id	sid	tid	token	lemma	pos
gs-3446	1	1	microsoft	microsoft	PROPN
gs-3446	1	2	word	word	NOUN
gs-3446	1	3	fullpdf07012025	fullpdf07012025	PROPN
gs-3446	1	4	georgian	georgian	PROPN
gs-3446	1	5	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3446	1	6	მეცნიერები	მეცნიერები	NOUN
gs-3446	1	7	ტ.	ტ.	VERB
gs-3446	1	8	7	7	NUM
gs-3446	1	9	n	n	PRON
gs-3446	1	10	1	1	NUM
gs-3446	1	11	,	,	PUNCT
gs-3446	1	12	2025	2025	NUM
gs-3446	1	13	271	271	NUM
gs-3446	1	14	georgian	georgian	PROPN
gs-3446	1	15	scientists	scientist	NOUN
gs-3446	1	16	ქართველი	ქართველი	ADJ
gs-3446	1	17	მეცნიერები	მეცნიერები	PROPN
gs-3446	1	18	vol	vol	NOUN
gs-3446	1	19	.	.	PUNCT
gs-3446	1	20	7	7	NUM
gs-3446	1	21	issue	issue	NOUN
gs-3446	1	22	1	1	NUM
gs-3446	1	23	,	,	PUNCT
gs-3446	1	24	2025	2025	NUM
gs-3446	1	25	https://doi.org/10.52340/gs.2025.07.01.26	https://doi.org/10.52340/gs.2025.07.01.26	VERB
gs-3446	1	26	stem	stem	NOUN
gs-3446	1	27	cell	cell	NOUN
gs-3446	1	28	systems	system	NOUN
gs-3446	1	29	and	and	CCONJ
gs-3446	1	30	regeneration	regeneration	NOUN
gs-3446	1	31	david	david	PROPN
gs-3446	1	32	aphkhazava1	aphkhazava1	PROPN
gs-3446	1	33	,	,	PUNCT
gs-3446	1	34	nodar	nodar	PROPN
gs-3446	1	35	sulashvili2	sulashvili2	PROPN
gs-3446	1	36	,	,	PUNCT
gs-3446	1	37	jaba	jaba	PROPN
gs-3446	1	38	tkemaladze3	tkemaladze3	PROPN
gs-3446	2	1	1phd	1phd	PROPN
gs-3446	2	2	,	,	PUNCT
gs-3446	2	3	doctor	doctor	NOUN
gs-3446	2	4	of	of	ADP
gs-3446	2	5	biological	biological	ADJ
gs-3446	2	6	sciences	science	NOUN
gs-3446	2	7	,	,	PUNCT
gs-3446	2	8	professor	professor	NOUN
gs-3446	2	9	of	of	ADP
gs-3446	2	10	biochemistry	biochemistry	NOUN
gs-3446	2	11	of	of	ADP
gs-3446	2	12	international	international	ADJ
gs-3446	2	13	school	school	NOUN
gs-3446	2	14	of	of	ADP
gs-3446	2	15	medicine	medicine	NOUN
gs-3446	2	16	at	at	ADP
gs-3446	2	17	alte	alte	PROPN
gs-3446	2	18	university	university	PROPN
gs-3446	2	19	,	,	PUNCT
gs-3446	2	20	tbilisi	tbilisi	PROPN
gs-3446	2	21	,	,	PUNCT
gs-3446	2	22	georgia	georgia	PROPN
gs-3446	2	23	,	,	PUNCT
gs-3446	2	24	https://orcid.org/0000-0001-6216-6477	https://orcid.org/0000-0001-6216-6477	NOUN
gs-3446	2	25	;	;	PUNCT
gs-3446	2	26	d.apkhazava@alte.edu.ge	d.apkhazava@alte.edu.ge	NOUN
gs-3446	2	27	;	;	PUNCT
gs-3446	2	28	2md	2md	NUM
gs-3446	2	29	,	,	PUNCT
gs-3446	2	30	phd	phd	NOUN
gs-3446	2	31	,	,	PUNCT
gs-3446	2	32	doctor	doctor	NOUN
gs-3446	2	33	of	of	ADP
gs-3446	2	34	pharmaceutical	pharmaceutical	ADJ
gs-3446	2	35	and	and	CCONJ
gs-3446	2	36	pharmacological	pharmacological	ADJ
gs-3446	2	37	sciences	science	NOUN
gs-3446	2	38	,	,	PUNCT
gs-3446	2	39	professor	professor	NOUN
gs-3446	2	40	of	of	ADP
gs-3446	2	41	pharmacology	pharmacology	NOUN
gs-3446	2	42	of	of	ADP
gs-3446	2	43	international	international	ADJ
gs-3446	2	44	school	school	NOUN
gs-3446	2	45	of	of	ADP
gs-3446	2	46	medicine	medicine	NOUN
gs-3446	2	47	at	at	ADP
gs-3446	2	48	alte	alte	PROPN
gs-3446	2	49	university	university	PROPN
gs-3446	2	50	,	,	PUNCT
gs-3446	2	51	tbilisi	tbilisi	PROPN
gs-3446	2	52	,	,	PUNCT
gs-3446	2	53	georgia	georgia	PROPN
gs-3446	2	54	,	,	PUNCT
gs-3446	2	55	https://orcid.org/0000-0002-9005-8577	https://orcid.org/0000-0002-9005-8577	PROPN
gs-3446	2	56	;	;	PUNCT
gs-3446	2	57	n.sulashvili@ug.edu.ge	n.sulashvili@ug.edu.ge	PROPN
gs-3446	2	58	;	;	PUNCT
gs-3446	2	59	3research	3research	NUM
gs-3446	2	60	director	director	NOUN
gs-3446	2	61	,	,	PUNCT
gs-3446	2	62	longevity	longevity	NOUN
gs-3446	2	63	clinic	clinic	NOUN
gs-3446	2	64	,	,	PUNCT
gs-3446	2	65	46	46	NUM
gs-3446	2	66	shota	shota	PROPN
gs-3446	2	67	rustaveli	rustaveli	ADJ
gs-3446	2	68	street	street	PROPN
gs-3446	2	69	,	,	PUNCT
gs-3446	2	70	3001	3001	NUM
gs-3446	2	71	,	,	PUNCT
gs-3446	2	72	abastumani	abastumani	ADJ
gs-3446	2	73	,	,	PUNCT
gs-3446	2	74	georgia	georgia	PROPN
gs-3446	2	75	,	,	PUNCT
gs-3446	2	76	https://orcid.org/0000-0001-8651-7243	https://orcid.org/0000-0001-8651-7243	PROPN
gs-3446	2	77	;	;	PUNCT
gs-3446	2	78	jtkemaladze@longevity.ge	jtkemaladze@longevity.ge	X
gs-3446	2	79	abstract	abstract	ADJ
gs-3446	2	80	stem	stem	NOUN
gs-3446	2	81	cell	cell	NOUN
gs-3446	2	82	systems	system	NOUN
gs-3446	2	83	are	be	AUX
gs-3446	2	84	pivotal	pivotal	ADJ
gs-3446	2	85	in	in	ADP
gs-3446	2	86	biological	biological	ADJ
gs-3446	2	87	development	development	NOUN
gs-3446	2	88	,	,	PUNCT
gs-3446	2	89	tissue	tissue	NOUN
gs-3446	2	90	maintenance	maintenance	NOUN
gs-3446	2	91	,	,	PUNCT
gs-3446	2	92	and	and	CCONJ
gs-3446	2	93	regenerative	regenerative	ADJ
gs-3446	2	94	medicine	medicine	NOUN
gs-3446	2	95	due	due	ADP
gs-3446	2	96	to	to	ADP
gs-3446	2	97	their	their	PRON
gs-3446	2	98	dual	dual	ADJ
gs-3446	2	99	capacity	capacity	NOUN
gs-3446	2	100	for	for	ADP
gs-3446	2	101	self	self	NOUN
gs-3446	2	102	-	-	PUNCT
gs-3446	2	103	renewal	renewal	NOUN
gs-3446	2	104	and	and	CCONJ
gs-3446	2	105	differentiation	differentiation	NOUN
gs-3446	2	106	.	.	PUNCT
gs-3446	3	1	this	this	DET
gs-3446	3	2	review	review	NOUN
gs-3446	3	3	explores	explore	VERB
gs-3446	3	4	the	the	DET
gs-3446	3	5	heterogeneity	heterogeneity	NOUN
gs-3446	3	6	and	and	CCONJ
gs-3446	3	7	regulatory	regulatory	ADJ
gs-3446	3	8	mechanisms	mechanism	NOUN
gs-3446	3	9	governing	govern	VERB
gs-3446	3	10	stem	stem	NOUN
gs-3446	3	11	cells	cell	NOUN
gs-3446	3	12	across	across	ADP
gs-3446	3	13	potency	potency	NOUN
gs-3446	3	14	states	state	NOUN
gs-3446	3	15	—	—	PUNCT
gs-3446	3	16	pluripotent	pluripotent	ADJ
gs-3446	3	17	,	,	PUNCT
gs-3446	3	18	multipotent	multipotent	NOUN
gs-3446	3	19	,	,	PUNCT
gs-3446	3	20	and	and	CCONJ
gs-3446	3	21	unipotent	unipotent	ADJ
gs-3446	3	22	—	—	PUNCT
gs-3446	3	23	emphasizing	emphasize	VERB
gs-3446	3	24	dynamic	dynamic	ADJ
gs-3446	3	25	transcriptional	transcriptional	ADJ
gs-3446	3	26	circuits	circuit	NOUN
gs-3446	3	27	involving	involve	VERB
gs-3446	3	28	core	core	NOUN
gs-3446	3	29	factors	factor	NOUN
gs-3446	3	30	(	(	PUNCT
gs-3446	3	31	oct4	oct4	PROPN
gs-3446	3	32	,	,	PUNCT
gs-3446	3	33	sox2	sox2	NOUN
gs-3446	3	34	,	,	PUNCT
gs-3446	3	35	nanog	nanog	PROPN
gs-3446	3	36	)	)	PUNCT
gs-3446	3	37	and	and	CCONJ
gs-3446	3	38	signaling	signal	VERB
gs-3446	3	39	pathways	pathway	NOUN
gs-3446	3	40	(	(	PUNCT
gs-3446	3	41	wnt	wnt	PROPN
gs-3446	3	42	/	/	SYM
gs-3446	3	43	β	β	NOUN
gs-3446	3	44	-	-	ADJ
gs-3446	3	45	catenin	catenin	ADJ
gs-3446	3	46	,	,	PUNCT
gs-3446	3	47	notch	notch	NOUN
gs-3446	3	48	,	,	PUNCT
gs-3446	3	49	hedgehog	hedgehog	NOUN
gs-3446	3	50	)	)	PUNCT
gs-3446	3	51	.	.	PUNCT
gs-3446	4	1	stem	stem	NOUN
gs-3446	4	2	cell	cell	NOUN
gs-3446	4	3	homeostasis	homeostasis	NOUN
gs-3446	4	4	,	,	PUNCT
gs-3446	4	5	critical	critical	ADJ
gs-3446	4	6	for	for	ADP
gs-3446	4	7	tissue	tissue	NOUN
gs-3446	4	8	integrity	integrity	NOUN
gs-3446	4	9	,	,	PUNCT
gs-3446	4	10	is	be	AUX
gs-3446	4	11	maintained	maintain	VERB
gs-3446	4	12	through	through	ADP
gs-3446	4	13	intrinsic	intrinsic	ADJ
gs-3446	4	14	(	(	PUNCT
gs-3446	4	15	epigenetic	epigenetic	ADJ
gs-3446	4	16	,	,	PUNCT
gs-3446	4	17	metabolic	metabolic	NOUN
gs-3446	4	18	)	)	PUNCT
gs-3446	4	19	and	and	CCONJ
gs-3446	4	20	extrinsic	extrinsic	ADJ
gs-3446	4	21	(	(	PUNCT
gs-3446	4	22	nichederived	nichederived	ADJ
gs-3446	4	23	)	)	PUNCT
gs-3446	4	24	cues	cue	NOUN
gs-3446	4	25	,	,	PUNCT
gs-3446	4	26	with	with	ADP
gs-3446	4	27	disruptions	disruption	NOUN
gs-3446	4	28	linked	link	VERB
gs-3446	4	29	to	to	ADP
gs-3446	4	30	aging	age	VERB
gs-3446	4	31	,	,	PUNCT
gs-3446	4	32	degenerative	degenerative	ADJ
gs-3446	4	33	diseases	disease	NOUN
gs-3446	4	34	,	,	PUNCT
gs-3446	4	35	and	and	CCONJ
gs-3446	4	36	cancer	cancer	NOUN
gs-3446	4	37	.	.	PUNCT
gs-3446	5	1	advances	advance	NOUN
gs-3446	5	2	in	in	ADP
gs-3446	5	3	induced	induced	ADJ
gs-3446	5	4	pluripotent	pluripotent	ADJ
gs-3446	5	5	stem	stem	NOUN
gs-3446	5	6	cells	cell	NOUN
gs-3446	5	7	(	(	PUNCT
gs-3446	5	8	ipscs	ipscs	NOUN
gs-3446	5	9	)	)	PUNCT
gs-3446	5	10	and	and	CCONJ
gs-3446	5	11	genome	genome	NOUN
gs-3446	5	12	editing	editing	NOUN
gs-3446	5	13	(	(	PUNCT
gs-3446	5	14	crispr	crispr	NOUN
gs-3446	5	15	-	-	PUNCT
gs-3446	5	16	cas9	cas9	NOUN
gs-3446	5	17	)	)	PUNCT
gs-3446	5	18	offer	offer	VERB
gs-3446	5	19	transformative	transformative	ADJ
gs-3446	5	20	potential	potential	NOUN
gs-3446	5	21	for	for	ADP
gs-3446	5	22	personalized	personalized	ADJ
gs-3446	5	23	therapies	therapy	NOUN
gs-3446	5	24	,	,	PUNCT
gs-3446	5	25	yet	yet	ADV
gs-3446	5	26	challenges	challenge	NOUN
gs-3446	5	27	such	such	ADJ
gs-3446	5	28	as	as	ADP
gs-3446	5	29	tumorigenicity	tumorigenicity	NOUN
gs-3446	5	30	,	,	PUNCT
gs-3446	5	31	immune	immune	ADJ
gs-3446	5	32	rejection	rejection	NOUN
gs-3446	5	33	,	,	PUNCT
gs-3446	5	34	and	and	CCONJ
gs-3446	5	35	ethical	ethical	ADJ
gs-3446	5	36	concerns	concern	NOUN
gs-3446	5	37	persist	persist	VERB
gs-3446	5	38	.	.	PUNCT
gs-3446	6	1	the	the	DET
gs-3446	6	2	role	role	NOUN
gs-3446	6	3	of	of	ADP
gs-3446	6	4	stem	stem	NOUN
gs-3446	6	5	cell	cell	NOUN
gs-3446	6	6	niches	niche	NOUN
gs-3446	6	7	in	in	ADP
gs-3446	6	8	modulating	modulate	VERB
gs-3446	6	9	quiescence	quiescence	NOUN
gs-3446	6	10	,	,	PUNCT
gs-3446	6	11	proliferation	proliferation	NOUN
gs-3446	6	12	,	,	PUNCT
gs-3446	6	13	and	and	CCONJ
gs-3446	6	14	differentiation	differentiation	NOUN
gs-3446	6	15	is	be	AUX
gs-3446	6	16	highlighted	highlight	VERB
gs-3446	6	17	,	,	PUNCT
gs-3446	6	18	alongside	alongside	ADP
gs-3446	6	19	applications	application	NOUN
gs-3446	6	20	in	in	ADP
gs-3446	6	21	tissue	tissue	NOUN
gs-3446	6	22	engineering	engineering	NOUN
gs-3446	6	23	,	,	PUNCT
gs-3446	6	24	organoid	organoid	NOUN
gs-3446	6	25	development	development	NOUN
gs-3446	6	26	,	,	PUNCT
gs-3446	6	27	and	and	CCONJ
gs-3446	6	28	disease	disease	NOUN
gs-3446	6	29	modeling	modeling	NOUN
gs-3446	6	30	.	.	PUNCT
gs-3446	7	1	aging	age	VERB
gs-3446	7	2	-	-	PUNCT
gs-3446	7	3	associated	associate	VERB
gs-3446	7	4	decline	decline	NOUN
gs-3446	7	5	in	in	ADP
gs-3446	7	6	stem	stem	NOUN
gs-3446	7	7	cell	cell	NOUN
gs-3446	7	8	function	function	NOUN
gs-3446	7	9	,	,	PUNCT
gs-3446	7	10	driven	drive	VERB
gs-3446	7	11	by	by	ADP
gs-3446	7	12	oxidative	oxidative	ADJ
gs-3446	7	13	stress	stress	NOUN
gs-3446	7	14	,	,	PUNCT
gs-3446	7	15	dna	dna	NOUN
gs-3446	7	16	damage	damage	NOUN
gs-3446	7	17	,	,	PUNCT
gs-3446	7	18	and	and	CCONJ
gs-3446	7	19	epigenetic	epigenetic	ADJ
gs-3446	7	20	alterations	alteration	NOUN
gs-3446	7	21	,	,	PUNCT
gs-3446	7	22	underscores	underscore	VERB
gs-3446	7	23	the	the	DET
gs-3446	7	24	need	need	NOUN
gs-3446	7	25	for	for	ADP
gs-3446	7	26	rejuvenation	rejuvenation	NOUN
gs-3446	7	27	strategies	strategy	NOUN
gs-3446	7	28	.	.	PUNCT
gs-3446	8	1	furthermore	furthermore	ADV
gs-3446	8	2	,	,	PUNCT
gs-3446	8	3	dysregulated	dysregulated	ADJ
gs-3446	8	4	transcriptional	transcriptional	ADJ
gs-3446	8	5	networks	network	NOUN
gs-3446	8	6	in	in	ADP
gs-3446	8	7	cancer	cancer	NOUN
gs-3446	8	8	stem	stem	NOUN
gs-3446	8	9	cells	cell	NOUN
gs-3446	8	10	(	(	PUNCT
gs-3446	8	11	cscs	cscs	PROPN
gs-3446	8	12	)	)	PUNCT
gs-3446	8	13	present	present	ADJ
gs-3446	8	14	therapeutic	therapeutic	ADJ
gs-3446	8	15	targets	target	NOUN
gs-3446	8	16	for	for	ADP
gs-3446	8	17	precision	precision	NOUN
gs-3446	8	18	oncology	oncology	NOUN
gs-3446	8	19	.	.	PUNCT
gs-3446	9	1	future	future	ADJ
gs-3446	9	2	directions	direction	NOUN
gs-3446	9	3	emphasize	emphasize	VERB
gs-3446	9	4	single	single	ADJ
gs-3446	9	5	-	-	PUNCT
gs-3446	9	6	cell	cell	NOUN
gs-3446	9	7	multiomics	multiomics	NOUN
gs-3446	9	8	,	,	PUNCT
gs-3446	9	9	synthetic	synthetic	ADJ
gs-3446	9	10	biology	biology	NOUN
gs-3446	9	11	,	,	PUNCT
gs-3446	9	12	and	and	CCONJ
gs-3446	9	13	bioengineered	bioengineere	VERB
gs-3446	9	14	niches	niche	NOUN
gs-3446	9	15	to	to	PART
gs-3446	9	16	refine	refine	VERB
gs-3446	9	17	differentiation	differentiation	NOUN
gs-3446	9	18	protocols	protocol	NOUN
gs-3446	9	19	and	and	CCONJ
gs-3446	9	20	enhance	enhance	VERB
gs-3446	9	21	clinical	clinical	ADJ
gs-3446	9	22	translation	translation	NOUN
gs-3446	9	23	.	.	PUNCT
gs-3446	10	1	by	by	ADP
gs-3446	10	2	integrating	integrate	VERB
gs-3446	10	3	molecular	molecular	ADJ
gs-3446	10	4	insights	insight	NOUN
gs-3446	10	5	with	with	ADP
gs-3446	10	6	technological	technological	ADJ
gs-3446	10	7	innovations	innovation	NOUN
gs-3446	10	8	,	,	PUNCT
gs-3446	10	9	stem	stem	NOUN
gs-3446	10	10	cell	cell	NOUN
gs-3446	10	11	research	research	NOUN
gs-3446	10	12	promises	promise	NOUN
gs-3446	10	13	to	to	PART
gs-3446	10	14	bridge	bridge	VERB
gs-3446	10	15	gaps	gap	NOUN
gs-3446	10	16	in	in	ADP
gs-3446	10	17	regenerative	regenerative	ADJ
gs-3446	10	18	medicine	medicine	NOUN
gs-3446	10	19	,	,	PUNCT
gs-3446	10	20	offering	offer	VERB
gs-3446	10	21	novel	novel	ADJ
gs-3446	10	22	solutions	solution	NOUN
gs-3446	10	23	for	for	ADP
gs-3446	10	24	degenerative	degenerative	ADJ
gs-3446	10	25	disorders	disorder	NOUN
gs-3446	10	26	,	,	PUNCT
gs-3446	10	27	injury	injury	NOUN
gs-3446	10	28	repair	repair	NOUN
gs-3446	10	29	,	,	PUNCT
gs-3446	10	30	and	and	CCONJ
gs-3446	10	31	personalized	personalized	ADJ
gs-3446	10	32	healthcare	healthcare	NOUN
gs-3446	10	33	.	.	PUNCT
gs-3446	11	1	keywords	keyword	NOUN
gs-3446	11	2	:	:	PUNCT
gs-3446	11	3	regeneration	regeneration	NOUN
gs-3446	11	4	,	,	PUNCT
gs-3446	11	5	tissue	tissue	NOUN
gs-3446	11	6	self	self	NOUN
gs-3446	11	7	-	-	PUNCT
gs-3446	11	8	renewal	renewal	NOUN
gs-3446	11	9	,	,	PUNCT
gs-3446	11	10	stem	stem	NOUN
gs-3446	11	11	cells	cell	NOUN
gs-3446	11	12	,	,	PUNCT
gs-3446	11	13	asymmetric	asymmetric	ADJ
gs-3446	11	14	division	division	NOUN
gs-3446	11	15	,	,	PUNCT
gs-3446	11	16	signaling	signal	VERB
gs-3446	11	17	pathways	pathway	NOUN
gs-3446	11	18	,	,	PUNCT
gs-3446	11	19	aging	aging	NOUN
gs-3446	11	20	,	,	PUNCT
gs-3446	11	21	cell	cell	NOUN
gs-3446	11	22	division	division	NOUN
gs-3446	11	23	temp	temp	NOUN
gs-3446	11	24	,	,	PUNCT
gs-3446	11	25	crispr	crispr	NOUN
gs-3446	11	26	-	-	PUNCT
gs-3446	11	27	cas9	cas9	NOUN
gs-3446	11	28	,	,	PUNCT
gs-3446	11	29	ipscs	ipscs	NOUN
gs-3446	11	30	georgian	georgian	ADJ
gs-3446	11	31	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	11	32	მეცნიერები	მეცნიერები	NOUN
gs-3446	11	33	ტ.	ტ.	VERB
gs-3446	11	34	7	7	NUM
gs-3446	11	35	n	n	PRON
gs-3446	11	36	1	1	NUM
gs-3446	11	37	,	,	PUNCT
gs-3446	11	38	2025	2025	NUM
gs-3446	11	39	272	272	NUM
gs-3446	11	40	introduction	introduction	NOUN
gs-3446	11	41	stem	stem	NOUN
gs-3446	11	42	cell	cell	NOUN
gs-3446	11	43	systems	system	NOUN
gs-3446	11	44	represent	represent	VERB
gs-3446	11	45	a	a	DET
gs-3446	11	46	cornerstone	cornerstone	NOUN
gs-3446	11	47	of	of	ADP
gs-3446	11	48	modern	modern	ADJ
gs-3446	11	49	biological	biological	ADJ
gs-3446	11	50	and	and	CCONJ
gs-3446	11	51	medical	medical	ADJ
gs-3446	11	52	research	research	NOUN
gs-3446	11	53	due	due	ADP
gs-3446	11	54	to	to	ADP
gs-3446	11	55	their	their	PRON
gs-3446	11	56	unique	unique	ADJ
gs-3446	11	57	capacity	capacity	NOUN
gs-3446	11	58	for	for	ADP
gs-3446	11	59	self	self	NOUN
gs-3446	11	60	-	-	PUNCT
gs-3446	11	61	renewal	renewal	NOUN
gs-3446	11	62	and	and	CCONJ
gs-3446	11	63	differentiation	differentiation	NOUN
gs-3446	11	64	.	.	PUNCT
gs-3446	12	1	these	these	DET
gs-3446	12	2	properties	property	NOUN
gs-3446	12	3	allow	allow	VERB
gs-3446	12	4	stem	stem	NOUN
gs-3446	12	5	cells	cell	NOUN
gs-3446	12	6	to	to	PART
gs-3446	12	7	generate	generate	VERB
gs-3446	12	8	diverse	diverse	ADJ
gs-3446	12	9	cell	cell	NOUN
gs-3446	12	10	types	type	NOUN
gs-3446	12	11	necessary	necessary	ADJ
gs-3446	12	12	for	for	ADP
gs-3446	12	13	growth	growth	NOUN
gs-3446	12	14	,	,	PUNCT
gs-3446	12	15	development	development	NOUN
gs-3446	12	16	,	,	PUNCT
gs-3446	12	17	and	and	CCONJ
gs-3446	12	18	tissue	tissue	NOUN
gs-3446	12	19	maintenance	maintenance	NOUN
gs-3446	12	20	.	.	PUNCT
gs-3446	13	1	the	the	DET
gs-3446	13	2	study	study	NOUN
gs-3446	13	3	of	of	ADP
gs-3446	13	4	stem	stem	NOUN
gs-3446	13	5	cell	cell	NOUN
gs-3446	13	6	systems	system	NOUN
gs-3446	13	7	has	have	AUX
gs-3446	13	8	provided	provide	VERB
gs-3446	13	9	significant	significant	ADJ
gs-3446	13	10	insights	insight	NOUN
gs-3446	13	11	into	into	ADP
gs-3446	13	12	the	the	DET
gs-3446	13	13	mechanisms	mechanism	NOUN
gs-3446	13	14	of	of	ADP
gs-3446	13	15	regeneration	regeneration	NOUN
gs-3446	13	16	,	,	PUNCT
gs-3446	13	17	repair	repair	NOUN
gs-3446	13	18	,	,	PUNCT
gs-3446	13	19	and	and	CCONJ
gs-3446	13	20	disease	disease	NOUN
gs-3446	13	21	pathology	pathology	NOUN
gs-3446	13	22	,	,	PUNCT
gs-3446	13	23	thereby	thereby	ADV
gs-3446	13	24	paving	pave	VERB
gs-3446	13	25	the	the	DET
gs-3446	13	26	way	way	NOUN
gs-3446	13	27	for	for	ADP
gs-3446	13	28	novel	novel	ADJ
gs-3446	13	29	therapeutic	therapeutic	ADJ
gs-3446	13	30	strategies	strategy	NOUN
gs-3446	13	31	.	.	PUNCT
gs-3446	14	1	the	the	DET
gs-3446	14	2	regenerative	regenerative	ADJ
gs-3446	14	3	potential	potential	NOUN
gs-3446	14	4	of	of	ADP
gs-3446	14	5	stem	stem	NOUN
gs-3446	14	6	cells	cell	NOUN
gs-3446	14	7	is	be	AUX
gs-3446	14	8	a	a	DET
gs-3446	14	9	subject	subject	NOUN
gs-3446	14	10	of	of	ADP
gs-3446	14	11	immense	immense	ADJ
gs-3446	14	12	scientific	scientific	ADJ
gs-3446	14	13	interest	interest	NOUN
gs-3446	14	14	,	,	PUNCT
gs-3446	14	15	as	as	SCONJ
gs-3446	14	16	it	it	PRON
gs-3446	14	17	holds	hold	VERB
gs-3446	14	18	the	the	DET
gs-3446	14	19	key	key	NOUN
gs-3446	14	20	to	to	ADP
gs-3446	14	21	understanding	understanding	NOUN
gs-3446	14	22	and	and	CCONJ
gs-3446	14	23	potentially	potentially	ADV
gs-3446	14	24	treating	treat	VERB
gs-3446	14	25	degenerative	degenerative	ADJ
gs-3446	14	26	diseases	disease	NOUN
gs-3446	14	27	,	,	PUNCT
gs-3446	14	28	injuries	injury	NOUN
gs-3446	14	29	,	,	PUNCT
gs-3446	14	30	and	and	CCONJ
gs-3446	14	31	aging	age	VERB
gs-3446	14	32	-	-	PUNCT
gs-3446	14	33	related	relate	VERB
gs-3446	14	34	conditions	condition	NOUN
gs-3446	14	35	.	.	PUNCT
gs-3446	15	1	by	by	ADP
gs-3446	15	2	examining	examine	VERB
gs-3446	15	3	the	the	DET
gs-3446	15	4	characteristics	characteristic	NOUN
gs-3446	15	5	of	of	ADP
gs-3446	15	6	stem	stem	NOUN
gs-3446	15	7	cell	cell	NOUN
gs-3446	15	8	systems	system	NOUN
gs-3446	15	9	and	and	CCONJ
gs-3446	15	10	their	their	PRON
gs-3446	15	11	regenerative	regenerative	ADJ
gs-3446	15	12	capabilities	capability	NOUN
gs-3446	15	13	,	,	PUNCT
gs-3446	15	14	researchers	researcher	NOUN
gs-3446	15	15	aim	aim	VERB
gs-3446	15	16	to	to	PART
gs-3446	15	17	harness	harness	VERB
gs-3446	15	18	their	their	PRON
gs-3446	15	19	power	power	NOUN
gs-3446	15	20	to	to	PART
gs-3446	15	21	develop	develop	VERB
gs-3446	15	22	advanced	advanced	ADJ
gs-3446	15	23	medical	medical	ADJ
gs-3446	15	24	interventions	intervention	NOUN
gs-3446	15	25	,	,	PUNCT
gs-3446	15	26	including	include	VERB
gs-3446	15	27	tissue	tissue	NOUN
gs-3446	15	28	engineering	engineering	NOUN
gs-3446	15	29	and	and	CCONJ
gs-3446	15	30	cell	cell	NOUN
gs-3446	15	31	-	-	PUNCT
gs-3446	15	32	based	base	VERB
gs-3446	15	33	therapies	therapy	NOUN
gs-3446	15	34	.	.	PUNCT
gs-3446	16	1	stem	stem	NOUN
gs-3446	16	2	cells	cell	NOUN
gs-3446	16	3	are	be	AUX
gs-3446	16	4	broadly	broadly	ADV
gs-3446	16	5	classified	classify	VERB
gs-3446	16	6	into	into	ADP
gs-3446	16	7	embryonic	embryonic	ADJ
gs-3446	16	8	stem	stem	NOUN
gs-3446	16	9	cells	cell	NOUN
gs-3446	16	10	,	,	PUNCT
gs-3446	16	11	adult	adult	NOUN
gs-3446	16	12	stem	stem	NOUN
gs-3446	16	13	cells	cell	NOUN
gs-3446	16	14	,	,	PUNCT
gs-3446	16	15	and	and	CCONJ
gs-3446	16	16	induced	induce	VERB
gs-3446	16	17	pluripotent	pluripotent	ADJ
gs-3446	16	18	stem	stem	NOUN
gs-3446	16	19	cells	cell	NOUN
gs-3446	16	20	(	(	PUNCT
gs-3446	16	21	ipscs	ipscs	NOUN
gs-3446	16	22	)	)	PUNCT
gs-3446	16	23	,	,	PUNCT
gs-3446	16	24	each	each	PRON
gs-3446	16	25	possessing	possess	VERB
gs-3446	16	26	distinct	distinct	ADJ
gs-3446	16	27	features	feature	NOUN
gs-3446	16	28	that	that	PRON
gs-3446	16	29	determine	determine	VERB
gs-3446	16	30	their	their	PRON
gs-3446	16	31	potential	potential	ADJ
gs-3446	16	32	applications	application	NOUN
gs-3446	16	33	.	.	PUNCT
gs-3446	17	1	embryonic	embryonic	ADJ
gs-3446	17	2	stem	stem	NOUN
gs-3446	17	3	cells	cell	NOUN
gs-3446	17	4	,	,	PUNCT
gs-3446	17	5	derived	derive	VERB
gs-3446	17	6	from	from	ADP
gs-3446	17	7	the	the	DET
gs-3446	17	8	inner	inner	ADJ
gs-3446	17	9	cell	cell	NOUN
gs-3446	17	10	mass	mass	NOUN
gs-3446	17	11	of	of	ADP
gs-3446	17	12	a	a	DET
gs-3446	17	13	blastocyst	blastocyst	NOUN
gs-3446	17	14	,	,	PUNCT
gs-3446	17	15	exhibit	exhibit	NOUN
gs-3446	17	16	pluripotency	pluripotency	NOUN
gs-3446	17	17	,	,	PUNCT
gs-3446	17	18	meaning	mean	VERB
gs-3446	17	19	they	they	PRON
gs-3446	17	20	can	can	AUX
gs-3446	17	21	differentiate	differentiate	VERB
gs-3446	17	22	into	into	ADP
gs-3446	17	23	any	any	DET
gs-3446	17	24	cell	cell	NOUN
gs-3446	17	25	type	type	NOUN
gs-3446	17	26	in	in	ADP
gs-3446	17	27	the	the	DET
gs-3446	17	28	body	body	NOUN
gs-3446	17	29	.	.	PUNCT
gs-3446	18	1	this	this	DET
gs-3446	18	2	characteristic	characteristic	NOUN
gs-3446	18	3	makes	make	VERB
gs-3446	18	4	them	they	PRON
gs-3446	18	5	a	a	DET
gs-3446	18	6	valuable	valuable	ADJ
gs-3446	18	7	resource	resource	NOUN
gs-3446	18	8	for	for	ADP
gs-3446	18	9	developmental	developmental	ADJ
gs-3446	18	10	studies	study	NOUN
gs-3446	18	11	and	and	CCONJ
gs-3446	18	12	regenerative	regenerative	ADJ
gs-3446	18	13	medicine	medicine	NOUN
gs-3446	18	14	.	.	PUNCT
gs-3446	19	1	however	however	ADV
gs-3446	19	2	,	,	PUNCT
gs-3446	19	3	ethical	ethical	ADJ
gs-3446	19	4	concerns	concern	NOUN
gs-3446	19	5	and	and	CCONJ
gs-3446	19	6	potential	potential	ADJ
gs-3446	19	7	immunogenicity	immunogenicity	NOUN
gs-3446	19	8	have	have	AUX
gs-3446	19	9	led	lead	VERB
gs-3446	19	10	to	to	ADP
gs-3446	19	11	the	the	DET
gs-3446	19	12	exploration	exploration	NOUN
gs-3446	19	13	of	of	ADP
gs-3446	19	14	alternative	alternative	ADJ
gs-3446	19	15	stem	stem	NOUN
gs-3446	19	16	cell	cell	NOUN
gs-3446	19	17	sources	source	NOUN
gs-3446	19	18	.	.	PUNCT
gs-3446	20	1	adult	adult	NOUN
gs-3446	20	2	stem	stem	NOUN
gs-3446	20	3	cells	cell	NOUN
gs-3446	20	4	,	,	PUNCT
gs-3446	20	5	found	find	VERB
gs-3446	20	6	in	in	ADP
gs-3446	20	7	specific	specific	ADJ
gs-3446	20	8	tissues	tissue	NOUN
gs-3446	20	9	such	such	ADJ
gs-3446	20	10	as	as	ADP
gs-3446	20	11	bone	bone	NOUN
gs-3446	20	12	marrow	marrow	NOUN
gs-3446	20	13	,	,	PUNCT
gs-3446	20	14	skin	skin	NOUN
gs-3446	20	15	,	,	PUNCT
gs-3446	20	16	and	and	CCONJ
gs-3446	20	17	the	the	DET
gs-3446	20	18	brain	brain	NOUN
gs-3446	20	19	,	,	PUNCT
gs-3446	20	20	are	be	AUX
gs-3446	20	21	typically	typically	ADV
gs-3446	20	22	multipotent	multipotent	ADJ
gs-3446	20	23	,	,	PUNCT
gs-3446	20	24	meaning	mean	VERB
gs-3446	20	25	they	they	PRON
gs-3446	20	26	can	can	AUX
gs-3446	20	27	differentiate	differentiate	VERB
gs-3446	20	28	into	into	ADP
gs-3446	20	29	a	a	DET
gs-3446	20	30	limited	limited	ADJ
gs-3446	20	31	range	range	NOUN
gs-3446	20	32	of	of	ADP
gs-3446	20	33	cell	cell	NOUN
gs-3446	20	34	types	type	NOUN
gs-3446	20	35	.	.	PUNCT
gs-3446	21	1	while	while	SCONJ
gs-3446	21	2	their	their	PRON
gs-3446	21	3	regenerative	regenerative	ADJ
gs-3446	21	4	capacity	capacity	NOUN
gs-3446	21	5	is	be	AUX
gs-3446	21	6	more	more	ADV
gs-3446	21	7	restricted	restricted	ADJ
gs-3446	21	8	than	than	ADP
gs-3446	21	9	that	that	PRON
gs-3446	21	10	of	of	ADP
gs-3446	21	11	embryonic	embryonic	ADJ
gs-3446	21	12	stem	stem	NOUN
gs-3446	21	13	cells	cell	NOUN
gs-3446	21	14	,	,	PUNCT
gs-3446	21	15	their	their	PRON
gs-3446	21	16	use	use	NOUN
gs-3446	21	17	is	be	AUX
gs-3446	21	18	often	often	ADV
gs-3446	21	19	preferred	prefer	VERB
gs-3446	21	20	due	due	ADP
gs-3446	21	21	to	to	ADP
gs-3446	21	22	their	their	PRON
gs-3446	21	23	ability	ability	NOUN
gs-3446	21	24	to	to	PART
gs-3446	21	25	be	be	AUX
gs-3446	21	26	derived	derive	VERB
gs-3446	21	27	from	from	ADP
gs-3446	21	28	the	the	DET
gs-3446	21	29	patient	patient	NOUN
gs-3446	21	30	’s	’s	PART
gs-3446	21	31	own	own	ADJ
gs-3446	21	32	body	body	NOUN
gs-3446	21	33	,	,	PUNCT
gs-3446	21	34	thereby	thereby	ADV
gs-3446	21	35	reducing	reduce	VERB
gs-3446	21	36	the	the	DET
gs-3446	21	37	risk	risk	NOUN
gs-3446	21	38	of	of	ADP
gs-3446	21	39	immune	immune	ADJ
gs-3446	21	40	rejection	rejection	NOUN
gs-3446	21	41	.	.	PUNCT
gs-3446	22	1	induced	induce	VERB
gs-3446	22	2	pluripotent	pluripotent	ADJ
gs-3446	22	3	stem	stem	NOUN
gs-3446	22	4	cells	cell	NOUN
gs-3446	22	5	,	,	PUNCT
gs-3446	22	6	reprogrammed	reprogramme	VERB
gs-3446	22	7	from	from	ADP
gs-3446	22	8	adult	adult	NOUN
gs-3446	22	9	somatic	somatic	ADJ
gs-3446	22	10	cells	cell	NOUN
gs-3446	22	11	,	,	PUNCT
gs-3446	22	12	offer	offer	VERB
gs-3446	22	13	an	an	DET
gs-3446	22	14	exciting	exciting	ADJ
gs-3446	22	15	avenue	avenue	NOUN
gs-3446	22	16	for	for	ADP
gs-3446	22	17	patient	patient	NOUN
gs-3446	22	18	-	-	PUNCT
gs-3446	22	19	specific	specific	ADJ
gs-3446	22	20	therapies	therapy	NOUN
gs-3446	22	21	,	,	PUNCT
gs-3446	22	22	as	as	SCONJ
gs-3446	22	23	they	they	PRON
gs-3446	22	24	combine	combine	VERB
gs-3446	22	25	the	the	DET
gs-3446	22	26	advantages	advantage	NOUN
gs-3446	22	27	of	of	ADP
gs-3446	22	28	pluripotency	pluripotency	NOUN
gs-3446	22	29	with	with	ADP
gs-3446	22	30	the	the	DET
gs-3446	22	31	ability	ability	NOUN
gs-3446	22	32	to	to	PART
gs-3446	22	33	generate	generate	VERB
gs-3446	22	34	personalized	personalized	ADJ
gs-3446	22	35	treatments	treatment	NOUN
gs-3446	22	36	(	(	PUNCT
gs-3446	22	37	sulashvili	sulashvili	NOUN
gs-3446	22	38	et	et	PROPN
gs-3446	22	39	al	al	PROPN
gs-3446	22	40	.	.	PROPN
gs-3446	22	41	,	,	PUNCT
gs-3446	22	42	2023	2023	NUM
gs-3446	22	43	)	)	PUNCT
gs-3446	22	44	.	.	PUNCT
gs-3446	23	1	the	the	DET
gs-3446	23	2	process	process	NOUN
gs-3446	23	3	of	of	ADP
gs-3446	23	4	regeneration	regeneration	NOUN
gs-3446	23	5	,	,	PUNCT
gs-3446	23	6	whether	whether	SCONJ
gs-3446	23	7	natural	natural	ADJ
gs-3446	23	8	or	or	CCONJ
gs-3446	23	9	induced	induce	VERB
gs-3446	23	10	,	,	PUNCT
gs-3446	23	11	relies	rely	VERB
gs-3446	23	12	heavily	heavily	ADV
gs-3446	23	13	on	on	ADP
gs-3446	23	14	the	the	DET
gs-3446	23	15	intrinsic	intrinsic	ADJ
gs-3446	23	16	properties	property	NOUN
gs-3446	23	17	of	of	ADP
gs-3446	23	18	stem	stem	NOUN
gs-3446	23	19	cells	cell	NOUN
gs-3446	23	20	and	and	CCONJ
gs-3446	23	21	their	their	PRON
gs-3446	23	22	ability	ability	NOUN
gs-3446	23	23	to	to	PART
gs-3446	23	24	respond	respond	VERB
gs-3446	23	25	to	to	ADP
gs-3446	23	26	physiological	physiological	ADJ
gs-3446	23	27	signals	signal	NOUN
gs-3446	23	28	.	.	PUNCT
gs-3446	24	1	in	in	ADP
gs-3446	24	2	organisms	organism	NOUN
gs-3446	24	3	with	with	ADP
gs-3446	24	4	high	high	ADJ
gs-3446	24	5	regenerative	regenerative	ADJ
gs-3446	24	6	capacities	capacity	NOUN
gs-3446	24	7	,	,	PUNCT
gs-3446	24	8	such	such	ADJ
gs-3446	24	9	as	as	ADP
gs-3446	24	10	certain	certain	ADJ
gs-3446	24	11	amphibians	amphibian	NOUN
gs-3446	24	12	and	and	CCONJ
gs-3446	24	13	invertebrates	invertebrate	NOUN
gs-3446	24	14	,	,	PUNCT
gs-3446	24	15	stem	stem	NOUN
gs-3446	24	16	cells	cell	NOUN
gs-3446	24	17	play	play	VERB
gs-3446	24	18	a	a	DET
gs-3446	24	19	crucial	crucial	ADJ
gs-3446	24	20	role	role	NOUN
gs-3446	24	21	in	in	ADP
gs-3446	24	22	restoring	restore	VERB
gs-3446	24	23	lost	lose	VERB
gs-3446	24	24	or	or	CCONJ
gs-3446	24	25	damaged	damaged	ADJ
gs-3446	24	26	tissues	tissue	NOUN
gs-3446	24	27	.	.	PUNCT
gs-3446	25	1	in	in	ADP
gs-3446	25	2	mammals	mammal	NOUN
gs-3446	25	3	,	,	PUNCT
gs-3446	25	4	however	however	ADV
gs-3446	25	5	,	,	PUNCT
gs-3446	25	6	regenerative	regenerative	ADJ
gs-3446	25	7	capabilities	capability	NOUN
gs-3446	25	8	vary	vary	VERB
gs-3446	25	9	widely	widely	ADV
gs-3446	25	10	among	among	ADP
gs-3446	25	11	different	different	ADJ
gs-3446	25	12	tissues	tissue	NOUN
gs-3446	25	13	.	.	PUNCT
gs-3446	26	1	for	for	ADP
gs-3446	26	2	instance	instance	NOUN
gs-3446	26	3	,	,	PUNCT
gs-3446	26	4	the	the	DET
gs-3446	26	5	liver	liver	NOUN
gs-3446	26	6	exhibits	exhibit	VERB
gs-3446	26	7	a	a	DET
gs-3446	26	8	remarkable	remarkable	ADJ
gs-3446	26	9	ability	ability	NOUN
gs-3446	26	10	to	to	PART
gs-3446	26	11	regenerate	regenerate	VERB
gs-3446	26	12	through	through	ADP
gs-3446	26	13	the	the	DET
gs-3446	26	14	proliferation	proliferation	NOUN
gs-3446	26	15	of	of	ADP
gs-3446	26	16	existing	exist	VERB
gs-3446	26	17	cells	cell	NOUN
gs-3446	26	18	,	,	PUNCT
gs-3446	26	19	whereas	whereas	SCONJ
gs-3446	26	20	the	the	DET
gs-3446	26	21	central	central	ADJ
gs-3446	26	22	nervous	nervous	ADJ
gs-3446	26	23	system	system	NOUN
gs-3446	26	24	has	have	VERB
gs-3446	26	25	a	a	DET
gs-3446	26	26	limited	limited	ADJ
gs-3446	26	27	capacity	capacity	NOUN
gs-3446	26	28	for	for	ADP
gs-3446	26	29	self	self	NOUN
gs-3446	26	30	-	-	PUNCT
gs-3446	26	31	repair	repair	NOUN
gs-3446	26	32	.	.	PUNCT
gs-3446	27	1	understanding	understand	VERB
gs-3446	27	2	the	the	DET
gs-3446	27	3	molecular	molecular	ADJ
gs-3446	27	4	and	and	CCONJ
gs-3446	27	5	genetic	genetic	ADJ
gs-3446	27	6	pathways	pathway	NOUN
gs-3446	27	7	that	that	PRON
gs-3446	27	8	regulate	regulate	VERB
gs-3446	27	9	stem	stem	NOUN
gs-3446	27	10	cell	cell	NOUN
gs-3446	27	11	activity	activity	NOUN
gs-3446	27	12	in	in	ADP
gs-3446	27	13	different	different	ADJ
gs-3446	27	14	tissues	tissue	NOUN
gs-3446	27	15	can	can	AUX
gs-3446	27	16	offer	offer	VERB
gs-3446	27	17	new	new	ADJ
gs-3446	27	18	insights	insight	NOUN
gs-3446	27	19	into	into	ADP
gs-3446	27	20	improving	improve	VERB
gs-3446	27	21	regenerative	regenerative	ADJ
gs-3446	27	22	responses	response	NOUN
gs-3446	27	23	in	in	ADP
gs-3446	27	24	humans	human	NOUN
gs-3446	27	25	.	.	PUNCT
gs-3446	28	1	scientists	scientist	NOUN
gs-3446	28	2	are	be	AUX
gs-3446	28	3	actively	actively	ADV
gs-3446	28	4	investigating	investigate	VERB
gs-3446	28	5	signaling	signal	VERB
gs-3446	28	6	pathways	pathway	NOUN
gs-3446	28	7	,	,	PUNCT
gs-3446	28	8	transcription	transcription	NOUN
gs-3446	28	9	factors	factor	NOUN
gs-3446	28	10	,	,	PUNCT
gs-3446	28	11	and	and	CCONJ
gs-3446	28	12	extracellular	extracellular	ADJ
gs-3446	28	13	cues	cue	NOUN
gs-3446	28	14	that	that	PRON
gs-3446	28	15	influence	influence	NOUN
gs-3446	28	16	stem	stem	NOUN
gs-3446	28	17	cell	cell	NOUN
gs-3446	28	18	behavior	behavior	NOUN
gs-3446	28	19	,	,	PUNCT
gs-3446	28	20	with	with	ADP
gs-3446	28	21	the	the	DET
gs-3446	28	22	goal	goal	NOUN
gs-3446	28	23	of	of	ADP
gs-3446	28	24	enhancing	enhance	VERB
gs-3446	28	25	tissue	tissue	NOUN
gs-3446	28	26	regeneration	regeneration	NOUN
gs-3446	28	27	in	in	ADP
gs-3446	28	28	clinical	clinical	ADJ
gs-3446	28	29	settings	setting	NOUN
gs-3446	28	30	.	.	PUNCT
gs-3446	29	1	in	in	ADP
gs-3446	29	2	addition	addition	NOUN
gs-3446	29	3	to	to	ADP
gs-3446	29	4	their	their	PRON
gs-3446	29	5	natural	natural	ADJ
gs-3446	29	6	role	role	NOUN
gs-3446	29	7	in	in	ADP
gs-3446	29	8	regeneration	regeneration	NOUN
gs-3446	29	9	,	,	PUNCT
gs-3446	29	10	stem	stem	NOUN
gs-3446	29	11	cells	cell	NOUN
gs-3446	29	12	are	be	AUX
gs-3446	29	13	being	be	AUX
gs-3446	29	14	explored	explore	VERB
gs-3446	29	15	for	for	ADP
gs-3446	29	16	their	their	PRON
gs-3446	29	17	potential	potential	NOUN
gs-3446	29	18	in	in	ADP
gs-3446	29	19	regenerative	regenerative	ADJ
gs-3446	29	20	medicine	medicine	NOUN
gs-3446	29	21	and	and	CCONJ
gs-3446	29	22	tissue	tissue	NOUN
gs-3446	29	23	engineering	engineering	NOUN
gs-3446	29	24	.	.	PUNCT
gs-3446	30	1	advances	advance	NOUN
gs-3446	30	2	in	in	ADP
gs-3446	30	3	biomaterials	biomaterial	NOUN
gs-3446	30	4	,	,	PUNCT
gs-3446	30	5	scaffolding	scaffold	VERB
gs-3446	30	6	techniques	technique	NOUN
gs-3446	30	7	,	,	PUNCT
gs-3446	30	8	and	and	CCONJ
gs-3446	30	9	gene	gene	NOUN
gs-3446	30	10	editing	editing	NOUN
gs-3446	30	11	technologies	technology	NOUN
gs-3446	30	12	have	have	AUX
gs-3446	30	13	enabled	enable	VERB
gs-3446	30	14	the	the	DET
gs-3446	30	15	development	development	NOUN
gs-3446	30	16	of	of	ADP
gs-3446	30	17	bioengineered	bioengineere	VERB
gs-3446	30	18	tissues	tissue	NOUN
gs-3446	30	19	and	and	CCONJ
gs-3446	30	20	organoids	organoid	NOUN
gs-3446	30	21	,	,	PUNCT
gs-3446	30	22	which	which	PRON
gs-3446	30	23	serve	serve	VERB
gs-3446	30	24	as	as	ADP
gs-3446	30	25	models	model	NOUN
gs-3446	30	26	for	for	ADP
gs-3446	30	27	studying	study	VERB
gs-3446	30	28	disease	disease	NOUN
gs-3446	30	29	progression	progression	NOUN
gs-3446	30	30	and	and	CCONJ
gs-3446	30	31	drug	drug	NOUN
gs-3446	30	32	responses	response	NOUN
gs-3446	30	33	.	.	PUNCT
gs-3446	31	1	clinical	clinical	ADJ
gs-3446	31	2	applications	application	NOUN
gs-3446	31	3	of	of	ADP
gs-3446	31	4	stem	stem	NOUN
gs-3446	31	5	cell	cell	NOUN
gs-3446	31	6	therapy	therapy	NOUN
gs-3446	31	7	are	be	AUX
gs-3446	31	8	being	be	AUX
gs-3446	31	9	investigated	investigate	VERB
gs-3446	31	10	for	for	ADP
gs-3446	31	11	conditions	condition	NOUN
gs-3446	31	12	such	such	ADJ
gs-3446	31	13	as	as	ADP
gs-3446	31	14	spinal	spinal	ADJ
gs-3446	31	15	cord	cord	NOUN
gs-3446	31	16	injuries	injury	NOUN
gs-3446	31	17	,	,	PUNCT
gs-3446	31	18	neurodegenerative	neurodegenerative	ADJ
gs-3446	31	19	diseases	disease	NOUN
gs-3446	31	20	,	,	PUNCT
gs-3446	31	21	georgian	georgian	ADJ
gs-3446	31	22	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3446	31	23	მეცნიერები	მეცნიერები	NOUN
gs-3446	31	24	ტ.	ტ.	VERB
gs-3446	31	25	7	7	NUM
gs-3446	31	26	n	n	PRON
gs-3446	31	27	1	1	NUM
gs-3446	31	28	,	,	PUNCT
gs-3446	31	29	2025	2025	NUM
gs-3446	31	30	273	273	NUM
gs-3446	31	31	cardiovascular	cardiovascular	ADJ
gs-3446	31	32	disorders	disorder	NOUN
gs-3446	31	33	,	,	PUNCT
gs-3446	31	34	and	and	CCONJ
gs-3446	31	35	diabetes	diabetes	NOUN
gs-3446	31	36	.	.	PUNCT
gs-3446	32	1	despite	despite	SCONJ
gs-3446	32	2	the	the	DET
gs-3446	32	3	promising	promising	ADJ
gs-3446	32	4	potential	potential	NOUN
gs-3446	32	5	,	,	PUNCT
gs-3446	32	6	several	several	ADJ
gs-3446	32	7	challenges	challenge	NOUN
gs-3446	32	8	must	must	AUX
gs-3446	32	9	be	be	AUX
gs-3446	32	10	addressed	address	VERB
gs-3446	32	11	,	,	PUNCT
gs-3446	32	12	including	include	VERB
gs-3446	32	13	ensuring	ensure	VERB
gs-3446	32	14	the	the	DET
gs-3446	32	15	safety	safety	NOUN
gs-3446	32	16	,	,	PUNCT
gs-3446	32	17	efficacy	efficacy	NOUN
gs-3446	32	18	,	,	PUNCT
gs-3446	32	19	and	and	CCONJ
gs-3446	32	20	ethical	ethical	ADJ
gs-3446	32	21	considerations	consideration	NOUN
gs-3446	32	22	of	of	ADP
gs-3446	32	23	stem	stem	NOUN
gs-3446	32	24	cell	cell	NOUN
gs-3446	32	25	-	-	PUNCT
gs-3446	32	26	based	base	VERB
gs-3446	32	27	therapies	therapy	NOUN
gs-3446	32	28	.	.	PUNCT
gs-3446	33	1	tumorigenicity	tumorigenicity	NOUN
gs-3446	33	2	,	,	PUNCT
gs-3446	33	3	immune	immune	ADJ
gs-3446	33	4	rejection	rejection	NOUN
gs-3446	33	5	,	,	PUNCT
gs-3446	33	6	and	and	CCONJ
gs-3446	33	7	uncontrolled	uncontrolled	ADJ
gs-3446	33	8	differentiation	differentiation	NOUN
gs-3446	33	9	remain	remain	VERB
gs-3446	33	10	significant	significant	ADJ
gs-3446	33	11	hurdles	hurdle	NOUN
gs-3446	33	12	that	that	PRON
gs-3446	33	13	must	must	AUX
gs-3446	33	14	be	be	AUX
gs-3446	33	15	overcome	overcome	VERB
gs-3446	33	16	before	before	ADP
gs-3446	33	17	widespread	widespread	ADJ
gs-3446	33	18	clinical	clinical	ADJ
gs-3446	33	19	implementation	implementation	NOUN
gs-3446	33	20	(	(	PUNCT
gs-3446	33	21	sulashvili	sulashvili	NOUN
gs-3446	33	22	et	et	PROPN
gs-3446	33	23	al	al	PROPN
gs-3446	33	24	.	.	PROPN
gs-3446	33	25	,	,	PUNCT
gs-3446	33	26	2024	2024	NUM
gs-3446	33	27	)	)	PUNCT
gs-3446	33	28	.	.	PUNCT
gs-3446	34	1	the	the	DET
gs-3446	34	2	characteristics	characteristic	NOUN
gs-3446	34	3	of	of	ADP
gs-3446	34	4	stem	stem	NOUN
gs-3446	34	5	cell	cell	NOUN
gs-3446	34	6	systems	system	NOUN
gs-3446	34	7	and	and	CCONJ
gs-3446	34	8	their	their	PRON
gs-3446	34	9	regenerative	regenerative	ADJ
gs-3446	34	10	capabilities	capability	NOUN
gs-3446	34	11	present	present	VERB
gs-3446	34	12	a	a	DET
gs-3446	34	13	frontier	frontier	NOUN
gs-3446	34	14	in	in	ADP
gs-3446	34	15	biological	biological	ADJ
gs-3446	34	16	research	research	NOUN
gs-3446	34	17	and	and	CCONJ
gs-3446	34	18	medical	medical	ADJ
gs-3446	34	19	innovation	innovation	NOUN
gs-3446	34	20	.	.	PUNCT
gs-3446	35	1	by	by	ADP
gs-3446	35	2	elucidating	elucidate	VERB
gs-3446	35	3	the	the	DET
gs-3446	35	4	molecular	molecular	ADJ
gs-3446	35	5	mechanisms	mechanism	NOUN
gs-3446	35	6	underlying	underlie	VERB
gs-3446	35	7	stem	stem	NOUN
gs-3446	35	8	cell	cell	NOUN
gs-3446	35	9	function	function	NOUN
gs-3446	35	10	,	,	PUNCT
gs-3446	35	11	scientists	scientist	NOUN
gs-3446	35	12	hope	hope	VERB
gs-3446	35	13	to	to	PART
gs-3446	35	14	unlock	unlock	VERB
gs-3446	35	15	new	new	ADJ
gs-3446	35	16	possibilities	possibility	NOUN
gs-3446	35	17	for	for	ADP
gs-3446	35	18	regenerative	regenerative	ADJ
gs-3446	35	19	therapies	therapy	NOUN
gs-3446	35	20	that	that	PRON
gs-3446	35	21	can	can	AUX
gs-3446	35	22	restore	restore	VERB
gs-3446	35	23	tissue	tissue	NOUN
gs-3446	35	24	function	function	NOUN
gs-3446	35	25	,	,	PUNCT
gs-3446	35	26	repair	repair	NOUN
gs-3446	35	27	injuries	injury	NOUN
gs-3446	35	28	,	,	PUNCT
gs-3446	35	29	and	and	CCONJ
gs-3446	35	30	combat	combat	NOUN
gs-3446	35	31	degenerative	degenerative	ADJ
gs-3446	35	32	diseases	disease	NOUN
gs-3446	35	33	.	.	PUNCT
gs-3446	36	1	continued	continue	VERB
gs-3446	36	2	advancements	advancement	NOUN
gs-3446	36	3	in	in	ADP
gs-3446	36	4	stem	stem	NOUN
gs-3446	36	5	cell	cell	NOUN
gs-3446	36	6	research	research	NOUN
gs-3446	36	7	,	,	PUNCT
gs-3446	36	8	coupled	couple	VERB
gs-3446	36	9	with	with	ADP
gs-3446	36	10	technological	technological	ADJ
gs-3446	36	11	innovations	innovation	NOUN
gs-3446	36	12	,	,	PUNCT
gs-3446	36	13	hold	hold	VERB
gs-3446	36	14	the	the	DET
gs-3446	36	15	promise	promise	NOUN
gs-3446	36	16	of	of	ADP
gs-3446	36	17	revolutionizing	revolutionize	VERB
gs-3446	36	18	medicine	medicine	NOUN
gs-3446	36	19	and	and	CCONJ
gs-3446	36	20	improving	improve	VERB
gs-3446	36	21	the	the	DET
gs-3446	36	22	quality	quality	NOUN
gs-3446	36	23	of	of	ADP
gs-3446	36	24	life	life	NOUN
gs-3446	36	25	for	for	ADP
gs-3446	36	26	millions	million	NOUN
gs-3446	36	27	of	of	ADP
gs-3446	36	28	individuals	individual	NOUN
gs-3446	36	29	worldwide	worldwide	ADV
gs-3446	36	30	.	.	PUNCT
gs-3446	37	1	as	as	SCONJ
gs-3446	37	2	research	research	NOUN
gs-3446	37	3	progresses	progress	NOUN
gs-3446	37	4	,	,	PUNCT
gs-3446	37	5	the	the	DET
gs-3446	37	6	integration	integration	NOUN
gs-3446	37	7	of	of	ADP
gs-3446	37	8	stem	stem	NOUN
gs-3446	37	9	cell	cell	NOUN
gs-3446	37	10	-	-	PUNCT
gs-3446	37	11	based	base	VERB
gs-3446	37	12	approaches	approach	NOUN
gs-3446	37	13	into	into	ADP
gs-3446	37	14	clinical	clinical	ADJ
gs-3446	37	15	practice	practice	NOUN
gs-3446	37	16	will	will	AUX
gs-3446	37	17	require	require	VERB
gs-3446	37	18	interdisciplinary	interdisciplinary	ADJ
gs-3446	37	19	collaboration	collaboration	NOUN
gs-3446	37	20	,	,	PUNCT
gs-3446	37	21	ethical	ethical	ADJ
gs-3446	37	22	considerations	consideration	NOUN
gs-3446	37	23	,	,	PUNCT
gs-3446	37	24	and	and	CCONJ
gs-3446	37	25	rigorous	rigorous	ADJ
gs-3446	37	26	regulatory	regulatory	ADJ
gs-3446	37	27	oversight	oversight	NOUN
gs-3446	37	28	to	to	PART
gs-3446	37	29	ensure	ensure	VERB
gs-3446	37	30	safe	safe	ADJ
gs-3446	37	31	and	and	CCONJ
gs-3446	37	32	effective	effective	ADJ
gs-3446	37	33	applications	application	NOUN
gs-3446	37	34	.	.	PUNCT
gs-3446	38	1	the	the	DET
gs-3446	38	2	exploration	exploration	NOUN
gs-3446	38	3	of	of	ADP
gs-3446	38	4	stem	stem	NOUN
gs-3446	38	5	cell	cell	NOUN
gs-3446	38	6	systems	system	NOUN
gs-3446	38	7	thus	thus	ADV
gs-3446	38	8	represents	represent	VERB
gs-3446	38	9	a	a	DET
gs-3446	38	10	crucial	crucial	ADJ
gs-3446	38	11	step	step	NOUN
gs-3446	38	12	toward	toward	ADP
gs-3446	38	13	realizing	realize	VERB
gs-3446	38	14	the	the	DET
gs-3446	38	15	full	full	ADJ
gs-3446	38	16	potential	potential	NOUN
gs-3446	38	17	of	of	ADP
gs-3446	38	18	regenerative	regenerative	ADJ
gs-3446	38	19	medicine	medicine	NOUN
gs-3446	38	20	in	in	ADP
gs-3446	38	21	the	the	DET
gs-3446	38	22	modern	modern	ADJ
gs-3446	38	23	era	era	NOUN
gs-3446	38	24	(	(	PUNCT
gs-3446	38	25	sulashvili	sulashvili	NOUN
gs-3446	38	26	et	et	PROPN
gs-3446	38	27	al	al	PROPN
gs-3446	38	28	.	.	PROPN
gs-3446	38	29	,	,	PUNCT
gs-3446	38	30	2024	2024	NUM
gs-3446	38	31	)	)	PUNCT
gs-3446	38	32	.	.	PUNCT
gs-3446	39	1	stem	stem	NOUN
gs-3446	39	2	cells	cell	NOUN
gs-3446	39	3	are	be	AUX
gs-3446	39	4	unique	unique	ADJ
gs-3446	39	5	biological	biological	ADJ
gs-3446	39	6	cells	cell	NOUN
gs-3446	39	7	with	with	ADP
gs-3446	39	8	the	the	DET
gs-3446	39	9	capacity	capacity	NOUN
gs-3446	39	10	for	for	ADP
gs-3446	39	11	self	self	NOUN
gs-3446	39	12	-	-	PUNCT
gs-3446	39	13	renewal	renewal	NOUN
gs-3446	39	14	and	and	CCONJ
gs-3446	39	15	differentiation	differentiation	NOUN
gs-3446	39	16	into	into	ADP
gs-3446	39	17	specialized	specialized	ADJ
gs-3446	39	18	cell	cell	NOUN
gs-3446	39	19	types	type	NOUN
gs-3446	39	20	.	.	PUNCT
gs-3446	40	1	they	they	PRON
gs-3446	40	2	play	play	VERB
gs-3446	40	3	a	a	DET
gs-3446	40	4	crucial	crucial	ADJ
gs-3446	40	5	role	role	NOUN
gs-3446	40	6	in	in	ADP
gs-3446	40	7	embryonic	embryonic	ADJ
gs-3446	40	8	development	development	NOUN
gs-3446	40	9	,	,	PUNCT
gs-3446	40	10	tissue	tissue	NOUN
gs-3446	40	11	maintenance	maintenance	NOUN
gs-3446	40	12	,	,	PUNCT
gs-3446	40	13	and	and	CCONJ
gs-3446	40	14	regeneration	regeneration	NOUN
gs-3446	40	15	.	.	PUNCT
gs-3446	41	1	the	the	DET
gs-3446	41	2	study	study	NOUN
gs-3446	41	3	of	of	ADP
gs-3446	41	4	stem	stem	NOUN
gs-3446	41	5	cell	cell	NOUN
gs-3446	41	6	systems	system	NOUN
gs-3446	41	7	has	have	AUX
gs-3446	41	8	opened	open	VERB
gs-3446	41	9	new	new	ADJ
gs-3446	41	10	avenues	avenue	NOUN
gs-3446	41	11	for	for	ADP
gs-3446	41	12	regenerative	regenerative	ADJ
gs-3446	41	13	medicine	medicine	NOUN
gs-3446	41	14	,	,	PUNCT
gs-3446	41	15	offering	offer	VERB
gs-3446	41	16	promising	promising	ADJ
gs-3446	41	17	prospects	prospect	NOUN
gs-3446	41	18	for	for	ADP
gs-3446	41	19	treating	treat	VERB
gs-3446	41	20	various	various	ADJ
gs-3446	41	21	degenerative	degenerative	ADJ
gs-3446	41	22	diseases	disease	NOUN
gs-3446	41	23	,	,	PUNCT
gs-3446	41	24	injuries	injury	NOUN
gs-3446	41	25	,	,	PUNCT
gs-3446	41	26	and	and	CCONJ
gs-3446	41	27	organ	organ	NOUN
gs-3446	41	28	failures	failure	NOUN
gs-3446	41	29	(	(	PUNCT
gs-3446	41	30	gorgaslidze	gorgaslidze	ADJ
gs-3446	41	31	and	and	CCONJ
gs-3446	41	32	sulashvili	sulashvili	NOUN
gs-3446	41	33	et	et	PROPN
gs-3446	41	34	al	al	PROPN
gs-3446	41	35	.	.	PROPN
gs-3446	41	36	,	,	PUNCT
gs-3446	41	37	2023	2023	NUM
gs-3446	41	38	)	)	PUNCT
gs-3446	41	39	features	feature	NOUN
gs-3446	41	40	and	and	CCONJ
gs-3446	41	41	characteristics	characteristic	NOUN
gs-3446	41	42	of	of	ADP
gs-3446	41	43	stem	stem	NOUN
gs-3446	41	44	cells	cell	NOUN
gs-3446	41	45	stem	stem	VERB
gs-3446	41	46	cells	cell	NOUN
gs-3446	41	47	are	be	AUX
gs-3446	41	48	classified	classify	VERB
gs-3446	41	49	based	base	VERB
gs-3446	41	50	on	on	ADP
gs-3446	41	51	their	their	PRON
gs-3446	41	52	potency	potency	NOUN
gs-3446	41	53	and	and	CCONJ
gs-3446	41	54	source	source	NOUN
gs-3446	41	55	:	:	PUNCT
gs-3446	41	56	1	1	NUM
gs-3446	41	57	.	.	NOUN
gs-3446	41	58	potency	potency	NOUN
gs-3446	41	59	levels	level	NOUN
gs-3446	41	60	:	:	PUNCT
gs-3446	41	61	○	○	ADJ
gs-3446	41	62	totipotent	totipotent	ADJ
gs-3446	41	63	stem	stem	NOUN
gs-3446	41	64	cells	cell	NOUN
gs-3446	41	65	:	:	PUNCT
gs-3446	41	66	these	these	DET
gs-3446	41	67	cells	cell	NOUN
gs-3446	41	68	can	can	AUX
gs-3446	41	69	differentiate	differentiate	VERB
gs-3446	41	70	into	into	ADP
gs-3446	41	71	all	all	DET
gs-3446	41	72	cell	cell	NOUN
gs-3446	41	73	types	type	NOUN
gs-3446	41	74	,	,	PUNCT
gs-3446	41	75	including	include	VERB
gs-3446	41	76	extraembryonic	extraembryonic	ADJ
gs-3446	41	77	tissues	tissue	NOUN
gs-3446	41	78	(	(	PUNCT
gs-3446	41	79	e.g.	e.g.	ADV
gs-3446	41	80	,	,	PUNCT
gs-3446	41	81	zygote	zygote	ADJ
gs-3446	41	82	and	and	CCONJ
gs-3446	41	83	early	early	ADJ
gs-3446	41	84	blastomeres	blastomere	NOUN
gs-3446	41	85	)	)	PUNCT
gs-3446	41	86	.	.	PUNCT
gs-3446	42	1	○	○	ADJ
gs-3446	42	2	pluripotent	pluripotent	ADJ
gs-3446	42	3	stem	stem	NOUN
gs-3446	42	4	cells	cell	NOUN
gs-3446	42	5	:	:	PUNCT
gs-3446	42	6	these	these	PRON
gs-3446	42	7	can	can	AUX
gs-3446	42	8	give	give	VERB
gs-3446	42	9	rise	rise	NOUN
gs-3446	42	10	to	to	ADP
gs-3446	42	11	cells	cell	NOUN
gs-3446	42	12	from	from	ADP
gs-3446	42	13	all	all	DET
gs-3446	42	14	three	three	NUM
gs-3446	42	15	germ	germ	NOUN
gs-3446	42	16	layers	layer	NOUN
gs-3446	42	17	(	(	PUNCT
gs-3446	42	18	ectoderm	ectoderm	NOUN
gs-3446	42	19	,	,	PUNCT
gs-3446	42	20	mesoderm	mesoderm	NOUN
gs-3446	42	21	,	,	PUNCT
gs-3446	42	22	and	and	CCONJ
gs-3446	42	23	endoderm	endoderm	NOUN
gs-3446	42	24	)	)	PUNCT
gs-3446	42	25	but	but	CCONJ
gs-3446	42	26	not	not	PART
gs-3446	42	27	extra	extra	ADJ
gs-3446	42	28	-	-	ADJ
gs-3446	42	29	embryonic	embryonic	ADJ
gs-3446	42	30	tissues	tissue	NOUN
gs-3446	42	31	(	(	PUNCT
gs-3446	42	32	e.g.	e.g.	ADV
gs-3446	42	33	,	,	PUNCT
gs-3446	42	34	embryonic	embryonic	ADJ
gs-3446	42	35	stem	stem	NOUN
gs-3446	42	36	cells	cell	NOUN
gs-3446	42	37	)	)	PUNCT
gs-3446	42	38	.	.	PUNCT
gs-3446	43	1	○	○	ADJ
gs-3446	43	2	multipotent	multipotent	NOUN
gs-3446	43	3	stem	stem	NOUN
gs-3446	43	4	cells	cell	NOUN
gs-3446	43	5	:	:	PUNCT
gs-3446	43	6	these	these	PRON
gs-3446	43	7	have	have	VERB
gs-3446	43	8	a	a	DET
gs-3446	43	9	more	more	ADV
gs-3446	43	10	limited	limited	ADJ
gs-3446	43	11	differentiation	differentiation	NOUN
gs-3446	43	12	potential	potential	NOUN
gs-3446	43	13	,	,	PUNCT
gs-3446	43	14	giving	give	VERB
gs-3446	43	15	rise	rise	NOUN
gs-3446	43	16	to	to	ADP
gs-3446	43	17	cell	cell	NOUN
gs-3446	43	18	types	type	NOUN
gs-3446	43	19	within	within	ADP
gs-3446	43	20	a	a	DET
gs-3446	43	21	specific	specific	ADJ
gs-3446	43	22	lineage	lineage	NOUN
gs-3446	43	23	(	(	PUNCT
gs-3446	43	24	e.g.	e.g.	ADV
gs-3446	43	25	,	,	PUNCT
gs-3446	43	26	hematopoietic	hematopoietic	ADJ
gs-3446	43	27	stem	stem	NOUN
gs-3446	43	28	cells	cell	NOUN
gs-3446	43	29	,	,	PUNCT
gs-3446	43	30	mesenchymal	mesenchymal	ADJ
gs-3446	43	31	stem	stem	NOUN
gs-3446	43	32	cells	cell	NOUN
gs-3446	43	33	)	)	PUNCT
gs-3446	43	34	.	.	PUNCT
gs-3446	44	1	○	○	ADJ
gs-3446	44	2	unipotent	unipotent	ADJ
gs-3446	44	3	stem	stem	NOUN
gs-3446	44	4	cells	cell	NOUN
gs-3446	44	5	:	:	PUNCT
gs-3446	44	6	these	these	PRON
gs-3446	44	7	can	can	AUX
gs-3446	44	8	only	only	ADV
gs-3446	44	9	differentiate	differentiate	VERB
gs-3446	44	10	into	into	ADP
gs-3446	44	11	one	one	NUM
gs-3446	44	12	specific	specific	ADJ
gs-3446	44	13	cell	cell	NOUN
gs-3446	44	14	type	type	NOUN
gs-3446	44	15	but	but	CCONJ
gs-3446	44	16	retain	retain	VERB
gs-3446	44	17	the	the	DET
gs-3446	44	18	ability	ability	NOUN
gs-3446	44	19	for	for	ADP
gs-3446	44	20	self	self	NOUN
gs-3446	44	21	-	-	PUNCT
gs-3446	44	22	renewal	renewal	NOUN
gs-3446	44	23	(	(	PUNCT
gs-3446	44	24	e.g.	e.g.	ADV
gs-3446	44	25	,	,	PUNCT
gs-3446	44	26	epidermal	epidermal	ADJ
gs-3446	44	27	stem	stem	NOUN
gs-3446	44	28	cells	cell	NOUN
gs-3446	44	29	)	)	PUNCT
gs-3446	44	30	.	.	PUNCT
gs-3446	45	1	2	2	X
gs-3446	45	2	.	.	X
gs-3446	45	3	sources	source	NOUN
gs-3446	45	4	of	of	ADP
gs-3446	45	5	stem	stem	NOUN
gs-3446	45	6	cells	cell	NOUN
gs-3446	45	7	:	:	PUNCT
gs-3446	45	8	○	○	ADJ
gs-3446	45	9	embryonic	embryonic	ADJ
gs-3446	45	10	stem	stem	NOUN
gs-3446	45	11	cells	cell	NOUN
gs-3446	45	12	(	(	PUNCT
gs-3446	45	13	escs	esc	NOUN
gs-3446	45	14	):	):	PUNCT
gs-3446	45	15	derived	derive	VERB
gs-3446	45	16	from	from	ADP
gs-3446	45	17	the	the	DET
gs-3446	45	18	inner	inner	ADJ
gs-3446	45	19	cell	cell	NOUN
gs-3446	45	20	mass	mass	NOUN
gs-3446	45	21	of	of	ADP
gs-3446	45	22	the	the	DET
gs-3446	45	23	blastocyst	blastocyst	NOUN
gs-3446	45	24	,	,	PUNCT
gs-3446	45	25	escs	esc	NOUN
gs-3446	45	26	have	have	VERB
gs-3446	45	27	high	high	ADJ
gs-3446	45	28	pluripotency	pluripotency	NOUN
gs-3446	45	29	but	but	CCONJ
gs-3446	45	30	face	face	VERB
gs-3446	45	31	ethical	ethical	ADJ
gs-3446	45	32	concerns	concern	NOUN
gs-3446	45	33	and	and	CCONJ
gs-3446	45	34	risk	risk	NOUN
gs-3446	45	35	of	of	ADP
gs-3446	45	36	tumorigenicity	tumorigenicity	NOUN
gs-3446	45	37	.	.	PUNCT
gs-3446	46	1	○	○	PROPN
gs-3446	46	2	adult	adult	NOUN
gs-3446	46	3	stem	stem	NOUN
gs-3446	46	4	cells	cell	NOUN
gs-3446	46	5	(	(	PUNCT
gs-3446	46	6	ascs	asc	NOUN
gs-3446	46	7	):	):	PUNCT
gs-3446	46	8	found	find	VERB
gs-3446	46	9	in	in	ADP
gs-3446	46	10	specific	specific	ADJ
gs-3446	46	11	tissues	tissue	NOUN
gs-3446	46	12	(	(	PUNCT
gs-3446	46	13	e.g.	e.g.	ADV
gs-3446	46	14	,	,	PUNCT
gs-3446	46	15	bone	bone	NOUN
gs-3446	46	16	marrow	marrow	NOUN
gs-3446	46	17	,	,	PUNCT
gs-3446	46	18	skin	skin	NOUN
gs-3446	46	19	,	,	PUNCT
gs-3446	46	20	liver	liver	NOUN
gs-3446	46	21	)	)	PUNCT
gs-3446	46	22	,	,	PUNCT
gs-3446	46	23	these	these	DET
gs-3446	46	24	stem	stem	NOUN
gs-3446	46	25	cells	cell	NOUN
gs-3446	46	26	have	have	VERB
gs-3446	46	27	limited	limit	VERB
gs-3446	46	28	differentiation	differentiation	NOUN
gs-3446	46	29	capacity	capacity	NOUN
gs-3446	46	30	and	and	CCONJ
gs-3446	46	31	primarily	primarily	ADV
gs-3446	46	32	contribute	contribute	VERB
gs-3446	46	33	to	to	ADP
gs-3446	46	34	tissue	tissue	NOUN
gs-3446	46	35	homeostasis	homeostasis	NOUN
gs-3446	46	36	and	and	CCONJ
gs-3446	46	37	repair	repair	NOUN
gs-3446	46	38	.	.	PUNCT
gs-3446	47	1	georgian	georgian	ADJ
gs-3446	47	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	47	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	47	4	ტ.	ტ.	VERB
gs-3446	47	5	7	7	NUM
gs-3446	47	6	n	n	PRON
gs-3446	47	7	1	1	NUM
gs-3446	47	8	,	,	PUNCT
gs-3446	47	9	2025	2025	NUM
gs-3446	47	10	274	274	NUM
gs-3446	47	11	○	○	ADJ
gs-3446	47	12	induced	induce	VERB
gs-3446	47	13	pluripotent	pluripotent	ADJ
gs-3446	47	14	stem	stem	NOUN
gs-3446	47	15	cells	cell	NOUN
gs-3446	47	16	(	(	PUNCT
gs-3446	47	17	ipscs	ipsc	NOUN
gs-3446	47	18	):	):	PUNCT
gs-3446	47	19	reprogrammed	reprogramme	VERB
gs-3446	47	20	from	from	ADP
gs-3446	47	21	somatic	somatic	ADJ
gs-3446	47	22	cells	cell	NOUN
gs-3446	47	23	using	use	VERB
gs-3446	47	24	genetic	genetic	ADJ
gs-3446	47	25	factors	factor	NOUN
gs-3446	47	26	,	,	PUNCT
gs-3446	47	27	ipscs	ipscs	NOUN
gs-3446	47	28	exhibit	exhibit	VERB
gs-3446	47	29	pluripotency	pluripotency	NOUN
gs-3446	47	30	similar	similar	ADJ
gs-3446	47	31	to	to	ADP
gs-3446	47	32	escs	esc	NOUN
gs-3446	47	33	while	while	SCONJ
gs-3446	47	34	avoiding	avoid	VERB
gs-3446	47	35	ethical	ethical	ADJ
gs-3446	47	36	concerns	concern	NOUN
gs-3446	47	37	(	(	PUNCT
gs-3446	47	38	halpern	halpern	PROPN
gs-3446	47	39	et	et	PROPN
gs-3446	47	40	al	al	PROPN
gs-3446	47	41	.	.	PROPN
gs-3446	47	42	2019	2019	NUM
gs-3446	47	43	)	)	PUNCT
gs-3446	47	44	.	.	PUNCT
gs-3446	48	1	regeneration	regeneration	NOUN
gs-3446	48	2	prospects	prospect	NOUN
gs-3446	48	3	and	and	CCONJ
gs-3446	48	4	applications	application	NOUN
gs-3446	48	5	stem	stem	NOUN
gs-3446	48	6	cells	cell	NOUN
gs-3446	48	7	hold	hold	VERB
gs-3446	48	8	immense	immense	ADJ
gs-3446	48	9	potential	potential	NOUN
gs-3446	48	10	in	in	ADP
gs-3446	48	11	regenerative	regenerative	ADJ
gs-3446	48	12	medicine	medicine	NOUN
gs-3446	48	13	,	,	PUNCT
gs-3446	48	14	with	with	ADP
gs-3446	48	15	applications	application	NOUN
gs-3446	48	16	spanning	span	VERB
gs-3446	48	17	various	various	ADJ
gs-3446	48	18	fields	field	NOUN
gs-3446	48	19	:	:	PUNCT
gs-3446	48	20	1	1	X
gs-3446	48	21	.	.	X
gs-3446	48	22	tissue	tissue	NOUN
gs-3446	48	23	engineering	engineering	NOUN
gs-3446	48	24	and	and	CCONJ
gs-3446	48	25	organ	organ	NOUN
gs-3446	48	26	regeneration	regeneration	NOUN
gs-3446	48	27	:	:	PUNCT
gs-3446	48	28	stem	stem	NOUN
gs-3446	48	29	cells	cell	NOUN
gs-3446	48	30	contribute	contribute	VERB
gs-3446	48	31	to	to	ADP
gs-3446	48	32	the	the	DET
gs-3446	48	33	development	development	NOUN
gs-3446	48	34	of	of	ADP
gs-3446	48	35	bioengineered	bioengineere	VERB
gs-3446	48	36	tissues	tissue	NOUN
gs-3446	48	37	and	and	CCONJ
gs-3446	48	38	organs	organ	NOUN
gs-3446	48	39	,	,	PUNCT
gs-3446	48	40	offering	offer	VERB
gs-3446	48	41	potential	potential	ADJ
gs-3446	48	42	solutions	solution	NOUN
gs-3446	48	43	for	for	ADP
gs-3446	48	44	organ	organ	NOUN
gs-3446	48	45	transplantation	transplantation	NOUN
gs-3446	48	46	shortages	shortage	NOUN
gs-3446	48	47	.	.	PUNCT
gs-3446	49	1	2	2	X
gs-3446	49	2	.	.	NOUN
gs-3446	49	3	neurodegenerative	neurodegenerative	ADJ
gs-3446	49	4	diseases	disease	NOUN
gs-3446	49	5	:	:	PUNCT
gs-3446	49	6	ipsc	ipsc	NOUN
gs-3446	49	7	-	-	PUNCT
gs-3446	49	8	derived	derive	VERB
gs-3446	49	9	neural	neural	ADJ
gs-3446	49	10	cells	cell	NOUN
gs-3446	49	11	provide	provide	VERB
gs-3446	49	12	promising	promise	VERB
gs-3446	49	13	therapeutic	therapeutic	ADJ
gs-3446	49	14	strategies	strategy	NOUN
gs-3446	49	15	for	for	ADP
gs-3446	49	16	conditions	condition	NOUN
gs-3446	49	17	such	such	ADJ
gs-3446	49	18	as	as	ADP
gs-3446	49	19	parkinson	parkinson	NOUN
gs-3446	49	20	’s	’s	PART
gs-3446	49	21	disease	disease	NOUN
gs-3446	49	22	,	,	PUNCT
gs-3446	49	23	alzheimer	alzheimer	PROPN
gs-3446	49	24	’s	’s	PART
gs-3446	49	25	disease	disease	NOUN
gs-3446	49	26	,	,	PUNCT
gs-3446	49	27	and	and	CCONJ
gs-3446	49	28	spinal	spinal	ADJ
gs-3446	49	29	cord	cord	NOUN
gs-3446	49	30	injuries	injury	NOUN
gs-3446	49	31	.	.	PUNCT
gs-3446	50	1	3	3	X
gs-3446	50	2	.	.	X
gs-3446	50	3	cardiac	cardiac	ADJ
gs-3446	50	4	repair	repair	NOUN
gs-3446	50	5	:	:	PUNCT
gs-3446	50	6	stem	stem	NOUN
gs-3446	50	7	cell	cell	NOUN
gs-3446	50	8	therapies	therapy	NOUN
gs-3446	50	9	aim	aim	VERB
gs-3446	50	10	to	to	PART
gs-3446	50	11	regenerate	regenerate	VERB
gs-3446	50	12	damaged	damage	VERB
gs-3446	50	13	myocardium	myocardium	NOUN
gs-3446	50	14	in	in	ADP
gs-3446	50	15	patients	patient	NOUN
gs-3446	50	16	with	with	ADP
gs-3446	50	17	heart	heart	NOUN
gs-3446	50	18	disease	disease	NOUN
gs-3446	50	19	,	,	PUNCT
gs-3446	50	20	enhancing	enhance	VERB
gs-3446	50	21	cardiac	cardiac	ADJ
gs-3446	50	22	function	function	NOUN
gs-3446	50	23	.	.	PUNCT
gs-3446	51	1	4	4	X
gs-3446	51	2	.	.	X
gs-3446	51	3	diabetes	diabetes	NOUN
gs-3446	51	4	treatment	treatment	NOUN
gs-3446	51	5	:	:	PUNCT
gs-3446	51	6	ipsc	ipsc	NOUN
gs-3446	51	7	-	-	PUNCT
gs-3446	51	8	derived	derive	VERB
gs-3446	51	9	pancreatic	pancreatic	ADJ
gs-3446	51	10	beta	beta	NOUN
gs-3446	51	11	cells	cell	NOUN
gs-3446	51	12	show	show	VERB
gs-3446	51	13	potential	potential	NOUN
gs-3446	51	14	in	in	ADP
gs-3446	51	15	restoring	restore	VERB
gs-3446	51	16	insulin	insulin	NOUN
gs-3446	51	17	production	production	NOUN
gs-3446	51	18	for	for	ADP
gs-3446	51	19	diabetic	diabetic	ADJ
gs-3446	51	20	patients	patient	NOUN
gs-3446	51	21	.	.	PUNCT
gs-3446	52	1	5	5	X
gs-3446	52	2	.	.	X
gs-3446	52	3	bone	bone	NOUN
gs-3446	52	4	and	and	CCONJ
gs-3446	52	5	cartilage	cartilage	NOUN
gs-3446	52	6	regeneration	regeneration	NOUN
gs-3446	52	7	:	:	PUNCT
gs-3446	52	8	mesenchymal	mesenchymal	ADJ
gs-3446	52	9	stem	stem	NOUN
gs-3446	52	10	cells	cell	NOUN
gs-3446	52	11	(	(	PUNCT
gs-3446	52	12	mscs	msc	NOUN
gs-3446	52	13	)	)	PUNCT
gs-3446	52	14	facilitate	facilitate	NOUN
gs-3446	52	15	bone	bone	NOUN
gs-3446	52	16	repair	repair	NOUN
gs-3446	52	17	and	and	CCONJ
gs-3446	52	18	cartilage	cartilage	NOUN
gs-3446	52	19	regeneration	regeneration	NOUN
gs-3446	52	20	in	in	ADP
gs-3446	52	21	orthopedic	orthopedic	ADJ
gs-3446	52	22	and	and	CCONJ
gs-3446	52	23	osteoarthritic	osteoarthritic	ADJ
gs-3446	52	24	treatments	treatment	NOUN
gs-3446	52	25	.	.	PUNCT
gs-3446	53	1	6	6	NUM
gs-3446	53	2	.	.	X
gs-3446	53	3	cancer	cancer	NOUN
gs-3446	53	4	treatment	treatment	NOUN
gs-3446	53	5	:	:	PUNCT
gs-3446	53	6	stem	stem	VERB
gs-3446	53	7	cell	cell	NOUN
gs-3446	53	8	-	-	PUNCT
gs-3446	53	9	based	base	VERB
gs-3446	53	10	therapies	therapy	NOUN
gs-3446	53	11	,	,	PUNCT
gs-3446	53	12	such	such	ADJ
gs-3446	53	13	as	as	ADP
gs-3446	53	14	hematopoietic	hematopoietic	ADJ
gs-3446	53	15	stem	stem	NOUN
gs-3446	53	16	cell	cell	NOUN
gs-3446	53	17	transplantation	transplantation	NOUN
gs-3446	53	18	,	,	PUNCT
gs-3446	53	19	are	be	AUX
gs-3446	53	20	widely	widely	ADV
gs-3446	53	21	used	use	VERB
gs-3446	53	22	in	in	ADP
gs-3446	53	23	leukemia	leukemia	NOUN
gs-3446	53	24	treatment	treatment	NOUN
gs-3446	53	25	.	.	PUNCT
gs-3446	54	1	despite	despite	SCONJ
gs-3446	54	2	significant	significant	ADJ
gs-3446	54	3	advancements	advancement	NOUN
gs-3446	54	4	,	,	PUNCT
gs-3446	54	5	challenges	challenge	NOUN
gs-3446	54	6	remain	remain	VERB
gs-3446	54	7	,	,	PUNCT
gs-3446	54	8	including	include	VERB
gs-3446	54	9	immune	immune	ADJ
gs-3446	54	10	rejection	rejection	NOUN
gs-3446	54	11	,	,	PUNCT
gs-3446	54	12	tumorigenicity	tumorigenicity	NOUN
gs-3446	54	13	,	,	PUNCT
gs-3446	54	14	ethical	ethical	ADJ
gs-3446	54	15	concerns	concern	NOUN
gs-3446	54	16	,	,	PUNCT
gs-3446	54	17	and	and	CCONJ
gs-3446	54	18	standardization	standardization	NOUN
gs-3446	54	19	of	of	ADP
gs-3446	54	20	clinical	clinical	ADJ
gs-3446	54	21	protocols	protocol	NOUN
gs-3446	54	22	.	.	PUNCT
gs-3446	55	1	continued	continue	VERB
gs-3446	55	2	research	research	NOUN
gs-3446	55	3	and	and	CCONJ
gs-3446	55	4	technological	technological	ADJ
gs-3446	55	5	innovations	innovation	NOUN
gs-3446	55	6	are	be	AUX
gs-3446	55	7	essential	essential	ADJ
gs-3446	55	8	to	to	PART
gs-3446	55	9	harness	harness	VERB
gs-3446	55	10	the	the	DET
gs-3446	55	11	full	full	ADJ
gs-3446	55	12	potential	potential	NOUN
gs-3446	55	13	of	of	ADP
gs-3446	55	14	stem	stem	NOUN
gs-3446	55	15	cells	cell	NOUN
gs-3446	55	16	in	in	ADP
gs-3446	55	17	regenerative	regenerative	ADJ
gs-3446	55	18	medicine	medicine	NOUN
gs-3446	55	19	,	,	PUNCT
gs-3446	55	20	paving	pave	VERB
gs-3446	55	21	the	the	DET
gs-3446	55	22	way	way	NOUN
gs-3446	55	23	for	for	ADP
gs-3446	55	24	future	future	ADJ
gs-3446	55	25	therapeutic	therapeutic	ADJ
gs-3446	55	26	breakthroughs	breakthrough	NOUN
gs-3446	55	27	(	(	PUNCT
gs-3446	55	28	trounson	trounson	NOUN
gs-3446	55	29	et	et	PROPN
gs-3446	55	30	al	al	PROPN
gs-3446	55	31	.	.	PROPN
gs-3446	55	32	2015	2015	NUM
gs-3446	55	33	)	)	PUNCT
gs-3446	55	34	.	.	PUNCT
gs-3446	56	1	stem	stem	NOUN
gs-3446	56	2	cells	cell	NOUN
gs-3446	56	3	definitions	definition	NOUN
gs-3446	56	4	stem	stem	VERB
gs-3446	56	5	cells	cell	NOUN
gs-3446	56	6	are	be	AUX
gs-3446	56	7	the	the	DET
gs-3446	56	8	foundation	foundation	NOUN
gs-3446	56	9	of	of	ADP
gs-3446	56	10	biological	biological	ADJ
gs-3446	56	11	development	development	NOUN
gs-3446	56	12	and	and	CCONJ
gs-3446	56	13	tissue	tissue	NOUN
gs-3446	56	14	maintenance	maintenance	NOUN
gs-3446	56	15	,	,	PUNCT
gs-3446	56	16	possessing	possess	VERB
gs-3446	56	17	the	the	DET
gs-3446	56	18	remarkable	remarkable	ADJ
gs-3446	56	19	abilities	ability	NOUN
gs-3446	56	20	of	of	ADP
gs-3446	56	21	self	self	NOUN
gs-3446	56	22	-	-	PUNCT
gs-3446	56	23	renewal	renewal	NOUN
gs-3446	56	24	and	and	CCONJ
gs-3446	56	25	differentiation	differentiation	NOUN
gs-3446	56	26	.	.	PUNCT
gs-3446	57	1	these	these	DET
gs-3446	57	2	unique	unique	ADJ
gs-3446	57	3	properties	property	NOUN
gs-3446	57	4	enable	enable	VERB
gs-3446	57	5	them	they	PRON
gs-3446	57	6	to	to	PART
gs-3446	57	7	contribute	contribute	VERB
gs-3446	57	8	to	to	ADP
gs-3446	57	9	growth	growth	NOUN
gs-3446	57	10	,	,	PUNCT
gs-3446	57	11	repair	repair	NOUN
gs-3446	57	12	,	,	PUNCT
gs-3446	57	13	and	and	CCONJ
gs-3446	57	14	regeneration	regeneration	NOUN
gs-3446	57	15	throughout	throughout	ADP
gs-3446	57	16	an	an	DET
gs-3446	57	17	organism	organism	NOUN
gs-3446	57	18	's	's	PART
gs-3446	57	19	lifespan	lifespan	NOUN
gs-3446	57	20	.	.	PUNCT
gs-3446	58	1	stem	stem	NOUN
gs-3446	58	2	cell	cell	NOUN
gs-3446	58	3	systems	system	NOUN
gs-3446	58	4	exist	exist	VERB
gs-3446	58	5	in	in	ADP
gs-3446	58	6	both	both	CCONJ
gs-3446	58	7	embryonic	embryonic	ADJ
gs-3446	58	8	and	and	CCONJ
gs-3446	58	9	adult	adult	NOUN
gs-3446	58	10	tissues	tissue	NOUN
gs-3446	58	11	,	,	PUNCT
gs-3446	58	12	playing	play	VERB
gs-3446	58	13	crucial	crucial	ADJ
gs-3446	58	14	roles	role	NOUN
gs-3446	58	15	in	in	ADP
gs-3446	58	16	maintaining	maintain	VERB
gs-3446	58	17	cellular	cellular	ADJ
gs-3446	58	18	homeostasis	homeostasis	NOUN
gs-3446	58	19	and	and	CCONJ
gs-3446	58	20	responding	respond	VERB
gs-3446	58	21	to	to	ADP
gs-3446	58	22	injury	injury	NOUN
gs-3446	58	23	.	.	PUNCT
gs-3446	59	1	understanding	understand	VERB
gs-3446	59	2	the	the	DET
gs-3446	59	3	mechanisms	mechanism	NOUN
gs-3446	59	4	governing	govern	VERB
gs-3446	59	5	stem	stem	NOUN
gs-3446	59	6	cell	cell	NOUN
gs-3446	59	7	function	function	NOUN
gs-3446	59	8	is	be	AUX
gs-3446	59	9	essential	essential	ADJ
gs-3446	59	10	for	for	ADP
gs-3446	59	11	advancing	advance	VERB
gs-3446	59	12	regenerative	regenerative	ADJ
gs-3446	59	13	medicine	medicine	NOUN
gs-3446	59	14	,	,	PUNCT
gs-3446	59	15	where	where	SCONJ
gs-3446	59	16	damaged	damage	VERB
gs-3446	59	17	or	or	CCONJ
gs-3446	59	18	diseased	diseased	ADJ
gs-3446	59	19	tissues	tissue	NOUN
gs-3446	59	20	can	can	AUX
gs-3446	59	21	be	be	AUX
gs-3446	59	22	restored	restore	VERB
gs-3446	59	23	using	use	VERB
gs-3446	59	24	stem	stem	NOUN
gs-3446	59	25	cellbased	cellbase	VERB
gs-3446	59	26	therapies	therapy	NOUN
gs-3446	59	27	.	.	PUNCT
gs-3446	60	1	in	in	ADP
gs-3446	60	2	recent	recent	ADJ
gs-3446	60	3	years	year	NOUN
gs-3446	60	4	,	,	PUNCT
gs-3446	60	5	significant	significant	ADJ
gs-3446	60	6	progress	progress	NOUN
gs-3446	60	7	has	have	AUX
gs-3446	60	8	been	be	AUX
gs-3446	60	9	made	make	VERB
gs-3446	60	10	in	in	ADP
gs-3446	60	11	elucidating	elucidate	VERB
gs-3446	60	12	the	the	DET
gs-3446	60	13	molecular	molecular	ADJ
gs-3446	60	14	and	and	CCONJ
gs-3446	60	15	cellular	cellular	ADJ
gs-3446	60	16	mechanisms	mechanism	NOUN
gs-3446	60	17	that	that	PRON
gs-3446	60	18	regulate	regulate	VERB
gs-3446	60	19	stem	stem	NOUN
gs-3446	60	20	cell	cell	NOUN
gs-3446	60	21	behavior	behavior	NOUN
gs-3446	60	22	.	.	PUNCT
gs-3446	61	1	various	various	ADJ
gs-3446	61	2	signaling	signal	VERB
gs-3446	61	3	pathways	pathway	NOUN
gs-3446	61	4	,	,	PUNCT
gs-3446	61	5	including	include	VERB
gs-3446	61	6	wnt	wnt	PROPN
gs-3446	61	7	,	,	PUNCT
gs-3446	61	8	notch	notch	NOUN
gs-3446	61	9	,	,	PUNCT
gs-3446	61	10	and	and	CCONJ
gs-3446	61	11	hedgehog	hedgehog	NOUN
gs-3446	61	12	,	,	PUNCT
gs-3446	61	13	have	have	AUX
gs-3446	61	14	been	be	AUX
gs-3446	61	15	identified	identify	VERB
gs-3446	61	16	as	as	ADP
gs-3446	61	17	critical	critical	ADJ
gs-3446	61	18	regulators	regulator	NOUN
gs-3446	61	19	of	of	ADP
gs-3446	61	20	stem	stem	NOUN
gs-3446	61	21	cell	cell	NOUN
gs-3446	61	22	fate	fate	NOUN
gs-3446	61	23	,	,	PUNCT
gs-3446	61	24	influencing	influence	VERB
gs-3446	61	25	their	their	PRON
gs-3446	61	26	ability	ability	NOUN
gs-3446	61	27	to	to	PART
gs-3446	61	28	divide	divide	VERB
gs-3446	61	29	and	and	CCONJ
gs-3446	61	30	differentiate	differentiate	VERB
gs-3446	61	31	into	into	ADP
gs-3446	61	32	specialized	specialized	ADJ
gs-3446	61	33	cell	cell	NOUN
gs-3446	61	34	types	type	NOUN
gs-3446	61	35	.	.	PUNCT
gs-3446	62	1	additionally	additionally	ADV
gs-3446	62	2	,	,	PUNCT
gs-3446	62	3	the	the	DET
gs-3446	62	4	microenvironment	microenvironment	NOUN
gs-3446	62	5	,	,	PUNCT
gs-3446	62	6	or	or	CCONJ
gs-3446	62	7	niche	niche	NOUN
gs-3446	62	8	,	,	PUNCT
gs-3446	62	9	in	in	ADP
gs-3446	62	10	which	which	PRON
gs-3446	62	11	georgian	georgian	PROPN
gs-3446	62	12	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3446	62	13	მეცნიერები	მეცნიერები	NOUN
gs-3446	62	14	ტ.	ტ.	VERB
gs-3446	62	15	7	7	NUM
gs-3446	62	16	n	n	PRON
gs-3446	62	17	1	1	NUM
gs-3446	62	18	,	,	PUNCT
gs-3446	62	19	2025	2025	NUM
gs-3446	62	20	275	275	NUM
gs-3446	62	21	stem	stem	NOUN
gs-3446	62	22	cells	cell	NOUN
gs-3446	62	23	reside	reside	VERB
gs-3446	62	24	plays	play	VERB
gs-3446	62	25	a	a	DET
gs-3446	62	26	pivotal	pivotal	ADJ
gs-3446	62	27	role	role	NOUN
gs-3446	62	28	in	in	ADP
gs-3446	62	29	modulating	modulate	VERB
gs-3446	62	30	their	their	PRON
gs-3446	62	31	function	function	NOUN
gs-3446	62	32	,	,	PUNCT
gs-3446	62	33	ensuring	ensure	VERB
gs-3446	62	34	a	a	DET
gs-3446	62	35	balance	balance	NOUN
gs-3446	62	36	between	between	ADP
gs-3446	62	37	selfrenewal	selfrenewal	NOUN
gs-3446	62	38	and	and	CCONJ
gs-3446	62	39	differentiation	differentiation	NOUN
gs-3446	62	40	.	.	PUNCT
gs-3446	63	1	stem	stem	NOUN
gs-3446	63	2	cell	cell	NOUN
gs-3446	63	3	-	-	PUNCT
gs-3446	63	4	based	base	VERB
gs-3446	63	5	therapies	therapy	NOUN
gs-3446	63	6	are	be	AUX
gs-3446	63	7	being	be	AUX
gs-3446	63	8	explored	explore	VERB
gs-3446	63	9	for	for	ADP
gs-3446	63	10	treating	treat	VERB
gs-3446	63	11	a	a	DET
gs-3446	63	12	wide	wide	ADJ
gs-3446	63	13	range	range	NOUN
gs-3446	63	14	of	of	ADP
gs-3446	63	15	conditions	condition	NOUN
gs-3446	63	16	,	,	PUNCT
gs-3446	63	17	including	include	VERB
gs-3446	63	18	neurodegenerative	neurodegenerative	ADJ
gs-3446	63	19	disorders	disorder	NOUN
gs-3446	63	20	,	,	PUNCT
gs-3446	63	21	cardiovascular	cardiovascular	ADJ
gs-3446	63	22	diseases	disease	NOUN
gs-3446	63	23	,	,	PUNCT
gs-3446	63	24	and	and	CCONJ
gs-3446	63	25	musculoskeletal	musculoskeletal	ADJ
gs-3446	63	26	injuries	injury	NOUN
gs-3446	63	27	.	.	PUNCT
gs-3446	64	1	induced	induce	VERB
gs-3446	64	2	pluripotent	pluripotent	ADJ
gs-3446	64	3	stem	stem	NOUN
gs-3446	64	4	cells	cell	NOUN
gs-3446	64	5	(	(	PUNCT
gs-3446	64	6	ipscs	ipscs	NOUN
gs-3446	64	7	)	)	PUNCT
gs-3446	64	8	,	,	PUNCT
gs-3446	64	9	derived	derive	VERB
gs-3446	64	10	from	from	ADP
gs-3446	64	11	reprogrammed	reprogrammed	ADJ
gs-3446	64	12	adult	adult	NOUN
gs-3446	64	13	cells	cell	NOUN
gs-3446	64	14	,	,	PUNCT
gs-3446	64	15	have	have	AUX
gs-3446	64	16	revolutionized	revolutionize	VERB
gs-3446	64	17	the	the	DET
gs-3446	64	18	field	field	NOUN
gs-3446	64	19	by	by	ADP
gs-3446	64	20	providing	provide	VERB
gs-3446	64	21	patient	patient	NOUN
gs-3446	64	22	-	-	PUNCT
gs-3446	64	23	specific	specific	ADJ
gs-3446	64	24	cells	cell	NOUN
gs-3446	64	25	for	for	ADP
gs-3446	64	26	personalized	personalized	ADJ
gs-3446	64	27	medicine	medicine	NOUN
gs-3446	64	28	.	.	PUNCT
gs-3446	65	1	meanwhile	meanwhile	ADV
gs-3446	65	2	,	,	PUNCT
gs-3446	65	3	advances	advance	NOUN
gs-3446	65	4	in	in	ADP
gs-3446	65	5	tissue	tissue	NOUN
gs-3446	65	6	engineering	engineering	NOUN
gs-3446	65	7	and	and	CCONJ
gs-3446	65	8	biomaterials	biomaterial	NOUN
gs-3446	65	9	are	be	AUX
gs-3446	65	10	enhancing	enhance	VERB
gs-3446	65	11	the	the	DET
gs-3446	65	12	effectiveness	effectiveness	NOUN
gs-3446	65	13	of	of	ADP
gs-3446	65	14	stem	stem	NOUN
gs-3446	65	15	cell	cell	NOUN
gs-3446	65	16	transplantation	transplantation	NOUN
gs-3446	65	17	by	by	ADP
gs-3446	65	18	creating	create	VERB
gs-3446	65	19	optimal	optimal	ADJ
gs-3446	65	20	conditions	condition	NOUN
gs-3446	65	21	for	for	ADP
gs-3446	65	22	cell	cell	NOUN
gs-3446	65	23	survival	survival	NOUN
gs-3446	65	24	and	and	CCONJ
gs-3446	65	25	integration	integration	NOUN
gs-3446	65	26	(	(	PUNCT
gs-3446	65	27	singh	singh	PROPN
gs-3446	65	28	et	et	PROPN
gs-3446	65	29	al	al	PROPN
gs-3446	65	30	.	.	PROPN
gs-3446	65	31	2015	2015	NUM
gs-3446	65	32	)	)	PUNCT
gs-3446	65	33	.	.	PUNCT
gs-3446	66	1	figure	figure	NOUN
gs-3446	66	2	1	1	NUM
gs-3446	66	3	.	.	PUNCT
gs-3446	67	1	generation	generation	NOUN
gs-3446	67	2	of	of	ADP
gs-3446	67	3	pluripotent	pluripotent	ADJ
gs-3446	67	4	cells	cell	NOUN
gs-3446	67	5	from	from	ADP
gs-3446	67	6	blastocysts	blastocyst	NOUN
gs-3446	67	7	and	and	CCONJ
gs-3446	67	8	their	their	PRON
gs-3446	67	9	differentiation	differentiation	NOUN
gs-3446	67	10	into	into	ADP
gs-3446	67	11	specialized	specialized	ADJ
gs-3446	67	12	cell	cell	NOUN
gs-3446	67	13	types	type	NOUN
gs-3446	67	14	.	.	PUNCT
gs-3446	68	1	the	the	DET
gs-3446	68	2	figure	figure	NOUN
gs-3446	68	3	illustrates	illustrate	VERB
gs-3446	68	4	the	the	DET
gs-3446	68	5	derivation	derivation	NOUN
gs-3446	68	6	of	of	ADP
gs-3446	68	7	pluripotent	pluripotent	ADJ
gs-3446	68	8	stem	stem	NOUN
gs-3446	68	9	cells	cell	NOUN
gs-3446	68	10	from	from	ADP
gs-3446	68	11	the	the	DET
gs-3446	68	12	inner	inner	ADJ
gs-3446	68	13	cell	cell	NOUN
gs-3446	68	14	mass	mass	NOUN
gs-3446	68	15	of	of	ADP
gs-3446	68	16	a	a	DET
gs-3446	68	17	blastocyst	blastocyst	NOUN
gs-3446	68	18	and	and	CCONJ
gs-3446	68	19	their	their	PRON
gs-3446	68	20	subsequent	subsequent	ADJ
gs-3446	68	21	differentiation	differentiation	NOUN
gs-3446	68	22	into	into	ADP
gs-3446	68	23	nerve	nerve	NOUN
gs-3446	68	24	cells	cell	NOUN
gs-3446	68	25	(	(	PUNCT
gs-3446	68	26	ectoderm	ectoderm	NOUN
gs-3446	68	27	)	)	PUNCT
gs-3446	68	28	,	,	PUNCT
gs-3446	68	29	liver	liver	NOUN
gs-3446	68	30	cells	cell	NOUN
gs-3446	68	31	(	(	PUNCT
gs-3446	68	32	endoderm	endoderm	NOUN
gs-3446	68	33	)	)	PUNCT
gs-3446	68	34	,	,	PUNCT
gs-3446	68	35	and	and	CCONJ
gs-3446	68	36	cardiac	cardiac	ADJ
gs-3446	68	37	and	and	CCONJ
gs-3446	68	38	blood	blood	NOUN
gs-3446	68	39	cells	cell	NOUN
gs-3446	68	40	(	(	PUNCT
gs-3446	68	41	mesoderm	mesoderm	NOUN
gs-3446	68	42	)	)	PUNCT
gs-3446	68	43	.	.	PUNCT
gs-3446	69	1	this	this	DET
gs-3446	69	2	process	process	NOUN
gs-3446	69	3	highlights	highlight	VERB
gs-3446	69	4	the	the	DET
gs-3446	69	5	potential	potential	NOUN
gs-3446	69	6	of	of	ADP
gs-3446	69	7	pluripotent	pluripotent	ADJ
gs-3446	69	8	stem	stem	NOUN
gs-3446	69	9	cells	cell	NOUN
gs-3446	69	10	for	for	ADP
gs-3446	69	11	regenerative	regenerative	ADJ
gs-3446	69	12	medicine	medicine	NOUN
gs-3446	69	13	and	and	CCONJ
gs-3446	69	14	tissue	tissue	NOUN
gs-3446	69	15	engineering	engineering	NOUN
gs-3446	69	16	.	.	PUNCT
gs-3446	70	1	despite	despite	SCONJ
gs-3446	70	2	the	the	DET
gs-3446	70	3	vast	vast	ADJ
gs-3446	70	4	potential	potential	NOUN
gs-3446	70	5	of	of	ADP
gs-3446	70	6	stem	stem	NOUN
gs-3446	70	7	cell	cell	NOUN
gs-3446	70	8	therapies	therapy	NOUN
gs-3446	70	9	,	,	PUNCT
gs-3446	70	10	several	several	ADJ
gs-3446	70	11	challenges	challenge	NOUN
gs-3446	70	12	remain	remain	VERB
gs-3446	70	13	,	,	PUNCT
gs-3446	70	14	including	include	VERB
gs-3446	70	15	immune	immune	ADJ
gs-3446	70	16	rejection	rejection	NOUN
gs-3446	70	17	,	,	PUNCT
gs-3446	70	18	ethical	ethical	ADJ
gs-3446	70	19	concerns	concern	NOUN
gs-3446	70	20	,	,	PUNCT
gs-3446	70	21	and	and	CCONJ
gs-3446	70	22	the	the	DET
gs-3446	70	23	risk	risk	NOUN
gs-3446	70	24	of	of	ADP
gs-3446	70	25	uncontrolled	uncontrolled	ADJ
gs-3446	70	26	cell	cell	NOUN
gs-3446	70	27	growth	growth	NOUN
gs-3446	70	28	.	.	PUNCT
gs-3446	71	1	ongoing	ongoing	ADJ
gs-3446	71	2	research	research	NOUN
gs-3446	71	3	aims	aim	VERB
gs-3446	71	4	to	to	PART
gs-3446	71	5	overcome	overcome	VERB
gs-3446	71	6	these	these	DET
gs-3446	71	7	hurdles	hurdle	NOUN
gs-3446	71	8	by	by	ADP
gs-3446	71	9	refining	refine	VERB
gs-3446	71	10	differentiation	differentiation	NOUN
gs-3446	71	11	protocols	protocol	NOUN
gs-3446	71	12	,	,	PUNCT
gs-3446	71	13	improving	improve	VERB
gs-3446	71	14	delivery	delivery	NOUN
gs-3446	71	15	methods	method	NOUN
gs-3446	71	16	,	,	PUNCT
gs-3446	71	17	and	and	CCONJ
gs-3446	71	18	ensuring	ensure	VERB
gs-3446	71	19	the	the	DET
gs-3446	71	20	safety	safety	NOUN
gs-3446	71	21	and	and	CCONJ
gs-3446	71	22	efficacy	efficacy	NOUN
gs-3446	71	23	of	of	ADP
gs-3446	71	24	stem	stem	NOUN
gs-3446	71	25	cell	cell	NOUN
gs-3446	71	26	applications	application	NOUN
gs-3446	71	27	.	.	PUNCT
gs-3446	72	1	as	as	SCONJ
gs-3446	72	2	our	our	PRON
gs-3446	72	3	understanding	understanding	NOUN
gs-3446	72	4	of	of	ADP
gs-3446	72	5	stem	stem	NOUN
gs-3446	72	6	cell	cell	NOUN
gs-3446	72	7	systems	system	NOUN
gs-3446	72	8	deepens	deepen	VERB
gs-3446	72	9	,	,	PUNCT
gs-3446	72	10	the	the	DET
gs-3446	72	11	prospect	prospect	NOUN
gs-3446	72	12	of	of	ADP
gs-3446	72	13	harnessing	harness	VERB
gs-3446	72	14	their	their	PRON
gs-3446	72	15	regenerative	regenerative	ADJ
gs-3446	72	16	capabilities	capability	NOUN
gs-3446	72	17	for	for	ADP
gs-3446	72	18	clinical	clinical	ADJ
gs-3446	72	19	applications	application	NOUN
gs-3446	72	20	becomes	become	VERB
gs-3446	72	21	increasingly	increasingly	ADV
gs-3446	72	22	viable	viable	ADJ
gs-3446	72	23	,	,	PUNCT
gs-3446	72	24	paving	pave	VERB
gs-3446	72	25	the	the	DET
gs-3446	72	26	way	way	NOUN
gs-3446	72	27	for	for	ADP
gs-3446	72	28	transformative	transformative	ADJ
gs-3446	72	29	advancements	advancement	NOUN
gs-3446	72	30	in	in	ADP
gs-3446	72	31	medicine	medicine	NOUN
gs-3446	72	32	and	and	CCONJ
gs-3446	72	33	biotechnology	biotechnology	NOUN
gs-3446	72	34	(	(	PUNCT
gs-3446	72	35	halpern	halpern	PROPN
gs-3446	72	36	et	et	PROPN
gs-3446	72	37	al	al	PROPN
gs-3446	72	38	.	.	PROPN
gs-3446	72	39	2019	2019	NUM
gs-3446	72	40	)	)	PUNCT
gs-3446	72	41	.	.	PUNCT
gs-3446	73	1	georgian	georgian	ADJ
gs-3446	73	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	73	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	73	4	ტ.	ტ.	VERB
gs-3446	73	5	7	7	NUM
gs-3446	73	6	n	n	PRON
gs-3446	73	7	1	1	NUM
gs-3446	73	8	,	,	PUNCT
gs-3446	73	9	2025	2025	NUM
gs-3446	73	10	276	276	NUM
gs-3446	73	11	characteristics	characteristic	NOUN
gs-3446	73	12	of	of	ADP
gs-3446	73	13	stem	stem	NOUN
gs-3446	73	14	cells	cell	NOUN
gs-3446	73	15	stem	stem	VERB
gs-3446	73	16	cells	cell	NOUN
gs-3446	73	17	are	be	AUX
gs-3446	73	18	undifferentiated	undifferentiated	ADJ
gs-3446	73	19	cells	cell	NOUN
gs-3446	73	20	with	with	ADP
gs-3446	73	21	the	the	DET
gs-3446	73	22	ability	ability	NOUN
gs-3446	73	23	to	to	PART
gs-3446	73	24	self	self	NOUN
gs-3446	73	25	-	-	PUNCT
gs-3446	73	26	renew	renew	VERB
gs-3446	73	27	and	and	CCONJ
gs-3446	73	28	differentiate	differentiate	VERB
gs-3446	73	29	into	into	ADP
gs-3446	73	30	specialized	specialized	ADJ
gs-3446	73	31	cell	cell	NOUN
gs-3446	73	32	types	type	NOUN
gs-3446	73	33	.	.	PUNCT
gs-3446	74	1	they	they	PRON
gs-3446	74	2	serve	serve	VERB
gs-3446	74	3	as	as	ADP
gs-3446	74	4	the	the	DET
gs-3446	74	5	building	building	NOUN
gs-3446	74	6	blocks	block	NOUN
gs-3446	74	7	of	of	ADP
gs-3446	74	8	growth	growth	NOUN
gs-3446	74	9	and	and	CCONJ
gs-3446	74	10	tissue	tissue	NOUN
gs-3446	74	11	maintenance	maintenance	NOUN
gs-3446	74	12	in	in	ADP
gs-3446	74	13	multicellular	multicellular	ADJ
gs-3446	74	14	organisms	organism	NOUN
gs-3446	74	15	.	.	PUNCT
gs-3446	75	1	based	base	VERB
gs-3446	75	2	on	on	ADP
gs-3446	75	3	their	their	PRON
gs-3446	75	4	potency	potency	NOUN
gs-3446	75	5	and	and	CCONJ
gs-3446	75	6	origin	origin	NOUN
gs-3446	75	7	,	,	PUNCT
gs-3446	75	8	stem	stem	NOUN
gs-3446	75	9	cells	cell	NOUN
gs-3446	75	10	are	be	AUX
gs-3446	75	11	broadly	broadly	ADV
gs-3446	75	12	classified	classify	VERB
gs-3446	75	13	into	into	ADP
gs-3446	75	14	embryonic	embryonic	ADJ
gs-3446	75	15	stem	stem	NOUN
gs-3446	75	16	cells	cell	NOUN
gs-3446	75	17	(	(	PUNCT
gs-3446	75	18	escs	esc	NOUN
gs-3446	75	19	)	)	PUNCT
gs-3446	75	20	,	,	PUNCT
gs-3446	75	21	adult	adult	NOUN
gs-3446	75	22	stem	stem	NOUN
gs-3446	75	23	cells	cell	NOUN
gs-3446	75	24	(	(	PUNCT
gs-3446	75	25	ascs	asc	NOUN
gs-3446	75	26	)	)	PUNCT
gs-3446	75	27	,	,	PUNCT
gs-3446	75	28	and	and	CCONJ
gs-3446	75	29	induced	induce	VERB
gs-3446	75	30	pluripotent	pluripotent	ADJ
gs-3446	75	31	stem	stem	NOUN
gs-3446	75	32	cells	cell	NOUN
gs-3446	75	33	(	(	PUNCT
gs-3446	75	34	ipscs	ipscs	NOUN
gs-3446	75	35	)	)	PUNCT
gs-3446	75	36	.	.	PUNCT
gs-3446	76	1	these	these	DET
gs-3446	76	2	cells	cell	NOUN
gs-3446	76	3	play	play	VERB
gs-3446	76	4	a	a	DET
gs-3446	76	5	crucial	crucial	ADJ
gs-3446	76	6	role	role	NOUN
gs-3446	76	7	in	in	ADP
gs-3446	76	8	both	both	PRON
gs-3446	76	9	developmental	developmental	ADJ
gs-3446	76	10	biology	biology	NOUN
gs-3446	76	11	and	and	CCONJ
gs-3446	76	12	regenerative	regenerative	ADJ
gs-3446	76	13	medicine	medicine	NOUN
gs-3446	76	14	,	,	PUNCT
gs-3446	76	15	offering	offer	VERB
gs-3446	76	16	potential	potential	ADJ
gs-3446	76	17	therapeutic	therapeutic	ADJ
gs-3446	76	18	solutions	solution	NOUN
gs-3446	76	19	for	for	ADP
gs-3446	76	20	various	various	ADJ
gs-3446	76	21	degenerative	degenerative	NOUN
gs-3446	76	22	and	and	CCONJ
gs-3446	76	23	injury	injury	NOUN
gs-3446	76	24	-	-	PUNCT
gs-3446	76	25	related	relate	VERB
gs-3446	76	26	conditions	condition	NOUN
gs-3446	76	27	(	(	PUNCT
gs-3446	76	28	singh	singh	PROPN
gs-3446	76	29	et	et	PROPN
gs-3446	76	30	al	al	PROPN
gs-3446	76	31	.	.	PROPN
gs-3446	76	32	2015	2015	NUM
gs-3446	76	33	)	)	PUNCT
gs-3446	76	34	.	.	PUNCT
gs-3446	77	1	types	type	NOUN
gs-3446	77	2	of	of	ADP
gs-3446	77	3	stem	stem	NOUN
gs-3446	77	4	cells	cell	NOUN
gs-3446	77	5	and	and	CCONJ
gs-3446	77	6	their	their	PRON
gs-3446	77	7	characteristics	characteristic	NOUN
gs-3446	77	8	stem	stem	NOUN
gs-3446	77	9	cells	cell	NOUN
gs-3446	77	10	can	can	AUX
gs-3446	77	11	be	be	AUX
gs-3446	77	12	categorized	categorize	VERB
gs-3446	77	13	based	base	VERB
gs-3446	77	14	on	on	ADP
gs-3446	77	15	their	their	PRON
gs-3446	77	16	differentiation	differentiation	NOUN
gs-3446	77	17	potential	potential	NOUN
gs-3446	77	18	:	:	PUNCT
gs-3446	77	19	●	●	PUNCT
gs-3446	77	20	totipotent	totipotent	ADJ
gs-3446	77	21	stem	stem	NOUN
gs-3446	77	22	cells	cell	NOUN
gs-3446	77	23	:	:	PUNCT
gs-3446	77	24	these	these	DET
gs-3446	77	25	cells	cell	NOUN
gs-3446	77	26	,	,	PUNCT
gs-3446	77	27	such	such	ADJ
gs-3446	77	28	as	as	ADP
gs-3446	77	29	the	the	DET
gs-3446	77	30	zygote	zygote	NOUN
gs-3446	77	31	,	,	PUNCT
gs-3446	77	32	have	have	VERB
gs-3446	77	33	the	the	DET
gs-3446	77	34	ability	ability	NOUN
gs-3446	77	35	to	to	PART
gs-3446	77	36	differentiate	differentiate	VERB
gs-3446	77	37	into	into	ADP
gs-3446	77	38	any	any	DET
gs-3446	77	39	cell	cell	NOUN
gs-3446	77	40	type	type	NOUN
gs-3446	77	41	,	,	PUNCT
gs-3446	77	42	including	include	VERB
gs-3446	77	43	extraembryonic	extraembryonic	ADJ
gs-3446	77	44	tissues	tissue	NOUN
gs-3446	77	45	like	like	ADP
gs-3446	77	46	the	the	DET
gs-3446	77	47	placenta	placenta	NOUN
gs-3446	77	48	.	.	PUNCT
gs-3446	78	1	●	●	PUNCT
gs-3446	78	2	pluripotent	pluripotent	ADJ
gs-3446	78	3	stem	stem	NOUN
gs-3446	78	4	cells	cell	NOUN
gs-3446	78	5	:	:	PUNCT
gs-3446	78	6	embryonic	embryonic	ADJ
gs-3446	78	7	stem	stem	NOUN
gs-3446	78	8	cells	cell	NOUN
gs-3446	78	9	fall	fall	VERB
gs-3446	78	10	into	into	ADP
gs-3446	78	11	this	this	DET
gs-3446	78	12	category	category	NOUN
gs-3446	78	13	and	and	CCONJ
gs-3446	78	14	can	can	AUX
gs-3446	78	15	give	give	VERB
gs-3446	78	16	rise	rise	NOUN
gs-3446	78	17	to	to	ADP
gs-3446	78	18	all	all	DET
gs-3446	78	19	three	three	NUM
gs-3446	78	20	germ	germ	NOUN
gs-3446	78	21	layers	layer	NOUN
gs-3446	78	22	(	(	PUNCT
gs-3446	78	23	ectoderm	ectoderm	NOUN
gs-3446	78	24	,	,	PUNCT
gs-3446	78	25	mesoderm	mesoderm	NOUN
gs-3446	78	26	,	,	PUNCT
gs-3446	78	27	and	and	CCONJ
gs-3446	78	28	endoderm	endoderm	NOUN
gs-3446	78	29	)	)	PUNCT
gs-3446	78	30	but	but	CCONJ
gs-3446	78	31	not	not	PART
gs-3446	78	32	extraembryonic	extraembryonic	ADJ
gs-3446	78	33	tissues	tissue	NOUN
gs-3446	78	34	.	.	PUNCT
gs-3446	79	1	●	●	PUNCT
gs-3446	79	2	multipotent	multipotent	NOUN
gs-3446	79	3	stem	stem	NOUN
gs-3446	79	4	cells	cell	NOUN
gs-3446	79	5	:	:	PUNCT
gs-3446	79	6	found	find	VERB
gs-3446	79	7	in	in	ADP
gs-3446	79	8	adult	adult	NOUN
gs-3446	79	9	tissues	tissue	NOUN
gs-3446	79	10	,	,	PUNCT
gs-3446	79	11	these	these	DET
gs-3446	79	12	cells	cell	NOUN
gs-3446	79	13	have	have	VERB
gs-3446	79	14	a	a	DET
gs-3446	79	15	more	more	ADV
gs-3446	79	16	restricted	restricted	ADJ
gs-3446	79	17	differentiation	differentiation	NOUN
gs-3446	79	18	potential	potential	NOUN
gs-3446	79	19	and	and	CCONJ
gs-3446	79	20	can	can	AUX
gs-3446	79	21	generate	generate	VERB
gs-3446	79	22	specific	specific	ADJ
gs-3446	79	23	cell	cell	NOUN
gs-3446	79	24	lineages	lineage	NOUN
gs-3446	79	25	(	(	PUNCT
gs-3446	79	26	e.g.	e.g.	ADV
gs-3446	79	27	,	,	PUNCT
gs-3446	79	28	hematopoietic	hematopoietic	ADJ
gs-3446	79	29	stem	stem	NOUN
gs-3446	79	30	cells	cell	NOUN
gs-3446	79	31	can	can	AUX
gs-3446	79	32	differentiate	differentiate	VERB
gs-3446	79	33	into	into	ADP
gs-3446	79	34	various	various	ADJ
gs-3446	79	35	blood	blood	NOUN
gs-3446	79	36	cells	cell	NOUN
gs-3446	79	37	)	)	PUNCT
gs-3446	79	38	.	.	PUNCT
gs-3446	80	1	●	●	PUNCT
gs-3446	80	2	unipotent	unipotent	ADJ
gs-3446	80	3	stem	stem	NOUN
gs-3446	80	4	cells	cell	NOUN
gs-3446	80	5	:	:	PUNCT
gs-3446	80	6	these	these	DET
gs-3446	80	7	cells	cell	NOUN
gs-3446	80	8	are	be	AUX
gs-3446	80	9	lineage	lineage	NOUN
gs-3446	80	10	-	-	PUNCT
gs-3446	80	11	restricted	restrict	VERB
gs-3446	80	12	and	and	CCONJ
gs-3446	80	13	can	can	AUX
gs-3446	80	14	only	only	ADV
gs-3446	80	15	generate	generate	VERB
gs-3446	80	16	one	one	NUM
gs-3446	80	17	type	type	NOUN
gs-3446	80	18	of	of	ADP
gs-3446	80	19	specialized	specialized	ADJ
gs-3446	80	20	cell	cell	NOUN
gs-3446	80	21	(	(	PUNCT
gs-3446	80	22	e.g.	e.g.	ADV
gs-3446	80	23	,	,	PUNCT
gs-3446	80	24	muscle	muscle	NOUN
gs-3446	80	25	stem	stem	NOUN
gs-3446	80	26	cells	cell	NOUN
gs-3446	80	27	forming	form	VERB
gs-3446	80	28	muscle	muscle	NOUN
gs-3446	80	29	fibers	fiber	NOUN
gs-3446	80	30	)	)	PUNCT
gs-3446	80	31	.	.	PUNCT
gs-3446	81	1	●	●	PUNCT
gs-3446	81	2	induced	induce	VERB
gs-3446	81	3	pluripotent	pluripotent	ADJ
gs-3446	81	4	stem	stem	NOUN
gs-3446	81	5	cells	cell	NOUN
gs-3446	81	6	(	(	PUNCT
gs-3446	81	7	ipscs	ipsc	NOUN
gs-3446	81	8	):	):	PUNCT
gs-3446	81	9	these	these	PRON
gs-3446	81	10	are	be	AUX
gs-3446	81	11	reprogrammed	reprogramme	VERB
gs-3446	81	12	adult	adult	NOUN
gs-3446	81	13	cells	cell	NOUN
gs-3446	81	14	that	that	PRON
gs-3446	81	15	have	have	AUX
gs-3446	81	16	been	be	AUX
gs-3446	81	17	genetically	genetically	ADV
gs-3446	81	18	modified	modify	VERB
gs-3446	81	19	to	to	PART
gs-3446	81	20	regain	regain	VERB
gs-3446	81	21	pluripotency	pluripotency	NOUN
gs-3446	81	22	,	,	PUNCT
gs-3446	81	23	offering	offer	VERB
gs-3446	81	24	significant	significant	ADJ
gs-3446	81	25	potential	potential	NOUN
gs-3446	81	26	for	for	ADP
gs-3446	81	27	personalized	personalized	ADJ
gs-3446	81	28	medicine	medicine	NOUN
gs-3446	81	29	(	(	PUNCT
gs-3446	81	30	aphkhazava	aphkhazava	NOUN
gs-3446	81	31	et	et	PROPN
gs-3446	81	32	al	al	PROPN
gs-3446	81	33	.	.	PROPN
gs-3446	81	34	2023	2023	NUM
gs-3446	81	35	)	)	PUNCT
gs-3446	81	36	.	.	PUNCT
gs-3446	82	1	stem	stem	NOUN
gs-3446	82	2	cell	cell	NOUN
gs-3446	82	3	niches	niche	NOUN
gs-3446	82	4	and	and	CCONJ
gs-3446	82	5	regulation	regulation	NOUN
gs-3446	82	6	stem	stem	NOUN
gs-3446	82	7	cells	cell	NOUN
gs-3446	82	8	reside	reside	VERB
gs-3446	82	9	in	in	ADP
gs-3446	82	10	specialized	specialized	ADJ
gs-3446	82	11	microenvironments	microenvironment	NOUN
gs-3446	82	12	called	call	VERB
gs-3446	82	13	niches	niche	NOUN
gs-3446	82	14	,	,	PUNCT
gs-3446	82	15	which	which	PRON
gs-3446	82	16	regulate	regulate	VERB
gs-3446	82	17	their	their	PRON
gs-3446	82	18	function	function	NOUN
gs-3446	82	19	through	through	ADP
gs-3446	82	20	intrinsic	intrinsic	ADJ
gs-3446	82	21	and	and	CCONJ
gs-3446	82	22	extrinsic	extrinsic	ADJ
gs-3446	82	23	signaling	signal	VERB
gs-3446	82	24	.	.	PUNCT
gs-3446	83	1	the	the	DET
gs-3446	83	2	niche	niche	NOUN
gs-3446	83	3	provides	provide	VERB
gs-3446	83	4	necessary	necessary	ADJ
gs-3446	83	5	factors	factor	NOUN
gs-3446	83	6	to	to	PART
gs-3446	83	7	maintain	maintain	VERB
gs-3446	83	8	stem	stem	NOUN
gs-3446	83	9	cell	cell	NOUN
gs-3446	83	10	quiescence	quiescence	NOUN
gs-3446	83	11	,	,	PUNCT
gs-3446	83	12	self	self	NOUN
gs-3446	83	13	-	-	PUNCT
gs-3446	83	14	renewal	renewal	NOUN
gs-3446	83	15	,	,	PUNCT
gs-3446	83	16	or	or	CCONJ
gs-3446	83	17	differentiation	differentiation	NOUN
gs-3446	83	18	in	in	ADP
gs-3446	83	19	response	response	NOUN
gs-3446	83	20	to	to	ADP
gs-3446	83	21	physiological	physiological	ADJ
gs-3446	83	22	needs	need	NOUN
gs-3446	83	23	.	.	PUNCT
gs-3446	84	1	key	key	ADJ
gs-3446	84	2	regulatory	regulatory	ADJ
gs-3446	84	3	pathways	pathway	NOUN
gs-3446	84	4	include	include	VERB
gs-3446	84	5	:	:	PUNCT
gs-3446	84	6	●	●	NUM
gs-3446	84	7	wnt	wnt	NOUN
gs-3446	84	8	signaling	signal	VERB
gs-3446	84	9	:	:	PUNCT
gs-3446	84	10	crucial	crucial	ADJ
gs-3446	84	11	for	for	ADP
gs-3446	84	12	maintaining	maintain	VERB
gs-3446	84	13	stem	stem	NOUN
gs-3446	84	14	cell	cell	NOUN
gs-3446	84	15	self	self	NOUN
gs-3446	84	16	-	-	PUNCT
gs-3446	84	17	renewal	renewal	NOUN
gs-3446	84	18	and	and	CCONJ
gs-3446	84	19	tissue	tissue	NOUN
gs-3446	84	20	homeostasis	homeostasis	NOUN
gs-3446	84	21	.	.	PUNCT
gs-3446	85	1	●	●	PUNCT
gs-3446	85	2	notch	notch	ADJ
gs-3446	85	3	signaling	signal	VERB
gs-3446	85	4	:	:	PUNCT
gs-3446	85	5	involved	involve	VERB
gs-3446	85	6	in	in	ADP
gs-3446	85	7	cell	cell	NOUN
gs-3446	85	8	fate	fate	NOUN
gs-3446	85	9	determination	determination	NOUN
gs-3446	85	10	and	and	CCONJ
gs-3446	85	11	maintenance	maintenance	NOUN
gs-3446	85	12	of	of	ADP
gs-3446	85	13	stem	stem	NOUN
gs-3446	85	14	cell	cell	NOUN
gs-3446	85	15	populations	population	NOUN
gs-3446	85	16	.	.	PUNCT
gs-3446	86	1	●	●	PUNCT
gs-3446	86	2	hedgehog	hedgehog	NOUN
gs-3446	86	3	signaling	signaling	NOUN
gs-3446	86	4	:	:	PUNCT
gs-3446	86	5	plays	play	VERB
gs-3446	86	6	a	a	DET
gs-3446	86	7	role	role	NOUN
gs-3446	86	8	in	in	ADP
gs-3446	86	9	tissue	tissue	NOUN
gs-3446	86	10	patterning	patterning	NOUN
gs-3446	86	11	and	and	CCONJ
gs-3446	86	12	repair	repair	NOUN
gs-3446	86	13	.	.	PUNCT
gs-3446	87	1	●	●	PUNCT
gs-3446	87	2	extracellular	extracellular	ADJ
gs-3446	87	3	matrix	matrix	NOUN
gs-3446	87	4	(	(	PUNCT
gs-3446	87	5	ecm	ecm	NOUN
gs-3446	87	6	)	)	PUNCT
gs-3446	87	7	interactions	interaction	NOUN
gs-3446	87	8	:	:	PUNCT
gs-3446	87	9	the	the	DET
gs-3446	87	10	ecm	ecm	NOUN
gs-3446	87	11	provides	provide	VERB
gs-3446	87	12	structural	structural	ADJ
gs-3446	87	13	and	and	CCONJ
gs-3446	87	14	biochemical	biochemical	ADJ
gs-3446	87	15	cues	cue	NOUN
gs-3446	87	16	that	that	PRON
gs-3446	87	17	influence	influence	NOUN
gs-3446	87	18	stem	stem	NOUN
gs-3446	87	19	cell	cell	NOUN
gs-3446	87	20	behavior	behavior	NOUN
gs-3446	87	21	and	and	CCONJ
gs-3446	87	22	lineage	lineage	NOUN
gs-3446	87	23	specification	specification	NOUN
gs-3446	87	24	(	(	PUNCT
gs-3446	87	25	morrison	morrison	PROPN
gs-3446	87	26	et	et	PROPN
gs-3446	87	27	al	al	PROPN
gs-3446	87	28	.	.	PROPN
gs-3446	87	29	2008	2008	NUM
gs-3446	87	30	)	)	PUNCT
gs-3446	87	31	.	.	PUNCT
gs-3446	88	1	stem	stem	NOUN
gs-3446	88	2	cells	cell	NOUN
gs-3446	88	3	in	in	ADP
gs-3446	88	4	regeneration	regeneration	NOUN
gs-3446	88	5	stem	stem	NOUN
gs-3446	88	6	cells	cell	NOUN
gs-3446	88	7	play	play	VERB
gs-3446	88	8	a	a	DET
gs-3446	88	9	pivotal	pivotal	ADJ
gs-3446	88	10	role	role	NOUN
gs-3446	88	11	in	in	ADP
gs-3446	88	12	tissue	tissue	NOUN
gs-3446	88	13	repair	repair	NOUN
gs-3446	88	14	and	and	CCONJ
gs-3446	88	15	regeneration	regeneration	NOUN
gs-3446	88	16	following	follow	VERB
gs-3446	88	17	injury	injury	NOUN
gs-3446	88	18	or	or	CCONJ
gs-3446	88	19	disease	disease	NOUN
gs-3446	88	20	.	.	PUNCT
gs-3446	89	1	various	various	ADJ
gs-3446	89	2	adult	adult	NOUN
gs-3446	89	3	stem	stem	NOUN
gs-3446	89	4	cell	cell	NOUN
gs-3446	89	5	populations	population	NOUN
gs-3446	89	6	contribute	contribute	VERB
gs-3446	89	7	to	to	ADP
gs-3446	89	8	tissue	tissue	NOUN
gs-3446	89	9	homeostasis	homeostasis	NOUN
gs-3446	89	10	and	and	CCONJ
gs-3446	89	11	repair	repair	NOUN
gs-3446	89	12	,	,	PUNCT
gs-3446	89	13	including	include	VERB
gs-3446	89	14	:	:	PUNCT
gs-3446	89	15	georgian	georgian	ADJ
gs-3446	89	16	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3446	89	17	მეცნიერები	მეცნიერები	NOUN
gs-3446	89	18	ტ.	ტ.	VERB
gs-3446	89	19	7	7	NUM
gs-3446	89	20	n	n	PRON
gs-3446	89	21	1	1	NUM
gs-3446	89	22	,	,	PUNCT
gs-3446	89	23	2025	2025	NUM
gs-3446	89	24	277	277	NUM
gs-3446	89	25	●	●	NUM
gs-3446	89	26	hematopoietic	hematopoietic	ADJ
gs-3446	89	27	stem	stem	NOUN
gs-3446	89	28	cells	cell	NOUN
gs-3446	89	29	(	(	PUNCT
gs-3446	89	30	hscs	hsc	NOUN
gs-3446	89	31	):	):	PUNCT
gs-3446	89	32	responsible	responsible	ADJ
gs-3446	89	33	for	for	ADP
gs-3446	89	34	continuous	continuous	ADJ
gs-3446	89	35	blood	blood	NOUN
gs-3446	89	36	cell	cell	NOUN
gs-3446	89	37	production	production	NOUN
gs-3446	89	38	in	in	ADP
gs-3446	89	39	the	the	DET
gs-3446	89	40	bone	bone	NOUN
gs-3446	89	41	marrow	marrow	NOUN
gs-3446	89	42	.	.	PUNCT
gs-3446	90	1	●	●	PUNCT
gs-3446	90	2	mesenchymal	mesenchymal	ADJ
gs-3446	90	3	stem	stem	NOUN
gs-3446	90	4	cells	cell	NOUN
gs-3446	90	5	(	(	PUNCT
gs-3446	90	6	mscs	msc	NOUN
gs-3446	90	7	):	):	PUNCT
gs-3446	90	8	found	find	VERB
gs-3446	90	9	in	in	ADP
gs-3446	90	10	multiple	multiple	ADJ
gs-3446	90	11	tissues	tissue	NOUN
gs-3446	90	12	,	,	PUNCT
gs-3446	90	13	including	include	VERB
gs-3446	90	14	bone	bone	NOUN
gs-3446	90	15	marrow	marrow	NOUN
gs-3446	90	16	and	and	CCONJ
gs-3446	90	17	adipose	adipose	ADJ
gs-3446	90	18	tissue	tissue	NOUN
gs-3446	90	19	,	,	PUNCT
gs-3446	90	20	and	and	CCONJ
gs-3446	90	21	can	can	AUX
gs-3446	90	22	differentiate	differentiate	VERB
gs-3446	90	23	into	into	ADP
gs-3446	90	24	osteocytes	osteocyte	NOUN
gs-3446	90	25	,	,	PUNCT
gs-3446	90	26	chondrocytes	chondrocyte	NOUN
gs-3446	90	27	,	,	PUNCT
gs-3446	90	28	and	and	CCONJ
gs-3446	90	29	adipocytes	adipocyte	NOUN
gs-3446	90	30	.	.	PUNCT
gs-3446	91	1	●	●	PUNCT
gs-3446	91	2	neural	neural	ADJ
gs-3446	91	3	stem	stem	NOUN
gs-3446	91	4	cells	cell	NOUN
gs-3446	91	5	(	(	PUNCT
gs-3446	91	6	nscs	nscs	PROPN
gs-3446	91	7	):	):	PUNCT
gs-3446	91	8	located	locate	VERB
gs-3446	91	9	in	in	ADP
gs-3446	91	10	the	the	DET
gs-3446	91	11	brain	brain	NOUN
gs-3446	91	12	,	,	PUNCT
gs-3446	91	13	contributing	contribute	VERB
gs-3446	91	14	to	to	ADP
gs-3446	91	15	neurogenesis	neurogenesis	NOUN
