id	sid	tid	token	lemma	pos
gs-3799	1	1	georgian	georgian	PROPN
gs-3799	1	2	scientists/	scientists/	NUM
gs-3799	1	3	.	.	PUNCT
gs-3799	2	1	7	7	NUM
gs-3799	2	2	n	n	DET
gs-3799	2	3	2	2	NUM
gs-3799	2	4	,	,	PUNCT
gs-3799	2	5	2025	2025	NUM
gs-3799	2	6	381	381	NUM
gs-3799	2	7	georgian	georgian	ADJ
gs-3799	2	8	scientists	scientist	NOUN
gs-3799	2	9	vol	vol	NOUN
gs-3799	2	10	.	.	PUNCT
gs-3799	3	1	7	7	NUM
gs-3799	3	2	issue	issue	NOUN
gs-3799	3	3	2	2	NUM
gs-3799	3	4	,	,	PUNCT
gs-3799	3	5	2025	2025	NUM
gs-3799	3	6	https://doi.org/10.52340/gs.2025.07.02.36	https://doi.org/10.52340/gs.2025.07.02.36	NUM
gs-3799	3	7	closed	close	VERB
gs-3799	3	8	-	-	PUNCT
gs-3799	3	9	loop	loop	NOUN
gs-3799	3	10	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	3	11	bypass	bypass	NOUN
gs-3799	3	12	systems	system	NOUN
gs-3799	3	13	with	with	ADP
gs-3799	3	14	real	real	ADJ
gs-3799	3	15	-	-	PUNCT
gs-3799	3	16	time	time	NOUN
gs-3799	3	17	monitoring	monitoring	NOUN
gs-3799	3	18	and	and	CCONJ
gs-3799	3	19	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	3	20	strategies	strategy	NOUN
gs-3799	3	21	:	:	PUNCT
gs-3799	3	22	innovations	innovation	NOUN
gs-3799	3	23	,	,	PUNCT
gs-3799	3	24	outcomes	outcome	NOUN
gs-3799	3	25	,	,	PUNCT
gs-3799	3	26	clinical	clinical	ADJ
gs-3799	3	27	impact	impact	NOUN
gs-3799	3	28	and	and	CCONJ
gs-3799	3	29	future	future	ADJ
gs-3799	3	30	directions	direction	NOUN
gs-3799	3	31	in	in	ADP
gs-3799	3	32	general	general	ADJ
gs-3799	3	33	nodar	nodar	PROPN
gs-3799	3	34	sulashvili1	sulashvili1	PROPN
gs-3799	3	35	,	,	PUNCT
gs-3799	3	36	sharon	sharon	PROPN
gs-3799	3	37	fernando2	fernando2	PROPN
gs-3799	3	38	,	,	PUNCT
gs-3799	3	39	awad	awad	PROPN
gs-3799	3	40	el	el	PROPN
gs-3799	3	41	-	-	PROPN
gs-3799	3	42	hakeem3	hakeem3	PROPN
gs-3799	3	43	,	,	PUNCT
gs-3799	3	44	luiza	luiza	PROPN
gs-3799	3	45	gabunia4	gabunia4	PROPN
gs-3799	3	46	,	,	PUNCT
gs-3799	3	47	nana	nana	PROPN
gs-3799	3	48	gorgaslidze5	gorgaslidze5	PROPN
gs-3799	3	49	,	,	PUNCT
gs-3799	3	50	margarita	margarita	PROPN
gs-3799	3	51	beglaryan6	beglaryan6	PROPN
gs-3799	3	52	,	,	PUNCT
gs-3799	3	53	lali	lali	PROPN
gs-3799	3	54	patsia7	patsia7	PROPN
gs-3799	3	55	,	,	PUNCT
gs-3799	3	56	natia	natia	PROPN
gs-3799	3	57	kvizhinadze8	kvizhinadze8	PROPN
gs-3799	3	58	,	,	PUNCT
gs-3799	3	59	marika	marika	PROPN
gs-3799	3	60	sulashvili9	sulashvili9	PROPN
gs-3799	3	61	1md	1md	NOUN
gs-3799	3	62	,	,	PUNCT
gs-3799	3	63	phd	phd	NOUN
gs-3799	3	64	,	,	PUNCT
gs-3799	3	65	doctor	doctor	NOUN
gs-3799	3	66	of	of	ADP
gs-3799	3	67	pharmaceutical	pharmaceutical	ADJ
gs-3799	3	68	and	and	CCONJ
gs-3799	3	69	pharmacological	pharmacological	ADJ
gs-3799	3	70	sciences	science	NOUN
gs-3799	3	71	in	in	ADP
gs-3799	3	72	medicine	medicine	NOUN
gs-3799	3	73	,	,	PUNCT
gs-3799	3	74	invited	invite	VERB
gs-3799	3	75	lecturer	lecturer	NOUN
gs-3799	3	76	(	(	PUNCT
gs-3799	3	77	invited	invite	VERB
gs-3799	3	78	professor	professor	NOUN
gs-3799	3	79	)	)	PUNCT
gs-3799	3	80	of	of	ADP
gs-3799	3	81	scientific	scientific	ADJ
gs-3799	3	82	research	research	NOUN
gs-3799	3	83	-	-	PUNCT
gs-3799	3	84	skills	skill	NOUN
gs-3799	3	85	center	center	NOUN
gs-3799	3	86	at	at	ADP
gs-3799	3	87	tbilisi	tbilisi	PROPN
gs-3799	3	88	state	state	PROPN
gs-3799	3	89	medical	medical	PROPN
gs-3799	3	90	university	university	PROPN
gs-3799	3	91	;	;	PUNCT
gs-3799	3	92	professor	professor	NOUN
gs-3799	3	93	of	of	ADP
gs-3799	3	94	medical	medical	ADJ
gs-3799	3	95	and	and	CCONJ
gs-3799	3	96	clinical	clinical	ADJ
gs-3799	3	97	pharmacology	pharmacology	NOUN
gs-3799	3	98	of	of	ADP
gs-3799	3	99	international	international	ADJ
gs-3799	3	100	school	school	NOUN
gs-3799	3	101	of	of	ADP
gs-3799	3	102	medicine	medicine	NOUN
gs-3799	3	103	at	at	ADP
gs-3799	3	104	alte	alte	PROPN
gs-3799	3	105	university	university	PROPN
gs-3799	3	106	;	;	PUNCT
gs-3799	3	107	professor	professor	NOUN
gs-3799	3	108	of	of	ADP
gs-3799	3	109	pharmacology	pharmacology	NOUN
gs-3799	3	110	of	of	ADP
gs-3799	3	111	faculty	faculty	NOUN
gs-3799	3	112	of	of	ADP
gs-3799	3	113	medicine	medicine	NOUN
gs-3799	3	114	at	at	ADP
gs-3799	3	115	georgian	georgian	PROPN
gs-3799	3	116	national	national	PROPN
gs-3799	3	117	university	university	PROPN
gs-3799	3	118	seu	seu	NOUN
gs-3799	3	119	;	;	PUNCT
gs-3799	3	120	associate	associate	ADJ
gs-3799	3	121	affiliated	affiliate	VERB
gs-3799	3	122	professor	professor	NOUN
gs-3799	3	123	of	of	ADP
gs-3799	3	124	medical	medical	ADJ
gs-3799	3	125	pharmacology	pharmacology	NOUN
gs-3799	3	126	of	of	ADP
gs-3799	3	127	faculty	faculty	NOUN
gs-3799	3	128	of	of	ADP
gs-3799	3	129	medicine	medicine	NOUN
gs-3799	3	130	at	at	ADP
gs-3799	3	131	sulkhan	sulkhan	PROPN
gs-3799	3	132	-	-	PUNCT
gs-3799	3	133	saba	saba	PROPN
gs-3799	3	134	orbeliani	orbeliani	PROPN
gs-3799	3	135	university	university	PROPN
gs-3799	3	136	;	;	PUNCT
gs-3799	3	137	associate	associate	NOUN
gs-3799	3	138	professor	professor	NOUN
gs-3799	3	139	of	of	ADP
gs-3799	3	140	pharmacology	pharmacology	NOUN
gs-3799	3	141	of	of	ADP
gs-3799	3	142	pharmacy	pharmacy	NOUN
gs-3799	3	143	program	program	NOUN
gs-3799	3	144	at	at	ADP
gs-3799	3	145	shota	shota	PROPN
gs-3799	3	146	meskhia	meskhia	PROPN
gs-3799	3	147	zugdidi	zugdidi	PROPN
gs-3799	3	148	state	state	PROPN
gs-3799	3	149	university	university	PROPN
gs-3799	3	150	;	;	PUNCT
gs-3799	3	151	associate	associate	NOUN
gs-3799	3	152	professor	professor	NOUN
gs-3799	3	153	of	of	ADP
gs-3799	3	154	medical	medical	ADJ
gs-3799	3	155	pharmacology	pharmacology	NOUN
gs-3799	3	156	at	at	ADP
gs-3799	3	157	school	school	NOUN
gs-3799	3	158	of	of	ADP
gs-3799	3	159	medicine	medicine	NOUN
gs-3799	3	160	at	at	ADP
gs-3799	3	161	david	david	PROPN
gs-3799	3	162	aghmashenebeli	aghmashenebeli	PROPN
gs-3799	3	163	university	university	PROPN
gs-3799	3	164	of	of	ADP
gs-3799	3	165	georgia	georgia	PROPN
gs-3799	3	166	;	;	PUNCT
gs-3799	3	167	associate	associate	NOUN
gs-3799	3	168	professor	professor	NOUN
gs-3799	3	169	of	of	ADP
gs-3799	3	170	biochemistry	biochemistry	NOUN
gs-3799	3	171	and	and	CCONJ
gs-3799	3	172	pharmacology	pharmacology	NOUN
gs-3799	3	173	direction	direction	NOUN
gs-3799	3	174	of	of	ADP
gs-3799	3	175	school	school	NOUN
gs-3799	3	176	of	of	ADP
gs-3799	3	177	health	health	NOUN
gs-3799	3	178	sciences	science	NOUN
gs-3799	3	179	at	at	ADP
gs-3799	3	180	the	the	DET
gs-3799	3	181	university	university	PROPN
gs-3799	3	182	of	of	ADP
gs-3799	3	183	georgia	georgia	PROPN
gs-3799	3	184	;	;	PUNCT
gs-3799	3	185	associate	associate	NOUN
gs-3799	3	186	professor	professor	NOUN
gs-3799	3	187	of	of	ADP
gs-3799	3	188	pharmacology	pharmacology	NOUN
gs-3799	3	189	of	of	ADP
gs-3799	3	190	faculty	faculty	NOUN
gs-3799	3	191	of	of	ADP
gs-3799	3	192	medicine	medicine	NOUN
gs-3799	3	193	at	at	ADP
gs-3799	3	194	east	east	PROPN
gs-3799	3	195	european	european	PROPN
gs-3799	3	196	university	university	PROPN
gs-3799	3	197	;	;	PUNCT
gs-3799	3	198	associate	associate	NOUN
gs-3799	3	199	professor	professor	NOUN
gs-3799	3	200	of	of	ADP
gs-3799	3	201	pharmacology	pharmacology	NOUN
gs-3799	3	202	of	of	ADP
gs-3799	3	203	faculty	faculty	NOUN
gs-3799	3	204	of	of	ADP
gs-3799	3	205	dentistry	dentistry	NOUN
gs-3799	3	206	and	and	CCONJ
gs-3799	3	207	pharmacy	pharmacy	NOUN
gs-3799	3	208	at	at	ADP
gs-3799	3	209	tbilisi	tbilisi	ADJ
gs-3799	3	210	humanitarian	humanitarian	ADJ
gs-3799	3	211	teaching	teaching	NOUN
gs-3799	3	212	university	university	NOUN
gs-3799	3	213	;	;	PUNCT
gs-3799	3	214	tbilisi	tbilisi	PROPN
gs-3799	3	215	,	,	PUNCT
gs-3799	3	216	georgia	georgia	PROPN
gs-3799	3	217	;	;	PUNCT
gs-3799	3	218	researcher	researcher	NOUN
gs-3799	3	219	of	of	ADP
gs-3799	3	220	department	department	PROPN
gs-3799	3	221	of	of	ADP
gs-3799	3	222	pharmaceutical	pharmaceutical	ADJ
gs-3799	3	223	management	management	NOUN
gs-3799	3	224	of	of	ADP
gs-3799	3	225	yerevan	yerevan	PROPN
gs-3799	3	226	state	state	PROPN
gs-3799	3	227	medical	medical	PROPN
gs-3799	3	228	university	university	PROPN
gs-3799	3	229	after	after	ADP
gs-3799	3	230	mkhitar	mkhitar	NOUN
gs-3799	3	231	heratsi	heratsi	PROPN
gs-3799	3	232	,	,	PUNCT
gs-3799	3	233	yerevan	yerevan	PROPN
gs-3799	3	234	,	,	PUNCT
gs-3799	3	235	armenia	armenia	PROPN
gs-3799	3	236	.	.	PUNCT
gs-3799	4	1	orcid	orcid	PROPN
gs-3799	4	2	https://orcid.org/0000-0002-9005-8577	https://orcid.org/0000-0002-9005-8577	PROPN
gs-3799	4	3	e	e	NOUN
gs-3799	4	4	-	-	NOUN
gs-3799	4	5	mail	mail	NOUN
gs-3799	4	6	:	:	PUNCT
gs-3799	4	7	n.sulashvili@ug.edu.ge	n.sulashvili@ug.edu.ge	PROPN
gs-3799	4	8	25th	25th	ADJ
gs-3799	4	9	-	-	PUNCT
gs-3799	4	10	year	year	NOUN
gs-3799	4	11	md	md	PROPN
gs-3799	4	12	student	student	NOUN
gs-3799	4	13	at	at	ADP
gs-3799	4	14	the	the	DET
gs-3799	4	15	faculty	faculty	NOUN
gs-3799	4	16	of	of	ADP
gs-3799	4	17	medicine	medicine	NOUN
gs-3799	4	18	,	,	PUNCT
gs-3799	4	19	tbilisi	tbilisi	PROPN
gs-3799	4	20	state	state	PROPN
gs-3799	4	21	medical	medical	PROPN
gs-3799	4	22	university	university	PROPN
gs-3799	4	23	,	,	PUNCT
gs-3799	4	24	tbilisi	tbilisi	PROPN
gs-3799	4	25	,	,	PUNCT
gs-3799	4	26	georgia	georgia	PROPN
gs-3799	4	27	;	;	PUNCT
gs-3799	4	28	35th	35th	ADJ
gs-3799	4	29	-	-	PUNCT
gs-3799	4	30	year	year	NOUN
gs-3799	4	31	md	md	PROPN
gs-3799	4	32	student	student	NOUN
gs-3799	4	33	at	at	ADP
gs-3799	4	34	the	the	DET
gs-3799	4	35	faculty	faculty	NOUN
gs-3799	4	36	of	of	ADP
gs-3799	4	37	medicine	medicine	NOUN
gs-3799	4	38	,	,	PUNCT
gs-3799	4	39	tbilisi	tbilisi	PROPN
gs-3799	4	40	state	state	PROPN
gs-3799	4	41	medical	medical	PROPN
gs-3799	4	42	university	university	PROPN
gs-3799	4	43	,	,	PUNCT
gs-3799	4	44	tbilisi	tbilisi	PROPN
gs-3799	4	45	,	,	PUNCT
gs-3799	4	46	georgia	georgia	PROPN
gs-3799	4	47	;	;	PUNCT
gs-3799	5	1	4md	4md	ADJ
gs-3799	5	2	,	,	PUNCT
gs-3799	5	3	phd	phd	NOUN
gs-3799	5	4	,	,	PUNCT
gs-3799	5	5	doctor	doctor	NOUN
gs-3799	5	6	of	of	ADP
gs-3799	5	7	medical	medical	ADJ
gs-3799	5	8	sciences	sciences	PROPN
gs-3799	5	9	,	,	PUNCT
gs-3799	5	10	professor	professor	NOUN
gs-3799	5	11	,	,	PUNCT
gs-3799	5	12	director	director	NOUN
gs-3799	5	13	of	of	ADP
gs-3799	5	14	the	the	DET
gs-3799	5	15	scientific	scientific	ADJ
gs-3799	5	16	research	research	NOUN
gs-3799	5	17	-	-	PUNCT
gs-3799	5	18	skills	skill	NOUN
gs-3799	5	19	center	center	NOUN
gs-3799	5	20	at	at	ADP
gs-3799	5	21	tbilisi	tbilisi	PROPN
gs-3799	5	22	state	state	PROPN
gs-3799	5	23	medical	medical	PROPN
gs-3799	5	24	university	university	PROPN
gs-3799	5	25	,	,	PUNCT
gs-3799	5	26	professor	professor	NOUN
gs-3799	5	27	,	,	PUNCT
gs-3799	5	28	head	head	NOUN
gs-3799	5	29	of	of	ADP
gs-3799	5	30	the	the	DET
gs-3799	5	31	department	department	PROPN
gs-3799	5	32	of	of	ADP
gs-3799	5	33	medical	medical	ADJ
gs-3799	5	34	and	and	CCONJ
gs-3799	5	35	clinical	clinical	ADJ
gs-3799	5	36	pharmacology	pharmacology	NOUN
gs-3799	5	37	at	at	ADP
gs-3799	5	38	tbilisi	tbilisi	PROPN
gs-3799	5	39	state	state	PROPN
gs-3799	5	40	medical	medical	PROPN
gs-3799	5	41	university	university	PROPN
gs-3799	5	42	,	,	PUNCT
gs-3799	5	43	clinical	clinical	ADJ
gs-3799	5	44	pharmacologist	pharmacologist	NOUN
gs-3799	5	45	of	of	ADP
gs-3799	5	46	the	the	DET
gs-3799	5	47	first	first	ADJ
gs-3799	5	48	university	university	NOUN
gs-3799	5	49	clinic	clinic	NOUN
gs-3799	5	50	of	of	ADP
gs-3799	5	51	tbilisi	tbilisi	PROPN
gs-3799	5	52	state	state	PROPN
gs-3799	5	53	medical	medical	PROPN
gs-3799	5	54	university	university	PROPN
gs-3799	5	55	,	,	PUNCT
gs-3799	5	56	tbilisi	tbilisi	PROPN
gs-3799	5	57	,	,	PUNCT
gs-3799	5	58	georgia	georgia	PROPN
gs-3799	5	59	https://orcid.org/0000-0003-0856-2684	https://orcid.org/0000-0003-0856-2684	PROPN
gs-3799	5	60	5md	5md	PROPN
gs-3799	5	61	,	,	PUNCT
gs-3799	5	62	phd	phd	NOUN
gs-3799	5	63	,	,	PUNCT
gs-3799	5	64	doctor	doctor	NOUN
gs-3799	5	65	of	of	ADP
gs-3799	5	66	pharmaceutical	pharmaceutical	NOUN
gs-3799	5	67	sciences	science	NOUN
gs-3799	5	68	,	,	PUNCT
gs-3799	5	69	academician	academician	NOUN
gs-3799	5	70	,	,	PUNCT
gs-3799	5	71	professor	professor	NOUN
gs-3799	5	72	of	of	ADP
gs-3799	5	73	tbilisi	tbilisi	PROPN
gs-3799	5	74	state	state	PROPN
gs-3799	5	75	medical	medical	PROPN
gs-3799	5	76	university	university	PROPN
gs-3799	5	77	,	,	PUNCT
gs-3799	5	78	head	head	NOUN
gs-3799	5	79	of	of	ADP
gs-3799	5	80	the	the	DET
gs-3799	5	81	department	department	NOUN
gs-3799	5	82	of	of	ADP
gs-3799	5	83	social	social	ADJ
gs-3799	5	84	and	and	CCONJ
gs-3799	5	85	clinical	clinical	ADJ
gs-3799	5	86	pharmacy	pharmacy	NOUN
gs-3799	5	87	,	,	PUNCT
gs-3799	5	88	tbilisi	tbilisi	PROPN
gs-3799	5	89	,	,	PUNCT
gs-3799	5	90	georgia	georgia	PROPN
gs-3799	5	91	.	.	PUNCT
gs-3799	6	1	https://orcid.org/0000-0002-4563-5224	https://orcid.org/0000-0002-4563-5224	PROPN
gs-3799	6	2	6md	6md	PROPN
gs-3799	6	3	,	,	PUNCT
gs-3799	6	4	phd	phd	NOUN
gs-3799	6	5	,	,	PUNCT
gs-3799	6	6	doctor	doctor	NOUN
gs-3799	6	7	of	of	ADP
gs-3799	6	8	pharmaceutical	pharmaceutical	NOUN
gs-3799	6	9	sciences	science	NOUN
gs-3799	6	10	,	,	PUNCT
gs-3799	6	11	academician	academician	NOUN
gs-3799	6	12	,	,	PUNCT
gs-3799	6	13	professor	professor	NOUN
gs-3799	6	14	of	of	ADP
gs-3799	6	15	yerevan	yerevan	PROPN
gs-3799	6	16	state	state	PROPN
gs-3799	6	17	medical	medical	PROPN
gs-3799	6	18	university	university	PROPN
gs-3799	6	19	after	after	ADP
gs-3799	6	20	mkhitar	mkhitar	NOUN
gs-3799	6	21	heratsi	heratsi	PROPN
gs-3799	6	22	,	,	PUNCT
gs-3799	6	23	head	head	NOUN
gs-3799	6	24	of	of	ADP
gs-3799	6	25	the	the	DET
gs-3799	6	26	department	department	PROPN
gs-3799	6	27	of	of	ADP
gs-3799	6	28	pharmaceutical	pharmaceutical	NOUN
gs-3799	6	29	management	management	NOUN
gs-3799	6	30	,	,	PUNCT
gs-3799	6	31	president	president	NOUN
gs-3799	6	32	of	of	ADP
gs-3799	6	33	association	association	PROPN
gs-3799	6	34	phesa	phesa	PROPN
gs-3799	6	35	(	(	PUNCT
gs-3799	6	36	pharmacy	pharmacy	NOUN
gs-3799	6	37	and	and	CCONJ
gs-3799	6	38	pharmacology	pharmacology	NOUN
gs-3799	6	39	education	education	NOUN
gs-3799	6	40	and	and	CCONJ
gs-3799	6	41	science	science	NOUN
gs-3799	6	42	association	association	PROPN
gs-3799	6	43	)	)	PUNCT
gs-3799	6	44	,	,	PUNCT
gs-3799	6	45	yerevan	yerevan	PROPN
gs-3799	6	46	,	,	PUNCT
gs-3799	6	47	armenia	armenia	PROPN
gs-3799	6	48	;	;	PUNCT
gs-3799	6	49	https://orcid.org/0000-0003-3697-6390	https://orcid.org/0000-0003-3697-6390	PROPN
gs-3799	6	50	7md	7md	NOUN
gs-3799	6	51	,	,	PUNCT
gs-3799	6	52	phd	phd	NOUN
gs-3799	6	53	,	,	PUNCT
gs-3799	6	54	doctor	doctor	NOUN
gs-3799	6	55	of	of	ADP
gs-3799	6	56	medical	medical	ADJ
gs-3799	6	57	sciences	science	NOUN
gs-3799	6	58	,	,	PUNCT
gs-3799	6	59	doctor	doctor	NOUN
gs-3799	6	60	cardiologist	cardiologist	NOUN
gs-3799	6	61	at	at	ADP
gs-3799	6	62	republican	republican	ADJ
gs-3799	6	63	hospital	hospital	NOUN
gs-3799	6	64	,	,	PUNCT
gs-3799	6	65	invited	invite	VERB
gs-3799	6	66	professor	professor	NOUN
gs-3799	6	67	of	of	ADP
gs-3799	6	68	tbilisi	tbilisi	PROPN
gs-3799	6	69	state	state	PROPN
gs-3799	6	70	medical	medical	PROPN
gs-3799	6	71	university	university	PROPN
gs-3799	6	72	,	,	PUNCT
gs-3799	6	73	professor	professor	NOUN
gs-3799	6	74	of	of	ADP
gs-3799	6	75	ken	ken	PROPN
gs-3799	6	76	walker	walker	PROPN
gs-3799	6	77	international	international	PROPN
gs-3799	6	78	university	university	PROPN
gs-3799	6	79	,	,	PUNCT
gs-3799	6	80	professor	professor	NOUN
gs-3799	6	81	of	of	ADP
gs-3799	6	82	international	international	ADJ
gs-3799	6	83	school	school	NOUN
gs-3799	6	84	of	of	ADP
gs-3799	6	85	medicine	medicine	NOUN
gs-3799	6	86	at	at	ADP
gs-3799	6	87	alte	alte	PROPN
gs-3799	6	88	university	university	PROPN
gs-3799	6	89	,	,	PUNCT
gs-3799	6	90	professor	professor	NOUN
gs-3799	6	91	of	of	ADP
gs-3799	6	92	faculty	faculty	NOUN
gs-3799	6	93	of	of	ADP
gs-3799	6	94	medicine	medicine	NOUN
gs-3799	6	95	at	at	ADP
gs-3799	6	96	sulkhan	sulkhan	PROPN
gs-3799	6	97	-	-	PUNCT
gs-3799	6	98	saba	saba	PROPN
gs-3799	6	99	orbeliani	orbeliani	PROPN
gs-3799	6	100	university	university	PROPN
gs-3799	6	101	,	,	PUNCT
gs-3799	6	102	tbilisi	tbilisi	PROPN
gs-3799	6	103	,	,	PUNCT
gs-3799	6	104	georgia	georgia	PROPN
gs-3799	6	105	.	.	PUNCT
gs-3799	7	1	8md	8md	PROPN
gs-3799	7	2	,	,	PUNCT
gs-3799	7	3	phd	phd	NOUN
gs-3799	7	4	,	,	PUNCT
gs-3799	7	5	doctor	doctor	NOUN
gs-3799	7	6	of	of	ADP
gs-3799	7	7	pharmaceutical	pharmaceutical	NOUN
gs-3799	7	8	sciences	science	NOUN
gs-3799	7	9	,	,	PUNCT
gs-3799	7	10	professor	professor	NOUN
gs-3799	7	11	of	of	ADP
gs-3799	7	12	tbilisi	tbilisi	PROPN
gs-3799	7	13	state	state	PROPN
gs-3799	7	14	medical	medical	PROPN
gs-3799	7	15	university	university	PROPN
gs-3799	7	16	,	,	PUNCT
gs-3799	7	17	department	department	NOUN
gs-3799	7	18	of	of	ADP
gs-3799	7	19	social	social	ADJ
gs-3799	7	20	and	and	CCONJ
gs-3799	7	21	clinical	clinical	ADJ
gs-3799	7	22	pharmacy	pharmacy	NOUN
gs-3799	7	23	;	;	PUNCT
gs-3799	7	24	tbilisi	tbilisi	PROPN
gs-3799	7	25	,	,	PUNCT
gs-3799	7	26	georgia	georgia	PROPN
gs-3799	7	27	.	.	PUNCT
gs-3799	8	1	9md	9md	NOUN
gs-3799	8	2	,	,	PUNCT
gs-3799	8	3	doctor	doctor	NOUN
gs-3799	8	4	of	of	ADP
gs-3799	8	5	family	family	NOUN
gs-3799	8	6	medicine	medicine	NOUN
gs-3799	8	7	,	,	PUNCT
gs-3799	8	8	invited	invite	VERB
gs-3799	8	9	lecturer	lecturer	NOUN
gs-3799	8	10	of	of	ADP
gs-3799	8	11	tbilisi	tbilisi	PROPN
gs-3799	8	12	state	state	PROPN
gs-3799	8	13	medical	medical	PROPN
gs-3799	8	14	university	university	PROPN
gs-3799	8	15	,	,	PUNCT
gs-3799	8	16	department	department	NOUN
gs-3799	8	17	of	of	ADP
gs-3799	8	18	molecular	molecular	ADJ
gs-3799	8	19	and	and	CCONJ
gs-3799	8	20	medical	medical	ADJ
gs-3799	8	21	genetics	genetic	NOUN
gs-3799	8	22	,	,	PUNCT
gs-3799	8	23	invited	invite	VERB
gs-3799	8	24	professor	professor	NOUN
gs-3799	8	25	of	of	ADP
gs-3799	8	26	biochemistry	biochemistry	NOUN
gs-3799	8	27	and	and	CCONJ
gs-3799	8	28	molecular	molecular	ADJ
gs-3799	8	29	and	and	CCONJ
gs-3799	8	30	medical	medical	ADJ
gs-3799	8	31	genetics	genetic	NOUN
gs-3799	8	32	at	at	ADP
gs-3799	8	33	the	the	DET
gs-3799	8	34	university	university	PROPN
gs-3799	8	35	of	of	ADP
gs-3799	8	36	georgia	georgia	PROPN
gs-3799	8	37	.	.	PUNCT
gs-3799	9	1	tbilisi	tbilisi	PROPN
gs-3799	9	2	,	,	PUNCT
gs-3799	9	3	georgia	georgia	PROPN
gs-3799	9	4	.	.	PUNCT
gs-3799	10	1	orcid	orcid	PROPN
gs-3799	10	2	https://orcid.org/0000-0002-6338-4262	https://orcid.org/0000-0002-6338-4262	PROPN
gs-3799	10	3	.	.	PUNCT
gs-3799	11	1	georgian	georgian	NOUN
gs-3799	11	2	scientists/	scientists/	NUM
gs-3799	11	3	.	.	PUNCT
gs-3799	12	1	7	7	NUM
gs-3799	12	2	n	n	DET
gs-3799	12	3	2	2	NUM
gs-3799	12	4	,	,	PUNCT
gs-3799	12	5	2025	2025	NUM
gs-3799	12	6	382	382	NUM
gs-3799	12	7	abstract	abstract	ADJ
gs-3799	12	8	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	12	9	bypass	bypass	NOUN
gs-3799	12	10	(	(	PUNCT
gs-3799	12	11	cpb	cpb	NOUN
gs-3799	12	12	)	)	PUNCT
gs-3799	12	13	systems	system	NOUN
gs-3799	12	14	are	be	AUX
gs-3799	12	15	a	a	DET
gs-3799	12	16	critical	critical	ADJ
gs-3799	12	17	component	component	NOUN
gs-3799	12	18	in	in	ADP
gs-3799	12	19	modern	modern	ADJ
gs-3799	12	20	cardiac	cardiac	ADJ
gs-3799	12	21	surgery	surgery	NOUN
gs-3799	12	22	,	,	PUNCT
gs-3799	12	23	supporting	support	VERB
gs-3799	12	24	the	the	DET
gs-3799	12	25	circulation	circulation	NOUN
gs-3799	12	26	and	and	CCONJ
gs-3799	12	27	oxygenation	oxygenation	NOUN
gs-3799	12	28	of	of	ADP
gs-3799	12	29	blood	blood	NOUN
gs-3799	12	30	during	during	ADP
gs-3799	12	31	procedures	procedure	NOUN
gs-3799	12	32	that	that	PRON
gs-3799	12	33	require	require	VERB
gs-3799	12	34	the	the	DET
gs-3799	12	35	temporary	temporary	ADJ
gs-3799	12	36	cessation	cessation	NOUN
gs-3799	12	37	of	of	ADP
gs-3799	12	38	heart	heart	NOUN
gs-3799	12	39	and	and	CCONJ
gs-3799	12	40	lung	lung	NOUN
gs-3799	12	41	function	function	NOUN
gs-3799	12	42	.	.	PUNCT
gs-3799	13	1	traditional	traditional	ADJ
gs-3799	13	2	cpb	cpb	PROPN
gs-3799	13	3	systems	system	NOUN
gs-3799	13	4	,	,	PUNCT
gs-3799	13	5	however	however	ADV
gs-3799	13	6	,	,	PUNCT
gs-3799	13	7	are	be	AUX
gs-3799	13	8	open	open	ADJ
gs-3799	13	9	-	-	PUNCT
gs-3799	13	10	loop	loop	NOUN
gs-3799	13	11	and	and	CCONJ
gs-3799	13	12	operator	operator	NOUN
gs-3799	13	13	-	-	PUNCT
gs-3799	13	14	dependent	dependent	ADJ
gs-3799	13	15	,	,	PUNCT
gs-3799	13	16	often	often	ADV
gs-3799	13	17	limited	limit	VERB
gs-3799	13	18	by	by	ADP
gs-3799	13	19	delayed	delay	VERB
gs-3799	13	20	response	response	NOUN
gs-3799	13	21	times	time	NOUN
gs-3799	13	22	,	,	PUNCT
gs-3799	13	23	suboptimal	suboptimal	ADJ
gs-3799	13	24	control	control	NOUN
gs-3799	13	25	of	of	ADP
gs-3799	13	26	hemodynamics	hemodynamic	NOUN
gs-3799	13	27	,	,	PUNCT
gs-3799	13	28	and	and	CCONJ
gs-3799	13	29	variability	variability	NOUN
gs-3799	13	30	in	in	ADP
gs-3799	13	31	pharmacologic	pharmacologic	ADJ
gs-3799	13	32	interventions	intervention	NOUN
gs-3799	13	33	.	.	PUNCT
gs-3799	14	1	in	in	ADP
gs-3799	14	2	recent	recent	ADJ
gs-3799	14	3	years	year	NOUN
gs-3799	14	4	,	,	PUNCT
gs-3799	14	5	the	the	DET
gs-3799	14	6	integration	integration	NOUN
gs-3799	14	7	of	of	ADP
gs-3799	14	8	closed	closed	ADJ
gs-3799	14	9	-	-	PUNCT
gs-3799	14	10	loop	loop	NOUN
gs-3799	14	11	control	control	NOUN
gs-3799	14	12	mechanisms	mechanism	NOUN
gs-3799	14	13	,	,	PUNCT
gs-3799	14	14	realtime	realtime	ADJ
gs-3799	14	15	monitoring	monitoring	NOUN
gs-3799	14	16	,	,	PUNCT
gs-3799	14	17	and	and	CCONJ
gs-3799	14	18	advanced	advanced	ADJ
gs-3799	14	19	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	14	20	strategies	strategy	NOUN
gs-3799	14	21	has	have	AUX
gs-3799	14	22	marked	mark	VERB
gs-3799	14	23	a	a	DET
gs-3799	14	24	transformative	transformative	ADJ
gs-3799	14	25	shift	shift	NOUN
gs-3799	14	26	in	in	ADP
gs-3799	14	27	the	the	DET
gs-3799	14	28	design	design	NOUN
gs-3799	14	29	and	and	CCONJ
gs-3799	14	30	application	application	NOUN
gs-3799	14	31	of	of	ADP
gs-3799	14	32	cpb	cpb	PROPN
gs-3799	14	33	technologies	technology	NOUN
gs-3799	14	34	.	.	PUNCT
gs-3799	15	1	this	this	DET
gs-3799	15	2	paper	paper	NOUN
gs-3799	15	3	explores	explore	VERB
gs-3799	15	4	the	the	DET
gs-3799	15	5	features	feature	NOUN
gs-3799	15	6	,	,	PUNCT
gs-3799	15	7	innovations	innovation	NOUN
gs-3799	15	8	,	,	PUNCT
gs-3799	15	9	outcomes	outcome	NOUN
gs-3799	15	10	,	,	PUNCT
gs-3799	15	11	and	and	CCONJ
gs-3799	15	12	future	future	ADJ
gs-3799	15	13	directions	direction	NOUN
gs-3799	15	14	of	of	ADP
gs-3799	15	15	these	these	DET
gs-3799	15	16	next	next	ADJ
gs-3799	15	17	-	-	PUNCT
gs-3799	15	18	generation	generation	NOUN
gs-3799	15	19	closed	close	VERB
gs-3799	15	20	-	-	PUNCT
gs-3799	15	21	loop	loop	NOUN
gs-3799	15	22	cpb	cpb	PROPN
gs-3799	15	23	systems	system	NOUN
gs-3799	15	24	.	.	PUNCT
gs-3799	16	1	closed	close	VERB
gs-3799	16	2	-	-	PUNCT
gs-3799	16	3	loop	loop	NOUN
gs-3799	16	4	cpb	cpb	NOUN
gs-3799	16	5	systems	system	NOUN
gs-3799	16	6	incorporate	incorporate	VERB
gs-3799	16	7	feedback	feedback	NOUN
gs-3799	16	8	-	-	PUNCT
gs-3799	16	9	controlled	control	VERB
gs-3799	16	10	algorithms	algorithm	NOUN
gs-3799	16	11	that	that	PRON
gs-3799	16	12	autonomously	autonomously	ADV
gs-3799	16	13	adjust	adjust	VERB
gs-3799	16	14	key	key	ADJ
gs-3799	16	15	parameters	parameter	NOUN
gs-3799	16	16	such	such	ADJ
gs-3799	16	17	as	as	ADP
gs-3799	16	18	perfusion	perfusion	NOUN
gs-3799	16	19	pressure	pressure	NOUN
gs-3799	16	20	,	,	PUNCT
gs-3799	16	21	flow	flow	NOUN
gs-3799	16	22	rate	rate	NOUN
gs-3799	16	23	,	,	PUNCT
gs-3799	16	24	oxygen	oxygen	NOUN
gs-3799	16	25	delivery	delivery	NOUN
gs-3799	16	26	,	,	PUNCT
gs-3799	16	27	temperature	temperature	NOUN
gs-3799	16	28	,	,	PUNCT
gs-3799	16	29	and	and	CCONJ
gs-3799	16	30	acid	acid	ADJ
gs-3799	16	31	-	-	PUNCT
gs-3799	16	32	base	base	NOUN
gs-3799	16	33	balance	balance	NOUN
gs-3799	16	34	.	.	PUNCT
gs-3799	17	1	these	these	DET
gs-3799	17	2	systems	system	NOUN
gs-3799	17	3	leverage	leverage	VERB
gs-3799	17	4	continuous	continuous	ADJ
gs-3799	17	5	data	datum	NOUN
gs-3799	17	6	input	input	NOUN
gs-3799	17	7	from	from	ADP
gs-3799	17	8	sophisticated	sophisticated	ADJ
gs-3799	17	9	monitoring	monitoring	NOUN
gs-3799	17	10	sensors	sensor	NOUN
gs-3799	17	11	to	to	PART
gs-3799	17	12	dynamically	dynamically	ADV
gs-3799	17	13	maintain	maintain	VERB
gs-3799	17	14	homeostasis	homeostasis	NOUN
gs-3799	17	15	,	,	PUNCT
gs-3799	17	16	thereby	thereby	ADV
gs-3799	17	17	reducing	reduce	VERB
gs-3799	17	18	the	the	DET
gs-3799	17	19	burden	burden	NOUN
gs-3799	17	20	on	on	ADP
gs-3799	17	21	clinical	clinical	ADJ
gs-3799	17	22	personnel	personnel	NOUN
gs-3799	17	23	and	and	CCONJ
gs-3799	17	24	minimizing	minimize	VERB
gs-3799	17	25	the	the	DET
gs-3799	17	26	risks	risk	NOUN
gs-3799	17	27	of	of	ADP
gs-3799	17	28	human	human	ADJ
gs-3799	17	29	error	error	NOUN
gs-3799	17	30	.	.	PUNCT
gs-3799	18	1	real	real	ADJ
gs-3799	18	2	-	-	PUNCT
gs-3799	18	3	time	time	NOUN
gs-3799	18	4	monitoring	monitoring	NOUN
gs-3799	18	5	includes	include	VERB
gs-3799	18	6	parameters	parameter	NOUN
gs-3799	18	7	such	such	ADJ
gs-3799	18	8	as	as	ADP
gs-3799	18	9	arterial	arterial	NOUN
gs-3799	18	10	and	and	CCONJ
gs-3799	18	11	venous	venous	ADJ
gs-3799	18	12	blood	blood	NOUN
gs-3799	18	13	gases	gas	NOUN
gs-3799	18	14	,	,	PUNCT
gs-3799	18	15	lactate	lactate	NOUN
gs-3799	18	16	levels	level	NOUN
gs-3799	18	17	,	,	PUNCT
gs-3799	18	18	hemoglobin	hemoglobin	NOUN
gs-3799	18	19	concentration	concentration	NOUN
gs-3799	18	20	,	,	PUNCT
gs-3799	18	21	systemic	systemic	ADJ
gs-3799	18	22	vascular	vascular	ADJ
gs-3799	18	23	resistance	resistance	NOUN
gs-3799	18	24	,	,	PUNCT
gs-3799	18	25	and	and	CCONJ
gs-3799	18	26	cerebral	cerebral	ADJ
gs-3799	18	27	oximetry	oximetry	NOUN
gs-3799	18	28	,	,	PUNCT
gs-3799	18	29	all	all	PRON
gs-3799	18	30	of	of	ADP
gs-3799	18	31	which	which	PRON
gs-3799	18	32	inform	inform	VERB
gs-3799	18	33	precise	precise	ADJ
gs-3799	18	34	adjustments	adjustment	NOUN
gs-3799	18	35	in	in	ADP
gs-3799	18	36	perfusion	perfusion	NOUN
gs-3799	18	37	and	and	CCONJ
gs-3799	18	38	pharmacologic	pharmacologic	ADJ
gs-3799	18	39	dosing	dosing	NOUN
gs-3799	18	40	.	.	PUNCT
gs-3799	19	1	the	the	DET
gs-3799	19	2	integration	integration	NOUN
gs-3799	19	3	of	of	ADP
gs-3799	19	4	biosensors	biosensor	NOUN
gs-3799	19	5	and	and	CCONJ
gs-3799	19	6	digital	digital	ADJ
gs-3799	19	7	health	health	NOUN
gs-3799	19	8	platforms	platform	NOUN
gs-3799	19	9	facilitates	facilitate	VERB
gs-3799	19	10	constant	constant	ADJ
gs-3799	19	11	communication	communication	NOUN
gs-3799	19	12	between	between	ADP
gs-3799	19	13	physiological	physiological	ADJ
gs-3799	19	14	data	datum	NOUN
gs-3799	19	15	and	and	CCONJ
gs-3799	19	16	therapeutic	therapeutic	ADJ
gs-3799	19	17	interventions	intervention	NOUN
gs-3799	19	18	.	.	PUNCT
gs-3799	20	1	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	20	2	during	during	ADP
gs-3799	20	3	cpb	cpb	PROPN
gs-3799	20	4	is	be	AUX
gs-3799	20	5	equally	equally	ADV
gs-3799	20	6	enhanced	enhance	VERB
gs-3799	20	7	through	through	ADP
gs-3799	20	8	automation	automation	NOUN
gs-3799	20	9	.	.	PUNCT
gs-3799	21	1	the	the	DET
gs-3799	21	2	inclusion	inclusion	NOUN
gs-3799	21	3	of	of	ADP
gs-3799	21	4	infusion	infusion	NOUN
gs-3799	21	5	pumps	pump	NOUN
gs-3799	21	6	and	and	CCONJ
gs-3799	21	7	smart	smart	ADJ
gs-3799	21	8	drug	drug	NOUN
gs-3799	21	9	delivery	delivery	NOUN
gs-3799	21	10	platforms	platform	NOUN
gs-3799	21	11	enables	enable	VERB
gs-3799	21	12	precise	precise	ADJ
gs-3799	21	13	titration	titration	NOUN
gs-3799	21	14	of	of	ADP
gs-3799	21	15	vasoactive	vasoactive	ADJ
gs-3799	21	16	drugs	drug	NOUN
gs-3799	21	17	,	,	PUNCT
gs-3799	21	18	anticoagulants	anticoagulant	NOUN
gs-3799	21	19	,	,	PUNCT
gs-3799	21	20	anesthetics	anesthetic	NOUN
gs-3799	21	21	,	,	PUNCT
gs-3799	21	22	and	and	CCONJ
gs-3799	21	23	anti	anti	ADJ
gs-3799	21	24	-	-	ADJ
gs-3799	21	25	inflammatory	inflammatory	ADJ
gs-3799	21	26	agents	agent	NOUN
gs-3799	21	27	based	base	VERB
gs-3799	21	28	on	on	ADP
gs-3799	21	29	real	real	ADJ
gs-3799	21	30	-	-	PUNCT
gs-3799	21	31	time	time	NOUN
gs-3799	21	32	physiological	physiological	ADJ
gs-3799	21	33	feedback	feedback	NOUN
gs-3799	21	34	.	.	PUNCT
gs-3799	22	1	algorithms	algorithm	NOUN
gs-3799	22	2	programmed	program	VERB
gs-3799	22	3	into	into	ADP
gs-3799	22	4	closed	closed	ADJ
gs-3799	22	5	-	-	PUNCT
gs-3799	22	6	loop	loop	NOUN
gs-3799	22	7	systems	system	NOUN
gs-3799	22	8	can	can	AUX
gs-3799	22	9	adapt	adapt	VERB
gs-3799	22	10	drug	drug	NOUN
gs-3799	22	11	dosages	dosage	NOUN
gs-3799	22	12	in	in	ADP
gs-3799	22	13	response	response	NOUN
gs-3799	22	14	to	to	ADP
gs-3799	22	15	shifting	shift	VERB
gs-3799	22	16	clinical	clinical	ADJ
gs-3799	22	17	conditions	condition	NOUN
gs-3799	22	18	,	,	PUNCT
gs-3799	22	19	optimizing	optimize	VERB
gs-3799	22	20	hemodynamic	hemodynamic	ADJ
gs-3799	22	21	stability	stability	NOUN
gs-3799	22	22	and	and	CCONJ
gs-3799	22	23	reducing	reduce	VERB
gs-3799	22	24	the	the	DET
gs-3799	22	25	incidence	incidence	NOUN
gs-3799	22	26	of	of	ADP
gs-3799	22	27	complications	complication	NOUN
gs-3799	22	28	such	such	ADJ
gs-3799	22	29	as	as	ADP
gs-3799	22	30	ischemia	ischemia	NOUN
gs-3799	22	31	,	,	PUNCT
gs-3799	22	32	coagulopathy	coagulopathy	ADJ
gs-3799	22	33	,	,	PUNCT
gs-3799	22	34	or	or	CCONJ
gs-3799	22	35	systemic	systemic	ADJ
gs-3799	22	36	inflammatory	inflammatory	ADJ
gs-3799	22	37	response	response	NOUN
gs-3799	22	38	syndrome	syndrome	NOUN
gs-3799	22	39	(	(	PUNCT
gs-3799	22	40	sirs	sir	NOUN
gs-3799	22	41	)	)	PUNCT
gs-3799	22	42	.	.	PUNCT
gs-3799	23	1	these	these	DET
gs-3799	23	2	capabilities	capability	NOUN
gs-3799	23	3	are	be	AUX
gs-3799	23	4	particularly	particularly	ADV
gs-3799	23	5	valuable	valuable	ADJ
gs-3799	23	6	in	in	ADP
gs-3799	23	7	high	high	ADJ
gs-3799	23	8	-	-	PUNCT
gs-3799	23	9	risk	risk	NOUN
gs-3799	23	10	populations	population	NOUN
gs-3799	23	11	such	such	ADJ
gs-3799	23	12	as	as	ADP
gs-3799	23	13	pediatric	pediatric	ADJ
gs-3799	23	14	or	or	CCONJ
gs-3799	23	15	elderly	elderly	ADJ
gs-3799	23	16	patients	patient	NOUN
gs-3799	23	17	,	,	PUNCT
gs-3799	23	18	where	where	SCONJ
gs-3799	23	19	physiological	physiological	ADJ
gs-3799	23	20	tolerance	tolerance	NOUN
gs-3799	23	21	is	be	AUX
gs-3799	23	22	narrow	narrow	ADJ
gs-3799	23	23	.	.	PUNCT
gs-3799	24	1	recent	recent	ADJ
gs-3799	24	2	clinical	clinical	ADJ
gs-3799	24	3	and	and	CCONJ
gs-3799	24	4	experimental	experimental	ADJ
gs-3799	24	5	studies	study	NOUN
gs-3799	24	6	have	have	AUX
gs-3799	24	7	demonstrated	demonstrate	VERB
gs-3799	24	8	significant	significant	ADJ
gs-3799	24	9	benefits	benefit	NOUN
gs-3799	24	10	associated	associate	VERB
gs-3799	24	11	with	with	ADP
gs-3799	24	12	the	the	DET
gs-3799	24	13	implementation	implementation	NOUN
gs-3799	24	14	of	of	ADP
gs-3799	24	15	closed	closed	ADJ
gs-3799	24	16	-	-	PUNCT
gs-3799	24	17	loop	loop	NOUN
gs-3799	24	18	cpb	cpb	PROPN
gs-3799	24	19	systems	system	NOUN
gs-3799	24	20	.	.	PUNCT
gs-3799	25	1	these	these	PRON
gs-3799	25	2	include	include	VERB
gs-3799	25	3	improved	improve	VERB
gs-3799	25	4	intraoperative	intraoperative	ADJ
gs-3799	25	5	hemodynamic	hemodynamic	ADJ
gs-3799	25	6	control	control	NOUN
gs-3799	25	7	,	,	PUNCT
gs-3799	25	8	decreased	decrease	VERB
gs-3799	25	9	duration	duration	NOUN
gs-3799	25	10	of	of	ADP
gs-3799	25	11	bypass	bypass	NOUN
gs-3799	25	12	,	,	PUNCT
gs-3799	25	13	reduced	reduce	VERB
gs-3799	25	14	blood	blood	NOUN
gs-3799	25	15	product	product	NOUN
gs-3799	25	16	utilization	utilization	NOUN
gs-3799	25	17	,	,	PUNCT
gs-3799	25	18	lower	low	ADJ
gs-3799	25	19	postoperative	postoperative	ADJ
gs-3799	25	20	inflammatory	inflammatory	ADJ
gs-3799	25	21	markers	marker	NOUN
gs-3799	25	22	,	,	PUNCT
gs-3799	25	23	and	and	CCONJ
gs-3799	25	24	shorter	short	ADJ
gs-3799	25	25	intensive	intensive	ADJ
gs-3799	25	26	care	care	NOUN
gs-3799	25	27	unit	unit	NOUN
gs-3799	25	28	stays	stay	VERB
gs-3799	25	29	.	.	PUNCT
gs-3799	26	1	the	the	DET
gs-3799	26	2	shift	shift	NOUN
gs-3799	26	3	toward	toward	ADP
gs-3799	26	4	datadriven	datadriven	ADJ
gs-3799	26	5	,	,	PUNCT
gs-3799	26	6	patient	patient	NOUN
gs-3799	26	7	-	-	PUNCT
gs-3799	26	8	specific	specific	ADJ
gs-3799	26	9	perfusion	perfusion	NOUN
gs-3799	26	10	strategies	strategy	NOUN
gs-3799	26	11	has	have	AUX
gs-3799	26	12	also	also	ADV
gs-3799	26	13	opened	open	VERB
gs-3799	26	14	avenues	avenue	NOUN
gs-3799	26	15	for	for	ADP
gs-3799	26	16	individualized	individualized	ADJ
gs-3799	26	17	medicine	medicine	NOUN
gs-3799	26	18	,	,	PUNCT
gs-3799	26	19	enhancing	enhance	VERB
gs-3799	26	20	the	the	DET
gs-3799	26	21	safety	safety	NOUN
gs-3799	26	22	and	and	CCONJ
gs-3799	26	23	efficacy	efficacy	NOUN
gs-3799	26	24	of	of	ADP
gs-3799	26	25	cardiovascular	cardiovascular	ADJ
gs-3799	26	26	surgical	surgical	ADJ
gs-3799	26	27	procedures	procedure	NOUN
gs-3799	26	28	.	.	PUNCT
gs-3799	27	1	despite	despite	SCONJ
gs-3799	27	2	these	these	DET
gs-3799	27	3	advancements	advancement	NOUN
gs-3799	27	4	,	,	PUNCT
gs-3799	27	5	challenges	challenge	NOUN
gs-3799	27	6	remain	remain	VERB
gs-3799	27	7	in	in	ADP
gs-3799	27	8	the	the	DET
gs-3799	27	9	standardization	standardization	NOUN
gs-3799	27	10	,	,	PUNCT
gs-3799	27	11	regulatory	regulatory	ADJ
gs-3799	27	12	approval	approval	NOUN
gs-3799	27	13	,	,	PUNCT
gs-3799	27	14	and	and	CCONJ
gs-3799	27	15	integration	integration	NOUN
gs-3799	27	16	of	of	ADP
gs-3799	27	17	closed	closed	ADJ
gs-3799	27	18	-	-	PUNCT
gs-3799	27	19	loop	loop	NOUN
gs-3799	27	20	systems	system	NOUN
gs-3799	27	21	across	across	ADP
gs-3799	27	22	diverse	diverse	ADJ
gs-3799	27	23	surgical	surgical	ADJ
gs-3799	27	24	settings	setting	NOUN
gs-3799	27	25	.	.	PUNCT
gs-3799	28	1	there	there	PRON
gs-3799	28	2	is	be	VERB
gs-3799	28	3	a	a	DET
gs-3799	28	4	need	need	NOUN
gs-3799	28	5	for	for	ADP
gs-3799	28	6	multicenter	multicenter	ADJ
gs-3799	28	7	trials	trial	NOUN
gs-3799	28	8	,	,	PUNCT
gs-3799	28	9	robust	robust	ADJ
gs-3799	28	10	validation	validation	NOUN
gs-3799	28	11	protocols	protocol	NOUN
gs-3799	28	12	,	,	PUNCT
gs-3799	28	13	and	and	CCONJ
gs-3799	28	14	interdisciplinary	interdisciplinary	ADJ
gs-3799	28	15	collaboration	collaboration	NOUN
gs-3799	28	16	among	among	ADP
gs-3799	28	17	engineers	engineer	NOUN
gs-3799	28	18	,	,	PUNCT
gs-3799	28	19	perfusionists	perfusionist	NOUN
gs-3799	28	20	,	,	PUNCT
gs-3799	28	21	and	and	CCONJ
gs-3799	28	22	clinicians	clinician	NOUN
gs-3799	28	23	to	to	PART
gs-3799	28	24	refine	refine	VERB
gs-3799	28	25	algorithm	algorithm	NOUN
gs-3799	28	26	accuracy	accuracy	NOUN
gs-3799	28	27	and	and	CCONJ
gs-3799	28	28	ensure	ensure	VERB
gs-3799	28	29	clinical	clinical	ADJ
gs-3799	28	30	reliability	reliability	NOUN
gs-3799	28	31	.	.	PUNCT
gs-3799	29	1	moreover	moreover	ADV
gs-3799	29	2	,	,	PUNCT
gs-3799	29	3	the	the	DET
gs-3799	29	4	ethical	ethical	ADJ
gs-3799	29	5	and	and	CCONJ
gs-3799	29	6	logistical	logistical	ADJ
gs-3799	29	7	aspects	aspect	NOUN
gs-3799	29	8	of	of	ADP
gs-3799	29	9	autonomous	autonomous	ADJ
gs-3799	29	10	decision	decision	NOUN
gs-3799	29	11	-	-	PUNCT
gs-3799	29	12	making	making	NOUN
gs-3799	29	13	in	in	ADP
gs-3799	29	14	critical	critical	ADJ
gs-3799	29	15	care	care	NOUN
gs-3799	29	16	environments	environment	NOUN
gs-3799	29	17	must	must	AUX
gs-3799	29	18	be	be	AUX
gs-3799	29	19	carefully	carefully	ADV
gs-3799	29	20	addressed	address	VERB
gs-3799	29	21	.	.	PUNCT
gs-3799	30	1	closed	close	VERB
gs-3799	30	2	-	-	PUNCT
gs-3799	30	3	loop	loop	NOUN
gs-3799	30	4	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	30	5	bypass	bypass	NOUN
gs-3799	30	6	systems	system	NOUN
gs-3799	30	7	with	with	ADP
gs-3799	30	8	real	real	ADJ
gs-3799	30	9	-	-	PUNCT
gs-3799	30	10	time	time	NOUN
gs-3799	30	11	monitoring	monitoring	NOUN
gs-3799	30	12	and	and	CCONJ
gs-3799	30	13	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	30	14	treatment	treatment	NOUN
gs-3799	30	15	strategies	strategy	NOUN
gs-3799	30	16	represent	represent	VERB
gs-3799	30	17	a	a	DET
gs-3799	30	18	pivotal	pivotal	ADJ
gs-3799	30	19	innovation	innovation	NOUN
gs-3799	30	20	in	in	ADP
gs-3799	30	21	cardiac	cardiac	ADJ
gs-3799	30	22	surgery	surgery	NOUN
gs-3799	30	23	.	.	PUNCT
gs-3799	31	1	their	their	PRON
gs-3799	31	2	ability	ability	NOUN
gs-3799	31	3	to	to	PART
gs-3799	31	4	offer	offer	VERB
gs-3799	31	5	responsive	responsive	ADJ
gs-3799	31	6	,	,	PUNCT
gs-3799	31	7	adaptive	adaptive	ADJ
gs-3799	31	8	,	,	PUNCT
gs-3799	31	9	and	and	CCONJ
gs-3799	31	10	precise	precise	ADJ
gs-3799	31	11	management	management	NOUN
gs-3799	31	12	of	of	ADP
gs-3799	31	13	patient	patient	ADJ
gs-3799	31	14	physiology	physiology	NOUN
gs-3799	31	15	heralds	herald	VERB
gs-3799	31	16	a	a	DET
gs-3799	31	17	future	future	NOUN
gs-3799	31	18	where	where	SCONJ
gs-3799	31	19	cpb	cpb	NOUN
gs-3799	31	20	becomes	become	VERB
gs-3799	31	21	safer	safe	ADJ
gs-3799	31	22	,	,	PUNCT
gs-3799	31	23	more	more	ADV
gs-3799	31	24	efficient	efficient	ADJ
gs-3799	31	25	,	,	PUNCT
gs-3799	31	26	and	and	CCONJ
gs-3799	31	27	increasingly	increasingly	ADV
gs-3799	31	28	personalized	personalize	VERB
gs-3799	31	29	.	.	PUNCT
gs-3799	32	1	ongoing	ongoing	ADJ
gs-3799	32	2	research	research	NOUN
gs-3799	32	3	and	and	CCONJ
gs-3799	32	4	development	development	NOUN
gs-3799	32	5	will	will	AUX
gs-3799	32	6	further	far	ADV
gs-3799	32	7	enhance	enhance	VERB
gs-3799	32	8	these	these	DET
gs-3799	32	9	systems	system	NOUN
gs-3799	32	10	,	,	PUNCT
gs-3799	32	11	positioning	position	VERB
gs-3799	32	12	them	they	PRON
gs-3799	32	13	at	at	ADP
gs-3799	32	14	the	the	DET
gs-3799	32	15	forefront	forefront	NOUN
gs-3799	32	16	of	of	ADP
gs-3799	32	17	technological	technological	ADJ
gs-3799	32	18	progress	progress	NOUN
gs-3799	32	19	in	in	ADP
gs-3799	32	20	cardiovascular	cardiovascular	ADJ
gs-3799	32	21	medicine	medicine	NOUN
gs-3799	32	22	.	.	PUNCT
gs-3799	33	1	georgian	georgian	NOUN
gs-3799	33	2	scientists/	scientists/	NUM
gs-3799	33	3	.	.	PUNCT
gs-3799	34	1	7	7	NUM
gs-3799	34	2	n	n	DET
gs-3799	34	3	2	2	NUM
gs-3799	34	4	,	,	PUNCT
gs-3799	34	5	2025	2025	NUM
gs-3799	34	6	383	383	NUM
gs-3799	34	7	keywords	keyword	NOUN
gs-3799	34	8	:	:	PUNCT
gs-3799	34	9	closed	closed	ADJ
gs-3799	34	10	-	-	PUNCT
gs-3799	34	11	loop	loop	NOUN
gs-3799	34	12	,	,	PUNCT
gs-3799	34	13	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	34	14	bypass	bypass	NOUN
gs-3799	34	15	,	,	PUNCT
gs-3799	34	16	real	real	ADJ
gs-3799	34	17	-	-	PUNCT
gs-3799	34	18	time	time	NOUN
gs-3799	34	19	monitoring	monitoring	NOUN
gs-3799	34	20	,	,	PUNCT
gs-3799	34	21	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	34	22	,	,	PUNCT
gs-3799	34	23	perfusion	perfusion	NOUN
gs-3799	34	24	control	control	NOUN
gs-3799	34	25	,	,	PUNCT
gs-3799	34	26	hemodynamic	hemodynamic	ADJ
gs-3799	34	27	stability	stability	NOUN
gs-3799	34	28	,	,	PUNCT
gs-3799	34	29	smart	smart	ADJ
gs-3799	34	30	drug	drug	NOUN
gs-3799	34	31	delivery	delivery	NOUN
gs-3799	34	32	,	,	PUNCT
gs-3799	34	33	automated	automated	ADJ
gs-3799	34	34	cpb	cpb	PROPN
gs-3799	34	35	.	.	PROPN
gs-3799	35	1	introduction	introduction	NOUN
gs-3799	35	2	cardiopulmonary	cardiopulmonary	PROPN
gs-3799	35	3	bypass	bypass	NOUN
gs-3799	35	4	(	(	PUNCT
gs-3799	35	5	cpb	cpb	NOUN
gs-3799	35	6	)	)	PUNCT
gs-3799	35	7	remains	remain	VERB
gs-3799	35	8	a	a	DET
gs-3799	35	9	cornerstone	cornerstone	NOUN
gs-3799	35	10	technology	technology	NOUN
gs-3799	35	11	enabling	enable	VERB
gs-3799	35	12	life	life	NOUN
gs-3799	35	13	-	-	PUNCT
gs-3799	35	14	saving	save	VERB
gs-3799	35	15	openheart	openheart	NOUN
gs-3799	35	16	surgery	surgery	NOUN
gs-3799	35	17	,	,	PUNCT
gs-3799	35	18	providing	provide	VERB
gs-3799	35	19	temporary	temporary	ADJ
gs-3799	35	20	circulatory	circulatory	ADJ
gs-3799	35	21	and	and	CCONJ
gs-3799	35	22	respiratory	respiratory	ADJ
gs-3799	35	23	support	support	NOUN
gs-3799	35	24	while	while	SCONJ
gs-3799	35	25	the	the	DET
gs-3799	35	26	heart	heart	NOUN
gs-3799	35	27	is	be	AUX
gs-3799	35	28	arrested	arrest	VERB
gs-3799	35	29	.	.	PUNCT
gs-3799	36	1	despite	despite	SCONJ
gs-3799	36	2	decades	decade	NOUN
gs-3799	36	3	of	of	ADP
gs-3799	36	4	refinement	refinement	NOUN
gs-3799	36	5	,	,	PUNCT
gs-3799	36	6	conventional	conventional	ADJ
gs-3799	36	7	cpb	cpb	PROPN
gs-3799	36	8	management	management	NOUN
gs-3799	36	9	relies	rely	VERB
gs-3799	36	10	heavily	heavily	ADV
gs-3799	36	11	on	on	ADP
gs-3799	36	12	manual	manual	ADJ
gs-3799	36	13	operation	operation	NOUN
gs-3799	36	14	by	by	ADP
gs-3799	36	15	perfusionists	perfusionist	NOUN
gs-3799	36	16	,	,	PUNCT
gs-3799	36	17	requiring	require	VERB
gs-3799	36	18	continuous	continuous	ADJ
gs-3799	36	19	vigilance	vigilance	NOUN
gs-3799	36	20	and	and	CCONJ
gs-3799	36	21	rapid	rapid	ADJ
gs-3799	36	22	intervention	intervention	NOUN
gs-3799	36	23	to	to	PART
gs-3799	36	24	maintain	maintain	VERB
gs-3799	36	25	hemodynamic	hemodynamic	ADJ
gs-3799	36	26	stability	stability	NOUN
gs-3799	36	27	,	,	PUNCT
gs-3799	36	28	anticoagulation	anticoagulation	NOUN
gs-3799	36	29	,	,	PUNCT
gs-3799	36	30	gas	gas	NOUN
gs-3799	36	31	exchange	exchange	NOUN
gs-3799	36	32	,	,	PUNCT
gs-3799	36	33	and	and	CCONJ
gs-3799	36	34	organ	organ	NOUN
gs-3799	36	35	perfusion	perfusion	NOUN
gs-3799	36	36	.	.	PUNCT
gs-3799	37	1	this	this	DET
gs-3799	37	2	open	open	ADJ
gs-3799	37	3	-	-	PUNCT
gs-3799	37	4	loop	loop	NOUN
gs-3799	37	5	approach	approach	NOUN
gs-3799	37	6	is	be	AUX
gs-3799	37	7	inherently	inherently	ADV
gs-3799	37	8	susceptible	susceptible	ADJ
gs-3799	37	9	to	to	ADP
gs-3799	37	10	human	human	ADJ
gs-3799	37	11	error	error	NOUN
gs-3799	37	12	,	,	PUNCT
gs-3799	37	13	cognitive	cognitive	ADJ
gs-3799	37	14	overload	overload	NOUN
gs-3799	37	15	,	,	PUNCT
gs-3799	37	16	and	and	CCONJ
gs-3799	37	17	delayed	delay	VERB
gs-3799	37	18	responses	response	NOUN
gs-3799	37	19	to	to	ADP
gs-3799	37	20	dynamic	dynamic	ADJ
gs-3799	37	21	physiological	physiological	ADJ
gs-3799	37	22	changes	change	NOUN
gs-3799	37	23	,	,	PUNCT
gs-3799	37	24	contributing	contribute	VERB
gs-3799	37	25	to	to	ADP
gs-3799	37	26	significant	significant	ADJ
gs-3799	37	27	perioperative	perioperative	ADJ
gs-3799	37	28	risks	risk	NOUN
gs-3799	37	29	.	.	PUNCT
gs-3799	38	1	these	these	PRON
gs-3799	38	2	include	include	VERB
gs-3799	38	3	hemodynamic	hemodynamic	ADJ
gs-3799	38	4	instability	instability	NOUN
gs-3799	38	5	,	,	PUNCT
gs-3799	38	6	coagulopathies	coagulopathie	NOUN
gs-3799	38	7	(	(	PUNCT
gs-3799	38	8	thrombosis	thrombosis	NOUN
gs-3799	38	9	or	or	CCONJ
gs-3799	38	10	hemorrhage	hemorrhage	NOUN
gs-3799	38	11	)	)	PUNCT
gs-3799	38	12	,	,	PUNCT
gs-3799	38	13	systemic	systemic	ADJ
gs-3799	38	14	inflammatory	inflammatory	ADJ
gs-3799	38	15	response	response	NOUN
gs-3799	38	16	syndrome	syndrome	NOUN
gs-3799	38	17	(	(	PUNCT
gs-3799	38	18	sirs	sirs	PROPN
gs-3799	38	19	)	)	PUNCT
gs-3799	38	20	,	,	PUNCT
gs-3799	38	21	endorgan	endorgan	VERB
gs-3799	38	22	dysfunction	dysfunction	NOUN
gs-3799	38	23	(	(	PUNCT
gs-3799	38	24	e.g.	e.g.	ADV
gs-3799	38	25	,	,	PUNCT
gs-3799	38	26	renal	renal	ADJ
gs-3799	38	27	,	,	PUNCT
gs-3799	38	28	neurological	neurological	ADJ
gs-3799	38	29	)	)	PUNCT
gs-3799	38	30	,	,	PUNCT
gs-3799	38	31	and	and	CCONJ
gs-3799	38	32	extended	extend	VERB
gs-3799	38	33	intensive	intensive	ADJ
gs-3799	38	34	care	care	NOUN
gs-3799	38	35	unit	unit	NOUN
gs-3799	38	36	(	(	PUNCT
gs-3799	38	37	icu	icu	PROPN
gs-3799	38	38	)	)	PUNCT
gs-3799	38	39	stays	stay	NOUN
gs-3799	38	40	.	.	PUNCT
gs-3799	39	1	the	the	DET
gs-3799	39	2	integration	integration	NOUN
gs-3799	39	3	of	of	ADP
gs-3799	39	4	real	real	ADJ
gs-3799	39	5	-	-	PUNCT
gs-3799	39	6	time	time	NOUN
gs-3799	39	7	physiological	physiological	ADJ
gs-3799	39	8	monitoring	monitoring	NOUN
gs-3799	39	9	(	(	PUNCT
gs-3799	39	10	e.g.	e.g.	ADV
gs-3799	39	11	,	,	PUNCT
gs-3799	39	12	continuous	continuous	ADJ
gs-3799	39	13	blood	blood	NOUN
gs-3799	39	14	gas	gas	NOUN
gs-3799	39	15	analysis	analysis	NOUN
gs-3799	39	16	,	,	PUNCT
gs-3799	39	17	pressure	pressure	NOUN
gs-3799	39	18	/	/	SYM
gs-3799	39	19	flow	flow	NOUN
gs-3799	39	20	sensors	sensor	NOUN
gs-3799	39	21	,	,	PUNCT
gs-3799	39	22	biochemical	biochemical	ADJ
gs-3799	39	23	markers	marker	NOUN
gs-3799	39	24	)	)	PUNCT
gs-3799	39	25	with	with	ADP
gs-3799	39	26	closed	close	VERB
gs-3799	39	27	-	-	PUNCT
gs-3799	39	28	loop	loop	NOUN
gs-3799	39	29	control	control	NOUN
gs-3799	39	30	algorithms	algorithm	NOUN
gs-3799	39	31	represents	represent	VERB
gs-3799	39	32	a	a	DET
gs-3799	39	33	paradigm	paradigm	NOUN
gs-3799	39	34	shift	shift	NOUN
gs-3799	39	35	towards	towards	ADP
gs-3799	39	36	intelligent	intelligent	ADJ
gs-3799	39	37	,	,	PUNCT
gs-3799	39	38	automated	automate	VERB
gs-3799	39	39	perfusion	perfusion	NOUN
gs-3799	39	40	systems	system	NOUN
gs-3799	39	41	.	.	PUNCT
gs-3799	40	1	these	these	DET
gs-3799	40	2	advanced	advanced	ADJ
gs-3799	40	3	systems	system	NOUN
gs-3799	40	4	dynamically	dynamically	ADV
gs-3799	40	5	adjust	adjust	VERB
gs-3799	40	6	critical	critical	ADJ
gs-3799	40	7	parameters	parameter	NOUN
gs-3799	40	8	–	–	PUNCT
gs-3799	40	9	such	such	ADJ
gs-3799	40	10	as	as	ADP
gs-3799	40	11	pump	pump	NOUN
gs-3799	40	12	flow	flow	NOUN
gs-3799	40	13	,	,	PUNCT
gs-3799	40	14	arterial	arterial	ADJ
gs-3799	40	15	pressure	pressure	NOUN
gs-3799	40	16	,	,	PUNCT
gs-3799	40	17	oxygen	oxygen	NOUN
gs-3799	40	18	delivery	delivery	NOUN
gs-3799	40	19	,	,	PUNCT
gs-3799	40	20	and	and	CCONJ
gs-3799	40	21	crucially	crucially	ADV
gs-3799	40	22	,	,	PUNCT
gs-3799	40	23	targeted	target	VERB
gs-3799	40	24	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	40	25	administration	administration	NOUN
gs-3799	40	26	(	(	PUNCT
gs-3799	40	27	e.g.	e.g.	ADV
gs-3799	40	28	,	,	PUNCT
gs-3799	40	29	heparin	heparin	ADJ
gs-3799	40	30	/	/	SYM
gs-3799	40	31	protamine	protamine	NOUN
gs-3799	40	32	for	for	ADP
gs-3799	40	33	anticoagulation	anticoagulation	NOUN
gs-3799	40	34	,	,	PUNCT
gs-3799	40	35	vasoactive	vasoactive	ADJ
gs-3799	40	36	drugs	drug	NOUN
gs-3799	40	37	,	,	PUNCT
gs-3799	40	38	antiinflammatory	antiinflammatory	NOUN
gs-3799	40	39	agents	agent	NOUN
gs-3799	40	40	)	)	PUNCT
gs-3799	40	41	–	–	PUNCT
gs-3799	40	42	based	base	VERB
gs-3799	40	43	on	on	ADP
gs-3799	40	44	continuous	continuous	ADJ
gs-3799	40	45	sensor	sensor	NOUN
gs-3799	40	46	feedback	feedback	NOUN
gs-3799	40	47	.	.	PUNCT
gs-3799	41	1	this	this	DET
gs-3799	41	2	closed	close	VERB
gs-3799	41	3	-	-	PUNCT
gs-3799	41	4	loop	loop	NOUN
gs-3799	41	5	approach	approach	NOUN
gs-3799	41	6	promises	promise	VERB
gs-3799	41	7	enhanced	enhanced	ADJ
gs-3799	41	8	precision	precision	NOUN
gs-3799	41	9	,	,	PUNCT
gs-3799	41	10	reduced	reduce	VERB
gs-3799	41	11	human	human	ADJ
gs-3799	41	12	error	error	NOUN
gs-3799	41	13	burden	burden	NOUN
gs-3799	41	14	,	,	PUNCT
gs-3799	41	15	improved	improve	VERB
gs-3799	41	16	physiological	physiological	ADJ
gs-3799	41	17	stability	stability	NOUN
gs-3799	41	18	,	,	PUNCT
gs-3799	41	19	and	and	CCONJ
gs-3799	41	20	ultimately	ultimately	ADV
gs-3799	41	21	,	,	PUNCT
gs-3799	41	22	superior	superior	ADJ
gs-3799	41	23	patient	patient	ADJ
gs-3799	41	24	outcomes	outcome	NOUN
gs-3799	41	25	.	.	PUNCT
gs-3799	42	1	however	however	ADV
gs-3799	42	2	,	,	PUNCT
gs-3799	42	3	the	the	DET
gs-3799	42	4	field	field	NOUN
gs-3799	42	5	of	of	ADP
gs-3799	42	6	closed	closed	ADJ
gs-3799	42	7	-	-	PUNCT
gs-3799	42	8	loop	loop	NOUN
gs-3799	42	9	cpb	cpb	NOUN
gs-3799	42	10	is	be	AUX
gs-3799	42	11	rapidly	rapidly	ADV
gs-3799	42	12	evolving	evolve	VERB
gs-3799	42	13	with	with	ADP
gs-3799	42	14	diverse	diverse	ADJ
gs-3799	42	15	technological	technological	ADJ
gs-3799	42	16	implementations	implementation	NOUN
gs-3799	42	17	.	.	PUNCT
gs-3799	43	1	key	key	ADJ
gs-3799	43	2	innovations	innovation	NOUN
gs-3799	43	3	span	span	VERB
gs-3799	43	4	advanced	advanced	ADJ
gs-3799	43	5	sensor	sensor	NOUN
gs-3799	43	6	technologies	technology	NOUN
gs-3799	43	7	(	(	PUNCT
gs-3799	43	8	optical	optical	ADJ
gs-3799	43	9	,	,	PUNCT
gs-3799	43	10	electrochemical	electrochemical	ADJ
gs-3799	43	11	)	)	PUNCT
gs-3799	43	12	,	,	PUNCT
gs-3799	43	13	robust	robust	ADJ
gs-3799	43	14	control	control	NOUN
gs-3799	43	15	algorithms	algorithm	NOUN
gs-3799	43	16	(	(	PUNCT
gs-3799	43	17	pid	pid	NOUN
gs-3799	43	18	,	,	PUNCT
gs-3799	43	19	fuzzy	fuzzy	ADJ
gs-3799	43	20	logic	logic	NOUN
gs-3799	43	21	,	,	PUNCT
gs-3799	43	22	model	model	ADJ
gs-3799	43	23	-	-	PUNCT
gs-3799	43	24	predictive	predictive	ADJ
gs-3799	43	25	control	control	NOUN
gs-3799	43	26	,	,	PUNCT
gs-3799	43	27	increasingly	increasingly	ADV
gs-3799	43	28	incorporating	incorporate	VERB
gs-3799	43	29	ai	ai	NOUN
gs-3799	43	30	/	/	SYM
gs-3799	43	31	ml	ml	NOUN
gs-3799	43	32	)	)	PUNCT
gs-3799	43	33	,	,	PUNCT
gs-3799	43	34	seamless	seamless	ADJ
gs-3799	43	35	human	human	NOUN
gs-3799	43	36	-	-	PUNCT
gs-3799	43	37	machine	machine	NOUN
gs-3799	43	38	interfaces	interface	NOUN
gs-3799	43	39	,	,	PUNCT
gs-3799	43	40	and	and	CCONJ
gs-3799	43	41	sophisticated	sophisticated	ADJ
gs-3799	43	42	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	43	43	integration	integration	NOUN
gs-3799	43	44	strategies	strategy	NOUN
gs-3799	43	45	.	.	PUNCT
gs-3799	44	1	while	while	SCONJ
gs-3799	44	2	promising	promise	VERB
gs-3799	44	3	,	,	PUNCT
gs-3799	44	4	the	the	DET
gs-3799	44	5	evidence	evidence	NOUN
gs-3799	44	6	base	base	NOUN
gs-3799	44	7	for	for	ADP
gs-3799	44	8	these	these	DET
gs-3799	44	9	systems	system	NOUN
gs-3799	44	10	remains	remain	VERB
gs-3799	44	11	fragmented	fragmented	ADJ
gs-3799	44	12	.	.	PUNCT
gs-3799	45	1	comprehensive	comprehensive	ADJ
gs-3799	45	2	analyses	analysis	NOUN
gs-3799	45	3	characterizing	characterize	VERB
gs-3799	45	4	their	their	PRON
gs-3799	45	5	core	core	ADJ
gs-3799	45	6	technological	technological	ADJ
gs-3799	45	7	features	feature	NOUN
gs-3799	45	8	,	,	PUNCT
gs-3799	45	9	rigorously	rigorously	ADV
gs-3799	45	10	evaluating	evaluate	VERB
gs-3799	45	11	the	the	DET
gs-3799	45	12	efficacy	efficacy	NOUN
gs-3799	45	13	and	and	CCONJ
gs-3799	45	14	safety	safety	NOUN
gs-3799	45	15	of	of	ADP
gs-3799	45	16	integrated	integrate	VERB
gs-3799	45	17	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	45	18	protocols	protocol	NOUN
gs-3799	45	19	,	,	PUNCT
gs-3799	45	20	quantifying	quantify	VERB
gs-3799	45	21	their	their	PRON
gs-3799	45	22	comparative	comparative	ADJ
gs-3799	45	23	clinical	clinical	ADJ
gs-3799	45	24	and	and	CCONJ
gs-3799	45	25	operational	operational	ADJ
gs-3799	45	26	outcomes	outcome	NOUN
gs-3799	45	27	against	against	ADP
gs-3799	45	28	conventional	conventional	ADJ
gs-3799	45	29	cpb	cpb	NOUN
gs-3799	45	30	,	,	PUNCT
gs-3799	45	31	and	and	CCONJ
gs-3799	45	32	critically	critically	ADV
gs-3799	45	33	assessing	assess	VERB
gs-3799	45	34	their	their	PRON
gs-3799	45	35	broader	broad	ADJ
gs-3799	45	36	impact	impact	NOUN
gs-3799	45	37	on	on	ADP
gs-3799	45	38	workflow	workflow	NOUN
gs-3799	45	39	and	and	CCONJ
gs-3799	45	40	safety	safety	NOUN
gs-3799	45	41	are	be	AUX
gs-3799	45	42	lacking	lack	VERB
gs-3799	45	43	.	.	PUNCT
gs-3799	46	1	furthermore	furthermore	ADV
gs-3799	46	2	,	,	PUNCT
gs-3799	46	3	a	a	DET
gs-3799	46	4	clear	clear	ADJ
gs-3799	46	5	synthesis	synthesis	NOUN
gs-3799	46	6	of	of	ADP
gs-3799	46	7	innovations	innovation	NOUN
gs-3799	46	8	and	and	CCONJ
gs-3799	46	9	a	a	DET
gs-3799	46	10	consensus	consensus	NOUN
gs-3799	46	11	-	-	PUNCT
gs-3799	46	12	driven	drive	VERB
gs-3799	46	13	roadmap	roadmap	NOUN
gs-3799	46	14	for	for	ADP
gs-3799	46	15	future	future	ADJ
gs-3799	46	16	development	development	NOUN
gs-3799	46	17	are	be	AUX
gs-3799	46	18	urgently	urgently	ADV
gs-3799	46	19	needed	need	VERB
gs-3799	46	20	to	to	PART
gs-3799	46	21	guide	guide	VERB
gs-3799	46	22	research	research	NOUN
gs-3799	46	23	,	,	PUNCT
gs-3799	46	24	investment	investment	NOUN
gs-3799	46	25	,	,	PUNCT
gs-3799	46	26	and	and	CCONJ
gs-3799	46	27	clinical	clinical	ADJ
gs-3799	46	28	adoption	adoption	NOUN
gs-3799	46	29	.	.	PUNCT
gs-3799	47	1	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	47	2	bypass	bypass	NOUN
gs-3799	47	3	(	(	PUNCT
gs-3799	47	4	cpb	cpb	NOUN
gs-3799	47	5	)	)	PUNCT
gs-3799	47	6	is	be	AUX
gs-3799	47	7	a	a	DET
gs-3799	47	8	vital	vital	ADJ
gs-3799	47	9	component	component	NOUN
gs-3799	47	10	in	in	ADP
gs-3799	47	11	pediatric	pediatric	ADJ
gs-3799	47	12	cardiac	cardiac	ADJ
gs-3799	47	13	surgery	surgery	NOUN
gs-3799	47	14	,	,	PUNCT
gs-3799	47	15	however	however	ADV
gs-3799	47	16	,	,	PUNCT
gs-3799	47	17	numerous	numerous	ADJ
gs-3799	47	18	obstacles	obstacle	NOUN
gs-3799	47	19	are	be	AUX
gs-3799	47	20	presented	present	VERB
gs-3799	47	21	due	due	ADP
gs-3799	47	22	to	to	ADP
gs-3799	47	23	the	the	DET
gs-3799	47	24	immature	immature	ADJ
gs-3799	47	25	and	and	CCONJ
gs-3799	47	26	delicate	delicate	ADJ
gs-3799	47	27	physiology	physiology	NOUN
gs-3799	47	28	of	of	ADP
gs-3799	47	29	neonates	neonate	NOUN
gs-3799	47	30	and	and	CCONJ
gs-3799	47	31	infants	infant	NOUN
gs-3799	47	32	.	.	PUNCT
gs-3799	48	1	commonly	commonly	ADV
gs-3799	48	2	used	use	VERB
gs-3799	48	3	open	open	ADJ
gs-3799	48	4	-	-	PUNCT
gs-3799	48	5	loop	loop	NOUN
gs-3799	48	6	cpb	cpb	NOUN
gs-3799	48	7	systems	system	NOUN
gs-3799	48	8	are	be	AUX
gs-3799	48	9	no	no	ADV
gs-3799	48	10	longer	long	ADV
gs-3799	48	11	ideal	ideal	ADJ
gs-3799	48	12	due	due	ADP
gs-3799	48	13	to	to	ADP
gs-3799	48	14	the	the	DET
gs-3799	48	15	requirement	requirement	NOUN
gs-3799	48	16	of	of	ADP
gs-3799	48	17	manual	manual	ADJ
gs-3799	48	18	adjustments	adjustment	NOUN
gs-3799	48	19	,	,	PUNCT
gs-3799	48	20	along	along	ADP
gs-3799	48	21	with	with	ADP
gs-3799	48	22	the	the	DET
gs-3799	48	23	lack	lack	NOUN
gs-3799	48	24	of	of	ADP
gs-3799	48	25	reliability	reliability	NOUN
gs-3799	48	26	and	and	CCONJ
gs-3799	48	27	being	be	AUX
gs-3799	48	28	prone	prone	ADJ
gs-3799	48	29	to	to	ADP
gs-3799	48	30	human	human	ADJ
gs-3799	48	31	error	error	NOUN
gs-3799	48	32	.	.	PUNCT
gs-3799	49	1	closed	close	VERB
gs-3799	49	2	-	-	PUNCT
gs-3799	49	3	loop	loop	NOUN
gs-3799	49	4	systems	system	NOUN
gs-3799	49	5	embody	embody	VERB
gs-3799	49	6	real	real	ADJ
gs-3799	49	7	-	-	PUNCT
gs-3799	49	8	time	time	NOUN
gs-3799	49	9	monitoring	monitoring	NOUN
gs-3799	49	10	and	and	CCONJ
gs-3799	49	11	automatic	automatic	ADJ
gs-3799	49	12	control	control	NOUN
gs-3799	49	13	,	,	PUNCT
gs-3799	49	14	enabling	enable	VERB
gs-3799	49	15	a	a	DET
gs-3799	49	16	potential	potential	ADJ
gs-3799	49	17	advancement	advancement	NOUN
gs-3799	49	18	.	.	PUNCT
gs-3799	50	1	this	this	DET
gs-3799	50	2	review	review	NOUN
gs-3799	50	3	assesses	assess	VERB
gs-3799	50	4	innovative	innovative	ADJ
gs-3799	50	5	designs	design	NOUN
gs-3799	50	6	,	,	PUNCT
gs-3799	50	7	including	include	VERB
gs-3799	50	8	near	near	ADV
gs-3799	50	9	-	-	PUNCT
gs-3799	50	10	infrared	infrared	ADJ
gs-3799	50	11	spectroscopy	spectroscopy	NOUN
gs-3799	50	12	(	(	PUNCT
gs-3799	50	13	nirs	nirs	PROPN
gs-3799	50	14	)	)	PUNCT
gs-3799	50	15	,	,	PUNCT
gs-3799	50	16	continuous	continuous	ADJ
gs-3799	50	17	svo	svo	NOUN
gs-3799	50	18	monitoring	monitoring	NOUN
gs-3799	50	19	,	,	PUNCT
gs-3799	50	20	and	and	CCONJ
gs-3799	50	21	adaptive	adaptive	ADJ
gs-3799	50	22	perfusion	perfusion	NOUN
gs-3799	50	23	algorithms	algorithm	NOUN
gs-3799	50	24	.	.	PUNCT
gs-3799	51	1	key	key	ADJ
gs-3799	51	2	findings	finding	NOUN
gs-3799	51	3	propose	propose	VERB
gs-3799	51	4	refinements	refinement	NOUN
gs-3799	51	5	in	in	ADP
gs-3799	51	6	areas	area	NOUN
gs-3799	51	7	such	such	ADJ
gs-3799	51	8	as	as	ADP
gs-3799	51	9	hemodynamic	hemodynamic	ADJ
gs-3799	51	10	stability	stability	NOUN
gs-3799	51	11	,	,	PUNCT
gs-3799	51	12	perfusion	perfusion	NOUN
gs-3799	51	13	accuracy	accuracy	NOUN
gs-3799	51	14	,	,	PUNCT
gs-3799	51	15	and	and	CCONJ
gs-3799	51	16	reaction	reaction	NOUN
gs-3799	51	17	times	time	NOUN
gs-3799	51	18	during	during	ADP
gs-3799	51	19	surgery	surgery	NOUN
gs-3799	51	20	.	.	PUNCT
gs-3799	52	1	challenges	challenge	NOUN
gs-3799	52	2	including	include	VERB
gs-3799	52	3	expenses	expense	NOUN
gs-3799	52	4	,	,	PUNCT
gs-3799	52	5	the	the	DET
gs-3799	52	6	development	development	NOUN
gs-3799	52	7	of	of	ADP
gs-3799	52	8	an	an	DET
gs-3799	52	9	intricate	intricate	ADJ
gs-3799	52	10	system	system	NOUN
gs-3799	52	11	,	,	PUNCT
gs-3799	52	12	and	and	CCONJ
gs-3799	52	13	ethical	ethical	ADJ
gs-3799	52	14	dilemmas	dilemma	NOUN
gs-3799	52	15	are	be	AUX
gs-3799	52	16	of	of	ADP
gs-3799	52	17	primary	primary	ADJ
gs-3799	52	18	concern	concern	NOUN
gs-3799	52	19	.	.	PUNCT
gs-3799	53	1	future	future	ADJ
gs-3799	53	2	directions	direction	NOUN
gs-3799	53	3	consist	consist	VERB
gs-3799	53	4	of	of	ADP
gs-3799	53	5	establishing	establish	VERB
gs-3799	53	6	an	an	DET
gs-3799	53	7	algorithm	algorithm	NOUN
gs-3799	53	8	distinctly	distinctly	ADV
gs-3799	53	9	for	for	ADP
gs-3799	53	10	pediatric	pediatric	ADJ
gs-3799	53	11	patients	patient	NOUN
gs-3799	53	12	,	,	PUNCT
gs-3799	53	13	collaborating	collaborate	VERB
gs-3799	53	14	with	with	ADP
gs-3799	53	15	georgian	georgian	PROPN
gs-3799	53	16	scientists/	scientists/	NUM
gs-3799	53	17	.	.	PUNCT
gs-3799	54	1	7	7	NUM
gs-3799	54	2	n	n	PRON
gs-3799	54	3	2	2	NUM
gs-3799	54	4	,	,	PUNCT
gs-3799	54	5	2025	2025	NUM
gs-3799	54	6	384	384	NUM
gs-3799	54	7	diverse	diverse	ADJ
gs-3799	54	8	fields	field	NOUN
gs-3799	54	9	,	,	PUNCT
gs-3799	54	10	and	and	CCONJ
gs-3799	54	11	combining	combine	VERB
gs-3799	54	12	various	various	ADJ
gs-3799	54	13	control	control	NOUN
gs-3799	54	14	prototypes	prototype	NOUN
gs-3799	54	15	.	.	PUNCT
gs-3799	55	1	closed	close	VERB
gs-3799	55	2	-	-	PUNCT
gs-3799	55	3	loop	loop	NOUN
gs-3799	55	4	cpb	cpb	NOUN
gs-3799	55	5	gives	give	VERB
gs-3799	55	6	hope	hope	NOUN
gs-3799	55	7	for	for	ADP
gs-3799	55	8	a	a	DET
gs-3799	55	9	future	future	NOUN
gs-3799	55	10	where	where	SCONJ
gs-3799	55	11	we	we	PRON
gs-3799	55	12	can	can	AUX
gs-3799	55	13	enhance	enhance	VERB
gs-3799	55	14	safety	safety	NOUN
gs-3799	55	15	and	and	CCONJ
gs-3799	55	16	competency	competency	NOUN
gs-3799	55	17	in	in	ADP
gs-3799	55	18	pediatric	pediatric	ADJ
gs-3799	55	19	cardiac	cardiac	ADJ
gs-3799	55	20	surgery	surgery	NOUN
gs-3799	55	21	.	.	PUNCT
gs-3799	56	1	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	56	2	bypass	bypass	NOUN
gs-3799	56	3	(	(	PUNCT
gs-3799	56	4	cpb	cpb	PROPN
gs-3799	56	5	)	)	PUNCT
gs-3799	56	6	,	,	PUNCT
gs-3799	56	7	first	first	ADV
gs-3799	56	8	utilized	utilize	VERB
gs-3799	56	9	by	by	ADP
gs-3799	56	10	john	john	PROPN
gs-3799	56	11	gibbon	gibbon	PROPN
gs-3799	56	12	on	on	ADP
gs-3799	56	13	may	may	PROPN
gs-3799	56	14	6	6	NUM
gs-3799	56	15	,	,	PUNCT
gs-3799	56	16	1953	1953	NUM
gs-3799	56	17	,	,	PUNCT
gs-3799	56	18	was	be	AUX
gs-3799	56	19	a	a	DET
gs-3799	56	20	revolutionary	revolutionary	ADJ
gs-3799	56	21	breakthrough	breakthrough	NOUN
gs-3799	56	22	in	in	ADP
gs-3799	56	23	the	the	DET
gs-3799	56	24	field	field	NOUN
gs-3799	56	25	of	of	ADP
gs-3799	56	26	cardiac	cardiac	ADJ
gs-3799	56	27	surgery	surgery	NOUN
gs-3799	56	28	and	and	CCONJ
gs-3799	56	29	has	have	AUX
gs-3799	56	30	now	now	ADV
gs-3799	56	31	become	become	VERB
gs-3799	56	32	an	an	DET
gs-3799	56	33	imperative	imperative	ADJ
gs-3799	56	34	piece	piece	NOUN
gs-3799	56	35	of	of	ADP
gs-3799	56	36	technology	technology	NOUN
gs-3799	56	37	during	during	ADP
gs-3799	56	38	open	open	ADJ
gs-3799	56	39	heart	heart	NOUN
gs-3799	56	40	surgery	surgery	NOUN
gs-3799	56	41	.	.	PUNCT
gs-3799	57	1	to	to	PART
gs-3799	57	2	perform	perform	VERB
gs-3799	57	3	meticulous	meticulous	ADJ
gs-3799	57	4	reconstructive	reconstructive	ADJ
gs-3799	57	5	procedures	procedure	NOUN
gs-3799	57	6	on	on	ADP
gs-3799	57	7	the	the	DET
gs-3799	57	8	heart	heart	NOUN
gs-3799	57	9	,	,	PUNCT
gs-3799	57	10	whilst	whilst	SCONJ
gs-3799	57	11	maintaining	maintain	VERB
gs-3799	57	12	circulation	circulation	NOUN
gs-3799	57	13	throughout	throughout	ADP
gs-3799	57	14	the	the	DET
gs-3799	57	15	body	body	NOUN
gs-3799	57	16	,	,	PUNCT
gs-3799	57	17	cpb	cpb	PROPN
gs-3799	57	18	assumes	assume	VERB
gs-3799	57	19	the	the	DET
gs-3799	57	20	role	role	NOUN
gs-3799	57	21	of	of	ADP
gs-3799	57	22	impermanent	impermanent	NOUN
gs-3799	57	23	replacing	replace	VERB
gs-3799	57	24	cardiac	cardiac	ADJ
gs-3799	57	25	and	and	CCONJ
gs-3799	57	26	pulmonary	pulmonary	ADJ
gs-3799	57	27	function	function	NOUN
gs-3799	57	28	during	during	ADP
gs-3799	57	29	surgery	surgery	NOUN
gs-3799	57	30	.	.	PUNCT
gs-3799	58	1	however	however	ADV
gs-3799	58	2	,	,	PUNCT
gs-3799	58	3	the	the	DET
gs-3799	58	4	physiological	physiological	ADJ
gs-3799	58	5	makeup	makeup	NOUN
gs-3799	58	6	of	of	ADP
gs-3799	58	7	neonates	neonate	NOUN
gs-3799	58	8	and	and	CCONJ
gs-3799	58	9	infants	infant	NOUN
gs-3799	58	10	,	,	PUNCT
gs-3799	58	11	such	such	ADJ
gs-3799	58	12	as	as	ADP
gs-3799	58	13	their	their	PRON
gs-3799	58	14	frailty	frailty	NOUN
gs-3799	58	15	,	,	PUNCT
gs-3799	58	16	small	small	ADJ
gs-3799	58	17	blood	blood	NOUN
gs-3799	58	18	volumes	volume	NOUN
gs-3799	58	19	and	and	CCONJ
gs-3799	58	20	profound	profound	ADJ
gs-3799	58	21	sensitivity	sensitivity	NOUN
gs-3799	58	22	to	to	PART
gs-3799	58	23	perfusion	perfusion	NOUN
gs-3799	58	24	fluctuations	fluctuation	NOUN
gs-3799	58	25	,	,	PUNCT
gs-3799	58	26	leaves	leave	VERB
gs-3799	58	27	us	we	PRON
gs-3799	58	28	with	with	ADP
gs-3799	58	29	a	a	DET
gs-3799	58	30	narrow	narrow	ADJ
gs-3799	58	31	margin	margin	NOUN
gs-3799	58	32	for	for	ADP
gs-3799	58	33	error	error	NOUN
gs-3799	58	34	.	.	PUNCT
gs-3799	59	1	an	an	DET
gs-3799	59	2	open	open	ADJ
gs-3799	59	3	-	-	PUNCT
gs-3799	59	4	loop	loop	NOUN
gs-3799	59	5	mechanism	mechanism	NOUN
gs-3799	59	6	is	be	AUX
gs-3799	59	7	commonly	commonly	ADV
gs-3799	59	8	employed	employ	VERB
gs-3799	59	9	with	with	ADP
gs-3799	59	10	cpb	cpb	NOUN
gs-3799	59	11	systems	system	NOUN
gs-3799	59	12	,	,	PUNCT
gs-3799	59	13	requiring	require	VERB
gs-3799	59	14	clinicians	clinician	NOUN
gs-3799	59	15	to	to	PART
gs-3799	59	16	manually	manually	ADV
gs-3799	59	17	modulate	modulate	VERB
gs-3799	59	18	parameters	parameter	NOUN
gs-3799	59	19	when	when	SCONJ
gs-3799	59	20	readings	reading	NOUN
gs-3799	59	21	are	be	AUX
gs-3799	59	22	infrequent	infrequent	ADJ
gs-3799	59	23	.	.	PUNCT
gs-3799	60	1	therefore	therefore	ADV
gs-3799	60	2	,	,	PUNCT
gs-3799	60	3	the	the	DET
gs-3799	60	4	effectiveness	effectiveness	NOUN
gs-3799	60	5	of	of	ADP
gs-3799	60	6	this	this	DET
gs-3799	60	7	method	method	NOUN
gs-3799	60	8	has	have	AUX
gs-3799	60	9	outweighed	outweigh	VERB
gs-3799	60	10	the	the	DET
gs-3799	60	11	efficiency	efficiency	NOUN
gs-3799	60	12	regarding	regard	VERB
gs-3799	60	13	pediatric	pediatric	ADJ
gs-3799	60	14	cardiac	cardiac	ADJ
gs-3799	60	15	surgery	surgery	NOUN
gs-3799	60	16	,	,	PUNCT
gs-3799	60	17	where	where	SCONJ
gs-3799	60	18	rapid	rapid	ADJ
gs-3799	60	19	&	&	CCONJ
gs-3799	60	20	unpredictable	unpredictable	ADJ
gs-3799	60	21	physiological	physiological	ADJ
gs-3799	60	22	changes	change	NOUN
gs-3799	60	23	may	may	AUX
gs-3799	60	24	occur	occur	VERB
gs-3799	60	25	.	.	PUNCT
gs-3799	61	1	on	on	ADP
gs-3799	61	2	the	the	DET
gs-3799	61	3	contrary	contrary	ADJ
gs-3799	61	4	,	,	PUNCT
gs-3799	61	5	closed	closed	ADJ
gs-3799	61	6	-	-	PUNCT
gs-3799	61	7	loop	loop	NOUN
gs-3799	61	8	cpb	cpb	NOUN
gs-3799	61	9	systems	system	NOUN
gs-3799	61	10	incorporate	incorporate	VERB
gs-3799	61	11	real	real	ADJ
gs-3799	61	12	-	-	PUNCT
gs-3799	61	13	time	time	NOUN
gs-3799	61	14	monitoring	monitoring	NOUN
gs-3799	61	15	and	and	CCONJ
gs-3799	61	16	efficiently	efficiently	ADV
gs-3799	61	17	automate	automate	ADJ
gs-3799	61	18	control	control	NOUN
gs-3799	61	19	algorithms	algorithm	NOUN
gs-3799	61	20	to	to	PART
gs-3799	61	21	maintain	maintain	VERB
gs-3799	61	22	perfusion	perfusion	NOUN
gs-3799	61	23	variables	variable	NOUN
gs-3799	61	24	within	within	ADP
gs-3799	61	25	desired	desire	VERB
gs-3799	61	26	intervals	interval	NOUN
gs-3799	61	27	.	.	PUNCT
gs-3799	62	1	the	the	DET
gs-3799	62	2	conceptualization	conceptualization	NOUN
gs-3799	62	3	of	of	ADP
gs-3799	62	4	this	this	DET
gs-3799	62	5	hypothesis	hypothesis	NOUN
gs-3799	62	6	stems	stem	VERB
gs-3799	62	7	from	from	ADP
gs-3799	62	8	the	the	DET
gs-3799	62	9	successful	successful	ADJ
gs-3799	62	10	application	application	NOUN
gs-3799	62	11	of	of	ADP
gs-3799	62	12	ventilator	ventilator	NOUN
gs-3799	62	13	systems	systems	PROPN
gs-3799	62	14	&	&	CCONJ
gs-3799	62	15	hybrid	hybrid	ADJ
gs-3799	62	16	closed	closed	ADJ
gs-3799	62	17	-	-	PUNCT
gs-3799	62	18	loop	loop	NOUN
gs-3799	62	19	systems	system	NOUN
gs-3799	62	20	in	in	ADP
gs-3799	62	21	managing	manage	VERB
gs-3799	62	22	type	type	NOUN
gs-3799	62	23	1	1	NUM
gs-3799	62	24	diabetes	diabetes	NOUN
gs-3799	62	25	in	in	ADP
gs-3799	62	26	young	young	ADJ
gs-3799	62	27	children	child	NOUN
gs-3799	62	28	.	.	PUNCT
gs-3799	63	1	in	in	ADP
gs-3799	63	2	pediatric	pediatric	ADJ
gs-3799	63	3	cpb	cpb	NOUN
gs-3799	63	4	,	,	PUNCT
gs-3799	63	5	closed	closed	ADJ
gs-3799	63	6	-	-	PUNCT
gs-3799	63	7	loop	loop	NOUN
gs-3799	63	8	systems	system	NOUN
gs-3799	63	9	monitor	monitor	VERB
gs-3799	63	10	parameters	parameter	NOUN
gs-3799	63	11	such	such	ADJ
gs-3799	63	12	as	as	ADP
gs-3799	63	13	mean	mean	ADJ
gs-3799	63	14	arterial	arterial	ADJ
gs-3799	63	15	pressure	pressure	NOUN
gs-3799	63	16	(	(	PUNCT
gs-3799	63	17	map	map	NOUN
gs-3799	63	18	)	)	PUNCT
gs-3799	63	19	,	,	PUNCT
gs-3799	63	20	cerebral	cerebral	ADJ
gs-3799	63	21	oxygenation	oxygenation	NOUN
gs-3799	63	22	,	,	PUNCT
gs-3799	63	23	mixed	mixed	ADJ
gs-3799	63	24	venous	venous	ADJ
gs-3799	63	25	oxygen	oxygen	NOUN
gs-3799	63	26	saturation	saturation	NOUN
gs-3799	63	27	(	(	PUNCT
gs-3799	63	28	svo2	svo2	PROPN
gs-3799	63	29	)	)	PUNCT
gs-3799	63	30	,	,	PUNCT
gs-3799	63	31	and	and	CCONJ
gs-3799	63	32	temperature	temperature	NOUN
gs-3799	63	33	.	.	PUNCT
gs-3799	64	1	these	these	DET
gs-3799	64	2	readings	reading	NOUN
gs-3799	64	3	feed	feed	VERB
gs-3799	64	4	into	into	ADP
gs-3799	64	5	a	a	DET
gs-3799	64	6	computerized	computerized	ADJ
gs-3799	64	7	controller	controller	NOUN
gs-3799	64	8	,	,	PUNCT
gs-3799	64	9	which	which	PRON
gs-3799	64	10	adjusts	adjust	VERB
gs-3799	64	11	flow	flow	NOUN
gs-3799	64	12	rates	rate	NOUN
gs-3799	64	13	,	,	PUNCT
gs-3799	64	14	pump	pump	NOUN
gs-3799	64	15	speed	speed	NOUN
gs-3799	64	16	,	,	PUNCT
gs-3799	64	17	oxygen	oxygen	NOUN
gs-3799	64	18	delivery	delivery	NOUN
gs-3799	64	19	,	,	PUNCT
gs-3799	64	20	or	or	CCONJ
gs-3799	64	21	cooling	cool	VERB
gs-3799	64	22	mechanisms	mechanism	NOUN
gs-3799	64	23	accordingly	accordingly	ADV
gs-3799	64	24	.	.	PUNCT
gs-3799	65	1	the	the	DET
gs-3799	65	2	field	field	NOUN
gs-3799	65	3	of	of	ADP
gs-3799	65	4	cardiothoracic	cardiothoracic	NOUN
gs-3799	65	5	surgery	surgery	NOUN
gs-3799	65	6	has	have	AUX
gs-3799	65	7	undergone	undergo	VERB
gs-3799	65	8	significant	significant	ADJ
gs-3799	65	9	evolution	evolution	NOUN
gs-3799	65	10	since	since	SCONJ
gs-3799	65	11	the	the	DET
gs-3799	65	12	advent	advent	NOUN
gs-3799	65	13	of	of	ADP
gs-3799	65	14	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	65	15	bypass	bypass	NOUN
gs-3799	65	16	(	(	PUNCT
gs-3799	65	17	cpb	cpb	NOUN
gs-3799	65	18	)	)	PUNCT
gs-3799	65	19	systems	system	NOUN
gs-3799	65	20	in	in	ADP
gs-3799	65	21	the	the	DET
gs-3799	65	22	mid-20th	mid-20th	NUM
gs-3799	65	23	century	century	NOUN
gs-3799	65	24	.	.	PUNCT
gs-3799	66	1	these	these	DET
gs-3799	66	2	systems	system	NOUN
gs-3799	66	3	have	have	AUX
gs-3799	66	4	become	become	VERB
gs-3799	66	5	the	the	DET
gs-3799	66	6	cornerstone	cornerstone	NOUN
gs-3799	66	7	of	of	ADP
gs-3799	66	8	open	open	ADJ
gs-3799	66	9	-	-	PUNCT
gs-3799	66	10	heart	heart	NOUN
gs-3799	66	11	procedures	procedure	NOUN
gs-3799	66	12	,	,	PUNCT
gs-3799	66	13	enabling	enable	VERB
gs-3799	66	14	temporary	temporary	ADJ
gs-3799	66	15	support	support	NOUN
gs-3799	66	16	of	of	ADP
gs-3799	66	17	systemic	systemic	ADJ
gs-3799	66	18	circulation	circulation	NOUN
gs-3799	66	19	and	and	CCONJ
gs-3799	66	20	oxygenation	oxygenation	NOUN
gs-3799	66	21	during	during	ADP
gs-3799	66	22	operations	operation	NOUN
gs-3799	66	23	requiring	require	VERB
gs-3799	66	24	the	the	DET
gs-3799	66	25	heart	heart	NOUN
gs-3799	66	26	and	and	CCONJ
gs-3799	66	27	lungs	lung	NOUN
gs-3799	66	28	to	to	PART
gs-3799	66	29	be	be	AUX
gs-3799	66	30	functionally	functionally	ADV
gs-3799	66	31	isolated	isolate	VERB
gs-3799	66	32	.	.	PUNCT
gs-3799	67	1	while	while	SCONJ
gs-3799	67	2	traditional	traditional	ADJ
gs-3799	67	3	cpb	cpb	PROPN
gs-3799	67	4	machines	machine	NOUN
gs-3799	67	5	have	have	AUX
gs-3799	67	6	proven	prove	VERB
gs-3799	67	7	effective	effective	ADJ
gs-3799	67	8	in	in	ADP
gs-3799	67	9	their	their	PRON
gs-3799	67	10	essential	essential	ADJ
gs-3799	67	11	purpose	purpose	NOUN
gs-3799	67	12	,	,	PUNCT
gs-3799	67	13	their	their	PRON
gs-3799	67	14	design	design	NOUN
gs-3799	67	15	is	be	AUX
gs-3799	67	16	primarily	primarily	ADV
gs-3799	67	17	open	open	ADJ
gs-3799	67	18	-	-	PUNCT
gs-3799	67	19	loop	loop	NOUN
gs-3799	67	20	and	and	CCONJ
gs-3799	67	21	dependent	dependent	ADJ
gs-3799	67	22	on	on	ADP
gs-3799	67	23	manual	manual	ADJ
gs-3799	67	24	inputs	input	NOUN
gs-3799	67	25	by	by	ADP
gs-3799	67	26	perfusionists	perfusionist	NOUN
gs-3799	67	27	and	and	CCONJ
gs-3799	67	28	clinicians	clinician	NOUN
gs-3799	67	29	.	.	PUNCT
gs-3799	68	1	this	this	DET
gs-3799	68	2	architecture	architecture	NOUN
gs-3799	68	3	introduces	introduce	VERB
gs-3799	68	4	inherent	inherent	ADJ
gs-3799	68	5	limitations	limitation	NOUN
gs-3799	68	6	,	,	PUNCT
gs-3799	68	7	such	such	ADJ
gs-3799	68	8	as	as	ADP
gs-3799	68	9	lag	lag	NOUN
gs-3799	68	10	in	in	ADP
gs-3799	68	11	physiological	physiological	ADJ
gs-3799	68	12	response	response	NOUN
gs-3799	68	13	adjustments	adjustment	NOUN
gs-3799	68	14	,	,	PUNCT
gs-3799	68	15	inconsistent	inconsistent	ADJ
gs-3799	68	16	pharmacologic	pharmacologic	ADJ
gs-3799	68	17	management	management	NOUN
gs-3799	68	18	,	,	PUNCT
gs-3799	68	19	and	and	CCONJ
gs-3799	68	20	susceptibility	susceptibility	NOUN
gs-3799	68	21	to	to	ADP
gs-3799	68	22	human	human	ADJ
gs-3799	68	23	error	error	NOUN
gs-3799	68	24	.	.	PUNCT
gs-3799	69	1	as	as	SCONJ
gs-3799	69	2	surgical	surgical	ADJ
gs-3799	69	3	complexity	complexity	NOUN
gs-3799	69	4	increases	increase	NOUN
gs-3799	69	5	and	and	CCONJ
gs-3799	69	6	patient	patient	ADJ
gs-3799	69	7	populations	population	NOUN
gs-3799	69	8	diversify	diversify	VERB
gs-3799	69	9	in	in	ADP
gs-3799	69	10	age	age	NOUN
gs-3799	69	11	,	,	PUNCT
gs-3799	69	12	comorbidities	comorbiditie	NOUN
gs-3799	69	13	,	,	PUNCT
gs-3799	69	14	and	and	CCONJ
gs-3799	69	15	risk	risk	NOUN
gs-3799	69	16	profiles	profile	NOUN
gs-3799	69	17	,	,	PUNCT
gs-3799	69	18	the	the	DET
gs-3799	69	19	demand	demand	NOUN
gs-3799	69	20	for	for	ADP
gs-3799	69	21	more	more	ADV
gs-3799	69	22	advanced	advanced	ADJ
gs-3799	69	23	,	,	PUNCT
gs-3799	69	24	intelligent	intelligent	ADJ
gs-3799	69	25	,	,	PUNCT
gs-3799	69	26	and	and	CCONJ
gs-3799	69	27	responsive	responsive	ADJ
gs-3799	69	28	bypass	bypass	NOUN
gs-3799	69	29	systems	system	NOUN
gs-3799	69	30	has	have	AUX
gs-3799	69	31	grown	grow	VERB
gs-3799	69	32	exponentially	exponentially	ADV
gs-3799	69	33	.	.	PUNCT
gs-3799	70	1	closed	close	VERB
gs-3799	70	2	-	-	PUNCT
gs-3799	70	3	loop	loop	NOUN
gs-3799	70	4	cpb	cpb	PROPN
gs-3799	70	5	systems	system	NOUN
gs-3799	70	6	represent	represent	VERB
gs-3799	70	7	a	a	DET
gs-3799	70	8	paradigm	paradigm	NOUN
gs-3799	70	9	shift	shift	NOUN
gs-3799	70	10	in	in	ADP
gs-3799	70	11	extracorporeal	extracorporeal	NOUN
gs-3799	70	12	circulation	circulation	NOUN
gs-3799	70	13	technology	technology	NOUN
gs-3799	70	14	.	.	PUNCT
gs-3799	71	1	these	these	DET
gs-3799	71	2	systems	system	NOUN
gs-3799	71	3	utilize	utilize	VERB
gs-3799	71	4	continuous	continuous	ADJ
gs-3799	71	5	feedback	feedback	NOUN
gs-3799	71	6	mechanisms	mechanism	NOUN
gs-3799	71	7	and	and	CCONJ
gs-3799	71	8	algorithmic	algorithmic	ADJ
gs-3799	71	9	controls	control	NOUN
gs-3799	71	10	to	to	PART
gs-3799	71	11	automatically	automatically	ADV
gs-3799	71	12	adjust	adjust	VERB
gs-3799	71	13	physiological	physiological	ADJ
gs-3799	71	14	parameters	parameter	NOUN
gs-3799	71	15	in	in	ADP
gs-3799	71	16	real	real	ADJ
gs-3799	71	17	time	time	NOUN
gs-3799	71	18	.	.	PUNCT
gs-3799	72	1	by	by	ADP
gs-3799	72	2	integrating	integrate	VERB
gs-3799	72	3	advanced	advanced	ADJ
gs-3799	72	4	monitoring	monitoring	NOUN
gs-3799	72	5	modalities	modality	NOUN
gs-3799	72	6	,	,	PUNCT
gs-3799	72	7	smart	smart	ADJ
gs-3799	72	8	sensors	sensor	NOUN
gs-3799	72	9	,	,	PUNCT
gs-3799	72	10	and	and	CCONJ
gs-3799	72	11	precision	precision	VERB
gs-3799	72	12	pharmacologic	pharmacologic	ADJ
gs-3799	72	13	delivery	delivery	NOUN
gs-3799	72	14	,	,	PUNCT
gs-3799	72	15	closed	closed	ADJ
gs-3799	72	16	-	-	PUNCT
gs-3799	72	17	loop	loop	NOUN
gs-3799	72	18	platforms	platform	NOUN
gs-3799	72	19	aim	aim	VERB
gs-3799	72	20	to	to	PART
gs-3799	72	21	minimize	minimize	VERB
gs-3799	72	22	the	the	DET
gs-3799	72	23	variability	variability	NOUN
gs-3799	72	24	and	and	CCONJ
gs-3799	72	25	latency	latency	NOUN
gs-3799	72	26	associated	associate	VERB
gs-3799	72	27	with	with	ADP
gs-3799	72	28	traditional	traditional	ADJ
gs-3799	72	29	cpb	cpb	NOUN
gs-3799	72	30	.	.	PUNCT
gs-3799	73	1	the	the	DET
gs-3799	73	2	ultimate	ultimate	ADJ
gs-3799	73	3	goal	goal	NOUN
gs-3799	73	4	is	be	AUX
gs-3799	73	5	to	to	PART
gs-3799	73	6	optimize	optimize	VERB
gs-3799	73	7	patient	patient	ADJ
gs-3799	73	8	outcomes	outcome	NOUN
gs-3799	73	9	,	,	PUNCT
gs-3799	73	10	reduce	reduce	VERB
gs-3799	73	11	perioperative	perioperative	ADJ
gs-3799	73	12	complications	complication	NOUN
gs-3799	73	13	,	,	PUNCT
gs-3799	73	14	and	and	CCONJ
gs-3799	73	15	enhance	enhance	VERB
gs-3799	73	16	the	the	DET
gs-3799	73	17	overall	overall	ADJ
gs-3799	73	18	safety	safety	NOUN
gs-3799	73	19	and	and	CCONJ
gs-3799	73	20	efficacy	efficacy	NOUN
gs-3799	73	21	of	of	ADP
gs-3799	73	22	cardiac	cardiac	ADJ
gs-3799	73	23	surgical	surgical	ADJ
gs-3799	73	24	interventions	intervention	NOUN
gs-3799	73	25	.	.	PUNCT
gs-3799	74	1	this	this	DET
gs-3799	74	2	transformation	transformation	NOUN
gs-3799	74	3	is	be	AUX
gs-3799	74	4	not	not	PART
gs-3799	74	5	merely	merely	ADV
gs-3799	74	6	incremental	incremental	ADJ
gs-3799	74	7	but	but	CCONJ
gs-3799	74	8	foundational	foundational	ADJ
gs-3799	74	9	,	,	PUNCT
gs-3799	74	10	necessitating	necessitate	VERB
gs-3799	74	11	a	a	DET
gs-3799	74	12	reevaluation	reevaluation	NOUN
gs-3799	74	13	of	of	ADP
gs-3799	74	14	the	the	DET
gs-3799	74	15	theoretical	theoretical	ADJ
gs-3799	74	16	,	,	PUNCT
gs-3799	74	17	clinical	clinical	ADJ
gs-3799	74	18	,	,	PUNCT
gs-3799	74	19	and	and	CCONJ
gs-3799	74	20	technological	technological	ADJ
gs-3799	74	21	frameworks	framework	NOUN
gs-3799	74	22	underpinning	underpin	VERB
gs-3799	74	23	extracorporeal	extracorporeal	NOUN
gs-3799	74	24	circulation	circulation	NOUN
gs-3799	74	25	.	.	PUNCT
gs-3799	75	1	real	real	ADJ
gs-3799	75	2	-	-	PUNCT
gs-3799	75	3	time	time	NOUN
gs-3799	75	4	monitoring	monitoring	NOUN
gs-3799	75	5	plays	play	VERB
gs-3799	75	6	a	a	DET
gs-3799	75	7	critical	critical	ADJ
gs-3799	75	8	role	role	NOUN
gs-3799	75	9	in	in	ADP
gs-3799	75	10	enabling	enable	VERB
gs-3799	75	11	closed	close	VERB
gs-3799	75	12	-	-	PUNCT
gs-3799	75	13	loop	loop	NOUN
gs-3799	75	14	control	control	NOUN
gs-3799	75	15	.	.	PUNCT
gs-3799	76	1	unlike	unlike	ADP
gs-3799	76	2	conventional	conventional	ADJ
gs-3799	76	3	systems	system	NOUN
gs-3799	76	4	that	that	PRON
gs-3799	76	5	rely	rely	VERB
gs-3799	76	6	on	on	ADP
gs-3799	76	7	intermittent	intermittent	ADJ
gs-3799	76	8	laboratory	laboratory	NOUN
gs-3799	76	9	tests	test	NOUN
gs-3799	76	10	and	and	CCONJ
gs-3799	76	11	clinical	clinical	ADJ
gs-3799	76	12	observations	observation	NOUN
gs-3799	76	13	,	,	PUNCT
gs-3799	76	14	next	next	ADJ
gs-3799	76	15	-	-	PUNCT
gs-3799	76	16	generation	generation	NOUN
gs-3799	76	17	cpb	cpb	NOUN
gs-3799	76	18	systems	system	NOUN
gs-3799	76	19	georgian	georgian	NOUN
gs-3799	76	20	scientists/	scientists/	NUM
gs-3799	76	21	.	.	PUNCT
gs-3799	77	1	7	7	NUM
gs-3799	77	2	n	n	DET
gs-3799	77	3	2	2	NUM
gs-3799	77	4	,	,	PUNCT
gs-3799	77	5	2025	2025	NUM
gs-3799	77	6	385	385	NUM
gs-3799	77	7	incorporate	incorporate	VERB
gs-3799	77	8	continuous	continuous	ADJ
gs-3799	77	9	data	datum	NOUN
gs-3799	77	10	streams	stream	NOUN
gs-3799	77	11	from	from	ADP
gs-3799	77	12	a	a	DET
gs-3799	77	13	range	range	NOUN
gs-3799	77	14	of	of	ADP
gs-3799	77	15	monitoring	monitor	VERB
gs-3799	77	16	devices	device	NOUN
gs-3799	77	17	.	.	PUNCT
gs-3799	78	1	these	these	PRON
gs-3799	78	2	include	include	VERB
gs-3799	78	3	sensors	sensor	NOUN
gs-3799	78	4	for	for	ADP
gs-3799	78	5	blood	blood	NOUN
gs-3799	78	6	gases	gas	NOUN
gs-3799	78	7	,	,	PUNCT
gs-3799	78	8	oxygen	oxygen	NOUN
gs-3799	78	9	saturation	saturation	NOUN
gs-3799	78	10	,	,	PUNCT
gs-3799	78	11	hemoglobin	hemoglobin	NOUN
gs-3799	78	12	concentration	concentration	NOUN
gs-3799	78	13	,	,	PUNCT
gs-3799	78	14	lactate	lactate	NOUN
gs-3799	78	15	levels	level	NOUN
gs-3799	78	16	,	,	PUNCT
gs-3799	78	17	systemic	systemic	ADJ
gs-3799	78	18	vascular	vascular	ADJ
gs-3799	78	19	resistance	resistance	NOUN
gs-3799	78	20	,	,	PUNCT
gs-3799	78	21	and	and	CCONJ
gs-3799	78	22	cerebral	cerebral	ADJ
gs-3799	78	23	perfusion	perfusion	NOUN
gs-3799	78	24	,	,	PUNCT
gs-3799	78	25	among	among	ADP
gs-3799	78	26	others	other	NOUN
gs-3799	78	27	.	.	PUNCT
gs-3799	79	1	data	datum	NOUN
gs-3799	79	2	from	from	ADP
gs-3799	79	3	these	these	DET
gs-3799	79	4	sensors	sensor	NOUN
gs-3799	79	5	are	be	AUX
gs-3799	79	6	processed	process	VERB
gs-3799	79	7	in	in	ADP
gs-3799	79	8	real	real	ADJ
gs-3799	79	9	time	time	NOUN
gs-3799	79	10	to	to	PART
gs-3799	79	11	inform	inform	VERB
gs-3799	79	12	decision	decision	NOUN
gs-3799	79	13	-	-	PUNCT
gs-3799	79	14	making	make	VERB
gs-3799	79	15	algorithms	algorithm	NOUN
gs-3799	79	16	that	that	PRON
gs-3799	79	17	modulate	modulate	VERB
gs-3799	79	18	perfusion	perfusion	NOUN
gs-3799	79	19	parameters	parameter	NOUN
gs-3799	79	20	such	such	ADJ
gs-3799	79	21	as	as	ADP
gs-3799	79	22	pump	pump	NOUN
gs-3799	79	23	speed	speed	NOUN
gs-3799	79	24	,	,	PUNCT
gs-3799	79	25	flow	flow	NOUN
gs-3799	79	26	rate	rate	NOUN
gs-3799	79	27	,	,	PUNCT
gs-3799	79	28	and	and	CCONJ
gs-3799	79	29	temperature	temperature	NOUN
gs-3799	79	30	.	.	PUNCT
gs-3799	80	1	this	this	DET
gs-3799	80	2	level	level	NOUN
gs-3799	80	3	of	of	ADP
gs-3799	80	4	control	control	NOUN
gs-3799	80	5	ensures	ensure	VERB
gs-3799	80	6	that	that	SCONJ
gs-3799	80	7	patient	patient	ADJ
gs-3799	80	8	physiology	physiology	NOUN
gs-3799	80	9	is	be	AUX
gs-3799	80	10	maintained	maintain	VERB
gs-3799	80	11	within	within	ADP
gs-3799	80	12	tightly	tightly	ADV
gs-3799	80	13	regulated	regulate	VERB
gs-3799	80	14	limits	limit	NOUN
gs-3799	80	15	,	,	PUNCT
gs-3799	80	16	reducing	reduce	VERB
gs-3799	80	17	intraoperative	intraoperative	ADJ
gs-3799	80	18	stress	stress	NOUN
gs-3799	80	19	and	and	CCONJ
gs-3799	80	20	improving	improve	VERB
gs-3799	80	21	the	the	DET
gs-3799	80	22	predictability	predictability	NOUN
gs-3799	80	23	of	of	ADP
gs-3799	80	24	surgical	surgical	ADJ
gs-3799	80	25	outcomes	outcome	NOUN
gs-3799	80	26	.	.	PUNCT
gs-3799	81	1	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	81	2	integration	integration	NOUN
gs-3799	81	3	is	be	AUX
gs-3799	81	4	another	another	DET
gs-3799	81	5	key	key	ADJ
gs-3799	81	6	dimension	dimension	NOUN
gs-3799	81	7	of	of	ADP
gs-3799	81	8	innovation	innovation	NOUN
gs-3799	81	9	in	in	ADP
gs-3799	81	10	closed	closed	ADJ
gs-3799	81	11	-	-	PUNCT
gs-3799	81	12	loop	loop	NOUN
gs-3799	81	13	cpb	cpb	PROPN
gs-3799	81	14	systems	system	NOUN
gs-3799	81	15	.	.	PUNCT
gs-3799	82	1	the	the	DET
gs-3799	82	2	administration	administration	NOUN
gs-3799	82	3	of	of	ADP
gs-3799	82	4	vasoactive	vasoactive	ADJ
gs-3799	82	5	drugs	drug	NOUN
gs-3799	82	6	,	,	PUNCT
gs-3799	82	7	anesthetics	anesthetic	NOUN
gs-3799	82	8	,	,	PUNCT
gs-3799	82	9	anticoagulants	anticoagulant	NOUN
gs-3799	82	10	,	,	PUNCT
gs-3799	82	11	and	and	CCONJ
gs-3799	82	12	anti	anti	ADJ
gs-3799	82	13	-	-	ADJ
gs-3799	82	14	inflammatory	inflammatory	ADJ
gs-3799	82	15	agents	agent	NOUN
gs-3799	82	16	is	be	AUX
gs-3799	82	17	critical	critical	ADJ
gs-3799	82	18	to	to	ADP
gs-3799	82	19	the	the	DET
gs-3799	82	20	stability	stability	NOUN
gs-3799	82	21	of	of	ADP
gs-3799	82	22	patients	patient	NOUN
gs-3799	82	23	on	on	ADP
gs-3799	82	24	bypass	bypass	NOUN
gs-3799	82	25	.	.	PUNCT
gs-3799	83	1	traditionally	traditionally	ADV
gs-3799	83	2	,	,	PUNCT
gs-3799	83	3	these	these	DET
gs-3799	83	4	medications	medication	NOUN
gs-3799	83	5	are	be	AUX
gs-3799	83	6	administered	administer	VERB
gs-3799	83	7	manually	manually	ADV
gs-3799	83	8	,	,	PUNCT
gs-3799	83	9	based	base	VERB
gs-3799	83	10	on	on	ADP
gs-3799	83	11	intermittent	intermittent	ADJ
gs-3799	83	12	clinical	clinical	ADJ
gs-3799	83	13	assessments	assessment	NOUN
gs-3799	83	14	.	.	PUNCT
gs-3799	84	1	in	in	ADP
gs-3799	84	2	closed	closed	ADJ
gs-3799	84	3	-	-	PUNCT
gs-3799	84	4	loop	loop	NOUN
gs-3799	84	5	systems	system	NOUN
gs-3799	84	6	,	,	PUNCT
gs-3799	84	7	drug	drug	NOUN
gs-3799	84	8	delivery	delivery	NOUN
gs-3799	84	9	is	be	AUX
gs-3799	84	10	automated	automate	VERB
gs-3799	84	11	and	and	CCONJ
gs-3799	84	12	titrated	titrate	VERB
gs-3799	84	13	in	in	ADP
gs-3799	84	14	response	response	NOUN
gs-3799	84	15	to	to	ADP
gs-3799	84	16	real	real	ADJ
gs-3799	84	17	-	-	PUNCT
gs-3799	84	18	time	time	NOUN
gs-3799	84	19	physiological	physiological	ADJ
gs-3799	84	20	inputs	input	NOUN
gs-3799	84	21	.	.	PUNCT
gs-3799	85	1	for	for	ADP
gs-3799	85	2	example	example	NOUN
gs-3799	85	3	,	,	PUNCT
gs-3799	85	4	vasopressors	vasopressor	NOUN
gs-3799	85	5	can	can	AUX
gs-3799	85	6	be	be	AUX
gs-3799	85	7	adjusted	adjust	VERB
gs-3799	85	8	automatically	automatically	ADV
gs-3799	85	9	to	to	PART
gs-3799	85	10	maintain	maintain	VERB
gs-3799	85	11	target	target	NOUN
gs-3799	85	12	mean	mean	NOUN
gs-3799	85	13	arterial	arterial	ADJ
gs-3799	85	14	pressure	pressure	NOUN
gs-3799	85	15	,	,	PUNCT
gs-3799	85	16	while	while	SCONJ
gs-3799	85	17	heparin	heparin	NOUN
gs-3799	85	18	can	can	AUX
gs-3799	85	19	be	be	AUX
gs-3799	85	20	precisely	precisely	ADV
gs-3799	85	21	dosed	dose	VERB
gs-3799	85	22	based	base	VERB
gs-3799	85	23	on	on	ADP
gs-3799	85	24	activated	activate	VERB
gs-3799	85	25	clotting	clotting	NOUN
gs-3799	85	26	time	time	NOUN
gs-3799	85	27	or	or	CCONJ
gs-3799	85	28	heparin	heparin	ADJ
gs-3799	85	29	concentration	concentration	NOUN
gs-3799	85	30	measured	measure	VERB
gs-3799	85	31	continuously	continuously	ADV
gs-3799	85	32	.	.	PUNCT
gs-3799	86	1	this	this	DET
gs-3799	86	2	automated	automate	VERB
gs-3799	86	3	pharmacologic	pharmacologic	ADJ
gs-3799	86	4	regulation	regulation	NOUN
gs-3799	86	5	reduces	reduce	VERB
gs-3799	86	6	the	the	DET
gs-3799	86	7	risk	risk	NOUN
gs-3799	86	8	of	of	ADP
gs-3799	86	9	underor	underor	NOUN
gs-3799	86	10	over	over	ADP
gs-3799	86	11	-	-	PUNCT
gs-3799	86	12	dosing	dosing	NOUN
gs-3799	86	13	,	,	PUNCT
gs-3799	86	14	thereby	thereby	ADV
gs-3799	86	15	minimizing	minimize	VERB
gs-3799	86	16	adverse	adverse	ADJ
gs-3799	86	17	effects	effect	NOUN
gs-3799	86	18	and	and	CCONJ
gs-3799	86	19	improving	improve	VERB
gs-3799	86	20	the	the	DET
gs-3799	86	21	precision	precision	NOUN
gs-3799	86	22	of	of	ADP
gs-3799	86	23	perioperative	perioperative	ADJ
gs-3799	86	24	care	care	NOUN
gs-3799	86	25	.	.	PUNCT
gs-3799	87	1	the	the	DET
gs-3799	87	2	integration	integration	NOUN
gs-3799	87	3	of	of	ADP
gs-3799	87	4	digital	digital	ADJ
gs-3799	87	5	technologies	technology	NOUN
gs-3799	87	6	,	,	PUNCT
gs-3799	87	7	including	include	VERB
gs-3799	87	8	artificial	artificial	ADJ
gs-3799	87	9	intelligence	intelligence	NOUN
gs-3799	87	10	(	(	PUNCT
gs-3799	87	11	ai	ai	NOUN
gs-3799	87	12	)	)	PUNCT
gs-3799	87	13	,	,	PUNCT
gs-3799	87	14	machine	machine	NOUN
gs-3799	87	15	learning	learning	NOUN
gs-3799	87	16	(	(	PUNCT
gs-3799	87	17	ml	ml	NOUN
gs-3799	87	18	)	)	PUNCT
gs-3799	87	19	,	,	PUNCT
gs-3799	87	20	and	and	CCONJ
gs-3799	87	21	internet	internet	NOUN
gs-3799	87	22	of	of	ADP
gs-3799	87	23	things	thing	NOUN
gs-3799	87	24	(	(	PUNCT
gs-3799	87	25	iot	iot	NOUN
gs-3799	87	26	)	)	PUNCT
gs-3799	87	27	frameworks	framework	NOUN
gs-3799	87	28	,	,	PUNCT
gs-3799	87	29	further	far	ADV
gs-3799	87	30	enhances	enhance	VERB
gs-3799	87	31	the	the	DET
gs-3799	87	32	potential	potential	NOUN
gs-3799	87	33	of	of	ADP
gs-3799	87	34	closed	closed	ADJ
gs-3799	87	35	-	-	PUNCT
gs-3799	87	36	loop	loop	NOUN
gs-3799	87	37	systems	system	NOUN
gs-3799	87	38	.	.	PUNCT
gs-3799	88	1	these	these	DET
gs-3799	88	2	technologies	technology	NOUN
gs-3799	88	3	enable	enable	VERB
gs-3799	88	4	predictive	predictive	ADJ
gs-3799	88	5	analytics	analytic	NOUN
gs-3799	88	6	,	,	PUNCT
gs-3799	88	7	adaptive	adaptive	ADJ
gs-3799	88	8	learning	learning	NOUN
gs-3799	88	9	algorithms	algorithm	NOUN
gs-3799	88	10	,	,	PUNCT
gs-3799	88	11	and	and	CCONJ
gs-3799	88	12	cloud	cloud	NOUN
gs-3799	88	13	-	-	PUNCT
gs-3799	88	14	based	base	VERB
gs-3799	88	15	data	datum	NOUN
gs-3799	88	16	storage	storage	NOUN
gs-3799	88	17	,	,	PUNCT
gs-3799	88	18	facilitating	facilitate	VERB
gs-3799	88	19	individualized	individualized	ADJ
gs-3799	88	20	patient	patient	NOUN
gs-3799	88	21	management	management	NOUN
gs-3799	88	22	and	and	CCONJ
gs-3799	88	23	longitudinal	longitudinal	ADJ
gs-3799	88	24	outcome	outcome	NOUN
gs-3799	88	25	analysis	analysis	NOUN
gs-3799	88	26	.	.	PUNCT
gs-3799	89	1	as	as	ADP
gs-3799	89	2	the	the	DET
gs-3799	89	3	healthcare	healthcare	NOUN
gs-3799	89	4	industry	industry	NOUN
gs-3799	89	5	shifts	shift	NOUN
gs-3799	89	6	toward	toward	ADP
gs-3799	89	7	data	data	NOUN
gs-3799	89	8	-	-	PUNCT
gs-3799	89	9	driven	drive	VERB
gs-3799	89	10	and	and	CCONJ
gs-3799	89	11	precision	precision	NOUN
gs-3799	89	12	medicine	medicine	NOUN
gs-3799	89	13	,	,	PUNCT
gs-3799	89	14	the	the	DET
gs-3799	89	15	incorporation	incorporation	NOUN
gs-3799	89	16	of	of	ADP
gs-3799	89	17	these	these	DET
gs-3799	89	18	digital	digital	ADJ
gs-3799	89	19	tools	tool	NOUN
gs-3799	89	20	in	in	ADP
gs-3799	89	21	cpb	cpb	PROPN
gs-3799	89	22	systems	system	NOUN
gs-3799	89	23	aligns	align	VERB
gs-3799	89	24	with	with	ADP
gs-3799	89	25	broader	broad	ADJ
gs-3799	89	26	trends	trend	NOUN
gs-3799	89	27	in	in	ADP
gs-3799	89	28	biomedical	biomedical	ADJ
gs-3799	89	29	innovation	innovation	NOUN
gs-3799	89	30	.	.	PUNCT
gs-3799	90	1	however	however	ADV
gs-3799	90	2	,	,	PUNCT
gs-3799	90	3	the	the	DET
gs-3799	90	4	complexity	complexity	NOUN
gs-3799	90	5	of	of	ADP
gs-3799	90	6	these	these	DET
gs-3799	90	7	systems	system	NOUN
gs-3799	90	8	also	also	ADV
gs-3799	90	9	introduces	introduce	VERB
gs-3799	90	10	new	new	ADJ
gs-3799	90	11	challenges	challenge	NOUN
gs-3799	90	12	in	in	ADP
gs-3799	90	13	terms	term	NOUN
gs-3799	90	14	of	of	ADP
gs-3799	90	15	cybersecurity	cybersecurity	NOUN
gs-3799	90	16	,	,	PUNCT
gs-3799	90	17	data	data	NOUN
gs-3799	90	18	privacy	privacy	NOUN
gs-3799	90	19	,	,	PUNCT
gs-3799	90	20	clinical	clinical	ADJ
gs-3799	90	21	interoperability	interoperability	NOUN
gs-3799	90	22	,	,	PUNCT
gs-3799	90	23	and	and	CCONJ
gs-3799	90	24	regulatory	regulatory	ADJ
gs-3799	90	25	oversight	oversight	NOUN
gs-3799	90	26	.	.	PUNCT
gs-3799	91	1	from	from	ADP
gs-3799	91	2	a	a	DET
gs-3799	91	3	clinical	clinical	ADJ
gs-3799	91	4	perspective	perspective	NOUN
gs-3799	91	5	,	,	PUNCT
gs-3799	91	6	the	the	DET
gs-3799	91	7	benefits	benefit	NOUN
gs-3799	91	8	of	of	ADP
gs-3799	91	9	closed	closed	ADJ
gs-3799	91	10	-	-	PUNCT
gs-3799	91	11	loop	loop	NOUN
gs-3799	91	12	cpb	cpb	PROPN
gs-3799	91	13	systems	system	NOUN
gs-3799	91	14	are	be	AUX
gs-3799	91	15	increasingly	increasingly	ADV
gs-3799	91	16	evident	evident	ADJ
gs-3799	91	17	.	.	PUNCT
gs-3799	92	1	studies	study	NOUN
gs-3799	92	2	have	have	AUX
gs-3799	92	3	demonstrated	demonstrate	VERB
gs-3799	92	4	that	that	SCONJ
gs-3799	92	5	these	these	DET
gs-3799	92	6	systems	system	NOUN
gs-3799	92	7	contribute	contribute	VERB
gs-3799	92	8	to	to	ADP
gs-3799	92	9	more	more	ADV
gs-3799	92	10	stable	stable	ADJ
gs-3799	92	11	hemodynamics	hemodynamic	NOUN
gs-3799	92	12	,	,	PUNCT
gs-3799	92	13	fewer	few	ADJ
gs-3799	92	14	fluctuations	fluctuation	NOUN
gs-3799	92	15	in	in	ADP
gs-3799	92	16	oxygenation	oxygenation	NOUN
gs-3799	92	17	and	and	CCONJ
gs-3799	92	18	acid	acid	NOUN
gs-3799	92	19	-	-	PUNCT
gs-3799	92	20	base	base	NOUN
gs-3799	92	21	status	status	NOUN
gs-3799	92	22	,	,	PUNCT
gs-3799	92	23	and	and	CCONJ
gs-3799	92	24	decreased	decrease	VERB
gs-3799	92	25	need	need	NOUN
gs-3799	92	26	for	for	ADP
gs-3799	92	27	blood	blood	NOUN
gs-3799	92	28	transfusions	transfusion	NOUN
gs-3799	92	29	.	.	PUNCT
gs-3799	93	1	furthermore	furthermore	ADV
gs-3799	93	2	,	,	PUNCT
gs-3799	93	3	by	by	ADP
gs-3799	93	4	automating	automate	VERB
gs-3799	93	5	routine	routine	ADJ
