id	sid	tid	token	lemma	pos
gs-3688	1	1	microsoft	microsoft	PROPN
gs-3688	1	2	word	word	NOUN
gs-3688	1	3	fullpdf07022025	fullpdf07022025	PROPN
gs-3688	1	4	georgian	georgian	ADJ
gs-3688	1	5	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3688	1	6	მეცნიერები	მეცნიერები	NOUN
gs-3688	1	7	ტ.	ტ.	VERB
gs-3688	1	8	7	7	NUM
gs-3688	1	9	n	n	DET
gs-3688	1	10	2	2	NUM
gs-3688	1	11	,	,	PUNCT
gs-3688	1	12	2025	2025	NUM
gs-3688	1	13	298	298	NUM
gs-3688	1	14	georgian	georgian	ADJ
gs-3688	1	15	scientists	scientist	NOUN
gs-3688	1	16	ქართველი	ქართველი	ADJ
gs-3688	1	17	მეცნიერები	მეცნიერები	PROPN
gs-3688	1	18	vol	vol	NOUN
gs-3688	1	19	.	.	PUNCT
gs-3688	1	20	7	7	NUM
gs-3688	1	21	issue	issue	NOUN
gs-3688	1	22	2	2	NUM
gs-3688	1	23	,	,	PUNCT
gs-3688	1	24	2025	2025	NUM
gs-3688	1	25	https://doi.org/10.52340/gs.2025.07.02.28	https://doi.org/10.52340/gs.2025.07.02.28	PRON
gs-3688	1	26	quantitative	quantitative	ADJ
gs-3688	1	27	determination	determination	NOUN
gs-3688	1	28	of	of	ADP
gs-3688	1	29	berberine	berberine	NOUN
gs-3688	1	30	in	in	ADP
gs-3688	1	31	the	the	DET
gs-3688	1	32	aboveground	aboveground	ADJ
gs-3688	1	33	organs	organ	NOUN
gs-3688	1	34	of	of	ADP
gs-3688	1	35	mahonia	mahonia	NOUN
gs-3688	1	36	aquifolium	aquifolium	PROPN
gs-3688	1	37	(	(	PUNCT
gs-3688	1	38	pursh	pursh	NOUN
gs-3688	1	39	)	)	PUNCT
gs-3688	1	40	nutt	nutt	NOUN
gs-3688	1	41	.	.	PUNCT
gs-3688	2	1	nika	nika	PROPN
gs-3688	2	2	toduaa	toduaa	PROPN
gs-3688	2	3	*	*	PROPN
gs-3688	2	4	,	,	PUNCT
gs-3688	2	5	malkhaz	malkhaz	PROPN
gs-3688	2	6	getiab	getiab	PROPN
gs-3688	2	7	,	,	PUNCT
gs-3688	2	8	davit	davit	NOUN
gs-3688	2	9	chincharadzea	chincharadzea	NOUN
gs-3688	2	10	,	,	PUNCT
gs-3688	2	11	nina	nina	PROPN
gs-3688	2	12	vachnadzeb	vachnadzeb	PROPN
gs-3688	2	13	atbilisi	atbilisi	VERB
gs-3688	2	14	state	state	PROPN
gs-3688	2	15	medical	medical	ADJ
gs-3688	2	16	university	university	NOUN
gs-3688	2	17	,	,	PUNCT
gs-3688	2	18	department	department	NOUN
gs-3688	2	19	of	of	ADP
gs-3688	2	20	pharmacognosy	pharmacognosy	NOUN
gs-3688	2	21	,	,	PUNCT
gs-3688	2	22	tbilisi	tbilisi	PROPN
gs-3688	2	23	,	,	PUNCT
gs-3688	2	24	georgia	georgia	PROPN
gs-3688	2	25	;	;	PUNCT
gs-3688	2	26	btbilisi	btbilisi	PROPN
gs-3688	2	27	state	state	PROPN
gs-3688	2	28	medical	medical	ADJ
gs-3688	2	29	university	university	NOUN
gs-3688	2	30	,	,	PUNCT
gs-3688	2	31	iovel	iovel	PROPN
gs-3688	2	32	kutateladze	kutateladze	PROPN
gs-3688	2	33	institute	institute	PROPN
gs-3688	2	34	of	of	ADP
gs-3688	2	35	pharmacochemistry	pharmacochemistry	PROPN
gs-3688	2	36	,	,	PUNCT
gs-3688	2	37	tbilisi	tbilisi	PROPN
gs-3688	2	38	,	,	PUNCT
gs-3688	2	39	georgia	georgia	PROPN
gs-3688	2	40	*	*	PUNCT
gs-3688	2	41	nika	nika	PROPN
gs-3688	2	42	todua	todua	PROPN
gs-3688	2	43	,	,	PUNCT
gs-3688	2	44	e	e	NOUN
gs-3688	2	45	-	-	NOUN
gs-3688	2	46	mail	mail	NOUN
gs-3688	2	47	:	:	PUNCT
gs-3688	2	48	nika.todua@yahoo.com	nika.todua@yahoo.com	X
gs-3688	2	49	abstract	abstract	VERB
gs-3688	2	50	our	our	PRON
gs-3688	2	51	study	study	NOUN
gs-3688	2	52	's	's	PART
gs-3688	2	53	objective	objective	NOUN
gs-3688	2	54	was	be	AUX
gs-3688	2	55	to	to	PART
gs-3688	2	56	use	use	VERB
gs-3688	2	57	high	high	ADJ
gs-3688	2	58	-	-	PUNCT
gs-3688	2	59	performance	performance	NOUN
gs-3688	2	60	liquid	liquid	ADJ
gs-3688	2	61	chromatography	chromatography	NOUN
gs-3688	2	62	(	(	PUNCT
gs-3688	2	63	hplc	hplc	PROPN
gs-3688	2	64	)	)	PUNCT
gs-3688	2	65	to	to	PART
gs-3688	2	66	quantify	quantify	VERB
gs-3688	2	67	the	the	DET
gs-3688	2	68	amount	amount	NOUN
gs-3688	2	69	of	of	ADP
gs-3688	2	70	berberine	berberine	NOUN
gs-3688	2	71	in	in	ADP
gs-3688	2	72	the	the	DET
gs-3688	2	73	total	total	ADJ
gs-3688	2	74	amount	amount	NOUN
gs-3688	2	75	of	of	ADP
gs-3688	2	76	alkaloids	alkaloid	NOUN
gs-3688	2	77	extracted	extract	VERB
gs-3688	2	78	from	from	ADP
gs-3688	2	79	m.	m.	PROPN
gs-3688	2	80	aquifolium	aquifolium	PROPN
gs-3688	2	81	.	.	PUNCT
gs-3688	3	1	eclipse	eclipse	NOUN
gs-3688	3	2	plus	plus	CCONJ
gs-3688	3	3	c-18	c-18	PROPN
gs-3688	3	4	was	be	AUX
gs-3688	3	5	used	use	VERB
gs-3688	3	6	to	to	PART
gs-3688	3	7	separate	separate	VERB
gs-3688	3	8	the	the	DET
gs-3688	3	9	crude	crude	ADJ
gs-3688	3	10	extract	extract	NOUN
gs-3688	3	11	(	(	PUNCT
gs-3688	3	12	250	250	NUM
gs-3688	3	13	x	x	SYM
gs-3688	3	14	4.6	4.6	NUM
gs-3688	3	15	x	x	SYM
gs-3688	3	16	5	5	NUM
gs-3688	3	17	µm	µm	NOUN
gs-3688	3	18	)	)	PUNCT
gs-3688	3	19	.	.	PUNCT
gs-3688	4	1	methanol	methanol	NOUN
gs-3688	4	2	(	(	PUNCT
gs-3688	4	3	0.1	0.1	NUM
gs-3688	4	4	%	%	NOUN
gs-3688	4	5	formic	formic	ADJ
gs-3688	4	6	acid	acid	NOUN
gs-3688	4	7	):	):	PUNCT
gs-3688	4	8	water	water	NOUN
gs-3688	4	9	(	(	PUNCT
gs-3688	4	10	0.1	0.1	NUM
gs-3688	4	11	formic	formic	NOUN
gs-3688	4	12	acid	acid	NOUN
gs-3688	4	13	)	)	PUNCT
gs-3688	4	14	35:65	35:65	NUM
gs-3688	4	15	v	v	ADP
gs-3688	4	16	v-1	v-1	PROPN
gs-3688	4	17	made	make	VERB
gs-3688	4	18	up	up	ADP
gs-3688	4	19	the	the	DET
gs-3688	4	20	mobile	mobile	ADJ
gs-3688	4	21	phase	phase	NOUN
gs-3688	4	22	.	.	PUNCT
gs-3688	5	1	at	at	ADP
gs-3688	5	2	346	346	NUM
gs-3688	5	3	nm	nm	NOUN
gs-3688	5	4	,	,	PUNCT
gs-3688	5	5	ultraviolet	ultraviolet	ADJ
gs-3688	5	6	detection	detection	NOUN
gs-3688	5	7	was	be	AUX
gs-3688	5	8	carried	carry	VERB
gs-3688	5	9	out	out	ADP
gs-3688	5	10	.	.	PUNCT
gs-3688	6	1	with	with	ADP
gs-3688	6	2	a	a	DET
gs-3688	6	3	r2	r2	PROPN
gs-3688	6	4	>	>	X
gs-3688	6	5	0.9998	0.9998	NUM
gs-3688	6	6	,	,	PUNCT
gs-3688	6	7	a	a	DET
gs-3688	6	8	solid	solid	ADJ
gs-3688	6	9	linear	linear	ADJ
gs-3688	6	10	response	response	NOUN
gs-3688	6	11	was	be	AUX
gs-3688	6	12	seen	see	VERB
gs-3688	6	13	in	in	ADP
gs-3688	6	14	the	the	DET
gs-3688	6	15	concentration	concentration	NOUN
gs-3688	6	16	range	range	NOUN
gs-3688	6	17	under	under	ADP
gs-3688	6	18	study	study	NOUN
gs-3688	6	19	.	.	PUNCT
gs-3688	7	1	the	the	DET
gs-3688	7	2	alkaloid	alkaloid	PROPN
gs-3688	7	3	extract	extract	NOUN
gs-3688	7	4	from	from	ADP
gs-3688	7	5	the	the	DET
gs-3688	7	6	aerial	aerial	ADJ
gs-3688	7	7	parts	part	NOUN
gs-3688	7	8	of	of	ADP
gs-3688	7	9	m.	m.	PROPN
gs-3688	7	10	aquifolium	aquifolium	PROPN
gs-3688	7	11	should	should	AUX
gs-3688	7	12	contain	contain	VERB
gs-3688	7	13	at	at	ADV
gs-3688	7	14	least	least	ADJ
gs-3688	7	15	2	2	NUM
gs-3688	7	16	%	%	NOUN
gs-3688	7	17	berberine	berberine	NOUN
gs-3688	7	18	,	,	PUNCT
gs-3688	7	19	according	accord	VERB
gs-3688	7	20	to	to	ADP
gs-3688	7	21	the	the	DET
gs-3688	7	22	results	result	NOUN
gs-3688	7	23	.	.	PUNCT
gs-3688	8	1	with	with	ADP
gs-3688	8	2	intraand	intraand	NOUN
gs-3688	8	3	inter	inter	ADJ
gs-3688	8	4	-	-	ADJ
gs-3688	8	5	day	day	ADJ
gs-3688	8	6	variances	variance	NOUN
gs-3688	8	7	of	of	ADP
gs-3688	8	8	less	less	ADJ
gs-3688	8	9	than	than	ADP
gs-3688	8	10	1.03	1.03	NUM
gs-3688	8	11	%	%	NOUN
gs-3688	8	12	,	,	PUNCT
gs-3688	8	13	the	the	DET
gs-3688	8	14	approach	approach	NOUN
gs-3688	8	15	is	be	AUX
gs-3688	8	16	accurate	accurate	ADJ
gs-3688	8	17	.	.	PUNCT
gs-3688	9	1	within	within	ADP
gs-3688	9	2	the	the	DET
gs-3688	9	3	range	range	NOUN
gs-3688	9	4	under	under	ADP
gs-3688	9	5	study	study	NOUN
gs-3688	9	6	,	,	PUNCT
gs-3688	9	7	linearity	linearity	NOUN
gs-3688	9	8	,	,	PUNCT
gs-3688	9	9	sensitivity	sensitivity	NOUN
gs-3688	9	10	,	,	PUNCT
gs-3688	9	11	and	and	CCONJ
gs-3688	9	12	precision	precision	NOUN
gs-3688	9	13	are	be	AUX
gs-3688	9	14	all	all	ADV
gs-3688	9	15	adequate	adequate	ADJ
gs-3688	9	16	.	.	PUNCT
gs-3688	10	1	keywords	keyword	NOUN
gs-3688	10	2	:	:	PUNCT
gs-3688	10	3	alkaloids	alkaloid	NOUN
gs-3688	10	4	,	,	PUNCT
gs-3688	10	5	berberine	berberine	NOUN
gs-3688	10	6	,	,	PUNCT
gs-3688	10	7	bioactive	bioactive	PROPN
gs-3688	10	8	compounds	compound	NOUN
gs-3688	10	9	,	,	PUNCT
gs-3688	10	10	quantitative	quantitative	ADJ
gs-3688	10	11	analysis	analysis	NOUN
gs-3688	10	12	,	,	PUNCT
gs-3688	10	13	hplc	hplc	NOUN
gs-3688	10	14	.	.	PUNCT
gs-3688	11	1	1	1	X
gs-3688	11	2	.	.	X
gs-3688	11	3	introduction	introduction	NOUN
gs-3688	11	4	about	about	ADV
gs-3688	11	5	two	two	NUM
gs-3688	11	6	centuries	century	NOUN
gs-3688	11	7	ago	ago	ADV
gs-3688	11	8	,	,	PUNCT
gs-3688	11	9	the	the	DET
gs-3688	11	10	discovery	discovery	NOUN
gs-3688	11	11	of	of	ADP
gs-3688	11	12	alkaloids	alkaloid	NOUN
gs-3688	11	13	marked	mark	VERB
gs-3688	11	14	a	a	DET
gs-3688	11	15	new	new	ADJ
gs-3688	11	16	era	era	NOUN
gs-3688	11	17	in	in	ADP
gs-3688	11	18	medicine	medicine	NOUN
gs-3688	11	19	and	and	CCONJ
gs-3688	11	20	chemistry	chemistry	NOUN
gs-3688	11	21	.	.	PUNCT
gs-3688	12	1	in	in	ADP
gs-3688	12	2	modern	modern	ADJ
gs-3688	12	3	phytochemistry	phytochemistry	NOUN
gs-3688	12	4	,	,	PUNCT
gs-3688	12	5	the	the	DET
gs-3688	12	6	study	study	NOUN
gs-3688	12	7	of	of	ADP
gs-3688	12	8	biologically	biologically	ADV
gs-3688	12	9	active	active	ADJ
gs-3688	12	10	secondary	secondary	ADJ
gs-3688	12	11	metabolites	metabolite	NOUN
gs-3688	12	12	encompasses	encompass	VERB
gs-3688	12	13	several	several	ADJ
gs-3688	12	14	key	key	ADJ
gs-3688	12	15	areas	area	NOUN
gs-3688	12	16	:	:	PUNCT
gs-3688	12	17	exploration	exploration	NOUN
gs-3688	12	18	of	of	ADP
gs-3688	12	19	flora	flora	NOUN
gs-3688	12	20	for	for	ADP
gs-3688	12	21	alkaloid	alkaloid	NOUN
gs-3688	12	22	-	-	PUNCT
gs-3688	12	23	containing	contain	VERB
gs-3688	12	24	plants	plant	NOUN
gs-3688	12	25	,	,	PUNCT
gs-3688	12	26	selection	selection	NOUN
gs-3688	12	27	of	of	ADP
gs-3688	12	28	optimal	optimal	ADJ
gs-3688	12	29	methods	method	NOUN
gs-3688	12	30	for	for	ADP
gs-3688	12	31	extracting	extract	VERB
gs-3688	12	32	the	the	DET
gs-3688	12	33	total	total	ADJ
gs-3688	12	34	alkaloid	alkaloid	PROPN
gs-3688	12	35	content	content	NOUN
gs-3688	12	36	from	from	ADP
gs-3688	12	37	plant	plant	NOUN
gs-3688	12	38	materials	material	NOUN
gs-3688	12	39	,	,	PUNCT
gs-3688	12	40	and	and	CCONJ
gs-3688	12	41	isolation	isolation	NOUN
gs-3688	12	42	of	of	ADP
gs-3688	12	43	individual	individual	ADJ
gs-3688	12	44	compounds	compound	NOUN
gs-3688	12	45	.	.	PUNCT
gs-3688	13	1	additionally	additionally	ADV
gs-3688	13	2	,	,	PUNCT
gs-3688	13	3	there	there	PRON
gs-3688	13	4	is	be	VERB
gs-3688	13	5	an	an	DET
gs-3688	13	6	emphasis	emphasis	NOUN
gs-3688	13	7	on	on	ADP
gs-3688	13	8	identifying	identify	VERB
gs-3688	13	9	the	the	DET
gs-3688	13	10	structure	structure	NOUN
gs-3688	13	11	of	of	ADP
gs-3688	13	12	previously	previously	ADV
gs-3688	13	13	unknown	unknown	ADJ
gs-3688	13	14	alkaloids	alkaloid	NOUN
gs-3688	13	15	and	and	CCONJ
gs-3688	13	16	studying	study	VERB
gs-3688	13	17	their	their	PRON
gs-3688	13	18	pharmacological	pharmacological	ADJ
gs-3688	13	19	activity	activity	NOUN
gs-3688	13	20	to	to	PART
gs-3688	13	21	develop	develop	VERB
gs-3688	13	22	effective	effective	ADJ
gs-3688	13	23	medicinal	medicinal	ADJ
gs-3688	13	24	drugs	drug	NOUN
gs-3688	13	25	.	.	PUNCT
gs-3688	14	1	this	this	DET
gs-3688	14	2	research	research	NOUN
gs-3688	14	3	also	also	ADV
gs-3688	14	4	relies	rely	VERB
gs-3688	14	5	on	on	ADP
gs-3688	14	6	the	the	DET
gs-3688	14	7	latest	late	ADJ
gs-3688	14	8	technological	technological	ADJ
gs-3688	14	9	advancements	advancement	NOUN
gs-3688	14	10	and	and	CCONJ
gs-3688	14	11	includes	include	VERB
gs-3688	14	12	resource	resource	NOUN
gs-3688	14	13	studies	study	NOUN
gs-3688	14	14	,	,	PUNCT
gs-3688	14	15	as	as	ADV
gs-3688	14	16	well	well	ADV
gs-3688	14	17	as	as	ADP
gs-3688	14	18	addressing	address	VERB
gs-3688	14	19	any	any	DET
gs-3688	14	20	challenges	challenge	NOUN
gs-3688	14	21	related	relate	VERB
gs-3688	14	22	to	to	ADP
gs-3688	14	23	the	the	DET
gs-3688	14	24	cultivation	cultivation	NOUN
gs-3688	14	25	of	of	ADP
gs-3688	14	26	medicinal	medicinal	ADJ
gs-3688	14	27	plants	plant	NOUN
gs-3688	14	28	[	[	X
gs-3688	14	29	1	1	NUM
gs-3688	14	30	-	-	SYM
gs-3688	14	31	4	4	NUM
gs-3688	14	32	]	]	PUNCT
gs-3688	14	33	.	.	PUNCT
gs-3688	15	1	alkaloids	alkaloid	NOUN
gs-3688	15	2	are	be	AUX
gs-3688	15	3	abundant	abundant	ADJ
gs-3688	15	4	in	in	ADP
gs-3688	15	5	the	the	DET
gs-3688	15	6	kingdom	kingdom	NOUN
gs-3688	15	7	of	of	ADP
gs-3688	15	8	plants	plant	NOUN
gs-3688	15	9	and	and	CCONJ
gs-3688	15	10	have	have	VERB
gs-3688	15	11	a	a	DET
gs-3688	15	12	high	high	ADJ
gs-3688	15	13	level	level	NOUN
gs-3688	15	14	of	of	ADP
gs-3688	15	15	biological	biological	ADJ
gs-3688	15	16	activity	activity	NOUN
gs-3688	15	17	.	.	PUNCT
gs-3688	16	1	it	it	PRON
gs-3688	16	2	was	be	AUX
gs-3688	16	3	previously	previously	ADV
gs-3688	16	4	believed	believe	VERB
gs-3688	16	5	that	that	SCONJ
gs-3688	16	6	the	the	DET
gs-3688	16	7	alkaloid	alkaloid	PROPN
gs-3688	16	8	bases	basis	NOUN
gs-3688	16	9	found	find	VERB
gs-3688	16	10	in	in	ADP
gs-3688	16	11	a	a	DET
gs-3688	16	12	plant	plant	NOUN
gs-3688	16	13	's	's	PART
gs-3688	16	14	chemical	chemical	NOUN
gs-3688	16	15	composition	composition	NOUN
gs-3688	16	16	were	be	AUX
gs-3688	16	17	characteristic	characteristic	ADJ
gs-3688	16	18	and	and	CCONJ
gs-3688	16	19	specific	specific	ADJ
gs-3688	16	20	to	to	ADP
gs-3688	16	21	a	a	DET
gs-3688	16	22	particular	particular	ADJ
gs-3688	16	23	family	family	NOUN
gs-3688	16	24	.	.	PUNCT
gs-3688	17	1	however	however	ADV
gs-3688	17	2	,	,	PUNCT
gs-3688	17	3	studies	study	NOUN
gs-3688	17	4	on	on	ADP
gs-3688	17	5	their	their	PRON
gs-3688	17	6	distribution	distribution	NOUN
gs-3688	17	7	in	in	ADP
gs-3688	17	8	plants	plant	NOUN
gs-3688	17	9	have	have	AUX
gs-3688	17	10	shown	show	VERB
gs-3688	17	11	that	that	SCONJ
gs-3688	17	12	the	the	DET
gs-3688	17	13	same	same	ADJ
gs-3688	17	14	base	base	NOUN
gs-3688	17	15	can	can	AUX
gs-3688	17	16	be	be	AUX
gs-3688	17	17	present	present	ADJ
gs-3688	17	18	in	in	ADP
gs-3688	17	19	plants	plant	NOUN
gs-3688	17	20	from	from	ADP
gs-3688	17	21	entirely	entirely	ADV
gs-3688	17	22	different	different	ADJ
gs-3688	17	23	families	family	NOUN
gs-3688	17	24	.	.	PUNCT
gs-3688	18	1	for	for	ADP
gs-3688	18	2	instance	instance	NOUN
gs-3688	18	3	,	,	PUNCT
gs-3688	18	4	berberine	berberine	NOUN
gs-3688	18	5	,	,	PUNCT
gs-3688	18	6	one	one	NUM
gs-3688	18	7	of	of	ADP
gs-3688	18	8	the	the	DET
gs-3688	18	9	first	first	ADJ
gs-3688	18	10	alkaloids	alkaloid	NOUN
gs-3688	18	11	used	use	VERB
gs-3688	18	12	in	in	ADP
gs-3688	18	13	medicine	medicine	NOUN
gs-3688	18	14	,	,	PUNCT
gs-3688	18	15	has	have	AUX
gs-3688	18	16	attracted	attract	VERB
gs-3688	18	17	significant	significant	ADJ
gs-3688	18	18	interest	interest	NOUN
gs-3688	18	19	due	due	ADP
gs-3688	18	20	to	to	ADP
gs-3688	18	21	its	its	PRON
gs-3688	18	22	low	low	ADJ
gs-3688	18	23	toxicity	toxicity	NOUN
gs-3688	18	24	and	and	CCONJ
gs-3688	18	25	broad	broad	ADJ
gs-3688	18	26	biological	biological	ADJ
gs-3688	18	27	activity	activity	NOUN
gs-3688	18	28	.	.	PUNCT
gs-3688	19	1	berberine	berberine	NOUN
gs-3688	19	2	demonstrates	demonstrate	VERB
gs-3688	19	3	antioxidant	antioxidant	ADJ
gs-3688	19	4	,	,	PUNCT
gs-3688	19	5	anti	anti	ADJ
gs-3688	19	6	-	-	ADJ
gs-3688	19	7	inflammatory	inflammatory	ADJ
gs-3688	19	8	,	,	PUNCT
gs-3688	19	9	neuroprotective	neuroprotective	ADJ
gs-3688	19	10	,	,	PUNCT
gs-3688	19	11	antiviral	antiviral	ADJ
gs-3688	19	12	,	,	PUNCT
gs-3688	19	13	antibacterial	antibacterial	ADJ
gs-3688	19	14	,	,	PUNCT
gs-3688	19	15	hypoglycemic	hypoglycemic	ADJ
gs-3688	19	16	,	,	PUNCT
gs-3688	19	17	hypolipidemic	hypolipidemic	ADJ
gs-3688	19	18	,	,	PUNCT
gs-3688	19	19	antidepressant	antidepressant	ADJ
gs-3688	19	20	,	,	PUNCT
gs-3688	19	21	antidiarrheal	antidiarrheal	NOUN
gs-3688	19	22	,	,	PUNCT
gs-3688	19	23	and	and	CCONJ
gs-3688	19	24	anticancer	anticancer	NOUN
gs-3688	19	25	properties	property	NOUN
gs-3688	19	26	,	,	PUNCT
gs-3688	19	27	showing	show	VERB
gs-3688	19	28	efficacy	efficacy	NOUN
gs-3688	19	29	against	against	ADP
gs-3688	19	30	liver	liver	NOUN
gs-3688	19	31	tumors	tumor	NOUN
gs-3688	19	32	,	,	PUNCT
gs-3688	19	33	stomach	stomach	NOUN
gs-3688	19	34	cancer	cancer	NOUN
gs-3688	19	35	,	,	PUNCT
gs-3688	19	36	throat	throat	NOUN
gs-3688	19	37	cancer	cancer	NOUN
gs-3688	19	38	,	,	PUNCT
gs-3688	19	39	and	and	CCONJ
gs-3688	19	40	more	more	ADJ
gs-3688	19	41	.	.	PUNCT
gs-3688	20	1	it	it	PRON
gs-3688	20	2	is	be	AUX
gs-3688	20	3	also	also	ADV
gs-3688	20	4	used	use	VERB
gs-3688	20	5	to	to	PART
gs-3688	20	6	treat	treat	VERB