gs-3446	91	16	and	and	CCONJ
gs-3446	91	17	potential	potential	ADJ
gs-3446	91	18	treatments	treatment	NOUN
gs-3446	91	19	for	for	ADP
gs-3446	91	20	neurodegenerative	neurodegenerative	ADJ
gs-3446	91	21	disorders	disorder	NOUN
gs-3446	91	22	.	.	PUNCT
gs-3446	92	1	●	●	PUNCT
gs-3446	92	2	epithelial	epithelial	ADJ
gs-3446	92	3	and	and	CCONJ
gs-3446	92	4	epidermal	epidermal	ADJ
gs-3446	92	5	stem	stem	NOUN
gs-3446	92	6	cells	cell	NOUN
gs-3446	92	7	:	:	PUNCT
gs-3446	92	8	essential	essential	ADJ
gs-3446	92	9	for	for	ADP
gs-3446	92	10	skin	skin	NOUN
gs-3446	92	11	and	and	CCONJ
gs-3446	92	12	gut	gut	NOUN
gs-3446	92	13	lining	lining	NOUN
gs-3446	92	14	regeneration	regeneration	NOUN
gs-3446	92	15	.	.	PUNCT
gs-3446	93	1	advances	advance	NOUN
gs-3446	93	2	in	in	ADP
gs-3446	93	3	stem	stem	NOUN
gs-3446	93	4	cell	cell	NOUN
gs-3446	93	5	-	-	PUNCT
gs-3446	93	6	based	base	VERB
gs-3446	93	7	regenerative	regenerative	ADJ
gs-3446	93	8	medicine	medicine	NOUN
gs-3446	93	9	regenerative	regenerative	ADJ
gs-3446	93	10	medicine	medicine	NOUN
gs-3446	93	11	seeks	seek	VERB
gs-3446	93	12	to	to	ADP
gs-3446	93	13	harness	harness	NOUN
gs-3446	93	14	stem	stem	NOUN
gs-3446	93	15	cell	cell	NOUN
gs-3446	93	16	potential	potential	NOUN
gs-3446	93	17	to	to	PART
gs-3446	93	18	repair	repair	VERB
gs-3446	93	19	damaged	damage	VERB
gs-3446	93	20	tissues	tissue	NOUN
gs-3446	93	21	and	and	CCONJ
gs-3446	93	22	organs	organ	NOUN
gs-3446	93	23	.	.	PUNCT
gs-3446	94	1	key	key	ADJ
gs-3446	94	2	advancements	advancement	NOUN
gs-3446	94	3	include	include	VERB
gs-3446	94	4	:	:	PUNCT
gs-3446	94	5	●	●	NUM
gs-3446	94	6	stem	stem	NOUN
gs-3446	94	7	cell	cell	NOUN
gs-3446	94	8	transplantation	transplantation	NOUN
gs-3446	94	9	:	:	PUNCT
gs-3446	94	10	bone	bone	NOUN
gs-3446	94	11	marrow	marrow	NOUN
gs-3446	94	12	transplants	transplant	NOUN
gs-3446	94	13	have	have	AUX
gs-3446	94	14	been	be	AUX
gs-3446	94	15	successfully	successfully	ADV
gs-3446	94	16	used	use	VERB
gs-3446	94	17	to	to	PART
gs-3446	94	18	treat	treat	VERB
gs-3446	94	19	hematological	hematological	ADJ
gs-3446	94	20	disorders	disorder	NOUN
gs-3446	94	21	.	.	PUNCT
gs-3446	95	1	●	●	PUNCT
gs-3446	95	2	tissue	tissue	NOUN
gs-3446	95	3	engineering	engineering	NOUN
gs-3446	95	4	:	:	PUNCT
gs-3446	95	5	the	the	DET
gs-3446	95	6	combination	combination	NOUN
gs-3446	95	7	of	of	ADP
gs-3446	95	8	stem	stem	NOUN
gs-3446	95	9	cells	cell	NOUN
gs-3446	95	10	with	with	ADP
gs-3446	95	11	biomaterials	biomaterial	NOUN
gs-3446	95	12	to	to	PART
gs-3446	95	13	create	create	VERB
gs-3446	95	14	functional	functional	ADJ
gs-3446	95	15	tissues	tissue	NOUN
gs-3446	95	16	for	for	ADP
gs-3446	95	17	transplantation	transplantation	NOUN
gs-3446	95	18	.	.	PUNCT
gs-3446	96	1	●	●	NUM
gs-3446	96	2	organoid	organoid	NOUN
gs-3446	96	3	technology	technology	NOUN
gs-3446	96	4	:	:	PUNCT
gs-3446	96	5	generation	generation	NOUN
gs-3446	96	6	of	of	ADP
gs-3446	96	7	miniaturized	miniaturized	ADJ
gs-3446	96	8	,	,	PUNCT
gs-3446	96	9	functional	functional	ADJ
gs-3446	96	10	tissue	tissue	NOUN
gs-3446	96	11	models	model	NOUN
gs-3446	96	12	for	for	ADP
gs-3446	96	13	disease	disease	NOUN
gs-3446	96	14	modeling	modeling	NOUN
gs-3446	96	15	and	and	CCONJ
gs-3446	96	16	drug	drug	NOUN
gs-3446	96	17	testing	testing	NOUN
gs-3446	96	18	.	.	PUNCT
gs-3446	97	1	●	●	PUNCT
gs-3446	97	2	gene	gene	NOUN
gs-3446	97	3	editing	editing	NOUN
gs-3446	97	4	and	and	CCONJ
gs-3446	97	5	crispr	crispr	ADJ
gs-3446	97	6	technology	technology	NOUN
gs-3446	97	7	:	:	PUNCT
gs-3446	97	8	precise	precise	ADJ
gs-3446	97	9	genetic	genetic	ADJ
gs-3446	97	10	modifications	modification	NOUN
gs-3446	97	11	in	in	ADP
gs-3446	97	12	stem	stem	NOUN
gs-3446	97	13	cells	cell	NOUN
gs-3446	97	14	for	for	ADP
gs-3446	97	15	personalized	personalize	VERB
gs-3446	97	16	therapeutic	therapeutic	ADJ
gs-3446	97	17	applications	application	NOUN
gs-3446	97	18	.	.	PUNCT
gs-3446	98	1	challenges	challenge	NOUN
gs-3446	98	2	and	and	CCONJ
gs-3446	98	3	ethical	ethical	ADJ
gs-3446	98	4	considerations	consideration	NOUN
gs-3446	98	5	despite	despite	SCONJ
gs-3446	98	6	the	the	DET
gs-3446	98	7	promise	promise	NOUN
gs-3446	98	8	of	of	ADP
gs-3446	98	9	stem	stem	NOUN
gs-3446	98	10	cell	cell	NOUN
gs-3446	98	11	therapies	therapy	NOUN
gs-3446	98	12	,	,	PUNCT
gs-3446	98	13	several	several	ADJ
gs-3446	98	14	challenges	challenge	NOUN
gs-3446	98	15	must	must	AUX
gs-3446	98	16	be	be	AUX
gs-3446	98	17	addressed	address	VERB
gs-3446	98	18	:	:	PUNCT
gs-3446	98	19	●	●	NUM
gs-3446	98	20	ethical	ethical	ADJ
gs-3446	98	21	concerns	concern	NOUN
gs-3446	98	22	:	:	PUNCT
gs-3446	98	23	the	the	DET
gs-3446	98	24	use	use	NOUN
gs-3446	98	25	of	of	ADP
gs-3446	98	26	embryonic	embryonic	ADJ
gs-3446	98	27	stem	stem	NOUN
gs-3446	98	28	cells	cell	NOUN
gs-3446	98	29	raises	raise	VERB
gs-3446	98	30	moral	moral	ADJ
gs-3446	98	31	and	and	CCONJ
gs-3446	98	32	legal	legal	ADJ
gs-3446	98	33	issues	issue	NOUN
gs-3446	98	34	,	,	PUNCT
gs-3446	98	35	prompting	prompt	VERB
gs-3446	98	36	research	research	NOUN
gs-3446	98	37	into	into	ADP
gs-3446	98	38	alternative	alternative	ADJ
gs-3446	98	39	sources	source	NOUN
gs-3446	98	40	such	such	ADJ
gs-3446	98	41	as	as	ADP
gs-3446	98	42	ipscs	ipsc	NOUN
gs-3446	98	43	.	.	PUNCT
gs-3446	99	1	●	●	NUM
gs-3446	99	2	immune	immune	ADJ
gs-3446	99	3	rejection	rejection	NOUN
gs-3446	99	4	:	:	PUNCT
gs-3446	99	5	allogeneic	allogeneic	ADJ
gs-3446	99	6	stem	stem	NOUN
gs-3446	99	7	cell	cell	NOUN
gs-3446	99	8	transplants	transplant	NOUN
gs-3446	99	9	may	may	AUX
gs-3446	99	10	trigger	trigger	VERB
gs-3446	99	11	immune	immune	ADJ
gs-3446	99	12	responses	response	NOUN
gs-3446	99	13	,	,	PUNCT
gs-3446	99	14	necessitating	necessitate	VERB
gs-3446	99	15	immunosuppressive	immunosuppressive	ADJ
gs-3446	99	16	strategies	strategy	NOUN
gs-3446	99	17	.	.	PUNCT
gs-3446	100	1	●	●	PUNCT
gs-3446	100	2	tumorigenicity	tumorigenicity	NOUN
gs-3446	100	3	:	:	PUNCT
gs-3446	100	4	the	the	DET
gs-3446	100	5	uncontrolled	uncontrolled	ADJ
gs-3446	100	6	proliferation	proliferation	NOUN
gs-3446	100	7	of	of	ADP
gs-3446	100	8	stem	stem	NOUN
gs-3446	100	9	cells	cell	NOUN
gs-3446	100	10	poses	pose	VERB
gs-3446	100	11	a	a	DET
gs-3446	100	12	risk	risk	NOUN
gs-3446	100	13	of	of	ADP
gs-3446	100	14	tumor	tumor	NOUN
gs-3446	100	15	formation	formation	NOUN
gs-3446	100	16	,	,	PUNCT
gs-3446	100	17	requiring	require	VERB
gs-3446	100	18	stringent	stringent	ADJ
gs-3446	100	19	safety	safety	NOUN
gs-3446	100	20	measures	measure	NOUN
gs-3446	100	21	.	.	PUNCT
gs-3446	101	1	●	●	PUNCT
gs-3446	101	2	regulatory	regulatory	ADJ
gs-3446	101	3	hurdles	hurdle	NOUN
gs-3446	101	4	:	:	PUNCT
gs-3446	101	5	ensuring	ensure	VERB
gs-3446	101	6	the	the	DET
gs-3446	101	7	safe	safe	ADJ
gs-3446	101	8	and	and	CCONJ
gs-3446	101	9	effective	effective	ADJ
gs-3446	101	10	application	application	NOUN
gs-3446	101	11	of	of	ADP
gs-3446	101	12	stem	stem	NOUN
gs-3446	101	13	cell	cell	NOUN
gs-3446	101	14	therapies	therapy	NOUN
gs-3446	101	15	through	through	ADP
gs-3446	101	16	rigorous	rigorous	ADJ
gs-3446	101	17	clinical	clinical	ADJ
gs-3446	101	18	trials	trial	NOUN
gs-3446	101	19	and	and	CCONJ
gs-3446	101	20	approvals	approval	NOUN
gs-3446	101	21	(	(	PUNCT
gs-3446	101	22	halpern	halpern	PROPN
gs-3446	101	23	et	et	PROPN
gs-3446	101	24	al	al	PROPN
gs-3446	101	25	.	.	PROPN
gs-3446	101	26	2019	2019	NUM
gs-3446	101	27	)	)	PUNCT
gs-3446	101	28	.	.	PUNCT
gs-3446	102	1	future	future	ADJ
gs-3446	102	2	directions	direction	NOUN
gs-3446	102	3	the	the	DET
gs-3446	102	4	future	future	NOUN
gs-3446	102	5	of	of	ADP
gs-3446	102	6	stem	stem	NOUN
gs-3446	102	7	cell	cell	NOUN
gs-3446	102	8	research	research	NOUN
gs-3446	102	9	holds	hold	VERB
gs-3446	102	10	great	great	ADJ
gs-3446	102	11	promise	promise	NOUN
gs-3446	102	12	,	,	PUNCT
gs-3446	102	13	with	with	ADP
gs-3446	102	14	ongoing	ongoing	ADJ
gs-3446	102	15	efforts	effort	NOUN
gs-3446	102	16	to	to	PART
gs-3446	102	17	enhance	enhance	VERB
gs-3446	102	18	therapeutic	therapeutic	ADJ
gs-3446	102	19	efficacy	efficacy	NOUN
gs-3446	102	20	and	and	CCONJ
gs-3446	102	21	safety	safety	NOUN
gs-3446	102	22	.	.	PUNCT
gs-3446	103	1	emerging	emerge	VERB
gs-3446	103	2	trends	trend	NOUN
gs-3446	103	3	include	include	VERB
gs-3446	103	4	:	:	PUNCT
gs-3446	103	5	●	●	PUNCT
gs-3446	103	6	bioengineering	bioengineering	NOUN
gs-3446	103	7	and	and	CCONJ
gs-3446	103	8	synthetic	synthetic	ADJ
gs-3446	103	9	biology	biology	NOUN
gs-3446	103	10	:	:	PUNCT
gs-3446	103	11	developing	develop	VERB
gs-3446	103	12	artificial	artificial	ADJ
gs-3446	103	13	niches	niche	NOUN
gs-3446	103	14	and	and	CCONJ
gs-3446	103	15	biomimetic	biomimetic	ADJ
gs-3446	103	16	environments	environment	NOUN
gs-3446	103	17	to	to	PART
gs-3446	103	18	optimize	optimize	VERB
gs-3446	103	19	stem	stem	NOUN
gs-3446	103	20	cell	cell	NOUN
gs-3446	103	21	function	function	NOUN
gs-3446	103	22	.	.	PUNCT
gs-3446	104	1	georgian	georgian	ADJ
gs-3446	104	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	104	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	104	4	ტ.	ტ.	VERB
gs-3446	104	5	7	7	NUM
gs-3446	104	6	n	n	PRON
gs-3446	104	7	1	1	NUM
gs-3446	104	8	,	,	PUNCT
gs-3446	104	9	2025	2025	NUM
gs-3446	104	10	278	278	NUM
gs-3446	104	11	●	●	ADJ
gs-3446	104	12	personalized	personalized	ADJ
gs-3446	104	13	medicine	medicine	NOUN
gs-3446	104	14	:	:	PUNCT
gs-3446	104	15	utilizing	utilize	VERB
gs-3446	104	16	patient	patient	NOUN
gs-3446	104	17	-	-	PUNCT
gs-3446	104	18	derived	derive	VERB
gs-3446	104	19	ipscs	ipscs	NOUN
gs-3446	104	20	for	for	ADP
gs-3446	104	21	tailored	tailored	ADJ
gs-3446	104	22	treatments	treatment	NOUN
gs-3446	104	23	and	and	CCONJ
gs-3446	104	24	drug	drug	NOUN
gs-3446	104	25	testing	testing	NOUN
gs-3446	104	26	.	.	PUNCT
gs-3446	105	1	●	●	PUNCT
gs-3446	105	2	whole	whole	ADJ
gs-3446	105	3	organ	organ	NOUN
gs-3446	105	4	regeneration	regeneration	NOUN
gs-3446	105	5	:	:	PUNCT
gs-3446	105	6	exploring	explore	VERB
gs-3446	105	7	3d	3d	NOUN
gs-3446	105	8	bioprinting	bioprinting	NOUN
gs-3446	105	9	and	and	CCONJ
gs-3446	105	10	organoid	organoid	PROPN
gs-3446	105	11	technology	technology	NOUN
gs-3446	105	12	to	to	PART
gs-3446	105	13	create	create	VERB
gs-3446	105	14	transplantable	transplantable	ADJ
gs-3446	105	15	organs	organ	NOUN
gs-3446	105	16	.	.	PUNCT
gs-3446	106	1	stem	stem	NOUN
gs-3446	106	2	cell	cell	NOUN
gs-3446	106	3	systems	system	NOUN
gs-3446	106	4	and	and	CCONJ
gs-3446	106	5	their	their	PRON
gs-3446	106	6	regenerative	regenerative	ADJ
gs-3446	106	7	potential	potential	ADJ
gs-3446	106	8	offer	offer	NOUN
gs-3446	106	9	a	a	DET
gs-3446	106	10	transformative	transformative	ADJ
gs-3446	106	11	approach	approach	NOUN
gs-3446	106	12	to	to	ADP
gs-3446	106	13	medicine	medicine	NOUN
gs-3446	106	14	and	and	CCONJ
gs-3446	106	15	tissue	tissue	NOUN
gs-3446	106	16	engineering	engineering	NOUN
gs-3446	106	17	.	.	PUNCT
gs-3446	107	1	continued	continue	VERB
gs-3446	107	2	research	research	NOUN
gs-3446	107	3	into	into	ADP
gs-3446	107	4	stem	stem	NOUN
gs-3446	107	5	cell	cell	NOUN
gs-3446	107	6	biology	biology	NOUN
gs-3446	107	7	,	,	PUNCT
gs-3446	107	8	regulatory	regulatory	ADJ
gs-3446	107	9	mechanisms	mechanism	NOUN
gs-3446	107	10	,	,	PUNCT
gs-3446	107	11	and	and	CCONJ
gs-3446	107	12	clinical	clinical	ADJ
gs-3446	107	13	applications	application	NOUN
gs-3446	107	14	will	will	AUX
gs-3446	107	15	pave	pave	VERB
gs-3446	107	16	the	the	DET
gs-3446	107	17	way	way	NOUN
gs-3446	107	18	for	for	SCONJ
gs-3446	107	19	novel	novel	ADJ
gs-3446	107	20	therapies	therapy	NOUN
gs-3446	107	21	addressing	address	VERB
gs-3446	107	22	previously	previously	ADV
gs-3446	107	23	untreatable	untreatable	ADJ
gs-3446	107	24	conditions	condition	NOUN
gs-3446	107	25	.	.	PUNCT
gs-3446	108	1	while	while	SCONJ
gs-3446	108	2	challenges	challenge	NOUN
gs-3446	108	3	remain	remain	VERB
gs-3446	108	4	,	,	PUNCT
gs-3446	108	5	the	the	DET
gs-3446	108	6	rapid	rapid	ADJ
gs-3446	108	7	advancements	advancement	NOUN
gs-3446	108	8	in	in	ADP
gs-3446	108	9	this	this	DET
gs-3446	108	10	field	field	NOUN
gs-3446	108	11	bring	bring	VERB
gs-3446	108	12	us	we	PRON
gs-3446	108	13	closer	close	ADV
gs-3446	108	14	to	to	ADP
gs-3446	108	15	unlocking	unlock	VERB
gs-3446	108	16	the	the	DET
gs-3446	108	17	full	full	ADJ
gs-3446	108	18	potential	potential	NOUN
gs-3446	108	19	of	of	ADP
gs-3446	108	20	stem	stem	NOUN
gs-3446	108	21	cells	cell	NOUN
gs-3446	108	22	in	in	ADP
gs-3446	108	23	regenerative	regenerative	ADJ
gs-3446	108	24	medicine	medicine	NOUN
gs-3446	108	25	and	and	CCONJ
gs-3446	108	26	beyond	beyond	ADP
gs-3446	108	27	(	(	PUNCT
gs-3446	108	28	sulashvili	sulashvili	NOUN
gs-3446	108	29	et	et	PROPN
gs-3446	108	30	al	al	PROPN
gs-3446	108	31	.	.	PROPN
gs-3446	108	32	,	,	PUNCT
gs-3446	108	33	2022	2022	NUM
gs-3446	108	34	)	)	PUNCT
gs-3446	108	35	.	.	PUNCT
gs-3446	109	1	stem	stem	NOUN
gs-3446	109	2	cells	cell	NOUN
gs-3446	109	3	genes	gene	NOUN
gs-3446	109	4	stem	stem	VERB
gs-3446	109	5	cells	cell	NOUN
gs-3446	109	6	are	be	AUX
gs-3446	109	7	broadly	broadly	ADV
gs-3446	109	8	categorized	categorize	VERB
gs-3446	109	9	into	into	ADP
gs-3446	109	10	embryonic	embryonic	ADJ
gs-3446	109	11	stem	stem	NOUN
gs-3446	109	12	cells	cell	NOUN
gs-3446	109	13	(	(	PUNCT
gs-3446	109	14	escs	esc	NOUN
gs-3446	109	15	)	)	PUNCT
gs-3446	109	16	,	,	PUNCT
gs-3446	109	17	adult	adult	NOUN
gs-3446	109	18	stem	stem	NOUN
gs-3446	109	19	cells	cell	NOUN
gs-3446	109	20	(	(	PUNCT
gs-3446	109	21	ascs	asc	NOUN
gs-3446	109	22	)	)	PUNCT
gs-3446	109	23	,	,	PUNCT
gs-3446	109	24	and	and	CCONJ
gs-3446	109	25	induced	induce	VERB
gs-3446	109	26	pluripotent	pluripotent	ADJ
gs-3446	109	27	stem	stem	NOUN
gs-3446	109	28	cells	cell	NOUN
gs-3446	109	29	(	(	PUNCT
gs-3446	109	30	ipscs	ipscs	NOUN
gs-3446	109	31	):	):	PUNCT
gs-3446	109	32	embryonic	embryonic	ADJ
gs-3446	109	33	stem	stem	NOUN
gs-3446	109	34	cells	cell	NOUN
gs-3446	109	35	are	be	AUX
gs-3446	109	36	derived	derive	VERB
gs-3446	109	37	from	from	ADP
gs-3446	109	38	the	the	DET
gs-3446	109	39	inner	inner	ADJ
gs-3446	109	40	cell	cell	NOUN
gs-3446	109	41	mass	mass	NOUN
gs-3446	109	42	of	of	ADP
gs-3446	109	43	blastocysts	blastocyst	NOUN
gs-3446	109	44	and	and	CCONJ
gs-3446	109	45	are	be	AUX
gs-3446	109	46	pluripotent	pluripotent	ADJ
gs-3446	109	47	,	,	PUNCT
gs-3446	109	48	capable	capable	ADJ
gs-3446	109	49	of	of	ADP
gs-3446	109	50	differentiating	differentiate	VERB
gs-3446	109	51	into	into	ADP
gs-3446	109	52	nearly	nearly	ADV
gs-3446	109	53	all	all	DET
gs-3446	109	54	cell	cell	NOUN
gs-3446	109	55	types	type	NOUN
gs-3446	109	56	.	.	PUNCT
gs-3446	110	1	their	their	PRON
gs-3446	110	2	genetic	genetic	ADJ
gs-3446	110	3	stability	stability	NOUN
gs-3446	110	4	and	and	CCONJ
gs-3446	110	5	regulatory	regulatory	ADJ
gs-3446	110	6	networks	network	NOUN
gs-3446	110	7	,	,	PUNCT
gs-3446	110	8	governed	govern	VERB
gs-3446	110	9	by	by	ADP
gs-3446	110	10	key	key	ADJ
gs-3446	110	11	transcription	transcription	NOUN
gs-3446	110	12	factors	factor	NOUN
gs-3446	110	13	such	such	ADJ
gs-3446	110	14	as	as	ADP
gs-3446	110	15	oct4	oct4	NOUN
gs-3446	110	16	,	,	PUNCT
gs-3446	110	17	sox2	sox2	NOUN
gs-3446	110	18	,	,	PUNCT
gs-3446	110	19	and	and	CCONJ
gs-3446	110	20	nanog	nanog	PROPN
gs-3446	110	21	,	,	PUNCT
gs-3446	110	22	enable	enable	VERB
gs-3446	110	23	their	their	PRON
gs-3446	110	24	pluripotency	pluripotency	NOUN
gs-3446	110	25	and	and	CCONJ
gs-3446	110	26	selfrenewal	selfrenewal	NOUN
gs-3446	110	27	(	(	PUNCT
gs-3446	110	28	singh	singh	PROPN
gs-3446	110	29	et	et	PROPN
gs-3446	110	30	al	al	PROPN
gs-3446	110	31	.	.	PROPN
gs-3446	110	32	2015	2015	NUM
gs-3446	110	33	)	)	PUNCT
gs-3446	110	34	.	.	PUNCT
gs-3446	111	1	adult	adult	NOUN
gs-3446	111	2	stem	stem	NOUN
gs-3446	111	3	cells	cell	NOUN
gs-3446	111	4	,	,	PUNCT
gs-3446	111	5	found	find	VERB
gs-3446	111	6	in	in	ADP
gs-3446	111	7	various	various	ADJ
gs-3446	111	8	tissues	tissue	NOUN
gs-3446	111	9	,	,	PUNCT
gs-3446	111	10	are	be	AUX
gs-3446	111	11	multipotent	multipotent	NOUN
gs-3446	111	12	and	and	CCONJ
gs-3446	111	13	responsible	responsible	ADJ
gs-3446	111	14	for	for	ADP
gs-3446	111	15	tissue	tissue	NOUN
gs-3446	111	16	maintenance	maintenance	NOUN
gs-3446	111	17	and	and	CCONJ
gs-3446	111	18	repair	repair	NOUN
gs-3446	111	19	.	.	PUNCT
gs-3446	112	1	hematopoietic	hematopoietic	ADJ
gs-3446	112	2	stem	stem	NOUN
gs-3446	112	3	cells	cell	NOUN
gs-3446	112	4	and	and	CCONJ
gs-3446	112	5	mesenchymal	mesenchymal	NOUN
gs-3446	112	6	stem	stem	NOUN
gs-3446	112	7	cells	cell	NOUN
gs-3446	112	8	are	be	AUX
gs-3446	112	9	well	well	ADV
gs-3446	112	10	-	-	PUNCT
gs-3446	112	11	studied	study	VERB
gs-3446	112	12	examples	example	NOUN
gs-3446	112	13	.	.	PUNCT
gs-3446	113	1	their	their	PRON
gs-3446	113	2	genetic	genetic	ADJ
gs-3446	113	3	expression	expression	NOUN
gs-3446	113	4	profiles	profile	NOUN
gs-3446	113	5	are	be	AUX
gs-3446	113	6	more	more	ADJ
gs-3446	113	7	lineage	lineage	NOUN
gs-3446	113	8	-	-	PUNCT
gs-3446	113	9	restricted	restrict	VERB
gs-3446	113	10	compared	compare	VERB
gs-3446	113	11	to	to	ADP
gs-3446	113	12	embryonic	embryonic	VERB
gs-3446	113	13	stem	stem	NOUN
gs-3446	113	14	cells	cell	NOUN
gs-3446	113	15	,	,	PUNCT
gs-3446	113	16	influenced	influence	VERB
gs-3446	113	17	by	by	ADP
gs-3446	113	18	their	their	PRON
gs-3446	113	19	niche	niche	NOUN
gs-3446	113	20	and	and	CCONJ
gs-3446	113	21	microenvironment	microenvironment	NOUN
gs-3446	113	22	.	.	PUNCT
gs-3446	114	1	induced	induce	VERB
gs-3446	114	2	pluripotent	pluripotent	ADJ
gs-3446	114	3	stem	stem	NOUN
gs-3446	114	4	cells	cell	NOUN
gs-3446	114	5	are	be	AUX
gs-3446	114	6	reprogrammed	reprogramme	VERB
gs-3446	114	7	from	from	ADP
gs-3446	114	8	somatic	somatic	ADJ
gs-3446	114	9	cells	cell	NOUN
gs-3446	114	10	(	(	PUNCT
gs-3446	114	11	figure	figure	NOUN
gs-3446	114	12	2	2	NUM
gs-3446	114	13	)	)	PUNCT
gs-3446	114	14	using	use	VERB
gs-3446	114	15	factors	factor	NOUN
gs-3446	114	16	such	such	ADJ
gs-3446	114	17	as	as	ADP
gs-3446	114	18	oct4	oct4	NOUN
gs-3446	114	19	,	,	PUNCT
gs-3446	114	20	sox2	sox2	NOUN
gs-3446	114	21	,	,	PUNCT
gs-3446	114	22	klf4	klf4	NOUN
gs-3446	114	23	,	,	PUNCT
gs-3446	114	24	and	and	CCONJ
gs-3446	114	25	c	c	X
gs-3446	114	26	-	-	PUNCT
gs-3446	114	27	myc	myc	NOUN
gs-3446	114	28	.	.	PUNCT
gs-3446	115	1	they	they	PRON
gs-3446	115	2	offer	offer	VERB
gs-3446	115	3	an	an	DET
gs-3446	115	4	ethical	ethical	ADJ
gs-3446	115	5	and	and	CCONJ
gs-3446	115	6	personalized	personalized	ADJ
gs-3446	115	7	alternative	alternative	NOUN
gs-3446	115	8	to	to	PART
gs-3446	115	9	embryonic	embryonic	VERB
gs-3446	115	10	stem	stem	NOUN
gs-3446	115	11	cells	cell	NOUN
gs-3446	115	12	.	.	PUNCT
gs-3446	116	1	advances	advance	NOUN
gs-3446	116	2	in	in	ADP
gs-3446	116	3	genome	genome	NOUN
gs-3446	116	4	editing	editing	NOUN
gs-3446	116	5	technologies	technology	NOUN
gs-3446	116	6	,	,	PUNCT
gs-3446	116	7	particularly	particularly	ADV
gs-3446	116	8	crispr	crispr	ADJ
gs-3446	116	9	-	-	PUNCT
gs-3446	116	10	cas9	cas9	NOUN
gs-3446	116	11	,	,	PUNCT
gs-3446	116	12	have	have	AUX
gs-3446	116	13	enabled	enable	VERB
gs-3446	116	14	precise	precise	ADJ
gs-3446	116	15	genetic	genetic	ADJ
gs-3446	116	16	modifications	modification	NOUN
gs-3446	116	17	in	in	ADP
gs-3446	116	18	induced	induced	ADJ
gs-3446	116	19	pluripotent	pluripotent	ADJ
gs-3446	116	20	stem	stem	NOUN
gs-3446	116	21	cells	cell	NOUN
gs-3446	116	22	,	,	PUNCT
gs-3446	116	23	enhancing	enhance	VERB
gs-3446	116	24	their	their	PRON
gs-3446	116	25	utility	utility	NOUN
gs-3446	116	26	in	in	ADP
gs-3446	116	27	disease	disease	NOUN
gs-3446	116	28	modeling	modeling	NOUN
gs-3446	116	29	and	and	CCONJ
gs-3446	116	30	therapy	therapy	NOUN
gs-3446	116	31	(	(	PUNCT
gs-3446	116	32	halpern	halpern	PROPN
gs-3446	116	33	et	et	PROPN
gs-3446	116	34	al	al	PROPN
gs-3446	116	35	.	.	PROPN
gs-3446	116	36	2019	2019	NUM
gs-3446	116	37	)	)	PUNCT
gs-3446	116	38	.	.	PUNCT
gs-3446	117	1	the	the	DET
gs-3446	117	2	genetic	genetic	ADJ
gs-3446	117	3	and	and	CCONJ
gs-3446	117	4	epigenetic	epigenetic	ADJ
gs-3446	117	5	landscapes	landscape	NOUN
gs-3446	117	6	of	of	ADP
gs-3446	117	7	stem	stem	NOUN
gs-3446	117	8	cells	cell	NOUN
gs-3446	117	9	are	be	AUX
gs-3446	117	10	critical	critical	ADJ
gs-3446	117	11	for	for	ADP
gs-3446	117	12	their	their	PRON
gs-3446	117	13	function	function	NOUN
gs-3446	117	14	.	.	PUNCT
gs-3446	118	1	transcriptional	transcriptional	ADJ
gs-3446	118	2	regulation	regulation	NOUN
gs-3446	118	3	involves	involve	VERB
gs-3446	118	4	tightly	tightly	ADV
gs-3446	118	5	controlled	control	VERB
gs-3446	118	6	gene	gene	NOUN
gs-3446	118	7	networks	network	NOUN
gs-3446	118	8	,	,	PUNCT
gs-3446	118	9	influenced	influence	VERB
gs-3446	118	10	by	by	ADP
gs-3446	118	11	pathways	pathway	NOUN
gs-3446	118	12	like	like	ADP
gs-3446	118	13	wnt	wnt	PROPN
gs-3446	118	14	/	/	SYM
gs-3446	118	15	β	β	NOUN
gs-3446	118	16	-	-	ADJ
gs-3446	118	17	catenin	catenin	ADJ
gs-3446	118	18	,	,	PUNCT
gs-3446	118	19	notch	notch	NOUN
gs-3446	118	20	,	,	PUNCT
gs-3446	118	21	and	and	CCONJ
gs-3446	118	22	hedgehog	hedgehog	NOUN
gs-3446	118	23	.	.	PUNCT
gs-3446	119	1	these	these	DET
gs-3446	119	2	pathways	pathway	NOUN
gs-3446	119	3	play	play	VERB
gs-3446	119	4	significant	significant	ADJ
gs-3446	119	5	roles	role	NOUN
gs-3446	119	6	in	in	ADP
gs-3446	119	7	stem	stem	NOUN
gs-3446	119	8	cell	cell	NOUN
gs-3446	119	9	fate	fate	NOUN
gs-3446	119	10	decisions	decision	NOUN
gs-3446	119	11	.	.	PUNCT
gs-3446	120	1	epigenetic	epigenetic	ADJ
gs-3446	120	2	modifications	modification	NOUN
gs-3446	120	3	,	,	PUNCT
gs-3446	120	4	including	include	VERB
gs-3446	120	5	dna	dna	PROPN
gs-3446	120	6	methylation	methylation	NOUN
gs-3446	120	7	,	,	PUNCT
gs-3446	120	8	histone	histone	NOUN
gs-3446	120	9	modifications	modification	NOUN
gs-3446	120	10	,	,	PUNCT
gs-3446	120	11	and	and	CCONJ
gs-3446	120	12	non	non	ADJ
gs-3446	120	13	-	-	ADJ
gs-3446	120	14	coding	coding	ADJ
gs-3446	120	15	rnas	rna	NOUN
gs-3446	120	16	,	,	PUNCT
gs-3446	120	17	contribute	contribute	VERB
gs-3446	120	18	to	to	ADP
gs-3446	120	19	dynamic	dynamic	ADJ
gs-3446	120	20	regulation	regulation	NOUN
gs-3446	120	21	of	of	ADP
gs-3446	120	22	stem	stem	NOUN
gs-3446	120	23	cell	cell	NOUN
gs-3446	120	24	gene	gene	NOUN
gs-3446	120	25	expression	expression	NOUN
gs-3446	120	26	.	.	PUNCT
gs-3446	121	1	this	this	DET
gs-3446	121	2	reprogramming	reprogramming	NOUN
gs-3446	121	3	is	be	AUX
gs-3446	121	4	essential	essential	ADJ
gs-3446	121	5	for	for	ADP
gs-3446	121	6	converting	convert	VERB
gs-3446	121	7	somatic	somatic	ADJ
gs-3446	121	8	cells	cell	NOUN
gs-3446	121	9	into	into	ADP
gs-3446	121	10	induced	induced	ADJ
gs-3446	121	11	pluripotent	pluripotent	ADJ
gs-3446	121	12	stem	stem	NOUN
gs-3446	121	13	cells	cell	NOUN
gs-3446	121	14	and	and	CCONJ
gs-3446	121	15	maintaining	maintain	VERB
gs-3446	121	16	plasticity	plasticity	NOUN
gs-3446	121	17	.	.	PUNCT
gs-3446	122	1	accumulation	accumulation	NOUN
gs-3446	122	2	of	of	ADP
gs-3446	122	3	genetic	genetic	ADJ
gs-3446	122	4	mutations	mutation	NOUN
gs-3446	122	5	can	can	AUX
gs-3446	122	6	affect	affect	VERB
gs-3446	122	7	stem	stem	NOUN
gs-3446	122	8	cell	cell	NOUN
gs-3446	122	9	functionality	functionality	NOUN
gs-3446	122	10	,	,	PUNCT
gs-3446	122	11	potentially	potentially	ADV
gs-3446	122	12	leading	lead	VERB
gs-3446	122	13	to	to	ADP
gs-3446	122	14	diseases	disease	NOUN
gs-3446	122	15	such	such	ADJ
gs-3446	122	16	as	as	ADP
gs-3446	122	17	cancer	cancer	NOUN
gs-3446	122	18	.	.	PUNCT
gs-3446	123	1	single	single	ADJ
gs-3446	123	2	-	-	PUNCT
gs-3446	123	3	cell	cell	NOUN
gs-3446	123	4	sequencing	sequencing	NOUN
gs-3446	123	5	has	have	AUX
gs-3446	123	6	provided	provide	VERB
gs-3446	123	7	insights	insight	NOUN
gs-3446	123	8	into	into	ADP
gs-3446	123	9	the	the	DET
gs-3446	123	10	genetic	genetic	ADJ
gs-3446	123	11	heterogeneity	heterogeneity	NOUN
gs-3446	123	12	within	within	ADP
gs-3446	123	13	stem	stem	NOUN
gs-3446	123	14	cell	cell	NOUN
gs-3446	123	15	populations	population	NOUN
gs-3446	123	16	(	(	PUNCT
gs-3446	123	17	singh	singh	PROPN
gs-3446	123	18	et	et	PROPN
gs-3446	123	19	al	al	PROPN
gs-3446	123	20	.	.	PROPN
gs-3446	123	21	2015	2015	NUM
gs-3446	123	22	)	)	PUNCT
gs-3446	123	23	.	.	PUNCT
gs-3446	124	1	applications	application	NOUN
gs-3446	124	2	of	of	ADP
gs-3446	124	3	stem	stem	NOUN
gs-3446	124	4	cells	cell	NOUN
gs-3446	124	5	in	in	ADP
gs-3446	124	6	genetics	genetic	NOUN
gs-3446	124	7	include	include	VERB
gs-3446	124	8	disease	disease	NOUN
gs-3446	124	9	modeling	modeling	NOUN
gs-3446	124	10	,	,	PUNCT
gs-3446	124	11	gene	gene	NOUN
gs-3446	124	12	therapy	therapy	NOUN
gs-3446	124	13	,	,	PUNCT
gs-3446	124	14	regenerative	regenerative	ADJ
gs-3446	124	15	medicine	medicine	NOUN
gs-3446	124	16	,	,	PUNCT
gs-3446	124	17	and	and	CCONJ
gs-3446	124	18	drug	drug	NOUN
gs-3446	124	19	discovery	discovery	NOUN
gs-3446	124	20	.	.	PUNCT
gs-3446	125	1	induced	induce	VERB
gs-3446	125	2	pluripotent	pluripotent	ADJ
gs-3446	125	3	stem	stem	NOUN
gs-3446	125	4	cells	cell	NOUN
gs-3446	125	5	derived	derive	VERB
gs-3446	125	6	from	from	ADP
gs-3446	125	7	patients	patient	NOUN
gs-3446	125	8	allow	allow	VERB
gs-3446	125	9	the	the	DET
gs-3446	125	10	creation	creation	NOUN
gs-3446	125	11	of	of	ADP
gs-3446	125	12	diseasespecific	diseasespecific	NOUN
gs-3446	125	13	models	model	NOUN
gs-3446	125	14	,	,	PUNCT
gs-3446	125	15	enabling	enable	VERB
gs-3446	125	16	the	the	DET
gs-3446	125	17	study	study	NOUN
gs-3446	125	18	of	of	ADP
gs-3446	125	19	genetic	genetic	ADJ
gs-3446	125	20	mutations	mutation	NOUN
gs-3446	125	21	and	and	CCONJ
gs-3446	125	22	pathophysiological	pathophysiological	ADJ
gs-3446	125	23	mechanisms	mechanism	NOUN
gs-3446	125	24	.	.	PUNCT
gs-3446	126	1	these	these	DET
gs-3446	126	2	models	model	NOUN
gs-3446	126	3	have	have	VERB
gs-3446	126	4	advanced	advanced	ADJ
gs-3446	126	5	understanding	understanding	NOUN
gs-3446	126	6	of	of	ADP
gs-3446	126	7	disorders	disorder	NOUN
gs-3446	126	8	like	like	ADP
gs-3446	126	9	alzheimer	alzheimer	PROPN
gs-3446	126	10	’s	’s	PART
gs-3446	126	11	and	and	CCONJ
gs-3446	126	12	parkinson	parkinson	NOUN
gs-3446	126	13	’s	’s	PART
gs-3446	126	14	.	.	PUNCT
gs-3446	127	1	the	the	DET
gs-3446	127	2	convergence	convergence	NOUN
gs-3446	127	3	georgian	georgian	PROPN
gs-3446	127	4	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3446	127	5	მეცნიერები	მეცნიერები	NOUN
gs-3446	127	6	ტ.	ტ.	VERB
gs-3446	127	7	7	7	NUM
gs-3446	127	8	n	n	PRON
gs-3446	127	9	1	1	NUM
gs-3446	127	10	,	,	PUNCT
gs-3446	127	11	2025	2025	NUM
gs-3446	127	12	279	279	NUM
gs-3446	127	13	of	of	ADP
gs-3446	127	14	stem	stem	NOUN
gs-3446	127	15	cells	cell	NOUN
gs-3446	127	16	and	and	CCONJ
gs-3446	127	17	genetic	genetic	ADJ
gs-3446	127	18	engineering	engineering	NOUN
gs-3446	127	19	has	have	AUX
gs-3446	127	20	facilitated	facilitate	VERB
gs-3446	127	21	the	the	DET
gs-3446	127	22	development	development	NOUN
gs-3446	127	23	of	of	ADP
gs-3446	127	24	gene	gene	NOUN
gs-3446	127	25	therapies	therapy	NOUN
gs-3446	127	26	.	.	PUNCT
gs-3446	128	1	hematopoietic	hematopoietic	ADJ
gs-3446	128	2	stem	stem	NOUN
gs-3446	128	3	cells	cell	NOUN
gs-3446	128	4	,	,	PUNCT
gs-3446	128	5	for	for	ADP
gs-3446	128	6	instance	instance	NOUN
gs-3446	128	7	,	,	PUNCT
gs-3446	128	8	have	have	AUX
gs-3446	128	9	been	be	AUX
gs-3446	128	10	genetically	genetically	ADV
gs-3446	128	11	modified	modify	VERB
gs-3446	128	12	to	to	PART
gs-3446	128	13	treat	treat	VERB
gs-3446	128	14	genetic	genetic	ADJ
gs-3446	128	15	disorders	disorder	NOUN
gs-3446	128	16	such	such	ADJ
gs-3446	128	17	as	as	ADP
gs-3446	128	18	sickle	sickle	NOUN
gs-3446	128	19	cell	cell	NOUN
gs-3446	128	20	anemia	anemia	NOUN
gs-3446	128	21	and	and	CCONJ
gs-3446	128	22	beta	beta	NOUN
gs-3446	128	23	-	-	PUNCT
gs-3446	128	24	thalassemia	thalassemia	NOUN
gs-3446	128	25	.	.	PUNCT
gs-3446	129	1	stem	stem	NOUN
gs-3446	129	2	cells	cell	NOUN
gs-3446	129	3	are	be	AUX
gs-3446	129	4	being	be	AUX
gs-3446	129	5	genetically	genetically	ADV
gs-3446	129	6	optimized	optimize	VERB
gs-3446	129	7	to	to	PART
gs-3446	129	8	enhance	enhance	VERB
gs-3446	129	9	their	their	PRON
gs-3446	129	10	therapeutic	therapeutic	ADJ
gs-3446	129	11	potential	potential	NOUN
gs-3446	129	12	.	.	PUNCT
gs-3446	130	1	for	for	ADP
gs-3446	130	2	example	example	NOUN
gs-3446	130	3	,	,	PUNCT
gs-3446	130	4	mesenchymal	mesenchymal	ADJ
gs-3446	130	5	stem	stem	NOUN
gs-3446	130	6	cells	cell	NOUN
gs-3446	130	7	are	be	AUX
gs-3446	130	8	engineered	engineer	VERB
gs-3446	130	9	to	to	ADP
gs-3446	130	10	overexpress	overexpress	NOUN
gs-3446	130	11	anti	anti	ADJ
gs-3446	130	12	-	-	ADJ
gs-3446	130	13	inflammatory	inflammatory	ADJ
gs-3446	130	14	cytokines	cytokine	NOUN
gs-3446	130	15	,	,	PUNCT
gs-3446	130	16	improving	improve	VERB
gs-3446	130	17	outcomes	outcome	NOUN
gs-3446	130	18	in	in	ADP
gs-3446	130	19	inflammatory	inflammatory	ADJ
gs-3446	130	20	diseases	disease	NOUN
gs-3446	130	21	.	.	PUNCT
gs-3446	131	1	stem	stem	NOUN
gs-3446	131	2	cell	cell	NOUN
gs-3446	131	3	-	-	PUNCT
gs-3446	131	4	derived	derive	VERB
gs-3446	131	5	organoids	organoid	NOUN
gs-3446	131	6	,	,	PUNCT
gs-3446	131	7	combined	combine	VERB
gs-3446	131	8	with	with	ADP
gs-3446	131	9	genetic	genetic	ADJ
gs-3446	131	10	manipulation	manipulation	NOUN
gs-3446	131	11	,	,	PUNCT
gs-3446	131	12	offer	offer	VERB
gs-3446	131	13	platforms	platform	NOUN
gs-3446	131	14	for	for	ADP
gs-3446	131	15	high	high	ADJ
gs-3446	131	16	-	-	PUNCT
gs-3446	131	17	throughput	throughput	NOUN
gs-3446	131	18	drug	drug	NOUN
gs-3446	131	19	screening	screening	NOUN
gs-3446	131	20	and	and	CCONJ
gs-3446	131	21	personalized	personalized	ADJ
gs-3446	131	22	medicine	medicine	NOUN
gs-3446	131	23	.	.	PUNCT
gs-3446	132	1	organoids	organoid	NOUN
gs-3446	132	2	offer	offer	VERB
gs-3446	132	3	a	a	DET
gs-3446	132	4	valuable	valuable	ADJ
gs-3446	132	5	alternative	alternative	NOUN
gs-3446	132	6	to	to	ADP
gs-3446	132	7	traditional	traditional	ADJ
gs-3446	132	8	research	research	NOUN
gs-3446	132	9	methods	method	NOUN
gs-3446	132	10	,	,	PUNCT
gs-3446	132	11	including	include	VERB
gs-3446	132	12	animal	animal	NOUN
gs-3446	132	13	models	model	NOUN
gs-3446	132	14	,	,	PUNCT
gs-3446	132	15	primary	primary	ADJ
gs-3446	132	16	cell	cell	NOUN
gs-3446	132	17	cultures	culture	NOUN
gs-3446	132	18	,	,	PUNCT
gs-3446	132	19	and	and	CCONJ
gs-3446	132	20	cancer	cancer	NOUN
gs-3446	132	21	cell	cell	NOUN
gs-3446	132	22	lines	line	NOUN
gs-3446	132	23	.	.	PUNCT
gs-3446	133	1	recent	recent	ADJ
gs-3446	133	2	progress	progress	NOUN
gs-3446	133	3	in	in	ADP
gs-3446	133	4	gene	gene	NOUN
gs-3446	133	5	-	-	PUNCT
gs-3446	133	6	editing	edit	VERB
gs-3446	133	7	technologies	technology	NOUN
gs-3446	133	8	,	,	PUNCT
gs-3446	133	9	such	such	ADJ
gs-3446	133	10	as	as	ADP
gs-3446	133	11	crispr	crispr	NOUN
gs-3446	133	12	-	-	PUNCT
gs-3446	133	13	cas9	cas9	NOUN
gs-3446	133	14	,	,	PUNCT
gs-3446	133	15	along	along	ADP
gs-3446	133	16	with	with	ADP
gs-3446	133	17	prime	prime	ADJ
gs-3446	133	18	and	and	CCONJ
gs-3446	133	19	base	base	NOUN
gs-3446	133	20	-	-	PUNCT
gs-3446	133	21	editing	edit	VERB
gs-3446	133	22	tools	tool	NOUN
gs-3446	133	23	,	,	PUNCT
gs-3446	133	24	has	have	AUX
gs-3446	133	25	opened	open	VERB
gs-3446	133	26	new	new	ADJ
gs-3446	133	27	opportunities	opportunity	NOUN
gs-3446	133	28	for	for	ADP
gs-3446	133	29	investigating	investigate	VERB
gs-3446	133	30	complex	complex	ADJ
gs-3446	133	31	genetic	genetic	ADJ
gs-3446	133	32	diseases	disease	NOUN
gs-3446	133	33	.	.	PUNCT
gs-3446	134	1	as	as	SCONJ
gs-3446	134	2	innovations	innovation	NOUN
gs-3446	134	3	continue	continue	VERB
gs-3446	134	4	to	to	PART
gs-3446	134	5	reduce	reduce	VERB
gs-3446	134	6	the	the	DET
gs-3446	134	7	differences	difference	NOUN
gs-3446	134	8	between	between	ADP
gs-3446	134	9	organoids	organoid	NOUN
gs-3446	134	10	and	and	CCONJ
gs-3446	134	11	primary	primary	ADJ
gs-3446	134	12	tissues	tissue	NOUN
gs-3446	134	13	,	,	PUNCT
gs-3446	134	14	it	it	PRON
gs-3446	134	15	is	be	AUX
gs-3446	134	16	now	now	ADV
gs-3446	134	17	possible	possible	ADJ
gs-3446	134	18	to	to	PART
gs-3446	134	19	construct	construct	VERB
gs-3446	134	20	organoids	organoid	NOUN
gs-3446	134	21	and	and	CCONJ
gs-3446	134	22	organ	organ	NOUN
gs-3446	134	23	systems	system	NOUN
gs-3446	134	24	that	that	PRON
gs-3446	134	25	more	more	ADV
gs-3446	134	26	accurately	accurately	ADV
gs-3446	134	27	replicate	replicate	VERB
gs-3446	134	28	human	human	ADJ
gs-3446	134	29	organs	organ	NOUN
gs-3446	134	30	.	.	PUNCT
gs-3446	135	1	these	these	DET
gs-3446	135	2	models	model	NOUN
gs-3446	135	3	feature	feature	VERB
gs-3446	135	4	precisely	precisely	ADV
gs-3446	135	5	coordinated	coordinated	ADJ
gs-3446	135	6	cell	cell	NOUN
gs-3446	135	7	-	-	PUNCT
gs-3446	135	8	signaling	signal	VERB
gs-3446	135	9	networks	network	NOUN
gs-3446	135	10	,	,	PUNCT
gs-3446	135	11	improving	improve	VERB
gs-3446	135	12	their	their	PRON
gs-3446	135	13	ability	ability	NOUN
gs-3446	135	14	to	to	PART
gs-3446	135	15	respond	respond	VERB
gs-3446	135	16	to	to	ADP
gs-3446	135	17	non	non	ADJ
gs-3446	135	18	-	-	ADJ
gs-3446	135	19	genetic	genetic	ADJ
gs-3446	135	20	influences	influence	NOUN
gs-3446	135	21	such	such	ADJ
gs-3446	135	22	as	as	ADP
gs-3446	135	23	toxins	toxin	NOUN
gs-3446	135	24	,	,	PUNCT
gs-3446	135	25	chemicals	chemical	NOUN
gs-3446	135	26	,	,	PUNCT
gs-3446	135	27	and	and	CCONJ
gs-3446	135	28	metabolites	metabolite	NOUN
gs-3446	135	29	(	(	PUNCT
gs-3446	135	30	singh	singh	PROPN
gs-3446	135	31	et	et	PROPN
gs-3446	135	32	al	al	PROPN
gs-3446	135	33	.	.	PROPN
gs-3446	135	34	2015	2015	NUM
gs-3446	135	35	)	)	PUNCT
gs-3446	135	36	.	.	PUNCT
gs-3446	136	1	figure	figure	NOUN
gs-3446	136	2	2	2	NUM
gs-3446	136	3	.	.	NOUN
gs-3446	136	4	overview	overview	NOUN
gs-3446	136	5	of	of	ADP
gs-3446	136	6	stem	stem	NOUN
gs-3446	136	7	cell	cell	NOUN
gs-3446	136	8	systems	system	NOUN
gs-3446	136	9	across	across	ADP
gs-3446	136	10	potency	potency	NOUN
gs-3446	136	11	states	state	NOUN
gs-3446	136	12	and	and	CCONJ
gs-3446	136	13	regulatory	regulatory	ADJ
gs-3446	136	14	mechanisms	mechanism	NOUN
gs-3446	136	15	.	.	PUNCT
gs-3446	137	1	georgian	georgian	ADJ
gs-3446	137	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	137	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	137	4	ტ.	ტ.	VERB
gs-3446	137	5	7	7	NUM
gs-3446	137	6	n	n	PRON
gs-3446	137	7	1	1	NUM
gs-3446	137	8	,	,	PUNCT
gs-3446	137	9	2025	2025	NUM
gs-3446	137	10	280	280	NUM
gs-3446	137	11	this	this	DET
gs-3446	137	12	schematic	schematic	ADJ
gs-3446	137	13	illustrates	illustrate	VERB
gs-3446	137	14	the	the	DET
gs-3446	137	15	hierarchical	hierarchical	ADJ
gs-3446	137	16	organization	organization	NOUN
gs-3446	137	17	of	of	ADP
gs-3446	137	18	stem	stem	NOUN
gs-3446	137	19	cells	cell	NOUN
gs-3446	137	20	,	,	PUNCT
gs-3446	137	21	from	from	ADP
gs-3446	137	22	pluripotent	pluripotent	NOUN
gs-3446	137	23	to	to	ADP
gs-3446	137	24	multipotent	multipotent	NOUN
gs-3446	137	25	and	and	CCONJ
gs-3446	137	26	unipotent	unipotent	ADJ
gs-3446	137	27	states	state	NOUN
gs-3446	137	28	,	,	PUNCT
gs-3446	137	29	highlighting	highlight	VERB
gs-3446	137	30	dynamic	dynamic	ADJ
gs-3446	137	31	transcriptional	transcriptional	ADJ
gs-3446	137	32	circuits	circuit	NOUN
gs-3446	137	33	governed	govern	VERB
gs-3446	137	34	by	by	ADP
gs-3446	137	35	core	core	NOUN
gs-3446	137	36	factors	factor	NOUN
gs-3446	137	37	(	(	PUNCT
gs-3446	137	38	oct4	oct4	PROPN
gs-3446	137	39	,	,	PUNCT
gs-3446	137	40	sox2	sox2	NOUN
gs-3446	137	41	,	,	PUNCT
gs-3446	137	42	nanog	nanog	PROPN
gs-3446	137	43	)	)	PUNCT
gs-3446	137	44	and	and	CCONJ
gs-3446	137	45	signaling	signal	VERB
gs-3446	137	46	pathways	pathway	NOUN
gs-3446	137	47	(	(	PUNCT
gs-3446	137	48	wnt	wnt	PROPN
gs-3446	137	49	/	/	SYM
gs-3446	137	50	β	β	NOUN
gs-3446	137	51	-	-	ADJ
gs-3446	137	52	catenin	catenin	ADJ
gs-3446	137	53	,	,	PUNCT
gs-3446	137	54	notch	notch	NOUN
gs-3446	137	55	,	,	PUNCT
gs-3446	137	56	hedgehog	hedgehog	NOUN
gs-3446	137	57	)	)	PUNCT
gs-3446	137	58	.	.	PUNCT
gs-3446	138	1	stem	stem	NOUN
gs-3446	138	2	cell	cell	NOUN
gs-3446	138	3	niches	niche	NOUN
gs-3446	138	4	provide	provide	VERB
gs-3446	138	5	critical	critical	ADJ
gs-3446	138	6	extrinsic	extrinsic	ADJ
gs-3446	138	7	cues	cue	NOUN
gs-3446	138	8	,	,	PUNCT
gs-3446	138	9	while	while	SCONJ
gs-3446	138	10	intrinsic	intrinsic	ADJ
gs-3446	138	11	regulators	regulator	NOUN
gs-3446	138	12	,	,	PUNCT
gs-3446	138	13	including	include	VERB
gs-3446	138	14	epigenetic	epigenetic	ADJ
gs-3446	138	15	and	and	CCONJ
gs-3446	138	16	metabolic	metabolic	NOUN
gs-3446	138	17	factors	factor	NOUN
gs-3446	138	18	,	,	PUNCT
gs-3446	138	19	maintain	maintain	VERB
gs-3446	138	20	homeostasis	homeostasis	NOUN
gs-3446	138	21	.	.	PUNCT
gs-3446	139	1	applications	application	NOUN
gs-3446	139	2	such	such	ADJ
gs-3446	139	3	as	as	ADP
gs-3446	139	4	tissue	tissue	NOUN
gs-3446	139	5	engineering	engineering	NOUN
gs-3446	139	6	,	,	PUNCT
gs-3446	139	7	genome	genome	NOUN
gs-3446	139	8	editing	editing	NOUN
gs-3446	139	9	(	(	PUNCT
gs-3446	139	10	crispr	crispr	NOUN
gs-3446	139	11	-	-	PUNCT
gs-3446	139	12	cas9	cas9	NOUN
gs-3446	139	13	)	)	PUNCT
gs-3446	139	14	,	,	PUNCT
gs-3446	139	15	and	and	CCONJ
gs-3446	139	16	regenerative	regenerative	ADJ
gs-3446	139	17	therapies	therapy	NOUN
gs-3446	139	18	are	be	AUX
gs-3446	139	19	shown	show	VERB
gs-3446	139	20	alongside	alongside	ADP
gs-3446	139	21	processes	process	NOUN
gs-3446	139	22	affecting	affect	VERB
gs-3446	139	23	stem	stem	NOUN
gs-3446	139	24	cell	cell	NOUN
gs-3446	139	25	function	function	NOUN
gs-3446	139	26	,	,	PUNCT
gs-3446	139	27	including	include	VERB
gs-3446	139	28	aging	age	VERB
gs-3446	139	29	-	-	PUNCT
gs-3446	139	30	related	relate	VERB
gs-3446	139	31	decline	decline	NOUN
gs-3446	139	32	and	and	CCONJ
gs-3446	139	33	cancer	cancer	NOUN
gs-3446	139	34	stem	stem	NOUN
gs-3446	139	35	cell	cell	NOUN
gs-3446	139	36	dysregulation	dysregulation	NOUN
gs-3446	139	37	.	.	PUNCT
gs-3446	140	1	while	while	SCONJ
gs-3446	140	2	the	the	DET
gs-3446	140	3	potential	potential	NOUN
gs-3446	140	4	of	of	ADP
gs-3446	140	5	stem	stem	NOUN
gs-3446	140	6	cells	cell	NOUN
gs-3446	140	7	and	and	CCONJ
gs-3446	140	8	genetics	genetic	NOUN
gs-3446	140	9	is	be	AUX
gs-3446	140	10	immense	immense	ADJ
gs-3446	140	11	,	,	PUNCT
gs-3446	140	12	challenges	challenge	NOUN
gs-3446	140	13	remain	remain	VERB
gs-3446	140	14	.	.	PUNCT
gs-3446	141	1	ethical	ethical	ADJ
gs-3446	141	2	concerns	concern	NOUN
gs-3446	141	3	include	include	VERB
gs-3446	141	4	the	the	DET
gs-3446	141	5	use	use	NOUN
gs-3446	141	6	of	of	ADP
gs-3446	141	7	embryonic	embryonic	ADJ
gs-3446	141	8	stem	stem	NOUN
gs-3446	141	9	cells	cell	NOUN
gs-3446	141	10	and	and	CCONJ
gs-3446	141	11	the	the	DET
gs-3446	141	12	societal	societal	ADJ
gs-3446	141	13	and	and	CCONJ
gs-3446	141	14	moral	moral	ADJ
gs-3446	141	15	dilemmas	dilemma	NOUN
gs-3446	141	16	posed	pose	VERB
gs-3446	141	17	by	by	ADP
gs-3446	141	18	genetic	genetic	ADJ
gs-3446	141	19	modifications	modification	NOUN
gs-3446	141	20	,	,	PUNCT
gs-3446	141	21	particularly	particularly	ADV
gs-3446	141	22	germline	germline	VERB
gs-3446	141	23	editing	edit	VERB
gs-3446	141	24	.	.	PUNCT
gs-3446	142	1	technical	technical	ADJ
gs-3446	142	2	hurdles	hurdle	NOUN
gs-3446	142	3	such	such	ADJ
gs-3446	142	4	as	as	ADP
gs-3446	142	5	off	off	ADP
gs-3446	142	6	-	-	PUNCT
gs-3446	142	7	target	target	NOUN
gs-3446	142	8	effects	effect	NOUN
gs-3446	142	9	in	in	ADP
gs-3446	142	10	genome	genome	NOUN
gs-3446	142	11	editing	editing	NOUN
gs-3446	142	12	,	,	PUNCT
gs-3446	142	13	inefficient	inefficient	ADJ
gs-3446	142	14	reprogramming	reprogramming	NOUN
gs-3446	142	15	,	,	PUNCT
gs-3446	142	16	and	and	CCONJ
gs-3446	142	17	immune	immune	ADJ
gs-3446	142	18	rejection	rejection	NOUN
gs-3446	142	19	of	of	ADP
gs-3446	142	20	transplanted	transplanted	ADJ
gs-3446	142	21	cells	cell	NOUN
gs-3446	142	22	need	need	VERB
gs-3446	142	23	to	to	PART
gs-3446	142	24	be	be	AUX
gs-3446	142	25	addressed	address	VERB
gs-3446	142	26	.	.	PUNCT
gs-3446	143	1	the	the	DET
gs-3446	143	2	rapid	rapid	ADJ
gs-3446	143	3	pace	pace	NOUN
gs-3446	143	4	of	of	ADP
gs-3446	143	5	advancements	advancement	NOUN
gs-3446	143	6	necessitates	necessitate	VERB
gs-3446	143	7	updated	update	VERB
gs-3446	143	8	regulatory	regulatory	ADJ
gs-3446	143	9	guidelines	guideline	NOUN
gs-3446	143	10	to	to	PART
gs-3446	143	11	ensure	ensure	VERB
gs-3446	143	12	the	the	DET
gs-3446	143	13	safety	safety	NOUN
gs-3446	143	14	and	and	CCONJ
gs-3446	143	15	efficacy	efficacy	NOUN
gs-3446	143	16	of	of	ADP
gs-3446	143	17	stem	stem	NOUN
gs-3446	143	18	cellbased	cellbase	VERB
gs-3446	143	19	therapies	therapy	NOUN
gs-3446	143	20	(	(	PUNCT
gs-3446	143	21	halpern	halpern	PROPN
gs-3446	143	22	et	et	PROPN
gs-3446	143	23	al	al	PROPN
gs-3446	143	24	.	.	PROPN
gs-3446	143	25	2019	2019	NUM
gs-3446	143	26	)	)	PUNCT
gs-3446	143	27	.	.	PUNCT
gs-3446	144	1	stem	stem	NOUN
gs-3446	144	2	cells	cell	NOUN
gs-3446	144	3	markers	marker	NOUN
gs-3446	144	4	stem	stem	NOUN
gs-3446	144	5	cell	cell	NOUN
gs-3446	144	6	markers	marker	NOUN
gs-3446	144	7	are	be	AUX
gs-3446	144	8	specific	specific	ADJ
gs-3446	144	9	molecules	molecule	NOUN
gs-3446	144	10	,	,	PUNCT
gs-3446	144	11	often	often	ADV
gs-3446	144	12	proteins	protein	NOUN
gs-3446	144	13	,	,	PUNCT
gs-3446	144	14	that	that	PRON
gs-3446	144	15	are	be	AUX
gs-3446	144	16	expressed	express	VERB
gs-3446	144	17	on	on	ADP
gs-3446	144	18	the	the	DET
gs-3446	144	19	surface	surface	NOUN
gs-3446	144	20	or	or	CCONJ
gs-3446	144	21	within	within	ADP
gs-3446	144	22	stem	stem	NOUN
gs-3446	144	23	cells	cell	NOUN
gs-3446	144	24	and	and	CCONJ
gs-3446	144	25	are	be	AUX
gs-3446	144	26	used	use	VERB
gs-3446	144	27	to	to	PART
gs-3446	144	28	identify	identify	VERB
gs-3446	144	29	and	and	CCONJ
gs-3446	144	30	isolate	isolate	VERB
gs-3446	144	31	these	these	DET
gs-3446	144	32	cells	cell	NOUN
gs-3446	144	33	from	from	ADP
gs-3446	144	34	heterogeneous	heterogeneous	ADJ
gs-3446	144	35	populations	population	NOUN
gs-3446	144	36	.	.	PUNCT
gs-3446	145	1	these	these	DET
gs-3446	145	2	markers	marker	NOUN
gs-3446	145	3	play	play	VERB
gs-3446	145	4	a	a	DET
gs-3446	145	5	crucial	crucial	ADJ
gs-3446	145	6	role	role	NOUN
gs-3446	145	7	in	in	ADP
gs-3446	145	8	stem	stem	NOUN
gs-3446	145	9	cell	cell	NOUN
gs-3446	145	10	research	research	NOUN
gs-3446	145	11	,	,	PUNCT
gs-3446	145	12	enabling	enable	VERB
gs-3446	145	13	scientists	scientist	NOUN
gs-3446	145	14	to	to	PART
gs-3446	145	15	characterize	characterize	VERB
gs-3446	145	16	,	,	PUNCT
gs-3446	145	17	sort	sort	NOUN
gs-3446	145	18	,	,	PUNCT
gs-3446	145	19	and	and	CCONJ
gs-3446	145	20	study	study	NOUN
gs-3446	145	21	stem	stem	NOUN
gs-3446	145	22	cells	cell	NOUN
gs-3446	145	23	in	in	ADP
gs-3446	145	24	various	various	ADJ
gs-3446	145	25	contexts	contexts	NOUN
gs-3446	145	26	,	,	PUNCT
gs-3446	145	27	including	include	VERB
gs-3446	145	28	development	development	NOUN
gs-3446	145	29	,	,	PUNCT
gs-3446	145	30	regeneration	regeneration	NOUN
gs-3446	145	31	,	,	PUNCT
gs-3446	145	32	and	and	CCONJ
gs-3446	145	33	disease	disease	NOUN
gs-3446	145	34	.	.	PUNCT
gs-3446	146	1	the	the	DET
gs-3446	146	2	expression	expression	NOUN
gs-3446	146	3	of	of	ADP
gs-3446	146	4	these	these	DET
gs-3446	146	5	markers	marker	NOUN
gs-3446	146	6	can	can	AUX
gs-3446	146	7	vary	vary	VERB
gs-3446	146	8	depending	depend	VERB
gs-3446	146	9	on	on	ADP
gs-3446	146	10	the	the	DET
gs-3446	146	11	type	type	NOUN
gs-3446	146	12	of	of	ADP
gs-3446	146	13	stem	stem	NOUN
gs-3446	146	14	cell	cell	NOUN
gs-3446	146	15	,	,	PUNCT
gs-3446	146	16	its	its	PRON
gs-3446	146	17	potency	potency	NOUN
gs-3446	146	18	,	,	PUNCT
gs-3446	146	19	and	and	CCONJ
gs-3446	146	20	its	its	PRON
gs-3446	146	21	differentiation	differentiation	NOUN
gs-3446	146	22	state	state	NOUN
gs-3446	146	23	.	.	PUNCT
gs-3446	147	1	key	key	ADJ
gs-3446	147	2	stem	stem	NOUN
gs-3446	147	3	cell	cell	NOUN
gs-3446	147	4	markers	marker	NOUN
gs-3446	147	5	1	1	NUM
gs-3446	147	6	.	.	PUNCT
gs-3446	148	1	pluripotent	pluripotent	ADJ
gs-3446	148	2	stem	stem	NOUN
gs-3446	148	3	cell	cell	NOUN
gs-3446	148	4	markers	marker	NOUN
gs-3446	148	5	:	:	PUNCT
gs-3446	148	6	○	○	ADJ
gs-3446	148	7	oct4	oct4	PROPN
gs-3446	148	8	(	(	PUNCT
gs-3446	148	9	pou5f1	pou5f1	PROPN
gs-3446	148	10	):	):	PUNCT
gs-3446	148	11	a	a	DET
gs-3446	148	12	transcription	transcription	NOUN
gs-3446	148	13	factor	factor	NOUN
gs-3446	148	14	essential	essential	ADJ
gs-3446	148	15	for	for	ADP
gs-3446	148	16	maintaining	maintain	VERB
gs-3446	148	17	the	the	DET
gs-3446	148	18	pluripotency	pluripotency	NOUN
gs-3446	148	19	of	of	ADP
gs-3446	148	20	embryonic	embryonic	ADJ
gs-3446	148	21	stem	stem	NOUN
gs-3446	148	22	cells	cell	NOUN
gs-3446	148	23	(	(	PUNCT
gs-3446	148	24	escs	esc	NOUN
gs-3446	148	25	)	)	PUNCT
gs-3446	148	26	and	and	CCONJ
gs-3446	148	27	induced	induce	VERB
gs-3446	148	28	pluripotent	pluripotent	ADJ
gs-3446	148	29	stem	stem	NOUN
gs-3446	148	30	cells	cell	NOUN
gs-3446	148	31	(	(	PUNCT
gs-3446	148	32	ipscs	ipscs	NOUN
gs-3446	148	33	)	)	PUNCT
gs-3446	148	34	.	.	PUNCT
gs-3446	149	1	oct4	oct4	PROPN
gs-3446	149	2	works	work	VERB
gs-3446	149	3	in	in	ADP
gs-3446	149	4	conjunction	conjunction	NOUN
gs-3446	149	5	with	with	ADP
gs-3446	149	6	sox2	sox2	NOUN
gs-3446	149	7	and	and	CCONJ
gs-3446	149	8	nanog	nanog	PROPN
gs-3446	149	9	to	to	PART
gs-3446	149	10	sustain	sustain	VERB
gs-3446	149	11	the	the	DET
gs-3446	149	12	undifferentiated	undifferentiated	ADJ
gs-3446	149	13	state	state	NOUN
gs-3446	149	14	.	.	PUNCT
gs-3446	150	1	○	○	ADJ
gs-3446	150	2	sox2	sox2	PROPN
gs-3446	150	3	:	:	PUNCT
gs-3446	150	4	another	another	DET
gs-3446	150	5	critical	critical	ADJ
gs-3446	150	6	transcription	transcription	NOUN
gs-3446	150	7	factor	factor	NOUN
gs-3446	150	8	that	that	PRON
gs-3446	150	9	,	,	PUNCT
gs-3446	150	10	along	along	ADP
gs-3446	150	11	with	with	ADP
gs-3446	150	12	oct4	oct4	PROPN
gs-3446	150	13	and	and	CCONJ
gs-3446	150	14	nanog	nanog	PROPN
gs-3446	150	15	,	,	PUNCT
gs-3446	150	16	forms	form	VERB
gs-3446	150	17	the	the	DET
gs-3446	150	18	core	core	ADJ
gs-3446	150	19	regulatory	regulatory	ADJ
gs-3446	150	20	network	network	NOUN
gs-3446	150	21	for	for	ADP
gs-3446	150	22	pluripotency	pluripotency	NOUN
gs-3446	150	23	.	.	PUNCT
gs-3446	151	1	sox2	sox2	NOUN
gs-3446	151	2	is	be	AUX
gs-3446	151	3	also	also	ADV
gs-3446	151	4	involved	involve	VERB
gs-3446	151	5	in	in	ADP
gs-3446	151	6	maintaining	maintain	VERB
gs-3446	151	7	the	the	DET
gs-3446	151	8	self	self	NOUN
gs-3446	151	9	-	-	PUNCT
gs-3446	151	10	renewal	renewal	NOUN
gs-3446	151	11	capacity	capacity	NOUN
gs-3446	151	12	of	of	ADP
gs-3446	151	13	stem	stem	NOUN
gs-3446	151	14	cells	cell	NOUN
gs-3446	151	15	.	.	PUNCT
gs-3446	152	1	○	○	PROPN
gs-3446	152	2	nanog	nanog	PROPN
gs-3446	152	3	:	:	PUNCT
gs-3446	152	4	a	a	DET
gs-3446	152	5	key	key	ADJ
gs-3446	152	6	pluripotency	pluripotency	NOUN
gs-3446	152	7	marker	marker	NOUN
gs-3446	152	8	that	that	PRON
gs-3446	152	9	prevents	prevent	VERB
gs-3446	152	10	differentiation	differentiation	NOUN
gs-3446	152	11	and	and	CCONJ
gs-3446	152	12	maintains	maintain	VERB
gs-3446	152	13	the	the	DET
gs-3446	152	14	stem	stem	NOUN
gs-3446	152	15	cell	cell	NOUN
gs-3446	152	16	state	state	NOUN
gs-3446	152	17	.	.	PUNCT
gs-3446	153	1	nanog	nanog	PROPN
gs-3446	153	2	expression	expression	NOUN
gs-3446	153	3	is	be	AUX
gs-3446	153	4	tightly	tightly	ADV
gs-3446	153	5	regulated	regulate	VERB
gs-3446	153	6	and	and	CCONJ
gs-3446	153	7	is	be	AUX
gs-3446	153	8	often	often	ADV
gs-3446	153	9	used	use	VERB
gs-3446	153	10	to	to	PART
gs-3446	153	11	identify	identify	VERB
gs-3446	153	12	pluripotent	pluripotent	ADJ
gs-3446	153	13	stem	stem	NOUN
gs-3446	153	14	cells	cell	NOUN
gs-3446	153	15	.	.	PUNCT
gs-3446	154	1	○	○	PROPN
gs-3446	154	2	ssea-3/4	ssea-3/4	PROPN
gs-3446	154	3	(	(	PUNCT
gs-3446	154	4	stage	stage	NOUN
gs-3446	154	5	-	-	PUNCT
gs-3446	154	6	specific	specific	ADJ
gs-3446	154	7	embryonic	embryonic	ADJ
gs-3446	154	8	antigen	antigen	NOUN
gs-3446	154	9	3/4	3/4	NUM
gs-3446	154	10	):	):	PUNCT
gs-3446	154	11	cell	cell	NOUN
gs-3446	154	12	surface	surface	NOUN
gs-3446	154	13	glycolipids	glycolipid	NOUN
gs-3446	154	14	expressed	express	VERB
gs-3446	154	15	on	on	ADP
gs-3446	154	16	human	human	ADJ
gs-3446	154	17	escs	esc	NOUN
gs-3446	154	18	and	and	CCONJ
gs-3446	154	19	ipscs	ipsc	NOUN
gs-3446	154	20	.	.	PUNCT
gs-3446	155	1	these	these	DET
gs-3446	155	2	markers	marker	NOUN
gs-3446	155	3	are	be	AUX
gs-3446	155	4	commonly	commonly	ADV
gs-3446	155	5	used	use	VERB
gs-3446	155	6	in	in	ADP
gs-3446	155	7	flow	flow	NOUN
gs-3446	155	8	cytometry	cytometry	NOUN
gs-3446	155	9	and	and	CCONJ
gs-3446	155	10	immunocytochemistry	immunocytochemistry	NOUN
gs-3446	155	11	to	to	PART
gs-3446	155	12	identify	identify	VERB
gs-3446	155	13	pluripotent	pluripotent	ADJ
gs-3446	155	14	stem	stem	NOUN
gs-3446	155	15	cells	cell	NOUN
gs-3446	155	16	.	.	PUNCT
gs-3446	156	1	○	○	PROPN
gs-3446	156	2	tra-1	tra-1	NUM
gs-3446	156	3	-	-	PUNCT
gs-3446	156	4	60	60	NUM
gs-3446	156	5	/	/	SYM
gs-3446	156	6	tra-1	tra-1	NOUN
gs-3446	156	7	-	-	PUNCT
gs-3446	156	8	81	81	NUM
gs-3446	156	9	:	:	PUNCT
gs-3446	156	10	cell	cell	NOUN
gs-3446	156	11	surface	surface	NOUN
gs-3446	156	12	antigens	antigen	NOUN
gs-3446	156	13	expressed	express	VERB
gs-3446	156	14	on	on	ADP
gs-3446	156	15	human	human	ADJ
gs-3446	156	16	pluripotent	pluripotent	ADJ
gs-3446	156	17	stem	stem	NOUN
gs-3446	156	18	cells	cell	NOUN
gs-3446	156	19	,	,	PUNCT
gs-3446	156	20	often	often	ADV
gs-3446	156	21	used	use	VERB
gs-3446	156	22	in	in	ADP
gs-3446	156	23	conjunction	conjunction	NOUN
gs-3446	156	24	with	with	ADP
gs-3446	156	25	ssea-4	ssea-4	NUM
gs-3446	156	26	for	for	ADP
gs-3446	156	27	identification	identification	NOUN
gs-3446	156	28	and	and	CCONJ
gs-3446	156	29	sorting	sort	VERB
gs-3446	156	30	(	(	PUNCT
gs-3446	156	31	boyer	boyer	PROPN
gs-3446	156	32	et	et	PROPN
gs-3446	156	33	al	al	PROPN
gs-3446	156	34	.	.	PROPN
gs-3446	156	35	2005	2005	NUM
gs-3446	156	36	)	)	PUNCT
gs-3446	156	37	.	.	PUNCT
gs-3446	157	1	georgian	georgian	ADJ
gs-3446	157	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	157	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	157	4	ტ.	ტ.	VERB
gs-3446	157	5	7	7	NUM
gs-3446	157	6	n	n	DET
gs-3446	157	7	1	1	NUM
gs-3446	157	8	,	,	PUNCT
gs-3446	157	9	2025	2025	NUM
gs-3446	157	10	281	281	NUM
gs-3446	157	11	2	2	NUM
gs-3446	157	12	.	.	PUNCT
gs-3446	157	13	mesenchymal	mesenchymal	ADJ
gs-3446	157	14	stem	stem	NOUN
gs-3446	157	15	cell	cell	NOUN
gs-3446	157	16	(	(	PUNCT
gs-3446	157	17	msc	msc	NOUN
gs-3446	157	18	)	)	PUNCT
gs-3446	157	19	markers	marker	NOUN
gs-3446	157	20	:	:	PUNCT
gs-3446	157	21	○	○	PROPN
gs-3446	157	22	cd73	cd73	PROPN
gs-3446	157	23	(	(	PUNCT
gs-3446	157	24	nt5e	nt5e	PROPN
gs-3446	157	25	):	):	PUNCT
gs-3446	157	26	a	a	DET
gs-3446	157	27	surface	surface	NOUN
gs-3446	157	28	enzyme	enzyme	NOUN
gs-3446	157	29	involved	involve	VERB
gs-3446	157	30	in	in	ADP
gs-3446	157	31	purine	purine	NOUN
gs-3446	157	32	metabolism	metabolism	NOUN
gs-3446	157	33	,	,	PUNCT
gs-3446	157	34	commonly	commonly	ADV
gs-3446	157	35	expressed	express	VERB
gs-3446	157	36	on	on	ADP
gs-3446	157	37	mscs	msc	NOUN
gs-3446	157	38	.	.	PUNCT
gs-3446	158	1	○	○	PROPN
gs-3446	158	2	cd90	cd90	PROPN
gs-3446	158	3	(	(	PUNCT
gs-3446	158	4	thy-1	thy-1	NUM
gs-3446	158	5	):	):	PUNCT
gs-3446	158	6	a	a	DET
gs-3446	158	7	glycophosphatidylinositol	glycophosphatidylinositol	NOUN
gs-3446	158	8	(	(	PUNCT
gs-3446	158	9	gpi)-anchored	gpi)-anchored	ADJ
gs-3446	158	10	protein	protein	NOUN
gs-3446	158	11	expressed	express	VERB
gs-3446	158	12	on	on	ADP
gs-3446	158	13	the	the	DET
gs-3446	158	14	surface	surface	NOUN
gs-3446	158	15	of	of	ADP
gs-3446	158	16	mscs	msc	NOUN
gs-3446	158	17	,	,	PUNCT
gs-3446	158	18	fibroblasts	fibroblast	NOUN
gs-3446	158	19	,	,	PUNCT
gs-3446	158	20	and	and	CCONJ
gs-3446	158	21	some	some	DET
gs-3446	158	22	hematopoietic	hematopoietic	ADJ
gs-3446	158	23	cells	cell	NOUN
gs-3446	158	24	.	.	PUNCT
gs-3446	159	1	○	○	PROPN
gs-3446	159	2	cd105	cd105	PROPN
gs-3446	159	3	(	(	PUNCT
gs-3446	159	4	endoglin	endoglin	PROPN
gs-3446	159	5	):	):	PUNCT
gs-3446	159	6	a	a	DET
gs-3446	159	7	component	component	NOUN
gs-3446	159	8	of	of	ADP
gs-3446	159	9	the	the	DET
gs-3446	159	10	tgf	tgf	PROPN
gs-3446	159	11	-	-	PUNCT
gs-3446	159	12	β	β	PROPN
gs-3446	159	13	receptor	receptor	NOUN
gs-3446	159	14	complex	complex	NOUN
gs-3446	159	15	,	,	PUNCT
gs-3446	159	16	expressed	express	VERB
gs-3446	159	17	on	on	ADP
gs-3446	159	18	mscs	msc	NOUN
gs-3446	159	19	and	and	CCONJ
gs-3446	159	20	endothelial	endothelial	ADJ
gs-3446	159	21	cells	cell	NOUN
gs-3446	159	22	.	.	PUNCT
gs-3446	160	1	○	○	PROPN
gs-3446	160	2	cd44	cd44	PROPN
gs-3446	160	3	:	:	PUNCT
gs-3446	160	4	a	a	DET
gs-3446	160	5	cell	cell	NOUN
gs-3446	160	6	surface	surface	NOUN
gs-3446	160	7	glycoprotein	glycoprotein	NOUN
gs-3446	160	8	involved	involve	VERB
gs-3446	160	9	in	in	ADP
gs-3446	160	10	cell	cell	NOUN
gs-3446	160	11	-	-	PUNCT
gs-3446	160	12	cell	cell	NOUN
gs-3446	160	13	interactions	interaction	NOUN
gs-3446	160	14	,	,	PUNCT
gs-3446	160	15	adhesion	adhesion	NOUN
gs-3446	160	16	,	,	PUNCT
gs-3446	160	17	and	and	CCONJ
gs-3446	160	18	migration	migration	NOUN
gs-3446	160	19	.	.	PUNCT
gs-3446	161	1	it	it	PRON
gs-3446	161	2	is	be	AUX
gs-3446	161	3	widely	widely	ADV
gs-3446	161	4	expressed	express	VERB
gs-3446	161	5	on	on	ADP
gs-3446	161	6	mscs	msc	NOUN
gs-3446	161	7	and	and	CCONJ
gs-3446	161	8	cancer	cancer	NOUN
gs-3446	161	9	stem	stem	NOUN
gs-3446	161	10	cells	cell	NOUN
gs-3446	161	11	.	.	PUNCT
gs-3446	162	1	○	○	PROPN
gs-3446	162	2	stro-1	stro-1	PROPN
gs-3446	162	3	:	:	PUNCT
gs-3446	162	4	a	a	DET
gs-3446	162	5	cell	cell	NOUN
gs-3446	162	6	surface	surface	NOUN
gs-3446	162	7	antigen	antigen	NOUN
gs-3446	162	8	used	use	VERB
gs-3446	162	9	to	to	PART
gs-3446	162	10	identify	identify	VERB
gs-3446	162	11	and	and	CCONJ
gs-3446	162	12	isolate	isolate	VERB
gs-3446	162	13	mscs	msc	NOUN
gs-3446	162	14	from	from	ADP
gs-3446	162	15	bone	bone	NOUN
gs-3446	162	16	marrow	marrow	NOUN
gs-3446	162	17	.	.	PUNCT
gs-3446	163	1	3	3	X
gs-3446	163	2	.	.	X
gs-3446	163	3	hematopoietic	hematopoietic	ADJ
gs-3446	163	4	stem	stem	NOUN
gs-3446	163	5	cell	cell	NOUN
gs-3446	163	6	(	(	PUNCT
gs-3446	163	7	hsc	hsc	NOUN
gs-3446	163	8	)	)	PUNCT
gs-3446	163	9	markers	marker	NOUN
gs-3446	163	10	:	:	PUNCT
gs-3446	163	11	○	○	PROPN
gs-3446	163	12	cd34	cd34	PROPN
gs-3446	163	13	:	:	PUNCT
gs-3446	163	14	a	a	DET
gs-3446	163	15	cell	cell	NOUN
gs-3446	163	16	surface	surface	NOUN
gs-3446	163	17	glycoprotein	glycoprotein	NOUN
gs-3446	163	18	expressed	express	VERB
gs-3446	163	19	on	on	ADP
gs-3446	163	20	early	early	ADJ
gs-3446	163	21	hematopoietic	hematopoietic	ADJ
gs-3446	163	22	and	and	CCONJ
gs-3446	163	23	vascularassociated	vascularassociate	VERB
gs-3446	163	24	cells	cell	NOUN
gs-3446	163	25	.	.	PUNCT
gs-3446	164	1	cd34	cd34	PROPN
gs-3446	164	2	is	be	AUX
gs-3446	164	3	a	a	DET
gs-3446	164	4	well	well	ADV
gs-3446	164	5	-	-	PUNCT
gs-3446	164	6	known	know	VERB
gs-3446	164	7	marker	marker	NOUN
gs-3446	164	8	for	for	ADP
gs-3446	164	9	hscs	hsc	NOUN
gs-3446	164	10	and	and	CCONJ
gs-3446	164	11	progenitor	progenitor	NOUN
gs-3446	164	12	cells	cell	NOUN
gs-3446	164	13	.	.	PUNCT
gs-3446	165	1	○	○	PROPN
gs-3446	165	2	cd133	cd133	PROPN
gs-3446	165	3	(	(	PUNCT
gs-3446	165	4	prominin-1	prominin-1	NUM
gs-3446	165	5	):	):	PUNCT
gs-3446	165	6	a	a	DET
gs-3446	165	7	transmembrane	transmembrane	NOUN
gs-3446	165	8	glycoprotein	glycoprotein	NOUN
gs-3446	165	9	expressed	express	VERB
gs-3446	165	10	on	on	ADP
gs-3446	165	11	hematopoietic	hematopoietic	ADJ
gs-3446	165	12	stem	stem	NOUN
gs-3446	165	13	and	and	CCONJ
gs-3446	165	14	progenitor	progenitor	NOUN
gs-3446	165	15	cells	cell	NOUN
gs-3446	165	16	,	,	PUNCT
gs-3446	165	17	as	as	ADV
gs-3446	165	18	well	well	ADV
gs-3446	165	19	as	as	ADP
gs-3446	165	20	on	on	ADP
gs-3446	165	21	cancer	cancer	NOUN
gs-3446	165	22	stem	stem	NOUN
gs-3446	165	23	cells	cell	NOUN
gs-3446	165	24	.	.	PUNCT
gs-3446	166	1	○	○	PROPN
gs-3446	166	2	cd45	cd45	PROPN
gs-3446	166	3	(	(	PUNCT
gs-3446	166	4	leukocyte	leukocyte	NOUN
gs-3446	166	5	common	common	ADJ
gs-3446	166	6	antigen	antigen	NOUN
gs-3446	166	7	):	):	PUNCT
gs-3446	166	8	a	a	DET
gs-3446	166	9	tyrosine	tyrosine	NOUN
gs-3446	166	10	phosphatase	phosphatase	NOUN
gs-3446	166	11	expressed	express	VERB
gs-3446	166	12	on	on	ADP
gs-3446	166	13	all	all	DET
gs-3446	166	14	nucleated	nucleated	ADJ
gs-3446	166	15	hematopoietic	hematopoietic	ADJ
gs-3446	166	16	cells	cell	NOUN
gs-3446	166	17	,	,	PUNCT
gs-3446	166	18	often	often	ADV
gs-3446	166	19	used	use	VERB
gs-3446	166	20	in	in	ADP
gs-3446	166	21	combination	combination	NOUN
gs-3446	166	22	with	with	ADP
gs-3446	166	23	other	other	ADJ
gs-3446	166	24	markers	marker	NOUN
gs-3446	166	25	to	to	PART
gs-3446	166	26	identify	identify	VERB
gs-3446	166	27	hscs	hsc	NOUN
gs-3446	166	28	.	.	PUNCT
gs-3446	167	1	○	○	PROPN
gs-3446	167	2	c	c	NOUN
gs-3446	167	3	-	-	PUNCT
gs-3446	167	4	kit	kit	NOUN
gs-3446	167	5	(	(	PUNCT
gs-3446	167	6	cd117	cd117	PROPN
gs-3446	167	7	):	):	PUNCT
gs-3446	167	8	a	a	DET
gs-3446	167	9	receptor	receptor	NOUN
gs-3446	167	10	for	for	ADP
gs-3446	167	11	stem	stem	NOUN
gs-3446	167	12	cell	cell	NOUN
gs-3446	167	13	factor	factor	NOUN
gs-3446	167	14	(	(	PUNCT
gs-3446	167	15	scf	scf	PROPN
gs-3446	167	16	)	)	PUNCT
gs-3446	167	17	,	,	PUNCT
gs-3446	167	18	expressed	express	VERB
gs-3446	167	19	on	on	ADP
gs-3446	167	20	hscs	hsc	NOUN
gs-3446	167	21	and	and	CCONJ
gs-3446	167	22	other	other	ADJ
gs-3446	167	23	progenitor	progenitor	NOUN
gs-3446	167	24	cells	cell	NOUN
gs-3446	167	25	.	.	PUNCT
gs-3446	168	1	4	4	X
gs-3446	168	2	.	.	X
gs-3446	168	3	neural	neural	ADJ
gs-3446	168	4	stem	stem	NOUN
gs-3446	168	5	cell	cell	NOUN
gs-3446	168	6	(	(	PUNCT
gs-3446	168	7	nsc	nsc	PROPN
gs-3446	168	8	)	)	PUNCT
gs-3446	168	9	markers	marker	NOUN
gs-3446	168	10	:	:	PUNCT
gs-3446	168	11	○	○	PROPN
gs-3446	168	12	nestin	nestin	PROPN
gs-3446	168	13	:	:	PUNCT
gs-3446	168	14	an	an	DET
gs-3446	168	15	intermediate	intermediate	ADJ
gs-3446	168	16	filament	filament	NOUN
gs-3446	168	17	protein	protein	NOUN
gs-3446	168	18	expressed	express	VERB
gs-3446	168	19	in	in	ADP
gs-3446	168	20	neural	neural	ADJ
gs-3446	168	21	progenitor	progenitor	NOUN
gs-3446	168	22	cells	cell	NOUN
gs-3446	168	23	and	and	CCONJ
gs-3446	168	24	nscs	nscs	PROPN
gs-3446	168	25	.	.	PUNCT
gs-3446	169	1	nestin	nestin	PROPN
gs-3446	169	2	is	be	AUX
gs-3446	169	3	often	often	ADV
gs-3446	169	4	used	use	VERB
gs-3446	169	5	as	as	ADP
gs-3446	169	6	a	a	DET
gs-3446	169	7	marker	marker	NOUN
gs-3446	169	8	for	for	ADP
gs-3446	169	9	undifferentiated	undifferentiated	ADJ
gs-3446	169	10	neural	neural	ADJ
gs-3446	169	11	cells	cell	NOUN
gs-3446	169	12	.	.	PUNCT
gs-3446	170	1	○	○	PROPN
gs-3446	170	2	sox1/2	sox1/2	PROPN
gs-3446	170	3	:	:	PUNCT
gs-3446	170	4	transcription	transcription	NOUN
gs-3446	170	5	factors	factor	NOUN
gs-3446	170	6	involved	involve	VERB
gs-3446	170	7	in	in	ADP
gs-3446	170	8	neural	neural	ADJ
gs-3446	170	9	development	development	NOUN
gs-3446	170	10	and	and	CCONJ
gs-3446	170	11	maintenance	maintenance	NOUN
gs-3446	170	12	of	of	ADP
gs-3446	170	13	nscs	nscs	PROPN
gs-3446	170	14	.	.	PUNCT
gs-3446	171	1	○	○	PROPN
gs-3446	171	2	musashi-1	musashi-1	PROPN
gs-3446	171	3	:	:	PUNCT
gs-3446	171	4	an	an	DET
gs-3446	171	5	rna	rna	NOUN
gs-3446	171	6	-	-	PUNCT
gs-3446	171	7	binding	bind	VERB
gs-3446	171	8	protein	protein	NOUN
gs-3446	171	9	expressed	express	VERB
gs-3446	171	10	in	in	ADP
gs-3446	171	11	nscs	nscs	ADJ
gs-3446	171	12	and	and	CCONJ
gs-3446	171	13	progenitor	progenitor	NOUN
gs-3446	171	14	cells	cell	NOUN
gs-3446	171	15	,	,	PUNCT
gs-3446	171	16	playing	play	VERB
gs-3446	171	17	a	a	DET
gs-3446	171	18	role	role	NOUN
gs-3446	171	19	in	in	ADP
gs-3446	171	20	maintaining	maintain	VERB
gs-3446	171	21	the	the	DET
gs-3446	171	22	stem	stem	NOUN
gs-3446	171	23	cell	cell	NOUN
gs-3446	171	24	state	state	NOUN
gs-3446	171	25	.	.	PUNCT
gs-3446	172	1	○	○	PROPN
gs-3446	172	2	gfap	gfap	PROPN
gs-3446	172	3	(	(	PUNCT
gs-3446	172	4	glial	glial	ADJ
gs-3446	172	5	fibrillary	fibrillary	ADJ
gs-3446	172	6	acidic	acidic	ADJ
gs-3446	172	7	protein	protein	NOUN
gs-3446	172	8	):	):	PUNCT
gs-3446	172	9	expressed	express	VERB
gs-3446	172	10	in	in	ADP
gs-3446	172	11	astrocytes	astrocyte	NOUN
gs-3446	172	12	and	and	CCONJ
gs-3446	172	13	some	some	DET
gs-3446	172	14	neural	neural	ADJ
gs-3446	172	15	stem	stem	NOUN
gs-3446	172	16	cells	cell	NOUN
gs-3446	172	17	,	,	PUNCT
gs-3446	172	18	often	often	ADV
gs-3446	172	19	used	use	VERB
gs-3446	172	20	to	to	PART
gs-3446	172	21	identify	identify	VERB
gs-3446	172	22	glial	glial	ADJ
gs-3446	172	23	lineage	lineage	NOUN
gs-3446	172	24	cells	cell	NOUN
gs-3446	172	25	.	.	PUNCT
gs-3446	173	1	5	5	X
gs-3446	173	2	.	.	X
gs-3446	173	3	cancer	cancer	NOUN
gs-3446	173	4	stem	stem	NOUN
gs-3446	173	5	cell	cell	NOUN
gs-3446	173	6	(	(	PUNCT
gs-3446	173	7	csc	csc	PROPN
gs-3446	173	8	)	)	PUNCT
gs-3446	173	9	markers	marker	NOUN
gs-3446	173	10	:	:	PUNCT
gs-3446	173	11	○	○	PROPN
gs-3446	173	12	cd44	cd44	PROPN
gs-3446	173	13	:	:	PUNCT
gs-3446	173	14	expressed	express	VERB
gs-3446	173	15	on	on	ADP
gs-3446	173	16	cancer	cancer	NOUN
gs-3446	173	17	stem	stem	NOUN
gs-3446	173	18	cells	cell	NOUN
gs-3446	173	19	in	in	ADP
gs-3446	173	20	various	various	ADJ
gs-3446	173	21	malignancies	malignancy	NOUN
gs-3446	173	22	,	,	PUNCT
gs-3446	173	23	including	include	VERB
gs-3446	173	24	breast	breast	NOUN
gs-3446	173	25	,	,	PUNCT
gs-3446	173	26	prostate	prostate	NOUN
gs-3446	173	27	,	,	PUNCT
gs-3446	173	28	and	and	CCONJ
gs-3446	173	29	colon	colon	NOUN
gs-3446	173	30	cancers	cancer	NOUN
gs-3446	173	31	.	.	PUNCT
gs-3446	174	1	○	○	PROPN
gs-3446	174	2	cd133	cd133	PROPN
gs-3446	174	3	:	:	PUNCT
gs-3446	174	4	a	a	DET
gs-3446	174	5	marker	marker	NOUN
gs-3446	174	6	for	for	ADP
gs-3446	174	7	cancer	cancer	NOUN
gs-3446	174	8	stem	stem	NOUN
gs-3446	174	9	cells	cell	NOUN
gs-3446	174	10	in	in	ADP
gs-3446	174	11	the	the	DET
gs-3446	174	12	brain	brain	NOUN
gs-3446	174	13	,	,	PUNCT
gs-3446	174	14	colon	colon	NOUN
gs-3446	174	15	,	,	PUNCT
gs-3446	174	16	and	and	CCONJ
gs-3446	174	17	other	other	ADJ
gs-3446	174	18	solid	solid	ADJ
gs-3446	174	19	tumors	tumor	NOUN
gs-3446	174	20	.	.	PUNCT
gs-3446	175	1	○	○	PROPN
gs-3446	175	2	aldh1	aldh1	PROPN
gs-3446	175	3	(	(	PUNCT
gs-3446	175	4	aldehyde	aldehyde	NOUN
gs-3446	175	5	dehydrogenase	dehydrogenase	NOUN
gs-3446	175	6	1	1	NUM
gs-3446	175	7	):	):	PUNCT
gs-3446	175	8	an	an	DET
gs-3446	175	9	enzyme	enzyme	NOUN
gs-3446	175	10	involved	involve	VERB
gs-3446	175	11	in	in	ADP
gs-3446	175	12	detoxification	detoxification	NOUN
gs-3446	175	13	and	and	CCONJ
gs-3446	175	14	stem	stem	NOUN
gs-3446	175	15	cell	cell	NOUN
gs-3446	175	16	maintenance	maintenance	NOUN
gs-3446	175	17	,	,	PUNCT
gs-3446	175	18	often	often	ADV
gs-3446	175	19	used	use	VERB
gs-3446	175	20	to	to	PART
gs-3446	175	21	identify	identify	VERB
gs-3446	175	22	cscs	cscs	PROPN
gs-3446	175	23	in	in	ADP
gs-3446	175	24	breast	breast	NOUN
gs-3446	175	25	and	and	CCONJ
gs-3446	175	26	other	other	ADJ
gs-3446	175	27	cancers	cancer	NOUN
gs-3446	175	28	.	.	PUNCT
gs-3446	176	1	○	○	ADJ
gs-3446	176	2	epcam	epcam	PROPN
gs-3446	176	3	(	(	PUNCT
gs-3446	176	4	epithelial	epithelial	ADJ
gs-3446	176	5	cell	cell	NOUN
gs-3446	176	6	adhesion	adhesion	NOUN
gs-3446	176	7	molecule	molecule	NOUN
gs-3446	176	8	):	):	PUNCT
gs-3446	176	9	expressed	express	VERB
gs-3446	176	10	on	on	ADP
gs-3446	176	11	epithelial	epithelial	ADJ
gs-3446	176	12	-	-	PUNCT
gs-3446	176	13	derived	derive	VERB
gs-3446	176	14	cancer	cancer	NOUN
gs-3446	176	15	stem	stem	NOUN
gs-3446	176	16	cells	cell	NOUN
gs-3446	176	17	,	,	PUNCT
gs-3446	176	18	particularly	particularly	ADV
gs-3446	176	19	in	in	ADP
gs-3446	176	20	colorectal	colorectal	ADJ
gs-3446	176	21	and	and	CCONJ
gs-3446	176	22	pancreatic	pancreatic	ADJ
gs-3446	176	23	cancers	cancer	NOUN
gs-3446	176	24	(	(	PUNCT
gs-3446	176	25	dominici	dominici	PROPN
gs-3446	176	26	et	et	PROPN
gs-3446	176	27	al	al	PROPN
gs-3446	176	28	.	.	PROPN
gs-3446	176	29	2006	2006	NUM
gs-3446	176	30	)	)	PUNCT
gs-3446	176	31	.	.	PUNCT
gs-3446	177	1	applications	application	NOUN
gs-3446	177	2	of	of	ADP
gs-3446	177	3	stem	stem	NOUN
gs-3446	177	4	cell	cell	NOUN
gs-3446	177	5	markers	marker	NOUN
gs-3446	177	6	1	1	NUM
gs-3446	177	7	.	.	PUNCT
gs-3446	177	8	identification	identification	NOUN
gs-3446	177	9	and	and	CCONJ
gs-3446	177	10	isolation	isolation	NOUN
gs-3446	177	11	:	:	PUNCT
gs-3446	177	12	stem	stem	NOUN
gs-3446	177	13	cell	cell	NOUN
gs-3446	177	14	markers	marker	NOUN
gs-3446	177	15	are	be	AUX
gs-3446	177	16	essential	essential	ADJ
gs-3446	177	17	for	for	ADP
gs-3446	177	18	identifying	identify	VERB
gs-3446	177	19	and	and	CCONJ
gs-3446	177	20	isolating	isolate	VERB
gs-3446	177	21	specific	specific	ADJ
gs-3446	177	22	stem	stem	NOUN
gs-3446	177	23	cell	cell	NOUN
gs-3446	177	24	populations	population	NOUN
gs-3446	177	25	from	from	ADP
gs-3446	177	26	tissues	tissue	NOUN
gs-3446	177	27	or	or	CCONJ
gs-3446	177	28	cultures	culture	NOUN
gs-3446	177	29	.	.	PUNCT
gs-3446	178	1	techniques	technique	NOUN
gs-3446	178	2	such	such	ADJ
gs-3446	178	3	as	as	ADP
gs-3446	178	4	flow	flow	NOUN
gs-3446	178	5	cytometry	cytometry	NOUN
gs-3446	178	6	,	,	PUNCT
gs-3446	178	7	magnetic	magnetic	ADJ
gs-3446	178	8	georgian	georgian	ADJ
gs-3446	178	9	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3446	178	10	მეცნიერები	მეცნიერები	NOUN
gs-3446	178	11	ტ.	ტ.	VERB
gs-3446	178	12	7	7	NUM
gs-3446	178	13	n	n	PRON
gs-3446	178	14	1	1	NUM
gs-3446	178	15	,	,	PUNCT
gs-3446	178	16	2025	2025	NUM
gs-3446	178	17	282	282	NUM
gs-3446	178	18	activated	activate	VERB
gs-3446	178	19	cell	cell	NOUN
gs-3446	178	20	sorting	sorting	NOUN
gs-3446	178	21	(	(	PUNCT
gs-3446	178	22	macs	mac	NOUN
gs-3446	178	23	)	)	PUNCT
gs-3446	178	24	,	,	PUNCT
gs-3446	178	25	and	and	CCONJ
gs-3446	178	26	fluorescence	fluorescence	ADJ
gs-3446	178	27	-	-	PUNCT
gs-3446	178	28	activated	activate	VERB
gs-3446	178	29	cell	cell	NOUN
gs-3446	178	30	sorting	sort	VERB
gs-3446	178	31	(	(	PUNCT
gs-3446	178	32	facs	fac	NOUN
gs-3446	178	33	)	)	PUNCT
gs-3446	178	34	rely	rely	VERB
gs-3446	178	35	on	on	ADP
gs-3446	178	36	these	these	DET
gs-3446	178	37	markers	marker	NOUN
gs-3446	178	38	to	to	PART
gs-3446	178	39	purify	purify	VERB
gs-3446	178	40	stem	stem	NOUN
gs-3446	178	41	cells	cell	NOUN
gs-3446	178	42	for	for	ADP
gs-3446	178	43	research	research	NOUN
gs-3446	178	44	or	or	CCONJ
gs-3446	178	45	therapeutic	therapeutic	ADJ
gs-3446	178	46	applications	application	NOUN
gs-3446	178	47	.	.	PUNCT
gs-3446	179	1	2	2	X
gs-3446	179	2	.	.	X
gs-3446	179	3	characterization	characterization	NOUN
gs-3446	179	4	:	:	PUNCT
gs-3446	180	1	markers	marker	NOUN
gs-3446	180	2	help	help	VERB
gs-3446	180	3	characterize	characterize	VERB
gs-3446	180	4	the	the	DET
gs-3446	180	5	potency	potency	NOUN
gs-3446	180	6	and	and	CCONJ
gs-3446	180	7	differentiation	differentiation	NOUN
gs-3446	180	8	state	state	NOUN
gs-3446	180	9	of	of	ADP
gs-3446	180	10	stem	stem	NOUN
gs-3446	180	11	cells	cell	NOUN
gs-3446	180	12	.	.	PUNCT
gs-3446	181	1	for	for	ADP
gs-3446	181	2	example	example	NOUN
gs-3446	181	3	,	,	PUNCT
gs-3446	181	4	the	the	DET
gs-3446	181	5	presence	presence	NOUN
gs-3446	181	6	of	of	ADP
gs-3446	181	7	oct4	oct4	PROPN
gs-3446	181	8	,	,	PUNCT
gs-3446	181	9	sox2	sox2	NOUN
gs-3446	181	10	,	,	PUNCT
gs-3446	181	11	and	and	CCONJ
gs-3446	181	12	nanog	nanog	PROPN
gs-3446	181	13	indicates	indicate	VERB
gs-3446	181	14	pluripotency	pluripotency	NOUN
gs-3446	181	15	,	,	PUNCT
gs-3446	181	16	while	while	SCONJ
gs-3446	181	17	the	the	DET
gs-3446	181	18	expression	expression	NOUN
gs-3446	181	19	of	of	ADP
gs-3446	181	20	lineage	lineage	NOUN
gs-3446	181	21	-	-	PUNCT
gs-3446	181	22	specific	specific	ADJ
gs-3446	181	23	markers	marker	NOUN
gs-3446	181	24	(	(	PUNCT
gs-3446	181	25	e.g.	e.g.	ADV
gs-3446	181	26	,	,	PUNCT
gs-3446	181	27	cd34	cd34	PROPN
gs-3446	181	28	for	for	ADP
gs-3446	181	29	hematopoietic	hematopoietic	ADJ
gs-3446	181	30	cells	cell	NOUN
gs-3446	181	31	or	or	CCONJ
gs-3446	181	32	nestin	nestin	NOUN
gs-3446	181	33	for	for	ADP
gs-3446	181	34	neural	neural	ADJ
gs-3446	181	35	cells	cell	NOUN
gs-3446	181	36	)	)	PUNCT
gs-3446	181	37	suggests	suggest	VERB
gs-3446	181	38	differentiation	differentiation	NOUN
gs-3446	181	39	.	.	PUNCT
gs-3446	182	1	3	3	X
gs-3446	182	2	.	.	X
gs-3446	182	3	disease	disease	NOUN
gs-3446	182	4	modeling	modeling	NOUN
gs-3446	182	5	:	:	PUNCT
gs-3446	182	6	stem	stem	NOUN
gs-3446	182	7	cell	cell	NOUN
gs-3446	182	8	markers	marker	NOUN
gs-3446	182	9	are	be	AUX
gs-3446	182	10	used	use	VERB
gs-3446	182	11	to	to	PART
gs-3446	182	12	generate	generate	VERB
gs-3446	182	13	disease	disease	NOUN
gs-3446	182	14	models	model	NOUN
gs-3446	182	15	using	use	VERB
gs-3446	182	16	ipscs	ipsc	NOUN
gs-3446	182	17	.	.	PUNCT
gs-3446	183	1	by	by	ADP
gs-3446	183	2	reprogramming	reprogramme	VERB
gs-3446	183	3	somatic	somatic	ADJ
gs-3446	183	4	cells	cell	NOUN
gs-3446	183	5	from	from	ADP
gs-3446	183	6	patients	patient	NOUN
gs-3446	183	7	with	with	ADP
gs-3446	183	8	genetic	genetic	ADJ
gs-3446	183	9	disorders	disorder	NOUN
gs-3446	183	10	,	,	PUNCT
gs-3446	183	11	researchers	researcher	NOUN
gs-3446	183	12	can	can	AUX
gs-3446	183	13	study	study	VERB
gs-3446	183	14	disease	disease	NOUN
gs-3446	183	15	mechanisms	mechanism	NOUN
gs-3446	183	16	and	and	CCONJ
gs-3446	183	17	screen	screen	NOUN
gs-3446	183	18	potential	potential	ADJ
gs-3446	183	19	therapies	therapy	NOUN
gs-3446	183	20	.	.	PUNCT
gs-3446	184	1	4	4	X
gs-3446	184	2	.	.	NOUN
gs-3446	184	3	regenerative	regenerative	ADJ
gs-3446	184	4	medicine	medicine	NOUN
gs-3446	184	5	:	:	PUNCT
gs-3446	184	6	in	in	ADP
gs-3446	184	7	regenerative	regenerative	ADJ
gs-3446	184	8	medicine	medicine	NOUN
gs-3446	184	9	,	,	PUNCT
gs-3446	184	10	stem	stem	NOUN
gs-3446	184	11	cell	cell	NOUN
gs-3446	184	12	markers	marker	NOUN
gs-3446	184	13	are	be	AUX
gs-3446	184	14	used	use	VERB
gs-3446	184	15	to	to	PART
gs-3446	184	16	monitor	monitor	VERB
gs-3446	184	17	the	the	DET
gs-3446	184	18	differentiation	differentiation	NOUN
gs-3446	184	19	of	of	ADP
gs-3446	184	20	stem	stem	NOUN
gs-3446	184	21	cells	cell	NOUN
gs-3446	184	22	into	into	ADP
gs-3446	184	23	specific	specific	ADJ
gs-3446	184	24	cell	cell	NOUN
gs-3446	184	25	types	type	NOUN
gs-3446	184	26	for	for	ADP
gs-3446	184	27	transplantation	transplantation	NOUN
gs-3446	184	28	.	.	PUNCT
gs-3446	185	1	for	for	ADP
gs-3446	185	2	example	example	NOUN
gs-3446	185	3	,	,	PUNCT
gs-3446	185	4	the	the	DET
gs-3446	185	5	expression	expression	NOUN
gs-3446	185	6	of	of	ADP
gs-3446	185	7	cardiac	cardiac	ADJ
gs-3446	185	8	markers	marker	NOUN
gs-3446	185	9	(	(	PUNCT
gs-3446	185	10	e.g.	e.g.	ADV
gs-3446	185	11	,	,	PUNCT
gs-3446	185	12	troponin	troponin	PROPN
gs-3446	185	13	t	t	PROPN
gs-3446	185	14	)	)	PUNCT
gs-3446	185	15	in	in	ADP
gs-3446	185	16	ipsc	ipsc	NOUN
gs-3446	185	17	-	-	PUNCT
gs-3446	185	18	derived	derive	VERB
gs-3446	185	19	cardiomyocytes	cardiomyocyte	NOUN
gs-3446	185	20	ensures	ensure	VERB
gs-3446	185	21	their	their	PRON
gs-3446	185	22	suitability	suitability	NOUN
gs-3446	185	23	for	for	ADP
gs-3446	185	24	heart	heart	NOUN
gs-3446	185	25	repair	repair	NOUN
gs-3446	185	26	.	.	PUNCT
gs-3446	186	1	5	5	X
gs-3446	186	2	.	.	X
gs-3446	186	3	cancer	cancer	NOUN
gs-3446	186	4	research	research	NOUN
gs-3446	186	5	:	:	PUNCT
gs-3446	186	6	cancer	cancer	NOUN
gs-3446	186	7	stem	stem	NOUN
gs-3446	186	8	cell	cell	NOUN
gs-3446	186	9	markers	marker	NOUN
gs-3446	186	10	are	be	AUX
gs-3446	186	11	critical	critical	ADJ
gs-3446	186	12	for	for	ADP
gs-3446	186	13	understanding	understand	VERB
gs-3446	186	14	tumor	tumor	NOUN
gs-3446	186	15	biology	biology	NOUN
gs-3446	186	16	and	and	CCONJ
gs-3446	186	17	developing	develop	VERB
gs-3446	186	18	targeted	target	VERB
gs-3446	186	19	therapies	therapy	NOUN
gs-3446	186	20	.	.	PUNCT
gs-3446	187	1	by	by	ADP
gs-3446	187	2	identifying	identify	VERB
gs-3446	187	3	and	and	CCONJ
gs-3446	187	4	isolating	isolate	VERB
gs-3446	187	5	cscs	csc	NOUN
gs-3446	187	6	,	,	PUNCT
gs-3446	187	7	researchers	researcher	NOUN
gs-3446	187	8	can	can	AUX
gs-3446	187	9	study	study	VERB
gs-3446	187	10	their	their	PRON
gs-3446	187	11	role	role	NOUN
gs-3446	187	12	in	in	ADP
gs-3446	187	13	tumor	tumor	NOUN
gs-3446	187	14	initiation	initiation	NOUN
gs-3446	187	15	,	,	PUNCT
gs-3446	187	16	progression	progression	NOUN
gs-3446	187	17	,	,	PUNCT
gs-3446	187	18	and	and	CCONJ
gs-3446	187	19	resistance	resistance	NOUN
gs-3446	187	20	to	to	ADP
gs-3446	187	21	treatment	treatment	NOUN
gs-3446	187	22	(	(	PUNCT
gs-3446	187	23	aphkhazava	aphkhazava	NOUN
gs-3446	187	24	et	et	PROPN
gs-3446	187	25	al	al	PROPN
gs-3446	187	26	.	.	PROPN
gs-3446	187	27	2024	2024	NUM
gs-3446	187	28	)	)	PUNCT
gs-3446	187	29	.	.	PUNCT
gs-3446	188	1	challenges	challenge	NOUN
gs-3446	188	2	and	and	CCONJ
gs-3446	188	3	future	future	ADJ
gs-3446	188	4	directions	direction	NOUN
gs-3446	188	5	despite	despite	SCONJ
gs-3446	188	6	their	their	PRON
gs-3446	188	7	utility	utility	NOUN
gs-3446	188	8	,	,	PUNCT
gs-3446	188	9	stem	stem	NOUN
gs-3446	188	10	cell	cell	NOUN
gs-3446	188	11	markers	marker	NOUN
gs-3446	188	12	have	have	VERB
gs-3446	188	13	limitations	limitation	NOUN
gs-3446	188	14	.	.	PUNCT
gs-3446	189	1	some	some	DET
gs-3446	189	2	markers	marker	NOUN
gs-3446	189	3	are	be	AUX
gs-3446	189	4	not	not	PART
gs-3446	189	5	exclusive	exclusive	ADJ
gs-3446	189	6	to	to	PART
gs-3446	189	7	stem	stem	VERB
gs-3446	189	8	cells	cell	NOUN
gs-3446	189	9	and	and	CCONJ
gs-3446	189	10	may	may	AUX
gs-3446	189	11	be	be	AUX
gs-3446	189	12	expressed	express	VERB
gs-3446	189	13	in	in	ADP
gs-3446	189	14	other	other	ADJ
gs-3446	189	15	cell	cell	NOUN
gs-3446	189	16	types	type	NOUN
gs-3446	189	17	,	,	PUNCT
gs-3446	189	18	leading	lead	VERB
gs-3446	189	19	to	to	ADP
gs-3446	189	20	potential	potential	ADJ
gs-3446	189	21	contamination	contamination	NOUN
gs-3446	189	22	.	.	PUNCT
gs-3446	190	1	additionally	additionally	ADV
gs-3446	190	2	,	,	PUNCT
gs-3446	190	3	marker	marker	NOUN
gs-3446	190	4	expression	expression	NOUN
gs-3446	190	5	can	can	AUX
gs-3446	190	6	vary	vary	VERB
gs-3446	190	7	depending	depend	VERB
gs-3446	190	8	on	on	ADP
gs-3446	190	9	the	the	DET
gs-3446	190	10	cell	cell	NOUN
gs-3446	190	11	's	's	PART
gs-3446	190	12	microenvironment	microenvironment	NOUN
gs-3446	190	13	,	,	PUNCT
gs-3446	190	14	differentiation	differentiation	NOUN
gs-3446	190	15	state	state	NOUN
gs-3446	190	16	,	,	PUNCT
gs-3446	190	17	or	or	CCONJ
gs-3446	190	18	species	specie	NOUN
gs-3446	190	19	.	.	PUNCT
gs-3446	191	1	future	future	ADJ
gs-3446	191	2	research	research	NOUN
gs-3446	191	3	aims	aim	VERB
gs-3446	191	4	to	to	PART
gs-3446	191	5	identify	identify	VERB
gs-3446	191	6	more	more	ADV
gs-3446	191	7	specific	specific	ADJ
gs-3446	191	8	and	and	CCONJ
gs-3446	191	9	universal	universal	ADJ
gs-3446	191	10	markers	marker	NOUN
gs-3446	191	11	,	,	PUNCT
gs-3446	191	12	as	as	ADV
gs-3446	191	13	well	well	ADV
gs-3446	191	14	as	as	ADP
gs-3446	191	15	develop	develop	VERB
gs-3446	191	16	advanced	advanced	ADJ
gs-3446	191	17	techniques	technique	NOUN
gs-3446	191	18	for	for	ADP
gs-3446	191	19	single	single	ADJ
gs-3446	191	20	-	-	PUNCT
gs-3446	191	21	cell	cell	NOUN
gs-3446	191	22	analysis	analysis	NOUN
gs-3446	191	23	to	to	PART
gs-3446	191	24	better	well	ADV
gs-3446	191	25	understand	understand	VERB
gs-3446	191	26	stem	stem	NOUN
gs-3446	191	27	cell	cell	NOUN
gs-3446	191	28	heterogeneity	heterogeneity	NOUN
gs-3446	191	29	[	[	X
gs-3446	191	30	80	80	NUM
gs-3446	191	31	]	]	PUNCT
gs-3446	191	32	.	.	PUNCT
gs-3446	192	1	in	in	ADP
gs-3446	192	2	conclusion	conclusion	NOUN
gs-3446	192	3	,	,	PUNCT
gs-3446	192	4	stem	stem	NOUN
gs-3446	192	5	cell	cell	NOUN
gs-3446	192	6	markers	marker	NOUN
gs-3446	192	7	are	be	AUX
gs-3446	192	8	indispensable	indispensable	ADJ
gs-3446	192	9	tools	tool	NOUN
gs-3446	192	10	in	in	ADP
gs-3446	192	11	stem	stem	NOUN
gs-3446	192	12	cell	cell	NOUN
gs-3446	192	13	biology	biology	NOUN
gs-3446	192	14	,	,	PUNCT
gs-3446	192	15	enabling	enable	VERB
gs-3446	192	16	the	the	DET
gs-3446	192	17	identification	identification	NOUN
gs-3446	192	18	,	,	PUNCT
gs-3446	192	19	isolation	isolation	NOUN
gs-3446	192	20	,	,	PUNCT
gs-3446	192	21	and	and	CCONJ
gs-3446	192	22	characterization	characterization	NOUN
gs-3446	192	23	of	of	ADP
gs-3446	192	24	stem	stem	NOUN
gs-3446	192	25	cells	cell	NOUN
gs-3446	192	26	across	across	ADP
gs-3446	192	27	various	various	ADJ
gs-3446	192	28	applications	application	NOUN
gs-3446	192	29	.	.	PUNCT
gs-3446	193	1	continued	continue	VERB
gs-3446	193	2	advancements	advancement	NOUN
gs-3446	193	3	in	in	ADP
gs-3446	193	4	marker	marker	NOUN
gs-3446	193	5	discovery	discovery	NOUN
gs-3446	193	6	and	and	CCONJ
gs-3446	193	7	analysis	analysis	NOUN
gs-3446	193	8	will	will	AUX
gs-3446	193	9	enhance	enhance	VERB
gs-3446	193	10	our	our	PRON
gs-3446	193	11	ability	ability	NOUN
gs-3446	193	12	to	to	ADP
gs-3446	193	13	harness	harness	ADJ
gs-3446	193	14	stem	stem	NOUN
gs-3446	193	15	cells	cell	NOUN
gs-3446	193	16	for	for	ADP
gs-3446	193	17	regenerative	regenerative	ADJ
gs-3446	193	18	medicine	medicine	NOUN
gs-3446	193	19	,	,	PUNCT
gs-3446	193	20	disease	disease	NOUN
gs-3446	193	21	modeling	modeling	NOUN
gs-3446	193	22	,	,	PUNCT
gs-3446	193	23	and	and	CCONJ
gs-3446	193	24	cancer	cancer	NOUN
gs-3446	193	25	therapy	therapy	NOUN
gs-3446	193	26	.	.	PUNCT
gs-3446	194	1	stem	stem	NOUN
gs-3446	194	2	cells	cell	NOUN
gs-3446	194	3	and	and	CCONJ
gs-3446	194	4	germ	germ	NOUN
gs-3446	194	5	cells	cell	NOUN
gs-3446	194	6	stem	stem	VERB
gs-3446	194	7	cells	cell	NOUN
gs-3446	194	8	and	and	CCONJ
gs-3446	194	9	germ	germ	NOUN
gs-3446	194	10	cells	cell	NOUN
gs-3446	194	11	are	be	AUX
gs-3446	194	12	fundamental	fundamental	ADJ
gs-3446	194	13	to	to	ADP
gs-3446	194	14	the	the	DET
gs-3446	194	15	development	development	NOUN
gs-3446	194	16	,	,	PUNCT
gs-3446	194	17	regeneration	regeneration	NOUN
gs-3446	194	18	,	,	PUNCT
gs-3446	194	19	and	and	CCONJ
gs-3446	194	20	reproduction	reproduction	NOUN
gs-3446	194	21	of	of	ADP
gs-3446	194	22	multicellular	multicellular	ADJ
gs-3446	194	23	organisms	organism	NOUN
gs-3446	194	24	.	.	PUNCT
gs-3446	195	1	stem	stem	NOUN
gs-3446	195	2	cells	cell	NOUN
gs-3446	195	3	,	,	PUNCT
gs-3446	195	4	characterized	characterize	VERB
gs-3446	195	5	by	by	ADP
gs-3446	195	6	their	their	PRON
gs-3446	195	7	ability	ability	NOUN
gs-3446	195	8	to	to	PART
gs-3446	195	9	self	self	NOUN
gs-3446	195	10	-	-	PUNCT
gs-3446	195	11	renew	renew	VERB
gs-3446	195	12	and	and	CCONJ
gs-3446	195	13	differentiate	differentiate	VERB
gs-3446	195	14	into	into	ADP
gs-3446	195	15	specialized	specialized	ADJ
gs-3446	195	16	cell	cell	NOUN
gs-3446	195	17	types	type	NOUN
gs-3446	195	18	,	,	PUNCT
gs-3446	195	19	play	play	VERB
gs-3446	195	20	a	a	DET
gs-3446	195	21	crucial	crucial	ADJ
gs-3446	195	22	role	role	NOUN
gs-3446	195	23	in	in	ADP
gs-3446	195	24	tissue	tissue	NOUN
gs-3446	195	25	maintenance	maintenance	NOUN
gs-3446	195	26	and	and	CCONJ
gs-3446	195	27	repair	repair	NOUN
gs-3446	195	28	.	.	PUNCT
gs-3446	196	1	germ	germ	NOUN
gs-3446	196	2	cells	cell	NOUN
gs-3446	196	3	,	,	PUNCT
gs-3446	196	4	on	on	ADP
gs-3446	196	5	the	the	DET
gs-3446	196	6	other	other	ADJ
gs-3446	196	7	hand	hand	NOUN
gs-3446	196	8	,	,	PUNCT
gs-3446	196	9	are	be	AUX
gs-3446	196	10	unique	unique	ADJ
gs-3446	196	11	cells	cell	NOUN
gs-3446	196	12	responsible	responsible	ADJ
gs-3446	196	13	for	for	ADP
gs-3446	196	14	transmitting	transmit	VERB
gs-3446	196	15	genetic	genetic	ADJ
gs-3446	196	16	information	information	NOUN
gs-3446	196	17	to	to	ADP
gs-3446	196	18	the	the	DET
gs-3446	196	19	next	next	ADJ
gs-3446	196	20	generation	generation	NOUN
gs-3446	196	21	through	through	ADP
gs-3446	196	22	gametogenesis	gametogenesis	NOUN
gs-3446	196	23	.	.	PUNCT
gs-3446	197	1	the	the	DET
gs-3446	197	2	interplay	interplay	NOUN
gs-3446	197	3	between	between	ADP
gs-3446	197	4	these	these	DET
gs-3446	197	5	two	two	NUM
gs-3446	197	6	cell	cell	NOUN
gs-3446	197	7	types	type	NOUN
gs-3446	197	8	has	have	VERB
gs-3446	197	9	significant	significant	ADJ
gs-3446	197	10	implications	implication	NOUN
gs-3446	197	11	for	for	ADP
gs-3446	197	12	developmental	developmental	ADJ
gs-3446	197	13	biology	biology	NOUN
gs-3446	197	14	,	,	PUNCT
gs-3446	197	15	regenerative	regenerative	ADJ
gs-3446	197	16	medicine	medicine	NOUN
gs-3446	197	17	,	,	PUNCT
gs-3446	197	18	and	and	CCONJ
gs-3446	197	19	reproductive	reproductive	ADJ
gs-3446	197	20	health	health	NOUN
gs-3446	197	21	.	.	PUNCT
gs-3446	198	1	the	the	DET
gs-3446	198	2	study	study	NOUN
gs-3446	198	3	of	of	ADP
gs-3446	198	4	stem	stem	NOUN
gs-3446	198	5	cells	cell	NOUN
gs-3446	198	6	and	and	CCONJ
gs-3446	198	7	germ	germ	NOUN
gs-3446	198	8	cells	cell	NOUN
gs-3446	198	9	has	have	AUX
gs-3446	198	10	revolutionized	revolutionize	VERB
gs-3446	198	11	the	the	DET
gs-3446	198	12	fields	field	NOUN
gs-3446	198	13	of	of	ADP
gs-3446	198	14	biology	biology	NOUN
gs-3446	198	15	and	and	CCONJ
gs-3446	198	16	medicine	medicine	NOUN
gs-3446	198	17	.	.	PUNCT
gs-3446	199	1	advances	advance	NOUN
gs-3446	199	2	in	in	ADP
gs-3446	199	3	stem	stem	NOUN
gs-3446	199	4	cell	cell	NOUN
gs-3446	199	5	research	research	NOUN
gs-3446	199	6	have	have	AUX
gs-3446	199	7	led	lead	VERB
gs-3446	199	8	to	to	ADP
gs-3446	199	9	groundbreaking	groundbreake	VERB
gs-3446	199	10	therapies	therapy	NOUN
gs-3446	199	11	for	for	ADP
gs-3446	199	12	degenerative	degenerative	ADJ
gs-3446	199	13	diseases	disease	NOUN
gs-3446	199	14	,	,	PUNCT
gs-3446	199	15	while	while	SCONJ
gs-3446	199	16	insights	insight	NOUN
gs-3446	199	17	georgian	georgian	PROPN
gs-3446	199	18	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3446	199	19	მეცნიერები	მეცნიერები	NOUN
gs-3446	199	20	ტ.	ტ.	VERB
gs-3446	199	21	7	7	NUM
gs-3446	199	22	n	n	DET
gs-3446	199	23	1	1	NUM
gs-3446	199	24	,	,	PUNCT
gs-3446	199	25	2025	2025	NUM
gs-3446	199	26	283	283	NUM
gs-3446	199	27	into	into	ADP
gs-3446	199	28	germ	germ	NOUN
gs-3446	199	29	cell	cell	NOUN
gs-3446	199	30	development	development	NOUN
gs-3446	199	31	have	have	AUX
gs-3446	199	32	enhanced	enhance	VERB
gs-3446	199	33	our	our	PRON
gs-3446	199	34	understanding	understanding	NOUN
gs-3446	199	35	of	of	ADP
gs-3446	199	36	fertility	fertility	NOUN
gs-3446	199	37	and	and	CCONJ
gs-3446	199	38	reproductive	reproductive	ADJ
gs-3446	199	39	disorders	disorder	NOUN
gs-3446	199	40	.	.	PUNCT
gs-3446	200	1	understanding	understand	VERB
gs-3446	200	2	the	the	DET
gs-3446	200	3	similarities	similarity	NOUN
gs-3446	200	4	and	and	CCONJ
gs-3446	200	5	distinctions	distinction	NOUN
gs-3446	200	6	between	between	ADP
gs-3446	200	7	these	these	DET
gs-3446	200	8	cell	cell	NOUN
gs-3446	200	9	types	type	NOUN
gs-3446	200	10	provides	provide	VERB
gs-3446	200	11	a	a	DET
gs-3446	200	12	foundation	foundation	NOUN
gs-3446	200	13	for	for	ADP
gs-3446	200	14	exploring	explore	VERB
gs-3446	200	15	their	their	PRON
gs-3446	200	16	potential	potential	ADJ
gs-3446	200	17	applications	application	NOUN
gs-3446	200	18	in	in	ADP
gs-3446	200	19	medical	medical	ADJ
gs-3446	200	20	science	science	NOUN
gs-3446	200	21	.	.	PUNCT
gs-3446	201	1	this	this	DET
gs-3446	201	2	introduction	introduction	NOUN
gs-3446	201	3	will	will	AUX
gs-3446	201	4	provide	provide	VERB
gs-3446	201	5	an	an	DET
gs-3446	201	6	overview	overview	NOUN
gs-3446	201	7	of	of	ADP
gs-3446	201	8	stem	stem	NOUN
gs-3446	201	9	cells	cell	NOUN
gs-3446	201	10	and	and	CCONJ
gs-3446	201	11	germ	germ	NOUN
gs-3446	201	12	cells	cell	NOUN
gs-3446	201	13	,	,	PUNCT
gs-3446	201	14	including	include	VERB
gs-3446	201	15	their	their	PRON
gs-3446	201	16	origins	origin	NOUN
gs-3446	201	17	,	,	PUNCT
gs-3446	201	18	classifications	classification	NOUN
gs-3446	201	19	,	,	PUNCT
gs-3446	201	20	functions	function	NOUN
gs-3446	201	21	,	,	PUNCT
gs-3446	201	22	and	and	CCONJ
gs-3446	201	23	their	their	PRON
gs-3446	201	24	significance	significance	NOUN
gs-3446	201	25	in	in	ADP
gs-3446	201	26	medical	medical	ADJ
gs-3446	201	27	research	research	NOUN
gs-3446	201	28	.	.	PUNCT
gs-3446	202	1	it	it	PRON
gs-3446	202	2	will	will	AUX
gs-3446	202	3	also	also	ADV
gs-3446	202	4	discuss	discuss	VERB
gs-3446	202	5	key	key	ADJ
gs-3446	202	6	ethical	ethical	ADJ
gs-3446	202	7	and	and	CCONJ
gs-3446	202	8	scientific	scientific	ADJ
gs-3446	202	9	challenges	challenge	NOUN
gs-3446	202	10	associated	associate	VERB
gs-3446	202	11	with	with	ADP
gs-3446	202	12	their	their	PRON
gs-3446	202	13	study	study	NOUN
gs-3446	202	14	and	and	CCONJ
gs-3446	202	15	application	application	NOUN
gs-3446	202	16	.	.	PUNCT
gs-3446	203	1	by	by	ADP
gs-3446	203	2	delving	delve	VERB
gs-3446	203	3	into	into	ADP
gs-3446	203	4	the	the	DET
gs-3446	203	5	mechanisms	mechanism	NOUN
gs-3446	203	6	that	that	PRON
gs-3446	203	7	govern	govern	VERB
gs-3446	203	8	their	their	PRON
gs-3446	203	9	development	development	NOUN
gs-3446	203	10	and	and	CCONJ
gs-3446	203	11	differentiation	differentiation	NOUN
gs-3446	203	12	,	,	PUNCT
gs-3446	203	13	this	this	DET
gs-3446	203	14	discussion	discussion	NOUN
gs-3446	203	15	aims	aim	VERB
gs-3446	203	16	to	to	PART
gs-3446	203	17	highlight	highlight	VERB
gs-3446	203	18	the	the	DET
gs-3446	203	19	crucial	crucial	ADJ
gs-3446	203	20	roles	role	NOUN
gs-3446	203	21	of	of	ADP
gs-3446	203	22	these	these	DET
gs-3446	203	23	cells	cell	NOUN
gs-3446	203	24	in	in	ADP
gs-3446	203	25	life	life	NOUN
gs-3446	203	26	sciences	science	NOUN
gs-3446	203	27	and	and	CCONJ
gs-3446	203	28	their	their	PRON
gs-3446	203	29	potential	potential	NOUN
gs-3446	203	30	to	to	PART
gs-3446	203	31	address	address	VERB
gs-3446	203	32	some	some	PRON
gs-3446	203	33	of	of	ADP
gs-3446	203	34	the	the	DET
gs-3446	203	35	most	most	ADV
gs-3446	203	36	pressing	press	VERB
gs-3446	203	37	health	health	NOUN
gs-3446	203	38	issues	issue	NOUN
gs-3446	203	39	of	of	ADP
gs-3446	203	40	the	the	DET
gs-3446	203	41	modern	modern	ADJ
gs-3446	203	42	era	era	NOUN
gs-3446	203	43	.	.	PUNCT
gs-3446	204	1	stem	stem	NOUN
gs-3446	204	2	cells	cell	NOUN
gs-3446	204	3	:	:	PUNCT
gs-3446	204	4	definition	definition	NOUN
gs-3446	204	5	and	and	CCONJ
gs-3446	204	6	classification	classification	NOUN
gs-3446	204	7	stem	stem	NOUN
gs-3446	204	8	cells	cell	NOUN
gs-3446	204	9	are	be	AUX
gs-3446	204	10	undifferentiated	undifferentiated	ADJ
gs-3446	204	11	cells	cell	NOUN
gs-3446	204	12	that	that	PRON
gs-3446	204	13	have	have	VERB
gs-3446	204	14	the	the	DET
gs-3446	204	15	remarkable	remarkable	ADJ
gs-3446	204	16	ability	ability	NOUN
gs-3446	204	17	to	to	AUX
gs-3446	204	18	both	both	CCONJ
gs-3446	204	19	self	self	NOUN
gs-3446	204	20	-	-	PUNCT
gs-3446	204	21	renew	renew	NOUN
gs-3446	204	22	and	and	CCONJ
gs-3446	204	23	differentiate	differentiate	VERB
gs-3446	204	24	into	into	ADP
gs-3446	204	25	various	various	ADJ
gs-3446	204	26	cell	cell	NOUN
gs-3446	204	27	types	type	NOUN
gs-3446	204	28	.	.	PUNCT
gs-3446	205	1	these	these	DET
gs-3446	205	2	properties	property	NOUN
gs-3446	205	3	make	make	VERB
gs-3446	205	4	them	they	PRON
gs-3446	205	5	invaluable	invaluable	ADJ
gs-3446	205	6	for	for	ADP
gs-3446	205	7	the	the	DET
gs-3446	205	8	maintenance	maintenance	NOUN
gs-3446	205	9	and	and	CCONJ
gs-3446	205	10	repair	repair	NOUN
gs-3446	205	11	of	of	ADP
gs-3446	205	12	tissues	tissue	NOUN
gs-3446	205	13	.	.	PUNCT
gs-3446	206	1	stem	stem	NOUN
gs-3446	206	2	cells	cell	NOUN
gs-3446	206	3	can	can	AUX
gs-3446	206	4	be	be	AUX
gs-3446	206	5	classified	classify	VERB
gs-3446	206	6	into	into	ADP
gs-3446	206	7	several	several	ADJ
gs-3446	206	8	categories	category	NOUN
gs-3446	206	9	based	base	VERB
gs-3446	206	10	on	on	ADP
gs-3446	206	11	their	their	PRON
gs-3446	206	12	origin	origin	NOUN
gs-3446	206	13	and	and	CCONJ
gs-3446	206	14	differentiation	differentiation	NOUN
gs-3446	206	15	potential	potential	NOUN
gs-3446	206	16	.	.	PUNCT
gs-3446	207	1	types	type	NOUN
gs-3446	207	2	of	of	ADP
gs-3446	207	3	stem	stem	NOUN
gs-3446	207	4	cells	cell	NOUN
gs-3446	207	5	based	base	VERB
gs-3446	207	6	on	on	ADP
gs-3446	207	7	potency	potency	NOUN
gs-3446	207	8	(	(	PUNCT
gs-3446	207	9	figure	figure	NOUN
gs-3446	207	10	1	1	NUM
gs-3446	207	11	)	)	PUNCT
gs-3446	207	12	○	○	ADJ
gs-3446	207	13	totipotent	totipotent	ADJ
gs-3446	207	14	stem	stem	NOUN
gs-3446	207	15	cells	cell	NOUN
gs-3446	207	16	:	:	PUNCT
gs-3446	207	17	these	these	DET
gs-3446	207	18	cells	cell	NOUN
gs-3446	207	19	have	have	VERB
gs-3446	207	20	the	the	DET
gs-3446	207	21	capacity	capacity	NOUN
gs-3446	207	22	to	to	PART
gs-3446	207	23	develop	develop	VERB
gs-3446	207	24	into	into	ADP
gs-3446	207	25	an	an	DET
gs-3446	207	26	entire	entire	ADJ
gs-3446	207	27	organism	organism	NOUN
gs-3446	207	28	,	,	PUNCT
gs-3446	207	29	including	include	VERB
gs-3446	207	30	both	both	CCONJ
gs-3446	207	31	embryonic	embryonic	ADJ
gs-3446	207	32	and	and	CCONJ
gs-3446	207	33	extraembryonic	extraembryonic	ADJ
gs-3446	207	34	tissues	tissue	NOUN
gs-3446	207	35	.	.	PUNCT
gs-3446	208	1	the	the	DET
gs-3446	208	2	zygote	zygote	NOUN
gs-3446	208	3	and	and	CCONJ
gs-3446	208	4	the	the	DET
