738	137	3	,	,	PUNCT
gs-2738	137	4	santhakumar	santhakumar	PROPN
gs-2738	137	5	v	v	PROPN
gs-2738	137	6	,	,	PUNCT
gs-2738	137	7	zhu	zhu	PROPN
gs-2738	137	8	x.	x.	NOUN
gs-2738	137	9	editorial	editorial	PROPN
gs-2738	137	10	:	:	PUNCT
gs-2738	137	11	neuroinflammation	neuroinflammation	NOUN
gs-2738	137	12	in	in	ADP
gs-2738	137	13	acquired	acquire	VERB
gs-2738	137	14	epilepsy	epilepsy	NOUN
gs-2738	137	15	.	.	PUNCT
gs-2738	138	1	frontiers	frontier	NOUN
gs-2738	138	2	in	in	ADP
gs-2738	138	3	cell	cell	NOUN
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gs-2738	138	6	biology	biology	NOUN
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gs-2738	138	8	;	;	PUNCT
gs-2738	138	9	10.3389	10.3389	NUM
gs-2738	138	10	/	/	SYM
gs-2738	138	11	fcell.2022.1074537	fcell.2022.1074537	NOUN
gs-2738	138	12	.	.	NOUN
gs-2738	138	13	8	8	NUM
gs-2738	138	14	.	.	PUNCT
gs-2738	139	1	mukhtar	mukhtar	PROPN
gs-2738	139	2	i.	i.	PROPN
gs-2738	139	3	inflammatory	inflammatory	ADJ
gs-2738	139	4	and	and	CCONJ
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gs-2738	139	6	mechanisms	mechanism	NOUN
gs-2738	139	7	underlying	underlying	ADJ
gs-2738	139	8	epileptogenesis	epileptogenesis	NOUN
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gs-2738	139	10	epilepsy	epilepsy	NOUN
gs-2738	139	11	:	:	PUNCT
gs-2738	139	12	from	from	ADP
gs-2738	139	13	pathogenesis	pathogenesis	NOUN
gs-2738	139	14	to	to	ADP
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gs-2738	139	16	target	target	NOUN
gs-2738	139	17	.	.	PUNCT
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gs-2738	140	2	.	.	PUNCT
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gs-2738	141	2	-	-	SYM
gs-2738	141	3	79	79	NUM
gs-2738	141	4	.	.	PUNCT
gs-2738	142	1	9	9	NUM
gs-2738	142	2	.	.	X
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gs-2738	142	6	-	-	PUNCT
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gs-2738	142	8	-	-	PUNCT
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gs-2738	142	11	:	:	PUNCT
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gs-2738	142	14	are	be	AUX
gs-2738	142	15	the	the	DET
gs-2738	142	16	blood	blood	NOUN
gs-2738	142	17	-	-	PUNCT
gs-2738	142	18	brain	brain	NOUN
gs-2738	142	19	barrier	barrier	NOUN
gs-2738	142	20	-	-	PUNCT
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gs-2738	142	22	pathways	pathway	NOUN
gs-2738	142	23	?	?	PUNCT
gs-2738	142	24	.	.	PUNCT
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gs-2738	143	3	.	.	PUNCT
gs-2738	144	1	2008;37(2	2008;37(2	NUM
gs-2738	144	2	-	-	PUNCT
gs-2738	144	3	3):142	3):142	NUM
gs-2738	144	4	-	-	PUNCT
gs-2738	144	5	152	152	NUM
gs-2738	144	6	.	.	PUNCT
gs-2738	145	1	10	10	NUM
gs-2738	145	2	.	.	PUNCT
gs-2738	146	1	jiang	jiang	PROPN
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gs-2738	146	3	,	,	PUNCT
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gs-2738	146	14	the	the	DET
gs-2738	146	15	prostaglandin	prostaglandin	ADJ
gs-2738	146	16	ep2	ep2	PROPN
gs-2738	146	17	receptor	receptor	NOUN
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gs-2738	146	20	-	-	PUNCT
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gs-2738	146	23	impairment	impairment	NOUN
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gs-2738	146	26	model	model	NOUN
gs-2738	146	27	of	of	ADP
gs-2738	146	28	systemic	systemic	ADJ
gs-2738	146	29	inflammation	inflammation	NOUN
gs-2738	146	30	.	.	PUNCT
gs-2738	147	1	brain	brain	NOUN
gs-2738	147	2	behav	behav	PROPN
gs-2738	147	3	immun	immun	PROPN
gs-2738	147	4	health	health	PROPN
gs-2738	147	5	.	.	PUNCT
gs-2738	148	1	2020;8:100132	2020;8:100132	NUM
gs-2738	148	2	.	.	PUNCT
gs-2738	149	1	published	publish	VERB
gs-2738	149	2	2020	2020	NUM
gs-2738	149	3	aug	aug	PROPN
gs-2738	149	4	25	25	NUM
gs-2738	149	5	11	11	NUM
gs-2738	149	6	.	.	PUNCT
gs-2738	150	1	danielski	danielski	PROPN
gs-2738	150	2	l.g	l.g	PROPN
gs-2738	150	3	.	.	PROPN
gs-2738	150	4	,	,	PUNCT
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gs-2738	150	6	a.d	a.d	PROPN
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gs-2738	150	19	-	-	PUNCT
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gs-2738	150	26	barrier	barrier	NOUN
gs-2738	150	27	breakdown	breakdown	NOUN
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gs-2738	150	30	cause	cause	NOUN
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gs-2738	150	33	of	of	ADP
gs-2738	150	34	neuroinflammation	neuroinflammation	NOUN
gs-2738	150	35	in	in	ADP
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gs-2738	151	2	.	.	PUNCT
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gs-2738	151	4	.	.	PUNCT
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gs-2738	153	4	/	/	SYM
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gs-2738	153	6	-	-	PUNCT
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gs-2738	153	8	-	-	PUNCT
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gs-2738	153	10	-	-	SYM
gs-2738	153	11	7	7	NUM
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gs-2738	153	13	.	.	PUNCT
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gs-2738	155	12	in	in	ADP
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gs-2738	156	1	dev	dev	PROPN
gs-2738	156	2	.	.	PUNCT
gs-2738	156	3	neurobiol	neurobiol	PROPN
gs-2738	156	4	.	.	PUNCT
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gs-2738	157	2	.	.	X
gs-2738	157	3	doi	doi	NOUN