gs-3688	20	7	chronic	chronic	ADJ
gs-3688	20	8	hepatitis	hepatitis	NOUN
gs-3688	20	9	,	,	PUNCT
gs-3688	20	10	hepatobiliary	hepatobiliary	ADJ
gs-3688	20	11	disease	disease	NOUN
gs-3688	20	12	,	,	PUNCT
gs-3688	20	13	cholecystitis	cholecystitis	NOUN
gs-3688	20	14	,	,	PUNCT
gs-3688	20	15	gallstone	gallstone	NOUN
gs-3688	20	16	disease	disease	NOUN
gs-3688	20	17	,	,	PUNCT
gs-3688	20	18	and	and	CCONJ
gs-3688	20	19	other	other	ADJ
gs-3688	20	20	conditions	condition	NOUN
gs-3688	20	21	[	[	X
gs-3688	20	22	5	5	NUM
gs-3688	20	23	-	-	SYM
gs-3688	20	24	26	26	NUM
gs-3688	20	25	]	]	PUNCT
gs-3688	20	26	.	.	PUNCT
gs-3688	21	1	georgian	georgian	PROPN
gs-3688	21	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3688	21	3	მეცნიერები	მეცნიერები	NOUN
gs-3688	21	4	ტ.	ტ.	VERB
gs-3688	21	5	7	7	NUM
gs-3688	21	6	n	n	DET
gs-3688	21	7	2	2	NUM
gs-3688	21	8	,	,	PUNCT
gs-3688	21	9	2025	2025	NUM
gs-3688	21	10	299	299	NUM
gs-3688	21	11	one	one	NUM
gs-3688	21	12	of	of	ADP
gs-3688	21	13	the	the	DET
gs-3688	21	14	rich	rich	ADJ
gs-3688	21	15	sources	source	NOUN
gs-3688	21	16	of	of	ADP
gs-3688	21	17	the	the	DET
gs-3688	21	18	biologically	biologically	ADV
gs-3688	21	19	active	active	ADJ
gs-3688	21	20	alkaloid	alkaloid	ADJ
gs-3688	21	21	berberine	berberine	NOUN
gs-3688	21	22	is	be	AUX
gs-3688	21	23	the	the	DET
gs-3688	21	24	genus	genus	ADJ
gs-3688	21	25	mahonia	mahonia	NOUN
gs-3688	21	26	nutt	nutt	NOUN
gs-3688	21	27	.	.	PUNCT
gs-3688	22	1	(	(	PUNCT
gs-3688	22	2	family	family	NOUN
gs-3688	22	3	berberidaceae	berberidaceae	NOUN
gs-3688	22	4	)	)	PUNCT
gs-3688	22	5	,	,	PUNCT
gs-3688	22	6	which	which	PRON
gs-3688	22	7	includes	include	VERB
gs-3688	22	8	around	around	ADP
gs-3688	22	9	60	60	NUM
gs-3688	22	10	plant	plant	NOUN
gs-3688	22	11	species	specie	NOUN
gs-3688	22	12	native	native	ADJ
gs-3688	22	13	to	to	ADP
gs-3688	22	14	asia	asia	PROPN
gs-3688	22	15	,	,	PUNCT
gs-3688	22	16	north	north	PROPN
gs-3688	22	17	america	america	PROPN
gs-3688	22	18	,	,	PUNCT
gs-3688	22	19	and	and	CCONJ
gs-3688	22	20	europe	europe	PROPN
gs-3688	22	21	.	.	PUNCT
gs-3688	23	1	in	in	ADP
gs-3688	23	2	georgia	georgia	PROPN
gs-3688	23	3	,	,	PUNCT
gs-3688	23	4	mahonia	mahonia	NOUN
gs-3688	23	5	is	be	AUX
gs-3688	23	6	represented	represent	VERB
gs-3688	23	7	at	at	ADP
gs-3688	23	8	the	the	DET
gs-3688	23	9	batumi	batumi	ADJ
gs-3688	23	10	botanical	botanical	ADJ
gs-3688	23	11	garden	garden	NOUN
gs-3688	23	12	on	on	ADP
gs-3688	23	13	the	the	DET
gs-3688	23	14	shore	shore	NOUN
gs-3688	23	15	of	of	ADP
gs-3688	23	16	the	the	DET
gs-3688	23	17	black	black	ADJ
gs-3688	23	18	sea	sea	NOUN
gs-3688	23	19	(	(	PUNCT
gs-3688	23	20	adjara	adjara	NOUN
gs-3688	23	21	)	)	PUNCT
gs-3688	23	22	by	by	ADP
gs-3688	23	23	a	a	DET
gs-3688	23	24	collection	collection	NOUN
gs-3688	23	25	of	of	ADP
gs-3688	23	26	naturalized	naturalize	VERB
gs-3688	23	27	plants	plant	NOUN
gs-3688	23	28	comprising	comprise	VERB
gs-3688	23	29	six	six	NUM
gs-3688	23	30	species	specie	NOUN
gs-3688	23	31	,	,	PUNCT
gs-3688	23	32	including	include	VERB
gs-3688	23	33	m.	m.	NOUN
gs-3688	23	34	aquifolium	aquifolium	PROPN
gs-3688	23	35	(	(	PUNCT
gs-3688	23	36	pursh	pursh	NOUN
gs-3688	23	37	)	)	PUNCT
gs-3688	23	38	nutt	nutt	NOUN
gs-3688	23	39	.	.	PROPN
gs-3688	23	40	,	,	PUNCT
gs-3688	23	41	which	which	PRON
gs-3688	23	42	is	be	AUX
gs-3688	23	43	well	well	ADV
gs-3688	23	44	-	-	PUNCT
gs-3688	23	45	known	know	VERB
gs-3688	23	46	for	for	ADP
gs-3688	23	47	its	its	PRON
gs-3688	23	48	medicinal	medicinal	ADJ
gs-3688	23	49	properties	property	NOUN
gs-3688	23	50	.	.	PUNCT
gs-3688	24	1	this	this	DET
gs-3688	24	2	species	specie	NOUN
gs-3688	24	3	is	be	AUX
gs-3688	24	4	widely	widely	ADV
gs-3688	24	5	used	use	VERB
gs-3688	24	6	in	in	ADP
gs-3688	24	7	traditional	traditional	ADJ
gs-3688	24	8	and	and	CCONJ
gs-3688	24	9	folk	folk	NOUN
gs-3688	24	10	medicine	medicine	NOUN
gs-3688	24	11	(	(	PUNCT
gs-3688	24	12	in	in	ADP
gs-3688	24	13	chinese	chinese	ADJ
gs-3688	24	14	and	and	CCONJ
gs-3688	24	15	north	north	ADJ
gs-3688	24	16	american	american	ADJ
gs-3688	24	17	practices	practice	NOUN
gs-3688	24	18	)	)	PUNCT
gs-3688	24	19	as	as	ADV
gs-3688	24	20	well	well	ADV
gs-3688	24	21	as	as	ADP
gs-3688	24	22	in	in	ADP
gs-3688	24	23	modern	modern	ADJ
gs-3688	24	24	practical	practical	ADJ
gs-3688	24	25	medicine	medicine	NOUN
gs-3688	24	26	,	,	PUNCT
gs-3688	24	27	especially	especially	ADV
gs-3688	24	28	for	for	ADP
gs-3688	24	29	the	the	DET
gs-3688	24	30	treatment	treatment	NOUN
gs-3688	24	31	of	of	ADP
gs-3688	24	32	skin	skin	NOUN
gs-3688	24	33	diseases	disease	NOUN
gs-3688	24	34	.	.	PUNCT
gs-3688	25	1	mahonia	mahonia	NOUN
gs-3688	25	2	aquifolium	aquifolium	PROPN
gs-3688	25	3	(	(	PUNCT
gs-3688	25	4	pursh	pursh	NOUN
gs-3688	25	5	)	)	PUNCT
gs-3688	25	6	nutt	nutt	NOUN
gs-3688	25	7	also	also	ADV
gs-3688	25	8	known	know	VERB
gs-3688	25	9	as	as	ADP
gs-3688	25	10	berberis	berberis	PROPN
gs-3688	25	11	aquifolium	aquifolium	PROPN
gs-3688	25	12	pursh	pursh	NOUN
gs-3688	25	13	[	[	X
gs-3688	25	14	27	27	NUM
gs-3688	25	15	-	-	SYM
gs-3688	25	16	30	30	NUM
gs-3688	25	17	]	]	PUNCT
gs-3688	25	18	.	.	PUNCT
gs-3688	26	1	however	however	ADV
gs-3688	26	2	,	,	PUNCT
gs-3688	26	3	there	there	PRON
gs-3688	26	4	is	be	VERB
gs-3688	26	5	a	a	DET
gs-3688	26	6	lack	lack	NOUN
gs-3688	26	7	of	of	ADP
gs-3688	26	8	scientific	scientific	ADJ
gs-3688	26	9	research	research	NOUN
gs-3688	26	10	data	datum	NOUN
gs-3688	26	11	on	on	ADP
gs-3688	26	12	the	the	DET
gs-3688	26	13	chemical	chemical	NOUN
gs-3688	26	14	,	,	PUNCT
gs-3688	26	15	and	and	CCONJ
gs-3688	26	16	particularly	particularly	ADV
gs-3688	26	17	the	the	DET
gs-3688	26	18	alkaloid	alkaloid	NOUN
gs-3688	26	19	,	,	PUNCT
gs-3688	26	20	composition	composition	NOUN
gs-3688	26	21	of	of	ADP
gs-3688	26	22	this	this	DET
gs-3688	26	23	species	specie	NOUN
gs-3688	26	24	introduced	introduce	VERB
gs-3688	26	25	in	in	ADP
gs-3688	26	26	georgia	georgia	PROPN
gs-3688	26	27	,	,	PUNCT
gs-3688	26	28	as	as	SCONJ
gs-3688	26	29	it	it	PRON
gs-3688	26	30	has	have	AUX
gs-3688	26	31	primarily	primarily	ADV
gs-3688	26	32	been	be	AUX
gs-3688	26	33	used	use	VERB
gs-3688	26	34	for	for	ADP
gs-3688	26	35	ornamental	ornamental	ADJ
gs-3688	26	36	purposes	purpose	NOUN
gs-3688	26	37	in	in	ADP
gs-3688	26	38	gardens	garden	NOUN
gs-3688	26	39	and	and	CCONJ
gs-3688	26	40	parks	park	NOUN
gs-3688	26	41	.	.	PUNCT
gs-3688	27	1	based	base	VERB
gs-3688	27	2	on	on	ADP
gs-3688	27	3	the	the	DET
gs-3688	27	4	above	above	ADJ
gs-3688	27	5	,	,	PUNCT
gs-3688	27	6	preliminary	preliminary	ADJ
gs-3688	27	7	qualitative	qualitative	ADJ
gs-3688	27	8	analysis	analysis	NOUN
gs-3688	27	9	confirmed	confirm	VERB
gs-3688	27	10	the	the	DET
gs-3688	27	11	presence	presence	NOUN
gs-3688	27	12	of	of	ADP
gs-3688	27	13	alkaloids	alkaloid	NOUN
gs-3688	27	14	in	in	ADP
gs-3688	27	15	the	the	DET
gs-3688	27	16	introduced	introduce	VERB
gs-3688	27	17	m.	m.	NOUN
gs-3688	27	18	aquifolium	aquifolium	PROPN
gs-3688	27	19	.	.	PUNCT
gs-3688	28	1	phytochemical	phytochemical	ADJ
gs-3688	28	2	analysis	analysis	NOUN
gs-3688	28	3	further	far	ADV
gs-3688	28	4	indicated	indicate	VERB
gs-3688	28	5	that	that	SCONJ
gs-3688	28	6	all	all	DET
gs-3688	28	7	vegetative	vegetative	ADJ
gs-3688	28	8	organs	organ	NOUN
gs-3688	28	9	of	of	ADP
gs-3688	28	10	the	the	DET
gs-3688	28	11	plant	plant	NOUN
gs-3688	28	12	contain	contain	VERB
gs-3688	28	13	isoquinoline	isoquinoline	ADJ
gs-3688	28	14	alkaloids	alkaloid	NOUN
gs-3688	28	15	to	to	ADP
gs-3688	28	16	varying	vary	VERB
gs-3688	28	17	degrees	degree	NOUN
gs-3688	28	18	,	,	PUNCT
gs-3688	28	19	including	include	VERB
gs-3688	28	20	the	the	DET
gs-3688	28	21	biologically	biologically	ADV
gs-3688	28	22	active	active	ADJ
gs-3688	28	23	berberine	berberine	NOUN
gs-3688	28	24	base	base	NOUN
gs-3688	28	25	.	.	PUNCT
gs-3688	29	1	the	the	DET
gs-3688	29	2	total	total	ADJ
gs-3688	29	3	alkaloid	alkaloid	NOUN
gs-3688	29	4	extract	extract	NOUN
gs-3688	29	5	from	from	ADP
gs-3688	29	6	the	the	DET
gs-3688	29	7	aerial	aerial	ADJ
gs-3688	29	8	parts	part	NOUN
gs-3688	29	9	of	of	ADP
gs-3688	29	10	the	the	DET
gs-3688	29	11	plants	plant	NOUN
gs-3688	29	12	,	,	PUNCT
gs-3688	29	13	which	which	PRON
gs-3688	29	14	contains	contain	VERB
gs-3688	29	15	biologically	biologically	ADV
gs-3688	29	16	active	active	ADJ
gs-3688	29	17	compounds	compound	NOUN
gs-3688	29	18	,	,	PUNCT
gs-3688	29	19	including	include	VERB
gs-3688	29	20	berberine	berberine	NOUN
gs-3688	29	21	,	,	PUNCT
gs-3688	29	22	exhibited	exhibit	VERB
gs-3688	29	23	below	below	ADP
gs-3688	29	24	mentioned	mention	VERB
gs-3688	29	25	activities	activity	NOUN
gs-3688	29	26	:	:	PUNCT
gs-3688	29	27	cytotoxicity	cytotoxicity	NOUN
gs-3688	29	28	was	be	AUX
gs-3688	29	29	evaluated	evaluate	VERB
gs-3688	29	30	in	in	ADP
gs-3688	29	31	vitro	vitro	X
gs-3688	29	32	using	use	VERB
gs-3688	29	33	the	the	DET
gs-3688	29	34	hoechst	hoechst	NOUN
gs-3688	29	35	(	(	PUNCT
gs-3688	29	36	dna	dna	NOUN
gs-3688	29	37	quantification	quantification	NOUN
gs-3688	29	38	)	)	PUNCT
gs-3688	29	39	and	and	CCONJ
gs-3688	29	40	resazurine	resazurine	NOUN
gs-3688	29	41	spectrophotometric	spectrophotometric	ADJ
gs-3688	29	42	assays	assay	NOUN
gs-3688	29	43	which	which	PRON
gs-3688	29	44	demosntrated	demosntrate	VERB
gs-3688	29	45	high	high	ADJ
gs-3688	29	46	activity	activity	NOUN
gs-3688	29	47	against	against	ADP
gs-3688	29	48	lung	lung	NOUN
gs-3688	29	49	cancer	cancer	NOUN
gs-3688	29	50	carcinoma	carcinoma	NOUN
gs-3688	29	51	a-549	a-549	PROPN
gs-3688	29	52	,	,	PUNCT
gs-3688	29	53	colon	colon	NOUN
gs-3688	29	54	cancer	cancer	NOUN
gs-3688	29	55	dld-1	dld-1	SYM
gs-3688	29	56	,	,	PUNCT
gs-3688	29	57	and	and	CCONJ
gs-3688	29	58	normal	normal	ADJ
gs-3688	29	59	fibroblast	fibroblast	ADJ
gs-3688	29	60	ws-1	ws-1	NOUN
gs-3688	29	61	cell	cell	NOUN
gs-3688	29	62	lines	line	NOUN
gs-3688	29	63	.	.	PUNCT
gs-3688	30	1	antibacterial	antibacterial	ADJ
gs-3688	30	2	activity	activity	NOUN
gs-3688	30	3	was	be	AUX
gs-3688	30	4	evaluated	evaluate	VERB
gs-3688	30	5	using	use	VERB
gs-3688	30	6	the	the	DET
gs-3688	30	7	microdilution	microdilution	NOUN
gs-3688	30	8	method	method	NOUN
gs-3688	30	9	exhibited	exhibit	VERB
gs-3688	30	10	moderate	moderate	ADJ
gs-3688	30	11	activity	activity	NOUN
gs-3688	30	12	.	.	PUNCT
gs-3688	31	1	inflamatory	inflamatory	ADJ
gs-3688	31	2	asay	asay	PROPN
gs-3688	31	3	showed	show	VERB
gs-3688	31	4	us	we	PRON
gs-3688	31	5	is	be	AUX
gs-3688	31	6	low	low	ADJ
gs-3688	31	7	toxicict	toxicict	NOUN
gs-3688	31	8	to	to	ADP
gs-3688	31	9	raw	raw	ADJ
gs-3688	31	10	264.7	264.7	NUM
gs-3688	31	11	cells	cell	NOUN
gs-3688	31	12	.	.	PUNCT
gs-3688	32	1	the	the	DET
gs-3688	32	2	antiproliferative	antiproliferative	NOUN
gs-3688	32	3	and	and	CCONJ
gs-3688	32	4	antipsoriatic	antipsoriatic	ADJ
gs-3688	32	5	activity	activity	NOUN
gs-3688	32	6	was	be	AUX
gs-3688	32	7	evaluated	evaluate	VERB
gs-3688	32	8	quantitatively	quantitatively	ADV
gs-3688	32	9	against	against	ADP
gs-3688	32	10	human	human	ADJ
gs-3688	32	11	keratinocytes	keratinocyte	NOUN
gs-3688	32	12	of	of	ADP
gs-3688	32	13	the	the	DET
gs-3688	32	14	hacat	hacat	PROPN
gs-3688	32	15	line	line	NOUN
gs-3688	32	16	,	,	PUNCT
gs-3688	32	17	which	which	PRON
gs-3688	32	18	showed	show	VERB
gs-3688	32	19	that	that	SCONJ
gs-3688	32	20	it	it	PRON
gs-3688	32	21	exhibits	exhibit	VERB
gs-3688	32	22	a	a	DET
gs-3688	32	23	pronounced	pronounced	ADJ
gs-3688	32	24	cytotoxic	cytotoxic	ADJ
gs-3688	32	25	effect	effect	NOUN
gs-3688	32	26	on	on	ADP
gs-3688	32	27	cultured	cultured	ADJ
gs-3688	32	28	human	human	ADJ
gs-3688	32	29	hacat	hacat	NOUN
gs-3688	32	30	cells	cell	NOUN
gs-3688	32	31	and	and	CCONJ
gs-3688	32	32	a	a	DET
gs-3688	32	33	significant	significant	ADJ
gs-3688	32	34	antiproliferative	antiproliferative	ADJ
gs-3688	32	35	effect	effect	NOUN
gs-3688	32	36	on	on	ADP
gs-3688	32	37	cultured	cultured	ADJ
gs-3688	32	38	human	human	ADJ
gs-3688	32	39	hacat	hacat	PROPN
gs-3688	32	40	cells	cell	NOUN
gs-3688	32	41	at	at	ADP
gs-3688	32	42	concentrations	concentration	NOUN
gs-3688	32	43	lower	low	ADJ
gs-3688	32	44	than	than	ADP
gs-3688	32	45	the	the	DET
gs-3688	32	46	cytotoxic	cytotoxic	ADJ
gs-3688	32	47	ones	one	NOUN
gs-3688	32	48	.	.	PUNCT
gs-3688	33	1	for	for	ADP
gs-3688	33	2	determination	determination	NOUN
gs-3688	33	3	of	of	ADP
gs-3688	33	4	antioxidant	antioxidant	ADJ
gs-3688	33	5	activity	activity	NOUN
gs-3688	33	6	was	be	AUX
gs-3688	33	7	used	use	VERB
gs-3688	33	8	the	the	DET
gs-3688	33	9	dcfh	dcfh	NOUN
gs-3688	33	10	-	-	PUNCT
gs-3688	33	11	da	da	NOUN
gs-3688	33	12	,	,	PUNCT
gs-3688	33	13	compared	compare	VERB
gs-3688	33	14	to	to	ADP
gs-3688	33	15	quercetin	quercetin	VERB
gs-3688	33	16	both	both	PRON
gs-3688	33	17	in	in	ADP
gs-3688	33	18	the	the	DET
gs-3688	33	19	orac	orac	NOUN
gs-3688	33	20	test	test	NOUN
gs-3688	33	21	and	and	CCONJ
gs-3688	33	22	in	in	ADP
gs-3688	33	23	the	the	DET
gs-3688	33	24	in	in	ADV
gs-3688	33	25	vitro	vitro	X
gs-3688	33	26	test	test	NOUN
gs-3688	33	27	ic50	ic50	PROPN
gs-3688	33	28	using	use	VERB
gs-3688	33	29	a	a	DET
gs-3688	33	30	cellular	cellular	ADJ
gs-3688	33	31	model	model	NOUN
gs-3688	33	32	.	.	PUNCT
gs-3688	34	1	the	the	DET
gs-3688	34	2	main	main	ADJ
gs-3688	34	3	constituent	constituent	NOUN
gs-3688	34	4	in	in	ADP
gs-3688	34	5	the	the	DET
gs-3688	34	6	extracted	extract	VERB
gs-3688	34	7	sum	sum	NOUN
gs-3688	34	8	of	of	ADP
gs-3688	34	9	m.	m.	NOUN
gs-3688	34	10	aquifolium	aquifolium	PROPN
gs-3688	34	11	,	,	PUNCT
gs-3688	34	12	are	be	AUX
gs-3688	34	13	quinolone	quinolone	NOUN
gs-3688	34	14	alkaloids	alkaloid	NOUN
gs-3688	34	15	.	.	PUNCT
gs-3688	35	1	the	the	DET
gs-3688	35	2	pharmacologically	pharmacologically	ADV
gs-3688	35	3	and	and	CCONJ
gs-3688	35	4	biologically	biologically	ADV
gs-3688	35	5	active	active	ADJ
gs-3688	35	6	berberine	berberine	NOUN
gs-3688	35	7	is	be	AUX
gs-3688	35	8	dominant	dominant	ADJ
gs-3688	35	9	compound	compound	NOUN
gs-3688	35	10	within	within	ADP
gs-3688	35	11	sum	sum	NOUN
gs-3688	35	12	of	of	ADP
gs-3688	35	13	alkaloids	alkaloid	NOUN
gs-3688	35	14	.	.	PUNCT
gs-3688	36	1	the	the	DET
gs-3688	36	2	berberine	berberine	NOUN
gs-3688	36	3	was	be	AUX
gs-3688	36	4	selected	select	VERB
gs-3688	36	5	as	as	ADP
gs-3688	36	6	a	a	DET
gs-3688	36	7	marker	marker	NOUN
gs-3688	36	8	(	(	PUNCT
gs-3688	36	9	chemical	chemical	NOUN
gs-3688	36	10	and	and	CCONJ
gs-3688	36	11	biological	biological	ADJ
gs-3688	36	12	)	)	PUNCT
gs-3688	36	13	of	of	ADP
gs-3688	36	14	sum	sum	NOUN
gs-3688	36	15	.	.	PUNCT
gs-3688	37	1	therefore	therefore	ADV
gs-3688	37	2	,	,	PUNCT
gs-3688	37	3	our	our	PRON
gs-3688	37	4	study	study	NOUN
gs-3688	37	5	's	's	PART
gs-3688	37	6	objective	objective	NOUN
gs-3688	37	7	was	be	AUX
gs-3688	37	8	to	to	PART
gs-3688	37	9	use	use	VERB
gs-3688	37	10	highperformance	highperformance	NOUN
gs-3688	37	11	liquid	liquid	NOUN
gs-3688	37	12	chromatography	chromatography	NOUN
gs-3688	37	13	(	(	PUNCT
gs-3688	37	14	hplc	hplc	PROPN
gs-3688	37	15	)	)	PUNCT
gs-3688	37	16	to	to	PART
gs-3688	37	17	quantify	quantify	VERB
gs-3688	37	18	the	the	DET
gs-3688	37	19	amount	amount	NOUN
gs-3688	37	20	of	of	ADP
gs-3688	37	21	berberine	berberine	NOUN
gs-3688	37	22	in	in	ADP
gs-3688	37	23	the	the	DET
gs-3688	37	24	total	total	ADJ
gs-3688	37	25	amount	amount	NOUN
gs-3688	37	26	of	of	ADP
gs-3688	37	27	alkaloids	alkaloid	NOUN
gs-3688	37	28	extracted	extract	VERB
gs-3688	37	29	from	from	ADP
gs-3688	37	30	m.	m.	PROPN
gs-3688	37	31	aquifolium	aquifolium	PROPN
gs-3688	37	32	.	.	PUNCT
gs-3688	38	1	figure	figure	NOUN
gs-3688	38	2	1	1	NUM
gs-3688	38	3	.	.	PUNCT
gs-3688	38	4	mahonia	mahonia	NOUN
gs-3688	38	5	aquifolium	aquifolium	PROPN
gs-3688	38	6	(	(	PUNCT
gs-3688	38	7	pursh	pursh	NOUN
gs-3688	38	8	)	)	PUNCT
gs-3688	38	9	nutt	nutt	NOUN
gs-3688	38	10	.	.	PUNCT
gs-3688	39	1	georgian	georgian	ADJ
gs-3688	39	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3688	39	3	მეცნიერები	მეცნიერები	NOUN
gs-3688	39	4	ტ.	ტ.	VERB
gs-3688	39	5	7	7	NUM
gs-3688	39	6	n	n	DET
gs-3688	39	7	2	2	NUM
gs-3688	39	8	,	,	PUNCT
gs-3688	39	9	2025	2025	NUM
gs-3688	39	10	300	300	NUM
gs-3688	39	11	2	2	NUM
gs-3688	39	12	.	.	PUNCT