gs-3446	208	5	first	first	ADJ
gs-3446	208	6	few	few	ADJ
gs-3446	208	7	divisions	division	NOUN
gs-3446	208	8	of	of	ADP
gs-3446	208	9	embryonic	embryonic	ADJ
gs-3446	208	10	cells	cell	NOUN
gs-3446	208	11	exhibit	exhibit	VERB
gs-3446	208	12	totipotency	totipotency	NOUN
gs-3446	208	13	.	.	PUNCT
gs-3446	209	1	○	○	ADJ
gs-3446	209	2	pluripotent	pluripotent	ADJ
gs-3446	209	3	stem	stem	NOUN
gs-3446	209	4	cells	cell	NOUN
gs-3446	209	5	:	:	PUNCT
gs-3446	209	6	found	find	VERB
gs-3446	209	7	in	in	ADP
gs-3446	209	8	the	the	DET
gs-3446	209	9	inner	inner	ADJ
gs-3446	209	10	cell	cell	NOUN
gs-3446	209	11	mass	mass	NOUN
gs-3446	209	12	of	of	ADP
gs-3446	209	13	the	the	DET
gs-3446	209	14	blastocyst	blastocyst	NOUN
gs-3446	209	15	,	,	PUNCT
gs-3446	209	16	these	these	DET
gs-3446	209	17	cells	cell	NOUN
gs-3446	209	18	can	can	AUX
gs-3446	209	19	give	give	VERB
gs-3446	209	20	rise	rise	NOUN
gs-3446	209	21	to	to	ADP
gs-3446	209	22	all	all	DET
gs-3446	209	23	cell	cell	NOUN
gs-3446	209	24	types	type	NOUN
gs-3446	209	25	of	of	ADP
gs-3446	209	26	the	the	DET
gs-3446	209	27	body	body	NOUN
gs-3446	209	28	but	but	CCONJ
gs-3446	209	29	not	not	PART
gs-3446	209	30	extraembryonic	extraembryonic	ADJ
gs-3446	209	31	tissues	tissue	NOUN
gs-3446	209	32	.	.	PUNCT
gs-3446	210	1	○	○	ADJ
gs-3446	210	2	multipotent	multipotent	NOUN
gs-3446	210	3	stem	stem	NOUN
gs-3446	210	4	cells	cell	NOUN
gs-3446	210	5	:	:	PUNCT
gs-3446	210	6	these	these	DET
gs-3446	210	7	cells	cell	NOUN
gs-3446	210	8	can	can	AUX
gs-3446	210	9	differentiate	differentiate	VERB
gs-3446	210	10	into	into	ADP
gs-3446	210	11	a	a	DET
gs-3446	210	12	specific	specific	ADJ
gs-3446	210	13	range	range	NOUN
gs-3446	210	14	of	of	ADP
gs-3446	210	15	cell	cell	NOUN
gs-3446	210	16	types	type	NOUN
gs-3446	210	17	within	within	ADP
gs-3446	210	18	a	a	DET
gs-3446	210	19	particular	particular	ADJ
gs-3446	210	20	tissue	tissue	NOUN
gs-3446	210	21	or	or	CCONJ
gs-3446	210	22	organ	organ	NOUN
gs-3446	210	23	.	.	PUNCT
gs-3446	211	1	examples	example	NOUN
gs-3446	211	2	include	include	VERB
gs-3446	211	3	hematopoietic	hematopoietic	ADJ
gs-3446	211	4	stem	stem	NOUN
gs-3446	211	5	cells	cell	NOUN
gs-3446	211	6	,	,	PUNCT
gs-3446	211	7	which	which	PRON
gs-3446	211	8	give	give	VERB
gs-3446	211	9	rise	rise	NOUN
gs-3446	211	10	to	to	ADP
gs-3446	211	11	blood	blood	NOUN
gs-3446	211	12	cells	cell	NOUN
gs-3446	211	13	,	,	PUNCT
gs-3446	211	14	and	and	CCONJ
gs-3446	211	15	mesenchymal	mesenchymal	ADJ
gs-3446	211	16	stem	stem	NOUN
gs-3446	211	17	cells	cell	NOUN
gs-3446	211	18	,	,	PUNCT
gs-3446	211	19	which	which	PRON
gs-3446	211	20	contribute	contribute	VERB
gs-3446	211	21	to	to	ADP
gs-3446	211	22	bone	bone	NOUN
gs-3446	211	23	,	,	PUNCT
gs-3446	211	24	cartilage	cartilage	NOUN
gs-3446	211	25	,	,	PUNCT
gs-3446	211	26	and	and	CCONJ
gs-3446	211	27	muscle	muscle	NOUN
gs-3446	211	28	formation	formation	NOUN
gs-3446	211	29	.	.	PUNCT
gs-3446	212	1	○	○	ADJ
gs-3446	212	2	unipotent	unipotent	ADJ
gs-3446	212	3	stem	stem	NOUN
gs-3446	212	4	cells	cell	NOUN
gs-3446	212	5	:	:	PUNCT
gs-3446	212	6	these	these	DET
gs-3446	212	7	cells	cell	NOUN
gs-3446	212	8	have	have	VERB
gs-3446	212	9	the	the	DET
gs-3446	212	10	least	least	ADJ
gs-3446	212	11	differentiation	differentiation	NOUN
gs-3446	212	12	potential	potential	NOUN
gs-3446	212	13	and	and	CCONJ
gs-3446	212	14	can	can	AUX
gs-3446	212	15	only	only	ADV
gs-3446	212	16	generate	generate	VERB
gs-3446	212	17	one	one	NUM
gs-3446	212	18	specific	specific	ADJ
gs-3446	212	19	cell	cell	NOUN
gs-3446	212	20	type	type	NOUN
gs-3446	212	21	while	while	SCONJ
gs-3446	212	22	maintaining	maintain	VERB
gs-3446	212	23	self	self	NOUN
gs-3446	212	24	-	-	PUNCT
gs-3446	212	25	renewal	renewal	NOUN
gs-3446	212	26	properties	property	NOUN
gs-3446	212	27	(	(	PUNCT
gs-3446	212	28	aphkhazava	aphkhazava	NOUN
gs-3446	212	29	et	et	PROPN
gs-3446	212	30	al	al	PROPN
gs-3446	212	31	.	.	PROPN
gs-3446	212	32	2023	2023	NUM
gs-3446	212	33	)	)	PUNCT
gs-3446	212	34	.	.	PUNCT
gs-3446	213	1	types	type	NOUN
gs-3446	213	2	of	of	ADP
gs-3446	213	3	stem	stem	NOUN
gs-3446	213	4	cells	cell	NOUN
gs-3446	213	5	based	base	VERB
gs-3446	213	6	on	on	ADP
gs-3446	213	7	origin	origin	NOUN
gs-3446	213	8	○	○	ADJ
gs-3446	213	9	embryonic	embryonic	ADJ
gs-3446	213	10	stem	stem	NOUN
gs-3446	213	11	cells	cell	NOUN
gs-3446	213	12	(	(	PUNCT
gs-3446	213	13	escs	esc	NOUN
gs-3446	213	14	):	):	PUNCT
gs-3446	213	15	derived	derive	VERB
gs-3446	213	16	from	from	ADP
gs-3446	213	17	the	the	DET
gs-3446	213	18	inner	inner	ADJ
gs-3446	213	19	cell	cell	NOUN
gs-3446	213	20	mass	mass	NOUN
gs-3446	213	21	of	of	ADP
gs-3446	213	22	the	the	DET
gs-3446	213	23	blastocyst	blastocyst	NOUN
gs-3446	213	24	,	,	PUNCT
gs-3446	213	25	escs	esc	NOUN
gs-3446	213	26	are	be	AUX
gs-3446	213	27	pluripotent	pluripotent	ADJ
gs-3446	213	28	and	and	CCONJ
gs-3446	213	29	hold	hold	VERB
gs-3446	213	30	significant	significant	ADJ
gs-3446	213	31	promise	promise	NOUN
gs-3446	213	32	for	for	ADP
gs-3446	213	33	regenerative	regenerative	ADJ
gs-3446	213	34	medicine	medicine	NOUN
gs-3446	213	35	.	.	PUNCT
gs-3446	214	1	○	○	PROPN
gs-3446	214	2	adult	adult	NOUN
gs-3446	214	3	stem	stem	NOUN
gs-3446	214	4	cells	cell	NOUN
gs-3446	214	5	(	(	PUNCT
gs-3446	214	6	ascs	asc	NOUN
gs-3446	214	7	):	):	PUNCT
gs-3446	214	8	these	these	DET
gs-3446	214	9	stem	stem	NOUN
gs-3446	214	10	cells	cell	NOUN
gs-3446	214	11	reside	reside	VERB
gs-3446	214	12	in	in	ADP
gs-3446	214	13	various	various	ADJ
gs-3446	214	14	tissues	tissue	NOUN
gs-3446	214	15	and	and	CCONJ
gs-3446	214	16	contribute	contribute	VERB
gs-3446	214	17	to	to	ADP
gs-3446	214	18	tissue	tissue	NOUN
gs-3446	214	19	homeostasis	homeostasis	NOUN
gs-3446	214	20	and	and	CCONJ
gs-3446	214	21	repair	repair	NOUN
gs-3446	214	22	.	.	PUNCT
gs-3446	215	1	examples	example	NOUN
gs-3446	215	2	include	include	VERB
gs-3446	215	3	neural	neural	ADJ
gs-3446	215	4	stem	stem	NOUN
gs-3446	215	5	cells	cell	NOUN
gs-3446	215	6	in	in	ADP
gs-3446	215	7	the	the	DET
gs-3446	215	8	brain	brain	NOUN
gs-3446	215	9	and	and	CCONJ
gs-3446	215	10	hematopoietic	hematopoietic	ADJ
gs-3446	215	11	stem	stem	NOUN
gs-3446	215	12	cells	cell	NOUN
gs-3446	215	13	in	in	ADP
gs-3446	215	14	the	the	DET
gs-3446	215	15	bone	bone	NOUN
gs-3446	215	16	marrow	marrow	NOUN
gs-3446	215	17	.	.	PUNCT
gs-3446	216	1	georgian	georgian	ADJ
gs-3446	216	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	216	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	216	4	ტ.	ტ.	VERB
gs-3446	216	5	7	7	NUM
gs-3446	216	6	n	n	PRON
gs-3446	216	7	1	1	NUM
gs-3446	216	8	,	,	PUNCT
gs-3446	216	9	2025	2025	NUM
gs-3446	216	10	284	284	NUM
gs-3446	216	11	○	○	ADJ
gs-3446	216	12	induced	induce	VERB
gs-3446	216	13	pluripotent	pluripotent	ADJ
gs-3446	216	14	stem	stem	NOUN
gs-3446	216	15	cells	cell	NOUN
gs-3446	216	16	(	(	PUNCT
gs-3446	216	17	ipscs	ipsc	NOUN
gs-3446	216	18	):	):	PUNCT
gs-3446	216	19	these	these	PRON
gs-3446	216	20	are	be	AUX
gs-3446	216	21	somatic	somatic	ADJ
gs-3446	216	22	cells	cell	NOUN
gs-3446	216	23	reprogrammed	reprogramme	VERB
gs-3446	216	24	to	to	PART
gs-3446	216	25	exhibit	exhibit	VERB
gs-3446	216	26	pluripotency	pluripotency	NOUN
gs-3446	216	27	through	through	ADP
gs-3446	216	28	genetic	genetic	ADJ
gs-3446	216	29	manipulation	manipulation	NOUN
gs-3446	216	30	,	,	PUNCT
gs-3446	216	31	offering	offer	VERB
gs-3446	216	32	a	a	DET
gs-3446	216	33	promising	promising	ADJ
gs-3446	216	34	alternative	alternative	NOUN
gs-3446	216	35	to	to	PART
gs-3446	216	36	embryonic	embryonic	VERB
gs-3446	216	37	stem	stem	NOUN
gs-3446	216	38	cells	cell	NOUN
gs-3446	216	39	without	without	ADP
gs-3446	216	40	the	the	DET
gs-3446	216	41	associated	associated	ADJ
gs-3446	216	42	ethical	ethical	ADJ
gs-3446	216	43	concerns	concern	NOUN
gs-3446	216	44	.	.	PUNCT
gs-3446	217	1	germ	germ	NOUN
gs-3446	217	2	cells	cell	NOUN
gs-3446	217	3	:	:	PUNCT
gs-3446	217	4	definition	definition	NOUN
gs-3446	217	5	and	and	CCONJ
gs-3446	217	6	development	development	NOUN
gs-3446	217	7	germ	germ	NOUN
gs-3446	217	8	cells	cell	NOUN
gs-3446	217	9	are	be	AUX
gs-3446	217	10	the	the	DET
gs-3446	217	11	precursors	precursor	NOUN
gs-3446	217	12	of	of	ADP
gs-3446	217	13	gametes	gamete	NOUN
gs-3446	217	14	(	(	PUNCT
gs-3446	217	15	sperm	sperm	NOUN
gs-3446	217	16	and	and	CCONJ
gs-3446	217	17	eggs	egg	NOUN
gs-3446	217	18	)	)	PUNCT
gs-3446	217	19	and	and	CCONJ
gs-3446	217	20	play	play	VERB
gs-3446	217	21	a	a	DET
gs-3446	217	22	fundamental	fundamental	ADJ
gs-3446	217	23	role	role	NOUN
gs-3446	217	24	in	in	ADP
gs-3446	217	25	reproduction	reproduction	NOUN
gs-3446	217	26	and	and	CCONJ
gs-3446	217	27	heredity	heredity	NOUN
gs-3446	217	28	.	.	PUNCT
gs-3446	218	1	unlike	unlike	ADP
gs-3446	218	2	somatic	somatic	ADJ
gs-3446	218	3	cells	cell	NOUN
gs-3446	218	4	,	,	PUNCT
gs-3446	218	5	germ	germ	NOUN
gs-3446	218	6	cells	cell	NOUN
gs-3446	218	7	contribute	contribute	VERB
gs-3446	218	8	to	to	ADP
gs-3446	218	9	the	the	DET
gs-3446	218	10	genetic	genetic	ADJ
gs-3446	218	11	continuity	continuity	NOUN
gs-3446	218	12	of	of	ADP
gs-3446	218	13	species	specie	NOUN
gs-3446	218	14	by	by	ADP
gs-3446	218	15	transmitting	transmit	VERB
gs-3446	218	16	genetic	genetic	ADJ
gs-3446	218	17	material	material	NOUN
gs-3446	218	18	across	across	ADP
gs-3446	218	19	generations	generation	NOUN
gs-3446	218	20	.	.	PUNCT
gs-3446	219	1	origin	origin	NOUN
gs-3446	219	2	of	of	ADP
gs-3446	219	3	germ	germ	NOUN
gs-3446	219	4	cells	cell	NOUN
gs-3446	219	5	○	○	ADJ
gs-3446	219	6	germ	germ	NOUN
gs-3446	219	7	cells	cell	NOUN
gs-3446	219	8	arise	arise	VERB
gs-3446	219	9	early	early	ADV
gs-3446	219	10	in	in	ADP
gs-3446	219	11	embryonic	embryonic	ADJ
gs-3446	219	12	development	development	NOUN
gs-3446	219	13	from	from	ADP
gs-3446	219	14	a	a	DET
gs-3446	219	15	small	small	ADJ
gs-3446	219	16	group	group	NOUN
gs-3446	219	17	of	of	ADP
gs-3446	219	18	progenitor	progenitor	NOUN
gs-3446	219	19	cells	cell	NOUN
gs-3446	219	20	known	know	VERB
gs-3446	219	21	as	as	ADP
gs-3446	219	22	primordial	primordial	ADJ
gs-3446	219	23	germ	germ	NOUN
gs-3446	219	24	cells	cell	NOUN
gs-3446	219	25	(	(	PUNCT
gs-3446	219	26	pgcs	pgcs	NOUN
gs-3446	219	27	)	)	PUNCT
gs-3446	219	28	.	.	PUNCT
gs-3446	220	1	these	these	DET
gs-3446	220	2	cells	cell	NOUN
gs-3446	220	3	originate	originate	VERB
gs-3446	220	4	from	from	ADP
gs-3446	220	5	the	the	DET
gs-3446	220	6	epiblast	epiblast	NOUN
gs-3446	220	7	and	and	CCONJ
gs-3446	220	8	migrate	migrate	VERB
gs-3446	220	9	to	to	ADP
gs-3446	220	10	the	the	DET
gs-3446	220	11	developing	develop	VERB
gs-3446	220	12	gonads	gonad	NOUN
gs-3446	220	13	,	,	PUNCT
gs-3446	220	14	where	where	SCONJ
gs-3446	220	15	they	they	PRON
gs-3446	220	16	undergo	undergo	VERB
gs-3446	220	17	further	further	ADJ
gs-3446	220	18	differentiation	differentiation	NOUN
gs-3446	220	19	.	.	PUNCT
gs-3446	221	1	gametogenesis	gametogenesis	NOUN
gs-3446	221	2	:	:	PUNCT
gs-3446	221	3	the	the	DET
gs-3446	221	4	process	process	NOUN
gs-3446	221	5	of	of	ADP
gs-3446	221	6	germ	germ	NOUN
gs-3446	221	7	cell	cell	NOUN
gs-3446	221	8	maturation	maturation	NOUN
gs-3446	221	9	○	○	ADJ
gs-3446	221	10	spermatogenesis	spermatogenesis	NOUN
gs-3446	221	11	:	:	PUNCT
gs-3446	221	12	in	in	ADP
gs-3446	221	13	males	male	NOUN
gs-3446	221	14	,	,	PUNCT
gs-3446	221	15	germ	germ	NOUN
gs-3446	221	16	cells	cell	NOUN
gs-3446	221	17	differentiate	differentiate	VERB
gs-3446	221	18	into	into	ADP
gs-3446	221	19	spermatozoa	spermatozoon	NOUN
gs-3446	221	20	through	through	ADP
gs-3446	221	21	a	a	DET
gs-3446	221	22	tightly	tightly	ADV
gs-3446	221	23	regulated	regulate	VERB
gs-3446	221	24	process	process	NOUN
gs-3446	221	25	involving	involve	VERB
gs-3446	221	26	mitosis	mitosis	NOUN
gs-3446	221	27	,	,	PUNCT
gs-3446	221	28	meiosis	meiosis	NOUN
gs-3446	221	29	,	,	PUNCT
gs-3446	221	30	and	and	CCONJ
gs-3446	221	31	morphological	morphological	ADJ
gs-3446	221	32	changes	change	NOUN
gs-3446	221	33	.	.	PUNCT
gs-3446	222	1	○	○	PROPN
gs-3446	222	2	oogenesis	oogenesis	NOUN
gs-3446	222	3	:	:	PUNCT
gs-3446	222	4	in	in	ADP
gs-3446	222	5	females	female	NOUN
gs-3446	222	6	,	,	PUNCT
gs-3446	222	7	germ	germ	NOUN
gs-3446	222	8	cells	cell	NOUN
gs-3446	222	9	develop	develop	VERB
gs-3446	222	10	into	into	ADP
gs-3446	222	11	oocytes	oocyte	NOUN
gs-3446	222	12	,	,	PUNCT
gs-3446	222	13	which	which	PRON
gs-3446	222	14	are	be	AUX
gs-3446	222	15	arrested	arrest	VERB
gs-3446	222	16	in	in	ADP
gs-3446	222	17	meiosis	meiosis	NOUN
gs-3446	222	18	until	until	ADP
gs-3446	222	19	fertilization	fertilization	NOUN
gs-3446	222	20	.	.	PUNCT
gs-3446	223	1	this	this	DET
gs-3446	223	2	process	process	NOUN
gs-3446	223	3	ensures	ensure	VERB
gs-3446	223	4	the	the	DET
gs-3446	223	5	proper	proper	ADJ
gs-3446	223	6	allocation	allocation	NOUN
gs-3446	223	7	of	of	ADP
gs-3446	223	8	cytoplasmic	cytoplasmic	ADJ
gs-3446	223	9	resources	resource	NOUN
gs-3446	223	10	necessary	necessary	ADJ
gs-3446	223	11	for	for	ADP
gs-3446	223	12	early	early	ADJ
gs-3446	223	13	embryonic	embryonic	ADJ
gs-3446	223	14	development	development	NOUN
gs-3446	223	15	.	.	PUNCT
gs-3446	224	1	unique	unique	ADJ
gs-3446	224	2	properties	property	NOUN
gs-3446	224	3	of	of	ADP
gs-3446	224	4	germ	germ	NOUN
gs-3446	224	5	cells	cell	NOUN
gs-3446	224	6	○	○	ADJ
gs-3446	224	7	germ	germ	NOUN
gs-3446	224	8	cells	cell	NOUN
gs-3446	224	9	undergo	undergo	VERB
gs-3446	224	10	meiosis	meiosis	NOUN
gs-3446	224	11	,	,	PUNCT
gs-3446	224	12	a	a	DET
gs-3446	224	13	specialized	specialized	ADJ
gs-3446	224	14	type	type	NOUN
gs-3446	224	15	of	of	ADP
gs-3446	224	16	cell	cell	NOUN
gs-3446	224	17	division	division	NOUN
gs-3446	224	18	that	that	PRON
gs-3446	224	19	reduces	reduce	VERB
gs-3446	224	20	chromosome	chromosome	NOUN
gs-3446	224	21	numbers	number	NOUN
gs-3446	224	22	by	by	ADP
gs-3446	224	23	half	half	NOUN
gs-3446	224	24	,	,	PUNCT
gs-3446	224	25	ensuring	ensure	VERB
gs-3446	224	26	genetic	genetic	ADJ
gs-3446	224	27	diversity	diversity	NOUN
gs-3446	224	28	through	through	ADP
gs-3446	224	29	recombination	recombination	NOUN
gs-3446	224	30	and	and	CCONJ
gs-3446	224	31	independent	independent	ADJ
gs-3446	224	32	assortment	assortment	NOUN
gs-3446	224	33	.	.	PUNCT
gs-3446	225	1	○	○	ADJ
gs-3446	225	2	unlike	unlike	ADP
gs-3446	225	3	most	most	ADJ
gs-3446	225	4	somatic	somatic	ADJ
gs-3446	225	5	cells	cell	NOUN
gs-3446	225	6	,	,	PUNCT
gs-3446	225	7	germ	germ	NOUN
gs-3446	225	8	cells	cell	NOUN
gs-3446	225	9	are	be	AUX
gs-3446	225	10	totipotent	totipotent	ADJ
gs-3446	225	11	at	at	ADP
gs-3446	225	12	the	the	DET
gs-3446	225	13	zygotic	zygotic	ADJ
gs-3446	225	14	stage	stage	NOUN
gs-3446	225	15	,	,	PUNCT
gs-3446	225	16	capable	capable	ADJ
gs-3446	225	17	of	of	ADP
gs-3446	225	18	giving	give	VERB
gs-3446	225	19	rise	rise	NOUN
gs-3446	225	20	to	to	ADP
gs-3446	225	21	an	an	DET
gs-3446	225	22	entire	entire	ADJ
gs-3446	225	23	organism	organism	NOUN
gs-3446	225	24	(	(	PUNCT
gs-3446	225	25	saitou	saitou	NOUN
gs-3446	225	26	et	et	PROPN
gs-3446	225	27	al	al	PROPN
gs-3446	225	28	.	.	PROPN
gs-3446	225	29	2012	2012	NUM
gs-3446	225	30	)	)	PUNCT
gs-3446	225	31	.	.	PUNCT
gs-3446	226	1	significance	significance	NOUN
gs-3446	226	2	in	in	ADP
gs-3446	226	3	medical	medical	ADJ
gs-3446	226	4	and	and	CCONJ
gs-3446	226	5	scientific	scientific	ADJ
gs-3446	226	6	research	research	NOUN
gs-3446	226	7	the	the	DET
gs-3446	226	8	study	study	NOUN
gs-3446	226	9	of	of	ADP
gs-3446	226	10	stem	stem	NOUN
gs-3446	226	11	cells	cell	NOUN
gs-3446	226	12	and	and	CCONJ
gs-3446	226	13	germ	germ	NOUN
gs-3446	226	14	cells	cell	NOUN
gs-3446	226	15	holds	hold	VERB
gs-3446	226	16	immense	immense	ADJ
gs-3446	226	17	potential	potential	NOUN
gs-3446	226	18	for	for	ADP
gs-3446	226	19	medical	medical	ADJ
gs-3446	226	20	applications	application	NOUN
gs-3446	226	21	.	.	PUNCT
gs-3446	227	1	stem	stem	NOUN
gs-3446	227	2	cell	cell	NOUN
gs-3446	227	3	therapy	therapy	NOUN
gs-3446	227	4	offers	offer	VERB
gs-3446	227	5	promising	promise	VERB
gs-3446	227	6	solutions	solution	NOUN
gs-3446	227	7	for	for	ADP
gs-3446	227	8	treating	treat	VERB
gs-3446	227	9	degenerative	degenerative	ADJ
gs-3446	227	10	diseases	disease	NOUN
gs-3446	227	11	such	such	ADJ
gs-3446	227	12	as	as	ADP
gs-3446	227	13	parkinson	parkinson	NOUN
gs-3446	227	14	’s	’s	PART
gs-3446	227	15	,	,	PUNCT
gs-3446	227	16	alzheimer	alzheimer	PROPN
gs-3446	227	17	’s	’s	PART
gs-3446	227	18	,	,	PUNCT
gs-3446	227	19	and	and	CCONJ
gs-3446	227	20	diabetes	diabetes	NOUN
gs-3446	227	21	.	.	PUNCT
gs-3446	228	1	germ	germ	NOUN
gs-3446	228	2	cell	cell	NOUN
gs-3446	228	3	research	research	NOUN
gs-3446	228	4	contributes	contribute	VERB
gs-3446	228	5	to	to	ADP
gs-3446	228	6	the	the	DET
gs-3446	228	7	understanding	understanding	NOUN
gs-3446	228	8	and	and	CCONJ
gs-3446	228	9	treatment	treatment	NOUN
gs-3446	228	10	of	of	ADP
gs-3446	228	11	infertility	infertility	NOUN
gs-3446	228	12	,	,	PUNCT
gs-3446	228	13	reproductive	reproductive	ADJ
gs-3446	228	14	disorders	disorder	NOUN
gs-3446	228	15	,	,	PUNCT
gs-3446	228	16	and	and	CCONJ
gs-3446	228	17	hereditary	hereditary	ADJ
gs-3446	228	18	diseases	disease	NOUN
gs-3446	228	19	.	.	PUNCT
gs-3446	229	1	additionally	additionally	ADV
gs-3446	229	2	,	,	PUNCT
gs-3446	229	3	the	the	DET
gs-3446	229	4	ability	ability	NOUN
gs-3446	229	5	to	to	PART
gs-3446	229	6	generate	generate	VERB
gs-3446	229	7	gametes	gamete	NOUN
gs-3446	229	8	from	from	ADP
gs-3446	229	9	stem	stem	NOUN
gs-3446	229	10	cells	cell	NOUN
gs-3446	229	11	raises	raise	VERB
gs-3446	229	12	possibilities	possibility	NOUN
gs-3446	229	13	for	for	ADP
gs-3446	229	14	novel	novel	ADJ
gs-3446	229	15	reproductive	reproductive	ADJ
gs-3446	229	16	technologies	technology	NOUN
gs-3446	229	17	.	.	PUNCT
gs-3446	230	1	however	however	ADV
gs-3446	230	2	,	,	PUNCT
gs-3446	230	3	these	these	DET
gs-3446	230	4	advancements	advancement	NOUN
gs-3446	230	5	come	come	VERB
gs-3446	230	6	with	with	ADP
gs-3446	230	7	ethical	ethical	ADJ
gs-3446	230	8	challenges	challenge	NOUN
gs-3446	230	9	,	,	PUNCT
gs-3446	230	10	particularly	particularly	ADV
gs-3446	230	11	concerning	concern	VERB
gs-3446	230	12	embryonic	embryonic	ADJ
gs-3446	230	13	stem	stem	NOUN
gs-3446	230	14	cell	cell	NOUN
gs-3446	230	15	research	research	NOUN
gs-3446	230	16	and	and	CCONJ
gs-3446	230	17	genetic	genetic	ADJ
gs-3446	230	18	modifications	modification	NOUN
gs-3446	230	19	.	.	PUNCT
gs-3446	231	1	regulatory	regulatory	ADJ
gs-3446	231	2	frameworks	framework	NOUN
gs-3446	231	3	continue	continue	VERB
gs-3446	231	4	to	to	PART
gs-3446	231	5	evolve	evolve	VERB
gs-3446	231	6	to	to	PART
gs-3446	231	7	balance	balance	VERB
gs-3446	231	8	scientific	scientific	ADJ
gs-3446	231	9	progress	progress	NOUN
gs-3446	231	10	with	with	ADP
gs-3446	231	11	ethical	ethical	ADJ
gs-3446	231	12	considerations	consideration	NOUN
gs-3446	231	13	.	.	PUNCT
gs-3446	232	1	georgian	georgian	ADJ
gs-3446	232	2	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3446	232	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	232	4	ტ.	ტ.	VERB
gs-3446	232	5	7	7	NUM
gs-3446	232	6	n	n	PRON
gs-3446	232	7	1	1	NUM
gs-3446	232	8	,	,	PUNCT
gs-3446	232	9	2025	2025	NUM
gs-3446	232	10	285	285	NUM
gs-3446	232	11	stem	stem	NOUN
gs-3446	232	12	cells	cell	NOUN
gs-3446	232	13	and	and	CCONJ
gs-3446	232	14	germ	germ	NOUN
gs-3446	232	15	cells	cell	NOUN
gs-3446	232	16	are	be	AUX
gs-3446	232	17	indispensable	indispensable	ADJ
gs-3446	232	18	components	component	NOUN
gs-3446	232	19	of	of	ADP
gs-3446	232	20	biological	biological	ADJ
gs-3446	232	21	development	development	NOUN
gs-3446	232	22	and	and	CCONJ
gs-3446	232	23	regeneration	regeneration	NOUN
gs-3446	232	24	.	.	PUNCT
gs-3446	233	1	their	their	PRON
gs-3446	233	2	unique	unique	ADJ
gs-3446	233	3	abilities	ability	NOUN
gs-3446	233	4	to	to	PART
gs-3446	233	5	differentiate	differentiate	VERB
gs-3446	233	6	and	and	CCONJ
gs-3446	233	7	self	self	NOUN
gs-3446	233	8	-	-	PUNCT
gs-3446	233	9	renew	renew	NOUN
gs-3446	233	10	make	make	VERB
gs-3446	233	11	them	they	PRON
gs-3446	233	12	critical	critical	ADJ
gs-3446	233	13	for	for	ADP
gs-3446	233	14	tissue	tissue	NOUN
gs-3446	233	15	maintenance	maintenance	NOUN
gs-3446	233	16	,	,	PUNCT
gs-3446	233	17	repair	repair	NOUN
gs-3446	233	18	,	,	PUNCT
gs-3446	233	19	and	and	CCONJ
gs-3446	233	20	reproduction	reproduction	NOUN
gs-3446	233	21	.	.	PUNCT
gs-3446	234	1	understanding	understand	VERB
gs-3446	234	2	these	these	DET
gs-3446	234	3	cells	cell	NOUN
gs-3446	234	4	'	'	PART
gs-3446	234	5	fundamental	fundamental	ADJ
gs-3446	234	6	properties	property	NOUN
gs-3446	234	7	and	and	CCONJ
gs-3446	234	8	interactions	interaction	NOUN
gs-3446	234	9	enhances	enhance	VERB
gs-3446	234	10	our	our	PRON
gs-3446	234	11	capacity	capacity	NOUN
gs-3446	234	12	to	to	PART
gs-3446	234	13	develop	develop	VERB
gs-3446	234	14	novel	novel	ADJ
gs-3446	234	15	medical	medical	ADJ
gs-3446	234	16	therapies	therapy	NOUN
gs-3446	234	17	and	and	CCONJ
gs-3446	234	18	address	address	VERB
gs-3446	234	19	fertility	fertility	NOUN
gs-3446	234	20	-	-	PUNCT
gs-3446	234	21	related	relate	VERB
gs-3446	234	22	issues	issue	NOUN
gs-3446	234	23	.	.	PUNCT
gs-3446	235	1	as	as	SCONJ
gs-3446	235	2	research	research	NOUN
gs-3446	235	3	advances	advance	NOUN
gs-3446	235	4	,	,	PUNCT
gs-3446	235	5	the	the	DET
gs-3446	235	6	ethical	ethical	ADJ
gs-3446	235	7	and	and	CCONJ
gs-3446	235	8	scientific	scientific	ADJ
gs-3446	235	9	discourse	discourse	NOUN
gs-3446	235	10	surrounding	surround	VERB
gs-3446	235	11	their	their	PRON
gs-3446	235	12	use	use	NOUN
gs-3446	235	13	will	will	AUX
gs-3446	235	14	remain	remain	VERB
gs-3446	235	15	crucial	crucial	ADJ
gs-3446	235	16	in	in	ADP
gs-3446	235	17	shaping	shape	VERB
gs-3446	235	18	the	the	DET
gs-3446	235	19	future	future	NOUN
gs-3446	235	20	of	of	ADP
gs-3446	235	21	regenerative	regenerative	ADJ
gs-3446	235	22	and	and	CCONJ
gs-3446	235	23	reproductive	reproductive	ADJ
gs-3446	235	24	medicine	medicine	NOUN
gs-3446	235	25	.	.	PUNCT
gs-3446	236	1	stem	stem	NOUN
gs-3446	236	2	cells	cell	NOUN
gs-3446	236	3	heterogeneity	heterogeneity	NOUN
gs-3446	236	4	:	:	PUNCT
gs-3446	236	5	transcriptional	transcriptional	ADJ
gs-3446	236	6	circuits	circuit	NOUN
gs-3446	236	7	in	in	ADP
gs-3446	236	8	pluripotent	pluripotent	ADJ
gs-3446	236	9	,	,	PUNCT
gs-3446	236	10	multipotency	multipotency	NOUN
gs-3446	236	11	,	,	PUNCT
gs-3446	236	12	unipotency	unipotency	NOUN
gs-3446	236	13	stem	stem	NOUN
gs-3446	236	14	cells	cell	NOUN
gs-3446	236	15	are	be	AUX
gs-3446	236	16	defined	define	VERB
gs-3446	236	17	by	by	ADP
gs-3446	236	18	their	their	PRON
gs-3446	236	19	ability	ability	NOUN
gs-3446	236	20	to	to	PART
gs-3446	236	21	self	self	NOUN
gs-3446	236	22	-	-	PUNCT
gs-3446	236	23	renew	renew	VERB
gs-3446	236	24	and	and	CCONJ
gs-3446	236	25	differentiate	differentiate	VERB
gs-3446	236	26	into	into	ADP
gs-3446	236	27	various	various	ADJ
gs-3446	236	28	cell	cell	NOUN
gs-3446	236	29	types	type	NOUN
gs-3446	236	30	,	,	PUNCT
gs-3446	236	31	making	make	VERB
gs-3446	236	32	them	they	PRON
gs-3446	236	33	fundamental	fundamental	ADJ
gs-3446	236	34	for	for	ADP
gs-3446	236	35	development	development	NOUN
gs-3446	236	36	,	,	PUNCT
gs-3446	236	37	tissue	tissue	NOUN
gs-3446	236	38	homeostasis	homeostasis	NOUN
gs-3446	236	39	,	,	PUNCT
gs-3446	236	40	and	and	CCONJ
gs-3446	236	41	regenerative	regenerative	ADJ
gs-3446	236	42	medicine	medicine	NOUN
gs-3446	236	43	.	.	PUNCT
gs-3446	237	1	however	however	ADV
gs-3446	237	2	,	,	PUNCT
gs-3446	237	3	stem	stem	NOUN
gs-3446	237	4	cell	cell	NOUN
gs-3446	237	5	populations	population	NOUN
gs-3446	237	6	are	be	AUX
gs-3446	237	7	not	not	PART
gs-3446	237	8	homogeneous	homogeneous	ADJ
gs-3446	237	9	;	;	PUNCT
gs-3446	237	10	they	they	PRON
gs-3446	237	11	exhibit	exhibit	VERB
gs-3446	237	12	significant	significant	ADJ
gs-3446	237	13	heterogeneity	heterogeneity	NOUN
gs-3446	237	14	influenced	influence	VERB
gs-3446	237	15	by	by	ADP
gs-3446	237	16	intrinsic	intrinsic	ADJ
gs-3446	237	17	transcriptional	transcriptional	NOUN
gs-3446	237	18	networks	network	NOUN
gs-3446	237	19	and	and	CCONJ
gs-3446	237	20	extrinsic	extrinsic	ADJ
gs-3446	237	21	environmental	environmental	ADJ
gs-3446	237	22	factors	factor	NOUN
gs-3446	237	23	.	.	PUNCT
gs-3446	238	1	this	this	DET
gs-3446	238	2	heterogeneity	heterogeneity	NOUN
gs-3446	238	3	is	be	AUX
gs-3446	238	4	evident	evident	ADJ
gs-3446	238	5	across	across	ADP
gs-3446	238	6	the	the	DET
gs-3446	238	7	spectrum	spectrum	NOUN
gs-3446	238	8	of	of	ADP
gs-3446	238	9	stem	stem	NOUN
gs-3446	238	10	cell	cell	NOUN
gs-3446	238	11	potency	potency	NOUN
gs-3446	238	12	,	,	PUNCT
gs-3446	238	13	from	from	ADP
gs-3446	238	14	pluripotent	pluripotent	ADJ
gs-3446	238	15	stem	stem	NOUN
gs-3446	238	16	cells	cell	NOUN
gs-3446	238	17	(	(	PUNCT
gs-3446	238	18	pscs	psc	NOUN
gs-3446	238	19	)	)	PUNCT
gs-3446	238	20	,	,	PUNCT
gs-3446	238	21	which	which	PRON
gs-3446	238	22	can	can	AUX
gs-3446	238	23	generate	generate	VERB
gs-3446	238	24	all	all	DET
gs-3446	238	25	embryonic	embryonic	ADJ
gs-3446	238	26	cell	cell	NOUN
gs-3446	238	27	types	type	NOUN
gs-3446	238	28	,	,	PUNCT
gs-3446	238	29	to	to	PART
gs-3446	238	30	multipotent	multipotent	VERB
gs-3446	238	31	and	and	CCONJ
gs-3446	238	32	unipotent	unipotent	ADJ
gs-3446	238	33	stem	stem	NOUN
gs-3446	238	34	cells	cell	NOUN
gs-3446	238	35	,	,	PUNCT
gs-3446	238	36	which	which	PRON
gs-3446	238	37	have	have	AUX
gs-3446	238	38	progressively	progressively	ADV
gs-3446	238	39	restricted	restrict	VERB
gs-3446	238	40	lineage	lineage	NOUN
gs-3446	238	41	potential	potential	NOUN
gs-3446	238	42	(	(	PUNCT
gs-3446	238	43	liska	liska	NOUN
gs-3446	238	44	et	et	PROPN
gs-3446	238	45	al	al	PROPN
gs-3446	238	46	.	.	PROPN
gs-3446	238	47	2017	2017	NUM
gs-3446	238	48	)	)	PUNCT
gs-3446	238	49	.	.	PUNCT
gs-3446	239	1	the	the	DET
gs-3446	239	2	regulatory	regulatory	ADJ
gs-3446	239	3	mechanisms	mechanism	NOUN
gs-3446	239	4	that	that	PRON
gs-3446	239	5	govern	govern	VERB
gs-3446	239	6	stem	stem	NOUN
gs-3446	239	7	cell	cell	NOUN
gs-3446	239	8	potency	potency	NOUN
gs-3446	239	9	involve	involve	VERB
gs-3446	239	10	complex	complex	ADJ
gs-3446	239	11	transcriptional	transcriptional	ADJ
gs-3446	239	12	circuits	circuit	NOUN
gs-3446	239	13	,	,	PUNCT
gs-3446	239	14	including	include	VERB
gs-3446	239	15	core	core	NOUN
gs-3446	239	16	transcription	transcription	NOUN
gs-3446	239	17	factors	factor	NOUN
gs-3446	239	18	,	,	PUNCT
gs-3446	239	19	epigenetic	epigenetic	ADJ
gs-3446	239	20	modifications	modification	NOUN
gs-3446	239	21	,	,	PUNCT
gs-3446	239	22	and	and	CCONJ
gs-3446	239	23	signaling	signal	VERB
gs-3446	239	24	pathways	pathway	NOUN
gs-3446	239	25	.	.	PUNCT
gs-3446	240	1	in	in	ADP
gs-3446	240	2	pluripotent	pluripotent	ADJ
gs-3446	240	3	stem	stem	NOUN
gs-3446	240	4	cells	cell	NOUN
gs-3446	240	5	,	,	PUNCT
gs-3446	240	6	networks	network	NOUN
gs-3446	240	7	centered	center	VERB
gs-3446	240	8	around	around	ADP
gs-3446	240	9	oct4	oct4	PROPN
gs-3446	240	10	,	,	PUNCT
gs-3446	240	11	sox2	sox2	NOUN
gs-3446	240	12	,	,	PUNCT
gs-3446	240	13	and	and	CCONJ
gs-3446	240	14	nanog	nanog	PROPN
gs-3446	240	15	maintain	maintain	VERB
gs-3446	240	16	an	an	DET
gs-3446	240	17	undifferentiated	undifferentiated	ADJ
gs-3446	240	18	state	state	NOUN
gs-3446	240	19	,	,	PUNCT
gs-3446	240	20	while	while	SCONJ
gs-3446	240	21	multipotent	multipotent	NOUN
gs-3446	240	22	and	and	CCONJ
gs-3446	240	23	unipotent	unipotent	ADJ
gs-3446	240	24	stem	stem	NOUN
gs-3446	240	25	cells	cell	NOUN
gs-3446	240	26	rely	rely	VERB
gs-3446	240	27	on	on	ADP
gs-3446	240	28	distinct	distinct	ADJ
gs-3446	240	29	,	,	PUNCT
gs-3446	240	30	lineage	lineage	NOUN
gs-3446	240	31	-	-	PUNCT
gs-3446	240	32	specific	specific	ADJ
gs-3446	240	33	transcriptional	transcriptional	NOUN
gs-3446	240	34	programs	program	NOUN
gs-3446	240	35	.	.	PUNCT
gs-3446	241	1	understanding	understand	VERB
gs-3446	241	2	the	the	DET
gs-3446	241	3	transcriptional	transcriptional	ADJ
gs-3446	241	4	heterogeneity	heterogeneity	NOUN
gs-3446	241	5	within	within	ADP
gs-3446	241	6	these	these	DET
gs-3446	241	7	stem	stem	NOUN
gs-3446	241	8	cell	cell	NOUN
gs-3446	241	9	states	state	NOUN
gs-3446	241	10	is	be	AUX
gs-3446	241	11	critical	critical	ADJ
gs-3446	241	12	for	for	ADP
gs-3446	241	13	advancing	advance	VERB
gs-3446	241	14	regenerative	regenerative	ADJ
gs-3446	241	15	medicine	medicine	NOUN
gs-3446	241	16	,	,	PUNCT
gs-3446	241	17	improving	improve	VERB
gs-3446	241	18	cell	cell	NOUN
gs-3446	241	19	-	-	PUNCT
gs-3446	241	20	based	base	VERB
gs-3446	241	21	therapies	therapy	NOUN
gs-3446	241	22	,	,	PUNCT
gs-3446	241	23	and	and	CCONJ
gs-3446	241	24	elucidating	elucidating	NOUN
gs-3446	241	25	disease	disease	NOUN
gs-3446	241	26	mechanisms	mechanism	NOUN
gs-3446	241	27	(	(	PUNCT
gs-3446	241	28	zare	zare	PROPN
gs-3446	241	29	et	et	PROPN
gs-3446	241	30	al	al	PROPN
gs-3446	241	31	.	.	PROPN
gs-3446	241	32	2023	2023	NUM
gs-3446	241	33	)	)	PUNCT
gs-3446	241	34	.	.	PUNCT
gs-3446	242	1	this	this	DET
gs-3446	242	2	review	review	NOUN
gs-3446	242	3	explores	explore	VERB
gs-3446	242	4	the	the	DET
gs-3446	242	5	transcriptional	transcriptional	ADJ
gs-3446	242	6	heterogeneity	heterogeneity	NOUN
gs-3446	242	7	in	in	ADP
gs-3446	242	8	stem	stem	NOUN
gs-3446	242	9	cell	cell	NOUN
gs-3446	242	10	populations	population	NOUN
gs-3446	242	11	by	by	ADP
gs-3446	242	12	examining	examine	VERB
gs-3446	242	13	key	key	ADJ
gs-3446	242	14	transcriptional	transcriptional	ADJ
gs-3446	242	15	regulators	regulator	NOUN
gs-3446	242	16	and	and	CCONJ
gs-3446	242	17	their	their	PRON
gs-3446	242	18	functional	functional	ADJ
gs-3446	242	19	interplay	interplay	NOUN
gs-3446	242	20	across	across	ADP
gs-3446	242	21	pluripotent	pluripotent	NOUN
gs-3446	242	22	,	,	PUNCT
gs-3446	242	23	multipotent	multipotent	NOUN
gs-3446	242	24	,	,	PUNCT
gs-3446	242	25	and	and	CCONJ
gs-3446	242	26	unipotent	unipotent	ADJ
gs-3446	242	27	states	state	NOUN
gs-3446	242	28	.	.	PUNCT
gs-3446	243	1	we	we	PRON
gs-3446	243	2	discuss	discuss	VERB
gs-3446	243	3	how	how	SCONJ
gs-3446	243	4	transcriptional	transcriptional	ADJ
gs-3446	243	5	circuits	circuit	NOUN
gs-3446	243	6	influence	influence	NOUN
gs-3446	243	7	cell	cell	NOUN
gs-3446	243	8	fate	fate	NOUN
gs-3446	243	9	decisions	decision	NOUN
gs-3446	243	10	and	and	CCONJ
gs-3446	243	11	how	how	SCONJ
gs-3446	243	12	this	this	DET
gs-3446	243	13	knowledge	knowledge	NOUN
gs-3446	243	14	can	can	AUX
gs-3446	243	15	be	be	AUX
gs-3446	243	16	leveraged	leverage	VERB
gs-3446	243	17	for	for	ADP
gs-3446	243	18	therapeutic	therapeutic	ADJ
gs-3446	243	19	applications	application	NOUN
gs-3446	243	20	.	.	PUNCT
gs-3446	244	1	the	the	DET
gs-3446	244	2	heterogeneity	heterogeneity	NOUN
gs-3446	244	3	observed	observe	VERB
gs-3446	244	4	in	in	ADP
gs-3446	244	5	stem	stem	NOUN
gs-3446	244	6	cell	cell	NOUN
gs-3446	244	7	populations	population	NOUN
gs-3446	244	8	is	be	AUX
gs-3446	244	9	driven	drive	VERB
gs-3446	244	10	by	by	ADP
gs-3446	244	11	intricate	intricate	ADJ
gs-3446	244	12	transcriptional	transcriptional	ADJ
gs-3446	244	13	networks	network	NOUN
gs-3446	244	14	that	that	SCONJ
gs-3446	244	15	fine	fine	ADJ
gs-3446	244	16	-	-	PUNCT
gs-3446	244	17	tune	tune	NOUN
gs-3446	244	18	their	their	PRON
gs-3446	244	19	functional	functional	ADJ
gs-3446	244	20	states	state	NOUN
gs-3446	244	21	.	.	PUNCT
gs-3446	245	1	in	in	ADP
gs-3446	245	2	pluripotent	pluripotent	ADJ
gs-3446	245	3	stem	stem	NOUN
gs-3446	245	4	cells	cell	NOUN
gs-3446	245	5	,	,	PUNCT
gs-3446	245	6	the	the	DET
gs-3446	245	7	dynamic	dynamic	ADJ
gs-3446	245	8	expression	expression	NOUN
gs-3446	245	9	of	of	ADP
gs-3446	245	10	core	core	NOUN
gs-3446	245	11	transcription	transcription	NOUN
gs-3446	245	12	factors	factor	NOUN
gs-3446	245	13	such	such	ADJ
gs-3446	245	14	as	as	ADP
gs-3446	245	15	oct4	oct4	NOUN
gs-3446	245	16	,	,	PUNCT
gs-3446	245	17	sox2	sox2	NOUN
gs-3446	245	18	,	,	PUNCT
gs-3446	245	19	and	and	CCONJ
gs-3446	245	20	nanog	nanog	PROPN
gs-3446	245	21	allows	allow	VERB
gs-3446	245	22	for	for	ADP
gs-3446	245	23	cellular	cellular	ADJ
gs-3446	245	24	plasticity	plasticity	NOUN
gs-3446	245	25	,	,	PUNCT
gs-3446	245	26	enabling	enable	VERB
gs-3446	245	27	differentiation	differentiation	NOUN
gs-3446	245	28	into	into	ADP
gs-3446	245	29	multiple	multiple	ADJ
gs-3446	245	30	lineages	lineage	NOUN
gs-3446	245	31	.	.	PUNCT
gs-3446	246	1	however	however	ADV
gs-3446	246	2	,	,	PUNCT
gs-3446	246	3	single	single	ADJ
gs-3446	246	4	-	-	PUNCT
gs-3446	246	5	cell	cell	NOUN
gs-3446	246	6	transcriptomic	transcriptomic	ADJ
gs-3446	246	7	analyses	analysis	NOUN
gs-3446	246	8	have	have	AUX
gs-3446	246	9	revealed	reveal	VERB
gs-3446	246	10	that	that	SCONJ
gs-3446	246	11	even	even	ADV
gs-3446	246	12	within	within	ADP
gs-3446	246	13	psc	psc	PROPN
gs-3446	246	14	cultures	culture	NOUN
gs-3446	246	15	,	,	PUNCT
gs-3446	246	16	subpopulations	subpopulation	NOUN
gs-3446	246	17	exist	exist	VERB
gs-3446	246	18	with	with	ADP
gs-3446	246	19	distinct	distinct	ADJ
gs-3446	246	20	transcriptional	transcriptional	ADJ
gs-3446	246	21	signatures	signature	NOUN
gs-3446	246	22	,	,	PUNCT
gs-3446	246	23	indicating	indicate	VERB
gs-3446	246	24	a	a	DET
gs-3446	246	25	spectrum	spectrum	NOUN
gs-3446	246	26	of	of	ADP
gs-3446	246	27	pluripotency	pluripotency	ADJ
gs-3446	246	28	states	state	NOUN
gs-3446	246	29	that	that	PRON
gs-3446	246	30	may	may	AUX
gs-3446	246	31	affect	affect	VERB
gs-3446	246	32	differentiation	differentiation	NOUN
gs-3446	246	33	efficiency	efficiency	NOUN
gs-3446	246	34	.	.	PUNCT
gs-3446	247	1	multipotent	multipotent	NOUN
gs-3446	247	2	stem	stem	NOUN
gs-3446	247	3	cells	cell	NOUN
gs-3446	247	4	,	,	PUNCT
gs-3446	247	5	such	such	ADJ
gs-3446	247	6	as	as	ADP
gs-3446	247	7	mesenchymal	mesenchymal	ADJ
gs-3446	247	8	stem	stem	NOUN
gs-3446	247	9	cells	cell	NOUN
gs-3446	247	10	(	(	PUNCT
gs-3446	247	11	mscs	msc	NOUN
gs-3446	247	12	)	)	PUNCT
gs-3446	247	13	and	and	CCONJ
gs-3446	247	14	hematopoietic	hematopoietic	ADJ
gs-3446	247	15	stem	stem	NOUN
gs-3446	247	16	cells	cell	NOUN
gs-3446	247	17	(	(	PUNCT
gs-3446	247	18	hscs	hsc	NOUN
gs-3446	247	19	)	)	PUNCT
gs-3446	247	20	,	,	PUNCT
gs-3446	247	21	exhibit	exhibit	VERB
gs-3446	247	22	transcriptional	transcriptional	ADJ
gs-3446	247	23	diversity	diversity	NOUN
gs-3446	247	24	dictated	dictate	VERB
gs-3446	247	25	by	by	ADP
gs-3446	247	26	tissue	tissue	NOUN
gs-3446	247	27	-	-	PUNCT
gs-3446	247	28	specific	specific	ADJ
gs-3446	247	29	transcription	transcription	NOUN
gs-3446	247	30	factors	factor	NOUN
gs-3446	247	31	,	,	PUNCT
gs-3446	247	32	epigenetic	epigenetic	ADJ
gs-3446	247	33	regulators	regulator	NOUN
gs-3446	247	34	,	,	PUNCT
gs-3446	247	35	and	and	CCONJ
gs-3446	247	36	niche	niche	NOUN
gs-3446	247	37	signals	signal	NOUN
gs-3446	247	38	.	.	PUNCT
gs-3446	248	1	for	for	ADP
gs-3446	248	2	example	example	NOUN
gs-3446	248	3	,	,	PUNCT
gs-3446	248	4	hsc	hsc	PROPN
gs-3446	248	5	fate	fate	NOUN
gs-3446	248	6	is	be	AUX
gs-3446	248	7	governed	govern	VERB
gs-3446	248	8	by	by	ADP
gs-3446	248	9	a	a	DET
gs-3446	248	10	balance	balance	NOUN
gs-3446	248	11	between	between	ADP
gs-3446	248	12	self	self	NOUN
gs-3446	248	13	-	-	PUNCT
gs-3446	248	14	renewal	renewal	NOUN
gs-3446	248	15	factors	factor	NOUN
gs-3446	248	16	(	(	PUNCT
gs-3446	248	17	e.g.	e.g.	ADV
gs-3446	248	18	,	,	PUNCT
gs-3446	248	19	runx1	runx1	NOUN
gs-3446	248	20	,	,	PUNCT
gs-3446	248	21	gata2	gata2	PROPN
gs-3446	248	22	)	)	PUNCT
gs-3446	248	23	and	and	CCONJ
gs-3446	248	24	differentiation	differentiation	NOUN
gs-3446	248	25	cues	cue	NOUN
gs-3446	248	26	,	,	PUNCT
gs-3446	248	27	ensuring	ensure	VERB
gs-3446	248	28	proper	proper	ADJ
gs-3446	248	29	hematopoiesis	hematopoiesis	NOUN
gs-3446	248	30	.	.	PUNCT
gs-3446	249	1	similarly	similarly	ADV
gs-3446	249	2	,	,	PUNCT
gs-3446	249	3	mscs	msc	NOUN
gs-3446	249	4	rely	rely	VERB
gs-3446	249	5	on	on	ADP
gs-3446	249	6	transcriptional	transcriptional	ADJ
gs-3446	249	7	regulators	regulator	NOUN
gs-3446	249	8	like	like	ADP
gs-3446	249	9	sox9	sox9	PROPN
gs-3446	249	10	and	and	CCONJ
gs-3446	249	11	pparγ	pparγ	ADJ
gs-3446	249	12	to	to	PART
gs-3446	249	13	dictate	dictate	VERB
gs-3446	249	14	lineage	lineage	NOUN
gs-3446	249	15	commitment	commitment	NOUN
gs-3446	249	16	toward	toward	ADP
gs-3446	249	17	osteogenic	osteogenic	ADJ
gs-3446	249	18	,	,	PUNCT
gs-3446	249	19	chondrogenic	chondrogenic	ADJ
gs-3446	249	20	,	,	PUNCT
gs-3446	249	21	or	or	CCONJ
gs-3446	249	22	adipogenic	adipogenic	ADJ
gs-3446	249	23	fates	fate	NOUN
gs-3446	249	24	.	.	PUNCT
gs-3446	250	1	the	the	DET
gs-3446	250	2	heterogeneity	heterogeneity	NOUN
gs-3446	250	3	in	in	ADP
gs-3446	250	4	these	these	DET
gs-3446	250	5	populations	population	NOUN
gs-3446	250	6	reflects	reflect	VERB
gs-3446	250	7	functional	functional	ADJ
gs-3446	250	8	georgian	georgian	ADJ
gs-3446	250	9	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3446	250	10	მეცნიერები	მეცნიერები	NOUN
gs-3446	250	11	ტ.	ტ.	VERB
gs-3446	250	12	7	7	NUM
gs-3446	250	13	n	n	PRON
gs-3446	250	14	1	1	NUM
gs-3446	250	15	,	,	PUNCT
gs-3446	250	16	2025	2025	NUM
gs-3446	250	17	286	286	NUM
gs-3446	250	18	adaptability	adaptability	NOUN
gs-3446	250	19	but	but	CCONJ
gs-3446	250	20	also	also	ADV
gs-3446	250	21	poses	pose	VERB
gs-3446	250	22	challenges	challenge	NOUN
gs-3446	250	23	for	for	ADP
gs-3446	250	24	therapeutic	therapeutic	ADJ
gs-3446	250	25	applications	application	NOUN
gs-3446	250	26	,	,	PUNCT
gs-3446	250	27	where	where	SCONJ
gs-3446	250	28	standardized	standardized	ADJ
gs-3446	250	29	cell	cell	NOUN
gs-3446	250	30	populations	population	NOUN
gs-3446	250	31	are	be	AUX
gs-3446	250	32	desirable	desirable	ADJ
gs-3446	250	33	(	(	PUNCT
gs-3446	250	34	zare	zare	PROPN
gs-3446	250	35	et	et	PROPN
gs-3446	250	36	al	al	PROPN
gs-3446	250	37	.	.	PROPN
gs-3446	250	38	2023	2023	NUM
gs-3446	250	39	)	)	PUNCT
gs-3446	250	40	.	.	PUNCT
gs-3446	251	1	in	in	ADP
gs-3446	251	2	contrast	contrast	NOUN
gs-3446	251	3	,	,	PUNCT
gs-3446	251	4	unipotent	unipotent	ADJ
gs-3446	251	5	stem	stem	NOUN
gs-3446	251	6	cells	cell	NOUN
gs-3446	251	7	,	,	PUNCT
gs-3446	251	8	which	which	PRON
gs-3446	251	9	primarily	primarily	ADV
gs-3446	251	10	give	give	VERB
gs-3446	251	11	rise	rise	NOUN
gs-3446	251	12	to	to	ADP
gs-3446	251	13	a	a	DET
gs-3446	251	14	single	single	ADJ
gs-3446	251	15	cell	cell	NOUN
gs-3446	251	16	type	type	NOUN
gs-3446	251	17	,	,	PUNCT
gs-3446	251	18	such	such	ADJ
gs-3446	251	19	as	as	ADP
gs-3446	251	20	epidermal	epidermal	ADJ
gs-3446	251	21	stem	stem	NOUN
gs-3446	251	22	cells	cell	NOUN
gs-3446	251	23	or	or	CCONJ
gs-3446	251	24	muscle	muscle	NOUN
gs-3446	251	25	satellite	satellite	NOUN
gs-3446	251	26	cells	cell	NOUN
gs-3446	251	27	,	,	PUNCT
gs-3446	251	28	exhibit	exhibit	VERB
gs-3446	251	29	more	more	ADV
gs-3446	251	30	stable	stable	ADJ
gs-3446	251	31	transcriptional	transcriptional	ADJ
gs-3446	251	32	states	state	NOUN
gs-3446	251	33	but	but	CCONJ
gs-3446	251	34	retain	retain	VERB
gs-3446	251	35	context	context	NOUN
gs-3446	251	36	-	-	PUNCT
gs-3446	251	37	dependent	dependent	ADJ
gs-3446	251	38	plasticity	plasticity	NOUN
gs-3446	251	39	.	.	PUNCT
gs-3446	252	1	their	their	PRON
gs-3446	252	2	transcriptional	transcriptional	ADJ
gs-3446	252	3	circuits	circuit	NOUN
gs-3446	252	4	,	,	PUNCT
gs-3446	252	5	controlled	control	VERB
gs-3446	252	6	by	by	ADP
gs-3446	252	7	factors	factor	NOUN
gs-3446	252	8	like	like	ADP
gs-3446	252	9	pax7	pax7	NOUN
gs-3446	252	10	in	in	ADP
gs-3446	252	11	muscle	muscle	NOUN
gs-3446	252	12	stem	stem	NOUN
gs-3446	252	13	cells	cell	NOUN
gs-3446	252	14	or	or	CCONJ
gs-3446	252	15	p63	p63	NOUN
gs-3446	252	16	in	in	ADP
gs-3446	252	17	epidermal	epidermal	ADJ
gs-3446	252	18	stem	stem	NOUN
gs-3446	252	19	cells	cell	NOUN
gs-3446	252	20	,	,	PUNCT
gs-3446	252	21	ensure	ensure	VERB
gs-3446	252	22	lineage	lineage	NOUN
gs-3446	252	23	fidelity	fidelity	NOUN
gs-3446	252	24	while	while	SCONJ
gs-3446	252	25	responding	respond	VERB
gs-3446	252	26	to	to	ADP
gs-3446	252	27	injury	injury	NOUN
gs-3446	252	28	or	or	CCONJ
gs-3446	252	29	physiological	physiological	ADJ
gs-3446	252	30	cues	cue	NOUN
gs-3446	252	31	(	(	PUNCT
gs-3446	252	32	aphkhazava	aphkhazava	NOUN
gs-3446	252	33	et	et	PROPN
gs-3446	252	34	al	al	PROPN
gs-3446	252	35	.	.	PROPN
gs-3446	252	36	2023	2023	NUM
gs-3446	252	37	)	)	PUNCT
gs-3446	252	38	.	.	PUNCT
gs-3446	253	1	understanding	understand	VERB
gs-3446	253	2	the	the	DET
gs-3446	253	3	mechanisms	mechanism	NOUN
gs-3446	253	4	underlying	underlie	VERB
gs-3446	253	5	stem	stem	NOUN
gs-3446	253	6	cell	cell	NOUN
gs-3446	253	7	heterogeneity	heterogeneity	NOUN
gs-3446	253	8	has	have	VERB
gs-3446	253	9	significant	significant	ADJ
gs-3446	253	10	implications	implication	NOUN
gs-3446	253	11	for	for	ADP
gs-3446	253	12	regenerative	regenerative	ADJ
gs-3446	253	13	medicine	medicine	NOUN
gs-3446	253	14	and	and	CCONJ
gs-3446	253	15	disease	disease	NOUN
gs-3446	253	16	modeling	modeling	NOUN
gs-3446	253	17	.	.	PUNCT
gs-3446	254	1	tailoring	tailor	VERB
gs-3446	254	2	differentiation	differentiation	NOUN
gs-3446	254	3	protocols	protocol	NOUN
gs-3446	254	4	based	base	VERB
gs-3446	254	5	on	on	ADP
gs-3446	254	6	transcriptional	transcriptional	ADJ
gs-3446	254	7	insights	insight	NOUN
gs-3446	254	8	can	can	AUX
gs-3446	254	9	improve	improve	VERB
gs-3446	254	10	the	the	DET
gs-3446	254	11	efficiency	efficiency	NOUN
gs-3446	254	12	and	and	CCONJ
gs-3446	254	13	reproducibility	reproducibility	NOUN
gs-3446	254	14	of	of	ADP
gs-3446	254	15	generating	generate	VERB
gs-3446	254	16	specific	specific	ADJ
gs-3446	254	17	cell	cell	NOUN
gs-3446	254	18	types	type	NOUN
gs-3446	254	19	for	for	ADP
gs-3446	254	20	therapy	therapy	NOUN
gs-3446	254	21	.	.	PUNCT
gs-3446	255	1	furthermore	furthermore	ADV
gs-3446	255	2	,	,	PUNCT
gs-3446	255	3	dissecting	dissect	VERB
gs-3446	255	4	stem	stem	NOUN
gs-3446	255	5	cell	cell	NOUN
gs-3446	255	6	transcriptional	transcriptional	NOUN
gs-3446	255	7	variability	variability	NOUN
gs-3446	255	8	can	can	AUX
gs-3446	255	9	help	help	VERB
gs-3446	255	10	refine	refine	VERB
gs-3446	255	11	strategies	strategy	NOUN
gs-3446	255	12	to	to	PART
gs-3446	255	13	mitigate	mitigate	VERB
gs-3446	255	14	unwanted	unwanted	ADJ
gs-3446	255	15	differentiation	differentiation	NOUN
gs-3446	255	16	biases	bias	NOUN
gs-3446	255	17	and	and	CCONJ
gs-3446	255	18	enhance	enhance	VERB
gs-3446	255	19	cell	cell	NOUN
gs-3446	255	20	-	-	PUNCT
gs-3446	255	21	based	base	VERB
gs-3446	255	22	interventions	intervention	NOUN
gs-3446	255	23	.	.	PUNCT
gs-3446	256	1	future	future	ADJ
gs-3446	256	2	research	research	NOUN
gs-3446	256	3	should	should	AUX
gs-3446	256	4	focus	focus	VERB
gs-3446	256	5	on	on	ADP
gs-3446	256	6	integrating	integrate	VERB
gs-3446	256	7	single	single	ADJ
gs-3446	256	8	-	-	PUNCT
gs-3446	256	9	cell	cell	NOUN
gs-3446	256	10	multiomics	multiomics	NOUN
gs-3446	256	11	approaches	approach	NOUN
gs-3446	256	12	to	to	PART
gs-3446	256	13	decode	decode	VERB
gs-3446	256	14	the	the	DET
gs-3446	256	15	full	full	ADJ
gs-3446	256	16	spectrum	spectrum	NOUN
gs-3446	256	17	of	of	ADP
gs-3446	256	18	transcriptional	transcriptional	ADJ
gs-3446	256	19	heterogeneity	heterogeneity	NOUN
gs-3446	256	20	and	and	CCONJ
gs-3446	256	21	its	its	PRON
gs-3446	256	22	functional	functional	ADJ
gs-3446	256	23	consequences	consequence	NOUN
gs-3446	256	24	.	.	PUNCT
gs-3446	257	1	additionally	additionally	ADV
gs-3446	257	2	,	,	PUNCT
gs-3446	257	3	leveraging	leverage	VERB
gs-3446	257	4	synthetic	synthetic	ADJ
gs-3446	257	5	biology	biology	NOUN
gs-3446	257	6	and	and	CCONJ
gs-3446	257	7	gene	gene	NOUN
gs-3446	257	8	-	-	PUNCT
gs-3446	257	9	editing	edit	VERB
gs-3446	257	10	technologies	technology	NOUN
gs-3446	257	11	could	could	AUX
gs-3446	257	12	allow	allow	VERB
gs-3446	257	13	precise	precise	ADJ
gs-3446	257	14	modulation	modulation	NOUN
gs-3446	257	15	of	of	ADP
gs-3446	257	16	transcriptional	transcriptional	ADJ
gs-3446	257	17	circuits	circuit	NOUN
gs-3446	257	18	,	,	PUNCT
gs-3446	257	19	paving	pave	VERB
gs-3446	257	20	the	the	DET
gs-3446	257	21	way	way	NOUN
gs-3446	257	22	for	for	ADP
gs-3446	257	23	improved	improved	ADJ
gs-3446	257	24	stem	stem	NOUN
gs-3446	257	25	cell	cell	NOUN
gs-3446	257	26	-	-	PUNCT
gs-3446	257	27	based	base	VERB
gs-3446	257	28	therapies	therapy	NOUN
gs-3446	257	29	.	.	PUNCT
gs-3446	258	1	by	by	ADP
gs-3446	258	2	advancing	advance	VERB
gs-3446	258	3	our	our	PRON
gs-3446	258	4	knowledge	knowledge	NOUN
gs-3446	258	5	of	of	ADP
gs-3446	258	6	stem	stem	NOUN
gs-3446	258	7	cell	cell	NOUN
gs-3446	258	8	heterogeneity	heterogeneity	NOUN
gs-3446	258	9	,	,	PUNCT
gs-3446	258	10	we	we	PRON
gs-3446	258	11	can	can	AUX
gs-3446	258	12	better	well	ADV
gs-3446	258	13	harness	harness	VERB
gs-3446	258	14	their	their	PRON
gs-3446	258	15	potential	potential	NOUN
gs-3446	258	16	for	for	ADP
gs-3446	258	17	regenerative	regenerative	ADJ
gs-3446	258	18	applications	application	NOUN
gs-3446	258	19	and	and	CCONJ
gs-3446	258	20	personalized	personalized	ADJ
gs-3446	258	21	medicine	medicine	NOUN
gs-3446	258	22	(	(	PUNCT
gs-3446	258	23	aphkhazava	aphkhazava	NOUN
gs-3446	258	24	et	et	PROPN
gs-3446	258	25	al	al	PROPN
gs-3446	258	26	.	.	PROPN
gs-3446	258	27	2024	2024	NUM
gs-3446	258	28	)	)	PUNCT
gs-3446	258	29	.	.	PUNCT
gs-3446	259	1	stem	stem	NOUN
gs-3446	259	2	cell	cell	NOUN
gs-3446	259	3	heterogeneity	heterogeneity	NOUN
gs-3446	259	4	and	and	CCONJ
gs-3446	259	5	transcriptional	transcriptional	ADJ
gs-3446	259	6	circuits	circuit	NOUN
gs-3446	259	7	stem	stem	VERB
gs-3446	259	8	cells	cell	NOUN
gs-3446	259	9	exhibit	exhibit	VERB
gs-3446	259	10	remarkable	remarkable	ADJ
gs-3446	259	11	functional	functional	ADJ
gs-3446	259	12	diversity	diversity	NOUN
gs-3446	259	13	,	,	PUNCT
gs-3446	259	14	ranging	range	VERB
gs-3446	259	15	from	from	ADP
gs-3446	259	16	pluripotent	pluripotent	ADJ
gs-3446	259	17	cells	cell	NOUN
gs-3446	259	18	capable	capable	ADJ
gs-3446	259	19	of	of	ADP
gs-3446	259	20	generating	generate	VERB
gs-3446	259	21	all	all	DET
gs-3446	259	22	embryonic	embryonic	ADJ
gs-3446	259	23	lineages	lineage	NOUN
gs-3446	259	24	to	to	ADP
gs-3446	259	25	multipotent	multipotent	NOUN
gs-3446	259	26	and	and	CCONJ
gs-3446	259	27	unipotent	unipotent	ADJ
gs-3446	259	28	cells	cell	NOUN
gs-3446	259	29	with	with	ADP
gs-3446	259	30	progressively	progressively	ADV
gs-3446	259	31	restricted	restrict	VERB
gs-3446	259	32	differentiation	differentiation	NOUN
gs-3446	259	33	potential	potential	NOUN
gs-3446	259	34	.	.	PUNCT
gs-3446	260	1	this	this	DET
gs-3446	260	2	heterogeneity	heterogeneity	NOUN
gs-3446	260	3	is	be	AUX
gs-3446	260	4	orchestrated	orchestrate	VERB
gs-3446	260	5	by	by	ADP
gs-3446	260	6	intricate	intricate	ADJ
gs-3446	260	7	transcriptional	transcriptional	ADJ
gs-3446	260	8	circuits	circuit	NOUN
gs-3446	260	9	that	that	PRON
gs-3446	260	10	regulate	regulate	VERB
gs-3446	260	11	cell	cell	NOUN
gs-3446	260	12	fate	fate	NOUN
gs-3446	260	13	decisions	decision	NOUN
gs-3446	260	14	,	,	PUNCT
gs-3446	260	15	self	self	NOUN
gs-3446	260	16	-	-	PUNCT
gs-3446	260	17	renewal	renewal	NOUN
gs-3446	260	18	,	,	PUNCT
gs-3446	260	19	and	and	CCONJ
gs-3446	260	20	lineage	lineage	NOUN
gs-3446	260	21	commitment	commitment	NOUN
gs-3446	260	22	.	.	PUNCT
gs-3446	261	1	●	●	PUNCT
gs-3446	261	2	pluripotency	pluripotency	NOUN
gs-3446	261	3	:	:	PUNCT
gs-3446	261	4	in	in	ADP
gs-3446	261	5	embryonic	embryonic	ADJ
gs-3446	261	6	stem	stem	NOUN
gs-3446	261	7	cells	cell	NOUN
gs-3446	261	8	(	(	PUNCT
gs-3446	261	9	escs	esc	NOUN
gs-3446	261	10	)	)	PUNCT
gs-3446	261	11	and	and	CCONJ
gs-3446	261	12	induced	induce	VERB
gs-3446	261	13	pluripotent	pluripotent	ADJ
gs-3446	261	14	stem	stem	NOUN
gs-3446	261	15	cells	cell	NOUN
gs-3446	261	16	(	(	PUNCT
gs-3446	261	17	ipscs	ipscs	NOUN
gs-3446	261	18	)	)	PUNCT
gs-3446	261	19	,	,	PUNCT
gs-3446	261	20	transcription	transcription	NOUN
gs-3446	261	21	factors	factor	NOUN
gs-3446	261	22	such	such	ADJ
gs-3446	261	23	as	as	ADP
gs-3446	261	24	oct4	oct4	NOUN
gs-3446	261	25	,	,	PUNCT
gs-3446	261	26	sox2	sox2	NOUN
gs-3446	261	27	,	,	PUNCT
gs-3446	261	28	and	and	CCONJ
gs-3446	261	29	nanog	nanog	PROPN
gs-3446	261	30	form	form	VERB
gs-3446	261	31	a	a	DET
gs-3446	261	32	core	core	ADJ
gs-3446	261	33	regulatory	regulatory	ADJ
gs-3446	261	34	network	network	NOUN
gs-3446	261	35	that	that	PRON
gs-3446	261	36	maintains	maintain	VERB
gs-3446	261	37	an	an	DET
gs-3446	261	38	undifferentiated	undifferentiated	ADJ
gs-3446	261	39	state	state	NOUN
gs-3446	261	40	while	while	SCONJ
gs-3446	261	41	suppressing	suppress	VERB
gs-3446	261	42	lineage	lineage	NOUN
gs-3446	261	43	-	-	PUNCT
gs-3446	261	44	specific	specific	ADJ
gs-3446	261	45	programs	program	NOUN
gs-3446	261	46	.	.	PUNCT
gs-3446	262	1	additional	additional	ADJ
gs-3446	262	2	factors	factor	NOUN
gs-3446	262	3	,	,	PUNCT
gs-3446	262	4	including	include	VERB
gs-3446	262	5	klf4	klf4	PROPN
gs-3446	262	6	,	,	PUNCT
gs-3446	262	7	esrrb	esrrb	NOUN
gs-3446	262	8	,	,	PUNCT
gs-3446	262	9	and	and	CCONJ
gs-3446	262	10	prdm14	prdm14	NOUN
gs-3446	262	11	,	,	PUNCT
gs-3446	262	12	fine	fine	ADJ
gs-3446	262	13	-	-	PUNCT
gs-3446	262	14	tune	tune	NOUN
gs-3446	262	15	chromatin	chromatin	NOUN
gs-3446	262	16	accessibility	accessibility	NOUN
gs-3446	262	17	and	and	CCONJ
gs-3446	262	18	stabilize	stabilize	VERB
gs-3446	262	19	the	the	DET
gs-3446	262	20	pluripotent	pluripotent	ADJ
gs-3446	262	21	state	state	NOUN
gs-3446	262	22	.	.	PUNCT
gs-3446	263	1	single	single	ADJ
gs-3446	263	2	-	-	PUNCT
gs-3446	263	3	cell	cell	NOUN
gs-3446	263	4	transcriptomics	transcriptomic	NOUN
gs-3446	263	5	has	have	AUX
gs-3446	263	6	revealed	reveal	VERB
gs-3446	263	7	that	that	SCONJ
gs-3446	263	8	even	even	ADV
gs-3446	263	9	within	within	ADP
gs-3446	263	10	pluripotent	pluripotent	ADJ
gs-3446	263	11	populations	population	NOUN
gs-3446	263	12	,	,	PUNCT
gs-3446	263	13	there	there	PRON
gs-3446	263	14	is	be	VERB
gs-3446	263	15	heterogeneity	heterogeneity	NOUN
gs-3446	263	16	driven	drive	VERB
gs-3446	263	17	by	by	ADP
gs-3446	263	18	fluctuating	fluctuate	VERB
gs-3446	263	19	expression	expression	NOUN
gs-3446	263	20	of	of	ADP
gs-3446	263	21	lineage	lineage	NOUN
gs-3446	263	22	-	-	PUNCT
gs-3446	263	23	priming	prime	VERB
gs-3446	263	24	genes	gene	NOUN
gs-3446	263	25	,	,	PUNCT
gs-3446	263	26	such	such	ADJ
gs-3446	263	27	as	as	ADP
gs-3446	263	28	gata6	gata6	NOUN
gs-3446	263	29	(	(	PUNCT
gs-3446	263	30	endoderm	endoderm	NOUN
gs-3446	263	31	)	)	PUNCT
gs-3446	263	32	and	and	CCONJ
gs-3446	263	33	t	t	PROPN
gs-3446	263	34	(	(	PUNCT
gs-3446	263	35	mesoderm	mesoderm	PROPN
gs-3446	263	36	)	)	PUNCT
gs-3446	263	37	,	,	PUNCT
gs-3446	263	38	highlighting	highlight	VERB
gs-3446	263	39	the	the	DET
gs-3446	263	40	dynamic	dynamic	ADJ
gs-3446	263	41	nature	nature	NOUN
gs-3446	263	42	of	of	ADP
gs-3446	263	43	early	early	ADJ
gs-3446	263	44	fate	fate	NOUN
gs-3446	263	45	commitment	commitment	NOUN
gs-3446	263	46	(	(	PUNCT
gs-3446	263	47	young	young	ADJ
gs-3446	263	48	et	et	PROPN
gs-3446	263	49	al	al	PROPN
gs-3446	263	50	.	.	PROPN
gs-3446	263	51	2011	2011	NUM
gs-3446	263	52	)	)	PUNCT
gs-3446	263	53	.	.	PUNCT
gs-3446	264	1	●	●	PUNCT
gs-3446	264	2	multipotency	multipotency	NOUN
gs-3446	264	3	:	:	PUNCT
gs-3446	264	4	multipotent	multipotent	NOUN
gs-3446	264	5	stem	stem	NOUN
gs-3446	264	6	cells	cell	NOUN
gs-3446	264	7	,	,	PUNCT
gs-3446	264	8	such	such	ADJ
gs-3446	264	9	as	as	ADP
gs-3446	264	10	hematopoietic	hematopoietic	ADJ
gs-3446	264	11	,	,	PUNCT
gs-3446	264	12	neural	neural	ADJ
gs-3446	264	13	,	,	PUNCT
gs-3446	264	14	and	and	CCONJ
gs-3446	264	15	mesenchymal	mesenchymal	ADJ
gs-3446	264	16	stem	stem	NOUN
gs-3446	264	17	cells	cell	NOUN
gs-3446	264	18	,	,	PUNCT
gs-3446	264	19	retain	retain	VERB
gs-3446	264	20	the	the	DET
gs-3446	264	21	ability	ability	NOUN
gs-3446	264	22	to	to	PART
gs-3446	264	23	differentiate	differentiate	VERB
gs-3446	264	24	into	into	ADP
gs-3446	264	25	multiple	multiple	ADJ
gs-3446	264	26	,	,	PUNCT
gs-3446	264	27	but	but	CCONJ
gs-3446	264	28	not	not	PART
gs-3446	264	29	all	all	PRON
gs-3446	264	30	,	,	PUNCT
gs-3446	264	31	cell	cell	NOUN
gs-3446	264	32	types	type	NOUN
gs-3446	264	33	.	.	PUNCT
gs-3446	265	1	their	their	PRON
gs-3446	265	2	transcriptional	transcriptional	ADJ
gs-3446	265	3	landscapes	landscape	NOUN
gs-3446	265	4	are	be	AUX
gs-3446	265	5	shaped	shape	VERB
gs-3446	265	6	by	by	ADP
gs-3446	265	7	lineage	lineage	NOUN
gs-3446	265	8	-	-	PUNCT
gs-3446	265	9	specific	specific	ADJ
gs-3446	265	10	master	master	NOUN
gs-3446	265	11	regulators	regulator	NOUN
gs-3446	265	12	,	,	PUNCT
gs-3446	265	13	including	include	VERB
gs-3446	265	14	gata2	gata2	NOUN
gs-3446	265	15	and	and	CCONJ
gs-3446	265	16	runx1	runx1	NOUN
gs-3446	265	17	in	in	ADP
gs-3446	265	18	hematopoiesis	hematopoiesis	NOUN
gs-3446	265	19	or	or	CCONJ
gs-3446	265	20	sox9	sox9	PROPN
gs-3446	265	21	and	and	CCONJ
gs-3446	265	22	pax6	pax6	PROPN
gs-3446	265	23	in	in	ADP
gs-3446	265	24	neural	neural	ADJ
gs-3446	265	25	progenitors	progenitor	NOUN
gs-3446	265	26	.	.	PUNCT
gs-3446	266	1	unlike	unlike	ADP
gs-3446	266	2	pluripotent	pluripotent	ADJ
gs-3446	266	3	cells	cell	NOUN
gs-3446	266	4	,	,	PUNCT
gs-3446	266	5	multipotent	multipotent	ADJ
gs-3446	266	6	georgian	georgian	ADJ
gs-3446	266	7	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3446	266	8	მეცნიერები	მეცნიერები	NOUN
gs-3446	266	9	ტ.	ტ.	VERB
gs-3446	266	10	7	7	NUM
gs-3446	266	11	n	n	PRON
gs-3446	266	12	1	1	NUM
gs-3446	266	13	,	,	PUNCT
gs-3446	266	14	2025	2025	NUM
gs-3446	266	15	287	287	NUM
gs-3446	266	16	stem	stem	NOUN
gs-3446	266	17	cells	cell	NOUN
gs-3446	266	18	exhibit	exhibit	VERB
gs-3446	266	19	more	more	ADV
gs-3446	266	20	stable	stable	ADJ
gs-3446	266	21	epigenetic	epigenetic	ADJ
gs-3446	266	22	marks	mark	NOUN
gs-3446	266	23	that	that	PRON
gs-3446	266	24	reinforce	reinforce	VERB
gs-3446	266	25	lineage	lineage	NOUN
gs-3446	266	26	priming	priming	NOUN
gs-3446	266	27	while	while	SCONJ
gs-3446	266	28	maintaining	maintain	VERB
gs-3446	266	29	plasticity	plasticity	NOUN
gs-3446	266	30	in	in	ADP
gs-3446	266	31	response	response	NOUN
gs-3446	266	32	to	to	ADP
gs-3446	266	33	environmental	environmental	ADJ
gs-3446	266	34	cues	cue	NOUN
gs-3446	266	35	(	(	PUNCT
gs-3446	266	36	zare	zare	PROPN
gs-3446	266	37	et	et	PROPN
gs-3446	266	38	al	al	PROPN
gs-3446	266	39	.	.	PROPN
gs-3446	266	40	2023	2023	NUM
gs-3446	266	41	)	)	PUNCT
gs-3446	266	42	.	.	PUNCT
gs-3446	267	1	●	●	PUNCT
gs-3446	267	2	unipotency	unipotency	NOUN
gs-3446	267	3	:	:	PUNCT
gs-3446	267	4	unipotent	unipotent	ADJ
gs-3446	267	5	stem	stem	NOUN
gs-3446	267	6	cells	cell	NOUN
gs-3446	267	7	,	,	PUNCT
gs-3446	267	8	such	such	ADJ
gs-3446	267	9	as	as	ADP
gs-3446	267	10	muscle	muscle	NOUN
gs-3446	267	11	satellite	satellite	NOUN
gs-3446	267	12	cells	cell	NOUN
gs-3446	267	13	or	or	CCONJ
gs-3446	267	14	epidermal	epidermal	ADJ
gs-3446	267	15	stem	stem	NOUN
gs-3446	267	16	cells	cell	NOUN
gs-3446	267	17	,	,	PUNCT
gs-3446	267	18	are	be	AUX
gs-3446	267	19	lineage	lineage	NOUN
gs-3446	267	20	-	-	PUNCT
gs-3446	267	21	restricted	restrict	VERB
gs-3446	267	22	but	but	CCONJ
gs-3446	267	23	retain	retain	VERB
gs-3446	267	24	self	self	NOUN
gs-3446	267	25	-	-	PUNCT
gs-3446	267	26	renewal	renewal	NOUN
gs-3446	267	27	potential	potential	NOUN
gs-3446	267	28	.	.	PUNCT
gs-3446	268	1	their	their	PRON
gs-3446	268	2	transcriptional	transcriptional	ADJ
gs-3446	268	3	networks	network	NOUN
gs-3446	268	4	are	be	AUX
gs-3446	268	5	dominated	dominate	VERB
gs-3446	268	6	by	by	ADP
gs-3446	268	7	key	key	ADJ
gs-3446	268	8	factors	factor	NOUN
gs-3446	268	9	like	like	ADP
gs-3446	268	10	myod1	myod1	NOUN
gs-3446	268	11	(	(	PUNCT
gs-3446	268	12	muscle	muscle	NOUN
gs-3446	268	13	)	)	PUNCT
gs-3446	268	14	and	and	CCONJ
gs-3446	268	15	tp63	tp63	PROPN
gs-3446	268	16	(	(	PUNCT
gs-3446	268	17	epidermis	epidermis	NOUN
gs-3446	268	18	)	)	PUNCT
gs-3446	268	19	,	,	PUNCT
gs-3446	268	20	which	which	PRON
gs-3446	268	21	tightly	tightly	ADV
gs-3446	268	22	regulate	regulate	VERB
gs-3446	268	23	tissue	tissue	NOUN
gs-3446	268	24	-	-	PUNCT
gs-3446	268	25	specific	specific	ADJ
gs-3446	268	26	programs	program	NOUN
gs-3446	268	27	.	.	PUNCT
gs-3446	269	1	the	the	DET
gs-3446	269	2	transition	transition	NOUN
gs-3446	269	3	from	from	ADP
gs-3446	269	4	multipotency	multipotency	NOUN
gs-3446	269	5	to	to	ADP
gs-3446	269	6	unipotency	unipotency	NOUN
gs-3446	269	7	involves	involve	VERB
gs-3446	269	8	the	the	DET
gs-3446	269	9	progressive	progressive	ADJ
gs-3446	269	10	silencing	silencing	NOUN
gs-3446	269	11	of	of	ADP
gs-3446	269	12	alternative	alternative	ADJ
gs-3446	269	13	lineage	lineage	NOUN
gs-3446	269	14	genes	gene	NOUN
gs-3446	269	15	,	,	PUNCT
gs-3446	269	16	often	often	ADV
gs-3446	269	17	through	through	ADP
gs-3446	269	18	chromatin	chromatin	NOUN
gs-3446	269	19	remodeling	remodeling	NOUN
gs-3446	269	20	complexes	complex	NOUN
gs-3446	269	21	like	like	ADP
gs-3446	269	22	polycomb	polycomb	ADJ
gs-3446	269	23	repressive	repressive	ADJ
gs-3446	269	24	complexes	complex	NOUN
gs-3446	269	25	(	(	PUNCT
gs-3446	269	26	prc1/2	prc1/2	PROPN
gs-3446	269	27	)	)	PUNCT
gs-3446	269	28	and	and	CCONJ
gs-3446	269	29	dna	dna	PROPN
gs-3446	269	30	methylation	methylation	NOUN
gs-3446	269	31	(	(	PUNCT
gs-3446	269	32	aphkhazava	aphkhazava	NOUN
gs-3446	269	33	et	et	PROPN
gs-3446	269	34	al	al	PROPN
gs-3446	269	35	.	.	PROPN
gs-3446	269	36	2023	2023	NUM
gs-3446	269	37	)	)	PUNCT
gs-3446	269	38	.	.	PUNCT
gs-3446	270	1	understanding	understand	VERB
gs-3446	270	2	the	the	DET
gs-3446	270	3	transcriptional	transcriptional	ADJ
gs-3446	270	4	circuits	circuit	NOUN
gs-3446	270	5	governing	govern	VERB
gs-3446	270	6	stem	stem	NOUN
gs-3446	270	7	cell	cell	NOUN
gs-3446	270	8	heterogeneity	heterogeneity	NOUN
gs-3446	270	9	is	be	AUX
gs-3446	270	10	crucial	crucial	ADJ
gs-3446	270	11	for	for	ADP
gs-3446	270	12	improving	improve	VERB
gs-3446	270	13	regenerative	regenerative	ADJ
gs-3446	270	14	medicine	medicine	NOUN
gs-3446	270	15	applications	application	NOUN
gs-3446	270	16	,	,	PUNCT
gs-3446	270	17	optimizing	optimize	VERB
gs-3446	270	18	stem	stem	NOUN
gs-3446	270	19	cell	cell	NOUN
gs-3446	270	20	differentiation	differentiation	NOUN
gs-3446	270	21	protocols	protocol	NOUN
gs-3446	270	22	,	,	PUNCT
gs-3446	270	23	and	and	CCONJ
gs-3446	270	24	uncovering	uncover	VERB
gs-3446	270	25	mechanisms	mechanism	NOUN
gs-3446	270	26	of	of	ADP
gs-3446	270	27	tissue	tissue	NOUN
gs-3446	270	28	homeostasis	homeostasis	NOUN
gs-3446	270	29	and	and	CCONJ
gs-3446	270	30	disease	disease	NOUN
gs-3446	270	31	progression	progression	NOUN
gs-3446	270	32	.	.	PUNCT
gs-3446	271	1	recent	recent	ADJ
gs-3446	271	2	advances	advance	NOUN
gs-3446	271	3	in	in	ADP
gs-3446	271	4	single	single	ADJ
gs-3446	271	5	-	-	PUNCT
gs-3446	271	6	cell	cell	NOUN
gs-3446	271	7	sequencing	sequencing	NOUN
gs-3446	271	8	and	and	CCONJ
gs-3446	271	9	chromatin	chromatin	NOUN
gs-3446	271	10	profiling	profiling	NOUN
gs-3446	271	11	have	have	AUX
gs-3446	271	12	provided	provide	VERB
gs-3446	271	13	unprecedented	unprecedented	ADJ
gs-3446	271	14	insights	insight	NOUN
gs-3446	271	15	into	into	ADP
gs-3446	271	16	how	how	SCONJ
gs-3446	271	17	transcriptional	transcriptional	ADJ
gs-3446	271	18	fluctuations	fluctuation	NOUN
gs-3446	271	19	,	,	PUNCT
gs-3446	271	20	epigenetic	epigenetic	ADJ
gs-3446	271	21	modifications	modification	NOUN
gs-3446	271	22	,	,	PUNCT
gs-3446	271	23	and	and	CCONJ
gs-3446	271	24	extrinsic	extrinsic	ADJ
gs-3446	271	25	signals	signal	NOUN
gs-3446	271	26	contribute	contribute	VERB
gs-3446	271	27	to	to	ADP
gs-3446	271	28	stem	stem	NOUN
gs-3446	271	29	cell	cell	NOUN
gs-3446	271	30	diversity	diversity	NOUN
gs-3446	271	31	across	across	ADP
gs-3446	271	32	different	different	ADJ
gs-3446	271	33	potency	potency	NOUN
gs-3446	271	34	states	state	NOUN
gs-3446	271	35	(	(	PUNCT
gs-3446	271	36	zare	zare	PROPN
gs-3446	271	37	et	et	PROPN
gs-3446	271	38	al	al	PROPN
gs-3446	271	39	.	.	PROPN
gs-3446	271	40	2023	2023	NUM
gs-3446	271	41	)	)	PUNCT
gs-3446	271	42	.	.	PUNCT
gs-3446	272	1	discussion	discussion	NOUN
gs-3446	272	2	:	:	PUNCT
gs-3446	272	3	transcriptional	transcriptional	ADJ
gs-3446	272	4	circuits	circuit	NOUN
gs-3446	272	5	in	in	ADP
gs-3446	272	6	stem	stem	NOUN
gs-3446	272	7	cell	cell	NOUN
gs-3446	272	8	heterogeneity	heterogeneity	NOUN
gs-3446	272	9	the	the	DET
gs-3446	272	10	complexity	complexity	NOUN
gs-3446	272	11	of	of	ADP
gs-3446	272	12	stem	stem	NOUN
gs-3446	272	13	cell	cell	NOUN
gs-3446	272	14	heterogeneity	heterogeneity	NOUN
gs-3446	272	15	arises	arise	VERB
gs-3446	272	16	from	from	ADP
gs-3446	272	17	dynamic	dynamic	ADJ
gs-3446	272	18	transcriptional	transcriptional	ADJ
gs-3446	272	19	circuits	circuit	NOUN
gs-3446	272	20	that	that	PRON
gs-3446	272	21	govern	govern	VERB
gs-3446	272	22	their	their	PRON
gs-3446	272	23	self	self	NOUN
gs-3446	272	24	-	-	PUNCT
gs-3446	272	25	renewal	renewal	NOUN
gs-3446	272	26	,	,	PUNCT
gs-3446	272	27	plasticity	plasticity	NOUN
gs-3446	272	28	,	,	PUNCT
gs-3446	272	29	and	and	CCONJ
gs-3446	272	30	lineage	lineage	NOUN
gs-3446	272	31	commitment	commitment	NOUN
gs-3446	272	32	.	.	PUNCT
gs-3446	273	1	understanding	understand	VERB
gs-3446	273	2	the	the	DET
gs-3446	273	3	interplay	interplay	NOUN
gs-3446	273	4	between	between	ADP
gs-3446	273	5	these	these	DET
gs-3446	273	6	regulatory	regulatory	ADJ
gs-3446	273	7	networks	network	NOUN
gs-3446	273	8	across	across	ADP
gs-3446	273	9	pluripotent	pluripotent	NOUN
gs-3446	273	10	,	,	PUNCT
gs-3446	273	11	multipotent	multipotent	NOUN
gs-3446	273	12	,	,	PUNCT
gs-3446	273	13	and	and	CCONJ
gs-3446	273	14	unipotent	unipotent	ADJ
gs-3446	273	15	states	state	NOUN
gs-3446	273	16	provides	provide	VERB
gs-3446	273	17	key	key	ADJ
gs-3446	273	18	insights	insight	NOUN
gs-3446	273	19	into	into	ADP
gs-3446	273	20	developmental	developmental	ADJ
gs-3446	273	21	biology	biology	NOUN
gs-3446	273	22	and	and	CCONJ
gs-3446	273	23	regenerative	regenerative	ADJ
gs-3446	273	24	medicine	medicine	NOUN
gs-3446	273	25	.	.	PUNCT
gs-3446	274	1	pluripotency	pluripotency	NOUN
gs-3446	274	2	:	:	PUNCT
gs-3446	274	3	a	a	DET
gs-3446	274	4	balancing	balance	VERB
gs-3446	274	5	act	act	NOUN
gs-3446	274	6	of	of	ADP
gs-3446	274	7	self	self	NOUN
gs-3446	274	8	-	-	PUNCT
gs-3446	274	9	renewal	renewal	NOUN
gs-3446	274	10	and	and	CCONJ
gs-3446	274	11	lineage	lineage	NOUN
gs-3446	274	12	priming	prime	VERB
gs-3446	274	13	pluripotent	pluripotent	ADJ
gs-3446	274	14	stem	stem	NOUN
gs-3446	274	15	cells	cell	NOUN
gs-3446	274	16	(	(	PUNCT
gs-3446	274	17	pscs	psc	NOUN
gs-3446	274	18	)	)	PUNCT
gs-3446	274	19	exist	exist	VERB
gs-3446	274	20	in	in	ADP
gs-3446	274	21	a	a	DET
gs-3446	274	22	dynamic	dynamic	ADJ
gs-3446	274	23	equilibrium	equilibrium	NOUN
gs-3446	274	24	where	where	SCONJ
gs-3446	274	25	fluctuations	fluctuation	NOUN
gs-3446	274	26	in	in	ADP
gs-3446	274	27	transcription	transcription	NOUN
gs-3446	274	28	factor	factor	NOUN
gs-3446	274	29	expression	expression	NOUN
gs-3446	274	30	contribute	contribute	VERB
gs-3446	274	31	to	to	ADP
gs-3446	274	32	heterogeneity	heterogeneity	NOUN
gs-3446	274	33	within	within	ADP
gs-3446	274	34	the	the	DET
gs-3446	274	35	population	population	NOUN
gs-3446	274	36	.	.	PUNCT
gs-3446	275	1	the	the	DET
gs-3446	275	2	core	core	ADJ
gs-3446	275	3	transcriptional	transcriptional	ADJ
gs-3446	275	4	circuit	circuit	NOUN
gs-3446	275	5	—	—	PUNCT
gs-3446	275	6	oct4	oct4	NOUN
gs-3446	275	7	,	,	PUNCT
gs-3446	275	8	sox2	sox2	NOUN
gs-3446	275	9	,	,	PUNCT
gs-3446	275	10	and	and	CCONJ
gs-3446	275	11	nanog	nanog	PROPN
gs-3446	275	12	(	(	PUNCT
gs-3446	275	13	osn)—maintains	osn)—maintain	NOUN
gs-3446	275	14	self	self	NOUN
gs-3446	275	15	-	-	PUNCT
gs-3446	275	16	renewal	renewal	NOUN
gs-3446	275	17	while	while	SCONJ
gs-3446	275	18	repressing	repress	VERB
gs-3446	275	19	differentiation	differentiation	NOUN
gs-3446	275	20	signals	signal	NOUN
gs-3446	275	21	.	.	PUNCT
gs-3446	276	1	however	however	ADV
gs-3446	276	2	,	,	PUNCT
gs-3446	276	3	subsets	subset	NOUN
gs-3446	276	4	of	of	ADP
gs-3446	276	5	cells	cell	NOUN
gs-3446	276	6	within	within	ADP
gs-3446	276	7	pluripotent	pluripotent	ADJ
gs-3446	276	8	cultures	culture	NOUN
gs-3446	276	9	exhibit	exhibit	VERB
gs-3446	276	10	differential	differential	ADJ
gs-3446	276	11	expression	expression	NOUN
gs-3446	276	12	of	of	ADP
gs-3446	276	13	lineage	lineage	NOUN
gs-3446	276	14	-	-	PUNCT
gs-3446	276	15	associated	associate	VERB
gs-3446	276	16	factors	factor	NOUN
gs-3446	276	17	,	,	PUNCT
gs-3446	276	18	such	such	ADJ
gs-3446	276	19	as	as	ADP
gs-3446	276	20	gata6	gata6	NOUN
gs-3446	276	21	(	(	PUNCT
gs-3446	276	22	endoderm	endoderm	NOUN
gs-3446	276	23	)	)	PUNCT
gs-3446	276	24	,	,	PUNCT
gs-3446	276	25	t	t	PROPN
gs-3446	276	26	/	/	SYM
gs-3446	276	27	brachyury	brachyury	NOUN
gs-3446	276	28	(	(	PUNCT
gs-3446	276	29	mesoderm	mesoderm	NOUN
gs-3446	276	30	)	)	PUNCT
gs-3446	276	31	,	,	PUNCT
gs-3446	276	32	and	and	CCONJ
gs-3446	276	33	sox1	sox1	NOUN
gs-3446	276	34	(	(	PUNCT
gs-3446	276	35	ectoderm	ectoderm	NOUN
gs-3446	276	36	)	)	PUNCT
gs-3446	276	37	,	,	PUNCT
gs-3446	276	38	indicating	indicate	VERB
gs-3446	276	39	priming	prime	VERB
gs-3446	276	40	toward	toward	ADP
gs-3446	276	41	specific	specific	ADJ
gs-3446	276	42	fates	fate	NOUN
gs-3446	276	43	.	.	PUNCT
gs-3446	277	1	this	this	DET
gs-3446	277	2	heterogeneity	heterogeneity	NOUN
gs-3446	277	3	is	be	AUX
gs-3446	277	4	not	not	PART
gs-3446	277	5	merely	merely	ADV
gs-3446	277	6	noise	noise	NOUN
gs-3446	277	7	but	but	CCONJ
gs-3446	277	8	a	a	DET
gs-3446	277	9	functional	functional	ADJ
gs-3446	277	10	feature	feature	NOUN
gs-3446	277	11	that	that	PRON
gs-3446	277	12	enhances	enhance	VERB
gs-3446	277	13	the	the	DET
gs-3446	277	14	adaptability	adaptability	NOUN
gs-3446	277	15	of	of	ADP
gs-3446	277	16	pluripotent	pluripotent	ADJ
gs-3446	277	17	cells	cell	NOUN
gs-3446	277	18	.	.	PUNCT
gs-3446	278	1	for	for	ADP
gs-3446	278	2	instance	instance	NOUN
gs-3446	278	3	,	,	PUNCT
gs-3446	278	4	studies	study	NOUN
gs-3446	278	5	using	use	VERB
gs-3446	278	6	single	single	ADJ
gs-3446	278	7	-	-	PUNCT
gs-3446	278	8	cell	cell	NOUN
gs-3446	278	9	rna	rna	NOUN
gs-3446	278	10	sequencing	sequence	VERB
gs-3446	278	11	(	(	PUNCT
gs-3446	278	12	scrna	scrna	NOUN
gs-3446	278	13	-	-	PUNCT
gs-3446	278	14	seq	seq	NOUN
gs-3446	278	15	)	)	PUNCT
gs-3446	278	16	have	have	AUX
gs-3446	278	17	revealed	reveal	VERB
gs-3446	278	18	transient	transient	ADJ
gs-3446	278	19	subpopulations	subpopulation	NOUN
gs-3446	278	20	with	with	ADP
gs-3446	278	21	biased	biased	ADJ
gs-3446	278	22	differentiation	differentiation	NOUN
gs-3446	278	23	potential	potential	NOUN
gs-3446	278	24	.	.	PUNCT
gs-3446	279	1	such	such	ADJ
gs-3446	279	2	variability	variability	NOUN
gs-3446	279	3	may	may	AUX
gs-3446	279	4	be	be	AUX
gs-3446	279	5	regulated	regulate	VERB
gs-3446	279	6	by	by	ADP
gs-3446	279	7	extrinsic	extrinsic	ADJ
gs-3446	279	8	signals	signal	NOUN
gs-3446	279	9	(	(	PUNCT
gs-3446	279	10	e.g.	e.g.	ADV
gs-3446	279	11	,	,	PUNCT
gs-3446	279	12	wnt	wnt	PROPN
gs-3446	279	13	,	,	PUNCT
gs-3446	279	14	bmp	bmp	PROPN
gs-3446	279	15	,	,	PUNCT
gs-3446	279	16	fgf	fgf	PROPN
gs-3446	279	17	,	,	PUNCT
gs-3446	279	18	and	and	CCONJ
gs-3446	279	19	tgf	tgf	PROPN
gs-3446	279	20	-	-	PUNCT
gs-3446	279	21	β	β	NOUN
gs-3446	279	22	pathways	pathway	NOUN
gs-3446	279	23	)	)	PUNCT
gs-3446	279	24	as	as	ADV
gs-3446	279	25	well	well	ADV
gs-3446	279	26	as	as	ADP
gs-3446	279	27	epigenetic	epigenetic	ADJ
gs-3446	279	28	modifications	modification	NOUN
gs-3446	279	29	(	(	PUNCT
gs-3446	279	30	e.g.	e.g.	ADV
gs-3446	279	31	,	,	PUNCT
gs-3446	279	32	histone	histone	NOUN
gs-3446	279	33	modifications	modification	NOUN
gs-3446	279	34	,	,	PUNCT
gs-3446	279	35	dna	dna	PROPN
gs-3446	279	36	methylation	methylation	NOUN
gs-3446	279	37	,	,	PUNCT
gs-3446	279	38	and	and	CCONJ
gs-3446	279	39	chromatin	chromatin	NOUN
gs-3446	279	40	accessibility	accessibility	NOUN
gs-3446	279	41	changes	change	NOUN
gs-3446	279	42	)	)	PUNCT
gs-3446	279	43	(	(	PUNCT
gs-3446	279	44	zare	zare	PROPN
gs-3446	279	45	et	et	PROPN
gs-3446	279	46	al	al	PROPN
gs-3446	279	47	.	.	PROPN
gs-3446	279	48	2023	2023	NUM
gs-3446	279	49	)	)	PUNCT
gs-3446	279	50	.	.	PUNCT
gs-3446	280	1	georgian	georgian	ADJ
gs-3446	280	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	280	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	280	4	ტ.	ტ.	VERB
gs-3446	280	5	7	7	NUM
gs-3446	280	6	n	n	PRON
gs-3446	280	7	1	1	NUM
gs-3446	280	8	,	,	PUNCT
gs-3446	280	9	2025	2025	NUM
gs-3446	280	10	288	288	NUM
gs-3446	280	11	multipotency	multipotency	NOUN
gs-3446	280	12	:	:	PUNCT
gs-3446	280	13	transcriptional	transcriptional	ADJ
gs-3446	280	14	networks	network	NOUN
gs-3446	280	15	restricting	restrict	VERB
gs-3446	280	16	lineage	lineage	NOUN
gs-3446	280	17	potential	potential	ADJ
gs-3446	280	18	multipotent	multipotent	NOUN
gs-3446	280	19	stem	stem	NOUN
gs-3446	280	20	cells	cell	NOUN
gs-3446	280	21	,	,	PUNCT
gs-3446	280	22	such	such	ADJ
gs-3446	280	23	as	as	ADP
gs-3446	280	24	hematopoietic	hematopoietic	ADJ
gs-3446	280	25	,	,	PUNCT
gs-3446	280	26	neural	neural	ADJ
gs-3446	280	27	,	,	PUNCT
gs-3446	280	28	and	and	CCONJ
gs-3446	280	29	mesenchymal	mesenchymal	ADJ
gs-3446	280	30	stem	stem	NOUN
gs-3446	280	31	cells	cell	NOUN
gs-3446	280	32	,	,	PUNCT
gs-3446	280	33	exhibit	exhibit	VERB
gs-3446	280	34	a	a	DET
gs-3446	280	35	more	more	ADV
gs-3446	280	36	constrained	constrained	ADJ
gs-3446	280	37	transcriptional	transcriptional	ADJ
gs-3446	280	38	landscape	landscape	NOUN
gs-3446	280	39	compared	compare	VERB
gs-3446	280	40	to	to	ADP
gs-3446	280	41	pscs	psc	NOUN
gs-3446	280	42	.	.	PUNCT
gs-3446	281	1	here	here	ADV
gs-3446	281	2	,	,	PUNCT
gs-3446	281	3	lineage	lineage	NOUN
gs-3446	281	4	-	-	PUNCT
gs-3446	281	5	specific	specific	ADJ
gs-3446	281	6	master	master	NOUN
gs-3446	281	7	regulators	regulator	NOUN
gs-3446	281	8	,	,	PUNCT
gs-3446	281	9	such	such	ADJ
gs-3446	281	10	as	as	ADP
gs-3446	281	11	runx1	runx1	NOUN
gs-3446	281	12	(	(	PUNCT
gs-3446	281	13	hematopoietic	hematopoietic	ADJ
gs-3446	281	14	)	)	PUNCT
gs-3446	281	15	,	,	PUNCT
gs-3446	281	16	sox9	sox9	PROPN
gs-3446	281	17	(	(	PUNCT
gs-3446	281	18	neural	neural	ADJ
gs-3446	281	19	crest	crest	NOUN
gs-3446	281	20	)	)	PUNCT
gs-3446	281	21	,	,	PUNCT
gs-3446	281	22	and	and	CCONJ
gs-3446	281	23	pax7	pax7	PROPN
gs-3446	281	24	(	(	PUNCT
gs-3446	281	25	muscle	muscle	NOUN
gs-3446	281	26	progenitors	progenitor	NOUN
gs-3446	281	27	)	)	PUNCT
gs-3446	281	28	,	,	PUNCT
gs-3446	281	29	play	play	VERB
gs-3446	281	30	critical	critical	ADJ
gs-3446	281	31	roles	role	NOUN
gs-3446	281	32	in	in	ADP
gs-3446	281	33	determining	determine	VERB
gs-3446	281	34	fate	fate	ADJ
gs-3446	281	35	choices	choice	NOUN
gs-3446	281	36	.	.	PUNCT
gs-3446	282	1	however	however	ADV
gs-3446	282	2	,	,	PUNCT
gs-3446	282	3	these	these	DET
gs-3446	282	4	cells	cell	NOUN
gs-3446	282	5	still	still	ADV
gs-3446	282	6	retain	retain	VERB
gs-3446	282	7	a	a	DET
gs-3446	282	8	degree	degree	NOUN
gs-3446	282	9	of	of	ADP
gs-3446	282	10	plasticity	plasticity	NOUN
gs-3446	282	11	,	,	PUNCT
gs-3446	282	12	allowing	allow	VERB
gs-3446	282	13	them	they	PRON
gs-3446	282	14	to	to	PART
gs-3446	282	15	respond	respond	VERB
gs-3446	282	16	to	to	ADP
gs-3446	282	17	external	external	ADJ
gs-3446	282	18	cues	cue	NOUN
gs-3446	282	19	(	(	PUNCT
gs-3446	282	20	aphkhazava	aphkhazava	NOUN
gs-3446	282	21	et	et	PROPN
gs-3446	282	22	al	al	PROPN
gs-3446	282	23	.	.	PROPN
gs-3446	282	24	2023	2023	NUM
gs-3446	282	25	)	)	PUNCT
gs-3446	282	26	.	.	PUNCT
gs-3446	283	1	in	in	ADP
gs-3446	283	2	the	the	DET
gs-3446	283	3	hematopoietic	hematopoietic	ADJ
gs-3446	283	4	system	system	NOUN
gs-3446	283	5	,	,	PUNCT
gs-3446	283	6	for	for	ADP
gs-3446	283	7	example	example	NOUN
gs-3446	283	8	,	,	PUNCT
gs-3446	283	9	a	a	DET
gs-3446	283	10	hierarchical	hierarchical	ADJ
gs-3446	283	11	transcriptional	transcriptional	NOUN
gs-3446	283	12	network	network	NOUN
gs-3446	283	13	controls	control	VERB
gs-3446	283	14	differentiation	differentiation	NOUN
gs-3446	283	15	.	.	PUNCT
gs-3446	284	1	gata2	gata2	NOUN
gs-3446	284	2	and	and	CCONJ
gs-3446	284	3	runx1	runx1	NOUN
gs-3446	284	4	initiate	initiate	VERB
gs-3446	284	5	hematopoietic	hematopoietic	ADJ
gs-3446	284	6	stem	stem	NOUN
gs-3446	284	7	cell	cell	NOUN
gs-3446	284	8	(	(	PUNCT
gs-3446	284	9	hsc	hsc	NOUN
gs-3446	284	10	)	)	PUNCT
gs-3446	284	11	specification	specification	NOUN
gs-3446	284	12	,	,	PUNCT
gs-3446	284	13	while	while	SCONJ
gs-3446	284	14	laterstage	laterstage	NOUN
gs-3446	284	15	decisions	decision	NOUN
gs-3446	284	16	are	be	AUX
gs-3446	284	17	controlled	control	VERB
gs-3446	284	18	by	by	ADP
gs-3446	284	19	factors	factor	NOUN
gs-3446	284	20	like	like	ADP
gs-3446	284	21	pu.1	pu.1	PROPN
gs-3446	284	22	(	(	PUNCT
gs-3446	284	23	myeloid	myeloid	ADJ
gs-3446	284	24	lineage	lineage	NOUN
gs-3446	284	25	)	)	PUNCT
gs-3446	284	26	and	and	CCONJ
gs-3446	284	27	gata1	gata1	NOUN
gs-3446	284	28	(	(	PUNCT
gs-3446	284	29	erythroid	erythroid	ADJ
gs-3446	284	30	lineage	lineage	NOUN
gs-3446	284	31	)	)	PUNCT
gs-3446	284	32	.	.	PUNCT
gs-3446	285	1	similarly	similarly	ADV
gs-3446	285	2	,	,	PUNCT
gs-3446	285	3	neural	neural	ADJ
gs-3446	285	4	progenitor	progenitor	NOUN
gs-3446	285	5	cells	cell	NOUN
gs-3446	285	6	balance	balance	VERB
gs-3446	285	7	neurogenic	neurogenic	ADJ
gs-3446	285	8	and	and	CCONJ
gs-3446	285	9	gliogenic	gliogenic	ADJ
gs-3446	285	10	programs	program	NOUN
gs-3446	285	11	through	through	ADP
gs-3446	285	12	the	the	DET
gs-3446	285	13	coordinated	coordinated	ADJ
gs-3446	285	14	action	action	NOUN
gs-3446	285	15	of	of	ADP
gs-3446	285	16	sox2	sox2	NOUN
gs-3446	285	17	,	,	PUNCT
gs-3446	285	18	ascl1	ascl1	ADJ
gs-3446	285	19	,	,	PUNCT
gs-3446	285	20	and	and	CCONJ
gs-3446	285	21	hes1	hes1	PROPN
gs-3446	285	22	,	,	PUNCT
gs-3446	285	23	where	where	SCONJ
gs-3446	285	24	oscillatory	oscillatory	ADJ
gs-3446	285	25	expression	expression	NOUN
gs-3446	285	26	patterns	pattern	NOUN
gs-3446	285	27	influence	influence	VERB
gs-3446	285	28	fate	fate	NOUN
gs-3446	285	29	decisions	decision	NOUN
gs-3446	285	30	(	(	PUNCT
gs-3446	285	31	orkin	orkin	PROPN
gs-3446	285	32	et	et	PROPN
gs-3446	285	33	al	al	PROPN
gs-3446	285	34	.	.	PROPN
gs-3446	285	35	2008	2008	NUM
gs-3446	285	36	)	)	PUNCT
gs-3446	285	37	.	.	PUNCT
gs-3446	286	1	unipotency	unipotency	NOUN
gs-3446	286	2	:	:	PUNCT
gs-3446	286	3	transcriptional	transcriptional	ADJ
gs-3446	286	4	commitment	commitment	NOUN
gs-3446	286	5	to	to	ADP
gs-3446	286	6	a	a	DET
gs-3446	286	7	single	single	ADJ
gs-3446	286	8	lineage	lineage	NOUN
gs-3446	286	9	as	as	ADP
gs-3446	286	10	stem	stem	NOUN
gs-3446	286	11	cells	cell	NOUN
gs-3446	286	12	transition	transition	NOUN
gs-3446	286	13	to	to	ADP
gs-3446	286	14	unipotency	unipotency	NOUN
gs-3446	286	15	,	,	PUNCT
gs-3446	286	16	transcriptional	transcriptional	ADJ
gs-3446	286	17	circuits	circuit	NOUN
gs-3446	286	18	become	become	VERB
gs-3446	286	19	more	more	ADV
gs-3446	286	20	restricted	restricted	ADJ
gs-3446	286	21	,	,	PUNCT
gs-3446	286	22	locking	locking	NOUN
gs-3446	286	23	cells	cell	NOUN
gs-3446	286	24	into	into	ADP
gs-3446	286	25	a	a	DET
gs-3446	286	26	single	single	ADJ
gs-3446	286	27	lineage	lineage	NOUN
gs-3446	286	28	.	.	PUNCT
gs-3446	287	1	this	this	PRON
gs-3446	287	2	is	be	AUX
gs-3446	287	3	evident	evident	ADJ
gs-3446	287	4	in	in	ADP
gs-3446	287	5	tissue	tissue	NOUN
gs-3446	287	6	-	-	PUNCT
gs-3446	287	7	specific	specific	ADJ
gs-3446	287	8	stem	stem	NOUN
gs-3446	287	9	cells	cell	NOUN
gs-3446	287	10	such	such	ADJ
gs-3446	287	11	as	as	ADP
gs-3446	287	12	muscle	muscle	NOUN
gs-3446	287	13	satellite	satellite	NOUN
gs-3446	287	14	cells	cell	NOUN
gs-3446	287	15	(	(	PUNCT
gs-3446	287	16	myod1	myod1	NOUN
gs-3446	287	17	,	,	PUNCT
gs-3446	287	18	pax7	pax7	PROPN
gs-3446	287	19	)	)	PUNCT
gs-3446	287	20	and	and	CCONJ
gs-3446	287	21	epidermal	epidermal	ADJ
gs-3446	287	22	basal	basal	ADJ
gs-3446	287	23	cells	cell	NOUN
gs-3446	287	24	(	(	PUNCT
gs-3446	287	25	tp63	tp63	PROPN
gs-3446	287	26	,	,	PUNCT
gs-3446	287	27	klf4	klf4	PROPN
gs-3446	287	28	)	)	PUNCT
gs-3446	287	29	.	.	PUNCT
gs-3446	288	1	the	the	DET
gs-3446	288	2	progressive	progressive	ADJ
gs-3446	288	3	loss	loss	NOUN
gs-3446	288	4	of	of	ADP
gs-3446	288	5	alternative	alternative	ADJ
gs-3446	288	6	lineage	lineage	NOUN
gs-3446	288	7	potential	potential	NOUN
gs-3446	288	8	is	be	AUX
gs-3446	288	9	reinforced	reinforce	VERB
gs-3446	288	10	by	by	ADP
gs-3446	288	11	chromatin	chromatin	NOUN
gs-3446	288	12	modifications	modification	NOUN
gs-3446	288	13	,	,	PUNCT
gs-3446	288	14	including	include	VERB
gs-3446	288	15	polycomb	polycomb	ADJ
gs-3446	288	16	repressive	repressive	ADJ
gs-3446	288	17	complexes	complex	NOUN
gs-3446	288	18	(	(	PUNCT
gs-3446	288	19	prc1/2	prc1/2	PROPN
gs-3446	288	20	)	)	PUNCT
gs-3446	288	21	,	,	PUNCT
gs-3446	288	22	which	which	PRON
gs-3446	288	23	silence	silence	VERB
gs-3446	288	24	non	non	ADJ
gs-3446	288	25	-	-	ADJ
gs-3446	288	26	lineage	lineage	ADJ
gs-3446	288	27	genes	gene	NOUN
gs-3446	288	28	to	to	PART
gs-3446	288	29	maintain	maintain	VERB
gs-3446	288	30	unipotent	unipotent	ADJ
gs-3446	288	31	identity	identity	NOUN
gs-3446	288	32	(	(	PUNCT
gs-3446	288	33	aphkhazava	aphkhazava	NOUN
gs-3446	288	34	et	et	PROPN
gs-3446	288	35	al	al	PROPN
gs-3446	288	36	.	.	PROPN
gs-3446	288	37	2023	2023	NUM
gs-3446	288	38	)	)	PUNCT
gs-3446	288	39	.	.	PUNCT
gs-3446	289	1	while	while	SCONJ
gs-3446	289	2	unipotent	unipotent	ADJ
gs-3446	289	3	stem	stem	NOUN
gs-3446	289	4	cells	cell	NOUN
gs-3446	289	5	are	be	AUX
gs-3446	289	6	highly	highly	ADV
gs-3446	289	7	specialized	specialized	ADJ
gs-3446	289	8	,	,	PUNCT
gs-3446	289	9	recent	recent	ADJ
gs-3446	289	10	studies	study	NOUN
gs-3446	289	11	challenge	challenge	VERB
gs-3446	289	12	the	the	DET
gs-3446	289	13	notion	notion	NOUN
gs-3446	289	14	of	of	ADP
gs-3446	289	15	absolute	absolute	ADJ
gs-3446	289	16	unipotency	unipotency	NOUN
gs-3446	289	17	.	.	PUNCT
gs-3446	290	1	under	under	ADP
gs-3446	290	2	certain	certain	ADJ
gs-3446	290	3	conditions	condition	NOUN
gs-3446	290	4	,	,	PUNCT
gs-3446	290	5	such	such	ADJ
gs-3446	290	6	as	as	ADP
gs-3446	290	7	injury	injury	NOUN
gs-3446	290	8	or	or	CCONJ
gs-3446	290	9	reprogramming	reprogramme	VERB
gs-3446	290	10	signals	signal	NOUN
gs-3446	290	11	,	,	PUNCT
gs-3446	290	12	some	some	DET
gs-3446	290	13	unipotent	unipotent	ADJ
gs-3446	290	14	cells	cell	NOUN
gs-3446	290	15	can	can	AUX
gs-3446	290	16	exhibit	exhibit	VERB
gs-3446	290	17	plasticity	plasticity	NOUN
gs-3446	290	18	,	,	PUNCT
gs-3446	290	19	suggesting	suggest	VERB
gs-3446	290	20	that	that	SCONJ
gs-3446	290	21	their	their	PRON
gs-3446	290	22	transcriptional	transcriptional	ADJ
gs-3446	290	23	circuits	circuit	NOUN
gs-3446	290	24	,	,	PUNCT
gs-3446	290	25	while	while	SCONJ
gs-3446	290	26	restrictive	restrictive	ADJ
gs-3446	290	27	,	,	PUNCT
gs-3446	290	28	retain	retain	VERB
gs-3446	290	29	latent	latent	ADJ
gs-3446	290	30	potential	potential	NOUN
gs-3446	290	31	for	for	ADP
gs-3446	290	32	fate	fate	NOUN
gs-3446	290	33	conversion	conversion	NOUN
gs-3446	290	34	.	.	PUNCT
gs-3446	291	1	implications	implication	NOUN
gs-3446	291	2	for	for	ADP
gs-3446	291	3	regenerative	regenerative	ADJ
gs-3446	291	4	medicine	medicine	NOUN
gs-3446	291	5	and	and	CCONJ
gs-3446	291	6	disease	disease	NOUN
gs-3446	291	7	the	the	DET
gs-3446	291	8	transcriptional	transcriptional	ADJ
gs-3446	291	9	heterogeneity	heterogeneity	NOUN
gs-3446	291	10	of	of	ADP
gs-3446	291	11	stem	stem	NOUN
gs-3446	291	12	cells	cell	NOUN
gs-3446	291	13	has	have	VERB
gs-3446	291	14	profound	profound	ADJ
gs-3446	291	15	implications	implication	NOUN
gs-3446	291	16	for	for	ADP
gs-3446	291	17	therapeutic	therapeutic	ADJ
gs-3446	291	18	applications	application	NOUN
gs-3446	291	19	.	.	PUNCT
gs-3446	292	1	in	in	ADP
gs-3446	292	2	regenerative	regenerative	ADJ
gs-3446	292	3	medicine	medicine	NOUN
gs-3446	292	4	,	,	PUNCT
gs-3446	292	5	controlling	control	VERB
gs-3446	292	6	transcriptional	transcriptional	ADJ
gs-3446	292	7	circuits	circuit	NOUN
gs-3446	292	8	is	be	AUX
gs-3446	292	9	crucial	crucial	ADJ
gs-3446	292	10	for	for	ADP
gs-3446	292	11	optimizing	optimize	VERB
gs-3446	292	12	directed	direct	VERB
gs-3446	292	13	differentiation	differentiation	NOUN
gs-3446	292	14	protocols	protocol	NOUN
gs-3446	292	15	,	,	PUNCT
gs-3446	292	16	ensuring	ensure	VERB
gs-3446	292	17	stable	stable	ADJ
gs-3446	292	18	cell	cell	NOUN
gs-3446	292	19	fate	fate	NOUN
gs-3446	292	20	commitment	commitment	NOUN
gs-3446	292	21	while	while	SCONJ
gs-3446	292	22	minimizing	minimize	VERB
gs-3446	292	23	variability	variability	NOUN
gs-3446	292	24	.	.	PUNCT
gs-3446	293	1	for	for	ADP
gs-3446	293	2	example	example	NOUN
gs-3446	293	3	,	,	PUNCT
gs-3446	293	4	modulating	modulate	VERB
gs-3446	293	5	the	the	DET
gs-3446	293	6	expression	expression	NOUN
gs-3446	293	7	of	of	ADP
gs-3446	293	8	lineage	lineage	NOUN
gs-3446	293	9	-	-	PUNCT
gs-3446	293	10	specifying	specify	VERB
gs-3446	293	11	transcription	transcription	NOUN
gs-3446	293	12	factors	factor	NOUN
gs-3446	293	13	or	or	CCONJ
gs-3446	293	14	tuning	tune	VERB
gs-3446	293	15	epigenetic	epigenetic	ADJ
gs-3446	293	16	regulators	regulator	NOUN
gs-3446	293	17	could	could	AUX
gs-3446	293	18	improve	improve	VERB
gs-3446	293	19	the	the	DET
gs-3446	293	20	efficiency	efficiency	NOUN
gs-3446	293	21	of	of	ADP
gs-3446	293	22	generating	generate	VERB
gs-3446	293	23	functional	functional	ADJ
gs-3446	293	24	cell	cell	NOUN
gs-3446	293	25	types	type	NOUN
gs-3446	293	26	for	for	ADP
gs-3446	293	27	transplantation	transplantation	NOUN
gs-3446	293	28	(	(	PUNCT
gs-3446	293	29	zare	zare	PROPN
gs-3446	293	30	et	et	PROPN
gs-3446	293	31	al	al	PROPN
gs-3446	293	32	.	.	PROPN
gs-3446	293	33	2023	2023	NUM
gs-3446	293	34	)	)	PUNCT
gs-3446	293	35	.	.	PUNCT
gs-3446	294	1	conversely	conversely	ADV
gs-3446	294	2	,	,	PUNCT
gs-3446	294	3	dysregulation	dysregulation	NOUN
gs-3446	294	4	of	of	ADP
gs-3446	294	5	these	these	DET
gs-3446	294	6	transcriptional	transcriptional	ADJ
gs-3446	294	7	circuits	circuit	NOUN
gs-3446	294	8	can	can	AUX
gs-3446	294	9	contribute	contribute	VERB
gs-3446	294	10	to	to	ADP
gs-3446	294	11	disease	disease	NOUN
gs-3446	294	12	pathogenesis	pathogenesis	NOUN
gs-3446	294	13	,	,	PUNCT
gs-3446	294	14	including	include	VERB
gs-3446	294	15	cancer	cancer	NOUN
gs-3446	294	16	.	.	PUNCT
gs-3446	295	1	many	many	ADJ
gs-3446	295	2	malignancies	malignancy	NOUN
gs-3446	295	3	,	,	PUNCT
gs-3446	295	4	such	such	ADJ
gs-3446	295	5	as	as	ADP
gs-3446	295	6	leukemia	leukemia	NOUN
gs-3446	295	7	and	and	CCONJ
gs-3446	295	8	glioblastoma	glioblastoma	NOUN
gs-3446	295	9	,	,	PUNCT
gs-3446	295	10	hijack	hijack	NOUN
gs-3446	295	11	stem	stem	NOUN
gs-3446	295	12	cell	cell	NOUN
gs-3446	295	13	-	-	PUNCT
gs-3446	295	14	like	like	ADJ
gs-3446	295	15	transcriptional	transcriptional	NOUN
gs-3446	295	16	programs	program	NOUN
gs-3446	295	17	,	,	PUNCT
gs-3446	295	18	leading	lead	VERB
gs-3446	295	19	to	to	ADP
gs-3446	295	20	uncontrolled	uncontrolled	ADJ
gs-3446	295	21	proliferation	proliferation	NOUN
gs-3446	295	22	and	and	CCONJ
gs-3446	295	23	resistance	resistance	NOUN
gs-3446	295	24	to	to	ADP
gs-3446	295	25	differentiation	differentiation	NOUN
gs-3446	295	26	cues	cue	NOUN
gs-3446	295	27	.	.	PUNCT
gs-3446	296	1	georgian	georgian	ADJ
gs-3446	296	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	296	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	296	4	ტ.	ტ.	VERB
gs-3446	296	5	7	7	NUM
gs-3446	296	6	n	n	PRON
gs-3446	296	7	1	1	NUM
gs-3446	296	8	,	,	PUNCT
gs-3446	296	9	2025	2025	NUM
gs-3446	296	10	289	289	NUM
gs-3446	296	11	understanding	understand	VERB
gs-3446	296	12	these	these	DET
gs-3446	296	13	circuits	circuit	NOUN
gs-3446	296	14	in	in	ADP
gs-3446	296	15	normal	normal	ADJ
gs-3446	296	16	stem	stem	NOUN
gs-3446	296	17	cells	cell	NOUN
gs-3446	296	18	can	can	AUX
gs-3446	296	19	therefore	therefore	ADV
gs-3446	296	20	inform	inform	VERB
gs-3446	296	21	strategies	strategy	NOUN
gs-3446	296	22	for	for	ADP
gs-3446	296	23	targeting	target	VERB
gs-3446	296	24	cancer	cancer	NOUN
gs-3446	296	25	stem	stem	NOUN
gs-3446	296	26	cells	cell	NOUN
gs-3446	296	27	.	.	PUNCT
gs-3446	297	1	future	future	ADJ
gs-3446	297	2	directions	direction	NOUN
gs-3446	297	3	recent	recent	ADJ
gs-3446	297	4	advances	advance	NOUN
gs-3446	297	5	in	in	ADP
gs-3446	297	6	single	single	ADJ
gs-3446	297	7	-	-	PUNCT
gs-3446	297	8	cell	cell	NOUN
gs-3446	297	9	transcriptomics	transcriptomic	NOUN
gs-3446	297	10	,	,	PUNCT
gs-3446	297	11	epigenomics	epigenomic	NOUN
gs-3446	297	12	,	,	PUNCT
gs-3446	297	13	and	and	CCONJ
gs-3446	297	14	spatial	spatial	ADJ
gs-3446	297	15	multi	multi	ADJ
gs-3446	297	16	-	-	ADJ
gs-3446	297	17	omics	omic	NOUN
gs-3446	297	18	have	have	AUX
gs-3446	297	19	provided	provide	VERB
gs-3446	297	20	unprecedented	unprecedented	ADJ
gs-3446	297	21	resolution	resolution	NOUN
gs-3446	297	22	into	into	ADP
gs-3446	297	23	stem	stem	NOUN
gs-3446	297	24	cell	cell	NOUN
gs-3446	297	25	heterogeneity	heterogeneity	NOUN
gs-3446	297	26	.	.	PUNCT
gs-3446	298	1	future	future	ADJ
gs-3446	298	2	research	research	NOUN
gs-3446	298	3	should	should	AUX
gs-3446	298	4	focus	focus	VERB
gs-3446	298	5	on	on	ADP
gs-3446	298	6	:	:	PUNCT
gs-3446	298	7	●	●	PUNCT
gs-3446	298	8	deciphering	decipher	VERB
gs-3446	298	9	transcriptional	transcriptional	ADJ
gs-3446	298	10	fluctuations	fluctuation	NOUN
gs-3446	298	11	in	in	ADP
gs-3446	298	12	real	real	ADJ
gs-3446	298	13	-	-	PUNCT
gs-3446	298	14	time	time	NOUN
gs-3446	298	15	using	use	VERB
gs-3446	298	16	live	live	ADJ
gs-3446	298	17	-	-	PUNCT
gs-3446	298	18	cell	cell	NOUN
gs-3446	298	19	imaging	imaging	NOUN
gs-3446	298	20	and	and	CCONJ
gs-3446	298	21	lineage	lineage	NOUN
gs-3446	298	22	tracing	trace	VERB
gs-3446	298	23	.	.	PUNCT
gs-3446	299	1	●	●	PUNCT
gs-3446	299	2	elucidating	elucidate	VERB
gs-3446	299	3	the	the	DET
gs-3446	299	4	role	role	NOUN
gs-3446	299	5	of	of	ADP
gs-3446	299	6	non	non	ADJ
gs-3446	299	7	-	-	ADJ
gs-3446	299	8	coding	coding	ADJ
gs-3446	299	9	rnas	rna	NOUN
gs-3446	299	10	(	(	PUNCT
gs-3446	299	11	e.g.	e.g.	ADV
gs-3446	299	12	,	,	PUNCT
gs-3446	299	13	lncrnas	lncrna	NOUN
gs-3446	299	14	,	,	PUNCT
gs-3446	299	15	mirnas	mirna	NOUN
gs-3446	299	16	)	)	PUNCT
gs-3446	299	17	in	in	ADP
gs-3446	299	18	fine	fine	ADV
gs-3446	299	19	-	-	PUNCT
gs-3446	299	20	tuning	tune	VERB
gs-3446	299	21	stem	stem	NOUN
gs-3446	299	22	cell	cell	NOUN
gs-3446	299	23	fates	fate	NOUN
gs-3446	299	24	.	.	PUNCT
gs-3446	300	1	●	●	PUNCT
gs-3446	300	2	exploring	explore	VERB
gs-3446	300	3	chromatin	chromatin	NOUN
gs-3446	300	4	topology	topology	NOUN
gs-3446	300	5	(	(	PUNCT
gs-3446	300	6	e.g.	e.g.	ADV
gs-3446	300	7	,	,	PUNCT
gs-3446	300	8	3d	3d	NUM
gs-3446	300	9	genome	genome	NOUN
gs-3446	300	10	organization	organization	NOUN
gs-3446	300	11	)	)	PUNCT
gs-3446	300	12	to	to	PART
gs-3446	300	13	understand	understand	VERB
gs-3446	300	14	long	long	ADJ
gs-3446	300	15	-	-	PUNCT
gs-3446	300	16	range	range	NOUN
gs-3446	300	17	transcriptional	transcriptional	ADJ
gs-3446	300	18	regulation	regulation	NOUN
gs-3446	300	19	.	.	PUNCT
gs-3446	301	1	●	●	PUNCT
gs-3446	301	2	developing	develop	VERB
gs-3446	301	3	strategies	strategy	NOUN
gs-3446	301	4	to	to	PART
gs-3446	301	5	manipulate	manipulate	VERB
gs-3446	301	6	transcriptional	transcriptional	ADJ
gs-3446	301	7	circuits	circuit	NOUN
gs-3446	301	8	for	for	ADP
gs-3446	301	9	improved	improved	ADJ
gs-3446	301	10	cell	cell	NOUN
gs-3446	301	11	-	-	PUNCT
gs-3446	301	12	based	base	VERB
gs-3446	301	13	therapies	therapy	NOUN
gs-3446	301	14	.	.	PUNCT
gs-3446	302	1	analysis	analysis	NOUN
gs-3446	302	2	of	of	ADP
gs-3446	302	3	transcriptional	transcriptional	ADJ
gs-3446	302	4	circuits	circuit	NOUN
gs-3446	302	5	in	in	ADP
gs-3446	302	6	stem	stem	NOUN
gs-3446	302	7	cell	cell	NOUN
gs-3446	302	8	heterogeneity	heterogeneity	NOUN
gs-3446	302	9	the	the	DET
gs-3446	302	10	regulation	regulation	NOUN
gs-3446	302	11	of	of	ADP
gs-3446	302	12	stem	stem	NOUN
gs-3446	302	13	cell	cell	NOUN
gs-3446	302	14	heterogeneity	heterogeneity	NOUN
gs-3446	302	15	is	be	AUX
gs-3446	302	16	a	a	DET
gs-3446	302	17	dynamic	dynamic	ADJ
gs-3446	302	18	and	and	CCONJ
gs-3446	302	19	multi	multi	ADJ
gs-3446	302	20	-	-	ADJ
gs-3446	302	21	layered	layered	ADJ
gs-3446	302	22	process	process	NOUN
gs-3446	302	23	controlled	control	VERB
gs-3446	302	24	by	by	ADP
gs-3446	302	25	transcriptional	transcriptional	ADJ
gs-3446	302	26	circuits	circuit	NOUN
gs-3446	302	27	that	that	PRON
gs-3446	302	28	vary	vary	VERB
gs-3446	302	29	across	across	ADP
gs-3446	302	30	different	different	ADJ
gs-3446	302	31	potency	potency	NOUN
gs-3446	302	32	states	state	NOUN
gs-3446	302	33	.	.	PUNCT
gs-3446	303	1	understanding	understand	VERB
gs-3446	303	2	these	these	DET
gs-3446	303	3	networks	network	NOUN
gs-3446	303	4	provides	provide	VERB
gs-3446	303	5	critical	critical	ADJ
gs-3446	303	6	insights	insight	NOUN
gs-3446	303	7	into	into	ADP
gs-3446	303	8	cellular	cellular	ADJ
gs-3446	303	9	plasticity	plasticity	NOUN
gs-3446	303	10	,	,	PUNCT
gs-3446	303	11	lineage	lineage	NOUN
gs-3446	303	12	commitment	commitment	NOUN
gs-3446	303	13	,	,	PUNCT
gs-3446	303	14	and	and	CCONJ