gs-2738	157	4	:	:	PUNCT
gs-2738	157	5	10.1002	10.1002	NUM
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gs-2738	158	1	ganesh	ganesh	PROPN
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gs-2738	158	4	ep2	ep2	PROPN
gs-2738	158	5	receptor	receptor	NOUN
gs-2738	158	6	for	for	ADP
gs-2738	158	7	drug	drug	NOUN
gs-2738	158	8	discovery	discovery	NOUN
gs-2738	158	9	:	:	PUNCT
gs-2738	158	10	strengths	strength	NOUN
gs-2738	158	11	,	,	PUNCT
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gs-2738	158	13	,	,	PUNCT
gs-2738	158	14	opportunities	opportunity	NOUN
gs-2738	158	15	,	,	PUNCT
gs-2738	158	16	and	and	CCONJ
gs-2738	158	17	threats	threat	NOUN
gs-2738	158	18	(	(	PUNCT
gs-2738	158	19	swot	swot	PROPN
gs-2738	158	20	)	)	PUNCT
gs-2738	158	21	analysis	analysis	NOUN
gs-2738	158	22	.	.	PUNCT
gs-2738	159	1	j	j	PROPN
gs-2738	159	2	med	med	PROPN
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gs-2738	159	4	.	.	PUNCT
gs-2738	160	1	2023;66(14):9313	2023;66(14):9313	NUM
gs-2738	160	2	-	-	SYM
gs-2738	160	3	9324	9324	NUM
gs-2738	160	4	.	.	PUNCT
gs-2738	161	1	doi:10.1021	doi:10.1021	ADJ
gs-2738	161	2	/	/	SYM
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gs-2738	161	4	14	14	NUM
gs-2738	161	5	.	.	PUNCT
gs-2738	162	1	sluter	sluter	ADJ
gs-2738	162	2	m.	m.	PROPN
gs-2738	162	3	n.	n.	PROPN
gs-2738	162	4	;	;	PUNCT
gs-2738	162	5	hou	hou	PROPN
gs-2738	162	6	r.	r.	PROPN
gs-2738	162	7	;	;	PUNCT
gs-2738	162	8	li	li	PROPN
gs-2738	162	9	l.	l.	PROPN
gs-2738	162	10	;	;	PUNCT
gs-2738	162	11	yasmen	yasmen	PROPN
gs-2738	162	12	n.	n.	PROPN
gs-2738	162	13	;	;	PUNCT
gs-2738	162	14	yu	yu	PROPN
gs-2738	162	15	y.	y.	PROPN
gs-2738	162	16	;	;	PUNCT
gs-2738	162	17	liu	liu	PROPN
gs-2738	162	18	j.	j.	PROPN
gs-2738	162	19	;	;	PUNCT
gs-2738	162	20	jiang	jiang	PROPN
gs-2738	162	21	j.	j.	PROPN
gs-2738	162	22	ep2	ep2	PROPN
gs-2738	162	23	antagonists	antagonist	NOUN
gs-2738	162	24	(	(	PUNCT
gs-2738	162	25	2011–2021	2011–2021	NUM
gs-2738	162	26	):	):	PUNCT
gs-2738	162	27	a	a	DET
gs-2738	162	28	decade	decade	NOUN
gs-2738	162	29	’s	’s	PART
gs-2738	162	30	journey	journey	NOUN
gs-2738	162	31	from	from	ADP
gs-2738	162	32	discovery	discovery	NOUN
gs-2738	162	33	to	to	ADP
gs-2738	162	34	therapeutics	therapeutic	NOUN
gs-2738	162	35	.	.	PUNCT
gs-2738	163	1	j.	j.	PROPN
gs-2738	163	2	med	med	PROPN
gs-2738	163	3	.	.	PROPN
gs-2738	163	4	chem	chem	PROPN
gs-2738	163	5	.	.	PUNCT
gs-2738	164	1	2021	2021	NUM
gs-2738	164	2	,	,	PUNCT
gs-2738	164	3	64	64	NUM
gs-2738	164	4	(	(	PUNCT
gs-2738	164	5	16	16	NUM
gs-2738	164	6	)	)	PUNCT
gs-2738	164	7	,	,	PUNCT
gs-2738	164	8	11816–11836	11816–11836	NUM
gs-2738	164	9	.	.	PUNCT
gs-2738	164	10	10.1021	10.1021	NUM
gs-2738	164	11	/	/	SYM
gs-2738	164	12	acs.jmedchem.1c00816	acs.jmedchem.1c00816	PROPN
gs-2738	164	13	15	15	NUM
gs-2738	164	14	.	.	PUNCT
gs-2738	164	15	yu	yu	PROPN
gs-2738	165	1	y	y	PROPN
gs-2738	165	2	;	;	PUNCT
gs-2738	165	3	nguyen	nguyen	PROPN
gs-2738	165	4	dt	dt	PROPN
gs-2738	165	5	;	;	PUNCT
gs-2738	165	6	jiang	jiang	PROPN
gs-2738	165	7	jg	jg	PROPN
gs-2738	165	8	protein	protein	NOUN
gs-2738	165	9	-	-	PUNCT
gs-2738	165	10	coupled	couple	VERB
gs-2738	165	11	receptors	receptor	NOUN
gs-2738	165	12	in	in	ADP
gs-2738	165	13	acquired	acquire	VERB
gs-2738	165	14	epilepsy	epilepsy	NOUN
gs-2738	165	15	:	:	PUNCT
gs-2738	165	16	druggability	druggability	NOUN
gs-2738	165	17	and	and	CCONJ
gs-2738	165	18	translatability	translatability	NOUN
gs-2738	165	19	.	.	PUNCT
gs-2738	166	1	prog	prog	PROPN
gs-2738	166	2	.	.	PUNCT
gs-2738	167	1	neurobiol	neurobiol	PROPN
gs-2738	167	2	2019	2019	NUM
gs-2738	167	3	,	,	PUNCT
gs-2738	167	4	183	183	NUM
gs-2738	167	5	,	,	PUNCT
gs-2738	167	6	101682	101682	NUM
gs-2738	167	7	16	16	NUM
gs-2738	167	8	.	.	PUNCT
gs-2738	168	1	aronica	aronica	PROPN
gs-2738	168	2	e	e	PROPN
gs-2738	168	3	,	,	PUNCT
gs-2738	168	4	bauer	bauer	PROPN
gs-2738	168	5	s	s	PROPN
gs-2738	168	6	,	,	PUNCT
gs-2738	168	7	bozzi	bozzi	PROPN
gs-2738	168	8	y	y	PROPN
gs-2738	168	9	,	,	PUNCT
gs-2738	168	10	caleo	caleo	PROPN
gs-2738	168	11	m	m	PROPN
gs-2738	168	12	,	,	PUNCT
gs-2738	168	13	dingledine	dingledine	ADJ
gs-2738	168	14	r	r	NOUN
gs-2738	168	15	,	,	PUNCT
gs-2738	168	16	gorter	gorter	PROPN
gs-2738	168	17	ja	ja	PROPN
gs-2738	168	18	,	,	PUNCT
gs-2738	168	19	henshall	henshall	PROPN
gs-2738	168	20	dc	dc	PROPN
gs-2738	168	21	,	,	PUNCT
gs-2738	168	22	kaufer	kaufer	PROPN
gs-2738	168	23	d	d	PROPN
gs-2738	168	24	,	,	PUNCT
gs-2738	168	25	koh	koh	PROPN
gs-2738	168	26	s	s	PROPN
gs-2738	168	27	,	,	PUNCT
gs-2738	168	28	loscher	loscher	PROPN
gs-2738	168	29	w	w	PROPN
gs-2738	168	30	,	,	PUNCT
gs-2738	168	31	louboutin	louboutin	PROPN
gs-2738	168	32	jp	jp	PROPN
gs-2738	168	33	,	,	PUNCT
gs-2738	168	34	mishto	mishto	PROPN
gs-2738	168	35	m	m	PROPN
gs-2738	168	36	,	,	PUNCT
gs-2738	168	37	norwood	norwood	PROPN
gs-2738	168	38	ba	ba	PROPN
gs-2738	168	39	,	,	PUNCT
gs-2738	168	40	palma	palma	NOUN
gs-2738	168	41	e	e	NOUN
gs-2738	168	42	,	,	PUNCT
gs-2738	168	43	poulter	poulter	PROPN
gs-2738	168	44	mo	mo	PROPN
gs-2738	168	45	,	,	PUNCT
gs-2738	168	46	terrone	terrone	NOUN
gs-2738	168	47	g	g	NOUN
gs-2738	168	48	,	,	PUNCT
gs-2738	168	49	vezzani	vezzani	X
gs-2738	168	50	a	a	PRON
gs-2738	168	51	,	,	PUNCT
gs-2738	168	52	kaminski	kaminski	PROPN
gs-2738	168	53	rm	rm	PROPN
gs-2738	168	54	,	,	PUNCT
gs-2738	168	55	2017	2017	NUM
gs-2738	168	56	.	.	PUNCT
gs-2738	169	1	neuroinflammatory	neuroinflammatory	ADJ