gs-3688	39	13	materials	material	NOUN
gs-3688	39	14	and	and	CCONJ
gs-3688	39	15	methods	method	NOUN
gs-3688	39	16	2.1	2.1	NUM
gs-3688	39	17	.	.	PUNCT
gs-3688	40	1	plant	plant	NOUN
gs-3688	40	2	material	material	NOUN
gs-3688	40	3	:	:	PUNCT
gs-3688	40	4	the	the	DET
gs-3688	40	5	study	study	NOUN
gs-3688	40	6	object	object	NOUN
gs-3688	40	7	was	be	AUX
gs-3688	40	8	m.	m.	NOUN
gs-3688	40	9	aquifolium	aquifolium	PROPN
gs-3688	40	10	nutt	nutt	PROPN
gs-3688	40	11	.	.	PROPN
gs-3688	40	12	,	,	PUNCT
gs-3688	40	13	collected	collect	VERB
gs-3688	40	14	in	in	ADP
gs-3688	40	15	the	the	DET
gs-3688	40	16	kartli	kartli	NOUN
gs-3688	40	17	floristic	floristic	ADJ
gs-3688	40	18	region	region	NOUN
gs-3688	40	19	:	:	PUNCT
gs-3688	40	20	n41.757750	n41.757750	NOUN
gs-3688	40	21	e044.762710	e044.762710	ADJ
gs-3688	40	22	,	,	PUNCT
gs-3688	40	23	h-485	h-485	NOUN
gs-3688	40	24	m	m	NOUN
gs-3688	40	25	,	,	PUNCT
gs-3688	40	26	in	in	ADP
gs-3688	40	27	2021	2021	NUM
gs-3688	40	28	.	.	PUNCT
gs-3688	41	1	the	the	DET
gs-3688	41	2	experimental	experimental	ADJ
gs-3688	41	3	specimen	speciman	NOUN
gs-3688	41	4	is	be	AUX
gs-3688	41	5	stored	store	VERB
gs-3688	41	6	in	in	ADP
gs-3688	41	7	the	the	DET
gs-3688	41	8	herbarium	herbarium	NOUN
gs-3688	41	9	of	of	ADP
gs-3688	41	10	tsmu	tsmu	NOUN
gs-3688	41	11	's	's	PART
gs-3688	41	12	i.	i.	PROPN
gs-3688	41	13	kutateladze	kutateladze	PROPN
gs-3688	41	14	institute	institute	PROPN
gs-3688	41	15	of	of	ADP
gs-3688	41	16	pharmacochemistry	pharmacochemistry	PROPN
gs-3688	41	17	(	(	PUNCT
gs-3688	41	18	tbph	tbph	NOUN
gs-3688	41	19	no	no	NOUN
gs-3688	41	20	.	.	NOUN
gs-3688	42	1	21343	21343	NUM
gs-3688	42	2	)	)	PUNCT
gs-3688	42	3	identification	identification	NOUN
gs-3688	42	4	of	of	ADP
gs-3688	42	5	study	study	NOUN
gs-3688	42	6	object	object	NOUN
gs-3688	42	7	was	be	AUX
gs-3688	42	8	performed	perform	VERB
gs-3688	42	9	with	with	ADP
gs-3688	42	10	comparison	comparison	NOUN
gs-3688	42	11	to	to	ADP
gs-3688	42	12	mentioned	mention	VERB
gs-3688	42	13	sample	sample	NOUN
gs-3688	42	14	of	of	ADP
gs-3688	42	15	herbarium	herbarium	NOUN
gs-3688	42	16	,	,	PUNCT
gs-3688	42	17	which	which	PRON
gs-3688	42	18	was	be	AUX
gs-3688	42	19	performed	perform	VERB
gs-3688	42	20	by	by	ADP
gs-3688	42	21	direction	direction	NOUN
gs-3688	42	22	of	of	ADP
gs-3688	42	23	pharmacobotany	pharmacobotany	NOUN
gs-3688	42	24	of	of	ADP
gs-3688	42	25	tbilisi	tbilisi	PROPN
gs-3688	42	26	state	state	PROPN
gs-3688	42	27	medical	medical	PROPN
gs-3688	42	28	universitiy	universitiy	PROPN
gs-3688	42	29	iovel	iovel	PROPN
gs-3688	42	30	kutateladze	kutateladze	PROPN
gs-3688	42	31	institue	institue	NOUN
gs-3688	42	32	of	of	ADP
gs-3688	42	33	pharmacochemistry	pharmacochemistry	NOUN
gs-3688	42	34	.	.	PUNCT
gs-3688	43	1	the	the	DET
gs-3688	43	2	newly	newly	ADV
gs-3688	43	3	collected	collect	VERB
gs-3688	43	4	partsof	partsof	NOUN
gs-3688	43	5	the	the	DET
gs-3688	43	6	plant	plant	NOUN
gs-3688	43	7	were	be	AUX
gs-3688	43	8	held	hold	VERB
gs-3688	43	9	up	up	ADP
gs-3688	43	10	with	with	ADP
gs-3688	43	11	air	air	NOUN
gs-3688	43	12	-	-	PUNCT
gs-3688	43	13	dried	dry	VERB
gs-3688	43	14	at	at	ADP
gs-3688	43	15	room	room	NOUN
gs-3688	43	16	temperature	temperature	NOUN
gs-3688	43	17	and	and	CCONJ
gs-3688	43	18	protected	protect	VERB
gs-3688	43	19	from	from	ADP
gs-3688	43	20	light	light	NOUN
gs-3688	43	21	and	and	CCONJ
gs-3688	43	22	humidity	humidity	NOUN
gs-3688	43	23	until	until	ADP
gs-3688	43	24	chemical	chemical	NOUN
gs-3688	43	25	analysis	analysis	NOUN
gs-3688	43	26	.	.	PUNCT
gs-3688	44	1	before	before	ADP
gs-3688	44	2	analysis	analysis	NOUN
gs-3688	44	3	,	,	PUNCT
gs-3688	44	4	the	the	DET
gs-3688	44	5	row	row	NOUN
gs-3688	44	6	materials	material	NOUN
gs-3688	44	7	were	be	AUX
gs-3688	44	8	powdered	powder	VERB
gs-3688	44	9	.	.	PUNCT
gs-3688	45	1	2.2	2.2	NUM
gs-3688	45	2	.	.	PUNCT
gs-3688	46	1	sample	sample	NOUN
gs-3688	46	2	preparation	preparation	NOUN
gs-3688	46	3	:	:	PUNCT
gs-3688	46	4	the	the	DET
gs-3688	46	5	extraction	extraction	NOUN
gs-3688	46	6	of	of	ADP
gs-3688	46	7	total	total	ADJ
gs-3688	46	8	alkaloids	alkaloid	NOUN
gs-3688	46	9	from	from	ADP
gs-3688	46	10	the	the	DET
gs-3688	46	11	aerial	aerial	ADJ
gs-3688	46	12	part	part	NOUN
gs-3688	46	13	of	of	ADP
gs-3688	46	14	m.	m.	NOUN
gs-3688	46	15	aquifolium	aquifolium	PROPN
gs-3688	46	16	followed	follow	VERB
gs-3688	46	17	a	a	DET
gs-3688	46	18	previously	previously	ADV
gs-3688	46	19	established	establish	VERB
gs-3688	46	20	classical	classical	ADJ
gs-3688	46	21	method	method	NOUN
gs-3688	46	22	.	.	PUNCT
gs-3688	47	1	finely	finely	ADV
gs-3688	47	2	ground	ground	NOUN
gs-3688	47	3	,	,	PUNCT
gs-3688	47	4	air	air	NOUN
gs-3688	47	5	-	-	PUNCT
gs-3688	47	6	dried	dry	VERB
gs-3688	47	7	plant	plant	NOUN
gs-3688	47	8	material	material	NOUN
gs-3688	47	9	(	(	PUNCT
gs-3688	47	10	50	50	NUM
gs-3688	47	11	g	g	NOUN
gs-3688	47	12	,	,	PUNCT
gs-3688	47	13	above	above	ADP
gs-3688	47	14	mentioned	mention	VERB
gs-3688	47	15	vegetative	vegetative	ADJ
gs-3688	47	16	parts	part	NOUN
gs-3688	47	17	were	be	AUX
gs-3688	47	18	selected	select	VERB
gs-3688	47	19	10	10	NUM
gs-3688	47	20	g	g	NOUN
gs-3688	47	21	each	each	PRON
gs-3688	47	22	)	)	PUNCT
gs-3688	47	23	was	be	AUX
gs-3688	47	24	pre	pre	VERB
gs-3688	47	25	-	-	VERB
gs-3688	47	26	alkalized	alkalize	VERB
gs-3688	47	27	with	with	ADP
gs-3688	47	28	12	12	NUM
gs-3688	47	29	%	%	NOUN
gs-3688	47	30	nh₄oh	nh₄oh	NOUN
gs-3688	47	31	,	,	PUNCT
gs-3688	47	32	then	then	ADV
gs-3688	47	33	extracted	extract	VERB
gs-3688	47	34	with	with	ADP
gs-3688	47	35	chcl₃	chcl₃	NOUN
gs-3688	47	36	by	by	ADP
gs-3688	47	37	maceration	maceration	NOUN
gs-3688	47	38	at	at	ADP
gs-3688	47	39	room	room	NOUN
gs-3688	47	40	temperature	temperature	NOUN
gs-3688	47	41	,	,	PUNCT
gs-3688	47	42	treated	treat	VERB
gs-3688	47	43	with	with	ADP
gs-3688	47	44	10	10	NUM
gs-3688	47	45	%	%	NOUN
gs-3688	47	46	h₂so₄	h₂so₄	ADJ
gs-3688	47	47	,	,	PUNCT
gs-3688	47	48	and	and	CCONJ
gs-3688	47	49	re	re	VERB
gs-3688	47	50	-	-	VERB
gs-3688	47	51	alkalized	alkalize	VERB
gs-3688	47	52	with	with	ADP
gs-3688	47	53	25	25	NUM
gs-3688	47	54	%	%	NOUN
gs-3688	47	55	nh₄oh	nh₄oh	NOUN
gs-3688	47	56	(	(	PUNCT
gs-3688	47	57	while	while	SCONJ
gs-3688	47	58	cooling	cool	VERB
gs-3688	47	59	)	)	PUNCT
gs-3688	47	60	to	to	ADP
gs-3688	47	61	a	a	DET
gs-3688	47	62	ph	ph	NOUN
gs-3688	47	63	of	of	ADP
gs-3688	47	64	9–10	9–10	NOUN
gs-3688	47	65	.	.	PUNCT
gs-3688	48	1	the	the	DET
gs-3688	48	2	alkaloids	alkaloid	NOUN
gs-3688	48	3	were	be	AUX
gs-3688	48	4	then	then	ADV
gs-3688	48	5	transferred	transfer	VERB
gs-3688	48	6	to	to	ADP
gs-3688	48	7	chcl₃	chcl₃	NOUN
gs-3688	48	8	in	in	ADP
gs-3688	48	9	their	their	PRON
gs-3688	48	10	base	base	NOUN
gs-3688	48	11	form	form	NOUN
gs-3688	48	12	.	.	PUNCT
gs-3688	49	1	the	the	DET
gs-3688	49	2	yield	yield	NOUN
gs-3688	49	3	of	of	ADP
gs-3688	49	4	total	total	ADJ
gs-3688	49	5	alkaloids	alkaloid	NOUN
gs-3688	49	6	from	from	ADP
gs-3688	49	7	the	the	DET
gs-3688	49	8	aerial	aerial	ADJ
gs-3688	49	9	parts	part	NOUN
gs-3688	49	10	of	of	ADP
gs-3688	49	11	m.	m.	PROPN
gs-3688	49	12	aquifolium	aquifolium	PROPN
gs-3688	49	13	,	,	PUNCT
gs-3688	49	14	obtained	obtain	VERB
gs-3688	49	15	as	as	ADP
gs-3688	49	16	an	an	DET
gs-3688	49	17	amorphous	amorphous	ADJ
gs-3688	49	18	brown	brown	ADJ
gs-3688	49	19	powder	powder	NOUN
gs-3688	49	20	,	,	PUNCT
gs-3688	49	21	was	be	AUX
gs-3688	49	22	0.51	0.51	NUM
gs-3688	49	23	g.	g.	NOUN
gs-3688	49	24	2.4	2.4	NUM
gs-3688	49	25	.	.	PUNCT
gs-3688	49	26	chemicals	chemical	NOUN
gs-3688	49	27	and	and	CCONJ
gs-3688	49	28	reagents	reagent	NOUN
gs-3688	49	29	:	:	PUNCT
gs-3688	49	30	hplc	hplc	NOUN
gs-3688	49	31	grade	grade	NOUN
gs-3688	49	32	methanol	methanol	NOUN
gs-3688	49	33	of	of	ADP
gs-3688	49	34	analytical	analytical	ADJ
gs-3688	49	35	grade	grade	NOUN
gs-3688	49	36	was	be	AUX
gs-3688	49	37	purchased	purchase	VERB
gs-3688	49	38	from	from	ADP
gs-3688	49	39	merck	merck	PROPN
gs-3688	49	40	&	&	CCONJ
gs-3688	49	41	co.	co.	PROPN
gs-3688	49	42	ultrapure	ultrapure	NOUN
gs-3688	49	43	water	water	NOUN
gs-3688	49	44	for	for	ADP
gs-3688	49	45	hplc	hplc	NOUN
gs-3688	49	46	analysis	analysis	NOUN
gs-3688	49	47	was	be	AUX
gs-3688	49	48	obtained	obtain	VERB
gs-3688	49	49	from	from	ADP
gs-3688	49	50	a	a	DET
gs-3688	49	51	millipore	millipore	NOUN
gs-3688	49	52	classic	classic	ADJ
gs-3688	49	53	purification	purification	NOUN
gs-3688	49	54	system	system	NOUN
gs-3688	49	55	.	.	PUNCT
gs-3688	50	1	berberine	berberine	NOUN
gs-3688	50	2	(	(	PUNCT
gs-3688	50	3	hplc	hplc	PROPN
gs-3688	50	4	99.0	99.0	NUM
gs-3688	50	5	%	%	NOUN
gs-3688	50	6	.	.	PUNCT
gs-3688	50	7	)	)	PUNCT
gs-3688	50	8	has	have	AUX
gs-3688	50	9	been	be	AUX
gs-3688	50	10	purchased	purchase	VERB
gs-3688	50	11	from	from	ADP
gs-3688	50	12	sigma	sigma	PROPN
gs-3688	50	13	ltd	ltd	PROPN
gs-3688	50	14	.	.	PROPN
gs-3688	50	15	figure	figure	NOUN
gs-3688	50	16	2	2	NUM
gs-3688	50	17	.	.	PUNCT
gs-3688	50	18	structure	structure	NOUN
gs-3688	50	19	of	of	ADP
gs-3688	50	20	berberine	berberine	NOUN
gs-3688	50	21	identification	identification	NOUN
gs-3688	50	22	of	of	ADP
gs-3688	50	23	berberine	berberine	NOUN
gs-3688	50	24	was	be	AUX
gs-3688	50	25	realized	realize	VERB
gs-3688	50	26	using	use	VERB
gs-3688	50	27	the	the	DET
gs-3688	50	28	lc	lc	NOUN
gs-3688	50	29	-	-	PUNCT
gs-3688	50	30	ms	ms	PROPN
gs-3688	50	31	spectra	spectra	NOUN
gs-3688	50	32	with	with	ADP
gs-3688	50	33	comparison	comparison	NOUN
gs-3688	50	34	the	the	DET
gs-3688	50	35	reference	reference	NOUN
gs-3688	50	36	data[31	data[31	X
gs-3688	50	37	]	]	X
gs-3688	50	38	.	.	PUNCT
gs-3688	51	1	2.5	2.5	NUM
gs-3688	51	2	.	.	PUNCT
gs-3688	51	3	chromatographic	chromatographic	ADJ
gs-3688	51	4	instrument	instrument	NOUN
gs-3688	51	5	and	and	CCONJ
gs-3688	51	6	conditions	condition	NOUN
gs-3688	51	7	:	:	PUNCT
gs-3688	51	8	the	the	DET
gs-3688	51	9	agilent	agilent	PROPN
gs-3688	51	10	technologies	technologies	PROPN
gs-3688	51	11	model	model	VERB
gs-3688	51	12	1260	1260	NUM
gs-3688	51	13	liquid	liquid	ADJ
gs-3688	51	14	chromatography	chromatography	NOUN
gs-3688	51	15	,	,	PUNCT
gs-3688	51	16	which	which	PRON
gs-3688	51	17	was	be	AUX
gs-3688	51	18	part	part	NOUN
gs-3688	51	19	of	of	ADP
gs-3688	51	20	the	the	DET
gs-3688	51	21	hplc	hplc	NOUN
gs-3688	51	22	system	system	NOUN
gs-3688	51	23	,	,	PUNCT
gs-3688	51	24	has	have	VERB
gs-3688	51	25	a	a	DET
gs-3688	51	26	photodiode	photodiode	NOUN
gs-3688	51	27	array	array	NOUN
gs-3688	51	28	detector	detector	NOUN
gs-3688	51	29	(	(	PUNCT
gs-3688	51	30	dad	dad	PROPN
gs-3688	51	31	)	)	PUNCT
gs-3688	51	32	,	,	PUNCT
gs-3688	51	33	an	an	DET
gs-3688	51	34	autosampler	autosampler	NOUN
gs-3688	51	35	,	,	PUNCT
gs-3688	51	36	a	a	DET
gs-3688	51	37	quaternary	quaternary	ADJ
gs-3688	51	38	pump	pump	NOUN
gs-3688	51	39	,	,	PUNCT
gs-3688	51	40	a	a	DET
gs-3688	51	41	vacuum	vacuum	NOUN
gs-3688	51	42	degasser	degasser	NOUN
gs-3688	51	43	,	,	PUNCT
gs-3688	51	44	and	and	CCONJ
gs-3688	51	45	an	an	DET
gs-3688	51	46	ms	ms	PROPN
gs-3688	51	47	.	.	PROPN
gs-3688	51	48	computer	computer	NOUN
gs-3688	51	49	software	software	NOUN
gs-3688	51	50	:	:	PUNCT
gs-3688	51	51	chemstation	chemstation	NOUN
gs-3688	51	52	.	.	PUNCT
gs-3688	52	1	an	an	DET
gs-3688	52	2	eclipse	eclipse	NOUN
gs-3688	52	3	plus	plus	CCONJ
gs-3688	52	4	c-18	c-18	PROPN
gs-3688	52	5	(	(	PUNCT
gs-3688	52	6	250	250	NUM
gs-3688	52	7	x	x	SYM
gs-3688	52	8	4.6	4.6	NUM
gs-3688	52	9	x	x	SYM
gs-3688	52	10	5	5	NUM
gs-3688	52	11	µm	µm	NOUN
gs-3688	52	12	)	)	PUNCT
gs-3688	52	13	was	be	AUX
gs-3688	52	14	used	use	VERB
gs-3688	52	15	to	to	PART
gs-3688	52	16	accomplish	accomplish	VERB
gs-3688	52	17	the	the	DET
gs-3688	52	18	chromatographic	chromatographic	ADJ
gs-3688	52	19	separation	separation	NOUN
gs-3688	52	20	.	.	PUNCT
gs-3688	53	1	all	all	DET
gs-3688	53	2	separations	separation	NOUN
gs-3688	53	3	were	be	AUX
gs-3688	53	4	carried	carry	VERB
gs-3688	53	5	out	out	ADP
gs-3688	53	6	at	at	ADP
gs-3688	53	7	20	20	NUM
gs-3688	53	8	°	°	NOUN
gs-3688	53	9	c	c	NOUN
gs-3688	53	10	.	.	PUNCT
gs-3688	54	1	the	the	DET
gs-3688	54	2	mobile	mobile	ADJ
gs-3688	54	3	phase	phase	NOUN
gs-3688	54	4	was	be	AUX
gs-3688	54	5	made	make	VERB
gs-3688	54	6	up	up	ADP
gs-3688	54	7	of	of	ADP
gs-3688	54	8	methanol	methanol	NOUN
gs-3688	54	9	(	(	PUNCT
gs-3688	54	10	0.1	0.1	NUM
gs-3688	54	11	%	%	NOUN
gs-3688	54	12	formic	formic	ADJ
gs-3688	54	13	acid	acid	NOUN
gs-3688	54	14	):	):	PUNCT
gs-3688	54	15	water	water	NOUN
gs-3688	54	16	(	(	PUNCT
gs-3688	54	17	0.1	0.1	NUM
gs-3688	54	18	formic	formic	NOUN
gs-3688	54	19	acid	acid	NOUN
gs-3688	54	20	)	)	PUNCT
gs-3688	54	21	35:65	35:65	NUM
gs-3688	54	22	v	v	NOUN
gs-3688	54	23	/	/	SYM
gs-3688	54	24	v	v	NOUN
gs-3688	54	25	;	;	PUNCT
gs-3688	54	26	the	the	DET
gs-3688	54	27	flow	flow	NOUN
gs-3688	54	28	rate	rate	NOUN
gs-3688	54	29	was	be	AUX
gs-3688	54	30	1	1	NUM
gs-3688	54	31	ml	ml	NOUN
gs-3688	54	32	/	/	SYM
gs-3688	54	33	min	min	NOUN
gs-3688	54	34	,	,	PUNCT
gs-3688	54	35	and	and	CCONJ
gs-3688	54	36	the	the	DET
gs-3688	54	37	injection	injection	NOUN
gs-3688	54	38	volume	volume	NOUN
gs-3688	54	39	was	be	AUX
gs-3688	54	40	10	10	NUM
gs-3688	54	41	μl	μl	NOUN
gs-3688	54	42	.	.	PUNCT
gs-3688	55	1	all	all	DET
gs-3688	55	2	peaks	peak	NOUN
gs-3688	55	3	'	'	PART
gs-3688	55	4	uv	uv	NOUN
gs-3688	55	5	spectra	spectra	NOUN
gs-3688	55	6	were	be	AUX
gs-3688	55	7	captured	capture	VERB
gs-3688	55	8	within	within	ADP
gs-3688	55	9	the	the	DET
gs-3688	55	10	detection	detection	NOUN
gs-3688	55	11	range	range	NOUN
gs-3688	55	12	of	of	ADP
gs-3688	55	13	200–400	200–400	NUM
gs-3688	55	14	nm	nm	NOUN
gs-3688	55	15	.	.	PUNCT
gs-3688	56	1	the	the	DET
gs-3688	56	2	sole	sole	ADJ
gs-3688	56	3	wavelength	wavelength	NOUN
gs-3688	56	4	used	use	VERB
gs-3688	56	5	for	for	ADP
gs-3688	56	6	quantification	quantification	NOUN
gs-3688	56	7	was	be	AUX
gs-3688	56	8	346	346	NUM
gs-3688	56	9	nm	nm	NOUN
gs-3688	56	10	.	.	PUNCT
gs-3688	57	1	2.6	2.6	NUM
gs-3688	57	2	.	.	PUNCT
gs-3688	57	3	preparation	preparation	NOUN
gs-3688	57	4	of	of	ADP
gs-3688	57	5	standard	standard	ADJ
gs-3688	57	6	solution	solution	NOUN
gs-3688	57	7	:	:	PUNCT
gs-3688	57	8	to	to	PART
gs-3688	57	9	reach	reach	VERB
gs-3688	57	10	a	a	DET
gs-3688	57	11	final	final	ADJ
gs-3688	57	12	concentration	concentration	NOUN
gs-3688	57	13	of	of	ADP
gs-3688	57	14	1.0	1.0	NUM
gs-3688	57	15	mg	mg	NUM
gs-3688	57	16	/	/	SYM
gs-3688	57	17	ml	ml	PROPN
gs-3688	57	18	,	,	PUNCT
gs-3688	57	19	a	a	DET
gs-3688	57	20	standard	standard	ADJ
gs-3688	57	21	solution	solution	NOUN
gs-3688	57	22	of	of	ADP
gs-3688	57	23	berberine	berberine	NOUN
gs-3688	57	24	was	be	AUX
gs-3688	57	25	made	make	VERB
gs-3688	57	26	in	in	ADP
gs-3688	57	27	methanol	methanol	NOUN
gs-3688	57	28	.	.	PUNCT
gs-3688	58	1	to	to	PART
gs-3688	58	2	achieve	achieve	VERB
gs-3688	58	3	different	different	ADJ
gs-3688	58	4	concentration	concentration	NOUN
gs-3688	58	5	levels	level	NOUN
gs-3688	58	6	(	(	PUNCT
gs-3688	58	7	0.002	0.002	NUM
gs-3688	58	8	-	-	SYM
gs-3688	58	9	1.0	1.0	NUM
gs-3688	58	10	mg	mg	NUM
gs-3688	58	11	/	/	SYM
gs-3688	58	12	ml	ml	NOUN
gs-3688	58	13	)	)	PUNCT
gs-3688	58	14	,	,	PUNCT
gs-3688	58	15	several	several	ADJ
gs-3688	58	16	working	work	VERB
gs-3688	58	17	solutions	solution	NOUN
gs-3688	58	18	of	of	ADP
gs-3688	58	19	berberine	berberine	NOUN
gs-3688	58	20	(	(	PUNCT
gs-3688	58	21	n=5	n=5	PROPN
gs-3688	58	22	)	)	PUNCT
gs-3688	58	23	were	be	AUX
gs-3688	58	24	made	make	VERB
gs-3688	58	25	.	.	PUNCT
gs-3688	59	1	a	a	DET
gs-3688	59	2	10.0	10.0	NUM
gs-3688	59	3	ml	ml	NOUN
gs-3688	59	4	volumetric	volumetric	NOUN
gs-3688	59	5	flask	flask	NOUN
gs-3688	59	6	was	be	AUX
gs-3688	59	7	filled	fill	VERB
gs-3688	59	8	with	with	ADP
gs-3688	59	9	the	the	DET
gs-3688	59	10	proper	proper	ADJ
gs-3688	59	11	volume	volume	NOUN
gs-3688	59	12	of	of	ADP
gs-3688	59	13	berberine	berberine	NOUN
gs-3688	59	14	solution	solution	NOUN
gs-3688	59	15	,	,	PUNCT
gs-3688	59	16	and	and	CCONJ
gs-3688	59	17	the	the	DET
gs-3688	59	18	volume	volume	NOUN
gs-3688	59	19	was	be	AUX
gs-3688	59	20	adjusted	adjust	VERB
gs-3688	59	21	to	to	ADP
gs-3688	59	22	10.0	10.0	NUM
gs-3688	59	23	ml	ml	NOUN