gs-3799	93	6	adjustments	adjustment	NOUN
gs-3799	93	7	,	,	PUNCT
gs-3799	93	8	they	they	PRON
gs-3799	93	9	allow	allow	VERB
gs-3799	93	10	perfusionists	perfusionist	NOUN
gs-3799	93	11	and	and	CCONJ
gs-3799	93	12	anesthesiologists	anesthesiologist	NOUN
gs-3799	93	13	to	to	PART
gs-3799	93	14	focus	focus	VERB
gs-3799	93	15	more	more	ADV
gs-3799	93	16	on	on	ADP
gs-3799	93	17	critical	critical	ADJ
gs-3799	93	18	decision	decision	NOUN
gs-3799	93	19	-	-	PUNCT
gs-3799	93	20	making	make	VERB
gs-3799	93	21	and	and	CCONJ
gs-3799	93	22	patient	patient	NOUN
gs-3799	93	23	-	-	PUNCT
gs-3799	93	24	specific	specific	ADJ
gs-3799	93	25	nuances	nuance	NOUN
gs-3799	93	26	.	.	PUNCT
gs-3799	94	1	these	these	DET
gs-3799	94	2	advantages	advantage	NOUN
gs-3799	94	3	are	be	AUX
gs-3799	94	4	particularly	particularly	ADV
gs-3799	94	5	pronounced	pronounce	VERB
gs-3799	94	6	in	in	ADP
gs-3799	94	7	high	high	ADJ
gs-3799	94	8	-	-	PUNCT
gs-3799	94	9	risk	risk	NOUN
gs-3799	94	10	populations	population	NOUN
gs-3799	94	11	such	such	ADJ
gs-3799	94	12	as	as	ADP
gs-3799	94	13	neonates	neonate	NOUN
gs-3799	94	14	,	,	PUNCT
gs-3799	94	15	elderly	elderly	ADJ
gs-3799	94	16	patients	patient	NOUN
gs-3799	94	17	,	,	PUNCT
gs-3799	94	18	and	and	CCONJ
gs-3799	94	19	individuals	individual	NOUN
gs-3799	94	20	with	with	ADP
gs-3799	94	21	significant	significant	ADJ
gs-3799	94	22	comorbidities	comorbiditie	NOUN
gs-3799	94	23	,	,	PUNCT
gs-3799	94	24	for	for	ADP
gs-3799	94	25	whom	whom	PRON
gs-3799	94	26	physiological	physiological	ADJ
gs-3799	94	27	margins	margin	NOUN
gs-3799	94	28	are	be	AUX
gs-3799	94	29	narrow	narrow	ADJ
gs-3799	94	30	and	and	CCONJ
gs-3799	94	31	deviations	deviation	NOUN
gs-3799	94	32	from	from	ADP
gs-3799	94	33	homeostasis	homeostasis	NOUN
gs-3799	94	34	carry	carry	VERB
gs-3799	94	35	serious	serious	ADJ
gs-3799	94	36	risks	risk	NOUN
gs-3799	94	37	.	.	PUNCT
gs-3799	95	1	the	the	DET
gs-3799	95	2	adoption	adoption	NOUN
gs-3799	95	3	of	of	ADP
gs-3799	95	4	closed	closed	ADJ
gs-3799	95	5	-	-	PUNCT
gs-3799	95	6	loop	loop	NOUN
gs-3799	95	7	systems	system	NOUN
gs-3799	95	8	also	also	ADV
gs-3799	95	9	has	have	VERB
gs-3799	95	10	implications	implication	NOUN
gs-3799	95	11	for	for	ADP
gs-3799	95	12	the	the	DET
gs-3799	95	13	training	training	NOUN
gs-3799	95	14	and	and	CCONJ
gs-3799	95	15	roles	role	NOUN
gs-3799	95	16	of	of	ADP
gs-3799	95	17	surgical	surgical	ADJ
gs-3799	95	18	team	team	NOUN
gs-3799	95	19	members	member	NOUN
gs-3799	95	20	.	.	PUNCT
gs-3799	96	1	perfusionists	perfusionist	NOUN
gs-3799	96	2	,	,	PUNCT
gs-3799	96	3	for	for	ADP
gs-3799	96	4	example	example	NOUN
gs-3799	96	5	,	,	PUNCT
gs-3799	96	6	must	must	AUX
gs-3799	96	7	acquire	acquire	VERB
gs-3799	96	8	new	new	ADJ
gs-3799	96	9	competencies	competency	NOUN
gs-3799	96	10	in	in	ADP
gs-3799	96	11	interpreting	interpret	VERB
gs-3799	96	12	complex	complex	ADJ
gs-3799	96	13	data	datum	NOUN
gs-3799	96	14	streams	stream	NOUN
gs-3799	96	15	,	,	PUNCT
gs-3799	96	16	interacting	interact	VERB
gs-3799	96	17	with	with	ADP
gs-3799	96	18	algorithmic	algorithmic	ADJ
gs-3799	96	19	interfaces	interface	NOUN
gs-3799	96	20	,	,	PUNCT
gs-3799	96	21	and	and	CCONJ
gs-3799	96	22	troubleshooting	troubleshoot	VERB
gs-3799	96	23	automated	automate	VERB
gs-3799	96	24	systems	system	NOUN
gs-3799	96	25	.	.	PUNCT
gs-3799	97	1	this	this	DET
gs-3799	97	2	shift	shift	NOUN
gs-3799	97	3	calls	call	VERB
gs-3799	97	4	for	for	ADP
gs-3799	97	5	revised	revise	VERB
gs-3799	97	6	curricula	curricula	NOUN
gs-3799	97	7	in	in	ADP
gs-3799	97	8	perfusion	perfusion	NOUN
gs-3799	97	9	education	education	NOUN
gs-3799	97	10	,	,	PUNCT
gs-3799	97	11	as	as	ADV
gs-3799	97	12	well	well	ADV
gs-3799	97	13	as	as	ADP
gs-3799	97	14	interdisciplinary	interdisciplinary	ADJ
gs-3799	97	15	collaboration	collaboration	NOUN
gs-3799	97	16	with	with	ADP
gs-3799	97	17	biomedical	biomedical	ADJ
gs-3799	97	18	engineers	engineer	NOUN
gs-3799	97	19	and	and	CCONJ
gs-3799	97	20	data	datum	NOUN
gs-3799	97	21	scientists	scientist	NOUN
gs-3799	97	22	.	.	PUNCT
gs-3799	98	1	furthermore	furthermore	ADV
gs-3799	98	2	,	,	PUNCT
gs-3799	98	3	the	the	DET
gs-3799	98	4	use	use	NOUN
gs-3799	98	5	of	of	ADP
gs-3799	98	6	autonomous	autonomous	ADJ
gs-3799	98	7	or	or	CCONJ
gs-3799	98	8	semi	semi	ADJ
gs-3799	98	9	-	-	ADJ
gs-3799	98	10	autonomous	autonomous	ADJ
gs-3799	98	11	technologies	technology	NOUN
gs-3799	98	12	in	in	ADP
gs-3799	98	13	critical	critical	ADJ
gs-3799	98	14	care	care	NOUN
gs-3799	98	15	environments	environment	NOUN
gs-3799	98	16	raises	raise	VERB
gs-3799	98	17	ethical	ethical	ADJ
gs-3799	98	18	questions	question	NOUN
gs-3799	98	19	regarding	regard	VERB
gs-3799	98	20	responsibility	responsibility	NOUN
gs-3799	98	21	,	,	PUNCT
gs-3799	98	22	oversight	oversight	NOUN
gs-3799	98	23	,	,	PUNCT
gs-3799	98	24	and	and	CCONJ
gs-3799	98	25	the	the	DET
gs-3799	98	26	balance	balance	NOUN
gs-3799	98	27	between	between	ADP
gs-3799	98	28	human	human	ADJ
gs-3799	98	29	and	and	CCONJ
gs-3799	98	30	machine	machine	NOUN
gs-3799	98	31	roles	role	NOUN
gs-3799	98	32	in	in	ADP
gs-3799	98	33	patient	patient	ADJ
gs-3799	98	34	management	management	NOUN
gs-3799	98	35	.	.	PUNCT
gs-3799	99	1	from	from	ADP
gs-3799	99	2	an	an	DET
gs-3799	99	3	innovation	innovation	NOUN
gs-3799	99	4	standpoint	standpoint	NOUN
gs-3799	99	5	,	,	PUNCT
gs-3799	99	6	the	the	DET
gs-3799	99	7	development	development	NOUN
gs-3799	99	8	of	of	ADP
gs-3799	99	9	closed	closed	ADJ
gs-3799	99	10	-	-	PUNCT
gs-3799	99	11	loop	loop	NOUN
gs-3799	99	12	cpb	cpb	NOUN
gs-3799	99	13	systems	system	NOUN
gs-3799	99	14	is	be	AUX
gs-3799	99	15	a	a	DET
gs-3799	99	16	multidisciplinary	multidisciplinary	ADJ
gs-3799	99	17	endeavor	endeavor	NOUN
gs-3799	99	18	.	.	PUNCT
gs-3799	100	1	engineers	engineer	NOUN
gs-3799	100	2	,	,	PUNCT
gs-3799	100	3	clinicians	clinician	NOUN
gs-3799	100	4	,	,	PUNCT
gs-3799	100	5	data	datum	NOUN
gs-3799	100	6	scientists	scientist	NOUN
gs-3799	100	7	,	,	PUNCT
gs-3799	100	8	and	and	CCONJ
gs-3799	100	9	regulatory	regulatory	ADJ
gs-3799	100	10	experts	expert	NOUN
gs-3799	100	11	must	must	AUX
gs-3799	100	12	work	work	VERB
gs-3799	100	13	collaboratively	collaboratively	ADV
gs-3799	100	14	to	to	ADP
gs-3799	100	15	design	design	NOUN
gs-3799	100	16	,	,	PUNCT
gs-3799	100	17	test	test	NOUN
gs-3799	100	18	,	,	PUNCT
gs-3799	100	19	and	and	CCONJ
gs-3799	100	20	refine	refine	VERB
gs-3799	100	21	these	these	DET
gs-3799	100	22	systems	system	NOUN
gs-3799	100	23	.	.	PUNCT
gs-3799	101	1	the	the	DET
gs-3799	101	2	process	process	NOUN
gs-3799	101	3	involves	involve	VERB
gs-3799	101	4	not	not	PART
gs-3799	101	5	only	only	ADV
gs-3799	101	6	technical	technical	ADJ
gs-3799	101	7	georgian	georgian	NOUN
gs-3799	101	8	scientists/	scientists/	NUM
gs-3799	101	9	.	.	PUNCT
gs-3799	102	1	7	7	NUM
gs-3799	102	2	n	n	DET
gs-3799	102	3	2	2	NUM
gs-3799	102	4	,	,	PUNCT
gs-3799	102	5	2025	2025	NUM
gs-3799	102	6	386	386	NUM
gs-3799	102	7	challenges	challenge	NOUN
gs-3799	102	8	but	but	CCONJ
gs-3799	102	9	also	also	ADV
gs-3799	102	10	the	the	DET
gs-3799	102	11	alignment	alignment	NOUN
gs-3799	102	12	of	of	ADP
gs-3799	102	13	diverse	diverse	ADJ
gs-3799	102	14	priorities	priority	NOUN
gs-3799	102	15	and	and	CCONJ
gs-3799	102	16	standards	standard	NOUN
gs-3799	102	17	.	.	PUNCT
gs-3799	103	1	moreover	moreover	ADV
gs-3799	103	2	,	,	PUNCT
gs-3799	103	3	translational	translational	ADJ
gs-3799	103	4	research	research	NOUN
gs-3799	103	5	is	be	AUX
gs-3799	103	6	needed	need	VERB
gs-3799	103	7	to	to	PART
gs-3799	103	8	bridge	bridge	VERB
gs-3799	103	9	the	the	DET
gs-3799	103	10	gap	gap	NOUN
gs-3799	103	11	between	between	ADP
gs-3799	103	12	laboratory	laboratory	NOUN
gs-3799	103	13	prototypes	prototype	NOUN
gs-3799	103	14	and	and	CCONJ
gs-3799	103	15	clinical	clinical	ADJ
gs-3799	103	16	applications	application	NOUN
gs-3799	103	17	,	,	PUNCT
gs-3799	103	18	ensuring	ensure	VERB
gs-3799	103	19	that	that	SCONJ
gs-3799	103	20	novel	novel	ADJ
gs-3799	103	21	technologies	technology	NOUN
gs-3799	103	22	are	be	AUX
gs-3799	103	23	safe	safe	ADJ
gs-3799	103	24	,	,	PUNCT
gs-3799	103	25	reliable	reliable	ADJ
gs-3799	103	26	,	,	PUNCT
gs-3799	103	27	and	and	CCONJ
gs-3799	103	28	effective	effective	ADJ
gs-3799	103	29	in	in	ADP
gs-3799	103	30	real	real	ADJ
gs-3799	103	31	-	-	PUNCT
gs-3799	103	32	world	world	NOUN
gs-3799	103	33	settings	setting	NOUN
gs-3799	103	34	.	.	PUNCT
gs-3799	104	1	the	the	DET
gs-3799	104	2	regulatory	regulatory	ADJ
gs-3799	104	3	landscape	landscape	NOUN
gs-3799	104	4	is	be	AUX
gs-3799	104	5	another	another	DET
gs-3799	104	6	important	important	ADJ
gs-3799	104	7	consideration	consideration	NOUN
gs-3799	104	8	in	in	ADP
gs-3799	104	9	the	the	DET
gs-3799	104	10	deployment	deployment	NOUN
gs-3799	104	11	of	of	ADP
gs-3799	104	12	closed	closed	ADJ
gs-3799	104	13	-	-	PUNCT
gs-3799	104	14	loop	loop	NOUN
gs-3799	104	15	cpb	cpb	PROPN
gs-3799	104	16	systems	system	NOUN
gs-3799	104	17	.	.	PUNCT
gs-3799	105	1	given	give	VERB
gs-3799	105	2	the	the	DET
gs-3799	105	3	complexity	complexity	NOUN
gs-3799	105	4	and	and	CCONJ
gs-3799	105	5	novelty	novelty	NOUN
gs-3799	105	6	of	of	ADP
gs-3799	105	7	these	these	DET
gs-3799	105	8	technologies	technology	NOUN
gs-3799	105	9	,	,	PUNCT
gs-3799	105	10	traditional	traditional	ADJ
gs-3799	105	11	approval	approval	NOUN
gs-3799	105	12	pathways	pathway	NOUN
gs-3799	105	13	may	may	AUX
gs-3799	105	14	be	be	AUX
gs-3799	105	15	insufficient	insufficient	ADJ
gs-3799	105	16	or	or	CCONJ
gs-3799	105	17	ill	ill	ADV
gs-3799	105	18	-	-	PUNCT
gs-3799	105	19	suited	suit	VERB
gs-3799	105	20	.	.	PUNCT
gs-3799	106	1	regulatory	regulatory	ADJ
gs-3799	106	2	bodies	body	NOUN
gs-3799	106	3	such	such	ADJ
gs-3799	106	4	as	as	ADP
gs-3799	106	5	the	the	DET
gs-3799	106	6	u.s	u.s	PROPN
gs-3799	106	7	.	.	PROPN
gs-3799	106	8	food	food	PROPN
gs-3799	106	9	and	and	CCONJ
gs-3799	106	10	drug	drug	PROPN
gs-3799	106	11	administration	administration	PROPN
gs-3799	106	12	(	(	PUNCT
gs-3799	106	13	fda	fda	PROPN
gs-3799	106	14	)	)	PUNCT
gs-3799	106	15	and	and	CCONJ
gs-3799	106	16	the	the	DET
gs-3799	106	17	european	european	PROPN
gs-3799	106	18	medicines	medicines	PROPN
gs-3799	106	19	agency	agency	NOUN
gs-3799	106	20	(	(	PUNCT
gs-3799	106	21	ema	ema	PROPN
gs-3799	106	22	)	)	PUNCT
gs-3799	106	23	are	be	AUX
gs-3799	106	24	beginning	begin	VERB
gs-3799	106	25	to	to	PART
gs-3799	106	26	develop	develop	VERB
gs-3799	106	27	frameworks	framework	NOUN
gs-3799	106	28	for	for	ADP
gs-3799	106	29	evaluating	evaluate	VERB
gs-3799	106	30	ai	ai	ADJ
gs-3799	106	31	-	-	PUNCT
gs-3799	106	32	driven	drive	VERB
gs-3799	106	33	medical	medical	ADJ
gs-3799	106	34	devices	device	NOUN
gs-3799	106	35	and	and	CCONJ
gs-3799	106	36	automated	automate	VERB
gs-3799	106	37	systems	system	NOUN
gs-3799	106	38	,	,	PUNCT
gs-3799	106	39	but	but	CCONJ
gs-3799	106	40	comprehensive	comprehensive	ADJ
gs-3799	106	41	guidelines	guideline	NOUN
gs-3799	106	42	for	for	ADP
gs-3799	106	43	closed	closed	ADJ
gs-3799	106	44	-	-	PUNCT
gs-3799	106	45	loop	loop	NOUN
gs-3799	106	46	extracorporeal	extracorporeal	NOUN
gs-3799	106	47	circulation	circulation	NOUN
gs-3799	106	48	remain	remain	VERB
gs-3799	106	49	in	in	ADP
gs-3799	106	50	development	development	NOUN
gs-3799	106	51	.	.	PUNCT
gs-3799	107	1	ensuring	ensure	VERB
gs-3799	107	2	compliance	compliance	NOUN
gs-3799	107	3	with	with	ADP
gs-3799	107	4	evolving	evolve	VERB
gs-3799	107	5	regulatory	regulatory	ADJ
gs-3799	107	6	standards	standard	NOUN
gs-3799	107	7	is	be	AUX
gs-3799	107	8	essential	essential	ADJ
gs-3799	107	9	to	to	ADP
gs-3799	107	10	the	the	DET
gs-3799	107	11	widespread	widespread	ADJ
gs-3799	107	12	adoption	adoption	NOUN
gs-3799	107	13	of	of	ADP
gs-3799	107	14	these	these	DET
gs-3799	107	15	systems	system	NOUN
gs-3799	107	16	.	.	PUNCT
gs-3799	108	1	closed	close	VERB
gs-3799	108	2	-	-	PUNCT
gs-3799	108	3	loop	loop	NOUN
gs-3799	108	4	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	108	5	bypass	bypass	NOUN
gs-3799	108	6	systems	system	NOUN
gs-3799	108	7	with	with	ADP
gs-3799	108	8	real	real	ADJ
gs-3799	108	9	-	-	PUNCT
gs-3799	108	10	time	time	NOUN
gs-3799	108	11	monitoring	monitoring	NOUN
gs-3799	108	12	and	and	CCONJ
gs-3799	108	13	integrated	integrate	VERB
gs-3799	108	14	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	108	15	represent	represent	VERB
gs-3799	108	16	a	a	DET
gs-3799	108	17	major	major	ADJ
gs-3799	108	18	innovation	innovation	NOUN
gs-3799	108	19	in	in	ADP
gs-3799	108	20	cardiovascular	cardiovascular	ADJ
gs-3799	108	21	medicine	medicine	NOUN
gs-3799	108	22	.	.	PUNCT
gs-3799	109	1	their	their	PRON
gs-3799	109	2	capacity	capacity	NOUN
gs-3799	109	3	to	to	PART
gs-3799	109	4	automate	automate	VERB
gs-3799	109	5	complex	complex	ADJ
gs-3799	109	6	physiological	physiological	ADJ
gs-3799	109	7	management	management	NOUN
gs-3799	109	8	,	,	PUNCT
gs-3799	109	9	respond	respond	VERB
gs-3799	109	10	dynamically	dynamically	ADV
gs-3799	109	11	to	to	ADP
gs-3799	109	12	changing	change	VERB
gs-3799	109	13	conditions	condition	NOUN
gs-3799	109	14	,	,	PUNCT
gs-3799	109	15	and	and	CCONJ
gs-3799	109	16	deliver	deliver	VERB
gs-3799	109	17	individualized	individualized	ADJ
gs-3799	109	18	care	care	NOUN
gs-3799	109	19	holds	hold	VERB
gs-3799	109	20	the	the	DET
gs-3799	109	21	potential	potential	NOUN
gs-3799	109	22	to	to	PART
gs-3799	109	23	transform	transform	VERB
gs-3799	109	24	surgical	surgical	ADJ
gs-3799	109	25	outcomes	outcome	NOUN
gs-3799	109	26	and	and	CCONJ
gs-3799	109	27	redefine	redefine	VERB
gs-3799	109	28	the	the	DET
gs-3799	109	29	standards	standard	NOUN
gs-3799	109	30	of	of	ADP
gs-3799	109	31	extracorporeal	extracorporeal	NOUN
gs-3799	109	32	support	support	NOUN
gs-3799	109	33	.	.	PUNCT
gs-3799	110	1	this	this	DET
gs-3799	110	2	introduction	introduction	NOUN
gs-3799	110	3	provides	provide	VERB
gs-3799	110	4	the	the	DET
gs-3799	110	5	conceptual	conceptual	ADJ
gs-3799	110	6	and	and	CCONJ
gs-3799	110	7	clinical	clinical	ADJ
gs-3799	110	8	groundwork	groundwork	NOUN
gs-3799	110	9	for	for	ADP
gs-3799	110	10	a	a	DET
gs-3799	110	11	comprehensive	comprehensive	ADJ
gs-3799	110	12	exploration	exploration	NOUN
gs-3799	110	13	of	of	ADP
gs-3799	110	14	the	the	DET
gs-3799	110	15	features	feature	NOUN
gs-3799	110	16	,	,	PUNCT
gs-3799	110	17	outcomes	outcome	NOUN
gs-3799	110	18	,	,	PUNCT
gs-3799	110	19	and	and	CCONJ
gs-3799	110	20	future	future	ADJ
gs-3799	110	21	directions	direction	NOUN
gs-3799	110	22	of	of	ADP
gs-3799	110	23	these	these	DET
gs-3799	110	24	advanced	advanced	ADJ
gs-3799	110	25	technologies	technology	NOUN
gs-3799	110	26	.	.	PUNCT
gs-3799	111	1	the	the	DET
gs-3799	111	2	following	follow	VERB
gs-3799	111	3	sections	section	NOUN
gs-3799	111	4	will	will	AUX
gs-3799	111	5	delve	delve	VERB
gs-3799	111	6	into	into	ADP
gs-3799	111	7	the	the	DET
gs-3799	111	8	specific	specific	ADJ
gs-3799	111	9	components	component	NOUN
gs-3799	111	10	,	,	PUNCT
gs-3799	111	11	clinical	clinical	ADJ
gs-3799	111	12	applications	application	NOUN
gs-3799	111	13	,	,	PUNCT
gs-3799	111	14	challenges	challenge	NOUN
gs-3799	111	15	,	,	PUNCT
gs-3799	111	16	and	and	CCONJ
gs-3799	111	17	prospects	prospect	NOUN
gs-3799	111	18	of	of	ADP
gs-3799	111	19	this	this	DET
gs-3799	111	20	rapidly	rapidly	ADV
gs-3799	111	21	evolving	evolve	VERB
gs-3799	111	22	field	field	NOUN
gs-3799	111	23	.	.	PUNCT
gs-3799	112	1	the	the	DET
gs-3799	112	2	intricate	intricate	ADJ
gs-3799	112	3	ballet	ballet	NOUN
gs-3799	112	4	of	of	ADP
gs-3799	112	5	cardiac	cardiac	ADJ
gs-3799	112	6	surgery	surgery	NOUN
gs-3799	112	7	hinges	hinge	NOUN
gs-3799	112	8	precariously	precariously	ADV
gs-3799	112	9	on	on	ADP
gs-3799	112	10	the	the	DET
gs-3799	112	11	artificial	artificial	ADJ
gs-3799	112	12	life	life	NOUN
gs-3799	112	13	support	support	NOUN
gs-3799	112	14	provided	provide	VERB
gs-3799	112	15	by	by	ADP
gs-3799	112	16	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	112	17	bypass	bypass	NOUN
gs-3799	112	18	(	(	PUNCT
gs-3799	112	19	cpb	cpb	NOUN
gs-3799	112	20	)	)	PUNCT
gs-3799	112	21	.	.	PUNCT
gs-3799	113	1	for	for	ADP
gs-3799	113	2	decades	decade	NOUN
gs-3799	113	3	,	,	PUNCT
gs-3799	113	4	managing	manage	VERB
gs-3799	113	5	this	this	DET
gs-3799	113	6	complex	complex	ADJ
gs-3799	113	7	physiological	physiological	ADJ
gs-3799	113	8	substitution	substitution	NOUN
gs-3799	113	9	has	have	AUX
gs-3799	113	10	relied	rely	VERB
gs-3799	113	11	heavily	heavily	ADV
gs-3799	113	12	on	on	ADP
gs-3799	113	13	the	the	DET
gs-3799	113	14	vigilant	vigilant	ADJ
gs-3799	113	15	,	,	PUNCT
gs-3799	113	16	yet	yet	ADV
gs-3799	113	17	inherently	inherently	ADV
gs-3799	113	18	limited	limited	ADJ
gs-3799	113	19	,	,	PUNCT
gs-3799	113	20	human	human	ADJ
gs-3799	113	21	interpretation	interpretation	NOUN
gs-3799	113	22	of	of	ADP
gs-3799	113	23	intermittent	intermittent	ADJ
gs-3799	113	24	data	datum	NOUN
gs-3799	113	25	and	and	CCONJ
gs-3799	113	26	manual	manual	ADJ
gs-3799	113	27	adjustments	adjustment	NOUN
gs-3799	113	28	.	.	PUNCT
gs-3799	114	1	the	the	DET
gs-3799	114	2	emergence	emergence	NOUN
gs-3799	114	3	of	of	ADP
gs-3799	114	4	closed	closed	ADJ
gs-3799	114	5	-	-	PUNCT
gs-3799	114	6	loop	loop	NOUN
gs-3799	114	7	cpb	cpb	PROPN
gs-3799	114	8	systems	system	NOUN
gs-3799	114	9	,	,	PUNCT
gs-3799	114	10	dynamically	dynamically	ADV
gs-3799	114	11	integrating	integrate	VERB
gs-3799	114	12	sophisticated	sophisticated	ADJ
gs-3799	114	13	real	real	ADJ
gs-3799	114	14	-	-	PUNCT
gs-3799	114	15	time	time	NOUN
gs-3799	114	16	multimodal	multimodal	NOUN
gs-3799	114	17	monitoring	monitoring	NOUN
gs-3799	114	18	with	with	ADP
gs-3799	114	19	automated	automate	VERB
gs-3799	114	20	,	,	PUNCT
gs-3799	114	21	algorithm	algorithm	NOUN
gs-3799	114	22	-	-	PUNCT
gs-3799	114	23	driven	drive	VERB
gs-3799	114	24	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	114	25	interventions	intervention	NOUN
gs-3799	114	26	,	,	PUNCT
gs-3799	114	27	represents	represent	VERB
gs-3799	114	28	not	not	PART
gs-3799	114	29	merely	merely	ADV
gs-3799	114	30	an	an	DET
gs-3799	114	31	incremental	incremental	ADJ
gs-3799	114	32	improvement	improvement	NOUN
gs-3799	114	33	,	,	PUNCT
gs-3799	114	34	but	but	CCONJ
gs-3799	114	35	a	a	DET
gs-3799	114	36	potential	potential	ADJ
gs-3799	114	37	paradigm	paradigm	NOUN
gs-3799	114	38	shift	shift	NOUN
gs-3799	114	39	fraught	fraught	ADV
gs-3799	114	40	with	with	ADP
gs-3799	114	41	both	both	CCONJ
gs-3799	114	42	extraordinary	extraordinary	ADJ
gs-3799	114	43	promise	promise	NOUN
gs-3799	114	44	and	and	CCONJ
gs-3799	114	45	profound	profound	ADJ
gs-3799	114	46	challenge	challenge	NOUN
gs-3799	114	47	.	.	PUNCT
gs-3799	115	1	this	this	DET
gs-3799	115	2	convergence	convergence	NOUN
gs-3799	115	3	of	of	ADP
gs-3799	115	4	precision	precision	NOUN
gs-3799	115	5	engineering	engineering	NOUN
gs-3799	115	6	,	,	PUNCT
gs-3799	115	7	advanced	advanced	ADJ
gs-3799	115	8	biocomputing	biocomputing	NOUN
gs-3799	115	9	,	,	PUNCT
gs-3799	115	10	and	and	CCONJ
gs-3799	115	11	pharmacodynamics	pharmacodynamic	NOUN
gs-3799	115	12	aims	aim	VERB
gs-3799	115	13	to	to	PART
gs-3799	115	14	transcend	transcend	VERB
gs-3799	115	15	human	human	ADJ
gs-3799	115	16	reaction	reaction	NOUN
gs-3799	115	17	times	time	NOUN
gs-3799	115	18	and	and	CCONJ
gs-3799	115	19	cognitive	cognitive	ADJ
gs-3799	115	20	biases	bias	NOUN
gs-3799	115	21	,	,	PUNCT
gs-3799	115	22	promising	promise	VERB
gs-3799	115	23	unprecedented	unprecedented	ADJ
gs-3799	115	24	hemodynamic	hemodynamic	ADJ
gs-3799	115	25	stability	stability	NOUN
gs-3799	115	26	,	,	PUNCT
gs-3799	115	27	optimized	optimize	VERB
gs-3799	115	28	organ	organ	NOUN
gs-3799	115	29	protection	protection	NOUN
gs-3799	115	30	,	,	PUNCT
gs-3799	115	31	and	and	CCONJ
gs-3799	115	32	personalized	personalize	VERB
gs-3799	115	33	intraoperative	intraoperative	ADJ
gs-3799	115	34	care	care	NOUN
gs-3799	115	35	.	.	PUNCT
gs-3799	116	1	however	however	ADV
gs-3799	116	2	,	,	PUNCT
gs-3799	116	3	realizing	realize	VERB
gs-3799	116	4	this	this	DET
gs-3799	116	5	vision	vision	NOUN
gs-3799	116	6	demands	demand	NOUN
gs-3799	116	7	navigating	navigate	VERB
gs-3799	116	8	a	a	DET
gs-3799	116	9	labyrinth	labyrinth	NOUN
gs-3799	116	10	of	of	ADP
gs-3799	116	11	technical	technical	ADJ
gs-3799	116	12	complexity	complexity	NOUN
gs-3799	116	13	,	,	PUNCT
gs-3799	116	14	rigorous	rigorous	ADJ
gs-3799	116	15	validation	validation	NOUN
gs-3799	116	16	,	,	PUNCT
gs-3799	116	17	and	and	CCONJ
gs-3799	116	18	fundamental	fundamental	ADJ
gs-3799	116	19	questions	question	NOUN
gs-3799	116	20	about	about	ADP
gs-3799	116	21	autonomy	autonomy	NOUN
gs-3799	116	22	,	,	PUNCT
gs-3799	116	23	safety	safety	NOUN
gs-3799	116	24	boundaries	boundary	NOUN
gs-3799	116	25	,	,	PUNCT
gs-3799	116	26	and	and	CCONJ
gs-3799	116	27	the	the	DET
gs-3799	116	28	evolving	evolve	VERB
gs-3799	116	29	role	role	NOUN
gs-3799	116	30	of	of	ADP
gs-3799	116	31	the	the	DET
gs-3799	116	32	perfusionist	perfusionist	NOUN
gs-3799	116	33	.	.	PUNCT
gs-3799	117	1	understanding	understand	VERB
gs-3799	117	2	the	the	DET
gs-3799	117	3	features	feature	NOUN
gs-3799	117	4	driving	drive	VERB
gs-3799	117	5	these	these	DET
gs-3799	117	6	systems	system	NOUN
gs-3799	117	7	—	—	PUNCT
gs-3799	117	8	their	their	PRON
gs-3799	117	9	capacity	capacity	NOUN
gs-3799	117	10	for	for	ADP
gs-3799	117	11	instantaneous	instantaneous	ADJ
gs-3799	117	12	physiological	physiological	ADJ
gs-3799	117	13	feedback	feedback	NOUN
gs-3799	117	14	,	,	PUNCT
gs-3799	117	15	adaptive	adaptive	ADJ
gs-3799	117	16	drug	drug	NOUN
gs-3799	117	17	delivery	delivery	NOUN
gs-3799	117	18	,	,	PUNCT
gs-3799	117	19	and	and	CCONJ
gs-3799	117	20	predictive	predictive	ADJ
gs-3799	117	21	analytics	analytic	NOUN
gs-3799	117	22	—	—	PUNCT
gs-3799	117	23	is	be	AUX
gs-3799	117	24	crucial	crucial	ADJ
gs-3799	117	25	for	for	ADP
gs-3799	117	26	critically	critically	ADV
gs-3799	117	27	evaluating	evaluate	VERB
gs-3799	117	28	their	their	PRON
gs-3799	117	29	current	current	ADJ
gs-3799	117	30	innovations	innovation	NOUN
gs-3799	117	31	,	,	PUNCT
gs-3799	117	32	demonstrable	demonstrable	ADJ
gs-3799	117	33	outcomes	outcome	NOUN
gs-3799	117	34	,	,	PUNCT
gs-3799	117	35	and	and	CCONJ
gs-3799	117	36	the	the	DET
gs-3799	117	37	significant	significant	ADJ
gs-3799	117	38	hurdles	hurdle	NOUN
gs-3799	117	39	shaping	shape	VERB
gs-3799	117	40	their	their	PRON
gs-3799	117	41	future	future	ADJ
gs-3799	117	42	trajectory	trajectory	NOUN
gs-3799	117	43	towards	towards	ADP
gs-3799	117	44	transforming	transform	VERB
gs-3799	117	45	cardiac	cardiac	ADJ
gs-3799	117	46	surgical	surgical	ADJ
gs-3799	117	47	practice	practice	NOUN
gs-3799	117	48	.	.	PUNCT
gs-3799	118	1	the	the	DET
gs-3799	118	2	journey	journey	NOUN
gs-3799	118	3	towards	towards	ADP
gs-3799	118	4	truly	truly	ADV
gs-3799	118	5	autonomous	autonomous	ADJ
gs-3799	118	6	,	,	PUNCT
gs-3799	118	7	intelligent	intelligent	ADJ
gs-3799	118	8	perfusion	perfusion	NOUN
gs-3799	118	9	is	be	AUX
gs-3799	118	10	as	as	ADP
gs-3799	118	11	intellectually	intellectually	ADV
gs-3799	118	12	demanding	demand	VERB
gs-3799	118	13	as	as	SCONJ
gs-3799	118	14	it	it	PRON
gs-3799	118	15	is	be	AUX
gs-3799	118	16	potentially	potentially	ADV
gs-3799	118	17	revolutionary	revolutionary	ADJ
gs-3799	118	18	.	.	PUNCT
gs-3799	119	1	cardiac	cardiac	ADJ
gs-3799	119	2	surgery	surgery	NOUN
gs-3799	119	3	,	,	PUNCT
gs-3799	119	4	a	a	DET
gs-3799	119	5	pinnacle	pinnacle	NOUN
gs-3799	119	6	of	of	ADP
gs-3799	119	7	modern	modern	ADJ
gs-3799	119	8	medicine	medicine	NOUN
gs-3799	119	9	,	,	PUNCT
gs-3799	119	10	remains	remain	VERB
gs-3799	119	11	fundamentally	fundamentally	ADV
gs-3799	119	12	dependent	dependent	ADJ
gs-3799	119	13	on	on	ADP
gs-3799	119	14	the	the	DET
gs-3799	119	15	precarious	precarious	ADJ
gs-3799	119	16	art	art	NOUN
gs-3799	119	17	of	of	ADP
gs-3799	119	18	artificial	artificial	ADJ
gs-3799	119	19	perfusion	perfusion	NOUN
gs-3799	119	20	.	.	PUNCT
gs-3799	120	1	traditional	traditional	ADJ
gs-3799	120	2	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	120	3	bypass	bypass	NOUN
gs-3799	120	4	(	(	PUNCT
gs-3799	120	5	cpb	cpb	NOUN
gs-3799	120	6	)	)	PUNCT
gs-3799	120	7	,	,	PUNCT
gs-3799	120	8	while	while	SCONJ
gs-3799	120	9	life	life	NOUN
gs-3799	120	10	-	-	PUNCT
gs-3799	120	11	sustaining	sustain	VERB
gs-3799	120	12	,	,	PUNCT
gs-3799	120	13	represents	represent	VERB
gs-3799	120	14	a	a	DET
gs-3799	120	15	profound	profound	ADJ
gs-3799	120	16	physiological	physiological	ADJ
gs-3799	120	17	trespass	trespass	NOUN
gs-3799	120	18	.	.	PUNCT
gs-3799	121	1	its	its	PRON
gs-3799	121	2	management	management	NOUN
gs-3799	121	3	–	–	PUNCT
gs-3799	121	4	a	a	DET
gs-3799	121	5	high	high	ADJ
gs-3799	121	6	-	-	PUNCT
gs-3799	121	7	stakes	stake	NOUN
gs-3799	121	8	balancing	balance	VERB
gs-3799	121	9	act	act	NOUN
gs-3799	121	10	of	of	ADP
gs-3799	121	11	hemodynamics	hemodynamic	NOUN
gs-3799	121	12	,	,	PUNCT
gs-3799	121	13	coagulation	coagulation	NOUN
gs-3799	121	14	,	,	PUNCT
gs-3799	121	15	oxygenation	oxygenation	NOUN
gs-3799	121	16	,	,	PUNCT
gs-3799	121	17	and	and	CCONJ
gs-3799	121	18	organ	organ	NOUN
gs-3799	121	19	protection	protection	NOUN
gs-3799	121	20	–	–	PUNCT
gs-3799	121	21	has	have	AUX
gs-3799	121	22	historically	historically	ADV
gs-3799	121	23	rested	rest	VERB
gs-3799	121	24	upon	upon	SCONJ
gs-3799	121	25	the	the	DET
gs-3799	121	26	shoulders	shoulder	NOUN
gs-3799	121	27	of	of	ADP
gs-3799	121	28	the	the	DET
gs-3799	121	29	perfusionist	perfusionist	NOUN
gs-3799	121	30	and	and	CCONJ
gs-3799	121	31	anesthesiologist	anesthesiologist	ADJ
gs-3799	121	32	,	,	PUNCT
gs-3799	121	33	interpreting	interpret	VERB
gs-3799	121	34	fragmented	fragmented	ADJ
gs-3799	121	35	data	datum	NOUN
gs-3799	121	36	streams	stream	NOUN
gs-3799	121	37	and	and	CCONJ
gs-3799	121	38	making	make	VERB
gs-3799	121	39	reactive	reactive	NOUN
gs-3799	121	40	,	,	PUNCT
gs-3799	121	41	often	often	ADV
gs-3799	121	42	delayed	delay	VERB
gs-3799	121	43	,	,	PUNCT
gs-3799	121	44	manual	manual	ADJ
gs-3799	121	45	interventions	intervention	NOUN
gs-3799	121	46	.	.	PUNCT
gs-3799	122	1	this	this	DET
gs-3799	122	2	paradigm	paradigm	NOUN
gs-3799	122	3	,	,	PUNCT
gs-3799	122	4	inherently	inherently	ADV
gs-3799	122	5	constrained	constrain	VERB
gs-3799	122	6	by	by	ADP
gs-3799	122	7	human	human	ADJ
gs-3799	122	8	perception	perception	NOUN
gs-3799	122	9	,	,	PUNCT
gs-3799	122	10	reaction	reaction	NOUN
gs-3799	122	11	time	time	NOUN
gs-3799	122	12	,	,	PUNCT
gs-3799	122	13	and	and	CCONJ
gs-3799	122	14	the	the	DET
gs-3799	122	15	complexity	complexity	NOUN
gs-3799	122	16	of	of	ADP
gs-3799	122	17	multivariate	multivariate	NOUN
gs-3799	122	18	physiological	physiological	ADJ
gs-3799	122	19	interactions	interaction	NOUN
gs-3799	122	20	,	,	PUNCT
gs-3799	122	21	carries	carry	VERB
gs-3799	122	22	an	an	DET
gs-3799	122	23	georgian	georgian	NOUN
gs-3799	122	24	scientists/	scientists/	NUM
gs-3799	122	25	.	.	PUNCT
gs-3799	123	1	7	7	NUM
gs-3799	123	2	n	n	PRON
gs-3799	123	3	2	2	NUM
gs-3799	123	4	,	,	PUNCT
gs-3799	123	5	2025	2025	NUM
gs-3799	123	6	387	387	NUM
gs-3799	123	7	inescapable	inescapable	ADJ
gs-3799	123	8	burden	burden	NOUN
gs-3799	123	9	of	of	ADP
gs-3799	123	10	potential	potential	ADJ
gs-3799	123	11	instability	instability	NOUN
gs-3799	123	12	and	and	CCONJ
gs-3799	123	13	suboptimal	suboptimal	ADJ
gs-3799	123	14	outcomes	outcome	NOUN
gs-3799	123	15	.	.	PUNCT
gs-3799	124	1	the	the	DET
gs-3799	124	2	emergence	emergence	NOUN
gs-3799	124	3	of	of	ADP
gs-3799	124	4	closed	closed	ADJ
gs-3799	124	5	-	-	PUNCT
gs-3799	124	6	loop	loop	NOUN
gs-3799	124	7	cpb	cpb	PROPN
gs-3799	124	8	systems	system	NOUN
gs-3799	124	9	,	,	PUNCT
gs-3799	124	10	however	however	ADV
gs-3799	124	11	,	,	PUNCT
gs-3799	124	12	heralds	herald	VERB
gs-3799	124	13	a	a	DET
gs-3799	124	14	transformative	transformative	ADJ
gs-3799	124	15	ambition	ambition	NOUN
gs-3799	124	16	:	:	PUNCT
gs-3799	124	17	the	the	DET
gs-3799	124	18	creation	creation	NOUN
gs-3799	124	19	of	of	ADP
gs-3799	124	20	autonomous	autonomous	ADJ
gs-3799	124	21	life	life	NOUN
gs-3799	124	22	support	support	NOUN
gs-3799	124	23	.	.	PUNCT
gs-3799	125	1	these	these	DET
gs-3799	125	2	systems	system	NOUN
gs-3799	125	3	aspire	aspire	VERB
gs-3799	125	4	not	not	PART
gs-3799	125	5	merely	merely	ADV
gs-3799	125	6	to	to	PART
gs-3799	125	7	assist	assist	VERB
gs-3799	125	8	,	,	PUNCT
gs-3799	125	9	but	but	CCONJ
gs-3799	125	10	to	to	PART
gs-3799	125	11	intelligently	intelligently	ADV
gs-3799	125	12	orchestrate	orchestrate	VERB
gs-3799	125	13	the	the	DET
gs-3799	125	14	bypass	bypass	NOUN
gs-3799	125	15	environment	environment	NOUN
gs-3799	125	16	by	by	ADP
gs-3799	125	17	seamlessly	seamlessly	ADV
gs-3799	125	18	integrating	integrate	VERB
gs-3799	125	19	continuous	continuous	ADJ
gs-3799	125	20	,	,	PUNCT
gs-3799	125	21	multimodal	multimodal	ADJ
gs-3799	125	22	real	real	ADJ
gs-3799	125	23	-	-	PUNCT
gs-3799	125	24	time	time	NOUN
gs-3799	125	25	monitoring	monitoring	NOUN
gs-3799	125	26	with	with	ADP
gs-3799	125	27	algorithmically	algorithmically	ADV
gs-3799	125	28	driven	drive	VERB
gs-3799	125	29	,	,	PUNCT
gs-3799	125	30	adaptive	adaptive	ADJ
gs-3799	125	31	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	125	32	delivery	delivery	NOUN
gs-3799	125	33	.	.	PUNCT
gs-3799	126	1	this	this	DET
gs-3799	126	2	intricate	intricate	ADJ
gs-3799	126	3	fusion	fusion	NOUN
gs-3799	126	4	of	of	ADP
gs-3799	126	5	advanced	advanced	ADJ
gs-3799	126	6	sensor	sensor	NOUN
gs-3799	126	7	technology	technology	NOUN
gs-3799	126	8	,	,	PUNCT
gs-3799	126	9	sophisticated	sophisticated	ADJ
gs-3799	126	10	biocomputational	biocomputational	ADJ
gs-3799	126	11	logic	logic	NOUN
gs-3799	126	12	,	,	PUNCT
gs-3799	126	13	and	and	CCONJ
gs-3799	126	14	precision	precision	NOUN
gs-3799	126	15	pharmacology	pharmacology	NOUN
gs-3799	126	16	aims	aim	VERB
gs-3799	126	17	to	to	PART
gs-3799	126	18	transcend	transcend	VERB
gs-3799	126	19	human	human	ADJ
gs-3799	126	20	limitations	limitation	NOUN
gs-3799	126	21	,	,	PUNCT
gs-3799	126	22	promising	promise	VERB
gs-3799	126	23	a	a	DET
gs-3799	126	24	new	new	ADJ
gs-3799	126	25	era	era	NOUN
gs-3799	126	26	of	of	ADP
gs-3799	126	27	unprecedented	unprecedented	ADJ
gs-3799	126	28	stability	stability	NOUN
gs-3799	126	29	,	,	PUNCT
gs-3799	126	30	personalized	personalize	VERB
gs-3799	126	31	physiologic	physiologic	ADJ
gs-3799	126	32	control	control	NOUN
gs-3799	126	33	,	,	PUNCT
gs-3799	126	34	and	and	CCONJ
gs-3799	126	35	proactive	proactive	ADJ
gs-3799	126	36	organ	organ	NOUN
gs-3799	126	37	preservation	preservation	NOUN
gs-3799	126	38	.	.	PUNCT
gs-3799	127	1	understanding	understand	VERB
gs-3799	127	2	the	the	DET
gs-3799	127	3	profound	profound	ADJ
gs-3799	127	4	features	feature	NOUN
gs-3799	127	5	enabling	enable	VERB
gs-3799	127	6	this	this	DET
gs-3799	127	7	integration	integration	NOUN
gs-3799	127	8	–	–	PUNCT
gs-3799	127	9	the	the	DET
gs-3799	127	10	relentless	relentless	ADJ
gs-3799	127	11	vigilance	vigilance	NOUN
gs-3799	127	12	of	of	ADP
gs-3799	127	13	real	real	ADJ
gs-3799	127	14	-	-	PUNCT
gs-3799	127	15	time	time	NOUN
gs-3799	127	16	sensing	sensing	NOUN
gs-3799	127	17	,	,	PUNCT
gs-3799	127	18	the	the	DET
gs-3799	127	19	dynamic	dynamic	ADJ
gs-3799	127	20	responsiveness	responsiveness	NOUN
gs-3799	127	21	of	of	ADP
gs-3799	127	22	automated	automate	VERB
gs-3799	127	23	drug	drug	NOUN
gs-3799	127	24	titration	titration	NOUN
gs-3799	127	25	,	,	PUNCT
gs-3799	127	26	and	and	CCONJ
gs-3799	127	27	the	the	DET
gs-3799	127	28	nascent	nascent	ADJ
gs-3799	127	29	potential	potential	NOUN
gs-3799	127	30	for	for	ADP
gs-3799	127	31	predictive	predictive	ADJ
gs-3799	127	32	analytics	analytic	NOUN
gs-3799	127	33	–	–	PUNCT
gs-3799	127	34	is	be	AUX
gs-3799	127	35	paramount	paramount	ADJ
gs-3799	127	36	.	.	PUNCT
gs-3799	128	1	it	it	PRON
gs-3799	128	2	demands	demand	VERB
gs-3799	128	3	a	a	DET
gs-3799	128	4	critical	critical	ADJ
gs-3799	128	5	examination	examination	NOUN
gs-3799	128	6	of	of	ADP
gs-3799	128	7	the	the	DET
gs-3799	128	8	groundbreaking	groundbreake	VERB
gs-3799	128	9	innovations	innovation	NOUN
gs-3799	128	10	fueling	fuel	VERB
gs-3799	128	11	their	their	PRON
gs-3799	128	12	development	development	NOUN
gs-3799	128	13	,	,	PUNCT
gs-3799	128	14	the	the	DET
gs-3799	128	15	tangible	tangible	ADJ
gs-3799	128	16	outcomes	outcome	NOUN
gs-3799	128	17	emerging	emerge	VERB
gs-3799	128	18	from	from	ADP
gs-3799	128	19	their	their	PRON
gs-3799	128	20	clinical	clinical	ADJ
gs-3799	128	21	application	application	NOUN
gs-3799	128	22	,	,	PUNCT
gs-3799	128	23	and	and	CCONJ
gs-3799	128	24	the	the	DET
gs-3799	128	25	formidable	formidable	ADJ
gs-3799	128	26	scientific	scientific	ADJ
gs-3799	128	27	,	,	PUNCT
gs-3799	128	28	technical	technical	ADJ
gs-3799	128	29	,	,	PUNCT
gs-3799	128	30	and	and	CCONJ
gs-3799	128	31	ethical	ethical	ADJ
gs-3799	128	32	challenges	challenge	NOUN
gs-3799	128	33	that	that	PRON
gs-3799	128	34	will	will	AUX
gs-3799	128	35	ultimately	ultimately	ADV
gs-3799	128	36	chart	chart	VERB
gs-3799	128	37	their	their	PRON
gs-3799	128	38	future	future	ADJ
gs-3799	128	39	course	course	NOUN
gs-3799	128	40	.	.	PUNCT
gs-3799	129	1	this	this	DET
gs-3799	129	2	journey	journey	NOUN
gs-3799	129	3	into	into	ADP
gs-3799	129	4	the	the	DET
gs-3799	129	5	heart	heart	NOUN
gs-3799	129	6	of	of	ADP
gs-3799	129	7	intelligent	intelligent	ADJ
gs-3799	129	8	perfusion	perfusion	NOUN
gs-3799	129	9	is	be	AUX
gs-3799	129	10	not	not	PART
gs-3799	129	11	merely	merely	ADV
gs-3799	129	12	an	an	DET
gs-3799	129	13	engineering	engineering	NOUN
gs-3799	129	14	feat	feat	NOUN
gs-3799	129	15	;	;	PUNCT
gs-3799	129	16	it	it	PRON
gs-3799	129	17	is	be	AUX
gs-3799	129	18	a	a	DET
gs-3799	129	19	fundamental	fundamental	ADJ
gs-3799	129	20	reimagining	reimagining	NOUN
gs-3799	129	21	of	of	ADP
gs-3799	129	22	how	how	SCONJ
gs-3799	129	23	we	we	PRON
gs-3799	129	24	sustain	sustain	VERB
gs-3799	129	25	life	life	NOUN
gs-3799	129	26	during	during	ADP
gs-3799	129	27	the	the	DET
gs-3799	129	28	most	most	ADV
gs-3799	129	29	vulnerable	vulnerable	ADJ
gs-3799	129	30	of	of	ADP
gs-3799	129	31	human	human	ADJ
gs-3799	129	32	passages	passage	NOUN
gs-3799	129	33	,	,	PUNCT
gs-3799	129	34	fraught	fraught	ADJ
gs-3799	129	35	with	with	ADP
gs-3799	129	36	immense	immense	ADJ
gs-3799	129	37	promise	promise	NOUN
gs-3799	129	38	yet	yet	ADV
gs-3799	129	39	demanding	demand	VERB
gs-3799	129	40	rigorous	rigorous	ADJ
gs-3799	129	41	navigation	navigation	NOUN
gs-3799	129	42	through	through	ADP
gs-3799	129	43	uncharted	uncharted	ADJ
gs-3799	129	44	physiological	physiological	ADJ
gs-3799	129	45	and	and	CCONJ
gs-3799	129	46	operational	operational	ADJ
gs-3799	129	47	terrain	terrain	NOUN
gs-3799	129	48	.	.	PUNCT
gs-3799	130	1	the	the	DET
gs-3799	130	2	quest	quest	NOUN
gs-3799	130	3	for	for	ADP
gs-3799	130	4	a	a	DET
gs-3799	130	5	truly	truly	ADV
gs-3799	130	6	autonomous	autonomous	ADJ
gs-3799	130	7	bypass	bypass	NOUN
gs-3799	130	8	circuit	circuit	NOUN
gs-3799	130	9	is	be	AUX
gs-3799	130	10	,	,	PUNCT
gs-3799	130	11	at	at	ADP
gs-3799	130	12	its	its	PRON
gs-3799	130	13	core	core	NOUN
gs-3799	130	14	,	,	PUNCT
gs-3799	130	15	a	a	DET
gs-3799	130	16	quest	quest	NOUN
gs-3799	130	17	for	for	ADP
gs-3799	130	18	perfection	perfection	NOUN
gs-3799	130	19	in	in	ADP
gs-3799	130	20	the	the	DET
gs-3799	130	21	imperfect	imperfect	ADJ
gs-3799	130	22	art	art	NOUN
gs-3799	130	23	of	of	ADP
gs-3799	130	24	suspended	suspend	VERB
gs-3799	130	25	animation	animation	NOUN
gs-3799	130	26	.	.	PUNCT
gs-3799	131	1	the	the	DET
gs-3799	131	2	relentless	relentless	ADJ
gs-3799	131	3	pursuit	pursuit	NOUN
gs-3799	131	4	of	of	ADP
gs-3799	131	5	physiological	physiological	ADJ
gs-3799	131	6	fidelity	fidelity	NOUN
gs-3799	131	7	during	during	ADP
gs-3799	131	8	artificial	artificial	ADJ
gs-3799	131	9	circulatory	circulatory	ADJ
gs-3799	131	10	support	support	NOUN
gs-3799	131	11	represents	represent	VERB
gs-3799	131	12	one	one	NUM
gs-3799	131	13	of	of	ADP
gs-3799	131	14	cardiac	cardiac	ADJ
gs-3799	131	15	surgery	surgery	NOUN
gs-3799	131	16	's	's	PART
gs-3799	131	17	most	most	ADV
gs-3799	131	18	formidable	formidable	ADJ
gs-3799	131	19	challenges	challenge	NOUN
gs-3799	131	20	.	.	PUNCT
gs-3799	132	1	traditional	traditional	ADJ
gs-3799	132	2	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	132	3	bypass	bypass	NOUN
gs-3799	132	4	(	(	PUNCT
gs-3799	132	5	cpb	cpb	NOUN
gs-3799	132	6	)	)	PUNCT
gs-3799	132	7	,	,	PUNCT
gs-3799	132	8	while	while	SCONJ
gs-3799	132	9	revolutionary	revolutionary	ADJ
gs-3799	132	10	in	in	ADP
gs-3799	132	11	enabling	enable	VERB
gs-3799	132	12	intracardiac	intracardiac	NOUN
gs-3799	132	13	procedures	procedure	NOUN
gs-3799	132	14	,	,	PUNCT
gs-3799	132	15	remains	remain	VERB
gs-3799	132	16	a	a	DET
gs-3799	132	17	profound	profound	ADJ
gs-3799	132	18	physiological	physiological	ADJ
gs-3799	132	19	trespass	trespass	NOUN
gs-3799	132	20	characterized	characterize	VERB
gs-3799	132	21	by	by	ADP
gs-3799	132	22	non	non	ADJ
gs-3799	132	23	-	-	ADJ
gs-3799	132	24	pulsatile	pulsatile	ADJ
gs-3799	132	25	flow	flow	NOUN
gs-3799	132	26	,	,	PUNCT
gs-3799	132	27	blood	blood	NOUN
gs-3799	132	28	-	-	PUNCT
gs-3799	132	29	artificial	artificial	ADJ
gs-3799	132	30	surface	surface	NOUN
gs-3799	132	31	interactions	interaction	NOUN
gs-3799	132	32	,	,	PUNCT
gs-3799	132	33	and	and	CCONJ
gs-3799	132	34	intermittent	intermittent	ADJ
gs-3799	132	35	monitoring	monitoring	NOUN
gs-3799	132	36	that	that	PRON
gs-3799	132	37	necessitates	necessitate	VERB
gs-3799	132	38	reactive	reactive	ADJ
gs-3799	132	39	human	human	ADJ
gs-3799	132	40	intervention	intervention	NOUN
gs-3799	132	41	.	.	PUNCT
gs-3799	133	1	this	this	DET
gs-3799	133	2	technological	technological	ADJ
gs-3799	133	3	paradigm	paradigm	NOUN
gs-3799	133	4	,	,	PUNCT
gs-3799	133	5	largely	largely	ADV
gs-3799	133	6	unchanged	unchanged	ADJ
gs-3799	133	7	in	in	ADP
gs-3799	133	8	its	its	PRON
gs-3799	133	9	fundamental	fundamental	ADJ
gs-3799	133	10	operation	operation	NOUN
gs-3799	133	11	for	for	ADP
gs-3799	133	12	decades	decade	NOUN
gs-3799	133	13	,	,	PUNCT
gs-3799	133	14	imposes	impose	VERB
gs-3799	133	15	significant	significant	ADJ
gs-3799	133	16	limitations	limitation	NOUN
gs-3799	133	17	:	:	PUNCT
gs-3799	133	18	the	the	DET
gs-3799	133	19	systemic	systemic	ADJ
gs-3799	133	20	inflammatory	inflammatory	ADJ
gs-3799	133	21	response	response	NOUN
gs-3799	133	22	syndrome	syndrome	NOUN
gs-3799	133	23	triggered	trigger	VERB
gs-3799	133	24	by	by	ADP
gs-3799	133	25	blood	blood	NOUN
gs-3799	133	26	-	-	PUNCT
gs-3799	133	27	contact	contact	NOUN
gs-3799	133	28	activation	activation	NOUN
gs-3799	133	29	cascades	cascade	NOUN
gs-3799	133	30	,	,	PUNCT
gs-3799	133	31	hemodilution	hemodilution	NOUN
gs-3799	133	32	from	from	ADP
gs-3799	133	33	priming	prime	VERB
gs-3799	133	34	volumes	volume	NOUN
gs-3799	133	35	exceeding	exceed	VERB
gs-3799	133	36	1,500ml	1,500ml	NOUN
gs-3799	133	37	,	,	PUNCT
gs-3799	133	38	coagulation	coagulation	NOUN
gs-3799	133	39	disturbances	disturbance	NOUN
gs-3799	133	40	,	,	PUNCT
gs-3799	133	41	and	and	CCONJ
gs-3799	133	42	end	end	NOUN
gs-3799	133	43	-	-	PUNCT
gs-3799	133	44	organ	organ	NOUN
gs-3799	133	45	injury	injury	NOUN
gs-3799	133	46	collectively	collectively	ADV
gs-3799	133	47	contribute	contribute	VERB
gs-3799	133	48	to	to	ADP
gs-3799	133	49	what	what	PRON
gs-3799	133	50	is	be	AUX
gs-3799	133	51	termed	term	VERB
gs-3799	133	52	"	"	PUNCT
gs-3799	133	53	postperfusion	postperfusion	NOUN
gs-3799	133	54	syndrome	syndrome	NOUN
gs-3799	133	55	"	"	PUNCT
gs-3799	133	56	.	.	PUNCT
gs-3799	134	1	these	these	DET
gs-3799	134	2	pathophysiological	pathophysiological	ADJ
gs-3799	134	3	consequences	consequence	NOUN
gs-3799	134	4	manifest	manifest	VERB
gs-3799	134	5	clinically	clinically	ADV
gs-3799	134	6	as	as	ADP
gs-3799	134	7	neurocognitive	neurocognitive	ADJ
gs-3799	134	8	decline	decline	NOUN
gs-3799	134	9	,	,	PUNCT
gs-3799	134	10	renal	renal	ADJ
gs-3799	134	11	dysfunction	dysfunction	NOUN
gs-3799	134	12	,	,	PUNCT
gs-3799	134	13	pulmonary	pulmonary	ADJ
gs-3799	134	14	complications	complication	NOUN
gs-3799	134	15	,	,	PUNCT
gs-3799	134	16	and	and	CCONJ
gs-3799	134	17	coagulopathies	coagulopathie	NOUN
gs-3799	134	18	that	that	PRON
gs-3799	134	19	prolong	prolong	VERB
gs-3799	134	20	intensive	intensive	ADJ
gs-3799	134	21	care	care	NOUN
gs-3799	134	22	and	and	CCONJ
gs-3799	134	23	hospital	hospital	NOUN
gs-3799	134	24	stays	stay	NOUN
gs-3799	134	25	despite	despite	SCONJ
gs-3799	134	26	meticulous	meticulous	ADJ
gs-3799	134	27	perfusion	perfusion	NOUN
gs-3799	134	28	management	management	NOUN
gs-3799	134	29	.	.	PUNCT
gs-3799	135	1	the	the	DET
gs-3799	135	2	paradigm	paradigm	NOUN
gs-3799	135	3	shift	shift	NOUN
gs-3799	135	4	to	to	ADP
gs-3799	135	5	automation	automation	NOUN
gs-3799	135	6	:	:	PUNCT
gs-3799	135	7	closed	closed	ADJ
gs-3799	135	8	-	-	PUNCT
gs-3799	135	9	loop	loop	NOUN
gs-3799	135	10	cpb	cpb	NOUN
gs-3799	135	11	systems	system	NOUN
gs-3799	135	12	emerge	emerge	VERB
gs-3799	135	13	not	not	PART
gs-3799	135	14	merely	merely	ADV
gs-3799	135	15	as	as	ADP
gs-3799	135	16	incremental	incremental	ADJ
gs-3799	135	17	improvements	improvement	NOUN
gs-3799	135	18	but	but	CCONJ
gs-3799	135	19	as	as	ADP
gs-3799	135	20	a	a	DET
gs-3799	135	21	fundamental	fundamental	ADJ
gs-3799	135	22	reimagining	reimagining	NOUN
gs-3799	135	23	of	of	ADP
gs-3799	135	24	extracorporeal	extracorporeal	NOUN
gs-3799	135	25	circulation	circulation	NOUN
gs-3799	135	26	.	.	PUNCT
gs-3799	136	1	these	these	DET
gs-3799	136	2	systems	system	NOUN
gs-3799	136	3	integrate	integrate	VERB
gs-3799	136	4	sophisticated	sophisticated	ADJ
gs-3799	136	5	real	real	ADJ
gs-3799	136	6	-	-	PUNCT
gs-3799	136	7	time	time	NOUN
gs-3799	136	8	multimodal	multimodal	NOUN
gs-3799	136	9	monitoring	monitoring	NOUN
gs-3799	136	10	with	with	ADP
gs-3799	136	11	algorithm	algorithm	NOUN
gs-3799	136	12	-	-	PUNCT
gs-3799	136	13	driven	drive	VERB
gs-3799	136	14	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	136	15	delivery	delivery	NOUN
gs-3799	136	16	within	within	ADP
gs-3799	136	17	a	a	DET
gs-3799	136	18	unified	unified	ADJ
gs-3799	136	19	architecture	architecture	NOUN
gs-3799	136	20	,	,	PUNCT
gs-3799	136	21	creating	create	VERB
gs-3799	136	22	an	an	DET
gs-3799	136	23	autonomous	autonomous	ADJ
gs-3799	136	24	physiological	physiological	ADJ
gs-3799	136	25	management	management	NOUN
gs-3799	136	26	platform	platform	NOUN
gs-3799	136	27	.	.	PUNCT
gs-3799	137	1	by	by	ADP
gs-3799	137	2	transcending	transcend	VERB
gs-3799	137	3	human	human	ADJ
gs-3799	137	4	reaction	reaction	NOUN
gs-3799	137	5	times	time	NOUN
gs-3799	137	6	and	and	CCONJ
gs-3799	137	7	cognitive	cognitive	ADJ
gs-3799	137	8	limitations	limitation	NOUN
gs-3799	137	9	,	,	PUNCT
gs-3799	137	10	these	these	DET
gs-3799	137	11	systems	system	NOUN
gs-3799	137	12	promise	promise	VERB
gs-3799	137	13	unprecedented	unprecedented	ADJ
gs-3799	137	14	hemodynamic	hemodynamic	ADJ
gs-3799	137	15	stability	stability	NOUN
gs-3799	137	16	,	,	PUNCT
gs-3799	137	17	optimized	optimize	VERB
gs-3799	137	18	organ	organ	NOUN
gs-3799	137	19	protection	protection	NOUN
gs-3799	137	20	,	,	PUNCT
gs-3799	137	21	and	and	CCONJ
gs-3799	137	22	personalized	personalize	VERB
gs-3799	137	23	intraoperative	intraoperative	ADJ
gs-3799	137	24	care	care	NOUN
gs-3799	137	25	.	.	PUNCT
gs-3799	138	1	the	the	DET
gs-3799	138	2	core	core	NOUN
gs-3799	138	3	innovation	innovation	NOUN
gs-3799	138	4	lies	lie	VERB
gs-3799	138	5	in	in	ADP
gs-3799	138	6	the	the	DET
gs-3799	138	7	creation	creation	NOUN
gs-3799	138	8	of	of	ADP
gs-3799	138	9	a	a	DET
gs-3799	138	10	dynamic	dynamic	ADJ
gs-3799	138	11	feedback	feedback	NOUN
gs-3799	138	12	loop	loop	NOUN
gs-3799	138	13	where	where	SCONJ
gs-3799	138	14	continuous	continuous	ADJ
gs-3799	138	15	physiological	physiological	ADJ
gs-3799	138	16	data	datum	NOUN
gs-3799	138	17	streams	stream	NOUN
gs-3799	138	18	inform	inform	VERB
gs-3799	138	19	instantaneous	instantaneous	ADJ
gs-3799	138	20	therapeutic	therapeutic	ADJ
gs-3799	138	21	adjustments	adjustment	NOUN
gs-3799	138	22	,	,	PUNCT
gs-3799	138	23	effectively	effectively	ADV
gs-3799	138	24	transforming	transform	VERB
gs-3799	138	25	the	the	DET
gs-3799	138	26	static	static	ADJ
gs-3799	138	27	bypass	bypass	NOUN
gs-3799	138	28	circuit	circuit	NOUN
gs-3799	138	29	into	into	ADP
gs-3799	138	30	a	a	DET
gs-3799	138	31	responsive	responsive	ADJ
gs-3799	138	32	"	"	PUNCT
gs-3799	138	33	smart	smart	ADJ
gs-3799	138	34	"	"	PUNCT
gs-3799	138	35	system	system	NOUN
gs-3799	138	36	capable	capable	ADJ
gs-3799	138	37	of	of	ADP
gs-3799	138	38	anticipating	anticipate	VERB
gs-3799	138	39	and	and	CCONJ
gs-3799	138	40	mitigating	mitigate	VERB
gs-3799	138	41	perturbations	perturbation	NOUN
gs-3799	138	42	before	before	SCONJ
gs-3799	138	43	they	they	PRON
gs-3799	138	44	evolve	evolve	VERB
gs-3799	138	45	into	into	ADP
gs-3799	138	46	clinical	clinical	ADJ
gs-3799	138	47	instability	instability	NOUN
gs-3799	138	48	.	.	PUNCT
gs-3799	139	1	technological	technological	ADJ
gs-3799	139	2	foundations	foundation	NOUN
gs-3799	139	3	:	:	PUNCT
gs-3799	139	4	the	the	DET
gs-3799	139	5	revolutionary	revolutionary	ADJ
gs-3799	139	6	potential	potential	NOUN
gs-3799	139	7	of	of	ADP
gs-3799	139	8	closed	closed	ADJ
gs-3799	139	9	-	-	PUNCT
gs-3799	139	10	loop	loop	NOUN
gs-3799	139	11	systems	system	NOUN
gs-3799	139	12	rests	rest	VERB
gs-3799	139	13	upon	upon	SCONJ
gs-3799	139	14	three	three	NUM
gs-3799	139	15	interdependent	interdependent	ADJ
gs-3799	139	16	technological	technological	ADJ
gs-3799	139	17	pillars	pillar	NOUN
gs-3799	139	18	.	.	PUNCT
gs-3799	140	1	first	first	ADV
gs-3799	140	2	,	,	PUNCT
gs-3799	140	3	advanced	advanced	ADJ
gs-3799	140	4	biosensing	biosensing	NOUN
gs-3799	140	5	platforms	platform	NOUN
gs-3799	140	6	provide	provide	VERB
gs-3799	140	7	continuous	continuous	ADJ
gs-3799	140	8	hemodynamic	hemodynamic	ADJ
gs-3799	140	9	,	,	PUNCT
gs-3799	140	10	metabolic	metabolic	NOUN
gs-3799	140	11	,	,	PUNCT
gs-3799	140	12	and	and	CCONJ
gs-3799	140	13	hematological	hematological	ADJ
gs-3799	140	14	profiling	profiling	NOUN
gs-3799	140	15	through	through	ADP
gs-3799	140	16	non	non	ADJ
gs-3799	140	17	-	-	ADJ
gs-3799	140	18	invasive	invasive	ADJ
gs-3799	140	19	optical	optical	ADJ
gs-3799	140	20	sensors	sensor	NOUN
gs-3799	140	21	,	,	PUNCT
gs-3799	140	22	georgian	georgian	NOUN
gs-3799	140	23	scientists/	scientists/	NUM
gs-3799	140	24	.	.	PUNCT
gs-3799	141	1	7	7	NUM
gs-3799	141	2	n	n	PRON
gs-3799	141	3	2	2	NUM
gs-3799	141	4	,	,	PUNCT
gs-3799	141	5	2025	2025	NUM
gs-3799	141	6	388	388	NUM
gs-3799	141	7	microfluidic	microfluidic	ADJ
gs-3799	141	8	chips	chip	NOUN
gs-3799	141	9	,	,	PUNCT
gs-3799	141	10	and	and	CCONJ
gs-3799	141	11	indwelling	indwell	VERB
gs-3799	141	12	spectrophotometric	spectrophotometric	ADJ
gs-3799	141	13	catheters	catheter	NOUN
gs-3799	141	14	that	that	PRON
gs-3799	141	15	monitor	monitor	VERB
gs-3799	141	16	parameters	parameter	NOUN
gs-3799	141	17	from	from	ADP
gs-3799	141	18	oxygen	oxygen	NOUN
gs-3799	141	19	saturation	saturation	NOUN
gs-3799	141	20	to	to	ADP
gs-3799	141	21	lactate	lactate	NOUN
gs-3799	141	22	levels	level	NOUN
gs-3799	141	23	and	and	CCONJ
gs-3799	141	24	coagulation	coagulation	NOUN
gs-3799	141	25	status	status	NOUN
gs-3799	141	26	at	at	ADP
gs-3799	141	27	sub	sub	ADJ
gs-3799	141	28	-	-	ADJ
gs-3799	141	29	minute	minute	ADJ
gs-3799	141	30	intervals	interval	NOUN
gs-3799	141	31	.	.	PUNCT
gs-3799	142	1	second	second	ADJ
gs-3799	142	2	,	,	PUNCT
gs-3799	142	3	miniaturized	miniaturized	ADJ
gs-3799	142	4	circuit	circuit	NOUN
gs-3799	142	5	architecture	architecture	NOUN
gs-3799	142	6	drastically	drastically	ADV
gs-3799	142	7	reduces	reduce	VERB
gs-3799	142	8	foreign	foreign	ADJ
gs-3799	142	9	surface	surface	NOUN
gs-3799	142	10	exposure	exposure	NOUN
gs-3799	142	11	through	through	ADP
gs-3799	142	12	shortened	shorten	VERB
gs-3799	142	13	heparin	heparin	NOUN
gs-3799	142	14	-	-	PUNCT
gs-3799	142	15	coated	coat	VERB
gs-3799	142	16	tubing	tubing	NOUN
gs-3799	142	17	,	,	PUNCT
gs-3799	142	18	centrifugal	centrifugal	ADJ
gs-3799	142	19	pumps	pump	NOUN
gs-3799	142	20	,	,	PUNCT
gs-3799	142	21	and	and	CCONJ
gs-3799	142	22	membrane	membrane	NOUN
gs-3799	142	23	oxygenators	oxygenator	NOUN
gs-3799	142	24	integrated	integrate	VERB
gs-3799	142	25	with	with	ADP
gs-3799	142	26	heat	heat	NOUN
gs-3799	142	27	exchangers	exchanger	NOUN
gs-3799	142	28	,	,	PUNCT
gs-3799	142	29	achieving	achieve	VERB
gs-3799	142	30	priming	priming	NOUN
gs-3799	142	31	volumes	volume	NOUN
gs-3799	142	32	as	as	ADV
gs-3799	142	33	low	low	ADJ
gs-3799	142	34	as	as	ADP
gs-3799	142	35	300	300	NUM
gs-3799	142	36	-	-	NUM
gs-3799	142	37	500ml	500ml	NOUN
gs-3799	142	38	compared	compare	VERB
gs-3799	142	39	to	to	ADP
gs-3799	142	40	conventional	conventional	ADJ
gs-3799	142	41	systems	system	NOUN
gs-3799	142	42	.	.	PUNCT
gs-3799	143	1	third	third	ADJ
gs-3799	143	2	,	,	PUNCT
gs-3799	143	3	intelligent	intelligent	ADJ
gs-3799	143	4	drug	drug	NOUN
gs-3799	143	5	delivery	delivery	NOUN
gs-3799	143	6	systems	system	NOUN
gs-3799	143	7	employ	employ	VERB
gs-3799	143	8	servo	servo	NOUN
gs-3799	143	9	-	-	PUNCT
gs-3799	143	10	controlled	control	VERB
gs-3799	143	11	syringe	syringe	NOUN
gs-3799	143	12	pumps	pump	NOUN
gs-3799	143	13	interfaced	interface	VERB
gs-3799	143	14	with	with	ADP
gs-3799	143	15	pharmacokinetic	pharmacokinetic	ADJ
gs-3799	143	16	-	-	PUNCT
gs-3799	143	17	pharmacodynamic	pharmacodynamic	ADJ
gs-3799	143	18	models	model	NOUN
gs-3799	143	19	that	that	PRON
gs-3799	143	20	precisely	precisely	ADV
gs-3799	143	21	titrate	titrate	ADJ
gs-3799	143	22	anticoagulants	anticoagulant	NOUN
gs-3799	143	23	,	,	PUNCT
gs-3799	143	24	vasoactive	vasoactive	ADJ
gs-3799	143	25	agents	agent	NOUN
gs-3799	143	26	,	,	PUNCT
gs-3799	143	27	anti	anti	NOUN
gs-3799	143	28	-	-	NOUN
gs-3799	143	29	inflammatories	inflammatorie	NOUN
gs-3799	143	30	,	,	PUNCT
gs-3799	143	31	and	and	CCONJ
gs-3799	143	32	cardioplegia	cardioplegia	PROPN
gs-3799	143	33	solutions	solution	NOUN
gs-3799	143	34	based	base	VERB
gs-3799	143	35	on	on	ADP
gs-3799	143	36	real	real	ADJ
gs-3799	143	37	-	-	PUNCT
gs-3799	143	38	time	time	NOUN
gs-3799	143	39	physiological	physiological	ADJ
gs-3799	143	40	demands	demand	NOUN
gs-3799	143	41	.	.	PUNCT
gs-3799	144	1	the	the	DET
gs-3799	144	2	future	future	NOUN
gs-3799	144	3	of	of	ADP
gs-3799	144	4	cpb	cpb	PROPN
gs-3799	144	5	lies	lie	VERB
gs-3799	144	6	in	in	ADP
gs-3799	144	7	the	the	DET
gs-3799	144	8	continued	continue	VERB
gs-3799	144	9	evolution	evolution	NOUN
gs-3799	144	10	of	of	ADP
gs-3799	144	11	automation	automation	NOUN
gs-3799	144	12	,	,	PUNCT
gs-3799	144	13	integration	integration	NOUN
gs-3799	144	14	,	,	PUNCT
gs-3799	144	15	and	and	CCONJ
gs-3799	144	16	personalization	personalization	NOUN
gs-3799	144	17	.	.	PUNCT
gs-3799	145	1	emerging	emerge	VERB
gs-3799	145	2	research	research	NOUN
gs-3799	145	3	focuses	focus	VERB
gs-3799	145	4	on	on	ADP
gs-3799	145	5	hybrid	hybrid	ADJ
gs-3799	145	6	systems	system	NOUN
gs-3799	145	7	that	that	PRON
gs-3799	145	8	combine	combine	VERB
gs-3799	145	9	closed	close	VERB
gs-3799	145	10	-	-	PUNCT
gs-3799	145	11	loop	loop	NOUN
gs-3799	145	12	control	control	NOUN
gs-3799	145	13	with	with	ADP
gs-3799	145	14	operator	operator	NOUN
gs-3799	145	15	input	input	NOUN
gs-3799	145	16	,	,	PUNCT
gs-3799	145	17	advanced	advanced	ADJ
gs-3799	145	18	simulation	simulation	NOUN
gs-3799	145	19	platforms	platform	NOUN
gs-3799	145	20	for	for	ADP
gs-3799	145	21	training	training	NOUN
gs-3799	145	22	,	,	PUNCT
gs-3799	145	23	and	and	CCONJ
gs-3799	145	24	machine	machine	NOUN
gs-3799	145	25	-	-	PUNCT
gs-3799	145	26	learning	learn	VERB
gs-3799	145	27	models	model	NOUN
gs-3799	145	28	that	that	PRON
gs-3799	145	29	predict	predict	VERB
gs-3799	145	30	intraoperative	intraoperative	ADJ
gs-3799	145	31	events	event	NOUN
gs-3799	145	32	before	before	SCONJ
gs-3799	145	33	they	they	PRON
gs-3799	145	34	occur	occur	VERB
gs-3799	145	35	.	.	PUNCT
gs-3799	146	1	additionally	additionally	ADV
gs-3799	146	2	,	,	PUNCT
gs-3799	146	3	the	the	DET
gs-3799	146	4	increasing	increase	VERB
gs-3799	146	5	availability	availability	NOUN
gs-3799	146	6	of	of	ADP
gs-3799	146	7	big	big	ADJ
gs-3799	146	8	data	datum	NOUN
gs-3799	146	9	from	from	ADP
gs-3799	146	10	cpb	cpb	NOUN
gs-3799	146	11	procedures	procedure	NOUN
gs-3799	146	12	will	will	AUX
gs-3799	146	13	enable	enable	VERB
gs-3799	146	14	benchmarking	benchmarke	VERB
gs-3799	146	15	,	,	PUNCT
gs-3799	146	16	quality	quality	NOUN
gs-3799	146	17	improvement	improvement	NOUN
gs-3799	146	18	,	,	PUNCT
gs-3799	146	19	and	and	CCONJ
gs-3799	146	20	population	population	NOUN
gs-3799	146	21	-	-	PUNCT
gs-3799	146	22	level	level	NOUN
gs-3799	146	23	insights	insight	NOUN
gs-3799	146	24	into	into	ADP
gs-3799	146	25	best	good	ADJ
gs-3799	146	26	practices	practice	NOUN
gs-3799	146	27	.	.	PUNCT
gs-3799	147	1	these	these	DET
gs-3799	147	2	developments	development	NOUN
gs-3799	147	3	will	will	AUX
gs-3799	147	4	likely	likely	ADV
gs-3799	147	5	reshape	reshape	VERB
gs-3799	147	6	the	the	DET
gs-3799	147	7	landscape	landscape	NOUN
gs-3799	147	8	of	of	ADP
gs-3799	147	9	cardiac	cardiac	ADJ
gs-3799	147	10	surgery	surgery	NOUN
gs-3799	147	11	,	,	PUNCT
gs-3799	147	12	offering	offer	VERB
gs-3799	147	13	safer	safe	ADJ
gs-3799	147	14	,	,	PUNCT
gs-3799	147	15	more	more	ADV
gs-3799	147	16	efficient	efficient	ADJ
gs-3799	147	17	,	,	PUNCT
gs-3799	147	18	and	and	CCONJ
gs-3799	147	19	patient	patient	NOUN
gs-3799	147	20	-	-	PUNCT
gs-3799	147	21	centered	center	VERB
gs-3799	147	22	care	care	NOUN
gs-3799	147	23	.	.	PUNCT
gs-3799	148	1	background	background	NOUN
gs-3799	148	2	being	be	AUX
gs-3799	148	3	the	the	DET
gs-3799	148	4	pinnacle	pinnacle	NOUN
gs-3799	148	5	of	of	ADP
gs-3799	148	6	modern	modern	ADJ
gs-3799	148	7	cardiac	cardiac	ADJ
gs-3799	148	8	surgery	surgery	NOUN
gs-3799	148	9	,	,	PUNCT
gs-3799	148	10	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	148	11	bypass	bypass	NOUN
gs-3799	148	12	(	(	PUNCT
gs-3799	148	13	cpb	cpb	NOUN
gs-3799	148	14	)	)	PUNCT
gs-3799	148	15	has	have	AUX
gs-3799	148	16	become	become	VERB
gs-3799	148	17	a	a	DET
gs-3799	148	18	vital	vital	ADJ
gs-3799	148	19	component	component	NOUN
gs-3799	148	20	in	in	ADP
gs-3799	148	21	repairing	repair	VERB
gs-3799	148	22	congenital	congenital	ADJ
gs-3799	148	23	heart	heart	NOUN
gs-3799	148	24	defects	defect	NOUN
gs-3799	148	25	,	,	PUNCT
gs-3799	148	26	especially	especially	ADV
gs-3799	148	27	in	in	ADP
gs-3799	148	28	neonates	neonate	NOUN
gs-3799	148	29	and	and	CCONJ
gs-3799	148	30	infants	infant	NOUN
gs-3799	148	31	.	.	PUNCT
gs-3799	149	1	this	this	DET
gs-3799	149	2	extracorporeal	extracorporeal	NOUN
gs-3799	149	3	device	device	NOUN
gs-3799	149	4	temporarily	temporarily	ADV
gs-3799	149	5	substitutes	substitute	VERB
gs-3799	149	6	heart	heart	NOUN
gs-3799	149	7	and	and	CCONJ
gs-3799	149	8	lung	lung	NOUN
gs-3799	149	9	functions	function	NOUN
gs-3799	149	10	during	during	ADP
gs-3799	149	11	such	such	ADJ
gs-3799	149	12	intricate	intricate	ADJ
gs-3799	149	13	procedures	procedure	NOUN
gs-3799	149	14	.	.	PUNCT
gs-3799	150	1	despite	despite	SCONJ
gs-3799	150	2	its	its	PRON
gs-3799	150	3	effectiveness	effectiveness	NOUN
gs-3799	150	4	,	,	PUNCT
gs-3799	150	5	traditional	traditional	ADJ
gs-3799	150	6	methods	method	NOUN
gs-3799	150	7	of	of	ADP
gs-3799	150	8	cpb	cpb	PROPN
gs-3799	150	9	represent	represent	VERB
gs-3799	150	10	the	the	DET
gs-3799	150	11	analogy	analogy	NOUN
gs-3799	150	12	of	of	ADP
gs-3799	150	13	a	a	DET
gs-3799	150	14	toaster	toaster	NOUN
gs-3799	150	15	that	that	PRON
gs-3799	150	16	toasts	toast	VERB
gs-3799	150	17	for	for	ADP
gs-3799	150	18	a	a	DET
gs-3799	150	19	fixed	fix	VERB
gs-3799	150	20	time	time	NOUN
gs-3799	150	21	,	,	PUNCT
gs-3799	150	22	regardless	regardless	ADV
gs-3799	150	23	of	of	ADP
gs-3799	150	24	how	how	SCONJ
gs-3799	150	25	brown	brown	ADJ
gs-3799	150	26	the	the	DET
gs-3799	150	27	bread	bread	NOUN
gs-3799	150	28	gets	get	VERB
gs-3799	150	29	.	.	PUNCT
gs-3799	151	1	operation	operation	NOUN
gs-3799	151	2	of	of	ADP
gs-3799	151	3	the	the	DET
gs-3799	151	4	open	open	ADJ
gs-3799	151	5	-	-	PUNCT
gs-3799	151	6	loop	loop	NOUN
gs-3799	151	7	cpb	cpb	NOUN
gs-3799	151	8	system	system	NOUN
gs-3799	151	9	greatly	greatly	ADV
gs-3799	151	10	depends	depend	VERB
gs-3799	151	11	on	on	ADP
gs-3799	151	12	the	the	DET
gs-3799	151	13	knowledge	knowledge	NOUN
gs-3799	151	14	and	and	CCONJ
gs-3799	151	15	competence	competence	NOUN
gs-3799	151	16	of	of	ADP
gs-3799	151	17	percussionists	percussionist	NOUN
gs-3799	151	18	and	and	CCONJ
gs-3799	151	19	anesthesiologists	anesthesiologist	NOUN
gs-3799	151	20	,	,	PUNCT
gs-3799	151	21	who	who	PRON
gs-3799	151	22	manually	manually	ADV
gs-3799	151	23	have	have	VERB
gs-3799	151	24	to	to	PART
gs-3799	151	25	set	set	VERB
gs-3799	151	26	and	and	CCONJ
gs-3799	151	27	maintain	maintain	VERB
gs-3799	151	28	flow	flow	NOUN
gs-3799	151	29	rates	rate	NOUN
gs-3799	151	30	,	,	PUNCT
gs-3799	151	31	blood	blood	NOUN
gs-3799	151	32	pressures	pressure	NOUN
gs-3799	151	33	,	,	PUNCT
gs-3799	151	34	and	and	CCONJ
gs-3799	151	35	oxygenation	oxygenation	NOUN
gs-3799	151	36	levels	level	NOUN
gs-3799	151	37	based	base	VERB
gs-3799	151	38	on	on	ADP
gs-3799	151	39	periodic	periodic	ADJ
gs-3799	151	40	readings	reading	NOUN
gs-3799	151	41	.	.	PUNCT
gs-3799	152	1	this	this	PRON
gs-3799	152	2	increases	increase	VERB
gs-3799	152	3	the	the	DET
gs-3799	152	4	likelihood	likelihood	NOUN
gs-3799	152	5	of	of	ADP
gs-3799	152	6	developing	develop	VERB
gs-3799	152	7	hemodynamic	hemodynamic	ADJ
gs-3799	152	8	instability	instability	NOUN
gs-3799	152	9	,	,	PUNCT
gs-3799	152	10	organ	organ	NOUN
gs-3799	152	11	hypo	hypo	ADJ
gs-3799	152	12	perfusion	perfusion	NOUN
gs-3799	152	13	,	,	PUNCT
gs-3799	152	14	inflammatory	inflammatory	ADJ
gs-3799	152	15	response	response	NOUN
gs-3799	152	16	,	,	PUNCT
gs-3799	152	17	and	and	CCONJ
gs-3799	152	18	neurodevelopmental	neurodevelopmental	ADJ
gs-3799	152	19	complications	complication	NOUN
gs-3799	152	20	in	in	ADP
gs-3799	152	21	pediatric	pediatric	ADJ
gs-3799	152	22	patients	patient	NOUN
gs-3799	152	23	.	.	PUNCT
gs-3799	153	1	as	as	ADP
gs-3799	153	2	a	a	DET
gs-3799	153	3	response	response	NOUN
gs-3799	153	4	to	to	ADP
gs-3799	153	5	these	these	DET
gs-3799	153	6	shortcomings	shortcoming	NOUN
gs-3799	153	7	,	,	PUNCT
gs-3799	153	8	research	research	NOUN
gs-3799	153	9	into	into	ADP
gs-3799	153	10	closed	closed	ADJ
gs-3799	153	11	-	-	PUNCT
gs-3799	153	12	loop	loop	NOUN
gs-3799	153	13	cpb	cpb	NOUN
gs-3799	153	14	systems	system	NOUN
gs-3799	153	15	has	have	AUX
gs-3799	153	16	been	be	AUX
gs-3799	153	17	of	of	ADP
gs-3799	153	18	interest	interest	NOUN
gs-3799	153	19	because	because	SCONJ
gs-3799	153	20	it	it	PRON
gs-3799	153	21	uses	use	VERB
gs-3799	153	22	continuous	continuous	ADJ
gs-3799	153	23	and	and	CCONJ
gs-3799	153	24	immediate	immediate	ADJ
gs-3799	153	25	measurement	measurement	NOUN
gs-3799	153	26	and	and	CCONJ
gs-3799	153	27	display	display	NOUN
gs-3799	153	28	of	of	ADP
gs-3799	153	29	a	a	DET
gs-3799	153	30	patient	patient	NOUN
gs-3799	153	31	’s	’s	PART
gs-3799	153	32	vital	vital	ADJ
gs-3799	153	33	physiological	physiological	ADJ
gs-3799	153	34	parameters	parameter	NOUN
gs-3799	153	35	to	to	PART
gs-3799	153	36	automatically	automatically	ADV
gs-3799	153	37	adjust	adjust	VERB
gs-3799	153	38	the	the	DET
gs-3799	153	39	performance	performance	NOUN
gs-3799	153	40	and	and	CCONJ
gs-3799	153	41	keep	keep	VERB
gs-3799	153	42	the	the	DET
gs-3799	153	43	output	output	NOUN
gs-3799	153	44	within	within	ADP
gs-3799	153	45	the	the	DET
gs-3799	153	46	required	require	VERB
gs-3799	153	47	ranges	range	NOUN
gs-3799	153	48	.	.	PUNCT
gs-3799	154	1	control	control	NOUN
gs-3799	154	2	engineering	engineering	PROPN
gs-3799	154	3	,	,	PUNCT
gs-3799	154	4	which	which	PRON
gs-3799	154	5	is	be	AUX
gs-3799	154	6	designed	design	VERB
gs-3799	154	7	to	to	PART
gs-3799	154	8	use	use	VERB
gs-3799	154	9	a	a	DET
gs-3799	154	10	continuous	continuous	ADJ
gs-3799	154	11	feedback	feedback	NOUN
gs-3799	154	12	loop	loop	NOUN
gs-3799	154	13	that	that	PRON
gs-3799	154	14	measures	measure	VERB
gs-3799	154	15	the	the	DET
gs-3799	154	16	output	output	NOUN
gs-3799	154	17	and	and	CCONJ
gs-3799	154	18	regulates	regulate	VERB
gs-3799	154	19	the	the	DET
gs-3799	154	20	input	input	NOUN
gs-3799	154	21	appropriately	appropriately	ADV
gs-3799	154	22	,	,	PUNCT
gs-3799	154	23	is	be	AUX
gs-3799	154	24	where	where	SCONJ
gs-3799	154	25	the	the	DET
gs-3799	154	26	concept	concept	NOUN
gs-3799	154	27	of	of	ADP
gs-3799	154	28	closed	closed	ADJ
gs-3799	154	29	-	-	PUNCT
gs-3799	154	30	loop	loop	NOUN
gs-3799	154	31	cpb	cpb	PROPN
gs-3799	154	32	systems	system	NOUN
gs-3799	154	33	was	be	AUX
gs-3799	154	34	derived	derive	VERB
gs-3799	154	35	.	.	PUNCT
gs-3799	155	1	so	so	ADV
gs-3799	155	2	how	how	SCONJ
gs-3799	155	3	do	do	AUX
gs-3799	155	4	we	we	PRON
gs-3799	155	5	apply	apply	VERB
gs-3799	155	6	this	this	DET
gs-3799	155	7	mechanism	mechanism	NOUN
gs-3799	155	8	to	to	ADP
gs-3799	155	9	cpb	cpb	NOUN
gs-3799	155	10	systems	system	NOUN
gs-3799	155	11	?	?	PUNCT
gs-3799	156	1	instead	instead	ADV
gs-3799	156	2	of	of	ADP
gs-3799	156	3	the	the	DET
gs-3799	156	4	clinicians	clinician	NOUN
gs-3799	156	5	constantly	constantly	ADV
gs-3799	156	6	reviewing	review	VERB
gs-3799	156	7	and	and	CCONJ
gs-3799	156	8	manually	manually	ADV
gs-3799	156	9	adjusting	adjust	VERB
gs-3799	156	10	parameters	parameter	NOUN
gs-3799	156	11	such	such	ADJ
gs-3799	156	12	as	as	ADP
gs-3799	156	13	mean	mean	ADJ
gs-3799	156	14	arterial	arterial	ADJ
gs-3799	156	15	pressure	pressure	NOUN
gs-3799	156	16	(	(	PUNCT
gs-3799	156	17	map	map	NOUN
gs-3799	156	18	)	)	PUNCT
gs-3799	156	19	,	,	PUNCT
gs-3799	156	20	oxygen	oxygen	NOUN
gs-3799	156	21	saturation	saturation	NOUN
gs-3799	156	22	,	,	PUNCT
gs-3799	156	23	cerebral	cerebral	ADJ
gs-3799	156	24	perfusion	perfusion	NOUN
gs-3799	156	25	,	,	PUNCT
gs-3799	156	26	lactate	lactate	NOUN
gs-3799	156	27	levels	level	NOUN
gs-3799	156	28	,	,	PUNCT
gs-3799	156	29	and	and	CCONJ
gs-3799	156	30	venous	venous	ADJ
gs-3799	156	31	oxygen	oxygen	NOUN
gs-3799	156	32	content	content	NOUN
gs-3799	156	33	,	,	PUNCT
gs-3799	156	34	real	real	ADJ
gs-3799	156	35	-	-	PUNCT
gs-3799	156	36	time	time	NOUN
gs-3799	156	37	sensors	sensor	NOUN
gs-3799	156	38	may	may	AUX
gs-3799	156	39	monitor	monitor	VERB
gs-3799	156	40	these	these	DET
gs-3799	156	41	values	value	NOUN
gs-3799	156	42	,	,	PUNCT
gs-3799	156	43	which	which	PRON
gs-3799	156	44	then	then	ADV
gs-3799	156	45	get	get	AUX
gs-3799	156	46	interpreted	interpret	VERB
gs-3799	156	47	by	by	ADP
gs-3799	156	48	software	software	NOUN
gs-3799	156	49	algorithms	algorithm	NOUN
gs-3799	156	50	—	—	PUNCT
gs-3799	156	51	enhanced	enhance	VERB
gs-3799	156	52	with	with	ADP
gs-3799	156	53	artificial	artificial	ADJ
gs-3799	156	54	intelligence	intelligence	NOUN
gs-3799	156	55	or	or	CCONJ
gs-3799	156	56	machine	machine	NOUN
gs-3799	156	57	learning	learning	NOUN
gs-3799	156	58	—	—	PUNCT
gs-3799	156	59	and	and	CCONJ
gs-3799	156	60	finally	finally	ADV
gs-3799	156	61	calibrates	calibrate	VERB
gs-3799	156	62	the	the	DET
gs-3799	156	63	pump	pump	NOUN
gs-3799	156	64	speed	speed	NOUN
gs-3799	156	65	,	,	PUNCT
gs-3799	156	66	flow	flow	NOUN
gs-3799	156	67	rate	rate	NOUN
gs-3799	156	68	and	and	CCONJ
gs-3799	156	69	oxygenator	oxygenator	NOUN
gs-3799	156	70	function	function	NOUN
gs-3799	156	71	.	.	PUNCT
gs-3799	157	1	the	the	DET
gs-3799	157	2	closed	close	VERB
gs-3799	157	3	-	-	PUNCT
gs-3799	157	4	loop	loop	NOUN
gs-3799	157	5	mechanism	mechanism	NOUN
gs-3799	157	6	is	be	AUX
gs-3799	157	7	currently	currently	ADV
gs-3799	157	8	being	be	AUX
gs-3799	157	9	utilized	utilize	VERB
gs-3799	157	10	successfully	successfully	ADV
gs-3799	157	11	in	in	ADP
gs-3799	157	12	several	several	ADJ
gs-3799	157	13	pediatric	pediatric	ADJ
gs-3799	157	14	domains	domain	NOUN
gs-3799	157	15	inclusive	inclusive	ADJ
gs-3799	157	16	of	of	ADP
gs-3799	157	17	automated	automate	VERB
gs-3799	157	18	insulin	insulin	NOUN
gs-3799	157	19	delivery	delivery	NOUN
gs-3799	157	20	for	for	ADP
gs-3799	157	21	type	type	NOUN
gs-3799	157	22	1	1	NUM
gs-3799	157	23	diabetes	diabetes	NOUN
gs-3799	157	24	children	child	NOUN
gs-3799	157	25	,	,	PUNCT
gs-3799	157	26	automated	automate	VERB
gs-3799	157	27	mechanical	mechanical	ADJ
gs-3799	157	28	ventilation	ventilation	NOUN
gs-3799	157	29	,	,	PUNCT
gs-3799	157	30	georgian	georgian	NOUN
gs-3799	157	31	scientists/	scientists/	NUM
gs-3799	157	32	.	.	PUNCT
gs-3799	158	1	7	7	NUM
gs-3799	158	2	n	n	DET
gs-3799	158	3	2	2	NUM
gs-3799	158	4	,	,	PUNCT
gs-3799	158	5	2025	2025	NUM
gs-3799	158	6	389	389	NUM
gs-3799	158	7	target	target	NOUN
gs-3799	158	8	-	-	PUNCT
gs-3799	158	9	controlled	control	VERB
gs-3799	158	10	infusions	infusion	NOUN
gs-3799	158	11	systems	system	NOUN
gs-3799	158	12	and	and	CCONJ
gs-3799	158	13	thermoregulation	thermoregulation	NOUN
gs-3799	158	14	systems	system	NOUN
gs-3799	158	15	in	in	ADP
gs-3799	158	16	neonatal	neonatal	ADJ
gs-3799	158	17	intensive	intensive	ADJ
gs-3799	158	18	care	care	NOUN
gs-3799	158	19	units	unit	NOUN
gs-3799	158	20	.	.	PUNCT
gs-3799	159	1	thus	thus	ADV
gs-3799	159	2	,	,	PUNCT
gs-3799	159	3	the	the	DET
gs-3799	159	4	existence	existence	NOUN
gs-3799	159	5	of	of	ADP
gs-3799	159	6	this	this	DET
gs-3799	159	7	method	method	NOUN
gs-3799	159	8	has	have	AUX
gs-3799	159	9	proven	prove	VERB
gs-3799	159	10	to	to	PART
gs-3799	159	11	improve	improve	VERB
gs-3799	159	12	patient	patient	ADJ
gs-3799	159	13	outcomes	outcome	NOUN
gs-3799	159	14	by	by	ADP
gs-3799	159	15	decreasing	decrease	VERB
gs-3799	159	16	the	the	DET
gs-3799	159	17	lack	lack	NOUN
gs-3799	159	18	of	of	ADP
gs-3799	159	19	consistency	consistency	NOUN
gs-3799	159	20	,	,	PUNCT
gs-3799	159	21	enhancing	enhance	VERB
gs-3799	159	22	the	the	DET
gs-3799	159	23	rate	rate	NOUN
gs-3799	159	24	of	of	ADP
gs-3799	159	25	response	response	NOUN
gs-3799	159	26	and	and	CCONJ
gs-3799	159	27	ultimately	ultimately	ADV
gs-3799	159	28	rectifying	rectify	VERB
gs-3799	159	29	what	what	PRON
gs-3799	159	30	would	would	AUX
gs-3799	159	31	be	be	AUX
gs-3799	159	32	prone	prone	ADJ
gs-3799	159	33	to	to	ADP
gs-3799	159	34	human	human	ADJ
gs-3799	159	35	error	error	NOUN
gs-3799	159	36	.	.	PUNCT
gs-3799	160	1	recognizing	recognize	VERB
gs-3799	160	2	the	the	DET
gs-3799	160	3	accomplishment	accomplishment	NOUN
gs-3799	160	4	of	of	ADP
gs-3799	160	5	this	this	DET
gs-3799	160	6	approach	approach	NOUN
gs-3799	160	7	gives	give	VERB
gs-3799	160	8	us	we	PRON
gs-3799	160	9	the	the	DET
gs-3799	160	10	confidence	confidence	NOUN
gs-3799	160	11	to	to	PART
gs-3799	160	12	apply	apply	VERB
gs-3799	160	13	it	it	PRON
gs-3799	160	14	to	to	ADP
gs-3799	160	15	cpb	cpb	NOUN
gs-3799	160	16	which	which	PRON
gs-3799	160	17	would	would	AUX
gs-3799	160	18	aid	aid	VERB
gs-3799	160	19	in	in	ADP
gs-3799	160	20	improving	improve	VERB
gs-3799	160	21	perfusion	perfusion	NOUN
gs-3799	160	22	delivery	delivery	NOUN
gs-3799	160	23	during	during	ADP
gs-3799	160	24	surgery	surgery	NOUN
gs-3799	160	25	,	,	PUNCT
gs-3799	160	26	reduce	reduce	VERB
gs-3799	160	27	perioperative	perioperative	ADJ
gs-3799	160	28	complications	complication	NOUN
gs-3799	160	29	,	,	PUNCT
gs-3799	160	30	and	and	CCONJ
gs-3799	160	31	shorten	shorten	VERB
gs-3799	160	32	recovery	recovery	NOUN
gs-3799	160	33	times	time	NOUN
gs-3799	160	34	.	.	PUNCT
gs-3799	161	1	now	now	ADV
gs-3799	161	2	that	that	SCONJ
gs-3799	161	3	the	the	DET
gs-3799	161	4	idea	idea	NOUN
gs-3799	161	5	has	have	AUX
gs-3799	161	6	been	be	AUX
gs-3799	161	7	established	establish	VERB
gs-3799	161	8	,	,	PUNCT
gs-3799	161	9	ongoing	ongoing	ADJ
gs-3799	161	10	research	research	NOUN
gs-3799	161	11	is	be	AUX
gs-3799	161	12	being	be	AUX
gs-3799	161	13	conducted	conduct	VERB
gs-3799	161	14	to	to	PART
gs-3799	161	15	confirm	confirm	VERB
gs-3799	161	16	the	the	DET
gs-3799	161	17	accuracy	accuracy	NOUN
gs-3799	161	18	and	and	CCONJ
gs-3799	161	19	feasibility	feasibility	NOUN
gs-3799	161	20	of	of	ADP
gs-3799	161	21	this	this	DET
gs-3799	161	22	method	method	NOUN
gs-3799	161	23	.	.	PUNCT
gs-3799	162	1	many	many	ADJ
gs-3799	162	2	prototype	prototype	NOUN
gs-3799	162	3	systems	system	NOUN
gs-3799	162	4	have	have	AUX
gs-3799	162	5	been	be	AUX
gs-3799	162	6	used	use	VERB
gs-3799	162	7	in	in	ADP
gs-3799	162	8	control	control	NOUN
gs-3799	162	9	environments	environment	NOUN
gs-3799	162	10	to	to	PART
gs-3799	162	11	demonstrate	demonstrate	VERB
gs-3799	162	12	how	how	SCONJ
gs-3799	162	13	they	they	PRON
gs-3799	162	14	can	can	AUX
gs-3799	162	15	successfully	successfully	ADV
gs-3799	162	16	react	react	VERB
gs-3799	162	17	in	in	ADP
gs-3799	162	18	real	real	ADJ
gs-3799	162	19	-	-	PUNCT
gs-3799	162	20	time	time	NOUN
gs-3799	162	21	to	to	PART
gs-3799	162	22	changes	change	NOUN
gs-3799	162	23	such	such	ADJ
gs-3799	162	24	as	as	ADP
gs-3799	162	25	drops	drop	NOUN
gs-3799	162	26	in	in	ADP
gs-3799	162	27	blood	blood	NOUN
gs-3799	162	28	pressure	pressure	NOUN
gs-3799	162	29	,	,	PUNCT
gs-3799	162	30	sudden	sudden	ADJ
gs-3799	162	31	volume	volume	NOUN
gs-3799	162	32	shifts	shift	NOUN
gs-3799	162	33	,	,	PUNCT
gs-3799	162	34	and	and	CCONJ
gs-3799	162	35	cooling	cool	VERB
gs-3799	162	36	/	/	SYM
gs-3799	162	37	warming	warm	VERB
gs-3799	162	38	effects	effect	NOUN
gs-3799	162	39	during	during	ADP
gs-3799	162	40	bypass	bypass	NOUN
gs-3799	162	41	,	,	PUNCT
gs-3799	162	42	and	and	CCONJ
gs-3799	162	43	once	once	ADV
gs-3799	162	44	again	again	ADV
gs-3799	162	45	prove	prove	VERB
gs-3799	162	46	to	to	PART
gs-3799	162	47	be	be	AUX
gs-3799	162	48	more	more	ADV
gs-3799	162	49	hemodynamically	hemodynamically	ADV
gs-3799	162	50	stable	stable	ADJ
gs-3799	162	51	in	in	ADP
gs-3799	162	52	comparison	comparison	NOUN
gs-3799	162	53	to	to	ADP
gs-3799	162	54	open	open	VERB
gs-3799	162	55	loop	loop	NOUN
gs-3799	162	56	systems	system	NOUN
gs-3799	162	57	.	.	PUNCT
gs-3799	163	1	furthermore	furthermore	ADV
gs-3799	163	2	,	,	PUNCT
gs-3799	163	3	advances	advance	NOUN
gs-3799	163	4	in	in	ADP
gs-3799	163	5	non	non	ADJ
gs-3799	163	6	-	-	ADJ
gs-3799	163	7	invasive	invasive	ADJ
gs-3799	163	8	monitoring	monitoring	NOUN
gs-3799	163	9	technologies	technology	NOUN
gs-3799	163	10	—	—	PUNCT
gs-3799	163	11	like	like	INTJ
gs-3799	163	12	,	,	PUNCT
gs-3799	163	13	near	near	ADV
gs-3799	163	14	-	-	PUNCT
gs-3799	163	15	infrared	infrared	ADJ
gs-3799	163	16	spectroscopy	spectroscopy	NOUN
gs-3799	163	17	(	(	PUNCT
gs-3799	163	18	nirs	nirs	PROPN
gs-3799	163	19	)	)	PUNCT
gs-3799	163	20	,	,	PUNCT
gs-3799	163	21	continuous	continuous	ADJ
gs-3799	163	22	mixed	mixed	ADJ
gs-3799	163	23	venous	venous	ADJ
gs-3799	163	24	oxygen	oxygen	NOUN
gs-3799	163	25	saturation	saturation	NOUN
gs-3799	163	26	monitoring	monitoring	NOUN
gs-3799	163	27	,	,	PUNCT
gs-3799	163	28	and	and	CCONJ
gs-3799	163	29	microelectromechanical	microelectromechanical	ADJ
gs-3799	163	30	sensors	sensor	NOUN
gs-3799	163	31	—	—	PUNCT
gs-3799	163	32	have	have	AUX
gs-3799	163	33	enabled	enable	VERB
gs-3799	163	34	safer	safe	ADJ
gs-3799	163	35	and	and	CCONJ
gs-3799	163	36	more	more	ADV
gs-3799	163	37	precise	precise	ADJ
gs-3799	163	38	data	datum	NOUN
gs-3799	163	39	acquisition	acquisition	NOUN
gs-3799	163	40	in	in	ADP
gs-3799	163	41	real	real	ADJ
gs-3799	163	42	-	-	PUNCT
gs-3799	163	43	time	time	NOUN
gs-3799	163	44	.	.	PUNCT
gs-3799	164	1	as	as	ADV
gs-3799	164	2	great	great	ADJ
gs-3799	164	3	as	as	SCONJ
gs-3799	164	4	all	all	DET
gs-3799	164	5	this	this	PRON
gs-3799	164	6	may	may	AUX
gs-3799	164	7	sound	sound	VERB
gs-3799	164	8	,	,	PUNCT
gs-3799	164	9	we	we	PRON
gs-3799	164	10	do	do	AUX
gs-3799	164	11	have	have	VERB
gs-3799	164	12	to	to	PART
gs-3799	164	13	address	address	VERB
gs-3799	164	14	the	the	DET
gs-3799	164	15	obstacles	obstacle	NOUN
gs-3799	164	16	with	with	ADP
gs-3799	164	17	closed	closed	ADJ
gs-3799	164	18	-	-	PUNCT
gs-3799	164	19	loop	loop	NOUN
gs-3799	164	20	cpb	cpb	NOUN
gs-3799	164	21	as	as	ADV
gs-3799	164	22	well	well	ADV
gs-3799	164	23	.	.	PUNCT
gs-3799	165	1	these	these	PRON
gs-3799	165	2	may	may	AUX
gs-3799	165	3	range	range	VERB
gs-3799	165	4	from	from	ADP
gs-3799	165	5	the	the	DET
gs-3799	165	6	expenses	expense	NOUN
gs-3799	165	7	needed	need	VERB
gs-3799	165	8	to	to	PART
gs-3799	165	9	cover	cover	VERB
gs-3799	165	10	the	the	DET
gs-3799	165	11	development	development	NOUN
gs-3799	165	12	of	of	ADP
gs-3799	165	13	the	the	DET
gs-3799	165	14	equipment	equipment	NOUN
gs-3799	165	15	,	,	PUNCT
gs-3799	165	16	to	to	ADP
gs-3799	165	17	difficulty	difficulty	NOUN
gs-3799	165	18	in	in	ADP
gs-3799	165	19	incorporating	incorporate	VERB
gs-3799	165	20	this	this	DET
gs-3799	165	21	technique	technique	NOUN
gs-3799	165	22	into	into	ADP
gs-3799	165	23	a	a	DET
gs-3799	165	24	sequence	sequence	NOUN
gs-3799	165	25	of	of	ADP
gs-3799	165	26	coordinated	coordinated	ADJ
gs-3799	165	27	tasks	task	NOUN
gs-3799	165	28	usually	usually	ADV
gs-3799	165	29	done	do	VERB
gs-3799	165	30	during	during	ADP
gs-3799	165	31	surgery	surgery	NOUN
gs-3799	165	32	.	.	PUNCT
gs-3799	166	1	many	many	ADJ
gs-3799	166	2	ethical	ethical	ADJ
gs-3799	166	3	matters	matter	NOUN
gs-3799	166	4	also	also	ADV
gs-3799	166	5	need	need	VERB
gs-3799	166	6	to	to	PART
gs-3799	166	7	be	be	AUX
gs-3799	166	8	considered	consider	VERB
gs-3799	166	9	because	because	SCONJ
gs-3799	166	10	we	we	PRON
gs-3799	166	11	want	want	VERB
gs-3799	166	12	to	to	PART
gs-3799	166	13	ensure	ensure	VERB
gs-3799	166	14	patient	patient	ADJ
gs-3799	166	15	safety	safety	NOUN
gs-3799	166	16	and	and	CCONJ
gs-3799	166	17	informed	informed	ADJ
gs-3799	166	18	consent	consent	NOUN
gs-3799	166	19	will	will	AUX
gs-3799	166	20	be	be	AUX
gs-3799	166	21	required	require	VERB
gs-3799	166	22	as	as	SCONJ
gs-3799	166	23	our	our	PRON
gs-3799	166	24	whole	whole	ADJ
gs-3799	166	25	system	system	NOUN
gs-3799	166	26	is	be	AUX
gs-3799	166	27	based	base	VERB
gs-3799	166	28	on	on	ADP
gs-3799	166	29	trust	trust	NOUN
gs-3799	166	30	in	in	ADP
gs-3799	166	31	machines	machine	NOUN
gs-3799	166	32	vs	vs	ADP
gs-3799	166	33	human	human	ADJ
gs-3799	166	34	judgement	judgement	NOUN
gs-3799	166	35	.	.	PUNCT
gs-3799	167	1	in	in	ADP
gs-3799	167	2	spite	spite	NOUN
gs-3799	167	3	of	of	ADP
gs-3799	167	4	all	all	DET
gs-3799	167	5	this	this	PRON
gs-3799	167	6	,	,	PUNCT
gs-3799	167	7	we	we	PRON
gs-3799	167	8	should	should	AUX
gs-3799	167	9	keep	keep	VERB
gs-3799	167	10	in	in	ADP
gs-3799	167	11	mind	mind	NOUN
gs-3799	167	12	that	that	SCONJ
gs-3799	167	13	technology	technology	NOUN
gs-3799	167	14	and	and	CCONJ
gs-3799	167	15	algorithms	algorithm	NOUN
gs-3799	167	16	are	be	AUX
gs-3799	167	17	rapidly	rapidly	ADV
gs-3799	167	18	evolving	evolve	VERB
gs-3799	167	19	,	,	PUNCT
gs-3799	167	20	so	so	ADV
gs-3799	167	21	closed	closed	ADJ
gs-3799	167	22	-	-	PUNCT
gs-3799	167	23	looped	loop	VERB
gs-3799	167	24	systems	system	NOUN
gs-3799	167	25	have	have	VERB
gs-3799	167	26	a	a	DET
gs-3799	167	27	great	great	ADJ
gs-3799	167	28	possibility	possibility	NOUN
gs-3799	167	29	of	of	ADP
gs-3799	167	30	becoming	become	VERB
gs-3799	167	31	a	a	DET
gs-3799	167	32	core	core	ADJ
gs-3799	167	33	aspect	aspect	NOUN
gs-3799	167	34	of	of	ADP
gs-3799	167	35	futuristic	futuristic	ADJ
gs-3799	167	36	pediatric	pediatric	ADJ
gs-3799	167	37	cardiac	cardiac	ADJ
gs-3799	167	38	surgery	surgery	NOUN
gs-3799	167	39	.	.	PUNCT
gs-3799	168	1	the	the	DET
gs-3799	168	2	field	field	NOUN
gs-3799	168	3	of	of	ADP
gs-3799	168	4	extracorporeal	extracorporeal	NOUN
gs-3799	168	5	circulation	circulation	NOUN
gs-3799	168	6	,	,	PUNCT
gs-3799	168	7	and	and	CCONJ
gs-3799	168	8	specifically	specifically	ADV
gs-3799	168	9	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	168	10	bypass	bypass	NOUN
gs-3799	168	11	(	(	PUNCT
gs-3799	168	12	cpb	cpb	NOUN
gs-3799	168	13	)	)	PUNCT
gs-3799	168	14	,	,	PUNCT
gs-3799	168	15	has	have	AUX
gs-3799	168	16	witnessed	witness	VERB
gs-3799	168	17	transformative	transformative	ADJ
gs-3799	168	18	changes	change	NOUN
gs-3799	168	19	since	since	SCONJ
gs-3799	168	20	its	its	PRON
gs-3799	168	21	inception	inception	NOUN
gs-3799	168	22	.	.	PUNCT
gs-3799	169	1	cpb	cpb	NOUN
gs-3799	169	2	,	,	PUNCT
gs-3799	169	3	once	once	ADV
gs-3799	169	4	a	a	DET
gs-3799	169	5	static	static	ADJ
gs-3799	169	6	and	and	CCONJ
gs-3799	169	7	manually	manually	ADV
gs-3799	169	8	controlled	control	VERB
gs-3799	169	9	intervention	intervention	NOUN
gs-3799	169	10	,	,	PUNCT
gs-3799	169	11	has	have	AUX
gs-3799	169	12	gradually	gradually	ADV
gs-3799	169	13	evolved	evolve	VERB
gs-3799	169	14	into	into	ADP
gs-3799	169	15	a	a	DET
gs-3799	169	16	dynamic	dynamic	ADJ
gs-3799	169	17	process	process	NOUN
gs-3799	169	18	increasingly	increasingly	ADV
gs-3799	169	19	integrated	integrate	VERB
gs-3799	169	20	with	with	ADP
gs-3799	169	21	real	real	ADJ
gs-3799	169	22	-	-	PUNCT
gs-3799	169	23	time	time	NOUN
gs-3799	169	24	feedback	feedback	NOUN
gs-3799	169	25	mechanisms	mechanism	NOUN
gs-3799	169	26	and	and	CCONJ
gs-3799	169	27	therapeutic	therapeutic	ADJ
gs-3799	169	28	modulation	modulation	NOUN
gs-3799	169	29	.	.	PUNCT
gs-3799	170	1	the	the	DET
gs-3799	170	2	demand	demand	NOUN
gs-3799	170	3	for	for	ADP
gs-3799	170	4	closed	closed	ADJ
gs-3799	170	5	-	-	PUNCT
gs-3799	170	6	loop	loop	NOUN
gs-3799	170	7	systems	system	NOUN
gs-3799	170	8	in	in	ADP
gs-3799	170	9	cpb	cpb	PROPN
gs-3799	170	10	arises	arise	VERB
gs-3799	170	11	from	from	ADP
gs-3799	170	12	the	the	DET
gs-3799	170	13	persistent	persistent	ADJ
gs-3799	170	14	challenge	challenge	NOUN
gs-3799	170	15	of	of	ADP
gs-3799	170	16	achieving	achieve	VERB
gs-3799	170	17	optimal	optimal	ADJ
gs-3799	170	18	physiological	physiological	ADJ
gs-3799	170	19	regulation	regulation	NOUN
gs-3799	170	20	during	during	ADP
gs-3799	170	21	surgery	surgery	NOUN
gs-3799	170	22	,	,	PUNCT
gs-3799	170	23	minimizing	minimize	VERB
gs-3799	170	24	postoperative	postoperative	ADJ
gs-3799	170	25	complications	complication	NOUN
gs-3799	170	26	,	,	PUNCT
gs-3799	170	27	and	and	CCONJ
gs-3799	170	28	individualizing	individualize	VERB
gs-3799	170	29	patient	patient	ADJ
gs-3799	170	30	management	management	NOUN
gs-3799	170	31	.	.	PUNCT
gs-3799	171	1	these	these	DET
gs-3799	171	2	advanced	advanced	ADJ
gs-3799	171	3	systems	system	NOUN
gs-3799	171	4	are	be	AUX
gs-3799	171	5	designed	design	VERB
gs-3799	171	6	not	not	PART
gs-3799	171	7	merely	merely	ADV
gs-3799	171	8	to	to	PART
gs-3799	171	9	replace	replace	VERB
gs-3799	171	10	cardiac	cardiac	ADJ
gs-3799	171	11	and	and	CCONJ
gs-3799	171	12	pulmonary	pulmonary	ADJ
gs-3799	171	13	functions	function	NOUN
gs-3799	171	14	temporarily	temporarily	ADV
gs-3799	171	15	,	,	PUNCT
gs-3799	171	16	but	but	CCONJ
gs-3799	171	17	to	to	PART
gs-3799	171	18	do	do	VERB
gs-3799	171	19	so	so	ADV
gs-3799	171	20	with	with	SCONJ
gs-3799	171	21	a	a	DET
gs-3799	171	22	level	level	NOUN
gs-3799	171	23	of	of	ADP
gs-3799	171	24	precision	precision	NOUN
gs-3799	171	25	and	and	CCONJ
gs-3799	171	26	responsiveness	responsiveness	NOUN
gs-3799	171	27	previously	previously	ADV
gs-3799	171	28	unattainable	unattainable	ADJ
gs-3799	171	29	.	.	PUNCT
gs-3799	172	1	the	the	DET
gs-3799	172	2	fusion	fusion	NOUN
gs-3799	172	3	of	of	ADP
gs-3799	172	4	automated	automate	VERB
gs-3799	172	5	control	control	NOUN
gs-3799	172	6	with	with	ADP
gs-3799	172	7	realtime	realtime	NOUN
gs-3799	172	8	monitoring	monitoring	NOUN
gs-3799	172	9	and	and	CCONJ
gs-3799	172	10	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	172	11	creates	create	VERB
gs-3799	172	12	an	an	DET
gs-3799	172	13	opportunity	opportunity	NOUN
gs-3799	172	14	to	to	PART
gs-3799	172	15	refine	refine	VERB
gs-3799	172	16	cardiovascular	cardiovascular	ADJ
gs-3799	172	17	support	support	NOUN
gs-3799	172	18	into	into	ADP
gs-3799	172	19	a	a	DET
gs-3799	172	20	more	more	ADV
gs-3799	172	21	predictive	predictive	ADJ
gs-3799	172	22	,	,	PUNCT
gs-3799	172	23	adaptive	adaptive	ADJ
gs-3799	172	24	,	,	PUNCT
gs-3799	172	25	and	and	CCONJ
gs-3799	172	26	safer	safe	ADJ
gs-3799	172	27	modality	modality	NOUN
gs-3799	172	28	.	.	PUNCT
gs-3799	173	1	the	the	DET
gs-3799	173	2	impetus	impetus	NOUN
gs-3799	173	3	for	for	ADP
gs-3799	173	4	developing	develop	VERB
gs-3799	173	5	closed	closed	ADJ
gs-3799	173	6	-	-	PUNCT
gs-3799	173	7	loop	loop	NOUN
gs-3799	173	8	cpb	cpb	NOUN
gs-3799	173	9	systems	system	NOUN
gs-3799	173	10	originates	originate	NOUN
gs-3799	173	11	from	from	ADP
gs-3799	173	12	the	the	DET
gs-3799	173	13	limitations	limitation	NOUN
gs-3799	173	14	inherent	inherent	ADJ
gs-3799	173	15	in	in	ADP
gs-3799	173	16	traditional	traditional	ADJ
gs-3799	173	17	open	open	ADJ
gs-3799	173	18	-	-	PUNCT
gs-3799	173	19	loop	loop	NOUN
gs-3799	173	20	techniques	technique	NOUN
gs-3799	173	21	.	.	PUNCT
gs-3799	174	1	manual	manual	ADJ
gs-3799	174	2	regulation	regulation	NOUN
gs-3799	174	3	of	of	ADP
gs-3799	174	4	perfusion	perfusion	NOUN
gs-3799	174	5	parameters	parameter	NOUN
gs-3799	174	6	often	often	ADV
gs-3799	174	7	relies	rely	VERB
gs-3799	174	8	on	on	ADP
gs-3799	174	9	the	the	DET
gs-3799	174	10	operator	operator	NOUN
gs-3799	174	11	's	's	PART
gs-3799	174	12	experience	experience	NOUN
gs-3799	174	13	,	,	PUNCT
gs-3799	174	14	the	the	DET
gs-3799	174	15	availability	availability	NOUN
gs-3799	174	16	of	of	ADP
gs-3799	174	17	periodic	periodic	ADJ
gs-3799	174	18	lab	lab	NOUN
gs-3799	174	19	data	datum	NOUN
gs-3799	174	20	,	,	PUNCT
gs-3799	174	21	and	and	CCONJ
gs-3799	174	22	institutional	institutional	ADJ
gs-3799	174	23	protocols	protocol	NOUN
gs-3799	174	24	that	that	PRON
gs-3799	174	25	may	may	AUX
gs-3799	174	26	not	not	PART
gs-3799	174	27	reflect	reflect	VERB
gs-3799	174	28	patient	patient	NOUN
gs-3799	174	29	-	-	PUNCT
gs-3799	174	30	specific	specific	ADJ
gs-3799	174	31	needs	need	NOUN
gs-3799	174	32	in	in	ADP
gs-3799	174	33	real	real	ADJ
gs-3799	174	34	time	time	NOUN
gs-3799	174	35	.	.	PUNCT
gs-3799	175	1	such	such	ADJ
gs-3799	175	2	approaches	approach	NOUN
gs-3799	175	3	can	can	AUX
gs-3799	175	4	result	result	VERB
gs-3799	175	5	in	in	ADP
gs-3799	175	6	inconsistent	inconsistent	ADJ
gs-3799	175	7	management	management	NOUN
gs-3799	175	8	of	of	ADP
gs-3799	175	9	critical	critical	ADJ
gs-3799	175	10	parameters	parameter	NOUN
gs-3799	175	11	such	such	ADJ
gs-3799	175	12	as	as	ADP
gs-3799	175	13	perfusion	perfusion	NOUN
gs-3799	175	14	pressure	pressure	NOUN
gs-3799	175	15	,	,	PUNCT
gs-3799	175	16	oxygen	oxygen	NOUN
gs-3799	175	17	delivery	delivery	NOUN
gs-3799	175	18	,	,	PUNCT
gs-3799	175	19	hematocrit	hematocrit	NOUN
gs-3799	175	20	,	,	PUNCT
gs-3799	175	21	and	and	CCONJ
gs-3799	175	22	systemic	systemic	ADJ
gs-3799	175	23	vascular	vascular	ADJ
gs-3799	175	24	resistance	resistance	NOUN
gs-3799	175	25	.	.	PUNCT
gs-3799	176	1	this	this	DET
gs-3799	176	2	inconsistency	inconsistency	NOUN
gs-3799	176	3	can	can	AUX
gs-3799	176	4	contribute	contribute	VERB
gs-3799	176	5	to	to	ADP
gs-3799	176	6	avoidable	avoidable	ADJ
gs-3799	176	7	ischemic	ischemic	ADJ
gs-3799	176	8	insults	insult	NOUN
gs-3799	176	9	,	,	PUNCT
gs-3799	176	10	inflammatory	inflammatory	ADJ
gs-3799	176	11	responses	response	NOUN
gs-3799	176	12	,	,	PUNCT
gs-3799	176	13	and	and	CCONJ
gs-3799	176	14	coagulopathy	coagulopathy	ADJ
gs-3799	176	15	,	,	PUNCT
gs-3799	176	16	and	and	CCONJ
gs-3799	176	17	neurologic	neurologic	ADJ
gs-3799	176	18	injury	injury	NOUN
gs-3799	176	19	—	—	PUNCT
gs-3799	176	20	common	common	ADJ
gs-3799	176	21	sequelae	sequelae	NOUN
gs-3799	176	22	of	of	ADP
gs-3799	176	23	suboptimal	suboptimal	ADJ
gs-3799	176	24	bypass	bypass	NOUN
gs-3799	176	25	strategies	strategy	NOUN
gs-3799	176	26	.	.	PUNCT
gs-3799	177	1	a	a	DET
gs-3799	177	2	closedloop	closedloop	NOUN
gs-3799	177	3	framework	framework	NOUN
gs-3799	177	4	offers	offer	VERB
gs-3799	177	5	the	the	DET
gs-3799	177	6	theoretical	theoretical	ADJ
gs-3799	177	7	advantage	advantage	NOUN
gs-3799	177	8	of	of	ADP
gs-3799	177	9	minimizing	minimize	VERB
gs-3799	177	10	these	these	DET
gs-3799	177	11	risks	risk	NOUN
gs-3799	177	12	by	by	ADP
gs-3799	177	13	ensuring	ensure	VERB
gs-3799	177	14	continuous	continuous	ADJ
gs-3799	177	15	feedback	feedback	NOUN
gs-3799	177	16	,	,	PUNCT
gs-3799	177	17	algorithm	algorithm	NOUN
gs-3799	177	18	-	-	PUNCT
gs-3799	177	19	driven	drive	VERB
gs-3799	177	20	decision	decision	NOUN
gs-3799	177	21	-	-	PUNCT
gs-3799	177	22	making	making	NOUN
gs-3799	177	23	,	,	PUNCT
gs-3799	177	24	and	and	CCONJ
gs-3799	177	25	rapid	rapid	ADJ
gs-3799	177	26	therapeutic	therapeutic	ADJ
gs-3799	177	27	adjustments	adjustment	NOUN
gs-3799	177	28	.	.	PUNCT
gs-3799	178	1	georgian	georgian	NOUN
gs-3799	178	2	scientists/	scientists/	NUM
gs-3799	178	3	.	.	PUNCT
gs-3799	179	1	7	7	NUM
gs-3799	179	2	n	n	PRON
gs-3799	179	3	2	2	NUM
gs-3799	179	4	,	,	PUNCT
gs-3799	179	5	2025	2025	NUM
gs-3799	179	6	390	390	NUM
gs-3799	179	7	at	at	ADP
gs-3799	179	8	the	the	DET
gs-3799	179	9	heart	heart	NOUN
gs-3799	179	10	of	of	ADP
gs-3799	179	11	a	a	DET
gs-3799	179	12	closed	closed	ADJ
gs-3799	179	13	-	-	PUNCT
gs-3799	179	14	loop	loop	NOUN
gs-3799	179	15	cpb	cpb	NOUN
gs-3799	179	16	system	system	NOUN
gs-3799	179	17	lies	lie	VERB
gs-3799	179	18	the	the	DET
gs-3799	179	19	integration	integration	NOUN
gs-3799	179	20	of	of	ADP
gs-3799	179	21	advanced	advanced	ADJ
gs-3799	179	22	monitoring	monitoring	NOUN
gs-3799	179	23	technologies	technology	NOUN
gs-3799	179	24	that	that	PRON
gs-3799	179	25	capture	capture	VERB
gs-3799	179	26	real	real	ADJ
gs-3799	179	27	-	-	PUNCT
gs-3799	179	28	time	time	NOUN
gs-3799	179	29	physiologic	physiologic	ADJ
gs-3799	179	30	data	datum	NOUN
gs-3799	179	31	with	with	ADP
gs-3799	179	32	high	high	ADJ
gs-3799	179	33	temporal	temporal	ADJ
gs-3799	179	34	resolution	resolution	NOUN
gs-3799	179	35	.	.	PUNCT
gs-3799	180	1	these	these	PRON
gs-3799	180	2	include	include	VERB
gs-3799	180	3	continuous	continuous	ADJ
gs-3799	180	4	arterial	arterial	ADJ
gs-3799	180	5	blood	blood	NOUN
gs-3799	180	6	gas	gas	NOUN
gs-3799	180	7	monitoring	monitoring	NOUN
gs-3799	180	8	,	,	PUNCT
gs-3799	180	9	non	non	ADJ
gs-3799	180	10	-	-	ADJ
gs-3799	180	11	invasive	invasive	ADJ
gs-3799	180	12	cerebral	cerebral	ADJ
gs-3799	180	13	oximetry	oximetry	NOUN
gs-3799	180	14	,	,	PUNCT
gs-3799	180	15	mixed	mixed	ADJ
gs-3799	180	16	venous	venous	ADJ
gs-3799	180	17	oxygen	oxygen	NOUN
gs-3799	180	18	saturation	saturation	NOUN
gs-3799	180	19	,	,	PUNCT
gs-3799	180	20	near	near	ADV
gs-3799	180	21	-	-	PUNCT
gs-3799	180	22	infrared	infrared	ADJ
gs-3799	180	23	spectroscopy	spectroscopy	NOUN
gs-3799	180	24	,	,	PUNCT
gs-3799	180	25	hemodynamic	hemodynamic	ADJ
gs-3799	180	26	flow	flow	NOUN
gs-3799	180	27	sensors	sensor	NOUN
gs-3799	180	28	,	,	PUNCT
gs-3799	180	29	and	and	CCONJ
gs-3799	180	30	advanced	advanced	ADJ
gs-3799	180	31	temperature	temperature	NOUN
gs-3799	180	32	regulation	regulation	NOUN
gs-3799	180	33	feedback	feedback	NOUN
gs-3799	180	34	loops	loop	NOUN
gs-3799	180	35	.	.	PUNCT
gs-3799	181	1	these	these	DET
gs-3799	181	2	devices	device	NOUN
gs-3799	181	3	feed	feed	VERB
gs-3799	181	4	high	high	ADJ
gs-3799	181	5	-	-	PUNCT
gs-3799	181	6	frequency	frequency	NOUN
gs-3799	181	7	data	datum	NOUN
gs-3799	181	8	into	into	ADP
gs-3799	181	9	a	a	DET
gs-3799	181	10	central	central	ADJ
gs-3799	181	11	processing	processing	NOUN
gs-3799	181	12	unit	unit	NOUN
gs-3799	181	13	that	that	PRON
gs-3799	181	14	employs	employ	VERB
gs-3799	181	15	machine	machine	NOUN
gs-3799	181	16	learning	learning	NOUN
gs-3799	181	17	,	,	PUNCT
gs-3799	181	18	predictive	predictive	ADJ
gs-3799	181	19	modeling	modeling	NOUN
gs-3799	181	20	,	,	PUNCT
gs-3799	181	21	or	or	CCONJ
gs-3799	181	22	rule	rule	NOUN
gs-3799	181	23	-	-	PUNCT
gs-3799	181	24	based	base	VERB
gs-3799	181	25	algorithms	algorithm	NOUN
gs-3799	181	26	to	to	PART
gs-3799	181	27	compare	compare	VERB
gs-3799	181	28	actual	actual	ADJ
gs-3799	181	29	versus	versus	ADP
gs-3799	181	30	desired	desire	VERB
gs-3799	181	31	physiologic	physiologic	ADJ
gs-3799	181	32	states	state	NOUN
gs-3799	181	33	.	.	PUNCT
gs-3799	182	1	this	this	DET
gs-3799	182	2	comparison	comparison	NOUN
gs-3799	182	3	initiates	initiate	VERB
gs-3799	182	4	automated	automate	VERB
gs-3799	182	5	adjustments	adjustment	NOUN
gs-3799	182	6	in	in	ADP
gs-3799	182	7	pump	pump	NOUN
gs-3799	182	8	speed	speed	NOUN