gs-2738	169	2	targets	target	NOUN
gs-2738	169	3	and	and	CCONJ
gs-2738	169	4	treatments	treatment	NOUN
gs-2738	169	5	for	for	ADP
gs-2738	169	6	epilepsy	epilepsy	NOUN
gs-2738	169	7	validated	validate	VERB
gs-2738	169	8	in	in	ADP
gs-2738	169	9	experimental	experimental	ADJ
gs-2738	169	10	models	model	NOUN
gs-2738	169	11	.	.	PUNCT
gs-2738	170	1	epilepsia	epilepsia	NOUN
gs-2738	170	2	58	58	NUM
gs-2738	170	3	suppl	suppl	ADJ
gs-2738	170	4	3	3	NUM
gs-2738	170	5	,	,	PUNCT
gs-2738	170	6	27–38	27–38	NUM
gs-2738	170	7	.	.	PUNCT
gs-2738	171	1	georgian	georgian	ADJ
gs-2738	171	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-2738	171	3	მეცნიერები	მეცნიერები	NOUN
gs-2738	171	4	ტ.	ტ.	VERB
gs-2738	171	5	6	6	NUM
gs-2738	171	6	n	n	NUM
gs-2738	171	7	1	1	NUM
gs-2738	171	8	,	,	PUNCT
gs-2738	171	9	2024	2024	NUM
gs-2738	171	10	298	298	NUM
gs-2738	171	11	17	17	NUM
gs-2738	171	12	.	.	PUNCT
gs-2738	172	1	serrano	serrano	PROPN
gs-2738	172	2	ge	ge	PROPN
gs-2738	172	3	,	,	PUNCT
gs-2738	172	4	lelutiu	lelutiu	NOUN
gs-2738	172	5	n	n	PROPN
gs-2738	172	6	,	,	PUNCT
gs-2738	172	7	rojas	rojas	PROPN
gs-2738	172	8	a	a	PROPN
gs-2738	172	9	,	,	PUNCT
gs-2738	172	10	et	et	PROPN
gs-2738	172	11	al	al	PROPN
gs-2738	172	12	.	.	PUNCT
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gs-2738	172	14	of	of	ADP
gs-2738	172	15	cyclooxygenase-2	cyclooxygenase-2	NUM
gs-2738	172	16	in	in	ADP
gs-2738	172	17	forebrain	forebrain	NOUN
gs-2738	172	18	neurons	neuron	NOUN
gs-2738	172	19	is	be	AUX
gs-2738	172	20	neuroprotective	neuroprotective	ADJ
gs-2738	172	21	and	and	CCONJ
gs-2738	172	22	dampens	dampen	VERB
gs-2738	172	23	brain	brain	NOUN
gs-2738	172	24	inflammation	inflammation	NOUN
gs-2738	172	25	after	after	SCONJ
gs-2738	172	26	status	status	NOUN
gs-2738	172	27	epilepticus	epilepticus	VERB
gs-2738	172	28	.	.	PUNCT
gs-2738	173	1	j	j	PROPN
gs-2738	173	2	neurosci	neurosci	PROPN
gs-2738	173	3	.	.	PUNCT
gs-2738	174	1	2011;31:14850–14860	2011;31:14850–14860	X
gs-2738	174	2	.	.	PROPN
gs-2738	174	3	18	18	NUM
gs-2738	174	4	.	.	PUNCT
gs-2738	174	5	fattorusso	fattorusso	PROPN
gs-2738	174	6	a	a	PRON
gs-2738	174	7	,	,	PUNCT
gs-2738	174	8	matricardi	matricardi	PROPN
gs-2738	174	9	s	s	PROPN
gs-2738	174	10	,	,	PUNCT
gs-2738	174	11	mencaroni	mencaroni	PROPN
gs-2738	174	12	e	e	PROPN
gs-2738	174	13	,	,	PUNCT
gs-2738	174	14	et	et	PROPN
gs-2738	174	15	al	al	PROPN
gs-2738	174	16	.	.	PUNCT
gs-2738	175	1	the	the	DET
gs-2738	175	2	pharmacoresistant	pharmacoresistant	PROPN
gs-2738	175	3	epilepsy	epilepsy	NOUN
gs-2738	175	4	:	:	PUNCT
gs-2738	175	5	an	an	DET
gs-2738	175	6	overview	overview	NOUN
gs-2738	175	7	on	on	ADP
gs-2738	175	8	existant	existant	ADJ
gs-2738	175	9	and	and	CCONJ
gs-2738	175	10	new	new	ADJ
gs-2738	175	11	emerging	emerge	VERB
gs-2738	175	12	therapies	therapy	NOUN
gs-2738	175	13	.	.	PUNCT
gs-2738	176	1	front	front	ADJ
gs-2738	176	2	neurol	neurol	NOUN
gs-2738	176	3	.	.	PUNCT
gs-2738	177	1	2021;12:674483	2021;12:674483	X
gs-2738	177	2	.	.	PUNCT
gs-2738	177	3	published	publish	VERB
gs-2738	177	4	2021	2021	NUM
gs-2738	177	5	jun	jun	PROPN
gs-2738	177	6	22	22	NUM
gs-2738	177	7	.	.	PUNCT
gs-2738	178	1	doi:10.3389	doi:10.3389	PROPN
gs-2738	178	2	/	/	SYM
gs-2738	178	3	fneur.2021.674483	fneur.2021.674483	PROPN
gs-2738	178	4	19	19	NUM
gs-2738	178	5	.	.	PUNCT
gs-2738	178	6	physical	physical	ADJ
gs-2738	178	7	activity	activity	NOUN
gs-2738	178	8	guidelines	guideline	VERB
gs-2738	178	9	advisory	advisory	ADJ
gs-2738	178	10	committee	committee	NOUN
gs-2738	178	11	.	.	PUNCT
gs-2738	179	1	2018	2018	NUM
gs-2738	179	2	physical	physical	ADJ
gs-2738	179	3	activity	activity	NOUN
gs-2738	179	4	guidelines	guideline	NOUN
gs-2738	179	5	advisory	advisory	ADJ
gs-2738	179	6	committee	committee	NOUN
gs-2738	179	7	scientific	scientific	ADJ
gs-2738	179	8	report	report	NOUN
gs-2738	179	9	.	.	PUNCT
gs-2738	180	1	us	us	PROPN
gs-2738	180	2	department	department	PROPN
gs-2738	180	3	of	of	ADP
gs-2738	180	4	health	health	PROPN
gs-2738	180	5	and	and	CCONJ
gs-2738	180	6	human	human	PROPN
gs-2738	180	7	services	service	NOUN
gs-2738	180	8	;	;	PUNCT
gs-2738	180	9	washington	washington	PROPN
gs-2738	180	10	,	,	PUNCT
gs-2738	180	11	dc	dc	PROPN
gs-2738	180	12	,	,	PUNCT
gs-2738	180	13	usa	usa	PROPN
gs-2738	180	14	:	:	PUNCT
gs-2738	180	15	2018	2018	NUM
gs-2738	180	16	.	.	PUNCT
gs-2738	181	1	20	20	NUM
gs-2738	181	2	.	.	X
gs-2738	182	1	gakharia	gakharia	PROPN
gs-2738	182	2	,	,	PUNCT
gs-2738	182	3	t.	t.	PROPN
gs-2738	182	4	,	,	PUNCT
gs-2738	182	5	bakhtadze	bakhtadze	NOUN
gs-2738	182	6	,	,	PUNCT
gs-2738	182	7	s.	s.	PROPN
gs-2738	182	8	,	,	PUNCT
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gs-2738	182	11	m.	m.	NOUN
gs-2738	182	12	,	,	PUNCT
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gs-2738	182	14	,	,	PUNCT
gs-2738	182	15	n.	n.	NOUN
gs-2738	182	16	,	,	PUNCT
gs-2738	182	17	&	&	CCONJ
gs-2738	182	18	kapanadze	kapanadze	PROPN
gs-2738	182	19	,	,	PUNCT
gs-2738	182	20	n.	n.	PROPN
gs-2738	182	21	(	(	PUNCT
gs-2738	182	22	2022	2022	NUM
gs-2738	182	23	)	)	PUNCT
gs-2738	182	24	.	.	PUNCT
gs-2738	183	1	alterations	alteration	NOUN
gs-2738	183	2	of	of	ADP
gs-2738	183	3	plasma	plasma	NOUN
gs-2738	183	4	pro	pro	ADJ
gs-2738	183	5	-	-	ADJ
gs-2738	183	6	inflammatory	inflammatory	ADJ
gs-2738	183	7	cytokine	cytokine	NOUN
gs-2738	183	8	levels	level	NOUN
gs-2738	183	9	in	in	ADP
gs-2738	183	10	children	child	NOUN