gs-3688	59	24	using	use	VERB
gs-3688	59	25	mobile	mobile	ADJ
gs-3688	59	26	phase	phase	NOUN
gs-3688	59	27	.	.	PUNCT
gs-3688	60	1	prior	prior	ADV
gs-3688	60	2	to	to	ADP
gs-3688	60	3	hplc	hplc	NOUN
gs-3688	60	4	analysis	analysis	NOUN
gs-3688	60	5	,	,	PUNCT
gs-3688	60	6	all	all	DET
gs-3688	60	7	prepared	prepare	VERB
gs-3688	60	8	standard	standard	ADJ
gs-3688	60	9	solutions	solution	NOUN
gs-3688	60	10	were	be	AUX
gs-3688	60	11	passed	pass	VERB
gs-3688	60	12	through	through	ADP
gs-3688	60	13	a	a	DET
gs-3688	60	14	0.45	0.45	NUM
gs-3688	60	15	μm	μm	NOUN
gs-3688	60	16	membrane	membrane	NOUN
gs-3688	60	17	filter	filter	NOUN
gs-3688	60	18	(	(	PUNCT
gs-3688	60	19	millipore	millipore	NOUN
gs-3688	60	20	)	)	PUNCT
gs-3688	60	21	.	.	PUNCT
gs-3688	61	1	2.7	2.7	NUM
gs-3688	61	2	.	.	PUNCT
gs-3688	61	3	preparation	preparation	NOUN
gs-3688	61	4	of	of	ADP
gs-3688	61	5	sample	sample	NOUN
gs-3688	61	6	solution	solution	NOUN
gs-3688	61	7	:	:	PUNCT
gs-3688	61	8	involved	involve	VERB
gs-3688	61	9	adding	add	VERB
gs-3688	61	10	20.0	20.0	NUM
gs-3688	61	11	mg	mg	NOUN
gs-3688	61	12	of	of	ADP
gs-3688	61	13	m.	m.	PROPN
gs-3688	61	14	aquifolium	aquifolium	PROPN
gs-3688	61	15	crude	crude	PROPN
gs-3688	61	16	extract	extract	NOUN
gs-3688	61	17	(	(	PUNCT
gs-3688	61	18	bought	buy	VERB
gs-3688	61	19	from	from	ADP
gs-3688	61	20	the	the	DET
gs-3688	61	21	institute	institute	NOUN
gs-3688	61	22	of	of	ADP
gs-3688	61	23	pharmacochemistry	pharmacochemistry	PROPN
gs-3688	61	24	in	in	ADP
gs-3688	61	25	tbilisi	tbilisi	PROPN
gs-3688	61	26	,	,	PUNCT
gs-3688	61	27	georgia	georgia	PROPN
gs-3688	61	28	)	)	PUNCT
gs-3688	61	29	to	to	ADP
gs-3688	61	30	a	a	DET
gs-3688	61	31	100	100	NUM
gs-3688	61	32	ml	ml	NOUN
gs-3688	61	33	volumetric	volumetric	ADJ
gs-3688	61	34	flask	flask	NOUN
gs-3688	61	35	,	,	PUNCT
gs-3688	61	36	dissolving	dissolve	VERB
gs-3688	61	37	it	it	PRON
gs-3688	61	38	in	in	ADP
gs-3688	61	39	methanol	methanol	NOUN
gs-3688	61	40	,	,	PUNCT
gs-3688	61	41	and	and	CCONJ
gs-3688	61	42	then	then	ADV
gs-3688	61	43	adjusting	adjust	VERB
gs-3688	61	44	the	the	DET
gs-3688	61	45	volume	volume	NOUN
gs-3688	61	46	to	to	ADP
gs-3688	61	47	100	100	NUM
gs-3688	61	48	ml	ml	NOUN
gs-3688	61	49	using	use	VERB
gs-3688	61	50	methanol	methanol	NOUN
gs-3688	61	51	.	.	PUNCT
gs-3688	62	1	a	a	DET
gs-3688	62	2	syringe	syringe	NOUN
gs-3688	62	3	filter	filter	NOUN
gs-3688	62	4	(	(	PUNCT
gs-3688	62	5	0.45	0.45	NUM
gs-3688	62	6	mm	mm	PROPN
gs-3688	62	7	millipore	millipore	PROPN
gs-3688	62	8	)	)	PUNCT
gs-3688	62	9	was	be	AUX
gs-3688	62	10	then	then	ADV
gs-3688	62	11	used	use	VERB
gs-3688	62	12	to	to	PART
gs-3688	62	13	filter	filter	VERB
gs-3688	62	14	2	2	NUM
gs-3688	62	15	ml	ml	NOUN
gs-3688	62	16	of	of	ADP
gs-3688	62	17	each	each	DET
gs-3688	62	18	solution	solution	NOUN
gs-3688	62	19	into	into	ADP
gs-3688	62	20	an	an	DET
gs-3688	62	21	hplc	hplc	NOUN
gs-3688	62	22	vial	vial	NOUN
gs-3688	62	23	.	.	PUNCT
gs-3688	63	1	georgian	georgian	ADJ
gs-3688	63	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3688	63	3	მეცნიერები	მეცნიერები	NOUN
gs-3688	63	4	ტ.	ტ.	VERB
gs-3688	63	5	7	7	NUM
gs-3688	63	6	n	n	DET
gs-3688	63	7	2	2	NUM
gs-3688	63	8	,	,	PUNCT
gs-3688	63	9	2025	2025	NUM
gs-3688	63	10	301	301	NUM
gs-3688	63	11	3	3	NUM
gs-3688	63	12	.	.	NOUN
gs-3688	63	13	results	result	NOUN
gs-3688	63	14	and	and	CCONJ
gs-3688	63	15	discussion	discussion	NOUN
gs-3688	63	16	3.1	3.1	NUM
gs-3688	63	17	assay	assay	NOUN
gs-3688	63	18	and	and	CCONJ
gs-3688	63	19	validation	validation	NOUN
gs-3688	63	20	:	:	PUNCT
gs-3688	63	21	the	the	DET
gs-3688	63	22	procedure	procedure	NOUN
gs-3688	63	23	was	be	AUX
gs-3688	63	24	tested	test	VERB
gs-3688	63	25	on	on	ADP
gs-3688	63	26	m.	m.	NOUN
gs-3688	63	27	aquifolium	aquifolium	PROPN
gs-3688	63	28	crude	crude	PROPN
gs-3688	63	29	extract	extract	NOUN
gs-3688	63	30	in	in	ADP
gs-3688	63	31	accordance	accordance	NOUN
gs-3688	63	32	with	with	ADP
gs-3688	63	33	ich	ich	NOUN
gs-3688	63	34	recommendations	recommendation	NOUN
gs-3688	63	35	(	(	PUNCT
gs-3688	63	36	ich	ich	NOUN
gs-3688	63	37	-	-	PUNCT
gs-3688	63	38	q2	q2	NOUN
gs-3688	63	39	(	(	PUNCT
gs-3688	63	40	r1	r1	PROPN
gs-3688	63	41	)	)	PUNCT
gs-3688	63	42	(	(	PUNCT
gs-3688	63	43	2005	2005	NUM
gs-3688	63	44	)	)	PUNCT
gs-3688	63	45	geneva	geneva	PROPN
gs-3688	63	46	.	.	PUNCT
gs-3688	64	1	for	for	ADP
gs-3688	64	2	berberine	berberine	NOUN
gs-3688	64	3	,	,	PUNCT
gs-3688	64	4	the	the	DET
gs-3688	64	5	hplc	hplc	NOUN
gs-3688	64	6	method	method	NOUN
gs-3688	64	7	's	's	PART
gs-3688	64	8	linearity	linearity	NOUN
gs-3688	64	9	was	be	AUX
gs-3688	64	10	tested	test	VERB
gs-3688	64	11	.	.	PUNCT
gs-3688	65	1	for	for	ADP
gs-3688	65	2	every	every	DET
gs-3688	65	3	concentration	concentration	NOUN
gs-3688	65	4	,	,	PUNCT
gs-3688	65	5	five	five	NUM
gs-3688	65	6	distinct	distinct	ADJ
gs-3688	65	7	concentrations	concentration	NOUN
gs-3688	65	8	were	be	AUX
gs-3688	65	9	made	make	VERB
gs-3688	65	10	and	and	CCONJ
gs-3688	65	11	examined	examine	VERB
gs-3688	65	12	in	in	ADP
gs-3688	65	13	triplicate	triplicate	NOUN
gs-3688	65	14	.	.	PUNCT
gs-3688	66	1	berberine	berberine	PROPN
gs-3688	66	2	has	have	VERB
gs-3688	66	3	a	a	DET
gs-3688	66	4	concentration	concentration	NOUN
gs-3688	66	5	range	range	NOUN
gs-3688	66	6	of	of	ADP
gs-3688	66	7	0.002	0.002	NUM
gs-3688	66	8	to	to	ADP
gs-3688	66	9	1.0	1.0	NUM
gs-3688	66	10	mg	mg	PROPN
gs-3688	66	11	ml-1	ml-1	PROPN
gs-3688	66	12	.	.	PROPN
gs-3688	67	1	peak	peak	NOUN
gs-3688	67	2	regions	region	NOUN
gs-3688	67	3	were	be	AUX
gs-3688	67	4	plotted	plot	VERB
gs-3688	67	5	against	against	ADP
gs-3688	67	6	concentrations	concentration	NOUN
gs-3688	67	7	to	to	PART
gs-3688	67	8	create	create	VERB
gs-3688	67	9	calibration	calibration	NOUN
gs-3688	67	10	curves	curve	NOUN
gs-3688	67	11	.	.	PUNCT
gs-3688	68	1	using	use	VERB
gs-3688	68	2	least	least	ADJ
gs-3688	68	3	squares	square	NOUN
gs-3688	68	4	regression	regression	NOUN
gs-3688	68	5	,	,	PUNCT
gs-3688	68	6	the	the	DET
gs-3688	68	7	slope	slope	NOUN
gs-3688	68	8	,	,	PUNCT
gs-3688	68	9	y	y	PROPN
gs-3688	68	10	-	-	PUNCT
gs-3688	68	11	intercept	intercept	NOUN
gs-3688	68	12	,	,	PUNCT
gs-3688	68	13	and	and	CCONJ
gs-3688	68	14	coefficient	coefficient	NOUN
gs-3688	68	15	of	of	ADP
gs-3688	68	16	correlation	correlation	NOUN
gs-3688	68	17	(	(	PUNCT
gs-3688	68	18	r2	r2	PROPN
gs-3688	68	19	)	)	PUNCT
gs-3688	68	20	were	be	AUX
gs-3688	68	21	computed	compute	VERB
gs-3688	68	22	in	in	ADP
gs-3688	68	23	order	order	NOUN
gs-3688	68	24	to	to	PART
gs-3688	68	25	evaluate	evaluate	VERB
gs-3688	68	26	the	the	DET
gs-3688	68	27	linearity	linearity	NOUN
gs-3688	68	28	.	.	PUNCT
gs-3688	69	1	the	the	DET
gs-3688	69	2	concentrations	concentration	NOUN
gs-3688	69	3	that	that	PRON
gs-3688	69	4	resulted	result	VERB
gs-3688	69	5	in	in	ADP
gs-3688	69	6	signal	signal	NOUN
gs-3688	69	7	-	-	PUNCT
gs-3688	69	8	to	to	ADP
gs-3688	69	9	-	-	PUNCT
gs-3688	69	10	noise	noise	NOUN
gs-3688	69	11	ratios	ratio	NOUN
gs-3688	69	12	of	of	ADP
gs-3688	69	13	3:1	3:1	NUM
gs-3688	69	14	and	and	CCONJ
gs-3688	69	15	10:1	10:1	NUM
gs-3688	69	16	,	,	PUNCT
gs-3688	69	17	respectively	respectively	ADV
gs-3688	69	18	,	,	PUNCT
gs-3688	69	19	were	be	AUX
gs-3688	69	20	the	the	DET
gs-3688	69	21	limits	limit	NOUN
gs-3688	69	22	of	of	ADP
gs-3688	69	23	detection	detection	NOUN
gs-3688	69	24	and	and	CCONJ
gs-3688	69	25	quantification	quantification	NOUN
gs-3688	69	26	.	.	PUNCT
gs-3688	70	1	figure	figure	NOUN
gs-3688	70	2	3	3	NUM
gs-3688	70	3	.	.	PUNCT
gs-3688	71	1	hplc	hplc	NOUN
gs-3688	71	2	profile	profile	NOUN
gs-3688	71	3	of	of	ADP
gs-3688	71	4	a	a	DET
gs-3688	71	5	)	)	PUNCT
gs-3688	71	6	berberine	berberine	NOUN
gs-3688	71	7	and	and	CCONJ
gs-3688	71	8	total	total	ADJ
gs-3688	71	9	alkaloids	alkaloid	NOUN
gs-3688	71	10	from	from	ADP
gs-3688	71	11	the	the	DET
gs-3688	71	12	aerial	aerial	ADJ
gs-3688	71	13	parts	part	NOUN
gs-3688	71	14	b	b	NOUN
gs-3688	71	15	)	)	PUNCT
gs-3688	71	16	m.	m.	NOUN
gs-3688	71	17	aquifolium	aquifolium	PROPN
gs-3688	71	18	.	.	PUNCT
gs-3688	72	1	figure	figure	NOUN
gs-3688	72	2	4	4	NUM
gs-3688	72	3	.	.	PUNCT
gs-3688	72	4	calibration	calibration	NOUN
gs-3688	72	5	curve	curve	NOUN
gs-3688	72	6	and	and	CCONJ
gs-3688	72	7	linearity	linearity	NOUN
gs-3688	72	8	of	of	ADP
gs-3688	72	9	berberine	berberine	NOUN
gs-3688	72	10	.	.	PUNCT
gs-3688	73	1	both	both	DET
gs-3688	73	2	intraand	intraand	ADP
gs-3688	73	3	inter	inter	ADJ
gs-3688	73	4	-	-	ADJ
gs-3688	73	5	day	day	ADJ
gs-3688	73	6	precision	precision	NOUN
gs-3688	73	7	were	be	AUX
gs-3688	73	8	used	use	VERB
gs-3688	73	9	to	to	PART
gs-3688	73	10	assess	assess	VERB
gs-3688	73	11	the	the	DET
gs-3688	73	12	method	method	NOUN
gs-3688	73	13	's	's	PART
gs-3688	73	14	accuracy	accuracy	NOUN
gs-3688	73	15	.	.	PUNCT
gs-3688	74	1	six	six	NUM
gs-3688	74	2	sample	sample	NOUN
gs-3688	74	3	solutions	solution	NOUN
gs-3688	74	4	were	be	AUX
gs-3688	74	5	made	make	VERB
gs-3688	74	6	independently	independently	ADV
gs-3688	74	7	on	on	ADP
gs-3688	74	8	a	a	DET
gs-3688	74	9	single	single	ADJ
gs-3688	74	10	day	day	NOUN
gs-3688	74	11	,	,	PUNCT
gs-3688	74	12	and	and	CCONJ
gs-3688	74	13	their	their	PRON
gs-3688	74	14	analyses	analysis	NOUN
gs-3688	74	15	were	be	AUX
gs-3688	74	16	used	use	VERB
gs-3688	74	17	to	to	PART
gs-3688	74	18	calculate	calculate	VERB
gs-3688	74	19	intraday	intraday	PROPN
gs-3688	74	20	precision	precision	NOUN
gs-3688	74	21	.	.	PUNCT
gs-3688	75	1	the	the	DET
gs-3688	75	2	same	same	ADJ
gs-3688	75	3	process	process	NOUN
gs-3688	75	4	was	be	AUX
gs-3688	75	5	repeated	repeat	VERB
gs-3688	75	6	on	on	ADP
gs-3688	75	7	two	two	NUM
gs-3688	75	8	additional	additional	ADJ
gs-3688	75	9	days	day	NOUN
gs-3688	75	10	to	to	PART
gs-3688	75	11	assess	assess	VERB
gs-3688	75	12	inter	inter	ADJ
gs-3688	75	13	-	-	ADJ
gs-3688	75	14	day	day	ADJ
gs-3688	75	15	precision	precision	NOUN
gs-3688	75	16	.	.	PUNCT
gs-3688	76	1	for	for	ADP
gs-3688	76	2	every	every	DET
gs-3688	76	3	day	day	NOUN
gs-3688	76	4	,	,	PUNCT
gs-3688	76	5	the	the	DET
gs-3688	76	6	rsd	rsd	NOUN
gs-3688	76	7	(	(	PUNCT
gs-3688	76	8	relative	relative	ADJ
gs-3688	76	9	standard	standard	ADJ
gs-3688	76	10	deviation	deviation	NOUN
gs-3688	76	11	)	)	PUNCT
gs-3688	76	12	and	and	CCONJ
gs-3688	76	13	standard	standard	ADJ
gs-3688	76	14	deviation	deviation	NOUN
gs-3688	76	15	values	value	NOUN
gs-3688	76	16	were	be	AUX
gs-3688	76	17	computed	compute	VERB
gs-3688	76	18	.	.	PUNCT
gs-3688	77	1	the	the	DET
gs-3688	77	2	recovery	recovery	NOUN
gs-3688	77	3	test	test	NOUN
gs-3688	77	4	was	be	AUX
gs-3688	77	5	used	use	VERB
gs-3688	77	6	to	to	PART
gs-3688	77	7	assess	assess	VERB
gs-3688	77	8	the	the	DET
gs-3688	77	9	method	method	NOUN
gs-3688	77	10	's	's	PART
gs-3688	77	11	accuracy	accuracy	NOUN
gs-3688	77	12	.	.	PUNCT
gs-3688	78	1	to	to	PART
gs-3688	78	2	do	do	VERB
gs-3688	78	3	this	this	DET
gs-3688	78	4	,	,	PUNCT
gs-3688	78	5	known	known	ADJ
gs-3688	78	6	amounts	amount	NOUN
gs-3688	78	7	of	of	ADP
gs-3688	78	8	standard	standard	ADJ
gs-3688	78	9	solutions	solution	NOUN
gs-3688	78	10	containing	contain	VERB
gs-3688	78	11	berberine	berberine	NOUN
gs-3688	78	12	were	be	AUX
gs-3688	78	13	spiked	spike	VERB
gs-3688	78	14	into	into	ADP
gs-3688	78	15	the	the	DET
gs-3688	78	16	actual	actual	ADJ
gs-3688	78	17	samples	sample	NOUN
gs-3688	78	18	.	.	PUNCT
gs-3688	79	1	three	three	NUM
gs-3688	79	2	concentration	concentration	NOUN
gs-3688	79	3	levels	level	NOUN
gs-3688	79	4	(	(	PUNCT
gs-3688	79	5	50	50	NUM
gs-3688	79	6	,	,	PUNCT
gs-3688	79	7	100	100	NUM
gs-3688	79	8	,	,	PUNCT
gs-3688	79	9	and	and	CCONJ
gs-3688	79	10	150	150	NUM
gs-3688	79	11	%	%	NOUN
gs-3688	79	12	)	)	PUNCT
gs-3688	79	13	were	be	AUX
gs-3688	79	14	used	use	VERB
gs-3688	79	15	to	to	PART
gs-3688	79	16	prepare	prepare	VERB
gs-3688	79	17	the	the	DET
gs-3688	79	18	standard	standard	ADJ
gs-3688	79	19	solutions	solution	NOUN
gs-3688	79	20	.	.	PUNCT
gs-3688	80	1	samples	sample	NOUN
gs-3688	80	2	were	be	AUX
gs-3688	80	3	analyzed	analyze	VERB
gs-3688	80	4	in	in	ADP
gs-3688	80	5	triplicate	triplicate	NOUN
gs-3688	80	6	at	at	ADP
gs-3688	80	7	each	each	DET
gs-3688	80	8	level	level	NOUN
gs-3688	80	9	using	use	VERB
gs-3688	80	10	the	the	DET
gs-3688	80	11	chromatographic	chromatographic	ADJ
gs-3688	80	12	conditions	condition	NOUN
gs-3688	80	13	previously	previously	ADV
gs-3688	80	14	mentioned	mention	VERB
gs-3688	80	15	.	.	PUNCT
gs-3688	81	1	to	to	PART
gs-3688	81	2	obtain	obtain	VERB
gs-3688	81	3	a	a	DET
gs-3688	81	4	good	good	ADJ
gs-3688	81	5	resolution	resolution	NOUN
gs-3688	81	6	,	,	PUNCT
gs-3688	81	7	the	the	DET
gs-3688	81	8	hplc	hplc	NOUN
gs-3688	81	9	separation	separation	NOUN
gs-3688	81	10	conditions	condition	NOUN
gs-3688	81	11	were	be	AUX
gs-3688	81	12	improved	improve	VERB
gs-3688	81	13	.	.	PUNCT
gs-3688	82	1	the	the	DET
gs-3688	82	2	reverse	reverse	ADJ
gs-3688	82	3	phase	phase	NOUN
gs-3688	82	4	column	column	NOUN
gs-3688	82	5	eclipse	eclipse	NOUN
gs-3688	82	6	plus	plus	CCONJ
gs-3688	82	7	c-18	c-18	PROPN
gs-3688	82	8	(	(	PUNCT
gs-3688	82	9	250	250	NUM
gs-3688	82	10	x	x	SYM
gs-3688	82	11	4.6	4.6	NUM
gs-3688	82	12	x	x	SYM
gs-3688	82	13	5	5	NUM
gs-3688	82	14	µm	µm	NOUN
gs-3688	82	15	)	)	PUNCT
gs-3688	82	16	produced	produce	VERB
gs-3688	82	17	the	the	DET
gs-3688	82	18	best	good	ADJ
gs-3688	82	19	separation	separation	NOUN
gs-3688	82	20	of	of	ADP
gs-3688	82	21	the	the	DET
gs-3688	82	22	m.	m.	NOUN
gs-3688	82	23	aquifolium	aquifolium	PROPN
gs-3688	82	24	crude	crude	ADJ
gs-3688	82	25	extract	extract	NOUN
gs-3688	82	26	.	.	PUNCT
gs-3688	83	1	the	the	DET
gs-3688	83	2	y	y	PROPN
gs-3688	83	3	=	=	SYM
gs-3688	83	4	11989x	11989x	NUM
gs-3688	83	5	+	+	CCONJ
gs-3688	83	6	4.9007	4.9007	NUM
gs-3688	83	7	r²	r²	NOUN
gs-3688	83	8	=	=	PUNCT
gs-3688	83	9	0.9992	0.9992	NUM
gs-3688	83	10	0	0	NUM
gs-3688	83	11	1000	1000	NUM
gs-3688	83	12	2000	2000	NUM
gs-3688	83	13	3000	3000	NUM
gs-3688	83	14	4000	4000	NUM
gs-3688	83	15	5000	5000	NUM
gs-3688	83	16	6000	6000	NUM
gs-3688	83	17	7000	7000	NUM
gs-3688	83	18	0	0	NUM
gs-3688	83	19	0.1	0.1	NUM
gs-3688	83	20	0.2	0.2	NUM
gs-3688	83	21	0.3	0.3	NUM
gs-3688	83	22	0.4	0.4	NUM
gs-3688	83	23	0.5	0.5	NUM
gs-3688	83	24	0.6	0.6	NUM
gs-3688	83	25	a	a	DET
gs-3688	83	26	b	b	NOUN
gs-3688	83	27	georgian	georgian	ADJ
gs-3688	83	28	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3688	83	29	მეცნიერები	მეცნიერები	NOUN
gs-3688	83	30	ტ.	ტ.	VERB
gs-3688	83	31	7	7	NUM
gs-3688	83	32	n	n	DET
gs-3688	83	33	2	2	NUM
gs-3688	83	34	,	,	PUNCT
gs-3688	83	35	2025	2025	NUM
gs-3688	83	36	302	302	NUM
gs-3688	83	37	effect	effect	NOUN
gs-3688	83	38	of	of	ADP
gs-3688	83	39	the	the	DET
gs-3688	83	40	mobile	mobile	ADJ
gs-3688	83	41	phase	phase	NOUN
gs-3688	83	42	was	be	AUX
gs-3688	83	43	investigated	investigate	VERB
gs-3688	83	44	in	in	ADP
gs-3688	83	45	order	order	NOUN
gs-3688	83	46	to	to	PART
gs-3688	83	47	produce	produce	VERB
gs-3688	83	48	an	an	DET
gs-3688	83	49	ideal	ideal	ADJ
gs-3688	83	50	resolution	resolution	NOUN
gs-3688	83	51	.	.	PUNCT
gs-3688	84	1	a	a	DET
gs-3688	84	2	mobile	mobile	ADJ
gs-3688	84	3	phase	phase	NOUN
gs-3688	84	4	consisting	consist	VERB
gs-3688	84	5	of	of	ADP
gs-3688	84	6	methanol	methanol	NOUN
gs-3688	84	7	(	(	PUNCT
gs-3688	84	8	0.1	0.1	NUM
gs-3688	84	9	%	%	NOUN
gs-3688	84	10	formic	formic	ADJ
gs-3688	84	11	acid	acid	NOUN
gs-3688	84	12	):	):	PUNCT
gs-3688	84	13	water	water	NOUN
gs-3688	84	14	(	(	PUNCT
gs-3688	84	15	0.1	0.1	NUM
gs-3688	84	16	formic	formic	NOUN
gs-3688	84	17	acid	acid	NOUN
gs-3688	84	18	)	)	PUNCT
gs-3688	84	19	35:65	35:65	NUM
gs-3688	84	20	v	v	NOUN
gs-3688	84	21	/	/	SYM
gs-3688	84	22	v	v	NOUN
gs-3688	84	23	was	be	AUX
gs-3688	84	24	used	use	VERB
gs-3688	84	25	to	to	PART
gs-3688	84	26	detect	detect	VERB
gs-3688	84	27	a	a	DET
gs-3688	84	28	sufficient	sufficient	ADJ
gs-3688	84	29	separation	separation	NOUN
gs-3688	84	30	;	;	PUNCT
gs-3688	84	31	a	a	DET
gs-3688	84	32	berberine	berberine	NOUN
gs-3688	84	33	solution	solution	NOUN
gs-3688	84	34	was	be	AUX
gs-3688	84	35	made	make	VERB
gs-3688	84	36	in	in	ADP
gs-3688	84	37	methanol	methanol	NOUN
gs-3688	84	38	.	.	PUNCT
gs-3688	85	1	10.3	10.3	NUM