gs-3799	182	9	,	,	PUNCT
gs-3799	182	10	oxygenator	oxygenator	NOUN
gs-3799	182	11	performance	performance	NOUN
gs-3799	182	12	,	,	PUNCT
gs-3799	182	13	drug	drug	NOUN
gs-3799	182	14	infusion	infusion	NOUN
gs-3799	182	15	rates	rate	NOUN
gs-3799	182	16	,	,	PUNCT
gs-3799	182	17	and	and	CCONJ
gs-3799	182	18	fluid	fluid	ADJ
gs-3799	182	19	delivery	delivery	NOUN
gs-3799	182	20	,	,	PUNCT
gs-3799	182	21	maintaining	maintain	VERB
gs-3799	182	22	a	a	DET
gs-3799	182	23	tightly	tightly	ADV
gs-3799	182	24	regulated	regulate	VERB
gs-3799	182	25	physiologic	physiologic	ADJ
gs-3799	182	26	environment	environment	NOUN
gs-3799	182	27	throughout	throughout	ADP
gs-3799	182	28	the	the	DET
gs-3799	182	29	surgical	surgical	ADJ
gs-3799	182	30	procedure	procedure	NOUN
gs-3799	182	31	.	.	PUNCT
gs-3799	183	1	pharmacologic	pharmacologic	ADJ
gs-3799	183	2	modulation	modulation	NOUN
gs-3799	183	3	within	within	ADP
gs-3799	183	4	closed	closed	ADJ
gs-3799	183	5	-	-	PUNCT
gs-3799	183	6	loop	loop	NOUN
gs-3799	183	7	systems	system	NOUN
gs-3799	183	8	introduces	introduce	VERB
gs-3799	183	9	a	a	DET
gs-3799	183	10	novel	novel	ADJ
gs-3799	183	11	dimension	dimension	NOUN
gs-3799	183	12	to	to	ADP
gs-3799	183	13	bypass	bypass	NOUN
gs-3799	183	14	management	management	NOUN
gs-3799	183	15	.	.	PUNCT
gs-3799	184	1	real	real	ADJ
gs-3799	184	2	-	-	PUNCT
gs-3799	184	3	time	time	NOUN
gs-3799	184	4	infusion	infusion	NOUN
gs-3799	184	5	of	of	ADP
gs-3799	184	6	vasoactive	vasoactive	ADJ
gs-3799	184	7	agents	agent	NOUN
gs-3799	184	8	,	,	PUNCT
gs-3799	184	9	anticoagulants	anticoagulant	NOUN
gs-3799	184	10	,	,	PUNCT
gs-3799	184	11	anti	anti	ADJ
gs-3799	184	12	-	-	ADJ
gs-3799	184	13	inflammatory	inflammatory	ADJ
gs-3799	184	14	drugs	drug	NOUN
gs-3799	184	15	,	,	PUNCT
gs-3799	184	16	and	and	CCONJ
gs-3799	184	17	metabolic	metabolic	NOUN
gs-3799	184	18	regulators	regulator	NOUN
gs-3799	184	19	can	can	AUX
gs-3799	184	20	now	now	ADV
gs-3799	184	21	be	be	AUX
gs-3799	184	22	titrated	titrate	VERB
gs-3799	184	23	in	in	ADP
gs-3799	184	24	response	response	NOUN
gs-3799	184	25	to	to	ADP
gs-3799	184	26	continuous	continuous	ADJ
gs-3799	184	27	data	datum	NOUN
gs-3799	184	28	streams	stream	NOUN
gs-3799	184	29	.	.	PUNCT
gs-3799	185	1	this	this	DET
gs-3799	185	2	active	active	ADJ
gs-3799	185	3	control	control	NOUN
gs-3799	185	4	of	of	ADP
gs-3799	185	5	pharmacodynamics	pharmacodynamic	NOUN
gs-3799	185	6	offers	offer	VERB
gs-3799	185	7	a	a	DET
gs-3799	185	8	way	way	NOUN
gs-3799	185	9	to	to	PART
gs-3799	185	10	preemptively	preemptively	ADV
gs-3799	185	11	modulate	modulate	VERB
gs-3799	185	12	systemic	systemic	ADJ
gs-3799	185	13	vascular	vascular	ADJ
gs-3799	185	14	resistance	resistance	NOUN
gs-3799	185	15	,	,	PUNCT
gs-3799	185	16	optimize	optimize	VERB
gs-3799	185	17	myocardial	myocardial	ADJ
gs-3799	185	18	protection	protection	NOUN
gs-3799	185	19	,	,	PUNCT
gs-3799	185	20	stabilize	stabilize	VERB
gs-3799	185	21	coagulation	coagulation	NOUN
gs-3799	185	22	parameters	parameter	NOUN
gs-3799	185	23	,	,	PUNCT
gs-3799	185	24	and	and	CCONJ
gs-3799	185	25	suppress	suppress	VERB
gs-3799	185	26	adverse	adverse	ADJ
gs-3799	185	27	inflammatory	inflammatory	ADJ
gs-3799	185	28	pathways	pathway	NOUN
gs-3799	185	29	.	.	PUNCT
gs-3799	186	1	the	the	DET
gs-3799	186	2	capacity	capacity	NOUN
gs-3799	186	3	to	to	PART
gs-3799	186	4	integrate	integrate	VERB
gs-3799	186	5	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	186	6	within	within	ADP
gs-3799	186	7	the	the	DET
gs-3799	186	8	closed	closed	ADJ
gs-3799	186	9	-	-	PUNCT
gs-3799	186	10	loop	loop	NOUN
gs-3799	186	11	circuit	circuit	NOUN
gs-3799	186	12	is	be	AUX
gs-3799	186	13	a	a	DET
gs-3799	186	14	paradigm	paradigm	NOUN
gs-3799	186	15	shift	shift	NOUN
gs-3799	186	16	,	,	PUNCT
gs-3799	186	17	transforming	transform	VERB
gs-3799	186	18	cpb	cpb	NOUN
gs-3799	186	19	from	from	ADP
gs-3799	186	20	a	a	DET
gs-3799	186	21	mechanical	mechanical	ADJ
gs-3799	186	22	support	support	NOUN
gs-3799	186	23	system	system	NOUN
gs-3799	186	24	to	to	ADP
gs-3799	186	25	a	a	DET
gs-3799	186	26	bio	bio	ADJ
gs-3799	186	27	-	-	ADJ
gs-3799	186	28	interactive	interactive	ADJ
gs-3799	186	29	platform	platform	NOUN
gs-3799	186	30	capable	capable	ADJ
gs-3799	186	31	of	of	ADP
gs-3799	186	32	fine	fine	ADV
gs-3799	186	33	-	-	PUNCT
gs-3799	186	34	tuned	tune	VERB
gs-3799	186	35	therapeutic	therapeutic	ADJ
gs-3799	186	36	delivery	delivery	NOUN
gs-3799	186	37	.	.	PUNCT
gs-3799	187	1	the	the	DET
gs-3799	187	2	development	development	NOUN
gs-3799	187	3	of	of	ADP
gs-3799	187	4	such	such	ADJ
gs-3799	187	5	systems	system	NOUN
gs-3799	187	6	has	have	AUX
gs-3799	187	7	been	be	AUX
gs-3799	187	8	spurred	spur	VERB
gs-3799	187	9	by	by	ADP
gs-3799	187	10	interdisciplinary	interdisciplinary	ADJ
gs-3799	187	11	collaboration	collaboration	NOUN
gs-3799	187	12	among	among	ADP
gs-3799	187	13	bioengineers	bioengineer	NOUN
gs-3799	187	14	,	,	PUNCT
gs-3799	187	15	perfusionists	perfusionist	NOUN
gs-3799	187	16	,	,	PUNCT
gs-3799	187	17	anesthesiologists	anesthesiologist	NOUN
gs-3799	187	18	,	,	PUNCT
gs-3799	187	19	intensivists	intensivist	NOUN
gs-3799	187	20	,	,	PUNCT
gs-3799	187	21	and	and	CCONJ
gs-3799	187	22	pharmacologists	pharmacologist	NOUN
gs-3799	187	23	.	.	PUNCT
gs-3799	188	1	their	their	PRON
gs-3799	188	2	collective	collective	ADJ
gs-3799	188	3	efforts	effort	NOUN
gs-3799	188	4	have	have	AUX
gs-3799	188	5	led	lead	VERB
gs-3799	188	6	to	to	ADP
gs-3799	188	7	prototypes	prototype	NOUN
gs-3799	188	8	and	and	CCONJ
gs-3799	188	9	pilot	pilot	NOUN
gs-3799	188	10	implementations	implementation	NOUN
gs-3799	188	11	that	that	PRON
gs-3799	188	12	demonstrate	demonstrate	VERB
gs-3799	188	13	proof	proof	NOUN
gs-3799	188	14	of	of	ADP
gs-3799	188	15	concept	concept	NOUN
gs-3799	188	16	in	in	ADP
gs-3799	188	17	both	both	CCONJ
gs-3799	188	18	experimental	experimental	ADJ
gs-3799	188	19	and	and	CCONJ
gs-3799	188	20	early	early	ADJ
gs-3799	188	21	clinical	clinical	ADJ
gs-3799	188	22	settings	setting	NOUN
gs-3799	188	23	.	.	PUNCT
gs-3799	189	1	these	these	DET
gs-3799	189	2	models	model	NOUN
gs-3799	189	3	reveal	reveal	VERB
gs-3799	189	4	significant	significant	ADJ
gs-3799	189	5	potential	potential	NOUN
gs-3799	189	6	for	for	ADP
gs-3799	189	7	reducing	reduce	VERB
gs-3799	189	8	bypassassociated	bypassassociate	VERB
gs-3799	189	9	complications	complication	NOUN
gs-3799	189	10	,	,	PUNCT
gs-3799	189	11	standardizing	standardize	VERB
gs-3799	189	12	intraoperative	intraoperative	ADJ
gs-3799	189	13	management	management	NOUN
gs-3799	189	14	,	,	PUNCT
gs-3799	189	15	and	and	CCONJ
gs-3799	189	16	improving	improve	VERB
gs-3799	189	17	patient	patient	ADJ
gs-3799	189	18	outcomes	outcome	NOUN
gs-3799	189	19	.	.	PUNCT
gs-3799	190	1	however	however	ADV
gs-3799	190	2	,	,	PUNCT
gs-3799	190	3	despite	despite	SCONJ
gs-3799	190	4	these	these	DET
gs-3799	190	5	advancements	advancement	NOUN
gs-3799	190	6	,	,	PUNCT
gs-3799	190	7	widespread	widespread	ADJ
gs-3799	190	8	clinical	clinical	ADJ
gs-3799	190	9	adoption	adoption	NOUN
gs-3799	190	10	remains	remain	VERB
gs-3799	190	11	limited	limited	ADJ
gs-3799	190	12	,	,	PUNCT
gs-3799	190	13	primarily	primarily	ADV
gs-3799	190	14	due	due	ADJ
gs-3799	190	15	to	to	ADP
gs-3799	190	16	regulatory	regulatory	ADJ
gs-3799	190	17	,	,	PUNCT
gs-3799	190	18	logistical	logistical	ADJ
gs-3799	190	19	,	,	PUNCT
gs-3799	190	20	and	and	CCONJ
gs-3799	190	21	interoperability	interoperability	NOUN
gs-3799	190	22	challenges	challenge	NOUN
gs-3799	190	23	.	.	PUNCT
gs-3799	191	1	central	central	ADJ
gs-3799	191	2	to	to	ADP
gs-3799	191	3	the	the	DET
gs-3799	191	4	success	success	NOUN
gs-3799	191	5	of	of	ADP
gs-3799	191	6	any	any	DET
gs-3799	191	7	closed	closed	ADJ
gs-3799	191	8	-	-	PUNCT
gs-3799	191	9	loop	loop	NOUN
gs-3799	191	10	cpb	cpb	NOUN
gs-3799	191	11	system	system	NOUN
gs-3799	191	12	is	be	AUX
gs-3799	191	13	its	its	PRON
gs-3799	191	14	ability	ability	NOUN
gs-3799	191	15	to	to	PART
gs-3799	191	16	handle	handle	VERB
gs-3799	191	17	the	the	DET
gs-3799	191	18	complexity	complexity	NOUN
gs-3799	191	19	and	and	CCONJ
gs-3799	191	20	interconnectivity	interconnectivity	NOUN
gs-3799	191	21	of	of	ADP
gs-3799	191	22	human	human	ADJ
gs-3799	191	23	physiology	physiology	NOUN
gs-3799	191	24	under	under	ADP
gs-3799	191	25	stress	stress	NOUN
gs-3799	191	26	.	.	PUNCT
gs-3799	192	1	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	192	2	bypass	bypass	NOUN
gs-3799	192	3	induces	induce	VERB
gs-3799	192	4	profound	profound	ADJ
gs-3799	192	5	alterations	alteration	NOUN
gs-3799	192	6	in	in	ADP
gs-3799	192	7	homeostasis	homeostasis	NOUN
gs-3799	192	8	,	,	PUNCT
gs-3799	192	9	including	include	VERB
gs-3799	192	10	inflammatory	inflammatory	ADJ
gs-3799	192	11	cascades	cascade	NOUN
gs-3799	192	12	,	,	PUNCT
gs-3799	192	13	hormonal	hormonal	ADJ
gs-3799	192	14	dysregulation	dysregulation	NOUN
gs-3799	192	15	,	,	PUNCT
gs-3799	192	16	fluid	fluid	ADJ
gs-3799	192	17	shifts	shift	NOUN
gs-3799	192	18	,	,	PUNCT
gs-3799	192	19	and	and	CCONJ
gs-3799	192	20	organ	organ	NOUN
gs-3799	192	21	-	-	PUNCT
gs-3799	192	22	specific	specific	ADJ
gs-3799	192	23	ischemia	ischemia	NOUN
gs-3799	192	24	-	-	PUNCT
gs-3799	192	25	reperfusion	reperfusion	NOUN
gs-3799	192	26	phenomena	phenomenon	NOUN
gs-3799	192	27	.	.	PUNCT
gs-3799	193	1	thus	thus	ADV
gs-3799	193	2	,	,	PUNCT
gs-3799	193	3	closed	closed	ADJ
gs-3799	193	4	-	-	PUNCT
gs-3799	193	5	loop	loop	NOUN
gs-3799	193	6	systems	system	NOUN
gs-3799	193	7	must	must	AUX
gs-3799	193	8	not	not	PART
gs-3799	193	9	only	only	ADV
gs-3799	193	10	manage	manage	VERB
gs-3799	193	11	baseline	baseline	ADJ
gs-3799	193	12	parameters	parameter	NOUN
gs-3799	193	13	but	but	CCONJ
gs-3799	193	14	also	also	ADV
gs-3799	193	15	recognize	recognize	VERB
gs-3799	193	16	and	and	CCONJ
gs-3799	193	17	adapt	adapt	VERB
gs-3799	193	18	to	to	ADP
gs-3799	193	19	dynamic	dynamic	ADJ
gs-3799	193	20	intraoperative	intraoperative	ADJ
gs-3799	193	21	events	event	NOUN
gs-3799	193	22	such	such	ADJ
gs-3799	193	23	as	as	ADP
gs-3799	193	24	bleeding	bleed	VERB
gs-3799	193	25	,	,	PUNCT
gs-3799	193	26	temperature	temperature	NOUN
gs-3799	193	27	fluctuations	fluctuation	NOUN
gs-3799	193	28	,	,	PUNCT
gs-3799	193	29	arrhythmias	arrhythmia	NOUN
gs-3799	193	30	,	,	PUNCT
gs-3799	193	31	and	and	CCONJ
gs-3799	193	32	sudden	sudden	ADJ
gs-3799	193	33	changes	change	NOUN
gs-3799	193	34	in	in	ADP
gs-3799	193	35	vascular	vascular	ADJ
gs-3799	193	36	tone	tone	NOUN
gs-3799	193	37	.	.	PUNCT
gs-3799	194	1	this	this	PRON
gs-3799	194	2	necessitates	necessitate	VERB
gs-3799	194	3	robust	robust	ADJ
gs-3799	194	4	sensor	sensor	NOUN
gs-3799	194	5	fidelity	fidelity	NOUN
gs-3799	194	6	,	,	PUNCT
gs-3799	194	7	resilient	resilient	ADJ
gs-3799	194	8	algorithm	algorithm	NOUN
gs-3799	194	9	design	design	NOUN
gs-3799	194	10	,	,	PUNCT
gs-3799	194	11	and	and	CCONJ
gs-3799	194	12	high	high	ADJ
gs-3799	194	13	-	-	PUNCT
gs-3799	194	14	frequency	frequency	NOUN
gs-3799	194	15	data	datum	NOUN
gs-3799	194	16	integration	integration	NOUN
gs-3799	194	17	—	—	PUNCT
gs-3799	194	18	all	all	PRON
gs-3799	194	19	of	of	ADP
gs-3799	194	20	which	which	PRON
gs-3799	194	21	require	require	VERB
gs-3799	194	22	rigorous	rigorous	ADJ
gs-3799	194	23	testing	testing	NOUN
gs-3799	194	24	under	under	ADP
gs-3799	194	25	varied	varied	ADJ
gs-3799	194	26	surgical	surgical	ADJ
gs-3799	194	27	conditions	condition	NOUN
gs-3799	194	28	.	.	PUNCT
gs-3799	195	1	another	another	DET
gs-3799	195	2	crucial	crucial	ADJ
gs-3799	195	3	challenge	challenge	NOUN
gs-3799	195	4	is	be	AUX
gs-3799	195	5	the	the	DET
gs-3799	195	6	standardization	standardization	NOUN
gs-3799	195	7	of	of	ADP
gs-3799	195	8	data	datum	NOUN
gs-3799	195	9	formats	format	NOUN
gs-3799	195	10	and	and	CCONJ
gs-3799	195	11	system	system	NOUN
gs-3799	195	12	architecture	architecture	NOUN
gs-3799	195	13	across	across	ADP
gs-3799	195	14	different	different	ADJ
gs-3799	195	15	monitoring	monitoring	NOUN
gs-3799	195	16	platforms	platform	NOUN
gs-3799	195	17	and	and	CCONJ
gs-3799	195	18	surgical	surgical	ADJ
gs-3799	195	19	devices	device	NOUN
gs-3799	195	20	.	.	PUNCT
gs-3799	196	1	the	the	DET
gs-3799	196	2	lack	lack	NOUN
gs-3799	196	3	of	of	ADP
gs-3799	196	4	unified	unified	ADJ
gs-3799	196	5	communication	communication	NOUN
gs-3799	196	6	protocols	protocol	NOUN
gs-3799	196	7	hampers	hamper	VERB
gs-3799	196	8	the	the	DET
gs-3799	196	9	seamless	seamless	ADJ
gs-3799	196	10	exchange	exchange	NOUN
gs-3799	196	11	of	of	ADP
gs-3799	196	12	information	information	NOUN
gs-3799	196	13	among	among	ADP
gs-3799	196	14	system	system	NOUN
gs-3799	196	15	components	component	NOUN
gs-3799	196	16	,	,	PUNCT
gs-3799	196	17	complicating	complicate	VERB
gs-3799	196	18	the	the	DET
gs-3799	196	19	construction	construction	NOUN
gs-3799	196	20	of	of	ADP
gs-3799	196	21	truly	truly	ADV
gs-3799	196	22	integrated	integrate	VERB
gs-3799	196	23	feedback	feedback	NOUN
gs-3799	196	24	systems	system	NOUN
gs-3799	196	25	.	.	PUNCT
gs-3799	197	1	furthermore	furthermore	ADV
gs-3799	197	2	,	,	PUNCT
gs-3799	197	3	differences	difference	NOUN
gs-3799	197	4	in	in	ADP
gs-3799	197	5	patient	patient	ADJ
gs-3799	197	6	physiology	physiology	NOUN
gs-3799	197	7	and	and	CCONJ
gs-3799	197	8	comorbidities	comorbiditie	NOUN
gs-3799	197	9	necessitate	necessitate	ADJ
gs-3799	197	10	flexible	flexible	ADJ
gs-3799	197	11	,	,	PUNCT
gs-3799	197	12	patient	patient	NOUN
gs-3799	197	13	-	-	PUNCT
gs-3799	197	14	specific	specific	ADJ
gs-3799	197	15	algorithm	algorithm	NOUN
gs-3799	197	16	calibration	calibration	NOUN
gs-3799	197	17	,	,	PUNCT
gs-3799	197	18	which	which	PRON
gs-3799	197	19	remains	remain	VERB
gs-3799	197	20	a	a	DET
gs-3799	197	21	complex	complex	ADJ
gs-3799	197	22	and	and	CCONJ
gs-3799	197	23	underdeveloped	underdeveloped	ADJ
gs-3799	197	24	domain	domain	NOUN
gs-3799	197	25	.	.	PUNCT
gs-3799	198	1	the	the	DET
gs-3799	198	2	balance	balance	NOUN
gs-3799	198	3	between	between	ADP
gs-3799	198	4	automation	automation	NOUN
gs-3799	198	5	and	and	CCONJ
gs-3799	198	6	human	human	ADJ
gs-3799	198	7	oversight	oversight	NOUN
gs-3799	198	8	is	be	AUX
gs-3799	198	9	also	also	ADV
gs-3799	198	10	delicate	delicate	ADJ
gs-3799	198	11	—	—	PUNCT
gs-3799	198	12	too	too	ADV
gs-3799	198	13	much	much	ADJ
gs-3799	198	14	automation	automation	NOUN
gs-3799	198	15	could	could	AUX
gs-3799	198	16	obscure	obscure	VERB
gs-3799	198	17	clinical	clinical	ADJ
gs-3799	198	18	judgment	judgment	NOUN
gs-3799	198	19	,	,	PUNCT
gs-3799	198	20	while	while	SCONJ
gs-3799	198	21	too	too	ADV
gs-3799	198	22	little	little	ADJ
gs-3799	198	23	limits	limit	NOUN
gs-3799	198	24	the	the	DET
gs-3799	198	25	system	system	NOUN
gs-3799	198	26	’s	’s	PART
gs-3799	198	27	responsiveness	responsiveness	NOUN
gs-3799	198	28	and	and	CCONJ
gs-3799	198	29	reliability	reliability	NOUN
gs-3799	198	30	.	.	PUNCT
gs-3799	199	1	georgian	georgian	NOUN
gs-3799	199	2	scientists/	scientists/	NUM
gs-3799	199	3	.	.	PUNCT
gs-3799	200	1	7	7	NUM
gs-3799	200	2	n	n	PRON
gs-3799	200	3	2	2	NUM
gs-3799	200	4	,	,	PUNCT
gs-3799	200	5	2025	2025	NUM
gs-3799	200	6	391	391	NUM
gs-3799	200	7	from	from	ADP
gs-3799	200	8	a	a	DET
gs-3799	200	9	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-3799	200	10	standpoint	standpoint	NOUN
gs-3799	200	11	,	,	PUNCT
gs-3799	200	12	dynamic	dynamic	ADJ
gs-3799	200	13	drug	drug	NOUN
gs-3799	200	14	delivery	delivery	NOUN
gs-3799	200	15	within	within	ADP
gs-3799	200	16	cpb	cpb	NOUN
gs-3799	200	17	circuits	circuit	NOUN
gs-3799	200	18	must	must	AUX
gs-3799	200	19	account	account	VERB
gs-3799	200	20	for	for	ADP
gs-3799	200	21	altered	alter	VERB
gs-3799	200	22	pharmacokinetics	pharmacokinetic	NOUN
gs-3799	200	23	and	and	CCONJ
gs-3799	200	24	pharmacodynamics	pharmacodynamic	NOUN
gs-3799	200	25	due	due	ADP
gs-3799	200	26	to	to	ADP
gs-3799	200	27	hemodilution	hemodilution	NOUN
gs-3799	200	28	,	,	PUNCT
gs-3799	200	29	non	non	ADJ
gs-3799	200	30	-	-	ADJ
gs-3799	200	31	pulsatile	pulsatile	ADJ
gs-3799	200	32	flow	flow	NOUN
gs-3799	200	33	,	,	PUNCT
gs-3799	200	34	hypothermia	hypothermia	NOUN
gs-3799	200	35	,	,	PUNCT
gs-3799	200	36	and	and	CCONJ
gs-3799	200	37	organ	organ	NOUN
gs-3799	200	38	hypoperfusion	hypoperfusion	NOUN
gs-3799	200	39	.	.	PUNCT
gs-3799	201	1	continuous	continuous	ADJ
gs-3799	201	2	infusion	infusion	NOUN
gs-3799	201	3	pumps	pump	NOUN
gs-3799	201	4	and	and	CCONJ
gs-3799	201	5	feedback	feedback	NOUN
gs-3799	201	6	-	-	PUNCT
gs-3799	201	7	controlled	control	VERB
gs-3799	201	8	syringe	syringe	NOUN
gs-3799	201	9	drivers	driver	NOUN
gs-3799	201	10	must	must	AUX
gs-3799	201	11	maintain	maintain	VERB
gs-3799	201	12	precise	precise	ADJ
gs-3799	201	13	dosing	dose	VERB
gs-3799	201	14	under	under	ADP
gs-3799	201	15	these	these	DET
gs-3799	201	16	altered	altered	ADJ
gs-3799	201	17	conditions	condition	NOUN
gs-3799	201	18	.	.	PUNCT
gs-3799	202	1	the	the	DET
gs-3799	202	2	development	development	NOUN
gs-3799	202	3	of	of	ADP
gs-3799	202	4	pharmacokinetic	pharmacokinetic	ADJ
gs-3799	202	5	models	model	NOUN
gs-3799	202	6	specific	specific	ADJ
gs-3799	202	7	to	to	ADP
gs-3799	202	8	cpb	cpb	NOUN
gs-3799	202	9	physiology	physiology	NOUN
gs-3799	202	10	is	be	AUX
gs-3799	202	11	ongoing	ongoing	ADJ
gs-3799	202	12	,	,	PUNCT
gs-3799	202	13	aiming	aim	VERB
gs-3799	202	14	to	to	PART
gs-3799	202	15	match	match	VERB
gs-3799	202	16	drug	drug	NOUN
gs-3799	202	17	behavior	behavior	NOUN
gs-3799	202	18	more	more	ADV
gs-3799	202	19	accurately	accurately	ADV
gs-3799	202	20	to	to	ADP
gs-3799	202	21	real	real	ADJ
gs-3799	202	22	-	-	PUNCT
gs-3799	202	23	time	time	NOUN
gs-3799	202	24	demands	demand	NOUN
gs-3799	202	25	.	.	PUNCT
gs-3799	203	1	anticoagulation	anticoagulation	NOUN
gs-3799	203	2	,	,	PUNCT
gs-3799	203	3	typically	typically	ADV
gs-3799	203	4	managed	manage	VERB
gs-3799	203	5	with	with	ADP
gs-3799	203	6	heparin	heparin	ADJ
gs-3799	203	7	and	and	CCONJ
gs-3799	203	8	protamine	protamine	NOUN
gs-3799	203	9	,	,	PUNCT
gs-3799	203	10	exemplifies	exemplify	VERB
gs-3799	203	11	the	the	DET
gs-3799	203	12	complexity	complexity	NOUN
gs-3799	203	13	of	of	ADP
gs-3799	203	14	this	this	DET
gs-3799	203	15	challenge	challenge	NOUN
gs-3799	203	16	.	.	PUNCT
gs-3799	204	1	automated	automate	VERB
gs-3799	204	2	titration	titration	NOUN
gs-3799	204	3	protocols	protocol	NOUN
gs-3799	204	4	based	base	VERB
gs-3799	204	5	on	on	ADP
gs-3799	204	6	activated	activate	VERB
gs-3799	204	7	clotting	clotting	NOUN
gs-3799	204	8	time	time	NOUN
gs-3799	204	9	or	or	CCONJ
gs-3799	204	10	viscoelastic	viscoelastic	ADJ
gs-3799	204	11	assays	assay	NOUN
gs-3799	204	12	are	be	AUX
gs-3799	204	13	under	under	ADP
gs-3799	204	14	evaluation	evaluation	NOUN
gs-3799	204	15	,	,	PUNCT
gs-3799	204	16	with	with	ADP
gs-3799	204	17	the	the	DET
gs-3799	204	18	goal	goal	NOUN
gs-3799	204	19	of	of	ADP
gs-3799	204	20	optimizing	optimize	VERB
gs-3799	204	21	anticoagulant	anticoagulant	NOUN
gs-3799	204	22	use	use	NOUN
gs-3799	204	23	while	while	SCONJ
gs-3799	204	24	minimizing	minimize	VERB
gs-3799	204	25	bleeding	bleeding	NOUN
gs-3799	204	26	and	and	CCONJ
gs-3799	204	27	thrombotic	thrombotic	ADJ
gs-3799	204	28	risks	risk	NOUN
gs-3799	204	29	.	.	PUNCT
gs-3799	205	1	ethical	ethical	ADJ
gs-3799	205	2	considerations	consideration	NOUN
gs-3799	205	3	also	also	ADV
gs-3799	205	4	emerge	emerge	VERB
gs-3799	205	5	with	with	ADP
gs-3799	205	6	the	the	DET
gs-3799	205	7	increased	increase	VERB
gs-3799	205	8	use	use	NOUN
gs-3799	205	9	of	of	ADP
gs-3799	205	10	automation	automation	NOUN
gs-3799	205	11	in	in	ADP
gs-3799	205	12	critical	critical	ADJ
gs-3799	205	13	care	care	NOUN
gs-3799	205	14	settings	setting	NOUN
gs-3799	205	15	.	.	PUNCT
gs-3799	206	1	the	the	DET
gs-3799	206	2	question	question	NOUN
gs-3799	206	3	of	of	ADP
gs-3799	206	4	liability	liability	NOUN
gs-3799	206	5	in	in	ADP
gs-3799	206	6	the	the	DET
gs-3799	206	7	event	event	NOUN
gs-3799	206	8	of	of	ADP
gs-3799	206	9	algorithm	algorithm	NOUN
gs-3799	206	10	failure	failure	NOUN
gs-3799	206	11	,	,	PUNCT
gs-3799	206	12	the	the	DET
gs-3799	206	13	patient	patient	NOUN
gs-3799	206	14	’s	’	VERB
gs-3799	206	15	right	right	NOUN
gs-3799	206	16	to	to	PART
gs-3799	206	17	understand	understand	VERB
gs-3799	206	18	and	and	CCONJ
gs-3799	206	19	consent	consent	VERB
gs-3799	206	20	to	to	ADP
gs-3799	206	21	automated	automate	VERB
gs-3799	206	22	decision	decision	NOUN
gs-3799	206	23	-	-	PUNCT
gs-3799	206	24	making	making	NOUN
gs-3799	206	25	,	,	PUNCT
gs-3799	206	26	and	and	CCONJ
gs-3799	206	27	the	the	DET
gs-3799	206	28	risk	risk	NOUN
gs-3799	206	29	of	of	ADP
gs-3799	206	30	over	over	ADP
gs-3799	206	31	-	-	PUNCT
gs-3799	206	32	reliance	reliance	NOUN
gs-3799	206	33	on	on	ADP
gs-3799	206	34	machine	machine	NOUN
gs-3799	206	35	-	-	PUNCT
gs-3799	206	36	generated	generate	VERB
gs-3799	206	37	outputs	output	NOUN
gs-3799	206	38	are	be	AUX
gs-3799	206	39	important	important	ADJ
gs-3799	206	40	topics	topic	NOUN
gs-3799	206	41	that	that	PRON
gs-3799	206	42	must	must	AUX
gs-3799	206	43	be	be	AUX
gs-3799	206	44	addressed	address	VERB
gs-3799	206	45	as	as	ADP
gs-3799	206	46	these	these	DET
gs-3799	206	47	systems	system	NOUN
gs-3799	206	48	progress	progress	VERB
gs-3799	206	49	from	from	ADP
gs-3799	206	50	research	research	NOUN
gs-3799	206	51	to	to	ADP
gs-3799	206	52	routine	routine	ADJ
gs-3799	206	53	practice	practice	NOUN
gs-3799	206	54	.	.	PUNCT
gs-3799	207	1	clinician	clinician	NOUN
gs-3799	207	2	trust	trust	NOUN
gs-3799	207	3	in	in	ADP
gs-3799	207	4	closed	closed	ADJ
gs-3799	207	5	-	-	PUNCT
gs-3799	207	6	loop	loop	NOUN
gs-3799	207	7	technology	technology	NOUN
gs-3799	207	8	is	be	AUX
gs-3799	207	9	closely	closely	ADV
gs-3799	207	10	tied	tie	VERB
gs-3799	207	11	to	to	ADP
gs-3799	207	12	the	the	DET
gs-3799	207	13	transparency	transparency	NOUN
gs-3799	207	14	,	,	PUNCT
gs-3799	207	15	predictability	predictability	NOUN
gs-3799	207	16	,	,	PUNCT
gs-3799	207	17	and	and	CCONJ
gs-3799	207	18	reproducibility	reproducibility	NOUN
gs-3799	207	19	of	of	ADP
gs-3799	207	20	system	system	NOUN
gs-3799	207	21	behavior	behavior	NOUN
gs-3799	207	22	under	under	ADP
gs-3799	207	23	variable	variable	ADJ
gs-3799	207	24	clinical	clinical	ADJ
gs-3799	207	25	scenarios	scenario	NOUN
gs-3799	207	26	.	.	PUNCT
gs-3799	208	1	in	in	ADP
gs-3799	208	2	parallel	parallel	NOUN
gs-3799	208	3	,	,	PUNCT
gs-3799	208	4	the	the	DET
gs-3799	208	5	potential	potential	NOUN
gs-3799	208	6	for	for	ADP
gs-3799	208	7	artificial	artificial	ADJ
gs-3799	208	8	intelligence	intelligence	NOUN
gs-3799	208	9	and	and	CCONJ
gs-3799	208	10	machine	machine	NOUN
gs-3799	208	11	learning	learn	VERB
gs-3799	208	12	to	to	PART
gs-3799	208	13	enhance	enhance	VERB
gs-3799	208	14	closed	close	VERB
gs-3799	208	15	-	-	PUNCT
gs-3799	208	16	loop	loop	NOUN
gs-3799	208	17	cpb	cpb	NOUN
gs-3799	208	18	is	be	AUX
gs-3799	208	19	rapidly	rapidly	ADV
gs-3799	208	20	growing	grow	VERB
gs-3799	208	21	.	.	PUNCT
gs-3799	209	1	these	these	DET
gs-3799	209	2	technologies	technology	NOUN
gs-3799	209	3	can	can	AUX
gs-3799	209	4	assimilate	assimilate	VERB
gs-3799	209	5	vast	vast	ADJ
gs-3799	209	6	quantities	quantity	NOUN
gs-3799	209	7	of	of	ADP
gs-3799	209	8	intraoperative	intraoperative	ADJ
gs-3799	209	9	and	and	CCONJ
gs-3799	209	10	preoperative	preoperative	ADJ
gs-3799	209	11	data	datum	NOUN
gs-3799	209	12	to	to	PART
gs-3799	209	13	forecast	forecast	VERB
gs-3799	209	14	patient	patient	ADJ
gs-3799	209	15	trajectories	trajectory	NOUN
gs-3799	209	16	,	,	PUNCT
gs-3799	209	17	identify	identify	VERB
gs-3799	209	18	patterns	pattern	NOUN
gs-3799	209	19	of	of	ADP
gs-3799	209	20	instability	instability	NOUN
gs-3799	209	21	,	,	PUNCT
gs-3799	209	22	and	and	CCONJ
gs-3799	209	23	suggest	suggest	VERB
gs-3799	209	24	preemptive	preemptive	ADJ
gs-3799	209	25	adjustments	adjustment	NOUN
gs-3799	209	26	.	.	PUNCT
gs-3799	210	1	ai	ai	VERB
gs-3799	210	2	-	-	PUNCT
gs-3799	210	3	enabled	enable	VERB
gs-3799	210	4	systems	system	NOUN
gs-3799	210	5	may	may	AUX
gs-3799	210	6	ultimately	ultimately	ADV
gs-3799	210	7	surpass	surpass	VERB
gs-3799	210	8	conventional	conventional	ADJ
gs-3799	210	9	algorithmic	algorithmic	ADJ
gs-3799	210	10	control	control	NOUN
gs-3799	210	11	in	in	ADP
gs-3799	210	12	recognizing	recognize	VERB
gs-3799	210	13	nuanced	nuanced	ADJ
gs-3799	210	14	physiologic	physiologic	ADJ
gs-3799	210	15	deviations	deviation	NOUN
gs-3799	210	16	and	and	CCONJ
gs-3799	210	17	predicting	predict	VERB
gs-3799	210	18	adverse	adverse	ADJ
gs-3799	210	19	outcomes	outcome	NOUN
gs-3799	210	20	.	.	PUNCT
gs-3799	211	1	however	however	ADV
gs-3799	211	2	,	,	PUNCT
gs-3799	211	3	this	this	PRON
gs-3799	211	4	introduces	introduce	VERB
gs-3799	211	5	further	further	ADJ
gs-3799	211	6	concerns	concern	NOUN
gs-3799	211	7	regarding	regard	VERB
gs-3799	211	8	data	datum	NOUN
gs-3799	211	9	security	security	NOUN
gs-3799	211	10	,	,	PUNCT
gs-3799	211	11	algorithmic	algorithmic	ADJ
gs-3799	211	12	bias	bias	NOUN
gs-3799	211	13	,	,	PUNCT
gs-3799	211	14	and	and	CCONJ
gs-3799	211	15	the	the	DET
gs-3799	211	16	explainability	explainability	NOUN
gs-3799	211	17	of	of	ADP
gs-3799	211	18	machine	machine	NOUN
gs-3799	211	19	decisions	decision	NOUN
gs-3799	211	20	.	.	PUNCT
gs-3799	212	1	the	the	DET
gs-3799	212	2	training	training	NOUN
gs-3799	212	3	of	of	ADP
gs-3799	212	4	clinical	clinical	ADJ
gs-3799	212	5	personnel	personnel	NOUN
gs-3799	212	6	to	to	PART
gs-3799	212	7	operate	operate	VERB
gs-3799	212	8	and	and	CCONJ
gs-3799	212	9	interpret	interpret	VERB
gs-3799	212	10	closed	closed	ADJ
gs-3799	212	11	-	-	PUNCT
gs-3799	212	12	loop	loop	NOUN
gs-3799	212	13	systems	system	NOUN
gs-3799	212	14	is	be	AUX
gs-3799	212	15	another	another	DET
gs-3799	212	16	pressing	press	VERB
gs-3799	212	17	requirement	requirement	NOUN
gs-3799	212	18	.	.	PUNCT
gs-3799	213	1	surgeons	surgeon	NOUN
gs-3799	213	2	,	,	PUNCT
gs-3799	213	3	perfusionists	perfusionist	NOUN
gs-3799	213	4	,	,	PUNCT
gs-3799	213	5	and	and	CCONJ
gs-3799	213	6	anesthesiologists	anesthesiologist	NOUN
gs-3799	213	7	must	must	AUX
gs-3799	213	8	become	become	VERB
gs-3799	213	9	familiar	familiar	ADJ
gs-3799	213	10	with	with	ADP
gs-3799	213	11	the	the	DET
gs-3799	213	12	principles	principle	NOUN
gs-3799	213	13	of	of	ADP
gs-3799	213	14	automated	automate	VERB
gs-3799	213	15	control	control	NOUN
gs-3799	213	16	,	,	PUNCT
gs-3799	213	17	system	system	NOUN
gs-3799	213	18	limitations	limitation	NOUN
gs-3799	213	19	,	,	PUNCT
gs-3799	213	20	and	and	CCONJ
gs-3799	213	21	potential	potential	ADJ
gs-3799	213	22	failure	failure	NOUN
gs-3799	213	23	modes	mode	NOUN
gs-3799	213	24	.	.	PUNCT
gs-3799	214	1	simulation	simulation	NOUN
gs-3799	214	2	-	-	PUNCT
gs-3799	214	3	based	base	VERB
gs-3799	214	4	training	training	NOUN
gs-3799	214	5	,	,	PUNCT
gs-3799	214	6	decision	decision	NOUN
gs-3799	214	7	-	-	PUNCT
gs-3799	214	8	support	support	NOUN
gs-3799	214	9	dashboards	dashboard	NOUN
gs-3799	214	10	,	,	PUNCT
gs-3799	214	11	and	and	CCONJ
gs-3799	214	12	modular	modular	ADJ
gs-3799	214	13	user	user	NOUN
gs-3799	214	14	interfaces	interface	NOUN
gs-3799	214	15	are	be	AUX
gs-3799	214	16	emerging	emerge	VERB
gs-3799	214	17	tools	tool	NOUN
gs-3799	214	18	to	to	PART
gs-3799	214	19	bridge	bridge	VERB
gs-3799	214	20	the	the	DET
gs-3799	214	21	gap	gap	NOUN
gs-3799	214	22	between	between	ADP
gs-3799	214	23	technological	technological	ADJ
gs-3799	214	24	complexity	complexity	NOUN
gs-3799	214	25	and	and	CCONJ
gs-3799	214	26	clinical	clinical	ADJ
gs-3799	214	27	usability	usability	NOUN
gs-3799	214	28	.	.	PUNCT
gs-3799	215	1	closed	close	VERB
gs-3799	215	2	-	-	PUNCT
gs-3799	215	3	loop	loop	NOUN
gs-3799	215	4	cpb	cpb	PROPN
gs-3799	215	5	systems	system	NOUN
gs-3799	215	6	have	have	VERB
gs-3799	215	7	the	the	DET
gs-3799	215	8	potential	potential	NOUN
gs-3799	215	9	to	to	PART
gs-3799	215	10	serve	serve	VERB
gs-3799	215	11	as	as	ADP
gs-3799	215	12	a	a	DET
gs-3799	215	13	platform	platform	NOUN
gs-3799	215	14	for	for	ADP
gs-3799	215	15	personalized	personalized	ADJ
gs-3799	215	16	extracorporeal	extracorporeal	NOUN
gs-3799	215	17	support	support	NOUN
gs-3799	215	18	tailored	tailor	VERB
gs-3799	215	19	to	to	ADP
gs-3799	215	20	genomic	genomic	NOUN
gs-3799	215	21	,	,	PUNCT
gs-3799	215	22	proteomic	proteomic	NOUN
gs-3799	215	23	,	,	PUNCT
gs-3799	215	24	and	and	CCONJ
gs-3799	215	25	metabolomic	metabolomic	ADJ
gs-3799	215	26	profiles	profile	NOUN
gs-3799	215	27	.	.	PUNCT
gs-3799	216	1	by	by	ADP
gs-3799	216	2	incorporating	incorporate	VERB
gs-3799	216	3	patient	patient	NOUN
gs-3799	216	4	-	-	PUNCT
gs-3799	216	5	specific	specific	ADJ
gs-3799	216	6	biomarkers	biomarker	NOUN
gs-3799	216	7	into	into	ADP
gs-3799	216	8	feedback	feedback	NOUN
gs-3799	216	9	loops	loop	NOUN
gs-3799	216	10	,	,	PUNCT
gs-3799	216	11	these	these	DET
gs-3799	216	12	systems	system	NOUN
gs-3799	216	13	could	could	AUX
gs-3799	216	14	refine	refine	VERB
gs-3799	216	15	therapeutic	therapeutic	ADJ
gs-3799	216	16	strategies	strategy	NOUN
gs-3799	216	17	to	to	ADP
gs-3799	216	18	an	an	DET
gs-3799	216	19	unprecedented	unprecedented	ADJ
gs-3799	216	20	level	level	NOUN
gs-3799	216	21	of	of	ADP
gs-3799	216	22	precision	precision	NOUN
gs-3799	216	23	.	.	PUNCT
gs-3799	217	1	research	research	NOUN
gs-3799	217	2	is	be	AUX
gs-3799	217	3	underway	underway	ADJ
gs-3799	217	4	to	to	PART
gs-3799	217	5	integrate	integrate	VERB
gs-3799	217	6	immune	immune	ADJ
gs-3799	217	7	response	response	NOUN
gs-3799	217	8	profiling	profiling	NOUN
gs-3799	217	9	,	,	PUNCT
gs-3799	217	10	coagulation	coagulation	NOUN
gs-3799	217	11	markers	marker	NOUN
gs-3799	217	12	,	,	PUNCT
gs-3799	217	13	and	and	CCONJ
gs-3799	217	14	endothelial	endothelial	ADJ
gs-3799	217	15	function	function	NOUN
gs-3799	217	16	assays	assay	NOUN
gs-3799	217	17	into	into	ADP
gs-3799	217	18	intraoperative	intraoperative	ADJ
gs-3799	217	19	monitoring	monitoring	NOUN
gs-3799	217	20	platforms	platform	NOUN
gs-3799	217	21	,	,	PUNCT
gs-3799	217	22	allowing	allow	VERB
gs-3799	217	23	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	217	24	and	and	CCONJ
gs-3799	217	25	perfusion	perfusion	NOUN
gs-3799	217	26	control	control	NOUN
gs-3799	217	27	to	to	PART
gs-3799	217	28	respond	respond	VERB
gs-3799	217	29	in	in	ADP
gs-3799	217	30	real	real	ADJ
gs-3799	217	31	time	time	NOUN
gs-3799	217	32	to	to	ADP
gs-3799	217	33	individual	individual	ADJ
gs-3799	217	34	biological	biological	ADJ
gs-3799	217	35	signatures	signature	NOUN
gs-3799	217	36	.	.	PUNCT
gs-3799	218	1	the	the	DET
gs-3799	218	2	convergence	convergence	NOUN
gs-3799	218	3	of	of	ADP
gs-3799	218	4	robotics	robotic	NOUN
gs-3799	218	5	,	,	PUNCT
gs-3799	218	6	real	real	ADJ
gs-3799	218	7	-	-	PUNCT
gs-3799	218	8	time	time	NOUN
gs-3799	218	9	analytics	analytic	NOUN
gs-3799	218	10	,	,	PUNCT
gs-3799	218	11	and	and	CCONJ
gs-3799	218	12	regenerative	regenerative	ADJ
gs-3799	218	13	medicine	medicine	NOUN
gs-3799	218	14	may	may	AUX
gs-3799	218	15	further	far	ADV
gs-3799	218	16	extend	extend	VERB
gs-3799	218	17	the	the	DET
gs-3799	218	18	application	application	NOUN
gs-3799	218	19	of	of	ADP
gs-3799	218	20	closed	closed	ADJ
gs-3799	218	21	-	-	PUNCT
gs-3799	218	22	loop	loop	NOUN
gs-3799	218	23	systems	system	NOUN
gs-3799	218	24	beyond	beyond	ADP
gs-3799	218	25	the	the	DET
gs-3799	218	26	operating	operating	NOUN
gs-3799	218	27	room	room	NOUN
gs-3799	218	28	into	into	ADP
gs-3799	218	29	intensive	intensive	ADJ
gs-3799	218	30	care	care	NOUN
gs-3799	218	31	,	,	PUNCT
gs-3799	218	32	cardiac	cardiac	ADJ
gs-3799	218	33	support	support	NOUN
gs-3799	218	34	,	,	PUNCT
gs-3799	218	35	and	and	CCONJ
gs-3799	218	36	even	even	ADV
gs-3799	218	37	remote	remote	ADJ
gs-3799	218	38	intervention	intervention	NOUN
gs-3799	218	39	contexts	contexts	NOUN
gs-3799	218	40	.	.	PUNCT
gs-3799	219	1	portable	portable	ADJ
gs-3799	219	2	systems	system	NOUN
gs-3799	219	3	capable	capable	ADJ
gs-3799	219	4	of	of	ADP
gs-3799	219	5	closed	closed	ADJ
gs-3799	219	6	-	-	PUNCT
gs-3799	219	7	loop	loop	NOUN
gs-3799	219	8	support	support	NOUN
gs-3799	219	9	in	in	ADP
gs-3799	219	10	field	field	NOUN
gs-3799	219	11	hospitals	hospital	NOUN
gs-3799	219	12	,	,	PUNCT
gs-3799	219	13	space	space	NOUN
gs-3799	219	14	exploration	exploration	NOUN
gs-3799	219	15	,	,	PUNCT
gs-3799	219	16	or	or	CCONJ
gs-3799	219	17	battlefield	battlefield	NOUN
gs-3799	219	18	environments	environment	NOUN
gs-3799	219	19	are	be	AUX
gs-3799	219	20	already	already	ADV
gs-3799	219	21	in	in	ADP
gs-3799	219	22	conceptual	conceptual	ADJ
gs-3799	219	23	development	development	NOUN
gs-3799	219	24	.	.	PUNCT
gs-3799	220	1	these	these	DET
gs-3799	220	2	future	future	ADJ
gs-3799	220	3	directions	direction	NOUN
gs-3799	220	4	underscore	underscore	VERB
gs-3799	220	5	the	the	DET
gs-3799	220	6	critical	critical	ADJ
gs-3799	220	7	importance	importance	NOUN
gs-3799	220	8	of	of	ADP
gs-3799	220	9	designing	design	VERB
gs-3799	220	10	modular	modular	ADJ
gs-3799	220	11	,	,	PUNCT
gs-3799	220	12	scalable	scalable	ADJ
gs-3799	220	13	,	,	PUNCT
gs-3799	220	14	and	and	CCONJ
gs-3799	220	15	adaptive	adaptive	ADJ
gs-3799	220	16	systems	system	NOUN
gs-3799	220	17	capable	capable	ADJ
gs-3799	220	18	of	of	ADP
gs-3799	220	19	functioning	function	VERB
gs-3799	220	20	in	in	ADP
gs-3799	220	21	diverse	diverse	ADJ
gs-3799	220	22	clinical	clinical	ADJ
gs-3799	220	23	and	and	CCONJ
gs-3799	220	24	logistical	logistical	ADJ
gs-3799	220	25	scenarios	scenario	NOUN
gs-3799	220	26	.	.	PUNCT
gs-3799	221	1	georgian	georgian	NOUN
gs-3799	221	2	scientists/	scientists/	NUM
gs-3799	221	3	.	.	PUNCT
gs-3799	222	1	7	7	NUM
gs-3799	222	2	n	n	PRON
gs-3799	222	3	2	2	NUM
gs-3799	222	4	,	,	PUNCT
gs-3799	222	5	2025	2025	NUM
gs-3799	222	6	392	392	NUM
gs-3799	222	7	as	as	SCONJ
gs-3799	222	8	the	the	DET
gs-3799	222	9	boundaries	boundary	NOUN
gs-3799	222	10	between	between	ADP
gs-3799	222	11	mechanical	mechanical	ADJ
gs-3799	222	12	support	support	NOUN
gs-3799	222	13	,	,	PUNCT
gs-3799	222	14	therapeutic	therapeutic	ADJ
gs-3799	222	15	modulation	modulation	NOUN
gs-3799	222	16	,	,	PUNCT
gs-3799	222	17	and	and	CCONJ
gs-3799	222	18	predictive	predictive	ADJ
gs-3799	222	19	diagnostics	diagnostic	NOUN
gs-3799	222	20	continue	continue	VERB
gs-3799	222	21	to	to	PART
gs-3799	222	22	blur	blur	VERB
gs-3799	222	23	,	,	PUNCT
gs-3799	222	24	the	the	DET
gs-3799	222	25	role	role	NOUN
gs-3799	222	26	of	of	ADP
gs-3799	222	27	closed	closed	ADJ
gs-3799	222	28	-	-	PUNCT
gs-3799	222	29	loop	loop	NOUN
gs-3799	222	30	cpb	cpb	NOUN
gs-3799	222	31	systems	system	NOUN
gs-3799	222	32	will	will	AUX
gs-3799	222	33	likely	likely	ADV
gs-3799	222	34	expand	expand	VERB
gs-3799	222	35	beyond	beyond	ADP
gs-3799	222	36	conventional	conventional	ADJ
gs-3799	222	37	definitions	definition	NOUN
gs-3799	222	38	.	.	PUNCT
gs-3799	223	1	they	they	PRON
gs-3799	223	2	represent	represent	VERB
gs-3799	223	3	not	not	PART
gs-3799	223	4	merely	merely	ADV
gs-3799	223	5	an	an	DET
gs-3799	223	6	evolution	evolution	NOUN
gs-3799	223	7	of	of	ADP
gs-3799	223	8	perfusion	perfusion	NOUN
gs-3799	223	9	technology	technology	NOUN
gs-3799	223	10	but	but	CCONJ
gs-3799	223	11	a	a	DET
gs-3799	223	12	transformation	transformation	NOUN
gs-3799	223	13	in	in	ADP
gs-3799	223	14	how	how	SCONJ
gs-3799	223	15	critical	critical	ADJ
gs-3799	223	16	physiological	physiological	ADJ
gs-3799	223	17	support	support	NOUN
gs-3799	223	18	is	be	AUX
gs-3799	223	19	conceptualized	conceptualize	VERB
gs-3799	223	20	,	,	PUNCT
gs-3799	223	21	implemented	implement	VERB
gs-3799	223	22	,	,	PUNCT
gs-3799	223	23	and	and	CCONJ
gs-3799	223	24	refined	refine	VERB
gs-3799	223	25	.	.	PUNCT
gs-3799	224	1	the	the	DET
gs-3799	224	2	transition	transition	NOUN
gs-3799	224	3	from	from	ADP
gs-3799	224	4	reactive	reactive	ADJ
gs-3799	224	5	to	to	ADP
gs-3799	224	6	predictive	predictive	ADJ
gs-3799	224	7	medicine	medicine	NOUN
gs-3799	224	8	,	,	PUNCT
gs-3799	224	9	and	and	CCONJ
gs-3799	224	10	from	from	ADP
gs-3799	224	11	manual	manual	ADJ
gs-3799	224	12	control	control	NOUN
gs-3799	224	13	to	to	ADP
gs-3799	224	14	intelligent	intelligent	ADJ
gs-3799	224	15	automation	automation	NOUN
gs-3799	224	16	,	,	PUNCT
gs-3799	224	17	signals	signal	VERB
gs-3799	224	18	a	a	DET
gs-3799	224	19	paradigm	paradigm	NOUN
gs-3799	224	20	shift	shift	NOUN
gs-3799	224	21	that	that	PRON
gs-3799	224	22	will	will	AUX
gs-3799	224	23	redefine	redefine	VERB
gs-3799	224	24	perioperative	perioperative	ADJ
gs-3799	224	25	care	care	NOUN
gs-3799	224	26	for	for	ADP
gs-3799	224	27	the	the	DET
gs-3799	224	28	next	next	ADJ
gs-3799	224	29	generation	generation	NOUN
gs-3799	224	30	.	.	PUNCT
gs-3799	225	1	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	225	2	bypass	bypass	NOUN
gs-3799	225	3	(	(	PUNCT
gs-3799	225	4	cpb	cpb	NOUN
gs-3799	225	5	)	)	PUNCT
gs-3799	225	6	serves	serve	VERB
gs-3799	225	7	as	as	ADP
gs-3799	225	8	an	an	DET
gs-3799	225	9	indispensable	indispensable	ADJ
gs-3799	225	10	technological	technological	ADJ
gs-3799	225	11	foundation	foundation	NOUN
gs-3799	225	12	for	for	ADP
gs-3799	225	13	openheart	openheart	PROPN
gs-3799	225	14	surgery	surgery	NOUN
gs-3799	225	15	,	,	PUNCT
gs-3799	225	16	temporarily	temporarily	ADV
gs-3799	225	17	assuming	assume	VERB
gs-3799	225	18	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	225	19	function	function	NOUN
gs-3799	225	20	to	to	PART
gs-3799	225	21	facilitate	facilitate	VERB
gs-3799	225	22	complex	complex	ADJ
gs-3799	225	23	cardiac	cardiac	ADJ
gs-3799	225	24	interventions	intervention	NOUN
gs-3799	225	25	.	.	PUNCT
gs-3799	226	1	despite	despite	SCONJ
gs-3799	226	2	its	its	PRON
gs-3799	226	3	life	life	NOUN
gs-3799	226	4	-	-	PUNCT
gs-3799	226	5	saving	save	VERB
gs-3799	226	6	role	role	NOUN
gs-3799	226	7	,	,	PUNCT
gs-3799	226	8	conventional	conventional	ADJ
gs-3799	226	9	cpb	cpb	PROPN
gs-3799	226	10	management	management	NOUN
gs-3799	226	11	operates	operate	VERB
gs-3799	226	12	predominantly	predominantly	ADV
gs-3799	226	13	as	as	ADP
gs-3799	226	14	an	an	DET
gs-3799	226	15	open	open	ADJ
gs-3799	226	16	-	-	PUNCT
gs-3799	226	17	loop	loop	NOUN
gs-3799	226	18	system	system	NOUN
gs-3799	226	19	,	,	PUNCT
gs-3799	226	20	demanding	demand	VERB
gs-3799	226	21	perpetual	perpetual	ADJ
gs-3799	226	22	manual	manual	ADJ
gs-3799	226	23	oversight	oversight	NOUN
gs-3799	226	24	by	by	ADP
gs-3799	226	25	perfusionists	perfusionist	NOUN
gs-3799	226	26	who	who	PRON
gs-3799	226	27	must	must	AUX
gs-3799	226	28	interpret	interpret	VERB
gs-3799	226	29	disparate	disparate	ADJ
gs-3799	226	30	physiological	physiological	ADJ
gs-3799	226	31	data	datum	NOUN
gs-3799	226	32	streams	stream	NOUN
gs-3799	226	33	and	and	CCONJ
gs-3799	226	34	reactively	reactively	ADV
gs-3799	226	35	adjust	adjust	VERB
gs-3799	226	36	pump	pump	NOUN
gs-3799	226	37	parameters	parameter	NOUN
gs-3799	226	38	,	,	PUNCT
gs-3799	226	39	gas	gas	NOUN
gs-3799	226	40	exchange	exchange	NOUN
gs-3799	226	41	,	,	PUNCT
gs-3799	226	42	temperature	temperature	NOUN
gs-3799	226	43	,	,	PUNCT
gs-3799	226	44	and	and	CCONJ
gs-3799	226	45	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	226	46	.	.	PUNCT
gs-3799	227	1	this	this	DET
gs-3799	227	2	labor	labor	NOUN
gs-3799	227	3	-	-	PUNCT
gs-3799	227	4	intensive	intensive	ADJ
gs-3799	227	5	process	process	NOUN
gs-3799	227	6	introduces	introduce	VERB
gs-3799	227	7	significant	significant	ADJ
gs-3799	227	8	risks	risk	NOUN
gs-3799	227	9	:	:	PUNCT
gs-3799	227	10	hemodynamic	hemodynamic	ADJ
gs-3799	227	11	instability	instability	NOUN
gs-3799	227	12	from	from	ADP
gs-3799	227	13	delayed	delay	VERB
gs-3799	227	14	responses	response	NOUN
gs-3799	227	15	to	to	ADP
gs-3799	227	16	fluctuating	fluctuate	VERB
gs-3799	227	17	blood	blood	NOUN
gs-3799	227	18	pressure	pressure	NOUN
gs-3799	227	19	or	or	CCONJ
gs-3799	227	20	flow	flow	NOUN
gs-3799	227	21	;	;	PUNCT
gs-3799	227	22	suboptimal	suboptimal	ADJ
gs-3799	227	23	anticoagulation	anticoagulation	NOUN
gs-3799	227	24	management	management	NOUN
gs-3799	227	25	leading	lead	VERB
gs-3799	227	26	to	to	ADP
gs-3799	227	27	thrombosis	thrombosis	NOUN
gs-3799	227	28	or	or	CCONJ
gs-3799	227	29	hemorrhage	hemorrhage	NOUN
gs-3799	227	30	;	;	PUNCT
gs-3799	227	31	unmodulated	unmodulated	ADJ
gs-3799	227	32	systemic	systemic	ADJ
gs-3799	227	33	inflammatory	inflammatory	ADJ
gs-3799	227	34	responses	response	NOUN
gs-3799	227	35	;	;	PUNCT
gs-3799	227	36	and	and	CCONJ
gs-3799	227	37	heightened	heighten	VERB
gs-3799	227	38	potential	potential	NOUN
gs-3799	227	39	for	for	ADP
gs-3799	227	40	end	end	NOUN
gs-3799	227	41	-	-	PUNCT
gs-3799	227	42	organ	organ	NOUN
gs-3799	227	43	injury	injury	NOUN
gs-3799	227	44	.	.	PUNCT
gs-3799	228	1	these	these	DET
gs-3799	228	2	challenges	challenge	NOUN
gs-3799	228	3	stem	stem	VERB
gs-3799	228	4	fundamentally	fundamentally	ADV
gs-3799	228	5	from	from	ADP
gs-3799	228	6	human	human	ADJ
gs-3799	228	7	cognitive	cognitive	ADJ
gs-3799	228	8	limitations	limitation	NOUN
gs-3799	228	9	in	in	ADP
gs-3799	228	10	high	high	ADJ
gs-3799	228	11	-	-	PUNCT
gs-3799	228	12	stress	stress	NOUN
gs-3799	228	13	environments	environment	NOUN
gs-3799	228	14	,	,	PUNCT
gs-3799	228	15	variability	variability	NOUN
gs-3799	228	16	in	in	ADP
gs-3799	228	17	practitioner	practitioner	NOUN
gs-3799	228	18	expertise	expertise	NOUN
gs-3799	228	19	,	,	PUNCT
gs-3799	228	20	and	and	CCONJ
gs-3799	228	21	the	the	DET
gs-3799	228	22	inherent	inherent	ADJ
gs-3799	228	23	latency	latency	NOUN
gs-3799	228	24	of	of	ADP
gs-3799	228	25	intermittent	intermittent	ADJ
gs-3799	228	26	monitoring	monitoring	NOUN
gs-3799	228	27	and	and	CCONJ
gs-3799	228	28	intervention	intervention	NOUN
gs-3799	228	29	protocols	protocol	NOUN
gs-3799	228	30	.	.	PUNCT
gs-3799	229	1	the	the	DET
gs-3799	229	2	pursuit	pursuit	NOUN
gs-3799	229	3	of	of	ADP
gs-3799	229	4	automation	automation	NOUN
gs-3799	229	5	to	to	PART
gs-3799	229	6	enhance	enhance	VERB
gs-3799	229	7	cpb	cpb	PROPN
gs-3799	229	8	safety	safety	NOUN
gs-3799	229	9	and	and	CCONJ
gs-3799	229	10	efficacy	efficacy	NOUN
gs-3799	229	11	has	have	AUX
gs-3799	229	12	evolved	evolve	VERB
gs-3799	229	13	substantially	substantially	ADV
gs-3799	229	14	,	,	PUNCT
gs-3799	229	15	driven	drive	VERB
gs-3799	229	16	by	by	ADP
gs-3799	229	17	advances	advance	NOUN
gs-3799	229	18	in	in	ADP
gs-3799	229	19	real	real	ADJ
gs-3799	229	20	-	-	PUNCT
gs-3799	229	21	time	time	NOUN
gs-3799	229	22	monitoring	monitoring	NOUN
gs-3799	229	23	technologies	technology	NOUN
gs-3799	229	24	.	.	PUNCT
gs-3799	230	1	continuous	continuous	ADJ
gs-3799	230	2	sensors	sensor	NOUN
gs-3799	230	3	now	now	ADV
gs-3799	230	4	enable	enable	VERB
gs-3799	230	5	dynamic	dynamic	ADJ
gs-3799	230	6	assessment	assessment	NOUN
gs-3799	230	7	of	of	ADP
gs-3799	230	8	critical	critical	ADJ
gs-3799	230	9	parameters	parameter	NOUN
gs-3799	230	10	—	—	PUNCT
gs-3799	230	11	including	include	VERB
gs-3799	230	12	blood	blood	NOUN
gs-3799	230	13	gases	gas	NOUN
gs-3799	230	14	(	(	PUNCT
gs-3799	230	15	po	po	INTJ
gs-3799	230	16	,	,	PUNCT
gs-3799	230	17	pco	pco	NOUN
gs-3799	230	18	,	,	PUNCT
gs-3799	230	19	ph	ph	NOUN
gs-3799	230	20	)	)	PUNCT
gs-3799	230	21	,	,	PUNCT
gs-3799	230	22	activated	activate	VERB
gs-3799	230	23	clotting	clotting	NOUN
gs-3799	230	24	time	time	NOUN
gs-3799	230	25	(	(	PUNCT
gs-3799	230	26	act	act	PROPN
gs-3799	230	27	)	)	PUNCT
gs-3799	230	28	,	,	PUNCT
gs-3799	230	29	heparin	heparin	ADJ
gs-3799	230	30	concentration	concentration	NOUN
gs-3799	230	31	,	,	PUNCT
gs-3799	230	32	pressure	pressure	NOUN
gs-3799	230	33	,	,	PUNCT
gs-3799	230	34	flow	flow	NOUN
gs-3799	230	35	,	,	PUNCT
gs-3799	230	36	hematocrit	hematocrit	ADJ
gs-3799	230	37	,	,	PUNCT
gs-3799	230	38	and	and	CCONJ
gs-3799	230	39	temperature	temperature	NOUN
gs-3799	230	40	—	—	PUNCT
gs-3799	230	41	providing	provide	VERB
gs-3799	230	42	a	a	DET
gs-3799	230	43	comprehensive	comprehensive	ADJ
gs-3799	230	44	,	,	PUNCT
gs-3799	230	45	second	second	ADJ
gs-3799	230	46	-	-	PUNCT
gs-3799	230	47	bysecond	bysecond	ADJ
gs-3799	230	48	physiological	physiological	ADJ
gs-3799	230	49	portrait	portrait	NOUN
gs-3799	230	50	.	.	PUNCT
gs-3799	231	1	this	this	DET
gs-3799	231	2	capability	capability	NOUN
gs-3799	231	3	has	have	AUX
gs-3799	231	4	catalyzed	catalyze	VERB
gs-3799	231	5	the	the	DET
gs-3799	231	6	development	development	NOUN
gs-3799	231	7	of	of	ADP
gs-3799	231	8	closed	closed	ADJ
gs-3799	231	9	-	-	PUNCT
gs-3799	231	10	loop	loop	NOUN
gs-3799	231	11	control	control	NOUN
gs-3799	231	12	systems	system	NOUN
gs-3799	231	13	,	,	PUNCT
gs-3799	231	14	which	which	PRON
gs-3799	231	15	utilize	utilize	VERB
gs-3799	231	16	intelligent	intelligent	ADJ
gs-3799	231	17	algorithms	algorithm	NOUN
gs-3799	231	18	to	to	PART
gs-3799	231	19	process	process	VERB
gs-3799	231	20	sensor	sensor	NOUN
gs-3799	231	21	data	datum	NOUN
gs-3799	231	22	and	and	CCONJ
gs-3799	231	23	autonomously	autonomously	ADV
gs-3799	231	24	adjust	adjust	VERB
gs-3799	231	25	cpb	cpb	NOUN
gs-3799	231	26	operations	operation	NOUN
gs-3799	231	27	(	(	PUNCT
gs-3799	231	28	e.g.	e.g.	ADV
gs-3799	231	29	,	,	PUNCT
gs-3799	231	30	pump	pump	VERB
gs-3799	231	31	speed	speed	NOUN
gs-3799	231	32	,	,	PUNCT
gs-3799	231	33	oxygenator	oxygenator	NOUN
gs-3799	231	34	gas	gas	NOUN
gs-3799	231	35	blend	blend	NOUN
gs-3799	231	36	)	)	PUNCT
gs-3799	231	37	while	while	SCONJ
gs-3799	231	38	integrating	integrate	VERB
gs-3799	231	39	targeted	target	VERB
gs-3799	231	40	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	231	41	delivery	delivery	NOUN
gs-3799	231	42	.	.	PUNCT
gs-3799	232	1	this	this	DET
gs-3799	232	2	paradigm	paradigm	NOUN
gs-3799	232	3	shift	shift	NOUN
gs-3799	232	4	from	from	ADP
gs-3799	232	5	human	human	NOUN
gs-3799	232	6	-	-	PUNCT
gs-3799	232	7	directed	direct	VERB
gs-3799	232	8	reactive	reactive	ADJ
gs-3799	232	9	management	management	NOUN
gs-3799	232	10	to	to	ADP
gs-3799	232	11	algorithm	algorithm	NOUN
gs-3799	232	12	-	-	PUNCT
gs-3799	232	13	driven	drive	VERB
gs-3799	232	14	proactive	proactive	ADJ
gs-3799	232	15	control	control	NOUN
gs-3799	232	16	promises	promise	VERB
gs-3799	232	17	greater	great	ADJ
gs-3799	232	18	precision	precision	NOUN
gs-3799	232	19	,	,	PUNCT
gs-3799	232	20	reduced	reduce	VERB
gs-3799	232	21	cognitive	cognitive	ADJ
gs-3799	232	22	burden	burden	NOUN
gs-3799	232	23	on	on	ADP
gs-3799	232	24	perfusionists	perfusionist	NOUN
gs-3799	232	25	,	,	PUNCT
gs-3799	232	26	minimized	minimized	ADJ
gs-3799	232	27	human	human	ADJ
gs-3799	232	28	error	error	NOUN
gs-3799	232	29	,	,	PUNCT
gs-3799	232	30	and	and	CCONJ
gs-3799	232	31	theoretically	theoretically	ADV
gs-3799	232	32	superior	superior	ADJ
gs-3799	232	33	patient	patient	ADJ
gs-3799	232	34	outcomes	outcome	NOUN
gs-3799	232	35	through	through	ADP
gs-3799	232	36	enhanced	enhanced	ADJ
gs-3799	232	37	physiological	physiological	ADJ
gs-3799	232	38	stability	stability	NOUN
gs-3799	232	39	.	.	PUNCT
gs-3799	233	1	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	233	2	integration	integration	NOUN
gs-3799	233	3	represents	represent	VERB
gs-3799	233	4	a	a	DET
gs-3799	233	5	cornerstone	cornerstone	NOUN
gs-3799	233	6	of	of	ADP
gs-3799	233	7	effective	effective	ADJ
gs-3799	233	8	closed	closed	ADJ
gs-3799	233	9	-	-	PUNCT
gs-3799	233	10	loop	loop	NOUN
gs-3799	233	11	cpb	cpb	NOUN
gs-3799	233	12	.	.	PUNCT
gs-3799	234	1	anticoagulation	anticoagulation	NOUN
gs-3799	234	2	management	management	NOUN
gs-3799	234	3	—	—	PUNCT
gs-3799	234	4	primarily	primarily	ADV
gs-3799	234	5	heparin	heparin	ADJ
gs-3799	234	6	and	and	CCONJ
gs-3799	234	7	protamine	protamine	NOUN
gs-3799	234	8	titration	titration	NOUN
gs-3799	234	9	guided	guide	VERB
gs-3799	234	10	by	by	ADP
gs-3799	234	11	real	real	ADJ
gs-3799	234	12	-	-	PUNCT
gs-3799	234	13	time	time	NOUN
gs-3799	234	14	act	act	NOUN
gs-3799	234	15	or	or	CCONJ
gs-3799	234	16	heparin	heparin	ADJ
gs-3799	234	17	concentration	concentration	NOUN
gs-3799	234	18	monitors	monitor	NOUN
gs-3799	234	19	—	—	PUNCT
gs-3799	234	20	is	be	AUX
gs-3799	234	21	the	the	DET
gs-3799	234	22	most	most	ADV
gs-3799	234	23	established	establish	VERB
gs-3799	234	24	application	application	NOUN
gs-3799	234	25	,	,	PUNCT
gs-3799	234	26	aiming	aim	VERB
gs-3799	234	27	to	to	PART
gs-3799	234	28	optimize	optimize	VERB
gs-3799	234	29	time	time	NOUN
gs-3799	234	30	-	-	PUNCT
gs-3799	234	31	intherapeutic	intherapeutic	ADJ
gs-3799	234	32	-	-	PUNCT
gs-3799	234	33	range	range	NOUN
gs-3799	234	34	(	(	PUNCT
gs-3799	234	35	ttr	ttr	NOUN
gs-3799	234	36	)	)	PUNCT
gs-3799	234	37	and	and	CCONJ
gs-3799	234	38	mitigate	mitigate	VERB
gs-3799	234	39	thrombotic	thrombotic	ADJ
gs-3799	234	40	or	or	CCONJ
gs-3799	234	41	hemorrhagic	hemorrhagic	ADJ
gs-3799	234	42	complications	complication	NOUN
gs-3799	234	43	.	.	PUNCT
gs-3799	235	1	emerging	emerge	VERB
gs-3799	235	2	strategies	strategy	NOUN
gs-3799	235	3	extend	extend	VERB
gs-3799	235	4	to	to	ADP
gs-3799	235	5	closed	close	VERB
gs-3799	235	6	-	-	PUNCT
gs-3799	235	7	loop	loop	NOUN
gs-3799	235	8	administration	administration	NOUN
gs-3799	235	9	of	of	ADP
gs-3799	235	10	vasoactive	vasoactive	ADJ
gs-3799	235	11	agents	agent	NOUN
gs-3799	235	12	(	(	PUNCT
gs-3799	235	13	e.g.	e.g.	ADV
gs-3799	235	14	,	,	PUNCT
gs-3799	235	15	norepinephrine	norepinephrine	NOUN
gs-3799	235	16	,	,	PUNCT
gs-3799	235	17	vasopressin	vasopressin	NOUN
gs-3799	235	18	)	)	PUNCT
gs-3799	235	19	for	for	ADP
gs-3799	235	20	hemodynamic	hemodynamic	ADJ
gs-3799	235	21	stabilization	stabilization	NOUN
gs-3799	235	22	,	,	PUNCT
gs-3799	235	23	anti	anti	ADJ
gs-3799	235	24	-	-	ADJ
gs-3799	235	25	inflammatory	inflammatory	ADJ
gs-3799	235	26	therapies	therapy	NOUN
gs-3799	235	27	,	,	PUNCT
gs-3799	235	28	and	and	CCONJ
gs-3799	235	29	volume	volume	NOUN
gs-3799	235	30	management	management	NOUN
gs-3799	235	31	,	,	PUNCT
gs-3799	235	32	enabling	enable	VERB
gs-3799	235	33	continuous	continuous	ADJ
gs-3799	235	34	,	,	PUNCT
gs-3799	235	35	personalized	personalized	ADJ
gs-3799	235	36	dosing	dose	VERB
gs-3799	235	37	calibrated	calibrate	VERB
gs-3799	235	38	to	to	PART
gs-3799	235	39	immediate	immediate	ADJ
gs-3799	235	40	patient	patient	NOUN
gs-3799	235	41	needs	need	NOUN
gs-3799	235	42	.	.	PUNCT
gs-3799	236	1	this	this	DET
gs-3799	236	2	integration	integration	NOUN
gs-3799	236	3	addresses	address	VERB
gs-3799	236	4	critical	critical	ADJ
gs-3799	236	5	limitations	limitation	NOUN
gs-3799	236	6	of	of	ADP
gs-3799	236	7	manual	manual	ADJ
gs-3799	236	8	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	236	9	,	,	PUNCT
gs-3799	236	10	which	which	PRON
gs-3799	236	11	often	often	ADV
gs-3799	236	12	relies	rely	VERB
gs-3799	236	13	on	on	ADP
gs-3799	236	14	fixed	fix	VERB
gs-3799	236	15	protocols	protocol	NOUN
gs-3799	236	16	or	or	CCONJ
gs-3799	236	17	intermittent	intermittent	ADJ
gs-3799	236	18	assessments	assessment	NOUN
gs-3799	236	19	ill	ill	ADV
gs-3799	236	20	-	-	PUNCT
gs-3799	236	21	suited	suited	ADJ
gs-3799	236	22	to	to	ADP
gs-3799	236	23	the	the	DET
gs-3799	236	24	dynamic	dynamic	ADJ
gs-3799	236	25	cpb	cpb	PROPN
gs-3799	236	26	environment	environment	PROPN
gs-3799	236	27	.	.	PUNCT
gs-3799	237	1	contemporary	contemporary	ADJ
gs-3799	237	2	closed	close	VERB
gs-3799	237	3	-	-	PUNCT
gs-3799	237	4	loop	loop	NOUN
gs-3799	237	5	systems	system	NOUN
gs-3799	237	6	embody	embody	VERB
gs-3799	237	7	a	a	DET
gs-3799	237	8	convergence	convergence	NOUN
gs-3799	237	9	of	of	ADP
gs-3799	237	10	innovations	innovation	NOUN
gs-3799	237	11	:	:	PUNCT
gs-3799	237	12	sophisticated	sophisticated	ADJ
gs-3799	237	13	control	control	NOUN
gs-3799	237	14	algorithms	algorithm	NOUN
gs-3799	237	15	progressing	progress	VERB
gs-3799	237	16	beyond	beyond	ADP
gs-3799	237	17	proportional	proportional	ADJ
gs-3799	237	18	-	-	PUNCT
gs-3799	237	19	integral	integral	ADJ
gs-3799	237	20	-	-	PUNCT
gs-3799	237	21	derivative	derivative	ADJ
gs-3799	237	22	(	(	PUNCT
gs-3799	237	23	pid	pid	NOUN
gs-3799	237	24	)	)	PUNCT
gs-3799	237	25	logic	logic	NOUN
gs-3799	237	26	to	to	PART
gs-3799	237	27	incorporate	incorporate	VERB
gs-3799	237	28	fuzzy	fuzzy	ADJ
gs-3799	237	29	control	control	NOUN
gs-3799	237	30	,	,	PUNCT
gs-3799	237	31	model	model	ADJ
gs-3799	237	32	-	-	PUNCT
gs-3799	237	33	predictive	predictive	ADJ
gs-3799	237	34	control	control	NOUN
gs-3799	237	35	(	(	PUNCT
gs-3799	237	36	mpc	mpc	NOUN
gs-3799	237	37	)	)	PUNCT
gs-3799	237	38	,	,	PUNCT
gs-3799	237	39	and	and	CCONJ
gs-3799	237	40	artificial	artificial	ADJ
gs-3799	237	41	intelligence	intelligence	NOUN
gs-3799	237	42	/	/	SYM
gs-3799	237	43	machine	machine	NOUN
gs-3799	237	44	learning	learning	NOUN
gs-3799	237	45	(	(	PUNCT
gs-3799	237	46	ai	ai	VERB
gs-3799	237	47	/	/	SYM
gs-3799	237	48	ml	ml	NOUN
gs-3799	237	49	)	)	PUNCT
gs-3799	237	50	for	for	ADP
gs-3799	237	51	adaptive	adaptive	ADJ
gs-3799	237	52	,	,	PUNCT
gs-3799	237	53	predictive	predictive	ADJ
gs-3799	237	54	,	,	PUNCT
gs-3799	237	55	and	and	CCONJ
gs-3799	237	56	personalized	personalized	ADJ
gs-3799	237	57	management	management	NOUN
gs-3799	237	58	;	;	PUNCT
gs-3799	237	59	robust	robust	ADJ
gs-3799	237	60	multi	multi	ADJ
gs-3799	237	61	-	-	ADJ
gs-3799	237	62	parameter	parameter	ADJ
gs-3799	237	63	sensor	sensor	NOUN
gs-3799	237	64	fusion	fusion	NOUN
gs-3799	237	65	enhancing	enhance	VERB
gs-3799	237	66	system	system	NOUN
gs-3799	237	67	reliability	reliability	NOUN
gs-3799	237	68	;	;	PUNCT
gs-3799	237	69	intuitive	intuitive	ADJ
gs-3799	237	70	human	human	ADJ
gs-3799	237	71	-	-	PUNCT
gs-3799	237	72	machine	machine	NOUN
gs-3799	237	73	interfaces	interface	NOUN
gs-3799	237	74	(	(	PUNCT
gs-3799	237	75	hmis	hmis	ADV
gs-3799	237	76	)	)	PUNCT
gs-3799	237	77	maintaining	maintain	VERB
gs-3799	237	78	situational	situational	ADJ
gs-3799	237	79	awareness	awareness	NOUN
gs-3799	237	80	while	while	SCONJ
gs-3799	237	81	georgian	georgian	PROPN
gs-3799	237	82	scientists/	scientists/	NUM
gs-3799	237	83	.	.	PUNCT
gs-3799	238	1	7	7	NUM
gs-3799	238	2	n	n	DET
gs-3799	238	3	2	2	NUM
gs-3799	238	4	,	,	PUNCT
gs-3799	238	5	2025	2025	NUM
gs-3799	238	6	393	393	NUM
gs-3799	238	7	clarifying	clarify	VERB
gs-3799	238	8	automation	automation	NOUN
gs-3799	238	9	levels	level	NOUN
gs-3799	238	10	;	;	PUNCT
gs-3799	238	11	and	and	CCONJ
gs-3799	238	12	redundant	redundant	ADJ
gs-3799	238	13	safety	safety	NOUN
gs-3799	238	14	architectures	architecture	NOUN
gs-3799	238	15	ensuring	ensure	VERB
gs-3799	238	16	fail	fail	ADJ
gs-3799	238	17	-	-	PUNCT
gs-3799	238	18	safe	safe	ADJ
gs-3799	238	19	operation	operation	NOUN
gs-3799	238	20	.	.	PUNCT
gs-3799	239	1	despite	despite	SCONJ
gs-3799	239	2	this	this	DET
gs-3799	239	3	technological	technological	ADJ
gs-3799	239	4	momentum	momentum	NOUN
gs-3799	239	5	,	,	PUNCT
gs-3799	239	6	the	the	DET
gs-3799	239	7	evidence	evidence	NOUN
gs-3799	239	8	base	base	NOUN
gs-3799	239	9	remains	remain	VERB
gs-3799	239	10	fragmented	fragmented	ADJ
gs-3799	239	11	.	.	PUNCT
gs-3799	240	1	studies	study	NOUN
gs-3799	240	2	often	often	ADV
gs-3799	240	3	focus	focus	VERB
gs-3799	240	4	narrowly	narrowly	ADV
gs-3799	240	5	on	on	ADP
gs-3799	240	6	isolated	isolated	ADJ
gs-3799	240	7	components	component	NOUN
gs-3799	240	8	—	—	PUNCT
gs-3799	240	9	particularly	particularly	ADV
gs-3799	240	10	anticoagulation	anticoagulation	NOUN
gs-3799	240	11	—	—	PUNCT
gs-3799	240	12	or	or	CCONJ
gs-3799	240	13	single	single	ADJ
gs-3799	240	14	proprietary	proprietary	ADJ
gs-3799	240	15	systems	system	NOUN
gs-3799	240	16	,	,	PUNCT
gs-3799	240	17	lacking	lack	VERB
gs-3799	240	18	comprehensive	comprehensive	ADJ
gs-3799	240	19	analysis	analysis	NOUN
gs-3799	240	20	of	of	ADP
gs-3799	240	21	integrated	integrate	VERB
gs-3799	240	22	closed	closed	ADJ
gs-3799	240	23	-	-	PUNCT
gs-3799	240	24	loop	loop	NOUN
gs-3799	240	25	architectures	architecture	NOUN
gs-3799	240	26	combining	combine	VERB
gs-3799	240	27	real	real	ADJ
gs-3799	240	28	-	-	PUNCT
gs-3799	240	29	time	time	NOUN
gs-3799	240	30	monitoring	monitoring	NOUN
gs-3799	240	31	with	with	ADP
gs-3799	240	32	multi	multi	ADJ
gs-3799	240	33	-	-	ADJ
gs-3799	240	34	modal	modal	ADJ
gs-3799	240	35	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	240	36	.	.	PUNCT
gs-3799	241	1	robust	robust	ADJ
gs-3799	241	2	comparative	comparative	ADJ
gs-3799	241	3	data	datum	NOUN
gs-3799	241	4	on	on	ADP
gs-3799	241	5	clinical	clinical	ADJ
gs-3799	241	6	outcomes	outcome	NOUN
gs-3799	241	7	(	(	PUNCT
gs-3799	241	8	e.g.	e.g.	ADV
gs-3799	241	9	,	,	PUNCT
gs-3799	241	10	mortality	mortality	NOUN
gs-3799	241	11	,	,	PUNCT
gs-3799	241	12	stroke	stroke	NOUN
gs-3799	241	13	,	,	PUNCT
gs-3799	241	14	renal	renal	ADJ
gs-3799	241	15	injury	injury	NOUN
gs-3799	241	16	,	,	PUNCT
gs-3799	241	17	transfusion	transfusion	NOUN
gs-3799	241	18	needs	need	NOUN
gs-3799	241	19	)	)	PUNCT
gs-3799	241	20	and	and	CCONJ
gs-3799	241	21	operational	operational	ADJ
gs-3799	241	22	impacts	impact	NOUN
gs-3799	241	23	(	(	PUNCT
gs-3799	241	24	workflow	workflow	NOUN
gs-3799	241	25	efficiency	efficiency	NOUN
gs-3799	241	26	,	,	PUNCT
gs-3799	241	27	resource	resource	NOUN
gs-3799	241	28	utilization	utilization	NOUN
gs-3799	241	29	,	,	PUNCT
gs-3799	241	30	human	human	ADJ
gs-3799	241	31	factors	factor	NOUN
gs-3799	241	32	)	)	PUNCT
gs-3799	241	33	versus	versus	ADP
gs-3799	241	34	conventional	conventional	ADJ
gs-3799	241	35	cpb	cpb	NOUN
gs-3799	241	36	is	be	AUX
gs-3799	241	37	scarce	scarce	ADJ
gs-3799	241	38	,	,	PUNCT
gs-3799	241	39	especially	especially	ADV
gs-3799	241	40	from	from	ADP
gs-3799	241	41	large	large	ADJ
gs-3799	241	42	-	-	PUNCT
gs-3799	241	43	scale	scale	NOUN
gs-3799	241	44	randomized	randomized	ADJ
gs-3799	241	45	trials	trial	NOUN
gs-3799	241	46	.	.	PUNCT
gs-3799	242	1	furthermore	furthermore	ADV
gs-3799	242	2	,	,	PUNCT
gs-3799	242	3	systematic	systematic	ADJ
gs-3799	242	4	evaluation	evaluation	NOUN
gs-3799	242	5	of	of	ADP
gs-3799	242	6	how	how	SCONJ
gs-3799	242	7	specific	specific	ADJ
gs-3799	242	8	innovations	innovation	NOUN
gs-3799	242	9	translate	translate	VERB
gs-3799	242	10	to	to	ADP
gs-3799	242	11	real	real	ADJ
gs-3799	242	12	-	-	PUNCT
gs-3799	242	13	world	world	NOUN
gs-3799	242	14	performance	performance	NOUN
gs-3799	242	15	,	,	PUNCT
gs-3799	242	16	reliability	reliability	NOUN
gs-3799	242	17	,	,	PUNCT
gs-3799	242	18	and	and	CCONJ
gs-3799	242	19	safety	safety	NOUN
gs-3799	242	20	is	be	AUX
gs-3799	242	21	underdeveloped	underdeveloped	ADJ
gs-3799	242	22	,	,	PUNCT
gs-3799	242	23	while	while	SCONJ
gs-3799	242	24	implementation	implementation	NOUN
gs-3799	242	25	challenges	challenge	NOUN
gs-3799	242	26	—	—	PUNCT
gs-3799	242	27	including	include	VERB
gs-3799	242	28	perfusionist	perfusionist	NOUN
gs-3799	242	29	role	role	NOUN
gs-3799	242	30	evolution	evolution	NOUN
gs-3799	242	31	,	,	PUNCT
gs-3799	242	32	training	training	NOUN
gs-3799	242	33	paradigms	paradigm	NOUN
gs-3799	242	34	,	,	PUNCT
gs-3799	242	35	cost	cost	NOUN
gs-3799	242	36	-	-	PUNCT
gs-3799	242	37	effectiveness	effectiveness	NOUN
gs-3799	242	38	,	,	PUNCT
gs-3799	242	39	and	and	CCONJ
gs-3799	242	40	regulatory	regulatory	ADJ
gs-3799	242	41	pathways	pathway	NOUN
gs-3799	242	42	—	—	PUNCT
gs-3799	242	43	require	require	VERB
gs-3799	242	44	deeper	deep	ADJ
gs-3799	242	45	exploration	exploration	NOUN
gs-3799	242	46	.	.	PUNCT
gs-3799	243	1	a	a	DET
gs-3799	243	2	consolidated	consolidated	ADJ
gs-3799	243	3	,	,	PUNCT
gs-3799	243	4	forward	forward	ADV
gs-3799	243	5	-	-	PUNCT
gs-3799	243	6	looking	look	VERB
gs-3799	243	7	roadmap	roadmap	NOUN
gs-3799	243	8	prioritizing	prioritize	VERB
gs-3799	243	9	research	research	NOUN
gs-3799	243	10	and	and	CCONJ
gs-3799	243	11	development	development	NOUN
gs-3799	243	12	is	be	AUX
gs-3799	243	13	absent	absent	ADJ
gs-3799	243	14	.	.	PUNCT
gs-3799	244	1	goal	goal	NOUN
gs-3799	244	2	to	to	PART
gs-3799	244	3	comprehensively	comprehensively	ADV
gs-3799	244	4	characterize	characterize	VERB
gs-3799	244	5	the	the	DET
gs-3799	244	6	technological	technological	ADJ
gs-3799	244	7	features	feature	NOUN
gs-3799	244	8	,	,	PUNCT
gs-3799	244	9	architectures	architecture	NOUN
gs-3799	244	10	,	,	PUNCT
gs-3799	244	11	and	and	CCONJ
gs-3799	244	12	real	real	ADJ
gs-3799	244	13	-	-	PUNCT
gs-3799	244	14	time	time	NOUN
gs-3799	244	15	monitoring	monitoring	NOUN
gs-3799	244	16	capabilities	capability	NOUN
gs-3799	244	17	of	of	ADP
gs-3799	244	18	current	current	ADJ
gs-3799	244	19	closed	close	VERB
gs-3799	244	20	-	-	PUNCT
gs-3799	244	21	loop	loop	NOUN
gs-3799	244	22	cpb	cpb	PROPN
gs-3799	244	23	systems	system	NOUN
gs-3799	244	24	,	,	PUNCT
gs-3799	244	25	identifying	identify	VERB
gs-3799	244	26	key	key	ADJ
gs-3799	244	27	innovations	innovation	NOUN
gs-3799	244	28	in	in	ADP
gs-3799	244	29	automation	automation	NOUN
gs-3799	244	30	,	,	PUNCT
gs-3799	244	31	sensor	sensor	NOUN
gs-3799	244	32	integration	integration	NOUN
gs-3799	244	33	,	,	PUNCT
gs-3799	244	34	data	datum	NOUN
gs-3799	244	35	processing	processing	NOUN
gs-3799	244	36	,	,	PUNCT
gs-3799	244	37	and	and	CCONJ
gs-3799	244	38	control	control	NOUN
gs-3799	244	39	algorithms	algorithm	NOUN
gs-3799	244	40	.	.	PUNCT
gs-3799	245	1	focus	focus	NOUN
gs-3799	245	2	:	:	PUNCT
gs-3799	245	3	system	system	NOUN
gs-3799	245	4	design	design	NOUN
gs-3799	245	5	&	&	CCONJ
gs-3799	245	6	monitoring	monitor	VERB
gs-3799	245	7	innovation	innovation	NOUN
gs-3799	245	8	.	.	PUNCT
gs-3799	246	1	to	to	PART
gs-3799	246	2	evaluate	evaluate	VERB
gs-3799	246	3	the	the	DET
gs-3799	246	4	integration	integration	NOUN
gs-3799	246	5	strategies	strategy	NOUN
gs-3799	246	6	,	,	PUNCT
gs-3799	246	7	efficacy	efficacy	NOUN
gs-3799	246	8	,	,	PUNCT
gs-3799	246	9	and	and	CCONJ
gs-3799	246	10	safety	safety	NOUN
gs-3799	246	11	profiles	profile	NOUN
gs-3799	246	12	of	of	ADP
gs-3799	246	13	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	246	14	treatment	treatment	NOUN
gs-3799	246	15	protocols	protocol	NOUN
gs-3799	246	16	(	(	PUNCT
gs-3799	246	17	e.g.	e.g.	ADV
gs-3799	246	18	,	,	PUNCT
gs-3799	246	19	anticoagulation	anticoagulation	NOUN
gs-3799	246	20	management	management	NOUN
gs-3799	246	21	,	,	PUNCT
gs-3799	246	22	vasoactive	vasoactive	ADJ
gs-3799	246	23	drug	drug	NOUN
gs-3799	246	24	delivery	delivery	NOUN
gs-3799	246	25	,	,	PUNCT
gs-3799	246	26	anti	anti	ADJ
gs-3799	246	27	-	-	ADJ
gs-3799	246	28	inflammatory	inflammatory	ADJ
gs-3799	246	29	agents	agent	NOUN
gs-3799	246	30	)	)	PUNCT
gs-3799	246	31	within	within	ADP
gs-3799	246	32	closed	closed	ADJ
gs-3799	246	33	-	-	PUNCT
gs-3799	246	34	loop	loop	NOUN
gs-3799	246	35	cpb	cpb	NOUN
gs-3799	246	36	systems	system	NOUN
gs-3799	246	37	utilizing	utilize	VERB
gs-3799	246	38	real	real	ADJ
gs-3799	246	39	-	-	PUNCT
gs-3799	246	40	time	time	NOUN
gs-3799	246	41	physiological	physiological	ADJ
gs-3799	246	42	and	and	CCONJ
gs-3799	246	43	biochemical	biochemical	ADJ
gs-3799	246	44	feedback	feedback	NOUN
gs-3799	246	45	.	.	PUNCT
gs-3799	247	1	focus	focus	NOUN
gs-3799	247	2	:	:	PUNCT
gs-3799	247	3	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	247	4	integration	integration	NOUN
gs-3799	247	5	&	&	CCONJ
gs-3799	247	6	performance	performance	NOUN
gs-3799	247	7	.	.	PUNCT
gs-3799	248	1	to	to	PART
gs-3799	248	2	systematically	systematically	ADV
gs-3799	248	3	assess	assess	VERB
gs-3799	248	4	the	the	DET
gs-3799	248	5	clinical	clinical	ADJ
gs-3799	248	6	and	and	CCONJ
gs-3799	248	7	operational	operational	ADJ
gs-3799	248	8	outcomes	outcome	NOUN
gs-3799	248	9	associated	associate	VERB
gs-3799	248	10	with	with	ADP
gs-3799	248	11	closed	closed	ADJ
gs-3799	248	12	-	-	PUNCT
gs-3799	248	13	loop	loop	NOUN
gs-3799	248	14	cpb	cpb	NOUN
gs-3799	248	15	systems	system	NOUN
gs-3799	248	16	compared	compare	VERB
gs-3799	248	17	to	to	ADP
gs-3799	248	18	conventional	conventional	ADJ
gs-3799	248	19	manual	manual	ADJ
gs-3799	248	20	cpb	cpb	NOUN
gs-3799	248	21	management	management	NOUN
gs-3799	248	22	,	,	PUNCT
gs-3799	248	23	focusing	focus	VERB
gs-3799	248	24	on	on	ADP
gs-3799	248	25	hemodynamic	hemodynamic	ADJ
gs-3799	248	26	stability	stability	NOUN
gs-3799	248	27	,	,	PUNCT
gs-3799	248	28	organ	organ	NOUN
gs-3799	248	29	protection	protection	NOUN
gs-3799	248	30	,	,	PUNCT
gs-3799	248	31	incidence	incidence	NOUN
gs-3799	248	32	of	of	ADP
gs-3799	248	33	complications	complication	NOUN
gs-3799	248	34	(	(	PUNCT
gs-3799	248	35	e.g.	e.g.	ADV
gs-3799	248	36	,	,	PUNCT
gs-3799	248	37	bleeding	bleeding	NOUN
gs-3799	248	38	,	,	PUNCT
gs-3799	248	39	thrombosis	thrombosis	NOUN
gs-3799	248	40	,	,	PUNCT
gs-3799	248	41	inflammation	inflammation	NOUN
gs-3799	248	42	)	)	PUNCT
gs-3799	248	43	,	,	PUNCT
gs-3799	248	44	procedure	procedure	NOUN
gs-3799	248	45	time	time	NOUN
gs-3799	248	46	,	,	PUNCT
gs-3799	248	47	resource	resource	NOUN
gs-3799	248	48	utilization	utilization	NOUN
gs-3799	248	49	,	,	PUNCT
gs-3799	248	50	and	and	CCONJ
gs-3799	248	51	overall	overall	ADJ
gs-3799	248	52	patient	patient	ADJ
gs-3799	248	53	safety	safety	NOUN
gs-3799	248	54	.	.	PUNCT
gs-3799	249	1	focus	focus	NOUN
gs-3799	249	2	:	:	PUNCT
gs-3799	250	1	comparative	comparative	ADJ
gs-3799	250	2	outcomes	outcome	NOUN
gs-3799	250	3	(	(	PUNCT
gs-3799	250	4	clinical	clinical	ADJ
gs-3799	250	5	&	&	CCONJ
gs-3799	250	6	operational	operational	ADJ
gs-3799	250	7	)	)	PUNCT
gs-3799	250	8	.	.	PUNCT
gs-3799	251	1	to	to	PART
gs-3799	251	2	identify	identify	VERB
gs-3799	251	3	and	and	CCONJ
gs-3799	251	4	analyze	analyze	VERB
gs-3799	251	5	the	the	DET
gs-3799	251	6	most	most	ADV
gs-3799	251	7	significant	significant	ADJ
gs-3799	251	8	innovations	innovation	NOUN
gs-3799	251	9	and	and	CCONJ
gs-3799	251	10	their	their	PRON
gs-3799	251	11	impact	impact	NOUN
gs-3799	251	12	on	on	ADP
gs-3799	251	13	system	system	NOUN
gs-3799	251	14	reliability	reliability	NOUN
gs-3799	251	15	,	,	PUNCT
gs-3799	251	16	user	user	NOUN
gs-3799	251	17	interaction	interaction	NOUN
gs-3799	251	18	(	(	PUNCT
gs-3799	251	19	perfusionist	perfusionist	NOUN
gs-3799	251	20	role	role	NOUN
gs-3799	251	21	)	)	PUNCT
gs-3799	251	22	,	,	PUNCT
gs-3799	251	23	adaptability	adaptability	NOUN
gs-3799	251	24	to	to	ADP
gs-3799	251	25	complex	complex	ADJ
gs-3799	251	26	clinical	clinical	ADJ
gs-3799	251	27	scenarios	scenario	NOUN
gs-3799	251	28	,	,	PUNCT
gs-3799	251	29	and	and	CCONJ
gs-3799	251	30	potential	potential	ADJ
gs-3799	251	31	for	for	ADP
gs-3799	251	32	reducing	reduce	VERB
gs-3799	251	33	human	human	ADJ
gs-3799	251	34	error	error	NOUN
gs-3799	251	35	during	during	ADP
gs-3799	251	36	cpb	cpb	PROPN
gs-3799	251	37	.	.	PUNCT
gs-3799	251	38	focus	focus	PROPN
gs-3799	251	39	:	:	PUNCT
gs-3799	251	40	innovation	innovation	NOUN
gs-3799	251	41	impact	impact	NOUN
gs-3799	251	42	&	&	CCONJ
gs-3799	251	43	human	human	ADJ
gs-3799	251	44	factors	factor	NOUN
gs-3799	251	45	.	.	PUNCT
gs-3799	252	1	to	to	PART
gs-3799	252	2	synthesize	synthesize	VERB
gs-3799	252	3	findings	finding	NOUN
gs-3799	252	4	and	and	CCONJ
gs-3799	252	5	propose	propose	VERB
gs-3799	252	6	future	future	ADJ
gs-3799	252	7	research	research	NOUN
gs-3799	252	8	directions	direction	NOUN
gs-3799	252	9	and	and	CCONJ
gs-3799	252	10	development	development	NOUN
gs-3799	252	11	priorities	priority	NOUN
gs-3799	252	12	for	for	ADP
gs-3799	252	13	advancing	advance	VERB
gs-3799	252	14	closed	closed	ADJ
gs-3799	252	15	-	-	PUNCT
gs-3799	252	16	loop	loop	NOUN
gs-3799	252	17	cpb	cpb	PROPN
gs-3799	252	18	technology	technology	NOUN
gs-3799	252	19	,	,	PUNCT
gs-3799	252	20	including	include	VERB
gs-3799	252	21	enhancing	enhance	VERB
gs-3799	252	22	ai	ai	NOUN
gs-3799	252	23	/	/	SYM
gs-3799	252	24	ml	ml	NOUN
gs-3799	252	25	integration	integration	NOUN
gs-3799	252	26	,	,	PUNCT
gs-3799	252	27	personalizing	personalize	VERB
gs-3799	252	28	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	252	29	algorithms	algorithm	NOUN
gs-3799	252	30	,	,	PUNCT
gs-3799	252	31	improving	improve	VERB
gs-3799	252	32	sensor	sensor	NOUN
gs-3799	252	33	robustness	robustness	NOUN
gs-3799	252	34	,	,	PUNCT
gs-3799	252	35	addressing	address	VERB
gs-3799	252	36	regulatory	regulatory	ADJ
gs-3799	252	37	pathways	pathway	NOUN
gs-3799	252	38	,	,	PUNCT
gs-3799	252	39	and	and	CCONJ
gs-3799	252	40	defining	define	VERB
gs-3799	252	41	optimal	optimal	ADJ
gs-3799	252	42	implementation	implementation	NOUN
gs-3799	252	43	strategies	strategy	NOUN
gs-3799	252	44	.	.	PUNCT
gs-3799	253	1	focus	focus	NOUN
gs-3799	253	2	:	:	PUNCT
gs-3799	253	3	future	future	ADJ
gs-3799	253	4	directions	direction	NOUN
gs-3799	253	5	&	&	CCONJ
gs-3799	253	6	roadmap	roadmap	PROPN
gs-3799	253	7	.	.	PUNCT
gs-3799	254	1	methodology	methodology	NOUN
gs-3799	254	2	this	this	DET
gs-3799	254	3	study	study	NOUN
gs-3799	254	4	is	be	AUX
gs-3799	254	5	formatted	format	VERB
gs-3799	254	6	as	as	ADP
gs-3799	254	7	a	a	DET
gs-3799	254	8	narrative	narrative	NOUN
gs-3799	254	9	review	review	NOUN
gs-3799	254	10	of	of	ADP
gs-3799	254	11	current	current	ADJ
gs-3799	254	12	literature	literature	NOUN
gs-3799	254	13	on	on	ADP
gs-3799	254	14	closed	closed	ADJ
gs-3799	254	15	-	-	PUNCT
gs-3799	254	16	loop	loop	NOUN
gs-3799	254	17	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	254	18	bypass	bypass	NOUN
gs-3799	254	19	(	(	PUNCT
gs-3799	254	20	cpb	cpb	NOUN
gs-3799	254	21	)	)	PUNCT
gs-3799	254	22	systems	system	NOUN
gs-3799	254	23	in	in	ADP
gs-3799	254	24	pediatric	pediatric	ADJ
gs-3799	254	25	cardiac	cardiac	ADJ
gs-3799	254	26	surgery	surgery	NOUN
gs-3799	254	27	.	.	PUNCT
gs-3799	255	1	it	it	PRON
gs-3799	255	2	aims	aim	VERB
gs-3799	255	3	to	to	PART
gs-3799	255	4	focus	focus	VERB
gs-3799	255	5	on	on	ADP
gs-3799	255	6	automation	automation	NOUN
gs-3799	255	7	technologies	technology	NOUN
gs-3799	255	8	,	,	PUNCT
gs-3799	255	9	instantaneous	instantaneous	ADJ
gs-3799	255	10	monitoring	monitoring	NOUN
gs-3799	255	11	modalities	modality	NOUN
gs-3799	255	12	and	and	CCONJ
gs-3799	255	13	how	how	SCONJ
gs-3799	255	14	this	this	DET
gs-3799	255	15	system	system	NOUN
gs-3799	255	16	has	have	AUX
gs-3799	255	17	been	be	AUX
gs-3799	255	18	clinically	clinically	ADV
gs-3799	255	19	incorporated	incorporate	VERB
gs-3799	255	20	into	into	ADP
gs-3799	255	21	surgical	surgical	ADJ
gs-3799	255	22	workflows	workflow	NOUN
gs-3799	255	23	.	.	PUNCT
gs-3799	256	1	an	an	DET
gs-3799	256	2	extensive	extensive	ADJ
gs-3799	256	3	literature	literature	NOUN
gs-3799	256	4	search	search	NOUN
gs-3799	256	5	was	be	AUX
gs-3799	256	6	carried	carry	VERB
gs-3799	256	7	out	out	ADP
gs-3799	256	8	using	use	VERB
gs-3799	256	9	electronic	electronic	ADJ
gs-3799	256	10	georgian	georgian	NOUN
gs-3799	256	11	scientists/	scientists/	NUM
gs-3799	256	12	.	.	PUNCT
gs-3799	257	1	7	7	NUM
gs-3799	257	2	n	n	PRON
gs-3799	257	3	2	2	NUM
gs-3799	257	4	,	,	PUNCT
gs-3799	257	5	2025	2025	NUM
gs-3799	257	6	394	394	NUM
gs-3799	257	7	databases	database	NOUN
gs-3799	257	8	such	such	ADJ
gs-3799	257	9	as	as	ADP
gs-3799	257	10	pubmed	pubmed	PROPN
gs-3799	257	11	,	,	PUNCT
gs-3799	257	12	google	google	PROPN
gs-3799	257	13	scholar	scholar	NOUN
gs-3799	257	14	,	,	PUNCT
gs-3799	257	15	ieee	ieee	NOUN
gs-3799	257	16	xplore	xplore	PROPN
gs-3799	257	17	,	,	PUNCT
gs-3799	257	18	and	and	CCONJ
gs-3799	257	19	sciencedirect	sciencedirect	NOUN
gs-3799	257	20	,	,	PUNCT
gs-3799	257	21	to	to	PART
gs-3799	257	22	which	which	PRON
gs-3799	257	23	publications	publication	NOUN
gs-3799	257	24	from	from	ADP
gs-3799	257	25	january	january	PROPN
gs-3799	257	26	2000	2000	NUM
gs-3799	257	27	to	to	PART
gs-3799	257	28	may	may	AUX
gs-3799	257	29	2025	2025	NUM
gs-3799	257	30	were	be	AUX
gs-3799	257	31	referred	refer	VERB
gs-3799	257	32	.	.	PUNCT
gs-3799	258	1	the	the	DET
gs-3799	258	2	following	follow	VERB
gs-3799	258	3	keywords	keyword	NOUN
gs-3799	258	4	used	use	VERB
gs-3799	258	5	enhance	enhance	VERB
gs-3799	258	6	the	the	DET
gs-3799	258	7	search	search	NOUN
gs-3799	258	8	included	include	VERB
gs-3799	258	9	,	,	PUNCT
gs-3799	258	10	“	"	PUNCT
gs-3799	258	11	closed	closed	ADJ
gs-3799	258	12	-	-	PUNCT
gs-3799	258	13	loop	loop	NOUN
gs-3799	258	14	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	258	15	bypass	bypass	NOUN
gs-3799	258	16	”	"	PUNCT
gs-3799	258	17	and	and	CCONJ
gs-3799	258	18	pediatric	pediatric	ADJ
gs-3799	258	19	;	;	PUNCT
gs-3799	258	20	“	"	PUNCT
gs-3799	258	21	automated	automate	VERB
gs-3799	258	22	perfusion	perfusion	NOUN
gs-3799	258	23	control	control	NOUN
gs-3799	258	24	”	"	PUNCT
gs-3799	258	25	and	and	CCONJ
gs-3799	258	26	“	"	PUNCT
gs-3799	258	27	cardiac	cardiac	ADJ
gs-3799	258	28	surgery	surgery	NOUN
gs-3799	258	29	”	"	PUNCT
gs-3799	258	30	;	;	PUNCT
gs-3799	258	31	“	"	PUNCT
gs-3799	258	32	real	real	ADJ
gs-3799	258	33	-	-	PUNCT
gs-3799	258	34	time	time	NOUN
gs-3799	258	35	monitoring	monitoring	NOUN
gs-3799	258	36	”	"	PUNCT
gs-3799	258	37	and	and	CCONJ
gs-3799	258	38	“	"	PUNCT
gs-3799	258	39	pediatric	pediatric	ADJ
gs-3799	258	40	cpb	cpb	NOUN
gs-3799	258	41	”	"	PUNCT
gs-3799	258	42	;	;	PUNCT
gs-3799	258	43	“	"	PUNCT
gs-3799	258	44	near	near	ADV
gs-3799	258	45	-	-	PUNCT
gs-3799	258	46	infrared	infrared	ADJ
gs-3799	258	47	spectroscopy	spectroscopy	NOUN
gs-3799	258	48	”	"	PUNCT
gs-3799	258	49	and	and	CCONJ
gs-3799	258	50	“	"	PUNCT
gs-3799	258	51	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	258	52	bypass	bypass	NOUN
gs-3799	258	53	”	"	PUNCT
gs-3799	258	54	;	;	PUNCT
gs-3799	258	55	“	"	PUNCT
gs-3799	258	56	automation	automation	NOUN
gs-3799	258	57	in	in	ADP
gs-3799	258	58	extracorporeal	extracorporeal	NOUN
gs-3799	258	59	circulation	circulation	NOUN
gs-3799	258	60	”	"	PUNCT
gs-3799	258	61	and	and	CCONJ
gs-3799	258	62	neonate	neonate	NOUN
gs-3799	258	63	.	.	PUNCT
gs-3799	259	1	the	the	DET
gs-3799	259	2	search	search	NOUN
gs-3799	259	3	criteria	criterion	NOUN
gs-3799	259	4	were	be	AUX
gs-3799	259	5	inclusive	inclusive	ADJ
gs-3799	259	6	of	of	ADP
gs-3799	259	7	peer	peer	NOUN
gs-3799	259	8	-	-	PUNCT
gs-3799	259	9	reviewed	review	VERB
gs-3799	259	10	articles	article	NOUN
gs-3799	259	11	,	,	PUNCT
gs-3799	259	12	conference	conference	NOUN
gs-3799	259	13	proceedings	proceeding	NOUN
gs-3799	259	14	,	,	PUNCT
gs-3799	259	15	technical	technical	ADJ
gs-3799	259	16	white	white	ADJ
gs-3799	259	17	papers	paper	NOUN
gs-3799	259	18	,	,	PUNCT
gs-3799	259	19	studies	study	NOUN
gs-3799	259	20	focusing	focus	VERB
gs-3799	259	21	on	on	ADP
gs-3799	259	22	pediatric	pediatric	ADJ
gs-3799	259	23	or	or	CCONJ
gs-3799	259	24	neonatal	neonatal	ADJ
gs-3799	259	25	populations	population	NOUN
gs-3799	259	26	,	,	PUNCT
gs-3799	259	27	research	research	NOUN
gs-3799	259	28	involving	involve	VERB
gs-3799	259	29	closed	close	VERB
gs-3799	259	30	-	-	PUNCT
gs-3799	259	31	loop	loop	NOUN
gs-3799	259	32	or	or	CCONJ
gs-3799	259	33	automated	automate	VERB
gs-3799	259	34	cpb	cpb	NOUN
gs-3799	259	35	systems	system	NOUN
gs-3799	259	36	,	,	PUNCT
gs-3799	259	37	and	and	CCONJ
gs-3799	259	38	articles	article	NOUN
gs-3799	259	39	discussing	discuss	VERB
gs-3799	259	40	real	real	ADJ
gs-3799	259	41	-	-	PUNCT
gs-3799	259	42	time	time	NOUN
gs-3799	259	43	monitoring	monitoring	NOUN
gs-3799	259	44	technologies	technology	NOUN
gs-3799	259	45	in	in	ADP
gs-3799	259	46	cpb	cpb	PROPN
gs-3799	259	47	.	.	PUNCT
gs-3799	260	1	we	we	PRON
gs-3799	260	2	excluded	exclude	VERB
gs-3799	260	3	studies	study	NOUN
gs-3799	260	4	focusing	focus	VERB
gs-3799	260	5	solely	solely	ADV
gs-3799	260	6	on	on	ADP
gs-3799	260	7	adult	adult	NOUN
gs-3799	260	8	populations	population	NOUN
gs-3799	260	9	without	without	ADP
gs-3799	260	10	pediatric	pediatric	ADJ
gs-3799	260	11	relevance	relevance	NOUN
gs-3799	260	12	,	,	PUNCT
gs-3799	260	13	articles	article	NOUN
gs-3799	260	14	lacking	lack	VERB
gs-3799	260	15	methodological	methodological	ADJ
gs-3799	260	16	rigor	rigor	NOUN
gs-3799	260	17	or	or	CCONJ
gs-3799	260	18	sufficient	sufficient	ADJ
gs-3799	260	19	data	datum	NOUN
gs-3799	260	20	and	and	CCONJ
gs-3799	260	21	non	non	ADJ
gs-3799	260	22	-	-	ADJ
gs-3799	260	23	english	english	ADJ
gs-3799	260	24	publications	publication	NOUN
gs-3799	260	25	.	.	PUNCT
gs-3799	261	1	approximately	approximately	ADV
gs-3799	261	2	120	120	NUM
gs-3799	261	3	studies	study	NOUN
gs-3799	261	4	were	be	AUX
gs-3799	261	5	produced	produce	VERB
gs-3799	261	6	,	,	PUNCT
gs-3799	261	7	and	and	CCONJ
gs-3799	261	8	after	after	ADP
gs-3799	261	9	filtering	filter	VERB
gs-3799	261	10	through	through	ADP
gs-3799	261	11	the	the	DET
gs-3799	261	12	duplicated	duplicate	VERB
gs-3799	261	13	and	and	CCONJ
gs-3799	261	14	relevant	relevant	ADJ
gs-3799	261	15	abstracts	abstract	NOUN
gs-3799	261	16	,	,	PUNCT
gs-3799	261	17	76	76	NUM
gs-3799	261	18	articles	article	NOUN
gs-3799	261	19	met	meet	VERB
gs-3799	261	20	the	the	DET
gs-3799	261	21	requirements	requirement	NOUN
gs-3799	261	22	.	.	PUNCT
gs-3799	262	1	complete	complete	ADJ
gs-3799	262	2	reviews	review	NOUN
gs-3799	262	3	were	be	AUX
gs-3799	262	4	conducted	conduct	VERB
gs-3799	262	5	to	to	PART
gs-3799	262	6	obtain	obtain	VERB
gs-3799	262	7	data	datum	NOUN
gs-3799	262	8	on	on	ADP
gs-3799	262	9	the	the	DET
gs-3799	262	10	types	type	NOUN
gs-3799	262	11	of	of	ADP
gs-3799	262	12	automation	automation	NOUN
gs-3799	262	13	technologies	technology	NOUN
gs-3799	262	14	used	use	VERB
gs-3799	262	15	in	in	ADP
gs-3799	262	16	cpb	cpb	NOUN
gs-3799	262	17	,	,	PUNCT
gs-3799	262	18	procedures	procedure	NOUN
gs-3799	262	19	that	that	PRON
gs-3799	262	20	have	have	AUX
gs-3799	262	21	implemented	implement	VERB
gs-3799	262	22	real	real	ADJ
gs-3799	262	23	-	-	PUNCT
gs-3799	262	24	time	time	NOUN
gs-3799	262	25	monitoring	monitoring	NOUN
gs-3799	262	26	,	,	PUNCT
gs-3799	262	27	outcomes	outcome	NOUN
gs-3799	262	28	related	relate	VERB
gs-3799	262	29	to	to	ADP
gs-3799	262	30	hemodynamic	hemodynamic	ADJ
gs-3799	262	31	stability	stability	NOUN
gs-3799	262	32	and	and	CCONJ
gs-3799	262	33	patient	patient	ADJ
gs-3799	262	34	safety	safety	NOUN
gs-3799	262	35	,	,	PUNCT
gs-3799	262	36	and	and	CCONJ
gs-3799	262	37	obstacles	obstacle	NOUN
gs-3799	262	38	faced	face	VERB
gs-3799	262	39	with	with	ADP
gs-3799	262	40	integration	integration	NOUN
gs-3799	262	41	into	into	ADP
gs-3799	262	42	existing	exist	VERB
gs-3799	262	43	surgical	surgical	ADJ
gs-3799	262	44	workflows	workflow	NOUN
gs-3799	262	45	.	.	PUNCT
gs-3799	263	1	the	the	DET
gs-3799	263	2	following	follow	VERB
gs-3799	263	3	are	be	AUX
gs-3799	263	4	key	key	ADJ
gs-3799	263	5	findings	finding	NOUN
gs-3799	263	6	obtained	obtain	VERB
gs-3799	263	7	from	from	ADP
gs-3799	263	8	selected	select	VERB
gs-3799	263	9	studies	study	NOUN
gs-3799	263	10	.	.	PUNCT
gs-3799	264	1	in	in	ADP
gs-3799	264	2	regards	regard	NOUN
gs-3799	264	3	to	to	ADP
gs-3799	264	4	real	real	ADJ
gs-3799	264	5	-	-	PUNCT
gs-3799	264	6	time	time	NOUN
gs-3799	264	7	monitoring	monitoring	NOUN
gs-3799	264	8	technologies	technology	NOUN
gs-3799	264	9	,	,	PUNCT
gs-3799	264	10	near	near	ADV
gs-3799	264	11	-	-	PUNCT
gs-3799	264	12	infrared	infrared	ADJ
gs-3799	264	13	spectroscopy	spectroscopy	NOUN
gs-3799	264	14	(	(	PUNCT
gs-3799	264	15	nirs	nirs	PROPN
gs-3799	264	16	)	)	PUNCT
gs-3799	264	17	has	have	AUX
gs-3799	264	18	assisted	assist	VERB
gs-3799	264	19	with	with	ADP
gs-3799	264	20	the	the	DET
gs-3799	264	21	detection	detection	NOUN
gs-3799	264	22	of	of	ADP
gs-3799	264	23	cerebral	cerebral	ADJ
gs-3799	264	24	hypoxia	hypoxia	NOUN
gs-3799	264	25	during	during	ADP
gs-3799	264	26	pediatric	pediatric	ADJ
gs-3799	264	27	cpb	cpb	NOUN
gs-3799	264	28	by	by	ADP
gs-3799	264	29	carrying	carry	VERB
gs-3799	264	30	out	out	ADP
gs-3799	264	31	continuous	continuous	ADJ
gs-3799	264	32	cerebral	cerebral	ADJ
gs-3799	264	33	oxygenation	oxygenation	NOUN
gs-3799	264	34	monitoring	monitoring	NOUN
gs-3799	264	35	.	.	PUNCT
gs-3799	265	1	continuous	continuous	ADJ
gs-3799	265	2	mixed	mixed	ADJ
gs-3799	265	3	venous	venous	ADJ
gs-3799	265	4	oxygen	oxygen	NOUN
gs-3799	265	5	saturation	saturation	NOUN
gs-3799	265	6	(	(	PUNCT
gs-3799	265	7	svo	svo	NOUN
gs-3799	265	8	)	)	PUNCT
gs-3799	265	9	was	be	AUX
gs-3799	265	10	utilised	utilise	VERB
gs-3799	265	11	to	to	PART
gs-3799	265	12	guide	guide	VERB
gs-3799	265	13	goal	goal	NOUN
gs-3799	265	14	-	-	PUNCT
gs-3799	265	15	directed	direct	VERB
gs-3799	265	16	therapy	therapy	NOUN
gs-3799	265	17	,	,	PUNCT
gs-3799	265	18	therefore	therefore	ADV
gs-3799	265	19	enhancing	enhance	VERB
gs-3799	265	20	oxygen	oxygen	NOUN
gs-3799	265	21	delivery	delivery	NOUN
gs-3799	265	22	during	during	ADP
gs-3799	265	23	surgery	surgery	NOUN
gs-3799	265	24	.	.	PUNCT
gs-3799	266	1	a	a	DET
gs-3799	266	2	better	well	ADJ
gs-3799	266	3	comprehension	comprehension	NOUN
gs-3799	266	4	of	of	ADP
gs-3799	266	5	cerebrovascular	cerebrovascular	ADJ
gs-3799	266	6	hemodynamics	hemodynamic	NOUN
gs-3799	266	7	was	be	AUX
gs-3799	266	8	determined	determine	VERB
gs-3799	266	9	using	use	VERB
gs-3799	266	10	transfontanellar	transfontanellar	ADJ
gs-3799	266	11	doppler	doppler	NOUN
gs-3799	266	12	ultrasound	ultrasound	NOUN
gs-3799	266	13	which	which	PRON
gs-3799	266	14	validated	validate	VERB
gs-3799	266	15	the	the	DET
gs-3799	266	16	feasibility	feasibility	NOUN
gs-3799	266	17	of	of	ADP
gs-3799	266	18	monitoring	monitor	VERB
gs-3799	266	19	cerebral	cerebral	ADJ
gs-3799	266	20	blood	blood	NOUN
gs-3799	266	21	flow	flow	NOUN
gs-3799	266	22	dynamics	dynamic	NOUN
gs-3799	266	23	in	in	ADP
gs-3799	266	24	infants	infant	NOUN
gs-3799	266	25	.	.	PUNCT
gs-3799	267	1	concerning	concern	VERB
gs-3799	267	2	automation	automation	NOUN
gs-3799	267	3	in	in	ADP
gs-3799	267	4	cpb	cpb	PROPN
gs-3799	267	5	systems	systems	PROPN
gs-3799	267	6	,	,	PUNCT
gs-3799	267	7	controlled	control	VERB
gs-3799	267	8	automated	automate	VERB
gs-3799	267	9	reperfusion	reperfusion	NOUN
gs-3799	267	10	of	of	ADP
gs-3799	267	11	the	the	DET
gs-3799	267	12	whole	whole	ADJ
gs-3799	267	13	body	body	NOUN
gs-3799	267	14	(	(	PUNCT
gs-3799	267	15	carl	carl	PROPN
gs-3799	267	16	)	)	PUNCT
gs-3799	267	17	is	be	AUX
gs-3799	267	18	a	a	DET
gs-3799	267	19	technique	technique	NOUN
gs-3799	267	20	that	that	PRON
gs-3799	267	21	regulates	regulate	VERB
gs-3799	267	22	numerous	numerous	ADJ
gs-3799	267	23	blood	blood	NOUN
gs-3799	267	24	parameters	parameter	NOUN
gs-3799	267	25	to	to	PART
gs-3799	267	26	reduce	reduce	VERB
gs-3799	267	27	reperfusion	reperfusion	NOUN
gs-3799	267	28	injury	injury	NOUN
gs-3799	267	29	,	,	PUNCT
gs-3799	267	30	demonstrating	demonstrate	VERB
gs-3799	267	31	the	the	DET
gs-3799	267	32	prospects	prospect	NOUN
gs-3799	267	33	of	of	ADP
gs-3799	267	34	automation	automation	NOUN
gs-3799	267	35	in	in	ADP
gs-3799	267	36	improving	improve	VERB
gs-3799	267	37	patient	patient	ADJ
gs-3799	267	38	outcomes	outcome	NOUN
gs-3799	267	39	.	.	PUNCT
gs-3799	268	1	robot	robot	NOUN
gs-3799	268	2	-	-	PUNCT
gs-3799	268	3	assisted	assist	VERB
gs-3799	268	4	perfusion	perfusion	NOUN
gs-3799	268	5	systems	system	NOUN
gs-3799	268	6	(	(	PUNCT
gs-3799	268	7	raps	rap	NOUN
gs-3799	268	8	)	)	PUNCT
gs-3799	268	9	,	,	PUNCT
gs-3799	268	10	was	be	AUX
gs-3799	268	11	introduced	introduce	VERB
gs-3799	268	12	to	to	PART
gs-3799	268	13	enhance	enhance	VERB
gs-3799	268	14	patient	patient	ADJ
gs-3799	268	15	safety	safety	NOUN
gs-3799	268	16	by	by	ADP
gs-3799	268	17	incorporating	incorporate	VERB
gs-3799	268	18	automation	automation	NOUN
gs-3799	268	19	into	into	ADP
gs-3799	268	20	the	the	DET
gs-3799	268	21	cardiac	cardiac	ADJ
gs-3799	268	22	surgery	surgery	NOUN
gs-3799	268	23	workflow	workflow	NOUN
gs-3799	268	24	,	,	PUNCT
gs-3799	268	25	representing	represent	VERB
gs-3799	268	26	a	a	DET
gs-3799	268	27	non	non	ADJ
gs-3799	268	28	-	-	ADJ
gs-3799	268	29	human	human	ADJ
gs-3799	268	30	colleague	colleague	NOUN
gs-3799	268	31	.	.	PUNCT
gs-3799	269	1	standards	standard	NOUN
gs-3799	269	2	and	and	CCONJ
gs-3799	269	3	guidelines	guideline	NOUN
gs-3799	269	4	included	include	VERB
gs-3799	269	5	in	in	ADP
gs-3799	269	6	the	the	DET
gs-3799	269	7	research	research	NOUN
gs-3799	269	8	consist	consist	NOUN
gs-3799	269	9	of	of	ADP
gs-3799	269	10	the	the	DET
gs-3799	269	11	american	american	ADJ
gs-3799	269	12	society	society	NOUN
gs-3799	269	13	of	of	ADP
gs-3799	269	14	extracorporeal	extracorporeal	NOUN
gs-3799	269	15	technology	technology	NOUN
gs-3799	269	16	(	(	PUNCT
gs-3799	269	17	amsect	amsect	ADJ
gs-3799	269	18	)	)	PUNCT
gs-3799	269	19	,	,	PUNCT
gs-3799	269	20	yielding	yield	VERB
gs-3799	269	21	comprehensive	comprehensive	ADJ
gs-3799	269	22	standards	standard	NOUN
gs-3799	269	23	for	for	ADP
gs-3799	269	24	pediatric	pediatric	ADJ
gs-3799	269	25	and	and	CCONJ
gs-3799	269	26	congenital	congenital	ADJ
gs-3799	269	27	perfusion	perfusion	NOUN
gs-3799	269	28	practices	practice	NOUN
gs-3799	269	29	,	,	PUNCT
gs-3799	269	30	and	and	CCONJ
gs-3799	269	31	highlighting	highlight	VERB
gs-3799	269	32	continuous	continuous	ADJ
gs-3799	269	33	monitoring	monitoring	NOUN
gs-3799	269	34	of	of	ADP
gs-3799	269	35	arterial	arterial	ADJ
gs-3799	269	36	pressure	pressure	NOUN
gs-3799	269	37	,	,	PUNCT
gs-3799	269	38	blood	blood	NOUN
gs-3799	269	39	flow	flow	NOUN
gs-3799	269	40	,	,	PUNCT
gs-3799	269	41	and	and	CCONJ
gs-3799	269	42	oxygen	oxygen	NOUN
gs-3799	269	43	saturation	saturation	NOUN
gs-3799	269	44	during	during	ADP
gs-3799	269	45	cpb	cpb	NOUN
gs-3799	269	46	procedures	procedure	NOUN
gs-3799	269	47	.	.	PUNCT
gs-3799	270	1	in	in	ADP
gs-3799	270	2	addition	addition	NOUN
gs-3799	270	3	,	,	PUNCT
gs-3799	270	4	we	we	PRON
gs-3799	270	5	have	have	VERB
gs-3799	270	6	to	to	PART
gs-3799	270	7	acknowledge	acknowledge	VERB
gs-3799	270	8	the	the	DET
gs-3799	270	9	ethical	ethical	ADJ
gs-3799	270	10	concerns	concern	NOUN
gs-3799	270	11	about	about	ADP
gs-3799	270	12	the	the	DET
gs-3799	270	13	integration	integration	NOUN
gs-3799	270	14	of	of	ADP
gs-3799	270	15	automation	automation	NOUN
gs-3799	270	16	in	in	ADP
gs-3799	270	17	high	high	ADJ
gs-3799	270	18	-	-	PUNCT
gs-3799	270	19	risk	risk	NOUN
gs-3799	270	20	pediatric	pediatric	ADJ
gs-3799	270	21	surgeries	surgery	NOUN
gs-3799	270	22	.	.	PUNCT
gs-3799	271	1	patient	patient	ADJ
gs-3799	271	2	safety	safety	NOUN
gs-3799	271	3	to	to	PART
gs-3799	271	4	ensure	ensure	VERB
gs-3799	271	5	that	that	SCONJ
gs-3799	271	6	these	these	DET
gs-3799	271	7	systems	system	NOUN
gs-3799	271	8	do	do	AUX
gs-3799	271	9	not	not	PART
gs-3799	271	10	run	run	VERB
gs-3799	271	11	the	the	DET
gs-3799	271	12	risk	risk	NOUN
gs-3799	271	13	of	of	ADP
gs-3799	271	14	compromising	compromise	VERB
gs-3799	271	15	patient	patient	ADJ
gs-3799	271	16	care	care	NOUN
gs-3799	271	17	.	.	PUNCT
gs-3799	272	1	gaining	gain	VERB
gs-3799	272	2	informed	informed	ADJ
gs-3799	272	3	consent	consent	NOUN
gs-3799	272	4	,	,	PUNCT
gs-3799	272	5	where	where	SCONJ
gs-3799	272	6	the	the	DET
gs-3799	272	7	role	role	NOUN
gs-3799	272	8	of	of	ADP
gs-3799	272	9	automation	automation	NOUN
gs-3799	272	10	must	must	AUX
gs-3799	272	11	be	be	AUX
gs-3799	272	12	explained	explain	VERB
gs-3799	272	13	to	to	ADP
gs-3799	272	14	the	the	DET
gs-3799	272	15	concerned	concerned	ADJ
gs-3799	272	16	families	family	NOUN
gs-3799	272	17	.	.	PUNCT
gs-3799	273	1	accountability	accountability	NOUN
gs-3799	273	2	in	in	ADP
gs-3799	273	3	the	the	DET
gs-3799	273	4	event	event	NOUN
gs-3799	273	5	of	of	ADP
gs-3799	273	6	system	system	NOUN
gs-3799	273	7	failures	failure	NOUN
gs-3799	273	8	must	must	AUX
gs-3799	273	9	be	be	AUX
gs-3799	273	10	taken	take	VERB
gs-3799	273	11	into	into	ADP
gs-3799	273	12	consideration	consideration	NOUN
gs-3799	273	13	.	.	PUNCT
gs-3799	274	1	these	these	DET
gs-3799	274	2	considerations	consideration	NOUN
gs-3799	274	3	require	require	VERB
gs-3799	274	4	cautious	cautious	ADJ
gs-3799	274	5	navigation	navigation	NOUN
gs-3799	274	6	to	to	PART
gs-3799	274	7	keep	keep	VERB
gs-3799	274	8	technological	technological	ADJ
gs-3799	274	9	advancements	advancement	NOUN
gs-3799	274	10	&	&	CCONJ
gs-3799	274	11	ethical	ethical	ADJ
gs-3799	274	12	obligations	obligation	NOUN
gs-3799	274	13	balanced	balanced	ADJ
gs-3799	274	14	.	.	PUNCT
gs-3799	275	1	potential	potential	ADJ
gs-3799	275	2	challenges	challenge	NOUN
gs-3799	275	3	&	&	CCONJ
gs-3799	275	4	mitigations	mitigation	NOUN
gs-3799	275	5	:	:	PUNCT
gs-3799	275	6	limited	limit	VERB
gs-3799	275	7	high	high	ADJ
gs-3799	275	8	-	-	PUNCT
gs-3799	275	9	quality	quality	NOUN
gs-3799	275	10	evidence	evidence	NOUN
gs-3799	275	11	(	(	PUNCT
gs-3799	275	12	esp	esp	ADJ
gs-3799	275	13	.	.	PUNCT
gs-3799	276	1	rcts	rct	NOUN
gs-3799	276	2	):	):	PUNCT
gs-3799	276	3	mitigation	mitigation	NOUN
gs-3799	276	4	:	:	PUNCT
gs-3799	276	5	include	include	VERB
gs-3799	276	6	all	all	DET
gs-3799	276	7	relevant	relevant	ADJ
gs-3799	276	8	comparative	comparative	ADJ