gs-3446	303	15	the	the	DET
gs-3446	303	16	stability	stability	NOUN
gs-3446	303	17	of	of	ADP
gs-3446	303	18	stem	stem	NOUN
gs-3446	303	19	cell	cell	NOUN
gs-3446	303	20	states	state	NOUN
gs-3446	303	21	.	.	PUNCT
gs-3446	304	1	below	below	ADV
gs-3446	304	2	,	,	PUNCT
gs-3446	304	3	we	we	PRON
gs-3446	304	4	analyze	analyze	VERB
gs-3446	304	5	key	key	ADJ
gs-3446	304	6	aspects	aspect	NOUN
gs-3446	304	7	of	of	ADP
gs-3446	304	8	transcriptional	transcriptional	ADJ
gs-3446	304	9	regulation	regulation	NOUN
gs-3446	304	10	in	in	ADP
gs-3446	304	11	pluripotent	pluripotent	NOUN
gs-3446	304	12	,	,	PUNCT
gs-3446	304	13	multipotent	multipotent	NOUN
gs-3446	304	14	,	,	PUNCT
gs-3446	304	15	and	and	CCONJ
gs-3446	304	16	unipotent	unipotent	ADJ
gs-3446	304	17	stem	stem	NOUN
gs-3446	304	18	cells	cell	NOUN
gs-3446	304	19	.	.	PUNCT
gs-3446	305	1	dynamic	dynamic	ADJ
gs-3446	305	2	transcriptional	transcriptional	ADJ
gs-3446	305	3	regulation	regulation	NOUN
gs-3446	305	4	in	in	ADP
gs-3446	305	5	pluripotency	pluripotency	ADJ
gs-3446	305	6	pluripotent	pluripotent	ADJ
gs-3446	305	7	stem	stem	NOUN
gs-3446	305	8	cells	cell	NOUN
gs-3446	305	9	(	(	PUNCT
gs-3446	305	10	pscs	psc	NOUN
gs-3446	305	11	)	)	PUNCT
gs-3446	305	12	are	be	AUX
gs-3446	305	13	characterized	characterize	VERB
gs-3446	305	14	by	by	ADP
gs-3446	305	15	a	a	DET
gs-3446	305	16	fluid	fluid	ADJ
gs-3446	305	17	transcriptional	transcriptional	ADJ
gs-3446	305	18	landscape	landscape	NOUN
gs-3446	305	19	,	,	PUNCT
gs-3446	305	20	where	where	SCONJ
gs-3446	305	21	core	core	NOUN
gs-3446	305	22	factors	factor	NOUN
gs-3446	305	23	(	(	PUNCT
gs-3446	305	24	oct4	oct4	PROPN
gs-3446	305	25	,	,	PUNCT
gs-3446	305	26	sox2	sox2	NOUN
gs-3446	305	27	,	,	PUNCT
gs-3446	305	28	nanog	nanog	PROPN
gs-3446	305	29	)	)	PUNCT
gs-3446	305	30	establish	establish	VERB
gs-3446	305	31	a	a	DET
gs-3446	305	32	self	self	NOUN
gs-3446	305	33	-	-	PUNCT
gs-3446	305	34	renewing	renew	VERB
gs-3446	305	35	state	state	NOUN
gs-3446	305	36	.	.	PUNCT
gs-3446	306	1	however	however	ADV
gs-3446	306	2	,	,	PUNCT
gs-3446	306	3	fluctuations	fluctuation	NOUN
gs-3446	306	4	in	in	ADP
gs-3446	306	5	gene	gene	NOUN
gs-3446	306	6	expression	expression	NOUN
gs-3446	306	7	contribute	contribute	VERB
gs-3446	306	8	to	to	ADP
gs-3446	306	9	heterogeneity	heterogeneity	NOUN
gs-3446	306	10	,	,	PUNCT
gs-3446	306	11	with	with	ADP
gs-3446	306	12	some	some	DET
gs-3446	306	13	cells	cell	NOUN
gs-3446	306	14	exhibiting	exhibit	VERB
gs-3446	306	15	early	early	ADJ
gs-3446	306	16	lineage	lineage	NOUN
gs-3446	306	17	bias	bias	NOUN
gs-3446	306	18	.	.	PUNCT
gs-3446	307	1	single	single	ADJ
gs-3446	307	2	-	-	PUNCT
gs-3446	307	3	cell	cell	NOUN
gs-3446	307	4	rna	rna	NOUN
gs-3446	307	5	sequencing	sequence	VERB
gs-3446	307	6	(	(	PUNCT
gs-3446	307	7	scrna	scrna	NOUN
gs-3446	307	8	-	-	PUNCT
gs-3446	307	9	seq	seq	NOUN
gs-3446	307	10	)	)	PUNCT
gs-3446	307	11	studies	study	NOUN
gs-3446	307	12	confirm	confirm	VERB
gs-3446	307	13	that	that	SCONJ
gs-3446	307	14	psc	psc	PROPN
gs-3446	307	15	populations	population	NOUN
gs-3446	307	16	contain	contain	VERB
gs-3446	307	17	subgroups	subgroup	NOUN
gs-3446	307	18	with	with	ADP
gs-3446	307	19	differential	differential	ADJ
gs-3446	307	20	activation	activation	NOUN
gs-3446	307	21	of	of	ADP
gs-3446	307	22	mesodermal	mesodermal	ADJ
gs-3446	307	23	(	(	PUNCT
gs-3446	307	24	t	t	NOUN
gs-3446	307	25	/	/	SYM
gs-3446	307	26	brachyury	brachyury	NOUN
gs-3446	307	27	)	)	PUNCT
gs-3446	307	28	,	,	PUNCT
gs-3446	307	29	endodermal	endodermal	ADJ
gs-3446	307	30	(	(	PUNCT
gs-3446	307	31	gata6	gata6	PROPN
gs-3446	307	32	)	)	PUNCT
gs-3446	307	33	,	,	PUNCT
gs-3446	307	34	or	or	CCONJ
gs-3446	307	35	ectodermal	ectodermal	ADJ
gs-3446	307	36	(	(	PUNCT
gs-3446	307	37	sox1	sox1	NOUN
gs-3446	307	38	)	)	PUNCT
gs-3446	307	39	markers	marker	NOUN
gs-3446	307	40	,	,	PUNCT
gs-3446	307	41	suggesting	suggest	VERB
gs-3446	307	42	that	that	SCONJ
gs-3446	307	43	fate	fate	NOUN
gs-3446	307	44	decisions	decision	NOUN
gs-3446	307	45	begin	begin	VERB
gs-3446	307	46	at	at	ADP
gs-3446	307	47	the	the	DET
gs-3446	307	48	pluripotent	pluripotent	ADJ
gs-3446	307	49	stage	stage	NOUN
gs-3446	307	50	(	(	PUNCT
gs-3446	307	51	kolodziejczyk	kolodziejczyk	VERB
gs-3446	307	52	et	et	PROPN
gs-3446	307	53	al	al	PROPN
gs-3446	307	54	.	.	PROPN
gs-3446	307	55	2015	2015	NUM
gs-3446	307	56	)	)	PUNCT
gs-3446	307	57	.	.	PUNCT
gs-3446	308	1	from	from	ADP
gs-3446	308	2	an	an	DET
gs-3446	308	3	analytical	analytical	ADJ
gs-3446	308	4	perspective	perspective	NOUN
gs-3446	308	5	,	,	PUNCT
gs-3446	308	6	this	this	DET
gs-3446	308	7	heterogeneity	heterogeneity	NOUN
gs-3446	308	8	can	can	AUX
gs-3446	308	9	be	be	AUX
gs-3446	308	10	viewed	view	VERB
gs-3446	308	11	as	as	ADP
gs-3446	308	12	an	an	DET
gs-3446	308	13	adaptive	adaptive	ADJ
gs-3446	308	14	mechanism	mechanism	NOUN
gs-3446	308	15	that	that	PRON
gs-3446	308	16	enables	enable	VERB
gs-3446	308	17	rapid	rapid	ADJ
gs-3446	308	18	responses	response	NOUN
gs-3446	308	19	to	to	ADP
gs-3446	308	20	differentiation	differentiation	NOUN
gs-3446	308	21	signals	signal	NOUN
gs-3446	308	22	.	.	PUNCT
gs-3446	309	1	rather	rather	ADV
gs-3446	309	2	than	than	ADP
gs-3446	309	3	existing	exist	VERB
gs-3446	309	4	as	as	ADP
gs-3446	309	5	a	a	DET
gs-3446	309	6	uniform	uniform	ADJ
gs-3446	309	7	population	population	NOUN
gs-3446	309	8	,	,	PUNCT
gs-3446	309	9	pluripotent	pluripotent	ADJ
gs-3446	309	10	cells	cell	NOUN
gs-3446	309	11	dynamically	dynamically	ADV
gs-3446	309	12	explore	explore	VERB
gs-3446	309	13	different	different	ADJ
gs-3446	309	14	transcriptional	transcriptional	ADJ
gs-3446	309	15	states	state	NOUN
gs-3446	309	16	,	,	PUNCT
gs-3446	309	17	increasing	increase	VERB
gs-3446	309	18	their	their	PRON
gs-3446	309	19	ability	ability	NOUN
gs-3446	309	20	to	to	PART
gs-3446	309	21	commit	commit	VERB
gs-3446	309	22	to	to	ADP
gs-3446	309	23	specific	specific	ADJ
gs-3446	309	24	lineages	lineage	NOUN
gs-3446	309	25	when	when	SCONJ
gs-3446	309	26	required	require	VERB
gs-3446	309	27	.	.	PUNCT
gs-3446	310	1	however	however	ADV
gs-3446	310	2	,	,	PUNCT
gs-3446	310	3	this	this	DET
gs-3446	310	4	variability	variability	NOUN
gs-3446	310	5	also	also	ADV
gs-3446	310	6	presents	present	VERB
gs-3446	310	7	challenges	challenge	NOUN
gs-3446	310	8	for	for	ADP
gs-3446	310	9	directed	direct	VERB
gs-3446	310	10	differentiation	differentiation	NOUN
gs-3446	310	11	in	in	ADP
gs-3446	310	12	regenerative	regenerative	ADJ
gs-3446	310	13	medicine	medicine	NOUN
gs-3446	310	14	,	,	PUNCT
gs-3446	310	15	as	as	SCONJ
gs-3446	310	16	uncontrolled	uncontrolled	ADJ
gs-3446	310	17	lineage	lineage	NOUN
gs-3446	310	18	priming	priming	NOUN
gs-3446	310	19	can	can	AUX
gs-3446	310	20	lead	lead	VERB
gs-3446	310	21	to	to	ADP
gs-3446	310	22	heterogeneous	heterogeneous	ADJ
gs-3446	310	23	cell	cell	NOUN
gs-3446	310	24	populations	population	NOUN
gs-3446	310	25	unsuitable	unsuitable	ADJ
gs-3446	310	26	for	for	ADP
gs-3446	310	27	therapeutic	therapeutic	ADJ
gs-3446	310	28	applications	application	NOUN
gs-3446	310	29	.	.	PUNCT
gs-3446	311	1	georgian	georgian	ADJ
gs-3446	311	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	311	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	311	4	ტ.	ტ.	VERB
gs-3446	311	5	7	7	NUM
gs-3446	311	6	n	n	PRON
gs-3446	311	7	1	1	NUM
gs-3446	311	8	,	,	PUNCT
gs-3446	311	9	2025	2025	NUM
gs-3446	311	10	290	290	NUM
gs-3446	311	11	multipotent	multipotent	NOUN
gs-3446	311	12	stem	stem	NOUN
gs-3446	311	13	cells	cell	NOUN
gs-3446	311	14	:	:	PUNCT
gs-3446	311	15	gradual	gradual	ADJ
gs-3446	311	16	lineage	lineage	NOUN
gs-3446	311	17	restriction	restriction	NOUN
gs-3446	311	18	in	in	ADP
gs-3446	311	19	multipotent	multipotent	NOUN
gs-3446	311	20	stem	stem	NOUN
gs-3446	311	21	cells	cell	NOUN
gs-3446	311	22	,	,	PUNCT
gs-3446	311	23	transcriptional	transcriptional	ADJ
gs-3446	311	24	regulation	regulation	NOUN
gs-3446	311	25	becomes	become	VERB
gs-3446	311	26	more	more	ADV
gs-3446	311	27	constrained	constrain	VERB
gs-3446	311	28	,	,	PUNCT
gs-3446	311	29	with	with	ADP
gs-3446	311	30	lineage	lineage	NOUN
gs-3446	311	31	-	-	PUNCT
gs-3446	311	32	specific	specific	ADJ
gs-3446	311	33	transcription	transcription	NOUN
gs-3446	311	34	factors	factor	NOUN
gs-3446	311	35	(	(	PUNCT
gs-3446	311	36	tfs	tfs	PROPN
gs-3446	311	37	)	)	PUNCT
gs-3446	311	38	exerting	exert	VERB
gs-3446	311	39	greater	great	ADJ
gs-3446	311	40	influence	influence	NOUN
gs-3446	311	41	over	over	ADP
gs-3446	311	42	fate	fate	NOUN
gs-3446	311	43	decisions	decision	NOUN
gs-3446	311	44	.	.	PUNCT
gs-3446	312	1	for	for	ADP
gs-3446	312	2	example	example	NOUN
gs-3446	312	3	,	,	PUNCT
gs-3446	312	4	hematopoietic	hematopoietic	ADJ
gs-3446	312	5	stem	stem	NOUN
gs-3446	312	6	cells	cell	NOUN
gs-3446	312	7	(	(	PUNCT
gs-3446	312	8	hscs	hsc	NOUN
gs-3446	312	9	)	)	PUNCT
gs-3446	312	10	rely	rely	VERB
gs-3446	312	11	on	on	ADP
gs-3446	312	12	gata2	gata2	PROPN
gs-3446	312	13	and	and	CCONJ
gs-3446	312	14	runx1	runx1	NOUN
gs-3446	312	15	to	to	PART
gs-3446	312	16	maintain	maintain	VERB
gs-3446	312	17	their	their	PRON
gs-3446	312	18	multipotent	multipotent	NOUN
gs-3446	312	19	state	state	NOUN
gs-3446	312	20	,	,	PUNCT
gs-3446	312	21	but	but	CCONJ
gs-3446	312	22	as	as	ADP
gs-3446	312	23	differentiation	differentiation	NOUN
gs-3446	312	24	progresses	progress	NOUN
gs-3446	312	25	,	,	PUNCT
gs-3446	312	26	lineage	lineage	NOUN
gs-3446	312	27	-	-	PUNCT
gs-3446	312	28	restricted	restrict	VERB
gs-3446	312	29	tfs	tfs	NOUN
gs-3446	312	30	like	like	ADP
gs-3446	312	31	pu.1	pu.1	PROPN
gs-3446	312	32	(	(	PUNCT
gs-3446	312	33	myeloid	myeloid	NOUN
gs-3446	312	34	)	)	PUNCT
gs-3446	312	35	and	and	CCONJ
gs-3446	312	36	gata1	gata1	NOUN
gs-3446	312	37	(	(	PUNCT
gs-3446	312	38	erythroid	erythroid	ADJ
gs-3446	312	39	)	)	PUNCT
gs-3446	312	40	solidify	solidify	VERB
gs-3446	312	41	cell	cell	NOUN
gs-3446	312	42	fate	fate	NOUN
gs-3446	312	43	.	.	PUNCT
gs-3446	313	1	similar	similar	ADJ
gs-3446	313	2	mechanisms	mechanism	NOUN
gs-3446	313	3	are	be	AUX
gs-3446	313	4	seen	see	VERB
gs-3446	313	5	in	in	ADP
gs-3446	313	6	neural	neural	ADJ
gs-3446	313	7	and	and	CCONJ
gs-3446	313	8	mesenchymal	mesenchymal	ADJ
gs-3446	313	9	stem	stem	NOUN
gs-3446	313	10	cells	cell	NOUN
gs-3446	313	11	,	,	PUNCT
gs-3446	313	12	where	where	SCONJ
gs-3446	313	13	lineage	lineage	NOUN
gs-3446	313	14	priming	priming	NOUN
gs-3446	313	15	is	be	AUX
gs-3446	313	16	reinforced	reinforce	VERB
gs-3446	313	17	by	by	ADP
gs-3446	313	18	epigenetic	epigenetic	ADJ
gs-3446	313	19	regulators	regulator	NOUN
gs-3446	313	20	such	such	ADJ
gs-3446	313	21	as	as	ADP
gs-3446	313	22	polycomb	polycomb	ADJ
gs-3446	313	23	repressive	repressive	ADJ
gs-3446	313	24	complexes	complex	NOUN
gs-3446	313	25	(	(	PUNCT
gs-3446	313	26	prc1/2	prc1/2	NUM
gs-3446	313	27	)	)	PUNCT
gs-3446	313	28	and	and	CCONJ
gs-3446	313	29	trithorax	trithorax	PROPN
gs-3446	313	30	group	group	NOUN
gs-3446	313	31	proteins	protein	NOUN
gs-3446	313	32	(	(	PUNCT
gs-3446	313	33	zare	zare	PROPN
gs-3446	313	34	et	et	PROPN
gs-3446	313	35	al	al	PROPN
gs-3446	313	36	.	.	PROPN
gs-3446	313	37	2023	2023	NUM
gs-3446	313	38	)	)	PUNCT
gs-3446	313	39	.	.	PUNCT
gs-3446	314	1	a	a	DET
gs-3446	314	2	key	key	ADJ
gs-3446	314	3	analytical	analytical	ADJ
gs-3446	314	4	takeaway	takeaway	NOUN
gs-3446	314	5	is	be	AUX
gs-3446	314	6	that	that	DET
gs-3446	314	7	multipotency	multipotency	NOUN
gs-3446	314	8	is	be	AUX
gs-3446	314	9	not	not	PART
gs-3446	314	10	a	a	DET
gs-3446	314	11	static	static	ADJ
gs-3446	314	12	state	state	NOUN
gs-3446	314	13	but	but	CCONJ
gs-3446	314	14	rather	rather	ADV
gs-3446	314	15	a	a	DET
gs-3446	314	16	transition	transition	NOUN
gs-3446	314	17	phase	phase	NOUN
gs-3446	314	18	characterized	characterize	VERB
gs-3446	314	19	by	by	ADP
gs-3446	314	20	lineage	lineage	NOUN
gs-3446	314	21	-	-	PUNCT
gs-3446	314	22	priming	prime	VERB
gs-3446	314	23	events	event	NOUN
gs-3446	314	24	.	.	PUNCT
gs-3446	315	1	studies	study	NOUN
gs-3446	315	2	using	use	VERB
gs-3446	315	3	chromatin	chromatin	NOUN
gs-3446	315	4	accessibility	accessibility	NOUN
gs-3446	315	5	assays	assay	NOUN
gs-3446	315	6	(	(	PUNCT
gs-3446	315	7	atac	atac	NOUN
gs-3446	315	8	-	-	PUNCT
gs-3446	315	9	seq	seq	NOUN
gs-3446	315	10	,	,	PUNCT
gs-3446	315	11	chip	chip	NOUN
gs-3446	315	12	-	-	PUNCT
gs-3446	315	13	seq	seq	NOUN
gs-3446	315	14	)	)	PUNCT
gs-3446	315	15	demonstrate	demonstrate	VERB
gs-3446	315	16	that	that	SCONJ
gs-3446	315	17	multipotent	multipotent	NOUN
gs-3446	315	18	stem	stem	NOUN
gs-3446	315	19	cells	cell	NOUN
gs-3446	315	20	progressively	progressively	ADV
gs-3446	315	21	lose	lose	VERB
gs-3446	315	22	the	the	DET
gs-3446	315	23	ability	ability	NOUN
gs-3446	315	24	to	to	PART
gs-3446	315	25	activate	activate	VERB
gs-3446	315	26	alternative	alternative	ADJ
gs-3446	315	27	lineage	lineage	NOUN
gs-3446	315	28	programs	program	NOUN
gs-3446	315	29	as	as	ADP
gs-3446	315	30	differentiation	differentiation	NOUN
gs-3446	315	31	proceeds	proceed	NOUN
gs-3446	315	32	.	.	PUNCT
gs-3446	316	1	this	this	PRON
gs-3446	316	2	suggests	suggest	VERB
gs-3446	316	3	that	that	SCONJ
gs-3446	316	4	stem	stem	NOUN
gs-3446	316	5	cell	cell	NOUN
gs-3446	316	6	differentiation	differentiation	NOUN
gs-3446	316	7	is	be	AUX
gs-3446	316	8	a	a	DET
gs-3446	316	9	continuum	continuum	ADJ
gs-3446	316	10	rather	rather	ADV
gs-3446	316	11	than	than	ADP
gs-3446	316	12	a	a	DET
gs-3446	316	13	binary	binary	ADJ
gs-3446	316	14	switch	switch	NOUN
gs-3446	316	15	,	,	PUNCT
gs-3446	316	16	where	where	SCONJ
gs-3446	316	17	transcriptional	transcriptional	ADJ
gs-3446	316	18	circuits	circuit	NOUN
gs-3446	316	19	gradually	gradually	ADV
gs-3446	316	20	shift	shift	VERB
gs-3446	316	21	from	from	ADP
gs-3446	316	22	multipotency	multipotency	NOUN
gs-3446	316	23	to	to	ADP
gs-3446	316	24	lineage	lineage	NOUN
gs-3446	316	25	commitment	commitment	NOUN
gs-3446	316	26	.	.	PUNCT
gs-3446	317	1	unipotency	unipotency	NOUN
gs-3446	317	2	:	:	PUNCT
gs-3446	317	3	commitment	commitment	NOUN
gs-3446	317	4	and	and	CCONJ
gs-3446	317	5	stability	stability	NOUN
gs-3446	317	6	in	in	ADP
gs-3446	317	7	unipotent	unipotent	ADJ
gs-3446	317	8	stem	stem	NOUN
gs-3446	317	9	cells	cell	NOUN
gs-3446	317	10	,	,	PUNCT
gs-3446	317	11	transcriptional	transcriptional	ADJ
gs-3446	317	12	circuits	circuit	NOUN
gs-3446	317	13	become	become	VERB
gs-3446	317	14	highly	highly	ADV
gs-3446	317	15	restrictive	restrictive	ADJ
gs-3446	317	16	,	,	PUNCT
gs-3446	317	17	locking	locking	NOUN
gs-3446	317	18	cells	cell	NOUN
gs-3446	317	19	into	into	ADP
gs-3446	317	20	a	a	DET
gs-3446	317	21	single	single	ADJ
gs-3446	317	22	fate	fate	NOUN
gs-3446	317	23	.	.	PUNCT
gs-3446	318	1	for	for	ADP
gs-3446	318	2	instance	instance	NOUN
gs-3446	318	3	,	,	PUNCT
gs-3446	318	4	in	in	ADP
gs-3446	318	5	muscle	muscle	NOUN
gs-3446	318	6	satellite	satellite	NOUN
gs-3446	318	7	cells	cell	NOUN
gs-3446	318	8	,	,	PUNCT
gs-3446	318	9	pax7	pax7	NOUN
gs-3446	318	10	and	and	CCONJ
gs-3446	318	11	myod1	myod1	NOUN
gs-3446	318	12	establish	establish	VERB
gs-3446	318	13	a	a	DET
gs-3446	318	14	transcriptional	transcriptional	ADJ
gs-3446	318	15	hierarchy	hierarchy	NOUN
gs-3446	318	16	that	that	PRON
gs-3446	318	17	maintains	maintain	VERB
gs-3446	318	18	self	self	NOUN
gs-3446	318	19	-	-	PUNCT
gs-3446	318	20	renewal	renewal	NOUN
gs-3446	318	21	while	while	SCONJ
gs-3446	318	22	allowing	allow	VERB
gs-3446	318	23	differentiation	differentiation	NOUN
gs-3446	318	24	into	into	ADP
gs-3446	318	25	myogenic	myogenic	ADJ
gs-3446	318	26	lineages	lineage	NOUN
gs-3446	318	27	.	.	PUNCT
gs-3446	319	1	in	in	ADP
gs-3446	319	2	epidermal	epidermal	ADJ
gs-3446	319	3	stem	stem	NOUN
gs-3446	319	4	cells	cell	NOUN
gs-3446	319	5	,	,	PUNCT
gs-3446	319	6	tp63	tp63	PROPN
gs-3446	319	7	and	and	CCONJ
gs-3446	319	8	klf4	klf4	PROPN
gs-3446	319	9	enforce	enforce	VERB
gs-3446	319	10	epidermal	epidermal	ADJ
gs-3446	319	11	identity	identity	NOUN
gs-3446	319	12	while	while	SCONJ
gs-3446	319	13	suppressing	suppress	VERB
gs-3446	319	14	alternative	alternative	ADJ
gs-3446	319	15	fates	fate	NOUN
gs-3446	319	16	(	(	PUNCT
gs-3446	319	17	aphkhazava	aphkhazava	NOUN
gs-3446	319	18	et	et	PROPN
gs-3446	319	19	al	al	PROPN
gs-3446	319	20	.	.	PROPN
gs-3446	319	21	2023	2023	NUM
gs-3446	319	22	)	)	PUNCT
gs-3446	319	23	.	.	PUNCT
gs-3446	320	1	an	an	DET
gs-3446	320	2	important	important	ADJ
gs-3446	320	3	consideration	consideration	NOUN
gs-3446	320	4	is	be	AUX
gs-3446	320	5	whether	whether	SCONJ
gs-3446	320	6	unipotency	unipotency	NOUN
gs-3446	320	7	represents	represent	VERB
gs-3446	320	8	an	an	DET
gs-3446	320	9	irreversible	irreversible	ADJ
gs-3446	320	10	endpoint	endpoint	NOUN
gs-3446	320	11	or	or	CCONJ
gs-3446	320	12	if	if	SCONJ
gs-3446	320	13	certain	certain	ADJ
gs-3446	320	14	conditions	condition	NOUN
gs-3446	320	15	allow	allow	VERB
gs-3446	320	16	for	for	ADP
gs-3446	320	17	reprogramming	reprogramme	VERB
gs-3446	320	18	.	.	PUNCT
gs-3446	321	1	recent	recent	ADJ
gs-3446	321	2	findings	finding	NOUN
gs-3446	321	3	suggest	suggest	VERB
gs-3446	321	4	that	that	SCONJ
gs-3446	321	5	some	some	DET
gs-3446	321	6	unipotent	unipotent	ADJ
gs-3446	321	7	stem	stem	NOUN
gs-3446	321	8	cells	cell	NOUN
gs-3446	321	9	exhibit	exhibit	VERB
gs-3446	321	10	latent	latent	NOUN
gs-3446	321	11	plasticity	plasticity	NOUN
gs-3446	321	12	,	,	PUNCT
gs-3446	321	13	particularly	particularly	ADV
gs-3446	321	14	in	in	ADP
gs-3446	321	15	response	response	NOUN
gs-3446	321	16	to	to	ADP
gs-3446	321	17	injury	injury	NOUN
gs-3446	321	18	.	.	PUNCT
gs-3446	322	1	for	for	ADP
gs-3446	322	2	example	example	NOUN
gs-3446	322	3	,	,	PUNCT
gs-3446	322	4	intestinal	intestinal	ADJ
gs-3446	322	5	stem	stem	NOUN
gs-3446	322	6	cells	cell	NOUN
gs-3446	322	7	can	can	AUX
gs-3446	322	8	revert	revert	VERB
gs-3446	322	9	to	to	ADP
gs-3446	322	10	a	a	DET
gs-3446	322	11	more	more	ADV
gs-3446	322	12	progenitor	progenitor	NOUN
gs-3446	322	13	-	-	PUNCT
gs-3446	322	14	like	like	ADJ
gs-3446	322	15	state	state	NOUN
gs-3446	322	16	under	under	ADP
gs-3446	322	17	regenerative	regenerative	ADJ
gs-3446	322	18	conditions	condition	NOUN
gs-3446	322	19	,	,	PUNCT
gs-3446	322	20	suggesting	suggest	VERB
gs-3446	322	21	that	that	SCONJ
gs-3446	322	22	transcriptional	transcriptional	ADJ
gs-3446	322	23	circuits	circuit	NOUN
gs-3446	322	24	,	,	PUNCT
gs-3446	322	25	while	while	SCONJ
gs-3446	322	26	restrictive	restrictive	ADJ
gs-3446	322	27	,	,	PUNCT
gs-3446	322	28	retain	retain	VERB
gs-3446	322	29	a	a	DET
gs-3446	322	30	degree	degree	NOUN
gs-3446	322	31	of	of	ADP
gs-3446	322	32	reversibility	reversibility	NOUN
gs-3446	322	33	under	under	ADP
gs-3446	322	34	specific	specific	ADJ
gs-3446	322	35	stimuli	stimulus	NOUN
gs-3446	322	36	.	.	PUNCT
gs-3446	323	1	transcriptional	transcriptional	ADJ
gs-3446	323	2	circuits	circuit	NOUN
gs-3446	323	3	and	and	CCONJ
gs-3446	323	4	disease	disease	NOUN
gs-3446	323	5	dysregulation	dysregulation	NOUN
gs-3446	323	6	of	of	ADP
gs-3446	323	7	transcriptional	transcriptional	ADJ
gs-3446	323	8	networks	network	NOUN
gs-3446	323	9	can	can	AUX
gs-3446	323	10	contribute	contribute	VERB
gs-3446	323	11	to	to	ADP
gs-3446	323	12	pathological	pathological	ADJ
gs-3446	323	13	conditions	condition	NOUN
gs-3446	323	14	,	,	PUNCT
gs-3446	323	15	including	include	VERB
gs-3446	323	16	cancer	cancer	NOUN
gs-3446	323	17	.	.	PUNCT
gs-3446	324	1	cancer	cancer	NOUN
gs-3446	324	2	stem	stem	NOUN
gs-3446	324	3	cells	cell	NOUN
gs-3446	324	4	(	(	PUNCT
gs-3446	324	5	cscs	cscs	PROPN
gs-3446	324	6	)	)	PUNCT
gs-3446	324	7	often	often	ADV
gs-3446	324	8	hijack	hijack	VERB
gs-3446	324	9	stem	stem	NOUN
gs-3446	324	10	cell	cell	NOUN
gs-3446	324	11	-	-	PUNCT
gs-3446	324	12	like	like	ADJ
gs-3446	324	13	transcriptional	transcriptional	NOUN
gs-3446	324	14	programs	program	NOUN
gs-3446	324	15	,	,	PUNCT
gs-3446	324	16	leading	lead	VERB
gs-3446	324	17	to	to	ADP
gs-3446	324	18	uncontrolled	uncontrolled	ADJ
gs-3446	324	19	proliferation	proliferation	NOUN
gs-3446	324	20	and	and	CCONJ
gs-3446	324	21	resistance	resistance	NOUN
gs-3446	324	22	to	to	ADP
gs-3446	324	23	differentiation	differentiation	NOUN
gs-3446	324	24	cues	cue	NOUN
gs-3446	324	25	.	.	PUNCT
gs-3446	325	1	in	in	ADP
gs-3446	325	2	leukemia	leukemia	NOUN
gs-3446	325	3	,	,	PUNCT
gs-3446	325	4	aberrant	aberrant	ADJ
gs-3446	325	5	activation	activation	NOUN
gs-3446	325	6	of	of	ADP
gs-3446	325	7	pluripotencyassociated	pluripotencyassociate	VERB
gs-3446	325	8	tfs	tfs	PROPN
gs-3446	325	9	(	(	PUNCT
gs-3446	325	10	e.g.	e.g.	ADV
gs-3446	325	11	,	,	PUNCT
gs-3446	325	12	nanog	nanog	PROPN
gs-3446	325	13	,	,	PUNCT
gs-3446	325	14	sox2	sox2	NOUN
gs-3446	325	15	,	,	PUNCT
gs-3446	325	16	and	and	CCONJ
gs-3446	325	17	myc	myc	PROPN
gs-3446	325	18	)	)	PUNCT
gs-3446	325	19	contributes	contribute	VERB
gs-3446	325	20	to	to	ADP
gs-3446	325	21	stemness	stemness	NOUN
gs-3446	325	22	-	-	PUNCT
gs-3446	325	23	like	like	ADJ
gs-3446	325	24	properties	property	NOUN
gs-3446	325	25	in	in	ADP
gs-3446	325	26	malignant	malignant	ADJ
gs-3446	325	27	cells	cell	NOUN
gs-3446	325	28	.	.	PUNCT
gs-3446	326	1	similarly	similarly	ADV
gs-3446	326	2	,	,	PUNCT
gs-3446	326	3	glioblastoma	glioblastoma	NOUN
gs-3446	326	4	stem	stem	NOUN
gs-3446	326	5	-	-	PUNCT
gs-3446	326	6	like	like	ADJ
gs-3446	326	7	cells	cell	NOUN
gs-3446	326	8	exploit	exploit	VERB
gs-3446	326	9	sox2	sox2	NOUN
gs-3446	326	10	and	and	CCONJ
gs-3446	326	11	olig2	olig2	NOUN
gs-3446	326	12	to	to	PART
gs-3446	326	13	sustain	sustain	VERB
gs-3446	326	14	an	an	DET
gs-3446	326	15	undifferentiated	undifferentiated	ADJ
gs-3446	326	16	state	state	NOUN
gs-3446	326	17	.	.	PUNCT
gs-3446	327	1	from	from	ADP
gs-3446	327	2	an	an	DET
gs-3446	327	3	analytical	analytical	ADJ
gs-3446	327	4	perspective	perspective	NOUN
gs-3446	327	5	,	,	PUNCT
gs-3446	327	6	cancer	cancer	NOUN
gs-3446	327	7	stem	stem	NOUN
gs-3446	327	8	cells	cell	NOUN
gs-3446	327	9	illustrate	illustrate	VERB
gs-3446	327	10	how	how	SCONJ
gs-3446	327	11	transcriptional	transcriptional	ADJ
gs-3446	327	12	circuits	circuit	NOUN
gs-3446	327	13	can	can	AUX
gs-3446	327	14	be	be	AUX
gs-3446	327	15	reactivated	reactivate	VERB
gs-3446	327	16	or	or	CCONJ
gs-3446	327	17	dysregulated	dysregulate	VERB
gs-3446	327	18	to	to	PART
gs-3446	327	19	promote	promote	VERB
gs-3446	327	20	tumor	tumor	NOUN
gs-3446	327	21	progression	progression	NOUN
gs-3446	327	22	.	.	PUNCT
gs-3446	328	1	this	this	PRON
gs-3446	328	2	highlights	highlight	VERB
gs-3446	328	3	the	the	DET
gs-3446	328	4	importance	importance	NOUN
gs-3446	328	5	of	of	ADP
gs-3446	328	6	targeting	target	VERB
gs-3446	328	7	georgian	georgian	ADJ
gs-3446	328	8	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3446	328	9	მეცნიერები	მეცნიერები	NOUN
gs-3446	328	10	ტ.	ტ.	VERB
gs-3446	328	11	7	7	NUM
gs-3446	328	12	n	n	PRON
gs-3446	328	13	1	1	NUM
gs-3446	328	14	,	,	PUNCT
gs-3446	328	15	2025	2025	NUM
gs-3446	328	16	291	291	NUM
gs-3446	328	17	transcriptional	transcriptional	ADJ
gs-3446	328	18	regulators	regulator	NOUN
gs-3446	328	19	or	or	CCONJ
gs-3446	328	20	epigenetic	epigenetic	ADJ
gs-3446	328	21	modulators	modulator	NOUN
gs-3446	328	22	(	(	PUNCT
gs-3446	328	23	e.g.	e.g.	ADV
gs-3446	328	24	,	,	PUNCT
gs-3446	328	25	histone	histone	NOUN
gs-3446	328	26	deacetylase	deacetylase	VERB
gs-3446	328	27	inhibitors	inhibitor	NOUN
gs-3446	328	28	,	,	PUNCT
gs-3446	328	29	dna	dna	PROPN
gs-3446	328	30	methylation	methylation	NOUN
gs-3446	328	31	blockers	blocker	NOUN
gs-3446	328	32	)	)	PUNCT
gs-3446	328	33	as	as	ADP
gs-3446	328	34	potential	potential	ADJ
gs-3446	328	35	therapeutic	therapeutic	ADJ
gs-3446	328	36	strategies	strategy	NOUN
gs-3446	328	37	to	to	PART
gs-3446	328	38	force	force	VERB
gs-3446	328	39	differentiation	differentiation	NOUN
gs-3446	328	40	and	and	CCONJ
gs-3446	328	41	reduce	reduce	VERB
gs-3446	328	42	tumorinitiating	tumorinitiate	VERB
gs-3446	328	43	potential	potential	NOUN
gs-3446	328	44	(	(	PUNCT
gs-3446	328	45	zare	zare	PROPN
gs-3446	328	46	et	et	PROPN
gs-3446	328	47	al	al	PROPN
gs-3446	328	48	.	.	PROPN
gs-3446	328	49	2023	2023	NUM
gs-3446	328	50	)	)	PUNCT
gs-3446	328	51	.	.	PUNCT
gs-3446	329	1	implications	implication	NOUN
gs-3446	329	2	for	for	ADP
gs-3446	329	3	regenerative	regenerative	ADJ
gs-3446	329	4	medicine	medicine	NOUN
gs-3446	329	5	the	the	DET
gs-3446	329	6	ability	ability	NOUN
gs-3446	329	7	to	to	PART
gs-3446	329	8	manipulate	manipulate	VERB
gs-3446	329	9	transcriptional	transcriptional	ADJ
gs-3446	329	10	circuits	circuit	NOUN
gs-3446	329	11	holds	hold	VERB
gs-3446	329	12	significant	significant	ADJ
gs-3446	329	13	promise	promise	NOUN
gs-3446	329	14	for	for	ADP
gs-3446	329	15	regenerative	regenerative	ADJ
gs-3446	329	16	medicine	medicine	NOUN
gs-3446	329	17	.	.	PUNCT
gs-3446	330	1	by	by	ADP
gs-3446	330	2	modulating	modulate	VERB
gs-3446	330	3	key	key	ADJ
gs-3446	330	4	transcription	transcription	NOUN
gs-3446	330	5	factors	factor	NOUN
gs-3446	330	6	,	,	PUNCT
gs-3446	330	7	it	it	PRON
gs-3446	330	8	is	be	AUX
gs-3446	330	9	possible	possible	ADJ
gs-3446	330	10	to	to	PART
gs-3446	330	11	direct	direct	ADJ
gs-3446	330	12	stem	stem	NOUN
gs-3446	330	13	cell	cell	NOUN
gs-3446	330	14	differentiation	differentiation	NOUN
gs-3446	330	15	with	with	ADP
gs-3446	330	16	greater	great	ADJ
gs-3446	330	17	precision	precision	NOUN
gs-3446	330	18	.	.	PUNCT
gs-3446	331	1	for	for	ADP
gs-3446	331	2	instance	instance	NOUN
gs-3446	331	3	:	:	PUNCT
gs-3446	331	4	●	●	NUM
gs-3446	331	5	forced	force	VERB
gs-3446	331	6	expression	expression	NOUN
gs-3446	331	7	of	of	ADP
gs-3446	331	8	myod1	myod1	NOUN
gs-3446	331	9	can	can	AUX
gs-3446	331	10	reprogram	reprogram	VERB
gs-3446	331	11	fibroblasts	fibroblast	NOUN
gs-3446	331	12	into	into	ADP
gs-3446	331	13	muscle	muscle	NOUN
gs-3446	331	14	cells	cell	NOUN
gs-3446	331	15	.	.	PUNCT
gs-3446	332	1	●	●	PUNCT
gs-3446	332	2	overexpression	overexpression	NOUN
gs-3446	332	3	of	of	ADP
gs-3446	332	4	sox2	sox2	NOUN
gs-3446	332	5	and	and	CCONJ
gs-3446	332	6	pax6	pax6	NOUN
gs-3446	332	7	can	can	AUX
gs-3446	332	8	induce	induce	VERB
gs-3446	332	9	neural	neural	ADJ
gs-3446	332	10	differentiation	differentiation	NOUN
gs-3446	332	11	.	.	PUNCT
gs-3446	333	1	●	●	PUNCT
gs-3446	333	2	inhibition	inhibition	NOUN
gs-3446	333	3	of	of	ADP
gs-3446	333	4	lineage	lineage	NOUN
gs-3446	333	5	-	-	PUNCT
gs-3446	333	6	restricting	restrict	VERB
gs-3446	333	7	factors	factor	NOUN
gs-3446	333	8	(	(	PUNCT
gs-3446	333	9	e.g.	e.g.	ADV
gs-3446	333	10	,	,	PUNCT
gs-3446	333	11	rest	rest	VERB
gs-3446	333	12	in	in	ADP
gs-3446	333	13	neural	neural	ADJ
gs-3446	333	14	differentiation	differentiation	NOUN
gs-3446	333	15	)	)	PUNCT
gs-3446	333	16	can	can	AUX
gs-3446	333	17	enhance	enhance	VERB
gs-3446	333	18	plasticity	plasticity	NOUN
gs-3446	333	19	.	.	PUNCT
gs-3446	334	1	however	however	ADV
gs-3446	334	2	,	,	PUNCT
gs-3446	334	3	the	the	DET
gs-3446	334	4	challenge	challenge	NOUN
gs-3446	334	5	lies	lie	VERB
gs-3446	334	6	in	in	ADP
gs-3446	334	7	maintaining	maintain	VERB
gs-3446	334	8	stability	stability	NOUN
gs-3446	334	9	and	and	CCONJ
gs-3446	334	10	functionality	functionality	NOUN
gs-3446	334	11	of	of	ADP
gs-3446	334	12	the	the	DET
gs-3446	334	13	differentiated	differentiated	ADJ
gs-3446	334	14	cells	cell	NOUN
gs-3446	334	15	.	.	PUNCT
gs-3446	335	1	many	many	ADJ
gs-3446	335	2	stem	stem	NOUN
gs-3446	335	3	cell	cell	NOUN
gs-3446	335	4	-	-	PUNCT
gs-3446	335	5	derived	derive	VERB
gs-3446	335	6	cell	cell	NOUN
gs-3446	335	7	types	type	NOUN
gs-3446	335	8	fail	fail	VERB
gs-3446	335	9	to	to	PART
gs-3446	335	10	fully	fully	ADV
gs-3446	335	11	recapitulate	recapitulate	VERB
gs-3446	335	12	the	the	DET
gs-3446	335	13	gene	gene	NOUN
gs-3446	335	14	expression	expression	NOUN
gs-3446	335	15	and	and	CCONJ
gs-3446	335	16	functionality	functionality	NOUN
gs-3446	335	17	of	of	ADP
gs-3446	335	18	their	their	PRON
gs-3446	335	19	in	in	ADP
gs-3446	335	20	vivo	vivo	ADJ
gs-3446	335	21	counterparts	counterpart	NOUN
gs-3446	335	22	,	,	PUNCT
gs-3446	335	23	underscoring	underscore	VERB
gs-3446	335	24	the	the	DET
gs-3446	335	25	need	need	NOUN
gs-3446	335	26	for	for	ADP
gs-3446	335	27	more	more	ADJ
gs-3446	335	28	refined	refined	ADJ
gs-3446	335	29	approaches	approach	NOUN
gs-3446	335	30	,	,	PUNCT
gs-3446	335	31	such	such	ADJ
gs-3446	335	32	as	as	ADP
gs-3446	335	33	3d	3d	PROPN
gs-3446	335	34	organoid	organoid	PROPN
gs-3446	335	35	models	model	NOUN
gs-3446	335	36	,	,	PUNCT
gs-3446	335	37	co	co	ADJ
gs-3446	335	38	-	-	NOUN
gs-3446	335	39	culture	culture	NOUN
gs-3446	335	40	systems	system	NOUN
gs-3446	335	41	,	,	PUNCT
gs-3446	335	42	and	and	CCONJ
gs-3446	335	43	biomaterial	biomaterial	ADJ
gs-3446	335	44	scaffolds	scaffold	NOUN
gs-3446	335	45	to	to	PART
gs-3446	335	46	better	well	ADV
gs-3446	335	47	mimic	mimic	VERB
gs-3446	335	48	physiological	physiological	ADJ
gs-3446	335	49	conditions	condition	NOUN
gs-3446	335	50	(	(	PUNCT
gs-3446	335	51	aphkhazava	aphkhazava	NOUN
gs-3446	335	52	et	et	PROPN
gs-3446	335	53	al	al	PROPN
gs-3446	335	54	.	.	PROPN
gs-3446	335	55	2023	2023	NUM
gs-3446	335	56	)	)	PUNCT
gs-3446	335	57	.	.	PUNCT
gs-3446	336	1	the	the	DET
gs-3446	336	2	analysis	analysis	NOUN
gs-3446	336	3	of	of	ADP
gs-3446	336	4	transcriptional	transcriptional	ADJ
gs-3446	336	5	circuits	circuit	NOUN
gs-3446	336	6	in	in	ADP
gs-3446	336	7	stem	stem	NOUN
gs-3446	336	8	cells	cell	NOUN
gs-3446	336	9	reveals	reveal	VERB
gs-3446	336	10	a	a	DET
gs-3446	336	11	highly	highly	ADV
gs-3446	336	12	dynamic	dynamic	ADJ
gs-3446	336	13	,	,	PUNCT
gs-3446	336	14	context	context	NOUN
gs-3446	336	15	-	-	PUNCT
gs-3446	336	16	dependent	dependent	ADJ
gs-3446	336	17	regulatory	regulatory	ADJ
gs-3446	336	18	system	system	NOUN
gs-3446	336	19	that	that	PRON
gs-3446	336	20	governs	govern	VERB
gs-3446	336	21	cell	cell	NOUN
gs-3446	336	22	fate	fate	NOUN
gs-3446	336	23	decisions	decision	NOUN
gs-3446	336	24	.	.	PUNCT
gs-3446	337	1	while	while	SCONJ
gs-3446	337	2	pluripotent	pluripotent	ADJ
gs-3446	337	3	stem	stem	NOUN
gs-3446	337	4	cells	cell	NOUN
gs-3446	337	5	exhibit	exhibit	VERB
gs-3446	337	6	a	a	DET
gs-3446	337	7	fluid	fluid	ADJ
gs-3446	337	8	transcriptional	transcriptional	NOUN
gs-3446	337	9	network	network	NOUN
gs-3446	337	10	allowing	allow	VERB
gs-3446	337	11	lineage	lineage	NOUN
gs-3446	337	12	flexibility	flexibility	NOUN
gs-3446	337	13	,	,	PUNCT
gs-3446	337	14	multipotent	multipotent	NOUN
gs-3446	337	15	and	and	CCONJ
gs-3446	337	16	unipotent	unipotent	ADJ
gs-3446	337	17	cells	cell	NOUN
gs-3446	337	18	demonstrate	demonstrate	VERB
gs-3446	337	19	progressively	progressively	ADV
gs-3446	337	20	tighter	tight	ADJ
gs-3446	337	21	regulatory	regulatory	ADJ
gs-3446	337	22	control	control	NOUN
gs-3446	337	23	.	.	PUNCT
gs-3446	338	1	understanding	understand	VERB
gs-3446	338	2	these	these	DET
gs-3446	338	3	circuits	circuit	NOUN
gs-3446	338	4	not	not	PART
gs-3446	338	5	only	only	ADV
gs-3446	338	6	advances	advance	VERB
gs-3446	338	7	fundamental	fundamental	ADJ
gs-3446	338	8	biology	biology	NOUN
gs-3446	338	9	but	but	CCONJ
gs-3446	338	10	also	also	ADV
gs-3446	338	11	holds	hold	VERB
gs-3446	338	12	key	key	ADJ
gs-3446	338	13	translational	translational	ADJ
gs-3446	338	14	potential	potential	NOUN
gs-3446	338	15	for	for	ADP
gs-3446	338	16	regenerative	regenerative	ADJ
gs-3446	338	17	medicine	medicine	NOUN
gs-3446	338	18	,	,	PUNCT
gs-3446	338	19	disease	disease	NOUN
gs-3446	338	20	modeling	modeling	NOUN
gs-3446	338	21	,	,	PUNCT
gs-3446	338	22	and	and	CCONJ
gs-3446	338	23	cancer	cancer	NOUN
gs-3446	338	24	therapy	therapy	NOUN
gs-3446	338	25	.	.	PUNCT
gs-3446	339	1	future	future	ADJ
gs-3446	339	2	research	research	NOUN
gs-3446	339	3	should	should	AUX
gs-3446	339	4	focus	focus	VERB
gs-3446	339	5	on	on	ADP
gs-3446	339	6	refining	refine	VERB
gs-3446	339	7	transcriptional	transcriptional	ADJ
gs-3446	339	8	control	control	NOUN
gs-3446	339	9	strategies	strategy	NOUN
gs-3446	339	10	to	to	PART
gs-3446	339	11	enhance	enhance	VERB
gs-3446	339	12	differentiation	differentiation	NOUN
gs-3446	339	13	efficiency	efficiency	NOUN
gs-3446	339	14	and	and	CCONJ
gs-3446	339	15	cell	cell	NOUN
gs-3446	339	16	fate	fate	NOUN
gs-3446	339	17	stability	stability	NOUN
gs-3446	339	18	,	,	PUNCT
gs-3446	339	19	bridging	bridge	VERB
gs-3446	339	20	the	the	DET
gs-3446	339	21	gap	gap	NOUN
gs-3446	339	22	between	between	ADP
gs-3446	339	23	stem	stem	NOUN
gs-3446	339	24	cell	cell	NOUN
gs-3446	339	25	research	research	NOUN
gs-3446	339	26	and	and	CCONJ
gs-3446	339	27	clinical	clinical	ADJ
gs-3446	339	28	application	application	NOUN
gs-3446	339	29	.	.	PUNCT
gs-3446	340	1	summary	summary	NOUN
gs-3446	340	2	of	of	ADP
gs-3446	340	3	transcriptional	transcriptional	ADJ
gs-3446	340	4	circuits	circuit	NOUN
gs-3446	340	5	in	in	ADP
gs-3446	340	6	stem	stem	NOUN
gs-3446	340	7	cell	cell	NOUN
gs-3446	340	8	heterogeneity	heterogeneity	NOUN
gs-3446	340	9	stem	stem	NOUN
gs-3446	340	10	cells	cell	NOUN
gs-3446	340	11	exhibit	exhibit	VERB
gs-3446	340	12	varying	vary	VERB
gs-3446	340	13	degrees	degree	NOUN
gs-3446	340	14	of	of	ADP
gs-3446	340	15	differentiation	differentiation	NOUN
gs-3446	340	16	potential	potential	NOUN
gs-3446	340	17	,	,	PUNCT
gs-3446	340	18	from	from	ADP
gs-3446	340	19	pluripotency	pluripotency	NOUN
gs-3446	340	20	(	(	PUNCT
gs-3446	340	21	capable	capable	ADJ
gs-3446	340	22	of	of	ADP
gs-3446	340	23	generating	generate	VERB
gs-3446	340	24	all	all	DET
gs-3446	340	25	embryonic	embryonic	ADJ
gs-3446	340	26	lineages	lineage	NOUN
gs-3446	340	27	)	)	PUNCT
gs-3446	340	28	to	to	PART
gs-3446	340	29	multipotency	multipotency	VERB
gs-3446	340	30	(	(	PUNCT
gs-3446	340	31	restricted	restrict	VERB
gs-3446	340	32	to	to	ADP
gs-3446	340	33	specific	specific	ADJ
gs-3446	340	34	lineages	lineage	NOUN
gs-3446	340	35	)	)	PUNCT
gs-3446	340	36	and	and	CCONJ
gs-3446	340	37	unipotency	unipotency	NOUN
gs-3446	340	38	(	(	PUNCT
gs-3446	340	39	committed	commit	VERB
gs-3446	340	40	to	to	ADP
gs-3446	340	41	a	a	DET
gs-3446	340	42	single	single	ADJ
gs-3446	340	43	fate	fate	NOUN
gs-3446	340	44	)	)	PUNCT
gs-3446	340	45	.	.	PUNCT
gs-3446	341	1	this	this	DET
gs-3446	341	2	heterogeneity	heterogeneity	NOUN
gs-3446	341	3	is	be	AUX
gs-3446	341	4	regulated	regulate	VERB
gs-3446	341	5	by	by	ADP
gs-3446	341	6	dynamic	dynamic	ADJ
gs-3446	341	7	transcriptional	transcriptional	ADJ
gs-3446	341	8	circuits	circuit	NOUN
gs-3446	341	9	,	,	PUNCT
gs-3446	341	10	which	which	PRON
gs-3446	341	11	govern	govern	VERB
gs-3446	341	12	selfrenewal	selfrenewal	NOUN
gs-3446	341	13	,	,	PUNCT
gs-3446	341	14	lineage	lineage	NOUN
gs-3446	341	15	commitment	commitment	NOUN
gs-3446	341	16	,	,	PUNCT
gs-3446	341	17	and	and	CCONJ
gs-3446	341	18	plasticity	plasticity	NOUN
gs-3446	341	19	.	.	PUNCT
gs-3446	342	1	1	1	X
gs-3446	342	2	.	.	X
gs-3446	342	3	pluripotency	pluripotency	NOUN
gs-3446	342	4	:	:	PUNCT
gs-3446	342	5	pluripotent	pluripotent	ADJ
gs-3446	342	6	stem	stem	NOUN
gs-3446	342	7	cells	cell	NOUN
gs-3446	342	8	(	(	PUNCT
gs-3446	342	9	e.g.	e.g.	ADV
gs-3446	342	10	,	,	PUNCT
gs-3446	342	11	escs	esc	NOUN
gs-3446	342	12	,	,	PUNCT
gs-3446	342	13	ipscs	ipsc	NOUN
gs-3446	342	14	)	)	PUNCT
gs-3446	342	15	are	be	AUX
gs-3446	342	16	controlled	control	VERB
gs-3446	342	17	by	by	ADP
gs-3446	342	18	a	a	DET
gs-3446	342	19	core	core	ADJ
gs-3446	342	20	transcriptional	transcriptional	ADJ
gs-3446	342	21	network	network	NOUN
gs-3446	342	22	—	—	PUNCT
gs-3446	342	23	oct4	oct4	NOUN
gs-3446	342	24	,	,	PUNCT
gs-3446	342	25	sox2	sox2	NOUN
gs-3446	342	26	,	,	PUNCT
gs-3446	342	27	and	and	CCONJ
gs-3446	342	28	nanog	nanog	PROPN
gs-3446	342	29	—	—	PUNCT
gs-3446	342	30	that	that	PRON
gs-3446	342	31	maintains	maintain	VERB
gs-3446	342	32	self	self	NOUN
gs-3446	342	33	-	-	PUNCT
gs-3446	342	34	renewal	renewal	NOUN
gs-3446	342	35	while	while	SCONJ
gs-3446	342	36	repressing	repress	VERB
gs-3446	342	37	differentiation	differentiation	NOUN
gs-3446	342	38	.	.	PUNCT
gs-3446	343	1	however	however	ADV
gs-3446	343	2	,	,	PUNCT
gs-3446	343	3	heterogeneity	heterogeneity	NOUN
gs-3446	343	4	within	within	ADP
gs-3446	343	5	pluripotent	pluripotent	ADJ
gs-3446	343	6	populations	population	NOUN
gs-3446	343	7	arises	arise	VERB
gs-3446	343	8	due	due	ADJ
gs-3446	343	9	to	to	ADP
gs-3446	343	10	fluctuations	fluctuation	NOUN
gs-3446	343	11	in	in	ADP
gs-3446	343	12	lineage	lineage	NOUN
gs-3446	343	13	-	-	PUNCT
gs-3446	343	14	associated	associate	VERB
gs-3446	343	15	genes	gene	NOUN
gs-3446	343	16	,	,	PUNCT
gs-3446	343	17	making	make	VERB
gs-3446	343	18	them	they	PRON
gs-3446	343	19	primed	prime	VERB
gs-3446	343	20	for	for	ADP
gs-3446	343	21	differentiation	differentiation	NOUN
gs-3446	343	22	.	.	PUNCT
gs-3446	344	1	georgian	georgian	ADJ
gs-3446	344	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	344	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	344	4	ტ.	ტ.	VERB
gs-3446	344	5	7	7	NUM
gs-3446	344	6	n	n	DET
gs-3446	344	7	1	1	NUM
gs-3446	344	8	,	,	PUNCT
gs-3446	344	9	2025	2025	NUM
gs-3446	344	10	292	292	NUM
gs-3446	344	11	2	2	NUM
gs-3446	344	12	.	.	X
gs-3446	344	13	multipotency	multipotency	NOUN
gs-3446	344	14	:	:	PUNCT
gs-3446	344	15	in	in	ADP
gs-3446	344	16	multipotent	multipotent	NOUN
gs-3446	344	17	stem	stem	NOUN
gs-3446	344	18	cells	cell	NOUN
gs-3446	344	19	(	(	PUNCT
gs-3446	344	20	e.g.	e.g.	ADV
gs-3446	344	21	,	,	PUNCT
gs-3446	344	22	hematopoietic	hematopoietic	ADJ
gs-3446	344	23	,	,	PUNCT
gs-3446	344	24	neural	neural	ADJ
gs-3446	344	25	,	,	PUNCT
gs-3446	344	26	mesenchymal	mesenchymal	ADJ
gs-3446	344	27	stem	stem	NOUN
gs-3446	344	28	cells	cell	NOUN
gs-3446	344	29	)	)	PUNCT
gs-3446	344	30	,	,	PUNCT
gs-3446	344	31	transcription	transcription	NOUN
gs-3446	344	32	factors	factor	NOUN
gs-3446	344	33	like	like	ADP
gs-3446	344	34	runx1	runx1	PROPN
gs-3446	344	35	,	,	PUNCT
gs-3446	344	36	sox9	sox9	PROPN
gs-3446	344	37	,	,	PUNCT
gs-3446	344	38	and	and	CCONJ
gs-3446	344	39	pax7	pax7	PROPN
gs-3446	344	40	restrict	restrict	VERB
gs-3446	344	41	fate	fate	NOUN
gs-3446	344	42	options	option	NOUN
gs-3446	344	43	while	while	SCONJ
gs-3446	344	44	preserving	preserve	VERB
gs-3446	344	45	some	some	DET
gs-3446	344	46	degree	degree	NOUN
gs-3446	344	47	of	of	ADP
gs-3446	344	48	plasticity	plasticity	NOUN
gs-3446	344	49	.	.	PUNCT
gs-3446	345	1	progressive	progressive	ADJ
gs-3446	345	2	chromatin	chromatin	NOUN
gs-3446	345	3	remodeling	remodeling	NOUN
gs-3446	345	4	further	far	ADV
gs-3446	345	5	reinforces	reinforce	VERB
gs-3446	345	6	lineage	lineage	NOUN
gs-3446	345	7	commitment	commitment	NOUN
gs-3446	345	8	,	,	PUNCT
gs-3446	345	9	demonstrating	demonstrate	VERB
gs-3446	345	10	that	that	DET
gs-3446	345	11	differentiation	differentiation	NOUN
gs-3446	345	12	is	be	AUX
gs-3446	345	13	a	a	DET
gs-3446	345	14	gradual	gradual	ADJ
gs-3446	345	15	process	process	NOUN
gs-3446	345	16	rather	rather	ADV
gs-3446	345	17	than	than	ADP
gs-3446	345	18	a	a	DET
gs-3446	345	19	binary	binary	ADJ
gs-3446	345	20	switch	switch	NOUN
gs-3446	345	21	.	.	PUNCT
gs-3446	346	1	3	3	X
gs-3446	346	2	.	.	X
gs-3446	346	3	unipotency	unipotency	NOUN
gs-3446	346	4	:	:	PUNCT
gs-3446	346	5	unipotent	unipotent	ADJ
gs-3446	346	6	stem	stem	NOUN
gs-3446	346	7	cells	cell	NOUN
gs-3446	346	8	(	(	PUNCT
gs-3446	346	9	e.g.	e.g.	ADV
gs-3446	346	10	,	,	PUNCT
gs-3446	346	11	muscle	muscle	NOUN
gs-3446	346	12	satellite	satellite	NOUN
gs-3446	346	13	cells	cell	NOUN
gs-3446	346	14	,	,	PUNCT
gs-3446	346	15	epidermal	epidermal	ADJ
gs-3446	346	16	stem	stem	NOUN
gs-3446	346	17	cells	cell	NOUN
gs-3446	346	18	)	)	PUNCT
gs-3446	346	19	exhibit	exhibit	VERB
gs-3446	346	20	tightly	tightly	ADV
gs-3446	346	21	regulated	regulated	ADJ
gs-3446	346	22	transcriptional	transcriptional	ADJ
gs-3446	346	23	programs	program	NOUN
gs-3446	346	24	(	(	PUNCT
gs-3446	346	25	e.g.	e.g.	ADV
gs-3446	346	26	,	,	PUNCT
gs-3446	346	27	myod1	myod1	NOUN
gs-3446	346	28	in	in	ADP
gs-3446	346	29	muscle	muscle	NOUN
gs-3446	346	30	,	,	PUNCT
gs-3446	346	31	tp63	tp63	PROPN
gs-3446	346	32	in	in	ADP
gs-3446	346	33	epidermis	epidermis	NOUN
gs-3446	346	34	)	)	PUNCT
gs-3446	346	35	that	that	PRON
gs-3446	346	36	enforce	enforce	VERB
gs-3446	346	37	lineage	lineage	NOUN
gs-3446	346	38	stability	stability	NOUN
gs-3446	346	39	.	.	PUNCT
gs-3446	347	1	however	however	ADV
gs-3446	347	2	,	,	PUNCT
gs-3446	347	3	under	under	ADP
gs-3446	347	4	certain	certain	ADJ
gs-3446	347	5	conditions	condition	NOUN
gs-3446	347	6	,	,	PUNCT
gs-3446	347	7	such	such	ADJ
gs-3446	347	8	as	as	ADP
gs-3446	347	9	injury	injury	NOUN
gs-3446	347	10	or	or	CCONJ
gs-3446	347	11	reprogramming	reprogramme	VERB
gs-3446	347	12	signals	signal	NOUN
gs-3446	347	13	,	,	PUNCT
gs-3446	347	14	some	some	DET
gs-3446	347	15	unipotent	unipotent	ADJ
gs-3446	347	16	cells	cell	NOUN
gs-3446	347	17	may	may	AUX
gs-3446	347	18	regain	regain	VERB
gs-3446	347	19	plasticity	plasticity	NOUN
gs-3446	347	20	,	,	PUNCT
gs-3446	347	21	suggesting	suggest	VERB
gs-3446	347	22	potential	potential	NOUN
gs-3446	347	23	for	for	ADP
gs-3446	347	24	regenerative	regenerative	ADJ
gs-3446	347	25	applications	application	NOUN
gs-3446	347	26	(	(	PUNCT
gs-3446	347	27	aphkhazava	aphkhazava	NOUN
gs-3446	347	28	et	et	PROPN
gs-3446	347	29	al	al	PROPN
gs-3446	347	30	.	.	PROPN
gs-3446	347	31	2023	2023	NUM
gs-3446	347	32	)	)	PUNCT
gs-3446	347	33	.	.	PUNCT
gs-3446	348	1	4	4	X
gs-3446	348	2	.	.	X
gs-3446	348	3	disease	disease	NOUN
gs-3446	348	4	and	and	CCONJ
gs-3446	348	5	therapeutic	therapeutic	ADJ
gs-3446	348	6	implications	implication	NOUN
gs-3446	348	7	:	:	PUNCT
gs-3446	348	8	dysregulation	dysregulation	NOUN
gs-3446	348	9	of	of	ADP
gs-3446	348	10	transcriptional	transcriptional	ADJ
gs-3446	348	11	circuits	circuit	NOUN
gs-3446	348	12	can	can	AUX
gs-3446	348	13	lead	lead	VERB
gs-3446	348	14	to	to	ADP
gs-3446	348	15	disease	disease	NOUN
gs-3446	348	16	,	,	PUNCT
gs-3446	348	17	including	include	VERB
gs-3446	348	18	cancer	cancer	NOUN
gs-3446	348	19	,	,	PUNCT
gs-3446	348	20	where	where	SCONJ
gs-3446	348	21	stem	stem	NOUN
gs-3446	348	22	-	-	PUNCT
gs-3446	348	23	like	like	ADJ
gs-3446	348	24	properties	property	NOUN
gs-3446	348	25	are	be	AUX
gs-3446	348	26	hijacked	hijack	VERB
gs-3446	348	27	to	to	PART
gs-3446	348	28	promote	promote	VERB
gs-3446	348	29	tumor	tumor	NOUN
gs-3446	348	30	growth	growth	NOUN
gs-3446	348	31	(	(	PUNCT
gs-3446	348	32	e.g.	e.g.	ADV
gs-3446	348	33	,	,	PUNCT
gs-3446	348	34	sox2	sox2	NOUN
gs-3446	348	35	in	in	ADP
gs-3446	348	36	glioblastoma	glioblastoma	NOUN
gs-3446	348	37	,	,	PUNCT
gs-3446	348	38	myc	myc	PROPN
gs-3446	348	39	in	in	ADP
gs-3446	348	40	leukemia	leukemia	NOUN
gs-3446	348	41	)	)	PUNCT
gs-3446	348	42	.	.	PUNCT
gs-3446	349	1	understanding	understand	VERB
gs-3446	349	2	these	these	DET
gs-3446	349	3	networks	network	NOUN
gs-3446	349	4	is	be	AUX
gs-3446	349	5	essential	essential	ADJ
gs-3446	349	6	for	for	ADP
gs-3446	349	7	designing	design	VERB
gs-3446	349	8	targeted	target	VERB
gs-3446	349	9	therapies	therapy	NOUN
gs-3446	349	10	.	.	PUNCT
gs-3446	350	1	in	in	ADP
gs-3446	350	2	regenerative	regenerative	ADJ
gs-3446	350	3	medicine	medicine	NOUN
gs-3446	350	4	,	,	PUNCT
gs-3446	350	5	modulating	modulate	VERB
gs-3446	350	6	transcription	transcription	NOUN
gs-3446	350	7	factors	factor	NOUN
gs-3446	350	8	can	can	AUX
gs-3446	350	9	improve	improve	VERB
gs-3446	350	10	directed	directed	ADJ
gs-3446	350	11	differentiation	differentiation	NOUN
gs-3446	350	12	,	,	PUNCT
gs-3446	350	13	enhancing	enhance	VERB
gs-3446	350	14	the	the	DET
gs-3446	350	15	effectiveness	effectiveness	NOUN
gs-3446	350	16	of	of	ADP
gs-3446	350	17	stem	stem	NOUN
gs-3446	350	18	cell	cell	NOUN
gs-3446	350	19	-	-	PUNCT
gs-3446	350	20	based	base	VERB
gs-3446	350	21	treatments	treatment	NOUN
gs-3446	350	22	(	(	PUNCT
gs-3446	350	23	aphkhazava	aphkhazava	NOUN
gs-3446	350	24	et	et	PROPN
gs-3446	350	25	al	al	PROPN
gs-3446	350	26	.	.	PROPN
gs-3446	350	27	2024	2024	NUM
gs-3446	350	28	)	)	PUNCT
gs-3446	350	29	.	.	PUNCT
gs-3446	351	1	5	5	X
gs-3446	351	2	.	.	X
gs-3446	351	3	future	future	ADJ
gs-3446	351	4	directions	direction	NOUN
gs-3446	351	5	:	:	PUNCT
gs-3446	351	6	advances	advance	NOUN
gs-3446	351	7	in	in	ADP
gs-3446	351	8	single	single	ADJ
gs-3446	351	9	-	-	PUNCT
gs-3446	351	10	cell	cell	NOUN
gs-3446	351	11	omics	omic	NOUN
gs-3446	351	12	,	,	PUNCT
gs-3446	351	13	epigenetics	epigenetic	NOUN
gs-3446	351	14	,	,	PUNCT
gs-3446	351	15	and	and	CCONJ
gs-3446	351	16	chromatin	chromatin	NOUN
gs-3446	351	17	remodeling	remodeling	NOUN
gs-3446	351	18	provide	provide	VERB
gs-3446	351	19	new	new	ADJ
gs-3446	351	20	insights	insight	NOUN
gs-3446	351	21	into	into	ADP
gs-3446	351	22	transcriptional	transcriptional	ADJ
gs-3446	351	23	heterogeneity	heterogeneity	NOUN
gs-3446	351	24	.	.	PUNCT
gs-3446	352	1	future	future	ADJ
gs-3446	352	2	research	research	NOUN
gs-3446	352	3	should	should	AUX
gs-3446	352	4	focus	focus	VERB
gs-3446	352	5	on	on	ADP
gs-3446	352	6	refining	refine	VERB
gs-3446	352	7	transcriptional	transcriptional	ADJ
gs-3446	352	8	engineering	engineering	NOUN
gs-3446	352	9	approaches	approach	NOUN
gs-3446	352	10	,	,	PUNCT
gs-3446	352	11	improving	improve	VERB
gs-3446	352	12	differentiation	differentiation	NOUN
gs-3446	352	13	efficiency	efficiency	NOUN
gs-3446	352	14	,	,	PUNCT
gs-3446	352	15	and	and	CCONJ
gs-3446	352	16	bridging	bridge	VERB
gs-3446	352	17	the	the	DET
gs-3446	352	18	gap	gap	NOUN
gs-3446	352	19	between	between	ADP
gs-3446	352	20	stem	stem	NOUN
gs-3446	352	21	cell	cell	NOUN
gs-3446	352	22	research	research	NOUN
gs-3446	352	23	and	and	CCONJ
gs-3446	352	24	clinical	clinical	ADJ
gs-3446	352	25	applications	application	NOUN
gs-3446	352	26	(	(	PUNCT
gs-3446	352	27	zare	zare	PROPN
gs-3446	352	28	et	et	PROPN
gs-3446	352	29	al	al	PROPN
gs-3446	352	30	.	.	PROPN
gs-3446	352	31	2023	2023	NUM
gs-3446	352	32	)	)	PUNCT
gs-3446	352	33	.	.	PUNCT
gs-3446	353	1	transcriptional	transcriptional	ADJ
gs-3446	353	2	circuits	circuit	NOUN
gs-3446	353	3	underpin	underpin	VERB
gs-3446	353	4	stem	stem	NOUN
gs-3446	353	5	cell	cell	NOUN
gs-3446	353	6	heterogeneity	heterogeneity	NOUN
gs-3446	353	7	,	,	PUNCT
gs-3446	353	8	guiding	guide	VERB
gs-3446	353	9	fate	fate	NOUN
gs-3446	353	10	decisions	decision	NOUN
gs-3446	353	11	at	at	ADP
gs-3446	353	12	different	different	ADJ
gs-3446	353	13	potency	potency	NOUN
gs-3446	353	14	levels	level	NOUN
gs-3446	353	15	.	.	PUNCT
gs-3446	354	1	deciphering	decipher	VERB
gs-3446	354	2	these	these	DET
gs-3446	354	3	regulatory	regulatory	ADJ
gs-3446	354	4	networks	network	NOUN
gs-3446	354	5	is	be	AUX
gs-3446	354	6	crucial	crucial	ADJ
gs-3446	354	7	for	for	ADP
gs-3446	354	8	optimizing	optimize	VERB
gs-3446	354	9	stem	stem	NOUN
gs-3446	354	10	cell	cell	NOUN
gs-3446	354	11	therapies	therapy	NOUN
gs-3446	354	12	,	,	PUNCT
gs-3446	354	13	regenerative	regenerative	ADJ
gs-3446	354	14	medicine	medicine	NOUN
gs-3446	354	15	,	,	PUNCT
gs-3446	354	16	and	and	CCONJ
gs-3446	354	17	cancer	cancer	NOUN
gs-3446	354	18	treatment	treatment	NOUN
gs-3446	354	19	.	.	PUNCT
gs-3446	355	1	by	by	ADP
gs-3446	355	2	controlling	control	VERB
gs-3446	355	3	transcriptional	transcriptional	ADJ
gs-3446	355	4	circuits	circuit	NOUN
gs-3446	355	5	,	,	PUNCT
gs-3446	355	6	we	we	PRON
gs-3446	355	7	can	can	AUX
gs-3446	355	8	harness	harness	NOUN
gs-3446	355	9	stem	stem	NOUN
gs-3446	355	10	cells	cell	NOUN
gs-3446	355	11	more	more	ADV
gs-3446	355	12	effectively	effectively	ADV
gs-3446	355	13	for	for	ADP
gs-3446	355	14	biomedical	biomedical	ADJ
gs-3446	355	15	applications	application	NOUN
gs-3446	355	16	.	.	PUNCT
gs-3446	356	1	stem	stem	NOUN
gs-3446	356	2	cell	cell	NOUN
gs-3446	356	3	heterogeneity	heterogeneity	NOUN
gs-3446	356	4	is	be	AUX
gs-3446	356	5	governed	govern	VERB
gs-3446	356	6	by	by	ADP
gs-3446	356	7	intricate	intricate	ADJ
gs-3446	356	8	transcriptional	transcriptional	ADJ
gs-3446	356	9	circuits	circuit	NOUN
gs-3446	356	10	that	that	PRON
gs-3446	356	11	regulate	regulate	VERB
gs-3446	356	12	self	self	NOUN
gs-3446	356	13	-	-	PUNCT
gs-3446	356	14	renewal	renewal	NOUN
gs-3446	356	15	,	,	PUNCT
gs-3446	356	16	plasticity	plasticity	NOUN
gs-3446	356	17	,	,	PUNCT
gs-3446	356	18	and	and	CCONJ
gs-3446	356	19	lineage	lineage	NOUN
gs-3446	356	20	commitment	commitment	NOUN
gs-3446	356	21	across	across	ADP
gs-3446	356	22	different	different	ADJ
gs-3446	356	23	potency	potency	NOUN
gs-3446	356	24	states	state	NOUN
gs-3446	356	25	.	.	PUNCT
gs-3446	357	1	in	in	ADP
gs-3446	357	2	pluripotent	pluripotent	ADJ
gs-3446	357	3	stem	stem	NOUN
gs-3446	357	4	cells	cell	NOUN
gs-3446	357	5	,	,	PUNCT
gs-3446	357	6	core	core	NOUN
gs-3446	357	7	transcription	transcription	NOUN
gs-3446	357	8	factors	factor	NOUN
gs-3446	357	9	(	(	PUNCT
gs-3446	357	10	oct4	oct4	NOUN
gs-3446	357	11	,	,	PUNCT
gs-3446	357	12	sox2	sox2	NOUN
gs-3446	357	13	,	,	PUNCT
gs-3446	357	14	nanog	nanog	PROPN
gs-3446	357	15	)	)	PUNCT
gs-3446	357	16	maintain	maintain	VERB
gs-3446	357	17	an	an	DET
gs-3446	357	18	undifferentiated	undifferentiated	ADJ
gs-3446	357	19	state	state	NOUN
gs-3446	357	20	while	while	SCONJ
gs-3446	357	21	permitting	permit	VERB
gs-3446	357	22	dynamic	dynamic	ADJ
gs-3446	357	23	fluctuations	fluctuation	NOUN
gs-3446	357	24	that	that	SCONJ
gs-3446	357	25	prime	prime	ADJ
gs-3446	357	26	cells	cell	NOUN
gs-3446	357	27	for	for	ADP
gs-3446	357	28	differentiation	differentiation	NOUN
gs-3446	357	29	.	.	PUNCT
gs-3446	358	1	as	as	SCONJ
gs-3446	358	2	cells	cell	NOUN
gs-3446	358	3	transition	transition	VERB
gs-3446	358	4	to	to	PART
gs-3446	358	5	multipotency	multipotency	VERB
gs-3446	358	6	,	,	PUNCT
gs-3446	358	7	lineagerestricting	lineagerestricte	VERB
gs-3446	358	8	regulators	regulator	NOUN
gs-3446	358	9	(	(	PUNCT
gs-3446	358	10	e.g.	e.g.	ADV
gs-3446	358	11	,	,	PUNCT
gs-3446	358	12	runx1	runx1	NOUN
gs-3446	358	13	in	in	ADP
gs-3446	358	14	hematopoiesis	hematopoiesis	NOUN
gs-3446	358	15	,	,	PUNCT
gs-3446	358	16	sox9	sox9	PROPN
gs-3446	358	17	in	in	ADP
gs-3446	358	18	neural	neural	ADJ
gs-3446	358	19	crest	crest	NOUN
gs-3446	358	20	cells	cell	NOUN
gs-3446	358	21	)	)	PUNCT
gs-3446	358	22	progressively	progressively	ADV
gs-3446	358	23	shape	shape	VERB
gs-3446	358	24	fate	fate	NOUN
gs-3446	358	25	decisions	decision	NOUN
gs-3446	358	26	,	,	PUNCT
gs-3446	358	27	balancing	balance	VERB
gs-3446	358	28	flexibility	flexibility	NOUN
gs-3446	358	29	and	and	CCONJ
gs-3446	358	30	commitment	commitment	NOUN
gs-3446	358	31	.	.	PUNCT
gs-3446	359	1	unipotent	unipotent	ADJ
gs-3446	359	2	stem	stem	NOUN
gs-3446	359	3	cells	cell	NOUN
gs-3446	359	4	,	,	PUNCT
gs-3446	359	5	while	while	SCONJ
gs-3446	359	6	highly	highly	ADV
gs-3446	359	7	specialized	specialized	ADJ
gs-3446	359	8	,	,	PUNCT
gs-3446	359	9	retain	retain	VERB
gs-3446	359	10	latent	latent	NOUN
gs-3446	359	11	plasticity	plasticity	NOUN
gs-3446	359	12	under	under	ADP
gs-3446	359	13	specific	specific	ADJ
gs-3446	359	14	conditions	condition	NOUN
gs-3446	359	15	,	,	PUNCT
gs-3446	359	16	challenging	challenge	VERB
gs-3446	359	17	the	the	DET
gs-3446	359	18	notion	notion	NOUN
gs-3446	359	19	of	of	ADP
gs-3446	359	20	irreversible	irreversible	ADJ
gs-3446	359	21	differentiation	differentiation	NOUN
gs-3446	359	22	.	.	PUNCT
gs-3446	360	1	understanding	understand	VERB
gs-3446	360	2	these	these	DET
gs-3446	360	3	transcriptional	transcriptional	ADJ
gs-3446	360	4	networks	network	NOUN
gs-3446	360	5	has	have	VERB
gs-3446	360	6	profound	profound	ADJ
gs-3446	360	7	implications	implication	NOUN
gs-3446	360	8	for	for	ADP
gs-3446	360	9	regenerative	regenerative	ADJ
gs-3446	360	10	medicine	medicine	NOUN
gs-3446	360	11	,	,	PUNCT
gs-3446	360	12	disease	disease	NOUN
gs-3446	360	13	modeling	modeling	NOUN
gs-3446	360	14	,	,	PUNCT
gs-3446	360	15	and	and	CCONJ
gs-3446	360	16	cancer	cancer	NOUN
gs-3446	360	17	therapy	therapy	NOUN
gs-3446	360	18	.	.	PUNCT
gs-3446	361	1	by	by	ADP
gs-3446	361	2	manipulating	manipulate	VERB
gs-3446	361	3	transcriptional	transcriptional	ADJ
gs-3446	361	4	circuits	circuit	NOUN
gs-3446	361	5	,	,	PUNCT
gs-3446	361	6	researchers	researcher	NOUN
gs-3446	361	7	can	can	AUX
gs-3446	361	8	enhance	enhance	VERB
gs-3446	361	9	the	the	DET
gs-3446	361	10	efficiency	efficiency	NOUN
gs-3446	361	11	of	of	ADP
gs-3446	361	12	directed	direct	VERB
gs-3446	361	13	differentiation	differentiation	NOUN
gs-3446	361	14	,	,	PUNCT
gs-3446	361	15	improve	improve	VERB
gs-3446	361	16	stem	stem	NOUN
gs-3446	361	17	cell	cell	NOUN
gs-3446	361	18	-	-	PUNCT
gs-3446	361	19	based	base	VERB
gs-3446	361	20	therapies	therapy	NOUN
gs-3446	361	21	,	,	PUNCT
gs-3446	361	22	and	and	CCONJ
gs-3446	361	23	identify	identify	VERB
gs-3446	361	24	novel	novel	ADJ
gs-3446	361	25	strategies	strategy	NOUN
gs-3446	361	26	for	for	ADP
gs-3446	361	27	targeting	target	VERB
gs-3446	361	28	aberrant	aberrant	ADJ
gs-3446	361	29	stem	stem	NOUN
gs-3446	361	30	-	-	PUNCT
gs-3446	361	31	like	like	ADJ
gs-3446	361	32	states	state	NOUN
gs-3446	361	33	in	in	ADP
gs-3446	361	34	cancer	cancer	NOUN
gs-3446	361	35	.	.	PUNCT
gs-3446	362	1	future	future	ADJ
gs-3446	362	2	advancements	advancement	NOUN
gs-3446	362	3	in	in	ADP
gs-3446	362	4	single	single	ADJ
gs-3446	362	5	-	-	PUNCT
gs-3446	362	6	cell	cell	NOUN
gs-3446	362	7	technologies	technology	NOUN
gs-3446	362	8	,	,	PUNCT
gs-3446	362	9	epigenetic	epigenetic	ADJ
gs-3446	362	10	editing	editing	NOUN
gs-3446	362	11	,	,	PUNCT
gs-3446	362	12	and	and	CCONJ
gs-3446	362	13	systems	system	NOUN
gs-3446	362	14	biology	biology	NOUN
gs-3446	362	15	will	will	AUX
gs-3446	362	16	further	far	ADV
gs-3446	362	17	refine	refine	VERB
gs-3446	362	18	our	our	PRON
gs-3446	362	19	ability	ability	NOUN
gs-3446	362	20	to	to	PART
gs-3446	362	21	control	control	VERB
gs-3446	362	22	stem	stem	NOUN
gs-3446	362	23	cell	cell	NOUN
gs-3446	362	24	fate	fate	NOUN
gs-3446	362	25	,	,	PUNCT
gs-3446	362	26	unlocking	unlock	VERB
gs-3446	362	27	new	new	ADJ
gs-3446	362	28	possibilities	possibility	NOUN
gs-3446	362	29	for	for	ADP
gs-3446	362	30	therapeutic	therapeutic	ADJ
gs-3446	362	31	interventions	intervention	NOUN
gs-3446	362	32	(	(	PUNCT
gs-3446	362	33	zare	zare	PROPN
gs-3446	362	34	et	et	PROPN
gs-3446	362	35	al	al	PROPN
gs-3446	362	36	.	.	PROPN
gs-3446	362	37	2023	2023	NUM
gs-3446	362	38	)	)	PUNCT
gs-3446	362	39	.	.	PUNCT
gs-3446	363	1	georgian	georgian	ADJ
gs-3446	363	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	363	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	363	4	ტ.	ტ.	VERB
gs-3446	363	5	7	7	NUM
gs-3446	363	6	n	n	PRON
gs-3446	363	7	1	1	NUM
gs-3446	363	8	,	,	PUNCT
gs-3446	363	9	2025	2025	NUM
gs-3446	363	10	293	293	NUM
gs-3446	363	11	based	base	VERB
gs-3446	363	12	on	on	ADP
gs-3446	363	13	the	the	DET
gs-3446	363	14	analysis	analysis	NOUN
gs-3446	363	15	of	of	ADP
gs-3446	363	16	transcriptional	transcriptional	ADJ
gs-3446	363	17	circuits	circuit	NOUN
gs-3446	363	18	in	in	ADP
gs-3446	363	19	stem	stem	NOUN
gs-3446	363	20	cell	cell	NOUN
gs-3446	363	21	heterogeneity	heterogeneity	NOUN
gs-3446	363	22	,	,	PUNCT
gs-3446	363	23	the	the	DET
gs-3446	363	24	following	follow	VERB
gs-3446	363	25	recommendations	recommendation	NOUN
gs-3446	363	26	can	can	AUX
gs-3446	363	27	enhance	enhance	VERB
gs-3446	363	28	research	research	NOUN
gs-3446	363	29	,	,	PUNCT
gs-3446	363	30	clinical	clinical	ADJ
gs-3446	363	31	applications	application	NOUN
gs-3446	363	32	,	,	PUNCT
gs-3446	363	33	and	and	CCONJ
gs-3446	363	34	therapeutic	therapeutic	ADJ
gs-3446	363	35	strategies	strategy	NOUN
gs-3446	363	36	:	:	PUNCT
gs-3446	363	37	advance	advance	VERB
gs-3446	363	38	single	single	ADJ
gs-3446	363	39	-	-	PUNCT
gs-3446	363	40	cell	cell	NOUN
gs-3446	363	41	and	and	CCONJ
gs-3446	363	42	multi	multi	ADJ
gs-3446	363	43	-	-	ADJ
gs-3446	363	44	omics	omics	ADJ
gs-3446	363	45	technologies	technology	NOUN
gs-3446	363	46	●	●	PUNCT
gs-3446	363	47	utilize	utilize	VERB
gs-3446	363	48	single	single	ADJ
gs-3446	363	49	-	-	PUNCT
gs-3446	363	50	cell	cell	NOUN
gs-3446	363	51	rna	rna	NOUN
gs-3446	363	52	sequencing	sequence	VERB
gs-3446	363	53	(	(	PUNCT
gs-3446	363	54	scrna	scrna	NOUN
gs-3446	363	55	-	-	PUNCT
gs-3446	363	56	seq	seq	NOUN
gs-3446	363	57	)	)	PUNCT
gs-3446	363	58	,	,	PUNCT
gs-3446	363	59	atac	atac	NOUN
gs-3446	363	60	-	-	PUNCT
gs-3446	363	61	seq	seq	NOUN
gs-3446	363	62	,	,	PUNCT
gs-3446	363	63	and	and	CCONJ
gs-3446	363	64	spatial	spatial	ADJ
gs-3446	363	65	transcriptomics	transcriptomic	NOUN
gs-3446	363	66	to	to	PART
gs-3446	363	67	further	far	ADV
gs-3446	363	68	dissect	dissect	VERB
gs-3446	363	69	transcriptional	transcriptional	ADJ
gs-3446	363	70	heterogeneity	heterogeneity	NOUN
gs-3446	363	71	in	in	ADP
gs-3446	363	72	stem	stem	NOUN
gs-3446	363	73	cell	cell	NOUN
gs-3446	363	74	populations	population	NOUN
gs-3446	363	75	.	.	PUNCT
gs-3446	364	1	●	●	PUNCT
gs-3446	364	2	integrate	integrate	VERB
gs-3446	364	3	multi	multi	ADJ
gs-3446	364	4	-	-	ADJ
gs-3446	364	5	omics	omics	ADJ
gs-3446	364	6	approaches	approach	NOUN
gs-3446	364	7	to	to	PART
gs-3446	364	8	understand	understand	VERB
gs-3446	364	9	how	how	SCONJ
gs-3446	364	10	transcription	transcription	NOUN
gs-3446	364	11	factors	factor	NOUN
gs-3446	364	12	,	,	PUNCT
gs-3446	364	13	epigenetics	epigenetic	NOUN
gs-3446	364	14	,	,	PUNCT
gs-3446	364	15	and	and	CCONJ
gs-3446	364	16	chromatin	chromatin	NOUN
gs-3446	364	17	architecture	architecture	NOUN
gs-3446	364	18	interact	interact	VERB
gs-3446	364	19	to	to	PART
gs-3446	364	20	regulate	regulate	VERB
gs-3446	364	21	cell	cell	NOUN
gs-3446	364	22	fate	fate	NOUN
gs-3446	364	23	decisions	decision	NOUN
gs-3446	364	24	(	(	PUNCT
gs-3446	364	25	zare	zare	PROPN
gs-3446	364	26	et	et	PROPN
gs-3446	364	27	al	al	PROPN
gs-3446	364	28	.	.	PROPN
gs-3446	364	29	2023	2023	NUM
gs-3446	364	30	)	)	PUNCT
gs-3446	364	31	.	.	PUNCT
gs-3446	365	1	improve	improve	VERB
gs-3446	365	2	directed	direct	VERB
gs-3446	365	3	differentiation	differentiation	NOUN
gs-3446	365	4	and	and	CCONJ
gs-3446	365	5	cell	cell	NOUN
gs-3446	365	6	fate	fate	NOUN
gs-3446	365	7	engineering	engineer	VERB
gs-3446	365	8	●	●	PUNCT
gs-3446	365	9	develop	develop	VERB
gs-3446	365	10	optimized	optimize	VERB
gs-3446	365	11	protocols	protocol	NOUN
gs-3446	365	12	that	that	PRON
gs-3446	365	13	modulate	modulate	VERB
gs-3446	365	14	transcription	transcription	NOUN
gs-3446	365	15	factors	factor	NOUN
gs-3446	365	16	and	and	CCONJ
gs-3446	365	17	epigenetic	epigenetic	ADJ
gs-3446	365	18	regulators	regulator	NOUN
gs-3446	365	19	to	to	PART
gs-3446	365	20	enhance	enhance	VERB
gs-3446	365	21	the	the	DET
gs-3446	365	22	efficiency	efficiency	NOUN
gs-3446	365	23	and	and	CCONJ
gs-3446	365	24	fidelity	fidelity	NOUN
gs-3446	365	25	of	of	ADP
gs-3446	365	26	stem	stem	NOUN
gs-3446	365	27	cell	cell	NOUN
gs-3446	365	28	differentiation	differentiation	NOUN
gs-3446	365	29	.	.	PUNCT
gs-3446	366	1	●	●	PUNCT
gs-3446	366	2	explore	explore	NOUN
gs-3446	366	3	synthetic	synthetic	ADJ
gs-3446	366	4	biology	biology	NOUN
gs-3446	366	5	approaches	approach	NOUN
gs-3446	366	6	to	to	PART
gs-3446	366	7	design	design	VERB
gs-3446	366	8	regulatory	regulatory	ADJ
gs-3446	366	9	circuits	circuit	NOUN
gs-3446	366	10	that	that	PRON
gs-3446	366	11	provide	provide	VERB
gs-3446	366	12	precise	precise	ADJ
gs-3446	366	13	control	control	NOUN
gs-3446	366	14	over	over	ADP
gs-3446	366	15	lineage	lineage	NOUN
gs-3446	366	16	commitment	commitment	NOUN
gs-3446	366	17	.	.	PUNCT
gs-3446	367	1	enhance	enhance	VERB
gs-3446	367	2	stem	stem	NOUN
gs-3446	367	3	cell	cell	NOUN
gs-3446	367	4	-	-	PUNCT
gs-3446	367	5	based	base	VERB
gs-3446	367	6	therapeutics	therapeutic	NOUN
gs-3446	367	7	●	●	PUNCT
gs-3446	367	8	apply	apply	VERB
gs-3446	367	9	transcriptional	transcriptional	ADJ
gs-3446	367	10	circuit	circuit	NOUN
gs-3446	367	11	knowledge	knowledge	NOUN
gs-3446	367	12	to	to	PART
gs-3446	367	13	generate	generate	VERB
gs-3446	367	14	stable	stable	ADJ
gs-3446	367	15	,	,	PUNCT
gs-3446	367	16	functional	functional	ADJ
gs-3446	367	17	cell	cell	NOUN
gs-3446	367	18	types	type	NOUN
gs-3446	367	19	for	for	ADP
gs-3446	367	20	transplantation	transplantation	NOUN
gs-3446	367	21	and	and	CCONJ
gs-3446	367	22	disease	disease	NOUN
gs-3446	367	23	modeling	modeling	NOUN
gs-3446	367	24	.	.	PUNCT
gs-3446	368	1	●	●	PUNCT
gs-3446	368	2	investigate	investigate	VERB
gs-3446	368	3	how	how	SCONJ
gs-3446	368	4	transcriptional	transcriptional	ADJ
gs-3446	368	5	plasticity	plasticity	NOUN
gs-3446	368	6	can	can	AUX
gs-3446	368	7	be	be	AUX
gs-3446	368	8	harnessed	harness	VERB
gs-3446	368	9	to	to	ADP
gs-3446	368	10	reprogram	reprogram	NOUN
gs-3446	368	11	somatic	somatic	ADJ
gs-3446	368	12	cells	cell	NOUN
gs-3446	368	13	into	into	ADP
gs-3446	368	14	therapeutic	therapeutic	ADJ
gs-3446	368	15	cell	cell	NOUN
gs-3446	368	16	types	type	NOUN
gs-3446	368	17	,	,	PUNCT
gs-3446	368	18	reducing	reduce	VERB
gs-3446	368	19	reliance	reliance	NOUN
gs-3446	368	20	on	on	ADP
gs-3446	368	21	embryonic	embryonic	ADJ
gs-3446	368	22	sources	source	NOUN
gs-3446	368	23	.	.	PUNCT
gs-3446	369	1	target	target	VERB
gs-3446	369	2	transcriptional	transcriptional	ADJ
gs-3446	369	3	dysregulation	dysregulation	NOUN
gs-3446	369	4	in	in	ADP
gs-3446	369	5	disease	disease	NOUN
gs-3446	369	6	●	●	PRON
gs-3446	369	7	identify	identify	VERB
gs-3446	369	8	and	and	CCONJ
gs-3446	369	9	inhibit	inhibit	VERB
gs-3446	369	10	key	key	ADJ
gs-3446	369	11	transcriptional	transcriptional	ADJ
gs-3446	369	12	regulators	regulator	NOUN
gs-3446	369	13	driving	drive	VERB
gs-3446	369	14	cancer	cancer	NOUN
gs-3446	369	15	stem	stem	NOUN
gs-3446	369	16	cell	cell	NOUN
gs-3446	369	17	phenotypes	phenotype	NOUN
gs-3446	369	18	to	to	PART
gs-3446	369	19	develop	develop	VERB
gs-3446	369	20	more	more	ADV
gs-3446	369	21	effective	effective	ADJ
gs-3446	369	22	treatments	treatment	NOUN
gs-3446	369	23	for	for	ADP
gs-3446	369	24	stem	stem	NOUN
gs-3446	369	25	cell	cell	NOUN
gs-3446	369	26	-	-	PUNCT
gs-3446	369	27	driven	drive	VERB
gs-3446	369	28	cancers	cancer	NOUN
gs-3446	369	29	.	.	PUNCT
gs-3446	370	1	●	●	PUNCT
gs-3446	370	2	investigate	investigate	VERB
gs-3446	370	3	small	small	ADJ
gs-3446	370	4	molecules	molecule	NOUN
gs-3446	370	5	or	or	CCONJ
gs-3446	370	6	crispr	crispr	NOUN
gs-3446	370	7	-	-	PUNCT
gs-3446	370	8	based	base	VERB
gs-3446	370	9	approaches	approach	NOUN
gs-3446	370	10	to	to	PART
gs-3446	370	11	modulate	modulate	VERB
gs-3446	370	12	aberrant	aberrant	ADJ
gs-3446	370	13	transcriptional	transcriptional	ADJ
gs-3446	370	14	networks	network	NOUN
gs-3446	370	15	in	in	ADP
gs-3446	370	16	degenerative	degenerative	ADJ
gs-3446	370	17	diseases	disease	NOUN
gs-3446	370	18	.	.	PUNCT
gs-3446	371	1	integrate	integrate	VERB
gs-3446	371	2	3d	3d	NUM
gs-3446	371	3	models	model	NOUN
gs-3446	371	4	and	and	CCONJ
gs-3446	371	5	in	in	ADP
gs-3446	371	6	vivo	vivo	ADJ
gs-3446	371	7	validation	validation	NOUN
gs-3446	371	8	●	●	NUM
gs-3446	371	9	use	use	NOUN
gs-3446	371	10	organoids	organoid	NOUN
gs-3446	371	11	and	and	CCONJ
gs-3446	371	12	biomimetic	biomimetic	ADJ
gs-3446	371	13	scaffolds	scaffold	NOUN
gs-3446	371	14	to	to	PART
gs-3446	371	15	better	well	ADV
gs-3446	371	16	replicate	replicate	VERB
gs-3446	371	17	in	in	ADP
gs-3446	371	18	vivo	vivo	ADJ
gs-3446	371	19	transcriptional	transcriptional	ADJ
gs-3446	371	20	dynamics	dynamic	NOUN
gs-3446	371	21	and	and	CCONJ
gs-3446	371	22	cell	cell	NOUN
gs-3446	371	23	-	-	PUNCT
gs-3446	371	24	cell	cell	NOUN
gs-3446	371	25	interactions	interaction	NOUN
gs-3446	371	26	.	.	PUNCT
gs-3446	372	1	●	●	PUNCT
gs-3446	372	2	validate	validate	VERB
gs-3446	372	3	findings	finding	NOUN
gs-3446	372	4	from	from	ADP
gs-3446	372	5	in	in	ADP
gs-3446	372	6	vitro	vitro	X
gs-3446	372	7	studies	study	NOUN
gs-3446	372	8	using	use	VERB
gs-3446	372	9	animal	animal	NOUN
gs-3446	372	10	models	model	NOUN
gs-3446	372	11	and	and	CCONJ
gs-3446	372	12	patient	patient	NOUN
gs-3446	372	13	-	-	PUNCT
gs-3446	372	14	derived	derive	VERB
gs-3446	372	15	cells	cell	NOUN
gs-3446	372	16	to	to	PART
gs-3446	372	17	ensure	ensure	VERB
gs-3446	372	18	clinical	clinical	ADJ
gs-3446	372	19	relevance	relevance	NOUN
gs-3446	372	20	.	.	PUNCT
gs-3446	373	1	georgian	georgian	ADJ
gs-3446	373	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	373	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	373	4	ტ.	ტ.	VERB
gs-3446	373	5	7	7	NUM
gs-3446	373	6	n	n	PRON
gs-3446	373	7	1	1	NUM
gs-3446	373	8	,	,	PUNCT
gs-3446	373	9	2025	2025	NUM
gs-3446	373	10	294	294	NUM
gs-3446	373	11	explore	explore	VERB
gs-3446	373	12	ethical	ethical	ADJ
gs-3446	373	13	and	and	CCONJ
gs-3446	373	14	regulatory	regulatory	ADJ
gs-3446	373	15	considerations	consideration	NOUN
gs-3446	373	16	●	●	PUNCT
gs-3446	373	17	establish	establish	VERB
gs-3446	373	18	standardized	standardized	ADJ
gs-3446	373	19	guidelines	guideline	NOUN
gs-3446	373	20	for	for	ADP
gs-3446	373	21	genetic	genetic	ADJ
gs-3446	373	22	and	and	CCONJ
gs-3446	373	23	transcriptional	transcriptional	ADJ
gs-3446	373	24	modifications	modification	NOUN
gs-3446	373	25	in	in	ADP
gs-3446	373	26	stem	stem	NOUN
gs-3446	373	27	cell	cell	NOUN
gs-3446	373	28	research	research	NOUN
gs-3446	373	29	.	.	PUNCT
gs-3446	374	1	●	●	PUNCT
gs-3446	374	2	address	address	NOUN
gs-3446	374	3	ethical	ethical	ADJ
gs-3446	374	4	concerns	concern	NOUN
gs-3446	374	5	regarding	regard	VERB
gs-3446	374	6	stem	stem	NOUN
gs-3446	374	7	cell	cell	NOUN
gs-3446	374	8	reprogramming	reprogramme	VERB
gs-3446	374	9	and	and	CCONJ
gs-3446	374	10	genome	genome	NOUN
gs-3446	374	11	editing	editing	NOUN
gs-3446	374	12	,	,	PUNCT
gs-3446	374	13	ensuring	ensure	VERB
gs-3446	374	14	responsible	responsible	ADJ
gs-3446	374	15	biomedical	biomedical	ADJ
gs-3446	374	16	applications	application	NOUN
gs-3446	374	17	.	.	PUNCT
gs-3446	375	1	to	to	ADP
gs-3446	375	2	fully	fully	ADV
gs-3446	375	3	harness	harness	ADJ
gs-3446	375	4	stem	stem	NOUN
gs-3446	375	5	cell	cell	NOUN
gs-3446	375	6	potential	potential	NOUN
gs-3446	375	7	,	,	PUNCT
gs-3446	375	8	interdisciplinary	interdisciplinary	ADJ
gs-3446	375	9	efforts	effort	NOUN
gs-3446	375	10	integrating	integrate	VERB
gs-3446	375	11	transcriptomics	transcriptomic	NOUN
gs-3446	375	12	,	,	PUNCT
gs-3446	375	13	bioengineering	bioengineering	NOUN
gs-3446	375	14	,	,	PUNCT
gs-3446	375	15	and	and	CCONJ
gs-3446	375	16	clinical	clinical	ADJ
gs-3446	375	17	research	research	NOUN
gs-3446	375	18	are	be	AUX
gs-3446	375	19	essential	essential	ADJ
gs-3446	375	20	.	.	PUNCT
gs-3446	376	1	by	by	ADP
gs-3446	376	2	refining	refine	VERB
gs-3446	376	3	our	our	PRON
gs-3446	376	4	understanding	understanding	NOUN
gs-3446	376	5	of	of	ADP
gs-3446	376	6	transcriptional	transcriptional	ADJ
gs-3446	376	7	circuits	circuit	NOUN
gs-3446	376	8	,	,	PUNCT
gs-3446	376	9	we	we	PRON
gs-3446	376	10	can	can	AUX
gs-3446	376	11	improve	improve	VERB
gs-3446	376	12	regenerative	regenerative	ADJ
gs-3446	376	13	therapies	therapy	NOUN
gs-3446	376	14	,	,	PUNCT
gs-3446	376	15	disease	disease	NOUN
gs-3446	376	16	modeling	modeling	NOUN
gs-3446	376	17	,	,	PUNCT
gs-3446	376	18	and	and	CCONJ
gs-3446	376	19	precision	precision	NOUN
gs-3446	376	20	medicine	medicine	NOUN
gs-3446	376	21	approaches	approach	NOUN
gs-3446	376	22	,	,	PUNCT
gs-3446	376	23	ultimately	ultimately	ADV
gs-3446	376	24	translating	translate	VERB
gs-3446	376	25	stem	stem	NOUN
gs-3446	376	26	cell	cell	NOUN
gs-3446	376	27	research	research	NOUN
gs-3446	376	28	into	into	ADP
gs-3446	376	29	impactful	impactful	ADJ
gs-3446	376	30	clinical	clinical	ADJ
gs-3446	376	31	solutions	solution	NOUN
gs-3446	376	32	(	(	PUNCT
gs-3446	376	33	vandana	vandana	PROPN
gs-3446	376	34	et	et	PROPN
gs-3446	376	35	al	al	PROPN
gs-3446	376	36	.	.	PROPN
gs-3446	376	37	2023	2023	NUM
gs-3446	376	38	)	)	PUNCT
gs-3446	376	39	.	.	PUNCT
gs-3446	377	1	stem	stem	NOUN
gs-3446	377	2	cells	cell	NOUN
gs-3446	377	3	homeostasis	homeostasis	NOUN
gs-3446	377	4	stem	stem	NOUN
gs-3446	377	5	cell	cell	NOUN
gs-3446	377	6	homeostasis	homeostasis	NOUN
gs-3446	377	7	refers	refer	VERB
gs-3446	377	8	to	to	ADP
gs-3446	377	9	the	the	DET
gs-3446	377	10	delicate	delicate	ADJ
gs-3446	377	11	balance	balance	NOUN
gs-3446	377	12	that	that	PRON
gs-3446	377	13	maintains	maintain	VERB
gs-3446	377	14	the	the	DET
gs-3446	377	15	self	self	NOUN
gs-3446	377	16	-	-	PUNCT
gs-3446	377	17	renewal	renewal	NOUN
gs-3446	377	18	and	and	CCONJ
gs-3446	377	19	differentiation	differentiation	NOUN
gs-3446	377	20	capabilities	capability	NOUN
gs-3446	377	21	of	of	ADP
gs-3446	377	22	stem	stem	NOUN
gs-3446	377	23	cells	cell	NOUN
gs-3446	377	24	throughout	throughout	ADP
gs-3446	377	25	an	an	DET
gs-3446	377	26	organism	organism	NOUN
gs-3446	377	27	's	's	PART
gs-3446	377	28	lifespan	lifespan	NOUN
gs-3446	377	29	.	.	PUNCT
gs-3446	378	1	this	this	DET
gs-3446	378	2	balance	balance	NOUN
gs-3446	378	3	is	be	AUX
gs-3446	378	4	crucial	crucial	ADJ
gs-3446	378	5	for	for	ADP
gs-3446	378	6	tissue	tissue	NOUN
gs-3446	378	7	maintenance	maintenance	NOUN
gs-3446	378	8	,	,	PUNCT
gs-3446	378	9	repair	repair	NOUN
gs-3446	378	10	,	,	PUNCT
gs-3446	378	11	and	and	CCONJ
gs-3446	378	12	regeneration	regeneration	NOUN
gs-3446	378	13	.	.	PUNCT
gs-3446	379	1	homeostasis	homeostasis	NOUN
gs-3446	379	2	is	be	AUX
gs-3446	379	3	regulated	regulate	VERB
gs-3446	379	4	by	by	ADP
gs-3446	379	5	intrinsic	intrinsic	ADJ
gs-3446	379	6	factors	factor	NOUN
gs-3446	379	7	,	,	PUNCT
gs-3446	379	8	such	such	ADJ
gs-3446	379	9	as	as	ADP
gs-3446	379	10	genetic	genetic	ADJ
gs-3446	379	11	and	and	CCONJ
gs-3446	379	12	epigenetic	epigenetic	ADJ
gs-3446	379	13	mechanisms	mechanism	NOUN
gs-3446	379	14	,	,	PUNCT
gs-3446	379	15	as	as	ADV
gs-3446	379	16	well	well	ADV
gs-3446	379	17	as	as	ADP
gs-3446	379	18	extrinsic	extrinsic	ADJ
gs-3446	379	19	factors	factor	NOUN
gs-3446	379	20	,	,	PUNCT
gs-3446	379	21	including	include	VERB
gs-3446	379	22	signaling	signal	VERB
gs-3446	379	23	from	from	ADP
gs-3446	379	24	the	the	DET
gs-3446	379	25	stem	stem	NOUN
gs-3446	379	26	cell	cell	NOUN
gs-3446	379	27	niche	niche	NOUN
gs-3446	379	28	and	and	CCONJ
gs-3446	379	29	systemic	systemic	ADJ
gs-3446	379	30	influences	influence	NOUN
gs-3446	379	31	like	like	ADP
gs-3446	379	32	hormones	hormone	NOUN
gs-3446	379	33	and	and	CCONJ
gs-3446	379	34	inflammatory	inflammatory	ADJ
gs-3446	379	35	signals	signal	NOUN
gs-3446	379	36	.	.	PUNCT
gs-3446	380	1	disruptions	disruption	NOUN
gs-3446	380	2	in	in	ADP
gs-3446	380	3	stem	stem	NOUN
gs-3446	380	4	cell	cell	NOUN
gs-3446	380	5	homeostasis	homeostasis	NOUN
gs-3446	380	6	can	can	AUX
gs-3446	380	7	lead	lead	VERB
gs-3446	380	8	to	to	ADP
gs-3446	380	9	aging	age	VERB
gs-3446	380	10	,	,	PUNCT
gs-3446	380	11	degenerative	degenerative	ADJ
gs-3446	380	12	diseases	disease	NOUN
gs-3446	380	13	,	,	PUNCT
gs-3446	380	14	or	or	CCONJ
gs-3446	380	15	cancer	cancer	NOUN
gs-3446	380	16	.	.	PUNCT
gs-3446	381	1	understanding	understand	VERB
gs-3446	381	2	the	the	DET
gs-3446	381	3	mechanisms	mechanism	NOUN
gs-3446	381	4	governing	govern	VERB
gs-3446	381	5	stem	stem	NOUN
gs-3446	381	6	cell	cell	NOUN
gs-3446	381	7	equilibrium	equilibrium	NOUN
gs-3446	381	8	is	be	AUX
gs-3446	381	9	essential	essential	ADJ
gs-3446	381	10	for	for	ADP
gs-3446	381	11	advancing	advance	VERB
gs-3446	381	12	regenerative	regenerative	ADJ
gs-3446	381	13	medicine	medicine	NOUN
gs-3446	381	14	and	and	CCONJ
gs-3446	381	15	therapeutic	therapeutic	ADJ
gs-3446	381	16	interventions	intervention	NOUN
gs-3446	381	17	(	(	PUNCT
gs-3446	381	18	aphkhazava	aphkhazava	NOUN
gs-3446	381	19	et	et	PROPN
gs-3446	381	20	al	al	PROPN
gs-3446	381	21	.	.	PROPN
gs-3446	381	22	2024	2024	NUM
gs-3446	381	23	)	)	PUNCT
gs-3446	381	24	.	.	PUNCT
gs-3446	382	1	stem	stem	NOUN
gs-3446	382	2	cell	cell	NOUN
gs-3446	382	3	homeostasis	homeostasis	NOUN
gs-3446	382	4	is	be	AUX
gs-3446	382	5	the	the	DET
gs-3446	382	6	dynamic	dynamic	ADJ
gs-3446	382	7	process	process	NOUN
gs-3446	382	8	that	that	PRON
gs-3446	382	9	ensures	ensure	VERB
gs-3446	382	10	a	a	DET
gs-3446	382	11	stable	stable	ADJ
gs-3446	382	12	population	population	NOUN
gs-3446	382	13	of	of	ADP
gs-3446	382	14	stem	stem	NOUN
gs-3446	382	15	cells	cell	NOUN
gs-3446	382	16	while	while	SCONJ
gs-3446	382	17	allowing	allow	VERB
gs-3446	382	18	for	for	ADP
gs-3446	382	19	the	the	DET
gs-3446	382	20	generation	generation	NOUN
gs-3446	382	21	of	of	ADP
gs-3446	382	22	differentiated	differentiated	ADJ
gs-3446	382	23	cells	cell	NOUN
gs-3446	382	24	needed	need	VERB
gs-3446	382	25	for	for	ADP
gs-3446	382	26	tissue	tissue	NOUN
gs-3446	382	27	growth	growth	NOUN
gs-3446	382	28	,	,	PUNCT
gs-3446	382	29	maintenance	maintenance	NOUN
gs-3446	382	30	,	,	PUNCT
gs-3446	382	31	and	and	CCONJ
gs-3446	382	32	repair	repair	NOUN
gs-3446	382	33	.	.	PUNCT
gs-3446	383	1	this	this	DET
gs-3446	383	2	balance	balance	NOUN
gs-3446	383	3	is	be	AUX
gs-3446	383	4	maintained	maintain	VERB
gs-3446	383	5	through	through	ADP
gs-3446	383	6	tightly	tightly	ADV
gs-3446	383	7	regulated	regulate	VERB
gs-3446	383	8	mechanisms	mechanism	NOUN
gs-3446	383	9	that	that	PRON
gs-3446	383	10	control	control	VERB
gs-3446	383	11	stem	stem	NOUN
gs-3446	383	12	cell	cell	NOUN
gs-3446	383	13	self	self	NOUN
gs-3446	383	14	-	-	PUNCT
gs-3446	383	15	renewal	renewal	NOUN
gs-3446	383	16	,	,	PUNCT
gs-3446	383	17	proliferation	proliferation	NOUN
gs-3446	383	18	,	,	PUNCT
gs-3446	383	19	quiescence	quiescence	NOUN
gs-3446	383	20	,	,	PUNCT
gs-3446	383	21	and	and	CCONJ
gs-3446	383	22	differentiation	differentiation	NOUN
gs-3446	383	23	.	.	PUNCT
gs-3446	384	1	homeostasis	homeostasis	NOUN
gs-3446	384	2	is	be	AUX
gs-3446	384	3	governed	govern	VERB
gs-3446	384	4	by	by	ADP
gs-3446	384	5	both	both	DET
gs-3446	384	6	intrinsic	intrinsic	ADJ
gs-3446	384	7	factors	factor	NOUN
gs-3446	384	8	,	,	PUNCT
gs-3446	384	9	including	include	VERB
gs-3446	384	10	gene	gene	NOUN
gs-3446	384	11	expression	expression	NOUN
gs-3446	384	12	programs	program	NOUN
gs-3446	384	13	,	,	PUNCT
gs-3446	384	14	epigenetic	epigenetic	ADJ
gs-3446	384	15	modifications	modification	NOUN
gs-3446	384	16	,	,	PUNCT
gs-3446	384	17	and	and	CCONJ
gs-3446	384	18	metabolic	metabolic	NOUN
gs-3446	384	19	regulation	regulation	NOUN
gs-3446	384	20	,	,	PUNCT
gs-3446	384	21	and	and	CCONJ
gs-3446	384	22	extrinsic	extrinsic	ADJ
gs-3446	384	23	factors	factor	NOUN
gs-3446	384	24	,	,	PUNCT
gs-3446	384	25	such	such	ADJ
gs-3446	384	26	as	as	ADP
gs-3446	384	27	signals	signal	NOUN
gs-3446	384	28	from	from	ADP
gs-3446	384	29	the	the	DET
gs-3446	384	30	stem	stem	NOUN
gs-3446	384	31	cell	cell	NOUN
gs-3446	384	32	niche	niche	NOUN
gs-3446	384	33	,	,	PUNCT
gs-3446	384	34	systemic	systemic	ADJ
gs-3446	384	35	hormones	hormone	NOUN
gs-3446	384	36	,	,	PUNCT
gs-3446	384	37	and	and	CCONJ
gs-3446	384	38	environmental	environmental	ADJ
gs-3446	384	39	influences	influence	NOUN
gs-3446	384	40	.	.	PUNCT
gs-3446	385	1	stem	stem	NOUN
gs-3446	385	2	cells	cell	NOUN
gs-3446	385	3	exist	exist	VERB
gs-3446	385	4	in	in	ADP
gs-3446	385	5	specialized	specialized	ADJ
gs-3446	385	6	microenvironments	microenvironment	NOUN
gs-3446	385	7	,	,	PUNCT
gs-3446	385	8	or	or	CCONJ
gs-3446	385	9	niches	niche	NOUN
gs-3446	385	10	,	,	PUNCT
gs-3446	385	11	that	that	PRON
gs-3446	385	12	provide	provide	VERB
gs-3446	385	13	crucial	crucial	ADJ
gs-3446	385	14	signals	signal	NOUN
gs-3446	385	15	to	to	PART
gs-3446	385	16	sustain	sustain	VERB
gs-3446	385	17	their	their	PRON
gs-3446	385	18	function	function	NOUN
gs-3446	385	19	and	and	CCONJ
gs-3446	385	20	prevent	prevent	VERB
gs-3446	385	21	exhaustion	exhaustion	NOUN
gs-3446	385	22	or	or	CCONJ
gs-3446	385	23	over	over	ADP
gs-3446	385	24	-	-	PUNCT
gs-3446	385	25	proliferation	proliferation	NOUN
gs-3446	385	26	.	.	PUNCT
gs-3446	386	1	these	these	DET
gs-3446	386	2	signals	signal	NOUN
gs-3446	386	3	include	include	VERB
gs-3446	386	4	growth	growth	NOUN
gs-3446	386	5	factors	factor	NOUN
gs-3446	386	6	,	,	PUNCT
gs-3446	386	7	cytokines	cytokine	NOUN
gs-3446	386	8	,	,	PUNCT
gs-3446	386	9	and	and	CCONJ
gs-3446	386	10	extracellular	extracellular	ADJ
gs-3446	386	11	matrix	matrix	NOUN
gs-3446	386	12	interactions	interaction	NOUN
gs-3446	386	13	that	that	PRON
gs-3446	386	14	help	help	VERB
gs-3446	386	15	maintain	maintain	VERB
gs-3446	386	16	stem	stem	NOUN
gs-3446	386	17	cell	cell	NOUN
gs-3446	386	18	identity	identity	NOUN
gs-3446	386	19	and	and	CCONJ
gs-3446	386	20	guide	guide	VERB
gs-3446	386	21	their	their	PRON
gs-3446	386	22	behavior	behavior	NOUN
gs-3446	386	23	in	in	ADP
gs-3446	386	24	response	response	NOUN
gs-3446	386	25	to	to	ADP
gs-3446	386	26	physiological	physiological	ADJ
gs-3446	386	27	needs	need	NOUN
gs-3446	386	28	.	.	PUNCT
gs-3446	387	1	the	the	DET
gs-3446	387	2	disruption	disruption	NOUN
gs-3446	387	3	of	of	ADP
gs-3446	387	4	stem	stem	NOUN
gs-3446	387	5	cell	cell	NOUN
gs-3446	387	6	homeostasis	homeostasis	NOUN
gs-3446	387	7	is	be	AUX
gs-3446	387	8	implicated	implicate	VERB
gs-3446	387	9	in	in	ADP
gs-3446	387	10	various	various	ADJ
gs-3446	387	11	pathological	pathological	ADJ
gs-3446	387	12	conditions	condition	NOUN
gs-3446	387	13	.	.	PUNCT
gs-3446	388	1	excessive	excessive	ADJ
gs-3446	388	2	selfrenewal	selfrenewal	NOUN
gs-3446	388	3	can	can	AUX
gs-3446	388	4	lead	lead	VERB
gs-3446	388	5	to	to	ADP
gs-3446	388	6	tumorigenesis	tumorigenesis	NOUN
gs-3446	388	7	,	,	PUNCT
gs-3446	388	8	as	as	SCONJ
gs-3446	388	9	seen	see	VERB
gs-3446	388	10	in	in	ADP
gs-3446	388	11	cancers	cancer	NOUN
gs-3446	388	12	with	with	ADP
gs-3446	388	13	uncontrolled	uncontrolled	ADJ
gs-3446	388	14	stem	stem	NOUN
gs-3446	388	15	cell	cell	NOUN
gs-3446	388	16	proliferation	proliferation	NOUN
gs-3446	388	17	.	.	PUNCT
gs-3446	389	1	conversely	conversely	ADV
gs-3446	389	2	,	,	PUNCT
gs-3446	389	3	impaired	impaired	ADJ
gs-3446	389	4	self	self	NOUN
gs-3446	389	5	-	-	PUNCT
gs-3446	389	6	renewal	renewal	NOUN
gs-3446	389	7	or	or	CCONJ
gs-3446	389	8	excessive	excessive	ADJ
gs-3446	389	9	differentiation	differentiation	NOUN
gs-3446	389	10	can	can	AUX
gs-3446	389	11	contribute	contribute	VERB
gs-3446	389	12	to	to	ADP
gs-3446	389	13	tissue	tissue	NOUN
gs-3446	389	14	degeneration	degeneration	NOUN
gs-3446	389	15	,	,	PUNCT
gs-3446	389	16	aging	aging	NOUN
gs-3446	389	17	,	,	PUNCT
gs-3446	389	18	and	and	CCONJ
gs-3446	389	19	impaired	impaired	ADJ
gs-3446	389	20	healing	healing	NOUN
gs-3446	389	21	.	.	PUNCT
gs-3446	390	1	understanding	understand	VERB
gs-3446	390	2	the	the	DET
gs-3446	390	3	molecular	molecular	ADJ
gs-3446	390	4	and	and	CCONJ
gs-3446	390	5	cellular	cellular	ADJ
gs-3446	390	6	mechanisms	mechanism	NOUN
gs-3446	390	7	underlying	underlie	VERB
gs-3446	390	8	stem	stem	NOUN
gs-3446	390	9	cell	cell	NOUN
gs-3446	390	10	homeostasis	homeostasis	NOUN
gs-3446	390	11	is	be	AUX
gs-3446	390	12	critical	critical	ADJ
gs-3446	390	13	for	for	ADP
gs-3446	390	14	developing	develop	VERB
gs-3446	390	15	regenerative	regenerative	ADJ
gs-3446	390	16	therapies	therapy	NOUN
gs-3446	390	17	,	,	PUNCT
gs-3446	390	18	improving	improve	VERB
gs-3446	390	19	tissue	tissue	NOUN
gs-3446	390	20	engineering	engineering	NOUN
gs-3446	390	21	approaches	approach	NOUN
gs-3446	390	22	,	,	PUNCT
gs-3446	390	23	and	and	CCONJ
gs-3446	390	24	combating	combat	VERB
gs-3446	390	25	age	age	NOUN
gs-3446	390	26	-	-	PUNCT
gs-3446	390	27	related	relate	VERB
gs-3446	390	28	diseases	disease	NOUN
gs-3446	390	29	(	(	PUNCT
gs-3446	390	30	aphkhazava	aphkhazava	NOUN
gs-3446	390	31	et	et	PROPN
gs-3446	390	32	al	al	PROPN
gs-3446	390	33	.	.	PROPN
gs-3446	390	34	2024	2024	NUM
gs-3446	390	35	)	)	PUNCT
gs-3446	390	36	.	.	PUNCT
gs-3446	391	1	georgian	georgian	ADJ
gs-3446	391	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	391	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	391	4	ტ.	ტ.	VERB
gs-3446	391	5	7	7	NUM
gs-3446	391	6	n	n	PRON
gs-3446	391	7	1	1	NUM
gs-3446	391	8	,	,	PUNCT
gs-3446	391	9	2025	2025	NUM
gs-3446	391	10	295	295	NUM
gs-3446	391	11	ongoing	ongoing	ADJ
gs-3446	391	12	research	research	NOUN
gs-3446	391	13	continues	continue	VERB
gs-3446	391	14	to	to	PART
gs-3446	391	15	uncover	uncover	VERB
gs-3446	391	16	the	the	DET
gs-3446	391	17	complexity	complexity	NOUN
gs-3446	391	18	of	of	ADP
gs-3446	391	19	stem	stem	NOUN
gs-3446	391	20	cell	cell	NOUN
gs-3446	391	21	regulation	regulation	NOUN
gs-3446	391	22	,	,	PUNCT
gs-3446	391	23	offering	offer	VERB
gs-3446	391	24	new	new	ADJ
gs-3446	391	25	insights	insight	NOUN
gs-3446	391	26	into	into	ADP
gs-3446	391	27	how	how	SCONJ
gs-3446	391	28	homeostasis	homeostasis	NOUN
gs-3446	391	29	is	be	AUX
gs-3446	391	30	maintained	maintain	VERB
gs-3446	391	31	across	across	ADP
gs-3446	391	32	different	different	ADJ
gs-3446	391	33	tissues	tissue	NOUN
gs-3446	391	34	and	and	CCONJ
gs-3446	391	35	organisms	organism	NOUN
gs-3446	391	36	.	.	PUNCT
gs-3446	392	1	advances	advance	NOUN
gs-3446	392	2	in	in	ADP
gs-3446	392	3	stem	stem	NOUN
gs-3446	392	4	cell	cell	NOUN
gs-3446	392	5	biology	biology	NOUN
gs-3446	392	6	hold	hold	VERB
gs-3446	392	7	great	great	ADJ
gs-3446	392	8	potential	potential	NOUN
gs-3446	392	9	for	for	ADP
gs-3446	392	10	medical	medical	ADJ
gs-3446	392	11	applications	application	NOUN
gs-3446	392	12	,	,	PUNCT
gs-3446	392	13	including	include	VERB
gs-3446	392	14	stem	stem	NOUN
gs-3446	392	15	cell	cell	NOUN
gs-3446	392	16	-	-	PUNCT
gs-3446	392	17	based	base	VERB
gs-3446	392	18	therapies	therapy	NOUN
gs-3446	392	19	for	for	ADP
gs-3446	392	20	degenerative	degenerative	ADJ
gs-3446	392	21	diseases	disease	NOUN
gs-3446	392	22	,	,	PUNCT
gs-3446	392	23	injury	injury	NOUN
gs-3446	392	24	repair	repair	NOUN
gs-3446	392	25	,	,	PUNCT
gs-3446	392	26	and	and	CCONJ
gs-3446	392	27	organ	organ	NOUN
gs-3446	392	28	regeneration	regeneration	NOUN
gs-3446	392	29	.	.	PUNCT
gs-3446	393	1	stem	stem	NOUN
gs-3446	393	2	cells	cell	NOUN
gs-3446	393	3	are	be	AUX
gs-3446	393	4	undifferentiated	undifferentiated	ADJ
gs-3446	393	5	cells	cell	NOUN
gs-3446	393	6	with	with	ADP
gs-3446	393	7	the	the	DET
gs-3446	393	8	unique	unique	ADJ
gs-3446	393	9	ability	ability	NOUN
gs-3446	393	10	to	to	PART
gs-3446	393	11	self	self	NOUN
gs-3446	393	12	-	-	PUNCT
gs-3446	393	13	renew	renew	VERB
gs-3446	393	14	and	and	CCONJ
gs-3446	393	15	differentiate	differentiate	VERB
gs-3446	393	16	into	into	ADP
gs-3446	393	17	specialized	specialized	ADJ
gs-3446	393	18	cell	cell	NOUN
gs-3446	393	19	types	type	NOUN
gs-3446	393	20	.	.	PUNCT
gs-3446	394	1	they	they	PRON
gs-3446	394	2	play	play	VERB
gs-3446	394	3	a	a	DET
gs-3446	394	4	fundamental	fundamental	ADJ
gs-3446	394	5	role	role	NOUN
gs-3446	394	6	in	in	ADP
gs-3446	394	7	development	development	NOUN
gs-3446	394	8	,	,	PUNCT
gs-3446	394	9	tissue	tissue	NOUN
gs-3446	394	10	maintenance	maintenance	NOUN
gs-3446	394	11	,	,	PUNCT
gs-3446	394	12	and	and	CCONJ
gs-3446	394	13	regeneration	regeneration	NOUN
gs-3446	394	14	.	.	PUNCT
gs-3446	395	1	the	the	DET
gs-3446	395	2	concept	concept	NOUN
gs-3446	395	3	of	of	ADP
gs-3446	395	4	stem	stem	NOUN
gs-3446	395	5	cell	cell	NOUN
gs-3446	395	6	homeostasis	homeostasis	NOUN
gs-3446	395	7	refers	refer	VERB
gs-3446	395	8	to	to	ADP
gs-3446	395	9	the	the	DET
gs-3446	395	10	precise	precise	ADJ
gs-3446	395	11	regulation	regulation	NOUN
gs-3446	395	12	of	of	ADP
gs-3446	395	13	stem	stem	NOUN
gs-3446	395	14	cell	cell	NOUN
gs-3446	395	15	populations	population	NOUN
gs-3446	395	16	to	to	PART
gs-3446	395	17	ensure	ensure	VERB
gs-3446	395	18	a	a	DET
gs-3446	395	19	balance	balance	NOUN
gs-3446	395	20	between	between	ADP
gs-3446	395	21	self	self	NOUN
gs-3446	395	22	-	-	PUNCT
gs-3446	395	23	renewal	renewal	NOUN
gs-3446	395	24	and	and	CCONJ
gs-3446	395	25	differentiation	differentiation	NOUN
gs-3446	395	26	,	,	PUNCT
gs-3446	395	27	preventing	prevent	VERB
gs-3446	395	28	depletion	depletion	NOUN
gs-3446	395	29	or	or	CCONJ
gs-3446	395	30	uncontrolled	uncontrolled	ADJ
gs-3446	395	31	proliferation	proliferation	NOUN
gs-3446	395	32	.	.	PUNCT
gs-3446	396	1	stem	stem	NOUN
gs-3446	396	2	cell	cell	NOUN
gs-3446	396	3	homeostasis	homeostasis	NOUN
gs-3446	396	4	is	be	AUX
gs-3446	396	5	fundamental	fundamental	ADJ
gs-3446	396	6	for	for	ADP
gs-3446	396	7	tissue	tissue	NOUN
gs-3446	396	8	maintenance	maintenance	NOUN
gs-3446	396	9	,	,	PUNCT
gs-3446	396	10	repair	repair	NOUN
gs-3446	396	11	,	,	PUNCT
gs-3446	396	12	and	and	CCONJ
gs-3446	396	13	disease	disease	NOUN
gs-3446	396	14	prevention	prevention	NOUN
gs-3446	396	15	.	.	PUNCT
gs-3446	397	1	disruptions	disruption	NOUN
gs-3446	397	2	in	in	ADP
gs-3446	397	3	homeostasis	homeostasis	NOUN
gs-3446	397	4	contribute	contribute	NOUN
gs-3446	397	5	to	to	ADP
gs-3446	397	6	aging	age	VERB
gs-3446	397	7	,	,	PUNCT
gs-3446	397	8	degenerative	degenerative	ADJ
gs-3446	397	9	disorders	disorder	NOUN
gs-3446	397	10	,	,	PUNCT
gs-3446	397	11	and	and	CCONJ
gs-3446	397	12	cancer	cancer	NOUN
gs-3446	397	13	,	,	PUNCT
gs-3446	397	14	highlighting	highlight	VERB
gs-3446	397	15	the	the	DET
gs-3446	397	16	need	need	NOUN
gs-3446	397	17	for	for	ADP
gs-3446	397	18	targeted	target	VERB
gs-3446	397	19	therapeutic	therapeutic	ADJ
gs-3446	397	20	strategies	strategy	NOUN
gs-3446	397	21	.	.	PUNCT
gs-3446	398	1	ongoing	ongoing	ADJ
gs-3446	398	2	research	research	NOUN
gs-3446	398	3	in	in	ADP
gs-3446	398	4	regenerative	regenerative	ADJ
gs-3446	398	5	medicine	medicine	NOUN
gs-3446	398	6	,	,	PUNCT
gs-3446	398	7	gene	gene	NOUN
gs-3446	398	8	editing	editing	NOUN
gs-3446	398	9	,	,	PUNCT
gs-3446	398	10	and	and	CCONJ
gs-3446	398	11	cancer	cancer	NOUN
gs-3446	398	12	therapy	therapy	NOUN
gs-3446	398	13	aims	aim	VERB
gs-3446	398	14	to	to	ADP
gs-3446	398	15	harness	harness	ADJ
gs-3446	398	16	stem	stem	NOUN
gs-3446	398	17	cell	cell	NOUN
gs-3446	398	18	potential	potential	NOUN
gs-3446	398	19	while	while	SCONJ
gs-3446	398	20	addressing	address	VERB
gs-3446	398	21	associated	associated	ADJ
gs-3446	398	22	risks	risk	NOUN
gs-3446	398	23	.	.	PUNCT
gs-3446	399	1	future	future	ADJ
gs-3446	399	2	advancements	advancement	NOUN
gs-3446	399	3	in	in	ADP
gs-3446	399	4	bioengineering	bioengineering	NOUN
gs-3446	399	5	,	,	PUNCT
gs-3446	399	6	personalized	personalized	ADJ
gs-3446	399	7	medicine	medicine	NOUN
gs-3446	399	8	,	,	PUNCT
gs-3446	399	9	and	and	CCONJ
gs-3446	399	10	synthetic	synthetic	ADJ
gs-3446	399	11	biology	biology	NOUN
gs-3446	399	12	will	will	AUX
gs-3446	399	13	further	far	ADV
gs-3446	399	14	refine	refine	VERB
gs-3446	399	15	our	our	PRON
gs-3446	399	16	ability	ability	NOUN
gs-3446	399	17	to	to	PART
gs-3446	399	18	manipulate	manipulate	VERB
gs-3446	399	19	stem	stem	NOUN
gs-3446	399	20	cell	cell	NOUN
gs-3446	399	21	homeostasis	homeostasis	NOUN
gs-3446	399	22	for	for	ADP
gs-3446	399	23	improved	improved	ADJ
gs-3446	399	24	health	health	NOUN
gs-3446	399	25	outcomes	outcome	NOUN
gs-3446	399	26	.	.	PUNCT
gs-3446	400	1	stem	stem	NOUN
gs-3446	400	2	cells	cell	NOUN
gs-3446	400	3	are	be	AUX
gs-3446	400	4	classified	classify	VERB
gs-3446	400	5	into	into	ADP
gs-3446	400	6	embryonic	embryonic	ADJ
gs-3446	400	7	stem	stem	NOUN
gs-3446	400	8	cells	cell	NOUN
gs-3446	400	9	(	(	PUNCT
gs-3446	400	10	escs	esc	NOUN
gs-3446	400	11	)	)	PUNCT
gs-3446	400	12	and	and	CCONJ
gs-3446	400	13	adult	adult	NOUN
gs-3446	400	14	(	(	PUNCT
gs-3446	400	15	somatic	somatic	ADJ
gs-3446	400	16	)	)	PUNCT
gs-3446	400	17	stem	stem	NOUN
gs-3446	400	18	cells	cell	NOUN
gs-3446	400	19	.	.	PUNCT
gs-3446	401	1	escs	esc	NOUN
gs-3446	401	2	,	,	PUNCT
gs-3446	401	3	derived	derive	VERB
gs-3446	401	4	from	from	ADP
gs-3446	401	5	the	the	DET
gs-3446	401	6	inner	inner	ADJ
gs-3446	401	7	cell	cell	NOUN
gs-3446	401	8	mass	mass	NOUN
gs-3446	401	9	of	of	ADP
gs-3446	401	10	blastocysts	blastocyst	NOUN
gs-3446	401	11	,	,	PUNCT
gs-3446	401	12	have	have	VERB
gs-3446	401	13	pluripotent	pluripotent	ADJ
gs-3446	401	14	capabilities	capability	NOUN
gs-3446	401	15	,	,	PUNCT
gs-3446	401	16	meaning	mean	VERB
gs-3446	401	17	they	they	PRON
gs-3446	401	18	can	can	AUX
gs-3446	401	19	generate	generate	VERB
gs-3446	401	20	all	all	DET
gs-3446	401	21	three	three	NUM
gs-3446	401	22	germ	germ	NOUN
gs-3446	401	23	layers	layer	NOUN
gs-3446	401	24	—	—	PUNCT
gs-3446	401	25	ectoderm	ectoderm	NOUN
gs-3446	401	26	,	,	PUNCT
gs-3446	401	27	mesoderm	mesoderm	NOUN
gs-3446	401	28	,	,	PUNCT
gs-3446	401	29	and	and	CCONJ
gs-3446	401	30	endoderm	endoderm	NOUN
gs-3446	401	31	.	.	PUNCT
gs-3446	402	1	in	in	ADP
gs-3446	402	2	contrast	contrast	NOUN
gs-3446	402	3	,	,	PUNCT
gs-3446	402	4	adult	adult	NOUN
gs-3446	402	5	stem	stem	NOUN
gs-3446	402	6	cells	cell	NOUN
gs-3446	402	7	,	,	PUNCT
gs-3446	402	8	such	such	ADJ
gs-3446	402	9	as	as	ADP
gs-3446	402	10	hematopoietic	hematopoietic	ADJ
gs-3446	402	11	stem	stem	NOUN
gs-3446	402	12	cells	cell	NOUN
gs-3446	402	13	(	(	PUNCT
gs-3446	402	14	hscs	hsc	NOUN
gs-3446	402	15	)	)	PUNCT
gs-3446	402	16	,	,	PUNCT
gs-3446	402	17	mesenchymal	mesenchymal	NOUN
gs-3446	402	18	stem	stem	NOUN
gs-3446	402	19	cells	cell	NOUN
gs-3446	402	20	(	(	PUNCT
gs-3446	402	21	mscs	msc	NOUN
gs-3446	402	22	)	)	PUNCT
gs-3446	402	23	,	,	PUNCT
gs-3446	402	24	and	and	CCONJ
gs-3446	402	25	neural	neural	ADJ
gs-3446	402	26	stem	stem	NOUN
gs-3446	402	27	cells	cell	NOUN
gs-3446	402	28	(	(	PUNCT
gs-3446	402	29	nscs	nscs	PROPN
gs-3446	402	30	)	)	PUNCT
gs-3446	402	31	,	,	PUNCT
gs-3446	402	32	have	have	VERB