gs-3688	85	2	minutes	minute	NOUN
gs-3688	85	3	was	be	AUX
gs-3688	85	4	the	the	DET
gs-3688	85	5	recorded	record	VERB
gs-3688	85	6	retention	retention	NOUN
gs-3688	85	7	time	time	NOUN
gs-3688	85	8	for	for	ADP
gs-3688	85	9	berberine	berberine	NOUN
gs-3688	85	10	.	.	PUNCT
gs-3688	86	1	a	a	DET
gs-3688	86	2	suitable	suitable	ADJ
gs-3688	86	3	chromatographic	chromatographic	ADJ
gs-3688	86	4	baseline	baseline	NOUN
gs-3688	86	5	and	and	CCONJ
gs-3688	86	6	adequate	adequate	ADJ
gs-3688	86	7	sensitivity	sensitivity	NOUN
gs-3688	86	8	were	be	AUX
gs-3688	86	9	demonstrated	demonstrate	VERB
gs-3688	86	10	by	by	ADP
gs-3688	86	11	the	the	DET
gs-3688	86	12	measurement	measurement	NOUN
gs-3688	86	13	at	at	ADP
gs-3688	86	14	346	346	NUM
gs-3688	86	15	nm	nm	NOUN
gs-3688	86	16	.	.	PUNCT
gs-3688	87	1	consequently	consequently	ADV
gs-3688	87	2	,	,	PUNCT
gs-3688	87	3	under	under	ADP
gs-3688	87	4	ideal	ideal	ADJ
gs-3688	87	5	circumstances	circumstance	NOUN
gs-3688	87	6	,	,	PUNCT
gs-3688	87	7	a	a	DET
gs-3688	87	8	baseline	baseline	NOUN
gs-3688	87	9	separation	separation	NOUN
gs-3688	87	10	with	with	ADP
gs-3688	87	11	symmetrical	symmetrical	ADJ
gs-3688	87	12	,	,	PUNCT
gs-3688	87	13	crisp	crisp	ADJ
gs-3688	87	14	,	,	PUNCT
gs-3688	87	15	and	and	CCONJ
gs-3688	87	16	well	well	ADV
gs-3688	87	17	-	-	PUNCT
gs-3688	87	18	resolved	resolve	VERB
gs-3688	87	19	peaks	peak	NOUN
gs-3688	87	20	for	for	ADP
gs-3688	87	21	berberine	berberine	NOUN
gs-3688	87	22	was	be	AUX
gs-3688	87	23	accomplished	accomplish	VERB
gs-3688	87	24	in	in	ADP
gs-3688	87	25	30	30	NUM
gs-3688	87	26	minutes	minute	NOUN
gs-3688	87	27	.	.	PUNCT
gs-3688	88	1	the	the	DET
gs-3688	88	2	chromatogram	chromatogram	NOUN
gs-3688	88	3	reveals	reveal	VERB
gs-3688	88	4	the	the	DET
gs-3688	88	5	full	full	ADJ
gs-3688	88	6	baseline	baseline	NOUN
gs-3688	88	7	separation	separation	NOUN
gs-3688	88	8	of	of	ADP
gs-3688	88	9	berberine	berberine	NOUN
gs-3688	88	10	in	in	ADP
gs-3688	88	11	the	the	DET
gs-3688	88	12	m.	m.	NOUN
gs-3688	88	13	aquifolium	aquifolium	PROPN
gs-3688	88	14	crude	crude	ADJ
gs-3688	88	15	extract	extract	NOUN
gs-3688	88	16	.	.	PUNCT
gs-3688	89	1	the	the	DET
gs-3688	89	2	ich	ich	NOUN
gs-3688	89	3	recommendations	recommendation	NOUN
gs-3688	89	4	for	for	ADP
gs-3688	89	5	the	the	DET
gs-3688	89	6	validation	validation	NOUN
gs-3688	89	7	of	of	ADP
gs-3688	89	8	analytical	analytical	ADJ
gs-3688	89	9	methods	method	NOUN
gs-3688	89	10	were	be	AUX
gs-3688	89	11	followed	follow	VERB
gs-3688	89	12	in	in	ADP
gs-3688	89	13	the	the	DET
gs-3688	89	14	validation	validation	NOUN
gs-3688	89	15	of	of	ADP
gs-3688	89	16	this	this	DET
gs-3688	89	17	procedure	procedure	NOUN
gs-3688	89	18	.	.	PUNCT
gs-3688	90	1	by	by	ADP
gs-3688	90	2	comparing	compare	VERB
gs-3688	90	3	the	the	DET
gs-3688	90	4	retention	retention	NOUN
gs-3688	90	5	times	time	NOUN
gs-3688	90	6	of	of	ADP
gs-3688	90	7	berberine	berberine	NOUN
gs-3688	90	8	and	and	CCONJ
gs-3688	90	9	the	the	DET
gs-3688	90	10	crude	crude	ADJ
gs-3688	90	11	extract	extract	NOUN
gs-3688	90	12	of	of	ADP
gs-3688	90	13	m.	m.	NOUN
gs-3688	90	14	aquifolium	aquifolium	PROPN
gs-3688	90	15	,	,	PUNCT
gs-3688	90	16	excellent	excellent	ADJ
gs-3688	90	17	resolution	resolution	NOUN
gs-3688	90	18	was	be	AUX
gs-3688	90	19	seen	see	VERB
gs-3688	90	20	with	with	ADP
gs-3688	90	21	no	no	DET
gs-3688	90	22	interference	interference	NOUN
gs-3688	90	23	from	from	ADP
gs-3688	90	24	other	other	ADJ
gs-3688	90	25	substances	substance	NOUN
gs-3688	90	26	.	.	PUNCT
gs-3688	91	1	hplc	hplc	PROPN
gs-3688	91	2	was	be	AUX
gs-3688	91	3	used	use	VERB
gs-3688	91	4	to	to	PART
gs-3688	91	5	confirm	confirm	VERB
gs-3688	91	6	the	the	DET
gs-3688	91	7	peak	peak	NOUN
gs-3688	91	8	purity	purity	NOUN
gs-3688	91	9	(	(	PUNCT
gs-3688	91	10	agilent	agilent	PROPN
gs-3688	91	11	chemstation	chemstation	PROPN
gs-3688	91	12	software	software	PROPN
gs-3688	91	13	)	)	PUNCT
gs-3688	91	14	.	.	PUNCT
gs-3688	92	1	table	table	NOUN
gs-3688	92	2	1	1	NUM
gs-3688	92	3	shows	show	VERB
gs-3688	92	4	the	the	DET
gs-3688	92	5	mahonia	mahonia	NOUN
gs-3688	92	6	extract	extract	NOUN
gs-3688	92	7	's	's	PART
gs-3688	92	8	intraand	intraand	NOUN
gs-3688	92	9	inter	inter	ADJ
gs-3688	92	10	-	-	ADJ
gs-3688	92	11	day	day	ADJ
gs-3688	92	12	precision	precision	NOUN
gs-3688	92	13	results	result	NOUN
gs-3688	92	14	.	.	PUNCT
gs-3688	93	1	the	the	DET
gs-3688	93	2	method	method	NOUN
gs-3688	93	3	's	's	PART
gs-3688	93	4	precision	precision	NOUN
gs-3688	93	5	was	be	AUX
gs-3688	93	6	demonstrated	demonstrate	VERB
gs-3688	93	7	by	by	ADP
gs-3688	93	8	the	the	DET
gs-3688	93	9	intra	intra	ADJ
gs-3688	93	10	-	-	ADJ
gs-3688	93	11	day	day	ADJ
gs-3688	93	12	%	%	NOUN
gs-3688	93	13	rsd	rsd	NOUN
gs-3688	93	14	being	be	AUX
gs-3688	93	15	less	less	ADJ
gs-3688	93	16	than	than	ADP
gs-3688	93	17	2.4	2.4	NUM
gs-3688	93	18	%	%	NOUN
gs-3688	93	19	and	and	CCONJ
gs-3688	93	20	the	the	DET
gs-3688	93	21	inter	inter	ADJ
gs-3688	93	22	-	-	ADJ
gs-3688	93	23	day	day	ADJ
gs-3688	93	24	%	%	NOUN
gs-3688	93	25	rsd	rsd	NOUN
gs-3688	93	26	being	be	AUX
gs-3688	93	27	less	less	ADJ
gs-3688	93	28	than	than	ADP
gs-3688	93	29	3.3	3.3	NUM
gs-3688	93	30	%	%	NOUN
gs-3688	93	31	.	.	PUNCT
gs-3688	94	1	the	the	DET
gs-3688	94	2	calculated	calculate	VERB
gs-3688	94	3	recoveries	recovery	NOUN
gs-3688	94	4	varied	vary	VERB
gs-3688	94	5	between	between	ADP
gs-3688	94	6	99.68	99.68	NUM
gs-3688	94	7	and	and	CCONJ
gs-3688	94	8	100.28	100.28	NUM
gs-3688	94	9	%	%	NOUN
gs-3688	94	10	.	.	PUNCT
gs-3688	95	1	the	the	DET
gs-3688	95	2	detection	detection	NOUN
gs-3688	95	3	limit	limit	NOUN
gs-3688	95	4	was	be	AUX
gs-3688	95	5	0.5	0.5	NUM
gs-3688	95	6	μg	μg	NOUN
gs-3688	95	7	/	/	SYM
gs-3688	95	8	ml	ml	NOUN
gs-3688	95	9	.	.	NOUN
gs-3688	96	1	3.8	3.8	NUM
gs-3688	96	2	μg	μg	PROPN
gs-3688	96	3	ml-1	ml-1	PART
gs-3688	96	4	was	be	AUX
gs-3688	96	5	the	the	DET
gs-3688	96	6	quantitative	quantitative	ADJ
gs-3688	96	7	limit	limit	NOUN
gs-3688	96	8	.	.	PUNCT
gs-3688	97	1	berberine	berberine	NOUN
gs-3688	97	2	is	be	AUX
gs-3688	97	3	successfully	successfully	ADV
gs-3688	97	4	quantified	quantify	VERB
gs-3688	97	5	using	use	VERB
gs-3688	97	6	the	the	DET
gs-3688	97	7	established	establish	VERB
gs-3688	97	8	hplc	hplc	NOUN
gs-3688	97	9	method	method	NOUN
gs-3688	97	10	.	.	PUNCT
gs-3688	98	1	berberine	berberine	NOUN
gs-3688	98	2	should	should	AUX
gs-3688	98	3	make	make	VERB
gs-3688	98	4	up	up	ADP
gs-3688	98	5	at	at	ADV
gs-3688	98	6	least	least	ADV
gs-3688	98	7	2	2	NUM
gs-3688	98	8	%	%	NOUN
gs-3688	98	9	of	of	ADP
gs-3688	98	10	the	the	DET
gs-3688	98	11	overall	overall	ADJ
gs-3688	98	12	alkaloid	alkaloid	ADJ
gs-3688	98	13	concentration	concentration	NOUN
gs-3688	98	14	.	.	PUNCT
gs-3688	99	1	table	table	NOUN
gs-3688	99	2	i.	i.	PROPN
gs-3688	99	3	the	the	DET
gs-3688	99	4	results	result	NOUN
gs-3688	99	5	of	of	ADP
gs-3688	99	6	precision	precision	NOUN
gs-3688	99	7	measurements	measurement	NOUN
gs-3688	99	8	for	for	ADP
gs-3688	99	9	berberine	berberine	NOUN
gs-3688	99	10	within	within	ADP
gs-3688	99	11	and	and	CCONJ
gs-3688	99	12	between	between	ADP
gs-3688	99	13	days	day	NOUN
gs-3688	99	14	linearity	linearity	NOUN
gs-3688	99	15	range	range	VERB
gs-3688	99	16	0,005	0,005	NUM
gs-3688	99	17	-	-	SYM
gs-3688	99	18	1,0	1,0	NUM
gs-3688	99	19	mg	mg	NOUN
gs-3688	99	20	/	/	SYM
gs-3688	99	21	ml	ml	NOUN
gs-3688	99	22	calibration	calibration	NOUN
gs-3688	99	23	curve	curve	NOUN
gs-3688	99	24	r²	r²	NOUN
gs-3688	99	25	=	=	SYM
gs-3688	99	26	0.9992	0.9992	NUM
gs-3688	99	27	y=11989x	y=11989x	NOUN
gs-3688	99	28	+	+	CCONJ
gs-3688	99	29	4.9007	4.9007	NUM
gs-3688	99	30	accuracy	accuracy	NOUN
gs-3688	99	31	99,8±0,3	99,8±0,3	NUM
gs-3688	99	32	precision	precision	NOUN
gs-3688	99	33	intermediate	intermediate	ADJ
gs-3688	99	34	precision	precision	NOUN
gs-3688	100	1	%	%	INTJ
gs-3688	100	2	rsd	rsd	PROPN
gs-3688	100	3	i	i	PRON
gs-3688	100	4	day	day	NOUN
gs-3688	100	5	2.1	2.1	NUM
gs-3688	100	6	ii	ii	NOUN
gs-3688	100	7	day	day	NOUN
gs-3688	100	8	2.3	2.3	NUM
gs-3688	100	9	iii	iii	NOUN
gs-3688	100	10	day	day	NOUN
gs-3688	100	11	1.9	1.9	NUM
gs-3688	100	12	intermediate	intermediate	ADJ
gs-3688	100	13	precision	precision	NOUN
gs-3688	100	14	(	(	PUNCT
gs-3688	100	15	intra	intra	ADJ
gs-3688	100	16	-	-	ADJ
gs-3688	100	17	day	day	NOUN
gs-3688	100	18	)	)	PUNCT
gs-3688	100	19	%	%	NOUN
gs-3688	100	20	rsd	rsd	PROPN
gs-3688	100	21	(	(	PUNCT
gs-3688	100	22	n=18	n=18	PROPN
gs-3688	100	23	)	)	PUNCT
gs-3688	100	24	3.3	3.3	NUM
gs-3688	100	25	4	4	NUM
gs-3688	100	26	.	.	PUNCT
gs-3688	101	1	conclusions	conclusion	NOUN
gs-3688	101	2	a	a	DET
gs-3688	101	3	novel	novel	ADJ
gs-3688	101	4	technique	technique	NOUN
gs-3688	101	5	for	for	ADP
gs-3688	101	6	measuring	measure	VERB
gs-3688	101	7	the	the	DET
gs-3688	101	8	pharmacologically	pharmacologically	ADV
gs-3688	101	9	active	active	ADJ
gs-3688	101	10	alkaloid	alkaloid	ADJ
gs-3688	101	11	berberine	berberine	NOUN
gs-3688	101	12	in	in	ADP
gs-3688	101	13	the	the	DET
gs-3688	101	14	biologically	biologically	ADV
gs-3688	101	15	active	active	ADJ
gs-3688	101	16	extract	extract	NOUN
gs-3688	101	17	from	from	ADP
gs-3688	101	18	the	the	DET
gs-3688	101	19	areal	areal	NOUN
gs-3688	101	20	part	part	NOUN
gs-3688	101	21	of	of	ADP
gs-3688	101	22	m.	m.	PROPN
gs-3688	101	23	aquifolium	aquifolium	PROPN
gs-3688	101	24	was	be	AUX
gs-3688	101	25	developed	develop	VERB
gs-3688	101	26	.	.	PUNCT
gs-3688	102	1	in	in	ADP
gs-3688	102	2	conclusion	conclusion	NOUN
gs-3688	102	3	,	,	PUNCT
gs-3688	102	4	the	the	DET
gs-3688	102	5	established	establish	VERB
gs-3688	102	6	method	method	NOUN
gs-3688	102	7	for	for	ADP
gs-3688	102	8	the	the	DET
gs-3688	102	9	quantitation	quantitation	NOUN
gs-3688	102	10	of	of	ADP
gs-3688	102	11	berberine	berberine	NOUN
gs-3688	102	12	demonstrates	demonstrate	VERB
gs-3688	102	13	significant	significant	ADJ
gs-3688	102	14	novelty	novelty	NOUN
gs-3688	102	15	and	and	CCONJ
gs-3688	102	16	innovation	innovation	NOUN
gs-3688	102	17	for	for	ADP
gs-3688	102	18	the	the	DET
gs-3688	102	19	quantification	quantification	NOUN
gs-3688	102	20	of	of	ADP
gs-3688	102	21	the	the	DET
gs-3688	102	22	biologically	biologically	ADV
gs-3688	102	23	active	active	ADJ
gs-3688	102	24	extract	extract	NOUN
gs-3688	102	25	from	from	ADP
gs-3688	102	26	the	the	DET
gs-3688	102	27	areal	areal	NOUN
gs-3688	102	28	part	part	NOUN
gs-3688	102	29	of	of	ADP
gs-3688	102	30	m.	m.	NOUN
gs-3688	102	31	aquifolium	aquifolium	PROPN
gs-3688	102	32	.	.	PUNCT
gs-3688	103	1	the	the	DET
gs-3688	103	2	methodological	methodological	ADJ
gs-3688	103	3	advances	advance	NOUN
gs-3688	103	4	in	in	ADP
gs-3688	103	5	hplc	hplc	NOUN
gs-3688	103	6	analysis	analysis	NOUN
gs-3688	103	7	enhance	enhance	NOUN
gs-3688	103	8	accuracy	accuracy	NOUN
gs-3688	103	9	,	,	PUNCT
gs-3688	103	10	sensitivity	sensitivity	NOUN
gs-3688	103	11	,	,	PUNCT
gs-3688	103	12	and	and	CCONJ
gs-3688	103	13	reproducibility	reproducibility	NOUN
gs-3688	103	14	.	.	PUNCT
gs-3688	104	1	the	the	DET
gs-3688	104	2	innovation	innovation	NOUN
gs-3688	104	3	in	in	ADP
gs-3688	104	4	analytical	analytical	ADJ
gs-3688	104	5	parameters	parameter	NOUN
gs-3688	104	6	reduces	reduce	VERB
gs-3688	104	7	both	both	CCONJ
gs-3688	104	8	the	the	DET
gs-3688	104	9	detection	detection	NOUN
gs-3688	104	10	limit	limit	NOUN
gs-3688	104	11	and	and	CCONJ
gs-3688	104	12	the	the	DET
gs-3688	104	13	quantitative	quantitative	ADJ
gs-3688	104	14	determination	determination	NOUN
gs-3688	104	15	limit	limit	NOUN
gs-3688	104	16	of	of	ADP
gs-3688	104	17	berberine	berberine	NOUN
gs-3688	104	18	.	.	PUNCT
gs-3688	105	1	validation	validation	NOUN
gs-3688	105	2	confirms	confirm	VERB
gs-3688	105	3	the	the	DET
gs-3688	105	4	method	method	NOUN
gs-3688	105	5	's	's	PART
gs-3688	105	6	reliability	reliability	NOUN
gs-3688	105	7	and	and	CCONJ
gs-3688	105	8	reproducibility	reproducibility	NOUN
gs-3688	105	9	,	,	PUNCT
gs-3688	105	10	underscoring	underscore	VERB
gs-3688	105	11	its	its	PRON
gs-3688	105	12	practical	practical	ADJ
gs-3688	105	13	value	value	NOUN
gs-3688	105	14	.	.	PUNCT
gs-3688	106	1	disclosure	disclosure	NOUN
gs-3688	106	2	statement	statement	NOUN
gs-3688	106	3	the	the	DET
gs-3688	106	4	authors	author	NOUN
gs-3688	106	5	report	report	VERB
gs-3688	106	6	there	there	PRON
gs-3688	106	7	are	be	VERB
gs-3688	106	8	no	no	DET
gs-3688	106	9	competing	compete	VERB
gs-3688	106	10	interests	interest	NOUN
gs-3688	106	11	to	to	PART
gs-3688	106	12	declare	declare	VERB
gs-3688	106	13	.	.	PUNCT
gs-3688	107	1	georgian	georgian	ADJ
gs-3688	107	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3688	107	3	მეცნიერები	მეცნიერები	NOUN
gs-3688	107	4	ტ.	ტ.	VERB
gs-3688	107	5	7	7	NUM
gs-3688	107	6	n	n	DET
gs-3688	107	7	2	2	NUM
gs-3688	107	8	,	,	PUNCT
gs-3688	107	9	2025	2025	NUM
gs-3688	107	10	303	303	NUM
gs-3688	107	11	references	reference	NOUN
gs-3688	107	12	(	(	PUNCT
gs-3688	107	13	1	1	NUM
gs-3688	107	14	)	)	PUNCT
gs-3688	107	15	ferreira	ferreira	PROPN
gs-3688	107	16	,	,	PUNCT
gs-3688	107	17	m.-j	m.-j	PROPN
gs-3688	107	18	.	.	PUNCT
gs-3688	108	1	u.	u.	PROPN
gs-3688	108	2	alkaloids	alkaloid	NOUN
gs-3688	108	3	in	in	ADP
gs-3688	108	4	future	future	ADJ
gs-3688	108	5	drug	drug	NOUN
gs-3688	108	6	discovery	discovery	NOUN
gs-3688	108	7	.	.	PUNCT
gs-3688	109	1	molecules	molecule	NOUN
gs-3688	109	2	2022	2022	NUM
gs-3688	109	3	,	,	PUNCT
gs-3688	109	4	27	27	NUM
gs-3688	109	5	(	(	PUNCT
gs-3688	109	6	4	4	NUM
gs-3688	109	7	)	)	PUNCT
gs-3688	109	8	,	,	PUNCT
gs-3688	109	9	1347	1347	NUM
gs-3688	109	10	.	.	PUNCT
gs-3688	110	1	https://doi.org/10.3390/molecules27041347	https://doi.org/10.3390/molecules27041347	ADJ
gs-3688	110	2	.	.	PUNCT
gs-3688	111	1	(	(	PUNCT
gs-3688	111	2	2	2	X
gs-3688	111	3	)	)	PUNCT
gs-3688	111	4	martin	martin	PROPN
gs-3688	111	5	,	,	PUNCT
gs-3688	111	6	s.	s.	PROPN
gs-3688	111	7	f.	f.	PROPN
gs-3688	111	8	bridging	bridging	PROPN
gs-3688	111	9	known	know	VERB
gs-3688	111	10	and	and	CCONJ
gs-3688	111	11	unknown	unknown	ADJ
gs-3688	111	12	unknowns	unknown	NOUN
gs-3688	111	13	:	:	PUNCT
gs-3688	111	14	from	from	ADP
gs-3688	111	15	natural	natural	ADJ
gs-3688	111	16	products	product	NOUN
gs-3688	111	17	and	and	CCONJ
gs-3688	111	18	their	their	PRON
gs-3688	111	19	mimics	mimic	NOUN
gs-3688	111	20	to	to	ADP
gs-3688	111	21	unmet	unmet	NOUN
gs-3688	111	22	needs	need	NOUN
gs-3688	111	23	in	in	ADP
gs-3688	111	24	neuroscience	neuroscience	NOUN
gs-3688	111	25	.	.	PUNCT
gs-3688	112	1	accounts	account	NOUN
gs-3688	112	2	of	of	ADP
gs-3688	112	3	chemical	chemical	ADJ
gs-3688	112	4	research	research	NOUN
gs-3688	112	5	2022	2022	NUM
gs-3688	112	6	,	,	PUNCT
gs-3688	112	7	55	55	NUM
gs-3688	112	8	(	(	PUNCT
gs-3688	112	9	17	17	NUM
gs-3688	112	10	)	)	PUNCT
gs-3688	112	11	,	,	PUNCT
gs-3688	112	12	2397–2408	2397–2408	NUM
gs-3688	112	13	.	.	PUNCT
gs-3688	112	14	https://doi.org/10.1021/acs.accounts.1c00773	https://doi.org/10.1021/acs.accounts.1c00773	NOUN
gs-3688	112	15	.	.	PUNCT
gs-3688	113	1	(	(	PUNCT
gs-3688	113	2	3	3	X
gs-3688	113	3	)	)	PUNCT
gs-3688	113	4	wang	wang	PROPN
gs-3688	113	5	,	,	PUNCT
gs-3688	113	6	h.	h.	PROPN
gs-3688	113	7	;	;	PUNCT
gs-3688	113	8	xu	xu	PROPN
gs-3688	113	9	,	,	PUNCT
gs-3688	113	10	x.	x.	PROPN
gs-3688	113	11	;	;	PUNCT
gs-3688	113	12	wang	wang	PROPN
gs-3688	113	13	,	,	PUNCT
gs-3688	113	14	x.	x.	PROPN
gs-3688	113	15	;	;	PUNCT
gs-3688	113	16	guo	guo	PROPN
gs-3688	113	17	,	,	PUNCT
gs-3688	113	18	w.	w.	PROPN
gs-3688	113	19	;	;	PUNCT
gs-3688	113	20	jia	jia	PROPN
gs-3688	113	21	,	,	PUNCT
gs-3688	113	22	w.	w.	PROPN
gs-3688	113	23	;	;	PUNCT
gs-3688	113	24	zhang	zhang	PROPN
gs-3688	113	25	,	,	PUNCT
gs-3688	113	26	f.	f.	PROPN
gs-3688	113	27	an	an	DET
gs-3688	113	28	analytical	analytical	ADJ
gs-3688	113	29	strategy	strategy	NOUN
gs-3688	113	30	for	for	ADP
gs-3688	113	31	discovering	discover	VERB
gs-3688	113	32	structural	structural	ADJ
gs-3688	113	33	analogues	analogue	NOUN
gs-3688	113	34	of	of	ADP
gs-3688	113	35	alkaloids	alkaloid	NOUN
gs-3688	113	36	in	in	ADP
gs-3688	113	37	plant	plant	NOUN
gs-3688	113	38	food	food	NOUN
gs-3688	113	39	using	use	VERB
gs-3688	113	40	characteristic	characteristic	ADJ