gs-2738	183	11	with	with	ADP
gs-2738	183	12	refractory	refractory	NOUN
gs-2738	183	13	epilepsies	epilepsy	NOUN
gs-2738	183	14	.	.	PUNCT
gs-2738	184	1	children	child	NOUN
gs-2738	184	2	(	(	PUNCT
gs-2738	184	3	basel	basel	PROPN
gs-2738	184	4	,	,	PUNCT
gs-2738	184	5	switzerland	switzerland	PROPN
gs-2738	184	6	)	)	PUNCT
gs-2738	184	7	,	,	PUNCT
gs-2738	184	8	9(10	9(10	NUM
gs-2738	184	9	)	)	PUNCT
gs-2738	184	10	,	,	PUNCT
gs-2738	184	11	1506	1506	NUM
gs-2738	184	12	.	.	PUNCT
gs-2738	185	1	https://doi.org/10.3390/children9101506	https://doi.org/10.3390/children9101506	PROPN
gs-2738	185	2	21	21	NUM
gs-2738	185	3	.	.	PUNCT
gs-2738	186	1	vezzani	vezzani	PROPN
gs-2738	186	2	a	a	DET
gs-2738	186	3	,	,	PUNCT
gs-2738	186	4	french	french	PROPN
gs-2738	186	5	j	j	PROPN
gs-2738	186	6	,	,	PUNCT
gs-2738	186	7	bartfai	bartfai	PROPN
gs-2738	186	8	t	t	PROPN
gs-2738	186	9	,	,	PUNCT
gs-2738	186	10	baram	baram	PROPN
gs-2738	186	11	tz	tz	PROPN
gs-2738	186	12	.	.	PUNCT
gs-2738	187	1	the	the	DET
gs-2738	187	2	role	role	NOUN
gs-2738	187	3	of	of	ADP
gs-2738	187	4	inflammation	inflammation	NOUN
gs-2738	187	5	in	in	ADP
gs-2738	187	6	epilepsy	epilepsy	PROPN
gs-2738	187	7	.	.	PUNCT
gs-2738	188	1	nat	nat	PROPN
gs-2738	188	2	rev	rev	VERB
gs-2738	188	3	neurol	neurol	PROPN
gs-2738	188	4	.	.	PUNCT
gs-2738	189	1	2011;7(1):31	2011;7(1):31	NUM
gs-2738	189	2	-	-	SYM
gs-2738	189	3	40	40	NUM
gs-2738	189	4	.	.	PUNCT
gs-2738	189	5	doi:10.1038	doi:10.1038	NOUN
gs-2738	189	6	/	/	SYM
gs-2738	189	7	nrneurol.2010.178	nrneurol.2010.178	PROPN
gs-2738	189	8	22	22	NUM
gs-2738	189	9	.	.	PUNCT
gs-2738	190	1	xin	xin	PROPN
gs-2738	190	2	y	y	PROPN
gs-2738	190	3	,	,	PUNCT
gs-2738	190	4	tian	tian	PROPN
gs-2738	190	5	m	m	PROPN
gs-2738	190	6	,	,	PUNCT
gs-2738	190	7	deng	deng	PROPN
gs-2738	190	8	s	s	PROPN
gs-2738	190	9	,	,	PUNCT
gs-2738	190	10	et	et	PROPN
gs-2738	190	11	al	al	PROPN
gs-2738	190	12	.	.	PUNCT
gs-2738	191	1	the	the	DET
gs-2738	191	2	key	key	ADJ
gs-2738	191	3	drivers	driver	NOUN
gs-2738	191	4	of	of	ADP
gs-2738	191	5	brain	brain	NOUN
gs-2738	191	6	injury	injury	NOUN
gs-2738	191	7	by	by	ADP
gs-2738	191	8	systemic	systemic	ADJ
gs-2738	191	9	inflammatory	inflammatory	ADJ
gs-2738	191	10	responses	response	NOUN
gs-2738	191	11	after	after	ADP
gs-2738	191	12	sepsis	sepsis	NOUN
gs-2738	191	13	:	:	PUNCT
gs-2738	191	14	microglia	microglia	NOUN
gs-2738	191	15	and	and	CCONJ
gs-2738	191	16	neuroinflammation	neuroinflammation	NOUN
gs-2738	191	17	.	.	PUNCT
gs-2738	192	1	mol	mol	ADP
gs-2738	192	2	neurobiol	neurobiol	PROPN
gs-2738	192	3	.	.	PUNCT
gs-2738	193	1	2023;60(3):1369	2023;60(3):1369	NUM
gs-2738	193	2	-	-	SYM
gs-2738	193	3	1390	1390	NUM
gs-2738	193	4	.	.	PUNCT
gs-2738	194	1	doi:10.1007	doi:10.1007	VERB
gs-2738	194	2	/	/	SYM
gs-2738	194	3	s12035	s12035	PROPN
gs-2738	194	4	-	-	PUNCT
gs-2738	194	5	022	022	NUM
gs-2738	194	6	-	-	PUNCT
gs-2738	194	7	03148	03148	NUM
gs-2738	194	8	-	-	PUNCT
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gs-2738	195	5	n	n	CCONJ
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gs-2738	196	2	,	,	PUNCT
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gs-2738	196	4	i	i	PROPN
gs-2738	196	5	,	,	PUNCT
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gs-2738	196	11	e2	e2	NOUN
gs-2738	196	12	(	(	PUNCT
gs-2738	196	13	pge2)targeting	pge2)targete	VERB
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gs-2738	196	16	probes	probe	NOUN
gs-2738	196	17	from	from	ADP
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gs-2738	197	5	.	.	PUNCT
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gs-2738	198	2	.	.	PUNCT
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gs-2738	199	5	.	.	PUNCT
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gs-2738	199	7	/	/	SYM
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gs-2738	199	10	.	.	PUNCT
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gs-2738	200	3	,	,	PUNCT
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gs-2738	200	16	dingledine	dingledine	ADJ
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gs-2738	200	20	.	.	PUNCT
gs-2738	201	1	inhibition	inhibition	NOUN
gs-2738	201	2	of	of	ADP
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gs-2738	201	5	receptor	receptor	NOUN
gs-2738	201	6	ep2	ep2	NOUN
gs-2738	201	7	following	follow	VERB
gs-2738	201	8	status	status	NOUN
gs-2738	201	9	epilepticus	epilepticus	NOUN
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gs-2738	201	14	brain	brain	NOUN
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gs-2738	201	16	.	.	PUNCT
gs-2738	202	1	proc	proc	PROPN
gs-2738	202	2	.	.	PUNCT
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gs-2738	203	2	.	.	PUNCT
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gs-2738	204	2	.	.	PUNCT
gs-2738	205	1	sci	sci	PROPN
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gs-2738	205	3	u.	u.	PROPN
gs-2738	205	4	s.	s.	PROPN
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gs-2738	205	6	110	110	NUM
gs-2738	205	7	,	,	PUNCT
gs-2738	205	8	3591–3596	3591–3596	NUM
gs-2738	205	9	.	.	PUNCT
gs-2738	206	1	25	25	NUM
gs-2738	206	2	.	.	PUNCT
gs-2738	206	3	yu	yu	PROPN
gs-2738	206	4	y	y	PROPN
gs-2738	206	5	,	,	PUNCT
gs-2738	206	6	jiang	jiang	PROPN
gs-2738	206	7	j.	j.	PROPN
gs-2738	206	8	cox-2	cox-2	PROPN
gs-2738	206	9	/	/	SYM
gs-2738	206	10	pge2	pge2	NOUN
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gs-2738	206	12	regulates	regulate	VERB
