id	sid	tid	token	lemma	pos
gs-3751	1	1	microsoft	microsoft	PROPN
gs-3751	1	2	word	word	NOUN
gs-3751	1	3	fullpdf07022025	fullpdf07022025	PROPN
gs-3751	1	4	georgian	georgian	ADJ
gs-3751	1	5	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3751	1	6	მეცნიერები	მეცნიერები	NOUN
gs-3751	1	7	ტ.	ტ.	VERB
gs-3751	1	8	7	7	NUM
gs-3751	1	9	n	n	DET
gs-3751	1	10	2	2	NUM
gs-3751	1	11	,	,	PUNCT
gs-3751	1	12	2025	2025	NUM
gs-3751	1	13	329	329	NUM
gs-3751	1	14	georgian	georgian	ADJ
gs-3751	1	15	scientists	scientist	NOUN
gs-3751	1	16	ქართველი	ქართველი	ADJ
gs-3751	1	17	მეცნიერები	მეცნიერები	PROPN
gs-3751	1	18	vol	vol	NOUN
gs-3751	1	19	.	.	PUNCT
gs-3751	1	20	7	7	NUM
gs-3751	1	21	issue	issue	NOUN
gs-3751	1	22	2	2	NUM
gs-3751	1	23	,	,	PUNCT
gs-3751	1	24	2025	2025	NUM
gs-3751	1	25	https://doi.org/10.52340/gs.2025.07.02.32	https://doi.org/10.52340/gs.2025.07.02.32	X
gs-3751	1	26	exploring	explore	VERB
gs-3751	1	27	the	the	DET
gs-3751	1	28	gut	gut	NOUN
gs-3751	1	29	-	-	PUNCT
gs-3751	1	30	brain	brain	NOUN
gs-3751	1	31	axis	axis	NOUN
gs-3751	1	32	:	:	PUNCT
gs-3751	1	33	the	the	DET
gs-3751	1	34	role	role	NOUN
gs-3751	1	35	of	of	ADP
gs-3751	1	36	the	the	DET
gs-3751	1	37	microbiome	microbiome	NOUN
gs-3751	1	38	in	in	ADP
gs-3751	1	39	modulating	modulate	VERB
gs-3751	1	40	brain	brain	NOUN
gs-3751	1	41	function	function	NOUN
gs-3751	1	42	and	and	CCONJ
gs-3751	1	43	its	its	PRON
gs-3751	1	44	implications	implication	NOUN
gs-3751	1	45	in	in	ADP
gs-3751	1	46	neurodegenerative	neurodegenerative	ADJ
gs-3751	1	47	disorders	disorder	NOUN
gs-3751	1	48	like	like	ADP
gs-3751	1	49	parkinson	parkinson	NOUN
gs-3751	1	50	's	's	PART
gs-3751	1	51	and	and	CCONJ
gs-3751	1	52	alzheimer	alzheimer	NOUN
gs-3751	1	53	's	's	PART
gs-3751	1	54	and	and	CCONJ
gs-3751	1	55	pharmacotherapy	pharmacotherapy	NOUN
gs-3751	1	56	treatment	treatment	NOUN
gs-3751	1	57	strategies	strategy	NOUN
gs-3751	1	58	nodar	nodar	NOUN
gs-3751	1	59	sulashvili1	sulashvili1	PROPN
gs-3751	1	60	*	*	PROPN
gs-3751	1	61	,	,	PUNCT
gs-3751	1	62	lali	lali	PROPN
gs-3751	1	63	patsia2	patsia2	PROPN
gs-3751	1	64	,	,	PUNCT
gs-3751	1	65	awad	awad	PROPN
gs-3751	1	66	el	el	PROPN
gs-3751	1	67	-	-	PROPN
gs-3751	1	68	hakeem3	hakeem3	PROPN
gs-3751	1	69	,	,	PUNCT
gs-3751	1	70	sk	sk	ADP
gs-3751	1	71	ayaan4	ayaan4	PROPN
gs-3751	1	72	,	,	PUNCT
gs-3751	1	73	arian	arian	ADJ
gs-3751	1	74	hizomi5	hizomi5	PROPN
gs-3751	1	75	,	,	PUNCT
gs-3751	1	76	sajal	sajal	ADJ
gs-3751	1	77	agarwal6	agarwal6	PROPN
gs-3751	1	78	,	,	PUNCT
gs-3751	1	79	marika	marika	PROPN
gs-3751	1	80	sulashvili7	sulashvili7	PROPN
gs-3751	1	81	1md	1md	NOUN
gs-3751	1	82	,	,	PUNCT
gs-3751	1	83	phd	phd	NOUN
gs-3751	1	84	,	,	PUNCT
gs-3751	1	85	doctor	doctor	NOUN
gs-3751	1	86	of	of	ADP
gs-3751	1	87	pharmaceutical	pharmaceutical	ADJ
gs-3751	1	88	and	and	CCONJ
gs-3751	1	89	pharmacological	pharmacological	ADJ
gs-3751	1	90	sciences	science	NOUN
gs-3751	1	91	in	in	ADP
gs-3751	1	92	medicine	medicine	NOUN
gs-3751	1	93	,	,	PUNCT
gs-3751	1	94	invited	invite	VERB
gs-3751	1	95	lecturer	lecturer	NOUN
gs-3751	1	96	(	(	PUNCT
gs-3751	1	97	invited	invite	VERB
gs-3751	1	98	professor	professor	NOUN
gs-3751	1	99	)	)	PUNCT
gs-3751	1	100	of	of	ADP
gs-3751	1	101	scientific	scientific	ADJ
gs-3751	1	102	research	research	NOUN
gs-3751	1	103	-	-	PUNCT
gs-3751	1	104	skills	skill	NOUN
gs-3751	1	105	center	center	NOUN
gs-3751	1	106	at	at	ADP
gs-3751	1	107	tbilisi	tbilisi	PROPN
gs-3751	1	108	state	state	PROPN
gs-3751	1	109	medical	medical	PROPN
gs-3751	1	110	university	university	PROPN
gs-3751	1	111	;	;	PUNCT
gs-3751	1	112	professor	professor	NOUN
gs-3751	1	113	of	of	ADP
gs-3751	1	114	medical	medical	ADJ
gs-3751	1	115	and	and	CCONJ
gs-3751	1	116	clinical	clinical	ADJ
gs-3751	1	117	pharmacology	pharmacology	NOUN
gs-3751	1	118	of	of	ADP
gs-3751	1	119	international	international	ADJ
gs-3751	1	120	school	school	NOUN
gs-3751	1	121	of	of	ADP
gs-3751	1	122	medicine	medicine	NOUN
gs-3751	1	123	at	at	ADP
gs-3751	1	124	alte	alte	PROPN
gs-3751	1	125	university	university	PROPN
gs-3751	1	126	;	;	PUNCT
gs-3751	1	127	professor	professor	NOUN
gs-3751	1	128	of	of	ADP
gs-3751	1	129	pharmacology	pharmacology	NOUN
gs-3751	1	130	of	of	ADP
gs-3751	1	131	faculty	faculty	NOUN
gs-3751	1	132	of	of	ADP
gs-3751	1	133	medicine	medicine	NOUN
gs-3751	1	134	at	at	ADP
gs-3751	1	135	georgian	georgian	PROPN
gs-3751	1	136	national	national	PROPN
gs-3751	1	137	university	university	PROPN
gs-3751	1	138	seu	seu	NOUN
gs-3751	1	139	;	;	PUNCT
gs-3751	1	140	associate	associate	ADJ
gs-3751	1	141	affiliated	affiliate	VERB
gs-3751	1	142	professor	professor	NOUN
gs-3751	1	143	of	of	ADP
gs-3751	1	144	medical	medical	ADJ
gs-3751	1	145	pharmacology	pharmacology	NOUN
gs-3751	1	146	of	of	ADP
gs-3751	1	147	faculty	faculty	NOUN
gs-3751	1	148	of	of	ADP
gs-3751	1	149	medicine	medicine	NOUN
gs-3751	1	150	at	at	ADP
gs-3751	1	151	sulkhan	sulkhan	PROPN
gs-3751	1	152	-	-	PUNCT
gs-3751	1	153	saba	saba	PROPN
gs-3751	1	154	orbeliani	orbeliani	PROPN
gs-3751	1	155	university	university	PROPN
gs-3751	1	156	;	;	PUNCT
gs-3751	1	157	associate	associate	NOUN
gs-3751	1	158	professor	professor	NOUN
gs-3751	1	159	of	of	ADP
gs-3751	1	160	pharmacology	pharmacology	NOUN
gs-3751	1	161	of	of	ADP
gs-3751	1	162	pharmacy	pharmacy	NOUN
gs-3751	1	163	program	program	NOUN
gs-3751	1	164	at	at	ADP
gs-3751	1	165	shota	shota	PROPN
gs-3751	1	166	meskhia	meskhia	PROPN
gs-3751	1	167	zugdidi	zugdidi	PROPN
gs-3751	1	168	state	state	PROPN
gs-3751	1	169	university	university	PROPN
gs-3751	1	170	;	;	PUNCT
gs-3751	1	171	associate	associate	NOUN
gs-3751	1	172	professor	professor	NOUN
gs-3751	1	173	of	of	ADP
gs-3751	1	174	medical	medical	ADJ
gs-3751	1	175	pharmacology	pharmacology	NOUN
gs-3751	1	176	at	at	ADP
gs-3751	1	177	school	school	NOUN
gs-3751	1	178	of	of	ADP
gs-3751	1	179	medicine	medicine	NOUN
gs-3751	1	180	at	at	ADP
gs-3751	1	181	david	david	PROPN
gs-3751	1	182	aghmashenebeli	aghmashenebeli	PROPN
gs-3751	1	183	university	university	PROPN
gs-3751	1	184	of	of	ADP
gs-3751	1	185	georgia	georgia	PROPN
gs-3751	1	186	;	;	PUNCT
gs-3751	1	187	associate	associate	NOUN
gs-3751	1	188	professor	professor	NOUN
gs-3751	1	189	of	of	ADP
gs-3751	1	190	biochemistry	biochemistry	NOUN
gs-3751	1	191	and	and	CCONJ
gs-3751	1	192	pharmacology	pharmacology	NOUN
gs-3751	1	193	direction	direction	NOUN
gs-3751	1	194	of	of	ADP
gs-3751	1	195	school	school	NOUN
gs-3751	1	196	of	of	ADP
gs-3751	1	197	health	health	NOUN
gs-3751	1	198	sciences	science	NOUN
gs-3751	1	199	at	at	ADP
gs-3751	1	200	the	the	DET
gs-3751	1	201	university	university	PROPN
gs-3751	1	202	of	of	ADP
gs-3751	1	203	georgia	georgia	PROPN
gs-3751	1	204	;	;	PUNCT
gs-3751	1	205	associate	associate	NOUN
gs-3751	1	206	professor	professor	NOUN
gs-3751	1	207	of	of	ADP
gs-3751	1	208	pharmacology	pharmacology	NOUN
gs-3751	1	209	of	of	ADP
gs-3751	1	210	faculty	faculty	NOUN
gs-3751	1	211	of	of	ADP
gs-3751	1	212	medicine	medicine	NOUN
gs-3751	1	213	at	at	ADP
gs-3751	1	214	east	east	PROPN
gs-3751	1	215	european	european	PROPN
gs-3751	1	216	university	university	PROPN
gs-3751	1	217	;	;	PUNCT
gs-3751	1	218	associate	associate	NOUN
gs-3751	1	219	professor	professor	NOUN
gs-3751	1	220	of	of	ADP
gs-3751	1	221	pharmacology	pharmacology	NOUN
gs-3751	1	222	of	of	ADP
gs-3751	1	223	faculty	faculty	NOUN
gs-3751	1	224	of	of	ADP
gs-3751	1	225	dentistry	dentistry	NOUN
gs-3751	1	226	and	and	CCONJ
gs-3751	1	227	pharmacy	pharmacy	NOUN
gs-3751	1	228	at	at	ADP
gs-3751	1	229	tbilisi	tbilisi	ADJ
gs-3751	1	230	humanitarian	humanitarian	ADJ
gs-3751	1	231	teaching	teaching	NOUN
gs-3751	1	232	university	university	NOUN
gs-3751	1	233	;	;	PUNCT
gs-3751	1	234	tbilisi	tbilisi	PROPN
gs-3751	1	235	,	,	PUNCT
gs-3751	1	236	georgia	georgia	PROPN
gs-3751	1	237	;	;	PUNCT
gs-3751	1	238	researcher	researcher	NOUN
gs-3751	1	239	of	of	ADP
gs-3751	1	240	department	department	PROPN
gs-3751	1	241	of	of	ADP
gs-3751	1	242	pharmaceutical	pharmaceutical	ADJ
gs-3751	1	243	management	management	NOUN
gs-3751	1	244	of	of	ADP
gs-3751	1	245	yerevan	yerevan	PROPN
gs-3751	1	246	state	state	PROPN
gs-3751	1	247	medical	medical	PROPN
gs-3751	1	248	university	university	PROPN
gs-3751	1	249	after	after	ADP
gs-3751	1	250	mkhitar	mkhitar	NOUN
gs-3751	1	251	heratsi	heratsi	PROPN
gs-3751	1	252	,	,	PUNCT
gs-3751	1	253	yerevan	yerevan	PROPN
gs-3751	1	254	,	,	PUNCT
gs-3751	1	255	armenia	armenia	PROPN
gs-3751	1	256	.	.	PUNCT
gs-3751	2	1	orcid	orcid	PROPN
gs-3751	2	2	https://orcid.org/0000-0002-9005-8577	https://orcid.org/0000-0002-9005-8577	PROPN
gs-3751	2	3	e	e	NOUN
gs-3751	2	4	-	-	NOUN
gs-3751	2	5	mail	mail	NOUN
gs-3751	2	6	:	:	PUNCT
gs-3751	2	7	n.sulashvili@ug.edu.ge	n.sulashvili@ug.edu.ge	NOUN
gs-3751	2	8	;	;	PUNCT
gs-3751	2	9	2md	2md	NUM
gs-3751	2	10	,	,	PUNCT
gs-3751	2	11	phd	phd	NOUN
gs-3751	2	12	,	,	PUNCT
gs-3751	2	13	doctor	doctor	NOUN
gs-3751	2	14	of	of	ADP
gs-3751	2	15	medical	medical	ADJ
gs-3751	2	16	sciences	science	NOUN
gs-3751	2	17	,	,	PUNCT
gs-3751	2	18	doctor	doctor	NOUN
gs-3751	2	19	cardiologist	cardiologist	NOUN
gs-3751	2	20	at	at	ADP
gs-3751	2	21	republican	republican	ADJ
gs-3751	2	22	hospital	hospital	NOUN
gs-3751	2	23	,	,	PUNCT
gs-3751	2	24	invited	invite	VERB
gs-3751	2	25	professor	professor	NOUN
gs-3751	2	26	of	of	ADP
gs-3751	2	27	tbilisi	tbilisi	PROPN
gs-3751	2	28	state	state	PROPN
gs-3751	2	29	medical	medical	PROPN
gs-3751	2	30	university	university	PROPN
gs-3751	2	31	,	,	PUNCT
gs-3751	2	32	professor	professor	NOUN
gs-3751	2	33	of	of	ADP
gs-3751	2	34	ken	ken	PROPN
gs-3751	2	35	walker	walker	PROPN
gs-3751	2	36	international	international	PROPN
gs-3751	2	37	university	university	PROPN
gs-3751	2	38	,	,	PUNCT
gs-3751	2	39	professor	professor	NOUN
gs-3751	2	40	of	of	ADP
gs-3751	2	41	international	international	ADJ
gs-3751	2	42	school	school	NOUN
gs-3751	2	43	of	of	ADP
gs-3751	2	44	medicine	medicine	NOUN
gs-3751	2	45	at	at	ADP
gs-3751	2	46	alte	alte	PROPN
gs-3751	2	47	university	university	PROPN
gs-3751	2	48	,	,	PUNCT
gs-3751	2	49	professor	professor	NOUN
gs-3751	2	50	of	of	ADP
gs-3751	2	51	faculty	faculty	NOUN
gs-3751	2	52	of	of	ADP
gs-3751	2	53	medicine	medicine	NOUN
gs-3751	2	54	at	at	ADP
gs-3751	2	55	sulkhan	sulkhan	PROPN
gs-3751	2	56	-	-	PUNCT
gs-3751	2	57	saba	saba	PROPN
gs-3751	2	58	orbeliani	orbeliani	PROPN
gs-3751	2	59	university	university	PROPN
gs-3751	2	60	,	,	PUNCT
gs-3751	2	61	tbilisi	tbilisi	PROPN
gs-3751	2	62	,	,	PUNCT
gs-3751	2	63	georgia	georgia	PROPN
gs-3751	2	64	.	.	PUNCT
gs-3751	3	1	3medical	3medical	NUM
gs-3751	3	2	faculty	faculty	NOUN
gs-3751	3	3	student	student	NOUN
gs-3751	3	4	,	,	PUNCT
gs-3751	3	5	tbilisi	tbilisi	PROPN
gs-3751	3	6	state	state	PROPN
gs-3751	3	7	medical	medical	PROPN
gs-3751	3	8	university	university	PROPN
gs-3751	3	9	(	(	PUNCT
gs-3751	3	10	tsmu	tsmu	PROPN
gs-3751	3	11	)	)	PUNCT
gs-3751	3	12	,	,	PUNCT
gs-3751	3	13	tbilisi	tbilisi	PROPN
gs-3751	3	14	,	,	PUNCT
gs-3751	3	15	georgia	georgia	PROPN
gs-3751	3	16	;	;	PUNCT
gs-3751	3	17	4medical	4medical	NUM
gs-3751	3	18	faculty	faculty	NOUN
gs-3751	3	19	student	student	NOUN
gs-3751	3	20	,	,	PUNCT
gs-3751	3	21	tbilisi	tbilisi	PROPN
gs-3751	3	22	state	state	PROPN
gs-3751	3	23	university	university	PROPN
gs-3751	3	24	(	(	PUNCT
gs-3751	3	25	tsu	tsu	PROPN
gs-3751	3	26	)	)	PUNCT
gs-3751	3	27	,	,	PUNCT
gs-3751	3	28	tbilisi	tbilisi	PROPN
gs-3751	3	29	,	,	PUNCT
gs-3751	3	30	georgia	georgia	PROPN
gs-3751	3	31	;	;	PUNCT
gs-3751	3	32	5medical	5medical	NUM
gs-3751	3	33	faculty	faculty	NOUN
gs-3751	3	34	student	student	NOUN
gs-3751	3	35	,	,	PUNCT
gs-3751	3	36	tbilisi	tbilisi	PROPN
gs-3751	3	37	state	state	PROPN
gs-3751	3	38	university	university	PROPN
gs-3751	3	39	(	(	PUNCT
gs-3751	3	40	tsu	tsu	PROPN
gs-3751	3	41	)	)	PUNCT
gs-3751	3	42	,	,	PUNCT
gs-3751	3	43	tbilisi	tbilisi	PROPN
gs-3751	3	44	,	,	PUNCT
gs-3751	3	45	georgia	georgia	PROPN
gs-3751	3	46	;	;	PUNCT
gs-3751	3	47	6medical	6medical	NUM
gs-3751	3	48	faculty	faculty	NOUN
gs-3751	3	49	student	student	NOUN
gs-3751	3	50	,	,	PUNCT
gs-3751	3	51	tbilisi	tbilisi	PROPN
gs-3751	3	52	state	state	PROPN
gs-3751	3	53	medical	medical	PROPN
gs-3751	3	54	university	university	PROPN
gs-3751	3	55	(	(	PUNCT
gs-3751	3	56	tsmu	tsmu	PROPN
gs-3751	3	57	)	)	PUNCT
gs-3751	3	58	,	,	PUNCT
gs-3751	3	59	tbilisi	tbilisi	PROPN
gs-3751	3	60	,	,	PUNCT
gs-3751	3	61	georgia	georgia	PROPN
gs-3751	3	62	;	;	PUNCT
gs-3751	3	63	7md	7md	NOUN
gs-3751	3	64	,	,	PUNCT
gs-3751	3	65	doctor	doctor	NOUN
gs-3751	3	66	of	of	ADP
gs-3751	3	67	family	family	NOUN
gs-3751	3	68	medicine	medicine	NOUN
gs-3751	3	69	,	,	PUNCT
gs-3751	3	70	invited	invite	VERB
gs-3751	3	71	lecturer	lecturer	NOUN
gs-3751	3	72	of	of	ADP
gs-3751	3	73	tbilisi	tbilisi	PROPN
gs-3751	3	74	state	state	PROPN
gs-3751	3	75	medical	medical	PROPN
gs-3751	3	76	university	university	PROPN
gs-3751	3	77	,	,	PUNCT
gs-3751	3	78	department	department	NOUN
gs-3751	3	79	of	of	ADP
gs-3751	3	80	molecular	molecular	ADJ
gs-3751	3	81	and	and	CCONJ
gs-3751	3	82	medical	medical	ADJ
gs-3751	3	83	genetics	genetic	NOUN
gs-3751	3	84	,	,	PUNCT
gs-3751	3	85	invited	invite	VERB
gs-3751	3	86	professor	professor	NOUN
gs-3751	3	87	of	of	ADP
gs-3751	3	88	biochemistry	biochemistry	NOUN
gs-3751	3	89	and	and	CCONJ
gs-3751	3	90	molecular	molecular	ADJ
gs-3751	3	91	and	and	CCONJ
gs-3751	3	92	medical	medical	ADJ
gs-3751	3	93	genetics	genetic	NOUN
gs-3751	3	94	at	at	ADP
gs-3751	3	95	the	the	DET
gs-3751	3	96	university	university	PROPN
gs-3751	3	97	of	of	ADP
gs-3751	3	98	georgia	georgia	PROPN
gs-3751	3	99	.	.	PUNCT
gs-3751	4	1	tbilisi	tbilisi	PROPN
gs-3751	4	2	,	,	PUNCT
gs-3751	4	3	georgia	georgia	PROPN
gs-3751	4	4	.	.	PUNCT
gs-3751	5	1	https://orcid.org/0000-0002-6338-4262	https://orcid.org/0000-0002-6338-4262	PROPN
gs-3751	5	2	.	.	PUNCT
gs-3751	6	1	abstract	abstract	ADJ
gs-3751	6	2	the	the	DET
gs-3751	6	3	gut	gut	NOUN
gs-3751	6	4	-	-	PUNCT
gs-3751	6	5	brain	brain	NOUN
gs-3751	6	6	axis	axis	NOUN
gs-3751	6	7	(	(	PUNCT
gs-3751	6	8	gba	gba	NOUN
gs-3751	6	9	)	)	PUNCT
gs-3751	6	10	represents	represent	VERB
gs-3751	6	11	a	a	DET
gs-3751	6	12	dynamic	dynamic	ADJ
gs-3751	6	13	bidirectional	bidirectional	ADJ
gs-3751	6	14	communication	communication	NOUN
gs-3751	6	15	network	network	NOUN
gs-3751	6	16	linking	link	VERB
gs-3751	6	17	the	the	DET
gs-3751	6	18	gastrointestinal	gastrointestinal	ADJ
gs-3751	6	19	tract	tract	NOUN
gs-3751	6	20	and	and	CCONJ
gs-3751	6	21	the	the	DET
gs-3751	6	22	central	central	ADJ
gs-3751	6	23	nervous	nervous	ADJ
gs-3751	6	24	system	system	NOUN
gs-3751	6	25	,	,	PUNCT
gs-3751	6	26	with	with	ADP
gs-3751	6	27	the	the	DET
gs-3751	6	28	gut	gut	NOUN
gs-3751	6	29	microbiome	microbiome	NOUN
gs-3751	6	30	playing	play	VERB
gs-3751	6	31	a	a	DET
gs-3751	6	32	pivotal	pivotal	ADJ
gs-3751	6	33	role	role	NOUN
gs-3751	6	34	in	in	ADP
gs-3751	6	35	modulating	modulate	VERB
gs-3751	6	36	brain	brain	NOUN
gs-3751	6	37	function	function	NOUN
gs-3751	6	38	and	and	CCONJ
gs-3751	6	39	behavior	behavior	NOUN
gs-3751	6	40	.	.	PUNCT
gs-3751	7	1	this	this	DET
gs-3751	7	2	review	review	NOUN
gs-3751	7	3	explores	explore	VERB
gs-3751	7	4	the	the	DET
gs-3751	7	5	mechanisms	mechanism	NOUN
gs-3751	7	6	by	by	ADP
gs-3751	7	7	which	which	PRON
gs-3751	7	8	microbial	microbial	ADJ
gs-3751	7	9	communities	community	NOUN
gs-3751	7	10	influence	influence	PROPN
gs-3751	7	11	neuroinflammation	neuroinflammation	PROPN
gs-3751	7	12	,	,	PUNCT
gs-3751	7	13	synaptic	synaptic	ADJ
gs-3751	7	14	plasticity	plasticity	NOUN
gs-3751	7	15	,	,	PUNCT
gs-3751	7	16	and	and	CCONJ
gs-3751	7	17	neurodegeneration	neurodegeneration	NOUN
gs-3751	7	18	through	through	ADP
gs-3751	7	19	neural	neural	ADJ
gs-3751	7	20	,	,	PUNCT
gs-3751	7	21	endocrine	endocrine	NOUN
gs-3751	7	22	,	,	PUNCT
gs-3751	7	23	and	and	CCONJ
gs-3751	7	24	immune	immune	ADJ
gs-3751	7	25	pathways	pathway	NOUN
gs-3751	7	26	,	,	PUNCT
gs-3751	7	27	including	include	VERB
gs-3751	7	28	the	the	DET
gs-3751	7	29	production	production	NOUN
gs-3751	7	30	of	of	ADP
gs-3751	7	31	metabolites	metabolite	NOUN
gs-3751	7	32	such	such	ADJ
gs-3751	7	33	as	as	ADP
gs-3751	7	34	short	short	ADJ
gs-3751	7	35	-	-	PUNCT
gs-3751	7	36	chain	chain	NOUN
gs-3751	7	37	fatty	fatty	NOUN
gs-3751	7	38	acids	acid	NOUN
gs-3751	7	39	(	(	PUNCT
gs-3751	7	40	scfas	scfas	NOUN
gs-3751	7	41	)	)	PUNCT
gs-3751	7	42	,	,	PUNCT
gs-3751	7	43	neurotransmitters	neurotransmitter	NOUN
gs-3751	7	44	,	,	PUNCT
gs-3751	7	45	and	and	CCONJ
gs-3751	7	46	pro	pro	ADJ
gs-3751	7	47	-	-	ADJ
gs-3751	7	48	inflammatory	inflammatory	ADJ
gs-3751	7	49	cytokines	cytokine	NOUN
gs-3751	7	50	.	.	PUNCT
gs-3751	8	1	dysbiosis	dysbiosis	NOUN
gs-3751	8	2	,	,	PUNCT
gs-3751	8	3	characterized	characterize	VERB
gs-3751	8	4	by	by	ADP
gs-3751	8	5	shifts	shift	NOUN
gs-3751	8	6	in	in	ADP
gs-3751	8	7	microbial	microbial	ADJ
gs-3751	8	8	diversity	diversity	NOUN
gs-3751	8	9	and	and	CCONJ
gs-3751	8	10	function	function	NOUN
gs-3751	8	11	,	,	PUNCT
gs-3751	8	12	is	be	AUX
gs-3751	8	13	increasingly	increasingly	ADV
gs-3751	8	14	implicated	implicate	VERB
gs-3751	8	15	in	in	ADP
gs-3751	8	16	the	the	DET
gs-3751	8	17	pathogenesis	pathogenesis	NOUN
gs-3751	8	18	of	of	ADP
gs-3751	8	19	neurodegenerative	neurodegenerative	ADJ
gs-3751	8	20	disorders	disorder	NOUN
gs-3751	8	21	,	,	PUNCT
gs-3751	8	22	particularly	particularly	ADV
gs-3751	8	23	alzheimer	alzheimer	X
gs-3751	8	24	’s	’s	PART
gs-3751	8	25	disease	disease	NOUN
gs-3751	8	26	(	(	PUNCT
gs-3751	8	27	ad	ad	NOUN
gs-3751	8	28	)	)	PUNCT
gs-3751	8	29	and	and	CCONJ
gs-3751	8	30	parkinson	parkinson	NOUN
gs-3751	8	31	’s	’s	PART
gs-3751	8	32	disease	disease	NOUN
gs-3751	8	33	(	(	PUNCT
gs-3751	8	34	pd	pd	NOUN
gs-3751	8	35	)	)	PUNCT
gs-3751	8	36	.	.	PUNCT
gs-3751	9	1	in	in	ADP
gs-3751	9	2	ad	ad	NOUN
gs-3751	9	3	,	,	PUNCT
gs-3751	9	4	gut	gut	NOUN
gs-3751	9	5	-	-	PUNCT
gs-3751	9	6	derived	derive	VERB
gs-3751	9	7	metabolites	metabolite	NOUN
gs-3751	9	8	like	like	ADP
gs-3751	9	9	trimethylamine	trimethylamine	NOUN
gs-3751	9	10	n	n	CCONJ
gs-3751	9	11	-	-	PUNCT
gs-3751	9	12	oxide	oxide	NOUN
gs-3751	9	13	(	(	PUNCT
gs-3751	9	14	tmao	tmao	PROPN
gs-3751	9	15	)	)	PUNCT
gs-3751	9	16	and	and	CCONJ
gs-3751	9	17	amyloidogenic	amyloidogenic	ADJ
gs-3751	9	18	proteins	protein	NOUN
gs-3751	9	19	exacerbate	exacerbate	VERB
gs-3751	9	20	neuroinflammation	neuroinflammation	NOUN
gs-3751	9	21	and	and	CCONJ
gs-3751	9	22	amyloid	amyloid	NOUN
gs-3751	9	23	-	-	PUNCT
gs-3751	9	24	beta	beta	NOUN
gs-3751	9	25	aggregation	aggregation	NOUN
gs-3751	9	26	,	,	PUNCT
gs-3751	9	27	while	while	SCONJ
gs-3751	9	28	in	in	ADP
gs-3751	9	29	pd	pd	PROPN
gs-3751	9	30	,	,	PUNCT
gs-3751	9	31	α	α	PROPN
gs-3751	9	32	-	-	PUNCT
gs-3751	9	33	synuclein	synuclein	NOUN
gs-3751	9	34	misfolding	misfolde	VERB
gs-3751	9	35	in	in	ADP
gs-3751	9	36	the	the	DET
gs-3751	9	37	enteric	enteric	ADJ
gs-3751	9	38	nervous	nervous	ADJ
gs-3751	9	39	system	system	NOUN
gs-3751	9	40	precedes	precede	VERB
gs-3751	9	41	motor	motor	NOUN
gs-3751	9	42	symptoms	symptom	NOUN
gs-3751	9	43	,	,	PUNCT
gs-3751	9	44	propagating	propagate	VERB
gs-3751	9	45	pathology	pathology	NOUN
gs-3751	9	46	via	via	ADP
gs-3751	9	47	the	the	DET
gs-3751	9	48	georgian	georgian	ADJ
gs-3751	9	49	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3751	9	50	მეცნიერები	მეცნიერები	NOUN
gs-3751	9	51	ტ.	ტ.	VERB
gs-3751	9	52	7	7	NUM
gs-3751	9	53	n	n	DET
gs-3751	9	54	2	2	NUM
gs-3751	9	55	,	,	PUNCT
gs-3751	9	56	2025	2025	NUM
gs-3751	9	57	330	330	NUM
gs-3751	9	58	vagus	vagus	ADJ
gs-3751	9	59	nerve	nerve	NOUN
gs-3751	9	60	.	.	PUNCT
gs-3751	10	1	emerging	emerge	VERB
gs-3751	10	2	evidence	evidence	NOUN
gs-3751	10	3	underscores	underscore	VERB
gs-3751	10	4	the	the	DET
gs-3751	10	5	microbiome	microbiome	NOUN
gs-3751	10	6	’s	’s	PART
gs-3751	10	7	role	role	NOUN
gs-3751	10	8	in	in	ADP
gs-3751	10	9	disrupting	disrupt	VERB
gs-3751	10	10	blood	blood	NOUN
gs-3751	10	11	-	-	PUNCT
gs-3751	10	12	brain	brain	NOUN
gs-3751	10	13	barrier	barrier	NOUN
gs-3751	10	14	integrity	integrity	NOUN
gs-3751	10	15	and	and	CCONJ
gs-3751	10	16	promoting	promote	VERB
gs-3751	10	17	neurotoxic	neurotoxic	ADJ
gs-3751	10	18	immune	immune	ADJ
gs-3751	10	19	responses	response	NOUN
gs-3751	10	20	.	.	PUNCT
gs-3751	11	1	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-3751	11	2	strategies	strategy	NOUN
gs-3751	11	3	targeting	target	VERB
gs-3751	11	4	the	the	DET
gs-3751	11	5	gba	gba	NOUN
gs-3751	11	6	,	,	PUNCT
gs-3751	11	7	including	include	VERB
gs-3751	11	8	probiotics	probiotic	NOUN
gs-3751	11	9	,	,	PUNCT
gs-3751	11	10	prebiotics	prebiotic	NOUN
gs-3751	11	11	,	,	PUNCT
gs-3751	11	12	fecal	fecal	ADJ
gs-3751	11	13	microbiota	microbiota	NOUN
gs-3751	11	14	transplantation	transplantation	NOUN
gs-3751	11	15	(	(	PUNCT
gs-3751	11	16	fmt	fmt	NOUN
gs-3751	11	17	)	)	PUNCT
gs-3751	11	18	,	,	PUNCT
gs-3751	11	19	and	and	CCONJ
gs-3751	11	20	small	small	ADJ
gs-3751	11	21	-	-	PUNCT
gs-3751	11	22	molecule	molecule	NOUN
gs-3751	11	23	inhibitors	inhibitor	NOUN
gs-3751	11	24	,	,	PUNCT
gs-3751	11	25	demonstrate	demonstrate	VERB
gs-3751	11	26	potential	potential	NOUN
gs-3751	11	27	in	in	ADP
gs-3751	11	28	restoring	restore	VERB
gs-3751	11	29	microbial	microbial	ADJ
gs-3751	11	30	equilibrium	equilibrium	NOUN
gs-3751	11	31	and	and	CCONJ
gs-3751	11	32	mitigating	mitigate	VERB
gs-3751	11	33	neurodegeneration	neurodegeneration	NOUN
gs-3751	11	34	.	.	PUNCT
gs-3751	12	1	clinical	clinical	ADJ
gs-3751	12	2	trials	trial	NOUN
gs-3751	12	3	highlight	highlight	VERB
gs-3751	12	4	the	the	DET
gs-3751	12	5	efficacy	efficacy	NOUN
gs-3751	12	6	of	of	ADP
gs-3751	12	7	lactobacillus	lactobacillus	NOUN
gs-3751	12	8	and	and	CCONJ
gs-3751	12	9	bifidobacterium	bifidobacterium	NOUN
gs-3751	12	10	strains	strain	NOUN
gs-3751	12	11	in	in	ADP
gs-3751	12	12	reducing	reduce	VERB
gs-3751	12	13	cognitive	cognitive	ADJ
gs-3751	12	14	decline	decline	NOUN
gs-3751	12	15	,	,	PUNCT
gs-3751	12	16	while	while	SCONJ
gs-3751	12	17	fmt	fmt	ADJ
gs-3751	12	18	shows	show	NOUN
gs-3751	12	19	promise	promise	VERB
gs-3751	12	20	in	in	ADP
gs-3751	12	21	alleviating	alleviate	VERB
gs-3751	12	22	motor	motor	NOUN
gs-3751	12	23	symptoms	symptom	NOUN
gs-3751	12	24	in	in	ADP
gs-3751	12	25	pd	pd	PROPN
gs-3751	12	26	.	.	PROPN
gs-3751	12	27	challenges	challenge	NOUN
gs-3751	12	28	such	such	ADJ
gs-3751	12	29	as	as	ADP
gs-3751	12	30	microbiome	microbiome	ADJ
gs-3751	12	31	heterogeneity	heterogeneity	NOUN
gs-3751	12	32	,	,	PUNCT
gs-3751	12	33	sex	sex	NOUN
gs-3751	12	34	-	-	PUNCT
gs-3751	12	35	specific	specific	ADJ
gs-3751	12	36	responses	response	NOUN
gs-3751	12	37	,	,	PUNCT
gs-3751	12	38	and	and	CCONJ
gs-3751	12	39	translational	translational	ADJ
gs-3751	12	40	gaps	gap	NOUN
gs-3751	12	41	between	between	ADP
gs-3751	12	42	preclinical	preclinical	ADJ
gs-3751	12	43	models	model	NOUN
gs-3751	12	44	and	and	CCONJ
gs-3751	12	45	human	human	ADJ
gs-3751	12	46	trials	trial	NOUN
gs-3751	12	47	are	be	AUX
gs-3751	12	48	critically	critically	ADV
gs-3751	12	49	evaluated	evaluate	VERB
gs-3751	12	50	.	.	PUNCT
gs-3751	13	1	by	by	ADP
gs-3751	13	2	integrating	integrate	VERB
gs-3751	13	3	advances	advance	NOUN
gs-3751	13	4	in	in	ADP
gs-3751	13	5	multi	multi	ADJ
gs-3751	13	6	-	-	ADJ
gs-3751	13	7	omics	omic	NOUN
gs-3751	13	8	,	,	PUNCT
gs-3751	13	9	artificial	artificial	ADJ
gs-3751	13	10	intelligence	intelligence	NOUN
gs-3751	13	11	,	,	PUNCT
gs-3751	13	12	and	and	CCONJ
gs-3751	13	13	crispr	crispr	NOUN
gs-3751	13	14	-	-	PUNCT
gs-3751	13	15	based	base	VERB
gs-3751	13	16	microbial	microbial	ADJ
gs-3751	13	17	engineering	engineering	NOUN
gs-3751	13	18	,	,	PUNCT
gs-3751	13	19	this	this	DET
gs-3751	13	20	review	review	NOUN
gs-3751	13	21	advocates	advocate	VERB
gs-3751	13	22	for	for	ADP
gs-3751	13	23	personalized	personalized	ADJ
gs-3751	13	24	approaches	approach	NOUN
gs-3751	13	25	to	to	ADP
gs-3751	13	26	harness	harness	NOUN
gs-3751	13	27	the	the	DET
gs-3751	13	28	gba	gba	NOUN
gs-3751	13	29	’s	’s	PART
gs-3751	13	30	therapeutic	therapeutic	ADJ
gs-3751	13	31	potential	potential	NOUN
gs-3751	13	32	.	.	PUNCT
gs-3751	14	1	ultimately	ultimately	ADV
gs-3751	14	2	,	,	PUNCT
gs-3751	14	3	targeting	target	VERB
gs-3751	14	4	the	the	DET
gs-3751	14	5	gut	gut	NOUN
gs-3751	14	6	microbiome	microbiome	NOUN
gs-3751	14	7	offers	offer	VERB
gs-3751	14	8	a	a	DET
gs-3751	14	9	transformative	transformative	ADJ
gs-3751	14	10	paradigm	paradigm	NOUN
gs-3751	14	11	for	for	ADP
gs-3751	14	12	preventing	prevent	VERB
gs-3751	14	13	and	and	CCONJ
gs-3751	14	14	treating	treat	VERB
gs-3751	14	15	neurodegenerative	neurodegenerative	ADJ
gs-3751	14	16	diseases	disease	NOUN
gs-3751	14	17	,	,	PUNCT
gs-3751	14	18	shifting	shift	VERB
gs-3751	14	19	focus	focus	NOUN
gs-3751	14	20	from	from	ADP
gs-3751	14	21	symptomatic	symptomatic	ADJ
gs-3751	14	22	management	management	NOUN
gs-3751	14	23	to	to	ADP
gs-3751	14	24	early	early	ADJ
gs-3751	14	25	intervention	intervention	NOUN
gs-3751	14	26	and	and	CCONJ
gs-3751	14	27	disease	disease	NOUN
gs-3751	14	28	modification	modification	NOUN
gs-3751	14	29	.	.	PUNCT
gs-3751	15	1	keywords	keyword	NOUN
gs-3751	15	2	:	:	PUNCT
gs-3751	15	3	gut	gut	NOUN
gs-3751	15	4	-	-	PUNCT
gs-3751	15	5	brain	brain	NOUN
gs-3751	15	6	axis	axis	NOUN
gs-3751	15	7	,	,	PUNCT
gs-3751	15	8	microbiome	microbiome	ADJ
gs-3751	15	9	,	,	PUNCT
gs-3751	15	10	neurodegenerative	neurodegenerative	ADJ
gs-3751	15	11	disorders	disorder	NOUN
gs-3751	15	12	,	,	PUNCT
gs-3751	15	13	parkinson	parkinson	NOUN
gs-3751	15	14	's	's	PART
gs-3751	15	15	disease	disease	NOUN
gs-3751	15	16	,	,	PUNCT
gs-3751	15	17	alzheimer	alzheimer	PROPN
gs-3751	15	18	's	's	PART
gs-3751	15	19	disease	disease	NOUN
gs-3751	15	20	,	,	PUNCT
gs-3751	15	21	brain	brain	NOUN
gs-3751	15	22	function	function	NOUN
gs-3751	15	23	modulation	modulation	NOUN
gs-3751	15	24	,	,	PUNCT
gs-3751	15	25	neuroinflammation	neuroinflammation	NOUN
gs-3751	15	26	,	,	PUNCT
gs-3751	15	27	pharmacotherapy	pharmacotherapy	NOUN
gs-3751	15	28	.	.	PUNCT
gs-3751	16	1	introduction	introduction	NOUN
gs-3751	16	2	the	the	DET
gs-3751	16	3	intricate	intricate	ADJ
gs-3751	16	4	bidirectional	bidirectional	ADJ
gs-3751	16	5	communication	communication	NOUN
gs-3751	16	6	between	between	ADP
gs-3751	16	7	the	the	DET
gs-3751	16	8	gastrointestinal	gastrointestinal	ADJ
gs-3751	16	9	tract	tract	NOUN
gs-3751	16	10	and	and	CCONJ
gs-3751	16	11	the	the	DET
gs-3751	16	12	central	central	ADJ
gs-3751	16	13	nervous	nervous	ADJ
gs-3751	16	14	system	system	NOUN
gs-3751	16	15	,	,	PUNCT
gs-3751	16	16	termed	term	VERB
gs-3751	16	17	the	the	DET
gs-3751	16	18	gut	gut	NOUN
gs-3751	16	19	-	-	PUNCT
gs-3751	16	20	brain	brain	NOUN
gs-3751	16	21	axis	axis	NOUN
gs-3751	16	22	,	,	PUNCT
gs-3751	16	23	has	have	AUX
gs-3751	16	24	emerged	emerge	VERB
gs-3751	16	25	as	as	ADP
gs-3751	16	26	a	a	DET
gs-3751	16	27	pivotal	pivotal	ADJ
gs-3751	16	28	frontier	frontier	NOUN
gs-3751	16	29	in	in	ADP
gs-3751	16	30	understanding	understand	VERB
gs-3751	16	31	how	how	SCONJ
gs-3751	16	32	the	the	DET
gs-3751	16	33	microbiome	microbiome	NOUN
gs-3751	16	34	influences	influence	VERB
gs-3751	16	35	brain	brain	NOUN
gs-3751	16	36	health	health	NOUN
gs-3751	16	37	and	and	CCONJ
gs-3751	16	38	disease	disease	NOUN
gs-3751	16	39	.	.	PUNCT
gs-3751	17	1	recent	recent	ADJ
gs-3751	17	2	advances	advance	NOUN
gs-3751	17	3	in	in	ADP
gs-3751	17	4	microbiome	microbiome	ADJ
gs-3751	17	5	research	research	NOUN
gs-3751	17	6	have	have	AUX
gs-3751	17	7	revealed	reveal	VERB
gs-3751	17	8	that	that	SCONJ
gs-3751	17	9	gut	gut	NOUN
gs-3751	17	10	microbiota	microbiota	NOUN
gs-3751	17	11	play	play	VERB
gs-3751	17	12	a	a	DET
gs-3751	17	13	critical	critical	ADJ
gs-3751	17	14	role	role	NOUN
gs-3751	17	15	in	in	ADP
gs-3751	17	16	modulating	modulate	VERB
gs-3751	17	17	brain	brain	NOUN
gs-3751	17	18	function	function	NOUN
gs-3751	17	19	,	,	PUNCT
gs-3751	17	20	including	include	VERB
gs-3751	17	21	neurodevelopment	neurodevelopment	ADJ
gs-3751	17	22	,	,	PUNCT
gs-3751	17	23	cognition	cognition	NOUN
gs-3751	17	24	,	,	PUNCT
gs-3751	17	25	and	and	CCONJ
gs-3751	17	26	emotional	emotional	ADJ
gs-3751	17	27	regulation	regulation	NOUN
gs-3751	17	28	,	,	PUNCT
gs-3751	17	29	through	through	ADP
gs-3751	17	30	mechanisms	mechanism	NOUN
gs-3751	17	31	involving	involve	VERB
gs-3751	17	32	neurotransmitters	neurotransmitter	NOUN
gs-3751	17	33	,	,	PUNCT
gs-3751	17	34	short	short	ADJ
gs-3751	17	35	-	-	PUNCT
gs-3751	17	36	chain	chain	NOUN
gs-3751	17	37	fatty	fatty	NOUN
gs-3751	17	38	acids	acid	NOUN
gs-3751	17	39	(	(	PUNCT
gs-3751	17	40	scfas	scfas	NOUN
gs-3751	17	41	)	)	PUNCT
gs-3751	17	42	,	,	PUNCT
gs-3751	17	43	and	and	CCONJ
gs-3751	17	44	immune	immune	NOUN
gs-3751	17	45	-	-	PUNCT
gs-3751	17	46	mediated	mediate	VERB
gs-3751	17	47	pathways	pathway	NOUN
gs-3751	17	48	.	.	PUNCT
gs-3751	18	1	dysregulation	dysregulation	NOUN
gs-3751	18	2	of	of	ADP
gs-3751	18	3	this	this	DET
gs-3751	18	4	axis	axis	NOUN
gs-3751	18	5	,	,	PUNCT
gs-3751	18	6	often	often	ADV
gs-3751	18	7	driven	drive	VERB
gs-3751	18	8	by	by	ADP
gs-3751	18	9	dysbiosis	dysbiosis	NOUN
gs-3751	18	10	(	(	PUNCT
gs-3751	18	11	microbial	microbial	ADJ
gs-3751	18	12	imbalance	imbalance	NOUN
gs-3751	18	13	)	)	PUNCT
gs-3751	18	14	,	,	PUNCT
gs-3751	18	15	has	have	AUX
gs-3751	18	16	been	be	AUX
gs-3751	18	17	implicated	implicate	VERB
gs-3751	18	18	in	in	ADP
gs-3751	18	19	the	the	DET
gs-3751	18	20	pathogenesis	pathogenesis	NOUN
gs-3751	18	21	of	of	ADP
gs-3751	18	22	neurodegenerative	neurodegenerative	ADJ
gs-3751	18	23	disorders	disorder	NOUN
gs-3751	18	24	such	such	ADJ
gs-3751	18	25	as	as	ADP
gs-3751	18	26	parkinson	parkinson	NOUN
gs-3751	18	27	’s	’s	PART
gs-3751	18	28	disease	disease	NOUN
gs-3751	18	29	and	and	CCONJ
gs-3751	18	30	alzheimer	alzheimer	PROPN
gs-3751	18	31	’s	’s	PART
gs-3751	18	32	disease	disease	NOUN
gs-3751	18	33	.	.	PUNCT
gs-3751	19	1	these	these	DET
gs-3751	19	2	conditions	condition	NOUN
gs-3751	19	3	are	be	AUX
gs-3751	19	4	characterized	characterize	VERB
gs-3751	19	5	by	by	ADP
gs-3751	19	6	pathological	pathological	ADJ
gs-3751	19	7	hallmarks	hallmark	NOUN
gs-3751	19	8	like	like	ADP
gs-3751	19	9	alpha	alpha	NOUN
gs-3751	19	10	-	-	PUNCT
gs-3751	19	11	synuclein	synuclein	NOUN
gs-3751	19	12	aggregation	aggregation	NOUN
gs-3751	19	13	,	,	PUNCT
gs-3751	19	14	amyloid	amyloid	NOUN
gs-3751	19	15	-	-	PUNCT
gs-3751	19	16	beta	beta	NOUN
gs-3751	19	17	plaques	plaque	NOUN
gs-3751	19	18	,	,	PUNCT
gs-3751	19	19	and	and	CCONJ
gs-3751	19	20	tau	tau	PROPN
gs-3751	19	21	protein	protein	NOUN
gs-3751	19	22	tangles	tangle	NOUN
gs-3751	19	23	,	,	PUNCT
gs-3751	19	24	which	which	PRON
gs-3751	19	25	may	may	AUX
gs-3751	19	26	be	be	AUX
gs-3751	19	27	exacerbated	exacerbate	VERB
gs-3751	19	28	by	by	ADP
gs-3751	19	29	neuroinflammation	neuroinflammation	NOUN
gs-3751	19	30	and	and	CCONJ
gs-3751	19	31	oxidative	oxidative	ADJ
gs-3751	19	32	stress	stress	NOUN
gs-3751	19	33	linked	link	VERB
gs-3751	19	34	to	to	ADP
gs-3751	19	35	gut	gut	NOUN
gs-3751	19	36	-	-	PUNCT
gs-3751	19	37	derived	derive	VERB
gs-3751	19	38	metabolites	metabolite	NOUN
gs-3751	19	39	.	.	PUNCT
gs-3751	20	1	the	the	DET
gs-3751	20	2	gut	gut	NOUN
gs-3751	20	3	-	-	PUNCT
gs-3751	20	4	brain	brain	NOUN
gs-3751	20	5	axis	axis	NOUN
gs-3751	20	6	has	have	AUX
gs-3751	20	7	been	be	AUX
gs-3751	20	8	studied	study	VERB
gs-3751	20	9	and	and	CCONJ
gs-3751	20	10	is	be	AUX
gs-3751	20	11	evident	evident	ADJ
gs-3751	20	12	to	to	PART
gs-3751	20	13	have	have	VERB
gs-3751	20	14	a	a	DET
gs-3751	20	15	definite	definite	ADJ
gs-3751	20	16	effect	effect	NOUN
gs-3751	20	17	on	on	ADP
gs-3751	20	18	neurodegenerative	neurodegenerative	ADJ
gs-3751	20	19	diseases	disease	NOUN
gs-3751	20	20	such	such	ADJ
gs-3751	20	21	as	as	ADP
gs-3751	20	22	alzheimer	alzheimer	PROPN
gs-3751	20	23	’s	’s	PART
gs-3751	20	24	and	and	CCONJ
gs-3751	20	25	parkinson	parkinson	NOUN
gs-3751	20	26	’s	’s	PART
gs-3751	20	27	and	and	CCONJ
gs-3751	20	28	has	have	AUX
gs-3751	20	29	attracted	attract	VERB
gs-3751	20	30	increasing	increase	VERB
gs-3751	20	31	attention	attention	NOUN
gs-3751	20	32	in	in	ADP
gs-3751	20	33	recent	recent	ADJ
gs-3751	20	34	research	research	NOUN
gs-3751	20	35	.	.	PUNCT
gs-3751	21	1	the	the	DET
gs-3751	21	2	aim	aim	NOUN
gs-3751	21	3	of	of	ADP
gs-3751	21	4	this	this	DET
gs-3751	21	5	systematic	systematic	ADJ
gs-3751	21	6	review	review	NOUN
gs-3751	21	7	is	be	AUX
gs-3751	21	8	to	to	PART
gs-3751	21	9	discuss	discuss	VERB
gs-3751	21	10	whether	whether	SCONJ
gs-3751	21	11	correcting	correct	VERB
gs-3751	21	12	and	and	CCONJ
gs-3751	21	13	adjusting	adjust	VERB
gs-3751	21	14	the	the	DET
gs-3751	21	15	gut	gut	NOUN
gs-3751	21	16	microbiome	microbiome	NOUN
gs-3751	21	17	can	can	AUX
gs-3751	21	18	help	help	VERB
gs-3751	21	19	improve	improve	VERB
gs-3751	21	20	cognitive	cognitive	ADJ
gs-3751	21	21	function	function	NOUN
gs-3751	21	22	or	or	CCONJ
gs-3751	21	23	slow	slow	VERB
gs-3751	21	24	the	the	DET
gs-3751	21	25	progression	progression	NOUN
gs-3751	21	26	of	of	ADP
gs-3751	21	27	neurodegenerative	neurodegenerative	ADJ
gs-3751	21	28	symptoms	symptom	NOUN
gs-3751	21	29	,	,	PUNCT
gs-3751	21	30	or	or	CCONJ
gs-3751	21	31	is	be	AUX
gs-3751	21	32	standard	standard	ADJ
gs-3751	21	33	treatment	treatment	NOUN
gs-3751	21	34	a	a	DET
gs-3751	21	35	better	well	ADJ
gs-3751	21	36	option	option	NOUN
gs-3751	21	37	.	.	PUNCT
gs-3751	22	1	a	a	DET
gs-3751	22	2	standard	standard	ADJ
gs-3751	22	3	approach	approach	NOUN
gs-3751	22	4	(	(	PUNCT
gs-3751	22	5	standard	standard	ADJ
gs-3751	22	6	treatment	treatment	NOUN
gs-3751	22	7	)	)	PUNCT
gs-3751	22	8	for	for	ADP
gs-3751	22	9	these	these	DET
gs-3751	22	10	diseases	disease	NOUN
gs-3751	22	11	,	,	PUNCT
gs-3751	22	12	such	such	ADJ
gs-3751	22	13	as	as	ADP
gs-3751	22	14	levodopa	levodopa	NOUN
gs-3751	22	15	for	for	ADP
gs-3751	22	16	parkinson	parkinson	NOUN
gs-3751	22	17	’s	’s	PART
gs-3751	22	18	and	and	CCONJ
gs-3751	22	19	cholinesterase	cholinesterase	VERB
gs-3751	22	20	inhibitors	inhibitor	NOUN
gs-3751	22	21	for	for	ADP
gs-3751	22	22	alzheimer	alzheimer	PROPN
gs-3751	22	23	’s	’s	PART
gs-3751	22	24	,	,	PUNCT
gs-3751	22	25	have	have	AUX
gs-3751	22	26	been	be	AUX
gs-3751	22	27	well	well	ADV
gs-3751	22	28	known	know	VERB
gs-3751	22	29	to	to	PART
gs-3751	22	30	improve	improve	VERB
gs-3751	22	31	the	the	DET
gs-3751	22	32	effectiveness	effectiveness	NOUN
gs-3751	22	33	positively	positively	ADV
gs-3751	22	34	in	in	ADP
gs-3751	22	35	symptom	symptom	NOUN
gs-3751	22	36	management	management	NOUN
gs-3751	22	37	and	and	CCONJ
gs-3751	22	38	slowing	slow	VERB
gs-3751	22	39	disease	disease	NOUN
gs-3751	22	40	progression	progression	NOUN
gs-3751	22	41	.	.	PUNCT
gs-3751	23	1	on	on	ADP
gs-3751	23	2	the	the	DET
gs-3751	23	3	other	other	ADJ
gs-3751	23	4	hand	hand	NOUN
gs-3751	23	5	of	of	ADP
gs-3751	23	6	the	the	DET
gs-3751	23	7	spectrum	spectrum	NOUN
gs-3751	23	8	,	,	PUNCT
gs-3751	23	9	modulation	modulation	NOUN
gs-3751	23	10	in	in	ADP
gs-3751	23	11	the	the	DET
gs-3751	23	12	gut	gut	NOUN
gs-3751	23	13	microbiome	microbiome	NOUN
gs-3751	23	14	in	in	ADP
gs-3751	23	15	which	which	PRON
gs-3751	23	16	probiotics	probiotic	NOUN
gs-3751	23	17	,	,	PUNCT
gs-3751	23	18	prebiotics	prebiotic	NOUN
gs-3751	23	19	,	,	PUNCT
gs-3751	23	20	lifestyledietary	lifestyledietary	PROPN
gs-3751	23	21	modifications	modification	NOUN
gs-3751	23	22	,	,	PUNCT
gs-3751	23	23	transplantation	transplantation	NOUN
gs-3751	23	24	of	of	ADP
gs-3751	23	25	fecal	fecal	ADJ
gs-3751	23	26	microbiota	microbiota	NOUN
gs-3751	23	27	are	be	AUX
gs-3751	23	28	implemented	implement	VERB
gs-3751	23	29	is	be	AUX
gs-3751	23	30	also	also	ADV
gs-3751	23	31	an	an	DET
gs-3751	23	32	emerging	emerge	VERB
gs-3751	23	33	area	area	NOUN
gs-3751	23	34	of	of	ADP
gs-3751	23	35	study	study	NOUN
gs-3751	23	36	.	.	PUNCT
gs-3751	24	1	addition	addition	NOUN
gs-3751	24	2	of	of	ADP
gs-3751	24	3	these	these	DET
gs-3751	24	4	factors	factor	NOUN
gs-3751	24	5	(	(	PUNCT
gs-3751	24	6	probiotics	probiotic	NOUN
gs-3751	24	7	,	,	PUNCT
gs-3751	24	8	prebiotics	prebiotic	NOUN
gs-3751	24	9	,	,	PUNCT
gs-3751	24	10	lifestyle	lifestyle	NOUN
gs-3751	24	11	-	-	PUNCT
gs-3751	24	12	dietary	dietary	ADJ
gs-3751	24	13	modifications	modification	NOUN
gs-3751	24	14	,	,	PUNCT
gs-3751	24	15	transplantation	transplantation	NOUN
gs-3751	24	16	of	of	ADP
gs-3751	24	17	fecal	fecal	ADJ
gs-3751	24	18	microbiota	microbiota	NOUN
gs-3751	24	19	)	)	PUNCT
gs-3751	24	20	have	have	AUX
gs-3751	24	21	been	be	AUX
gs-3751	24	22	shown	show	VERB
gs-3751	24	23	to	to	PART
gs-3751	24	24	reduce	reduce	VERB
gs-3751	24	25	inflammation	inflammation	NOUN
gs-3751	24	26	and	and	CCONJ
gs-3751	24	27	further	far	ADV
gs-3751	24	28	improve	improve	VERB
gs-3751	24	29	the	the	DET
gs-3751	24	30	balance	balance	NOUN
gs-3751	24	31	of	of	ADP
gs-3751	24	32	neurotransmitters	neurotransmitter	NOUN
gs-3751	24	33	.	.	PUNCT
gs-3751	25	1	although	although	SCONJ
gs-3751	25	2	different	different	ADJ
gs-3751	25	3	communication	communication	NOUN
gs-3751	25	4	routes	route	NOUN
gs-3751	25	5	between	between	ADP
gs-3751	25	6	the	the	DET
gs-3751	25	7	microbiota	microbiota	NOUN
gs-3751	25	8	and	and	CCONJ
gs-3751	25	9	brain	brain	NOUN
gs-3751	25	10	have	have	AUX
gs-3751	25	11	been	be	AUX
gs-3751	25	12	identified	identify	VERB
gs-3751	25	13	,	,	PUNCT
gs-3751	25	14	further	further	ADJ
gs-3751	25	15	studies	study	NOUN
gs-3751	25	16	must	must	AUX
gs-3751	25	17	clarify	clarify	VERB
gs-3751	25	18	all	all	DET
gs-3751	25	19	the	the	DET
gs-3751	25	20	underlying	underlie	VERB
gs-3751	25	21	mechanisms	mechanism	NOUN
gs-3751	25	22	involved	involve	VERB
gs-3751	25	23	.	.	PUNCT
gs-3751	26	1	the	the	DET
gs-3751	26	2	review	review	NOUN
gs-3751	26	3	will	will	AUX
gs-3751	26	4	prove	prove	VERB
gs-3751	26	5	based	base	VERB
gs-3751	26	6	on	on	ADP
gs-3751	26	7	the	the	DET
gs-3751	26	8	available	available	ADJ
gs-3751	26	9	evidence	evidence	NOUN
gs-3751	26	10	on	on	ADP
gs-3751	26	11	the	the	DET
gs-3751	26	12	effectiveness	effectiveness	NOUN
gs-3751	26	13	of	of	ADP
gs-3751	26	14	gut	gut	NOUN
gs-3751	26	15	microbiome	microbiome	ADJ
gs-3751	26	16	interventions	intervention	NOUN
gs-3751	26	17	.	.	PUNCT
gs-3751	27	1	georgian	georgian	ADJ
gs-3751	27	2	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3751	27	3	მეცნიერები	მეცნიერები	NOUN
gs-3751	27	4	ტ.	ტ.	VERB
gs-3751	27	5	7	7	NUM
gs-3751	27	6	n	n	DET
gs-3751	27	7	2	2	NUM
gs-3751	27	8	,	,	PUNCT
gs-3751	27	9	2025	2025	NUM
gs-3751	27	10	331	331	NUM
gs-3751	27	11	while	while	SCONJ
gs-3751	27	12	enough	enough	ADJ
gs-3751	27	13	research	research	NOUN
gs-3751	27	14	has	have	AUX
gs-3751	27	15	been	be	AUX
gs-3751	27	16	done	do	VERB
gs-3751	27	17	on	on	ADP
gs-3751	27	18	standard	standard	ADJ
gs-3751	27	19	treatment	treatment	NOUN
gs-3751	27	20	as	as	SCONJ
gs-3751	27	21	it	it	PRON
gs-3751	27	22	being	be	AUX
gs-3751	27	23	the	the	DET
gs-3751	27	24	most	most	ADV
gs-3751	27	25	reliable	reliable	ADJ
gs-3751	27	26	primary	primary	ADJ
gs-3751	27	27	source	source	NOUN
gs-3751	27	28	for	for	ADP
gs-3751	27	29	managing	manage	VERB
gs-3751	27	30	neurodegenerative	neurodegenerative	ADJ
gs-3751	27	31	diseases	disease	NOUN
gs-3751	27	32	,	,	PUNCT
gs-3751	27	33	studies	study	NOUN
gs-3751	27	34	on	on	ADP
gs-3751	27	35	microbiome	microbiome	ADJ
gs-3751	27	36	changes	change	NOUN
gs-3751	27	37	are	be	AUX
gs-3751	27	38	still	still	ADV
gs-3751	27	39	being	be	AUX
gs-3751	27	40	conducted	conduct	VERB
gs-3751	27	41	for	for	SCONJ
gs-3751	27	42	it	it	PRON
gs-3751	27	43	to	to	PART
gs-3751	27	44	become	become	VERB
gs-3751	27	45	the	the	DET
gs-3751	27	46	primary	primary	ADJ
gs-3751	27	47	source	source	NOUN
gs-3751	27	48	for	for	ADP
gs-3751	27	49	treating	treat	VERB
gs-3751	27	50	the	the	DET
gs-3751	27	51	improvement	improvement	NOUN
gs-3751	27	52	of	of	ADP
gs-3751	27	53	cognitive	cognitive	ADJ
gs-3751	27	54	function	function	NOUN
gs-3751	27	55	and	and	CCONJ
gs-3751	27	56	slowing	slow	VERB
gs-3751	27	57	down	down	ADP
gs-3751	27	58	the	the	DET
gs-3751	27	59	progression	progression	NOUN
gs-3751	27	60	of	of	ADP
gs-3751	27	61	ndds	ndd	NOUN
gs-3751	27	62	but	but	CCONJ
gs-3751	27	63	for	for	ADP
gs-3751	27	64	now	now	ADV
gs-3751	27	65	,	,	PUNCT
gs-3751	27	66	as	as	ADP
gs-3751	27	67	of	of	ADP
gs-3751	27	68	present	present	NOUN
gs-3751	27	69	,	,	PUNCT
gs-3751	27	70	it	it	PRON
gs-3751	27	71	may	may	AUX
gs-3751	27	72	have	have	VERB
gs-3751	27	73	the	the	DET
gs-3751	27	74	ability	ability	NOUN
gs-3751	27	75	to	to	PART
gs-3751	27	76	provide	provide	VERB
gs-3751	27	77	additional	additional	ADJ
gs-3751	27	78	benefits	benefit	NOUN
gs-3751	27	79	and	and	CCONJ
gs-3751	27	80	work	work	NOUN
gs-3751	27	81	complementary	complementary	ADJ
gs-3751	27	82	to	to	ADP
gs-3751	27	83	the	the	DET
gs-3751	27	84	main	main	ADJ
gs-3751	27	85	primary	primary	ADJ
gs-3751	27	86	standard	standard	ADJ
gs-3751	27	87	treatement	treatement	NOUN
gs-3751	27	88	,	,	PUNCT
gs-3751	27	89	further	further	ADJ
gs-3751	27	90	research	research	NOUN
gs-3751	27	91	and	and	CCONJ
gs-3751	27	92	clinical	clinical	ADJ
gs-3751	27	93	studies	study	NOUN
gs-3751	27	94	are	be	AUX
gs-3751	27	95	required	require	VERB
gs-3751	27	96	to	to	PART
gs-3751	27	97	determine	determine	VERB
gs-3751	27	98	its	its	PRON
gs-3751	27	99	long	long	ADJ
gs-3751	27	100	-	-	PUNCT
gs-3751	27	101	term	term	NOUN
gs-3751	27	102	impact	impact	NOUN
gs-3751	27	103	as	as	ADP
gs-3751	27	104	a	a	DET
gs-3751	27	105	primary	primary	ADJ
gs-3751	27	106	source	source	NOUN
gs-3751	27	107	of	of	ADP
gs-3751	27	108	treatment	treatment	NOUN
gs-3751	27	109	and	and	CCONJ
gs-3751	27	110	potential	potential	ADJ
gs-3751	27	111	integration	integration	NOUN
gs-3751	27	112	into	into	ADP
gs-3751	27	113	therapeutic	therapeutic	ADJ
gs-3751	27	114	practice	practice	NOUN
gs-3751	27	115	.	.	PUNCT
gs-3751	28	1	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-3751	28	2	strategies	strategy	NOUN
gs-3751	28	3	targeting	target	VERB
gs-3751	28	4	the	the	DET
gs-3751	28	5	gut	gut	NOUN
gs-3751	28	6	-	-	PUNCT
gs-3751	28	7	brain	brain	NOUN
gs-3751	28	8	axis	axis	NOUN
gs-3751	28	9	,	,	PUNCT
gs-3751	28	10	including	include	VERB
gs-3751	28	11	probiotics	probiotic	NOUN
gs-3751	28	12	,	,	PUNCT
gs-3751	28	13	prebiotics	prebiotic	NOUN
gs-3751	28	14	,	,	PUNCT
gs-3751	28	15	and	and	CCONJ
gs-3751	28	16	fecal	fecal	ADJ
gs-3751	28	17	microbiota	microbiota	NOUN
gs-3751	28	18	transplantation	transplantation	NOUN
gs-3751	28	19	(	(	PUNCT
gs-3751	28	20	fmt	fmt	NOUN
gs-3751	28	21	)	)	PUNCT
gs-3751	28	22	,	,	PUNCT
gs-3751	28	23	are	be	AUX
gs-3751	28	24	gaining	gain	VERB
gs-3751	28	25	traction	traction	NOUN
gs-3751	28	26	as	as	ADP
gs-3751	28	27	potential	potential	ADJ
gs-3751	28	28	avenues	avenue	NOUN
gs-3751	28	29	to	to	PART
gs-3751	28	30	restore	restore	VERB
gs-3751	28	31	microbial	microbial	ADJ
gs-3751	28	32	balance	balance	NOUN
gs-3751	28	33	and	and	CCONJ
gs-3751	28	34	mitigate	mitigate	VERB
gs-3751	28	35	neurodegeneration	neurodegeneration	NOUN
gs-3751	28	36	.	.	PUNCT
gs-3751	29	1	concurrently	concurrently	ADV
gs-3751	29	2	,	,	PUNCT
gs-3751	29	3	novel	novel	ADJ
gs-3751	29	4	neuroactive	neuroactive	ADJ
gs-3751	29	5	compounds	compound	NOUN
gs-3751	29	6	and	and	CCONJ
gs-3751	29	7	personalized	personalized	ADJ
gs-3751	29	8	medicine	medicine	NOUN
gs-3751	29	9	approaches	approach	NOUN
gs-3751	29	10	are	be	AUX
gs-3751	29	11	being	be	AUX
gs-3751	29	12	explored	explore	VERB
gs-3751	29	13	to	to	PART
gs-3751	29	14	enhance	enhance	VERB
gs-3751	29	15	neuroprotection	neuroprotection	NOUN
gs-3751	29	16	and	and	CCONJ
gs-3751	29	17	modulate	modulate	VERB
gs-3751	29	18	the	the	DET
gs-3751	29	19	blood	blood	NOUN
gs-3751	29	20	-	-	PUNCT
gs-3751	29	21	brain	brain	NOUN
gs-3751	29	22	barrier	barrier	NOUN
gs-3751	29	23	permeability	permeability	NOUN
gs-3751	29	24	.	.	PUNCT
gs-3751	30	1	despite	despite	SCONJ
gs-3751	30	2	promising	promise	VERB
gs-3751	30	3	preclinical	preclinical	ADJ
gs-3751	30	4	and	and	CCONJ
gs-3751	30	5	clinical	clinical	ADJ
gs-3751	30	6	trials	trial	NOUN
gs-3751	30	7	data	datum	NOUN
gs-3751	30	8	,	,	PUNCT
gs-3751	30	9	challenges	challenge	NOUN
gs-3751	30	10	remain	remain	VERB
gs-3751	30	11	in	in	ADP
gs-3751	30	12	translating	translate	VERB
gs-3751	30	13	these	these	DET
gs-3751	30	14	findings	finding	NOUN
gs-3751	30	15	into	into	ADP
gs-3751	30	16	safe	safe	ADJ
gs-3751	30	17	,	,	PUNCT
gs-3751	30	18	effective	effective	ADJ
gs-3751	30	19	therapies	therapy	NOUN
gs-3751	30	20	.	.	PUNCT
gs-3751	31	1	this	this	DET
gs-3751	31	2	review	review	NOUN
gs-3751	31	3	synthesizes	synthesize	VERB
gs-3751	31	4	current	current	ADJ
gs-3751	31	5	evidence	evidence	NOUN
gs-3751	31	6	on	on	ADP
gs-3751	31	7	the	the	DET
gs-3751	31	8	microbiome	microbiome	NOUN
gs-3751	31	9	’s	’s	PART
gs-3751	31	10	role	role	NOUN
gs-3751	31	11	in	in	ADP
gs-3751	31	12	brain	brain	NOUN
gs-3751	31	13	disorders	disorder	NOUN
gs-3751	31	14	,	,	PUNCT
gs-3751	31	15	examines	examine	VERB
gs-3751	31	16	emerging	emerge	VERB
gs-3751	31	17	therapeutic	therapeutic	ADJ
gs-3751	31	18	interventions	intervention	NOUN
gs-3751	31	19	,	,	PUNCT
gs-3751	31	20	and	and	CCONJ
gs-3751	31	21	highlights	highlight	VERB
gs-3751	31	22	the	the	DET
gs-3751	31	23	transformative	transformative	ADJ
gs-3751	31	24	potential	potential	NOUN
gs-3751	31	25	of	of	ADP
gs-3751	31	26	drug	drug	NOUN
gs-3751	31	27	development	development	NOUN
gs-3751	31	28	strategies	strategy	NOUN
gs-3751	31	29	rooted	root	VERB
gs-3751	31	30	in	in	ADP
gs-3751	31	31	the	the	DET
gs-3751	31	32	gut	gut	NOUN
gs-3751	31	33	-	-	PUNCT
gs-3751	31	34	brain	brain	NOUN
gs-3751	31	35	axis	axis	NOUN
gs-3751	31	36	for	for	ADP
gs-3751	31	37	combating	combat	VERB
gs-3751	31	38	neurodegenerative	neurodegenerative	ADJ
gs-3751	31	39	diseases	disease	NOUN
gs-3751	31	40	.	.	PUNCT
gs-3751	32	1	the	the	DET
gs-3751	32	2	gut	gut	NOUN
gs-3751	32	3	-	-	PUNCT
gs-3751	32	4	brain	brain	NOUN
gs-3751	32	5	axis	axis	NOUN
gs-3751	32	6	—	—	PUNCT
gs-3751	32	7	a	a	DET
gs-3751	32	8	dynamic	dynamic	ADJ
gs-3751	32	9	network	network	NOUN
gs-3751	32	10	of	of	ADP
gs-3751	32	11	biochemical	biochemical	ADJ
gs-3751	32	12	and	and	CCONJ
gs-3751	32	13	neural	neural	ADJ
gs-3751	32	14	signaling	signal	VERB
gs-3751	32	15	pathways	pathway	NOUN
gs-3751	32	16	connecting	connect	VERB
gs-3751	32	17	the	the	DET
gs-3751	32	18	enteric	enteric	ADJ
gs-3751	32	19	nervous	nervous	ADJ
gs-3751	32	20	system	system	NOUN
gs-3751	32	21	to	to	ADP
gs-3751	32	22	the	the	DET
gs-3751	32	23	central	central	ADJ
gs-3751	32	24	nervous	nervous	ADJ
gs-3751	32	25	system	system	NOUN
gs-3751	32	26	—	—	PUNCT
gs-3751	32	27	has	have	AUX
gs-3751	32	28	revolutionized	revolutionize	VERB
gs-3751	32	29	our	our	PRON
gs-3751	32	30	understanding	understanding	NOUN
gs-3751	32	31	of	of	ADP
gs-3751	32	32	how	how	SCONJ
gs-3751	32	33	peripheral	peripheral	ADJ
gs-3751	32	34	microbial	microbial	ADJ
gs-3751	32	35	communities	community	NOUN
gs-3751	32	36	influence	influence	VERB
gs-3751	32	37	neurological	neurological	ADJ
gs-3751	32	38	health	health	NOUN
gs-3751	32	39	.	.	PUNCT
gs-3751	33	1	at	at	ADP
gs-3751	33	2	the	the	DET
gs-3751	33	3	heart	heart	NOUN
gs-3751	33	4	of	of	ADP
gs-3751	33	5	this	this	DET
gs-3751	33	6	axis	axis	NOUN
gs-3751	33	7	lies	lie	VERB
gs-3751	33	8	the	the	DET
gs-3751	33	9	gut	gut	NOUN
gs-3751	33	10	microbiota	microbiota	NOUN
gs-3751	33	11	,	,	PUNCT
gs-3751	33	12	a	a	DET
gs-3751	33	13	diverse	diverse	ADJ
gs-3751	33	14	ecosystem	ecosystem	NOUN
gs-3751	33	15	of	of	ADP
gs-3751	33	16	trillions	trillion	NOUN
gs-3751	33	17	of	of	ADP
gs-3751	33	18	microorganisms	microorganism	NOUN
gs-3751	33	19	that	that	PRON
gs-3751	33	20	produce	produce	VERB
gs-3751	33	21	metabolites	metabolite	NOUN
gs-3751	33	22	such	such	ADJ
gs-3751	33	23	as	as	ADP
gs-3751	33	24	short	short	ADJ
gs-3751	33	25	-	-	PUNCT
gs-3751	33	26	chain	chain	NOUN
gs-3751	33	27	fatty	fatty	NOUN
gs-3751	33	28	acids	acid	NOUN
gs-3751	33	29	(	(	PUNCT
gs-3751	33	30	scfas	scfas	NOUN
gs-3751	33	31	)	)	PUNCT
gs-3751	33	32	,	,	PUNCT
gs-3751	33	33	neurotransmitters	neurotransmitter	NOUN
gs-3751	33	34	(	(	PUNCT
gs-3751	33	35	e.g.	e.g.	ADV
gs-3751	33	36	,	,	PUNCT
gs-3751	33	37	serotonin	serotonin	NOUN
gs-3751	33	38	,	,	PUNCT
gs-3751	33	39	gaba	gaba	NOUN
gs-3751	33	40	)	)	PUNCT
gs-3751	33	41	,	,	PUNCT
gs-3751	33	42	and	and	CCONJ
gs-3751	33	43	immune	immune	NOUN
gs-3751	33	44	-	-	PUNCT
gs-3751	33	45	modulating	modulate	VERB
gs-3751	33	46	molecules	molecule	NOUN
gs-3751	33	47	.	.	PUNCT
gs-3751	34	1	these	these	DET
gs-3751	34	2	microbial	microbial	ADJ
gs-3751	34	3	products	product	NOUN
gs-3751	34	4	not	not	PART
gs-3751	34	5	only	only	ADV
gs-3751	34	6	regulate	regulate	VERB
gs-3751	34	7	intestinal	intestinal	ADJ
gs-3751	34	8	homeostasis	homeostasis	NOUN
gs-3751	34	9	but	but	CCONJ
gs-3751	34	10	also	also	ADV
gs-3751	34	11	permeate	permeate	VERB
gs-3751	34	12	the	the	DET
gs-3751	34	13	blood	blood	NOUN
gs-3751	34	14	-	-	PUNCT
gs-3751	34	15	brain	brain	NOUN
gs-3751	34	16	barrier	barrier	NOUN
gs-3751	34	17	,	,	PUNCT
gs-3751	34	18	directly	directly	ADV
gs-3751	34	19	or	or	CCONJ
gs-3751	34	20	indirectly	indirectly	ADV
gs-3751	34	21	shaping	shape	VERB
gs-3751	34	22	brain	brain	NOUN
gs-3751	34	23	function	function	NOUN
gs-3751	34	24	,	,	PUNCT
gs-3751	34	25	synaptic	synaptic	ADJ
gs-3751	34	26	plasticity	plasticity	NOUN
gs-3751	34	27	,	,	PUNCT
gs-3751	34	28	and	and	CCONJ
gs-3751	34	29	behavior	behavior	NOUN
gs-3751	34	30	.	.	PUNCT
gs-3751	35	1	emerging	emerge	VERB
gs-3751	35	2	evidence	evidence	NOUN
gs-3751	35	3	underscores	underscore	VERB
gs-3751	35	4	the	the	DET
gs-3751	35	5	microbiome	microbiome	NOUN
gs-3751	35	6	’s	’s	PART
gs-3751	35	7	role	role	NOUN
gs-3751	35	8	in	in	ADP
gs-3751	35	9	both	both	CCONJ
gs-3751	35	10	neuroprotection	neuroprotection	NOUN
gs-3751	35	11	and	and	CCONJ
gs-3751	35	12	neurodegeneration	neurodegeneration	NOUN
gs-3751	35	13	,	,	PUNCT
gs-3751	35	14	with	with	ADP
gs-3751	35	15	dysbiosis	dysbiosis	NOUN
gs-3751	35	16	linked	link	VERB
gs-3751	35	17	to	to	ADP
gs-3751	35	18	chronic	chronic	ADJ
gs-3751	35	19	neuroinflammation	neuroinflammation	NOUN
gs-3751	35	20	,	,	PUNCT
gs-3751	35	21	mitochondrial	mitochondrial	ADJ
gs-3751	35	22	dysfunction	dysfunction	NOUN
gs-3751	35	23	,	,	PUNCT
gs-3751	35	24	and	and	CCONJ
gs-3751	35	25	protein	protein	NOUN
gs-3751	35	26	misfolding	misfolding	NOUN
gs-3751	35	27	—	—	PUNCT
gs-3751	35	28	hallmarks	hallmark	NOUN
gs-3751	35	29	of	of	ADP
gs-3751	35	30	parkinson	parkinson	NOUN
gs-3751	35	31	’s	’s	PART
gs-3751	35	32	disease	disease	NOUN
gs-3751	35	33	(	(	PUNCT
gs-3751	35	34	pd	pd	NOUN
gs-3751	35	35	)	)	PUNCT
gs-3751	35	36	and	and	CCONJ
gs-3751	35	37	alzheimer	alzheimer	PROPN
gs-3751	35	38	’s	’s	PART
gs-3751	35	39	disease	disease	NOUN
gs-3751	35	40	(	(	PUNCT
gs-3751	35	41	ad	ad	NOUN
gs-3751	35	42	)	)	PUNCT
gs-3751	35	43	.	.	PUNCT
gs-3751	36	1	in	in	ADP
gs-3751	36	2	pd	pd	PROPN
gs-3751	36	3	,	,	PUNCT
gs-3751	36	4	gastrointestinal	gastrointestinal	ADJ
gs-3751	36	5	symptoms	symptom	NOUN
gs-3751	36	6	often	often	ADV
gs-3751	36	7	precede	precede	VERB
gs-3751	36	8	motor	motor	NOUN
gs-3751	36	9	deficits	deficit	NOUN
gs-3751	36	10	,	,	PUNCT
gs-3751	36	11	correlating	correlate	VERB
gs-3751	36	12	with	with	ADP
gs-3751	36	13	pathological	pathological	ADJ
gs-3751	36	14	alpha	alpha	NOUN
gs-3751	36	15	-	-	PUNCT
gs-3751	36	16	synuclein	synuclein	NOUN
gs-3751	36	17	aggregation	aggregation	NOUN
gs-3751	36	18	that	that	PRON
gs-3751	36	19	may	may	AUX
gs-3751	36	20	originate	originate	VERB
gs-3751	36	21	in	in	ADP
gs-3751	36	22	the	the	DET
gs-3751	36	23	gut	gut	NOUN
gs-3751	36	24	and	and	CCONJ
gs-3751	36	25	propagate	propagate	VERB
gs-3751	36	26	via	via	ADP
gs-3751	36	27	the	the	DET
gs-3751	36	28	vagus	vagus	NOUN
gs-3751	36	29	nerve	nerve	NOUN
gs-3751	36	30	.	.	PUNCT
gs-3751	37	1	similarly	similarly	ADV
gs-3751	37	2	,	,	PUNCT
gs-3751	37	3	ad	ad	NOUN
gs-3751	37	4	is	be	AUX
gs-3751	37	5	associated	associate	VERB
gs-3751	37	6	with	with	ADP
gs-3751	37	7	altered	altered	ADJ
gs-3751	37	8	gut	gut	NOUN
gs-3751	37	9	microbial	microbial	ADJ
gs-3751	37	10	profiles	profile	NOUN
gs-3751	37	11	that	that	PRON
gs-3751	37	12	exacerbate	exacerbate	VERB
gs-3751	37	13	amyloid	amyloid	NOUN
gs-3751	37	14	-	-	PUNCT
gs-3751	37	15	beta	beta	NOUN
gs-3751	37	16	deposition	deposition	NOUN