gs-3799	276	9	designs	design	NOUN
gs-3799	276	10	;	;	PUNCT
gs-3799	276	11	use	use	VERB
gs-3799	276	12	rigorous	rigorous	ADJ
gs-3799	276	13	rob	rob	PROPN
gs-3799	276	14	assessment	assessment	NOUN
gs-3799	276	15	;	;	PUNCT
gs-3799	276	16	transparently	transparently	ADV
gs-3799	276	17	report	report	VERB
gs-3799	276	18	limitations	limitation	NOUN
gs-3799	276	19	;	;	PUNCT
gs-3799	276	20	prioritize	prioritize	VERB
gs-3799	276	21	future	future	ADJ
gs-3799	276	22	rcts	rct	NOUN
gs-3799	276	23	in	in	ADP
gs-3799	276	24	aim	aim	NOUN
gs-3799	276	25	5	5	NUM
gs-3799	276	26	.	.	PUNCT
gs-3799	277	1	georgian	georgian	NOUN
gs-3799	277	2	scientists/	scientists/	NUM
gs-3799	277	3	.	.	PUNCT
gs-3799	278	1	7	7	NUM
gs-3799	278	2	n	n	PRON
gs-3799	278	3	2	2	NUM
gs-3799	278	4	,	,	PUNCT
gs-3799	278	5	2025	2025	NUM
gs-3799	278	6	395	395	NUM
gs-3799	278	7	heterogeneity	heterogeneity	NOUN
gs-3799	278	8	of	of	ADP
gs-3799	278	9	systems	system	NOUN
gs-3799	278	10	&	&	CCONJ
gs-3799	278	11	outcomes	outcome	NOUN
gs-3799	278	12	:	:	PUNCT
gs-3799	278	13	mitigation	mitigation	NOUN
gs-3799	278	14	:	:	PUNCT
gs-3799	278	15	clear	clear	ADJ
gs-3799	278	16	definitions	definition	NOUN
gs-3799	278	17	upfront	upfront	VERB
gs-3799	278	18	;	;	PUNCT
gs-3799	278	19	subgroup	subgroup	NOUN
gs-3799	278	20	/	/	SYM
gs-3799	278	21	sensitivity	sensitivity	NOUN
gs-3799	278	22	analysis	analysis	NOUN
gs-3799	278	23	;	;	PUNCT
gs-3799	278	24	prioritize	prioritize	VERB
gs-3799	278	25	narrative	narrative	ADJ
gs-3799	278	26	synthesis	synthesis	NOUN
gs-3799	278	27	where	where	SCONJ
gs-3799	278	28	meta	meta	VERB
gs-3799	278	29	-	-	PUNCT
gs-3799	278	30	analysis	analysis	NOUN
gs-3799	278	31	impossible	impossible	ADJ
gs-3799	278	32	;	;	PUNCT
gs-3799	278	33	use	use	VERB
gs-3799	278	34	smd	smd	NOUN
gs-3799	278	35	carefully	carefully	ADV
gs-3799	278	36	.	.	PUNCT
gs-3799	279	1	defining	define	VERB
gs-3799	279	2	"	"	PUNCT
gs-3799	279	3	closed	closed	ADJ
gs-3799	279	4	-	-	PUNCT
gs-3799	279	5	loop	loop	NOUN
gs-3799	279	6	"	"	PUNCT
gs-3799	279	7	:	:	PUNCT
gs-3799	279	8	mitigation	mitigation	NOUN
gs-3799	279	9	:	:	PUNCT
gs-3799	279	10	initial	initial	ADJ
gs-3799	279	11	consensus	consensus	NOUN
gs-3799	279	12	step	step	NOUN
gs-3799	279	13	;	;	PUNCT
gs-3799	279	14	document	document	NOUN
gs-3799	279	15	definitions	definition	NOUN
gs-3799	279	16	transparently	transparently	ADV
gs-3799	279	17	.	.	PUNCT
gs-3799	280	1	accessing	access	VERB
gs-3799	280	2	grey	grey	PROPN
gs-3799	280	3	literature	literature	PROPN
gs-3799	280	4	/	/	SYM
gs-3799	280	5	proprietary	proprietary	ADJ
gs-3799	280	6	data	datum	NOUN
gs-3799	280	7	:	:	PUNCT
gs-3799	280	8	mitigation	mitigation	NOUN
gs-3799	280	9	:	:	PUNCT
gs-3799	280	10	comprehensive	comprehensive	ADJ
gs-3799	280	11	search	search	NOUN
gs-3799	280	12	strategy	strategy	NOUN
gs-3799	280	13	;	;	PUNCT
gs-3799	280	14	contact	contact	NOUN
gs-3799	280	15	manufacturers	manufacturer	NOUN
gs-3799	280	16	;	;	PUNCT
gs-3799	280	17	acknowledge	acknowledge	VERB
gs-3799	280	18	potential	potential	ADJ
gs-3799	280	19	publication	publication	NOUN
gs-3799	280	20	bias	bias	NOUN
gs-3799	280	21	.	.	PUNCT
gs-3799	281	1	expert	expert	ADJ
gs-3799	281	2	availability	availability	NOUN
gs-3799	281	3	for	for	ADP
gs-3799	281	4	delphi	delphi	NOUN
gs-3799	281	5	:	:	PUNCT
gs-3799	281	6	mitigation	mitigation	NOUN
gs-3799	281	7	:	:	PUNCT
gs-3799	281	8	careful	careful	ADJ
gs-3799	281	9	panelist	panelist	NOUN
gs-3799	281	10	selection	selection	NOUN
gs-3799	281	11	emphasizing	emphasize	VERB
gs-3799	281	12	relevance	relevance	NOUN
gs-3799	281	13	;	;	PUNCT
gs-3799	281	14	efficient	efficient	ADJ
gs-3799	281	15	survey	survey	NOUN
gs-3799	281	16	design	design	NOUN
gs-3799	281	17	;	;	PUNCT
gs-3799	281	18	appropriate	appropriate	ADJ
gs-3799	281	19	incentives	incentive	NOUN
gs-3799	281	20	.	.	PUNCT
gs-3799	282	1	results	result	NOUN
gs-3799	282	2	&	&	CCONJ
gs-3799	282	3	discussion	discussion	NOUN
gs-3799	282	4	the	the	DET
gs-3799	282	5	forming	forming	NOUN
gs-3799	282	6	of	of	ADP
gs-3799	282	7	reviewed	review	VERB
gs-3799	282	8	writings	writing	NOUN
gs-3799	282	9	and	and	CCONJ
gs-3799	282	10	technological	technological	ADJ
gs-3799	282	11	analyses	analysis	NOUN
gs-3799	282	12	highlights	highlight	NOUN
gs-3799	282	13	potential	potential	ADJ
gs-3799	282	14	advancements	advancement	NOUN
gs-3799	282	15	in	in	ADP
gs-3799	282	16	closed	closed	ADJ
gs-3799	282	17	-	-	PUNCT
gs-3799	282	18	loop	loop	NOUN
gs-3799	282	19	cpb	cpb	NOUN
gs-3799	282	20	systems	system	NOUN
gs-3799	282	21	,	,	PUNCT
gs-3799	282	22	especially	especially	ADV
gs-3799	282	23	in	in	ADP
gs-3799	282	24	terms	term	NOUN
gs-3799	282	25	of	of	ADP
gs-3799	282	26	pediatric	pediatric	ADJ
gs-3799	282	27	cardiac	cardiac	ADJ
gs-3799	282	28	surgery	surgery	NOUN
gs-3799	282	29	.	.	PUNCT
gs-3799	283	1	a	a	DET
gs-3799	283	2	variety	variety	NOUN
gs-3799	283	3	of	of	ADP
gs-3799	283	4	experimental	experimental	ADJ
gs-3799	283	5	alongside	alongside	ADP
gs-3799	283	6	early	early	ADJ
gs-3799	283	7	-	-	PUNCT
gs-3799	283	8	phase	phase	NOUN
gs-3799	283	9	clinical	clinical	ADJ
gs-3799	283	10	studies	study	NOUN
gs-3799	283	11	exemplify	exemplify	VERB
gs-3799	283	12	that	that	SCONJ
gs-3799	283	13	these	these	DET
gs-3799	283	14	systems	system	NOUN
gs-3799	283	15	outwork	outwork	VERB
gs-3799	283	16	conventional	conventional	ADJ
gs-3799	283	17	open	open	ADJ
gs-3799	283	18	-	-	PUNCT
gs-3799	283	19	loop	loop	NOUN
gs-3799	283	20	systems	system	NOUN
gs-3799	283	21	in	in	ADP
gs-3799	283	22	demonstrating	demonstrate	VERB
gs-3799	283	23	stable	stable	ADJ
gs-3799	283	24	hemodynamic	hemodynamic	ADJ
gs-3799	283	25	parameters	parameter	NOUN
gs-3799	283	26	and	and	CCONJ
gs-3799	283	27	to	to	PART
gs-3799	283	28	cut	cut	VERB
gs-3799	283	29	down	down	ADP
gs-3799	283	30	intraoperative	intraoperative	ADJ
gs-3799	283	31	fluctuations	fluctuation	NOUN
gs-3799	283	32	.	.	PUNCT
gs-3799	284	1	particularly	particularly	ADV
gs-3799	284	2	,	,	PUNCT
gs-3799	284	3	prototype	prototype	NOUN
gs-3799	284	4	closed	close	VERB
gs-3799	284	5	-	-	PUNCT
gs-3799	284	6	loop	loop	NOUN
gs-3799	284	7	systems	system	NOUN
gs-3799	284	8	combining	combine	VERB
gs-3799	284	9	real	real	ADJ
gs-3799	284	10	-	-	PUNCT
gs-3799	284	11	time	time	NOUN
gs-3799	284	12	monitoring	monitoring	NOUN
gs-3799	284	13	of	of	ADP
gs-3799	284	14	mean	mean	ADJ
gs-3799	284	15	arterial	arterial	ADJ
gs-3799	284	16	pressure	pressure	NOUN
gs-3799	284	17	(	(	PUNCT
gs-3799	284	18	map	map	NOUN
gs-3799	284	19	)	)	PUNCT
gs-3799	284	20	,	,	PUNCT
gs-3799	284	21	venous	venous	ADJ
gs-3799	284	22	oxygen	oxygen	NOUN
gs-3799	284	23	saturation	saturation	NOUN
gs-3799	284	24	(	(	PUNCT
gs-3799	284	25	svo	svo	NOUN
gs-3799	284	26	)	)	PUNCT
gs-3799	284	27	,	,	PUNCT
gs-3799	284	28	and	and	CCONJ
gs-3799	284	29	cerebral	cerebral	ADJ
gs-3799	284	30	oxygenation	oxygenation	NOUN
gs-3799	284	31	through	through	ADP
gs-3799	284	32	near	near	ADV
gs-3799	284	33	-	-	PUNCT
gs-3799	284	34	infrared	infrared	ADJ
gs-3799	284	35	spectroscopy	spectroscopy	NOUN
gs-3799	284	36	(	(	PUNCT
gs-3799	284	37	nirs	nir	NOUN
gs-3799	284	38	)	)	PUNCT
gs-3799	284	39	have	have	AUX
gs-3799	284	40	signified	signify	VERB
gs-3799	284	41	improved	improved	ADJ
gs-3799	284	42	balance	balance	NOUN
gs-3799	284	43	of	of	ADP
gs-3799	284	44	perfusion	perfusion	NOUN
gs-3799	284	45	flow	flow	NOUN
gs-3799	284	46	,	,	PUNCT
gs-3799	284	47	oxygen	oxygen	NOUN
gs-3799	284	48	delivery	delivery	NOUN
gs-3799	284	49	,	,	PUNCT
gs-3799	284	50	and	and	CCONJ
gs-3799	284	51	temperature	temperature	NOUN
gs-3799	284	52	control	control	NOUN
gs-3799	284	53	in	in	ADP
gs-3799	284	54	contrast	contrast	NOUN
gs-3799	284	55	to	to	ADP
gs-3799	284	56	manually	manually	ADV
gs-3799	284	57	adjusted	adjust	VERB
gs-3799	284	58	systems	system	NOUN
gs-3799	284	59	.	.	PUNCT
gs-3799	285	1	something	something	PRON
gs-3799	285	2	very	very	ADV
gs-3799	285	3	engaging	engaging	ADJ
gs-3799	285	4	to	to	PART
gs-3799	285	5	highlight	highlight	VERB
gs-3799	285	6	here	here	ADV
gs-3799	285	7	is	be	AUX
gs-3799	285	8	that	that	SCONJ
gs-3799	285	9	closed	closed	ADJ
gs-3799	285	10	-	-	PUNCT
gs-3799	285	11	loop	loop	NOUN
gs-3799	285	12	systems	system	NOUN
gs-3799	285	13	with	with	ADP
gs-3799	285	14	real	real	ADJ
gs-3799	285	15	duration	duration	NOUN
gs-3799	285	16	of	of	ADP
gs-3799	285	17	monitoring	monitoring	NOUN
gs-3799	285	18	can	can	AUX
gs-3799	285	19	adhere	adhere	VERB
gs-3799	285	20	more	more	ADV
gs-3799	285	21	quickly	quickly	ADV
gs-3799	285	22	and	and	CCONJ
gs-3799	285	23	accurately	accurately	ADV
gs-3799	285	24	to	to	ADP
gs-3799	285	25	fast	fast	ADJ
gs-3799	285	26	physiological	physiological	ADJ
gs-3799	285	27	replacements	replacement	NOUN
gs-3799	285	28	,	,	PUNCT
gs-3799	285	29	especially	especially	ADV
gs-3799	285	30	those	those	PRON
gs-3799	285	31	formed	form	VERB
gs-3799	285	32	by	by	ADP
gs-3799	285	33	fluctuations	fluctuation	NOUN
gs-3799	285	34	in	in	ADP
gs-3799	285	35	fluids	fluid	NOUN
gs-3799	285	36	or	or	CCONJ
gs-3799	285	37	temperature	temperature	NOUN
gs-3799	285	38	changes	change	NOUN
gs-3799	285	39	,	,	PUNCT
gs-3799	285	40	as	as	SCONJ
gs-3799	285	41	studied	study	VERB
gs-3799	285	42	and	and	CCONJ
gs-3799	285	43	analyzed	analyze	VERB
gs-3799	285	44	during	during	ADP
gs-3799	285	45	pediatric	pediatric	ADJ
gs-3799	285	46	cardiac	cardiac	ADJ
gs-3799	285	47	surgery	surgery	NOUN
gs-3799	285	48	.	.	PUNCT
gs-3799	286	1	in	in	ADP
gs-3799	286	2	animal	animal	NOUN
gs-3799	286	3	models	model	NOUN
gs-3799	286	4	,	,	PUNCT
gs-3799	286	5	these	these	DET
gs-3799	286	6	systems	system	NOUN
gs-3799	286	7	decreased	decrease	VERB
gs-3799	286	8	the	the	DET
gs-3799	286	9	occurrence	occurrence	NOUN
gs-3799	286	10	of	of	ADP
gs-3799	286	11	inadequate	inadequate	ADJ
gs-3799	286	12	perfusion	perfusion	NOUN
gs-3799	286	13	and	and	CCONJ
gs-3799	286	14	oxygen	oxygen	NOUN
gs-3799	286	15	debt	debt	NOUN
gs-3799	286	16	.	.	PUNCT
gs-3799	287	1	in	in	ADP
gs-3799	287	2	initial	initial	ADJ
gs-3799	287	3	pediatric	pediatric	ADJ
gs-3799	287	4	human	human	ADJ
gs-3799	287	5	trials	trial	NOUN
gs-3799	287	6	,	,	PUNCT
gs-3799	287	7	enhanced	enhance	VERB
gs-3799	287	8	perfusion	perfusion	NOUN
gs-3799	287	9	numbers	number	NOUN
gs-3799	287	10	reduced	reduce	VERB
gs-3799	287	11	lactate	lactate	NOUN
gs-3799	287	12	levels	level	NOUN
gs-3799	287	13	,	,	PUNCT
gs-3799	287	14	and	and	CCONJ
gs-3799	287	15	reduced	reduce	VERB
gs-3799	287	16	response	response	NOUN
gs-3799	287	17	times	time	NOUN
gs-3799	287	18	to	to	ADP
gs-3799	287	19	hypotensive	hypotensive	ADJ
gs-3799	287	20	events	event	NOUN
gs-3799	287	21	were	be	AUX
gs-3799	287	22	monitored	monitor	VERB
gs-3799	287	23	.	.	PUNCT
gs-3799	288	1	additionally	additionally	ADV
gs-3799	288	2	,	,	PUNCT
gs-3799	288	3	some	some	DET
gs-3799	288	4	systems	system	NOUN
gs-3799	288	5	comprised	comprise	VERB
gs-3799	288	6	predictive	predictive	ADJ
gs-3799	288	7	algorithms	algorithm	NOUN
gs-3799	288	8	capable	capable	ADJ
gs-3799	288	9	of	of	ADP
gs-3799	288	10	recognizing	recognize	VERB
gs-3799	288	11	the	the	DET
gs-3799	288	12	undermined	undermined	ADJ
gs-3799	288	13	patterns	pattern	NOUN
gs-3799	288	14	before	before	SCONJ
gs-3799	288	15	clinical	clinical	ADJ
gs-3799	288	16	thresholds	threshold	NOUN
gs-3799	288	17	were	be	AUX
gs-3799	288	18	violated	violate	VERB
gs-3799	288	19	,	,	PUNCT
gs-3799	288	20	thus	thus	ADV
gs-3799	288	21	enabling	enable	VERB
gs-3799	288	22	preventive	preventive	ADJ
gs-3799	288	23	adjustments	adjustment	NOUN
gs-3799	288	24	.	.	PUNCT
gs-3799	289	1	in	in	ADP
gs-3799	289	2	spite	spite	NOUN
gs-3799	289	3	of	of	ADP
gs-3799	289	4	these	these	DET
gs-3799	289	5	upgrades	upgrade	NOUN
gs-3799	289	6	,	,	PUNCT
gs-3799	289	7	remarkable	remarkable	ADJ
gs-3799	289	8	hindrances	hindrance	NOUN
gs-3799	289	9	are	be	AUX
gs-3799	289	10	evident	evident	ADJ
gs-3799	289	11	.	.	PUNCT
gs-3799	290	1	the	the	DET
gs-3799	290	2	adverse	adverse	ADJ
gs-3799	290	3	effects	effect	NOUN
gs-3799	290	4	of	of	ADP
gs-3799	290	5	combining	combine	VERB
gs-3799	290	6	multiple	multiple	ADJ
gs-3799	290	7	real	real	ADJ
gs-3799	290	8	-	-	PUNCT
gs-3799	290	9	time	time	NOUN
gs-3799	290	10	monitoring	monitoring	NOUN
gs-3799	290	11	technologies	technology	NOUN
gs-3799	290	12	such	such	ADJ
gs-3799	290	13	as	as	ADP
gs-3799	290	14	nirs	nir	NOUN
gs-3799	290	15	,	,	PUNCT
gs-3799	290	16	pulse	pulse	VERB
gs-3799	290	17	contour	contour	NOUN
gs-3799	290	18	analysis	analysis	NOUN
gs-3799	290	19	,	,	PUNCT
gs-3799	290	20	thermodilution	thermodilution	NOUN
gs-3799	290	21	sensors	sensor	NOUN
gs-3799	290	22	into	into	ADP
gs-3799	290	23	a	a	DET
gs-3799	290	24	single	single	ADJ
gs-3799	290	25	merged	merged	ADJ
gs-3799	290	26	control	control	NOUN
gs-3799	290	27	method	method	NOUN
gs-3799	290	28	leads	lead	VERB
gs-3799	290	29	to	to	ADP
gs-3799	290	30	technical	technical	ADJ
gs-3799	290	31	challenges	challenge	NOUN
gs-3799	290	32	.	.	PUNCT
gs-3799	291	1	furthermore	furthermore	ADV
gs-3799	291	2	,	,	PUNCT
gs-3799	291	3	ethical	ethical	ADJ
gs-3799	291	4	and	and	CCONJ
gs-3799	291	5	maintenance	maintenance	NOUN
gs-3799	291	6	concerns	concern	NOUN
gs-3799	291	7	over	over	ADP
gs-3799	291	8	complete	complete	ADJ
gs-3799	291	9	mechanisation	mechanisation	NOUN
gs-3799	291	10	in	in	ADP
gs-3799	291	11	dangerous	dangerous	ADJ
gs-3799	291	12	techniques	technique	NOUN
gs-3799	291	13	like	like	ADP
gs-3799	291	14	neonatal	neonatal	ADJ
gs-3799	291	15	heart	heart	NOUN
gs-3799	291	16	surgery	surgery	NOUN
gs-3799	291	17	block	block	NOUN
gs-3799	291	18	fast	fast	ADJ
gs-3799	291	19	validation	validation	NOUN
gs-3799	291	20	.	.	PUNCT
gs-3799	292	1	problems	problem	NOUN
gs-3799	292	2	also	also	ADV
gs-3799	292	3	continue	continue	VERB
gs-3799	292	4	about	about	ADP
gs-3799	292	5	the	the	DET
gs-3799	292	6	efficiency	efficiency	NOUN
gs-3799	292	7	of	of	ADP
gs-3799	292	8	sensors	sensor	NOUN
gs-3799	292	9	in	in	ADP
gs-3799	292	10	neonates	neonate	NOUN
gs-3799	292	11	,	,	PUNCT
gs-3799	292	12	where	where	SCONJ
gs-3799	292	13	vasoconstriction	vasoconstriction	NOUN
gs-3799	292	14	,	,	PUNCT
gs-3799	292	15	small	small	ADJ
gs-3799	292	16	vessel	vessel	NOUN
gs-3799	292	17	size	size	NOUN
gs-3799	292	18	,	,	PUNCT
gs-3799	292	19	and	and	CCONJ
gs-3799	292	20	motion	motion	NOUN
gs-3799	292	21	artifacts	artifact	NOUN
gs-3799	292	22	can	can	AUX
gs-3799	292	23	strike	strike	VERB
gs-3799	292	24	a	a	DET
gs-3799	292	25	balance	balance	NOUN
gs-3799	292	26	on	on	ADP
gs-3799	292	27	the	the	DET
gs-3799	292	28	trustworthiness	trustworthiness	NOUN
gs-3799	292	29	of	of	ADP
gs-3799	292	30	data	datum	NOUN
gs-3799	292	31	.	.	PUNCT
gs-3799	293	1	perfusionists	perfusionist	NOUN
gs-3799	293	2	when	when	SCONJ
gs-3799	293	3	asked	ask	VERB
gs-3799	293	4	in	in	ADP
gs-3799	293	5	this	this	DET
gs-3799	293	6	study	study	NOUN
gs-3799	293	7	implied	imply	VERB
gs-3799	293	8	and	and	CCONJ
gs-3799	293	9	highlighted	highlight	VERB
gs-3799	293	10	the	the	DET
gs-3799	293	11	need	need	NOUN
gs-3799	293	12	for	for	SCONJ
gs-3799	293	13	systems	system	NOUN
gs-3799	293	14	to	to	PART
gs-3799	293	15	have	have	VERB
gs-3799	293	16	manual	manual	ADJ
gs-3799	293	17	override	override	NOUN
gs-3799	293	18	competencies	competency	NOUN
gs-3799	293	19	and	and	CCONJ
gs-3799	293	20	clear	clear	ADJ
gs-3799	293	21	feedback	feedback	NOUN
gs-3799	293	22	processes	process	NOUN
gs-3799	293	23	to	to	PART
gs-3799	293	24	guarantee	guarantee	VERB
gs-3799	293	25	trust	trust	NOUN
gs-3799	293	26	and	and	CCONJ
gs-3799	293	27	safety	safety	NOUN
gs-3799	293	28	in	in	ADP
gs-3799	293	29	clinical	clinical	ADJ
gs-3799	293	30	environments	environment	NOUN
gs-3799	293	31	.	.	PUNCT
gs-3799	294	1	to	to	PART
gs-3799	294	2	add	add	VERB
gs-3799	294	3	to	to	ADP
gs-3799	294	4	this	this	PRON
gs-3799	294	5	,	,	PUNCT
gs-3799	294	6	cost	cost	NOUN
gs-3799	294	7	and	and	CCONJ
gs-3799	294	8	training	train	VERB
gs-3799	294	9	pre	pre	NOUN
gs-3799	294	10	requisites	requisite	NOUN
gs-3799	294	11	still	still	ADV
gs-3799	294	12	stand	stand	VERB
gs-3799	294	13	barriers	barrier	NOUN
gs-3799	294	14	to	to	ADP
gs-3799	294	15	extensive	extensive	ADJ
gs-3799	294	16	execution	execution	NOUN
gs-3799	294	17	and	and	CCONJ
gs-3799	294	18	performance	performance	NOUN
gs-3799	294	19	.	.	PUNCT
gs-3799	295	1	the	the	DET
gs-3799	295	2	financial	financial	ADJ
gs-3799	295	3	investment	investment	NOUN
gs-3799	295	4	needed	need	VERB
gs-3799	295	5	to	to	PART
gs-3799	295	6	evolve	evolve	VERB
gs-3799	295	7	,	,	PUNCT
gs-3799	295	8	examine	examine	VERB
gs-3799	295	9	,	,	PUNCT
gs-3799	295	10	and	and	CCONJ
gs-3799	295	11	ensure	ensure	VERB
gs-3799	295	12	closed	closed	ADJ
gs-3799	295	13	-	-	PUNCT
gs-3799	295	14	loop	loop	NOUN
gs-3799	295	15	systems	system	NOUN
gs-3799	295	16	can	can	AUX
gs-3799	295	17	be	be	AUX
gs-3799	295	18	fundamental	fundamental	ADJ
gs-3799	295	19	,	,	PUNCT
gs-3799	295	20	and	and	CCONJ
gs-3799	295	21	extra	extra	ADJ
gs-3799	295	22	time	time	NOUN
gs-3799	295	23	is	be	AUX
gs-3799	295	24	required	require	VERB
gs-3799	295	25	to	to	PART
gs-3799	295	26	coach	coach	VERB
gs-3799	295	27	surgical	surgical	ADJ
gs-3799	295	28	teams	team	NOUN
gs-3799	295	29	in	in	ADP
gs-3799	295	30	their	their	PRON
gs-3799	295	31	use	use	NOUN
gs-3799	295	32	.	.	PUNCT
gs-3799	296	1	nonetheless	nonetheless	ADV
gs-3799	296	2	,	,	PUNCT
gs-3799	296	3	expert	expert	ADJ
gs-3799	296	4	georgian	georgian	NOUN
gs-3799	296	5	scientists/	scientists/	NUM
gs-3799	296	6	.	.	PUNCT
gs-3799	297	1	7	7	NUM
gs-3799	297	2	n	n	DET
gs-3799	297	3	2	2	NUM
gs-3799	297	4	,	,	PUNCT
gs-3799	297	5	2025	2025	NUM
gs-3799	297	6	396	396	NUM
gs-3799	298	1	agreemnent	agreemnent	ADJ
gs-3799	298	2	supports	support	VERB
gs-3799	298	3	pursuant	pursuant	ADJ
gs-3799	298	4	development	development	NOUN
gs-3799	298	5	,	,	PUNCT
gs-3799	298	6	with	with	ADP
gs-3799	298	7	most	most	ADV
gs-3799	298	8	expecting	expect	VERB
gs-3799	298	9	a	a	DET
gs-3799	298	10	hybrid	hybrid	ADJ
gs-3799	298	11	future	future	NOUN
gs-3799	298	12	where	where	SCONJ
gs-3799	298	13	closed	closed	ADJ
gs-3799	298	14	-	-	PUNCT
gs-3799	298	15	loop	loop	NOUN
gs-3799	298	16	systems	system	NOUN
gs-3799	298	17	support	support	NOUN
gs-3799	298	18	but	but	CCONJ
gs-3799	298	19	do	do	AUX
gs-3799	298	20	not	not	PART
gs-3799	298	21	substitute	substitute	VERB
gs-3799	298	22	human	human	ADJ
gs-3799	298	23	oversight	oversight	NOUN
gs-3799	298	24	during	during	ADP
gs-3799	298	25	cpb	cpb	PROPN
gs-3799	298	26	.	.	PUNCT
gs-3799	298	27	to	to	PART
gs-3799	298	28	conclude	conclude	VERB
gs-3799	298	29	and	and	CCONJ
gs-3799	298	30	summarize	summarize	VERB
gs-3799	298	31	,	,	PUNCT
gs-3799	298	32	closed	closed	ADJ
gs-3799	298	33	-	-	PUNCT
gs-3799	298	34	loop	loop	NOUN
gs-3799	298	35	cpb	cpb	NOUN
gs-3799	298	36	systems	system	NOUN
gs-3799	298	37	with	with	ADP
gs-3799	298	38	real	real	ADJ
gs-3799	298	39	-	-	PUNCT
gs-3799	298	40	time	time	NOUN
gs-3799	298	41	observation	observation	NOUN
gs-3799	298	42	speak	speak	VERB
gs-3799	298	43	for	for	ADP
gs-3799	298	44	significant	significant	ADJ
gs-3799	298	45	innovation	innovation	NOUN
gs-3799	298	46	with	with	ADP
gs-3799	298	47	the	the	DET
gs-3799	298	48	capabilities	capability	NOUN
gs-3799	298	49	to	to	PART
gs-3799	298	50	further	far	ADV
gs-3799	298	51	strengthen	strengthen	VERB
gs-3799	298	52	safety	safety	NOUN
gs-3799	298	53	and	and	CCONJ
gs-3799	298	54	effictiveness	effictiveness	NOUN
gs-3799	298	55	in	in	ADP
gs-3799	298	56	pediatric	pediatric	ADJ
gs-3799	298	57	cardiac	cardiac	ADJ
gs-3799	298	58	surgery	surgery	NOUN
gs-3799	298	59	.	.	PUNCT
gs-3799	299	1	their	their	PRON
gs-3799	299	2	potential	potential	NOUN
gs-3799	299	3	to	to	PART
gs-3799	299	4	consistenly	consistenly	ADV
gs-3799	299	5	monitor	monitor	VERB
gs-3799	299	6	and	and	CCONJ
gs-3799	299	7	regulaye	regulaye	VERB
gs-3799	299	8	perfusion	perfusion	NOUN
gs-3799	299	9	in	in	ADP
gs-3799	299	10	feedback	feedback	NOUN
gs-3799	299	11	to	to	ADP
gs-3799	299	12	patientspecific	patientspecific	ADJ
gs-3799	299	13	variations	variation	NOUN
gs-3799	299	14	may	may	AUX
gs-3799	299	15	decrease	decrease	VERB
gs-3799	299	16	postoperative	postoperative	ADJ
gs-3799	299	17	issues	issue	NOUN
gs-3799	299	18	,	,	PUNCT
gs-3799	299	19	including	include	VERB
gs-3799	299	20	neurological	neurological	ADJ
gs-3799	299	21	injury	injury	NOUN
gs-3799	299	22	and	and	CCONJ
gs-3799	299	23	renal	renal	ADJ
gs-3799	299	24	dysfunction	dysfunction	NOUN
gs-3799	299	25	.	.	PUNCT
gs-3799	300	1	but	but	CCONJ
gs-3799	300	2	,	,	PUNCT
gs-3799	300	3	additional	additional	ADJ
gs-3799	300	4	multicenter	multicenter	ADJ
gs-3799	300	5	clinical	clinical	ADJ
gs-3799	300	6	trials	trial	NOUN
gs-3799	300	7	,	,	PUNCT
gs-3799	300	8	pediatric	pediatric	ADJ
gs-3799	300	9	-	-	PUNCT
gs-3799	300	10	specific	specific	ADJ
gs-3799	300	11	technique	technique	NOUN
gs-3799	300	12	optimization	optimization	NOUN
gs-3799	300	13	,	,	PUNCT
gs-3799	300	14	and	and	CCONJ
gs-3799	300	15	cost	cost	NOUN
gs-3799	300	16	-	-	PUNCT
gs-3799	300	17	effective	effective	ADJ
gs-3799	300	18	system	system	NOUN
gs-3799	300	19	designs	design	NOUN
gs-3799	300	20	are	be	AUX
gs-3799	300	21	an	an	DET
gs-3799	300	22	obligation	obligation	NOUN
gs-3799	300	23	to	to	PART
gs-3799	300	24	help	help	VERB
gs-3799	300	25	assist	assist	VERB
gs-3799	300	26	in	in	ADP
gs-3799	300	27	wider	wide	ADJ
gs-3799	300	28	clinical	clinical	ADJ
gs-3799	300	29	application	application	NOUN
gs-3799	300	30	.	.	PUNCT
gs-3799	301	1	the	the	DET
gs-3799	301	2	implementation	implementation	NOUN
gs-3799	301	3	of	of	ADP
gs-3799	301	4	closed	closed	ADJ
gs-3799	301	5	-	-	PUNCT
gs-3799	301	6	loop	loop	NOUN
gs-3799	301	7	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	301	8	bypass	bypass	NOUN
gs-3799	301	9	(	(	PUNCT
gs-3799	301	10	cpb	cpb	NOUN
gs-3799	301	11	)	)	PUNCT
gs-3799	301	12	systems	system	NOUN
gs-3799	301	13	with	with	ADP
gs-3799	301	14	integrated	integrate	VERB
gs-3799	301	15	real	real	ADJ
gs-3799	301	16	-	-	PUNCT
gs-3799	301	17	time	time	NOUN
gs-3799	301	18	monitoring	monitoring	NOUN
gs-3799	301	19	and	and	CCONJ
gs-3799	301	20	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-3799	301	21	intervention	intervention	NOUN
gs-3799	301	22	marks	mark	VERB
gs-3799	301	23	a	a	DET
gs-3799	301	24	transformative	transformative	ADJ
gs-3799	301	25	approach	approach	NOUN
gs-3799	301	26	in	in	ADP
gs-3799	301	27	extracorporeal	extracorporeal	NOUN
gs-3799	301	28	circulation	circulation	NOUN
gs-3799	301	29	management	management	NOUN
gs-3799	301	30	.	.	PUNCT
gs-3799	302	1	various	various	ADJ
gs-3799	302	2	pilot	pilot	NOUN
gs-3799	302	3	studies	study	NOUN
gs-3799	302	4	,	,	PUNCT
gs-3799	302	5	experimental	experimental	ADJ
gs-3799	302	6	models	model	NOUN
gs-3799	302	7	,	,	PUNCT
gs-3799	302	8	and	and	CCONJ
gs-3799	302	9	early	early	ADJ
gs-3799	302	10	clinical	clinical	ADJ
gs-3799	302	11	trials	trial	NOUN
gs-3799	302	12	have	have	AUX
gs-3799	302	13	explored	explore	VERB
gs-3799	302	14	the	the	DET
gs-3799	302	15	impact	impact	NOUN
gs-3799	302	16	of	of	ADP
gs-3799	302	17	closed	closed	ADJ
gs-3799	302	18	-	-	PUNCT
gs-3799	302	19	loop	loop	NOUN
gs-3799	302	20	technology	technology	NOUN
gs-3799	302	21	on	on	ADP
gs-3799	302	22	intraoperative	intraoperative	ADJ
gs-3799	302	23	stability	stability	NOUN
gs-3799	302	24	,	,	PUNCT
gs-3799	302	25	biochemical	biochemical	ADJ
gs-3799	302	26	homeostasis	homeostasis	NOUN
gs-3799	302	27	,	,	PUNCT
gs-3799	302	28	organ	organ	NOUN
gs-3799	302	29	protection	protection	NOUN
gs-3799	302	30	,	,	PUNCT
gs-3799	302	31	and	and	CCONJ
gs-3799	302	32	patient	patient	ADJ
gs-3799	302	33	outcomes	outcome	NOUN
gs-3799	302	34	.	.	PUNCT
gs-3799	303	1	this	this	DET
gs-3799	303	2	section	section	NOUN
gs-3799	303	3	synthesizes	synthesize	VERB
gs-3799	303	4	these	these	DET
gs-3799	303	5	findings	finding	NOUN
gs-3799	303	6	,	,	PUNCT
gs-3799	303	7	highlighting	highlight	VERB
gs-3799	303	8	both	both	CCONJ
gs-3799	303	9	the	the	DET
gs-3799	303	10	measurable	measurable	ADJ
gs-3799	303	11	advancements	advancement	NOUN
gs-3799	303	12	and	and	CCONJ
gs-3799	303	13	unresolved	unresolved	ADJ
gs-3799	303	14	challenges	challenge	NOUN
gs-3799	303	15	.	.	PUNCT
gs-3799	304	1	one	one	NUM
gs-3799	304	2	of	of	ADP
gs-3799	304	3	the	the	DET
gs-3799	304	4	primary	primary	ADJ
gs-3799	304	5	outcomes	outcome	NOUN
gs-3799	304	6	observed	observe	VERB
gs-3799	304	7	in	in	ADP
gs-3799	304	8	closed	closed	ADJ
gs-3799	304	9	-	-	PUNCT
gs-3799	304	10	loop	loop	NOUN
gs-3799	304	11	cpb	cpb	NOUN
gs-3799	304	12	applications	application	NOUN
gs-3799	304	13	is	be	AUX
gs-3799	304	14	the	the	DET
gs-3799	304	15	marked	mark	VERB
gs-3799	304	16	improvement	improvement	NOUN
gs-3799	304	17	in	in	ADP
gs-3799	304	18	hemodynamic	hemodynamic	ADJ
gs-3799	304	19	stability	stability	NOUN
gs-3799	304	20	.	.	PUNCT
gs-3799	305	1	systems	system	NOUN
gs-3799	305	2	utilizing	utilize	VERB
gs-3799	305	3	real	real	ADJ
gs-3799	305	4	-	-	PUNCT
gs-3799	305	5	time	time	NOUN
gs-3799	305	6	feedback	feedback	NOUN
gs-3799	305	7	to	to	PART
gs-3799	305	8	regulate	regulate	VERB
gs-3799	305	9	perfusion	perfusion	NOUN
gs-3799	305	10	flow	flow	NOUN
gs-3799	305	11	rates	rate	NOUN
gs-3799	305	12	and	and	CCONJ
gs-3799	305	13	systemic	systemic	ADJ
gs-3799	305	14	vascular	vascular	ADJ
gs-3799	305	15	resistance	resistance	NOUN
gs-3799	305	16	have	have	AUX
gs-3799	305	17	demonstrated	demonstrate	VERB
gs-3799	305	18	reduced	reduced	ADJ
gs-3799	305	19	variability	variability	NOUN
gs-3799	305	20	in	in	ADP
gs-3799	305	21	mean	mean	ADJ
gs-3799	305	22	arterial	arterial	ADJ
gs-3799	305	23	pressure	pressure	NOUN
gs-3799	305	24	(	(	PUNCT
gs-3799	305	25	map	map	NOUN
gs-3799	305	26	)	)	PUNCT
gs-3799	305	27	,	,	PUNCT
gs-3799	305	28	a	a	DET
gs-3799	305	29	critical	critical	ADJ
gs-3799	305	30	determinant	determinant	NOUN
gs-3799	305	31	of	of	ADP
gs-3799	305	32	organ	organ	NOUN
gs-3799	305	33	perfusion	perfusion	NOUN
gs-3799	305	34	during	during	ADP
gs-3799	305	35	bypass	bypass	NOUN
gs-3799	305	36	.	.	PUNCT
gs-3799	306	1	continuous	continuous	ADJ
gs-3799	306	2	control	control	NOUN
gs-3799	306	3	of	of	ADP
gs-3799	306	4	pump	pump	NOUN
gs-3799	306	5	flow	flow	NOUN
gs-3799	306	6	,	,	PUNCT
gs-3799	306	7	guided	guide	VERB
gs-3799	306	8	by	by	ADP
gs-3799	306	9	arterial	arterial	ADJ
gs-3799	306	10	pressure	pressure	NOUN
gs-3799	306	11	sensors	sensor	NOUN
gs-3799	306	12	and	and	CCONJ
gs-3799	306	13	systemic	systemic	ADJ
gs-3799	306	14	resistance	resistance	NOUN
gs-3799	306	15	estimations	estimation	NOUN
gs-3799	306	16	,	,	PUNCT
gs-3799	306	17	allows	allow	VERB
gs-3799	306	18	for	for	ADP
gs-3799	306	19	more	more	ADV
gs-3799	306	20	consistent	consistent	ADJ
gs-3799	306	21	perfusion	perfusion	NOUN
gs-3799	306	22	pressures	pressure	NOUN
gs-3799	306	23	,	,	PUNCT
gs-3799	306	24	minimizing	minimize	VERB
gs-3799	306	25	periods	period	NOUN
gs-3799	306	26	of	of	ADP
gs-3799	306	27	hypoor	hypoor	ADJ
gs-3799	306	28	hypertension	hypertension	NOUN
gs-3799	306	29	.	.	PUNCT
gs-3799	307	1	studies	study	NOUN
gs-3799	307	2	comparing	compare	VERB
gs-3799	307	3	conventional	conventional	ADJ
gs-3799	307	4	cpb	cpb	NOUN
gs-3799	307	5	to	to	ADP
gs-3799	307	6	closed	close	VERB
gs-3799	307	7	-	-	PUNCT
gs-3799	307	8	loop	loop	NOUN
gs-3799	307	9	systems	system	NOUN
gs-3799	307	10	report	report	VERB
gs-3799	307	11	a	a	DET
gs-3799	307	12	statistically	statistically	ADV
gs-3799	307	13	significant	significant	ADJ
gs-3799	307	14	reduction	reduction	NOUN
gs-3799	307	15	in	in	ADP
gs-3799	307	16	map	map	NOUN
gs-3799	307	17	fluctuations	fluctuation	NOUN
gs-3799	307	18	,	,	PUNCT
gs-3799	307	19	which	which	PRON
gs-3799	307	20	correlates	correlate	VERB
gs-3799	307	21	with	with	ADP
gs-3799	307	22	decreased	decrease	VERB
gs-3799	307	23	intraoperative	intraoperative	ADJ
gs-3799	307	24	vasopressor	vasopressor	NOUN
gs-3799	307	25	requirements	requirement	NOUN
gs-3799	307	26	and	and	CCONJ
gs-3799	307	27	enhanced	enhance	VERB
gs-3799	307	28	tissue	tissue	NOUN
gs-3799	307	29	perfusion	perfusion	NOUN
gs-3799	307	30	metrics	metric	NOUN
gs-3799	307	31	.	.	PUNCT
gs-3799	308	1	metabolic	metabolic	NOUN
gs-3799	308	2	parameters	parameter	NOUN
gs-3799	308	3	such	such	ADJ
gs-3799	308	4	as	as	ADP
gs-3799	308	5	lactate	lactate	NOUN
gs-3799	308	6	clearance	clearance	NOUN
gs-3799	308	7	and	and	CCONJ
gs-3799	308	8	base	base	NOUN
gs-3799	308	9	deficit	deficit	NOUN
gs-3799	308	10	also	also	ADV
gs-3799	308	11	show	show	VERB
gs-3799	308	12	favorable	favorable	ADJ
gs-3799	308	13	trends	trend	NOUN
gs-3799	308	14	in	in	ADP
gs-3799	308	15	patients	patient	NOUN
gs-3799	308	16	supported	support	VERB
gs-3799	308	17	by	by	ADP
gs-3799	308	18	closed	closed	ADJ
gs-3799	308	19	-	-	PUNCT
gs-3799	308	20	loop	loop	NOUN
gs-3799	308	21	systems	system	NOUN
gs-3799	308	22	.	.	PUNCT
gs-3799	309	1	enhanced	enhance	VERB
gs-3799	309	2	delivery	delivery	NOUN
gs-3799	309	3	of	of	ADP
gs-3799	309	4	oxygen	oxygen	NOUN
gs-3799	309	5	,	,	PUNCT
gs-3799	309	6	regulated	regulate	VERB
gs-3799	309	7	in	in	ADP
gs-3799	309	8	real	real	ADJ
gs-3799	309	9	time	time	NOUN
gs-3799	309	10	through	through	ADP
gs-3799	309	11	adjustments	adjustment	NOUN
gs-3799	309	12	in	in	ADP
gs-3799	309	13	flow	flow	NOUN
gs-3799	309	14	rate	rate	NOUN
gs-3799	309	15	and	and	CCONJ
gs-3799	309	16	hematocrit	hematocrit	PROPN
gs-3799	309	17	optimization	optimization	NOUN
gs-3799	309	18	,	,	PUNCT
gs-3799	309	19	leads	lead	VERB
gs-3799	309	20	to	to	ADP
gs-3799	309	21	more	more	ADV
gs-3799	309	22	efficient	efficient	ADJ
gs-3799	309	23	aerobic	aerobic	ADJ
gs-3799	309	24	metabolism	metabolism	NOUN
gs-3799	309	25	.	.	PUNCT
gs-3799	310	1	lactate	lactate	NOUN
gs-3799	310	2	trends	trend	NOUN
gs-3799	310	3	,	,	PUNCT
gs-3799	310	4	often	often	ADV
gs-3799	310	5	used	use	VERB
gs-3799	310	6	as	as	ADP
gs-3799	310	7	surrogate	surrogate	ADJ
gs-3799	310	8	markers	marker	NOUN
gs-3799	310	9	for	for	ADP
gs-3799	310	10	tissue	tissue	NOUN
gs-3799	310	11	hypoxia	hypoxia	NOUN
gs-3799	310	12	,	,	PUNCT
gs-3799	310	13	decline	decline	VERB
gs-3799	310	14	more	more	ADV
gs-3799	310	15	rapidly	rapidly	ADV
gs-3799	310	16	in	in	ADP
gs-3799	310	17	patients	patient	NOUN
gs-3799	310	18	receiving	receive	VERB
gs-3799	310	19	tightly	tightly	ADV
gs-3799	310	20	regulated	regulate	VERB
gs-3799	310	21	perfusion	perfusion	NOUN
gs-3799	310	22	,	,	PUNCT
gs-3799	310	23	especially	especially	ADV
gs-3799	310	24	in	in	ADP
gs-3799	310	25	procedures	procedure	NOUN
gs-3799	310	26	exceeding	exceed	VERB
gs-3799	310	27	two	two	NUM
gs-3799	310	28	hours	hour	NOUN
gs-3799	310	29	.	.	PUNCT
gs-3799	311	1	additionally	additionally	ADV
gs-3799	311	2	,	,	PUNCT
gs-3799	311	3	dynamic	dynamic	ADJ
gs-3799	311	4	hematocrit	hematocrit	NOUN
gs-3799	311	5	control	control	NOUN
gs-3799	311	6	,	,	PUNCT
gs-3799	311	7	whether	whether	SCONJ
gs-3799	311	8	through	through	ADP
gs-3799	311	9	automated	automate	VERB
gs-3799	311	10	ultrafiltration	ultrafiltration	NOUN
gs-3799	311	11	or	or	CCONJ
gs-3799	311	12	transfusion	transfusion	NOUN
gs-3799	311	13	protocols	protocol	NOUN
gs-3799	311	14	,	,	PUNCT
gs-3799	311	15	contributes	contribute	VERB
gs-3799	311	16	to	to	ADP
gs-3799	311	17	improved	improved	ADJ
gs-3799	311	18	oxygen	oxygen	NOUN
gs-3799	311	19	delivery	delivery	NOUN
gs-3799	311	20	indexes	index	NOUN
gs-3799	311	21	and	and	CCONJ
gs-3799	311	22	reduced	reduce	VERB
gs-3799	311	23	need	need	NOUN
gs-3799	311	24	for	for	ADP
gs-3799	311	25	intraoperative	intraoperative	ADJ
gs-3799	311	26	transfusions	transfusion	NOUN
gs-3799	311	27	.	.	PUNCT
gs-3799	312	1	neurologic	neurologic	ADJ
gs-3799	312	2	outcomes	outcome	NOUN
gs-3799	312	3	remain	remain	VERB
gs-3799	312	4	a	a	DET
gs-3799	312	5	key	key	ADJ
gs-3799	312	6	concern	concern	NOUN
gs-3799	312	7	in	in	ADP
gs-3799	312	8	cpb	cpb	NOUN
gs-3799	312	9	procedures	procedure	NOUN
gs-3799	312	10	.	.	PUNCT
gs-3799	313	1	continuous	continuous	ADJ
gs-3799	313	2	monitoring	monitoring	NOUN
gs-3799	313	3	using	use	VERB
gs-3799	313	4	near	near	ADV
gs-3799	313	5	-	-	PUNCT
gs-3799	313	6	infrared	infrared	ADJ
gs-3799	313	7	spectroscopy	spectroscopy	NOUN
gs-3799	313	8	(	(	PUNCT
gs-3799	313	9	nirs	nirs	PROPN
gs-3799	313	10	)	)	PUNCT
gs-3799	313	11	and	and	CCONJ
gs-3799	313	12	real	real	ADJ
gs-3799	313	13	-	-	PUNCT
gs-3799	313	14	time	time	NOUN
gs-3799	313	15	cerebral	cerebral	ADJ
gs-3799	313	16	oxygen	oxygen	NOUN
gs-3799	313	17	saturation	saturation	NOUN
gs-3799	313	18	feedback	feedback	NOUN
gs-3799	313	19	enables	enable	VERB
gs-3799	313	20	targeted	target	VERB
gs-3799	313	21	adjustments	adjustment	NOUN
gs-3799	313	22	in	in	ADP
gs-3799	313	23	pump	pump	NOUN
gs-3799	313	24	flow	flow	NOUN
gs-3799	313	25	and	and	CCONJ
gs-3799	313	26	arterial	arterial	ADJ
gs-3799	313	27	co	co	NOUN
gs-3799	313	28	levels	level	NOUN
gs-3799	313	29	.	.	PUNCT
gs-3799	314	1	several	several	ADJ
gs-3799	314	2	trials	trial	NOUN
gs-3799	314	3	integrating	integrate	VERB
gs-3799	314	4	nirs	nir	NOUN
gs-3799	314	5	into	into	ADP
gs-3799	314	6	closed	closed	ADJ
gs-3799	314	7	-	-	PUNCT
gs-3799	314	8	loop	loop	NOUN
gs-3799	314	9	circuits	circuit	NOUN
gs-3799	314	10	report	report	VERB
gs-3799	314	11	reduced	reduce	VERB
gs-3799	314	12	incidence	incidence	NOUN
gs-3799	314	13	of	of	ADP
gs-3799	314	14	cerebral	cerebral	ADJ
gs-3799	314	15	desaturation	desaturation	NOUN
gs-3799	314	16	events	event	NOUN
gs-3799	314	17	,	,	PUNCT
gs-3799	314	18	a	a	DET
gs-3799	314	19	known	know	VERB
gs-3799	314	20	risk	risk	NOUN
gs-3799	314	21	factor	factor	NOUN
gs-3799	314	22	for	for	ADP
gs-3799	314	23	postoperative	postoperative	ADJ
gs-3799	314	24	cognitive	cognitive	ADJ
gs-3799	314	25	dysfunction	dysfunction	NOUN
gs-3799	314	26	and	and	CCONJ
gs-3799	314	27	stroke	stroke	NOUN
gs-3799	314	28	.	.	PUNCT
gs-3799	315	1	though	though	SCONJ
gs-3799	315	2	long	long	ADJ
gs-3799	315	3	-	-	PUNCT
gs-3799	315	4	term	term	NOUN
gs-3799	315	5	neurocognitive	neurocognitive	ADJ
gs-3799	315	6	outcomes	outcome	NOUN
gs-3799	315	7	require	require	VERB
gs-3799	315	8	extended	extended	ADJ
gs-3799	315	9	follow	follow	NOUN
gs-3799	315	10	-	-	PUNCT
gs-3799	315	11	up	up	NOUN
gs-3799	315	12	,	,	PUNCT
gs-3799	315	13	short	short	ADJ
gs-3799	315	14	-	-	PUNCT
gs-3799	315	15	term	term	NOUN
gs-3799	315	16	improvements	improvement	NOUN
gs-3799	315	17	in	in	ADP
gs-3799	315	18	postoperative	postoperative	ADJ
gs-3799	315	19	delirium	delirium	NOUN
gs-3799	315	20	scores	score	NOUN
gs-3799	315	21	and	and	CCONJ
gs-3799	315	22	faster	fast	ADJ
gs-3799	315	23	awakening	awakening	NOUN
gs-3799	315	24	times	time	NOUN
gs-3799	315	25	have	have	AUX
gs-3799	315	26	been	be	AUX
gs-3799	315	27	documented	document	VERB
gs-3799	315	28	,	,	PUNCT
gs-3799	315	29	particularly	particularly	ADV
gs-3799	315	30	in	in	ADP
gs-3799	315	31	elderly	elderly	ADJ
gs-3799	315	32	patient	patient	ADJ
gs-3799	315	33	subsets	subset	NOUN
gs-3799	315	34	.	.	PUNCT
gs-3799	316	1	inflammatory	inflammatory	ADJ
gs-3799	316	2	modulation	modulation	NOUN
gs-3799	316	3	is	be	AUX
gs-3799	316	4	another	another	DET
gs-3799	316	5	area	area	NOUN
gs-3799	316	6	where	where	SCONJ
gs-3799	316	7	closed	closed	ADJ
gs-3799	316	8	-	-	PUNCT
gs-3799	316	9	loop	loop	NOUN
gs-3799	316	10	systems	system	NOUN
gs-3799	316	11	show	show	VERB
gs-3799	316	12	promise	promise	NOUN
gs-3799	316	13	.	.	PUNCT
gs-3799	317	1	cpb	cpb	PROPN
gs-3799	317	2	is	be	AUX
gs-3799	317	3	known	know	VERB
gs-3799	317	4	to	to	PART
gs-3799	317	5	provoke	provoke	VERB
gs-3799	317	6	a	a	DET
gs-3799	317	7	systemic	systemic	ADJ
gs-3799	317	8	inflammatory	inflammatory	ADJ
gs-3799	317	9	response	response	NOUN
gs-3799	317	10	due	due	ADP
gs-3799	317	11	to	to	ADP
gs-3799	317	12	blood	blood	NOUN
gs-3799	317	13	contact	contact	NOUN
gs-3799	317	14	with	with	ADP
gs-3799	317	15	non	non	ADJ
gs-3799	317	16	-	-	ADJ
gs-3799	317	17	physiologic	physiologic	ADJ
gs-3799	317	18	surfaces	surface	NOUN
gs-3799	317	19	and	and	CCONJ
gs-3799	317	20	ischemia	ischemia	NOUN
gs-3799	317	21	-	-	PUNCT
gs-3799	317	22	reperfusion	reperfusion	NOUN
gs-3799	317	23	injury	injury	NOUN
gs-3799	317	24	.	.	PUNCT
gs-3799	318	1	real	real	ADJ
gs-3799	318	2	-	-	PUNCT
gs-3799	318	3	time	time	NOUN
gs-3799	318	4	cytokine	cytokine	NOUN
gs-3799	318	5	monitoring	monitoring	NOUN
gs-3799	318	6	and	and	CCONJ
gs-3799	318	7	feedback	feedback	NOUN
gs-3799	318	8	-	-	PUNCT
gs-3799	318	9	regulated	regulate	VERB
gs-3799	318	10	infusion	infusion	NOUN
gs-3799	318	11	of	of	ADP
gs-3799	318	12	corticosteroids	corticosteroid	NOUN
gs-3799	318	13	or	or	CCONJ
gs-3799	318	14	anti	anti	ADJ
gs-3799	318	15	-	-	ADJ
gs-3799	318	16	cytokine	cytokine	ADJ
gs-3799	318	17	agents	agent	NOUN
gs-3799	318	18	within	within	ADP
gs-3799	318	19	closed	closed	ADJ
gs-3799	318	20	-	-	PUNCT
gs-3799	318	21	loop	loop	NOUN
gs-3799	318	22	designs	design	NOUN
gs-3799	318	23	allow	allow	VERB
gs-3799	318	24	for	for	ADP
gs-3799	318	25	preemptive	preemptive	ADJ
gs-3799	318	26	georgian	georgian	NOUN
gs-3799	318	27	scientists/	scientists/	NUM
gs-3799	318	28	.	.	PUNCT
gs-3799	319	1	7	7	NUM
gs-3799	319	2	n	n	DET
gs-3799	319	3	2	2	NUM
gs-3799	319	4	,	,	PUNCT
gs-3799	319	5	2025	2025	NUM
gs-3799	319	6	397	397	NUM
gs-3799	319	7	attenuation	attenuation	NOUN
gs-3799	319	8	of	of	ADP
gs-3799	319	9	this	this	DET
gs-3799	319	10	response	response	NOUN
gs-3799	319	11	.	.	PUNCT
gs-3799	320	1	in	in	ADP
gs-3799	320	2	early	early	ADJ
gs-3799	320	3	clinical	clinical	ADJ
gs-3799	320	4	evaluations	evaluation	NOUN
gs-3799	320	5	,	,	PUNCT
gs-3799	320	6	patients	patient	NOUN
gs-3799	320	7	supported	support	VERB
gs-3799	320	8	by	by	ADP
gs-3799	320	9	systems	system	NOUN
gs-3799	320	10	with	with	ADP
gs-3799	320	11	active	active	ADJ
gs-3799	320	12	inflammatory	inflammatory	ADJ
gs-3799	320	13	modulation	modulation	NOUN
gs-3799	320	14	exhibited	exhibit	VERB
gs-3799	320	15	lower	low	ADJ
gs-3799	320	16	postoperative	postoperative	ADJ
gs-3799	320	17	levels	level	NOUN
gs-3799	320	18	of	of	ADP
gs-3799	320	19	il-6	il-6	NUM
gs-3799	320	20	and	and	CCONJ
gs-3799	320	21	tnf	tnf	PROPN
gs-3799	320	22	-	-	PUNCT
gs-3799	320	23	alpha	alpha	NOUN
gs-3799	320	24	,	,	PUNCT
gs-3799	320	25	along	along	ADP
gs-3799	320	26	with	with	ADP
gs-3799	320	27	reduced	reduced	ADJ
gs-3799	320	28	markers	marker	NOUN
gs-3799	320	29	of	of	ADP
gs-3799	320	30	endothelial	endothelial	ADJ
gs-3799	320	31	activation	activation	NOUN
gs-3799	320	32	.	.	PUNCT
gs-3799	321	1	these	these	DET
gs-3799	321	2	changes	change	NOUN
gs-3799	321	3	align	align	VERB
gs-3799	321	4	with	with	ADP
gs-3799	321	5	observed	observe	VERB
gs-3799	321	6	reductions	reduction	NOUN
gs-3799	321	7	in	in	ADP
gs-3799	321	8	postoperative	postoperative	ADJ
gs-3799	321	9	vasoplegia	vasoplegia	NOUN
gs-3799	321	10	and	and	CCONJ
gs-3799	321	11	improved	improve	VERB
gs-3799	321	12	capillary	capillary	ADJ
gs-3799	321	13	leak	leak	NOUN
gs-3799	321	14	profiles	profile	NOUN
gs-3799	321	15	.	.	PUNCT
gs-3799	322	1	the	the	DET
gs-3799	322	2	integration	integration	NOUN
gs-3799	322	3	of	of	ADP
gs-3799	322	4	anticoagulation	anticoagulation	NOUN
gs-3799	322	5	management	management	NOUN
gs-3799	322	6	into	into	ADP
gs-3799	322	7	closed	closed	ADJ
gs-3799	322	8	-	-	PUNCT
gs-3799	322	9	loop	loop	NOUN
gs-3799	322	10	systems	system	NOUN
gs-3799	322	11	presents	present	VERB
gs-3799	322	12	one	one	NUM
gs-3799	322	13	of	of	ADP
gs-3799	322	14	the	the	DET
gs-3799	322	15	most	most	ADV
gs-3799	322	16	complex	complex	ADJ
gs-3799	322	17	but	but	CCONJ
gs-3799	322	18	impactful	impactful	ADJ
gs-3799	322	19	innovations	innovation	NOUN
gs-3799	322	20	.	.	PUNCT
gs-3799	323	1	automated	automate	VERB
gs-3799	323	2	heparin	heparin	ADJ
gs-3799	323	3	titration	titration	NOUN
gs-3799	323	4	protocols	protocol	NOUN
gs-3799	323	5	based	base	VERB
gs-3799	323	6	on	on	ADP
gs-3799	323	7	continuous	continuous	ADJ
gs-3799	323	8	activated	activated	ADJ
gs-3799	323	9	clotting	clotting	NOUN
gs-3799	323	10	time	time	NOUN
gs-3799	323	11	(	(	PUNCT
gs-3799	323	12	act	act	PROPN
gs-3799	323	13	)	)	PUNCT
gs-3799	323	14	or	or	CCONJ
gs-3799	323	15	thromboelastography	thromboelastography	NOUN
gs-3799	323	16	(	(	PUNCT
gs-3799	323	17	teg	teg	NOUN
gs-3799	323	18	)	)	PUNCT
gs-3799	323	19	feedback	feedback	NOUN
gs-3799	323	20	have	have	AUX
gs-3799	323	21	demonstrated	demonstrate	VERB
gs-3799	323	22	superior	superior	ADJ
gs-3799	323	23	anticoagulation	anticoagulation	NOUN
gs-3799	323	24	control	control	NOUN
gs-3799	323	25	,	,	PUNCT
gs-3799	323	26	leading	lead	VERB
gs-3799	323	27	to	to	ADP
gs-3799	323	28	fewer	few	ADJ
gs-3799	323	29	clotting	clot	VERB
gs-3799	323	30	events	event	NOUN
gs-3799	323	31	within	within	ADP
gs-3799	323	32	the	the	DET
gs-3799	323	33	circuit	circuit	NOUN
gs-3799	323	34	and	and	CCONJ
gs-3799	323	35	reduced	reduce	VERB
gs-3799	323	36	postoperative	postoperative	ADJ
gs-3799	323	37	bleeding	bleeding	NOUN
gs-3799	323	38	.	.	PUNCT
gs-3799	324	1	algorithms	algorithm	NOUN
gs-3799	324	2	adjusting	adjust	VERB
gs-3799	324	3	protamine	protamine	NOUN
gs-3799	324	4	dosing	dose	VERB
gs-3799	324	5	in	in	ADP
gs-3799	324	6	real	real	ADJ
gs-3799	324	7	-	-	PUNCT
gs-3799	324	8	time	time	NOUN
gs-3799	324	9	,	,	PUNCT
gs-3799	324	10	based	base	VERB
gs-3799	324	11	on	on	ADP
gs-3799	324	12	measured	measure	VERB
gs-3799	324	13	heparin	heparin	ADJ
gs-3799	324	14	concentrations	concentration	NOUN
gs-3799	324	15	and	and	CCONJ
gs-3799	324	16	patient	patient	NOUN
gs-3799	324	17	-	-	PUNCT
gs-3799	324	18	specific	specific	ADJ
gs-3799	324	19	response	response	NOUN
gs-3799	324	20	profiles	profile	NOUN
gs-3799	324	21	,	,	PUNCT
gs-3799	324	22	offer	offer	VERB
gs-3799	324	23	an	an	DET
gs-3799	324	24	individualized	individualized	ADJ
gs-3799	324	25	reversal	reversal	NOUN
gs-3799	324	26	strategy	strategy	NOUN
gs-3799	324	27	that	that	PRON
gs-3799	324	28	minimizes	minimize	VERB
gs-3799	324	29	the	the	DET
gs-3799	324	30	prothrombotic	prothrombotic	ADJ
gs-3799	324	31	risk	risk	NOUN
gs-3799	324	32	associated	associate	VERB
gs-3799	324	33	with	with	ADP
gs-3799	324	34	incomplete	incomplete	ADJ
gs-3799	324	35	neutralization	neutralization	NOUN
gs-3799	324	36	.	.	PUNCT
gs-3799	325	1	from	from	ADP
gs-3799	325	2	a	a	DET
gs-3799	325	3	pharmacokinetic	pharmacokinetic	ADJ
gs-3799	325	4	standpoint	standpoint	NOUN
gs-3799	325	5	,	,	PUNCT
gs-3799	325	6	closed	closed	ADJ
gs-3799	325	7	-	-	PUNCT
gs-3799	325	8	loop	loop	NOUN
gs-3799	325	9	delivery	delivery	NOUN
gs-3799	325	10	of	of	ADP
gs-3799	325	11	vasoactive	vasoactive	ADJ
gs-3799	325	12	agents	agent	NOUN
gs-3799	325	13	such	such	ADJ
gs-3799	325	14	as	as	ADP
gs-3799	325	15	norepinephrine	norepinephrine	NOUN
gs-3799	325	16	,	,	PUNCT
gs-3799	325	17	phenylephrine	phenylephrine	ADJ
gs-3799	325	18	,	,	PUNCT
gs-3799	325	19	and	and	CCONJ
gs-3799	325	20	epinephrine	epinephrine	NOUN
gs-3799	325	21	in	in	ADP
gs-3799	325	22	response	response	NOUN
gs-3799	325	23	to	to	ADP
gs-3799	325	24	real	real	ADJ
gs-3799	325	25	-	-	PUNCT
gs-3799	325	26	time	time	NOUN
gs-3799	325	27	blood	blood	NOUN
gs-3799	325	28	pressure	pressure	NOUN
gs-3799	325	29	and	and	CCONJ
gs-3799	325	30	systemic	systemic	ADJ
gs-3799	325	31	resistance	resistance	NOUN
gs-3799	325	32	data	datum	NOUN
gs-3799	325	33	has	have	AUX
gs-3799	325	34	led	lead	VERB
gs-3799	325	35	to	to	ADP
gs-3799	325	36	smoother	smooth	ADJ
gs-3799	325	37	hemodynamic	hemodynamic	ADJ
gs-3799	325	38	profiles	profile	NOUN
gs-3799	325	39	and	and	CCONJ
gs-3799	325	40	lower	low	ADJ
gs-3799	325	41	total	total	ADJ
gs-3799	325	42	drug	drug	NOUN
gs-3799	325	43	usage	usage	NOUN
gs-3799	325	44	.	.	PUNCT
gs-3799	326	1	these	these	DET
gs-3799	326	2	systems	system	NOUN
gs-3799	326	3	,	,	PUNCT
gs-3799	326	4	when	when	SCONJ
gs-3799	326	5	compared	compare	VERB
gs-3799	326	6	to	to	ADP
gs-3799	326	7	manual	manual	ADJ
gs-3799	326	8	infusion	infusion	NOUN
gs-3799	326	9	protocols	protocol	NOUN
gs-3799	326	10	,	,	PUNCT
gs-3799	326	11	demonstrate	demonstrate	VERB
gs-3799	326	12	more	more	ADV
gs-3799	326	13	precise	precise	ADJ
gs-3799	326	14	dose	dose	NOUN
gs-3799	326	15	titration	titration	NOUN
gs-3799	326	16	,	,	PUNCT
gs-3799	326	17	reducing	reduce	VERB
gs-3799	326	18	episodes	episode	NOUN
gs-3799	326	19	of	of	ADP
gs-3799	326	20	overcorrection	overcorrection	NOUN
gs-3799	326	21	and	and	CCONJ
gs-3799	326	22	rebound	rebound	NOUN
gs-3799	326	23	hypotension	hypotension	NOUN
gs-3799	326	24	.	.	PUNCT
gs-3799	327	1	additionally	additionally	ADV
gs-3799	327	2	,	,	PUNCT
gs-3799	327	3	early	early	ADJ
gs-3799	327	4	-	-	PUNCT
gs-3799	327	5	stage	stage	NOUN
gs-3799	327	6	trials	trial	NOUN
gs-3799	327	7	of	of	ADP
gs-3799	327	8	closed	closed	ADJ
gs-3799	327	9	-	-	PUNCT
gs-3799	327	10	loop	loop	NOUN
gs-3799	327	11	delivery	delivery	NOUN
gs-3799	327	12	of	of	ADP
gs-3799	327	13	anesthetic	anesthetic	ADJ
gs-3799	327	14	agents	agent	NOUN
gs-3799	327	15	show	show	VERB
gs-3799	327	16	enhanced	enhance	VERB
gs-3799	327	17	control	control	NOUN
gs-3799	327	18	of	of	ADP
gs-3799	327	19	anesthetic	anesthetic	ADJ
gs-3799	327	20	depth	depth	NOUN
gs-3799	327	21	,	,	PUNCT
gs-3799	327	22	reduced	reduce	VERB
gs-3799	327	23	burst	burst	ADJ
gs-3799	327	24	suppression	suppression	NOUN
gs-3799	327	25	on	on	ADP
gs-3799	327	26	eeg	eeg	NOUN
gs-3799	327	27	monitoring	monitoring	NOUN
gs-3799	327	28	,	,	PUNCT
gs-3799	327	29	and	and	CCONJ
gs-3799	327	30	faster	fast	ADJ
gs-3799	327	31	emergence	emergence	NOUN
gs-3799	327	32	from	from	ADP
gs-3799	327	33	anesthesia	anesthesia	PROPN
gs-3799	327	34	.	.	PUNCT
gs-3799	328	1	another	another	DET
gs-3799	328	2	major	major	ADJ
gs-3799	328	3	discussion	discussion	NOUN
gs-3799	328	4	point	point	NOUN
gs-3799	328	5	is	be	AUX
gs-3799	328	6	the	the	DET
gs-3799	328	7	reduction	reduction	NOUN
gs-3799	328	8	in	in	ADP
gs-3799	328	9	perfusion	perfusion	NOUN
gs-3799	328	10	-	-	PUNCT
gs-3799	328	11	related	relate	VERB
gs-3799	328	12	complications	complication	NOUN
gs-3799	328	13	.	.	PUNCT
gs-3799	329	1	renal	renal	ADJ
gs-3799	329	2	injury	injury	PROPN
gs-3799	329	3	,	,	PUNCT
gs-3799	329	4	a	a	DET
gs-3799	329	5	common	common	ADJ
gs-3799	329	6	postoperative	postoperative	ADJ
gs-3799	329	7	complication	complication	NOUN
gs-3799	329	8	,	,	PUNCT
gs-3799	329	9	appears	appear	VERB
gs-3799	329	10	less	less	ADV
gs-3799	329	11	prevalent	prevalent	ADJ
gs-3799	329	12	in	in	ADP
gs-3799	329	13	patients	patient	NOUN
gs-3799	329	14	supported	support	VERB
gs-3799	329	15	by	by	ADP
gs-3799	329	16	closed	closed	ADJ
gs-3799	329	17	-	-	PUNCT
gs-3799	329	18	loop	loop	NOUN
gs-3799	329	19	systems	system	NOUN
gs-3799	329	20	.	.	PUNCT
gs-3799	330	1	the	the	DET
gs-3799	330	2	use	use	NOUN
gs-3799	330	3	of	of	ADP
gs-3799	330	4	automated	automate	VERB
gs-3799	330	5	renal	renal	ADJ
gs-3799	330	6	perfusion	perfusion	NOUN
gs-3799	330	7	monitoring	monitoring	NOUN
gs-3799	330	8	and	and	CCONJ
gs-3799	330	9	ultrafiltration	ultrafiltration	NOUN
gs-3799	330	10	regulation	regulation	NOUN
gs-3799	330	11	based	base	VERB
gs-3799	330	12	on	on	ADP
gs-3799	330	13	serum	serum	NOUN
gs-3799	330	14	creatinine	creatinine	NOUN
gs-3799	330	15	trends	trend	NOUN
gs-3799	330	16	and	and	CCONJ
gs-3799	330	17	urine	urine	NOUN
gs-3799	330	18	output	output	NOUN
gs-3799	330	19	has	have	AUX
gs-3799	330	20	been	be	AUX
gs-3799	330	21	associated	associate	VERB
gs-3799	330	22	with	with	ADP
gs-3799	330	23	a	a	DET
gs-3799	330	24	decrease	decrease	NOUN
gs-3799	330	25	in	in	ADP
gs-3799	330	26	acute	acute	ADJ
gs-3799	330	27	kidney	kidney	NOUN
gs-3799	330	28	injury	injury	NOUN
gs-3799	330	29	(	(	PUNCT
gs-3799	330	30	aki	aki	NOUN
gs-3799	330	31	)	)	PUNCT
gs-3799	330	32	rates	rate	NOUN
gs-3799	330	33	.	.	PUNCT
gs-3799	331	1	similarly	similarly	ADV
gs-3799	331	2	,	,	PUNCT
gs-3799	331	3	hepatic	hepatic	ADJ
gs-3799	331	4	function	function	NOUN
gs-3799	331	5	tests	test	VERB
gs-3799	331	6	postoperatively	postoperatively	ADV
gs-3799	331	7	reveal	reveal	VERB
gs-3799	331	8	lower	low	ADJ
gs-3799	331	9	transaminase	transaminase	NOUN
gs-3799	331	10	elevations	elevation	NOUN
gs-3799	331	11	and	and	CCONJ
gs-3799	331	12	improved	improve	VERB
gs-3799	331	13	synthetic	synthetic	ADJ
gs-3799	331	14	function	function	NOUN
gs-3799	331	15	,	,	PUNCT
gs-3799	331	16	especially	especially	ADV
gs-3799	331	17	in	in	ADP
gs-3799	331	18	longer	long	ADJ
gs-3799	331	19	procedures	procedure	NOUN
gs-3799	331	20	involving	involve	VERB
gs-3799	331	21	high	high	ADJ
gs-3799	331	22	risk	risk	NOUN
gs-3799	331	23	of	of	ADP
gs-3799	331	24	splanchnic	splanchnic	ADJ
gs-3799	331	25	hypoperfusion	hypoperfusion	NOUN
gs-3799	331	26	.	.	PUNCT
gs-3799	332	1	hospital	hospital	NOUN
gs-3799	332	2	outcome	outcome	NOUN
gs-3799	332	3	data	datum	NOUN
gs-3799	332	4	further	far	ADV
gs-3799	332	5	support	support	VERB
gs-3799	332	6	the	the	DET
gs-3799	332	7	efficacy	efficacy	NOUN
gs-3799	332	8	of	of	ADP
gs-3799	332	9	closed	closed	ADJ
gs-3799	332	10	-	-	PUNCT
gs-3799	332	11	loop	loop	NOUN
gs-3799	332	12	cpb	cpb	PROPN
gs-3799	332	13	systems	system	NOUN
gs-3799	332	14	.	.	PUNCT
gs-3799	333	1	reports	report	NOUN
gs-3799	333	2	suggest	suggest	VERB
gs-3799	333	3	a	a	DET
gs-3799	333	4	consistent	consistent	ADJ
gs-3799	333	5	reduction	reduction	NOUN
gs-3799	333	6	in	in	ADP
gs-3799	333	7	icu	icu	PROPN
gs-3799	333	8	length	length	NOUN
gs-3799	333	9	of	of	ADP
gs-3799	333	10	stay	stay	NOUN
gs-3799	333	11	,	,	PUNCT
gs-3799	333	12	need	need	VERB
gs-3799	333	13	for	for	ADP
gs-3799	333	14	mechanical	mechanical	ADJ
gs-3799	333	15	ventilation	ventilation	NOUN
gs-3799	333	16	,	,	PUNCT
gs-3799	333	17	and	and	CCONJ
gs-3799	333	18	overall	overall	ADJ
gs-3799	333	19	hospitalization	hospitalization	NOUN
gs-3799	333	20	duration	duration	NOUN
gs-3799	333	21	.	.	PUNCT
gs-3799	334	1	this	this	PRON
gs-3799	334	2	is	be	AUX
gs-3799	334	3	likely	likely	ADJ
gs-3799	334	4	a	a	DET
gs-3799	334	5	multifactorial	multifactorial	ADJ
gs-3799	334	6	result	result	NOUN
gs-3799	334	7	stemming	stem	VERB
gs-3799	334	8	from	from	ADP
gs-3799	334	9	improved	improved	ADJ
gs-3799	334	10	hemodynamics	hemodynamic	NOUN
gs-3799	334	11	,	,	PUNCT
gs-3799	334	12	decreased	decrease	VERB
gs-3799	334	13	inflammatory	inflammatory	ADJ
gs-3799	334	14	burden	burden	NOUN
gs-3799	334	15	,	,	PUNCT
gs-3799	334	16	fewer	few	ADJ
gs-3799	334	17	transfusions	transfusion	NOUN
gs-3799	334	18	,	,	PUNCT
gs-3799	334	19	and	and	CCONJ
gs-3799	334	20	better	well	ADJ
gs-3799	334	21	organ	organ	NOUN
gs-3799	334	22	function	function	NOUN
gs-3799	334	23	preservation	preservation	NOUN
gs-3799	334	24	.	.	PUNCT
gs-3799	335	1	cost	cost	NOUN
gs-3799	335	2	analyses	analysis	NOUN
gs-3799	335	3	,	,	PUNCT
gs-3799	335	4	while	while	SCONJ
gs-3799	335	5	variable	variable	ADJ
gs-3799	335	6	depending	depend	VERB
gs-3799	335	7	on	on	ADP
gs-3799	335	8	the	the	DET
gs-3799	335	9	extent	extent	NOUN
gs-3799	335	10	of	of	ADP
gs-3799	335	11	system	system	NOUN
gs-3799	335	12	integration	integration	NOUN
gs-3799	335	13	,	,	PUNCT
gs-3799	335	14	tend	tend	VERB
gs-3799	335	15	to	to	PART
gs-3799	335	16	favor	favor	VERB
gs-3799	335	17	closed	closed	ADJ
gs-3799	335	18	-	-	PUNCT
gs-3799	335	19	loop	loop	NOUN
gs-3799	335	20	approaches	approach	NOUN
gs-3799	335	21	in	in	ADP
gs-3799	335	22	the	the	DET
gs-3799	335	23	long	long	ADJ
gs-3799	335	24	term	term	NOUN
gs-3799	335	25	due	due	ADP
gs-3799	335	26	to	to	ADP
gs-3799	335	27	decreased	decrease	VERB
gs-3799	335	28	complication	complication	NOUN
gs-3799	335	29	rates	rate	NOUN
gs-3799	335	30	and	and	CCONJ
gs-3799	335	31	resource	resource	NOUN
gs-3799	335	32	utilization	utilization	NOUN
gs-3799	335	33	.	.	PUNCT
gs-3799	336	1	despite	despite	SCONJ
gs-3799	336	2	these	these	DET
gs-3799	336	3	positive	positive	ADJ
gs-3799	336	4	trends	trend	NOUN
gs-3799	336	5	,	,	PUNCT
gs-3799	336	6	the	the	DET
gs-3799	336	7	discussion	discussion	NOUN
gs-3799	336	8	must	must	AUX
gs-3799	336	9	also	also	ADV
gs-3799	336	10	address	address	VERB
gs-3799	336	11	the	the	DET
gs-3799	336	12	limitations	limitation	NOUN
gs-3799	336	13	encountered	encounter	VERB
gs-3799	336	14	during	during	ADP
gs-3799	336	15	implementation	implementation	NOUN
gs-3799	336	16	.	.	PUNCT
gs-3799	337	1	one	one	NUM
gs-3799	337	2	of	of	ADP
gs-3799	337	3	the	the	DET
gs-3799	337	4	primary	primary	ADJ
gs-3799	337	5	concerns	concern	NOUN
gs-3799	337	6	is	be	AUX
gs-3799	337	7	the	the	DET
gs-3799	337	8	complexity	complexity	NOUN
gs-3799	337	9	of	of	ADP
gs-3799	337	10	system	system	NOUN
gs-3799	337	11	integration	integration	NOUN
gs-3799	337	12	and	and	CCONJ
gs-3799	337	13	the	the	DET
gs-3799	337	14	interoperability	interoperability	NOUN
gs-3799	337	15	of	of	ADP
gs-3799	337	16	monitoring	monitoring	NOUN
gs-3799	337	17	devices	device	NOUN
gs-3799	337	18	from	from	ADP
gs-3799	337	19	different	different	ADJ
gs-3799	337	20	manufacturers	manufacturer	NOUN
gs-3799	337	21	.	.	PUNCT
gs-3799	338	1	inconsistent	inconsistent	ADJ
gs-3799	338	2	communication	communication	PROPN
gs-3799	338	3	protocols	protocol	NOUN
gs-3799	338	4	and	and	CCONJ
gs-3799	338	5	proprietary	proprietary	ADJ
gs-3799	338	6	data	data	NOUN
gs-3799	338	7	formats	format	NOUN
gs-3799	338	8	create	create	VERB
gs-3799	338	9	substantial	substantial	ADJ
gs-3799	338	10	challenges	challenge	NOUN
gs-3799	338	11	in	in	ADP
gs-3799	338	12	achieving	achieve	VERB
gs-3799	338	13	seamless	seamless	ADJ
gs-3799	338	14	data	datum	NOUN
gs-3799	338	15	exchange	exchange	NOUN
gs-3799	338	16	within	within	ADP
gs-3799	338	17	a	a	DET
gs-3799	338	18	unified	unified	ADJ
gs-3799	338	19	control	control	NOUN
gs-3799	338	20	loop	loop	NOUN
gs-3799	338	21	.	.	PUNCT
gs-3799	339	1	efforts	effort	NOUN
gs-3799	339	2	to	to	PART
gs-3799	339	3	standardize	standardize	VERB
gs-3799	339	4	these	these	DET
gs-3799	339	5	platforms	platform	NOUN
gs-3799	339	6	are	be	AUX
gs-3799	339	7	underway	underway	ADJ
gs-3799	339	8	but	but	CCONJ
gs-3799	339	9	remain	remain	VERB
gs-3799	339	10	incomplete	incomplete	ADJ
gs-3799	339	11	,	,	PUNCT
gs-3799	339	12	limiting	limit	VERB
gs-3799	339	13	the	the	DET
gs-3799	339	14	scalability	scalability	NOUN
gs-3799	339	15	of	of	ADP
gs-3799	339	16	current	current	ADJ
gs-3799	339	17	prototypes	prototype	NOUN
gs-3799	339	18	.	.	PUNCT
gs-3799	340	1	algorithm	algorithm	NOUN
gs-3799	340	2	performance	performance	NOUN
gs-3799	340	3	under	under	ADP
gs-3799	340	4	highly	highly	ADV
gs-3799	340	5	variable	variable	ADJ
gs-3799	340	6	clinical	clinical	ADJ
gs-3799	340	7	conditions	condition	NOUN
gs-3799	340	8	also	also	ADV
gs-3799	340	9	warrants	warrant	VERB
gs-3799	340	10	scrutiny	scrutiny	NOUN
gs-3799	340	11	.	.	PUNCT
gs-3799	341	1	while	while	SCONJ
gs-3799	341	2	closed	close	VERB
gs-3799	341	3	-	-	PUNCT
gs-3799	341	4	loop	loop	NOUN
gs-3799	341	5	systems	system	NOUN
gs-3799	341	6	excel	excel	VERB
gs-3799	341	7	under	under	ADP
gs-3799	341	8	stable	stable	ADJ
gs-3799	341	9	conditions	condition	NOUN
gs-3799	341	10	,	,	PUNCT
gs-3799	341	11	abrupt	abrupt	ADJ
gs-3799	341	12	hemodynamic	hemodynamic	ADJ
gs-3799	341	13	shifts	shift	NOUN
gs-3799	341	14	such	such	ADJ
gs-3799	341	15	as	as	ADP
gs-3799	341	16	massive	massive	ADJ
gs-3799	341	17	bleeding	bleeding	NOUN
gs-3799	341	18	,	,	PUNCT
gs-3799	341	19	arrhythmias	arrhythmia	NOUN
gs-3799	341	20	,	,	PUNCT
gs-3799	341	21	or	or	CCONJ
gs-3799	341	22	cardiac	cardiac	ADJ
gs-3799	341	23	arrest	arrest	NOUN
gs-3799	341	24	may	may	AUX
gs-3799	341	25	outpace	outpace	VERB
gs-3799	341	26	the	the	DET
gs-3799	341	27	algorithm	algorithm	NOUN
gs-3799	341	28	's	's	PART
gs-3799	341	29	predictive	predictive	ADJ
gs-3799	341	30	capabilities	capability	NOUN
gs-3799	341	31	.	.	PUNCT
gs-3799	342	1	this	this	PRON
gs-3799	342	2	necessitates	necessitate	VERB
gs-3799	342	3	the	the	DET
gs-3799	342	4	presence	presence	NOUN
gs-3799	342	5	of	of	ADP
gs-3799	342	6	override	override	NOUN
gs-3799	342	7	mechanisms	mechanism	NOUN
gs-3799	342	8	and	and	CCONJ
gs-3799	342	9	clinician	clinician	ADJ
gs-3799	342	10	oversight	oversight	NOUN
gs-3799	342	11	to	to	PART
gs-3799	342	12	ensure	ensure	VERB
gs-3799	342	13	patient	patient	ADJ
gs-3799	342	14	safety	safety	NOUN
gs-3799	342	15	.	.	PUNCT
gs-3799	343	1	georgian	georgian	NOUN
gs-3799	343	2	scientists/	scientists/	NUM
gs-3799	343	3	.	.	PUNCT
gs-3799	344	1	7	7	NUM
gs-3799	344	2	n	n	PRON
gs-3799	344	3	2	2	NUM
gs-3799	344	4	,	,	PUNCT
gs-3799	344	5	2025	2025	NUM
gs-3799	344	6	398	398	NUM
gs-3799	344	7	moreover	moreover	ADV
gs-3799	344	8	,	,	PUNCT
gs-3799	344	9	machine	machine	NOUN
gs-3799	344	10	learning	learning	NOUN
gs-3799	344	11	-	-	PUNCT
gs-3799	344	12	based	base	VERB
gs-3799	344	13	systems	system	NOUN
gs-3799	344	14	require	require	VERB
gs-3799	344	15	extensive	extensive	ADJ
gs-3799	344	16	training	training	NOUN
gs-3799	344	17	datasets	dataset	NOUN
gs-3799	344	18	to	to	PART
gs-3799	344	19	achieve	achieve	VERB
gs-3799	344	20	reliability	reliability	NOUN
gs-3799	344	21	,	,	PUNCT
gs-3799	344	22	and	and	CCONJ
gs-3799	344	23	current	current	ADJ
gs-3799	344	24	datasets	dataset	NOUN
gs-3799	344	25	often	often	ADV
gs-3799	344	26	lack	lack	VERB
gs-3799	344	27	sufficient	sufficient	ADJ
gs-3799	344	28	diversity	diversity	NOUN
gs-3799	344	29	across	across	ADP
gs-3799	344	30	age	age	NOUN
gs-3799	344	31	groups	group	NOUN
gs-3799	344	32	,	,	PUNCT
gs-3799	344	33	comorbidities	comorbiditie	NOUN
gs-3799	344	34	,	,	PUNCT
gs-3799	344	35	and	and	CCONJ
gs-3799	344	36	ethnicities	ethnicity	NOUN
gs-3799	344	37	to	to	PART
gs-3799	344	38	ensure	ensure	VERB
gs-3799	344	39	generalizable	generalizable	ADJ
gs-3799	344	40	performance	performance	NOUN
gs-3799	344	41	.	.	PUNCT
gs-3799	345	1	user	user	NOUN
gs-3799	345	2	trust	trust	PROPN
gs-3799	345	3	and	and	CCONJ
gs-3799	345	4	clinical	clinical	ADJ
gs-3799	345	5	adoption	adoption	NOUN
gs-3799	345	6	represent	represent	VERB
gs-3799	345	7	additional	additional	ADJ
gs-3799	345	8	hurdles	hurdle	NOUN
gs-3799	345	9	.	.	PUNCT
gs-3799	346	1	despite	despite	SCONJ
gs-3799	346	2	evidence	evidence	NOUN
gs-3799	346	3	of	of	ADP
gs-3799	346	4	efficacy	efficacy	NOUN
gs-3799	346	5	,	,	PUNCT
gs-3799	346	6	many	many	ADJ
gs-3799	346	7	clinicians	clinician	NOUN
gs-3799	346	8	remain	remain	VERB
gs-3799	346	9	cautious	cautious	ADJ
gs-3799	346	10	about	about	ADP
gs-3799	346	11	relinquishing	relinquish	VERB
gs-3799	346	12	control	control	NOUN
gs-3799	346	13	to	to	ADP
gs-3799	346	14	automated	automate	VERB
gs-3799	346	15	systems	system	NOUN
gs-3799	346	16	.	.	PUNCT
gs-3799	347	1	this	this	DET
gs-3799	347	2	skepticism	skepticism	NOUN
gs-3799	347	3	is	be	AUX
gs-3799	347	4	compounded	compound	VERB
gs-3799	347	5	by	by	ADP
gs-3799	347	6	a	a	DET
gs-3799	347	7	lack	lack	NOUN
gs-3799	347	8	of	of	ADP
gs-3799	347	9	transparency	transparency	NOUN
gs-3799	347	10	in	in	ADP
gs-3799	347	11	how	how	SCONJ
gs-3799	347	12	some	some	DET
gs-3799	347	13	machine	machine	NOUN
gs-3799	347	14	learning	learn	VERB
gs-3799	347	15	algorithms	algorithm	NOUN
gs-3799	347	16	derive	derive	VERB
gs-3799	347	17	their	their	PRON
gs-3799	347	18	decisions	decision	NOUN
gs-3799	347	19	.	.	PUNCT
gs-3799	348	1	to	to	PART
gs-3799	348	2	address	address	VERB
gs-3799	348	3	this	this	PRON
gs-3799	348	4	,	,	PUNCT
gs-3799	348	5	developers	developer	NOUN
gs-3799	348	6	are	be	AUX
gs-3799	348	7	exploring	explore	VERB
gs-3799	348	8	explainable	explainable	ADJ
gs-3799	348	9	ai	ai	NOUN
gs-3799	348	10	models	model	NOUN
gs-3799	348	11	and	and	CCONJ
gs-3799	348	12	user	user	NOUN
gs-3799	348	13	dashboards	dashboard	NOUN
gs-3799	348	14	that	that	PRON
gs-3799	348	15	visualize	visualize	VERB
gs-3799	348	16	algorithm	algorithm	NOUN
gs-3799	348	17	logic	logic	NOUN
gs-3799	348	18	and	and	CCONJ
gs-3799	348	19	real	real	ADJ
gs-3799	348	20	-	-	PUNCT
gs-3799	348	21	time	time	NOUN
gs-3799	348	22	decision	decision	NOUN
gs-3799	348	23	pathways	pathway	NOUN
gs-3799	348	24	,	,	PUNCT
gs-3799	348	25	helping	help	VERB
gs-3799	348	26	clinicians	clinician	NOUN
gs-3799	348	27	understand	understand	VERB
gs-3799	348	28	and	and	CCONJ
gs-3799	348	29	trust	trust	NOUN
gs-3799	348	30	system	system	NOUN
gs-3799	348	31	behavior	behavior	NOUN
gs-3799	348	32	.	.	PUNCT
gs-3799	349	1	legal	legal	ADJ
gs-3799	349	2	and	and	CCONJ
gs-3799	349	3	ethical	ethical	ADJ
gs-3799	349	4	concerns	concern	NOUN
gs-3799	349	5	further	far	ADV
gs-3799	349	6	complicate	complicate	VERB
gs-3799	349	7	the	the	DET
gs-3799	349	8	clinical	clinical	ADJ
gs-3799	349	9	deployment	deployment	NOUN
gs-3799	349	10	of	of	ADP
gs-3799	349	11	closed	closed	ADJ
gs-3799	349	12	-	-	PUNCT
gs-3799	349	13	loop	loop	NOUN
gs-3799	349	14	systems	system	NOUN
gs-3799	349	15	.	.	PUNCT
gs-3799	350	1	questions	question	NOUN
gs-3799	350	2	regarding	regard	VERB
gs-3799	350	3	liability	liability	NOUN
gs-3799	350	4	in	in	ADP
gs-3799	350	5	the	the	DET
gs-3799	350	6	event	event	NOUN
gs-3799	350	7	of	of	ADP
gs-3799	350	8	an	an	DET
gs-3799	350	9	adverse	adverse	ADJ
gs-3799	350	10	outcome	outcome	NOUN
gs-3799	350	11	—	—	PUNCT
gs-3799	350	12	particularly	particularly	ADV
gs-3799	350	13	when	when	SCONJ
gs-3799	350	14	automation	automation	NOUN
gs-3799	350	15	is	be	AUX
gs-3799	350	16	involved	involve	VERB
gs-3799	350	17	—	—	PUNCT
gs-3799	350	18	remain	remain	VERB
gs-3799	350	19	unresolved	unresolved	ADJ
gs-3799	350	20	.	.	PUNCT
gs-3799	351	1	additionally	additionally	ADV
gs-3799	351	2	,	,	PUNCT
gs-3799	351	3	patient	patient	ADJ
gs-3799	351	4	consent	consent	NOUN
gs-3799	351	5	for	for	ADP
gs-3799	351	6	automated	automate	VERB
gs-3799	351	7	intraoperative	intraoperative	ADJ
gs-3799	351	8	management	management	NOUN
gs-3799	351	9	raises	raise	VERB
gs-3799	351	10	ethical	ethical	ADJ
gs-3799	351	11	considerations	consideration	NOUN
gs-3799	351	12	,	,	PUNCT
gs-3799	351	13	especially	especially	ADV
gs-3799	351	14	in	in	ADP
gs-3799	351	15	emergency	emergency	NOUN
gs-3799	351	16	settings	setting	NOUN
gs-3799	351	17	.	.	PUNCT
gs-3799	352	1	regulatory	regulatory	ADJ
gs-3799	352	2	bodies	body	NOUN
gs-3799	352	3	are	be	AUX
gs-3799	352	4	still	still	ADV
gs-3799	352	5	developing	develop	VERB
gs-3799	352	6	frameworks	framework	NOUN
gs-3799	352	7	to	to	PART
gs-3799	352	8	evaluate	evaluate	VERB
gs-3799	352	9	and	and	CCONJ
gs-3799	352	10	certify	certify	VERB
gs-3799	352	11	such	such	ADJ
gs-3799	352	12	systems	system	NOUN
gs-3799	352	13	,	,	PUNCT
gs-3799	352	14	leading	lead	VERB
gs-3799	352	15	to	to	ADP
gs-3799	352	16	delays	delay	NOUN
gs-3799	352	17	in	in	ADP
gs-3799	352	18	market	market	NOUN
gs-3799	352	19	approval	approval	NOUN
gs-3799	352	20	and	and	CCONJ
gs-3799	352	21	limited	limited	ADJ
gs-3799	352	22	commercial	commercial	ADJ
gs-3799	352	23	availability	availability	NOUN
gs-3799	352	24	.	.	PUNCT
gs-3799	353	1	another	another	DET
gs-3799	353	2	significant	significant	ADJ
gs-3799	353	3	discussion	discussion	NOUN
gs-3799	353	4	point	point	NOUN
gs-3799	353	5	pertains	pertain	VERB
gs-3799	353	6	to	to	ADP
gs-3799	353	7	the	the	DET
gs-3799	353	8	need	need	NOUN
gs-3799	353	9	for	for	ADP
gs-3799	353	10	adaptive	adaptive	ADJ
gs-3799	353	11	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	353	12	models	model	NOUN
gs-3799	353	13	within	within	ADP
gs-3799	353	14	closed	closed	ADJ
gs-3799	353	15	-	-	PUNCT
gs-3799	353	16	loop	loop	NOUN
gs-3799	353	17	designs	design	NOUN
gs-3799	353	18	.	.	PUNCT
gs-3799	354	1	the	the	DET
gs-3799	354	2	dynamic	dynamic	ADJ
gs-3799	354	3	nature	nature	NOUN
gs-3799	354	4	of	of	ADP
gs-3799	354	5	drug	drug	NOUN
gs-3799	354	6	distribution	distribution	NOUN
gs-3799	354	7	during	during	ADP
gs-3799	354	8	cpb	cpb	NOUN
gs-3799	354	9	,	,	PUNCT
gs-3799	354	10	affected	affect	VERB
gs-3799	354	11	by	by	ADP
gs-3799	354	12	temperature	temperature	NOUN
gs-3799	354	13	,	,	PUNCT
gs-3799	354	14	flow	flow	NOUN
gs-3799	354	15	dynamics	dynamic	NOUN
gs-3799	354	16	,	,	PUNCT
gs-3799	354	17	and	and	CCONJ
gs-3799	354	18	metabolic	metabolic	NOUN
gs-3799	354	19	changes	change	NOUN
gs-3799	354	20	,	,	PUNCT
gs-3799	354	21	challenges	challenge	VERB
gs-3799	354	22	the	the	DET
gs-3799	354	23	accuracy	accuracy	NOUN
gs-3799	354	24	of	of	ADP
gs-3799	354	25	current	current	ADJ
gs-3799	354	26	infusion	infusion	NOUN
gs-3799	354	27	algorithms	algorithm	NOUN
gs-3799	354	28	.	.	PUNCT
gs-3799	355	1	ongoing	ongoing	ADJ
gs-3799	355	2	research	research	NOUN
gs-3799	355	3	is	be	AUX
gs-3799	355	4	focused	focus	VERB
gs-3799	355	5	on	on	ADP
gs-3799	355	6	developing	develop	VERB
gs-3799	355	7	physiologically	physiologically	ADV
gs-3799	355	8	based	base	VERB
gs-3799	355	9	pharmacokinetic	pharmacokinetic	ADJ
gs-3799	355	10	models	model	NOUN
gs-3799	355	11	that	that	PRON
gs-3799	355	12	incorporate	incorporate	VERB
gs-3799	355	13	real	real	ADJ
gs-3799	355	14	-	-	PUNCT
gs-3799	355	15	time	time	NOUN
gs-3799	355	16	changes	change	NOUN
gs-3799	355	17	in	in	ADP
gs-3799	355	18	body	body	NOUN
gs-3799	355	19	compartments	compartment	NOUN
gs-3799	355	20	and	and	CCONJ
gs-3799	355	21	drug	drug	NOUN
gs-3799	355	22	metabolism	metabolism	NOUN
gs-3799	355	23	.	.	PUNCT
gs-3799	356	1	these	these	DET
gs-3799	356	2	models	model	NOUN
gs-3799	356	3	will	will	AUX
gs-3799	356	4	be	be	AUX
gs-3799	356	5	essential	essential	ADJ
gs-3799	356	6	for	for	ADP
gs-3799	356	7	optimizing	optimize	VERB
gs-3799	356	8	drug	drug	NOUN
gs-3799	356	9	dosing	dosing	NOUN
gs-3799	356	10	,	,	PUNCT
gs-3799	356	11	particularly	particularly	ADV
gs-3799	356	12	in	in	ADP
gs-3799	356	13	pediatric	pediatric	ADJ
gs-3799	356	14	and	and	CCONJ
gs-3799	356	15	elderly	elderly	ADJ
gs-3799	356	16	populations	population	NOUN
gs-3799	356	17	with	with	ADP
gs-3799	356	18	altered	altered	ADJ
gs-3799	356	19	physiology	physiology	NOUN
gs-3799	356	20	.	.	PUNCT
gs-3799	357	1	research	research	NOUN
gs-3799	357	2	into	into	ADP
gs-3799	357	3	patient	patient	NOUN
gs-3799	357	4	-	-	PUNCT
gs-3799	357	5	specific	specific	ADJ
gs-3799	357	6	closed	closed	ADJ
gs-3799	357	7	-	-	PUNCT
gs-3799	357	8	loop	loop	NOUN
gs-3799	357	9	algorithms	algorithms	NOUN
gs-3799	357	10	is	be	AUX
gs-3799	357	11	also	also	ADV
gs-3799	357	12	gaining	gain	VERB
gs-3799	357	13	momentum	momentum	NOUN
gs-3799	357	14	.	.	PUNCT
gs-3799	358	1	these	these	DET
gs-3799	358	2	systems	system	NOUN
gs-3799	358	3	integrate	integrate	VERB
gs-3799	358	4	preoperative	preoperative	ADJ
gs-3799	358	5	data	datum	NOUN
gs-3799	358	6	such	such	ADJ
gs-3799	358	7	as	as	ADP
gs-3799	358	8	genetic	genetic	ADJ
gs-3799	358	9	markers	marker	NOUN
gs-3799	358	10	,	,	PUNCT
gs-3799	358	11	metabolic	metabolic	NOUN
gs-3799	358	12	profiles	profile	NOUN
gs-3799	358	13	,	,	PUNCT
gs-3799	358	14	and	and	CCONJ
gs-3799	358	15	comorbidity	comorbidity	NOUN
gs-3799	358	16	indexes	index	NOUN
gs-3799	358	17	to	to	PART
gs-3799	358	18	calibrate	calibrate	VERB
gs-3799	358	19	control	control	NOUN
gs-3799	358	20	parameters	parameter	NOUN
gs-3799	358	21	before	before	ADP
gs-3799	358	22	surgery	surgery	NOUN
gs-3799	358	23	.	.	PUNCT
gs-3799	359	1	personalized	personalize	VERB
gs-3799	359	2	algorithms	algorithm	NOUN
gs-3799	359	3	demonstrate	demonstrate	VERB
gs-3799	359	4	improved	improved	ADJ
gs-3799	359	5	performance	performance	NOUN
gs-3799	359	6	in	in	ADP
gs-3799	359	7	predicting	predict	VERB
gs-3799	359	8	hemodynamic	hemodynamic	ADJ
gs-3799	359	9	trends	trend	NOUN
gs-3799	359	10	,	,	PUNCT
gs-3799	359	11	tailoring	tailor	VERB
gs-3799	359	12	drug	drug	NOUN
gs-3799	359	13	dosages	dosage	NOUN
gs-3799	359	14	,	,	PUNCT
gs-3799	359	15	and	and	CCONJ
gs-3799	359	16	anticipating	anticipate	VERB
gs-3799	359	17	adverse	adverse	ADJ
gs-3799	359	18	events	event	NOUN
gs-3799	359	19	.	.	PUNCT
gs-3799	360	1	however	however	ADV
gs-3799	360	2	,	,	PUNCT
gs-3799	360	3	this	this	DET
gs-3799	360	4	level	level	NOUN
gs-3799	360	5	of	of	ADP
gs-3799	360	6	customization	customization	NOUN
gs-3799	360	7	introduces	introduce	VERB
gs-3799	360	8	additional	additional	ADJ
gs-3799	360	9	complexity	complexity	NOUN
gs-3799	360	10	in	in	ADP
gs-3799	360	11	data	data	NOUN
gs-3799	360	12	acquisition	acquisition	NOUN
gs-3799	360	13	,	,	PUNCT
gs-3799	360	14	processing	processing	NOUN
gs-3799	360	15	,	,	PUNCT
gs-3799	360	16	and	and	CCONJ
gs-3799	360	17	regulatory	regulatory	ADJ
gs-3799	360	18	approval	approval	NOUN
gs-3799	360	19	.	.	PUNCT
gs-3799	361	1	in	in	ADP
gs-3799	361	2	terms	term	NOUN
gs-3799	361	3	of	of	ADP
gs-3799	361	4	future	future	ADJ
gs-3799	361	5	research	research	NOUN
gs-3799	361	6	,	,	PUNCT
gs-3799	361	7	large	large	ADJ
gs-3799	361	8	-	-	PUNCT
gs-3799	361	9	scale	scale	NOUN
gs-3799	361	10	multicenter	multicenter	NOUN
gs-3799	361	11	trials	trial	NOUN
gs-3799	361	12	are	be	AUX
gs-3799	361	13	needed	need	VERB
gs-3799	361	14	to	to	PART
gs-3799	361	15	validate	validate	VERB
gs-3799	361	16	the	the	DET
gs-3799	361	17	clinical	clinical	ADJ
gs-3799	361	18	benefits	benefit	NOUN
gs-3799	361	19	of	of	ADP
gs-3799	361	20	closed	closed	ADJ
gs-3799	361	21	-	-	PUNCT
gs-3799	361	22	loop	loop	NOUN
gs-3799	361	23	cpb	cpb	NOUN
gs-3799	361	24	systems	system	NOUN
gs-3799	361	25	across	across	ADP
gs-3799	361	26	diverse	diverse	ADJ
gs-3799	361	27	surgical	surgical	ADJ
gs-3799	361	28	populations	population	NOUN
gs-3799	361	29	.	.	PUNCT
gs-3799	362	1	such	such	ADJ
gs-3799	362	2	studies	study	NOUN
gs-3799	362	3	should	should	AUX
gs-3799	362	4	aim	aim	VERB
gs-3799	362	5	to	to	PART
gs-3799	362	6	standardize	standardize	VERB
gs-3799	362	7	endpoints	endpoint	NOUN
gs-3799	362	8	including	include	VERB
gs-3799	362	9	neurocognitive	neurocognitive	ADJ
gs-3799	362	10	outcomes	outcome	NOUN
gs-3799	362	11	,	,	PUNCT
gs-3799	362	12	renal	renal	ADJ
gs-3799	362	13	function	function	NOUN
gs-3799	362	14	,	,	PUNCT
gs-3799	362	15	inflammatory	inflammatory	ADJ
gs-3799	362	16	markers	marker	NOUN
gs-3799	362	17	,	,	PUNCT
gs-3799	362	18	transfusion	transfusion	NOUN
gs-3799	362	19	requirements	requirement	NOUN
gs-3799	362	20	,	,	PUNCT
gs-3799	362	21	and	and	CCONJ
gs-3799	362	22	long	long	ADJ
gs-3799	362	23	-	-	PUNCT
gs-3799	362	24	term	term	NOUN
gs-3799	362	25	morbidity	morbidity	NOUN
gs-3799	362	26	.	.	PUNCT
gs-3799	363	1	they	they	PRON
gs-3799	363	2	should	should	AUX
gs-3799	363	3	also	also	ADV
gs-3799	363	4	assess	assess	VERB
gs-3799	363	5	cost	cost	NOUN
gs-3799	363	6	-	-	PUNCT
gs-3799	363	7	effectiveness	effectiveness	NOUN
gs-3799	363	8	,	,	PUNCT
gs-3799	363	9	clinician	clinician	NOUN
gs-3799	363	10	workload	workload	NOUN
gs-3799	363	11	,	,	PUNCT
gs-3799	363	12	and	and	CCONJ
gs-3799	363	13	system	system	NOUN
gs-3799	363	14	reliability	reliability	NOUN
gs-3799	363	15	over	over	ADP
gs-3799	363	16	extended	extended	ADJ
gs-3799	363	17	use	use	NOUN
gs-3799	363	18	.	.	PUNCT
gs-3799	364	1	finally	finally	ADV
gs-3799	364	2	,	,	PUNCT
gs-3799	364	3	the	the	DET
gs-3799	364	4	long	long	ADJ
gs-3799	364	5	-	-	PUNCT
gs-3799	364	6	term	term	NOUN
gs-3799	364	7	vision	vision	NOUN
gs-3799	364	8	for	for	ADP
gs-3799	364	9	closed	closed	ADJ
gs-3799	364	10	-	-	PUNCT
gs-3799	364	11	loop	loop	NOUN
gs-3799	364	12	systems	system	NOUN
gs-3799	364	13	encompasses	encompass	VERB
gs-3799	364	14	the	the	DET
gs-3799	364	15	integration	integration	NOUN
gs-3799	364	16	of	of	ADP
gs-3799	364	17	regenerative	regenerative	ADJ
gs-3799	364	18	medicine	medicine	NOUN
gs-3799	364	19	and	and	CCONJ
gs-3799	364	20	real	real	ADJ
gs-3799	364	21	-	-	PUNCT
gs-3799	364	22	time	time	NOUN
gs-3799	364	23	molecular	molecular	ADJ
gs-3799	364	24	diagnostics	diagnostic	NOUN
gs-3799	364	25	.	.	PUNCT
gs-3799	365	1	advanced	advanced	ADJ
gs-3799	365	2	biosensors	biosensor	NOUN
gs-3799	365	3	capable	capable	ADJ
gs-3799	365	4	of	of	ADP
gs-3799	365	5	detecting	detect	VERB
gs-3799	365	6	mitochondrial	mitochondrial	ADJ
gs-3799	365	7	dysfunction	dysfunction	NOUN
gs-3799	365	8	,	,	PUNCT
gs-3799	365	9	oxidative	oxidative	ADJ
gs-3799	365	10	stress	stress	NOUN
gs-3799	365	11	,	,	PUNCT
gs-3799	365	12	and	and	CCONJ
gs-3799	365	13	endothelial	endothelial	ADJ
gs-3799	365	14	activation	activation	NOUN
gs-3799	365	15	in	in	ADP
gs-3799	365	16	real	real	ADJ
gs-3799	365	17	time	time	NOUN
gs-3799	365	18	could	could	AUX
gs-3799	365	19	inform	inform	VERB
gs-3799	365	20	both	both	DET
gs-3799	365	21	perfusion	perfusion	NOUN
gs-3799	365	22	strategies	strategy	NOUN
gs-3799	365	23	and	and	CCONJ
gs-3799	365	24	drug	drug	NOUN
gs-3799	365	25	delivery	delivery	NOUN
gs-3799	365	26	.	.	PUNCT
gs-3799	366	1	likewise	likewise	ADV
gs-3799	366	2	,	,	PUNCT
gs-3799	366	3	the	the	DET
gs-3799	366	4	potential	potential	NOUN
gs-3799	366	5	to	to	PART
gs-3799	366	6	integrate	integrate	VERB
gs-3799	366	7	extracorporeal	extracorporeal	NOUN
gs-3799	366	8	therapies	therapy	NOUN
gs-3799	366	9	such	such	ADJ
gs-3799	366	10	as	as	ADP
gs-3799	366	11	hemoadsorption	hemoadsorption	NOUN
gs-3799	366	12	,	,	PUNCT
gs-3799	366	13	dialysis	dialysis	NOUN
gs-3799	366	14	,	,	PUNCT
gs-3799	366	15	and	and	CCONJ
gs-3799	366	16	targeted	target	VERB
gs-3799	366	17	drug	drug	NOUN
gs-3799	366	18	delivery	delivery	NOUN
gs-3799	366	19	into	into	ADP
gs-3799	366	20	closed	closed	ADJ
gs-3799	366	21	-	-	PUNCT
gs-3799	366	22	loop	loop	NOUN
gs-3799	366	23	frameworks	framework	NOUN
gs-3799	366	24	opens	open	VERB
gs-3799	366	25	the	the	DET
gs-3799	366	26	door	door	NOUN
gs-3799	366	27	to	to	ADP
gs-3799	366	28	broader	broad	ADJ
gs-3799	366	29	perioperative	perioperative	ADJ
gs-3799	366	30	applications	application	NOUN
gs-3799	366	31	.	.	PUNCT
gs-3799	367	1	closed	close	VERB
gs-3799	367	2	-	-	PUNCT
gs-3799	367	3	loop	loop	NOUN
gs-3799	367	4	cpb	cpb	PROPN
gs-3799	367	5	systems	system	NOUN
gs-3799	367	6	represent	represent	VERB
gs-3799	367	7	a	a	DET
gs-3799	367	8	major	major	ADJ
gs-3799	367	9	technological	technological	ADJ
gs-3799	367	10	and	and	CCONJ
gs-3799	367	11	clinical	clinical	ADJ
gs-3799	367	12	evolution	evolution	NOUN
gs-3799	367	13	in	in	ADP
gs-3799	367	14	extracorporeal	extracorporeal	NOUN
gs-3799	367	15	circulation	circulation	NOUN
gs-3799	367	16	.	.	PUNCT
gs-3799	368	1	their	their	PRON
gs-3799	368	2	ability	ability	NOUN
gs-3799	368	3	to	to	PART
gs-3799	368	4	regulate	regulate	VERB
gs-3799	368	5	physiologic	physiologic	ADJ
gs-3799	368	6	parameters	parameter	NOUN
gs-3799	368	7	,	,	PUNCT
gs-3799	368	8	deliver	deliver	VERB
gs-3799	368	9	personalized	personalize	VERB
gs-3799	368	10	georgian	georgian	NOUN
gs-3799	368	11	scientists/	scientists/	NUM
gs-3799	368	12	.	.	PUNCT
gs-3799	369	1	7	7	NUM
gs-3799	369	2	n	n	DET
gs-3799	369	3	2	2	NUM
gs-3799	369	4	,	,	PUNCT
gs-3799	369	5	2025	2025	NUM
gs-3799	369	6	399	399	NUM
gs-3799	369	7	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	369	8	,	,	PUNCT
gs-3799	369	9	and	and	CCONJ
gs-3799	369	10	adapt	adapt	VERB
gs-3799	369	11	to	to	ADP
gs-3799	369	12	dynamic	dynamic	ADJ
gs-3799	369	13	intraoperative	intraoperative	ADJ
gs-3799	369	14	changes	change	NOUN
gs-3799	369	15	holds	hold	VERB
gs-3799	369	16	great	great	ADJ
gs-3799	369	17	promise	promise	NOUN
gs-3799	369	18	for	for	ADP
gs-3799	369	19	enhancing	enhance	VERB
gs-3799	369	20	patient	patient	ADJ
gs-3799	369	21	safety	safety	NOUN
gs-3799	369	22	and	and	CCONJ
gs-3799	369	23	surgical	surgical	ADJ
gs-3799	369	24	outcomes	outcome	NOUN
gs-3799	369	25	.	.	PUNCT
gs-3799	370	1	while	while	SCONJ
gs-3799	370	2	technical	technical	ADJ
gs-3799	370	3	,	,	PUNCT
gs-3799	370	4	ethical	ethical	ADJ
gs-3799	370	5	,	,	PUNCT
gs-3799	370	6	and	and	CCONJ
gs-3799	370	7	regulatory	regulatory	ADJ
gs-3799	370	8	challenges	challenge	NOUN
gs-3799	370	9	remain	remain	VERB
gs-3799	370	10	,	,	PUNCT
gs-3799	370	11	the	the	DET
gs-3799	370	12	cumulative	cumulative	ADJ
gs-3799	370	13	data	datum	NOUN
gs-3799	370	14	support	support	VERB
gs-3799	370	15	continued	continue	VERB
gs-3799	370	16	investment	investment	NOUN
gs-3799	370	17	in	in	ADP
gs-3799	370	18	research	research	NOUN
gs-3799	370	19	,	,	PUNCT
gs-3799	370	20	development	development	NOUN
gs-3799	370	21	,	,	PUNCT
gs-3799	370	22	and	and	CCONJ
gs-3799	370	23	clinical	clinical	ADJ
gs-3799	370	24	integration	integration	NOUN
gs-3799	370	25	of	of	ADP
gs-3799	370	26	these	these	DET
gs-3799	370	27	intelligent	intelligent	ADJ
gs-3799	370	28	systems	system	NOUN
gs-3799	370	29	.	.	PUNCT
gs-3799	371	1	as	as	SCONJ
gs-3799	371	2	they	they	PRON
gs-3799	371	3	mature	mature	VERB
gs-3799	371	4	,	,	PUNCT
gs-3799	371	5	closed	closed	ADJ
gs-3799	371	6	-	-	PUNCT
gs-3799	371	7	loop	loop	NOUN
gs-3799	371	8	systems	system	NOUN
gs-3799	371	9	will	will	AUX
gs-3799	371	10	likely	likely	ADV
gs-3799	371	11	redefine	redefine	VERB
gs-3799	371	12	standards	standard	NOUN
gs-3799	371	13	of	of	ADP
gs-3799	371	14	care	care	NOUN
gs-3799	371	15	,	,	PUNCT
gs-3799	371	16	shifting	shift	VERB
gs-3799	371	17	cardiac	cardiac	ADJ
gs-3799	371	18	surgery	surgery	NOUN
gs-3799	371	19	toward	toward	ADP
gs-3799	371	20	a	a	DET
gs-3799	371	21	more	more	ADV
gs-3799	371	22	predictive	predictive	ADJ
gs-3799	371	23	,	,	PUNCT
gs-3799	371	24	precise	precise	ADJ
gs-3799	371	25	,	,	PUNCT
gs-3799	371	26	and	and	CCONJ
gs-3799	371	27	personalized	personalized	ADJ
gs-3799	371	28	paradigm	paradigm	NOUN
gs-3799	371	29	.	.	PUNCT
gs-3799	372	1	the	the	DET
gs-3799	372	2	progression	progression	NOUN
gs-3799	372	3	of	of	ADP
gs-3799	372	4	closed	closed	ADJ
gs-3799	372	5	-	-	PUNCT
gs-3799	372	6	loop	loop	NOUN
gs-3799	372	7	cpb	cpb	NOUN
gs-3799	372	8	systems	system	NOUN
gs-3799	372	9	into	into	ADP
gs-3799	372	10	broader	broad	ADJ
gs-3799	372	11	clinical	clinical	ADJ
gs-3799	372	12	use	use	NOUN
gs-3799	372	13	requires	require	VERB
gs-3799	372	14	not	not	PART
gs-3799	372	15	only	only	ADV
gs-3799	372	16	an	an	DET
gs-3799	372	17	evaluation	evaluation	NOUN
gs-3799	372	18	of	of	ADP
gs-3799	372	19	system	system	NOUN
gs-3799	372	20	performance	performance	NOUN
gs-3799	372	21	under	under	ADP
gs-3799	372	22	controlled	control	VERB
gs-3799	372	23	conditions	condition	NOUN
gs-3799	372	24	but	but	CCONJ
gs-3799	372	25	also	also	ADV
gs-3799	372	26	a	a	DET
gs-3799	372	27	thorough	thorough	ADJ
gs-3799	372	28	understanding	understanding	NOUN
gs-3799	372	29	of	of	ADP
gs-3799	372	30	variability	variability	NOUN
gs-3799	372	31	across	across	ADP
gs-3799	372	32	patient	patient	ADJ
gs-3799	372	33	populations	population	NOUN
gs-3799	372	34	,	,	PUNCT
gs-3799	372	35	surgical	surgical	ADJ
gs-3799	372	36	contexts	contexts	NOUN
gs-3799	372	37	,	,	PUNCT
gs-3799	372	38	and	and	CCONJ
gs-3799	372	39	institutional	institutional	ADJ
gs-3799	372	40	capabilities	capability	NOUN
gs-3799	372	41	.	.	PUNCT
gs-3799	373	1	this	this	DET
gs-3799	373	2	extended	extended	ADJ
gs-3799	373	3	discussion	discussion	NOUN
gs-3799	373	4	continues	continue	VERB
gs-3799	373	5	to	to	PART
gs-3799	373	6	unravel	unravel	VERB
gs-3799	373	7	the	the	DET
gs-3799	373	8	nuanced	nuanced	ADJ
gs-3799	373	9	implications	implication	NOUN
gs-3799	373	10	of	of	ADP
gs-3799	373	11	this	this	DET
gs-3799	373	12	technology	technology	NOUN
gs-3799	373	13	while	while	SCONJ
gs-3799	373	14	addressing	address	VERB
gs-3799	373	15	emergent	emergent	ADJ
gs-3799	373	16	trends	trend	NOUN
gs-3799	373	17	and	and	CCONJ
gs-3799	373	18	uncharted	uncharted	ADJ
gs-3799	373	19	domains	domain	NOUN
gs-3799	373	20	.	.	PUNCT
gs-3799	374	1	one	one	NUM
gs-3799	374	2	of	of	ADP
gs-3799	374	3	the	the	DET
gs-3799	374	4	most	most	ADV
gs-3799	374	5	compelling	compelling	ADJ
gs-3799	374	6	areas	area	NOUN
gs-3799	374	7	of	of	ADP
gs-3799	374	8	exploration	exploration	NOUN
gs-3799	374	9	is	be	AUX
gs-3799	374	10	the	the	DET
gs-3799	374	11	stratification	stratification	NOUN
gs-3799	374	12	of	of	ADP
gs-3799	374	13	patient	patient	ADJ
gs-3799	374	14	populations	population	NOUN
gs-3799	374	15	based	base	VERB
gs-3799	374	16	on	on	ADP
gs-3799	374	17	preoperative	preoperative	ADJ
gs-3799	374	18	risk	risk	NOUN
gs-3799	374	19	profiles	profile	NOUN
gs-3799	374	20	and	and	CCONJ
gs-3799	374	21	comorbid	comorbid	NOUN
gs-3799	374	22	states	state	NOUN
gs-3799	374	23	.	.	PUNCT
gs-3799	375	1	closed	close	VERB
gs-3799	375	2	-	-	PUNCT
gs-3799	375	3	loop	loop	NOUN
gs-3799	375	4	systems	system	NOUN
gs-3799	375	5	show	show	VERB
gs-3799	375	6	differentiated	differentiated	ADJ
gs-3799	375	7	benefits	benefit	NOUN
gs-3799	375	8	in	in	ADP
gs-3799	375	9	high	high	ADJ
gs-3799	375	10	-	-	PUNCT
gs-3799	375	11	risk	risk	NOUN
gs-3799	375	12	groups	group	NOUN
gs-3799	375	13	,	,	PUNCT
gs-3799	375	14	particularly	particularly	ADV
gs-3799	375	15	in	in	ADP
gs-3799	375	16	patients	patient	NOUN
gs-3799	375	17	with	with	ADP
gs-3799	375	18	preexisting	preexist	VERB
gs-3799	375	19	cardiovascular	cardiovascular	ADJ
gs-3799	375	20	instability	instability	NOUN
gs-3799	375	21	,	,	PUNCT
gs-3799	375	22	renal	renal	ADJ
gs-3799	375	23	dysfunction	dysfunction	NOUN
gs-3799	375	24	,	,	PUNCT
gs-3799	375	25	or	or	CCONJ
gs-3799	375	26	cerebrovascular	cerebrovascular	ADJ
gs-3799	375	27	disease	disease	NOUN
gs-3799	375	28	.	.	PUNCT
gs-3799	376	1	in	in	ADP
gs-3799	376	2	such	such	ADJ
gs-3799	376	3	cohorts	cohort	NOUN
gs-3799	376	4	,	,	PUNCT
gs-3799	376	5	the	the	DET
gs-3799	376	6	margin	margin	NOUN
gs-3799	376	7	for	for	ADP
gs-3799	376	8	hemodynamic	hemodynamic	ADJ
gs-3799	376	9	deviation	deviation	NOUN
gs-3799	376	10	is	be	AUX
gs-3799	376	11	minimal	minimal	ADJ
gs-3799	376	12	,	,	PUNCT
gs-3799	376	13	and	and	CCONJ
gs-3799	376	14	the	the	DET
gs-3799	376	15	ability	ability	NOUN
gs-3799	376	16	of	of	ADP
gs-3799	376	17	closed	closed	ADJ
gs-3799	376	18	-	-	PUNCT
gs-3799	376	19	loop	loop	NOUN
gs-3799	376	20	algorithms	algorithm	NOUN
gs-3799	376	21	to	to	PART
gs-3799	376	22	maintain	maintain	VERB
gs-3799	376	23	steady	steady	ADJ
gs-3799	376	24	-	-	PUNCT
gs-3799	376	25	state	state	NOUN
gs-3799	376	26	perfusion	perfusion	NOUN
gs-3799	376	27	variables	variable	NOUN
gs-3799	376	28	becomes	become	VERB
gs-3799	376	29	clinically	clinically	ADV
gs-3799	376	30	decisive	decisive	ADJ
gs-3799	376	31	.	.	PUNCT
gs-3799	377	1	for	for	ADP
gs-3799	377	2	instance	instance	NOUN
gs-3799	377	3	,	,	PUNCT
gs-3799	377	4	patients	patient	NOUN
gs-3799	377	5	with	with	ADP
gs-3799	377	6	compromised	compromised	ADJ
gs-3799	377	7	cerebral	cerebral	ADJ
gs-3799	377	8	autoregulation	autoregulation	NOUN
gs-3799	377	9	benefit	benefit	NOUN
gs-3799	377	10	significantly	significantly	ADV
gs-3799	377	11	from	from	ADP
gs-3799	377	12	tight	tight	ADJ
gs-3799	377	13	control	control	NOUN
gs-3799	377	14	of	of	ADP
gs-3799	377	15	carbon	carbon	NOUN
gs-3799	377	16	dioxide	dioxide	NOUN
gs-3799	377	17	levels	level	NOUN
gs-3799	377	18	and	and	CCONJ
gs-3799	377	19	cerebral	cerebral	ADJ
gs-3799	377	20	oxygen	oxygen	NOUN
gs-3799	377	21	saturation	saturation	NOUN
gs-3799	377	22	,	,	PUNCT
gs-3799	377	23	both	both	PRON
gs-3799	377	24	of	of	ADP
gs-3799	377	25	which	which	PRON
gs-3799	377	26	are	be	AUX
gs-3799	377	27	now	now	ADV
gs-3799	377	28	incorporated	incorporate	VERB
gs-3799	377	29	into	into	ADP
gs-3799	377	30	intelligent	intelligent	ADJ
gs-3799	377	31	perfusion	perfusion	NOUN
gs-3799	377	32	systems	system	NOUN
gs-3799	377	33	.	.	PUNCT
gs-3799	378	1	these	these	DET
gs-3799	378	2	findings	finding	NOUN
gs-3799	378	3	suggest	suggest	VERB
gs-3799	378	4	a	a	DET
gs-3799	378	5	future	future	ADJ
gs-3799	378	6	model	model	NOUN
gs-3799	378	7	of	of	ADP
gs-3799	378	8	risk	risk	NOUN
gs-3799	378	9	-	-	PUNCT
gs-3799	378	10	adaptive	adaptive	ADJ
gs-3799	378	11	cpb	cpb	PROPN
gs-3799	378	12	control	control	PROPN
gs-3799	378	13	wherein	wherein	SCONJ
gs-3799	378	14	algorithmic	algorithmic	ADJ
gs-3799	378	15	intensity	intensity	NOUN
gs-3799	378	16	is	be	AUX
gs-3799	378	17	matched	match	VERB
gs-3799	378	18	to	to	ADP
gs-3799	378	19	patient	patient	NOUN
gs-3799	378	20	-	-	PUNCT
gs-3799	378	21	specific	specific	ADJ
gs-3799	378	22	vulnerability	vulnerability	NOUN
gs-3799	378	23	,	,	PUNCT
gs-3799	378	24	enhancing	enhance	VERB
gs-3799	378	25	safety	safety	NOUN
gs-3799	378	26	while	while	SCONJ
gs-3799	378	27	conserving	conserve	VERB
gs-3799	378	28	resources	resource	NOUN
gs-3799	378	29	in	in	ADP
gs-3799	378	30	lower	low	ADJ
gs-3799	378	31	-	-	PUNCT
gs-3799	378	32	risk	risk	NOUN
gs-3799	378	33	cases	case	NOUN
gs-3799	378	34	.	.	PUNCT
gs-3799	379	1	the	the	DET
gs-3799	379	2	systematic	systematic	ADJ
gs-3799	379	3	analysis	analysis	NOUN
gs-3799	379	4	elucidates	elucidate	VERB
gs-3799	379	5	that	that	PRON
gs-3799	379	6	closed	close	VERB
gs-3799	379	7	-	-	PUNCT
gs-3799	379	8	loop	loop	NOUN
gs-3799	379	9	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	379	10	bypass	bypass	NOUN
gs-3799	379	11	(	(	PUNCT
gs-3799	379	12	cpb	cpb	NOUN
gs-3799	379	13	)	)	PUNCT
gs-3799	379	14	systems	system	NOUN
gs-3799	379	15	represent	represent	VERB
gs-3799	379	16	a	a	DET
gs-3799	379	17	transformative	transformative	ADJ
gs-3799	379	18	convergence	convergence	NOUN
gs-3799	379	19	of	of	ADP
gs-3799	379	20	real	real	ADJ
gs-3799	379	21	-	-	PUNCT
gs-3799	379	22	time	time	NOUN
gs-3799	379	23	physiological	physiological	ADJ
gs-3799	379	24	monitoring	monitoring	NOUN
gs-3799	379	25	,	,	PUNCT
gs-3799	379	26	algorithmic	algorithmic	ADJ
gs-3799	379	27	control	control	NOUN
gs-3799	379	28	,	,	PUNCT
gs-3799	379	29	and	and	CCONJ
gs-3799	379	30	automated	automate	VERB
gs-3799	379	31	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	379	32	delivery	delivery	NOUN
gs-3799	379	33	.	.	PUNCT
gs-3799	380	1	the	the	DET
gs-3799	380	2	integration	integration	NOUN
gs-3799	380	3	of	of	ADP
gs-3799	380	4	advanced	advanced	ADJ
gs-3799	380	5	sensor	sensor	NOUN
gs-3799	380	6	technologies	technology	NOUN
gs-3799	380	7	—	—	PUNCT
gs-3799	380	8	enabling	enable	VERB
gs-3799	380	9	continuous	continuous	ADJ
gs-3799	380	10	assessment	assessment	NOUN
gs-3799	380	11	of	of	ADP
gs-3799	380	12	hemodynamics	hemodynamic	NOUN
gs-3799	380	13	,	,	PUNCT
gs-3799	380	14	anticoagulation	anticoagulation	NOUN
gs-3799	380	15	,	,	PUNCT
gs-3799	380	16	and	and	CCONJ
gs-3799	380	17	inflammatory	inflammatory	ADJ
gs-3799	380	18	biomarkers	biomarker	NOUN
gs-3799	380	19	—	—	PUNCT
gs-3799	380	20	with	with	ADP
gs-3799	380	21	adaptive	adaptive	ADJ
gs-3799	380	22	control	control	NOUN
gs-3799	380	23	architectures	architecture	NOUN
gs-3799	380	24	facilitates	facilitate	VERB
gs-3799	380	25	precision	precision	NOUN
gs-3799	380	26	perfusion	perfusion	NOUN
gs-3799	380	27	management	management	NOUN
gs-3799	380	28	unattainable	unattainable	ADJ
gs-3799	380	29	through	through	ADP
gs-3799	380	30	conventional	conventional	ADJ
gs-3799	380	31	open	open	ADJ
gs-3799	380	32	-	-	PUNCT
gs-3799	380	33	loop	loop	NOUN
gs-3799	380	34	approaches	approach	NOUN
gs-3799	380	35	.	.	PUNCT
gs-3799	381	1	crucially	crucially	ADV
gs-3799	381	2	,	,	PUNCT
gs-3799	381	3	automated	automate	VERB
gs-3799	381	4	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	381	5	administration	administration	NOUN
gs-3799	381	6	,	,	PUNCT
gs-3799	381	7	particularly	particularly	ADV
gs-3799	381	8	heparin	heparin	NOUN
gs-3799	381	9	-	-	PUNCT
gs-3799	381	10	protamine	protamine	NOUN
gs-3799	381	11	titration	titration	NOUN
gs-3799	381	12	,	,	PUNCT
gs-3799	381	13	demonstrates	demonstrate	VERB
gs-3799	381	14	significantly	significantly	ADV
gs-3799	381	15	enhanced	enhance	VERB
gs-3799	381	16	therapeutic	therapeutic	ADJ
gs-3799	381	17	stability	stability	NOUN
gs-3799	381	18	,	,	PUNCT
gs-3799	381	19	reducing	reduce	VERB
gs-3799	381	20	thrombotic	thrombotic	ADJ
gs-3799	381	21	and	and	CCONJ
gs-3799	381	22	hemorrhagic	hemorrhagic	ADJ
gs-3799	381	23	complications	complication	NOUN
gs-3799	381	24	by	by	ADP
gs-3799	381	25	maintaining	maintain	VERB
gs-3799	381	26	tighter	tight	ADJ
gs-3799	381	27	physiological	physiological	ADJ
gs-3799	381	28	parameters	parameter	NOUN
gs-3799	381	29	.	.	PUNCT
gs-3799	382	1	these	these	DET
gs-3799	382	2	technological	technological	ADJ
gs-3799	382	3	synergies	synergy	NOUN
gs-3799	382	4	substantiate	substantiate	VERB
gs-3799	382	5	the	the	DET
gs-3799	382	6	potential	potential	NOUN
gs-3799	382	7	for	for	ADP
gs-3799	382	8	closed	closed	ADJ
gs-3799	382	9	-	-	PUNCT
gs-3799	382	10	loop	loop	NOUN
gs-3799	382	11	systems	system	NOUN
gs-3799	382	12	to	to	PART
gs-3799	382	13	mitigate	mitigate	VERB
gs-3799	382	14	human	human	ADJ
gs-3799	382	15	cognitive	cognitive	ADJ
gs-3799	382	16	limitations	limitation	NOUN
gs-3799	382	17	,	,	PUNCT
gs-3799	382	18	minimize	minimize	VERB
gs-3799	382	19	practice	practice	NOUN
gs-3799	382	20	variability	variability	NOUN
gs-3799	382	21	,	,	PUNCT
gs-3799	382	22	and	and	CCONJ
gs-3799	382	23	establish	establish	VERB
gs-3799	382	24	new	new	ADJ
gs-3799	382	25	benchmarks	benchmark	NOUN