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gs-2738	206	18	via	via	ADP
gs-2738	206	19	ep2	ep2	PROPN
gs-2738	206	20	receptor	receptor	NOUN
gs-2738	206	21	after	after	ADP
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gs-2738	206	23	seizures	seizure	NOUN
gs-2738	206	24	.	.	PUNCT
gs-2738	207	1	epilepsia	epilepsia	NOUN
gs-2738	207	2	open	open	NOUN
gs-2738	207	3	.	.	PUNCT
gs-2738	208	1	2020;5(3):418	2020;5(3):418	NUM
gs-2738	208	2	-	-	SYM
gs-2738	208	3	431	431	NUM
gs-2738	208	4	.	.	PUNCT
gs-2738	209	1	published	publish	VERB
gs-2738	209	2	2020	2020	NUM
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gs-2738	209	5	.	.	PUNCT
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gs-2738	209	7	/	/	SYM
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gs-2738	209	10	.	.	PUNCT
gs-2738	210	1	ximenes	ximenes	PROPN
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gs-2738	210	3	,	,	PUNCT
gs-2738	210	4	de	de	PROPN
gs-2738	210	5	oliveira	oliveira	PROPN
gs-2738	210	6	gonçalves	gonçalves	PROPN
gs-2738	210	7	d	d	PROPN
gs-2738	210	8	,	,	PUNCT
gs-2738	210	9	siqueira	siqueira	PROPN
gs-2738	210	10	rm	rm	PROPN
gs-2738	210	11	,	,	PUNCT
gs-2738	210	12	et	et	PROPN
gs-2738	210	13	al	al	PROPN
gs-2738	210	14	.	.	PUNCT
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gs-2738	210	17	:	:	PUNCT
gs-2738	210	18	an	an	DET
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gs-2738	210	21	with	with	ADP
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gs-2738	210	24	and	and	CCONJ
gs-2738	210	25	anti	anti	ADJ
gs-2738	210	26	-	-	ADJ
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gs-2738	210	28	properties	property	NOUN
gs-2738	210	29	.	.	PUNCT
gs-2738	211	1	naunyn	naunyn	PROPN
gs-2738	211	2	schmiedebergs	schmiedebergs	PROPN
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gs-2738	211	5	.	.	PUNCT
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gs-2738	212	2	-	-	SYM
gs-2738	212	3	587	587	NUM
gs-2738	212	4	.	.	PUNCT
gs-2738	213	1	doi:10.1007	doi:10.1007	VERB
gs-2738	213	2	/	/	SYM
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gs-2738	213	4	-	-	PUNCT
gs-2738	213	5	013	013	NUM
gs-2738	213	6	-	-	PUNCT
gs-2738	213	7	0853	0853	NUM
gs-2738	213	8	-	-	SYM
gs-2738	213	9	4	4	NUM
gs-2738	213	10	27	27	NUM
gs-2738	213	11	.	.	PUNCT
gs-2738	214	1	45	45	NUM
gs-2738	214	2	.	.	NOUN
gs-2738	214	3	ichiyama	ichiyama	PROPN
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gs-2738	214	5	,	,	PUNCT
gs-2738	214	6	okada	okada	PROPN
gs-2738	214	7	k	k	PROPN
gs-2738	214	8	,	,	PUNCT
gs-2738	214	9	lipton	lipton	PROPN
gs-2738	214	10	jm	jm	PROPN
gs-2738	214	11	,	,	PUNCT
gs-2738	214	12	matsubara	matsubara	PROPN
gs-2738	214	13	t	t	PROPN
gs-2738	214	14	,	,	PUNCT
gs-2738	214	15	hayashi	hayashi	PROPN
gs-2738	214	16	t	t	PROPN
gs-2738	214	17	,	,	PUNCT
gs-2738	214	18	furukawa	furukawa	PROPN
gs-2738	214	19	s.	s.	PROPN
gs-2738	214	20	sodium	sodium	PROPN
gs-2738	214	21	valproate	valproate	PROPN
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gs-2738	214	23	production	production	NOUN
gs-2738	214	24	of	of	ADP
gs-2738	214	25	tnf	tnf	PROPN
gs-2738	214	26	-	-	PUNCT
gs-2738	214	27	alpha	alpha	NOUN
gs-2738	214	28	and	and	CCONJ
gs-2738	214	29	il-6	il-6	NOUN
gs-2738	214	30	and	and	CCONJ
gs-2738	214	31	activation	activation	NOUN
gs-2738	214	32	of	of	ADP
gs-2738	214	33	nf	nf	NOUN
gs-2738	214	34	-	-	PUNCT
gs-2738	214	35	kappab	kappab	NOUN
gs-2738	214	36	.	.	PUNCT
gs-2738	215	1	brain	brain	NOUN
gs-2738	215	2	res	re	NOUN
gs-2738	215	3	.	.	PUNCT
gs-2738	216	1	2000;857(12):246	2000;857(12):246	NUM
gs-2738	216	2	-	-	SYM
gs-2738	216	3	251	251	NUM
gs-2738	216	4	.	.	PUNCT
gs-2738	216	5	doi:10.1016	doi:10.1016	PROPN
gs-2738	216	6	/	/	SYM
gs-2738	216	7	s0006	s0006	NUM
gs-2738	216	8	-	-	PUNCT
gs-2738	216	9	8993(99)02439	8993(99)02439	NUM
gs-2738	216	10	-	-	PUNCT
gs-2738	216	11	7	7	NUM
gs-2738	216	12	28	28	NUM
gs-2738	216	13	.	.	PUNCT
gs-2738	217	1	rawat	rawat	PROPN
gs-2738	217	2	c	c	PROPN
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gs-2738	217	6	,	,	PUNCT
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gs-2738	217	8	s	s	PROPN
gs-2738	217	9	,	,	PUNCT
gs-2738	217	10	et	et	PROPN
gs-2738	217	11	al	al	PROPN
gs-2738	217	12	.	.	PUNCT
gs-2738	218	1	downregulation	downregulation	NOUN
gs-2738	218	2	of	of	ADP
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gs-2738	218	4	ptgs2	ptgs2	NOUN
gs-2738	218	5	/	/	SYM
gs-2738	218	6	cox-2	cox-2	NOUN
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gs-2738	218	9	to	to	ADP
gs-2738	218	10	valproate	valproate	ADJ
gs-2738	218	11	treatment	treatment	NOUN
gs-2738	218	12	in	in	ADP
gs-2738	218	13	patients	patient	NOUN
gs-2738	218	14	with	with	ADP
gs-2738	218	15	epilepsy	epilepsy	NOUN
gs-2738	218	16	.	.	PUNCT
gs-2738	219	1	sci	sci	PROPN
gs-2738	219	2	rep	rep	PROPN
gs-2738	219	3	.	.	PROPN
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gs-2738	219	5	.	.	PUNCT
gs-2738	220	1	published	publish	VERB
gs-2738	220	2	2020	2020	NUM
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gs-2738	220	4	13	13	NUM
gs-2738	220	5	.	.	PUNCT
gs-2738	221	1	doi:10.1038	doi:10.1038	NOUN
gs-2738	221	2	/	/	SYM
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gs-2738	221	4	-	-	PUNCT
gs-2738	221	5	020	020	NUM
gs-2738	221	6	-	-	PUNCT
gs-2738	221	7	59259	59259	NUM
gs-2738	221	8	-	-	PUNCT
gs-2738	221	9	x	x	SYM