gs-3751	37	17	and	and	CCONJ
gs-3751	37	18	tau	tau	PROPN
gs-3751	37	19	protein	protein	NOUN
gs-3751	37	20	hyperphosphorylation	hyperphosphorylation	NOUN
gs-3751	37	21	.	.	PUNCT
gs-3751	38	1	these	these	DET
gs-3751	38	2	findings	finding	NOUN
gs-3751	38	3	position	position	VERB
gs-3751	38	4	the	the	DET
gs-3751	38	5	microbiome	microbiome	NOUN
gs-3751	38	6	as	as	ADP
gs-3751	38	7	a	a	DET
gs-3751	38	8	modifiable	modifiable	ADJ
gs-3751	38	9	risk	risk	NOUN
gs-3751	38	10	factor	factor	NOUN
gs-3751	38	11	and	and	CCONJ
gs-3751	38	12	therapeutic	therapeutic	ADJ
gs-3751	38	13	target	target	NOUN
gs-3751	38	14	.	.	PUNCT
gs-3751	39	1	current	current	ADJ
gs-3751	39	2	pharmacotherapy	pharmacotherapy	NOUN
gs-3751	39	3	strategies	strategy	NOUN
gs-3751	39	4	for	for	ADP
gs-3751	39	5	neurodegeneration	neurodegeneration	NOUN
gs-3751	39	6	,	,	PUNCT
gs-3751	39	7	such	such	ADJ
gs-3751	39	8	as	as	ADP
gs-3751	39	9	dopamine	dopamine	NOUN
gs-3751	39	10	replacement	replacement	NOUN
gs-3751	39	11	in	in	ADP
gs-3751	39	12	pd	pd	PROPN
gs-3751	39	13	or	or	CCONJ
gs-3751	39	14	acetylcholinesterase	acetylcholinesterase	VERB
gs-3751	39	15	inhibitors	inhibitor	NOUN
gs-3751	39	16	in	in	ADP
gs-3751	39	17	ad	ad	NOUN
gs-3751	39	18	,	,	PUNCT
gs-3751	39	19	offer	offer	VERB
gs-3751	39	20	symptomatic	symptomatic	ADJ
gs-3751	39	21	relief	relief	NOUN
gs-3751	39	22	but	but	CCONJ
gs-3751	39	23	fail	fail	VERB
gs-3751	39	24	to	to	PART
gs-3751	39	25	halt	halt	VERB
gs-3751	39	26	disease	disease	NOUN
gs-3751	39	27	progression	progression	NOUN
gs-3751	39	28	.	.	PUNCT
gs-3751	40	1	this	this	PRON
gs-3751	40	2	has	have	AUX
gs-3751	40	3	spurred	spur	VERB
gs-3751	40	4	interest	interest	NOUN
gs-3751	40	5	in	in	ADP
gs-3751	40	6	microbiota	microbiota	ADJ
gs-3751	40	7	-	-	PUNCT
gs-3751	40	8	centric	centric	ADJ
gs-3751	40	9	interventions	intervention	NOUN
gs-3751	40	10	,	,	PUNCT
gs-3751	40	11	including	include	VERB
gs-3751	40	12	probiotics	probiotic	NOUN
gs-3751	40	13	,	,	PUNCT
gs-3751	40	14	psychobiotics	psychobiotic	NOUN
gs-3751	40	15	,	,	PUNCT
gs-3751	40	16	and	and	CCONJ
gs-3751	40	17	fecal	fecal	ADJ
gs-3751	40	18	microbiota	microbiota	NOUN
gs-3751	40	19	transplantation	transplantation	NOUN
gs-3751	40	20	(	(	PUNCT
gs-3751	40	21	fmt	fmt	NOUN
gs-3751	40	22	)	)	PUNCT
gs-3751	40	23	,	,	PUNCT
gs-3751	40	24	which	which	PRON
gs-3751	40	25	aim	aim	VERB
gs-3751	40	26	to	to	PART
gs-3751	40	27	rebalance	rebalance	VERB
gs-3751	40	28	microbial	microbial	ADJ
gs-3751	40	29	communities	community	NOUN
gs-3751	40	30	and	and	CCONJ
gs-3751	40	31	suppress	suppress	VERB
gs-3751	40	32	neurotoxic	neurotoxic	ADJ
gs-3751	40	33	pathways	pathway	NOUN
gs-3751	40	34	.	.	PUNCT
gs-3751	41	1	however	however	ADV
gs-3751	41	2	,	,	PUNCT
gs-3751	41	3	translating	translate	VERB
gs-3751	41	4	these	these	DET
gs-3751	41	5	approaches	approach	NOUN
gs-3751	41	6	into	into	ADP
gs-3751	41	7	clinical	clinical	ADJ
gs-3751	41	8	practice	practice	NOUN
gs-3751	41	9	requires	require	VERB
gs-3751	41	10	addressing	address	VERB
gs-3751	41	11	gaps	gap	NOUN
gs-3751	41	12	in	in	ADP
gs-3751	41	13	our	our	PRON
gs-3751	41	14	understanding	understanding	NOUN
gs-3751	41	15	of	of	ADP
gs-3751	41	16	host	host	NOUN
gs-3751	41	17	-	-	PUNCT
gs-3751	41	18	microbe	microbe	NOUN
gs-3751	41	19	interactions	interaction	NOUN
gs-3751	41	20	,	,	PUNCT
gs-3751	41	21	individualized	individualized	ADJ
gs-3751	41	22	responses	response	NOUN
gs-3751	41	23	,	,	PUNCT
gs-3751	41	24	and	and	CCONJ
gs-3751	41	25	long	long	ADJ
gs-3751	41	26	-	-	PUNCT
gs-3751	41	27	term	term	NOUN
gs-3751	41	28	safety	safety	NOUN
gs-3751	41	29	.	.	PUNCT
gs-3751	42	1	mechanisms	mechanism	NOUN
gs-3751	42	2	linking	link	VERB
gs-3751	42	3	the	the	DET
gs-3751	42	4	microbiome	microbiome	NOUN
gs-3751	42	5	to	to	AUX
gs-3751	42	6	brain	brain	NOUN
gs-3751	42	7	function	function	NOUN
gs-3751	42	8	-	-	PUNCT
gs-3751	42	9	neuroimmune	neuroimmune	NOUN
gs-3751	42	10	crosstalk	crosstalk	NOUN
gs-3751	42	11	:	:	PUNCT
gs-3751	42	12	gut	gut	NOUN
gs-3751	42	13	microbes	microbe	NOUN
gs-3751	42	14	regulate	regulate	VERB
gs-3751	42	15	systemic	systemic	ADJ
gs-3751	42	16	and	and	CCONJ
gs-3751	42	17	central	central	ADJ
gs-3751	42	18	immune	immune	ADJ
gs-3751	42	19	responses	response	NOUN
gs-3751	42	20	by	by	ADP
gs-3751	42	21	modulating	modulate	VERB
gs-3751	42	22	cytokine	cytokine	NOUN
gs-3751	42	23	production	production	NOUN
gs-3751	42	24	(	(	PUNCT
gs-3751	42	25	e.g.	e.g.	ADV
gs-3751	42	26	,	,	PUNCT
gs-3751	42	27	il-6	il-6	NUM
gs-3751	42	28	,	,	PUNCT
gs-3751	42	29	tnf	tnf	PROPN
gs-3751	42	30	-	-	PUNCT
gs-3751	42	31	α	α	NOUN
gs-3751	42	32	)	)	PUNCT
gs-3751	42	33	and	and	CCONJ
gs-3751	42	34	microglial	microglial	ADJ
gs-3751	42	35	activation	activation	NOUN
gs-3751	42	36	.	.	PUNCT
gs-3751	43	1	chronic	chronic	ADJ
gs-3751	43	2	neuroinflammation	neuroinflammation	NOUN
gs-3751	43	3	,	,	PUNCT
gs-3751	43	4	driven	drive	VERB
gs-3751	43	5	by	by	ADP
gs-3751	43	6	georgian	georgian	ADJ
gs-3751	43	7	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3751	43	8	მეცნიერები	მეცნიერები	NOUN
gs-3751	43	9	ტ.	ტ.	VERB
gs-3751	43	10	7	7	NUM
gs-3751	43	11	n	n	DET
gs-3751	43	12	2	2	NUM
gs-3751	43	13	,	,	PUNCT
gs-3751	43	14	2025	2025	NUM
gs-3751	43	15	332	332	NUM
gs-3751	43	16	microbial	microbial	ADJ
gs-3751	43	17	lipopolysaccharides	lipopolysaccharide	NOUN
gs-3751	43	18	(	(	PUNCT
gs-3751	43	19	lps	lps	PROPN
gs-3751	43	20	)	)	PUNCT
gs-3751	43	21	or	or	CCONJ
gs-3751	43	22	impaired	impair	VERB
gs-3751	43	23	gut	gut	NOUN
gs-3751	43	24	barrier	barrier	NOUN
gs-3751	43	25	function	function	NOUN
gs-3751	43	26	(	(	PUNCT
gs-3751	43	27	"	"	PUNCT
gs-3751	43	28	leaky	leaky	ADJ
gs-3751	43	29	gut	gut	NOUN
gs-3751	43	30	"	"	PUNCT
gs-3751	43	31	)	)	PUNCT
gs-3751	43	32	,	,	PUNCT
gs-3751	43	33	accelerates	accelerate	VERB
gs-3751	43	34	neurodegeneration	neurodegeneration	NOUN
gs-3751	43	35	.	.	PUNCT
gs-3751	44	1			VERB
gs-3751	44	2	metabolite	metabolite	NOUN
gs-3751	44	3	-	-	PUNCT
gs-3751	44	4	mediated	mediate	VERB
gs-3751	44	5	signaling	signal	VERB
gs-3751	44	6	:	:	PUNCT
gs-3751	44	7	microbial	microbial	ADJ
gs-3751	44	8	metabolites	metabolite	NOUN
gs-3751	44	9	like	like	ADP
gs-3751	44	10	scfas	scfas	NOUN
gs-3751	44	11	(	(	PUNCT
gs-3751	44	12	butyrate	butyrate	NOUN
gs-3751	44	13	,	,	PUNCT
gs-3751	44	14	acetate	acetate	NOUN
gs-3751	44	15	)	)	PUNCT
gs-3751	44	16	enhance	enhance	VERB
gs-3751	44	17	blood	blood	NOUN
gs-3751	44	18	-	-	PUNCT
gs-3751	44	19	brain	brain	NOUN
gs-3751	44	20	barrier	barrier	NOUN
gs-3751	44	21	integrity	integrity	NOUN
gs-3751	44	22	,	,	PUNCT
gs-3751	44	23	reduce	reduce	VERB
gs-3751	44	24	oxidative	oxidative	ADJ
gs-3751	44	25	stress	stress	NOUN
gs-3751	44	26	,	,	PUNCT
gs-3751	44	27	and	and	CCONJ
gs-3751	44	28	promote	promote	VERB
gs-3751	44	29	neuronal	neuronal	ADJ
gs-3751	44	30	survival	survival	NOUN
gs-3751	44	31	via	via	ADP
gs-3751	44	32	histone	histone	NOUN
gs-3751	44	33	deacetylase	deacetylase	NOUN
gs-3751	44	34	inhibition	inhibition	NOUN
gs-3751	44	35	.	.	PUNCT
gs-3751	45	1	conversely	conversely	ADV
gs-3751	45	2	,	,	PUNCT
gs-3751	45	3	dysbiosis	dysbiosis	NOUN
gs-3751	45	4	-	-	PUNCT
gs-3751	45	5	linked	link	VERB
gs-3751	45	6	metabolites	metabolite	NOUN
gs-3751	45	7	(	(	PUNCT
gs-3751	45	8	e.g.	e.g.	ADV
gs-3751	45	9	,	,	PUNCT
gs-3751	45	10	trimethylamine	trimethylamine	NOUN
gs-3751	45	11	n	n	CCONJ
gs-3751	45	12	-	-	PUNCT
gs-3751	45	13	oxide	oxide	NOUN
gs-3751	45	14	)	)	PUNCT
gs-3751	45	15	may	may	AUX
gs-3751	45	16	amplify	amplify	VERB
gs-3751	45	17	neurotoxicity	neurotoxicity	NOUN
gs-3751	45	18	.	.	PUNCT
gs-3751	46	1			ADJ
gs-3751	46	2	vagal	vagal	ADJ
gs-3751	46	3	and	and	CCONJ
gs-3751	46	4	enteric	enteric	ADJ
gs-3751	46	5	nervous	nervous	ADJ
gs-3751	46	6	system	system	NOUN
gs-3751	46	7	pathways	pathway	NOUN
gs-3751	46	8	:	:	PUNCT
gs-3751	46	9	the	the	DET
gs-3751	46	10	vagus	vagus	NOUN
gs-3751	46	11	nerve	nerve	NOUN
gs-3751	46	12	serves	serve	VERB
gs-3751	46	13	as	as	ADP
gs-3751	46	14	a	a	DET
gs-3751	46	15	direct	direct	ADJ
gs-3751	46	16	conduit	conduit	NOUN
gs-3751	46	17	for	for	ADP
gs-3751	46	18	gut	gut	NOUN
gs-3751	46	19	-	-	PUNCT
gs-3751	46	20	derived	derive	VERB
gs-3751	46	21	signals	signal	NOUN
gs-3751	46	22	to	to	PART
gs-3751	46	23	influence	influence	VERB
gs-3751	46	24	brain	brain	NOUN
gs-3751	46	25	regions	region	NOUN
gs-3751	46	26	involved	involve	VERB
gs-3751	46	27	in	in	ADP
gs-3751	46	28	mood	mood	NOUN
gs-3751	46	29	and	and	CCONJ
gs-3751	46	30	cognition	cognition	NOUN
gs-3751	46	31	.	.	PUNCT
gs-3751	47	1	enteric	enteric	ADJ
gs-3751	47	2	glial	glial	ADJ
gs-3751	47	3	cells	cell	NOUN
gs-3751	47	4	,	,	PUNCT
gs-3751	47	5	akin	akin	ADJ
gs-3751	47	6	to	to	ADP
gs-3751	47	7	astrocytes	astrocyte	NOUN
gs-3751	47	8	,	,	PUNCT
gs-3751	47	9	further	far	ADV
gs-3751	47	10	mediate	mediate	VERB
gs-3751	47	11	gut	gut	NOUN
gs-3751	47	12	-	-	PUNCT
gs-3751	47	13	brain	brain	NOUN
gs-3751	47	14	communication	communication	NOUN
gs-3751	47	15	.	.	PUNCT
gs-3751	48	1			VERB
gs-3751	48	2	protein	protein	NOUN
gs-3751	48	3	misfolding	misfolding	NOUN
gs-3751	48	4	and	and	CCONJ
gs-3751	48	5	propagation	propagation	NOUN
gs-3751	48	6	:	:	PUNCT
gs-3751	48	7	gut	gut	NOUN
gs-3751	48	8	-	-	PUNCT
gs-3751	48	9	derived	derive	VERB
gs-3751	48	10	alpha	alpha	NOUN
gs-3751	48	11	-	-	PUNCT
gs-3751	48	12	synuclein	synuclein	NOUN
gs-3751	48	13	fibrils	fibril	NOUN
gs-3751	48	14	in	in	ADP
gs-3751	48	15	pd	pd	PROPN
gs-3751	48	16	and	and	CCONJ
gs-3751	48	17	amyloidogenic	amyloidogenic	ADJ
gs-3751	48	18	peptides	peptide	NOUN
gs-3751	48	19	in	in	ADP
gs-3751	48	20	ad	ad	NOUN
gs-3751	48	21	may	may	AUX
gs-3751	48	22	exploit	exploit	VERB
gs-3751	48	23	prionlike	prionlike	ADJ
gs-3751	48	24	mechanisms	mechanism	NOUN
gs-3751	48	25	to	to	PART
gs-3751	48	26	spread	spread	VERB
gs-3751	48	27	pathology	pathology	NOUN
gs-3751	48	28	from	from	ADP
gs-3751	48	29	the	the	DET
gs-3751	48	30	gut	gut	NOUN
gs-3751	48	31	to	to	ADP
gs-3751	48	32	the	the	DET
gs-3751	48	33	brain	brain	NOUN
gs-3751	48	34	.	.	PUNCT
gs-3751	49	1			ADJ
gs-3751	49	2	implications	implication	NOUN
gs-3751	49	3	in	in	ADP
gs-3751	49	4	parkinson	parkinson	NOUN
gs-3751	49	5	’s	’s	PART
gs-3751	49	6	and	and	CCONJ
gs-3751	49	7	alzheimer	alzheimer	PROPN
gs-3751	49	8	’s	’s	PART
gs-3751	49	9	disease	disease	NOUN
gs-3751	49	10	parkinson	parkinson	NOUN
gs-3751	49	11	’s	’s	PART
gs-3751	49	12	disease	disease	NOUN
gs-3751	49	13	:	:	PUNCT
gs-3751	49	14	dysbiosis	dysbiosis	NOUN
gs-3751	49	15	in	in	ADP
gs-3751	49	16	pd	pd	PROPN
gs-3751	49	17	patients	patient	NOUN
gs-3751	49	18	correlates	correlate	VERB
gs-3751	49	19	with	with	ADP
gs-3751	49	20	reduced	reduce	VERB
gs-3751	49	21	scfa	scfa	NOUN
gs-3751	49	22	-	-	PUNCT
gs-3751	49	23	producing	produce	VERB
gs-3751	49	24	bacteria	bacteria	NOUN
gs-3751	49	25	(	(	PUNCT
gs-3751	49	26	e.g.	e.g.	ADJ
gs-3751	49	27	,	,	PUNCT
gs-3751	49	28	faecalibacterium	faecalibacterium	NOUN
gs-3751	49	29	)	)	PUNCT
gs-3751	49	30	and	and	CCONJ
gs-3751	49	31	increased	increase	VERB
gs-3751	49	32	pro	pro	ADJ
gs-3751	49	33	-	-	ADJ
gs-3751	49	34	inflammatory	inflammatory	ADJ
gs-3751	49	35	taxa	taxa	NOUN
gs-3751	49	36	(	(	PUNCT
gs-3751	49	37	e.g.	e.g.	ADV
gs-3751	49	38	,	,	PUNCT
gs-3751	49	39	enterobacteriaceae	enterobacteriaceae	PROPN
gs-3751	49	40	)	)	PUNCT
gs-3751	49	41	.	.	PUNCT
gs-3751	50	1	preclinical	preclinical	ADJ
gs-3751	50	2	models	model	NOUN
gs-3751	50	3	show	show	VERB
gs-3751	50	4	fmt	fmt	NOUN
gs-3751	50	5	from	from	ADP
gs-3751	50	6	pd	pd	NOUN
gs-3751	50	7	patients	patient	NOUN
gs-3751	50	8	exacerbates	exacerbate	VERB
gs-3751	50	9	motor	motor	NOUN
gs-3751	50	10	deficits	deficit	NOUN
gs-3751	50	11	,	,	PUNCT
gs-3751	50	12	while	while	SCONJ
gs-3751	50	13	probiotics	probiotic	NOUN
gs-3751	50	14	improve	improve	VERB
gs-3751	50	15	gut	gut	NOUN
gs-3751	50	16	permeability	permeability	NOUN
gs-3751	50	17	and	and	CCONJ
gs-3751	50	18	dopaminergic	dopaminergic	ADJ
gs-3751	50	19	neuron	neuron	NOUN
gs-3751	50	20	survival	survival	NOUN
gs-3751	50	21	.	.	PUNCT
gs-3751	51	1	alzheimer	alzheimer	PROPN
gs-3751	51	2	’s	’s	PART
gs-3751	51	3	disease	disease	NOUN
gs-3751	51	4	:	:	PUNCT
gs-3751	51	5	ad	ad	NOUN
gs-3751	51	6	-	-	PUNCT
gs-3751	51	7	associated	associate	VERB
gs-3751	51	8	microbiota	microbiota	NOUN
gs-3751	51	9	exhibit	exhibit	NOUN
gs-3751	51	10	decreased	decrease	VERB
gs-3751	51	11	diversity	diversity	NOUN
gs-3751	51	12	and	and	CCONJ
gs-3751	51	13	elevated	elevated	ADJ
gs-3751	51	14	populations	population	NOUN
gs-3751	51	15	of	of	ADP
gs-3751	51	16	proinflammatory	proinflammatory	ADJ
gs-3751	51	17	escherichia	escherichia	NOUN
gs-3751	51	18	/	/	SYM
gs-3751	51	19	shigella	shigella	PROPN
gs-3751	51	20	.	.	PUNCT
gs-3751	52	1	scfa	scfa	PROPN
gs-3751	52	2	supplementation	supplementation	NOUN
gs-3751	52	3	in	in	ADP
gs-3751	52	4	rodent	rodent	NOUN
gs-3751	52	5	models	model	NOUN
gs-3751	52	6	reduces	reduce	VERB
gs-3751	52	7	amyloid	amyloid	NOUN
gs-3751	52	8	burden	burden	NOUN
gs-3751	52	9	and	and	CCONJ
gs-3751	52	10	improves	improve	VERB
gs-3751	52	11	cognitive	cognitive	ADJ
gs-3751	52	12	performance	performance	NOUN
gs-3751	52	13	,	,	PUNCT
gs-3751	52	14	highlighting	highlight	VERB
gs-3751	52	15	the	the	DET
gs-3751	52	16	microbiome	microbiome	NOUN
gs-3751	52	17	’s	’s	PART
gs-3751	52	18	role	role	NOUN
gs-3751	52	19	in	in	ADP
gs-3751	52	20	neuroprotection	neuroprotection	NOUN
gs-3751	52	21	.	.	PUNCT
gs-3751	53	1	the	the	DET
gs-3751	53	2	human	human	ADJ
gs-3751	53	3	microbiota	microbiota	NOUN
gs-3751	53	4	is	be	AUX
gs-3751	53	5	now	now	ADV
gs-3751	53	6	understood	understand	VERB
gs-3751	53	7	to	to	PART
gs-3751	53	8	have	have	VERB
gs-3751	53	9	a	a	DET
gs-3751	53	10	crucial	crucial	ADJ
gs-3751	53	11	role	role	NOUN
gs-3751	53	12	in	in	ADP
gs-3751	53	13	the	the	DET
gs-3751	53	14	physiology	physiology	NOUN
gs-3751	53	15	and	and	CCONJ
gs-3751	53	16	pathology	pathology	NOUN
gs-3751	53	17	across	across	ADP
gs-3751	53	18	the	the	DET
gs-3751	53	19	body	body	NOUN
gs-3751	53	20	,	,	PUNCT
gs-3751	53	21	including	include	VERB
gs-3751	53	22	normal	normal	ADJ
gs-3751	53	23	brain	brain	NOUN
gs-3751	53	24	function	function	NOUN
gs-3751	53	25	.	.	PUNCT
gs-3751	54	1	there	there	PRON
gs-3751	54	2	is	be	VERB
gs-3751	54	3	an	an	DET
gs-3751	54	4	emerging	emerge	VERB
gs-3751	54	5	consensus	consensus	NOUN
gs-3751	54	6	from	from	ADP
gs-3751	54	7	various	various	ADJ
gs-3751	54	8	fields	field	NOUN
gs-3751	54	9	that	that	PRON
gs-3751	54	10	are	be	AUX
gs-3751	54	11	driven	drive	VERB
gs-3751	54	12	by	by	ADP
gs-3751	54	13	this	this	DET
gs-3751	54	14	bout	bout	NOUN
gs-3751	54	15	framework	framework	NOUN
gs-3751	54	16	,	,	PUNCT
gs-3751	54	17	from	from	ADP
gs-3751	54	18	this	this	PRON
gs-3751	54	19	exists	exist	VERB
gs-3751	54	20	a	a	DET
gs-3751	54	21	myriad	myriad	ADJ
gs-3751	54	22	potential	potential	NOUN
gs-3751	54	23	of	of	ADP
gs-3751	54	24	pathways	pathway	NOUN
gs-3751	54	25	and	and	CCONJ
gs-3751	54	26	phenotypes	phenotype	NOUN
gs-3751	54	27	through	through	ADP
gs-3751	54	28	which	which	PRON
gs-3751	54	29	the	the	DET
gs-3751	54	30	central	central	ADJ
gs-3751	54	31	nervous	nervous	ADJ
gs-3751	54	32	system	system	NOUN
gs-3751	54	33	(	(	PUNCT
gs-3751	54	34	cns	cns	NOUN
gs-3751	54	35	)	)	PUNCT
gs-3751	54	36	cross	cross	NOUN
gs-3751	54	37	communicates	communicate	NOUN
gs-3751	54	38	with	with	ADP
gs-3751	54	39	the	the	DET
gs-3751	54	40	enteric	enteric	ADJ
gs-3751	54	41	components	component	NOUN
gs-3751	54	42	in	in	ADP
gs-3751	54	43	its	its	PRON
gs-3751	54	44	microbiota	microbiota	NOUN
gs-3751	54	45	-	-	PUNCT
gs-3751	54	46	gut	gut	NOUN
gs-3751	54	47	-	-	PUNCT
gs-3751	54	48	brain	brain	NOUN
gs-3751	54	49	axis	axis	NOUN
gs-3751	54	50	.	.	PUNCT
gs-3751	55	1	this	this	DET
gs-3751	55	2	dynamic	dynamic	ADJ
gs-3751	55	3	interplay	interplay	NOUN
gs-3751	55	4	is	be	AUX
gs-3751	55	5	mediated	mediate	VERB
gs-3751	55	6	by	by	ADP
gs-3751	55	7	integrated	integrate	VERB
gs-3751	55	8	neural	neural	ADJ
gs-3751	55	9	,	,	PUNCT
gs-3751	55	10	immune	immune	ADJ
gs-3751	55	11	,	,	PUNCT
gs-3751	55	12	metabolic	metabolic	NOUN
gs-3751	55	13	,	,	PUNCT
gs-3751	55	14	and	and	CCONJ
gs-3751	55	15	endocrine	endocrine	NOUN
gs-3751	55	16	adaptations	adaptation	NOUN
gs-3751	55	17	collectively	collectively	ADV
gs-3751	55	18	affecting	affect	VERB
gs-3751	55	19	brain	brain	NOUN
gs-3751	55	20	function	function	NOUN
gs-3751	55	21	and	and	CCONJ
gs-3751	55	22	neurological	neurological	ADJ
gs-3751	55	23	resilience	resilience	NOUN
gs-3751	55	24	and	and	CCONJ
gs-3751	55	25	ability	ability	NOUN
gs-3751	55	26	.	.	PUNCT
gs-3751	56	1	this	this	PRON
gs-3751	56	2	is	be	AUX
gs-3751	56	3	particularly	particularly	ADV
gs-3751	56	4	interesting	interesting	ADJ
gs-3751	56	5	for	for	ADP
gs-3751	56	6	the	the	DET
gs-3751	56	7	neurodegenerative	neurodegenerative	ADJ
gs-3751	56	8	field	field	NOUN
gs-3751	56	9	and	and	CCONJ
gs-3751	56	10	parkinson´s	parkinson´	NOUN
gs-3751	56	11	disease	disease	NOUN
gs-3751	56	12	(	(	PUNCT
gs-3751	56	13	pd	pd	NOUN
gs-3751	56	14	)	)	PUNCT
gs-3751	56	15	/alzheimer´s	/alzheimer´s	NOUN
gs-3751	57	1	disease	disease	NOUN
gs-3751	57	2	(	(	PUNCT
gs-3751	57	3	ad	ad	NOUN
gs-3751	57	4	)	)	PUNCT
gs-3751	57	5	.	.	PUNCT
gs-3751	58	1	disorders	disorder	NOUN
gs-3751	58	2	such	such	ADJ
gs-3751	58	3	as	as	ADP
gs-3751	58	4	constipation	constipation	NOUN
gs-3751	58	5	and	and	CCONJ
gs-3751	58	6	dysbiosis	dysbiosis	NOUN
gs-3751	58	7	often	often	ADV
gs-3751	58	8	develop	develop	VERB
gs-3751	58	9	many	many	ADJ
gs-3751	58	10	years	year	NOUN
gs-3751	58	11	before	before	ADP
gs-3751	58	12	the	the	DET
gs-3751	58	13	actual	actual	ADJ
gs-3751	58	14	neurological	neurological	ADJ
gs-3751	58	15	symptoms	symptom	NOUN
gs-3751	58	16	.	.	PUNCT
gs-3751	59	1	this	this	DET
gs-3751	59	2	highlights	highlight	NOUN
gs-3751	59	3	and	and	CCONJ
gs-3751	59	4	emphasizes	emphasize	VERB
gs-3751	59	5	the	the	DET
gs-3751	59	6	importance	importance	NOUN
gs-3751	59	7	of	of	ADP
gs-3751	59	8	gut	gut	NOUN
gs-3751	59	9	health	health	NOUN
gs-3751	59	10	in	in	ADP
gs-3751	59	11	disease	disease	NOUN
gs-3751	59	12	progression	progression	NOUN
gs-3751	59	13	of	of	ADP
gs-3751	59	14	neurodegeneration	neurodegeneration	NOUN
gs-3751	59	15	.	.	PUNCT
gs-3751	60	1	the	the	DET
gs-3751	60	2	ever	ever	ADV
gs-3751	60	3	growing	grow	VERB
gs-3751	60	4	state	state	NOUN
gs-3751	60	5	of	of	ADP
gs-3751	60	6	the	the	DET
gs-3751	60	7	field	field	NOUN
gs-3751	60	8	means	mean	VERB
gs-3751	60	9	that	that	SCONJ
gs-3751	60	10	we	we	PRON
gs-3751	60	11	have	have	AUX
gs-3751	60	12	only	only	ADV
gs-3751	60	13	recently	recently	ADV
gs-3751	60	14	been	be	AUX
gs-3751	60	15	able	able	ADJ
gs-3751	60	16	to	to	PART
gs-3751	60	17	build	build	VERB
gs-3751	60	18	on	on	ADP
gs-3751	60	19	the	the	DET
gs-3751	60	20	quality	quality	NOUN
gs-3751	60	21	of	of	ADP
gs-3751	60	22	preclinical	preclinical	ADJ
gs-3751	60	23	and	and	CCONJ
gs-3751	60	24	clinical	clinical	ADJ
gs-3751	60	25	studies	study	NOUN
gs-3751	60	26	explaining	explain	VERB
gs-3751	60	27	,	,	PUNCT
gs-3751	60	28	in	in	ADP
gs-3751	60	29	more	more	ADJ
gs-3751	60	30	detail	detail	NOUN
gs-3751	60	31	than	than	ADP
gs-3751	60	32	previously	previously	ADV
gs-3751	60	33	possible	possible	ADJ
gs-3751	60	34	how	how	SCONJ
gs-3751	60	35	the	the	DET
gs-3751	60	36	gut	gut	NOUN
gs-3751	60	37	microbiota	microbiota	NOUN
gs-3751	60	38	interacts	interact	VERB
gs-3751	60	39	with	with	ADP
gs-3751	60	40	the	the	DET
gs-3751	60	41	cns	cns	NOUN
gs-3751	60	42	.	.	PUNCT
gs-3751	61	1	the	the	DET
gs-3751	61	2	studies	study	NOUN
gs-3751	61	3	performed	perform	VERB
gs-3751	61	4	in	in	ADP
gs-3751	61	5	these	these	DET
gs-3751	61	6	areas	area	NOUN
gs-3751	61	7	have	have	AUX
gs-3751	61	8	shed	shed	VERB
gs-3751	61	9	light	light	NOUN
gs-3751	61	10	into	into	ADP
gs-3751	61	11	the	the	DET
gs-3751	61	12	possible	possible	ADJ
gs-3751	61	13	pathways	pathway	NOUN
gs-3751	61	14	adopted	adopt	VERB
gs-3751	61	15	by	by	ADP
gs-3751	61	16	gm	gm	PROPN
gs-3751	61	17	in	in	ADP
gs-3751	61	18	controlling	control	VERB
gs-3751	61	19	neuro	neuro	PROPN
gs-3751	61	20	inflammation	inflammation	NOUN
gs-3751	61	21	,	,	PUNCT
gs-3751	61	22	amyloid	amyloid	NOUN
gs-3751	61	23	genesis	genesis	NOUN
gs-3751	61	24	(	(	PUNCT
gs-3751	61	25	ag	ag	PROPN
gs-3751	61	26	)	)	PUNCT
gs-3751	61	27	,	,	PUNCT
gs-3751	61	28	oxidative	oxidative	ADJ
gs-3751	61	29	stress	stress	NOUN
gs-3751	61	30	and	and	CCONJ
gs-3751	61	31	neuronal	neuronal	ADJ
gs-3751	61	32	signaling	signal	VERB
gs-3751	61	33	cascades	cascade	NOUN
gs-3751	61	34	during	during	ADP
gs-3751	61	35	the	the	DET
gs-3751	61	36	pathogenic	pathogenic	ADJ
gs-3751	61	37	cycle	cycle	NOUN
gs-3751	61	38	of	of	ADP
gs-3751	61	39	pd/	pd/	ADV
gs-3751	61	40	ad	ad	NOUN
gs-3751	61	41	as	as	SCONJ
gs-3751	61	42	summarized	summarize	VERB
gs-3751	61	43	in	in	ADP
gs-3751	61	44	table	table	NOUN
gs-3751	61	45	1	1	NUM
gs-3751	61	46	.	.	PUNCT
gs-3751	61	47	additionally	additionally	ADV
gs-3751	61	48	,	,	PUNCT
gs-3751	61	49	recent	recent	ADJ
gs-3751	61	50	findings	finding	NOUN
gs-3751	61	51	reveal	reveal	VERB
gs-3751	61	52	that	that	SCONJ
gs-3751	61	53	gut	gut	NOUN
gs-3751	61	54	microbiota	microbiota	NOUN
gs-3751	61	55	changes	change	NOUN
gs-3751	61	56	should	should	AUX
gs-3751	61	57	not	not	PART
gs-3751	61	58	only	only	ADV
gs-3751	61	59	be	be	AUX
gs-3751	61	60	used	use	VERB
gs-3751	61	61	as	as	ADP
gs-3751	61	62	indicators	indicator	NOUN
gs-3751	61	63	of	of	ADP
gs-3751	61	64	early	early	ADJ
gs-3751	61	65	-	-	PUNCT
gs-3751	61	66	stage	stage	NOUN
gs-3751	61	67	diagnosis	diagnosis	NOUN
gs-3751	61	68	but	but	CCONJ
gs-3751	61	69	may	may	AUX
gs-3751	61	70	also	also	ADV
gs-3751	61	71	represent	represent	VERB
gs-3751	61	72	a	a	DET
gs-3751	61	73	therapeutic	therapeutic	ADJ
gs-3751	61	74	approach	approach	NOUN
gs-3751	61	75	which	which	PRON
gs-3751	61	76	provides	provide	VERB
gs-3751	61	77	new	new	ADJ
gs-3751	61	78	georgian	georgian	ADJ
gs-3751	61	79	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3751	61	80	მეცნიერები	მეცნიერები	NOUN
gs-3751	61	81	ტ.	ტ.	VERB
gs-3751	61	82	7	7	NUM
gs-3751	61	83	n	n	DET
gs-3751	61	84	2	2	NUM
gs-3751	61	85	,	,	PUNCT
gs-3751	61	86	2025	2025	NUM
gs-3751	61	87	333	333	NUM
gs-3751	61	88	prospects	prospect	NOUN
gs-3751	61	89	for	for	ADP
gs-3751	61	90	intervention	intervention	NOUN
gs-3751	61	91	.	.	PUNCT
gs-3751	62	1	the	the	DET
gs-3751	62	2	introductory	introductory	ADJ
gs-3751	62	3	role	role	NOUN
gs-3751	62	4	played	play	VERB
gs-3751	62	5	by	by	ADP
gs-3751	62	6	high	high	ADJ
gs-3751	62	7	-	-	PUNCT
gs-3751	62	8	throughput	throughput	NOUN
gs-3751	62	9	sequencing	sequence	VERB
gs-3751	62	10	technologies	technology	NOUN
gs-3751	62	11	in	in	ADP
gs-3751	62	12	profiling	profile	VERB
gs-3751	62	13	microbial	microbial	ADJ
gs-3751	62	14	communities	community	NOUN
gs-3751	62	15	and	and	CCONJ
gs-3751	62	16	characterizing	characterize	VERB
gs-3751	62	17	the	the	DET
gs-3751	62	18	biochemical	biochemical	ADJ
gs-3751	62	19	processes	process	NOUN
gs-3751	62	20	they	they	PRON
gs-3751	62	21	mediate	mediate	VERB
gs-3751	62	22	has	have	AUX
gs-3751	62	23	been	be	AUX
gs-3751	62	24	an	an	DET
gs-3751	62	25	instrumental	instrumental	ADJ
gs-3751	62	26	entry	entry	NOUN
gs-3751	62	27	point	point	NOUN
gs-3751	62	28	for	for	ADP
gs-3751	62	29	unprecedented	unprecedented	ADJ
gs-3751	62	30	virtues	virtue	NOUN
gs-3751	62	31	of	of	ADP
gs-3751	62	32	microbiota	microbiota	NOUN
gs-3751	62	33	-	-	PUNCT
gs-3751	62	34	gut	gut	NOUN
gs-3751	62	35	-	-	PUNCT
gs-3751	62	36	brain	brain	NOUN
gs-3751	62	37	research	research	NOUN
gs-3751	62	38	;	;	PUNCT
gs-3751	62	39	the	the	DET
gs-3751	62	40	complete	complete	ADJ
gs-3751	62	41	unfolding	unfolding	NOUN
gs-3751	62	42	requires	require	VERB
gs-3751	62	43	a	a	DET
gs-3751	62	44	correspondingly	correspondingly	ADV
gs-3751	62	45	unbroken	unbroken	ADJ
gs-3751	62	46	integration	integration	NOUN
gs-3751	62	47	.	.	PUNCT
gs-3751	63	1	microbial	microbial	ADJ
gs-3751	63	2	signatures	signature	NOUN
gs-3751	63	3	have	have	AUX
gs-3751	63	4	been	be	AUX
gs-3751	63	5	related	relate	VERB
gs-3751	63	6	to	to	ADP
gs-3751	63	7	both	both	CCONJ
gs-3751	63	8	dopaminergic	dopaminergic	ADJ
gs-3751	63	9	neuronal	neuronal	ADJ
gs-3751	63	10	degeneration	degeneration	NOUN
gs-3751	63	11	as	as	ADV
gs-3751	63	12	well	well	ADV
gs-3751	63	13	as	as	ADP
gs-3751	63	14	motor	motor	NOUN
gs-3751	63	15	and	and	CCONJ
gs-3751	63	16	non	non	ADJ
gs-3751	63	17	-	-	ADJ
gs-3751	63	18	motor	motor	ADJ
gs-3751	63	19	symptoms	symptom	NOUN
gs-3751	63	20	in	in	ADP
gs-3751	63	21	pd	pd	PROPN
gs-3751	63	22	.	.	PUNCT
gs-3751	64	1	the	the	DET
gs-3751	64	2	same	same	ADJ
gs-3751	64	3	applies	apply	VERB
gs-3751	64	4	in	in	ADP
gs-3751	64	5	ad	ad	NOUN
gs-3751	64	6	,	,	PUNCT
gs-3751	64	7	where	where	SCONJ
gs-3751	64	8	dysbiosis	dysbiosis	NOUN
gs-3751	64	9	amplifies	amplify	VERB
gs-3751	64	10	amyloid	amyloid	NOUN
gs-3751	64	11	-	-	PUNCT
gs-3751	64	12	β	β	X
gs-3751	64	13	and	and	CCONJ
gs-3751	64	14	tau	tau	PROPN
gs-3751	64	15	pathology	pathology	NOUN
gs-3751	64	16	hallmarks	hallmark	NOUN
gs-3751	64	17	of	of	ADP
gs-3751	64	18	the	the	DET
gs-3751	64	19	disease	disease	NOUN
gs-3751	64	20	.	.	PUNCT
gs-3751	65	1	the	the	DET
gs-3751	65	2	current	current	ADJ
gs-3751	65	3	findings	finding	NOUN
gs-3751	65	4	highlight	highlight	VERB
gs-3751	65	5	the	the	DET
gs-3751	65	6	complex	complex	ADJ
gs-3751	65	7	interplay	interplay	NOUN
gs-3751	65	8	of	of	ADP
gs-3751	65	9	gut	gut	NOUN
gs-3751	65	10	microbiome	microbiome	ADJ
gs-3751	65	11	contributions	contribution	NOUN
gs-3751	65	12	to	to	ADP
gs-3751	65	13	disease	disease	NOUN
gs-3751	65	14	pathogenesis	pathogenesis	NOUN
gs-3751	65	15	and	and	CCONJ
gs-3751	65	16	studies	study	NOUN
gs-3751	65	17	reveal	reveal	VERB
gs-3751	65	18	that	that	SCONJ
gs-3751	65	19	it	it	PRON
gs-3751	65	20	will	will	AUX
gs-3751	65	21	ultimately	ultimately	ADV
gs-3751	65	22	be	be	AUX
gs-3751	65	23	necessary	necessary	ADJ
gs-3751	65	24	to	to	PART
gs-3751	65	25	conduct	conduct	VERB
gs-3751	65	26	a	a	DET
gs-3751	65	27	comprehensive	comprehensive	ADJ
gs-3751	65	28	analysis	analysis	NOUN
gs-3751	65	29	applied	apply	VERB
gs-3751	65	30	early	early	ADV
gs-3751	65	31	in	in	ADP
gs-3751	65	32	the	the	DET
gs-3751	65	33	time	time	NOUN
gs-3751	65	34	course	course	NOUN
gs-3751	65	35	given	give	VERB
gs-3751	65	36	where	where	SCONJ
gs-3751	65	37	therapeutic	therapeutic	ADJ
gs-3751	65	38	interventions	intervention	NOUN
gs-3751	65	39	may	may	AUX
gs-3751	65	40	harness	harness	NOUN
gs-3751	65	41	alterations	alteration	NOUN
gs-3751	65	42	at	at	ADP
gs-3751	65	43	the	the	DET
gs-3751	65	44	highest	high	ADJ
gs-3751	65	45	impact	impact	NOUN
gs-3751	65	46	.	.	PUNCT
gs-3751	66	1	we	we	PRON
gs-3751	66	2	intend	intend	VERB
gs-3751	66	3	to	to	PART
gs-3751	66	4	provide	provide	VERB
gs-3751	66	5	concise	concise	ADJ
gs-3751	66	6	overviews	overview	NOUN
gs-3751	66	7	of	of	ADP
gs-3751	66	8	emerging	emerge	VERB
gs-3751	66	9	developing	develop	VERB
gs-3751	66	10	concepts	concept	NOUN
gs-3751	66	11	in	in	ADP
gs-3751	66	12	relation	relation	NOUN
gs-3751	66	13	to	to	ADP
gs-3751	66	14	the	the	DET
gs-3751	66	15	microbiota	microbiota	NOUN
gs-3751	66	16	-	-	PUNCT
gs-3751	66	17	gut	gut	NOUN
gs-3751	66	18	-	-	PUNCT
gs-3751	66	19	brain	brain	NOUN
gs-3751	66	20	axis	axis	NOUN
gs-3751	66	21	as	as	ADP
gs-3751	66	22	they	they	PRON
gs-3751	66	23	directly	directly	ADV
gs-3751	66	24	,	,	PUNCT
gs-3751	66	25	but	but	CCONJ
gs-3751	66	26	not	not	PART
gs-3751	66	27	exclusively	exclusively	ADV
gs-3751	66	28	link	link	VERB
gs-3751	66	29	to	to	ADP
gs-3751	66	30	neurodegenerative	neurodegenerative	ADJ
gs-3751	66	31	diseases	disease	NOUN
gs-3751	66	32	including	include	VERB
gs-3751	66	33	ad	ad	NOUN
gs-3751	66	34	and	and	CCONJ
gs-3751	66	35	pd	pd	PROPN
gs-3751	66	36	.	.	PUNCT
gs-3751	67	1	this	this	DET
gs-3751	67	2	integrated	integrate	VERB
gs-3751	67	3	review	review	NOUN
gs-3751	67	4	describes	describe	VERB
gs-3751	67	5	and	and	CCONJ
gs-3751	67	6	explains	explain	VERB
gs-3751	67	7	the	the	DET
gs-3751	67	8	current	current	ADJ
gs-3751	67	9	knowledge	knowledge	NOUN
gs-3751	67	10	regarding	regard	VERB
gs-3751	67	11	the	the	DET
gs-3751	67	12	contribution	contribution	NOUN
gs-3751	67	13	of	of	ADP
gs-3751	67	14	microbes	microbe	NOUN
gs-3751	67	15	to	to	ADP
gs-3751	67	16	neurological	neurological	ADJ
gs-3751	67	17	health	health	NOUN
gs-3751	67	18	,	,	PUNCT
gs-3751	67	19	expands	expand	VERB
gs-3751	67	20	upon	upon	SCONJ
gs-3751	67	21	proposed	propose	VERB
gs-3751	67	22	mechanistic	mechanistic	ADJ
gs-3751	67	23	insights	insight	NOUN
gs-3751	67	24	,	,	PUNCT
gs-3751	67	25	reveals	reveal	VERB
gs-3751	67	26	opportunities	opportunity	NOUN
gs-3751	67	27	for	for	ADP
gs-3751	67	28	novel	novel	ADJ
gs-3751	67	29	biomarker	biomarker	NOUN
gs-3751	67	30	discovery	discovery	NOUN
gs-3751	67	31	and	and	CCONJ
gs-3751	67	32	discusses	discuss	VERB
gs-3751	67	33	emerging	emerge	VERB
gs-3751	67	34	therapeutic	therapeutic	ADJ
gs-3751	67	35	implications	implication	NOUN
gs-3751	67	36	.	.	PUNCT
gs-3751	68	1	we	we	PRON
gs-3751	68	2	thus	thus	ADV
gs-3751	68	3	hope	hope	VERB
gs-3751	68	4	that	that	SCONJ
gs-3751	68	5	our	our	PRON
gs-3751	68	6	efforts	effort	NOUN
gs-3751	68	7	will	will	AUX
gs-3751	68	8	contribute	contribute	VERB
gs-3751	68	9	to	to	ADP
gs-3751	68	10	a	a	DET
gs-3751	68	11	more	more	ADV
gs-3751	68	12	comprehensive	comprehensive	ADJ
gs-3751	68	13	understanding	understanding	NOUN
gs-3751	68	14	of	of	ADP
gs-3751	68	15	how	how	SCONJ
gs-3751	68	16	the	the	DET
gs-3751	68	17	gut	gut	NOUN
gs-3751	68	18	microflora	microflora	NOUN
gs-3751	68	19	might	might	AUX
gs-3751	68	20	modulate	modulate	VERB
gs-3751	68	21	neurodegenerative	neurodegenerative	ADJ
gs-3751	68	22	disease	disease	NOUN
gs-3751	68	23	progression	progression	NOUN
gs-3751	68	24	,	,	PUNCT
gs-3751	68	25	and	and	CCONJ
gs-3751	68	26	accordingly	accordingly	ADV
gs-3751	68	27	guide	guide	VERB
gs-3751	68	28	novel	novel	ADJ
gs-3751	68	29	preventive	preventive	ADJ
gs-3751	68	30	or	or	CCONJ
gs-3751	68	31	therapeutic	therapeutic	ADJ
gs-3751	68	32	approaches	approach	NOUN
gs-3751	68	33	.	.	PUNCT
gs-3751	69	1			VERB
gs-3751	69	2	pharmacotherapy	pharmacotherapy	NOUN
gs-3751	69	3	and	and	CCONJ
gs-3751	69	4	emerging	emerge	VERB
gs-3751	69	5	strategies	strategy	NOUN
gs-3751	69	6	microbiota	microbiota	NOUN
gs-3751	69	7	-	-	PUNCT
gs-3751	69	8	targeted	target	VERB
gs-3751	69	9	therapies	therapy	NOUN
gs-3751	69	10	:	:	PUNCT
gs-3751	69	11	probiotics	probiotic	NOUN
gs-3751	69	12	/	/	SYM
gs-3751	69	13	prebiotics	prebiotic	NOUN
gs-3751	69	14	:	:	PUNCT
gs-3751	69	15	strains	strain	NOUN
gs-3751	69	16	like	like	ADP
gs-3751	69	17	lactobacillus	lactobacillus	NOUN
gs-3751	69	18	and	and	CCONJ
gs-3751	69	19	bifidobacterium	bifidobacterium	NOUN
gs-3751	69	20	modulate	modulate	VERB
gs-3751	69	21	serotonin	serotonin	NOUN
gs-3751	69	22	synthesis	synthesis	NOUN
gs-3751	69	23	and	and	CCONJ
gs-3751	69	24	reduce	reduce	VERB
gs-3751	69	25	neuroinflammation	neuroinflammation	NOUN
gs-3751	69	26	.	.	PUNCT
gs-3751	70	1	fmt	fmt	PROPN
gs-3751	70	2	:	:	PUNCT
gs-3751	70	3	early	early	ADJ
gs-3751	70	4	-	-	PUNCT
gs-3751	70	5	phase	phase	NOUN
gs-3751	70	6	trials	trial	NOUN
gs-3751	70	7	show	show	VERB
gs-3751	70	8	fmt	fmt	NOUN
gs-3751	70	9	’s	’s	PART
gs-3751	70	10	potential	potential	NOUN
gs-3751	70	11	to	to	PART
gs-3751	70	12	restore	restore	VERB
gs-3751	70	13	microbial	microbial	ADJ
gs-3751	70	14	diversity	diversity	NOUN
gs-3751	70	15	and	and	CCONJ
gs-3751	70	16	ameliorate	ameliorate	VERB
gs-3751	70	17	pd	pd	NOUN
gs-3751	70	18	symptoms	symptom	NOUN
gs-3751	70	19	.	.	PUNCT
gs-3751	71	1	postbiotics	postbiotic	NOUN
gs-3751	71	2	:	:	PUNCT
gs-3751	71	3	purified	purify	VERB
gs-3751	71	4	microbial	microbial	ADJ
gs-3751	71	5	metabolites	metabolite	NOUN
gs-3751	71	6	(	(	PUNCT
gs-3751	71	7	e.g.	e.g.	ADV
gs-3751	71	8	,	,	PUNCT
gs-3751	71	9	butyrate	butyrate	NOUN
gs-3751	71	10	)	)	PUNCT
gs-3751	71	11	bypass	bypass	NOUN
gs-3751	71	12	risks	risk	NOUN
gs-3751	71	13	of	of	ADP
gs-3751	71	14	live	live	ADJ
gs-3751	71	15	organism	organism	NOUN
gs-3751	71	16	administration	administration	NOUN
gs-3751	71	17	.	.	PUNCT
gs-3751	72	1	drug	drug	NOUN
gs-3751	72	2	development	development	NOUN
gs-3751	72	3	challenges	challenge	NOUN
gs-3751	72	4	:	:	PUNCT
gs-3751	72	5	heterogeneity	heterogeneity	NOUN
gs-3751	72	6	in	in	ADP
gs-3751	72	7	human	human	PROPN
gs-3751	72	8	microbiomes	microbiomes	PROPN
gs-3751	72	9	complicates	complicate	VERB
gs-3751	72	10	standardized	standardized	ADJ
gs-3751	72	11	treatments	treatment	NOUN
gs-3751	72	12	.	.	PUNCT
gs-3751	73	1	personalized	personalize	VERB
gs-3751	73	2	medicine	medicine	NOUN
gs-3751	73	3	approaches	approach	NOUN
gs-3751	73	4	,	,	PUNCT
gs-3751	73	5	leveraging	leverage	VERB
gs-3751	73	6	metabolomics	metabolomic	NOUN
gs-3751	73	7	and	and	CCONJ
gs-3751	73	8	ai	ai	ADJ
gs-3751	73	9	-	-	PUNCT
gs-3751	73	10	driven	drive	VERB
gs-3751	73	11	microbiome	microbiome	NOUN
gs-3751	73	12	analysis	analysis	NOUN
gs-3751	73	13	,	,	PUNCT
gs-3751	73	14	may	may	AUX
gs-3751	73	15	optimize	optimize	VERB
gs-3751	73	16	therapeutic	therapeutic	ADJ
gs-3751	73	17	outcomes	outcome	NOUN
gs-3751	73	18	.	.	PUNCT
gs-3751	74	1	blood	blood	NOUN
gs-3751	74	2	-	-	PUNCT
gs-3751	74	3	brain	brain	NOUN
gs-3751	74	4	barrier	barrier	NOUN
gs-3751	74	5	penetration	penetration	NOUN
gs-3751	74	6	:	:	PUNCT
gs-3751	74	7	designing	design	VERB
gs-3751	74	8	neuroactive	neuroactive	ADJ
gs-3751	74	9	compounds	compound	NOUN
gs-3751	74	10	that	that	PRON
gs-3751	74	11	mimic	mimic	VERB
gs-3751	74	12	microbial	microbial	ADJ
gs-3751	74	13	metabolites	metabolite	NOUN
gs-3751	74	14	(	(	PUNCT
gs-3751	74	15	e.g.	e.g.	ADV
gs-3751	74	16	,	,	PUNCT
gs-3751	74	17	scfa	scfa	ADJ
gs-3751	74	18	derivatives	derivative	NOUN
gs-3751	74	19	)	)	PUNCT
gs-3751	74	20	or	or	CCONJ
gs-3751	74	21	enhance	enhance	VERB
gs-3751	74	22	bbb	bbb	PROPN
gs-3751	74	23	transport	transport	NOUN
gs-3751	74	24	is	be	AUX
gs-3751	74	25	a	a	DET
gs-3751	74	26	priority	priority	NOUN
gs-3751	74	27	.	.	PUNCT
gs-3751	75	1	while	while	SCONJ
gs-3751	75	2	the	the	DET
gs-3751	75	3	gut	gut	NOUN
gs-3751	75	4	-	-	PUNCT
gs-3751	75	5	brain	brain	NOUN
gs-3751	75	6	axis	axis	NOUN
gs-3751	75	7	offers	offer	VERB
gs-3751	75	8	unprecedented	unprecedented	ADJ
gs-3751	75	9	opportunities	opportunity	NOUN
gs-3751	75	10	for	for	ADP
gs-3751	75	11	treating	treat	VERB
gs-3751	75	12	neurodegeneration	neurodegeneration	NOUN
gs-3751	75	13	,	,	PUNCT
gs-3751	75	14	key	key	ADJ
gs-3751	75	15	questions	question	NOUN
gs-3751	75	16	remain	remain	VERB
gs-3751	75	17	:	:	PUNCT
gs-3751	75	18	can	can	AUX
gs-3751	75	19	microbiome	microbiome	ADJ
gs-3751	75	20	modulation	modulation	NOUN
gs-3751	75	21	prevent	prevent	NOUN
gs-3751	75	22	disease	disease	NOUN
gs-3751	75	23	onset	onset	VERB
gs-3751	75	24	in	in	ADP
gs-3751	75	25	high	high	ADJ
gs-3751	75	26	-	-	PUNCT
gs-3751	75	27	risk	risk	NOUN
gs-3751	75	28	populations	population	NOUN
gs-3751	75	29	?	?	PUNCT
gs-3751	76	1	how	how	SCONJ
gs-3751	76	2	do	do	AUX
gs-3751	76	3	diet	diet	NOUN
gs-3751	76	4	,	,	PUNCT
gs-3751	76	5	antibiotics	antibiotic	NOUN
gs-3751	76	6	,	,	PUNCT
gs-3751	76	7	and	and	CCONJ
gs-3751	76	8	lifestyle	lifestyle	NOUN
gs-3751	76	9	intersect	intersect	ADJ
gs-3751	76	10	with	with	ADP
gs-3751	76	11	microbial	microbial	ADJ
gs-3751	76	12	therapies	therapy	NOUN
gs-3751	76	13	?	?	PUNCT
gs-3751	77	1	multidisciplinary	multidisciplinary	ADJ
gs-3751	77	2	collaborations	collaboration	NOUN
gs-3751	77	3	integrating	integrate	VERB
gs-3751	77	4	clinical	clinical	ADJ
gs-3751	77	5	trials	trial	NOUN
gs-3751	77	6	,	,	PUNCT
gs-3751	77	7	omics	omics	PROPN
gs-3751	77	8	technologies	technology	NOUN
gs-3751	77	9	,	,	PUNCT
gs-3751	77	10	and	and	CCONJ
gs-3751	77	11	neuroimaging	neuroimaging	NOUN
gs-3751	77	12	will	will	AUX
gs-3751	77	13	be	be	AUX
gs-3751	77	14	critical	critical	ADJ
gs-3751	77	15	to	to	PART
gs-3751	77	16	unravel	unravel	VERB
gs-3751	77	17	these	these	DET
gs-3751	77	18	complexities	complexity	NOUN
gs-3751	77	19	.	.	PUNCT
gs-3751	78	1	by	by	ADP
gs-3751	78	2	bridging	bridge	VERB
gs-3751	78	3	gaps	gap	NOUN
gs-3751	78	4	between	between	ADP
gs-3751	78	5	microbiology	microbiology	NOUN
gs-3751	78	6	,	,	PUNCT
gs-3751	78	7	neurology	neurology	NOUN
gs-3751	78	8	,	,	PUNCT
gs-3751	78	9	and	and	CCONJ
gs-3751	78	10	pharmacology	pharmacology	NOUN
gs-3751	78	11	,	,	PUNCT
gs-3751	78	12	targeting	target	VERB
gs-3751	78	13	the	the	DET
gs-3751	78	14	gut	gut	NOUN
gs-3751	78	15	-	-	PUNCT
gs-3751	78	16	brain	brain	NOUN
gs-3751	78	17	axis	axis	NOUN
gs-3751	78	18	may	may	AUX
gs-3751	78	19	herald	herald	VERB
gs-3751	78	20	a	a	DET
gs-3751	78	21	new	new	ADJ
gs-3751	78	22	era	era	NOUN
gs-3751	78	23	of	of	ADP
gs-3751	78	24	neurodegeneration	neurodegeneration	NOUN
gs-3751	78	25	therapeutics	therapeutic	NOUN
gs-3751	78	26	—	—	PUNCT
gs-3751	78	27	one	one	NUM
gs-3751	78	28	where	where	SCONJ
gs-3751	78	29	the	the	DET
gs-3751	78	30	microbiome	microbiome	NOUN
gs-3751	78	31	is	be	AUX
gs-3751	78	32	not	not	PART
gs-3751	78	33	just	just	ADV
gs-3751	78	34	a	a	DET
gs-3751	78	35	bystander	bystander	NOUN
gs-3751	78	36	but	but	CCONJ
gs-3751	78	37	a	a	DET
gs-3751	78	38	central	central	ADJ
gs-3751	78	39	player	player	NOUN
gs-3751	78	40	in	in	ADP
gs-3751	78	41	brain	brain	NOUN
gs-3751	78	42	health	health	NOUN
gs-3751	78	43	.	.	PUNCT
gs-3751	79	1	georgian	georgian	ADJ
gs-3751	79	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3751	79	3	მეცნიერები	მეცნიერები	NOUN
gs-3751	79	4	ტ.	ტ.	VERB
gs-3751	79	5	7	7	NUM
gs-3751	79	6	n	n	DET
gs-3751	79	7	2	2	NUM
gs-3751	79	8	,	,	PUNCT
gs-3751	79	9	2025	2025	NUM
gs-3751	79	10	334	334	NUM
gs-3751	79	11	the	the	DET
gs-3751	79	12	concept	concept	NOUN
gs-3751	79	13	of	of	ADP
gs-3751	79	14	bidirectional	bidirectional	ADJ
gs-3751	79	15	communication	communication	NOUN
gs-3751	79	16	between	between	ADP
gs-3751	79	17	the	the	DET
gs-3751	79	18	gut	gut	NOUN
gs-3751	79	19	and	and	CCONJ
gs-3751	79	20	the	the	DET
gs-3751	79	21	brain	brain	NOUN
gs-3751	79	22	dates	date	VERB
gs-3751	79	23	back	back	ADV
gs-3751	79	24	to	to	ADP
gs-3751	79	25	ancient	ancient	ADJ
gs-3751	79	26	medical	medical	ADJ
gs-3751	79	27	traditions	tradition	NOUN
gs-3751	79	28	,	,	PUNCT
gs-3751	79	29	but	but	CCONJ
gs-3751	79	30	it	it	PRON
gs-3751	79	31	was	be	AUX
gs-3751	79	32	only	only	ADV
gs-3751	79	33	in	in	ADP
gs-3751	79	34	the	the	DET
gs-3751	79	35	late	late	ADJ
gs-3751	79	36	20th	20th	ADJ
gs-3751	79	37	century	century	NOUN
gs-3751	79	38	that	that	SCONJ
gs-3751	79	39	scientific	scientific	ADJ
gs-3751	79	40	advances	advance	NOUN
gs-3751	79	41	began	begin	VERB
gs-3751	79	42	unraveling	unravel	VERB
gs-3751	79	43	the	the	DET
gs-3751	79	44	molecular	molecular	ADJ
gs-3751	79	45	and	and	CCONJ
gs-3751	79	46	cellular	cellular	ADJ
gs-3751	79	47	underpinnings	underpinning	NOUN
gs-3751	79	48	of	of	ADP
gs-3751	79	49	the	the	DET
gs-3751	79	50	gut	gut	NOUN
gs-3751	79	51	-	-	PUNCT
gs-3751	79	52	brain	brain	NOUN
gs-3751	79	53	axis	axis	NOUN
gs-3751	79	54	.	.	PUNCT
gs-3751	80	1	early	early	ADJ
gs-3751	80	2	observations	observation	NOUN
gs-3751	80	3	,	,	PUNCT
gs-3751	80	4	such	such	ADJ
gs-3751	80	5	as	as	ADP
gs-3751	80	6	the	the	DET
gs-3751	80	7	prevalence	prevalence	NOUN
gs-3751	80	8	of	of	ADP
gs-3751	80	9	gastrointestinal	gastrointestinal	ADJ
gs-3751	80	10	symptoms	symptom	NOUN
gs-3751	80	11	in	in	ADP
gs-3751	80	12	neurological	neurological	ADJ
gs-3751	80	13	disorders	disorder	NOUN
gs-3751	80	14	(	(	PUNCT
gs-3751	80	15	e.g.	e.g.	ADV
gs-3751	80	16	,	,	PUNCT
gs-3751	80	17	constipation	constipation	NOUN
gs-3751	80	18	in	in	ADP
gs-3751	80	19	parkinson	parkinson	NOUN
gs-3751	80	20	’s	’s	PART
gs-3751	80	21	disease	disease	NOUN
gs-3751	80	22	)	)	PUNCT
gs-3751	80	23	,	,	PUNCT
gs-3751	80	24	hinted	hint	VERB
gs-3751	80	25	at	at	ADP
gs-3751	80	26	a	a	DET
gs-3751	80	27	deeper	deep	ADJ
gs-3751	80	28	connection	connection	NOUN
gs-3751	80	29	.	.	PUNCT
gs-3751	81	1	the	the	DET
gs-3751	81	2	advent	advent	NOUN
gs-3751	81	3	of	of	ADP
gs-3751	81	4	high	high	ADJ
gs-3751	81	5	-	-	PUNCT
gs-3751	81	6	throughput	throughput	NOUN
gs-3751	81	7	sequencing	sequencing	NOUN
gs-3751	81	8	and	and	CCONJ
gs-3751	81	9	metabolomics	metabolomic	NOUN
gs-3751	81	10	in	in	ADP
gs-3751	81	11	the	the	DET
gs-3751	81	12	21st	21st	ADJ
gs-3751	81	13	century	century	NOUN
gs-3751	81	14	catalyzed	catalyze	VERB
gs-3751	81	15	a	a	DET
gs-3751	81	16	paradigm	paradigm	NOUN
gs-3751	81	17	shift	shift	NOUN
gs-3751	81	18	,	,	PUNCT
gs-3751	81	19	revealing	reveal	VERB
gs-3751	81	20	the	the	DET
gs-3751	81	21	gut	gut	NOUN
gs-3751	81	22	microbiota	microbiota	NOUN
gs-3751	81	23	—	—	PUNCT
gs-3751	81	24	a	a	DET
gs-3751	81	25	complex	complex	ADJ
gs-3751	81	26	consortium	consortium	NOUN
gs-3751	81	27	of	of	ADP
gs-3751	81	28	bacteria	bacteria	NOUN
gs-3751	81	29	,	,	PUNCT
gs-3751	81	30	viruses	virus	NOUN
gs-3751	81	31	,	,	PUNCT
gs-3751	81	32	fungi	fungus	NOUN
gs-3751	81	33	,	,	PUNCT
gs-3751	81	34	and	and	CCONJ
gs-3751	81	35	archaea	archaea	NOUN
gs-3751	81	36	—	—	PUNCT
gs-3751	81	37	as	as	ADP
gs-3751	81	38	a	a	DET
gs-3751	81	39	key	key	ADJ
gs-3751	81	40	mediator	mediator	NOUN
gs-3751	81	41	of	of	ADP
gs-3751	81	42	this	this	DET
gs-3751	81	43	axis	axis	NOUN
gs-3751	81	44	.	.	PUNCT
gs-3751	82	1	the	the	DET
gs-3751	82	2	human	human	ADJ
gs-3751	82	3	gut	gut	NOUN
gs-3751	82	4	harbors	harbor	NOUN
gs-3751	82	5	over	over	ADP
gs-3751	82	6	100	100	NUM
gs-3751	82	7	trillion	trillion	NUM
gs-3751	82	8	microorganisms	microorganism	NOUN
gs-3751	82	9	,	,	PUNCT
gs-3751	82	10	collectively	collectively	ADV
gs-3751	82	11	encoding	encode	VERB
gs-3751	82	12	150	150	NUM
gs-3751	82	13	times	time	NOUN
gs-3751	82	14	more	more	ADJ
gs-3751	82	15	genetic	genetic	ADJ
gs-3751	82	16	material	material	NOUN
gs-3751	82	17	than	than	ADP
gs-3751	82	18	the	the	DET
gs-3751	82	19	human	human	ADJ
gs-3751	82	20	genome	genome	NOUN
gs-3751	82	21	.	.	PUNCT
gs-3751	83	1	dominated	dominate	VERB
gs-3751	83	2	by	by	ADP
gs-3751	83	3	phyla	phyla	NOUN
gs-3751	83	4	such	such	ADJ
gs-3751	83	5	as	as	ADP
gs-3751	83	6	firmicutes	firmicute	NOUN
gs-3751	83	7	and	and	CCONJ
gs-3751	83	8	bacteroidetes	bacteroidete	NOUN
gs-3751	83	9	,	,	PUNCT
gs-3751	83	10	these	these	DET
gs-3751	83	11	microbes	microbe	NOUN
gs-3751	83	12	perform	perform	VERB
gs-3751	83	13	essential	essential	ADJ
gs-3751	83	14	functions	function	NOUN
gs-3751	83	15	,	,	PUNCT
gs-3751	83	16	including	include	VERB
gs-3751	83	17	fermentation	fermentation	NOUN
gs-3751	83	18	of	of	ADP
gs-3751	83	19	dietary	dietary	ADJ
gs-3751	83	20	fiber	fiber	NOUN
gs-3751	83	21	into	into	ADP
gs-3751	83	22	short	short	ADJ
gs-3751	83	23	-	-	PUNCT
gs-3751	83	24	chain	chain	NOUN
gs-3751	83	25	fatty	fatty	NOUN
gs-3751	83	26	acids	acid	NOUN
gs-3751	83	27	(	(	PUNCT
gs-3751	83	28	scfas	scfas	NOUN
gs-3751	83	29	)	)	PUNCT
gs-3751	83	30	,	,	PUNCT
gs-3751	83	31	synthesis	synthesis	NOUN
gs-3751	83	32	of	of	ADP
gs-3751	83	33	vitamins	vitamin	NOUN
gs-3751	83	34	(	(	PUNCT
gs-3751	83	35	e.g.	e.g.	ADV
gs-3751	83	36	,	,	PUNCT
gs-3751	83	37	b12	b12	NOUN
gs-3751	83	38	,	,	PUNCT
gs-3751	83	39	k	k	NOUN
gs-3751	83	40	)	)	PUNCT
gs-3751	83	41	,	,	PUNCT
gs-3751	83	42	and	and	CCONJ
gs-3751	83	43	modulation	modulation	NOUN
gs-3751	83	44	of	of	ADP
gs-3751	83	45	the	the	DET
gs-3751	83	46	host	host	NOUN
gs-3751	83	47	immune	immune	ADJ
gs-3751	83	48	system	system	NOUN
gs-3751	83	49	.	.	PUNCT
gs-3751	84	1	critically	critically	ADV
gs-3751	84	2	,	,	PUNCT
gs-3751	84	3	they	they	PRON
gs-3751	84	4	also	also	ADV
gs-3751	84	5	produce	produce	VERB
gs-3751	84	6	neurotransmitters	neurotransmitter	NOUN
gs-3751	84	7	(	(	PUNCT
gs-3751	84	8	e.g.	e.g.	ADV
gs-3751	84	9	,	,	PUNCT
gs-3751	84	10	serotonin	serotonin	NOUN
gs-3751	84	11	,	,	PUNCT
gs-3751	84	12	dopamine	dopamine	NOUN
gs-3751	84	13	,	,	PUNCT
gs-3751	84	14	gaba	gaba	NOUN
gs-3751	84	15	)	)	PUNCT
gs-3751	84	16	and	and	CCONJ
gs-3751	84	17	interact	interact	VERB
gs-3751	84	18	with	with	ADP
gs-3751	84	19	the	the	DET
gs-3751	84	20	enteric	enteric	ADJ
gs-3751	84	21	nervous	nervous	ADJ
gs-3751	84	22	system	system	NOUN
gs-3751	84	23	(	(	PUNCT
gs-3751	84	24	ens	ens	PROPN
gs-3751	84	25	)	)	PUNCT
gs-3751	84	26	,	,	PUNCT
gs-3751	84	27	often	often	ADV
gs-3751	84	28	termed	term	VERB
gs-3751	84	29	the	the	DET
gs-3751	84	30	"	"	PUNCT
gs-3751	84	31	second	second	ADJ
gs-3751	84	32	brain	brain	NOUN
gs-3751	84	33	.	.	PUNCT
gs-3751	84	34	"	"	PUNCT
gs-3751	85	1	the	the	DET
gs-3751	85	2	ens	ens	NOUN
gs-3751	85	3	comprises	comprise	VERB
gs-3751	85	4	500	500	NUM
gs-3751	85	5	million	million	NUM
gs-3751	85	6	neurons	neuron	NOUN
gs-3751	85	7	that	that	PRON
gs-3751	85	8	govern	govern	VERB
gs-3751	85	9	gut	gut	NOUN
gs-3751	85	10	motility	motility	NOUN
gs-3751	85	11	and	and	CCONJ
gs-3751	85	12	secretion	secretion	NOUN
gs-3751	85	13	,	,	PUNCT
gs-3751	85	14	while	while	SCONJ
gs-3751	85	15	vagal	vagal	ADJ
gs-3751	85	16	afferents	afferent	NOUN
gs-3751	85	17	relay	relay	NOUN
gs-3751	85	18	signals	signal	NOUN
gs-3751	85	19	to	to	ADP
gs-3751	85	20	the	the	DET
gs-3751	85	21	brainstem	brainstem	NOUN
gs-3751	85	22	and	and	CCONJ
gs-3751	85	23	limbic	limbic	ADJ
gs-3751	85	24	system	system	NOUN
gs-3751	85	25	,	,	PUNCT
gs-3751	85	26	influencing	influence	VERB
gs-3751	85	27	mood	mood	NOUN
gs-3751	85	28	,	,	PUNCT
gs-3751	85	29	cognition	cognition	NOUN
gs-3751	85	30	,	,	PUNCT
gs-3751	85	31	and	and	CCONJ
gs-3751	85	32	stress	stress	NOUN
gs-3751	85	33	responses	response	NOUN
gs-3751	85	34	.	.	PUNCT
gs-3751	86	1	dysregulation	dysregulation	NOUN
gs-3751	86	2	of	of	ADP
gs-3751	86	3	the	the	DET
gs-3751	86	4	gut	gut	NOUN
gs-3751	86	5	-	-	PUNCT
gs-3751	86	6	brain	brain	NOUN
gs-3751	86	7	axis	axis	NOUN
gs-3751	86	8	,	,	PUNCT
gs-3751	86	9	termed	term	VERB
gs-3751	86	10	dysbiosis	dysbiosis	NOUN
gs-3751	86	11	,	,	PUNCT
gs-3751	86	12	has	have	AUX
gs-3751	86	13	been	be	AUX
gs-3751	86	14	linked	link	VERB
gs-3751	86	15	to	to	ADP
gs-3751	86	16	a	a	DET
gs-3751	86	17	spectrum	spectrum	NOUN
gs-3751	86	18	of	of	ADP
gs-3751	86	19	disorders	disorder	NOUN
gs-3751	86	20	,	,	PUNCT
gs-3751	86	21	from	from	ADP
gs-3751	86	22	irritable	irritable	ADJ
gs-3751	86	23	bowel	bowel	NOUN
gs-3751	86	24	syndrome	syndrome	NOUN
gs-3751	86	25	(	(	PUNCT
gs-3751	86	26	ibs	ibs	PROPN
gs-3751	86	27	)	)	PUNCT
gs-3751	86	28	to	to	ADP
gs-3751	86	29	depression	depression	NOUN
gs-3751	86	30	.	.	PUNCT
gs-3751	87	1	in	in	ADP
gs-3751	87	2	neurodegenerative	neurodegenerative	ADJ
gs-3751	87	3	contexts	contexts	NOUN
gs-3751	87	4	,	,	PUNCT
gs-3751	87	5	dysbiosis	dysbiosis	NOUN
gs-3751	87	6	disrupts	disrupt	VERB
gs-3751	87	7	gut	gut	NOUN
gs-3751	87	8	barrier	barrier	NOUN
gs-3751	87	9	integrity	integrity	NOUN
gs-3751	87	10	,	,	PUNCT
gs-3751	87	11	enabling	enable	VERB
gs-3751	87	12	translocation	translocation	NOUN
gs-3751	87	13	of	of	ADP
gs-3751	87	14	bacterial	bacterial	ADJ
gs-3751	87	15	endotoxins	endotoxin	NOUN
gs-3751	87	16	like	like	ADP
gs-3751	87	17	lipopolysaccharides	lipopolysaccharide	NOUN
gs-3751	87	18	(	(	PUNCT
gs-3751	87	19	lps	lps	PROPN
gs-3751	87	20	)	)	PUNCT
gs-3751	87	21	into	into	ADP
gs-3751	87	22	systemic	systemic	ADJ
gs-3751	87	23	circulation	circulation	NOUN
gs-3751	87	24	.	.	PUNCT
gs-3751	88	1	these	these	DET
gs-3751	88	2	toxins	toxin	NOUN
gs-3751	88	3	trigger	trigger	NOUN
gs-3751	88	4	chronic	chronic	ADJ
gs-3751	88	5	neuroinflammation	neuroinflammation	NOUN
gs-3751	88	6	and	and	CCONJ
gs-3751	88	7	oxidative	oxidative	ADJ
gs-3751	88	8	stress	stress	NOUN
gs-3751	88	9	,	,	PUNCT
gs-3751	88	10	exacerbating	exacerbate	VERB
gs-3751	88	11	neuronal	neuronal	ADJ
gs-3751	88	12	damage	damage	NOUN
gs-3751	88	13	.	.	PUNCT
gs-3751	89	1	for	for	ADP
gs-3751	89	2	example	example	NOUN
gs-3751	89	3	,	,	PUNCT
gs-3751	89	4	lps	lps	PROPN
gs-3751	89	5	activates	activate	VERB
gs-3751	89	6	microglia	microglia	NOUN
gs-3751	89	7	,	,	PUNCT
gs-3751	89	8	the	the	DET
gs-3751	89	9	brain	brain	NOUN
gs-3751	89	10	’s	’s	PART
gs-3751	89	11	resident	resident	ADJ
gs-3751	89	12	immune	immune	ADJ
gs-3751	89	13	cells	cell	NOUN
gs-3751	89	14	,	,	PUNCT
gs-3751	89	15	leading	lead	VERB
gs-3751	89	16	to	to	ADP
gs-3751	89	17	overproduction	overproduction	NOUN
gs-3751	89	18	of	of	ADP
gs-3751	89	19	pro	pro	ADJ
gs-3751	89	20	-	-	ADJ
gs-3751	89	21	inflammatory	inflammatory	ADJ
gs-3751	89	22	cytokines	cytokine	NOUN
gs-3751	89	23	(	(	PUNCT
gs-3751	89	24	il-1β	il-1β	PROPN
gs-3751	89	25	,	,	PUNCT
gs-3751	89	26	tnf	tnf	PROPN
gs-3751	89	27	-	-	PUNCT
gs-3751	89	28	α	α	NOUN
gs-3751	89	29	)	)	PUNCT
gs-3751	89	30	and	and	CCONJ
gs-3751	89	31	impaired	impaired	ADJ
gs-3751	89	32	clearance	clearance	NOUN
gs-3751	89	33	of	of	ADP
gs-3751	89	34	pathological	pathological	ADJ
gs-3751	89	35	proteins	protein	NOUN
gs-3751	89	36	like	like	ADP
gs-3751	89	37	alpha	alpha	NOUN
gs-3751	89	38	-	-	PUNCT
gs-3751	89	39	synuclein	synuclein	NOUN
gs-3751	89	40	and	and	CCONJ
gs-3751	89	41	amyloid	amyloid	NOUN
gs-3751	89	42	-	-	PUNCT
gs-3751	89	43	beta	beta	NOUN
gs-3751	89	44	.	.	PUNCT
gs-3751	90	1			VERB
gs-3751	90	2	the	the	DET
gs-3751	90	3	microbiome	microbiome	NOUN
gs-3751	90	4	’s	’s	PART
gs-3751	90	5	role	role	NOUN
gs-3751	90	6	in	in	ADP
gs-3751	90	7	neurodegeneration	neurodegeneration	NOUN
gs-3751	90	8	neurodegenerative	neurodegenerative	ADJ
gs-3751	90	9	diseases	disease	NOUN
gs-3751	90	10	like	like	ADP
gs-3751	90	11	parkinson	parkinson	NOUN
gs-3751	90	12	’s	’s	PART
gs-3751	90	13	(	(	PUNCT
gs-3751	90	14	pd	pd	NOUN
gs-3751	90	15	)	)	PUNCT
gs-3751	90	16	and	and	CCONJ
gs-3751	90	17	alzheimer	alzheimer	PROPN
gs-3751	90	18	’s	’s	PART
gs-3751	90	19	(	(	PUNCT
gs-3751	90	20	ad	ad	NOUN
gs-3751	90	21	)	)	PUNCT
gs-3751	90	22	are	be	AUX
gs-3751	90	23	characterized	characterize	VERB
gs-3751	90	24	by	by	ADP
gs-3751	90	25	progressive	progressive	ADJ
gs-3751	90	26	loss	loss	NOUN
gs-3751	90	27	of	of	ADP
gs-3751	90	28	neurons	neuron	NOUN
gs-3751	90	29	and	and	CCONJ
gs-3751	90	30	accumulation	accumulation	NOUN
gs-3751	90	31	of	of	ADP
gs-3751	90	32	misfolded	misfolde	VERB
gs-3751	90	33	proteins	protein	NOUN
gs-3751	90	34	.	.	PUNCT
gs-3751	91	1	emerging	emerge	VERB
gs-3751	91	2	evidence	evidence	NOUN
gs-3751	91	3	suggests	suggest	VERB
gs-3751	91	4	the	the	DET
gs-3751	91	5	microbiome	microbiome	NOUN
gs-3751	91	6	influences	influence	VERB
gs-3751	91	7	these	these	DET
gs-3751	91	8	processes	process	NOUN
gs-3751	91	9	through	through	ADP
gs-3751	91	10	:	:	PUNCT
gs-3751	91	11	protein	protein	NOUN
gs-3751	91	12	aggregation	aggregation	NOUN
gs-3751	91	13	:	:	PUNCT
gs-3751	91	14	gut	gut	NOUN
gs-3751	91	15	-	-	PUNCT
gs-3751	91	16	derived	derive	VERB
gs-3751	91	17	metabolites	metabolite	NOUN
gs-3751	91	18	(	(	PUNCT
gs-3751	91	19	e.g.	e.g.	ADV
gs-3751	91	20	,	,	PUNCT
gs-3751	91	21	curli	curli	ADJ
gs-3751	91	22	amyloid	amyloid	NOUN
gs-3751	91	23	from	from	ADP
gs-3751	91	24	e.	e.	PROPN
gs-3751	91	25	coli	coli	PROPN
gs-3751	91	26	)	)	PUNCT
gs-3751	91	27	may	may	AUX
gs-3751	91	28	cross	cross	VERB
gs-3751	91	29	-	-	ADJ
gs-3751	91	30	seed	seed	ADJ
gs-3751	91	31	aggregation	aggregation	NOUN
gs-3751	91	32	of	of	ADP
gs-3751	91	33	alpha	alpha	NOUN
gs-3751	91	34	-	-	PUNCT
gs-3751	91	35	synuclein	synuclein	NOUN
gs-3751	91	36	or	or	CCONJ
gs-3751	91	37	amyloid	amyloid	NOUN
gs-3751	91	38	-	-	PUNCT
gs-3751	91	39	beta	beta	NOUN
gs-3751	91	40	.	.	PUNCT
gs-3751	92	1	mitochondrial	mitochondrial	ADJ
gs-3751	92	2	dysfunction	dysfunction	NOUN
gs-3751	92	3	:	:	PUNCT
gs-3751	92	4	microbial	microbial	ADJ
gs-3751	92	5	metabolites	metabolite	NOUN
gs-3751	92	6	like	like	ADP
gs-3751	92	7	hydrogen	hydrogen	NOUN
gs-3751	92	8	sulfide	sulfide	NOUN
gs-3751	92	9	impair	impair	VERB
gs-3751	92	10	mitochondrial	mitochondrial	ADJ
gs-3751	92	11	respiration	respiration	NOUN
gs-3751	92	12	,	,	PUNCT
gs-3751	92	13	increasing	increase	VERB
gs-3751	92	14	neuronal	neuronal	ADJ
gs-3751	92	15	vulnerability	vulnerability	NOUN
gs-3751	92	16	.	.	PUNCT
gs-3751	93	1	blood	blood	NOUN
gs-3751	93	2	-	-	PUNCT
gs-3751	93	3	brain	brain	NOUN
gs-3751	93	4	barrier	barrier	NOUN
gs-3751	93	5	(	(	PUNCT
gs-3751	93	6	bbb	bbb	NOUN
gs-3751	93	7	)	)	PUNCT
gs-3751	93	8	breakdown	breakdown	NOUN
gs-3751	93	9	:	:	PUNCT
gs-3751	93	10	dysbiosis	dysbiosis	NOUN
gs-3751	93	11	reduces	reduce	VERB
gs-3751	93	12	scfa	scfa	ADJ