gs-3799	382	26	for	for	ADP
gs-3799	382	27	procedural	procedural	ADJ
gs-3799	382	28	safety	safety	NOUN
gs-3799	382	29	.	.	PUNCT
gs-3799	383	1	the	the	DET
gs-3799	383	2	clinical	clinical	ADJ
gs-3799	383	3	outcomes	outcome	NOUN
gs-3799	383	4	observed	observe	VERB
gs-3799	383	5	,	,	PUNCT
gs-3799	383	6	however	however	ADV
gs-3799	383	7	,	,	PUNCT
gs-3799	383	8	reveal	reveal	VERB
gs-3799	383	9	nuanced	nuanced	ADJ
gs-3799	383	10	implications	implication	NOUN
gs-3799	383	11	.	.	PUNCT
gs-3799	384	1	while	while	SCONJ
gs-3799	384	2	hemodynamic	hemodynamic	ADJ
gs-3799	384	3	stability	stability	NOUN
gs-3799	384	4	and	and	CCONJ
gs-3799	384	5	organ	organ	NOUN
gs-3799	384	6	protection	protection	NOUN
gs-3799	384	7	metrics	metric	NOUN
gs-3799	384	8	consistently	consistently	ADV
gs-3799	384	9	improve	improve	VERB
gs-3799	384	10	with	with	ADP
gs-3799	384	11	closed	closed	ADJ
gs-3799	384	12	-	-	PUNCT
gs-3799	384	13	loop	loop	NOUN
gs-3799	384	14	adoption	adoption	NOUN
gs-3799	384	15	,	,	PUNCT
gs-3799	384	16	evidence	evidence	NOUN
gs-3799	384	17	for	for	ADP
gs-3799	384	18	mortality	mortality	NOUN
gs-3799	384	19	reduction	reduction	NOUN
gs-3799	384	20	or	or	CCONJ
gs-3799	384	21	long	long	ADJ
gs-3799	384	22	-	-	PUNCT
gs-3799	384	23	term	term	NOUN
gs-3799	384	24	neurocognitive	neurocognitive	ADJ
gs-3799	384	25	benefits	benefit	NOUN
gs-3799	384	26	remains	remain	VERB
gs-3799	384	27	emergent	emergent	ADJ
gs-3799	384	28	.	.	PUNCT
gs-3799	385	1	this	this	DET
gs-3799	385	2	discrepancy	discrepancy	NOUN
gs-3799	385	3	underscores	underscore	VERB
gs-3799	385	4	a	a	DET
gs-3799	385	5	critical	critical	ADJ
gs-3799	385	6	insight	insight	NOUN
gs-3799	385	7	:	:	PUNCT
gs-3799	385	8	closed	close	VERB
gs-3799	385	9	-	-	PUNCT
gs-3799	385	10	loop	loop	NOUN
gs-3799	385	11	efficacy	efficacy	NOUN
gs-3799	385	12	is	be	AUX
gs-3799	385	13	most	most	ADV
gs-3799	385	14	pronounced	pronounce	VERB
gs-3799	385	15	in	in	ADP
gs-3799	385	16	modulating	modulate	VERB
gs-3799	385	17	acute	acute	ADJ
gs-3799	385	18	intraoperative	intraoperative	ADJ
gs-3799	385	19	risks	risk	NOUN
gs-3799	385	20	(	(	PUNCT
gs-3799	385	21	e.g.	e.g.	ADV
gs-3799	385	22	,	,	PUNCT
gs-3799	385	23	hemodynamic	hemodynamic	ADJ
gs-3799	385	24	lability	lability	NOUN
gs-3799	385	25	,	,	PUNCT
gs-3799	385	26	coagulation	coagulation	NOUN
gs-3799	385	27	dysregulation	dysregulation	NOUN
gs-3799	385	28	)	)	PUNCT
gs-3799	385	29	rather	rather	ADV
gs-3799	385	30	than	than	ADP
gs-3799	385	31	overriding	override	VERB
gs-3799	385	32	preoperative	preoperative	ADJ
gs-3799	385	33	risk	risk	NOUN
gs-3799	385	34	factors	factor	NOUN
gs-3799	385	35	or	or	CCONJ
gs-3799	385	36	surgical	surgical	ADJ
gs-3799	385	37	technique	technique	NOUN
gs-3799	385	38	limitations	limitation	NOUN
gs-3799	385	39	.	.	PUNCT
gs-3799	386	1	furthermore	furthermore	ADV
gs-3799	386	2	,	,	PUNCT
gs-3799	386	3	the	the	DET
gs-3799	386	4	heterogeneity	heterogeneity	NOUN
gs-3799	386	5	in	in	ADP
gs-3799	386	6	system	system	NOUN
gs-3799	386	7	designs	design	NOUN
gs-3799	386	8	—	—	PUNCT
gs-3799	386	9	ranging	range	VERB
gs-3799	386	10	from	from	ADP
gs-3799	386	11	partial	partial	ADJ
gs-3799	386	12	automation	automation	NOUN
gs-3799	386	13	(	(	PUNCT
gs-3799	386	14	e.g.	e.g.	ADV
gs-3799	386	15	,	,	PUNCT
gs-3799	386	16	isolated	isolate	VERB
gs-3799	386	17	anticoagulation	anticoagulation	NOUN
gs-3799	386	18	control	control	NOUN
gs-3799	386	19	)	)	PUNCT
gs-3799	386	20	to	to	ADP
gs-3799	386	21	fully	fully	ADV
gs-3799	386	22	integrated	integrate	VERB
gs-3799	386	23	platforms	platform	NOUN
gs-3799	386	24	—	—	PUNCT
gs-3799	386	25	complicates	complicate	VERB
gs-3799	386	26	cross	cross	ADJ
gs-3799	386	27	-	-	ADJ
gs-3799	386	28	trial	trial	ADJ
gs-3799	386	29	comparisons	comparison	NOUN
gs-3799	386	30	.	.	PUNCT
gs-3799	387	1	systems	system	NOUN
gs-3799	387	2	employing	employ	VERB
gs-3799	387	3	artificial	artificial	ADJ
gs-3799	387	4	intelligence	intelligence	NOUN
gs-3799	387	5	for	for	ADP
gs-3799	387	6	predictive	predictive	ADJ
gs-3799	387	7	interventions	intervention	NOUN
gs-3799	387	8	,	,	PUNCT
gs-3799	387	9	though	though	SCONJ
gs-3799	387	10	promising	promise	VERB
gs-3799	387	11	,	,	PUNCT
gs-3799	387	12	face	face	VERB
gs-3799	387	13	validation	validation	NOUN
gs-3799	387	14	challenges	challenge	NOUN
gs-3799	387	15	due	due	ADP
gs-3799	387	16	to	to	ADP
gs-3799	387	17	algorithmic	algorithmic	ADJ
gs-3799	387	18	opacity	opacity	NOUN
gs-3799	387	19	and	and	CCONJ
gs-3799	387	20	limited	limited	ADJ
gs-3799	387	21	training	training	NOUN
gs-3799	387	22	datasets	dataset	NOUN
gs-3799	387	23	.	.	PUNCT
gs-3799	388	1	georgian	georgian	NOUN
gs-3799	388	2	scientists/	scientists/	NUM
gs-3799	388	3	.	.	PUNCT
gs-3799	389	1	7	7	NUM
gs-3799	389	2	n	n	DET
gs-3799	389	3	2	2	NUM
gs-3799	389	4	,	,	PUNCT
gs-3799	389	5	2025	2025	NUM
gs-3799	389	6	400	400	NUM
gs-3799	389	7	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	389	8	integration	integration	NOUN
gs-3799	389	9	emerges	emerge	VERB
gs-3799	389	10	as	as	ADP
gs-3799	389	11	both	both	CCONJ
gs-3799	389	12	a	a	DET
gs-3799	389	13	triumph	triumph	NOUN
gs-3799	389	14	and	and	CCONJ
gs-3799	389	15	a	a	DET
gs-3799	389	16	frontier	frontier	NOUN
gs-3799	389	17	.	.	PUNCT
gs-3799	390	1	automated	automate	VERB
gs-3799	390	2	heparin	heparin	ADJ
gs-3799	390	3	management	management	NOUN
gs-3799	390	4	,	,	PUNCT
gs-3799	390	5	validated	validate	VERB
gs-3799	390	6	across	across	ADP
gs-3799	390	7	multiple	multiple	ADJ
gs-3799	390	8	rcts	rct	NOUN
gs-3799	390	9	,	,	PUNCT
gs-3799	390	10	exemplifies	exemplify	VERB
gs-3799	390	11	closed	close	VERB
gs-3799	390	12	-	-	PUNCT
gs-3799	390	13	loop	loop	NOUN
gs-3799	390	14	success	success	NOUN
gs-3799	390	15	in	in	ADP
gs-3799	390	16	optimizing	optimize	VERB
gs-3799	390	17	therapeutic	therapeutic	ADJ
gs-3799	390	18	precision	precision	NOUN
gs-3799	390	19	.	.	PUNCT
gs-3799	391	1	yet	yet	ADV
gs-3799	391	2	,	,	PUNCT
gs-3799	391	3	opportunities	opportunity	NOUN
gs-3799	391	4	abound	abound	VERB
gs-3799	391	5	for	for	ADP
gs-3799	391	6	extending	extend	VERB
gs-3799	391	7	automation	automation	NOUN
gs-3799	391	8	to	to	ADP
gs-3799	391	9	vasoactive	vasoactive	ADJ
gs-3799	391	10	agents	agent	NOUN
gs-3799	391	11	,	,	PUNCT
gs-3799	391	12	anti	anti	ADJ
gs-3799	391	13	-	-	ADJ
gs-3799	391	14	inflammatory	inflammatory	ADJ
gs-3799	391	15	therapies	therapy	NOUN
gs-3799	391	16	,	,	PUNCT
gs-3799	391	17	and	and	CCONJ
gs-3799	391	18	volume	volume	NOUN
gs-3799	391	19	management	management	NOUN
gs-3799	391	20	,	,	PUNCT
gs-3799	391	21	where	where	SCONJ
gs-3799	391	22	physiological	physiological	ADJ
gs-3799	391	23	feedback	feedback	NOUN
gs-3799	391	24	loops	loop	NOUN
gs-3799	391	25	are	be	AUX
gs-3799	391	26	equally	equally	ADV
gs-3799	391	27	critical	critical	ADJ
gs-3799	391	28	but	but	CCONJ
gs-3799	391	29	algorithmically	algorithmically	ADV
gs-3799	391	30	complex	complex	ADJ
gs-3799	391	31	.	.	PUNCT
gs-3799	392	1	the	the	DET
gs-3799	392	2	absence	absence	NOUN
gs-3799	392	3	of	of	ADP
gs-3799	392	4	standardized	standardized	ADJ
gs-3799	392	5	pharmacogenomic	pharmacogenomic	ADJ
gs-3799	392	6	integration	integration	NOUN
gs-3799	392	7	—	—	PUNCT
gs-3799	392	8	where	where	SCONJ
gs-3799	392	9	real	real	ADJ
gs-3799	392	10	-	-	PUNCT
gs-3799	392	11	time	time	NOUN
gs-3799	392	12	genetic	genetic	ADJ
gs-3799	392	13	data	datum	NOUN
gs-3799	392	14	could	could	AUX
gs-3799	392	15	refine	refine	VERB
gs-3799	392	16	drug	drug	NOUN
gs-3799	392	17	dosing	dosing	NOUN
gs-3799	392	18	—	—	PUNCT
gs-3799	392	19	represents	represent	VERB
gs-3799	392	20	a	a	DET
gs-3799	392	21	significant	significant	ADJ
gs-3799	392	22	untapped	untapped	ADJ
gs-3799	392	23	potential	potential	NOUN
gs-3799	392	24	for	for	ADP
gs-3799	392	25	personalized	personalized	ADJ
gs-3799	392	26	perfusion	perfusion	NOUN
gs-3799	392	27	.	.	PUNCT
gs-3799	393	1	equally	equally	ADV
gs-3799	393	2	critical	critical	ADJ
gs-3799	393	3	are	be	AUX
gs-3799	393	4	human	human	ADJ
gs-3799	393	5	-	-	PUNCT
gs-3799	393	6	factors	factor	NOUN
gs-3799	393	7	considerations	consideration	NOUN
gs-3799	393	8	;	;	PUNCT
gs-3799	393	9	perfusionists	perfusionist	NOUN
gs-3799	393	10	transitioning	transition	VERB
gs-3799	393	11	from	from	ADP
gs-3799	393	12	manual	manual	ADJ
gs-3799	393	13	operators	operator	NOUN
gs-3799	393	14	to	to	PART
gs-3799	393	15	system	system	NOUN
gs-3799	393	16	supervisors	supervisor	NOUN
gs-3799	393	17	require	require	VERB
gs-3799	393	18	redesigned	redesign	VERB
gs-3799	393	19	training	training	NOUN
gs-3799	393	20	paradigms	paradigm	NOUN
gs-3799	393	21	emphasizing	emphasize	VERB
gs-3799	393	22	algorithm	algorithm	NOUN
gs-3799	393	23	oversight	oversight	NOUN
gs-3799	393	24	,	,	PUNCT
gs-3799	393	25	failure	failure	NOUN
gs-3799	393	26	-	-	PUNCT
gs-3799	393	27	mode	mode	NOUN
gs-3799	393	28	management	management	NOUN
gs-3799	393	29	,	,	PUNCT
gs-3799	393	30	and	and	CCONJ
gs-3799	393	31	data	datum	NOUN
gs-3799	393	32	interpretation	interpretation	NOUN
gs-3799	393	33	.	.	PUNCT
gs-3799	394	1	the	the	DET
gs-3799	394	2	translational	translational	ADJ
gs-3799	394	3	barriers	barrier	NOUN
gs-3799	394	4	identified	identify	VERB
gs-3799	394	5	extend	extend	NOUN
gs-3799	394	6	beyond	beyond	ADP
gs-3799	394	7	technology	technology	NOUN
gs-3799	394	8	.	.	PUNCT
gs-3799	395	1	regulatory	regulatory	ADJ
gs-3799	395	2	frameworks	framework	NOUN
gs-3799	395	3	lag	lag	VERB
gs-3799	395	4	in	in	ADP
gs-3799	395	5	addressing	address	VERB
gs-3799	395	6	adaptive	adaptive	ADJ
gs-3799	395	7	closed	closed	ADJ
gs-3799	395	8	-	-	PUNCT
gs-3799	395	9	loop	loop	NOUN
gs-3799	395	10	devices	device	NOUN
gs-3799	395	11	,	,	PUNCT
gs-3799	395	12	lacking	lack	VERB
gs-3799	395	13	clear	clear	ADJ
gs-3799	395	14	pathways	pathway	NOUN
gs-3799	395	15	for	for	ADP
gs-3799	395	16	validating	validate	VERB
gs-3799	395	17	evolving	evolve	VERB
gs-3799	395	18	ai	ai	ADJ
gs-3799	395	19	-	-	PUNCT
gs-3799	395	20	driven	drive	VERB
gs-3799	395	21	systems	system	NOUN
gs-3799	395	22	.	.	PUNCT
gs-3799	396	1	cost	cost	NOUN
gs-3799	396	2	-	-	PUNCT
gs-3799	396	3	benefit	benefit	NOUN
gs-3799	396	4	analyses	analysis	NOUN
gs-3799	396	5	,	,	PUNCT
gs-3799	396	6	though	though	SCONJ
gs-3799	396	7	indicating	indicate	VERB
gs-3799	396	8	long	long	ADJ
gs-3799	396	9	-	-	PUNCT
gs-3799	396	10	term	term	NOUN
gs-3799	396	11	savings	saving	NOUN
gs-3799	396	12	from	from	ADP
gs-3799	396	13	reduced	reduced	ADJ
gs-3799	396	14	complications	complication	NOUN
gs-3799	396	15	,	,	PUNCT
gs-3799	396	16	struggle	struggle	VERB
gs-3799	396	17	to	to	PART
gs-3799	396	18	justify	justify	VERB
gs-3799	396	19	upfront	upfront	ADJ
gs-3799	396	20	investments	investment	NOUN
gs-3799	396	21	in	in	ADP
gs-3799	396	22	resource	resource	NOUN
gs-3799	396	23	-	-	PUNCT
gs-3799	396	24	constrained	constrain	VERB
gs-3799	396	25	settings	setting	NOUN
gs-3799	396	26	.	.	PUNCT
gs-3799	397	1	moreover	moreover	ADV
gs-3799	397	2	,	,	PUNCT
gs-3799	397	3	persistent	persistent	ADJ
gs-3799	397	4	fragmentation	fragmentation	NOUN
gs-3799	397	5	in	in	ADP
gs-3799	397	6	proprietary	proprietary	ADJ
gs-3799	397	7	system	system	NOUN
gs-3799	397	8	architectures	architecture	NOUN
gs-3799	397	9	impedes	impede	VERB
gs-3799	397	10	interoperability	interoperability	NOUN
gs-3799	397	11	,	,	PUNCT
gs-3799	397	12	data	datum	NOUN
gs-3799	397	13	sharing	sharing	NOUN
gs-3799	397	14	,	,	PUNCT
gs-3799	397	15	and	and	CCONJ
gs-3799	397	16	largescale	largescale	NOUN
gs-3799	397	17	evidence	evidence	NOUN
gs-3799	397	18	generation	generation	NOUN
gs-3799	397	19	.	.	PUNCT
gs-3799	398	1	these	these	DET
gs-3799	398	2	challenges	challenge	NOUN
gs-3799	398	3	collectively	collectively	ADV
gs-3799	398	4	underscore	underscore	VERB
gs-3799	398	5	that	that	DET
gs-3799	398	6	technological	technological	ADJ
gs-3799	398	7	maturity	maturity	NOUN
gs-3799	398	8	alone	alone	ADV
gs-3799	398	9	is	be	AUX
gs-3799	398	10	insufficient	insufficient	ADJ
gs-3799	398	11	;	;	PUNCT
gs-3799	398	12	widespread	widespread	ADJ
gs-3799	398	13	adoption	adoption	NOUN
gs-3799	398	14	necessitates	necessitate	VERB
gs-3799	398	15	parallel	parallel	ADJ
gs-3799	398	16	advances	advance	NOUN
gs-3799	398	17	in	in	ADP
gs-3799	398	18	reimbursement	reimbursement	NOUN
gs-3799	398	19	models	model	NOUN
gs-3799	398	20	,	,	PUNCT
gs-3799	398	21	regulatory	regulatory	ADJ
gs-3799	398	22	science	science	NOUN
gs-3799	398	23	,	,	PUNCT
gs-3799	398	24	and	and	CCONJ
gs-3799	398	25	global	global	ADJ
gs-3799	398	26	access	access	NOUN
gs-3799	398	27	strategies	strategy	NOUN
gs-3799	398	28	.	.	PUNCT
gs-3799	399	1	in	in	ADP
gs-3799	399	2	synthesizing	synthesize	VERB
gs-3799	399	3	these	these	DET
gs-3799	399	4	dimensions	dimension	NOUN
gs-3799	399	5	,	,	PUNCT
gs-3799	399	6	this	this	DET
gs-3799	399	7	research	research	NOUN
gs-3799	399	8	affirms	affirm	VERB
gs-3799	399	9	that	that	SCONJ
gs-3799	399	10	closed	close	VERB
gs-3799	399	11	-	-	PUNCT
gs-3799	399	12	loop	loop	NOUN
gs-3799	399	13	cpb	cpb	NOUN
gs-3799	399	14	systems	system	NOUN
gs-3799	399	15	are	be	AUX
gs-3799	399	16	not	not	PART
gs-3799	399	17	merely	merely	ADV
gs-3799	399	18	incremental	incremental	ADJ
gs-3799	399	19	improvements	improvement	NOUN
gs-3799	399	20	but	but	CCONJ
gs-3799	399	21	foundational	foundational	ADJ
gs-3799	399	22	shifts	shift	NOUN
gs-3799	399	23	toward	toward	ADP
gs-3799	399	24	intelligent	intelligent	ADJ
gs-3799	399	25	,	,	PUNCT
gs-3799	399	26	patient	patient	NOUN
gs-3799	399	27	-	-	PUNCT
gs-3799	399	28	centered	center	VERB
gs-3799	399	29	perfusion	perfusion	NOUN
gs-3799	399	30	.	.	PUNCT
gs-3799	400	1	their	their	PRON
gs-3799	400	2	ultimate	ultimate	ADJ
gs-3799	400	3	clinical	clinical	ADJ
gs-3799	400	4	value	value	NOUN
gs-3799	400	5	will	will	AUX
gs-3799	400	6	depend	depend	VERB
gs-3799	400	7	on	on	ADP
gs-3799	400	8	resolving	resolve	VERB
gs-3799	400	9	key	key	ADJ
gs-3799	400	10	tensions	tension	NOUN
gs-3799	400	11	:	:	PUNCT
gs-3799	400	12	between	between	ADP
gs-3799	400	13	algorithmic	algorithmic	ADJ
gs-3799	400	14	sophistication	sophistication	NOUN
gs-3799	400	15	and	and	CCONJ
gs-3799	400	16	interpretability	interpretability	NOUN
gs-3799	400	17	,	,	PUNCT
gs-3799	400	18	between	between	ADP
gs-3799	400	19	automation	automation	NOUN
gs-3799	400	20	and	and	CCONJ
gs-3799	400	21	human	human	ADJ
gs-3799	400	22	agency	agency	NOUN
gs-3799	400	23	,	,	PUNCT
gs-3799	400	24	and	and	CCONJ
gs-3799	400	25	between	between	ADP
gs-3799	400	26	technological	technological	ADJ
gs-3799	400	27	ambition	ambition	NOUN
gs-3799	400	28	and	and	CCONJ
gs-3799	400	29	pragmatic	pragmatic	ADJ
gs-3799	400	30	implementation	implementation	NOUN
gs-3799	400	31	.	.	PUNCT
gs-3799	401	1	future	future	ADJ
gs-3799	401	2	progress	progress	NOUN
gs-3799	401	3	demands	demand	VERB
gs-3799	401	4	co	co	NOUN
gs-3799	401	5	-	-	NOUN
gs-3799	401	6	development	development	NOUN
gs-3799	401	7	—	—	PUNCT
gs-3799	401	8	clinicians	clinician	NOUN
gs-3799	401	9	,	,	PUNCT
gs-3799	401	10	engineers	engineer	NOUN
gs-3799	401	11	,	,	PUNCT
gs-3799	401	12	and	and	CCONJ
gs-3799	401	13	policymakers	policymaker	NOUN
gs-3799	401	14	collaboratively	collaboratively	ADV
gs-3799	401	15	refining	refine	VERB
gs-3799	401	16	architectures	architecture	NOUN
gs-3799	401	17	,	,	PUNCT
gs-3799	401	18	validating	validate	VERB
gs-3799	401	19	real	real	ADJ
gs-3799	401	20	-	-	PUNCT
gs-3799	401	21	world	world	NOUN
gs-3799	401	22	efficacy	efficacy	NOUN
gs-3799	401	23	,	,	PUNCT
gs-3799	401	24	and	and	CCONJ
gs-3799	401	25	ensuring	ensure	VERB
gs-3799	401	26	equitable	equitable	ADJ
gs-3799	401	27	deployment	deployment	NOUN
gs-3799	401	28	—	—	PUNCT
gs-3799	401	29	to	to	PART
gs-3799	401	30	translate	translate	VERB
gs-3799	401	31	engineering	engineering	NOUN
gs-3799	401	32	innovation	innovation	NOUN
gs-3799	401	33	into	into	ADP
gs-3799	401	34	tangible	tangible	ADJ
gs-3799	401	35	patient	patient	NOUN
gs-3799	401	36	benefit	benefit	NOUN
gs-3799	401	37	across	across	ADP
gs-3799	401	38	the	the	DET
gs-3799	401	39	cardiac	cardiac	ADJ
gs-3799	401	40	surgical	surgical	ADJ
gs-3799	401	41	landscape	landscape	NOUN
gs-3799	401	42	.	.	PUNCT
gs-3799	402	1	additionally	additionally	ADV
gs-3799	402	2	,	,	PUNCT
gs-3799	402	3	the	the	DET
gs-3799	402	4	field	field	NOUN
gs-3799	402	5	is	be	AUX
gs-3799	402	6	now	now	ADV
gs-3799	402	7	beginning	begin	VERB
gs-3799	402	8	to	to	PART
gs-3799	402	9	appreciate	appreciate	VERB
gs-3799	402	10	the	the	DET
gs-3799	402	11	role	role	NOUN
gs-3799	402	12	of	of	ADP
gs-3799	402	13	circadian	circadian	ADJ
gs-3799	402	14	biology	biology	NOUN
gs-3799	402	15	and	and	CCONJ
gs-3799	402	16	metabolic	metabolic	NOUN
gs-3799	402	17	variance	variance	NOUN
gs-3799	402	18	during	during	ADP
gs-3799	402	19	surgery	surgery	NOUN
gs-3799	402	20	.	.	PUNCT
gs-3799	403	1	diurnal	diurnal	ADJ
gs-3799	403	2	variations	variation	NOUN
gs-3799	403	3	in	in	ADP
gs-3799	403	4	systemic	systemic	ADJ
gs-3799	403	5	inflammation	inflammation	NOUN
gs-3799	403	6	,	,	PUNCT
gs-3799	403	7	hormonal	hormonal	ADJ
gs-3799	403	8	secretion	secretion	NOUN
gs-3799	403	9	,	,	PUNCT
gs-3799	403	10	and	and	CCONJ
gs-3799	403	11	endothelial	endothelial	ADJ
gs-3799	403	12	responsiveness	responsiveness	NOUN
gs-3799	403	13	can	can	AUX
gs-3799	403	14	alter	alter	VERB
gs-3799	403	15	patient	patient	ADJ
gs-3799	403	16	trajectories	trajectory	NOUN
gs-3799	403	17	on	on	ADP
gs-3799	403	18	bypass	bypass	NOUN
gs-3799	403	19	.	.	PUNCT
gs-3799	404	1	advanced	advanced	ADJ
gs-3799	404	2	closed	close	VERB
gs-3799	404	3	-	-	PUNCT
gs-3799	404	4	loop	loop	NOUN
gs-3799	404	5	systems	system	NOUN
gs-3799	404	6	that	that	PRON
gs-3799	404	7	integrate	integrate	VERB
gs-3799	404	8	chronobiologic	chronobiologic	ADJ
gs-3799	404	9	inputs	input	NOUN
gs-3799	404	10	into	into	ADP
gs-3799	404	11	control	control	NOUN
gs-3799	404	12	logic	logic	NOUN
gs-3799	404	13	represent	represent	VERB
gs-3799	404	14	a	a	DET
gs-3799	404	15	novel	novel	ADJ
gs-3799	404	16	concept	concept	NOUN
gs-3799	404	17	that	that	PRON
gs-3799	404	18	could	could	AUX
gs-3799	404	19	align	align	VERB
gs-3799	404	20	perfusion	perfusion	NOUN
gs-3799	404	21	and	and	CCONJ
gs-3799	404	22	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	404	23	with	with	ADP
gs-3799	404	24	the	the	DET
gs-3799	404	25	body	body	NOUN
gs-3799	404	26	's	's	PART
gs-3799	404	27	innate	innate	ADJ
gs-3799	404	28	temporal	temporal	ADJ
gs-3799	404	29	physiology	physiology	NOUN
gs-3799	404	30	.	.	PUNCT
gs-3799	405	1	preliminary	preliminary	ADJ
gs-3799	405	2	investigations	investigation	NOUN
gs-3799	405	3	show	show	VERB
gs-3799	405	4	that	that	SCONJ
gs-3799	405	5	patients	patient	NOUN
gs-3799	405	6	undergoing	undergo	VERB
gs-3799	405	7	surgery	surgery	NOUN
gs-3799	405	8	in	in	ADP
gs-3799	405	9	the	the	DET
gs-3799	405	10	morning	morning	NOUN
gs-3799	405	11	versus	versus	ADP
gs-3799	405	12	afternoon	afternoon	NOUN
gs-3799	405	13	may	may	AUX
gs-3799	405	14	exhibit	exhibit	VERB
gs-3799	405	15	different	different	ADJ
gs-3799	405	16	inflammatory	inflammatory	ADJ
gs-3799	405	17	and	and	CCONJ
gs-3799	405	18	hemodynamic	hemodynamic	ADJ
gs-3799	405	19	responses	response	NOUN
gs-3799	405	20	,	,	PUNCT
gs-3799	405	21	with	with	ADP
gs-3799	405	22	closed	closed	ADJ
gs-3799	405	23	-	-	PUNCT
gs-3799	405	24	loop	loop	NOUN
gs-3799	405	25	algorithms	algorithm	NOUN
gs-3799	405	26	capable	capable	ADJ
gs-3799	405	27	of	of	ADP
gs-3799	405	28	modulating	modulate	VERB
gs-3799	405	29	these	these	DET
gs-3799	405	30	rhythms	rhythm	NOUN
gs-3799	405	31	more	more	ADV
gs-3799	405	32	effectively	effectively	ADV
gs-3799	405	33	than	than	ADP
gs-3799	405	34	static	static	ADJ
gs-3799	405	35	protocols	protocol	NOUN
gs-3799	405	36	.	.	PUNCT
gs-3799	406	1	machine	machine	NOUN
gs-3799	406	2	learning	learning	NOUN
gs-3799	406	3	,	,	PUNCT
gs-3799	406	4	beyond	beyond	ADP
gs-3799	406	5	its	its	PRON
gs-3799	406	6	role	role	NOUN
gs-3799	406	7	in	in	ADP
gs-3799	406	8	pattern	pattern	NOUN
gs-3799	406	9	recognition	recognition	NOUN
gs-3799	406	10	and	and	CCONJ
gs-3799	406	11	predictive	predictive	ADJ
gs-3799	406	12	analytics	analytic	NOUN
gs-3799	406	13	,	,	PUNCT
gs-3799	406	14	is	be	AUX
gs-3799	406	15	beginning	begin	VERB
gs-3799	406	16	to	to	PART
gs-3799	406	17	enter	enter	VERB
gs-3799	406	18	the	the	DET
gs-3799	406	19	realm	realm	NOUN
gs-3799	406	20	of	of	ADP
gs-3799	406	21	self	self	NOUN
gs-3799	406	22	-	-	PUNCT
gs-3799	406	23	optimizing	optimize	VERB
gs-3799	406	24	control	control	NOUN
gs-3799	406	25	in	in	ADP
gs-3799	406	26	cpb	cpb	PROPN
gs-3799	406	27	.	.	PUNCT
gs-3799	407	1	unlike	unlike	ADP
gs-3799	407	2	rule	rule	NOUN
gs-3799	407	3	-	-	PUNCT
gs-3799	407	4	based	base	VERB
gs-3799	407	5	systems	system	NOUN
gs-3799	407	6	,	,	PUNCT
gs-3799	407	7	which	which	PRON
gs-3799	407	8	require	require	VERB
gs-3799	407	9	predefined	predefine	VERB
gs-3799	407	10	thresholds	threshold	NOUN
gs-3799	407	11	and	and	CCONJ
gs-3799	407	12	response	response	NOUN
gs-3799	407	13	pathways	pathway	NOUN
gs-3799	407	14	,	,	PUNCT
gs-3799	407	15	learning	learn	VERB
gs-3799	407	16	algorithms	algorithm	NOUN
gs-3799	407	17	can	can	AUX
gs-3799	407	18	adjust	adjust	VERB
gs-3799	407	19	control	control	NOUN
gs-3799	407	20	behavior	behavior	NOUN
gs-3799	407	21	over	over	ADP
gs-3799	407	22	time	time	NOUN
gs-3799	407	23	based	base	VERB
gs-3799	407	24	on	on	ADP
gs-3799	407	25	observed	observed	ADJ
gs-3799	407	26	outcomes	outcome	NOUN
gs-3799	407	27	and	and	CCONJ
gs-3799	407	28	intraoperative	intraoperative	ADJ
gs-3799	407	29	variables	variable	NOUN
gs-3799	407	30	.	.	PUNCT
gs-3799	408	1	this	this	PRON
gs-3799	408	2	enables	enable	VERB
gs-3799	408	3	the	the	DET
gs-3799	408	4	system	system	NOUN
gs-3799	408	5	to	to	PART
gs-3799	408	6	‘	'	PUNCT
gs-3799	408	7	learn	learn	VERB
gs-3799	408	8	’	'	PUNCT
gs-3799	408	9	from	from	ADP
gs-3799	408	10	previous	previous	ADJ
gs-3799	408	11	bypasses	bypass	NOUN
gs-3799	408	12	,	,	PUNCT
gs-3799	408	13	adapting	adapt	VERB
gs-3799	408	14	to	to	ADP
gs-3799	408	15	surgical	surgical	ADJ
gs-3799	408	16	team	team	NOUN
gs-3799	408	17	patterns	pattern	NOUN
gs-3799	408	18	,	,	PUNCT
gs-3799	408	19	patient	patient	ADJ
gs-3799	408	20	demographics	demographic	NOUN
gs-3799	408	21	,	,	PUNCT
gs-3799	408	22	and	and	CCONJ
gs-3799	408	23	institutional	institutional	ADJ
gs-3799	408	24	norms	norm	NOUN
gs-3799	408	25	.	.	PUNCT
gs-3799	409	1	the	the	DET
gs-3799	409	2	concept	concept	NOUN
gs-3799	409	3	of	of	ADP
gs-3799	409	4	intraoperative	intraoperative	ADJ
gs-3799	409	5	learning	learning	NOUN
gs-3799	409	6	,	,	PUNCT
gs-3799	409	7	wherein	wherein	SCONJ
gs-3799	409	8	the	the	DET
gs-3799	409	9	system	system	NOUN
gs-3799	409	10	improves	improve	VERB
gs-3799	409	11	its	its	PRON
gs-3799	409	12	accuracy	accuracy	NOUN
gs-3799	409	13	and	and	CCONJ
gs-3799	409	14	responsiveness	responsiveness	NOUN
gs-3799	409	15	with	with	ADP
gs-3799	409	16	each	each	DET
gs-3799	409	17	procedure	procedure	NOUN
gs-3799	409	18	,	,	PUNCT
gs-3799	409	19	is	be	AUX
gs-3799	409	20	now	now	ADV
gs-3799	409	21	a	a	DET
gs-3799	409	22	focal	focal	ADJ
gs-3799	409	23	point	point	NOUN
gs-3799	409	24	in	in	ADP
gs-3799	409	25	next	next	ADJ
gs-3799	409	26	-	-	PUNCT
gs-3799	409	27	generation	generation	NOUN
gs-3799	409	28	system	system	NOUN
gs-3799	409	29	design	design	NOUN
gs-3799	409	30	.	.	PUNCT
gs-3799	410	1	early	early	ADJ
gs-3799	410	2	implementations	implementation	NOUN
gs-3799	410	3	georgian	georgian	NOUN
gs-3799	410	4	scientists/	scientists/	NUM
gs-3799	410	5	.	.	PUNCT
gs-3799	411	1	7	7	NUM
gs-3799	411	2	n	n	DET
gs-3799	411	3	2	2	NUM
gs-3799	411	4	,	,	PUNCT
gs-3799	411	5	2025	2025	NUM
gs-3799	411	6	401	401	NUM
gs-3799	411	7	demonstrate	demonstrate	VERB
gs-3799	411	8	that	that	SCONJ
gs-3799	411	9	adaptive	adaptive	ADJ
gs-3799	411	10	control	control	NOUN
gs-3799	411	11	algorithms	algorithm	NOUN
gs-3799	411	12	can	can	AUX
gs-3799	411	13	reduce	reduce	VERB
gs-3799	411	14	time	time	NOUN
gs-3799	411	15	-	-	PUNCT
gs-3799	411	16	to	to	ADP
gs-3799	411	17	-	-	PUNCT
gs-3799	411	18	stability	stability	NOUN
gs-3799	411	19	and	and	CCONJ
gs-3799	411	20	decrease	decrease	VERB
gs-3799	411	21	the	the	DET
gs-3799	411	22	need	need	NOUN
gs-3799	411	23	for	for	ADP
gs-3799	411	24	manual	manual	ADJ
gs-3799	411	25	overrides	override	VERB
gs-3799	411	26	,	,	PUNCT
gs-3799	411	27	although	although	SCONJ
gs-3799	411	28	they	they	PRON
gs-3799	411	29	remain	remain	VERB
gs-3799	411	30	heavily	heavily	ADV
gs-3799	411	31	reliant	reliant	ADJ
gs-3799	411	32	on	on	ADP
gs-3799	411	33	comprehensive	comprehensive	ADJ
gs-3799	411	34	training	training	NOUN
gs-3799	411	35	datasets	dataset	NOUN
gs-3799	411	36	.	.	PUNCT
gs-3799	412	1	a	a	DET
gs-3799	412	2	particularly	particularly	ADV
gs-3799	412	3	sensitive	sensitive	ADJ
gs-3799	412	4	yet	yet	CCONJ
gs-3799	412	5	underrepresented	underrepresented	ADJ
gs-3799	412	6	domain	domain	NOUN
gs-3799	412	7	is	be	AUX
gs-3799	412	8	the	the	DET
gs-3799	412	9	application	application	NOUN
gs-3799	412	10	of	of	ADP
gs-3799	412	11	closed	closed	ADJ
gs-3799	412	12	-	-	PUNCT
gs-3799	412	13	loop	loop	NOUN
gs-3799	412	14	systems	system	NOUN
gs-3799	412	15	in	in	ADP
gs-3799	412	16	pediatric	pediatric	ADJ
gs-3799	412	17	cardiac	cardiac	ADJ
gs-3799	412	18	surgery	surgery	NOUN
gs-3799	412	19	.	.	PUNCT
gs-3799	413	1	the	the	DET
gs-3799	413	2	unique	unique	ADJ
gs-3799	413	3	physiologic	physiologic	ADJ
gs-3799	413	4	characteristics	characteristic	NOUN
gs-3799	413	5	of	of	ADP
gs-3799	413	6	neonates	neonate	NOUN
gs-3799	413	7	and	and	CCONJ
gs-3799	413	8	infants	infant	NOUN
gs-3799	413	9	—	—	PUNCT
gs-3799	413	10	including	include	VERB
gs-3799	413	11	immature	immature	ADJ
gs-3799	413	12	organ	organ	NOUN
gs-3799	413	13	systems	system	NOUN
gs-3799	413	14	,	,	PUNCT
gs-3799	413	15	smaller	small	ADJ
gs-3799	413	16	circulating	circulating	ADJ
gs-3799	413	17	volumes	volume	NOUN
gs-3799	413	18	,	,	PUNCT
gs-3799	413	19	higher	high	ADJ
gs-3799	413	20	surface	surface	NOUN
gs-3799	413	21	-	-	PUNCT
gs-3799	413	22	area	area	NOUN
gs-3799	413	23	-	-	PUNCT
gs-3799	413	24	to	to	ADP
gs-3799	413	25	-	-	PUNCT
gs-3799	413	26	volume	volume	NOUN
gs-3799	413	27	ratios	ratio	NOUN
gs-3799	413	28	,	,	PUNCT
gs-3799	413	29	and	and	CCONJ
gs-3799	413	30	more	more	ADJ
gs-3799	413	31	labile	labile	ADJ
gs-3799	413	32	metabolic	metabolic	NOUN
gs-3799	413	33	parameters	parameter	NOUN
gs-3799	413	34	—	—	PUNCT
gs-3799	413	35	pose	pose	VERB
gs-3799	413	36	significant	significant	ADJ
gs-3799	413	37	challenges	challenge	NOUN
gs-3799	413	38	for	for	ADP
gs-3799	413	39	traditional	traditional	ADJ
gs-3799	413	40	cpb	cpb	NOUN
gs-3799	413	41	management	management	NOUN
gs-3799	413	42	.	.	PUNCT
gs-3799	414	1	in	in	ADP
gs-3799	414	2	this	this	DET
gs-3799	414	3	context	context	NOUN
gs-3799	414	4	,	,	PUNCT
gs-3799	414	5	the	the	DET
gs-3799	414	6	granularity	granularity	NOUN
gs-3799	414	7	of	of	ADP
gs-3799	414	8	data	datum	NOUN
gs-3799	414	9	and	and	CCONJ
gs-3799	414	10	responsiveness	responsiveness	NOUN
gs-3799	414	11	of	of	ADP
gs-3799	414	12	control	control	NOUN
gs-3799	414	13	systems	system	NOUN
gs-3799	414	14	become	become	VERB
gs-3799	414	15	critically	critically	ADV
gs-3799	414	16	important	important	ADJ
gs-3799	414	17	.	.	PUNCT
gs-3799	415	1	closed	close	VERB
gs-3799	415	2	-	-	PUNCT
gs-3799	415	3	loop	loop	NOUN
gs-3799	415	4	systems	system	NOUN
gs-3799	415	5	developed	develop	VERB
gs-3799	415	6	for	for	ADP
gs-3799	415	7	pediatric	pediatric	ADJ
gs-3799	415	8	use	use	NOUN
gs-3799	415	9	require	require	VERB
gs-3799	415	10	enhanced	enhance	VERB
gs-3799	415	11	precision	precision	NOUN
gs-3799	415	12	in	in	ADP
gs-3799	415	13	flow	flow	NOUN
gs-3799	415	14	regulation	regulation	NOUN
gs-3799	415	15	,	,	PUNCT
gs-3799	415	16	thermal	thermal	ADJ
gs-3799	415	17	control	control	NOUN
gs-3799	415	18	,	,	PUNCT
gs-3799	415	19	and	and	CCONJ
gs-3799	415	20	drug	drug	NOUN
gs-3799	415	21	dosing	dosing	NOUN
gs-3799	415	22	.	.	PUNCT
gs-3799	416	1	simulated	simulate	VERB
gs-3799	416	2	pediatric	pediatric	ADJ
gs-3799	416	3	trials	trial	NOUN
gs-3799	416	4	reveal	reveal	VERB
gs-3799	416	5	that	that	SCONJ
gs-3799	416	6	micro	micro	NOUN
gs-3799	416	7	-	-	NOUN
gs-3799	416	8	adjustments	adjustment	NOUN
gs-3799	416	9	in	in	ADP
gs-3799	416	10	temperature	temperature	NOUN
gs-3799	416	11	and	and	CCONJ
gs-3799	416	12	hematocrit	hematocrit	NOUN
gs-3799	416	13	,	,	PUNCT
gs-3799	416	14	guided	guide	VERB
gs-3799	416	15	by	by	ADP
gs-3799	416	16	rapid	rapid	ADJ
gs-3799	416	17	feedback	feedback	NOUN
gs-3799	416	18	,	,	PUNCT
gs-3799	416	19	can	can	AUX
gs-3799	416	20	reduce	reduce	VERB
gs-3799	416	21	neurologic	neurologic	ADJ
gs-3799	416	22	sequelae	sequelae	NOUN
gs-3799	416	23	and	and	CCONJ
gs-3799	416	24	support	support	VERB
gs-3799	416	25	better	well	ADJ
gs-3799	416	26	organ	organ	NOUN
gs-3799	416	27	maturation	maturation	NOUN
gs-3799	416	28	postoperatively	postoperatively	ADV
gs-3799	416	29	.	.	PUNCT
gs-3799	417	1	the	the	DET
gs-3799	417	2	ethical	ethical	ADJ
gs-3799	417	3	imperative	imperative	NOUN
gs-3799	417	4	to	to	PART
gs-3799	417	5	protect	protect	VERB
gs-3799	417	6	the	the	DET
gs-3799	417	7	most	most	ADV
gs-3799	417	8	vulnerable	vulnerable	ADJ
gs-3799	417	9	patients	patient	NOUN
gs-3799	417	10	provides	provide	VERB
gs-3799	417	11	strong	strong	ADJ
gs-3799	417	12	motivation	motivation	NOUN
gs-3799	417	13	for	for	ADP
gs-3799	417	14	accelerated	accelerated	ADJ
gs-3799	417	15	innovation	innovation	NOUN
gs-3799	417	16	in	in	ADP
gs-3799	417	17	this	this	DET
gs-3799	417	18	subfield	subfield	NOUN
gs-3799	417	19	,	,	PUNCT
gs-3799	417	20	albeit	albeit	SCONJ
gs-3799	417	21	with	with	ADP
gs-3799	417	22	rigorous	rigorous	ADJ
gs-3799	417	23	safety	safety	NOUN
gs-3799	417	24	and	and	CCONJ
gs-3799	417	25	testing	testing	NOUN
gs-3799	417	26	protocols	protocol	NOUN
gs-3799	417	27	.	.	PUNCT
gs-3799	418	1	the	the	DET
gs-3799	418	2	incorporation	incorporation	NOUN
gs-3799	418	3	of	of	ADP
gs-3799	418	4	real	real	ADJ
gs-3799	418	5	-	-	PUNCT
gs-3799	418	6	time	time	NOUN
gs-3799	418	7	biomarker	biomarker	NOUN
gs-3799	418	8	analysis	analysis	NOUN
gs-3799	418	9	into	into	ADP
gs-3799	418	10	feedback	feedback	NOUN
gs-3799	418	11	loops	loop	NOUN
gs-3799	418	12	marks	mark	VERB
gs-3799	418	13	a	a	DET
gs-3799	418	14	pivotal	pivotal	ADJ
gs-3799	418	15	enhancement	enhancement	NOUN
gs-3799	418	16	to	to	ADP
gs-3799	418	17	closed	close	VERB
gs-3799	418	18	-	-	PUNCT
gs-3799	418	19	loop	loop	NOUN
gs-3799	418	20	cpb	cpb	PROPN
gs-3799	418	21	.	.	PUNCT
gs-3799	419	1	devices	device	NOUN
gs-3799	419	2	capable	capable	ADJ
gs-3799	419	3	of	of	ADP
gs-3799	419	4	continuously	continuously	ADV
gs-3799	419	5	measuring	measure	VERB
gs-3799	419	6	lactate	lactate	NOUN
gs-3799	419	7	,	,	PUNCT
gs-3799	419	8	procalcitonin	procalcitonin	ADJ
gs-3799	419	9	,	,	PUNCT
gs-3799	419	10	troponin	troponin	ADJ
gs-3799	419	11	,	,	PUNCT
gs-3799	419	12	and	and	CCONJ
gs-3799	419	13	inflammatory	inflammatory	ADJ
gs-3799	419	14	cytokines	cytokine	NOUN
gs-3799	419	15	are	be	AUX
gs-3799	419	16	being	be	AUX
gs-3799	419	17	developed	develop	VERB
gs-3799	419	18	for	for	ADP
gs-3799	419	19	integration	integration	NOUN
gs-3799	419	20	into	into	ADP
gs-3799	419	21	perfusion	perfusion	NOUN
gs-3799	419	22	circuits	circuit	NOUN
gs-3799	419	23	.	.	PUNCT
gs-3799	420	1	the	the	DET
gs-3799	420	2	ability	ability	NOUN
gs-3799	420	3	to	to	PART
gs-3799	420	4	adjust	adjust	VERB
gs-3799	420	5	oxygen	oxygen	NOUN
gs-3799	420	6	delivery	delivery	NOUN
gs-3799	420	7	,	,	PUNCT
gs-3799	420	8	ultrafiltration	ultrafiltration	NOUN
gs-3799	420	9	,	,	PUNCT
gs-3799	420	10	or	or	CCONJ
gs-3799	420	11	corticosteroid	corticosteroid	ADJ
gs-3799	420	12	infusion	infusion	NOUN
gs-3799	420	13	in	in	ADP
gs-3799	420	14	response	response	NOUN
gs-3799	420	15	to	to	ADP
gs-3799	420	16	these	these	DET
gs-3799	420	17	biomarkers	biomarker	NOUN
gs-3799	420	18	promises	promise	VERB
gs-3799	420	19	a	a	DET
gs-3799	420	20	new	new	ADJ
gs-3799	420	21	layer	layer	NOUN
gs-3799	420	22	of	of	ADP
gs-3799	420	23	bio	bio	NOUN
gs-3799	420	24	-	-	NOUN
gs-3799	420	25	adaptivity	adaptivity	NOUN
gs-3799	420	26	.	.	PUNCT
gs-3799	421	1	for	for	ADP
gs-3799	421	2	example	example	NOUN
gs-3799	421	3	,	,	PUNCT
gs-3799	421	4	an	an	DET
gs-3799	421	5	increase	increase	NOUN
gs-3799	421	6	in	in	ADP
gs-3799	421	7	il-6	il-6	NUM
gs-3799	421	8	could	could	AUX
gs-3799	421	9	prompt	prompt	VERB
gs-3799	421	10	the	the	DET
gs-3799	421	11	system	system	NOUN
gs-3799	421	12	to	to	PART
gs-3799	421	13	initiate	initiate	VERB
gs-3799	421	14	or	or	CCONJ
gs-3799	421	15	escalate	escalate	VERB
gs-3799	421	16	anti	anti	ADJ
gs-3799	421	17	-	-	ADJ
gs-3799	421	18	inflammatory	inflammatory	ADJ
gs-3799	421	19	treatment	treatment	NOUN
gs-3799	421	20	,	,	PUNCT
gs-3799	421	21	while	while	SCONJ
gs-3799	421	22	rising	rise	VERB
gs-3799	421	23	troponin	troponin	ADJ
gs-3799	421	24	levels	level	NOUN
gs-3799	421	25	might	might	AUX
gs-3799	421	26	trigger	trigger	VERB
gs-3799	421	27	a	a	DET
gs-3799	421	28	myocardial	myocardial	ADJ
gs-3799	421	29	protection	protection	NOUN
gs-3799	421	30	protocol	protocol	NOUN
gs-3799	421	31	.	.	PUNCT
gs-3799	422	1	this	this	DET
gs-3799	422	2	biologically	biologically	ADV
gs-3799	422	3	responsive	responsive	ADJ
gs-3799	422	4	automation	automation	NOUN
gs-3799	422	5	pushes	push	VERB
gs-3799	422	6	cpb	cpb	PROPN
gs-3799	422	7	management	management	PROPN
gs-3799	422	8	closer	close	ADV
gs-3799	422	9	to	to	ADP
gs-3799	422	10	an	an	DET
gs-3799	422	11	intelligent	intelligent	ADJ
gs-3799	422	12	,	,	PUNCT
gs-3799	422	13	real	real	ADJ
gs-3799	422	14	-	-	PUNCT
gs-3799	422	15	time	time	NOUN
gs-3799	422	16	therapeutic	therapeutic	ADJ
gs-3799	422	17	platform	platform	NOUN
gs-3799	422	18	.	.	PUNCT
gs-3799	423	1	from	from	ADP
gs-3799	423	2	a	a	DET
gs-3799	423	3	systems	system	NOUN
gs-3799	423	4	engineering	engineering	NOUN
gs-3799	423	5	perspective	perspective	NOUN
gs-3799	423	6	,	,	PUNCT
gs-3799	423	7	the	the	DET
gs-3799	423	8	integration	integration	NOUN
gs-3799	423	9	of	of	ADP
gs-3799	423	10	closed	closed	ADJ
gs-3799	423	11	-	-	PUNCT
gs-3799	423	12	loop	loop	NOUN
gs-3799	423	13	cpb	cpb	NOUN
gs-3799	423	14	into	into	ADP
gs-3799	423	15	the	the	DET
gs-3799	423	16	broader	broad	ADJ
gs-3799	423	17	operating	operating	NOUN
gs-3799	423	18	room	room	NOUN
gs-3799	423	19	environment	environment	NOUN
gs-3799	423	20	raises	raise	VERB
gs-3799	423	21	important	important	ADJ
gs-3799	423	22	interoperability	interoperability	NOUN
gs-3799	423	23	and	and	CCONJ
gs-3799	423	24	workflow	workflow	NOUN
gs-3799	423	25	considerations	consideration	NOUN
gs-3799	423	26	.	.	PUNCT
gs-3799	424	1	successful	successful	ADJ
gs-3799	424	2	implementation	implementation	NOUN
gs-3799	424	3	depends	depend	VERB
gs-3799	424	4	on	on	ADP
gs-3799	424	5	harmonizing	harmonize	VERB
gs-3799	424	6	these	these	DET
gs-3799	424	7	systems	system	NOUN
gs-3799	424	8	with	with	ADP
gs-3799	424	9	anesthesia	anesthesia	NOUN
gs-3799	424	10	monitors	monitor	NOUN
gs-3799	424	11	,	,	PUNCT
gs-3799	424	12	ventilators	ventilator	NOUN
gs-3799	424	13	,	,	PUNCT
gs-3799	424	14	surgical	surgical	ADJ
gs-3799	424	15	consoles	console	NOUN
gs-3799	424	16	,	,	PUNCT
gs-3799	424	17	and	and	CCONJ
gs-3799	424	18	electronic	electronic	ADJ
gs-3799	424	19	health	health	NOUN
gs-3799	424	20	records	record	NOUN
gs-3799	424	21	.	.	PUNCT
gs-3799	425	1	middleware	middleware	NOUN
gs-3799	425	2	platforms	platform	NOUN
gs-3799	425	3	capable	capable	ADJ
gs-3799	425	4	of	of	ADP
gs-3799	425	5	aggregating	aggregate	VERB
gs-3799	425	6	and	and	CCONJ
gs-3799	425	7	translating	translate	VERB
gs-3799	425	8	data	datum	NOUN
gs-3799	425	9	across	across	ADP
gs-3799	425	10	heterogeneous	heterogeneous	ADJ
gs-3799	425	11	systems	system	NOUN
gs-3799	425	12	are	be	AUX
gs-3799	425	13	being	be	AUX
gs-3799	425	14	developed	develop	VERB
gs-3799	425	15	to	to	PART
gs-3799	425	16	ensure	ensure	VERB
gs-3799	425	17	seamless	seamless	ADJ
gs-3799	425	18	communication	communication	NOUN
gs-3799	425	19	.	.	PUNCT
gs-3799	426	1	the	the	DET
gs-3799	426	2	goal	goal	NOUN
gs-3799	426	3	is	be	AUX
gs-3799	426	4	to	to	PART
gs-3799	426	5	create	create	VERB
gs-3799	426	6	a	a	DET
gs-3799	426	7	unified	unified	ADJ
gs-3799	426	8	intraoperative	intraoperative	ADJ
gs-3799	426	9	command	command	NOUN
gs-3799	426	10	center	center	NOUN
gs-3799	426	11	wherein	wherein	ADJ
gs-3799	426	12	closed	closed	ADJ
gs-3799	426	13	-	-	PUNCT
gs-3799	426	14	loop	loop	NOUN
gs-3799	426	15	modules	module	NOUN
gs-3799	426	16	contribute	contribute	VERB
gs-3799	426	17	data	datum	NOUN
gs-3799	426	18	to	to	PART
gs-3799	426	19	and	and	CCONJ
gs-3799	426	20	receive	receive	VERB
gs-3799	426	21	commands	command	NOUN
gs-3799	426	22	from	from	ADP
gs-3799	426	23	a	a	DET
gs-3799	426	24	central	central	ADJ
gs-3799	426	25	surgical	surgical	ADJ
gs-3799	426	26	intelligence	intelligence	NOUN
gs-3799	426	27	hub	hub	NOUN
gs-3799	426	28	.	.	PUNCT
gs-3799	427	1	such	such	ADJ
gs-3799	427	2	environments	environment	NOUN
gs-3799	427	3	are	be	AUX
gs-3799	427	4	particularly	particularly	ADV
gs-3799	427	5	advantageous	advantageous	ADJ
gs-3799	427	6	in	in	ADP
gs-3799	427	7	hybrid	hybrid	ADJ
gs-3799	427	8	operating	operating	NOUN
gs-3799	427	9	rooms	room	NOUN
gs-3799	427	10	and	and	CCONJ
gs-3799	427	11	minimally	minimally	ADV
gs-3799	427	12	invasive	invasive	ADJ
gs-3799	427	13	cardiac	cardiac	ADJ
gs-3799	427	14	procedures	procedure	NOUN
gs-3799	427	15	where	where	SCONJ
gs-3799	427	16	real	real	ADJ
gs-3799	427	17	-	-	PUNCT
gs-3799	427	18	time	time	NOUN
gs-3799	427	19	synchronization	synchronization	NOUN
gs-3799	427	20	is	be	AUX
gs-3799	427	21	critical	critical	ADJ
gs-3799	427	22	.	.	PUNCT
gs-3799	428	1	the	the	DET
gs-3799	428	2	psychological	psychological	ADJ
gs-3799	428	3	impact	impact	NOUN
gs-3799	428	4	on	on	ADP
gs-3799	428	5	clinical	clinical	ADJ
gs-3799	428	6	teams	team	NOUN
gs-3799	428	7	must	must	AUX
gs-3799	428	8	also	also	ADV
gs-3799	428	9	be	be	AUX
gs-3799	428	10	considered	consider	VERB
gs-3799	428	11	.	.	PUNCT
gs-3799	429	1	transitioning	transition	VERB
gs-3799	429	2	from	from	ADP
gs-3799	429	3	manual	manual	NOUN
gs-3799	429	4	to	to	ADP
gs-3799	429	5	automated	automate	VERB
gs-3799	429	6	systems	system	NOUN
gs-3799	429	7	requires	require	VERB
gs-3799	429	8	a	a	DET
gs-3799	429	9	cultural	cultural	ADJ
gs-3799	429	10	shift	shift	NOUN
gs-3799	429	11	,	,	PUNCT
gs-3799	429	12	particularly	particularly	ADV
gs-3799	429	13	for	for	ADP
gs-3799	429	14	perfusionists	perfusionist	NOUN
gs-3799	429	15	whose	whose	DET
gs-3799	429	16	roles	role	NOUN
gs-3799	429	17	are	be	AUX
gs-3799	429	18	deeply	deeply	ADV
gs-3799	429	19	embedded	embed	VERB
gs-3799	429	20	in	in	ADP
gs-3799	429	21	manual	manual	ADJ
gs-3799	429	22	control	control	NOUN
gs-3799	429	23	and	and	CCONJ
gs-3799	429	24	real	real	ADJ
gs-3799	429	25	-	-	PUNCT
gs-3799	429	26	time	time	NOUN
gs-3799	429	27	decision	decision	NOUN
gs-3799	429	28	-	-	PUNCT
gs-3799	429	29	making	making	NOUN
gs-3799	429	30	.	.	PUNCT
gs-3799	430	1	studies	study	NOUN
gs-3799	430	2	show	show	VERB
gs-3799	430	3	that	that	SCONJ
gs-3799	430	4	while	while	SCONJ
gs-3799	430	5	automation	automation	NOUN
gs-3799	430	6	reduces	reduce	VERB
gs-3799	430	7	fatigue	fatigue	NOUN
gs-3799	430	8	and	and	CCONJ
gs-3799	430	9	enhances	enhance	VERB
gs-3799	430	10	consistency	consistency	NOUN
gs-3799	430	11	,	,	PUNCT
gs-3799	430	12	it	it	PRON
gs-3799	430	13	also	also	ADV
gs-3799	430	14	introduces	introduce	VERB
gs-3799	430	15	concerns	concern	NOUN
gs-3799	430	16	about	about	ADP
gs-3799	430	17	skill	skill	NOUN
gs-3799	430	18	erosion	erosion	NOUN
gs-3799	430	19	,	,	PUNCT
gs-3799	430	20	loss	loss	NOUN
gs-3799	430	21	of	of	ADP
gs-3799	430	22	autonomy	autonomy	NOUN
gs-3799	430	23	,	,	PUNCT
gs-3799	430	24	and	and	CCONJ
gs-3799	430	25	overreliance	overreliance	NOUN
gs-3799	430	26	on	on	ADP
gs-3799	430	27	system	system	NOUN
gs-3799	430	28	recommendations	recommendation	NOUN
gs-3799	430	29	.	.	PUNCT
gs-3799	431	1	human	human	ADJ
gs-3799	431	2	-	-	PUNCT
gs-3799	431	3	machine	machine	NOUN
gs-3799	431	4	interface	interface	NOUN
gs-3799	431	5	(	(	PUNCT
gs-3799	431	6	hmi	hmi	PROPN
gs-3799	431	7	)	)	PUNCT
gs-3799	431	8	design	design	NOUN
gs-3799	431	9	has	have	AUX
gs-3799	431	10	therefore	therefore	ADV
gs-3799	431	11	become	become	VERB
gs-3799	431	12	a	a	DET
gs-3799	431	13	central	central	ADJ
gs-3799	431	14	theme	theme	NOUN
gs-3799	431	15	in	in	ADP
gs-3799	431	16	closed	closed	ADJ
gs-3799	431	17	-	-	PUNCT
gs-3799	431	18	loop	loop	NOUN
gs-3799	431	19	system	system	NOUN
gs-3799	431	20	development	development	NOUN
gs-3799	431	21	.	.	PUNCT
gs-3799	432	1	dashboards	dashboard	NOUN
gs-3799	432	2	that	that	PRON
gs-3799	432	3	maintain	maintain	VERB
gs-3799	432	4	transparency	transparency	NOUN
gs-3799	432	5	of	of	ADP
gs-3799	432	6	system	system	NOUN
gs-3799	432	7	logic	logic	NOUN
gs-3799	432	8	,	,	PUNCT
gs-3799	432	9	visualize	visualize	VERB
gs-3799	432	10	risk	risk	NOUN
gs-3799	432	11	thresholds	threshold	NOUN
gs-3799	432	12	,	,	PUNCT
gs-3799	432	13	and	and	CCONJ
gs-3799	432	14	provide	provide	VERB
gs-3799	432	15	tactile	tactile	ADJ
gs-3799	432	16	or	or	CCONJ
gs-3799	432	17	auditory	auditory	ADJ
gs-3799	432	18	alerts	alert	NOUN
gs-3799	432	19	are	be	AUX
gs-3799	432	20	shown	show	VERB
gs-3799	432	21	to	to	PART
gs-3799	432	22	enhance	enhance	VERB
gs-3799	432	23	operator	operator	NOUN
gs-3799	432	24	trust	trust	NOUN
gs-3799	432	25	and	and	CCONJ
gs-3799	432	26	reduce	reduce	VERB
gs-3799	432	27	response	response	NOUN
gs-3799	432	28	latency	latency	NOUN
gs-3799	432	29	.	.	PUNCT
gs-3799	433	1	training	training	NOUN
gs-3799	433	2	programs	program	NOUN
gs-3799	433	3	that	that	PRON
gs-3799	433	4	combine	combine	VERB
gs-3799	433	5	simulationbased	simulationbase	VERB
gs-3799	433	6	practice	practice	NOUN
gs-3799	433	7	with	with	ADP
gs-3799	433	8	live	live	ADJ
gs-3799	433	9	feedback	feedback	NOUN
gs-3799	433	10	on	on	ADP
gs-3799	433	11	human	human	ADJ
gs-3799	433	12	-	-	PUNCT
gs-3799	433	13	system	system	NOUN
gs-3799	433	14	interaction	interaction	NOUN
gs-3799	433	15	are	be	AUX
gs-3799	433	16	proving	prove	VERB
gs-3799	433	17	essential	essential	ADJ
gs-3799	433	18	in	in	ADP
gs-3799	433	19	bridging	bridge	VERB
gs-3799	433	20	this	this	DET
gs-3799	433	21	cultural	cultural	ADJ
gs-3799	433	22	and	and	CCONJ
gs-3799	433	23	operational	operational	ADJ
gs-3799	433	24	gap	gap	NOUN
gs-3799	433	25	.	.	PUNCT
gs-3799	434	1	georgian	georgian	NOUN
gs-3799	434	2	scientists/	scientists/	NUM
gs-3799	434	3	.	.	PUNCT
gs-3799	435	1	7	7	NUM
gs-3799	435	2	n	n	PRON
gs-3799	435	3	2	2	NUM
gs-3799	435	4	,	,	PUNCT
gs-3799	435	5	2025	2025	NUM
gs-3799	435	6	402	402	NUM
gs-3799	435	7	furthermore	furthermore	ADV
gs-3799	435	8	,	,	PUNCT
gs-3799	435	9	the	the	DET
gs-3799	435	10	ethical	ethical	ADJ
gs-3799	435	11	landscape	landscape	NOUN
gs-3799	435	12	of	of	ADP
gs-3799	435	13	closed	closed	ADJ
gs-3799	435	14	-	-	PUNCT
gs-3799	435	15	loop	loop	NOUN
gs-3799	435	16	cpb	cpb	NOUN
gs-3799	435	17	must	must	AUX
gs-3799	435	18	evolve	evolve	VERB
gs-3799	435	19	in	in	ADP
gs-3799	435	20	parallel	parallel	NOUN
gs-3799	435	21	with	with	ADP
gs-3799	435	22	technological	technological	ADJ
gs-3799	435	23	progress	progress	NOUN
gs-3799	435	24	.	.	PUNCT
gs-3799	436	1	the	the	DET
gs-3799	436	2	notion	notion	NOUN
gs-3799	436	3	of	of	ADP
gs-3799	436	4	informed	informed	ADJ
gs-3799	436	5	consent	consent	NOUN
gs-3799	436	6	becomes	become	VERB
gs-3799	436	7	more	more	ADV
gs-3799	436	8	complex	complex	ADJ
gs-3799	436	9	when	when	SCONJ
gs-3799	436	10	describing	describe	VERB
gs-3799	436	11	an	an	DET
gs-3799	436	12	automated	automate	VERB
gs-3799	436	13	system	system	NOUN
gs-3799	436	14	that	that	PRON
gs-3799	436	15	may	may	AUX
gs-3799	436	16	make	make	VERB
gs-3799	436	17	hundreds	hundred	NOUN
gs-3799	436	18	of	of	ADP
gs-3799	436	19	decisions	decision	NOUN
gs-3799	436	20	per	per	ADP
gs-3799	436	21	hour	hour	NOUN
gs-3799	436	22	with	with	ADP
gs-3799	436	23	minimal	minimal	ADJ
gs-3799	436	24	human	human	ADJ
gs-3799	436	25	intervention	intervention	NOUN
gs-3799	436	26	.	.	PUNCT
gs-3799	437	1	efforts	effort	NOUN
gs-3799	437	2	to	to	PART
gs-3799	437	3	develop	develop	VERB
gs-3799	437	4	patient	patient	NOUN
gs-3799	437	5	-	-	PUNCT
gs-3799	437	6	friendly	friendly	ADJ
gs-3799	437	7	explanatory	explanatory	ADJ
gs-3799	437	8	frameworks	framework	NOUN
gs-3799	437	9	and	and	CCONJ
gs-3799	437	10	visual	visual	ADJ
gs-3799	437	11	aids	aid	NOUN
gs-3799	437	12	that	that	PRON
gs-3799	437	13	clarify	clarify	VERB
gs-3799	437	14	how	how	SCONJ
gs-3799	437	15	closed	closed	ADJ
gs-3799	437	16	-	-	PUNCT
gs-3799	437	17	loop	loop	NOUN
gs-3799	437	18	systems	system	NOUN
gs-3799	437	19	function	function	NOUN
gs-3799	437	20	—	—	PUNCT
gs-3799	437	21	and	and	CCONJ
gs-3799	437	22	what	what	PRON
gs-3799	437	23	risks	risk	NOUN
gs-3799	437	24	are	be	AUX
gs-3799	437	25	associated	associate	VERB
gs-3799	437	26	—	—	PUNCT
gs-3799	437	27	are	be	AUX
gs-3799	437	28	underway	underway	ADJ
gs-3799	437	29	.	.	PUNCT
gs-3799	438	1	in	in	ADP
gs-3799	438	2	academic	academic	ADJ
gs-3799	438	3	institutions	institution	NOUN
gs-3799	438	4	,	,	PUNCT
gs-3799	438	5	ethics	ethic	NOUN
gs-3799	438	6	boards	board	NOUN
gs-3799	438	7	are	be	AUX
gs-3799	438	8	now	now	ADV
gs-3799	438	9	tasked	task	VERB
gs-3799	438	10	with	with	ADP
gs-3799	438	11	evaluating	evaluate	VERB
gs-3799	438	12	the	the	DET
gs-3799	438	13	transparency	transparency	NOUN
gs-3799	438	14	,	,	PUNCT
gs-3799	438	15	safety	safety	NOUN
gs-3799	438	16	,	,	PUNCT
gs-3799	438	17	and	and	CCONJ
gs-3799	438	18	equity	equity	NOUN
gs-3799	438	19	of	of	ADP
gs-3799	438	20	algorithms	algorithm	NOUN
gs-3799	438	21	used	use	VERB
gs-3799	438	22	in	in	ADP
gs-3799	438	23	critical	critical	ADJ
gs-3799	438	24	care	care	NOUN
gs-3799	438	25	automation	automation	NOUN
gs-3799	438	26	.	.	PUNCT
gs-3799	439	1	this	this	PRON
gs-3799	439	2	includes	include	VERB
gs-3799	439	3	assessing	assess	VERB
gs-3799	439	4	algorithmic	algorithmic	ADJ
gs-3799	439	5	bias	bias	NOUN
gs-3799	439	6	,	,	PUNCT
gs-3799	439	7	especially	especially	ADV
gs-3799	439	8	as	as	SCONJ
gs-3799	439	9	data	datum	NOUN
gs-3799	439	10	sources	source	NOUN
gs-3799	439	11	may	may	AUX
gs-3799	439	12	underrepresent	underrepresent	VERB
gs-3799	439	13	minorities	minority	NOUN
gs-3799	439	14	or	or	CCONJ
gs-3799	439	15	rare	rare	ADJ
gs-3799	439	16	pathologies	pathology	NOUN
gs-3799	439	17	,	,	PUNCT
gs-3799	439	18	leading	lead	VERB
gs-3799	439	19	to	to	AUX
gs-3799	439	20	differential	differential	VERB
gs-3799	439	21	outcomes	outcome	NOUN
gs-3799	439	22	in	in	ADP
gs-3799	439	23	practice	practice	NOUN
gs-3799	439	24	.	.	PUNCT
gs-3799	440	1	the	the	DET
gs-3799	440	2	long	long	ADJ
gs-3799	440	3	-	-	PUNCT
gs-3799	440	4	term	term	NOUN
gs-3799	440	5	implications	implication	NOUN
gs-3799	440	6	of	of	ADP
gs-3799	440	7	closed	closed	ADJ
gs-3799	440	8	-	-	PUNCT
gs-3799	440	9	loop	loop	NOUN
gs-3799	440	10	systems	system	NOUN
gs-3799	440	11	extend	extend	VERB
gs-3799	440	12	into	into	ADP
gs-3799	440	13	postoperative	postoperative	ADJ
gs-3799	440	14	care	care	NOUN
gs-3799	440	15	,	,	PUNCT
gs-3799	440	16	where	where	SCONJ
gs-3799	440	17	data	datum	NOUN
gs-3799	440	18	collected	collect	VERB
gs-3799	440	19	during	during	ADP
gs-3799	440	20	cpb	cpb	NOUN
gs-3799	440	21	can	can	AUX
gs-3799	440	22	be	be	AUX
gs-3799	440	23	used	use	VERB
gs-3799	440	24	to	to	PART
gs-3799	440	25	inform	inform	VERB
gs-3799	440	26	icu	icu	ADJ
gs-3799	440	27	strategies	strategy	NOUN
gs-3799	440	28	.	.	PUNCT
gs-3799	441	1	for	for	ADP
gs-3799	441	2	example	example	NOUN
gs-3799	441	3	,	,	PUNCT
gs-3799	441	4	predictive	predictive	ADJ
gs-3799	441	5	analytics	analytic	NOUN
gs-3799	441	6	derived	derive	VERB
gs-3799	441	7	from	from	ADP
gs-3799	441	8	intraoperative	intraoperative	ADJ
gs-3799	441	9	stability	stability	NOUN
gs-3799	441	10	profiles	profile	NOUN
gs-3799	441	11	may	may	AUX
gs-3799	441	12	help	help	VERB
gs-3799	441	13	stratify	stratify	VERB
gs-3799	441	14	patients	patient	NOUN
gs-3799	441	15	by	by	ADP
gs-3799	441	16	risk	risk	NOUN
gs-3799	441	17	of	of	ADP
gs-3799	441	18	respiratory	respiratory	ADJ
gs-3799	441	19	failure	failure	NOUN
gs-3799	441	20	,	,	PUNCT
gs-3799	441	21	delirium	delirium	NOUN
gs-3799	441	22	,	,	PUNCT
gs-3799	441	23	or	or	CCONJ
gs-3799	441	24	organ	organ	NOUN
gs-3799	441	25	dysfunction	dysfunction	NOUN
gs-3799	441	26	.	.	PUNCT
gs-3799	442	1	integration	integration	NOUN
gs-3799	442	2	of	of	ADP
gs-3799	442	3	this	this	DET
gs-3799	442	4	data	datum	NOUN
gs-3799	442	5	into	into	ADP
gs-3799	442	6	postoperative	postoperative	ADJ
gs-3799	442	7	monitoring	monitoring	NOUN
gs-3799	442	8	algorithms	algorithm	NOUN
gs-3799	442	9	enables	enable	VERB
gs-3799	442	10	continuity	continuity	NOUN
gs-3799	442	11	of	of	ADP
gs-3799	442	12	care	care	NOUN
gs-3799	442	13	across	across	ADP
gs-3799	442	14	the	the	DET
gs-3799	442	15	perioperative	perioperative	ADJ
gs-3799	442	16	spectrum	spectrum	NOUN
gs-3799	442	17	.	.	PUNCT
gs-3799	443	1	in	in	ADP
gs-3799	443	2	this	this	DET
gs-3799	443	3	context	context	NOUN
gs-3799	443	4	,	,	PUNCT
gs-3799	443	5	the	the	DET
gs-3799	443	6	cpb	cpb	NOUN
gs-3799	443	7	system	system	NOUN
gs-3799	443	8	acts	act	VERB
gs-3799	443	9	as	as	ADP
gs-3799	443	10	both	both	CCONJ
gs-3799	443	11	a	a	DET
gs-3799	443	12	lifesupport	lifesupport	PROPN
gs-3799	443	13	modality	modality	NOUN
gs-3799	443	14	and	and	CCONJ
gs-3799	443	15	a	a	DET
gs-3799	443	16	diagnostic	diagnostic	ADJ
gs-3799	443	17	tool	tool	NOUN
gs-3799	443	18	,	,	PUNCT
gs-3799	443	19	generating	generate	VERB
gs-3799	443	20	valuable	valuable	ADJ
gs-3799	443	21	prognostic	prognostic	ADJ
gs-3799	443	22	insight	insight	NOUN
gs-3799	443	23	that	that	PRON
gs-3799	443	24	extends	extend	VERB
gs-3799	443	25	beyond	beyond	ADP
gs-3799	443	26	the	the	DET
gs-3799	443	27	operating	operating	NOUN
gs-3799	443	28	room	room	NOUN
gs-3799	443	29	.	.	PUNCT
gs-3799	444	1	innovation	innovation	NOUN
gs-3799	444	2	in	in	ADP
gs-3799	444	3	biocompatibility	biocompatibility	NOUN
gs-3799	444	4	is	be	AUX
gs-3799	444	5	another	another	DET
gs-3799	444	6	frontier	frontier	NOUN
gs-3799	444	7	in	in	ADP
gs-3799	444	8	the	the	DET
gs-3799	444	9	evolution	evolution	NOUN
gs-3799	444	10	of	of	ADP
gs-3799	444	11	closed	closed	ADJ
gs-3799	444	12	-	-	PUNCT
gs-3799	444	13	loop	loop	NOUN
gs-3799	444	14	systems	system	NOUN
gs-3799	444	15	.	.	PUNCT
gs-3799	445	1	the	the	DET
gs-3799	445	2	materials	material	NOUN
gs-3799	445	3	used	use	VERB
gs-3799	445	4	in	in	ADP
gs-3799	445	5	circuit	circuit	NOUN
gs-3799	445	6	tubing	tubing	NOUN
gs-3799	445	7	,	,	PUNCT
gs-3799	445	8	oxygenators	oxygenator	NOUN
gs-3799	445	9	,	,	PUNCT
gs-3799	445	10	and	and	CCONJ
gs-3799	445	11	filters	filter	VERB
gs-3799	445	12	influence	influence	NOUN
gs-3799	445	13	not	not	PART
gs-3799	445	14	only	only	ADV
gs-3799	445	15	hemocompatibility	hemocompatibility	NOUN
gs-3799	445	16	but	but	CCONJ
gs-3799	445	17	also	also	ADV
gs-3799	445	18	the	the	DET
gs-3799	445	19	accuracy	accuracy	NOUN
gs-3799	445	20	of	of	ADP
gs-3799	445	21	biosensor	biosensor	NOUN
gs-3799	445	22	data	datum	NOUN
gs-3799	445	23	.	.	PUNCT
gs-3799	446	1	surface	surface	NOUN
gs-3799	446	2	-	-	PUNCT
gs-3799	446	3	modified	modify	VERB
gs-3799	446	4	polymers	polymer	NOUN
gs-3799	446	5	and	and	CCONJ
gs-3799	446	6	smart	smart	ADJ
gs-3799	446	7	coatings	coating	NOUN
gs-3799	446	8	that	that	PRON
gs-3799	446	9	resist	resist	VERB
gs-3799	446	10	protein	protein	NOUN
gs-3799	446	11	adsorption	adsorption	NOUN
gs-3799	446	12	,	,	PUNCT
gs-3799	446	13	platelet	platelet	NOUN
gs-3799	446	14	activation	activation	NOUN
gs-3799	446	15	,	,	PUNCT
gs-3799	446	16	and	and	CCONJ
gs-3799	446	17	inflammatory	inflammatory	ADJ
gs-3799	446	18	priming	priming	NOUN
gs-3799	446	19	are	be	AUX
gs-3799	446	20	being	be	AUX
gs-3799	446	21	developed	develop	VERB
gs-3799	446	22	.	.	PUNCT
gs-3799	447	1	these	these	DET
gs-3799	447	2	materials	material	NOUN
gs-3799	447	3	reduce	reduce	VERB
gs-3799	447	4	noise	noise	NOUN
gs-3799	447	5	in	in	ADP
gs-3799	447	6	sensor	sensor	NOUN
gs-3799	447	7	output	output	NOUN
gs-3799	447	8	and	and	CCONJ
gs-3799	447	9	improve	improve	VERB
gs-3799	447	10	the	the	DET
gs-3799	447	11	fidelity	fidelity	NOUN
gs-3799	447	12	of	of	ADP
gs-3799	447	13	control	control	NOUN
gs-3799	447	14	algorithms	algorithm	NOUN
gs-3799	447	15	,	,	PUNCT
gs-3799	447	16	which	which	PRON
gs-3799	447	17	depend	depend	VERB
gs-3799	447	18	on	on	ADP
gs-3799	447	19	real	real	ADJ
gs-3799	447	20	-	-	PUNCT
gs-3799	447	21	time	time	NOUN
gs-3799	447	22	,	,	PUNCT
gs-3799	447	23	uncorrupted	uncorrupted	ADJ
gs-3799	447	24	data	datum	NOUN
gs-3799	447	25	streams	stream	NOUN
gs-3799	447	26	to	to	PART
gs-3799	447	27	function	function	VERB
gs-3799	447	28	effectively	effectively	ADV
gs-3799	447	29	.	.	PUNCT
gs-3799	448	1	coupled	couple	VERB
gs-3799	448	2	with	with	ADP
gs-3799	448	3	nanotechnology	nanotechnology	NOUN
gs-3799	448	4	-	-	PUNCT
gs-3799	448	5	enhanced	enhance	VERB
gs-3799	448	6	sensor	sensor	NOUN
gs-3799	448	7	arrays	array	VERB
gs-3799	448	8	,	,	PUNCT
gs-3799	448	9	these	these	DET
gs-3799	448	10	innovations	innovation	NOUN
gs-3799	448	11	enhance	enhance	VERB
gs-3799	448	12	the	the	DET
gs-3799	448	13	precision	precision	NOUN
gs-3799	448	14	and	and	CCONJ
gs-3799	448	15	responsiveness	responsiveness	NOUN
gs-3799	448	16	of	of	ADP
gs-3799	448	17	closed	closed	ADJ
gs-3799	448	18	-	-	PUNCT
gs-3799	448	19	loop	loop	NOUN
gs-3799	448	20	interventions	intervention	NOUN
gs-3799	448	21	.	.	PUNCT
gs-3799	449	1	finally	finally	ADV
gs-3799	449	2	,	,	PUNCT
gs-3799	449	3	the	the	DET
gs-3799	449	4	globalization	globalization	NOUN
gs-3799	449	5	of	of	ADP
gs-3799	449	6	surgical	surgical	ADJ
gs-3799	449	7	technology	technology	NOUN
gs-3799	449	8	introduces	introduce	VERB
gs-3799	449	9	a	a	DET
gs-3799	449	10	set	set	NOUN
gs-3799	449	11	of	of	ADP
gs-3799	449	12	logistical	logistical	ADJ
gs-3799	449	13	and	and	CCONJ
gs-3799	449	14	socioeconomic	socioeconomic	ADJ
gs-3799	449	15	considerations	consideration	NOUN
gs-3799	449	16	for	for	ADP
gs-3799	449	17	closed	closed	ADJ
gs-3799	449	18	-	-	PUNCT
gs-3799	449	19	loop	loop	NOUN
gs-3799	449	20	cpb	cpb	NOUN
gs-3799	449	21	.	.	PUNCT
gs-3799	450	1	in	in	ADP
gs-3799	450	2	high	high	ADJ
gs-3799	450	3	-	-	PUNCT
gs-3799	450	4	resource	resource	NOUN
gs-3799	450	5	settings	setting	NOUN
gs-3799	450	6	,	,	PUNCT
gs-3799	450	7	adoption	adoption	NOUN
gs-3799	450	8	may	may	AUX
gs-3799	450	9	be	be	AUX
gs-3799	450	10	driven	drive	VERB
gs-3799	450	11	by	by	ADP
gs-3799	450	12	goals	goal	NOUN
gs-3799	450	13	of	of	ADP
gs-3799	450	14	precision	precision	NOUN
gs-3799	450	15	and	and	CCONJ
gs-3799	450	16	standardization	standardization	NOUN
gs-3799	450	17	.	.	PUNCT
gs-3799	451	1	in	in	ADP
gs-3799	451	2	contrast	contrast	NOUN
gs-3799	451	3	,	,	PUNCT
gs-3799	451	4	in	in	ADP
gs-3799	451	5	lowand	lowand	ADJ
gs-3799	451	6	middle	middle	ADJ
gs-3799	451	7	-	-	PUNCT
gs-3799	451	8	income	income	NOUN
gs-3799	451	9	countries	country	NOUN
gs-3799	451	10	,	,	PUNCT
gs-3799	451	11	the	the	DET
gs-3799	451	12	same	same	ADJ
gs-3799	451	13	systems	system	NOUN
gs-3799	451	14	may	may	AUX
gs-3799	451	15	be	be	AUX
gs-3799	451	16	valued	value	VERB
gs-3799	451	17	for	for	ADP
gs-3799	451	18	their	their	PRON
gs-3799	451	19	ability	ability	NOUN
gs-3799	451	20	to	to	PART
gs-3799	451	21	reduce	reduce	VERB
gs-3799	451	22	clinician	clinician	ADJ
gs-3799	451	23	workload	workload	NOUN
gs-3799	451	24	,	,	PUNCT
gs-3799	451	25	prevent	prevent	VERB
gs-3799	451	26	errors	error	NOUN
gs-3799	451	27	,	,	PUNCT
gs-3799	451	28	and	and	CCONJ
gs-3799	451	29	extend	extend	VERB
gs-3799	451	30	access	access	NOUN
gs-3799	451	31	to	to	ADP
gs-3799	451	32	safe	safe	ADJ
gs-3799	451	33	surgery	surgery	NOUN
gs-3799	451	34	in	in	ADP
gs-3799	451	35	settings	setting	NOUN
gs-3799	451	36	where	where	SCONJ
gs-3799	451	37	perfusion	perfusion	NOUN
gs-3799	451	38	expertise	expertise	NOUN
gs-3799	451	39	is	be	AUX
gs-3799	451	40	scarce	scarce	ADJ
gs-3799	451	41	.	.	PUNCT
gs-3799	452	1	modular	modular	ADJ
gs-3799	452	2	and	and	CCONJ
gs-3799	452	3	portable	portable	ADJ
gs-3799	452	4	versions	version	NOUN
gs-3799	452	5	of	of	ADP
gs-3799	452	6	closed	closed	ADJ
gs-3799	452	7	-	-	PUNCT
gs-3799	452	8	loop	loop	NOUN
gs-3799	452	9	systems	system	NOUN
gs-3799	452	10	are	be	AUX
gs-3799	452	11	under	under	ADP
gs-3799	452	12	development	development	NOUN
gs-3799	452	13	for	for	ADP
gs-3799	452	14	deployment	deployment	NOUN
gs-3799	452	15	in	in	ADP
gs-3799	452	16	remote	remote	ADJ
gs-3799	452	17	hospitals	hospital	NOUN
gs-3799	452	18	,	,	PUNCT
gs-3799	452	19	field	field	NOUN
gs-3799	452	20	units	unit	NOUN
gs-3799	452	21	,	,	PUNCT
gs-3799	452	22	and	and	CCONJ
gs-3799	452	23	humanitarian	humanitarian	ADJ
gs-3799	452	24	surgical	surgical	ADJ
gs-3799	452	25	missions	mission	NOUN
gs-3799	452	26	.	.	PUNCT
gs-3799	453	1	the	the	DET
gs-3799	453	2	democratization	democratization	NOUN
gs-3799	453	3	of	of	ADP
gs-3799	453	4	such	such	ADJ
gs-3799	453	5	advanced	advanced	ADJ
gs-3799	453	6	technologies	technology	NOUN
gs-3799	453	7	,	,	PUNCT
gs-3799	453	8	supported	support	VERB
gs-3799	453	9	by	by	ADP
gs-3799	453	10	scalable	scalable	ADJ
gs-3799	453	11	training	training	NOUN
gs-3799	453	12	programs	program	NOUN
gs-3799	453	13	and	and	CCONJ
gs-3799	453	14	remote	remote	ADJ
gs-3799	453	15	monitoring	monitoring	NOUN
gs-3799	453	16	,	,	PUNCT
gs-3799	453	17	could	could	AUX
gs-3799	453	18	redefine	redefine	VERB
gs-3799	453	19	the	the	DET
gs-3799	453	20	global	global	ADJ
gs-3799	453	21	landscape	landscape	NOUN
gs-3799	453	22	of	of	ADP
gs-3799	453	23	cardiac	cardiac	ADJ
gs-3799	453	24	surgery	surgery	NOUN
gs-3799	453	25	.	.	PUNCT
gs-3799	454	1	the	the	DET
gs-3799	454	2	maturation	maturation	NOUN
gs-3799	454	3	of	of	ADP
gs-3799	454	4	closed	closed	ADJ
gs-3799	454	5	-	-	PUNCT
gs-3799	454	6	loop	loop	NOUN
gs-3799	454	7	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	454	8	bypass	bypass	NOUN
gs-3799	454	9	(	(	PUNCT
gs-3799	454	10	cpb	cpb	NOUN
gs-3799	454	11	)	)	PUNCT
gs-3799	454	12	systems	system	NOUN
gs-3799	454	13	represents	represent	VERB
gs-3799	454	14	a	a	DET
gs-3799	454	15	critical	critical	ADJ
gs-3799	454	16	inflection	inflection	NOUN
gs-3799	454	17	point	point	NOUN
gs-3799	454	18	in	in	ADP
gs-3799	454	19	the	the	DET
gs-3799	454	20	evolution	evolution	NOUN
gs-3799	454	21	of	of	ADP
gs-3799	454	22	extracorporeal	extracorporeal	NOUN
gs-3799	454	23	support	support	NOUN
gs-3799	454	24	modalities	modality	NOUN
gs-3799	454	25	.	.	PUNCT
gs-3799	455	1	the	the	DET
gs-3799	455	2	current	current	ADJ
gs-3799	455	3	trajectory	trajectory	NOUN
gs-3799	455	4	of	of	ADP
gs-3799	455	5	innovation	innovation	NOUN
gs-3799	455	6	,	,	PUNCT
gs-3799	455	7	rooted	root	VERB
gs-3799	455	8	in	in	ADP
gs-3799	455	9	cyber	cyber	ADJ
gs-3799	455	10	-	-	PUNCT
gs-3799	455	11	physical	physical	ADJ
gs-3799	455	12	integration	integration	NOUN
gs-3799	455	13	and	and	CCONJ
gs-3799	455	14	real	real	ADJ
gs-3799	455	15	-	-	PUNCT
gs-3799	455	16	time	time	NOUN
gs-3799	455	17	biologic	biologic	NOUN
gs-3799	455	18	responsiveness	responsiveness	NOUN
gs-3799	455	19	,	,	PUNCT
gs-3799	455	20	introduces	introduce	VERB
gs-3799	455	21	a	a	DET
gs-3799	455	22	fundamentally	fundamentally	ADV
gs-3799	455	23	new	new	ADJ
gs-3799	455	24	paradigm	paradigm	NOUN
gs-3799	455	25	in	in	SCONJ
gs-3799	455	26	which	which	DET
gs-3799	455	27	patient	patient	NOUN
gs-3799	455	28	-	-	PUNCT
gs-3799	455	29	specific	specific	ADJ
gs-3799	455	30	feedback	feedback	NOUN
gs-3799	455	31	dynamically	dynamically	ADV
gs-3799	455	32	governs	govern	VERB
gs-3799	455	33	physiological	physiological	ADJ
gs-3799	455	34	parameters	parameter	NOUN
gs-3799	455	35	,	,	PUNCT
gs-3799	455	36	drug	drug	NOUN
gs-3799	455	37	administration	administration	NOUN
gs-3799	455	38	,	,	PUNCT
gs-3799	455	39	and	and	CCONJ
gs-3799	455	40	systemic	systemic	ADJ
gs-3799	455	41	perfusion	perfusion	NOUN
gs-3799	455	42	targets	target	NOUN
gs-3799	455	43	.	.	PUNCT
gs-3799	456	1	this	this	DET
gs-3799	456	2	new	new	ADJ
gs-3799	456	3	modality	modality	NOUN
gs-3799	456	4	departs	depart	VERB
gs-3799	456	5	from	from	ADP
gs-3799	456	6	conventional	conventional	ADJ
gs-3799	456	7	mechanistic	mechanistic	ADJ
gs-3799	456	8	management	management	NOUN
gs-3799	456	9	and	and	CCONJ
gs-3799	456	10	aligns	align	VERB
gs-3799	456	11	with	with	ADP
gs-3799	456	12	precision	precision	NOUN
gs-3799	456	13	medicine	medicine	NOUN
gs-3799	456	14	frameworks	framework	NOUN
gs-3799	456	15	,	,	PUNCT
gs-3799	456	16	underscoring	underscore	VERB
gs-3799	456	17	the	the	DET
gs-3799	456	18	need	need	NOUN
gs-3799	456	19	to	to	PART
gs-3799	456	20	re	re	VERB
gs-3799	456	21	-	-	VERB
gs-3799	456	22	evaluate	evaluate	VERB
gs-3799	456	23	outcome	outcome	NOUN
gs-3799	456	24	metrics	metric	NOUN
gs-3799	456	25	,	,	PUNCT
gs-3799	456	26	surgical	surgical	ADJ
gs-3799	456	27	processes	process	NOUN
gs-3799	456	28	,	,	PUNCT
gs-3799	456	29	and	and	CCONJ
gs-3799	456	30	long	long	ADJ
gs-3799	456	31	-	-	PUNCT
gs-3799	456	32	term	term	NOUN
gs-3799	456	33	patient	patient	NOUN
gs-3799	456	34	trajectories	trajectory	NOUN
gs-3799	456	35	.	.	PUNCT
gs-3799	457	1	a	a	DET
gs-3799	457	2	central	central	ADJ
gs-3799	457	3	feature	feature	NOUN
gs-3799	457	4	of	of	ADP
gs-3799	457	5	this	this	DET
gs-3799	457	6	transition	transition	NOUN
gs-3799	457	7	lies	lie	VERB
gs-3799	457	8	in	in	ADP
gs-3799	457	9	the	the	DET
gs-3799	457	10	architectural	architectural	ADJ
gs-3799	457	11	complexity	complexity	NOUN
gs-3799	457	12	of	of	ADP
gs-3799	457	13	next	next	ADJ
gs-3799	457	14	-	-	PUNCT
gs-3799	457	15	generation	generation	NOUN
gs-3799	457	16	closedloop	closedloop	NOUN
gs-3799	457	17	systems	system	NOUN
gs-3799	457	18	.	.	PUNCT
gs-3799	458	1	these	these	DET
gs-3799	458	2	configurations	configuration	NOUN
gs-3799	458	3	are	be	AUX
gs-3799	458	4	no	no	ADV
gs-3799	458	5	longer	long	ADV
gs-3799	458	6	confined	confine	VERB
gs-3799	458	7	to	to	ADP
gs-3799	458	8	the	the	DET
gs-3799	458	9	management	management	NOUN
gs-3799	458	10	of	of	ADP
gs-3799	458	11	flow	flow	NOUN
gs-3799	458	12	and	and	CCONJ
gs-3799	458	13	pressure	pressure	NOUN
gs-3799	458	14	but	but	CCONJ
gs-3799	458	15	are	be	AUX
gs-3799	458	16	evolving	evolve	VERB
gs-3799	458	17	into	into	ADP
gs-3799	458	18	multi	multi	ADJ
gs-3799	458	19	-	-	ADJ
gs-3799	458	20	input	input	ADJ
gs-3799	458	21	,	,	PUNCT
gs-3799	458	22	multi	multi	ADJ
gs-3799	458	23	-	-	ADJ
gs-3799	458	24	output	output	ADJ
gs-3799	458	25	(	(	PUNCT
gs-3799	458	26	mimo	mimo	PROPN
gs-3799	458	27	)	)	PUNCT
gs-3799	458	28	control	control	NOUN
gs-3799	458	29	systems	system	NOUN
gs-3799	458	30	.	.	PUNCT
gs-3799	459	1	such	such	ADJ
gs-3799	459	2	designs	design	NOUN
gs-3799	459	3	enable	enable	VERB
gs-3799	459	4	the	the	DET
gs-3799	459	5	simultaneous	simultaneous	ADJ
gs-3799	459	6	regulation	regulation	NOUN
gs-3799	459	7	of	of	ADP
gs-3799	459	8	diverse	diverse	ADJ
gs-3799	459	9	physiological	physiological	ADJ
gs-3799	459	10	targets	target	NOUN
gs-3799	459	11	,	,	PUNCT
gs-3799	459	12	including	include	VERB
gs-3799	459	13	systemic	systemic	ADJ
gs-3799	459	14	vascular	vascular	ADJ
gs-3799	459	15	resistance	resistance	NOUN
gs-3799	459	16	,	,	PUNCT
gs-3799	459	17	georgian	georgian	NOUN
gs-3799	459	18	scientists/	scientists/	NUM
gs-3799	459	19	.	.	PUNCT
gs-3799	460	1	7	7	NUM
gs-3799	460	2	n	n	DET
gs-3799	460	3	2	2	NUM
gs-3799	460	4	,	,	PUNCT
gs-3799	460	5	2025	2025	NUM
gs-3799	460	6	403	403	NUM
gs-3799	460	7	cerebral	cerebral	ADJ
gs-3799	460	8	oxygenation	oxygenation	NOUN
gs-3799	460	9	,	,	PUNCT
gs-3799	460	10	thermoregulation	thermoregulation	NOUN
gs-3799	460	11	,	,	PUNCT
gs-3799	460	12	glucose	glucose	NOUN
gs-3799	460	13	levels	level	NOUN
gs-3799	460	14	,	,	PUNCT
gs-3799	460	15	and	and	CCONJ
gs-3799	460	16	proinflammatory	proinflammatory	ADJ
gs-3799	460	17	cytokines	cytokine	NOUN
gs-3799	460	18	.	.	PUNCT
gs-3799	461	1	the	the	DET
gs-3799	461	2	orchestration	orchestration	NOUN
gs-3799	461	3	of	of	ADP
gs-3799	461	4	these	these	DET
gs-3799	461	5	subsystems	subsystem	NOUN
gs-3799	461	6	requires	require	VERB
gs-3799	461	7	an	an	DET
gs-3799	461	8	overarching	overarching	ADJ
gs-3799	461	9	supervisory	supervisory	ADJ
gs-3799	461	10	algorithm	algorithm	NOUN
gs-3799	461	11	capable	capable	ADJ
gs-3799	461	12	of	of	ADP
gs-3799	461	13	prioritizing	prioritize	VERB
gs-3799	461	14	and	and	CCONJ
gs-3799	461	15	reconciling	reconcile	VERB
gs-3799	461	16	conflicting	conflicting	ADJ
gs-3799	461	17	physiological	physiological	ADJ
gs-3799	461	18	objectives	objective	NOUN
gs-3799	461	19	—	—	PUNCT
gs-3799	461	20	such	such	ADJ
gs-3799	461	21	as	as	ADP
gs-3799	461	22	maximizing	maximize	VERB
gs-3799	461	23	renal	renal	ADJ
gs-3799	461	24	perfusion	perfusion	NOUN
gs-3799	461	25	without	without	ADP
gs-3799	461	26	compromising	compromise	VERB
gs-3799	461	27	cerebral	cerebral	ADJ
gs-3799	461	28	autoregulation	autoregulation	NOUN
gs-3799	461	29	.	.	PUNCT
gs-3799	462	1	preliminary	preliminary	ADJ
gs-3799	462	2	data	datum	NOUN
gs-3799	462	3	from	from	ADP
gs-3799	462	4	prototype	prototype	NOUN
gs-3799	462	5	systems	system	NOUN
gs-3799	462	6	employing	employ	VERB
gs-3799	462	7	hierarchical	hierarchical	ADJ
gs-3799	462	8	control	control	NOUN
gs-3799	462	9	models	model	NOUN
gs-3799	462	10	suggest	suggest	VERB
gs-3799	462	11	enhanced	enhance	VERB
gs-3799	462	12	stability	stability	NOUN
gs-3799	462	13	under	under	ADP
gs-3799	462	14	competing	compete	VERB
gs-3799	462	15	physiological	physiological	ADJ
gs-3799	462	16	demands	demand	NOUN
gs-3799	462	17	,	,	PUNCT
gs-3799	462	18	although	although	SCONJ
gs-3799	462	19	fine	fine	ADV
gs-3799	462	20	-	-	PUNCT
gs-3799	462	21	tuning	tune	VERB
gs-3799	462	22	the	the	DET
gs-3799	462	23	prioritization	prioritization	NOUN
gs-3799	462	24	matrix	matrix	NOUN
gs-3799	462	25	remains	remain	VERB
gs-3799	462	26	an	an	DET
gs-3799	462	27	ongoing	ongoing	ADJ
gs-3799	462	28	challenge	challenge	NOUN
gs-3799	462	29	.	.	PUNCT
gs-3799	463	1	an	an	DET
gs-3799	463	2	equally	equally	ADV
gs-3799	463	3	transformative	transformative	ADJ
gs-3799	463	4	development	development	NOUN
gs-3799	463	5	is	be	AUX
gs-3799	463	6	the	the	DET
gs-3799	463	7	incorporation	incorporation	NOUN
gs-3799	463	8	of	of	ADP
gs-3799	463	9	translational	translational	ADJ
gs-3799	463	10	bioinformatics	bioinformatic	NOUN
gs-3799	463	11	into	into	ADP
gs-3799	463	12	closed	closed	ADJ
gs-3799	463	13	-	-	PUNCT
gs-3799	463	14	loop	loop	NOUN
gs-3799	463	15	control	control	NOUN
gs-3799	463	16	.	.	PUNCT
gs-3799	464	1	by	by	ADP
gs-3799	464	2	integrating	integrate	VERB
gs-3799	464	3	patient	patient	NOUN
gs-3799	464	4	-	-	PUNCT
gs-3799	464	5	specific	specific	ADJ
gs-3799	464	6	genetic	genetic	ADJ
gs-3799	464	7	,	,	PUNCT
gs-3799	464	8	proteomic	proteomic	NOUN
gs-3799	464	9	,	,	PUNCT
gs-3799	464	10	and	and	CCONJ
gs-3799	464	11	metabolomic	metabolomic	ADJ
gs-3799	464	12	data	datum	NOUN
gs-3799	464	13	—	—	PUNCT
gs-3799	464	14	sourced	source	VERB
gs-3799	464	15	from	from	ADP
gs-3799	464	16	preoperative	preoperative	ADJ
gs-3799	464	17	assessments	assessment	NOUN
gs-3799	464	18	or	or	CCONJ
gs-3799	464	19	rapid	rapid	ADJ
gs-3799	464	20	intraoperative	intraoperative	ADJ
gs-3799	464	21	diagnostics	diagnostic	NOUN
gs-3799	464	22	—	—	PUNCT
gs-3799	464	23	algorithms	algorithm	NOUN
gs-3799	464	24	can	can	AUX
gs-3799	464	25	preemptively	preemptively	ADV
gs-3799	464	26	adjust	adjust	VERB
gs-3799	464	27	pharmacokinetic	pharmacokinetic	ADJ
gs-3799	464	28	assumptions	assumption	NOUN
gs-3799	464	29	,	,	PUNCT
gs-3799	464	30	organ	organ	NOUN
gs-3799	464	31	perfusion	perfusion	NOUN
gs-3799	464	32	baselines	baseline	NOUN
gs-3799	464	33	,	,	PUNCT
gs-3799	464	34	and	and	CCONJ
gs-3799	464	35	anticipated	anticipate	VERB
gs-3799	464	36	inflammatory	inflammatory	ADJ
gs-3799	464	37	thresholds	threshold	NOUN
gs-3799	464	38	.	.	PUNCT
gs-3799	465	1	this	this	DET
gs-3799	465	2	molecular	molecular	ADJ
gs-3799	465	3	personalization	personalization	NOUN
gs-3799	465	4	creates	create	VERB
gs-3799	465	5	an	an	DET
gs-3799	465	6	adaptive	adaptive	ADJ
gs-3799	465	7	framework	framework	NOUN
gs-3799	465	8	wherein	wherein	ADJ
gs-3799	465	9	standard	standard	ADJ
gs-3799	465	10	infusion	infusion	NOUN
gs-3799	465	11	regimens	regimen	NOUN
gs-3799	465	12	,	,	PUNCT
gs-3799	465	13	such	such	ADJ
gs-3799	465	14	as	as	ADP
gs-3799	465	15	heparin	heparin	ADJ
gs-3799	465	16	or	or	CCONJ
gs-3799	465	17	corticosteroids	corticosteroid	NOUN
gs-3799	465	18	,	,	PUNCT
gs-3799	465	19	are	be	AUX
gs-3799	465	20	dynamically	dynamically	ADV
gs-3799	465	21	recalibrated	recalibrate	VERB
gs-3799	465	22	in	in	ADP
gs-3799	465	23	response	response	NOUN
gs-3799	465	24	to	to	ADP
gs-3799	465	25	inferred	infer	VERB
gs-3799	465	26	drug	drug	NOUN
gs-3799	465	27	metabolism	metabolism	NOUN
gs-3799	465	28	profiles	profile	NOUN
gs-3799	465	29	or	or	CCONJ
gs-3799	465	30	inflammatory	inflammatory	ADJ
gs-3799	465	31	phenotypes	phenotype	NOUN
gs-3799	465	32	.	.	PUNCT
gs-3799	466	1	for	for	ADP
gs-3799	466	2	example	example	NOUN
gs-3799	466	3	,	,	PUNCT
gs-3799	466	4	real	real	ADJ
gs-3799	466	5	-	-	PUNCT
gs-3799	466	6	time	time	NOUN
gs-3799	466	7	updates	update	NOUN
gs-3799	466	8	to	to	ADP
gs-3799	466	9	hepatic	hepatic	ADJ
gs-3799	466	10	clearance	clearance	NOUN
gs-3799	466	11	rates	rate	NOUN
gs-3799	466	12	during	during	ADP
gs-3799	466	13	bypass	bypass	NOUN
gs-3799	466	14	,	,	PUNCT
gs-3799	466	15	extrapolated	extrapolate	VERB
gs-3799	466	16	from	from	ADP
gs-3799	466	17	dynamic	dynamic	ADJ
gs-3799	466	18	bilirubin	bilirubin	NOUN
gs-3799	466	19	and	and	CCONJ
gs-3799	466	20	enzyme	enzyme	NOUN
gs-3799	466	21	data	datum	NOUN
gs-3799	466	22	,	,	PUNCT
gs-3799	466	23	have	have	AUX
gs-3799	466	24	been	be	AUX
gs-3799	466	25	shown	show	VERB
gs-3799	466	26	to	to	PART
gs-3799	466	27	reduce	reduce	VERB
gs-3799	466	28	discrepancies	discrepancy	NOUN
gs-3799	466	29	between	between	ADP
gs-3799	466	30	predicted	predict	VERB
gs-3799	466	31	and	and	CCONJ
gs-3799	466	32	actual	actual	ADJ
gs-3799	466	33	drug	drug	NOUN
gs-3799	466	34	plasma	plasma	NOUN
gs-3799	466	35	concentrations	concentration	NOUN
gs-3799	466	36	,	,	PUNCT
gs-3799	466	37	leading	lead	VERB
gs-3799	466	38	to	to	ADP
gs-3799	466	39	safer	safe	ADJ
gs-3799	466	40	and	and	CCONJ
gs-3799	466	41	more	more	ADV
gs-3799	466	42	effective	effective	ADJ
gs-3799	466	43	intraoperative	intraoperative	ADJ
gs-3799	466	44	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	466	45	.	.	PUNCT
gs-3799	467	1	the	the	DET
gs-3799	467	2	role	role	NOUN
gs-3799	467	3	of	of	ADP
gs-3799	467	4	advanced	advanced	ADJ
gs-3799	467	5	pharmacodynamic	pharmacodynamic	ADJ
gs-3799	467	6	modeling	modeling	NOUN
gs-3799	467	7	in	in	ADP
gs-3799	467	8	closed	closed	ADJ
gs-3799	467	9	-	-	PUNCT
gs-3799	467	10	loop	loop	NOUN
gs-3799	467	11	therapy	therapy	NOUN
gs-3799	467	12	is	be	AUX
gs-3799	467	13	now	now	ADV
gs-3799	467	14	recognized	recognize	VERB
gs-3799	467	15	as	as	ADP
gs-3799	467	16	critical	critical	ADJ
gs-3799	467	17	to	to	ADP
gs-3799	467	18	optimal	optimal	ADJ
gs-3799	467	19	function	function	NOUN
gs-3799	467	20	.	.	PUNCT
gs-3799	468	1	classical	classical	ADJ
gs-3799	468	2	dosing	dosing	ADJ
gs-3799	468	3	paradigms	paradigm	NOUN
gs-3799	468	4	assume	assume	VERB
gs-3799	468	5	a	a	DET
gs-3799	468	6	relatively	relatively	ADV
gs-3799	468	7	static	static	ADJ
gs-3799	468	8	volume	volume	NOUN
gs-3799	468	9	of	of	ADP
gs-3799	468	10	distribution	distribution	NOUN
gs-3799	468	11	and	and	CCONJ
gs-3799	468	12	consistent	consistent	ADJ
gs-3799	468	13	receptor	receptor	NOUN
gs-3799	468	14	dynamics	dynamic	NOUN
gs-3799	468	15	,	,	PUNCT
gs-3799	468	16	neither	neither	PRON
gs-3799	468	17	of	of	ADP
gs-3799	468	18	which	which	PRON
gs-3799	468	19	holds	hold	VERB
gs-3799	468	20	true	true	ADJ
gs-3799	468	21	during	during	ADP
gs-3799	468	22	extracorporeal	extracorporeal	NOUN
gs-3799	468	23	circulation	circulation	NOUN
gs-3799	468	24	.	.	PUNCT
gs-3799	469	1	temperature	temperature	NOUN
gs-3799	469	2	variations	variation	NOUN
gs-3799	469	3	,	,	PUNCT
gs-3799	469	4	capillary	capillary	ADJ
gs-3799	469	5	leakage	leakage	NOUN
gs-3799	469	6	,	,	PUNCT
gs-3799	469	7	organ	organ	NOUN
gs-3799	469	8	ischemia	ischemia	NOUN
gs-3799	469	9	,	,	PUNCT
gs-3799	469	10	and	and	CCONJ
gs-3799	469	11	fluid	fluid	ADJ
gs-3799	469	12	shifts	shift	NOUN
gs-3799	469	13	all	all	PRON
gs-3799	469	14	substantially	substantially	ADV
gs-3799	469	15	alter	alter	VERB
gs-3799	469	16	drug	drug	NOUN
gs-3799	469	17	pharmacokinetics	pharmacokinetic	NOUN
gs-3799	469	18	.	.	PUNCT
gs-3799	470	1	closed	close	VERB
gs-3799	470	2	-	-	PUNCT
gs-3799	470	3	loop	loop	NOUN
gs-3799	470	4	systems	system	NOUN
gs-3799	470	5	that	that	PRON
gs-3799	470	6	utilize	utilize	VERB
gs-3799	470	7	bayesian	bayesian	NOUN
gs-3799	470	8	forecasting	forecasting	NOUN
gs-3799	470	9	algorithms	algorithm	NOUN
gs-3799	470	10	—	—	PUNCT
gs-3799	470	11	updated	update	VERB
gs-3799	470	12	in	in	ADP
gs-3799	470	13	real	real	ADJ
gs-3799	470	14	time	time	NOUN
gs-3799	470	15	with	with	ADP
gs-3799	470	16	biometric	biometric	ADJ
gs-3799	470	17	inputs	input	NOUN
gs-3799	470	18	such	such	ADJ
gs-3799	470	19	as	as	ADP
gs-3799	470	20	hepatic	hepatic	ADJ
gs-3799	470	21	perfusion	perfusion	NOUN
gs-3799	470	22	indices	index	NOUN
gs-3799	470	23	and	and	CCONJ
gs-3799	470	24	blood	blood	NOUN
gs-3799	470	25	-	-	PUNCT
gs-3799	470	26	brain	brain	NOUN
gs-3799	470	27	barrier	barrier	NOUN
gs-3799	470	28	permeability	permeability	NOUN
gs-3799	470	29	metrics	metric	NOUN
gs-3799	470	30	—	—	PUNCT
gs-3799	470	31	have	have	AUX
gs-3799	470	32	shown	show	VERB
gs-3799	470	33	statistically	statistically	ADV
gs-3799	470	34	significant	significant	ADJ
gs-3799	470	35	improvements	improvement	NOUN
gs-3799	470	36	in	in	ADP
gs-3799	470	37	maintaining	maintain	VERB
gs-3799	470	38	therapeutic	therapeutic	ADJ
gs-3799	470	39	windows	window	NOUN
gs-3799	470	40	for	for	ADP
gs-3799	470	41	labile	labile	ADJ
gs-3799	470	42	drugs	drug	NOUN
gs-3799	470	43	.	.	PUNCT
gs-3799	471	1	such	such	ADJ
gs-3799	471	2	advances	advance	NOUN
gs-3799	471	3	have	have	VERB
gs-3799	471	4	particular	particular	ADJ
gs-3799	471	5	relevance	relevance	NOUN
gs-3799	471	6	in	in	ADP
gs-3799	471	7	the	the	DET
gs-3799	471	8	dosing	dosing	NOUN
gs-3799	471	9	of	of	ADP
gs-3799	471	10	inotropes	inotrope	NOUN
gs-3799	471	11	,	,	PUNCT
gs-3799	471	12	anesthetics	anesthetic	NOUN
gs-3799	471	13	,	,	PUNCT
gs-3799	471	14	and	and	CCONJ
gs-3799	471	15	vasoactive	vasoactive	ADJ
gs-3799	471	16	agents	agent	NOUN
gs-3799	471	17	,	,	PUNCT
gs-3799	471	18	which	which	PRON
gs-3799	471	19	carry	carry	VERB
gs-3799	471	20	a	a	DET
gs-3799	471	21	narrow	narrow	ADJ
gs-3799	471	22	therapeutic	therapeutic	ADJ
gs-3799	471	23	index	index	NOUN
gs-3799	471	24	and	and	CCONJ
gs-3799	471	25	high	high	ADJ
gs-3799	471	26	variability	variability	NOUN
gs-3799	471	27	in	in	ADP
gs-3799	471	28	effect	effect	NOUN
gs-3799	471	29	.	.	PUNCT
gs-3799	472	1	the	the	DET
gs-3799	472	2	integration	integration	NOUN
gs-3799	472	3	of	of	ADP
gs-3799	472	4	closed	closed	ADJ
gs-3799	472	5	-	-	PUNCT
gs-3799	472	6	loop	loop	NOUN
gs-3799	472	7	systems	system	NOUN
gs-3799	472	8	into	into	ADP
gs-3799	472	9	global	global	ADJ
gs-3799	472	10	surgical	surgical	ADJ
gs-3799	472	11	ecosystems	ecosystem	NOUN
gs-3799	472	12	presents	present	VERB
gs-3799	472	13	another	another	DET
gs-3799	472	14	avenue	avenue	NOUN
gs-3799	472	15	of	of	ADP
gs-3799	472	16	investigation	investigation	NOUN
gs-3799	472	17	.	.	PUNCT
gs-3799	473	1	high	high	ADJ
gs-3799	473	2	-	-	PUNCT
gs-3799	473	3	income	income	NOUN
gs-3799	473	4	countries	country	NOUN
gs-3799	473	5	may	may	AUX
gs-3799	473	6	focus	focus	VERB
gs-3799	473	7	on	on	ADP
gs-3799	473	8	optimizing	optimize	VERB
gs-3799	473	9	surgical	surgical	ADJ
gs-3799	473	10	outcomes	outcome	NOUN
gs-3799	473	11	and	and	CCONJ
gs-3799	473	12	reducing	reduce	VERB
gs-3799	473	13	variability	variability	NOUN
gs-3799	473	14	,	,	PUNCT
gs-3799	473	15	but	but	CCONJ
gs-3799	473	16	in	in	ADP
gs-3799	473	17	resource	resource	NOUN
gs-3799	473	18	-	-	PUNCT
gs-3799	473	19	limited	limit	VERB
gs-3799	473	20	settings	setting	NOUN
gs-3799	473	21	,	,	PUNCT
gs-3799	473	22	the	the	DET
gs-3799	473	23	same	same	ADJ
gs-3799	473	24	technologies	technology	NOUN
gs-3799	473	25	offer	offer	VERB
gs-3799	473	26	the	the	DET
gs-3799	473	27	promise	promise	NOUN
gs-3799	473	28	of	of	ADP
gs-3799	473	29	workforce	workforce	NOUN
gs-3799	473	30	augmentation	augmentation	NOUN
gs-3799	473	31	and	and	CCONJ
gs-3799	473	32	improved	improve	VERB
gs-3799	473	33	procedural	procedural	ADJ
gs-3799	473	34	standardization	standardization	NOUN
gs-3799	473	35	.	.	PUNCT
gs-3799	474	1	pilot	pilot	NOUN
gs-3799	474	2	programs	program	NOUN
gs-3799	474	3	in	in	ADP
gs-3799	474	4	southeast	southeast	PROPN
gs-3799	474	5	asia	asia	PROPN
gs-3799	474	6	and	and	CCONJ
gs-3799	474	7	subsaharan	subsaharan	PROPN
gs-3799	474	8	africa	africa	PROPN
gs-3799	474	9	have	have	AUX
gs-3799	474	10	evaluated	evaluate	VERB
gs-3799	474	11	modular	modular	ADJ
gs-3799	474	12	,	,	PUNCT
gs-3799	474	13	portable	portable	ADJ
gs-3799	474	14	closed	closed	ADJ
gs-3799	474	15	-	-	PUNCT
gs-3799	474	16	loop	loop	NOUN
gs-3799	474	17	cpb	cpb	NOUN
gs-3799	474	18	units	unit	NOUN
gs-3799	474	19	designed	design	VERB
gs-3799	474	20	for	for	ADP
gs-3799	474	21	lower	low	ADJ
gs-3799	474	22	infrastructure	infrastructure	NOUN
gs-3799	474	23	requirements	requirement	NOUN
gs-3799	474	24	.	.	PUNCT
gs-3799	475	1	these	these	DET
gs-3799	475	2	systems	system	NOUN
gs-3799	475	3	,	,	PUNCT
gs-3799	475	4	powered	power	VERB
gs-3799	475	5	by	by	ADP
gs-3799	475	6	solar	solar	ADJ
gs-3799	475	7	-	-	PUNCT
gs-3799	475	8	capable	capable	ADJ
gs-3799	475	9	energy	energy	NOUN
gs-3799	475	10	modules	module	NOUN
gs-3799	475	11	and	and	CCONJ
gs-3799	475	12	relying	rely	VERB
gs-3799	475	13	on	on	ADP
gs-3799	475	14	locally	locally	ADV
gs-3799	475	15	fabricated	fabricate	VERB
gs-3799	475	16	tubing	tubing	NOUN
gs-3799	475	17	circuits	circuit	NOUN
gs-3799	475	18	,	,	PUNCT
gs-3799	475	19	have	have	AUX
gs-3799	475	20	successfully	successfully	ADV
gs-3799	475	21	replicated	replicate	VERB
gs-3799	475	22	core	core	NOUN
gs-3799	475	23	features	feature	NOUN
gs-3799	475	24	of	of	ADP
gs-3799	475	25	automated	automate	VERB
gs-3799	475	26	perfusion	perfusion	NOUN
gs-3799	475	27	and	and	CCONJ
gs-3799	475	28	pressure	pressure	NOUN
gs-3799	475	29	regulation	regulation	NOUN
gs-3799	475	30	.	.	PUNCT
gs-3799	476	1	outcome	outcome	NOUN
gs-3799	476	2	metrics	metric	NOUN
gs-3799	476	3	from	from	ADP
gs-3799	476	4	these	these	DET
gs-3799	476	5	pilot	pilot	NOUN
gs-3799	476	6	deployments	deployment	NOUN
gs-3799	476	7	indicate	indicate	VERB
gs-3799	476	8	not	not	PART
gs-3799	476	9	only	only	ADV
gs-3799	476	10	procedural	procedural	ADJ
gs-3799	476	11	safety	safety	NOUN
gs-3799	476	12	but	but	CCONJ
gs-3799	476	13	also	also	ADV
gs-3799	476	14	significantly	significantly	ADV
gs-3799	476	15	reduced	reduce	VERB
gs-3799	476	16	operator	operator	NOUN
gs-3799	476	17	dependency	dependency	NOUN
gs-3799	476	18	,	,	PUNCT
gs-3799	476	19	suggesting	suggest	VERB
gs-3799	476	20	that	that	SCONJ
gs-3799	476	21	closed	close	VERB
gs-3799	476	22	-	-	PUNCT
gs-3799	476	23	loop	loop	NOUN
gs-3799	476	24	systems	system	NOUN
gs-3799	476	25	may	may	AUX
gs-3799	476	26	democratize	democratize	VERB
gs-3799	476	27	access	access	NOUN
gs-3799	476	28	to	to	ADP
gs-3799	476	29	cardiac	cardiac	ADJ
gs-3799	476	30	surgery	surgery	NOUN
gs-3799	476	31	in	in	ADP
gs-3799	476	32	areas	area	NOUN
gs-3799	476	33	historically	historically	ADV
gs-3799	476	34	underserved	underserve	VERB
gs-3799	476	35	by	by	ADP
gs-3799	476	36	perfusionist	perfusionist	NOUN
gs-3799	476	37	expertise	expertise	NOUN
gs-3799	476	38	.	.	PUNCT
gs-3799	477	1	from	from	ADP
gs-3799	477	2	a	a	DET
gs-3799	477	3	comparative	comparative	ADJ
gs-3799	477	4	systems	system	NOUN
gs-3799	477	5	analysis	analysis	NOUN
gs-3799	477	6	perspective	perspective	NOUN
gs-3799	477	7	,	,	PUNCT
gs-3799	477	8	closed	closed	ADJ
gs-3799	477	9	-	-	PUNCT
gs-3799	477	10	loop	loop	NOUN
gs-3799	477	11	cpb	cpb	NOUN
gs-3799	477	12	designs	design	NOUN
gs-3799	477	13	are	be	AUX
gs-3799	477	14	increasingly	increasingly	ADV
gs-3799	477	15	contrasted	contrast	VERB
gs-3799	477	16	with	with	ADP
gs-3799	477	17	adjacent	adjacent	ADJ
gs-3799	477	18	technologies	technology	NOUN
gs-3799	477	19	in	in	ADP
gs-3799	477	20	anesthesia	anesthesia	PROPN
gs-3799	477	21	,	,	PUNCT
gs-3799	477	22	intensive	intensive	ADJ
gs-3799	477	23	care	care	NOUN
gs-3799	477	24	,	,	PUNCT
gs-3799	477	25	and	and	CCONJ
gs-3799	477	26	dialysis	dialysis	NOUN
gs-3799	477	27	.	.	PUNCT
gs-3799	478	1	unlike	unlike	ADP
gs-3799	478	2	anesthesia	anesthesia	NOUN
gs-3799	478	3	closed	close	VERB
gs-3799	478	4	-	-	PUNCT
gs-3799	478	5	loop	loop	NOUN
gs-3799	478	6	systems	system	NOUN
gs-3799	478	7	—	—	PUNCT
gs-3799	478	8	which	which	PRON
gs-3799	478	9	often	often	ADV
gs-3799	478	10	focus	focus	VERB
gs-3799	478	11	on	on	ADP
gs-3799	478	12	a	a	DET
gs-3799	478	13	single	single	ADJ
gs-3799	478	14	outcome	outcome	NOUN
gs-3799	478	15	such	such	ADJ
gs-3799	478	16	as	as	ADP
gs-3799	478	17	bispectral	bispectral	ADJ
gs-3799	478	18	index	index	NOUN
gs-3799	478	19	(	(	PUNCT
gs-3799	478	20	bis	bis	ADJ
gs-3799	478	21	)	)	PUNCT
gs-3799	478	22	stabilization	stabilization	NOUN
gs-3799	478	23	—	—	PUNCT
gs-3799	478	24	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	478	25	bypass	bypass	NOUN
gs-3799	478	26	requires	require	VERB
gs-3799	478	27	concurrent	concurrent	ADJ
gs-3799	478	28	management	management	NOUN
gs-3799	478	29	of	of	ADP
gs-3799	478	30	volumetric	volumetric	NOUN
gs-3799	478	31	,	,	PUNCT
gs-3799	478	32	biochemical	biochemical	ADJ
gs-3799	478	33	,	,	PUNCT
gs-3799	478	34	and	and	CCONJ
gs-3799	478	35	mechanical	mechanical	ADJ
gs-3799	478	36	variables	variable	NOUN
gs-3799	478	37	,	,	PUNCT
gs-3799	478	38	each	each	PRON
gs-3799	478	39	of	of	ADP
gs-3799	478	40	which	which	PRON
gs-3799	478	41	exhibits	exhibit	VERB
gs-3799	478	42	nonlinear	nonlinear	ADJ
gs-3799	478	43	and	and	CCONJ
gs-3799	478	44	often	often	ADV
gs-3799	478	45	chaotic	chaotic	ADJ
gs-3799	478	46	behavior	behavior	NOUN
gs-3799	478	47	.	.	PUNCT
gs-3799	479	1	dialysis	dialysis	NOUN
gs-3799	479	2	machines	machine	NOUN
gs-3799	479	3	,	,	PUNCT
gs-3799	479	4	by	by	ADP
gs-3799	479	5	contrast	contrast	NOUN
gs-3799	479	6	,	,	PUNCT
gs-3799	479	7	operate	operate	VERB
gs-3799	479	8	in	in	ADP
gs-3799	479	9	relatively	relatively	ADV
gs-3799	479	10	stable	stable	ADJ
gs-3799	479	11	extracorporeal	extracorporeal	NOUN
gs-3799	479	12	environments	environment	NOUN
gs-3799	479	13	.	.	PUNCT
gs-3799	480	1	as	as	ADP
gs-3799	480	2	such	such	ADJ
gs-3799	480	3	,	,	PUNCT
gs-3799	480	4	cpb	cpb	PROPN
gs-3799	480	5	closedgeorgian	closedgeorgian	NOUN
gs-3799	480	6	scientists/	scientists/	NUM
gs-3799	480	7	.	.	PUNCT
gs-3799	480	8	7	7	NUM
gs-3799	480	9	n	n	DET
gs-3799	480	10	2	2	NUM
gs-3799	480	11	,	,	PUNCT
gs-3799	480	12	2025	2025	NUM
gs-3799	480	13	404	404	NUM
gs-3799	480	14	loop	loop	NOUN
gs-3799	480	15	systems	system	NOUN
gs-3799	480	16	represent	represent	VERB
gs-3799	480	17	a	a	DET
gs-3799	480	18	unique	unique	ADJ
gs-3799	480	19	engineering	engineering	NOUN
gs-3799	480	20	and	and	CCONJ
gs-3799	480	21	physiologic	physiologic	ADJ
gs-3799	480	22	challenge	challenge	NOUN
gs-3799	480	23	,	,	PUNCT
gs-3799	480	24	situated	situate	VERB
gs-3799	480	25	at	at	ADP
gs-3799	480	26	the	the	DET
gs-3799	480	27	intersection	intersection	NOUN
gs-3799	480	28	of	of	ADP
gs-3799	480	29	transient	transient	ADJ
gs-3799	480	30	physiology	physiology	NOUN
gs-3799	480	31	and	and	CCONJ
gs-3799	480	32	real	real	ADJ
gs-3799	480	33	-	-	PUNCT
gs-3799	480	34	time	time	NOUN
gs-3799	480	35	mechanistic	mechanistic	ADJ
gs-3799	480	36	intervention	intervention	NOUN
gs-3799	480	37	.	.	PUNCT
gs-3799	481	1	this	this	DET
gs-3799	481	2	complexity	complexity	NOUN
gs-3799	481	3	mandates	mandate	VERB
gs-3799	481	4	novel	novel	ADJ
gs-3799	481	5	software	software	NOUN
gs-3799	481	6	architectures	architecture	NOUN
gs-3799	481	7	—	—	PUNCT
gs-3799	481	8	often	often	ADV
gs-3799	481	9	leveraging	leverage	VERB
gs-3799	481	10	real	real	ADJ
gs-3799	481	11	-	-	PUNCT
gs-3799	481	12	time	time	NOUN
gs-3799	481	13	operating	operating	NOUN
gs-3799	481	14	systems	system	NOUN
gs-3799	481	15	(	(	PUNCT
gs-3799	481	16	rtos	rtos	NOUN
gs-3799	481	17	)	)	PUNCT
gs-3799	481	18	and	and	CCONJ
gs-3799	481	19	distributed	distribute	VERB
gs-3799	481	20	processing	processing	NOUN
gs-3799	481	21	frameworks	framework	NOUN
gs-3799	481	22	—	—	PUNCT
gs-3799	481	23	to	to	PART
gs-3799	481	24	maintain	maintain	VERB
gs-3799	481	25	latency	latency	NOUN
gs-3799	481	26	below	below	ADP
gs-3799	481	27	clinically	clinically	ADV
gs-3799	481	28	significant	significant	ADJ
gs-3799	481	29	thresholds	threshold	NOUN
gs-3799	481	30	.	.	PUNCT
gs-3799	482	1	an	an	DET
gs-3799	482	2	important	important	ADJ
gs-3799	482	3	dimension	dimension	NOUN
gs-3799	482	4	to	to	PART
gs-3799	482	5	explore	explore	VERB
gs-3799	482	6	is	be	AUX
gs-3799	482	7	the	the	DET
gs-3799	482	8	cognitive	cognitive	ADJ
gs-3799	482	9	ergonomics	ergonomic	NOUN
gs-3799	482	10	and	and	CCONJ
gs-3799	482	11	sociotechnical	sociotechnical	ADJ
gs-3799	482	12	interaction	interaction	NOUN
gs-3799	482	13	within	within	ADP
gs-3799	482	14	the	the	DET
gs-3799	482	15	operative	operative	ADJ
gs-3799	482	16	environment	environment	NOUN
gs-3799	482	17	.	.	PUNCT
gs-3799	483	1	closed	close	VERB
gs-3799	483	2	-	-	PUNCT
gs-3799	483	3	loop	loop	NOUN
gs-3799	483	4	systems	system	NOUN
gs-3799	483	5	,	,	PUNCT
gs-3799	483	6	despite	despite	SCONJ
gs-3799	483	7	their	their	PRON
gs-3799	483	8	technical	technical	ADJ
gs-3799	483	9	autonomy	autonomy	NOUN
gs-3799	483	10	,	,	PUNCT
gs-3799	483	11	exist	exist	VERB
gs-3799	483	12	within	within	ADP
gs-3799	483	13	a	a	DET
gs-3799	483	14	human	human	ADJ
gs-3799	483	15	-	-	PUNCT
gs-3799	483	16	machine	machine	NOUN
gs-3799	483	17	interface	interface	NOUN
gs-3799	483	18	(	(	PUNCT
gs-3799	483	19	hmi	hmi	NOUN
gs-3799	483	20	)	)	PUNCT
gs-3799	483	21	ecosystem	ecosystem	NOUN
gs-3799	483	22	.	.	PUNCT
gs-3799	484	1	the	the	DET
gs-3799	484	2	introduction	introduction	NOUN
gs-3799	484	3	of	of	ADP
gs-3799	484	4	dynamic	dynamic	ADJ
gs-3799	484	5	interfaces	interface	NOUN
gs-3799	484	6	that	that	PRON
gs-3799	484	7	present	present	ADJ
gs-3799	484	8	data	datum	NOUN
gs-3799	484	9	not	not	PART
gs-3799	484	10	as	as	ADP
gs-3799	484	11	static	static	ADJ
gs-3799	484	12	readouts	readout	NOUN
gs-3799	484	13	but	but	CCONJ
gs-3799	484	14	as	as	ADP
gs-3799	484	15	evolving	evolve	VERB
gs-3799	484	16	risk	risk	NOUN
gs-3799	484	17	visualizations	visualization	NOUN
gs-3799	484	18	has	have	AUX
gs-3799	484	19	redefined	redefine	VERB
gs-3799	484	20	intraoperative	intraoperative	ADJ
gs-3799	484	21	situational	situational	ADJ
gs-3799	484	22	awareness	awareness	NOUN
gs-3799	484	23	.	.	PUNCT
gs-3799	485	1	clinical	clinical	ADJ
gs-3799	485	2	teams	team	NOUN
gs-3799	485	3	interacting	interact	VERB
gs-3799	485	4	with	with	ADP
gs-3799	485	5	predictive	predictive	ADJ
gs-3799	485	6	heatmaps	heatmap	NOUN
gs-3799	485	7	,	,	PUNCT
gs-3799	485	8	trajectory	trajectory	NOUN
gs-3799	485	9	visualizations	visualization	NOUN
gs-3799	485	10	of	of	ADP
gs-3799	485	11	map	map	NOUN
gs-3799	485	12	or	or	CCONJ
gs-3799	485	13	cerebral	cerebral	ADJ
gs-3799	485	14	saturation	saturation	NOUN
gs-3799	485	15	,	,	PUNCT
gs-3799	485	16	and	and	CCONJ
gs-3799	485	17	real	real	ADJ
gs-3799	485	18	-	-	PUNCT
gs-3799	485	19	time	time	NOUN
gs-3799	485	20	alert	alert	NOUN
gs-3799	485	21	modulation	modulation	NOUN
gs-3799	485	22	exhibit	exhibit	VERB
gs-3799	485	23	shorter	short	ADJ
gs-3799	485	24	response	response	NOUN
gs-3799	485	25	times	time	NOUN
gs-3799	485	26	and	and	CCONJ
gs-3799	485	27	greater	great	ADJ
gs-3799	485	28	procedural	procedural	ADJ
gs-3799	485	29	accuracy	accuracy	NOUN
gs-3799	485	30	.	.	PUNCT
gs-3799	486	1	controlled	control	VERB
gs-3799	486	2	trials	trial	NOUN
gs-3799	486	3	assessing	assess	VERB
gs-3799	486	4	operator	operator	NOUN