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gs-2738	221	11	.	.	PUNCT
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gs-2738	222	2	w	w	PROPN
gs-2738	222	3	,	,	PUNCT
gs-2738	222	4	potschka	potschka	PROPN
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gs-2738	222	14	in	in	ADP
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gs-2738	222	16	:	:	PUNCT
gs-2738	222	17	clinical	clinical	ADJ
gs-2738	222	18	impact	impact	NOUN
gs-2738	222	19	,	,	PUNCT
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gs-2738	222	21	mechanisms	mechanism	NOUN
gs-2738	222	22	,	,	PUNCT
gs-2738	222	23	and	and	CCONJ
gs-2738	222	24	new	new	ADJ
gs-2738	222	25	innovative	innovative	ADJ
gs-2738	222	26	treatment	treatment	NOUN
gs-2738	222	27	options	option	NOUN
gs-2738	222	28	.	.	PUNCT
gs-2738	223	1	pharmacol	pharmacol	PROPN
gs-2738	223	2	rev	rev	PROPN
gs-2738	223	3	.	.	PUNCT
gs-2738	224	1	2020;72(3):606638	2020;72(3):606638	NUM
gs-2738	224	2	.	.	PUNCT
gs-2738	225	1	doi:10.1124	doi:10.1124	NOUN
gs-2738	225	2	/	/	SYM
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gs-2738	226	4	მეცნიერები	მეცნიერები	NOUN
gs-2738	226	5	ტ.	ტ.	VERB
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gs-2738	226	8	1	1	NUM
gs-2738	226	9	,	,	PUNCT
gs-2738	226	10	2024	2024	NUM
gs-2738	226	11	299	299	NUM
gs-2738	226	12	30	30	NUM
gs-2738	226	13	.	.	PUNCT
gs-2738	227	1	miller	miller	PROPN
gs-2738	227	2	ds	ds	PROPN
gs-2738	227	3	,	,	PUNCT
gs-2738	227	4	bauer	bauer	PROPN
gs-2738	227	5	b	b	PROPN
gs-2738	227	6	,	,	PUNCT
gs-2738	227	7	hartz	hartz	PROPN
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gs-2738	227	11	of	of	ADP
gs-2738	227	12	p	p	NOUN
gs-2738	227	13	-	-	PUNCT
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gs-2738	227	15	at	at	ADP
gs-2738	227	16	the	the	DET
gs-2738	227	17	blood	blood	NOUN
gs-2738	227	18	-	-	PUNCT
gs-2738	227	19	brain	brain	NOUN
gs-2738	227	20	barrier	barrier	NOUN
gs-2738	227	21	:	:	PUNCT
gs-2738	227	22	opportunities	opportunity	NOUN
gs-2738	227	23	to	to	PART
gs-2738	227	24	improve	improve	VERB
gs-2738	227	25	central	central	ADJ
gs-2738	227	26	nervous	nervous	ADJ
gs-2738	227	27	system	system	NOUN
gs-2738	227	28	pharmacotherapy	pharmacotherapy	NOUN
gs-2738	227	29	.	.	PUNCT
gs-2738	228	1	pharmacol	pharmacol	PROPN
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gs-2738	228	3	.	.	PUNCT
gs-2738	229	1	2008;60(2):196	2008;60(2):196	NUM
gs-2738	229	2	-	-	SYM
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gs-2738	229	4	.	.	PUNCT
gs-2738	230	1	doi:10.1124	doi:10.1124	NOUN
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gs-2738	230	4	31	31	NUM
gs-2738	230	5	.	.	PUNCT
gs-2738	231	1	rawat	rawat	PROPN
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gs-2738	231	3	,	,	PUNCT
gs-2738	231	4	kukal	kukal	PROPN
gs-2738	231	5	s	s	PROPN
gs-2738	231	6	,	,	PUNCT
gs-2738	231	7	dahiya	dahiya	NOUN
gs-2738	231	8	ur	ur	INTJ
gs-2738	231	9	,	,	PUNCT
gs-2738	231	10	kukreti	kukreti	PROPN
gs-2738	231	11	r.	r.	PROPN
gs-2738	231	12	cyclooxygenase-2	cyclooxygenase-2	NUM
gs-2738	231	13	(	(	PUNCT
gs-2738	231	14	cox-2	cox-2	NOUN
gs-2738	231	15	)	)	PUNCT
gs-2738	231	16	inhibitors	inhibitor	NOUN
gs-2738	231	17	:	:	PUNCT
gs-2738	231	18	future	future	ADJ
gs-2738	231	19	therapeutic	therapeutic	ADJ
gs-2738	231	20	strategies	strategy	NOUN
gs-2738	231	21	for	for	ADP
gs-2738	231	22	epilepsy	epilepsy	NOUN
gs-2738	231	23	management	management	NOUN
gs-2738	231	24	.	.	PUNCT
gs-2738	232	1	j	j	PROPN
gs-2738	232	2	neuroinflammation	neuroinflammation	PROPN
gs-2738	232	3	.	.	PUNCT
gs-2738	233	1	2019;16(1):197	2019;16(1):197	NUM
gs-2738	233	2	.	.	PUNCT
gs-2738	234	1	published	publish	VERB
gs-2738	234	2	2019	2019	NUM
gs-2738	234	3	oct	oct	NOUN
gs-2738	234	4	30	30	NUM
gs-2738	234	5	.	.	PUNCT
gs-2738	235	1	doi:10.1186	doi:10.1186	PROPN
gs-2738	235	2	/	/	SYM
gs-2738	235	3	s12974	s12974	NOUN
gs-2738	235	4	-	-	PUNCT
gs-2738	235	5	019	019	NUM
gs-2738	235	6	-	-	PUNCT
gs-2738	235	7	1592	1592	NUM
gs-2738	235	8	-	-	SYM
gs-2738	235	9	3	3	NUM
gs-2738	235	10	32	32	NUM
gs-2738	235	11	.	.	PUNCT
gs-2738	236	1	rawat	rawat	PROPN
gs-2738	236	2	c	c	PROPN
gs-2738	236	3	,	,	PUNCT
gs-2738	236	4	shivangi	shivangi	PROPN
gs-2738	236	5	,	,	PUNCT
gs-2738	236	6	kushwaha	kushwaha	PROPN
gs-2738	236	7	s	s	PROPN
gs-2738	236	8	,	,	PUNCT
gs-2738	236	9	sharma	sharma	PROPN
gs-2738	236	10	s	s	PROPN
gs-2738	236	11	,	,	PUNCT
gs-2738	236	12	srivastava	srivastava	PROPN
gs-2738	236	13	ak	ak	PROPN
gs-2738	236	14	,	,	PUNCT
gs-2738	236	15	kukreti	kukreti	PROPN
gs-2738	236	16	r.	r.	PROPN
gs-2738	236	17	altered	alter	VERB
gs-2738	236	18	plasma	plasma	NOUN
gs-2738	236	19	prostaglandin	prostaglandin	PROPN
gs-2738	236	20	e2	e2	PROPN
gs-2738	236	21	levels	level	NOUN
gs-2738	236	22	in	in	ADP
gs-2738	236	23	epilepsy	epilepsy	NOUN
gs-2738	236	24	and	and	CCONJ
gs-2738	236	25	in	in	ADP
gs-2738	236	26	response	response	NOUN
gs-2738	236	27	to	to	ADP
gs-2738	236	28	antiepileptic	antiepileptic	ADJ
gs-2738	236	29	drug	drug	NOUN
gs-2738	236	30	monotherapy	monotherapy	NOUN
gs-2738	236	31	.	.	PUNCT
gs-2738	237	1	prostaglandins	prostaglandin	NOUN
gs-2738	237	2	leukot	leukot	VERB
gs-2738	237	3	essent	essent	ADJ
gs-2738	237	4	fatty	fatty	NOUN
gs-2738	237	5	acids	acid	NOUN
gs-2738	237	6	.	.	PUNCT
gs-2738	238	1	2020;153:102056	2020;153:102056	NUM
gs-2738	238	2	.	.	PUNCT
gs-2738	238	3	doi:10.1016	doi:10.1016	PROPN
gs-2738	238	4	/	/	SYM