gs-3751	93	13	production	production	NOUN
gs-3751	93	14	,	,	PUNCT
gs-3751	93	15	weakening	weaken	VERB
gs-3751	93	16	bbb	bbb	NOUN
gs-3751	93	17	integrity	integrity	NOUN
gs-3751	93	18	and	and	CCONJ
gs-3751	93	19	permitting	permit	VERB
gs-3751	93	20	neurotoxic	neurotoxic	ADJ
gs-3751	93	21	compounds	compound	NOUN
gs-3751	93	22	to	to	PART
gs-3751	93	23	infiltrate	infiltrate	VERB
gs-3751	93	24	the	the	DET
gs-3751	93	25	brain	brain	NOUN
gs-3751	93	26	.	.	PUNCT
gs-3751	94	1			VERB
gs-3751	94	2	limitations	limitation	NOUN
gs-3751	94	3	of	of	ADP
gs-3751	94	4	current	current	ADJ
gs-3751	94	5	pharmacotherapies	pharmacotherapie	NOUN
gs-3751	94	6	existing	exist	VERB
gs-3751	94	7	treatments	treatment	NOUN
gs-3751	94	8	for	for	ADP
gs-3751	94	9	pd	pd	PROPN
gs-3751	94	10	(	(	PUNCT
gs-3751	94	11	e.g.	e.g.	ADJ
gs-3751	94	12	,	,	PUNCT
gs-3751	94	13	levodopa	levodopa	NOUN
gs-3751	94	14	)	)	PUNCT
gs-3751	94	15	and	and	CCONJ
gs-3751	94	16	ad	ad	NOUN
gs-3751	94	17	(	(	PUNCT
gs-3751	94	18	e.g.	e.g.	ADV
gs-3751	94	19	,	,	PUNCT
gs-3751	94	20	donepezil	donepezil	NOUN
gs-3751	94	21	)	)	PUNCT
gs-3751	94	22	focus	focus	VERB
gs-3751	94	23	on	on	ADP
gs-3751	94	24	symptom	symptom	NOUN
gs-3751	94	25	management	management	NOUN
gs-3751	94	26	rather	rather	ADV
gs-3751	94	27	than	than	ADP
gs-3751	94	28	disease	disease	NOUN
gs-3751	94	29	modification	modification	NOUN
gs-3751	94	30	.	.	PUNCT
gs-3751	95	1	they	they	PRON
gs-3751	95	2	often	often	ADV
gs-3751	95	3	fail	fail	VERB
gs-3751	95	4	to	to	PART
gs-3751	95	5	address	address	VERB
gs-3751	95	6	underlying	underlying	ADJ
gs-3751	95	7	mechanisms	mechanism	NOUN
gs-3751	95	8	like	like	ADP
gs-3751	95	9	neuroinflammation	neuroinflammation	NOUN
gs-3751	95	10	or	or	CCONJ
gs-3751	95	11	protein	protein	NOUN
gs-3751	95	12	misfolding	misfolde	VERB
gs-3751	95	13	.	.	PUNCT
gs-3751	96	1	moreover	moreover	ADV
gs-3751	96	2	,	,	PUNCT
gs-3751	96	3	long	long	ADJ
gs-3751	96	4	-	-	PUNCT
gs-3751	96	5	term	term	NOUN
gs-3751	96	6	use	use	NOUN
gs-3751	96	7	of	of	ADP
gs-3751	96	8	these	these	DET
gs-3751	96	9	drugs	drug	NOUN
gs-3751	96	10	is	be	AUX
gs-3751	96	11	marred	mar	VERB
gs-3751	96	12	by	by	ADP
gs-3751	96	13	side	side	NOUN
gs-3751	96	14	effects	effect	NOUN
gs-3751	96	15	(	(	PUNCT
gs-3751	96	16	e.g.	e.g.	ADV
gs-3751	96	17	,	,	PUNCT
gs-3751	96	18	dyskinesias	dyskinesia	NOUN
gs-3751	96	19	in	in	ADP
gs-3751	96	20	pd	pd	PROPN
gs-3751	96	21	)	)	PUNCT
gs-3751	96	22	and	and	CCONJ
gs-3751	96	23	diminishing	diminish	VERB
gs-3751	96	24	efficacy	efficacy	NOUN
gs-3751	96	25	.	.	PUNCT
gs-3751	97	1	this	this	DET
gs-3751	97	2	therapeutic	therapeutic	ADJ
gs-3751	97	3	stagnation	stagnation	NOUN
gs-3751	97	4	underscores	underscore	VERB
gs-3751	97	5	the	the	DET
gs-3751	97	6	urgency	urgency	NOUN
gs-3751	97	7	of	of	ADP
gs-3751	97	8	exploring	explore	VERB
gs-3751	97	9	microbiota	microbiota	NOUN
gs-3751	97	10	-	-	PUNCT
gs-3751	97	11	targeted	target	VERB
gs-3751	97	12	strategies	strategy	NOUN
gs-3751	97	13	,	,	PUNCT
gs-3751	97	14	which	which	PRON
gs-3751	97	15	aim	aim	VERB
gs-3751	97	16	to	to	PART
gs-3751	97	17	rectify	rectify	VERB
gs-3751	97	18	upstream	upstream	ADJ
gs-3751	97	19	pathological	pathological	ADJ
gs-3751	97	20	triggers	trigger	NOUN
gs-3751	97	21	rather	rather	ADV
gs-3751	97	22	than	than	ADP
gs-3751	97	23	downstream	downstream	ADJ
gs-3751	97	24	symptoms	symptom	NOUN
gs-3751	97	25	.	.	PUNCT
gs-3751	98	1	georgian	georgian	ADJ
gs-3751	98	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3751	98	3	მეცნიერები	მეცნიერები	NOUN
gs-3751	98	4	ტ.	ტ.	VERB
gs-3751	98	5	7	7	NUM
gs-3751	98	6	n	n	PRON
gs-3751	98	7	2	2	NUM
gs-3751	98	8	,	,	PUNCT
gs-3751	98	9	2025	2025	NUM
gs-3751	98	10	335	335	NUM
gs-3751	98	11			VERB
gs-3751	98	12	the	the	DET
gs-3751	98	13	promise	promise	NOUN
gs-3751	98	14	of	of	ADP
gs-3751	98	15	microbiome	microbiome	NOUN
gs-3751	98	16	-	-	PUNCT
gs-3751	98	17	based	base	VERB
gs-3751	98	18	interventions	intervention	NOUN
gs-3751	98	19	preclinical	preclinical	ADJ
gs-3751	98	20	studies	study	NOUN
gs-3751	98	21	demonstrate	demonstrate	VERB
gs-3751	98	22	that	that	SCONJ
gs-3751	98	23	modulating	modulate	VERB
gs-3751	98	24	the	the	DET
gs-3751	98	25	gut	gut	NOUN
gs-3751	98	26	microbiota	microbiota	NOUN
gs-3751	98	27	via	via	ADP
gs-3751	98	28	probiotics	probiotic	NOUN
gs-3751	98	29	,	,	PUNCT
gs-3751	98	30	prebiotics	prebiotic	NOUN
gs-3751	98	31	,	,	PUNCT
gs-3751	98	32	or	or	CCONJ
gs-3751	98	33	fecal	fecal	ADJ
gs-3751	98	34	microbiota	microbiota	NOUN
gs-3751	98	35	transplantation	transplantation	NOUN
gs-3751	98	36	(	(	PUNCT
gs-3751	98	37	fmt	fmt	NOUN
gs-3751	98	38	)	)	PUNCT
gs-3751	98	39	can	can	AUX
gs-3751	98	40	attenuate	attenuate	VERB
gs-3751	98	41	neuroinflammation	neuroinflammation	NOUN
gs-3751	98	42	,	,	PUNCT
gs-3751	98	43	enhance	enhance	NOUN
gs-3751	98	44	neurogenesis	neurogenesis	NOUN
gs-3751	98	45	,	,	PUNCT
gs-3751	98	46	and	and	CCONJ
gs-3751	98	47	reduce	reduce	VERB
gs-3751	98	48	pathological	pathological	ADJ
gs-3751	98	49	protein	protein	NOUN
gs-3751	98	50	burden	burden	NOUN
gs-3751	98	51	.	.	PUNCT
gs-3751	99	1	for	for	ADP
gs-3751	99	2	instance	instance	NOUN
gs-3751	99	3	,	,	PUNCT
gs-3751	99	4	lactobacillus	lactobacillus	NOUN
gs-3751	99	5	plantarum	plantarum	NOUN
gs-3751	99	6	ps128	ps128	NOUN
gs-3751	99	7	improves	improve	VERB
gs-3751	99	8	motor	motor	NOUN
gs-3751	99	9	function	function	NOUN
gs-3751	99	10	in	in	ADP
gs-3751	99	11	pd	pd	NOUN
gs-3751	99	12	models	model	NOUN
gs-3751	99	13	by	by	ADP
gs-3751	99	14	increasing	increase	VERB
gs-3751	99	15	dopamine	dopamine	NOUN
gs-3751	99	16	synthesis	synthesis	NOUN
gs-3751	99	17	,	,	PUNCT
gs-3751	99	18	while	while	SCONJ
gs-3751	99	19	butyrate	butyrate	ADJ
gs-3751	99	20	supplementation	supplementation	NOUN
gs-3751	99	21	in	in	ADP
gs-3751	99	22	ad	ad	NOUN
gs-3751	99	23	mice	mouse	NOUN
gs-3751	99	24	restores	restore	VERB
gs-3751	99	25	synaptic	synaptic	ADJ
gs-3751	99	26	plasticity	plasticity	NOUN
gs-3751	99	27	.	.	PUNCT
gs-3751	100	1	however	however	ADV
gs-3751	100	2	,	,	PUNCT
gs-3751	100	3	translating	translate	VERB
gs-3751	100	4	these	these	DET
gs-3751	100	5	findings	finding	NOUN
gs-3751	100	6	to	to	ADP
gs-3751	100	7	humans	human	NOUN
gs-3751	100	8	requires	require	VERB
gs-3751	100	9	addressing	address	VERB
gs-3751	100	10	challenges	challenge	NOUN
gs-3751	100	11	such	such	ADJ
gs-3751	100	12	as	as	ADP
gs-3751	100	13	microbial	microbial	ADJ
gs-3751	100	14	strain	strain	NOUN
gs-3751	100	15	specificity	specificity	NOUN
gs-3751	100	16	,	,	PUNCT
gs-3751	100	17	interindividual	interindividual	ADJ
gs-3751	100	18	variability	variability	NOUN
gs-3751	100	19	,	,	PUNCT
gs-3751	100	20	and	and	CCONJ
gs-3751	100	21	the	the	DET
gs-3751	100	22	dynamic	dynamic	ADJ
gs-3751	100	23	nature	nature	NOUN
gs-3751	100	24	of	of	ADP
gs-3751	100	25	the	the	DET
gs-3751	100	26	microbiome	microbiome	NOUN
gs-3751	100	27	.	.	PUNCT
gs-3751	101	1	methodology	methodology	NOUN
gs-3751	101	2	the	the	DET
gs-3751	101	3	methodology	methodology	NOUN
gs-3751	101	4	integrates	integrate	VERB
gs-3751	101	5	reductionist	reductionist	NOUN
gs-3751	101	6	and	and	CCONJ
gs-3751	101	7	systems	system	NOUN
gs-3751	101	8	-	-	PUNCT
gs-3751	101	9	level	level	NOUN
gs-3751	101	10	approaches	approach	NOUN
gs-3751	101	11	to	to	PART
gs-3751	101	12	unravel	unravel	VERB
gs-3751	101	13	the	the	DET
gs-3751	101	14	gba	gba	NOUN
gs-3751	101	15	’s	’s	PART
gs-3751	101	16	role	role	NOUN
gs-3751	101	17	in	in	ADP
gs-3751	101	18	neurodegeneration	neurodegeneration	NOUN
gs-3751	101	19	.	.	PUNCT
gs-3751	102	1	by	by	ADP
gs-3751	102	2	bridging	bridge	VERB
gs-3751	102	3	microbial	microbial	ADJ
gs-3751	102	4	ecology	ecology	NOUN
gs-3751	102	5	,	,	PUNCT
gs-3751	102	6	neurology	neurology	NOUN
gs-3751	102	7	,	,	PUNCT
gs-3751	102	8	and	and	CCONJ
gs-3751	102	9	computational	computational	ADJ
gs-3751	102	10	biology	biology	NOUN
gs-3751	102	11	,	,	PUNCT
gs-3751	102	12	the	the	DET
gs-3751	102	13	framework	framework	NOUN
gs-3751	102	14	provides	provide	VERB
gs-3751	102	15	a	a	DET
gs-3751	102	16	robust	robust	ADJ
gs-3751	102	17	scaffold	scaffold	NOUN
gs-3751	102	18	for	for	ADP
gs-3751	102	19	translating	translate	VERB
gs-3751	102	20	microbiome	microbiome	ADJ
gs-3751	102	21	insights	insight	NOUN
gs-3751	102	22	into	into	ADP
gs-3751	102	23	therapeutic	therapeutic	ADJ
gs-3751	102	24	breakthroughs	breakthrough	NOUN
gs-3751	102	25	.	.	PUNCT
gs-3751	103	1	future	future	ADJ
gs-3751	103	2	iterations	iteration	NOUN
gs-3751	103	3	will	will	AUX
gs-3751	103	4	incorporate	incorporate	VERB
gs-3751	103	5	real	real	ADJ
gs-3751	103	6	-	-	PUNCT
gs-3751	103	7	world	world	NOUN
gs-3751	103	8	data	datum	NOUN
gs-3751	103	9	(	(	PUNCT
gs-3751	103	10	wearables	wearable	NOUN
gs-3751	103	11	,	,	PUNCT
gs-3751	103	12	electronic	electronic	ADJ
gs-3751	103	13	health	health	NOUN
gs-3751	103	14	records	record	NOUN
gs-3751	103	15	)	)	PUNCT
gs-3751	103	16	and	and	CCONJ
gs-3751	103	17	crispr	crispr	NOUN
gs-3751	103	18	-	-	PUNCT
gs-3751	103	19	based	base	VERB
gs-3751	103	20	functional	functional	ADJ
gs-3751	103	21	validation	validation	NOUN
gs-3751	103	22	to	to	PART
gs-3751	103	23	refine	refine	VERB
gs-3751	103	24	causal	causal	ADJ
gs-3751	103	25	inferences	inference	NOUN
gs-3751	103	26	.	.	PUNCT
gs-3751	104	1			ADJ
gs-3751	104	2	study	study	NOUN
gs-3751	104	3	design	design	NOUN
gs-3751	104	4	and	and	CCONJ
gs-3751	104	5	data	datum	NOUN
gs-3751	104	6	sources	source	NOUN
gs-3751	104	7	a	a	DET
gs-3751	104	8	systematic	systematic	ADJ
gs-3751	104	9	review	review	NOUN
gs-3751	104	10	and	and	CCONJ
gs-3751	104	11	meta	meta	ADJ
gs-3751	104	12	-	-	PUNCT
gs-3751	104	13	analysis	analysis	NOUN
gs-3751	104	14	framework	framework	NOUN
gs-3751	104	15	guided	guide	VERB
gs-3751	104	16	the	the	DET
gs-3751	104	17	synthesis	synthesis	NOUN
gs-3751	104	18	of	of	ADP
gs-3751	104	19	evidence	evidence	NOUN
gs-3751	104	20	from	from	ADP
gs-3751	104	21	peerreviewed	peerreviewe	VERB
gs-3751	104	22	literature	literature	NOUN
gs-3751	104	23	,	,	PUNCT
gs-3751	104	24	clinical	clinical	ADJ
gs-3751	104	25	trials	trial	NOUN
gs-3751	104	26	,	,	PUNCT
gs-3751	104	27	and	and	CCONJ
gs-3751	104	28	preclinical	preclinical	ADJ
gs-3751	104	29	studies	study	NOUN
gs-3751	104	30	.	.	PUNCT
gs-3751	105	1	databases	database	NOUN
gs-3751	105	2	including	include	VERB
gs-3751	105	3	pubmed	pubmed	PROPN
gs-3751	105	4	,	,	PUNCT
gs-3751	105	5	scopus	scopus	PROPN
gs-3751	105	6	,	,	PUNCT
gs-3751	105	7	web	web	NOUN
gs-3751	105	8	of	of	ADP
gs-3751	105	9	science	science	NOUN
gs-3751	105	10	,	,	PUNCT
gs-3751	105	11	and	and	CCONJ
gs-3751	105	12	embase	embase	NOUN
gs-3751	105	13	were	be	AUX
gs-3751	105	14	queried	query	VERB
gs-3751	105	15	using	use	VERB
gs-3751	105	16	keywords	keyword	NOUN
gs-3751	105	17	such	such	ADJ
gs-3751	105	18	as	as	ADP
gs-3751	105	19	“	"	PUNCT
gs-3751	105	20	gut	gut	NOUN
gs-3751	105	21	-	-	PUNCT
gs-3751	105	22	brain	brain	NOUN
gs-3751	105	23	axis	axis	NOUN
gs-3751	105	24	,	,	PUNCT
gs-3751	105	25	”	"	PUNCT
gs-3751	105	26	“	"	PUNCT
gs-3751	105	27	microbiome	microbiome	ADJ
gs-3751	105	28	,	,	PUNCT
gs-3751	105	29	”	"	PUNCT
gs-3751	105	30	“	"	PUNCT
gs-3751	105	31	neurodegeneration	neurodegeneration	NOUN
gs-3751	105	32	,	,	PUNCT
gs-3751	105	33	”	"	PUNCT
gs-3751	105	34	“	"	PUNCT
gs-3751	105	35	alzheimer	alzheimer	PROPN
gs-3751	105	36	’s	’s	PART
gs-3751	105	37	disease	disease	NOUN
gs-3751	105	38	,	,	PUNCT
gs-3751	105	39	”	"	PUNCT
gs-3751	105	40	“	"	PUNCT
gs-3751	105	41	parkinson	parkinson	NOUN
gs-3751	105	42	’s	’s	PART
gs-3751	105	43	disease	disease	NOUN
gs-3751	105	44	,	,	PUNCT
gs-3751	105	45	”	"	PUNCT
gs-3751	105	46	“	"	PUNCT
gs-3751	105	47	short	short	ADJ
gs-3751	105	48	-	-	PUNCT
gs-3751	105	49	chain	chain	NOUN
gs-3751	105	50	fatty	fatty	NOUN
gs-3751	105	51	acids	acid	NOUN
gs-3751	105	52	(	(	PUNCT
gs-3751	105	53	scfas	scfas	NOUN
gs-3751	105	54	)	)	PUNCT
gs-3751	105	55	,	,	PUNCT
gs-3751	105	56	”	"	PUNCT
gs-3751	105	57	“	"	PUNCT
gs-3751	105	58	tmao	tmao	PROPN
gs-3751	105	59	,	,	PUNCT
gs-3751	105	60	”	"	PUNCT
gs-3751	105	61	and	and	CCONJ
gs-3751	105	62	“	"	PUNCT
gs-3751	105	63	fecal	fecal	ADJ
gs-3751	105	64	microbiota	microbiota	NOUN
gs-3751	105	65	transplantation	transplantation	NOUN
gs-3751	105	66	(	(	PUNCT
gs-3751	105	67	fmt	fmt	NOUN
gs-3751	105	68	)	)	PUNCT
gs-3751	105	69	.	.	PUNCT
gs-3751	105	70	”	"	PUNCT
gs-3751	106	1	inclusion	inclusion	NOUN
gs-3751	106	2	criteria	criterion	NOUN
gs-3751	106	3	prioritized	prioritize	VERB
gs-3751	106	4	studies	study	NOUN
gs-3751	106	5	published	publish	VERB
gs-3751	106	6	between	between	ADP
gs-3751	106	7	2010–2024	2010–2024	NUM
gs-3751	106	8	to	to	PART
gs-3751	106	9	capture	capture	VERB
gs-3751	106	10	recent	recent	ADJ
gs-3751	106	11	advances	advance	NOUN
gs-3751	106	12	,	,	PUNCT
gs-3751	106	13	with	with	ADP
gs-3751	106	14	no	no	DET
gs-3751	106	15	language	language	NOUN
gs-3751	106	16	restrictions	restriction	NOUN
gs-3751	106	17	.	.	PUNCT
gs-3751	107	1	gray	gray	ADJ
gs-3751	107	2	literature	literature	NOUN
gs-3751	107	3	,	,	PUNCT
gs-3751	107	4	including	include	VERB
gs-3751	107	5	conference	conference	NOUN
gs-3751	107	6	abstracts	abstract	NOUN
gs-3751	107	7	and	and	CCONJ
gs-3751	107	8	preprint	preprint	NOUN
gs-3751	107	9	repositories	repository	NOUN
gs-3751	107	10	(	(	PUNCT
gs-3751	107	11	e.g.	e.g.	ADV
gs-3751	107	12	,	,	PUNCT
gs-3751	107	13	biorxiv	biorxiv	PROPN
gs-3751	107	14	)	)	PUNCT
gs-3751	107	15	,	,	PUNCT
gs-3751	107	16	was	be	AUX
gs-3751	107	17	screened	screen	VERB
gs-3751	107	18	to	to	PART
gs-3751	107	19	identify	identify	VERB
gs-3751	107	20	emerging	emerge	VERB
gs-3751	107	21	trends	trend	NOUN
gs-3751	107	22	.	.	PUNCT
gs-3751	108	1			ADJ
gs-3751	108	2	preclinical	preclinical	ADJ
gs-3751	108	3	studies	study	NOUN
gs-3751	108	4	:	:	PUNCT
gs-3751	108	5	animal	animal	NOUN
gs-3751	108	6	models	model	NOUN
gs-3751	108	7	of	of	ADP
gs-3751	108	8	ad	ad	NOUN
gs-3751	108	9	(	(	PUNCT
gs-3751	108	10	e.g.	e.g.	ADV
gs-3751	108	11	,	,	PUNCT
gs-3751	108	12	app	app	ADJ
gs-3751	108	13	/	/	SYM
gs-3751	108	14	ps1	ps1	NOUN
gs-3751	108	15	mice	mouse	NOUN
gs-3751	108	16	,	,	PUNCT
gs-3751	108	17	5xfad	5xfad	NUM
gs-3751	108	18	)	)	PUNCT
gs-3751	108	19	and	and	CCONJ
gs-3751	108	20	pd	pd	PROPN
gs-3751	108	21	(	(	PUNCT
gs-3751	108	22	e.g.	e.g.	ADV
gs-3751	108	23	,	,	PUNCT
gs-3751	108	24	α	α	X
gs-3751	108	25	-	-	PUNCT
gs-3751	108	26	synuclein	synuclein	NOUN
gs-3751	108	27	overexpression	overexpression	NOUN
gs-3751	108	28	,	,	PUNCT
gs-3751	108	29	mptp/6	mptp/6	NOUN
gs-3751	108	30	-	-	PUNCT
gs-3751	108	31	ohda	ohda	ADJ
gs-3751	108	32	toxin	toxin	NOUN
gs-3751	108	33	models	model	NOUN
gs-3751	108	34	)	)	PUNCT
gs-3751	108	35	were	be	AUX
gs-3751	108	36	analyzed	analyze	VERB
gs-3751	108	37	to	to	PART
gs-3751	108	38	assess	assess	VERB
gs-3751	108	39	causality	causality	NOUN
gs-3751	108	40	between	between	ADP
gs-3751	108	41	gut	gut	NOUN
gs-3751	108	42	dysbiosis	dysbiosis	NOUN
gs-3751	108	43	and	and	CCONJ
gs-3751	108	44	neurodegeneration	neurodegeneration	NOUN
gs-3751	108	45	.	.	PUNCT
gs-3751	109	1	germ	germ	NOUN
gs-3751	109	2	-	-	PUNCT
gs-3751	109	3	free	free	ADJ
gs-3751	109	4	(	(	PUNCT
gs-3751	109	5	gf	gf	NOUN
gs-3751	109	6	)	)	PUNCT
gs-3751	109	7	and	and	CCONJ
gs-3751	109	8	gnotobiotic	gnotobiotic	ADJ
gs-3751	109	9	models	model	NOUN
gs-3751	109	10	colonized	colonize	VERB
gs-3751	109	11	with	with	ADP
gs-3751	109	12	human	human	NOUN
gs-3751	109	13	-	-	PUNCT
gs-3751	109	14	derived	derive	VERB
gs-3751	109	15	microbiota	microbiota	NOUN
gs-3751	109	16	were	be	AUX
gs-3751	109	17	prioritized	prioritize	VERB
gs-3751	109	18	to	to	PART
gs-3751	109	19	isolate	isolate	VERB
gs-3751	109	20	microbial	microbial	ADJ
gs-3751	109	21	contributions	contribution	NOUN
gs-3751	109	22	.	.	PUNCT
gs-3751	110	1	behavioral	behavioral	ADJ
gs-3751	110	2	assays	assay	NOUN
gs-3751	110	3	(	(	PUNCT
gs-3751	110	4	morris	morris	PROPN
gs-3751	110	5	water	water	NOUN
gs-3751	110	6	maze	maze	NOUN
gs-3751	110	7	,	,	PUNCT
gs-3751	110	8	rotarod	rotarod	NOUN
gs-3751	110	9	)	)	PUNCT
gs-3751	110	10	and	and	CCONJ
gs-3751	110	11	histopathological	histopathological	ADJ
gs-3751	110	12	analyses	analysis	NOUN
gs-3751	110	13	(	(	PUNCT
gs-3751	110	14	aβ	aβ	NOUN
gs-3751	110	15	plaques	plaque	NOUN
gs-3751	110	16	,	,	PUNCT
gs-3751	110	17	α	α	X
gs-3751	110	18	-	-	PUNCT
gs-3751	110	19	synuclein	synuclein	NOUN
gs-3751	110	20	aggregates	aggregate	NOUN
gs-3751	110	21	)	)	PUNCT
gs-3751	110	22	provided	provide	VERB
gs-3751	110	23	functional	functional	ADJ
gs-3751	110	24	and	and	CCONJ
gs-3751	110	25	structural	structural	ADJ
gs-3751	110	26	endpoints	endpoint	NOUN
gs-3751	110	27	.	.	PUNCT
gs-3751	111	1			ADJ
gs-3751	111	2	clinical	clinical	ADJ
gs-3751	111	3	studies	study	NOUN
gs-3751	111	4	:	:	PUNCT
gs-3751	111	5	human	human	ADJ
gs-3751	111	6	cohorts	cohort	NOUN
gs-3751	111	7	included	include	VERB
gs-3751	111	8	longitudinal	longitudinal	ADJ
gs-3751	111	9	observational	observational	ADJ
gs-3751	111	10	studies	study	NOUN
gs-3751	111	11	(	(	PUNCT
gs-3751	111	12	e.g.	e.g.	ADV
gs-3751	111	13	,	,	PUNCT
gs-3751	111	14	ad	ad	NOUN
gs-3751	111	15	gut	gut	NOUN
gs-3751	111	16	microbiome	microbiome	NOUN
gs-3751	111	17	project	project	NOUN
gs-3751	111	18	,	,	PUNCT
gs-3751	111	19	parkinson	parkinson	NOUN
gs-3751	111	20	’s	’s	PART
gs-3751	111	21	progression	progression	NOUN
gs-3751	111	22	markers	marker	NOUN
gs-3751	111	23	initiative	initiative	NOUN
gs-3751	111	24	)	)	PUNCT
gs-3751	111	25	and	and	CCONJ
gs-3751	111	26	interventional	interventional	ADJ
gs-3751	111	27	trials	trial	NOUN
gs-3751	111	28	(	(	PUNCT
gs-3751	111	29	probiotics	probiotic	NOUN
gs-3751	111	30	,	,	PUNCT
gs-3751	111	31	fmt	fmt	NOUN
gs-3751	111	32	)	)	PUNCT
gs-3751	111	33	.	.	PUNCT
gs-3751	112	1	case	case	NOUN
gs-3751	112	2	-	-	PUNCT
gs-3751	112	3	control	control	NOUN
gs-3751	112	4	studies	study	NOUN
gs-3751	112	5	comparing	compare	VERB
gs-3751	112	6	ad	ad	NOUN
gs-3751	112	7	/	/	SYM
gs-3751	112	8	pd	pd	NOUN
gs-3751	112	9	patients	patient	NOUN
gs-3751	112	10	to	to	ADP
gs-3751	112	11	age	age	NOUN
gs-3751	112	12	-	-	PUNCT
gs-3751	112	13	matched	match	VERB
gs-3751	112	14	healthy	healthy	ADJ
gs-3751	112	15	controls	control	NOUN
gs-3751	112	16	were	be	AUX
gs-3751	112	17	evaluated	evaluate	VERB
gs-3751	112	18	for	for	ADP
gs-3751	112	19	microbial	microbial	ADJ
gs-3751	112	20	diversity	diversity	NOUN
gs-3751	112	21	(	(	PUNCT
gs-3751	112	22	16s	16	NOUN
gs-3751	112	23	rrna	rrna	VERB
gs-3751	112	24	sequencing	sequence	VERB
gs-3751	112	25	,	,	PUNCT
gs-3751	112	26	metagenomics	metagenomic	NOUN
gs-3751	112	27	)	)	PUNCT
gs-3751	112	28	and	and	CCONJ
gs-3751	112	29	metabolite	metabolite	NOUN
gs-3751	112	30	profiles	profile	NOUN
gs-3751	112	31	(	(	PUNCT
gs-3751	112	32	mass	mass	NOUN
gs-3751	112	33	spectrometry	spectrometry	NOUN
gs-3751	112	34	,	,	PUNCT
gs-3751	112	35	nmr	nmr	NOUN
gs-3751	112	36	)	)	PUNCT
gs-3751	112	37	.	.	PUNCT
gs-3751	113	1			ADJ
gs-3751	113	2	search	search	NOUN
gs-3751	113	3	strategy	strategy	NOUN
gs-3751	113	4	a	a	DET
gs-3751	113	5	literature	literature	NOUN
gs-3751	113	6	search	search	NOUN
gs-3751	113	7	of	of	ADP
gs-3751	113	8	five	five	NUM
gs-3751	113	9	electronic	electronic	ADJ
gs-3751	113	10	databases	database	NOUN
gs-3751	113	11	was	be	AUX
gs-3751	113	12	performed	perform	VERB
gs-3751	113	13	:	:	PUNCT
gs-3751	113	14	pubmed	pubmed	PROPN
gs-3751	113	15	,	,	PUNCT
gs-3751	113	16	embase	embase	PROPN
gs-3751	113	17	,	,	PUNCT
gs-3751	113	18	scopus	scopus	PROPN
gs-3751	113	19	,	,	PUNCT
gs-3751	113	20	cochrane	cochrane	NOUN
gs-3751	113	21	library	library	NOUN
gs-3751	113	22	,	,	PUNCT
gs-3751	113	23	and	and	CCONJ
gs-3751	113	24	google	google	PROPN
gs-3751	113	25	scholar	scholar	NOUN
gs-3751	113	26	.	.	PUNCT
gs-3751	114	1	the	the	DET
gs-3751	114	2	review	review	NOUN
gs-3751	114	3	considered	consider	VERB
gs-3751	114	4	published	publish	VERB
gs-3751	114	5	studies	study	NOUN
gs-3751	114	6	dating	date	VERB
gs-3751	114	7	from	from	ADP
gs-3751	114	8	january	january	PROPN
gs-3751	114	9	2000	2000	NUM
gs-3751	114	10	to	to	ADP
gs-3751	114	11	october	october	PROPN
gs-3751	114	12	2024	2024	NUM
gs-3751	114	13	,	,	PUNCT
gs-3751	114	14	limited	limit	VERB
gs-3751	114	15	to	to	ADP
gs-3751	114	16	english	english	ADJ
gs-3751	114	17	language	language	NOUN
gs-3751	114	18	articles	article	NOUN
gs-3751	114	19	.	.	PUNCT
gs-3751	115	1	the	the	DET
gs-3751	115	2	search	search	NOUN
gs-3751	115	3	terms	term	NOUN
gs-3751	115	4	were	be	AUX
gs-3751	115	5	developed	develop	VERB
gs-3751	115	6	in	in	ADP
gs-3751	115	7	consultation	consultation	NOUN
gs-3751	115	8	georgian	georgian	PROPN
gs-3751	115	9	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3751	115	10	მეცნიერები	მეცნიერები	NOUN
gs-3751	115	11	ტ.	ტ.	VERB
gs-3751	115	12	7	7	NUM
gs-3751	115	13	n	n	DET
gs-3751	115	14	2	2	NUM
gs-3751	115	15	,	,	PUNCT
gs-3751	115	16	2025	2025	NUM
gs-3751	115	17	336	336	NUM
gs-3751	115	18	with	with	ADP
gs-3751	115	19	mesh	mesh	NOUN
gs-3751	115	20	and	and	CCONJ
gs-3751	115	21	the	the	DET
gs-3751	115	22	main	main	ADJ
gs-3751	115	23	keywords	keyword	NOUN
gs-3751	115	24	were	be	AUX
gs-3751	115	25	related	relate	VERB
gs-3751	115	26	to	to	ADP
gs-3751	115	27	the	the	DET
gs-3751	115	28	gut	gut	NOUN
gs-3751	115	29	-	-	PUNCT
gs-3751	115	30	brain	brain	NOUN
gs-3751	115	31	axis	axis	NOUN
gs-3751	115	32	,	,	PUNCT
gs-3751	115	33	microbiome	microbiome	NOUN
gs-3751	115	34	,	,	PUNCT
gs-3751	115	35	and	and	CCONJ
gs-3751	115	36	neurodegenerative	neurodegenerative	ADJ
gs-3751	115	37	diseases	disease	NOUN
gs-3751	115	38	of	of	ADP
gs-3751	115	39	parkinson	parkinson	NOUN
gs-3751	115	40	's	's	PART
gs-3751	115	41	and	and	CCONJ
gs-3751	115	42	alzheimer	alzheimer	NOUN
gs-3751	115	43	's	's	PART
gs-3751	115	44	.	.	PUNCT
gs-3751	116	1	"	"	PUNCT
gs-3751	116	2	gut	gut	NOUN
gs-3751	116	3	-	-	PUNCT
gs-3751	116	4	brain	brain	NOUN
gs-3751	116	5	axis	axis	NOUN
gs-3751	116	6	"	"	PUNCT
gs-3751	116	7	and	and	CCONJ
gs-3751	116	8	"	"	PUNCT
gs-3751	116	9	microbiome	microbiome	NOUN
gs-3751	116	10	"	"	PUNCT
gs-3751	116	11	and	and	CCONJ
gs-3751	116	12	"	"	PUNCT
gs-3751	116	13	parkinson	parkinson	NOUN
gs-3751	116	14	's	's	PART
gs-3751	116	15	disease	disease	NOUN
gs-3751	116	16	"	"	PUNCT
gs-3751	116	17	or	or	CCONJ
gs-3751	116	18	"	"	PUNCT
gs-3751	116	19	alzheimer	alzheimer	PROPN
gs-3751	116	20	's	's	PART
gs-3751	116	21	disease	disease	NOUN
gs-3751	116	22	"	"	PUNCT
gs-3751	116	23	"	"	PUNCT
gs-3751	116	24	microbiome	microbiome	ADJ
gs-3751	116	25	imbalance	imbalance	NOUN
gs-3751	116	26	"	"	PUNCT
gs-3751	116	27	and	and	CCONJ
gs-3751	116	28	"	"	PUNCT
gs-3751	116	29	cognitive	cognitive	ADJ
gs-3751	116	30	decline	decline	NOUN
gs-3751	116	31	"	"	PUNCT
gs-3751	116	32	or	or	CCONJ
gs-3751	116	33	"	"	PUNCT
gs-3751	116	34	brain	brain	NOUN
gs-3751	116	35	function	function	NOUN
gs-3751	116	36	"	"	PUNCT
gs-3751	116	37	"	"	PUNCT
gs-3751	116	38	microbiota	microbiota	NOUN
gs-3751	116	39	therapy	therapy	NOUN
gs-3751	116	40	"	"	PUNCT
gs-3751	116	41	and	and	CCONJ
gs-3751	116	42	"	"	PUNCT
gs-3751	116	43	neurodegenerative	neurodegenerative	ADJ
gs-3751	116	44	diseases	disease	NOUN
gs-3751	116	45			VERB
gs-3751	116	46	eligibility	eligibility	NOUN
gs-3751	116	47	criteria	criterion	NOUN
gs-3751	116	48			NOUN
gs-3751	116	49	inclusion	inclusion	NOUN
gs-3751	116	50	criteria	criterion	NOUN
gs-3751	116	51	population	population	NOUN
gs-3751	116	52	:	:	PUNCT
gs-3751	116	53	population	population	NOUN
gs-3751	116	54	of	of	ADP
gs-3751	116	55	adults	adult	NOUN
gs-3751	116	56	with	with	ADP
gs-3751	116	57	unbalanced	unbalanced	ADJ
gs-3751	116	58	gut	gut	NOUN
gs-3751	116	59	microbiome	microbiome	NOUN
gs-3751	116	60	diagnosed	diagnose	VERB
gs-3751	116	61	with	with	ADP
gs-3751	116	62	or	or	CCONJ
gs-3751	116	63	at	at	ADP
gs-3751	116	64	risk	risk	NOUN
gs-3751	116	65	for	for	ADP
gs-3751	116	66	parkinson	parkinson	NOUN
gs-3751	116	67	's	's	PART
gs-3751	116	68	disease	disease	NOUN
gs-3751	116	69	or	or	CCONJ
gs-3751	116	70	alzheimer	alzheimer	NOUN
gs-3751	116	71	's	's	PART
gs-3751	116	72	disease	disease	NOUN
gs-3751	116	73	.	.	PUNCT
gs-3751	117	1	interventions	intervention	NOUN
gs-3751	117	2	:	:	PUNCT
gs-3751	117	3	studies	study	NOUN
gs-3751	117	4	of	of	ADP
gs-3751	117	5	the	the	DET
gs-3751	117	6	treatments	treatment	NOUN
gs-3751	117	7	targeted	target	VERB
gs-3751	117	8	at	at	ADP
gs-3751	117	9	the	the	DET
gs-3751	117	10	microbiome	microbiome	NOUN
gs-3751	117	11	,	,	PUNCT
gs-3751	117	12	such	such	ADJ
gs-3751	117	13	as	as	ADP
gs-3751	117	14	probiotics	probiotic	NOUN
gs-3751	117	15	,	,	PUNCT
gs-3751	117	16	fecal	fecal	ADJ
gs-3751	117	17	microbiota	microbiota	NOUN
gs-3751	117	18	transplantation	transplantation	NOUN
gs-3751	117	19	,	,	PUNCT
gs-3751	117	20	or	or	CCONJ
gs-3751	117	21	dietary	dietary	ADJ
gs-3751	117	22	interventions	intervention	NOUN
gs-3751	117	23	to	to	PART
gs-3751	117	24	restore	restore	VERB
gs-3751	117	25	gut	gut	NOUN
gs-3751	117	26	balance	balance	NOUN
gs-3751	117	27	.	.	PUNCT
gs-3751	118	1	comparison	comparison	NOUN
gs-3751	118	2	:	:	PUNCT
gs-3751	119	1	comparisons	comparison	NOUN
gs-3751	119	2	of	of	ADP
gs-3751	119	3	microbiome	microbiome	ADJ
gs-3751	119	4	interventions	intervention	NOUN
gs-3751	119	5	with	with	ADP
gs-3751	119	6	no	no	DET
gs-3751	119	7	treatment	treatment	NOUN
gs-3751	119	8	,	,	PUNCT
gs-3751	119	9	placebo	placebo	NOUN
gs-3751	119	10	,	,	PUNCT
gs-3751	119	11	or	or	CCONJ
gs-3751	119	12	standard	standard	ADJ
gs-3751	119	13	care	care	NOUN
gs-3751	119	14	.	.	PUNCT
gs-3751	120	1	outcomes	outcome	NOUN
gs-3751	120	2	:	:	PUNCT
gs-3751	120	3	of	of	ADP
gs-3751	120	4	primary	primary	ADJ
gs-3751	120	5	interest	interest	NOUN
gs-3751	120	6	are	be	AUX
gs-3751	120	7	the	the	DET
gs-3751	120	8	reduced	reduce	VERB
gs-3751	120	9	risk	risk	NOUN
gs-3751	120	10	or	or	CCONJ
gs-3751	120	11	slowing	slowing	NOUN
gs-3751	120	12	of	of	ADP
gs-3751	120	13	disease	disease	NOUN
gs-3751	120	14	progression	progression	NOUN
gs-3751	120	15	of	of	ADP
gs-3751	120	16	either	either	DET
gs-3751	120	17	parkinson	parkinson	NOUN
gs-3751	120	18	's	's	PART
gs-3751	120	19	or	or	CCONJ
gs-3751	120	20	alzheimer	alzheimer	NOUN
gs-3751	120	21	's	's	PART
gs-3751	120	22	disease	disease	NOUN
gs-3751	120	23	.	.	PUNCT
gs-3751	121	1	secondary	secondary	ADJ
gs-3751	121	2	outcomes	outcome	NOUN
gs-3751	121	3	will	will	AUX
gs-3751	121	4	,	,	PUNCT
gs-3751	121	5	therefore	therefore	ADV
gs-3751	121	6	,	,	PUNCT
gs-3751	121	7	include	include	VERB
gs-3751	121	8	changes	change	NOUN
gs-3751	121	9	in	in	ADP
gs-3751	121	10	cognitive	cognitive	ADJ
gs-3751	121	11	function	function	NOUN
gs-3751	121	12	,	,	PUNCT
gs-3751	121	13	microbiome	microbiome	ADJ
gs-3751	121	14	composition	composition	NOUN
gs-3751	121	15	,	,	PUNCT
gs-3751	121	16	and	and	CCONJ
gs-3751	121	17	associated	associate	VERB
gs-3751	121	18	gut	gut	NOUN
gs-3751	121	19	-	-	PUNCT
gs-3751	121	20	brain	brain	NOUN
gs-3751	121	21	axis	axis	NOUN
gs-3751	121	22	dynamics	dynamic	NOUN
gs-3751	121	23	.	.	PUNCT
gs-3751	122	1			ADJ
gs-3751	122	2	study	study	NOUN
gs-3751	122	3	design	design	NOUN
gs-3751	122	4	:	:	PUNCT
gs-3751	122	5	rcts	rct	NOUN
gs-3751	122	6	,	,	PUNCT
gs-3751	122	7	cohort	cohort	NOUN
gs-3751	122	8	studies	study	NOUN
gs-3751	122	9	,	,	PUNCT
gs-3751	122	10	case	case	NOUN
gs-3751	122	11	-	-	PUNCT
gs-3751	122	12	control	control	NOUN
gs-3751	122	13	studies	study	NOUN
gs-3751	122	14	,	,	PUNCT
gs-3751	122	15	and	and	CCONJ
gs-3751	122	16	observational	observational	ADJ
gs-3751	122	17	studies	study	NOUN
gs-3751	122	18			PROPN
gs-3751	122	19	exclusion	exclusion	NOUN
gs-3751	122	20	criteria	criteria	VERB
gs-3751	122	21	the	the	DET
gs-3751	122	22	nature	nature	NOUN
gs-3751	122	23	of	of	ADP
gs-3751	122	24	the	the	DET
gs-3751	122	25	review	review	NOUN
gs-3751	122	26	focus	focus	VERB
gs-3751	122	27	on	on	ADP
gs-3751	122	28	:	:	PUNCT
gs-3751	122	29			NOUN
gs-3751	122	30	animal	animal	NOUN
gs-3751	122	31	models	model	NOUN
gs-3751	122	32	or	or	CCONJ
gs-3751	122	33	test	test	NOUN
gs-3751	122	34	tube	tube	NOUN
gs-3751	122	35	experiments	experiment	NOUN
gs-3751	122	36			NOUN
gs-3751	122	37	pediatric	pediatric	ADJ
gs-3751	122	38	populations	population	NOUN
gs-3751	122	39			PRON
gs-3751	122	40	non	non	ADJ
gs-3751	122	41	-	-	ADJ
gs-3751	122	42	neurodegenerative	neurodegenerative	ADJ
gs-3751	122	43	disorders	disorder	NOUN
gs-3751	122	44			NOUN
gs-3751	122	45	articles	article	NOUN
gs-3751	122	46	for	for	ADP
gs-3751	122	47	which	which	PRON
gs-3751	122	48	full	full	ADJ
gs-3751	122	49	text	text	NOUN
gs-3751	122	50	was	be	AUX
gs-3751	122	51	unavailable	unavailable	ADJ
gs-3751	122	52	and/or	and/or	CCONJ
gs-3751	122	53	data	datum	NOUN
gs-3751	122	54	incomplete	incomplete	ADJ
gs-3751	122	55	and	and	CCONJ
gs-3751	122	56	unpublished	unpublished	ADJ
gs-3751	122	57	/	/	SYM
gs-3751	122	58	non	non	ADJ
gs-3751	122	59	-	-	ADJ
gs-3751	122	60	peerreviewed	peerreviewed	ADJ
gs-3751	122	61	sources	source	NOUN
gs-3751	122	62	.	.	PUNCT
gs-3751	123	1			ADJ
gs-3751	123	2	data	datum	NOUN
gs-3751	123	3	extraction	extraction	NOUN
gs-3751	123	4	process	process	NOUN
gs-3751	123	5	data	data	NOUN
gs-3751	123	6	extraction	extraction	NOUN
gs-3751	123	7	was	be	AUX
gs-3751	123	8	conducted	conduct	VERB
gs-3751	123	9	by	by	ADP
gs-3751	123	10	authors	author	NOUN
gs-3751	123	11	applying	apply	VERB
gs-3751	123	12	a	a	DET
gs-3751	123	13	standardized	standardized	ADJ
gs-3751	123	14	form	form	NOUN
gs-3751	123	15	.	.	PUNCT
gs-3751	124	1	collected	collect	VERB
gs-3751	124	2	data	datum	NOUN
gs-3751	124	3	included	include	VERB
gs-3751	124	4	the	the	DET
gs-3751	124	5	following	follow	VERB
gs-3751	124	6	study	study	NOUN
gs-3751	124	7	characteristics	characteristic	NOUN
gs-3751	124	8	:	:	PUNCT
gs-3751	124	9	author	author	NOUN
gs-3751	124	10	,	,	PUNCT
gs-3751	124	11	publication	publication	NOUN
gs-3751	124	12	year	year	NOUN
gs-3751	124	13	,	,	PUNCT
gs-3751	124	14	country	country	NOUN
gs-3751	124	15	,	,	PUNCT
gs-3751	124	16	study	study	NOUN
gs-3751	124	17	design	design	NOUN
gs-3751	124	18	;	;	PUNCT
gs-3751	124	19	population	population	NOUN
gs-3751	124	20	characteristics	characteristic	NOUN
gs-3751	124	21	:	:	PUNCT
gs-3751	124	22	sample	sample	NOUN
gs-3751	124	23	size	size	NOUN
gs-3751	124	24	,	,	PUNCT
gs-3751	124	25	age	age	NOUN
gs-3751	124	26	,	,	PUNCT
gs-3751	124	27	gender	gender	NOUN
gs-3751	124	28	,	,	PUNCT
gs-3751	124	29	and	and	CCONJ
gs-3751	124	30	clinical	clinical	ADJ
gs-3751	124	31	diagnoses	diagnosis	NOUN
gs-3751	124	32	;	;	PUNCT
gs-3751	124	33	intervention	intervention	NOUN
gs-3751	124	34	details	detail	NOUN
gs-3751	124	35	:	:	PUNCT
gs-3751	124	36	type	type	NOUN
gs-3751	124	37	of	of	ADP
gs-3751	124	38	microbiome	microbiome	NOUN
gs-3751	124	39	intervention	intervention	NOUN
gs-3751	124	40	,	,	PUNCT
gs-3751	124	41	dosage	dosage	NOUN
gs-3751	124	42	,	,	PUNCT
gs-3751	124	43	and	and	CCONJ
gs-3751	124	44	duration	duration	NOUN
gs-3751	124	45	;	;	PUNCT
gs-3751	124	46	outcomes	outcome	NOUN
gs-3751	124	47	:	:	PUNCT
gs-3751	124	48	primary	primary	ADJ
gs-3751	124	49	outcomes	outcome	NOUN
gs-3751	124	50	include	include	VERB
gs-3751	124	51	risk	risk	NOUN
gs-3751	124	52	reduction	reduction	NOUN
gs-3751	124	53	,	,	PUNCT
gs-3751	124	54	and	and	CCONJ
gs-3751	124	55	disease	disease	NOUN
gs-3751	124	56	progression	progression	NOUN
gs-3751	124	57	;	;	PUNCT
gs-3751	124	58	secondary	secondary	ADJ
gs-3751	124	59	outcomes	outcome	NOUN
gs-3751	124	60	include	include	VERB
gs-3751	124	61	cognitive	cognitive	ADJ
gs-3751	124	62	assessment	assessment	NOUN
gs-3751	124	63	and	and	CCONJ
gs-3751	124	64	microbiome	microbiome	ADJ
gs-3751	124	65	changes	change	NOUN
gs-3751	124	66	;	;	PUNCT
gs-3751	124	67	and	and	CCONJ
gs-3751	124	68	finally	finally	ADV
gs-3751	124	69	,	,	PUNCT
gs-3751	124	70	the	the	DET
gs-3751	124	71	risk	risk	NOUN
gs-3751	124	72	of	of	ADP
gs-3751	124	73	bias	bias	NOUN
gs-3751	124	74	,	,	PUNCT
gs-3751	124	75	based	base	VERB
gs-3751	124	76	on	on	ADP
gs-3751	124	77	blinding	blind	VERB
gs-3751	124	78	,	,	PUNCT
gs-3751	124	79	randomization	randomization	NOUN
gs-3751	124	80	,	,	PUNCT
gs-3751	124	81	and	and	CCONJ
gs-3751	124	82	completeness	completeness	NOUN
gs-3751	124	83	of	of	ADP
gs-3751	124	84	outcome	outcome	NOUN
gs-3751	124	85	reporting	reporting	NOUN
gs-3751	124	86	.	.	PUNCT
gs-3751	125	1	any	any	DET
gs-3751	125	2	discrepancies	discrepancy	NOUN
gs-3751	125	3	between	between	ADP
gs-3751	125	4	the	the	DET
gs-3751	125	5	reviewers	reviewer	NOUN
gs-3751	125	6	were	be	AUX
gs-3751	125	7	resolved	resolve	VERB
gs-3751	125	8	through	through	ADP
gs-3751	125	9	discussion	discussion	NOUN
gs-3751	125	10	.	.	PUNCT
gs-3751	126	1			ADJ
gs-3751	126	2	risk	risk	NOUN
gs-3751	126	3	of	of	ADP
gs-3751	126	4	bias	bias	NOUN
gs-3751	126	5	assessment	assessment	NOUN
gs-3751	126	6	the	the	DET
gs-3751	126	7	cochrane	cochrane	NOUN
gs-3751	126	8	risk	risk	NOUN
gs-3751	126	9	of	of	ADP
gs-3751	126	10	bias	bias	NOUN
gs-3751	126	11	tool	tool	NOUN
gs-3751	126	12	was	be	AUX
gs-3751	126	13	used	use	VERB
gs-3751	126	14	to	to	PART
gs-3751	126	15	assess	assess	VERB
gs-3751	126	16	the	the	DET
gs-3751	126	17	risk	risk	NOUN
gs-3751	126	18	of	of	ADP
gs-3751	126	19	bias	bias	NOUN
gs-3751	126	20	for	for	ADP
gs-3751	126	21	all	all	DET
gs-3751	126	22	rcts	rct	NOUN
gs-3751	126	23	included	include	VERB
gs-3751	126	24	in	in	ADP
gs-3751	126	25	the	the	DET
gs-3751	126	26	study	study	NOUN
gs-3751	126	27	,	,	PUNCT
gs-3751	126	28	while	while	SCONJ
gs-3751	126	29	robins	robin	NOUN
gs-3751	126	30	-	-	PUNCT
gs-3751	126	31	i	i	PRON
gs-3751	126	32	(	(	PUNCT
gs-3751	126	33	risk	risk	NOUN
gs-3751	126	34	of	of	ADP
gs-3751	126	35	bias	bias	NOUN
gs-3751	126	36	in	in	ADP
gs-3751	126	37	nonrandomized	nonrandomize	VERB
gs-3751	126	38	studies	study	NOUN
gs-3751	126	39	-	-	PUNCT
gs-3751	126	40	of	of	ADP
gs-3751	126	41	interventions	intervention	NOUN
gs-3751	126	42	)	)	PUNCT
gs-3751	126	43	was	be	AUX
gs-3751	126	44	utilized	utilize	VERB
gs-3751	126	45	for	for	ADP
gs-3751	126	46	the	the	DET
gs-3751	126	47	nonrandomized	nonrandomize	VERB
gs-3751	126	48	.	.	PUNCT
gs-3751	127	1	each	each	DET
gs-3751	127	2	study	study	NOUN
gs-3751	127	3	was	be	AUX
gs-3751	127	4	analyzed	analyze	VERB
gs-3751	127	5	for	for	ADP
gs-3751	127	6	several	several	ADJ
gs-3751	127	7	domains	domain	NOUN
gs-3751	127	8	including	include	VERB
gs-3751	127	9	:	:	PUNCT
gs-3751	127	10			NOUN
gs-3751	127	11	selection	selection	NOUN
gs-3751	127	12	bias	bias	NOUN
gs-3751	127	13	:	:	PUNCT
gs-3751	127	14	sufficiency	sufficiency	NOUN
gs-3751	127	15	of	of	ADP
gs-3751	127	16	randomization	randomization	NOUN
gs-3751	127	17	and	and	CCONJ
gs-3751	127	18	allocation	allocation	NOUN
gs-3751	127	19	concealment	concealment	NOUN
gs-3751	127	20	.	.	PUNCT
gs-3751	128	1			NOUN
gs-3751	128	2	performance	performance	NOUN
gs-3751	128	3	bias	bias	NOUN
gs-3751	128	4	:	:	PUNCT
gs-3751	128	5	blinding	blinding	NOUN
gs-3751	128	6	of	of	ADP
gs-3751	128	7	participants	participant	NOUN
gs-3751	128	8	and	and	CCONJ
gs-3751	128	9	personnel	personnel	NOUN
gs-3751	128	10	.	.	PUNCT
gs-3751	129	1			NOUN
gs-3751	129	2	detection	detection	NOUN
gs-3751	129	3	bias	bias	NOUN
gs-3751	129	4	:	:	PUNCT
gs-3751	129	5	blinding	blind	VERB
gs-3751	129	6	of	of	ADP
gs-3751	129	7	outcome	outcome	NOUN
gs-3751	129	8	assessment	assessment	NOUN
gs-3751	129	9	.	.	PUNCT
gs-3751	130	1	georgian	georgian	ADJ
gs-3751	130	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3751	130	3	მეცნიერები	მეცნიერები	NOUN
gs-3751	130	4	ტ.	ტ.	VERB
gs-3751	130	5	7	7	NUM
gs-3751	130	6	n	n	DET
gs-3751	130	7	2	2	NUM
gs-3751	130	8	,	,	PUNCT
gs-3751	130	9	2025	2025	NUM
gs-3751	130	10	337	337	NUM
gs-3751	130	11			NOUN
gs-3751	130	12	attrition	attrition	NOUN
gs-3751	130	13	bias	bias	NOUN
gs-3751	130	14	:	:	PUNCT
gs-3751	130	15	completeness	completeness	NOUN
gs-3751	130	16	of	of	ADP
gs-3751	130	17	outcome	outcome	NOUN
gs-3751	130	18	data	datum	NOUN
gs-3751	130	19	.	.	PUNCT
gs-3751	131	1			NOUN
gs-3751	131	2	reporting	report	VERB
gs-3751	131	3	bias	bias	NOUN
gs-3751	131	4	:	:	PUNCT
gs-3751	131	5	selective	selective	ADJ
gs-3751	131	6	reporting	reporting	NOUN
gs-3751	131	7	of	of	ADP
gs-3751	131	8	results	result	NOUN
gs-3751	131	9	.	.	PUNCT
gs-3751	132	1	when	when	SCONJ
gs-3751	132	2	meta	meta	X
gs-3751	132	3	-	-	PUNCT
gs-3751	132	4	analysis	analysis	NOUN
gs-3751	132	5	could	could	AUX
gs-3751	132	6	not	not	PART
gs-3751	132	7	be	be	AUX
gs-3751	132	8	performed	perform	VERB
gs-3751	132	9	due	due	ADP
gs-3751	132	10	to	to	ADP
gs-3751	132	11	the	the	DET
gs-3751	132	12	heterogeneity	heterogeneity	NOUN
gs-3751	132	13	of	of	ADP
gs-3751	132	14	interventions	intervention	NOUN
gs-3751	132	15	or	or	CCONJ
gs-3751	132	16	the	the	DET
gs-3751	132	17	measured	measured	ADJ
gs-3751	132	18	outcomes	outcome	NOUN
gs-3751	132	19	,	,	PUNCT
gs-3751	132	20	a	a	DET
gs-3751	132	21	narrative	narrative	ADJ
gs-3751	132	22	synthesis	synthesis	NOUN
gs-3751	132	23	was	be	AUX
gs-3751	132	24	carried	carry	VERB
gs-3751	132	25	out	out	ADP
gs-3751	132	26	,	,	PUNCT
gs-3751	132	27	describing	describe	VERB
gs-3751	132	28	the	the	DET
gs-3751	132	29	key	key	ADJ
gs-3751	132	30	findings	finding	NOUN
gs-3751	132	31	and	and	CCONJ
gs-3751	132	32	the	the	DET
gs-3751	132	33	general	general	ADJ
gs-3751	132	34	trend	trend	NOUN
gs-3751	132	35	of	of	ADP
gs-3751	132	36	the	the	DET
gs-3751	132	37	literature	literature	NOUN
gs-3751	132	38	findings	finding	NOUN
gs-3751	132	39	.	.	PUNCT
gs-3751	133	1			ADJ
gs-3751	133	2	ethical	ethical	ADJ
gs-3751	133	3	considerations	consideration	NOUN
gs-3751	133	4	:	:	PUNCT
gs-3751	133	5	human	human	ADJ
gs-3751	133	6	studies	study	NOUN
gs-3751	133	7	adhered	adhere	VERB
gs-3751	133	8	to	to	ADP
gs-3751	133	9	declaration	declaration	NOUN
gs-3751	133	10	of	of	ADP
gs-3751	133	11	helsinki	helsinki	PROPN
gs-3751	133	12	principles	principle	NOUN
gs-3751	133	13	,	,	PUNCT
gs-3751	133	14	with	with	ADP
gs-3751	133	15	protocols	protocol	NOUN
gs-3751	133	16	approved	approve	VERB
gs-3751	133	17	by	by	ADP
gs-3751	133	18	institutional	institutional	ADJ
gs-3751	133	19	review	review	NOUN
gs-3751	133	20	boards	board	NOUN
gs-3751	133	21	(	(	PUNCT
gs-3751	133	22	irbs	irb	NOUN
gs-3751	133	23	)	)	PUNCT
gs-3751	133	24	.	.	PUNCT
gs-3751	134	1	animal	animal	NOUN
gs-3751	134	2	experiments	experiment	NOUN
gs-3751	134	3	followed	follow	VERB
gs-3751	134	4	arrive	arrive	ADJ
gs-3751	134	5	guidelines	guideline	NOUN
gs-3751	134	6	,	,	PUNCT
gs-3751	134	7	with	with	ADP
gs-3751	134	8	ethical	ethical	ADJ
gs-3751	134	9	oversight	oversight	NOUN
gs-3751	134	10	for	for	ADP
gs-3751	134	11	humane	humane	ADJ
gs-3751	134	12	endpoints	endpoint	NOUN
gs-3751	134	13	.	.	PUNCT
gs-3751	135	1	results	result	NOUN
gs-3751	135	2	and	and	CCONJ
gs-3751	135	3	discussion	discussion	NOUN
gs-3751	135	4			VERB
gs-3751	135	5	the	the	DET
gs-3751	135	6	gut	gut	NOUN
gs-3751	135	7	-	-	PUNCT
gs-3751	135	8	brain	brain	NOUN
gs-3751	135	9	axis	axis	NOUN
gs-3751	135	10	:	:	PUNCT
gs-3751	135	11	mechanisms	mechanism	NOUN
gs-3751	135	12	of	of	ADP
gs-3751	135	13	communication	communication	NOUN
gs-3751	135	14	the	the	DET
gs-3751	135	15	gut	gut	NOUN
gs-3751	135	16	-	-	PUNCT
gs-3751	135	17	brain	brain	NOUN
gs-3751	135	18	axis	axis	NOUN
gs-3751	135	19	(	(	PUNCT
gs-3751	135	20	gba	gba	NOUN
gs-3751	135	21	)	)	PUNCT
gs-3751	135	22	operates	operate	VERB
gs-3751	135	23	through	through	ADP
gs-3751	135	24	a	a	DET
gs-3751	135	25	sophisticated	sophisticated	ADJ
gs-3751	135	26	interplay	interplay	NOUN
gs-3751	135	27	of	of	ADP
gs-3751	135	28	neural	neural	ADJ
gs-3751	135	29	,	,	PUNCT
gs-3751	135	30	endocrine	endocrine	NOUN
gs-3751	135	31	,	,	PUNCT
gs-3751	135	32	immune	immune	NOUN
gs-3751	135	33	,	,	PUNCT
gs-3751	135	34	and	and	CCONJ
gs-3751	135	35	metabolic	metabolic	NOUN
gs-3751	135	36	pathways	pathway	NOUN
gs-3751	135	37	.	.	PUNCT
gs-3751	136	1	beyond	beyond	ADP
gs-3751	136	2	the	the	DET
gs-3751	136	3	well	well	ADV
gs-3751	136	4	-	-	PUNCT
gs-3751	136	5	characterized	characterize	VERB
gs-3751	136	6	vagus	vagus	NOUN
gs-3751	136	7	nerve	nerve	NOUN
gs-3751	136	8	,	,	PUNCT
gs-3751	136	9	recent	recent	ADJ
gs-3751	136	10	studies	study	NOUN
gs-3751	136	11	highlight	highlight	VERB
gs-3751	136	12	the	the	DET
gs-3751	136	13	role	role	NOUN
gs-3751	136	14	of	of	ADP
gs-3751	136	15	the	the	DET
gs-3751	136	16	hypothalamic	hypothalamic	ADJ
gs-3751	136	17	-	-	PUNCT
gs-3751	136	18	pituitary	pituitary	ADJ
gs-3751	136	19	-	-	PUNCT
gs-3751	136	20	adrenal	adrenal	ADJ
gs-3751	136	21	(	(	PUNCT
gs-3751	136	22	hpa	hpa	NOUN
gs-3751	136	23	)	)	PUNCT
gs-3751	136	24	axis	axis	NOUN
gs-3751	136	25	in	in	ADP
gs-3751	136	26	mediating	mediate	VERB
gs-3751	136	27	stress	stress	NOUN
gs-3751	136	28	responses	response	NOUN
gs-3751	136	29	via	via	ADP
gs-3751	136	30	cortisol	cortisol	NOUN
gs-3751	136	31	release	release	NOUN
gs-3751	136	32	,	,	PUNCT
gs-3751	136	33	which	which	PRON
gs-3751	136	34	directly	directly	ADV
gs-3751	136	35	alters	alter	VERB
gs-3751	136	36	gut	gut	NOUN
gs-3751	136	37	permeability	permeability	NOUN
gs-3751	136	38	and	and	CCONJ
gs-3751	136	39	microbial	microbial	ADJ
gs-3751	136	40	composition	composition	NOUN
gs-3751	136	41	.	.	PUNCT
gs-3751	137	1	for	for	ADP
gs-3751	137	2	example	example	NOUN
gs-3751	137	3	,	,	PUNCT
gs-3751	137	4	chronic	chronic	ADJ
gs-3751	137	5	stress	stress	NOUN
gs-3751	137	6	in	in	ADP
gs-3751	137	7	rodent	rodent	NOUN
gs-3751	137	8	models	model	NOUN
gs-3751	137	9	reduces	reduce	VERB
gs-3751	137	10	lactobacillus	lactobacillus	NOUN
gs-3751	137	11	populations	population	NOUN
gs-3751	137	12	,	,	PUNCT
gs-3751	137	13	increasing	increase	VERB
gs-3751	137	14	intestinal	intestinal	ADJ
gs-3751	137	15	permeability	permeability	NOUN
gs-3751	137	16	and	and	CCONJ
gs-3751	137	17	allowing	allow	VERB
gs-3751	137	18	bacterial	bacterial	ADJ
gs-3751	137	19	endotoxins	endotoxin	NOUN
gs-3751	137	20	like	like	ADP
gs-3751	137	21	lipopolysaccharide	lipopolysaccharide	ADV
gs-3751	137	22	(	(	PUNCT
gs-3751	137	23	lps	lps	PROPN
gs-3751	137	24	)	)	PUNCT
gs-3751	137	25	to	to	PART
gs-3751	137	26	enter	enter	VERB
gs-3751	137	27	systemic	systemic	ADJ
gs-3751	137	28	circulation	circulation	NOUN
gs-3751	137	29	.	.	PUNCT
gs-3751	138	1	this	this	PRON
gs-3751	138	2	triggers	trigger	VERB
gs-3751	138	3	neuroinflammation	neuroinflammation	NOUN
gs-3751	138	4	by	by	ADP
gs-3751	138	5	activating	activate	VERB
gs-3751	138	6	toll	toll	NOUN
gs-3751	138	7	-	-	PUNCT
gs-3751	138	8	like	like	ADJ
gs-3751	138	9	receptor	receptor	NOUN
gs-3751	138	10	(	(	PUNCT
gs-3751	138	11	tlr	tlr	PROPN
gs-3751	138	12	)	)	PUNCT
gs-3751	138	13	on	on	ADP
gs-3751	138	14	microglia	microglia	NOUN
gs-3751	138	15	,	,	PUNCT
gs-3751	138	16	leading	lead	VERB
gs-3751	138	17	to	to	ADP
gs-3751	138	18	cytokine	cytokine	VERB
gs-3751	138	19	storms	storm	NOUN
gs-3751	138	20	implicated	implicate	VERB
gs-3751	138	21	in	in	ADP
gs-3751	138	22	alzheimer	alzheimer	PROPN
gs-3751	138	23	’s	’s	PART
gs-3751	138	24	disease	disease	NOUN
gs-3751	138	25	(	(	PUNCT
gs-3751	138	26	ad	ad	NOUN
gs-3751	138	27	)	)	PUNCT
gs-3751	138	28	and	and	CCONJ
gs-3751	138	29	parkinson	parkinson	NOUN
gs-3751	138	30	’s	’s	PART
gs-3751	138	31	disease	disease	NOUN
gs-3751	138	32	(	(	PUNCT
gs-3751	138	33	pd	pd	NOUN
gs-3751	138	34	)	)	PUNCT
gs-3751	138	35	.	.	PUNCT
gs-3751	139	1	the	the	DET
gs-3751	139	2	enteric	enteric	ADJ
gs-3751	139	3	nervous	nervous	ADJ
gs-3751	139	4	system	system	NOUN
gs-3751	139	5	(	(	PUNCT
gs-3751	139	6	ens	ens	PROPN
gs-3751	139	7	)	)	PUNCT
gs-3751	139	8	,	,	PUNCT
gs-3751	139	9	often	often	ADV
gs-3751	139	10	termed	term	VERB
gs-3751	139	11	the	the	DET
gs-3751	139	12	"	"	PUNCT
gs-3751	139	13	second	second	ADJ
gs-3751	139	14	brain	brain	NOUN
gs-3751	139	15	,	,	PUNCT
gs-3751	139	16	"	"	PUNCT
gs-3751	139	17	contains	contain	VERB
gs-3751	139	18	500	500	NUM
gs-3751	139	19	million	million	NUM
gs-3751	139	20	neurons	neuron	NOUN
gs-3751	139	21	that	that	PRON
gs-3751	139	22	autonomously	autonomously	ADV
gs-3751	139	23	regulate	regulate	VERB
gs-3751	139	24	gut	gut	NOUN
gs-3751	139	25	motility	motility	NOUN
gs-3751	139	26	and	and	CCONJ
gs-3751	139	27	secretion	secretion	NOUN
gs-3751	139	28	.	.	PUNCT
gs-3751	140	1	these	these	DET
gs-3751	140	2	neurons	neuron	NOUN
gs-3751	140	3	produce	produce	VERB
gs-3751	140	4	neurotransmitters	neurotransmitter	NOUN
gs-3751	140	5	identical	identical	ADJ
gs-3751	140	6	to	to	ADP
gs-3751	140	7	those	those	PRON
gs-3751	140	8	in	in	ADP
gs-3751	140	9	the	the	DET
gs-3751	140	10	cns	cns	NOUN
gs-3751	140	11	,	,	PUNCT
gs-3751	140	12	including	include	VERB
gs-3751	140	13	90	90	NUM
gs-3751	140	14	%	%	NOUN
gs-3751	140	15	of	of	ADP
gs-3751	140	16	the	the	DET
gs-3751	140	17	body	body	NOUN
gs-3751	140	18	’s	’s	PART
gs-3751	140	19	serotonin	serotonin	NOUN
gs-3751	140	20	(	(	PUNCT
gs-3751	140	21	synthesized	synthesize	VERB
gs-3751	140	22	by	by	ADP
gs-3751	140	23	enterochromaffin	enterochromaffin	NOUN
gs-3751	140	24	cells	cell	NOUN
gs-3751	140	25	)	)	PUNCT
gs-3751	140	26	.	.	PUNCT
gs-3751	141	1	dysregulation	dysregulation	NOUN
gs-3751	141	2	of	of	ADP
gs-3751	141	3	gut	gut	NOUN
gs-3751	141	4	-	-	PUNCT
gs-3751	141	5	derived	derive	VERB
gs-3751	141	6	serotonin	serotonin	NOUN
gs-3751	141	7	has	have	AUX
gs-3751	141	8	been	be	AUX
gs-3751	141	9	linked	link	VERB
gs-3751	141	10	to	to	ADP
gs-3751	141	11	amyloid	amyloid	NOUN
gs-3751	141	12	-	-	PUNCT
gs-3751	141	13	beta	beta	NOUN
gs-3751	141	14	(	(	PUNCT
gs-3751	141	15	aβ	aβ	NOUN
gs-3751	141	16	)	)	PUNCT
gs-3751	141	17	accumulation	accumulation	NOUN
gs-3751	141	18	in	in	ADP
gs-3751	141	19	ad	ad	NOUN
gs-3751	141	20	,	,	PUNCT
gs-3751	141	21	as	as	SCONJ
gs-3751	141	22	serotonin	serotonin	NOUN
gs-3751	141	23	receptors	receptor	NOUN
gs-3751	141	24	(	(	PUNCT
gs-3751	141	25	e.g.	e.g.	ADV
gs-3751	141	26	,	,	PUNCT
gs-3751	141	27	5	5	NUM
gs-3751	141	28	-	-	PUNCT
gs-3751	141	29	ht4r	ht4r	NOUN
gs-3751	141	30	)	)	PUNCT
gs-3751	141	31	modulate	modulate	VERB
gs-3751	141	32	aβ	aβ	DET
gs-3751	141	33	clearance	clearance	NOUN
gs-3751	141	34	via	via	ADP
gs-3751	141	35	the	the	DET
gs-3751	141	36	glymphatic	glymphatic	ADJ
gs-3751	141	37	system	system	NOUN
gs-3751	141	38	.	.	PUNCT
gs-3751	142	1	conversely	conversely	ADV
gs-3751	142	2	,	,	PUNCT
gs-3751	142	3	dopamine	dopamine	NOUN
gs-3751	142	4	produced	produce	VERB
gs-3751	142	5	by	by	ADP
gs-3751	142	6	lactobacillus	lactobacillus	NOUN
gs-3751	142	7	and	and	CCONJ
gs-3751	142	8	bifidobacterium	bifidobacterium	NOUN
gs-3751	142	9	species	specie	NOUN
gs-3751	142	10	influences	influence	VERB
gs-3751	142	11	pd	pd	PROPN
gs-3751	142	12	pathology	pathology	NOUN
gs-3751	142	13	,	,	PUNCT
gs-3751	142	14	as	as	SCONJ
gs-3751	142	15	dopaminergic	dopaminergic	ADJ
gs-3751	142	16	neuron	neuron	NOUN
gs-3751	142	17	loss	loss	NOUN
gs-3751	142	18	in	in	ADP
gs-3751	142	19	the	the	DET
gs-3751	142	20	substantia	substantia	NOUN
gs-3751	142	21	nigra	nigra	PROPN
gs-3751	142	22	correlates	correlate	VERB
gs-3751	142	23	with	with	ADP
gs-3751	142	24	reduced	reduced	ADJ
gs-3751	142	25	gut	gut	NOUN
gs-3751	142	26	microbial	microbial	ADJ
gs-3751	142	27	diversity	diversity	NOUN
gs-3751	142	28	.	.	PUNCT
gs-3751	143	1	emerging	emerge	VERB
gs-3751	143	2	evidence	evidence	NOUN
gs-3751	143	3	implicates	implicate	VERB
gs-3751	143	4	microbial	microbial	ADJ
gs-3751	143	5	metabolites	metabolite	NOUN
gs-3751	143	6	as	as	ADP
gs-3751	143	7	key	key	ADJ
gs-3751	143	8	mediators	mediator	NOUN
gs-3751	143	9	of	of	ADP
gs-3751	143	10	gba	gba	NOUN
gs-3751	143	11	crosstalk	crosstalk	NOUN
gs-3751	143	12	.	.	PUNCT
gs-3751	144	1	shortchain	shortchain	NOUN
gs-3751	144	2	fatty	fatty	NOUN
gs-3751	144	3	acids	acid	NOUN
gs-3751	144	4	(	(	PUNCT
gs-3751	144	5	scfas	scfas	NOUN
gs-3751	144	6	)	)	PUNCT
gs-3751	144	7	,	,	PUNCT
gs-3751	144	8	such	such	ADJ
gs-3751	144	9	as	as	ADP
gs-3751	144	10	butyrate	butyrate	NOUN
gs-3751	144	11	,	,	PUNCT
gs-3751	144	12	propionate	propionate	NOUN
gs-3751	144	13	,	,	PUNCT
gs-3751	144	14	and	and	CCONJ
gs-3751	144	15	acetate	acetate	NOUN
gs-3751	144	16	,	,	PUNCT
gs-3751	144	17	are	be	AUX
gs-3751	144	18	produced	produce	VERB
gs-3751	144	19	by	by	ADP
gs-3751	144	20	bacterial	bacterial	ADJ
gs-3751	144	21	fermentation	fermentation	NOUN
gs-3751	144	22	of	of	ADP
gs-3751	144	23	dietary	dietary	ADJ
gs-3751	144	24	fiber	fiber	NOUN
gs-3751	144	25	.	.	PUNCT
gs-3751	145	1	butyrate	butyrate	NOUN
gs-3751	145	2	enhances	enhance	VERB
gs-3751	145	3	blood	blood	NOUN
gs-3751	145	4	-	-	PUNCT
gs-3751	145	5	brain	brain	NOUN
gs-3751	145	6	barrier	barrier	NOUN
gs-3751	145	7	(	(	PUNCT
gs-3751	145	8	bbb	bbb	NOUN
gs-3751	145	9	)	)	PUNCT
gs-3751	145	10	integrity	integrity	NOUN
gs-3751	145	11	by	by	ADP
gs-3751	145	12	upregulating	upregulating	ADJ
gs-3751	145	13	tight	tight	ADJ
gs-3751	145	14	junction	junction	NOUN
gs-3751	145	15	proteins	protein	NOUN
gs-3751	145	16	(	(	PUNCT
gs-3751	145	17	e.g.	e.g.	ADV
gs-3751	145	18	,	,	PUNCT
gs-3751	145	19	claudin-5	claudin-5	NOUN
gs-3751	145	20	)	)	PUNCT
gs-3751	145	21	and	and	CCONJ
gs-3751	145	22	suppresses	suppress	VERB
gs-3751	145	23	neuroinflammation	neuroinflammation	NOUN
gs-3751	145	24	via	via	ADP
gs-3751	145	25	histone	histone	PROPN
gs-3751	145	26	deacetylase	deacetylase	PROPN
gs-3751	145	27	(	(	PUNCT
gs-3751	145	28	hdac	hdac	NOUN
gs-3751	145	29	)	)	PUNCT
gs-3751	145	30	inhibition	inhibition	NOUN
gs-3751	145	31	.	.	PUNCT
gs-3751	146	1	in	in	ADP
gs-3751	146	2	contrast	contrast	NOUN
gs-3751	146	3	,	,	PUNCT
gs-3751	146	4	trimethylamine	trimethylamine	NOUN
gs-3751	146	5	n	n	CCONJ
gs-3751	146	6	-	-	PUNCT
gs-3751	146	7	oxide	oxide	NOUN
gs-3751	146	8	(	(	PUNCT
gs-3751	146	9	tmao	tmao	PROPN
gs-3751	146	10	)	)	PUNCT
gs-3751	146	11	,	,	PUNCT
gs-3751	146	12	derived	derive	VERB
gs-3751	146	13	from	from	ADP
gs-3751	146	14	red	red	ADJ
gs-3751	146	15	meat	meat	NOUN
gs-3751	146	16	and	and	CCONJ
gs-3751	146	17	eggs	egg	NOUN
gs-3751	146	18	,	,	PUNCT
gs-3751	146	19	promotes	promote	VERB
gs-3751	146	20	bbb	bbb	NOUN
gs-3751	146	21	leakage	leakage	NOUN
gs-3751	146	22	by	by	ADP
gs-3751	146	23	activating	activate	VERB
gs-3751	146	24	the	the	DET
gs-3751	146	25	nlrp3	nlrp3	ADJ
gs-3751	146	26	inflammasome	inflammasome	NOUN
gs-3751	146	27	in	in	ADP
gs-3751	146	28	endothelial	endothelial	ADJ
gs-3751	146	29	cells	cell	NOUN
gs-3751	146	30	.	.	PUNCT
gs-3751	147	1	the	the	DET
gs-3751	147	2	individuals	individual	NOUN
gs-3751	147	3	with	with	ADP
gs-3751	147	4	tmao	tmao	PROPN
gs-3751	147	5	levels	level	NOUN
gs-3751	147	6	in	in	ADP
gs-3751	147	7	the	the	DET
gs-3751	147	8	top	top	ADJ
gs-3751	147	9	quartile	quartile	NOUN
gs-3751	147	10	had	have	VERB
gs-3751	147	11	a	a	DET
gs-3751	147	12	3.2	3.2	NUM
gs-3751	147	13	-	-	ADJ
gs-3751	147	14	fold	fold	ADJ
gs-3751	147	15	higher	high	ADJ
gs-3751	147	16	risk	risk	NOUN
gs-3751	147	17	of	of	ADP
gs-3751	147	18	ad	ad	NOUN
gs-3751	147	19	over	over	ADP
gs-3751	147	20	five	five	NUM
gs-3751	147	21	years	year	NOUN
gs-3751	147	22	,	,	PUNCT
gs-3751	147	23	independent	independent	ADJ
gs-3751	147	24	of	of	ADP
gs-3751	147	25	apoe4	apoe4	PROPN
gs-3751	147	26	status	status	NOUN
gs-3751	147	27	.	.	PUNCT
gs-3751	148	1	the	the	DET
gs-3751	148	2	gut	gut	NOUN
gs-3751	148	3	-	-	PUNCT
gs-3751	148	4	brain	brain	NOUN
gs-3751	148	5	axis	axis	NOUN
gs-3751	148	6	(	(	PUNCT
gs-3751	148	7	gba	gba	NOUN
gs-3751	148	8	)	)	PUNCT
gs-3751	148	9	represents	represent	VERB
gs-3751	148	10	a	a	DET
gs-3751	148	11	bidirectional	bidirectional	ADJ
gs-3751	148	12	communication	communication	NOUN
gs-3751	148	13	network	network	NOUN
gs-3751	148	14	linking	link	VERB
gs-3751	148	15	the	the	DET
gs-3751	148	16	gastrointestinal	gastrointestinal	ADJ
gs-3751	148	17	tract	tract	NOUN
gs-3751	148	18	and	and	CCONJ
gs-3751	148	19	the	the	DET
gs-3751	148	20	central	central	ADJ
gs-3751	148	21	nervous	nervous	ADJ
gs-3751	148	22	system	system	NOUN
gs-3751	148	23	(	(	PUNCT
gs-3751	148	24	cns	cns	NOUN
gs-3751	148	25	)	)	PUNCT
gs-3751	148	26	.	.	PUNCT
gs-3751	149	1	this	this	DET
gs-3751	149	2	axis	axis	ADJ
gs-3751	149	3	integrates	integrate	NOUN
gs-3751	149	4	neural	neural	ADJ
gs-3751	149	5	,	,	PUNCT
gs-3751	149	6	endocrine	endocrine	NOUN
gs-3751	149	7	,	,	PUNCT
gs-3751	149	8	immune	immune	NOUN
gs-3751	149	9	,	,	PUNCT
gs-3751	149	10	and	and	CCONJ
gs-3751	149	11	metabolic	metabolic	NOUN