gs-3446	402	33	a	a	DET
gs-3446	402	34	more	more	ADV
gs-3446	402	35	restricted	restricted	ADJ
gs-3446	402	36	differentiation	differentiation	NOUN
gs-3446	402	37	potential	potential	NOUN
gs-3446	402	38	and	and	CCONJ
gs-3446	402	39	primarily	primarily	ADV
gs-3446	402	40	contribute	contribute	VERB
gs-3446	402	41	to	to	ADP
gs-3446	402	42	tissue	tissue	NOUN
gs-3446	402	43	-	-	PUNCT
gs-3446	402	44	specific	specific	ADJ
gs-3446	402	45	regeneration	regeneration	NOUN
gs-3446	402	46	(	(	PUNCT
gs-3446	402	47	scharf	scharf	NOUN
gs-3446	402	48	et	et	PROPN
gs-3446	402	49	al	al	PROPN
gs-3446	402	50	.	.	PROPN
gs-3446	402	51	2013	2013	NUM
gs-3446	402	52	)	)	PUNCT
gs-3446	402	53	.	.	PUNCT
gs-3446	403	1	stem	stem	NOUN
gs-3446	403	2	cell	cell	NOUN
gs-3446	403	3	homeostasis	homeostasis	NOUN
gs-3446	403	4	is	be	AUX
gs-3446	403	5	maintained	maintain	VERB
gs-3446	403	6	through	through	ADP
gs-3446	403	7	complex	complex	ADJ
gs-3446	403	8	regulatory	regulatory	ADJ
gs-3446	403	9	mechanisms	mechanism	NOUN
gs-3446	403	10	involving	involve	VERB
gs-3446	403	11	intrinsic	intrinsic	ADJ
gs-3446	403	12	(	(	PUNCT
gs-3446	403	13	genetic	genetic	ADJ
gs-3446	403	14	and	and	CCONJ
gs-3446	403	15	epigenetic	epigenetic	ADJ
gs-3446	403	16	)	)	PUNCT
gs-3446	403	17	and	and	CCONJ
gs-3446	403	18	extrinsic	extrinsic	ADJ
gs-3446	403	19	(	(	PUNCT
gs-3446	403	20	microenvironmental	microenvironmental	ADJ
gs-3446	403	21	and	and	CCONJ
gs-3446	403	22	systemic	systemic	ADJ
gs-3446	403	23	)	)	PUNCT
gs-3446	403	24	factors	factor	NOUN
gs-3446	403	25	:	:	PUNCT
gs-3446	403	26	●	●	NUM
gs-3446	403	27	intrinsic	intrinsic	ADJ
gs-3446	403	28	regulation	regulation	NOUN
gs-3446	403	29	:	:	PUNCT
gs-3446	403	30	gene	gene	NOUN
gs-3446	403	31	expression	expression	NOUN
gs-3446	403	32	networks	network	NOUN
gs-3446	403	33	,	,	PUNCT
gs-3446	403	34	epigenetic	epigenetic	ADJ
gs-3446	403	35	modifications	modification	NOUN
gs-3446	403	36	,	,	PUNCT
gs-3446	403	37	metabolic	metabolic	NOUN
gs-3446	403	38	status	status	NOUN
gs-3446	403	39	,	,	PUNCT
gs-3446	403	40	and	and	CCONJ
gs-3446	403	41	cell	cell	NOUN
gs-3446	403	42	cycle	cycle	NOUN
gs-3446	403	43	control	control	NOUN
gs-3446	403	44	dictate	dictate	VERB
gs-3446	403	45	stem	stem	NOUN
gs-3446	403	46	cell	cell	NOUN
gs-3446	403	47	fate	fate	NOUN
gs-3446	403	48	.	.	PUNCT
gs-3446	404	1	key	key	ADJ
gs-3446	404	2	transcription	transcription	NOUN
gs-3446	404	3	factors	factor	NOUN
gs-3446	404	4	such	such	ADJ
gs-3446	404	5	as	as	ADP
gs-3446	404	6	oct4	oct4	NOUN
gs-3446	404	7	,	,	PUNCT
gs-3446	404	8	sox2	sox2	NOUN
gs-3446	404	9	,	,	PUNCT
gs-3446	404	10	and	and	CCONJ
gs-3446	404	11	nanog	nanog	PROPN
gs-3446	404	12	in	in	ADP
gs-3446	404	13	pluripotent	pluripotent	ADJ
gs-3446	404	14	stem	stem	NOUN
gs-3446	404	15	cells	cell	NOUN
gs-3446	404	16	maintain	maintain	VERB
gs-3446	404	17	their	their	PRON
gs-3446	404	18	undifferentiated	undifferentiated	ADJ
gs-3446	404	19	state	state	NOUN
gs-3446	404	20	,	,	PUNCT
gs-3446	404	21	while	while	SCONJ
gs-3446	404	22	lineage	lineage	NOUN
gs-3446	404	23	-	-	PUNCT
gs-3446	404	24	specific	specific	ADJ
gs-3446	404	25	regulators	regulator	NOUN
gs-3446	404	26	guide	guide	VERB
gs-3446	404	27	differentiation	differentiation	NOUN
gs-3446	404	28	.	.	PUNCT
gs-3446	405	1	●	●	PUNCT
gs-3446	405	2	extrinsic	extrinsic	ADJ
gs-3446	405	3	regulation	regulation	NOUN
gs-3446	405	4	:	:	PUNCT
gs-3446	405	5	the	the	DET
gs-3446	405	6	stem	stem	NOUN
gs-3446	405	7	cell	cell	NOUN
gs-3446	405	8	niche	niche	NOUN
gs-3446	405	9	,	,	PUNCT
gs-3446	405	10	a	a	DET
gs-3446	405	11	specialized	specialized	ADJ
gs-3446	405	12	microenvironment	microenvironment	NOUN
gs-3446	405	13	,	,	PUNCT
gs-3446	405	14	provides	provide	VERB
gs-3446	405	15	biochemical	biochemical	ADJ
gs-3446	405	16	and	and	CCONJ
gs-3446	405	17	biophysical	biophysical	ADJ
gs-3446	405	18	cues	cue	NOUN
gs-3446	405	19	that	that	PRON
gs-3446	405	20	sustain	sustain	VERB
gs-3446	405	21	stem	stem	NOUN
gs-3446	405	22	cells	cell	NOUN
gs-3446	405	23	.	.	PUNCT
gs-3446	406	1	factors	factor	NOUN
gs-3446	406	2	such	such	ADJ
gs-3446	406	3	as	as	ADP
gs-3446	406	4	wnt	wnt	NOUN
gs-3446	406	5	,	,	PUNCT
gs-3446	406	6	notch	notch	NOUN
gs-3446	406	7	,	,	PUNCT
gs-3446	406	8	bmp	bmp	NOUN
gs-3446	406	9	,	,	PUNCT
gs-3446	406	10	and	and	CCONJ
gs-3446	406	11	hedgehog	hedgehog	NOUN
gs-3446	406	12	signaling	signal	VERB
gs-3446	406	13	pathways	pathway	NOUN
gs-3446	406	14	regulate	regulate	VERB
gs-3446	406	15	proliferation	proliferation	NOUN
gs-3446	406	16	,	,	PUNCT
gs-3446	406	17	differentiation	differentiation	NOUN
gs-3446	406	18	,	,	PUNCT
gs-3446	406	19	and	and	CCONJ
gs-3446	406	20	quiescence	quiescence	NOUN
gs-3446	406	21	.	.	PUNCT
gs-3446	407	1	additionally	additionally	ADV
gs-3446	407	2	,	,	PUNCT
gs-3446	407	3	systemic	systemic	ADJ
gs-3446	407	4	signals	signal	NOUN
gs-3446	407	5	like	like	ADP
gs-3446	407	6	hormones	hormone	NOUN
gs-3446	407	7	,	,	PUNCT
gs-3446	407	8	inflammation	inflammation	NOUN
gs-3446	407	9	,	,	PUNCT
gs-3446	407	10	and	and	CCONJ
gs-3446	407	11	aging	age	VERB
gs-3446	407	12	-	-	PUNCT
gs-3446	407	13	related	relate	VERB
gs-3446	407	14	changes	change	NOUN
gs-3446	407	15	influence	influence	NOUN
gs-3446	407	16	stem	stem	NOUN
gs-3446	407	17	cell	cell	NOUN
gs-3446	407	18	behavior	behavior	NOUN
gs-3446	407	19	.	.	PUNCT
gs-3446	408	1	disruptions	disruption	NOUN
gs-3446	408	2	in	in	ADP
gs-3446	408	3	stem	stem	NOUN
gs-3446	408	4	cell	cell	NOUN
gs-3446	408	5	homeostasis	homeostasis	NOUN
gs-3446	408	6	contribute	contribute	NOUN
gs-3446	408	7	to	to	ADP
gs-3446	408	8	various	various	ADJ
gs-3446	408	9	pathological	pathological	ADJ
gs-3446	408	10	conditions	condition	NOUN
gs-3446	408	11	:	:	PUNCT
gs-3446	408	12	●	●	PUNCT
gs-3446	408	13	aging	aging	NOUN
gs-3446	408	14	:	:	PUNCT
gs-3446	408	15	a	a	DET
gs-3446	408	16	decline	decline	NOUN
gs-3446	408	17	in	in	ADP
gs-3446	408	18	stem	stem	NOUN
gs-3446	408	19	cell	cell	NOUN
gs-3446	408	20	function	function	NOUN
gs-3446	408	21	leads	lead	VERB
gs-3446	408	22	to	to	ADP
gs-3446	408	23	impaired	impaired	ADJ
gs-3446	408	24	tissue	tissue	NOUN
gs-3446	408	25	regeneration	regeneration	NOUN
gs-3446	408	26	and	and	CCONJ
gs-3446	408	27	increased	increase	VERB
gs-3446	408	28	susceptibility	susceptibility	NOUN
gs-3446	408	29	to	to	ADP
gs-3446	408	30	degenerative	degenerative	ADJ
gs-3446	408	31	diseases	disease	NOUN
gs-3446	408	32	.	.	PUNCT
gs-3446	409	1	●	●	PUNCT
gs-3446	409	2	cancer	cancer	NOUN
gs-3446	409	3	:	:	PUNCT
gs-3446	409	4	dysregulation	dysregulation	NOUN
gs-3446	409	5	of	of	ADP
gs-3446	409	6	self	self	NOUN
gs-3446	409	7	-	-	PUNCT
gs-3446	409	8	renewal	renewal	NOUN
gs-3446	409	9	mechanisms	mechanism	NOUN
gs-3446	409	10	can	can	AUX
gs-3446	409	11	result	result	VERB
gs-3446	409	12	in	in	ADP
gs-3446	409	13	uncontrolled	uncontrolled	ADJ
gs-3446	409	14	proliferation	proliferation	NOUN
gs-3446	409	15	and	and	CCONJ
gs-3446	409	16	tumor	tumor	NOUN
gs-3446	409	17	formation	formation	NOUN
gs-3446	409	18	,	,	PUNCT
gs-3446	409	19	often	often	ADV
gs-3446	409	20	driven	drive	VERB
gs-3446	409	21	by	by	ADP
gs-3446	409	22	cancer	cancer	NOUN
gs-3446	409	23	stem	stem	NOUN
gs-3446	409	24	cells	cell	NOUN
gs-3446	409	25	.	.	PUNCT
gs-3446	410	1	georgian	georgian	ADJ
gs-3446	410	2	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3446	410	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	410	4	ტ.	ტ.	VERB
gs-3446	410	5	7	7	NUM
gs-3446	410	6	n	n	PRON
gs-3446	410	7	1	1	NUM
gs-3446	410	8	,	,	PUNCT
gs-3446	410	9	2025	2025	NUM
gs-3446	410	10	296	296	NUM
gs-3446	410	11	●	●	NUM
gs-3446	410	12	tissue	tissue	NOUN
gs-3446	410	13	degeneration	degeneration	NOUN
gs-3446	410	14	:	:	PUNCT
gs-3446	410	15	loss	loss	NOUN
gs-3446	410	16	of	of	ADP
gs-3446	410	17	proper	proper	ADJ
gs-3446	410	18	stem	stem	NOUN
gs-3446	410	19	cell	cell	NOUN
gs-3446	410	20	activity	activity	NOUN
gs-3446	410	21	contributes	contribute	VERB
gs-3446	410	22	to	to	ADP
gs-3446	410	23	conditions	condition	NOUN
gs-3446	410	24	such	such	ADJ
gs-3446	410	25	as	as	ADP
gs-3446	410	26	neurodegenerative	neurodegenerative	ADJ
gs-3446	410	27	diseases	disease	NOUN
gs-3446	410	28	,	,	PUNCT
gs-3446	410	29	osteoporosis	osteoporosis	NOUN
gs-3446	410	30	,	,	PUNCT
gs-3446	410	31	and	and	CCONJ
gs-3446	410	32	muscle	muscle	NOUN
gs-3446	410	33	atrophy	atrophy	NOUN
gs-3446	410	34	(	(	PUNCT
gs-3446	410	35	aphkhazava	aphkhazava	NOUN
gs-3446	410	36	et	et	PROPN
gs-3446	410	37	al	al	PROPN
gs-3446	410	38	.	.	PROPN
gs-3446	410	39	2024	2024	NUM
gs-3446	410	40	)	)	PUNCT
gs-3446	410	41	.	.	PUNCT
gs-3446	411	1	recent	recent	ADJ
gs-3446	411	2	advancements	advancement	NOUN
gs-3446	411	3	in	in	ADP
gs-3446	411	4	stem	stem	NOUN
gs-3446	411	5	cell	cell	NOUN
gs-3446	411	6	research	research	NOUN
gs-3446	411	7	and	and	CCONJ
gs-3446	411	8	regenerative	regenerative	ADJ
gs-3446	411	9	medicine	medicine	NOUN
gs-3446	411	10	aim	aim	VERB
gs-3446	411	11	to	to	PART
gs-3446	411	12	manipulate	manipulate	VERB
gs-3446	411	13	stem	stem	NOUN
gs-3446	411	14	cell	cell	NOUN
gs-3446	411	15	homeostasis	homeostasis	NOUN
gs-3446	411	16	for	for	ADP
gs-3446	411	17	therapeutic	therapeutic	ADJ
gs-3446	411	18	purposes	purpose	NOUN
gs-3446	411	19	.	.	PUNCT
gs-3446	412	1	strategies	strategy	NOUN
gs-3446	412	2	such	such	ADJ
gs-3446	412	3	as	as	ADP
gs-3446	412	4	stem	stem	NOUN
gs-3446	412	5	cell	cell	NOUN
gs-3446	412	6	transplantation	transplantation	NOUN
gs-3446	412	7	,	,	PUNCT
gs-3446	412	8	gene	gene	NOUN
gs-3446	412	9	editing	editing	NOUN
gs-3446	412	10	,	,	PUNCT
gs-3446	412	11	and	and	CCONJ
gs-3446	412	12	tissue	tissue	NOUN
gs-3446	412	13	engineering	engineering	NOUN
gs-3446	412	14	hold	hold	VERB
gs-3446	412	15	promise	promise	NOUN
gs-3446	412	16	for	for	ADP
gs-3446	412	17	treating	treat	VERB
gs-3446	412	18	degenerative	degenerative	ADJ
gs-3446	412	19	diseases	disease	NOUN
gs-3446	412	20	,	,	PUNCT
gs-3446	412	21	injuries	injury	NOUN
gs-3446	412	22	,	,	PUNCT
gs-3446	412	23	and	and	CCONJ
gs-3446	412	24	age	age	NOUN
gs-3446	412	25	-	-	PUNCT
gs-3446	412	26	related	relate	VERB
gs-3446	412	27	disorders	disorder	NOUN
gs-3446	412	28	.	.	PUNCT
gs-3446	413	1	understanding	understand	VERB
gs-3446	413	2	the	the	DET
gs-3446	413	3	fundamental	fundamental	ADJ
gs-3446	413	4	principles	principle	NOUN
gs-3446	413	5	of	of	ADP
gs-3446	413	6	stem	stem	NOUN
gs-3446	413	7	cell	cell	NOUN
gs-3446	413	8	homeostasis	homeostasis	NOUN
gs-3446	413	9	is	be	AUX
gs-3446	413	10	essential	essential	ADJ
gs-3446	413	11	for	for	ADP
gs-3446	413	12	harnessing	harness	VERB
gs-3446	413	13	their	their	PRON
gs-3446	413	14	full	full	ADJ
gs-3446	413	15	potential	potential	NOUN
gs-3446	413	16	in	in	ADP
gs-3446	413	17	biomedical	biomedical	ADJ
gs-3446	413	18	applications	application	NOUN
gs-3446	413	19	.	.	PUNCT
gs-3446	414	1	stem	stem	NOUN
gs-3446	414	2	cells	cell	NOUN
gs-3446	414	3	are	be	AUX
gs-3446	414	4	essential	essential	ADJ
gs-3446	414	5	for	for	ADP
gs-3446	414	6	maintaining	maintain	VERB
gs-3446	414	7	tissue	tissue	NOUN
gs-3446	414	8	integrity	integrity	NOUN
gs-3446	414	9	and	and	CCONJ
gs-3446	414	10	enabling	enable	VERB
gs-3446	414	11	regeneration	regeneration	NOUN
gs-3446	414	12	throughout	throughout	ADP
gs-3446	414	13	an	an	DET
gs-3446	414	14	organism	organism	NOUN
gs-3446	414	15	's	's	PART
gs-3446	414	16	lifespan	lifespan	NOUN
gs-3446	414	17	.	.	PUNCT
gs-3446	415	1	their	their	PRON
gs-3446	415	2	ability	ability	NOUN
gs-3446	415	3	to	to	PART
gs-3446	415	4	self	self	NOUN
gs-3446	415	5	-	-	PUNCT
gs-3446	415	6	renew	renew	VERB
gs-3446	415	7	and	and	CCONJ
gs-3446	415	8	differentiate	differentiate	VERB
gs-3446	415	9	into	into	ADP
gs-3446	415	10	specialized	specialized	ADJ
gs-3446	415	11	cell	cell	NOUN
gs-3446	415	12	types	type	NOUN
gs-3446	415	13	is	be	AUX
gs-3446	415	14	tightly	tightly	ADV
gs-3446	415	15	regulated	regulate	VERB
gs-3446	415	16	to	to	PART
gs-3446	415	17	prevent	prevent	VERB
gs-3446	415	18	depletion	depletion	NOUN
gs-3446	415	19	or	or	CCONJ
gs-3446	415	20	uncontrolled	uncontrolled	ADJ
gs-3446	415	21	expansion	expansion	NOUN
gs-3446	415	22	.	.	PUNCT
gs-3446	416	1	this	this	DET
gs-3446	416	2	balance	balance	NOUN
gs-3446	416	3	,	,	PUNCT
gs-3446	416	4	known	know	VERB
gs-3446	416	5	as	as	ADP
gs-3446	416	6	stem	stem	NOUN
gs-3446	416	7	cell	cell	NOUN
gs-3446	416	8	homeostasis	homeostasis	NOUN
gs-3446	416	9	,	,	PUNCT
gs-3446	416	10	is	be	AUX
gs-3446	416	11	crucial	crucial	ADJ
gs-3446	416	12	for	for	ADP
gs-3446	416	13	sustaining	sustain	VERB
gs-3446	416	14	tissue	tissue	NOUN
gs-3446	416	15	function	function	NOUN
gs-3446	416	16	and	and	CCONJ
gs-3446	416	17	preventing	prevent	VERB
gs-3446	416	18	diseases	disease	NOUN
gs-3446	416	19	such	such	ADJ
gs-3446	416	20	as	as	ADP
gs-3446	416	21	cancer	cancer	NOUN
gs-3446	416	22	and	and	CCONJ
gs-3446	416	23	degenerative	degenerative	ADJ
gs-3446	416	24	disorders	disorder	NOUN
gs-3446	416	25	.	.	PUNCT
gs-3446	417	1	types	type	NOUN
gs-3446	417	2	of	of	ADP
gs-3446	417	3	stem	stem	NOUN
gs-3446	417	4	cells	cell	NOUN
gs-3446	417	5	and	and	CCONJ
gs-3446	417	6	their	their	PRON
gs-3446	417	7	role	role	NOUN
gs-3446	417	8	in	in	ADP
gs-3446	417	9	homeostasis	homeostasis	NOUN
gs-3446	417	10	stem	stem	NOUN
gs-3446	417	11	cells	cell	NOUN
gs-3446	417	12	are	be	AUX
gs-3446	417	13	broadly	broadly	ADV
gs-3446	417	14	categorized	categorize	VERB
gs-3446	417	15	into	into	ADP
gs-3446	417	16	embryonic	embryonic	ADJ
gs-3446	417	17	stem	stem	NOUN
gs-3446	417	18	cells	cell	NOUN
gs-3446	417	19	(	(	PUNCT
gs-3446	417	20	escs	esc	NOUN
gs-3446	417	21	)	)	PUNCT
gs-3446	417	22	and	and	CCONJ
gs-3446	417	23	adult	adult	NOUN
gs-3446	417	24	(	(	PUNCT
gs-3446	417	25	somatic	somatic	ADJ
gs-3446	417	26	)	)	PUNCT
gs-3446	417	27	stem	stem	NOUN
gs-3446	417	28	cells	cell	NOUN
gs-3446	417	29	,	,	PUNCT
gs-3446	417	30	each	each	PRON
gs-3446	417	31	with	with	ADP
gs-3446	417	32	distinct	distinct	ADJ
gs-3446	417	33	roles	role	NOUN
gs-3446	417	34	in	in	ADP
gs-3446	417	35	development	development	NOUN
gs-3446	417	36	and	and	CCONJ
gs-3446	417	37	tissue	tissue	NOUN
gs-3446	417	38	maintenance	maintenance	NOUN
gs-3446	417	39	:	:	PUNCT
gs-3446	417	40	1	1	X
gs-3446	417	41	.	.	X
gs-3446	417	42	embryonic	embryonic	ADJ
gs-3446	417	43	stem	stem	NOUN
gs-3446	417	44	cells	cell	NOUN
gs-3446	417	45	(	(	PUNCT
gs-3446	417	46	escs	esc	NOUN
gs-3446	417	47	):	):	PUNCT
gs-3446	417	48	○	○	PROPN
gs-3446	417	49	derived	derive	VERB
gs-3446	417	50	from	from	ADP
gs-3446	417	51	the	the	DET
gs-3446	417	52	inner	inner	ADJ
gs-3446	417	53	cell	cell	NOUN
gs-3446	417	54	mass	mass	NOUN
gs-3446	417	55	of	of	ADP
gs-3446	417	56	the	the	DET
gs-3446	417	57	blastocyst	blastocyst	NOUN
gs-3446	417	58	,	,	PUNCT
gs-3446	417	59	escs	esc	NOUN
gs-3446	417	60	possess	possess	VERB
gs-3446	417	61	pluripotency	pluripotency	NOUN
gs-3446	417	62	,	,	PUNCT
gs-3446	417	63	meaning	mean	VERB
gs-3446	417	64	they	they	PRON
gs-3446	417	65	can	can	AUX
gs-3446	417	66	differentiate	differentiate	VERB
gs-3446	417	67	into	into	ADP
gs-3446	417	68	all	all	DET
gs-3446	417	69	three	three	NUM
gs-3446	417	70	germ	germ	NOUN
gs-3446	417	71	layers	layer	NOUN
gs-3446	417	72	(	(	PUNCT
gs-3446	417	73	ectoderm	ectoderm	NOUN
gs-3446	417	74	,	,	PUNCT
gs-3446	417	75	mesoderm	mesoderm	NOUN
gs-3446	417	76	,	,	PUNCT
gs-3446	417	77	and	and	CCONJ
gs-3446	417	78	endoderm	endoderm	NOUN
gs-3446	417	79	)	)	PUNCT
gs-3446	417	80	.	.	PUNCT
gs-3446	418	1	○	○	PROPN
gs-3446	418	2	during	during	ADP
gs-3446	418	3	embryogenesis	embryogenesis	NOUN
gs-3446	418	4	,	,	PUNCT
gs-3446	418	5	precise	precise	ADJ
gs-3446	418	6	signaling	signal	VERB
gs-3446	418	7	pathways	pathway	NOUN
gs-3446	418	8	(	(	PUNCT
gs-3446	418	9	e.g.	e.g.	ADV
gs-3446	418	10	,	,	PUNCT
gs-3446	418	11	wnt	wnt	PROPN
gs-3446	418	12	,	,	PUNCT
gs-3446	418	13	bmp	bmp	PROPN
gs-3446	418	14	,	,	PUNCT
gs-3446	418	15	and	and	CCONJ
gs-3446	418	16	notch	notch	ADJ
gs-3446	418	17	)	)	PUNCT
gs-3446	418	18	regulate	regulate	VERB
gs-3446	418	19	esc	esc	NOUN
gs-3446	418	20	proliferation	proliferation	NOUN
gs-3446	418	21	and	and	CCONJ
gs-3446	418	22	differentiation	differentiation	NOUN
gs-3446	418	23	to	to	PART
gs-3446	418	24	form	form	VERB
gs-3446	418	25	functional	functional	ADJ
gs-3446	418	26	tissues	tissue	NOUN
gs-3446	418	27	.	.	PUNCT
gs-3446	419	1	2	2	X
gs-3446	419	2	.	.	X
gs-3446	419	3	adult	adult	NOUN
gs-3446	419	4	stem	stem	NOUN
gs-3446	419	5	cells	cell	NOUN
gs-3446	419	6	(	(	PUNCT
gs-3446	419	7	ascs	asc	NOUN
gs-3446	419	8	):	):	PUNCT
gs-3446	419	9	○	○	ADJ
gs-3446	419	10	these	these	DET
gs-3446	419	11	multipotent	multipotent	NOUN
gs-3446	419	12	cells	cell	NOUN
gs-3446	419	13	reside	reside	VERB
gs-3446	419	14	in	in	ADP
gs-3446	419	15	specific	specific	ADJ
gs-3446	419	16	stem	stem	NOUN
gs-3446	419	17	cell	cell	NOUN
gs-3446	419	18	niches	niche	NOUN
gs-3446	419	19	and	and	CCONJ
gs-3446	419	20	contribute	contribute	VERB
gs-3446	419	21	to	to	ADP
gs-3446	419	22	tissue	tissue	NOUN
gs-3446	419	23	maintenance	maintenance	NOUN
gs-3446	419	24	and	and	CCONJ
gs-3446	419	25	repair	repair	NOUN
gs-3446	419	26	throughout	throughout	ADP
gs-3446	419	27	life	life	NOUN
gs-3446	419	28	.	.	PUNCT
gs-3446	420	1	○	○	ADJ
gs-3446	420	2	examples	example	NOUN
gs-3446	420	3	of	of	ADP
gs-3446	420	4	ascs	asc	NOUN
gs-3446	420	5	include	include	VERB
gs-3446	420	6	:	:	PUNCT
gs-3446	420	7	■	■	PUNCT
gs-3446	420	8	hematopoietic	hematopoietic	ADJ
gs-3446	420	9	stem	stem	NOUN
gs-3446	420	10	cells	cell	NOUN
gs-3446	420	11	(	(	PUNCT
gs-3446	420	12	hscs	hsc	NOUN
gs-3446	420	13	):	):	PUNCT
gs-3446	420	14	maintain	maintain	VERB
gs-3446	420	15	blood	blood	NOUN
gs-3446	420	16	cell	cell	NOUN
gs-3446	420	17	production	production	NOUN
gs-3446	420	18	in	in	ADP
gs-3446	420	19	the	the	DET
gs-3446	420	20	bone	bone	NOUN
gs-3446	420	21	marrow	marrow	NOUN
gs-3446	420	22	.	.	PUNCT
gs-3446	421	1	■	■	PUNCT
gs-3446	421	2	mesenchymal	mesenchymal	ADJ
gs-3446	421	3	stem	stem	NOUN
gs-3446	421	4	cells	cell	NOUN
gs-3446	421	5	(	(	PUNCT
gs-3446	421	6	mscs	msc	NOUN
gs-3446	421	7	):	):	PUNCT
gs-3446	421	8	differentiate	differentiate	VERB
gs-3446	421	9	into	into	ADP
gs-3446	421	10	bone	bone	NOUN
gs-3446	421	11	,	,	PUNCT
gs-3446	421	12	cartilage	cartilage	NOUN
gs-3446	421	13	,	,	PUNCT
gs-3446	421	14	and	and	CCONJ
gs-3446	421	15	fat	fat	ADJ
gs-3446	421	16	cells	cell	NOUN
gs-3446	421	17	.	.	PUNCT
gs-3446	422	1	■	■	PUNCT
gs-3446	422	2	neural	neural	ADJ
gs-3446	422	3	stem	stem	NOUN
gs-3446	422	4	cells	cell	NOUN
gs-3446	422	5	(	(	PUNCT
gs-3446	422	6	nscs	nsc	VERB
gs-3446	422	7	):	):	PUNCT
gs-3446	422	8	generate	generate	VERB
gs-3446	422	9	neurons	neuron	NOUN
gs-3446	422	10	and	and	CCONJ
gs-3446	422	11	glial	glial	ADJ
gs-3446	422	12	cells	cell	NOUN
gs-3446	422	13	in	in	ADP
gs-3446	422	14	the	the	DET
gs-3446	422	15	brain	brain	NOUN
gs-3446	422	16	.	.	PUNCT
gs-3446	423	1	■	■	PUNCT
gs-3446	423	2	epithelial	epithelial	ADJ
gs-3446	423	3	stem	stem	NOUN
gs-3446	423	4	cells	cell	NOUN
gs-3446	423	5	:	:	PUNCT
gs-3446	423	6	regenerate	regenerate	ADJ
gs-3446	423	7	skin	skin	NOUN
gs-3446	423	8	,	,	PUNCT
gs-3446	423	9	intestines	intestine	NOUN
gs-3446	423	10	,	,	PUNCT
gs-3446	423	11	and	and	CCONJ
gs-3446	423	12	other	other	ADJ
gs-3446	423	13	epithelial	epithelial	ADJ
gs-3446	423	14	tissues	tissue	NOUN
gs-3446	423	15	.	.	PUNCT
gs-3446	424	1	regulation	regulation	NOUN
gs-3446	424	2	of	of	ADP
gs-3446	424	3	stem	stem	NOUN
gs-3446	424	4	cell	cell	NOUN
gs-3446	424	5	homeostasis	homeostasis	NOUN
gs-3446	424	6	stem	stem	NOUN
gs-3446	424	7	cell	cell	NOUN
gs-3446	424	8	homeostasis	homeostasis	NOUN
gs-3446	424	9	is	be	AUX
gs-3446	424	10	maintained	maintain	VERB
gs-3446	424	11	by	by	ADP
gs-3446	424	12	a	a	DET
gs-3446	424	13	complex	complex	ADJ
gs-3446	424	14	interplay	interplay	NOUN
gs-3446	424	15	of	of	ADP
gs-3446	424	16	intrinsic	intrinsic	ADJ
gs-3446	424	17	and	and	CCONJ
gs-3446	424	18	extrinsic	extrinsic	ADJ
gs-3446	424	19	factors	factor	NOUN
gs-3446	424	20	:	:	PUNCT
gs-3446	424	21	intrinsic	intrinsic	ADJ
gs-3446	424	22	regulation	regulation	NOUN
gs-3446	424	23	these	these	PRON
gs-3446	424	24	are	be	AUX
gs-3446	424	25	cell	cell	NOUN
gs-3446	424	26	-	-	PUNCT
gs-3446	424	27	autonomous	autonomous	ADJ
gs-3446	424	28	mechanisms	mechanism	NOUN
gs-3446	424	29	that	that	PRON
gs-3446	424	30	control	control	VERB
gs-3446	424	31	stem	stem	NOUN
gs-3446	424	32	cell	cell	NOUN
gs-3446	424	33	function	function	NOUN
gs-3446	424	34	:	:	PUNCT
gs-3446	424	35	georgian	georgian	ADJ
gs-3446	424	36	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3446	424	37	მეცნიერები	მეცნიერები	NOUN
gs-3446	424	38	ტ.	ტ.	VERB
gs-3446	424	39	7	7	NUM
gs-3446	424	40	n	n	PRON
gs-3446	424	41	1	1	NUM
gs-3446	424	42	,	,	PUNCT
gs-3446	424	43	2025	2025	NUM
gs-3446	424	44	297	297	NUM
gs-3446	424	45	●	●	NUM
gs-3446	424	46	transcription	transcription	NOUN
gs-3446	424	47	factors	factor	NOUN
gs-3446	424	48	:	:	PUNCT
gs-3446	424	49	master	master	NOUN
gs-3446	424	50	regulators	regulator	NOUN
gs-3446	424	51	such	such	ADJ
gs-3446	424	52	as	as	ADP
gs-3446	424	53	oct4	oct4	NOUN
gs-3446	424	54	,	,	PUNCT
gs-3446	424	55	sox2	sox2	NOUN
gs-3446	424	56	,	,	PUNCT
gs-3446	424	57	and	and	CCONJ
gs-3446	424	58	nanog	nanog	PROPN
gs-3446	424	59	maintain	maintain	VERB
gs-3446	424	60	pluripotency	pluripotency	NOUN
gs-3446	424	61	in	in	ADP
gs-3446	424	62	escs	esc	NOUN
gs-3446	424	63	,	,	PUNCT
gs-3446	424	64	while	while	SCONJ
gs-3446	424	65	tissue	tissue	NOUN
gs-3446	424	66	-	-	PUNCT
gs-3446	424	67	specific	specific	ADJ
gs-3446	424	68	factors	factor	NOUN
gs-3446	424	69	(	(	PUNCT
gs-3446	424	70	e.g.	e.g.	ADV
gs-3446	424	71	,	,	PUNCT
gs-3446	424	72	gata2	gata2	NOUN
gs-3446	424	73	in	in	ADP
gs-3446	424	74	hscs	hsc	NOUN
gs-3446	424	75	,	,	PUNCT
gs-3446	424	76	sox9	sox9	PROPN
gs-3446	424	77	in	in	ADP
gs-3446	424	78	nscs	nscs	PROPN
gs-3446	424	79	)	)	PUNCT
gs-3446	424	80	drive	drive	ADJ
gs-3446	424	81	lineage	lineage	NOUN
gs-3446	424	82	commitment	commitment	NOUN
gs-3446	424	83	.	.	PUNCT
gs-3446	425	1	●	●	PUNCT
gs-3446	425	2	epigenetic	epigenetic	ADJ
gs-3446	425	3	modifications	modification	NOUN
gs-3446	425	4	:	:	PUNCT
gs-3446	425	5	dna	dna	PROPN
gs-3446	425	6	methylation	methylation	NOUN
gs-3446	425	7	,	,	PUNCT
gs-3446	425	8	histone	histone	NOUN
gs-3446	425	9	modifications	modification	NOUN
gs-3446	425	10	,	,	PUNCT
gs-3446	425	11	and	and	CCONJ
gs-3446	425	12	non	non	ADJ
gs-3446	425	13	-	-	ADJ
gs-3446	425	14	coding	coding	ADJ
gs-3446	425	15	rnas	rna	NOUN
gs-3446	425	16	influence	influence	NOUN
gs-3446	425	17	gene	gene	NOUN
gs-3446	425	18	expression	expression	NOUN
gs-3446	425	19	and	and	CCONJ
gs-3446	425	20	cell	cell	NOUN
gs-3446	425	21	fate	fate	NOUN
gs-3446	425	22	decisions	decision	NOUN
gs-3446	425	23	.	.	PUNCT
gs-3446	426	1	●	●	NUM
gs-3446	426	2	cell	cell	NOUN
gs-3446	426	3	cycle	cycle	NOUN
gs-3446	426	4	control	control	NOUN
gs-3446	426	5	:	:	PUNCT
gs-3446	426	6	quiescence	quiescence	NOUN
gs-3446	426	7	,	,	PUNCT
gs-3446	426	8	an	an	DET
gs-3446	426	9	essential	essential	ADJ
gs-3446	426	10	property	property	NOUN
gs-3446	426	11	of	of	ADP
gs-3446	426	12	adult	adult	NOUN
gs-3446	426	13	stem	stem	NOUN
gs-3446	426	14	cells	cell	NOUN
gs-3446	426	15	,	,	PUNCT
gs-3446	426	16	is	be	AUX
gs-3446	426	17	regulated	regulate	VERB
gs-3446	426	18	by	by	ADP
gs-3446	426	19	cyclins	cyclin	NOUN
gs-3446	426	20	,	,	PUNCT
gs-3446	426	21	cdks	cdks	NOUN
gs-3446	426	22	,	,	PUNCT
gs-3446	426	23	and	and	CCONJ
gs-3446	426	24	tumor	tumor	NOUN
gs-3446	426	25	suppressors	suppressor	NOUN
gs-3446	426	26	like	like	ADP
gs-3446	426	27	p53	p53	NOUN
gs-3446	426	28	and	and	CCONJ
gs-3446	426	29	rb1	rb1	PROPN
gs-3446	426	30	,	,	PUNCT
gs-3446	426	31	ensuring	ensure	VERB
gs-3446	426	32	a	a	DET
gs-3446	426	33	balance	balance	NOUN
gs-3446	426	34	between	between	ADP
gs-3446	426	35	proliferation	proliferation	NOUN
gs-3446	426	36	and	and	CCONJ
gs-3446	426	37	differentiation	differentiation	NOUN
gs-3446	426	38	.	.	PUNCT
gs-3446	427	1	●	●	PUNCT
gs-3446	427	2	metabolic	metabolic	NOUN
gs-3446	427	3	regulation	regulation	NOUN
gs-3446	427	4	:	:	PUNCT
gs-3446	427	5	stem	stem	NOUN
gs-3446	427	6	cells	cell	NOUN
gs-3446	427	7	rely	rely	VERB
gs-3446	427	8	on	on	ADP
gs-3446	427	9	unique	unique	ADJ
gs-3446	427	10	metabolic	metabolic	NOUN
gs-3446	427	11	pathways	pathway	NOUN
gs-3446	427	12	(	(	PUNCT
gs-3446	427	13	e.g.	e.g.	ADV
gs-3446	427	14	,	,	PUNCT
gs-3446	427	15	glycolysis	glycolysis	NOUN
gs-3446	427	16	in	in	ADP
gs-3446	427	17	pluripotent	pluripotent	ADJ
gs-3446	427	18	cells	cell	NOUN
gs-3446	427	19	,	,	PUNCT
gs-3446	427	20	oxidative	oxidative	ADJ
gs-3446	427	21	phosphorylation	phosphorylation	NOUN
gs-3446	427	22	in	in	ADP
gs-3446	427	23	differentiating	differentiate	VERB
gs-3446	427	24	cells	cell	NOUN
gs-3446	427	25	)	)	PUNCT
gs-3446	427	26	to	to	PART
gs-3446	427	27	maintain	maintain	VERB
gs-3446	427	28	their	their	PRON
gs-3446	427	29	function	function	NOUN
gs-3446	427	30	.	.	PUNCT
gs-3446	428	1	extrinsic	extrinsic	ADJ
gs-3446	428	2	regulation	regulation	NOUN
gs-3446	428	3	stem	stem	NOUN
gs-3446	428	4	cell	cell	NOUN
gs-3446	428	5	activity	activity	NOUN
gs-3446	428	6	is	be	AUX
gs-3446	428	7	also	also	ADV
gs-3446	428	8	modulated	modulate	VERB
gs-3446	428	9	by	by	ADP
gs-3446	428	10	signals	signal	NOUN
gs-3446	428	11	from	from	ADP
gs-3446	428	12	the	the	DET
gs-3446	428	13	stem	stem	NOUN
gs-3446	428	14	cell	cell	NOUN
gs-3446	428	15	niche	niche	NOUN
gs-3446	428	16	,	,	PUNCT
gs-3446	428	17	systemic	systemic	ADJ
gs-3446	428	18	factors	factor	NOUN
gs-3446	428	19	,	,	PUNCT
gs-3446	428	20	and	and	CCONJ
gs-3446	428	21	environmental	environmental	ADJ
gs-3446	428	22	influences	influence	NOUN
gs-3446	428	23	:	:	PUNCT
gs-3446	428	24	●	●	NUM
gs-3446	428	25	stem	stem	NOUN
gs-3446	428	26	cell	cell	NOUN
gs-3446	428	27	niches	niche	NOUN
gs-3446	428	28	:	:	PUNCT
gs-3446	428	29	these	these	DET
gs-3446	428	30	microenvironments	microenvironment	NOUN
gs-3446	428	31	provide	provide	VERB
gs-3446	428	32	biochemical	biochemical	ADJ
gs-3446	428	33	and	and	CCONJ
gs-3446	428	34	biophysical	biophysical	ADJ
gs-3446	428	35	cues	cue	NOUN
gs-3446	428	36	to	to	PART
gs-3446	428	37	regulate	regulate	VERB
gs-3446	428	38	stem	stem	NOUN
gs-3446	428	39	cell	cell	NOUN
gs-3446	428	40	fate	fate	NOUN
gs-3446	428	41	.	.	PUNCT
gs-3446	429	1	○	○	ADJ
gs-3446	429	2	example	example	NOUN
gs-3446	429	3	:	:	PUNCT
gs-3446	429	4	the	the	DET
gs-3446	429	5	bone	bone	NOUN
gs-3446	429	6	marrow	marrow	NOUN
gs-3446	429	7	niche	niche	NOUN
gs-3446	429	8	supports	support	VERB
gs-3446	429	9	hematopoietic	hematopoietic	ADJ
gs-3446	429	10	stem	stem	NOUN
gs-3446	429	11	cells	cell	NOUN
gs-3446	429	12	through	through	ADP
gs-3446	429	13	signals	signal	NOUN
gs-3446	429	14	like	like	ADP
gs-3446	429	15	scf	scf	PROPN
gs-3446	429	16	,	,	PUNCT
gs-3446	429	17	cxcl12	cxcl12	ADJ
gs-3446	429	18	,	,	PUNCT
gs-3446	429	19	and	and	CCONJ
gs-3446	429	20	notch	notch	ADJ
gs-3446	429	21	ligands	ligand	NOUN
gs-3446	429	22	.	.	PUNCT
gs-3446	430	1	●	●	PUNCT
gs-3446	430	2	signaling	signal	VERB
gs-3446	430	3	pathways	pathway	NOUN
gs-3446	430	4	:	:	PUNCT
gs-3446	430	5	major	major	ADJ
gs-3446	430	6	pathways	pathway	NOUN
gs-3446	430	7	that	that	PRON
gs-3446	430	8	control	control	VERB
gs-3446	430	9	stem	stem	NOUN
gs-3446	430	10	cell	cell	NOUN
gs-3446	430	11	homeostasis	homeostasis	NOUN
gs-3446	430	12	include	include	NOUN
gs-3446	430	13	:	:	PUNCT
gs-3446	430	14	○	○	PROPN
gs-3446	430	15	wnt	wnt	PROPN
gs-3446	430	16	/	/	SYM
gs-3446	430	17	β	β	NOUN
gs-3446	430	18	-	-	NOUN
gs-3446	430	19	catenin	catenin	NOUN
gs-3446	430	20	:	:	PUNCT
gs-3446	430	21	promotes	promote	VERB
gs-3446	430	22	self	self	NOUN
gs-3446	430	23	-	-	PUNCT
gs-3446	430	24	renewal	renewal	NOUN
gs-3446	430	25	in	in	ADP
gs-3446	430	26	multiple	multiple	ADJ
gs-3446	430	27	stem	stem	NOUN
gs-3446	430	28	cell	cell	NOUN
gs-3446	430	29	types	type	NOUN
gs-3446	430	30	.	.	PUNCT
gs-3446	431	1	○	○	ADJ
gs-3446	431	2	notch	notch	NOUN
gs-3446	431	3	:	:	PUNCT
gs-3446	431	4	maintains	maintain	VERB
gs-3446	431	5	stem	stem	NOUN
gs-3446	431	6	cell	cell	NOUN
gs-3446	431	7	quiescence	quiescence	NOUN
gs-3446	431	8	and	and	CCONJ
gs-3446	431	9	differentiation	differentiation	NOUN
gs-3446	431	10	balance	balance	NOUN
gs-3446	431	11	.	.	PUNCT
gs-3446	432	1	○	○	PROPN
gs-3446	432	2	bmp	bmp	PROPN
gs-3446	432	3	(	(	PUNCT
gs-3446	432	4	bone	bone	NOUN
gs-3446	432	5	morphogenetic	morphogenetic	ADJ
gs-3446	432	6	proteins	protein	NOUN
gs-3446	432	7	):	):	PUNCT
gs-3446	432	8	regulates	regulate	VERB
gs-3446	432	9	differentiation	differentiation	NOUN
gs-3446	432	10	and	and	CCONJ
gs-3446	432	11	lineage	lineage	NOUN
gs-3446	432	12	commitment	commitment	NOUN
gs-3446	432	13	.	.	PUNCT
gs-3446	433	1	○	○	PROPN
gs-3446	433	2	hedgehog	hedgehog	PROPN
gs-3446	433	3	(	(	PUNCT
gs-3446	433	4	hh	hh	PROPN
gs-3446	433	5	):	):	PUNCT
gs-3446	433	6	essential	essential	ADJ
gs-3446	433	7	for	for	ADP
gs-3446	433	8	tissue	tissue	NOUN
gs-3446	433	9	development	development	NOUN
gs-3446	433	10	and	and	CCONJ
gs-3446	433	11	adult	adult	NOUN
gs-3446	433	12	stem	stem	NOUN
gs-3446	433	13	cell	cell	NOUN
gs-3446	433	14	function	function	NOUN
gs-3446	433	15	.	.	PUNCT
gs-3446	434	1	●	●	PUNCT
gs-3446	434	2	systemic	systemic	ADJ
gs-3446	434	3	and	and	CCONJ
gs-3446	434	4	environmental	environmental	ADJ
gs-3446	434	5	factors	factor	NOUN
gs-3446	434	6	:	:	PUNCT
gs-3446	434	7	○	○	ADJ
gs-3446	434	8	hormones	hormone	NOUN
gs-3446	434	9	(	(	PUNCT
gs-3446	434	10	e.g.	e.g.	ADV
gs-3446	434	11	,	,	PUNCT
gs-3446	434	12	insulin	insulin	NOUN
gs-3446	434	13	,	,	PUNCT
gs-3446	434	14	thyroid	thyroid	NOUN
gs-3446	434	15	hormones	hormone	NOUN
gs-3446	434	16	)	)	PUNCT
gs-3446	434	17	influence	influence	NOUN
gs-3446	434	18	stem	stem	NOUN
gs-3446	434	19	cell	cell	NOUN
gs-3446	434	20	metabolism	metabolism	NOUN
gs-3446	434	21	and	and	CCONJ
gs-3446	434	22	proliferation	proliferation	NOUN
gs-3446	434	23	.	.	PUNCT
gs-3446	435	1	○	○	ADJ
gs-3446	435	2	inflammation	inflammation	ADJ
gs-3446	435	3	and	and	CCONJ
gs-3446	435	4	immune	immune	ADJ
gs-3446	435	5	signals	signal	NOUN
gs-3446	435	6	:	:	PUNCT
gs-3446	435	7	chronic	chronic	ADJ
gs-3446	435	8	inflammation	inflammation	NOUN
gs-3446	435	9	can	can	AUX
gs-3446	435	10	disrupt	disrupt	VERB
gs-3446	435	11	stem	stem	NOUN
gs-3446	435	12	cell	cell	NOUN
gs-3446	435	13	function	function	NOUN
gs-3446	435	14	,	,	PUNCT
gs-3446	435	15	contributing	contribute	VERB
gs-3446	435	16	to	to	ADP
gs-3446	435	17	aging	aging	NOUN
gs-3446	435	18	and	and	CCONJ
gs-3446	435	19	disease	disease	NOUN
gs-3446	435	20	.	.	PUNCT
gs-3446	436	1	○	○	ADJ
gs-3446	436	2	aging	aging	NOUN
gs-3446	436	3	:	:	PUNCT
gs-3446	436	4	cellular	cellular	ADJ
gs-3446	436	5	senescence	senescence	NOUN
gs-3446	436	6	and	and	CCONJ
gs-3446	436	7	dna	dna	PROPN
gs-3446	436	8	damage	damage	NOUN
gs-3446	436	9	accumulation	accumulation	NOUN
gs-3446	436	10	impair	impair	NOUN
gs-3446	436	11	stem	stem	NOUN
gs-3446	436	12	cell	cell	NOUN
gs-3446	436	13	homeostasis	homeostasis	NOUN
gs-3446	436	14	over	over	ADP
gs-3446	436	15	time	time	NOUN
gs-3446	436	16	.	.	PUNCT
gs-3446	437	1	disruptions	disruption	NOUN
gs-3446	437	2	in	in	ADP
gs-3446	437	3	stem	stem	NOUN
gs-3446	437	4	cell	cell	NOUN
gs-3446	437	5	homeostasis	homeostasis	NOUN
gs-3446	437	6	and	and	CCONJ
gs-3446	437	7	disease	disease	NOUN
gs-3446	437	8	implications	implication	NOUN
gs-3446	437	9	failure	failure	NOUN
gs-3446	437	10	to	to	PART
gs-3446	437	11	maintain	maintain	VERB
gs-3446	437	12	stem	stem	NOUN
gs-3446	437	13	cell	cell	NOUN
gs-3446	437	14	homeostasis	homeostasis	NOUN
gs-3446	437	15	can	can	AUX
gs-3446	437	16	lead	lead	VERB
gs-3446	437	17	to	to	ADP
gs-3446	437	18	various	various	ADJ
gs-3446	437	19	pathologies	pathology	NOUN
gs-3446	437	20	:	:	PUNCT
gs-3446	437	21	1	1	X
gs-3446	437	22	.	.	X
gs-3446	437	23	aging	aging	NOUN
gs-3446	437	24	and	and	CCONJ
gs-3446	437	25	degeneration	degeneration	NOUN
gs-3446	437	26	:	:	PUNCT
gs-3446	437	27	○	○	ADJ
gs-3446	437	28	reduced	reduce	VERB
gs-3446	437	29	stem	stem	NOUN
gs-3446	437	30	cell	cell	NOUN
gs-3446	437	31	function	function	NOUN
gs-3446	437	32	with	with	ADP
gs-3446	437	33	age	age	NOUN
gs-3446	437	34	leads	lead	VERB
gs-3446	437	35	to	to	ADP
gs-3446	437	36	impaired	impaired	ADJ
gs-3446	437	37	tissue	tissue	NOUN
gs-3446	437	38	repair	repair	NOUN
gs-3446	437	39	,	,	PUNCT
gs-3446	437	40	contributing	contribute	VERB
gs-3446	437	41	to	to	ADP
gs-3446	437	42	neurodegenerative	neurodegenerative	ADJ
gs-3446	437	43	diseases	disease	NOUN
gs-3446	437	44	,	,	PUNCT
gs-3446	437	45	osteoporosis	osteoporosis	NOUN
gs-3446	437	46	,	,	PUNCT
gs-3446	437	47	and	and	CCONJ
gs-3446	437	48	muscle	muscle	NOUN
gs-3446	437	49	atrophy	atrophy	NOUN
gs-3446	437	50	.	.	PUNCT
gs-3446	438	1	georgian	georgian	ADJ
gs-3446	438	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	438	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	438	4	ტ.	ტ.	VERB
gs-3446	438	5	7	7	NUM
gs-3446	438	6	n	n	PRON
gs-3446	438	7	1	1	NUM
gs-3446	438	8	,	,	PUNCT
gs-3446	438	9	2025	2025	NUM
gs-3446	438	10	298	298	NUM
gs-3446	438	11	○	○	ADJ
gs-3446	438	12	example	example	NOUN
gs-3446	438	13	:	:	PUNCT
gs-3446	438	14	aging	age	VERB
gs-3446	438	15	hematopoietic	hematopoietic	ADJ
gs-3446	438	16	stem	stem	NOUN
gs-3446	438	17	cells	cell	NOUN
gs-3446	438	18	show	show	VERB
gs-3446	438	19	biased	biased	ADJ
gs-3446	438	20	differentiation	differentiation	NOUN
gs-3446	438	21	toward	toward	ADP
gs-3446	438	22	myeloid	myeloid	ADJ
gs-3446	438	23	lineage	lineage	NOUN
gs-3446	438	24	,	,	PUNCT
gs-3446	438	25	increasing	increase	VERB
gs-3446	438	26	susceptibility	susceptibility	NOUN
gs-3446	438	27	to	to	ADP
gs-3446	438	28	blood	blood	NOUN
gs-3446	438	29	disorders	disorder	NOUN
gs-3446	438	30	(	(	PUNCT
gs-3446	438	31	aphkhazava	aphkhazava	NOUN
gs-3446	438	32	et	et	PROPN
gs-3446	438	33	al	al	PROPN
gs-3446	438	34	.	.	PROPN
gs-3446	438	35	2024	2024	NUM
gs-3446	438	36	)	)	PUNCT
gs-3446	438	37	.	.	PUNCT
gs-3446	439	1	2	2	X
gs-3446	439	2	.	.	X
gs-3446	439	3	cancer	cancer	NOUN
gs-3446	439	4	and	and	CCONJ
gs-3446	439	5	uncontrolled	uncontrolled	ADJ
gs-3446	439	6	proliferation	proliferation	NOUN
gs-3446	439	7	:	:	PUNCT
gs-3446	439	8	○	○	ADJ
gs-3446	439	9	dysregulated	dysregulated	ADJ
gs-3446	439	10	self	self	NOUN
gs-3446	439	11	-	-	PUNCT
gs-3446	439	12	renewal	renewal	NOUN
gs-3446	439	13	mechanisms	mechanism	NOUN
gs-3446	439	14	can	can	AUX
gs-3446	439	15	lead	lead	VERB
gs-3446	439	16	to	to	ADP
gs-3446	439	17	the	the	DET
gs-3446	439	18	formation	formation	NOUN
gs-3446	439	19	of	of	ADP
gs-3446	439	20	cancer	cancer	NOUN
gs-3446	439	21	stem	stem	NOUN
gs-3446	439	22	cells	cell	NOUN
gs-3446	439	23	(	(	PUNCT
gs-3446	439	24	cscs	cscs	PROPN
gs-3446	439	25	)	)	PUNCT
gs-3446	439	26	,	,	PUNCT
gs-3446	439	27	driving	drive	VERB
gs-3446	439	28	tumor	tumor	NOUN
gs-3446	439	29	growth	growth	NOUN
gs-3446	439	30	and	and	CCONJ
gs-3446	439	31	therapy	therapy	NOUN
gs-3446	439	32	resistance	resistance	NOUN
gs-3446	439	33	.	.	PUNCT
gs-3446	440	1	○	○	ADJ
gs-3446	440	2	example	example	NOUN
gs-3446	440	3	:	:	PUNCT
gs-3446	440	4	leukemia	leukemia	NOUN
gs-3446	440	5	stem	stem	NOUN
gs-3446	440	6	cells	cell	NOUN
gs-3446	440	7	arise	arise	VERB
gs-3446	440	8	from	from	ADP
gs-3446	440	9	mutations	mutation	NOUN
gs-3446	440	10	in	in	ADP
gs-3446	440	11	hsc	hsc	PROPN
gs-3446	440	12	regulatory	regulatory	ADJ
gs-3446	440	13	pathways	pathway	NOUN
gs-3446	440	14	.	.	PUNCT
gs-3446	441	1	3	3	X
gs-3446	441	2	.	.	X
gs-3446	441	3	tissue	tissue	NOUN
gs-3446	441	4	degeneration	degeneration	NOUN
gs-3446	441	5	and	and	CCONJ
gs-3446	441	6	impaired	impaired	ADJ
gs-3446	441	7	regeneration	regeneration	NOUN
gs-3446	441	8	:	:	PUNCT
gs-3446	441	9	○	○	ADJ
gs-3446	441	10	inadequate	inadequate	ADJ
gs-3446	441	11	stem	stem	NOUN
gs-3446	441	12	cell	cell	NOUN
gs-3446	441	13	renewal	renewal	NOUN
gs-3446	441	14	or	or	CCONJ
gs-3446	441	15	excessive	excessive	ADJ
gs-3446	441	16	differentiation	differentiation	NOUN
gs-3446	441	17	results	result	NOUN
gs-3446	441	18	in	in	ADP
gs-3446	441	19	tissue	tissue	NOUN
gs-3446	441	20	dysfunction	dysfunction	NOUN
gs-3446	441	21	.	.	PUNCT
gs-3446	442	1	○	○	ADJ
gs-3446	442	2	example	example	NOUN
gs-3446	442	3	:	:	PUNCT
gs-3446	442	4	neurodegenerative	neurodegenerative	ADJ
gs-3446	442	5	disorders	disorder	NOUN
gs-3446	442	6	like	like	ADP
gs-3446	442	7	parkinson	parkinson	NOUN
gs-3446	442	8	’s	’s	PART
gs-3446	442	9	disease	disease	NOUN
gs-3446	442	10	involve	involve	VERB
gs-3446	442	11	the	the	DET
gs-3446	442	12	depletion	depletion	NOUN
gs-3446	442	13	of	of	ADP
gs-3446	442	14	neural	neural	ADJ
gs-3446	442	15	stem	stem	NOUN
gs-3446	442	16	/	/	SYM
gs-3446	442	17	progenitor	progenitor	NOUN
gs-3446	442	18	cells	cell	NOUN
gs-3446	442	19	.	.	PUNCT
gs-3446	443	1	clinical	clinical	ADJ
gs-3446	443	2	and	and	CCONJ
gs-3446	443	3	therapeutic	therapeutic	ADJ
gs-3446	443	4	implications	implication	NOUN
gs-3446	443	5	advancements	advancement	NOUN
gs-3446	443	6	in	in	ADP
gs-3446	443	7	stem	stem	NOUN
gs-3446	443	8	cell	cell	NOUN
gs-3446	443	9	research	research	NOUN
gs-3446	443	10	aim	aim	VERB
gs-3446	443	11	to	to	PART
gs-3446	443	12	manipulate	manipulate	VERB
gs-3446	443	13	homeostatic	homeostatic	ADJ
gs-3446	443	14	mechanisms	mechanism	NOUN
gs-3446	443	15	for	for	ADP
gs-3446	443	16	therapeutic	therapeutic	ADJ
gs-3446	443	17	applications	application	NOUN
gs-3446	443	18	:	:	PUNCT
gs-3446	443	19	●	●	NUM
gs-3446	443	20	stem	stem	NOUN
gs-3446	443	21	cell	cell	NOUN
gs-3446	443	22	transplantation	transplantation	NOUN
gs-3446	443	23	:	:	PUNCT
gs-3446	443	24	bone	bone	NOUN
gs-3446	443	25	marrow	marrow	NOUN
gs-3446	443	26	transplants	transplant	NOUN
gs-3446	443	27	restore	restore	VERB
gs-3446	443	28	hematopoietic	hematopoietic	ADJ
gs-3446	443	29	function	function	NOUN
gs-3446	443	30	in	in	ADP
gs-3446	443	31	leukemia	leukemia	NOUN
gs-3446	443	32	patients	patient	NOUN
gs-3446	443	33	.	.	PUNCT
gs-3446	444	1	●	●	PUNCT
gs-3446	444	2	regenerative	regenerative	ADJ
gs-3446	444	3	medicine	medicine	NOUN
gs-3446	444	4	:	:	PUNCT
gs-3446	444	5	induced	induce	VERB
gs-3446	444	6	pluripotent	pluripotent	ADJ
gs-3446	444	7	stem	stem	NOUN
gs-3446	444	8	cells	cell	NOUN
gs-3446	444	9	(	(	PUNCT
gs-3446	444	10	ipscs	ipscs	NOUN
gs-3446	444	11	)	)	PUNCT
gs-3446	444	12	offer	offer	VERB
gs-3446	444	13	potential	potential	NOUN
gs-3446	444	14	for	for	ADP
gs-3446	444	15	disease	disease	NOUN
gs-3446	444	16	modeling	modeling	NOUN
gs-3446	444	17	,	,	PUNCT
gs-3446	444	18	drug	drug	NOUN
gs-3446	444	19	screening	screening	NOUN
gs-3446	444	20	,	,	PUNCT
gs-3446	444	21	and	and	CCONJ
gs-3446	444	22	tissue	tissue	NOUN
gs-3446	444	23	engineering	engineering	NOUN
gs-3446	444	24	.	.	PUNCT
gs-3446	445	1	●	●	PUNCT
gs-3446	445	2	gene	gene	NOUN
gs-3446	445	3	editing	editing	NOUN
gs-3446	445	4	(	(	PUNCT
gs-3446	445	5	crispr	crispr	NOUN
gs-3446	445	6	/	/	SYM
gs-3446	445	7	cas9	cas9	NOUN
gs-3446	445	8	):	):	PUNCT
gs-3446	445	9	enables	enable	VERB
gs-3446	445	10	targeted	targeted	ADJ
gs-3446	445	11	correction	correction	NOUN
gs-3446	445	12	of	of	ADP
gs-3446	445	13	mutations	mutation	NOUN
gs-3446	445	14	affecting	affect	VERB
gs-3446	445	15	stem	stem	NOUN
gs-3446	445	16	cell	cell	NOUN
gs-3446	445	17	function	function	NOUN
gs-3446	445	18	.	.	PUNCT
gs-3446	446	1	●	●	PUNCT
gs-3446	446	2	pharmacological	pharmacological	ADJ
gs-3446	446	3	approaches	approach	NOUN
gs-3446	446	4	:	:	PUNCT
gs-3446	446	5	small	small	ADJ
gs-3446	446	6	molecules	molecule	NOUN
gs-3446	446	7	and	and	CCONJ
gs-3446	446	8	biologics	biologic	NOUN
gs-3446	446	9	that	that	PRON
gs-3446	446	10	modulate	modulate	VERB
gs-3446	446	11	wnt	wnt	NOUN
gs-3446	446	12	,	,	PUNCT
gs-3446	446	13	notch	notch	NOUN
gs-3446	446	14	,	,	PUNCT
gs-3446	446	15	or	or	CCONJ
gs-3446	446	16	bmp	bmp	PROPN
gs-3446	446	17	pathways	pathway	NOUN
gs-3446	446	18	are	be	AUX
gs-3446	446	19	being	be	AUX
gs-3446	446	20	explored	explore	VERB
gs-3446	446	21	to	to	PART
gs-3446	446	22	restore	restore	VERB
gs-3446	446	23	homeostasis	homeostasis	NOUN
gs-3446	446	24	in	in	ADP
gs-3446	446	25	degenerative	degenerative	ADJ
gs-3446	446	26	diseases	disease	NOUN
gs-3446	446	27	.	.	PUNCT
gs-3446	447	1	stem	stem	NOUN
gs-3446	447	2	cell	cell	NOUN
gs-3446	447	3	homeostasis	homeostasis	NOUN
gs-3446	447	4	is	be	AUX
gs-3446	447	5	a	a	DET
gs-3446	447	6	fundamental	fundamental	ADJ
gs-3446	447	7	biological	biological	ADJ
gs-3446	447	8	process	process	NOUN
gs-3446	447	9	that	that	PRON
gs-3446	447	10	ensures	ensure	VERB
gs-3446	447	11	proper	proper	ADJ
gs-3446	447	12	tissue	tissue	NOUN
gs-3446	447	13	maintenance	maintenance	NOUN
gs-3446	447	14	and	and	CCONJ
gs-3446	447	15	repair	repair	NOUN
gs-3446	447	16	throughout	throughout	ADP
gs-3446	447	17	life	life	NOUN
gs-3446	447	18	.	.	PUNCT
gs-3446	448	1	it	it	PRON
gs-3446	448	2	is	be	AUX
gs-3446	448	3	governed	govern	VERB
gs-3446	448	4	by	by	ADP
gs-3446	448	5	intrinsic	intrinsic	ADJ
gs-3446	448	6	genetic	genetic	ADJ
gs-3446	448	7	programs	program	NOUN
gs-3446	448	8	and	and	CCONJ
gs-3446	448	9	extrinsic	extrinsic	ADJ
gs-3446	448	10	niche	niche	NOUN
gs-3446	448	11	signals	signal	NOUN
gs-3446	448	12	that	that	PRON
gs-3446	448	13	maintain	maintain	VERB
gs-3446	448	14	a	a	DET
gs-3446	448	15	delicate	delicate	ADJ
gs-3446	448	16	balance	balance	NOUN
gs-3446	448	17	between	between	ADP
gs-3446	448	18	self	self	NOUN
gs-3446	448	19	-	-	PUNCT
gs-3446	448	20	renewal	renewal	NOUN
gs-3446	448	21	and	and	CCONJ
gs-3446	448	22	differentiation	differentiation	NOUN
gs-3446	448	23	.	.	PUNCT
gs-3446	449	1	disruptions	disruption	NOUN
gs-3446	449	2	in	in	ADP
gs-3446	449	3	these	these	DET
gs-3446	449	4	mechanisms	mechanism	NOUN
gs-3446	449	5	contribute	contribute	VERB
gs-3446	449	6	to	to	ADP
gs-3446	449	7	aging	age	VERB
gs-3446	449	8	,	,	PUNCT
gs-3446	449	9	degenerative	degenerative	ADJ
gs-3446	449	10	diseases	disease	NOUN
gs-3446	449	11	,	,	PUNCT
gs-3446	449	12	and	and	CCONJ
gs-3446	449	13	cancer	cancer	NOUN
gs-3446	449	14	.	.	PUNCT
gs-3446	450	1	understanding	understanding	NOUN
gs-3446	450	2	and	and	CCONJ
gs-3446	450	3	manipulating	manipulate	VERB
gs-3446	450	4	stem	stem	NOUN
gs-3446	450	5	cell	cell	NOUN
gs-3446	450	6	homeostasis	homeostasis	NOUN
gs-3446	450	7	holds	hold	VERB
gs-3446	450	8	significant	significant	ADJ
gs-3446	450	9	promise	promise	NOUN
gs-3446	450	10	for	for	ADP
gs-3446	450	11	advancing	advance	VERB
gs-3446	450	12	regenerative	regenerative	ADJ
gs-3446	450	13	medicine	medicine	NOUN
gs-3446	450	14	,	,	PUNCT
gs-3446	450	15	improving	improve	VERB
gs-3446	450	16	therapies	therapy	NOUN
gs-3446	450	17	for	for	ADP
gs-3446	450	18	age	age	NOUN
gs-3446	450	19	-	-	PUNCT
gs-3446	450	20	related	relate	VERB
gs-3446	450	21	diseases	disease	NOUN
gs-3446	450	22	,	,	PUNCT
gs-3446	450	23	and	and	CCONJ
gs-3446	450	24	developing	develop	VERB
gs-3446	450	25	targeted	target	VERB
gs-3446	450	26	treatments	treatment	NOUN
gs-3446	450	27	for	for	ADP
gs-3446	450	28	cancer	cancer	NOUN
gs-3446	450	29	(	(	PUNCT
gs-3446	450	30	sulashvili	sulashvili	NOUN
gs-3446	450	31	et	et	PROPN
gs-3446	450	32	al	al	PROPN
gs-3446	450	33	.	.	PROPN
gs-3446	450	34	,	,	PUNCT
gs-3446	450	35	2024	2024	NUM
gs-3446	450	36	)	)	PUNCT
gs-3446	450	37	.	.	PUNCT
gs-3446	451	1	stem	stem	NOUN
gs-3446	451	2	cell	cell	NOUN
gs-3446	451	3	homeostasis	homeostasis	NOUN
gs-3446	451	4	is	be	AUX
gs-3446	451	5	a	a	DET
gs-3446	451	6	crucial	crucial	ADJ
gs-3446	451	7	aspect	aspect	NOUN
gs-3446	451	8	of	of	ADP
gs-3446	451	9	tissue	tissue	NOUN
gs-3446	451	10	maintenance	maintenance	NOUN
gs-3446	451	11	and	and	CCONJ
gs-3446	451	12	regeneration	regeneration	NOUN
gs-3446	451	13	,	,	PUNCT
gs-3446	451	14	ensuring	ensure	VERB
gs-3446	451	15	a	a	DET
gs-3446	451	16	balance	balance	NOUN
gs-3446	451	17	between	between	ADP
gs-3446	451	18	self	self	NOUN
gs-3446	451	19	-	-	PUNCT
gs-3446	451	20	renewal	renewal	NOUN
gs-3446	451	21	and	and	CCONJ
gs-3446	451	22	differentiation	differentiation	NOUN
gs-3446	451	23	.	.	PUNCT
gs-3446	452	1	disruptions	disruption	NOUN
gs-3446	452	2	in	in	ADP
gs-3446	452	3	this	this	DET
gs-3446	452	4	balance	balance	NOUN
gs-3446	452	5	can	can	AUX
gs-3446	452	6	lead	lead	VERB
gs-3446	452	7	to	to	ADP
gs-3446	452	8	severe	severe	ADJ
gs-3446	452	9	consequences	consequence	NOUN
gs-3446	452	10	,	,	PUNCT
gs-3446	452	11	including	include	VERB
gs-3446	452	12	aging	age	VERB
gs-3446	452	13	-	-	PUNCT
gs-3446	452	14	related	relate	VERB
gs-3446	452	15	degeneration	degeneration	NOUN
gs-3446	452	16	and	and	CCONJ
gs-3446	452	17	cancer	cancer	NOUN
gs-3446	452	18	.	.	PUNCT
gs-3446	453	1	the	the	DET
gs-3446	453	2	regulation	regulation	NOUN
gs-3446	453	3	of	of	ADP
gs-3446	453	4	stem	stem	NOUN
gs-3446	453	5	cell	cell	NOUN
gs-3446	453	6	homeostasis	homeostasis	NOUN
gs-3446	453	7	involves	involve	VERB
gs-3446	453	8	multiple	multiple	ADJ
gs-3446	453	9	levels	level	NOUN
gs-3446	453	10	of	of	ADP
gs-3446	453	11	control	control	NOUN
gs-3446	453	12	,	,	PUNCT
gs-3446	453	13	including	include	VERB
gs-3446	453	14	genetic	genetic	ADJ
gs-3446	453	15	,	,	PUNCT
gs-3446	453	16	epigenetic	epigenetic	ADJ
gs-3446	453	17	,	,	PUNCT
gs-3446	453	18	biochemical	biochemical	ADJ
gs-3446	453	19	,	,	PUNCT
gs-3446	453	20	and	and	CCONJ
gs-3446	453	21	environmental	environmental	ADJ
gs-3446	453	22	factors	factor	NOUN
gs-3446	453	23	.	.	PUNCT
gs-3446	454	1	in	in	ADP
gs-3446	454	2	this	this	DET
gs-3446	454	3	discussion	discussion	NOUN
gs-3446	454	4	,	,	PUNCT
gs-3446	454	5	we	we	PRON
gs-3446	454	6	explore	explore	VERB
gs-3446	454	7	the	the	DET
gs-3446	454	8	complexity	complexity	NOUN
gs-3446	454	9	of	of	ADP
gs-3446	454	10	these	these	DET
gs-3446	454	11	regulatory	regulatory	ADJ
gs-3446	454	12	mechanisms	mechanism	NOUN
gs-3446	454	13	,	,	PUNCT
gs-3446	454	14	the	the	DET
gs-3446	454	15	challenges	challenge	NOUN
gs-3446	454	16	in	in	ADP
gs-3446	454	17	maintaining	maintain	VERB
gs-3446	454	18	homeostasis	homeostasis	NOUN
gs-3446	454	19	,	,	PUNCT
gs-3446	454	20	and	and	CCONJ
gs-3446	454	21	potential	potential	ADJ
gs-3446	454	22	therapeutic	therapeutic	ADJ
gs-3446	454	23	applications	application	NOUN
gs-3446	454	24	(	(	PUNCT
gs-3446	454	25	sulashvili	sulashvili	NOUN
gs-3446	454	26	et	et	PROPN
gs-3446	454	27	al	al	PROPN
gs-3446	454	28	.	.	PROPN
gs-3446	454	29	,	,	PUNCT
gs-3446	454	30	2024	2024	NUM
gs-3446	454	31	)	)	PUNCT
gs-3446	454	32	.	.	PUNCT
gs-3446	455	1	georgian	georgian	ADJ
gs-3446	455	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	455	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	455	4	ტ.	ტ.	VERB
gs-3446	455	5	7	7	NUM
gs-3446	455	6	n	n	PRON
gs-3446	455	7	1	1	NUM
gs-3446	455	8	,	,	PUNCT
gs-3446	455	9	2025	2025	NUM
gs-3446	455	10	299	299	NUM
gs-3446	455	11	balancing	balance	VERB
gs-3446	455	12	self	self	NOUN
gs-3446	455	13	-	-	PUNCT
gs-3446	455	14	renewal	renewal	NOUN
gs-3446	455	15	and	and	CCONJ
gs-3446	455	16	differentiation	differentiation	NOUN
gs-3446	455	17	a	a	DET
gs-3446	455	18	central	central	ADJ
gs-3446	455	19	challenge	challenge	NOUN
gs-3446	455	20	in	in	ADP
gs-3446	455	21	stem	stem	NOUN
gs-3446	455	22	cell	cell	NOUN
gs-3446	455	23	biology	biology	NOUN
gs-3446	455	24	is	be	AUX
gs-3446	455	25	understanding	understand	VERB
gs-3446	455	26	how	how	SCONJ
gs-3446	455	27	stem	stem	NOUN
gs-3446	455	28	cells	cell	NOUN
gs-3446	455	29	maintain	maintain	VERB
gs-3446	455	30	their	their	PRON
gs-3446	455	31	capacity	capacity	NOUN
gs-3446	455	32	for	for	ADP
gs-3446	455	33	self	self	NOUN
gs-3446	455	34	-	-	PUNCT
gs-3446	455	35	renewal	renewal	NOUN
gs-3446	455	36	while	while	SCONJ
gs-3446	455	37	generating	generate	VERB
gs-3446	455	38	differentiated	differentiate	VERB
gs-3446	455	39	progeny	progeny	NOUN
gs-3446	455	40	in	in	ADP
gs-3446	455	41	response	response	NOUN
gs-3446	455	42	to	to	ADP
gs-3446	455	43	tissue	tissue	NOUN
gs-3446	455	44	needs	need	NOUN
gs-3446	455	45	.	.	PUNCT
gs-3446	456	1	this	this	DET
gs-3446	456	2	balance	balance	NOUN
gs-3446	456	3	is	be	AUX
gs-3446	456	4	influenced	influence	VERB
gs-3446	456	5	by	by	ADP
gs-3446	456	6	several	several	ADJ
gs-3446	456	7	key	key	ADJ
gs-3446	456	8	factors	factor	NOUN
gs-3446	456	9	:	:	PUNCT
gs-3446	456	10	●	●	NUM
gs-3446	456	11	stem	stem	NOUN
gs-3446	456	12	cell	cell	NOUN
gs-3446	456	13	niche	niche	NOUN
gs-3446	456	14	:	:	PUNCT
gs-3446	456	15	the	the	DET
gs-3446	456	16	microenvironment	microenvironment	NOUN
gs-3446	456	17	provides	provide	VERB
gs-3446	456	18	signals	signal	NOUN
gs-3446	456	19	that	that	PRON
gs-3446	456	20	maintain	maintain	VERB
gs-3446	456	21	stem	stem	NOUN
gs-3446	456	22	cell	cell	NOUN
gs-3446	456	23	identity	identity	NOUN
gs-3446	456	24	and	and	CCONJ
gs-3446	456	25	control	control	NOUN
gs-3446	456	26	differentiation	differentiation	NOUN
gs-3446	456	27	.	.	PUNCT
gs-3446	457	1	for	for	ADP
gs-3446	457	2	example	example	NOUN
gs-3446	457	3	,	,	PUNCT
gs-3446	457	4	hematopoietic	hematopoietic	ADJ
gs-3446	457	5	stem	stem	NOUN
gs-3446	457	6	cells	cell	NOUN
gs-3446	457	7	(	(	PUNCT
gs-3446	457	8	hscs	hsc	NOUN
gs-3446	457	9	)	)	PUNCT
gs-3446	457	10	rely	rely	VERB
gs-3446	457	11	on	on	ADP
gs-3446	457	12	cxcl12	cxcl12	ADJ
gs-3446	457	13	signaling	signal	VERB
gs-3446	457	14	from	from	ADP
gs-3446	457	15	niche	niche	NOUN
gs-3446	457	16	cells	cell	NOUN
gs-3446	457	17	for	for	ADP
gs-3446	457	18	quiescence	quiescence	NOUN
gs-3446	457	19	,	,	PUNCT
gs-3446	457	20	while	while	SCONJ
gs-3446	457	21	neural	neural	ADJ
gs-3446	457	22	stem	stem	NOUN
gs-3446	457	23	cells	cell	NOUN
gs-3446	457	24	(	(	PUNCT
gs-3446	457	25	nscs	nscs	PROPN
gs-3446	457	26	)	)	PUNCT
gs-3446	457	27	are	be	AUX
gs-3446	457	28	regulated	regulate	VERB
gs-3446	457	29	by	by	ADP
gs-3446	457	30	notch	notch	NOUN
gs-3446	457	31	and	and	CCONJ
gs-3446	457	32	bmp	bmp	NOUN
gs-3446	457	33	signaling	signal	VERB
gs-3446	457	34	in	in	ADP
gs-3446	457	35	the	the	DET
gs-3446	457	36	brain	brain	NOUN
gs-3446	457	37	.	.	PUNCT
gs-3446	458	1	●	●	PUNCT
gs-3446	458	2	intrinsic	intrinsic	ADJ
gs-3446	458	3	regulatory	regulatory	ADJ
gs-3446	458	4	networks	network	NOUN
gs-3446	458	5	:	:	PUNCT
gs-3446	458	6	transcription	transcription	NOUN
gs-3446	458	7	factors	factor	NOUN
gs-3446	458	8	such	such	ADJ
gs-3446	458	9	as	as	ADP
gs-3446	458	10	oct4	oct4	NOUN
gs-3446	458	11	,	,	PUNCT
gs-3446	458	12	sox2	sox2	NOUN
gs-3446	458	13	,	,	PUNCT
gs-3446	458	14	and	and	CCONJ
gs-3446	458	15	nanog	nanog	PROPN
gs-3446	458	16	maintain	maintain	VERB
gs-3446	458	17	pluripotency	pluripotency	NOUN
gs-3446	458	18	in	in	ADP
gs-3446	458	19	embryonic	embryonic	ADJ
gs-3446	458	20	stem	stem	NOUN
gs-3446	458	21	cells	cell	NOUN
gs-3446	458	22	(	(	PUNCT
gs-3446	458	23	escs	esc	NOUN
gs-3446	458	24	)	)	PUNCT
gs-3446	458	25	,	,	PUNCT
gs-3446	458	26	whereas	whereas	SCONJ
gs-3446	458	27	lineage	lineage	NOUN
gs-3446	458	28	-	-	PUNCT
gs-3446	458	29	specific	specific	ADJ
gs-3446	458	30	factors	factor	NOUN
gs-3446	458	31	like	like	ADP
gs-3446	458	32	myod	myod	NOUN
gs-3446	458	33	(	(	PUNCT
gs-3446	458	34	muscle	muscle	NOUN
gs-3446	458	35	differentiation	differentiation	NOUN
gs-3446	458	36	)	)	PUNCT
gs-3446	458	37	and	and	CCONJ
gs-3446	458	38	runx2	runx2	NOUN
gs-3446	458	39	(	(	PUNCT
gs-3446	458	40	bone	bone	NOUN
gs-3446	458	41	differentiation	differentiation	NOUN
gs-3446	458	42	)	)	PUNCT
gs-3446	458	43	drive	drive	VERB
gs-3446	458	44	specialized	specialized	ADJ
gs-3446	458	45	functions	function	NOUN
gs-3446	458	46	(	(	PUNCT
gs-3446	458	47	aphkhazava	aphkhazava	NOUN
gs-3446	458	48	et	et	PROPN
gs-3446	458	49	al	al	PROPN
gs-3446	458	50	.	.	PROPN
gs-3446	458	51	2023	2023	NUM
gs-3446	458	52	)	)	PUNCT
gs-3446	458	53	.	.	PUNCT
gs-3446	459	1	●	●	NUM
gs-3446	459	2	cell	cell	NOUN
gs-3446	459	3	cycle	cycle	NOUN
gs-3446	459	4	and	and	CCONJ
gs-3446	459	5	metabolic	metabolic	NOUN
gs-3446	459	6	control	control	NOUN
gs-3446	459	7	:	:	PUNCT
gs-3446	459	8	stem	stem	NOUN
gs-3446	459	9	cells	cell	NOUN
gs-3446	459	10	maintain	maintain	VERB
gs-3446	459	11	a	a	DET
gs-3446	459	12	delicate	delicate	ADJ
gs-3446	459	13	balance	balance	NOUN
gs-3446	459	14	between	between	ADP
gs-3446	459	15	quiescence	quiescence	NOUN
gs-3446	459	16	and	and	CCONJ
gs-3446	459	17	proliferation	proliferation	NOUN
gs-3446	459	18	.	.	PUNCT
gs-3446	460	1	while	while	SCONJ
gs-3446	460	2	quiescence	quiescence	NOUN
gs-3446	460	3	prevents	prevent	VERB
gs-3446	460	4	premature	premature	ADJ
gs-3446	460	5	exhaustion	exhaustion	NOUN
gs-3446	460	6	,	,	PUNCT
gs-3446	460	7	excessive	excessive	ADJ
gs-3446	460	8	proliferation	proliferation	NOUN
gs-3446	460	9	can	can	AUX
gs-3446	460	10	lead	lead	VERB
gs-3446	460	11	to	to	PART
gs-3446	460	12	stem	stem	VERB
gs-3446	460	13	cell	cell	NOUN
gs-3446	460	14	depletion	depletion	NOUN
gs-3446	460	15	or	or	CCONJ
gs-3446	460	16	tumorigenesis	tumorigenesis	NOUN
gs-3446	460	17	(	(	PUNCT
gs-3446	460	18	aphkhazava	aphkhazava	NOUN
gs-3446	460	19	et	et	PROPN
gs-3446	460	20	al	al	PROPN
gs-3446	460	21	.	.	PROPN
gs-3446	460	22	2024	2024	NUM
gs-3446	460	23	)	)	PUNCT
gs-3446	460	24	.	.	PUNCT
gs-3446	461	1	impact	impact	NOUN
gs-3446	461	2	of	of	ADP
gs-3446	461	3	aging	age	VERB
gs-3446	461	4	on	on	ADP
gs-3446	461	5	stem	stem	NOUN
gs-3446	461	6	cell	cell	NOUN
gs-3446	461	7	homeostasis	homeostasis	NOUN
gs-3446	461	8	aging	aging	NOUN
gs-3446	461	9	is	be	AUX
gs-3446	461	10	a	a	DET
gs-3446	461	11	significant	significant	ADJ
gs-3446	461	12	factor	factor	NOUN
gs-3446	461	13	affecting	affect	VERB
gs-3446	461	14	stem	stem	NOUN
gs-3446	461	15	cell	cell	NOUN
gs-3446	461	16	homeostasis	homeostasis	NOUN
gs-3446	461	17	,	,	PUNCT
gs-3446	461	18	leading	lead	VERB
gs-3446	461	19	to	to	ADP
gs-3446	461	20	reduced	reduce	VERB
gs-3446	461	21	regenerative	regenerative	ADJ
gs-3446	461	22	capacity	capacity	NOUN
gs-3446	461	23	and	and	CCONJ
gs-3446	461	24	increased	increase	VERB
gs-3446	461	25	susceptibility	susceptibility	NOUN
gs-3446	461	26	to	to	PART
gs-3446	461	27	disease	disease	VERB
gs-3446	461	28	.	.	PUNCT
gs-3446	462	1	key	key	ADJ
gs-3446	462	2	aging	age	VERB
gs-3446	462	3	-	-	PUNCT
gs-3446	462	4	related	relate	VERB
gs-3446	462	5	changes	change	NOUN
gs-3446	462	6	include	include	VERB
gs-3446	462	7	:	:	PUNCT
gs-3446	462	8	●	●	NUM
gs-3446	462	9	stem	stem	NOUN
gs-3446	462	10	cell	cell	NOUN
gs-3446	462	11	exhaustion	exhaustion	NOUN
gs-3446	462	12	:	:	PUNCT
gs-3446	462	13	over	over	ADP
gs-3446	462	14	time	time	NOUN
gs-3446	462	15	,	,	PUNCT
gs-3446	462	16	stem	stem	NOUN
gs-3446	462	17	cells	cell	NOUN
gs-3446	462	18	lose	lose	VERB
gs-3446	462	19	their	their	PRON
gs-3446	462	20	ability	ability	NOUN
gs-3446	462	21	to	to	PART
gs-3446	462	22	self	self	NOUN
gs-3446	462	23	-	-	PUNCT
gs-3446	462	24	renew	renew	NOUN
gs-3446	462	25	,	,	PUNCT
gs-3446	462	26	as	as	SCONJ
gs-3446	462	27	seen	see	VERB
gs-3446	462	28	in	in	ADP
gs-3446	462	29	hscs	hsc	NOUN
gs-3446	462	30	,	,	PUNCT
gs-3446	462	31	which	which	PRON
gs-3446	462	32	become	become	VERB
gs-3446	462	33	biased	biased	ADJ
gs-3446	462	34	toward	toward	ADP
gs-3446	462	35	myeloid	myeloid	ADJ
gs-3446	462	36	differentiation	differentiation	NOUN
gs-3446	462	37	,	,	PUNCT
gs-3446	462	38	contributing	contribute	VERB
gs-3446	462	39	to	to	ADP
gs-3446	462	40	immune	immune	ADJ
gs-3446	462	41	dysfunction	dysfunction	NOUN
gs-3446	462	42	.	.	PUNCT
gs-3446	463	1	●	●	PUNCT
gs-3446	463	2	epigenetic	epigenetic	ADJ
gs-3446	463	3	alterations	alteration	NOUN
gs-3446	463	4	:	:	PUNCT
gs-3446	463	5	dna	dna	PROPN
gs-3446	463	6	methylation	methylation	NOUN
gs-3446	463	7	changes	change	NOUN
gs-3446	463	8	,	,	PUNCT
gs-3446	463	9	histone	histone	NOUN
gs-3446	463	10	modifications	modification	NOUN
gs-3446	463	11	,	,	PUNCT
gs-3446	463	12	and	and	CCONJ
gs-3446	463	13	chromatin	chromatin	NOUN
gs-3446	463	14	remodeling	remodeling	NOUN
gs-3446	463	15	affect	affect	VERB
gs-3446	463	16	gene	gene	NOUN
gs-3446	463	17	expression	expression	NOUN
gs-3446	463	18	in	in	ADP
gs-3446	463	19	aging	age	VERB
gs-3446	463	20	stem	stem	NOUN
gs-3446	463	21	cells	cell	NOUN
gs-3446	463	22	.	.	PUNCT
gs-3446	464	1	●	●	PUNCT
gs-3446	464	2	oxidative	oxidative	ADJ
gs-3446	464	3	stress	stress	NOUN
gs-3446	464	4	and	and	CCONJ
gs-3446	464	5	dna	dna	NOUN
gs-3446	464	6	damage	damage	NOUN
gs-3446	464	7	:	:	PUNCT
gs-3446	464	8	accumulation	accumulation	NOUN
gs-3446	464	9	of	of	ADP
gs-3446	464	10	reactive	reactive	ADJ
gs-3446	464	11	oxygen	oxygen	NOUN
gs-3446	464	12	species	specie	NOUN
gs-3446	464	13	(	(	PUNCT
gs-3446	464	14	ros	ros	PROPN
gs-3446	464	15	)	)	PUNCT
gs-3446	464	16	and	and	CCONJ
gs-3446	464	17	impaired	impaired	ADJ
gs-3446	464	18	dna	dna	PROPN
gs-3446	464	19	repair	repair	NOUN
gs-3446	464	20	mechanisms	mechanism	NOUN
gs-3446	464	21	contribute	contribute	VERB
gs-3446	464	22	to	to	AUX
gs-3446	464	23	stem	stem	NOUN
gs-3446	464	24	cell	cell	NOUN
gs-3446	464	25	aging	age	VERB
gs-3446	464	26	and	and	CCONJ
gs-3446	464	27	functional	functional	ADJ
gs-3446	464	28	decline	decline	NOUN
gs-3446	464	29	.	.	PUNCT
gs-3446	465	1	●	●	PUNCT
gs-3446	465	2	inflammation	inflammation	NOUN
gs-3446	465	3	:	:	PUNCT
gs-3446	465	4	chronic	chronic	ADJ
gs-3446	465	5	inflammation	inflammation	NOUN
gs-3446	465	6	,	,	PUNCT
gs-3446	465	7	driven	drive	VERB
gs-3446	465	8	by	by	ADP
gs-3446	465	9	cytokines	cytokine	NOUN
gs-3446	465	10	like	like	ADP
gs-3446	465	11	il-6	il-6	PRON
gs-3446	465	12	and	and	CCONJ
gs-3446	465	13	tnf	tnf	PROPN
gs-3446	465	14	-	-	PUNCT
gs-3446	465	15	α	α	PROPN
gs-3446	465	16	,	,	PUNCT
gs-3446	465	17	disrupts	disrupt	VERB
gs-3446	465	18	stem	stem	NOUN
gs-3446	465	19	cell	cell	NOUN
gs-3446	465	20	function	function	NOUN
gs-3446	465	21	and	and	CCONJ
gs-3446	465	22	promotes	promote	VERB
gs-3446	465	23	tissue	tissue	NOUN
gs-3446	465	24	degeneration	degeneration	NOUN
gs-3446	465	25	.	.	PUNCT
gs-3446	466	1	strategies	strategy	NOUN
gs-3446	466	2	to	to	PART
gs-3446	466	3	counteract	counteract	VERB
gs-3446	466	4	aging	aging	NOUN
gs-3446	466	5	-	-	PUNCT
gs-3446	466	6	related	relate	VERB
gs-3446	466	7	decline	decline	NOUN
gs-3446	466	8	in	in	ADP
gs-3446	466	9	stem	stem	NOUN
gs-3446	466	10	cell	cell	NOUN
gs-3446	466	11	function	function	NOUN
gs-3446	466	12	are	be	AUX
gs-3446	466	13	being	be	AUX
gs-3446	466	14	explored	explore	VERB
gs-3446	466	15	,	,	PUNCT
gs-3446	466	16	including	include	VERB
gs-3446	466	17	metabolic	metabolic	NOUN
gs-3446	466	18	interventions	intervention	NOUN
gs-3446	466	19	,	,	PUNCT
gs-3446	466	20	pharmacological	pharmacological	ADJ
gs-3446	466	21	activation	activation	NOUN
gs-3446	466	22	of	of	ADP
gs-3446	466	23	key	key	ADJ
gs-3446	466	24	pathways	pathway	NOUN
gs-3446	466	25	(	(	PUNCT
gs-3446	466	26	e.g.	e.g.	ADV
gs-3446	466	27	,	,	PUNCT
gs-3446	466	28	wnt	wnt	PROPN
gs-3446	466	29	and	and	CCONJ
gs-3446	466	30	nad+	nad+	PROPN
gs-3446	466	31	precursors	precursor	NOUN
gs-3446	466	32	)	)	PUNCT
gs-3446	466	33	,	,	PUNCT
gs-3446	466	34	and	and	CCONJ
gs-3446	466	35	stem	stem	NOUN
gs-3446	466	36	cell	cell	NOUN
gs-3446	466	37	rejuvenation	rejuvenation	NOUN
gs-3446	466	38	therapies	therapy	NOUN
gs-3446	466	39	(	(	PUNCT
gs-3446	466	40	gоргаслидзе	gоргаслидзе	NOUN
gs-3446	466	41	,	,	PUNCT
gs-3446	466	42	2023	2023	NUM
gs-3446	466	43	)	)	PUNCT
gs-3446	466	44	.	.	PUNCT
gs-3446	467	1	stem	stem	NOUN
gs-3446	467	2	cell	cell	NOUN
gs-3446	467	3	dysregulation	dysregulation	NOUN
gs-3446	467	4	in	in	ADP
gs-3446	467	5	cancer	cancer	NOUN
gs-3446	467	6	while	while	SCONJ
gs-3446	467	7	maintaining	maintain	VERB
gs-3446	467	8	stem	stem	NOUN
gs-3446	467	9	cell	cell	NOUN
gs-3446	467	10	homeostasis	homeostasis	NOUN
gs-3446	467	11	is	be	AUX
gs-3446	467	12	crucial	crucial	ADJ
gs-3446	467	13	for	for	ADP
gs-3446	467	14	tissue	tissue	NOUN
gs-3446	467	15	health	health	NOUN
gs-3446	467	16	,	,	PUNCT
gs-3446	467	17	dysregulation	dysregulation	NOUN
gs-3446	467	18	of	of	ADP
gs-3446	467	19	self	self	NOUN
gs-3446	467	20	-	-	PUNCT
gs-3446	467	21	renewal	renewal	NOUN
gs-3446	467	22	mechanisms	mechanism	NOUN
gs-3446	467	23	can	can	AUX
gs-3446	467	24	lead	lead	VERB
gs-3446	467	25	to	to	ADP
gs-3446	467	26	cancer	cancer	NOUN
gs-3446	467	27	.	.	PUNCT
gs-3446	468	1	cancer	cancer	NOUN
gs-3446	468	2	stem	stem	NOUN
gs-3446	468	3	cells	cell	NOUN
gs-3446	468	4	(	(	PUNCT
gs-3446	468	5	cscs	cscs	PROPN
gs-3446	468	6	)	)	PUNCT
gs-3446	468	7	,	,	PUNCT
gs-3446	468	8	a	a	DET
gs-3446	468	9	subset	subset	NOUN
gs-3446	468	10	of	of	ADP
gs-3446	468	11	tumor	tumor	NOUN
gs-3446	468	12	cells	cell	NOUN
gs-3446	468	13	with	with	ADP
gs-3446	468	14	stem	stem	NOUN
gs-3446	468	15	-	-	PUNCT
gs-3446	468	16	like	like	ADJ
gs-3446	468	17	properties	property	NOUN
gs-3446	468	18	,	,	PUNCT
gs-3446	468	19	contribute	contribute	VERB
gs-3446	468	20	to	to	ADP
gs-3446	468	21	tumor	tumor	NOUN
gs-3446	468	22	initiation	initiation	NOUN
gs-3446	468	23	,	,	PUNCT
gs-3446	468	24	progression	progression	NOUN
gs-3446	468	25	,	,	PUNCT
gs-3446	468	26	and	and	CCONJ
gs-3446	468	27	resistance	resistance	NOUN
gs-3446	468	28	to	to	ADP
gs-3446	468	29	therapy	therapy	NOUN
gs-3446	468	30	(	(	PUNCT
gs-3446	468	31	aphkhazava	aphkhazava	NOUN
gs-3446	468	32	et	et	PROPN
gs-3446	468	33	al	al	PROPN
gs-3446	468	34	.	.	PROPN
gs-3446	468	35	2024	2024	NUM
gs-3446	468	36	)	)	PUNCT
gs-3446	468	37	.	.	PUNCT
gs-3446	469	1	georgian	georgian	ADJ
gs-3446	469	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	469	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	469	4	ტ.	ტ.	VERB
gs-3446	469	5	7	7	NUM
gs-3446	469	6	n	n	PRON
gs-3446	469	7	1	1	NUM
gs-3446	469	8	,	,	PUNCT
gs-3446	469	9	2025	2025	NUM
gs-3446	469	10	300	300	NUM
gs-3446	469	11	major	major	ADJ
gs-3446	469	12	factors	factor	NOUN
gs-3446	469	13	in	in	ADP
gs-3446	469	14	csc	csc	PROPN
gs-3446	469	15	regulation	regulation	NOUN
gs-3446	469	16	include	include	VERB
gs-3446	469	17	:	:	PUNCT
gs-3446	469	18	●	●	PUNCT
gs-3446	469	19	oncogenic	oncogenic	ADJ
gs-3446	469	20	signaling	signal	VERB
gs-3446	469	21	pathways	pathway	NOUN
gs-3446	469	22	:	:	PUNCT
gs-3446	469	23	aberrant	aberrant	ADJ
gs-3446	469	24	activation	activation	NOUN
gs-3446	469	25	of	of	ADP
gs-3446	469	26	wnt	wnt	PROPN
gs-3446	469	27	,	,	PUNCT
gs-3446	469	28	hedgehog	hedgehog	NOUN
gs-3446	469	29	,	,	PUNCT
gs-3446	469	30	and	and	CCONJ
gs-3446	469	31	notch	notch	VERB
gs-3446	469	32	signaling	signal	VERB
gs-3446	469	33	drives	drive	NOUN
gs-3446	469	34	uncontrolled	uncontrolled	ADJ
gs-3446	469	35	proliferation	proliferation	NOUN
gs-3446	469	36	in	in	ADP
gs-3446	469	37	cscs	cscs	PROPN
gs-3446	469	38	.	.	PUNCT
gs-3446	470	1	●	●	PUNCT
gs-3446	470	2	epigenetic	epigenetic	ADJ
gs-3446	470	3	modifications	modification	NOUN
gs-3446	470	4	:	:	PUNCT
gs-3446	470	5	changes	change	NOUN
gs-3446	470	6	in	in	ADP
gs-3446	470	7	dna	dna	PROPN
gs-3446	470	8	methylation	methylation	NOUN
gs-3446	470	9	and	and	CCONJ
gs-3446	470	10	histone	histone	NOUN
gs-3446	470	11	acetylation	acetylation	NOUN
gs-3446	470	12	alter	alter	NOUN
gs-3446	470	13	gene	gene	NOUN
gs-3446	470	14	expression	expression	NOUN
gs-3446	470	15	patterns	pattern	NOUN
gs-3446	470	16	,	,	PUNCT
gs-3446	470	17	leading	lead	VERB
gs-3446	470	18	to	to	ADP
gs-3446	470	19	loss	loss	NOUN
gs-3446	470	20	of	of	ADP
gs-3446	470	21	normal	normal	ADJ
gs-3446	470	22	stem	stem	NOUN
gs-3446	470	23	cell	cell	NOUN
gs-3446	470	24	regulation	regulation	NOUN
gs-3446	470	25	.	.	PUNCT
gs-3446	471	1	●	●	PUNCT
gs-3446	471	2	therapy	therapy	NOUN
gs-3446	471	3	resistance	resistance	NOUN
gs-3446	471	4	:	:	PUNCT
gs-3446	471	5	cscs	cscs	PROPN
gs-3446	471	6	exhibit	exhibit	VERB
gs-3446	471	7	resistance	resistance	NOUN
gs-3446	471	8	to	to	ADP
gs-3446	471	9	chemotherapy	chemotherapy	NOUN
gs-3446	471	10	and	and	CCONJ
gs-3446	471	11	radiation	radiation	NOUN
gs-3446	471	12	due	due	ADP
gs-3446	471	13	to	to	ADP
gs-3446	471	14	their	their	PRON
gs-3446	471	15	quiescent	quiescent	ADJ
gs-3446	471	16	nature	nature	NOUN
gs-3446	471	17	,	,	PUNCT
gs-3446	471	18	efficient	efficient	ADJ
gs-3446	471	19	dna	dna	PROPN
gs-3446	471	20	repair	repair	NOUN
gs-3446	471	21	,	,	PUNCT
gs-3446	471	22	and	and	CCONJ
gs-3446	471	23	expression	expression	NOUN
gs-3446	471	24	of	of	ADP
gs-3446	471	25	drug	drug	NOUN
gs-3446	471	26	efflux	efflux	NOUN
gs-3446	471	27	transporters	transporter	NOUN
gs-3446	471	28	.	.	PUNCT
gs-3446	472	1	targeting	target	VERB
gs-3446	472	2	cscs	cscs	PROPN
gs-3446	472	3	is	be	AUX
gs-3446	472	4	a	a	DET
gs-3446	472	5	major	major	ADJ
gs-3446	472	6	focus	focus	NOUN
gs-3446	472	7	in	in	ADP
gs-3446	472	8	cancer	cancer	NOUN
gs-3446	472	9	therapy	therapy	NOUN
gs-3446	472	10	,	,	PUNCT
gs-3446	472	11	with	with	ADP
gs-3446	472	12	approaches	approach	NOUN
gs-3446	472	13	such	such	ADJ
gs-3446	472	14	as	as	ADP
gs-3446	472	15	wnt	wnt	NOUN
gs-3446	472	16	/	/	SYM
gs-3446	472	17	notch	notch	NOUN
gs-3446	472	18	inhibitors	inhibitor	NOUN
gs-3446	472	19	,	,	PUNCT
gs-3446	472	20	immune	immune	NOUN
gs-3446	472	21	-	-	PUNCT
gs-3446	472	22	based	base	VERB
gs-3446	472	23	therapies	therapy	NOUN
gs-3446	472	24	,	,	PUNCT
gs-3446	472	25	and	and	CCONJ
gs-3446	472	26	metabolic	metabolic	NOUN
gs-3446	472	27	interventions	intervention	NOUN
gs-3446	472	28	being	be	AUX
gs-3446	472	29	investigated	investigate	VERB
gs-3446	472	30	to	to	PART
gs-3446	472	31	eliminate	eliminate	VERB
gs-3446	472	32	csc	csc	PROPN
gs-3446	472	33	populations	population	NOUN
gs-3446	472	34	while	while	SCONJ
gs-3446	472	35	preserving	preserve	VERB
gs-3446	472	36	normal	normal	ADJ
gs-3446	472	37	stem	stem	NOUN
gs-3446	472	38	cell	cell	NOUN
gs-3446	472	39	function	function	NOUN
gs-3446	472	40	.	.	PUNCT
gs-3446	473	1	therapeutic	therapeutic	ADJ
gs-3446	473	2	manipulation	manipulation	NOUN
gs-3446	473	3	of	of	ADP
gs-3446	473	4	stem	stem	NOUN
gs-3446	473	5	cell	cell	NOUN
gs-3446	473	6	homeostasis	homeostasis	NOUN
gs-3446	473	7	advancements	advancement	NOUN
gs-3446	473	8	in	in	ADP
gs-3446	473	9	stem	stem	NOUN
gs-3446	473	10	cell	cell	NOUN
gs-3446	473	11	research	research	NOUN
gs-3446	473	12	have	have	AUX
gs-3446	473	13	opened	open	VERB
gs-3446	473	14	avenues	avenue	NOUN
gs-3446	473	15	for	for	ADP
gs-3446	473	16	therapeutic	therapeutic	ADJ
gs-3446	473	17	manipulation	manipulation	NOUN
gs-3446	473	18	of	of	ADP
gs-3446	473	19	homeostasis	homeostasis	NOUN
gs-3446	473	20	in	in	ADP
gs-3446	473	21	various	various	ADJ
gs-3446	473	22	diseases	disease	NOUN
gs-3446	473	23	:	:	PUNCT
gs-3446	473	24	●	●	NUM
gs-3446	473	25	regenerative	regenerative	ADJ
gs-3446	473	26	medicine	medicine	NOUN
gs-3446	473	27	:	:	PUNCT
gs-3446	473	28	stem	stem	VERB
gs-3446	473	29	cell	cell	NOUN
gs-3446	473	30	-	-	PUNCT
gs-3446	473	31	based	base	VERB
gs-3446	473	32	therapies	therapy	NOUN
gs-3446	473	33	are	be	AUX
gs-3446	473	34	being	be	AUX
gs-3446	473	35	explored	explore	VERB
gs-3446	473	36	for	for	ADP
gs-3446	473	37	conditions	condition	NOUN
gs-3446	473	38	like	like	ADP
gs-3446	473	39	spinal	spinal	NOUN
gs-3446	473	40	cord	cord	NOUN
gs-3446	473	41	injury	injury	NOUN
gs-3446	473	42	,	,	PUNCT
gs-3446	473	43	parkinson	parkinson	NOUN
gs-3446	473	44	’s	’s	PART
gs-3446	473	45	disease	disease	NOUN
gs-3446	473	46	,	,	PUNCT
gs-3446	473	47	and	and	CCONJ
gs-3446	473	48	heart	heart	NOUN
gs-3446	473	49	failure	failure	NOUN
gs-3446	473	50	.	.	PUNCT
gs-3446	474	1	induced	induce	VERB
gs-3446	474	2	pluripotent	pluripotent	ADJ
gs-3446	474	3	stem	stem	NOUN
gs-3446	474	4	cells	cell	NOUN
gs-3446	474	5	(	(	PUNCT
gs-3446	474	6	ipscs	ipscs	NOUN
gs-3446	474	7	)	)	PUNCT
gs-3446	474	8	offer	offer	NOUN
gs-3446	474	9	personalized	personalize	VERB
gs-3446	474	10	regenerative	regenerative	ADJ
gs-3446	474	11	solutions	solution	NOUN
gs-3446	474	12	by	by	ADP
gs-3446	474	13	reprogramming	reprogramme	VERB
gs-3446	474	14	patient	patient	NOUN
gs-3446	474	15	-	-	PUNCT
gs-3446	474	16	derived	derive	VERB
gs-3446	474	17	cells	cell	NOUN
gs-3446	474	18	.	.	PUNCT
gs-3446	475	1	●	●	NUM
gs-3446	475	2	gene	gene	NOUN
gs-3446	475	3	editing	editing	NOUN
gs-3446	475	4	and	and	CCONJ
gs-3446	475	5	crispr	crispr	NOUN
gs-3446	475	6	-	-	PUNCT
gs-3446	475	7	based	base	VERB
gs-3446	475	8	interventions	intervention	NOUN
gs-3446	475	9	:	:	PUNCT
gs-3446	475	10	targeted	target	VERB
gs-3446	475	11	gene	gene	NOUN
gs-3446	475	12	modifications	modification	NOUN
gs-3446	475	13	in	in	ADP
gs-3446	475	14	stem	stem	NOUN
gs-3446	475	15	cells	cell	NOUN
gs-3446	475	16	hold	hold	VERB
gs-3446	475	17	promise	promise	NOUN
gs-3446	475	18	for	for	ADP
gs-3446	475	19	treating	treat	VERB
gs-3446	475	20	genetic	genetic	ADJ
gs-3446	475	21	disorders	disorder	NOUN
gs-3446	475	22	such	such	ADJ
gs-3446	475	23	as	as	ADP
gs-3446	475	24	sickle	sickle	NOUN
gs-3446	475	25	cell	cell	NOUN
gs-3446	475	26	anemia	anemia	NOUN
gs-3446	475	27	and	and	CCONJ
gs-3446	475	28	muscular	muscular	ADJ
gs-3446	475	29	dystrophy	dystrophy	NOUN
gs-3446	475	30	.	.	PUNCT
gs-3446	476	1	●	●	NUM
gs-3446	476	2	pharmacological	pharmacological	ADJ
gs-3446	476	3	modulation	modulation	NOUN
gs-3446	476	4	:	:	PUNCT
gs-3446	476	5	small	small	ADJ
gs-3446	476	6	molecules	molecule	NOUN
gs-3446	476	7	and	and	CCONJ
gs-3446	476	8	biologics	biologic	NOUN
gs-3446	476	9	targeting	target	VERB
gs-3446	476	10	wnt	wnt	NOUN
gs-3446	476	11	,	,	PUNCT
gs-3446	476	12	notch	notch	NOUN
gs-3446	476	13	,	,	PUNCT
gs-3446	476	14	or	or	CCONJ
gs-3446	476	15	bmp	bmp	NOUN
gs-3446	476	16	pathways	pathway	NOUN
gs-3446	476	17	can	can	AUX
gs-3446	476	18	restore	restore	VERB
gs-3446	476	19	proper	proper	ADJ
gs-3446	476	20	stem	stem	NOUN
gs-3446	476	21	cell	cell	NOUN
gs-3446	476	22	function	function	NOUN
gs-3446	476	23	in	in	ADP
gs-3446	476	24	degenerative	degenerative	ADJ
gs-3446	476	25	diseases	disease	NOUN
gs-3446	476	26	.	.	PUNCT
gs-3446	477	1	●	●	PUNCT
gs-3446	477	2	artificial	artificial	ADJ
gs-3446	477	3	stem	stem	NOUN
gs-3446	477	4	cell	cell	NOUN
gs-3446	477	5	niches	niche	NOUN
gs-3446	477	6	:	:	PUNCT
gs-3446	477	7	bioengineering	bioengineere	VERB
gs-3446	477	8	approaches	approach	NOUN
gs-3446	477	9	are	be	AUX
gs-3446	477	10	being	be	AUX
gs-3446	477	11	developed	develop	VERB
gs-3446	477	12	to	to	PART
gs-3446	477	13	create	create	VERB
gs-3446	477	14	synthetic	synthetic	ADJ
gs-3446	477	15	niches	niche	NOUN
gs-3446	477	16	that	that	PRON
gs-3446	477	17	support	support	VERB
gs-3446	477	18	stem	stem	NOUN
gs-3446	477	19	cell	cell	NOUN
gs-3446	477	20	growth	growth	NOUN
gs-3446	477	21	and	and	CCONJ
gs-3446	477	22	differentiation	differentiation	NOUN
gs-3446	477	23	for	for	ADP
gs-3446	477	24	transplantation	transplantation	NOUN
gs-3446	477	25	therapies	therapy	NOUN
gs-3446	477	26	.	.	PUNCT
gs-3446	478	1	future	future	ADJ
gs-3446	478	2	perspectives	perspective	NOUN
gs-3446	478	3	and	and	CCONJ
gs-3446	478	4	challenges	challenge	NOUN
gs-3446	478	5	despite	despite	SCONJ
gs-3446	478	6	significant	significant	ADJ
gs-3446	478	7	progress	progress	NOUN
gs-3446	478	8	in	in	ADP
gs-3446	478	9	understanding	understand	VERB
gs-3446	478	10	stem	stem	NOUN
gs-3446	478	11	cell	cell	NOUN
gs-3446	478	12	homeostasis	homeostasis	NOUN
gs-3446	478	13	,	,	PUNCT
gs-3446	478	14	several	several	ADJ
gs-3446	478	15	challenges	challenge	NOUN
gs-3446	478	16	remain	remain	VERB
gs-3446	478	17	:	:	PUNCT
gs-3446	478	18	●	●	NUM
gs-3446	478	19	ethical	ethical	ADJ
gs-3446	478	20	concerns	concern	NOUN
gs-3446	478	21	:	:	PUNCT
gs-3446	478	22	the	the	DET
gs-3446	478	23	use	use	NOUN
gs-3446	478	24	of	of	ADP
gs-3446	478	25	embryonic	embryonic	ADJ
gs-3446	478	26	stem	stem	NOUN
gs-3446	478	27	cells	cell	NOUN
gs-3446	478	28	(	(	PUNCT
gs-3446	478	29	escs	esc	NOUN
gs-3446	478	30	)	)	PUNCT
gs-3446	478	31	in	in	ADP
gs-3446	478	32	research	research	NOUN
gs-3446	478	33	and	and	CCONJ
gs-3446	478	34	therapy	therapy	NOUN
gs-3446	478	35	raises	raise	VERB
gs-3446	478	36	ethical	ethical	ADJ
gs-3446	478	37	and	and	CCONJ
gs-3446	478	38	regulatory	regulatory	ADJ
gs-3446	478	39	considerations	consideration	NOUN
gs-3446	478	40	.	.	PUNCT
gs-3446	479	1	ipsc	ipsc	PROPN
gs-3446	479	2	technology	technology	PROPN
gs-3446	479	3	offers	offer	VERB
gs-3446	479	4	a	a	DET
gs-3446	479	5	promising	promising	ADJ
gs-3446	479	6	alternative	alternative	NOUN
gs-3446	479	7	but	but	CCONJ
gs-3446	479	8	requires	require	VERB
gs-3446	479	9	further	further	ADJ
gs-3446	479	10	optimization	optimization	NOUN
gs-3446	479	11	.	.	PUNCT
gs-3446	480	1	●	●	PUNCT
gs-3446	480	2	tumorigenic	tumorigenic	ADJ
gs-3446	480	3	risks	risk	NOUN
gs-3446	480	4	:	:	PUNCT
gs-3446	480	5	the	the	DET
gs-3446	480	6	potential	potential	NOUN
gs-3446	480	7	for	for	ADP
gs-3446	480	8	uncontrolled	uncontrolled	ADJ
gs-3446	480	9	proliferation	proliferation	NOUN
gs-3446	480	10	in	in	ADP
gs-3446	480	11	transplanted	transplanted	ADJ
gs-3446	480	12	stem	stem	NOUN
gs-3446	480	13	cells	cell	NOUN
gs-3446	480	14	must	must	AUX
gs-3446	480	15	be	be	AUX
gs-3446	480	16	addressed	address	VERB
gs-3446	480	17	through	through	ADP
gs-3446	480	18	precise	precise	ADJ
gs-3446	480	19	control	control	NOUN
gs-3446	480	20	mechanisms	mechanism	NOUN
gs-3446	480	21	.	.	PUNCT
gs-3446	481	1	●	●	PUNCT
gs-3446	481	2	long	long	ADJ
gs-3446	481	3	-	-	PUNCT
gs-3446	481	4	term	term	NOUN
gs-3446	481	5	integration	integration	NOUN
gs-3446	481	6	:	:	PUNCT
gs-3446	481	7	ensuring	ensure	VERB
gs-3446	481	8	that	that	SCONJ
gs-3446	481	9	transplanted	transplanted	ADJ
gs-3446	481	10	stem	stem	NOUN
gs-3446	481	11	cells	cell	NOUN
gs-3446	481	12	properly	properly	ADV
gs-3446	481	13	integrate	integrate	VERB
gs-3446	481	14	into	into	ADP
gs-3446	481	15	host	host	NOUN
gs-3446	481	16	tissues	tissue	NOUN
gs-3446	481	17	without	without	ADP
gs-3446	481	18	immune	immune	ADJ
gs-3446	481	19	rejection	rejection	NOUN
gs-3446	481	20	is	be	AUX
gs-3446	481	21	a	a	DET
gs-3446	481	22	key	key	ADJ
gs-3446	481	23	challenge	challenge	NOUN
gs-3446	481	24	.	.	PUNCT
gs-3446	482	1	georgian	georgian	ADJ
gs-3446	482	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	482	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	482	4	ტ.	ტ.	VERB
gs-3446	482	5	7	7	NUM
gs-3446	482	6	n	n	DET
gs-3446	482	7	1	1	NUM
gs-3446	482	8	,	,	PUNCT
gs-3446	482	9	2025	2025	NUM
gs-3446	482	10	301	301	NUM
gs-3446	482	11	molecular	molecular	ADJ
gs-3446	482	12	and	and	CCONJ
gs-3446	482	13	cellular	cellular	ADJ
gs-3446	482	14	regulation	regulation	NOUN
gs-3446	482	15	of	of	ADP
gs-3446	482	16	stem	stem	NOUN
gs-3446	482	17	cell	cell	NOUN
gs-3446	482	18	homeostasis	homeostasis	NOUN
gs-3446	482	19	stem	stem	NOUN
gs-3446	482	20	cell	cell	NOUN
gs-3446	482	21	homeostasis	homeostasis	NOUN
gs-3446	482	22	is	be	AUX
gs-3446	482	23	a	a	DET
gs-3446	482	24	complex	complex	ADJ
gs-3446	482	25	and	and	CCONJ
gs-3446	482	26	dynamic	dynamic	ADJ
gs-3446	482	27	process	process	NOUN
gs-3446	482	28	that	that	PRON
gs-3446	482	29	ensures	ensure	VERB
gs-3446	482	30	the	the	DET
gs-3446	482	31	proper	proper	ADJ
gs-3446	482	32	balance	balance	NOUN
gs-3446	482	33	between	between	ADP
gs-3446	482	34	selfrenewal	selfrenewal	NOUN
gs-3446	482	35	and	and	CCONJ
gs-3446	482	36	differentiation	differentiation	NOUN
gs-3446	482	37	,	,	PUNCT
gs-3446	482	38	which	which	PRON
gs-3446	482	39	is	be	AUX
gs-3446	482	40	critical	critical	ADJ
gs-3446	482	41	for	for	ADP
gs-3446	482	42	tissue	tissue	NOUN
gs-3446	482	43	maintenance	maintenance	NOUN
gs-3446	482	44	and	and	CCONJ
gs-3446	482	45	repair	repair	NOUN
gs-3446	482	46	.	.	PUNCT
gs-3446	483	1	a	a	DET
gs-3446	483	2	detailed	detailed	ADJ
gs-3446	483	3	analysis	analysis	NOUN
gs-3446	483	4	of	of	ADP
gs-3446	483	5	this	this	DET
gs-3446	483	6	equilibrium	equilibrium	NOUN
gs-3446	483	7	reveals	reveal	VERB
gs-3446	483	8	the	the	DET
gs-3446	483	9	intricate	intricate	ADJ
gs-3446	483	10	regulatory	regulatory	ADJ
gs-3446	483	11	mechanisms	mechanism	NOUN
gs-3446	483	12	,	,	PUNCT
gs-3446	483	13	the	the	DET
gs-3446	483	14	impact	impact	NOUN
gs-3446	483	15	of	of	ADP
gs-3446	483	16	internal	internal	ADJ
gs-3446	483	17	and	and	CCONJ
gs-3446	483	18	external	external	ADJ
gs-3446	483	19	factors	factor	NOUN
gs-3446	483	20	,	,	PUNCT
gs-3446	483	21	and	and	CCONJ
gs-3446	483	22	the	the	DET
gs-3446	483	23	consequences	consequence	NOUN
gs-3446	483	24	of	of	ADP
gs-3446	483	25	disruptions	disruption	NOUN
gs-3446	483	26	in	in	ADP
gs-3446	483	27	homeostasis	homeostasis	NOUN
gs-3446	483	28	.	.	PUNCT
gs-3446	484	1	this	this	DET
gs-3446	484	2	section	section	NOUN
gs-3446	484	3	critically	critically	ADV
gs-3446	484	4	examines	examine	VERB
gs-3446	484	5	key	key	ADJ
gs-3446	484	6	aspects	aspect	NOUN
gs-3446	484	7	of	of	ADP
gs-3446	484	8	stem	stem	NOUN
gs-3446	484	9	cell	cell	NOUN
gs-3446	484	10	homeostasis	homeostasis	NOUN
gs-3446	484	11	,	,	PUNCT
gs-3446	484	12	including	include	VERB
gs-3446	484	13	its	its	PRON
gs-3446	484	14	molecular	molecular	ADJ
gs-3446	484	15	regulation	regulation	NOUN
gs-3446	484	16	,	,	PUNCT
gs-3446	484	17	challenges	challenge	NOUN
gs-3446	484	18	in	in	ADP
gs-3446	484	19	maintaining	maintain	VERB
gs-3446	484	20	stability	stability	NOUN
gs-3446	484	21	,	,	PUNCT
gs-3446	484	22	and	and	CCONJ
gs-3446	484	23	implications	implication	NOUN
gs-3446	484	24	for	for	ADP
gs-3446	484	25	disease	disease	NOUN
gs-3446	484	26	and	and	CCONJ
gs-3446	484	27	therapy	therapy	NOUN
gs-3446	484	28	.	.	PUNCT
gs-3446	485	1	the	the	DET
gs-3446	485	2	balance	balance	NOUN
gs-3446	485	3	of	of	ADP
gs-3446	485	4	stem	stem	NOUN
gs-3446	485	5	cell	cell	NOUN
gs-3446	485	6	activity	activity	NOUN
gs-3446	485	7	is	be	AUX
gs-3446	485	8	tightly	tightly	ADV
gs-3446	485	9	regulated	regulate	VERB
gs-3446	485	10	at	at	ADP
gs-3446	485	11	multiple	multiple	ADJ
gs-3446	485	12	levels	level	NOUN
gs-3446	485	13	,	,	PUNCT
gs-3446	485	14	ensuring	ensure	VERB
gs-3446	485	15	controlled	control	VERB
gs-3446	485	16	proliferation	proliferation	NOUN
gs-3446	485	17	while	while	SCONJ
gs-3446	485	18	preventing	prevent	VERB
gs-3446	485	19	exhaustion	exhaustion	NOUN
gs-3446	485	20	or	or	CCONJ
gs-3446	485	21	tumorigenesis	tumorigenesis	NOUN
gs-3446	485	22	(	(	PUNCT
gs-3446	485	23	aphkhazava	aphkhazava	NOUN
gs-3446	485	24	et	et	PROPN
gs-3446	485	25	al	al	PROPN
gs-3446	485	26	.	.	PROPN
gs-3446	485	27	2024	2024	NUM
gs-3446	485	28	)	)	PUNCT
gs-3446	485	29	.	.	PUNCT
gs-3446	486	1	self	self	NOUN
gs-3446	486	2	-	-	PUNCT
gs-3446	486	3	renewal	renewal	NOUN
gs-3446	486	4	vs.	vs.	ADP
gs-3446	486	5	differentiation	differentiation	NOUN
gs-3446	486	6	balance	balance	NOUN
gs-3446	486	7	●	●	NUM
gs-3446	486	8	stem	stem	NOUN
gs-3446	486	9	cells	cell	NOUN
gs-3446	486	10	must	must	AUX
gs-3446	486	11	decide	decide	VERB
gs-3446	486	12	whether	whether	SCONJ
gs-3446	486	13	to	to	PART
gs-3446	486	14	remain	remain	VERB
gs-3446	486	15	in	in	ADP
gs-3446	486	16	a	a	DET
gs-3446	486	17	self	self	NOUN
gs-3446	486	18	-	-	PUNCT
gs-3446	486	19	renewing	renew	VERB
gs-3446	486	20	state	state	NOUN
gs-3446	486	21	or	or	CCONJ
gs-3446	486	22	differentiate	differentiate	VERB
gs-3446	486	23	into	into	ADP
gs-3446	486	24	specialized	specialized	ADJ
gs-3446	486	25	cells	cell	NOUN
gs-3446	486	26	.	.	PUNCT
gs-3446	487	1	this	this	DET
gs-3446	487	2	process	process	NOUN
gs-3446	487	3	is	be	AUX
gs-3446	487	4	influenced	influence	VERB
gs-3446	487	5	by	by	ADP
gs-3446	487	6	transcription	transcription	NOUN
gs-3446	487	7	factors	factor	NOUN
gs-3446	487	8	,	,	PUNCT
gs-3446	487	9	epigenetic	epigenetic	ADJ
gs-3446	487	10	changes	change	NOUN
gs-3446	487	11	,	,	PUNCT
gs-3446	487	12	and	and	CCONJ
gs-3446	487	13	environmental	environmental	ADJ
gs-3446	487	14	signals	signal	NOUN
gs-3446	487	15	.	.	PUNCT
gs-3446	488	1	●	●	PUNCT
gs-3446	488	2	pluripotent	pluripotent	ADJ
gs-3446	488	3	stem	stem	NOUN
gs-3446	488	4	cells	cell	NOUN
gs-3446	488	5	(	(	PUNCT
gs-3446	488	6	e.g.	e.g.	ADV
gs-3446	488	7	,	,	PUNCT
gs-3446	488	8	embryonic	embryonic	ADJ
gs-3446	488	9	stem	stem	NOUN
gs-3446	488	10	cells	cell	NOUN
gs-3446	488	11	)	)	PUNCT
gs-3446	488	12	maintain	maintain	VERB
gs-3446	488	13	their	their	PRON
gs-3446	488	14	identity	identity	NOUN
gs-3446	488	15	through	through	ADP
gs-3446	488	16	transcription	transcription	NOUN
gs-3446	488	17	factors	factor	NOUN
gs-3446	488	18	such	such	ADJ
gs-3446	488	19	as	as	ADP
gs-3446	488	20	oct4	oct4	NOUN
gs-3446	488	21	,	,	PUNCT
gs-3446	488	22	sox2	sox2	NOUN
gs-3446	488	23	,	,	PUNCT
gs-3446	488	24	and	and	CCONJ
gs-3446	488	25	nanog	nanog	PROPN
gs-3446	488	26	,	,	PUNCT
gs-3446	488	27	while	while	SCONJ
gs-3446	488	28	adult	adult	NOUN
gs-3446	488	29	stem	stem	NOUN
gs-3446	488	30	cells	cell	NOUN
gs-3446	488	31	rely	rely	VERB
gs-3446	488	32	on	on	ADP
gs-3446	488	33	niche	niche	NOUN
gs-3446	488	34	-	-	PUNCT
gs-3446	488	35	specific	specific	ADJ
gs-3446	488	36	cues	cue	NOUN
gs-3446	488	37	to	to	PART
gs-3446	488	38	regulate	regulate	VERB
gs-3446	488	39	differentiation	differentiation	NOUN
gs-3446	488	40	.	.	PUNCT
gs-3446	489	1	●	●	PUNCT
gs-3446	489	2	the	the	DET
gs-3446	489	3	notch	notch	NOUN
gs-3446	489	4	and	and	CCONJ
gs-3446	489	5	wnt	wnt	NOUN
gs-3446	489	6	signaling	signal	VERB
gs-3446	489	7	pathways	pathway	NOUN
gs-3446	489	8	are	be	AUX
gs-3446	489	9	key	key	ADJ
gs-3446	489	10	regulators	regulator	NOUN
gs-3446	489	11	of	of	ADP
gs-3446	489	12	self	self	NOUN
gs-3446	489	13	-	-	PUNCT
gs-3446	489	14	renewal	renewal	NOUN
gs-3446	489	15	,	,	PUNCT
gs-3446	489	16	while	while	SCONJ
gs-3446	489	17	differentiation	differentiation	NOUN
gs-3446	489	18	is	be	AUX
gs-3446	489	19	often	often	ADV
gs-3446	489	20	guided	guide	VERB
gs-3446	489	21	by	by	ADP
gs-3446	489	22	pathways	pathway	NOUN
gs-3446	489	23	like	like	ADP
gs-3446	489	24	bmp	bmp	PROPN
gs-3446	489	25	and	and	CCONJ
gs-3446	489	26	retinoic	retinoic	PROPN
gs-3446	489	27	acid	acid	PROPN
gs-3446	489	28	signaling	signaling	NOUN
gs-3446	489	29	.	.	PUNCT
gs-3446	490	1	role	role	NOUN
gs-3446	490	2	of	of	ADP
gs-3446	490	3	the	the	DET
gs-3446	490	4	stem	stem	NOUN
gs-3446	490	5	cell	cell	NOUN
gs-3446	490	6	niche	niche	NOUN
gs-3446	490	7	●	●	NUM
gs-3446	490	8	stem	stem	NOUN
gs-3446	490	9	cells	cell	NOUN
gs-3446	490	10	reside	reside	VERB
gs-3446	490	11	in	in	ADP
gs-3446	490	12	specialized	specialized	ADJ
gs-3446	490	13	microenvironments	microenvironment	NOUN
gs-3446	490	14	called	call	VERB
gs-3446	490	15	niches	niche	NOUN
gs-3446	490	16	,	,	PUNCT
gs-3446	490	17	which	which	PRON
gs-3446	490	18	provide	provide	VERB
gs-3446	490	19	extrinsic	extrinsic	ADJ
gs-3446	490	20	signals	signal	NOUN
gs-3446	490	21	necessary	necessary	ADJ
gs-3446	490	22	for	for	ADP
gs-3446	490	23	their	their	PRON
gs-3446	490	24	regulation	regulation	NOUN
gs-3446	490	25	.	.	PUNCT
gs-3446	491	1	●	●	PUNCT
gs-3446	491	2	examples	example	NOUN
gs-3446	491	3	include	include	VERB
gs-3446	491	4	:	:	PUNCT
gs-3446	491	5	○	○	ADJ
gs-3446	491	6	hematopoietic	hematopoietic	ADJ
gs-3446	491	7	stem	stem	NOUN
gs-3446	491	8	cells	cell	NOUN
gs-3446	491	9	(	(	PUNCT
gs-3446	491	10	hscs	hsc	NOUN
gs-3446	491	11	)	)	PUNCT
gs-3446	491	12	in	in	ADP
gs-3446	491	13	the	the	DET
gs-3446	491	14	bone	bone	NOUN
gs-3446	491	15	marrow	marrow	NOUN
gs-3446	491	16	niche	niche	NOUN
gs-3446	491	17	,	,	PUNCT
gs-3446	491	18	regulated	regulate	VERB
gs-3446	491	19	by	by	ADP
gs-3446	491	20	cxcl12	cxcl12	ADJ
gs-3446	491	21	and	and	CCONJ
gs-3446	491	22	scf	scf	PROPN
gs-3446	491	23	signaling	signaling	ADJ
gs-3446	491	24	.	.	PUNCT
gs-3446	492	1	○	○	ADJ
gs-3446	492	2	neural	neural	ADJ
gs-3446	492	3	stem	stem	NOUN
gs-3446	492	4	cells	cell	NOUN
gs-3446	492	5	(	(	PUNCT
gs-3446	492	6	nscs	nscs	PROPN
gs-3446	492	7	)	)	PUNCT
gs-3446	492	8	in	in	ADP
gs-3446	492	9	the	the	DET
gs-3446	492	10	subventricular	subventricular	PROPN
gs-3446	492	11	zone	zone	NOUN
gs-3446	492	12	,	,	PUNCT
gs-3446	492	13	influenced	influence	VERB
gs-3446	492	14	by	by	ADP
gs-3446	492	15	notch	notch	NOUN
gs-3446	492	16	and	and	CCONJ
gs-3446	492	17	bmp	bmp	NOUN
gs-3446	492	18	signaling	signaling	NOUN
gs-3446	492	19	.	.	PUNCT
gs-3446	493	1	●	●	PUNCT
gs-3446	493	2	the	the	DET
gs-3446	493	3	niche	niche	NOUN
gs-3446	493	4	helps	helps	AUX
gs-3446	493	5	maintain	maintain	VERB
gs-3446	493	6	quiescence	quiescence	NOUN
gs-3446	493	7	,	,	PUNCT
gs-3446	493	8	preventing	prevent	VERB
gs-3446	493	9	excessive	excessive	ADJ
gs-3446	493	10	proliferation	proliferation	NOUN
gs-3446	493	11	that	that	PRON
gs-3446	493	12	could	could	AUX
gs-3446	493	13	lead	lead	VERB
gs-3446	493	14	to	to	ADP
gs-3446	493	15	cancer	cancer	NOUN
gs-3446	493	16	while	while	SCONJ
gs-3446	493	17	also	also	ADV
gs-3446	493	18	ensuring	ensure	VERB
gs-3446	493	19	the	the	DET
gs-3446	493	20	availability	availability	NOUN
gs-3446	493	21	of	of	ADP
gs-3446	493	22	stem	stem	NOUN
gs-3446	493	23	cells	cell	NOUN
gs-3446	493	24	for	for	ADP
gs-3446	493	25	tissue	tissue	NOUN
gs-3446	493	26	regeneration	regeneration	NOUN
gs-3446	493	27	.	.	PUNCT
gs-3446	494	1	metabolic	metabolic	NOUN
gs-3446	494	2	and	and	CCONJ
gs-3446	494	3	epigenetic	epigenetic	ADJ
gs-3446	494	4	regulation	regulation	NOUN
gs-3446	494	5	●	●	NUM
gs-3446	494	6	stem	stem	NOUN
gs-3446	494	7	cells	cell	NOUN
gs-3446	494	8	exhibit	exhibit	VERB
gs-3446	494	9	distinct	distinct	ADJ
gs-3446	494	10	metabolic	metabolic	NOUN
gs-3446	494	11	states	state	NOUN
gs-3446	494	12	:	:	PUNCT
gs-3446	494	13	pluripotent	pluripotent	ADJ
gs-3446	494	14	cells	cell	NOUN
gs-3446	494	15	primarily	primarily	ADV
gs-3446	494	16	rely	rely	VERB
gs-3446	494	17	on	on	ADP
gs-3446	494	18	glycolysis	glycolysis	NOUN
gs-3446	494	19	,	,	PUNCT
gs-3446	494	20	whereas	whereas	SCONJ
gs-3446	494	21	differentiated	differentiated	ADJ
gs-3446	494	22	cells	cell	NOUN
gs-3446	494	23	shift	shift	VERB
gs-3446	494	24	towards	towards	ADP
gs-3446	494	25	oxidative	oxidative	ADJ
gs-3446	494	26	phosphorylation	phosphorylation	NOUN
gs-3446	494	27	.	.	PUNCT
gs-3446	495	1	●	●	PUNCT
gs-3446	495	2	epigenetic	epigenetic	ADJ
gs-3446	495	3	mechanisms	mechanism	NOUN
gs-3446	495	4	,	,	PUNCT
gs-3446	495	5	including	include	VERB
gs-3446	495	6	dna	dna	PROPN
gs-3446	495	7	methylation	methylation	NOUN
gs-3446	495	8	,	,	PUNCT
gs-3446	495	9	histone	histone	NOUN
gs-3446	495	10	modifications	modification	NOUN
gs-3446	495	11	,	,	PUNCT
gs-3446	495	12	and	and	CCONJ
gs-3446	495	13	non	non	ADJ
gs-3446	495	14	-	-	ADJ
gs-3446	495	15	coding	coding	ADJ
gs-3446	495	16	rnas	rna	NOUN
gs-3446	495	17	,	,	PUNCT
gs-3446	495	18	modulate	modulate	VERB
gs-3446	495	19	gene	gene	NOUN
gs-3446	495	20	expression	expression	NOUN
gs-3446	495	21	to	to	PART
gs-3446	495	22	maintain	maintain	VERB
gs-3446	495	23	stem	stem	NOUN
gs-3446	495	24	cell	cell	NOUN
gs-3446	495	25	identity	identity	NOUN
gs-3446	495	26	or	or	CCONJ
gs-3446	495	27	drive	drive	VERB
gs-3446	495	28	differentiation	differentiation	NOUN
gs-3446	495	29	.	.	PUNCT
gs-3446	496	1	georgian	georgian	ADJ
gs-3446	496	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	496	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	496	4	ტ.	ტ.	VERB
gs-3446	496	5	7	7	NUM
gs-3446	496	6	n	n	PRON
gs-3446	496	7	1	1	NUM
gs-3446	496	8	,	,	PUNCT
gs-3446	496	9	2025	2025	NUM
gs-3446	496	10	302	302	NUM
gs-3446	496	11	●	●	NUM
gs-3446	496	12	disruptions	disruption	NOUN
gs-3446	496	13	in	in	ADP
gs-3446	496	14	epigenetic	epigenetic	ADJ
gs-3446	496	15	regulation	regulation	NOUN
gs-3446	496	16	can	can	AUX
gs-3446	496	17	lead	lead	VERB
gs-3446	496	18	to	to	ADP
gs-3446	496	19	loss	loss	NOUN
gs-3446	496	20	of	of	ADP
gs-3446	496	21	homeostasis	homeostasis	NOUN
gs-3446	496	22	,	,	PUNCT
gs-3446	496	23	contributing	contribute	VERB
gs-3446	496	24	to	to	ADP
gs-3446	496	25	premature	premature	ADJ
gs-3446	496	26	aging	aging	NOUN
gs-3446	496	27	or	or	CCONJ
gs-3446	496	28	malignancy	malignancy	NOUN
gs-3446	496	29	.	.	PUNCT
gs-3446	497	1	challenges	challenge	NOUN
gs-3446	497	2	in	in	ADP
gs-3446	497	3	maintaining	maintain	VERB
gs-3446	497	4	stem	stem	NOUN
gs-3446	497	5	cell	cell	NOUN
gs-3446	497	6	homeostasis	homeostasis	NOUN
gs-3446	497	7	maintaining	maintain	VERB
gs-3446	497	8	stem	stem	NOUN
gs-3446	497	9	cell	cell	NOUN
gs-3446	497	10	homeostasis	homeostasis	NOUN
gs-3446	497	11	presents	present	VERB
gs-3446	497	12	several	several	ADJ
gs-3446	497	13	biological	biological	ADJ
gs-3446	497	14	challenges	challenge	NOUN
gs-3446	497	15	that	that	PRON
gs-3446	497	16	affect	affect	VERB
gs-3446	497	17	tissue	tissue	NOUN
gs-3446	497	18	function	function	NOUN
gs-3446	497	19	and	and	CCONJ
gs-3446	497	20	regenerative	regenerative	ADJ
gs-3446	497	21	capacity	capacity	NOUN
gs-3446	497	22	over	over	ADP
gs-3446	497	23	time	time	NOUN
gs-3446	497	24	.	.	PUNCT
gs-3446	498	1	aging	age	VERB
gs-3446	498	2	and	and	CCONJ
gs-3446	498	3	stem	stem	NOUN
gs-3446	498	4	cell	cell	NOUN
gs-3446	498	5	exhaustion	exhaustion	NOUN
gs-3446	498	6	●	●	PUNCT
gs-3446	498	7	aging	age	VERB
gs-3446	498	8	results	result	NOUN
gs-3446	498	9	in	in	ADP
gs-3446	498	10	progressive	progressive	ADJ
gs-3446	498	11	decline	decline	NOUN
gs-3446	498	12	in	in	ADP
gs-3446	498	13	stem	stem	NOUN
gs-3446	498	14	cell	cell	NOUN
gs-3446	498	15	function	function	NOUN
gs-3446	498	16	,	,	PUNCT
gs-3446	498	17	leading	lead	VERB
gs-3446	498	18	to	to	ADP
gs-3446	498	19	reduced	reduce	VERB
gs-3446	498	20	regenerative	regenerative	ADJ