gs-3688	113	41	structural	structural	ADJ
gs-3688	113	42	fragments	fragment	NOUN
gs-3688	113	43	extraction	extraction	NOUN
gs-3688	113	44	by	by	ADP
gs-3688	113	45	high	high	ADJ
gs-3688	113	46	resolution	resolution	NOUN
gs-3688	113	47	orbitrap	orbitrap	NOUN
gs-3688	113	48	mass	mass	PROPN
gs-3688	113	49	spectrometry	spectrometry	NOUN
gs-3688	113	50	.	.	PUNCT
gs-3688	114	1	lwt	lwt	PROPN
gs-3688	114	2	2022	2022	NUM
gs-3688	114	3	,	,	PUNCT
gs-3688	114	4	154	154	NUM
gs-3688	114	5	,	,	PUNCT
gs-3688	114	6	112329	112329	NUM
gs-3688	114	7	.	.	PUNCT
gs-3688	115	1	https://doi.org/10.1016/j.lwt.2021.112329	https://doi.org/10.1016/j.lwt.2021.112329	X
gs-3688	115	2	.	.	PUNCT
gs-3688	116	1	(	(	PUNCT
gs-3688	116	2	4	4	X
gs-3688	116	3	)	)	PUNCT
gs-3688	116	4	singh	singh	NOUN
gs-3688	116	5	,	,	PUNCT
gs-3688	116	6	p.	p.	NOUN
gs-3688	116	7	a.	a.	NOUN
gs-3688	116	8	;	;	PUNCT
gs-3688	116	9	bajwa	bajwa	PROPN
gs-3688	116	10	,	,	PUNCT
gs-3688	116	11	n.	n.	NOUN
gs-3688	116	12	;	;	PUNCT
gs-3688	116	13	chinnam	chinnam	PROPN
gs-3688	116	14	,	,	PUNCT
gs-3688	116	15	s.	s.	PROPN
gs-3688	116	16	;	;	PUNCT
gs-3688	116	17	chandan	chandan	PROPN
gs-3688	116	18	,	,	PUNCT
gs-3688	116	19	a.	a.	PROPN
gs-3688	116	20	;	;	PUNCT
gs-3688	116	21	baldi	baldi	PROPN
gs-3688	116	22	,	,	PUNCT
gs-3688	116	23	a.	a.	NOUN
gs-3688	116	24	an	an	DET
gs-3688	116	25	overview	overview	NOUN
gs-3688	116	26	of	of	ADP
gs-3688	116	27	some	some	DET
gs-3688	116	28	important	important	ADJ
gs-3688	116	29	deliberations	deliberation	NOUN
gs-3688	116	30	to	to	PART
gs-3688	116	31	promote	promote	VERB
gs-3688	116	32	medicinal	medicinal	ADJ
gs-3688	116	33	plants	plant	NOUN
gs-3688	116	34	cultivation	cultivation	NOUN
gs-3688	116	35	.	.	PUNCT
gs-3688	117	1	journal	journal	NOUN
gs-3688	117	2	of	of	ADP
gs-3688	117	3	applied	apply	VERB
gs-3688	117	4	research	research	NOUN
gs-3688	117	5	on	on	ADP
gs-3688	117	6	medicinal	medicinal	ADJ
gs-3688	117	7	and	and	CCONJ
gs-3688	117	8	aromatic	aromatic	ADJ
gs-3688	117	9	plants	plant	NOUN
gs-3688	117	10	2022	2022	NUM
gs-3688	117	11	,	,	PUNCT
gs-3688	117	12	100400	100400	NUM
gs-3688	117	13	.	.	PUNCT
gs-3688	118	1	https://doi.org/10.1016/j.jarmap.2022.100400	https://doi.org/10.1016/j.jarmap.2022.100400	NOUN
gs-3688	118	2	.	.	PUNCT
gs-3688	119	1	(	(	PUNCT
gs-3688	119	2	5	5	X
gs-3688	119	3	)	)	PUNCT
gs-3688	119	4	bhambhani	bhambhani	ADJ
gs-3688	119	5	,	,	PUNCT
gs-3688	119	6	s.	s.	PROPN
gs-3688	119	7	;	;	PUNCT
gs-3688	119	8	kondhare	kondhare	PROPN
gs-3688	119	9	,	,	PUNCT
gs-3688	119	10	k.	k.	PROPN
gs-3688	119	11	r.	r.	PROPN
gs-3688	119	12	;	;	PUNCT
gs-3688	120	1	giri	giri	PROPN
gs-3688	120	2	,	,	PUNCT
gs-3688	120	3	a.	a.	NOUN
gs-3688	120	4	p.	p.	NOUN
gs-3688	120	5	diversity	diversity	NOUN
gs-3688	120	6	in	in	ADP
gs-3688	120	7	chemical	chemical	NOUN
gs-3688	120	8	structures	structure	NOUN
gs-3688	120	9	and	and	CCONJ
gs-3688	120	10	biological	biological	ADJ
gs-3688	120	11	properties	property	NOUN
gs-3688	120	12	of	of	ADP
gs-3688	120	13	plant	plant	NOUN
gs-3688	120	14	alkaloids	alkaloid	NOUN
gs-3688	120	15	.	.	PUNCT
gs-3688	120	16	molecules	molecule	NOUN
gs-3688	120	17	2021	2021	NUM
gs-3688	120	18	,	,	PUNCT
gs-3688	120	19	26	26	NUM
gs-3688	120	20	(	(	PUNCT
gs-3688	120	21	11	11	NUM
gs-3688	120	22	)	)	PUNCT
gs-3688	120	23	,	,	PUNCT
gs-3688	120	24	3374	3374	NUM
gs-3688	120	25	.	.	PUNCT
gs-3688	121	1	https://doi.org/10.3390/molecules26113374	https://doi.org/10.3390/molecules26113374	PROPN
gs-3688	121	2	.	.	PUNCT
gs-3688	122	1	(	(	PUNCT
gs-3688	122	2	6	6	X
gs-3688	122	3	)	)	PUNCT
gs-3688	122	4	rajput	rajput	PROPN
gs-3688	122	5	,	,	PUNCT
gs-3688	122	6	a.	a.	NOUN
gs-3688	122	7	;	;	PUNCT
gs-3688	122	8	sharma	sharma	PROPN
gs-3688	122	9	,	,	PUNCT
gs-3688	122	10	r.	r.	PROPN
gs-3688	122	11	;	;	PUNCT
gs-3688	122	12	bharti	bharti	PROPN
gs-3688	122	13	,	,	PUNCT
gs-3688	122	14	r.	r.	PROPN
gs-3688	122	15	pharmacological	pharmacological	NOUN
gs-3688	122	16	activities	activity	NOUN
gs-3688	122	17	and	and	CCONJ
gs-3688	122	18	toxicities	toxicity	NOUN
gs-3688	122	19	of	of	ADP
gs-3688	122	20	alkaloids	alkaloid	NOUN
gs-3688	122	21	on	on	ADP
gs-3688	122	22	human	human	ADJ
gs-3688	122	23	health	health	NOUN
gs-3688	122	24	.	.	PUNCT
gs-3688	123	1	materials	material	NOUN
gs-3688	123	2	today	today	NOUN
gs-3688	123	3	:	:	PUNCT
gs-3688	123	4	proceedings	proceeding	NOUN
gs-3688	123	5	2022	2022	NUM
gs-3688	123	6	,	,	PUNCT
gs-3688	123	7	48	48	NUM
gs-3688	123	8	,	,	PUNCT
gs-3688	123	9	1407–1415	1407–1415	NUM
gs-3688	123	10	.	.	PUNCT
gs-3688	124	1	https://doi.org/10.1016/j.matpr.2021.09.189	https://doi.org/10.1016/j.matpr.2021.09.189	PROPN
gs-3688	124	2	.	.	PUNCT
gs-3688	125	1	(	(	PUNCT
gs-3688	125	2	7	7	X
gs-3688	125	3	)	)	PUNCT
gs-3688	125	4	matsuura	matsuura	PROPN
gs-3688	125	5	,	,	PUNCT
gs-3688	125	6	h.	h.	PROPN
gs-3688	125	7	n.	n.	PROPN
gs-3688	125	8	;	;	PUNCT
gs-3688	125	9	fett	fett	PROPN
gs-3688	125	10	-	-	PUNCT
gs-3688	125	11	neto	neto	NOUN
gs-3688	125	12	,	,	PUNCT
gs-3688	125	13	a.	a.	NOUN
gs-3688	125	14	g.	g.	PROPN
gs-3688	125	15	plant	plant	NOUN
gs-3688	125	16	alkaloids	alkaloid	NOUN
gs-3688	125	17	:	:	PUNCT
gs-3688	125	18	main	main	ADJ
gs-3688	125	19	features	feature	NOUN
gs-3688	125	20	,	,	PUNCT
gs-3688	125	21	toxicity	toxicity	NOUN
gs-3688	125	22	,	,	PUNCT
gs-3688	125	23	and	and	CCONJ
gs-3688	125	24	mechanisms	mechanism	NOUN
gs-3688	125	25	of	of	ADP
gs-3688	125	26	action	action	NOUN
gs-3688	125	27	.	.	PUNCT
gs-3688	126	1	plant	plant	NOUN
gs-3688	126	2	toxins	toxin	NOUN
gs-3688	126	3	2015	2015	NUM
gs-3688	126	4	,	,	PUNCT
gs-3688	126	5	1–15	1–15	NUM
gs-3688	126	6	.	.	PUNCT
gs-3688	127	1	https://doi.org/10.1007/978-94-007-6728-7_2-1	https://doi.org/10.1007/978-94-007-6728-7_2-1	PROPN
gs-3688	127	2	.	.	PUNCT
gs-3688	128	1	(	(	PUNCT
gs-3688	128	2	8)	8)	NUM
gs-3688	128	3	heinrich	heinrich	NOUN
gs-3688	128	4	,	,	PUNCT
gs-3688	128	5	m.	m.	NOUN
gs-3688	128	6	;	;	PUNCT
gs-3688	128	7	mah	mah	PROPN
gs-3688	128	8	,	,	PUNCT
gs-3688	128	9	j.	j.	PROPN
gs-3688	128	10	;	;	PUNCT
gs-3688	128	11	amirkia	amirkia	NOUN
gs-3688	128	12	,	,	PUNCT
gs-3688	128	13	v.	v.	ADP
gs-3688	128	14	alkaloids	alkaloid	NOUN
gs-3688	128	15	used	use	VERB
gs-3688	128	16	as	as	ADP
gs-3688	128	17	medicines	medicine	NOUN
gs-3688	128	18	:	:	PUNCT
gs-3688	128	19	structural	structural	ADJ
gs-3688	128	20	phytochemistry	phytochemistry	NOUN
gs-3688	128	21	meets	meet	VERB
gs-3688	128	22	biodiversity	biodiversity	NOUN
gs-3688	128	23	—	—	PUNCT
gs-3688	128	24	an	an	DET
gs-3688	128	25	update	update	NOUN
gs-3688	128	26	and	and	CCONJ
gs-3688	128	27	forward	forward	ADV
gs-3688	128	28	look	look	VERB
gs-3688	128	29	.	.	PUNCT
gs-3688	129	1	molecules	molecule	NOUN
gs-3688	129	2	2021	2021	NUM
gs-3688	129	3	,	,	PUNCT
gs-3688	129	4	26	26	NUM
gs-3688	129	5	(	(	PUNCT
gs-3688	129	6	7	7	NUM
gs-3688	129	7	)	)	PUNCT
gs-3688	129	8	,	,	PUNCT
gs-3688	129	9	1836	1836	NUM
gs-3688	129	10	.	.	PUNCT
gs-3688	130	1	https://doi.org/10.3390/molecules26071836	https://doi.org/10.3390/molecules26071836	NOUN
gs-3688	130	2	.	.	PUNCT
gs-3688	131	1	(	(	PUNCT
gs-3688	131	2	9	9	X
gs-3688	131	3	)	)	PUNCT
gs-3688	131	4	och	och	PROPN
gs-3688	131	5	,	,	PUNCT
gs-3688	131	6	a.	a.	NOUN
gs-3688	131	7	;	;	PUNCT
gs-3688	131	8	podgórski	podgórski	PROPN
gs-3688	131	9	,	,	PUNCT
gs-3688	131	10	r.	r.	PROPN
gs-3688	131	11	;	;	PUNCT
gs-3688	131	12	nowak	nowak	PROPN
gs-3688	131	13	,	,	PUNCT
gs-3688	131	14	r.	r.	PROPN
gs-3688	131	15	biological	biological	ADJ
gs-3688	131	16	activity	activity	NOUN
gs-3688	131	17	of	of	ADP
gs-3688	131	18	berberine	berberine	NOUN
gs-3688	131	19	—	—	PUNCT
gs-3688	131	20	a	a	DET
gs-3688	131	21	summary	summary	NOUN
gs-3688	131	22	update	update	NOUN
gs-3688	131	23	.	.	PUNCT
gs-3688	132	1	toxins	toxin	NOUN
gs-3688	132	2	2020	2020	NUM
gs-3688	132	3	,	,	PUNCT
gs-3688	132	4	12	12	NUM
gs-3688	132	5	(	(	PUNCT
gs-3688	132	6	11	11	NUM
gs-3688	132	7	)	)	PUNCT
gs-3688	132	8	,	,	PUNCT
gs-3688	132	9	713	713	NUM
gs-3688	132	10	.	.	PUNCT
gs-3688	133	1	https://doi.org/10.3390/toxins12110713	https://doi.org/10.3390/toxins12110713	PROPN
gs-3688	133	2	.	.	PUNCT
gs-3688	134	1	(	(	PUNCT
gs-3688	134	2	10	10	NUM
gs-3688	134	3	)	)	PUNCT
gs-3688	134	4	garcía	garcía	NOUN
gs-3688	134	5	-	-	PUNCT
gs-3688	134	6	muñoz	muñoz	PROPN
gs-3688	134	7	,	,	PUNCT
gs-3688	134	8	a.	a.	NOUN
gs-3688	134	9	m.	m.	NOUN
gs-3688	134	10	;	;	PUNCT
gs-3688	134	11	desirée	desirée	PROPN
gs-3688	134	12	victoria	victoria	PROPN
gs-3688	134	13	-	-	PUNCT
gs-3688	134	14	montesinos	montesino	NOUN
gs-3688	134	15	;	;	PUNCT
gs-3688	134	16	ballester	ballester	NOUN
gs-3688	134	17	,	,	PUNCT
gs-3688	134	18	p.	p.	NOUN
gs-3688	134	19	;	;	PUNCT
gs-3688	134	20	begoña	begoña	ADV
gs-3688	134	21	cerdá	cerdá	NOUN
gs-3688	134	22	;	;	PUNCT
gs-3688	134	23	zafrilla	zafrilla	NOUN
gs-3688	134	24	,	,	PUNCT
gs-3688	134	25	p.	p.	NOUN
gs-3688	134	26	a	a	DET
gs-3688	134	27	descriptive	descriptive	ADJ
gs-3688	134	28	review	review	NOUN
gs-3688	134	29	of	of	ADP
gs-3688	134	30	the	the	DET
gs-3688	134	31	antioxidant	antioxidant	ADJ
gs-3688	134	32	effects	effect	NOUN
gs-3688	134	33	and	and	CCONJ
gs-3688	134	34	mechanisms	mechanism	NOUN
gs-3688	134	35	of	of	ADP
gs-3688	134	36	action	action	NOUN
gs-3688	134	37	of	of	ADP
gs-3688	134	38	berberine	berberine	NOUN
gs-3688	134	39	and	and	CCONJ
gs-3688	134	40	silymarin	silymarin	NOUN
gs-3688	134	41	.	.	PUNCT
gs-3688	135	1	molecules	molecule	NOUN
gs-3688	135	2	2024	2024	NUM
gs-3688	135	3	,	,	PUNCT
gs-3688	135	4	29	29	NUM
gs-3688	135	5	(	(	PUNCT
gs-3688	135	6	19	19	NUM
gs-3688	135	7	)	)	PUNCT
gs-3688	135	8	,	,	PUNCT
gs-3688	135	9	4576–4576	4576–4576	NUM
gs-3688	135	10	.	.	PUNCT
gs-3688	136	1	https://doi.org/10.3390/molecules29194576	https://doi.org/10.3390/molecules29194576	PROPN
gs-3688	136	2	.	.	PUNCT
gs-3688	137	1	(	(	PUNCT
gs-3688	137	2	11	11	NUM
gs-3688	137	3	)	)	PUNCT
gs-3688	137	4	naz	naz	PROPN
gs-3688	137	5	,	,	PUNCT
gs-3688	137	6	i.	i.	PROPN
gs-3688	137	7	;	;	PUNCT
gs-3688	137	8	masoud	masoud	PROPN
gs-3688	137	9	,	,	PUNCT
gs-3688	137	10	m.	m.	NOUN
gs-3688	137	11	s.	s.	PROPN
gs-3688	137	12	;	;	PUNCT
gs-3688	137	13	chauhdary	chauhdary	ADJ
gs-3688	137	14	,	,	PUNCT
gs-3688	137	15	z.	z.	PROPN
gs-3688	137	16	;	;	PUNCT
gs-3688	137	17	shah	shah	NOUN
gs-3688	137	18	,	,	PUNCT
gs-3688	137	19	m.	m.	NOUN
gs-3688	137	20	a.	a.	PROPN
gs-3688	137	21	;	;	PUNCT
gs-3688	137	22	panichayupakaranant	panichayupakaranant	NOUN
gs-3688	137	23	,	,	PUNCT
gs-3688	137	24	p.	p.	NOUN
gs-3688	137	25	anti	anti	ADJ
gs-3688	137	26	-	-	ADJ
gs-3688	137	27	inflammatory	inflammatory	ADJ
gs-3688	137	28	potential	potential	NOUN
gs-3688	137	29	of	of	ADP
gs-3688	137	30	berberine	berberine	NOUN
gs-3688	137	31	-	-	PUNCT
gs-3688	137	32	rich	rich	ADJ
gs-3688	137	33	extract	extract	NOUN
gs-3688	137	34	via	via	ADP
gs-3688	137	35	modulation	modulation	NOUN
gs-3688	137	36	of	of	ADP
gs-3688	137	37	inflammation	inflammation	ADJ
gs-3688	137	38	biomarkers	biomarker	NOUN
gs-3688	137	39	.	.	PUNCT
gs-3688	138	1	journal	journal	NOUN
gs-3688	138	2	of	of	ADP
gs-3688	138	3	food	food	NOUN
gs-3688	138	4	biochemistry	biochemistry	NOUN
gs-3688	138	5	2022	2022	NUM
gs-3688	138	6	,	,	PUNCT
gs-3688	138	7	46	46	NUM
gs-3688	138	8	(	(	PUNCT
gs-3688	138	9	12	12	NUM
gs-3688	138	10	)	)	PUNCT
gs-3688	138	11	,	,	PUNCT
gs-3688	138	12	e14389	e14389	PROPN
gs-3688	138	13	.	.	PUNCT
gs-3688	138	14	https://doi.org/10.1111/jfbc.14389	https://doi.org/10.1111/jfbc.14389	PROPN
gs-3688	138	15	.	.	PUNCT
gs-3688	139	1	(	(	PUNCT
gs-3688	139	2	12	12	NUM
gs-3688	139	3	)	)	PUNCT
gs-3688	139	4	cheng	cheng	PROPN
gs-3688	139	5	,	,	PUNCT
gs-3688	139	6	z.	z.	PROPN
gs-3688	139	7	;	;	PUNCT
gs-3688	139	8	kang	kang	PROPN
gs-3688	139	9	,	,	PUNCT
gs-3688	139	10	c.	c.	PROPN
gs-3688	139	11	;	;	PUNCT
gs-3688	139	12	che	che	PROPN
gs-3688	139	13	,	,	PUNCT
gs-3688	139	14	s.	s.	PROPN
gs-3688	139	15	;	;	PUNCT
gs-3688	139	16	su	su	PROPN
gs-3688	139	17	,	,	PUNCT
gs-3688	139	18	j.	j.	PROPN
gs-3688	139	19	;	;	PUNCT
gs-3688	139	20	sun	sun	PROPN
gs-3688	139	21	,	,	PUNCT
gs-3688	139	22	q.	q.	PROPN
gs-3688	139	23	;	;	PUNCT
gs-3688	139	24	ge	ge	PROPN
gs-3688	139	25	,	,	PUNCT
gs-3688	139	26	t.	t.	PROPN
gs-3688	139	27	;	;	PUNCT
gs-3688	139	28	guo	guo	PROPN
gs-3688	139	29	,	,	PUNCT
gs-3688	139	30	y.	y.	PROPN
gs-3688	139	31	;	;	PUNCT
gs-3688	139	32	lv	lv	PROPN
gs-3688	139	33	,	,	PUNCT
gs-3688	139	34	j.	j.	PROPN
gs-3688	139	35	;	;	PUNCT
gs-3688	139	36	sun	sun	PROPN
gs-3688	139	37	,	,	PUNCT
gs-3688	139	38	z.	z.	PROPN
gs-3688	139	39	;	;	PUNCT
gs-3688	139	40	yang	yang	PROPN
gs-3688	139	41	,	,	PUNCT
gs-3688	139	42	w.	w.	PROPN
gs-3688	139	43	;	;	PUNCT
gs-3688	139	44	li	li	PROPN
gs-3688	139	45	,	,	PUNCT
gs-3688	139	46	b.	b.	PROPN
gs-3688	139	47	;	;	PUNCT
gs-3688	139	48	li	li	PROPN
gs-3688	139	49	,	,	PUNCT
gs-3688	139	50	x.	x.	NOUN
gs-3688	139	51	;	;	PUNCT
gs-3688	139	52	cui	cui	PROPN
gs-3688	139	53	,	,	PUNCT
gs-3688	139	54	r.	r.	PROPN
gs-3688	139	55	berberine	berberine	PROPN
gs-3688	139	56	:	:	PUNCT
gs-3688	139	57	a	a	DET
gs-3688	139	58	promising	promising	ADJ
gs-3688	139	59	treatment	treatment	NOUN
gs-3688	139	60	for	for	ADP
gs-3688	139	61	neurodegenerative	neurodegenerative	ADJ
gs-3688	139	62	diseases	disease	NOUN
gs-3688	139	63	.	.	PUNCT
gs-3688	140	1	frontiers	frontier	NOUN
gs-3688	140	2	in	in	ADP
gs-3688	140	3	pharmacology	pharmacology	NOUN
gs-3688	140	4	2022	2022	NUM
gs-3688	140	5	,	,	PUNCT
gs-3688	140	6	13	13	NUM
gs-3688	140	7	.	.	PUNCT
gs-3688	141	1	https://doi.org/10.3389/fphar.2022.845591	https://doi.org/10.3389/fphar.2022.845591	PROPN
gs-3688	141	2	.	.	PUNCT
gs-3688	142	1	(	(	PUNCT
gs-3688	142	2	13	13	NUM
gs-3688	142	3	)	)	PUNCT
gs-3688	142	4	kang	kang	PROPN
gs-3688	142	5	,	,	PUNCT
gs-3688	142	6	h.-g	h.-g	PROPN
gs-3688	142	7	.	.	PUNCT
gs-3688	142	8	;	;	PUNCT
gs-3688	143	1	wei	wei	PROPN
gs-3688	143	2	,	,	PUNCT
gs-3688	143	3	m.-l	m.-l	PROPN
gs-3688	143	4	.	.	PUNCT
gs-3688	143	5	;	;	PUNCT
gs-3688	143	6	wang	wang	PROPN
gs-3688	143	7	,	,	PUNCT
gs-3688	143	8	j.-l	j.-l	PROPN
gs-3688	143	9	.	.	PUNCT
gs-3688	143	10	;	;	PUNCT
gs-3688	143	11	ma	ma	PROPN
gs-3688	143	12	,	,	PUNCT
gs-3688	143	13	c.-p	c.-p	PROPN
gs-3688	143	14	.	.	PROPN
gs-3688	143	15	;	;	PUNCT
gs-3688	143	16	zhang	zhang	PROPN
gs-3688	143	17	,	,	PUNCT
gs-3688	143	18	x.	x.	PROPN
gs-3688	143	19	;	;	PUNCT
gs-3688	143	20	huang	huang	PROPN
gs-3688	143	21	,	,	PUNCT
gs-3688	143	22	b.-w	b.-w	PROPN
gs-3688	143	23	.	.	PUNCT
gs-3688	143	24	;	;	PUNCT
gs-3688	143	25	xin	xin	PROPN
gs-3688	143	26	,	,	PUNCT
gs-3688	143	27	l.-s	l.-s	PROPN
gs-3688	143	28	.	.	PUNCT
gs-3688	143	29	;	;	PUNCT
gs-3688	143	30	bai	bai	PROPN
gs-3688	143	31	,	,	PUNCT
gs-3688	143	32	c.-m	c.-m	NOUN
gs-3688	143	33	.	.	PUNCT
gs-3688	144	1	georgian	georgian	ADJ
gs-3688	144	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3688	144	3	მეცნიერები	მეცნიერები	NOUN
gs-3688	144	4	ტ.	ტ.	VERB
gs-3688	144	5	7	7	NUM
gs-3688	144	6	n	n	DET
gs-3688	144	7	2	2	NUM
gs-3688	144	8	,	,	PUNCT
gs-3688	144	9	2025	2025	NUM
gs-3688	144	10	304	304	NUM
gs-3688	144	11	berberine	berberine	NOUN
gs-3688	144	12	,	,	PUNCT
gs-3688	144	13	a	a	DET
gs-3688	144	14	natural	natural	ADJ
gs-3688	144	15	compound	compound	NOUN
gs-3688	144	16	that	that	PRON
gs-3688	144	17	demonstrates	demonstrate	VERB
gs-3688	144	18	antiviral	antiviral	ADJ
gs-3688	144	19	effects	effect	NOUN
gs-3688	144	20	against	against	ADP
gs-3688	144	21	ostreid	ostreid	ADJ
gs-3688	144	22	herpesvirus	herpesvirus	NOUN
gs-3688	144	23	1	1	NUM
gs-3688	144	24	infection	infection	NOUN
gs-3688	144	25	in	in	ADP
gs-3688	144	26	anadara	anadara	NOUN
gs-3688	144	27	broughtonii	broughtonii	NOUN
gs-3688	144	28	.	.	PUNCT
gs-3688	145	1	viruses	virus	NOUN
gs-3688	145	2	2025	2025	NUM
gs-3688	145	3	,	,	PUNCT
gs-3688	145	4	17	17	NUM
gs-3688	145	5	(	(	PUNCT
gs-3688	145	6	2	2	NUM
gs-3688	145	7	)	)	PUNCT
gs-3688	145	8	,	,	PUNCT
gs-3688	145	9	282	282	NUM
gs-3688	145	10	.	.	PUNCT
gs-3688	146	1	https://doi.org/10.3390/v17020282	https://doi.org/10.3390/v17020282	NUM
gs-3688	146	2	.	.	PUNCT
gs-3688	147	1	(	(	PUNCT
gs-3688	147	2	14	14	NUM
gs-3688	147	3	)	)	PUNCT
gs-3688	147	4	sun	sun	NOUN