gs-3751	149	12	pathways	pathway	NOUN
gs-3751	149	13	,	,	PUNCT
gs-3751	149	14	with	with	ADP
gs-3751	149	15	the	the	DET
gs-3751	149	16	gut	gut	NOUN
gs-3751	149	17	microbiome	microbiome	NOUN
gs-3751	149	18	playing	play	VERB
gs-3751	149	19	a	a	DET
gs-3751	149	20	central	central	ADJ
gs-3751	149	21	role	role	NOUN
gs-3751	149	22	in	in	ADP
gs-3751	149	23	modulating	modulate	VERB
gs-3751	149	24	these	these	DET
gs-3751	149	25	interactions	interaction	NOUN
gs-3751	149	26	.	.	PUNCT
gs-3751	150	1	the	the	DET
gs-3751	150	2	vagus	vagus	PROPN
gs-3751	150	3	nerve	nerve	NOUN
gs-3751	150	4	,	,	PUNCT
gs-3751	150	5	a	a	DET
gs-3751	150	6	critical	critical	ADJ
gs-3751	150	7	component	component	NOUN
gs-3751	150	8	of	of	ADP
gs-3751	150	9	the	the	DET
gs-3751	150	10	parasympathetic	parasympathetic	ADJ
gs-3751	150	11	nervous	nervous	ADJ
gs-3751	150	12	system	system	NOUN
gs-3751	150	13	,	,	PUNCT
gs-3751	150	14	serves	serve	VERB
gs-3751	150	15	as	as	ADP
gs-3751	150	16	a	a	DET
gs-3751	150	17	direct	direct	ADJ
gs-3751	150	18	neural	neural	ADJ
gs-3751	150	19	conduit	conduit	NOUN
gs-3751	150	20	,	,	PUNCT
gs-3751	150	21	transmitting	transmit	VERB
gs-3751	150	22	signals	signal	NOUN
gs-3751	150	23	from	from	ADP
gs-3751	150	24	the	the	DET
gs-3751	150	25	gut	gut	NOUN
gs-3751	150	26	to	to	ADP
gs-3751	150	27	the	the	DET
gs-3751	150	28	brain	brain	NOUN
gs-3751	150	29	and	and	CCONJ
gs-3751	150	30	vice	vice	NOUN
gs-3751	150	31	versa	versa	ADV
gs-3751	150	32	.	.	PUNCT
gs-3751	151	1	for	for	ADP
gs-3751	151	2	instance	instance	NOUN
gs-3751	151	3	,	,	PUNCT
gs-3751	151	4	gut	gut	VERB
gs-3751	151	5	georgian	georgian	ADJ
gs-3751	151	6	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3751	151	7	მეცნიერები	მეცნიერები	NOUN
gs-3751	151	8	ტ.	ტ.	VERB
gs-3751	151	9	7	7	NUM
gs-3751	151	10	n	n	DET
gs-3751	151	11	2	2	NUM
gs-3751	151	12	,	,	PUNCT
gs-3751	151	13	2025	2025	NUM
gs-3751	151	14	338	338	NUM
gs-3751	151	15	derived	derive	VERB
gs-3751	151	16	metabolites	metabolite	NOUN
gs-3751	151	17	such	such	ADJ
gs-3751	151	18	as	as	ADP
gs-3751	151	19	short	short	ADJ
gs-3751	151	20	-	-	PUNCT
gs-3751	151	21	chain	chain	NOUN
gs-3751	151	22	fatty	fatty	NOUN
gs-3751	151	23	acids	acid	NOUN
gs-3751	151	24	(	(	PUNCT
gs-3751	151	25	scfas	scfas	NOUN
gs-3751	151	26	)	)	PUNCT
gs-3751	151	27	and	and	CCONJ
gs-3751	151	28	neurotransmitters	neurotransmitter	NOUN
gs-3751	151	29	(	(	PUNCT
gs-3751	151	30	e.g.	e.g.	ADV
gs-3751	151	31	,	,	PUNCT
gs-3751	151	32	serotonin	serotonin	NOUN
gs-3751	151	33	,	,	PUNCT
gs-3751	151	34	dopamine	dopamine	NOUN
gs-3751	151	35	)	)	PUNCT
gs-3751	151	36	influence	influence	NOUN
gs-3751	151	37	brain	brain	NOUN
gs-3751	151	38	function	function	NOUN
gs-3751	151	39	by	by	ADP
gs-3751	151	40	crossing	cross	VERB
gs-3751	151	41	the	the	DET
gs-3751	151	42	blood	blood	NOUN
gs-3751	151	43	-	-	PUNCT
gs-3751	151	44	brain	brain	NOUN
gs-3751	151	45	barrier	barrier	NOUN
gs-3751	151	46	(	(	PUNCT
gs-3751	151	47	bbb	bbb	NOUN
gs-3751	151	48	)	)	PUNCT
gs-3751	151	49	or	or	CCONJ
gs-3751	151	50	activating	activate	VERB
gs-3751	151	51	vagal	vagal	ADJ
gs-3751	151	52	afferents	afferent	NOUN
gs-3751	151	53	.	.	PUNCT
gs-3751	152	1	additionally	additionally	ADV
gs-3751	152	2	,	,	PUNCT
gs-3751	152	3	the	the	DET
gs-3751	152	4	gut	gut	NOUN
gs-3751	152	5	microbiome	microbiome	NOUN
gs-3751	152	6	regulates	regulate	VERB
gs-3751	152	7	systemic	systemic	ADJ
gs-3751	152	8	immunity	immunity	NOUN
gs-3751	152	9	,	,	PUNCT
gs-3751	152	10	with	with	ADP
gs-3751	152	11	dysbiosis	dysbiosis	NOUN
gs-3751	152	12	—	—	PUNCT
gs-3751	152	13	imbalances	imbalance	NOUN
gs-3751	152	14	in	in	ADP
gs-3751	152	15	microbial	microbial	ADJ
gs-3751	152	16	composition	composition	NOUN
gs-3751	152	17	—	—	PUNCT
gs-3751	152	18	linked	link	VERB
gs-3751	152	19	to	to	ADP
gs-3751	152	20	neuroinflammation	neuroinflammation	NOUN
gs-3751	152	21	via	via	ADP
gs-3751	152	22	cytokine	cytokine	ADJ
gs-3751	152	23	release	release	NOUN
gs-3751	152	24	and	and	CCONJ
gs-3751	152	25	microglial	microglial	ADJ
gs-3751	152	26	activation	activation	NOUN
gs-3751	152	27	.	.	PUNCT
gs-3751	153	1	in	in	ADP
gs-3751	153	2	neurodegenerative	neurodegenerative	ADJ
gs-3751	153	3	diseases	disease	NOUN
gs-3751	153	4	like	like	ADP
gs-3751	153	5	alzheimer	alzheimer	PROPN
gs-3751	153	6	’s	’s	PART
gs-3751	153	7	disease	disease	NOUN
gs-3751	153	8	(	(	PUNCT
gs-3751	153	9	ad	ad	NOUN
gs-3751	153	10	)	)	PUNCT
gs-3751	153	11	and	and	CCONJ
gs-3751	153	12	parkinson	parkinson	NOUN
gs-3751	153	13	’s	’s	PART
gs-3751	153	14	disease	disease	NOUN
gs-3751	153	15	(	(	PUNCT
gs-3751	153	16	pd	pd	NOUN
gs-3751	153	17	)	)	PUNCT
gs-3751	153	18	,	,	PUNCT
gs-3751	153	19	disruptions	disruption	NOUN
gs-3751	153	20	in	in	ADP
gs-3751	153	21	the	the	DET
gs-3751	153	22	gba	gba	NOUN
gs-3751	153	23	are	be	AUX
gs-3751	153	24	increasingly	increasingly	ADV
gs-3751	153	25	recognized	recognize	VERB
gs-3751	153	26	as	as	ADP
gs-3751	153	27	early	early	ADJ
gs-3751	153	28	contributors	contributor	NOUN
gs-3751	153	29	to	to	ADP
gs-3751	153	30	pathology	pathology	NOUN
gs-3751	153	31	.	.	PUNCT
gs-3751	154	1	for	for	ADP
gs-3751	154	2	example	example	NOUN
gs-3751	154	3	,	,	PUNCT
gs-3751	154	4	αsynuclein	αsynuclein	NOUN
gs-3751	154	5	aggregates	aggregate	NOUN
gs-3751	154	6	,	,	PUNCT
gs-3751	154	7	a	a	DET
gs-3751	154	8	hallmark	hallmark	NOUN
gs-3751	154	9	of	of	ADP
gs-3751	154	10	pd	pd	PROPN
gs-3751	154	11	,	,	PUNCT
gs-3751	154	12	have	have	AUX
gs-3751	154	13	been	be	AUX
gs-3751	154	14	detected	detect	VERB
gs-3751	154	15	in	in	ADP
gs-3751	154	16	the	the	DET
gs-3751	154	17	enteric	enteric	ADJ
gs-3751	154	18	nervous	nervous	ADJ
gs-3751	154	19	system	system	NOUN
gs-3751	154	20	(	(	PUNCT
gs-3751	154	21	ens	en	NOUN
gs-3751	154	22	)	)	PUNCT
gs-3751	154	23	years	year	NOUN
gs-3751	154	24	before	before	SCONJ
gs-3751	154	25	motor	motor	NOUN
gs-3751	154	26	symptoms	symptom	NOUN
gs-3751	154	27	manifest	manifest	VERB
gs-3751	154	28	,	,	PUNCT
gs-3751	154	29	supporting	support	VERB
gs-3751	154	30	braak	braak	NOUN
gs-3751	154	31	’s	’s	PART
gs-3751	154	32	hypothesis	hypothesis	NOUN
gs-3751	154	33	of	of	ADP
gs-3751	154	34	a	a	DET
gs-3751	154	35	"	"	PUNCT
gs-3751	154	36	gut	gut	NOUN
gs-3751	154	37	-	-	PUNCT
gs-3751	154	38	first	first	ADJ
gs-3751	154	39	"	"	PUNCT
gs-3751	154	40	origin	origin	NOUN
gs-3751	154	41	.	.	PUNCT
gs-3751	155	1	similarly	similarly	ADV
gs-3751	155	2	,	,	PUNCT
gs-3751	155	3	amyloid	amyloid	NOUN
gs-3751	155	4	-	-	PUNCT
gs-3751	155	5	beta	beta	NOUN
gs-3751	155	6	(	(	PUNCT
gs-3751	155	7	aβ	aβ	NOUN
gs-3751	155	8	)	)	PUNCT
gs-3751	155	9	plaques	plaque	NOUN
gs-3751	155	10	in	in	ADP
gs-3751	155	11	ad	ad	NOUN
gs-3751	155	12	are	be	AUX
gs-3751	155	13	associated	associate	VERB
gs-3751	155	14	with	with	ADP
gs-3751	155	15	gut	gut	NOUN
gs-3751	155	16	-	-	PUNCT
gs-3751	155	17	derived	derive	VERB
gs-3751	155	18	inflammatory	inflammatory	ADJ
gs-3751	155	19	mediators	mediator	NOUN
gs-3751	155	20	that	that	PRON
gs-3751	155	21	compromise	compromise	VERB
gs-3751	155	22	bbb	bbb	NOUN
gs-3751	155	23	integrity	integrity	NOUN
gs-3751	155	24	,	,	PUNCT
gs-3751	155	25	allowing	allow	VERB
gs-3751	155	26	neurotoxic	neurotoxic	ADJ
gs-3751	155	27	metabolites	metabolite	NOUN
gs-3751	155	28	like	like	ADP
gs-3751	155	29	trimethylamine	trimethylamine	NOUN
gs-3751	155	30	n	n	CCONJ
gs-3751	155	31	-	-	PUNCT
gs-3751	155	32	oxide	oxide	NOUN
gs-3751	155	33	(	(	PUNCT
gs-3751	155	34	tmao	tmao	PROPN
gs-3751	155	35	)	)	PUNCT
gs-3751	155	36	to	to	PART
gs-3751	155	37	infiltrate	infiltrate	VERB
gs-3751	155	38	the	the	DET
gs-3751	155	39	brain	brain	NOUN
gs-3751	155	40	.	.	PUNCT
gs-3751	156	1	these	these	DET
gs-3751	156	2	findings	finding	NOUN
gs-3751	156	3	underscore	underscore	VERB
gs-3751	156	4	the	the	DET
gs-3751	156	5	microbiome	microbiome	NOUN
gs-3751	156	6	’s	’s	PART
gs-3751	156	7	role	role	NOUN
gs-3751	156	8	in	in	ADP
gs-3751	156	9	both	both	PRON
gs-3751	156	10	initiating	initiate	VERB
gs-3751	156	11	and	and	CCONJ
gs-3751	156	12	propagating	propagate	VERB
gs-3751	156	13	neurodegenerative	neurodegenerative	ADJ
gs-3751	156	14	processes	process	NOUN
gs-3751	156	15	.	.	PUNCT
gs-3751	157	1			VERB
gs-3751	157	2	gut	gut	NOUN
gs-3751	157	3	dysbiosis	dysbiosis	NOUN
gs-3751	157	4	in	in	ADP
gs-3751	157	5	neurodegenerative	neurodegenerative	ADJ
gs-3751	157	6	diseases	disease	NOUN
gs-3751	157	7	alzheimer	alzheimer	PROPN
gs-3751	157	8	’s	’s	PART
gs-3751	157	9	disease	disease	NOUN
gs-3751	157	10	clinical	clinical	ADJ
gs-3751	157	11	and	and	CCONJ
gs-3751	157	12	preclinical	preclinical	ADJ
gs-3751	157	13	studies	study	NOUN
gs-3751	157	14	consistently	consistently	ADV
gs-3751	157	15	report	report	VERB
gs-3751	157	16	altered	alter	VERB
gs-3751	157	17	gut	gut	NOUN
gs-3751	157	18	microbiota	microbiota	NOUN
gs-3751	157	19	profiles	profile	NOUN
gs-3751	157	20	in	in	ADP
gs-3751	157	21	ad	ad	NOUN
gs-3751	157	22	patients	patient	NOUN
gs-3751	157	23	,	,	PUNCT
gs-3751	157	24	characterized	characterize	VERB
gs-3751	157	25	by	by	ADP
gs-3751	157	26	reduced	reduce	VERB
gs-3751	157	27	microbial	microbial	ADJ
gs-3751	157	28	diversity	diversity	NOUN
gs-3751	157	29	and	and	CCONJ
gs-3751	157	30	shifts	shift	NOUN
gs-3751	157	31	in	in	ADP
gs-3751	157	32	specific	specific	ADJ
gs-3751	157	33	taxa	taxa	NOUN
gs-3751	157	34	.	.	PUNCT
gs-3751	158	1	for	for	ADP
gs-3751	158	2	instance	instance	NOUN
gs-3751	158	3	,	,	PUNCT
gs-3751	158	4	bifidobacterium	bifidobacterium	NOUN
gs-3751	158	5	and	and	CCONJ
gs-3751	158	6	lachnospiraceae	lachnospiraceae	NOUN
gs-3751	158	7	are	be	AUX
gs-3751	158	8	often	often	ADV
gs-3751	158	9	depleted	deplete	VERB
gs-3751	158	10	,	,	PUNCT
gs-3751	158	11	while	while	SCONJ
gs-3751	158	12	pro	pro	ADJ
gs-3751	158	13	-	-	ADJ
gs-3751	158	14	inflammatory	inflammatory	ADJ
gs-3751	158	15	genera	genera	NOUN
gs-3751	158	16	like	like	ADP
gs-3751	158	17	escherichia	escherichia	NOUN
gs-3751	158	18	-	-	PUNCT
gs-3751	158	19	shigella	shigella	PROPN
gs-3751	158	20	and	and	CCONJ
gs-3751	158	21	akkermansia	akkermansia	NOUN
gs-3751	158	22	are	be	AUX
gs-3751	158	23	enriched	enrich	VERB
gs-3751	158	24	.	.	PUNCT
gs-3751	159	1	these	these	DET
gs-3751	159	2	changes	change	NOUN
gs-3751	159	3	correlate	correlate	VERB
gs-3751	159	4	with	with	ADP
gs-3751	159	5	elevated	elevated	ADJ
gs-3751	159	6	levels	level	NOUN
gs-3751	159	7	of	of	ADP
gs-3751	159	8	tmao	tmao	PROPN
gs-3751	159	9	,	,	PUNCT
gs-3751	159	10	a	a	DET
gs-3751	159	11	metabolite	metabolite	NOUN
gs-3751	159	12	derived	derive	VERB
gs-3751	159	13	from	from	ADP
gs-3751	159	14	dietary	dietary	ADJ
gs-3751	159	15	choline	choline	NOUN
gs-3751	159	16	and	and	CCONJ
gs-3751	159	17	carnitine	carnitine	NOUN
gs-3751	159	18	,	,	PUNCT
gs-3751	159	19	which	which	PRON
gs-3751	159	20	exacerbates	exacerbate	VERB
gs-3751	159	21	neuroinflammation	neuroinflammation	NOUN
gs-3751	159	22	and	and	CCONJ
gs-3751	159	23	promotes	promote	VERB
gs-3751	159	24	aβ	aβ	PRON
gs-3751	159	25	aggregation	aggregation	NOUN
gs-3751	159	26	.	.	PUNCT
gs-3751	160	1	animal	animal	NOUN
gs-3751	160	2	models	model	NOUN
gs-3751	160	3	further	far	ADV
gs-3751	160	4	demonstrate	demonstrate	VERB
gs-3751	160	5	that	that	SCONJ
gs-3751	160	6	fecal	fecal	ADJ
gs-3751	160	7	microbiota	microbiota	NOUN
gs-3751	160	8	transplantation	transplantation	NOUN
gs-3751	160	9	(	(	PUNCT
gs-3751	160	10	fmt	fmt	NOUN
gs-3751	160	11	)	)	PUNCT
gs-3751	160	12	from	from	ADP
gs-3751	160	13	ad	ad	NOUN
gs-3751	160	14	patients	patient	NOUN
gs-3751	160	15	into	into	ADP
gs-3751	160	16	germ	germ	NOUN
gs-3751	160	17	-	-	PUNCT
gs-3751	160	18	free	free	ADJ
gs-3751	160	19	mice	mice	NOUN
gs-3751	160	20	accelerates	accelerate	VERB
gs-3751	160	21	cognitive	cognitive	ADJ
gs-3751	160	22	decline	decline	NOUN
gs-3751	160	23	and	and	CCONJ
gs-3751	160	24	aβ	aβ	ADP
gs-3751	160	25	deposition	deposition	NOUN
gs-3751	160	26	,	,	PUNCT
gs-3751	160	27	whereas	whereas	SCONJ
gs-3751	160	28	probiotics	probiotic	NOUN
gs-3751	160	29	like	like	ADP
gs-3751	160	30	lactobacillus	lactobacillus	NOUN
gs-3751	160	31	and	and	CCONJ
gs-3751	160	32	bifidobacterium	bifidobacterium	NOUN
gs-3751	160	33	strains	strain	NOUN
gs-3751	160	34	mitigate	mitigate	VERB
gs-3751	160	35	these	these	DET
gs-3751	160	36	effects	effect	NOUN
gs-3751	160	37	by	by	ADP
gs-3751	160	38	restoring	restore	VERB
gs-3751	160	39	scfa	scfa	ADJ
gs-3751	160	40	production	production	NOUN
gs-3751	160	41	.	.	PUNCT
gs-3751	161	1	ad	ad	NOUN
gs-3751	161	2	patients	patient	NOUN
gs-3751	161	3	exhibit	exhibit	VERB
gs-3751	161	4	a	a	DET
gs-3751	161	5	"	"	PUNCT
gs-3751	161	6	pro	pro	ADJ
gs-3751	161	7	-	-	ADJ
gs-3751	161	8	inflammatory	inflammatory	ADJ
gs-3751	161	9	microbiome	microbiome	NOUN
gs-3751	161	10	"	"	PUNCT
gs-3751	161	11	characterized	characterize	VERB
gs-3751	161	12	by	by	ADP
gs-3751	161	13	decreased	decrease	VERB
gs-3751	161	14	bifidobacterium	bifidobacterium	NOUN
gs-3751	161	15	(	(	PUNCT
gs-3751	161	16	a	a	DET
gs-3751	161	17	butyrate	butyrate	ADJ
gs-3751	161	18	producer	producer	NOUN
gs-3751	161	19	)	)	PUNCT
gs-3751	161	20	and	and	CCONJ
gs-3751	161	21	increased	increase	VERB
gs-3751	161	22	proteobacteria	proteobacteria	NOUN
gs-3751	161	23	(	(	PUNCT
gs-3751	161	24	e.g.	e.g.	ADV
gs-3751	161	25	,	,	PUNCT
gs-3751	161	26	escherichia	escherichia	NOUN
gs-3751	161	27	)	)	PUNCT
gs-3751	161	28	.	.	PUNCT
gs-3751	162	1	these	these	DET
gs-3751	162	2	shifts	shift	NOUN
gs-3751	162	3	correlate	correlate	VERB
gs-3751	162	4	with	with	ADP
gs-3751	162	5	elevated	elevated	ADJ
gs-3751	162	6	plasma	plasma	NOUN
gs-3751	162	7	lps	lps	PROPN
gs-3751	162	8	and	and	CCONJ
gs-3751	162	9	interleukin-6	interleukin-6	PROPN
gs-3751	162	10	(	(	PUNCT
gs-3751	162	11	il-6	il-6	NUM
gs-3751	162	12	)	)	PUNCT
gs-3751	162	13	,	,	PUNCT
gs-3751	162	14	which	which	PRON
gs-3751	162	15	promote	promote	VERB
gs-3751	162	16	aβ	aβ	PRON
gs-3751	162	17	deposition	deposition	NOUN
gs-3751	162	18	by	by	ADP
gs-3751	162	19	upregulating	upregulating	ADJ
gs-3751	162	20	β	β	X
gs-3751	162	21	-	-	NOUN
gs-3751	162	22	secretase	secretase	ADJ
gs-3751	162	23	(	(	PUNCT
gs-3751	162	24	bace1	bace1	NOUN
gs-3751	162	25	)	)	PUNCT
gs-3751	162	26	activity	activity	NOUN
gs-3751	162	27	.	.	PUNCT
gs-3751	163	1	notably	notably	ADV
gs-3751	163	2	,	,	PUNCT
gs-3751	163	3	germ	germ	NOUN
gs-3751	163	4	-	-	PUNCT
gs-3751	163	5	free	free	ADJ
gs-3751	163	6	ad	ad	NOUN
gs-3751	163	7	mice	mouse	NOUN
gs-3751	163	8	colonized	colonize	VERB
gs-3751	163	9	with	with	ADP
gs-3751	163	10	ad	ad	NOUN
gs-3751	163	11	patient	patient	ADJ
gs-3751	163	12	microbiota	microbiota	NOUN
gs-3751	163	13	develop	develop	VERB
gs-3751	163	14	hippocampal	hippocampal	ADJ
gs-3751	163	15	atrophy	atrophy	NOUN
gs-3751	163	16	and	and	CCONJ
gs-3751	163	17	spatial	spatial	ADJ
gs-3751	163	18	memory	memory	NOUN
gs-3751	163	19	deficits	deficit	NOUN
gs-3751	163	20	,	,	PUNCT
gs-3751	163	21	reversible	reversible	ADJ
gs-3751	163	22	upon	upon	SCONJ
gs-3751	163	23	fmt	fmt	NOUN
gs-3751	163	24	from	from	ADP
gs-3751	163	25	healthy	healthy	ADJ
gs-3751	163	26	donors	donor	NOUN
gs-3751	163	27	.	.	PUNCT
gs-3751	164	1	mechanistically	mechanistically	ADV
gs-3751	164	2	,	,	PUNCT
gs-3751	164	3	scfas	scfas	NOUN
gs-3751	164	4	such	such	ADJ
gs-3751	164	5	as	as	ADP
gs-3751	164	6	butyrate	butyrate	NOUN
gs-3751	164	7	modulate	modulate	ADJ
gs-3751	164	8	microglial	microglial	ADJ
gs-3751	164	9	activity	activity	NOUN
gs-3751	164	10	,	,	PUNCT
gs-3751	164	11	reducing	reduce	VERB
gs-3751	164	12	neuroinflammatory	neuroinflammatory	ADJ
gs-3751	164	13	responses	response	NOUN
gs-3751	164	14	.	.	PUNCT
gs-3751	165	1	in	in	ADP
gs-3751	165	2	aged	aged	ADJ
gs-3751	165	3	mice	mouse	NOUN
gs-3751	165	4	,	,	PUNCT
gs-3751	165	5	high	high	ADJ
gs-3751	165	6	-	-	PUNCT
gs-3751	165	7	fiber	fiber	NOUN
gs-3751	165	8	diets	diet	NOUN
gs-3751	165	9	elevate	elevate	VERB
gs-3751	165	10	scfa	scfa	ADJ
gs-3751	165	11	levels	level	NOUN
gs-3751	165	12	,	,	PUNCT
gs-3751	165	13	reversing	reverse	VERB
gs-3751	165	14	microglial	microglial	ADJ
gs-3751	165	15	hyperactivation	hyperactivation	NOUN
gs-3751	165	16	and	and	CCONJ
gs-3751	165	17	improving	improve	VERB
gs-3751	165	18	memory	memory	NOUN
gs-3751	165	19	.	.	PUNCT
gs-3751	166	1	conversely	conversely	ADV
gs-3751	166	2	,	,	PUNCT
gs-3751	166	3	tmao	tmao	PROPN
gs-3751	166	4	disrupts	disrupt	VERB
gs-3751	166	5	cholesterol	cholesterol	NOUN
gs-3751	166	6	metabolism	metabolism	NOUN
gs-3751	166	7	,	,	PUNCT
gs-3751	166	8	leading	lead	VERB
gs-3751	166	9	to	to	ADP
gs-3751	166	10	aberrant	aberrant	ADJ
gs-3751	166	11	bile	bile	NOUN
gs-3751	166	12	acid	acid	NOUN
gs-3751	166	13	profiles	profile	NOUN
gs-3751	166	14	that	that	PRON
gs-3751	166	15	impair	impair	VERB
gs-3751	166	16	neuronal	neuronal	ADJ
gs-3751	166	17	function	function	NOUN
gs-3751	166	18	.	.	PUNCT
gs-3751	167	1	these	these	DET
gs-3751	167	2	findings	finding	NOUN
gs-3751	167	3	highlight	highlight	VERB
gs-3751	167	4	the	the	DET
gs-3751	167	5	dual	dual	ADJ
gs-3751	167	6	role	role	NOUN
gs-3751	167	7	of	of	ADP
gs-3751	167	8	gut	gut	NOUN
gs-3751	167	9	metabolites	metabolite	NOUN
gs-3751	167	10	in	in	ADP
gs-3751	167	11	ad	ad	NOUN
gs-3751	167	12	pathogenesis	pathogenesis	NOUN
gs-3751	167	13	—	—	PUNCT
gs-3751	167	14	both	both	CCONJ
gs-3751	167	15	protective	protective	ADJ
gs-3751	167	16	and	and	CCONJ
gs-3751	167	17	detrimental	detrimental	ADJ
gs-3751	167	18	—	—	PUNCT
gs-3751	167	19	depending	depend	VERB
gs-3751	167	20	on	on	ADP
gs-3751	167	21	their	their	PRON
gs-3751	167	22	source	source	NOUN
gs-3751	167	23	and	and	CCONJ
gs-3751	167	24	concentration	concentration	NOUN
gs-3751	167	25	.	.	PUNCT
gs-3751	168	1	scfas	scfas	NOUN
gs-3751	168	2	as	as	ADP
gs-3751	168	3	neuroprotectants	neuroprotectant	NOUN
gs-3751	168	4	:	:	PUNCT
gs-3751	168	5	butyrate	butyrate	ADJ
gs-3751	168	6	supplementation	supplementation	NOUN
gs-3751	168	7	(	(	PUNCT
gs-3751	168	8	1500	1500	NUM
gs-3751	168	9	mg	mg	PROPN
gs-3751	168	10	/	/	SYM
gs-3751	168	11	day	day	NOUN
gs-3751	168	12	)	)	PUNCT
gs-3751	168	13	in	in	ADP
gs-3751	168	14	mild	mild	ADJ
gs-3751	168	15	cognitive	cognitive	ADJ
gs-3751	168	16	impairment	impairment	NOUN
gs-3751	168	17	(	(	PUNCT
gs-3751	168	18	mci	mci	NOUN
gs-3751	168	19	)	)	PUNCT
gs-3751	168	20	patients	patient	NOUN
gs-3751	168	21	improved	improve	VERB
gs-3751	168	22	hippocampal	hippocampal	ADJ
gs-3751	168	23	connectivity	connectivity	NOUN
gs-3751	168	24	on	on	ADP
gs-3751	168	25	fmri	fmri	NOUN
gs-3751	168	26	after	after	ADP
gs-3751	168	27	six	six	NUM
gs-3751	168	28	months	month	NOUN
gs-3751	168	29	.	.	PUNCT
gs-3751	169	1	mechanistically	mechanistically	ADV
gs-3751	169	2	,	,	PUNCT
gs-3751	169	3	butyrate	butyrate	NOUN
gs-3751	169	4	enhances	enhance	VERB
gs-3751	169	5	brain	brain	NOUN
gs-3751	169	6	-	-	PUNCT
gs-3751	169	7	derived	derive	VERB
gs-3751	169	8	neurotrophic	neurotrophic	ADJ
gs-3751	169	9	factor	factor	NOUN
gs-3751	169	10	(	(	PUNCT
gs-3751	169	11	bdnf	bdnf	PROPN
gs-3751	169	12	)	)	PUNCT
gs-3751	169	13	,	,	PUNCT
gs-3751	169	14	critical	critical	ADJ
gs-3751	169	15	for	for	ADP
gs-3751	169	16	synaptic	synaptic	ADJ
gs-3751	169	17	plasticity	plasticity	NOUN
gs-3751	169	18	,	,	PUNCT
gs-3751	169	19	by	by	ADP
gs-3751	169	20	inhibiting	inhibit	VERB
gs-3751	169	21	hdac3	hdac3	NOUN
gs-3751	169	22	.	.	PUNCT
gs-3751	170	1	propionate	propionate	PROPN
gs-3751	170	2	,	,	PUNCT
gs-3751	170	3	however	however	ADV
gs-3751	170	4	,	,	PUNCT
gs-3751	170	5	exhibits	exhibit	VERB
gs-3751	170	6	dual	dual	ADJ
gs-3751	170	7	roles	role	NOUN
gs-3751	170	8	:	:	PUNCT
gs-3751	170	9	at	at	ADP
gs-3751	170	10	low	low	ADJ
gs-3751	170	11	doses	dose	NOUN
gs-3751	170	12	,	,	PUNCT
gs-3751	170	13	it	it	PRON
gs-3751	170	14	reduces	reduce	VERB
gs-3751	170	15	microglial	microglial	ADJ
gs-3751	170	16	activation	activation	NOUN
gs-3751	170	17	,	,	PUNCT
gs-3751	170	18	but	but	CCONJ
gs-3751	170	19	at	at	ADP
gs-3751	170	20	high	high	ADJ
gs-3751	170	21	concentrations	concentration	NOUN
gs-3751	170	22	(	(	PUNCT
gs-3751	170	23	as	as	SCONJ
gs-3751	170	24	seen	see	VERB
gs-3751	170	25	in	in	ADP
gs-3751	170	26	high	high	ADJ
gs-3751	170	27	-	-	PUNCT
gs-3751	170	28	fat	fat	NOUN
gs-3751	170	29	diets	diet	NOUN
gs-3751	170	30	)	)	PUNCT
gs-3751	170	31	,	,	PUNCT
gs-3751	170	32	it	it	PRON
gs-3751	170	33	disrupts	disrupt	VERB
gs-3751	170	34	mitochondrial	mitochondrial	ADJ
gs-3751	170	35	function	function	NOUN
gs-3751	170	36	in	in	ADP
gs-3751	170	37	astrocytes	astrocyte	NOUN
gs-3751	170	38	.	.	PUNCT
gs-3751	171	1	georgian	georgian	ADJ
gs-3751	171	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3751	171	3	მეცნიერები	მეცნიერები	NOUN
gs-3751	171	4	ტ.	ტ.	VERB
gs-3751	171	5	7	7	NUM
gs-3751	171	6	n	n	PRON
gs-3751	171	7	2	2	NUM
gs-3751	171	8	,	,	PUNCT
gs-3751	171	9	2025	2025	NUM
gs-3751	171	10	339	339	NUM
gs-3751	171	11			VERB
gs-3751	171	12	tmao	tmao	PROPN
gs-3751	171	13	and	and	CCONJ
gs-3751	171	14	tau	tau	PROPN
gs-3751	171	15	pathology	pathology	NOUN
gs-3751	171	16	:	:	PUNCT
gs-3751	171	17	beyond	beyond	ADP
gs-3751	171	18	aβ	aβ	NOUN
gs-3751	171	19	,	,	PUNCT
gs-3751	171	20	tmao	tmao	PROPN
gs-3751	171	21	exacerbates	exacerbate	VERB
gs-3751	171	22	tau	tau	PROPN
gs-3751	171	23	hyperphosphorylation	hyperphosphorylation	NOUN
gs-3751	171	24	by	by	ADP
gs-3751	171	25	activating	activate	VERB
gs-3751	171	26	cyclin	cyclin	NOUN
gs-3751	171	27	-	-	PUNCT
gs-3751	171	28	dependent	dependent	ADJ
gs-3751	171	29	kinase	kinase	NOUN
gs-3751	171	30	5	5	NUM
gs-3751	171	31	(	(	PUNCT
gs-3751	171	32	cdk5	cdk5	PROPN
gs-3751	171	33	)	)	PUNCT
gs-3751	171	34	.	.	PUNCT
gs-3751	172	1	in	in	ADP
gs-3751	172	2	ps19	ps19	PROPN
gs-3751	172	3	tauopathy	tauopathy	ADJ
gs-3751	172	4	mice	mouse	NOUN
gs-3751	172	5	,	,	PUNCT
gs-3751	172	6	a	a	DET
gs-3751	172	7	tmao	tmao	PROPN
gs-3751	172	8	-	-	PUNCT
gs-3751	172	9	rich	rich	ADJ
gs-3751	172	10	diet	diet	NOUN
gs-3751	172	11	doubled	double	VERB
gs-3751	172	12	neurofibrillary	neurofibrillary	ADJ
gs-3751	172	13	tangle	tangle	NOUN
gs-3751	172	14	density	density	NOUN
gs-3751	172	15	in	in	ADP
gs-3751	172	16	the	the	DET
gs-3751	172	17	entorhinal	entorhinal	ADJ
gs-3751	172	18	cortex	cortex	NOUN
gs-3751	172	19	.	.	PUNCT
gs-3751	173	1	inhibiting	inhibit	VERB
gs-3751	173	2	tmao	tmao	PROPN
gs-3751	173	3	production	production	NOUN
gs-3751	173	4	with	with	ADP
gs-3751	173	5	resveratrol	resveratrol	NOUN
gs-3751	173	6	(	(	PUNCT
gs-3751	173	7	a	a	DET
gs-3751	173	8	polyphenol	polyphenol	NOUN
gs-3751	173	9	)	)	PUNCT
gs-3751	173	10	reduced	reduce	VERB
gs-3751	173	11	tau	tau	PROPN
gs-3751	173	12	pathology	pathology	NOUN
gs-3751	173	13	by	by	ADP
gs-3751	173	14	40	40	NUM
gs-3751	173	15	%	%	NOUN
gs-3751	173	16	,	,	PUNCT
gs-3751	173	17	highlighting	highlight	VERB
gs-3751	173	18	diet	diet	NOUN
gs-3751	173	19	-	-	PUNCT
gs-3751	173	20	microbe	microbe	NOUN
gs-3751	173	21	interactions	interaction	NOUN
gs-3751	173	22	as	as	ADP
gs-3751	173	23	modifiable	modifiable	ADJ
gs-3751	173	24	risk	risk	NOUN
gs-3751	173	25	factors	factor	NOUN
gs-3751	173	26	.	.	PUNCT
gs-3751	174	1			ADJ
gs-3751	174	2	parkinson	parkinson	NOUN
gs-3751	174	3	’s	’s	PART
gs-3751	174	4	disease	disease	NOUN
gs-3751	174	5	pd	pd	PROPN
gs-3751	174	6	is	be	AUX
gs-3751	174	7	uniquely	uniquely	ADV
gs-3751	174	8	associated	associate	VERB
gs-3751	174	9	with	with	ADP
gs-3751	174	10	gastrointestinal	gastrointestinal	ADJ
gs-3751	174	11	symptoms	symptom	NOUN
gs-3751	174	12	,	,	PUNCT
gs-3751	174	13	including	include	VERB
gs-3751	174	14	constipation	constipation	NOUN
gs-3751	174	15	and	and	CCONJ
gs-3751	174	16	small	small	ADJ
gs-3751	174	17	intestinal	intestinal	ADJ
gs-3751	174	18	bacterial	bacterial	ADJ
gs-3751	174	19	overgrowth	overgrowth	NOUN
gs-3751	174	20	(	(	PUNCT
gs-3751	174	21	sibo	sibo	PROPN
gs-3751	174	22	)	)	PUNCT
gs-3751	174	23	,	,	PUNCT
gs-3751	174	24	which	which	PRON
gs-3751	174	25	often	often	ADV
gs-3751	174	26	precede	precede	VERB
gs-3751	174	27	motor	motor	NOUN
gs-3751	174	28	deficits	deficit	NOUN
gs-3751	174	29	by	by	ADP
gs-3751	174	30	decades	decade	NOUN
gs-3751	174	31	.	.	PUNCT
gs-3751	175	1	dysbiosis	dysbiosis	NOUN
gs-3751	175	2	in	in	ADP
gs-3751	175	3	pd	pd	PROPN
gs-3751	175	4	patients	patient	NOUN
gs-3751	175	5	is	be	AUX
gs-3751	175	6	marked	mark	VERB
gs-3751	175	7	by	by	ADP
gs-3751	175	8	increased	increase	VERB
gs-3751	175	9	enterobacteriaceae	enterobacteriaceae	PROPN
gs-3751	175	10	and	and	CCONJ
gs-3751	175	11	decreased	decrease	VERB
gs-3751	175	12	prevotellaceae	prevotellaceae	NOUN
gs-3751	175	13	,	,	PUNCT
gs-3751	175	14	a	a	DET
gs-3751	175	15	pattern	pattern	NOUN
gs-3751	175	16	linked	link	VERB
gs-3751	175	17	to	to	ADP
gs-3751	175	18	α	α	NOUN
gs-3751	175	19	-	-	PUNCT
gs-3751	175	20	synuclein	synuclein	NOUN
gs-3751	175	21	misfolding	misfolding	NOUN
gs-3751	175	22	and	and	CCONJ
gs-3751	175	23	vagal	vagal	ADJ
gs-3751	175	24	transmission	transmission	NOUN
gs-3751	175	25	.	.	PUNCT
gs-3751	176	1	notably	notably	ADV
gs-3751	176	2	,	,	PUNCT
gs-3751	176	3	curli	curli	NOUN
gs-3751	176	4	,	,	PUNCT
gs-3751	176	5	an	an	DET
gs-3751	176	6	amyloid	amyloid	NOUN
gs-3751	176	7	protein	protein	NOUN
gs-3751	176	8	produced	produce	VERB
gs-3751	176	9	by	by	ADP
gs-3751	176	10	e.	e.	PROPN
gs-3751	176	11	coli	coli	PROPN
gs-3751	176	12	,	,	PUNCT
gs-3751	176	13	cross	cross	ADJ
gs-3751	176	14	-	-	ADJ
gs-3751	176	15	seeds	seeds	ADJ
gs-3751	176	16	α	α	NOUN
gs-3751	176	17	-	-	PUNCT
gs-3751	176	18	synuclein	synuclein	NOUN
gs-3751	176	19	aggregation	aggregation	NOUN
gs-3751	176	20	in	in	ADP
gs-3751	176	21	the	the	DET
gs-3751	176	22	gut	gut	NOUN
gs-3751	176	23	,	,	PUNCT
gs-3751	176	24	which	which	PRON
gs-3751	176	25	then	then	ADV
gs-3751	176	26	propagates	propagate	VERB
gs-3751	176	27	to	to	ADP
gs-3751	176	28	the	the	DET
gs-3751	176	29	brain	brain	NOUN
gs-3751	176	30	via	via	ADP
gs-3751	176	31	the	the	DET
gs-3751	176	32	vagus	vagus	NOUN
gs-3751	176	33	nerve	nerve	NOUN
gs-3751	176	34	.	.	PUNCT
gs-3751	177	1	surgical	surgical	ADJ
gs-3751	177	2	vagotomy	vagotomy	NOUN
gs-3751	177	3	reduces	reduce	VERB
gs-3751	177	4	pd	pd	NOUN
gs-3751	177	5	risk	risk	NOUN
gs-3751	177	6	,	,	PUNCT
gs-3751	177	7	further	far	ADV
gs-3751	177	8	supporting	support	VERB
gs-3751	177	9	this	this	DET
gs-3751	177	10	pathway	pathway	NOUN
gs-3751	177	11	.	.	PUNCT
gs-3751	178	1	animal	animal	NOUN
gs-3751	178	2	studies	study	NOUN
gs-3751	178	3	reveal	reveal	VERB
gs-3751	178	4	that	that	SCONJ
gs-3751	178	5	fmt	fmt	NOUN
gs-3751	178	6	from	from	ADP
gs-3751	178	7	pd	pd	PROPN
gs-3751	178	8	patients	patient	NOUN
gs-3751	178	9	to	to	ADP
gs-3751	178	10	α	α	NOUN
gs-3751	178	11	-	-	PUNCT
gs-3751	178	12	synuclein	synuclein	NOUN
gs-3751	178	13	-	-	PUNCT
gs-3751	178	14	overexpressing	overexpresse	VERB
gs-3751	178	15	mice	mouse	NOUN
gs-3751	178	16	exacerbates	exacerbate	VERB
gs-3751	178	17	motor	motor	NOUN
gs-3751	178	18	symptoms	symptom	NOUN
gs-3751	178	19	,	,	PUNCT
gs-3751	178	20	while	while	SCONJ
gs-3751	178	21	probiotics	probiotic	NOUN
gs-3751	178	22	like	like	ADP
gs-3751	178	23	clostridium	clostridium	NOUN
gs-3751	178	24	butyricum	butyricum	PROPN
gs-3751	178	25	improve	improve	VERB
gs-3751	178	26	gut	gut	NOUN
gs-3751	178	27	barrier	barrier	NOUN
gs-3751	178	28	function	function	NOUN
gs-3751	178	29	and	and	CCONJ
gs-3751	178	30	reduce	reduce	VERB
gs-3751	178	31	neuroinflammation	neuroinflammation	NOUN
gs-3751	178	32	.	.	PUNCT
gs-3751	179	1	additionally	additionally	ADV
gs-3751	179	2	,	,	PUNCT
gs-3751	179	3	gut	gut	NOUN
gs-3751	179	4	-	-	PUNCT
gs-3751	179	5	derived	derive	VERB
gs-3751	179	6	lipopolysaccharides	lipopolysaccharide	NOUN
gs-3751	179	7	(	(	PUNCT
gs-3751	179	8	lps	lps	PROPN
gs-3751	179	9	)	)	PUNCT
gs-3751	179	10	activate	activate	VERB
gs-3751	179	11	tlr	tlr	PROPN
gs-3751	179	12	signaling	signal	VERB
gs-3751	179	13	in	in	ADP
gs-3751	179	14	microglia	microglia	ADJ
gs-3751	179	15	,	,	PUNCT
gs-3751	179	16	amplifying	amplifying	ADJ
gs-3751	179	17	oxidative	oxidative	ADJ
gs-3751	179	18	stress	stress	NOUN
gs-3751	179	19	and	and	CCONJ
gs-3751	179	20	dopaminergic	dopaminergic	ADJ
gs-3751	179	21	neuron	neuron	NOUN
gs-3751	179	22	loss	loss	NOUN
gs-3751	179	23	.	.	PUNCT
gs-3751	180	1	these	these	DET
gs-3751	180	2	insights	insight	NOUN
gs-3751	180	3	position	position	VERB
gs-3751	180	4	the	the	DET
gs-3751	180	5	gut	gut	NOUN
gs-3751	180	6	microbiome	microbiome	NOUN
gs-3751	180	7	as	as	ADP
gs-3751	180	8	both	both	CCONJ
gs-3751	180	9	a	a	DET
gs-3751	180	10	biomarker	biomarker	NOUN
gs-3751	180	11	and	and	CCONJ
gs-3751	180	12	a	a	DET
gs-3751	180	13	therapeutic	therapeutic	ADJ
gs-3751	180	14	target	target	NOUN
gs-3751	180	15	in	in	ADP
gs-3751	180	16	pd	pd	PROPN
gs-3751	180	17	.	.	PROPN
gs-3751	180	18	braak	braak	PROPN
gs-3751	180	19	’s	’s	PART
gs-3751	180	20	staging	stage	VERB
gs-3751	180	21	posits	posit	NOUN
gs-3751	180	22	that	that	PRON
gs-3751	180	23	pd	pd	PROPN
gs-3751	180	24	begins	begin	VERB
gs-3751	180	25	in	in	ADP
gs-3751	180	26	the	the	DET
gs-3751	180	27	gut	gut	NOUN
gs-3751	180	28	,	,	PUNCT
gs-3751	180	29	with	with	ADP
gs-3751	180	30	α	α	NOUN
gs-3751	180	31	-	-	PUNCT
gs-3751	180	32	synuclein	synuclein	NOUN
gs-3751	180	33	pathology	pathology	NOUN
gs-3751	180	34	ascending	ascend	VERB
gs-3751	180	35	via	via	ADP
gs-3751	180	36	the	the	DET
gs-3751	180	37	vagus	vagus	NOUN
gs-3751	180	38	nerve	nerve	NOUN
gs-3751	180	39	.	.	PUNCT
gs-3751	181	1	supporting	support	VERB
gs-3751	181	2	this	this	PRON
gs-3751	181	3	,	,	PUNCT
gs-3751	181	4	α	α	X
gs-3751	181	5	-	-	PUNCT
gs-3751	181	6	synuclein	synuclein	NOUN
gs-3751	181	7	aggregates	aggregate	NOUN
gs-3751	181	8	are	be	AUX
gs-3751	181	9	detectable	detectable	ADJ
gs-3751	181	10	in	in	ADP
gs-3751	181	11	colonic	colonic	ADJ
gs-3751	181	12	biopsies	biopsy	NOUN
gs-3751	181	13	a	a	DET
gs-3751	181	14	decade	decade	NOUN
gs-3751	181	15	before	before	ADP
gs-3751	181	16	motor	motor	NOUN
gs-3751	181	17	onset	onset	NOUN
gs-3751	181	18	.	.	PUNCT
gs-3751	182	1	helicobacter	helicobacter	NOUN
gs-3751	182	2	pylori	pylori	NOUN
gs-3751	182	3	infection	infection	NOUN
gs-3751	182	4	,	,	PUNCT
gs-3751	182	5	prevalent	prevalent	ADJ
gs-3751	182	6	in	in	ADP
gs-3751	182	7	pd	pd	PROPN
gs-3751	182	8	cohorts	cohort	NOUN
gs-3751	182	9	,	,	PUNCT
gs-3751	182	10	exacerbates	exacerbate	VERB
gs-3751	182	11	this	this	DET
gs-3751	182	12	process	process	NOUN
gs-3751	182	13	by	by	ADP
gs-3751	182	14	increasing	increase	VERB
gs-3751	182	15	intestinal	intestinal	ADJ
gs-3751	182	16	permeability	permeability	NOUN
gs-3751	182	17	and	and	CCONJ
gs-3751	182	18	activating	activate	VERB
gs-3751	182	19	peripheral	peripheral	ADJ
gs-3751	182	20	cd4	cd4	PROPN
gs-3751	182	21	+	+	PROPN
gs-3751	182	22	t	t	NOUN
gs-3751	182	23	cells	cell	NOUN
gs-3751	182	24	,	,	PUNCT
gs-3751	182	25	which	which	PRON
gs-3751	182	26	cross	cross	NOUN
gs-3751	182	27	-	-	ADJ
gs-3751	182	28	react	react	ADJ
gs-3751	182	29	with	with	ADP
gs-3751	182	30	neuronal	neuronal	ADJ
gs-3751	182	31	αsynuclein	αsynuclein	NOUN
gs-3751	182	32	epitopes	epitope	NOUN
gs-3751	182	33	.	.	PUNCT
gs-3751	183	1			VERB
gs-3751	183	2	the	the	DET
gs-3751	183	3	role	role	NOUN
gs-3751	183	4	of	of	ADP
gs-3751	183	5	bacterial	bacterial	ADJ
gs-3751	183	6	amyloids	amyloid	NOUN
gs-3751	183	7	:	:	PUNCT
gs-3751	183	8	curli	curli	NOUN
gs-3751	183	9	fibers	fiber	NOUN
gs-3751	183	10	from	from	ADP
gs-3751	183	11	e.	e.	PROPN
gs-3751	183	12	coli	coli	PROPN
gs-3751	183	13	and	and	CCONJ
gs-3751	183	14	salmonella	salmonella	PROPN
gs-3751	183	15	act	act	VERB
gs-3751	183	16	as	as	ADP
gs-3751	183	17	prion	prion	NOUN
gs-3751	183	18	-	-	PUNCT
gs-3751	183	19	like	like	ADJ
gs-3751	183	20	templates	template	NOUN
gs-3751	183	21	,	,	PUNCT
gs-3751	183	22	accelerating	accelerate	VERB
gs-3751	183	23	α	α	NOUN
gs-3751	183	24	-	-	PUNCT
gs-3751	183	25	synuclein	synuclein	NOUN
gs-3751	183	26	misfolding	misfolde	VERB
gs-3751	183	27	in	in	ADP
gs-3751	183	28	the	the	DET
gs-3751	183	29	gut	gut	NOUN
gs-3751	183	30	.	.	PUNCT
gs-3751	184	1	in	in	ADP
gs-3751	184	2	transgenic	transgenic	NOUN
gs-3751	184	3	mice	mouse	NOUN
gs-3751	184	4	,	,	PUNCT
gs-3751	184	5	oral	oral	ADJ
gs-3751	184	6	administration	administration	NOUN
gs-3751	184	7	of	of	ADP
gs-3751	184	8	curli	curli	NOUN
gs-3751	184	9	-	-	PUNCT
gs-3751	184	10	producing	produce	VERB
gs-3751	184	11	e.	e.	PROPN
gs-3751	184	12	coli	coli	NOUN
gs-3751	184	13	increased	increase	VERB
gs-3751	184	14	lewy	lewy	ADJ
gs-3751	184	15	body	body	NOUN
gs-3751	184	16	-	-	PUNCT
gs-3751	184	17	like	like	ADJ
gs-3751	184	18	inclusions	inclusion	NOUN
gs-3751	184	19	in	in	ADP
gs-3751	184	20	the	the	DET
gs-3751	184	21	dorsal	dorsal	NOUN
gs-3751	184	22	motor	motor	NOUN
gs-3751	184	23	nucleus	nucleus	NOUN
gs-3751	184	24	of	of	ADP
gs-3751	184	25	the	the	DET
gs-3751	184	26	vagus	vagus	NOUN
gs-3751	184	27	.	.	PUNCT
gs-3751	185	1	conversely	conversely	ADV
gs-3751	185	2	,	,	PUNCT
gs-3751	185	3	tea	tea	NOUN
gs-3751	185	4	polyphenols	polyphenol	NOUN
gs-3751	185	5	(	(	PUNCT
gs-3751	185	6	e.g.	e.g.	ADV
gs-3751	185	7	,	,	PUNCT
gs-3751	185	8	epigallocatechin	epigallocatechin	PROPN
gs-3751	185	9	gallate	gallate	PROPN
gs-3751	185	10	)	)	PUNCT
gs-3751	185	11	inhibit	inhibit	VERB
gs-3751	185	12	curli	curli	NOUN
gs-3751	185	13	polymerization	polymerization	NOUN
gs-3751	185	14	,	,	PUNCT
gs-3751	185	15	suggesting	suggest	VERB
gs-3751	185	16	dietary	dietary	ADJ
gs-3751	185	17	interventions	intervention	NOUN
gs-3751	185	18	could	could	AUX
gs-3751	185	19	delay	delay	VERB
gs-3751	185	20	pd	pd	NOUN
gs-3751	185	21	progression	progression	NOUN
gs-3751	185	22	.	.	PUNCT
gs-3751	186	1			VERB
gs-3751	186	2	sibo	sibo	NOUN
gs-3751	186	3	and	and	CCONJ
gs-3751	186	4	levodopa	levodopa	NOUN
gs-3751	186	5	resistance	resistance	NOUN
gs-3751	186	6	:	:	PUNCT
gs-3751	186	7	up	up	ADP
gs-3751	186	8	to	to	PART
gs-3751	186	9	60	60	NUM
gs-3751	186	10	%	%	NOUN
gs-3751	186	11	of	of	ADP
gs-3751	186	12	pd	pd	PROPN
gs-3751	186	13	patients	patient	NOUN
gs-3751	186	14	have	have	VERB
gs-3751	186	15	small	small	ADJ
gs-3751	186	16	intestinal	intestinal	ADJ
gs-3751	186	17	bacterial	bacterial	ADJ
gs-3751	186	18	overgrowth	overgrowth	NOUN
gs-3751	186	19	(	(	PUNCT
gs-3751	186	20	sibo	sibo	PROPN
gs-3751	186	21	)	)	PUNCT
gs-3751	186	22	,	,	PUNCT
gs-3751	186	23	which	which	PRON
gs-3751	186	24	interferes	interfere	VERB
gs-3751	186	25	with	with	ADP
gs-3751	186	26	levodopa	levodopa	NOUN
gs-3751	186	27	absorption	absorption	NOUN
gs-3751	186	28	by	by	ADP
gs-3751	186	29	decarboxylating	decarboxylate	VERB
gs-3751	186	30	the	the	DET
gs-3751	186	31	drug	drug	NOUN
gs-3751	186	32	in	in	ADP
gs-3751	186	33	the	the	DET
gs-3751	186	34	gut	gut	PROPN
gs-3751	186	35	.	.	PUNCT
gs-3751	187	1	rifaximin	rifaximin	PROPN
gs-3751	187	2	,	,	PUNCT
gs-3751	187	3	a	a	DET
gs-3751	187	4	non	non	ADJ
gs-3751	187	5	-	-	ADJ
gs-3751	187	6	absorbable	absorbable	ADJ
gs-3751	187	7	antibiotic	antibiotic	NOUN
gs-3751	187	8	,	,	PUNCT
gs-3751	187	9	improved	improve	VERB
gs-3751	187	10	motor	motor	NOUN
gs-3751	187	11	fluctuations	fluctuation	NOUN
gs-3751	187	12	in	in	ADP
gs-3751	187	13	a	a	DET
gs-3751	187	14	phase	phase	NOUN
gs-3751	187	15	ii	ii	NOUN
gs-3751	187	16	trial	trial	NOUN
gs-3751	187	17	by	by	ADP
gs-3751	187	18	reducing	reduce	VERB
gs-3751	187	19	microbial	microbial	ADJ
gs-3751	187	20	levodopa	levodopa	NOUN
gs-3751	187	21	metabolism	metabolism	NOUN
gs-3751	187	22	.	.	PUNCT
gs-3751	188	1	this	this	PRON
gs-3751	188	2	underscores	underscore	VERB
gs-3751	188	3	the	the	DET
gs-3751	188	4	microbiome	microbiome	NOUN
gs-3751	188	5	’s	’s	PART
gs-3751	188	6	role	role	NOUN
gs-3751	188	7	in	in	ADP
gs-3751	188	8	pharmacotherapy	pharmacotherapy	NOUN
gs-3751	188	9	efficacy	efficacy	NOUN
gs-3751	188	10	.	.	PUNCT
gs-3751	189	1			ADJ
gs-3751	189	2	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-3751	189	3	strategies	strategy	NOUN
gs-3751	189	4	targeting	target	VERB
gs-3751	189	5	the	the	DET
gs-3751	189	6	gut	gut	NOUN
gs-3751	189	7	-	-	PUNCT
gs-3751	189	8	brain	brain	NOUN
gs-3751	189	9	axis	axis	NOUN
gs-3751	189	10	probiotics	probiotic	NOUN
gs-3751	189	11	,	,	PUNCT
gs-3751	189	12	prebiotics	prebiotic	NOUN
gs-3751	189	13	,	,	PUNCT
gs-3751	189	14	and	and	CCONJ
gs-3751	189	15	synbiotics	synbiotic	NOUN
gs-3751	189	16	probiotics	probiotic	NOUN
gs-3751	189	17	,	,	PUNCT
gs-3751	189	18	such	such	ADJ
gs-3751	189	19	as	as	ADP
gs-3751	189	20	lactobacillus	lactobacillus	NOUN
gs-3751	189	21	and	and	CCONJ
gs-3751	189	22	bifidobacterium	bifidobacterium	NOUN
gs-3751	189	23	,	,	PUNCT
gs-3751	189	24	have	have	AUX
gs-3751	189	25	shown	show	VERB
gs-3751	189	26	promise	promise	NOUN
gs-3751	189	27	in	in	ADP
gs-3751	189	28	modulating	modulate	VERB
gs-3751	189	29	neuroinflammation	neuroinflammation	NOUN
gs-3751	189	30	and	and	CCONJ
gs-3751	189	31	improving	improve	VERB
gs-3751	189	32	cognitive	cognitive	ADJ
gs-3751	189	33	function	function	NOUN
gs-3751	189	34	in	in	ADP
gs-3751	189	35	ad	ad	NOUN
gs-3751	189	36	models	model	NOUN
gs-3751	189	37	.	.	PUNCT
gs-3751	190	1	in	in	ADP
gs-3751	190	2	pd	pd	PROPN
gs-3751	190	3	,	,	PUNCT
gs-3751	190	4	bacillus	bacillus	NOUN
gs-3751	190	5	subtilis	subtili	NOUN
gs-3751	190	6	inhibits	inhibit	VERB
gs-3751	190	7	α	α	PRON
gs-3751	190	8	-	-	PUNCT
gs-3751	190	9	synuclein	synuclein	NOUN
gs-3751	190	10	aggregation	aggregation	NOUN
gs-3751	190	11	in	in	ADP
gs-3751	190	12	the	the	DET
gs-3751	190	13	gut	gut	NOUN
gs-3751	190	14	,	,	PUNCT
gs-3751	190	15	delaying	delay	VERB
gs-3751	190	16	disease	disease	NOUN
gs-3751	190	17	progression	progression	NOUN
gs-3751	190	18	.	.	PUNCT
gs-3751	191	1	prebiotics	prebiotic	NOUN
gs-3751	191	2	like	like	ADP
gs-3751	191	3	inulin	inulin	NOUN
gs-3751	191	4	and	and	CCONJ
gs-3751	191	5	resistant	resistant	ADJ
gs-3751	191	6	starches	starch	NOUN
gs-3751	191	7	enhance	enhance	VERB
gs-3751	191	8	scfa	scfa	ADJ
gs-3751	191	9	production	production	NOUN
gs-3751	191	10	,	,	PUNCT
gs-3751	191	11	which	which	PRON
gs-3751	191	12	strengthens	strengthen	VERB
gs-3751	191	13	intestinal	intestinal	ADJ
gs-3751	191	14	barrier	barrier	NOUN
gs-3751	191	15	integrity	integrity	NOUN
gs-3751	191	16	and	and	CCONJ
gs-3751	191	17	suppresses	suppress	VERB
gs-3751	191	18	proinflammatory	proinflammatory	ADJ
gs-3751	191	19	cytokines	cytokine	NOUN
gs-3751	191	20	.	.	PUNCT
gs-3751	192	1	synbiotic	synbiotic	ADJ
gs-3751	192	2	formulations	formulation	NOUN
gs-3751	192	3	combining	combine	VERB
gs-3751	192	4	probiotics	probiotic	NOUN
gs-3751	192	5	and	and	CCONJ
gs-3751	192	6	prebiotics	prebiotic	NOUN
gs-3751	192	7	demonstrate	demonstrate	VERB
gs-3751	192	8	georgian	georgian	PROPN
gs-3751	192	9	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3751	192	10	მეცნიერები	მეცნიერები	NOUN
gs-3751	192	11	ტ.	ტ.	VERB
gs-3751	192	12	7	7	NUM
gs-3751	192	13	n	n	PRON
gs-3751	192	14	2	2	NUM
gs-3751	192	15	,	,	PUNCT
gs-3751	192	16	2025	2025	NUM
gs-3751	192	17	340	340	NUM
gs-3751	192	18	synergistic	synergistic	ADJ
gs-3751	192	19	effects	effect	NOUN
gs-3751	192	20	,	,	PUNCT
gs-3751	192	21	as	as	SCONJ
gs-3751	192	22	seen	see	VERB
gs-3751	192	23	in	in	ADP
gs-3751	192	24	a	a	DET
gs-3751	192	25	trial	trial	NOUN
gs-3751	192	26	where	where	SCONJ
gs-3751	192	27	fermented	ferment	VERB
gs-3751	192	28	foods	food	NOUN
gs-3751	192	29	reduced	reduce	VERB
gs-3751	192	30	systemic	systemic	ADJ
gs-3751	192	31	inflammation	inflammation	NOUN
gs-3751	192	32	and	and	CCONJ
gs-3751	192	33	improved	improve	VERB
gs-3751	192	34	gut	gut	NOUN
gs-3751	192	35	diversity	diversity	NOUN
gs-3751	192	36	in	in	ADP
gs-3751	192	37	pd	pd	NOUN
gs-3751	192	38	patients	patient	NOUN
gs-3751	192	39	.	.	PUNCT
gs-3751	193	1	not	not	PART
gs-3751	193	2	all	all	DET
gs-3751	193	3	probiotics	probiotic	NOUN
gs-3751	193	4	are	be	AUX
gs-3751	193	5	equal	equal	ADJ
gs-3751	193	6	.	.	PUNCT
gs-3751	194	1	lactobacillus	lactobacillus	NOUN
gs-3751	194	2	plantarum	plantarum	NOUN
gs-3751	194	3	ps128	ps128	NOUN
gs-3751	194	4	reduced	reduce	VERB
gs-3751	194	5	motor	motor	NOUN
gs-3751	194	6	symptoms	symptom	NOUN
gs-3751	194	7	in	in	ADP
gs-3751	194	8	pd	pd	PROPN
gs-3751	194	9	patients	patient	NOUN
gs-3751	194	10	by	by	ADP
gs-3751	194	11	30	30	NUM
gs-3751	194	12	%	%	NOUN
gs-3751	194	13	in	in	ADP
gs-3751	194	14	a	a	DET
gs-3751	194	15	12	12	NUM
gs-3751	194	16	-	-	PUNCT
gs-3751	194	17	week	week	NOUN
gs-3751	194	18	trial	trial	NOUN
gs-3751	194	19	,	,	PUNCT
gs-3751	194	20	likely	likely	ADJ
gs-3751	194	21	via	via	ADP
gs-3751	194	22	dopamine	dopamine	NOUN
gs-3751	194	23	receptor	receptor	NOUN
gs-3751	194	24	upregulation	upregulation	NOUN
gs-3751	194	25	.	.	PUNCT
gs-3751	195	1	in	in	ADP
gs-3751	195	2	contrast	contrast	NOUN
gs-3751	195	3	,	,	PUNCT
gs-3751	195	4	l.	l.	PROPN
gs-3751	195	5	reuteri	reuteri	PROPN
gs-3751	195	6	worsened	worsen	VERB
gs-3751	195	7	cognition	cognition	NOUN
gs-3751	195	8	in	in	ADP
gs-3751	195	9	ad	ad	NOUN
gs-3751	195	10	mice	mouse	NOUN
gs-3751	195	11	by	by	ADP
gs-3751	195	12	increasing	increase	VERB
gs-3751	195	13	hippocampal	hippocampal	ADJ
gs-3751	195	14	il-1β	il-1β	PROPN
gs-3751	195	15	,	,	PUNCT
gs-3751	195	16	emphasizing	emphasize	VERB
gs-3751	195	17	the	the	DET
gs-3751	195	18	need	need	NOUN
gs-3751	195	19	for	for	ADP
gs-3751	195	20	strain	strain	NOUN
gs-3751	195	21	-	-	PUNCT
gs-3751	195	22	specific	specific	ADJ
gs-3751	195	23	validation	validation	NOUN
gs-3751	195	24	.	.	PUNCT
gs-3751	196	1	fecal	fecal	ADJ
gs-3751	196	2	microbiota	microbiota	NOUN
gs-3751	196	3	transplantation	transplantation	NOUN
gs-3751	196	4	(	(	PUNCT
gs-3751	196	5	fmt	fmt	NOUN
gs-3751	196	6	):	):	PUNCT
gs-3751	196	7	beyond	beyond	ADP
gs-3751	196	8	clostridium	clostridium	NOUN
gs-3751	196	9	difficile	difficile	NOUN
gs-3751	196	10	fmt	fmt	NOUN
gs-3751	196	11	’s	’s	PART
gs-3751	196	12	success	success	NOUN
gs-3751	196	13	in	in	ADP
gs-3751	196	14	pd	pd	PROPN
gs-3751	196	15	extends	extend	VERB
gs-3751	196	16	to	to	ADP
gs-3751	196	17	non	non	ADJ
gs-3751	196	18	-	-	ADJ
gs-3751	196	19	motor	motor	ADJ
gs-3751	196	20	symptoms	symptom	NOUN
gs-3751	196	21	.	.	PUNCT
gs-3751	197	1	a	a	DET
gs-3751	197	2	2024	2024	NUM
gs-3751	197	3	study	study	NOUN
gs-3751	197	4	reported	report	VERB
gs-3751	197	5	50	50	NUM
gs-3751	197	6	%	%	NOUN
gs-3751	197	7	reduction	reduction	NOUN
gs-3751	197	8	in	in	ADP
gs-3751	197	9	constipation	constipation	NOUN
gs-3751	197	10	and	and	CCONJ
gs-3751	197	11	20	20	NUM
gs-3751	197	12	%	%	NOUN
gs-3751	197	13	improvement	improvement	NOUN
gs-3751	197	14	in	in	ADP
gs-3751	197	15	sleep	sleep	NOUN
gs-3751	197	16	quality	quality	NOUN
gs-3751	197	17	post	post	NOUN
gs-3751	197	18	-	-	ADJ
gs-3751	197	19	fmt	fmt	ADJ
gs-3751	197	20	,	,	PUNCT
gs-3751	197	21	linked	link	VERB
gs-3751	197	22	to	to	ADP
gs-3751	197	23	increased	increase	VERB
gs-3751	197	24	prevotella	prevotella	NOUN
gs-3751	197	25	and	and	CCONJ
gs-3751	197	26	butyrate	butyrate	NOUN
gs-3751	197	27	synthesis	synthesis	NOUN
gs-3751	197	28	.	.	PUNCT
gs-3751	198	1	however	however	ADV
gs-3751	198	2	,	,	PUNCT
gs-3751	198	3	long	long	ADJ
gs-3751	198	4	-	-	PUNCT
gs-3751	198	5	term	term	NOUN
gs-3751	198	6	risks	risk	NOUN
gs-3751	198	7	include	include	VERB
gs-3751	198	8	weight	weight	NOUN
gs-3751	198	9	gain	gain	NOUN
gs-3751	198	10	and	and	CCONJ
gs-3751	198	11	transfer	transfer	NOUN
gs-3751	198	12	of	of	ADP
gs-3751	198	13	antibiotic	antibiotic	ADJ
gs-3751	198	14	resistance	resistance	NOUN
gs-3751	198	15	genes	gene	NOUN
gs-3751	198	16	,	,	PUNCT
gs-3751	198	17	necessitating	necessitate	VERB
gs-3751	198	18	rigorous	rigorous	ADJ
gs-3751	198	19	donor	donor	NOUN
gs-3751	198	20	screening	screen	VERB
gs-3751	198	21	.	.	PUNCT
gs-3751	199	1	small	small	ADJ
gs-3751	199	2	molecules	molecule	NOUN
gs-3751	199	3	:	:	PUNCT
gs-3751	199	4	from	from	ADP
gs-3751	199	5	bench	bench	NOUN
gs-3751	199	6	to	to	ADP
gs-3751	199	7	bedside	bedside	NOUN
gs-3751	199	8	tmao	tmao	PROPN
gs-3751	199	9	inhibitors	inhibitor	NOUN
gs-3751	199	10	:	:	PUNCT
gs-3751	199	11	3,3	3,3	NUM
gs-3751	199	12	-	-	PUNCT
gs-3751	199	13	dimethyl-1	dimethyl-1	NUM
gs-3751	199	14	-	-	PUNCT
gs-3751	199	15	butanol	butanol	NOUN
gs-3751	199	16	(	(	PUNCT
gs-3751	199	17	dmb	dmb	PROPN
gs-3751	199	18	)	)	PUNCT
gs-3751	199	19	reduced	reduce	VERB
gs-3751	199	20	tmao	tmao	PROPN
gs-3751	199	21	levels	level	NOUN
gs-3751	199	22	by	by	ADP
gs-3751	199	23	60	60	NUM
gs-3751	199	24	%	%	NOUN
gs-3751	199	25	in	in	ADP
gs-3751	199	26	ad	ad	NOUN
gs-3751	199	27	patients	patient	NOUN
gs-3751	199	28	,	,	PUNCT
gs-3751	199	29	correlating	correlate	VERB
gs-3751	199	30	with	with	ADP
gs-3751	199	31	slower	slow	ADJ
gs-3751	199	32	hippocampal	hippocampal	ADJ
gs-3751	199	33	atrophy	atrophy	NOUN
gs-3751	199	34	.	.	PUNCT
gs-3751	200	1	bile	bile	NOUN
gs-3751	200	2	acid	acid	NOUN
gs-3751	200	3	modulators	modulator	NOUN
gs-3751	200	4	:	:	PUNCT
gs-3751	200	5	obeticholic	obeticholic	PROPN
gs-3751	200	6	acid	acid	PROPN
gs-3751	200	7	,	,	PUNCT
gs-3751	200	8	a	a	DET
gs-3751	200	9	fxr	fxr	NOUN
gs-3751	200	10	agonist	agonist	NOUN
gs-3751	200	11	,	,	PUNCT
gs-3751	200	12	restored	restore	VERB
gs-3751	200	13	microbial	microbial	ADJ
gs-3751	200	14	diversity	diversity	NOUN
gs-3751	200	15	and	and	CCONJ
gs-3751	200	16	reduced	reduce	VERB
gs-3751	200	17	aβ	aβ	PRON
gs-3751	200	18	plaques	plaque	NOUN
gs-3751	200	19	in	in	ADP
gs-3751	200	20	app	app	PROPN
gs-3751	200	21	/	/	SYM
gs-3751	200	22	ps1	ps1	NOUN
gs-3751	200	23	mice	mouse	NOUN
gs-3751	200	24	by	by	ADP
gs-3751	200	25	enhancing	enhance	VERB
gs-3751	200	26	sulfated	sulfate	VERB
gs-3751	200	27	bile	bile	NOUN
gs-3751	200	28	acid	acid	NOUN
gs-3751	200	29	production	production	NOUN
gs-3751	200	30	.	.	PUNCT
gs-3751	201	1	serotonin	serotonin	NOUN
gs-3751	201	2	agonists	agonist	NOUN
gs-3751	201	3	:	:	PUNCT
gs-3751	201	4	prucalopride	prucalopride	NOUN
gs-3751	201	5	,	,	PUNCT
gs-3751	201	6	a	a	DET
gs-3751	201	7	5	5	NUM
gs-3751	201	8	-	-	PUNCT
gs-3751	201	9	ht4r	ht4r	NOUN
gs-3751	201	10	agonist	agonist	NOUN
gs-3751	201	11	,	,	PUNCT
gs-3751	201	12	improved	improve	VERB
gs-3751	201	13	cognitive	cognitive	ADJ
gs-3751	201	14	scores	score	NOUN
gs-3751	201	15	in	in	ADP
gs-3751	201	16	ad	ad	NOUN
gs-3751	201	17	by	by	ADP
gs-3751	201	18	increasing	increase	VERB
gs-3751	201	19	aβ	aβ	ADP
gs-3751	201	20	clearance	clearance	NOUN
gs-3751	201	21	through	through	ADP
gs-3751	201	22	meningeal	meningeal	ADJ
gs-3751	201	23	lymphatic	lymphatic	ADJ
gs-3751	201	24	drainage	drainage	NOUN
gs-3751	201	25	.	.	PUNCT
gs-3751	202	1	dietary	dietary	ADJ
gs-3751	202	2	interventions	intervention	NOUN
gs-3751	202	3	:	:	PUNCT
gs-3751	202	4	precision	precision	NOUN
gs-3751	202	5	nutrition	nutrition	NOUN
gs-3751	202	6	the	the	DET
gs-3751	202	7	mediterranean	mediterranean	PROPN
gs-3751	202	8	diet	diet	PROPN
gs-3751	202	9	,	,	PUNCT
gs-3751	202	10	rich	rich	ADJ
gs-3751	202	11	in	in	ADP
gs-3751	202	12	polyphenols	polyphenol	NOUN
gs-3751	202	13	and	and	CCONJ
gs-3751	202	14	fiber	fiber	NOUN
gs-3751	202	15	,	,	PUNCT
gs-3751	202	16	increased	increase	VERB
gs-3751	202	17	roseburia	roseburia	NOUN
gs-3751	202	18	and	and	CCONJ
gs-3751	202	19	faecalibacterium	faecalibacterium	NOUN
gs-3751	202	20	in	in	ADP
gs-3751	202	21	ad	ad	NOUN
gs-3751	202	22	patients	patient	NOUN
gs-3751	202	23	,	,	PUNCT
gs-3751	202	24	correlating	correlate	VERB
gs-3751	202	25	with	with	ADP
gs-3751	202	26	lower	low	ADJ
gs-3751	202	27	csf	csf	X
gs-3751	202	28	tau	tau	PROPN
gs-3751	202	29	/	/	SYM
gs-3751	202	30	aβ42	aβ42	PROPN
gs-3751	202	31	ratios	ratio	NOUN
gs-3751	202	32	.	.	PUNCT
gs-3751	203	1	in	in	ADP
gs-3751	203	2	pd	pd	PROPN
gs-3751	203	3	,	,	PUNCT
gs-3751	203	4	a	a	DET
gs-3751	203	5	low	low	ADJ
gs-3751	203	6	-	-	PUNCT
gs-3751	203	7	fermentable	fermentable	ADJ
gs-3751	203	8	oligosaccharide	oligosaccharide	NOUN
gs-3751	203	9	(	(	PUNCT
gs-3751	203	10	fodmap	fodmap	NOUN
gs-3751	203	11	)	)	PUNCT
gs-3751	203	12	diet	diet	NOUN
gs-3751	203	13	reduced	reduce	VERB
gs-3751	203	14	bloating	bloat	VERB
gs-3751	203	15	and	and	CCONJ
gs-3751	203	16	improved	improve	VERB
gs-3751	203	17	levodopa	levodopa	NOUN
gs-3751	203	18	absorption	absorption	NOUN
gs-3751	203	19	by	by	ADP
gs-3751	203	20	minimizing	minimize	VERB
gs-3751	203	21	microbial	microbial	ADJ
gs-3751	203	22	gas	gas	NOUN
gs-3751	203	23	production	production	NOUN
gs-3751	203	24	.	.	PUNCT
gs-3751	204	1	fecal	fecal	ADJ
gs-3751	204	2	microbiota	microbiota	NOUN
gs-3751	204	3	transplantation	transplantation	NOUN
gs-3751	204	4	(	(	PUNCT
gs-3751	204	5	fmt	fmt	NOUN
gs-3751	204	6	)	)	PUNCT
gs-3751	204	7	fmt	fmt	NOUN
gs-3751	204	8	has	have	AUX
gs-3751	204	9	emerged	emerge	VERB
gs-3751	204	10	as	as	ADP
gs-3751	204	11	a	a	DET
gs-3751	204	12	radical	radical	ADJ
gs-3751	204	13	yet	yet	CCONJ
gs-3751	204	14	effective	effective	ADJ
gs-3751	204	15	intervention	intervention	NOUN
gs-3751	204	16	.	.	PUNCT
gs-3751	205	1	in	in	ADP
gs-3751	205	2	a	a	DET
gs-3751	205	3	landmark	landmark	NOUN
gs-3751	205	4	pd	pd	NOUN
gs-3751	205	5	trial	trial	NOUN
gs-3751	205	6	,	,	PUNCT
gs-3751	205	7	fmt	fmt	VERB
gs-3751	205	8	from	from	ADP
gs-3751	205	9	healthy	healthy	ADJ
gs-3751	205	10	donors	donor	NOUN
gs-3751	205	11	improved	improve	VERB
gs-3751	205	12	motor	motor	NOUN
gs-3751	205	13	scores	score	NOUN
gs-3751	205	14	by	by	ADP
gs-3751	205	15	6	6	NUM
gs-3751	205	16	points	point	NOUN
gs-3751	205	17	on	on	ADP
gs-3751	205	18	the	the	DET
gs-3751	205	19	updrs	updrs	ADJ
gs-3751	205	20	scale	scale	NOUN
gs-3751	205	21	,	,	PUNCT
gs-3751	205	22	outperforming	outperforming	NOUN
gs-3751	205	23	placebo	placebo	NOUN
gs-3751	205	24	.	.	PUNCT
gs-3751	206	1	similarly	similarly	ADV
gs-3751	206	2	,	,	PUNCT
gs-3751	206	3	ad	ad	NOUN
gs-3751	206	4	mice	mouse	NOUN
gs-3751	206	5	receiving	receive	VERB
gs-3751	206	6	fmt	fmt	NOUN
gs-3751	206	7	from	from	ADP
gs-3751	206	8	young	young	ADJ
gs-3751	206	9	donors	donor	NOUN
gs-3751	206	10	exhibited	exhibit	VERB
gs-3751	206	11	reduced	reduce	VERB
gs-3751	206	12	aβ	aβ	ADP
gs-3751	206	13	plaques	plaque	NOUN
gs-3751	206	14	and	and	CCONJ
gs-3751	206	15	restored	restore	VERB
gs-3751	206	16	synaptic	synaptic	ADJ
gs-3751	206	17	plasticity	plasticity	NOUN
gs-3751	206	18	.	.	PUNCT
gs-3751	207	1	however	however	ADV
gs-3751	207	2	,	,	PUNCT
gs-3751	207	3	challenges	challenge	NOUN
gs-3751	207	4	remain	remain	VERB
gs-3751	207	5	,	,	PUNCT
gs-3751	207	6	including	include	VERB
gs-3751	207	7	donor	donor	NOUN
gs-3751	207	8	variability	variability	NOUN
gs-3751	207	9	and	and	CCONJ
gs-3751	207	10	the	the	DET
gs-3751	207	11	risk	risk	NOUN
gs-3751	207	12	of	of	ADP
gs-3751	207	13	transferring	transfer	VERB
gs-3751	207	14	pathogenic	pathogenic	ADJ
gs-3751	207	15	strains	strain	NOUN
gs-3751	207	16	.	.	PUNCT
gs-3751	208	1	machine	machine	NOUN
gs-3751	208	2	learning	learn	VERB
gs-3751	208	3	approaches	approach	NOUN
gs-3751	208	4	are	be	AUX
gs-3751	208	5	now	now	ADV
gs-3751	208	6	being	be	AUX
gs-3751	208	7	employed	employ	VERB
gs-3751	208	8	to	to	PART
gs-3751	208	9	identify	identify	VERB
gs-3751	208	10	"	"	PUNCT
gs-3751	208	11	super	super	ADJ
gs-3751	208	12	donors	donor	NOUN
gs-3751	208	13	"	"	PUNCT
gs-3751	208	14	and	and	CCONJ
gs-3751	208	15	optimize	optimize	VERB
gs-3751	208	16	microbial	microbial	ADJ
gs-3751	208	17	consortia	consortium	NOUN
gs-3751	208	18	.	.	PUNCT
gs-3751	209	1	small	small	ADJ
gs-3751	209	2	-	-	PUNCT
gs-3751	209	3	molecule	molecule	NOUN
gs-3751	209	4	therapies	therapy	NOUN
gs-3751	209	5	targeting	target	VERB
gs-3751	209	6	gut	gut	NOUN
gs-3751	209	7	-	-	PUNCT
gs-3751	209	8	derived	derive	VERB
gs-3751	209	9	metabolites	metabolite	NOUN
gs-3751	209	10	offers	offer	VERB
gs-3751	209	11	another	another	DET
gs-3751	209	12	avenue	avenue	NOUN
gs-3751	209	13	.	.	PUNCT
gs-3751	210	1	tmao	tmao	PROPN
gs-3751	210	2	inhibitors	inhibitor	NOUN
gs-3751	210	3	,	,	PUNCT
gs-3751	210	4	such	such	ADJ
gs-3751	210	5	as	as	ADP
gs-3751	210	6	3,3	3,3	NUM
gs-3751	210	7	-	-	PUNCT
gs-3751	210	8	dimethyl1	dimethyl1	NOUN
gs-3751	210	9	-	-	PUNCT
gs-3751	210	10	butanol	butanol	NOUN
gs-3751	210	11	(	(	PUNCT
gs-3751	210	12	dmb	dmb	PROPN
gs-3751	210	13	)	)	PUNCT
gs-3751	210	14	,	,	PUNCT
gs-3751	210	15	block	block	VERB
gs-3751	210	16	microbial	microbial	ADJ
gs-3751	210	17	trimethylamine	trimethylamine	NOUN
gs-3751	210	18	lyases	lyase	NOUN
gs-3751	210	19	,	,	PUNCT
gs-3751	210	20	reducing	reduce	VERB
gs-3751	210	21	tmao	tmao	NOUN
gs-3751	210	22	levels	level	NOUN
gs-3751	210	23	and	and	CCONJ
gs-3751	210	24	attenuating	attenuate	VERB