gs-2738	238	5	j.plefa.2020.102056	j.plefa.2020.102056	PROPN
gs-2738	238	6	აბსტრაქტი	აბსტრაქტი	NOUN
gs-2738	238	7	ეპილეფსია	ეპილეფსია	ADJ
gs-2738	238	8	ბავშვთა	ბავშვთა	PROPN
gs-2738	238	9	ასაკში	ასაკში	ADJ
gs-2738	238	10	წარმოადგენს	წარმოადგენს	ADJ
gs-2738	238	11	ნევროლოგიურად	ნევროლოგიურად	PROPN
gs-2738	238	12	ჰეტეროგენურ	ჰეტეროგენურ	PROPN
gs-2738	238	13	ჯგუფს	ჯგუფს	PROPN
gs-2738	238	14	,	,	PUNCT
gs-2738	238	15	რომელსაც	რომელსაც	PROPN
gs-2738	238	16	აქვს	აქვს	PROPN
gs-2738	238	17	მულტიფაქტორული	მულტიფაქტორული	PROPN
gs-2738	238	18	ეტიოლოგია	ეტიოლოგია	NOUN
gs-2738	238	19	და	და	NOUN
gs-2738	238	20	ხასიათდება	ხასიათდება	NOUN
gs-2738	238	21	სხვადასხვა	სხვადასხვა	PROPN
gs-2738	238	22	კლინიკური	კლინიკური	PROPN
gs-2738	238	23	მიმდინარეობით.	მიმდინარეობით.	VERB
gs-2738	238	24	ახალი	ახალი	ADJ
gs-2738	238	25	გულყრის	გულყრის	PROPN
gs-2738	238	26	საწინააღმდეგო	საწინააღმდეგო	PROPN
gs-2738	238	27	მედიკამენტების	მედიკამენტების	ADJ
gs-2738	238	28	შექმნის	შექმნის	PROPN
gs-2738	238	29	მიუხედავად	მიუხედავად	PROPN
gs-2738	238	30	,	,	PUNCT
gs-2738	238	31	მკურნალობის	მკურნალობის	NOUN
gs-2738	238	32	მნიშვნელოვან	მნიშვნელოვან	ADJ
gs-2738	238	33	დაბრკოლებად	დაბრკოლებად	PROPN
gs-2738	238	34	წამლისადმი	წამლისადმი	PROPN
gs-2738	238	35	რეზისტენტობა	რეზისტენტობა	PROPN
gs-2738	238	36	რჩება.	რჩება.	PROPN
gs-2738	239	1	მზარდია	მზარდია	ADJ
gs-2738	239	2	მტკიცებულებები	მტკიცებულებები	NOUN
gs-2738	239	3	ეპილეფსიის	ეპილეფსიის	VERB
gs-2738	239	4	ანთებით	ანთებით	NOUN
gs-2738	239	5	პროცესებთან	პროცესებთან	PROPN
gs-2738	239	6	კავშირის	კავშირის	PROPN
gs-2738	239	7	შესახებ	შესახებ	VERB
gs-2738	239	8	,	,	PUNCT
gs-2738	239	9	განსაკუთრებით	განსაკუთრებით	PROPN
gs-2738	239	10	წამლებისადმი	წამლებისადმი	ADV
gs-2738	239	11	რეზისტენტული	რეზისტენტული	PROPN
gs-2738	239	12	ფორმების	ფორმების	PROPN
gs-2738	239	13	შემთხვევებში.	შემთხვევებში.	VERB
gs-2738	240	1	რეზისტენტული	რეზისტენტული	PROPN
gs-2738	240	2	ეპილეფსიის	ეპილეფსიის	PROPN
gs-2738	240	3	პათოგენეზში	პათოგენეზში	ADJ
gs-2738	240	4	შესწავლილია	შესწავლილია	ADJ
gs-2738	240	5	ნეიროანთებითი	ნეიროანთებითი	NOUN
gs-2738	240	6	გზები	გზები	NOUN
gs-2738	240	7	და	და	VERB
gs-2738	240	8	ციტოკინების	ციტოკინების	ADJ
gs-2738	240	9	როლი	როლი	NOUN
gs-2738	240	10	,	,	PUNCT
gs-2738	240	11	მათ	მათ	NOUN
gs-2738	240	12	შორის	შორის	NOUN
gs-2738	240	13	,	,	PUNCT
gs-2738	240	14	ერთ-ერთი	ერთ-ერთი	ADJ
gs-2738	240	15	მნიშვნელოვანი	მნიშვნელოვანი	NOUN
gs-2738	240	16	რგოლია	რგოლია	ADJ
gs-2738	240	17	cox2	cox2	PROPN
gs-2738	240	18	-	-	PUNCT
gs-2738	240	19	pge2-პროსტაგლანდინ	pge2-პროსტაგლანდინ	PROPN
gs-2738	240	20	e2	e2	PROPN
gs-2738	240	21	რეცეპტორ	რეცეპტორ	PROPN
gs-2738	240	22	1-ის	1-ის	NUM
gs-2738	240	23	ღერძი	ღერძი	NOUN
gs-2738	240	24	,	,	PUNCT
gs-2738	240	25	რომელიც	რომელიც	ADJ
gs-2738	240	26	გავლენას	გავლენას	PROPN
gs-2738	240	27	ახდენს	ახდენს	PROPN
gs-2738	240	28	ჰემატოენცეფალური	ჰემატოენცეფალური	PROPN
gs-2738	240	29	ბარიერის	ბარიერის	NOUN
gs-2738	240	30	ფუნქციონირებაზე	ფუნქციონირებაზე	NOUN
gs-2738	240	31	და	და	PROPN
gs-2738	240	32	ასევე	ასევე	PROPN
gs-2738	240	33	უშუალოდ	უშუალოდ	PROPN
gs-2738	240	34	წამლის	წამლის	VERB
gs-2738	240	35	ფარმაკოკინეტიკაზე	ფარმაკოკინეტიკაზე	NOUN
gs-2738	240	36	,	,	PUNCT
gs-2738	240	37	პლაზმურ	პლაზმურ	PROPN
gs-2738	240	38	მემბრანიდან	მემბრანიდან	PROPN
gs-2738	240	39	მედიკამენტების	მედიკამენტების	PROPN
gs-2738	240	40	გამომფრქვევზე	გამომფრქვევზე	PROPN
gs-2738	240	41	ზემოქმედების	ზემოქმედების	ADV
gs-2738	240	42	რეგულაციის	რეგულაციის	PROPN
gs-2738	240	43	გზით	გზით	PROPN
gs-2738	240	44	.	.	PUNCT
gs-2738	241	1	კვლევის	კვლევის	NOUN
gs-2738	241	2	ფარგლებში	ფარგლებში	PROPN
gs-2738	241	3	,	,	PUNCT
gs-2738	241	4	სისხლის	სისხლის	PROPN
gs-2738	241	5	შრატში	შრატში	PROPN
gs-2738	241	6	განისაზღვრა	განისაზღვრა	PROPN
gs-2738	241	7	pge2	pge2	PROPN
gs-2738	241	8	დონეები	დონეები	PROPN
gs-2738	241	9	სხვადასხვა	სხვადასხვა	PROPN
gs-2738	241	10	ტიპის	ტიპის	NOUN
gs-2738	241	11	ეპილეფსიის	ეპილეფსიის	PROPN
gs-2738	241	12	მქონე	მქონე	PROPN
gs-2738	241	13	პაციენტებისთვის	პაციენტებისთვის	PROPN
gs-2738	241	14	,	,	PUNCT
gs-2738	241	15	რათა	რათა	PROPN
gs-2738	241	16	შეფასებულიყო	შეფასებულიყო	VERB
gs-2738	241	17	pge2	pge2	NOUN
gs-2738	241	18	მნიშვნელობა	მნიშვნელობა	NOUN
gs-2738	241	19	ეპილეფსიასთან	ეპილეფსიასთან	PROPN
gs-2738	241	20	ასოცირებულ	ასოცირებულ	PROPN
gs-2738	241	21	ანთებასა	ანთებასა	ADJ
gs-2738	241	22	და	და	PROPN
gs-2738	241	23	ანტიეპილეფსიური	ანტიეპილეფსიური	PROPN
gs-2738	241	24	წამლით	წამლით	PROPN
gs-2738	241	25	მკურნალობის	მკურნალობის	NOUN
gs-2738	241	26	ეფექტურობაში	ეფექტურობაში	NOUN
gs-2738	241	27	.	.	PUNCT
gs-2738	242	1	მეთოდები	მეთოდები	NOUN
gs-2738	242	2	:	:	PUNCT
gs-2738	242	3	კლინიკური	კლინიკური	PROPN
gs-2738	242	4	და	და	PROPN
gs-2738	242	5	პარაკლინიკური	პარაკლინიკური	PROPN
gs-2738	242	6	მონაცემების	მონაცემების	PROPN
gs-2738	242	7	პერსპექტული	პერსპექტული	PROPN
gs-2738	242	8	ანალიზი	ანალიზი	PROPN
gs-2738	242	9	,	,	PUNCT
gs-2738	242	10	საკვლევი	საკვლევი	NOUN
gs-2738	242	11	ჯგუფი	ჯგუფი	VERB
gs-2738	242	12	1	1	NUM
gs-2738	242	13	a-პაციენტები	a-პაციენტები	NOUN
gs-2738	242	14	ეპილეფსიის	ეპილეფსიის	VERB
gs-2738	242	15	დიაგნოზით	დიაგნოზით	ADJ
gs-2738	242	16	რომლებიც	რომლებიც	PROPN
gs-2738	242	17	იტარებდნენ	იტარებდნენ	PROPN
gs-2738	242	18	ანტიეპილეფსიურ	ანტიეპილეფსიურ	NOUN
gs-2738	242	19	მკურნალობას	მკურნალობას	NOUN
gs-2738	242	20	,	,	PUNCT
gs-2738	242	21	მიმდინარე	მიმდინარე	ADJ
gs-2738	242	22	გულყრების	გულყრების	ADJ
gs-2738	242	23	გარეშე	გარეშე	NOUN