gs-3688	147	5	,	,	PUNCT
gs-3688	147	6	l.	l.	PROPN
gs-3688	147	7	;	;	PUNCT
gs-3688	147	8	yu	yu	PROPN
gs-3688	147	9	,	,	PUNCT
gs-3688	147	10	q.	q.	PROPN
gs-3688	147	11	;	;	PUNCT
gs-3688	147	12	peng	peng	PROPN
gs-3688	147	13	,	,	PUNCT
gs-3688	147	14	f.	f.	PROPN
gs-3688	147	15	;	;	PUNCT
gs-3688	147	16	sun	sun	PROPN
gs-3688	147	17	,	,	PUNCT
gs-3688	147	18	c.	c.	PROPN
gs-3688	147	19	;	;	PUNCT
gs-3688	147	20	wang	wang	PROPN
gs-3688	147	21	,	,	PUNCT
gs-3688	147	22	d.	d.	PROPN
gs-3688	147	23	;	;	PUNCT
gs-3688	147	24	pu	pu	PROPN
gs-3688	147	25	,	,	PUNCT
gs-3688	147	26	l.	l.	PROPN
gs-3688	147	27	;	;	PUNCT
gs-3688	147	28	xiong	xiong	PROPN
gs-3688	147	29	,	,	PUNCT
gs-3688	147	30	f.	f.	PROPN
gs-3688	147	31	;	;	PUNCT
gs-3688	147	32	tian	tian	PROPN
gs-3688	147	33	,	,	PUNCT
gs-3688	147	34	y.	y.	PROPN
gs-3688	147	35	;	;	PUNCT
gs-3688	147	36	peng	peng	PROPN
gs-3688	147	37	,	,	PUNCT
gs-3688	147	38	c.	c.	PROPN
gs-3688	147	39	;	;	PUNCT
gs-3688	147	40	zhou	zhou	PROPN
gs-3688	147	41	,	,	PUNCT
gs-3688	147	42	q.	q.	VERB
gs-3688	147	43	the	the	DET
gs-3688	147	44	antibacterial	antibacterial	ADJ
gs-3688	147	45	activity	activity	NOUN
gs-3688	147	46	of	of	ADP
gs-3688	147	47	berberine	berberine	NOUN
gs-3688	147	48	against	against	ADP
gs-3688	147	49	cutibacterium	cutibacterium	ADJ
gs-3688	147	50	acnes	acne	NOUN
gs-3688	147	51	:	:	PUNCT
gs-3688	147	52	its	its	PRON
gs-3688	147	53	therapeutic	therapeutic	ADJ
gs-3688	147	54	potential	potential	NOUN
gs-3688	147	55	in	in	ADP
gs-3688	147	56	inflammatory	inflammatory	ADJ
gs-3688	147	57	acne	acne	NOUN
gs-3688	147	58	.	.	PUNCT
gs-3688	148	1	frontiers	frontier	NOUN
gs-3688	148	2	in	in	ADP
gs-3688	148	3	microbiology	microbiology	NOUN
gs-3688	148	4	2024	2024	NUM
gs-3688	148	5	,	,	PUNCT
gs-3688	148	6	14	14	NUM
gs-3688	148	7	.	.	PUNCT
gs-3688	149	1	https://doi.org/10.3389/fmicb.2023.1276383	https://doi.org/10.3389/fmicb.2023.1276383	PROPN
gs-3688	149	2	.	.	PUNCT
gs-3688	150	1	(	(	PUNCT
gs-3688	150	2	15	15	NUM
gs-3688	150	3	)	)	PUNCT
gs-3688	150	4	xie	xie	PROPN
gs-3688	150	5	,	,	PUNCT
gs-3688	150	6	w.	w.	PROPN
gs-3688	150	7	;	;	PUNCT
gs-3688	150	8	su	su	PROPN
gs-3688	150	9	,	,	PUNCT
gs-3688	150	10	f.	f.	PROPN
gs-3688	150	11	;	;	PUNCT
gs-3688	150	12	wang	wang	PROPN
gs-3688	150	13	,	,	PUNCT
gs-3688	150	14	g.	g.	PROPN
gs-3688	150	15	;	;	PUNCT
gs-3688	150	16	peng	peng	PROPN
gs-3688	150	17	,	,	PUNCT
gs-3688	150	18	z.	z.	PROPN
gs-3688	150	19	;	;	PUNCT
gs-3688	150	20	xu	xu	INTJ
gs-3688	150	21	,	,	PUNCT
gs-3688	150	22	y.	y.	PROPN
gs-3688	150	23	;	;	PUNCT
gs-3688	150	24	zhang	zhang	PROPN
gs-3688	150	25	,	,	PUNCT
gs-3688	150	26	y.	y.	PROPN
gs-3688	150	27	;	;	PUNCT
gs-3688	150	28	xu	xu	PROPN
gs-3688	150	29	,	,	PUNCT
gs-3688	150	30	n.	n.	PROPN
gs-3688	150	31	;	;	PUNCT
gs-3688	150	32	hou	hou	PROPN
gs-3688	150	33	,	,	PUNCT
gs-3688	150	34	k.	k.	PROPN
gs-3688	150	35	;	;	PUNCT
gs-3688	150	36	hu	hu	PROPN
gs-3688	150	37	,	,	PUNCT
gs-3688	150	38	z.	z.	PROPN
gs-3688	150	39	;	;	PUNCT
gs-3688	150	40	chen	chen	PROPN
gs-3688	150	41	,	,	PUNCT
gs-3688	150	42	y.	y.	PROPN
gs-3688	150	43	;	;	PUNCT
gs-3688	150	44	chen	chen	PROPN
gs-3688	150	45	,	,	PUNCT
gs-3688	150	46	r.	r.	PROPN
gs-3688	150	47	glucose	glucose	NOUN
gs-3688	150	48	-	-	PUNCT
gs-3688	150	49	lowering	lower	VERB
gs-3688	150	50	effect	effect	NOUN
gs-3688	150	51	of	of	ADP
gs-3688	150	52	berberine	berberine	NOUN
gs-3688	150	53	on	on	ADP
gs-3688	150	54	type	type	NOUN
gs-3688	150	55	2	2	NUM
gs-3688	150	56	diabetes	diabetes	NOUN
gs-3688	150	57	:	:	PUNCT
gs-3688	150	58	a	a	DET
gs-3688	150	59	systematic	systematic	ADJ
gs-3688	150	60	review	review	NOUN
gs-3688	150	61	and	and	CCONJ
gs-3688	150	62	meta	meta	ADJ
gs-3688	150	63	-	-	PUNCT
gs-3688	150	64	analysis	analysis	NOUN
gs-3688	150	65	.	.	PUNCT
gs-3688	151	1	frontiers	frontier	NOUN
gs-3688	151	2	in	in	ADP
gs-3688	151	3	pharmacology	pharmacology	NOUN
gs-3688	151	4	2022	2022	NUM
gs-3688	151	5	,	,	PUNCT
gs-3688	151	6	13	13	NUM
gs-3688	151	7	,	,	PUNCT
gs-3688	151	8	1015045	1015045	NUM
gs-3688	151	9	.	.	PUNCT
gs-3688	152	1	https://doi.org/10.3389/fphar.2022.1015045	https://doi.org/10.3389/fphar.2022.1015045	PROPN
gs-3688	152	2	.	.	PUNCT
gs-3688	153	1	(	(	PUNCT
gs-3688	153	2	16	16	NUM
gs-3688	153	3	)	)	PUNCT
gs-3688	153	4	li	li	PROPN
gs-3688	153	5	,	,	PUNCT
gs-3688	153	6	d.-d	d.-d	PROPN
gs-3688	153	7	.	.	PUNCT
gs-3688	153	8	;	;	PUNCT
gs-3688	153	9	yu	yu	PROPN
gs-3688	153	10	,	,	PUNCT
gs-3688	153	11	p.	p.	PROPN
gs-3688	153	12	;	;	PUNCT
gs-3688	153	13	xiao	xiao	PROPN
gs-3688	153	14	,	,	PUNCT
gs-3688	153	15	w.	w.	PROPN
gs-3688	153	16	;	;	PUNCT
gs-3688	153	17	wang	wang	PROPN
gs-3688	153	18	,	,	PUNCT
gs-3688	153	19	z.-z	z.-z	PROPN
gs-3688	153	20	.	.	PUNCT
gs-3688	153	21	;	;	PUNCT
gs-3688	154	1	zhao	zhao	X
gs-3688	154	2	,	,	PUNCT
gs-3688	154	3	l.-g	l.-g	PROPN
gs-3688	154	4	.	.	PUNCT
gs-3688	155	1	berberine	berberine	NOUN
gs-3688	155	2	:	:	PUNCT
gs-3688	155	3	a	a	DET
gs-3688	155	4	promising	promising	ADJ
gs-3688	155	5	natural	natural	ADJ
gs-3688	155	6	isoquinoline	isoquinoline	ADJ
gs-3688	155	7	alkaloid	alkaloid	NOUN
gs-3688	155	8	for	for	ADP
gs-3688	155	9	the	the	DET
gs-3688	155	10	development	development	NOUN
gs-3688	155	11	of	of	ADP
gs-3688	155	12	hypolipidemic	hypolipidemic	ADJ
gs-3688	155	13	drugs	drug	NOUN
gs-3688	155	14	.	.	PUNCT
gs-3688	156	1	current	current	ADJ
gs-3688	156	2	topics	topic	NOUN
gs-3688	156	3	in	in	ADP
gs-3688	156	4	medicinal	medicinal	ADJ
gs-3688	156	5	chemistry	chemistry	NOUN
gs-3688	156	6	2020	2020	NUM
gs-3688	156	7	,	,	PUNCT
gs-3688	156	8	20	20	NUM
gs-3688	156	9	(	(	PUNCT
gs-3688	156	10	28	28	NUM
gs-3688	156	11	)	)	PUNCT
gs-3688	156	12	,	,	PUNCT
gs-3688	156	13	2634–2647	2634–2647	NUM
gs-3688	156	14	.	.	PUNCT
gs-3688	157	1	https://doi.org/10.2174/1568026620666200908165913	https://doi.org/10.2174/1568026620666200908165913	PROPN
gs-3688	157	2	.	.	PUNCT
gs-3688	158	1	(	(	PUNCT
gs-3688	158	2	17	17	NUM
gs-3688	158	3	)	)	PUNCT
gs-3688	158	4	gao	gao	PROPN
gs-3688	158	5	,	,	PUNCT
gs-3688	158	6	y.	y.	PROPN
gs-3688	158	7	;	;	PUNCT
gs-3688	158	8	nie	nie	PROPN
gs-3688	158	9	,	,	PUNCT
gs-3688	158	10	k.	k.	PROPN
gs-3688	158	11	;	;	PUNCT
gs-3688	158	12	wang	wang	PROPN
gs-3688	158	13	,	,	PUNCT
gs-3688	158	14	h.	h.	PROPN
gs-3688	158	15	;	;	PUNCT
gs-3688	158	16	dong	dong	PROPN
gs-3688	158	17	,	,	PUNCT
gs-3688	158	18	h.	h.	PROPN
gs-3688	158	19	;	;	PUNCT
gs-3688	158	20	tang	tang	PROPN
gs-3688	158	21	,	,	PUNCT
gs-3688	158	22	y.	y.	PROPN
gs-3688	158	23	research	research	NOUN
gs-3688	158	24	progress	progress	NOUN
gs-3688	158	25	on	on	ADP
gs-3688	158	26	antidepressant	antidepressant	ADJ
gs-3688	158	27	effects	effect	NOUN
gs-3688	158	28	and	and	CCONJ
gs-3688	158	29	mechanisms	mechanism	NOUN
gs-3688	158	30	of	of	ADP
gs-3688	158	31	berberine	berberine	NOUN
gs-3688	158	32	.	.	PUNCT
gs-3688	159	1	frontiers	frontier	NOUN
gs-3688	159	2	in	in	ADP
gs-3688	159	3	pharmacology	pharmacology	NOUN
gs-3688	159	4	2024	2024	NUM
gs-3688	159	5	,	,	PUNCT
gs-3688	159	6	15	15	NUM
gs-3688	159	7	.	.	PUNCT
gs-3688	160	1	https://doi.org/10.3389/fphar.2024.1331440	https://doi.org/10.3389/fphar.2024.1331440	PROPN
gs-3688	160	2	.	.	PUNCT
gs-3688	161	1	(	(	PUNCT
gs-3688	161	2	18	18	NUM
gs-3688	161	3	)	)	PUNCT
gs-3688	161	4	yu	yu	PROPN
gs-3688	161	5	,	,	PUNCT
gs-3688	161	6	m.	m.	NOUN
gs-3688	161	7	;	;	PUNCT
gs-3688	161	8	jin	jin	NOUN
gs-3688	161	9	,	,	PUNCT
gs-3688	161	10	x.	x.	PROPN
gs-3688	161	11	;	;	PUNCT
gs-3688	161	12	liang	liang	PROPN
gs-3688	161	13	,	,	PUNCT
gs-3688	161	14	c.	c.	PROPN
gs-3688	161	15	;	;	PUNCT
gs-3688	161	16	bu	bu	PROPN
gs-3688	161	17	,	,	PUNCT
gs-3688	161	18	f.	f.	PROPN
gs-3688	161	19	;	;	PUNCT
gs-3688	161	20	pan	pan	PROPN
gs-3688	161	21	,	,	PUNCT
gs-3688	161	22	d.	d.	PROPN
gs-3688	161	23	;	;	PUNCT
gs-3688	161	24	he	he	PRON
gs-3688	161	25	,	,	PUNCT
gs-3688	161	26	q.	q.	PROPN
gs-3688	161	27	;	;	PUNCT
gs-3688	161	28	ming	ming	PROPN
gs-3688	161	29	,	,	PUNCT
gs-3688	161	30	y.	y.	PROPN
gs-3688	161	31	;	;	PUNCT
gs-3688	161	32	little	little	ADJ
gs-3688	161	33	,	,	PUNCT
gs-3688	161	34	p.	p.	NOUN
gs-3688	161	35	;	;	PUNCT
gs-3688	161	36	du	du	PROPN
gs-3688	161	37	,	,	PUNCT
gs-3688	161	38	h.	h.	PROPN
gs-3688	161	39	;	;	PUNCT
gs-3688	161	40	liang	liang	PROPN
gs-3688	161	41	,	,	PUNCT
gs-3688	161	42	s.	s.	PROPN
gs-3688	161	43	;	;	PUNCT
gs-3688	161	44	hu	hu	PROPN
gs-3688	161	45	,	,	PUNCT
gs-3688	161	46	r.	r.	PROPN
gs-3688	161	47	;	;	PUNCT
gs-3688	161	48	li	li	PROPN
gs-3688	161	49	,	,	PUNCT
gs-3688	161	50	c.	c.	PROPN
gs-3688	161	51	;	;	PUNCT
gs-3688	161	52	hu	hu	PROPN
gs-3688	161	53	,	,	PUNCT
gs-3688	161	54	y.	y.	PROPN
gs-3688	161	55	j.	j.	PROPN
gs-3688	161	56	;	;	PUNCT
gs-3688	161	57	cao	cao	PROPN
gs-3688	161	58	,	,	PUNCT
gs-3688	161	59	h.	h.	PROPN
gs-3688	161	60	;	;	PUNCT
gs-3688	161	61	liu	liu	PROPN
gs-3688	161	62	,	,	PUNCT
gs-3688	161	63	j.	j.	PROPN
gs-3688	161	64	;	;	PUNCT
gs-3688	161	65	fei	fei	PROPN
gs-3688	161	66	,	,	PUNCT
gs-3688	161	67	y.	y.	PROPN
gs-3688	161	68	berberine	berberine	PROPN
gs-3688	161	69	for	for	ADP
gs-3688	161	70	diarrhea	diarrhea	NOUN
gs-3688	161	71	in	in	ADP
gs-3688	161	72	children	child	NOUN
gs-3688	161	73	and	and	CCONJ
gs-3688	161	74	adults	adult	NOUN
gs-3688	161	75	:	:	PUNCT
gs-3688	161	76	a	a	DET
gs-3688	161	77	systematic	systematic	ADJ
gs-3688	161	78	review	review	NOUN
gs-3688	161	79	and	and	CCONJ
gs-3688	161	80	meta	meta	ADJ
gs-3688	161	81	-	-	PUNCT
gs-3688	161	82	analysis	analysis	NOUN
gs-3688	161	83	.	.	PUNCT
gs-3688	162	1	therapeutic	therapeutic	ADJ
gs-3688	162	2	advances	advance	NOUN
gs-3688	162	3	in	in	ADP
gs-3688	162	4	gastroenterology	gastroenterology	NOUN
gs-3688	162	5	2020	2020	NUM
gs-3688	162	6	,	,	PUNCT
gs-3688	162	7	13	13	NUM
gs-3688	162	8	,	,	PUNCT
gs-3688	162	9	1756284820961299	1756284820961299	NUM
gs-3688	162	10	.	.	PUNCT
gs-3688	163	1	https://doi.org/10.1177/1756284820961299	https://doi.org/10.1177/1756284820961299	ADV
gs-3688	163	2	.	.	PUNCT
gs-3688	164	1	(	(	PUNCT
gs-3688	164	2	19	19	NUM
gs-3688	164	3	)	)	PUNCT
gs-3688	164	4	almatroodi	almatroodi	NOUN
gs-3688	164	5	,	,	PUNCT
gs-3688	164	6	s.	s.	PROPN
gs-3688	164	7	a.	a.	PROPN
gs-3688	164	8	;	;	PUNCT
gs-3688	164	9	alsahli	alsahli	NOUN
gs-3688	164	10	,	,	PUNCT
gs-3688	164	11	m.	m.	NOUN
gs-3688	164	12	a.	a.	PROPN
gs-3688	164	13	;	;	PUNCT
gs-3688	164	14	arshad	arshad	PROPN
gs-3688	164	15	husain	husain	PROPN
gs-3688	164	16	rahmani	rahmani	PROPN
gs-3688	164	17	.	.	PUNCT
gs-3688	165	1	berberine	berberine	NOUN
gs-3688	165	2	:	:	PUNCT
gs-3688	165	3	an	an	DET
gs-3688	165	4	important	important	ADJ
gs-3688	165	5	emphasis	emphasis	NOUN
gs-3688	165	6	on	on	ADP
gs-3688	165	7	its	its	PRON
gs-3688	165	8	anticancer	anticancer	NOUN
gs-3688	165	9	effects	effect	NOUN
gs-3688	165	10	through	through	ADP
gs-3688	165	11	modulation	modulation	NOUN
gs-3688	165	12	of	of	ADP
gs-3688	165	13	various	various	ADJ
gs-3688	165	14	cell	cell	NOUN
gs-3688	165	15	signaling	signal	VERB
gs-3688	165	16	pathways	pathway	NOUN
gs-3688	165	17	.	.	PUNCT
gs-3688	166	1	molecules	molecule	NOUN
gs-3688	166	2	2022	2022	NUM
gs-3688	166	3	,	,	PUNCT
gs-3688	166	4	27	27	NUM
gs-3688	166	5	(	(	PUNCT
gs-3688	166	6	18	18	NUM
gs-3688	166	7	)	)	PUNCT
gs-3688	166	8	,	,	PUNCT
gs-3688	166	9	5889–5889	5889–5889	NUM
gs-3688	166	10	.	.	PUNCT
gs-3688	167	1	https://doi.org/10.3390/molecules27185889	https://doi.org/10.3390/molecules27185889	NOUN
gs-3688	167	2	.	.	PUNCT
gs-3688	168	1	(	(	PUNCT
gs-3688	168	2	20	20	NUM
gs-3688	168	3	)	)	PUNCT
gs-3688	168	4	liu	liu	PROPN
gs-3688	168	5	,	,	PUNCT
gs-3688	168	6	y.	y.	PROPN
gs-3688	168	7	;	;	PUNCT
gs-3688	168	8	nwafor	nwafor	PROPN
gs-3688	168	9	,	,	PUNCT
gs-3688	168	10	e.-o	e.-o	NOUN
gs-3688	168	11	.	.	PUNCT
gs-3688	168	12	;	;	PUNCT
gs-3688	169	1	li	li	PROPN
gs-3688	169	2	,	,	PUNCT
gs-3688	169	3	z.	z.	PROPN
gs-3688	169	4	;	;	PUNCT
gs-3688	169	5	wang	wang	PROPN
gs-3688	169	6	,	,	PUNCT
gs-3688	169	7	j.	j.	PROPN
gs-3688	169	8	;	;	PUNCT
gs-3688	169	9	liu	liu	PROPN
gs-3688	169	10	,	,	PUNCT
gs-3688	169	11	z.	z.	PROPN
gs-3688	169	12	effects	effect	NOUN
gs-3688	169	13	of	of	ADP
gs-3688	169	14	berberine	berberine	NOUN
gs-3688	169	15	on	on	ADP
gs-3688	169	16	liver	liver	NOUN
gs-3688	169	17	cancer	cancer	NOUN
gs-3688	169	18	.	.	PUNCT
gs-3688	170	1	natural	natural	ADJ
gs-3688	170	2	product	product	NOUN
gs-3688	170	3	communications	communication	NOUN
gs-3688	170	4	2022	2022	NUM
gs-3688	170	5	,	,	PUNCT
gs-3688	170	6	17	17	NUM
gs-3688	170	7	(	(	PUNCT
gs-3688	170	8	5	5	NUM
gs-3688	170	9	)	)	PUNCT
gs-3688	170	10	,	,	PUNCT
gs-3688	170	11	1934578x2211020	1934578x2211020	NUM
gs-3688	170	12	.	.	PUNCT
gs-3688	170	13	https://doi.org/10.1177/1934578x221102032	https://doi.org/10.1177/1934578x221102032	PROPN
gs-3688	170	14	.	.	PUNCT
gs-3688	171	1	(	(	PUNCT
gs-3688	171	2	21	21	NUM
gs-3688	171	3	)	)	PUNCT
gs-3688	171	4	xiong	xiong	PROPN
gs-3688	171	5	,	,	PUNCT
gs-3688	171	6	r.-g	r.-g	PROPN
gs-3688	171	7	.	.	PUNCT
gs-3688	171	8	;	;	PUNCT
gs-3688	171	9	huang	huang	PROPN
gs-3688	171	10	,	,	PUNCT
gs-3688	171	11	s.-y	s.-y	NOUN
gs-3688	171	12	.	.	PUNCT
gs-3688	171	13	;	;	PUNCT
gs-3688	171	14	wu	wu	PROPN
gs-3688	171	15	,	,	PUNCT
gs-3688	171	16	s.-x	s.-x	NOUN
gs-3688	171	17	.	.	PUNCT
gs-3688	171	18	;	;	PUNCT
gs-3688	172	1	zhou	zhou	PROPN
gs-3688	172	2	,	,	PUNCT
gs-3688	172	3	d.-d	d.-d	PROPN
gs-3688	172	4	.	.	PUNCT
gs-3688	172	5	;	;	PUNCT
gs-3688	172	6	yang	yang	PROPN
gs-3688	172	7	,	,	PUNCT
gs-3688	172	8	z.-j	z.-j	PROPN
gs-3688	172	9	.	.	PROPN
gs-3688	172	10	;	;	PUNCT
gs-3688	172	11	saimaiti	saimaiti	PROPN
gs-3688	172	12	,	,	PUNCT
gs-3688	172	13	a.	a.	PROPN
gs-3688	172	14	;	;	PUNCT
gs-3688	172	15	zhao	zhao	X
gs-3688	172	16	,	,	PUNCT
gs-3688	172	17	c.-n	c.-n	PROPN
gs-3688	172	18	.	.	PUNCT
gs-3688	172	19	;	;	PUNCT
gs-3688	172	20	shang	shang	PROPN
gs-3688	172	21	,	,	PUNCT
gs-3688	172	22	a.	a.	PROPN
gs-3688	172	23	;	;	PUNCT
gs-3688	172	24	zhang	zhang	PROPN
gs-3688	172	25	,	,	PUNCT
gs-3688	172	26	y.-j	y.-j	PROPN
gs-3688	172	27	.	.	PROPN
gs-3688	172	28	;	;	PUNCT
gs-3688	172	29	gan	gin	VERB
gs-3688	172	30	,	,	PUNCT
gs-3688	172	31	r.-y	r.-y	NOUN
gs-3688	172	32	.	.	PUNCT
gs-3688	172	33	;	;	PUNCT
gs-3688	172	34	li	li	PROPN
gs-3688	172	35	,	,	PUNCT
gs-3688	172	36	h.-b	h.-b	PROPN
gs-3688	172	37	.	.	PUNCT
gs-3688	173	1	anticancer	anticancer	NOUN
gs-3688	173	2	effects	effect	NOUN
gs-3688	173	3	and	and	CCONJ
gs-3688	173	4	mechanisms	mechanism	NOUN
gs-3688	173	5	of	of	ADP
gs-3688	173	6	berberine	berberine	NOUN
gs-3688	173	7	from	from	ADP
gs-3688	173	8	medicinal	medicinal	ADJ
gs-3688	173	9	herbs	herb	NOUN
gs-3688	173	10	:	:	PUNCT
gs-3688	173	11	an	an	DET
gs-3688	173	12	update	update	NOUN
gs-3688	173	13	review	review	NOUN
gs-3688	173	14	.	.	PUNCT
gs-3688	174	1	molecules	molecule	NOUN
gs-3688	174	2	(	(	PUNCT
gs-3688	174	3	basel	basel	PROPN
gs-3688	174	4	,	,	PUNCT
gs-3688	174	5	switzerland	switzerland	PROPN
gs-3688	174	6	)	)	PUNCT
gs-3688	174	7	2022	2022	NUM
gs-3688	174	8	,	,	PUNCT
gs-3688	174	9	27	27	NUM
gs-3688	174	10	(	(	PUNCT
gs-3688	174	11	14	14	NUM
gs-3688	174	12	)	)	PUNCT
gs-3688	174	13	,	,	PUNCT
gs-3688	174	14	4523	4523	NUM
gs-3688	174	15	.	.	PUNCT
gs-3688	175	1	https://doi.org/10.3390/molecules27144523	https://doi.org/10.3390/molecules27144523	NOUN
gs-3688	175	2	.	.	PUNCT
gs-3688	176	1	(	(	PUNCT
gs-3688	176	2	22	22	NUM
gs-3688	176	3	)	)	PUNCT
gs-3688	176	4	jiang	jiang	PROPN
gs-3688	176	5	,	,	PUNCT
gs-3688	176	6	s.-x	s.-x	NOUN
gs-3688	176	7	.	.	PUNCT
gs-3688	176	8	;	;	PUNCT
gs-3688	176	9	qi	qi	PROPN
gs-3688	176	10	,	,	PUNCT
gs-3688	176	11	b.	b.	PROPN
gs-3688	176	12	;	;	PUNCT
gs-3688	176	13	yao	yao	PROPN
gs-3688	176	14	,	,	PUNCT
gs-3688	176	15	w.-j	w.-j	PROPN
gs-3688	176	16	.	.	PROPN
gs-3688	176	17	;	;	PUNCT
gs-3688	177	1	gu	gu	PROPN
gs-3688	177	2	,	,	PUNCT
gs-3688	177	3	c.-w	c.-w	PROPN
gs-3688	177	4	.	.	PUNCT
gs-3688	177	5	;	;	PUNCT
gs-3688	178	1	wei	wei	PROPN
gs-3688	178	2	,	,	PUNCT
gs-3688	178	3	x.-f	x.-f	NOUN
gs-3688	178	4	.	.	PUNCT
gs-3688	178	5	;	;	PUNCT
gs-3688	178	6	zhao	zhao	X
gs-3688	178	7	,	,	PUNCT
gs-3688	178	8	y.	y.	PROPN
gs-3688	178	9	;	;	PUNCT
gs-3688	178	10	liu	liu	PROPN