gs-3751	210	25	neuroinflammation	neuroinflammation	NOUN
gs-3751	210	26	in	in	ADP
gs-3751	210	27	ad	ad	NOUN
gs-3751	210	28	models	model	NOUN
gs-3751	210	29	.	.	PUNCT
gs-3751	211	1	bile	bile	NOUN
gs-3751	211	2	acid	acid	NOUN
gs-3751	211	3	sequestrants	sequestrant	NOUN
gs-3751	211	4	,	,	PUNCT
gs-3751	211	5	which	which	PRON
gs-3751	211	6	modulate	modulate	VERB
gs-3751	211	7	secondary	secondary	ADJ
gs-3751	211	8	bile	bile	NOUN
gs-3751	211	9	acid	acid	NOUN
gs-3751	211	10	production	production	NOUN
gs-3751	211	11	,	,	PUNCT
gs-3751	211	12	are	be	AUX
gs-3751	211	13	being	be	AUX
gs-3751	211	14	tested	test	VERB
gs-3751	211	15	for	for	ADP
gs-3751	211	16	their	their	PRON
gs-3751	211	17	ability	ability	NOUN
gs-3751	211	18	to	to	PART
gs-3751	211	19	restore	restore	VERB
gs-3751	211	20	cholesterol	cholesterol	NOUN
gs-3751	211	21	homeostasis	homeostasis	NOUN
gs-3751	211	22	in	in	ADP
gs-3751	211	23	ad	ad	NOUN
gs-3751	211	24	.	.	PUNCT
gs-3751	212	1	additionally	additionally	ADV
gs-3751	212	2	,	,	PUNCT
gs-3751	212	3	serotonin	serotonin	VERB
gs-3751	212	4	reuptake	reuptake	NOUN
gs-3751	212	5	inhibitors	inhibitor	NOUN
gs-3751	212	6	(	(	PUNCT
gs-3751	212	7	ssris	ssris	NOUN
gs-3751	212	8	)	)	PUNCT
gs-3751	212	9	like	like	ADP
gs-3751	212	10	fluoxetine	fluoxetine	NOUN
gs-3751	212	11	,	,	PUNCT
gs-3751	212	12	originally	originally	ADV
gs-3751	212	13	designed	design	VERB
gs-3751	212	14	for	for	ADP
gs-3751	212	15	depression	depression	NOUN
gs-3751	212	16	,	,	PUNCT
gs-3751	212	17	improve	improve	VERB
gs-3751	212	18	cognitive	cognitive	ADJ
gs-3751	212	19	function	function	NOUN
gs-3751	212	20	in	in	ADP
gs-3751	212	21	long	long	ADJ
gs-3751	212	22	covid	covid	NOUN
gs-3751	212	23	models	model	NOUN
gs-3751	212	24	by	by	ADP
gs-3751	212	25	enhancing	enhance	VERB
gs-3751	212	26	vagal	vagal	ADJ
gs-3751	212	27	signaling	signaling	NOUN
gs-3751	212	28	.	.	PUNCT
gs-3751	213	1	the	the	DET
gs-3751	213	2	exploration	exploration	NOUN
gs-3751	213	3	of	of	ADP
gs-3751	213	4	the	the	DET
gs-3751	213	5	gut	gut	NOUN
gs-3751	213	6	-	-	PUNCT
gs-3751	213	7	brain	brain	NOUN
gs-3751	213	8	axis	axis	NOUN
gs-3751	213	9	(	(	PUNCT
gs-3751	213	10	gba	gba	NOUN
gs-3751	213	11	)	)	PUNCT
gs-3751	213	12	has	have	AUX
gs-3751	213	13	unveiled	unveil	VERB
gs-3751	213	14	a	a	DET
gs-3751	213	15	paradigm	paradigm	NOUN
gs-3751	213	16	shift	shift	NOUN
gs-3751	213	17	in	in	ADP
gs-3751	213	18	understanding	understand	VERB
gs-3751	213	19	neurodegenerative	neurodegenerative	ADJ
gs-3751	213	20	diseases	disease	NOUN
gs-3751	213	21	,	,	PUNCT
gs-3751	213	22	positioning	position	VERB
gs-3751	213	23	the	the	DET
gs-3751	213	24	gut	gut	NOUN
gs-3751	213	25	microbiome	microbiome	NOUN
gs-3751	213	26	not	not	PART
gs-3751	213	27	merely	merely	ADV
gs-3751	213	28	as	as	ADP
gs-3751	213	29	a	a	DET
gs-3751	213	30	passive	passive	ADJ
gs-3751	213	31	bystander	bystander	NOUN
gs-3751	213	32	but	but	CCONJ
gs-3751	213	33	as	as	ADP
gs-3751	213	34	an	an	DET
gs-3751	213	35	active	active	ADJ
gs-3751	213	36	modulator	modulator	NOUN
gs-3751	213	37	of	of	ADP
gs-3751	213	38	brain	brain	NOUN
gs-3751	213	39	health	health	NOUN
gs-3751	213	40	.	.	PUNCT
gs-3751	214	1	this	this	DET
gs-3751	214	2	dynamic	dynamic	ADJ
gs-3751	214	3	interplay	interplay	NOUN
gs-3751	214	4	,	,	PUNCT
gs-3751	214	5	mediated	mediate	VERB
gs-3751	214	6	through	through	ADP
gs-3751	214	7	neural	neural	ADJ
gs-3751	214	8	,	,	PUNCT
gs-3751	214	9	endocrine	endocrine	NOUN
gs-3751	214	10	,	,	PUNCT
gs-3751	214	11	and	and	CCONJ
gs-3751	214	12	immune	immune	ADJ
gs-3751	214	13	pathways	pathway	NOUN
gs-3751	214	14	,	,	PUNCT
gs-3751	214	15	challenges	challenge	VERB
gs-3751	214	16	traditional	traditional	ADJ
gs-3751	214	17	neurocentric	neurocentric	ADJ
gs-3751	214	18	models	model	NOUN
gs-3751	214	19	of	of	ADP
gs-3751	214	20	alzheimer	alzheimer	PROPN
gs-3751	214	21	’s	’s	PART
gs-3751	214	22	disease	disease	NOUN
gs-3751	214	23	(	(	PUNCT
gs-3751	214	24	ad	ad	NOUN
gs-3751	214	25	)	)	PUNCT
gs-3751	214	26	and	and	CCONJ
gs-3751	214	27	georgian	georgian	ADJ
gs-3751	214	28	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3751	214	29	მეცნიერები	მეცნიერები	NOUN
gs-3751	214	30	ტ.	ტ.	VERB
gs-3751	214	31	7	7	NUM
gs-3751	214	32	n	n	DET
gs-3751	214	33	2	2	NUM
gs-3751	214	34	,	,	PUNCT
gs-3751	214	35	2025	2025	NUM
gs-3751	214	36	341	341	NUM
gs-3751	214	37	parkinson	parkinson	NOUN
gs-3751	214	38	’s	’s	PART
gs-3751	214	39	disease	disease	NOUN
gs-3751	214	40	(	(	PUNCT
gs-3751	214	41	pd	pd	NOUN
gs-3751	214	42	)	)	PUNCT
gs-3751	214	43	,	,	PUNCT
gs-3751	214	44	urging	urge	VERB
gs-3751	214	45	a	a	DET
gs-3751	214	46	holistic	holistic	ADJ
gs-3751	214	47	approach	approach	NOUN
gs-3751	214	48	that	that	PRON
gs-3751	214	49	integrates	integrate	VERB
gs-3751	214	50	systemic	systemic	ADJ
gs-3751	214	51	and	and	CCONJ
gs-3751	214	52	environmental	environmental	ADJ
gs-3751	214	53	factors	factor	NOUN
gs-3751	214	54	.	.	PUNCT
gs-3751	215	1	while	while	SCONJ
gs-3751	215	2	the	the	DET
gs-3751	215	3	role	role	NOUN
gs-3751	215	4	of	of	ADP
gs-3751	215	5	microbial	microbial	ADJ
gs-3751	215	6	metabolites	metabolite	NOUN
gs-3751	215	7	such	such	ADJ
gs-3751	215	8	as	as	ADP
gs-3751	215	9	short	short	ADJ
gs-3751	215	10	-	-	PUNCT
gs-3751	215	11	chain	chain	NOUN
gs-3751	215	12	fatty	fatty	NOUN
gs-3751	215	13	acids	acid	NOUN
gs-3751	215	14	(	(	PUNCT
gs-3751	215	15	scfas	scfas	NOUN
gs-3751	215	16	)	)	PUNCT
gs-3751	215	17	and	and	CCONJ
gs-3751	215	18	trimethylamine	trimethylamine	NOUN
gs-3751	215	19	noxide	noxide	ADV
gs-3751	215	20	(	(	PUNCT
gs-3751	215	21	tmao	tmao	PROPN
gs-3751	215	22	)	)	PUNCT
gs-3751	215	23	in	in	ADP
gs-3751	215	24	neurodegeneration	neurodegeneration	NOUN
gs-3751	215	25	is	be	AUX
gs-3751	215	26	increasingly	increasingly	ADV
gs-3751	215	27	supported	support	VERB
gs-3751	215	28	by	by	ADP
gs-3751	215	29	preclinical	preclinical	ADJ
gs-3751	215	30	and	and	CCONJ
gs-3751	215	31	clinical	clinical	ADJ
gs-3751	215	32	data	datum	NOUN
gs-3751	215	33	,	,	PUNCT
gs-3751	215	34	the	the	DET
gs-3751	215	35	translation	translation	NOUN
gs-3751	215	36	of	of	ADP
gs-3751	215	37	these	these	DET
gs-3751	215	38	findings	finding	NOUN
gs-3751	215	39	into	into	ADP
gs-3751	215	40	actionable	actionable	ADJ
gs-3751	215	41	therapies	therapy	NOUN
gs-3751	215	42	remains	remain	VERB
gs-3751	215	43	fraught	fraught	ADJ
gs-3751	215	44	with	with	ADP
gs-3751	215	45	complexity	complexity	NOUN
gs-3751	215	46	.	.	PUNCT
gs-3751	216	1	the	the	DET
gs-3751	216	2	heterogeneity	heterogeneity	NOUN
gs-3751	216	3	of	of	ADP
gs-3751	216	4	the	the	DET
gs-3751	216	5	human	human	ADJ
gs-3751	216	6	microbiome	microbiome	NOUN
gs-3751	216	7	,	,	PUNCT
gs-3751	216	8	influenced	influence	VERB
gs-3751	216	9	by	by	ADP
gs-3751	216	10	diet	diet	NOUN
gs-3751	216	11	,	,	PUNCT
gs-3751	216	12	geography	geography	NOUN
gs-3751	216	13	,	,	PUNCT
gs-3751	216	14	and	and	CCONJ
gs-3751	216	15	host	host	NOUN
gs-3751	216	16	genetics	genetic	NOUN
gs-3751	216	17	,	,	PUNCT
gs-3751	216	18	complicates	complicate	VERB
gs-3751	216	19	the	the	DET
gs-3751	216	20	identification	identification	NOUN
gs-3751	216	21	of	of	ADP
gs-3751	216	22	universal	universal	ADJ
gs-3751	216	23	therapeutic	therapeutic	ADJ
gs-3751	216	24	targets	target	NOUN
gs-3751	216	25	.	.	PUNCT
gs-3751	217	1	for	for	ADP
gs-3751	217	2	instance	instance	NOUN
gs-3751	217	3	,	,	PUNCT
gs-3751	217	4	the	the	DET
gs-3751	217	5	depletion	depletion	NOUN
gs-3751	217	6	of	of	ADP
gs-3751	217	7	bifidobacterium	bifidobacterium	NOUN
gs-3751	217	8	in	in	ADP
gs-3751	217	9	ad	ad	NOUN
gs-3751	217	10	patients	patient	NOUN
gs-3751	217	11	,	,	PUNCT
gs-3751	217	12	while	while	SCONJ
gs-3751	217	13	consistent	consistent	ADJ
gs-3751	217	14	across	across	ADP
gs-3751	217	15	western	western	ADJ
gs-3751	217	16	cohorts	cohort	NOUN
gs-3751	217	17	,	,	PUNCT
gs-3751	217	18	is	be	AUX
gs-3751	217	19	less	less	ADV
gs-3751	217	20	pronounced	pronounce	VERB
gs-3751	217	21	in	in	ADP
gs-3751	217	22	asian	asian	ADJ
gs-3751	217	23	populations	population	NOUN
gs-3751	217	24	,	,	PUNCT
gs-3751	217	25	where	where	SCONJ
gs-3751	217	26	dietary	dietary	ADJ
gs-3751	217	27	fiber	fiber	NOUN
gs-3751	217	28	intake	intake	NOUN
gs-3751	217	29	is	be	AUX
gs-3751	217	30	generally	generally	ADV
gs-3751	217	31	higher	high	ADJ
gs-3751	217	32	.	.	PUNCT
gs-3751	218	1	this	this	DET
gs-3751	218	2	geographic	geographic	ADJ
gs-3751	218	3	variability	variability	NOUN
gs-3751	218	4	underscores	underscore	VERB
gs-3751	218	5	the	the	DET
gs-3751	218	6	necessity	necessity	NOUN
gs-3751	218	7	for	for	ADP
gs-3751	218	8	precision	precision	NOUN
gs-3751	218	9	medicine	medicine	NOUN
gs-3751	218	10	approaches	approach	VERB
gs-3751	218	11	that	that	PRON
gs-3751	218	12	tailor	tailor	NOUN
gs-3751	218	13	interventions	intervention	NOUN
gs-3751	218	14	to	to	ADP
gs-3751	218	15	individual	individual	ADJ
gs-3751	218	16	microbiome	microbiome	ADJ
gs-3751	218	17	profiles	profile	NOUN
gs-3751	218	18	rather	rather	ADV
gs-3751	218	19	than	than	ADP
gs-3751	218	20	adopting	adopt	VERB
gs-3751	218	21	a	a	DET
gs-3751	218	22	one	one	NUM
gs-3751	218	23	-	-	PUNCT
gs-3751	218	24	size	size	NOUN
gs-3751	218	25	-	-	PUNCT
gs-3751	218	26	fits	fit	VERB
gs-3751	218	27	-	-	PUNCT
gs-3751	218	28	all	all	PRON
gs-3751	218	29	strategy	strategy	NOUN
gs-3751	218	30	.	.	PUNCT
gs-3751	219	1	a	a	DET
gs-3751	219	2	critical	critical	ADJ
gs-3751	219	3	challenge	challenge	NOUN
gs-3751	219	4	lies	lie	VERB
gs-3751	219	5	in	in	ADP
gs-3751	219	6	disentangling	disentangle	VERB
gs-3751	219	7	causality	causality	NOUN
gs-3751	219	8	from	from	ADP
gs-3751	219	9	correlation	correlation	NOUN
gs-3751	219	10	in	in	ADP
gs-3751	219	11	gut	gut	NOUN
gs-3751	219	12	-	-	PUNCT
gs-3751	219	13	brain	brain	NOUN
gs-3751	219	14	interactions	interaction	NOUN
gs-3751	219	15	.	.	PUNCT
gs-3751	220	1	observational	observational	ADJ
gs-3751	220	2	studies	study	NOUN
gs-3751	220	3	linking	link	VERB
gs-3751	220	4	dysbiosis	dysbiosis	NOUN
gs-3751	220	5	to	to	ADP
gs-3751	220	6	neurodegeneration	neurodegeneration	NOUN
gs-3751	220	7	are	be	AUX
gs-3751	220	8	abundant	abundant	ADJ
gs-3751	220	9	,	,	PUNCT
gs-3751	220	10	yet	yet	CCONJ
gs-3751	220	11	mechanistic	mechanistic	ADJ
gs-3751	220	12	evidence	evidence	NOUN
gs-3751	220	13	remains	remain	VERB
gs-3751	220	14	nascent	nascent	ADJ
gs-3751	220	15	.	.	PUNCT
gs-3751	221	1	for	for	ADP
gs-3751	221	2	example	example	NOUN
gs-3751	221	3	,	,	PUNCT
gs-3751	221	4	while	while	SCONJ
gs-3751	221	5	α	α	NOUN
gs-3751	221	6	-	-	PUNCT
gs-3751	221	7	synuclein	synuclein	NOUN
gs-3751	221	8	aggregates	aggregate	NOUN
gs-3751	221	9	in	in	ADP
gs-3751	221	10	the	the	DET
gs-3751	221	11	enteric	enteric	ADJ
gs-3751	221	12	nervous	nervous	ADJ
gs-3751	221	13	system	system	NOUN
gs-3751	221	14	(	(	PUNCT
gs-3751	221	15	ens	ens	PROPN
gs-3751	221	16	)	)	PUNCT
gs-3751	221	17	of	of	ADP
gs-3751	221	18	pd	pd	PROPN
gs-3751	221	19	patients	patient	NOUN
gs-3751	221	20	predate	predate	VERB
gs-3751	221	21	motor	motor	NOUN
gs-3751	221	22	symptoms	symptom	NOUN
gs-3751	221	23	by	by	ADP
gs-3751	221	24	decades	decade	NOUN
gs-3751	221	25	,	,	PUNCT
gs-3751	221	26	the	the	DET
gs-3751	221	27	precise	precise	ADJ
gs-3751	221	28	triggers	trigger	NOUN
gs-3751	221	29	of	of	ADP
gs-3751	221	30	misfolding	misfolding	NOUN
gs-3751	221	31	—	—	PUNCT
gs-3751	221	32	whether	whether	SCONJ
gs-3751	221	33	microbial	microbial	ADJ
gs-3751	221	34	metabolites	metabolite	NOUN
gs-3751	221	35	,	,	PUNCT
gs-3751	221	36	bacterial	bacterial	ADJ
gs-3751	221	37	amyloids	amyloid	NOUN
gs-3751	221	38	,	,	PUNCT
gs-3751	221	39	or	or	CCONJ
gs-3751	221	40	inflammatory	inflammatory	ADJ
gs-3751	221	41	cytokines	cytokine	NOUN
gs-3751	221	42	—	—	PUNCT
gs-3751	221	43	are	be	AUX
gs-3751	221	44	still	still	ADV
gs-3751	221	45	debated	debate	VERB
gs-3751	221	46	.	.	PUNCT
gs-3751	222	1	the	the	DET
gs-3751	222	2	“	"	PUNCT
gs-3751	222	3	gut	gut	NOUN
gs-3751	222	4	-	-	PUNCT
gs-3751	222	5	first	first	ADJ
gs-3751	222	6	”	"	PUNCT
gs-3751	222	7	hypothesis	hypothesis	NOUN
gs-3751	222	8	posits	posit	NOUN
gs-3751	222	9	that	that	PRON
gs-3751	222	10	pathogens	pathogen	NOUN
gs-3751	222	11	like	like	ADP
gs-3751	222	12	helicobacter	helicobacter	NOUN
gs-3751	222	13	pylori	pylori	NOUN
gs-3751	222	14	or	or	CCONJ
gs-3751	222	15	curli	curli	NOUN
gs-3751	222	16	-	-	PUNCT
gs-3751	222	17	producing	produce	VERB
gs-3751	222	18	escherichia	escherichia	NOUN
gs-3751	222	19	coli	coli	NOUN
gs-3751	222	20	initiate	initiate	VERB
gs-3751	222	21	αsynuclein	αsynuclein	ADJ
gs-3751	222	22	pathology	pathology	PROPN
gs-3751	222	23	,	,	PUNCT
gs-3751	222	24	which	which	PRON
gs-3751	222	25	then	then	ADV
gs-3751	222	26	ascends	ascend	VERB
gs-3751	222	27	to	to	ADP
gs-3751	222	28	the	the	DET
gs-3751	222	29	brain	brain	NOUN
gs-3751	222	30	via	via	ADP
gs-3751	222	31	the	the	DET
gs-3751	222	32	vagus	vagus	NOUN
gs-3751	222	33	nerve	nerve	NOUN
gs-3751	222	34	.	.	PUNCT
gs-3751	223	1	however	however	ADV
gs-3751	223	2	,	,	PUNCT
gs-3751	223	3	this	this	DET
gs-3751	223	4	model	model	NOUN
gs-3751	223	5	does	do	AUX
gs-3751	223	6	not	not	PART
gs-3751	223	7	fully	fully	ADV
gs-3751	223	8	explain	explain	VERB
gs-3751	223	9	cases	case	NOUN
gs-3751	223	10	where	where	SCONJ
gs-3751	223	11	vagotomy	vagotomy	NOUN
gs-3751	223	12	fails	fail	VERB
gs-3751	223	13	to	to	PART
gs-3751	223	14	mitigate	mitigate	VERB
gs-3751	223	15	pd	pd	NOUN
gs-3751	223	16	risk	risk	NOUN
gs-3751	223	17	,	,	PUNCT
gs-3751	223	18	suggesting	suggest	VERB
gs-3751	223	19	alternative	alternative	ADJ
gs-3751	223	20	routes	route	NOUN
gs-3751	223	21	such	such	ADJ
gs-3751	223	22	as	as	ADP
gs-3751	223	23	systemic	systemic	ADJ
gs-3751	223	24	inflammation	inflammation	NOUN
gs-3751	223	25	or	or	CCONJ
gs-3751	223	26	hematogenous	hematogenous	ADJ
gs-3751	223	27	spread	spread	NOUN
gs-3751	223	28	of	of	ADP
gs-3751	223	29	misfolded	misfolde	VERB
gs-3751	223	30	proteins	protein	NOUN
gs-3751	223	31	.	.	PUNCT
gs-3751	224	1	similarly	similarly	ADV
gs-3751	224	2	,	,	PUNCT
gs-3751	224	3	in	in	ADP
gs-3751	224	4	ad	ad	NOUN
gs-3751	224	5	,	,	PUNCT
gs-3751	224	6	the	the	DET
gs-3751	224	7	dual	dual	ADJ
gs-3751	224	8	role	role	NOUN
gs-3751	224	9	of	of	ADP
gs-3751	224	10	scfas	scfas	NOUN
gs-3751	224	11	as	as	SCONJ
gs-3751	224	12	both	both	DET
gs-3751	224	13	neuroprotectants	neuroprotectant	NOUN
gs-3751	224	14	(	(	PUNCT
gs-3751	224	15	via	via	ADP
gs-3751	224	16	hdac	hdac	NOUN
gs-3751	224	17	inhibition	inhibition	NOUN
gs-3751	224	18	)	)	PUNCT
gs-3751	224	19	and	and	CCONJ
gs-3751	224	20	potential	potential	ADJ
gs-3751	224	21	contributors	contributor	NOUN
gs-3751	224	22	to	to	ADP
gs-3751	224	23	neuroinflammation	neuroinflammation	NOUN
gs-3751	224	24	(	(	PUNCT
gs-3751	224	25	at	at	ADP
gs-3751	224	26	high	high	ADJ
gs-3751	224	27	concentrations	concentration	NOUN
gs-3751	224	28	)	)	PUNCT
gs-3751	224	29	highlights	highlight	VERB
gs-3751	224	30	the	the	DET
gs-3751	224	31	context	context	NOUN
gs-3751	224	32	-	-	PUNCT
gs-3751	224	33	dependent	dependent	ADJ
gs-3751	224	34	nature	nature	NOUN
gs-3751	224	35	of	of	ADP
gs-3751	224	36	microbial	microbial	ADJ
gs-3751	224	37	metabolites	metabolite	NOUN
gs-3751	224	38	.	.	PUNCT
gs-3751	225	1	these	these	DET
gs-3751	225	2	ambiguities	ambiguity	NOUN
gs-3751	225	3	demand	demand	VERB
gs-3751	225	4	advanced	advanced	ADJ
gs-3751	225	5	experimental	experimental	ADJ
gs-3751	225	6	models	model	NOUN
gs-3751	225	7	,	,	PUNCT
gs-3751	225	8	such	such	ADJ
gs-3751	225	9	as	as	ADP
gs-3751	225	10	humanized	humanize	VERB
gs-3751	225	11	gnotobiotic	gnotobiotic	ADJ
gs-3751	225	12	mice	mouse	NOUN
gs-3751	225	13	colonized	colonize	VERB
gs-3751	225	14	with	with	ADP
gs-3751	225	15	patient	patient	NOUN
gs-3751	225	16	-	-	PUNCT
gs-3751	225	17	derived	derive	VERB
gs-3751	225	18	microbiota	microbiota	NOUN
gs-3751	225	19	,	,	PUNCT
gs-3751	225	20	to	to	PART
gs-3751	225	21	isolate	isolate	VERB
gs-3751	225	22	microbial	microbial	ADJ
gs-3751	225	23	contributions	contribution	NOUN
gs-3751	225	24	to	to	ADP
gs-3751	225	25	disease	disease	NOUN
gs-3751	225	26	mechanisms	mechanism	NOUN
gs-3751	225	27	.	.	PUNCT
gs-3751	226	1	therapeutic	therapeutic	ADJ
gs-3751	226	2	strategies	strategy	NOUN
gs-3751	226	3	targeting	target	VERB
gs-3751	226	4	the	the	DET
gs-3751	226	5	gba	gba	NOUN
gs-3751	226	6	,	,	PUNCT
gs-3751	226	7	though	though	SCONJ
gs-3751	226	8	promising	promise	VERB
gs-3751	226	9	,	,	PUNCT
gs-3751	226	10	face	face	VERB
gs-3751	226	11	significant	significant	ADJ
gs-3751	226	12	translational	translational	ADJ
gs-3751	226	13	hurdles	hurdle	NOUN
gs-3751	226	14	.	.	PUNCT
gs-3751	227	1	probiotics	probiotic	NOUN
gs-3751	227	2	like	like	ADP
gs-3751	227	3	lactobacillus	lactobacillus	NOUN
gs-3751	227	4	and	and	CCONJ
gs-3751	227	5	bifidobacterium	bifidobacterium	NOUN
gs-3751	227	6	strains	strain	NOUN
gs-3751	227	7	have	have	AUX
gs-3751	227	8	shown	show	VERB
gs-3751	227	9	efficacy	efficacy	NOUN
gs-3751	227	10	in	in	ADP
gs-3751	227	11	animal	animal	NOUN
gs-3751	227	12	models	model	NOUN
gs-3751	227	13	,	,	PUNCT
gs-3751	227	14	yet	yet	CCONJ
gs-3751	227	15	human	human	ADJ
gs-3751	227	16	trials	trial	NOUN
gs-3751	227	17	often	often	ADV
gs-3751	227	18	yield	yield	VERB
gs-3751	227	19	inconsistent	inconsistent	ADJ
gs-3751	227	20	results	result	NOUN
gs-3751	227	21	due	due	ADP
gs-3751	227	22	to	to	ADP
gs-3751	227	23	variations	variation	NOUN
gs-3751	227	24	in	in	ADP
gs-3751	227	25	strain	strain	ADJ
gs-3751	227	26	specificity	specificity	NOUN
gs-3751	227	27	,	,	PUNCT
gs-3751	227	28	dosage	dosage	NOUN
gs-3751	227	29	,	,	PUNCT
gs-3751	227	30	and	and	CCONJ
gs-3751	227	31	baseline	baseline	VERB
gs-3751	227	32	microbiota	microbiota	NOUN
gs-3751	227	33	composition	composition	NOUN
gs-3751	227	34	.	.	PUNCT
gs-3751	228	1	for	for	ADP
gs-3751	228	2	instance	instance	NOUN
gs-3751	228	3	,	,	PUNCT
gs-3751	228	4	lactobacillus	lactobacillus	NOUN
gs-3751	228	5	plantarum	plantarum	NOUN
gs-3751	228	6	ps128	ps128	NOUN
gs-3751	228	7	improved	improve	VERB
gs-3751	228	8	motor	motor	NOUN
gs-3751	228	9	symptoms	symptom	NOUN
gs-3751	228	10	in	in	ADP
gs-3751	228	11	pd	pd	PROPN
gs-3751	228	12	patients	patient	NOUN
gs-3751	228	13	by	by	ADP
gs-3751	228	14	modulating	modulate	VERB
gs-3751	228	15	dopamine	dopamine	NOUN
gs-3751	228	16	receptors	receptor	NOUN
gs-3751	228	17	,	,	PUNCT
gs-3751	228	18	whereas	whereas	SCONJ
gs-3751	228	19	lactobacillus	lactobacillus	NOUN
gs-3751	228	20	reuteri	reuteri	PROPN
gs-3751	228	21	exacerbated	exacerbate	VERB
gs-3751	228	22	neuroinflammation	neuroinflammation	NOUN
gs-3751	228	23	in	in	ADP
gs-3751	228	24	ad	ad	NOUN
gs-3751	228	25	mice	mouse	NOUN
gs-3751	228	26	,	,	PUNCT
gs-3751	228	27	underscoring	underscore	VERB
gs-3751	228	28	the	the	DET
gs-3751	228	29	need	need	NOUN
gs-3751	228	30	for	for	ADP
gs-3751	228	31	rigorous	rigorous	ADJ
gs-3751	228	32	strain	strain	NOUN
gs-3751	228	33	validation	validation	NOUN
gs-3751	228	34	.	.	PUNCT
gs-3751	229	1	fecal	fecal	ADJ
gs-3751	229	2	microbiota	microbiota	NOUN
gs-3751	229	3	transplantation	transplantation	NOUN
gs-3751	229	4	(	(	PUNCT
gs-3751	229	5	fmt	fmt	NOUN
gs-3751	229	6	)	)	PUNCT
gs-3751	229	7	,	,	PUNCT
gs-3751	229	8	while	while	SCONJ
gs-3751	229	9	revolutionary	revolutionary	ADJ
gs-3751	229	10	in	in	ADP
gs-3751	229	11	its	its	PRON
gs-3751	229	12	potential	potential	NOUN
gs-3751	229	13	to	to	PART
gs-3751	229	14	reset	reset	VERB
gs-3751	229	15	dysbiotic	dysbiotic	ADJ
gs-3751	229	16	communities	community	NOUN
gs-3751	229	17	,	,	PUNCT
gs-3751	229	18	introduces	introduce	VERB
gs-3751	229	19	risks	risk	NOUN
gs-3751	229	20	such	such	ADJ
gs-3751	229	21	as	as	ADP
gs-3751	229	22	pathogen	pathogen	NOUN
gs-3751	229	23	transfer	transfer	NOUN
gs-3751	229	24	and	and	CCONJ
gs-3751	229	25	long	long	ADJ
gs-3751	229	26	-	-	PUNCT
gs-3751	229	27	term	term	NOUN
gs-3751	229	28	metabolic	metabolic	NOUN
gs-3751	229	29	consequences	consequence	NOUN
gs-3751	229	30	.	.	PUNCT
gs-3751	230	1	the	the	DET
gs-3751	230	2	case	case	NOUN
gs-3751	230	3	of	of	ADP
gs-3751	230	4	a	a	DET
gs-3751	230	5	pd	pd	NOUN
gs-3751	230	6	patient	patient	NOUN
gs-3751	230	7	developing	develop	VERB
gs-3751	230	8	obesity	obesity	NOUN
gs-3751	230	9	post	post	ADJ
gs-3751	230	10	-	-	ADJ
gs-3751	230	11	fmt	fmt	ADJ
gs-3751	230	12	due	due	ADP
gs-3751	230	13	to	to	ADP
gs-3751	230	14	the	the	DET
gs-3751	230	15	acquisition	acquisition	NOUN
gs-3751	230	16	of	of	ADP
gs-3751	230	17	a	a	DET
gs-3751	230	18	donor	donor	NOUN
gs-3751	230	19	’s	’s	PART
gs-3751	230	20	firmicutes	firmicute	NOUN
gs-3751	230	21	-	-	PUNCT
gs-3751	230	22	dominant	dominant	ADJ
gs-3751	230	23	microbiota	microbiota	NOUN
gs-3751	230	24	illustrates	illustrate	VERB
gs-3751	230	25	the	the	DET
gs-3751	230	26	unintended	unintended	ADJ
gs-3751	230	27	consequences	consequence	NOUN
gs-3751	230	28	of	of	ADP
gs-3751	230	29	altering	alter	VERB
gs-3751	230	30	microbial	microbial	ADJ
gs-3751	230	31	ecosystems	ecosystem	NOUN
gs-3751	230	32	.	.	PUNCT
gs-3751	231	1	furthermore	furthermore	ADV
gs-3751	231	2	,	,	PUNCT
gs-3751	231	3	smallmolecule	smallmolecule	NOUN
gs-3751	231	4	therapies	therapy	NOUN
gs-3751	231	5	targeting	target	VERB
gs-3751	231	6	gut	gut	NOUN
gs-3751	231	7	-	-	PUNCT
gs-3751	231	8	derived	derive	VERB
gs-3751	231	9	metabolites	metabolite	NOUN
gs-3751	231	10	,	,	PUNCT
gs-3751	231	11	such	such	ADJ
gs-3751	231	12	as	as	ADP
gs-3751	231	13	tmao	tmao	NOUN
gs-3751	231	14	inhibitors	inhibitor	NOUN
gs-3751	231	15	,	,	PUNCT
gs-3751	231	16	must	must	AUX
gs-3751	231	17	contend	contend	VERB
gs-3751	231	18	with	with	ADP
gs-3751	231	19	the	the	DET
gs-3751	231	20	pleiotropic	pleiotropic	ADJ
gs-3751	231	21	roles	role	NOUN
gs-3751	231	22	of	of	ADP
gs-3751	231	23	these	these	DET
gs-3751	231	24	compounds	compound	NOUN
gs-3751	231	25	.	.	PUNCT
gs-3751	232	1	tmao	tmao	PROPN
gs-3751	232	2	,	,	PUNCT
gs-3751	232	3	while	while	SCONJ
gs-3751	232	4	pathogenic	pathogenic	ADJ
gs-3751	232	5	in	in	ADP
gs-3751	232	6	ad	ad	NOUN
gs-3751	232	7	,	,	PUNCT
gs-3751	232	8	also	also	ADV
gs-3751	232	9	participates	participate	VERB
gs-3751	232	10	in	in	ADP
gs-3751	232	11	cholesterol	cholesterol	NOUN
gs-3751	232	12	metabolism	metabolism	NOUN
gs-3751	232	13	and	and	CCONJ
gs-3751	232	14	osmotic	osmotic	ADJ
gs-3751	232	15	regulation	regulation	NOUN
gs-3751	232	16	,	,	PUNCT
gs-3751	232	17	raising	raise	VERB
gs-3751	232	18	concerns	concern	NOUN
gs-3751	232	19	about	about	ADP
gs-3751	232	20	systemic	systemic	ADJ
gs-3751	232	21	off	off	ADP
gs-3751	232	22	-	-	PUNCT
gs-3751	232	23	target	target	NOUN
gs-3751	232	24	effects	effect	NOUN
gs-3751	232	25	.	.	PUNCT
gs-3751	233	1	these	these	DET
gs-3751	233	2	challenges	challenge	NOUN
gs-3751	233	3	necessitate	necessitate	ADJ
gs-3751	233	4	a	a	DET
gs-3751	233	5	balanced	balanced	ADJ
gs-3751	233	6	approach	approach	NOUN
gs-3751	233	7	that	that	PRON
gs-3751	233	8	weighs	weigh	VERB
gs-3751	233	9	therapeutic	therapeutic	ADJ
gs-3751	233	10	benefits	benefit	NOUN
gs-3751	233	11	against	against	ADP
gs-3751	233	12	potential	potential	ADJ
gs-3751	233	13	risks	risk	NOUN
gs-3751	233	14	,	,	PUNCT
gs-3751	233	15	guided	guide	VERB
gs-3751	233	16	by	by	ADP
gs-3751	233	17	robust	robust	ADJ
gs-3751	233	18	biomarkers	biomarker	NOUN
gs-3751	233	19	and	and	CCONJ
gs-3751	233	20	real	real	ADJ
gs-3751	233	21	-	-	PUNCT
gs-3751	233	22	time	time	NOUN
gs-3751	233	23	monitoring	monitoring	NOUN
gs-3751	233	24	of	of	ADP
gs-3751	233	25	microbial	microbial	ADJ
gs-3751	233	26	and	and	CCONJ
gs-3751	233	27	metabolic	metabolic	NOUN
gs-3751	233	28	shifts	shift	NOUN
gs-3751	233	29	.	.	PUNCT
gs-3751	234	1	dietary	dietary	ADJ
gs-3751	234	2	interventions	intervention	NOUN
gs-3751	234	3	,	,	PUNCT
gs-3751	234	4	though	though	SCONJ
gs-3751	234	5	non	non	ADJ
gs-3751	234	6	-	-	ADJ
gs-3751	234	7	invasive	invasive	ADJ
gs-3751	234	8	and	and	CCONJ
gs-3751	234	9	scalable	scalable	ADJ
gs-3751	234	10	,	,	PUNCT
gs-3751	234	11	encounter	encounter	ADJ
gs-3751	234	12	practical	practical	ADJ
gs-3751	234	13	limitations	limitation	NOUN
gs-3751	234	14	in	in	ADP
gs-3751	234	15	adherence	adherence	NOUN
gs-3751	234	16	and	and	CCONJ
gs-3751	234	17	individual	individual	ADJ
gs-3751	234	18	responsiveness	responsiveness	NOUN
gs-3751	234	19	.	.	PUNCT
gs-3751	235	1	the	the	DET
gs-3751	235	2	mediterranean	mediterranean	PROPN
gs-3751	235	3	diet	diet	PROPN
gs-3751	235	4	,	,	PUNCT
gs-3751	235	5	rich	rich	ADJ
gs-3751	235	6	in	in	ADP
gs-3751	235	7	polyphenols	polyphenol	NOUN
gs-3751	235	8	and	and	CCONJ
gs-3751	235	9	fiber	fiber	NOUN
gs-3751	235	10	,	,	PUNCT
gs-3751	235	11	georgian	georgian	ADJ
gs-3751	235	12	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3751	235	13	მეცნიერები	მეცნიერები	NOUN
gs-3751	235	14	ტ.	ტ.	VERB
gs-3751	235	15	7	7	NUM
gs-3751	235	16	n	n	PRON
gs-3751	235	17	2	2	NUM
gs-3751	235	18	,	,	PUNCT
gs-3751	235	19	2025	2025	NUM
gs-3751	235	20	342	342	NUM
gs-3751	235	21	consistently	consistently	ADV
gs-3751	235	22	correlates	correlate	VERB
gs-3751	235	23	with	with	ADP
gs-3751	235	24	increased	increase	VERB
gs-3751	235	25	faecalibacterium	faecalibacterium	NOUN
gs-3751	235	26	abundance	abundance	NOUN
gs-3751	235	27	and	and	CCONJ
gs-3751	235	28	reduced	reduce	VERB
gs-3751	235	29	ad	ad	NOUN
gs-3751	235	30	risk	risk	NOUN
gs-3751	235	31	in	in	ADP
gs-3751	235	32	observational	observational	ADJ
gs-3751	235	33	studies	study	NOUN
gs-3751	235	34	.	.	PUNCT
gs-3751	236	1	however	however	ADV
gs-3751	236	2	,	,	PUNCT
gs-3751	236	3	randomized	randomize	VERB
gs-3751	236	4	controlled	control	VERB
gs-3751	236	5	trials	trial	NOUN
gs-3751	236	6	(	(	PUNCT
gs-3751	236	7	rcts	rct	NOUN
gs-3751	236	8	)	)	PUNCT
gs-3751	236	9	often	often	ADV
gs-3751	236	10	fail	fail	VERB
gs-3751	236	11	to	to	PART
gs-3751	236	12	replicate	replicate	VERB
gs-3751	236	13	these	these	DET
gs-3751	236	14	benefits	benefit	NOUN
gs-3751	236	15	,	,	PUNCT
gs-3751	236	16	partly	partly	ADV
gs-3751	236	17	due	due	ADJ
gs-3751	236	18	to	to	ADP
gs-3751	236	19	genetic	genetic	ADJ
gs-3751	236	20	polymorphisms	polymorphism	NOUN
gs-3751	236	21	in	in	ADP
gs-3751	236	22	host	host	NOUN
gs-3751	236	23	nutrient	nutrient	NOUN
gs-3751	236	24	-	-	PUNCT
gs-3751	236	25	sensing	sense	VERB
gs-3751	236	26	pathways	pathway	NOUN
gs-3751	236	27	(	(	PUNCT
gs-3751	236	28	e.g.	e.g.	ADV
gs-3751	236	29	,	,	PUNCT
gs-3751	236	30	tas2r38	tas2r38	VERB
gs-3751	236	31	bitter	bitter	ADJ
gs-3751	236	32	taste	taste	NOUN
gs-3751	236	33	receptors	receptor	NOUN
gs-3751	236	34	)	)	PUNCT
gs-3751	236	35	that	that	PRON
gs-3751	236	36	modulate	modulate	VERB
gs-3751	236	37	dietary	dietary	ADJ
gs-3751	236	38	responses	response	NOUN
gs-3751	236	39	.	.	PUNCT
gs-3751	237	1	similarly	similarly	ADV
gs-3751	237	2	,	,	PUNCT
gs-3751	237	3	ketogenic	ketogenic	ADJ
gs-3751	237	4	diets	diet	NOUN
gs-3751	237	5	,	,	PUNCT
gs-3751	237	6	which	which	PRON
gs-3751	237	7	reduce	reduce	VERB
gs-3751	237	8	amyloid	amyloid	NOUN
gs-3751	237	9	burden	burden	NOUN
gs-3751	237	10	in	in	ADP
gs-3751	237	11	ad	ad	NOUN
gs-3751	237	12	models	model	NOUN
gs-3751	237	13	,	,	PUNCT
gs-3751	237	14	are	be	AUX
gs-3751	237	15	unsustainable	unsustainable	ADJ
gs-3751	237	16	for	for	ADP
gs-3751	237	17	many	many	ADJ
gs-3751	237	18	elderly	elderly	ADJ
gs-3751	237	19	patients	patient	NOUN
gs-3751	237	20	due	due	ADP
gs-3751	237	21	to	to	ADP
gs-3751	237	22	gastrointestinal	gastrointestinal	ADJ
gs-3751	237	23	side	side	NOUN
gs-3751	237	24	effects	effect	NOUN
gs-3751	237	25	.	.	PUNCT
gs-3751	238	1	personalized	personalized	ADJ
gs-3751	238	2	nutrition	nutrition	NOUN
gs-3751	238	3	,	,	PUNCT
gs-3751	238	4	informed	inform	VERB
gs-3751	238	5	by	by	ADP
gs-3751	238	6	microbiome	microbiome	ADJ
gs-3751	238	7	sequencing	sequencing	NOUN
gs-3751	238	8	and	and	CCONJ
gs-3751	238	9	metabolic	metabolic	NOUN
gs-3751	238	10	profiling	profiling	NOUN
gs-3751	238	11	,	,	PUNCT
gs-3751	238	12	could	could	AUX
gs-3751	238	13	bridge	bridge	VERB
gs-3751	238	14	this	this	DET
gs-3751	238	15	gap	gap	NOUN
gs-3751	238	16	.	.	PUNCT
gs-3751	239	1	for	for	ADP
gs-3751	239	2	example	example	NOUN
gs-3751	239	3	,	,	PUNCT
gs-3751	239	4	a	a	DET
gs-3751	239	5	pd	pd	NOUN
gs-3751	239	6	patient	patient	NOUN
gs-3751	239	7	with	with	ADP
gs-3751	239	8	sibo	sibo	PROPN
gs-3751	239	9	might	might	AUX
gs-3751	239	10	benefit	benefit	VERB
gs-3751	239	11	from	from	ADP
gs-3751	239	12	a	a	DET
gs-3751	239	13	low	low	ADJ
gs-3751	239	14	-	-	PUNCT
gs-3751	239	15	fodmap	fodmap	NOUN
gs-3751	239	16	diet	diet	NOUN
gs-3751	239	17	to	to	PART
gs-3751	239	18	minimize	minimize	VERB
gs-3751	239	19	bacterial	bacterial	ADJ
gs-3751	239	20	gas	gas	NOUN
gs-3751	239	21	production	production	NOUN
gs-3751	239	22	,	,	PUNCT
gs-3751	239	23	while	while	SCONJ
gs-3751	239	24	an	an	DET
gs-3751	239	25	ad	ad	NOUN
gs-3751	239	26	patient	patient	NOUN
gs-3751	239	27	with	with	ADP
gs-3751	239	28	low	low	ADJ
gs-3751	239	29	butyrate	butyrate	ADJ
gs-3751	239	30	levels	level	NOUN
gs-3751	239	31	could	could	AUX
gs-3751	239	32	receive	receive	VERB
gs-3751	239	33	tailored	tailor	VERB
gs-3751	239	34	prebiotic	prebiotic	ADJ
gs-3751	239	35	supplementation	supplementation	NOUN
gs-3751	239	36	.	.	PUNCT
gs-3751	240	1	emerging	emerge	VERB
gs-3751	240	2	technologies	technology	NOUN
gs-3751	240	3	,	,	PUNCT
gs-3751	240	4	such	such	ADJ
gs-3751	240	5	as	as	ADP
gs-3751	240	6	continuous	continuous	ADJ
gs-3751	240	7	gut	gut	NOUN
gs-3751	240	8	ph	ph	NOUN
gs-3751	240	9	sensors	sensor	NOUN
gs-3751	240	10	and	and	CCONJ
gs-3751	240	11	ai	ai	AUX
gs-3751	240	12	-	-	PUNCT
gs-3751	240	13	driven	drive	VERB
gs-3751	240	14	dietary	dietary	ADJ
gs-3751	240	15	apps	app	NOUN
gs-3751	240	16	,	,	PUNCT
gs-3751	240	17	hold	hold	VERB
gs-3751	240	18	promise	promise	NOUN
gs-3751	240	19	for	for	ADP
gs-3751	240	20	real	real	ADJ
gs-3751	240	21	-	-	PUNCT
gs-3751	240	22	time	time	NOUN
gs-3751	240	23	adjustment	adjustment	NOUN
gs-3751	240	24	of	of	ADP
gs-3751	240	25	nutritional	nutritional	ADJ
gs-3751	240	26	interventions	intervention	NOUN
gs-3751	240	27	based	base	VERB
gs-3751	240	28	on	on	ADP
gs-3751	240	29	microbial	microbial	ADJ
gs-3751	240	30	feedback	feedback	NOUN
gs-3751	240	31	.	.	PUNCT
gs-3751	241	1	the	the	DET
gs-3751	241	2	integration	integration	NOUN
gs-3751	241	3	of	of	ADP
gs-3751	241	4	artificial	artificial	ADJ
gs-3751	241	5	intelligence	intelligence	NOUN
gs-3751	241	6	(	(	PUNCT
gs-3751	241	7	ai	ai	NOUN
gs-3751	241	8	)	)	PUNCT
gs-3751	241	9	into	into	ADP
gs-3751	241	10	gba	gba	PROPN
gs-3751	241	11	research	research	NOUN
gs-3751	241	12	offers	offer	VERB
gs-3751	241	13	unprecedented	unprecedented	ADJ
gs-3751	241	14	opportunities	opportunity	NOUN
gs-3751	241	15	to	to	PART
gs-3751	241	16	decode	decode	VERB
gs-3751	241	17	microbiome	microbiome	ADJ
gs-3751	241	18	complexity	complexity	NOUN
gs-3751	241	19	and	and	CCONJ
gs-3751	241	20	predict	predict	VERB
gs-3751	241	21	therapeutic	therapeutic	ADJ
gs-3751	241	22	outcomes	outcome	NOUN
gs-3751	241	23	.	.	PUNCT
gs-3751	242	1	machine	machine	NOUN
gs-3751	242	2	learning	learn	VERB
gs-3751	242	3	algorithms	algorithm	NOUN
gs-3751	242	4	trained	train	VERB
gs-3751	242	5	on	on	ADP
gs-3751	242	6	multi	multi	ADJ
gs-3751	242	7	-	-	ADJ
gs-3751	242	8	omics	omics	ADJ
gs-3751	242	9	datasets	dataset	NOUN
gs-3751	242	10	have	have	AUX
gs-3751	242	11	identified	identify	VERB
gs-3751	242	12	microbial	microbial	ADJ
gs-3751	242	13	signatures	signature	NOUN
gs-3751	242	14	predictive	predictive	ADJ
gs-3751	242	15	of	of	ADP
gs-3751	242	16	pd	pd	PROPN
gs-3751	242	17	progression	progression	NOUN
gs-3751	242	18	,	,	PUNCT
gs-3751	242	19	such	such	ADJ
gs-3751	242	20	as	as	ADP
gs-3751	242	21	the	the	DET
gs-3751	242	22	ratio	ratio	NOUN
gs-3751	242	23	of	of	ADP
gs-3751	242	24	enterobacteriaceae	enterobacteriaceae	PROPN
gs-3751	242	25	to	to	PART
gs-3751	242	26	prevotellaceae	prevotellaceae	VERB
gs-3751	242	27	.	.	PUNCT
gs-3751	243	1	ai	ai	VERB
gs-3751	243	2	models	model	NOUN
gs-3751	243	3	like	like	ADP
gs-3751	243	4	the	the	DET
gs-3751	243	5	gut	gut	NOUN
gs-3751	243	6	microbiome	microbiome	NOUN
gs-3751	243	7	aging	age	VERB
gs-3751	243	8	clock	clock	NOUN
gs-3751	243	9	,	,	PUNCT
gs-3751	243	10	which	which	PRON
gs-3751	243	11	estimates	estimate	VERB
gs-3751	243	12	brain	brain	NOUN
gs-3751	243	13	age	age	NOUN
gs-3751	243	14	using	use	VERB
gs-3751	243	15	taxa	taxa	NOUN
gs-3751	243	16	such	such	ADJ
gs-3751	243	17	as	as	ADP
gs-3751	243	18	akkermansia	akkermansia	NOUN
gs-3751	243	19	,	,	PUNCT
gs-3751	243	20	could	could	AUX
gs-3751	243	21	serve	serve	VERB
gs-3751	243	22	as	as	ADP
gs-3751	243	23	early	early	ADJ
gs-3751	243	24	warning	warning	NOUN
gs-3751	243	25	systems	system	NOUN
gs-3751	243	26	for	for	ADP
gs-3751	243	27	neurodegeneration	neurodegeneration	NOUN
gs-3751	243	28	.	.	PUNCT
gs-3751	244	1	however	however	ADV
gs-3751	244	2	,	,	PUNCT
gs-3751	244	3	the	the	DET
gs-3751	244	4	“	"	PUNCT
gs-3751	244	5	black	black	ADJ
gs-3751	244	6	box	box	NOUN
gs-3751	244	7	”	"	PUNCT
gs-3751	244	8	nature	nature	NOUN
gs-3751	244	9	of	of	ADP
gs-3751	244	10	ai	ai	VERB
gs-3751	244	11	poses	pose	NOUN
gs-3751	244	12	challenges	challenge	NOUN
gs-3751	244	13	in	in	ADP
gs-3751	244	14	clinical	clinical	ADJ
gs-3751	244	15	acceptance	acceptance	NOUN
gs-3751	244	16	;	;	PUNCT
gs-3751	244	17	clinicians	clinician	NOUN
gs-3751	244	18	may	may	AUX
gs-3751	244	19	hesitate	hesitate	VERB
gs-3751	244	20	to	to	PART
gs-3751	244	21	adopt	adopt	VERB
gs-3751	244	22	recommendations	recommendation	NOUN
gs-3751	244	23	lacking	lack	VERB
gs-3751	244	24	mechanistic	mechanistic	ADJ
gs-3751	244	25	explanations	explanation	NOUN
gs-3751	244	26	.	.	PUNCT
gs-3751	245	1	hybrid	hybrid	ADJ
gs-3751	245	2	approaches	approach	NOUN
gs-3751	245	3	that	that	PRON
gs-3751	245	4	combine	combine	AUX
gs-3751	245	5	ai	ai	VERB
gs-3751	245	6	with	with	ADP
gs-3751	245	7	mechanistic	mechanistic	ADJ
gs-3751	245	8	studies	study	NOUN
gs-3751	245	9	—	—	PUNCT
gs-3751	245	10	for	for	ADP
gs-3751	245	11	example	example	NOUN
gs-3751	245	12	,	,	PUNCT
gs-3751	245	13	using	use	VERB
gs-3751	245	14	neural	neural	ADJ
gs-3751	245	15	networks	network	NOUN
gs-3751	245	16	to	to	PART
gs-3751	245	17	identify	identify	VERB
gs-3751	245	18	candidate	candidate	NOUN
gs-3751	245	19	microbes	microbe	NOUN
gs-3751	245	20	,	,	PUNCT
gs-3751	245	21	followed	follow	VERB
gs-3751	245	22	by	by	ADP
gs-3751	245	23	gnotobiotic	gnotobiotic	ADJ
gs-3751	245	24	experiments	experiment	NOUN
gs-3751	245	25	to	to	PART
gs-3751	245	26	validate	validate	VERB
gs-3751	245	27	their	their	PRON
gs-3751	245	28	roles	role	NOUN
gs-3751	245	29	—	—	PUNCT
gs-3751	245	30	could	could	AUX
gs-3751	245	31	enhance	enhance	VERB
gs-3751	245	32	transparency	transparency	NOUN
gs-3751	245	33	and	and	CCONJ
gs-3751	245	34	utility	utility	NOUN
gs-3751	245	35	.	.	PUNCT
gs-3751	246	1	additionally	additionally	ADV
gs-3751	246	2	,	,	PUNCT
gs-3751	246	3	ai	ai	ADJ
gs-3751	246	4	-	-	PUNCT
gs-3751	246	5	driven	drive	VERB
gs-3751	246	6	drug	drug	NOUN
gs-3751	246	7	discovery	discovery	NOUN
gs-3751	246	8	platforms	platform	NOUN
gs-3751	246	9	are	be	AUX
gs-3751	246	10	screening	screen	VERB
gs-3751	246	11	microbial	microbial	ADJ
gs-3751	246	12	genomes	genome	NOUN
gs-3751	246	13	for	for	ADP
gs-3751	246	14	novel	novel	ADJ
gs-3751	246	15	neuroprotective	neuroprotective	ADJ
gs-3751	246	16	compounds	compound	NOUN
gs-3751	246	17	,	,	PUNCT
gs-3751	246	18	such	such	ADJ
gs-3751	246	19	as	as	ADP
gs-3751	246	20	bacteriocins	bacteriocin	NOUN
gs-3751	246	21	with	with	ADP
gs-3751	246	22	antiamyloid	antiamyloid	NOUN
gs-3751	246	23	properties	property	NOUN
gs-3751	246	24	,	,	PUNCT
gs-3751	246	25	accelerating	accelerate	VERB
gs-3751	246	26	the	the	DET
gs-3751	246	27	transition	transition	NOUN
gs-3751	246	28	from	from	ADP
gs-3751	246	29	bench	bench	NOUN
gs-3751	246	30	to	to	ADP
gs-3751	246	31	bedside	bedside	NOUN
gs-3751	246	32	.	.	PUNCT
gs-3751	247	1	study	study	NOUN
gs-3751	247	2	selection	selection	NOUN
gs-3751	247	3	the	the	DET
gs-3751	247	4	search	search	NOUN
gs-3751	247	5	which	which	PRON
gs-3751	247	6	was	be	AUX
gs-3751	247	7	from	from	ADP
gs-3751	247	8	multiple	multiple	ADJ
gs-3751	247	9	databases	database	NOUN
gs-3751	247	10	,	,	PUNCT
gs-3751	247	11	including	include	VERB
gs-3751	247	12	pubmed	pubmed	PROPN
gs-3751	247	13	(	(	PUNCT
gs-3751	247	14	1,050	1,050	NUM
gs-3751	247	15	)	)	PUNCT
gs-3751	247	16	,	,	PUNCT
gs-3751	247	17	embase	embase	NOUN
gs-3751	247	18	(	(	PUNCT
gs-3751	247	19	940	940	NUM
gs-3751	247	20	)	)	PUNCT
gs-3751	247	21	,	,	PUNCT
gs-3751	247	22	scopus	scopus	PROPN
gs-3751	247	23	(	(	PUNCT
gs-3751	247	24	1,200	1,200	NUM
gs-3751	247	25	)	)	PUNCT
gs-3751	247	26	,	,	PUNCT
gs-3751	247	27	cochrane	cochrane	NOUN
gs-3751	247	28	library	library	NOUN
gs-3751	247	29	(	(	PUNCT
gs-3751	247	30	678	678	NUM
gs-3751	247	31	)	)	PUNCT
gs-3751	247	32	,	,	PUNCT
gs-3751	247	33	and	and	CCONJ
gs-3751	247	34	google	google	PROPN
gs-3751	247	35	scholar	scholar	NOUN
gs-3751	247	36	(	(	PUNCT
gs-3751	247	37	419	419	NUM
gs-3751	247	38	)	)	PUNCT
gs-3751	247	39	,	,	PUNCT
gs-3751	247	40	a	a	DET
gs-3751	247	41	total	total	NOUN
gs-3751	247	42	of	of	ADP
gs-3751	247	43	4,287	4,287	NUM
gs-3751	247	44	records	record	NOUN
gs-3751	247	45	were	be	AUX
gs-3751	247	46	identified	identify	VERB
gs-3751	247	47	.	.	PUNCT
gs-3751	248	1	based	base	VERB
gs-3751	248	2	on	on	ADP
gs-3751	248	3	the	the	DET
gs-3751	248	4	title	title	NOUN
gs-3751	248	5	and	and	CCONJ
gs-3751	248	6	abstract	abstract	ADJ
gs-3751	248	7	screening	screening	NOUN
gs-3751	248	8	,	,	PUNCT
gs-3751	248	9	3,160	3,160	NUM
gs-3751	248	10	records	record	NOUN
gs-3751	248	11	were	be	AUX
gs-3751	248	12	deemed	deem	VERB
gs-3751	248	13	eligible	eligible	ADJ
gs-3751	248	14	,	,	PUNCT
gs-3751	248	15	after	after	ADP
gs-3751	248	16	excluding	exclude	VERB
gs-3751	248	17	duplicates	duplicate	NOUN
gs-3751	248	18	(	(	PUNCT
gs-3751	248	19	n	n	NOUN
gs-3751	248	20	=	=	NUM
gs-3751	248	21	1,127	1,127	NUM
gs-3751	248	22	)	)	PUNCT
gs-3751	248	23	.	.	PUNCT
gs-3751	249	1	following	follow	VERB
gs-3751	249	2	this	this	DET
gs-3751	249	3	step	step	NOUN
gs-3751	249	4	,	,	PUNCT
gs-3751	249	5	it	it	PRON
gs-3751	249	6	led	lead	VERB
gs-3751	249	7	to	to	ADP
gs-3751	249	8	2,765	2,765	NUM
gs-3751	249	9	studies	study	NOUN
gs-3751	249	10	qualifying	qualify	VERB
gs-3751	249	11	for	for	ADP
gs-3751	249	12	exclusion	exclusion	NOUN
gs-3751	249	13	due	due	ADP
gs-3751	249	14	to	to	ADP
gs-3751	249	15	irrelevance	irrelevance	NOUN
gs-3751	249	16	to	to	ADP
gs-3751	249	17	the	the	DET
gs-3751	249	18	inclusion	inclusion	NOUN
gs-3751	249	19	criteria	criterion	NOUN
gs-3751	249	20	.	.	PUNCT
gs-3751	250	1	eligibility	eligibility	NOUN
gs-3751	250	2	of	of	ADP
gs-3751	250	3	the	the	DET
gs-3751	250	4	studies	study	NOUN
gs-3751	250	5	was	be	AUX
gs-3751	250	6	assessed	assess	VERB
gs-3751	250	7	through	through	ADP
gs-3751	250	8	full	full	ADJ
gs-3751	250	9	-	-	PUNCT
gs-3751	250	10	text	text	NOUN
gs-3751	250	11	review	review	NOUN
gs-3751	250	12	in	in	ADP
gs-3751	250	13	395	395	NUM
gs-3751	250	14	studies	study	NOUN
gs-3751	250	15	.	.	PUNCT
gs-3751	251	1	47	47	NUM
gs-3751	251	2	studies	study	NOUN
gs-3751	251	3	satisfied	satisfy	VERB
gs-3751	251	4	all	all	DET
gs-3751	251	5	the	the	DET
gs-3751	251	6	inclusion	inclusion	NOUN
gs-3751	251	7	criteria	criterion	NOUN
gs-3751	251	8	.	.	PUNCT
gs-3751	252	1	the	the	DET
gs-3751	252	2	prisma	prisma	PROPN
gs-3751	252	3	flowchart	flowchart	PROPN
gs-3751	252	4	for	for	ADP
gs-3751	252	5	study	study	NOUN
gs-3751	252	6	selection	selection	NOUN
gs-3751	252	7	is	be	AUX
gs-3751	252	8	found	find	VERB
gs-3751	252	9	in	in	ADP
gs-3751	252	10	figure	figure	NOUN
gs-3751	252	11	1	1	NUM
gs-3751	252	12	.	.	PUNCT
gs-3751	253	1	georgian	georgian	ADJ
gs-3751	253	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3751	253	3	მეცნიერები	მეცნიერები	NOUN
gs-3751	253	4	ტ.	ტ.	VERB
gs-3751	253	5	7	7	NUM
gs-3751	253	6	n	n	PRON
gs-3751	253	7	2	2	NUM
gs-3751	253	8	,	,	PUNCT
gs-3751	253	9	2025	2025	NUM
gs-3751	253	10	343	343	NUM
gs-3751	253	11	figure-1	figure-1	PROPN
gs-3751	253	12	.	.	PUNCT
gs-3751	254	1	study	study	NOUN
gs-3751	254	2	characteristics	characteristic	NOUN
gs-3751	254	3	:	:	PUNCT
gs-3751	254	4	table	table	NOUN
gs-3751	254	5	1	1	NUM
gs-3751	254	6	summarizes	summarize	VERB
gs-3751	254	7	the	the	DET
gs-3751	254	8	key	key	ADJ
gs-3751	254	9	characteristics	characteristic	NOUN
gs-3751	254	10	of	of	ADP
gs-3751	254	11	the	the	DET
gs-3751	254	12	included	include	VERB
gs-3751	254	13	studies	study	NOUN
gs-3751	254	14	.	.	PUNCT
gs-3751	255	1	most	most	ADJ
gs-3751	255	2	studies	study	NOUN
gs-3751	255	3	were	be	AUX
gs-3751	255	4	randomized	randomize	VERB
gs-3751	255	5	controlled	control	VERB
gs-3751	255	6	trials	trial	NOUN
gs-3751	255	7	(	(	PUNCT
gs-3751	255	8	rcts	rct	NOUN
gs-3751	255	9	)	)	PUNCT
gs-3751	255	10	(	(	PUNCT
gs-3751	255	11	n	n	NOUN
gs-3751	255	12	=	=	SYM
gs-3751	255	13	32	32	NUM
gs-3751	255	14	)	)	PUNCT
gs-3751	255	15	,	,	PUNCT
gs-3751	255	16	whilst	whilst	SCONJ
gs-3751	255	17	the	the	DET
gs-3751	255	18	rest	rest	NOUN
gs-3751	255	19	included	include	VERB
gs-3751	255	20	cohort	cohort	NOUN
gs-3751	255	21	(	(	PUNCT
gs-3751	255	22	n	n	NOUN
gs-3751	255	23	=	=	SYM
gs-3751	255	24	9	9	NUM
gs-3751	255	25	)	)	PUNCT
gs-3751	255	26	and	and	CCONJ
gs-3751	255	27	case	case	NOUN
gs-3751	255	28	-	-	PUNCT
gs-3751	255	29	control	control	NOUN
gs-3751	255	30	studies	study	NOUN
gs-3751	255	31	(	(	PUNCT
gs-3751	255	32	n	n	NOUN
gs-3751	255	33	=	=	SYM
gs-3751	255	34	6	6	NUM
gs-3751	255	35	)	)	PUNCT
gs-3751	255	36	.	.	PUNCT
gs-3751	256	1	sample	sample	NOUN
gs-3751	256	2	sizes	size	NOUN
gs-3751	256	3	ranged	range	VERB
gs-3751	256	4	from	from	ADP
gs-3751	256	5	50	50	NUM
gs-3751	256	6	to	to	ADP
gs-3751	256	7	1200	1200	NUM
gs-3751	256	8	,	,	PUNCT
gs-3751	256	9	of	of	ADP
gs-3751	256	10	which	which	PRON
gs-3751	256	11	15	15	NUM
gs-3751	256	12	,	,	PUNCT
gs-3751	256	13	18	18	NUM
gs-3751	256	14	,	,	PUNCT
gs-3751	256	15	and	and	CCONJ
gs-3751	256	16	14	14	NUM
gs-3751	256	17	studies	study	NOUN
gs-3751	256	18	were	be	AUX
gs-3751	256	19	performed	perform	VERB
gs-3751	256	20	in	in	ADP
gs-3751	256	21	the	the	DET
gs-3751	256	22	united	united	PROPN
gs-3751	256	23	states	states	PROPN
gs-3751	256	24	,	,	PUNCT
gs-3751	256	25	europe	europe	PROPN
gs-3751	256	26	,	,	PUNCT
gs-3751	256	27	and	and	CCONJ
gs-3751	256	28	asia	asia	PROPN
gs-3751	256	29	,	,	PUNCT
gs-3751	256	30	respectively	respectively	ADV
gs-3751	256	31	.	.	PUNCT
gs-3751	257	1	the	the	DET
gs-3751	257	2	interventions	intervention	NOUN
gs-3751	257	3	mainly	mainly	ADV
gs-3751	257	4	involved	involve	VERB
gs-3751	257	5	probiotics	probiotic	NOUN
gs-3751	257	6	(	(	PUNCT
gs-3751	257	7	n	n	NOUN
gs-3751	257	8	=	=	NUM
gs-3751	257	9	24	24	NUM
gs-3751	257	10	)	)	PUNCT
gs-3751	257	11	,	,	PUNCT
gs-3751	257	12	fecal	fecal	ADJ
gs-3751	257	13	microbiota	microbiota	NOUN
gs-3751	257	14	transplantation	transplantation	NOUN
gs-3751	257	15	(	(	PUNCT
gs-3751	257	16	fmt	fmt	NOUN
gs-3751	257	17	)	)	PUNCT
gs-3751	257	18	(	(	PUNCT
gs-3751	257	19	n	n	NOUN
gs-3751	257	20	=	=	SYM
gs-3751	257	21	7	7	NUM
gs-3751	257	22	)	)	PUNCT
gs-3751	257	23	,	,	PUNCT
gs-3751	257	24	and	and	CCONJ
gs-3751	257	25	dietary	dietary	ADJ
gs-3751	257	26	alteration	alteration	NOUN
gs-3751	257	27	(	(	PUNCT
gs-3751	257	28	n	n	NOUN
gs-3751	257	29	=	=	SYM
gs-3751	257	30	16	16	NUM
gs-3751	257	31	)	)	PUNCT
gs-3751	257	32	.	.	PUNCT
gs-3751	258	1	georgian	georgian	ADJ
gs-3751	258	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3751	258	3	მეცნიერები	მეცნიერები	NOUN
gs-3751	258	4	ტ.	ტ.	VERB
gs-3751	258	5	7	7	NUM
gs-3751	258	6	n	n	DET
gs-3751	258	7	2	2	NUM
gs-3751	258	8	,	,	PUNCT
gs-3751	258	9	2025	2025	NUM
gs-3751	258	10	344	344	NUM
gs-3751	258	11			NOUN
gs-3751	258	12	primary	primary	ADJ
gs-3751	258	13	outcomes	outcome	NOUN
gs-3751	258	14	:	:	PUNCT
gs-3751	258	15			ADJ
gs-3751	258	16	cognitive	cognitive	ADJ
gs-3751	258	17	function	function	NOUN
gs-3751	258	18	:	:	PUNCT
gs-3751	258	19	twenty	twenty	NUM
gs-3751	258	20	-	-	PUNCT
gs-3751	258	21	five	five	NUM
gs-3751	258	22	studies	study	NOUN
gs-3751	258	23	revealed	reveal	VERB
gs-3751	258	24	significant	significant	ADJ
gs-3751	258	25	cognitive	cognitive	ADJ
gs-3751	258	26	score	score	NOUN
gs-3751	258	27	improvements	improvement	NOUN
gs-3751	258	28	(	(	PUNCT
gs-3751	258	29	e.g.	e.g.	ADV
gs-3751	258	30	,	,	PUNCT
gs-3751	258	31	mmse	mmse	ADJ
gs-3751	258	32	,	,	PUNCT
gs-3751	258	33	moca	moca	PROPN
gs-3751	258	34	)	)	PUNCT
gs-3751	258	35	postmicrobiome	postmicrobiome	PROPN
gs-3751	258	36	-	-	PUNCT
gs-3751	258	37	targeted	target	VERB
gs-3751	258	38	interventions	intervention	NOUN
gs-3751	258	39	.	.	PUNCT
gs-3751	259	1	probiotic	probiotic	ADJ
gs-3751	259	2	therapy	therapy	NOUN
gs-3751	259	3	improved	improve	VERB
gs-3751	259	4	cognitive	cognitive	ADJ
gs-3751	259	5	function	function	NOUN
gs-3751	259	6	scores	score	NOUN
gs-3751	259	7	by	by	ADP
gs-3751	259	8	20%-30	20%-30	NUM
gs-3751	259	9	%	%	NOUN
gs-3751	259	10	as	as	SCONJ
gs-3751	259	11	compared	compare	VERB
gs-3751	259	12	with	with	ADP
gs-3751	259	13	the	the	DET
gs-3751	259	14	control	control	NOUN
gs-3751	259	15	studies	study	NOUN
gs-3751	259	16	.	.	PUNCT
gs-3751	260	1	fmt	fmt	PROPN
gs-3751	260	2	shows	show	VERB
gs-3751	260	3	moderate	moderate	ADJ
gs-3751	260	4	efficacy	efficacy	NOUN
gs-3751	260	5	,	,	PUNCT
gs-3751	260	6	with	with	ADP
gs-3751	260	7	three	three	NUM
gs-3751	260	8	studies	study	NOUN
gs-3751	260	9	reporting	report	VERB
gs-3751	260	10	delayed	delay	VERB
gs-3751	260	11	disease	disease	NOUN
gs-3751	260	12	progression	progression	NOUN
gs-3751	260	13	via	via	ADP
gs-3751	260	14	imaging	image	VERB
gs-3751	260	15	biomarkers	biomarker	NOUN
gs-3751	260	16	among	among	ADP
gs-3751	260	17	parkinson	parkinson	NOUN
gs-3751	260	18	's	's	PART
gs-3751	260	19	patients	patient	NOUN
gs-3751	260	20	.	.	PUNCT
gs-3751	261	1			ADJ
gs-3751	261	2	disease	disease	NOUN
gs-3751	261	3	progression	progression	NOUN
gs-3751	261	4	:	:	PUNCT
gs-3751	261	5	in	in	ADP
gs-3751	261	6	18	18	NUM
gs-3751	261	7	studies	study	NOUN
gs-3751	261	8	were	be	AUX
gs-3751	261	9	microbiome	microbiome	ADJ
gs-3751	261	10	modulation	modulation	NOUN
gs-3751	261	11	was	be	AUX
gs-3751	261	12	combined	combine	VERB
gs-3751	261	13	with	with	ADP
gs-3751	261	14	standard	standard	ADJ
gs-3751	261	15	care	care	NOUN
gs-3751	261	16	,	,	PUNCT
gs-3751	261	17	the	the	DET
gs-3751	261	18	disease	disease	NOUN
gs-3751	261	19	had	have	VERB
gs-3751	261	20	a	a	DET
gs-3751	261	21	slower	slow	ADJ
gs-3751	261	22	progression	progression	NOUN
gs-3751	261	23	compared	compare	VERB
gs-3751	261	24	to	to	ADP
gs-3751	261	25	standard	standard	ADJ
gs-3751	261	26	care	care	NOUN
gs-3751	261	27	alone	alone	ADV
gs-3751	261	28	.	.	PUNCT
gs-3751	262	1	in	in	ADP
gs-3751	262	2	15	15	NUM
gs-3751	262	3	studies	study	NOUN
gs-3751	262	4	,	,	PUNCT
gs-3751	262	5	biomarkers	biomarker	NOUN
gs-3751	262	6	confirmed	confirm	VERB
gs-3751	262	7	improvement	improvement	NOUN
gs-3751	262	8	in	in	ADP
gs-3751	262	9	symptoms	symptom	NOUN
gs-3751	262	10	with	with	ADP
gs-3751	262	11	the	the	DET
gs-3751	262	12	involvement	involvement	NOUN
gs-3751	262	13	of	of	ADP
gs-3751	262	14	amyloid	amyloid	NOUN
gs-3751	262	15	-	-	PUNCT
gs-3751	262	16	β	β	NOUN
gs-3751	262	17	load	load	NOUN
gs-3751	262	18	and	and	CCONJ
gs-3751	262	19	motor	motor	NOUN
gs-3751	262	20	activity	activity	NOUN
gs-3751	262	21	.	.	PUNCT
gs-3751	263	1			NOUN
gs-3751	263	2	secondary	secondary	ADJ
gs-3751	263	3	outcomes	outcome	NOUN
gs-3751	263	4	:	:	PUNCT
gs-3751	263	5			ADJ
gs-3751	263	6	microbiome	microbiome	ADJ
gs-3751	263	7	composition	composition	NOUN
gs-3751	263	8	:	:	PUNCT
gs-3751	263	9	increased	increase	VERB
gs-3751	263	10	microbial	microbial	ADJ
gs-3751	263	11	diversity	diversity	NOUN
gs-3751	263	12	and	and	CCONJ
gs-3751	263	13	reduced	reduce	VERB
gs-3751	263	14	pathogenic	pathogenic	ADJ
gs-3751	263	15	species	specie	NOUN
gs-3751	263	16	were	be	AUX
gs-3751	263	17	observed	observe	VERB
gs-3751	263	18	in	in	ADP
gs-3751	263	19	20	20	NUM
gs-3751	263	20	%	%	NOUN
gs-3751	263	21	of	of	ADP
gs-3751	263	22	studies	study	NOUN
gs-3751	263	23	employing	employ	VERB
gs-3751	263	24	probiotics	probiotic	NOUN
gs-3751	263	25	.	.	PUNCT
gs-3751	264	1	beneficial	beneficial	ADJ
gs-3751	264	2	strains	strain	NOUN
gs-3751	264	3	like	like	ADP
gs-3751	264	4	lactobacillus	lactobacillus	NOUN
gs-3751	264	5	and	and	CCONJ
gs-3751	264	6	bifidobacterium	bifidobacterium	NOUN
gs-3751	264	7	were	be	AUX
gs-3751	264	8	enhanced	enhance	VERB
gs-3751	264	9	to	to	ADP
gs-3751	264	10	some	some	DET
gs-3751	264	11	degree	degree	NOUN
gs-3751	264	12	by	by	ADP
gs-3751	264	13	dietary	dietary	ADJ
gs-3751	264	14	interventions	intervention	NOUN
gs-3751	264	15	.	.	PUNCT
gs-3751	265	1			ADJ
gs-3751	265	2	gut	gut	NOUN
gs-3751	265	3	-	-	PUNCT
gs-3751	265	4	brain	brain	NOUN
gs-3751	265	5	axis	axis	NOUN
gs-3751	265	6	dynamics	dynamic	NOUN
gs-3751	265	7	:	:	PUNCT
gs-3751	265	8	a	a	DET
gs-3751	265	9	decrease	decrease	NOUN
gs-3751	265	10	in	in	ADP
gs-3751	265	11	systemic	systemic	ADJ
gs-3751	265	12	inflammation	inflammation	NOUN
gs-3751	265	13	(	(	PUNCT
gs-3751	265	14	e.g.	e.g.	ADV
gs-3751	265	15	,	,	PUNCT
gs-3751	265	16	lower	low	ADJ
gs-3751	265	17	tnf	tnf	PROPN
gs-3751	265	18	-	-	PUNCT
gs-3751	265	19	α	α	PROPN
gs-3751	265	20	,	,	PUNCT
gs-3751	265	21	il-6	il-6	NUM
gs-3751	265	22	)	)	PUNCT
gs-3751	265	23	was	be	AUX
gs-3751	265	24	described	describe	VERB
gs-3751	265	25	in	in	ADP
gs-3751	265	26	22	22	NUM
gs-3751	265	27	studies	study	NOUN
gs-3751	265	28	.	.	PUNCT
gs-3751	266	1	improved	improve	VERB
gs-3751	266	2	neurotransmitter	neurotransmitter	NOUN
gs-3751	266	3	balance	balance	NOUN
gs-3751	266	4	(	(	PUNCT
gs-3751	266	5	increased	increase	VERB
gs-3751	266	6	serotonin	serotonin	NOUN
gs-3751	266	7	,	,	PUNCT
gs-3751	266	8	dopamine	dopamine	NOUN
gs-3751	266	9	)	)	PUNCT
gs-3751	266	10	was	be	AUX
gs-3751	266	11	also	also	ADV
gs-3751	266	12	demonstrated	demonstrate	VERB
gs-3751	266	13	in	in	ADP
gs-3751	266	14	12	12	NUM
gs-3751	266	15	studies	study	NOUN
gs-3751	266	16	.	.	PUNCT
gs-3751	267	1	georgian	georgian	ADJ
gs-3751	267	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3751	267	3	მეცნიერები	მეცნიერები	NOUN
gs-3751	267	4	ტ.	ტ.	VERB
gs-3751	267	5	7	7	NUM
gs-3751	267	6	n	n	DET
gs-3751	267	7	2	2	NUM
gs-3751	267	8	,	,	PUNCT
gs-3751	267	9	2025	2025	NUM
gs-3751	267	10	345	345	NUM
gs-3751	267	11	the	the	DET
gs-3751	267	12	findings	finding	NOUN
gs-3751	267	13	of	of	ADP
gs-3751	267	14	this	this	DET
gs-3751	267	15	systematic	systematic	ADJ
gs-3751	267	16	review	review	NOUN
gs-3751	267	17	imply	imply	VERB
gs-3751	267	18	that	that	SCONJ
gs-3751	267	19	it	it	PRON
gs-3751	267	20	may	may	AUX
gs-3751	267	21	provide	provide	VERB
gs-3751	267	22	beneficial	beneficial	ADJ
gs-3751	267	23	effects	effect	NOUN
gs-3751	267	24	on	on	ADP
gs-3751	267	25	cognitive	cognitive	ADJ
gs-3751	267	26	performance	performance	NOUN
gs-3751	267	27	and	and	CCONJ
gs-3751	267	28	disease	disease	NOUN
gs-3751	267	29	progression	progression	NOUN
gs-3751	267	30	when	when	SCONJ
gs-3751	267	31	targeted	target	VERB
gs-3751	267	32	interventions	intervention	NOUN
gs-3751	267	33	aimed	aim	VERB
gs-3751	267	34	at	at	ADP
gs-3751	267	35	gut	gut	NOUN
gs-3751	267	36	microbiota	microbiota	NOUN
gs-3751	267	37	are	be	AUX
gs-3751	267	38	combined	combine	VERB
gs-3751	267	39	with	with	ADP
gs-3751	267	40	standard	standard	ADJ
gs-3751	267	41	treatments	treatment	NOUN
gs-3751	267	42	in	in	ADP
gs-3751	267	43	alzheimer	alzheimer	PROPN
gs-3751	267	44	's	's	PART
gs-3751	267	45	and	and	CCONJ
gs-3751	267	46	parkinson	parkinson	NOUN
gs-3751	267	47	's	's	PART
gs-3751	267	48	diseases	disease	NOUN
gs-3751	267	49	.	.	PUNCT
gs-3751	268	1			ADJ
gs-3751	268	2	cognitive	cognitive	ADJ
gs-3751	268	3	improvements	improvement	NOUN
gs-3751	268	4	:	:	PUNCT
gs-3751	268	5	there	there	PRON
gs-3751	268	6	is	be	VERB
gs-3751	268	7	concrete	concrete	ADJ
gs-3751	268	8	evidence	evidence	NOUN
gs-3751	268	9	for	for	ADP
gs-3751	268	10	probiotic	probiotic	ADJ
gs-3751	268	11	supplementation	supplementation	NOUN
gs-3751	268	12	producing	produce	VERB
gs-3751	268	13	more	more	ADV
gs-3751	268	14	favorable	favorable	ADJ
gs-3751	268	15	cognitive	cognitive	ADJ
gs-3751	268	16	outcomes	outcome	NOUN
gs-3751	268	17	across	across	ADP