gs-3799	486	5	workload	workload	NOUN
gs-3799	486	6	demonstrate	demonstrate	VERB
gs-3799	486	7	a	a	DET
gs-3799	486	8	paradoxical	paradoxical	ADJ
gs-3799	486	9	reduction	reduction	NOUN
gs-3799	486	10	in	in	ADP
gs-3799	486	11	cognitive	cognitive	ADJ
gs-3799	486	12	fatigue	fatigue	NOUN
gs-3799	486	13	among	among	ADP
gs-3799	486	14	users	user	NOUN
gs-3799	486	15	of	of	ADP
gs-3799	486	16	high	high	ADJ
gs-3799	486	17	-	-	PUNCT
gs-3799	486	18	automation	automation	NOUN
gs-3799	486	19	systems	system	NOUN
gs-3799	486	20	,	,	PUNCT
gs-3799	486	21	despite	despite	SCONJ
gs-3799	486	22	a	a	DET
gs-3799	486	23	concomitant	concomitant	ADJ
gs-3799	486	24	increase	increase	NOUN
gs-3799	486	25	in	in	ADP
gs-3799	486	26	perceived	perceive	VERB
gs-3799	486	27	responsibility	responsibility	NOUN
gs-3799	486	28	.	.	PUNCT
gs-3799	487	1	this	this	PRON
gs-3799	487	2	indicates	indicate	VERB
gs-3799	487	3	a	a	DET
gs-3799	487	4	shift	shift	NOUN
gs-3799	487	5	from	from	ADP
gs-3799	487	6	task	task	NOUN
gs-3799	487	7	execution	execution	NOUN
gs-3799	487	8	to	to	ADP
gs-3799	487	9	supervisory	supervisory	ADJ
gs-3799	487	10	cognition	cognition	NOUN
gs-3799	487	11	—	—	PUNCT
gs-3799	487	12	essentially	essentially	ADV
gs-3799	487	13	reframing	reframe	VERB
gs-3799	487	14	the	the	DET
gs-3799	487	15	perfusionist	perfusionist	NOUN
gs-3799	487	16	’s	’s	PART
gs-3799	487	17	role	role	NOUN
gs-3799	487	18	as	as	ADP
gs-3799	487	19	a	a	DET
gs-3799	487	20	high	high	ADJ
gs-3799	487	21	-	-	PUNCT
gs-3799	487	22	level	level	NOUN
gs-3799	487	23	system	system	NOUN
gs-3799	487	24	integrator	integrator	NOUN
gs-3799	487	25	and	and	CCONJ
gs-3799	487	26	decision	decision	NOUN
gs-3799	487	27	facilitator	facilitator	NOUN
gs-3799	487	28	.	.	PUNCT
gs-3799	488	1	in	in	ADP
gs-3799	488	2	parallel	parallel	NOUN
gs-3799	488	3	,	,	PUNCT
gs-3799	488	4	the	the	DET
gs-3799	488	5	emergence	emergence	NOUN
gs-3799	488	6	of	of	ADP
gs-3799	488	7	real	real	ADJ
gs-3799	488	8	-	-	PUNCT
gs-3799	488	9	time	time	NOUN
gs-3799	488	10	physiologic	physiologic	ADJ
gs-3799	488	11	simulation	simulation	NOUN
gs-3799	488	12	engines	engine	NOUN
gs-3799	488	13	within	within	ADP
gs-3799	488	14	closed	closed	ADJ
gs-3799	488	15	-	-	PUNCT
gs-3799	488	16	loop	loop	NOUN
gs-3799	488	17	systems	system	NOUN
gs-3799	488	18	allows	allow	VERB
gs-3799	488	19	for	for	ADP
gs-3799	488	20	preprocedural	preprocedural	ADJ
gs-3799	488	21	rehearsals	rehearsal	NOUN
gs-3799	488	22	based	base	VERB
gs-3799	488	23	on	on	ADP
gs-3799	488	24	actual	actual	ADJ
gs-3799	488	25	patient	patient	ADJ
gs-3799	488	26	data	datum	NOUN
gs-3799	488	27	.	.	PUNCT
gs-3799	489	1	using	use	VERB
gs-3799	489	2	parameters	parameter	NOUN
gs-3799	489	3	extracted	extract	VERB
gs-3799	489	4	from	from	ADP
gs-3799	489	5	imaging	imaging	NOUN
gs-3799	489	6	,	,	PUNCT
gs-3799	489	7	laboratory	laboratory	NOUN
gs-3799	489	8	,	,	PUNCT
gs-3799	489	9	and	and	CCONJ
gs-3799	489	10	wearable	wearable	ADJ
gs-3799	489	11	sensors	sensor	NOUN
gs-3799	489	12	,	,	PUNCT
gs-3799	489	13	these	these	DET
gs-3799	489	14	systems	system	NOUN
gs-3799	489	15	can	can	AUX
gs-3799	489	16	simulate	simulate	VERB
gs-3799	489	17	patient	patient	NOUN
gs-3799	489	18	-	-	PUNCT
gs-3799	489	19	specific	specific	ADJ
gs-3799	489	20	responses	response	NOUN
gs-3799	489	21	to	to	ADP
gs-3799	489	22	bypass	bypass	NOUN
gs-3799	489	23	,	,	PUNCT
gs-3799	489	24	enabling	enable	VERB
gs-3799	489	25	both	both	CCONJ
gs-3799	489	26	algorithm	algorithm	NOUN
gs-3799	489	27	tuning	tuning	NOUN
gs-3799	489	28	and	and	CCONJ
gs-3799	489	29	surgical	surgical	ADJ
gs-3799	489	30	planning	planning	NOUN
gs-3799	489	31	.	.	PUNCT
gs-3799	490	1	when	when	SCONJ
gs-3799	490	2	coupled	couple	VERB
gs-3799	490	3	with	with	ADP
gs-3799	490	4	machine	machine	NOUN
gs-3799	490	5	learning	learning	NOUN
gs-3799	490	6	–	–	PUNCT
gs-3799	490	7	derived	derive	VERB
gs-3799	490	8	risk	risk	NOUN
gs-3799	490	9	stratification	stratification	NOUN
gs-3799	490	10	,	,	PUNCT
gs-3799	490	11	these	these	DET
gs-3799	490	12	simulations	simulation	NOUN
gs-3799	490	13	support	support	VERB
gs-3799	490	14	intraoperative	intraoperative	ADJ
gs-3799	490	15	decision	decision	NOUN
gs-3799	490	16	-	-	PUNCT
gs-3799	490	17	making	making	NOUN
gs-3799	490	18	regarding	regard	VERB
gs-3799	490	19	cannulation	cannulation	NOUN
gs-3799	490	20	strategy	strategy	NOUN
gs-3799	490	21	,	,	PUNCT
gs-3799	490	22	temperature	temperature	NOUN
gs-3799	490	23	management	management	NOUN
gs-3799	490	24	,	,	PUNCT
gs-3799	490	25	or	or	CCONJ
gs-3799	490	26	myocardial	myocardial	ADJ
gs-3799	490	27	protection	protection	NOUN
gs-3799	490	28	,	,	PUNCT
gs-3799	490	29	creating	create	VERB
gs-3799	490	30	a	a	DET
gs-3799	490	31	closedloop	closedloop	NOUN
gs-3799	490	32	feedback	feedback	NOUN
gs-3799	490	33	not	not	PART
gs-3799	490	34	only	only	ADV
gs-3799	490	35	in	in	ADP
gs-3799	490	36	control	control	NOUN
gs-3799	490	37	but	but	CCONJ
gs-3799	490	38	also	also	ADV
gs-3799	490	39	in	in	ADP
gs-3799	490	40	surgical	surgical	ADJ
gs-3799	490	41	intelligence	intelligence	NOUN
gs-3799	490	42	.	.	PUNCT
gs-3799	491	1	a	a	DET
gs-3799	491	2	persistent	persistent	ADJ
gs-3799	491	3	challenge	challenge	NOUN
gs-3799	491	4	remains	remain	VERB
gs-3799	491	5	the	the	DET
gs-3799	491	6	formal	formal	ADJ
gs-3799	491	7	validation	validation	NOUN
gs-3799	491	8	and	and	CCONJ
gs-3799	491	9	regulatory	regulatory	ADJ
gs-3799	491	10	approval	approval	NOUN
gs-3799	491	11	of	of	ADP
gs-3799	491	12	closed	closed	ADJ
gs-3799	491	13	-	-	PUNCT
gs-3799	491	14	loop	loop	NOUN
gs-3799	491	15	systems	system	NOUN
gs-3799	491	16	.	.	PUNCT
gs-3799	492	1	while	while	SCONJ
gs-3799	492	2	traditional	traditional	ADJ
gs-3799	492	3	devices	device	NOUN
gs-3799	492	4	are	be	AUX
gs-3799	492	5	evaluated	evaluate	VERB
gs-3799	492	6	based	base	VERB
gs-3799	492	7	on	on	ADP
gs-3799	492	8	discrete	discrete	ADJ
gs-3799	492	9	performance	performance	NOUN
gs-3799	492	10	endpoints	endpoint	NOUN
gs-3799	492	11	,	,	PUNCT
gs-3799	492	12	adaptive	adaptive	ADJ
gs-3799	492	13	systems	system	NOUN
gs-3799	492	14	necessitate	necessitate	ADJ
gs-3799	492	15	evaluation	evaluation	NOUN
gs-3799	492	16	across	across	ADP
gs-3799	492	17	a	a	DET
gs-3799	492	18	spectrum	spectrum	NOUN
gs-3799	492	19	of	of	ADP
gs-3799	492	20	dynamic	dynamic	ADJ
gs-3799	492	21	clinical	clinical	ADJ
gs-3799	492	22	scenarios	scenario	NOUN
gs-3799	492	23	.	.	PUNCT
gs-3799	493	1	to	to	PART
gs-3799	493	2	address	address	VERB
gs-3799	493	3	this	this	PRON
gs-3799	493	4	,	,	PUNCT
gs-3799	493	5	regulatory	regulatory	ADJ
gs-3799	493	6	bodies	body	NOUN
gs-3799	493	7	are	be	AUX
gs-3799	493	8	exploring	explore	VERB
gs-3799	493	9	model	model	NOUN
gs-3799	493	10	-	-	PUNCT
gs-3799	493	11	informed	inform	VERB
gs-3799	493	12	validation	validation	NOUN
gs-3799	493	13	frameworks	framework	NOUN
gs-3799	493	14	,	,	PUNCT
gs-3799	493	15	wherein	wherein	SCONJ
gs-3799	493	16	virtual	virtual	ADJ
gs-3799	493	17	patient	patient	NOUN
gs-3799	493	18	cohorts	cohort	NOUN
gs-3799	493	19	—	—	PUNCT
gs-3799	493	20	drawn	draw	VERB
gs-3799	493	21	from	from	ADP
gs-3799	493	22	real	real	ADJ
gs-3799	493	23	-	-	PUNCT
gs-3799	493	24	world	world	NOUN
gs-3799	493	25	physiological	physiological	ADJ
gs-3799	493	26	datasets	dataset	NOUN
gs-3799	493	27	—	—	PUNCT
gs-3799	493	28	are	be	AUX
gs-3799	493	29	subjected	subject	VERB
gs-3799	493	30	to	to	ADP
gs-3799	493	31	simulated	simulate	VERB
gs-3799	493	32	closed	close	VERB
gs-3799	493	33	-	-	PUNCT
gs-3799	493	34	loop	loop	NOUN
gs-3799	493	35	control	control	NOUN
gs-3799	493	36	to	to	PART
gs-3799	493	37	test	test	NOUN
gs-3799	493	38	failure	failure	NOUN
gs-3799	493	39	modes	mode	NOUN
gs-3799	493	40	,	,	PUNCT
gs-3799	493	41	rare	rare	ADJ
gs-3799	493	42	events	event	NOUN
gs-3799	493	43	,	,	PUNCT
gs-3799	493	44	and	and	CCONJ
gs-3799	493	45	edge	edge	NOUN
gs-3799	493	46	-	-	PUNCT
gs-3799	493	47	case	case	NOUN
gs-3799	493	48	scenarios	scenario	NOUN
gs-3799	493	49	.	.	PUNCT
gs-3799	494	1	this	this	DET
gs-3799	494	2	form	form	NOUN
gs-3799	494	3	of	of	ADP
gs-3799	494	4	in	in	ADP
gs-3799	494	5	silico	silico	NOUN
gs-3799	494	6	validation	validation	NOUN
gs-3799	494	7	,	,	PUNCT
gs-3799	494	8	if	if	SCONJ
gs-3799	494	9	standardized	standardize	VERB
gs-3799	494	10	,	,	PUNCT
gs-3799	494	11	could	could	AUX
gs-3799	494	12	dramatically	dramatically	ADV
gs-3799	494	13	accelerate	accelerate	VERB
gs-3799	494	14	the	the	DET
gs-3799	494	15	safe	safe	ADJ
gs-3799	494	16	deployment	deployment	NOUN
gs-3799	494	17	of	of	ADP
gs-3799	494	18	closed	closed	ADJ
gs-3799	494	19	-	-	PUNCT
gs-3799	494	20	loop	loop	NOUN
gs-3799	494	21	systems	system	NOUN
gs-3799	494	22	without	without	ADP
gs-3799	494	23	the	the	DET
gs-3799	494	24	ethical	ethical	ADJ
gs-3799	494	25	and	and	CCONJ
gs-3799	494	26	logistical	logistical	ADJ
gs-3799	494	27	burdens	burden	NOUN
gs-3799	494	28	of	of	ADP
gs-3799	494	29	prolonged	prolonged	ADJ
gs-3799	494	30	human	human	ADJ
gs-3799	494	31	trials	trial	NOUN
gs-3799	494	32	.	.	PUNCT
gs-3799	495	1	the	the	DET
gs-3799	495	2	economic	economic	ADJ
gs-3799	495	3	implications	implication	NOUN
gs-3799	495	4	of	of	ADP
gs-3799	495	5	closed	closed	ADJ
gs-3799	495	6	-	-	PUNCT
gs-3799	495	7	loop	loop	NOUN
gs-3799	495	8	adoption	adoption	NOUN
gs-3799	495	9	are	be	AUX
gs-3799	495	10	also	also	ADV
gs-3799	495	11	under	under	ADP
gs-3799	495	12	scrutiny	scrutiny	NOUN
gs-3799	495	13	.	.	PUNCT
gs-3799	496	1	early	early	ADJ
gs-3799	496	2	cost	cost	NOUN
gs-3799	496	3	-	-	PUNCT
gs-3799	496	4	benefit	benefit	NOUN
gs-3799	496	5	analyses	analysis	NOUN
gs-3799	496	6	,	,	PUNCT
gs-3799	496	7	conducted	conduct	VERB
gs-3799	496	8	primarily	primarily	ADV
gs-3799	496	9	in	in	ADP
gs-3799	496	10	tertiary	tertiary	ADJ
gs-3799	496	11	academic	academic	ADJ
gs-3799	496	12	centers	center	NOUN
gs-3799	496	13	,	,	PUNCT
gs-3799	496	14	indicate	indicate	VERB
gs-3799	496	15	favorable	favorable	ADJ
gs-3799	496	16	financial	financial	ADJ
gs-3799	496	17	outcomes	outcome	NOUN
gs-3799	496	18	when	when	SCONJ
gs-3799	496	19	measured	measure	VERB
gs-3799	496	20	against	against	ADP
gs-3799	496	21	reduced	reduce	VERB
gs-3799	496	22	icu	icu	PROPN
gs-3799	496	23	stays	stay	NOUN
gs-3799	496	24	,	,	PUNCT
gs-3799	496	25	lower	low	ADJ
gs-3799	496	26	transfusion	transfusion	NOUN
gs-3799	496	27	rates	rate	NOUN
gs-3799	496	28	,	,	PUNCT
gs-3799	496	29	and	and	CCONJ
gs-3799	496	30	fewer	few	ADJ
gs-3799	496	31	postoperative	postoperative	ADJ
gs-3799	496	32	complications	complication	NOUN
gs-3799	496	33	.	.	PUNCT
gs-3799	497	1	however	however	ADV
gs-3799	497	2	,	,	PUNCT
gs-3799	497	3	these	these	DET
gs-3799	497	4	analyses	analysis	NOUN
gs-3799	497	5	often	often	ADV
gs-3799	497	6	underestimate	underestimate	VERB
gs-3799	497	7	the	the	DET
gs-3799	497	8	upfront	upfront	ADJ
gs-3799	497	9	investment	investment	NOUN
gs-3799	497	10	required	require	VERB
gs-3799	497	11	for	for	ADP
gs-3799	497	12	system	system	NOUN
gs-3799	497	13	acquisition	acquisition	NOUN
gs-3799	497	14	,	,	PUNCT
gs-3799	497	15	training	training	NOUN
gs-3799	497	16	,	,	PUNCT
gs-3799	497	17	and	and	CCONJ
gs-3799	497	18	infrastructure	infrastructure	NOUN
gs-3799	497	19	integration	integration	NOUN
gs-3799	497	20	.	.	PUNCT
gs-3799	498	1	a	a	DET
gs-3799	498	2	more	more	ADV
gs-3799	498	3	holistic	holistic	ADJ
gs-3799	498	4	evaluation	evaluation	NOUN
gs-3799	498	5	of	of	ADP
gs-3799	498	6	return	return	NOUN
gs-3799	498	7	on	on	ADP
gs-3799	498	8	investment	investment	NOUN
gs-3799	498	9	—	—	PUNCT
gs-3799	498	10	one	one	NOUN
gs-3799	498	11	that	that	PRON
gs-3799	498	12	incorporates	incorporate	VERB
gs-3799	498	13	clinician	clinician	ADJ
gs-3799	498	14	time	time	NOUN
gs-3799	498	15	savings	saving	NOUN
gs-3799	498	16	,	,	PUNCT
gs-3799	498	17	downstream	downstream	ADJ
gs-3799	498	18	health	health	NOUN
gs-3799	498	19	benefits	benefit	NOUN
gs-3799	498	20	,	,	PUNCT
gs-3799	498	21	and	and	CCONJ
gs-3799	498	22	systemic	systemic	ADJ
gs-3799	498	23	efficiencies	efficiency	NOUN
gs-3799	498	24	—	—	PUNCT
gs-3799	498	25	is	be	AUX
gs-3799	498	26	required	require	VERB
gs-3799	498	27	to	to	PART
gs-3799	498	28	fully	fully	ADV
gs-3799	498	29	justify	justify	VERB
gs-3799	498	30	widespread	widespread	ADJ
gs-3799	498	31	implementation	implementation	NOUN
gs-3799	498	32	.	.	PUNCT
gs-3799	499	1	moreover	moreover	ADV
gs-3799	499	2	,	,	PUNCT
gs-3799	499	3	as	as	SCONJ
gs-3799	499	4	artificial	artificial	ADJ
gs-3799	499	5	intelligence	intelligence	NOUN
gs-3799	499	6	components	component	NOUN
gs-3799	499	7	become	become	VERB
gs-3799	499	8	more	more	ADV
gs-3799	499	9	central	central	ADJ
gs-3799	499	10	to	to	AUX
gs-3799	499	11	system	system	NOUN
gs-3799	499	12	function	function	NOUN
gs-3799	499	13	,	,	PUNCT
gs-3799	499	14	licensing	licensing	NOUN
gs-3799	499	15	models	model	NOUN
gs-3799	499	16	may	may	AUX
gs-3799	499	17	evolve	evolve	VERB
gs-3799	499	18	from	from	ADP
gs-3799	499	19	capital	capital	NOUN
gs-3799	499	20	expenditure	expenditure	NOUN
gs-3799	499	21	to	to	ADP
gs-3799	499	22	subscriptionbased	subscriptionbase	VERB
gs-3799	499	23	service	service	NOUN
gs-3799	499	24	architectures	architecture	NOUN
gs-3799	499	25	,	,	PUNCT
gs-3799	499	26	altering	alter	VERB
gs-3799	499	27	the	the	DET
gs-3799	499	28	fiscal	fiscal	ADJ
gs-3799	499	29	landscape	landscape	NOUN
gs-3799	499	30	of	of	ADP
gs-3799	499	31	surgical	surgical	ADJ
gs-3799	499	32	equipment	equipment	NOUN
gs-3799	499	33	acquisition	acquisition	NOUN
gs-3799	499	34	.	.	PUNCT
gs-3799	500	1	lastly	lastly	ADV
gs-3799	500	2	,	,	PUNCT
gs-3799	500	3	it	it	PRON
gs-3799	500	4	is	be	AUX
gs-3799	500	5	essential	essential	ADJ
gs-3799	500	6	to	to	PART
gs-3799	500	7	consider	consider	VERB
gs-3799	500	8	the	the	DET
gs-3799	500	9	longitudinal	longitudinal	ADJ
gs-3799	500	10	patient	patient	ADJ
gs-3799	500	11	trajectories	trajectory	NOUN
gs-3799	500	12	influenced	influence	VERB
gs-3799	500	13	by	by	ADP
gs-3799	500	14	closed	closed	ADJ
gs-3799	500	15	-	-	PUNCT
gs-3799	500	16	loop	loop	NOUN
gs-3799	500	17	cpb	cpb	NOUN
gs-3799	500	18	systems	system	NOUN
gs-3799	500	19	.	.	PUNCT
gs-3799	501	1	emerging	emerge	VERB
gs-3799	501	2	studies	study	NOUN
gs-3799	501	3	with	with	ADP
gs-3799	501	4	extended	extended	ADJ
gs-3799	501	5	postoperative	postoperative	ADJ
gs-3799	501	6	surveillance	surveillance	NOUN
gs-3799	501	7	reveal	reveal	VERB
gs-3799	501	8	that	that	SCONJ
gs-3799	501	9	patients	patient	NOUN
gs-3799	501	10	supported	support	VERB
gs-3799	501	11	by	by	ADP
gs-3799	501	12	automated	automate	VERB
gs-3799	501	13	systems	system	NOUN
gs-3799	501	14	exhibit	exhibit	VERB
gs-3799	501	15	not	not	PART
gs-3799	501	16	only	only	ADV
gs-3799	501	17	fewer	few	ADJ
gs-3799	501	18	immediate	immediate	ADJ
gs-3799	501	19	complications	complication	NOUN
gs-3799	501	20	but	but	CCONJ
gs-3799	501	21	also	also	ADV
gs-3799	501	22	improved	improve	VERB
gs-3799	501	23	midterm	midterm	NOUN
gs-3799	501	24	georgian	georgian	NOUN
gs-3799	501	25	scientists/	scientists/	NUM
gs-3799	501	26	.	.	PUNCT
gs-3799	502	1	7	7	NUM
gs-3799	502	2	n	n	PRON
gs-3799	502	3	2	2	NUM
gs-3799	502	4	,	,	PUNCT
gs-3799	502	5	2025	2025	NUM
gs-3799	502	6	405	405	NUM
gs-3799	502	7	metrics	metric	NOUN
gs-3799	502	8	such	such	ADJ
gs-3799	502	9	as	as	ADP
gs-3799	502	10	preserved	preserve	VERB
gs-3799	502	11	ejection	ejection	NOUN
gs-3799	502	12	fraction	fraction	NOUN
gs-3799	502	13	,	,	PUNCT
gs-3799	502	14	stable	stable	ADJ
gs-3799	502	15	renal	renal	ADJ
gs-3799	502	16	function	function	NOUN
gs-3799	502	17	,	,	PUNCT
gs-3799	502	18	and	and	CCONJ
gs-3799	502	19	reduced	reduce	VERB
gs-3799	502	20	inflammatory	inflammatory	ADJ
gs-3799	502	21	biomarkers	biomarker	NOUN
gs-3799	502	22	at	at	ADP
gs-3799	502	23	3–6	3–6	NUM
gs-3799	502	24	months	month	NOUN
gs-3799	502	25	.	.	PUNCT
gs-3799	503	1	whether	whether	SCONJ
gs-3799	503	2	these	these	DET
gs-3799	503	3	effects	effect	NOUN
gs-3799	503	4	persist	persist	VERB
gs-3799	503	5	beyond	beyond	ADP
gs-3799	503	6	a	a	DET
gs-3799	503	7	year	year	NOUN
gs-3799	503	8	,	,	PUNCT
gs-3799	503	9	or	or	CCONJ
gs-3799	503	10	translate	translate	VERB
gs-3799	503	11	into	into	ADP
gs-3799	503	12	improved	improved	ADJ
gs-3799	503	13	survival	survival	NOUN
gs-3799	503	14	and	and	CCONJ
gs-3799	503	15	quality	quality	NOUN
gs-3799	503	16	-	-	PUNCT
gs-3799	503	17	adjusted	adjust	VERB
gs-3799	503	18	life	life	NOUN
gs-3799	503	19	years	year	NOUN
gs-3799	503	20	(	(	PUNCT
gs-3799	503	21	qalys	qalys	PROPN
gs-3799	503	22	)	)	PUNCT
gs-3799	503	23	,	,	PUNCT
gs-3799	503	24	remains	remain	VERB
gs-3799	503	25	to	to	PART
gs-3799	503	26	be	be	AUX
gs-3799	503	27	seen	see	VERB
gs-3799	503	28	.	.	PUNCT
gs-3799	504	1	nonetheless	nonetheless	ADV
gs-3799	504	2	,	,	PUNCT
gs-3799	504	3	the	the	DET
gs-3799	504	4	trajectory	trajectory	NOUN
gs-3799	504	5	suggests	suggest	VERB
gs-3799	504	6	a	a	DET
gs-3799	504	7	shift	shift	NOUN
gs-3799	504	8	not	not	PART
gs-3799	504	9	merely	merely	ADV
gs-3799	504	10	in	in	ADP
gs-3799	504	11	procedural	procedural	ADJ
gs-3799	504	12	quality	quality	NOUN
gs-3799	504	13	but	but	CCONJ
gs-3799	504	14	in	in	ADP
gs-3799	504	15	the	the	DET
gs-3799	504	16	foundational	foundational	ADJ
gs-3799	504	17	physiology	physiology	NOUN
gs-3799	504	18	of	of	ADP
gs-3799	504	19	recovery	recovery	NOUN
gs-3799	504	20	itself	itself	PRON
gs-3799	504	21	—	—	PUNCT
gs-3799	504	22	a	a	DET
gs-3799	504	23	testament	testament	NOUN
gs-3799	504	24	to	to	ADP
gs-3799	504	25	the	the	DET
gs-3799	504	26	profound	profound	ADJ
gs-3799	504	27	influence	influence	NOUN
gs-3799	504	28	of	of	ADP
gs-3799	504	29	intraoperative	intraoperative	ADJ
gs-3799	504	30	precision	precision	NOUN
gs-3799	504	31	.	.	PUNCT
gs-3799	505	1	closed	close	VERB
gs-3799	505	2	-	-	PUNCT
gs-3799	505	3	loop	loop	NOUN
gs-3799	505	4	cpb	cpb	PROPN
gs-3799	505	5	systems	system	NOUN
gs-3799	505	6	are	be	AUX
gs-3799	505	7	no	no	ADV
gs-3799	505	8	longer	long	ADV
gs-3799	505	9	theoretical	theoretical	ADJ
gs-3799	505	10	constructs	construct	NOUN
gs-3799	505	11	but	but	CCONJ
gs-3799	505	12	are	be	AUX
gs-3799	505	13	advancing	advance	VERB
gs-3799	505	14	rapidly	rapidly	ADV
gs-3799	505	15	toward	toward	ADP
gs-3799	505	16	integrated	integrate	VERB
gs-3799	505	17	clinical	clinical	ADJ
gs-3799	505	18	reality	reality	NOUN
gs-3799	505	19	.	.	PUNCT
gs-3799	506	1	their	their	PRON
gs-3799	506	2	performance	performance	NOUN
gs-3799	506	3	,	,	PUNCT
gs-3799	506	4	adaptability	adaptability	NOUN
gs-3799	506	5	,	,	PUNCT
gs-3799	506	6	and	and	CCONJ
gs-3799	506	7	potential	potential	ADJ
gs-3799	506	8	to	to	PART
gs-3799	506	9	reshape	reshape	VERB
gs-3799	506	10	global	global	ADJ
gs-3799	506	11	cardiac	cardiac	ADJ
gs-3799	506	12	surgery	surgery	NOUN
gs-3799	506	13	practice	practice	NOUN
gs-3799	506	14	are	be	AUX
gs-3799	506	15	supported	support	VERB
gs-3799	506	16	by	by	ADP
gs-3799	506	17	a	a	DET
gs-3799	506	18	growing	grow	VERB
gs-3799	506	19	body	body	NOUN
gs-3799	506	20	of	of	ADP
gs-3799	506	21	data	datum	NOUN
gs-3799	506	22	and	and	CCONJ
gs-3799	506	23	technical	technical	ADJ
gs-3799	506	24	validation	validation	NOUN
gs-3799	506	25	.	.	PUNCT
gs-3799	507	1	as	as	ADP
gs-3799	507	2	this	this	DET
gs-3799	507	3	field	field	NOUN
gs-3799	507	4	matures	mature	NOUN
gs-3799	507	5	,	,	PUNCT
gs-3799	507	6	its	its	PRON
gs-3799	507	7	influence	influence	NOUN
gs-3799	507	8	will	will	AUX
gs-3799	507	9	extend	extend	VERB
gs-3799	507	10	beyond	beyond	ADP
gs-3799	507	11	extracorporeal	extracorporeal	NOUN
gs-3799	507	12	circuits	circuit	NOUN
gs-3799	507	13	into	into	ADP
gs-3799	507	14	the	the	DET
gs-3799	507	15	broader	broad	ADJ
gs-3799	507	16	domain	domain	NOUN
gs-3799	507	17	of	of	ADP
gs-3799	507	18	surgical	surgical	ADJ
gs-3799	507	19	automation	automation	NOUN
gs-3799	507	20	,	,	PUNCT
gs-3799	507	21	interventional	interventional	ADJ
gs-3799	507	22	intelligence	intelligence	NOUN
gs-3799	507	23	,	,	PUNCT
gs-3799	507	24	and	and	CCONJ
gs-3799	507	25	real	real	ADJ
gs-3799	507	26	-	-	PUNCT
gs-3799	507	27	time	time	NOUN
gs-3799	507	28	systems	system	NOUN
gs-3799	507	29	biology	biology	NOUN
gs-3799	507	30	—	—	PUNCT
gs-3799	507	31	ultimately	ultimately	ADV
gs-3799	507	32	redefining	redefine	VERB
gs-3799	507	33	not	not	PART
gs-3799	507	34	just	just	ADV
gs-3799	507	35	how	how	SCONJ
gs-3799	507	36	surgeries	surgery	NOUN
gs-3799	507	37	are	be	AUX
gs-3799	507	38	performed	perform	VERB
gs-3799	507	39	,	,	PUNCT
gs-3799	507	40	but	but	CCONJ
gs-3799	507	41	how	how	SCONJ
gs-3799	507	42	care	care	NOUN
gs-3799	507	43	itself	itself	PRON
gs-3799	507	44	is	be	AUX
gs-3799	507	45	conceptualized	conceptualize	VERB
gs-3799	507	46	,	,	PUNCT
gs-3799	507	47	delivered	deliver	VERB
gs-3799	507	48	,	,	PUNCT
gs-3799	507	49	and	and	CCONJ
gs-3799	507	50	experienced	experience	VERB
gs-3799	507	51	.	.	PUNCT
gs-3799	508	1	as	as	SCONJ
gs-3799	508	2	closed	closed	ADJ
gs-3799	508	3	-	-	PUNCT
gs-3799	508	4	loop	loop	NOUN
gs-3799	508	5	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	508	6	bypass	bypass	NOUN
gs-3799	508	7	(	(	PUNCT
gs-3799	508	8	cl	cl	NOUN
gs-3799	508	9	-	-	PUNCT
gs-3799	508	10	cpb	cpb	NOUN
gs-3799	508	11	)	)	PUNCT
gs-3799	508	12	systems	system	NOUN
gs-3799	508	13	reach	reach	VERB
gs-3799	508	14	higher	high	ADJ
gs-3799	508	15	levels	level	NOUN
gs-3799	508	16	of	of	ADP
gs-3799	508	17	sophistication	sophistication	NOUN
gs-3799	508	18	,	,	PUNCT
gs-3799	508	19	a	a	DET
gs-3799	508	20	fundamental	fundamental	ADJ
gs-3799	508	21	reframing	reframing	NOUN
gs-3799	508	22	of	of	ADP
gs-3799	508	23	system	system	NOUN
gs-3799	508	24	dynamics	dynamic	NOUN
gs-3799	508	25	is	be	AUX
gs-3799	508	26	emerging	emerge	VERB
gs-3799	508	27	—	—	PUNCT
gs-3799	508	28	one	one	NOUN
gs-3799	508	29	that	that	PRON
gs-3799	508	30	borrows	borrow	VERB
gs-3799	508	31	not	not	PART
gs-3799	508	32	merely	merely	ADV
gs-3799	508	33	from	from	ADP
gs-3799	508	34	engineering	engineering	NOUN
gs-3799	508	35	,	,	PUNCT
gs-3799	508	36	but	but	CCONJ
gs-3799	508	37	from	from	ADP
gs-3799	508	38	the	the	DET
gs-3799	508	39	principles	principle	NOUN
gs-3799	508	40	of	of	ADP
gs-3799	508	41	biological	biological	ADJ
gs-3799	508	42	cybernetics	cybernetic	NOUN
gs-3799	508	43	,	,	PUNCT
gs-3799	508	44	neuromodulation	neuromodulation	NOUN
gs-3799	508	45	,	,	PUNCT
gs-3799	508	46	and	and	CCONJ
gs-3799	508	47	emergent	emergent	ADJ
gs-3799	508	48	behavior	behavior	NOUN
gs-3799	508	49	theory	theory	NOUN
gs-3799	508	50	.	.	PUNCT
gs-3799	509	1	these	these	DET
gs-3799	509	2	systems	system	NOUN
gs-3799	509	3	now	now	ADV
gs-3799	509	4	function	function	VERB
gs-3799	509	5	not	not	PART
gs-3799	509	6	simply	simply	ADV
gs-3799	509	7	as	as	ADP
gs-3799	509	8	advanced	advanced	ADJ
gs-3799	509	9	regulators	regulator	NOUN
gs-3799	509	10	of	of	ADP
gs-3799	509	11	extracorporeal	extracorporeal	NOUN
gs-3799	509	12	flow	flow	NOUN
gs-3799	509	13	and	and	CCONJ
gs-3799	509	14	drug	drug	NOUN
gs-3799	509	15	delivery	delivery	NOUN
gs-3799	509	16	,	,	PUNCT
gs-3799	509	17	but	but	CCONJ
gs-3799	509	18	as	as	ADP
gs-3799	509	19	autonomously	autonomously	ADV
gs-3799	509	20	adaptive	adaptive	ADJ
gs-3799	509	21	entities	entity	NOUN
gs-3799	509	22	embedded	embed	VERB
gs-3799	509	23	in	in	ADP
gs-3799	509	24	an	an	DET
gs-3799	509	25	evolving	evolve	VERB
gs-3799	509	26	physiological	physiological	ADJ
gs-3799	509	27	matrix	matrix	NOUN
gs-3799	509	28	.	.	PUNCT
gs-3799	510	1	at	at	ADP
gs-3799	510	2	the	the	DET
gs-3799	510	3	core	core	NOUN
gs-3799	510	4	of	of	ADP
gs-3799	510	5	this	this	DET
gs-3799	510	6	transformation	transformation	NOUN
gs-3799	510	7	is	be	AUX
gs-3799	510	8	the	the	DET
gs-3799	510	9	use	use	NOUN
gs-3799	510	10	of	of	ADP
gs-3799	510	11	biocybernetic	biocybernetic	ADJ
gs-3799	510	12	control	control	NOUN
gs-3799	510	13	theory	theory	NOUN
gs-3799	510	14	,	,	PUNCT
gs-3799	510	15	in	in	ADP
gs-3799	510	16	which	which	PRON
gs-3799	510	17	the	the	DET
gs-3799	510	18	body	body	NOUN
gs-3799	510	19	is	be	AUX
gs-3799	510	20	modeled	model	VERB
gs-3799	510	21	not	not	PART
gs-3799	510	22	as	as	ADP
gs-3799	510	23	a	a	DET
gs-3799	510	24	passive	passive	ADJ
gs-3799	510	25	recipient	recipient	NOUN
gs-3799	510	26	of	of	ADP
gs-3799	510	27	perfusion	perfusion	NOUN
gs-3799	510	28	,	,	PUNCT
gs-3799	510	29	but	but	CCONJ
gs-3799	510	30	as	as	ADP
gs-3799	510	31	a	a	DET
gs-3799	510	32	dynamic	dynamic	ADJ
gs-3799	510	33	node	node	NOUN
gs-3799	510	34	in	in	ADP
gs-3799	510	35	a	a	DET
gs-3799	510	36	recursive	recursive	ADJ
gs-3799	510	37	feedback	feedback	NOUN
gs-3799	510	38	architecture	architecture	NOUN
gs-3799	510	39	.	.	PUNCT
gs-3799	511	1	within	within	ADP
gs-3799	511	2	this	this	DET
gs-3799	511	3	framework	framework	NOUN
gs-3799	511	4	,	,	PUNCT
gs-3799	511	5	physiological	physiological	ADJ
gs-3799	511	6	outputs	output	NOUN
gs-3799	511	7	such	such	ADJ
gs-3799	511	8	as	as	ADP
gs-3799	511	9	oxygen	oxygen	NOUN
gs-3799	511	10	delivery	delivery	NOUN
gs-3799	511	11	,	,	PUNCT
gs-3799	511	12	acid	acid	NOUN
gs-3799	511	13	-	-	PUNCT
gs-3799	511	14	base	base	NOUN
gs-3799	511	15	status	status	NOUN
gs-3799	511	16	,	,	PUNCT
gs-3799	511	17	and	and	CCONJ
gs-3799	511	18	hormonal	hormonal	ADJ
gs-3799	511	19	stress	stress	NOUN
gs-3799	511	20	signals	signal	NOUN
gs-3799	511	21	are	be	AUX
gs-3799	511	22	not	not	PART
gs-3799	511	23	endpoints	endpoint	NOUN
gs-3799	511	24	—	—	PUNCT
gs-3799	511	25	they	they	PRON
gs-3799	511	26	are	be	AUX
gs-3799	511	27	recursive	recursive	ADJ
gs-3799	511	28	signals	signal	NOUN
gs-3799	511	29	informing	inform	VERB
gs-3799	511	30	subsequent	subsequent	ADJ
gs-3799	511	31	system	system	NOUN
gs-3799	511	32	behaviors	behavior	NOUN
gs-3799	511	33	.	.	PUNCT
gs-3799	512	1	recent	recent	ADJ
gs-3799	512	2	implementations	implementation	NOUN
gs-3799	512	3	have	have	AUX
gs-3799	512	4	shifted	shift	VERB
gs-3799	512	5	from	from	ADP
gs-3799	512	6	static	static	ADJ
gs-3799	512	7	set	set	NOUN
gs-3799	512	8	-	-	PUNCT
gs-3799	512	9	point	point	NOUN
gs-3799	512	10	targeting	target	VERB
gs-3799	512	11	to	to	ADP
gs-3799	512	12	goal	goal	NOUN
gs-3799	512	13	-	-	PUNCT
gs-3799	512	14	directed	direct	VERB
gs-3799	512	15	adaptive	adaptive	ADJ
gs-3799	512	16	control	control	NOUN
gs-3799	512	17	loops	loop	NOUN
gs-3799	512	18	,	,	PUNCT
gs-3799	512	19	where	where	SCONJ
gs-3799	512	20	the	the	DET
gs-3799	512	21	desired	desire	VERB
gs-3799	512	22	physiological	physiological	ADJ
gs-3799	512	23	state	state	NOUN
gs-3799	512	24	is	be	AUX
gs-3799	512	25	continuously	continuously	ADV
gs-3799	512	26	recalculated	recalculate	VERB
gs-3799	512	27	based	base	VERB
gs-3799	512	28	on	on	ADP
gs-3799	512	29	system	system	NOUN
gs-3799	512	30	stability	stability	NOUN
gs-3799	512	31	,	,	PUNCT
gs-3799	512	32	patient	patient	NOUN
gs-3799	512	33	-	-	PUNCT
gs-3799	512	34	specific	specific	ADJ
gs-3799	512	35	variability	variability	NOUN
gs-3799	512	36	,	,	PUNCT
gs-3799	512	37	and	and	CCONJ
gs-3799	512	38	probabilistic	probabilistic	ADJ
gs-3799	512	39	modeling	modeling	NOUN
gs-3799	512	40	of	of	ADP
gs-3799	512	41	adverse	adverse	ADJ
gs-3799	512	42	trajectories	trajectory	NOUN
gs-3799	512	43	.	.	PUNCT
gs-3799	513	1	one	one	NUM
gs-3799	513	2	of	of	ADP
gs-3799	513	3	the	the	DET
gs-3799	513	4	most	most	ADV
gs-3799	513	5	significant	significant	ADJ
gs-3799	513	6	additions	addition	NOUN
gs-3799	513	7	to	to	ADP
gs-3799	513	8	the	the	DET
gs-3799	513	9	cl	cl	NOUN
gs-3799	513	10	-	-	PUNCT
gs-3799	513	11	cpb	cpb	NOUN
gs-3799	513	12	paradigm	paradigm	NOUN
gs-3799	513	13	is	be	AUX
gs-3799	513	14	the	the	DET
gs-3799	513	15	incorporation	incorporation	NOUN
gs-3799	513	16	of	of	ADP
gs-3799	513	17	neurophysiological	neurophysiological	ADJ
gs-3799	513	18	feedback	feedback	NOUN
gs-3799	513	19	,	,	PUNCT
gs-3799	513	20	particularly	particularly	ADV
gs-3799	513	21	cortical	cortical	ADJ
gs-3799	513	22	oxygenation	oxygenation	NOUN
gs-3799	513	23	and	and	CCONJ
gs-3799	513	24	evoked	evoke	VERB
gs-3799	513	25	potential	potential	ADJ
gs-3799	513	26	responsiveness	responsiveness	NOUN
gs-3799	513	27	.	.	PUNCT
gs-3799	514	1	this	this	DET
gs-3799	514	2	integration	integration	NOUN
gs-3799	514	3	recognizes	recognize	VERB
gs-3799	514	4	the	the	DET
gs-3799	514	5	primacy	primacy	NOUN
gs-3799	514	6	of	of	ADP
gs-3799	514	7	cerebral	cerebral	ADJ
gs-3799	514	8	protection	protection	NOUN
gs-3799	514	9	in	in	ADP
gs-3799	514	10	bypass	bypass	NOUN
gs-3799	514	11	outcomes	outcome	NOUN
gs-3799	514	12	.	.	PUNCT
gs-3799	515	1	systems	system	NOUN
gs-3799	515	2	now	now	ADV
gs-3799	515	3	under	under	ADP
gs-3799	515	4	investigation	investigation	NOUN
gs-3799	515	5	employ	employ	VERB
gs-3799	515	6	real	real	ADJ
gs-3799	515	7	-	-	PUNCT
gs-3799	515	8	time	time	NOUN
gs-3799	515	9	electroencephalography	electroencephalography	NOUN
gs-3799	515	10	(	(	PUNCT
gs-3799	515	11	eeg	eeg	NOUN
gs-3799	515	12	)	)	PUNCT
gs-3799	515	13	and	and	CCONJ
gs-3799	515	14	near	near	ADV
gs-3799	515	15	-	-	PUNCT
gs-3799	515	16	infrared	infrared	ADJ
gs-3799	515	17	spectroscopy	spectroscopy	NOUN
gs-3799	515	18	(	(	PUNCT
gs-3799	515	19	nirs	nir	NOUN
gs-3799	515	20	)	)	PUNCT
gs-3799	515	21	to	to	PART
gs-3799	515	22	modulate	modulate	VERB
gs-3799	515	23	perfusion	perfusion	NOUN
gs-3799	515	24	pressures	pressure	NOUN
gs-3799	515	25	,	,	PUNCT
gs-3799	515	26	temperature	temperature	NOUN
gs-3799	515	27	,	,	PUNCT
gs-3799	515	28	and	and	CCONJ
gs-3799	515	29	anesthetic	anesthetic	ADJ
gs-3799	515	30	delivery	delivery	NOUN
gs-3799	515	31	.	.	PUNCT
gs-3799	516	1	advanced	advanced	ADJ
gs-3799	516	2	signal	signal	NOUN
gs-3799	516	3	processing	processing	NOUN
gs-3799	516	4	techniques	technique	NOUN
gs-3799	516	5	,	,	PUNCT
gs-3799	516	6	including	include	VERB
gs-3799	516	7	wavelet	wavelet	NOUN
gs-3799	516	8	decomposition	decomposition	NOUN
gs-3799	516	9	and	and	CCONJ
gs-3799	516	10	coherence	coherence	NOUN
gs-3799	516	11	mapping	mapping	NOUN
gs-3799	516	12	,	,	PUNCT
gs-3799	516	13	are	be	AUX
gs-3799	516	14	used	use	VERB
gs-3799	516	15	to	to	PART
gs-3799	516	16	detect	detect	VERB
gs-3799	516	17	cortical	cortical	ADJ
gs-3799	516	18	desynchronization	desynchronization	NOUN
gs-3799	516	19	,	,	PUNCT
gs-3799	516	20	indicative	indicative	ADJ
gs-3799	516	21	of	of	ADP
gs-3799	516	22	early	early	ADJ
gs-3799	516	23	neuronal	neuronal	ADJ
gs-3799	516	24	stress	stress	NOUN
gs-3799	516	25	.	.	PUNCT
gs-3799	517	1	closed	close	VERB
gs-3799	517	2	-	-	PUNCT
gs-3799	517	3	loop	loop	NOUN
gs-3799	517	4	systems	system	NOUN
gs-3799	517	5	can	can	AUX
gs-3799	517	6	respond	respond	VERB
gs-3799	517	7	by	by	ADP
gs-3799	517	8	optimizing	optimize	VERB
gs-3799	517	9	flow	flow	NOUN
gs-3799	517	10	-	-	PUNCT
gs-3799	517	11	to	to	ADP
gs-3799	517	12	-	-	PUNCT
gs-3799	517	13	pressure	pressure	NOUN
gs-3799	517	14	ratios	ratio	NOUN
gs-3799	517	15	,	,	PUNCT
gs-3799	517	16	oxygen	oxygen	NOUN
gs-3799	517	17	delivery	delivery	NOUN
gs-3799	517	18	,	,	PUNCT
gs-3799	517	19	or	or	CCONJ
gs-3799	517	20	cerebral	cerebral	ADJ
gs-3799	517	21	autoregulation	autoregulation	NOUN
gs-3799	517	22	thresholds	threshold	NOUN
gs-3799	517	23	—	—	PUNCT
gs-3799	517	24	thus	thus	ADV
gs-3799	517	25	initiating	initiate	VERB
gs-3799	517	26	protective	protective	ADJ
gs-3799	517	27	neuroperfusion	neuroperfusion	NOUN
gs-3799	517	28	strategies	strategy	NOUN
gs-3799	517	29	.	.	PUNCT
gs-3799	518	1	equally	equally	ADV
gs-3799	518	2	important	important	ADJ
gs-3799	518	3	is	be	AUX
gs-3799	518	4	the	the	DET
gs-3799	518	5	study	study	NOUN
gs-3799	518	6	of	of	ADP
gs-3799	518	7	latency	latency	NOUN
gs-3799	518	8	theory	theory	NOUN
gs-3799	518	9	in	in	ADP
gs-3799	518	10	closed	closed	ADJ
gs-3799	518	11	-	-	PUNCT
gs-3799	518	12	loop	loop	NOUN
gs-3799	518	13	control	control	NOUN
gs-3799	518	14	,	,	PUNCT
gs-3799	518	15	particularly	particularly	ADV
gs-3799	518	16	in	in	ADP
gs-3799	518	17	high	high	ADJ
gs-3799	518	18	-	-	PUNCT
gs-3799	518	19	risk	risk	NOUN
gs-3799	518	20	cardiac	cardiac	ADJ
gs-3799	518	21	surgery	surgery	NOUN
gs-3799	518	22	.	.	PUNCT
gs-3799	519	1	latency	latency	NOUN
gs-3799	519	2	—	—	PUNCT
gs-3799	519	3	the	the	DET
gs-3799	519	4	delay	delay	NOUN
gs-3799	519	5	between	between	ADP
gs-3799	519	6	signal	signal	NOUN
gs-3799	519	7	acquisition	acquisition	NOUN
gs-3799	519	8	,	,	PUNCT
gs-3799	519	9	processing	processing	NOUN
gs-3799	519	10	,	,	PUNCT
gs-3799	519	11	and	and	CCONJ
gs-3799	519	12	action	action	NOUN
gs-3799	519	13	—	—	PUNCT
gs-3799	519	14	becomes	become	VERB
gs-3799	519	15	critical	critical	ADJ
gs-3799	519	16	when	when	SCONJ
gs-3799	519	17	dealing	deal	VERB
gs-3799	519	18	with	with	ADP
gs-3799	519	19	rapidly	rapidly	ADV
gs-3799	519	20	changing	change	VERB
gs-3799	519	21	hemodynamics	hemodynamic	NOUN
gs-3799	519	22	or	or	CCONJ
gs-3799	519	23	catastrophic	catastrophic	ADJ
gs-3799	519	24	feedback	feedback	NOUN
gs-3799	519	25	loops	loop	NOUN
gs-3799	519	26	,	,	PUNCT
gs-3799	519	27	such	such	ADJ
gs-3799	519	28	as	as	ADP
gs-3799	519	29	sudden	sudden	ADJ
gs-3799	519	30	systemic	systemic	ADJ
gs-3799	519	31	vascular	vascular	ADJ
gs-3799	519	32	resistance	resistance	NOUN
gs-3799	519	33	(	(	PUNCT
gs-3799	519	34	svr	svr	NOUN
gs-3799	519	35	)	)	PUNCT
gs-3799	519	36	collapse	collapse	NOUN
gs-3799	519	37	.	.	PUNCT
gs-3799	520	1	recent	recent	ADJ
gs-3799	520	2	benchmarking	benchmarke	VERB
gs-3799	520	3	studies	study	NOUN
gs-3799	520	4	have	have	AUX
gs-3799	520	5	shown	show	VERB
gs-3799	520	6	that	that	SCONJ
gs-3799	520	7	system	system	NOUN
gs-3799	520	8	efficacy	efficacy	NOUN
gs-3799	520	9	is	be	AUX
gs-3799	520	10	more	more	ADV
gs-3799	520	11	sensitive	sensitive	ADJ
gs-3799	520	12	to	to	ADP
gs-3799	520	13	processing	processing	NOUN
gs-3799	520	14	delays	delay	NOUN
gs-3799	520	15	than	than	ADP
gs-3799	520	16	to	to	ADP
gs-3799	520	17	the	the	DET
gs-3799	520	18	precision	precision	NOUN
gs-3799	520	19	of	of	ADP
gs-3799	520	20	the	the	DET
gs-3799	520	21	control	control	NOUN
gs-3799	520	22	algorithm	algorithm	NOUN
gs-3799	520	23	itself	itself	PRON
gs-3799	520	24	.	.	PUNCT
gs-3799	521	1	modern	modern	ADJ
gs-3799	521	2	cl	cl	NOUN
gs-3799	521	3	-	-	PUNCT
gs-3799	521	4	cpb	cpb	NOUN
gs-3799	521	5	systems	system	NOUN
gs-3799	521	6	are	be	AUX
gs-3799	521	7	thus	thus	ADV
gs-3799	521	8	being	be	AUX
gs-3799	521	9	re	re	VERB
gs-3799	521	10	-	-	VERB
gs-3799	521	11	engineered	engineer	VERB
gs-3799	521	12	with	with	ADP
gs-3799	521	13	edge	edge	NOUN
gs-3799	521	14	computing	computing	NOUN
gs-3799	521	15	nodes	node	NOUN
gs-3799	521	16	,	,	PUNCT
gs-3799	521	17	enabling	enable	VERB
gs-3799	521	18	near	near	ADP
gs-3799	521	19	-	-	PUNCT
gs-3799	521	20	zero	zero	NUM
gs-3799	521	21	millisecond	millisecond	NOUN
gs-3799	521	22	decision	decision	NOUN
gs-3799	521	23	latency	latency	NOUN
gs-3799	521	24	.	.	PUNCT
gs-3799	522	1	these	these	DET
gs-3799	522	2	distributed	distribute	VERB
gs-3799	522	3	architectures	architecture	NOUN
gs-3799	522	4	localize	localize	VERB
gs-3799	522	5	control	control	NOUN
gs-3799	522	6	logic	logic	NOUN
gs-3799	522	7	near	near	ADP
gs-3799	522	8	critical	critical	ADJ
gs-3799	522	9	sensors	sensor	NOUN
gs-3799	522	10	(	(	PUNCT
gs-3799	522	11	e.g.	e.g.	ADV
gs-3799	522	12	,	,	PUNCT
gs-3799	522	13	aortic	aortic	ADJ
gs-3799	522	14	root	root	NOUN
gs-3799	522	15	flowmeters	flowmeter	NOUN
gs-3799	522	16	,	,	PUNCT
gs-3799	522	17	cerebral	cerebral	ADJ
gs-3799	522	18	oximetry	oximetry	NOUN
gs-3799	522	19	probes	probe	NOUN
gs-3799	522	20	)	)	PUNCT
gs-3799	522	21	,	,	PUNCT
gs-3799	522	22	reducing	reduce	VERB
gs-3799	522	23	transmission	transmission	NOUN
gs-3799	522	24	georgian	georgian	NOUN
gs-3799	522	25	scientists/	scientists/	NUM
gs-3799	522	26	.	.	PUNCT
gs-3799	523	1	7	7	NUM
gs-3799	523	2	n	n	PRON
gs-3799	523	3	2	2	NUM
gs-3799	523	4	,	,	PUNCT
gs-3799	523	5	2025	2025	NUM
gs-3799	523	6	406	406	NUM
gs-3799	523	7	bottlenecks	bottleneck	NOUN
gs-3799	523	8	and	and	CCONJ
gs-3799	523	9	improving	improve	VERB
gs-3799	523	10	system	system	NOUN
gs-3799	523	11	responsiveness	responsiveness	NOUN
gs-3799	523	12	during	during	ADP
gs-3799	523	13	dynamic	dynamic	ADJ
gs-3799	523	14	transitions	transition	NOUN
gs-3799	523	15	such	such	ADJ
gs-3799	523	16	as	as	ADP
gs-3799	523	17	cross	cross	NOUN
gs-3799	523	18	-	-	ADJ
gs-3799	523	19	clamping	clamp	VERB
gs-3799	523	20	or	or	CCONJ
gs-3799	523	21	rewarming	rewarming	NOUN
gs-3799	523	22	.	.	PUNCT
gs-3799	524	1	another	another	DET
gs-3799	524	2	high	high	ADJ
gs-3799	524	3	-	-	PUNCT
gs-3799	524	4	priority	priority	NOUN
gs-3799	524	5	domain	domain	NOUN
gs-3799	524	6	of	of	ADP
gs-3799	524	7	analysis	analysis	NOUN
gs-3799	524	8	involves	involve	VERB
gs-3799	524	9	failure	failure	NOUN
gs-3799	524	10	mode	mode	NOUN
gs-3799	524	11	and	and	CCONJ
gs-3799	524	12	effect	effect	VERB
gs-3799	524	13	analysis	analysis	NOUN
gs-3799	524	14	(	(	PUNCT
gs-3799	524	15	fmea	fmea	NOUN
gs-3799	524	16	)	)	PUNCT
gs-3799	524	17	under	under	ADP
gs-3799	524	18	real	real	ADJ
gs-3799	524	19	-	-	PUNCT
gs-3799	524	20	time	time	NOUN
gs-3799	524	21	conditions	condition	NOUN
gs-3799	524	22	.	.	PUNCT
gs-3799	525	1	while	while	SCONJ
gs-3799	525	2	static	static	ADJ
gs-3799	525	3	safety	safety	NOUN
gs-3799	525	4	testing	testing	NOUN
gs-3799	525	5	evaluates	evaluate	NOUN
gs-3799	525	6	discrete	discrete	ADJ
gs-3799	525	7	control	control	NOUN
gs-3799	525	8	scenarios	scenario	NOUN
gs-3799	525	9	,	,	PUNCT
gs-3799	525	10	real	real	ADJ
gs-3799	525	11	-	-	PUNCT
gs-3799	525	12	time	time	NOUN
gs-3799	525	13	fmea	fmea	NOUN
gs-3799	525	14	evaluates	evaluate	VERB
gs-3799	525	15	the	the	DET
gs-3799	525	16	compound	compound	NOUN
gs-3799	525	17	and	and	CCONJ
gs-3799	525	18	emergent	emergent	ADJ
gs-3799	525	19	failures	failure	NOUN
gs-3799	525	20	of	of	ADP
gs-3799	525	21	multi	multi	ADJ
gs-3799	525	22	-	-	ADJ
gs-3799	525	23	variable	variable	ADJ
gs-3799	525	24	closed	closed	ADJ
gs-3799	525	25	-	-	PUNCT
gs-3799	525	26	loop	loop	NOUN
gs-3799	525	27	logic	logic	NOUN
gs-3799	525	28	under	under	ADP
gs-3799	525	29	duress	duress	NOUN
gs-3799	525	30	.	.	PUNCT
gs-3799	526	1	examples	example	NOUN
gs-3799	526	2	include	include	VERB
gs-3799	526	3	sensor	sensor	NOUN
gs-3799	526	4	disconnection	disconnection	NOUN
gs-3799	526	5	mid	mid	NOUN
gs-3799	526	6	-	-	NOUN
gs-3799	526	7	procedure	procedure	NOUN
gs-3799	526	8	,	,	PUNCT
gs-3799	526	9	paradoxical	paradoxical	ADJ
gs-3799	526	10	feedback	feedback	NOUN
gs-3799	526	11	loops	loop	NOUN
gs-3799	526	12	where	where	SCONJ
gs-3799	526	13	algorithmic	algorithmic	ADJ
gs-3799	526	14	response	response	NOUN
gs-3799	526	15	exacerbates	exacerbate	VERB
gs-3799	526	16	instability	instability	NOUN
gs-3799	526	17	(	(	PUNCT
gs-3799	526	18	e.g.	e.g.	ADV
gs-3799	526	19	,	,	PUNCT
gs-3799	526	20	vasopressor	vasopressor	NOUN
gs-3799	526	21	-	-	PUNCT
gs-3799	526	22	induced	induce	VERB
gs-3799	526	23	afterload	afterload	NOUN
gs-3799	526	24	spikes	spike	NOUN
gs-3799	526	25	)	)	PUNCT
gs-3799	526	26	,	,	PUNCT
gs-3799	526	27	and	and	CCONJ
gs-3799	526	28	systemic	systemic	ADJ
gs-3799	526	29	desensitization	desensitization	NOUN
gs-3799	526	30	to	to	PART
gs-3799	526	31	noise	noise	VERB
gs-3799	526	32	filtering	filter	VERB
gs-3799	526	33	.	.	PUNCT
gs-3799	527	1	advanced	advanced	ADJ
gs-3799	527	2	cl	cl	NOUN
gs-3799	527	3	-	-	PUNCT
gs-3799	527	4	cpb	cpb	NOUN
gs-3799	527	5	systems	system	NOUN
gs-3799	527	6	now	now	ADV
gs-3799	527	7	embed	embed	VERB
gs-3799	527	8	self	self	NOUN
gs-3799	527	9	-	-	PUNCT
gs-3799	527	10	diagnostic	diagnostic	ADJ
gs-3799	527	11	subroutines	subroutine	NOUN
gs-3799	527	12	that	that	PRON
gs-3799	527	13	initiate	initiate	VERB
gs-3799	527	14	fallback	fallback	NOUN
gs-3799	527	15	modes	mode	NOUN
gs-3799	527	16	upon	upon	SCONJ
gs-3799	527	17	detecting	detect	VERB
gs-3799	527	18	control	control	NOUN
gs-3799	527	19	instability	instability	NOUN
gs-3799	527	20	,	,	PUNCT
gs-3799	527	21	such	such	ADJ
gs-3799	527	22	as	as	ADP
gs-3799	527	23	reverting	revert	VERB
gs-3799	527	24	to	to	ADP
gs-3799	527	25	open	open	ADJ
gs-3799	527	26	-	-	PUNCT
gs-3799	527	27	loop	loop	NOUN
gs-3799	527	28	alerts	alert	NOUN
gs-3799	527	29	or	or	CCONJ
gs-3799	527	30	human	human	ADJ
gs-3799	527	31	handover	handover	NOUN
gs-3799	527	32	in	in	ADP
gs-3799	527	33	the	the	DET
gs-3799	527	34	event	event	NOUN
gs-3799	527	35	of	of	ADP
gs-3799	527	36	high	high	ADJ
gs-3799	527	37	entropy	entropy	NOUN
gs-3799	527	38	states	state	NOUN
gs-3799	527	39	.	.	PUNCT
gs-3799	528	1	the	the	DET
gs-3799	528	2	formal	formal	ADJ
gs-3799	528	3	modeling	modeling	NOUN
gs-3799	528	4	of	of	ADP
gs-3799	528	5	“	"	PUNCT
gs-3799	528	6	graceful	graceful	ADJ
gs-3799	528	7	degradation	degradation	NOUN
gs-3799	528	8	”	"	PUNCT
gs-3799	528	9	—	—	PUNCT
gs-3799	528	10	where	where	SCONJ
gs-3799	528	11	the	the	DET
gs-3799	528	12	system	system	NOUN
gs-3799	528	13	continues	continue	VERB
gs-3799	528	14	to	to	PART
gs-3799	528	15	operate	operate	VERB
gs-3799	528	16	under	under	ADP
gs-3799	528	17	partial	partial	ADJ
gs-3799	528	18	functionality	functionality	NOUN
gs-3799	528	19	without	without	ADP
gs-3799	528	20	catastrophic	catastrophic	ADJ
gs-3799	528	21	failure	failure	NOUN
gs-3799	528	22	—	—	PUNCT
gs-3799	528	23	is	be	AUX
gs-3799	528	24	now	now	ADV
gs-3799	528	25	a	a	DET
gs-3799	528	26	requirement	requirement	NOUN
gs-3799	528	27	in	in	ADP
gs-3799	528	28	the	the	DET
gs-3799	528	29	next	next	ADJ
gs-3799	528	30	wave	wave	NOUN
gs-3799	528	31	of	of	ADP
gs-3799	528	32	regulatory	regulatory	ADJ
gs-3799	528	33	standards	standard	NOUN
gs-3799	528	34	for	for	ADP
gs-3799	528	35	autonomous	autonomous	ADJ
gs-3799	528	36	perfusion	perfusion	NOUN
gs-3799	528	37	systems	system	NOUN
gs-3799	528	38	.	.	PUNCT
gs-3799	529	1	translational	translational	ADJ
gs-3799	529	2	immunoinformatics	immunoinformatic	NOUN
gs-3799	529	3	is	be	AUX
gs-3799	529	4	increasingly	increasingly	ADV
gs-3799	529	5	recognized	recognize	VERB
gs-3799	529	6	as	as	ADP
gs-3799	529	7	a	a	DET
gs-3799	529	8	bridge	bridge	NOUN
gs-3799	529	9	between	between	ADP
gs-3799	529	10	bypassinduced	bypassinduce	VERB
gs-3799	529	11	systemic	systemic	ADJ
gs-3799	529	12	inflammation	inflammation	NOUN
gs-3799	529	13	and	and	CCONJ
gs-3799	529	14	real	real	ADJ
gs-3799	529	15	-	-	PUNCT
gs-3799	529	16	time	time	NOUN
gs-3799	529	17	immunomodulatory	immunomodulatory	ADJ
gs-3799	529	18	control	control	NOUN
gs-3799	529	19	.	.	PUNCT
gs-3799	530	1	cpb	cpb	NOUN
gs-3799	530	2	-	-	PUNCT
gs-3799	530	3	induced	induce	VERB
gs-3799	530	4	systemic	systemic	ADJ
gs-3799	530	5	inflammatory	inflammatory	ADJ
gs-3799	530	6	response	response	NOUN
gs-3799	530	7	syndrome	syndrome	NOUN
gs-3799	530	8	(	(	PUNCT
gs-3799	530	9	sirs	sirs	PROPN
gs-3799	530	10	)	)	PUNCT
gs-3799	530	11	is	be	AUX
gs-3799	530	12	a	a	DET
gs-3799	530	13	major	major	ADJ
gs-3799	530	14	driver	driver	NOUN
gs-3799	530	15	of	of	ADP
gs-3799	530	16	morbidity	morbidity	NOUN
gs-3799	530	17	,	,	PUNCT
gs-3799	530	18	yet	yet	CCONJ
gs-3799	530	19	its	its	PRON
gs-3799	530	20	temporal	temporal	ADJ
gs-3799	530	21	onset	onset	NOUN
gs-3799	530	22	and	and	CCONJ
gs-3799	530	23	intensity	intensity	NOUN
gs-3799	530	24	are	be	AUX
gs-3799	530	25	poorly	poorly	ADV
gs-3799	530	26	predicted	predict	VERB
gs-3799	530	27	.	.	PUNCT
gs-3799	531	1	closed	close	VERB
gs-3799	531	2	-	-	PUNCT
gs-3799	531	3	loop	loop	NOUN
gs-3799	531	4	systems	system	NOUN
gs-3799	531	5	are	be	AUX
gs-3799	531	6	now	now	ADV
gs-3799	531	7	being	be	AUX
gs-3799	531	8	designed	design	VERB
gs-3799	531	9	with	with	ADP
gs-3799	531	10	integrated	integrate	VERB
gs-3799	531	11	cytokine	cytokine	NOUN
gs-3799	531	12	monitoring	monitoring	NOUN
gs-3799	531	13	(	(	PUNCT
gs-3799	531	14	e.g.	e.g.	ADV
gs-3799	531	15	,	,	PUNCT
gs-3799	531	16	il-6	il-6	NUM
gs-3799	531	17	,	,	PUNCT
gs-3799	531	18	tnf	tnf	PROPN
gs-3799	531	19	-	-	PUNCT
gs-3799	531	20	alpha	alpha	NOUN
gs-3799	531	21	)	)	PUNCT
gs-3799	531	22	,	,	PUNCT
gs-3799	531	23	not	not	PART
gs-3799	531	24	simply	simply	ADV
gs-3799	531	25	as	as	ADP
gs-3799	531	26	post	post	ADJ
gs-3799	531	27	-	-	ADJ
gs-3799	531	28	hoc	hoc	ADJ
gs-3799	531	29	data	datum	NOUN
gs-3799	531	30	points	point	NOUN
gs-3799	531	31	but	but	CCONJ
gs-3799	531	32	as	as	ADP
gs-3799	531	33	algorithmic	algorithmic	ADJ
gs-3799	531	34	control	control	NOUN
gs-3799	531	35	signals	signal	NOUN
gs-3799	531	36	.	.	PUNCT
gs-3799	532	1	the	the	DET
gs-3799	532	2	ability	ability	NOUN
gs-3799	532	3	to	to	PART
gs-3799	532	4	modulate	modulate	VERB
gs-3799	532	5	ultrafiltration	ultrafiltration	NOUN
gs-3799	532	6	,	,	PUNCT
gs-3799	532	7	corticosteroid	corticosteroid	ADJ
gs-3799	532	8	infusion	infusion	NOUN
gs-3799	532	9	,	,	PUNCT
gs-3799	532	10	and	and	CCONJ
gs-3799	532	11	endotoxin	endotoxin	ADJ
gs-3799	532	12	absorption	absorption	NOUN
gs-3799	532	13	in	in	ADP
gs-3799	532	14	real	real	ADJ
gs-3799	532	15	-	-	PUNCT
gs-3799	532	16	time	time	NOUN
gs-3799	532	17	—	—	PUNCT
gs-3799	532	18	based	base	VERB
gs-3799	532	19	on	on	ADP
gs-3799	532	20	immune	immune	ADJ
gs-3799	532	21	flux	flux	NOUN
gs-3799	532	22	rather	rather	ADV
gs-3799	532	23	than	than	ADP
gs-3799	532	24	static	static	ADJ
gs-3799	532	25	dosing	dosing	NOUN
gs-3799	532	26	—	—	PUNCT
gs-3799	532	27	has	have	AUX
gs-3799	532	28	demonstrated	demonstrate	VERB
gs-3799	532	29	early	early	ADJ
gs-3799	532	30	promise	promise	NOUN
gs-3799	532	31	in	in	ADP
gs-3799	532	32	porcine	porcine	NOUN
gs-3799	532	33	and	and	CCONJ
gs-3799	532	34	canine	canine	NOUN
gs-3799	532	35	models	model	NOUN
gs-3799	532	36	.	.	PUNCT
gs-3799	533	1	by	by	ADP
gs-3799	533	2	dynamically	dynamically	ADV
gs-3799	533	3	attenuating	attenuate	VERB
gs-3799	533	4	the	the	DET
gs-3799	533	5	inflammatory	inflammatory	ADJ
gs-3799	533	6	cascade	cascade	NOUN
gs-3799	533	7	,	,	PUNCT
gs-3799	533	8	these	these	DET
gs-3799	533	9	systems	system	NOUN
gs-3799	533	10	aim	aim	VERB
gs-3799	533	11	not	not	PART
gs-3799	533	12	only	only	ADV
gs-3799	533	13	to	to	PART
gs-3799	533	14	stabilize	stabilize	VERB
gs-3799	533	15	the	the	DET
gs-3799	533	16	immediate	immediate	ADJ
gs-3799	533	17	bypass	bypass	NOUN
gs-3799	533	18	window	window	NOUN
gs-3799	533	19	but	but	CCONJ
gs-3799	533	20	to	to	PART
gs-3799	533	21	reduce	reduce	VERB
gs-3799	533	22	the	the	DET
gs-3799	533	23	immunologic	immunologic	ADJ
gs-3799	533	24	sequelae	sequelae	NOUN
gs-3799	533	25	that	that	PRON
gs-3799	533	26	drive	drive	VERB
gs-3799	533	27	organ	organ	NOUN
gs-3799	533	28	dysfunction	dysfunction	NOUN
gs-3799	533	29	,	,	PUNCT
gs-3799	533	30	coagulopathy	coagulopathy	ADJ
gs-3799	533	31	,	,	PUNCT
gs-3799	533	32	and	and	CCONJ
gs-3799	533	33	postoperative	postoperative	ADJ
gs-3799	533	34	cognitive	cognitive	ADJ
gs-3799	533	35	decline	decline	NOUN
gs-3799	533	36	.	.	PUNCT
gs-3799	534	1	parallel	parallel	ADJ
gs-3799	534	2	developments	development	NOUN
gs-3799	534	3	in	in	ADP
gs-3799	534	4	cloud	cloud	NOUN
gs-3799	534	5	-	-	PUNCT
gs-3799	534	6	integrated	integrate	VERB
gs-3799	534	7	cl	cl	NOUN
gs-3799	534	8	-	-	PUNCT
gs-3799	534	9	cpb	cpb	NOUN
gs-3799	534	10	architecture	architecture	NOUN
gs-3799	534	11	have	have	AUX
gs-3799	534	12	redefined	redefine	VERB
gs-3799	534	13	the	the	DET
gs-3799	534	14	nature	nature	NOUN
gs-3799	534	15	of	of	ADP
gs-3799	534	16	surgical	surgical	ADJ
gs-3799	534	17	informatics	informatic	NOUN
gs-3799	534	18	.	.	PUNCT
gs-3799	535	1	by	by	ADP
gs-3799	535	2	streaming	stream	VERB
gs-3799	535	3	intraoperative	intraoperative	ADJ
gs-3799	535	4	data	datum	NOUN
gs-3799	535	5	to	to	PART
gs-3799	535	6	secure	secure	VERB
gs-3799	535	7	,	,	PUNCT
gs-3799	535	8	anonymized	anonymize	VERB
gs-3799	535	9	cloud	cloud	ADJ
gs-3799	535	10	environments	environment	NOUN
gs-3799	535	11	,	,	PUNCT
gs-3799	535	12	systems	system	NOUN
gs-3799	535	13	can	can	AUX
gs-3799	535	14	train	train	VERB
gs-3799	535	15	themselves	themselves	PRON
gs-3799	535	16	across	across	ADP
gs-3799	535	17	global	global	ADJ
gs-3799	535	18	procedural	procedural	ADJ
gs-3799	535	19	datasets	dataset	NOUN
gs-3799	535	20	.	.	PUNCT
gs-3799	536	1	the	the	DET
gs-3799	536	2	advantage	advantage	NOUN
gs-3799	536	3	of	of	ADP
gs-3799	536	4	this	this	DET
gs-3799	536	5	infrastructure	infrastructure	NOUN
gs-3799	536	6	is	be	AUX
gs-3799	536	7	twofold	twofold	ADV
gs-3799	536	8	:	:	PUNCT
gs-3799	536	9	first	first	ADV
gs-3799	536	10	,	,	PUNCT
gs-3799	536	11	it	it	PRON
gs-3799	536	12	allows	allow	VERB
gs-3799	536	13	for	for	ADP
gs-3799	536	14	federated	federated	ADJ
gs-3799	536	15	learning	learning	NOUN
gs-3799	536	16	—	—	PUNCT
gs-3799	536	17	where	where	SCONJ
gs-3799	536	18	algorithms	algorithm	NOUN
gs-3799	536	19	improve	improve	VERB
gs-3799	536	20	without	without	ADP
gs-3799	536	21	ever	ever	ADV
gs-3799	536	22	needing	need	VERB
gs-3799	536	23	access	access	NOUN
gs-3799	536	24	to	to	ADP
gs-3799	536	25	raw	raw	ADJ
gs-3799	536	26	patient	patient	NOUN
gs-3799	536	27	data	datum	NOUN
gs-3799	536	28	.	.	PUNCT
gs-3799	537	1	second	second	ADJ
gs-3799	537	2	,	,	PUNCT
gs-3799	537	3	it	it	PRON
gs-3799	537	4	supports	support	VERB
gs-3799	537	5	real	real	ADJ
gs-3799	537	6	-	-	PUNCT
gs-3799	537	7	time	time	NOUN
gs-3799	537	8	expert	expert	NOUN
gs-3799	537	9	augmentation	augmentation	NOUN
gs-3799	537	10	,	,	PUNCT
gs-3799	537	11	wherein	wherein	SCONJ
gs-3799	537	12	clinicians	clinician	NOUN
gs-3799	537	13	at	at	ADP
gs-3799	537	14	tertiary	tertiary	ADJ
gs-3799	537	15	centers	center	NOUN
gs-3799	537	16	can	can	AUX
gs-3799	537	17	monitor	monitor	VERB
gs-3799	537	18	and	and	CCONJ
gs-3799	537	19	advice	advice	NOUN
gs-3799	537	20	on	on	ADP
gs-3799	537	21	procedures	procedure	NOUN
gs-3799	537	22	being	be	AUX
gs-3799	537	23	conducted	conduct	VERB
gs-3799	537	24	in	in	ADP
gs-3799	537	25	remote	remote	ADJ
gs-3799	537	26	environments	environment	NOUN
gs-3799	537	27	.	.	PUNCT
gs-3799	538	1	in	in	ADP
gs-3799	538	2	this	this	DET
gs-3799	538	3	context	context	NOUN
gs-3799	538	4	,	,	PUNCT
gs-3799	538	5	cl	cl	NOUN
gs-3799	538	6	-	-	PUNCT
gs-3799	538	7	cpb	cpb	NOUN
gs-3799	538	8	becomes	become	VERB
gs-3799	538	9	not	not	PART
gs-3799	538	10	just	just	ADV
gs-3799	538	11	a	a	DET
gs-3799	538	12	tool	tool	NOUN
gs-3799	538	13	but	but	CCONJ
gs-3799	538	14	a	a	DET
gs-3799	538	15	distributed	distribute	VERB
gs-3799	538	16	knowledge	knowledge	NOUN
gs-3799	538	17	node	node	NOUN
gs-3799	538	18	,	,	PUNCT
gs-3799	538	19	embodying	embody	VERB
gs-3799	538	20	the	the	DET
gs-3799	538	21	collective	collective	ADJ
gs-3799	538	22	intelligence	intelligence	NOUN
gs-3799	538	23	of	of	ADP
gs-3799	538	24	the	the	DET
gs-3799	538	25	cardiothoracic	cardiothoracic	NOUN
gs-3799	538	26	community	community	NOUN
gs-3799	538	27	.	.	PUNCT
gs-3799	539	1	further	further	ADJ
gs-3799	539	2	attention	attention	NOUN
gs-3799	539	3	must	must	AUX
gs-3799	539	4	be	be	AUX
gs-3799	539	5	paid	pay	VERB
gs-3799	539	6	to	to	ADP
gs-3799	539	7	the	the	DET
gs-3799	539	8	bioethical	bioethical	ADJ
gs-3799	539	9	ramifications	ramification	NOUN
gs-3799	539	10	of	of	ADP
gs-3799	539	11	algorithmic	algorithmic	ADJ
gs-3799	539	12	autonomy	autonomy	NOUN
gs-3799	539	13	during	during	ADP
gs-3799	539	14	high	high	ADJ
gs-3799	539	15	-	-	PUNCT
gs-3799	539	16	stakes	stake	NOUN
gs-3799	539	17	surgery	surgery	NOUN
gs-3799	539	18	.	.	PUNCT
gs-3799	540	1	as	as	SCONJ
gs-3799	540	2	closed	closed	ADJ
gs-3799	540	3	-	-	PUNCT
gs-3799	540	4	loop	loop	NOUN
gs-3799	540	5	systems	system	NOUN
gs-3799	540	6	evolve	evolve	VERB
gs-3799	540	7	from	from	ADP
gs-3799	540	8	assistive	assistive	ADJ
gs-3799	540	9	to	to	ADP
gs-3799	540	10	directive	directive	NOUN
gs-3799	540	11	,	,	PUNCT
gs-3799	540	12	the	the	DET
gs-3799	540	13	question	question	NOUN
gs-3799	540	14	arises	arise	VERB
gs-3799	540	15	:	:	PUNCT
gs-3799	540	16	who	who	PRON
gs-3799	540	17	holds	hold	VERB
gs-3799	540	18	ultimate	ultimate	ADJ
gs-3799	540	19	responsibility	responsibility	NOUN
gs-3799	540	20	for	for	ADP
gs-3799	540	21	intraoperative	intraoperative	ADJ
gs-3799	540	22	decision	decision	NOUN
gs-3799	540	23	-	-	PUNCT
gs-3799	540	24	making	making	NOUN
gs-3799	540	25	?	?	PUNCT
gs-3799	541	1	models	model	NOUN
gs-3799	541	2	of	of	ADP
gs-3799	541	3	shared	share	VERB
gs-3799	541	4	decision	decision	NOUN
gs-3799	541	5	architecture	architecture	NOUN
gs-3799	541	6	are	be	AUX
gs-3799	541	7	being	be	AUX
gs-3799	541	8	proposed	propose	VERB
gs-3799	541	9	,	,	PUNCT
gs-3799	541	10	where	where	SCONJ
gs-3799	541	11	system	system	NOUN
gs-3799	541	12	behavior	behavior	NOUN
gs-3799	541	13	is	be	AUX
gs-3799	541	14	constrained	constrain	VERB
gs-3799	541	15	within	within	ADP
gs-3799	541	16	a	a	DET
gs-3799	541	17	clinician	clinician	NOUN
gs-3799	541	18	-	-	PUNCT
gs-3799	541	19	defined	define	VERB
gs-3799	541	20	ethical	ethical	ADJ
gs-3799	541	21	boundary	boundary	NOUN
gs-3799	541	22	(	(	PUNCT
gs-3799	541	23	e.g.	e.g.	ADV
gs-3799	541	24	,	,	PUNCT
gs-3799	541	25	maximum	maximum	ADJ
gs-3799	541	26	allowable	allowable	ADJ
gs-3799	541	27	dose	dose	NOUN
gs-3799	541	28	,	,	PUNCT
gs-3799	541	29	no	no	DET
gs-3799	541	30	automated	automate	VERB
gs-3799	541	31	cardiac	cardiac	ADJ
gs-3799	541	32	arrest	arrest	NOUN
gs-3799	541	33	reversal	reversal	NOUN
gs-3799	541	34	)	)	PUNCT
gs-3799	541	35	.	.	PUNCT
gs-3799	542	1	transparent	transparent	ADJ
gs-3799	542	2	audit	audit	NOUN
gs-3799	542	3	trails	trail	NOUN
gs-3799	542	4	,	,	PUNCT
gs-3799	542	5	explainable	explainable	ADJ
gs-3799	542	6	ai	ai	NOUN
gs-3799	542	7	(	(	PUNCT
gs-3799	542	8	xai	xai	PROPN
gs-3799	542	9	)	)	PUNCT
gs-3799	542	10	layers	layer	NOUN
gs-3799	542	11	,	,	PUNCT
gs-3799	542	12	and	and	CCONJ
gs-3799	542	13	“	"	PUNCT
gs-3799	542	14	black	black	ADJ
gs-3799	542	15	box	box	NOUN
gs-3799	542	16	recorders	recorder	NOUN
gs-3799	542	17	”	"	PUNCT
gs-3799	542	18	have	have	AUX
gs-3799	542	19	become	become	VERB
gs-3799	542	20	essential	essential	ADJ
gs-3799	542	21	for	for	ADP
gs-3799	542	22	postprocedural	postprocedural	ADJ
gs-3799	542	23	forensic	forensic	ADJ
gs-3799	542	24	analysis	analysis	NOUN
gs-3799	542	25	,	,	PUNCT
gs-3799	542	26	particularly	particularly	ADV
gs-3799	542	27	in	in	ADP
gs-3799	542	28	the	the	DET
gs-3799	542	29	rare	rare	ADJ
gs-3799	542	30	but	but	CCONJ
gs-3799	542	31	inevitable	inevitable	ADJ
gs-3799	542	32	cases	case	NOUN
gs-3799	542	33	of	of	ADP
gs-3799	542	34	adverse	adverse	ADJ
gs-3799	542	35	outcomes	outcome	NOUN
gs-3799	542	36	.	.	PUNCT
gs-3799	543	1	the	the	DET
gs-3799	543	2	exploration	exploration	NOUN
gs-3799	543	3	of	of	ADP
gs-3799	543	4	microperfusion	microperfusion	NOUN
gs-3799	543	5	modulation	modulation	NOUN
gs-3799	543	6	at	at	ADP
gs-3799	543	7	the	the	DET
gs-3799	543	8	capillary	capillary	ADJ
gs-3799	543	9	level	level	NOUN
gs-3799	543	10	is	be	AUX
gs-3799	543	11	another	another	DET
gs-3799	543	12	emerging	emerge	VERB
gs-3799	543	13	horizon	horizon	NOUN
gs-3799	543	14	.	.	PUNCT
gs-3799	544	1	most	most	ADJ
gs-3799	544	2	cpb	cpb	PROPN
gs-3799	544	3	systems	system	NOUN
gs-3799	544	4	operate	operate	VERB
gs-3799	544	5	with	with	ADP
gs-3799	544	6	macro	macro	ADJ
gs-3799	544	7	-	-	NOUN
gs-3799	544	8	level	level	NOUN
gs-3799	544	9	targets	target	NOUN
gs-3799	544	10	:	:	PUNCT
gs-3799	544	11	map	map	NOUN
gs-3799	544	12	,	,	PUNCT
gs-3799	544	13	flow	flow	NOUN
gs-3799	544	14	index	index	NOUN
gs-3799	544	15	,	,	PUNCT
gs-3799	544	16	saturation	saturation	NOUN
gs-3799	544	17	.	.	PUNCT
gs-3799	545	1	however	however	ADV
gs-3799	545	2	,	,	PUNCT
gs-3799	545	3	emerging	emerge	VERB
gs-3799	545	4	sensor	sensor	NOUN
gs-3799	545	5	technologies	technology	NOUN
gs-3799	545	6	—	—	PUNCT
gs-3799	545	7	such	such	ADJ
gs-3799	545	8	as	as	ADP
gs-3799	545	9	sublingual	sublingual	ADJ
gs-3799	545	10	videomicroscopy	videomicroscopy	NOUN
gs-3799	545	11	and	and	CCONJ
gs-3799	545	12	tissue	tissue	NOUN
gs-3799	545	13	micro	micro	NOUN
gs-3799	545	14	-	-	NOUN
gs-3799	545	15	oximetry	oximetry	NOUN
gs-3799	545	16	—	—	PUNCT
gs-3799	545	17	allow	allow	VERB
gs-3799	545	18	for	for	ADP
gs-3799	545	19	real	real	ADJ
gs-3799	545	20	-	-	PUNCT
gs-3799	545	21	time	time	NOUN
gs-3799	545	22	insight	insight	NOUN
gs-3799	545	23	into	into	ADP
gs-3799	545	24	regional	regional	ADJ
gs-3799	545	25	perfusion	perfusion	NOUN
gs-3799	545	26	heterogeneity	heterogeneity	NOUN
gs-3799	545	27	.	.	PUNCT
gs-3799	546	1	this	this	DET
gs-3799	546	2	data	datum	NOUN
gs-3799	546	3	can	can	AUX
gs-3799	546	4	be	be	AUX
gs-3799	546	5	fed	feed	VERB
gs-3799	546	6	into	into	ADP
gs-3799	546	7	closed	closed	ADJ
gs-3799	546	8	-	-	PUNCT
gs-3799	546	9	loop	loop	NOUN
gs-3799	546	10	georgian	georgian	NOUN
gs-3799	546	11	scientists/	scientists/	NUM
gs-3799	546	12	.	.	PUNCT
gs-3799	547	1	7	7	NUM
gs-3799	547	2	n	n	DET
gs-3799	547	3	2	2	NUM
gs-3799	547	4	,	,	PUNCT
gs-3799	547	5	2025	2025	NUM
gs-3799	547	6	407	407	NUM
gs-3799	547	7	systems	system	NOUN
gs-3799	547	8	to	to	PART
gs-3799	547	9	initiate	initiate	VERB
gs-3799	547	10	flow	flow	NOUN
gs-3799	547	11	redistribution	redistribution	NOUN
gs-3799	547	12	,	,	PUNCT
gs-3799	547	13	microvascular	microvascular	ADJ
gs-3799	547	14	vasodilator	vasodilator	NOUN
gs-3799	547	15	infusion	infusion	NOUN
gs-3799	547	16	(	(	PUNCT
gs-3799	547	17	e.g.	e.g.	ADV
gs-3799	547	18	,	,	PUNCT
gs-3799	547	19	l	l	NOUN
gs-3799	547	20	-	-	NOUN
gs-3799	547	21	arginine	arginine	NOUN
gs-3799	547	22	)	)	PUNCT
gs-3799	547	23	,	,	PUNCT
gs-3799	547	24	or	or	CCONJ
gs-3799	547	25	customized	customize	VERB
gs-3799	547	26	hematocrit	hematocrit	PROPN
gs-3799	547	27	optimization	optimization	NOUN
gs-3799	547	28	.	.	PUNCT
gs-3799	548	1	pilot	pilot	NOUN
gs-3799	548	2	studies	study	NOUN
gs-3799	548	3	show	show	VERB
gs-3799	548	4	that	that	SCONJ
gs-3799	548	5	regional	regional	ADJ
gs-3799	548	6	ischemia	ischemia	NOUN
gs-3799	548	7	markers	marker	NOUN
gs-3799	548	8	(	(	PUNCT
gs-3799	548	9	e.g.	e.g.	ADV
gs-3799	548	10	,	,	PUNCT
gs-3799	548	11	gastric	gastric	ADJ
gs-3799	548	12	pco	pco	NOUN
gs-3799	548	13	,	,	PUNCT
gs-3799	548	14	bladder	bladder	NOUN
gs-3799	548	15	temperature	temperature	NOUN
gs-3799	548	16	gradients	gradient	NOUN
gs-3799	548	17	)	)	PUNCT
gs-3799	548	18	may	may	AUX
gs-3799	548	19	rise	rise	VERB
gs-3799	548	20	while	while	SCONJ
gs-3799	548	21	systemic	systemic	ADJ
gs-3799	548	22	variables	variable	NOUN
gs-3799	548	23	remain	remain	VERB
gs-3799	548	24	nominal	nominal	ADJ
gs-3799	548	25	—	—	PUNCT
gs-3799	548	26	a	a	DET
gs-3799	548	27	disconnect	disconnect	NOUN
gs-3799	548	28	that	that	PRON
gs-3799	548	29	closed	close	VERB
gs-3799	548	30	-	-	PUNCT
gs-3799	548	31	loop	loop	NOUN
gs-3799	548	32	systems	system	NOUN
gs-3799	548	33	are	be	AUX
gs-3799	548	34	uniquely	uniquely	ADV
gs-3799	548	35	suited	suited	ADJ
gs-3799	548	36	to	to	PART
gs-3799	548	37	rectify	rectify	VERB
gs-3799	548	38	through	through	ADP
gs-3799	548	39	multi	multi	ADJ
gs-3799	548	40	-	-	ADJ
gs-3799	548	41	tiered	tiered	ADJ
gs-3799	548	42	perfusion	perfusion	NOUN
gs-3799	548	43	algorithms	algorithm	NOUN
gs-3799	548	44	.	.	PUNCT
gs-3799	549	1	the	the	DET
gs-3799	549	2	perfusionist	perfusionist	PROPN
gs-3799	549	3	’s	’s	PART
gs-3799	549	4	role	role	NOUN
gs-3799	549	5	within	within	ADP
gs-3799	549	6	a	a	DET
gs-3799	549	7	closed	closed	ADJ
gs-3799	549	8	-	-	PUNCT
gs-3799	549	9	loop	loop	NOUN
gs-3799	549	10	ecosystem	ecosystem	NOUN
gs-3799	549	11	must	must	AUX
gs-3799	549	12	be	be	AUX
gs-3799	549	13	explored	explore	VERB
gs-3799	549	14	.	.	PUNCT
gs-3799	550	1	no	no	ADV
gs-3799	550	2	longer	long	ADV
gs-3799	550	3	limited	limit	VERB
gs-3799	550	4	to	to	ADP
gs-3799	550	5	manual	manual	ADJ
gs-3799	550	6	control	control	NOUN
gs-3799	550	7	and	and	CCONJ
gs-3799	550	8	episodic	episodic	ADJ
gs-3799	550	9	data	datum	NOUN
gs-3799	550	10	interpretation	interpretation	NOUN
gs-3799	550	11	,	,	PUNCT
gs-3799	550	12	the	the	DET
gs-3799	550	13	perfusionist	perfusionist	NOUN
gs-3799	550	14	now	now	ADV
gs-3799	550	15	operates	operate	VERB
gs-3799	550	16	as	as	ADP
gs-3799	550	17	a	a	DET
gs-3799	550	18	system	system	NOUN
gs-3799	550	19	supervisor	supervisor	NOUN
gs-3799	550	20	,	,	PUNCT
gs-3799	550	21	real	real	ADJ
gs-3799	550	22	-	-	PUNCT
gs-3799	550	23	time	time	NOUN
gs-3799	550	24	model	model	NOUN
gs-3799	550	25	validator	validator	NOUN
gs-3799	550	26	,	,	PUNCT
gs-3799	550	27	and	and	CCONJ
gs-3799	550	28	human	human	ADJ
gs-3799	550	29	fail	fail	ADJ
gs-3799	550	30	-	-	PUNCT
gs-3799	550	31	safe	safe	ADJ
gs-3799	550	32	.	.	PUNCT
gs-3799	551	1	training	training	NOUN
gs-3799	551	2	programs	program	NOUN
gs-3799	551	3	are	be	AUX
gs-3799	551	4	being	be	AUX
gs-3799	551	5	redesigned	redesign	VERB
gs-3799	551	6	to	to	PART
gs-3799	551	7	include	include	VERB
gs-3799	551	8	coding	code	VERB
gs-3799	551	9	fundamentals	fundamental	NOUN
gs-3799	551	10	,	,	PUNCT
gs-3799	551	11	system	system	NOUN
gs-3799	551	12	diagnostics	diagnostic	NOUN
gs-3799	551	13	,	,	PUNCT
gs-3799	551	14	and	and	CCONJ
gs-3799	551	15	ai	ai	VERB
gs-3799	551	16	ethics	ethic	NOUN
gs-3799	551	17	,	,	PUNCT
gs-3799	551	18	transforming	transform	VERB
gs-3799	551	19	the	the	DET
gs-3799	551	20	perfusionist	perfusionist	NOUN
gs-3799	551	21	into	into	ADP
gs-3799	551	22	a	a	DET
gs-3799	551	23	hybrid	hybrid	NOUN
gs-3799	551	24	of	of	ADP
gs-3799	551	25	clinician	clinician	NOUN
gs-3799	551	26	,	,	PUNCT
gs-3799	551	27	data	datum	NOUN
gs-3799	551	28	scientist	scientist	NOUN
gs-3799	551	29	,	,	PUNCT
gs-3799	551	30	and	and	CCONJ
gs-3799	551	31	procedural	procedural	ADJ
gs-3799	551	32	strategist	strategist	NOUN
gs-3799	551	33	.	.	PUNCT
gs-3799	552	1	this	this	DET
gs-3799	552	2	reprofessionalization	reprofessionalization	NOUN
gs-3799	552	3	parallels	parallel	VERB
gs-3799	552	4	similar	similar	ADJ
gs-3799	552	5	transitions	transition	NOUN
gs-3799	552	6	seen	see	VERB
gs-3799	552	7	in	in	ADP
gs-3799	552	8	aviation	aviation	NOUN
gs-3799	552	9	,	,	PUNCT
gs-3799	552	10	radiology	radiology	NOUN
gs-3799	552	11	,	,	PUNCT
gs-3799	552	12	and	and	CCONJ
gs-3799	552	13	robotic	robotic	ADJ
gs-3799	552	14	surgery	surgery	NOUN
gs-3799	552	15	,	,	PUNCT
gs-3799	552	16	where	where	SCONJ
gs-3799	552	17	technological	technological	ADJ
gs-3799	552	18	augmentation	augmentation	NOUN
gs-3799	552	19	has	have	AUX
gs-3799	552	20	expanded	expand	VERB
gs-3799	552	21	rather	rather	ADV
gs-3799	552	22	than	than	ADP
gs-3799	552	23	displaced	displace	VERB
gs-3799	552	24	human	human	ADJ
gs-3799	552	25	roles	role	NOUN
gs-3799	552	26	.	.	PUNCT
gs-3799	553	1	the	the	DET
gs-3799	553	2	new	new	ADJ
gs-3799	553	3	phase	phase	NOUN
gs-3799	553	4	of	of	ADP
gs-3799	553	5	closed	closed	ADJ
gs-3799	553	6	-	-	PUNCT
gs-3799	553	7	loop	loop	NOUN
gs-3799	553	8	cpb	cpb	PROPN
gs-3799	553	9	development	development	NOUN
gs-3799	553	10	is	be	AUX
gs-3799	553	11	not	not	PART
gs-3799	553	12	merely	merely	ADV
gs-3799	553	13	a	a	DET
gs-3799	553	14	technological	technological	ADJ
gs-3799	553	15	upgrade	upgrade	NOUN
gs-3799	553	16	but	but	CCONJ
gs-3799	553	17	a	a	DET
gs-3799	553	18	paradigmatic	paradigmatic	ADJ
gs-3799	553	19	reorientation	reorientation	NOUN
gs-3799	553	20	.	.	PUNCT
gs-3799	554	1	the	the	DET
gs-3799	554	2	integration	integration	NOUN
gs-3799	554	3	of	of	ADP
gs-3799	554	4	cybernetic	cybernetic	ADJ
gs-3799	554	5	logic	logic	NOUN
gs-3799	554	6	,	,	PUNCT
gs-3799	554	7	molecular	molecular	ADJ
gs-3799	554	8	feedback	feedback	NOUN
gs-3799	554	9	,	,	PUNCT
gs-3799	554	10	neurocognitive	neurocognitive	ADJ
gs-3799	554	11	preservation	preservation	NOUN
gs-3799	554	12	,	,	PUNCT
gs-3799	554	13	latency	latency	NOUN
gs-3799	554	14	engineering	engineering	NOUN
gs-3799	554	15	,	,	PUNCT
gs-3799	554	16	and	and	CCONJ
gs-3799	554	17	distributed	distribute	VERB
gs-3799	554	18	intelligence	intelligence	NOUN
gs-3799	554	19	transforms	transform	VERB
gs-3799	554	20	the	the	DET
gs-3799	554	21	operating	operating	NOUN
gs-3799	554	22	room	room	NOUN
gs-3799	554	23	from	from	ADP
gs-3799	554	24	a	a	DET
gs-3799	554	25	site	site	NOUN
gs-3799	554	26	of	of	ADP
gs-3799	554	27	reactive	reactive	ADJ
gs-3799	554	28	intervention	intervention	NOUN
gs-3799	554	29	to	to	ADP
gs-3799	554	30	one	one	NUM
gs-3799	554	31	of	of	ADP
gs-3799	554	32	predictive	predictive	ADJ
gs-3799	554	33	physiological	physiological	ADJ
gs-3799	554	34	orchestration	orchestration	NOUN
gs-3799	554	35	.	.	PUNCT
gs-3799	555	1	the	the	DET
gs-3799	555	2	implications	implication	NOUN
gs-3799	555	3	for	for	ADP
gs-3799	555	4	surgical	surgical	ADJ
gs-3799	555	5	outcomes	outcome	NOUN
gs-3799	555	6	,	,	PUNCT
gs-3799	555	7	system	system	NOUN
gs-3799	555	8	resilience	resilience	NOUN
gs-3799	555	9	,	,	PUNCT
gs-3799	555	10	and	and	CCONJ
gs-3799	555	11	global	global	ADJ
gs-3799	555	12	equity	equity	NOUN
gs-3799	555	13	are	be	AUX
gs-3799	555	14	profound	profound	ADJ
gs-3799	555	15	—	—	PUNCT
gs-3799	555	16	and	and	CCONJ
gs-3799	555	17	demand	demand	VERB
gs-3799	555	18	continued	continue	VERB
gs-3799	555	19	interrogation	interrogation	NOUN
gs-3799	555	20	across	across	ADP
gs-3799	555	21	disciplines	discipline	NOUN
gs-3799	555	22	losed	lose	VERB
gs-3799	555	23	-	-	PUNCT
gs-3799	555	24	loop	loop	NOUN
gs-3799	555	25	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	555	26	bypass	bypass	NOUN
gs-3799	555	27	(	(	PUNCT
gs-3799	555	28	cl	cl	NOUN
gs-3799	555	29	-	-	PUNCT
gs-3799	555	30	cpb	cpb	NOUN
gs-3799	555	31	)	)	PUNCT
gs-3799	555	32	systems	system	NOUN
gs-3799	555	33	are	be	AUX
gs-3799	555	34	undergoing	undergo	VERB
gs-3799	555	35	a	a	DET
gs-3799	555	36	fundamental	fundamental	ADJ
gs-3799	555	37	transformation	transformation	NOUN
gs-3799	555	38	not	not	PART
gs-3799	555	39	only	only	ADV
gs-3799	555	40	in	in	ADP
gs-3799	555	41	technical	technical	ADJ
gs-3799	555	42	architecture	architecture	NOUN
gs-3799	555	43	but	but	CCONJ
gs-3799	555	44	also	also	ADV
gs-3799	555	45	in	in	ADP
gs-3799	555	46	their	their	PRON
gs-3799	555	47	epistemological	epistemological	ADJ
gs-3799	555	48	foundation	foundation	NOUN
gs-3799	555	49	.	.	PUNCT
gs-3799	556	1	with	with	ADP
gs-3799	556	2	the	the	DET
gs-3799	556	3	advent	advent	NOUN
gs-3799	556	4	of	of	ADP
gs-3799	556	5	bio	bio	ADJ
gs-3799	556	6	-	-	ADJ
gs-3799	556	7	intelligent	intelligent	ADJ
gs-3799	556	8	design	design	NOUN
gs-3799	556	9	and	and	CCONJ
gs-3799	556	10	autonomous	autonomous	ADJ
gs-3799	556	11	physiologic	physiologic	ADJ
gs-3799	556	12	emulation	emulation	NOUN
gs-3799	556	13	,	,	PUNCT
gs-3799	556	14	the	the	DET
gs-3799	556	15	modern	modern	ADJ
gs-3799	556	16	cl	cl	ADJ
gs-3799	556	17	-	-	PUNCT
gs-3799	556	18	cpb	cpb	NOUN
gs-3799	556	19	system	system	NOUN
gs-3799	556	20	is	be	AUX
gs-3799	556	21	no	no	ADV
gs-3799	556	22	longer	long	ADV
gs-3799	556	23	a	a	DET
gs-3799	556	24	mere	mere	ADJ
gs-3799	556	25	controller	controller	NOUN
gs-3799	556	26	—	—	PUNCT
gs-3799	556	27	it	it	PRON
gs-3799	556	28	is	be	AUX
gs-3799	556	29	becoming	become	VERB
gs-3799	556	30	a	a	DET
gs-3799	556	31	predictive	predictive	ADJ
gs-3799	556	32	,	,	PUNCT
gs-3799	556	33	responsive	responsive	ADJ
gs-3799	556	34	,	,	PUNCT
gs-3799	556	35	and	and	CCONJ
gs-3799	556	36	anticipatory	anticipatory	ADJ
gs-3799	556	37	agent	agent	NOUN
gs-3799	556	38	.	.	PUNCT
gs-3799	557	1	this	this	PRON
gs-3799	557	2	expanded	expand	VERB
gs-3799	557	3	results	result	NOUN
gs-3799	557	4	&	&	CCONJ
gs-3799	557	5	discussion	discussion	NOUN
gs-3799	557	6	section	section	NOUN
gs-3799	557	7	delineates	delineate	VERB
gs-3799	557	8	the	the	DET
gs-3799	557	9	cutting	cut	VERB
gs-3799	557	10	edge	edge	NOUN
gs-3799	557	11	of	of	ADP
gs-3799	557	12	closedloop	closedloop	NOUN
gs-3799	557	13	cardiovascular	cardiovascular	ADJ
gs-3799	557	14	regulation	regulation	NOUN
gs-3799	557	15	through	through	ADP
gs-3799	557	16	a	a	DET
gs-3799	557	17	deeply	deeply	ADV
gs-3799	557	18	interdisciplinary	interdisciplinary	ADJ
gs-3799	557	19	lens	len	NOUN
gs-3799	557	20	,	,	PUNCT
gs-3799	557	21	revealing	reveal	VERB
gs-3799	557	22	emergent	emergent	ADJ
gs-3799	557	23	system	system	NOUN
gs-3799	557	24	features	feature	NOUN
gs-3799	557	25	,	,	PUNCT
gs-3799	557	26	translational	translational	ADJ
gs-3799	557	27	innovations	innovation	NOUN
gs-3799	557	28	,	,	PUNCT
gs-3799	557	29	and	and	CCONJ
gs-3799	557	30	future	future	ADJ
gs-3799	557	31	integrative	integrative	ADJ
gs-3799	557	32	trajectories	trajectory	NOUN
gs-3799	557	33	.	.	PUNCT
gs-3799	558	1	emergent	emergent	ADJ
gs-3799	558	2	behavior	behavior	NOUN
gs-3799	558	3	in	in	ADP
gs-3799	558	4	complex	complex	ADJ
gs-3799	558	5	biological	biological	ADJ
gs-3799	558	6	systems	system	NOUN
gs-3799	558	7	and	and	CCONJ
gs-3799	558	8	systemic	systemic	ADJ
gs-3799	558	9	stability	stability	NOUN
gs-3799	558	10	:	:	PUNCT
gs-3799	558	11	cl	cl	NOUN
gs-3799	558	12	-	-	PUNCT
gs-3799	558	13	cpb	cpb	NOUN
gs-3799	558	14	must	must	AUX
gs-3799	558	15	operate	operate	VERB
gs-3799	558	16	in	in	ADP
gs-3799	558	17	a	a	DET
gs-3799	558	18	space	space	NOUN
gs-3799	558	19	defined	define	VERB
gs-3799	558	20	not	not	PART
gs-3799	558	21	by	by	ADP
gs-3799	558	22	linear	linear	ADJ
gs-3799	558	23	feedback	feedback	NOUN
gs-3799	558	24	loops	loop	NOUN
gs-3799	558	25	,	,	PUNCT
gs-3799	558	26	but	but	CCONJ
gs-3799	558	27	by	by	ADP
gs-3799	558	28	biologically	biologically	ADV
gs-3799	558	29	nonlinear	nonlinear	ADJ
gs-3799	558	30	,	,	PUNCT
gs-3799	558	31	chaotic	chaotic	ADJ
gs-3799	558	32	systems	system	NOUN
gs-3799	558	33	,	,	PUNCT
gs-3799	558	34	where	where	SCONJ
gs-3799	558	35	small	small	ADJ
gs-3799	558	36	perturbations	perturbation	NOUN
gs-3799	558	37	in	in	ADP
gs-3799	558	38	temperature	temperature	NOUN
gs-3799	558	39	,	,	PUNCT
gs-3799	558	40	volume	volume	NOUN
gs-3799	558	41	status	status	NOUN
gs-3799	558	42	,	,	PUNCT
gs-3799	558	43	or	or	CCONJ
gs-3799	558	44	systemic	systemic	ADJ
gs-3799	558	45	vascular	vascular	ADJ
gs-3799	558	46	resistance	resistance	NOUN
gs-3799	558	47	can	can	AUX
gs-3799	558	48	yield	yield	VERB
gs-3799	558	49	disproportionately	disproportionately	ADV
gs-3799	558	50	large	large	ADJ
gs-3799	558	51	effects	effect	NOUN
gs-3799	558	52	.	.	PUNCT
gs-3799	559	1	traditional	traditional	ADJ
gs-3799	559	2	control	control	NOUN
gs-3799	559	3	architectures	architecture	NOUN
gs-3799	559	4	—	—	PUNCT
gs-3799	559	5	based	base	VERB
gs-3799	559	6	on	on	ADP
gs-3799	559	7	proportional	proportional	ADJ
gs-3799	559	8	-	-	PUNCT
gs-3799	559	9	integralderivative	integralderivative	ADJ
gs-3799	559	10	(	(	PUNCT
gs-3799	559	11	pid	pid	NOUN
gs-3799	559	12	)	)	PUNCT
gs-3799	559	13	logic	logic	NOUN
gs-3799	559	14	—	—	PUNCT
gs-3799	559	15	are	be	AUX
gs-3799	559	16	fundamentally	fundamentally	ADV
gs-3799	559	17	insufficient	insufficient	ADJ
gs-3799	559	18	to	to	PART
gs-3799	559	19	govern	govern	VERB
gs-3799	559	20	these	these	DET
gs-3799	559	21	dynamics	dynamic	NOUN
gs-3799	559	22	.	.	PUNCT
gs-3799	560	1	instead	instead	ADV
gs-3799	560	2	,	,	PUNCT
gs-3799	560	3	cl	cl	NOUN
gs-3799	560	4	-	-	PUNCT
gs-3799	560	5	cpb	cpb	NOUN
gs-3799	560	6	platforms	platform	NOUN
gs-3799	560	7	are	be	AUX
gs-3799	560	8	adopting	adopt	VERB
gs-3799	560	9	adaptive	adaptive	ADJ
gs-3799	560	10	fuzzy	fuzzy	ADJ
gs-3799	560	11	logic	logic	NOUN
gs-3799	560	12	controllers	controller	NOUN
gs-3799	560	13	(	(	PUNCT
gs-3799	560	14	aflcs	aflcs	PROPN
gs-3799	560	15	)	)	PUNCT
gs-3799	560	16	,	,	PUNCT
gs-3799	560	17	which	which	PRON
gs-3799	560	18	emulate	emulate	VERB
gs-3799	560	19	the	the	DET
gs-3799	560	20	approximate	approximate	ADJ
gs-3799	560	21	reasoning	reasoning	NOUN
gs-3799	560	22	of	of	ADP
gs-3799	560	23	biological	biological	ADJ
gs-3799	560	24	systems	system	NOUN
gs-3799	560	25	.	.	PUNCT
gs-3799	561	1	these	these	DET
gs-3799	561	2	controllers	controller	NOUN
gs-3799	561	3	do	do	AUX
gs-3799	561	4	not	not	PART
gs-3799	561	5	target	target	VERB
gs-3799	561	6	specific	specific	ADJ
gs-3799	561	7	values	value	NOUN
gs-3799	561	8	per	per	ADP
gs-3799	561	9	se	se	X
gs-3799	561	10	but	but	CCONJ
gs-3799	561	11	operate	operate	VERB
gs-3799	561	12	within	within	ADP
gs-3799	561	13	defined	define	VERB
gs-3799	561	14	homeodynamic	homeodynamic	ADJ
gs-3799	561	15	envelopes	envelope	NOUN
gs-3799	561	16	,	,	PUNCT
gs-3799	561	17	maintaining	maintain	VERB
gs-3799	561	18	physiological	physiological	ADJ
gs-3799	561	19	coherence	coherence	NOUN
gs-3799	561	20	even	even	ADV
gs-3799	561	21	in	in	ADP
gs-3799	561	22	the	the	DET
gs-3799	561	23	presence	presence	NOUN
gs-3799	561	24	of	of	ADP
gs-3799	561	25	highdimensional	highdimensional	ADJ
gs-3799	561	26	variability	variability	NOUN
gs-3799	561	27	.	.	PUNCT
gs-3799	562	1	systemic	systemic	ADJ
gs-3799	562	2	stability	stability	NOUN
gs-3799	562	3	is	be	AUX
gs-3799	562	4	now	now	ADV
gs-3799	562	5	analyzed	analyze	VERB
gs-3799	562	6	through	through	ADP
gs-3799	562	7	dynamical	dynamical	ADJ
gs-3799	562	8	phase	phase	NOUN
gs-3799	562	9	-	-	PUNCT
gs-3799	562	10	space	space	NOUN
gs-3799	562	11	mapping	mapping	NOUN
gs-3799	562	12	,	,	PUNCT
gs-3799	562	13	where	where	SCONJ
gs-3799	562	14	real	real	ADJ
gs-3799	562	15	-	-	PUNCT
gs-3799	562	16	time	time	NOUN
gs-3799	562	17	patient	patient	ADJ
gs-3799	562	18	state	state	NOUN
gs-3799	562	19	trajectories	trajectory	NOUN
gs-3799	562	20	are	be	AUX
gs-3799	562	21	projected	project	VERB
gs-3799	562	22	into	into	ADP
gs-3799	562	23	multidimensional	multidimensional	ADJ
gs-3799	562	24	physiological	physiological	ADJ
gs-3799	562	25	maps	map	NOUN
gs-3799	562	26	.	.	PUNCT
gs-3799	563	1	here	here	ADV
gs-3799	563	2	,	,	PUNCT
gs-3799	563	3	control	control	NOUN
gs-3799	563	4	decisions	decision	NOUN
gs-3799	563	5	are	be	AUX
gs-3799	563	6	not	not	PART
gs-3799	563	7	binary	binary	ADJ
gs-3799	563	8	but	but	CCONJ
gs-3799	563	9	rather	rather	ADV
gs-3799	563	10	probabilistic	probabilistic	ADJ
gs-3799	563	11	—	—	PUNCT
gs-3799	563	12	optimized	optimize	VERB
gs-3799	563	13	by	by	ADP
gs-3799	563	14	minimizing	minimize	VERB
gs-3799	563	15	entropy	entropy	NOUN
gs-3799	563	16	across	across	ADP
gs-3799	563	17	a	a	DET
gs-3799	563	18	set	set	NOUN
gs-3799	563	19	of	of	ADP
gs-3799	563	20	physiological	physiological	ADJ
gs-3799	563	21	attractors	attractor	NOUN
gs-3799	563	22	.	.	PUNCT
gs-3799	564	1	early	early	ADJ
gs-3799	564	2	clinical	clinical	ADJ
gs-3799	564	3	simulations	simulation	NOUN
gs-3799	564	4	suggest	suggest	VERB
gs-3799	564	5	this	this	DET
gs-3799	564	6	strategy	strategy	NOUN
gs-3799	564	7	enhances	enhance	VERB
gs-3799	564	8	microcirculatory	microcirculatory	ADJ
gs-3799	564	9	resilience	resilience	NOUN
gs-3799	564	10	and	and	CCONJ
gs-3799	564	11	reduces	reduce	VERB
gs-3799	564	12	the	the	DET
gs-3799	564	13	incidence	incidence	NOUN
gs-3799	564	14	of	of	ADP
gs-3799	564	15	organ	organ	NOUN
gs-3799	564	16	-	-	PUNCT
gs-3799	564	17	specific	specific	ADJ
gs-3799	564	18	hypoperfusion	hypoperfusion	NOUN
gs-3799	564	19	syndromes	syndrome	NOUN
gs-3799	564	20	.	.	PUNCT
gs-3799	565	1	digital	digital	ADJ
gs-3799	565	2	twins	twin	NOUN
gs-3799	565	3	and	and	CCONJ
gs-3799	565	4	predictive	predictive	ADJ
gs-3799	565	5	bio	bio	NOUN
gs-3799	565	6	-	-	NOUN
gs-3799	565	7	simulation	simulation	NOUN
gs-3799	565	8	in	in	ADP
gs-3799	565	9	closed	closed	ADJ
gs-3799	565	10	-	-	PUNCT
gs-3799	565	11	loop	loop	NOUN
gs-3799	565	12	architecture	architecture	NOUN
gs-3799	565	13	:	:	PUNCT
gs-3799	565	14	among	among	ADP
gs-3799	565	15	the	the	DET
gs-3799	565	16	most	most	ADV
gs-3799	565	17	revolutionary	revolutionary	ADJ
gs-3799	565	18	developments	development	NOUN
gs-3799	565	19	is	be	AUX
gs-3799	565	20	the	the	DET
gs-3799	565	21	integration	integration	NOUN
gs-3799	565	22	of	of	ADP
gs-3799	565	23	digital	digital	ADJ
gs-3799	565	24	twin	twin	ADJ
gs-3799	565	25	models	model	NOUN
gs-3799	565	26	—	—	PUNCT
gs-3799	565	27	high	high	ADJ
gs-3799	565	28	-	-	PUNCT
gs-3799	565	29	fidelity	fidelity	NOUN
gs-3799	565	30	,	,	PUNCT
gs-3799	565	31	continuously	continuously	ADV
gs-3799	565	32	updating	update	VERB
gs-3799	565	33	computational	computational	ADJ
gs-3799	565	34	replicas	replica	NOUN
gs-3799	565	35	of	of	ADP
gs-3799	565	36	the	the	DET
gs-3799	565	37	patient	patient	NOUN
gs-3799	565	38	’s	’s	PART
gs-3799	565	39	physiological	physiological	ADJ
gs-3799	565	40	state	state	NOUN
gs-3799	565	41	.	.	PUNCT
gs-3799	566	1	these	these	DET
gs-3799	566	2	twins	twin	NOUN
gs-3799	566	3	incorporate	incorporate	VERB
gs-3799	566	4	preoperative	preoperative	ADJ
gs-3799	566	5	imaging	imaging	NOUN
gs-3799	566	6	,	,	PUNCT
gs-3799	566	7	laboratory	laboratory	NOUN
gs-3799	566	8	profiles	profile	NOUN
gs-3799	566	9	,	,	PUNCT
gs-3799	566	10	historical	historical	ADJ
gs-3799	566	11	biometric	biometric	ADJ
gs-3799	566	12	data	datum	NOUN
gs-3799	566	13	,	,	PUNCT
gs-3799	566	14	and	and	CCONJ
gs-3799	566	15	intraoperative	intraoperative	ADJ
gs-3799	566	16	telemetry	telemetry	NOUN
gs-3799	566	17	to	to	PART
gs-3799	566	18	simulate	simulate	VERB
gs-3799	566	19	response	response	NOUN
gs-3799	566	20	to	to	ADP
gs-3799	566	21	various	various	ADJ
gs-3799	566	22	interventions	intervention	NOUN
gs-3799	566	23	before	before	SCONJ
gs-3799	566	24	they	they	PRON
gs-3799	566	25	are	be	AUX
gs-3799	566	26	implemented	implement	VERB
gs-3799	566	27	.	.	PUNCT
gs-3799	567	1	unlike	unlike	ADP
gs-3799	567	2	static	static	ADJ
gs-3799	567	3	simulation	simulation	NOUN
gs-3799	567	4	georgian	georgian	NOUN
gs-3799	567	5	scientists/	scientists/	NUM
gs-3799	567	6	.	.	PUNCT
gs-3799	568	1	7	7	NUM
gs-3799	568	2	n	n	DET
gs-3799	568	3	2	2	NUM
gs-3799	568	4	,	,	PUNCT
gs-3799	568	5	2025	2025	NUM
gs-3799	568	6	408	408	NUM
gs-3799	568	7	engines	engine	NOUN
gs-3799	568	8	,	,	PUNCT
gs-3799	568	9	digital	digital	ADJ
gs-3799	568	10	twins	twin	NOUN
gs-3799	568	11	are	be	AUX
gs-3799	568	12	co	co	ADJ
gs-3799	568	13	-	-	ADJ
gs-3799	568	14	evolving	evolve	VERB
gs-3799	568	15	entities	entity	NOUN
gs-3799	568	16	,	,	PUNCT
gs-3799	568	17	recalibrating	recalibrate	VERB
gs-3799	568	18	with	with	ADP
gs-3799	568	19	each	each	DET
gs-3799	568	20	pulse	pulse	NOUN
gs-3799	568	21	of	of	ADP
gs-3799	568	22	real	real	ADJ
gs-3799	568	23	-	-	PUNCT
gs-3799	568	24	time	time	NOUN
gs-3799	568	25	data	datum	NOUN
gs-3799	568	26	.	.	PUNCT
gs-3799	569	1	within	within	ADP
gs-3799	569	2	cl	cl	NOUN
gs-3799	569	3	-	-	PUNCT
gs-3799	569	4	cpb	cpb	NOUN
gs-3799	569	5	,	,	PUNCT
gs-3799	569	6	they	they	PRON
gs-3799	569	7	are	be	AUX
gs-3799	569	8	now	now	ADV
gs-3799	569	9	being	be	AUX
gs-3799	569	10	used	use	VERB
gs-3799	569	11	to	to	PART
gs-3799	569	12	test	test	VERB
gs-3799	569	13	pharmacologic	pharmacologic	ADJ
gs-3799	569	14	infusions	infusion	NOUN
gs-3799	569	15	,	,	PUNCT
gs-3799	569	16	pump	pump	VERB
gs-3799	569	17	speed	speed	NOUN
gs-3799	569	18	changes	change	NOUN
gs-3799	569	19	,	,	PUNCT
gs-3799	569	20	oxygenator	oxygenator	NOUN
gs-3799	569	21	adjustments	adjustment	NOUN
gs-3799	569	22	,	,	PUNCT
gs-3799	569	23	and	and	CCONJ
gs-3799	569	24	systemic	systemic	ADJ
gs-3799	569	25	rewarming	rewarming	NOUN
gs-3799	569	26	strategies	strategy	NOUN
gs-3799	569	27	prior	prior	ADV
gs-3799	569	28	to	to	ADP
gs-3799	569	29	actual	actual	ADJ
gs-3799	569	30	deployment	deployment	NOUN
gs-3799	569	31	.	.	PUNCT
gs-3799	570	1	results	result	NOUN
gs-3799	570	2	from	from	ADP
gs-3799	570	3	pilot	pilot	NOUN
gs-3799	570	4	programs	program	NOUN
gs-3799	570	5	integrating	integrate	VERB
gs-3799	570	6	digital	digital	ADJ
gs-3799	570	7	twins	twin	NOUN
gs-3799	570	8	with	with	ADP
gs-3799	570	9	bypass	bypass	NOUN
gs-3799	570	10	control	control	NOUN
gs-3799	570	11	have	have	AUX
gs-3799	570	12	shown	show	VERB
gs-3799	570	13	early	early	ADJ
gs-3799	570	14	reductions	reduction	NOUN
gs-3799	570	15	in	in	ADP
gs-3799	570	16	intraoperative	intraoperative	ADJ
gs-3799	570	17	lactate	lactate	NOUN
gs-3799	570	18	levels	level	NOUN
gs-3799	570	19	,	,	PUNCT
gs-3799	570	20	less	less	ADV
gs-3799	570	21	frequent	frequent	ADJ
gs-3799	570	22	arrhythmogenic	arrhythmogenic	ADJ
gs-3799	570	23	episodes	episode	NOUN
gs-3799	570	24	,	,	PUNCT
gs-3799	570	25	and	and	CCONJ
gs-3799	570	26	more	more	ADV
gs-3799	570	27	stable	stable	ADJ
gs-3799	570	28	glycemic	glycemic	ADJ
gs-3799	570	29	control	control	NOUN
gs-3799	570	30	.	.	PUNCT
gs-3799	571	1	these	these	DET
gs-3799	571	2	findings	finding	NOUN
gs-3799	571	3	reinforce	reinforce	VERB
gs-3799	571	4	the	the	DET
gs-3799	571	5	notion	notion	NOUN
gs-3799	571	6	that	that	SCONJ
gs-3799	571	7	anticipatory	anticipatory	ADJ
gs-3799	571	8	computation	computation	NOUN
gs-3799	571	9	may	may	AUX
gs-3799	571	10	be	be	AUX
gs-3799	571	11	key	key	ADJ
gs-3799	571	12	to	to	ADP
gs-3799	571	13	optimizing	optimize	VERB
gs-3799	571	14	biologically	biologically	ADV
gs-3799	571	15	fragile	fragile	ADJ
gs-3799	571	16	transitions	transition	NOUN
gs-3799	571	17	,	,	PUNCT
gs-3799	571	18	such	such	ADJ
gs-3799	571	19	as	as	ADP
gs-3799	571	20	weaning	wean	VERB
gs-3799	571	21	from	from	ADP
gs-3799	571	22	bypass	bypass	NOUN
gs-3799	571	23	or	or	CCONJ
gs-3799	571	24	managing	manage	VERB
gs-3799	571	25	inflammatory	inflammatory	ADJ
gs-3799	571	26	rebound	rebound	VERB
gs-3799	571	27	post	post	ADJ
gs-3799	571	28	-	-	ADJ
gs-3799	571	29	cross	cross	ADJ
gs-3799	571	30	-	-	ADJ
gs-3799	571	31	clamp	clamp	ADJ
gs-3799	571	32	removal	removal	NOUN
gs-3799	571	33	.	.	PUNCT
gs-3799	572	1	neuroimmunological	neuroimmunological	ADJ
gs-3799	572	2	feedback	feedback	NOUN
gs-3799	572	3	loops	loop	NOUN
gs-3799	572	4	in	in	ADP
gs-3799	572	5	autonomous	autonomous	ADJ
gs-3799	572	6	cpb	cpb	PROPN
gs-3799	572	7	systems	system	NOUN
gs-3799	572	8	:	:	PUNCT
gs-3799	572	9	the	the	DET
gs-3799	572	10	brain	brain	NOUN
gs-3799	572	11	-	-	PUNCT
gs-3799	572	12	immune	immune	ADJ
gs-3799	572	13	interface	interface	NOUN
gs-3799	572	14	,	,	PUNCT
gs-3799	572	15	long	long	ADV
gs-3799	572	16	underestimated	underestimate	VERB
gs-3799	572	17	in	in	ADP
gs-3799	572	18	surgical	surgical	ADJ
gs-3799	572	19	physiology	physiology	NOUN
gs-3799	572	20	,	,	PUNCT
gs-3799	572	21	is	be	AUX
gs-3799	572	22	now	now	ADV
gs-3799	572	23	central	central	ADJ
gs-3799	572	24	to	to	ADP
gs-3799	572	25	advanced	advanced	ADJ
gs-3799	572	26	cl	cl	NOUN
gs-3799	572	27	-	-	PUNCT
gs-3799	572	28	cpb	cpb	NOUN
gs-3799	572	29	logic	logic	NOUN
gs-3799	572	30	.	.	PUNCT
gs-3799	573	1	bypass	bypass	NOUN
gs-3799	573	2	triggers	trigger	VERB
gs-3799	573	3	a	a	DET
gs-3799	573	4	cascade	cascade	NOUN
gs-3799	573	5	of	of	ADP
gs-3799	573	6	neuroimmunological	neuroimmunological	ADJ
gs-3799	573	7	responses	response	NOUN
gs-3799	573	8	,	,	PUNCT
gs-3799	573	9	from	from	ADP
gs-3799	573	10	hypothalamic	hypothalamic	ADJ
gs-3799	573	11	-	-	PUNCT
gs-3799	573	12	pituitary	pituitary	ADJ
gs-3799	573	13	-	-	PUNCT
gs-3799	573	14	adrenal	adrenal	ADJ
gs-3799	573	15	axis	axis	NOUN
gs-3799	573	16	activation	activation	NOUN
gs-3799	573	17	to	to	ADP
gs-3799	573	18	sympathetic	sympathetic	ADJ
gs-3799	573	19	-	-	PUNCT
gs-3799	573	20	mediated	mediate	VERB
gs-3799	573	21	modulation	modulation	NOUN
gs-3799	573	22	of	of	ADP
gs-3799	573	23	leukocyte	leukocyte	NOUN
gs-3799	573	24	trafficking	trafficking	NOUN
gs-3799	573	25	.	.	PUNCT
gs-3799	574	1	new	new	ADJ
gs-3799	574	2	cl	cl	NOUN
gs-3799	574	3	-	-	PUNCT
gs-3799	574	4	cpb	cpb	NOUN
gs-3799	574	5	designs	design	NOUN
gs-3799	574	6	now	now	ADV
gs-3799	574	7	incorporate	incorporate	VERB
gs-3799	574	8	real	real	ADJ
gs-3799	574	9	-	-	PUNCT
gs-3799	574	10	time	time	NOUN
gs-3799	574	11	biomarkers	biomarker	NOUN
gs-3799	574	12	of	of	ADP
gs-3799	574	13	both	both	CCONJ
gs-3799	574	14	neural	neural	ADJ
gs-3799	574	15	and	and	CCONJ
gs-3799	574	16	immune	immune	ADJ
gs-3799	574	17	activity	activity	NOUN
gs-3799	574	18	,	,	PUNCT
gs-3799	574	19	including	include	VERB
gs-3799	574	20	heart	heart	NOUN
gs-3799	574	21	rate	rate	NOUN
gs-3799	574	22	variability	variability	NOUN
gs-3799	574	23	(	(	PUNCT
gs-3799	574	24	as	as	ADP
gs-3799	574	25	a	a	DET
gs-3799	574	26	surrogate	surrogate	NOUN
gs-3799	574	27	of	of	ADP
gs-3799	574	28	vagal	vagal	ADJ
gs-3799	574	29	tone	tone	NOUN
gs-3799	574	30	)	)	PUNCT
gs-3799	574	31	,	,	PUNCT
gs-3799	574	32	serum	serum	NOUN
gs-3799	574	33	cortisol	cortisol	ADJ
gs-3799	574	34	gradients	gradient	NOUN
gs-3799	574	35	,	,	PUNCT
gs-3799	574	36	and	and	CCONJ
gs-3799	574	37	peripheral	peripheral	ADJ
gs-3799	574	38	leukocyte	leukocyte	NOUN
gs-3799	574	39	transcriptomics	transcriptomic	NOUN
gs-3799	574	40	.	.	PUNCT
gs-3799	575	1	closed	close	VERB
gs-3799	575	2	-	-	PUNCT
gs-3799	575	3	loop	loop	NOUN
gs-3799	575	4	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	575	5	agents	agent	NOUN
gs-3799	575	6	—	—	PUNCT
gs-3799	575	7	such	such	ADJ
gs-3799	575	8	as	as	ADP
gs-3799	575	9	dexmedetomidine	dexmedetomidine	ADJ
gs-3799	575	10	or	or	CCONJ
gs-3799	575	11	norepinephrine	norepinephrine	NOUN
gs-3799	575	12	—	—	PUNCT
gs-3799	575	13	are	be	AUX
gs-3799	575	14	dynamically	dynamically	ADV
gs-3799	575	15	titrated	titrate	VERB
gs-3799	575	16	not	not	PART
gs-3799	575	17	only	only	ADV
gs-3799	575	18	to	to	PART
gs-3799	575	19	map	map	VERB
gs-3799	575	20	or	or	CCONJ
gs-3799	575	21	bis	bis	ADJ
gs-3799	575	22	index	index	NOUN
gs-3799	575	23	but	but	CCONJ
gs-3799	575	24	also	also	ADV
gs-3799	575	25	to	to	ADP
gs-3799	575	26	composite	composite	ADJ
gs-3799	575	27	neuroimmune	neuroimmune	NOUN
gs-3799	575	28	stress	stress	NOUN
gs-3799	575	29	indices	index	NOUN
gs-3799	575	30	.	.	PUNCT
gs-3799	576	1	systems	system	NOUN
gs-3799	576	2	utilizing	utilize	VERB
gs-3799	576	3	such	such	ADJ
gs-3799	576	4	indices	index	NOUN
gs-3799	576	5	have	have	AUX
gs-3799	576	6	demonstrated	demonstrate	VERB
gs-3799	576	7	superior	superior	ADJ
gs-3799	576	8	organ	organ	NOUN
gs-3799	576	9	preservation	preservation	NOUN
gs-3799	576	10	,	,	PUNCT
gs-3799	576	11	reduced	reduce	VERB
gs-3799	576	12	proinflammatory	proinflammatory	ADJ
gs-3799	576	13	cytokine	cytokine	NOUN
gs-3799	576	14	levels	level	NOUN
gs-3799	576	15	at	at	ADP
gs-3799	576	16	12	12	NUM
gs-3799	576	17	hours	hour	NOUN
gs-3799	576	18	post	post	ADJ
gs-3799	576	19	-	-	NOUN
gs-3799	576	20	bypass	bypass	NOUN
gs-3799	576	21	,	,	PUNCT
gs-3799	576	22	and	and	CCONJ
gs-3799	576	23	shorter	short	ADJ
gs-3799	576	24	extubation	extubation	NOUN
gs-3799	576	25	times	time	NOUN
gs-3799	576	26	.	.	PUNCT
gs-3799	577	1	this	this	DET
gs-3799	577	2	axis	axis	NOUN
gs-3799	577	3	represents	represent	VERB
gs-3799	577	4	a	a	DET
gs-3799	577	5	breakthrough	breakthrough	NOUN
gs-3799	577	6	in	in	ADP
gs-3799	577	7	perioperative	perioperative	ADJ
gs-3799	577	8	precision	precision	NOUN
gs-3799	577	9	medicine	medicine	NOUN
gs-3799	577	10	:	:	PUNCT
gs-3799	577	11	not	not	PART
gs-3799	577	12	merely	merely	ADV
gs-3799	577	13	controlling	control	VERB
gs-3799	577	14	physiology	physiology	NOUN
gs-3799	577	15	,	,	PUNCT
gs-3799	577	16	but	but	CCONJ
gs-3799	577	17	regulating	regulate	VERB
gs-3799	577	18	systems	system	NOUN
gs-3799	577	19	-	-	PUNCT
gs-3799	577	20	level	level	NOUN
gs-3799	577	21	inflammatory	inflammatory	ADJ
gs-3799	577	22	coherence	coherence	NOUN
gs-3799	577	23	.	.	PUNCT
gs-3799	578	1	intelligent	intelligent	ADJ
gs-3799	578	2	agents	agent	NOUN
gs-3799	578	3	and	and	CCONJ
gs-3799	578	4	cooperative	cooperative	ADJ
gs-3799	578	5	learning	learning	NOUN
gs-3799	578	6	in	in	ADP
gs-3799	578	7	surgical	surgical	ADJ
gs-3799	578	8	cognition	cognition	NOUN
gs-3799	578	9	:	:	PUNCT
gs-3799	578	10	modern	modern	ADJ
gs-3799	578	11	cl	cl	NOUN
gs-3799	578	12	-	-	PUNCT
gs-3799	578	13	cpb	cpb	NOUN
gs-3799	578	14	platforms	platform	NOUN
gs-3799	578	15	are	be	AUX
gs-3799	578	16	now	now	ADV
gs-3799	578	17	populated	populate	VERB
gs-3799	578	18	with	with	ADP
gs-3799	578	19	cooperative	cooperative	ADJ
gs-3799	578	20	ai	ai	PROPN
gs-3799	578	21	agents	agent	NOUN
gs-3799	578	22	,	,	PUNCT
gs-3799	578	23	each	each	PRON
gs-3799	578	24	responsible	responsible	ADJ
gs-3799	578	25	for	for	ADP
gs-3799	578	26	discrete	discrete	ADJ
gs-3799	578	27	functions	function	NOUN
gs-3799	578	28	—	—	PUNCT
gs-3799	578	29	oxygenation	oxygenation	NOUN
gs-3799	578	30	,	,	PUNCT
gs-3799	578	31	hemodynamic	hemodynamic	ADJ
gs-3799	578	32	equilibrium	equilibrium	NOUN
gs-3799	578	33	,	,	PUNCT
gs-3799	578	34	renal	renal	ADJ
gs-3799	578	35	perfusion	perfusion	NOUN
gs-3799	578	36	,	,	PUNCT
gs-3799	578	37	cerebral	cerebral	ADJ
gs-3799	578	38	autoregulation	autoregulation	NOUN
gs-3799	578	39	—	—	PUNCT
gs-3799	578	40	but	but	CCONJ
gs-3799	578	41	operating	operate	VERB
gs-3799	578	42	in	in	ADP
gs-3799	578	43	communicative	communicative	ADJ
gs-3799	578	44	synergy	synergy	NOUN
gs-3799	578	45	.	.	PUNCT
gs-3799	579	1	these	these	DET
gs-3799	579	2	agents	agent	NOUN
gs-3799	579	3	utilize	utilize	VERB
gs-3799	579	4	shared	share	VERB
gs-3799	579	5	reinforcement	reinforcement	NOUN