gs-3446	498	21	potential	potential	NOUN
gs-3446	498	22	and	and	CCONJ
gs-3446	498	23	increased	increase	VERB
gs-3446	498	24	susceptibility	susceptibility	NOUN
gs-3446	498	25	to	to	PART
gs-3446	498	26	disease	disease	VERB
gs-3446	498	27	.	.	PUNCT
gs-3446	499	1	●	●	PUNCT
gs-3446	499	2	key	key	ADJ
gs-3446	499	3	aging	age	VERB
gs-3446	499	4	-	-	PUNCT
gs-3446	499	5	related	relate	VERB
gs-3446	499	6	changes	change	NOUN
gs-3446	499	7	include	include	VERB
gs-3446	499	8	:	:	PUNCT
gs-3446	499	9	○	○	PROPN
gs-3446	499	10	telomere	telomere	PROPN
gs-3446	499	11	shortening	shortening	NOUN
gs-3446	499	12	,	,	PUNCT
gs-3446	499	13	leading	lead	VERB
gs-3446	499	14	to	to	ADP
gs-3446	499	15	decreased	decrease	VERB
gs-3446	499	16	proliferation	proliferation	NOUN
gs-3446	499	17	.	.	PUNCT
gs-3446	500	1	○	○	PROPN
gs-3446	500	2	increased	increase	VERB
gs-3446	500	3	dna	dna	PROPN
gs-3446	500	4	damage	damage	NOUN
gs-3446	500	5	and	and	CCONJ
gs-3446	500	6	accumulation	accumulation	NOUN
gs-3446	500	7	of	of	ADP
gs-3446	500	8	mutations	mutation	NOUN
gs-3446	500	9	.	.	PUNCT
gs-3446	501	1	○	○	ADJ
gs-3446	501	2	chronic	chronic	ADJ
gs-3446	501	3	inflammation	inflammation	NOUN
gs-3446	501	4	,	,	PUNCT
gs-3446	501	5	which	which	PRON
gs-3446	501	6	alters	alter	VERB
gs-3446	501	7	the	the	DET
gs-3446	501	8	niche	niche	NOUN
gs-3446	501	9	and	and	CCONJ
gs-3446	501	10	disrupts	disrupt	VERB
gs-3446	501	11	stem	stem	NOUN
gs-3446	501	12	cell	cell	NOUN
gs-3446	501	13	function	function	NOUN
gs-3446	501	14	.	.	PUNCT
gs-3446	502	1	●	●	PUNCT
gs-3446	502	2	example	example	NOUN
gs-3446	502	3	:	:	PUNCT
gs-3446	502	4	aged	aged	ADJ
gs-3446	502	5	hematopoietic	hematopoietic	ADJ
gs-3446	502	6	stem	stem	NOUN
gs-3446	502	7	cells	cell	NOUN
gs-3446	502	8	(	(	PUNCT
gs-3446	502	9	hscs	hsc	NOUN
gs-3446	502	10	)	)	PUNCT
gs-3446	502	11	exhibit	exhibit	VERB
gs-3446	502	12	myeloid	myeloid	ADJ
gs-3446	502	13	bias	bias	NOUN
gs-3446	502	14	,	,	PUNCT
gs-3446	502	15	reducing	reduce	VERB
gs-3446	502	16	the	the	DET
gs-3446	502	17	production	production	NOUN
gs-3446	502	18	of	of	ADP
gs-3446	502	19	lymphoid	lymphoid	ADJ
gs-3446	502	20	cells	cell	NOUN
gs-3446	502	21	and	and	CCONJ
gs-3446	502	22	weakening	weaken	VERB
gs-3446	502	23	immune	immune	ADJ
gs-3446	502	24	response	response	NOUN
gs-3446	502	25	.	.	PUNCT
gs-3446	503	1	oncogenic	oncogenic	ADJ
gs-3446	503	2	transformation	transformation	NOUN
gs-3446	503	3	and	and	CCONJ
gs-3446	503	4	cancer	cancer	NOUN
gs-3446	503	5	stem	stem	NOUN
gs-3446	503	6	cells	cell	NOUN
gs-3446	503	7	(	(	PUNCT
gs-3446	503	8	cscs	cscs	PROPN
gs-3446	503	9	)	)	PUNCT
gs-3446	503	10	●	●	NUM
gs-3446	503	11	dysregulation	dysregulation	NOUN
gs-3446	503	12	of	of	ADP
gs-3446	503	13	homeostasis	homeostasis	NOUN
gs-3446	503	14	can	can	AUX
gs-3446	503	15	lead	lead	VERB
gs-3446	503	16	to	to	ADP
gs-3446	503	17	the	the	DET
gs-3446	503	18	uncontrolled	uncontrolled	ADJ
gs-3446	503	19	proliferation	proliferation	NOUN
gs-3446	503	20	of	of	ADP
gs-3446	503	21	stem	stem	NOUN
gs-3446	503	22	cells	cell	NOUN
gs-3446	503	23	,	,	PUNCT
gs-3446	503	24	giving	give	VERB
gs-3446	503	25	rise	rise	NOUN
gs-3446	503	26	to	to	ADP
gs-3446	503	27	cancer	cancer	NOUN
gs-3446	503	28	stem	stem	NOUN
gs-3446	503	29	cells	cell	NOUN
gs-3446	503	30	(	(	PUNCT
gs-3446	503	31	cscs	cscs	PROPN
gs-3446	503	32	)	)	PUNCT
gs-3446	503	33	.	.	PUNCT
gs-3446	504	1	●	●	PUNCT
gs-3446	504	2	cscs	cscs	PROPN
gs-3446	504	3	retain	retain	VERB
gs-3446	504	4	self	self	NOUN
gs-3446	504	5	-	-	PUNCT
gs-3446	504	6	renewal	renewal	NOUN
gs-3446	504	7	capabilities	capability	NOUN
gs-3446	504	8	,	,	PUNCT
gs-3446	504	9	contributing	contribute	VERB
gs-3446	504	10	to	to	ADP
gs-3446	504	11	tumor	tumor	NOUN
gs-3446	504	12	initiation	initiation	NOUN
gs-3446	504	13	,	,	PUNCT
gs-3446	504	14	progression	progression	NOUN
gs-3446	504	15	,	,	PUNCT
gs-3446	504	16	and	and	CCONJ
gs-3446	504	17	therapy	therapy	NOUN
gs-3446	504	18	resistance	resistance	NOUN
gs-3446	504	19	.	.	PUNCT
gs-3446	505	1	●	●	PUNCT
gs-3446	505	2	oncogenic	oncogenic	ADJ
gs-3446	505	3	pathways	pathway	NOUN
gs-3446	505	4	such	such	ADJ
gs-3446	505	5	as	as	ADP
gs-3446	505	6	wnt	wnt	PROPN
gs-3446	505	7	,	,	PUNCT
gs-3446	505	8	hedgehog	hedgehog	NOUN
gs-3446	505	9	,	,	PUNCT
gs-3446	505	10	and	and	CCONJ
gs-3446	505	11	notch	notch	NOUN
gs-3446	505	12	are	be	AUX
gs-3446	505	13	frequently	frequently	ADV
gs-3446	505	14	overactivated	overactivate	VERB
gs-3446	505	15	in	in	ADP
gs-3446	505	16	cancers	cancer	NOUN
gs-3446	505	17	,	,	PUNCT
gs-3446	505	18	sustaining	sustain	VERB
gs-3446	505	19	csc	csc	PROPN
gs-3446	505	20	populations	population	NOUN
gs-3446	505	21	.	.	PUNCT
gs-3446	506	1	●	●	NOUN
gs-3446	506	2	example	example	NOUN
gs-3446	506	3	:	:	PUNCT
gs-3446	506	4	leukemic	leukemic	ADJ
gs-3446	506	5	stem	stem	NOUN
gs-3446	506	6	cells	cell	NOUN
gs-3446	506	7	(	(	PUNCT
gs-3446	506	8	lscs	lsc	NOUN
gs-3446	506	9	)	)	PUNCT
gs-3446	506	10	originate	originate	VERB
gs-3446	506	11	from	from	ADP
gs-3446	506	12	hematopoietic	hematopoietic	ADJ
gs-3446	506	13	stem	stem	NOUN
gs-3446	506	14	cells	cell	NOUN
gs-3446	506	15	with	with	ADP
gs-3446	506	16	mutations	mutation	NOUN
gs-3446	506	17	that	that	PRON
gs-3446	506	18	enhance	enhance	VERB
gs-3446	506	19	self	self	NOUN
gs-3446	506	20	-	-	PUNCT
gs-3446	506	21	renewal	renewal	NOUN
gs-3446	506	22	while	while	SCONJ
gs-3446	506	23	blocking	block	VERB
gs-3446	506	24	normal	normal	ADJ
gs-3446	506	25	differentiation	differentiation	NOUN
gs-3446	506	26	.	.	PUNCT
gs-3446	507	1	environmental	environmental	ADJ
gs-3446	507	2	and	and	CCONJ
gs-3446	507	3	systemic	systemic	ADJ
gs-3446	507	4	factors	factor	NOUN
gs-3446	507	5	●	●	PUNCT
gs-3446	507	6	external	external	ADJ
gs-3446	507	7	factors	factor	NOUN
gs-3446	507	8	such	such	ADJ
gs-3446	507	9	as	as	ADP
gs-3446	507	10	diet	diet	NOUN
gs-3446	507	11	,	,	PUNCT
gs-3446	507	12	stress	stress	NOUN
gs-3446	507	13	,	,	PUNCT
gs-3446	507	14	toxins	toxin	NOUN
gs-3446	507	15	,	,	PUNCT
gs-3446	507	16	and	and	CCONJ
gs-3446	507	17	infections	infection	NOUN
gs-3446	507	18	influence	influence	NOUN
gs-3446	507	19	stem	stem	VERB
gs-3446	507	20	cell	cell	NOUN
gs-3446	507	21	homeostasis	homeostasis	NOUN
gs-3446	507	22	.	.	PUNCT
gs-3446	508	1	●	●	NOUN
gs-3446	508	2	example	example	NOUN
gs-3446	508	3	:	:	PUNCT
gs-3446	508	4	obesity	obesity	NOUN
gs-3446	508	5	-	-	PUNCT
gs-3446	508	6	induced	induce	VERB
gs-3446	508	7	inflammation	inflammation	NOUN
gs-3446	508	8	alters	alter	VERB
gs-3446	508	9	hematopoietic	hematopoietic	ADJ
gs-3446	508	10	stem	stem	NOUN
gs-3446	508	11	cell	cell	NOUN
gs-3446	508	12	function	function	NOUN
gs-3446	508	13	,	,	PUNCT
gs-3446	508	14	predisposing	predispose	VERB
gs-3446	508	15	individuals	individual	NOUN
gs-3446	508	16	to	to	ADP
gs-3446	508	17	metabolic	metabolic	NOUN
gs-3446	508	18	and	and	CCONJ
gs-3446	508	19	immune	immune	ADJ
gs-3446	508	20	disorders	disorder	NOUN
gs-3446	508	21	.	.	PUNCT
gs-3446	509	1	●	●	PUNCT
gs-3446	509	2	systemic	systemic	ADJ
gs-3446	509	3	hormones	hormone	NOUN
gs-3446	509	4	like	like	ADP
gs-3446	509	5	insulin	insulin	NOUN
gs-3446	509	6	,	,	PUNCT
gs-3446	509	7	thyroid	thyroid	NOUN
gs-3446	509	8	hormones	hormone	NOUN
gs-3446	509	9	,	,	PUNCT
gs-3446	509	10	and	and	CCONJ
gs-3446	509	11	glucocorticoids	glucocorticoid	NOUN
gs-3446	509	12	play	play	VERB
gs-3446	509	13	critical	critical	ADJ
gs-3446	509	14	roles	role	NOUN
gs-3446	509	15	in	in	ADP
gs-3446	509	16	regulating	regulate	VERB
gs-3446	509	17	stem	stem	NOUN
gs-3446	509	18	cell	cell	NOUN
gs-3446	509	19	activity	activity	NOUN
gs-3446	509	20	.	.	PUNCT
gs-3446	510	1	georgian	georgian	ADJ
gs-3446	510	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	510	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	510	4	ტ.	ტ.	VERB
gs-3446	510	5	7	7	NUM
gs-3446	510	6	n	n	PRON
gs-3446	510	7	1	1	NUM
gs-3446	510	8	,	,	PUNCT
gs-3446	510	9	2025	2025	NUM
gs-3446	510	10	303	303	NUM
gs-3446	510	11	implications	implication	NOUN
gs-3446	510	12	for	for	ADP
gs-3446	510	13	disease	disease	NOUN
gs-3446	510	14	and	and	CCONJ
gs-3446	510	15	therapy	therapy	NOUN
gs-3446	510	16	understanding	understand	VERB
gs-3446	510	17	the	the	DET
gs-3446	510	18	mechanisms	mechanism	NOUN
gs-3446	510	19	of	of	ADP
gs-3446	510	20	stem	stem	NOUN
gs-3446	510	21	cell	cell	NOUN
gs-3446	510	22	homeostasis	homeostasis	NOUN
gs-3446	510	23	has	have	VERB
gs-3446	510	24	major	major	ADJ
gs-3446	510	25	implications	implication	NOUN
gs-3446	510	26	for	for	ADP
gs-3446	510	27	regenerative	regenerative	ADJ
gs-3446	510	28	medicine	medicine	NOUN
gs-3446	510	29	,	,	PUNCT
gs-3446	510	30	aging	age	VERB
gs-3446	510	31	-	-	PUNCT
gs-3446	510	32	related	relate	VERB
gs-3446	510	33	diseases	disease	NOUN
gs-3446	510	34	,	,	PUNCT
gs-3446	510	35	and	and	CCONJ
gs-3446	510	36	cancer	cancer	NOUN
gs-3446	510	37	therapy	therapy	NOUN
gs-3446	510	38	(	(	PUNCT
gs-3446	510	39	aphkhazava	aphkhazava	NOUN
gs-3446	510	40	et	et	PROPN
gs-3446	510	41	al	al	PROPN
gs-3446	510	42	.	.	PROPN
gs-3446	510	43	2024	2024	NUM
gs-3446	510	44	)	)	PUNCT
gs-3446	510	45	.	.	PUNCT
gs-3446	511	1	regenerative	regenerative	ADJ
gs-3446	511	2	medicine	medicine	NOUN
gs-3446	511	3	and	and	CCONJ
gs-3446	511	4	stem	stem	NOUN
gs-3446	511	5	cell	cell	NOUN
gs-3446	511	6	therapies	therapy	NOUN
gs-3446	511	7	●	●	NUM
gs-3446	511	8	stem	stem	NOUN
gs-3446	511	9	cell	cell	NOUN
gs-3446	511	10	-	-	PUNCT
gs-3446	511	11	based	base	VERB
gs-3446	511	12	therapies	therapy	NOUN
gs-3446	511	13	aim	aim	VERB
gs-3446	511	14	to	to	PART
gs-3446	511	15	restore	restore	VERB
gs-3446	511	16	tissue	tissue	NOUN
gs-3446	511	17	function	function	NOUN
gs-3446	511	18	in	in	ADP
gs-3446	511	19	degenerative	degenerative	ADJ
gs-3446	511	20	diseases	disease	NOUN
gs-3446	511	21	,	,	PUNCT
gs-3446	511	22	injuries	injury	NOUN
gs-3446	511	23	,	,	PUNCT
gs-3446	511	24	and	and	CCONJ
gs-3446	511	25	genetic	genetic	ADJ
gs-3446	511	26	disorders	disorder	NOUN
gs-3446	511	27	.	.	PUNCT
gs-3446	512	1	●	●	PUNCT
gs-3446	512	2	induced	induce	VERB
gs-3446	512	3	pluripotent	pluripotent	ADJ
gs-3446	512	4	stem	stem	NOUN
gs-3446	512	5	cells	cell	NOUN
gs-3446	512	6	(	(	PUNCT
gs-3446	512	7	ipscs	ipsc	NOUN
gs-3446	512	8	)	)	PUNCT
gs-3446	512	9	provide	provide	VERB
gs-3446	512	10	patient	patient	NOUN
gs-3446	512	11	-	-	PUNCT
gs-3446	512	12	specific	specific	ADJ
gs-3446	512	13	,	,	PUNCT
gs-3446	512	14	ethically	ethically	ADV
gs-3446	512	15	viable	viable	ADJ
gs-3446	512	16	alternatives	alternative	NOUN
gs-3446	512	17	for	for	ADP
gs-3446	512	18	regenerative	regenerative	ADJ
gs-3446	512	19	medicine	medicine	NOUN
gs-3446	512	20	.	.	PUNCT
gs-3446	513	1	●	●	PUNCT
gs-3446	513	2	biomaterials	biomaterial	NOUN
gs-3446	513	3	and	and	CCONJ
gs-3446	513	4	artificial	artificial	ADJ
gs-3446	513	5	niches	niche	NOUN
gs-3446	513	6	are	be	AUX
gs-3446	513	7	being	be	AUX
gs-3446	513	8	developed	develop	VERB
gs-3446	513	9	to	to	PART
gs-3446	513	10	enhance	enhance	VERB
gs-3446	513	11	the	the	DET
gs-3446	513	12	survival	survival	NOUN
gs-3446	513	13	and	and	CCONJ
gs-3446	513	14	integration	integration	NOUN
gs-3446	513	15	of	of	ADP
gs-3446	513	16	transplanted	transplanted	ADJ
gs-3446	513	17	stem	stem	NOUN
gs-3446	513	18	cells	cell	NOUN
gs-3446	513	19	.	.	PUNCT
gs-3446	514	1	anti	anti	ADJ
gs-3446	514	2	-	-	ADJ
gs-3446	514	3	aging	aging	ADJ
gs-3446	514	4	and	and	CCONJ
gs-3446	514	5	longevity	longevity	NOUN
gs-3446	514	6	research	research	NOUN
gs-3446	514	7	●	●	NUM
gs-3446	514	8	targeting	target	VERB
gs-3446	514	9	stem	stem	NOUN
gs-3446	514	10	cell	cell	NOUN
gs-3446	514	11	aging	aging	NOUN
gs-3446	514	12	is	be	AUX
gs-3446	514	13	a	a	DET
gs-3446	514	14	promising	promising	ADJ
gs-3446	514	15	approach	approach	NOUN
gs-3446	514	16	for	for	ADP
gs-3446	514	17	extending	extend	VERB
gs-3446	514	18	healthy	healthy	ADJ
gs-3446	514	19	lifespan	lifespan	NOUN
gs-3446	514	20	.	.	PUNCT
gs-3446	515	1	●	●	NUM
gs-3446	515	2	strategies	strategy	NOUN
gs-3446	515	3	include	include	VERB
gs-3446	515	4	:	:	PUNCT
gs-3446	515	5	○	○	ADJ
gs-3446	515	6	metabolic	metabolic	NOUN
gs-3446	515	7	reprogramming	reprogramme	VERB
gs-3446	515	8	(	(	PUNCT
gs-3446	515	9	e.g.	e.g.	ADV
gs-3446	515	10	,	,	PUNCT
gs-3446	515	11	nad+	nad+	PROPN
gs-3446	515	12	boosters	booster	NOUN
gs-3446	515	13	,	,	PUNCT
gs-3446	515	14	calorie	calorie	NOUN
gs-3446	515	15	restriction	restriction	NOUN
gs-3446	515	16	mimetics	mimetic	NOUN
gs-3446	515	17	)	)	PUNCT
gs-3446	515	18	.	.	PUNCT
gs-3446	516	1	○	○	ADJ
gs-3446	516	2	epigenetic	epigenetic	ADJ
gs-3446	516	3	rejuvenation	rejuvenation	NOUN
gs-3446	516	4	using	use	VERB
gs-3446	516	5	yamanaka	yamanaka	PROPN
gs-3446	516	6	factors	factor	NOUN
gs-3446	516	7	(	(	PUNCT
gs-3446	516	8	oct4	oct4	NOUN
gs-3446	516	9	,	,	PUNCT
gs-3446	516	10	sox2	sox2	NOUN
gs-3446	516	11	,	,	PUNCT
gs-3446	516	12	klf4	klf4	NOUN
gs-3446	516	13	,	,	PUNCT
gs-3446	516	14	c	c	NOUN
gs-3446	516	15	-	-	PUNCT
gs-3446	516	16	myc	myc	NOUN
gs-3446	516	17	)	)	PUNCT
gs-3446	516	18	.	.	PUNCT
gs-3446	517	1	○	○	ADJ
gs-3446	517	2	stem	stem	NOUN
gs-3446	517	3	cell	cell	NOUN
gs-3446	517	4	transplantation	transplantation	NOUN
gs-3446	517	5	to	to	PART
gs-3446	517	6	replace	replace	VERB
gs-3446	517	7	aged	aged	ADJ
gs-3446	517	8	or	or	CCONJ
gs-3446	517	9	dysfunctional	dysfunctional	ADJ
gs-3446	517	10	stem	stem	NOUN
gs-3446	517	11	cell	cell	NOUN
gs-3446	517	12	populations	population	NOUN
gs-3446	517	13	.	.	PUNCT
gs-3446	518	1	cancer	cancer	NOUN
gs-3446	518	2	therapy	therapy	NOUN
gs-3446	518	3	and	and	CCONJ
gs-3446	518	4	targeting	target	VERB
gs-3446	518	5	cancer	cancer	NOUN
gs-3446	518	6	stem	stem	NOUN
gs-3446	518	7	cells	cell	NOUN
gs-3446	518	8	(	(	PUNCT
gs-3446	518	9	cscs	cscs	PROPN
gs-3446	518	10	)	)	PUNCT
gs-3446	518	11	●	●	X
gs-3446	518	12	eradicating	eradicate	VERB
gs-3446	518	13	cscs	cscs	NOUN
gs-3446	518	14	is	be	AUX
gs-3446	518	15	critical	critical	ADJ
gs-3446	518	16	for	for	ADP
gs-3446	518	17	preventing	prevent	VERB
gs-3446	518	18	relapse	relapse	NOUN
gs-3446	518	19	and	and	CCONJ
gs-3446	518	20	improving	improve	VERB
gs-3446	518	21	cancer	cancer	NOUN
gs-3446	518	22	treatment	treatment	NOUN
gs-3446	518	23	outcomes	outcome	NOUN
gs-3446	518	24	.	.	PUNCT
gs-3446	519	1	●	●	PUNCT
gs-3446	519	2	therapies	therapy	NOUN
gs-3446	519	3	targeting	target	VERB
gs-3446	519	4	csc	csc	ADJ
gs-3446	519	5	-	-	PUNCT
gs-3446	519	6	specific	specific	ADJ
gs-3446	519	7	pathways	pathway	NOUN
gs-3446	519	8	include	include	VERB
gs-3446	519	9	:	:	PUNCT
gs-3446	519	10	○	○	ADJ
gs-3446	519	11	wnt	wnt	NOUN
gs-3446	519	12	and	and	CCONJ
gs-3446	519	13	notch	notch	VERB
gs-3446	519	14	inhibitors	inhibitor	NOUN
gs-3446	519	15	to	to	PART
gs-3446	519	16	block	block	VERB
gs-3446	519	17	self	self	NOUN
gs-3446	519	18	-	-	PUNCT
gs-3446	519	19	renewal	renewal	NOUN
gs-3446	519	20	.	.	PUNCT
gs-3446	520	1	○	○	ADJ
gs-3446	520	2	epigenetic	epigenetic	ADJ
gs-3446	520	3	drugs	drug	NOUN
gs-3446	520	4	to	to	PART
gs-3446	520	5	restore	restore	VERB
gs-3446	520	6	normal	normal	ADJ
gs-3446	520	7	differentiation	differentiation	NOUN
gs-3446	520	8	patterns	pattern	NOUN
gs-3446	520	9	.	.	PUNCT
gs-3446	521	1	○	○	ADJ
gs-3446	521	2	immunotherapy	immunotherapy	NOUN
gs-3446	521	3	to	to	PART
gs-3446	521	4	selectively	selectively	ADV
gs-3446	521	5	eliminate	eliminate	VERB
gs-3446	521	6	cscs	cscs	NOUN
gs-3446	521	7	.	.	PUNCT
gs-3446	522	1	future	future	ADJ
gs-3446	522	2	directions	direction	NOUN
gs-3446	522	3	and	and	CCONJ
gs-3446	522	4	challenges	challenge	NOUN
gs-3446	522	5	despite	despite	SCONJ
gs-3446	522	6	significant	significant	ADJ
gs-3446	522	7	progress	progress	NOUN
gs-3446	522	8	in	in	ADP
gs-3446	522	9	stem	stem	NOUN
gs-3446	522	10	cell	cell	NOUN
gs-3446	522	11	research	research	NOUN
gs-3446	522	12	,	,	PUNCT
gs-3446	522	13	challenges	challenge	NOUN
gs-3446	522	14	remain	remain	VERB
gs-3446	522	15	in	in	ADP
gs-3446	522	16	fully	fully	ADV
gs-3446	522	17	understanding	understanding	NOUN
gs-3446	522	18	and	and	CCONJ
gs-3446	522	19	manipulating	manipulate	VERB
gs-3446	522	20	stem	stem	NOUN
gs-3446	522	21	cell	cell	NOUN
gs-3446	522	22	homeostasis	homeostasis	NOUN
gs-3446	522	23	for	for	ADP
gs-3446	522	24	therapeutic	therapeutic	ADJ
gs-3446	522	25	applications	application	NOUN
gs-3446	522	26	.	.	PUNCT
gs-3446	523	1	ethical	ethical	ADJ
gs-3446	523	2	and	and	CCONJ
gs-3446	523	3	safety	safety	NOUN
gs-3446	523	4	considerations	consideration	NOUN
gs-3446	523	5	●	●	PUNCT
gs-3446	523	6	the	the	DET
gs-3446	523	7	use	use	NOUN
gs-3446	523	8	of	of	ADP
gs-3446	523	9	embryonic	embryonic	ADJ
gs-3446	523	10	stem	stem	NOUN
gs-3446	523	11	cells	cell	NOUN
gs-3446	523	12	(	(	PUNCT
gs-3446	523	13	escs	esc	NOUN
gs-3446	523	14	)	)	PUNCT
gs-3446	523	15	raises	raise	VERB
gs-3446	523	16	ethical	ethical	ADJ
gs-3446	523	17	concerns	concern	NOUN
gs-3446	523	18	,	,	PUNCT
gs-3446	523	19	while	while	SCONJ
gs-3446	523	20	ipsc	ipsc	NOUN
gs-3446	523	21	-	-	PUNCT
gs-3446	523	22	based	base	VERB
gs-3446	523	23	therapies	therapy	NOUN
gs-3446	523	24	require	require	VERB
gs-3446	523	25	further	further	ADJ
gs-3446	523	26	validation	validation	NOUN
gs-3446	523	27	to	to	PART
gs-3446	523	28	ensure	ensure	VERB
gs-3446	523	29	safety	safety	NOUN
gs-3446	523	30	and	and	CCONJ
gs-3446	523	31	efficacy	efficacy	NOUN
gs-3446	523	32	.	.	PUNCT
gs-3446	524	1	georgian	georgian	ADJ
gs-3446	524	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	524	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	524	4	ტ.	ტ.	VERB
gs-3446	524	5	7	7	NUM
gs-3446	524	6	n	n	DET
gs-3446	524	7	1	1	NUM
gs-3446	524	8	,	,	PUNCT
gs-3446	524	9	2025	2025	NUM
gs-3446	524	10	304	304	NUM
gs-3446	524	11	●	●	NUM
gs-3446	524	12	the	the	DET
gs-3446	524	13	risk	risk	NOUN
gs-3446	524	14	of	of	ADP
gs-3446	524	15	tumorigenesis	tumorigenesis	NOUN
gs-3446	524	16	in	in	ADP
gs-3446	524	17	stem	stem	NOUN
gs-3446	524	18	cell	cell	NOUN
gs-3446	524	19	therapies	therapy	NOUN
gs-3446	524	20	needs	need	VERB
gs-3446	524	21	to	to	PART
gs-3446	524	22	be	be	AUX
gs-3446	524	23	carefully	carefully	ADV
gs-3446	524	24	managed	manage	VERB
gs-3446	524	25	.	.	PUNCT
gs-3446	525	1	long	long	ADJ
gs-3446	525	2	-	-	PUNCT
gs-3446	525	3	term	term	NOUN
gs-3446	525	4	integration	integration	NOUN
gs-3446	525	5	and	and	CCONJ
gs-3446	525	6	functional	functional	ADJ
gs-3446	525	7	recovery	recovery	NOUN
gs-3446	525	8	●	●	PUNCT
gs-3446	525	9	ensuring	ensure	VERB
gs-3446	525	10	that	that	SCONJ
gs-3446	525	11	transplanted	transplanted	ADJ
gs-3446	525	12	stem	stem	NOUN
gs-3446	525	13	cells	cell	NOUN
gs-3446	525	14	properly	properly	ADV
gs-3446	525	15	integrate	integrate	VERB
gs-3446	525	16	into	into	ADP
gs-3446	525	17	host	host	NOUN
gs-3446	525	18	tissues	tissue	NOUN
gs-3446	525	19	and	and	CCONJ
gs-3446	525	20	perform	perform	VERB
gs-3446	525	21	their	their	PRON
gs-3446	525	22	intended	intend	VERB
gs-3446	525	23	functions	function	NOUN
gs-3446	525	24	remains	remain	VERB
gs-3446	525	25	a	a	DET
gs-3446	525	26	challenge	challenge	NOUN
gs-3446	525	27	.	.	PUNCT
gs-3446	526	1	●	●	PUNCT
gs-3446	526	2	research	research	NOUN
gs-3446	526	3	is	be	AUX
gs-3446	526	4	ongoing	ongoing	ADJ
gs-3446	526	5	to	to	PART
gs-3446	526	6	optimize	optimize	VERB
gs-3446	526	7	biomaterial	biomaterial	ADJ
gs-3446	526	8	scaffolds	scaffold	NOUN
gs-3446	526	9	,	,	PUNCT
gs-3446	526	10	niche	niche	NOUN
gs-3446	526	11	engineering	engineering	NOUN
gs-3446	526	12	,	,	PUNCT
gs-3446	526	13	and	and	CCONJ
gs-3446	526	14	immunomodulation	immunomodulation	NOUN
gs-3446	526	15	strategies	strategy	NOUN
gs-3446	526	16	for	for	ADP
gs-3446	526	17	improved	improved	ADJ
gs-3446	526	18	transplantation	transplantation	NOUN
gs-3446	526	19	outcomes	outcome	NOUN
gs-3446	526	20	.	.	PUNCT
gs-3446	527	1	personalized	personalized	ADJ
gs-3446	527	2	and	and	CCONJ
gs-3446	527	3	precision	precision	NOUN
gs-3446	527	4	medicine	medicine	NOUN
gs-3446	527	5	approaches	approach	VERB
gs-3446	527	6	●	●	NOUN
gs-3446	527	7	advances	advance	NOUN
gs-3446	527	8	in	in	ADP
gs-3446	527	9	single	single	ADJ
gs-3446	527	10	-	-	PUNCT
gs-3446	527	11	cell	cell	NOUN
gs-3446	527	12	sequencing	sequencing	NOUN
gs-3446	527	13	,	,	PUNCT
gs-3446	527	14	organoid	organoid	NOUN
gs-3446	527	15	technology	technology	NOUN
gs-3446	527	16	,	,	PUNCT
gs-3446	527	17	and	and	CCONJ
gs-3446	527	18	ai	ai	AUX
gs-3446	527	19	-	-	PUNCT
gs-3446	527	20	driven	drive	VERB
gs-3446	527	21	drug	drug	NOUN
gs-3446	527	22	discovery	discovery	NOUN
gs-3446	527	23	are	be	AUX
gs-3446	527	24	enhancing	enhance	VERB
gs-3446	527	25	our	our	PRON
gs-3446	527	26	ability	ability	NOUN
gs-3446	527	27	to	to	PART
gs-3446	527	28	predict	predict	VERB
gs-3446	527	29	,	,	PUNCT
gs-3446	527	30	monitor	monitor	VERB
gs-3446	527	31	,	,	PUNCT
gs-3446	527	32	and	and	CCONJ
gs-3446	527	33	tailor	tailor	NOUN
gs-3446	527	34	stem	stem	NOUN
gs-3446	527	35	cell	cell	NOUN
gs-3446	527	36	therapies	therapy	NOUN
gs-3446	527	37	for	for	ADP
gs-3446	527	38	individual	individual	ADJ
gs-3446	527	39	patients	patient	NOUN
gs-3446	527	40	.	.	PUNCT
gs-3446	528	1	●	●	PUNCT
gs-3446	528	2	gene	gene	NOUN
gs-3446	528	3	editing	editing	NOUN
gs-3446	528	4	technologies	technology	NOUN
gs-3446	528	5	(	(	PUNCT
gs-3446	528	6	e.g.	e.g.	ADV
gs-3446	528	7	,	,	PUNCT
gs-3446	528	8	crispr	crispr	ADJ
gs-3446	528	9	/	/	SYM
gs-3446	528	10	cas9	cas9	NOUN
gs-3446	528	11	)	)	PUNCT
gs-3446	528	12	offer	offer	VERB
gs-3446	528	13	promising	promise	VERB
gs-3446	528	14	solutions	solution	NOUN
gs-3446	528	15	for	for	ADP
gs-3446	528	16	correcting	correct	VERB
gs-3446	528	17	genetic	genetic	ADJ
gs-3446	528	18	defects	defect	NOUN
gs-3446	528	19	in	in	ADP
gs-3446	528	20	stem	stem	NOUN
gs-3446	528	21	cells	cell	NOUN
gs-3446	528	22	before	before	ADP
gs-3446	528	23	transplantation	transplantation	NOUN
gs-3446	528	24	(	(	PUNCT
gs-3446	528	25	clevers	clever	NOUN
gs-3446	528	26	et	et	PROPN
gs-3446	528	27	al	al	PROPN
gs-3446	528	28	.	.	PROPN
gs-3446	528	29	2011	2011	NUM
gs-3446	528	30	)	)	PUNCT
gs-3446	528	31	.	.	PUNCT
gs-3446	529	1	stem	stem	NOUN
gs-3446	529	2	cell	cell	NOUN
gs-3446	529	3	homeostasis	homeostasis	NOUN
gs-3446	529	4	is	be	AUX
gs-3446	529	5	a	a	DET
gs-3446	529	6	tightly	tightly	ADV
gs-3446	529	7	controlled	control	VERB
gs-3446	529	8	process	process	NOUN
gs-3446	529	9	that	that	PRON
gs-3446	529	10	ensures	ensure	VERB
gs-3446	529	11	the	the	DET
gs-3446	529	12	long	long	ADJ
gs-3446	529	13	-	-	PUNCT
gs-3446	529	14	term	term	NOUN
gs-3446	529	15	maintenance	maintenance	NOUN
gs-3446	529	16	and	and	CCONJ
gs-3446	529	17	functionality	functionality	NOUN
gs-3446	529	18	of	of	ADP
gs-3446	529	19	tissues	tissue	NOUN
gs-3446	529	20	.	.	PUNCT
gs-3446	530	1	disruptions	disruption	NOUN
gs-3446	530	2	in	in	ADP
gs-3446	530	3	homeostasis	homeostasis	NOUN
gs-3446	530	4	contribute	contribute	NOUN
gs-3446	530	5	to	to	ADP
gs-3446	530	6	aging	age	VERB
gs-3446	530	7	,	,	PUNCT
gs-3446	530	8	degenerative	degenerative	ADJ
gs-3446	530	9	diseases	disease	NOUN
gs-3446	530	10	,	,	PUNCT
gs-3446	530	11	and	and	CCONJ
gs-3446	530	12	cancer	cancer	NOUN
gs-3446	530	13	,	,	PUNCT
gs-3446	530	14	highlighting	highlight	VERB
gs-3446	530	15	the	the	DET
gs-3446	530	16	need	need	NOUN
gs-3446	530	17	for	for	ADP
gs-3446	530	18	targeted	target	VERB
gs-3446	530	19	interventions	intervention	NOUN
gs-3446	530	20	.	.	PUNCT
gs-3446	531	1	while	while	SCONJ
gs-3446	531	2	stem	stem	NOUN
gs-3446	531	3	cell	cell	NOUN
gs-3446	531	4	-	-	PUNCT
gs-3446	531	5	based	base	VERB
gs-3446	531	6	therapies	therapy	NOUN
gs-3446	531	7	and	and	CCONJ
gs-3446	531	8	regenerative	regenerative	ADJ
gs-3446	531	9	medicine	medicine	NOUN
gs-3446	531	10	offer	offer	NOUN
gs-3446	531	11	promising	promising	ADJ
gs-3446	531	12	solutions	solution	NOUN
gs-3446	531	13	,	,	PUNCT
gs-3446	531	14	challenges	challenge	NOUN
gs-3446	531	15	related	relate	VERB
gs-3446	531	16	to	to	ADP
gs-3446	531	17	tumorigenic	tumorigenic	ADJ
gs-3446	531	18	risks	risk	NOUN
gs-3446	531	19	,	,	PUNCT
gs-3446	531	20	ethical	ethical	ADJ
gs-3446	531	21	concerns	concern	NOUN
gs-3446	531	22	,	,	PUNCT
gs-3446	531	23	and	and	CCONJ
gs-3446	531	24	long	long	ADJ
gs-3446	531	25	-	-	PUNCT
gs-3446	531	26	term	term	NOUN
gs-3446	531	27	integration	integration	NOUN
gs-3446	531	28	must	must	AUX
gs-3446	531	29	be	be	AUX
gs-3446	531	30	addressed	address	VERB
gs-3446	531	31	.	.	PUNCT
gs-3446	532	1	future	future	ADJ
gs-3446	532	2	research	research	NOUN
gs-3446	532	3	should	should	AUX
gs-3446	532	4	focus	focus	VERB
gs-3446	532	5	on	on	ADP
gs-3446	532	6	refining	refine	VERB
gs-3446	532	7	gene	gene	NOUN
gs-3446	532	8	editing	edit	VERB
gs-3446	532	9	techniques	technique	NOUN
gs-3446	532	10	,	,	PUNCT
gs-3446	532	11	developing	develop	VERB
gs-3446	532	12	artificial	artificial	ADJ
gs-3446	532	13	niches	niche	NOUN
gs-3446	532	14	,	,	PUNCT
gs-3446	532	15	and	and	CCONJ
gs-3446	532	16	leveraging	leverage	VERB
gs-3446	532	17	personalized	personalized	ADJ
gs-3446	532	18	medicine	medicine	NOUN
gs-3446	532	19	approaches	approach	NOUN
gs-3446	532	20	to	to	PART
gs-3446	532	21	optimize	optimize	VERB
gs-3446	532	22	stem	stem	NOUN
gs-3446	532	23	cell	cell	NOUN
gs-3446	532	24	therapies	therapy	NOUN
gs-3446	532	25	for	for	ADP
gs-3446	532	26	diverse	diverse	ADJ
gs-3446	532	27	medical	medical	ADJ
gs-3446	532	28	applications	application	NOUN
gs-3446	532	29	.	.	PUNCT
gs-3446	533	1	signals	signal	NOUN
gs-3446	533	2	affecting	affect	VERB
gs-3446	533	3	stem	stem	NOUN
gs-3446	533	4	cells	cell	NOUN
gs-3446	533	5	division	division	NOUN
gs-3446	533	6	stem	stem	NOUN
gs-3446	533	7	cell	cell	NOUN
gs-3446	533	8	division	division	NOUN
gs-3446	533	9	is	be	AUX
gs-3446	533	10	a	a	DET
gs-3446	533	11	tightly	tightly	ADV
gs-3446	533	12	regulated	regulate	VERB
gs-3446	533	13	process	process	NOUN
gs-3446	533	14	that	that	PRON
gs-3446	533	15	ensures	ensure	VERB
gs-3446	533	16	the	the	DET
gs-3446	533	17	balance	balance	NOUN
gs-3446	533	18	between	between	ADP
gs-3446	533	19	self	self	NOUN
gs-3446	533	20	-	-	PUNCT
gs-3446	533	21	renewal	renewal	NOUN
gs-3446	533	22	and	and	CCONJ
gs-3446	533	23	differentiation	differentiation	NOUN
gs-3446	533	24	.	.	PUNCT
gs-3446	534	1	this	this	DET
gs-3446	534	2	balance	balance	NOUN
gs-3446	534	3	is	be	AUX
gs-3446	534	4	critical	critical	ADJ
gs-3446	534	5	for	for	ADP
gs-3446	534	6	tissue	tissue	NOUN
gs-3446	534	7	maintenance	maintenance	NOUN
gs-3446	534	8	,	,	PUNCT
gs-3446	534	9	repair	repair	NOUN
gs-3446	534	10	,	,	PUNCT
gs-3446	534	11	and	and	CCONJ
gs-3446	534	12	regeneration	regeneration	NOUN
gs-3446	534	13	.	.	PUNCT
gs-3446	535	1	the	the	DET
gs-3446	535	2	regulation	regulation	NOUN
gs-3446	535	3	of	of	ADP
gs-3446	535	4	stem	stem	NOUN
gs-3446	535	5	cell	cell	NOUN
gs-3446	535	6	division	division	NOUN
gs-3446	535	7	is	be	AUX
gs-3446	535	8	influenced	influence	VERB
gs-3446	535	9	by	by	ADP
gs-3446	535	10	a	a	DET
gs-3446	535	11	complex	complex	ADJ
gs-3446	535	12	interplay	interplay	NOUN
gs-3446	535	13	of	of	ADP
gs-3446	535	14	intrinsic	intrinsic	ADJ
gs-3446	535	15	and	and	CCONJ
gs-3446	535	16	extrinsic	extrinsic	ADJ
gs-3446	535	17	signals	signal	NOUN
gs-3446	535	18	,	,	PUNCT
gs-3446	535	19	including	include	VERB
gs-3446	535	20	growth	growth	NOUN
gs-3446	535	21	factors	factor	NOUN
gs-3446	535	22	,	,	PUNCT
gs-3446	535	23	cytokines	cytokine	NOUN
gs-3446	535	24	,	,	PUNCT
gs-3446	535	25	and	and	CCONJ
gs-3446	535	26	physical	physical	ADJ
gs-3446	535	27	cues	cue	NOUN
gs-3446	535	28	from	from	ADP
gs-3446	535	29	the	the	DET
gs-3446	535	30	microenvironment	microenvironment	NOUN
gs-3446	535	31	.	.	PUNCT
gs-3446	536	1	understanding	understand	VERB
gs-3446	536	2	these	these	DET
gs-3446	536	3	signals	signal	NOUN
gs-3446	536	4	is	be	AUX
gs-3446	536	5	essential	essential	ADJ
gs-3446	536	6	for	for	ADP
gs-3446	536	7	advancing	advance	VERB
gs-3446	536	8	stem	stem	NOUN
gs-3446	536	9	cell	cell	NOUN
gs-3446	536	10	biology	biology	NOUN
gs-3446	536	11	and	and	CCONJ
gs-3446	536	12	developing	develop	VERB
gs-3446	536	13	therapeutic	therapeutic	ADJ
gs-3446	536	14	strategies	strategy	NOUN
gs-3446	536	15	.	.	PUNCT
gs-3446	537	1	key	key	ADJ
gs-3446	537	2	signaling	signal	VERB
gs-3446	537	3	pathways	pathway	NOUN
gs-3446	537	4	regulating	regulate	VERB
gs-3446	537	5	stem	stem	NOUN
gs-3446	537	6	cell	cell	NOUN
gs-3446	537	7	division	division	NOUN
gs-3446	537	8	1	1	NUM
gs-3446	537	9	.	.	PUNCT
gs-3446	538	1	wnt	wnt	PROPN
gs-3446	538	2	/	/	SYM
gs-3446	538	3	β	β	NOUN
gs-3446	538	4	-	-	ADJ
gs-3446	538	5	catenin	catenin	ADJ
gs-3446	538	6	pathway	pathway	NOUN
gs-3446	538	7	:	:	PUNCT
gs-3446	538	8	○	○	ADJ
gs-3446	538	9	role	role	NOUN
gs-3446	538	10	:	:	PUNCT
gs-3446	538	11	the	the	DET
gs-3446	538	12	wnt	wnt	PROPN
gs-3446	538	13	/	/	SYM
gs-3446	538	14	β	β	NOUN
gs-3446	538	15	-	-	ADJ
gs-3446	538	16	catenin	catenin	ADJ
gs-3446	538	17	pathway	pathway	NOUN
gs-3446	538	18	is	be	AUX
gs-3446	538	19	a	a	DET
gs-3446	538	20	critical	critical	ADJ
gs-3446	538	21	regulator	regulator	NOUN
gs-3446	538	22	of	of	ADP
gs-3446	538	23	stem	stem	NOUN
gs-3446	538	24	cell	cell	NOUN
gs-3446	538	25	self	self	NOUN
gs-3446	538	26	-	-	PUNCT
gs-3446	538	27	renewal	renewal	NOUN
gs-3446	538	28	and	and	CCONJ
gs-3446	538	29	proliferation	proliferation	NOUN
gs-3446	538	30	.	.	PUNCT
gs-3446	539	1	activation	activation	NOUN
gs-3446	539	2	of	of	ADP
gs-3446	539	3	wnt	wnt	NOUN
gs-3446	539	4	signaling	signal	VERB
gs-3446	539	5	promotes	promote	VERB
gs-3446	539	6	the	the	DET
gs-3446	539	7	stabilization	stabilization	NOUN
gs-3446	539	8	and	and	CCONJ
gs-3446	539	9	nuclear	nuclear	ADJ
gs-3446	539	10	translocation	translocation	NOUN
gs-3446	539	11	of	of	ADP
gs-3446	539	12	β	β	NOUN
gs-3446	539	13	-	-	NOUN
gs-3446	539	14	catenin	catenin	NOUN
gs-3446	539	15	,	,	PUNCT
gs-3446	539	16	which	which	PRON
gs-3446	539	17	then	then	ADV
gs-3446	539	18	activates	activate	VERB
gs-3446	539	19	target	target	NOUN
gs-3446	539	20	genes	gene	NOUN
gs-3446	539	21	involved	involve	VERB
gs-3446	539	22	in	in	ADP
gs-3446	539	23	cell	cell	NOUN
gs-3446	539	24	cycle	cycle	NOUN
gs-3446	539	25	progression	progression	NOUN
gs-3446	539	26	and	and	CCONJ
gs-3446	539	27	stem	stem	NOUN
gs-3446	539	28	cell	cell	NOUN
gs-3446	539	29	maintenance	maintenance	NOUN
gs-3446	539	30	.	.	PUNCT
gs-3446	540	1	georgian	georgian	ADJ
gs-3446	540	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	540	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	540	4	ტ.	ტ.	VERB
gs-3446	540	5	7	7	NUM
gs-3446	540	6	n	n	PRON
gs-3446	540	7	1	1	NUM
gs-3446	540	8	,	,	PUNCT
gs-3446	540	9	2025	2025	NUM
gs-3446	540	10	305	305	NUM
gs-3446	540	11	○	○	ADJ
gs-3446	540	12	examples	example	NOUN
gs-3446	540	13	:	:	PUNCT
gs-3446	540	14	in	in	ADP
gs-3446	540	15	intestinal	intestinal	ADJ
gs-3446	540	16	stem	stem	NOUN
gs-3446	540	17	cells	cell	NOUN
gs-3446	540	18	,	,	PUNCT
gs-3446	540	19	wnt	wnt	NOUN
gs-3446	540	20	signaling	signal	VERB
gs-3446	540	21	is	be	AUX
gs-3446	540	22	essential	essential	ADJ
gs-3446	540	23	for	for	ADP
gs-3446	540	24	maintaining	maintain	VERB
gs-3446	540	25	the	the	DET
gs-3446	540	26	stem	stem	NOUN
gs-3446	540	27	cell	cell	NOUN
gs-3446	540	28	pool	pool	NOUN
gs-3446	540	29	and	and	CCONJ
gs-3446	540	30	driving	drive	VERB
gs-3446	540	31	proliferation	proliferation	NOUN
gs-3446	540	32	.	.	PUNCT
gs-3446	541	1	dysregulation	dysregulation	NOUN
gs-3446	541	2	of	of	ADP
gs-3446	541	3	this	this	DET
gs-3446	541	4	pathway	pathway	NOUN
gs-3446	541	5	is	be	AUX
gs-3446	541	6	associated	associate	VERB
gs-3446	541	7	with	with	ADP
gs-3446	541	8	cancer	cancer	NOUN
gs-3446	541	9	,	,	PUNCT
gs-3446	541	10	particularly	particularly	ADV
gs-3446	541	11	colorectal	colorectal	ADJ
gs-3446	541	12	cancer	cancer	NOUN
gs-3446	541	13	.	.	PUNCT
gs-3446	542	1	2	2	X
gs-3446	542	2	.	.	X
gs-3446	542	3	notch	notch	ADJ
gs-3446	542	4	signaling	signal	VERB
gs-3446	542	5	:	:	PUNCT
gs-3446	542	6	○	○	ADJ
gs-3446	542	7	role	role	NOUN
gs-3446	542	8	:	:	PUNCT
gs-3446	542	9	notch	notch	ADJ
gs-3446	542	10	signaling	signal	VERB
gs-3446	542	11	plays	play	VERB
gs-3446	542	12	a	a	DET
gs-3446	542	13	key	key	ADJ
gs-3446	542	14	role	role	NOUN
gs-3446	542	15	in	in	ADP
gs-3446	542	16	cell	cell	NOUN
gs-3446	542	17	fate	fate	NOUN
gs-3446	542	18	decisions	decision	NOUN
gs-3446	542	19	,	,	PUNCT
gs-3446	542	20	including	include	VERB
gs-3446	542	21	stem	stem	NOUN
gs-3446	542	22	cell	cell	NOUN
gs-3446	542	23	selfrenewal	selfrenewal	NOUN
gs-3446	542	24	and	and	CCONJ
gs-3446	542	25	differentiation	differentiation	NOUN
gs-3446	542	26	.	.	PUNCT
gs-3446	543	1	activation	activation	NOUN
gs-3446	543	2	of	of	ADP
gs-3446	543	3	notch	notch	ADJ
gs-3446	543	4	receptors	receptor	NOUN
gs-3446	543	5	by	by	ADP
gs-3446	543	6	their	their	PRON
gs-3446	543	7	ligands	ligand	NOUN
gs-3446	543	8	(	(	PUNCT
gs-3446	543	9	e.g.	e.g.	ADJ
gs-3446	543	10	,	,	PUNCT
gs-3446	543	11	delta	delta	NOUN
gs-3446	543	12	,	,	PUNCT
gs-3446	543	13	jagged	jagged	ADJ
gs-3446	543	14	)	)	PUNCT
gs-3446	543	15	leads	lead	VERB
gs-3446	543	16	to	to	ADP
gs-3446	543	17	the	the	DET
gs-3446	543	18	cleavage	cleavage	NOUN
gs-3446	543	19	of	of	ADP
gs-3446	543	20	the	the	DET
gs-3446	543	21	notch	notch	ADJ
gs-3446	543	22	intracellular	intracellular	ADJ
gs-3446	543	23	domain	domain	NOUN
gs-3446	543	24	(	(	PUNCT
gs-3446	543	25	nicd	nicd	NOUN
gs-3446	543	26	)	)	PUNCT
gs-3446	543	27	,	,	PUNCT
gs-3446	543	28	which	which	PRON
gs-3446	543	29	translocates	translocate	VERB
gs-3446	543	30	to	to	ADP
gs-3446	543	31	the	the	DET
gs-3446	543	32	nucleus	nucleus	NOUN
gs-3446	543	33	to	to	PART
gs-3446	543	34	activate	activate	VERB
gs-3446	543	35	target	target	NOUN
gs-3446	543	36	genes	gene	NOUN
gs-3446	543	37	.	.	PUNCT
gs-3446	544	1	○	○	ADJ
gs-3446	544	2	examples	example	NOUN
gs-3446	544	3	:	:	PUNCT
gs-3446	544	4	in	in	ADP
gs-3446	544	5	hematopoietic	hematopoietic	ADJ
gs-3446	544	6	stem	stem	NOUN
gs-3446	544	7	cells	cell	NOUN
gs-3446	544	8	(	(	PUNCT
gs-3446	544	9	hscs	hsc	NOUN
gs-3446	544	10	)	)	PUNCT
gs-3446	544	11	,	,	PUNCT
gs-3446	544	12	notch	notch	ADJ
gs-3446	544	13	signaling	signal	VERB
gs-3446	544	14	maintains	maintain	VERB
gs-3446	544	15	quiescence	quiescence	NOUN
gs-3446	544	16	and	and	CCONJ
gs-3446	544	17	prevents	prevent	VERB
gs-3446	544	18	premature	premature	ADJ
gs-3446	544	19	differentiation	differentiation	NOUN
gs-3446	544	20	.	.	PUNCT
gs-3446	545	1	in	in	ADP
gs-3446	545	2	neural	neural	ADJ
gs-3446	545	3	stem	stem	NOUN
gs-3446	545	4	cells	cell	NOUN
gs-3446	545	5	,	,	PUNCT
gs-3446	545	6	notch	notch	NOUN
gs-3446	545	7	promotes	promote	VERB
gs-3446	545	8	self	self	NOUN
gs-3446	545	9	-	-	PUNCT
gs-3446	545	10	renewal	renewal	NOUN
gs-3446	545	11	and	and	CCONJ
gs-3446	545	12	inhibits	inhibit	VERB
gs-3446	545	13	neuronal	neuronal	ADJ
gs-3446	545	14	differentiation	differentiation	NOUN
gs-3446	545	15	.	.	PUNCT
gs-3446	546	1	3	3	X
gs-3446	546	2	.	.	X
gs-3446	546	3	hedgehog	hedgehog	PROPN
gs-3446	546	4	(	(	PUNCT
gs-3446	546	5	hh	hh	PROPN
gs-3446	546	6	)	)	PUNCT
gs-3446	546	7	signaling	signal	VERB
gs-3446	546	8	:	:	PUNCT
gs-3446	546	9	○	○	ADJ
gs-3446	546	10	role	role	NOUN
gs-3446	546	11	:	:	PUNCT
gs-3446	546	12	the	the	DET
gs-3446	546	13	hedgehog	hedgehog	NOUN
gs-3446	546	14	pathway	pathway	NOUN
gs-3446	546	15	is	be	AUX
gs-3446	546	16	involved	involve	VERB
gs-3446	546	17	in	in	ADP
gs-3446	546	18	stem	stem	NOUN
gs-3446	546	19	cell	cell	NOUN
gs-3446	546	20	maintenance	maintenance	NOUN
gs-3446	546	21	,	,	PUNCT
gs-3446	546	22	proliferation	proliferation	NOUN
gs-3446	546	23	,	,	PUNCT
gs-3446	546	24	and	and	CCONJ
gs-3446	546	25	tissue	tissue	NOUN
gs-3446	546	26	patterning	patterning	NOUN
gs-3446	546	27	.	.	PUNCT
gs-3446	547	1	activation	activation	NOUN
gs-3446	547	2	of	of	ADP
gs-3446	547	3	hh	hh	PROPN
gs-3446	547	4	signaling	signal	VERB
gs-3446	547	5	leads	lead	NOUN
gs-3446	547	6	to	to	ADP
gs-3446	547	7	the	the	DET
gs-3446	547	8	stabilization	stabilization	NOUN
gs-3446	547	9	and	and	CCONJ
gs-3446	547	10	nuclear	nuclear	ADJ
gs-3446	547	11	translocation	translocation	NOUN
gs-3446	547	12	of	of	ADP
gs-3446	547	13	gli	gli	NOUN
gs-3446	547	14	transcription	transcription	NOUN
gs-3446	547	15	factors	factor	NOUN
gs-3446	547	16	,	,	PUNCT
gs-3446	547	17	which	which	PRON
gs-3446	547	18	regulate	regulate	VERB
gs-3446	547	19	target	target	NOUN
gs-3446	547	20	genes	gene	NOUN
gs-3446	547	21	involved	involve	VERB
gs-3446	547	22	in	in	ADP
gs-3446	547	23	cell	cell	NOUN
gs-3446	547	24	cycle	cycle	NOUN
gs-3446	547	25	control	control	NOUN
gs-3446	547	26	and	and	CCONJ
gs-3446	547	27	stem	stem	NOUN
gs-3446	547	28	cell	cell	NOUN
gs-3446	547	29	identity	identity	NOUN
gs-3446	547	30	.	.	PUNCT
gs-3446	548	1	○	○	ADJ
gs-3446	548	2	examples	example	NOUN
gs-3446	548	3	:	:	PUNCT
gs-3446	548	4	in	in	ADP
gs-3446	548	5	skin	skin	NOUN
gs-3446	548	6	stem	stem	NOUN
gs-3446	548	7	cells	cell	NOUN
gs-3446	548	8	,	,	PUNCT
gs-3446	548	9	hh	hh	PROPN
gs-3446	548	10	signaling	signal	VERB
gs-3446	548	11	regulates	regulate	VERB
gs-3446	548	12	hair	hair	NOUN
gs-3446	548	13	follicle	follicle	NOUN
gs-3446	548	14	regeneration	regeneration	NOUN
gs-3446	548	15	.	.	PUNCT
gs-3446	549	1	in	in	ADP
gs-3446	549	2	cancer	cancer	NOUN
gs-3446	549	3	,	,	PUNCT
gs-3446	549	4	aberrant	aberrant	ADJ
gs-3446	549	5	hh	hh	ADJ
gs-3446	549	6	signaling	signal	VERB
gs-3446	549	7	is	be	AUX
gs-3446	549	8	associated	associate	VERB
gs-3446	549	9	with	with	ADP
gs-3446	549	10	the	the	DET
gs-3446	549	11	maintenance	maintenance	NOUN
gs-3446	549	12	of	of	ADP
gs-3446	549	13	cancer	cancer	NOUN
gs-3446	549	14	stem	stem	NOUN
gs-3446	549	15	cells	cell	NOUN
gs-3446	549	16	.	.	PUNCT
gs-3446	550	1	4	4	X
gs-3446	550	2	.	.	X
gs-3446	550	3	tgf	tgf	PROPN
gs-3446	550	4	-	-	PUNCT
gs-3446	550	5	β	β	NOUN
gs-3446	550	6	/	/	SYM
gs-3446	550	7	bmp	bmp	NOUN
gs-3446	550	8	signaling	signal	VERB
gs-3446	550	9	:	:	PUNCT
gs-3446	550	10	○	○	ADJ
gs-3446	550	11	role	role	NOUN
gs-3446	550	12	:	:	PUNCT
gs-3446	550	13	the	the	DET
gs-3446	550	14	tgf	tgf	PROPN
gs-3446	550	15	-	-	PUNCT
gs-3446	550	16	β	β	PROPN
gs-3446	550	17	(	(	PUNCT
gs-3446	550	18	transforming	transform	VERB
gs-3446	550	19	growth	growth	NOUN
gs-3446	550	20	factor	factor	NOUN
gs-3446	550	21	-	-	PUNCT
gs-3446	550	22	beta	beta	NOUN
gs-3446	550	23	)	)	PUNCT
gs-3446	550	24	and	and	CCONJ
gs-3446	550	25	bmp	bmp	NOUN
gs-3446	550	26	(	(	PUNCT
gs-3446	550	27	bone	bone	NOUN
gs-3446	550	28	morphogenetic	morphogenetic	ADJ
gs-3446	550	29	protein	protein	NOUN
gs-3446	550	30	)	)	PUNCT
gs-3446	550	31	pathways	pathway	NOUN
gs-3446	550	32	regulate	regulate	VERB
gs-3446	550	33	stem	stem	NOUN
gs-3446	550	34	cell	cell	NOUN
gs-3446	550	35	differentiation	differentiation	NOUN
gs-3446	550	36	and	and	CCONJ
gs-3446	550	37	proliferation	proliferation	NOUN
gs-3446	550	38	.	.	PUNCT
gs-3446	551	1	tgf	tgf	PROPN
gs-3446	551	2	-	-	PUNCT
gs-3446	551	3	β	β	PROPN
gs-3446	551	4	signaling	signal	VERB
gs-3446	551	5	often	often	ADV
gs-3446	551	6	promotes	promote	VERB
gs-3446	551	7	differentiation	differentiation	NOUN
gs-3446	551	8	,	,	PUNCT
gs-3446	551	9	while	while	SCONJ
gs-3446	551	10	bmp	bmp	ADJ
gs-3446	551	11	signaling	signaling	NOUN
gs-3446	551	12	can	can	AUX
gs-3446	551	13	either	either	CCONJ
gs-3446	551	14	promote	promote	VERB
gs-3446	551	15	or	or	CCONJ
gs-3446	551	16	inhibit	inhibit	VERB
gs-3446	551	17	stem	stem	NOUN
gs-3446	551	18	cell	cell	NOUN
gs-3446	551	19	self	self	NOUN
gs-3446	551	20	-	-	PUNCT
gs-3446	551	21	renewal	renewal	NOUN
gs-3446	551	22	depending	depend	VERB
gs-3446	551	23	on	on	ADP
gs-3446	551	24	the	the	DET
gs-3446	551	25	context	context	NOUN
gs-3446	551	26	[	[	X
gs-3446	551	27	88	88	NUM
gs-3446	551	28	]	]	PUNCT
gs-3446	551	29	.	.	PUNCT
gs-3446	552	1	○	○	ADJ
gs-3446	552	2	examples	example	NOUN
gs-3446	552	3	:	:	PUNCT
gs-3446	552	4	in	in	ADP
gs-3446	552	5	mesenchymal	mesenchymal	ADJ
gs-3446	552	6	stem	stem	NOUN
gs-3446	552	7	cells	cell	NOUN
gs-3446	552	8	(	(	PUNCT
gs-3446	552	9	mscs	msc	NOUN
gs-3446	552	10	)	)	PUNCT
gs-3446	552	11	,	,	PUNCT
gs-3446	552	12	bmp	bmp	NOUN
gs-3446	552	13	signaling	signal	VERB
gs-3446	552	14	induces	induce	VERB
gs-3446	552	15	osteogenic	osteogenic	ADJ
gs-3446	552	16	differentiation	differentiation	NOUN
gs-3446	552	17	,	,	PUNCT
gs-3446	552	18	while	while	SCONJ
gs-3446	552	19	tgf	tgf	PROPN
gs-3446	552	20	-	-	PUNCT
gs-3446	552	21	β	β	NOUN
gs-3446	552	22	signaling	signal	VERB
gs-3446	552	23	promotes	promote	NOUN
gs-3446	552	24	chondrogenesis	chondrogenesis	NOUN
gs-3446	552	25	.	.	PUNCT
gs-3446	553	1	5	5	X
gs-3446	553	2	.	.	X
gs-3446	553	3	pi3k	pi3k	NOUN
gs-3446	553	4	/	/	SYM
gs-3446	553	5	akt	akt	PROPN
gs-3446	553	6	/	/	SYM
gs-3446	553	7	mtor	mtor	PROPN
gs-3446	553	8	pathway	pathway	NOUN
gs-3446	553	9	:	:	PUNCT
gs-3446	553	10	○	○	ADJ
gs-3446	553	11	role	role	NOUN
gs-3446	553	12	:	:	PUNCT
gs-3446	553	13	the	the	DET
gs-3446	553	14	pi3k	pi3k	PROPN
gs-3446	553	15	/	/	SYM
gs-3446	553	16	akt	akt	PROPN
gs-3446	553	17	/	/	SYM
gs-3446	553	18	mtor	mtor	PROPN
gs-3446	553	19	pathway	pathway	NOUN
gs-3446	553	20	is	be	AUX
gs-3446	553	21	a	a	DET
gs-3446	553	22	central	central	ADJ
gs-3446	553	23	regulator	regulator	NOUN
gs-3446	553	24	of	of	ADP
gs-3446	553	25	cell	cell	NOUN
gs-3446	553	26	growth	growth	NOUN
gs-3446	553	27	,	,	PUNCT
gs-3446	553	28	proliferation	proliferation	NOUN
gs-3446	553	29	,	,	PUNCT
gs-3446	553	30	and	and	CCONJ
gs-3446	553	31	survival	survival	NOUN
gs-3446	553	32	.	.	PUNCT
gs-3446	554	1	activation	activation	NOUN
gs-3446	554	2	of	of	ADP
gs-3446	554	3	this	this	DET
gs-3446	554	4	pathway	pathway	NOUN
gs-3446	554	5	promotes	promote	VERB
gs-3446	554	6	stem	stem	NOUN
gs-3446	554	7	cell	cell	NOUN
gs-3446	554	8	self	self	NOUN
gs-3446	554	9	-	-	PUNCT
gs-3446	554	10	renewal	renewal	NOUN
gs-3446	554	11	and	and	CCONJ
gs-3446	554	12	inhibits	inhibit	VERB
gs-3446	554	13	differentiation	differentiation	NOUN
gs-3446	554	14	.	.	PUNCT
gs-3446	555	1	○	○	ADJ
gs-3446	555	2	examples	example	NOUN
gs-3446	555	3	:	:	PUNCT
gs-3446	555	4	in	in	ADP
gs-3446	555	5	embryonic	embryonic	ADJ
gs-3446	555	6	stem	stem	NOUN
gs-3446	555	7	cells	cell	NOUN
gs-3446	555	8	(	(	PUNCT
gs-3446	555	9	escs	esc	NOUN
gs-3446	555	10	)	)	PUNCT
gs-3446	555	11	,	,	PUNCT
gs-3446	555	12	pi3k	pi3k	PROPN
gs-3446	555	13	/	/	SYM
gs-3446	555	14	akt	akt	PROPN
gs-3446	555	15	signaling	signal	VERB
gs-3446	555	16	maintains	maintain	VERB
gs-3446	555	17	pluripotency	pluripotency	NOUN
gs-3446	555	18	by	by	ADP
gs-3446	555	19	stabilizing	stabilize	VERB
gs-3446	555	20	oct4	oct4	PROPN
gs-3446	555	21	and	and	CCONJ
gs-3446	555	22	nanog	nanog	PROPN
gs-3446	555	23	expression	expression	NOUN
gs-3446	555	24	.	.	PUNCT
gs-3446	556	1	in	in	ADP
gs-3446	556	2	cancer	cancer	NOUN
gs-3446	556	3	stem	stem	NOUN
gs-3446	556	4	cells	cell	NOUN
gs-3446	556	5	,	,	PUNCT
gs-3446	556	6	this	this	DET
gs-3446	556	7	pathway	pathway	NOUN
gs-3446	556	8	is	be	AUX
gs-3446	556	9	often	often	ADV
gs-3446	556	10	hyperactivated	hyperactivate	VERB
gs-3446	556	11	,	,	PUNCT
gs-3446	556	12	contributing	contribute	VERB
gs-3446	556	13	to	to	ADP
gs-3446	556	14	tumor	tumor	NOUN
gs-3446	556	15	growth	growth	NOUN
gs-3446	556	16	and	and	CCONJ
gs-3446	556	17	therapy	therapy	NOUN
gs-3446	556	18	resistance	resistance	NOUN
gs-3446	556	19	.	.	PUNCT
gs-3446	557	1	6	6	NUM
gs-3446	557	2	.	.	X
gs-3446	557	3	jak	jak	PROPN
gs-3446	557	4	/	/	SYM
gs-3446	557	5	stat	stat	PROPN
gs-3446	557	6	signaling	signal	VERB
gs-3446	557	7	:	:	PUNCT
gs-3446	557	8	○	○	ADJ
gs-3446	557	9	role	role	NOUN
gs-3446	557	10	:	:	PUNCT
gs-3446	557	11	the	the	DET
gs-3446	557	12	jak	jak	PROPN
gs-3446	557	13	/	/	SYM
gs-3446	557	14	stat	stat	PROPN
gs-3446	557	15	pathway	pathway	NOUN
gs-3446	557	16	is	be	AUX
gs-3446	557	17	activated	activate	VERB
gs-3446	557	18	by	by	ADP
gs-3446	557	19	cytokines	cytokine	NOUN
gs-3446	557	20	and	and	CCONJ
gs-3446	557	21	growth	growth	NOUN
gs-3446	557	22	factors	factor	NOUN
gs-3446	557	23	,	,	PUNCT
gs-3446	557	24	leading	lead	VERB
gs-3446	557	25	to	to	ADP
gs-3446	557	26	the	the	DET
gs-3446	557	27	phosphorylation	phosphorylation	NOUN
gs-3446	557	28	and	and	CCONJ
gs-3446	557	29	nuclear	nuclear	ADJ
gs-3446	557	30	translocation	translocation	NOUN
gs-3446	557	31	of	of	ADP
gs-3446	557	32	stat	stat	NOUN
gs-3446	557	33	proteins	protein	NOUN
gs-3446	557	34	,	,	PUNCT
gs-3446	557	35	which	which	PRON
gs-3446	557	36	regulate	regulate	VERB
gs-3446	557	37	gene	gene	NOUN
gs-3446	557	38	expression	expression	NOUN
gs-3446	557	39	involved	involve	VERB
gs-3446	557	40	in	in	ADP
gs-3446	557	41	cell	cell	NOUN
gs-3446	557	42	proliferation	proliferation	NOUN
gs-3446	557	43	and	and	CCONJ
gs-3446	557	44	survival	survival	NOUN
gs-3446	557	45	.	.	PUNCT
gs-3446	558	1	○	○	ADJ
gs-3446	558	2	examples	example	NOUN
gs-3446	558	3	:	:	PUNCT
gs-3446	558	4	in	in	ADP
gs-3446	558	5	hematopoietic	hematopoietic	ADJ
gs-3446	558	6	stem	stem	NOUN
gs-3446	558	7	cells	cell	NOUN
gs-3446	558	8	,	,	PUNCT
gs-3446	558	9	jak	jak	PROPN
gs-3446	558	10	/	/	SYM
gs-3446	558	11	stat	stat	PROPN
gs-3446	558	12	signaling	signal	VERB
gs-3446	558	13	is	be	AUX
gs-3446	558	14	critical	critical	ADJ
gs-3446	558	15	for	for	ADP
gs-3446	558	16	maintaining	maintain	VERB
gs-3446	558	17	stem	stem	NOUN
gs-3446	558	18	cell	cell	NOUN
gs-3446	558	19	self	self	NOUN
gs-3446	558	20	-	-	PUNCT
gs-3446	558	21	renewal	renewal	NOUN
gs-3446	558	22	and	and	CCONJ
gs-3446	558	23	responding	respond	VERB
gs-3446	558	24	to	to	ADP
gs-3446	558	25	inflammatory	inflammatory	ADJ
gs-3446	558	26	signals	signal	NOUN
gs-3446	558	27	.	.	PUNCT
gs-3446	559	1	georgian	georgian	ADJ
gs-3446	559	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	559	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	559	4	ტ.	ტ.	VERB
gs-3446	559	5	7	7	NUM
gs-3446	559	6	n	n	PRON
gs-3446	559	7	1	1	NUM
gs-3446	559	8	,	,	PUNCT
gs-3446	559	9	2025	2025	NUM
gs-3446	559	10	306	306	NUM
gs-3446	559	11	extrinsic	extrinsic	ADJ
gs-3446	559	12	signals	signal	NOUN
gs-3446	559	13	from	from	ADP
gs-3446	559	14	the	the	DET
gs-3446	559	15	stem	stem	NOUN
gs-3446	559	16	cell	cell	NOUN
gs-3446	559	17	niche	niche	NOUN
gs-3446	559	18	the	the	DET
gs-3446	559	19	stem	stem	NOUN
gs-3446	559	20	cell	cell	NOUN
gs-3446	559	21	niche	niche	NOUN
gs-3446	559	22	provides	provide	VERB
gs-3446	559	23	a	a	DET
gs-3446	559	24	specialized	specialized	ADJ
gs-3446	559	25	microenvironment	microenvironment	NOUN
gs-3446	559	26	that	that	PRON
gs-3446	559	27	regulates	regulate	VERB
gs-3446	559	28	stem	stem	NOUN
gs-3446	559	29	cell	cell	NOUN
gs-3446	559	30	behavior	behavior	NOUN
gs-3446	559	31	through	through	ADP
gs-3446	559	32	physical	physical	ADJ
gs-3446	559	33	and	and	CCONJ
gs-3446	559	34	biochemical	biochemical	ADJ
gs-3446	559	35	cues	cue	NOUN
gs-3446	559	36	.	.	PUNCT
gs-3446	560	1	key	key	ADJ
gs-3446	560	2	components	component	NOUN
gs-3446	560	3	of	of	ADP
gs-3446	560	4	the	the	DET
gs-3446	560	5	niche	niche	NOUN
gs-3446	560	6	include	include	VERB
gs-3446	560	7	:	:	PUNCT
gs-3446	560	8	1	1	X
gs-3446	560	9	.	.	X
gs-3446	560	10	extracellular	extracellular	ADJ
gs-3446	560	11	matrix	matrix	NOUN
gs-3446	560	12	(	(	PUNCT
gs-3446	560	13	ecm	ecm	PROPN
gs-3446	560	14	):	):	PUNCT
gs-3446	560	15	○	○	PROPN
gs-3446	560	16	the	the	DET
gs-3446	560	17	ecm	ecm	NOUN
gs-3446	560	18	provides	provide	VERB
gs-3446	560	19	structural	structural	ADJ
gs-3446	560	20	support	support	NOUN
gs-3446	560	21	and	and	CCONJ
gs-3446	560	22	biochemical	biochemical	ADJ
gs-3446	560	23	signals	signal	NOUN
gs-3446	560	24	that	that	PRON
gs-3446	560	25	influence	influence	NOUN
gs-3446	560	26	stem	stem	NOUN
gs-3446	560	27	cell	cell	NOUN
gs-3446	560	28	behavior	behavior	NOUN
gs-3446	560	29	.	.	PUNCT
gs-3446	561	1	integrins	integrin	NOUN
gs-3446	561	2	and	and	CCONJ
gs-3446	561	3	other	other	ADJ
gs-3446	561	4	cell	cell	NOUN
gs-3446	561	5	surface	surface	NOUN
gs-3446	561	6	receptors	receptor	NOUN
gs-3446	561	7	interact	interact	VERB
gs-3446	561	8	with	with	ADP
gs-3446	561	9	ecm	ecm	PROPN
gs-3446	561	10	components	component	NOUN
gs-3446	561	11	(	(	PUNCT
gs-3446	561	12	e.g.	e.g.	ADV
gs-3446	561	13	,	,	PUNCT
gs-3446	561	14	fibronectin	fibronectin	NOUN
gs-3446	561	15	,	,	PUNCT
gs-3446	561	16	laminin	laminin	NOUN
gs-3446	561	17	)	)	PUNCT
gs-3446	561	18	to	to	PART
gs-3446	561	19	regulate	regulate	VERB
gs-3446	561	20	cell	cell	NOUN
gs-3446	561	21	adhesion	adhesion	NOUN
gs-3446	561	22	,	,	PUNCT
gs-3446	561	23	migration	migration	NOUN
gs-3446	561	24	,	,	PUNCT
gs-3446	561	25	and	and	CCONJ
gs-3446	561	26	signaling	signal	VERB
gs-3446	561	27	.	.	PUNCT
gs-3446	562	1	2	2	X
gs-3446	562	2	.	.	X
gs-3446	562	3	cell	cell	NOUN
gs-3446	562	4	-	-	PUNCT
gs-3446	562	5	cell	cell	NOUN
gs-3446	562	6	interactions	interaction	NOUN
gs-3446	562	7	:	:	PUNCT
gs-3446	562	8	○	○	ADJ
gs-3446	562	9	direct	direct	ADJ
gs-3446	562	10	cell	cell	NOUN
gs-3446	562	11	-	-	PUNCT
gs-3446	562	12	cell	cell	NOUN
gs-3446	562	13	interactions	interaction	NOUN
gs-3446	562	14	,	,	PUNCT
gs-3446	562	15	such	such	ADJ
gs-3446	562	16	as	as	ADP
gs-3446	562	17	those	those	PRON
gs-3446	562	18	mediated	mediate	VERB
gs-3446	562	19	by	by	ADP
gs-3446	562	20	cadherins	cadherin	NOUN
gs-3446	562	21	and	and	CCONJ
gs-3446	562	22	gap	gap	NOUN
gs-3446	562	23	junctions	junction	NOUN
gs-3446	562	24	,	,	PUNCT
gs-3446	562	25	play	play	VERB
gs-3446	562	26	a	a	DET
gs-3446	562	27	role	role	NOUN
gs-3446	562	28	in	in	ADP
gs-3446	562	29	stem	stem	NOUN
gs-3446	562	30	cell	cell	NOUN
gs-3446	562	31	maintenance	maintenance	NOUN
gs-3446	562	32	and	and	CCONJ
gs-3446	562	33	differentiation	differentiation	NOUN
gs-3446	562	34	.	.	PUNCT
gs-3446	563	1	for	for	ADP
gs-3446	563	2	example	example	NOUN
gs-3446	563	3	,	,	PUNCT
gs-3446	563	4	e	e	NOUN
gs-3446	563	5	-	-	NOUN
gs-3446	563	6	cadherin	cadherin	NOUN
gs-3446	563	7	-	-	PUNCT
gs-3446	563	8	mediated	mediate	VERB
gs-3446	563	9	cell	cell	NOUN
gs-3446	563	10	adhesion	adhesion	NOUN
gs-3446	563	11	is	be	AUX
gs-3446	563	12	important	important	ADJ
gs-3446	563	13	for	for	ADP
gs-3446	563	14	maintaining	maintain	VERB
gs-3446	563	15	pluripotency	pluripotency	NOUN
gs-3446	563	16	in	in	ADP
gs-3446	563	17	escs	esc	NOUN
gs-3446	563	18	.	.	PUNCT
gs-3446	564	1	3	3	X
gs-3446	564	2	.	.	X
gs-3446	564	3	soluble	soluble	ADJ
gs-3446	564	4	factors	factor	NOUN
gs-3446	564	5	:	:	PUNCT
gs-3446	564	6	○	○	ADJ
gs-3446	564	7	growth	growth	NOUN
gs-3446	564	8	factors	factor	NOUN
gs-3446	564	9	,	,	PUNCT
gs-3446	564	10	cytokines	cytokine	NOUN
gs-3446	564	11	,	,	PUNCT
gs-3446	564	12	and	and	CCONJ
gs-3446	564	13	chemokines	chemokine	NOUN
gs-3446	564	14	secreted	secrete	VERB
gs-3446	564	15	by	by	ADP
gs-3446	564	16	niche	niche	NOUN
gs-3446	564	17	cells	cell	NOUN
gs-3446	564	18	or	or	CCONJ
gs-3446	564	19	present	present	ADJ
gs-3446	564	20	in	in	ADP
gs-3446	564	21	the	the	DET
gs-3446	564	22	extracellular	extracellular	ADJ
gs-3446	564	23	fluid	fluid	NOUN
gs-3446	564	24	regulate	regulate	NOUN
gs-3446	564	25	stem	stem	NOUN
gs-3446	564	26	cell	cell	NOUN
gs-3446	564	27	division	division	NOUN
gs-3446	564	28	.	.	PUNCT
gs-3446	565	1	examples	example	NOUN
gs-3446	565	2	include	include	VERB
gs-3446	565	3	scf	scf	PROPN
gs-3446	565	4	(	(	PUNCT
gs-3446	565	5	stem	stem	NOUN
gs-3446	565	6	cell	cell	NOUN
gs-3446	565	7	factor	factor	NOUN
gs-3446	565	8	)	)	PUNCT
gs-3446	565	9	,	,	PUNCT
gs-3446	565	10	cxcl12	cxcl12	ADJ
gs-3446	565	11	(	(	PUNCT
gs-3446	565	12	sdf-1	sdf-1	NUM
gs-3446	565	13	)	)	PUNCT
gs-3446	565	14	,	,	PUNCT
gs-3446	565	15	and	and	CCONJ
gs-3446	565	16	fgf	fgf	PROPN
gs-3446	565	17	(	(	PUNCT
gs-3446	565	18	fibroblast	fibroblast	ADJ
gs-3446	565	19	growth	growth	NOUN
gs-3446	565	20	factor	factor	NOUN
gs-3446	565	21	)	)	PUNCT
gs-3446	565	22	.	.	PUNCT
gs-3446	566	1	4	4	X
gs-3446	566	2	.	.	X
gs-3446	566	3	mechanical	mechanical	ADJ
gs-3446	566	4	forces	force	NOUN
gs-3446	566	5	:	:	PUNCT
gs-3446	566	6	○	○	ADJ
gs-3446	566	7	physical	physical	ADJ
gs-3446	566	8	forces	force	NOUN
gs-3446	566	9	,	,	PUNCT
gs-3446	566	10	such	such	ADJ
gs-3446	566	11	as	as	ADP
gs-3446	566	12	shear	shear	NOUN
gs-3446	566	13	stress	stress	NOUN
gs-3446	566	14	,	,	PUNCT
gs-3446	566	15	stiffness	stiffness	NOUN
gs-3446	566	16	,	,	PUNCT
gs-3446	566	17	and	and	CCONJ
gs-3446	566	18	tension	tension	NOUN
gs-3446	566	19	,	,	PUNCT
gs-3446	566	20	influence	influence	NOUN
gs-3446	566	21	stem	stem	NOUN
gs-3446	566	22	cell	cell	NOUN
gs-3446	566	23	behavior	behavior	NOUN
gs-3446	566	24	.	.	PUNCT
gs-3446	567	1	for	for	ADP
gs-3446	567	2	example	example	NOUN
gs-3446	567	3	,	,	PUNCT
gs-3446	567	4	mechanical	mechanical	ADJ
gs-3446	567	5	stiffness	stiffness	NOUN
gs-3446	567	6	of	of	ADP
gs-3446	567	7	the	the	DET
gs-3446	567	8	ecm	ecm	NOUN
gs-3446	567	9	can	can	AUX
gs-3446	567	10	direct	direct	VERB
gs-3446	567	11	mesenchymal	mesenchymal	NOUN
gs-3446	567	12	stem	stem	NOUN
gs-3446	567	13	cell	cell	NOUN
gs-3446	567	14	differentiation	differentiation	NOUN
gs-3446	567	15	toward	toward	ADP
gs-3446	567	16	osteogenic	osteogenic	ADJ
gs-3446	567	17	or	or	CCONJ
gs-3446	567	18	adipogenic	adipogenic	ADJ
gs-3446	567	19	lineages	lineage	NOUN
gs-3446	567	20	.	.	PUNCT
gs-3446	568	1	clinical	clinical	ADJ
gs-3446	568	2	implications	implication	NOUN
gs-3446	568	3	understanding	understand	VERB
gs-3446	568	4	the	the	DET
gs-3446	568	5	signals	signal	NOUN
gs-3446	568	6	that	that	PRON
gs-3446	568	7	regulate	regulate	VERB
gs-3446	568	8	stem	stem	NOUN
gs-3446	568	9	cell	cell	NOUN
gs-3446	568	10	division	division	NOUN
gs-3446	568	11	has	have	VERB
gs-3446	568	12	significant	significant	ADJ
gs-3446	568	13	implications	implication	NOUN
gs-3446	568	14	for	for	ADP
gs-3446	568	15	regenerative	regenerative	ADJ
gs-3446	568	16	medicine	medicine	NOUN
gs-3446	568	17	and	and	CCONJ
gs-3446	568	18	cancer	cancer	NOUN
gs-3446	568	19	therapy	therapy	NOUN
gs-3446	568	20	.	.	PUNCT
gs-3446	569	1	for	for	ADP
gs-3446	569	2	example	example	NOUN
gs-3446	569	3	:	:	PUNCT
gs-3446	569	4	●	●	PUNCT
gs-3446	569	5	regenerative	regenerative	ADJ
gs-3446	569	6	medicine	medicine	NOUN
gs-3446	569	7	:	:	PUNCT
gs-3446	569	8	manipulating	manipulate	VERB
gs-3446	569	9	signaling	signal	VERB
gs-3446	569	10	pathways	pathway	NOUN
gs-3446	569	11	(	(	PUNCT
gs-3446	569	12	e.g.	e.g.	ADV
gs-3446	569	13	,	,	PUNCT
gs-3446	569	14	wnt	wnt	NOUN
gs-3446	569	15	,	,	PUNCT
gs-3446	569	16	notch	notch	NOUN
gs-3446	569	17	)	)	PUNCT
gs-3446	569	18	can	can	AUX
gs-3446	569	19	enhance	enhance	VERB
gs-3446	569	20	stem	stem	NOUN
gs-3446	569	21	cell	cell	NOUN
gs-3446	569	22	proliferation	proliferation	NOUN
gs-3446	569	23	and	and	CCONJ
gs-3446	569	24	differentiation	differentiation	NOUN
gs-3446	569	25	for	for	ADP
gs-3446	569	26	tissue	tissue	NOUN
gs-3446	569	27	repair	repair	NOUN
gs-3446	569	28	and	and	CCONJ
gs-3446	569	29	organ	organ	NOUN
gs-3446	569	30	regeneration	regeneration	NOUN
gs-3446	569	31	[	[	X
gs-3446	569	32	98	98	NUM
gs-3446	569	33	]	]	SYM
gs-3446	569	34	.	.	PUNCT
gs-3446	570	1	●	●	PUNCT
gs-3446	570	2	cancer	cancer	NOUN
gs-3446	570	3	therapy	therapy	NOUN
gs-3446	570	4	:	:	PUNCT
gs-3446	570	5	targeting	target	VERB
gs-3446	570	6	signaling	signal	VERB
gs-3446	570	7	pathways	pathway	NOUN
gs-3446	570	8	that	that	PRON
gs-3446	570	9	maintain	maintain	VERB
gs-3446	570	10	cancer	cancer	NOUN
gs-3446	570	11	stem	stem	NOUN
gs-3446	570	12	cells	cell	NOUN
gs-3446	570	13	(	(	PUNCT
gs-3446	570	14	e.g.	e.g.	ADV
gs-3446	570	15	,	,	PUNCT
gs-3446	570	16	wnt	wnt	PROPN
gs-3446	570	17	,	,	PUNCT
gs-3446	570	18	hedgehog	hedgehog	NOUN
gs-3446	570	19	)	)	PUNCT
gs-3446	570	20	can	can	AUX
gs-3446	570	21	inhibit	inhibit	VERB
gs-3446	570	22	tumor	tumor	NOUN
gs-3446	570	23	growth	growth	NOUN
gs-3446	570	24	and	and	CCONJ
gs-3446	570	25	prevent	prevent	VERB
gs-3446	570	26	relapse	relapse	NOUN
gs-3446	570	27	.	.	PUNCT
gs-3446	571	1	in	in	ADP
gs-3446	571	2	conclusion	conclusion	NOUN
gs-3446	571	3	,	,	PUNCT
gs-3446	571	4	the	the	DET
gs-3446	571	5	regulation	regulation	NOUN
gs-3446	571	6	of	of	ADP
gs-3446	571	7	stem	stem	NOUN
gs-3446	571	8	cell	cell	NOUN
gs-3446	571	9	division	division	NOUN
gs-3446	571	10	is	be	AUX
gs-3446	571	11	a	a	DET
gs-3446	571	12	complex	complex	ADJ
gs-3446	571	13	process	process	NOUN
gs-3446	571	14	influenced	influence	VERB
gs-3446	571	15	by	by	ADP
gs-3446	571	16	multiple	multiple	ADJ
gs-3446	571	17	signaling	signal	VERB
gs-3446	571	18	pathways	pathway	NOUN
gs-3446	571	19	and	and	CCONJ
gs-3446	571	20	niche	niche	NOUN
gs-3446	571	21	factors	factor	NOUN
gs-3446	571	22	.	.	PUNCT
gs-3446	572	1	continued	continue	VERB
gs-3446	572	2	research	research	NOUN
gs-3446	572	3	into	into	ADP
gs-3446	572	4	these	these	DET
gs-3446	572	5	signals	signal	NOUN
gs-3446	572	6	will	will	AUX
gs-3446	572	7	provide	provide	VERB
gs-3446	572	8	new	new	ADJ
gs-3446	572	9	insights	insight	NOUN
gs-3446	572	10	into	into	ADP
gs-3446	572	11	stem	stem	NOUN
gs-3446	572	12	cell	cell	NOUN
gs-3446	572	13	biology	biology	NOUN
gs-3446	572	14	and	and	CCONJ
gs-3446	572	15	pave	pave	VERB
gs-3446	572	16	the	the	DET
gs-3446	572	17	way	way	NOUN
gs-3446	572	18	for	for	ADP
gs-3446	572	19	innovative	innovative	ADJ
gs-3446	572	20	therapeutic	therapeutic	ADJ
gs-3446	572	21	strategies	strategy	NOUN
gs-3446	572	22	.	.	PUNCT
gs-3446	573	1	orchestration	orchestration	NOUN
gs-3446	573	2	of	of	ADP
gs-3446	573	3	stem	stem	NOUN
gs-3446	573	4	cell	cell	NOUN
gs-3446	573	5	differentiation	differentiation	NOUN
gs-3446	573	6	a	a	DET
gs-3446	573	7	critical	critical	ADJ
gs-3446	573	8	factor	factor	NOUN
gs-3446	573	9	in	in	ADP
gs-3446	573	10	maintaining	maintain	VERB
gs-3446	573	11	equilibrium	equilibrium	NOUN
gs-3446	573	12	between	between	ADP
gs-3446	573	13	stem	stem	NOUN
gs-3446	573	14	cells	cell	NOUN
gs-3446	573	15	and	and	CCONJ
gs-3446	573	16	differentiated	differentiated	ADJ
gs-3446	573	17	cells	cell	NOUN
gs-3446	573	18	is	be	AUX
gs-3446	573	19	the	the	DET
gs-3446	573	20	precise	precise	ADJ
gs-3446	573	21	regulation	regulation	NOUN
gs-3446	573	22	of	of	ADP
gs-3446	573	23	stem	stem	NOUN
gs-3446	573	24	cell	cell	NOUN
gs-3446	573	25	progeny	progeny	NOUN
gs-3446	573	26	differentiation	differentiation	NOUN
gs-3446	573	27	.	.	PUNCT
gs-3446	574	1	the	the	DET
gs-3446	574	2	complexity	complexity	NOUN
gs-3446	574	3	of	of	ADP
gs-3446	574	4	this	this	DET
gs-3446	574	5	task	task	NOUN
gs-3446	574	6	increases	increase	VERB
gs-3446	574	7	with	with	ADP
gs-3446	574	8	the	the	DET
gs-3446	574	9	number	number	NOUN
gs-3446	574	10	of	of	ADP
gs-3446	574	11	available	available	ADJ
gs-3446	574	12	options	option	NOUN
gs-3446	574	13	.	.	PUNCT
gs-3446	575	1	vertebrate	vertebrate	ADJ
gs-3446	575	2	adult	adult	NOUN
gs-3446	575	3	stem	stem	NOUN
gs-3446	575	4	cells	cell	NOUN
gs-3446	575	5	are	be	AUX
gs-3446	575	6	tissue	tissue	NOUN
gs-3446	575	7	-	-	PUNCT
gs-3446	575	8	specific	specific	ADJ
gs-3446	575	9	,	,	PUNCT
gs-3446	575	10	limiting	limit	VERB
gs-3446	575	11	the	the	DET
gs-3446	575	12	potential	potential	ADJ
gs-3446	575	13	fates	fate	NOUN
gs-3446	575	14	of	of	ADP
gs-3446	575	15	georgian	georgian	ADJ
gs-3446	575	16	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3446	575	17	მეცნიერები	მეცნიერები	NOUN
gs-3446	575	18	ტ.	ტ.	VERB
gs-3446	575	19	7	7	NUM
gs-3446	575	20	n	n	PRON
gs-3446	575	21	1	1	NUM
gs-3446	575	22	,	,	PUNCT
gs-3446	575	23	2025	2025	NUM
gs-3446	575	24	307	307	NUM
gs-3446	575	25	progeny	progeny	NOUN
gs-3446	575	26	,	,	PUNCT
gs-3446	575	27	such	such	ADJ
gs-3446	575	28	as	as	ADP
gs-3446	575	29	goblet	goblet	NOUN
gs-3446	575	30	cells	cell	NOUN
gs-3446	575	31	,	,	PUNCT
gs-3446	575	32	paneth	paneth	ADJ
gs-3446	575	33	cells	cell	NOUN
gs-3446	575	34	,	,	PUNCT
gs-3446	575	35	enteroendocrine	enteroendocrine	ADJ
gs-3446	575	36	cells	cell	NOUN
gs-3446	575	37	,	,	PUNCT
gs-3446	575	38	and	and	CCONJ
gs-3446	575	39	absorptive	absorptive	ADJ
gs-3446	575	40	enterocytes	enterocyte	NOUN
gs-3446	575	41	in	in	ADP
gs-3446	575	42	the	the	DET
gs-3446	575	43	vertebrate	vertebrate	ADJ
gs-3446	575	44	intestine	intestine	NOUN
gs-3446	575	45	(	(	PUNCT
gs-3446	575	46	van	van	NOUN
gs-3446	575	47	der	der	NOUN
gs-3446	575	48	flier	flier	NOUN
gs-3446	575	49	and	and	CCONJ
gs-3446	575	50	clevers	clever	NOUN
gs-3446	575	51	2009	2009	NUM
gs-3446	575	52	)	)	PUNCT
gs-3446	575	53	.	.	PUNCT
gs-3446	576	1	signaling	signal	VERB
gs-3446	576	2	molecules	molecule	NOUN
gs-3446	576	3	play	play	VERB
gs-3446	576	4	a	a	DET
gs-3446	576	5	pivotal	pivotal	ADJ
gs-3446	576	6	role	role	NOUN
gs-3446	576	7	in	in	ADP
gs-3446	576	8	directed	direct	VERB
gs-3446	576	9	stem	stem	NOUN
gs-3446	576	10	cell	cell	NOUN
gs-3446	576	11	differentiation	differentiation	NOUN
gs-3446	576	12	.	.	PUNCT
gs-3446	577	1	major	major	ADJ
gs-3446	577	2	signaling	signal	VERB
gs-3446	577	3	pathways	pathway	NOUN
gs-3446	577	4	include	include	VERB
gs-3446	577	5	:	:	PUNCT
gs-3446	577	6	●	●	PUNCT
gs-3446	577	7	wnt	wnt	NOUN
gs-3446	577	8	/	/	SYM
gs-3446	577	9	β	β	NOUN
gs-3446	577	10	-	-	NOUN
gs-3446	577	11	catenin	catenin	NOUN
gs-3446	577	12	:	:	PUNCT
gs-3446	577	13	activates	activate	VERB
gs-3446	577	14	gene	gene	NOUN
gs-3446	577	15	expression	expression	NOUN
gs-3446	577	16	that	that	PRON
gs-3446	577	17	promotes	promote	VERB
gs-3446	577	18	differentiation	differentiation	NOUN
gs-3446	577	19	.	.	PUNCT
gs-3446	578	1	●	●	PUNCT
gs-3446	578	2	tgf	tgf	PROPN
gs-3446	578	3	-	-	PUNCT
gs-3446	578	4	β	β	PROPN
gs-3446	578	5	(	(	PUNCT
gs-3446	578	6	transforming	transform	VERB
gs-3446	578	7	growth	growth	NOUN
gs-3446	578	8	factor	factor	NOUN
gs-3446	578	9	beta	beta	NOUN
gs-3446	578	10	):	):	PUNCT
gs-3446	578	11	regulates	regulate	VERB
gs-3446	578	12	cell	cell	NOUN
gs-3446	578	13	proliferation	proliferation	NOUN
gs-3446	578	14	and	and	CCONJ
gs-3446	578	15	differentiation	differentiation	NOUN
gs-3446	578	16	.	.	PUNCT
gs-3446	579	1	●	●	PUNCT
gs-3446	579	2	fgf	fgf	NOUN
gs-3446	579	3	(	(	PUNCT
gs-3446	579	4	fibroblast	fibroblast	ADJ
gs-3446	579	5	growth	growth	NOUN
gs-3446	579	6	factor	factor	NOUN
gs-3446	579	7	):	):	PUNCT
gs-3446	579	8	maintains	maintain	VERB
gs-3446	579	9	pluripotency	pluripotency	NOUN
gs-3446	579	10	and	and	CCONJ
gs-3446	579	11	induces	induce	VERB
gs-3446	579	12	differentiation	differentiation	NOUN
gs-3446	579	13	.	.	PUNCT
gs-3446	580	1	the	the	DET
gs-3446	580	2	microenvironment	microenvironment	NOUN
gs-3446	580	3	(	(	PUNCT
gs-3446	580	4	niche	niche	NOUN
gs-3446	580	5	)	)	PUNCT
gs-3446	580	6	surrounding	surround	VERB
gs-3446	580	7	stem	stem	NOUN
gs-3446	580	8	cells	cell	NOUN
gs-3446	580	9	is	be	AUX
gs-3446	580	10	a	a	DET
gs-3446	580	11	critical	critical	ADJ
gs-3446	580	12	determinant	determinant	ADJ
gs-3446	580	13	influencing	influence	VERB
gs-3446	580	14	their	their	PRON
gs-3446	580	15	behavior	behavior	NOUN
gs-3446	580	16	.	.	PUNCT
gs-3446	581	1	interactions	interaction	NOUN
gs-3446	581	2	with	with	ADP
gs-3446	581	3	neighboring	neighboring	NOUN
gs-3446	581	4	cells	cell	NOUN
gs-3446	581	5	,	,	PUNCT
gs-3446	581	6	the	the	DET
gs-3446	581	7	extracellular	extracellular	ADJ
gs-3446	581	8	matrix	matrix	NOUN
gs-3446	581	9	,	,	PUNCT
gs-3446	581	10	and	and	CCONJ
gs-3446	581	11	signaling	signal	VERB
gs-3446	581	12	gradients	gradient	NOUN
gs-3446	581	13	shape	shape	VERB
gs-3446	581	14	the	the	DET
gs-3446	581	15	"	"	PUNCT
gs-3446	581	16	signaling	signal	VERB
gs-3446	581	17	landscape	landscape	NOUN
gs-3446	581	18	"	"	PUNCT
gs-3446	581	19	that	that	PRON
gs-3446	581	20	governs	govern	VERB
gs-3446	581	21	differentiation	differentiation	NOUN
gs-3446	581	22	.	.	PUNCT
gs-3446	582	1	examples	example	NOUN
gs-3446	582	2	include	include	VERB
gs-3446	582	3	:	:	PUNCT
gs-3446	582	4	●	●	NUM
gs-3446	582	5	extracellular	extracellular	ADJ
gs-3446	582	6	matrix	matrix	NOUN
gs-3446	582	7	:	:	PUNCT
gs-3446	582	8	physical	physical	ADJ
gs-3446	582	9	and	and	CCONJ
gs-3446	582	10	chemical	chemical	NOUN
gs-3446	582	11	properties	property	NOUN
gs-3446	582	12	guide	guide	VERB
gs-3446	582	13	differentiation	differentiation	NOUN
gs-3446	582	14	.	.	PUNCT
gs-3446	583	1	●	●	PUNCT
gs-3446	583	2	cellular	cellular	ADJ
gs-3446	583	3	interactions	interaction	NOUN
gs-3446	583	4	:	:	PUNCT
gs-3446	583	5	direct	direct	ADJ
gs-3446	583	6	cell	cell	NOUN
gs-3446	583	7	contacts	contact	NOUN
gs-3446	583	8	and	and	CCONJ
gs-3446	583	9	secretion	secretion	NOUN
gs-3446	583	10	of	of	ADP
gs-3446	583	11	growth	growth	NOUN
gs-3446	583	12	factors	factor	NOUN
gs-3446	583	13	activate	activate	VERB
gs-3446	583	14	or	or	CCONJ
gs-3446	583	15	inhibit	inhibit	VERB
gs-3446	583	16	differentiation	differentiation	NOUN
gs-3446	583	17	pathways	pathway	NOUN
gs-3446	583	18	.	.	PUNCT
gs-3446	584	1	stem	stem	NOUN
gs-3446	584	2	cell	cell	NOUN
gs-3446	584	3	differentiation	differentiation	NOUN
gs-3446	584	4	is	be	AUX
gs-3446	584	5	also	also	ADV
gs-3446	584	6	regulated	regulate	VERB
gs-3446	584	7	by	by	ADP
gs-3446	584	8	genetic	genetic	ADJ
gs-3446	584	9	and	and	CCONJ
gs-3446	584	10	epigenetic	epigenetic	ADJ
gs-3446	584	11	mechanisms	mechanism	NOUN
gs-3446	584	12	:	:	PUNCT
gs-3446	584	13	●	●	PUNCT
gs-3446	584	14	histone	histone	NOUN
gs-3446	584	15	modifications	modification	NOUN
gs-3446	584	16	:	:	PUNCT
gs-3446	584	17	chromatin	chromatin	NOUN
gs-3446	584	18	remodeling	remodeling	NOUN
gs-3446	584	19	influences	influence	NOUN
gs-3446	584	20	gene	gene	NOUN
gs-3446	584	21	accessibility	accessibility	NOUN
gs-3446	584	22	for	for	ADP
gs-3446	584	23	transcription	transcription	NOUN
gs-3446	584	24	.	.	PUNCT
gs-3446	585	1	●	●	PUNCT
gs-3446	585	2	dna	dna	NOUN
gs-3446	585	3	tension	tension	NOUN
gs-3446	585	4	alterations	alteration	NOUN
gs-3446	585	5	:	:	PUNCT
gs-3446	585	6	regulate	regulate	VERB
gs-3446	585	7	transcription	transcription	NOUN
gs-3446	585	8	factor	factor	NOUN
gs-3446	585	9	activity	activity	NOUN
gs-3446	585	10	and	and	CCONJ
gs-3446	585	11	cell	cell	NOUN
gs-3446	585	12	-	-	PUNCT
gs-3446	585	13	type	type	NOUN
gs-3446	585	14	-	-	PUNCT
gs-3446	585	15	specific	specific	ADJ
gs-3446	585	16	gene	gene	NOUN
gs-3446	585	17	expression	expression	NOUN
gs-3446	585	18	.	.	PUNCT
gs-3446	586	1	research	research	NOUN
gs-3446	586	2	demonstrates	demonstrate	VERB
gs-3446	586	3	how	how	SCONJ
gs-3446	586	4	various	various	ADJ
gs-3446	586	5	factors	factor	NOUN
gs-3446	586	6	direct	direct	ADJ
gs-3446	586	7	stem	stem	NOUN
gs-3446	586	8	cell	cell	NOUN
gs-3446	586	9	differentiation	differentiation	NOUN
gs-3446	586	10	in	in	ADP
gs-3446	586	11	clinical	clinical	ADJ
gs-3446	586	12	contexts	contexts	NOUN
gs-3446	586	13	.	.	PUNCT
gs-3446	587	1	for	for	ADP
gs-3446	587	2	instance	instance	NOUN
gs-3446	587	3	,	,	PUNCT
gs-3446	587	4	fgf	fgf	NOUN
gs-3446	587	5	-	-	PUNCT
gs-3446	587	6	induced	induce	VERB
gs-3446	587	7	neurogenic	neurogenic	ADJ
gs-3446	587	8	differentiation	differentiation	NOUN
gs-3446	587	9	of	of	ADP
gs-3446	587	10	induced	induced	ADJ
gs-3446	587	11	pluripotent	pluripotent	ADJ
gs-3446	587	12	stem	stem	NOUN
gs-3446	587	13	cells	cell	NOUN
gs-3446	587	14	(	(	PUNCT
gs-3446	587	15	ipscs	ipsc	NOUN
gs-3446	587	16	)	)	PUNCT
gs-3446	587	17	showcases	showcase	VERB
gs-3446	587	18	the	the	DET
gs-3446	587	19	potential	potential	NOUN
gs-3446	587	20	of	of	ADP
gs-3446	587	21	cellular	cellular	ADJ
gs-3446	587	22	therapies	therapy	NOUN
gs-3446	587	23	for	for	ADP
gs-3446	587	24	treating	treat	VERB
gs-3446	587	25	neurodegenerative	neurodegenerative	ADJ
gs-3446	587	26	disorders	disorder	NOUN
gs-3446	587	27	.	.	PUNCT
gs-3446	588	1	the	the	DET
gs-3446	588	2	orchestration	orchestration	NOUN
gs-3446	588	3	of	of	ADP
gs-3446	588	4	stem	stem	NOUN
gs-3446	588	5	cell	cell	NOUN
gs-3446	588	6	differentiation	differentiation	NOUN
gs-3446	588	7	is	be	AUX
gs-3446	588	8	a	a	DET
gs-3446	588	9	complex	complex	ADJ
gs-3446	588	10	process	process	NOUN
gs-3446	588	11	influenced	influence	VERB
gs-3446	588	12	by	by	ADP
gs-3446	588	13	multiple	multiple	ADJ
gs-3446	588	14	factors	factor	NOUN
gs-3446	588	15	,	,	PUNCT
gs-3446	588	16	including	include	VERB
gs-3446	588	17	signaling	signal	VERB
gs-3446	588	18	molecules	molecule	NOUN
gs-3446	588	19	,	,	PUNCT
gs-3446	588	20	microenvironmental	microenvironmental	ADJ
gs-3446	588	21	cues	cue	NOUN
gs-3446	588	22	,	,	PUNCT
gs-3446	588	23	and	and	CCONJ
gs-3446	588	24	genetic	genetic	ADJ
gs-3446	588	25	regulation	regulation	NOUN
gs-3446	588	26	.	.	PUNCT
gs-3446	589	1	understanding	understand	VERB
gs-3446	589	2	these	these	DET
gs-3446	589	3	mechanisms	mechanism	NOUN
gs-3446	589	4	opens	open	VERB
gs-3446	589	5	new	new	ADJ
gs-3446	589	6	avenues	avenue	NOUN
gs-3446	589	7	for	for	ADP
gs-3446	589	8	therapeutic	therapeutic	ADJ
gs-3446	589	9	strategies	strategy	NOUN
gs-3446	589	10	in	in	ADP
gs-3446	589	11	regenerative	regenerative	ADJ
gs-3446	589	12	medicine	medicine	NOUN
gs-3446	589	13	and	and	CCONJ
gs-3446	589	14	cell	cell	NOUN
gs-3446	589	15	therapy	therapy	NOUN
gs-3446	589	16	(	(	PUNCT
gs-3446	589	17	singh	singh	PROPN
gs-3446	589	18	et	et	PROPN
gs-3446	589	19	al	al	PROPN
gs-3446	589	20	.	.	PROPN
gs-3446	589	21	2015	2015	NUM
gs-3446	589	22	)	)	PUNCT
gs-3446	589	23	.	.	PUNCT
gs-3446	590	1	conceptual	conceptual	ADJ
gs-3446	590	2	problems	problem	NOUN
gs-3446	590	3	of	of	ADP
gs-3446	590	4	lineage	lineage	NOUN
gs-3446	590	5	organization	organization	NOUN
gs-3446	590	6	mechanisms	mechanism	NOUN
gs-3446	590	7	and	and	CCONJ
gs-3446	590	8	conceptual	conceptual	ADJ
gs-3446	590	9	principles	principle	NOUN
gs-3446	590	10	regulating	regulate	VERB
gs-3446	590	11	progenitor	progenitor	NOUN
gs-3446	590	12	cell	cell	NOUN
gs-3446	590	13	differentiation	differentiation	NOUN
gs-3446	590	14	remain	remain	VERB
gs-3446	590	15	speculative	speculative	ADJ
gs-3446	590	16	.	.	PUNCT
gs-3446	591	1	are	be	AUX
gs-3446	591	2	lineage	lineage	NOUN
gs-3446	591	3	choices	choice	NOUN
gs-3446	591	4	governed	govern	VERB
gs-3446	591	5	by	by	ADP
gs-3446	591	6	external	external	ADJ
gs-3446	591	7	signals	signal	NOUN
gs-3446	591	8	that	that	PRON
gs-3446	591	9	enable	enable	VERB
gs-3446	591	10	progenitors	progenitor	NOUN
gs-3446	591	11	to	to	PART
gs-3446	591	12	differentiate	differentiate	VERB
gs-3446	591	13	"	"	PUNCT
gs-3446	591	14	on	on	ADP
gs-3446	591	15	demand	demand	NOUN
gs-3446	591	16	"	"	PUNCT
gs-3446	591	17	?	?	PUNCT
gs-3446	591	18	or	or	CCONJ
gs-3446	591	19	do	do	VERB
gs-3446	591	20	internal	internal	ADJ
gs-3446	591	21	processes	process	NOUN
gs-3446	591	22	,	,	PUNCT
gs-3446	591	23	such	such	ADJ
gs-3446	591	24	as	as	ADP
gs-3446	591	25	the	the	DET
gs-3446	591	26	centriole	centriole	NOUN
gs-3446	591	27	-	-	PUNCT
gs-3446	591	28	based	base	VERB
gs-3446	591	29	differentiation	differentiation	NOUN
gs-3446	591	30	hypothesis	hypothesis	NOUN
gs-3446	591	31	(	(	PUNCT
gs-3446	591	32	tkemaladze	tkemaladze	NOUN
gs-3446	591	33	and	and	CCONJ
gs-3446	591	34	chichinadze	chichinadze	NOUN
gs-3446	591	35	2005	2005	NUM
gs-3446	591	36	)	)	PUNCT
gs-3446	591	37	,	,	PUNCT
gs-3446	591	38	drive	drive	VERB
gs-3446	591	39	lineage	lineage	NOUN
gs-3446	591	40	specification	specification	NOUN
gs-3446	591	41	?	?	PUNCT
gs-3446	592	1	"	"	PUNCT
gs-3446	592	2	on	on	ADP
gs-3446	592	3	-	-	PUNCT
gs-3446	592	4	demand	demand	NOUN
gs-3446	592	5	"	"	PUNCT
gs-3446	592	6	models	model	NOUN
gs-3446	592	7	imply	imply	VERB
gs-3446	592	8	flexibility	flexibility	NOUN
gs-3446	592	9	,	,	PUNCT
gs-3446	592	10	aligning	align	VERB
gs-3446	592	11	progenitor	progenitor	NOUN
gs-3446	592	12	differentiation	differentiation	NOUN
gs-3446	592	13	with	with	ADP
gs-3446	592	14	local	local	ADJ
gs-3446	592	15	requirements	requirement	NOUN
gs-3446	592	16	,	,	PUNCT
gs-3446	592	17	for	for	ADP
gs-3446	592	18	example	example	NOUN
gs-3446	592	19	,	,	PUNCT
gs-3446	592	20	replacing	replace	VERB
gs-3446	592	21	dying	die	VERB
gs-3446	592	22	cells	cell	NOUN
gs-3446	592	23	through	through	ADP
gs-3446	592	24	simultaneous	simultaneous	ADJ
gs-3446	592	25	differentiation	differentiation	NOUN
gs-3446	592	26	signals	signal	NOUN
gs-3446	592	27	.	.	PUNCT
gs-3446	593	1	however	however	ADV
gs-3446	593	2	,	,	PUNCT
gs-3446	593	3	such	such	ADJ
gs-3446	593	4	models	model	NOUN
gs-3446	593	5	require	require	VERB
gs-3446	593	6	numerous	numerous	ADJ
gs-3446	593	7	cell	cell	NOUN
gs-3446	593	8	-	-	PUNCT
gs-3446	593	9	specific	specific	NOUN
gs-3446	593	10	"	"	PUNCT
gs-3446	593	11	replace	replace	VERB
gs-3446	593	12	me	i	PRON
gs-3446	593	13	"	"	PUNCT
gs-3446	593	14	signals	signal	NOUN
gs-3446	593	15	and	and	CCONJ
gs-3446	593	16	may	may	AUX
gs-3446	593	17	fail	fail	VERB
gs-3446	593	18	when	when	SCONJ
gs-3446	593	19	entire	entire	ADJ
gs-3446	593	20	cell	cell	NOUN
gs-3446	593	21	types	type	NOUN
gs-3446	593	22	are	be	AUX
gs-3446	593	23	lost	lose	VERB
gs-3446	593	24	(	(	PUNCT
gs-3446	593	25	e.g.	e.g.	ADV
gs-3446	593	26	,	,	PUNCT
gs-3446	593	27	photoreceptors	photoreceptor	NOUN
gs-3446	593	28	in	in	ADP
gs-3446	593	29	planarian	planarian	ADJ
gs-3446	593	30	head	head	NOUN
gs-3446	593	31	amputation	amputation	NOUN
gs-3446	593	32	)	)	PUNCT
gs-3446	593	33	.	.	PUNCT
gs-3446	594	1	the	the	DET
gs-3446	594	2	ability	ability	NOUN
gs-3446	594	3	of	of	ADP
gs-3446	594	4	planarians	planarian	NOUN
gs-3446	594	5	to	to	PART
gs-3446	594	6	regenerate	regenerate	VERB
gs-3446	594	7	tissues	tissue	NOUN
gs-3446	594	8	and	and	CCONJ
gs-3446	594	9	georgian	georgian	ADJ
gs-3446	594	10	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3446	594	11	მეცნიერები	მეცნიერები	NOUN
gs-3446	594	12	ტ.	ტ.	VERB
gs-3446	594	13	7	7	NUM
gs-3446	594	14	n	n	PRON
gs-3446	594	15	1	1	NUM
gs-3446	594	16	,	,	PUNCT
gs-3446	594	17	2025	2025	NUM
gs-3446	594	18	308	308	NUM
gs-3446	594	19	organs	organ	NOUN
gs-3446	594	20	de	de	X
gs-3446	594	21	novo	novo	NOUN
gs-3446	594	22	challenges	challenge	VERB
gs-3446	594	23	any	any	DET
gs-3446	594	24	model	model	NOUN
gs-3446	594	25	requiring	require	VERB
gs-3446	594	26	pre	pre	ADJ
gs-3446	594	27	-	-	ADJ
gs-3446	594	28	existing	exist	VERB
gs-3446	594	29	differentiated	differentiated	ADJ
gs-3446	594	30	cells	cell	NOUN
gs-3446	594	31	for	for	ADP
gs-3446	594	32	progenitor	progenitor	NOUN
gs-3446	594	33	specification	specification	NOUN
gs-3446	594	34	(	(	PUNCT
gs-3446	594	35	iglesias	iglesias	PROPN
gs-3446	594	36	et	et	PROPN
gs-3446	594	37	al	al	PROPN
gs-3446	594	38	.	.	PROPN
gs-3446	594	39	2008	2008	NUM
gs-3446	594	40	)	)	PUNCT
gs-3446	594	41	.	.	PUNCT
gs-3446	595	1	conversely	conversely	ADV
gs-3446	595	2	,	,	PUNCT
gs-3446	595	3	progenitor	progenitor	NOUN
gs-3446	595	4	fate	fate	NOUN
gs-3446	595	5	decisions	decision	NOUN
gs-3446	595	6	through	through	ADP
gs-3446	595	7	intrinsic	intrinsic	ADJ
gs-3446	595	8	mechanisms	mechanism	NOUN
gs-3446	595	9	may	may	AUX
gs-3446	595	10	enable	enable	VERB
gs-3446	595	11	de	de	PROPN
gs-3446	595	12	novo	novo	NOUN
gs-3446	595	13	specification	specification	NOUN
gs-3446	595	14	of	of	ADP
gs-3446	595	15	lost	lost	ADJ
gs-3446	595	16	cell	cell	NOUN
gs-3446	595	17	types	type	NOUN
gs-3446	595	18	,	,	PUNCT
gs-3446	595	19	albeit	albeit	SCONJ
gs-3446	595	20	with	with	ADP
gs-3446	595	21	conceptual	conceptual	ADJ
gs-3446	595	22	trade	trade	NOUN
gs-3446	595	23	-	-	PUNCT
gs-3446	595	24	offs	off	NOUN
gs-3446	595	25	.	.	PUNCT
gs-3446	596	1	during	during	ADP
gs-3446	596	2	regeneration	regeneration	NOUN
gs-3446	596	3	,	,	PUNCT
gs-3446	596	4	specifying	specify	VERB
gs-3446	596	5	the	the	DET
gs-3446	596	6	exact	exact	ADJ
gs-3446	596	7	number	number	NOUN
gs-3446	596	8	and	and	CCONJ
gs-3446	596	9	types	type	NOUN
gs-3446	596	10	of	of	ADP
gs-3446	596	11	progenitors	progenitor	NOUN
gs-3446	596	12	far	far	ADV
gs-3446	596	13	in	in	ADP
gs-3446	596	14	advance	advance	NOUN
gs-3446	596	15	of	of	ADP
gs-3446	596	16	their	their	PRON
gs-3446	596	17	assembly	assembly	NOUN
gs-3446	596	18	into	into	ADP
gs-3446	596	19	tissues	tissue	NOUN
gs-3446	596	20	and	and	CCONJ
gs-3446	596	21	organs	organ	NOUN
gs-3446	596	22	(	(	PUNCT
gs-3446	596	23	lapan	lapan	NOUN
gs-3446	596	24	and	and	CCONJ
gs-3446	596	25	reddien	reddien	NOUN
gs-3446	596	26	2011	2011	NUM
gs-3446	596	27	)	)	PUNCT
gs-3446	596	28	is	be	AUX
gs-3446	596	29	difficult	difficult	ADJ
gs-3446	596	30	to	to	PART
gs-3446	596	31	reconcile	reconcile	VERB
gs-3446	596	32	with	with	ADP
gs-3446	596	33	stochastic	stochastic	ADJ
gs-3446	596	34	mechanisms	mechanism	NOUN
gs-3446	596	35	.	.	PUNCT
gs-3446	597	1	in	in	ADP
gs-3446	597	2	homeostasis	homeostasis	NOUN
gs-3446	597	3	,	,	PUNCT
gs-3446	597	4	relying	rely	VERB
gs-3446	597	5	solely	solely	ADV
gs-3446	597	6	on	on	ADP
gs-3446	597	7	intrinsic	intrinsic	ADJ
gs-3446	597	8	mechanisms	mechanism	NOUN
gs-3446	597	9	would	would	AUX
gs-3446	597	10	result	result	VERB
gs-3446	597	11	in	in	ADP
gs-3446	597	12	uniform	uniform	ADJ
gs-3446	597	13	progenitor	progenitor	NOUN
gs-3446	597	14	production	production	NOUN
gs-3446	597	15	throughout	throughout	ADP
gs-3446	597	16	the	the	DET
gs-3446	597	17	organism	organism	NOUN
gs-3446	597	18	,	,	PUNCT
gs-3446	597	19	leading	lead	VERB
gs-3446	597	20	to	to	ADP
gs-3446	597	21	inappropriate	inappropriate	ADJ
gs-3446	597	22	differentiation	differentiation	NOUN
gs-3446	597	23	(	(	PUNCT
gs-3446	597	24	e.g.	e.g.	ADV
gs-3446	597	25	,	,	PUNCT
gs-3446	597	26	photoreceptors	photoreceptor	NOUN
gs-3446	597	27	in	in	ADP
gs-3446	597	28	the	the	DET
gs-3446	597	29	tail	tail	NOUN
gs-3446	597	30	)	)	PUNCT
gs-3446	597	31	.	.	PUNCT
gs-3446	598	1	apoptosis	apoptosis	NOUN
gs-3446	598	2	or	or	CCONJ
gs-3446	598	3	long	long	ADJ
gs-3446	598	4	-	-	PUNCT
gs-3446	598	5	range	range	NOUN
gs-3446	598	6	migration	migration	NOUN
gs-3446	598	7	may	may	AUX
gs-3446	598	8	address	address	VERB
gs-3446	598	9	such	such	ADJ
gs-3446	598	10	mismatches	mismatch	NOUN
gs-3446	598	11	,	,	PUNCT
gs-3446	598	12	but	but	CCONJ
gs-3446	598	13	internal	internal	ADJ
gs-3446	598	14	mechanisms	mechanism	NOUN
gs-3446	598	15	fail	fail	VERB
gs-3446	598	16	to	to	PART
gs-3446	598	17	explain	explain	VERB
gs-3446	598	18	phenomena	phenomenon	NOUN
gs-3446	598	19	like	like	ADP
gs-3446	598	20	size	size	NOUN
gs-3446	598	21	-	-	PUNCT
gs-3446	598	22	dependent	dependent	ADJ
gs-3446	598	23	reproductive	reproductive	ADJ
gs-3446	598	24	organ	organ	NOUN
gs-3446	598	25	differentiation	differentiation	NOUN
gs-3446	598	26	(	(	PUNCT
gs-3446	598	27	newmark	newmark	PROPN
gs-3446	598	28	et	et	PROPN
gs-3446	598	29	al	al	PROPN
gs-3446	598	30	.	.	PROPN
gs-3446	598	31	2008	2008	NUM
gs-3446	598	32	)	)	PUNCT
gs-3446	598	33	or	or	CCONJ
gs-3446	598	34	fluctuating	fluctuate	VERB
gs-3446	598	35	epithelial	epithelial	ADJ
gs-3446	598	36	cell	cell	NOUN
gs-3446	598	37	demands	demand	NOUN
gs-3446	598	38	during	during	ADP
gs-3446	598	39	growth	growth	NOUN
gs-3446	598	40	and	and	CCONJ
gs-3446	598	41	degradation	degradation	NOUN
gs-3446	598	42	.	.	PUNCT
gs-3446	599	1	both	both	DET
gs-3446	599	2	scenarios	scenario	NOUN
gs-3446	599	3	face	face	VERB
gs-3446	599	4	conceptual	conceptual	ADJ
gs-3446	599	5	challenges	challenge	NOUN
gs-3446	599	6	as	as	SCONJ
gs-3446	599	7	they	they	PRON
gs-3446	599	8	propose	propose	VERB
gs-3446	599	9	terminal	terminal	ADJ
gs-3446	599	10	cell	cell	NOUN
gs-3446	599	11	fate	fate	NOUN
gs-3446	599	12	specification	specification	NOUN
gs-3446	599	13	at	at	ADP
gs-3446	599	14	a	a	DET
gs-3446	599	15	single	single	ADJ
gs-3446	599	16	checkpoint	checkpoint	NOUN
gs-3446	599	17	.	.	PUNCT
gs-3446	600	1	however	however	ADV
gs-3446	600	2	,	,	PUNCT
gs-3446	600	3	a	a	DET
gs-3446	600	4	single	single	ADJ
gs-3446	600	5	checkpoint	checkpoint	NOUN
gs-3446	600	6	seems	seem	VERB
gs-3446	600	7	implausible	implausible	ADJ
gs-3446	600	8	given	give	VERB
gs-3446	600	9	the	the	DET
gs-3446	600	10	vast	vast	ADJ
gs-3446	600	11	diversity	diversity	NOUN
gs-3446	600	12	of	of	ADP
gs-3446	600	13	cell	cell	NOUN
gs-3446	600	14	types	type	NOUN
gs-3446	600	15	.	.	PUNCT
gs-3446	601	1	furthermore	furthermore	ADV
gs-3446	601	2	,	,	PUNCT
gs-3446	601	3	embryonic	embryonic	ADJ
gs-3446	601	4	cell	cell	NOUN
gs-3446	601	5	fate	fate	NOUN
gs-3446	601	6	decisions	decision	NOUN
gs-3446	601	7	result	result	VERB
gs-3446	601	8	from	from	ADP
gs-3446	601	9	progressive	progressive	ADJ
gs-3446	601	10	differentiation	differentiation	NOUN
gs-3446	601	11	restrictions	restriction	NOUN
gs-3446	601	12	via	via	ADP
gs-3446	601	13	multiple	multiple	ADJ
gs-3446	601	14	signaling	signal	VERB
gs-3446	601	15	inputs	input	NOUN
gs-3446	601	16	.	.	PUNCT
gs-3446	602	1	hierarchical	hierarchical	ADJ
gs-3446	602	2	lineage	lineage	NOUN
gs-3446	602	3	organization	organization	NOUN
gs-3446	602	4	is	be	AUX
gs-3446	602	5	,	,	PUNCT
gs-3446	602	6	therefore	therefore	ADV
gs-3446	602	7	,	,	PUNCT
gs-3446	602	8	a	a	DET
gs-3446	602	9	plausible	plausible	ADJ
gs-3446	602	10	model	model	NOUN
gs-3446	602	11	(	(	PUNCT
gs-3446	602	12	baguñà	baguñà	NOUN
gs-3446	602	13	et	et	PROPN
gs-3446	602	14	al	al	PROPN
gs-3446	602	15	.	.	PROPN
gs-3446	602	16	1990	1990	NUM
gs-3446	602	17	)	)	PUNCT
gs-3446	602	18	,	,	PUNCT
gs-3446	602	19	incorporating	incorporate	VERB
gs-3446	602	20	broad	broad	ADJ
gs-3446	602	21	lineage	lineage	NOUN
gs-3446	602	22	constraints	constraint	NOUN
gs-3446	602	23	(	(	PUNCT
gs-3446	602	24	e.g.	e.g.	ADV
gs-3446	602	25	,	,	PUNCT
gs-3446	602	26	"	"	PUNCT
gs-3446	602	27	neuronal	neuronal	ADJ
gs-3446	602	28	,	,	PUNCT
gs-3446	602	29	"	"	PUNCT
gs-3446	602	30	"	"	PUNCT
gs-3446	602	31	intestinal	intestinal	ADJ
gs-3446	602	32	,	,	PUNCT
gs-3446	602	33	"	"	PUNCT
gs-3446	602	34	"	"	PUNCT
gs-3446	602	35	muscular	muscular	ADJ
gs-3446	602	36	"	"	PUNCT
gs-3446	602	37	)	)	PUNCT
gs-3446	602	38	at	at	ADP
gs-3446	602	39	higher	high	ADJ
gs-3446	602	40	levels	level	NOUN
gs-3446	602	41	and	and	CCONJ
gs-3446	602	42	refined	refined	ADJ
gs-3446	602	43	terminal	terminal	ADJ
gs-3446	602	44	fate	fate	NOUN
gs-3446	602	45	decisions	decision	NOUN
gs-3446	602	46	(	(	PUNCT
gs-3446	602	47	e.g.	e.g.	ADV
gs-3446	602	48	,	,	PUNCT
gs-3446	602	49	specific	specific	ADJ
gs-3446	602	50	neuronal	neuronal	ADJ
gs-3446	602	51	subtypes	subtype	NOUN
gs-3446	602	52	)	)	PUNCT
gs-3446	602	53	at	at	ADP
gs-3446	602	54	later	later	ADJ
gs-3446	602	55	differentiation	differentiation	NOUN
gs-3446	602	56	stages	stage	NOUN
gs-3446	602	57	.	.	PUNCT
gs-3446	603	1	observed	observe	VERB
gs-3446	603	2	expression	expression	NOUN
gs-3446	603	3	patterns	pattern	NOUN
gs-3446	603	4	,	,	PUNCT
gs-3446	603	5	such	such	ADJ
gs-3446	603	6	as	as	ADP
gs-3446	603	7	smed	sme	VERB
gs-3446	603	8	-	-	PUNCT
gs-3446	603	9	tyrosinase	tyrosinase	NOUN
gs-3446	603	10	in	in	ADP
gs-3446	603	11	regenerating	regenerate	VERB
gs-3446	603	12	planarian	planarian	ADJ
gs-3446	603	13	eyes	eye	NOUN
gs-3446	603	14	,	,	PUNCT
gs-3446	603	15	align	align	VERB
gs-3446	603	16	with	with	ADP
gs-3446	603	17	this	this	DET
gs-3446	603	18	model	model	NOUN
gs-3446	603	19	.	.	PUNCT
gs-3446	604	1	notably	notably	ADV
gs-3446	604	2	,	,	PUNCT
gs-3446	604	3	cell	cell	NOUN
gs-3446	604	4	fate	fate	NOUN
gs-3446	604	5	decisions	decision	NOUN
gs-3446	604	6	occur	occur	VERB
gs-3446	604	7	incrementally	incrementally	ADV
gs-3446	604	8	through	through	ADP
gs-3446	604	9	multiple	multiple	ADJ
gs-3446	604	10	intermediate	intermediate	ADJ
gs-3446	604	11	checkpoints	checkpoint	NOUN
gs-3446	604	12	rather	rather	ADV
gs-3446	604	13	than	than	ADP
gs-3446	604	14	instantaneously	instantaneously	ADV
gs-3446	604	15	.	.	PUNCT
gs-3446	605	1	hierarchical	hierarchical	ADJ
gs-3446	605	2	differentiation	differentiation	NOUN
gs-3446	605	3	integrates	integrate	VERB
gs-3446	605	4	intrinsic	intrinsic	ADJ
gs-3446	605	5	and	and	CCONJ
gs-3446	605	6	signaling	signaling	ADJ
gs-3446	605	7	-	-	PUNCT
gs-3446	605	8	mediated	mediate	VERB
gs-3446	605	9	fate	fate	NOUN
gs-3446	605	10	determination	determination	NOUN
gs-3446	605	11	across	across	ADP
gs-3446	605	12	checkpoints	checkpoint	NOUN
gs-3446	605	13	,	,	PUNCT
gs-3446	605	14	balancing	balance	VERB
gs-3446	605	15	stability	stability	NOUN
gs-3446	605	16	and	and	CCONJ
gs-3446	605	17	flexibility	flexibility	NOUN
gs-3446	605	18	.	.	PUNCT
gs-3446	606	1	initial	initial	ADJ
gs-3446	606	2	lineage	lineage	NOUN
gs-3446	606	3	selection	selection	NOUN
gs-3446	606	4	via	via	ADP
gs-3446	606	5	intrinsic	intrinsic	ADJ
gs-3446	606	6	mechanisms	mechanism	NOUN
gs-3446	606	7	,	,	PUNCT
gs-3446	606	8	such	such	ADJ
gs-3446	606	9	as	as	ADP
gs-3446	606	10	stochastic	stochastic	ADJ
gs-3446	606	11	retinal	retinal	ADJ
gs-3446	606	12	progenitor	progenitor	NOUN
gs-3446	606	13	fate	fate	NOUN
gs-3446	606	14	choices	choice	NOUN
gs-3446	606	15	(	(	PUNCT
gs-3446	606	16	gomes	gome	NOUN
gs-3446	606	17	et	et	PROPN
gs-3446	606	18	al	al	PROPN
gs-3446	606	19	.	.	PROPN
gs-3446	606	20	2011	2011	NUM
gs-3446	606	21	)	)	PUNCT
gs-3446	606	22	,	,	PUNCT
gs-3446	606	23	ensures	ensure	VERB
gs-3446	606	24	long	long	ADJ
gs-3446	606	25	-	-	PUNCT
gs-3446	606	26	term	term	NOUN
gs-3446	606	27	lineage	lineage	NOUN
gs-3446	606	28	stability	stability	NOUN
gs-3446	606	29	.	.	PUNCT
gs-3446	607	1	the	the	DET
gs-3446	607	2	concern	concern	NOUN
gs-3446	607	3	of	of	ADP
gs-3446	607	4	inappropriate	inappropriate	ADJ
gs-3446	607	5	progenitors	progenitor	NOUN
gs-3446	607	6	becomes	become	VERB
gs-3446	607	7	less	less	ADV
gs-3446	607	8	significant	significant	ADJ
gs-3446	607	9	with	with	ADP
gs-3446	607	10	broader	broad	ADJ
gs-3446	607	11	initial	initial	ADJ
gs-3446	607	12	lineage	lineage	NOUN
gs-3446	607	13	selections	selection	NOUN
gs-3446	607	14	.	.	PUNCT
gs-3446	608	1	progenitor	progenitor	NOUN
gs-3446	608	2	fate	fate	NOUN
gs-3446	608	3	choices	choice	NOUN
gs-3446	608	4	how	how	SCONJ
gs-3446	608	5	regeneration	regeneration	NOUN
gs-3446	608	6	restores	restore	VERB
gs-3446	608	7	precisely	precisely	ADV
gs-3446	608	8	what	what	PRON
gs-3446	608	9	is	be	AUX
gs-3446	608	10	missing	miss	VERB
gs-3446	608	11	remains	remain	VERB
gs-3446	608	12	unclear	unclear	ADJ
gs-3446	608	13	.	.	PUNCT
gs-3446	609	1	these	these	DET
gs-3446	609	2	phenomena	phenomenon	NOUN
gs-3446	609	3	imply	imply	VERB
gs-3446	609	4	global	global	ADJ
gs-3446	609	5	body	body	NOUN
gs-3446	609	6	patterning	pattern	VERB
gs-3446	609	7	signals	signal	NOUN
gs-3446	609	8	influencing	influence	VERB
gs-3446	609	9	local	local	ADJ
gs-3446	609	10	fate	fate	NOUN
gs-3446	609	11	decisions	decision	NOUN
gs-3446	609	12	(	(	PUNCT
gs-3446	609	13	lobo	lobo	NOUN
gs-3446	609	14	et	et	PROPN
gs-3446	609	15	al	al	PROPN
gs-3446	609	16	.	.	PROPN
gs-3446	609	17	2012	2012	NUM
gs-3446	609	18	)	)	PUNCT
gs-3446	609	19	.	.	PUNCT
gs-3446	610	1	while	while	SCONJ
gs-3446	610	2	mechanistic	mechanistic	ADJ
gs-3446	610	3	details	detail	NOUN
gs-3446	610	4	are	be	AUX
gs-3446	610	5	lacking	lack	VERB
gs-3446	610	6	,	,	PUNCT
gs-3446	610	7	altered	alter	VERB
gs-3446	610	8	smed	sme	VERB
gs-3446	610	9	-	-	PUNCT
gs-3446	610	10	β	β	NOUN
gs-3446	610	11	-	-	PUNCT
gs-3446	610	12	catenin-1	catenin-1	NUM
gs-3446	610	13	activity	activity	NOUN
gs-3446	610	14	highlights	highlight	NOUN
gs-3446	610	15	conceptual	conceptual	ADJ
gs-3446	610	16	importance	importance	NOUN
gs-3446	610	17	.	.	PUNCT
gs-3446	611	1	β	β	X
gs-3446	611	2	-	-	ADJ
gs-3446	611	3	catenin	catenin	ADJ
gs-3446	611	4	functions	function	NOUN
gs-3446	611	5	as	as	ADP
gs-3446	611	6	an	an	DET
gs-3446	611	7	intracellular	intracellular	ADJ
gs-3446	611	8	effector	effector	NOUN
gs-3446	611	9	of	of	ADP
gs-3446	611	10	canonical	canonical	ADJ
gs-3446	611	11	wnt	wnt	NOUN
gs-3446	611	12	signaling	signal	VERB
gs-3446	611	13	(	(	PUNCT
gs-3446	611	14	clevers	clever	NOUN
gs-3446	611	15	and	and	CCONJ
gs-3446	611	16	nusse	nusse	PROPN
gs-3446	611	17	2012	2012	NUM
gs-3446	611	18	)	)	PUNCT
gs-3446	611	19	.	.	PUNCT
gs-3446	612	1	reduced	reduce	VERB
gs-3446	612	2	smed	sme	VERB
gs-3446	612	3	-	-	PUNCT
gs-3446	612	4	βcatenin-1	βcatenin-1	NUM
gs-3446	612	5	activity	activity	NOUN
gs-3446	612	6	induces	induce	VERB
gs-3446	612	7	head	head	NOUN
gs-3446	612	8	regeneration	regeneration	NOUN
gs-3446	612	9	regardless	regardless	ADV
gs-3446	612	10	of	of	ADP
gs-3446	612	11	wound	wound	ADJ
gs-3446	612	12	context	context	NOUN
gs-3446	612	13	,	,	PUNCT
gs-3446	612	14	while	while	SCONJ
gs-3446	612	15	increased	increased	ADJ
gs-3446	612	16	activity	activity	NOUN
gs-3446	612	17	dominantly	dominantly	ADV
gs-3446	612	18	induces	induce	VERB
gs-3446	612	19	tail	tail	NOUN
gs-3446	612	20	regeneration	regeneration	NOUN
gs-3446	612	21	(	(	PUNCT
gs-3446	612	22	gurley	gurley	PROPN
gs-3446	612	23	et	et	PROPN
gs-3446	612	24	al	al	PROPN
gs-3446	612	25	.	.	PROPN
gs-3446	612	26	2008	2008	NUM
gs-3446	612	27	)	)	PUNCT
gs-3446	612	28	.	.	PUNCT
gs-3446	613	1	these	these	DET
gs-3446	613	2	phenotypes	phenotype	NOUN
gs-3446	613	3	suggest	suggest	VERB
gs-3446	613	4	that	that	SCONJ
gs-3446	613	5	β	β	X
gs-3446	613	6	-	-	SYM
gs-3446	613	7	catenin-1	catenin-1	NUM
gs-3446	613	8	acts	act	NOUN
gs-3446	613	9	as	as	ADP
gs-3446	613	10	a	a	DET
gs-3446	613	11	binary	binary	ADJ
gs-3446	613	12	switch	switch	NOUN
gs-3446	613	13	high	high	ADV
gs-3446	613	14	in	in	ADP
gs-3446	613	15	the	the	DET
gs-3446	613	16	tissue	tissue	NOUN
gs-3446	613	17	fate	fate	NOUN
gs-3446	613	18	hierarchy	hierarchy	NOUN
gs-3446	613	19	rather	rather	ADV
gs-3446	613	20	than	than	ADP
gs-3446	613	21	a	a	DET
gs-3446	613	22	simple	simple	ADJ
gs-3446	613	23	internal	internal	ADJ
gs-3446	613	24	determinant	determinant	ADJ
gs-3446	613	25	.	.	PUNCT
gs-3446	614	1	embryonic	embryonic	ADJ