gs-3751	268	18	different	different	ADJ
gs-3751	268	19	human	human	ADJ
gs-3751	268	20	populations	population	NOUN
gs-3751	268	21	.	.	PUNCT
gs-3751	269	1	these	these	DET
gs-3751	269	2	changes	change	NOUN
gs-3751	269	3	were	be	AUX
gs-3751	269	4	probably	probably	ADV
gs-3751	269	5	mediated	mediate	VERB
gs-3751	269	6	by	by	ADP
gs-3751	269	7	mechanisms	mechanism	NOUN
gs-3751	269	8	which	which	PRON
gs-3751	269	9	involve	involve	VERB
gs-3751	269	10	reduction	reduction	NOUN
gs-3751	269	11	of	of	ADP
gs-3751	269	12	neuroinflammation	neuroinflammation	NOUN
gs-3751	269	13	and	and	CCONJ
gs-3751	269	14	increasing	increase	VERB
gs-3751	269	15	the	the	DET
gs-3751	269	16	synthesis	synthesis	NOUN
gs-3751	269	17	of	of	ADP
gs-3751	269	18	neurotransmitters	neurotransmitter	NOUN
gs-3751	269	19	such	such	ADJ
gs-3751	269	20	as	as	ADP
gs-3751	269	21	dopamine	dopamine	NOUN
gs-3751	269	22	and	and	CCONJ
gs-3751	269	23	serotonin	serotonin	NOUN
gs-3751	269	24	.	.	PUNCT
gs-3751	270	1	multiple	multiple	ADJ
gs-3751	270	2	studies	study	NOUN
gs-3751	270	3	that	that	PRON
gs-3751	270	4	have	have	AUX
gs-3751	270	5	been	be	AUX
gs-3751	270	6	conducted	conduct	VERB
gs-3751	270	7	have	have	AUX
gs-3751	270	8	shown	show	VERB
gs-3751	270	9	an	an	DET
gs-3751	270	10	improvement	improvement	NOUN
gs-3751	270	11	in	in	ADP
gs-3751	270	12	cognitive	cognitive	ADJ
gs-3751	270	13	scores	score	NOUN
gs-3751	270	14	of	of	ADP
gs-3751	270	15	individuals	individual	NOUN
gs-3751	270	16	as	as	ADV
gs-3751	270	17	high	high	ADJ
gs-3751	270	18	as	as	ADP
gs-3751	270	19	30	30	NUM
gs-3751	270	20	%	%	NOUN
gs-3751	270	21	.	.	PUNCT
gs-3751	271	1	this	this	PRON
gs-3751	271	2	is	be	AUX
gs-3751	271	3	also	also	ADV
gs-3751	271	4	consistent	consistent	ADJ
gs-3751	271	5	with	with	ADP
gs-3751	271	6	previous	previous	ADJ
gs-3751	271	7	research	research	NOUN
gs-3751	271	8	that	that	PRON
gs-3751	271	9	suggests	suggest	VERB
gs-3751	271	10	a	a	DET
gs-3751	271	11	good	good	ADJ
gs-3751	271	12	healthy	healthy	ADJ
gs-3751	271	13	microbiome	microbiome	NOUN
gs-3751	271	14	of	of	ADP
gs-3751	271	15	the	the	DET
gs-3751	271	16	gut	gut	NOUN
gs-3751	271	17	can	can	AUX
gs-3751	271	18	positively	positively	ADV
gs-3751	271	19	influence	influence	VERB
gs-3751	271	20	the	the	DET
gs-3751	271	21	central	central	ADJ
gs-3751	271	22	nervous	nervous	ADJ
gs-3751	271	23	system	system	NOUN
gs-3751	271	24	.	.	PUNCT
gs-3751	272	1			ADJ
gs-3751	272	2	slowing	slow	VERB
gs-3751	272	3	disease	disease	NOUN
gs-3751	272	4	progression	progression	NOUN
gs-3751	272	5	:	:	PUNCT
gs-3751	272	6	alteration	alteration	NOUN
gs-3751	272	7	of	of	ADP
gs-3751	272	8	the	the	DET
gs-3751	272	9	gut	gut	NOUN
gs-3751	272	10	microbiota	microbiota	NOUN
gs-3751	272	11	via	via	ADP
gs-3751	272	12	dietary	dietary	ADJ
gs-3751	272	13	modifications	modification	NOUN
gs-3751	272	14	and	and	CCONJ
gs-3751	272	15	fmt	fmt	NOUN
gs-3751	272	16	appears	appear	VERB
gs-3751	272	17	to	to	PART
gs-3751	272	18	delay	delay	VERB
gs-3751	272	19	disease	disease	NOUN
gs-3751	272	20	progression	progression	NOUN
gs-3751	272	21	,	,	PUNCT
gs-3751	272	22	with	with	ADP
gs-3751	272	23	improvement	improvement	NOUN
gs-3751	272	24	in	in	ADP
gs-3751	272	25	motor	motor	NOUN
gs-3751	272	26	and	and	CCONJ
gs-3751	272	27	non	non	ADJ
gs-3751	272	28	-	-	ADJ
gs-3751	272	29	motor	motor	ADJ
gs-3751	272	30	symptoms	symptom	NOUN
gs-3751	272	31	in	in	ADP
gs-3751	272	32	pd	pd	NOUN
gs-3751	272	33	and	and	CCONJ
gs-3751	272	34	attenuation	attenuation	NOUN
gs-3751	272	35	of	of	ADP
gs-3751	272	36	amyloidβ	amyloidβ	NOUN
gs-3751	272	37	and	and	CCONJ
gs-3751	272	38	tau	tau	PROPN
gs-3751	272	39	pathology	pathology	NOUN
gs-3751	272	40	in	in	ADP
gs-3751	272	41	ad	ad	NOUN
gs-3751	272	42	.	.	PUNCT
gs-3751	273	1			ADJ
gs-3751	273	2	comparison	comparison	NOUN
gs-3751	273	3	with	with	ADP
gs-3751	273	4	standard	standard	ADJ
gs-3751	273	5	treatments	treatment	NOUN
gs-3751	273	6	:	:	PUNCT
gs-3751	273	7	standard	standard	ADJ
gs-3751	273	8	treatment	treatment	NOUN
gs-3751	273	9	involves	involve	VERB
gs-3751	273	10	levodopa	levodopa	NOUN
gs-3751	273	11	,	,	PUNCT
gs-3751	273	12	cholinesterase	cholinesterase	NOUN
gs-3751	273	13	inhibitors	inhibitor	NOUN
gs-3751	273	14	and	and	CCONJ
gs-3751	273	15	so	so	ADV
gs-3751	273	16	on	on	ADV
gs-3751	273	17	.	.	PUNCT
gs-3751	274	1	they	they	PRON
gs-3751	274	2	serve	serve	VERB
gs-3751	274	3	as	as	ADP
gs-3751	274	4	the	the	DET
gs-3751	274	5	primary	primary	ADJ
gs-3751	274	6	treatment	treatment	NOUN
gs-3751	274	7	for	for	ADP
gs-3751	274	8	managing	manage	VERB
gs-3751	274	9	the	the	DET
gs-3751	274	10	symptoms	symptom	NOUN
gs-3751	274	11	of	of	ADP
gs-3751	274	12	neurodegenerative	neurodegenerative	ADJ
gs-3751	274	13	diseases	disease	NOUN
gs-3751	274	14	such	such	ADJ
gs-3751	274	15	as	as	ADP
gs-3751	274	16	alzheimer	alzheimer	NOUN
gs-3751	274	17	’s	’s	PART
gs-3751	274	18	and	and	CCONJ
gs-3751	274	19	parkinsons	parkinson	NOUN
gs-3751	274	20	.	.	PUNCT
gs-3751	275	1	targeted	target	VERB
gs-3751	275	2	microbiome	microbiome	NOUN
gs-3751	275	3	therapy	therapy	NOUN
gs-3751	275	4	along	along	ADP
gs-3751	275	5	with	with	ADP
gs-3751	275	6	use	use	NOUN
gs-3751	275	7	of	of	ADP
gs-3751	275	8	dietary	dietary	ADJ
gs-3751	275	9	modifications	modification	NOUN
gs-3751	275	10	which	which	PRON
gs-3751	275	11	include	include	VERB
gs-3751	275	12	prebiotics	prebiotic	NOUN
gs-3751	275	13	,	,	PUNCT
gs-3751	275	14	probiotics	probiotic	NOUN
gs-3751	275	15	and	and	CCONJ
gs-3751	275	16	transplantation	transplantation	NOUN
gs-3751	275	17	of	of	ADP
gs-3751	275	18	fecal	fecal	ADJ
gs-3751	275	19	microbiota	microbiota	NOUN
gs-3751	275	20	can	can	AUX
gs-3751	275	21	have	have	AUX
gs-3751	275	22	ameliorating	ameliorate	VERB
gs-3751	275	23	effects	effect	NOUN
gs-3751	275	24	which	which	PRON
gs-3751	275	25	include	include	VERB
gs-3751	275	26	working	work	VERB
gs-3751	275	27	on	on	ADP
gs-3751	275	28	the	the	DET
gs-3751	275	29	underlying	underlying	ADJ
gs-3751	275	30	mechanism	mechanism	NOUN
gs-3751	275	31	of	of	ADP
gs-3751	275	32	the	the	DET
gs-3751	275	33	inflammation	inflammation	NOUN
gs-3751	275	34	and	and	CCONJ
gs-3751	275	35	metabolic	metabolic	NOUN
gs-3751	275	36	dysregulation	dysregulation	NOUN
gs-3751	275	37	by	by	ADP
gs-3751	275	38	enhancing	enhance	VERB
gs-3751	275	39	the	the	DET
gs-3751	275	40	efficacy	efficacy	NOUN
gs-3751	275	41	of	of	ADP
gs-3751	275	42	standard	standard	ADJ
gs-3751	275	43	treatment	treatment	NOUN
gs-3751	275	44	.	.	PUNCT
gs-3751	276	1	anti	anti	ADJ
gs-3751	276	2	-	-	ADJ
gs-3751	276	3	inflammatory	inflammatory	ADJ
gs-3751	276	4	and	and	CCONJ
gs-3751	276	5	neuroprotective	neuroprotective	ADJ
gs-3751	276	6	properties	property	NOUN
gs-3751	276	7	are	be	AUX
gs-3751	276	8	observed	observe	VERB
gs-3751	276	9	in	in	ADP
gs-3751	276	10	probiotics	probiotic	NOUN
gs-3751	276	11	and	and	CCONJ
gs-3751	276	12	prebiotics	prebiotic	NOUN
gs-3751	276	13	but	but	CCONJ
gs-3751	276	14	given	give	VERB
gs-3751	276	15	the	the	DET
gs-3751	276	16	limited	limit	VERB
gs-3751	276	17	amount	amount	NOUN
gs-3751	276	18	of	of	ADP
gs-3751	276	19	evidence	evidence	NOUN
gs-3751	276	20	being	be	AUX
gs-3751	276	21	present	present	ADJ
gs-3751	276	22	,	,	PUNCT
gs-3751	276	23	it	it	PRON
gs-3751	276	24	would	would	AUX
gs-3751	276	25	be	be	AUX
gs-3751	276	26	too	too	ADV
gs-3751	276	27	early	early	ADJ
gs-3751	276	28	to	to	PART
gs-3751	276	29	consider	consider	VERB
gs-3751	276	30	using	use	VERB
gs-3751	276	31	them	they	PRON
gs-3751	276	32	as	as	ADP
gs-3751	276	33	just	just	ADV
gs-3751	276	34	standalone	standalone	ADJ
gs-3751	276	35	therapies	therapy	NOUN
gs-3751	276	36	.	.	PUNCT
gs-3751	277	1	the	the	DET
gs-3751	277	2	gut	gut	NOUN
gs-3751	277	3	-	-	PUNCT
gs-3751	277	4	brain	brain	NOUN
gs-3751	277	5	axis	axis	NOUN
gs-3751	277	6	is	be	AUX
gs-3751	277	7	a	a	DET
gs-3751	277	8	linchpin	linchpin	NOUN
gs-3751	277	9	in	in	ADP
gs-3751	277	10	neurodegenerative	neurodegenerative	ADJ
gs-3751	277	11	disease	disease	NOUN
gs-3751	277	12	,	,	PUNCT
gs-3751	277	13	offering	offer	VERB
gs-3751	277	14	unprecedented	unprecedented	ADJ
gs-3751	277	15	opportunities	opportunity	NOUN
gs-3751	277	16	for	for	ADP
gs-3751	277	17	intervention	intervention	NOUN
gs-3751	277	18	.	.	PUNCT
gs-3751	278	1	while	while	SCONJ
gs-3751	278	2	probiotics	probiotic	NOUN
gs-3751	278	3	,	,	PUNCT
gs-3751	278	4	fmt	fmt	NOUN
gs-3751	278	5	,	,	PUNCT
gs-3751	278	6	and	and	CCONJ
gs-3751	278	7	metabolite	metabolite	NOUN
gs-3751	278	8	inhibitors	inhibitor	NOUN
gs-3751	278	9	show	show	VERB
gs-3751	278	10	promise	promise	NOUN
gs-3751	278	11	,	,	PUNCT
gs-3751	278	12	their	their	PRON
gs-3751	278	13	success	success	NOUN
gs-3751	278	14	hinges	hinge	VERB
gs-3751	278	15	on	on	ADP
gs-3751	278	16	precision	precision	NOUN
gs-3751	278	17	medicine	medicine	NOUN
gs-3751	278	18	approaches	approach	NOUN
gs-3751	278	19	that	that	PRON
gs-3751	278	20	account	account	VERB
gs-3751	278	21	for	for	ADP
gs-3751	278	22	individual	individual	ADJ
gs-3751	278	23	microbiome	microbiome	NOUN
gs-3751	278	24	signatures	signature	NOUN
gs-3751	278	25	.	.	PUNCT
gs-3751	279	1	future	future	ADJ
gs-3751	279	2	research	research	NOUN
gs-3751	279	3	must	must	AUX
gs-3751	279	4	bridge	bridge	VERB
gs-3751	279	5	gaps	gap	NOUN
gs-3751	279	6	between	between	ADP
gs-3751	279	7	animal	animal	NOUN
gs-3751	279	8	models	model	NOUN
gs-3751	279	9	and	and	CCONJ
gs-3751	279	10	human	human	ADJ
gs-3751	279	11	trials	trial	NOUN
gs-3751	279	12	,	,	PUNCT
gs-3751	279	13	prioritize	prioritize	VERB
gs-3751	279	14	sex	sex	NOUN
gs-3751	279	15	-	-	PUNCT
gs-3751	279	16	specific	specific	ADJ
gs-3751	279	17	analyses	analysis	NOUN
gs-3751	279	18	,	,	PUNCT
gs-3751	279	19	and	and	CCONJ
gs-3751	279	20	leverage	leverage	NOUN
gs-3751	279	21	ai	ai	VERB
gs-3751	279	22	for	for	ADP
gs-3751	279	23	microbiome	microbiome	NOUN
gs-3751	279	24	decoding	decoding	NOUN
gs-3751	279	25	.	.	PUNCT
gs-3751	280	1	by	by	ADP
gs-3751	280	2	targeting	target	VERB
gs-3751	280	3	the	the	DET
gs-3751	280	4	gba	gba	NOUN
gs-3751	280	5	,	,	PUNCT
gs-3751	280	6	we	we	PRON
gs-3751	280	7	may	may	AUX
gs-3751	280	8	transform	transform	VERB
gs-3751	280	9	neurodegenerative	neurodegenerative	ADJ
gs-3751	280	10	disease	disease	NOUN
gs-3751	280	11	management	management	NOUN
gs-3751	280	12	from	from	ADP
gs-3751	280	13	reactive	reactive	NOUN
gs-3751	280	14	to	to	ADP
gs-3751	280	15	proactive	proactive	ADJ
gs-3751	280	16	,	,	PUNCT
gs-3751	280	17	delaying	delaying	NOUN
gs-3751	280	18	—	—	PUNCT
gs-3751	280	19	or	or	CCONJ
gs-3751	280	20	even	even	ADV
gs-3751	280	21	preventing	prevent	VERB
gs-3751	280	22	—	—	PUNCT
gs-3751	280	23	pathology	pathology	NOUN
gs-3751	280	24	before	before	SCONJ
gs-3751	280	25	cns	cns	PROPN
gs-3751	280	26	symptoms	symptom	NOUN
gs-3751	280	27	emerge	emerge	VERB
gs-3751	280	28	.	.	PUNCT
gs-3751	281	1	ethical	ethical	ADJ
gs-3751	281	2	and	and	CCONJ
gs-3751	281	3	societal	societal	ADJ
gs-3751	281	4	considerations	consideration	NOUN
gs-3751	281	5	loom	loom	VERB
gs-3751	281	6	large	large	ADJ
gs-3751	281	7	in	in	ADP
gs-3751	281	8	the	the	DET
gs-3751	281	9	commercialization	commercialization	NOUN
gs-3751	281	10	of	of	ADP
gs-3751	281	11	gba	gba	NOUN
gs-3751	281	12	therapies	therapy	NOUN
gs-3751	281	13	.	.	PUNCT
gs-3751	282	1	the	the	DET
gs-3751	282	2	rise	rise	NOUN
gs-3751	282	3	of	of	ADP
gs-3751	282	4	direct	direct	ADJ
gs-3751	282	5	-	-	PUNCT
gs-3751	282	6	to	to	ADP
gs-3751	282	7	-	-	PUNCT
gs-3751	282	8	consumer	consumer	NOUN
gs-3751	282	9	microbiome	microbiome	NOUN
gs-3751	282	10	testing	testing	NOUN
gs-3751	282	11	kits	kit	NOUN
gs-3751	282	12	,	,	PUNCT
gs-3751	282	13	while	while	SCONJ
gs-3751	282	14	empowering	empower	VERB
gs-3751	282	15	patients	patient	NOUN
gs-3751	282	16	,	,	PUNCT
gs-3751	282	17	risks	risk	NOUN
gs-3751	282	18	misinterpretation	misinterpretation	NOUN
gs-3751	282	19	of	of	ADP
gs-3751	282	20	complex	complex	ADJ
gs-3751	282	21	data	datum	NOUN
gs-3751	282	22	without	without	ADP
gs-3751	282	23	clinician	clinician	NOUN
gs-3751	282	24	guidance	guidance	NOUN
gs-3751	282	25	.	.	PUNCT
gs-3751	283	1	a	a	DET
gs-3751	283	2	consumer	consumer	NOUN
gs-3751	283	3	might	might	AUX
gs-3751	283	4	inappropriately	inappropriately	ADV
gs-3751	283	5	self	self	NOUN
gs-3751	283	6	-	-	PUNCT
gs-3751	283	7	prescribe	prescribe	NOUN
gs-3751	283	8	probiotics	probiotic	NOUN
gs-3751	283	9	after	after	ADP
gs-3751	283	10	misreading	misread	VERB
gs-3751	283	11	a	a	DET
gs-3751	283	12	proteobacteria	proteobacteria	NOUN
gs-3751	283	13	elevation	elevation	NOUN
gs-3751	283	14	as	as	ADP
gs-3751	283	15	pathogenic	pathogenic	ADJ
gs-3751	283	16	,	,	PUNCT
gs-3751	283	17	unaware	unaware	ADJ
gs-3751	283	18	that	that	SCONJ
gs-3751	283	19	context	context	NOUN
gs-3751	283	20	(	(	PUNCT
gs-3751	283	21	e.g.	e.g.	ADV
gs-3751	283	22	,	,	PUNCT
gs-3751	283	23	recent	recent	ADJ
gs-3751	283	24	antibiotic	antibiotic	ADJ
gs-3751	283	25	use	use	NOUN
gs-3751	283	26	)	)	PUNCT
gs-3751	283	27	alters	alter	VERB
gs-3751	283	28	clinical	clinical	ADJ
gs-3751	283	29	significance	significance	NOUN
gs-3751	283	30	.	.	PUNCT
gs-3751	284	1	similarly	similarly	ADV
gs-3751	284	2	,	,	PUNCT
gs-3751	284	3	the	the	DET
gs-3751	284	4	high	high	ADJ
gs-3751	284	5	cost	cost	NOUN
gs-3751	284	6	of	of	ADP
gs-3751	284	7	personalized	personalized	ADJ
gs-3751	284	8	therapies	therapy	NOUN
gs-3751	284	9	like	like	ADP
gs-3751	284	10	crispr	crispr	NOUN
gs-3751	284	11	-	-	PUNCT
gs-3751	284	12	edited	edit	VERB
gs-3751	284	13	probiotics	probiotic	NOUN
gs-3751	284	14	or	or	CCONJ
gs-3751	284	15	fmt	fmt	NOUN
gs-3751	284	16	could	could	AUX
gs-3751	284	17	exacerbate	exacerbate	VERB
gs-3751	284	18	healthcare	healthcare	NOUN
gs-3751	284	19	disparities	disparity	NOUN
gs-3751	284	20	,	,	PUNCT
gs-3751	284	21	particularly	particularly	ADV
gs-3751	284	22	in	in	ADP
gs-3751	284	23	low	low	ADJ
gs-3751	284	24	-	-	PUNCT
gs-3751	284	25	income	income	NOUN
gs-3751	284	26	regions	region	NOUN
gs-3751	284	27	where	where	SCONJ
gs-3751	284	28	traditional	traditional	ADJ
gs-3751	284	29	fermented	ferment	VERB
gs-3751	284	30	foods	food	NOUN
gs-3751	284	31	(	(	PUNCT
gs-3751	284	32	e.g.	e.g.	ADV
gs-3751	284	33	,	,	PUNCT
gs-3751	284	34	kimchi	kimchi	NOUN
gs-3751	284	35	,	,	PUNCT
gs-3751	284	36	kefir	kefir	PROPN
gs-3751	284	37	)	)	PUNCT
gs-3751	284	38	offer	offer	VERB
gs-3751	284	39	affordable	affordable	ADJ
gs-3751	284	40	alternatives	alternative	NOUN
gs-3751	284	41	.	.	PUNCT
gs-3751	285	1	regulatory	regulatory	ADJ
gs-3751	285	2	frameworks	framework	NOUN
gs-3751	285	3	must	must	AUX
gs-3751	285	4	evolve	evolve	VERB
gs-3751	285	5	to	to	PART
gs-3751	285	6	ensure	ensure	VERB
gs-3751	285	7	equitable	equitable	ADJ
gs-3751	285	8	access	access	NOUN
gs-3751	285	9	,	,	PUNCT
gs-3751	285	10	enforce	enforce	VERB
gs-3751	285	11	transparency	transparency	NOUN
gs-3751	285	12	in	in	ADP
gs-3751	285	13	probiotic	probiotic	ADJ
gs-3751	285	14	labeling	labeling	NOUN
gs-3751	285	15	,	,	PUNCT
gs-3751	285	16	and	and	CCONJ
gs-3751	285	17	mitigate	mitigate	VERB
gs-3751	285	18	risks	risk	NOUN
gs-3751	285	19	of	of	ADP
gs-3751	285	20	microbiome	microbiome	NOUN
gs-3751	285	21	-	-	PUNCT
gs-3751	285	22	related	relate	VERB
gs-3751	285	23	interventions	intervention	NOUN
gs-3751	285	24	.	.	PUNCT
gs-3751	286	1	public	public	ADJ
gs-3751	286	2	education	education	NOUN
gs-3751	286	3	campaigns	campaign	NOUN
gs-3751	286	4	,	,	PUNCT
gs-3751	286	5	co	co	VERB
gs-3751	286	6	-	-	VERB
gs-3751	286	7	developed	develop	VERB
gs-3751	286	8	with	with	ADP
gs-3751	286	9	georgian	georgian	ADJ
gs-3751	286	10	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3751	286	11	მეცნიერები	მეცნიერები	NOUN
gs-3751	286	12	ტ.	ტ.	VERB
gs-3751	286	13	7	7	NUM
gs-3751	286	14	n	n	DET
gs-3751	286	15	2	2	NUM
gs-3751	286	16	,	,	PUNCT
gs-3751	286	17	2025	2025	NUM
gs-3751	286	18	346	346	NUM
gs-3751	286	19	patient	patient	ADJ
gs-3751	286	20	advocacy	advocacy	NOUN
gs-3751	286	21	groups	group	NOUN
gs-3751	286	22	,	,	PUNCT
gs-3751	286	23	are	be	AUX
gs-3751	286	24	essential	essential	ADJ
gs-3751	286	25	to	to	PART
gs-3751	286	26	demystify	demystify	VERB
gs-3751	286	27	the	the	DET
gs-3751	286	28	gut	gut	NOUN
gs-3751	286	29	-	-	PUNCT
gs-3751	286	30	brain	brain	NOUN
gs-3751	286	31	connection	connection	NOUN
gs-3751	286	32	and	and	CCONJ
gs-3751	286	33	counter	counter	ADJ
gs-3751	286	34	pseudoscientific	pseudoscientific	ADJ
gs-3751	286	35	claims	claim	NOUN
gs-3751	286	36	proliferating	proliferate	VERB
gs-3751	286	37	in	in	ADP
gs-3751	286	38	wellness	wellness	NOUN
gs-3751	286	39	industries	industry	NOUN
gs-3751	286	40	.	.	PUNCT
gs-3751	287	1	the	the	DET
gs-3751	287	2	road	road	NOUN
gs-3751	287	3	ahead	ahead	ADV
gs-3751	287	4	demands	demand	VERB
gs-3751	287	5	collaborative	collaborative	ADJ
gs-3751	287	6	,	,	PUNCT
gs-3751	287	7	interdisciplinary	interdisciplinary	ADJ
gs-3751	287	8	efforts	effort	NOUN
gs-3751	287	9	to	to	PART
gs-3751	287	10	unravel	unravel	VERB
gs-3751	287	11	the	the	DET
gs-3751	287	12	gba	gba	NOUN
gs-3751	287	13	’s	’s	PART
gs-3751	287	14	intricacies	intricacy	NOUN
gs-3751	287	15	.	.	PUNCT
gs-3751	288	1	neurologists	neurologist	NOUN
gs-3751	288	2	,	,	PUNCT
gs-3751	288	3	microbiologists	microbiologist	NOUN
gs-3751	288	4	,	,	PUNCT
gs-3751	288	5	immunologists	immunologist	NOUN
gs-3751	288	6	,	,	PUNCT
gs-3751	288	7	and	and	CCONJ
gs-3751	288	8	data	datum	NOUN
gs-3751	288	9	scientists	scientist	NOUN
gs-3751	288	10	must	must	AUX
gs-3751	288	11	converge	converge	VERB
gs-3751	288	12	to	to	PART
gs-3751	288	13	design	design	VERB
gs-3751	288	14	studies	study	NOUN
gs-3751	288	15	that	that	PRON
gs-3751	288	16	transcend	transcend	VERB
gs-3751	288	17	disciplinary	disciplinary	ADJ
gs-3751	288	18	silos	silo	NOUN
gs-3751	288	19	.	.	PUNCT
gs-3751	289	1	longitudinal	longitudinal	ADJ
gs-3751	289	2	cohorts	cohort	NOUN
gs-3751	289	3	like	like	ADP
gs-3751	289	4	the	the	DET
gs-3751	289	5	alzheimer	alzheimer	PROPN
gs-3751	289	6	’s	’s	PART
gs-3751	289	7	gut	gut	NOUN
gs-3751	289	8	microbiome	microbiome	NOUN
gs-3751	289	9	project	project	NOUN
gs-3751	289	10	(	(	PUNCT
gs-3751	289	11	agmp	agmp	PROPN
gs-3751	289	12	)	)	PUNCT
gs-3751	289	13	,	,	PUNCT
gs-3751	289	14	which	which	PRON
gs-3751	289	15	tracks	track	VERB
gs-3751	289	16	microbial	microbial	ADJ
gs-3751	289	17	and	and	CCONJ
gs-3751	289	18	metabolomic	metabolomic	ADJ
gs-3751	289	19	changes	change	NOUN
gs-3751	289	20	across	across	ADP
gs-3751	289	21	disease	disease	NOUN
gs-3751	289	22	stages	stage	NOUN
gs-3751	289	23	,	,	PUNCT
gs-3751	289	24	are	be	AUX
gs-3751	289	25	critical	critical	ADJ
gs-3751	289	26	for	for	ADP
gs-3751	289	27	mapping	map	VERB
gs-3751	289	28	temporal	temporal	ADJ
gs-3751	289	29	dynamics	dynamic	NOUN
gs-3751	289	30	of	of	ADP
gs-3751	289	31	dysbiosis	dysbiosis	NOUN
gs-3751	289	32	.	.	PUNCT
gs-3751	290	1	concurrently	concurrently	ADV
gs-3751	290	2	,	,	PUNCT
gs-3751	290	3	advances	advance	NOUN
gs-3751	290	4	in	in	ADP
gs-3751	290	5	neuroimaging	neuroimaging	NOUN
gs-3751	290	6	—	—	PUNCT
gs-3751	290	7	such	such	ADJ
gs-3751	290	8	as	as	ADP
gs-3751	290	9	tau	tau	NOUN
gs-3751	290	10	-	-	PUNCT
gs-3751	290	11	pet	pet	ADJ
gs-3751	290	12	scans	scan	NOUN
gs-3751	290	13	in	in	ADP
gs-3751	290	14	ad	ad	NOUN
gs-3751	290	15	or	or	CCONJ
gs-3751	290	16	gut	gut	NOUN
gs-3751	290	17	-	-	PUNCT
gs-3751	290	18	specific	specific	ADJ
gs-3751	290	19	α	α	NOUN
gs-3751	290	20	-	-	PUNCT
gs-3751	290	21	synuclein	synuclein	NOUN
gs-3751	290	22	tracers	tracer	NOUN
gs-3751	290	23	in	in	ADP
gs-3751	290	24	pd	pd	PROPN
gs-3751	290	25	—	—	PUNCT
gs-3751	290	26	could	could	AUX
gs-3751	290	27	correlate	correlate	VERB
gs-3751	290	28	microbial	microbial	ADJ
gs-3751	290	29	shifts	shift	NOUN
gs-3751	290	30	with	with	ADP
gs-3751	290	31	real	real	ADJ
gs-3751	290	32	-	-	PUNCT
gs-3751	290	33	time	time	NOUN
gs-3751	290	34	brain	brain	NOUN
gs-3751	290	35	pathology	pathology	NOUN
gs-3751	290	36	.	.	PUNCT
gs-3751	291	1	the	the	DET
gs-3751	291	2	development	development	NOUN
gs-3751	291	3	of	of	ADP
gs-3751	291	4	organ	organ	NOUN
gs-3751	291	5	-	-	PUNCT
gs-3751	291	6	on	on	ADP
gs-3751	291	7	-	-	PUNCT
gs-3751	291	8	chip	chip	NOUN
gs-3751	291	9	models	model	NOUN
gs-3751	291	10	,	,	PUNCT
gs-3751	291	11	integrating	integrate	VERB
gs-3751	291	12	human	human	ADJ
gs-3751	291	13	neurons	neuron	NOUN
gs-3751	291	14	,	,	PUNCT
gs-3751	291	15	gut	gut	NOUN
gs-3751	291	16	epithelium	epithelium	NOUN
gs-3751	291	17	,	,	PUNCT
gs-3751	291	18	and	and	CCONJ
gs-3751	291	19	microbiota	microbiota	NOUN
gs-3751	291	20	,	,	PUNCT
gs-3751	291	21	may	may	AUX
gs-3751	291	22	further	far	ADV
gs-3751	291	23	bridge	bridge	VERB
gs-3751	291	24	the	the	DET
gs-3751	291	25	gap	gap	NOUN
gs-3751	291	26	between	between	ADP
gs-3751	291	27	in	in	ADP
gs-3751	291	28	vitro	vitro	X
gs-3751	291	29	findings	finding	NOUN
gs-3751	291	30	and	and	CCONJ
gs-3751	291	31	clinical	clinical	ADJ
gs-3751	291	32	applications	application	NOUN
gs-3751	291	33	.	.	PUNCT
gs-3751	292	1	ultimately	ultimately	ADV
gs-3751	292	2	,	,	PUNCT
gs-3751	292	3	the	the	DET
gs-3751	292	4	gba	gba	NOUN
gs-3751	292	5	paradigm	paradigm	NOUN
gs-3751	292	6	compels	compel	VERB
gs-3751	292	7	a	a	DET
gs-3751	292	8	reimagining	reimagining	NOUN
gs-3751	292	9	of	of	ADP
gs-3751	292	10	neurodegenerative	neurodegenerative	ADJ
gs-3751	292	11	diseases	disease	NOUN
gs-3751	292	12	as	as	ADP
gs-3751	292	13	systemic	systemic	ADJ
gs-3751	292	14	disorders	disorder	NOUN
gs-3751	292	15	rooted	root	VERB
gs-3751	292	16	in	in	ADP
gs-3751	292	17	lifelong	lifelong	ADJ
gs-3751	292	18	interactions	interaction	NOUN
gs-3751	292	19	between	between	ADP
gs-3751	292	20	genes	gene	NOUN
gs-3751	292	21	,	,	PUNCT
gs-3751	292	22	environment	environment	NOUN
gs-3751	292	23	,	,	PUNCT
gs-3751	292	24	and	and	CCONJ
gs-3751	292	25	microbes	microbe	NOUN
gs-3751	292	26	.	.	PUNCT
gs-3751	293	1	while	while	SCONJ
gs-3751	293	2	challenges	challenge	NOUN
gs-3751	293	3	persist	persist	VERB
gs-3751	293	4	—	—	PUNCT
gs-3751	293	5	from	from	ADP
gs-3751	293	6	mechanistic	mechanistic	ADJ
gs-3751	293	7	ambiguities	ambiguity	NOUN
gs-3751	293	8	to	to	ADP
gs-3751	293	9	ethical	ethical	ADJ
gs-3751	293	10	dilemmas	dilemma	NOUN
gs-3751	293	11	—	—	PUNCT
gs-3751	293	12	the	the	DET
gs-3751	293	13	convergence	convergence	NOUN
gs-3751	293	14	of	of	ADP
gs-3751	293	15	cutting	cut	VERB
gs-3751	293	16	-	-	PUNCT
gs-3751	293	17	edge	edge	NOUN
gs-3751	293	18	technologies	technology	NOUN
gs-3751	293	19	,	,	PUNCT
gs-3751	293	20	personalized	personalized	ADJ
gs-3751	293	21	medicine	medicine	NOUN
gs-3751	293	22	,	,	PUNCT
gs-3751	293	23	and	and	CCONJ
gs-3751	293	24	global	global	ADJ
gs-3751	293	25	collaborations	collaboration	NOUN
gs-3751	293	26	heralds	herald	VERB
gs-3751	293	27	a	a	DET
gs-3751	293	28	transformative	transformative	ADJ
gs-3751	293	29	era	era	NOUN
gs-3751	293	30	in	in	ADP
gs-3751	293	31	neurology	neurology	NOUN
gs-3751	293	32	.	.	PUNCT
gs-3751	294	1	by	by	ADP
gs-3751	294	2	embracing	embrace	VERB
gs-3751	294	3	the	the	DET
gs-3751	294	4	complexity	complexity	NOUN
gs-3751	294	5	of	of	ADP
gs-3751	294	6	the	the	DET
gs-3751	294	7	gut	gut	NOUN
gs-3751	294	8	-	-	PUNCT
gs-3751	294	9	brain	brain	NOUN
gs-3751	294	10	axis	axis	NOUN
gs-3751	294	11	,	,	PUNCT
gs-3751	294	12	the	the	DET
gs-3751	294	13	scientific	scientific	ADJ
gs-3751	294	14	community	community	NOUN
gs-3751	294	15	can	can	AUX
gs-3751	294	16	advance	advance	VERB
gs-3751	294	17	beyond	beyond	ADP
gs-3751	294	18	symptomatic	symptomatic	ADJ
gs-3751	294	19	management	management	NOUN
gs-3751	294	20	toward	toward	ADP
gs-3751	294	21	prevention	prevention	NOUN
gs-3751	294	22	and	and	CCONJ
gs-3751	294	23	cure	cure	NOUN
gs-3751	294	24	,	,	PUNCT
gs-3751	294	25	offering	offer	VERB
gs-3751	294	26	hope	hope	NOUN
gs-3751	294	27	to	to	ADP
gs-3751	294	28	millions	million	NOUN
gs-3751	294	29	affected	affect	VERB
gs-3751	294	30	by	by	ADP
gs-3751	294	31	alzheimer	alzheimer	PROPN
gs-3751	294	32	’s	’s	PROPN
gs-3751	294	33	,	,	PUNCT
gs-3751	294	34	parkinson	parkinson	NOUN
gs-3751	294	35	’s	’s	PART
gs-3751	294	36	,	,	PUNCT
gs-3751	294	37	and	and	CCONJ
gs-3751	294	38	related	related	ADJ
gs-3751	294	39	disorders	disorder	NOUN
gs-3751	294	40	.	.	PUNCT
gs-3751	295	1	the	the	DET
gs-3751	295	2	gut	gut	NOUN
gs-3751	295	3	-	-	PUNCT
gs-3751	295	4	brain	brain	NOUN
gs-3751	295	5	axis	axis	NOUN
gs-3751	295	6	(	(	PUNCT
gs-3751	295	7	gba	gba	NOUN
gs-3751	295	8	)	)	PUNCT
gs-3751	295	9	continues	continue	VERB
gs-3751	295	10	to	to	PART
gs-3751	295	11	unravel	unravel	VERB
gs-3751	295	12	as	as	ADP
gs-3751	295	13	a	a	DET
gs-3751	295	14	labyrinth	labyrinth	NOUN
gs-3751	295	15	of	of	ADP
gs-3751	295	16	interactions	interaction	NOUN
gs-3751	295	17	where	where	SCONJ
gs-3751	295	18	microbial	microbial	ADJ
gs-3751	295	19	,	,	PUNCT
gs-3751	295	20	neural	neural	ADJ
gs-3751	295	21	,	,	PUNCT
gs-3751	295	22	and	and	CCONJ
gs-3751	295	23	immune	immune	ADJ
gs-3751	295	24	pathways	pathway	NOUN
gs-3751	295	25	intersect	intersect	ADJ
gs-3751	295	26	to	to	PART
gs-3751	295	27	shape	shape	VERB
gs-3751	295	28	neurodegenerative	neurodegenerative	ADJ
gs-3751	295	29	disease	disease	NOUN
gs-3751	295	30	trajectories	trajectory	NOUN
gs-3751	295	31	.	.	PUNCT
gs-3751	296	1	recent	recent	ADJ
gs-3751	296	2	advances	advance	NOUN
gs-3751	296	3	have	have	AUX
gs-3751	296	4	illuminated	illuminate	VERB
gs-3751	296	5	the	the	DET
gs-3751	296	6	role	role	NOUN
gs-3751	296	7	of	of	ADP
gs-3751	296	8	neuroimmune	neuroimmune	NOUN
gs-3751	296	9	crosstalk	crosstalk	NOUN
gs-3751	296	10	in	in	ADP
gs-3751	296	11	mediating	mediate	VERB
gs-3751	296	12	these	these	DET
gs-3751	296	13	interactions	interaction	NOUN
gs-3751	296	14	,	,	PUNCT
gs-3751	296	15	particularly	particularly	ADV
gs-3751	296	16	through	through	ADP
gs-3751	296	17	microglial	microglial	ADJ
gs-3751	296	18	priming	priming	NOUN
gs-3751	296	19	by	by	ADP
gs-3751	296	20	gut	gut	NOUN
gs-3751	296	21	-	-	PUNCT
gs-3751	296	22	derived	derive	VERB
gs-3751	296	23	metabolites	metabolite	NOUN
gs-3751	296	24	.	.	PUNCT
gs-3751	297	1	microglia	microglia	ADJ
gs-3751	297	2	,	,	PUNCT
gs-3751	297	3	the	the	DET
gs-3751	297	4	brain	brain	NOUN
gs-3751	297	5	’s	’s	PART
gs-3751	297	6	resident	resident	ADJ
gs-3751	297	7	immune	immune	ADJ
gs-3751	297	8	cells	cell	NOUN
gs-3751	297	9	,	,	PUNCT
gs-3751	297	10	exhibit	exhibit	VERB
gs-3751	297	11	a	a	DET
gs-3751	297	12	dual	dual	ADJ
gs-3751	297	13	role	role	NOUN
gs-3751	297	14	in	in	ADP
gs-3751	297	15	alzheimer	alzheimer	PROPN
gs-3751	297	16	’s	’s	PART
gs-3751	297	17	disease	disease	NOUN
gs-3751	297	18	(	(	PUNCT
gs-3751	297	19	ad	ad	NOUN
gs-3751	297	20	)	)	PUNCT
gs-3751	297	21	and	and	CCONJ
gs-3751	297	22	parkinson	parkinson	NOUN
gs-3751	297	23	’s	’s	PART
gs-3751	297	24	disease	disease	NOUN
gs-3751	297	25	(	(	PUNCT
gs-3751	297	26	pd	pd	NOUN
gs-3751	297	27	):	):	PUNCT
gs-3751	297	28	while	while	SCONJ
gs-3751	297	29	they	they	PRON
gs-3751	297	30	phagocytose	phagocytose	VERB
gs-3751	297	31	pathological	pathological	ADJ
gs-3751	297	32	proteins	protein	NOUN
gs-3751	297	33	like	like	ADP
gs-3751	297	34	aβ	aβ	NOUN
gs-3751	297	35	and	and	CCONJ
gs-3751	297	36	α	α	NOUN
gs-3751	297	37	-	-	PUNCT
gs-3751	297	38	synuclein	synuclein	ADJ
gs-3751	297	39	,	,	PUNCT
gs-3751	297	40	chronic	chronic	ADJ
gs-3751	297	41	activation	activation	NOUN
gs-3751	297	42	driven	drive	VERB
gs-3751	297	43	by	by	ADP
gs-3751	297	44	gut	gut	NOUN
gs-3751	297	45	dysbiosis	dysbiosis	NOUN
gs-3751	297	46	transforms	transform	VERB
gs-3751	297	47	them	they	PRON
gs-3751	297	48	into	into	ADP
gs-3751	297	49	agents	agent	NOUN
gs-3751	297	50	of	of	ADP
gs-3751	297	51	neuroinflammation	neuroinflammation	NOUN
gs-3751	297	52	.	.	PUNCT
gs-3751	298	1	for	for	ADP
gs-3751	298	2	instance	instance	NOUN
gs-3751	298	3	,	,	PUNCT
gs-3751	298	4	lipopolysaccharide	lipopolysaccharide	ADV
gs-3751	298	5	(	(	PUNCT
gs-3751	298	6	lps	lps	PROPN
gs-3751	298	7	)	)	PUNCT
gs-3751	298	8	from	from	ADP
gs-3751	298	9	gramnegative	gramnegative	ADJ
gs-3751	298	10	bacteria	bacteria	NOUN
gs-3751	298	11	such	such	ADJ
gs-3751	298	12	as	as	ADP
gs-3751	298	13	enterobacteriaceae	enterobacteriaceae	PROPN
gs-3751	298	14	binds	bind	VERB
gs-3751	298	15	to	to	ADP
gs-3751	298	16	toll	toll	NOUN
gs-3751	298	17	-	-	PUNCT
gs-3751	298	18	like	like	ADJ
gs-3751	298	19	receptor	receptor	NOUN
gs-3751	298	20	4	4	NUM
gs-3751	298	21	(	(	PUNCT
gs-3751	298	22	tlr4	tlr4	NOUN
gs-3751	298	23	)	)	PUNCT
gs-3751	298	24	on	on	ADP
gs-3751	298	25	microglia	microglia	NOUN
gs-3751	298	26	,	,	PUNCT
gs-3751	298	27	triggering	trigger	VERB
gs-3751	298	28	a	a	DET
gs-3751	298	29	cascade	cascade	NOUN
gs-3751	298	30	of	of	ADP
gs-3751	298	31	reactive	reactive	ADJ
gs-3751	298	32	oxygen	oxygen	NOUN
gs-3751	298	33	species	specie	NOUN
gs-3751	298	34	(	(	PUNCT
gs-3751	298	35	ros	ros	PROPN
gs-3751	298	36	)	)	PUNCT
gs-3751	298	37	and	and	CCONJ
gs-3751	298	38	interleukin-1β	interleukin-1β	NOUN
gs-3751	298	39	(	(	PUNCT
gs-3751	298	40	il-1β	il-1β	PROPN
gs-3751	298	41	)	)	PUNCT
gs-3751	298	42	release	release	NOUN
gs-3751	298	43	.	.	PUNCT
gs-3751	299	1	in	in	ADP
gs-3751	299	2	pd	pd	PROPN
gs-3751	299	3	models	model	NOUN
gs-3751	299	4	,	,	PUNCT
gs-3751	299	5	this	this	DET
gs-3751	299	6	process	process	NOUN
gs-3751	299	7	exacerbates	exacerbate	VERB
gs-3751	299	8	dopaminergic	dopaminergic	ADJ
gs-3751	299	9	neuron	neuron	NOUN
gs-3751	299	10	loss	loss	NOUN
gs-3751	299	11	in	in	ADP
gs-3751	299	12	the	the	DET
gs-3751	299	13	substantia	substantia	NOUN
gs-3751	299	14	nigra	nigra	NOUN
gs-3751	299	15	,	,	PUNCT
gs-3751	299	16	while	while	SCONJ
gs-3751	299	17	in	in	ADP
gs-3751	299	18	ad	ad	NOUN
gs-3751	299	19	,	,	PUNCT
gs-3751	299	20	it	it	PRON
gs-3751	299	21	amplifies	amplify	VERB
gs-3751	299	22	tau	tau	PROPN
gs-3751	299	23	hyperphosphorylation	hyperphosphorylation	NOUN
gs-3751	299	24	.	.	PUNCT
gs-3751	300	1	however	however	ADV
gs-3751	300	2	,	,	PUNCT
gs-3751	300	3	not	not	PART
gs-3751	300	4	all	all	DET
gs-3751	300	5	microbial	microbial	ADJ
gs-3751	300	6	signals	signal	NOUN
gs-3751	300	7	are	be	AUX
gs-3751	300	8	deleterious	deleterious	ADJ
gs-3751	300	9	.	.	PUNCT
gs-3751	301	1	bacteroides	bacteroide	VERB
gs-3751	301	2	fragilis	fragilis	PROPN
gs-3751	301	3	,	,	PUNCT
gs-3751	301	4	a	a	DET
gs-3751	301	5	commensal	commensal	NOUN
gs-3751	301	6	bacterium	bacterium	NOUN
gs-3751	301	7	,	,	PUNCT
gs-3751	301	8	produces	produce	VERB
gs-3751	301	9	polysaccharide	polysaccharide	ADV
gs-3751	301	10	a	a	DET
gs-3751	301	11	(	(	PUNCT
gs-3751	301	12	psa	psa	NOUN
gs-3751	301	13	)	)	PUNCT
gs-3751	301	14	,	,	PUNCT
gs-3751	301	15	which	which	PRON
gs-3751	301	16	induces	induce	VERB
gs-3751	301	17	regulatory	regulatory	ADJ
gs-3751	301	18	t	t	NOUN
gs-3751	301	19	cells	cell	NOUN
gs-3751	301	20	(	(	PUNCT
gs-3751	301	21	tregs	treg	NOUN
gs-3751	301	22	)	)	PUNCT
gs-3751	301	23	to	to	PART
gs-3751	301	24	secrete	secrete	VERB
gs-3751	301	25	anti	anti	ADJ
gs-3751	301	26	-	-	ADJ
gs-3751	301	27	inflammatory	inflammatory	ADJ
gs-3751	301	28	il-10	il-10	PRON
gs-3751	301	29	,	,	PUNCT
gs-3751	301	30	thereby	thereby	ADV
gs-3751	301	31	dampening	dampen	VERB
gs-3751	301	32	microglial	microglial	ADJ
gs-3751	301	33	hyperactivity	hyperactivity	NOUN
gs-3751	301	34	.	.	PUNCT
gs-3751	302	1	this	this	DET
gs-3751	302	2	dichotomy	dichotomy	NOUN
gs-3751	302	3	underscores	underscore	VERB
gs-3751	302	4	the	the	DET
gs-3751	302	5	microbiome	microbiome	NOUN
gs-3751	302	6	’s	’s	PART
gs-3751	302	7	capacity	capacity	NOUN
gs-3751	302	8	to	to	ADP
gs-3751	302	9	both	both	PRON
gs-3751	302	10	fuel	fuel	VERB
gs-3751	302	11	and	and	CCONJ
gs-3751	302	12	ameliorate	ameliorate	VERB
gs-3751	302	13	neurodegeneration	neurodegeneration	NOUN
gs-3751	302	14	,	,	PUNCT
gs-3751	302	15	depending	depend	VERB
gs-3751	302	16	on	on	ADP
gs-3751	302	17	ecological	ecological	ADJ
gs-3751	302	18	balance	balance	NOUN
gs-3751	302	19	.	.	PUNCT
gs-3751	303	1	emerging	emerge	VERB
gs-3751	303	2	research	research	NOUN
gs-3751	303	3	emphasizes	emphasize	VERB
gs-3751	303	4	the	the	DET
gs-3751	303	5	spatial	spatial	ADJ
gs-3751	303	6	organization	organization	NOUN
gs-3751	303	7	of	of	ADP
gs-3751	303	8	gut	gut	NOUN
gs-3751	303	9	microbiota	microbiota	NOUN
gs-3751	303	10	as	as	ADP
gs-3751	303	11	a	a	DET
gs-3751	303	12	critical	critical	ADJ
gs-3751	303	13	factor	factor	NOUN
gs-3751	303	14	in	in	ADP
gs-3751	303	15	gba	gba	PROPN
gs-3751	303	16	signaling	signaling	NOUN
gs-3751	303	17	.	.	PUNCT
gs-3751	304	1	mucosal	mucosal	NOUN
gs-3751	304	2	-	-	PUNCT
gs-3751	304	3	associated	associate	VERB
gs-3751	304	4	microbes	microbe	NOUN
gs-3751	304	5	,	,	PUNCT
gs-3751	304	6	which	which	PRON
gs-3751	304	7	reside	reside	VERB
gs-3751	304	8	in	in	ADP
gs-3751	304	9	close	close	ADJ
gs-3751	304	10	proximity	proximity	NOUN
gs-3751	304	11	to	to	ADP
gs-3751	304	12	the	the	DET
gs-3751	304	13	intestinal	intestinal	ADJ
gs-3751	304	14	epithelium	epithelium	NOUN
gs-3751	304	15	,	,	PUNCT
gs-3751	304	16	interact	interact	VERB
gs-3751	304	17	directly	directly	ADV
gs-3751	304	18	with	with	ADP
gs-3751	304	19	enteroendocrine	enteroendocrine	ADJ
gs-3751	304	20	cells	cell	NOUN
gs-3751	304	21	and	and	CCONJ
gs-3751	304	22	immune	immune	ADJ
gs-3751	304	23	receptors	receptor	NOUN
gs-3751	304	24	,	,	PUNCT
gs-3751	304	25	whereas	whereas	SCONJ
gs-3751	304	26	luminal	luminal	ADJ
gs-3751	304	27	microbes	microbe	NOUN
gs-3751	304	28	influence	influence	VERB
gs-3751	304	29	systemic	systemic	ADJ
gs-3751	304	30	metabolism	metabolism	NOUN
gs-3751	304	31	.	.	PUNCT
gs-3751	305	1	in	in	ADP
gs-3751	305	2	pd	pd	PROPN
gs-3751	305	3	,	,	PUNCT
gs-3751	305	4	akkermansia	akkermansia	PROPN
gs-3751	305	5	muciniphila	muciniphila	PROPN
gs-3751	305	6	,	,	PUNCT
gs-3751	305	7	a	a	DET
gs-3751	305	8	mucin	mucin	NOUN
gs-3751	305	9	-	-	PUNCT
gs-3751	305	10	degrading	degrade	VERB
gs-3751	305	11	bacterium	bacterium	NOUN
gs-3751	305	12	enriched	enrich	VERB
gs-3751	305	13	in	in	ADP
gs-3751	305	14	the	the	DET
gs-3751	305	15	mucosal	mucosal	NOUN
gs-3751	305	16	layer	layer	NOUN
gs-3751	305	17	,	,	PUNCT
gs-3751	305	18	enhances	enhance	VERB
gs-3751	305	19	gut	gut	NOUN
gs-3751	305	20	barrier	barrier	NOUN
gs-3751	305	21	integrity	integrity	NOUN
gs-3751	305	22	by	by	ADP
gs-3751	305	23	stimulating	stimulate	VERB
gs-3751	305	24	mucin	mucin	NOUN
gs-3751	305	25	production	production	NOUN
gs-3751	305	26	.	.	PUNCT
gs-3751	306	1	paradoxically	paradoxically	ADV
gs-3751	306	2	,	,	PUNCT
gs-3751	306	3	its	its	PRON
gs-3751	306	4	overgrowth	overgrowth	NOUN
gs-3751	306	5	in	in	ADP
gs-3751	306	6	ad	ad	NOUN
gs-3751	306	7	correlates	correlate	VERB
gs-3751	306	8	with	with	ADP
gs-3751	306	9	increased	increase	VERB
gs-3751	306	10	intestinal	intestinal	ADJ
gs-3751	306	11	permeability	permeability	NOUN
gs-3751	306	12	,	,	PUNCT
gs-3751	306	13	allowing	allow	VERB
gs-3751	306	14	neurotoxic	neurotoxic	ADJ
gs-3751	306	15	metabolites	metabolite	NOUN
gs-3751	306	16	like	like	ADP
gs-3751	306	17	β	β	NOUN
gs-3751	306	18	-	-	PUNCT
gs-3751	306	19	n	n	CCONJ
gs-3751	306	20	-	-	PUNCT
gs-3751	306	21	methylamino	methylamino	NOUN
gs-3751	306	22	-	-	PUNCT
gs-3751	306	23	l	l	NOUN
gs-3751	306	24	-	-	NOUN
gs-3751	306	25	alanine	alanine	NOUN
gs-3751	306	26	(	(	PUNCT
gs-3751	306	27	bmaa	bmaa	NOUN
gs-3751	306	28	)	)	PUNCT
gs-3751	306	29	to	to	PART
gs-3751	306	30	infiltrate	infiltrate	VERB
gs-3751	306	31	the	the	DET
gs-3751	306	32	brain	brain	NOUN
gs-3751	306	33	.	.	PUNCT
gs-3751	307	1	this	this	DET
gs-3751	307	2	spatial	spatial	ADJ
gs-3751	307	3	specificity	specificity	NOUN
gs-3751	307	4	suggests	suggest	VERB
gs-3751	307	5	that	that	SCONJ
gs-3751	307	6	microbial	microbial	ADJ
gs-3751	307	7	location	location	NOUN
gs-3751	307	8	,	,	PUNCT
gs-3751	307	9	not	not	PART
gs-3751	307	10	just	just	ADV
gs-3751	307	11	composition	composition	NOUN
gs-3751	307	12	,	,	PUNCT
gs-3751	307	13	determines	determine	VERB
gs-3751	307	14	their	their	PRON
gs-3751	307	15	functional	functional	ADJ
gs-3751	307	16	georgian	georgian	ADJ
gs-3751	307	17	scientists/ქართველი	scientists/ქართველი	NOUN
gs-3751	307	18	მეცნიერები	მეცნიერები	NOUN
gs-3751	307	19	ტ.	ტ.	VERB
gs-3751	307	20	7	7	NUM
gs-3751	307	21	n	n	DET
gs-3751	307	22	2	2	NUM
gs-3751	307	23	,	,	PUNCT
gs-3751	307	24	2025	2025	NUM
gs-3751	307	25	347	347	NUM
gs-3751	307	26	impact	impact	NOUN
gs-3751	307	27	.	.	PUNCT
gs-3751	308	1	advanced	advanced	ADJ
gs-3751	308	2	imaging	imaging	NOUN
gs-3751	308	3	techniques	technique	NOUN
gs-3751	308	4	,	,	PUNCT
gs-3751	308	5	such	such	ADJ
gs-3751	308	6	as	as	ADP
gs-3751	308	7	fluorescence	fluorescence	NOUN
gs-3751	308	8	in	in	ADP
gs-3751	308	9	situ	situ	ADJ
gs-3751	308	10	hybridization	hybridization	NOUN
gs-3751	308	11	(	(	PUNCT
gs-3751	308	12	fish	fish	NOUN
gs-3751	308	13	)	)	PUNCT
gs-3751	308	14	coupled	couple	VERB
gs-3751	308	15	with	with	ADP
gs-3751	308	16	confocal	confocal	ADJ
gs-3751	308	17	microscopy	microscopy	NOUN
gs-3751	308	18	,	,	PUNCT
gs-3751	308	19	now	now	ADV
gs-3751	308	20	enable	enable	VERB
gs-3751	308	21	researchers	researcher	NOUN
gs-3751	308	22	to	to	PART
gs-3751	308	23	map	map	VERB
gs-3751	308	24	microbial	microbial	ADJ
gs-3751	308	25	niches	niche	NOUN
gs-3751	308	26	in	in	ADP
gs-3751	308	27	the	the	DET
gs-3751	308	28	gut	gut	NOUN
gs-3751	308	29	,	,	PUNCT
gs-3751	308	30	revealing	reveal	VERB
gs-3751	308	31	how	how	SCONJ
gs-3751	308	32	perturbations	perturbation	NOUN
gs-3751	308	33	—	—	PUNCT
gs-3751	308	34	like	like	ADP
gs-3751	308	35	antibiotic	antibiotic	ADJ
gs-3751	308	36	use	use	NOUN
gs-3751	308	37	or	or	CCONJ
gs-3751	308	38	high	high	ADJ
gs-3751	308	39	-	-	PUNCT
gs-3751	308	40	fat	fat	NOUN
gs-3751	308	41	diets	diet	NOUN
gs-3751	308	42	—	—	PUNCT
gs-3751	308	43	disrupt	disrupt	VERB
gs-3751	308	44	these	these	DET
gs-3751	308	45	ecosystems	ecosystem	NOUN
gs-3751	308	46	and	and	CCONJ
gs-3751	308	47	propagate	propagate	ADJ
gs-3751	308	48	brain	brain	NOUN
gs-3751	308	49	pathology	pathology	NOUN
gs-3751	308	50	.	.	PUNCT
gs-3751	309	1	the	the	DET
gs-3751	309	2	pharmacomicrobiome	pharmacomicrobiome	NOUN
gs-3751	309	3	—	—	PUNCT
gs-3751	309	4	the	the	DET
gs-3751	309	5	interplay	interplay	NOUN
gs-3751	309	6	between	between	ADP
gs-3751	309	7	gut	gut	NOUN
gs-3751	309	8	microbes	microbe	NOUN
gs-3751	309	9	and	and	CCONJ
gs-3751	309	10	drugs	drug	NOUN
gs-3751	309	11	—	—	PUNCT
gs-3751	309	12	adds	add	VERB
gs-3751	309	13	another	another	DET
gs-3751	309	14	layer	layer	NOUN
gs-3751	309	15	of	of	ADP
gs-3751	309	16	complexity	complexity	NOUN
gs-3751	309	17	to	to	ADP
gs-3751	309	18	neurodegenerative	neurodegenerative	ADJ
gs-3751	309	19	disease	disease	NOUN
gs-3751	309	20	management	management	NOUN
gs-3751	309	21	.	.	PUNCT
gs-3751	310	1	levodopa	levodopa	NOUN
gs-3751	310	2	,	,	PUNCT
gs-3751	310	3	the	the	DET
gs-3751	310	4	gold	gold	NOUN
gs-3751	310	5	-	-	PUNCT
gs-3751	310	6	standard	standard	NOUN
gs-3751	310	7	therapy	therapy	NOUN
gs-3751	310	8	for	for	ADP
gs-3751	310	9	pd	pd	PROPN
gs-3751	310	10	,	,	PUNCT
gs-3751	310	11	is	be	AUX
gs-3751	310	12	metabolized	metabolize	VERB
gs-3751	310	13	by	by	ADP
gs-3751	310	14	bacterial	bacterial	ADJ
gs-3751	310	15	tyrosine	tyrosine	NOUN
gs-3751	310	16	decarboxylases	decarboxylase	NOUN
gs-3751	310	17	(	(	PUNCT
gs-3751	310	18	tdcs	tdc	NOUN
gs-3751	310	19	)	)	PUNCT
gs-3751	310	20	in	in	ADP
gs-3751	310	21	the	the	DET
gs-3751	310	22	small	small	ADJ
gs-3751	310	23	intestine	intestine	NOUN
gs-3751	310	24	,	,	PUNCT
gs-3751	310	25	reducing	reduce	VERB
gs-3751	310	26	its	its	PRON
gs-3751	310	27	bioavailability	bioavailability	NOUN
gs-3751	310	28	.	.	PUNCT
gs-3751	311	1	enterococcus	enterococcus	NOUN
gs-3751	311	2	faecalis	faecalis	PROPN
gs-3751	311	3	,	,	PUNCT
gs-3751	311	4	a	a	DET
gs-3751	311	5	common	common	ADJ
gs-3751	311	6	gut	gut	NOUN
gs-3751	311	7	resident	resident	NOUN
gs-3751	311	8	,	,	PUNCT
gs-3751	311	9	converts	convert	VERB
gs-3751	311	10	levodopa	levodopa	NOUN
gs-3751	311	11	to	to	PART
gs-3751	311	12	dopamine	dopamine	VERB
gs-3751	311	13	in	in	ADP
gs-3751	311	14	the	the	DET
gs-3751	311	15	gut	gut	NOUN
gs-3751	311	16	lumen	luman	NOUN
gs-3751	311	17	,	,	PUNCT
gs-3751	311	18	preventing	prevent	VERB
gs-3751	311	19	its	its	PRON
gs-3751	311	20	absorption	absorption	NOUN
gs-3751	311	21	and	and	CCONJ
gs-3751	311	22	necessitating	necessitate	VERB
gs-3751	311	23	higher	high	ADJ
gs-3751	311	24	doses	dose	NOUN
gs-3751	311	25	that	that	PRON
gs-3751	311	26	exacerbate	exacerbate	VERB
gs-3751	311	27	dyskinesias	dyskinesia	NOUN
gs-3751	311	28	.	.	PUNCT
gs-3751	312	1	conversely	conversely	ADV
gs-3751	312	2	,	,	PUNCT
gs-3751	312	3	the	the	DET
gs-3751	312	4	ad	ad	NOUN
gs-3751	312	5	drug	drug	NOUN
gs-3751	312	6	donepezil	donepezil	NOUN
gs-3751	312	7	,	,	PUNCT
gs-3751	312	8	an	an	DET
gs-3751	312	9	acetylcholinesterase	acetylcholinesterase	NOUN
gs-3751	312	10	inhibitor	inhibitor	NOUN
gs-3751	312	11	,	,	PUNCT
gs-3751	312	12	is	be	AUX
gs-3751	312	13	bioactivated	bioactivate	VERB
gs-3751	312	14	by	by	ADP
gs-3751	312	15	bacteroides	bacteroide	NOUN
gs-3751	312	16	thetaiotaomicron	thetaiotaomicron	NOUN
gs-3751	312	17	through	through	ADP
gs-3751	312	18	bacterial	bacterial	ADJ
gs-3751	312	19	hydrolysis	hydrolysis	NOUN
gs-3751	312	20	,	,	PUNCT
gs-3751	312	21	suggesting	suggest	VERB
gs-3751	312	22	that	that	SCONJ
gs-3751	312	23	microbiome	microbiome	ADJ
gs-3751	312	24	composition	composition	NOUN
gs-3751	312	25	could	could	AUX
gs-3751	312	26	influence	influence	VERB
gs-3751	312	27	drug	drug	NOUN
gs-3751	312	28	efficacy	efficacy	NOUN
gs-3751	312	29	.	.	PUNCT
gs-3751	313	1	this	this	DET
gs-3751	313	2	bidirectional	bidirectional	ADJ
gs-3751	313	3	relationship	relationship	NOUN
gs-3751	313	4	has	have	AUX
gs-3751	313	5	spurred	spur	VERB
gs-3751	313	6	the	the	DET
gs-3751	313	7	development	development	NOUN
gs-3751	313	8	of	of	ADP
gs-3751	313	9	pharmacomicrobiomics	pharmacomicrobiomic	NOUN
gs-3751	313	10	,	,	PUNCT
gs-3751	313	11	a	a	DET
gs-3751	313	12	field	field	NOUN
gs-3751	313	13	aimed	aim	VERB
gs-3751	313	14	at	at	ADP
gs-3751	313	15	personalizing	personalize	VERB
gs-3751	313	16	drug	drug	NOUN
gs-3751	313	17	regimens	regimen	NOUN
gs-3751	313	18	based	base	VERB
gs-3751	313	19	on	on	ADP
gs-3751	313	20	microbial	microbial	ADJ
gs-3751	313	21	biomarkers	biomarker	NOUN
gs-3751	313	22	.	.	PUNCT
gs-3751	314	1	for	for	ADP
gs-3751	314	2	example	example	NOUN
gs-3751	314	3	,	,	PUNCT
gs-3751	314	4	pd	pd	PROPN
gs-3751	314	5	patients	patient	NOUN
gs-3751	314	6	with	with	ADP
gs-3751	314	7	high	high	ADJ
gs-3751	314	8	enterococcus	enterococcus	NOUN
gs-3751	314	9	abundance	abundance	NOUN
gs-3751	314	10	might	might	AUX
gs-3751	314	11	benefit	benefit	VERB
gs-3751	314	12	from	from	ADP
gs-3751	314	13	co	co	NOUN
gs-3751	314	14	-	-	NOUN
gs-3751	314	15	administration	administration	NOUN
gs-3751	314	16	of	of	ADP
gs-3751	314	17	tdc	tdc	PROPN
gs-3751	314	18	inhibitors	inhibitor	NOUN
gs-3751	314	19	like	like	ADP
gs-3751	314	20	α	α	NOUN
gs-3751	314	21	-	-	NOUN
gs-3751	314	22	fluoromethyltyrosine	fluoromethyltyrosine	NOUN
gs-3751	314	23	(	(	PUNCT
gs-3751	314	24	afmt	afmt	NOUN
gs-3751	314	25	)	)	PUNCT
gs-3751	314	26	,	,	PUNCT
gs-3751	314	27	while	while	SCONJ
gs-3751	314	28	ad	ad	NOUN
gs-3751	314	29	patients	patient	NOUN
gs-3751	314	30	with	with	ADP
gs-3751	314	31	bacteroides	bacteroide	NOUN
gs-3751	314	32	-	-	PUNCT
gs-3751	314	33	dominant	dominant	ADJ
gs-3751	314	34	microbiomes	microbiomes	PROPN
gs-3751	314	35	could	could	AUX
gs-3751	314	36	require	require	VERB
gs-3751	314	37	lower	low	ADJ
gs-3751	314	38	donepezil	donepezil	NOUN
gs-3751	314	39	doses	dose	NOUN
gs-3751	314	40	.	.	PUNCT
gs-3751	315	1	such	such	ADJ
gs-3751	315	2	strategies	strategy	NOUN
gs-3751	315	3	promise	promise	VERB
gs-3751	315	4	to	to	PART
gs-3751	315	5	mitigate	mitigate	VERB
gs-3751	315	6	side	side	NOUN
gs-3751	315	7	effects	effect	NOUN
gs-3751	315	8	and	and	CCONJ
gs-3751	315	9	enhance	enhance	VERB
gs-3751	315	10	therapeutic	therapeutic	ADJ
gs-3751	315	11	precision	precision	NOUN
gs-3751	315	12	but	but	CCONJ
gs-3751	315	13	demand	demand	VERB
gs-3751	315	14	rigorous	rigorous	ADJ
gs-3751	315	15	validation	validation	NOUN
gs-3751	315	16	in	in	ADP
gs-3751	315	17	diverse	diverse	ADJ
gs-3751	315	18	cohorts	cohort	NOUN
gs-3751	315	19	.	.	PUNCT
gs-3751	316	1	a	a	DET
gs-3751	316	2	groundbreaking	groundbreake	VERB
gs-3751	316	3	frontier	frontier	NOUN
gs-3751	316	4	lies	lie	VERB
gs-3751	316	5	in	in	ADP
gs-3751	316	6	the	the	DET
gs-3751	316	7	role	role	NOUN
gs-3751	316	8	of	of	ADP
gs-3751	316	9	microbial	microbial	ADJ
gs-3751	316	10	extracellular	extracellular	ADJ
gs-3751	316	11	vesicles	vesicle	NOUN
gs-3751	316	12	(	(	PUNCT
gs-3751	316	13	evs	evs	NOUN
gs-3751	316	14	)	)	PUNCT
gs-3751	316	15	as	as	ADP
gs-3751	316	16	carriers	carrier	NOUN
gs-3751	316	17	of	of	ADP
gs-3751	316	18	gba	gba	NOUN
gs-3751	316	19	communication	communication	NOUN
gs-3751	316	20	.	.	PUNCT
gs-3751	317	1	gut	gut	NOUN
gs-3751	317	2	bacteria	bacteria	NOUN
gs-3751	317	3	secrete	secrete	NOUN
gs-3751	317	4	evs	evs	VERB
gs-3751	317	5	containing	contain	VERB
gs-3751	317	6	nucleic	nucleic	ADJ
gs-3751	317	7	acids	acid	NOUN
gs-3751	317	8	,	,	PUNCT
gs-3751	317	9	proteins	protein	NOUN
gs-3751	317	10	,	,	PUNCT
gs-3751	317	11	and	and	CCONJ
gs-3751	317	12	metabolites	metabolite	NOUN
gs-3751	317	13	that	that	PRON
gs-3751	317	14	traverse	traverse	VERB
gs-3751	317	15	the	the	DET
gs-3751	317	16	bloodstream	bloodstream	NOUN
gs-3751	317	17	and	and	CCONJ
gs-3751	317	18	cross	cross	VERB
gs-3751	317	19	the	the	DET
gs-3751	317	20	blood	blood	NOUN
gs-3751	317	21	-	-	PUNCT
gs-3751	317	22	brain	brain	NOUN
gs-3751	317	23	barrier	barrier	NOUN
gs-3751	317	24	(	(	PUNCT
gs-3751	317	25	bbb	bbb	NOUN
gs-3751	317	26	)	)	PUNCT
gs-3751	317	27	.	.	PUNCT
gs-3751	318	1	in	in	ADP
gs-3751	318	2	ad	ad	NOUN
gs-3751	318	3	,	,	PUNCT
gs-3751	318	4	lactobacillus	lactobacillus	NOUN
gs-3751	318	5	-	-	PUNCT
gs-3751	318	6	derived	derive	VERB
gs-3751	318	7	evs	evs	NOUN
gs-3751	318	8	deliver	deliver	VERB
gs-3751	318	9	mir-155	mir-155	NOUN
gs-3751	318	10	-	-	PUNCT
gs-3751	318	11	5p	5p	NUM
gs-3751	318	12	to	to	ADP
gs-3751	318	13	neurons	neuron	NOUN
gs-3751	318	14	,	,	PUNCT
gs-3751	318	15	downregulating	downregulating	NOUN
gs-3751	318	16	bace1	bace1	NOUN
gs-3751	318	17	expression	expression	NOUN
gs-3751	318	18	and	and	CCONJ
gs-3751	318	19	reducing	reduce	VERB
gs-3751	318	20	aβ	aβ	DET
gs-3751	318	21	production	production	NOUN
gs-3751	318	22	.	.	PUNCT
gs-3751	319	1	conversely	conversely	ADV
gs-3751	319	2	,	,	PUNCT
gs-3751	319	3	evs	evs	VERB
gs-3751	319	4	from	from	ADP
gs-3751	319	5	escherichia	escherichia	NOUN
gs-3751	319	6	coli	coli	NOUN
gs-3751	319	7	transport	transport	NOUN
gs-3751	319	8	curli	curli	NOUN
gs-3751	319	9	proteins	protein	NOUN
gs-3751	319	10	to	to	ADP
gs-3751	319	11	the	the	DET
gs-3751	319	12	brain	brain	NOUN
gs-3751	319	13	,	,	PUNCT
gs-3751	319	14	seeding	seed	VERB
gs-3751	319	15	α	α	NOUN
gs-3751	319	16	-	-	PUNCT
gs-3751	319	17	synuclein	synuclein	NOUN
gs-3751	319	18	aggregation	aggregation	NOUN
gs-3751	319	19	in	in	ADP
gs-3751	319	20	pd	pd	PROPN
gs-3751	319	21	.	.	PUNCT
gs-3751	320	1	these	these	DET
gs-3751	320	2	findings	finding	NOUN
gs-3751	320	3	position	position	VERB
gs-3751	320	4	bacterial	bacterial	ADJ
gs-3751	320	5	evs	evs	NOUN
gs-3751	320	6	as	as	ADP
gs-3751	320	7	both	both	CCONJ
gs-3751	320	8	therapeutic	therapeutic	ADJ
gs-3751	320	9	vehicles	vehicle	NOUN
gs-3751	320	10	and	and	CCONJ
gs-3751	320	11	pathogenic	pathogenic	ADJ
gs-3751	320	12	agents	agent	NOUN
gs-3751	320	13	.	.	PUNCT
gs-3751	321	1	synthetic	synthetic	ADJ
gs-3751	321	2	biology	biology	NOUN
gs-3751	321	3	approaches	approach	NOUN
gs-3751	321	4	are	be	AUX
gs-3751	321	5	now	now	ADV
gs-3751	321	6	engineering	engineer	VERB
gs-3751	321	7	evs	evs	NOUN
gs-3751	321	8	to	to	PART
gs-3751	321	9	deliver	deliver	VERB
gs-3751	321	10	neuroprotective	neuroprotective	ADJ
gs-3751	321	11	cargo	cargo	NOUN
gs-3751	321	12	—	—	PUNCT
gs-3751	321	13	for	for	ADP
gs-3751	321	14	example	example	NOUN
gs-3751	321	15	,	,	PUNCT
gs-3751	321	16	crispr	crispr	ADJ
gs-3751	321	17	-	-	PUNCT
gs-3751	321	18	cas9	cas9	NOUN
gs-3751	321	19	constructs	construct	NOUN
gs-3751	321	20	targeting	target	VERB
gs-3751	321	21	app	app	NOUN
gs-3751	321	22	gene	gene	NOUN
gs-3751	321	23	mutations	mutation	NOUN
gs-3751	321	24	in	in	ADP
gs-3751	321	25	ad	ad	NOUN
gs-3751	321	26	or	or	CCONJ
gs-3751	321	27	antioxidant	antioxidant	ADJ
gs-3751	321	28	enzymes	enzyme	NOUN
gs-3751	321	29	like	like	ADP
gs-3751	321	30	superoxide	superoxide	NOUN
gs-3751	321	31	dismutase	dismutase	NOUN
gs-3751	321	32	(	(	PUNCT
gs-3751	321	33	sod	sod	NOUN
gs-3751	321	34	)	)	PUNCT
gs-3751	321	35	to	to	PART
gs-3751	321	36	combat	combat	VERB
gs-3751	321	37	oxidative	oxidative	ADJ
gs-3751	321	38	stress	stress	NOUN
gs-3751	321	39	in	in	ADP
gs-3751	321	40	pd	pd	PROPN
gs-3751	321	41	.	.	PUNCT
gs-3751	322	1	however	however	ADV
gs-3751	322	2	,	,	PUNCT
gs-3751	322	3	challenges	challenge	NOUN
gs-3751	322	4	persist	persist	VERB
gs-3751	322	5	in	in	ADP
gs-3751	322	6	scaling	scale	VERB
gs-3751	322	7	ev	ev	ADP
gs-3751	322	8	production	production	NOUN
gs-3751	322	9	and	and	CCONJ
gs-3751	322	10	ensuring	ensure	VERB
gs-3751	322	11	targeted	targeted	ADJ
gs-3751	322	12	delivery	delivery	NOUN
gs-3751	322	13	,	,	PUNCT
gs-3751	322	14	necessitating	necessitate	VERB
gs-3751	322	15	innovations	innovation	NOUN
gs-3751	322	16	in	in	ADP
gs-3751	322	17	nanotechnology	nanotechnology	NOUN
gs-3751	322	18	and	and	CCONJ
gs-3751	322	19	bioengineering	bioengineering	NOUN
gs-3751	322	20	.	.	PUNCT
gs-3751	323	1	the	the	DET
gs-3751	323	2	temporal	temporal	ADJ
gs-3751	323	3	dimension	dimension	NOUN
gs-3751	323	4	of	of	ADP
gs-3751	323	5	microbiome	microbiome	ADJ
gs-3751	323	6	changes	change	NOUN
gs-3751	323	7	across	across	ADP
gs-3751	323	8	the	the	DET
gs-3751	323	9	lifespan	lifespan	NOUN
gs-3751	323	10	is	be	AUX
gs-3751	323	11	gaining	gain	VERB
gs-3751	323	12	recognition	recognition	NOUN
gs-3751	323	13	as	as	ADP
gs-3751	323	14	a	a	DET
gs-3751	323	15	determinant	determinant	NOUN
gs-3751	323	16	of	of	ADP
gs-3751	323	17	neurodegeneration	neurodegeneration	NOUN
gs-3751	323	18	risk	risk	NOUN
gs-3751	323	19	.	.	PUNCT
gs-3751	324	1	aging	aging	NOUN
gs-3751	324	2	is	be	AUX
gs-3751	324	3	associated	associate	VERB
gs-3751	324	4	with	with	ADP
gs-3751	324	5	a	a	DET
gs-3751	324	6	decline	decline	NOUN
gs-3751	324	7	in	in	ADP
gs-3751	324	8	microbial	microbial	ADJ
gs-3751	324	9	diversity	diversity	NOUN
gs-3751	324	10	,	,	PUNCT
gs-3751	324	11	termed	term	VERB
gs-3751	324	12	inflammaging	inflammage	VERB
gs-3751	324	13	,	,	PUNCT
gs-3751	324	14	characterized	characterize	VERB
gs-3751	324	15	by	by	ADP
gs-3751	324	16	reduced	reduce	VERB
gs-3751	324	17	scfa	scfa	ADJ
gs-3751	324	18	producers	producer	NOUN
gs-3751	324	19	(	(	PUNCT
gs-3751	324	20	faecalibacterium	faecalibacterium	NOUN
gs-3751	324	21	,	,	PUNCT
gs-3751	324	22	roseburia	roseburia	NOUN
gs-3751	324	23	)	)	PUNCT
gs-3751	324	24	and	and	CCONJ
gs-3751	324	25	expansion	expansion	NOUN
gs-3751	324	26	of	of	ADP
gs-3751	324	27	pathobionts	pathobiont	NOUN
gs-3751	324	28	(	(	PUNCT
gs-3751	324	29	proteobacteria	proteobacteria	NOUN
gs-3751	324	30	)	)	PUNCT
gs-3751	324	31	.	.	PUNCT
gs-3751	325	1	in	in	ADP
gs-3751	325	2	elderly	elderly	ADJ
gs-3751	325	3	populations	population	NOUN
gs-3751	325	4	,	,	PUNCT
gs-3751	325	5	this	this	DET
gs-3751	325	6	shift	shift	NOUN
gs-3751	325	7	correlates	correlate	VERB
gs-3751	325	8	with	with	ADP
gs-3751	325	9	increased	increase	VERB
gs-3751	325	10	bbb	bbb	NOUN
gs-3751	325	11	permeability	permeability	NOUN
gs-3751	325	12	and	and	CCONJ
gs-3751	325	13	microglial	microglial	ADJ
gs-3751	325	14	senescence	senescence	NOUN
gs-3751	325	15	,	,	PUNCT
gs-3751	325	16	creating	create	VERB
gs-3751	325	17	a	a	DET
gs-3751	325	18	permissive	permissive	ADJ
gs-3751	325	19	environment	environment	NOUN
gs-3751	325	20	for	for	ADP
gs-3751	325	21	proteinopathies	proteinopathie	NOUN
gs-3751	325	22	.	.	PUNCT
gs-3751	326	1	notably	notably	ADV
gs-3751	326	2	,	,	PUNCT
gs-3751	326	3	centenarians	centenarian	NOUN
gs-3751	326	4	with	with	ADP
gs-3751	326	5	preserved	preserve	VERB
gs-3751	326	6	cognitive	cognitive	ADJ
gs-3751	326	7	function	function	NOUN
gs-3751	326	8	exhibit	exhibit	VERB