gs-2738	242	24	,	,	PUNCT
gs-2738	242	25	ჯგუფი	ჯგუფი	VERB
gs-2738	242	26	1bპაციენტები	1bპაციენტები	NUM
gs-2738	242	27	წამალრეზისტენტული	წამალრეზისტენტული	X
gs-2738	242	28	ეპილეფსიით	ეპილეფსიით	ADJ
gs-2738	242	29	,	,	PUNCT
gs-2738	242	30	ინტერიქტულ	ინტერიქტულ	ADJ
gs-2738	242	31	პერიოდში	პერიოდში	NOUN
gs-2738	242	32	;	;	PUNCT
gs-2738	242	33	საკონტროლო	საკონტროლო	NOUN
gs-2738	242	34	ჯგუფი	ჯგუფი	VERB
gs-2738	242	35	2	2	NUM
gs-2738	242	36	ჯანმრთელ	ჯანმრთელ	NOUN
gs-2738	242	37	ბავშვები.	ბავშვები.	PROPN
gs-2738	242	38	შრატში	შრატში	PROPN
gs-2738	242	39	pge2	pge2	PROPN
gs-2738	242	40	რაოდენობივი	რაოდენობივი	PROPN
gs-2738	242	41	დონის	დონის	PROPN
gs-2738	242	42	(	(	PUNCT
gs-2738	242	43	კვარტლთაშორისი	კვარტლთაშორისი	ADJ
gs-2738	242	44	დიაპაზონი/პგ/მლ	დიაპაზონი/პგ/მლ	NOUN
gs-2738	242	45	)	)	PUNCT
gs-2738	242	46	განსაზღვრა	განსაზღვრა	VERB
gs-2738	242	47	ფერმენტთან	ფერმენტთან	NOUN
gs-2738	242	48	დაკავშირებული	დაკავშირებული	NOUN
gs-2738	242	49	იმუნოსორბენტული	იმუნოსორბენტული	PROPN
gs-2738	242	50	ანალიზით	ანალიზით	PROPN
gs-2738	242	51	(	(	PUNCT
gs-2738	242	52	elisa	elisa	PROPN
gs-2738	242	53	)	)	PUNCT
gs-2738	242	54	.	.	PUNCT
gs-2738	243	1	შედეგები	შედეგები	NOUN
gs-2738	243	2	:	:	PUNCT
gs-2738	243	3	შრატის	შრატის	NOUN
gs-2738	243	4	pge2	pge2	VERB
gs-2738	243	5	მედიანური	მედიანური	PROPN
gs-2738	243	6	ინტერკვარტილური	ინტერკვარტილური	PROPN
gs-2738	243	7	დიაპაზონი	დიაპაზონი	PROPN
gs-2738	243	8	(	(	PUNCT
gs-2738	243	9	iqr	iqr	NOUN
gs-2738	243	10	)	)	PUNCT
gs-2738	243	11	უფრო	უფრო	PROPN
gs-2738	243	12	ფართო	ფართო	PROPN
gs-2738	243	13	დიაპაზონში	დიაპაზონში	ADJ
gs-2738	243	14	მერყეობდა	მერყეობდა	PROPN
gs-2738	243	15	და	და	PROPN
gs-2738	243	16	მეტად	მეტად	NOUN
gs-2738	243	17	იყო	იყო	VERB
gs-2738	243	18	მომატებული	მომატებული	PROPN
gs-2738	243	19	ეპილეფსიის	ეპილეფსიის	PROPN
gs-2738	243	20	მქონე	მქონე	PROPN
gs-2738	243	21	პაციენტებიში	პაციენტებიში	PROPN
gs-2738	243	22	512	512	NUM
gs-2738	243	23	პგ/მლ	პგ/მლ	NUM
gs-2738	243	24	(	(	PUNCT
gs-2738	243	25	324.5	324.5	NUM
gs-2738	243	26	-	-	SYM
gs-2738	243	27	970.0	970.0	NUM
gs-2738	243	28	)	)	PUNCT
gs-2738	243	29	ჯანმრთელ	ჯანმრთელ	NOUN
gs-2738	243	30	კონტროლთან	კონტროლთან	ADV
gs-2738	243	31	შედარებით	შედარებით	VERB
gs-2738	243	32	406	406	NUM
gs-2738	243	33	პგ/მლ	პგ/მლ	NUM
gs-2738	243	34	(	(	PUNCT
gs-2738	243	35	278.7	278.7	NUM
gs-2738	243	36	-	-	SYM
gs-2738	243	37	541.4	541.4	NUM
gs-2738	243	38	)	)	PUNCT
gs-2738	243	39	,	,	PUNCT
gs-2738	243	40	თუმცა	თუმცა	ADP
gs-2738	243	41	,	,	PUNCT
gs-2738	243	42	georgian	georgian	ADJ
gs-2738	243	43	scientists/ქართველი	scientists/ქართველი	NOUN
gs-2738	243	44	მეცნიერები	მეცნიერები	NOUN
gs-2738	243	45	ტ.	ტ.	VERB
gs-2738	243	46	6	6	NUM
gs-2738	243	47	n	n	NUM
gs-2738	243	48	1	1	NUM
gs-2738	243	49	,	,	PUNCT
gs-2738	243	50	2024	2024	NUM
gs-2738	243	51	300	300	NUM
gs-2738	243	52	მონაცემები	მონაცემები	NOUN
gs-2738	243	53	მნიშვნელოვნად	მნიშვნელოვნად	NOUN
gs-2738	243	54	არ	არ	AUX
gs-2738	243	55	განსხვავდებოდა	განსხვავდებოდა	VERB
gs-2738	243	56	ეპილეფსიის	ეპილეფსიის	PROPN
gs-2738	243	57	დიაგნოზის	დიაგნოზის	PROPN
gs-2738	243	58	მქონეთა	მქონეთა	PROPN
gs-2738	243	59	ქვეჯგუფებში	ქვეჯგუფებში	ADV
gs-2738	243	60	(	(	PUNCT
gs-2738	243	61	p>0.05	p>0.05	PROPN
gs-2738	243	62	)	)	PUNCT
gs-2738	243	63	.	.	PUNCT
gs-2738	244	1	ასევე	ასევე	PROPN
gs-2738	244	2	,	,	PUNCT
gs-2738	244	3	მხოლოდ	მხოლოდ	NOUN
gs-2738	244	4	პაციენტებში	პაციენტებში	NOUN
gs-2738	244	5	,	,	PUNCT
gs-2738	244	6	რომლებიც	რომლებიც	ADJ
gs-2738	244	7	იტარებდნენ	იტარებდნენ	PROPN
gs-2738	244	8	მკურნალობას	მკურნალობას	PROPN
gs-2738	244	9	ვალპროატებით	ვალპროატებით	PROPN
gs-2738	244	10	,	,	PUNCT
gs-2738	244	11	pge2	pge2	NOUN
gs-2738	244	12	იყო	იყო	ADJ
gs-2738	244	13	შემცირებული	შემცირებული	PROPN
gs-2738	244	14	,	,	PUNCT
gs-2738	244	15	საშუალო	საშუალო	ADJ
gs-2738	244	16	iqr	iqr	PROPN
gs-2738	244	17	490	490	NUM
gs-2738	244	18	pg	pg	NOUN
gs-2738	244	19	/	/	SYM
gs-2738	244	20	ml	ml	NOUN
gs-2738	244	21	.	.	NOUN
gs-2738	244	22	დასკვნები	დასკვნები	NOUN
gs-2738	244	23	:	:	PUNCT
gs-2738	244	24	ჩვენი	ჩვენი	NOUN
gs-2738	244	25	შედეგები	შედეგები	PROPN
gs-2738	244	26	ემთხვევა	ემთხვევა	PROPN
gs-2738	244	27	პრეკლინიკურ	პრეკლინიკურ	NOUN
gs-2738	245	1	მოდელებში	მოდელებში	PROPN
gs-2738	245	2	წარმოჩენილ	წარმოჩენილ	PROPN
gs-2738	245	3	დასკვნებს	დასკვნებს	PROPN
gs-2738	245	4	,	,	PUNCT
gs-2738	245	5	რომ	რომ	PROPN
gs-2738	245	6	ეპილეფსიის	ეპილეფსიის	PROPN
gs-2738	245	7	პერსონალიზებულ	პერსონალიზებულ	PROPN
gs-2738	245	8	მედიცინაში	მედიცინაში	PROPN
gs-2738	245	9	ციტოკინები	ციტოკინები	PROPN
gs-2738	245	10	შესაძლოა	შესაძლოა	VERB
gs-2738	245	11	განიხილებოდეს	განიხილებოდეს	PRON
gs-2738	245	12	როგორც	როგორც	PROPN
gs-2738	245	13	პოტენციური	პოტენციური	PROPN
gs-2738	245	14	სამიზნე	სამიზნე	PROPN
gs-2738	245	15	,	,	PUNCT
gs-2738	245	16	მოლეკულურ	მოლეკულურ	PROPN
gs-2738	245	17	საფუძველზე	საფუძველზე	PROPN
gs-2738	245	18	ფარმაკორეზისტენტულობის	ფარმაკორეზისტენტულობის	ADV
gs-2738	245	19	დასაძლევად	დასაძლევად	NOUN
gs-2738	245	20	,	,	PUNCT
gs-2738	245	21	რაც	რაც	NOUN
gs-2738	245	22	წარმოადგენს	წარმოადგენს	PROPN
gs-2738	245	23	მთავარ	მთავარ	X
gs-2738	245	24	გამოწვევას	გამოწვევას	X
gs-2738	245	25	ამჟამად	ამჟამად	PROPN
gs-2738	245	26	ეპილეფსიის	ეპილეფსიის	PROPN
gs-2738	245	27	მართვასა	მართვასა	PROPN
gs-2738	245	28	და	და	PROPN
gs-2738	245	29	მკურნალობის	მკურნალობის	NOUN
gs-2738	245	30	გამოსავლის	გამოსავლის	NOUN
gs-2738	245	31	პრედიქციაში.	პრედიქციაში.	VERB