gs-3446	614	2	organizers	organizer	NOUN
gs-3446	614	3	provide	provide	VERB
gs-3446	614	4	a	a	DET
gs-3446	614	5	paradigm	paradigm	NOUN
gs-3446	614	6	for	for	ADP
gs-3446	614	7	such	such	ADJ
gs-3446	614	8	mechanisms	mechanism	NOUN
gs-3446	614	9	.	.	PUNCT
gs-3446	615	1	organizers	organizer	NOUN
gs-3446	615	2	are	be	AUX
gs-3446	615	3	self	self	NOUN
gs-3446	615	4	-	-	PUNCT
gs-3446	615	5	sustaining	sustain	VERB
gs-3446	615	6	signaling	signal	VERB
gs-3446	615	7	centers	center	NOUN
gs-3446	615	8	(	(	PUNCT
gs-3446	615	9	often	often	ADV
gs-3446	615	10	involving	involve	VERB
gs-3446	615	11	β	β	NOUN
gs-3446	615	12	-	-	NOUN
gs-3446	615	13	catenin	catenin	NOUN
gs-3446	615	14	)	)	PUNCT
gs-3446	615	15	that	that	PRON
gs-3446	615	16	establish	establish	VERB
gs-3446	615	17	embryonic	embryonic	ADJ
gs-3446	615	18	axes	axis	NOUN
gs-3446	615	19	(	(	PUNCT
gs-3446	615	20	de	de	X
gs-3446	615	21	robertis	robertis	NOUN
gs-3446	615	22	2009	2009	NUM
gs-3446	615	23	)	)	PUNCT
gs-3446	615	24	.	.	PUNCT
gs-3446	616	1	their	their	PRON
gs-3446	616	2	georgian	georgian	ADJ
gs-3446	616	3	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3446	616	4	მეცნიერები	მეცნიერები	NOUN
gs-3446	616	5	ტ.	ტ.	VERB
gs-3446	616	6	7	7	NUM
gs-3446	616	7	n	n	PRON
gs-3446	616	8	1	1	NUM
gs-3446	616	9	,	,	PUNCT
gs-3446	616	10	2025	2025	NUM
gs-3446	616	11	309	309	NUM
gs-3446	616	12	relevance	relevance	NOUN
gs-3446	616	13	to	to	ADP
gs-3446	616	14	planarian	planarian	ADJ
gs-3446	616	15	regeneration	regeneration	NOUN
gs-3446	616	16	lies	lie	VERB
gs-3446	616	17	in	in	ADP
gs-3446	616	18	their	their	PRON
gs-3446	616	19	self	self	NOUN
gs-3446	616	20	-	-	PUNCT
gs-3446	616	21	organization	organization	NOUN
gs-3446	616	22	based	base	VERB
gs-3446	616	23	on	on	ADP
gs-3446	616	24	dynamic	dynamic	ADJ
gs-3446	616	25	cell	cell	NOUN
gs-3446	616	26	interactions	interaction	NOUN
gs-3446	616	27	(	(	PUNCT
gs-3446	616	28	meinhardt	meinhardt	NOUN
gs-3446	616	29	2009	2009	NUM
gs-3446	616	30	)	)	PUNCT
gs-3446	616	31	and	and	CCONJ
gs-3446	616	32	their	their	PRON
gs-3446	616	33	ability	ability	NOUN
gs-3446	616	34	to	to	PART
gs-3446	616	35	spatially	spatially	ADV
gs-3446	616	36	direct	direct	ADJ
gs-3446	616	37	lineage	lineage	NOUN
gs-3446	616	38	selection	selection	NOUN
gs-3446	616	39	(	(	PUNCT
gs-3446	616	40	niehrs	niehrs	NOUN
gs-3446	616	41	2004	2004	NUM
gs-3446	616	42	)	)	PUNCT
gs-3446	616	43	.	.	PUNCT
gs-3446	617	1	smed	sme	VERB
gs-3446	617	2	-	-	PUNCT
gs-3446	617	3	β	β	NOUN
gs-3446	617	4	-	-	PUNCT
gs-3446	617	5	catenin1	catenin1	NOUN
gs-3446	617	6	may	may	AUX
gs-3446	617	7	select	select	VERB
gs-3446	617	8	between	between	ADP
gs-3446	617	9	self	self	NOUN
gs-3446	617	10	-	-	PUNCT
gs-3446	617	11	sustaining	sustain	VERB
gs-3446	617	12	signaling	signal	VERB
gs-3446	617	13	systems	system	NOUN
gs-3446	617	14	promoting	promote	VERB
gs-3446	617	15	tail	tail	NOUN
gs-3446	617	16	or	or	CCONJ
gs-3446	617	17	head	head	NOUN
gs-3446	617	18	regeneration	regeneration	NOUN
gs-3446	617	19	,	,	PUNCT
gs-3446	617	20	organizing	organize	VERB
gs-3446	617	21	progenitor	progenitor	NOUN
gs-3446	617	22	differentiation	differentiation	NOUN
gs-3446	617	23	spatially	spatially	ADV
gs-3446	617	24	and	and	CCONJ
gs-3446	617	25	temporally	temporally	ADV
gs-3446	617	26	.	.	PUNCT
gs-3446	618	1	patterning	pattern	VERB
gs-3446	618	2	signals	signal	NOUN
gs-3446	618	3	influencing	influence	VERB
gs-3446	618	4	lineage	lineage	NOUN
gs-3446	618	5	choices	choice	NOUN
gs-3446	618	6	require	require	VERB
gs-3446	618	7	regional	regional	ADJ
gs-3446	618	8	fate	fate	NOUN
gs-3446	618	9	determinants	determinant	NOUN
gs-3446	618	10	or	or	CCONJ
gs-3446	618	11	competence	competence	NOUN
gs-3446	618	12	mediators	mediator	NOUN
gs-3446	618	13	.	.	PUNCT
gs-3446	619	1	examples	example	NOUN
gs-3446	619	2	include	include	VERB
gs-3446	619	3	lim	lim	PROPN
gs-3446	619	4	-	-	PUNCT
gs-3446	619	5	homeodomain	homeodomain	NOUN
gs-3446	619	6	transcription	transcription	NOUN
gs-3446	619	7	factor	factor	NOUN
gs-3446	619	8	dj	dj	NOUN
gs-3446	619	9	-	-	PUNCT
gs-3446	619	10	islet	islet	NOUN
gs-3446	619	11	,	,	PUNCT
gs-3446	619	12	essential	essential	ADJ
gs-3446	619	13	for	for	ADP
gs-3446	619	14	tail	tail	NOUN
gs-3446	619	15	regeneration	regeneration	NOUN
gs-3446	619	16	and	and	CCONJ
gs-3446	619	17	maintaining	maintain	VERB
gs-3446	619	18	wnt	wnt	NOUN
gs-3446	619	19	ligand	ligand	NOUN
gs-3446	619	20	expression	expression	NOUN
gs-3446	619	21	(	(	PUNCT
gs-3446	619	22	hayashi	hayashi	PROPN
gs-3446	619	23	et	et	PROPN
gs-3446	619	24	al	al	PROPN
gs-3446	619	25	.	.	PROPN
gs-3446	619	26	2011	2011	NUM
gs-3446	619	27	)	)	PUNCT
gs-3446	619	28	,	,	PUNCT
gs-3446	619	29	and	and	CCONJ
gs-3446	619	30	tale	tale	ADJ
gs-3446	619	31	-	-	PUNCT
gs-3446	619	32	homeobox	homeobox	NOUN
gs-3446	619	33	gene	gene	NOUN
gs-3446	619	34	smed	sme	VERB
gs-3446	619	35	-	-	PUNCT
gs-3446	619	36	prep	prep	NOUN
gs-3446	619	37	,	,	PUNCT
gs-3446	619	38	necessary	necessary	ADJ
gs-3446	619	39	for	for	ADP
gs-3446	619	40	head	head	NOUN
gs-3446	619	41	induction	induction	NOUN
gs-3446	619	42	downstream	downstream	NOUN
gs-3446	619	43	of	of	ADP
gs-3446	619	44	β	β	X
gs-3446	619	45	-	-	SYM
gs-3446	619	46	catenin-1	catenin-1	PROPN
gs-3446	619	47	(	(	PUNCT
gs-3446	619	48	felix	felix	PROPN
gs-3446	619	49	and	and	CCONJ
gs-3446	619	50	aboobaker	aboobaker	NOUN
gs-3446	619	51	2010	2010	NUM
gs-3446	619	52	)	)	PUNCT
gs-3446	619	53	.	.	PUNCT
gs-3446	620	1	these	these	DET
gs-3446	620	2	genes	gene	NOUN
gs-3446	620	3	may	may	AUX
gs-3446	620	4	function	function	VERB
gs-3446	620	5	as	as	ADP
gs-3446	620	6	selectors	selector	NOUN
gs-3446	620	7	for	for	ADP
gs-3446	620	8	regional	regional	ADJ
gs-3446	620	9	identities	identity	NOUN
gs-3446	620	10	.	.	PUNCT
gs-3446	621	1	progenitors	progenitor	NOUN
gs-3446	621	2	differentiate	differentiate	VERB
gs-3446	621	3	in	in	ADP
gs-3446	621	4	response	response	NOUN
gs-3446	621	5	to	to	ADP
gs-3446	621	6	patterning	pattern	VERB
gs-3446	621	7	signals	signal	NOUN
gs-3446	621	8	,	,	PUNCT
gs-3446	621	9	which	which	PRON
gs-3446	621	10	themselves	themselves	PRON
gs-3446	621	11	are	be	AUX
gs-3446	621	12	produced	produce	VERB
gs-3446	621	13	by	by	ADP
gs-3446	621	14	differentiated	differentiated	ADJ
gs-3446	621	15	cells	cell	NOUN
gs-3446	621	16	,	,	PUNCT
gs-3446	621	17	forming	form	VERB
gs-3446	621	18	a	a	DET
gs-3446	621	19	self	self	NOUN
gs-3446	621	20	-	-	PUNCT
gs-3446	621	21	reinforcing	reinforce	VERB
gs-3446	621	22	loop	loop	NOUN
gs-3446	621	23	.	.	PUNCT
gs-3446	622	1	thus	thus	ADV
gs-3446	622	2	,	,	PUNCT
gs-3446	622	3	cell	cell	NOUN
gs-3446	622	4	fate	fate	NOUN
gs-3446	622	5	specification	specification	NOUN
gs-3446	622	6	is	be	AUX
gs-3446	622	7	both	both	PRON
gs-3446	622	8	an	an	DET
gs-3446	622	9	endpoint	endpoint	NOUN
gs-3446	622	10	and	and	CCONJ
gs-3446	622	11	a	a	DET
gs-3446	622	12	starting	starting	NOUN
gs-3446	622	13	point	point	NOUN
gs-3446	622	14	,	,	PUNCT
gs-3446	622	15	perpetuating	perpetuate	VERB
gs-3446	622	16	developmental	developmental	ADJ
gs-3446	622	17	patterns	pattern	NOUN
gs-3446	622	18	.	.	PUNCT
gs-3446	623	1	self	self	NOUN
gs-3446	623	2	-	-	PUNCT
gs-3446	623	3	renewal	renewal	NOUN
gs-3446	623	4	of	of	ADP
gs-3446	623	5	tissues	tissue	NOUN
gs-3446	623	6	tissue	tissue	NOUN
gs-3446	623	7	self	self	NOUN
gs-3446	623	8	-	-	PUNCT
gs-3446	623	9	renewal	renewal	NOUN
gs-3446	623	10	is	be	AUX
gs-3446	623	11	a	a	DET
gs-3446	623	12	fundamental	fundamental	ADJ
gs-3446	623	13	process	process	NOUN
gs-3446	623	14	that	that	PRON
gs-3446	623	15	maintains	maintain	VERB
gs-3446	623	16	homeostasis	homeostasis	NOUN
gs-3446	623	17	and	and	CCONJ
gs-3446	623	18	ensures	ensure	VERB
gs-3446	623	19	repair	repair	NOUN
gs-3446	623	20	following	follow	VERB
gs-3446	623	21	apoptosis	apoptosis	NOUN
gs-3446	623	22	or	or	CCONJ
gs-3446	623	23	injury	injury	NOUN
gs-3446	623	24	.	.	PUNCT
gs-3446	624	1	it	it	PRON
gs-3446	624	2	involves	involve	VERB
gs-3446	624	3	tightly	tightly	ADV
gs-3446	624	4	regulated	regulate	VERB
gs-3446	624	5	mechanisms	mechanism	NOUN
gs-3446	624	6	driven	drive	VERB
gs-3446	624	7	by	by	ADP
gs-3446	624	8	stem	stem	NOUN
gs-3446	624	9	and	and	CCONJ
gs-3446	624	10	progenitor	progenitor	NOUN
gs-3446	624	11	cells	cell	NOUN
gs-3446	624	12	,	,	PUNCT
gs-3446	624	13	which	which	PRON
gs-3446	624	14	possess	possess	VERB
gs-3446	624	15	the	the	DET
gs-3446	624	16	ability	ability	NOUN
gs-3446	624	17	to	to	PART
gs-3446	624	18	proliferate	proliferate	VERB
gs-3446	624	19	and	and	CCONJ
gs-3446	624	20	differentiate	differentiate	VERB
gs-3446	624	21	.	.	PUNCT
gs-3446	625	1	the	the	DET
gs-3446	625	2	ability	ability	NOUN
gs-3446	625	3	of	of	ADP
gs-3446	625	4	tissues	tissue	NOUN
gs-3446	625	5	to	to	ADP
gs-3446	625	6	self	self	NOUN
gs-3446	625	7	-	-	PUNCT
gs-3446	625	8	renew	renew	NOUN
gs-3446	625	9	is	be	AUX
gs-3446	625	10	essential	essential	ADJ
gs-3446	625	11	for	for	ADP
gs-3446	625	12	maintaining	maintain	VERB
gs-3446	625	13	physiological	physiological	ADJ
gs-3446	625	14	balance	balance	NOUN
gs-3446	625	15	and	and	CCONJ
gs-3446	625	16	functional	functional	ADJ
gs-3446	625	17	longevity	longevity	NOUN
gs-3446	625	18	.	.	PUNCT
gs-3446	626	1	this	this	DET
gs-3446	626	2	process	process	NOUN
gs-3446	626	3	depends	depend	VERB
gs-3446	626	4	on	on	ADP
gs-3446	626	5	a	a	DET
gs-3446	626	6	dynamic	dynamic	ADJ
gs-3446	626	7	interplay	interplay	NOUN
gs-3446	626	8	between	between	ADP
gs-3446	626	9	cellular	cellular	ADJ
gs-3446	626	10	proliferation	proliferation	NOUN
gs-3446	626	11	,	,	PUNCT
gs-3446	626	12	differentiation	differentiation	NOUN
gs-3446	626	13	,	,	PUNCT
gs-3446	626	14	and	and	CCONJ
gs-3446	626	15	apoptosis	apoptosis	NOUN
gs-3446	626	16	.	.	PUNCT
gs-3446	627	1	stem	stem	NOUN
gs-3446	627	2	cells	cell	NOUN
gs-3446	627	3	play	play	VERB
gs-3446	627	4	a	a	DET
gs-3446	627	5	central	central	ADJ
gs-3446	627	6	role	role	NOUN
gs-3446	627	7	in	in	ADP
gs-3446	627	8	self	self	NOUN
gs-3446	627	9	-	-	PUNCT
gs-3446	627	10	renewal	renewal	NOUN
gs-3446	627	11	due	due	ADP
gs-3446	627	12	to	to	ADP
gs-3446	627	13	their	their	PRON
gs-3446	627	14	capacity	capacity	NOUN
gs-3446	627	15	for	for	ADP
gs-3446	627	16	asymmetric	asymmetric	ADJ
gs-3446	627	17	division	division	NOUN
gs-3446	627	18	,	,	PUNCT
gs-3446	627	19	enabling	enable	VERB
gs-3446	627	20	both	both	DET
gs-3446	627	21	self	self	NOUN
gs-3446	627	22	-	-	PUNCT
gs-3446	627	23	replication	replication	NOUN
gs-3446	627	24	and	and	CCONJ
gs-3446	627	25	the	the	DET
gs-3446	627	26	generation	generation	NOUN
gs-3446	627	27	of	of	ADP
gs-3446	627	28	specialized	specialized	ADJ
gs-3446	627	29	cell	cell	NOUN
gs-3446	627	30	types	type	NOUN
gs-3446	627	31	.	.	PUNCT
gs-3446	628	1	stem	stem	NOUN
gs-3446	628	2	cells	cell	NOUN
gs-3446	628	3	are	be	AUX
gs-3446	628	4	categorized	categorize	VERB
gs-3446	628	5	into	into	ADP
gs-3446	628	6	embryonic	embryonic	ADJ
gs-3446	628	7	and	and	CCONJ
gs-3446	628	8	adult	adult	NOUN
gs-3446	628	9	stem	stem	NOUN
gs-3446	628	10	cells	cell	NOUN
gs-3446	628	11	,	,	PUNCT
gs-3446	628	12	with	with	ADP
gs-3446	628	13	the	the	DET
gs-3446	628	14	latter	latter	ADJ
gs-3446	628	15	being	be	AUX
gs-3446	628	16	responsible	responsible	ADJ
gs-3446	628	17	for	for	ADP
gs-3446	628	18	tissue	tissue	NOUN
gs-3446	628	19	maintenance	maintenance	NOUN
gs-3446	628	20	.	.	PUNCT
gs-3446	629	1	adult	adult	NOUN
gs-3446	629	2	stem	stem	NOUN
gs-3446	629	3	cells	cell	NOUN
gs-3446	629	4	reside	reside	VERB
gs-3446	629	5	in	in	ADP
gs-3446	629	6	niches	niche	NOUN
gs-3446	629	7	that	that	PRON
gs-3446	629	8	provide	provide	VERB
gs-3446	629	9	structural	structural	ADJ
gs-3446	629	10	and	and	CCONJ
gs-3446	629	11	biochemical	biochemical	ADJ
gs-3446	629	12	support	support	NOUN
gs-3446	629	13	,	,	PUNCT
gs-3446	629	14	preserving	preserve	VERB
gs-3446	629	15	their	their	PRON
gs-3446	629	16	quiescence	quiescence	NOUN
gs-3446	629	17	and	and	CCONJ
gs-3446	629	18	multipotency	multipotency	NOUN
gs-3446	629	19	.	.	PUNCT
gs-3446	630	1	asymmetric	asymmetric	ADJ
gs-3446	630	2	division	division	NOUN
gs-3446	630	3	allows	allow	VERB
gs-3446	630	4	stem	stem	NOUN
gs-3446	630	5	cells	cell	NOUN
gs-3446	630	6	to	to	PART
gs-3446	630	7	produce	produce	VERB
gs-3446	630	8	one	one	NUM
gs-3446	630	9	daughter	daughter	NOUN
gs-3446	630	10	cell	cell	NOUN
gs-3446	630	11	that	that	PRON
gs-3446	630	12	retains	retain	VERB
gs-3446	630	13	stem	stem	NOUN
gs-3446	630	14	-	-	PUNCT
gs-3446	630	15	like	like	ADJ
gs-3446	630	16	properties	property	NOUN
gs-3446	630	17	and	and	CCONJ
gs-3446	630	18	another	another	PRON
gs-3446	630	19	that	that	SCONJ
gs-3446	630	20	differentiates	differentiate	VERB
gs-3446	630	21	.	.	PUNCT
gs-3446	631	1	this	this	DET
gs-3446	631	2	division	division	NOUN
gs-3446	631	3	is	be	AUX
gs-3446	631	4	regulated	regulate	VERB
gs-3446	631	5	by	by	ADP
gs-3446	631	6	polarity	polarity	NOUN
gs-3446	631	7	proteins	protein	NOUN
gs-3446	631	8	,	,	PUNCT
gs-3446	631	9	centrosome	centrosome	NOUN
gs-3446	631	10	inheritance	inheritance	NOUN
gs-3446	631	11	,	,	PUNCT
gs-3446	631	12	and	and	CCONJ
gs-3446	631	13	spindle	spindle	NOUN
gs-3446	631	14	orientation	orientation	NOUN
gs-3446	631	15	.	.	PUNCT
gs-3446	632	1	progenitor	progenitor	NOUN
gs-3446	632	2	cells	cell	NOUN
gs-3446	632	3	amplify	amplify	VERB
gs-3446	632	4	tissue	tissue	NOUN
gs-3446	632	5	-	-	PUNCT
gs-3446	632	6	specific	specific	ADJ
gs-3446	632	7	cell	cell	NOUN
gs-3446	632	8	populations	population	NOUN
gs-3446	632	9	through	through	ADP
gs-3446	632	10	transient	transient	ADJ
gs-3446	632	11	proliferation	proliferation	NOUN
gs-3446	632	12	,	,	PUNCT
gs-3446	632	13	followed	follow	VERB
gs-3446	632	14	by	by	ADP
gs-3446	632	15	terminal	terminal	ADJ
gs-3446	632	16	differentiation	differentiation	NOUN
gs-3446	632	17	.	.	PUNCT
gs-3446	633	1	key	key	ADJ
gs-3446	633	2	signaling	signal	VERB
gs-3446	633	3	cascades	cascade	NOUN
gs-3446	633	4	such	such	ADJ
gs-3446	633	5	as	as	ADP
gs-3446	633	6	wnt	wnt	NOUN
gs-3446	633	7	/	/	SYM
gs-3446	633	8	β	β	NOUN
gs-3446	633	9	-	-	ADJ
gs-3446	633	10	catenin	catenin	ADJ
gs-3446	633	11	,	,	PUNCT
gs-3446	633	12	notch	notch	NOUN
gs-3446	633	13	,	,	PUNCT
gs-3446	633	14	and	and	CCONJ
gs-3446	633	15	123	123	NUM
gs-3446	633	16	orchestrate	orchestrate	ADJ
gs-3446	633	17	self	self	NOUN
gs-3446	633	18	-	-	PUNCT
gs-3446	633	19	renewal	renewal	NOUN
gs-3446	633	20	processes	process	NOUN
gs-3446	633	21	by	by	ADP
gs-3446	633	22	modulating	modulate	VERB
gs-3446	633	23	gene	gene	NOUN
gs-3446	633	24	expression	expression	NOUN
gs-3446	633	25	and	and	CCONJ
gs-3446	633	26	cellular	cellular	ADJ
gs-3446	633	27	behavior	behavior	NOUN
gs-3446	633	28	.	.	PUNCT
gs-3446	634	1	epigenetic	epigenetic	ADJ
gs-3446	634	2	regulation	regulation	NOUN
gs-3446	634	3	,	,	PUNCT
gs-3446	634	4	including	include	VERB
gs-3446	634	5	dna	dna	PROPN
gs-3446	634	6	methylation	methylation	NOUN
gs-3446	634	7	and	and	CCONJ
gs-3446	634	8	histone	histone	NOUN
gs-3446	634	9	modifications	modification	NOUN
gs-3446	634	10	,	,	PUNCT
gs-3446	634	11	maintains	maintain	VERB
gs-3446	634	12	the	the	DET
gs-3446	634	13	balance	balance	NOUN
gs-3446	634	14	between	between	ADP
gs-3446	634	15	self	self	NOUN
gs-3446	634	16	-	-	PUNCT
gs-3446	634	17	renewal	renewal	NOUN
gs-3446	634	18	and	and	CCONJ
gs-3446	634	19	differentiation	differentiation	NOUN
gs-3446	634	20	.	.	PUNCT
gs-3446	635	1	georgian	georgian	ADJ
gs-3446	635	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	635	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	635	4	ტ.	ტ.	VERB
gs-3446	635	5	7	7	NUM
gs-3446	635	6	n	n	PRON
gs-3446	635	7	1	1	NUM
gs-3446	635	8	,	,	PUNCT
gs-3446	635	9	2025	2025	NUM
gs-3446	635	10	310	310	NUM
gs-3446	635	11	factors	factor	NOUN
gs-3446	635	12	such	such	ADJ
gs-3446	635	13	as	as	ADP
gs-3446	635	14	oct4	oct4	NOUN
gs-3446	635	15	,	,	PUNCT
gs-3446	635	16	sox2	sox2	NOUN
gs-3446	635	17	,	,	PUNCT
gs-3446	635	18	and	and	CCONJ
gs-3446	635	19	nanog	nanog	PROPN
gs-3446	635	20	sustain	sustain	VERB
gs-3446	635	21	pluripotency	pluripotency	NOUN
gs-3446	635	22	in	in	ADP
gs-3446	635	23	embryonic	embryonic	ADJ
gs-3446	635	24	stem	stem	NOUN
gs-3446	635	25	cells	cell	NOUN
gs-3446	635	26	and	and	CCONJ
gs-3446	635	27	regulate	regulate	VERB
gs-3446	635	28	lineage	lineage	NOUN
gs-3446	635	29	-	-	PUNCT
gs-3446	635	30	specific	specific	ADJ
gs-3446	635	31	commitment	commitment	NOUN
gs-3446	635	32	in	in	ADP
gs-3446	635	33	adult	adult	NOUN
gs-3446	635	34	stem	stem	NOUN
gs-3446	635	35	cells	cell	NOUN
gs-3446	635	36	.	.	PUNCT
gs-3446	636	1	understanding	understand	VERB
gs-3446	636	2	the	the	DET
gs-3446	636	3	regulatory	regulatory	ADJ
gs-3446	636	4	networks	network	NOUN
gs-3446	636	5	of	of	ADP
gs-3446	636	6	tissue	tissue	NOUN
gs-3446	636	7	self	self	NOUN
gs-3446	636	8	-	-	PUNCT
gs-3446	636	9	renewal	renewal	NOUN
gs-3446	636	10	provides	provide	VERB
gs-3446	636	11	insights	insight	NOUN
gs-3446	636	12	into	into	ADP
gs-3446	636	13	maintaining	maintain	VERB
gs-3446	636	14	health	health	NOUN
gs-3446	636	15	and	and	CCONJ
gs-3446	636	16	treating	treat	VERB
gs-3446	636	17	diseases	disease	NOUN
gs-3446	636	18	.	.	PUNCT
gs-3446	637	1	further	further	ADJ
gs-3446	637	2	research	research	NOUN
gs-3446	637	3	into	into	ADP
gs-3446	637	4	niche	niche	NOUN
gs-3446	637	5	dynamics	dynamic	NOUN
gs-3446	637	6	,	,	PUNCT
gs-3446	637	7	signaling	signal	VERB
gs-3446	637	8	pathways	pathway	NOUN
gs-3446	637	9	,	,	PUNCT
gs-3446	637	10	and	and	CCONJ
gs-3446	637	11	epigenetic	epigenetic	ADJ
gs-3446	637	12	controls	control	NOUN
gs-3446	637	13	is	be	AUX
gs-3446	637	14	essential	essential	ADJ
gs-3446	637	15	for	for	ADP
gs-3446	637	16	advancing	advance	VERB
gs-3446	637	17	regenerative	regenerative	ADJ
gs-3446	637	18	medicine	medicine	NOUN
gs-3446	637	19	.	.	PUNCT
gs-3446	638	1	the	the	DET
gs-3446	638	2	problem	problem	NOUN
gs-3446	638	3	of	of	ADP
gs-3446	638	4	decreasing	decrease	VERB
gs-3446	638	5	stem	stem	NOUN
gs-3446	638	6	cell	cell	NOUN
gs-3446	638	7	division	division	NOUN
gs-3446	638	8	rate	rate	NOUN
gs-3446	638	9	over	over	ADP
gs-3446	638	10	time	time	NOUN
gs-3446	638	11	stem	stem	NOUN
gs-3446	638	12	cells	cell	NOUN
gs-3446	638	13	are	be	AUX
gs-3446	638	14	vital	vital	ADJ
gs-3446	638	15	for	for	ADP
gs-3446	638	16	tissue	tissue	NOUN
gs-3446	638	17	maintenance	maintenance	NOUN
gs-3446	638	18	,	,	PUNCT
gs-3446	638	19	regeneration	regeneration	NOUN
gs-3446	638	20	,	,	PUNCT
gs-3446	638	21	and	and	CCONJ
gs-3446	638	22	repair	repair	VERB
gs-3446	638	23	due	due	ADP
gs-3446	638	24	to	to	ADP
gs-3446	638	25	their	their	PRON
gs-3446	638	26	ability	ability	NOUN
gs-3446	638	27	to	to	PART
gs-3446	638	28	self	self	NOUN
gs-3446	638	29	-	-	PUNCT
gs-3446	638	30	renew	renew	NOUN
gs-3446	638	31	and	and	CCONJ
gs-3446	638	32	differentiate	differentiate	VERB
gs-3446	638	33	.	.	PUNCT
gs-3446	639	1	however	however	ADV
gs-3446	639	2	,	,	PUNCT
gs-3446	639	3	a	a	DET
gs-3446	639	4	significant	significant	ADJ
gs-3446	639	5	challenge	challenge	NOUN
gs-3446	639	6	in	in	ADP
gs-3446	639	7	aging	age	VERB
gs-3446	639	8	and	and	CCONJ
gs-3446	639	9	regenerative	regenerative	ADJ
gs-3446	639	10	medicine	medicine	NOUN
gs-3446	639	11	is	be	AUX
gs-3446	639	12	the	the	DET
gs-3446	639	13	progressive	progressive	ADJ
gs-3446	639	14	decline	decline	NOUN
gs-3446	639	15	in	in	ADP
gs-3446	639	16	stem	stem	NOUN
gs-3446	639	17	cell	cell	NOUN
gs-3446	639	18	division	division	NOUN
gs-3446	639	19	rates	rate	NOUN
gs-3446	639	20	over	over	ADP
gs-3446	639	21	time	time	NOUN
gs-3446	639	22	.	.	PUNCT
gs-3446	640	1	this	this	DET
gs-3446	640	2	phenomenon	phenomenon	NOUN
gs-3446	640	3	contributes	contribute	VERB
gs-3446	640	4	to	to	ADP
gs-3446	640	5	reduced	reduce	VERB
gs-3446	640	6	tissue	tissue	NOUN
gs-3446	640	7	regeneration	regeneration	NOUN
gs-3446	640	8	,	,	PUNCT
gs-3446	640	9	increased	increase	VERB
gs-3446	640	10	susceptibility	susceptibility	NOUN
gs-3446	640	11	to	to	ADP
gs-3446	640	12	degenerative	degenerative	ADJ
gs-3446	640	13	diseases	disease	NOUN
gs-3446	640	14	,	,	PUNCT
gs-3446	640	15	and	and	CCONJ
gs-3446	640	16	age	age	NOUN
gs-3446	640	17	-	-	PUNCT
gs-3446	640	18	related	relate	VERB
gs-3446	640	19	functional	functional	ADJ
gs-3446	640	20	decline	decline	NOUN
gs-3446	640	21	(	(	PUNCT
gs-3446	640	22	tkemaladze	tkemaladze	NOUN
gs-3446	640	23	,	,	PUNCT
gs-3446	640	24	2023	2023	NUM
gs-3446	640	25	)	)	PUNCT
gs-3446	640	26	.	.	PUNCT
gs-3446	641	1	understanding	understand	VERB
gs-3446	641	2	the	the	DET
gs-3446	641	3	mechanisms	mechanism	NOUN
gs-3446	641	4	underlying	underlie	VERB
gs-3446	641	5	this	this	DET
gs-3446	641	6	decline	decline	NOUN
gs-3446	641	7	is	be	AUX
gs-3446	641	8	critical	critical	ADJ
gs-3446	641	9	for	for	ADP
gs-3446	641	10	developing	develop	VERB
gs-3446	641	11	strategies	strategy	NOUN
gs-3446	641	12	to	to	PART
gs-3446	641	13	counteract	counteract	VERB
gs-3446	641	14	stem	stem	NOUN
gs-3446	641	15	cell	cell	NOUN
gs-3446	641	16	exhaustion	exhaustion	NOUN
gs-3446	641	17	and	and	CCONJ
gs-3446	641	18	enhance	enhance	VERB
gs-3446	641	19	therapeutic	therapeutic	ADJ
gs-3446	641	20	outcomes	outcome	NOUN
gs-3446	641	21	.	.	PUNCT
gs-3446	642	1	the	the	DET
gs-3446	642	2	decrease	decrease	NOUN
gs-3446	642	3	in	in	ADP
gs-3446	642	4	stem	stem	NOUN
gs-3446	642	5	cell	cell	NOUN
gs-3446	642	6	proliferative	proliferative	ADJ
gs-3446	642	7	capacity	capacity	NOUN
gs-3446	642	8	is	be	AUX
gs-3446	642	9	influenced	influence	VERB
gs-3446	642	10	by	by	ADP
gs-3446	642	11	intrinsic	intrinsic	ADJ
gs-3446	642	12	and	and	CCONJ
gs-3446	642	13	extrinsic	extrinsic	ADJ
gs-3446	642	14	factors	factor	NOUN
gs-3446	642	15	:	:	PUNCT
gs-3446	642	16	1	1	X
gs-3446	642	17	.	.	X
gs-3446	642	18	intrinsic	intrinsic	ADJ
gs-3446	642	19	mechanisms	mechanism	NOUN
gs-3446	642	20	○	○	X
gs-3446	642	21	centriolar	centriolar	ADJ
gs-3446	642	22	aging	aging	NOUN
gs-3446	642	23	:	:	PUNCT
gs-3446	642	24	accumulation	accumulation	NOUN
gs-3446	642	25	of	of	ADP
gs-3446	642	26	old	old	ADJ
gs-3446	642	27	centrioles	centriole	NOUN
gs-3446	642	28	in	in	ADP
gs-3446	642	29	stem	stem	NOUN
gs-3446	642	30	cells	cell	NOUN
gs-3446	642	31	disrupts	disrupt	VERB
gs-3446	642	32	mitotic	mitotic	ADJ
gs-3446	642	33	fidelity	fidelity	NOUN
gs-3446	642	34	,	,	PUNCT
gs-3446	642	35	leading	lead	VERB
gs-3446	642	36	to	to	ADP
gs-3446	642	37	asymmetric	asymmetric	ADJ
gs-3446	642	38	division	division	NOUN
gs-3446	642	39	defects	defect	NOUN
gs-3446	642	40	and	and	CCONJ
gs-3446	642	41	reduced	reduce	VERB
gs-3446	642	42	proliferative	proliferative	ADJ
gs-3446	642	43	potential	potential	NOUN
gs-3446	642	44	(	(	PUNCT
gs-3446	642	45	tkemaladze	tkemaladze	NOUN
gs-3446	642	46	,	,	PUNCT
gs-3446	642	47	2023	2023	NUM
gs-3446	642	48	;	;	PUNCT
gs-3446	642	49	tkemaladze	tkemaladze	NOUN
gs-3446	642	50	&	&	CCONJ
gs-3446	642	51	chichinadze	chichinadze	PROPN
gs-3446	642	52	,	,	PUNCT
gs-3446	642	53	2005	2005	NUM
gs-3446	642	54	)	)	PUNCT
gs-3446	642	55	.	.	PUNCT
gs-3446	643	1	○	○	ADJ
gs-3446	643	2	epigenetic	epigenetic	ADJ
gs-3446	643	3	alterations	alteration	NOUN
gs-3446	643	4	:	:	PUNCT
gs-3446	643	5	age	age	NOUN
gs-3446	643	6	-	-	PUNCT
gs-3446	643	7	associated	associate	VERB
gs-3446	643	8	changes	change	NOUN
gs-3446	643	9	in	in	ADP
gs-3446	643	10	dna	dna	PROPN
gs-3446	643	11	methylation	methylation	NOUN
gs-3446	643	12	and	and	CCONJ
gs-3446	643	13	histone	histone	NOUN
gs-3446	643	14	modifications	modification	NOUN
gs-3446	643	15	impair	impair	VERB
gs-3446	643	16	transcriptional	transcriptional	ADJ
gs-3446	643	17	networks	network	NOUN
gs-3446	643	18	essential	essential	ADJ
gs-3446	643	19	for	for	ADP
gs-3446	643	20	self	self	NOUN
gs-3446	643	21	-	-	PUNCT
gs-3446	643	22	renewal	renewal	NOUN
gs-3446	643	23	.	.	PUNCT
gs-3446	644	1	for	for	ADP
gs-3446	644	2	example	example	NOUN
gs-3446	644	3	,	,	PUNCT
gs-3446	644	4	dysregulation	dysregulation	NOUN
gs-3446	644	5	of	of	ADP
gs-3446	644	6	wnt	wnt	PROPN
gs-3446	644	7	/	/	SYM
gs-3446	644	8	β	β	NOUN
gs-3446	644	9	-	-	NOUN
gs-3446	644	10	catenin	catenin	ADJ
gs-3446	644	11	and	and	CCONJ
gs-3446	644	12	notch	notch	VERB
gs-3446	644	13	signaling	signal	VERB
gs-3446	644	14	pathways	pathway	NOUN
gs-3446	644	15	compromises	compromise	NOUN
gs-3446	644	16	stem	stem	NOUN
gs-3446	644	17	cell	cell	NOUN
gs-3446	644	18	quiescence	quiescence	NOUN
gs-3446	644	19	(	(	PUNCT
gs-3446	644	20	zhang	zhang	PROPN
gs-3446	644	21	et	et	PROPN
gs-3446	644	22	al	al	PROPN
gs-3446	644	23	.	.	PROPN
gs-3446	644	24	,	,	PUNCT
gs-3446	644	25	2022	2022	NUM
gs-3446	644	26	;	;	PUNCT
gs-3446	644	27	sharma	sharma	PROPN
gs-3446	644	28	et	et	PROPN
gs-3446	644	29	al	al	PROPN
gs-3446	644	30	.	.	PROPN
gs-3446	644	31	,	,	PUNCT
gs-3446	644	32	2021	2021	NUM
gs-3446	644	33	)	)	PUNCT
gs-3446	644	34	.	.	PUNCT
gs-3446	645	1	○	○	ADJ
gs-3446	645	2	oxidative	oxidative	ADJ
gs-3446	645	3	stress	stress	NOUN
gs-3446	645	4	and	and	CCONJ
gs-3446	645	5	dna	dna	NOUN
gs-3446	645	6	damage	damage	NOUN
gs-3446	645	7	:	:	PUNCT
gs-3446	645	8	reactive	reactive	ADJ
gs-3446	645	9	oxygen	oxygen	NOUN
gs-3446	645	10	species	specie	NOUN
gs-3446	645	11	(	(	PUNCT
gs-3446	645	12	ros	ros	PROPN
gs-3446	645	13	)	)	PUNCT
gs-3446	645	14	and	and	CCONJ
gs-3446	645	15	unresolved	unresolved	ADJ
gs-3446	645	16	dna	dna	PROPN
gs-3446	645	17	breaks	break	NOUN
gs-3446	645	18	activate	activate	VERB
gs-3446	645	19	senescence	senescence	NOUN
gs-3446	645	20	pathways	pathway	NOUN
gs-3446	645	21	,	,	PUNCT
gs-3446	645	22	halting	halting	ADJ
gs-3446	645	23	division	division	NOUN
gs-3446	645	24	(	(	PUNCT
gs-3446	645	25	lobo	lobo	PROPN
gs-3446	645	26	et	et	PROPN
gs-3446	645	27	al	al	PROPN
gs-3446	645	28	.	.	PROPN
gs-3446	645	29	,	,	PUNCT
gs-3446	645	30	2012	2012	NUM
gs-3446	645	31	;	;	PUNCT
gs-3446	645	32	van	van	PROPN
gs-3446	645	33	der	der	NOUN
gs-3446	645	34	flier	flier	NOUN
gs-3446	645	35	&	&	CCONJ
gs-3446	645	36	clevers	clever	NOUN
gs-3446	645	37	,	,	PUNCT
gs-3446	645	38	2009	2009	NUM
gs-3446	645	39	)	)	PUNCT
gs-3446	645	40	.	.	PUNCT
gs-3446	646	1	2	2	X
gs-3446	646	2	.	.	NUM
gs-3446	646	3	extrinsic	extrinsic	ADJ
gs-3446	646	4	mechanisms	mechanism	NOUN
gs-3446	646	5	○	○	ADJ
gs-3446	646	6	niche	niche	NOUN
gs-3446	646	7	degradation	degradation	NOUN
gs-3446	646	8	:	:	PUNCT
gs-3446	646	9	aging	aging	NOUN
gs-3446	646	10	disrupts	disrupt	VERB
gs-3446	646	11	the	the	DET
gs-3446	646	12	stem	stem	NOUN
gs-3446	646	13	cell	cell	NOUN
gs-3446	646	14	niche	niche	NOUN
gs-3446	646	15	,	,	PUNCT
gs-3446	646	16	reducing	reduce	VERB
gs-3446	646	17	supportive	supportive	ADJ
gs-3446	646	18	signals	signal	NOUN
gs-3446	646	19	such	such	ADJ
gs-3446	646	20	as	as	ADP
gs-3446	646	21	cxcl12	cxcl12	ADJ
gs-3446	646	22	and	and	CCONJ
gs-3446	646	23	scf	scf	PROPN
gs-3446	646	24	,	,	PUNCT
gs-3446	646	25	which	which	PRON
gs-3446	646	26	are	be	AUX
gs-3446	646	27	critical	critical	ADJ
gs-3446	646	28	for	for	ADP
gs-3446	646	29	hematopoietic	hematopoietic	ADJ
gs-3446	646	30	stem	stem	NOUN
gs-3446	646	31	cell	cell	NOUN
gs-3446	646	32	maintenance	maintenance	NOUN
gs-3446	646	33	(	(	PUNCT
gs-3446	646	34	tuan	tuan	PROPN
gs-3446	646	35	et	et	PROPN
gs-3446	646	36	al	al	PROPN
gs-3446	646	37	.	.	PROPN
gs-3446	646	38	,	,	PUNCT
gs-3446	646	39	2003	2003	NUM
gs-3446	646	40	)	)	PUNCT
gs-3446	646	41	.	.	PUNCT
gs-3446	647	1	○	○	ADJ
gs-3446	647	2	systemic	systemic	ADJ
gs-3446	647	3	inflammation	inflammation	NOUN
gs-3446	647	4	:	:	PUNCT
gs-3446	647	5	pro	pro	ADJ
gs-3446	647	6	-	-	ADJ
gs-3446	647	7	inflammatory	inflammatory	ADJ
gs-3446	647	8	cytokines	cytokine	NOUN
gs-3446	647	9	(	(	PUNCT
gs-3446	647	10	e.g.	e.g.	ADV
gs-3446	647	11	,	,	PUNCT
gs-3446	647	12	il-6	il-6	NUM
gs-3446	647	13	,	,	PUNCT
gs-3446	647	14	tnf	tnf	PROPN
gs-3446	647	15	-	-	PUNCT
gs-3446	647	16	α	α	NOUN
gs-3446	647	17	)	)	PUNCT
gs-3446	647	18	alter	alter	NOUN
gs-3446	647	19	stem	stem	NOUN
gs-3446	647	20	cell	cell	NOUN
gs-3446	647	21	behavior	behavior	NOUN
gs-3446	647	22	,	,	PUNCT
gs-3446	647	23	promoting	promote	VERB
gs-3446	647	24	differentiation	differentiation	NOUN
gs-3446	647	25	over	over	ADP
gs-3446	647	26	self	self	NOUN
gs-3446	647	27	-	-	PUNCT
gs-3446	647	28	renewal	renewal	NOUN
gs-3446	647	29	(	(	PUNCT
gs-3446	647	30	newmark	newmark	PROPN
gs-3446	647	31	et	et	PROPN
gs-3446	647	32	al	al	PROPN
gs-3446	647	33	.	.	PROPN
gs-3446	647	34	,	,	PUNCT
gs-3446	647	35	2008	2008	NUM
gs-3446	647	36	)	)	PUNCT
gs-3446	647	37	.	.	PUNCT
gs-3446	648	1	consequences	consequence	NOUN
gs-3446	648	2	of	of	ADP
gs-3446	648	3	reduced	reduced	ADJ
gs-3446	648	4	division	division	NOUN
gs-3446	648	5	rates	rate	NOUN
gs-3446	648	6	1	1	NUM
gs-3446	648	7	.	.	PUNCT
gs-3446	648	8	tissue	tissue	NOUN
gs-3446	648	9	atrophy	atrophy	NOUN
gs-3446	648	10	and	and	CCONJ
gs-3446	648	11	dysfunction	dysfunction	NOUN
gs-3446	648	12	:	:	PUNCT
gs-3446	648	13	declining	decline	VERB
gs-3446	648	14	division	division	NOUN
gs-3446	648	15	rates	rate	NOUN
gs-3446	648	16	impair	impair	VERB
gs-3446	648	17	the	the	DET
gs-3446	648	18	replenishment	replenishment	NOUN
gs-3446	648	19	of	of	ADP
gs-3446	648	20	differentiated	differentiated	ADJ
gs-3446	648	21	cells	cell	NOUN
gs-3446	648	22	,	,	PUNCT
gs-3446	648	23	leading	lead	VERB
gs-3446	648	24	to	to	ADP
gs-3446	648	25	conditions	condition	NOUN
gs-3446	648	26	such	such	ADJ
gs-3446	648	27	as	as	ADP
gs-3446	648	28	osteoporosis	osteoporosis	NOUN
gs-3446	648	29	,	,	PUNCT
gs-3446	648	30	sarcopenia	sarcopenia	NOUN
gs-3446	648	31	,	,	PUNCT
gs-3446	648	32	and	and	CCONJ
gs-3446	648	33	immune	immune	ADJ
gs-3446	648	34	senescence	senescence	NOUN
gs-3446	648	35	(	(	PUNCT
gs-3446	648	36	baguñà	baguñà	NOUN
gs-3446	648	37	et	et	PROPN
gs-3446	648	38	al	al	PROPN
gs-3446	648	39	.	.	PROPN
gs-3446	648	40	,	,	PUNCT
gs-3446	648	41	1990	1990	NUM
gs-3446	648	42	)	)	PUNCT
gs-3446	648	43	.	.	PUNCT
gs-3446	649	1	georgian	georgian	ADJ
gs-3446	649	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	649	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	649	4	ტ.	ტ.	VERB
gs-3446	649	5	7	7	NUM
gs-3446	649	6	n	n	DET
gs-3446	649	7	1	1	NUM
gs-3446	649	8	,	,	PUNCT
gs-3446	649	9	2025	2025	NUM
gs-3446	649	10	311	311	NUM
gs-3446	649	11	2	2	NUM
gs-3446	649	12	.	.	PUNCT
gs-3446	650	1	compromised	compromise	VERB
gs-3446	650	2	regeneration	regeneration	NOUN
gs-3446	650	3	:	:	PUNCT
gs-3446	650	4	reduced	reduce	VERB
gs-3446	650	5	proliferative	proliferative	ADJ
gs-3446	650	6	capacity	capacity	NOUN
gs-3446	650	7	limits	limit	VERB
gs-3446	650	8	tissue	tissue	NOUN
gs-3446	650	9	repair	repair	VERB
gs-3446	650	10	post	post	NOUN
gs-3446	650	11	-	-	NOUN
gs-3446	650	12	injury	injury	NOUN
gs-3446	650	13	.	.	PUNCT
gs-3446	651	1	for	for	ADP
gs-3446	651	2	instance	instance	NOUN
gs-3446	651	3	,	,	PUNCT
gs-3446	651	4	aged	aged	ADJ
gs-3446	651	5	neural	neural	ADJ
gs-3446	651	6	stem	stem	NOUN
gs-3446	651	7	cells	cell	NOUN
gs-3446	651	8	fail	fail	VERB
gs-3446	651	9	to	to	PART
gs-3446	651	10	generate	generate	VERB
gs-3446	651	11	sufficient	sufficient	ADJ
gs-3446	651	12	neurons	neuron	NOUN
gs-3446	651	13	after	after	ADP
gs-3446	651	14	brain	brain	NOUN
gs-3446	651	15	trauma	trauma	NOUN
gs-3446	651	16	(	(	PUNCT
gs-3446	651	17	gomes	gome	NOUN
gs-3446	651	18	et	et	PROPN
gs-3446	651	19	al	al	PROPN
gs-3446	651	20	.	.	PROPN
gs-3446	651	21	,	,	PUNCT
gs-3446	651	22	2011	2011	NUM
gs-3446	651	23	)	)	PUNCT
gs-3446	651	24	.	.	PUNCT
gs-3446	652	1	3	3	X
gs-3446	652	2	.	.	X
gs-3446	652	3	cancer	cancer	NOUN
gs-3446	652	4	risk	risk	NOUN
gs-3446	652	5	:	:	PUNCT
gs-3446	652	6	paradoxically	paradoxically	ADV
gs-3446	652	7	,	,	PUNCT
gs-3446	652	8	residual	residual	ADJ
gs-3446	652	9	stem	stem	NOUN
gs-3446	652	10	cells	cell	NOUN
gs-3446	652	11	with	with	ADP
gs-3446	652	12	accumulated	accumulate	VERB
gs-3446	652	13	mutations	mutation	NOUN
gs-3446	652	14	may	may	AUX
gs-3446	652	15	undergo	undergo	VERB
gs-3446	652	16	clonal	clonal	ADJ
gs-3446	652	17	expansion	expansion	NOUN
gs-3446	652	18	,	,	PUNCT
gs-3446	652	19	increasing	increase	VERB
gs-3446	652	20	malignancy	malignancy	NOUN
gs-3446	652	21	risk	risk	NOUN
gs-3446	652	22	(	(	PUNCT
gs-3446	652	23	swain	swain	PROPN
gs-3446	652	24	et	et	PROPN
gs-3446	652	25	al	al	PROPN
gs-3446	652	26	.	.	PROPN
gs-3446	652	27	,	,	PUNCT
gs-3446	652	28	2020	2020	NUM
gs-3446	652	29	)	)	PUNCT
gs-3446	652	30	.	.	PUNCT
gs-3446	653	1	current	current	ADJ
gs-3446	653	2	research	research	NOUN
gs-3446	653	3	and	and	CCONJ
gs-3446	653	4	interventions	intervention	NOUN
gs-3446	653	5	1	1	NUM
gs-3446	653	6	.	.	X
gs-3446	653	7	centriole	centriole	NOUN
gs-3446	653	8	-	-	PUNCT
gs-3446	653	9	targeted	target	VERB
gs-3446	653	10	approaches	approach	NOUN
gs-3446	653	11	:	:	PUNCT
gs-3446	653	12	tkemaladze	tkemaladze	NOUN
gs-3446	653	13	(	(	PUNCT
gs-3446	653	14	2023	2023	NUM
gs-3446	653	15	)	)	PUNCT
gs-3446	653	16	proposes	propose	VERB
gs-3446	653	17	that	that	SCONJ
gs-3446	653	18	selective	selective	ADJ
gs-3446	653	19	removal	removal	NOUN
gs-3446	653	20	of	of	ADP
gs-3446	653	21	aged	aged	ADJ
gs-3446	653	22	centrioles	centriole	NOUN
gs-3446	653	23	could	could	AUX
gs-3446	653	24	rejuvenate	rejuvenate	VERB
gs-3446	653	25	stem	stem	NOUN
gs-3446	653	26	cell	cell	NOUN
gs-3446	653	27	division	division	NOUN
gs-3446	653	28	,	,	PUNCT
gs-3446	653	29	though	though	SCONJ
gs-3446	653	30	this	this	PRON
gs-3446	653	31	remains	remain	VERB
gs-3446	653	32	experimental	experimental	ADJ
gs-3446	653	33	.	.	PUNCT
gs-3446	654	1	2	2	X
gs-3446	654	2	.	.	X
gs-3446	654	3	pharmacological	pharmacological	ADJ
gs-3446	654	4	interventions	intervention	NOUN
gs-3446	654	5	:	:	PUNCT
gs-3446	654	6	short	short	ADJ
gs-3446	654	7	-	-	PUNCT
gs-3446	654	8	term	term	NOUN
gs-3446	654	9	administration	administration	NOUN
gs-3446	654	10	of	of	ADP
gs-3446	654	11	dasatinib	dasatinib	NOUN
gs-3446	654	12	and	and	CCONJ
gs-3446	654	13	quercetin	quercetin	NOUN
gs-3446	654	14	,	,	PUNCT
gs-3446	654	15	senolytics	senolytic	NOUN
gs-3446	654	16	that	that	SCONJ
gs-3446	654	17	clear	clear	ADJ
gs-3446	654	18	senescent	senescent	ADJ
gs-3446	654	19	cells	cell	NOUN
gs-3446	654	20	,	,	PUNCT
gs-3446	654	21	has	have	AUX
gs-3446	654	22	shown	show	VERB
gs-3446	654	23	promise	promise	NOUN
gs-3446	654	24	in	in	ADP
gs-3446	654	25	improving	improve	VERB
gs-3446	654	26	stem	stem	NOUN
gs-3446	654	27	cell	cell	NOUN
gs-3446	654	28	function	function	NOUN
gs-3446	654	29	in	in	ADP
gs-3446	654	30	human	human	ADJ
gs-3446	654	31	trials	trial	NOUN
gs-3446	654	32	(	(	PUNCT
gs-3446	654	33	tkemaladze	tkemaladze	NOUN
gs-3446	654	34	&	&	CCONJ
gs-3446	654	35	apkhazava	apkhazava	PROPN
gs-3446	654	36	,	,	PUNCT
gs-3446	654	37	2019	2019	NUM
gs-3446	654	38	)	)	PUNCT
gs-3446	654	39	.	.	PUNCT
gs-3446	655	1	3	3	X
gs-3446	655	2	.	.	X
gs-3446	655	3	epigenetic	epigenetic	ADJ
gs-3446	655	4	reprogramming	reprogramming	NOUN
gs-3446	655	5	:	:	PUNCT
gs-3446	655	6	resetting	reset	VERB
gs-3446	655	7	dna	dna	PROPN
gs-3446	655	8	methylation	methylation	NOUN
gs-3446	655	9	patterns	pattern	NOUN
gs-3446	655	10	using	use	VERB
gs-3446	655	11	yamanaka	yamanaka	PROPN
gs-3446	655	12	factors	factor	NOUN
gs-3446	655	13	(	(	PUNCT
gs-3446	655	14	oct4	oct4	NOUN
gs-3446	655	15	,	,	PUNCT
gs-3446	655	16	sox2	sox2	NOUN
gs-3446	655	17	,	,	PUNCT
gs-3446	655	18	klf4	klf4	PROPN
gs-3446	655	19	)	)	PUNCT
gs-3446	655	20	restores	restore	VERB
gs-3446	655	21	pluripotency	pluripotency	NOUN
gs-3446	655	22	in	in	ADP
gs-3446	655	23	aged	aged	ADJ
gs-3446	655	24	cells	cell	NOUN
gs-3446	655	25	(	(	PUNCT
gs-3446	655	26	schmidt	schmidt	PROPN
gs-3446	655	27	&	&	CCONJ
gs-3446	655	28	plath	plath	NOUN
gs-3446	655	29	,	,	PUNCT
gs-3446	655	30	2012	2012	NUM
gs-3446	655	31	)	)	PUNCT
gs-3446	655	32	.	.	PUNCT
gs-3446	656	1	challenges	challenge	NOUN
gs-3446	656	2	and	and	CCONJ
gs-3446	656	3	future	future	ADJ
gs-3446	656	4	directions	direction	NOUN
gs-3446	656	5	1	1	NUM
gs-3446	656	6	.	.	PUNCT
gs-3446	656	7	tumorigenic	tumorigenic	ADJ
gs-3446	656	8	risks	risk	NOUN
gs-3446	656	9	:	:	PUNCT
gs-3446	656	10	reactivating	reactivate	VERB
gs-3446	656	11	division	division	NOUN
gs-3446	656	12	in	in	ADP
gs-3446	656	13	aged	aged	ADJ
gs-3446	656	14	stem	stem	NOUN
gs-3446	656	15	cells	cell	NOUN
gs-3446	656	16	may	may	AUX
gs-3446	656	17	inadvertently	inadvertently	ADV
gs-3446	656	18	promote	promote	VERB
gs-3446	656	19	cancer	cancer	NOUN
gs-3446	656	20	(	(	PUNCT
gs-3446	656	21	swain	swain	PROPN
gs-3446	656	22	et	et	PROPN
gs-3446	656	23	al	al	PROPN
gs-3446	656	24	.	.	PROPN
gs-3446	656	25	,	,	PUNCT
gs-3446	656	26	2020	2020	NUM
gs-3446	656	27	)	)	PUNCT
gs-3446	656	28	.	.	PUNCT
gs-3446	657	1	2	2	X
gs-3446	657	2	.	.	X
gs-3446	657	3	niche	niche	NOUN
gs-3446	657	4	engineering	engineering	NOUN
gs-3446	657	5	:	:	PUNCT
gs-3446	657	6	developing	develop	VERB
gs-3446	657	7	artificial	artificial	ADJ
gs-3446	657	8	niches	niche	NOUN
gs-3446	657	9	with	with	ADP
gs-3446	657	10	biomaterials	biomaterial	NOUN
gs-3446	657	11	to	to	PART
gs-3446	657	12	mimic	mimic	VERB
gs-3446	657	13	youthful	youthful	ADJ
gs-3446	657	14	microenvironments	microenvironment	NOUN
gs-3446	657	15	could	could	AUX
gs-3446	657	16	sustain	sustain	VERB
gs-3446	657	17	stem	stem	NOUN
gs-3446	657	18	cell	cell	NOUN
gs-3446	657	19	proliferation	proliferation	NOUN
gs-3446	657	20	(	(	PUNCT
gs-3446	657	21	park	park	NOUN
gs-3446	657	22	et	et	PROPN
gs-3446	657	23	al	al	PROPN
gs-3446	657	24	.	.	PROPN
gs-3446	657	25	,	,	PUNCT
gs-3446	657	26	2015	2015	NUM
gs-3446	657	27	)	)	PUNCT
gs-3446	657	28	.	.	PUNCT
gs-3446	658	1	3	3	X
gs-3446	658	2	.	.	X
gs-3446	658	3	personalized	personalized	ADJ
gs-3446	658	4	therapies	therapy	NOUN
gs-3446	658	5	:	:	PUNCT
gs-3446	658	6	integrating	integrate	VERB
gs-3446	658	7	crispr	crispr	NOUN
gs-3446	658	8	-	-	PUNCT
gs-3446	658	9	based	base	VERB
gs-3446	658	10	gene	gene	NOUN
gs-3446	658	11	editing	edit	VERB
gs-3446	658	12	to	to	PART
gs-3446	658	13	correct	correct	VERB
gs-3446	658	14	age	age	NOUN
gs-3446	658	15	-	-	PUNCT
gs-3446	658	16	related	relate	VERB
gs-3446	658	17	mutations	mutation	NOUN
gs-3446	658	18	in	in	ADP
gs-3446	658	19	patient	patient	NOUN
gs-3446	658	20	-	-	PUNCT
gs-3446	658	21	specific	specific	ADJ
gs-3446	658	22	ipscs	ipscs	NOUN
gs-3446	658	23	offers	offer	VERB
gs-3446	658	24	tailored	tailor	VERB
gs-3446	658	25	solutions	solution	NOUN
gs-3446	658	26	(	(	PUNCT
gs-3446	658	27	burnight	burnight	VERB
gs-3446	658	28	et	et	PROPN
gs-3446	658	29	al	al	PROPN
gs-3446	658	30	.	.	PROPN
gs-3446	658	31	,	,	PUNCT
gs-3446	658	32	2015	2015	NUM
gs-3446	658	33	)	)	PUNCT
gs-3446	658	34	.	.	PUNCT
gs-3446	659	1	the	the	DET
gs-3446	659	2	decline	decline	NOUN
gs-3446	659	3	in	in	ADP
gs-3446	659	4	stem	stem	NOUN
gs-3446	659	5	cell	cell	NOUN
gs-3446	659	6	division	division	NOUN
gs-3446	659	7	rates	rate	NOUN
gs-3446	659	8	over	over	ADP
gs-3446	659	9	time	time	NOUN
gs-3446	659	10	poses	pose	VERB
gs-3446	659	11	a	a	DET
gs-3446	659	12	significant	significant	ADJ
gs-3446	659	13	barrier	barrier	NOUN
gs-3446	659	14	to	to	ADP
gs-3446	659	15	tissue	tissue	NOUN
gs-3446	659	16	homeostasis	homeostasis	NOUN
gs-3446	659	17	and	and	CCONJ
gs-3446	659	18	regeneration	regeneration	NOUN
gs-3446	659	19	.	.	PUNCT
gs-3446	660	1	while	while	SCONJ
gs-3446	660	2	intrinsic	intrinsic	ADJ
gs-3446	660	3	factors	factor	NOUN
gs-3446	660	4	like	like	ADP
gs-3446	660	5	centriolar	centriolar	ADJ
gs-3446	660	6	aging	aging	NOUN
gs-3446	660	7	and	and	CCONJ
gs-3446	660	8	epigenetic	epigenetic	ADJ
gs-3446	660	9	drift	drift	NOUN
gs-3446	660	10	play	play	VERB
gs-3446	660	11	central	central	ADJ
gs-3446	660	12	roles	role	NOUN
gs-3446	660	13	,	,	PUNCT
gs-3446	660	14	extrinsic	extrinsic	ADJ
gs-3446	660	15	niche	niche	NOUN
gs-3446	660	16	degradation	degradation	NOUN
gs-3446	660	17	and	and	CCONJ
gs-3446	660	18	systemic	systemic	ADJ
gs-3446	660	19	inflammation	inflammation	NOUN
gs-3446	660	20	exacerbate	exacerbate	VERB
gs-3446	660	21	the	the	DET
gs-3446	660	22	problem	problem	NOUN
gs-3446	660	23	.	.	PUNCT
gs-3446	661	1	emerging	emerge	VERB
gs-3446	661	2	strategies	strategy	NOUN
gs-3446	661	3	,	,	PUNCT
gs-3446	661	4	including	include	VERB
gs-3446	661	5	replacement	replacement	NOUN
gs-3446	661	6	of	of	ADP
gs-3446	661	7	old	old	ADJ
gs-3446	661	8	centrioles	centriole	NOUN
gs-3446	661	9	with	with	ADP
gs-3446	661	10	young	young	ADJ
gs-3446	661	11	ones	one	NOUN
gs-3446	661	12	,	,	PUNCT
gs-3446	661	13	senolytics	senolytic	NOUN
gs-3446	661	14	,	,	PUNCT
gs-3446	661	15	and	and	CCONJ
gs-3446	661	16	epigenetic	epigenetic	ADJ
gs-3446	661	17	reprogramming	reprogramming	NOUN
gs-3446	661	18	,	,	PUNCT
gs-3446	661	19	hold	hold	VERB
gs-3446	661	20	potential	potential	ADJ
gs-3446	661	21	but	but	CCONJ
gs-3446	661	22	require	require	VERB
gs-3446	661	23	rigorous	rigorous	ADJ
gs-3446	661	24	validation	validation	NOUN
gs-3446	661	25	.	.	PUNCT
gs-3446	662	1	addressing	address	VERB
gs-3446	662	2	these	these	DET
gs-3446	662	3	challenges	challenge	NOUN
gs-3446	662	4	will	will	AUX
gs-3446	662	5	be	be	AUX
gs-3446	662	6	pivotal	pivotal	ADJ
gs-3446	662	7	for	for	ADP
gs-3446	662	8	advancing	advance	VERB
gs-3446	662	9	regenerative	regenerative	ADJ
gs-3446	662	10	medicine	medicine	NOUN
gs-3446	662	11	and	and	CCONJ
gs-3446	662	12	mitigating	mitigate	VERB
gs-3446	662	13	age	age	NOUN
gs-3446	662	14	-	-	PUNCT
gs-3446	662	15	related	relate	VERB
gs-3446	662	16	degeneration	degeneration	NOUN
gs-3446	662	17	.	.	PUNCT
gs-3446	663	1	discussion	discussion	NOUN
gs-3446	663	2	the	the	DET
gs-3446	663	3	study	study	NOUN
gs-3446	663	4	of	of	ADP
gs-3446	663	5	stem	stem	NOUN
gs-3446	663	6	cell	cell	NOUN
gs-3446	663	7	systems	system	NOUN
gs-3446	663	8	and	and	CCONJ
gs-3446	663	9	their	their	PRON
gs-3446	663	10	regenerative	regenerative	ADJ
gs-3446	663	11	potential	potential	NOUN
gs-3446	663	12	has	have	AUX
gs-3446	663	13	revolutionized	revolutionize	VERB
gs-3446	663	14	our	our	PRON
gs-3446	663	15	understanding	understanding	NOUN
gs-3446	663	16	of	of	ADP
gs-3446	663	17	biology	biology	NOUN
gs-3446	663	18	and	and	CCONJ
gs-3446	663	19	medicine	medicine	NOUN
gs-3446	663	20	.	.	PUNCT
gs-3446	664	1	stem	stem	NOUN
gs-3446	664	2	cells	cell	NOUN
gs-3446	664	3	,	,	PUNCT
gs-3446	664	4	with	with	ADP
gs-3446	664	5	their	their	PRON
gs-3446	664	6	unique	unique	ADJ
gs-3446	664	7	ability	ability	NOUN
gs-3446	664	8	to	to	PART
gs-3446	664	9	self	self	NOUN
gs-3446	664	10	-	-	PUNCT
gs-3446	664	11	renew	renew	NOUN
gs-3446	664	12	and	and	CCONJ
gs-3446	664	13	differentiate	differentiate	VERB
gs-3446	664	14	,	,	PUNCT
gs-3446	664	15	hold	hold	VERB
gs-3446	664	16	immense	immense	ADJ
gs-3446	664	17	promise	promise	NOUN
gs-3446	664	18	for	for	ADP
gs-3446	664	19	treating	treat	VERB
gs-3446	664	20	degenerative	degenerative	ADJ
gs-3446	664	21	diseases	disease	NOUN
gs-3446	664	22	,	,	PUNCT
gs-3446	664	23	injuries	injury	NOUN
gs-3446	664	24	,	,	PUNCT
gs-3446	664	25	and	and	CCONJ
gs-3446	664	26	aging	age	VERB
gs-3446	664	27	-	-	PUNCT
gs-3446	664	28	related	relate	VERB
gs-3446	664	29	conditions	condition	NOUN
gs-3446	664	30	.	.	PUNCT
gs-3446	665	1	however	however	ADV
gs-3446	665	2	,	,	PUNCT
gs-3446	665	3	significant	significant	ADJ
gs-3446	665	4	challenges	challenge	NOUN
gs-3446	665	5	remain	remain	VERB
gs-3446	665	6	in	in	ADP
gs-3446	665	7	translating	translate	VERB
gs-3446	665	8	stem	stem	NOUN
gs-3446	665	9	cell	cell	NOUN
gs-3446	665	10	research	research	NOUN
gs-3446	665	11	into	into	ADP
gs-3446	665	12	clinical	clinical	ADJ
gs-3446	665	13	applications	application	NOUN
gs-3446	665	14	.	.	PUNCT
gs-3446	666	1	this	this	DET
gs-3446	666	2	discussion	discussion	NOUN
gs-3446	666	3	highlights	highlight	VERB
gs-3446	666	4	key	key	ADJ
gs-3446	666	5	insights	insight	NOUN
gs-3446	666	6	,	,	PUNCT
gs-3446	666	7	challenges	challenge	NOUN
gs-3446	666	8	,	,	PUNCT
gs-3446	666	9	and	and	CCONJ
gs-3446	666	10	future	future	ADJ
gs-3446	666	11	directions	direction	NOUN
gs-3446	666	12	in	in	ADP
gs-3446	666	13	stem	stem	NOUN
gs-3446	666	14	cell	cell	NOUN
gs-3446	666	15	research	research	NOUN
gs-3446	666	16	,	,	PUNCT
gs-3446	666	17	emphasizing	emphasize	VERB
gs-3446	666	18	the	the	DET
gs-3446	666	19	need	need	NOUN
gs-3446	666	20	for	for	ADP
gs-3446	666	21	interdisciplinary	interdisciplinary	ADJ
gs-3446	666	22	collaboration	collaboration	NOUN
gs-3446	666	23	and	and	CCONJ
gs-3446	666	24	ethical	ethical	ADJ
gs-3446	666	25	considerations	consideration	NOUN
gs-3446	666	26	.	.	PUNCT
gs-3446	667	1	georgian	georgian	ADJ
gs-3446	667	2	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3446	667	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	667	4	ტ.	ტ.	VERB
gs-3446	667	5	7	7	NUM
gs-3446	667	6	n	n	DET
gs-3446	667	7	1	1	NUM
gs-3446	667	8	,	,	PUNCT
gs-3446	667	9	2025	2025	NUM
gs-3446	667	10	312	312	NUM
gs-3446	667	11	key	key	ADJ
gs-3446	667	12	insights	insight	NOUN
gs-3446	667	13	1	1	NUM
gs-3446	667	14	.	.	PUNCT
gs-3446	667	15	heterogeneity	heterogeneity	NOUN
gs-3446	667	16	and	and	CCONJ
gs-3446	667	17	plasticity	plasticity	NOUN
gs-3446	667	18	:	:	PUNCT
gs-3446	667	19	stem	stem	NOUN
gs-3446	667	20	cell	cell	NOUN
gs-3446	667	21	populations	population	NOUN
gs-3446	667	22	are	be	AUX
gs-3446	667	23	highly	highly	ADV
gs-3446	667	24	heterogeneous	heterogeneous	ADJ
gs-3446	667	25	,	,	PUNCT
gs-3446	667	26	with	with	ADP
gs-3446	667	27	varying	vary	VERB
gs-3446	667	28	degrees	degree	NOUN
gs-3446	667	29	of	of	ADP
gs-3446	667	30	potency	potency	NOUN
gs-3446	667	31	and	and	CCONJ
gs-3446	667	32	differentiation	differentiation	NOUN
gs-3446	667	33	potential	potential	NOUN
gs-3446	667	34	.	.	PUNCT
gs-3446	668	1	this	this	DET
gs-3446	668	2	heterogeneity	heterogeneity	NOUN
gs-3446	668	3	is	be	AUX
gs-3446	668	4	regulated	regulate	VERB
gs-3446	668	5	by	by	ADP
gs-3446	668	6	complex	complex	ADJ
gs-3446	668	7	transcriptional	transcriptional	ADJ
gs-3446	668	8	networks	network	NOUN
gs-3446	668	9	and	and	CCONJ
gs-3446	668	10	signaling	signal	VERB
gs-3446	668	11	pathways	pathway	NOUN
gs-3446	668	12	,	,	PUNCT
gs-3446	668	13	which	which	PRON
gs-3446	668	14	influence	influence	NOUN
gs-3446	668	15	cell	cell	NOUN
gs-3446	668	16	fate	fate	NOUN
gs-3446	668	17	decisions	decision	NOUN
gs-3446	668	18	.	.	PUNCT
gs-3446	669	1	understanding	understand	VERB
gs-3446	669	2	this	this	DET
gs-3446	669	3	plasticity	plasticity	NOUN
gs-3446	669	4	is	be	AUX
gs-3446	669	5	crucial	crucial	ADJ
gs-3446	669	6	for	for	ADP
gs-3446	669	7	optimizing	optimize	VERB
gs-3446	669	8	stem	stem	NOUN
gs-3446	669	9	cell	cell	NOUN
gs-3446	669	10	-	-	PUNCT
gs-3446	669	11	based	base	VERB
gs-3446	669	12	therapies	therapy	NOUN
gs-3446	669	13	.	.	PUNCT
gs-3446	670	1	for	for	ADP
gs-3446	670	2	example	example	NOUN
gs-3446	670	3	,	,	PUNCT
gs-3446	670	4	single	single	ADJ
gs-3446	670	5	-	-	PUNCT
gs-3446	670	6	cell	cell	NOUN
gs-3446	670	7	rna	rna	NOUN
gs-3446	670	8	sequencing	sequencing	NOUN
gs-3446	670	9	has	have	AUX
gs-3446	670	10	revealed	reveal	VERB
gs-3446	670	11	subpopulations	subpopulation	NOUN
gs-3446	670	12	within	within	ADP
gs-3446	670	13	pluripotent	pluripotent	ADJ
gs-3446	670	14	stem	stem	NOUN
gs-3446	670	15	cell	cell	NOUN
gs-3446	670	16	cultures	culture	NOUN
gs-3446	670	17	with	with	ADP
gs-3446	670	18	distinct	distinct	ADJ
gs-3446	670	19	transcriptional	transcriptional	ADJ
gs-3446	670	20	signatures	signature	NOUN
gs-3446	670	21	,	,	PUNCT
gs-3446	670	22	indicating	indicate	VERB
gs-3446	670	23	a	a	DET
gs-3446	670	24	spectrum	spectrum	NOUN
gs-3446	670	25	of	of	ADP
gs-3446	670	26	pluripotency	pluripotency	ADJ
gs-3446	670	27	states	state	NOUN
gs-3446	670	28	that	that	PRON
gs-3446	670	29	may	may	AUX
gs-3446	670	30	affect	affect	VERB
gs-3446	670	31	differentiation	differentiation	NOUN
gs-3446	670	32	efficiency	efficiency	NOUN
gs-3446	670	33	.	.	PUNCT
gs-3446	671	1	2	2	X
gs-3446	671	2	.	.	X
gs-3446	671	3	stem	stem	NOUN
gs-3446	671	4	cell	cell	NOUN
gs-3446	671	5	niches	niche	NOUN
gs-3446	671	6	:	:	PUNCT
gs-3446	671	7	the	the	DET
gs-3446	671	8	stem	stem	NOUN
gs-3446	671	9	cell	cell	NOUN
gs-3446	671	10	niche	niche	NOUN
gs-3446	671	11	plays	play	VERB
gs-3446	671	12	a	a	DET
gs-3446	671	13	critical	critical	ADJ
gs-3446	671	14	role	role	NOUN
gs-3446	671	15	in	in	ADP
gs-3446	671	16	maintaining	maintain	VERB
gs-3446	671	17	stem	stem	NOUN
gs-3446	671	18	cell	cell	NOUN
gs-3446	671	19	homeostasis	homeostasis	NOUN
gs-3446	671	20	by	by	ADP
gs-3446	671	21	providing	provide	VERB
gs-3446	671	22	biochemical	biochemical	ADJ
gs-3446	671	23	and	and	CCONJ
gs-3446	671	24	physical	physical	ADJ
gs-3446	671	25	cues	cue	NOUN
gs-3446	671	26	that	that	PRON
gs-3446	671	27	regulate	regulate	VERB
gs-3446	671	28	self	self	NOUN
gs-3446	671	29	-	-	PUNCT
gs-3446	671	30	renewal	renewal	NOUN
gs-3446	671	31	and	and	CCONJ
gs-3446	671	32	differentiation	differentiation	NOUN
gs-3446	671	33	.	.	PUNCT
gs-3446	672	1	disruptions	disruption	NOUN
gs-3446	672	2	in	in	ADP
gs-3446	672	3	the	the	DET
gs-3446	672	4	niche	niche	NOUN
gs-3446	672	5	can	can	AUX
gs-3446	672	6	lead	lead	VERB
gs-3446	672	7	to	to	PART
gs-3446	672	8	stem	stem	NOUN
gs-3446	672	9	cell	cell	NOUN
gs-3446	672	10	exhaustion	exhaustion	NOUN
gs-3446	672	11	or	or	CCONJ
gs-3446	672	12	uncontrolled	uncontrolled	ADJ
gs-3446	672	13	proliferation	proliferation	NOUN
gs-3446	672	14	,	,	PUNCT
gs-3446	672	15	contributing	contribute	VERB
gs-3446	672	16	to	to	ADP
gs-3446	672	17	aging	aging	NOUN
gs-3446	672	18	and	and	CCONJ
gs-3446	672	19	cancer	cancer	NOUN
gs-3446	672	20	.	.	PUNCT
gs-3446	673	1	for	for	ADP
gs-3446	673	2	instance	instance	NOUN
gs-3446	673	3	,	,	PUNCT
gs-3446	673	4	the	the	DET
gs-3446	673	5	bone	bone	NOUN
gs-3446	673	6	marrow	marrow	NOUN
gs-3446	673	7	niche	niche	NOUN
gs-3446	673	8	supports	support	VERB
gs-3446	673	9	hematopoietic	hematopoietic	ADJ
gs-3446	673	10	stem	stem	NOUN
gs-3446	673	11	cells	cell	NOUN
gs-3446	673	12	through	through	ADP
gs-3446	673	13	signals	signal	NOUN
gs-3446	673	14	like	like	ADP
gs-3446	673	15	cxcl12	cxcl12	NOUN
gs-3446	673	16	and	and	CCONJ
gs-3446	673	17	scf	scf	PROPN
gs-3446	673	18	,	,	PUNCT
gs-3446	673	19	while	while	SCONJ
gs-3446	673	20	the	the	DET
gs-3446	673	21	neural	neural	ADJ
gs-3446	673	22	stem	stem	NOUN
gs-3446	673	23	cell	cell	NOUN
gs-3446	673	24	niche	niche	NOUN
gs-3446	673	25	in	in	ADP
gs-3446	673	26	the	the	DET
gs-3446	673	27	brain	brain	NOUN
gs-3446	673	28	relies	rely	VERB
gs-3446	673	29	on	on	ADP
gs-3446	673	30	notch	notch	ADJ
gs-3446	673	31	and	and	CCONJ
gs-3446	673	32	bmp	bmp	NOUN
gs-3446	673	33	signaling	signaling	NOUN
gs-3446	673	34	.	.	PUNCT
gs-3446	674	1	3	3	X
gs-3446	674	2	.	.	X
gs-3446	674	3	aging	age	VERB
gs-3446	674	4	and	and	CCONJ
gs-3446	674	5	stem	stem	NOUN
gs-3446	674	6	cell	cell	NOUN
gs-3446	674	7	decline	decline	NOUN
gs-3446	674	8	:	:	PUNCT
gs-3446	674	9	aging	aging	NOUN
gs-3446	674	10	is	be	AUX
gs-3446	674	11	associated	associate	VERB
gs-3446	674	12	with	with	ADP
gs-3446	674	13	a	a	DET
gs-3446	674	14	decline	decline	NOUN
gs-3446	674	15	in	in	ADP
gs-3446	674	16	stem	stem	NOUN
gs-3446	674	17	cell	cell	NOUN
gs-3446	674	18	function	function	NOUN
gs-3446	674	19	,	,	PUNCT
gs-3446	674	20	driven	drive	VERB
gs-3446	674	21	by	by	ADP
gs-3446	674	22	intrinsic	intrinsic	ADJ
gs-3446	674	23	factors	factor	NOUN
gs-3446	674	24	(	(	PUNCT
gs-3446	674	25	e.g.	e.g.	ADV
gs-3446	674	26	,	,	PUNCT
gs-3446	674	27	dna	dna	NOUN
gs-3446	674	28	damage	damage	NOUN
gs-3446	674	29	,	,	PUNCT
gs-3446	674	30	epigenetic	epigenetic	ADJ
gs-3446	674	31	alterations	alteration	NOUN
gs-3446	674	32	)	)	PUNCT
gs-3446	674	33	and	and	CCONJ
gs-3446	674	34	extrinsic	extrinsic	ADJ
gs-3446	674	35	factors	factor	NOUN
gs-3446	674	36	(	(	PUNCT
gs-3446	674	37	e.g.	e.g.	ADV
gs-3446	674	38	,	,	PUNCT
gs-3446	674	39	niche	niche	NOUN
gs-3446	674	40	degradation	degradation	NOUN
gs-3446	674	41	,	,	PUNCT
gs-3446	674	42	inflammation	inflammation	NOUN
gs-3446	674	43	)	)	PUNCT
gs-3446	674	44	.	.	PUNCT
gs-3446	675	1	strategies	strategy	NOUN
gs-3446	675	2	to	to	PART
gs-3446	675	3	rejuvenate	rejuvenate	VERB
gs-3446	675	4	aged	aged	ADJ
gs-3446	675	5	stem	stem	NOUN
gs-3446	675	6	cells	cell	NOUN
gs-3446	675	7	,	,	PUNCT
gs-3446	675	8	such	such	ADJ
gs-3446	675	9	as	as	ADP
gs-3446	675	10	epigenetic	epigenetic	ADJ
gs-3446	675	11	reprogramming	reprogramming	NOUN
gs-3446	675	12	and	and	CCONJ
gs-3446	675	13	senolytic	senolytic	ADJ
gs-3446	675	14	therapies	therapy	NOUN
gs-3446	675	15	,	,	PUNCT
gs-3446	675	16	are	be	AUX
gs-3446	675	17	being	be	AUX
gs-3446	675	18	explored	explore	VERB
gs-3446	675	19	to	to	PART
gs-3446	675	20	counteract	counteract	VERB
gs-3446	675	21	age	age	NOUN
gs-3446	675	22	-	-	PUNCT
gs-3446	675	23	related	relate	VERB
gs-3446	675	24	degeneration	degeneration	NOUN
gs-3446	675	25	.	.	PUNCT
gs-3446	676	1	for	for	ADP
gs-3446	676	2	example	example	NOUN
gs-3446	676	3	,	,	PUNCT
gs-3446	676	4	short	short	ADJ
gs-3446	676	5	-	-	PUNCT
gs-3446	676	6	term	term	NOUN
gs-3446	676	7	administration	administration	NOUN
gs-3446	676	8	of	of	ADP
gs-3446	676	9	dasatinib	dasatinib	NOUN
gs-3446	676	10	and	and	CCONJ
gs-3446	676	11	quercetin	quercetin	NOUN
gs-3446	676	12	has	have	AUX
gs-3446	676	13	shown	show	VERB
gs-3446	676	14	promise	promise	NOUN
gs-3446	676	15	in	in	ADP
gs-3446	676	16	improving	improve	VERB
gs-3446	676	17	stem	stem	NOUN
gs-3446	676	18	cell	cell	NOUN
gs-3446	676	19	function	function	NOUN
gs-3446	676	20	in	in	ADP
gs-3446	676	21	human	human	ADJ
gs-3446	676	22	trials	trial	NOUN
gs-3446	676	23	.	.	PUNCT
gs-3446	677	1	4	4	X
gs-3446	677	2	.	.	X
gs-3446	677	3	cancer	cancer	NOUN
gs-3446	677	4	stem	stem	NOUN
gs-3446	677	5	cells	cell	NOUN
gs-3446	677	6	:	:	PUNCT
gs-3446	677	7	cancer	cancer	NOUN
gs-3446	677	8	stem	stem	NOUN
gs-3446	677	9	cells	cell	NOUN
gs-3446	677	10	(	(	PUNCT
gs-3446	677	11	cscs	cscs	PROPN
gs-3446	677	12	)	)	PUNCT
gs-3446	677	13	are	be	AUX
gs-3446	677	14	a	a	DET
gs-3446	677	15	subset	subset	NOUN
gs-3446	677	16	of	of	ADP
gs-3446	677	17	tumor	tumor	NOUN
gs-3446	677	18	cells	cell	NOUN
gs-3446	677	19	with	with	ADP
gs-3446	677	20	stem	stem	NOUN
gs-3446	677	21	-	-	PUNCT
gs-3446	677	22	like	like	ADJ
gs-3446	677	23	properties	property	NOUN
gs-3446	677	24	that	that	PRON
gs-3446	677	25	drive	drive	VERB
gs-3446	677	26	tumor	tumor	NOUN
gs-3446	677	27	initiation	initiation	NOUN
gs-3446	677	28	,	,	PUNCT
gs-3446	677	29	progression	progression	NOUN
gs-3446	677	30	,	,	PUNCT
gs-3446	677	31	and	and	CCONJ
gs-3446	677	32	therapy	therapy	NOUN
gs-3446	677	33	resistance	resistance	NOUN
gs-3446	677	34	.	.	PUNCT
gs-3446	678	1	targeting	target	VERB
gs-3446	678	2	cscs	cscs	PROPN
gs-3446	678	3	through	through	ADP
gs-3446	678	4	signaling	signal	VERB
gs-3446	678	5	pathway	pathway	NOUN
gs-3446	678	6	inhibitors	inhibitor	NOUN
gs-3446	678	7	(	(	PUNCT
gs-3446	678	8	e.g.	e.g.	ADV
gs-3446	678	9	,	,	PUNCT
gs-3446	678	10	wnt	wnt	NOUN
gs-3446	678	11	,	,	PUNCT
gs-3446	678	12	notch	notch	NOUN
gs-3446	678	13	)	)	PUNCT
gs-3446	678	14	and	and	CCONJ
gs-3446	678	15	immune	immune	NOUN
gs-3446	678	16	-	-	PUNCT
gs-3446	678	17	based	base	VERB
gs-3446	678	18	therapies	therapy	NOUN
gs-3446	678	19	offers	offer	VERB
gs-3446	678	20	a	a	DET
gs-3446	678	21	promising	promising	ADJ
gs-3446	678	22	approach	approach	NOUN
gs-3446	678	23	to	to	ADP
gs-3446	678	24	cancer	cancer	NOUN
gs-3446	678	25	treatment	treatment	NOUN
gs-3446	678	26	.	.	PUNCT
gs-3446	679	1	for	for	ADP
gs-3446	679	2	instance	instance	NOUN
gs-3446	679	3	,	,	PUNCT
gs-3446	679	4	aberrant	aberrant	ADJ
gs-3446	679	5	activation	activation	NOUN
gs-3446	679	6	of	of	ADP
gs-3446	679	7	wnt	wnt	NOUN
gs-3446	679	8	signaling	signal	VERB
gs-3446	679	9	in	in	ADP
gs-3446	679	10	colorectal	colorectal	ADJ
gs-3446	679	11	cancer	cancer	NOUN
gs-3446	679	12	stem	stem	NOUN
gs-3446	679	13	cells	cell	NOUN
gs-3446	679	14	contributes	contribute	VERB
gs-3446	679	15	to	to	ADP
gs-3446	679	16	tumor	tumor	NOUN
gs-3446	679	17	growth	growth	NOUN
gs-3446	679	18	and	and	CCONJ
gs-3446	679	19	therapy	therapy	NOUN
gs-3446	679	20	resistance	resistance	NOUN
gs-3446	679	21	(	(	PUNCT
gs-3446	679	22	aphkhazava	aphkhazava	NOUN
gs-3446	679	23	et	et	PROPN
gs-3446	679	24	al	al	PROPN
gs-3446	679	25	.	.	PROPN
gs-3446	679	26	2024	2024	NUM
gs-3446	679	27	)	)	PUNCT
gs-3446	679	28	.	.	PUNCT
gs-3446	680	1	5	5	X
gs-3446	680	2	.	.	X
gs-3446	680	3	ethical	ethical	ADJ
gs-3446	680	4	and	and	CCONJ
gs-3446	680	5	safety	safety	NOUN
gs-3446	680	6	considerations	consideration	NOUN
gs-3446	680	7	:	:	PUNCT
gs-3446	680	8	the	the	DET
gs-3446	680	9	use	use	NOUN
gs-3446	680	10	of	of	ADP
gs-3446	680	11	embryonic	embryonic	ADJ
gs-3446	680	12	stem	stem	NOUN
gs-3446	680	13	cells	cell	NOUN
gs-3446	680	14	(	(	PUNCT
gs-3446	680	15	escs	esc	NOUN
gs-3446	680	16	)	)	PUNCT
gs-3446	680	17	raises	raise	VERB
gs-3446	680	18	ethical	ethical	ADJ
gs-3446	680	19	concerns	concern	NOUN
gs-3446	680	20	,	,	PUNCT
gs-3446	680	21	while	while	SCONJ
gs-3446	680	22	ipscs	ipsc	NOUN
gs-3446	680	23	offer	offer	VERB
gs-3446	680	24	a	a	DET
gs-3446	680	25	viable	viable	ADJ
gs-3446	680	26	alternative	alternative	NOUN
gs-3446	680	27	for	for	ADP
gs-3446	680	28	personalized	personalized	ADJ
gs-3446	680	29	medicine	medicine	NOUN
gs-3446	680	30	.	.	PUNCT
gs-3446	681	1	however	however	ADV
gs-3446	681	2	,	,	PUNCT
gs-3446	681	3	challenges	challenge	NOUN
gs-3446	681	4	such	such	ADJ
gs-3446	681	5	as	as	ADP
gs-3446	681	6	tumorigenicity	tumorigenicity	NOUN
gs-3446	681	7	,	,	PUNCT
gs-3446	681	8	immune	immune	ADJ
gs-3446	681	9	rejection	rejection	NOUN
gs-3446	681	10	,	,	PUNCT
gs-3446	681	11	and	and	CCONJ
gs-3446	681	12	long	long	ADJ
gs-3446	681	13	-	-	PUNCT
gs-3446	681	14	term	term	NOUN
gs-3446	681	15	integration	integration	NOUN
gs-3446	681	16	must	must	AUX
gs-3446	681	17	be	be	AUX
gs-3446	681	18	addressed	address	VERB
gs-3446	681	19	to	to	PART
gs-3446	681	20	ensure	ensure	VERB
gs-3446	681	21	the	the	DET
gs-3446	681	22	safety	safety	NOUN
gs-3446	681	23	and	and	CCONJ
gs-3446	681	24	efficacy	efficacy	NOUN
gs-3446	681	25	of	of	ADP
gs-3446	681	26	stem	stem	NOUN
gs-3446	681	27	cell	cell	NOUN
gs-3446	681	28	-	-	PUNCT
gs-3446	681	29	based	base	VERB
gs-3446	681	30	therapies	therapy	NOUN
gs-3446	681	31	.	.	PUNCT
gs-3446	682	1	regulatory	regulatory	ADJ
gs-3446	682	2	frameworks	framework	NOUN
gs-3446	682	3	continue	continue	VERB
gs-3446	682	4	to	to	PART
gs-3446	682	5	evolve	evolve	VERB
gs-3446	682	6	to	to	PART
gs-3446	682	7	balance	balance	VERB
gs-3446	682	8	scientific	scientific	ADJ
gs-3446	682	9	progress	progress	NOUN
gs-3446	682	10	with	with	ADP
gs-3446	682	11	ethical	ethical	ADJ
gs-3446	682	12	considerations	consideration	NOUN
gs-3446	682	13	.	.	PUNCT
gs-3446	683	1	future	future	ADJ
gs-3446	683	2	directions	direction	NOUN
gs-3446	683	3	1	1	NUM
gs-3446	683	4	.	.	PUNCT
gs-3446	683	5	single	single	ADJ
gs-3446	683	6	-	-	PUNCT
gs-3446	683	7	cell	cell	NOUN
gs-3446	683	8	and	and	CCONJ
gs-3446	683	9	multi	multi	ADJ
gs-3446	683	10	-	-	ADJ
gs-3446	683	11	omics	omics	ADJ
gs-3446	683	12	technologies	technology	NOUN
gs-3446	683	13	:	:	PUNCT
gs-3446	683	14	advances	advance	NOUN
gs-3446	683	15	in	in	ADP
gs-3446	683	16	single	single	ADJ
gs-3446	683	17	-	-	PUNCT
gs-3446	683	18	cell	cell	NOUN
gs-3446	683	19	sequencing	sequencing	NOUN
gs-3446	683	20	and	and	CCONJ
gs-3446	683	21	multi	multi	ADJ
gs-3446	683	22	-	-	ADJ
gs-3446	683	23	omics	omics	ADJ
gs-3446	683	24	approaches	approach	NOUN
gs-3446	683	25	will	will	AUX
gs-3446	683	26	provide	provide	VERB
gs-3446	683	27	deeper	deep	ADJ
gs-3446	683	28	insights	insight	NOUN
gs-3446	683	29	into	into	ADP
gs-3446	683	30	stem	stem	NOUN
gs-3446	683	31	cell	cell	NOUN
gs-3446	683	32	heterogeneity	heterogeneity	NOUN
gs-3446	683	33	and	and	CCONJ
gs-3446	683	34	regulatory	regulatory	ADJ
gs-3446	683	35	mechanisms	mechanism	NOUN
gs-3446	683	36	,	,	PUNCT
gs-3446	683	37	enabling	enable	VERB
gs-3446	683	38	more	more	ADV
gs-3446	683	39	precise	precise	ADJ
gs-3446	683	40	control	control	NOUN
gs-3446	683	41	of	of	ADP
gs-3446	683	42	stem	stem	NOUN
gs-3446	683	43	cell	cell	NOUN
gs-3446	683	44	fate	fate	NOUN
gs-3446	683	45	.	.	PUNCT
gs-3446	684	1	for	for	ADP
gs-3446	684	2	example	example	NOUN
gs-3446	684	3	,	,	PUNCT
gs-3446	684	4	integrating	integrate	VERB
gs-3446	684	5	transcriptomics	transcriptomic	NOUN
gs-3446	684	6	,	,	PUNCT
gs-3446	684	7	epigenomics	epigenomic	NOUN
gs-3446	684	8	,	,	PUNCT
gs-3446	684	9	and	and	CCONJ
gs-3446	684	10	proteomics	proteomic	NOUN
gs-3446	684	11	can	can	AUX
gs-3446	684	12	reveal	reveal	VERB
gs-3446	684	13	dynamic	dynamic	ADJ
gs-3446	684	14	changes	change	NOUN
gs-3446	684	15	in	in	ADP
gs-3446	684	16	stem	stem	NOUN
gs-3446	684	17	cell	cell	NOUN
gs-3446	684	18	populations	population	NOUN
gs-3446	684	19	during	during	ADP
gs-3446	684	20	differentiation	differentiation	NOUN
gs-3446	684	21	.	.	PUNCT
gs-3446	685	1	2	2	X
gs-3446	685	2	.	.	X
gs-3446	685	3	bioengineering	bioengineering	NOUN
gs-3446	685	4	and	and	CCONJ
gs-3446	685	5	synthetic	synthetic	ADJ
gs-3446	685	6	biology	biology	NOUN
gs-3446	685	7	:	:	PUNCT
gs-3446	685	8	developing	develop	VERB
gs-3446	685	9	artificial	artificial	ADJ
gs-3446	685	10	niches	niche	NOUN
gs-3446	685	11	and	and	CCONJ
gs-3446	685	12	biomimetic	biomimetic	ADJ
gs-3446	685	13	environments	environment	NOUN
gs-3446	685	14	can	can	AUX
gs-3446	685	15	enhance	enhance	VERB
gs-3446	685	16	stem	stem	NOUN
gs-3446	685	17	cell	cell	NOUN
gs-3446	685	18	survival	survival	NOUN
gs-3446	685	19	,	,	PUNCT
gs-3446	685	20	proliferation	proliferation	NOUN
gs-3446	685	21	,	,	PUNCT
gs-3446	685	22	and	and	CCONJ
gs-3446	685	23	differentiation	differentiation	NOUN
gs-3446	685	24	for	for	ADP
gs-3446	685	25	georgian	georgian	ADJ
gs-3446	685	26	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3446	685	27	მეცნიერები	მეცნიერები	NOUN
gs-3446	685	28	ტ.	ტ.	VERB
gs-3446	685	29	7	7	NUM
gs-3446	685	30	n	n	DET
gs-3446	685	31	1	1	NUM
gs-3446	685	32	,	,	PUNCT
gs-3446	685	33	2025	2025	NUM
gs-3446	685	34	313	313	NUM
gs-3446	685	35	transplantation	transplantation	NOUN
gs-3446	685	36	therapies	therapy	NOUN
gs-3446	685	37	.	.	PUNCT
gs-3446	686	1	for	for	ADP
gs-3446	686	2	instance	instance	NOUN
gs-3446	686	3	,	,	PUNCT
gs-3446	686	4	3d	3d	NUM
gs-3446	686	5	bioprinting	bioprinting	NOUN
gs-3446	686	6	and	and	CCONJ
gs-3446	686	7	organoid	organoid	PROPN
gs-3446	686	8	technology	technology	NOUN
gs-3446	686	9	are	be	AUX
gs-3446	686	10	being	be	AUX
gs-3446	686	11	used	use	VERB
gs-3446	686	12	to	to	PART
gs-3446	686	13	create	create	VERB
gs-3446	686	14	functional	functional	ADJ
gs-3446	686	15	tissues	tissue	NOUN
gs-3446	686	16	for	for	ADP
gs-3446	686	17	regenerative	regenerative	ADJ
gs-3446	686	18	medicine	medicine	NOUN
gs-3446	686	19	.	.	PUNCT
gs-3446	687	1	3	3	X
gs-3446	687	2	.	.	X
gs-3446	687	3	personalized	personalized	ADJ
gs-3446	687	4	medicine	medicine	NOUN
gs-3446	687	5	:	:	PUNCT
gs-3446	687	6	patient	patient	NOUN
gs-3446	687	7	-	-	PUNCT
gs-3446	687	8	specific	specific	ADJ
gs-3446	687	9	ipscs	ipscs	NOUN
gs-3446	687	10	and	and	CCONJ
gs-3446	687	11	crispr	crispr	NOUN
gs-3446	687	12	-	-	PUNCT
gs-3446	687	13	based	base	VERB
gs-3446	687	14	gene	gene	NOUN
gs-3446	687	15	editing	edit	VERB
gs-3446	687	16	offer	offer	VERB
gs-3446	687	17	tailored	tailor	VERB
gs-3446	687	18	solutions	solution	NOUN
gs-3446	687	19	for	for	ADP
gs-3446	687	20	regenerative	regenerative	ADJ
gs-3446	687	21	medicine	medicine	NOUN
gs-3446	687	22	and	and	CCONJ
gs-3446	687	23	disease	disease	NOUN
gs-3446	687	24	modeling	modeling	NOUN
gs-3446	687	25	,	,	PUNCT
gs-3446	687	26	paving	pave	VERB
gs-3446	687	27	the	the	DET
gs-3446	687	28	way	way	NOUN
gs-3446	687	29	for	for	ADP
gs-3446	687	30	precision	precision	NOUN
gs-3446	687	31	therapies	therapy	NOUN
gs-3446	687	32	.	.	PUNCT
gs-3446	688	1	for	for	ADP
gs-3446	688	2	example	example	NOUN
gs-3446	688	3	,	,	PUNCT
gs-3446	688	4	ipsc	ipsc	NOUN
gs-3446	688	5	-	-	PUNCT
gs-3446	688	6	derived	derive	VERB
gs-3446	688	7	cardiomyocytes	cardiomyocyte	NOUN
gs-3446	688	8	are	be	AUX
gs-3446	688	9	being	be	AUX
gs-3446	688	10	explored	explore	VERB
gs-3446	688	11	for	for	ADP
gs-3446	688	12	personalized	personalize	VERB
gs-3446	688	13	heart	heart	NOUN
gs-3446	688	14	repair	repair	NOUN
gs-3446	688	15	.	.	PUNCT
gs-3446	689	1	4	4	X
gs-3446	689	2	.	.	X
gs-3446	689	3	targeting	target	VERB
gs-3446	689	4	aging	age	VERB
gs-3446	689	5	and	and	CCONJ
gs-3446	689	6	degenerative	degenerative	ADJ
gs-3446	689	7	diseases	disease	NOUN
gs-3446	689	8	:	:	PUNCT
gs-3446	689	9	strategies	strategy	NOUN
gs-3446	689	10	to	to	PART
gs-3446	689	11	rejuvenate	rejuvenate	VERB
gs-3446	689	12	aged	aged	ADJ
gs-3446	689	13	stem	stem	NOUN
gs-3446	689	14	cells	cell	NOUN
gs-3446	689	15	and	and	CCONJ
gs-3446	689	16	restore	restore	VERB
gs-3446	689	17	tissue	tissue	NOUN
gs-3446	689	18	homeostasis	homeostasis	NOUN
gs-3446	689	19	hold	hold	NOUN
gs-3446	689	20	promise	promise	NOUN
gs-3446	689	21	for	for	ADP
gs-3446	689	22	treating	treat	VERB
gs-3446	689	23	age	age	NOUN
gs-3446	689	24	-	-	PUNCT
gs-3446	689	25	related	relate	VERB
gs-3446	689	26	diseases	disease	NOUN
gs-3446	689	27	and	and	CCONJ
gs-3446	689	28	extending	extend	VERB
gs-3446	689	29	healthy	healthy	ADJ
gs-3446	689	30	lifespan	lifespan	NOUN
gs-3446	689	31	.	.	PUNCT
gs-3446	690	1	for	for	ADP
gs-3446	690	2	instance	instance	NOUN
gs-3446	690	3	,	,	PUNCT
gs-3446	690	4	epigenetic	epigenetic	ADJ
gs-3446	690	5	reprogramming	reprogramming	NOUN
gs-3446	690	6	using	use	VERB
gs-3446	690	7	yamanaka	yamanaka	PROPN
gs-3446	690	8	factors	factor	NOUN
gs-3446	690	9	(	(	PUNCT
gs-3446	690	10	oct4	oct4	NOUN
gs-3446	690	11	,	,	PUNCT
gs-3446	690	12	sox2	sox2	NOUN
gs-3446	690	13	,	,	PUNCT
gs-3446	690	14	klf4	klf4	NOUN
gs-3446	690	15	,	,	PUNCT
gs-3446	690	16	c	c	NOUN
gs-3446	690	17	-	-	PUNCT
gs-3446	690	18	myc	myc	NOUN
gs-3446	690	19	)	)	PUNCT
gs-3446	690	20	has	have	AUX
gs-3446	690	21	shown	show	VERB
gs-3446	690	22	potential	potential	NOUN
gs-3446	690	23	in	in	ADP
gs-3446	690	24	reversing	reverse	VERB
gs-3446	690	25	age	age	NOUN
gs-3446	690	26	-	-	PUNCT
gs-3446	690	27	related	relate	VERB
gs-3446	690	28	decline	decline	NOUN
gs-3446	690	29	in	in	ADP
gs-3446	690	30	stem	stem	NOUN
gs-3446	690	31	cell	cell	NOUN
gs-3446	690	32	function	function	NOUN
gs-3446	690	33	.	.	PUNCT
gs-3446	691	1	challenges	challenge	NOUN
gs-3446	691	2	and	and	CCONJ
gs-3446	691	3	opportunities	opportunity	NOUN
gs-3446	691	4	despite	despite	SCONJ
gs-3446	691	5	significant	significant	ADJ
gs-3446	691	6	progress	progress	NOUN
gs-3446	691	7	,	,	PUNCT
gs-3446	691	8	several	several	ADJ
gs-3446	691	9	challenges	challenge	NOUN
gs-3446	691	10	remain	remain	VERB
gs-3446	691	11	in	in	ADP
gs-3446	691	12	stem	stem	NOUN
gs-3446	691	13	cell	cell	NOUN
gs-3446	691	14	research	research	NOUN
gs-3446	691	15	.	.	PUNCT
gs-3446	692	1	tumorigenic	tumorigenic	ADJ
gs-3446	692	2	risks	risk	NOUN
gs-3446	692	3	,	,	PUNCT
gs-3446	692	4	immune	immune	ADJ
gs-3446	692	5	rejection	rejection	NOUN
gs-3446	692	6	,	,	PUNCT
gs-3446	692	7	and	and	CCONJ
gs-3446	692	8	long	long	ADJ
gs-3446	692	9	-	-	PUNCT
gs-3446	692	10	term	term	NOUN
gs-3446	692	11	integration	integration	NOUN
gs-3446	692	12	of	of	ADP
gs-3446	692	13	transplanted	transplanted	ADJ
gs-3446	692	14	stem	stem	NOUN
gs-3446	692	15	cells	cell	NOUN
gs-3446	692	16	are	be	AUX
gs-3446	692	17	critical	critical	ADJ
gs-3446	692	18	hurdles	hurdle	NOUN
gs-3446	692	19	that	that	PRON
gs-3446	692	20	must	must	AUX
gs-3446	692	21	be	be	AUX
gs-3446	692	22	addressed	address	VERB
gs-3446	692	23	.	.	PUNCT
gs-3446	693	1	additionally	additionally	ADV
gs-3446	693	2	,	,	PUNCT
gs-3446	693	3	ethical	ethical	ADJ
gs-3446	693	4	concerns	concern	NOUN
gs-3446	693	5	regarding	regard	VERB
gs-3446	693	6	the	the	DET
gs-3446	693	7	use	use	NOUN
gs-3446	693	8	of	of	ADP
gs-3446	693	9	embryonic	embryonic	ADJ
gs-3446	693	10	stem	stem	NOUN
gs-3446	693	11	cells	cell	NOUN
gs-3446	693	12	and	and	CCONJ
gs-3446	693	13	genetic	genetic	ADJ
gs-3446	693	14	modifications	modification	NOUN
gs-3446	693	15	require	require	VERB
gs-3446	693	16	careful	careful	ADJ
gs-3446	693	17	consideration	consideration	NOUN
gs-3446	693	18	.	.	PUNCT
gs-3446	694	1	however	however	ADV
gs-3446	694	2	,	,	PUNCT
gs-3446	694	3	the	the	DET
gs-3446	694	4	rapid	rapid	ADJ
gs-3446	694	5	pace	pace	NOUN
gs-3446	694	6	of	of	ADP
gs-3446	694	7	advancements	advancement	NOUN
gs-3446	694	8	in	in	ADP
gs-3446	694	9	stem	stem	NOUN
gs-3446	694	10	cell	cell	NOUN
gs-3446	694	11	biology	biology	NOUN
gs-3446	694	12	,	,	PUNCT
gs-3446	694	13	gene	gene	NOUN
gs-3446	694	14	editing	editing	NOUN
gs-3446	694	15	,	,	PUNCT
gs-3446	694	16	and	and	CCONJ
gs-3446	694	17	tissue	tissue	NOUN
gs-3446	694	18	engineering	engineering	NOUN
gs-3446	694	19	offers	offer	VERB
gs-3446	694	20	exciting	exciting	ADJ
gs-3446	694	21	opportunities	opportunity	NOUN
gs-3446	694	22	for	for	ADP
gs-3446	694	23	overcoming	overcome	VERB
gs-3446	694	24	these	these	DET
gs-3446	694	25	challenges	challenge	NOUN
gs-3446	694	26	and	and	CCONJ
gs-3446	694	27	translating	translate	VERB
gs-3446	694	28	stem	stem	NOUN
gs-3446	694	29	cell	cell	NOUN
gs-3446	694	30	research	research	NOUN
gs-3446	694	31	into	into	ADP
gs-3446	694	32	clinical	clinical	ADJ
gs-3446	694	33	applications	application	NOUN
gs-3446	694	34	(	(	PUNCT
gs-3446	694	35	aphkhazava	aphkhazava	NOUN
gs-3446	694	36	et	et	PROPN
gs-3446	694	37	al	al	PROPN
gs-3446	694	38	.	.	PROPN
gs-3446	694	39	2024	2024	NUM
gs-3446	694	40	)	)	PUNCT
gs-3446	694	41	.	.	PUNCT
gs-3446	695	1	in	in	ADP
gs-3446	695	2	conclusion	conclusion	NOUN
gs-3446	695	3	,	,	PUNCT
gs-3446	695	4	stem	stem	NOUN
gs-3446	695	5	cell	cell	NOUN
gs-3446	695	6	research	research	NOUN
gs-3446	695	7	represents	represent	VERB
gs-3446	695	8	a	a	DET
gs-3446	695	9	frontier	frontier	NOUN
gs-3446	695	10	in	in	ADP
gs-3446	695	11	biological	biological	ADJ
gs-3446	695	12	and	and	CCONJ
gs-3446	695	13	medical	medical	ADJ
gs-3446	695	14	innovation	innovation	NOUN
gs-3446	695	15	.	.	PUNCT
gs-3446	696	1	by	by	ADP
gs-3446	696	2	integrating	integrate	VERB
gs-3446	696	3	molecular	molecular	ADJ
gs-3446	696	4	insights	insight	NOUN
gs-3446	696	5	with	with	ADP
gs-3446	696	6	technological	technological	ADJ
gs-3446	696	7	advancements	advancement	NOUN
gs-3446	696	8	,	,	PUNCT
gs-3446	696	9	we	we	PRON
gs-3446	696	10	can	can	AUX
gs-3446	696	11	unlock	unlock	VERB
gs-3446	696	12	the	the	DET
gs-3446	696	13	full	full	ADJ
gs-3446	696	14	potential	potential	NOUN
gs-3446	696	15	of	of	ADP
gs-3446	696	16	stem	stem	NOUN
gs-3446	696	17	cells	cell	NOUN
gs-3446	696	18	for	for	ADP
gs-3446	696	19	regenerative	regenerative	ADJ
gs-3446	696	20	medicine	medicine	NOUN
gs-3446	696	21	,	,	PUNCT
gs-3446	696	22	disease	disease	NOUN
gs-3446	696	23	modeling	modeling	NOUN
gs-3446	696	24	,	,	PUNCT
gs-3446	696	25	and	and	CCONJ
gs-3446	696	26	personalized	personalized	ADJ
gs-3446	696	27	healthcare	healthcare	NOUN
gs-3446	696	28	.	.	PUNCT
gs-3446	697	1	continued	continue	VERB
gs-3446	697	2	interdisciplinary	interdisciplinary	ADJ
gs-3446	697	3	collaboration	collaboration	NOUN
gs-3446	697	4	,	,	PUNCT
gs-3446	697	5	ethical	ethical	ADJ
gs-3446	697	6	considerations	consideration	NOUN
gs-3446	697	7	,	,	PUNCT
gs-3446	697	8	and	and	CCONJ
gs-3446	697	9	rigorous	rigorous	ADJ
gs-3446	697	10	regulatory	regulatory	ADJ
gs-3446	697	11	oversight	oversight	NOUN
gs-3446	697	12	will	will	AUX
gs-3446	697	13	be	be	AUX
gs-3446	697	14	essential	essential	ADJ
gs-3446	697	15	to	to	PART
gs-3446	697	16	ensure	ensure	VERB
gs-3446	697	17	the	the	DET
gs-3446	697	18	safe	safe	ADJ
gs-3446	697	19	and	and	CCONJ
gs-3446	697	20	effective	effective	ADJ
gs-3446	697	21	application	application	NOUN
gs-3446	697	22	of	of	ADP
gs-3446	697	23	stem	stem	NOUN
gs-3446	697	24	cell	cell	NOUN
gs-3446	697	25	-	-	PUNCT
gs-3446	697	26	based	base	VERB
gs-3446	697	27	therapies	therapy	NOUN
gs-3446	697	28	in	in	ADP
gs-3446	697	29	the	the	DET
gs-3446	697	30	modern	modern	ADJ
gs-3446	697	31	era	era	NOUN
gs-3446	697	32	.	.	PUNCT
gs-3446	698	1	conclusion	conclusion	NOUN
gs-3446	698	2	stem	stem	NOUN
gs-3446	698	3	cell	cell	NOUN
gs-3446	698	4	systems	system	NOUN
gs-3446	698	5	represent	represent	VERB
gs-3446	698	6	a	a	DET
gs-3446	698	7	transformative	transformative	ADJ
gs-3446	698	8	frontier	frontier	NOUN
gs-3446	698	9	in	in	ADP
gs-3446	698	10	biological	biological	ADJ
gs-3446	698	11	and	and	CCONJ
gs-3446	698	12	medical	medical	ADJ
gs-3446	698	13	research	research	NOUN
gs-3446	698	14	,	,	PUNCT
gs-3446	698	15	offering	offer	VERB
gs-3446	698	16	unprecedented	unprecedented	ADJ
gs-3446	698	17	potential	potential	NOUN
gs-3446	698	18	for	for	ADP
gs-3446	698	19	regenerative	regenerative	ADJ
gs-3446	698	20	medicine	medicine	NOUN
gs-3446	698	21	,	,	PUNCT
gs-3446	698	22	disease	disease	NOUN
gs-3446	698	23	modeling	modeling	NOUN
gs-3446	698	24	,	,	PUNCT
gs-3446	698	25	and	and	CCONJ
gs-3446	698	26	personalized	personalized	ADJ
gs-3446	698	27	healthcare	healthcare	NOUN
gs-3446	698	28	.	.	PUNCT
gs-3446	699	1	the	the	DET
gs-3446	699	2	unique	unique	ADJ
gs-3446	699	3	properties	property	NOUN
gs-3446	699	4	of	of	ADP
gs-3446	699	5	stem	stem	NOUN
gs-3446	699	6	cells	cell	NOUN
gs-3446	699	7	—	—	PUNCT
gs-3446	699	8	self	self	NOUN
gs-3446	699	9	-	-	PUNCT
gs-3446	699	10	renewal	renewal	NOUN
gs-3446	699	11	and	and	CCONJ
gs-3446	699	12	differentiation	differentiation	NOUN
gs-3446	699	13	—	—	PUNCT
gs-3446	699	14	enable	enable	VERB
gs-3446	699	15	them	they	PRON
gs-3446	699	16	to	to	PART
gs-3446	699	17	play	play	VERB
gs-3446	699	18	a	a	DET
gs-3446	699	19	critical	critical	ADJ
gs-3446	699	20	role	role	NOUN
gs-3446	699	21	in	in	ADP
gs-3446	699	22	tissue	tissue	NOUN
gs-3446	699	23	maintenance	maintenance	NOUN
gs-3446	699	24	,	,	PUNCT
gs-3446	699	25	repair	repair	NOUN
gs-3446	699	26	,	,	PUNCT
gs-3446	699	27	and	and	CCONJ
gs-3446	699	28	regeneration	regeneration	NOUN
gs-3446	699	29	.	.	PUNCT
gs-3446	700	1	these	these	DET
gs-3446	700	2	capabilities	capability	NOUN
gs-3446	700	3	hold	hold	VERB
gs-3446	700	4	immense	immense	ADJ
gs-3446	700	5	promise	promise	NOUN
gs-3446	700	6	for	for	ADP
gs-3446	700	7	addressing	address	VERB
gs-3446	700	8	some	some	PRON
gs-3446	700	9	of	of	ADP
gs-3446	700	10	the	the	DET
gs-3446	700	11	most	most	ADV
gs-3446	700	12	pressing	press	VERB
gs-3446	700	13	health	health	NOUN
gs-3446	700	14	challenges	challenge	NOUN
gs-3446	700	15	of	of	ADP
gs-3446	700	16	our	our	PRON
gs-3446	700	17	time	time	NOUN
gs-3446	700	18	,	,	PUNCT
gs-3446	700	19	including	include	VERB
gs-3446	700	20	degenerative	degenerative	ADJ
gs-3446	700	21	diseases	disease	NOUN
gs-3446	700	22	,	,	PUNCT
gs-3446	700	23	injuries	injury	NOUN
gs-3446	700	24	,	,	PUNCT
gs-3446	700	25	and	and	CCONJ
gs-3446	700	26	aging	age	VERB
gs-3446	700	27	-	-	PUNCT
gs-3446	700	28	related	relate	VERB
gs-3446	700	29	conditions	condition	NOUN
gs-3446	700	30	.	.	PUNCT
gs-3446	701	1	however	however	ADV
gs-3446	701	2	,	,	PUNCT
gs-3446	701	3	realizing	realize	VERB
gs-3446	701	4	the	the	DET
gs-3446	701	5	full	full	ADJ
gs-3446	701	6	potential	potential	NOUN
gs-3446	701	7	of	of	ADP
gs-3446	701	8	stem	stem	NOUN
gs-3446	701	9	cell	cell	NOUN
gs-3446	701	10	-	-	PUNCT
gs-3446	701	11	based	base	VERB
gs-3446	701	12	therapies	therapy	NOUN
gs-3446	701	13	requires	require	VERB
gs-3446	701	14	overcoming	overcome	VERB
gs-3446	701	15	significant	significant	ADJ
gs-3446	701	16	challenges	challenge	NOUN
gs-3446	701	17	.	.	PUNCT
gs-3446	702	1	tumorigenicity	tumorigenicity	NOUN
gs-3446	702	2	,	,	PUNCT
gs-3446	702	3	immune	immune	ADJ
gs-3446	702	4	rejection	rejection	NOUN
gs-3446	702	5	,	,	PUNCT
gs-3446	702	6	and	and	CCONJ
gs-3446	702	7	ethical	ethical	ADJ
gs-3446	702	8	concerns	concern	NOUN
gs-3446	702	9	remain	remain	VERB
gs-3446	702	10	critical	critical	ADJ
gs-3446	702	11	barriers	barrier	NOUN
gs-3446	702	12	that	that	PRON
gs-3446	702	13	must	must	AUX
gs-3446	702	14	be	be	AUX
gs-3446	702	15	addressed	address	VERB
gs-3446	702	16	to	to	PART
gs-3446	702	17	ensure	ensure	VERB
gs-3446	702	18	the	the	DET
gs-3446	702	19	safety	safety	NOUN
gs-3446	702	20	and	and	CCONJ
gs-3446	702	21	efficacy	efficacy	NOUN
gs-3446	702	22	of	of	ADP
gs-3446	702	23	stem	stem	NOUN
gs-3446	702	24	cell	cell	NOUN
gs-3446	702	25	applications	application	NOUN
gs-3446	702	26	.	.	PUNCT
gs-3446	703	1	advances	advance	NOUN
gs-3446	703	2	in	in	ADP
gs-3446	703	3	induced	induced	ADJ
gs-3446	703	4	pluripotent	pluripotent	ADJ
gs-3446	703	5	stem	stem	NOUN
gs-3446	703	6	cells	cell	NOUN
gs-3446	703	7	(	(	PUNCT
gs-3446	703	8	ipscs	ipscs	NOUN
gs-3446	703	9	)	)	PUNCT
gs-3446	703	10	,	,	PUNCT
gs-3446	703	11	crispr	crispr	ADJ
gs-3446	703	12	-	-	PUNCT
gs-3446	703	13	cas9	cas9	NOUN
gs-3446	703	14	gene	gene	NOUN
gs-3446	703	15	editing	editing	NOUN
gs-3446	703	16	,	,	PUNCT
gs-3446	703	17	and	and	CCONJ
gs-3446	703	18	tissue	tissue	NOUN
gs-3446	703	19	engineering	engineering	NOUN
gs-3446	703	20	are	be	AUX
gs-3446	703	21	paving	pave	VERB
gs-3446	703	22	the	the	DET
gs-3446	703	23	way	way	NOUN
gs-3446	703	24	for	for	ADP
gs-3446	703	25	innovative	innovative	ADJ
gs-3446	703	26	solutions	solution	NOUN
gs-3446	703	27	,	,	PUNCT
gs-3446	703	28	but	but	CCONJ
gs-3446	703	29	further	further	ADJ
gs-3446	703	30	research	research	NOUN
gs-3446	703	31	is	be	AUX
gs-3446	703	32	needed	need	VERB
gs-3446	703	33	to	to	PART
gs-3446	703	34	refine	refine	VERB
gs-3446	703	35	these	these	DET
gs-3446	703	36	technologies	technology	NOUN
gs-3446	703	37	and	and	CCONJ
gs-3446	703	38	translate	translate	VERB
gs-3446	703	39	them	they	PRON
gs-3446	703	40	into	into	ADP
gs-3446	703	41	clinical	clinical	ADJ
gs-3446	703	42	practice	practice	NOUN
gs-3446	703	43	(	(	PUNCT
gs-3446	703	44	singh	singh	PROPN
gs-3446	703	45	et	et	PROPN
gs-3446	703	46	al	al	PROPN
gs-3446	703	47	.	.	PROPN
gs-3446	703	48	2015	2015	NUM
gs-3446	703	49	)	)	PUNCT
gs-3446	703	50	.	.	PUNCT
gs-3446	704	1	georgian	georgian	ADJ
gs-3446	704	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	704	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	704	4	ტ.	ტ.	VERB
gs-3446	704	5	7	7	NUM
gs-3446	704	6	n	n	DET
gs-3446	704	7	1	1	NUM
gs-3446	704	8	,	,	PUNCT
gs-3446	704	9	2025	2025	NUM
gs-3446	704	10	314	314	NUM
gs-3446	704	11	the	the	DET
gs-3446	704	12	regulation	regulation	NOUN
gs-3446	704	13	of	of	ADP
gs-3446	704	14	stem	stem	NOUN
gs-3446	704	15	cell	cell	NOUN
gs-3446	704	16	homeostasis	homeostasis	NOUN
gs-3446	704	17	,	,	PUNCT
gs-3446	704	18	governed	govern	VERB
gs-3446	704	19	by	by	ADP
gs-3446	704	20	intricate	intricate	ADJ
gs-3446	704	21	transcriptional	transcriptional	ADJ
gs-3446	704	22	networks	network	NOUN
gs-3446	704	23	,	,	PUNCT
gs-3446	704	24	epigenetic	epigenetic	ADJ
gs-3446	704	25	modifications	modification	NOUN
gs-3446	704	26	,	,	PUNCT
gs-3446	704	27	and	and	CCONJ
gs-3446	704	28	niche	niche	NOUN
gs-3446	704	29	signals	signal	NOUN
gs-3446	704	30	,	,	PUNCT
gs-3446	704	31	is	be	AUX
gs-3446	704	32	essential	essential	ADJ
gs-3446	704	33	for	for	ADP
gs-3446	704	34	maintaining	maintain	VERB
gs-3446	704	35	the	the	DET
gs-3446	704	36	balance	balance	NOUN
gs-3446	704	37	between	between	ADP
gs-3446	704	38	self	self	NOUN
gs-3446	704	39	-	-	PUNCT
gs-3446	704	40	renewal	renewal	NOUN
gs-3446	704	41	and	and	CCONJ
gs-3446	704	42	differentiation	differentiation	NOUN
gs-3446	704	43	.	.	PUNCT
gs-3446	705	1	disruptions	disruption	NOUN
gs-3446	705	2	in	in	ADP
gs-3446	705	3	this	this	DET
gs-3446	705	4	balance	balance	NOUN
gs-3446	705	5	can	can	AUX
gs-3446	705	6	lead	lead	VERB
gs-3446	705	7	to	to	ADP
gs-3446	705	8	aging	age	VERB
gs-3446	705	9	,	,	PUNCT
gs-3446	705	10	cancer	cancer	NOUN
gs-3446	705	11	,	,	PUNCT
gs-3446	705	12	and	and	CCONJ
gs-3446	705	13	degenerative	degenerative	ADJ
gs-3446	705	14	diseases	disease	NOUN
gs-3446	705	15	,	,	PUNCT
gs-3446	705	16	highlighting	highlight	VERB
gs-3446	705	17	the	the	DET
gs-3446	705	18	importance	importance	NOUN
gs-3446	705	19	of	of	ADP
gs-3446	705	20	understanding	understand	VERB
gs-3446	705	21	the	the	DET
gs-3446	705	22	molecular	molecular	ADJ
gs-3446	705	23	mechanisms	mechanism	NOUN
gs-3446	705	24	underlying	underlie	VERB
gs-3446	705	25	stem	stem	NOUN
gs-3446	705	26	cell	cell	NOUN
gs-3446	705	27	function	function	NOUN
gs-3446	705	28	.	.	PUNCT
gs-3446	706	1	looking	look	VERB
gs-3446	706	2	ahead	ahead	ADV
gs-3446	706	3	,	,	PUNCT
gs-3446	706	4	the	the	DET
gs-3446	706	5	integration	integration	NOUN
gs-3446	706	6	of	of	ADP
gs-3446	706	7	single	single	ADJ
gs-3446	706	8	-	-	PUNCT
gs-3446	706	9	cell	cell	NOUN
gs-3446	706	10	technologies	technology	NOUN
gs-3446	706	11	,	,	PUNCT
gs-3446	706	12	bioengineering	bioengineering	NOUN
gs-3446	706	13	,	,	PUNCT
gs-3446	706	14	and	and	CCONJ
gs-3446	706	15	synthetic	synthetic	ADJ
gs-3446	706	16	biology	biology	NOUN
gs-3446	706	17	will	will	AUX
gs-3446	706	18	enhance	enhance	VERB
gs-3446	706	19	our	our	PRON
gs-3446	706	20	ability	ability	NOUN
gs-3446	706	21	to	to	PART
gs-3446	706	22	control	control	VERB
gs-3446	706	23	stem	stem	NOUN
gs-3446	706	24	cell	cell	NOUN
gs-3446	706	25	fate	fate	NOUN
gs-3446	706	26	and	and	CCONJ
gs-3446	706	27	improve	improve	VERB
gs-3446	706	28	therapeutic	therapeutic	ADJ
gs-3446	706	29	outcomes	outcome	NOUN
gs-3446	706	30	.	.	PUNCT
gs-3446	707	1	personalized	personalize	VERB
gs-3446	707	2	medicine	medicine	NOUN
gs-3446	707	3	approaches	approach	NOUN
gs-3446	707	4	,	,	PUNCT
gs-3446	707	5	such	such	ADJ
gs-3446	707	6	as	as	ADP
gs-3446	707	7	patient	patient	NOUN
gs-3446	707	8	-	-	PUNCT
gs-3446	707	9	specific	specific	ADJ
gs-3446	707	10	ipscs	ipscs	NOUN
gs-3446	707	11	and	and	CCONJ
gs-3446	707	12	gene	gene	NOUN
gs-3446	707	13	editing	editing	NOUN
gs-3446	707	14	,	,	PUNCT
gs-3446	707	15	offer	offer	VERB
gs-3446	707	16	tailored	tailor	VERB
gs-3446	707	17	solutions	solution	NOUN
gs-3446	707	18	for	for	ADP
gs-3446	707	19	regenerative	regenerative	ADJ
gs-3446	707	20	medicine	medicine	NOUN
gs-3446	707	21	,	,	PUNCT
gs-3446	707	22	while	while	SCONJ
gs-3446	707	23	strategies	strategy	NOUN
gs-3446	707	24	to	to	PART
gs-3446	707	25	rejuvenate	rejuvenate	VERB
gs-3446	707	26	aged	aged	ADJ
gs-3446	707	27	stem	stem	NOUN
gs-3446	707	28	cells	cell	NOUN
gs-3446	707	29	hold	hold	VERB
gs-3446	707	30	promise	promise	NOUN
gs-3446	707	31	for	for	ADP
gs-3446	707	32	treating	treat	VERB
gs-3446	707	33	age	age	NOUN
gs-3446	707	34	-	-	PUNCT
gs-3446	707	35	related	relate	VERB
gs-3446	707	36	diseases	disease	NOUN
gs-3446	707	37	and	and	CCONJ
gs-3446	707	38	extending	extend	VERB
gs-3446	707	39	healthy	healthy	ADJ
gs-3446	707	40	lifespan	lifespan	NOUN
gs-3446	707	41	.	.	PUNCT
gs-3446	708	1	in	in	ADP
gs-3446	708	2	conclusion	conclusion	NOUN
gs-3446	708	3	,	,	PUNCT
gs-3446	708	4	stem	stem	NOUN
gs-3446	708	5	cell	cell	NOUN
gs-3446	708	6	research	research	NOUN
gs-3446	708	7	represents	represent	VERB
gs-3446	708	8	a	a	DET
gs-3446	708	9	paradigm	paradigm	NOUN
gs-3446	708	10	shift	shift	NOUN
gs-3446	708	11	in	in	ADP
gs-3446	708	12	medicine	medicine	NOUN
gs-3446	708	13	,	,	PUNCT
gs-3446	708	14	offering	offer	VERB
gs-3446	708	15	novel	novel	ADJ
gs-3446	708	16	solutions	solution	NOUN
gs-3446	708	17	for	for	ADP
gs-3446	708	18	previously	previously	ADV
gs-3446	708	19	untreatable	untreatable	ADJ
gs-3446	708	20	conditions	condition	NOUN
gs-3446	708	21	.	.	PUNCT
gs-3446	709	1	by	by	ADP
gs-3446	709	2	advancing	advance	VERB
gs-3446	709	3	our	our	PRON
gs-3446	709	4	understanding	understanding	NOUN
gs-3446	709	5	of	of	ADP
gs-3446	709	6	stem	stem	NOUN
gs-3446	709	7	cell	cell	NOUN
gs-3446	709	8	biology	biology	NOUN
gs-3446	709	9	and	and	CCONJ
gs-3446	709	10	leveraging	leverage	VERB
gs-3446	709	11	technological	technological	ADJ
gs-3446	709	12	innovations	innovation	NOUN
gs-3446	709	13	,	,	PUNCT
gs-3446	709	14	we	we	PRON
gs-3446	709	15	can	can	AUX
gs-3446	709	16	unlock	unlock	VERB
gs-3446	709	17	the	the	DET
gs-3446	709	18	full	full	ADJ
gs-3446	709	19	potential	potential	NOUN
gs-3446	709	20	of	of	ADP
gs-3446	709	21	stem	stem	NOUN
gs-3446	709	22	cells	cell	NOUN
gs-3446	709	23	to	to	PART
gs-3446	709	24	improve	improve	VERB
gs-3446	709	25	the	the	DET
gs-3446	709	26	quality	quality	NOUN
gs-3446	709	27	of	of	ADP
gs-3446	709	28	life	life	NOUN
gs-3446	709	29	for	for	ADP
gs-3446	709	30	millions	million	NOUN
gs-3446	709	31	of	of	ADP
gs-3446	709	32	individuals	individual	NOUN
gs-3446	709	33	worldwide	worldwide	ADV
gs-3446	709	34	.	.	PUNCT
gs-3446	710	1	continued	continue	VERB
gs-3446	710	2	interdisciplinary	interdisciplinary	ADJ
gs-3446	710	3	collaboration	collaboration	NOUN
gs-3446	710	4	,	,	PUNCT
gs-3446	710	5	ethical	ethical	ADJ
gs-3446	710	6	considerations	consideration	NOUN
gs-3446	710	7	,	,	PUNCT
gs-3446	710	8	and	and	CCONJ
gs-3446	710	9	rigorous	rigorous	ADJ
gs-3446	710	10	regulatory	regulatory	ADJ
gs-3446	710	11	oversight	oversight	NOUN
gs-3446	710	12	will	will	AUX
gs-3446	710	13	be	be	AUX
gs-3446	710	14	essential	essential	ADJ
gs-3446	710	15	to	to	PART
gs-3446	710	16	ensure	ensure	VERB
gs-3446	710	17	the	the	DET
gs-3446	710	18	safe	safe	ADJ
gs-3446	710	19	and	and	CCONJ
gs-3446	710	20	effective	effective	ADJ
gs-3446	710	21	application	application	NOUN
gs-3446	710	22	of	of	ADP
gs-3446	710	23	stem	stem	NOUN
gs-3446	710	24	cell	cell	NOUN
gs-3446	710	25	-	-	PUNCT
gs-3446	710	26	based	base	VERB
gs-3446	710	27	therapies	therapy	NOUN
gs-3446	710	28	in	in	ADP
gs-3446	710	29	the	the	DET
gs-3446	710	30	modern	modern	ADJ
gs-3446	710	31	era	era	NOUN
gs-3446	710	32	.	.	PUNCT
gs-3446	711	1	references	reference	NOUN
gs-3446	711	2	:	:	PUNCT
gs-3446	712	1	1	1	X
gs-3446	712	2	.	.	X
gs-3446	713	1	adell	adell	PROPN
gs-3446	713	2	,	,	PUNCT
gs-3446	713	3	t.	t.	PROPN
gs-3446	713	4	,	,	PUNCT
gs-3446	713	5	cebrià	cebrià	PROPN
gs-3446	713	6	,	,	PUNCT
gs-3446	713	7	f.	f.	PROPN
gs-3446	713	8	,	,	PUNCT
gs-3446	713	9	&	&	CCONJ
gs-3446	713	10	saló	saló	VERB
gs-3446	713	11	,	,	PUNCT
gs-3446	713	12	e.	e.	PROPN
gs-3446	713	13	(	(	PUNCT
gs-3446	713	14	2010	2010	NUM
gs-3446	713	15	)	)	PUNCT
gs-3446	713	16	.	.	PUNCT
gs-3446	714	1	gradients	gradient	NOUN
gs-3446	714	2	in	in	ADP
gs-3446	714	3	planarian	planarian	ADJ
gs-3446	714	4	regeneration	regeneration	NOUN
gs-3446	714	5	and	and	CCONJ
gs-3446	714	6	homeostasis	homeostasis	NOUN
gs-3446	714	7	.	.	PUNCT
gs-3446	715	1	cold	cold	ADJ
gs-3446	715	2	spring	spring	NOUN
gs-3446	715	3	harbor	harbor	NOUN
gs-3446	715	4	perspectives	perspective	NOUN
gs-3446	715	5	in	in	ADP
gs-3446	715	6	biology	biology	NOUN
gs-3446	715	7	,	,	PUNCT
gs-3446	715	8	2(1	2(1	NUM
gs-3446	715	9	)	)	PUNCT
gs-3446	715	10	,	,	PUNCT
gs-3446	715	11	a000505	a000505	PROPN
gs-3446	715	12	.	.	PUNCT
gs-3446	716	1	https://doi.org/10.1101/cshperspect.a000505	https://doi.org/10.1101/cshperspect.a000505	PROPN
gs-3446	716	2	2	2	NUM
gs-3446	716	3	.	.	X
gs-3446	716	4	aphkhazava	aphkhazava	PROPN
gs-3446	716	5	,	,	PUNCT
gs-3446	716	6	d.	d.	PROPN
gs-3446	716	7	,	,	PUNCT
gs-3446	716	8	sulashvili	sulashvili	NOUN
gs-3446	716	9	,	,	PUNCT
gs-3446	716	10	n.	n.	NOUN
gs-3446	716	11	,	,	PUNCT
gs-3446	716	12	egnatievi	egnatievi	PROPN
gs-3446	716	13	,	,	PUNCT
gs-3446	716	14	i.	i.	NOUN
gs-3446	716	15	,	,	PUNCT
gs-3446	716	16	tupinashvili	tupinashvili	NOUN
gs-3446	716	17	,	,	PUNCT
gs-3446	716	18	t.	t.	PROPN
gs-3446	716	19	,	,	PUNCT
gs-3446	716	20	&	&	CCONJ
gs-3446	716	21	nozadze	nozadze	NOUN
gs-3446	716	22	,	,	PUNCT
gs-3446	716	23	m.	m.	NOUN
gs-3446	716	24	(	(	PUNCT
gs-3446	716	25	2024	2024	NUM
gs-3446	716	26	)	)	PUNCT
gs-3446	716	27	.	.	PUNCT
gs-3446	717	1	dynamic	dynamic	ADJ
gs-3446	717	2	tumor	tumor	NOUN
gs-3446	717	3	microenvironment	microenvironment	NOUN
gs-3446	717	4	theory	theory	NOUN
gs-3446	717	5	:	:	PUNCT
gs-3446	717	6	a	a	DET
gs-3446	717	7	multifaceted	multifaceted	ADJ
gs-3446	717	8	approach	approach	NOUN
gs-3446	717	9	to	to	ADP
gs-3446	717	10	tumor	tumor	NOUN
gs-3446	717	11	research	research	NOUN
gs-3446	717	12	and	and	CCONJ
gs-3446	717	13	biochemistry	biochemistry	NOUN
gs-3446	717	14	.	.	PUNCT
gs-3446	718	1	scientific	scientific	ADJ
gs-3446	718	2	journal	journal	NOUN
gs-3446	718	3	„	„	PUNCT
gs-3446	718	4	spectri	spectri	NOUN
gs-3446	718	5	“	"	PUNCT
gs-3446	718	6	,	,	PUNCT
gs-3446	718	7	9(1	9(1	NUM
gs-3446	718	8	)	)	PUNCT
gs-3446	718	9	.	.	PUNCT
gs-3446	719	1	https://doi.org/10.52340/spectri.2024.09.01.06	https://doi.org/10.52340/spectri.2024.09.01.06	ADP
gs-3446	719	2	3	3	X
gs-3446	719	3	.	.	X
gs-3446	719	4	aphkhazava	aphkhazava	PROPN
gs-3446	719	5	,	,	PUNCT
gs-3446	719	6	d.	d.	PROPN
gs-3446	719	7	,	,	PUNCT
gs-3446	719	8	sulashvili	sulashvili	NOUN
gs-3446	719	9	,	,	PUNCT
gs-3446	719	10	n.	n.	NOUN
gs-3446	719	11	,	,	PUNCT
gs-3446	719	12	tupinashvili	tupinashvili	NOUN
gs-3446	719	13	,	,	PUNCT
gs-3446	719	14	t.	t.	PROPN
gs-3446	719	15	,	,	PUNCT
gs-3446	719	16	&	&	CCONJ
gs-3446	719	17	nozadze	nozadze	NOUN
gs-3446	719	18	,	,	PUNCT
gs-3446	719	19	m.	m.	NOUN
gs-3446	719	20	(	(	PUNCT
gs-3446	719	21	2024	2024	NUM
gs-3446	719	22	)	)	PUNCT
gs-3446	719	23	.	.	PUNCT
gs-3446	720	1	dynamic	dynamic	ADJ
gs-3446	720	2	cellular	cellular	ADJ
gs-3446	720	3	equilibrium	equilibrium	NOUN
gs-3446	720	4	theory	theory	NOUN
gs-3446	720	5	of	of	ADP
gs-3446	720	6	aging	aging	NOUN
gs-3446	720	7	:	:	PUNCT
gs-3446	720	8	integrating	integrate	VERB
gs-3446	720	9	maintenance	maintenance	NOUN
gs-3446	720	10	and	and	CCONJ