gs-3751	326	9	microbiome	microbiome	ADJ
gs-3751	326	10	profiles	profile	NOUN
gs-3751	326	11	resembling	resemble	VERB
gs-3751	326	12	those	those	PRON
gs-3751	326	13	of	of	ADP
gs-3751	326	14	younger	young	ADJ
gs-3751	326	15	adults	adult	NOUN
gs-3751	326	16	,	,	PUNCT
gs-3751	326	17	dominated	dominate	VERB
gs-3751	326	18	by	by	ADP
gs-3751	326	19	christensenellaceae	christensenellaceae	PROPN
gs-3751	326	20	and	and	CCONJ
gs-3751	326	21	oscillospiraceae	oscillospiraceae	PROPN
gs-3751	326	22	,	,	PUNCT
gs-3751	326	23	suggesting	suggest	VERB
gs-3751	326	24	resilience	resilience	NOUN
gs-3751	326	25	against	against	ADP
gs-3751	326	26	age	age	NOUN
gs-3751	326	27	-	-	PUNCT
gs-3751	326	28	related	relate	VERB
gs-3751	326	29	dysbiosis	dysbiosis	NOUN
gs-3751	326	30	.	.	PUNCT
gs-3751	327	1	interventions	intervention	NOUN
gs-3751	327	2	aimed	aim	VERB
gs-3751	327	3	at	at	ADP
gs-3751	327	4	rejuvenating	rejuvenate	VERB
gs-3751	327	5	the	the	DET
gs-3751	327	6	aging	age	VERB
gs-3751	327	7	microbiome	microbiome	NOUN
gs-3751	327	8	—	—	PUNCT
gs-3751	327	9	such	such	ADJ
gs-3751	327	10	as	as	ADP
gs-3751	327	11	timed	time	VERB
gs-3751	327	12	feeding	feeding	NOUN
gs-3751	327	13	regimens	regimen	NOUN
gs-3751	327	14	to	to	PART
gs-3751	327	15	align	align	VERB
gs-3751	327	16	microbial	microbial	ADJ
gs-3751	327	17	rhythms	rhythm	NOUN
gs-3751	327	18	with	with	ADP
gs-3751	327	19	host	host	NOUN
gs-3751	327	20	circadian	circadian	ADJ
gs-3751	327	21	clocks	clock	NOUN
gs-3751	327	22	or	or	CCONJ
gs-3751	327	23	senolytic	senolytic	ADJ
gs-3751	327	24	therapies	therapy	NOUN
gs-3751	327	25	to	to	PART
gs-3751	327	26	eliminate	eliminate	VERB
gs-3751	327	27	senescent	senescent	ADJ
gs-3751	327	28	microbes	microbe	NOUN
gs-3751	327	29	—	—	PUNCT
gs-3751	327	30	are	be	AUX
gs-3751	327	31	now	now	ADV
gs-3751	327	32	under	under	ADP
gs-3751	327	33	investigation	investigation	NOUN
gs-3751	327	34	.	.	PUNCT
gs-3751	328	1	early	early	ADJ
gs-3751	328	2	results	result	NOUN
gs-3751	328	3	in	in	ADP
gs-3751	328	4	murine	murine	ADJ
gs-3751	328	5	models	model	NOUN
gs-3751	328	6	show	show	VERB
gs-3751	328	7	that	that	SCONJ
gs-3751	328	8	fecal	fecal	ADJ
gs-3751	328	9	transplants	transplant	NOUN
gs-3751	328	10	from	from	ADP
gs-3751	328	11	young	young	ADJ
gs-3751	328	12	donors	donor	NOUN
gs-3751	328	13	reverse	reverse	VERB
gs-3751	328	14	age	age	NOUN
gs-3751	328	15	-	-	PUNCT
gs-3751	328	16	related	relate	VERB
gs-3751	328	17	neuroinflammation	neuroinflammation	NOUN
gs-3751	328	18	and	and	CCONJ
gs-3751	328	19	improve	improve	VERB
gs-3751	328	20	spatial	spatial	ADJ
gs-3751	328	21	memory	memory	NOUN
gs-3751	328	22	,	,	PUNCT
gs-3751	328	23	though	though	SCONJ
gs-3751	328	24	ethical	ethical	ADJ
gs-3751	328	25	concerns	concern	NOUN
gs-3751	328	26	about	about	ADP
gs-3751	328	27	donor	donor	NOUN
gs-3751	328	28	sourcing	sourcing	NOUN
gs-3751	328	29	and	and	CCONJ
gs-3751	328	30	long	long	ADJ
gs-3751	328	31	-	-	PUNCT
gs-3751	328	32	term	term	NOUN
gs-3751	328	33	safety	safety	NOUN
gs-3751	328	34	remain	remain	VERB
gs-3751	328	35	unresolved	unresolved	ADJ
gs-3751	328	36	.	.	PUNCT
gs-3751	329	1	georgian	georgian	ADJ
gs-3751	329	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3751	329	3	მეცნიერები	მეცნიერები	NOUN
gs-3751	329	4	ტ.	ტ.	VERB
gs-3751	329	5	7	7	NUM
gs-3751	329	6	n	n	PRON
gs-3751	329	7	2	2	NUM
gs-3751	329	8	,	,	PUNCT
gs-3751	329	9	2025	2025	NUM
gs-3751	329	10	348	348	NUM
gs-3751	329	11	environmental	environmental	ADJ
gs-3751	329	12	toxins	toxin	NOUN
gs-3751	329	13	further	far	ADV
gs-3751	329	14	modulate	modulate	VERB
gs-3751	329	15	gba	gba	NOUN
gs-3751	329	16	dynamics	dynamic	NOUN
gs-3751	329	17	,	,	PUNCT
gs-3751	329	18	acting	act	VERB
gs-3751	329	19	as	as	ADP
gs-3751	329	20	silent	silent	ADJ
gs-3751	329	21	collaborators	collaborator	NOUN
gs-3751	329	22	in	in	ADP
gs-3751	329	23	neurodegeneration	neurodegeneration	NOUN
gs-3751	329	24	.	.	PUNCT
gs-3751	330	1	pesticides	pesticide	NOUN
gs-3751	330	2	like	like	ADP
gs-3751	330	3	paraquat	paraquat	NOUN
gs-3751	330	4	and	and	CCONJ
gs-3751	330	5	rotenone	rotenone	NOUN
gs-3751	330	6	,	,	PUNCT
gs-3751	330	7	implicated	implicate	VERB
gs-3751	330	8	in	in	ADP
gs-3751	330	9	pd	pd	PROPN
gs-3751	330	10	pathogenesis	pathogenesis	NOUN
gs-3751	330	11	,	,	PUNCT
gs-3751	330	12	disrupt	disrupt	VERB
gs-3751	330	13	gut	gut	NOUN
gs-3751	330	14	microbial	microbial	ADJ
gs-3751	330	15	communities	community	NOUN
gs-3751	330	16	by	by	ADP
gs-3751	330	17	selectively	selectively	ADV
gs-3751	330	18	inhibiting	inhibit	VERB
gs-3751	330	19	mitochondrial	mitochondrial	ADJ
gs-3751	330	20	complexes	complex	NOUN
gs-3751	330	21	in	in	ADP
gs-3751	330	22	lactobacillus	lactobacillus	NOUN
gs-3751	330	23	and	and	CCONJ
gs-3751	330	24	bifidobacterium	bifidobacterium	NOUN
gs-3751	330	25	,	,	PUNCT
gs-3751	330	26	genera	genera	NOUN
gs-3751	330	27	critical	critical	ADJ
gs-3751	330	28	for	for	ADP
gs-3751	330	29	dopamine	dopamine	NOUN
gs-3751	330	30	synthesis	synthesis	NOUN
gs-3751	330	31	and	and	CCONJ
gs-3751	330	32	gut	gut	NOUN
gs-3751	330	33	barrier	barrier	NOUN
gs-3751	330	34	maintenance	maintenance	NOUN
gs-3751	330	35	.	.	PUNCT
gs-3751	331	1	similarly	similarly	ADV
gs-3751	331	2	,	,	PUNCT
gs-3751	331	3	air	air	NOUN
gs-3751	331	4	pollution	pollution	NOUN
gs-3751	331	5	particles	particle	NOUN
gs-3751	331	6	(	(	PUNCT
gs-3751	331	7	pm2.5	pm2.5	ADV
gs-3751	331	8	)	)	PUNCT
gs-3751	331	9	alter	alter	VERB
gs-3751	331	10	the	the	DET
gs-3751	331	11	gut	gut	NOUN
gs-3751	331	12	virome	virome	NOUN
gs-3751	331	13	,	,	PUNCT
gs-3751	331	14	increasing	increase	VERB
gs-3751	331	15	bacteriophage	bacteriophage	NOUN
gs-3751	331	16	activity	activity	NOUN
gs-3751	331	17	that	that	PRON
gs-3751	331	18	lyses	lyse	VERB
gs-3751	331	19	beneficial	beneficial	ADJ
gs-3751	331	20	bacteria	bacteria	NOUN
gs-3751	331	21	,	,	PUNCT
gs-3751	331	22	as	as	SCONJ
gs-3751	331	23	shown	show	VERB
gs-3751	331	24	in	in	ADP
gs-3751	331	25	ad	ad	NOUN
gs-3751	331	26	mice	mouse	NOUN
gs-3751	331	27	exposed	expose	VERB
gs-3751	331	28	to	to	ADP
gs-3751	331	29	urban	urban	ADJ
gs-3751	331	30	pollutants	pollutant	NOUN
gs-3751	331	31	.	.	PUNCT
gs-3751	332	1	these	these	DET
gs-3751	332	2	toxins	toxin	NOUN
gs-3751	332	3	also	also	ADV
gs-3751	332	4	synergize	synergize	VERB
gs-3751	332	5	with	with	ADP
gs-3751	332	6	dysbiosis	dysbiosis	NOUN
gs-3751	332	7	to	to	PART
gs-3751	332	8	amplify	amplify	VERB
gs-3751	332	9	neuroinflammation	neuroinflammation	NOUN
gs-3751	332	10	;	;	PUNCT
gs-3751	332	11	for	for	ADP
gs-3751	332	12	example	example	NOUN
gs-3751	332	13	,	,	PUNCT
gs-3751	332	14	glyphosate	glyphosate	NOUN
gs-3751	332	15	exposure	exposure	NOUN
gs-3751	332	16	in	in	ADP
gs-3751	332	17	pd	pd	PROPN
gs-3751	332	18	patients	patient	NOUN
gs-3751	332	19	with	with	ADP
gs-3751	332	20	helicobacter	helicobacter	NOUN
gs-3751	332	21	pylori	pylori	NOUN
gs-3751	332	22	infection	infection	NOUN
gs-3751	332	23	doubles	double	VERB
gs-3751	332	24	the	the	DET
gs-3751	332	25	risk	risk	NOUN
gs-3751	332	26	of	of	ADP
gs-3751	332	27	motor	motor	NOUN
gs-3751	332	28	progression	progression	NOUN
gs-3751	332	29	compared	compare	VERB
gs-3751	332	30	to	to	ADP
gs-3751	332	31	either	either	DET
gs-3751	332	32	factor	factor	NOUN
gs-3751	332	33	alone	alone	ADV
gs-3751	332	34	.	.	PUNCT
gs-3751	333	1	this	this	DET
gs-3751	333	2	interplay	interplay	NOUN
gs-3751	333	3	highlights	highlight	VERB
gs-3751	333	4	the	the	DET
gs-3751	333	5	need	need	NOUN
gs-3751	333	6	for	for	ADP
gs-3751	333	7	environmental	environmental	ADJ
gs-3751	333	8	risk	risk	NOUN
gs-3751	333	9	assessments	assessment	NOUN
gs-3751	333	10	in	in	ADP
gs-3751	333	11	gba	gba	PROPN
gs-3751	333	12	research	research	NOUN
gs-3751	333	13	,	,	PUNCT
gs-3751	333	14	particularly	particularly	ADV
gs-3751	333	15	in	in	ADP
gs-3751	333	16	industrial	industrial	ADJ
gs-3751	333	17	regions	region	NOUN
gs-3751	333	18	where	where	SCONJ
gs-3751	333	19	toxin	toxin	NOUN
gs-3751	333	20	-	-	PUNCT
gs-3751	333	21	microbiome	microbiome	NOUN
gs-3751	333	22	interactions	interaction	NOUN
gs-3751	333	23	may	may	AUX
gs-3751	333	24	drive	drive	VERB
gs-3751	333	25	clustering	clustering	NOUN
gs-3751	333	26	of	of	ADP
gs-3751	333	27	neurodegenerative	neurodegenerative	ADJ
gs-3751	333	28	cases	case	NOUN
gs-3751	333	29	.	.	PUNCT
gs-3751	334	1	psychosocial	psychosocial	ADJ
gs-3751	334	2	stress	stress	NOUN
gs-3751	334	3	,	,	PUNCT
gs-3751	334	4	mediated	mediate	VERB
gs-3751	334	5	through	through	ADP
gs-3751	334	6	the	the	DET
gs-3751	334	7	gba	gba	NOUN
gs-3751	334	8	,	,	PUNCT
gs-3751	334	9	emerges	emerge	VERB
gs-3751	334	10	as	as	ADP
gs-3751	334	11	a	a	DET
gs-3751	334	12	modifiable	modifiable	ADJ
gs-3751	334	13	risk	risk	NOUN
gs-3751	334	14	factor	factor	NOUN
gs-3751	334	15	for	for	ADP
gs-3751	334	16	ad	ad	NOUN
gs-3751	334	17	and	and	CCONJ
gs-3751	334	18	pd	pd	PROPN
gs-3751	334	19	.	.	PROPN
gs-3751	334	20	chronic	chronic	PROPN
gs-3751	334	21	stress	stress	NOUN
gs-3751	334	22	elevates	elevate	VERB
gs-3751	334	23	cortisol	cortisol	ADJ
gs-3751	334	24	levels	level	NOUN
gs-3751	334	25	,	,	PUNCT
gs-3751	334	26	which	which	PRON
gs-3751	334	27	reshape	reshape	VERB
gs-3751	334	28	the	the	DET
gs-3751	334	29	gut	gut	NOUN
gs-3751	334	30	microbiome	microbiome	NOUN
gs-3751	334	31	by	by	ADP
gs-3751	334	32	enriching	enrich	VERB
gs-3751	334	33	stresstolerant	stresstolerant	ADJ
gs-3751	334	34	taxa	taxa	NOUN
gs-3751	334	35	(	(	PUNCT
gs-3751	334	36	bacteroides	bacteroide	NOUN
gs-3751	334	37	,	,	PUNCT
gs-3751	334	38	clostridium	clostridium	NOUN
gs-3751	334	39	)	)	PUNCT
gs-3751	334	40	and	and	CCONJ
gs-3751	334	41	depleting	deplete	VERB
gs-3751	334	42	gaba	gaba	NOUN
gs-3751	334	43	-	-	PUNCT
gs-3751	334	44	producing	produce	VERB
gs-3751	334	45	lactobacillus	lactobacillus	NOUN
gs-3751	334	46	.	.	PUNCT
gs-3751	335	1	gaba	gaba	PROPN
gs-3751	335	2	,	,	PUNCT
gs-3751	335	3	a	a	DET
gs-3751	335	4	key	key	ADJ
gs-3751	335	5	inhibitory	inhibitory	ADJ
gs-3751	335	6	neurotransmitter	neurotransmitter	NOUN
gs-3751	335	7	,	,	PUNCT
gs-3751	335	8	regulates	regulate	VERB
gs-3751	335	9	microglial	microglial	ADJ
gs-3751	335	10	activation	activation	NOUN
gs-3751	335	11	and	and	CCONJ
gs-3751	335	12	neuronal	neuronal	ADJ
gs-3751	335	13	excitability	excitability	NOUN
gs-3751	335	14	.	.	PUNCT
gs-3751	336	1	its	its	PRON
gs-3751	336	2	deficiency	deficiency	NOUN
gs-3751	336	3	in	in	ADP
gs-3751	336	4	stressed	stressed	ADJ
gs-3751	336	5	individuals	individual	NOUN
gs-3751	336	6	correlates	correlate	VERB
gs-3751	336	7	with	with	ADP
gs-3751	336	8	hippocampal	hippocampal	ADJ
gs-3751	336	9	atrophy	atrophy	NOUN
gs-3751	336	10	in	in	ADP
gs-3751	336	11	ad	ad	NOUN
gs-3751	336	12	and	and	CCONJ
gs-3751	336	13	nigrostriatal	nigrostriatal	ADJ
gs-3751	336	14	degeneration	degeneration	NOUN
gs-3751	336	15	in	in	ADP
gs-3751	336	16	pd	pd	PROPN
gs-3751	336	17	.	.	PROPN
gs-3751	336	18	mindfulness	mindfulness	NOUN
gs-3751	336	19	-	-	PUNCT
gs-3751	336	20	based	base	VERB
gs-3751	336	21	interventions	intervention	NOUN
gs-3751	336	22	,	,	PUNCT
gs-3751	336	23	such	such	ADJ
gs-3751	336	24	as	as	ADP
gs-3751	336	25	yoga	yoga	NOUN
gs-3751	336	26	and	and	CCONJ
gs-3751	336	27	meditation	meditation	NOUN
gs-3751	336	28	,	,	PUNCT
gs-3751	336	29	have	have	AUX
gs-3751	336	30	been	be	AUX
gs-3751	336	31	shown	show	VERB
gs-3751	336	32	to	to	PART
gs-3751	336	33	restore	restore	VERB
gs-3751	336	34	microbial	microbial	ADJ
gs-3751	336	35	diversity	diversity	NOUN
gs-3751	336	36	and	and	CCONJ
gs-3751	336	37	increase	increase	VERB
gs-3751	336	38	faecalibacterium	faecalibacterium	NOUN
gs-3751	336	39	abundance	abundance	NOUN
gs-3751	336	40	,	,	PUNCT
gs-3751	336	41	concomitant	concomitant	ADJ
gs-3751	336	42	with	with	ADP
gs-3751	336	43	reductions	reduction	NOUN
gs-3751	336	44	in	in	ADP
gs-3751	336	45	inflammatory	inflammatory	ADJ
gs-3751	336	46	cytokines	cytokine	NOUN
gs-3751	336	47	.	.	PUNCT
gs-3751	337	1	these	these	DET
gs-3751	337	2	practices	practice	NOUN
gs-3751	337	3	,	,	PUNCT
gs-3751	337	4	though	though	SCONJ
gs-3751	337	5	non	non	ADJ
gs-3751	337	6	-	-	ADJ
gs-3751	337	7	pharmacological	pharmacological	ADJ
gs-3751	337	8	,	,	PUNCT
gs-3751	337	9	could	could	AUX
gs-3751	337	10	complement	complement	VERB
gs-3751	337	11	existing	exist	VERB
gs-3751	337	12	therapies	therapy	NOUN
gs-3751	337	13	by	by	ADP
gs-3751	337	14	addressing	address	VERB
gs-3751	337	15	the	the	DET
gs-3751	337	16	bidirectional	bidirectional	ADJ
gs-3751	337	17	stress	stress	NOUN
gs-3751	337	18	-	-	PUNCT
gs-3751	337	19	gba	gba	NOUN
gs-3751	337	20	nexus	nexus	NOUN
gs-3751	337	21	,	,	PUNCT
gs-3751	337	22	offering	offer	VERB
gs-3751	337	23	a	a	DET
gs-3751	337	24	holistic	holistic	ADJ
gs-3751	337	25	approach	approach	NOUN
gs-3751	337	26	to	to	ADP
gs-3751	337	27	disease	disease	NOUN
gs-3751	337	28	management	management	NOUN
gs-3751	337	29	.	.	PUNCT
gs-3751	338	1	the	the	DET
gs-3751	338	2	evolutionary	evolutionary	ADJ
gs-3751	338	3	perspective	perspective	NOUN
gs-3751	338	4	of	of	ADP
gs-3751	338	5	the	the	DET
gs-3751	338	6	gba	gba	NOUN
gs-3751	338	7	provides	provide	VERB
gs-3751	338	8	intriguing	intriguing	ADJ
gs-3751	338	9	insights	insight	NOUN
gs-3751	338	10	into	into	ADP
gs-3751	338	11	its	its	PRON
gs-3751	338	12	role	role	NOUN
gs-3751	338	13	in	in	ADP
gs-3751	338	14	neurodegeneration	neurodegeneration	NOUN
gs-3751	338	15	.	.	PUNCT
gs-3751	339	1	humans	human	NOUN
gs-3751	339	2	have	have	AUX
gs-3751	339	3	co	co	VERB
gs-3751	339	4	-	-	VERB
gs-3751	339	5	evolved	evolve	VERB
gs-3751	339	6	with	with	ADP
gs-3751	339	7	commensal	commensal	NOUN
gs-3751	339	8	microbes	microbe	NOUN
gs-3751	339	9	for	for	ADP
gs-3751	339	10	millennia	millennia	NOUN
gs-3751	339	11	,	,	PUNCT
gs-3751	339	12	but	but	CCONJ
gs-3751	339	13	modern	modern	ADJ
gs-3751	339	14	lifestyle	lifestyle	NOUN
gs-3751	339	15	shifts	shift	NOUN
gs-3751	339	16	—	—	PUNCT
gs-3751	339	17	processed	process	VERB
gs-3751	339	18	diets	diet	NOUN
gs-3751	339	19	,	,	PUNCT
gs-3751	339	20	antibiotic	antibiotic	ADJ
gs-3751	339	21	overuse	overuse	NOUN
gs-3751	339	22	,	,	PUNCT
gs-3751	339	23	and	and	CCONJ
gs-3751	339	24	urbanization	urbanization	NOUN
gs-3751	339	25	—	—	PUNCT
gs-3751	339	26	have	have	AUX
gs-3751	339	27	disrupted	disrupt	VERB
gs-3751	339	28	this	this	DET
gs-3751	339	29	symbiosis	symbiosis	NOUN
gs-3751	339	30	.	.	PUNCT
gs-3751	340	1	ancestral	ancestral	ADJ
gs-3751	340	2	diets	diet	NOUN
gs-3751	340	3	rich	rich	ADJ
gs-3751	340	4	in	in	ADP
gs-3751	340	5	fiber	fiber	NOUN
gs-3751	340	6	and	and	CCONJ
gs-3751	340	7	fermented	ferment	VERB
gs-3751	340	8	foods	food	NOUN
gs-3751	340	9	supported	support	VERB
gs-3751	340	10	microbial	microbial	ADJ
gs-3751	340	11	taxa	taxa	NOUN
gs-3751	340	12	like	like	ADP
gs-3751	340	13	prevotella	prevotella	NOUN
gs-3751	340	14	,	,	PUNCT
gs-3751	340	15	which	which	PRON
gs-3751	340	16	degrade	degrade	VERB
gs-3751	340	17	complex	complex	ADJ
gs-3751	340	18	polysaccharides	polysaccharide	NOUN
gs-3751	340	19	into	into	ADP
gs-3751	340	20	anti	anti	ADJ
gs-3751	340	21	-	-	ADJ
gs-3751	340	22	inflammatory	inflammatory	ADJ
gs-3751	340	23	metabolites	metabolite	NOUN
gs-3751	340	24	.	.	PUNCT
gs-3751	341	1	in	in	ADP
gs-3751	341	2	contrast	contrast	NOUN
gs-3751	341	3	,	,	PUNCT
gs-3751	341	4	the	the	DET
gs-3751	341	5	western	western	ADJ
gs-3751	341	6	diet	diet	NOUN
gs-3751	341	7	favors	favor	VERB
gs-3751	341	8	bacteroides	bacteroide	NOUN
gs-3751	341	9	,	,	PUNCT
gs-3751	341	10	adept	adept	ADJ
gs-3751	341	11	at	at	ADP
gs-3751	341	12	metabolizing	metabolize	VERB
gs-3751	341	13	simple	simple	ADJ
gs-3751	341	14	sugars	sugar	NOUN
gs-3751	341	15	and	and	CCONJ
gs-3751	341	16	fats	fat	NOUN
gs-3751	341	17	linked	link	VERB
gs-3751	341	18	to	to	ADP
gs-3751	341	19	neuroinflammation	neuroinflammation	NOUN
gs-3751	341	20	.	.	PUNCT
gs-3751	342	1	evolutionary	evolutionary	ADJ
gs-3751	342	2	mismatch	mismatch	NOUN
gs-3751	342	3	theory	theory	NOUN
gs-3751	342	4	posits	posit	NOUN
gs-3751	342	5	that	that	SCONJ
gs-3751	342	6	the	the	DET
gs-3751	342	7	rapid	rapid	ADJ
gs-3751	342	8	divergence	divergence	NOUN
gs-3751	342	9	between	between	ADP
gs-3751	342	10	ancient	ancient	ADJ
gs-3751	342	11	and	and	CCONJ
gs-3751	342	12	modern	modern	ADJ
gs-3751	342	13	microbiomes	microbiomes	PROPN
gs-3751	342	14	underlies	underlie	VERB
gs-3751	342	15	the	the	DET
gs-3751	342	16	rising	rise	VERB
gs-3751	342	17	prevalence	prevalence	NOUN
gs-3751	342	18	of	of	ADP
gs-3751	342	19	neurodegenerative	neurodegenerative	ADJ
gs-3751	342	20	diseases	disease	NOUN
gs-3751	342	21	.	.	PUNCT
gs-3751	343	1	supporting	support	VERB
gs-3751	343	2	this	this	PRON
gs-3751	343	3	,	,	PUNCT
gs-3751	343	4	indigenous	indigenous	ADJ
gs-3751	343	5	populations	population	NOUN
gs-3751	343	6	with	with	ADP
gs-3751	343	7	traditional	traditional	ADJ
gs-3751	343	8	lifestyles	lifestyle	NOUN
gs-3751	343	9	,	,	PUNCT
gs-3751	343	10	such	such	ADJ
gs-3751	343	11	as	as	ADP
gs-3751	343	12	the	the	DET
gs-3751	343	13	hadza	hadza	PROPN
gs-3751	343	14	of	of	ADP
gs-3751	343	15	tanzania	tanzania	PROPN
gs-3751	343	16	,	,	PUNCT
gs-3751	343	17	exhibit	exhibit	VERB
gs-3751	343	18	gut	gut	NOUN
gs-3751	343	19	microbiomes	microbiome	NOUN
gs-3751	343	20	enriched	enrich	VERB
gs-3751	343	21	in	in	ADP
gs-3751	343	22	treponema	treponema	NOUN
gs-3751	343	23	,	,	PUNCT
gs-3751	343	24	a	a	DET
gs-3751	343	25	genus	genus	NOUN
gs-3751	343	26	associated	associate	VERB
gs-3751	343	27	with	with	ADP
gs-3751	343	28	scfa	scfa	ADJ
gs-3751	343	29	production	production	NOUN
gs-3751	343	30	and	and	CCONJ
gs-3751	343	31	virtually	virtually	ADV
gs-3751	343	32	absent	absent	ADJ
gs-3751	343	33	in	in	ADP
gs-3751	343	34	industrialized	industrialized	ADJ
gs-3751	343	35	societies	society	NOUN
gs-3751	343	36	.	.	PUNCT
gs-3751	344	1	recreating	recreate	VERB
gs-3751	344	2	ancestral	ancestral	ADJ
gs-3751	344	3	microbial	microbial	ADJ
gs-3751	344	4	ecosystems	ecosystem	NOUN
gs-3751	344	5	through	through	ADP
gs-3751	344	6	dietary	dietary	ADJ
gs-3751	344	7	or	or	CCONJ
gs-3751	344	8	probiotic	probiotic	ADJ
gs-3751	344	9	interventions	intervention	NOUN
gs-3751	344	10	may	may	AUX
gs-3751	344	11	offer	offer	VERB
gs-3751	344	12	protection	protection	NOUN
gs-3751	344	13	against	against	ADP
gs-3751	344	14	neurodegeneration	neurodegeneration	NOUN
gs-3751	344	15	,	,	PUNCT
gs-3751	344	16	though	though	SCONJ
gs-3751	344	17	feasibility	feasibility	NOUN
gs-3751	344	18	in	in	ADP
gs-3751	344	19	modern	modern	ADJ
gs-3751	344	20	settings	setting	NOUN
gs-3751	344	21	remains	remain	VERB
gs-3751	344	22	contentious	contentious	ADJ
gs-3751	344	23	.	.	PUNCT
gs-3751	345	1	technological	technological	ADJ
gs-3751	345	2	innovations	innovation	NOUN
gs-3751	345	3	are	be	AUX
gs-3751	345	4	poised	poise	VERB
gs-3751	345	5	to	to	PART
gs-3751	345	6	revolutionize	revolutionize	VERB
gs-3751	345	7	gba	gba	NOUN
gs-3751	345	8	therapeutics	therapeutic	NOUN
gs-3751	345	9	.	.	PUNCT
gs-3751	346	1	wearable	wearable	ADJ
gs-3751	346	2	devices	device	NOUN
gs-3751	346	3	equipped	equip	VERB
gs-3751	346	4	with	with	ADP
gs-3751	346	5	gut	gut	NOUN
gs-3751	346	6	sensors	sensor	NOUN
gs-3751	346	7	now	now	ADV
gs-3751	346	8	provide	provide	VERB
gs-3751	346	9	real	real	ADJ
gs-3751	346	10	-	-	PUNCT
gs-3751	346	11	time	time	NOUN
gs-3751	346	12	data	datum	NOUN
gs-3751	346	13	on	on	ADP
gs-3751	346	14	ph	ph	ADJ
gs-3751	346	15	,	,	PUNCT
gs-3751	346	16	temperature	temperature	NOUN
gs-3751	346	17	,	,	PUNCT
gs-3751	346	18	and	and	CCONJ
gs-3751	346	19	microbial	microbial	ADJ
gs-3751	346	20	metabolites	metabolite	NOUN
gs-3751	346	21	,	,	PUNCT
gs-3751	346	22	enabling	enable	VERB
gs-3751	346	23	dynamic	dynamic	ADJ
gs-3751	346	24	adjustments	adjustment	NOUN
gs-3751	346	25	to	to	ADP
gs-3751	346	26	diet	diet	NOUN
gs-3751	346	27	or	or	CCONJ
gs-3751	346	28	probiotics	probiotic	NOUN
gs-3751	346	29	.	.	PUNCT
gs-3751	347	1	in	in	ADP
gs-3751	347	2	a	a	DET
gs-3751	347	3	2024	2024	NUM
gs-3751	347	4	pilot	pilot	NOUN
gs-3751	347	5	study	study	NOUN
gs-3751	347	6	,	,	PUNCT
gs-3751	347	7	pd	pd	PROPN
gs-3751	347	8	patients	patient	NOUN
gs-3751	347	9	using	use	VERB
gs-3751	347	10	a	a	DET
gs-3751	347	11	smartwatch	smartwatch	NOUN
gs-3751	347	12	-	-	PUNCT
gs-3751	347	13	linked	link	VERB
gs-3751	347	14	probiotic	probiotic	ADJ
gs-3751	347	15	dispenser	dispenser	NOUN
gs-3751	347	16	experienced	experience	VERB
gs-3751	347	17	40	40	NUM
gs-3751	347	18	%	%	NOUN
gs-3751	347	19	fewer	few	ADJ
gs-3751	347	20	motor	motor	NOUN
gs-3751	347	21	fluctuations	fluctuation	NOUN
gs-3751	347	22	,	,	PUNCT
gs-3751	347	23	as	as	SCONJ
gs-3751	347	24	the	the	DET
gs-3751	347	25	device	device	NOUN
gs-3751	347	26	adjusted	adjust	VERB
gs-3751	347	27	bacillus	bacillus	NOUN
gs-3751	347	28	subtilis	subtili	NOUN
gs-3751	347	29	doses	dose	NOUN
gs-3751	347	30	based	base	VERB
gs-3751	347	31	on	on	ADP
gs-3751	347	32	real	real	ADJ
gs-3751	347	33	-	-	PUNCT
gs-3751	347	34	time	time	NOUN
gs-3751	347	35	α	α	NUM
gs-3751	347	36	-	-	PUNCT
gs-3751	347	37	synuclein	synuclein	NOUN
gs-3751	347	38	levels	level	NOUN
gs-3751	347	39	detected	detect	VERB
gs-3751	347	40	in	in	ADP
gs-3751	347	41	sweat	sweat	NOUN
gs-3751	347	42	.	.	PUNCT
gs-3751	348	1	artificial	artificial	ADJ
gs-3751	348	2	intelligence	intelligence	NOUN
gs-3751	348	3	(	(	PUNCT
gs-3751	348	4	ai	ai	NOUN
gs-3751	348	5	)	)	PUNCT
gs-3751	348	6	platforms	platform	NOUN
gs-3751	348	7	,	,	PUNCT
gs-3751	348	8	trained	train	VERB
gs-3751	348	9	on	on	ADP
gs-3751	348	10	multi	multi	ADJ
gs-3751	348	11	-	-	ADJ
gs-3751	348	12	omic	omic	ADJ
gs-3751	348	13	datasets	dataset	NOUN
gs-3751	348	14	,	,	PUNCT
gs-3751	348	15	predict	predict	VERB
gs-3751	348	16	individual	individual	ADJ
gs-3751	348	17	responses	response	NOUN
gs-3751	348	18	to	to	PART
gs-3751	348	19	fmt	fmt	VERB
gs-3751	348	20	or	or	CCONJ
gs-3751	348	21	probiotics	probiotic	NOUN
gs-3751	348	22	with	with	ADP
gs-3751	348	23	89	89	NUM
gs-3751	348	24	%	%	NOUN
gs-3751	348	25	accuracy	accuracy	NOUN
gs-3751	348	26	,	,	PUNCT
gs-3751	348	27	as	as	SCONJ
gs-3751	348	28	demonstrated	demonstrate	VERB
gs-3751	348	29	in	in	ADP
gs-3751	348	30	the	the	DET
gs-3751	348	31	ai	ai	ADJ
gs-3751	348	32	-	-	PUNCT
gs-3751	348	33	microbiome	microbiome	ADJ
gs-3751	348	34	nexus	nexus	NOUN
gs-3751	348	35	trial	trial	NOUN
gs-3751	348	36	.	.	PUNCT
gs-3751	349	1	meanwhile	meanwhile	ADV
gs-3751	349	2	,	,	PUNCT
gs-3751	349	3	crispr	crispr	NOUN
gs-3751	349	4	-	-	PUNCT
gs-3751	349	5	based	base	VERB
gs-3751	349	6	microbial	microbial	ADJ
gs-3751	349	7	editors	editor	NOUN
gs-3751	349	8	,	,	PUNCT
gs-3751	349	9	such	such	ADJ
gs-3751	349	10	as	as	ADP
gs-3751	349	11	engineered	engineer	VERB
gs-3751	349	12	lactobacillus	lactobacillus	NOUN
gs-3751	349	13	delivering	deliver	VERB
gs-3751	349	14	aβ	aβ	NOUN
gs-3751	349	15	-	-	PUNCT
gs-3751	349	16	neutralizing	neutralize	VERB
gs-3751	349	17	nanobodies	nanobodie	NOUN
gs-3751	349	18	,	,	PUNCT
gs-3751	349	19	are	be	AUX
gs-3751	349	20	entering	enter	VERB
gs-3751	349	21	phase	phase	NOUN
gs-3751	349	22	i	i	PRON
gs-3751	349	23	trials	trial	NOUN
gs-3751	349	24	,	,	PUNCT
gs-3751	349	25	heralding	herald	VERB
gs-3751	349	26	an	an	DET
gs-3751	349	27	era	era	NOUN
gs-3751	349	28	of	of	ADP
gs-3751	349	29	living	living	NOUN
gs-3751	349	30	biotherapeutics	biotherapeutic	NOUN
gs-3751	349	31	.	.	PUNCT
gs-3751	350	1	georgian	georgian	ADJ
gs-3751	350	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3751	350	3	მეცნიერები	მეცნიერები	NOUN
gs-3751	350	4	ტ.	ტ.	VERB
gs-3751	350	5	7	7	NUM
gs-3751	350	6	n	n	DET
gs-3751	350	7	2	2	NUM
gs-3751	350	8	,	,	PUNCT
gs-3751	350	9	2025	2025	NUM
gs-3751	350	10	349	349	NUM
gs-3751	350	11	the	the	DET
gs-3751	350	12	advancements	advancement	NOUN
gs-3751	350	13	must	must	AUX
gs-3751	350	14	navigate	navigate	VERB
gs-3751	350	15	ethical	ethical	ADJ
gs-3751	350	16	and	and	CCONJ
gs-3751	350	17	societal	societal	ADJ
gs-3751	350	18	challenges	challenge	NOUN
gs-3751	350	19	.	.	PUNCT
gs-3751	351	1	the	the	DET
gs-3751	351	2	privatization	privatization	NOUN
gs-3751	351	3	of	of	ADP
gs-3751	351	4	microbiome	microbiome	ADJ
gs-3751	351	5	data	datum	NOUN
gs-3751	351	6	by	by	ADP
gs-3751	351	7	corporations	corporation	NOUN
gs-3751	351	8	raises	raise	VERB
gs-3751	351	9	concerns	concern	NOUN
gs-3751	351	10	about	about	ADP
gs-3751	351	11	exploitation	exploitation	NOUN
gs-3751	351	12	,	,	PUNCT
gs-3751	351	13	as	as	SCONJ
gs-3751	351	14	patents	patent	NOUN
gs-3751	351	15	on	on	ADP
gs-3751	351	16	microbial	microbial	ADJ
gs-3751	351	17	strains	strain	NOUN
gs-3751	351	18	or	or	CCONJ
gs-3751	351	19	genetic	genetic	ADJ
gs-3751	351	20	edits	edit	NOUN
gs-3751	351	21	could	could	AUX
gs-3751	351	22	limit	limit	VERB
gs-3751	351	23	access	access	NOUN
gs-3751	351	24	for	for	ADP
gs-3751	351	25	low	low	ADJ
gs-3751	351	26	-	-	PUNCT
gs-3751	351	27	income	income	NOUN
gs-3751	351	28	populations	population	NOUN
gs-3751	351	29	.	.	PUNCT
gs-3751	352	1	moreover	moreover	ADV
gs-3751	352	2	,	,	PUNCT
gs-3751	352	3	the	the	DET
gs-3751	352	4	psychological	psychological	ADJ
gs-3751	352	5	impact	impact	NOUN
gs-3751	352	6	of	of	ADP
gs-3751	352	7	microbiome	microbiome	ADJ
gs-3751	352	8	testing	testing	NOUN
gs-3751	352	9	—	—	PUNCT
gs-3751	352	10	such	such	ADJ
gs-3751	352	11	as	as	ADP
gs-3751	352	12	anxiety	anxiety	NOUN
gs-3751	352	13	over	over	ADP
gs-3751	352	14	“	"	PUNCT
gs-3751	352	15	dysbiosis	dysbiosis	NOUN
gs-3751	352	16	”	"	PUNCT
gs-3751	352	17	diagnoses	diagnosis	NOUN
gs-3751	352	18	—	—	PUNCT
gs-3751	352	19	calls	call	VERB
gs-3751	352	20	for	for	ADP
gs-3751	352	21	ethical	ethical	ADJ
gs-3751	352	22	guidelines	guideline	NOUN
gs-3751	352	23	on	on	ADP
gs-3751	352	24	data	datum	NOUN
gs-3751	352	25	communication	communication	NOUN
gs-3751	352	26	.	.	PUNCT
gs-3751	353	1	global	global	ADJ
gs-3751	353	2	equity	equity	NOUN
gs-3751	353	3	must	must	AUX
gs-3751	353	4	be	be	AUX
gs-3751	353	5	prioritized	prioritize	VERB
gs-3751	353	6	;	;	PUNCT
gs-3751	353	7	while	while	SCONJ
gs-3751	353	8	high	high	ADJ
gs-3751	353	9	-	-	PUNCT
gs-3751	353	10	income	income	NOUN
gs-3751	353	11	countries	country	NOUN
gs-3751	353	12	pioneer	pioneer	PROPN
gs-3751	353	13	costly	costly	ADJ
gs-3751	353	14	fmt	fmt	NOUN
gs-3751	353	15	and	and	CCONJ
gs-3751	353	16	crispr	crispr	ADJ
gs-3751	353	17	therapies	therapy	NOUN
gs-3751	353	18	,	,	PUNCT
gs-3751	353	19	low	low	ADJ
gs-3751	353	20	-	-	PUNCT
gs-3751	353	21	resource	resource	NOUN
gs-3751	353	22	regions	region	NOUN
gs-3751	353	23	could	could	AUX
gs-3751	353	24	benefit	benefit	VERB
gs-3751	353	25	from	from	ADP
gs-3751	353	26	affordable	affordable	ADJ
gs-3751	353	27	interventions	intervention	NOUN
gs-3751	353	28	like	like	ADP
gs-3751	353	29	locally	locally	ADV
gs-3751	353	30	sourced	source	VERB
gs-3751	353	31	synbiotics	synbiotic	NOUN
gs-3751	353	32	or	or	CCONJ
gs-3751	353	33	phage	phage	NOUN
gs-3751	353	34	cocktails	cocktail	NOUN
gs-3751	353	35	targeting	target	VERB
gs-3751	353	36	endemic	endemic	ADJ
gs-3751	353	37	pathogens	pathogen	NOUN
gs-3751	353	38	.	.	PUNCT
gs-3751	354	1	in	in	ADP
gs-3751	354	2	synthesizing	synthesize	VERB
gs-3751	354	3	these	these	DET
gs-3751	354	4	threads	thread	NOUN
gs-3751	354	5	,	,	PUNCT
gs-3751	354	6	the	the	DET
gs-3751	354	7	gba	gba	NOUN
gs-3751	354	8	emerges	emerge	VERB
gs-3751	354	9	not	not	PART
gs-3751	354	10	as	as	ADP
gs-3751	354	11	a	a	DET
gs-3751	354	12	linear	linear	ADJ
gs-3751	354	13	pathway	pathway	NOUN
gs-3751	354	14	but	but	CCONJ
gs-3751	354	15	as	as	ADP
gs-3751	354	16	a	a	DET
gs-3751	354	17	dynamic	dynamic	ADJ
gs-3751	354	18	,	,	PUNCT
gs-3751	354	19	multidimensional	multidimensional	ADJ
gs-3751	354	20	network	network	NOUN
gs-3751	354	21	where	where	SCONJ
gs-3751	354	22	microbial	microbial	ADJ
gs-3751	354	23	,	,	PUNCT
gs-3751	354	24	environmental	environmental	ADJ
gs-3751	354	25	,	,	PUNCT
gs-3751	354	26	and	and	CCONJ
gs-3751	354	27	host	host	NOUN
gs-3751	354	28	factors	factor	NOUN
gs-3751	354	29	converge	converge	VERB
gs-3751	354	30	.	.	PUNCT
gs-3751	355	1	its	its	PRON
gs-3751	355	2	complexity	complexity	NOUN
gs-3751	355	3	demands	demand	VERB
gs-3751	355	4	a	a	DET
gs-3751	355	5	shift	shift	NOUN
gs-3751	355	6	from	from	ADP
gs-3751	355	7	reductionist	reductionist	ADJ
gs-3751	355	8	models	model	NOUN
gs-3751	355	9	to	to	ADP
gs-3751	355	10	systems	system	NOUN
gs-3751	355	11	biology	biology	NOUN
gs-3751	355	12	approaches	approach	NOUN
gs-3751	355	13	,	,	PUNCT
gs-3751	355	14	integrating	integrate	VERB
gs-3751	355	15	data	datum	NOUN
gs-3751	355	16	from	from	ADP
gs-3751	355	17	genomics	genomic	NOUN
gs-3751	355	18	,	,	PUNCT
gs-3751	355	19	metabolomics	metabolomic	NOUN
gs-3751	355	20	,	,	PUNCT
gs-3751	355	21	and	and	CCONJ
gs-3751	355	22	digital	digital	ADJ
gs-3751	355	23	health	health	NOUN
gs-3751	355	24	.	.	PUNCT
gs-3751	356	1	while	while	SCONJ
gs-3751	356	2	challenges	challenge	NOUN
gs-3751	356	3	—	—	PUNCT
gs-3751	356	4	from	from	ADP
gs-3751	356	5	mechanistic	mechanistic	ADJ
gs-3751	356	6	ambiguity	ambiguity	NOUN
gs-3751	356	7	to	to	ADP
gs-3751	356	8	ethical	ethical	ADJ
gs-3751	356	9	dilemmas	dilemma	NOUN
gs-3751	356	10	—	—	PUNCT
gs-3751	356	11	abound	abound	NOUN
gs-3751	356	12	,	,	PUNCT
gs-3751	356	13	the	the	DET
gs-3751	356	14	gba	gba	PROPN
gs-3751	356	15	paradigm	paradigm	NOUN
gs-3751	356	16	offers	offer	VERB
gs-3751	356	17	a	a	DET
gs-3751	356	18	transformative	transformative	ADJ
gs-3751	356	19	lens	lens	NOUN
gs-3751	356	20	through	through	ADP
gs-3751	356	21	which	which	PRON
gs-3751	356	22	to	to	PART
gs-3751	356	23	reimagine	reimagine	VERB
gs-3751	356	24	neurodegeneration	neurodegeneration	NOUN
gs-3751	356	25	.	.	PUNCT
gs-3751	357	1	by	by	ADP
gs-3751	357	2	bridging	bridge	VERB
gs-3751	357	3	disciplines	discipline	NOUN
gs-3751	357	4	and	and	CCONJ
gs-3751	357	5	embracing	embrace	VERB
gs-3751	357	6	innovation	innovation	NOUN
gs-3751	357	7	,	,	PUNCT
gs-3751	357	8	we	we	PRON
gs-3751	357	9	inch	inch	VERB
gs-3751	357	10	closer	close	ADV
gs-3751	357	11	to	to	ADP
gs-3751	357	12	a	a	DET
gs-3751	357	13	future	future	NOUN
gs-3751	357	14	where	where	SCONJ
gs-3751	357	15	alzheimer	alzheimer	PROPN
gs-3751	357	16	’s	’s	PART
gs-3751	357	17	and	and	CCONJ
gs-3751	357	18	parkinson	parkinson	NOUN
gs-3751	357	19	’s	’s	PART
gs-3751	357	20	are	be	AUX
gs-3751	357	21	not	not	PART
gs-3751	357	22	merely	merely	ADV
gs-3751	357	23	managed	manage	VERB
gs-3751	357	24	but	but	CCONJ
gs-3751	357	25	prevented	prevent	VERB
gs-3751	357	26	,	,	PUNCT
gs-3751	357	27	their	their	PRON
gs-3751	357	28	roots	root	NOUN
gs-3751	357	29	in	in	ADP
gs-3751	357	30	the	the	DET
gs-3751	357	31	gut	gut	NOUN
gs-3751	357	32	severed	sever	VERB
gs-3751	357	33	before	before	SCONJ
gs-3751	357	34	they	they	PRON
gs-3751	357	35	reach	reach	VERB
gs-3751	357	36	the	the	DET
gs-3751	357	37	brain	brain	NOUN
gs-3751	357	38	.	.	PUNCT
gs-3751	358	1			VERB
gs-3751	358	2	challenges	challenge	NOUN
gs-3751	358	3	and	and	CCONJ
gs-3751	358	4	future	future	ADJ
gs-3751	358	5	directions	direction	NOUN
gs-3751	358	6	:	:	PUNCT
gs-3751	358	7	future	future	ADJ
gs-3751	358	8	studies	study	NOUN
gs-3751	358	9	should	should	AUX
gs-3751	358	10	try	try	VERB
gs-3751	358	11	to	to	PART
gs-3751	358	12	standardize	standardize	VERB
gs-3751	358	13	the	the	DET
gs-3751	358	14	microbiome	microbiome	NOUN
gs-3751	358	15	intervention	intervention	NOUN
gs-3751	358	16	protocols	protocol	NOUN
gs-3751	358	17	to	to	PART
gs-3751	358	18	ensure	ensure	VERB
gs-3751	358	19	consistency	consistency	NOUN
gs-3751	358	20	.	.	PUNCT
gs-3751	359	1	use	use	NOUN
gs-3751	359	2	of	of	ADP
gs-3751	359	3	personalized	personalized	ADJ
gs-3751	359	4	approaches	approach	NOUN
gs-3751	359	5	based	base	VERB
gs-3751	359	6	on	on	ADP
gs-3751	359	7	the	the	DET
gs-3751	359	8	individual	individual	ADJ
gs-3751	359	9	microbiome	microbiome	NOUN
gs-3751	359	10	profile	profile	NOUN
gs-3751	359	11	and	and	CCONJ
gs-3751	359	12	a	a	DET
gs-3751	359	13	person	person	NOUN
gs-3751	359	14	’s	’s	PART
gs-3751	359	15	genetic	genetic	ADJ
gs-3751	359	16	predisposition	predisposition	NOUN
gs-3751	359	17	can	can	AUX
gs-3751	359	18	enhance	enhance	VERB
gs-3751	359	19	the	the	DET
gs-3751	359	20	effects	effect	NOUN
gs-3751	359	21	of	of	ADP
gs-3751	359	22	the	the	DET
gs-3751	359	23	treatment	treatment	NOUN
gs-3751	359	24	.	.	PUNCT
gs-3751	360	1	longitudinal	longitudinal	ADJ
gs-3751	360	2	studies	study	NOUN
gs-3751	360	3	are	be	AUX
gs-3751	360	4	essential	essential	ADJ
gs-3751	360	5	to	to	ADP
gs-3751	360	6	establishing	establish	VERB
gs-3751	360	7	causality	causality	NOUN
gs-3751	360	8	and	and	CCONJ
gs-3751	360	9	long	long	ADJ
gs-3751	360	10	-	-	PUNCT
gs-3751	360	11	term	term	NOUN
gs-3751	360	12	benefits	benefit	NOUN
gs-3751	360	13	.	.	PUNCT
gs-3751	361	1	despite	despite	SCONJ
gs-3751	361	2	these	these	DET
gs-3751	361	3	advances	advance	NOUN
gs-3751	361	4	,	,	PUNCT
gs-3751	361	5	translating	translate	VERB
gs-3751	361	6	preclinical	preclinical	ADJ
gs-3751	361	7	findings	finding	NOUN
gs-3751	361	8	to	to	ADP
gs-3751	361	9	humans	human	NOUN
gs-3751	361	10	remains	remain	VERB
gs-3751	361	11	fraught	fraught	ADJ
gs-3751	361	12	with	with	ADP
gs-3751	361	13	obstacles	obstacle	NOUN
gs-3751	361	14	.	.	PUNCT
gs-3751	362	1	the	the	DET
gs-3751	362	2	gut	gut	NOUN
gs-3751	362	3	microbiome	microbiome	PROPN
gs-3751	362	4	’s	’s	PART
gs-3751	362	5	heterogeneity	heterogeneity	NOUN
gs-3751	362	6	,	,	PUNCT
gs-3751	362	7	influenced	influence	VERB
gs-3751	362	8	by	by	ADP
gs-3751	362	9	diet	diet	NOUN
gs-3751	362	10	,	,	PUNCT
gs-3751	362	11	geography	geography	NOUN
gs-3751	362	12	,	,	PUNCT
gs-3751	362	13	and	and	CCONJ
gs-3751	362	14	genetics	genetic	NOUN
gs-3751	362	15	,	,	PUNCT
gs-3751	362	16	complicates	complicate	VERB
gs-3751	362	17	standardization	standardization	NOUN
gs-3751	362	18	.	.	PUNCT
gs-3751	363	1	for	for	ADP
gs-3751	363	2	instance	instance	NOUN
gs-3751	363	3	,	,	PUNCT
gs-3751	363	4	high	high	ADJ
gs-3751	363	5	-	-	PUNCT
gs-3751	363	6	fiber	fiber	NOUN
gs-3751	363	7	diets	diet	NOUN
gs-3751	363	8	boost	boost	VERB
gs-3751	363	9	scfas	scfas	NOUN
gs-3751	363	10	in	in	ADP
gs-3751	363	11	mice	mouse	NOUN
gs-3751	363	12	,	,	PUNCT
gs-3751	363	13	but	but	CCONJ
gs-3751	363	14	similar	similar	ADJ
gs-3751	363	15	interventions	intervention	NOUN
gs-3751	363	16	in	in	ADP
gs-3751	363	17	humans	human	NOUN
gs-3751	363	18	yield	yield	VERB
gs-3751	363	19	inconsistent	inconsistent	ADJ
gs-3751	363	20	results	result	NOUN
gs-3751	363	21	due	due	ADJ
gs-3751	363	22	to	to	PART
gs-3751	363	23	baseline	baseline	VERB
gs-3751	363	24	microbiota	microbiota	NOUN
gs-3751	363	25	variability	variability	NOUN
gs-3751	363	26	.	.	PUNCT
gs-3751	364	1	sex	sex	NOUN
gs-3751	364	2	differences	difference	NOUN
gs-3751	364	3	further	far	ADV
gs-3751	364	4	complicate	complicate	VERB
gs-3751	364	5	efficacy	efficacy	NOUN
gs-3751	364	6	,	,	PUNCT
gs-3751	364	7	as	as	SCONJ
gs-3751	364	8	estrogen	estrogen	NOUN
gs-3751	364	9	modulates	modulate	NOUN
gs-3751	364	10	gut	gut	VERB
gs-3751	364	11	permeability	permeability	NOUN
gs-3751	364	12	and	and	CCONJ
gs-3751	364	13	microbial	microbial	ADJ
gs-3751	364	14	composition	composition	NOUN
gs-3751	364	15	,	,	PUNCT
gs-3751	364	16	yet	yet	CCONJ
gs-3751	364	17	most	most	ADJ
gs-3751	364	18	trials	trial	NOUN
gs-3751	364	19	overlook	overlook	VERB
gs-3751	364	20	gender	gender	NOUN
gs-3751	364	21	-	-	PUNCT
gs-3751	364	22	specific	specific	ADJ
gs-3751	364	23	responses	response	NOUN
gs-3751	364	24	.	.	PUNCT
gs-3751	365	1	future	future	ADJ
gs-3751	365	2	research	research	NOUN
gs-3751	365	3	must	must	AUX
gs-3751	365	4	prioritize	prioritize	VERB
gs-3751	365	5	longitudinal	longitudinal	ADJ
gs-3751	365	6	studies	study	NOUN
gs-3751	365	7	to	to	PART
gs-3751	365	8	establish	establish	VERB
gs-3751	365	9	causality	causality	NOUN
gs-3751	365	10	between	between	ADP
gs-3751	365	11	dysbiosis	dysbiosis	NOUN
gs-3751	365	12	and	and	CCONJ
gs-3751	365	13	neurodegeneration	neurodegeneration	NOUN
gs-3751	365	14	.	.	PUNCT
gs-3751	366	1	the	the	DET
gs-3751	366	2	alzheimer	alzheimer	PROPN
gs-3751	366	3	’s	’s	PART
gs-3751	366	4	gut	gut	PROPN
gs-3751	366	5	microbiome	microbiome	NOUN
gs-3751	366	6	project	project	NOUN
gs-3751	366	7	,	,	PUNCT
gs-3751	366	8	a	a	DET
gs-3751	366	9	multi	multi	ADJ
gs-3751	366	10	-	-	ADJ
gs-3751	366	11	center	center	ADJ
gs-3751	366	12	initiative	initiative	NOUN
gs-3751	366	13	,	,	PUNCT
gs-3751	366	14	aims	aim	VERB
gs-3751	366	15	to	to	PART
gs-3751	366	16	profile	profile	VERB
gs-3751	366	17	microbial	microbial	ADJ
gs-3751	366	18	changes	change	NOUN
gs-3751	366	19	across	across	ADP
gs-3751	366	20	ad	ad	NOUN
gs-3751	366	21	stages	stage	NOUN
gs-3751	366	22	and	and	CCONJ
gs-3751	366	23	identify	identify	VERB
gs-3751	366	24	metabolite	metabolite	NOUN
gs-3751	366	25	biomarkers	biomarker	NOUN
gs-3751	366	26	.	.	PUNCT
gs-3751	367	1	similarly	similarly	ADV
gs-3751	367	2	,	,	PUNCT
gs-3751	367	3	ai	ai	ADJ
gs-3751	367	4	-	-	PUNCT
gs-3751	367	5	driven	drive	VERB
gs-3751	367	6	microbiome	microbiome	NOUN
gs-3751	367	7	analysis	analysis	NOUN
gs-3751	367	8	,	,	PUNCT
gs-3751	367	9	as	as	SCONJ
gs-3751	367	10	pioneered	pioneer	VERB
gs-3751	367	11	by	by	ADP
gs-3751	367	12	maude	maude	PROPN
gs-3751	367	13	david	david	PROPN
gs-3751	367	14	,	,	PUNCT
gs-3751	367	15	could	could	AUX
gs-3751	367	16	uncover	uncover	VERB
gs-3751	367	17	microbial	microbial	ADJ
gs-3751	367	18	signatures	signature	NOUN
gs-3751	367	19	predictive	predictive	ADJ
gs-3751	367	20	of	of	ADP
gs-3751	367	21	pd	pd	PROPN
gs-3751	367	22	progression	progression	NOUN
gs-3751	367	23	.	.	PUNCT
gs-3751	368	1	combining	combine	VERB
gs-3751	368	2	these	these	DET
gs-3751	368	3	approaches	approach	NOUN
gs-3751	368	4	with	with	ADP
gs-3751	368	5	advanced	advanced	ADJ
gs-3751	368	6	neuroimaging	neuroimaging	NOUN
gs-3751	368	7	techniques	technique	NOUN
gs-3751	368	8	—	—	PUNCT
gs-3751	368	9	such	such	ADJ
gs-3751	368	10	as	as	ADP
gs-3751	368	11	pet	pet	ADJ
gs-3751	368	12	scans	scan	NOUN
gs-3751	368	13	for	for	ADP
gs-3751	368	14	α	α	NOUN
gs-3751	368	15	-	-	PUNCT
gs-3751	368	16	synuclein	synuclein	NOUN
gs-3751	368	17	or	or	CCONJ
gs-3751	368	18	tau	tau	NOUN
gs-3751	368	19	—	—	PUNCT
gs-3751	368	20	will	will	AUX
gs-3751	368	21	enable	enable	VERB
gs-3751	368	22	real	real	ADJ
gs-3751	368	23	-	-	PUNCT
gs-3751	368	24	time	time	NOUN
gs-3751	368	25	monitoring	monitoring	NOUN
gs-3751	368	26	of	of	ADP
gs-3751	368	27	gut	gut	NOUN
gs-3751	368	28	-	-	PUNCT
gs-3751	368	29	brain	brain	NOUN
gs-3751	368	30	interactions	interaction	NOUN
gs-3751	368	31	.	.	PUNCT
gs-3751	369	1	the	the	DET
gs-3751	369	2	gut	gut	NOUN
gs-3751	369	3	-	-	PUNCT
gs-3751	369	4	brain	brain	NOUN
gs-3751	369	5	axis	axis	NOUN
gs-3751	369	6	is	be	AUX
gs-3751	369	7	a	a	DET
gs-3751	369	8	dynamic	dynamic	ADJ
gs-3751	369	9	interface	interface	NOUN
gs-3751	369	10	where	where	SCONJ
gs-3751	369	11	microbial	microbial	ADJ
gs-3751	369	12	metabolites	metabolite	NOUN
gs-3751	369	13	,	,	PUNCT
gs-3751	369	14	immune	immune	ADJ
gs-3751	369	15	signals	signal	NOUN
gs-3751	369	16	,	,	PUNCT
gs-3751	369	17	and	and	CCONJ
gs-3751	369	18	neural	neural	ADJ
gs-3751	369	19	pathways	pathway	NOUN
gs-3751	369	20	converge	converge	VERB
gs-3751	369	21	to	to	ADP
gs-3751	369	22	influence	influence	NOUN
gs-3751	369	23	neurodegeneration	neurodegeneration	NOUN
gs-3751	369	24	.	.	PUNCT
gs-3751	370	1	in	in	ADP
gs-3751	370	2	ad	ad	NOUN
gs-3751	370	3	and	and	CCONJ
gs-3751	370	4	pd	pd	NOUN
gs-3751	370	5	,	,	PUNCT
gs-3751	370	6	dysbiosis	dysbiosis	NOUN
gs-3751	370	7	amplifies	amplify	VERB
gs-3751	370	8	neuroinflammation	neuroinflammation	NOUN
gs-3751	370	9	,	,	PUNCT
gs-3751	370	10	protein	protein	NOUN
gs-3751	370	11	misfolding	misfolding	NOUN
gs-3751	370	12	,	,	PUNCT
gs-3751	370	13	and	and	CCONJ
gs-3751	370	14	neuronal	neuronal	ADJ
gs-3751	370	15	death	death	NOUN
gs-3751	370	16	,	,	PUNCT
gs-3751	370	17	creating	create	VERB
gs-3751	370	18	a	a	DET
gs-3751	370	19	vicious	vicious	ADJ
gs-3751	370	20	cycle	cycle	NOUN
gs-3751	370	21	that	that	PRON
gs-3751	370	22	accelerates	accelerate	VERB
gs-3751	370	23	disease	disease	NOUN
gs-3751	370	24	progression	progression	NOUN
gs-3751	370	25	.	.	PUNCT
gs-3751	371	1	emerging	emerge	VERB
gs-3751	371	2	therapies	therapy	NOUN
gs-3751	371	3	,	,	PUNCT
gs-3751	371	4	from	from	ADP
gs-3751	371	5	fmt	fmt	NOUN
gs-3751	371	6	to	to	ADP
gs-3751	371	7	metabolite	metabolite	NOUN
gs-3751	371	8	inhibitors	inhibitor	NOUN
gs-3751	371	9	,	,	PUNCT
gs-3751	371	10	offer	offer	VERB
gs-3751	371	11	hope	hope	NOUN
gs-3751	371	12	for	for	ADP
gs-3751	371	13	disrupting	disrupt	VERB
gs-3751	371	14	this	this	DET
gs-3751	371	15	cycle	cycle	NOUN
gs-3751	371	16	,	,	PUNCT
gs-3751	371	17	but	but	CCONJ
gs-3751	371	18	their	their	PRON
gs-3751	371	19	success	success	NOUN
gs-3751	371	20	hinges	hinge	VERB
gs-3751	371	21	on	on	ADP
gs-3751	371	22	personalized	personalized	ADJ
gs-3751	371	23	approaches	approach	NOUN
gs-3751	371	24	that	that	PRON
gs-3751	371	25	account	account	VERB
gs-3751	371	26	for	for	ADP
gs-3751	371	27	individual	individual	ADJ
gs-3751	371	28	microbiome	microbiome	NOUN
gs-3751	371	29	profiles	profile	NOUN
gs-3751	371	30	.	.	PUNCT
gs-3751	372	1	as	as	ADP
gs-3751	372	2	our	our	PRON
gs-3751	372	3	understanding	understanding	NOUN
gs-3751	372	4	of	of	ADP
gs-3751	372	5	the	the	DET
gs-3751	372	6	gba	gba	PROPN
gs-3751	372	7	deepens	deepen	NOUN
gs-3751	372	8	,	,	PUNCT
gs-3751	372	9	integrating	integrate	VERB
gs-3751	372	10	microbiome	microbiome	ADJ
gs-3751	372	11	science	science	NOUN
gs-3751	372	12	into	into	ADP
gs-3751	372	13	neurology	neurology	NOUN
gs-3751	372	14	may	may	AUX
gs-3751	372	15	revolutionize	revolutionize	VERB
gs-3751	372	16	the	the	DET
gs-3751	372	17	treatment	treatment	NOUN
gs-3751	372	18	of	of	ADP
gs-3751	372	19	neurodegenerative	neurodegenerative	ADJ
gs-3751	372	20	disorders	disorder	NOUN
gs-3751	372	21	,	,	PUNCT
gs-3751	372	22	shifting	shift	VERB
gs-3751	372	23	the	the	DET
gs-3751	372	24	paradigm	paradigm	NOUN
gs-3751	372	25	from	from	ADP
gs-3751	372	26	symptom	symptom	NOUN
gs-3751	372	27	management	management	NOUN
gs-3751	372	28	to	to	ADP
gs-3751	372	29	prevention	prevention	NOUN
gs-3751	372	30	and	and	CCONJ
gs-3751	372	31	cure	cure	NOUN
gs-3751	372	32	.	.	PUNCT
gs-3751	373	1	georgian	georgian	ADJ
gs-3751	373	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3751	373	3	მეცნიერები	მეცნიერები	NOUN
gs-3751	373	4	ტ.	ტ.	VERB
gs-3751	373	5	7	7	NUM
gs-3751	373	6	n	n	DET
gs-3751	373	7	2	2	NUM
gs-3751	373	8	,	,	PUNCT
gs-3751	373	9	2025	2025	NUM
gs-3751	373	10	350	350	NUM
gs-3751	373	11	microbiome	microbiome	ADJ
gs-3751	373	12	heterogeneity	heterogeneity	NOUN
gs-3751	373	13	:	:	PUNCT
gs-3751	373	14	geographic	geographic	ADJ
gs-3751	373	15	and	and	CCONJ
gs-3751	373	16	dietary	dietary	ADJ
gs-3751	373	17	variations	variation	NOUN
gs-3751	373	18	confound	confound	VERB
gs-3751	373	19	interventions	intervention	NOUN
gs-3751	373	20	.	.	PUNCT
gs-3751	374	1	for	for	ADP
gs-3751	374	2	example	example	NOUN
gs-3751	374	3	,	,	PUNCT
gs-3751	374	4	bifidobacterium	bifidobacterium	NOUN
gs-3751	374	5	dominates	dominate	VERB
gs-3751	374	6	asian	asian	ADJ
gs-3751	374	7	gut	gut	NOUN
gs-3751	374	8	microbiomes	microbiome	NOUN
gs-3751	374	9	but	but	CCONJ
gs-3751	374	10	is	be	AUX
gs-3751	374	11	scarce	scarce	ADJ
gs-3751	374	12	in	in	ADP
gs-3751	374	13	western	western	ADJ
gs-3751	374	14	populations	population	NOUN
gs-3751	374	15	,	,	PUNCT
gs-3751	374	16	affecting	affect	VERB
gs-3751	374	17	probiotic	probiotic	ADJ
gs-3751	374	18	trial	trial	NOUN
gs-3751	374	19	generalizability	generalizability	NOUN
gs-3751	374	20	.	.	PUNCT
gs-3751	375	1	sex	sex	NOUN
gs-3751	375	2	-	-	PUNCT
gs-3751	375	3	specific	specific	ADJ
gs-3751	375	4	responses	response	NOUN
gs-3751	375	5	:	:	PUNCT
gs-3751	375	6	estrogen	estrogen	NOUN
gs-3751	375	7	enhances	enhance	VERB
gs-3751	375	8	gut	gut	NOUN
gs-3751	375	9	barrier	barrier	NOUN
gs-3751	375	10	function	function	NOUN
gs-3751	375	11	via	via	ADP
gs-3751	375	12	occludin	occludin	NOUN
gs-3751	375	13	expression	expression	NOUN
gs-3751	375	14	,	,	PUNCT
gs-3751	375	15	yet	yet	ADV
gs-3751	375	16	80	80	NUM
gs-3751	375	17	%	%	NOUN
gs-3751	375	18	of	of	ADP
gs-3751	375	19	pd	pd	PROPN
gs-3751	375	20	trials	trial	NOUN
gs-3751	375	21	fail	fail	VERB
gs-3751	375	22	to	to	PART
gs-3751	375	23	stratify	stratify	VERB
gs-3751	375	24	by	by	ADP
gs-3751	375	25	sex	sex	NOUN
gs-3751	375	26	.	.	PUNCT
gs-3751	376	1	female	female	ADJ
gs-3751	376	2	ad	ad	NOUN
gs-3751	376	3	mice	mouse	NOUN
gs-3751	376	4	show	show	VERB
gs-3751	376	5	greater	great	ADJ
gs-3751	376	6	scfa	scfa	ADJ
gs-3751	376	7	benefits	benefit	NOUN
gs-3751	376	8	than	than	ADP
gs-3751	376	9	males	male	NOUN
gs-3751	376	10	,	,	PUNCT
gs-3751	376	11	suggesting	suggest	VERB
gs-3751	376	12	personalized	personalized	ADJ
gs-3751	376	13	approaches	approach	NOUN
gs-3751	376	14	are	be	AUX
gs-3751	376	15	critical	critical	ADJ
gs-3751	376	16	.	.	PUNCT
gs-3751	377	1	longitudinal	longitudinal	ADJ
gs-3751	377	2	biomarkers	biomarker	NOUN
gs-3751	377	3	:	:	PUNCT
gs-3751	377	4	the	the	DET
gs-3751	377	5	gut	gut	NOUN
gs-3751	377	6	microbiome	microbiome	NOUN
gs-3751	377	7	aging	age	VERB
gs-3751	377	8	clock	clock	NOUN
gs-3751	377	9	,	,	PUNCT
gs-3751	377	10	a	a	DET
gs-3751	377	11	machine	machine	NOUN
gs-3751	377	12	learning	learn	VERB
gs-3751	377	13	model	model	NOUN
gs-3751	377	14	,	,	PUNCT
gs-3751	377	15	predicts	predict	VERB
gs-3751	377	16	brain	brain	NOUN
gs-3751	377	17	age	age	NOUN
gs-3751	377	18	with	with	ADP
gs-3751	377	19	85	85	NUM
gs-3751	377	20	%	%	NOUN
gs-3751	377	21	accuracy	accuracy	NOUN
gs-3751	377	22	using	use	VERB
gs-3751	377	23	microbial	microbial	ADJ
gs-3751	377	24	taxa	taxa	NOUN
gs-3751	377	25	like	like	ADP
gs-3751	377	26	akkermansia	akkermansia	NOUN
gs-3751	377	27	and	and	CCONJ
gs-3751	377	28	ruminococcus	ruminococcus	NOUN
gs-3751	377	29	.	.	PUNCT
gs-3751	378	1	validating	validate	VERB
gs-3751	378	2	such	such	ADJ
gs-3751	378	3	tools	tool	NOUN
gs-3751	378	4	could	could	AUX
gs-3751	378	5	enable	enable	VERB
gs-3751	378	6	early	early	ADJ
gs-3751	378	7	intervention	intervention	NOUN
gs-3751	378	8	.	.	PUNCT
gs-3751	379	1	crispr	crispr	ADJ
gs-3751	379	2	-	-	PUNCT
gs-3751	379	3	microbiome	microbiome	NOUN
gs-3751	379	4	editing	editing	NOUN
gs-3751	379	5	:	:	PUNCT
gs-3751	379	6	engineered	engineer	VERB
gs-3751	379	7	bacteroides	bacteroide	NOUN
gs-3751	379	8	thetaiotaomicron	thetaiotaomicron	ADV
gs-3751	379	9	expressing	express	VERB
gs-3751	379	10	aβ	aβ	ADP
gs-3751	379	11	antibodies	antibody	NOUN
gs-3751	379	12	reduced	reduce	VERB
gs-3751	379	13	plaque	plaque	NOUN
gs-3751	379	14	burden	burden	NOUN
gs-3751	379	15	in	in	ADP
gs-3751	379	16	mice	mouse	NOUN
gs-3751	379	17	by	by	ADP
gs-3751	379	18	70	70	NUM
gs-3751	379	19	%	%	NOUN
gs-3751	379	20	,	,	PUNCT
gs-3751	379	21	pioneering	pioneer	VERB
gs-3751	379	22	live	live	ADJ
gs-3751	379	23	biotherapeutics	biotherapeutic	NOUN
gs-3751	379	24	for	for	ADP
gs-3751	379	25	neurodegeneration	neurodegeneration	NOUN
gs-3751	379	26	.	.	PUNCT
gs-3751	380	1	conclusions	conclusion	NOUN
gs-3751	380	2	:	:	PUNCT
gs-3751	380	3			VERB
gs-3751	380	4	the	the	DET
gs-3751	380	5	gut	gut	NOUN
gs-3751	380	6	-	-	PUNCT
gs-3751	380	7	brain	brain	NOUN
gs-3751	380	8	axis	axis	NOUN
gs-3751	380	9	is	be	AUX
gs-3751	380	10	a	a	DET
gs-3751	380	11	linchpin	linchpin	NOUN
gs-3751	380	12	in	in	ADP
gs-3751	380	13	neurodegenerative	neurodegenerative	ADJ
gs-3751	380	14	disease	disease	NOUN
gs-3751	380	15	,	,	PUNCT
gs-3751	380	16	offering	offer	VERB
gs-3751	380	17	unprecedented	unprecedented	ADJ
gs-3751	380	18	opportunities	opportunity	NOUN
gs-3751	380	19	for	for	ADP
gs-3751	380	20	intervention	intervention	NOUN
gs-3751	380	21	.	.	PUNCT
gs-3751	381	1	while	while	SCONJ
gs-3751	381	2	probiotics	probiotic	NOUN
gs-3751	381	3	,	,	PUNCT
gs-3751	381	4	fmt	fmt	NOUN
gs-3751	381	5	,	,	PUNCT
gs-3751	381	6	and	and	CCONJ
gs-3751	381	7	metabolite	metabolite	NOUN
gs-3751	381	8	inhibitors	inhibitor	NOUN
gs-3751	381	9	show	show	VERB
gs-3751	381	10	promise	promise	NOUN
gs-3751	381	11	,	,	PUNCT
gs-3751	381	12	their	their	PRON
gs-3751	381	13	success	success	NOUN
gs-3751	381	14	hinges	hinge	VERB
gs-3751	381	15	on	on	ADP
gs-3751	381	16	precision	precision	NOUN
gs-3751	381	17	medicine	medicine	NOUN
gs-3751	381	18	approaches	approach	NOUN
gs-3751	381	19	that	that	PRON
gs-3751	381	20	account	account	VERB
gs-3751	381	21	for	for	ADP
gs-3751	381	22	individual	individual	ADJ
gs-3751	381	23	microbiome	microbiome	NOUN
gs-3751	381	24	signatures	signature	NOUN
gs-3751	381	25	.	.	PUNCT
gs-3751	382	1	future	future	ADJ
gs-3751	382	2	research	research	NOUN
gs-3751	382	3	must	must	AUX
gs-3751	382	4	bridge	bridge	VERB
gs-3751	382	5	gaps	gap	NOUN
gs-3751	382	6	between	between	ADP
gs-3751	382	7	animal	animal	NOUN
gs-3751	382	8	models	model	NOUN
gs-3751	382	9	and	and	CCONJ
gs-3751	382	10	human	human	ADJ
gs-3751	382	11	trials	trial	NOUN
gs-3751	382	12	,	,	PUNCT
gs-3751	382	13	prioritize	prioritize	VERB
gs-3751	382	14	sex	sex	NOUN
gs-3751	382	15	-	-	PUNCT
gs-3751	382	16	specific	specific	ADJ
gs-3751	382	17	analyses	analysis	NOUN
gs-3751	382	18	,	,	PUNCT
gs-3751	382	19	and	and	CCONJ
gs-3751	382	20	leverage	leverage	NOUN
gs-3751	382	21	ai	ai	VERB
gs-3751	382	22	for	for	ADP
gs-3751	382	23	microbiome	microbiome	NOUN
gs-3751	382	24	decoding	decoding	NOUN
gs-3751	382	25	.	.	PUNCT
gs-3751	383	1	by	by	ADP
gs-3751	383	2	targeting	target	VERB
gs-3751	383	3	the	the	DET
gs-3751	383	4	gba	gba	NOUN
gs-3751	383	5	,	,	PUNCT
gs-3751	383	6	we	we	PRON
gs-3751	383	7	may	may	AUX
gs-3751	383	8	transform	transform	VERB
gs-3751	383	9	neurodegenerative	neurodegenerative	ADJ
gs-3751	383	10	disease	disease	NOUN
gs-3751	383	11	management	management	NOUN
gs-3751	383	12	from	from	ADP
gs-3751	383	13	reactive	reactive	NOUN
gs-3751	383	14	to	to	ADP
gs-3751	383	15	proactive	proactive	ADJ
gs-3751	383	16	,	,	PUNCT
gs-3751	383	17	delaying	delaying	NOUN
gs-3751	383	18	—	—	PUNCT
gs-3751	383	19	or	or	CCONJ
gs-3751	383	20	even	even	ADV
gs-3751	383	21	preventing	prevent	VERB
gs-3751	383	22	—	—	PUNCT
gs-3751	383	23	pathology	pathology	NOUN
gs-3751	383	24	before	before	SCONJ
gs-3751	383	25	cns	cns	PROPN
gs-3751	383	26	symptoms	symptom	NOUN
gs-3751	383	27	emerge	emerge	VERB
gs-3751	383	28	.	.	PUNCT
gs-3751	384	1			VERB
gs-3751	384	2	microbiome	microbiome	NOUN
gs-3751	384	3	-	-	PUNCT
gs-3751	384	4	targeted	target	VERB
gs-3751	384	5	therapies	therapy	NOUN
gs-3751	384	6	have	have	VERB
gs-3751	384	7	significant	significant	ADJ
gs-3751	384	8	potential	potential	NOUN
gs-3751	384	9	in	in	ADP
gs-3751	384	10	being	be	AUX
gs-3751	384	11	the	the	DET
gs-3751	384	12	adjunctive	adjunctive	ADJ
gs-3751	384	13	treatment	treatment	NOUN
gs-3751	384	14	approach	approach	NOUN
gs-3751	384	15	for	for	ADP
gs-3751	384	16	neurodegenerative	neurodegenerative	ADJ
gs-3751	384	17	diseases	disease	NOUN
gs-3751	384	18	.	.	PUNCT
gs-3751	385	1	that	that	PRON
gs-3751	385	2	said	say	VERB
gs-3751	385	3	,	,	PUNCT
gs-3751	385	4	until	until	SCONJ
gs-3751	385	5	further	far	ADV
gs-3751	385	6	supporting	support	VERB
gs-3751	385	7	evidence	evidence	NOUN
gs-3751	385	8	is	be	AUX
gs-3751	385	9	available	available	ADJ
gs-3751	385	10	,	,	PUNCT
gs-3751	385	11	primary	primary	ADJ
gs-3751	385	12	treatment	treatment	NOUN
gs-3751	385	13	is	be	AUX
gs-3751	385	14	the	the	DET
gs-3751	385	15	standard	standard	ADJ
gs-3751	385	16	treatment	treatment	NOUN
gs-3751	385	17	additionally	additionally	ADV
gs-3751	385	18	with	with	ADP
gs-3751	385	19	secondary	secondary	ADJ
gs-3751	385	20	approach	approach	NOUN
gs-3751	385	21	.	.	PUNCT
gs-3751	386	1			VERB
gs-3751	386	2	despite	despite	SCONJ
gs-3751	386	3	promising	promising	ADJ
gs-3751	386	4	findings	finding	NOUN
gs-3751	386	5	,	,	PUNCT
gs-3751	386	6	the	the	DET
gs-3751	386	7	precise	precise	ADJ
gs-3751	386	8	mechanisms	mechanism	NOUN
gs-3751	386	9	of	of	ADP
gs-3751	386	10	microbiome	microbiome	NOUN
gs-3751	386	11	-	-	PUNCT
gs-3751	386	12	brain	brain	NOUN
gs-3751	386	13	interactions	interaction	NOUN
gs-3751	386	14	remain	remain	VERB
gs-3751	386	15	unclear	unclear	ADJ
gs-3751	386	16	,	,	PUNCT
gs-3751	386	17	and	and	CCONJ
gs-3751	386	18	longitudinal	longitudinal	ADJ
gs-3751	386	19	studies	study	NOUN
gs-3751	386	20	are	be	AUX
gs-3751	386	21	necessary	necessary	ADJ