gs-3799	579	6	learning	learning	NOUN
gs-3799	579	7	environments	environment	NOUN
gs-3799	579	8	,	,	PUNCT
gs-3799	579	9	meaning	mean	VERB
gs-3799	579	10	that	that	SCONJ
gs-3799	579	11	feedback	feedback	NOUN
gs-3799	579	12	received	receive	VERB
gs-3799	579	13	by	by	ADP
gs-3799	579	14	one	one	NUM
gs-3799	579	15	agent	agent	NOUN
gs-3799	579	16	(	(	PUNCT
gs-3799	579	17	e.g.	e.g.	ADV
gs-3799	579	18	,	,	PUNCT
gs-3799	579	19	improved	improve	VERB
gs-3799	579	20	cerebral	cerebral	ADJ
gs-3799	579	21	perfusion	perfusion	NOUN
gs-3799	579	22	)	)	PUNCT
gs-3799	579	23	updates	update	VERB
gs-3799	579	24	the	the	DET
gs-3799	579	25	reward	reward	NOUN
gs-3799	579	26	models	model	NOUN
gs-3799	579	27	of	of	ADP
gs-3799	579	28	other	other	ADJ
gs-3799	579	29	agents	agent	NOUN
gs-3799	579	30	(	(	PUNCT
gs-3799	579	31	e.g.	e.g.	ADV
gs-3799	579	32	,	,	PUNCT
gs-3799	579	33	vasopressor	vasopressor	NOUN
gs-3799	579	34	modulation	modulation	NOUN
gs-3799	579	35	)	)	PUNCT
gs-3799	579	36	.	.	PUNCT
gs-3799	580	1	this	this	DET
gs-3799	580	2	inter	inter	ADJ
gs-3799	580	3	-	-	ADJ
gs-3799	580	4	agent	agent	ADJ
gs-3799	580	5	communication	communication	NOUN
gs-3799	580	6	enables	enable	VERB
gs-3799	580	7	emergent	emergent	ADJ
gs-3799	580	8	decision	decision	NOUN
gs-3799	580	9	-	-	PUNCT
gs-3799	580	10	making	making	NOUN
gs-3799	580	11	beyond	beyond	ADP
gs-3799	580	12	human	human	ADJ
gs-3799	580	13	anticipation	anticipation	NOUN
gs-3799	580	14	and	and	CCONJ
gs-3799	580	15	surpasses	surpass	VERB
gs-3799	580	16	any	any	DET
gs-3799	580	17	single	single	ADJ
gs-3799	580	18	-	-	PUNCT
gs-3799	580	19	variable	variable	ADJ
gs-3799	580	20	optimization	optimization	NOUN
gs-3799	580	21	paradigm	paradigm	NOUN
gs-3799	580	22	.	.	PUNCT
gs-3799	581	1	in	in	ADP
gs-3799	581	2	recent	recent	ADJ
gs-3799	581	3	operating	operating	NOUN
gs-3799	581	4	suite	suite	NOUN
gs-3799	581	5	deployments	deployment	NOUN
gs-3799	581	6	,	,	PUNCT
gs-3799	581	7	teams	team	NOUN
gs-3799	581	8	reported	report	VERB
gs-3799	581	9	a	a	DET
gs-3799	581	10	marked	mark	VERB
gs-3799	581	11	shift	shift	NOUN
gs-3799	581	12	in	in	ADP
gs-3799	581	13	cognitive	cognitive	ADJ
gs-3799	581	14	workflow	workflow	NOUN
gs-3799	581	15	:	:	PUNCT
gs-3799	581	16	surgeons	surgeon	NOUN
gs-3799	581	17	and	and	CCONJ
gs-3799	581	18	anesthesiologists	anesthesiologist	NOUN
gs-3799	581	19	transitioned	transition	VERB
gs-3799	581	20	from	from	ADP
gs-3799	581	21	direct	direct	ADJ
gs-3799	581	22	control	control	NOUN
gs-3799	581	23	to	to	ADP
gs-3799	581	24	strategic	strategic	ADJ
gs-3799	581	25	oversight	oversight	NOUN
gs-3799	581	26	,	,	PUNCT
gs-3799	581	27	trusting	trust	VERB
gs-3799	581	28	multi	multi	ADJ
gs-3799	581	29	-	-	ADJ
gs-3799	581	30	agent	agent	ADJ
gs-3799	581	31	consensus	consensus	NOUN
gs-3799	581	32	decisions	decision	NOUN
gs-3799	581	33	while	while	SCONJ
gs-3799	581	34	focusing	focus	VERB
gs-3799	581	35	on	on	ADP
gs-3799	581	36	procedural	procedural	ADJ
gs-3799	581	37	navigation	navigation	NOUN
gs-3799	581	38	.	.	PUNCT
gs-3799	582	1	this	this	DET
gs-3799	582	2	evolution	evolution	NOUN
gs-3799	582	3	not	not	PART
gs-3799	582	4	only	only	ADV
gs-3799	582	5	reduced	reduce	VERB
gs-3799	582	6	cognitive	cognitive	ADJ
gs-3799	582	7	fatigue	fatigue	NOUN
gs-3799	582	8	but	but	CCONJ
gs-3799	582	9	also	also	ADV
gs-3799	582	10	supported	support	VERB
gs-3799	582	11	faster	fast	ADV
gs-3799	582	12	intraoperative	intraoperative	ADJ
gs-3799	582	13	adaptation	adaptation	NOUN
gs-3799	582	14	to	to	ADP
gs-3799	582	15	complications	complication	NOUN
gs-3799	582	16	like	like	ADP
gs-3799	582	17	air	air	NOUN
gs-3799	582	18	embolism	embolism	NOUN
gs-3799	582	19	or	or	CCONJ
gs-3799	582	20	protamine	protamine	NOUN
gs-3799	582	21	hypersensitivity	hypersensitivity	NOUN
gs-3799	582	22	.	.	PUNCT
gs-3799	583	1	high	high	ADJ
gs-3799	583	2	-	-	PUNCT
gs-3799	583	3	throughput	throughput	NOUN
gs-3799	583	4	perfusionomics	perfusionomic	NOUN
gs-3799	583	5	and	and	CCONJ
gs-3799	583	6	multi	multi	ADJ
gs-3799	583	7	-	-	ADJ
gs-3799	583	8	omic	omic	ADJ
gs-3799	583	9	integration	integration	NOUN
gs-3799	583	10	:	:	PUNCT
gs-3799	583	11	the	the	DET
gs-3799	583	12	field	field	NOUN
gs-3799	583	13	of	of	ADP
gs-3799	583	14	perfusionomics	perfusionomic	NOUN
gs-3799	583	15	—	—	PUNCT
gs-3799	583	16	the	the	DET
gs-3799	583	17	high	high	ADJ
gs-3799	583	18	-	-	PUNCT
gs-3799	583	19	throughput	throughput	NOUN
gs-3799	583	20	analysis	analysis	NOUN
gs-3799	583	21	of	of	ADP
gs-3799	583	22	perfusion	perfusion	NOUN
gs-3799	583	23	-	-	PUNCT
gs-3799	583	24	related	relate	VERB
gs-3799	583	25	molecular	molecular	ADJ
gs-3799	583	26	,	,	PUNCT
gs-3799	583	27	metabolic	metabolic	NOUN
gs-3799	583	28	,	,	PUNCT
gs-3799	583	29	and	and	CCONJ
gs-3799	583	30	electrophysiological	electrophysiological	ADJ
gs-3799	583	31	data	datum	NOUN
gs-3799	583	32	—	—	PUNCT
gs-3799	583	33	is	be	AUX
gs-3799	583	34	becoming	become	VERB
gs-3799	583	35	a	a	DET
gs-3799	583	36	defining	define	VERB
gs-3799	583	37	feature	feature	NOUN
gs-3799	583	38	of	of	ADP
gs-3799	583	39	ultra	ultra	ADJ
gs-3799	583	40	-	-	ADJ
gs-3799	583	41	modern	modern	ADJ
gs-3799	583	42	closed	closed	ADJ
gs-3799	583	43	-	-	PUNCT
gs-3799	583	44	loop	loop	NOUN
gs-3799	583	45	systems	system	NOUN
gs-3799	583	46	.	.	PUNCT
gs-3799	584	1	real	real	ADJ
gs-3799	584	2	-	-	PUNCT
gs-3799	584	3	time	time	NOUN
gs-3799	584	4	mass	mass	PROPN
gs-3799	584	5	spectrometry	spectrometry	NOUN
gs-3799	584	6	and	and	CCONJ
gs-3799	584	7	biochip	biochip	NOUN
gs-3799	584	8	analytics	analytic	NOUN
gs-3799	584	9	now	now	ADV
gs-3799	584	10	enable	enable	VERB
gs-3799	584	11	simultaneous	simultaneous	ADJ
gs-3799	584	12	monitoring	monitoring	NOUN
gs-3799	584	13	of	of	ADP
gs-3799	584	14	hundreds	hundred	NOUN
gs-3799	584	15	of	of	ADP
gs-3799	584	16	metabolites	metabolite	NOUN
gs-3799	584	17	and	and	CCONJ
gs-3799	584	18	proteins	protein	NOUN
gs-3799	584	19	during	during	ADP
gs-3799	584	20	bypass	bypass	NOUN
gs-3799	584	21	.	.	PUNCT
gs-3799	585	1	closed	close	VERB
gs-3799	585	2	-	-	PUNCT
gs-3799	585	3	loop	loop	NOUN
gs-3799	585	4	systems	system	NOUN
gs-3799	585	5	incorporate	incorporate	VERB
gs-3799	585	6	this	this	DET
gs-3799	585	7	data	datum	NOUN
gs-3799	585	8	to	to	PART
gs-3799	585	9	assess	assess	VERB
gs-3799	585	10	metabolic	metabolic	NOUN
gs-3799	585	11	sufficiency	sufficiency	NOUN
gs-3799	585	12	,	,	PUNCT
gs-3799	585	13	identify	identify	VERB
gs-3799	585	14	early	early	ADJ
gs-3799	585	15	signs	sign	NOUN
gs-3799	585	16	of	of	ADP
gs-3799	585	17	mitochondrial	mitochondrial	ADJ
gs-3799	585	18	distress	distress	NOUN
gs-3799	585	19	,	,	PUNCT
gs-3799	585	20	and	and	CCONJ
gs-3799	585	21	titrate	titrate	NOUN
gs-3799	585	22	metabolic	metabolic	NOUN
gs-3799	585	23	substrates	substrate	NOUN
gs-3799	585	24	such	such	ADJ
gs-3799	585	25	as	as	ADP
gs-3799	585	26	pyruvate	pyruvate	NOUN
gs-3799	585	27	or	or	CCONJ
gs-3799	585	28	ketone	ketone	NOUN
gs-3799	585	29	bodies	body	NOUN
gs-3799	585	30	to	to	PART
gs-3799	585	31	optimize	optimize	VERB
gs-3799	585	32	tissue	tissue	NOUN
gs-3799	585	33	-	-	PUNCT
gs-3799	585	34	level	level	NOUN
gs-3799	585	35	energetics	energetic	NOUN
gs-3799	585	36	.	.	PUNCT
gs-3799	586	1	in	in	ADP
gs-3799	586	2	systems	system	NOUN
gs-3799	586	3	utilizing	utilize	VERB
gs-3799	586	4	multi	multi	ADJ
gs-3799	586	5	-	-	ADJ
gs-3799	586	6	omic	omic	ADJ
gs-3799	586	7	feedback	feedback	NOUN
gs-3799	586	8	integration	integration	NOUN
gs-3799	586	9	—	—	PUNCT
gs-3799	586	10	combining	combine	VERB
gs-3799	586	11	genomics	genomics	NOUN
gs-3799	586	12	,	,	PUNCT
gs-3799	586	13	transcriptomics	transcriptomic	NOUN
gs-3799	586	14	,	,	PUNCT
gs-3799	586	15	proteomics	proteomic	NOUN
gs-3799	586	16	,	,	PUNCT
gs-3799	586	17	and	and	CCONJ
gs-3799	586	18	metabolomics	metabolomic	NOUN
gs-3799	586	19	—	—	PUNCT
gs-3799	586	20	the	the	DET
gs-3799	586	21	pharmacological	pharmacological	ADJ
gs-3799	586	22	loop	loop	NOUN
gs-3799	586	23	is	be	AUX
gs-3799	586	24	no	no	ADV
gs-3799	586	25	longer	long	ADV
gs-3799	586	26	fixed	fix	VERB
gs-3799	586	27	but	but	CCONJ
gs-3799	586	28	adaptive	adaptive	ADJ
gs-3799	586	29	.	.	PUNCT
gs-3799	587	1	for	for	ADP
gs-3799	587	2	instance	instance	NOUN
gs-3799	587	3	,	,	PUNCT
gs-3799	587	4	polymorphisms	polymorphism	NOUN
gs-3799	587	5	in	in	ADP
gs-3799	587	6	-adrenergic	-adrenergic	ADJ
gs-3799	587	7	georgian	georgian	NOUN
gs-3799	587	8	scientists/	scientists/	NUM
gs-3799	587	9	.	.	PUNCT
gs-3799	588	1	7	7	NUM
gs-3799	588	2	n	n	DET
gs-3799	588	3	2	2	NUM
gs-3799	588	4	,	,	PUNCT
gs-3799	588	5	2025	2025	NUM
gs-3799	588	6	409	409	NUM
gs-3799	588	7	receptor	receptor	NOUN
gs-3799	588	8	genes	gene	NOUN
gs-3799	588	9	influence	influence	VERB
gs-3799	588	10	norepinephrine	norepinephrine	NOUN
gs-3799	588	11	dosing	dose	VERB
gs-3799	588	12	during	during	ADP
gs-3799	588	13	vasoplegic	vasoplegic	NOUN
gs-3799	588	14	episodes	episode	NOUN
gs-3799	588	15	.	.	PUNCT
gs-3799	589	1	such	such	ADJ
gs-3799	589	2	platforms	platform	NOUN
gs-3799	589	3	provide	provide	VERB
gs-3799	589	4	real	real	ADJ
gs-3799	589	5	-	-	PUNCT
gs-3799	589	6	time	time	NOUN
gs-3799	589	7	adjustment	adjustment	NOUN
gs-3799	589	8	to	to	ADP
gs-3799	589	9	infusion	infusion	NOUN
gs-3799	589	10	protocols	protocol	NOUN
gs-3799	589	11	that	that	PRON
gs-3799	589	12	are	be	AUX
gs-3799	589	13	both	both	PRON
gs-3799	589	14	genotype	genotype	NOUN
gs-3799	589	15	-	-	PUNCT
gs-3799	589	16	aware	aware	ADJ
gs-3799	589	17	and	and	CCONJ
gs-3799	589	18	phenotype	phenotype	NOUN
gs-3799	589	19	-	-	PUNCT
gs-3799	589	20	verified	verify	VERB
gs-3799	589	21	.	.	PUNCT
gs-3799	590	1	multi	multi	ADJ
gs-3799	590	2	-	-	ADJ
gs-3799	590	3	layered	layered	ADJ
gs-3799	590	4	safety	safety	NOUN
gs-3799	590	5	mechanisms	mechanism	NOUN
gs-3799	590	6	and	and	CCONJ
gs-3799	590	7	fail	fail	ADJ
gs-3799	590	8	-	-	PUNCT
gs-3799	590	9	safe	safe	ADJ
gs-3799	590	10	logic	logic	NOUN
gs-3799	590	11	:	:	PUNCT
gs-3799	590	12	the	the	DET
gs-3799	590	13	evolution	evolution	NOUN
gs-3799	590	14	of	of	ADP
gs-3799	590	15	fully	fully	ADV
gs-3799	590	16	autonomous	autonomous	ADJ
gs-3799	590	17	systems	system	NOUN
gs-3799	590	18	necessitates	necessitate	VERB
gs-3799	590	19	new	new	ADJ
gs-3799	590	20	tiers	tier	NOUN
gs-3799	590	21	of	of	ADP
gs-3799	590	22	embedded	embed	VERB
gs-3799	590	23	safety	safety	NOUN
gs-3799	590	24	.	.	PUNCT
gs-3799	591	1	current	current	ADJ
gs-3799	591	2	models	model	NOUN
gs-3799	591	3	integrate	integrate	VERB
gs-3799	591	4	multi	multi	ADJ
gs-3799	591	5	-	-	ADJ
gs-3799	591	6	layered	layered	ADJ
gs-3799	591	7	defense	defense	NOUN
gs-3799	591	8	architectures	architecture	NOUN
gs-3799	591	9	,	,	PUNCT
gs-3799	591	10	including	include	VERB
gs-3799	591	11	predictive	predictive	ADJ
gs-3799	591	12	signal	signal	NOUN
gs-3799	591	13	anomaly	anomaly	NOUN
gs-3799	591	14	detectors	detector	NOUN
gs-3799	591	15	,	,	PUNCT
gs-3799	591	16	mechanical	mechanical	ADJ
gs-3799	591	17	redundancy	redundancy	NOUN
gs-3799	591	18	with	with	ADP
gs-3799	591	19	dual	dual	ADJ
gs-3799	591	20	-	-	PUNCT
gs-3799	591	21	pump	pump	NOUN
gs-3799	591	22	fallback	fallback	NOUN
gs-3799	591	23	,	,	PUNCT
gs-3799	591	24	and	and	CCONJ
gs-3799	591	25	supervisory	supervisory	ADJ
gs-3799	591	26	human	human	NOUN
gs-3799	591	27	-	-	PUNCT
gs-3799	591	28	in	in	ADP
gs-3799	591	29	-	-	PUNCT
gs-3799	591	30	the	the	DET
gs-3799	591	31	-	-	PUNCT
gs-3799	591	32	loop	loop	NOUN
gs-3799	591	33	alarms	alarm	NOUN
gs-3799	591	34	that	that	PRON
gs-3799	591	35	require	require	VERB
gs-3799	591	36	verbal	verbal	ADJ
gs-3799	591	37	confirmation	confirmation	NOUN
gs-3799	591	38	to	to	PART
gs-3799	591	39	override	override	VERB
gs-3799	591	40	default	default	NOUN
gs-3799	591	41	automation	automation	NOUN
gs-3799	591	42	.	.	PUNCT
gs-3799	592	1	in	in	ADP
gs-3799	592	2	high	high	ADJ
gs-3799	592	3	-	-	PUNCT
gs-3799	592	4	risk	risk	NOUN
gs-3799	592	5	surgeries	surgery	NOUN
gs-3799	592	6	such	such	ADJ
gs-3799	592	7	as	as	ADP
gs-3799	592	8	aortic	aortic	ADJ
gs-3799	592	9	arch	arch	ADJ
gs-3799	592	10	reconstructions	reconstruction	NOUN
gs-3799	592	11	or	or	CCONJ
gs-3799	592	12	redo	redo	NOUN
gs-3799	592	13	sternotomies	sternotomie	NOUN
gs-3799	592	14	,	,	PUNCT
gs-3799	592	15	these	these	DET
gs-3799	592	16	safety	safety	NOUN
gs-3799	592	17	architectures	architecture	NOUN
gs-3799	592	18	have	have	AUX
gs-3799	592	19	shown	show	VERB
gs-3799	592	20	an	an	DET
gs-3799	592	21	83	83	NUM
gs-3799	592	22	%	%	NOUN
gs-3799	592	23	reduction	reduction	NOUN
gs-3799	592	24	in	in	ADP
gs-3799	592	25	serious	serious	ADJ
gs-3799	592	26	intraoperative	intraoperative	ADJ
gs-3799	592	27	errors	error	NOUN
gs-3799	592	28	over	over	ADP
gs-3799	592	29	legacy	legacy	NOUN
gs-3799	592	30	semi	semi	ADJ
gs-3799	592	31	-	-	ADJ
gs-3799	592	32	automated	automated	ADJ
gs-3799	592	33	cpb	cpb	NOUN
gs-3799	592	34	systems	system	NOUN
gs-3799	592	35	.	.	PUNCT
gs-3799	593	1	furthermore	furthermore	ADV
gs-3799	593	2	,	,	PUNCT
gs-3799	593	3	the	the	DET
gs-3799	593	4	inclusion	inclusion	NOUN
gs-3799	593	5	of	of	ADP
gs-3799	593	6	formal	formal	ADJ
gs-3799	593	7	verification	verification	NOUN
gs-3799	593	8	protocols	protocol	NOUN
gs-3799	593	9	,	,	PUNCT
gs-3799	593	10	derived	derive	VERB
gs-3799	593	11	from	from	ADP
gs-3799	593	12	software	software	NOUN
gs-3799	593	13	reliability	reliability	NOUN
gs-3799	593	14	engineering	engineering	NOUN
gs-3799	593	15	,	,	PUNCT
gs-3799	593	16	ensures	ensure	VERB
gs-3799	593	17	that	that	SCONJ
gs-3799	593	18	algorithmic	algorithmic	ADJ
gs-3799	593	19	decision	decision	NOUN
gs-3799	593	20	paths	path	NOUN
gs-3799	593	21	conform	conform	VERB
gs-3799	593	22	to	to	ADP
gs-3799	593	23	mathematically	mathematically	ADV
gs-3799	593	24	validated	validate	VERB
gs-3799	593	25	safety	safety	NOUN
gs-3799	593	26	sets	set	NOUN
gs-3799	593	27	.	.	PUNCT
gs-3799	594	1	closing	close	VERB
gs-3799	594	2	reflection	reflection	NOUN
gs-3799	594	3	:	:	PUNCT
gs-3799	594	4	this	this	DET
gs-3799	594	5	expanded	expand	VERB
gs-3799	594	6	results	result	NOUN
gs-3799	594	7	&	&	CCONJ
gs-3799	594	8	discussion	discussion	NOUN
gs-3799	594	9	substantiates	substantiate	VERB
gs-3799	594	10	that	that	SCONJ
gs-3799	594	11	the	the	DET
gs-3799	594	12	frontier	frontier	NOUN
gs-3799	594	13	of	of	ADP
gs-3799	594	14	closedloop	closedloop	PROPN
gs-3799	594	15	cpb	cpb	PROPN
gs-3799	594	16	is	be	AUX
gs-3799	594	17	no	no	ADV
gs-3799	594	18	longer	long	ADV
gs-3799	594	19	defined	define	VERB
gs-3799	594	20	by	by	ADP
gs-3799	594	21	hardware	hardware	NOUN
gs-3799	594	22	fidelity	fidelity	NOUN
gs-3799	594	23	or	or	CCONJ
gs-3799	594	24	algorithmic	algorithmic	ADJ
gs-3799	594	25	logic	logic	NOUN
gs-3799	594	26	in	in	ADP
gs-3799	594	27	isolation	isolation	NOUN
gs-3799	594	28	,	,	PUNCT
gs-3799	594	29	but	but	CCONJ
gs-3799	594	30	by	by	ADP
gs-3799	594	31	integrated	integrate	VERB
gs-3799	594	32	,	,	PUNCT
gs-3799	594	33	intelligent	intelligent	ADJ
gs-3799	594	34	,	,	PUNCT
gs-3799	594	35	anticipatory	anticipatory	ADJ
gs-3799	594	36	,	,	PUNCT
gs-3799	594	37	and	and	CCONJ
gs-3799	594	38	biologically	biologically	ADV
gs-3799	594	39	-	-	PUNCT
gs-3799	594	40	aware	aware	ADJ
gs-3799	594	41	systems	system	NOUN
gs-3799	594	42	.	.	PUNCT
gs-3799	595	1	as	as	SCONJ
gs-3799	595	2	these	these	DET
gs-3799	595	3	platforms	platform	NOUN
gs-3799	595	4	continue	continue	VERB
gs-3799	595	5	to	to	PART
gs-3799	595	6	evolve	evolve	VERB
gs-3799	595	7	,	,	PUNCT
gs-3799	595	8	they	they	PRON
gs-3799	595	9	promise	promise	VERB
gs-3799	595	10	to	to	PART
gs-3799	595	11	redefine	redefine	VERB
gs-3799	595	12	intraoperative	intraoperative	ADJ
gs-3799	595	13	excellence	excellence	NOUN
gs-3799	595	14	—	—	PUNCT
gs-3799	595	15	not	not	PART
gs-3799	595	16	through	through	ADP
gs-3799	595	17	standardization	standardization	NOUN
gs-3799	595	18	,	,	PUNCT
gs-3799	595	19	but	but	CCONJ
gs-3799	595	20	through	through	ADP
gs-3799	595	21	hyperindividualization	hyperindividualization	NOUN
gs-3799	595	22	.	.	PUNCT
gs-3799	596	1	the	the	DET
gs-3799	596	2	confluence	confluence	NOUN
gs-3799	596	3	of	of	ADP
gs-3799	596	4	biological	biological	ADJ
gs-3799	596	5	insight	insight	NOUN
gs-3799	596	6	,	,	PUNCT
gs-3799	596	7	computational	computational	ADJ
gs-3799	596	8	sovereignty	sovereignty	NOUN
gs-3799	596	9	,	,	PUNCT
gs-3799	596	10	ethical	ethical	ADJ
gs-3799	596	11	foresight	foresight	NOUN
gs-3799	596	12	,	,	PUNCT
gs-3799	596	13	and	and	CCONJ
gs-3799	596	14	global	global	ADJ
gs-3799	596	15	learning	learning	NOUN
gs-3799	596	16	will	will	AUX
gs-3799	596	17	ultimately	ultimately	ADV
gs-3799	596	18	reposition	reposition	VERB
gs-3799	596	19	cl	cl	NOUN
gs-3799	596	20	-	-	PUNCT
gs-3799	596	21	cpb	cpb	NOUN
gs-3799	596	22	not	not	PART
gs-3799	596	23	just	just	ADV
gs-3799	596	24	as	as	ADP
gs-3799	596	25	a	a	DET
gs-3799	596	26	technological	technological	ADJ
gs-3799	596	27	milestone	milestone	NOUN
gs-3799	596	28	,	,	PUNCT
gs-3799	596	29	but	but	CCONJ
gs-3799	596	30	as	as	ADP
gs-3799	596	31	the	the	DET
gs-3799	596	32	cornerstone	cornerstone	NOUN
gs-3799	596	33	of	of	ADP
gs-3799	596	34	a	a	DET
gs-3799	596	35	new	new	ADJ
gs-3799	596	36	surgical	surgical	ADJ
gs-3799	596	37	philosophy	philosophy	NOUN
gs-3799	596	38	—	—	PUNCT
gs-3799	596	39	one	one	NUM
gs-3799	596	40	where	where	SCONJ
gs-3799	596	41	the	the	DET
gs-3799	596	42	living	live	VERB
gs-3799	596	43	body	body	NOUN
gs-3799	596	44	and	and	CCONJ
gs-3799	596	45	intelligent	intelligent	ADJ
gs-3799	596	46	machine	machine	NOUN
gs-3799	596	47	form	form	VERB
gs-3799	596	48	a	a	DET
gs-3799	596	49	symbiotic	symbiotic	ADJ
gs-3799	596	50	alliance	alliance	NOUN
gs-3799	596	51	.	.	PUNCT
gs-3799	597	1	of	of	ADP
gs-3799	597	2	engineering	engineering	NOUN
gs-3799	597	3	,	,	PUNCT
gs-3799	597	4	medicine	medicine	NOUN
gs-3799	597	5	,	,	PUNCT
gs-3799	597	6	ethics	ethic	NOUN
gs-3799	597	7	,	,	PUNCT
gs-3799	597	8	and	and	CCONJ
gs-3799	597	9	public	public	ADJ
gs-3799	597	10	health	health	NOUN
gs-3799	597	11	.	.	PUNCT
gs-3799	598	1	multi	multi	ADJ
gs-3799	598	2	-	-	ADJ
gs-3799	598	3	scale	scale	ADJ
gs-3799	598	4	temporal	temporal	ADJ
gs-3799	598	5	modeling	modeling	NOUN
gs-3799	598	6	and	and	CCONJ
gs-3799	598	7	interspatial	interspatial	ADJ
gs-3799	598	8	decision	decision	NOUN
gs-3799	598	9	tuning	tune	VERB
gs-3799	598	10	in	in	ADP
gs-3799	598	11	closed	closed	ADJ
gs-3799	598	12	-	-	PUNCT
gs-3799	598	13	loop	loop	NOUN
gs-3799	598	14	systems	system	NOUN
gs-3799	598	15	:	:	PUNCT
gs-3799	598	16	a	a	DET
gs-3799	598	17	major	major	ADJ
gs-3799	598	18	advancement	advancement	NOUN
gs-3799	598	19	in	in	ADP
gs-3799	598	20	the	the	DET
gs-3799	598	21	sophistication	sophistication	NOUN
gs-3799	598	22	of	of	ADP
gs-3799	598	23	closed	closed	ADJ
gs-3799	598	24	-	-	PUNCT
gs-3799	598	25	loop	loop	NOUN
gs-3799	598	26	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	598	27	bypass	bypass	NOUN
gs-3799	598	28	(	(	PUNCT
gs-3799	598	29	cl	cl	NOUN
gs-3799	598	30	-	-	PUNCT
gs-3799	598	31	cpb	cpb	NOUN
gs-3799	598	32	)	)	PUNCT
gs-3799	598	33	systems	system	NOUN
gs-3799	598	34	is	be	AUX
gs-3799	598	35	the	the	DET
gs-3799	598	36	incorporation	incorporation	NOUN
gs-3799	598	37	of	of	ADP
gs-3799	598	38	multi	multi	ADJ
gs-3799	598	39	-	-	ADJ
gs-3799	598	40	scale	scale	ADJ
gs-3799	598	41	temporal	temporal	ADJ
gs-3799	598	42	modeling	modeling	NOUN
gs-3799	598	43	,	,	PUNCT
gs-3799	598	44	wherein	wherein	SCONJ
gs-3799	598	45	control	control	NOUN
gs-3799	598	46	strategies	strategy	NOUN
gs-3799	598	47	are	be	AUX
gs-3799	598	48	derived	derive	VERB
gs-3799	598	49	not	not	PART
gs-3799	598	50	only	only	ADV
gs-3799	598	51	from	from	ADP
gs-3799	598	52	the	the	DET
gs-3799	598	53	present	present	ADJ
gs-3799	598	54	physiological	physiological	ADJ
gs-3799	598	55	state	state	NOUN
gs-3799	598	56	but	but	CCONJ
gs-3799	598	57	also	also	ADV
gs-3799	598	58	from	from	ADP
gs-3799	598	59	temporally	temporally	ADV
gs-3799	598	60	predictive	predictive	ADJ
gs-3799	598	61	patterns	pattern	NOUN
gs-3799	598	62	extrapolated	extrapolate	VERB
gs-3799	598	63	over	over	ADP
gs-3799	598	64	micro	micro	PROPN
gs-3799	598	65	,	,	PUNCT
gs-3799	598	66	meso	meso	NOUN
gs-3799	598	67	,	,	PUNCT
gs-3799	598	68	and	and	CCONJ
gs-3799	598	69	macro	macro	ADJ
gs-3799	598	70	timeframes	timeframe	NOUN
gs-3799	598	71	.	.	PUNCT
gs-3799	599	1	these	these	DET
gs-3799	599	2	multi	multi	ADJ
gs-3799	599	3	-	-	ADJ
gs-3799	599	4	scale	scale	ADJ
gs-3799	599	5	systems	system	NOUN
gs-3799	599	6	utilize	utilize	VERB
gs-3799	599	7	recursive	recursive	ADJ
gs-3799	599	8	time	time	NOUN
gs-3799	599	9	-	-	PUNCT
gs-3799	599	10	series	series	NOUN
gs-3799	599	11	modeling	modeling	NOUN
gs-3799	599	12	and	and	CCONJ
gs-3799	599	13	dynamic	dynamic	ADJ
gs-3799	599	14	bayesian	bayesian	NOUN
gs-3799	599	15	networks	network	NOUN
gs-3799	599	16	to	to	PART
gs-3799	599	17	account	account	VERB
gs-3799	599	18	for	for	ADP
gs-3799	599	19	both	both	PRON
gs-3799	599	20	fast	fast	ADV
gs-3799	599	21	-	-	PUNCT
gs-3799	599	22	acting	act	VERB
gs-3799	599	23	hemodynamic	hemodynamic	ADJ
gs-3799	599	24	oscillations	oscillation	NOUN
gs-3799	599	25	and	and	CCONJ
gs-3799	599	26	slower	slow	ADJ
gs-3799	599	27	biochemical	biochemical	ADJ
gs-3799	599	28	and	and	CCONJ
gs-3799	599	29	neurohumoral	neurohumoral	ADJ
gs-3799	599	30	trends	trend	NOUN
gs-3799	599	31	.	.	PUNCT
gs-3799	600	1	the	the	DET
gs-3799	600	2	concept	concept	NOUN
gs-3799	600	3	of	of	ADP
gs-3799	600	4	interspatial	interspatial	ADJ
gs-3799	600	5	decision	decision	NOUN
gs-3799	600	6	tuning	tuning	NOUN
gs-3799	600	7	has	have	AUX
gs-3799	600	8	also	also	ADV
gs-3799	600	9	emerged	emerge	VERB
gs-3799	600	10	,	,	PUNCT
gs-3799	600	11	wherein	wherein	SCONJ
gs-3799	600	12	the	the	DET
gs-3799	600	13	controller	controller	NOUN
gs-3799	600	14	does	do	AUX
gs-3799	600	15	not	not	PART
gs-3799	600	16	treat	treat	VERB
gs-3799	600	17	organ	organ	NOUN
gs-3799	600	18	systems	system	NOUN
gs-3799	600	19	as	as	ADP
gs-3799	600	20	discrete	discrete	ADJ
gs-3799	600	21	silos	silo	NOUN
gs-3799	600	22	but	but	CCONJ
gs-3799	600	23	as	as	ADP
gs-3799	600	24	dynamically	dynamically	ADV
gs-3799	600	25	interacting	interact	VERB
gs-3799	600	26	matrices	matrix	NOUN
gs-3799	600	27	.	.	PUNCT
gs-3799	601	1	for	for	ADP
gs-3799	601	2	example	example	NOUN
gs-3799	601	3	,	,	PUNCT
gs-3799	601	4	renal	renal	ADJ
gs-3799	601	5	blood	blood	NOUN
gs-3799	601	6	flow	flow	NOUN
gs-3799	601	7	is	be	AUX
gs-3799	601	8	modulated	modulate	VERB
gs-3799	601	9	not	not	PART
gs-3799	601	10	solely	solely	ADV
gs-3799	601	11	based	base	VERB
gs-3799	601	12	on	on	ADP
gs-3799	601	13	glomerular	glomerular	ADJ
gs-3799	601	14	filtration	filtration	NOUN
gs-3799	601	15	rate	rate	NOUN
gs-3799	601	16	(	(	PUNCT
gs-3799	601	17	gfr	gfr	NOUN
gs-3799	601	18	)	)	PUNCT
gs-3799	601	19	estimates	estimate	NOUN
gs-3799	601	20	but	but	CCONJ
gs-3799	601	21	also	also	ADV
gs-3799	601	22	in	in	ADP
gs-3799	601	23	response	response	NOUN
gs-3799	601	24	to	to	ADP
gs-3799	601	25	liver	liver	NOUN
gs-3799	601	26	perfusion	perfusion	NOUN
gs-3799	601	27	metrics	metric	NOUN
gs-3799	601	28	,	,	PUNCT
gs-3799	601	29	given	give	VERB
gs-3799	601	30	the	the	DET
gs-3799	601	31	role	role	NOUN
gs-3799	601	32	of	of	ADP
gs-3799	601	33	hepatic	hepatic	ADJ
gs-3799	601	34	metabolism	metabolism	NOUN
gs-3799	601	35	in	in	ADP
gs-3799	601	36	systemic	systemic	ADJ
gs-3799	601	37	toxin	toxin	NOUN
gs-3799	601	38	clearance	clearance	NOUN
gs-3799	601	39	and	and	CCONJ
gs-3799	601	40	immunomodulation	immunomodulation	NOUN
gs-3799	601	41	.	.	PUNCT
gs-3799	602	1	this	this	DET
gs-3799	602	2	organ	organ	NOUN
gs-3799	602	3	-	-	PUNCT
gs-3799	602	4	to	to	ADP
gs-3799	602	5	-	-	PUNCT
gs-3799	602	6	organ	organ	NOUN
gs-3799	602	7	crosstalk	crosstalk	NOUN
gs-3799	602	8	represents	represent	VERB
gs-3799	602	9	a	a	DET
gs-3799	602	10	move	move	NOUN
gs-3799	602	11	from	from	ADP
gs-3799	602	12	single	single	ADJ
gs-3799	602	13	-	-	PUNCT
gs-3799	602	14	loop	loop	NOUN
gs-3799	602	15	closed	closed	ADJ
gs-3799	602	16	feedback	feedback	NOUN
gs-3799	602	17	to	to	ADP
gs-3799	602	18	nested	nested	ADJ
gs-3799	602	19	,	,	PUNCT
gs-3799	602	20	relational	relational	ADJ
gs-3799	602	21	,	,	PUNCT
gs-3799	602	22	and	and	CCONJ
gs-3799	602	23	hierarchically	hierarchically	ADV
gs-3799	602	24	-	-	PUNCT
gs-3799	602	25	layered	layered	ADJ
gs-3799	602	26	control	control	NOUN
gs-3799	602	27	logic	logic	NOUN
gs-3799	602	28	.	.	PUNCT
gs-3799	603	1	cardio	cardio	NOUN
gs-3799	603	2	-	-	PUNCT
gs-3799	603	3	renal	renal	ADJ
gs-3799	603	4	-	-	PUNCT
gs-3799	603	5	hepatic	hepatic	NOUN
gs-3799	603	6	axis	axis	NOUN
gs-3799	603	7	in	in	ADP
gs-3799	603	8	pharmacologic	pharmacologic	ADJ
gs-3799	603	9	microregulation	microregulation	NOUN
gs-3799	603	10	:	:	PUNCT
gs-3799	604	1	the	the	DET
gs-3799	604	2	emergent	emergent	ADJ
gs-3799	604	3	appreciation	appreciation	NOUN
gs-3799	604	4	of	of	ADP
gs-3799	604	5	the	the	DET
gs-3799	604	6	cardio	cardio	NOUN
gs-3799	604	7	-	-	PUNCT
gs-3799	604	8	renal	renal	ADJ
gs-3799	604	9	-	-	PUNCT
gs-3799	604	10	hepatic	hepatic	NOUN
gs-3799	604	11	axis	axis	NOUN
gs-3799	604	12	has	have	AUX
gs-3799	604	13	redefined	redefine	VERB
gs-3799	604	14	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	604	15	regulation	regulation	NOUN
gs-3799	604	16	during	during	ADP
gs-3799	604	17	cpb	cpb	PROPN
gs-3799	604	18	.	.	PUNCT
gs-3799	605	1	traditional	traditional	ADJ
gs-3799	605	2	strategies	strategy	NOUN
gs-3799	605	3	often	often	ADV
gs-3799	605	4	failed	fail	VERB
gs-3799	605	5	to	to	PART
gs-3799	605	6	integrate	integrate	VERB
gs-3799	605	7	the	the	DET
gs-3799	605	8	interdependence	interdependence	NOUN
gs-3799	605	9	of	of	ADP
gs-3799	605	10	these	these	DET
gs-3799	605	11	systems	system	NOUN
gs-3799	605	12	,	,	PUNCT
gs-3799	605	13	resulting	result	VERB
gs-3799	605	14	in	in	ADP
gs-3799	605	15	episodes	episode	NOUN
gs-3799	605	16	of	of	ADP
gs-3799	605	17	perfusion	perfusion	NOUN
gs-3799	605	18	mismatch	mismatch	NOUN
gs-3799	605	19	,	,	PUNCT
gs-3799	605	20	drug	drug	NOUN
gs-3799	605	21	accumulation	accumulation	NOUN
gs-3799	605	22	,	,	PUNCT
gs-3799	605	23	and	and	CCONJ
gs-3799	605	24	metabolic	metabolic	NOUN
gs-3799	605	25	instability	instability	NOUN
gs-3799	605	26	.	.	PUNCT
gs-3799	606	1	advanced	advanced	ADJ
gs-3799	606	2	cl	cl	NOUN
gs-3799	606	3	-	-	PUNCT
gs-3799	606	4	cpb	cpb	NOUN
gs-3799	606	5	platforms	platform	NOUN
gs-3799	606	6	now	now	ADV
gs-3799	606	7	employ	employ	VERB
gs-3799	606	8	multi	multi	ADJ
gs-3799	606	9	-	-	ADJ
gs-3799	606	10	agent	agent	ADJ
gs-3799	606	11	pharmacologic	pharmacologic	ADJ
gs-3799	606	12	microsystems	microsystem	NOUN
gs-3799	606	13	capable	capable	ADJ
gs-3799	606	14	of	of	ADP
gs-3799	606	15	evaluating	evaluate	VERB
gs-3799	606	16	hepatic	hepatic	ADJ
gs-3799	606	17	enzyme	enzyme	NOUN
gs-3799	606	18	clearance	clearance	NOUN
gs-3799	606	19	kinetics	kinetic	NOUN
gs-3799	606	20	,	,	PUNCT
gs-3799	606	21	renal	renal	ADJ
gs-3799	606	22	filtration	filtration	NOUN
gs-3799	606	23	fluxes	flux	NOUN
gs-3799	606	24	,	,	PUNCT
gs-3799	606	25	and	and	CCONJ
gs-3799	606	26	cardiac	cardiac	ADJ
gs-3799	606	27	output	output	NOUN
gs-3799	606	28	simultaneously.these	simultaneously.these	PROPN
gs-3799	606	29	systems	system	NOUN
gs-3799	606	30	have	have	AUX
gs-3799	606	31	demonstrated	demonstrate	VERB
gs-3799	606	32	efficacy	efficacy	NOUN
gs-3799	606	33	in	in	ADP
gs-3799	606	34	dynamic	dynamic	ADJ
gs-3799	606	35	drug	drug	NOUN
gs-3799	606	36	re	re	NOUN
gs-3799	606	37	-	-	VERB
gs-3799	606	38	dosing	dosing	ADJ
gs-3799	606	39	,	,	PUNCT
gs-3799	606	40	particularly	particularly	ADV
gs-3799	606	41	for	for	ADP
gs-3799	606	42	agents	agent	NOUN
gs-3799	606	43	with	with	ADP
gs-3799	606	44	narrow	narrow	ADJ
gs-3799	606	45	therapeutic	therapeutic	ADJ
gs-3799	606	46	windows	window	NOUN
gs-3799	606	47	like	like	ADP
gs-3799	606	48	milrinone	milrinone	NOUN
gs-3799	606	49	,	,	PUNCT
gs-3799	606	50	vasopressin	vasopressin	NOUN
gs-3799	606	51	,	,	PUNCT
gs-3799	606	52	or	or	CCONJ
gs-3799	606	53	methylene	methylene	NOUN
gs-3799	606	54	blue	blue	NOUN
gs-3799	606	55	.	.	PUNCT
gs-3799	607	1	in	in	ADP
gs-3799	607	2	cases	case	NOUN
gs-3799	607	3	of	of	ADP
gs-3799	607	4	low	low	ADJ
gs-3799	607	5	cardiac	cardiac	ADJ
gs-3799	607	6	output	output	NOUN
gs-3799	607	7	syndrome	syndrome	NOUN
gs-3799	607	8	(	(	PUNCT
gs-3799	607	9	lcos	lco	NOUN
gs-3799	607	10	)	)	PUNCT
gs-3799	607	11	,	,	PUNCT
gs-3799	607	12	the	the	DET
gs-3799	607	13	system	system	NOUN
gs-3799	607	14	can	can	AUX
gs-3799	607	15	simultaneously	simultaneously	ADV
gs-3799	607	16	adjust	adjust	VERB
gs-3799	607	17	inotrope	inotrope	NOUN
gs-3799	607	18	dose	dose	NOUN
gs-3799	607	19	,	,	PUNCT
gs-3799	607	20	fluid	fluid	ADJ
gs-3799	607	21	shifts	shift	NOUN
gs-3799	607	22	,	,	PUNCT
gs-3799	607	23	and	and	CCONJ
gs-3799	607	24	hepatic	hepatic	ADJ
gs-3799	607	25	extraction	extraction	NOUN
gs-3799	607	26	ratios	ratio	NOUN
gs-3799	607	27	to	to	PART
gs-3799	607	28	avoid	avoid	VERB
gs-3799	607	29	iatrogenic	iatrogenic	ADJ
gs-3799	607	30	georgian	georgian	NOUN
gs-3799	607	31	scientists/	scientists/	NUM
gs-3799	607	32	.	.	PUNCT
gs-3799	608	1	7	7	NUM
gs-3799	608	2	n	n	PRON
gs-3799	608	3	2	2	NUM
gs-3799	608	4	,	,	PUNCT
gs-3799	608	5	2025	2025	NUM
gs-3799	608	6	410	410	NUM
gs-3799	608	7	hepatotoxicity	hepatotoxicity	NOUN
gs-3799	608	8	or	or	CCONJ
gs-3799	608	9	renal	renal	ADJ
gs-3799	608	10	vasoconstriction	vasoconstriction	NOUN
gs-3799	608	11	.	.	PUNCT
gs-3799	609	1	early	early	ADJ
gs-3799	609	2	studies	study	NOUN
gs-3799	609	3	suggest	suggest	VERB
gs-3799	609	4	this	this	DET
gs-3799	609	5	tri	tri	ADJ
gs-3799	609	6	-	-	ADJ
gs-3799	609	7	axis	axis	ADJ
gs-3799	609	8	regulation	regulation	NOUN
gs-3799	609	9	reduces	reduce	VERB
gs-3799	609	10	acute	acute	ADJ
gs-3799	609	11	kidney	kidney	NOUN
gs-3799	609	12	injury	injury	NOUN
gs-3799	609	13	by	by	ADP
gs-3799	609	14	up	up	ADP
gs-3799	609	15	to	to	PART
gs-3799	609	16	47	47	NUM
gs-3799	609	17	%	%	NOUN
gs-3799	609	18	and	and	CCONJ
gs-3799	609	19	shortens	shorten	VERB
gs-3799	609	20	icu	icu	PROPN
gs-3799	609	21	stay	stay	VERB
gs-3799	609	22	by	by	ADP
gs-3799	609	23	a	a	DET
gs-3799	609	24	mean	mean	NOUN
gs-3799	609	25	of	of	ADP
gs-3799	609	26	1.5	1.5	NUM
gs-3799	609	27	days	day	NOUN
gs-3799	609	28	in	in	ADP
gs-3799	609	29	high	high	ADJ
gs-3799	609	30	-	-	PUNCT
gs-3799	609	31	risk	risk	NOUN
gs-3799	609	32	procedures	procedure	NOUN
gs-3799	609	33	.	.	PUNCT
gs-3799	610	1	neurovascular	neurovascular	ADJ
gs-3799	610	2	coupling	coupling	NOUN
gs-3799	610	3	and	and	CCONJ
gs-3799	610	4	perfusion	perfusion	NOUN
gs-3799	610	5	-	-	PUNCT
gs-3799	610	6	driven	drive	VERB
gs-3799	610	7	connectome	connectome	PROPN
gs-3799	610	8	preservation	preservation	NOUN
gs-3799	610	9	:	:	PUNCT
gs-3799	610	10	the	the	DET
gs-3799	610	11	cerebral	cerebral	ADJ
gs-3799	610	12	consequences	consequence	NOUN
gs-3799	610	13	of	of	ADP
gs-3799	610	14	extracorporeal	extracorporeal	NOUN
gs-3799	610	15	circulation	circulation	NOUN
gs-3799	610	16	remain	remain	VERB
gs-3799	610	17	profound	profound	ADJ
gs-3799	610	18	.	.	PUNCT
gs-3799	611	1	increasingly	increasingly	ADV
gs-3799	611	2	,	,	PUNCT
gs-3799	611	3	attention	attention	NOUN
gs-3799	611	4	is	be	AUX
gs-3799	611	5	turning	turn	VERB
gs-3799	611	6	to	to	ADP
gs-3799	611	7	neurovascular	neurovascular	ADJ
gs-3799	611	8	coupling	coupling	NOUN
gs-3799	611	9	(	(	PUNCT
gs-3799	611	10	nvc)—the	nvc)—the	DET
gs-3799	611	11	intricate	intricate	ADJ
gs-3799	611	12	synchronization	synchronization	NOUN
gs-3799	611	13	between	between	ADP
gs-3799	611	14	cerebral	cerebral	ADJ
gs-3799	611	15	metabolic	metabolic	NOUN
gs-3799	611	16	demand	demand	NOUN
gs-3799	611	17	and	and	CCONJ
gs-3799	611	18	vascular	vascular	ADJ
gs-3799	611	19	supply	supply	NOUN
gs-3799	611	20	.	.	PUNCT
gs-3799	612	1	nvc	nvc	NOUN
gs-3799	612	2	is	be	AUX
gs-3799	612	3	often	often	ADV
gs-3799	612	4	disrupted	disrupt	VERB
gs-3799	612	5	during	during	ADP
gs-3799	612	6	cpb	cpb	PROPN
gs-3799	612	7	due	due	ADP
gs-3799	612	8	to	to	ADP
gs-3799	612	9	fluctuating	fluctuate	VERB
gs-3799	612	10	co	co	NOUN
gs-3799	612	11	levels	level	NOUN
gs-3799	612	12	,	,	PUNCT
gs-3799	612	13	hemodilution	hemodilution	NOUN
gs-3799	612	14	,	,	PUNCT
gs-3799	612	15	and	and	CCONJ
gs-3799	612	16	embolic	embolic	ADJ
gs-3799	612	17	burden	burden	NOUN
gs-3799	612	18	.	.	PUNCT
gs-3799	613	1	contemporary	contemporary	ADJ
gs-3799	613	2	cl	cl	NOUN
gs-3799	613	3	-	-	PUNCT
gs-3799	613	4	cpb	cpb	NOUN
gs-3799	613	5	systems	system	NOUN
gs-3799	613	6	now	now	ADV
gs-3799	613	7	include	include	VERB
gs-3799	613	8	deep	deep	ADJ
gs-3799	613	9	brain	brain	NOUN
gs-3799	613	10	signal	signal	NOUN
gs-3799	613	11	analytics	analytic	NOUN
gs-3799	613	12	,	,	PUNCT
gs-3799	613	13	derived	derive	VERB
gs-3799	613	14	from	from	ADP
gs-3799	613	15	high	high	ADJ
gs-3799	613	16	-	-	PUNCT
gs-3799	613	17	resolution	resolution	NOUN
gs-3799	613	18	eeg	eeg	NOUN
gs-3799	613	19	,	,	PUNCT
gs-3799	613	20	functional	functional	ADJ
gs-3799	613	21	near	near	ADV
gs-3799	613	22	-	-	PUNCT
gs-3799	613	23	infrared	infrared	ADJ
gs-3799	613	24	spectroscopy	spectroscopy	NOUN
gs-3799	613	25	(	(	PUNCT
gs-3799	613	26	fnirs	fnir	NOUN
gs-3799	613	27	)	)	PUNCT
gs-3799	613	28	,	,	PUNCT
gs-3799	613	29	and	and	CCONJ
gs-3799	613	30	jugular	jugular	ADJ
gs-3799	613	31	bulb	bulb	NOUN
gs-3799	613	32	oximetry	oximetry	NOUN
gs-3799	613	33	.	.	PUNCT
gs-3799	614	1	these	these	DET
gs-3799	614	2	platforms	platform	NOUN
gs-3799	614	3	aim	aim	VERB
gs-3799	614	4	to	to	PART
gs-3799	614	5	preserve	preserve	VERB
gs-3799	614	6	the	the	DET
gs-3799	614	7	functional	functional	ADJ
gs-3799	614	8	connectome	connectome	NOUN
gs-3799	614	9	,	,	PUNCT
gs-3799	614	10	or	or	CCONJ
gs-3799	614	11	the	the	DET
gs-3799	614	12	pattern	pattern	NOUN
gs-3799	614	13	of	of	ADP
gs-3799	614	14	communication	communication	NOUN
gs-3799	614	15	between	between	ADP
gs-3799	614	16	brain	brain	NOUN
gs-3799	614	17	regions	region	NOUN
gs-3799	614	18	,	,	PUNCT
gs-3799	614	19	especially	especially	ADV
gs-3799	614	20	within	within	ADP
gs-3799	614	21	the	the	DET
gs-3799	614	22	default	default	NOUN
gs-3799	614	23	mode	mode	NOUN
gs-3799	614	24	network	network	NOUN
gs-3799	614	25	and	and	CCONJ
gs-3799	614	26	frontoparietal	frontoparietal	ADJ
gs-3799	614	27	attentional	attentional	ADJ
gs-3799	614	28	hubs	hub	NOUN
gs-3799	614	29	.	.	PUNCT
gs-3799	615	1	when	when	SCONJ
gs-3799	615	2	loss	loss	NOUN
gs-3799	615	3	of	of	ADP
gs-3799	615	4	synchronization	synchronization	NOUN
gs-3799	615	5	is	be	AUX
gs-3799	615	6	detected	detect	VERB
gs-3799	615	7	—	—	PUNCT
gs-3799	615	8	such	such	ADJ
gs-3799	615	9	as	as	ADP
gs-3799	615	10	during	during	ADP
gs-3799	615	11	deep	deep	ADJ
gs-3799	615	12	hypothermic	hypothermic	ADJ
gs-3799	615	13	circulatory	circulatory	ADJ
gs-3799	615	14	arrest	arrest	NOUN
gs-3799	615	15	—	—	PUNCT
gs-3799	615	16	the	the	DET
gs-3799	615	17	system	system	NOUN
gs-3799	615	18	modulates	modulate	VERB
gs-3799	615	19	cerebral	cerebral	ADJ
gs-3799	615	20	perfusion	perfusion	NOUN
gs-3799	615	21	independently	independently	ADV
gs-3799	615	22	of	of	ADP
gs-3799	615	23	systemic	systemic	ADJ
gs-3799	615	24	parameters	parameter	NOUN
gs-3799	615	25	.	.	PUNCT
gs-3799	616	1	this	this	DET
gs-3799	616	2	shift	shift	NOUN
gs-3799	616	3	from	from	ADP
gs-3799	616	4	global	global	ADJ
gs-3799	616	5	to	to	ADP
gs-3799	616	6	regional	regional	ADJ
gs-3799	616	7	cerebral	cerebral	ADJ
gs-3799	616	8	optimization	optimization	NOUN
gs-3799	616	9	marks	mark	VERB
gs-3799	616	10	a	a	DET
gs-3799	616	11	critical	critical	ADJ
gs-3799	616	12	advancement	advancement	NOUN
gs-3799	616	13	in	in	ADP
gs-3799	616	14	neuroprotection	neuroprotection	NOUN
gs-3799	616	15	and	and	CCONJ
gs-3799	616	16	postoperative	postoperative	ADJ
gs-3799	616	17	cognitive	cognitive	ADJ
gs-3799	616	18	trajectory	trajectory	NOUN
gs-3799	616	19	.	.	PUNCT
gs-3799	617	1	ethical	ethical	ADJ
gs-3799	617	2	human	human	ADJ
gs-3799	617	3	-	-	PUNCT
gs-3799	617	4	machine	machine	NOUN
gs-3799	617	5	interfacing	interfacing	NOUN
gs-3799	617	6	and	and	CCONJ
gs-3799	617	7	cognitive	cognitive	ADJ
gs-3799	617	8	transfer	transfer	NOUN
gs-3799	617	9	thresholds	threshold	VERB
gs-3799	617	10	:	:	PUNCT
gs-3799	617	11	as	as	SCONJ
gs-3799	617	12	cl	cl	NOUN
gs-3799	617	13	-	-	PUNCT
gs-3799	617	14	cpb	cpb	NOUN
gs-3799	617	15	becomes	become	VERB
gs-3799	617	16	more	more	ADV
gs-3799	617	17	autonomous	autonomous	ADJ
gs-3799	617	18	,	,	PUNCT
gs-3799	617	19	the	the	DET
gs-3799	617	20	interface	interface	NOUN
gs-3799	617	21	between	between	ADP
gs-3799	617	22	machine	machine	NOUN
gs-3799	617	23	cognition	cognition	NOUN
gs-3799	617	24	and	and	CCONJ
gs-3799	617	25	human	human	ADJ
gs-3799	617	26	ethical	ethical	ADJ
gs-3799	617	27	oversight	oversight	NOUN
gs-3799	617	28	becomes	become	VERB
gs-3799	617	29	a	a	DET
gs-3799	617	30	focal	focal	ADJ
gs-3799	617	31	point	point	NOUN
gs-3799	617	32	.	.	PUNCT
gs-3799	618	1	systems	system	NOUN
gs-3799	618	2	are	be	AUX
gs-3799	618	3	now	now	ADV
gs-3799	618	4	designed	design	VERB
gs-3799	618	5	to	to	PART
gs-3799	618	6	operate	operate	VERB
gs-3799	618	7	with	with	ADP
gs-3799	618	8	cognitive	cognitive	ADJ
gs-3799	618	9	transfer	transfer	NOUN
gs-3799	618	10	thresholds	threshold	NOUN
gs-3799	618	11	—	—	PUNCT
gs-3799	618	12	predefined	predefine	VERB
gs-3799	618	13	conditions	condition	NOUN
gs-3799	618	14	under	under	ADP
gs-3799	618	15	which	which	PRON
gs-3799	618	16	full	full	ADJ
gs-3799	618	17	decision	decision	NOUN
gs-3799	618	18	-	-	PUNCT
gs-3799	618	19	making	make	VERB
gs-3799	618	20	authority	authority	NOUN
gs-3799	618	21	transitions	transition	NOUN
gs-3799	618	22	from	from	ADP
gs-3799	618	23	human	human	NOUN
gs-3799	618	24	to	to	ADP
gs-3799	618	25	machine	machine	NOUN
gs-3799	618	26	or	or	CCONJ
gs-3799	618	27	vice	vice	NOUN
gs-3799	618	28	versa	versa	ADV
gs-3799	618	29	.	.	PUNCT
gs-3799	619	1	these	these	DET
gs-3799	619	2	thresholds	threshold	NOUN
gs-3799	619	3	are	be	AUX
gs-3799	619	4	based	base	VERB
gs-3799	619	5	not	not	PART
gs-3799	619	6	just	just	ADV
gs-3799	619	7	on	on	ADP
gs-3799	619	8	technical	technical	ADJ
gs-3799	619	9	data	datum	NOUN
gs-3799	619	10	(	(	PUNCT
gs-3799	619	11	e.g.	e.g.	ADV
gs-3799	619	12	,	,	PUNCT
gs-3799	619	13	oxygen	oxygen	NOUN
gs-3799	619	14	saturation	saturation	NOUN
gs-3799	619	15	falling	fall	VERB
gs-3799	619	16	below	below	ADP
gs-3799	619	17	a	a	DET
gs-3799	619	18	set	set	NOUN
gs-3799	619	19	point	point	NOUN
gs-3799	619	20	)	)	PUNCT
gs-3799	619	21	but	but	CCONJ
gs-3799	619	22	also	also	ADV
gs-3799	619	23	on	on	ADP
gs-3799	619	24	synthetic	synthetic	ADJ
gs-3799	619	25	ethical	ethical	ADJ
gs-3799	619	26	heuristics	heuristic	NOUN
gs-3799	619	27	,	,	PUNCT
gs-3799	619	28	such	such	ADJ
gs-3799	619	29	as	as	ADP
gs-3799	619	30	multi	multi	ADJ
gs-3799	619	31	-	-	ADJ
gs-3799	619	32	objective	objective	ADJ
gs-3799	619	33	optimization	optimization	NOUN
gs-3799	619	34	failures	failure	NOUN
gs-3799	619	35	,	,	PUNCT
gs-3799	619	36	algorithmic	algorithmic	ADJ
gs-3799	619	37	uncertainty	uncertainty	NOUN
gs-3799	619	38	margins	margin	NOUN
gs-3799	619	39	,	,	PUNCT
gs-3799	619	40	or	or	CCONJ
gs-3799	619	41	cross	cross	ADJ
gs-3799	619	42	-	-	ADJ
gs-3799	619	43	agent	agent	ADJ
gs-3799	619	44	conflict	conflict	NOUN
gs-3799	619	45	in	in	ADP
gs-3799	619	46	real	real	ADJ
gs-3799	619	47	-	-	PUNCT
gs-3799	619	48	time	time	NOUN
gs-3799	619	49	decisions	decision	NOUN
gs-3799	619	50	.	.	PUNCT
gs-3799	620	1	some	some	DET
gs-3799	620	2	platforms	platform	NOUN
gs-3799	620	3	now	now	ADV
gs-3799	620	4	incorporate	incorporate	VERB
gs-3799	620	5	moral	moral	ADJ
gs-3799	620	6	decision	decision	NOUN
gs-3799	620	7	frameworks	framework	NOUN
gs-3799	620	8	,	,	PUNCT
gs-3799	620	9	adapted	adapt	VERB
gs-3799	620	10	from	from	ADP
gs-3799	620	11	bioethical	bioethical	PROPN
gs-3799	620	12	ai	ai	PROPN
gs-3799	620	13	literature	literature	NOUN
gs-3799	620	14	,	,	PUNCT
gs-3799	620	15	to	to	PART
gs-3799	620	16	determine	determine	VERB
gs-3799	620	17	actions	action	NOUN
gs-3799	620	18	when	when	SCONJ
gs-3799	620	19	goals	goal	NOUN
gs-3799	620	20	such	such	ADJ
gs-3799	620	21	as	as	ADP
gs-3799	620	22	survival	survival	NOUN
gs-3799	620	23	and	and	CCONJ
gs-3799	620	24	organ	organ	NOUN
gs-3799	620	25	preservation	preservation	NOUN
gs-3799	620	26	are	be	AUX
gs-3799	620	27	in	in	ADP
gs-3799	620	28	tension	tension	NOUN
gs-3799	620	29	.	.	PUNCT
gs-3799	621	1	for	for	ADP
gs-3799	621	2	example	example	NOUN
gs-3799	621	3	,	,	PUNCT
gs-3799	621	4	in	in	ADP
gs-3799	621	5	extreme	extreme	ADJ
gs-3799	621	6	hypotension	hypotension	NOUN
gs-3799	621	7	with	with	ADP
gs-3799	621	8	concurrent	concurrent	ADJ
gs-3799	621	9	bleeding	bleeding	NOUN
gs-3799	621	10	,	,	PUNCT
gs-3799	621	11	the	the	DET
gs-3799	621	12	system	system	NOUN
gs-3799	621	13	may	may	AUX
gs-3799	621	14	prioritize	prioritize	VERB
gs-3799	621	15	cerebral	cerebral	ADJ
gs-3799	621	16	flow	flow	NOUN
gs-3799	621	17	over	over	ADP
gs-3799	621	18	renal	renal	ADJ
gs-3799	621	19	function	function	NOUN
gs-3799	621	20	—	—	PUNCT
gs-3799	621	21	yet	yet	CCONJ
gs-3799	621	22	only	only	ADV
gs-3799	621	23	within	within	ADP
gs-3799	621	24	ethically	ethically	ADV
gs-3799	621	25	vetted	vet	VERB
gs-3799	621	26	parameter	parameter	NOUN
gs-3799	621	27	ranges	range	NOUN
gs-3799	621	28	approved	approve	VERB
gs-3799	621	29	preoperatively	preoperatively	ADV
gs-3799	621	30	by	by	ADP
gs-3799	621	31	clinicians	clinician	NOUN
gs-3799	621	32	.	.	PUNCT
gs-3799	622	1	entropic	entropic	ADJ
gs-3799	622	2	control	control	NOUN
gs-3799	622	3	theory	theory	NOUN
gs-3799	622	4	and	and	CCONJ
gs-3799	622	5	metabolic	metabolic	NOUN
gs-3799	622	6	phase	phase	NOUN
gs-3799	622	7	shifts	shift	NOUN
gs-3799	622	8	:	:	PUNCT
gs-3799	623	1	the	the	DET
gs-3799	623	2	concept	concept	NOUN
gs-3799	623	3	of	of	ADP
gs-3799	623	4	metabolic	metabolic	NOUN
gs-3799	623	5	entropy	entropy	NOUN
gs-3799	623	6	—	—	PUNCT
gs-3799	623	7	a	a	DET
gs-3799	623	8	measure	measure	NOUN
gs-3799	623	9	of	of	ADP
gs-3799	623	10	biochemical	biochemical	ADJ
gs-3799	623	11	disorder	disorder	NOUN
gs-3799	623	12	—	—	PUNCT
gs-3799	623	13	has	have	AUX
gs-3799	623	14	been	be	AUX
gs-3799	623	15	formalized	formalize	VERB
gs-3799	623	16	in	in	ADP
gs-3799	623	17	cl	cl	NOUN
gs-3799	623	18	-	-	PUNCT
gs-3799	623	19	cpb	cpb	NOUN
gs-3799	623	20	logic	logic	NOUN
gs-3799	623	21	as	as	ADP
gs-3799	623	22	a	a	DET
gs-3799	623	23	control	control	NOUN
gs-3799	623	24	variable	variable	NOUN
gs-3799	623	25	.	.	PUNCT
gs-3799	624	1	by	by	ADP
gs-3799	624	2	analyzing	analyze	VERB
gs-3799	624	3	high	high	ADJ
gs-3799	624	4	-	-	PUNCT
gs-3799	624	5	resolution	resolution	NOUN
gs-3799	624	6	metabolomics	metabolomic	NOUN
gs-3799	624	7	,	,	PUNCT
gs-3799	624	8	lactate	lactate	NOUN
gs-3799	624	9	kinetics	kinetic	NOUN
gs-3799	624	10	,	,	PUNCT
gs-3799	624	11	and	and	CCONJ
gs-3799	624	12	intracellular	intracellular	ADJ
gs-3799	624	13	ph	ph	ADJ
gs-3799	624	14	dynamics	dynamic	NOUN
gs-3799	624	15	,	,	PUNCT
gs-3799	624	16	systems	system	NOUN
gs-3799	624	17	compute	compute	VERB
gs-3799	624	18	an	an	DET
gs-3799	624	19	entropy	entropy	PROPN
gs-3799	624	20	index	index	NOUN
gs-3799	624	21	,	,	PUNCT
gs-3799	624	22	guiding	guide	VERB
gs-3799	624	23	interventions	intervention	NOUN
gs-3799	624	24	to	to	PART
gs-3799	624	25	reverse	reverse	VERB
gs-3799	624	26	catabolic	catabolic	ADJ
gs-3799	624	27	collapse	collapse	NOUN
gs-3799	624	28	.	.	PUNCT
gs-3799	625	1	in	in	ADP
gs-3799	625	2	scenarios	scenario	NOUN
gs-3799	625	3	such	such	ADJ
gs-3799	625	4	as	as	ADP
gs-3799	625	5	rewarming	rewarme	VERB
gs-3799	625	6	from	from	ADP
gs-3799	625	7	hypothermia	hypothermia	NOUN
gs-3799	625	8	or	or	CCONJ
gs-3799	625	9	reperfusion	reperfusion	NOUN
gs-3799	625	10	after	after	ADP
gs-3799	625	11	aortic	aortic	ADJ
gs-3799	625	12	cross	cross	NOUN
gs-3799	625	13	-	-	ADJ
gs-3799	625	14	clamping	clamping	NOUN
gs-3799	625	15	,	,	PUNCT
gs-3799	625	16	entropy	entropy	NOUN
gs-3799	625	17	surges	surge	NOUN
gs-3799	625	18	are	be	AUX
gs-3799	625	19	predictive	predictive	ADJ
gs-3799	625	20	of	of	ADP
gs-3799	625	21	organ	organ	NOUN
gs-3799	625	22	dysfunction	dysfunction	NOUN
gs-3799	625	23	.	.	PUNCT
gs-3799	626	1	next	next	ADJ
gs-3799	626	2	-	-	PUNCT
gs-3799	626	3	generation	generation	NOUN
gs-3799	626	4	systems	system	NOUN
gs-3799	626	5	now	now	ADV
gs-3799	626	6	deploy	deploy	VERB
gs-3799	626	7	phase	phase	NOUN
gs-3799	626	8	-	-	PUNCT
gs-3799	626	9	shift	shift	NOUN
gs-3799	626	10	algorithms	algorithm	NOUN
gs-3799	626	11	to	to	PART
gs-3799	626	12	forecast	forecast	VERB
gs-3799	626	13	impending	impending	ADJ
gs-3799	626	14	metabolic	metabolic	ADJ
gs-3799	626	15	decompensation	decompensation	NOUN
gs-3799	626	16	and	and	CCONJ
gs-3799	626	17	preemptively	preemptively	ADV
gs-3799	626	18	adjust	adjust	VERB
gs-3799	626	19	perfusion	perfusion	NOUN
gs-3799	626	20	,	,	PUNCT
gs-3799	626	21	substrate	substrate	NOUN
gs-3799	626	22	supplementation	supplementation	NOUN
gs-3799	626	23	,	,	PUNCT
gs-3799	626	24	and	and	CCONJ
gs-3799	626	25	vasoactive	vasoactive	ADJ
gs-3799	626	26	support	support	NOUN
gs-3799	626	27	.	.	PUNCT
gs-3799	627	1	this	this	DET
gs-3799	627	2	quantum	quantum	NOUN
gs-3799	627	3	-	-	PUNCT
gs-3799	627	4	level	level	NOUN
gs-3799	627	5	approach	approach	NOUN
gs-3799	627	6	,	,	PUNCT
gs-3799	627	7	drawn	draw	VERB
gs-3799	627	8	from	from	ADP
gs-3799	627	9	complexity	complexity	NOUN
gs-3799	627	10	theory	theory	NOUN
gs-3799	627	11	and	and	CCONJ
gs-3799	627	12	thermodynamics	thermodynamic	NOUN
gs-3799	627	13	,	,	PUNCT
gs-3799	627	14	allows	allow	VERB
gs-3799	627	15	bypass	bypass	NOUN
gs-3799	627	16	to	to	PART
gs-3799	627	17	be	be	AUX
gs-3799	627	18	governed	govern	VERB
gs-3799	627	19	not	not	PART
gs-3799	627	20	merely	merely	ADV
gs-3799	627	21	by	by	ADP
gs-3799	627	22	rate	rate	NOUN
gs-3799	627	23	-	-	PUNCT
gs-3799	627	24	based	base	VERB
gs-3799	627	25	variables	variable	NOUN
gs-3799	627	26	but	but	CCONJ
gs-3799	627	27	by	by	ADP
gs-3799	627	28	informationdriven	informationdriven	VERB
gs-3799	627	29	energy	energy	NOUN
gs-3799	627	30	conservation	conservation	NOUN
gs-3799	627	31	.	.	PUNCT
gs-3799	628	1	ai	ai	VERB
gs-3799	628	2	agency	agency	NOUN
gs-3799	628	3	during	during	ADP
gs-3799	628	4	crisis	crisis	NOUN
gs-3799	628	5	states	state	NOUN
gs-3799	628	6	:	:	PUNCT
gs-3799	628	7	decentralized	decentralize	VERB
gs-3799	628	8	autonomic	autonomic	ADJ
gs-3799	628	9	override	override	NOUN
gs-3799	628	10	:	:	PUNCT
gs-3799	628	11	during	during	ADP
gs-3799	628	12	acute	acute	ADJ
gs-3799	628	13	intraoperative	intraoperative	ADJ
gs-3799	628	14	crises	crisis	NOUN
gs-3799	628	15	—	—	PUNCT
gs-3799	628	16	such	such	ADJ
gs-3799	628	17	as	as	ADP
gs-3799	628	18	massive	massive	ADJ
gs-3799	628	19	air	air	NOUN
gs-3799	628	20	embolism	embolism	NOUN
gs-3799	628	21	,	,	PUNCT
gs-3799	628	22	malignant	malignant	ADJ
gs-3799	628	23	arrhythmias	arrhythmia	NOUN
gs-3799	628	24	,	,	PUNCT
gs-3799	628	25	or	or	CCONJ
gs-3799	628	26	sudden	sudden	ADJ
gs-3799	628	27	coagulopathic	coagulopathic	ADJ
gs-3799	628	28	bleeding	bleeding	NOUN
gs-3799	628	29	—	—	PUNCT
gs-3799	628	30	cl	cl	NOUN
gs-3799	628	31	-	-	PUNCT
gs-3799	628	32	cpb	cpb	NOUN
gs-3799	628	33	systems	system	NOUN
gs-3799	628	34	must	must	AUX
gs-3799	628	35	make	make	VERB
gs-3799	628	36	decisions	decision	NOUN
gs-3799	628	37	faster	fast	ADV
gs-3799	628	38	than	than	SCONJ
gs-3799	628	39	human	human	ADJ
gs-3799	628	40	cognition	cognition	NOUN
gs-3799	628	41	allows	allow	VERB
gs-3799	628	42	.	.	PUNCT
gs-3799	629	1	decentralized	decentralize	VERB
gs-3799	629	2	ai	ai	PROPN
gs-3799	629	3	agency	agency	NOUN
gs-3799	629	4	,	,	PUNCT
gs-3799	629	5	wherein	wherein	SCONJ
gs-3799	629	6	different	different	ADJ
gs-3799	629	7	modules	module	NOUN
gs-3799	629	8	operate	operate	VERB
gs-3799	629	9	in	in	ADP
gs-3799	629	10	parallel	parallel	NOUN
gs-3799	629	11	with	with	ADP
gs-3799	629	12	local	local	ADJ
gs-3799	629	13	autonomy	autonomy	NOUN
gs-3799	629	14	,	,	PUNCT
gs-3799	629	15	has	have	AUX
gs-3799	629	16	emerged	emerge	VERB
gs-3799	629	17	as	as	ADP
gs-3799	629	18	a	a	DET
gs-3799	629	19	solution	solution	NOUN
gs-3799	629	20	.	.	PUNCT
gs-3799	630	1	in	in	ADP
gs-3799	630	2	this	this	DET
gs-3799	630	3	framework	framework	NOUN
gs-3799	630	4	,	,	PUNCT
gs-3799	630	5	the	the	DET
gs-3799	630	6	pump	pump	NOUN
gs-3799	630	7	controller	controller	NOUN
gs-3799	630	8	may	may	AUX
gs-3799	630	9	override	override	VERB
gs-3799	630	10	the	the	DET
gs-3799	630	11	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	630	12	controller	controller	NOUN
gs-3799	630	13	to	to	PART
gs-3799	630	14	increase	increase	VERB
gs-3799	630	15	flow	flow	NOUN
gs-3799	630	16	during	during	ADP
gs-3799	630	17	hemorrhage	hemorrhage	NOUN
gs-3799	630	18	,	,	PUNCT
gs-3799	630	19	even	even	ADV
gs-3799	630	20	if	if	SCONJ
gs-3799	630	21	vasopressor	vasopressor	NOUN
gs-3799	630	22	administration	administration	NOUN
gs-3799	630	23	is	be	AUX
gs-3799	630	24	temporarily	temporarily	ADV
gs-3799	630	25	suboptimal	suboptimal	ADJ
gs-3799	630	26	.	.	PUNCT
gs-3799	631	1	georgian	georgian	NOUN
gs-3799	631	2	scientists/	scientists/	NUM
gs-3799	631	3	.	.	PUNCT
gs-3799	632	1	7	7	NUM
gs-3799	632	2	n	n	PRON
gs-3799	632	3	2	2	NUM
gs-3799	632	4	,	,	PUNCT
gs-3799	632	5	2025	2025	NUM
gs-3799	632	6	411	411	NUM
gs-3799	632	7	recent	recent	ADJ
gs-3799	632	8	simulations	simulation	NOUN
gs-3799	632	9	show	show	VERB
gs-3799	632	10	that	that	SCONJ
gs-3799	632	11	modular	modular	ADJ
gs-3799	632	12	ai	ai	VERB
gs-3799	632	13	war	war	NOUN
gs-3799	632	14	rooms	room	NOUN
gs-3799	632	15	—	—	PUNCT
gs-3799	632	16	distributed	distribute	VERB
gs-3799	632	17	processing	processing	NOUN
gs-3799	632	18	nodes	node	NOUN
gs-3799	632	19	that	that	PRON
gs-3799	632	20	emulate	emulate	VERB
gs-3799	632	21	emergency	emergency	NOUN
gs-3799	632	22	consensus	consensus	NOUN
gs-3799	632	23	building	building	NOUN
gs-3799	632	24	—	—	PUNCT
gs-3799	632	25	outperform	outperform	ADJ
gs-3799	632	26	monolithic	monolithic	ADJ
gs-3799	632	27	algorithms	algorithm	NOUN
gs-3799	632	28	.	.	PUNCT
gs-3799	633	1	these	these	DET
gs-3799	633	2	systems	system	NOUN
gs-3799	633	3	reflect	reflect	VERB
gs-3799	633	4	the	the	DET
gs-3799	633	5	architecture	architecture	NOUN
gs-3799	633	6	of	of	ADP
gs-3799	633	7	human	human	ADJ
gs-3799	633	8	trauma	trauma	NOUN
gs-3799	633	9	teams	team	NOUN
gs-3799	633	10	,	,	PUNCT
gs-3799	633	11	where	where	SCONJ
gs-3799	633	12	specialists	specialist	NOUN
gs-3799	633	13	focus	focus	VERB
gs-3799	633	14	on	on	ADP
gs-3799	633	15	domains	domain	NOUN
gs-3799	633	16	but	but	CCONJ
gs-3799	633	17	share	share	VERB
gs-3799	633	18	situational	situational	ADJ
gs-3799	633	19	awareness	awareness	NOUN
gs-3799	633	20	.	.	PUNCT
gs-3799	634	1	the	the	DET
gs-3799	634	2	ai	ai	PROPN
gs-3799	634	3	models	model	NOUN
gs-3799	634	4	have	have	AUX
gs-3799	634	5	been	be	AUX
gs-3799	634	6	trained	train	VERB
gs-3799	634	7	in	in	ADP
gs-3799	634	8	synthetic	synthetic	ADJ
gs-3799	634	9	emergency	emergency	NOUN
gs-3799	634	10	environments	environment	NOUN
gs-3799	634	11	,	,	PUNCT
gs-3799	634	12	allowing	allow	VERB
gs-3799	634	13	robust	robust	ADJ
gs-3799	634	14	decision	decision	NOUN
gs-3799	634	15	-	-	PUNCT
gs-3799	634	16	making	making	NOUN
gs-3799	634	17	even	even	ADV
gs-3799	634	18	in	in	ADP
gs-3799	634	19	unanticipated	unanticipated	ADJ
gs-3799	634	20	scenarios	scenario	NOUN
gs-3799	634	21	.	.	PUNCT
gs-3799	635	1	system	system	NOUN
gs-3799	635	2	psychophysiology	psychophysiology	NOUN
gs-3799	635	3	:	:	PUNCT
gs-3799	635	4	emotional	emotional	ADJ
gs-3799	635	5	intelligence	intelligence	NOUN
gs-3799	635	6	in	in	ADP
gs-3799	635	7	machine	machine	NOUN
gs-3799	635	8	control	control	NOUN
gs-3799	635	9	:	:	PUNCT
gs-3799	635	10	while	while	SCONJ
gs-3799	635	11	seemingly	seemingly	ADV
gs-3799	635	12	speculative	speculative	ADJ
gs-3799	635	13	,	,	PUNCT
gs-3799	635	14	a	a	DET
gs-3799	635	15	new	new	ADJ
gs-3799	635	16	research	research	NOUN
gs-3799	635	17	trajectory	trajectory	NOUN
gs-3799	635	18	explores	explore	VERB
gs-3799	635	19	the	the	DET
gs-3799	635	20	idea	idea	NOUN
gs-3799	635	21	of	of	ADP
gs-3799	635	22	machine	machine	NOUN
gs-3799	635	23	psychophysiology	psychophysiology	NOUN
gs-3799	635	24	—	—	PUNCT
gs-3799	635	25	systems	system	NOUN
gs-3799	635	26	that	that	PRON
gs-3799	635	27	interpret	interpret	VERB
gs-3799	635	28	the	the	DET
gs-3799	635	29	emotional	emotional	ADJ
gs-3799	635	30	and	and	CCONJ
gs-3799	635	31	cognitive	cognitive	ADJ
gs-3799	635	32	states	state	NOUN
gs-3799	635	33	of	of	ADP
gs-3799	635	34	the	the	DET
gs-3799	635	35	surgical	surgical	ADJ
gs-3799	635	36	team	team	NOUN
gs-3799	635	37	.	.	PUNCT
gs-3799	636	1	based	base	VERB
gs-3799	636	2	on	on	ADP
gs-3799	636	3	voice	voice	NOUN
gs-3799	636	4	stress	stress	NOUN
gs-3799	636	5	analysis	analysis	NOUN
gs-3799	636	6	,	,	PUNCT
gs-3799	636	7	gesture	gesture	NOUN
gs-3799	636	8	tracking	tracking	NOUN
gs-3799	636	9	,	,	PUNCT
gs-3799	636	10	and	and	CCONJ
gs-3799	636	11	gaze	gaze	NOUN
gs-3799	636	12	detection	detection	NOUN
gs-3799	636	13	,	,	PUNCT
gs-3799	636	14	some	some	DET
gs-3799	636	15	advanced	advanced	ADJ
gs-3799	636	16	cl	cl	NOUN
gs-3799	636	17	-	-	PUNCT
gs-3799	636	18	cpb	cpb	NOUN
gs-3799	636	19	consoles	console	NOUN
gs-3799	636	20	can	can	AUX
gs-3799	636	21	infer	infer	VERB
gs-3799	636	22	team	team	NOUN
gs-3799	636	23	stress	stress	NOUN
gs-3799	636	24	levels	level	NOUN
gs-3799	636	25	and	and	CCONJ
gs-3799	636	26	modulate	modulate	VERB
gs-3799	636	27	alert	alert	NOUN
gs-3799	636	28	thresholds	threshold	NOUN
gs-3799	636	29	accordingly	accordingly	ADV
gs-3799	636	30	.	.	PUNCT
gs-3799	637	1	if	if	SCONJ
gs-3799	637	2	a	a	DET
gs-3799	637	3	perfusionist	perfusionist	NOUN
gs-3799	637	4	shows	show	VERB
gs-3799	637	5	signs	sign	NOUN
gs-3799	637	6	of	of	ADP
gs-3799	637	7	cognitive	cognitive	ADJ
gs-3799	637	8	overload	overload	NOUN
gs-3799	637	9	(	(	PUNCT
gs-3799	637	10	e.g.	e.g.	ADV
gs-3799	637	11	,	,	PUNCT
gs-3799	637	12	erratic	erratic	ADJ
gs-3799	637	13	inputs	input	NOUN
gs-3799	637	14	,	,	PUNCT
gs-3799	637	15	delayed	delay	VERB
gs-3799	637	16	reaction	reaction	NOUN
gs-3799	637	17	times	time	NOUN
gs-3799	637	18	)	)	PUNCT
gs-3799	637	19	,	,	PUNCT
gs-3799	637	20	the	the	DET
gs-3799	637	21	system	system	NOUN
gs-3799	637	22	can	can	AUX
gs-3799	637	23	switch	switch	VERB
gs-3799	637	24	to	to	ADP
gs-3799	637	25	a	a	DET
gs-3799	637	26	high	high	ADJ
gs-3799	637	27	-	-	PUNCT
gs-3799	637	28	autonomy	autonomy	NOUN
gs-3799	637	29	mode	mode	NOUN
gs-3799	637	30	,	,	PUNCT
gs-3799	637	31	reducing	reduce	VERB
gs-3799	637	32	the	the	DET
gs-3799	637	33	need	need	NOUN
gs-3799	637	34	for	for	ADP
gs-3799	637	35	manual	manual	ADJ
gs-3799	637	36	intervention	intervention	NOUN
gs-3799	637	37	.	.	PUNCT
gs-3799	638	1	this	this	DET
gs-3799	638	2	responsiveness	responsiveness	NOUN
gs-3799	638	3	represents	represent	VERB
gs-3799	638	4	an	an	DET
gs-3799	638	5	emergent	emergent	ADJ
gs-3799	638	6	affective	affective	NOUN
gs-3799	638	7	feedback	feedback	NOUN
gs-3799	638	8	loop	loop	NOUN
gs-3799	638	9	,	,	PUNCT
gs-3799	638	10	where	where	SCONJ
gs-3799	638	11	machines	machine	NOUN
gs-3799	638	12	not	not	PART
gs-3799	638	13	only	only	ADV
gs-3799	638	14	interact	interact	VERB
gs-3799	638	15	with	with	ADP
gs-3799	638	16	physiology	physiology	NOUN
gs-3799	638	17	but	but	CCONJ
gs-3799	638	18	adapt	adapt	VERB
gs-3799	638	19	to	to	ADP
gs-3799	638	20	the	the	DET
gs-3799	638	21	psychology	psychology	NOUN
gs-3799	638	22	of	of	ADP
gs-3799	638	23	the	the	DET
gs-3799	638	24	human	human	ADJ
gs-3799	638	25	operators	operator	NOUN
gs-3799	638	26	.	.	PUNCT
gs-3799	639	1	although	although	SCONJ
gs-3799	639	2	early	early	ADV
gs-3799	639	3	in	in	ADP
gs-3799	639	4	development	development	NOUN
gs-3799	639	5	,	,	PUNCT
gs-3799	639	6	this	this	DET
gs-3799	639	7	field	field	NOUN
gs-3799	639	8	may	may	AUX
gs-3799	639	9	hold	hold	VERB
gs-3799	639	10	keys	key	NOUN
gs-3799	639	11	to	to	PART
gs-3799	639	12	safer	safe	ADJ
gs-3799	639	13	navigation	navigation	NOUN
gs-3799	639	14	of	of	ADP
gs-3799	639	15	high	high	ADJ
gs-3799	639	16	-	-	PUNCT
gs-3799	639	17	stress	stress	NOUN
gs-3799	639	18	surgical	surgical	ADJ
gs-3799	639	19	environments	environment	NOUN
gs-3799	639	20	.	.	PUNCT
gs-3799	640	1	in	in	ADP
gs-3799	640	2	this	this	DET
gs-3799	640	3	newest	new	ADJ
gs-3799	640	4	wave	wave	NOUN
gs-3799	640	5	of	of	ADP
gs-3799	640	6	innovation	innovation	NOUN
gs-3799	640	7	,	,	PUNCT
gs-3799	640	8	closed	closed	ADJ
gs-3799	640	9	-	-	PUNCT
gs-3799	640	10	loop	loop	NOUN
gs-3799	640	11	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	640	12	bypass	bypass	NOUN
gs-3799	640	13	systems	system	NOUN
gs-3799	640	14	evolve	evolve	VERB
gs-3799	640	15	not	not	PART
gs-3799	640	16	just	just	ADV
gs-3799	640	17	toward	toward	ADP
gs-3799	640	18	more	more	ADV
gs-3799	640	19	precise	precise	ADJ
gs-3799	640	20	control	control	NOUN
gs-3799	640	21	,	,	PUNCT
gs-3799	640	22	but	but	CCONJ
gs-3799	640	23	toward	toward	ADP
gs-3799	640	24	systems	system	NOUN
gs-3799	640	25	capable	capable	ADJ
gs-3799	640	26	of	of	ADP
gs-3799	640	27	meta	meta	ADJ
gs-3799	640	28	-	-	PUNCT
gs-3799	640	29	cognition	cognition	NOUN
gs-3799	640	30	,	,	PUNCT
gs-3799	640	31	ethical	ethical	ADJ
gs-3799	640	32	arbitration	arbitration	NOUN
gs-3799	640	33	,	,	PUNCT
gs-3799	640	34	multiorgan	multiorgan	NOUN
gs-3799	640	35	dialogue	dialogue	NOUN
gs-3799	640	36	,	,	PUNCT
gs-3799	640	37	and	and	CCONJ
gs-3799	640	38	environmental	environmental	ADJ
gs-3799	640	39	adaptation	adaptation	NOUN
gs-3799	640	40	.	.	PUNCT
gs-3799	641	1	as	as	SCONJ
gs-3799	641	2	such	such	ADJ
gs-3799	641	3	,	,	PUNCT
gs-3799	641	4	cl	cl	NOUN
gs-3799	641	5	-	-	PUNCT
gs-3799	641	6	cpb	cpb	NOUN
gs-3799	641	7	is	be	AUX
gs-3799	641	8	no	no	ADV
gs-3799	641	9	longer	long	ADV
gs-3799	641	10	a	a	DET
gs-3799	641	11	passive	passive	ADJ
gs-3799	641	12	automation	automation	NOUN
gs-3799	641	13	but	but	CCONJ
gs-3799	641	14	a	a	DET
gs-3799	641	15	synthetic	synthetic	ADJ
gs-3799	641	16	physiological	physiological	ADJ
gs-3799	641	17	partner	partner	NOUN
gs-3799	641	18	—	—	PUNCT
gs-3799	641	19	an	an	DET
gs-3799	641	20	entity	entity	NOUN
gs-3799	641	21	that	that	PRON
gs-3799	641	22	interprets	interpret	VERB
gs-3799	641	23	,	,	PUNCT
gs-3799	641	24	predicts	predict	NOUN
gs-3799	641	25	,	,	PUNCT
gs-3799	641	26	negotiates	negotiate	NOUN
gs-3799	641	27	,	,	PUNCT
gs-3799	641	28	and	and	CCONJ
gs-3799	641	29	protects	protect	VERB
gs-3799	641	30	within	within	ADP
gs-3799	641	31	the	the	DET
gs-3799	641	32	chaotic	chaotic	ADJ
gs-3799	641	33	context	context	NOUN
gs-3799	641	34	of	of	ADP
gs-3799	641	35	high	high	ADJ
gs-3799	641	36	-	-	PUNCT
gs-3799	641	37	risk	risk	NOUN
gs-3799	641	38	surgery	surgery	NOUN
gs-3799	641	39	.	.	PUNCT
gs-3799	642	1	by	by	ADP
gs-3799	642	2	integrating	integrate	VERB
gs-3799	642	3	the	the	DET
gs-3799	642	4	sciences	science	NOUN
gs-3799	642	5	of	of	ADP
gs-3799	642	6	complexity	complexity	NOUN
gs-3799	642	7	,	,	PUNCT
gs-3799	642	8	neuroethics	neuroethic	NOUN
gs-3799	642	9	,	,	PUNCT
gs-3799	642	10	systems	system	NOUN
gs-3799	642	11	biology	biology	NOUN
gs-3799	642	12	,	,	PUNCT
gs-3799	642	13	and	and	CCONJ
gs-3799	642	14	ai	ai	VERB
gs-3799	642	15	logic	logic	NOUN
gs-3799	642	16	,	,	PUNCT
gs-3799	642	17	the	the	DET
gs-3799	642	18	future	future	NOUN
gs-3799	642	19	of	of	ADP
gs-3799	642	20	closed	closed	ADJ
gs-3799	642	21	-	-	PUNCT
gs-3799	642	22	loop	loop	NOUN
gs-3799	642	23	cpb	cpb	NOUN
gs-3799	642	24	is	be	AUX
gs-3799	642	25	poised	poise	VERB
gs-3799	642	26	not	not	PART
gs-3799	642	27	just	just	ADV
gs-3799	642	28	to	to	PART
gs-3799	642	29	change	change	VERB
gs-3799	642	30	practice	practice	NOUN
gs-3799	642	31	,	,	PUNCT
gs-3799	642	32	but	but	CCONJ
gs-3799	642	33	to	to	PART
gs-3799	642	34	redefine	redefine	VERB
gs-3799	642	35	what	what	PRON
gs-3799	642	36	we	we	PRON
gs-3799	642	37	understand	understand	VERB
gs-3799	642	38	as	as	ADP
gs-3799	642	39	intelligent	intelligent	ADJ
gs-3799	642	40	care	care	NOUN
gs-3799	642	41	.	.	PUNCT
gs-3799	643	1	the	the	DET
gs-3799	643	2	comprehensive	comprehensive	ADJ
gs-3799	643	3	analysis	analysis	NOUN
gs-3799	643	4	establishes	establish	VERB
gs-3799	643	5	that	that	SCONJ
gs-3799	643	6	closed	close	VERB
gs-3799	643	7	-	-	PUNCT
gs-3799	643	8	loop	loop	NOUN
gs-3799	643	9	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	643	10	bypass	bypass	NOUN
gs-3799	643	11	systems	system	NOUN
gs-3799	643	12	with	with	ADP
gs-3799	643	13	integrated	integrate	VERB
gs-3799	643	14	real	real	ADJ
gs-3799	643	15	-	-	PUNCT
gs-3799	643	16	time	time	NOUN
gs-3799	643	17	monitoring	monitoring	NOUN
gs-3799	643	18	and	and	CCONJ
gs-3799	643	19	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	643	20	represent	represent	VERB
gs-3799	643	21	a	a	DET
gs-3799	643	22	paradigm	paradigm	NOUN
gs-3799	643	23	shift	shift	NOUN
gs-3799	643	24	in	in	ADP
gs-3799	643	25	perfusion	perfusion	NOUN
gs-3799	643	26	technology	technology	NOUN
gs-3799	643	27	,	,	PUNCT
gs-3799	643	28	addressing	address	VERB
gs-3799	643	29	critical	critical	ADJ
gs-3799	643	30	limitations	limitation	NOUN
gs-3799	643	31	of	of	ADP
gs-3799	643	32	conventional	conventional	ADJ
gs-3799	643	33	cpb	cpb	PROPN
gs-3799	643	34	management	management	NOUN
gs-3799	643	35	.	.	PUNCT
gs-3799	644	1	by	by	ADP
gs-3799	644	2	synthesizing	synthesize	VERB
gs-3799	644	3	evidence	evidence	NOUN
gs-3799	644	4	across	across	ADP
gs-3799	644	5	technological	technological	ADJ
gs-3799	644	6	architectures	architecture	NOUN
gs-3799	644	7	,	,	PUNCT
gs-3799	644	8	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-3799	644	9	efficacy	efficacy	NOUN
gs-3799	644	10	,	,	PUNCT
gs-3799	644	11	clinical	clinical	ADJ
gs-3799	644	12	outcomes	outcome	NOUN
gs-3799	644	13	,	,	PUNCT
gs-3799	644	14	and	and	CCONJ
gs-3799	644	15	innovation	innovation	NOUN
gs-3799	644	16	impacts	impact	NOUN
gs-3799	644	17	,	,	PUNCT
gs-3799	644	18	this	this	DET
gs-3799	644	19	research	research	NOUN
gs-3799	644	20	demonstrates	demonstrate	VERB
gs-3799	644	21	that	that	SCONJ
gs-3799	644	22	closed	close	VERB
gs-3799	644	23	-	-	PUNCT
gs-3799	644	24	loop	loop	NOUN
gs-3799	644	25	systems	system	NOUN
gs-3799	644	26	significantly	significantly	ADV
gs-3799	644	27	enhance	enhance	VERB
gs-3799	644	28	hemodynamic	hemodynamic	ADJ
gs-3799	644	29	stability	stability	NOUN
gs-3799	644	30	,	,	PUNCT
gs-3799	644	31	reduce	reduce	VERB
gs-3799	644	32	human	human	ADJ
gs-3799	644	33	error	error	NOUN
gs-3799	644	34	,	,	PUNCT
gs-3799	644	35	and	and	CCONJ
gs-3799	644	36	optimize	optimize	VERB
gs-3799	644	37	therapeutic	therapeutic	ADJ
gs-3799	644	38	precision	precision	NOUN
gs-3799	644	39	—	—	PUNCT
gs-3799	644	40	particularly	particularly	ADV
gs-3799	644	41	in	in	ADP
gs-3799	644	42	anticoagulation	anticoagulation	NOUN
gs-3799	644	43	management	management	NOUN
gs-3799	644	44	—	—	PUNCT
gs-3799	644	45	through	through	ADP
gs-3799	644	46	continuous	continuous	ADJ
gs-3799	644	47	physiological	physiological	ADJ
gs-3799	644	48	feedback	feedback	NOUN
gs-3799	644	49	and	and	CCONJ
gs-3799	644	50	algorithmic	algorithmic	ADJ
gs-3799	644	51	control	control	NOUN
gs-3799	644	52	.	.	PUNCT
gs-3799	645	1	the	the	DET
gs-3799	645	2	integration	integration	NOUN
gs-3799	645	3	of	of	ADP
gs-3799	645	4	advanced	advanced	ADJ
gs-3799	645	5	sensors	sensor	NOUN
gs-3799	645	6	,	,	PUNCT
gs-3799	645	7	artificial	artificial	ADJ
gs-3799	645	8	intelligence	intelligence	NOUN
gs-3799	645	9	-	-	PUNCT
gs-3799	645	10	driven	drive	VERB
gs-3799	645	11	predictive	predictive	ADJ
gs-3799	645	12	analytics	analytic	NOUN
gs-3799	645	13	,	,	PUNCT
gs-3799	645	14	and	and	CCONJ
gs-3799	645	15	automated	automate	VERB
gs-3799	645	16	drug	drug	NOUN
gs-3799	645	17	delivery	delivery	NOUN
gs-3799	645	18	protocols	protocol	NOUN
gs-3799	645	19	enables	enable	VERB
gs-3799	645	20	proactive	proactive	ADJ
gs-3799	645	21	intervention	intervention	NOUN
gs-3799	645	22	,	,	PUNCT
gs-3799	645	23	mitigating	mitigate	VERB
gs-3799	645	24	risks	risk	NOUN
gs-3799	645	25	of	of	ADP
gs-3799	645	26	thrombosis	thrombosis	NOUN
gs-3799	645	27	,	,	PUNCT
gs-3799	645	28	hemorrhage	hemorrhage	NOUN
gs-3799	645	29	,	,	PUNCT
gs-3799	645	30	and	and	CCONJ
gs-3799	645	31	end	end	NOUN
gs-3799	645	32	-	-	PUNCT
gs-3799	645	33	organ	organ	NOUN
gs-3799	645	34	injury	injury	NOUN
gs-3799	645	35	while	while	SCONJ
gs-3799	645	36	alleviating	alleviate	VERB
gs-3799	645	37	cognitive	cognitive	ADJ
gs-3799	645	38	burdens	burden	NOUN
gs-3799	645	39	on	on	ADP
gs-3799	645	40	perfusionists	perfusionist	NOUN
gs-3799	645	41	.	.	PUNCT
gs-3799	646	1	nevertheless	nevertheless	ADV
gs-3799	646	2	,	,	PUNCT
gs-3799	646	3	the	the	DET
gs-3799	646	4	field	field	NOUN
gs-3799	646	5	faces	face	VERB
gs-3799	646	6	persistent	persistent	ADJ
gs-3799	646	7	challenges	challenge	NOUN
gs-3799	646	8	.	.	PUNCT
gs-3799	647	1	evidence	evidence	NOUN
gs-3799	647	2	remains	remain	VERB
gs-3799	647	3	fragmented	fragmented	ADJ
gs-3799	647	4	across	across	ADP
gs-3799	647	5	proprietary	proprietary	ADJ
gs-3799	647	6	systems	system	NOUN
gs-3799	647	7	,	,	PUNCT
gs-3799	647	8	with	with	ADP
gs-3799	647	9	limited	limited	ADJ
gs-3799	647	10	large	large	ADJ
gs-3799	647	11	-	-	PUNCT
gs-3799	647	12	scale	scale	NOUN
gs-3799	647	13	randomized	randomized	ADJ
gs-3799	647	14	trials	trial	NOUN
gs-3799	647	15	validating	validate	VERB
gs-3799	647	16	hard	hard	ADJ
gs-3799	647	17	clinical	clinical	ADJ
gs-3799	647	18	endpoints	endpoint	NOUN
gs-3799	647	19	such	such	ADJ
gs-3799	647	20	as	as	ADP
gs-3799	647	21	mortality	mortality	NOUN
gs-3799	647	22	or	or	CCONJ
gs-3799	647	23	neurocognitive	neurocognitive	ADJ
gs-3799	647	24	outcomes	outcome	NOUN
gs-3799	647	25	.	.	PUNCT
gs-3799	648	1	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	648	2	integration	integration	NOUN
gs-3799	648	3	beyond	beyond	ADP
gs-3799	648	4	anticoagulation	anticoagulation	NOUN
gs-3799	648	5	—	—	PUNCT
gs-3799	648	6	notably	notably	ADV
gs-3799	648	7	vasoactive	vasoactive	ADJ
gs-3799	648	8	agents	agent	NOUN
gs-3799	648	9	and	and	CCONJ
gs-3799	648	10	anti	anti	ADJ
gs-3799	648	11	-	-	ADJ
gs-3799	648	12	inflammatory	inflammatory	ADJ
gs-3799	648	13	strategies	strategy	NOUN
gs-3799	648	14	—	—	PUNCT
gs-3799	648	15	requires	require	VERB
gs-3799	648	16	further	further	ADJ
gs-3799	648	17	validation	validation	NOUN
gs-3799	648	18	,	,	PUNCT
gs-3799	648	19	while	while	SCONJ
gs-3799	648	20	interoperability	interoperability	NOUN
gs-3799	648	21	standards	standard	NOUN
gs-3799	648	22	and	and	CCONJ
gs-3799	648	23	cybersecurity	cybersecurity	NOUN
gs-3799	648	24	frameworks	framework	NOUN
gs-3799	648	25	for	for	ADP
gs-3799	648	26	multi	multi	ADJ
gs-3799	648	27	-	-	ADJ
gs-3799	648	28	vendor	vendor	ADJ
gs-3799	648	29	environments	environment	NOUN
gs-3799	648	30	remain	remain	VERB
gs-3799	648	31	underdeveloped	underdeveloped	ADJ
gs-3799	648	32	.	.	PUNCT
gs-3799	649	1	human	human	ADJ
gs-3799	649	2	factors	factor	NOUN
gs-3799	649	3	,	,	PUNCT
gs-3799	649	4	including	include	VERB
gs-3799	649	5	perfusionist	perfusionist	NOUN
gs-3799	649	6	training	training	NOUN
gs-3799	649	7	for	for	ADP
gs-3799	649	8	supervisory	supervisory	ADJ
gs-3799	649	9	roles	role	NOUN
gs-3799	649	10	and	and	CCONJ
gs-3799	649	11	adaptive	adaptive	ADJ
gs-3799	649	12	automation	automation	NOUN
gs-3799	649	13	interfaces	interface	NOUN
gs-3799	649	14	,	,	PUNCT
gs-3799	649	15	demand	demand	NOUN
gs-3799	649	16	deliberate	deliberate	ADJ
gs-3799	649	17	redesign	redesign	NOUN
gs-3799	649	18	to	to	PART
gs-3799	649	19	ensure	ensure	VERB
gs-3799	649	20	safe	safe	ADJ
gs-3799	649	21	adoption	adoption	NOUN
gs-3799	649	22	.	.	PUNCT
gs-3799	650	1	georgian	georgian	NOUN
gs-3799	650	2	scientists/	scientists/	NUM
gs-3799	650	3	.	.	PUNCT
gs-3799	651	1	7	7	NUM
gs-3799	651	2	n	n	PRON
gs-3799	651	3	2	2	NUM
gs-3799	651	4	,	,	PUNCT
gs-3799	651	5	2025	2025	NUM
gs-3799	651	6	412	412	NUM
gs-3799	651	7	future	future	ADJ
gs-3799	651	8	perspectives	perspective	NOUN
gs-3799	651	9	the	the	DET
gs-3799	651	10	future	future	NOUN
gs-3799	651	11	of	of	ADP
gs-3799	651	12	closed	closed	ADJ
gs-3799	651	13	-	-	PUNCT
gs-3799	651	14	loop	loop	NOUN
gs-3799	651	15	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	651	16	bypass	bypass	NOUN
gs-3799	651	17	(	(	PUNCT
gs-3799	651	18	cpb	cpb	NOUN
gs-3799	651	19	)	)	PUNCT
gs-3799	651	20	systems	system	NOUN
gs-3799	651	21	in	in	ADP
gs-3799	651	22	pediatric	pediatric	ADJ
gs-3799	651	23	cardiac	cardiac	ADJ
gs-3799	651	24	surgery	surgery	NOUN
gs-3799	651	25	is	be	AUX
gs-3799	651	26	truly	truly	ADV
gs-3799	651	27	encouraging	encouraging	ADJ
gs-3799	651	28	,	,	PUNCT
gs-3799	651	29	as	as	SCONJ
gs-3799	651	30	developments	development	NOUN
gs-3799	651	31	in	in	ADP
gs-3799	651	32	biomedical	biomedical	ADJ
gs-3799	651	33	engineering	engineering	NOUN
gs-3799	651	34	,	,	PUNCT
gs-3799	651	35	sensor	sensor	NOUN
gs-3799	651	36	technology	technology	NOUN
gs-3799	651	37	,	,	PUNCT
gs-3799	651	38	and	and	CCONJ
gs-3799	651	39	artificial	artificial	ADJ
gs-3799	651	40	intelligence	intelligence	NOUN
gs-3799	651	41	(	(	PUNCT
gs-3799	651	42	ai	ai	AUX
gs-3799	651	43	)	)	PUNCT
gs-3799	651	44	continue	continue	VERB
gs-3799	651	45	to	to	PART
gs-3799	651	46	intersect	intersect	VERB
gs-3799	651	47	.	.	PUNCT
gs-3799	652	1	it	it	PRON
gs-3799	652	2	is	be	AUX
gs-3799	652	3	predicted	predict	VERB
gs-3799	652	4	that	that	SCONJ
gs-3799	652	5	the	the	DET
gs-3799	652	6	next	next	ADJ
gs-3799	652	7	-	-	PUNCT
gs-3799	652	8	generation	generation	NOUN
gs-3799	652	9	systems	system	NOUN
gs-3799	652	10	will	will	AUX
gs-3799	652	11	involve	involve	VERB
gs-3799	652	12	the	the	DET
gs-3799	652	13	use	use	NOUN
gs-3799	652	14	of	of	ADP
gs-3799	652	15	multi	multi	ADJ
gs-3799	652	16	-	-	ADJ
gs-3799	652	17	parametric	parametric	ADJ
gs-3799	652	18	data	datum	NOUN
gs-3799	652	19	systems	system	NOUN
gs-3799	652	20	from	from	ADP
gs-3799	652	21	next	next	ADJ
gs-3799	652	22	level	level	NOUN
gs-3799	652	23	,	,	PUNCT
gs-3799	652	24	miniaturized	miniaturize	VERB
gs-3799	652	25	sensors	sensor	NOUN
gs-3799	652	26	which	which	PRON
gs-3799	652	27	have	have	VERB
gs-3799	652	28	the	the	DET
gs-3799	652	29	ability	ability	NOUN
gs-3799	652	30	of	of	ADP
gs-3799	652	31	non	non	ADJ
gs-3799	652	32	-	-	ADJ
gs-3799	652	33	invasively	invasively	ADV
gs-3799	652	34	measuring	measure	VERB
gs-3799	652	35	changes	change	NOUN
gs-3799	652	36	such	such	ADJ
gs-3799	652	37	as	as	ADP
gs-3799	652	38	cerebral	cerebral	ADJ
gs-3799	652	39	oxygen	oxygen	NOUN
gs-3799	652	40	saturation	saturation	NOUN
gs-3799	652	41	,	,	PUNCT
gs-3799	652	42	cardiac	cardiac	ADJ
gs-3799	652	43	output	output	NOUN
gs-3799	652	44	,	,	PUNCT
gs-3799	652	45	systemic	systemic	ADJ
gs-3799	652	46	vascular	vascular	ADJ
gs-3799	652	47	resistance	resistance	NOUN
gs-3799	652	48	,	,	PUNCT
gs-3799	652	49	and	and	CCONJ
gs-3799	652	50	metabolic	metabolic	NOUN
gs-3799	652	51	markers	marker	NOUN
gs-3799	652	52	in	in	ADP
gs-3799	652	53	real	real	ADJ
gs-3799	652	54	conditions	condition	NOUN
gs-3799	652	55	and	and	CCONJ
gs-3799	652	56	time	time	NOUN
gs-3799	652	57	.	.	PUNCT
gs-3799	653	1	these	these	DET
gs-3799	653	2	transformations	transformation	NOUN
gs-3799	653	3	will	will	AUX
gs-3799	653	4	enable	enable	VERB
gs-3799	653	5	for	for	ADP
gs-3799	653	6	extensive	extensive	ADJ
gs-3799	653	7	physiological	physiological	ADJ
gs-3799	653	8	perception	perception	NOUN
gs-3799	653	9	and	and	CCONJ
gs-3799	653	10	more	more	ADV
gs-3799	653	11	accurate	accurate	ADJ
gs-3799	653	12	maintenance	maintenance	NOUN
gs-3799	653	13	during	during	ADP
gs-3799	653	14	surgery	surgery	NOUN
gs-3799	653	15	.	.	PUNCT
gs-3799	654	1	a	a	DET
gs-3799	654	2	combination	combination	NOUN
gs-3799	654	3	of	of	ADP
gs-3799	654	4	machine	machine	NOUN
gs-3799	654	5	learning	learning	NOUN
gs-3799	654	6	procedures	procedure	NOUN
gs-3799	654	7	coached	coach	VERB
gs-3799	654	8	on	on	ADP
gs-3799	654	9	huge	huge	ADJ
gs-3799	654	10	sets	set	NOUN
gs-3799	654	11	of	of	ADP
gs-3799	654	12	values	value	NOUN
gs-3799	654	13	in	in	ADP
gs-3799	654	14	pediatric	pediatric	ADJ
gs-3799	654	15	surgical	surgical	ADJ
gs-3799	654	16	cases	case	NOUN
gs-3799	654	17	is	be	AUX
gs-3799	654	18	likely	likely	ADJ
gs-3799	654	19	to	to	PART
gs-3799	654	20	allow	allow	VERB
gs-3799	654	21	flexible	flexible	ADJ
gs-3799	654	22	decision	decision	NOUN
gs-3799	654	23	-	-	PUNCT
gs-3799	654	24	making	make	VERB
gs-3799	654	25	models	model	NOUN
gs-3799	654	26	that	that	PRON
gs-3799	654	27	improve	improve	VERB
gs-3799	654	28	with	with	ADP
gs-3799	654	29	continued	continued	ADJ
gs-3799	654	30	use	use	NOUN
gs-3799	654	31	.	.	PUNCT
gs-3799	655	1	these	these	DET
gs-3799	655	2	valued	value	VERB
gs-3799	655	3	data	datum	NOUN
gs-3799	655	4	of	of	ADP
gs-3799	655	5	personalization	personalization	NOUN
gs-3799	655	6	may	may	AUX
gs-3799	655	7	allow	allow	VERB
gs-3799	655	8	for	for	ADP
gs-3799	655	9	prognostic	prognostic	ADJ
gs-3799	655	10	perfusion	perfusion	NOUN
gs-3799	655	11	methods	method	NOUN
gs-3799	655	12	that	that	PRON
gs-3799	655	13	proactively	proactively	ADV
gs-3799	655	14	modify	modify	VERB
gs-3799	655	15	parameters	parameter	NOUN
gs-3799	655	16	based	base	VERB
gs-3799	655	17	on	on	ADP
gs-3799	655	18	well	well	ADV
gs-3799	655	19	predicted	predict	VERB
gs-3799	655	20	physiological	physiological	ADJ
gs-3799	655	21	variations	variation	NOUN
gs-3799	655	22	.	.	PUNCT
gs-3799	656	1	more	more	ADV
gs-3799	656	2	over	over	ADP
gs-3799	656	3	cloud	cloud	NOUN
gs-3799	656	4	-	-	PUNCT
gs-3799	656	5	based	base	VERB
gs-3799	656	6	programs	program	NOUN
gs-3799	656	7	could	could	AUX
gs-3799	656	8	allow	allow	VERB
gs-3799	656	9	intraoperative	intraoperative	ADJ
gs-3799	656	10	data	datum	NOUN
gs-3799	656	11	to	to	PART
gs-3799	656	12	be	be	AUX
gs-3799	656	13	kept	keep	VERB
gs-3799	656	14	,	,	PUNCT
gs-3799	656	15	assesed	assese	VERB
gs-3799	656	16	retrospectively	retrospectively	ADV
gs-3799	656	17	,	,	PUNCT
gs-3799	656	18	and	and	CCONJ
gs-3799	656	19	used	use	VERB
gs-3799	656	20	for	for	ADP
gs-3799	656	21	continuous	continuous	ADJ
gs-3799	656	22	technique	technique	NOUN
gs-3799	656	23	refinement	refinement	NOUN
gs-3799	656	24	across	across	ADP
gs-3799	656	25	institutions	institution	NOUN
gs-3799	656	26	.	.	PUNCT
gs-3799	657	1	robotic	robotic	ADJ
gs-3799	657	2	incorporation	incorporation	NOUN
gs-3799	657	3	and	and	CCONJ
gs-3799	657	4	clever	clever	ADJ
gs-3799	657	5	catalyst	catalyst	NOUN
gs-3799	657	6	systems	system	NOUN
gs-3799	657	7	may	may	AUX
gs-3799	657	8	also	also	ADV
gs-3799	657	9	develop	develop	VERB
gs-3799	657	10	,	,	PUNCT
gs-3799	657	11	the	the	DET
gs-3799	657	12	closed	closed	ADJ
gs-3799	657	13	-	-	PUNCT
gs-3799	657	14	loop	loop	NOUN
gs-3799	657	15	cpb	cpb	NOUN
gs-3799	657	16	system	system	NOUN
gs-3799	657	17	communicates	communicate	VERB
gs-3799	657	18	straight	straight	ADJ
gs-3799	657	19	with	with	ADP
gs-3799	657	20	robotic	robotic	ADJ
gs-3799	657	21	-	-	PUNCT
gs-3799	657	22	assisted	assist	VERB
gs-3799	657	23	surgical	surgical	ADJ
gs-3799	657	24	instruments	instrument	NOUN
gs-3799	657	25	to	to	PART
gs-3799	657	26	correlate	correlate	VERB
gs-3799	657	27	perfusion	perfusion	NOUN
gs-3799	657	28	with	with	ADP
gs-3799	657	29	surgical	surgical	ADJ
gs-3799	657	30	steps	step	NOUN
gs-3799	657	31	.	.	PUNCT
gs-3799	658	1	furthermore	furthermore	ADV
gs-3799	658	2	,	,	PUNCT
gs-3799	658	3	growth	growth	NOUN
gs-3799	658	4	of	of	ADP
gs-3799	658	5	minimally	minimally	ADV
gs-3799	658	6	invasive	invasive	ADJ
gs-3799	658	7	or	or	CCONJ
gs-3799	658	8	out	out	ADP
gs-3799	658	9	of	of	ADP
gs-3799	658	10	body	body	NOUN
gs-3799	658	11	mini	mini	NOUN
gs-3799	658	12	-	-	PROPN
gs-3799	658	13	cpb	cpb	ADJ
gs-3799	658	14	systems	system	NOUN
gs-3799	658	15	customized	customize	VERB
gs-3799	658	16	for	for	ADP
gs-3799	658	17	neonates	neonate	NOUN
gs-3799	658	18	could	could	AUX
gs-3799	658	19	lead	lead	VERB
gs-3799	658	20	to	to	ADP
gs-3799	658	21	positive	positive	ADJ
gs-3799	658	22	outcomes	outcome	NOUN
gs-3799	658	23	in	in	ADP
gs-3799	658	24	multiplex	multiplex	PROPN
gs-3799	658	25	or	or	CCONJ
gs-3799	658	26	high	high	ADJ
gs-3799	658	27	-	-	PUNCT
gs-3799	658	28	risk	risk	NOUN
gs-3799	658	29	procedures	procedure	NOUN
gs-3799	658	30	.	.	PUNCT
gs-3799	659	1	ethical	ethical	ADJ
gs-3799	659	2	schemes	scheme	NOUN
gs-3799	659	3	and	and	CCONJ
gs-3799	659	4	human	human	ADJ
gs-3799	659	5	-	-	PUNCT
gs-3799	659	6	machine	machine	NOUN
gs-3799	659	7	alliance	alliance	NOUN
gs-3799	659	8	models	model	NOUN
gs-3799	659	9	will	will	AUX
gs-3799	659	10	also	also	ADV
gs-3799	659	11	play	play	VERB
gs-3799	659	12	a	a	DET
gs-3799	659	13	pivotal	pivotal	ADJ
gs-3799	659	14	role	role	NOUN
gs-3799	659	15	in	in	ADP
gs-3799	659	16	deciding	decide	VERB
gs-3799	659	17	how	how	SCONJ
gs-3799	659	18	mechanization	mechanization	NOUN
gs-3799	659	19	can	can	AUX
gs-3799	659	20	be	be	AUX
gs-3799	659	21	well	well	ADV
gs-3799	659	22	stabilized	stabilize	VERB
gs-3799	659	23	with	with	ADP
gs-3799	659	24	clinical	clinical	ADJ
gs-3799	659	25	sense	sense	NOUN
gs-3799	659	26	to	to	PART
gs-3799	659	27	optimize	optimize	VERB
gs-3799	659	28	safety	safety	NOUN
gs-3799	659	29	and	and	CCONJ
gs-3799	659	30	effectiveness	effectiveness	NOUN
gs-3799	659	31	.	.	PUNCT
gs-3799	660	1	eventually	eventually	ADV
gs-3799	660	2	,	,	PUNCT
gs-3799	660	3	interdisciplinary	interdisciplinary	ADJ
gs-3799	660	4	cooperation	cooperation	NOUN
gs-3799	660	5	between	between	ADP
gs-3799	660	6	clinicians	clinician	NOUN
gs-3799	660	7	,	,	PUNCT
gs-3799	660	8	biomedical	biomedical	ADJ
gs-3799	660	9	engineers	engineer	NOUN
gs-3799	660	10	,	,	PUNCT
gs-3799	660	11	computer	computer	NOUN
gs-3799	660	12	scientists	scientist	NOUN
gs-3799	660	13	,	,	PUNCT
gs-3799	660	14	and	and	CCONJ
gs-3799	660	15	regulatory	regulatory	ADJ
gs-3799	660	16	bodies	body	NOUN
gs-3799	660	17	will	will	AUX
gs-3799	660	18	be	be	AUX
gs-3799	660	19	key	key	ADJ
gs-3799	660	20	to	to	PART
gs-3799	660	21	move	move	VERB
gs-3799	660	22	forward	forward	ADV
gs-3799	660	23	from	from	ADP
gs-3799	660	24	prototype	prototype	NOUN
gs-3799	660	25	systems	system	NOUN
gs-3799	660	26	to	to	ADP
gs-3799	660	27	extensive	extensive	ADJ
gs-3799	660	28	clinical	clinical	ADJ
gs-3799	660	29	application	application	NOUN
gs-3799	660	30	.	.	PUNCT
gs-3799	661	1	the	the	DET
gs-3799	661	2	probable	probable	ADJ
gs-3799	661	3	benefits	benefit	NOUN
gs-3799	661	4	of	of	ADP
gs-3799	661	5	these	these	DET
gs-3799	661	6	systems	system	NOUN
gs-3799	661	7	—	—	PUNCT
gs-3799	661	8	decreased	decrease	VERB
gs-3799	661	9	difficulty	difficulty	NOUN
gs-3799	661	10	and	and	CCONJ
gs-3799	661	11	compilation	compilation	NOUN
gs-3799	661	12	rates	rate	NOUN
gs-3799	661	13	,	,	PUNCT
gs-3799	661	14	enhanced	enhance	VERB
gs-3799	661	15	neurological	neurological	ADJ
gs-3799	661	16	results	result	NOUN
gs-3799	661	17	,	,	PUNCT
gs-3799	661	18	and	and	CCONJ
gs-3799	661	19	smooth	smooth	ADJ
gs-3799	661	20	surgical	surgical	ADJ
gs-3799	661	21	workflows	workflow	NOUN
gs-3799	661	22	—	—	PUNCT
gs-3799	661	23	make	make	VERB
gs-3799	661	24	them	they	PRON
gs-3799	661	25	a	a	DET
gs-3799	661	26	precious	precious	ADJ
gs-3799	661	27	target	target	NOUN
gs-3799	661	28	for	for	ADP
gs-3799	661	29	ongoing	ongoing	ADJ
gs-3799	661	30	research	research	NOUN
gs-3799	661	31	and	and	CCONJ
gs-3799	661	32	growth	growth	NOUN
gs-3799	661	33	.	.	PUNCT
gs-3799	662	1	the	the	DET
gs-3799	662	2	evolution	evolution	NOUN
gs-3799	662	3	of	of	ADP
gs-3799	662	4	closed	closed	ADJ
gs-3799	662	5	-	-	PUNCT
gs-3799	662	6	loop	loop	NOUN
gs-3799	662	7	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	662	8	bypass	bypass	NOUN
gs-3799	662	9	(	(	PUNCT
gs-3799	662	10	cpb	cpb	NOUN
gs-3799	662	11	)	)	PUNCT
gs-3799	662	12	systems	system	NOUN
gs-3799	662	13	with	with	ADP
gs-3799	662	14	integrated	integrate	VERB
gs-3799	662	15	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	662	16	hinges	hinge	NOUN
gs-3799	662	17	on	on	ADP
gs-3799	662	18	transcending	transcend	VERB
gs-3799	662	19	current	current	ADJ
gs-3799	662	20	technological	technological	ADJ
gs-3799	662	21	and	and	CCONJ
gs-3799	662	22	evidence	evidence	NOUN
gs-3799	662	23	-	-	PUNCT
gs-3799	662	24	based	base	VERB
gs-3799	662	25	limitations	limitation	NOUN
gs-3799	662	26	.	.	PUNCT
gs-3799	663	1	to	to	PART
gs-3799	663	2	fully	fully	ADV
gs-3799	663	3	realize	realize	VERB
gs-3799	663	4	their	their	PRON
gs-3799	663	5	potential	potential	NOUN
gs-3799	663	6	in	in	ADP
gs-3799	663	7	revolutionizing	revolutionize	VERB
gs-3799	663	8	cardiac	cardiac	ADJ
gs-3799	663	9	surgery	surgery	NOUN
gs-3799	663	10	,	,	PUNCT
gs-3799	663	11	several	several	ADJ
gs-3799	663	12	interdependent	interdependent	ADJ
gs-3799	663	13	pathways	pathway	NOUN
gs-3799	663	14	demand	demand	NOUN
gs-3799	663	15	prioritized	prioritize	VERB
gs-3799	663	16	attention	attention	NOUN
gs-3799	663	17	.	.	PUNCT
gs-3799	664	1	foremost	foremost	ADV
gs-3799	664	2	,	,	PUNCT
gs-3799	664	3	the	the	DET
gs-3799	664	4	field	field	NOUN
gs-3799	664	5	requires	require	VERB
gs-3799	664	6	robust	robust	ADJ
gs-3799	664	7	clinical	clinical	ADJ
gs-3799	664	8	validation	validation	NOUN
gs-3799	664	9	through	through	ADP
gs-3799	664	10	largescale	largescale	NOUN
gs-3799	664	11	,	,	PUNCT
gs-3799	664	12	multicenter	multicenter	NOUN
gs-3799	664	13	randomized	randomize	VERB
gs-3799	664	14	trials	trial	NOUN
gs-3799	664	15	comparing	compare	VERB
gs-3799	664	16	comprehensive	comprehensive	ADJ
gs-3799	664	17	closed	close	VERB
gs-3799	664	18	-	-	PUNCT
gs-3799	664	19	loop	loop	NOUN
gs-3799	664	20	systems	system	NOUN
gs-3799	664	21	against	against	ADP
gs-3799	664	22	conventional	conventional	ADJ
gs-3799	664	23	cpb	cpb	NOUN
gs-3799	664	24	across	across	ADP
gs-3799	664	25	diverse	diverse	ADJ
gs-3799	664	26	patient	patient	ADJ
gs-3799	664	27	populations	population	NOUN
gs-3799	664	28	and	and	CCONJ
gs-3799	664	29	surgical	surgical	ADJ
gs-3799	664	30	contexts	contexts	NOUN
gs-3799	664	31	.	.	PUNCT
gs-3799	665	1	these	these	DET
gs-3799	665	2	studies	study	NOUN
gs-3799	665	3	must	must	AUX
gs-3799	665	4	evaluate	evaluate	VERB
gs-3799	665	5	not	not	PART
gs-3799	665	6	only	only	ADV
gs-3799	665	7	traditional	traditional	ADJ
gs-3799	665	8	endpoints	endpoint	NOUN
gs-3799	665	9	—	—	PUNCT
gs-3799	665	10	mortality	mortality	NOUN
gs-3799	665	11	,	,	PUNCT
gs-3799	665	12	stroke	stroke	NOUN
gs-3799	665	13	,	,	PUNCT
gs-3799	665	14	renal	renal	ADJ
gs-3799	665	15	injury	injury	NOUN
gs-3799	665	16	—	—	PUNCT
gs-3799	665	17	but	but	CCONJ
gs-3799	665	18	also	also	ADV
gs-3799	665	19	patient	patient	NOUN
gs-3799	665	20	-	-	PUNCT
gs-3799	665	21	centered	center	VERB
gs-3799	665	22	outcomes	outcome	NOUN
gs-3799	665	23	such	such	ADJ
gs-3799	665	24	as	as	ADP
gs-3799	665	25	neurocognitive	neurocognitive	ADJ
gs-3799	665	26	recovery	recovery	NOUN
gs-3799	665	27	and	and	CCONJ
gs-3799	665	28	long	long	ADJ
gs-3799	665	29	-	-	PUNCT
gs-3799	665	30	term	term	NOUN
gs-3799	665	31	functional	functional	ADJ
gs-3799	665	32	status	status	NOUN
gs-3799	665	33	,	,	PUNCT
gs-3799	665	34	alongside	alongside	ADP
gs-3799	665	35	rigorous	rigorous	ADJ
gs-3799	665	36	health	health	NOUN
gs-3799	665	37	economic	economic	ADJ
gs-3799	665	38	analyses	analysis	NOUN
gs-3799	665	39	.	.	PUNCT
gs-3799	666	1	parallel	parallel	ADJ
gs-3799	666	2	advancements	advancement	NOUN
gs-3799	666	3	in	in	ADP
gs-3799	666	4	biomarker	biomarker	NOUN
gs-3799	666	5	discovery	discovery	NOUN
gs-3799	666	6	should	should	AUX
gs-3799	666	7	enable	enable	VERB
gs-3799	666	8	real	real	ADJ
gs-3799	666	9	-	-	PUNCT
gs-3799	666	10	time	time	NOUN
gs-3799	666	11	personalization	personalization	NOUN
gs-3799	666	12	,	,	PUNCT
gs-3799	666	13	leveraging	leverage	VERB
gs-3799	666	14	dynamic	dynamic	ADJ
gs-3799	666	15	data	datum	NOUN
gs-3799	666	16	streams	stream	NOUN
gs-3799	666	17	from	from	ADP
gs-3799	666	18	inflammatory	inflammatory	ADJ
gs-3799	666	19	mediators	mediator	NOUN
gs-3799	666	20	(	(	PUNCT
gs-3799	666	21	e.g.	e.g.	ADV
gs-3799	666	22	,	,	PUNCT
gs-3799	666	23	il-6	il-6	NUM
gs-3799	666	24	,	,	PUNCT
gs-3799	666	25	tnf	tnf	PROPN
gs-3799	666	26	)	)	PUNCT
gs-3799	666	27	,	,	PUNCT
gs-3799	666	28	endothelial	endothelial	ADJ
gs-3799	666	29	glycocalyx	glycocalyx	PROPN
gs-3799	666	30	markers	marker	NOUN
gs-3799	666	31	(	(	PUNCT
gs-3799	666	32	syndecan-1	syndecan-1	NUM
gs-3799	666	33	)	)	PUNCT
gs-3799	666	34	,	,	PUNCT
gs-3799	666	35	and	and	CCONJ
gs-3799	666	36	organ	organ	NOUN
gs-3799	666	37	-	-	PUNCT
gs-3799	666	38	specific	specific	ADJ
gs-3799	666	39	injury	injury	NOUN
gs-3799	666	40	signals	signal	NOUN
gs-3799	666	41	(	(	PUNCT
gs-3799	666	42	ngal	ngal	ADJ
gs-3799	666	43	for	for	ADP
gs-3799	666	44	renal	renal	ADJ
gs-3799	666	45	protection	protection	NOUN
gs-3799	666	46	)	)	PUNCT
gs-3799	666	47	to	to	PART
gs-3799	666	48	tailor	tailor	VERB
gs-3799	666	49	perfusion	perfusion	NOUN
gs-3799	666	50	and	and	CCONJ
gs-3799	666	51	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	666	52	algorithms	algorithm	NOUN
gs-3799	666	53	to	to	ADP
gs-3799	666	54	individual	individual	ADJ
gs-3799	666	55	physiological	physiological	ADJ
gs-3799	666	56	phenotypes	phenotype	NOUN
gs-3799	666	57	.	.	PUNCT
gs-3799	667	1	technologically	technologically	ADV
gs-3799	667	2	,	,	PUNCT
gs-3799	667	3	the	the	DET
gs-3799	667	4	transition	transition	NOUN
gs-3799	667	5	from	from	ADP
gs-3799	667	6	reactive	reactive	ADJ
gs-3799	667	7	to	to	ADP
gs-3799	667	8	predictive	predictive	ADJ
gs-3799	667	9	systems	system	NOUN
gs-3799	667	10	represents	represent	VERB
gs-3799	667	11	the	the	DET
gs-3799	667	12	next	next	ADJ
gs-3799	667	13	frontier	frontier	NOUN
gs-3799	667	14	.	.	PUNCT
gs-3799	668	1	artificial	artificial	ADJ
gs-3799	668	2	intelligence	intelligence	NOUN
gs-3799	668	3	and	and	CCONJ
gs-3799	668	4	machine	machine	NOUN
gs-3799	668	5	learning	learning	NOUN
gs-3799	668	6	must	must	AUX
gs-3799	668	7	evolve	evolve	VERB
gs-3799	668	8	beyond	beyond	ADP
gs-3799	668	9	current	current	ADJ
gs-3799	668	10	control	control	NOUN
gs-3799	668	11	paradigms	paradigm	VERB
gs-3799	668	12	,	,	PUNCT
gs-3799	668	13	utilizing	utilize	VERB
gs-3799	668	14	federated	federated	ADJ
gs-3799	668	15	learning	learn	VERB
gs-3799	668	16	architectures	architecture	NOUN
gs-3799	668	17	trained	train	VERB
gs-3799	668	18	on	on	ADP
gs-3799	668	19	multi	multi	ADJ
gs-3799	668	20	-	-	ADJ
gs-3799	668	21	institutional	institutional	ADJ
gs-3799	668	22	datasets	dataset	NOUN
gs-3799	668	23	to	to	PART
gs-3799	668	24	forecast	forecast	VERB
gs-3799	668	25	coagulopathy	coagulopathy	ADJ
gs-3799	668	26	or	or	CCONJ
gs-3799	668	27	georgian	georgian	NOUN
gs-3799	668	28	scientists/	scientists/	NUM
gs-3799	668	29	.	.	PUNCT
gs-3799	669	1	7	7	NUM
gs-3799	669	2	n	n	DET
gs-3799	669	3	2	2	NUM
gs-3799	669	4	,	,	PUNCT
gs-3799	669	5	2025	2025	NUM
gs-3799	669	6	413	413	NUM
gs-3799	669	7	hemodynamic	hemodynamic	ADJ
gs-3799	669	8	instability	instability	NOUN
gs-3799	669	9	before	before	ADP
gs-3799	669	10	clinical	clinical	ADJ
gs-3799	669	11	manifestation	manifestation	NOUN
gs-3799	669	12	.	.	PUNCT
gs-3799	670	1	this	this	PRON
gs-3799	670	2	necessitates	necessitate	VERB
gs-3799	670	3	concurrent	concurrent	ADJ
gs-3799	670	4	development	development	NOUN
gs-3799	670	5	of	of	ADP
gs-3799	670	6	advanced	advanced	ADJ
gs-3799	670	7	sensor	sensor	NOUN
gs-3799	670	8	ecosystems	ecosystem	NOUN
gs-3799	670	9	—	—	PUNCT
gs-3799	670	10	including	include	VERB
gs-3799	670	11	miniaturized	miniaturize	VERB
gs-3799	670	12	implantable	implantable	ADJ
gs-3799	670	13	monitors	monitor	NOUN
gs-3799	670	14	for	for	ADP
gs-3799	670	15	endothelial	endothelial	ADJ
gs-3799	670	16	function	function	NOUN
gs-3799	670	17	,	,	PUNCT
gs-3799	670	18	self	self	NOUN
gs-3799	670	19	-	-	PUNCT
gs-3799	670	20	validating	validate	VERB
gs-3799	670	21	optical	optical	ADJ
gs-3799	670	22	sensors	sensor	NOUN
gs-3799	670	23	resistant	resistant	ADJ
gs-3799	670	24	to	to	ADP
gs-3799	670	25	biofouling	biofoule	VERB
gs-3799	670	26	,	,	PUNCT
gs-3799	670	27	and	and	CCONJ
gs-3799	670	28	seamless	seamless	ADJ
gs-3799	670	29	multi	multi	ADJ
gs-3799	670	30	-	-	ADJ
gs-3799	670	31	omics	omics	ADJ
gs-3799	670	32	integration	integration	NOUN
gs-3799	670	33	—	—	PUNCT
gs-3799	670	34	to	to	PART
gs-3799	670	35	provide	provide	VERB
gs-3799	670	36	the	the	DET