gs-3446	720	11	accumulation	accumulation	NOUN
gs-3446	720	12	in	in	ADP
gs-3446	720	13	the	the	DET
gs-3446	720	14	aging	age	VERB
gs-3446	720	15	process	process	NOUN
gs-3446	720	16	.	.	PUNCT
gs-3446	721	1	scientific	scientific	ADJ
gs-3446	721	2	journal	journal	NOUN
gs-3446	721	3	„	„	PUNCT
gs-3446	721	4	spectri	spectri	NOUN
gs-3446	721	5	“	"	PUNCT
gs-3446	721	6	,	,	PUNCT
gs-3446	721	7	8(2	8(2	NUM
gs-3446	721	8	)	)	PUNCT
gs-3446	721	9	.	.	PUNCT
gs-3446	722	1	https://doi.org/10.52340/spectri.2023.08.02.03	https://doi.org/10.52340/spectri.2023.08.02.03	ADJ
gs-3446	722	2	4	4	NUM
gs-3446	722	3	.	.	X
gs-3446	722	4	aphkhazava	aphkhazava	PROPN
gs-3446	722	5	,	,	PUNCT
gs-3446	722	6	d.	d.	PROPN
gs-3446	722	7	,	,	PUNCT
gs-3446	722	8	tuphinashvili	tuphinashvili	NOUN
gs-3446	722	9	,	,	PUNCT
gs-3446	722	10	t.	t.	NOUN
gs-3446	722	11	,	,	PUNCT
gs-3446	722	12	sulashvili	sulashvili	NOUN
gs-3446	722	13	,	,	PUNCT
gs-3446	722	14	n.	n.	NOUN
gs-3446	722	15	,	,	PUNCT
gs-3446	722	16	&	&	CCONJ
gs-3446	722	17	nozadze	nozadze	NOUN
gs-3446	722	18	,	,	PUNCT
gs-3446	722	19	m.	m.	NOUN
gs-3446	722	20	(	(	PUNCT
gs-3446	722	21	2023	2023	NUM
gs-3446	722	22	)	)	PUNCT
gs-3446	722	23	.	.	PUNCT
gs-3446	723	1	the	the	DET
gs-3446	723	2	features	feature	NOUN
gs-3446	723	3	and	and	CCONJ
gs-3446	723	4	role	role	NOUN
gs-3446	723	5	of	of	ADP
gs-3446	723	6	shp2	shp2	ADJ
gs-3446	723	7	protein	protein	NOUN
gs-3446	723	8	in	in	ADP
gs-3446	723	9	postnatal	postnatal	ADJ
gs-3446	723	10	muscle	muscle	NOUN
gs-3446	723	11	development	development	NOUN
gs-3446	723	12	.	.	PUNCT
gs-3446	724	1	scientific	scientific	ADJ
gs-3446	724	2	journal	journal	NOUN
gs-3446	724	3	„	„	PUNCT
gs-3446	724	4	spectri	spectri	NOUN
gs-3446	724	5	“	"	PUNCT
gs-3446	724	6	,	,	PUNCT
gs-3446	724	7	1	1	X
gs-3446	724	8	.	.	PUNCT
gs-3446	725	1	https://doi.org/10.52340/spectri.2023.01	https://doi.org/10.52340/spectri.2023.01	DET
gs-3446	725	2	5	5	NUM
gs-3446	725	3	.	.	X
gs-3446	725	4	baguñà	baguñà	PROPN
gs-3446	725	5	,	,	PUNCT
gs-3446	725	6	j.	j.	PROPN
gs-3446	725	7	,	,	PUNCT
gs-3446	725	8	romero	romero	PROPN
gs-3446	725	9	,	,	PUNCT
gs-3446	725	10	r.	r.	PROPN
gs-3446	725	11	,	,	PUNCT
gs-3446	725	12	saló	saló	VERB
gs-3446	725	13	,	,	PUNCT
gs-3446	725	14	e.	e.	PROPN
gs-3446	725	15	,	,	PUNCT
gs-3446	725	16	collet	collet	PROPN
gs-3446	725	17	,	,	PUNCT
gs-3446	725	18	j.	j.	PROPN
gs-3446	725	19	,	,	PUNCT
gs-3446	725	20	auladell	auladell	VERB
gs-3446	725	21	,	,	PUNCT
gs-3446	725	22	c.	c.	PROPN
gs-3446	725	23	,	,	PUNCT
gs-3446	725	24	ribas	ribas	PROPN
gs-3446	725	25	,	,	PUNCT
gs-3446	725	26	m.	m.	NOUN
gs-3446	725	27	,	,	PUNCT
gs-3446	725	28	riutort	riutort	NOUN
gs-3446	725	29	,	,	PUNCT
gs-3446	725	30	m.	m.	NOUN
gs-3446	725	31	,	,	PUNCT
gs-3446	725	32	garcia	garcia	PROPN
gs-3446	725	33	-	-	PUNCT
gs-3446	725	34	fernandez	fernandez	PROPN
gs-3446	725	35	,	,	PUNCT
gs-3446	725	36	j.	j.	PROPN
gs-3446	725	37	,	,	PUNCT
gs-3446	725	38	burgaya	burgaya	PROPN
gs-3446	725	39	,	,	PUNCT
gs-3446	725	40	f.	f.	PROPN
gs-3446	725	41	,	,	PUNCT
gs-3446	725	42	&	&	CCONJ
gs-3446	725	43	bueno	bueno	PROPN
gs-3446	725	44	,	,	PUNCT
gs-3446	725	45	d.	d.	PROPN
gs-3446	725	46	(	(	PUNCT
gs-3446	725	47	1990	1990	NUM
gs-3446	725	48	)	)	PUNCT
gs-3446	725	49	.	.	PUNCT
gs-3446	726	1	growth	growth	NOUN
gs-3446	726	2	,	,	PUNCT
gs-3446	726	3	degrowth	degrowth	NOUN
gs-3446	726	4	and	and	CCONJ
gs-3446	726	5	regeneration	regeneration	NOUN
gs-3446	726	6	as	as	ADP
gs-3446	726	7	developmental	developmental	ADJ
gs-3446	726	8	phenomena	phenomenon	NOUN
gs-3446	726	9	in	in	ADP
gs-3446	726	10	adult	adult	NOUN
gs-3446	726	11	freshwater	freshwater	NOUN
gs-3446	726	12	planarians	planarian	NOUN
gs-3446	726	13	.	.	PUNCT
gs-3446	727	1	in	in	ADP
gs-3446	727	2	h.-j	h.-j	PROPN
gs-3446	727	3	.	.	PUNCT
gs-3446	728	1	marthy	marthy	ADJ
gs-3446	728	2	(	(	PUNCT
gs-3446	728	3	ed	ed	NOUN
gs-3446	728	4	.	.	PUNCT
gs-3446	728	5	)	)	PUNCT
gs-3446	728	6	,	,	PUNCT
gs-3446	728	7	experimental	experimental	ADJ
gs-3446	728	8	embryology	embryology	NOUN
gs-3446	728	9	in	in	ADP
gs-3446	728	10	aquatic	aquatic	ADJ
gs-3446	728	11	plants	plant	NOUN
gs-3446	728	12	and	and	CCONJ
gs-3446	728	13	animals	animal	NOUN
gs-3446	728	14	(	(	PUNCT
gs-3446	728	15	pp	pp	ADJ
gs-3446	728	16	.	.	PUNCT
gs-3446	729	1	129–162	129–162	NUM
gs-3446	729	2	)	)	PUNCT
gs-3446	729	3	.	.	PUNCT
gs-3446	730	1	plenum	plenum	PROPN
gs-3446	730	2	press	press	PROPN
gs-3446	730	3	.	.	PUNCT
gs-3446	731	1	georgian	georgian	ADJ
gs-3446	731	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	731	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	731	4	ტ.	ტ.	VERB
gs-3446	731	5	7	7	NUM
gs-3446	731	6	n	n	DET
gs-3446	731	7	1	1	NUM
gs-3446	731	8	,	,	PUNCT
gs-3446	731	9	2025	2025	NUM
gs-3446	731	10	315	315	NUM
gs-3446	731	11	6	6	NUM
gs-3446	731	12	.	.	PUNCT
gs-3446	732	1	boyer	boyer	PROPN
gs-3446	732	2	,	,	PUNCT
gs-3446	732	3	l.	l.	PROPN
gs-3446	732	4	a.	a.	PROPN
gs-3446	732	5	,	,	PUNCT
gs-3446	732	6	lee	lee	PROPN
gs-3446	732	7	,	,	PUNCT
gs-3446	732	8	t.	t.	PROPN
gs-3446	732	9	i.	i.	PROPN
gs-3446	732	10	,	,	PUNCT
gs-3446	732	11	cole	cole	PROPN
gs-3446	732	12	,	,	PUNCT
gs-3446	732	13	m.	m.	PROPN
gs-3446	732	14	f.	f.	PROPN
gs-3446	732	15	,	,	PUNCT
gs-3446	732	16	johnstone	johnstone	PROPN
gs-3446	732	17	,	,	PUNCT
gs-3446	732	18	s.	s.	PROPN
gs-3446	732	19	e.	e.	PROPN
gs-3446	732	20	,	,	PUNCT
gs-3446	732	21	levine	levine	PROPN
gs-3446	732	22	,	,	PUNCT
gs-3446	732	23	s.	s.	PROPN
gs-3446	732	24	s.	s.	PROPN
gs-3446	732	25	,	,	PUNCT
gs-3446	732	26	zucker	zucker	PROPN
gs-3446	732	27	,	,	PUNCT
gs-3446	732	28	j.	j.	PROPN
gs-3446	732	29	p.	p.	PROPN
gs-3446	732	30	,	,	PUNCT
gs-3446	732	31	guenther	guenther	PROPN
gs-3446	732	32	,	,	PUNCT
gs-3446	732	33	m.	m.	PROPN
gs-3446	732	34	g.	g.	PROPN
gs-3446	732	35	,	,	PUNCT
gs-3446	732	36	kumar	kumar	PROPN
gs-3446	732	37	,	,	PUNCT
gs-3446	732	38	r.	r.	PROPN
gs-3446	732	39	m.	m.	PROPN
gs-3446	732	40	,	,	PUNCT
gs-3446	732	41	murray	murray	PROPN
gs-3446	732	42	,	,	PUNCT
gs-3446	732	43	h.	h.	PROPN
gs-3446	732	44	l.	l.	PROPN
gs-3446	732	45	,	,	PUNCT
gs-3446	732	46	jenner	jenner	PROPN
gs-3446	732	47	,	,	PUNCT
gs-3446	732	48	r.	r.	PROPN
gs-3446	732	49	g.	g.	PROPN
gs-3446	732	50	,	,	PUNCT
gs-3446	732	51	gifford	gifford	PROPN
gs-3446	732	52	,	,	PUNCT
gs-3446	732	53	d.	d.	PROPN
gs-3446	732	54	k.	k.	PROPN
gs-3446	732	55	,	,	PUNCT
gs-3446	732	56	melton	melton	PROPN
gs-3446	732	57	,	,	PUNCT
gs-3446	732	58	d.	d.	PROPN
gs-3446	732	59	a.	a.	PROPN
gs-3446	732	60	,	,	PUNCT
gs-3446	732	61	jaenisch	jaenisch	PROPN
gs-3446	732	62	,	,	PUNCT
gs-3446	732	63	r.	r.	PROPN
gs-3446	732	64	,	,	PUNCT
gs-3446	732	65	&	&	CCONJ
gs-3446	732	66	young	young	PROPN
gs-3446	732	67	,	,	PUNCT
gs-3446	732	68	r.	r.	PROPN
gs-3446	732	69	a.	a.	PROPN
gs-3446	732	70	(	(	PUNCT
gs-3446	732	71	2005	2005	NUM
gs-3446	732	72	)	)	PUNCT
gs-3446	732	73	.	.	PUNCT
gs-3446	733	1	core	core	NOUN
gs-3446	733	2	transcriptional	transcriptional	ADJ
gs-3446	733	3	regulatory	regulatory	ADJ
gs-3446	733	4	circuitry	circuitry	NOUN
gs-3446	733	5	in	in	ADP
gs-3446	733	6	human	human	ADJ
gs-3446	733	7	embryonic	embryonic	ADJ
gs-3446	733	8	stem	stem	NOUN
gs-3446	733	9	cells	cell	NOUN
gs-3446	733	10	.	.	PUNCT
gs-3446	734	1	cell	cell	NOUN
gs-3446	734	2	,	,	PUNCT
gs-3446	734	3	122(6	122(6	NUM
gs-3446	734	4	)	)	PUNCT
gs-3446	734	5	,	,	PUNCT
gs-3446	734	6	947	947	NUM
gs-3446	734	7	-	-	SYM
gs-3446	734	8	956	956	NUM
gs-3446	734	9	.	.	PUNCT
gs-3446	734	10	https://doi.org/10.1016/j.cell.2005.08.020	https://doi.org/10.1016/j.cell.2005.08.020	PROPN
gs-3446	734	11	7	7	NUM
gs-3446	734	12	.	.	PUNCT
gs-3446	735	1	burnight	burnight	PROPN
gs-3446	735	2	,	,	PUNCT
gs-3446	735	3	e.	e.	PROPN
gs-3446	735	4	r.	r.	PROPN
gs-3446	735	5	,	,	PUNCT
gs-3446	735	6	wiley	wiley	PROPN
gs-3446	735	7	,	,	PUNCT
gs-3446	735	8	l.	l.	PROPN
gs-3446	735	9	a.	a.	PROPN
gs-3446	735	10	,	,	PUNCT
gs-3446	735	11	mullins	mullins	PROPN
gs-3446	735	12	,	,	PUNCT
gs-3446	735	13	r.	r.	PROPN
gs-3446	735	14	f.	f.	PROPN
gs-3446	735	15	,	,	PUNCT
gs-3446	735	16	stone	stone	PROPN
gs-3446	735	17	,	,	PUNCT
gs-3446	735	18	e.	e.	PROPN
gs-3446	735	19	m.	m.	PROPN
gs-3446	735	20	,	,	PUNCT
gs-3446	735	21	&	&	CCONJ
gs-3446	735	22	tucker	tucker	PROPN
gs-3446	735	23	,	,	PUNCT
gs-3446	735	24	b.	b.	PROPN
gs-3446	735	25	a.	a.	PROPN
gs-3446	735	26	(	(	PUNCT
gs-3446	735	27	2015	2015	NUM
gs-3446	735	28	)	)	PUNCT
gs-3446	735	29	.	.	PUNCT
gs-3446	736	1	gene	gene	NOUN
gs-3446	736	2	therapy	therapy	NOUN
gs-3446	736	3	using	use	VERB
gs-3446	736	4	stem	stem	NOUN
gs-3446	736	5	cells	cell	NOUN
gs-3446	736	6	.	.	PUNCT
gs-3446	737	1	cold	cold	ADJ
gs-3446	737	2	spring	spring	NOUN
gs-3446	737	3	harbor	harbor	NOUN
gs-3446	737	4	perspectives	perspective	NOUN
gs-3446	737	5	in	in	ADP
gs-3446	737	6	medicine	medicine	NOUN
gs-3446	737	7	,	,	PUNCT
gs-3446	737	8	5(4	5(4	NUM
gs-3446	737	9	)	)	PUNCT
gs-3446	737	10	,	,	PUNCT
gs-3446	737	11	a017434	a017434	PROPN
gs-3446	737	12	.	.	PUNCT
gs-3446	738	1	https://doi.org/10.1101/cshperspect.a017434	https://doi.org/10.1101/cshperspect.a017434	PROPN
gs-3446	738	2	8	8	NUM
gs-3446	738	3	.	.	PUNCT
gs-3446	739	1	clevers	clever	NOUN
gs-3446	739	2	,	,	PUNCT
gs-3446	739	3	h.	h.	PROPN
gs-3446	739	4	,	,	PUNCT
gs-3446	739	5	&	&	CCONJ
gs-3446	739	6	nusse	nusse	PROPN
gs-3446	739	7	,	,	PUNCT
gs-3446	739	8	r.	r.	PROPN
gs-3446	739	9	(	(	PUNCT
gs-3446	739	10	2012	2012	NUM
gs-3446	739	11	)	)	PUNCT
gs-3446	739	12	.	.	PUNCT
gs-3446	740	1	wnt	wnt	PROPN
gs-3446	740	2	/	/	SYM
gs-3446	740	3	β	β	NOUN
gs-3446	740	4	-	-	ADJ
gs-3446	740	5	catenin	catenin	ADJ
gs-3446	740	6	signaling	signaling	NOUN
gs-3446	740	7	and	and	CCONJ
gs-3446	740	8	disease	disease	NOUN
gs-3446	740	9	.	.	PUNCT
gs-3446	741	1	cell	cell	NOUN
gs-3446	741	2	,	,	PUNCT
gs-3446	741	3	149(5	149(5	NUM
gs-3446	741	4	)	)	PUNCT
gs-3446	741	5	,	,	PUNCT
gs-3446	741	6	1192–1205	1192–1205	NUM
gs-3446	741	7	.	.	PUNCT
gs-3446	742	1	https://doi.org/10.1016/j.cell.2012.05.012	https://doi.org/10.1016/j.cell.2012.05.012	NOUN
gs-3446	742	2	9	9	NUM
gs-3446	742	3	.	.	PUNCT
gs-3446	743	1	clevers	clever	NOUN
gs-3446	743	2	,	,	PUNCT
gs-3446	743	3	h.	h.	PROPN
gs-3446	743	4	(	(	PUNCT
gs-3446	743	5	2011	2011	NUM
gs-3446	743	6	)	)	PUNCT
gs-3446	743	7	.	.	PUNCT
gs-3446	744	1	the	the	DET
gs-3446	744	2	cancer	cancer	NOUN
gs-3446	744	3	stem	stem	NOUN
gs-3446	744	4	cell	cell	NOUN
gs-3446	744	5	:	:	PUNCT
gs-3446	744	6	premises	premise	NOUN
gs-3446	744	7	,	,	PUNCT
gs-3446	744	8	promises	promise	NOUN
gs-3446	744	9	,	,	PUNCT
gs-3446	744	10	and	and	CCONJ
gs-3446	744	11	challenges	challenge	NOUN
gs-3446	744	12	.	.	PUNCT
gs-3446	745	1	nature	nature	NOUN
gs-3446	745	2	medicine	medicine	NOUN
gs-3446	745	3	,	,	PUNCT
gs-3446	745	4	17(3	17(3	NUM
gs-3446	745	5	)	)	PUNCT
gs-3446	745	6	,	,	PUNCT
gs-3446	745	7	313	313	NUM
gs-3446	745	8	-	-	SYM
gs-3446	745	9	319	319	NUM
gs-3446	745	10	.	.	PUNCT
gs-3446	746	1	https://doi.org/10.1038/nm.2304	https://doi.org/10.1038/nm.2304	PROPN
gs-3446	746	2	10	10	NUM
gs-3446	746	3	.	.	PUNCT
gs-3446	746	4	de	de	PROPN
gs-3446	746	5	robertis	robertis	PROPN
gs-3446	746	6	,	,	PUNCT
gs-3446	746	7	e.	e.	PROPN
gs-3446	746	8	m.	m.	PROPN
gs-3446	746	9	(	(	PUNCT
gs-3446	746	10	2009	2009	NUM
gs-3446	746	11	)	)	PUNCT
gs-3446	746	12	.	.	PUNCT
gs-3446	747	1	spemann	spemann	PROPN
gs-3446	747	2	’s	’s	PART
gs-3446	747	3	organizer	organizer	NOUN
gs-3446	747	4	and	and	CCONJ
gs-3446	747	5	the	the	DET
gs-3446	747	6	self	self	NOUN
gs-3446	747	7	-	-	PUNCT
gs-3446	747	8	regulation	regulation	NOUN
gs-3446	747	9	of	of	ADP
gs-3446	747	10	embryonic	embryonic	ADJ
gs-3446	747	11	fields	field	NOUN
gs-3446	747	12	.	.	PUNCT
gs-3446	748	1	mechanisms	mechanism	NOUN
gs-3446	748	2	of	of	ADP
gs-3446	748	3	development	development	NOUN
gs-3446	748	4	,	,	PUNCT
gs-3446	748	5	126(11–12	126(11–12	NUM
gs-3446	748	6	)	)	PUNCT
gs-3446	748	7	,	,	PUNCT
gs-3446	748	8	925–941	925–941	NUM
gs-3446	748	9	.	.	PUNCT
gs-3446	749	1	https://doi.org/10.1016/j.mod.2009.08.004	https://doi.org/10.1016/j.mod.2009.08.004	VERB
gs-3446	749	2	11	11	NUM
gs-3446	749	3	.	.	PUNCT
gs-3446	750	1	dlx	dlx	NOUN
gs-3446	750	2	and	and	CCONJ
gs-3446	750	3	sp6	sp6	NOUN
gs-3446	750	4	-	-	SYM
gs-3446	750	5	9	9	NUM
gs-3446	750	6	control	control	NOUN
gs-3446	750	7	optic	optic	PROPN
gs-3446	750	8	cup	cup	NOUN
gs-3446	750	9	regeneration	regeneration	NOUN
gs-3446	750	10	in	in	ADP
gs-3446	750	11	a	a	DET
gs-3446	750	12	prototypic	prototypic	ADJ
gs-3446	750	13	eye	eye	NOUN
gs-3446	750	14	.	.	PUNCT
gs-3446	751	1	plos	plos	PROPN
gs-3446	751	2	genetics	genetics	PROPN
gs-3446	751	3	,	,	PUNCT
gs-3446	751	4	7(8	7(8	NUM
gs-3446	751	5	)	)	PUNCT
gs-3446	751	6	,	,	PUNCT
gs-3446	751	7	e1002226	e1002226	PROPN
gs-3446	751	8	.	.	PUNCT
gs-3446	752	1	https://doi.org/10.1371/journal.pgen.1002226	https://doi.org/10.1371/journal.pgen.1002226	PROPN
gs-3446	752	2	12	12	NUM
gs-3446	752	3	.	.	PUNCT
gs-3446	753	1	dominici	dominici	PROPN
gs-3446	753	2	,	,	PUNCT
gs-3446	753	3	m.	m.	NOUN
gs-3446	753	4	,	,	PUNCT
gs-3446	753	5	le	le	X
gs-3446	753	6	blanc	blanc	NOUN
gs-3446	753	7	,	,	PUNCT
gs-3446	753	8	k.	k.	PROPN
gs-3446	753	9	,	,	PUNCT
gs-3446	753	10	mueller	mueller	PROPN
gs-3446	753	11	,	,	PUNCT
gs-3446	753	12	i.	i.	PROPN
gs-3446	753	13	,	,	PUNCT
gs-3446	753	14	slaper	slaper	NOUN
gs-3446	753	15	-	-	PUNCT
gs-3446	753	16	cortenbach	cortenbach	NOUN
gs-3446	753	17	,	,	PUNCT
gs-3446	753	18	i.	i.	PROPN
gs-3446	753	19	,	,	PUNCT
gs-3446	753	20	marini	marini	PROPN
gs-3446	753	21	,	,	PUNCT
gs-3446	753	22	f.	f.	PROPN
gs-3446	753	23	,	,	PUNCT
gs-3446	753	24	krause	krause	PROPN
gs-3446	753	25	,	,	PUNCT
gs-3446	753	26	d.	d.	PROPN
gs-3446	753	27	,	,	PUNCT
gs-3446	753	28	deans	deans	PROPN
gs-3446	753	29	,	,	PUNCT
gs-3446	753	30	r.	r.	PROPN
gs-3446	753	31	,	,	PUNCT
gs-3446	753	32	keating	keating	NOUN
gs-3446	753	33	,	,	PUNCT
gs-3446	753	34	a.	a.	NOUN
gs-3446	753	35	,	,	PUNCT
gs-3446	753	36	prockop	prockop	PROPN
gs-3446	753	37	,	,	PUNCT
gs-3446	753	38	d.	d.	PROPN
gs-3446	753	39	,	,	PUNCT
gs-3446	753	40	&	&	CCONJ
gs-3446	753	41	horwitz	horwitz	PROPN
gs-3446	753	42	,	,	PUNCT
gs-3446	753	43	e.	e.	PROPN
gs-3446	753	44	(	(	PUNCT
gs-3446	753	45	2006	2006	NUM
gs-3446	753	46	)	)	PUNCT
gs-3446	753	47	.	.	PUNCT
gs-3446	754	1	minimal	minimal	ADJ
gs-3446	754	2	criteria	criterion	NOUN
gs-3446	754	3	for	for	ADP
gs-3446	754	4	defining	define	VERB
gs-3446	754	5	multipotent	multipotent	NOUN
gs-3446	754	6	mesenchymal	mesenchymal	ADJ
gs-3446	754	7	stromal	stromal	ADJ
gs-3446	754	8	cells	cell	NOUN
gs-3446	754	9	.	.	PUNCT
gs-3446	755	1	the	the	DET
gs-3446	755	2	international	international	ADJ
gs-3446	755	3	society	society	NOUN
gs-3446	755	4	for	for	ADP
gs-3446	755	5	cellular	cellular	ADJ
gs-3446	755	6	therapy	therapy	NOUN
gs-3446	755	7	position	position	NOUN
gs-3446	755	8	statement	statement	NOUN
gs-3446	755	9	.	.	PUNCT
gs-3446	756	1	cytotherapy	cytotherapy	NOUN
gs-3446	756	2	,	,	PUNCT
gs-3446	756	3	8(4	8(4	NUM
gs-3446	756	4	)	)	PUNCT
gs-3446	756	5	,	,	PUNCT
gs-3446	756	6	315	315	NUM
gs-3446	756	7	-	-	SYM
gs-3446	756	8	317	317	NUM
gs-3446	756	9	.	.	PUNCT
gs-3446	757	1	https://doi.org/10.1080/14653240600855905	https://doi.org/10.1080/14653240600855905	VERB
gs-3446	757	2	13	13	NUM
gs-3446	757	3	.	.	PUNCT
gs-3446	758	1	felix	felix	PROPN
gs-3446	758	2	,	,	PUNCT
gs-3446	758	3	d.	d.	PROPN
gs-3446	758	4	a.	a.	PROPN
gs-3446	758	5	,	,	PUNCT
gs-3446	758	6	&	&	CCONJ
gs-3446	758	7	aboobaker	aboobaker	PROPN
gs-3446	758	8	,	,	PUNCT
gs-3446	758	9	a.	a.	NOUN
gs-3446	758	10	a.	a.	NOUN
gs-3446	758	11	(	(	PUNCT
gs-3446	758	12	2010	2010	NUM
gs-3446	758	13	)	)	PUNCT
gs-3446	758	14	.	.	PUNCT
gs-3446	759	1	the	the	DET
gs-3446	759	2	tale	tale	ADJ
gs-3446	759	3	class	class	NOUN
gs-3446	759	4	homeobox	homeobox	PROPN
gs-3446	759	5	gene	gene	NOUN
gs-3446	759	6	smed	sme	VERB
gs-3446	759	7	-	-	PUNCT
gs-3446	759	8	prep	prep	NOUN
gs-3446	759	9	defines	define	VERB
gs-3446	759	10	the	the	DET
gs-3446	759	11	anterior	anterior	ADJ
gs-3446	759	12	compartment	compartment	NOUN
gs-3446	759	13	for	for	ADP
gs-3446	759	14	head	head	NOUN
gs-3446	759	15	regeneration	regeneration	NOUN
gs-3446	759	16	.	.	PUNCT
gs-3446	760	1	plos	plos	PROPN
gs-3446	760	2	genetics	genetics	PROPN
gs-3446	760	3	,	,	PUNCT
gs-3446	760	4	6(9	6(9	NUM
gs-3446	760	5	)	)	PUNCT
gs-3446	760	6	,	,	PUNCT
gs-3446	760	7	e1000915	e1000915	NOUN
gs-3446	760	8	.	.	PUNCT
gs-3446	761	1	https://doi.org/10.1371/journal.pgen.1000915	https://doi.org/10.1371/journal.pgen.1000915	PROPN
gs-3446	761	2	14	14	NUM
gs-3446	761	3	.	.	PUNCT
gs-3446	762	1	gomes	gome	NOUN
gs-3446	762	2	,	,	PUNCT
gs-3446	762	3	f.	f.	PROPN
gs-3446	762	4	l.	l.	PROPN
gs-3446	762	5	a.	a.	PROPN
gs-3446	762	6	f.	f.	PROPN
gs-3446	762	7	,	,	PUNCT
gs-3446	762	8	zhang	zhang	PROPN
gs-3446	762	9	,	,	PUNCT
gs-3446	762	10	g.	g.	PROPN
gs-3446	762	11	,	,	PUNCT
gs-3446	762	12	carbonell	carbonell	PROPN
gs-3446	762	13	,	,	PUNCT
gs-3446	762	14	f.	f.	PROPN
gs-3446	762	15	,	,	PUNCT
gs-3446	762	16	correa	correa	PROPN
gs-3446	762	17	,	,	PUNCT
gs-3446	762	18	j.	j.	PROPN
gs-3446	762	19	a.	a.	PROPN
gs-3446	762	20	,	,	PUNCT
gs-3446	762	21	harris	harris	PROPN
gs-3446	762	22	,	,	PUNCT
gs-3446	762	23	w.	w.	PROPN
gs-3446	762	24	a.	a.	PROPN
gs-3446	762	25	,	,	PUNCT
gs-3446	762	26	simons	simons	PROPN
gs-3446	762	27	,	,	PUNCT
gs-3446	762	28	b.	b.	PROPN
gs-3446	762	29	d.	d.	PROPN
gs-3446	762	30	,	,	PUNCT
gs-3446	762	31	&	&	CCONJ
gs-3446	762	32	cayouette	cayouette	NOUN
gs-3446	762	33	,	,	PUNCT
gs-3446	762	34	m.	m.	NOUN
gs-3446	762	35	(	(	PUNCT
gs-3446	762	36	2011	2011	NUM
gs-3446	762	37	)	)	PUNCT
gs-3446	762	38	.	.	PUNCT
gs-3446	763	1	reconstruction	reconstruction	NOUN
gs-3446	763	2	of	of	ADP
gs-3446	763	3	rat	rat	NOUN
gs-3446	763	4	retinal	retinal	ADJ
gs-3446	763	5	progenitor	progenitor	NOUN
gs-3446	763	6	cell	cell	NOUN
gs-3446	763	7	lineages	lineage	NOUN
gs-3446	763	8	in	in	ADP
gs-3446	763	9	vitro	vitro	X
gs-3446	763	10	reveals	reveal	VERB
gs-3446	763	11	a	a	DET
gs-3446	763	12	surprising	surprising	ADJ
gs-3446	763	13	degree	degree	NOUN
gs-3446	763	14	of	of	ADP
gs-3446	763	15	stochasticity	stochasticity	NOUN
gs-3446	763	16	in	in	ADP
gs-3446	763	17	cell	cell	NOUN
gs-3446	763	18	fate	fate	NOUN
gs-3446	763	19	decisions	decision	NOUN
gs-3446	763	20	.	.	PUNCT
gs-3446	764	1	development	development	NOUN
gs-3446	764	2	,	,	PUNCT
gs-3446	764	3	138(2	138(2	NUM
gs-3446	764	4	)	)	PUNCT
gs-3446	764	5	,	,	PUNCT
gs-3446	764	6	227–235	227–235	NUM
gs-3446	764	7	.	.	PUNCT
gs-3446	764	8	https://doi.org/10.1242/dev.059659	https://doi.org/10.1242/dev.059659	PROPN
gs-3446	764	9	15	15	NUM
gs-3446	764	10	.	.	PUNCT
gs-3446	765	1	gorgaslidze	gorgaslidze	PROPN
gs-3446	765	2	,	,	PUNCT
gs-3446	765	3	n.	n.	NOUN
gs-3446	765	4	,	,	PUNCT
gs-3446	765	5	sulashvili	sulashvili	NOUN
gs-3446	765	6	,	,	PUNCT
gs-3446	765	7	n.	n.	NOUN
gs-3446	765	8	,	,	PUNCT
gs-3446	765	9	gabunia	gabunia	NOUN
gs-3446	765	10	,	,	PUNCT
gs-3446	765	11	l.	l.	PROPN
gs-3446	765	12	,	,	PUNCT
gs-3446	765	13	ratiani	ratiani	PROPN
gs-3446	765	14	,	,	PUNCT
gs-3446	765	15	l.	l.	PROPN
gs-3446	765	16	,	,	PUNCT
gs-3446	765	17	&	&	CCONJ
gs-3446	765	18	giorgobiani	giorgobiani	PROPN
gs-3446	765	19	,	,	PUNCT
gs-3446	765	20	m.	m.	NOUN
gs-3446	765	21	(	(	PUNCT
gs-3446	765	22	2023	2023	NUM
gs-3446	765	23	)	)	PUNCT
gs-3446	765	24	.	.	PUNCT
gs-3446	766	1	the	the	DET
gs-3446	766	2	singularities	singularity	NOUN
gs-3446	766	3	of	of	ADP
gs-3446	766	4	temozolimide	temozolimide	ADJ
gs-3446	766	5	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-3446	766	6	effects	effect	NOUN
gs-3446	766	7	in	in	ADP
gs-3446	766	8	brain	brain	NOUN
gs-3446	766	9	effects	effect	NOUN
gs-3446	766	10	in	in	ADP
gs-3446	766	11	brain	brain	NOUN
gs-3446	766	12	tumor	tumor	NOUN
gs-3446	766	13	therapeutic	therapeutic	ADJ
gs-3446	766	14	applications	application	NOUN
gs-3446	766	15	.	.	PUNCT
gs-3446	767	1	experimental	experimental	ADJ
gs-3446	767	2	and	and	CCONJ
gs-3446	767	3	clinical	clinical	ADJ
gs-3446	767	4	medicine	medicine	NOUN
gs-3446	767	5	georgia	georgia	PROPN
gs-3446	767	6	,	,	PUNCT
gs-3446	767	7	(	(	PUNCT
gs-3446	767	8	4	4	NUM
gs-3446	767	9	)	)	PUNCT
gs-3446	767	10	,	,	PUNCT
gs-3446	767	11	62–66	62–66	PROPN
gs-3446	767	12	.	.	PUNCT
gs-3446	768	1	https://doi.org/10.52340/jecm.2023.04.16	https://doi.org/10.52340/jecm.2023.04.16	PROPN
gs-3446	768	2	16	16	NUM
gs-3446	768	3	.	.	PUNCT
gs-3446	769	1	gurley	gurley	PROPN
gs-3446	769	2	,	,	PUNCT
gs-3446	769	3	k.	k.	PROPN
gs-3446	769	4	a.	a.	PROPN
gs-3446	769	5	,	,	PUNCT
gs-3446	769	6	rink	rink	NOUN
gs-3446	769	7	,	,	PUNCT
gs-3446	769	8	j.	j.	PROPN
gs-3446	769	9	c.	c.	PROPN
gs-3446	769	10	,	,	PUNCT
gs-3446	769	11	&	&	CCONJ
gs-3446	769	12	sánchez	sánchez	PROPN
gs-3446	769	13	alvarado	alvarado	PROPN
gs-3446	769	14	,	,	PUNCT
gs-3446	769	15	a.	a.	PROPN
gs-3446	769	16	(	(	PUNCT
gs-3446	769	17	2008	2008	NUM
gs-3446	769	18	)	)	PUNCT
gs-3446	769	19	.	.	PUNCT
gs-3446	770	1	beta	beta	NOUN
gs-3446	770	2	-	-	PUNCT
gs-3446	770	3	catenin	catenin	NOUN
gs-3446	770	4	defines	define	NOUN
gs-3446	770	5	head	head	NOUN
gs-3446	770	6	versus	versus	ADP
gs-3446	770	7	tail	tail	NOUN
gs-3446	770	8	identity	identity	NOUN
gs-3446	770	9	during	during	ADP
gs-3446	770	10	planarian	planarian	ADJ
gs-3446	770	11	regeneration	regeneration	NOUN
gs-3446	770	12	and	and	CCONJ
gs-3446	770	13	homeostasis	homeostasis	NOUN
gs-3446	770	14	.	.	PUNCT
gs-3446	771	1	science	science	NOUN
gs-3446	771	2	,	,	PUNCT
gs-3446	771	3	319(5861	319(5861	PROPN
gs-3446	771	4	)	)	PUNCT
gs-3446	771	5	,	,	PUNCT
gs-3446	771	6	323–327	323–327	NUM
gs-3446	771	7	.	.	PUNCT
gs-3446	771	8	https://doi.org/10.1126/science.1150029	https://doi.org/10.1126/science.1150029	PROPN
gs-3446	771	9	17	17	NUM
gs-3446	771	10	.	.	PUNCT
gs-3446	772	1	halpern	halpern	PROPN
gs-3446	772	2	,	,	PUNCT
gs-3446	772	3	j.	j.	PROPN
gs-3446	772	4	,	,	PUNCT
gs-3446	772	5	o'hara	o'hara	PROPN
gs-3446	772	6	,	,	PUNCT
gs-3446	772	7	s.	s.	PROPN
gs-3446	772	8	e.	e.	PROPN
gs-3446	772	9	,	,	PUNCT
gs-3446	772	10	doxzen	doxzen	PROPN
gs-3446	772	11	,	,	PUNCT
gs-3446	772	12	k.	k.	PROPN
gs-3446	772	13	w.	w.	PROPN
gs-3446	772	14	,	,	PUNCT
gs-3446	772	15	witkowsky	witkowsky	PROPN
gs-3446	772	16	,	,	PUNCT
gs-3446	772	17	l.	l.	PROPN
gs-3446	772	18	b.	b.	PROPN
gs-3446	772	19	,	,	PUNCT
gs-3446	772	20	&	&	CCONJ
gs-3446	772	21	owen	owen	PROPN
gs-3446	772	22	,	,	PUNCT
gs-3446	772	23	a.	a.	PROPN
gs-3446	772	24	l.	l.	PROPN
gs-3446	772	25	(	(	PUNCT
gs-3446	772	26	2019	2019	NUM
gs-3446	772	27	)	)	PUNCT
gs-3446	772	28	.	.	PUNCT
gs-3446	773	1	societal	societal	ADJ
gs-3446	773	2	and	and	CCONJ
gs-3446	773	3	ethical	ethical	ADJ
gs-3446	773	4	impacts	impact	NOUN
gs-3446	773	5	of	of	ADP
gs-3446	773	6	germline	germline	NOUN
gs-3446	773	7	genome	genome	NOUN
gs-3446	773	8	editing	editing	NOUN
gs-3446	773	9	:	:	PUNCT
gs-3446	773	10	how	how	SCONJ
gs-3446	773	11	can	can	AUX
gs-3446	773	12	we	we	PRON
gs-3446	773	13	secure	secure	VERB
gs-3446	773	14	human	human	ADJ
gs-3446	773	15	rights	right	NOUN
gs-3446	773	16	?	?	PUNCT
gs-3446	774	1	the	the	DET
gs-3446	774	2	crispr	crispr	ADJ
gs-3446	774	3	journal	journal	NOUN
gs-3446	774	4	,	,	PUNCT
gs-3446	774	5	2(5	2(5	NUM
gs-3446	774	6	)	)	PUNCT
gs-3446	774	7	,	,	PUNCT
gs-3446	774	8	293–298	293–298	NUM
gs-3446	774	9	.	.	PUNCT
gs-3446	775	1	https://doi.org/10.1089/crispr.2019.0029	https://doi.org/10.1089/crispr.2019.0029	PROPN
gs-3446	775	2	18	18	NUM
gs-3446	775	3	.	.	PUNCT
gs-3446	776	1	hayashi	hayashi	PROPN
gs-3446	776	2	,	,	PUNCT
gs-3446	776	3	t.	t.	PROPN
gs-3446	776	4	,	,	PUNCT
gs-3446	776	5	motoishi	motoishi	NOUN
gs-3446	776	6	,	,	PUNCT
gs-3446	776	7	m.	m.	NOUN
gs-3446	776	8	,	,	PUNCT
gs-3446	776	9	yazawa	yazawa	PROPN
gs-3446	776	10	,	,	PUNCT
gs-3446	776	11	s.	s.	PROPN
gs-3446	776	12	,	,	PUNCT
gs-3446	776	13	itomi	itomi	NOUN
gs-3446	776	14	,	,	PUNCT
gs-3446	776	15	k.	k.	PROPN
gs-3446	776	16	,	,	PUNCT
gs-3446	776	17	tanegashima	tanegashima	PROPN
gs-3446	776	18	,	,	PUNCT
gs-3446	776	19	c.	c.	PROPN
gs-3446	776	20	,	,	PUNCT
gs-3446	776	21	nishimura	nishimura	PROPN
gs-3446	776	22	,	,	PUNCT
gs-3446	776	23	o.	o.	PROPN
gs-3446	776	24	,	,	PUNCT
gs-3446	776	25	agata	agata	PROPN
gs-3446	776	26	,	,	PUNCT
gs-3446	776	27	k.	k.	PROPN
gs-3446	776	28	,	,	PUNCT
gs-3446	776	29	&	&	CCONJ
gs-3446	776	30	tarui	tarui	PROPN
gs-3446	776	31	,	,	PUNCT
gs-3446	776	32	h.	h.	PROPN
gs-3446	776	33	(	(	PUNCT
gs-3446	776	34	2011	2011	NUM
gs-3446	776	35	)	)	PUNCT
gs-3446	776	36	.	.	PUNCT
gs-3446	777	1	a	a	DET
gs-3446	777	2	lim	lim	PROPN
gs-3446	777	3	-	-	PUNCT
gs-3446	777	4	homeobox	homeobox	NOUN
gs-3446	777	5	gene	gene	NOUN
gs-3446	777	6	is	be	AUX
gs-3446	777	7	required	require	VERB
gs-3446	777	8	for	for	ADP
gs-3446	777	9	differentiation	differentiation	NOUN
gs-3446	777	10	of	of	ADP
gs-3446	777	11	wnt	wnt	NOUN
gs-3446	777	12	-	-	PUNCT
gs-3446	777	13	expressing	express	VERB
gs-3446	777	14	cells	cell	NOUN
gs-3446	777	15	georgian	georgian	ADJ
gs-3446	777	16	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3446	777	17	მეცნიერები	მეცნიერები	NOUN
gs-3446	777	18	ტ.	ტ.	VERB
gs-3446	777	19	7	7	NUM
gs-3446	777	20	n	n	DET
gs-3446	777	21	1	1	NUM
gs-3446	777	22	,	,	PUNCT
gs-3446	777	23	2025	2025	NUM
gs-3446	777	24	316	316	NUM
gs-3446	777	25	at	at	ADP
gs-3446	777	26	the	the	DET
gs-3446	777	27	posterior	posterior	ADJ
gs-3446	777	28	end	end	NOUN
gs-3446	777	29	of	of	ADP
gs-3446	777	30	the	the	DET
gs-3446	777	31	planarian	planarian	ADJ
gs-3446	777	32	body	body	NOUN
gs-3446	777	33	.	.	PUNCT
gs-3446	778	1	development	development	NOUN
gs-3446	778	2	,	,	PUNCT
gs-3446	778	3	138(17	138(17	NUM
gs-3446	778	4	)	)	PUNCT
gs-3446	778	5	,	,	PUNCT
gs-3446	778	6	3679–3688	3679–3688	NUM
gs-3446	778	7	.	.	PUNCT
gs-3446	779	1	https://doi.org/10.1242/dev.066852	https://doi.org/10.1242/dev.066852	PROPN
gs-3446	779	2	19	19	NUM
gs-3446	779	3	.	.	PUNCT
gs-3446	780	1	iglesias	iglesias	PROPN
gs-3446	780	2	,	,	PUNCT
gs-3446	780	3	m.	m.	NOUN
gs-3446	780	4	,	,	PUNCT
gs-3446	780	5	gómez	gómez	NOUN
gs-3446	780	6	-	-	PUNCT
gs-3446	780	7	skarmeta	skarmeta	NOUN
gs-3446	780	8	,	,	PUNCT
gs-3446	780	9	j.	j.	PROPN
gs-3446	780	10	l.	l.	PROPN
gs-3446	780	11	,	,	PUNCT
gs-3446	780	12	saló	saló	VERB
gs-3446	780	13	,	,	PUNCT
gs-3446	780	14	e.	e.	PROPN
gs-3446	780	15	,	,	PUNCT
gs-3446	780	16	&	&	CCONJ
gs-3446	780	17	adell	adell	PROPN
gs-3446	780	18	,	,	PUNCT
gs-3446	780	19	t.	t.	PROPN
gs-3446	780	20	(	(	PUNCT
gs-3446	780	21	2008	2008	NUM
gs-3446	780	22	)	)	PUNCT
gs-3446	780	23	.	.	PUNCT
gs-3446	781	1	silencing	silence	VERB
gs-3446	781	2	of	of	ADP
gs-3446	781	3	smed	sme	VERB
gs-3446	781	4	-	-	PUNCT
gs-3446	781	5	betacatenin1	betacatenin1	NOUN
gs-3446	781	6	generates	generate	VERB
gs-3446	781	7	radial	radial	ADJ
gs-3446	781	8	-	-	PUNCT
gs-3446	781	9	like	like	ADJ
gs-3446	781	10	hypercephalized	hypercephalize	VERB
gs-3446	781	11	planarians	planarian	NOUN
gs-3446	781	12	.	.	PUNCT
gs-3446	782	1	development	development	NOUN
gs-3446	782	2	,	,	PUNCT
gs-3446	782	3	135(7	135(7	NUM
gs-3446	782	4	)	)	PUNCT
gs-3446	782	5	,	,	PUNCT
gs-3446	782	6	1215–1221	1215–1221	NUM
gs-3446	782	7	.	.	PUNCT
gs-3446	783	1	https://doi.org/10.1242/dev.020289	https://doi.org/10.1242/dev.020289	ADJ
gs-3446	783	2	20	20	NUM
gs-3446	783	3	.	.	PUNCT
gs-3446	784	1	jaba	jaba	PROPN
gs-3446	784	2	,	,	PUNCT
gs-3446	784	3	t.	t.	PROPN
gs-3446	784	4	(	(	PUNCT
gs-3446	784	5	2022	2022	NUM
gs-3446	784	6	)	)	PUNCT
gs-3446	784	7	.	.	PUNCT
gs-3446	785	1	dasatinib	dasatinib	NOUN
gs-3446	785	2	and	and	CCONJ
gs-3446	785	3	quercetin	quercetin	NOUN
gs-3446	785	4	:	:	PUNCT
gs-3446	785	5	short	short	ADJ
gs-3446	785	6	-	-	PUNCT
gs-3446	785	7	term	term	NOUN
gs-3446	785	8	simultaneous	simultaneous	ADJ
gs-3446	785	9	administration	administration	NOUN
gs-3446	785	10	yields	yield	VERB
gs-3446	785	11	senolytic	senolytic	ADJ
gs-3446	785	12	effect	effect	NOUN
gs-3446	785	13	in	in	ADP
gs-3446	785	14	humans	human	NOUN
gs-3446	785	15	.	.	PUNCT
gs-3446	786	1	issues	issue	NOUN
gs-3446	786	2	and	and	CCONJ
gs-3446	786	3	developments	development	NOUN
gs-3446	786	4	in	in	ADP
gs-3446	786	5	medicine	medicine	NOUN
gs-3446	786	6	and	and	CCONJ
gs-3446	786	7	medical	medical	ADJ
gs-3446	786	8	research	research	NOUN
gs-3446	786	9	vol	vol	NOUN
gs-3446	786	10	.	.	PROPN
gs-3446	786	11	2	2	NUM
gs-3446	786	12	,	,	PUNCT
gs-3446	786	13	22	22	NUM
gs-3446	786	14	-	-	SYM
gs-3446	786	15	31	31	NUM
gs-3446	786	16	.	.	PUNCT
gs-3446	787	1	lapan	lapan	NOUN
gs-3446	787	2	,	,	PUNCT
gs-3446	787	3	s.	s.	PROPN
gs-3446	787	4	w.	w.	PROPN
gs-3446	787	5	,	,	PUNCT
gs-3446	787	6	&	&	CCONJ
gs-3446	787	7	reddien	reddien	PROPN
gs-3446	787	8	,	,	PUNCT
gs-3446	787	9	p.	p.	PROPN
gs-3446	787	10	w.	w.	PROPN
gs-3446	787	11	(	(	PUNCT
gs-3446	787	12	2011	2011	NUM
gs-3446	787	13	)	)	PUNCT
gs-3446	787	14	.	.	PUNCT
gs-3446	788	1	21	21	NUM
gs-3446	788	2	.	.	X
gs-3446	788	3	liska	liska	PROPN
gs-3446	788	4	,	,	PUNCT
gs-3446	788	5	m.	m.	NOUN
gs-3446	788	6	g.	g.	PROPN
gs-3446	788	7	,	,	PUNCT
gs-3446	788	8	crowley	crowley	PROPN
gs-3446	788	9	,	,	PUNCT
gs-3446	788	10	m.	m.	NOUN
gs-3446	788	11	g.	g.	PROPN
gs-3446	788	12	,	,	PUNCT
gs-3446	788	13	&	&	CCONJ
gs-3446	788	14	borlongan	borlongan	NOUN
gs-3446	788	15	,	,	PUNCT
gs-3446	788	16	c.	c.	PROPN
gs-3446	788	17	v.	v.	PROPN
gs-3446	788	18	(	(	PUNCT
gs-3446	788	19	2017	2017	NUM
gs-3446	788	20	)	)	PUNCT
gs-3446	788	21	.	.	PUNCT
gs-3446	789	1	regulated	regulate	VERB
gs-3446	789	2	and	and	CCONJ
gs-3446	789	3	unregulated	unregulated	ADJ
gs-3446	789	4	clinical	clinical	ADJ
gs-3446	789	5	trials	trial	NOUN
gs-3446	789	6	of	of	ADP
gs-3446	789	7	stem	stem	NOUN
gs-3446	789	8	cell	cell	NOUN
gs-3446	789	9	therapies	therapy	NOUN
gs-3446	789	10	for	for	ADP
gs-3446	789	11	stroke	stroke	NOUN
gs-3446	789	12	.	.	PUNCT
gs-3446	790	1	translational	translational	ADJ
gs-3446	790	2	stroke	stroke	PROPN
gs-3446	790	3	research	research	PROPN
gs-3446	790	4	,	,	PUNCT
gs-3446	790	5	8(2	8(2	NUM
gs-3446	790	6	)	)	PUNCT
gs-3446	790	7	,	,	PUNCT
gs-3446	790	8	93–103	93–103	X
gs-3446	790	9	.	.	PROPN
gs-3446	790	10	https://doi.org/10.1007/s12975-016-0504-4	https://doi.org/10.1007/s12975-016-0504-4	NUM
gs-3446	790	11	22	22	NUM
gs-3446	790	12	.	.	PUNCT
gs-3446	791	1	lobo	lobo	PROPN
gs-3446	791	2	,	,	PUNCT
gs-3446	791	3	d.	d.	PROPN
gs-3446	791	4	,	,	PUNCT
gs-3446	791	5	beane	beane	PROPN
gs-3446	791	6	,	,	PUNCT
gs-3446	791	7	w.	w.	PROPN
gs-3446	791	8	s.	s.	PROPN
gs-3446	791	9	,	,	PUNCT
gs-3446	791	10	&	&	CCONJ
gs-3446	791	11	levin	levin	PROPN
gs-3446	791	12	,	,	PUNCT
gs-3446	791	13	m.	m.	NOUN
gs-3446	791	14	(	(	PUNCT
gs-3446	791	15	2012	2012	NUM
gs-3446	791	16	)	)	PUNCT
gs-3446	791	17	.	.	PUNCT
gs-3446	792	1	modeling	model	VERB
gs-3446	792	2	planarian	planarian	ADJ
gs-3446	792	3	regeneration	regeneration	NOUN
gs-3446	792	4	:	:	PUNCT
gs-3446	792	5	a	a	DET
gs-3446	792	6	primer	primer	NOUN
gs-3446	792	7	for	for	ADP
gs-3446	792	8	reverse	reverse	NOUN
gs-3446	792	9	-	-	PUNCT
gs-3446	792	10	engineering	engineer	VERB
gs-3446	792	11	the	the	DET
gs-3446	792	12	worm	worm	NOUN
gs-3446	792	13	.	.	PUNCT
gs-3446	793	1	plos	plos	PROPN
gs-3446	793	2	computational	computational	ADJ
gs-3446	793	3	biology	biology	NOUN
gs-3446	793	4	,	,	PUNCT
gs-3446	793	5	8(8	8(8	NUM
gs-3446	793	6	)	)	PUNCT
gs-3446	793	7	,	,	PUNCT
gs-3446	793	8	e1002481	e1002481	NOUN
gs-3446	793	9	.	.	PUNCT
gs-3446	794	1	https://doi.org/10.1371/journal.pcbi.1002481	https://doi.org/10.1371/journal.pcbi.1002481	PROPN
gs-3446	794	2	23	23	NUM
gs-3446	794	3	.	.	PUNCT
gs-3446	795	1	meinhardt	meinhardt	PROPN
gs-3446	795	2	,	,	PUNCT
gs-3446	795	3	h.	h.	PROPN
gs-3446	795	4	(	(	PUNCT
gs-3446	795	5	2009	2009	NUM
gs-3446	795	6	)	)	PUNCT
gs-3446	795	7	.	.	PUNCT
gs-3446	796	1	beta	beta	NOUN
gs-3446	796	2	-	-	PUNCT
gs-3446	796	3	catenin	catenin	NOUN
gs-3446	796	4	and	and	CCONJ
gs-3446	796	5	axis	axis	ADJ
gs-3446	796	6	formation	formation	NOUN
gs-3446	796	7	in	in	ADP
gs-3446	796	8	planarians	planarian	NOUN
gs-3446	796	9	.	.	PUNCT
gs-3446	797	1	bioessays	bioessay	NOUN
gs-3446	797	2	,	,	PUNCT
gs-3446	797	3	31(1	31(1	NUM
gs-3446	797	4	)	)	PUNCT
gs-3446	797	5	,	,	PUNCT
gs-3446	797	6	5–9	5–9	PROPN
gs-3446	797	7	.	.	PUNCT
gs-3446	797	8	https://doi.org/10.1002/bies.080194	https://doi.org/10.1002/bies.080194	PROPN
gs-3446	797	9	24	24	NUM
gs-3446	797	10	.	.	PUNCT
gs-3446	798	1	morrison	morrison	PROPN
gs-3446	798	2	,	,	PUNCT
gs-3446	798	3	s.	s.	PROPN
gs-3446	798	4	j.	j.	PROPN
gs-3446	798	5	,	,	PUNCT
gs-3446	798	6	&	&	CCONJ
gs-3446	798	7	spradling	spradling	PROPN
gs-3446	798	8	,	,	PUNCT
gs-3446	798	9	a.	a.	PROPN
gs-3446	798	10	c.	c.	PROPN
gs-3446	798	11	(	(	PUNCT
gs-3446	798	12	2008	2008	NUM
gs-3446	798	13	)	)	PUNCT
gs-3446	798	14	.	.	PUNCT
gs-3446	799	1	stem	stem	NOUN
gs-3446	799	2	cells	cell	NOUN
gs-3446	799	3	and	and	CCONJ
gs-3446	799	4	niches	niche	NOUN
gs-3446	799	5	:	:	PUNCT
gs-3446	799	6	mechanisms	mechanism	NOUN
gs-3446	799	7	that	that	PRON
gs-3446	799	8	promote	promote	VERB
gs-3446	799	9	stem	stem	NOUN
gs-3446	799	10	cell	cell	NOUN
gs-3446	799	11	maintenance	maintenance	NOUN
gs-3446	799	12	throughout	throughout	ADP
gs-3446	799	13	life	life	NOUN
gs-3446	799	14	.	.	PUNCT
gs-3446	800	1	cell	cell	NOUN
gs-3446	800	2	,	,	PUNCT
gs-3446	800	3	132(4	132(4	NUM
gs-3446	800	4	)	)	PUNCT
gs-3446	800	5	,	,	PUNCT
gs-3446	800	6	598	598	NUM
gs-3446	800	7	-	-	SYM
gs-3446	800	8	611	611	NUM
gs-3446	800	9	.	.	PUNCT
gs-3446	801	1	https://doi.org/10.1016/j.cell.2008.01.038	https://doi.org/10.1016/j.cell.2008.01.038	NOUN
gs-3446	801	2	25	25	NUM
gs-3446	801	3	.	.	PUNCT
gs-3446	802	1	newmark	newmark	PROPN
gs-3446	802	2	,	,	PUNCT
gs-3446	802	3	p.	p.	PROPN
gs-3446	802	4	a.	a.	PROPN
gs-3446	802	5	,	,	PUNCT
gs-3446	802	6	wang	wang	PROPN
gs-3446	802	7	,	,	PUNCT
gs-3446	802	8	y.	y.	PROPN
gs-3446	802	9	,	,	PUNCT
gs-3446	802	10	&	&	CCONJ
gs-3446	802	11	chong	chong	PROPN
gs-3446	802	12	,	,	PUNCT
gs-3446	802	13	t.	t.	PROPN
gs-3446	802	14	(	(	PUNCT
gs-3446	802	15	2008	2008	NUM
gs-3446	802	16	)	)	PUNCT
gs-3446	802	17	.	.	PUNCT
gs-3446	803	1	germ	germ	NOUN
gs-3446	803	2	cell	cell	NOUN
gs-3446	803	3	specification	specification	NOUN
gs-3446	803	4	and	and	CCONJ
gs-3446	803	5	regeneration	regeneration	NOUN
gs-3446	803	6	in	in	ADP
gs-3446	803	7	planarians	planarian	NOUN
gs-3446	803	8	.	.	PUNCT
gs-3446	804	1	cold	cold	ADJ
gs-3446	804	2	spring	spring	NOUN
gs-3446	804	3	harbor	harbor	NOUN
gs-3446	804	4	symposia	symposia	NOUN
gs-3446	804	5	on	on	ADP
gs-3446	804	6	quantitative	quantitative	ADJ
gs-3446	804	7	biology	biology	NOUN
gs-3446	804	8	,	,	PUNCT
gs-3446	804	9	73	73	NUM
gs-3446	804	10	,	,	PUNCT
gs-3446	804	11	573–581	573–581	NUM
gs-3446	804	12	.	.	PUNCT
gs-3446	805	1	https://doi.org/10.1101/sqb.2008.73.022	https://doi.org/10.1101/sqb.2008.73.022	DET
gs-3446	805	2	26	26	NUM
gs-3446	805	3	.	.	PUNCT
gs-3446	806	1	orkin	orkin	PROPN
gs-3446	806	2	,	,	PUNCT
gs-3446	806	3	s.	s.	PROPN
gs-3446	806	4	h.	h.	PROPN
gs-3446	806	5	,	,	PUNCT
gs-3446	806	6	&	&	CCONJ
gs-3446	806	7	zon	zon	PROPN
gs-3446	806	8	,	,	PUNCT
gs-3446	806	9	l.	l.	PROPN
gs-3446	806	10	i.	i.	PROPN
gs-3446	806	11	(	(	PUNCT
gs-3446	806	12	2008	2008	NUM
gs-3446	806	13	)	)	PUNCT
gs-3446	806	14	.	.	PUNCT
gs-3446	807	1	hematopoiesis	hematopoiesis	NOUN
gs-3446	807	2	:	:	PUNCT
gs-3446	807	3	an	an	DET
gs-3446	807	4	evolving	evolve	VERB
gs-3446	807	5	paradigm	paradigm	NOUN
gs-3446	807	6	for	for	ADP
gs-3446	807	7	stem	stem	NOUN
gs-3446	807	8	cell	cell	NOUN
gs-3446	807	9	biology	biology	NOUN
gs-3446	807	10	.	.	PUNCT
gs-3446	808	1	cell	cell	NOUN
gs-3446	808	2	,	,	PUNCT
gs-3446	808	3	132(4	132(4	NUM
gs-3446	808	4	)	)	PUNCT
gs-3446	808	5	,	,	PUNCT
gs-3446	808	6	631	631	NUM
gs-3446	808	7	-	-	SYM
gs-3446	808	8	644	644	NUM
gs-3446	808	9	.	.	PUNCT
gs-3446	809	1	https://doi.org/10.1016/j.cell.2008.01.025	https://doi.org/10.1016/j.cell.2008.01.025	PROPN
gs-3446	809	2	27	27	NUM
gs-3446	809	3	.	.	PUNCT
gs-3446	810	1	park	park	NOUN
gs-3446	810	2	,	,	PUNCT
gs-3446	810	3	j.	j.	PROPN
gs-3446	810	4	s.	s.	PROPN
gs-3446	810	5	,	,	PUNCT
gs-3446	810	6	suryaprakash	suryaprakash	NOUN
gs-3446	810	7	,	,	PUNCT
gs-3446	810	8	s.	s.	PROPN
gs-3446	810	9	,	,	PUNCT
gs-3446	810	10	lao	lao	PROPN
gs-3446	810	11	,	,	PUNCT
gs-3446	810	12	y.	y.	PROPN
gs-3446	810	13	h.	h.	PROPN
gs-3446	810	14	,	,	PUNCT
gs-3446	810	15	&	&	CCONJ
gs-3446	810	16	leong	leong	PROPN
gs-3446	810	17	,	,	PUNCT
gs-3446	810	18	k.	k.	PROPN
gs-3446	810	19	w.	w.	PROPN
gs-3446	810	20	(	(	PUNCT
gs-3446	810	21	2015	2015	NUM
gs-3446	810	22	)	)	PUNCT
gs-3446	810	23	.	.	PUNCT
gs-3446	811	1	engineering	engineer	VERB
gs-3446	811	2	mesenchymal	mesenchymal	NOUN
gs-3446	811	3	stem	stem	NOUN
gs-3446	811	4	cells	cell	NOUN
gs-3446	811	5	for	for	ADP
gs-3446	811	6	regenerative	regenerative	ADJ
gs-3446	811	7	medicine	medicine	NOUN
gs-3446	811	8	and	and	CCONJ
gs-3446	811	9	drug	drug	NOUN
gs-3446	811	10	delivery	delivery	NOUN
gs-3446	811	11	.	.	PUNCT
gs-3446	812	1	methods	method	NOUN
gs-3446	812	2	,	,	PUNCT
gs-3446	812	3	84	84	NUM
gs-3446	812	4	,	,	PUNCT
gs-3446	812	5	3–16	3–16	NOUN
gs-3446	812	6	.	.	PUNCT
gs-3446	813	1	https://doi.org/10.1016/j.ymeth.2015.03.002	https://doi.org/10.1016/j.ymeth.2015.03.002	PROPN
gs-3446	813	2	28	28	NUM
gs-3446	813	3	.	.	PUNCT
gs-3446	814	1	saitou	saitou	PROPN
gs-3446	814	2	,	,	PUNCT
gs-3446	814	3	m.	m.	NOUN
gs-3446	814	4	,	,	PUNCT
gs-3446	814	5	&	&	CCONJ
gs-3446	814	6	yamaji	yamaji	PROPN
gs-3446	814	7	,	,	PUNCT
gs-3446	814	8	m.	m.	NOUN
gs-3446	814	9	(	(	PUNCT
gs-3446	814	10	2012	2012	NUM
gs-3446	814	11	)	)	PUNCT
gs-3446	814	12	.	.	PUNCT
gs-3446	815	1	primordial	primordial	ADJ
gs-3446	815	2	germ	germ	NOUN
gs-3446	815	3	cells	cell	NOUN
gs-3446	815	4	in	in	ADP
gs-3446	815	5	mice	mouse	NOUN
gs-3446	815	6	.	.	PUNCT
gs-3446	816	1	cold	cold	ADJ
gs-3446	816	2	spring	spring	NOUN
gs-3446	816	3	harbor	harbor	NOUN
gs-3446	816	4	perspectives	perspective	NOUN
gs-3446	816	5	in	in	ADP
gs-3446	816	6	biology	biology	NOUN
gs-3446	816	7	,	,	PUNCT
gs-3446	816	8	4(11	4(11	NUM
gs-3446	816	9	)	)	PUNCT
gs-3446	816	10	,	,	PUNCT
gs-3446	816	11	a008375	a008375	PROPN
gs-3446	816	12	.	.	PUNCT
gs-3446	817	1	https://doi.org/10.1101/cshperspect.a008375	https://doi.org/10.1101/cshperspect.a008375	PROPN
gs-3446	817	2	29	29	NUM
gs-3446	817	3	.	.	PUNCT
gs-3446	818	1	scharf	scharf	PROPN
gs-3446	818	2	b	b	PROPN
gs-3446	818	3	,	,	PUNCT
gs-3446	818	4	clement	clement	PROPN
gs-3446	818	5	cc	cc	PROPN
gs-3446	818	6	,	,	PUNCT
gs-3446	818	7	yodmuang	yodmuang	PROPN
gs-3446	818	8	s	s	PROPN
gs-3446	818	9	,	,	PUNCT
gs-3446	818	10	urbanska	urbanska	ADJ
gs-3446	818	11	am	am	NOUN
gs-3446	818	12	,	,	PUNCT
gs-3446	818	13	suadicani	suadicani	VERB
gs-3446	818	14	so	so	ADV
gs-3446	818	15	,	,	PUNCT
gs-3446	818	16	aphkhazava	aphkhazava	NOUN
gs-3446	818	17	d	d	NOUN
gs-3446	818	18	,	,	PUNCT
gs-3446	818	19	thi	thi	INTJ
gs-3446	818	20	mm	mm	PROPN
gs-3446	818	21	,	,	PUNCT
gs-3446	818	22	perino	perino	PROPN
gs-3446	818	23	g	g	PROPN
gs-3446	818	24	,	,	PUNCT
gs-3446	818	25	hardin	hardin	PROPN
gs-3446	818	26	ja	ja	PROPN
gs-3446	818	27	,	,	PUNCT
gs-3446	818	28	cobelli	cobelli	PROPN
gs-3446	818	29	n	n	CCONJ
gs-3446	818	30	,	,	PUNCT
gs-3446	818	31	vunjak	vunjak	PROPN
gs-3446	818	32	-	-	PUNCT
gs-3446	818	33	novakovic	novakovic	ADV
gs-3446	818	34	g	g	PROPN
gs-3446	818	35	,	,	PUNCT
gs-3446	818	36	santambrogio	santambrogio	PROPN
gs-3446	818	37	l.	l.	PROPN
gs-3446	818	38	(	(	PUNCT
gs-3446	818	39	2013	2013	NUM
gs-3446	818	40	):	):	PUNCT
gs-3446	818	41	age	age	NOUN
gs-3446	818	42	related	relate	VERB
gs-3446	818	43	carbonylation	carbonylation	NOUN
gs-3446	818	44	of	of	ADP
gs-3446	818	45	fibrocartilage	fibrocartilage	ADJ
gs-3446	818	46	structural	structural	ADJ
gs-3446	818	47	proteins	protein	NOUN
gs-3446	818	48	drives	drive	VERB
gs-3446	818	49	tissue	tissue	NOUN
gs-3446	818	50	degenerative	degenerative	VERB
gs-3446	818	51	modification.chem	modification.chem	PROPN
gs-3446	818	52	biol	biol	NOUN
gs-3446	818	53	.	.	PUNCT
gs-3446	819	1	25;20(7	25;20(7	NUM
gs-3446	819	2	):	):	PUNCT
gs-3446	819	3	922	922	NUM
gs-3446	819	4	-	-	SYM
gs-3446	819	5	34	34	NUM
gs-3446	819	6	.	.	NOUN
gs-3446	819	7	30	30	NUM
gs-3446	819	8	.	.	PUNCT
gs-3446	820	1	schmidt	schmidt	PROPN
gs-3446	820	2	,	,	PUNCT
gs-3446	820	3	r.	r.	PROPN
gs-3446	820	4	,	,	PUNCT
gs-3446	820	5	&	&	CCONJ
gs-3446	820	6	plath	plath	PROPN
gs-3446	820	7	,	,	PUNCT
gs-3446	820	8	k.	k.	PROPN
gs-3446	820	9	(	(	PUNCT
gs-3446	820	10	2012	2012	NUM
gs-3446	820	11	)	)	PUNCT
gs-3446	820	12	.	.	PUNCT
gs-3446	821	1	the	the	DET
gs-3446	821	2	roles	role	NOUN
gs-3446	821	3	of	of	ADP
gs-3446	821	4	the	the	DET
gs-3446	821	5	reprogramming	reprogramme	VERB
gs-3446	821	6	factors	factor	NOUN
gs-3446	821	7	oct4	oct4	ADJ
gs-3446	821	8	,	,	PUNCT
gs-3446	821	9	sox2	sox2	NOUN
gs-3446	821	10	and	and	CCONJ
gs-3446	821	11	klf4	klf4	NOUN
gs-3446	821	12	in	in	ADP
gs-3446	821	13	resetting	reset	VERB
gs-3446	821	14	the	the	DET
gs-3446	821	15	somatic	somatic	ADJ
gs-3446	821	16	cell	cell	NOUN
gs-3446	821	17	epigenome	epigenome	NOUN
gs-3446	821	18	during	during	ADP
gs-3446	821	19	induced	induced	ADJ
gs-3446	821	20	pluripotent	pluripotent	ADJ
gs-3446	821	21	stem	stem	NOUN
gs-3446	821	22	cell	cell	NOUN
gs-3446	821	23	generation	generation	NOUN
gs-3446	821	24	.	.	PUNCT
gs-3446	822	1	genome	genome	NOUN
gs-3446	822	2	biology	biology	NOUN
gs-3446	822	3	,	,	PUNCT
gs-3446	822	4	13(10	13(10	NUM
gs-3446	822	5	)	)	PUNCT
gs-3446	822	6	,	,	PUNCT
gs-3446	822	7	251	251	NUM
gs-3446	822	8	.	.	PUNCT
gs-3446	823	1	https://doi.org/10.1186/gb-2012-13-10-251	https://doi.org/10.1186/gb-2012-13-10-251	PROPN
gs-3446	823	2	31	31	NUM
gs-3446	823	3	.	.	PUNCT
gs-3446	824	1	sharma	sharma	PROPN
gs-3446	824	2	,	,	PUNCT
gs-3446	824	3	a.	a.	PROPN
gs-3446	824	4	,	,	PUNCT
gs-3446	824	5	mir	mir	PROPN
gs-3446	824	6	,	,	PUNCT
gs-3446	824	7	r.	r.	PROPN
gs-3446	824	8	,	,	PUNCT
gs-3446	824	9	&	&	CCONJ
gs-3446	824	10	galande	galande	PROPN
gs-3446	824	11	,	,	PUNCT
gs-3446	824	12	s.	s.	PROPN
gs-3446	824	13	(	(	PUNCT
gs-3446	824	14	2021	2021	NUM
gs-3446	824	15	)	)	PUNCT
gs-3446	824	16	.	.	PUNCT
gs-3446	825	1	epigenetic	epigenetic	ADJ
gs-3446	825	2	regulation	regulation	NOUN
gs-3446	825	3	of	of	ADP
gs-3446	825	4	the	the	DET
gs-3446	825	5	wnt	wnt	PROPN
gs-3446	825	6	/	/	SYM
gs-3446	825	7	β	β	NOUN
gs-3446	825	8	-	-	ADJ
gs-3446	825	9	catenin	catenin	ADJ
gs-3446	825	10	signaling	signal	VERB
gs-3446	825	11	pathway	pathway	NOUN
gs-3446	825	12	in	in	ADP
gs-3446	825	13	cancer	cancer	NOUN
gs-3446	825	14	.	.	PUNCT
gs-3446	826	1	frontiers	frontier	NOUN
gs-3446	826	2	in	in	ADP
gs-3446	826	3	genetics	genetic	NOUN
gs-3446	826	4	,	,	PUNCT
gs-3446	826	5	12	12	NUM
gs-3446	826	6	,	,	PUNCT
gs-3446	826	7	681053	681053	NUM
gs-3446	826	8	.	.	PUNCT
gs-3446	827	1	https://doi.org/10.3389/fgene.2021.681053	https://doi.org/10.3389/fgene.2021.681053	PROPN
gs-3446	827	2	georgian	georgian	ADJ
gs-3446	827	3	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3446	827	4	მეცნიერები	მეცნიერები	NOUN
gs-3446	827	5	ტ.	ტ.	VERB
gs-3446	827	6	7	7	NUM
gs-3446	827	7	n	n	PRON
gs-3446	827	8	1	1	NUM
gs-3446	827	9	,	,	PUNCT
gs-3446	827	10	2025	2025	NUM
gs-3446	827	11	317	317	NUM
gs-3446	827	12	32	32	NUM
gs-3446	827	13	.	.	PUNCT
gs-3446	828	1	singh	singh	PROPN
gs-3446	828	2	,	,	PUNCT
gs-3446	828	3	v.	v.	PROPN
gs-3446	828	4	k.	k.	PROPN
gs-3446	828	5	,	,	PUNCT
gs-3446	828	6	kalsan	kalsan	ADV
gs-3446	828	7	,	,	PUNCT
gs-3446	828	8	m.	m.	NOUN
gs-3446	828	9	,	,	PUNCT
gs-3446	828	10	kumar	kumar	PROPN
gs-3446	828	11	,	,	PUNCT
gs-3446	828	12	n.	n.	PROPN
gs-3446	828	13	,	,	PUNCT
gs-3446	828	14	saini	saini	PROPN
gs-3446	828	15	,	,	PUNCT
gs-3446	828	16	a.	a.	PROPN
gs-3446	828	17	,	,	PUNCT
gs-3446	828	18	&	&	CCONJ
gs-3446	828	19	chandra	chandra	PROPN
gs-3446	828	20	,	,	PUNCT
gs-3446	828	21	r.	r.	PROPN
gs-3446	828	22	(	(	PUNCT
gs-3446	828	23	2015	2015	NUM
gs-3446	828	24	)	)	PUNCT
gs-3446	828	25	.	.	PUNCT
gs-3446	829	1	induced	induce	VERB
gs-3446	829	2	pluripotent	pluripotent	ADJ
gs-3446	829	3	stem	stem	NOUN
gs-3446	829	4	cells	cell	NOUN
gs-3446	829	5	:	:	PUNCT
gs-3446	829	6	applications	application	NOUN
gs-3446	829	7	in	in	ADP
gs-3446	829	8	regenerative	regenerative	ADJ
gs-3446	829	9	medicine	medicine	NOUN
gs-3446	829	10	,	,	PUNCT
gs-3446	829	11	disease	disease	NOUN
gs-3446	829	12	modeling	modeling	NOUN
gs-3446	829	13	,	,	PUNCT
gs-3446	829	14	and	and	CCONJ
gs-3446	829	15	drug	drug	NOUN
gs-3446	829	16	discovery	discovery	NOUN
gs-3446	829	17	.	.	PUNCT
gs-3446	830	1	frontiers	frontier	NOUN
gs-3446	830	2	in	in	ADP
gs-3446	830	3	cell	cell	NOUN
gs-3446	830	4	and	and	CCONJ
gs-3446	830	5	developmental	developmental	ADJ
gs-3446	830	6	biology	biology	NOUN
gs-3446	830	7	,	,	PUNCT
gs-3446	830	8	3	3	NUM
gs-3446	830	9	,	,	PUNCT
gs-3446	830	10	2	2	NUM
gs-3446	830	11	.	.	PUNCT
gs-3446	831	1	https://doi.org/10.3389/fcell.2015.00002	https://doi.org/10.3389/fcell.2015.00002	PROPN
gs-3446	831	2	33	33	NUM
gs-3446	831	3	.	.	PUNCT
gs-3446	831	4	sulashvili	sulashvili	NOUN
gs-3446	831	5	,	,	PUNCT
gs-3446	831	6	n.	n.	NOUN
gs-3446	831	7	.	.	PUNCT
gs-3446	832	1	.	.	PUNCT
gs-3446	832	2	,	,	PUNCT
gs-3446	833	1	gorgaslidze	gorgaslidze	INTJ
gs-3446	833	2	,	,	PUNCT
gs-3446	833	3	n.	n.	PROPN
gs-3446	833	4	.	.	PUNCT
gs-3446	834	1	,	,	PUNCT
gs-3446	834	2	beglaryan	beglaryan	ADJ
gs-3446	834	3	,	,	PUNCT
gs-3446	834	4	m.	m.	NOUN
gs-3446	834	5	.	.	PUNCT
gs-3446	834	6	,	,	PUNCT
gs-3446	834	7	gabunia	gabunia	NOUN
gs-3446	834	8	,	,	PUNCT
gs-3446	834	9	l.	l.	PROPN
gs-3446	834	10	.	.	PROPN
gs-3446	834	11	,	,	PUNCT
gs-3446	834	12	chichoyan	chichoyan	PROPN
gs-3446	834	13	,	,	PUNCT
gs-3446	834	14	n.	n.	PROPN
gs-3446	834	15	.	.	PUNCT
gs-3446	834	16	,	,	PUNCT
gs-3446	834	17	giorgobiani	giorgobiani	PROPN
gs-3446	834	18	,	,	PUNCT
gs-3446	834	19	m.	m.	NOUN
gs-3446	834	20	.	.	PUNCT
gs-3446	835	1	,	,	PUNCT
gs-3446	835	2	…	…	PUNCT
gs-3446	835	3	zarnadze	zarnadze	INTJ
gs-3446	835	4	,	,	PUNCT
gs-3446	835	5	s.	s.	PROPN
gs-3446	835	6	(	(	PUNCT
gs-3446	835	7	davit	davit	PROPN
gs-3446	835	8	)	)	PUNCT
gs-3446	835	9	.	.	PUNCT
gs-3446	836	1	(	(	PUNCT
gs-3446	836	2	2022	2022	NUM
gs-3446	836	3	)	)	PUNCT
gs-3446	836	4	.	.	PUNCT
gs-3446	837	1	the	the	DET
gs-3446	837	2	scientific	scientific	ADJ
gs-3446	837	3	talks	talk	NOUN
gs-3446	837	4	of	of	ADP
gs-3446	837	5	essential	essential	ADJ
gs-3446	837	6	issue	issue	NOUN
gs-3446	837	7	,	,	PUNCT
gs-3446	837	8	invocation	invocation	NOUN
gs-3446	837	9	,	,	PUNCT
gs-3446	837	10	perspectives	perspective	NOUN
gs-3446	837	11	,	,	PUNCT
gs-3446	837	12	inclinations	inclination	NOUN
gs-3446	837	13	and	and	CCONJ
gs-3446	837	14	features	feature	NOUN
gs-3446	837	15	of	of	ADP
gs-3446	837	16	the	the	DET
gs-3446	837	17	clinical	clinical	ADJ
gs-3446	837	18	pharmacists	pharmacist	NOUN
gs-3446	837	19	globally	globally	ADV
gs-3446	837	20	.	.	PUNCT
gs-3446	838	1	experimental	experimental	ADJ
gs-3446	838	2	and	and	CCONJ
gs-3446	838	3	clinical	clinical	ADJ
gs-3446	838	4	medicine	medicine	NOUN
gs-3446	838	5	georgia	georgia	PROPN
gs-3446	838	6	,	,	PUNCT
gs-3446	838	7	(	(	PUNCT
gs-3446	838	8	7	7	NUM
gs-3446	838	9	)	)	PUNCT
gs-3446	838	10	.	.	PUNCT
gs-3446	839	1	34	34	NUM
gs-3446	839	2	.	.	PUNCT
gs-3446	839	3	sulashvili	sulashvili	NOUN
gs-3446	839	4	,	,	PUNCT
gs-3446	839	5	n.	n.	NOUN
gs-3446	839	6	,	,	PUNCT
gs-3446	839	7	beglaryan	beglaryan	ADJ
gs-3446	839	8	,	,	PUNCT
gs-3446	839	9	m.	m.	NOUN
gs-3446	839	10	,	,	PUNCT
gs-3446	839	11	gorgaslidze	gorgaslidze	PROPN
gs-3446	839	12	,	,	PUNCT
gs-3446	839	13	n.	n.	PROPN
gs-3446	839	14	,	,	PUNCT
gs-3446	839	15	kocharyan	kocharyan	PROPN
gs-3446	839	16	,	,	PUNCT
gs-3446	839	17	s.	s.	PROPN
gs-3446	839	18	,	,	PUNCT
gs-3446	839	19	chichoyan	chichoyan	PROPN
gs-3446	839	20	,	,	PUNCT
gs-3446	839	21	n.	n.	NOUN
gs-3446	839	22	,	,	PUNCT
gs-3446	839	23	gabunia	gabunia	NOUN
gs-3446	839	24	,	,	PUNCT
gs-3446	839	25	l.	l.	PROPN
gs-3446	839	26	,	,	PUNCT
gs-3446	839	27	…	…	PUNCT
gs-3446	839	28	zarnadze	zarnadze	PROPN
gs-3446	839	29	,	,	PUNCT
gs-3446	839	30	s.	s.	PROPN
gs-3446	839	31	(	(	PUNCT
gs-3446	839	32	davit	davit	PROPN
gs-3446	839	33	)	)	PUNCT
gs-3446	839	34	.	.	PUNCT
gs-3446	840	1	(	(	PUNCT
gs-3446	840	2	2023	2023	NUM
gs-3446	840	3	)	)	PUNCT
gs-3446	840	4	.	.	PUNCT
gs-3446	841	1	the	the	DET
gs-3446	841	2	disclosure	disclosure	NOUN
gs-3446	841	3	of	of	ADP
gs-3446	841	4	features	feature	NOUN
gs-3446	841	5	,	,	PUNCT
gs-3446	841	6	characteristics	characteristic	NOUN
gs-3446	841	7	,	,	PUNCT
gs-3446	841	8	possibilities	possibility	NOUN
gs-3446	841	9	and	and	CCONJ
gs-3446	841	10	specialties	specialty	NOUN
gs-3446	841	11	of	of	ADP
gs-3446	841	12	clinical	clinical	ADJ
gs-3446	841	13	pharmacists	pharmacist	NOUN
gs-3446	841	14	as	as	ADP
gs-3446	841	15	mediator	mediator	NOUN
gs-3446	841	16	among	among	ADP
gs-3446	841	17	doctors	doctor	NOUN
gs-3446	841	18	and	and	CCONJ
gs-3446	841	19	patients	patient	NOUN
gs-3446	841	20	for	for	ADP
gs-3446	841	21	enhancement	enhancement	NOUN
gs-3446	841	22	public	public	ADJ
gs-3446	841	23	health	health	NOUN
gs-3446	841	24	sector	sector	NOUN
gs-3446	841	25	in	in	ADP
gs-3446	841	26	a	a	DET
gs-3446	841	27	global	global	ADJ
gs-3446	841	28	world	world	NOUN
gs-3446	841	29	.	.	PUNCT
gs-3446	842	1	experimental	experimental	ADJ
gs-3446	842	2	and	and	CCONJ
gs-3446	842	3	clinical	clinical	ADJ
gs-3446	842	4	medicine	medicine	NOUN
gs-3446	842	5	georgia	georgia	PROPN
gs-3446	842	6	,	,	PUNCT
gs-3446	842	7	(	(	PUNCT
gs-3446	842	8	4	4	NUM
gs-3446	842	9	)	)	PUNCT
gs-3446	842	10	,	,	PUNCT
gs-3446	842	11	57–62	57–62	NUM
gs-3446	842	12	.	.	PUNCT
gs-3446	843	1	https://doi.org/10.52340/jecm.2023.04.15	https://doi.org/10.52340/jecm.2023.04.15	PROPN
gs-3446	843	2	35	35	NUM
gs-3446	843	3	.	.	PUNCT
gs-3446	843	4	sulashvili	sulashvili	NOUN
gs-3446	843	5	,	,	PUNCT
gs-3446	843	6	n.	n.	NOUN
gs-3446	843	7	,	,	PUNCT
gs-3446	843	8	gorgaslidze	gorgaslidze	PROPN
gs-3446	843	9	,	,	PUNCT
gs-3446	843	10	n.	n.	NOUN
gs-3446	843	11	,	,	PUNCT
gs-3446	843	12	gabunia	gabunia	NOUN
gs-3446	843	13	,	,	PUNCT
gs-3446	843	14	l.	l.	PROPN
gs-3446	843	15	,	,	PUNCT
gs-3446	843	16	giorgobiani	giorgobiani	PROPN
gs-3446	843	17	,	,	PUNCT
gs-3446	843	18	m.	m.	NOUN
gs-3446	843	19	,	,	PUNCT
gs-3446	843	20	&	&	CCONJ
gs-3446	843	21	ratiani	ratiani	PROPN
gs-3446	843	22	,	,	PUNCT
gs-3446	843	23	l.	l.	PROPN
gs-3446	843	24	(	(	PUNCT
gs-3446	843	25	2023	2023	NUM
gs-3446	843	26	)	)	PUNCT
gs-3446	843	27	.	.	PUNCT
gs-3446	844	1	manifestation	manifestation	NOUN
gs-3446	844	2	of	of	ADP
gs-3446	844	3	the	the	DET
gs-3446	844	4	particularities	particularity	NOUN
gs-3446	844	5	of	of	ADP
gs-3446	844	6	the	the	DET
gs-3446	844	7	usage	usage	NOUN
gs-3446	844	8	features	feature	NOUN
gs-3446	844	9	of	of	ADP
gs-3446	844	10	monoclonal	monoclonal	NOUN
gs-3446	844	11	antibodies	antibody	NOUN
gs-3446	844	12	in	in	ADP
gs-3446	844	13	various	various	ADJ
gs-3446	844	14	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-3446	844	15	applications	application	NOUN
gs-3446	844	16	.	.	PUNCT
gs-3446	845	1	experimental	experimental	ADJ
gs-3446	845	2	and	and	CCONJ
gs-3446	845	3	clinical	clinical	ADJ
gs-3446	845	4	medicine	medicine	NOUN
gs-3446	845	5	georgia	georgia	PROPN
gs-3446	845	6	,	,	PUNCT
gs-3446	845	7	(	(	PUNCT
gs-3446	845	8	4	4	NUM
gs-3446	845	9	)	)	PUNCT
gs-3446	845	10	,	,	PUNCT
gs-3446	845	11	52–57	52–57	NUM
gs-3446	845	12	.	.	PUNCT
gs-3446	846	1	36	36	NUM
gs-3446	846	2	.	.	PUNCT
gs-3446	846	3	sulashvili	sulashvili	NOUN
gs-3446	846	4	,	,	PUNCT
gs-3446	846	5	n.	n.	NOUN
gs-3446	846	6	,	,	PUNCT
gs-3446	846	7	davitashvili	davitashvili	ADJ
gs-3446	846	8	,	,	PUNCT
gs-3446	846	9	m.	m.	NOUN
gs-3446	846	10	,	,	PUNCT
gs-3446	846	11	gorgaslidze	gorgaslidze	PROPN
gs-3446	846	12	,	,	PUNCT
gs-3446	846	13	n.	n.	NOUN
gs-3446	846	14	,	,	PUNCT
gs-3446	846	15	gabunia	gabunia	NOUN
gs-3446	846	16	,	,	PUNCT
gs-3446	846	17	l.	l.	PROPN
gs-3446	846	18	,	,	PUNCT
gs-3446	846	19	beglaryan	beglaryan	ADJ
gs-3446	846	20	,	,	PUNCT
gs-3446	846	21	m.	m.	NOUN
gs-3446	846	22	,	,	PUNCT
gs-3446	846	23	alavidze	alavidze	NOUN
gs-3446	846	24	,	,	PUNCT
gs-3446	846	25	n.	n.	NOUN
gs-3446	846	26	,	,	PUNCT
gs-3446	846	27	sulashvili	sulashvili	NOUN
gs-3446	846	28	,	,	PUNCT
gs-3446	846	29	m.	m.	NOUN
gs-3446	846	30	(	(	PUNCT
gs-3446	846	31	2024	2024	NUM
gs-3446	846	32	)	)	PUNCT
gs-3446	846	33	.	.	PUNCT
gs-3446	847	1	the	the	DET
gs-3446	847	2	scientific	scientific	ADJ
gs-3446	847	3	discussion	discussion	NOUN
gs-3446	847	4	of	of	ADP
gs-3446	847	5	some	some	DET
gs-3446	847	6	issues	issue	NOUN
gs-3446	847	7	of	of	ADP
gs-3446	847	8	features	feature	NOUN
gs-3446	847	9	and	and	CCONJ
gs-3446	847	10	challenges	challenge	NOUN
gs-3446	847	11	of	of	ADP
gs-3446	847	12	using	use	VERB
gs-3446	847	13	of	of	ADP
gs-3446	847	14	car	car	NOUN
gs-3446	847	15	-	-	PUNCT
gs-3446	847	16	t	t	NOUN
gs-3446	847	17	cells	cell	NOUN
gs-3446	847	18	in	in	ADP
gs-3446	847	19	immunotherapy	immunotherapy	NOUN
gs-3446	847	20	.	.	PUNCT
gs-3446	848	1	georgian	georgian	ADJ
gs-3446	848	2	scientists	scientist	NOUN
gs-3446	848	3	,	,	PUNCT
gs-3446	848	4	6(4	6(4	NOUN
gs-3446	848	5	)	)	PUNCT
gs-3446	848	6	,	,	PUNCT
gs-3446	848	7	263–290	263–290	NUM
gs-3446	848	8	.	.	PUNCT
gs-3446	849	1	https://doi.org/10.52340/gs.2024.06.04.24	https://doi.org/10.52340/gs.2024.06.04.24	PROPN
gs-3446	849	2	37	37	NUM
gs-3446	849	3	.	.	PUNCT
gs-3446	850	1	sulashvili	sulashvili	NOUN
gs-3446	850	2	,	,	PUNCT
gs-3446	850	3	n.	n.	NOUN
gs-3446	850	4	,	,	PUNCT
gs-3446	850	5	gorgaslidze	gorgaslidze	PROPN
gs-3446	850	6	,	,	PUNCT
gs-3446	850	7	n.	n.	NOUN
gs-3446	850	8	,	,	PUNCT
gs-3446	850	9	gabunia	gabunia	NOUN
gs-3446	850	10	,	,	PUNCT
gs-3446	850	11	l.	l.	PROPN
gs-3446	850	12	,	,	PUNCT
gs-3446	850	13	giorgobiani	giorgobiani	PROPN
gs-3446	850	14	,	,	PUNCT
gs-3446	850	15	m.	m.	NOUN
gs-3446	850	16	,	,	PUNCT
gs-3446	850	17	&	&	CCONJ
gs-3446	850	18	ratiani	ratiani	PROPN
gs-3446	850	19	,	,	PUNCT
gs-3446	850	20	l.	l.	PROPN
gs-3446	850	21	(	(	PUNCT
gs-3446	850	22	2023	2023	NUM
gs-3446	850	23	)	)	PUNCT
gs-3446	850	24	.	.	PUNCT
gs-3446	851	1	manifestation	manifestation	NOUN
gs-3446	851	2	of	of	ADP
gs-3446	851	3	the	the	DET
gs-3446	851	4	particularities	particularity	NOUN
gs-3446	851	5	of	of	ADP
gs-3446	851	6	the	the	DET
gs-3446	851	7	usage	usage	NOUN
gs-3446	851	8	features	feature	NOUN
gs-3446	851	9	of	of	ADP
gs-3446	851	10	monoclonal	monoclonal	NOUN
gs-3446	851	11	antibodies	antibody	NOUN
gs-3446	851	12	in	in	ADP
gs-3446	851	13	various	various	ADJ
gs-3446	851	14	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-3446	851	15	applications	application	NOUN
gs-3446	851	16	.	.	PUNCT
gs-3446	852	1	experimental	experimental	ADJ
gs-3446	852	2	and	and	CCONJ
gs-3446	852	3	clinical	clinical	ADJ
gs-3446	852	4	medicine	medicine	NOUN
gs-3446	852	5	georgia	georgia	PROPN
gs-3446	852	6	,	,	PUNCT
gs-3446	852	7	(	(	PUNCT
gs-3446	852	8	4	4	NUM
gs-3446	852	9	)	)	PUNCT
gs-3446	852	10	,	,	PUNCT
gs-3446	852	11	52–57	52–57	NUM
gs-3446	852	12	.	.	PUNCT
gs-3446	853	1	https://doi.org/10.52340/jecm.2023.04.14	https://doi.org/10.52340/jecm.2023.04.14	X
gs-3446	854	1	38	38	NUM
gs-3446	854	2	.	.	PUNCT
gs-3446	854	3	sulashvili	sulashvili	NOUN
gs-3446	854	4	,	,	PUNCT
gs-3446	854	5	n.	n.	NOUN
gs-3446	854	6	,	,	PUNCT
gs-3446	854	7	gorgaslidze	gorgaslidze	PROPN
gs-3446	854	8	,	,	PUNCT
gs-3446	854	9	n.	n.	NOUN
gs-3446	854	10	,	,	PUNCT
gs-3446	854	11	gabunia	gabunia	NOUN
gs-3446	854	12	,	,	PUNCT
gs-3446	854	13	l.	l.	PROPN
gs-3446	854	14	,	,	PUNCT
gs-3446	854	15	ratiani	ratiani	PROPN
gs-3446	854	16	,	,	PUNCT
gs-3446	854	17	l.	l.	PROPN
gs-3446	854	18	,	,	PUNCT
gs-3446	854	19	khetsuriani	khetsuriani	PROPN
gs-3446	854	20	,	,	PUNCT
gs-3446	854	21	s.	s.	PROPN
gs-3446	854	22	,	,	PUNCT
gs-3446	854	23	kravchenko	kravchenko	PROPN
gs-3446	854	24	,	,	PUNCT
gs-3446	854	25	v.	v.	NOUN
gs-3446	854	26	,	,	PUNCT
gs-3446	854	27	sulashvili	sulashvili	NOUN
gs-3446	854	28	,	,	PUNCT
gs-3446	854	29	m.	m.	NOUN
gs-3446	854	30	(	(	PUNCT
gs-3446	854	31	2024	2024	NUM
gs-3446	854	32	)	)	PUNCT
gs-3446	854	33	.	.	PUNCT
gs-3446	855	1	manifestation	manifestation	NOUN
gs-3446	855	2	of	of	ADP
gs-3446	855	3	the	the	DET
gs-3446	855	4	particularities	particularity	NOUN
gs-3446	855	5	of	of	ADP
gs-3446	855	6	some	some	DET
gs-3446	855	7	key	key	ADJ
gs-3446	855	8	issue	issue	NOUN
gs-3446	855	9	aspects	aspect	NOUN
gs-3446	855	10	of	of	ADP
gs-3446	855	11	new	new	ADJ
gs-3446	855	12	immunotherapy	immunotherapy	NOUN
gs-3446	855	13	challenges	challenge	NOUN
gs-3446	855	14	and	and	CCONJ
gs-3446	855	15	perspectives	perspective	NOUN
gs-3446	855	16	by	by	ADP
gs-3446	855	17	car	car	NOUN
gs-3446	855	18	-	-	PUNCT
gs-3446	855	19	t	t	NOUN
gs-3446	855	20	cell	cell	NOUN
gs-3446	855	21	therapy	therapy	NOUN
gs-3446	855	22	.	.	PUNCT
gs-3446	856	1	experimental	experimental	ADJ
gs-3446	856	2	and	and	CCONJ
gs-3446	856	3	clinical	clinical	ADJ
gs-3446	856	4	medicine	medicine	NOUN
gs-3446	856	5	georgia	georgia	PROPN
gs-3446	856	6	,	,	PUNCT
gs-3446	856	7	(	(	PUNCT
gs-3446	856	8	4	4	NUM
gs-3446	856	9	)	)	PUNCT
gs-3446	856	10	,	,	PUNCT
gs-3446	856	11	119–121	119–121	NUM
gs-3446	856	12	.	.	PUNCT
gs-3446	856	13	https://doi.org/10.52340/jecm.2024.04.32	https://doi.org/10.52340/jecm.2024.04.32	NUM
gs-3446	856	14	.	.	NOUN
gs-3446	856	15	39	39	NUM
gs-3446	856	16	.	.	PUNCT
gs-3446	857	1	swain	swain	PROPN
gs-3446	857	2	,	,	PUNCT
gs-3446	857	3	n.	n.	PROPN
gs-3446	857	4	,	,	PUNCT
gs-3446	857	5	thakur	thakur	PROPN
gs-3446	857	6	,	,	PUNCT
gs-3446	857	7	m.	m.	NOUN
gs-3446	857	8	,	,	PUNCT
gs-3446	857	9	pathak	pathak	PROPN
gs-3446	857	10	,	,	PUNCT
gs-3446	857	11	j.	j.	PROPN
gs-3446	857	12	,	,	PUNCT
gs-3446	857	13	&	&	CCONJ
gs-3446	857	14	swain	swain	PROPN
gs-3446	857	15	,	,	PUNCT
gs-3446	857	16	b.	b.	PROPN
gs-3446	857	17	(	(	PUNCT
gs-3446	857	18	2020	2020	NUM
gs-3446	857	19	)	)	PUNCT
gs-3446	857	20	.	.	PUNCT
gs-3446	858	1	sox2	sox2	NOUN
gs-3446	858	2	,	,	PUNCT
gs-3446	858	3	oct4	oct4	PROPN
gs-3446	858	4	and	and	CCONJ
gs-3446	858	5	nanog	nanog	PROPN
gs-3446	858	6	:	:	PUNCT
gs-3446	858	7	the	the	DET
gs-3446	858	8	core	core	ADJ
gs-3446	858	9	embryonic	embryonic	ADJ
gs-3446	858	10	stem	stem	NOUN
gs-3446	858	11	cell	cell	NOUN
gs-3446	858	12	pluripotency	pluripotency	NOUN
gs-3446	858	13	regulators	regulator	NOUN
gs-3446	858	14	in	in	ADP
gs-3446	858	15	oral	oral	ADJ
gs-3446	858	16	carcinogenesis	carcinogenesis	NOUN
gs-3446	858	17	.	.	PUNCT
gs-3446	859	1	journal	journal	NOUN
gs-3446	859	2	of	of	ADP
gs-3446	859	3	oral	oral	ADJ
gs-3446	859	4	and	and	CCONJ
gs-3446	859	5	maxillofacial	maxillofacial	ADJ
gs-3446	859	6	pathology	pathology	NOUN
gs-3446	859	7	,	,	PUNCT
gs-3446	859	8	24(2	24(2	NUM
gs-3446	859	9	)	)	PUNCT
gs-3446	859	10	,	,	PUNCT
gs-3446	859	11	368–373	368–373	NUM
gs-3446	859	12	.	.	NOUN
gs-3446	859	13	https://doi.org/10.4103/jomfp.jomfp_84_20	https://doi.org/10.4103/jomfp.jomfp_84_20	PROPN
gs-3446	859	14	40	40	NUM
gs-3446	859	15	.	.	PUNCT
gs-3446	860	1	tkemaladze	tkemaladze	PROPN
gs-3446	860	2	,	,	PUNCT
gs-3446	860	3	j.	j.	PROPN
gs-3446	860	4	(	(	PUNCT
gs-3446	860	5	2023	2023	NUM
gs-3446	860	6	)	)	PUNCT
gs-3446	860	7	.	.	PUNCT
gs-3446	861	1	reduction	reduction	NOUN
gs-3446	861	2	,	,	PUNCT
gs-3446	861	3	proliferation	proliferation	NOUN
gs-3446	861	4	,	,	PUNCT
gs-3446	861	5	and	and	CCONJ
gs-3446	861	6	differentiation	differentiation	NOUN
gs-3446	861	7	defects	defect	NOUN
gs-3446	861	8	of	of	ADP
gs-3446	861	9	stem	stem	NOUN
gs-3446	861	10	cells	cell	NOUN
gs-3446	861	11	over	over	ADP
gs-3446	861	12	time	time	NOUN
gs-3446	861	13	:	:	PUNCT
gs-3446	861	14	a	a	DET
gs-3446	861	15	consequence	consequence	NOUN
gs-3446	861	16	of	of	ADP
gs-3446	861	17	selective	selective	ADJ
gs-3446	861	18	accumulation	accumulation	NOUN
gs-3446	861	19	of	of	ADP
gs-3446	861	20	old	old	ADJ
gs-3446	861	21	centrioles	centriole	NOUN
gs-3446	861	22	in	in	ADP
gs-3446	861	23	the	the	DET
gs-3446	861	24	stem	stem	NOUN
gs-3446	861	25	cells	cell	NOUN
gs-3446	861	26	?	?	PUNCT
gs-3446	862	1	molecular	molecular	ADJ
gs-3446	862	2	biology	biology	NOUN
gs-3446	862	3	reports	report	NOUN
gs-3446	862	4	,	,	PUNCT
gs-3446	862	5	50(3	50(3	NUM
gs-3446	862	6	)	)	PUNCT
gs-3446	862	7	,	,	PUNCT
gs-3446	862	8	2751–2761	2751–2761	NUM
gs-3446	862	9	.	.	PUNCT
gs-3446	863	1	https://doi.org/10.1007/s11033-022-08221-3	https://doi.org/10.1007/s11033-022-08221-3	NUM
gs-3446	863	2	41	41	NUM
gs-3446	863	3	.	.	PUNCT
gs-3446	864	1	tkemaladze	tkemaladze	PROPN
gs-3446	864	2	,	,	PUNCT
gs-3446	864	3	j.	j.	PROPN
gs-3446	864	4	(	(	PUNCT
gs-3446	864	5	2024	2024	NUM
gs-3446	864	6	)	)	PUNCT
gs-3446	864	7	.	.	PUNCT
gs-3446	865	1	editorial	editorial	NOUN
gs-3446	865	2	:	:	PUNCT
gs-3446	865	3	molecular	molecular	ADJ
gs-3446	865	4	mechanism	mechanism	NOUN
gs-3446	865	5	of	of	ADP
gs-3446	865	6	ageing	age	VERB
gs-3446	865	7	and	and	CCONJ
gs-3446	865	8	therapeutic	therapeutic	ADJ
gs-3446	865	9	advances	advance	NOUN
gs-3446	865	10	through	through	ADP
gs-3446	865	11	targeting	target	VERB
gs-3446	865	12	glycative	glycative	ADJ
gs-3446	865	13	and	and	CCONJ
gs-3446	865	14	oxidative	oxidative	ADJ
gs-3446	865	15	stress	stress	NOUN
gs-3446	865	16	.	.	PUNCT
gs-3446	866	1	front	front	ADJ
gs-3446	866	2	pharmacol	pharmacol	PROPN
gs-3446	866	3	.	.	PUNCT
gs-3446	867	1	2024	2024	NUM
gs-3446	867	2	mar	mar	PROPN
gs-3446	867	3	6;14:1324446	6;14:1324446	PROPN
gs-3446	867	4	.	.	PUNCT
gs-3446	867	5	doi	doi	NOUN
gs-3446	867	6	:	:	PUNCT
gs-3446	867	7	10.3389	10.3389	NUM
gs-3446	867	8	/	/	SYM
gs-3446	867	9	fphar.2023.1324446	fphar.2023.1324446	NOUN
gs-3446	867	10	.	.	PUNCT
gs-3446	868	1	pmid	pmid	NOUN
gs-3446	868	2	:	:	PUNCT
gs-3446	868	3	38510429	38510429	NUM
gs-3446	868	4	;	;	PUNCT
gs-3446	868	5	pmcid	pmcid	ADJ
gs-3446	868	6	:	:	PUNCT
gs-3446	868	7	pmc10953819	pmc10953819	NOUN
gs-3446	868	8	.	.	PUNCT
gs-3446	869	1	georgian	georgian	ADJ
gs-3446	869	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	869	3	მეცნიერები	მეცნიერები	NOUN
gs-3446	869	4	ტ.	ტ.	VERB
gs-3446	869	5	7	7	NUM
gs-3446	869	6	n	n	PRON
gs-3446	869	7	1	1	NUM
gs-3446	869	8	,	,	PUNCT
gs-3446	869	9	2025	2025	NUM
gs-3446	869	10	318	318	NUM
gs-3446	869	11	42	42	NUM
gs-3446	869	12	.	.	PUNCT
gs-3446	870	1	tkemaladze	tkemaladze	PROPN
gs-3446	870	2	,	,	PUNCT
gs-3446	870	3	j.	j.	PROPN
gs-3446	870	4	v.	v.	PROPN
gs-3446	870	5	,	,	PUNCT
gs-3446	870	6	&	&	CCONJ
gs-3446	870	7	chichinadze	chichinadze	PROPN
gs-3446	870	8	,	,	PUNCT
gs-3446	870	9	k.	k.	PROPN
gs-3446	870	10	n.	n.	PROPN
gs-3446	870	11	(	(	PUNCT
gs-3446	870	12	2005	2005	NUM
gs-3446	870	13	)	)	PUNCT
gs-3446	870	14	.	.	PUNCT
gs-3446	871	1	centriolar	centriolar	ADJ
gs-3446	871	2	mechanisms	mechanism	NOUN
gs-3446	871	3	of	of	ADP
gs-3446	871	4	differentiation	differentiation	NOUN
gs-3446	871	5	and	and	CCONJ
gs-3446	871	6	replicative	replicative	ADJ
gs-3446	871	7	aging	aging	NOUN
gs-3446	871	8	of	of	ADP
gs-3446	871	9	higher	high	ADJ
gs-3446	871	10	animal	animal	NOUN
gs-3446	871	11	cells	cell	NOUN
gs-3446	871	12	.	.	PUNCT
gs-3446	872	1	biochemistry	biochemistry	NOUN
gs-3446	872	2	(	(	PUNCT
gs-3446	872	3	moscow	moscow	PROPN
gs-3446	872	4	)	)	PUNCT
gs-3446	872	5	,	,	PUNCT
gs-3446	872	6	70(12	70(12	NUM
gs-3446	872	7	)	)	PUNCT
gs-3446	872	8	,	,	PUNCT
gs-3446	872	9	1288–1303	1288–1303	NUM
gs-3446	872	10	.	.	PUNCT
gs-3446	872	11	https://doi.org/10.1007/s10541-005-0266-1	https://doi.org/10.1007/s10541-005-0266-1	PROPN
gs-3446	872	12	tkemaladze	tkemaladze	NOUN
gs-3446	872	13	j.	j.	PROPN
gs-3446	872	14	(	(	PUNCT
gs-3446	872	15	2024	2024	NUM
gs-3446	872	16	)	)	PUNCT
gs-3446	872	17	.	.	PUNCT
gs-3446	873	1	editorial	editorial	NOUN
gs-3446	873	2	:	:	PUNCT
gs-3446	873	3	molecular	molecular	ADJ
gs-3446	873	4	mechanism	mechanism	NOUN
gs-3446	873	5	of	of	ADP
gs-3446	873	6	ageing	age	VERB
gs-3446	873	7	and	and	CCONJ
gs-3446	873	8	therapeutic	therapeutic	ADJ
gs-3446	873	9	advances	advance	NOUN
gs-3446	873	10	through	through	ADP
gs-3446	873	11	targeting	target	VERB
gs-3446	873	12	glycative	glycative	ADJ
gs-3446	873	13	and	and	CCONJ
gs-3446	873	14	oxidative	oxidative	ADJ
gs-3446	873	15	stress	stress	NOUN
gs-3446	873	16	.	.	PUNCT
gs-3446	874	1	front	front	ADJ
gs-3446	874	2	pharmacol	pharmacol	PROPN
gs-3446	874	3	.	.	PUNCT
gs-3446	875	1	2024	2024	NUM
gs-3446	875	2	mar	mar	PROPN
gs-3446	875	3	6;14:1324446	6;14:1324446	PROPN
gs-3446	875	4	.	.	PUNCT
gs-3446	875	5	doi	doi	NOUN
gs-3446	875	6	:	:	PUNCT
gs-3446	875	7	10.3389	10.3389	NUM
gs-3446	875	8	/	/	SYM
gs-3446	875	9	fphar.2023.1324446	fphar.2023.1324446	NOUN
gs-3446	875	10	.	.	PUNCT
gs-3446	876	1	pmid	pmid	NOUN
gs-3446	876	2	:	:	PUNCT
gs-3446	876	3	38510429	38510429	NUM
gs-3446	876	4	;	;	PUNCT
gs-3446	876	5	pmcid	pmcid	ADJ
gs-3446	876	6	:	:	PUNCT
gs-3446	876	7	pmc10953819	pmc10953819	NOUN
gs-3446	876	8	.	.	PUNCT
gs-3446	877	1	43	43	NUM
gs-3446	877	2	.	.	PUNCT
gs-3446	877	3	tkemaladze	tkemaladze	PROPN
gs-3446	877	4	,	,	PUNCT
gs-3446	877	5	j.	j.	PROPN
gs-3446	877	6	,	,	PUNCT
gs-3446	877	7	&	&	CCONJ
gs-3446	877	8	apkhazava	apkhazava	PROPN
gs-3446	877	9	,	,	PUNCT
gs-3446	877	10	d.	d.	PROPN
gs-3446	877	11	(	(	PUNCT
gs-3446	877	12	2019	2019	NUM
gs-3446	877	13	)	)	PUNCT
gs-3446	877	14	.	.	PUNCT
gs-3446	878	1	dasatinib	dasatinib	NOUN
gs-3446	878	2	and	and	CCONJ
gs-3446	878	3	quercetin	quercetin	NOUN
gs-3446	878	4	:	:	PUNCT
gs-3446	878	5	short	short	ADJ
gs-3446	878	6	-	-	PUNCT
gs-3446	878	7	term	term	NOUN
gs-3446	878	8	simultaneous	simultaneous	ADJ
gs-3446	878	9	administration	administration	NOUN
gs-3446	878	10	improves	improve	VERB
gs-3446	878	11	physical	physical	ADJ
gs-3446	878	12	capacity	capacity	NOUN
gs-3446	878	13	in	in	ADP
gs-3446	878	14	human	human	PROPN
gs-3446	878	15	.	.	PUNCT
gs-3446	879	1	journal	journal	PROPN
gs-3446	879	2	of	of	ADP
gs-3446	879	3	biomedical	biomedical	ADJ
gs-3446	879	4	science	science	NOUN
gs-3446	879	5	,	,	PUNCT
gs-3446	879	6	8(3	8(3	NUM
gs-3446	879	7	)	)	PUNCT
gs-3446	879	8	,	,	PUNCT
gs-3446	879	9	3	3	X
gs-3446	879	10	.	.	X
gs-3446	879	11	https://doi.org/10.24966/bs-3935/100003	https://doi.org/10.24966/bs-3935/100003	PROPN
gs-3446	879	12	44	44	NUM
gs-3446	879	13	.	.	PUNCT
gs-3446	880	1	trounson	trounson	NOUN
gs-3446	880	2	,	,	PUNCT
gs-3446	880	3	a.	a.	PROPN
gs-3446	880	4	,	,	PUNCT
gs-3446	880	5	&	&	CCONJ
gs-3446	880	6	mcdonald	mcdonald	PROPN
gs-3446	880	7	,	,	PUNCT
gs-3446	880	8	c.	c.	PROPN
gs-3446	880	9	(	(	PUNCT
gs-3446	880	10	2015	2015	NUM
gs-3446	880	11	)	)	PUNCT
gs-3446	880	12	.	.	PUNCT
gs-3446	881	1	stem	stem	NOUN
gs-3446	881	2	cell	cell	NOUN
gs-3446	881	3	therapies	therapy	NOUN
gs-3446	881	4	in	in	ADP
gs-3446	881	5	clinical	clinical	ADJ
gs-3446	881	6	trials	trial	NOUN
gs-3446	881	7	:	:	PUNCT
gs-3446	881	8	progress	progress	NOUN
gs-3446	881	9	and	and	CCONJ
gs-3446	881	10	challenges	challenge	NOUN
gs-3446	881	11	.	.	PUNCT
gs-3446	882	1	cell	cell	NOUN
gs-3446	882	2	stem	stem	NOUN
gs-3446	882	3	cell	cell	NOUN
gs-3446	882	4	,	,	PUNCT
gs-3446	882	5	17(1	17(1	NUM
gs-3446	882	6	)	)	PUNCT
gs-3446	882	7	,	,	PUNCT
gs-3446	882	8	11	11	NUM
gs-3446	882	9	-	-	SYM
gs-3446	882	10	22	22	NUM
gs-3446	882	11	.	.	PUNCT
gs-3446	883	1	https://doi.org/10.1016/j.stem.2015.06.007	https://doi.org/10.1016/j.stem.2015.06.007	PROPN
gs-3446	883	2	45	45	NUM
gs-3446	883	3	.	.	PUNCT
gs-3446	884	1	tuan	tuan	PROPN
gs-3446	884	2	,	,	PUNCT
gs-3446	884	3	r.	r.	PROPN
gs-3446	884	4	s.	s.	PROPN
gs-3446	884	5	,	,	PUNCT
gs-3446	884	6	boland	boland	PROPN
gs-3446	884	7	,	,	PUNCT
gs-3446	884	8	g.	g.	PROPN
gs-3446	884	9	,	,	PUNCT
gs-3446	884	10	&	&	CCONJ
gs-3446	884	11	tuli	tuli	PROPN
gs-3446	884	12	,	,	PUNCT
gs-3446	884	13	r.	r.	PROPN
gs-3446	884	14	(	(	PUNCT
gs-3446	884	15	2003	2003	NUM
gs-3446	884	16	)	)	PUNCT
gs-3446	884	17	.	.	PUNCT
gs-3446	885	1	adult	adult	NOUN
gs-3446	885	2	mesenchymal	mesenchymal	NOUN
gs-3446	885	3	stem	stem	NOUN
gs-3446	885	4	cells	cell	NOUN
gs-3446	885	5	and	and	CCONJ
gs-3446	885	6	cell	cell	NOUN
gs-3446	885	7	-	-	PUNCT
gs-3446	885	8	based	base	VERB
gs-3446	885	9	tissue	tissue	NOUN
gs-3446	885	10	engineering	engineering	NOUN
gs-3446	885	11	.	.	PUNCT
gs-3446	886	1	arthritis	arthritis	NOUN
gs-3446	886	2	research	research	PROPN
gs-3446	886	3	&	&	CCONJ
gs-3446	886	4	therapy	therapy	NOUN
gs-3446	886	5	,	,	PUNCT
gs-3446	886	6	5(1	5(1	NUM
gs-3446	886	7	)	)	PUNCT
gs-3446	886	8	,	,	PUNCT
gs-3446	886	9	32–45	32–45	NUM
gs-3446	886	10	.	.	PUNCT
gs-3446	887	1	https://doi.org/10.1186/ar614	https://doi.org/10.1186/ar614	PROPN
gs-3446	887	2	46	46	NUM
gs-3446	887	3	.	.	PUNCT
gs-3446	888	1	van	van	PROPN
gs-3446	888	2	der	der	PROPN
gs-3446	888	3	flier	flier	NOUN
gs-3446	888	4	,	,	PUNCT
gs-3446	888	5	l.	l.	PROPN
gs-3446	888	6	g.	g.	PROPN
gs-3446	888	7	,	,	PUNCT
gs-3446	888	8	&	&	CCONJ
gs-3446	888	9	clevers	clevers	PROPN
gs-3446	888	10	,	,	PUNCT
gs-3446	888	11	h.	h.	PROPN
gs-3446	888	12	(	(	PUNCT
gs-3446	888	13	2009	2009	NUM
gs-3446	888	14	)	)	PUNCT
gs-3446	888	15	.	.	PUNCT
gs-3446	889	1	stem	stem	NOUN
gs-3446	889	2	cells	cell	NOUN
gs-3446	889	3	,	,	PUNCT
gs-3446	889	4	self	self	NOUN
gs-3446	889	5	-	-	PUNCT
gs-3446	889	6	renewal	renewal	NOUN
gs-3446	889	7	,	,	PUNCT
gs-3446	889	8	and	and	CCONJ
gs-3446	889	9	differentiation	differentiation	NOUN
gs-3446	889	10	in	in	ADP
gs-3446	889	11	the	the	DET
gs-3446	889	12	intestinal	intestinal	ADJ
gs-3446	889	13	epithelium	epithelium	NOUN
gs-3446	889	14	.	.	PUNCT
gs-3446	890	1	annual	annual	ADJ
gs-3446	890	2	review	review	NOUN
gs-3446	890	3	of	of	ADP
gs-3446	890	4	physiology	physiology	NOUN
gs-3446	890	5	,	,	PUNCT
gs-3446	890	6	71	71	NUM
gs-3446	890	7	,	,	PUNCT
gs-3446	890	8	241–260	241–260	NUM
gs-3446	890	9	.	.	PUNCT
gs-3446	891	1	https://doi.org/10.1146/annurev.physiol.010908.163145	https://doi.org/10.1146/annurev.physiol.010908.163145	NOUN
gs-3446	891	2	47	47	NUM
gs-3446	891	3	.	.	PUNCT
gs-3446	892	1	vandana	vandana	PROPN
gs-3446	892	2	,	,	PUNCT
gs-3446	892	3	j.	j.	PROPN
gs-3446	892	4	j.	j.	PROPN
gs-3446	892	5	,	,	PUNCT
gs-3446	892	6	manrique	manrique	PROPN
gs-3446	892	7	,	,	PUNCT
gs-3446	892	8	c.	c.	PROPN
gs-3446	892	9	,	,	PUNCT
gs-3446	892	10	lacko	lacko	PROPN
gs-3446	892	11	,	,	PUNCT
gs-3446	892	12	l.	l.	PROPN
gs-3446	892	13	a.	a.	PROPN
gs-3446	892	14	,	,	PUNCT
gs-3446	892	15	&	&	CCONJ
gs-3446	892	16	chen	chen	PROPN
gs-3446	892	17	,	,	PUNCT
gs-3446	892	18	s.	s.	PROPN
gs-3446	892	19	(	(	PUNCT
gs-3446	892	20	2023	2023	NUM
gs-3446	892	21	)	)	PUNCT
gs-3446	892	22	.	.	PUNCT
gs-3446	893	1	human	human	ADJ
gs-3446	893	2	pluripotent	pluripotent	NOUN
gs-3446	893	3	-	-	PUNCT
gs-3446	893	4	stem	stem	NOUN
gs-3446	893	5	-	-	PUNCT
gs-3446	893	6	cellderived	cellderive	VERB
gs-3446	893	7	organoids	organoid	NOUN
gs-3446	893	8	for	for	ADP
gs-3446	893	9	drug	drug	NOUN
gs-3446	893	10	discovery	discovery	NOUN
gs-3446	893	11	and	and	CCONJ
gs-3446	893	12	evaluation	evaluation	NOUN
gs-3446	893	13	.	.	PUNCT
gs-3446	894	1	cell	cell	NOUN
gs-3446	894	2	stem	stem	NOUN
gs-3446	894	3	cell	cell	NOUN
gs-3446	894	4	,	,	PUNCT
gs-3446	894	5	30(5	30(5	NUM
gs-3446	894	6	)	)	PUNCT
gs-3446	894	7	,	,	PUNCT
gs-3446	894	8	571–591	571–591	NUM
gs-3446	894	9	.	.	PUNCT
gs-3446	895	1	https://doi.org/10.1016/j.stem.2023.04.011	https://doi.org/10.1016/j.stem.2023.04.011	ADJ
gs-3446	895	2	48	48	NUM
gs-3446	895	3	.	.	PUNCT
gs-3446	896	1	young	young	ADJ
gs-3446	896	2	,	,	PUNCT
gs-3446	896	3	r.	r.	PROPN
gs-3446	896	4	a.	a.	PROPN
gs-3446	896	5	(	(	PUNCT
gs-3446	896	6	2011	2011	NUM
gs-3446	896	7	)	)	PUNCT
gs-3446	896	8	.	.	PUNCT
gs-3446	897	1	control	control	NOUN
gs-3446	897	2	of	of	ADP
gs-3446	897	3	the	the	DET
gs-3446	897	4	embryonic	embryonic	ADJ
gs-3446	897	5	stem	stem	NOUN
gs-3446	897	6	cell	cell	NOUN
gs-3446	897	7	state	state	NOUN
gs-3446	897	8	.	.	PUNCT
gs-3446	898	1	cell	cell	NOUN
gs-3446	898	2	,	,	PUNCT
gs-3446	898	3	144(6	144(6	NUM
gs-3446	898	4	)	)	PUNCT
gs-3446	898	5	,	,	PUNCT
gs-3446	898	6	940	940	NUM
gs-3446	898	7	-	-	SYM
gs-3446	898	8	954	954	NUM
gs-3446	898	9	.	.	PUNCT
gs-3446	899	1	https://doi.org/10.1016/j.cell.2011.01.032	https://doi.org/10.1016/j.cell.2011.01.032	NUM
gs-3446	899	2	49	49	NUM
gs-3446	899	3	.	.	PUNCT
gs-3446	900	1	zare	zare	PROPN
gs-3446	900	2	,	,	PUNCT
gs-3446	900	3	a.	a.	NOUN
gs-3446	900	4	,	,	PUNCT
gs-3446	900	5	salehpour	salehpour	NOUN
gs-3446	900	6	,	,	PUNCT
gs-3446	900	7	a.	a.	NOUN
gs-3446	900	8	,	,	PUNCT
gs-3446	900	9	et	et	PROPN
gs-3446	900	10	al	al	PROPN
gs-3446	900	11	.	.	PROPN
gs-3446	900	12	(	(	PUNCT
gs-3446	900	13	2023	2023	NUM
gs-3446	900	14	)	)	PUNCT
gs-3446	900	15	.	.	PUNCT
gs-3446	901	1	epigenetic	epigenetic	ADJ
gs-3446	901	2	modification	modification	NOUN
gs-3446	901	3	factors	factor	NOUN
gs-3446	901	4	and	and	CCONJ
gs-3446	901	5	micrornas	microrna	NOUN
gs-3446	901	6	network	network	NOUN
gs-3446	901	7	associated	associate	VERB
gs-3446	901	8	with	with	ADP
gs-3446	901	9	differentiation	differentiation	NOUN
gs-3446	901	10	of	of	ADP
gs-3446	901	11	embryonic	embryonic	ADJ
gs-3446	901	12	stem	stem	NOUN
gs-3446	901	13	cells	cell	NOUN
gs-3446	901	14	and	and	CCONJ
gs-3446	901	15	induced	induce	VERB
gs-3446	901	16	pluripotent	pluripotent	ADJ
gs-3446	901	17	stem	stem	NOUN
gs-3446	901	18	cells	cell	NOUN
gs-3446	901	19	toward	toward	ADP
gs-3446	901	20	cardiomyocytes	cardiomyocyte	NOUN
gs-3446	901	21	:	:	PUNCT
gs-3446	901	22	a	a	DET
gs-3446	901	23	review	review	NOUN
gs-3446	901	24	.	.	PUNCT
gs-3446	902	1	life	life	NOUN
gs-3446	902	2	,	,	PUNCT
gs-3446	902	3	13(2	13(2	PROPN
gs-3446	902	4	)	)	PUNCT
gs-3446	902	5	,	,	PUNCT
gs-3446	902	6	569	569	X
gs-3446	902	7	.	.	PUNCT
gs-3446	903	1	https://doi.org/10.3390/life13020569	https://doi.org/10.3390/life13020569	PROPN
gs-3446	903	2	50	50	NUM
gs-3446	903	3	.	.	PUNCT
gs-3446	904	1	zhang	zhang	PROPN
gs-3446	904	2	,	,	PUNCT
gs-3446	904	3	p.	p.	PROPN
gs-3446	904	4	,	,	PUNCT
gs-3446	904	5	li	li	PROPN
gs-3446	904	6	,	,	PUNCT
gs-3446	904	7	x.	x.	PROPN
gs-3446	904	8	,	,	PUNCT
gs-3446	904	9	pan	pan	PROPN
gs-3446	904	10	,	,	PUNCT
gs-3446	904	11	c.	c.	PROPN
gs-3446	904	12	,	,	PUNCT
gs-3446	904	13	zheng	zheng	PROPN
gs-3446	904	14	,	,	PUNCT
gs-3446	904	15	x.	x.	PROPN
gs-3446	904	16	,	,	PUNCT
gs-3446	904	17	hu	hu	PROPN
gs-3446	904	18	,	,	PUNCT
gs-3446	904	19	b.	b.	PROPN
gs-3446	904	20	,	,	PUNCT
gs-3446	904	21	xie	xie	PROPN
gs-3446	904	22	,	,	PUNCT
gs-3446	904	23	r.	r.	PROPN
gs-3446	904	24	,	,	PUNCT
gs-3446	904	25	hu	hu	PROPN
gs-3446	904	26	,	,	PUNCT
gs-3446	904	27	j.	j.	PROPN
gs-3446	904	28	,	,	PUNCT
gs-3446	904	29	shang	shang	PROPN
gs-3446	904	30	,	,	PUNCT
gs-3446	904	31	x.	x.	PROPN
gs-3446	904	32	,	,	PUNCT
gs-3446	904	33	&	&	CCONJ
gs-3446	904	34	yang	yang	PROPN
gs-3446	904	35	,	,	PUNCT
gs-3446	904	36	h.	h.	PROPN
gs-3446	904	37	(	(	PUNCT
gs-3446	904	38	2022	2022	NUM
gs-3446	904	39	)	)	PUNCT
gs-3446	904	40	.	.	PUNCT
gs-3446	905	1	singlecell	singlecell	VERB
gs-3446	905	2	rna	rna	NOUN
gs-3446	905	3	sequencing	sequence	VERB
gs-3446	905	4	to	to	PART
gs-3446	905	5	track	track	VERB
gs-3446	905	6	novel	novel	ADJ
gs-3446	905	7	perspectives	perspective	NOUN
gs-3446	905	8	in	in	ADP
gs-3446	905	9	hsc	hsc	PROPN
gs-3446	905	10	heterogeneity	heterogeneity	NOUN
gs-3446	905	11	.	.	PUNCT
gs-3446	906	1	stem	stem	NOUN
gs-3446	906	2	cell	cell	NOUN
gs-3446	906	3	research	research	NOUN
gs-3446	906	4	&	&	CCONJ
gs-3446	906	5	therapy	therapy	NOUN
gs-3446	906	6	,	,	PUNCT
gs-3446	906	7	13(1	13(1	NUM
gs-3446	906	8	)	)	PUNCT
gs-3446	906	9	,	,	PUNCT
gs-3446	906	10	39	39	NUM
gs-3446	906	11	.	.	PUNCT
gs-3446	907	1	https://doi.org/10.1186/s13287-022-02717-2	https://doi.org/10.1186/s13287-022-02717-2	NUM
gs-3446	907	2	georgian	georgian	PROPN
gs-3446	907	3	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3446	907	4	მეცნიერები	მეცნიერები	NOUN
gs-3446	907	5	ტ.	ტ.	VERB
gs-3446	907	6	7	7	NUM
gs-3446	907	7	n	n	PRON
gs-3446	907	8	1	1	NUM
gs-3446	907	9	,	,	PUNCT
gs-3446	907	10	2025	2025	NUM
gs-3446	907	11	319	319	NUM
gs-3446	907	12	ღეროვანი	ღეროვანი	NOUN
gs-3446	907	13	უჯრედების	უჯრედების	PROPN
gs-3446	907	14	სისტემები	სისტემები	PROPN
gs-3446	907	15	და	და	PROPN
gs-3446	907	16	რეგენერაცია	რეგენერაცია	PROPN
gs-3446	907	17	დავით	დავით	PROPN
gs-3446	907	18	აფხაზავა1	აფხაზავა1	PROPN
gs-3446	907	19	,	,	PUNCT
gs-3446	907	20	ნოდარ	ნოდარ	PROPN
gs-3446	907	21	სულაშვილი2	სულაშვილი2	PROPN
gs-3446	907	22	,	,	PUNCT
gs-3446	907	23	ჯაბა	ჯაბა	PROPN
gs-3446	907	24	ტყემალაძე3	ტყემალაძე3	PROPN
gs-3446	908	1	1ბიოლოგიურ	1ბიოლოგიურ	NUM
gs-3446	908	2	მეცნიერებათა	მეცნიერებათა	NOUN
gs-3446	908	3	დოქტორი	დოქტორი	NOUN
gs-3446	908	4	,	,	PUNCT
gs-3446	908	5	პროფესორი	პროფესორი	ADJ
gs-3446	908	6	,	,	PUNCT
gs-3446	908	7	ალტე	ალტე	ADJ
gs-3446	908	8	უნივერსიტეტის	უნივერსიტეტის	NOUN
gs-3446	908	9	მედიცინის	მედიცინის	PRON
gs-3446	908	10	საერთაშორისო	საერთაშორისო	NOUN
gs-3446	908	11	სკოლის	სკოლის	VERB
gs-3446	908	12	ბიოქიმიის	ბიოქიმიის	PROPN
gs-3446	908	13	პროფესორი	პროფესორი	PROPN
gs-3446	908	14	,	,	PUNCT
gs-3446	908	15	თბილისი	თბილისი	PROPN
gs-3446	908	16	,	,	PUNCT
gs-3446	908	17	საქართველო	საქართველო	PROPN
gs-3446	908	18	https://orcid.org/0000-00016216-6477	https://orcid.org/0000-00016216-6477	PROPN
gs-3446	908	19	;	;	PUNCT
gs-3446	908	20	d.apkhazava@alte.edu.ge	d.apkhazava@alte.edu.ge	NOUN
gs-3446	908	21	;	;	PUNCT
gs-3446	908	22	2მედიცინის	2მედიცინის	NUM
gs-3446	908	23	დოქტორი	დოქტორი	NOUN
gs-3446	908	24	,	,	PUNCT
gs-3446	908	25	ფარმაცევტულ	ფარმაცევტულ	PROPN
gs-3446	908	26	და	და	NOUN
gs-3446	908	27	ფარმაკოლოგიურ	ფარმაკოლოგიურ	NOUN
gs-3446	908	28	მეცნიერებათა	მეცნიერებათა	NOUN
gs-3446	908	29	დოქტორი	დოქტორი	NOUN
gs-3446	908	30	,	,	PUNCT
gs-3446	908	31	პროფესორი	პროფესორი	ADJ
gs-3446	908	32	,	,	PUNCT
gs-3446	908	33	ალტე	ალტე	ADJ
gs-3446	908	34	უნივერსიტეტის	უნივერსიტეტის	NOUN
gs-3446	908	35	მედიცინის	მედიცინის	PRON
gs-3446	908	36	საერთაშორისო	საერთაშორისო	PROPN
gs-3446	908	37	სკოლის	სკოლის	PROPN
gs-3446	908	38	ფარმაკოლოგიის	ფარმაკოლოგიის	PROPN
gs-3446	908	39	პროფესორი	პროფესორი	PROPN
gs-3446	908	40	,	,	PUNCT
gs-3446	908	41	თბილისი	თბილისი	PROPN
gs-3446	908	42	,	,	PUNCT
gs-3446	908	43	საქართველო	საქართველო	PROPN
gs-3446	908	44	https://orcid.org/0000-0002-9005-8577	https://orcid.org/0000-0002-9005-8577	PROPN
gs-3446	908	45	;	;	PUNCT
gs-3446	908	46	n.sulashvili@ug.edu.ge	n.sulashvili@ug.edu.ge	PROPN
gs-3446	908	47	;	;	PUNCT
gs-3446	908	48	3კვლევების	3კვლევების	NUM
gs-3446	908	49	დირექტორი	დირექტორი	NOUN
gs-3446	908	50	,	,	PUNCT
gs-3446	908	51	დღეგრძელობის	დღეგრძელობის	ADJ
gs-3446	908	52	კლინიკა	კლინიკა	ADV
gs-3446	908	53	,	,	PUNCT
gs-3446	908	54	შოთა	შოთა	VERB
gs-3446	908	55	რუსთაველის	რუსთაველის	NOUN
gs-3446	908	56	ქ.	ქ.	NOUN
gs-3446	908	57	46	46	NUM
gs-3446	908	58	,	,	PUNCT
gs-3446	908	59	3001	3001	NUM
gs-3446	908	60	,	,	PUNCT
gs-3446	908	61	აბასთუმანი	აბასთუმანი	NOUN
gs-3446	908	62	,	,	PUNCT
gs-3446	908	63	საქართველო	საქართველო	VERB
gs-3446	908	64	https://orcid.org/0000-0001-8651-7243	https://orcid.org/0000-0001-8651-7243	PROPN
gs-3446	908	65	;	;	PUNCT
gs-3446	908	66	jtkemaladze@longevity.ge	jtkemaladze@longevity.ge	NOUN
gs-3446	908	67	აბსტრაქტი	აბსტრაქტი	NOUN
gs-3446	908	68	ღეროვანი	ღეროვანი	NOUN
gs-3446	908	69	უჯრედების	უჯრედების	VERB
gs-3446	908	70	სისტემები	სისტემები	NOUN
gs-3446	908	71	გადამწყვეტია	გადამწყვეტია	PROPN
gs-3446	908	72	ბიოლოგიურ	ბიოლოგიურ	PROPN
gs-3446	908	73	განვითარებაში	განვითარებაში	PROPN
gs-3446	908	74	,	,	PUNCT
gs-3446	908	75	ქსოვილების	ქსოვილების	PROPN
gs-3446	908	76	შენარჩუნებასა	შენარჩუნებასა	PROPN
gs-3446	908	77	და	და	PROPN
gs-3446	908	78	რეგენერაციულ	რეგენერაციულ	PROPN
gs-3446	908	79	მედიცინაში	მედიცინაში	NOUN
gs-3446	908	80	,	,	PUNCT
gs-3446	908	81	მათი	მათი	PROPN
gs-3446	908	82	თვითგანახლებისა	თვითგანახლებისა	VERB
gs-3446	908	83	და	და	PROPN
gs-3446	909	1	დიფერენციაციის	დიფერენციაციის	PROPN
gs-3446	909	2	ორმაგი	ორმაგი	NOUN
gs-3446	909	3	უნარის	უნარის	VERB
gs-3446	909	4	გამო.	გამო.	NOUN
gs-3446	909	5	ეს	ეს	NOUN
gs-3446	909	6	მიმოხილვა	მიმოხილვა	NOUN
gs-3446	909	7	იკვლევს	იკვლევს	ADJ
gs-3446	909	8	ღეროვანი	ღეროვანი	NOUN
gs-3446	909	9	უჯრედების	უჯრედების	VERB
gs-3446	909	10	ჰეტეროგენულობასა	ჰეტეროგენულობასა	NOUN
gs-3446	909	11	და	და	PROPN
gs-3446	909	12	მარეგულირებელ	მარეგულირებელ	NOUN
gs-3446	909	13	მექანიზმებს	მექანიზმებს	NOUN
gs-3446	909	14	პოტენციის	პოტენციის	PROPN
gs-3446	909	15	მდგომარეობებში	მდგომარეობებში	NOUN
gs-3446	909	16	—	—	PUNCT
gs-3446	909	17	პლურიპოტენტური	პლურიპოტენტური	PROPN
gs-3446	909	18	,	,	PUNCT
gs-3446	909	19	მულტიპოტენტური	მულტიპოტენტური	PROPN
gs-3446	909	20	და	და	NOUN
gs-3446	909	21	უნიპოტენტური	უნიპოტენტური	PROPN
gs-3446	909	22	—	—	PUNCT
gs-3446	909	23	ხაზს	ხაზს	ADJ
gs-3446	909	24	უსვამს	უსვამს	NOUN
gs-3446	909	25	დინამიკურ	დინამიკურ	PROPN
gs-3446	909	26	ტრანსკრიპციულ	ტრანსკრიპციულ	ADP
gs-3446	909	27	სქემებს	სქემებს	NOUN
gs-3446	909	28	,	,	PUNCT
gs-3446	909	29	რომლებიც	რომლებიც	VERB
gs-3446	909	30	მოიცავს	მოიცავს	VERB
gs-3446	909	31	ძირითად	ძირითად	ADJ
gs-3446	909	32	ფაქტორებს	ფაქტორებს	NOUN
gs-3446	909	33	(	(	PUNCT
gs-3446	909	34	oct4	oct4	NOUN
gs-3446	909	35	,	,	PUNCT
gs-3446	909	36	sox2	sox2	NOUN
gs-3446	909	37	,	,	PUNCT
gs-3446	909	38	nanog	nanog	PROPN
gs-3446	909	39	)	)	PUNCT
gs-3446	909	40	და	და	PROPN
gs-3446	909	41	სასიგნალო	სასიგნალო	NOUN
gs-3446	909	42	გზებს	გზებს	NOUN
gs-3446	909	43	(	(	PUNCT
gs-3446	909	44	wnt	wnt	PROPN
gs-3446	909	45	/	/	SYM
gs-3446	909	46	βcatenin	βcatenin	ADJ
gs-3446	909	47	,	,	PUNCT
gs-3446	909	48	notch	notch	ADJ
gs-3446	909	49	,	,	PUNCT
gs-3446	909	50	hedgehog	hedgehog	NOUN
gs-3446	909	51	)	)	PUNCT
gs-3446	909	52	.	.	PUNCT
gs-3446	910	1	ღეროვანი	ღეროვანი	NOUN
gs-3446	910	2	უჯრედების	უჯრედების	VERB
gs-3446	910	3	ჰომეოსტაზი	ჰომეოსტაზი	NOUN
gs-3446	910	4	,	,	PUNCT
gs-3446	910	5	რომელიც	რომელიც	ADJ
gs-3446	910	6	გადამწყვეტია	გადამწყვეტია	PROPN
gs-3446	910	7	ქსოვილის	ქსოვილის	NOUN
gs-3446	910	8	მთლიანობისთვის	მთლიანობისთვის	NOUN
gs-3446	910	9	,	,	PUNCT
gs-3446	910	10	შენარჩუნებულია	შენარჩუნებულია	VERB
gs-3446	910	11	შინაგანი	შინაგანი	NOUN
gs-3446	910	12	(	(	PUNCT
gs-3446	910	13	ეპიგენეტიკური	ეპიგენეტიკური	ADJ
gs-3446	910	14	,	,	PUNCT
gs-3446	910	15	მეტაბოლური	მეტაბოლური	ADJ
gs-3446	910	16	)	)	PUNCT
gs-3446	910	17	და	და	NOUN
gs-3446	910	18	გარეგანი	გარეგანი	NOUN
gs-3446	910	19	(	(	PUNCT
gs-3446	910	20	ნიშიდან	ნიშიდან	NOUN
gs-3446	910	21	მიღებული	მიღებული	PROPN
gs-3446	910	22	)	)	PUNCT
gs-3446	910	23	სიგნალების	სიგნალების	ADV
gs-3446	910	24	მეშვეობით	მეშვეობით	PROPN
gs-3446	910	25	,	,	PUNCT
gs-3446	910	26	რომელთა	რომელთა	PROPN
gs-3446	910	27	დარღვევები	დარღვევები	PROPN
gs-3446	910	28	დაკავშირებულია	დაკავშირებულია	VERB
gs-3446	910	29	დაბერებასთან	დაბერებასთან	ADV
gs-3446	910	30	,	,	PUNCT
gs-3446	910	31	დეგენერაციულ	დეგენერაციულ	ADJ
gs-3446	910	32	დაავადებებთან	დაავადებებთან	ADJ
gs-3446	910	33	და	და	PROPN
gs-3446	910	34	კიბოსთან.	კიბოსთან.	NOUN
gs-3446	910	35	ინდუცირებული	ინდუცირებული	VERB
gs-3446	910	36	პლურიპოტენტური	პლურიპოტენტური	PROPN
gs-3446	910	37	ღეროვანი	ღეროვანი	NOUN
gs-3446	910	38	უჯრედების	უჯრედების	NOUN
gs-3446	910	39	(	(	PUNCT
gs-3446	910	40	ipscs	ipscs	NOUN
gs-3446	910	41	)	)	PUNCT
gs-3446	910	42	და	და	NOUN
gs-3446	910	43	გენომის	გენომის	NOUN
gs-3446	910	44	რედაქტირების	რედაქტირების	PROPN
gs-3446	910	45	(	(	PUNCT
gs-3446	910	46	crispr	crispr	NOUN
gs-3446	910	47	-	-	PUNCT
gs-3446	910	48	cas9	cas9	NOUN
gs-3446	910	49	)	)	PUNCT
gs-3446	910	50	მიღწევები	მიღწევები	NOUN
gs-3446	910	51	ტრანსფორმაციულ	ტრანსფორმაციულ	VERB
gs-3446	910	52	პოტენციალს	პოტენციალს	NOUN
gs-3446	910	53	გვთავაზობს	გვთავაზობს	PROPN
gs-3446	910	54	პერსონალიზებული	პერსონალიზებული	PROPN
gs-3446	910	55	თერაპიისთვის	თერაპიისთვის	PROPN
gs-3446	910	56	,	,	PUNCT
gs-3446	910	57	თუმცა	თუმცა	VERB
gs-3446	910	58	სიმსივნური	სიმსივნური	ADJ
gs-3446	910	59	წარმოქმნის	წარმოქმნის	PROPN
gs-3446	910	60	,	,	PUNCT
gs-3446	910	61	იმუნური	იმუნური	PROPN
gs-3446	911	1	უარყოფისა	უარყოფისა	PROPN
gs-3446	911	2	და	და	PROPN
gs-3446	911	3	ეთიკური	ეთიკური	PROPN
gs-3446	911	4	საკითხების	საკითხების	PROPN
gs-3446	911	5	გამოწვევები	გამოწვევები	NOUN
gs-3446	911	6	კვლავ	კვლავ	PROPN
gs-3446	911	7	არსებობს.	არსებობს.	PROPN
gs-3446	911	8	ხაზგასმულია	ხაზგასმულია	VERB
gs-3446	911	9	ღეროვანი	ღეროვანი	NOUN
gs-3446	911	10	უჯრედების	უჯრედების	VERB
gs-3446	911	11	ნიშების	ნიშების	PROPN
gs-3446	911	12	როლი	როლი	VERB
gs-3446	911	13	მოსვენების	მოსვენების	NOUN
gs-3446	911	14	,	,	PUNCT
gs-3446	911	15	პროლიფერაციისა	პროლიფერაციისა	ADJ
gs-3446	911	16	და	და	PROPN
gs-3446	911	17	დიფერენციაციის	დიფერენციაციის	PROPN
gs-3446	911	18	მოდულირებაში	მოდულირებაში	PROPN
gs-3446	911	19	,	,	PUNCT
gs-3446	911	20	ასევე	ასევე	PROPN
gs-3446	911	21	გამოყენება	გამოყენება	PROPN
gs-3446	911	22	ქსოვილოვანი	ქსოვილოვანი	NOUN
gs-3446	911	23	ინჟინერიის	ინჟინერიის	NOUN
gs-3446	911	24	,	,	PUNCT
gs-3446	911	25	ორგანოიდების	ორგანოიდების	ADV
gs-3446	911	26	განვითარებისა	განვითარებისა	VERB
gs-3446	911	27	და	და	PROPN
gs-3446	911	28	დაავადების	დაავადების	PROPN
gs-3446	911	29	მოდელირებისთვის.	მოდელირებისთვის.	PROPN
gs-3446	911	30	დაბერებასთან	დაბერებასთან	PROPN
gs-3446	911	31	დაკავშირებული	დაკავშირებული	PROPN
gs-3446	911	32	ღეროვანი	ღეროვანი	NOUN
gs-3446	911	33	უჯრედების	უჯრედების	VERB
gs-3446	911	34	ფუნქციის	ფუნქციის	PRON
gs-3446	911	35	დაქვეითება	დაქვეითება	VERB
gs-3446	911	36	,	,	PUNCT
gs-3446	911	37	რომელიც	რომელიც	PROPN
gs-3446	911	38	გამოწვეულია	გამოწვეულია	ADJ
gs-3446	911	39	ოქსიდაციური	ოქსიდაციური	NOUN
gs-3446	911	40	სტრესით	სტრესით	NOUN
gs-3446	911	41	,	,	PUNCT
gs-3446	911	42	დნმ-ის	დნმ-ის	PROPN
gs-3446	911	43	დაზიანებით	დაზიანებით	NOUN
gs-3446	911	44	და	და	VERB
gs-3446	911	45	ეპიგენეტიკური	ეპიგენეტიკური	ADV
gs-3446	911	46	ცვლილებებით	ცვლილებებით	PROPN
gs-3446	911	47	,	,	PUNCT
gs-3446	911	48	ხაზს	ხაზს	ADJ
gs-3446	911	49	უსვამს	უსვამს	NOUN
gs-3446	911	50	გაახალგაზრდავების	გაახალგაზრდავების	VERB
gs-3446	911	51	სტრატეგიების	სტრატეგიების	NOUN
gs-3446	911	52	საჭიროებას.	საჭიროებას.	NOUN
gs-3446	911	53	გარდა	გარდა	NOUN
gs-3446	911	54	ამისა	ამისა	NOUN
gs-3446	911	55	,	,	PUNCT
gs-3446	911	56	კიბოს	კიბოს	PROPN
gs-3446	911	57	ღეროვანი	ღეროვანი	NOUN
gs-3446	911	58	უჯრედების	უჯრედების	NOUN
gs-3446	911	59	(	(	PUNCT
gs-3446	911	60	cscs	cscs	PROPN
gs-3446	911	61	)	)	PUNCT
gs-3446	911	62	დისრეგულირებული	დისრეგულირებული	VERB
gs-3446	911	63	ტრანსკრიპციული	ტრანსკრიპციული	PROPN
gs-3446	911	64	ქსელები	ქსელები	PROPN
gs-3446	911	65	წარმოადგენს	წარმოადგენს	PROPN
gs-3446	911	66	თერაპიულ	თერაპიულ	ADJ
gs-3446	911	67	სამიზნეებს	სამიზნეებს	PROPN
gs-3446	911	68	სიზუსტის	სიზუსტის	NOUN
gs-3446	911	69	ონკოლოგიისთვის.	ონკოლოგიისთვის.	PROPN
gs-3446	911	70	მომავალი	მომავალი	PROPN
gs-3446	911	71	მიმართულებები	მიმართულებები	VERB
gs-3446	911	72	ხაზს	ხაზს	ADJ
gs-3446	911	73	უსვამს	უსვამს	NOUN
gs-3446	911	74	ერთუჯრედულ	ერთუჯრედულ	ADV
gs-3446	911	75	მულტიომიკას	მულტიომიკას	PROPN
gs-3446	911	76	,	,	PUNCT
gs-3446	911	77	სინთეზურ	სინთეზურ	VERB
gs-3446	911	78	ბიოლოგიას	ბიოლოგიას	ADJ
gs-3446	911	79	და	და	PROPN
gs-3446	911	80	ბიოინჟინერიულ	ბიოინჟინერიულ	PROPN
gs-3446	911	81	ნიშებს	ნიშებს	NOUN
gs-3446	911	82	,	,	PUNCT
gs-3446	911	83	რათა	რათა	PROPN
gs-3446	911	84	დახვეწოს	დახვეწოს	NOUN
gs-3446	911	85	დიფერენციაციის	დიფერენციაციის	ADJ
gs-3446	911	86	პროტოკოლები	პროტოკოლები	ADJ
gs-3446	911	87	და	და	NOUN
gs-3446	911	88	გააუმჯობესოს	გააუმჯობესოს	ADV
gs-3446	911	89	კლინიკური	კლინიკური	NOUN
gs-3446	911	90	ტრანსლაცია.	ტრანსლაცია.	VERB
gs-3446	911	91	მოლეკულური	მოლეკულური	PROPN
gs-3446	911	92	შეხედულებების	შეხედულებების	ADJ
gs-3446	911	93	ტექნოლოგიურ	ტექნოლოგიურ	PROPN
gs-3446	911	94	ინოვაციებთან	ინოვაციებთან	NOUN
gs-3446	911	95	ინტეგრირებით	ინტეგრირებით	NOUN
gs-3446	911	96	,	,	PUNCT
gs-3446	911	97	ღეროვანი	ღეროვანი	NOUN
gs-3446	911	98	უჯრედების	უჯრედების	VERB
gs-3446	911	99	კვლევა	კვლევა	PROPN
gs-3446	911	100	გვპირდება	გვპირდება	PROPN
gs-3446	911	101	რეგენერაციული	რეგენერაციული	PROPN
gs-3446	912	1	მედიცინის	მედიცინის	DET
gs-3446	912	2	ხარვეზების	ხარვეზების	NOUN
gs-3446	912	3	შევსებას	შევსებას	NOUN
gs-3446	912	4	,	,	PUNCT
gs-3446	912	5	დეგენერაციული	დეგენერაციული	X
gs-3446	912	6	დარღვევების	დარღვევების	NOUN
gs-3446	912	7	,	,	PUNCT
gs-3446	912	8	დაზიანების	დაზიანების	NOUN
gs-3446	912	9	აღდგენისა	აღდგენისა	PROPN
gs-3446	912	10	და	და	PROPN
gs-3446	912	11	პერსონალიზებული	პერსონალიზებული	PROPN
gs-3446	912	12	ჯანდაცვისთვის	ჯანდაცვისთვის	PROPN
gs-3446	912	13	ახალი	ახალი	ADJ
gs-3446	912	14	გადაწყვეტილებების	გადაწყვეტილებების	NOUN
gs-3446	912	15	შეთავაზებას.	შეთავაზებას.	NOUN
gs-3446	912	16	საკვანძო	საკვანძო	PROPN
gs-3446	912	17	სიტყვები	სიტყვები	NOUN
gs-3446	912	18	:	:	PUNCT
gs-3446	912	19	რეგენერაცია	რეგენერაცია	PROPN
gs-3446	912	20	,	,	PUNCT
gs-3446	912	21	თვითგანახლება	თვითგანახლება	PROPN
gs-3446	912	22	,	,	PUNCT
gs-3446	912	23	ღეროვანი	ღეროვანი	NOUN
gs-3446	912	24	უჯრედები	უჯრედები	NOUN
gs-3446	912	25	,	,	PUNCT
gs-3446	912	26	ასიმეტრიული	ასიმეტრიული	PROPN
gs-3446	912	27	გაყოფა	გაყოფა	NOUN
gs-3446	912	28	,	,	PUNCT
gs-3446	912	29	სასიგნალო	სასიგნალო	NOUN
gs-3446	912	30	გზები	გზები	NOUN
gs-3446	912	31	,	,	PUNCT
gs-3446	912	32	დაბერება	დაბერება	ADJ
gs-3446	912	33	,	,	PUNCT
gs-3446	912	34	გაყოფის	გაყოფის	NOUN
gs-3446	912	35	ტემპი	ტემპი	NOUN
gs-3446	912	36	,	,	PUNCT
gs-3446	912	37	crispr	crispr	NOUN
gs-3446	912	38	-	-	PUNCT
gs-3446	912	39	cas9	cas9	NOUN
gs-3446	912	40	,	,	PUNCT
gs-3446	912	41	ipscs	ipscs	NOUN