gs-3751	386	22	to	to	PART
gs-3751	386	23	clarify	clarify	VERB
gs-3751	386	24	causality	causality	NOUN
gs-3751	386	25	and	and	CCONJ
gs-3751	386	26	therapeutic	therapeutic	ADJ
gs-3751	386	27	viability	viability	NOUN
gs-3751	386	28	.	.	PUNCT
gs-3751	387	1	this	this	PRON
gs-3751	387	2	is	be	AUX
gs-3751	387	3	especially	especially	ADV
gs-3751	387	4	important	important	ADJ
gs-3751	387	5	in	in	ADP
gs-3751	387	6	neuroscience	neuroscience	NOUN
gs-3751	387	7	.	.	PUNCT
gs-3751	388	1	however	however	ADV
gs-3751	388	2	,	,	PUNCT
gs-3751	388	3	the	the	DET
gs-3751	388	4	development	development	NOUN
gs-3751	388	5	of	of	ADP
gs-3751	388	6	probiotics	probiotic	NOUN
gs-3751	388	7	,	,	PUNCT
gs-3751	388	8	dietary	dietary	ADJ
gs-3751	388	9	changes	change	NOUN
gs-3751	388	10	,	,	PUNCT
gs-3751	388	11	and	and	CCONJ
gs-3751	388	12	the	the	DET
gs-3751	388	13	transfer	transfer	NOUN
gs-3751	388	14	of	of	ADP
gs-3751	388	15	fecal	fecal	ADJ
gs-3751	388	16	microbiota	microbiota	NOUN
gs-3751	388	17	through	through	ADP
gs-3751	388	18	transplantation	transplantation	NOUN
gs-3751	388	19	opens	open	VERB
gs-3751	388	20	up	up	ADP
gs-3751	388	21	a	a	DET
gs-3751	388	22	new	new	ADJ
gs-3751	388	23	path	path	NOUN
gs-3751	388	24	to	to	ADP
gs-3751	388	25	improving	improve	VERB
gs-3751	388	26	patient	patient	ADJ
gs-3751	388	27	outcomes	outcome	NOUN
gs-3751	388	28	and	and	CCONJ
gs-3751	388	29	controlling	control	VERB
gs-3751	388	30	neurodegeneration	neurodegeneration	NOUN
gs-3751	388	31	.	.	PUNCT
gs-3751	389	1			VERB
gs-3751	389	2	future	future	ADJ
gs-3751	389	3	research	research	NOUN
gs-3751	389	4	should	should	AUX
gs-3751	389	5	focus	focus	VERB
gs-3751	389	6	on	on	ADP
gs-3751	389	7	developing	develop	VERB
gs-3751	389	8	targeted	target	VERB
gs-3751	389	9	therapies	therapy	NOUN
gs-3751	389	10	for	for	ADP
gs-3751	389	11	the	the	DET
gs-3751	389	12	microbiome	microbiome	NOUN
gs-3751	389	13	,	,	PUNCT
gs-3751	389	14	designing	design	VERB
gs-3751	389	15	treatments	treatment	NOUN
gs-3751	389	16	specifically	specifically	ADV
gs-3751	389	17	for	for	ADP
gs-3751	389	18	specific	specific	ADJ
gs-3751	389	19	micro	micro	NOUN
gs-3751	389	20	-	-	NOUN
gs-3751	389	21	biomes	biome	NOUN
gs-3751	389	22	,	,	PUNCT
gs-3751	389	23	and	and	CCONJ
gs-3751	389	24	examining	examine	VERB
gs-3751	389	25	the	the	DET
gs-3751	389	26	long	long	ADJ
gs-3751	389	27	-	-	PUNCT
gs-3751	389	28	term	term	NOUN
gs-3751	389	29	effects	effect	NOUN
gs-3751	389	30	of	of	ADP
gs-3751	389	31	changing	change	VERB
gs-3751	389	32	these	these	DET
gs-3751	389	33	microorganisms	microorganism	NOUN
gs-3751	389	34	on	on	ADP
gs-3751	389	35	brain	brain	NOUN
gs-3751	389	36	function	function	NOUN
gs-3751	389	37	.	.	PUNCT
gs-3751	390	1	recommendations	recommendation	NOUN
gs-3751	390	2	to	to	PART
gs-3751	390	3	harness	harness	VERB
gs-3751	390	4	the	the	DET
gs-3751	390	5	gut	gut	NOUN
gs-3751	390	6	-	-	PUNCT
gs-3751	390	7	brain	brain	NOUN
gs-3751	390	8	axis	axis	NOUN
gs-3751	390	9	’s	’s	PART
gs-3751	390	10	therapeutic	therapeutic	ADJ
gs-3751	390	11	potential	potential	NOUN
gs-3751	390	12	,	,	PUNCT
gs-3751	390	13	a	a	DET
gs-3751	390	14	multidisciplinary	multidisciplinary	ADJ
gs-3751	390	15	approach	approach	NOUN
gs-3751	390	16	—	—	PUNCT
gs-3751	390	17	spanning	span	VERB
gs-3751	390	18	precision	precision	NOUN
gs-3751	390	19	medicine	medicine	NOUN
gs-3751	390	20	,	,	PUNCT
gs-3751	390	21	ai	ai	ADJ
gs-3751	390	22	-	-	PUNCT
gs-3751	390	23	driven	drive	VERB
gs-3751	390	24	research	research	NOUN
gs-3751	390	25	,	,	PUNCT
gs-3751	390	26	and	and	CCONJ
gs-3751	390	27	global	global	ADJ
gs-3751	390	28	policy	policy	NOUN
gs-3751	390	29	reform	reform	NOUN
gs-3751	390	30	—	—	PUNCT
gs-3751	390	31	is	be	AUX
gs-3751	390	32	essential	essential	ADJ
gs-3751	390	33	.	.	PUNCT
gs-3751	391	1	prioritizing	prioritize	VERB
gs-3751	391	2	microbiome	microbiome	ADJ
gs-3751	391	3	health	health	NOUN
gs-3751	391	4	must	must	AUX
gs-3751	391	5	become	become	VERB
gs-3751	391	6	a	a	DET
gs-3751	391	7	cornerstone	cornerstone	NOUN
gs-3751	391	8	of	of	ADP
gs-3751	391	9	neurodegenerative	neurodegenerative	ADJ
gs-3751	391	10	disease	disease	NOUN
gs-3751	391	11	prevention	prevention	NOUN
gs-3751	391	12	,	,	PUNCT
gs-3751	391	13	with	with	ADP
gs-3751	391	14	innovations	innovation	NOUN
gs-3751	391	15	like	like	ADP
gs-3751	391	16	fmt	fmt	VERB
gs-3751	391	17	and	and	CCONJ
gs-3751	391	18	crispr	crispr	ADV
gs-3751	391	19	-	-	PUNCT
gs-3751	391	20	edited	edit	VERB
gs-3751	391	21	probiotics	probiotic	NOUN
gs-3751	391	22	paving	pave	VERB
gs-3751	391	23	the	the	DET
gs-3751	391	24	way	way	NOUN
gs-3751	391	25	for	for	ADP
gs-3751	391	26	curative	curative	ADJ
gs-3751	391	27	strategies	strategy	NOUN
gs-3751	391	28	.	.	PUNCT
gs-3751	392	1	by	by	ADP
gs-3751	392	2	addressing	address	VERB
gs-3751	392	3	current	current	ADJ
gs-3751	392	4	challenges	challenge	NOUN
gs-3751	392	5	(	(	PUNCT
gs-3751	392	6	heterogeneity	heterogeneity	NOUN
gs-3751	392	7	,	,	PUNCT
gs-3751	392	8	sex	sex	NOUN
gs-3751	392	9	biases	bias	NOUN
gs-3751	392	10	,	,	PUNCT
gs-3751	392	11	and	and	CCONJ
gs-3751	392	12	translational	translational	ADJ
gs-3751	392	13	gaps	gap	NOUN
gs-3751	392	14	)	)	PUNCT
gs-3751	392	15	,	,	PUNCT
gs-3751	392	16	we	we	PRON
gs-3751	392	17	can	can	AUX
gs-3751	392	18	transform	transform	VERB
gs-3751	392	19	the	the	DET
gs-3751	392	20	gba	gba	NOUN
gs-3751	392	21	from	from	ADP
gs-3751	392	22	a	a	DET
gs-3751	392	23	scientific	scientific	ADJ
gs-3751	392	24	curiosity	curiosity	NOUN
gs-3751	392	25	into	into	ADP
gs-3751	392	26	a	a	DET
gs-3751	392	27	frontline	frontline	NOUN
gs-3751	392	28	defense	defense	NOUN
gs-3751	392	29	against	against	ADP
gs-3751	392	30	alzheimer	alzheimer	PROPN
gs-3751	392	31	’s	’s	PART
gs-3751	392	32	,	,	PUNCT
gs-3751	392	33	parkinson	parkinson	NOUN
gs-3751	392	34	’s	’s	PART
gs-3751	392	35	,	,	PUNCT
gs-3751	392	36	and	and	CCONJ
gs-3751	392	37	beyond	beyond	ADP
gs-3751	392	38	.	.	PUNCT
gs-3751	393	1	georgian	georgian	ADJ
gs-3751	393	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3751	393	3	მეცნიერები	მეცნიერები	NOUN
gs-3751	393	4	ტ.	ტ.	VERB
gs-3751	393	5	7	7	NUM
gs-3751	393	6	n	n	DET
gs-3751	393	7	2	2	NUM
gs-3751	393	8	,	,	PUNCT
gs-3751	393	9	2025	2025	NUM
gs-3751	393	10	351	351	NUM
gs-3751	393	11	references	reference	NOUN
gs-3751	393	12	1	1	NUM
gs-3751	393	13	.	.	PUNCT
gs-3751	393	14	aghamohammadi	aghamohammadi	PROPN
gs-3751	393	15	,	,	PUNCT
gs-3751	393	16	h.	h.	PROPN
gs-3751	393	17	,	,	PUNCT
gs-3751	393	18	zare	zare	PROPN
gs-3751	393	19	-	-	PUNCT
gs-3751	393	20	sadeghi	sadeghi	PROPN
gs-3751	393	21	,	,	PUNCT
gs-3751	393	22	a.	a.	NOUN
gs-3751	393	23	,	,	PUNCT
gs-3751	393	24	&	&	CCONJ
gs-3751	393	25	mohammadi	mohammadi	NOUN
gs-3751	393	26	,	,	PUNCT
gs-3751	393	27	m.	m.	NOUN
gs-3751	393	28	(	(	PUNCT
gs-3751	393	29	2023	2023	NUM
gs-3751	393	30	)	)	PUNCT
gs-3751	393	31	.	.	PUNCT
gs-3751	394	1	the	the	DET
gs-3751	394	2	effect	effect	NOUN
gs-3751	394	3	of	of	ADP
gs-3751	394	4	probiotics	probiotic	NOUN
gs-3751	394	5	on	on	ADP
gs-3751	394	6	cognitive	cognitive	ADJ
gs-3751	394	7	function	function	NOUN
gs-3751	394	8	in	in	ADP
gs-3751	394	9	patients	patient	NOUN
gs-3751	394	10	with	with	ADP
gs-3751	394	11	neurodegenerative	neurodegenerative	ADJ
gs-3751	394	12	diseases	disease	NOUN
gs-3751	394	13	:	:	PUNCT
gs-3751	394	14	a	a	DET
gs-3751	394	15	systematic	systematic	ADJ
gs-3751	394	16	review	review	NOUN
gs-3751	394	17	and	and	CCONJ
gs-3751	394	18	metaanalysis	metaanalysis	NOUN
gs-3751	394	19	.	.	PUNCT
gs-3751	395	1	neurobiology	neurobiology	NOUN
gs-3751	395	2	of	of	ADP
gs-3751	395	3	aging	aging	NOUN
gs-3751	395	4	,	,	PUNCT
gs-3751	395	5	123	123	NUM
gs-3751	395	6	,	,	PUNCT
gs-3751	395	7	85–98	85–98	NUM
gs-3751	395	8	.	.	NOUN
gs-3751	395	9	2	2	NUM
gs-3751	395	10	.	.	NUM
gs-3751	395	11	brown	brown	PROPN
gs-3751	395	12	,	,	PUNCT
gs-3751	395	13	r.	r.	PROPN
gs-3751	395	14	,	,	PUNCT
gs-3751	395	15	&	&	CCONJ
gs-3751	395	16	green	green	PROPN
gs-3751	395	17	,	,	PUNCT
gs-3751	395	18	d.	d.	PROPN
gs-3751	395	19	(	(	PUNCT
gs-3751	395	20	2024	2024	NUM
gs-3751	395	21	)	)	PUNCT
gs-3751	395	22	.	.	PUNCT
gs-3751	396	1	age	age	NOUN
gs-3751	396	2	-	-	PUNCT
gs-3751	396	3	related	relate	VERB
gs-3751	396	4	cognitive	cognitive	ADJ
gs-3751	396	5	decline	decline	NOUN
gs-3751	396	6	:	:	PUNCT
gs-3751	396	7	focus	focus	VERB
gs-3751	396	8	on	on	ADP
gs-3751	396	9	the	the	DET
gs-3751	396	10	microbiome	microbiome	NOUN
gs-3751	396	11	.	.	PUNCT
gs-3751	397	1	international	international	ADJ
gs-3751	397	2	journal	journal	NOUN
gs-3751	397	3	of	of	ADP
gs-3751	397	4	molecular	molecular	ADJ
gs-3751	397	5	sciences	science	NOUN
gs-3751	397	6	,	,	PUNCT
gs-3751	397	7	24(18	24(18	NUM
gs-3751	397	8	)	)	PUNCT
gs-3751	397	9	,	,	PUNCT
gs-3751	397	10	13680	13680	NUM
gs-3751	397	11	.	.	PUNCT
gs-3751	398	1	3	3	X
gs-3751	398	2	.	.	X
gs-3751	398	3	chui	chui	PROPN
gs-3751	398	4	,	,	PUNCT
gs-3751	398	5	z.	z.	PROPN
gs-3751	398	6	s.	s.	PROPN
gs-3751	398	7	w.	w.	PROPN
gs-3751	398	8	,	,	PUNCT
gs-3751	398	9	&	&	CCONJ
gs-3751	398	10	chiu	chiu	PROPN
gs-3751	398	11	,	,	PUNCT
gs-3751	398	12	h.	h.	PROPN
gs-3751	398	13	f.	f.	PROPN
gs-3751	398	14	k.	k.	PROPN
gs-3751	398	15	(	(	PUNCT
gs-3751	398	16	2024	2024	NUM
gs-3751	398	17	)	)	PUNCT
gs-3751	398	18	.	.	PUNCT
gs-3751	399	1	effects	effect	NOUN
gs-3751	399	2	of	of	ADP
gs-3751	399	3	microbiome	microbiome	NOUN
gs-3751	399	4	-	-	PUNCT
gs-3751	399	5	based	base	VERB
gs-3751	399	6	interventions	intervention	NOUN
gs-3751	399	7	on	on	ADP
gs-3751	399	8	neurodegenerative	neurodegenerative	ADJ
gs-3751	399	9	diseases	disease	NOUN
gs-3751	399	10	:	:	PUNCT
gs-3751	399	11	a	a	DET
gs-3751	399	12	systematic	systematic	ADJ
gs-3751	399	13	review	review	NOUN
gs-3751	399	14	and	and	CCONJ
gs-3751	399	15	meta	meta	ADJ
gs-3751	399	16	-	-	PUNCT
gs-3751	399	17	analysis	analysis	NOUN
gs-3751	399	18	.	.	PUNCT
gs-3751	400	1	scientific	scientific	ADJ
gs-3751	400	2	reports	report	NOUN
gs-3751	400	3	.	.	PUNCT
gs-3751	401	1	4	4	X
gs-3751	401	2	.	.	X
gs-3751	401	3	feng	feng	PROPN
gs-3751	401	4	,	,	PUNCT
gs-3751	401	5	y.	y.	PROPN
gs-3751	401	6	,	,	PUNCT
gs-3751	401	7	huang	huang	PROPN
gs-3751	401	8	,	,	PUNCT
gs-3751	401	9	y.	y.	PROPN
gs-3751	401	10	,	,	PUNCT
gs-3751	401	11	&	&	CCONJ
gs-3751	401	12	zhang	zhang	PROPN
gs-3751	401	13	,	,	PUNCT
gs-3751	401	14	x.	x.	NOUN
gs-3751	401	15	(	(	PUNCT
gs-3751	401	16	2023	2023	NUM
gs-3751	401	17	)	)	PUNCT
gs-3751	401	18	.	.	PUNCT
gs-3751	402	1	gut	gut	VERB
gs-3751	402	2	microbiota	microbiota	NOUN
gs-3751	402	3	modulation	modulation	NOUN
gs-3751	402	4	as	as	ADP
gs-3751	402	5	a	a	DET
gs-3751	402	6	therapeutic	therapeutic	ADJ
gs-3751	402	7	strategy	strategy	NOUN
gs-3751	402	8	in	in	ADP
gs-3751	402	9	alzheimer	alzheimer	PROPN
gs-3751	402	10	’s	’s	PART
gs-3751	402	11	and	and	CCONJ
gs-3751	402	12	parkinson	parkinson	NOUN
gs-3751	402	13	’s	’s	PART
gs-3751	402	14	diseases	disease	NOUN
gs-3751	402	15	.	.	PUNCT
gs-3751	403	1	frontiers	frontier	NOUN
gs-3751	403	2	in	in	ADP
gs-3751	403	3	aging	age	VERB
gs-3751	403	4	neuroscience	neuroscience	NOUN
gs-3751	403	5	,	,	PUNCT
gs-3751	403	6	15	15	NUM
gs-3751	403	7	,	,	PUNCT
gs-3751	403	8	article	article	NOUN
gs-3751	403	9	109987	109987	NUM
gs-3751	403	10	.	.	PUNCT
gs-3751	404	1	5	5	X
gs-3751	404	2	.	.	X
gs-3751	404	3	johnson	johnson	PROPN
gs-3751	404	4	,	,	PUNCT
gs-3751	404	5	l.	l.	PROPN
gs-3751	404	6	a.	a.	PROPN
gs-3751	404	7	,	,	PUNCT
gs-3751	404	8	&	&	CCONJ
gs-3751	404	9	torres	torres	PROPN
gs-3751	404	10	,	,	PUNCT
gs-3751	404	11	e.	e.	PROPN
gs-3751	404	12	r.	r.	PROPN
gs-3751	404	13	(	(	PUNCT
gs-3751	404	14	2024	2024	NUM
gs-3751	404	15	)	)	PUNCT
gs-3751	404	16	.	.	PUNCT
gs-3751	405	1	role	role	NOUN
gs-3751	405	2	of	of	ADP
gs-3751	405	3	the	the	DET
gs-3751	405	4	gut	gut	NOUN
gs-3751	405	5	microbiome	microbiome	NOUN
gs-3751	405	6	in	in	ADP
gs-3751	405	7	diet	diet	NOUN
gs-3751	405	8	and	and	CCONJ
gs-3751	405	9	exercise	exercise	NOUN
gs-3751	405	10	effects	effect	NOUN
gs-3751	405	11	on	on	ADP
gs-3751	405	12	cognition	cognition	NOUN
gs-3751	405	13	.	.	PUNCT
gs-3751	406	1	the	the	DET
gs-3751	406	2	journals	journal	NOUN
gs-3751	406	3	of	of	ADP
gs-3751	406	4	gerontology	gerontology	NOUN
gs-3751	406	5	:	:	PUNCT
gs-3751	406	6	series	series	PROPN
gs-3751	406	7	a	a	X
gs-3751	406	8	,	,	PUNCT
gs-3751	406	9	78(2	78(2	PROPN
gs-3751	406	10	)	)	PUNCT
gs-3751	406	11	,	,	PUNCT
gs-3751	406	12	195–204	195–204	NUM
gs-3751	406	13	.	.	PUNCT
gs-3751	407	1	6	6	NUM
gs-3751	407	2	.	.	X
gs-3751	407	3	aphkhazava	aphkhazava	PROPN
gs-3751	407	4	,	,	PUNCT
gs-3751	407	5	david	david	PROPN
gs-3751	407	6	,	,	PUNCT
gs-3751	407	7	nodar	nodar	NOUN
gs-3751	407	8	sulashvili	sulashvili	NOUN
gs-3751	407	9	,	,	PUNCT
gs-3751	407	10	and	and	CCONJ
gs-3751	407	11	jaba	jaba	PROPN
gs-3751	407	12	tkemaladze	tkemaladze	PROPN
gs-3751	407	13	.	.	PUNCT
gs-3751	408	1	2025	2025	NUM
gs-3751	408	2	.	.	PUNCT
gs-3751	409	1	“	"	PUNCT
gs-3751	409	2	stem	stem	NOUN
gs-3751	409	3	cell	cell	NOUN
gs-3751	409	4	systems	system	NOUN
gs-3751	409	5	and	and	CCONJ
gs-3751	409	6	regeneration	regeneration	NOUN
gs-3751	409	7	”	"	PUNCT
gs-3751	409	8	.	.	PUNCT
gs-3751	410	1	georgian	georgian	PROPN
gs-3751	410	2	scientists	scientist	NOUN
gs-3751	410	3	7	7	NUM
gs-3751	410	4	(	(	PUNCT
gs-3751	410	5	1):271	1):271	NUM
gs-3751	410	6	-	-	SYM
gs-3751	410	7	319	319	NUM
gs-3751	410	8	.	.	PUNCT
gs-3751	411	1	https://doi.org/10.52340/gs.2025.07.01.26	https://doi.org/10.52340/gs.2025.07.01.26	NOUN
gs-3751	411	2	.	.	NOUN
gs-3751	411	3	7	7	X
gs-3751	411	4	.	.	X
gs-3751	411	5	lee	lee	PROPN
gs-3751	411	6	,	,	PUNCT
gs-3751	411	7	s.	s.	PROPN
gs-3751	411	8	h.	h.	PROPN
gs-3751	411	9	,	,	PUNCT
gs-3751	411	10	&	&	CCONJ
gs-3751	411	11	park	park	PROPN
gs-3751	411	12	,	,	PUNCT
gs-3751	411	13	j.	j.	PROPN
gs-3751	411	14	h.	h.	PROPN
gs-3751	411	15	(	(	PUNCT
gs-3751	411	16	2024	2024	NUM
gs-3751	411	17	)	)	PUNCT
gs-3751	411	18	.	.	PUNCT
gs-3751	412	1	modulation	modulation	NOUN
gs-3751	412	2	of	of	ADP
gs-3751	412	3	gut	gut	NOUN
gs-3751	412	4	microbiota	microbiota	NOUN
gs-3751	412	5	through	through	ADP
gs-3751	412	6	dietary	dietary	ADJ
gs-3751	412	7	intervention	intervention	NOUN
gs-3751	412	8	in	in	ADP
gs-3751	412	9	neurodegenerative	neurodegenerative	ADJ
gs-3751	412	10	diseases	disease	NOUN
gs-3751	412	11	.	.	PUNCT
gs-3751	413	1	current	current	ADJ
gs-3751	413	2	nutrition	nutrition	NOUN
gs-3751	413	3	reports	report	NOUN
gs-3751	413	4	.	.	PUNCT
gs-3751	414	1	https://doi.org/10.1007/s13668-02400539-7	https://doi.org/10.1007/s13668-02400539-7	NOUN
gs-3751	414	2	8	8	NUM
gs-3751	414	3	.	.	PUNCT
gs-3751	415	1	li	li	PROPN
gs-3751	415	2	,	,	PUNCT
gs-3751	415	3	b.	b.	PROPN
gs-3751	415	4	,	,	PUNCT
gs-3751	415	5	&	&	CCONJ
gs-3751	415	6	wang	wang	PROPN
gs-3751	415	7	,	,	PUNCT
gs-3751	415	8	y.	y.	PROPN
gs-3751	415	9	(	(	PUNCT
gs-3751	415	10	2024	2024	NUM
gs-3751	415	11	)	)	PUNCT
gs-3751	415	12	.	.	PUNCT
gs-3751	416	1	therapeutics	therapeutic	NOUN
gs-3751	416	2	for	for	ADP
gs-3751	416	3	neurodegenerative	neurodegenerative	ADJ
gs-3751	416	4	diseases	disease	NOUN
gs-3751	416	5	by	by	ADP
gs-3751	416	6	targeting	target	VERB
gs-3751	416	7	the	the	DET
gs-3751	416	8	gut	gut	NOUN
gs-3751	416	9	microbiome	microbiome	NOUN
gs-3751	416	10	:	:	PUNCT
gs-3751	416	11	insights	insight	NOUN
gs-3751	416	12	from	from	ADP
gs-3751	416	13	preclinical	preclinical	ADJ
gs-3751	416	14	and	and	CCONJ
gs-3751	416	15	clinical	clinical	ADJ
gs-3751	416	16	studies	study	NOUN
gs-3751	416	17	.	.	PUNCT
gs-3751	417	1	translational	translational	ADJ
gs-3751	417	2	neurodegeneration	neurodegeneration	NOUN
gs-3751	417	3	.	.	PUNCT
gs-3751	418	1	9	9	X
gs-3751	418	2	.	.	X
gs-3751	418	3	smith	smith	PROPN
gs-3751	418	4	,	,	PUNCT
gs-3751	418	5	j.	j.	PROPN
gs-3751	418	6	,	,	PUNCT
gs-3751	418	7	&	&	CCONJ
gs-3751	418	8	doe	doe	PROPN
gs-3751	418	9	,	,	PUNCT
gs-3751	418	10	a.	a.	NOUN
gs-3751	418	11	(	(	PUNCT
gs-3751	418	12	2024	2024	NUM
gs-3751	418	13	)	)	PUNCT
gs-3751	418	14	.	.	PUNCT
gs-3751	419	1	gut	gut	NOUN
gs-3751	419	2	microbes	microbe	NOUN
gs-3751	419	3	associated	associate	VERB
gs-3751	419	4	with	with	ADP
gs-3751	419	5	neurodegenerative	neurodegenerative	ADJ
gs-3751	419	6	disorders	disorder	NOUN
gs-3751	419	7	:	:	PUNCT
gs-3751	419	8	a	a	DET
gs-3751	419	9	systematic	systematic	ADJ
gs-3751	419	10	review	review	NOUN
gs-3751	419	11	.	.	PUNCT
gs-3751	420	1	microorganisms	microorganism	NOUN
gs-3751	420	2	,	,	PUNCT
gs-3751	420	3	12(8	12(8	NUM
gs-3751	420	4	)	)	PUNCT
gs-3751	420	5	,	,	PUNCT
gs-3751	420	6	1735	1735	NUM
gs-3751	420	7	.	.	PUNCT
gs-3751	421	1	10	10	NUM
gs-3751	421	2	.	.	X
gs-3751	422	1	wang	wang	PROPN
gs-3751	422	2	,	,	PUNCT
gs-3751	422	3	h.	h.	PROPN
gs-3751	422	4	,	,	PUNCT
gs-3751	422	5	&	&	CCONJ
gs-3751	422	6	li	li	PROPN
gs-3751	422	7	,	,	PUNCT
gs-3751	422	8	q.	q.	PROPN
gs-3751	422	9	(	(	PUNCT
gs-3751	422	10	2024	2024	NUM
gs-3751	422	11	)	)	PUNCT
gs-3751	422	12	.	.	PUNCT
gs-3751	423	1	gut	gut	NOUN
gs-3751	423	2	-	-	PUNCT
gs-3751	423	3	brain	brain	NOUN
gs-3751	423	4	axis	axis	NOUN
gs-3751	423	5	and	and	CCONJ
gs-3751	423	6	neurodegeneration	neurodegeneration	NOUN
gs-3751	423	7	:	:	PUNCT
gs-3751	423	8	mechanisms	mechanism	NOUN
gs-3751	423	9	and	and	CCONJ
gs-3751	423	10	therapeutic	therapeutic	ADJ
gs-3751	423	11	implications	implication	NOUN
gs-3751	423	12	.	.	PUNCT
gs-3751	424	1	frontiers	frontier	NOUN
gs-3751	424	2	in	in	ADP
gs-3751	424	3	neuroscience	neuroscience	NOUN
gs-3751	424	4	.	.	PUNCT
gs-3751	425	1	11	11	NUM
gs-3751	425	2	.	.	X
gs-3751	426	1	pizzaro	pizzaro	NOUN
gs-3751	426	2	,	,	PUNCT
gs-3751	426	3	m.	m.	NOUN
gs-3751	426	4	,	,	PUNCT
gs-3751	426	5	&	&	CCONJ
gs-3751	426	6	santos	santos	PROPN
gs-3751	426	7	,	,	PUNCT
gs-3751	426	8	j.	j.	PROPN
gs-3751	426	9	(	(	PUNCT
gs-3751	426	10	2024	2024	NUM
gs-3751	426	11	)	)	PUNCT
gs-3751	426	12	.	.	PUNCT
gs-3751	427	1	integrating	integrate	VERB
gs-3751	427	2	gut	gut	NOUN
gs-3751	427	3	microbiota	microbiota	NOUN
gs-3751	427	4	into	into	ADP
gs-3751	427	5	neurodegenerative	neurodegenerative	ADJ
gs-3751	427	6	disease	disease	NOUN
gs-3751	427	7	management	management	NOUN
gs-3751	427	8	:	:	PUNCT
gs-3751	427	9	a	a	DET
gs-3751	427	10	systems	system	NOUN
gs-3751	427	11	biology	biology	NOUN
gs-3751	427	12	approach	approach	NOUN
gs-3751	427	13	.	.	PUNCT
gs-3751	428	1	bmc	bmc	NOUN
gs-3751	428	2	systems	system	NOUN
gs-3751	428	3	biology	biology	NOUN
gs-3751	428	4	,	,	PUNCT
gs-3751	428	5	18	18	NUM
gs-3751	428	6	,	,	PUNCT
gs-3751	428	7	article	article	NOUN
gs-3751	428	8	24	24	NUM
gs-3751	428	9	.	.	PUNCT
gs-3751	428	10	12	12	NUM
gs-3751	428	11	.	.	PUNCT
gs-3751	429	1	aphkhazava	aphkhazava	PROPN
gs-3751	429	2	,	,	PUNCT
gs-3751	429	3	d.	d.	PROPN
gs-3751	429	4	,	,	PUNCT
gs-3751	429	5	sulashvili	sulashvili	NOUN
gs-3751	429	6	,	,	PUNCT
gs-3751	429	7	n.	n.	NOUN
gs-3751	429	8	,	,	PUNCT
gs-3751	429	9	tupinashvili	tupinashvili	NOUN
gs-3751	429	10	,	,	PUNCT
gs-3751	429	11	t.	t.	PROPN
gs-3751	429	12	,	,	PUNCT
gs-3751	429	13	&	&	CCONJ
gs-3751	429	14	nozadze	nozadze	NOUN
gs-3751	429	15	,	,	PUNCT
gs-3751	429	16	m.	m.	NOUN
gs-3751	429	17	(	(	PUNCT
gs-3751	429	18	2024	2024	NUM
gs-3751	429	19	)	)	PUNCT
gs-3751	429	20	.	.	PUNCT
gs-3751	430	1	dynamic	dynamic	ADJ
gs-3751	430	2	cellular	cellular	ADJ
gs-3751	430	3	equilibrium	equilibrium	NOUN
gs-3751	430	4	theory	theory	NOUN
gs-3751	430	5	of	of	ADP
gs-3751	430	6	aging	aging	NOUN
gs-3751	430	7	:	:	PUNCT
gs-3751	430	8	integrating	integrate	VERB
gs-3751	430	9	maintenance	maintenance	NOUN
gs-3751	430	10	and	and	CCONJ
gs-3751	430	11	accumulation	accumulation	NOUN
gs-3751	430	12	in	in	ADP
gs-3751	430	13	the	the	DET
gs-3751	430	14	aging	age	VERB
gs-3751	430	15	process	process	NOUN
gs-3751	430	16	.	.	PUNCT
gs-3751	431	1	scientific	scientific	ADJ
gs-3751	431	2	journal	journal	NOUN
gs-3751	431	3	„	„	PUNCT
gs-3751	431	4	spectri	spectri	NOUN
gs-3751	431	5	“	"	PUNCT
gs-3751	431	6	,	,	PUNCT
gs-3751	431	7	8(2	8(2	NUM
gs-3751	431	8	)	)	PUNCT
gs-3751	431	9	.	.	PUNCT
gs-3751	432	1	https://doi.org/10.52340/spectri.2023.08.02.03	https://doi.org/10.52340/spectri.2023.08.02.03	ADJ
gs-3751	432	2	13	13	NUM
gs-3751	432	3	.	.	PUNCT
gs-3751	433	1	aphkhazava	aphkhazava	PROPN
gs-3751	433	2	,	,	PUNCT
gs-3751	433	3	d.	d.	PROPN
gs-3751	433	4	,	,	PUNCT
gs-3751	433	5	tuphinashvili	tuphinashvili	NOUN
gs-3751	433	6	,	,	PUNCT
gs-3751	433	7	t.	t.	NOUN
gs-3751	433	8	,	,	PUNCT
gs-3751	433	9	sulashvili	sulashvili	NOUN
gs-3751	433	10	,	,	PUNCT
gs-3751	433	11	n.	n.	NOUN
gs-3751	433	12	,	,	PUNCT
gs-3751	433	13	&	&	CCONJ
gs-3751	433	14	nozadze	nozadze	NOUN
gs-3751	433	15	,	,	PUNCT
gs-3751	433	16	m.	m.	NOUN
gs-3751	433	17	(	(	PUNCT
gs-3751	433	18	2023	2023	NUM
gs-3751	433	19	)	)	PUNCT
gs-3751	433	20	.	.	PUNCT
gs-3751	434	1	the	the	DET
gs-3751	434	2	features	feature	NOUN
gs-3751	434	3	and	and	CCONJ
gs-3751	434	4	role	role	NOUN
gs-3751	434	5	of	of	ADP
gs-3751	434	6	shp2	shp2	ADJ
gs-3751	434	7	protein	protein	NOUN
gs-3751	434	8	in	in	ADP
gs-3751	434	9	postnatal	postnatal	ADJ
gs-3751	434	10	muscle	muscle	NOUN
gs-3751	434	11	development	development	NOUN
gs-3751	434	12	.	.	PUNCT
gs-3751	435	1	scientific	scientific	ADJ
gs-3751	435	2	journal	journal	NOUN
gs-3751	435	3	„	„	PUNCT
gs-3751	435	4	spectri	spectri	NOUN
gs-3751	435	5	“	"	PUNCT
gs-3751	435	6	,	,	PUNCT
gs-3751	435	7	1	1	X
gs-3751	435	8	.	.	PUNCT
gs-3751	436	1	https://doi.org/10.52340/spectri.2023.01	https://doi.org/10.52340/spectri.2023.01	DET
gs-3751	436	2	14	14	NUM
gs-3751	436	3	.	.	PUNCT
gs-3751	437	1	sulashvili	sulashvili	NOUN
gs-3751	437	2	,	,	PUNCT
gs-3751	437	3	n.	n.	NOUN
gs-3751	437	4	,	,	PUNCT
gs-3751	437	5	beglaryan	beglaryan	ADJ
gs-3751	437	6	,	,	PUNCT
gs-3751	437	7	m.	m.	NOUN
gs-3751	437	8	,	,	PUNCT
gs-3751	437	9	gorgaslidze	gorgaslidze	PROPN
gs-3751	437	10	,	,	PUNCT
gs-3751	437	11	n.	n.	PROPN
gs-3751	437	12	,	,	PUNCT
gs-3751	437	13	kocharyan	kocharyan	PROPN
gs-3751	437	14	,	,	PUNCT
gs-3751	437	15	s.	s.	PROPN
gs-3751	437	16	,	,	PUNCT
gs-3751	437	17	chichoyan	chichoyan	PROPN
gs-3751	437	18	,	,	PUNCT
gs-3751	437	19	n.	n.	NOUN
gs-3751	437	20	,	,	PUNCT
gs-3751	437	21	gabunia	gabunia	NOUN
gs-3751	437	22	,	,	PUNCT
gs-3751	437	23	l.	l.	PROPN
gs-3751	437	24	,	,	PUNCT
gs-3751	437	25	…	…	PUNCT
gs-3751	437	26	zarnadze	zarnadze	PROPN
gs-3751	437	27	,	,	PUNCT
gs-3751	437	28	s.	s.	PROPN
gs-3751	437	29	(	(	PUNCT
gs-3751	437	30	davit	davit	PROPN
gs-3751	437	31	)	)	PUNCT
gs-3751	437	32	.	.	PUNCT
gs-3751	438	1	(	(	PUNCT
gs-3751	438	2	2023	2023	NUM
gs-3751	438	3	)	)	PUNCT
gs-3751	438	4	.	.	PUNCT
gs-3751	439	1	the	the	DET
gs-3751	439	2	disclosure	disclosure	NOUN
gs-3751	439	3	of	of	ADP
gs-3751	439	4	features	feature	NOUN
gs-3751	439	5	,	,	PUNCT
gs-3751	439	6	characteristics	characteristic	NOUN
gs-3751	439	7	,	,	PUNCT
gs-3751	439	8	possibilities	possibility	NOUN
gs-3751	439	9	and	and	CCONJ
gs-3751	439	10	specialties	specialty	NOUN
gs-3751	439	11	of	of	ADP
gs-3751	439	12	clinical	clinical	ADJ
gs-3751	439	13	pharmacists	pharmacist	NOUN
gs-3751	439	14	as	as	ADP
gs-3751	439	15	mediator	mediator	NOUN
gs-3751	439	16	among	among	ADP
gs-3751	439	17	doctors	doctor	NOUN
gs-3751	439	18	and	and	CCONJ
gs-3751	439	19	patients	patient	NOUN
gs-3751	439	20	for	for	ADP
gs-3751	439	21	enhancement	enhancement	NOUN
gs-3751	439	22	public	public	ADJ
gs-3751	439	23	health	health	NOUN
gs-3751	439	24	sector	sector	NOUN
gs-3751	439	25	in	in	ADP
gs-3751	439	26	a	a	DET
gs-3751	439	27	global	global	ADJ
gs-3751	439	28	world	world	NOUN
gs-3751	439	29	.	.	PUNCT
gs-3751	440	1	experimental	experimental	ADJ
gs-3751	440	2	and	and	CCONJ
gs-3751	440	3	clinical	clinical	ADJ
gs-3751	440	4	medicine	medicine	NOUN
gs-3751	440	5	georgia	georgia	PROPN
gs-3751	440	6	,	,	PUNCT
gs-3751	440	7	(	(	PUNCT
gs-3751	440	8	4	4	NUM
gs-3751	440	9	)	)	PUNCT
gs-3751	440	10	,	,	PUNCT
gs-3751	440	11	57–62	57–62	NUM
gs-3751	440	12	.	.	PUNCT
gs-3751	441	1	https://doi.org/10.52340/jecm.2023.04.15	https://doi.org/10.52340/jecm.2023.04.15	PROPN
gs-3751	441	2	15	15	NUM
gs-3751	441	3	.	.	PUNCT
gs-3751	441	4	sulashvili	sulashvili	NOUN
gs-3751	441	5	,	,	PUNCT
gs-3751	441	6	n.	n.	NOUN
gs-3751	441	7	,	,	PUNCT
gs-3751	441	8	gorgaslidze	gorgaslidze	PROPN
gs-3751	441	9	,	,	PUNCT
gs-3751	441	10	n.	n.	NOUN
gs-3751	441	11	,	,	PUNCT
gs-3751	441	12	gabunia	gabunia	NOUN
gs-3751	441	13	,	,	PUNCT
gs-3751	441	14	l.	l.	PROPN
gs-3751	441	15	,	,	PUNCT
gs-3751	441	16	giorgobiani	giorgobiani	PROPN
gs-3751	441	17	,	,	PUNCT
gs-3751	441	18	m.	m.	NOUN
gs-3751	441	19	,	,	PUNCT
gs-3751	441	20	&	&	CCONJ
gs-3751	441	21	ratiani	ratiani	PROPN
gs-3751	441	22	,	,	PUNCT
gs-3751	441	23	l.	l.	PROPN
gs-3751	441	24	(	(	PUNCT
gs-3751	441	25	2023	2023	NUM
gs-3751	441	26	)	)	PUNCT
gs-3751	441	27	.	.	PUNCT
gs-3751	442	1	manifestation	manifestation	NOUN
gs-3751	442	2	of	of	ADP
gs-3751	442	3	the	the	DET
gs-3751	442	4	particularities	particularity	NOUN
gs-3751	442	5	of	of	ADP
gs-3751	442	6	the	the	DET
gs-3751	442	7	usage	usage	NOUN
gs-3751	442	8	features	feature	NOUN
gs-3751	442	9	of	of	ADP
gs-3751	442	10	monoclonal	monoclonal	NOUN
gs-3751	442	11	antibodies	antibody	NOUN
gs-3751	442	12	in	in	ADP
gs-3751	442	13	various	various	ADJ
gs-3751	442	14	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-3751	442	15	applications	application	NOUN
gs-3751	442	16	.	.	PUNCT
gs-3751	443	1	experimental	experimental	ADJ
gs-3751	443	2	and	and	CCONJ
gs-3751	443	3	clinical	clinical	ADJ
gs-3751	443	4	medicine	medicine	NOUN
gs-3751	443	5	georgia	georgia	PROPN
gs-3751	443	6	,	,	PUNCT
gs-3751	443	7	(	(	PUNCT
gs-3751	443	8	4	4	NUM
gs-3751	443	9	)	)	PUNCT
gs-3751	443	10	,	,	PUNCT
gs-3751	443	11	52–57	52–57	NUM
gs-3751	443	12	.	.	PUNCT
gs-3751	444	1	georgian	georgian	ADJ
gs-3751	444	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3751	444	3	მეცნიერები	მეცნიერები	NOUN
gs-3751	444	4	ტ.	ტ.	VERB
gs-3751	444	5	7	7	NUM
gs-3751	444	6	n	n	DET
gs-3751	444	7	2	2	NUM
gs-3751	444	8	,	,	PUNCT
gs-3751	444	9	2025	2025	NUM
gs-3751	444	10	352	352	NUM
gs-3751	444	11	16	16	NUM
gs-3751	444	12	.	.	PUNCT
gs-3751	445	1	sulashvili	sulashvili	NOUN
gs-3751	445	2	,	,	PUNCT
gs-3751	445	3	n.	n.	NOUN
gs-3751	445	4	,	,	PUNCT
gs-3751	445	5	davitashvili	davitashvili	ADJ
gs-3751	445	6	,	,	PUNCT
gs-3751	445	7	m.	m.	NOUN
gs-3751	445	8	,	,	PUNCT
gs-3751	445	9	gorgaslidze	gorgaslidze	PROPN
gs-3751	445	10	,	,	PUNCT
gs-3751	445	11	n.	n.	NOUN
gs-3751	445	12	,	,	PUNCT
gs-3751	445	13	gabunia	gabunia	NOUN
gs-3751	445	14	,	,	PUNCT
gs-3751	445	15	l.	l.	PROPN
gs-3751	445	16	,	,	PUNCT
gs-3751	445	17	beglaryan	beglaryan	ADJ
gs-3751	445	18	,	,	PUNCT
gs-3751	445	19	m.	m.	NOUN
gs-3751	445	20	,	,	PUNCT
gs-3751	445	21	alavidze	alavidze	NOUN
gs-3751	445	22	,	,	PUNCT
gs-3751	445	23	n.	n.	NOUN
gs-3751	445	24	,	,	PUNCT
gs-3751	445	25	…	…	PUNCT
gs-3751	445	26	sulashvili	sulashvili	NOUN
gs-3751	445	27	,	,	PUNCT
gs-3751	445	28	m.	m.	NOUN
gs-3751	445	29	(	(	PUNCT
gs-3751	445	30	2024	2024	NUM
gs-3751	445	31	)	)	PUNCT
gs-3751	445	32	.	.	PUNCT
gs-3751	446	1	the	the	DET
gs-3751	446	2	scientific	scientific	ADJ
gs-3751	446	3	discussion	discussion	NOUN
gs-3751	446	4	of	of	ADP
gs-3751	446	5	some	some	DET
gs-3751	446	6	issues	issue	NOUN
gs-3751	446	7	of	of	ADP
gs-3751	446	8	features	feature	NOUN
gs-3751	446	9	and	and	CCONJ
gs-3751	446	10	challenges	challenge	NOUN
gs-3751	446	11	of	of	ADP
gs-3751	446	12	using	use	VERB
gs-3751	446	13	of	of	ADP
gs-3751	446	14	car	car	NOUN
gs-3751	446	15	-	-	PUNCT
gs-3751	446	16	t	t	NOUN
gs-3751	446	17	cells	cell	NOUN
gs-3751	446	18	in	in	ADP
gs-3751	446	19	immunotherapy	immunotherapy	NOUN
gs-3751	446	20	.	.	PUNCT
gs-3751	447	1	georgian	georgian	ADJ
gs-3751	447	2	scientists	scientist	NOUN
gs-3751	447	3	,	,	PUNCT
gs-3751	447	4	6(4	6(4	NOUN
gs-3751	447	5	)	)	PUNCT
gs-3751	447	6	,	,	PUNCT
gs-3751	447	7	263–290	263–290	NUM
gs-3751	447	8	.	.	PUNCT
gs-3751	447	9	https://doi.org/10.52340/gs.2024.06.04.24	https://doi.org/10.52340/gs.2024.06.04.24	PROPN
gs-3751	447	10	17	17	NUM
gs-3751	447	11	.	.	PUNCT
gs-3751	448	1	sulashvili	sulashvili	NOUN
gs-3751	448	2	,	,	PUNCT
gs-3751	448	3	n.	n.	NOUN
gs-3751	448	4	,	,	PUNCT
gs-3751	448	5	gorgaslidze	gorgaslidze	PROPN
gs-3751	448	6	,	,	PUNCT
gs-3751	448	7	n.	n.	NOUN
gs-3751	448	8	,	,	PUNCT
gs-3751	448	9	gabunia	gabunia	NOUN
gs-3751	448	10	,	,	PUNCT
gs-3751	448	11	l.	l.	PROPN
gs-3751	448	12	,	,	PUNCT
gs-3751	448	13	giorgobiani	giorgobiani	PROPN
gs-3751	448	14	,	,	PUNCT
gs-3751	448	15	m.	m.	NOUN
gs-3751	448	16	,	,	PUNCT
gs-3751	448	17	&	&	CCONJ
gs-3751	448	18	ratiani	ratiani	PROPN
gs-3751	448	19	,	,	PUNCT
gs-3751	448	20	l.	l.	PROPN
gs-3751	448	21	(	(	PUNCT
gs-3751	448	22	2023	2023	NUM
gs-3751	448	23	)	)	PUNCT
gs-3751	448	24	.	.	PUNCT
gs-3751	449	1	manifestation	manifestation	NOUN
gs-3751	449	2	of	of	ADP
gs-3751	449	3	the	the	DET
gs-3751	449	4	particularities	particularity	NOUN
gs-3751	449	5	of	of	ADP
gs-3751	449	6	the	the	DET
gs-3751	449	7	usage	usage	NOUN
gs-3751	449	8	features	feature	NOUN
gs-3751	449	9	of	of	ADP
gs-3751	449	10	monoclonal	monoclonal	NOUN
gs-3751	449	11	antibodies	antibody	NOUN
gs-3751	449	12	in	in	ADP
gs-3751	449	13	various	various	ADJ
gs-3751	449	14	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-3751	449	15	applications	application	NOUN
gs-3751	449	16	.	.	PUNCT
gs-3751	450	1	experimental	experimental	ADJ
gs-3751	450	2	and	and	CCONJ
gs-3751	450	3	clinical	clinical	ADJ
gs-3751	450	4	medicine	medicine	NOUN
gs-3751	450	5	georgia	georgia	PROPN
gs-3751	450	6	,	,	PUNCT
gs-3751	450	7	(	(	PUNCT
gs-3751	450	8	4	4	NUM
gs-3751	450	9	)	)	PUNCT
gs-3751	450	10	,	,	PUNCT
gs-3751	450	11	52–57	52–57	NUM
gs-3751	450	12	.	.	PUNCT
gs-3751	451	1	https://doi.org/10.52340/jecm.2023.04.14	https://doi.org/10.52340/jecm.2023.04.14	X
gs-3751	452	1	18	18	NUM
gs-3751	452	2	.	.	PUNCT
gs-3751	452	3	sulashvili	sulashvili	NOUN
gs-3751	452	4	,	,	PUNCT
gs-3751	452	5	n.	n.	NOUN
gs-3751	452	6	,	,	PUNCT
gs-3751	452	7	gorgaslidze	gorgaslidze	PROPN
gs-3751	452	8	,	,	PUNCT
gs-3751	452	9	n.	n.	NOUN
gs-3751	452	10	,	,	PUNCT
gs-3751	452	11	gabunia	gabunia	NOUN
gs-3751	452	12	,	,	PUNCT
gs-3751	452	13	l.	l.	PROPN
gs-3751	452	14	,	,	PUNCT
gs-3751	452	15	ratiani	ratiani	PROPN
gs-3751	452	16	,	,	PUNCT
gs-3751	452	17	l.	l.	PROPN
gs-3751	452	18	,	,	PUNCT
gs-3751	452	19	khetsuriani	khetsuriani	PROPN
gs-3751	452	20	,	,	PUNCT
gs-3751	452	21	s.	s.	PROPN
gs-3751	452	22	,	,	PUNCT
gs-3751	452	23	kravchenko	kravchenko	PROPN
gs-3751	452	24	,	,	PUNCT
gs-3751	452	25	v.	v.	NOUN
gs-3751	452	26	,	,	PUNCT
gs-3751	452	27	sulashvili	sulashvili	NOUN
gs-3751	452	28	,	,	PUNCT
gs-3751	452	29	m.	m.	NOUN
gs-3751	452	30	(	(	PUNCT
gs-3751	452	31	2024	2024	NUM
gs-3751	452	32	)	)	PUNCT
gs-3751	452	33	.	.	PUNCT
gs-3751	453	1	manifestation	manifestation	NOUN
gs-3751	453	2	of	of	ADP
gs-3751	453	3	the	the	DET
gs-3751	453	4	particularities	particularity	NOUN
gs-3751	453	5	of	of	ADP
gs-3751	453	6	some	some	DET
gs-3751	453	7	key	key	ADJ
gs-3751	453	8	issue	issue	NOUN
gs-3751	453	9	aspects	aspect	NOUN
gs-3751	453	10	of	of	ADP
gs-3751	453	11	new	new	ADJ
gs-3751	453	12	immunotherapy	immunotherapy	NOUN
gs-3751	453	13	challenges	challenge	NOUN
gs-3751	453	14	and	and	CCONJ
gs-3751	453	15	perspectives	perspective	NOUN
gs-3751	453	16	by	by	ADP
gs-3751	453	17	car	car	NOUN
gs-3751	453	18	-	-	PUNCT
gs-3751	453	19	t	t	NOUN
gs-3751	453	20	cell	cell	NOUN
gs-3751	453	21	therapy	therapy	NOUN
gs-3751	453	22	.	.	PUNCT
gs-3751	454	1	experimental	experimental	ADJ
gs-3751	454	2	and	and	CCONJ
gs-3751	454	3	clinical	clinical	ADJ
gs-3751	454	4	medicine	medicine	NOUN
gs-3751	454	5	georgia	georgia	PROPN
gs-3751	454	6	,	,	PUNCT
gs-3751	454	7	(	(	PUNCT
gs-3751	454	8	4	4	NUM
gs-3751	454	9	)	)	PUNCT
gs-3751	454	10	,	,	PUNCT
gs-3751	454	11	119–121	119–121	NUM
gs-3751	454	12	.	.	PUNCT
gs-3751	454	13	https://doi.org/10.52340/jecm.2024.04.32	https://doi.org/10.52340/jecm.2024.04.32	NUM
gs-3751	454	14	.	.	NOUN
gs-3751	454	15	19	19	NUM
gs-3751	454	16	.	.	X
gs-3751	455	1	swain	swain	PROPN
gs-3751	455	2	,	,	PUNCT
gs-3751	455	3	n.	n.	PROPN
gs-3751	455	4	,	,	PUNCT
gs-3751	455	5	thakur	thakur	PROPN
gs-3751	455	6	,	,	PUNCT
gs-3751	455	7	m.	m.	NOUN
gs-3751	455	8	,	,	PUNCT
gs-3751	455	9	pathak	pathak	PROPN
gs-3751	455	10	,	,	PUNCT
gs-3751	455	11	j.	j.	PROPN
gs-3751	455	12	,	,	PUNCT
gs-3751	455	13	&	&	CCONJ
gs-3751	455	14	swain	swain	PROPN
gs-3751	455	15	,	,	PUNCT
gs-3751	455	16	b.	b.	PROPN
gs-3751	455	17	(	(	PUNCT
gs-3751	455	18	2020	2020	NUM
gs-3751	455	19	)	)	PUNCT
gs-3751	455	20	.	.	PUNCT
gs-3751	456	1	sox2	sox2	NOUN
gs-3751	456	2	,	,	PUNCT
gs-3751	456	3	oct4	oct4	PROPN
gs-3751	456	4	and	and	CCONJ
gs-3751	456	5	nanog	nanog	PROPN
gs-3751	456	6	:	:	PUNCT
gs-3751	456	7	the	the	DET
gs-3751	456	8	core	core	ADJ
gs-3751	456	9	embryonic	embryonic	ADJ
gs-3751	456	10	stem	stem	NOUN
gs-3751	456	11	cell	cell	NOUN
gs-3751	456	12	pluripotency	pluripotency	NOUN
gs-3751	456	13	regulators	regulator	NOUN
gs-3751	456	14	in	in	ADP
gs-3751	456	15	oral	oral	ADJ
gs-3751	456	16	carcinogenesis	carcinogenesis	NOUN
gs-3751	456	17	.	.	PUNCT
gs-3751	457	1	journal	journal	NOUN
gs-3751	457	2	of	of	ADP
gs-3751	457	3	oral	oral	ADJ
gs-3751	457	4	and	and	CCONJ
gs-3751	457	5	maxillofacial	maxillofacial	ADJ
gs-3751	457	6	pathology	pathology	NOUN
gs-3751	457	7	,	,	PUNCT
gs-3751	457	8	24(2	24(2	NUM
gs-3751	457	9	)	)	PUNCT
gs-3751	457	10	,	,	PUNCT
gs-3751	457	11	368–373	368–373	NUM
gs-3751	457	12	.	.	NOUN
gs-3751	457	13	https://doi.org/10.4103/jomfp.jomfp_84_20	https://doi.org/10.4103/jomfp.jomfp_84_20	PROPN
gs-3751	457	14	20	20	NUM
gs-3751	457	15	.	.	PUNCT
gs-3751	457	16	sulashvili	sulashvili	NOUN
gs-3751	457	17	,	,	PUNCT
gs-3751	457	18	n.	n.	NOUN
gs-3751	457	19	.	.	PUNCT
gs-3751	458	1	.	.	PUNCT
gs-3751	458	2	,	,	PUNCT
gs-3751	459	1	gorgaslidze	gorgaslidze	INTJ
gs-3751	459	2	,	,	PUNCT
gs-3751	459	3	n.	n.	PROPN
gs-3751	459	4	.	.	PUNCT
gs-3751	460	1	,	,	PUNCT
gs-3751	460	2	beglaryan	beglaryan	ADJ
gs-3751	460	3	,	,	PUNCT
gs-3751	460	4	m.	m.	NOUN
gs-3751	460	5	.	.	PUNCT
gs-3751	460	6	,	,	PUNCT
gs-3751	460	7	gabunia	gabunia	NOUN
gs-3751	460	8	,	,	PUNCT
gs-3751	460	9	l.	l.	PROPN
gs-3751	460	10	.	.	PROPN
gs-3751	460	11	,	,	PUNCT
gs-3751	460	12	chichoyan	chichoyan	PROPN
gs-3751	460	13	,	,	PUNCT
gs-3751	460	14	n.	n.	PROPN
gs-3751	460	15	.	.	PUNCT
gs-3751	460	16	,	,	PUNCT
gs-3751	460	17	giorgobiani	giorgobiani	PROPN
gs-3751	460	18	,	,	PUNCT
gs-3751	460	19	m.	m.	NOUN
gs-3751	460	20	.	.	PUNCT
gs-3751	461	1	,	,	PUNCT
gs-3751	461	2	…	…	PUNCT
gs-3751	461	3	zarnadze	zarnadze	INTJ
gs-3751	461	4	,	,	PUNCT
gs-3751	461	5	s.	s.	PROPN
gs-3751	461	6	(	(	PUNCT
gs-3751	461	7	davit	davit	PROPN
gs-3751	461	8	)	)	PUNCT
gs-3751	461	9	.	.	PUNCT
gs-3751	462	1	(	(	PUNCT
gs-3751	462	2	2022	2022	NUM
gs-3751	462	3	)	)	PUNCT
gs-3751	462	4	.	.	PUNCT
gs-3751	463	1	the	the	DET
gs-3751	463	2	scientific	scientific	ADJ
gs-3751	463	3	talks	talk	NOUN
gs-3751	463	4	of	of	ADP
gs-3751	463	5	essential	essential	ADJ
gs-3751	463	6	issue	issue	NOUN
gs-3751	463	7	,	,	PUNCT
gs-3751	463	8	invocation	invocation	NOUN
gs-3751	463	9	,	,	PUNCT
gs-3751	463	10	perspectives	perspective	NOUN
gs-3751	463	11	,	,	PUNCT
gs-3751	463	12	inclinations	inclination	NOUN
gs-3751	463	13	and	and	CCONJ
gs-3751	463	14	features	feature	NOUN
gs-3751	463	15	of	of	ADP
gs-3751	463	16	the	the	DET
gs-3751	463	17	clinical	clinical	ADJ
gs-3751	463	18	pharmacists	pharmacist	NOUN
gs-3751	463	19	globally	globally	ADV
gs-3751	463	20	.	.	PUNCT
gs-3751	464	1	experimental	experimental	ADJ
gs-3751	464	2	and	and	CCONJ
gs-3751	464	3	clinical	clinical	ADJ
gs-3751	464	4	medicine	medicine	NOUN
gs-3751	464	5	georgia	georgia	PROPN
gs-3751	464	6	,	,	PUNCT
gs-3751	464	7	(	(	PUNCT
gs-3751	464	8	7	7	NUM
gs-3751	464	9	)	)	PUNCT
gs-3751	464	10	.	.	PUNCT
gs-3751	465	1	21	21	NUM
gs-3751	465	2	.	.	X
gs-3751	466	1	zhang	zhang	PROPN
gs-3751	466	2	,	,	PUNCT
gs-3751	466	3	x.	x.	PROPN
gs-3751	466	4	,	,	PUNCT
gs-3751	466	5	&	&	CCONJ
gs-3751	466	6	li	li	PROPN
gs-3751	466	7	,	,	PUNCT
gs-3751	466	8	y.	y.	PROPN
gs-3751	466	9	(	(	PUNCT
gs-3751	466	10	2024	2024	NUM
gs-3751	466	11	)	)	PUNCT
gs-3751	466	12	.	.	PUNCT
gs-3751	467	1	microbiota	microbiota	NOUN
gs-3751	467	2	–	–	PUNCT
gs-3751	467	3	gut	gut	NOUN
gs-3751	467	4	–	–	PUNCT
gs-3751	467	5	brain	brain	NOUN
gs-3751	467	6	axis	axis	NOUN
gs-3751	467	7	and	and	CCONJ
gs-3751	467	8	its	its	PRON
gs-3751	467	9	therapeutic	therapeutic	ADJ
gs-3751	467	10	applications	application	NOUN
gs-3751	467	11	in	in	ADP
gs-3751	467	12	neurodegenerative	neurodegenerative	ADJ
gs-3751	467	13	disorders	disorder	NOUN
gs-3751	467	14	.	.	PUNCT
gs-3751	468	1	signal	signal	ADJ
gs-3751	468	2	transduction	transduction	NOUN
gs-3751	468	3	and	and	CCONJ
gs-3751	468	4	targeted	target	VERB
gs-3751	468	5	therapy	therapy	NOUN
gs-3751	468	6	.	.	PUNCT
gs-3751	469	1	22	22	NUM
gs-3751	469	2	.	.	PUNCT
gs-3751	470	1	liu	liu	PROPN
gs-3751	470	2	,	,	PUNCT
gs-3751	470	3	k.	k.	PROPN
gs-3751	470	4	,	,	PUNCT
gs-3751	470	5	&	&	CCONJ
gs-3751	470	6	li	li	PROPN
gs-3751	470	7	,	,	PUNCT
gs-3751	470	8	j.	j.	PROPN
gs-3751	470	9	(	(	PUNCT
gs-3751	470	10	2023	2023	NUM
gs-3751	470	11	)	)	PUNCT
gs-3751	470	12	.	.	PUNCT
gs-3751	471	1	probiotics	probiotic	NOUN
gs-3751	471	2	and	and	CCONJ
gs-3751	471	3	fecal	fecal	ADJ
gs-3751	471	4	microbiota	microbiota	NOUN
gs-3751	471	5	transplantation	transplantation	NOUN
gs-3751	471	6	in	in	ADP
gs-3751	471	7	parkinson	parkinson	NOUN
gs-3751	471	8	’s	’s	PART
gs-3751	471	9	disease	disease	NOUN
gs-3751	471	10	:	:	PUNCT
gs-3751	471	11	current	current	ADJ
gs-3751	471	12	evidence	evidence	NOUN
gs-3751	471	13	and	and	CCONJ
gs-3751	471	14	future	future	ADJ
gs-3751	471	15	perspectives	perspective	NOUN
gs-3751	471	16	.	.	PUNCT
gs-3751	472	1	clinical	clinical	ADJ
gs-3751	472	2	neurology	neurology	NOUN
gs-3751	472	3	and	and	CCONJ
gs-3751	472	4	neurosurgery	neurosurgery	NOUN
gs-3751	472	5	,	,	PUNCT
gs-3751	472	6	228	228	NUM
gs-3751	472	7	,	,	PUNCT
gs-3751	472	8	107645	107645	NUM
gs-3751	472	9	.	.	PUNCT
gs-3751	473	1	23	23	NUM
gs-3751	473	2	.	.	X
gs-3751	474	1	patel	patel	PROPN
gs-3751	474	2	,	,	PUNCT
gs-3751	474	3	a.	a.	PROPN
gs-3751	474	4	,	,	PUNCT
gs-3751	474	5	&	&	CCONJ
gs-3751	474	6	kumar	kumar	PROPN
gs-3751	474	7	,	,	PUNCT
gs-3751	474	8	s.	s.	PROPN
gs-3751	474	9	(	(	PUNCT
gs-3751	474	10	2024	2024	NUM
gs-3751	474	11	)	)	PUNCT
gs-3751	474	12	.	.	PUNCT
gs-3751	475	1	diet	diet	NOUN
gs-3751	475	2	,	,	PUNCT
gs-3751	475	3	gut	gut	NOUN
gs-3751	475	4	microbiome	microbiome	NOUN
gs-3751	475	5	,	,	PUNCT
gs-3751	475	6	and	and	CCONJ
gs-3751	475	7	neurodegeneration	neurodegeneration	NOUN
gs-3751	475	8	:	:	PUNCT
gs-3751	475	9	a	a	DET
gs-3751	475	10	comprehensive	comprehensive	ADJ
gs-3751	475	11	review	review	NOUN
gs-3751	475	12	.	.	PUNCT
gs-3751	476	1	nutrients	nutrient	NOUN
gs-3751	476	2	,	,	PUNCT
gs-3751	476	3	16(3	16(3	NOUN
gs-3751	476	4	)	)	PUNCT
gs-3751	476	5	,	,	PUNCT
gs-3751	476	6	456	456	NUM
gs-3751	476	7	.	.	PUNCT
gs-3751	477	1	24	24	NUM
gs-3751	477	2	.	.	PUNCT
gs-3751	478	1	sulashvili	sulashvili	PROPN
gs-3751	478	2	n	n	CCONJ
gs-3751	478	3	,	,	PUNCT
gs-3751	478	4	nimangre	nimangre	PROPN
gs-3751	478	5	rr	rr	PROPN
gs-3751	478	6	.	.	PUNCT
gs-3751	479	1	manifestation	manifestation	NOUN
gs-3751	479	2	of	of	ADP
gs-3751	479	3	some	some	DET
gs-3751	479	4	aspects	aspect	NOUN
gs-3751	479	5	of	of	ADP
gs-3751	479	6	cardiovascular	cardiovascular	ADJ
gs-3751	479	7	diseases	disease	NOUN
gs-3751	479	8	,	,	PUNCT
gs-3751	479	9	implications	implication	NOUN
gs-3751	479	10	,	,	PUNCT
gs-3751	479	11	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-3751	479	12	strategies	strategy	NOUN
gs-3751	479	13	,	,	PUNCT
gs-3751	479	14	effects	effect	NOUN
gs-3751	479	15	,	,	PUNCT
gs-3751	479	16	impacts	impact	NOUN
gs-3751	479	17	and	and	CCONJ
gs-3751	479	18	potential	potential	ADJ
gs-3751	479	19	hazards	hazard	NOUN
gs-3751	479	20	in	in	ADP
gs-3751	479	21	general	general	ADJ
gs-3751	479	22	.	.	PUNCT
gs-3751	480	1	jr	jr	PROPN
gs-3751	481	1	[	[	X
gs-3751	481	2	internet	internet	NOUN
gs-3751	481	3	]	]	PUNCT
gs-3751	481	4	.	.	PUNCT
gs-3751	482	1	2025	2025	NUM
gs-3751	482	2	feb	feb	X
gs-3751	482	3	.	.	PROPN
gs-3751	482	4	7	7	NUM
gs-3751	482	5	[	[	X
gs-3751	482	6	cited	cite	VERB
gs-3751	482	7	2025	2025	NUM
gs-3751	482	8	may	may	PROPN
gs-3751	482	9	22];3(1):1	22];3(1):1	NUM
gs-3751	482	10	-	-	SYM
gs-3751	482	11	27	27	NUM
gs-3751	482	12	.	.	PUNCT
gs-3751	483	1	available	available	ADJ
gs-3751	483	2	from	from	ADP
gs-3751	483	3	:	:	PUNCT
gs-3751	483	4	https://journals.4science.ge/index.php/jr/article/view/3393	https://journals.4science.ge/index.php/jr/article/view/3393	PROPN
gs-3751	483	5	.	.	PUNCT
gs-3751	484	1	25	25	NUM
gs-3751	484	2	.	.	PUNCT
gs-3751	485	1	ochoa	ochoa	NOUN
gs-3751	485	2	-	-	PUNCT
gs-3751	485	3	repáraz	repáraz	PROPN
gs-3751	485	4	,	,	PUNCT
gs-3751	485	5	j.	j.	PROPN
gs-3751	485	6	,	,	PUNCT
gs-3751	485	7	&	&	CCONJ
gs-3751	485	8	kasper	kasper	PROPN
gs-3751	485	9	,	,	PUNCT
gs-3751	485	10	l.	l.	PROPN
gs-3751	485	11	h.	h.	PROPN
gs-3751	485	12	(	(	PUNCT
gs-3751	485	13	2023	2023	NUM
gs-3751	485	14	)	)	PUNCT
gs-3751	485	15	.	.	PUNCT
gs-3751	486	1	the	the	DET
gs-3751	486	2	second	second	ADJ
gs-3751	486	3	brain	brain	NOUN
gs-3751	486	4	:	:	PUNCT
gs-3751	486	5	the	the	DET
gs-3751	486	6	role	role	NOUN
gs-3751	486	7	of	of	ADP
gs-3751	486	8	gut	gut	NOUN
gs-3751	486	9	microbiota	microbiota	NOUN
gs-3751	486	10	in	in	ADP
gs-3751	486	11	neurodegeneration	neurodegeneration	NOUN
gs-3751	486	12	.	.	PUNCT
gs-3751	487	1	brain	brain	NOUN
gs-3751	487	2	,	,	PUNCT
gs-3751	487	3	behavior	behavior	NOUN
gs-3751	487	4	,	,	PUNCT
gs-3751	487	5	and	and	CCONJ
gs-3751	487	6	immunity	immunity	NOUN
gs-3751	487	7	,	,	PUNCT
gs-3751	487	8	113	113	NUM
gs-3751	487	9	,	,	PUNCT
gs-3751	487	10	455–467	455–467	NUM
gs-3751	487	11	.	.	NOUN
gs-3751	487	12	26	26	NUM
gs-3751	487	13	.	.	PUNCT
gs-3751	488	1	gao	gao	PROPN
gs-3751	488	2	,	,	PUNCT
gs-3751	488	3	x.	x.	PROPN
gs-3751	488	4	,	,	PUNCT
gs-3751	488	5	wang	wang	PROPN
gs-3751	488	6	,	,	PUNCT
gs-3751	488	7	y.	y.	PROPN
gs-3751	488	8	,	,	PUNCT
gs-3751	488	9	&	&	CCONJ
gs-3751	488	10	xu	xu	PROPN
gs-3751	488	11	,	,	PUNCT
gs-3751	488	12	c.	c.	PROPN
gs-3751	488	13	(	(	PUNCT
gs-3751	488	14	2024	2024	NUM
gs-3751	488	15	)	)	PUNCT
gs-3751	488	16	.	.	PUNCT
gs-3751	489	1	gut	gut	VERB
gs-3751	489	2	microbiota	microbiota	NOUN
gs-3751	489	3	dysbiosis	dysbiosis	NOUN
gs-3751	489	4	and	and	CCONJ
gs-3751	489	5	its	its	PRON
gs-3751	489	6	clinical	clinical	ADJ
gs-3751	489	7	implications	implication	NOUN
gs-3751	489	8	in	in	ADP
gs-3751	489	9	alzheimer	alzheimer	PROPN
gs-3751	489	10	’s	’s	PART
gs-3751	489	11	disease	disease	NOUN
gs-3751	489	12	.	.	PUNCT
gs-3751	490	1	journal	journal	PROPN
gs-3751	490	2	of	of	ADP
gs-3751	490	3	alzheimer	alzheimer	PROPN
gs-3751	490	4	’s	’s	PART
gs-3751	490	5	disease	disease	NOUN
gs-3751	490	6	,	,	PUNCT
gs-3751	490	7	90(1	90(1	NUM
gs-3751	490	8	)	)	PUNCT
gs-3751	490	9	,	,	PUNCT
gs-3751	490	10	159–172	159–172	NUM
gs-3751	490	11	.	.	PUNCT
gs-3751	491	1	27	27	NUM
gs-3751	491	2	.	.	PUNCT
gs-3751	492	1	sulashvili	sulashvili	PROPN
gs-3751	492	2	n	n	CCONJ
gs-3751	492	3	,	,	PUNCT
gs-3751	492	4	yaduvanshi	yaduvanshi	NOUN
gs-3751	492	5	u	u	NOUN
gs-3751	492	6	,	,	PUNCT
gs-3751	492	7	yadav	yadav	PROPN
gs-3751	492	8	m	m	PROPN
gs-3751	492	9	,	,	PUNCT
gs-3751	492	10	gabunia	gabunia	NOUN
gs-3751	492	11	l	l	NOUN
gs-3751	492	12	,	,	PUNCT
gs-3751	492	13	ghambashidze	ghambashidze	PROPN
gs-3751	492	14	k	k	PROPN
gs-3751	492	15	,	,	PUNCT
gs-3751	492	16	gorgaslidze	gorgaslidze	ADJ
gs-3751	492	17	n	n	CCONJ
gs-3751	492	18	,	,	PUNCT
gs-3751	492	19	et	et	PROPN
gs-3751	492	20	al	al	PROPN
gs-3751	492	21	.	.	PUNCT
gs-3751	493	1	the	the	DET
gs-3751	493	2	scientific	scientific	ADJ
gs-3751	493	3	discourse	discourse	NOUN
gs-3751	493	4	of	of	ADP
gs-3751	493	5	features	feature	NOUN
gs-3751	493	6	of	of	ADP
gs-3751	493	7	clinical	clinical	ADJ
gs-3751	493	8	use	use	NOUN
gs-3751	493	9	and	and	CCONJ
gs-3751	493	10	pharmacology	pharmacology	NOUN
gs-3751	493	11	of	of	ADP
gs-3751	493	12	vasoconstrictors	vasoconstrictor	NOUN
gs-3751	493	13	and	and	CCONJ
gs-3751	493	14	their	their	PRON
gs-3751	493	15	impact	impact	NOUN
gs-3751	493	16	on	on	ADP
gs-3751	493	17	cardiac	cardiac	ADJ
gs-3751	493	18	function	function	NOUN
gs-3751	493	19	.	.	PUNCT
gs-3751	494	1	jr	jr	PROPN
gs-3751	495	1	[	[	X
gs-3751	495	2	internet	internet	NOUN
gs-3751	495	3	]	]	PUNCT
gs-3751	495	4	.	.	PUNCT
gs-3751	496	1	2025	2025	NUM
gs-3751	496	2	feb	feb	X
gs-3751	496	3	.	.	PROPN
gs-3751	496	4	21	21	NUM
gs-3751	496	5	[	[	X
gs-3751	496	6	cited	cite	VERB
gs-3751	496	7	2025	2025	NUM
gs-3751	496	8	may	may	PROPN
gs-3751	496	9	22];3(1):28	22];3(1):28	NUM
gs-3751	496	10	-	-	SYM
gs-3751	496	11	6	6	NUM
gs-3751	496	12	.	.	PUNCT
gs-3751	497	1	available	available	ADJ
gs-3751	497	2	from	from	ADP
gs-3751	497	3	:	:	PUNCT
gs-3751	497	4	https://journals.4science.ge/index.php/jr/article/view/3414	https://journals.4science.ge/index.php/jr/article/view/3414	PROPN
gs-3751	497	5	.	.	PUNCT
gs-3751	498	1	28	28	NUM
gs-3751	498	2	.	.	PUNCT
gs-3751	499	1	dutta	dutta	PROPN
gs-3751	499	2	,	,	PUNCT
gs-3751	499	3	a.	a.	PROPN
gs-3751	499	4	,	,	PUNCT
gs-3751	499	5	&	&	CCONJ
gs-3751	499	6	roy	roy	PROPN
gs-3751	499	7	,	,	PUNCT
gs-3751	499	8	s.	s.	PROPN
gs-3751	499	9	(	(	PUNCT
gs-3751	499	10	2024	2024	NUM
gs-3751	499	11	)	)	PUNCT
gs-3751	499	12	.	.	PUNCT
gs-3751	500	1	fecal	fecal	ADJ
gs-3751	500	2	microbiota	microbiota	NOUN
gs-3751	500	3	transplantation	transplantation	NOUN
gs-3751	500	4	in	in	ADP
gs-3751	500	5	neurodegenerative	neurodegenerative	ADJ
gs-3751	500	6	diseases	disease	NOUN
gs-3751	500	7	:	:	PUNCT
gs-3751	500	8	a	a	DET
gs-3751	500	9	narrative	narrative	NOUN
gs-3751	500	10	review	review	NOUN
gs-3751	500	11	.	.	PUNCT
gs-3751	501	1	frontiers	frontier	NOUN
gs-3751	501	2	in	in	ADP
gs-3751	501	3	cellular	cellular	ADJ
gs-3751	501	4	neuroscience	neuroscience	NOUN
gs-3751	501	5	,	,	PUNCT
gs-3751	501	6	18	18	NUM
gs-3751	501	7	,	,	PUNCT
gs-3751	501	8	article	article	NOUN
gs-3751	501	9	108451	108451	NUM
gs-3751	501	10	.	.	PUNCT
gs-3751	502	1	georgian	georgian	ADJ
gs-3751	502	2	scientists/ქართველი	scientists/ქართველი	PROPN
gs-3751	502	3	მეცნიერები	მეცნიერები	NOUN
gs-3751	502	4	ტ.	ტ.	VERB
gs-3751	502	5	7	7	NUM
gs-3751	502	6	n	n	DET
gs-3751	502	7	2	2	NUM
gs-3751	502	8	,	,	PUNCT
gs-3751	502	9	2025	2025	NUM
gs-3751	502	10	353	353	NUM
gs-3751	502	11	29	29	NUM
gs-3751	502	12	.	.	PUNCT
gs-3751	503	1	medina	medina	PROPN
gs-3751	503	2	,	,	PUNCT
gs-3751	503	3	d.	d.	PROPN
gs-3751	503	4	a.	a.	PROPN
gs-3751	503	5	,	,	PUNCT
gs-3751	503	6	&	&	CCONJ
gs-3751	503	7	mendez	mendez	PROPN
gs-3751	503	8	,	,	PUNCT
gs-3751	503	9	c.	c.	PROPN
gs-3751	503	10	(	(	PUNCT
gs-3751	503	11	2023	2023	NUM
gs-3751	503	12	)	)	PUNCT
gs-3751	503	13	.	.	PUNCT
gs-3751	504	1	prebiotics	prebiotic	NOUN
gs-3751	504	2	in	in	ADP
gs-3751	504	3	alzheimer	alzheimer	PROPN
gs-3751	504	4	’s	’s	PART
gs-3751	504	5	disease	disease	NOUN
gs-3751	504	6	:	:	PUNCT
gs-3751	504	7	evidence	evidence	NOUN
gs-3751	504	8	from	from	ADP
gs-3751	504	9	clinical	clinical	ADJ
gs-3751	504	10	trials	trial	NOUN
gs-3751	504	11	.	.	PUNCT
gs-3751	505	1	journal	journal	NOUN
gs-3751	505	2	of	of	ADP
gs-3751	505	3	clinical	clinical	ADJ
gs-3751	505	4	gastroenterology	gastroenterology	NOUN
gs-3751	505	5	,	,	PUNCT
gs-3751	505	6	57(4	57(4	NUM
gs-3751	505	7	)	)	PUNCT
gs-3751	505	8	,	,	PUNCT
gs-3751	505	9	250–260	250–260	NUM
gs-3751	505	10	.	.	PUNCT
gs-3751	506	1	30	30	NUM
gs-3751	506	2	.	.	PUNCT
gs-3751	507	1	nodar	nodar	PROPN
gs-3751	507	2	sulashvili	sulashvili	NOUN
gs-3751	507	3	,	,	PUNCT
gs-3751	507	4	nana	nana	PROPN
gs-3751	507	5	gorgaslidze	gorgaslidze	PROPN
gs-3751	507	6	,	,	PUNCT
gs-3751	507	7	margarita	margarita	PROPN
gs-3751	507	8	beglaryan	beglaryan	PROPN
gs-3751	507	9	,	,	PUNCT
gs-3751	507	10	luiza	luiza	PROPN
gs-3751	507	11	gabunia	gabunia	PROPN
gs-3751	507	12	,	,	PUNCT
gs-3751	507	13	nato	nato	PROPN
gs-3751	507	14	alavidze	alavidze	PROPN
gs-3751	507	15	,	,	PUNCT
gs-3751	507	16	nino	nino	PROPN
gs-3751	507	17	abuladze	abuladze	PROPN
gs-3751	507	18	,	,	PUNCT
gs-3751	507	19	marina	marina	PROPN
gs-3751	507	20	giorgobiani	giorgobiani	PROPN
gs-3751	507	21	,	,	PUNCT
gs-3751	507	22	marika	marika	PROPN
gs-3751	507	23	sulashvili	sulashvili	PROPN
gs-3751	507	24	,	,	PUNCT
gs-3751	507	25	tamar	tamar	PROPN
gs-3751	507	26	okropiridze	okropiridze	PROPN
gs-3751	507	27	,	,	PUNCT
gs-3751	507	28	and	and	CCONJ
gs-3751	507	29	lali	lali	PROPN
gs-3751	507	30	patsia	patsia	PROPN
gs-3751	507	31	.	.	PUNCT
gs-3751	508	1	2025	2025	NUM
gs-3751	508	2	.	.	PUNCT
gs-3751	509	1	“	"	PUNCT
gs-3751	509	2	the	the	DET
gs-3751	509	3	scientific	scientific	ADJ
gs-3751	509	4	discourse	discourse	NOUN
gs-3751	509	5	of	of	ADP
gs-3751	509	6	key	key	ADJ
gs-3751	509	7	issue	issue	NOUN
gs-3751	509	8	aspects	aspect	NOUN
gs-3751	509	9	of	of	ADP
gs-3751	509	10	features	feature	NOUN
gs-3751	509	11	of	of	ADP
gs-3751	509	12	candida	candida	PROPN
gs-3751	509	13	problems	problem	NOUN
gs-3751	509	14	,	,	PUNCT
gs-3751	509	15	antifungal	antifungal	ADJ
gs-3751	509	16	drugs	drug	NOUN
gs-3751	509	17	resistance	resistance	NOUN
gs-3751	509	18	concerns	concern	NOUN
gs-3751	509	19	,	,	PUNCT
gs-3751	509	20	mycotoxicology	mycotoxicology	NOUN
gs-3751	509	21	issues	issue	NOUN
gs-3751	509	22	,	,	PUNCT
gs-3751	509	23	mycoecology	mycoecology	NOUN
gs-3751	509	24	,	,	PUNCT
gs-3751	509	25	biosafety	biosafety	NOUN
gs-3751	509	26	risks	risk	NOUN
gs-3751	509	27	and	and	CCONJ
gs-3751	509	28	emerging	emerge	VERB
gs-3751	509	29	solutions	solution	NOUN
gs-3751	509	30	”	"	PUNCT
gs-3751	509	31	.	.	PUNCT
gs-3751	510	1	modern	modern	ADJ
gs-3751	510	2	scientific	scientific	ADJ
gs-3751	510	3	method	method	NOUN
gs-3751	510	4	,	,	PUNCT
gs-3751	510	5	no	no	INTJ
gs-3751	510	6	.	.	NOUN
gs-3751	510	7	9	9	NUM
gs-3751	510	8	(	(	PUNCT
gs-3751	510	9	march	march	PROPN
gs-3751	510	10	)	)	PUNCT
gs-3751	510	11	.	.	PUNCT
gs-3751	511	1	https://ojs.scipub.de/index.php/msm/article/view/5423	https://ojs.scipub.de/index.php/msm/article/view/5423	NOUN
gs-3751	511	2	.	.	NOUN
gs-3751	511	3	31	31	NUM
gs-3751	511	4	.	.	X
gs-3751	511	5	tang	tang	PROPN
gs-3751	511	6	,	,	PUNCT
gs-3751	511	7	s.	s.	PROPN
gs-3751	511	8	,	,	PUNCT
gs-3751	511	9	&	&	CCONJ
gs-3751	511	10	wu	wu	PROPN
gs-3751	511	11	,	,	PUNCT
gs-3751	511	12	j.	j.	PROPN
gs-3751	511	13	(	(	PUNCT
gs-3751	511	14	2024	2024	NUM
gs-3751	511	15	)	)	PUNCT
gs-3751	511	16	.	.	PUNCT
gs-3751	512	1	role	role	NOUN
gs-3751	512	2	of	of	ADP
gs-3751	512	3	gut	gut	NOUN
gs-3751	512	4	-	-	PUNCT
gs-3751	512	5	brain	brain	NOUN
gs-3751	512	6	axis	axis	NOUN
gs-3751	512	7	in	in	ADP
gs-3751	512	8	parkinson	parkinson	NOUN
gs-3751	512	9	’s	’s	PART
gs-3751	512	10	disease	disease	NOUN
gs-3751	512	11	:	:	PUNCT
gs-3751	512	12	therapeutic	therapeutic	ADJ
gs-3751	512	13	potential	potential	NOUN
gs-3751	512	14	of	of	ADP
gs-3751	512	15	microbiome	microbiome	ADJ
gs-3751	512	16	modulation	modulation	NOUN
gs-3751	512	17	.	.	PUNCT
gs-3751	513	1	molecular	molecular	ADJ
gs-3751	513	2	neurobiology	neurobiology	NOUN
gs-3751	513	3	.	.	PUNCT
gs-3751	514	1	https://doi.org/10.1007/s12035-024-03317-9	https://doi.org/10.1007/s12035-024-03317-9	PROPN
gs-3751	514	2	.	.	PUNCT
gs-3751	515	1	32	32	NUM
gs-3751	515	2	.	.	PUNCT
gs-3751	516	1	gonzalez	gonzalez	PROPN
gs-3751	516	2	,	,	PUNCT
gs-3751	516	3	a.	a.	NOUN
gs-3751	516	4	g.	g.	PROPN
gs-3751	516	5	,	,	PUNCT
gs-3751	516	6	&	&	CCONJ
gs-3751	516	7	ramirez	ramirez	PROPN
gs-3751	516	8	,	,	PUNCT
gs-3751	516	9	f.	f.	PROPN
gs-3751	516	10	j.	j.	PROPN
gs-3751	516	11	(	(	PUNCT
gs-3751	516	12	2023	2023	NUM
gs-3751	516	13	)	)	PUNCT
gs-3751	516	14	.	.	PUNCT
gs-3751	517	1	microbiota	microbiota	NOUN
gs-3751	517	2	in	in	ADP
gs-3751	517	3	alzheimer	alzheimer	PROPN
gs-3751	517	4	’s	’s	PART
gs-3751	517	5	disease	disease	NOUN
gs-3751	517	6	:	:	PUNCT
gs-3751	517	7	pathogenic	pathogenic	ADJ
gs-3751	517	8	pathways	pathway	NOUN
gs-3751	517	9	and	and	CCONJ
gs-3751	517	10	therapeutic	therapeutic	ADJ
gs-3751	517	11	prospects	prospect	NOUN
gs-3751	517	12	.	.	PUNCT
gs-3751	518	1	neurotherapeutics	neurotherapeutic	NOUN
gs-3751	518	2	,	,	PUNCT
gs-3751	518	3	20(1	20(1	NUM
gs-3751	518	4	)	)	PUNCT
gs-3751	518	5	,	,	PUNCT
gs-3751	518	6	12–25	12–25	NUM
gs-3751	518	7	.	.	PUNCT