gs-3688	178	11	,	,	PUNCT
gs-3688	178	12	y.-z	y.-z	PROPN
gs-3688	178	13	.	.	PUNCT
gs-3688	178	14	;	;	PUNCT
gs-3688	178	15	zhao	zhao	X
gs-3688	178	16	,	,	PUNCT
gs-3688	178	17	b.-s	b.-s	PROPN
gs-3688	178	18	.	.	PUNCT
gs-3688	179	1	berberine	berberine	NOUN
gs-3688	179	2	displays	display	VERB
gs-3688	179	3	antitumor	antitumor	PROPN
gs-3688	179	4	activity	activity	NOUN
gs-3688	179	5	in	in	ADP
gs-3688	179	6	esophageal	esophageal	ADJ
gs-3688	179	7	cancer	cancer	NOUN
gs-3688	179	8	cells	cell	NOUN
gs-3688	179	9	in	in	ADP
gs-3688	179	10	vitro	vitro	X
gs-3688	179	11	.	.	PUNCT
gs-3688	180	1	world	world	PROPN
gs-3688	180	2	journal	journal	PROPN
gs-3688	180	3	of	of	ADP
gs-3688	180	4	gastroenterology	gastroenterology	NOUN
gs-3688	180	5	2017	2017	NUM
gs-3688	180	6	,	,	PUNCT
gs-3688	180	7	23	23	NUM
gs-3688	180	8	(	(	PUNCT
gs-3688	180	9	14	14	NUM
gs-3688	180	10	)	)	PUNCT
gs-3688	180	11	,	,	PUNCT
gs-3688	180	12	2511–2511	2511–2511	NUM
gs-3688	180	13	.	.	PUNCT
gs-3688	181	1	https://doi.org/10.3748/wjg.v23.i14.2511	https://doi.org/10.3748/wjg.v23.i14.2511	X
gs-3688	181	2	.	.	PUNCT
gs-3688	182	1	(	(	PUNCT
gs-3688	182	2	23	23	NUM
gs-3688	182	3	)	)	PUNCT
gs-3688	182	4	yamashita	yamashita	PROPN
gs-3688	182	5	,	,	PUNCT
gs-3688	182	6	a.	a.	PROPN
gs-3688	182	7	;	;	PUNCT
gs-3688	182	8	kasai	kasai	PROPN
gs-3688	182	9	,	,	PUNCT
gs-3688	182	10	h.	h.	PROPN
gs-3688	182	11	;	;	PUNCT
gs-3688	182	12	maekawa	maekawa	PROPN
gs-3688	182	13	,	,	PUNCT
gs-3688	182	14	s.	s.	PROPN
gs-3688	182	15	;	;	PUNCT
gs-3688	182	16	tanaka	tanaka	PROPN
gs-3688	182	17	,	,	PUNCT
gs-3688	182	18	t.	t.	PROPN
gs-3688	182	19	;	;	PUNCT
gs-3688	182	20	yasunori	yasunori	PROPN
gs-3688	182	21	akaike	akaike	PROPN
gs-3688	182	22	;	;	PUNCT
gs-3688	182	23	akihide	akihide	PROPN
gs-3688	182	24	ryo	ryo	PROPN
gs-3688	182	25	;	;	PUNCT
gs-3688	182	26	enomoto	enomoto	NOUN
gs-3688	182	27	,	,	PUNCT
gs-3688	182	28	n.	n.	NOUN
gs-3688	182	29	;	;	PUNCT
gs-3688	182	30	kohji	kohji	PROPN
gs-3688	182	31	moriishi	moriishi	PROPN
gs-3688	182	32	.	.	PUNCT
gs-3688	183	1	berberine	berberine	PROPN
gs-3688	183	2	promotes	promote	VERB
gs-3688	183	3	k48	k48	NOUN
gs-3688	183	4	-	-	PUNCT
gs-3688	183	5	linked	link	VERB
gs-3688	183	6	polyubiquitination	polyubiquitination	NOUN
gs-3688	183	7	of	of	ADP
gs-3688	183	8	hnf4α	hnf4α	PROPN
gs-3688	183	9	,	,	PUNCT
gs-3688	183	10	leading	lead	VERB
gs-3688	183	11	to	to	ADP
gs-3688	183	12	the	the	DET
gs-3688	183	13	inhibition	inhibition	NOUN
gs-3688	183	14	of	of	ADP
gs-3688	183	15	hbv	hbv	NOUN
gs-3688	183	16	replication	replication	NOUN
gs-3688	183	17	.	.	PUNCT
gs-3688	184	1	antiviral	antiviral	ADJ
gs-3688	184	2	research	research	PROPN
gs-3688	184	3	2024	2024	NUM
gs-3688	184	4	,	,	PUNCT
gs-3688	184	5	232	232	NUM
gs-3688	184	6	,	,	PUNCT
gs-3688	184	7	106027–106027	106027–106027	NUM
gs-3688	184	8	.	.	PUNCT
gs-3688	185	1	https://doi.org/10.1016/j.antiviral.2024.106027	https://doi.org/10.1016/j.antiviral.2024.106027	PROPN
gs-3688	185	2	.	.	PUNCT
gs-3688	186	1	(	(	PUNCT
gs-3688	186	2	24	24	NUM
gs-3688	186	3	)	)	PUNCT
gs-3688	186	4	liu	liu	PROPN
gs-3688	186	5	,	,	PUNCT
gs-3688	186	6	x.	x.	PROPN
gs-3688	186	7	;	;	PUNCT
gs-3688	186	8	wang	wang	PROPN
gs-3688	186	9	,	,	PUNCT
gs-3688	186	10	l.	l.	PROPN
gs-3688	186	11	;	;	PUNCT
gs-3688	186	12	tan	tan	PROPN
gs-3688	186	13	,	,	PUNCT
gs-3688	186	14	s.	s.	PROPN
gs-3688	186	15	;	;	PUNCT
gs-3688	186	16	chen	chen	PROPN
gs-3688	186	17	,	,	PUNCT
gs-3688	186	18	z.	z.	PROPN
gs-3688	186	19	;	;	PUNCT
gs-3688	186	20	wu	wu	PROPN
gs-3688	186	21	,	,	PUNCT
gs-3688	186	22	b.	b.	PROPN
gs-3688	186	23	;	;	PUNCT
gs-3688	186	24	wu	wu	PROPN
gs-3688	186	25	,	,	PUNCT
gs-3688	186	26	x.	x.	NOUN
gs-3688	186	27	therapeutic	therapeutic	ADJ
gs-3688	186	28	effects	effect	NOUN
gs-3688	186	29	of	of	ADP
gs-3688	186	30	berberine	berberine	NOUN
gs-3688	186	31	on	on	ADP
gs-3688	186	32	liver	liver	NOUN
gs-3688	186	33	fibrosis	fibrosis	NOUN
gs-3688	186	34	are	be	AUX
gs-3688	186	35	associated	associate	VERB
gs-3688	186	36	with	with	ADP
gs-3688	186	37	lipid	lipid	ADJ
gs-3688	186	38	metabolism	metabolism	NOUN
gs-3688	186	39	and	and	CCONJ
gs-3688	186	40	intestinal	intestinal	ADJ
gs-3688	186	41	flora	flora	NOUN
gs-3688	186	42	.	.	PUNCT
gs-3688	187	1	frontiers	frontier	NOUN
gs-3688	187	2	in	in	ADP
gs-3688	187	3	pharmacology	pharmacology	NOUN
gs-3688	187	4	2022	2022	NUM
gs-3688	187	5	,	,	PUNCT
gs-3688	187	6	georgian	georgian	ADJ
gs-3688	187	7	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3688	187	8	მეცნიერები	მეცნიერები	NOUN
gs-3688	187	9	ტ.	ტ.	VERB
gs-3688	187	10	7	7	NUM
gs-3688	187	11	n	n	DET
gs-3688	187	12	2	2	NUM
gs-3688	187	13	,	,	PUNCT
gs-3688	187	14	2025	2025	NUM
gs-3688	187	15	305	305	NUM
gs-3688	187	16	13	13	NUM
gs-3688	187	17	.	.	PUNCT
gs-3688	188	1	https://doi.org/10.3389/fphar.2022.814871	https://doi.org/10.3389/fphar.2022.814871	PROPN
gs-3688	188	2	.	.	PUNCT
gs-3688	189	1	(	(	PUNCT
gs-3688	189	2	25	25	NUM
gs-3688	189	3	)	)	PUNCT
gs-3688	189	4	wang	wang	PROPN
gs-3688	189	5	,	,	PUNCT
gs-3688	189	6	q.	q.	PROPN
gs-3688	189	7	;	;	PUNCT
gs-3688	189	8	shen	shen	PROPN
gs-3688	189	9	,	,	PUNCT
gs-3688	189	10	w.	w.	PROPN
gs-3688	189	11	;	;	PUNCT
gs-3688	189	12	shao	shao	PROPN
gs-3688	189	13	,	,	PUNCT
gs-3688	189	14	w.	w.	PROPN
gs-3688	189	15	;	;	PUNCT
gs-3688	189	16	hu	hu	PROPN
gs-3688	189	17	,	,	PUNCT
gs-3688	189	18	h.	h.	PROPN
gs-3688	189	19	berberine	berberine	PROPN
gs-3688	189	20	alleviates	alleviate	VERB
gs-3688	189	21	cholesterol	cholesterol	NOUN
gs-3688	189	22	and	and	CCONJ
gs-3688	189	23	bile	bile	NOUN
gs-3688	189	24	acid	acid	NOUN
gs-3688	189	25	metabolism	metabolism	NOUN
gs-3688	189	26	disorders	disorder	NOUN
gs-3688	189	27	induced	induce	VERB
gs-3688	189	28	by	by	ADP
gs-3688	189	29	high	high	ADJ
gs-3688	189	30	cholesterol	cholesterol	NOUN
gs-3688	189	31	diet	diet	NOUN
gs-3688	189	32	in	in	ADP
gs-3688	189	33	mice	mouse	NOUN
gs-3688	189	34	.	.	PUNCT
gs-3688	190	1	biochemical	biochemical	ADJ
gs-3688	190	2	and	and	CCONJ
gs-3688	190	3	biophysical	biophysical	ADJ
gs-3688	190	4	research	research	NOUN
gs-3688	190	5	communications	communication	NOUN
gs-3688	190	6	2024	2024	NUM
gs-3688	190	7	,	,	PUNCT
gs-3688	190	8	719	719	NUM
gs-3688	190	9	,	,	PUNCT
gs-3688	190	10	150088	150088	NUM
gs-3688	190	11	.	.	PUNCT
gs-3688	191	1	https://doi.org/10.1016/j.bbrc.2024.150088	https://doi.org/10.1016/j.bbrc.2024.150088	PROPN
gs-3688	191	2	.	.	PUNCT
gs-3688	192	1	(	(	PUNCT
gs-3688	192	2	26	26	NUM
gs-3688	192	3	)	)	PUNCT
gs-3688	192	4	bu	bu	ADP
gs-3688	192	5	,	,	PUNCT
gs-3688	192	6	p.	p.	NOUN
gs-3688	192	7	;	;	PUNCT
gs-3688	192	8	le	le	X
gs-3688	192	9	,	,	PUNCT
gs-3688	192	10	y.	y.	PROPN
gs-3688	192	11	;	;	PUNCT
gs-3688	192	12	zhang	zhang	PROPN
gs-3688	192	13	,	,	PUNCT
gs-3688	192	14	y.	y.	PROPN
gs-3688	192	15	;	;	PUNCT
gs-3688	192	16	zhang	zhang	PROPN
gs-3688	192	17	,	,	PUNCT
gs-3688	192	18	y.	y.	PROPN
gs-3688	192	19	;	;	PUNCT
gs-3688	192	20	cheng	cheng	PROPN
gs-3688	192	21	,	,	PUNCT
gs-3688	192	22	x.	x.	PROPN
gs-3688	192	23	berberine	berberine	NOUN
gs-3688	192	24	-	-	PUNCT
gs-3688	192	25	induced	induce	VERB
gs-3688	192	26	inactivation	inactivation	NOUN
gs-3688	192	27	of	of	ADP
gs-3688	192	28	signal	signal	ADJ
gs-3688	192	29	transducer	transducer	NOUN
gs-3688	192	30	and	and	CCONJ
gs-3688	192	31	activator	activator	NOUN
gs-3688	192	32	of	of	ADP
gs-3688	192	33	transcription	transcription	NOUN
gs-3688	192	34	5	5	NUM
gs-3688	192	35	signaling	signal	VERB
gs-3688	192	36	promotes	promote	VERB
gs-3688	192	37	male	male	NOUN
gs-3688	192	38	-	-	PUNCT
gs-3688	192	39	specific	specific	ADJ
gs-3688	192	40	expression	expression	NOUN
gs-3688	192	41	of	of	ADP
gs-3688	192	42	a	a	DET
gs-3688	192	43	bile	bile	NOUN
gs-3688	192	44	acid	acid	NOUN
gs-3688	192	45	uptake	uptake	ADJ
gs-3688	192	46	transporter	transporter	NOUN
gs-3688	192	47	.	.	PUNCT
gs-3688	193	1	journal	journal	NOUN
gs-3688	193	2	of	of	ADP
gs-3688	193	3	biological	biological	ADJ
gs-3688	193	4	chemistry	chemistry	NOUN
gs-3688	193	5	2017	2017	NUM
gs-3688	193	6	,	,	PUNCT
gs-3688	193	7	292	292	NUM
gs-3688	193	8	(	(	PUNCT
gs-3688	193	9	11	11	NUM
gs-3688	193	10	)	)	PUNCT
gs-3688	193	11	,	,	PUNCT
gs-3688	193	12	4602–4613	4602–4613	NUM
gs-3688	193	13	.	.	PUNCT
gs-3688	194	1	https://doi.org/10.1074/jbc.m116.757567	https://doi.org/10.1074/jbc.m116.757567	AUX
gs-3688	194	2	.	.	PUNCT
gs-3688	194	3	(	(	PUNCT
gs-3688	194	4	27	27	NUM
gs-3688	194	5	)	)	PUNCT
gs-3688	194	6	chen	chen	PROPN
gs-3688	194	7	,	,	PUNCT
gs-3688	194	8	x.-h	x.-h	PROPN
gs-3688	194	9	.	.	PUNCT
gs-3688	194	10	;	;	PUNCT
gs-3688	195	1	xiang	xiang	PROPN
gs-3688	195	2	,	,	PUNCT
gs-3688	195	3	k.-l	k.-l	PROPN
gs-3688	195	4	.	.	PUNCT
gs-3688	195	5	;	;	PUNCT
gs-3688	195	6	lian	lian	PROPN
gs-3688	195	7	,	,	PUNCT
gs-3688	195	8	l.	l.	PROPN
gs-3688	195	9	;	;	PUNCT
gs-3688	195	10	peng	peng	PROPN
gs-3688	195	11	,	,	PUNCT
gs-3688	195	12	h.-w	h.-w	PROPN
gs-3688	195	13	.	.	PUNCT
gs-3688	195	14	;	;	PUNCT
gs-3688	195	15	erst	erst	NOUN
gs-3688	195	16	,	,	PUNCT
gs-3688	195	17	a.	a.	PROPN
gs-3688	195	18	s.	s.	PROPN
gs-3688	195	19	;	;	PUNCT
gs-3688	195	20	xiang	xiang	PROPN
gs-3688	195	21	,	,	PUNCT
gs-3688	195	22	x.-g	x.-g	PROPN
gs-3688	195	23	.	.	PUNCT
gs-3688	195	24	;	;	PUNCT
gs-3688	195	25	chen	chen	PROPN
gs-3688	195	26	,	,	PUNCT
gs-3688	195	27	z.-d	z.-d	PROPN
gs-3688	195	28	.	.	PUNCT
gs-3688	195	29	;	;	PUNCT
gs-3688	195	30	wang	wang	PROPN
gs-3688	195	31	,	,	PUNCT
gs-3688	195	32	w.	w.	PROPN
gs-3688	195	33	biogeographic	biogeographic	ADJ
gs-3688	195	34	diversification	diversification	NOUN
gs-3688	195	35	of	of	ADP
gs-3688	195	36	mahonia	mahonia	NOUN
gs-3688	195	37	(	(	PUNCT
gs-3688	195	38	berberidaceae	berberidaceae	ADV
gs-3688	195	39	):	):	PUNCT
gs-3688	195	40	implications	implication	NOUN
gs-3688	195	41	for	for	ADP
gs-3688	195	42	the	the	DET
gs-3688	195	43	origin	origin	NOUN
gs-3688	195	44	and	and	CCONJ
gs-3688	195	45	evolution	evolution	NOUN
gs-3688	195	46	of	of	ADP
gs-3688	195	47	east	east	ADJ
gs-3688	195	48	asian	asian	ADJ
gs-3688	195	49	subtropical	subtropical	ADJ
gs-3688	195	50	evergreen	evergreen	NOUN
gs-3688	195	51	broadleaved	broadleave	VERB
gs-3688	195	52	forests	forest	NOUN
gs-3688	195	53	.	.	PUNCT
gs-3688	196	1	molecular	molecular	ADJ
gs-3688	196	2	phylogenetics	phylogenetic	NOUN
gs-3688	196	3	and	and	CCONJ
gs-3688	196	4	evolution	evolution	NOUN
gs-3688	196	5	2020	2020	NUM
gs-3688	196	6	,	,	PUNCT
gs-3688	196	7	151	151	NUM
gs-3688	196	8	,	,	PUNCT
gs-3688	196	9	106910	106910	NUM
gs-3688	196	10	.	.	PUNCT
gs-3688	197	1	https://doi.org/10.1016/j.ympev.2020.106910	https://doi.org/10.1016/j.ympev.2020.106910	NOUN
gs-3688	197	2	.	.	PUNCT
gs-3688	198	1	(	(	PUNCT
gs-3688	198	2	28	28	NUM
gs-3688	198	3	)	)	PUNCT
gs-3688	198	4	nika	nika	PROPN
gs-3688	198	5	todua	todua	PROPN
gs-3688	198	6	;	;	PUNCT
gs-3688	198	7	сhincharadze	сhincharadze	NOUN
gs-3688	198	8	,	,	PUNCT
gs-3688	198	9	d.	d.	PROPN
gs-3688	198	10	;	;	PUNCT
gs-3688	198	11	ketevan	ketevan	PROPN
gs-3688	198	12	mchedlidze	mchedlidze	PROPN
gs-3688	198	13	;	;	PUNCT
gs-3688	198	14	jemal	jemal	ADJ
gs-3688	198	15	aneli	aneli	ADJ
gs-3688	198	16	;	;	PUNCT
gs-3688	198	17	vachnadze	vachnadze	NOUN
gs-3688	198	18	,	,	PUNCT
gs-3688	198	19	n.	n.	NOUN
gs-3688	198	20	studying	study	VERB
gs-3688	198	21	mahonia	mahonia	NOUN
gs-3688	198	22	aquifolium	aquifolium	PROPN
gs-3688	198	23	(	(	PUNCT
gs-3688	198	24	pursh	pursh	NOUN
gs-3688	198	25	)	)	PUNCT
gs-3688	198	26	nutt	nutt	NOUN
gs-3688	198	27	.	.	PROPN
gs-3688	198	28	,	,	PUNCT
gs-3688	198	29	introduced	introduce	VERB
gs-3688	198	30	in	in	ADP
gs-3688	198	31	georgia	georgia	PROPN
gs-3688	198	32	,	,	PUNCT
gs-3688	198	33	for	for	ADP
gs-3688	198	34	the	the	DET
gs-3688	198	35	content	content	NOUN
gs-3688	198	36	of	of	ADP
gs-3688	198	37	alkaloids	alkaloid	NOUN
gs-3688	198	38	and	and	CCONJ
gs-3688	198	39	the	the	DET
gs-3688	198	40	establishment	establishment	NOUN
gs-3688	198	41	of	of	ADP
gs-3688	198	42	microstructural	microstructural	ADJ
gs-3688	198	43	diagnostic	diagnostic	ADJ
gs-3688	198	44	signs	sign	NOUN
gs-3688	198	45	of	of	ADP
gs-3688	198	46	the	the	DET
gs-3688	198	47	plant	plant	NOUN
gs-3688	198	48	.	.	PUNCT
gs-3688	199	1	experimental	experimental	PROPN
gs-3688	199	2	&	&	CCONJ
gs-3688	199	3	clinical	clinical	ADJ
gs-3688	199	4	medicine	medicine	NOUN
gs-3688	199	5	georgia	georgia	PROPN
gs-3688	199	6	2022	2022	NUM
gs-3688	199	7	.	.	PUNCT
gs-3688	200	1	https://doi.org/10.52340/jecm.2022.06.13	https://doi.org/10.52340/jecm.2022.06.13	X
gs-3688	200	2	.	.	PUNCT
gs-3688	201	1	(	(	PUNCT
gs-3688	201	2	29	29	NUM
gs-3688	201	3	)	)	PUNCT
gs-3688	201	4	he	he	PRON
gs-3688	201	5	,	,	PUNCT
gs-3688	201	6	j.-m	j.-m	PROPN
gs-3688	201	7	.	.	PUNCT
gs-3688	201	8	;	;	PUNCT
gs-3688	201	9	mu	mu	PROPN
gs-3688	201	10	,	,	PUNCT
gs-3688	201	11	q.	q.	VERB
gs-3688	201	12	the	the	DET
gs-3688	201	13	medicinal	medicinal	ADJ
gs-3688	201	14	uses	use	NOUN
gs-3688	201	15	of	of	ADP
gs-3688	201	16	the	the	DET
gs-3688	201	17	genus	genus	ADJ
gs-3688	201	18	mahonia	mahonia	NOUN
gs-3688	201	19	in	in	ADP
gs-3688	201	20	traditional	traditional	ADJ
gs-3688	201	21	chinese	chinese	ADJ
gs-3688	201	22	medicine	medicine	NOUN
gs-3688	201	23	:	:	PUNCT
gs-3688	201	24	an	an	DET
gs-3688	201	25	ethnopharmacological	ethnopharmacological	ADJ
gs-3688	201	26	,	,	PUNCT
gs-3688	201	27	phytochemical	phytochemical	ADJ
gs-3688	201	28	and	and	CCONJ
gs-3688	201	29	pharmacological	pharmacological	ADJ
gs-3688	201	30	review	review	NOUN
gs-3688	201	31	.	.	PUNCT
gs-3688	202	1	journal	journal	NOUN
gs-3688	202	2	of	of	ADP
gs-3688	202	3	ethnopharmacology	ethnopharmacology	NOUN
gs-3688	202	4	2015	2015	NUM
gs-3688	202	5	,	,	PUNCT
gs-3688	202	6	175	175	NUM
gs-3688	202	7	,	,	PUNCT
gs-3688	202	8	668–683	668–683	NUM
gs-3688	202	9	.	.	PUNCT
gs-3688	203	1	https://doi.org/10.1016/j.jep.2015.09.013	https://doi.org/10.1016/j.jep.2015.09.013	NOUN
gs-3688	203	2	.	.	PUNCT
gs-3688	204	1	(	(	PUNCT
gs-3688	204	2	30	30	NUM
gs-3688	204	3	)	)	PUNCT
gs-3688	204	4	the	the	DET
gs-3688	204	5	world	world	NOUN
gs-3688	204	6	flora	flora	NOUN
gs-3688	204	7	online	online	ADV
gs-3688	204	8	,	,	PUNCT
gs-3688	204	9	https://www.worldfloraonline.org/search?query=mahonia+aquifolium	https://www.worldfloraonline.org/search?query=mahonia+aquifolium	NOUN
gs-3688	204	10	(	(	PUNCT
gs-3688	204	11	31	31	NUM
gs-3688	204	12	)	)	PUNCT
gs-3688	204	13	xu	xu	PROPN
gs-3688	204	14	,	,	PUNCT
gs-3688	204	15	p.	p.	PROPN
gs-3688	204	16	;	;	PUNCT
gs-3688	204	17	xu	xu	PROPN
gs-3688	204	18	,	,	PUNCT
gs-3688	204	19	c.	c.	PROPN
gs-3688	204	20	;	;	PUNCT
gs-3688	204	21	li	li	PROPN
gs-3688	204	22	,	,	PUNCT
gs-3688	204	23	x.	x.	PROPN
gs-3688	204	24	;	;	PUNCT
gs-3688	204	25	li	li	PROPN
gs-3688	204	26	,	,	PUNCT
gs-3688	204	27	d.	d.	PROPN
gs-3688	204	28	;	;	PUNCT
gs-3688	204	29	li	li	PROPN
gs-3688	204	30	,	,	PUNCT
gs-3688	204	31	y.	y.	PROPN
gs-3688	204	32	;	;	PUNCT
gs-3688	204	33	jiang	jiang	PROPN
gs-3688	204	34	,	,	PUNCT
gs-3688	204	35	j.	j.	PROPN
gs-3688	204	36	;	;	PUNCT
gs-3688	204	37	yang	yang	PROPN
gs-3688	204	38	,	,	PUNCT
gs-3688	204	39	p.	p.	PROPN
gs-3688	204	40	;	;	PUNCT
gs-3688	204	41	duan	duan	PROPN
gs-3688	204	42	,	,	PUNCT
gs-3688	204	43	g.	g.	PROPN
gs-3688	204	44	rapid	rapid	ADJ
gs-3688	204	45	identification	identification	NOUN
gs-3688	204	46	of	of	ADP
gs-3688	204	47	berberine	berberine	NOUN
gs-3688	204	48	metabolites	metabolite	NOUN
gs-3688	204	49	in	in	ADP
gs-3688	204	50	rat	rat	NOUN
gs-3688	204	51	plasma	plasma	NOUN
gs-3688	204	52	by	by	ADP
gs-3688	204	53	uhplc	uhplc	PROPN
gs-3688	204	54	-	-	PUNCT
gs-3688	204	55	q	q	NOUN
gs-3688	204	56	-	-	PUNCT
gs-3688	204	57	tof	tof	PROPN
gs-3688	204	58	-	-	PUNCT
gs-3688	204	59	ms	ms	PROPN
gs-3688	204	60	.	.	PROPN
gs-3688	204	61	molecules	molecule	NOUN
gs-3688	204	62	2019	2019	NUM
gs-3688	204	63	,	,	PUNCT
gs-3688	204	64	24	24	NUM
gs-3688	204	65	(	(	PUNCT
gs-3688	204	66	10	10	NUM
gs-3688	204	67	)	)	PUNCT
gs-3688	204	68	,	,	PUNCT
gs-3688	204	69	1994	1994	NUM
gs-3688	204	70	.	.	PUNCT
gs-3688	205	1	https://doi.org/10.3390/molecules24101994	https://doi.org/10.3390/molecules24101994	PROPN