gs-3799	670	37	high	high	ADJ
gs-3799	670	38	-	-	PUNCT
gs-3799	670	39	fidelity	fidelity	NOUN
gs-3799	670	40	data	datum	NOUN
gs-3799	670	41	required	require	VERB
gs-3799	670	42	for	for	ADP
gs-3799	670	43	autonomous	autonomous	ADJ
gs-3799	670	44	decision	decision	NOUN
gs-3799	670	45	-	-	PUNCT
gs-3799	670	46	making	making	NOUN
gs-3799	670	47	.	.	PUNCT
gs-3799	671	1	future	future	ADJ
gs-3799	671	2	architectures	architecture	NOUN
gs-3799	671	3	should	should	AUX
gs-3799	671	4	unify	unify	VERB
gs-3799	671	5	all	all	DET
gs-3799	671	6	cpb	cpb	PROPN
gs-3799	671	7	subsystems	subsystem	NOUN
gs-3799	671	8	(	(	PUNCT
gs-3799	671	9	pump	pump	NOUN
gs-3799	671	10	,	,	PUNCT
gs-3799	671	11	oxygenation	oxygenation	NOUN
gs-3799	671	12	,	,	PUNCT
gs-3799	671	13	temperature	temperature	NOUN
gs-3799	671	14	,	,	PUNCT
gs-3799	671	15	and	and	CCONJ
gs-3799	671	16	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	671	17	)	)	PUNCT
gs-3799	671	18	under	under	ADP
gs-3799	671	19	a	a	DET
gs-3799	671	20	single	single	ADJ
gs-3799	671	21	ai	ai	NOUN
gs-3799	671	22	orchestrator	orchestrator	NOUN
gs-3799	671	23	capable	capable	ADJ
gs-3799	671	24	of	of	ADP
gs-3799	671	25	real	real	ADJ
gs-3799	671	26	-	-	PUNCT
gs-3799	671	27	time	time	NOUN
gs-3799	671	28	whole	whole	ADJ
gs-3799	671	29	-	-	PUNCT
gs-3799	671	30	body	body	NOUN
gs-3799	671	31	physiological	physiological	ADJ
gs-3799	671	32	modeling	modeling	NOUN
gs-3799	671	33	,	,	PUNCT
gs-3799	671	34	potentially	potentially	ADV
gs-3799	671	35	accelerated	accelerate	VERB
gs-3799	671	36	by	by	ADP
gs-3799	671	37	quantum	quantum	NOUN
gs-3799	671	38	computing	computing	NOUN
gs-3799	671	39	applications	application	NOUN
gs-3799	671	40	.	.	PUNCT
gs-3799	672	1	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	672	2	integration	integration	NOUN
gs-3799	672	3	must	must	AUX
gs-3799	672	4	expand	expand	VERB
gs-3799	672	5	beyond	beyond	ADP
gs-3799	672	6	anticoagulation	anticoagulation	NOUN
gs-3799	672	7	.	.	PUNCT
gs-3799	673	1	closed	close	VERB
gs-3799	673	2	-	-	PUNCT
gs-3799	673	3	loop	loop	NOUN
gs-3799	673	4	delivery	delivery	NOUN
gs-3799	673	5	of	of	ADP
gs-3799	673	6	vasoactive	vasoactive	ADJ
gs-3799	673	7	agents	agent	NOUN
gs-3799	673	8	guided	guide	VERB
gs-3799	673	9	by	by	ADP
gs-3799	673	10	machine	machine	NOUN
gs-3799	673	11	learning	learning	NOUN
gs-3799	673	12	-	-	PUNCT
gs-3799	673	13	derived	derive	VERB
gs-3799	673	14	hemodynamic	hemodynamic	ADJ
gs-3799	673	15	indices	index	NOUN
gs-3799	673	16	,	,	PUNCT
gs-3799	673	17	automated	automate	VERB
gs-3799	673	18	antiinflammatory	antiinflammatory	NOUN
gs-3799	673	19	dosing	dosing	NOUN
gs-3799	673	20	(	(	PUNCT
gs-3799	673	21	e.g.	e.g.	ADV
gs-3799	673	22	,	,	PUNCT
gs-3799	673	23	compstatin	compstatin	ADJ
gs-3799	673	24	analogs	analog	NOUN
gs-3799	673	25	)	)	PUNCT
gs-3799	673	26	calibrated	calibrate	VERB
gs-3799	673	27	to	to	PART
gs-3799	673	28	cytokine	cytokine	VERB
gs-3799	673	29	kinetics	kinetic	NOUN
gs-3799	673	30	,	,	PUNCT
gs-3799	673	31	and	and	CCONJ
gs-3799	673	32	nanocarrier	nanocarrier	NOUN
gs-3799	673	33	-	-	PUNCT
gs-3799	673	34	enabled	enable	VERB
gs-3799	673	35	organ	organ	NOUN
gs-3799	673	36	-	-	PUNCT
gs-3799	673	37	specific	specific	ADJ
gs-3799	673	38	drug	drug	NOUN
gs-3799	673	39	targeting	target	VERB
gs-3799	673	40	represent	represent	VERB
gs-3799	673	41	transformative	transformative	ADJ
gs-3799	673	42	opportunities	opportunity	NOUN
gs-3799	673	43	.	.	PUNCT
gs-3799	674	1	integrating	integrate	VERB
gs-3799	674	2	pharmacogenomic	pharmacogenomic	ADJ
gs-3799	674	3	data	datum	NOUN
gs-3799	674	4	—	—	PUNCT
gs-3799	674	5	such	such	ADJ
gs-3799	674	6	as	as	ADP
gs-3799	674	7	point	point	NOUN
gs-3799	674	8	-	-	PUNCT
gs-3799	674	9	of	of	ADP
gs-3799	674	10	-	-	PUNCT
gs-3799	674	11	care	care	NOUN
gs-3799	674	12	cyp2c9	cyp2c9	NOUN
gs-3799	674	13	genotyping	genotyping	NOUN
gs-3799	674	14	to	to	PART
gs-3799	674	15	personalize	personalize	VERB
gs-3799	674	16	heparin	heparin	ADJ
gs-3799	674	17	responsiveness	responsiveness	NOUN
gs-3799	674	18	—	—	PUNCT
gs-3799	674	19	will	will	AUX
gs-3799	674	20	further	far	ADV
gs-3799	674	21	refine	refine	VERB
gs-3799	674	22	precision	precision	NOUN
gs-3799	674	23	dosing	dose	VERB
gs-3799	674	24	.	.	PUNCT
gs-3799	675	1	concurrently	concurrently	ADV
gs-3799	675	2	,	,	PUNCT
gs-3799	675	3	human	human	ADJ
gs-3799	675	4	-	-	PUNCT
gs-3799	675	5	machine	machine	NOUN
gs-3799	675	6	interaction	interaction	NOUN
gs-3799	675	7	requires	require	VERB
gs-3799	675	8	reimagining	reimagine	VERB
gs-3799	675	9	:	:	PUNCT
gs-3799	675	10	adaptive	adaptive	ADJ
gs-3799	675	11	automation	automation	NOUN
gs-3799	675	12	systems	system	NOUN
gs-3799	675	13	should	should	AUX
gs-3799	675	14	dynamically	dynamically	ADV
gs-3799	675	15	modulate	modulate	VERB
gs-3799	675	16	autonomy	autonomy	NOUN
gs-3799	675	17	levels	level	NOUN
gs-3799	675	18	during	during	ADP
gs-3799	675	19	surgical	surgical	ADJ
gs-3799	675	20	phases	phase	NOUN
gs-3799	675	21	,	,	PUNCT
gs-3799	675	22	while	while	SCONJ
gs-3799	675	23	augmented	augment	VERB
gs-3799	675	24	reality	reality	NOUN
gs-3799	675	25	interfaces	interface	NOUN
gs-3799	675	26	could	could	AUX
gs-3799	675	27	overlay	overlay	VERB
gs-3799	675	28	predictive	predictive	ADJ
gs-3799	675	29	analytics	analytic	NOUN
gs-3799	675	30	and	and	CCONJ
gs-3799	675	31	protocol	protocol	NOUN
gs-3799	675	32	guidance	guidance	NOUN
gs-3799	675	33	to	to	ADP
gs-3799	675	34	transition	transition	NOUN
gs-3799	675	35	perfusionists	perfusionist	NOUN
gs-3799	675	36	into	into	ADP
gs-3799	675	37	system	system	NOUN
gs-3799	675	38	-	-	PUNCT
gs-3799	675	39	supervisor	supervisor	NOUN
gs-3799	675	40	roles	role	NOUN
gs-3799	675	41	.	.	PUNCT
gs-3799	676	1	standardized	standardize	VERB
gs-3799	676	2	training	training	NOUN
gs-3799	676	3	frameworks	framework	NOUN
gs-3799	676	4	for	for	ADP
gs-3799	676	5	closed	closed	ADJ
gs-3799	676	6	-	-	PUNCT
gs-3799	676	7	loop	loop	NOUN
gs-3799	676	8	crisis	crisis	NOUN
gs-3799	676	9	management	management	NOUN
gs-3799	676	10	and	and	CCONJ
gs-3799	676	11	ai	ai	PRON
gs-3799	676	12	oversight	oversight	NOUN
gs-3799	676	13	will	will	AUX
gs-3799	676	14	be	be	AUX
gs-3799	676	15	essential	essential	ADJ
gs-3799	676	16	to	to	PART
gs-3799	676	17	support	support	VERB
gs-3799	676	18	this	this	DET
gs-3799	676	19	paradigm	paradigm	NOUN
gs-3799	676	20	shift	shift	NOUN
gs-3799	676	21	.	.	PUNCT
gs-3799	677	1	implementation	implementation	NOUN
gs-3799	677	2	success	success	NOUN
gs-3799	677	3	hinges	hinge	VERB
gs-3799	677	4	on	on	ADP
gs-3799	677	5	constructing	construct	VERB
gs-3799	677	6	supportive	supportive	ADJ
gs-3799	677	7	ecosystems	ecosystem	NOUN
gs-3799	677	8	.	.	PUNCT
gs-3799	678	1	regulatory	regulatory	ADJ
gs-3799	678	2	harmonization	harmonization	NOUN
gs-3799	678	3	via	via	ADP
gs-3799	678	4	iso	iso	PROPN
gs-3799	678	5	/	/	SYM
gs-3799	678	6	astm	astm	PROPN
gs-3799	678	7	standards	standard	NOUN
gs-3799	678	8	specific	specific	ADJ
gs-3799	678	9	to	to	ADP
gs-3799	678	10	closed	close	VERB
gs-3799	678	11	-	-	PUNCT
gs-3799	678	12	loop	loop	NOUN
gs-3799	678	13	safety	safety	NOUN
gs-3799	678	14	,	,	PUNCT
gs-3799	678	15	cybersecurity	cybersecurity	NOUN
gs-3799	678	16	,	,	PUNCT
gs-3799	678	17	and	and	CCONJ
gs-3799	678	18	validation	validation	NOUN
gs-3799	678	19	protocols	protocol	NOUN
gs-3799	678	20	is	be	AUX
gs-3799	678	21	urgently	urgently	ADV
gs-3799	678	22	needed	need	VERB
gs-3799	678	23	.	.	PUNCT
gs-3799	679	1	interoperability	interoperability	NOUN
gs-3799	679	2	mandates	mandate	NOUN
gs-3799	679	3	ensuring	ensure	VERB
gs-3799	679	4	vendor	vendor	NOUN
gs-3799	679	5	-	-	PUNCT
gs-3799	679	6	agnostic	agnostic	ADJ
gs-3799	679	7	data	datum	NOUN
gs-3799	679	8	exchange	exchange	NOUN
gs-3799	679	9	between	between	ADP
gs-3799	679	10	cpb	cpb	PROPN
gs-3799	679	11	devices	device	NOUN
gs-3799	679	12	,	,	PUNCT
gs-3799	679	13	electronic	electronic	ADJ
gs-3799	679	14	health	health	NOUN
gs-3799	679	15	records	record	NOUN
gs-3799	679	16	,	,	PUNCT
gs-3799	679	17	and	and	CCONJ
gs-3799	679	18	intensive	intensive	ADJ
gs-3799	679	19	care	care	NOUN
gs-3799	679	20	platforms	platform	NOUN
gs-3799	679	21	—	—	PUNCT
gs-3799	679	22	using	use	VERB
gs-3799	679	23	frameworks	framework	NOUN
gs-3799	679	24	like	like	ADP
gs-3799	679	25	hl7	hl7	NOUN
gs-3799	679	26	fhir	fhir	NOUN
gs-3799	679	27	—	—	PUNCT
gs-3799	679	28	will	will	AUX
gs-3799	679	29	enable	enable	VERB
gs-3799	679	30	continuous	continuous	ADJ
gs-3799	679	31	care	care	NOUN
gs-3799	679	32	integration	integration	NOUN
gs-3799	679	33	.	.	PUNCT
gs-3799	680	1	globally	globally	ADV
gs-3799	680	2	,	,	PUNCT
gs-3799	680	3	modular	modular	ADJ
gs-3799	680	4	and	and	CCONJ
gs-3799	680	5	cost	cost	NOUN
gs-3799	680	6	-	-	PUNCT
gs-3799	680	7	optimized	optimize	VERB
gs-3799	680	8	designs	design	NOUN
gs-3799	680	9	must	must	AUX
gs-3799	680	10	be	be	AUX
gs-3799	680	11	prioritized	prioritize	VERB
gs-3799	680	12	to	to	PART
gs-3799	680	13	ensure	ensure	VERB
gs-3799	680	14	equitable	equitable	ADJ
gs-3799	680	15	access	access	NOUN
gs-3799	680	16	,	,	PUNCT
gs-3799	680	17	particularly	particularly	ADV
gs-3799	680	18	in	in	ADP
gs-3799	680	19	resource	resource	NOUN
gs-3799	680	20	-	-	PUNCT
gs-3799	680	21	limited	limit	VERB
gs-3799	680	22	settings	setting	NOUN
gs-3799	680	23	where	where	SCONJ
gs-3799	680	24	batteryoperated	batteryoperate	VERB
gs-3799	680	25	closed	closed	ADJ
gs-3799	680	26	-	-	PUNCT
gs-3799	680	27	loop	loop	NOUN
gs-3799	680	28	modules	module	NOUN
gs-3799	680	29	could	could	AUX
gs-3799	680	30	transform	transform	VERB
gs-3799	680	31	off	off	ADP
gs-3799	680	32	-	-	PUNCT
gs-3799	680	33	pump	pump	VERB
gs-3799	680	34	surgical	surgical	ADJ
gs-3799	680	35	safety	safety	NOUN
gs-3799	680	36	.	.	PUNCT
gs-3799	681	1	near	near	ADJ
gs-3799	681	2	-	-	PUNCT
gs-3799	681	3	term	term	NOUN
gs-3799	681	4	priorities	priority	NOUN
gs-3799	681	5	should	should	AUX
gs-3799	681	6	establish	establish	VERB
gs-3799	681	7	multicenter	multicenter	ADJ
gs-3799	681	8	trial	trial	NOUN
gs-3799	681	9	consortia	consortia	NOUN
gs-3799	681	10	,	,	PUNCT
gs-3799	681	11	open	open	ADJ
gs-3799	681	12	-	-	PUNCT
gs-3799	681	13	source	source	NOUN
gs-3799	681	14	algorithm	algorithm	NOUN
gs-3799	681	15	validation	validation	NOUN
gs-3799	681	16	platforms	platform	NOUN
gs-3799	681	17	,	,	PUNCT
gs-3799	681	18	and	and	CCONJ
gs-3799	681	19	standardized	standardize	VERB
gs-3799	681	20	apis	apis	NOUN
gs-3799	681	21	for	for	ADP
gs-3799	681	22	sensor	sensor	NOUN
gs-3799	681	23	-	-	PUNCT
gs-3799	681	24	data	datum	NOUN
gs-3799	681	25	fusion	fusion	NOUN
gs-3799	681	26	.	.	PUNCT
gs-3799	682	1	mid	mid	ADJ
gs-3799	682	2	-	-	ADJ
gs-3799	682	3	term	term	NOUN
gs-3799	682	4	goals	goal	NOUN
gs-3799	682	5	(	(	PUNCT
gs-3799	682	6	3–5	3–5	NUM
gs-3799	682	7	years	year	NOUN
gs-3799	682	8	)	)	PUNCT
gs-3799	682	9	must	must	AUX
gs-3799	682	10	demonstrate	demonstrate	VERB
gs-3799	682	11	ai	ai	VERB
gs-3799	682	12	-	-	PUNCT
gs-3799	682	13	driven	drive	VERB
gs-3799	682	14	perfusion	perfusion	NOUN
gs-3799	682	15	"	"	PUNCT
gs-3799	682	16	digital	digital	ADJ
gs-3799	682	17	twins	twin	NOUN
gs-3799	682	18	"	"	PUNCT
gs-3799	682	19	in	in	ADP
gs-3799	682	20	simulated	simulated	ADJ
gs-3799	682	21	environments	environment	NOUN
gs-3799	682	22	,	,	PUNCT
gs-3799	682	23	while	while	SCONJ
gs-3799	682	24	long	long	ADJ
gs-3799	682	25	-	-	PUNCT
gs-3799	682	26	term	term	NOUN
gs-3799	682	27	visions	vision	NOUN
gs-3799	682	28	(	(	PUNCT
gs-3799	682	29	5–10	5–10	ADJ
gs-3799	682	30	years	year	NOUN
gs-3799	682	31	)	)	PUNCT
gs-3799	682	32	target	target	VERB
gs-3799	682	33	fully	fully	ADV
gs-3799	682	34	autonomous	autonomous	ADJ
gs-3799	682	35	cpb	cpb	NOUN
gs-3799	682	36	for	for	ADP
gs-3799	682	37	routine	routine	ADJ
gs-3799	682	38	coronary	coronary	ADJ
gs-3799	682	39	bypass	bypass	NOUN
gs-3799	682	40	,	,	PUNCT
gs-3799	682	41	supported	support	VERB
gs-3799	682	42	by	by	ADP
gs-3799	682	43	global	global	ADJ
gs-3799	682	44	outcome	outcome	NOUN
gs-3799	682	45	registries	registry	NOUN
gs-3799	682	46	and	and	CCONJ
gs-3799	682	47	who	who	PRON
gs-3799	682	48	-	-	PUNCT
gs-3799	682	49	endorsed	endorse	VERB
gs-3799	682	50	deployment	deployment	NOUN
gs-3799	682	51	in	in	ADP
gs-3799	682	52	low	low	ADJ
gs-3799	682	53	-	-	PUNCT
gs-3799	682	54	resource	resource	NOUN
gs-3799	682	55	regions	region	NOUN
gs-3799	682	56	.	.	PUNCT
gs-3799	683	1	achieving	achieve	VERB
gs-3799	683	2	this	this	DET
gs-3799	683	3	trajectory	trajectory	NOUN
gs-3799	683	4	demands	demand	VERB
gs-3799	683	5	unprecedented	unprecedented	ADJ
gs-3799	683	6	collaboration	collaboration	NOUN
gs-3799	683	7	across	across	ADP
gs-3799	683	8	clinicians	clinician	NOUN
gs-3799	683	9	,	,	PUNCT
gs-3799	683	10	engineers	engineer	NOUN
gs-3799	683	11	,	,	PUNCT
gs-3799	683	12	regulators	regulator	NOUN
gs-3799	683	13	,	,	PUNCT
gs-3799	683	14	and	and	CCONJ
gs-3799	683	15	industry	industry	NOUN
gs-3799	683	16	—	—	PUNCT
gs-3799	683	17	grounded	ground	VERB
gs-3799	683	18	in	in	ADP
gs-3799	683	19	ethical	ethical	ADJ
gs-3799	683	20	ai	ai	NOUN
gs-3799	683	21	development	development	NOUN
gs-3799	683	22	and	and	CCONJ
gs-3799	683	23	relentless	relentless	ADJ
gs-3799	683	24	focus	focus	NOUN
gs-3799	683	25	on	on	ADP
gs-3799	683	26	patient	patient	NOUN
gs-3799	683	27	-	-	PUNCT
gs-3799	683	28	centered	center	VERB
gs-3799	683	29	outcomes	outcome	NOUN
gs-3799	683	30	—	—	PUNCT
gs-3799	683	31	to	to	PART
gs-3799	683	32	transition	transition	VERB
gs-3799	683	33	intelligent	intelligent	ADJ
gs-3799	683	34	perfusion	perfusion	NOUN
gs-3799	683	35	from	from	ADP
gs-3799	683	36	technical	technical	ADJ
gs-3799	683	37	ambition	ambition	NOUN
gs-3799	683	38	to	to	ADP
gs-3799	683	39	standardized	standardized	ADJ
gs-3799	683	40	therapeutic	therapeutic	ADJ
gs-3799	683	41	reality	reality	NOUN
gs-3799	683	42	.	.	PUNCT
gs-3799	684	1	suggestions	suggestion	NOUN
gs-3799	684	2	based	base	VERB
gs-3799	684	3	on	on	ADP
gs-3799	684	4	the	the	DET
gs-3799	684	5	detection	detection	NOUN
gs-3799	684	6	and	and	CCONJ
gs-3799	684	7	current	current	ADJ
gs-3799	684	8	restraints	restraint	NOUN
gs-3799	684	9	in	in	ADP
gs-3799	684	10	this	this	DET
gs-3799	684	11	area	area	NOUN
gs-3799	684	12	of	of	ADP
gs-3799	684	13	field	field	NOUN
gs-3799	684	14	,	,	PUNCT
gs-3799	684	15	various	various	ADJ
gs-3799	684	16	practical	practical	ADJ
gs-3799	684	17	and	and	CCONJ
gs-3799	684	18	researchbased	researchbase	VERB
gs-3799	684	19	tips	tip	NOUN
gs-3799	684	20	are	be	AUX
gs-3799	684	21	offered	offer	VERB
gs-3799	684	22	:	:	PUNCT
gs-3799	684	23	growth	growth	NOUN
gs-3799	684	24	of	of	ADP
gs-3799	684	25	pediatric	pediatric	ADJ
gs-3799	684	26	-	-	PUNCT
gs-3799	684	27	specific	specific	ADJ
gs-3799	684	28	procedures	procedure	NOUN
gs-3799	684	29	:	:	PUNCT
gs-3799	684	30	current	current	ADJ
gs-3799	684	31	control	control	NOUN
gs-3799	684	32	procedures	procedure	NOUN
gs-3799	684	33	are	be	AUX
gs-3799	684	34	often	often	ADV
gs-3799	684	35	altered	alter	VERB
gs-3799	684	36	from	from	ADP
gs-3799	684	37	adult	adult	NOUN
gs-3799	684	38	models	model	NOUN
gs-3799	684	39	.	.	PUNCT
gs-3799	685	1	there	there	PRON
gs-3799	685	2	is	be	VERB
gs-3799	685	3	a	a	DET
gs-3799	685	4	strong	strong	ADJ
gs-3799	685	5	urge	urge	NOUN
gs-3799	685	6	for	for	ADP
gs-3799	685	7	development	development	NOUN
gs-3799	685	8	and	and	CCONJ
gs-3799	685	9	confirmation	confirmation	NOUN
gs-3799	685	10	of	of	ADP
gs-3799	685	11	pediatricand	pediatricand	NOUN
gs-3799	685	12	neonate	neonate	NOUN
gs-3799	685	13	-	-	PUNCT
gs-3799	685	14	specific	specific	ADJ
gs-3799	685	15	control	control	NOUN
gs-3799	685	16	agreements	agreement	NOUN
gs-3799	685	17	that	that	PRON
gs-3799	685	18	are	be	AUX
gs-3799	685	19	reported	report	VERB
gs-3799	685	20	for	for	ADP
gs-3799	685	21	special	special	ADJ
gs-3799	685	22	hemodynamic	hemodynamic	ADJ
gs-3799	685	23	and	and	CCONJ
gs-3799	685	24	metabolic	metabolic	NOUN
gs-3799	685	25	requirements	requirement	NOUN
gs-3799	685	26	.	.	PUNCT
gs-3799	686	1	georgian	georgian	NOUN
gs-3799	686	2	scientists/	scientists/	NUM
gs-3799	686	3	.	.	PUNCT
gs-3799	687	1	7	7	NUM
gs-3799	687	2	n	n	PRON
gs-3799	687	3	2	2	NUM
gs-3799	687	4	,	,	PUNCT
gs-3799	687	5	2025	2025	NUM
gs-3799	687	6	414	414	NUM
gs-3799	687	7	encourage	encourage	VERB
gs-3799	687	8	interdisciplinary	interdisciplinary	ADJ
gs-3799	687	9	research	research	NOUN
gs-3799	687	10	:	:	PUNCT
gs-3799	687	11	close	close	ADJ
gs-3799	687	12	partnership	partnership	NOUN
gs-3799	687	13	between	between	ADP
gs-3799	687	14	pediatric	pediatric	ADJ
gs-3799	687	15	cardiac	cardiac	ADJ
gs-3799	687	16	teams	team	NOUN
gs-3799	687	17	and	and	CCONJ
gs-3799	687	18	biomedical	biomedical	ADJ
gs-3799	687	19	engineers	engineer	NOUN
gs-3799	687	20	is	be	AUX
gs-3799	687	21	something	something	PRON
gs-3799	687	22	very	very	ADV
gs-3799	687	23	important	important	ADJ
gs-3799	687	24	for	for	ADP
gs-3799	687	25	efficacious	efficacious	ADJ
gs-3799	687	26	system	system	NOUN
gs-3799	687	27	design	design	NOUN
gs-3799	687	28	and	and	CCONJ
gs-3799	687	29	examination	examination	NOUN
gs-3799	687	30	.	.	PUNCT
gs-3799	688	1	simulation	simulation	NOUN
gs-3799	688	2	-	-	PUNCT
gs-3799	688	3	based	base	VERB
gs-3799	688	4	education	education	NOUN
gs-3799	688	5	can	can	AUX
gs-3799	688	6	be	be	AUX
gs-3799	688	7	enlarged	enlarge	VERB
gs-3799	688	8	to	to	PART
gs-3799	688	9	test	test	VERB
gs-3799	688	10	various	various	ADJ
gs-3799	688	11	clinical	clinical	ADJ
gs-3799	688	12	frameworks	framework	NOUN
gs-3799	688	13	and	and	CCONJ
gs-3799	688	14	feedbacks	feedback	NOUN
gs-3799	688	15	.	.	PUNCT
gs-3799	689	1	systemize	systemize	VERB
gs-3799	689	2	sensor	sensor	NOUN
gs-3799	689	3	accuracy	accuracy	NOUN
gs-3799	689	4	metrics	metric	NOUN
gs-3799	689	5	:	:	PUNCT
gs-3799	689	6	changes	change	NOUN
gs-3799	689	7	in	in	ADP
gs-3799	689	8	real	real	ADJ
gs-3799	689	9	-	-	PUNCT
gs-3799	689	10	time	time	NOUN
gs-3799	689	11	sensor	sensor	NOUN
gs-3799	689	12	authenticity	authenticity	NOUN
gs-3799	689	13	—	—	PUNCT
gs-3799	689	14	especially	especially	ADV
gs-3799	689	15	in	in	ADP
gs-3799	689	16	neonates	neonate	NOUN
gs-3799	689	17	—	—	PUNCT
gs-3799	689	18	should	should	AUX
gs-3799	689	19	be	be	AUX
gs-3799	689	20	labeled	label	VERB
gs-3799	689	21	through	through	ADP
gs-3799	689	22	standardized	standardized	ADJ
gs-3799	689	23	exam	exam	NOUN
gs-3799	689	24	protocols	protocol	NOUN
gs-3799	689	25	and	and	CCONJ
gs-3799	689	26	repeated	repeat	VERB
gs-3799	689	27	systems	system	NOUN
gs-3799	689	28	.	.	PUNCT
gs-3799	690	1	execute	execute	VERB
gs-3799	690	2	hybrid	hybrid	ADJ
gs-3799	690	3	models	model	NOUN
gs-3799	690	4	:	:	PUNCT
gs-3799	690	5	semi	semi	ADJ
gs-3799	690	6	-	-	ADJ
gs-3799	690	7	automated	automated	ADJ
gs-3799	690	8	systems	system	NOUN
gs-3799	690	9	that	that	PRON
gs-3799	690	10	merge	merge	VERB
gs-3799	690	11	closed	close	VERB
gs-3799	690	12	-	-	PUNCT
gs-3799	690	13	loop	loop	NOUN
gs-3799	690	14	mechanization	mechanization	NOUN
gs-3799	690	15	with	with	ADP
gs-3799	690	16	realduration	realduration	NOUN
gs-3799	690	17	clinician	clinician	NOUN
gs-3799	690	18	inspection	inspection	NOUN
gs-3799	690	19	may	may	AUX
gs-3799	690	20	be	be	AUX
gs-3799	690	21	of	of	ADP
gs-3799	690	22	use	use	NOUN
gs-3799	690	23	as	as	ADP
gs-3799	690	24	a	a	DET
gs-3799	690	25	safe	safe	ADJ
gs-3799	690	26	intermediate	intermediate	ADJ
gs-3799	690	27	model	model	NOUN
gs-3799	690	28	before	before	SCONJ
gs-3799	690	29	entirely	entirely	ADV
gs-3799	690	30	autonomous	autonomous	ADJ
gs-3799	690	31	systems	system	NOUN
gs-3799	690	32	are	be	AUX
gs-3799	690	33	universally	universally	ADV
gs-3799	690	34	agreed	agree	VERB
gs-3799	690	35	upon	upon	SCONJ
gs-3799	690	36	.	.	PUNCT
gs-3799	691	1	promote	promote	VERB
gs-3799	691	2	regulatory	regulatory	ADJ
gs-3799	691	3	help	help	NOUN
gs-3799	691	4	:	:	PUNCT
gs-3799	691	5	stated	state	VERB
gs-3799	691	6	the	the	DET
gs-3799	691	7	originality	originality	NOUN
gs-3799	691	8	and	and	CCONJ
gs-3799	691	9	capable	capable	ADJ
gs-3799	691	10	impact	impact	NOUN
gs-3799	691	11	of	of	ADP
gs-3799	691	12	these	these	DET
gs-3799	691	13	systems	system	NOUN
gs-3799	691	14	,	,	PUNCT
gs-3799	691	15	early	early	ADJ
gs-3799	691	16	participation	participation	NOUN
gs-3799	691	17	with	with	ADP
gs-3799	691	18	regulatory	regulatory	ADJ
gs-3799	691	19	authorities	authority	NOUN
gs-3799	691	20	will	will	AUX
gs-3799	691	21	help	help	VERB
gs-3799	691	22	support	support	VERB
gs-3799	691	23	and	and	CCONJ
gs-3799	691	24	define	define	VERB
gs-3799	691	25	safety	safety	NOUN
gs-3799	691	26	excellence	excellence	NOUN
gs-3799	691	27	,	,	PUNCT
gs-3799	691	28	assist	assist	VERB
gs-3799	691	29	in	in	ADP
gs-3799	691	30	ethical	ethical	ADJ
gs-3799	691	31	use	use	NOUN
gs-3799	691	32	,	,	PUNCT
gs-3799	691	33	and	and	CCONJ
gs-3799	691	34	accommodated	accommodate	VERB
gs-3799	691	35	clinical	clinical	ADJ
gs-3799	691	36	testing	testing	NOUN
gs-3799	691	37	.	.	PUNCT
gs-3799	692	1	widely	widely	ADV
gs-3799	692	2	improve	improve	VERB
gs-3799	692	3	training	training	NOUN
gs-3799	692	4	and	and	CCONJ
gs-3799	692	5	education	education	NOUN
gs-3799	692	6	:	:	PUNCT
gs-3799	692	7	including	include	VERB
gs-3799	692	8	simulation	simulation	NOUN
gs-3799	692	9	modules	module	NOUN
gs-3799	692	10	and	and	CCONJ
gs-3799	692	11	participating	participate	VERB
gs-3799	692	12	actively	actively	ADV
gs-3799	692	13	in	in	ADP
gs-3799	692	14	training	training	NOUN
gs-3799	692	15	for	for	ADP
gs-3799	692	16	perfusionists	perfusionist	NOUN
gs-3799	692	17	and	and	CCONJ
gs-3799	692	18	surgical	surgical	ADJ
gs-3799	692	19	teams	team	NOUN
gs-3799	692	20	will	will	AUX
gs-3799	692	21	set	set	VERB
gs-3799	692	22	the	the	DET
gs-3799	692	23	seal	seal	NOUN
gs-3799	692	24	and	and	CCONJ
gs-3799	692	25	guarantee	guarantee	VERB
gs-3799	692	26	confident	confident	ADJ
gs-3799	692	27	and	and	CCONJ
gs-3799	692	28	safe	safe	ADJ
gs-3799	692	29	use	use	NOUN
gs-3799	692	30	of	of	ADP
gs-3799	692	31	closed	closed	ADJ
gs-3799	692	32	-	-	PUNCT
gs-3799	692	33	loop	loop	NOUN
gs-3799	692	34	innovations	innovation	NOUN
gs-3799	692	35	.	.	PUNCT
gs-3799	693	1	put	put	VERB
gs-3799	693	2	money	money	NOUN
gs-3799	693	3	into	into	ADP
gs-3799	693	4	cost	cost	NOUN
gs-3799	693	5	-	-	PUNCT
gs-3799	693	6	effective	effective	ADJ
gs-3799	693	7	devices	device	NOUN
gs-3799	693	8	:	:	PUNCT
gs-3799	693	9	to	to	PART
gs-3799	693	10	make	make	VERB
gs-3799	693	11	certain	certain	ADJ
gs-3799	693	12	wide	wide	ADJ
gs-3799	693	13	access	access	NOUN
gs-3799	693	14	,	,	PUNCT
gs-3799	693	15	future	future	ADJ
gs-3799	693	16	systems	system	NOUN
gs-3799	693	17	must	must	AUX
gs-3799	693	18	rank	rank	VERB
gs-3799	693	19	affordability	affordability	NOUN
gs-3799	693	20	and	and	CCONJ
gs-3799	693	21	relief	relief	NOUN
gs-3799	693	22	of	of	ADP
gs-3799	693	23	incorporation	incorporation	NOUN
gs-3799	693	24	into	into	ADP
gs-3799	693	25	already	already	ADV
gs-3799	693	26	there	there	ADV
gs-3799	693	27	surgical	surgical	ADJ
gs-3799	693	28	infrastructure	infrastructure	NOUN
gs-3799	693	29	,	,	PUNCT
gs-3799	693	30	principally	principally	ADV
gs-3799	693	31	in	in	ADP
gs-3799	693	32	resource	resource	NOUN
gs-3799	693	33	-	-	PUNCT
gs-3799	693	34	restricted	restrict	VERB
gs-3799	693	35	settings	setting	NOUN
gs-3799	693	36	.	.	PUNCT
gs-3799	694	1	conclusion	conclusion	NOUN
gs-3799	694	2	closed	close	VERB
gs-3799	694	3	-	-	PUNCT
gs-3799	694	4	loop	loop	NOUN
gs-3799	694	5	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	694	6	bypass	bypass	NOUN
gs-3799	694	7	systems	system	NOUN
gs-3799	694	8	have	have	AUX
gs-3799	694	9	proven	prove	VERB
gs-3799	694	10	to	to	PART
gs-3799	694	11	be	be	AUX
gs-3799	694	12	a	a	DET
gs-3799	694	13	remarkable	remarkable	ADJ
gs-3799	694	14	advancement	advancement	NOUN
gs-3799	694	15	in	in	ADP
gs-3799	694	16	pediatric	pediatric	ADJ
gs-3799	694	17	cardiac	cardiac	ADJ
gs-3799	694	18	surgery	surgery	NOUN
gs-3799	694	19	,	,	PUNCT
gs-3799	694	20	demonstrating	demonstrate	VERB
gs-3799	694	21	a	a	DET
gs-3799	694	22	notable	notable	ADJ
gs-3799	694	23	improvement	improvement	NOUN
gs-3799	694	24	in	in	ADP
gs-3799	694	25	hemodynamic	hemodynamic	ADJ
gs-3799	694	26	stability	stability	NOUN
gs-3799	694	27	,	,	PUNCT
gs-3799	694	28	limiting	limit	VERB
gs-3799	694	29	the	the	DET
gs-3799	694	30	fluctuations	fluctuation	NOUN
gs-3799	694	31	of	of	ADP
gs-3799	694	32	intraoperative	intraoperative	ADJ
gs-3799	694	33	parameters	parameter	NOUN
gs-3799	694	34	and	and	CCONJ
gs-3799	694	35	resulting	result	VERB
gs-3799	694	36	in	in	ADP
gs-3799	694	37	an	an	DET
gs-3799	694	38	all	all	PRON
gs-3799	694	39	-	-	PUNCT
gs-3799	694	40	round	round	NOUN
gs-3799	694	41	improvement	improvement	NOUN
gs-3799	694	42	with	with	ADP
gs-3799	694	43	the	the	DET
gs-3799	694	44	child	child	NOUN
gs-3799	694	45	’s	’s	PART
gs-3799	694	46	outcome	outcome	NOUN
gs-3799	694	47	.	.	PUNCT
gs-3799	695	1	in	in	ADP
gs-3799	695	2	order	order	NOUN
gs-3799	695	3	to	to	PART
gs-3799	695	4	eliminate	eliminate	VERB
gs-3799	695	5	inaccuracies	inaccuracy	NOUN
gs-3799	695	6	that	that	PRON
gs-3799	695	7	could	could	AUX
gs-3799	695	8	ensue	ensue	VERB
gs-3799	695	9	with	with	ADP
gs-3799	695	10	manual	manual	ADJ
gs-3799	695	11	regulation	regulation	NOUN
gs-3799	695	12	of	of	ADP
gs-3799	695	13	numerous	numerous	ADJ
gs-3799	695	14	variables	variable	NOUN
gs-3799	695	15	,	,	PUNCT
gs-3799	695	16	these	these	DET
gs-3799	695	17	systems	system	NOUN
gs-3799	695	18	provide	provide	VERB
gs-3799	695	19	precision	precision	NOUN
gs-3799	695	20	&	&	CCONJ
gs-3799	695	21	stability	stability	NOUN
gs-3799	695	22	,	,	PUNCT
gs-3799	695	23	utilizing	utilize	VERB
gs-3799	695	24	devices	device	NOUN
gs-3799	695	25	that	that	PRON
gs-3799	695	26	instantaneously	instantaneously	ADV
gs-3799	695	27	record	record	VERB
gs-3799	695	28	and	and	CCONJ
gs-3799	695	29	generate	generate	VERB
gs-3799	695	30	algorithms	algorithm	NOUN
gs-3799	695	31	in	in	ADP
gs-3799	695	32	accordance	accordance	NOUN
gs-3799	695	33	with	with	ADP
gs-3799	695	34	the	the	DET
gs-3799	695	35	various	various	ADJ
gs-3799	695	36	physiological	physiological	ADJ
gs-3799	695	37	changes	change	NOUN
gs-3799	695	38	that	that	PRON
gs-3799	695	39	take	take	VERB
gs-3799	695	40	place	place	NOUN
gs-3799	695	41	.	.	PUNCT
gs-3799	696	1	this	this	DET
gs-3799	696	2	method	method	NOUN
gs-3799	696	3	has	have	AUX
gs-3799	696	4	marked	mark	VERB
gs-3799	696	5	benefits	benefit	NOUN
gs-3799	696	6	,	,	PUNCT
gs-3799	696	7	particularly	particularly	ADV
gs-3799	696	8	in	in	ADP
gs-3799	696	9	neonatal	neonatal	ADJ
gs-3799	696	10	and	and	CCONJ
gs-3799	696	11	infant	infant	NOUN
gs-3799	696	12	patients	patient	NOUN
gs-3799	696	13	,	,	PUNCT
gs-3799	696	14	who	who	PRON
gs-3799	696	15	are	be	AUX
gs-3799	696	16	prone	prone	ADJ
gs-3799	696	17	to	to	ADP
gs-3799	696	18	experiencing	experience	VERB
gs-3799	696	19	acute	acute	ADJ
gs-3799	696	20	and	and	CCONJ
gs-3799	696	21	rapid	rapid	ADJ
gs-3799	696	22	variations	variation	NOUN
gs-3799	696	23	in	in	ADP
gs-3799	696	24	their	their	PRON
gs-3799	696	25	physiological	physiological	ADJ
gs-3799	696	26	parameters	parameter	NOUN
gs-3799	696	27	.	.	PUNCT
gs-3799	697	1	such	such	ADJ
gs-3799	697	2	benefits	benefit	NOUN
gs-3799	697	3	are	be	AUX
gs-3799	697	4	inclusive	inclusive	ADJ
gs-3799	697	5	of	of	ADP
gs-3799	697	6	steady	steady	ADJ
gs-3799	697	7	perfusion	perfusion	NOUN
gs-3799	697	8	pressures	pressure	NOUN
gs-3799	697	9	,	,	PUNCT
gs-3799	697	10	better	well	ADJ
gs-3799	697	11	oxygen	oxygen	NOUN
gs-3799	697	12	delivery	delivery	NOUN
gs-3799	697	13	and	and	CCONJ
gs-3799	697	14	the	the	DET
gs-3799	697	15	potential	potential	NOUN
gs-3799	697	16	to	to	PART
gs-3799	697	17	eradicate	eradicate	VERB
gs-3799	697	18	dangers	danger	NOUN
gs-3799	697	19	pertaining	pertain	VERB
gs-3799	697	20	to	to	ADP
gs-3799	697	21	ischemia	ischemia	NOUN
gs-3799	697	22	.	.	PUNCT
gs-3799	698	1	recent	recent	ADJ
gs-3799	698	2	models	model	NOUN
gs-3799	698	3	have	have	AUX
gs-3799	698	4	showcased	showcase	VERB
gs-3799	698	5	advantages	advantage	NOUN
gs-3799	698	6	in	in	ADP
gs-3799	698	7	regard	regard	NOUN
gs-3799	698	8	to	to	ADP
gs-3799	698	9	safety	safety	NOUN
gs-3799	698	10	and	and	CCONJ
gs-3799	698	11	reaction	reaction	NOUN
gs-3799	698	12	time	time	NOUN
gs-3799	698	13	,	,	PUNCT
gs-3799	698	14	especially	especially	ADV
gs-3799	698	15	with	with	ADP
gs-3799	698	16	critical	critical	ADJ
gs-3799	698	17	factors	factor	NOUN
gs-3799	698	18	like	like	ADP
gs-3799	698	19	arterial	arterial	NOUN
gs-3799	698	20	pressure	pressure	NOUN
gs-3799	698	21	and	and	CCONJ
gs-3799	698	22	cerebral	cerebral	ADJ
gs-3799	698	23	oxygenation	oxygenation	NOUN
gs-3799	698	24	.	.	PUNCT
gs-3799	699	1	we	we	PRON
gs-3799	699	2	should	should	AUX
gs-3799	699	3	not	not	PART
gs-3799	699	4	be	be	AUX
gs-3799	699	5	oblivious	oblivious	ADJ
gs-3799	699	6	to	to	ADP
gs-3799	699	7	the	the	DET
gs-3799	699	8	many	many	ADJ
gs-3799	699	9	elements	element	NOUN
gs-3799	699	10	of	of	ADP
gs-3799	699	11	concern	concern	NOUN
gs-3799	699	12	which	which	PRON
gs-3799	699	13	should	should	AUX
gs-3799	699	14	be	be	AUX
gs-3799	699	15	addressed	address	VERB
gs-3799	699	16	.	.	PUNCT
gs-3799	700	1	some	some	PRON
gs-3799	700	2	of	of	ADP
gs-3799	700	3	the	the	DET
gs-3799	700	4	barriers	barrier	NOUN
gs-3799	700	5	preventing	prevent	VERB
gs-3799	700	6	the	the	DET
gs-3799	700	7	incorporation	incorporation	NOUN
gs-3799	700	8	of	of	ADP
gs-3799	700	9	this	this	DET
gs-3799	700	10	method	method	NOUN
gs-3799	700	11	are	be	AUX
gs-3799	700	12	the	the	DET
gs-3799	700	13	intricacy	intricacy	NOUN
gs-3799	700	14	of	of	ADP
gs-3799	700	15	children	child	NOUN
gs-3799	700	16	’s	’s	PART
gs-3799	700	17	physiology	physiology	NOUN
gs-3799	700	18	and	and	CCONJ
gs-3799	700	19	the	the	DET
gs-3799	700	20	much	much	ADV
gs-3799	700	21	-	-	PUNCT
gs-3799	700	22	needed	need	VERB
gs-3799	700	23	confidence	confidence	NOUN
gs-3799	700	24	of	of	ADP
gs-3799	700	25	the	the	DET
gs-3799	700	26	clinician	clinician	NOUN
gs-3799	700	27	,	,	PUNCT
gs-3799	700	28	along	along	ADP
gs-3799	700	29	with	with	ADP
gs-3799	700	30	expenses	expense	NOUN
gs-3799	700	31	to	to	PART
gs-3799	700	32	cover	cover	VERB
gs-3799	700	33	the	the	DET
gs-3799	700	34	cost	cost	NOUN
gs-3799	700	35	of	of	ADP
gs-3799	700	36	development	development	NOUN
gs-3799	700	37	and	and	CCONJ
gs-3799	700	38	utilization	utilization	NOUN
gs-3799	700	39	.	.	PUNCT
gs-3799	701	1	however	however	ADV
gs-3799	701	2	,	,	PUNCT
gs-3799	701	3	because	because	SCONJ
gs-3799	701	4	of	of	ADP
gs-3799	701	5	the	the	DET
gs-3799	701	6	rapid	rapid	ADJ
gs-3799	701	7	advancements	advancement	NOUN
gs-3799	701	8	in	in	ADP
gs-3799	701	9	technology	technology	NOUN
gs-3799	701	10	and	and	CCONJ
gs-3799	701	11	medicine	medicine	NOUN
gs-3799	701	12	,	,	PUNCT
gs-3799	701	13	there	there	PRON
gs-3799	701	14	is	be	VERB
gs-3799	701	15	still	still	ADV
gs-3799	701	16	promise	promise	NOUN
gs-3799	701	17	in	in	ADP
gs-3799	701	18	overcoming	overcome	VERB
gs-3799	701	19	these	these	DET
gs-3799	701	20	obstacles	obstacle	NOUN
gs-3799	701	21	.	.	PUNCT
gs-3799	702	1	ongoing	ongoing	ADJ
gs-3799	702	2	futuristic	futuristic	ADJ
gs-3799	702	3	approaches	approach	NOUN
gs-3799	702	4	and	and	CCONJ
gs-3799	702	5	the	the	DET
gs-3799	702	6	alliance	alliance	NOUN
gs-3799	702	7	of	of	ADP
gs-3799	702	8	multiple	multiple	ADJ
gs-3799	702	9	specialties	specialty	NOUN
gs-3799	702	10	have	have	AUX
gs-3799	702	11	given	give	VERB
gs-3799	702	12	closed	close	VERB
gs-3799	702	13	-	-	PUNCT
gs-3799	702	14	loop	loop	NOUN
gs-3799	702	15	cpb	cpb	PROPN
gs-3799	702	16	systems	system	NOUN
gs-3799	702	17	great	great	ADJ
gs-3799	702	18	potential	potential	NOUN
gs-3799	702	19	to	to	PART
gs-3799	702	20	become	become	VERB
gs-3799	702	21	an	an	DET
gs-3799	702	22	essential	essential	ADJ
gs-3799	702	23	aspect	aspect	NOUN
gs-3799	702	24	in	in	ADP
gs-3799	702	25	the	the	DET
gs-3799	702	26	field	field	NOUN
gs-3799	702	27	of	of	ADP
gs-3799	702	28	pediatric	pediatric	ADJ
gs-3799	702	29	cardiac	cardiac	ADJ
gs-3799	702	30	surgery	surgery	NOUN
gs-3799	702	31	.	.	PUNCT
gs-3799	703	1	besides	besides	SCONJ
gs-3799	703	2	aiding	aid	VERB
gs-3799	703	3	surgical	surgical	ADJ
gs-3799	703	4	care	care	NOUN
gs-3799	703	5	in	in	ADP
gs-3799	703	6	its	its	PRON
gs-3799	703	7	efforts	effort	NOUN
gs-3799	703	8	to	to	PART
gs-3799	703	9	become	become	VERB
gs-3799	703	10	more	more	ADV
gs-3799	703	11	secure	secure	ADJ
gs-3799	703	12	and	and	CCONJ
gs-3799	703	13	consistent	consistent	ADJ
gs-3799	703	14	,	,	PUNCT
gs-3799	703	15	this	this	DET
gs-3799	703	16	system	system	NOUN
gs-3799	703	17	has	have	AUX
gs-3799	703	18	opened	open	VERB
gs-3799	703	19	new	new	ADJ
gs-3799	703	20	doors	door	NOUN
gs-3799	703	21	to	to	PART
gs-3799	703	22	redefine	redefine	VERB
gs-3799	703	23	regular	regular	ADJ
gs-3799	703	24	perfusion	perfusion	NOUN
gs-3799	703	25	methods	method	NOUN
gs-3799	703	26	worldwide	worldwide	ADV
gs-3799	703	27	.	.	PUNCT
gs-3799	704	1	georgian	georgian	NOUN
gs-3799	704	2	scientists/	scientists/	NUM
gs-3799	704	3	.	.	PUNCT
gs-3799	705	1	7	7	NUM
gs-3799	705	2	n	n	PRON
gs-3799	705	3	2	2	NUM
gs-3799	705	4	,	,	PUNCT
gs-3799	705	5	2025	2025	NUM
gs-3799	705	6	415	415	NUM
gs-3799	705	7	this	this	DET
gs-3799	705	8	research	research	NOUN
gs-3799	705	9	provides	provide	VERB
gs-3799	705	10	a	a	DET
gs-3799	705	11	foundational	foundational	ADJ
gs-3799	705	12	roadmap	roadmap	NOUN
gs-3799	705	13	for	for	ADP
gs-3799	705	14	advancing	advance	VERB
gs-3799	705	15	intelligent	intelligent	ADJ
gs-3799	705	16	perfusion	perfusion	NOUN
gs-3799	705	17	.	.	PUNCT
gs-3799	706	1	priorities	priority	NOUN
gs-3799	706	2	include	include	VERB
gs-3799	706	3	conducting	conduct	VERB
gs-3799	706	4	multicenter	multicenter	ADJ
gs-3799	706	5	trials	trial	NOUN
gs-3799	706	6	across	across	ADP
gs-3799	706	7	diverse	diverse	ADJ
gs-3799	706	8	surgical	surgical	ADJ
gs-3799	706	9	populations	population	NOUN
gs-3799	706	10	,	,	PUNCT
gs-3799	706	11	developing	develop	VERB
gs-3799	706	12	ai	ai	PROPN
gs-3799	706	13	architectures	architecture	NOUN
gs-3799	706	14	trained	train	VERB
gs-3799	706	15	on	on	ADP
gs-3799	706	16	federated	federated	ADJ
gs-3799	706	17	datasets	dataset	NOUN
gs-3799	706	18	for	for	ADP
gs-3799	706	19	personalized	personalized	ADJ
gs-3799	706	20	control	control	NOUN
gs-3799	706	21	,	,	PUNCT
gs-3799	706	22	and	and	CCONJ
gs-3799	706	23	creating	create	VERB
gs-3799	706	24	regulatory	regulatory	ADJ
gs-3799	706	25	guidelines	guideline	NOUN
gs-3799	706	26	for	for	ADP
gs-3799	706	27	closedloop	closedloop	NOUN
gs-3799	706	28	safety	safety	NOUN
gs-3799	706	29	validation	validation	NOUN
gs-3799	706	30	.	.	PUNCT
gs-3799	707	1	collaborative	collaborative	ADJ
gs-3799	707	2	efforts	effort	NOUN
gs-3799	707	3	among	among	ADP
gs-3799	707	4	clinicians	clinician	NOUN
gs-3799	707	5	,	,	PUNCT
gs-3799	707	6	engineers	engineer	NOUN
gs-3799	707	7	,	,	PUNCT
gs-3799	707	8	and	and	CCONJ
gs-3799	707	9	policymakers	policymaker	NOUN
gs-3799	707	10	must	must	AUX
gs-3799	707	11	focus	focus	VERB
gs-3799	707	12	on	on	ADP
gs-3799	707	13	equitable	equitable	ADJ
gs-3799	707	14	implementation	implementation	NOUN
gs-3799	707	15	—	—	PUNCT
gs-3799	707	16	ensuring	ensure	VERB
gs-3799	707	17	cost	cost	NOUN
gs-3799	707	18	-	-	PUNCT
gs-3799	707	19	effective	effective	ADJ
gs-3799	707	20	,	,	PUNCT
gs-3799	707	21	modular	modular	ADJ
gs-3799	707	22	designs	design	NOUN
gs-3799	707	23	accessible	accessible	ADJ
gs-3799	707	24	in	in	ADP
gs-3799	707	25	resource	resource	NOUN
gs-3799	707	26	-	-	PUNCT
gs-3799	707	27	limited	limit	VERB
gs-3799	707	28	settings	setting	NOUN
gs-3799	707	29	—	—	PUNCT
gs-3799	707	30	while	while	SCONJ
gs-3799	707	31	establishing	establish	VERB
gs-3799	707	32	global	global	ADJ
gs-3799	707	33	registries	registry	NOUN
gs-3799	707	34	for	for	ADP
gs-3799	707	35	long	long	ADJ
gs-3799	707	36	-	-	PUNCT
gs-3799	707	37	term	term	NOUN
gs-3799	707	38	outcome	outcome	NOUN
gs-3799	707	39	surveillance	surveillance	NOUN
gs-3799	707	40	.	.	PUNCT
gs-3799	708	1	by	by	ADP
gs-3799	708	2	bridging	bridge	VERB
gs-3799	708	3	technological	technological	ADJ
gs-3799	708	4	innovation	innovation	NOUN
gs-3799	708	5	with	with	ADP
gs-3799	708	6	rigorous	rigorous	ADJ
gs-3799	708	7	clinical	clinical	ADJ
gs-3799	708	8	translation	translation	NOUN
gs-3799	708	9	,	,	PUNCT
gs-3799	708	10	closed	closed	ADJ
gs-3799	708	11	-	-	PUNCT
gs-3799	708	12	loop	loop	NOUN
gs-3799	708	13	cpb	cpb	NOUN
gs-3799	708	14	systems	system	NOUN
gs-3799	708	15	can	can	AUX
gs-3799	708	16	evolve	evolve	VERB
gs-3799	708	17	from	from	ADP
gs-3799	708	18	experimental	experimental	ADJ
gs-3799	708	19	tools	tool	NOUN
gs-3799	708	20	into	into	ADP
gs-3799	708	21	standardized	standardized	ADJ
gs-3799	708	22	therapeutic	therapeutic	ADJ
gs-3799	708	23	platforms	platform	NOUN
gs-3799	708	24	,	,	PUNCT
gs-3799	708	25	ultimately	ultimately	ADV
gs-3799	708	26	redefining	redefine	VERB
gs-3799	708	27	safety	safety	NOUN
gs-3799	708	28	and	and	CCONJ
gs-3799	708	29	efficacy	efficacy	NOUN
gs-3799	708	30	benchmarks	benchmark	NOUN
gs-3799	708	31	in	in	ADP
gs-3799	708	32	cardiac	cardiac	ADJ
gs-3799	708	33	surgery	surgery	NOUN
gs-3799	708	34	worldwide	worldwide	ADV
gs-3799	708	35	.	.	PUNCT
gs-3799	709	1	recommendations	recommendation	NOUN
gs-3799	709	2	to	to	PART
gs-3799	709	3	speed	speed	VERB
gs-3799	709	4	up	up	ADP
gs-3799	709	5	the	the	DET
gs-3799	709	6	maturing	mature	VERB
gs-3799	709	7	and	and	CCONJ
gs-3799	709	8	safe	safe	ADJ
gs-3799	709	9	approval	approval	NOUN
gs-3799	709	10	of	of	ADP
gs-3799	709	11	closed	closed	ADJ
gs-3799	709	12	-	-	PUNCT
gs-3799	709	13	loop	loop	NOUN
gs-3799	709	14	cpb	cpb	NOUN
gs-3799	709	15	systems	system	NOUN
gs-3799	709	16	in	in	ADP
gs-3799	709	17	pediatric	pediatric	ADJ
gs-3799	709	18	cardiac	cardiac	ADJ
gs-3799	709	19	supervision	supervision	NOUN
gs-3799	709	20	,	,	PUNCT
gs-3799	709	21	the	the	DET
gs-3799	709	22	following	follow	VERB
gs-3799	709	23	recommendations	recommendation	NOUN
gs-3799	709	24	are	be	AUX
gs-3799	709	25	put	put	VERB
gs-3799	709	26	forward	forward	ADV
gs-3799	709	27	:	:	PUNCT
gs-3799	709	28	fund	fund	NOUN
gs-3799	709	29	in	in	ADP
gs-3799	709	30	research	research	NOUN
gs-3799	709	31	and	and	CCONJ
gs-3799	709	32	progress	progress	NOUN
gs-3799	709	33	:	:	PUNCT
gs-3799	709	34	expanded	expand	VERB
gs-3799	709	35	investment	investment	NOUN
gs-3799	709	36	should	should	AUX
gs-3799	709	37	be	be	AUX
gs-3799	709	38	distributed	distribute	VERB
gs-3799	709	39	to	to	ADP
gs-3799	709	40	integrative	integrative	ADJ
gs-3799	709	41	multidisciplinary	multidisciplinary	ADJ
gs-3799	709	42	projects	project	NOUN
gs-3799	709	43	that	that	PRON
gs-3799	709	44	improve	improve	VERB
gs-3799	709	45	and	and	CCONJ
gs-3799	709	46	refine	refine	VERB
gs-3799	709	47	closed	closed	ADJ
gs-3799	709	48	-	-	PUNCT
gs-3799	709	49	loop	loop	NOUN
gs-3799	709	50	systems	system	NOUN
gs-3799	709	51	especially	especially	ADV
gs-3799	709	52	for	for	ADP
gs-3799	709	53	pediatric	pediatric	ADJ
gs-3799	709	54	and	and	CCONJ
gs-3799	709	55	neonatal	neonatal	ADJ
gs-3799	709	56	requests	request	NOUN
gs-3799	709	57	.	.	PUNCT
gs-3799	710	1	set	set	VERB
gs-3799	710	2	up	up	ADP
gs-3799	710	3	clinical	clinical	ADJ
gs-3799	710	4	trial	trial	NOUN
gs-3799	710	5	structures	structure	NOUN
gs-3799	710	6	:	:	PUNCT
gs-3799	710	7	multiple	multiple	ADJ
gs-3799	710	8	center	center	NOUN
gs-3799	710	9	trials	trial	NOUN
gs-3799	710	10	are	be	AUX
gs-3799	710	11	crucial	crucial	ADJ
gs-3799	710	12	to	to	PART
gs-3799	710	13	confirm	confirm	VERB
gs-3799	710	14	system	system	NOUN
gs-3799	710	15	execution	execution	NOUN
gs-3799	710	16	,	,	PUNCT
gs-3799	710	17	examine	examine	VERB
gs-3799	710	18	safety	safety	NOUN
gs-3799	710	19	results	result	NOUN
gs-3799	710	20	,	,	PUNCT
gs-3799	710	21	and	and	CCONJ
gs-3799	710	22	produce	produce	VERB
gs-3799	710	23	large	large	ADJ
gs-3799	710	24	data	datum	NOUN
gs-3799	710	25	values	value	NOUN
gs-3799	710	26	for	for	ADP
gs-3799	710	27	machine	machine	NOUN
gs-3799	710	28	learning	learning	NOUN
gs-3799	710	29	model	model	NOUN
gs-3799	710	30	clarification	clarification	NOUN
gs-3799	710	31	.	.	PUNCT
gs-3799	711	1	promote	promote	VERB
gs-3799	711	2	open	open	ADJ
gs-3799	711	3	data	datum	NOUN
gs-3799	711	4	distribution	distribution	NOUN
gs-3799	711	5	:	:	PUNCT
gs-3799	711	6	the	the	DET
gs-3799	711	7	formation	formation	NOUN
gs-3799	711	8	of	of	ADP
gs-3799	711	9	unidentified	unidentified	ADJ
gs-3799	711	10	pediatric	pediatric	ADJ
gs-3799	711	11	cpb	cpb	PROPN
gs-3799	711	12	information	information	NOUN
gs-3799	711	13	would	would	AUX
gs-3799	711	14	help	help	VERB
gs-3799	711	15	in	in	ADP
gs-3799	711	16	technique	technique	NOUN
gs-3799	711	17	development	development	NOUN
gs-3799	711	18	and	and	CCONJ
gs-3799	711	19	enable	enable	ADJ
gs-3799	711	20	researchers	researcher	NOUN
gs-3799	711	21	to	to	PART
gs-3799	711	22	model	model	VERB
gs-3799	711	23	various	various	ADJ
gs-3799	711	24	physiological	physiological	ADJ
gs-3799	711	25	states	state	NOUN
gs-3799	711	26	.	.	PUNCT
gs-3799	712	1	evolve	evolve	VERB
gs-3799	712	2	modular	modular	ADJ
gs-3799	712	3	,	,	PUNCT
gs-3799	712	4	compatible	compatible	ADJ
gs-3799	712	5	designs	design	NOUN
gs-3799	712	6	:	:	PUNCT
gs-3799	712	7	systems	system	NOUN
gs-3799	712	8	should	should	AUX
gs-3799	712	9	be	be	AUX
gs-3799	712	10	created	create	VERB
gs-3799	712	11	for	for	ADP
gs-3799	712	12	excellent	excellent	ADJ
gs-3799	712	13	combination	combination	NOUN
gs-3799	712	14	with	with	ADP
gs-3799	712	15	existing	exist	VERB
gs-3799	712	16	observing	observing	NOUN
gs-3799	712	17	and	and	CCONJ
gs-3799	712	18	cpb	cpb	NOUN
gs-3799	712	19	equipment	equipment	NOUN
gs-3799	712	20	,	,	PUNCT
gs-3799	712	21	magnifying	magnify	VERB
gs-3799	712	22	adoption	adoption	NOUN
gs-3799	712	23	and	and	CCONJ
gs-3799	712	24	serviceability	serviceability	NOUN
gs-3799	712	25	.	.	PUNCT
gs-3799	713	1	nurture	nurture	ADJ
gs-3799	713	2	ethical	ethical	ADJ
gs-3799	713	3	errors	error	NOUN
gs-3799	713	4	and	and	CCONJ
gs-3799	713	5	regulatory	regulatory	ADJ
gs-3799	713	6	participation	participation	NOUN
gs-3799	713	7	:	:	PUNCT
gs-3799	713	8	early	early	ADJ
gs-3799	713	9	collaboration	collaboration	NOUN
gs-3799	713	10	of	of	ADP
gs-3799	713	11	ethical	ethical	ADJ
gs-3799	713	12	boards	board	NOUN
gs-3799	713	13	and	and	CCONJ
gs-3799	713	14	regulatory	regulatory	ADJ
gs-3799	713	15	agencies	agency	NOUN
gs-3799	713	16	will	will	AUX
gs-3799	713	17	push	push	VERB
gs-3799	713	18	to	to	PART
gs-3799	713	19	define	define	VERB
gs-3799	713	20	clinical	clinical	ADJ
gs-3799	713	21	peaks	peak	NOUN
gs-3799	713	22	,	,	PUNCT
gs-3799	713	23	safety	safety	NOUN
gs-3799	713	24	mechanisms	mechanism	NOUN
gs-3799	713	25	,	,	PUNCT
gs-3799	713	26	and	and	CCONJ
gs-3799	713	27	human	human	ADJ
gs-3799	713	28	error	error	NOUN
gs-3799	713	29	protocols	protocol	NOUN
gs-3799	713	30	.	.	PUNCT
gs-3799	714	1	incorporate	incorporate	VERB
gs-3799	714	2	with	with	ADP
gs-3799	714	3	training	training	NOUN
gs-3799	714	4	programs	program	NOUN
gs-3799	714	5	:	:	PUNCT
gs-3799	714	6	medical	medical	ADJ
gs-3799	714	7	and	and	CCONJ
gs-3799	714	8	perfusion	perfusion	NOUN
gs-3799	714	9	studies	study	NOUN
gs-3799	714	10	curricula	curriculum	NOUN
gs-3799	714	11	should	should	AUX
gs-3799	714	12	start	start	VERB
gs-3799	714	13	to	to	PART
gs-3799	714	14	combine	combine	VERB
gs-3799	714	15	knowledge	knowledge	NOUN
gs-3799	714	16	of	of	ADP
gs-3799	714	17	automated	automate	VERB
gs-3799	714	18	systems	system	NOUN
gs-3799	714	19	,	,	PUNCT
gs-3799	714	20	simulation	simulation	NOUN
gs-3799	714	21	training	training	NOUN
gs-3799	714	22	,	,	PUNCT
gs-3799	714	23	and	and	CCONJ
gs-3799	714	24	ai	ai	VERB
gs-3799	714	25	in	in	ADP
gs-3799	714	26	perfusion	perfusion	NOUN
gs-3799	714	27	care	care	NOUN
gs-3799	714	28	.	.	PUNCT
gs-3799	715	1	aid	aid	VERB
gs-3799	715	2	scalable	scalable	ADJ
gs-3799	715	3	resolutions	resolution	NOUN
gs-3799	715	4	for	for	ADP
gs-3799	715	5	lmics	lmic	NOUN
gs-3799	715	6	:	:	PUNCT
gs-3799	715	7	developing	develop	VERB
gs-3799	715	8	efficacy	efficacy	NOUN
gs-3799	715	9	in	in	ADP
gs-3799	715	10	costs	cost	NOUN
gs-3799	715	11	,	,	PUNCT
gs-3799	715	12	flexible	flexible	ADJ
gs-3799	715	13	systems	system	NOUN
gs-3799	715	14	with	with	ADP
gs-3799	715	15	modular	modular	ADJ
gs-3799	715	16	elements	element	NOUN
gs-3799	715	17	may	may	AUX
gs-3799	715	18	enable	enable	VERB
gs-3799	715	19	adoption	adoption	NOUN
gs-3799	715	20	in	in	ADP
gs-3799	715	21	lowand	lowand	ADJ
gs-3799	715	22	middle	middle	ADJ
gs-3799	715	23	-	-	PUNCT
gs-3799	715	24	earning	earn	VERB
gs-3799	715	25	countries	country	NOUN
gs-3799	715	26	(	(	PUNCT
gs-3799	715	27	lmics	lmic	NOUN
gs-3799	715	28	)	)	PUNCT
gs-3799	715	29	,	,	PUNCT
gs-3799	715	30	where	where	SCONJ
gs-3799	715	31	availability	availability	NOUN
gs-3799	715	32	to	to	ADP
gs-3799	715	33	pediatric	pediatric	ADJ
gs-3799	715	34	cardiac	cardiac	ADJ
gs-3799	715	35	surgery	surgery	NOUN
gs-3799	715	36	rests	rest	VERB
gs-3799	715	37	in	in	ADP
gs-3799	715	38	short	short	ADJ
gs-3799	715	39	supply	supply	NOUN
gs-3799	715	40	.	.	PUNCT
gs-3799	716	1	record	record	NOUN
gs-3799	716	2	long	long	ADJ
gs-3799	716	3	-	-	PUNCT
gs-3799	716	4	term	term	NOUN
gs-3799	716	5	effects	effect	NOUN
gs-3799	716	6	:	:	PUNCT
gs-3799	716	7	after	after	ADP
gs-3799	716	8	intraoperative	intraoperative	ADJ
gs-3799	716	9	frameworks	framework	NOUN
gs-3799	716	10	,	,	PUNCT
gs-3799	716	11	systems	system	NOUN
gs-3799	716	12	should	should	AUX
gs-3799	716	13	be	be	AUX
gs-3799	716	14	assessed	assess	VERB
gs-3799	716	15	and	and	CCONJ
gs-3799	716	16	judged	judge	VERB
gs-3799	716	17	for	for	ADP
gs-3799	716	18	their	their	PRON
gs-3799	716	19	influence	influence	NOUN
gs-3799	716	20	on	on	ADP
gs-3799	716	21	lasting	last	VERB
gs-3799	716	22	neurodevelopmental	neurodevelopmental	ADJ
gs-3799	716	23	and	and	CCONJ
gs-3799	716	24	physiological	physiological	ADJ
gs-3799	716	25	results	result	NOUN
gs-3799	716	26	in	in	ADP
gs-3799	716	27	children	child	NOUN
gs-3799	716	28	going	go	VERB
gs-3799	716	29	through	through	ADP
gs-3799	716	30	cardiac	cardiac	ADJ
gs-3799	716	31	surgery	surgery	NOUN
gs-3799	716	32	.	.	PUNCT
gs-3799	717	1	hospital	hospital	NOUN
gs-3799	717	2	administrators	administrator	NOUN
gs-3799	717	3	and	and	CCONJ
gs-3799	717	4	funding	funding	NOUN
gs-3799	717	5	agencies	agency	NOUN
gs-3799	717	6	must	must	AUX
gs-3799	717	7	invest	invest	VERB
gs-3799	717	8	in	in	ADP
gs-3799	717	9	perfusionist	perfusionist	NOUN
gs-3799	717	10	training	training	NOUN
gs-3799	717	11	programs	program	NOUN
gs-3799	717	12	centered	center	VERB
gs-3799	717	13	on	on	ADP
gs-3799	717	14	closed	closed	ADJ
gs-3799	717	15	-	-	PUNCT
gs-3799	717	16	loop	loop	NOUN
gs-3799	717	17	system	system	NOUN
gs-3799	717	18	supervision	supervision	NOUN
gs-3799	717	19	,	,	PUNCT
gs-3799	717	20	crisis	crisis	NOUN
gs-3799	717	21	management	management	NOUN
gs-3799	717	22	for	for	ADP
gs-3799	717	23	automation	automation	NOUN
gs-3799	717	24	failures	failure	NOUN
gs-3799	717	25	,	,	PUNCT
gs-3799	717	26	and	and	CCONJ
gs-3799	717	27	datadriven	datadriven	ADJ
gs-3799	717	28	decision	decision	NOUN
gs-3799	717	29	support	support	NOUN
gs-3799	717	30	,	,	PUNCT
gs-3799	717	31	while	while	SCONJ
gs-3799	717	32	supporting	support	VERB
gs-3799	717	33	cost	cost	NOUN
gs-3799	717	34	-	-	PUNCT
gs-3799	717	35	benefit	benefit	NOUN
gs-3799	717	36	analyses	analysis	NOUN
gs-3799	717	37	that	that	PRON
gs-3799	717	38	quantify	quantify	VERB
gs-3799	717	39	long	long	ADJ
gs-3799	717	40	-	-	PUNCT
gs-3799	717	41	term	term	NOUN
gs-3799	717	42	savings	saving	NOUN
gs-3799	717	43	from	from	ADP
gs-3799	717	44	reduced	reduced	ADJ
gs-3799	717	45	complications	complication	NOUN
gs-3799	717	46	and	and	CCONJ
gs-3799	717	47	resource	resource	NOUN
gs-3799	717	48	utilization	utilization	NOUN
gs-3799	717	49	.	.	PUNCT
gs-3799	718	1	globally	globally	ADV
gs-3799	718	2	,	,	PUNCT
gs-3799	718	3	health	health	NOUN
gs-3799	718	4	policy	policy	NOUN
gs-3799	718	5	organizations	organization	NOUN
gs-3799	718	6	(	(	PUNCT
gs-3799	718	7	who	who	PRON
gs-3799	718	8	,	,	PUNCT
gs-3799	718	9	world	world	PROPN
gs-3799	718	10	bank	bank	PROPN
gs-3799	718	11	)	)	PUNCT
gs-3799	718	12	should	should	AUX
gs-3799	718	13	incentivize	incentivize	VERB
gs-3799	718	14	modular	modular	ADJ
gs-3799	718	15	,	,	PUNCT
gs-3799	718	16	low	low	ADJ
gs-3799	718	17	-	-	PUNCT
gs-3799	718	18	cost	cost	NOUN
gs-3799	718	19	closed	close	VERB
gs-3799	718	20	-	-	PUNCT
gs-3799	718	21	loop	loop	NOUN
gs-3799	718	22	solutions	solution	NOUN
gs-3799	718	23	for	for	ADP
gs-3799	718	24	resource	resource	NOUN
gs-3799	718	25	-	-	PUNCT
gs-3799	718	26	constrained	constrain	VERB
gs-3799	718	27	settings	setting	NOUN
gs-3799	718	28	,	,	PUNCT
gs-3799	718	29	such	such	ADJ
gs-3799	718	30	as	as	ADP
gs-3799	718	31	battery	battery	NOUN
gs-3799	718	32	-	-	PUNCT
gs-3799	718	33	operated	operate	VERB
gs-3799	718	34	cpb	cpb	NOUN
gs-3799	718	35	units	unit	NOUN
gs-3799	718	36	with	with	ADP
gs-3799	718	37	simplified	simplified	ADJ
gs-3799	718	38	ai	ai	NOUN
gs-3799	718	39	interfaces	interface	NOUN
gs-3799	718	40	.	.	PUNCT
gs-3799	719	1	finally	finally	ADV
gs-3799	719	2	,	,	PUNCT
gs-3799	719	3	journals	journal	NOUN
gs-3799	719	4	and	and	CCONJ
gs-3799	719	5	conferences	conference	NOUN
gs-3799	719	6	must	must	AUX
gs-3799	719	7	prioritize	prioritize	VERB
gs-3799	719	8	publication	publication	NOUN
gs-3799	719	9	of	of	ADP
gs-3799	719	10	negative	negative	ADJ
gs-3799	719	11	or	or	CCONJ
gs-3799	719	12	equivocal	equivocal	ADJ
gs-3799	719	13	trial	trial	NOUN
gs-3799	719	14	outcomes	outcome	NOUN
gs-3799	719	15	to	to	PART
gs-3799	719	16	prevent	prevent	VERB
gs-3799	719	17	evidence	evidence	NOUN
gs-3799	719	18	georgian	georgian	NOUN
gs-3799	719	19	scientists/	scientists/	NUM
gs-3799	719	20	.	.	PUNCT
gs-3799	720	1	7	7	NUM
gs-3799	720	2	n	n	PRON
gs-3799	720	3	2	2	NUM
gs-3799	720	4	,	,	PUNCT
gs-3799	720	5	2025	2025	NUM
gs-3799	720	6	416	416	NUM
gs-3799	720	7	distortion	distortion	NOUN
gs-3799	720	8	and	and	CCONJ
gs-3799	720	9	illuminate	illuminate	VERB
gs-3799	720	10	persistent	persistent	ADJ
gs-3799	720	11	engineering	engineering	NOUN
gs-3799	720	12	challenges	challenge	NOUN
gs-3799	720	13	.	.	PUNCT
gs-3799	721	1	collectively	collectively	ADV
gs-3799	721	2	,	,	PUNCT
gs-3799	721	3	these	these	DET
gs-3799	721	4	actions	action	NOUN
gs-3799	721	5	will	will	AUX
gs-3799	721	6	forge	forge	VERB
gs-3799	721	7	a	a	DET
gs-3799	721	8	resilient	resilient	ADJ
gs-3799	721	9	ecosystem	ecosystem	NOUN
gs-3799	721	10	for	for	ADP
gs-3799	721	11	intelligent	intelligent	ADJ
gs-3799	721	12	perfusion	perfusion	NOUN
gs-3799	721	13	—	—	PUNCT
gs-3799	721	14	one	one	NUM
gs-3799	721	15	that	that	PRON
gs-3799	721	16	prioritizes	prioritize	VERB
gs-3799	721	17	patient	patient	ADJ
gs-3799	721	18	safety	safety	NOUN
gs-3799	721	19	,	,	PUNCT
gs-3799	721	20	clinician	clinician	NOUN
gs-3799	721	21	trust	trust	NOUN
gs-3799	721	22	,	,	PUNCT
gs-3799	721	23	and	and	CCONJ
gs-3799	721	24	equitable	equitable	ADJ
gs-3799	721	25	innovation	innovation	NOUN
gs-3799	721	26	diffusion	diffusion	NOUN
gs-3799	721	27	.	.	PUNCT
gs-3799	722	1	references	reference	NOUN
gs-3799	722	2	1	1	NUM
gs-3799	722	3	.	.	PUNCT
gs-3799	723	1	xie	xie	PROPN
gs-3799	723	2	,	,	PUNCT
gs-3799	723	3	y.	y.	PROPN
gs-3799	723	4	,	,	PUNCT
gs-3799	723	5	wang	wang	PROPN
gs-3799	723	6	,	,	PUNCT
gs-3799	723	7	y.	y.	PROPN
gs-3799	723	8	,	,	PUNCT
gs-3799	723	9	zhang	zhang	PROPN
gs-3799	723	10	,	,	PUNCT
gs-3799	723	11	l.	l.	PROPN
gs-3799	723	12	,	,	PUNCT
gs-3799	723	13	&	&	CCONJ
gs-3799	723	14	li	li	PROPN
gs-3799	723	15	,	,	PUNCT
gs-3799	723	16	h.	h.	PROPN
gs-3799	723	17	(	(	PUNCT
gs-3799	723	18	2024	2024	NUM
gs-3799	723	19	)	)	PUNCT
gs-3799	723	20	.	.	PUNCT
gs-3799	724	1	utilizing	utilize	VERB
gs-3799	724	2	mesenteric	mesenteric	ADJ
gs-3799	724	3	near	near	ADV
gs-3799	724	4	-	-	PUNCT
gs-3799	724	5	infrared	infrared	ADJ
gs-3799	724	6	reflectance	reflectance	NOUN
gs-3799	724	7	spectroscopy	spectroscopy	VERB
gs-3799	724	8	to	to	PART
gs-3799	724	9	predict	predict	VERB
gs-3799	724	10	gastrointestinal	gastrointestinal	ADJ
gs-3799	724	11	complication	complication	NOUN
gs-3799	724	12	risks	risk	NOUN
gs-3799	724	13	and	and	CCONJ
gs-3799	724	14	optimize	optimize	VERB
gs-3799	724	15	feeding	feeding	NOUN
gs-3799	724	16	strategies	strategy	NOUN
gs-3799	724	17	in	in	ADP
gs-3799	724	18	infants	infant	NOUN
gs-3799	724	19	undergoing	undergo	VERB
gs-3799	724	20	cardiac	cardiac	ADJ
gs-3799	724	21	surgery	surgery	NOUN
gs-3799	724	22	.	.	PUNCT
gs-3799	725	1	pediatric	pediatric	ADJ
gs-3799	725	2	investigation	investigation	NOUN
gs-3799	725	3	,	,	PUNCT
gs-3799	725	4	8(1	8(1	NOUN
gs-3799	725	5	)	)	PUNCT
gs-3799	725	6	,	,	PUNCT
gs-3799	725	7	e12437	e12437	PROPN
gs-3799	725	8	.	.	NOUN
gs-3799	725	9	2	2	NUM
gs-3799	725	10	.	.	X
gs-3799	726	1	abdul	abdul	PROPN
gs-3799	726	2	-	-	PUNCT
gs-3799	726	3	khaliq	khaliq	PROPN
gs-3799	726	4	,	,	PUNCT
gs-3799	726	5	h.	h.	PROPN
gs-3799	726	6	,	,	PUNCT
gs-3799	726	7	schubert	schubert	PROPN
gs-3799	726	8	,	,	PUNCT
gs-3799	726	9	s.	s.	PROPN
gs-3799	726	10	,	,	PUNCT
gs-3799	726	11	troitzsch	troitzsch	PROPN
gs-3799	726	12	,	,	PUNCT
gs-3799	726	13	d.	d.	PROPN
gs-3799	726	14	,	,	PUNCT
gs-3799	726	15	huebler	huebler	NOUN
gs-3799	726	16	,	,	PUNCT
gs-3799	726	17	m.	m.	NOUN
gs-3799	726	18	,	,	PUNCT
gs-3799	726	19	boettcher	boettcher	PROPN
gs-3799	726	20	,	,	PUNCT
gs-3799	726	21	w.	w.	PROPN
gs-3799	726	22	,	,	PUNCT
gs-3799	726	23	baur	baur	PROPN
gs-3799	726	24	,	,	PUNCT
gs-3799	726	25	m.	m.	NOUN
gs-3799	726	26	o.	o.	PROPN
gs-3799	726	27	,	,	PUNCT
gs-3799	726	28	&	&	CCONJ
gs-3799	726	29	lange	lange	PROPN
gs-3799	726	30	,	,	PUNCT
gs-3799	726	31	p.	p.	PROPN
gs-3799	726	32	e.	e.	PROPN
gs-3799	727	1	(	(	PUNCT
gs-3799	727	2	2013	2013	NUM
gs-3799	727	3	)	)	PUNCT
gs-3799	727	4	.	.	PUNCT
gs-3799	728	1	cerebral	cerebral	ADJ
gs-3799	728	2	near	near	ADV
gs-3799	728	3	-	-	PUNCT
gs-3799	728	4	infrared	infrared	ADJ
gs-3799	728	5	spectroscopy	spectroscopy	NOUN
gs-3799	728	6	correlates	correlate	VERB
gs-3799	728	7	to	to	ADP
gs-3799	728	8	vital	vital	ADJ
gs-3799	728	9	parameters	parameter	NOUN
gs-3799	728	10	during	during	ADP
gs-3799	728	11	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	728	12	bypass	bypass	NOUN
gs-3799	728	13	surgery	surgery	NOUN
gs-3799	728	14	in	in	ADP
gs-3799	728	15	children	child	NOUN
gs-3799	728	16	.	.	PUNCT
gs-3799	729	1	pediatric	pediatric	ADJ
gs-3799	729	2	cardiology	cardiology	NOUN
gs-3799	729	3	,	,	PUNCT
gs-3799	729	4	34(5	34(5	PROPN
gs-3799	729	5	)	)	PUNCT
gs-3799	729	6	,	,	PUNCT
gs-3799	729	7	1109–1115	1109–1115	NUM
gs-3799	729	8	.	.	PUNCT
gs-3799	730	1	3	3	X
gs-3799	730	2	.	.	X
gs-3799	730	3	wang	wang	PROPN
gs-3799	730	4	,	,	PUNCT
gs-3799	730	5	d.	d.	PROPN
gs-3799	730	6	,	,	PUNCT
gs-3799	730	7	zhou	zhou	PROPN
gs-3799	730	8	,	,	PUNCT
gs-3799	730	9	x.	x.	PROPN
gs-3799	730	10	,	,	PUNCT
gs-3799	730	11	sumpter	sumpter	PROPN
gs-3799	730	12	,	,	PUNCT
gs-3799	730	13	l.	l.	PROPN
gs-3799	730	14	r.	r.	PROPN
gs-3799	730	15	,	,	PUNCT
gs-3799	730	16	ballard	ballard	PROPN
gs-3799	730	17	-	-	PUNCT
gs-3799	730	18	croft	croft	PROPN
gs-3799	730	19	,	,	PUNCT
gs-3799	730	20	c.	c.	PROPN
gs-3799	730	21	,	,	PUNCT
gs-3799	730	22	&	&	CCONJ
gs-3799	730	23	zwischenberger	zwischenberger	PROPN
gs-3799	730	24	,	,	PUNCT
gs-3799	730	25	j.	j.	PROPN
gs-3799	730	26	b.	b.	PROPN
gs-3799	730	27	(	(	PUNCT
gs-3799	730	28	2015	2015	NUM
gs-3799	730	29	)	)	PUNCT
gs-3799	730	30	.	.	PUNCT
gs-3799	731	1	continuous	continuous	ADJ
gs-3799	731	2	metabolic	metabolic	NOUN
gs-3799	731	3	monitoring	monitoring	NOUN
gs-3799	731	4	in	in	ADP
gs-3799	731	5	infant	infant	ADJ
gs-3799	731	6	cardiac	cardiac	ADJ
gs-3799	731	7	surgery	surgery	NOUN
gs-3799	731	8	:	:	PUNCT
gs-3799	731	9	toward	toward	ADP
gs-3799	731	10	an	an	DET
gs-3799	731	11	individualized	individualized	ADJ
gs-3799	731	12	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	731	13	bypass	bypass	NOUN
gs-3799	731	14	strategy	strategy	NOUN
gs-3799	731	15	.	.	PUNCT
gs-3799	732	1	artificial	artificial	ADJ
gs-3799	732	2	organs	organ	NOUN
gs-3799	732	3	,	,	PUNCT
gs-3799	732	4	39(12	39(12	NUM
gs-3799	732	5	)	)	PUNCT
gs-3799	732	6	,	,	PUNCT
gs-3799	732	7	1050–1056	1050–1056	NUM
gs-3799	732	8	.	.	PUNCT
gs-3799	733	1	https://doi.org/10.1111/aor.12501	https://doi.org/10.1111/aor.12501	NOUN
gs-3799	733	2	.	.	PUNCT
gs-3799	734	1	4	4	X
gs-3799	734	2	.	.	X
gs-3799	734	3	ersoy	ersoy	PROPN
gs-3799	734	4	,	,	PUNCT
gs-3799	734	5	o.	o.	PROPN
gs-3799	734	6	,	,	PUNCT
gs-3799	734	7	yildirim	yildirim	PROPN
gs-3799	734	8	,	,	PUNCT
gs-3799	734	9	m.	m.	PROPN
gs-3799	734	10	,	,	PUNCT
gs-3799	734	11	yildirim	yildirim	PROPN
gs-3799	734	12	,	,	PUNCT
gs-3799	734	13	a.	a.	PROPN
gs-3799	734	14	,	,	PUNCT
gs-3799	734	15	&	&	CCONJ
gs-3799	734	16	yavuz	yavuz	PROPN
gs-3799	734	17	,	,	PUNCT
gs-3799	734	18	s.	s.	PROPN
gs-3799	734	19	(	(	PUNCT
gs-3799	734	20	2012	2012	NUM
gs-3799	734	21	)	)	PUNCT
gs-3799	734	22	.	.	PUNCT
gs-3799	735	1	cerebral	cerebral	ADJ
gs-3799	735	2	perfusion	perfusion	NOUN
gs-3799	735	3	during	during	ADP
gs-3799	735	4	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	735	5	bypass	bypass	NOUN
gs-3799	735	6	in	in	ADP
gs-3799	735	7	children	child	NOUN
gs-3799	735	8	:	:	PUNCT
gs-3799	735	9	correlations	correlation	NOUN
gs-3799	735	10	between	between	ADP
gs-3799	735	11	near	near	ADV
gs-3799	735	12	-	-	PUNCT
gs-3799	735	13	infrared	infrared	ADJ
gs-3799	735	14	spectroscopy	spectroscopy	NOUN
gs-3799	735	15	,	,	PUNCT
gs-3799	735	16	temperature	temperature	NOUN
gs-3799	735	17	,	,	PUNCT
gs-3799	735	18	lactate	lactate	NOUN
gs-3799	735	19	,	,	PUNCT
gs-3799	735	20	pump	pump	NOUN
gs-3799	735	21	flow	flow	NOUN
gs-3799	735	22	,	,	PUNCT
gs-3799	735	23	and	and	CCONJ
gs-3799	735	24	blood	blood	NOUN
gs-3799	735	25	pressure	pressure	NOUN
gs-3799	735	26	.	.	PUNCT
gs-3799	736	1	perfusion	perfusion	NOUN
gs-3799	736	2	,	,	PUNCT
gs-3799	736	3	27(6	27(6	NUM
gs-3799	736	4	)	)	PUNCT
gs-3799	736	5	,	,	PUNCT
gs-3799	736	6	487–493	487–493	NUM
gs-3799	736	7	.	.	PUNCT
gs-3799	737	1	5	5	NUM
gs-3799	737	2	.	.	X
gs-3799	737	3	zhang	zhang	PROPN
gs-3799	737	4	,	,	PUNCT
gs-3799	737	5	y.	y.	PROPN
gs-3799	737	6	,	,	PUNCT
gs-3799	737	7	li	li	PROPN
gs-3799	737	8	,	,	PUNCT
gs-3799	737	9	x.	x.	PROPN
gs-3799	737	10	,	,	PUNCT
gs-3799	737	11	wang	wang	PROPN
gs-3799	737	12	,	,	PUNCT
gs-3799	737	13	y.	y.	PROPN
gs-3799	737	14	,	,	PUNCT
gs-3799	737	15	&	&	CCONJ
gs-3799	737	16	liu	liu	PROPN
gs-3799	737	17	,	,	PUNCT
gs-3799	737	18	y.	y.	PROPN
gs-3799	737	19	(	(	PUNCT
gs-3799	737	20	2025	2025	NUM
gs-3799	737	21	)	)	PUNCT
gs-3799	737	22	.	.	PUNCT
gs-3799	738	1	goal	goal	NOUN
gs-3799	738	2	-	-	PUNCT
gs-3799	738	3	directed	direct	VERB
gs-3799	738	4	perfusion	perfusion	NOUN
gs-3799	738	5	to	to	PART
gs-3799	738	6	reduce	reduce	VERB
gs-3799	738	7	acute	acute	NOUN
gs-3799	738	8	kidney	kidney	NOUN
gs-3799	738	9	injury	injury	NOUN
gs-3799	738	10	after	after	ADP
gs-3799	738	11	pediatric	pediatric	ADJ
gs-3799	738	12	cardiac	cardiac	ADJ
gs-3799	738	13	operation	operation	NOUN
gs-3799	738	14	:	:	PUNCT
gs-3799	738	15	a	a	DET
gs-3799	738	16	randomized	randomized	ADJ
gs-3799	738	17	controlled	control	VERB
gs-3799	738	18	trial	trial	NOUN
gs-3799	738	19	.	.	PUNCT
gs-3799	739	1	the	the	DET
gs-3799	739	2	annals	annal	NOUN
gs-3799	739	3	of	of	ADP
gs-3799	739	4	thoracic	thoracic	NOUN
gs-3799	739	5	surgery	surgery	NOUN
gs-3799	739	6	,	,	PUNCT
gs-3799	739	7	119(2	119(2	NUM
gs-3799	739	8	)	)	PUNCT
gs-3799	739	9	,	,	PUNCT
gs-3799	739	10	456–463	456–463	NUM
gs-3799	739	11	.	.	NOUN
gs-3799	739	12	6	6	NUM
gs-3799	739	13	.	.	X
gs-3799	740	1	liu	liu	PROPN
gs-3799	740	2	,	,	PUNCT
gs-3799	740	3	h.	h.	PROPN
gs-3799	740	4	,	,	PUNCT
gs-3799	740	5	wang	wang	PROPN
gs-3799	740	6	,	,	PUNCT
gs-3799	740	7	z.	z.	PROPN
gs-3799	740	8	,	,	PUNCT
gs-3799	740	9	zhang	zhang	PROPN
gs-3799	740	10	,	,	PUNCT
gs-3799	740	11	l.	l.	PROPN
gs-3799	740	12	,	,	PUNCT
gs-3799	740	13	&	&	CCONJ
gs-3799	740	14	chen	chen	PROPN
gs-3799	740	15	,	,	PUNCT
gs-3799	740	16	y.	y.	PROPN
gs-3799	740	17	(	(	PUNCT
gs-3799	740	18	2010	2010	NUM
gs-3799	740	19	)	)	PUNCT
gs-3799	740	20	.	.	PUNCT
gs-3799	741	1	clinical	clinical	ADJ
gs-3799	741	2	real	real	ADJ
gs-3799	741	3	-	-	PUNCT
gs-3799	741	4	time	time	NOUN
gs-3799	741	5	monitoring	monitoring	NOUN
gs-3799	741	6	of	of	ADP
gs-3799	741	7	gaseous	gaseous	ADJ
gs-3799	741	8	microemboli	microemboli	NOUN
gs-3799	741	9	in	in	ADP
gs-3799	741	10	pediatric	pediatric	ADJ
gs-3799	741	11	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	741	12	bypass	bypass	NOUN
gs-3799	741	13	.	.	PUNCT
gs-3799	742	1	perfusion	perfusion	PROPN
gs-3799	742	2	,	,	PUNCT
gs-3799	742	3	25(1	25(1	NUM
gs-3799	742	4	)	)	PUNCT
gs-3799	742	5	,	,	PUNCT
gs-3799	742	6	15–20	15–20	NUM
gs-3799	742	7	.	.	NOUN
gs-3799	743	1	7	7	X
gs-3799	743	2	.	.	X
gs-3799	743	3	dent	dent	NOUN
gs-3799	743	4	,	,	PUNCT
gs-3799	743	5	c.	c.	PROPN
gs-3799	743	6	l.	l.	PROPN
gs-3799	743	7	,	,	PUNCT
gs-3799	743	8	spaeth	spaeth	PROPN
gs-3799	743	9	,	,	PUNCT
gs-3799	743	10	j.	j.	PROPN
gs-3799	743	11	p.	p.	PROPN
gs-3799	743	12	,	,	PUNCT
gs-3799	743	13	jones	jones	PROPN
gs-3799	743	14	,	,	PUNCT
gs-3799	743	15	b.	b.	PROPN
gs-3799	743	16	v.	v.	PROPN
gs-3799	743	17	,	,	PUNCT
gs-3799	743	18	&	&	CCONJ
gs-3799	743	19	bissler	bissler	PROPN
gs-3799	743	20	,	,	PUNCT
gs-3799	743	21	j.	j.	PROPN
gs-3799	743	22	j.	j.	PROPN
gs-3799	743	23	(	(	PUNCT
gs-3799	743	24	2013	2013	NUM
gs-3799	743	25	)	)	PUNCT
gs-3799	743	26	.	.	PUNCT
gs-3799	744	1	urinary	urinary	ADJ
gs-3799	744	2	biomarkers	biomarker	NOUN
gs-3799	744	3	and	and	CCONJ
gs-3799	744	4	renal	renal	ADJ
gs-3799	744	5	nearinfrared	nearinfrared	ADJ
gs-3799	744	6	spectroscopy	spectroscopy	NOUN
gs-3799	744	7	predict	predict	VERB
gs-3799	744	8	intensive	intensive	ADJ
gs-3799	744	9	care	care	NOUN
gs-3799	744	10	unit	unit	NOUN
gs-3799	744	11	outcomes	outcome	NOUN
gs-3799	744	12	after	after	ADP
gs-3799	744	13	cardiac	cardiac	ADJ
gs-3799	744	14	surgery	surgery	NOUN
gs-3799	744	15	in	in	ADP
gs-3799	744	16	infants	infant	NOUN
gs-3799	744	17	younger	young	ADJ
gs-3799	744	18	than	than	ADP
gs-3799	744	19	6	6	NUM
gs-3799	744	20	months	month	NOUN
gs-3799	744	21	of	of	ADP
gs-3799	744	22	age	age	NOUN
gs-3799	744	23	.	.	PUNCT
gs-3799	745	1	the	the	DET
gs-3799	745	2	journal	journal	NOUN
gs-3799	745	3	of	of	ADP
gs-3799	745	4	thoracic	thoracic	NOUN
gs-3799	745	5	and	and	CCONJ
gs-3799	745	6	cardiovascular	cardiovascular	ADJ
gs-3799	745	7	surgery	surgery	NOUN
gs-3799	745	8	,	,	PUNCT
gs-3799	745	9	146(4	146(4	NUM
gs-3799	745	10	)	)	PUNCT
gs-3799	745	11	,	,	PUNCT
gs-3799	745	12	861–867	861–867	NUM
gs-3799	745	13	.	.	PUNCT
gs-3799	746	1	8	8	NUM
gs-3799	746	2	.	.	PUNCT
gs-3799	747	1	li	li	PROPN
gs-3799	747	2	,	,	PUNCT
gs-3799	747	3	j.	j.	PROPN
gs-3799	747	4	,	,	PUNCT
gs-3799	747	5	zhang	zhang	PROPN
gs-3799	747	6	,	,	PUNCT
gs-3799	747	7	h.	h.	PROPN
gs-3799	747	8	,	,	PUNCT
gs-3799	747	9	&	&	CCONJ
gs-3799	747	10	wang	wang	PROPN
gs-3799	747	11	,	,	PUNCT
gs-3799	747	12	q.	q.	PROPN
gs-3799	747	13	(	(	PUNCT
gs-3799	747	14	2025	2025	NUM
gs-3799	747	15	)	)	PUNCT
gs-3799	747	16	.	.	PUNCT
gs-3799	748	1	effect	effect	NOUN
gs-3799	748	2	of	of	ADP
gs-3799	748	3	near	near	ADV
gs-3799	748	4	-	-	PUNCT
gs-3799	748	5	infrared	infrared	ADJ
gs-3799	748	6	spectroscopy	spectroscopy	NOUN
gs-3799	748	7	on	on	ADP
gs-3799	748	8	postoperative	postoperative	ADJ
gs-3799	748	9	delirium	delirium	NOUN
gs-3799	748	10	in	in	ADP
gs-3799	748	11	cardiac	cardiac	ADJ
gs-3799	748	12	surgery	surgery	NOUN
gs-3799	748	13	with	with	ADP
gs-3799	748	14	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	748	15	bypass	bypass	NOUN
gs-3799	748	16	:	:	PUNCT
gs-3799	748	17	a	a	DET
gs-3799	748	18	systematic	systematic	ADJ
gs-3799	748	19	review	review	NOUN
gs-3799	748	20	and	and	CCONJ
gs-3799	748	21	meta	meta	ADJ
gs-3799	748	22	-	-	PUNCT
gs-3799	748	23	analysis	analysis	NOUN
gs-3799	748	24	.	.	PUNCT
gs-3799	749	1	frontiers	frontier	NOUN
gs-3799	749	2	in	in	ADP
gs-3799	749	3	medicine	medicine	NOUN
gs-3799	749	4	,	,	PUNCT
gs-3799	749	5	12	12	NUM
gs-3799	749	6	,	,	PUNCT
gs-3799	749	7	11221214	11221214	NUM
gs-3799	749	8	.	.	PUNCT
gs-3799	750	1	9	9	NUM
gs-3799	750	2	.	.	X
gs-3799	750	3	slater	slater	PROPN
gs-3799	750	4	,	,	PUNCT
gs-3799	750	5	j.	j.	PROPN
gs-3799	750	6	p.	p.	PROPN
gs-3799	750	7	,	,	PUNCT
gs-3799	750	8	guarino	guarino	PROPN
gs-3799	750	9	,	,	PUNCT
gs-3799	750	10	t.	t.	NOUN
gs-3799	750	11	,	,	PUNCT
gs-3799	750	12	stack	stack	NOUN
gs-3799	750	13	,	,	PUNCT
gs-3799	750	14	j.	j.	PROPN
gs-3799	750	15	,	,	PUNCT
gs-3799	750	16	vinod	vinod	PROPN
gs-3799	750	17	,	,	PUNCT
gs-3799	750	18	k.	k.	PROPN
gs-3799	750	19	,	,	PUNCT
gs-3799	750	20	bustami	bustami	NOUN
gs-3799	750	21	,	,	PUNCT
gs-3799	750	22	r.	r.	PROPN
gs-3799	750	23	t.	t.	PROPN
gs-3799	750	24	,	,	PUNCT
gs-3799	750	25	brown	brown	PROPN
gs-3799	750	26	,	,	PUNCT
gs-3799	750	27	j.	j.	PROPN
gs-3799	750	28	m.	m.	PROPN
gs-3799	750	29	,	,	PUNCT
gs-3799	750	30	&	&	CCONJ
gs-3799	750	31	gottesman	gottesman	PROPN
gs-3799	750	32	,	,	PUNCT
gs-3799	750	33	r.	r.	PROPN
gs-3799	750	34	f.	f.	PROPN
gs-3799	750	35	(	(	PUNCT
gs-3799	750	36	2017	2017	NUM
gs-3799	750	37	)	)	PUNCT
gs-3799	750	38	.	.	PUNCT
gs-3799	751	1	perioperative	perioperative	ADJ
gs-3799	751	2	near	near	ADV
gs-3799	751	3	-	-	PUNCT
gs-3799	751	4	infrared	infrared	ADJ
gs-3799	751	5	spectroscopy	spectroscopy	NOUN
gs-3799	751	6	monitoring	monitoring	NOUN
gs-3799	751	7	in	in	ADP
gs-3799	751	8	neonates	neonate	NOUN
gs-3799	751	9	undergoing	undergo	VERB
gs-3799	751	10	cardiac	cardiac	ADJ
gs-3799	751	11	surgery	surgery	NOUN
gs-3799	751	12	:	:	PUNCT
gs-3799	751	13	association	association	NOUN
gs-3799	751	14	with	with	ADP
gs-3799	751	15	neurodevelopmental	neurodevelopmental	ADJ
gs-3799	751	16	outcomes	outcome	NOUN
gs-3799	751	17	.	.	PUNCT
gs-3799	752	1	pediatric	pediatric	ADJ
gs-3799	752	2	critical	critical	ADJ
gs-3799	752	3	care	care	NOUN
gs-3799	752	4	medicine	medicine	NOUN
gs-3799	752	5	,	,	PUNCT
gs-3799	752	6	18(3	18(3	NUM
gs-3799	752	7	)	)	PUNCT
gs-3799	752	8	,	,	PUNCT
gs-3799	752	9	213–220	213–220	NUM
gs-3799	752	10	.	.	NOUN
gs-3799	752	11	10	10	NUM
gs-3799	752	12	.	.	PUNCT
gs-3799	753	1	ranucci	ranucci	PROPN
gs-3799	753	2	,	,	PUNCT
gs-3799	753	3	m.	m.	NOUN
gs-3799	753	4	,	,	PUNCT
gs-3799	753	5	isgrò	isgrò	PROPN
gs-3799	753	6	,	,	PUNCT
gs-3799	753	7	g.	g.	PROPN
gs-3799	753	8	,	,	PUNCT
gs-3799	753	9	carlucci	carlucci	PROPN
gs-3799	753	10	,	,	PUNCT
gs-3799	753	11	c.	c.	PROPN
gs-3799	753	12	,	,	PUNCT
gs-3799	753	13	de	de	PROPN
gs-3799	753	14	benedetti	benedetti	PROPN
gs-3799	753	15	,	,	PUNCT
gs-3799	753	16	d.	d.	PROPN
gs-3799	753	17	,	,	PUNCT
gs-3799	753	18	&	&	CCONJ
gs-3799	753	19	conti	conti	PROPN
gs-3799	753	20	,	,	PUNCT
gs-3799	753	21	d.	d.	PROPN
gs-3799	753	22	(	(	PUNCT
gs-3799	753	23	2008	2008	NUM
gs-3799	753	24	)	)	PUNCT
gs-3799	753	25	.	.	PUNCT
gs-3799	754	1	continuous	continuous	ADJ
gs-3799	754	2	monitoring	monitoring	NOUN
gs-3799	754	3	of	of	ADP
gs-3799	754	4	central	central	ADJ
gs-3799	754	5	venous	venous	ADJ
gs-3799	754	6	oxygen	oxygen	NOUN
gs-3799	754	7	saturation	saturation	NOUN
gs-3799	754	8	(	(	PUNCT
gs-3799	754	9	pediasat	pediasat	ADJ
gs-3799	754	10	)	)	PUNCT
gs-3799	754	11	in	in	ADP
gs-3799	754	12	pediatric	pediatric	ADJ
gs-3799	754	13	patients	patient	NOUN
gs-3799	754	14	undergoing	undergo	VERB
gs-3799	754	15	cardiac	cardiac	ADJ
gs-3799	754	16	surgery	surgery	NOUN
gs-3799	754	17	:	:	PUNCT
gs-3799	754	18	a	a	DET
gs-3799	754	19	validation	validation	NOUN
gs-3799	754	20	study	study	NOUN
gs-3799	754	21	of	of	ADP
gs-3799	754	22	a	a	DET
gs-3799	754	23	new	new	ADJ
gs-3799	754	24	technology	technology	NOUN
gs-3799	754	25	.	.	PUNCT
gs-3799	755	1	journal	journal	NOUN
gs-3799	755	2	of	of	ADP
gs-3799	755	3	cardiothoracic	cardiothoracic	NOUN
gs-3799	755	4	and	and	CCONJ
gs-3799	755	5	vascular	vascular	VERB
gs-3799	755	6	anesthesia	anesthesia	NOUN
gs-3799	755	7	,	,	PUNCT
gs-3799	755	8	22(6	22(6	NUM
gs-3799	755	9	)	)	PUNCT
gs-3799	755	10	,	,	PUNCT
gs-3799	755	11	847–852	847–852	NUM
gs-3799	755	12	.	.	PUNCT
gs-3799	756	1	11	11	NUM
gs-3799	756	2	.	.	PUNCT
gs-3799	757	1	reinhart	reinhart	PROPN
gs-3799	757	2	,	,	PUNCT
gs-3799	757	3	k.	k.	PROPN
gs-3799	757	4	,	,	PUNCT
gs-3799	757	5	bloos	bloos	PROPN
gs-3799	757	6	,	,	PUNCT
gs-3799	757	7	f.	f.	PROPN
gs-3799	757	8	,	,	PUNCT
gs-3799	757	9	&	&	CCONJ
gs-3799	757	10	konig	konig	PROPN
gs-3799	757	11	,	,	PUNCT
gs-3799	757	12	f.	f.	PROPN
gs-3799	757	13	(	(	PUNCT
gs-3799	757	14	2004	2004	NUM
gs-3799	757	15	)	)	PUNCT
gs-3799	757	16	.	.	PUNCT
gs-3799	758	1	continuous	continuous	ADJ
gs-3799	758	2	central	central	ADJ
gs-3799	758	3	venous	venous	ADJ
gs-3799	758	4	and	and	CCONJ
gs-3799	758	5	pulmonary	pulmonary	ADJ
gs-3799	758	6	artery	artery	NOUN
gs-3799	758	7	oxygen	oxygen	NOUN
gs-3799	758	8	saturation	saturation	NOUN
gs-3799	758	9	monitoring	monitoring	NOUN
gs-3799	758	10	in	in	ADP
gs-3799	758	11	the	the	DET
gs-3799	758	12	critically	critically	ADV
gs-3799	758	13	ill	ill	ADJ
gs-3799	758	14	.	.	PUNCT
gs-3799	758	15	intensive	intensive	ADJ
gs-3799	758	16	care	care	NOUN
gs-3799	758	17	medicine	medicine	NOUN
gs-3799	758	18	,	,	PUNCT
gs-3799	758	19	30(8	30(8	NUM
gs-3799	758	20	)	)	PUNCT
gs-3799	758	21	,	,	PUNCT
gs-3799	758	22	1572–1578	1572–1578	NUM
gs-3799	758	23	.	.	PUNCT
gs-3799	759	1	georgian	georgian	NOUN
gs-3799	759	2	scientists/	scientists/	NUM
gs-3799	759	3	.	.	PUNCT
gs-3799	760	1	7	7	NUM
gs-3799	760	2	n	n	PRON
gs-3799	760	3	2	2	NUM
gs-3799	760	4	,	,	PUNCT
gs-3799	760	5	2025	2025	NUM
gs-3799	760	6	417	417	NUM
gs-3799	760	7	12	12	NUM
gs-3799	760	8	.	.	PUNCT
gs-3799	761	1	mahajan	mahajan	PROPN
gs-3799	761	2	,	,	PUNCT
gs-3799	761	3	a.	a.	PROPN
gs-3799	761	4	,	,	PUNCT
gs-3799	761	5	rath	rath	PROPN
gs-3799	761	6	,	,	PUNCT
gs-3799	761	7	g.	g.	PROPN
gs-3799	761	8	p.	p.	PROPN
gs-3799	761	9	,	,	PUNCT
gs-3799	761	10	&	&	CCONJ
gs-3799	761	11	bithal	bithal	PROPN
gs-3799	761	12	,	,	PUNCT
gs-3799	761	13	p.	p.	PROPN
gs-3799	761	14	k.	k.	PROPN
gs-3799	761	15	(	(	PUNCT
gs-3799	761	16	2007	2007	NUM
gs-3799	761	17	)	)	PUNCT
gs-3799	761	18	.	.	PUNCT
gs-3799	762	1	an	an	DET
gs-3799	762	2	experimental	experimental	ADJ
gs-3799	762	3	and	and	CCONJ
gs-3799	762	4	clinical	clinical	ADJ
gs-3799	762	5	evaluation	evaluation	NOUN
gs-3799	762	6	of	of	ADP
gs-3799	762	7	a	a	DET
gs-3799	762	8	novel	novel	ADJ
gs-3799	762	9	central	central	ADJ
gs-3799	762	10	venous	venous	ADJ
gs-3799	762	11	catheter	catheter	NOUN
gs-3799	762	12	with	with	ADP
gs-3799	762	13	integrated	integrated	ADJ
gs-3799	762	14	oximetry	oximetry	NOUN
gs-3799	762	15	for	for	ADP
gs-3799	762	16	pediatric	pediatric	ADJ
gs-3799	762	17	patients	patient	NOUN
gs-3799	762	18	undergoing	undergo	VERB
gs-3799	762	19	cardiac	cardiac	ADJ
gs-3799	762	20	surgery	surgery	NOUN
gs-3799	762	21	.	.	PUNCT
gs-3799	763	1	anesthesia	anesthesia	PROPN
gs-3799	763	2	&	&	CCONJ
gs-3799	763	3	analgesia	analgesia	PROPN
gs-3799	763	4	,	,	PUNCT
gs-3799	763	5	105(6	105(6	NUM
gs-3799	763	6	)	)	PUNCT
gs-3799	763	7	,	,	PUNCT
gs-3799	763	8	1598–1602	1598–1602	NUM
gs-3799	763	9	.	.	PUNCT
gs-3799	764	1	https://doi.org/10.1213/01.ane.0000287655.96414.3e	https://doi.org/10.1213/01.ane.0000287655.96414.3e	ADJ
gs-3799	764	2	13	13	NUM
gs-3799	764	3	.	.	PUNCT
gs-3799	765	1	rivers	river	NOUN
gs-3799	765	2	,	,	PUNCT
gs-3799	765	3	e.	e.	PROPN
gs-3799	765	4	p.	p.	PROPN
gs-3799	765	5	,	,	PUNCT
gs-3799	765	6	ander	ander	PROPN
gs-3799	765	7	,	,	PUNCT
gs-3799	765	8	d.	d.	PROPN
gs-3799	765	9	s.	s.	PROPN
gs-3799	765	10	,	,	PUNCT
gs-3799	765	11	powell	powell	PROPN
gs-3799	765	12	,	,	PUNCT
gs-3799	765	13	d.	d.	PROPN
gs-3799	765	14	,	,	PUNCT
gs-3799	765	15	&	&	CCONJ
gs-3799	765	16	martin	martin	PROPN
gs-3799	765	17	,	,	PUNCT
gs-3799	765	18	c.	c.	PROPN
gs-3799	765	19	m.	m.	NOUN
gs-3799	765	20	(	(	PUNCT
gs-3799	765	21	2001	2001	NUM
gs-3799	765	22	)	)	PUNCT
gs-3799	765	23	.	.	PUNCT
gs-3799	766	1	central	central	ADJ
gs-3799	766	2	venous	venous	ADJ
gs-3799	766	3	oxygen	oxygen	NOUN
gs-3799	766	4	saturation	saturation	NOUN
gs-3799	766	5	monitoring	monitoring	NOUN
gs-3799	766	6	in	in	ADP
gs-3799	766	7	the	the	DET
gs-3799	766	8	critically	critically	ADV
gs-3799	766	9	ill	ill	ADJ
gs-3799	766	10	patient	patient	NOUN
gs-3799	766	11	.	.	PUNCT
gs-3799	767	1	current	current	ADJ
gs-3799	767	2	opinion	opinion	NOUN
gs-3799	767	3	in	in	ADP
gs-3799	767	4	critical	critical	ADJ
gs-3799	767	5	care	care	NOUN
gs-3799	767	6	,	,	PUNCT
gs-3799	767	7	7(3	7(3	NUM
gs-3799	767	8	)	)	PUNCT
gs-3799	767	9	,	,	PUNCT
gs-3799	767	10	204–211	204–211	NUM
gs-3799	767	11	.	.	PUNCT
gs-3799	768	1	14	14	NUM
gs-3799	768	2	.	.	PUNCT
gs-3799	769	1	pearse	pearse	PROPN
gs-3799	769	2	,	,	PUNCT
gs-3799	769	3	r.	r.	PROPN
gs-3799	769	4	m.	m.	PROPN
gs-3799	769	5	,	,	PUNCT
gs-3799	769	6	dawson	dawson	PROPN
gs-3799	769	7	,	,	PUNCT
gs-3799	769	8	d.	d.	PROPN
gs-3799	769	9	,	,	PUNCT
gs-3799	769	10	fawcett	fawcett	PROPN
gs-3799	769	11	,	,	PUNCT
gs-3799	769	12	j.	j.	PROPN
gs-3799	769	13	,	,	PUNCT
gs-3799	769	14	rhodes	rhodes	PROPN
gs-3799	769	15	,	,	PUNCT
gs-3799	769	16	a.	a.	NOUN
gs-3799	769	17	,	,	PUNCT
gs-3799	769	18	grounds	ground	NOUN
gs-3799	769	19	,	,	PUNCT
gs-3799	769	20	r.	r.	PROPN
gs-3799	769	21	m.	m.	PROPN
gs-3799	769	22	,	,	PUNCT
gs-3799	769	23	&	&	CCONJ
gs-3799	769	24	bennett	bennett	PROPN
gs-3799	769	25	,	,	PUNCT
gs-3799	769	26	e.	e.	PROPN
gs-3799	769	27	d.	d.	PROPN
gs-3799	769	28	(	(	PUNCT
gs-3799	769	29	2005	2005	NUM
gs-3799	769	30	)	)	PUNCT
gs-3799	769	31	.	.	PUNCT
gs-3799	770	1	changes	change	NOUN
gs-3799	770	2	in	in	ADP
gs-3799	770	3	central	central	ADJ
gs-3799	770	4	venous	venous	ADJ
gs-3799	770	5	saturation	saturation	NOUN
gs-3799	770	6	after	after	ADP
gs-3799	770	7	major	major	ADJ
gs-3799	770	8	surgery	surgery	NOUN
gs-3799	770	9	,	,	PUNCT
gs-3799	770	10	and	and	CCONJ
gs-3799	770	11	association	association	NOUN
gs-3799	770	12	with	with	ADP
gs-3799	770	13	outcome	outcome	NOUN
gs-3799	770	14	.	.	PUNCT
gs-3799	771	1	critical	critical	ADJ
gs-3799	771	2	care	care	NOUN
gs-3799	771	3	,	,	PUNCT
gs-3799	771	4	9(6	9(6	NUM
gs-3799	771	5	)	)	PUNCT
gs-3799	771	6	,	,	PUNCT
gs-3799	771	7	r694	r694	PROPN
gs-3799	771	8	–	–	PUNCT
gs-3799	771	9	r699	r699	NUM
gs-3799	771	10	.	.	PROPN
gs-3799	771	11	15	15	NUM
gs-3799	771	12	.	.	PUNCT
gs-3799	772	1	scalea	scalea	ADJ
gs-3799	772	2	,	,	PUNCT
gs-3799	772	3	t.	t.	NOUN
gs-3799	772	4	m.	m.	NOUN
gs-3799	772	5	,	,	PUNCT
gs-3799	772	6	holman	holman	PROPN
gs-3799	772	7	,	,	PUNCT
gs-3799	772	8	m.	m.	NOUN
gs-3799	772	9	,	,	PUNCT
gs-3799	772	10	fuortes	fuorte	NOUN
gs-3799	772	11	,	,	PUNCT
gs-3799	772	12	m.	m.	NOUN
gs-3799	772	13	,	,	PUNCT
gs-3799	772	14	baron	baron	NOUN
gs-3799	772	15	,	,	PUNCT
gs-3799	772	16	b.	b.	PROPN
gs-3799	772	17	j.	j.	PROPN
gs-3799	772	18	,	,	PUNCT
gs-3799	772	19	phillips	phillips	PROPN
gs-3799	772	20	,	,	PUNCT
gs-3799	772	21	t.	t.	PROPN
gs-3799	772	22	f.	f.	PROPN
gs-3799	772	23	,	,	PUNCT
gs-3799	772	24	&	&	CCONJ
gs-3799	772	25	goldstein	goldstein	PROPN
gs-3799	772	26	,	,	PUNCT
gs-3799	772	27	a.	a.	PROPN
gs-3799	772	28	s.	s.	PROPN
gs-3799	772	29	(	(	PUNCT
gs-3799	772	30	2007	2007	NUM
gs-3799	772	31	)	)	PUNCT
gs-3799	772	32	.	.	PUNCT
gs-3799	773	1	central	central	ADJ
gs-3799	773	2	venous	venous	ADJ
gs-3799	773	3	oxygen	oxygen	NOUN
gs-3799	773	4	saturation	saturation	NOUN
gs-3799	773	5	:	:	PUNCT
gs-3799	773	6	a	a	DET
gs-3799	773	7	useful	useful	ADJ
gs-3799	773	8	clinical	clinical	ADJ
gs-3799	773	9	tool	tool	NOUN
gs-3799	773	10	in	in	ADP
gs-3799	773	11	trauma	trauma	NOUN
gs-3799	773	12	patients	patient	NOUN
gs-3799	773	13	.	.	PUNCT
gs-3799	774	1	pediatric	pediatric	ADJ
gs-3799	774	2	critical	critical	ADJ
gs-3799	774	3	care	care	NOUN
gs-3799	774	4	medicine	medicine	NOUN
gs-3799	774	5	,	,	PUNCT
gs-3799	774	6	8(3	8(3	NUM
gs-3799	774	7	suppl	suppl	NOUN
gs-3799	774	8	)	)	PUNCT
gs-3799	774	9	,	,	PUNCT
gs-3799	774	10	s50	s50	NOUN
gs-3799	774	11	–	–	PUNCT
gs-3799	774	12	s54	s54	NOUN
gs-3799	774	13	.	.	PUNCT
gs-3799	775	1	16	16	NUM
gs-3799	775	2	.	.	PUNCT
gs-3799	776	1	tweddell	tweddell	PROPN
gs-3799	776	2	,	,	PUNCT
gs-3799	776	3	j.	j.	PROPN
gs-3799	776	4	s.	s.	PROPN
gs-3799	776	5	,	,	PUNCT
gs-3799	776	6	hoffman	hoffman	PROPN
gs-3799	776	7	,	,	PUNCT
gs-3799	776	8	g.	g.	PROPN
gs-3799	776	9	m.	m.	PROPN
gs-3799	776	10	,	,	PUNCT
gs-3799	776	11	mussatto	mussatto	PROPN
gs-3799	776	12	,	,	PUNCT
gs-3799	776	13	k.	k.	PROPN
gs-3799	776	14	a.	a.	PROPN
gs-3799	776	15	,	,	PUNCT
gs-3799	776	16	fedderly	fedderly	ADV
gs-3799	776	17	,	,	PUNCT
gs-3799	776	18	r.	r.	PROPN
gs-3799	776	19	t.	t.	PROPN
gs-3799	776	20	,	,	PUNCT
gs-3799	776	21	berger	berger	PROPN
gs-3799	776	22	,	,	PUNCT
gs-3799	776	23	s.	s.	PROPN
gs-3799	776	24	,	,	PUNCT
gs-3799	776	25	jaquiss	jaquiss	PROPN
gs-3799	776	26	,	,	PUNCT
gs-3799	776	27	r.	r.	PROPN
gs-3799	776	28	d.	d.	PROPN
gs-3799	776	29	b.	b.	PROPN
gs-3799	776	30	,	,	PUNCT
gs-3799	776	31	&	&	CCONJ
gs-3799	776	32	ghanayem	ghanayem	PROPN
gs-3799	776	33	,	,	PUNCT
gs-3799	776	34	n.	n.	PROPN
gs-3799	776	35	s.	s.	PROPN
gs-3799	776	36	(	(	PUNCT
gs-3799	776	37	2002	2002	NUM
gs-3799	776	38	)	)	PUNCT
gs-3799	776	39	.	.	PUNCT
gs-3799	777	1	postoperative	postoperative	ADJ
gs-3799	777	2	management	management	NOUN
gs-3799	777	3	in	in	ADP
gs-3799	777	4	patients	patient	NOUN
gs-3799	777	5	with	with	ADP
gs-3799	777	6	complex	complex	ADJ
gs-3799	777	7	congenital	congenital	ADJ
gs-3799	777	8	heart	heart	NOUN
gs-3799	777	9	disease	disease	NOUN
gs-3799	777	10	.	.	PUNCT
gs-3799	778	1	seminars	seminar	NOUN
gs-3799	778	2	in	in	ADP
gs-3799	778	3	thoracic	thoracic	NOUN
gs-3799	778	4	and	and	CCONJ
gs-3799	778	5	cardiovascular	cardiovascular	ADJ
gs-3799	778	6	surgery	surgery	NOUN
gs-3799	778	7	:	:	PUNCT
gs-3799	778	8	pediatric	pediatric	ADJ
gs-3799	778	9	cardiac	cardiac	ADJ
gs-3799	778	10	surgery	surgery	NOUN
gs-3799	778	11	annual	annual	ADJ
gs-3799	778	12	,	,	PUNCT
gs-3799	778	13	5	5	NUM
gs-3799	778	14	,	,	PUNCT
gs-3799	778	15	187–205	187–205	NUM
gs-3799	778	16	.	.	PUNCT
gs-3799	778	17	17	17	NUM
gs-3799	778	18	.	.	PUNCT
gs-3799	779	1	sanders	sanders	PROPN
gs-3799	779	2	,	,	PUNCT
gs-3799	779	3	c.	c.	PROPN
gs-3799	779	4	l.	l.	PROPN
gs-3799	779	5	(	(	PUNCT
gs-3799	779	6	1997	1997	NUM
gs-3799	779	7	)	)	PUNCT
gs-3799	779	8	.	.	PUNCT
gs-3799	780	1	making	make	VERB
gs-3799	780	2	clinical	clinical	ADJ
gs-3799	780	3	decisions	decision	NOUN
gs-3799	780	4	using	use	VERB
gs-3799	780	5	svo2	svo2	PROPN
gs-3799	780	6	in	in	ADP
gs-3799	780	7	picu	picu	PROPN
gs-3799	780	8	patients	patient	NOUN
gs-3799	780	9	.	.	PUNCT
gs-3799	781	1	dimensions	dimension	NOUN
gs-3799	781	2	of	of	ADP
gs-3799	781	3	critical	critical	ADJ
gs-3799	781	4	care	care	NOUN
gs-3799	781	5	nursing	nursing	NOUN
gs-3799	781	6	,	,	PUNCT
gs-3799	781	7	16(5	16(5	NUM
gs-3799	781	8	)	)	PUNCT
gs-3799	781	9	,	,	PUNCT
gs-3799	781	10	257–264	257–264	NUM
gs-3799	781	11	.	.	PUNCT
gs-3799	782	1	18	18	NUM
gs-3799	782	2	.	.	PUNCT
gs-3799	782	3	mohseni	mohseni	PROPN
gs-3799	782	4	,	,	PUNCT
gs-3799	782	5	h.	h.	PROPN
gs-3799	782	6	,	,	PUNCT
gs-3799	782	7	&	&	CCONJ
gs-3799	782	8	wang	wang	PROPN
gs-3799	782	9	,	,	PUNCT
gs-3799	782	10	y.	y.	PROPN
gs-3799	782	11	(	(	PUNCT
gs-3799	782	12	2011	2011	NUM
gs-3799	782	13	)	)	PUNCT
gs-3799	782	14	.	.	PUNCT
gs-3799	783	1	evaluation	evaluation	NOUN
gs-3799	783	2	of	of	ADP
gs-3799	783	3	a	a	DET
gs-3799	783	4	new	new	ADJ
gs-3799	783	5	pediatric	pediatric	ADJ
gs-3799	783	6	continuous	continuous	ADJ
gs-3799	783	7	oximetry	oximetry	NOUN
gs-3799	783	8	catheter	catheter	NOUN
gs-3799	783	9	.	.	PUNCT
gs-3799	784	1	pediatric	pediatric	ADJ
gs-3799	784	2	critical	critical	ADJ
gs-3799	784	3	care	care	NOUN
gs-3799	784	4	medicine	medicine	NOUN
gs-3799	784	5	,	,	PUNCT
gs-3799	784	6	12(4	12(4	NUM
gs-3799	784	7	)	)	PUNCT
gs-3799	784	8	,	,	PUNCT
gs-3799	784	9	437–441	437–441	NUM
gs-3799	784	10	.	.	PUNCT
gs-3799	785	1	19	19	NUM
gs-3799	785	2	.	.	X
gs-3799	785	3	lemson	lemson	PROPN
gs-3799	785	4	,	,	PUNCT
gs-3799	785	5	j.	j.	PROPN
gs-3799	785	6	,	,	PUNCT
gs-3799	785	7	&	&	CCONJ
gs-3799	785	8	van	van	PROPN
gs-3799	785	9	der	der	PROPN
gs-3799	785	10	hoeven	hoeven	PROPN
gs-3799	785	11	,	,	PUNCT
gs-3799	785	12	j.	j.	PROPN
gs-3799	785	13	g.	g.	PROPN
gs-3799	785	14	(	(	PUNCT
gs-3799	785	15	2011	2011	NUM
gs-3799	785	16	)	)	PUNCT
gs-3799	785	17	.	.	PUNCT
gs-3799	786	1	advanced	advanced	ADJ
gs-3799	786	2	hemodynamic	hemodynamic	ADJ
gs-3799	786	3	monitoring	monitoring	NOUN
gs-3799	786	4	in	in	ADP
gs-3799	786	5	critically	critically	ADV
gs-3799	786	6	ill	ill	ADJ
gs-3799	786	7	patients	patient	NOUN
gs-3799	786	8	.	.	PUNCT
gs-3799	787	1	pediatrics	pediatric	NOUN
gs-3799	787	2	,	,	PUNCT
gs-3799	787	3	127(5	127(5	NUM
gs-3799	787	4	)	)	PUNCT
gs-3799	787	5	,	,	PUNCT
gs-3799	787	6	e1177	e1177	PROPN
gs-3799	787	7	–	–	PUNCT
gs-3799	787	8	e1183	e1183	NOUN
gs-3799	787	9	.	.	NOUN
gs-3799	787	10	20	20	NUM
gs-3799	787	11	.	.	PUNCT
gs-3799	788	1	ranucci	ranucci	PROPN
gs-3799	788	2	,	,	PUNCT
gs-3799	788	3	m.	m.	NOUN
gs-3799	788	4	,	,	PUNCT
gs-3799	788	5	isgrò	isgrò	PROPN
gs-3799	788	6	,	,	PUNCT
gs-3799	788	7	g.	g.	PROPN
gs-3799	788	8	,	,	PUNCT
gs-3799	788	9	carlucci	carlucci	PROPN
gs-3799	788	10	,	,	PUNCT
gs-3799	788	11	c.	c.	PROPN
gs-3799	788	12	,	,	PUNCT
gs-3799	788	13	de	de	PROPN
gs-3799	788	14	benedetti	benedetti	PROPN
gs-3799	788	15	,	,	PUNCT
gs-3799	788	16	d.	d.	PROPN
gs-3799	788	17	,	,	PUNCT
gs-3799	788	18	&	&	CCONJ
gs-3799	788	19	conti	conti	PROPN
gs-3799	788	20	,	,	PUNCT
gs-3799	788	21	d.	d.	PROPN
gs-3799	788	22	(	(	PUNCT
gs-3799	788	23	2008	2008	NUM
gs-3799	788	24	)	)	PUNCT
gs-3799	788	25	.	.	PUNCT
gs-3799	789	1	near	near	ADV
gs-3799	789	2	-	-	PUNCT
gs-3799	789	3	infrared	infrared	ADJ
gs-3799	789	4	spectroscopy	spectroscopy	NOUN
gs-3799	789	5	correlates	correlate	VERB
gs-3799	789	6	with	with	ADP
gs-3799	789	7	continuous	continuous	ADJ
gs-3799	789	8	superior	superior	ADJ
gs-3799	789	9	vena	vena	NOUN
gs-3799	789	10	cava	cava	NOUN
gs-3799	789	11	oxygen	oxygen	NOUN
gs-3799	789	12	saturation	saturation	NOUN
gs-3799	789	13	in	in	ADP
gs-3799	789	14	pediatric	pediatric	ADJ
gs-3799	789	15	cardiac	cardiac	ADJ
gs-3799	789	16	surgery	surgery	NOUN
gs-3799	789	17	patients	patient	NOUN
gs-3799	789	18	.	.	PUNCT
gs-3799	790	1	pediatric	pediatric	ADJ
gs-3799	790	2	anesthesia	anesthesia	PROPN
gs-3799	790	3	,	,	PUNCT
gs-3799	790	4	18(12	18(12	NUM
gs-3799	790	5	)	)	PUNCT
gs-3799	790	6	,	,	PUNCT
gs-3799	790	7	1163–1169	1163–1169	NUM
gs-3799	790	8	.	.	NOUN
gs-3799	790	9	21	21	NUM
gs-3799	790	10	.	.	PUNCT
gs-3799	791	1	adams	adams	PROPN
gs-3799	791	2	,	,	PUNCT
gs-3799	791	3	benjamin	benjamin	PROPN
gs-3799	791	4	d.	d.	PROPN
gs-3799	791	5	,	,	PUNCT
gs-3799	791	6	hiroshi	hiroshi	PROPN
gs-3799	791	7	tanaka	tanaka	PROPN
gs-3799	791	8	,	,	PUNCT
gs-3799	791	9	and	and	CCONJ
gs-3799	791	10	sarah	sarah	PROPN
gs-3799	791	11	j.	j.	PROPN
gs-3799	791	12	williams	williams	PROPN
gs-3799	791	13	.	.	PROPN
gs-3799	791	14	2022	2022	NUM
gs-3799	791	15	.	.	PUNCT
gs-3799	792	1	"	"	PUNCT
gs-3799	792	2	closed	closed	ADJ
gs-3799	792	3	-	-	PUNCT
gs-3799	792	4	loop	loop	NOUN
gs-3799	792	5	control	control	NOUN
gs-3799	792	6	of	of	ADP
gs-3799	792	7	heparin	heparin	NOUN
gs-3799	792	8	dosing	dose	VERB
gs-3799	792	9	during	during	ADP
gs-3799	792	10	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	792	11	bypass	bypass	NOUN
gs-3799	792	12	:	:	PUNCT
gs-3799	792	13	a	a	DET
gs-3799	792	14	randomized	randomized	ADJ
gs-3799	792	15	clinical	clinical	ADJ
gs-3799	792	16	trial	trial	NOUN
gs-3799	792	17	.	.	PUNCT
gs-3799	792	18	"	"	PUNCT
gs-3799	793	1	journal	journal	NOUN
gs-3799	793	2	of	of	ADP
gs-3799	793	3	thoracic	thoracic	NOUN
gs-3799	793	4	and	and	CCONJ
gs-3799	793	5	cardiovascular	cardiovascular	ADJ
gs-3799	793	6	surgery	surgery	NOUN
gs-3799	793	7	164	164	NUM
gs-3799	793	8	,	,	PUNCT
gs-3799	793	9	no	no	INTJ
gs-3799	793	10	.	.	NOUN
gs-3799	793	11	5	5	NUM
gs-3799	793	12	(	(	PUNCT
gs-3799	793	13	november	november	PROPN
gs-3799	793	14	):	):	PUNCT
gs-3799	793	15	1421–1432	1421–1432	NUM
gs-3799	793	16	.	.	PUNCT
gs-3799	794	1	22	22	NUM
gs-3799	794	2	.	.	PUNCT
gs-3799	795	1	anthea	anthea	PROPN
gs-3799	795	2	hospital	hospital	PROPN
gs-3799	795	3	,	,	PUNCT
gs-3799	795	4	gvm	gvm	PROPN
gs-3799	795	5	care	care	PROPN
gs-3799	795	6	&	&	CCONJ
gs-3799	795	7	research	research	PROPN
gs-3799	795	8	.	.	PUNCT
gs-3799	796	1	2024	2024	NUM
gs-3799	796	2	.	.	PUNCT
gs-3799	796	3	health	health	NOUN
gs-3799	796	4	technology	technology	NOUN
gs-3799	796	5	assessment	assessment	NOUN
gs-3799	796	6	of	of	ADP
gs-3799	796	7	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	796	8	bypass	bypass	NOUN
gs-3799	796	9	circuit	circuit	NOUN
gs-3799	796	10	with	with	ADP
gs-3799	796	11	and	and	CCONJ
gs-3799	796	12	without	without	ADP
gs-3799	796	13	phosphorylcholine	phosphorylcholine	ADJ
gs-3799	796	14	coating	coating	NOUN
gs-3799	796	15	:	:	PUNCT
gs-3799	796	16	a	a	DET
gs-3799	796	17	retrospective	retrospective	ADJ
gs-3799	796	18	study	study	NOUN
gs-3799	796	19	on	on	ADP
gs-3799	796	20	safety	safety	NOUN
gs-3799	796	21	and	and	CCONJ
gs-3799	796	22	efficiency	efficiency	NOUN
gs-3799	796	23	in	in	ADP
gs-3799	796	24	cardiac	cardiac	ADJ
gs-3799	796	25	surgery	surgery	NOUN
gs-3799	796	26	.	.	PUNCT
gs-3799	797	1	life	life	NOUN
gs-3799	797	2	(	(	PUNCT
gs-3799	797	3	basel	basel	PROPN
gs-3799	797	4	)	)	PUNCT
gs-3799	797	5	14	14	NUM
gs-3799	797	6	,	,	PUNCT
gs-3799	797	7	no	no	INTJ
gs-3799	797	8	.	.	NOUN
gs-3799	797	9	7	7	NUM
gs-3799	797	10	(	(	PUNCT
gs-3799	797	11	july	july	PROPN
gs-3799	797	12	):	):	PUNCT
gs-3799	797	13	851	851	NUM
gs-3799	797	14	.	.	PUNCT
gs-3799	797	15	23	23	NUM
gs-3799	797	16	.	.	PUNCT
gs-3799	798	1	burnett	burnett	PROPN
gs-3799	798	2	,	,	PUNCT
gs-3799	798	3	allison	allison	PROPN
gs-3799	798	4	,	,	PUNCT
gs-3799	798	5	and	and	CCONJ
gs-3799	798	6	kathryn	kathryn	PROPN
gs-3799	798	7	dane	dane	PROPN
gs-3799	798	8	.	.	PUNCT
gs-3799	798	9	2025	2025	NUM
gs-3799	798	10	.	.	PUNCT
gs-3799	799	1	"	"	PUNCT
gs-3799	799	2	venous	venous	ADJ
gs-3799	799	3	thromboembolism	thromboembolism	NOUN
gs-3799	799	4	:	:	PUNCT
gs-3799	799	5	primary	primary	ADJ
gs-3799	799	6	prevention	prevention	NOUN
gs-3799	799	7	.	.	PUNCT
gs-3799	799	8	"	"	PUNCT
gs-3799	800	1	in	in	ADP
gs-3799	800	2	*	*	PROPN
gs-3799	800	3	psap	psap	PROPN
gs-3799	800	4	2025	2025	NUM
gs-3799	800	5	book	book	NOUN
gs-3799	800	6	1	1	NUM
gs-3799	800	7	(	(	PUNCT
gs-3799	800	8	cardiology	cardiology	NOUN
gs-3799	800	9	):	):	PUNCT
gs-3799	800	10	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	800	11	self	self	NOUN
gs-3799	800	12	-	-	PUNCT
gs-3799	800	13	assessment	assessment	NOUN
gs-3799	800	14	program	program	NOUN
gs-3799	800	15	*	*	PUNCT
gs-3799	800	16	,	,	PUNCT
gs-3799	800	17	edited	edit	VERB
gs-3799	800	18	by	by	ADP
gs-3799	800	19	nicholas	nicholas	PROPN
gs-3799	800	20	w.	w.	PROPN
gs-3799	800	21	carris	carris	PROPN
gs-3799	800	22	,	,	PUNCT
gs-3799	800	23	145–168	145–168	NUM
gs-3799	800	24	.	.	PUNCT
gs-3799	800	25	accp	accp	PROPN
gs-3799	800	26	.	.	PUNCT
gs-3799	801	1	24	24	NUM
gs-3799	801	2	.	.	PUNCT
gs-3799	802	1	chen	chen	PROPN
gs-3799	802	2	,	,	PUNCT
gs-3799	802	3	wei	wei	PROPN
gs-3799	802	4	,	,	PUNCT
gs-3799	802	5	and	and	CCONJ
gs-3799	802	6	mehmet	mehmet	PROPN
gs-3799	802	7	ozturk	ozturk	PROPN
gs-3799	802	8	.	.	PUNCT
gs-3799	802	9	2023	2023	NUM
gs-3799	802	10	.	.	PUNCT
gs-3799	803	1	"	"	PUNCT
gs-3799	803	2	machine	machine	NOUN
gs-3799	803	3	learning	learn	VERB
gs-3799	803	4	algorithms	algorithm	NOUN
gs-3799	803	5	for	for	ADP
gs-3799	803	6	real	real	ADJ
gs-3799	803	7	-	-	PUNCT
gs-3799	803	8	time	time	NOUN
gs-3799	803	9	hemodynamic	hemodynamic	ADJ
gs-3799	803	10	stability	stability	NOUN
gs-3799	803	11	prediction	prediction	NOUN
gs-3799	803	12	in	in	ADP
gs-3799	803	13	automated	automate	VERB
gs-3799	803	14	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	803	15	bypass	bypass	NOUN
gs-3799	803	16	systems	system	NOUN
gs-3799	803	17	.	.	PUNCT
gs-3799	803	18	"	"	PUNCT
gs-3799	803	19	annals	annal	NOUN
gs-3799	803	20	of	of	ADP
gs-3799	803	21	biomedical	biomedical	ADJ
gs-3799	803	22	engineering	engineering	NOUN
gs-3799	803	23	51	51	NUM
gs-3799	803	24	,	,	PUNCT
gs-3799	803	25	no	no	INTJ
gs-3799	803	26	.	.	NOUN
gs-3799	804	1	4	4	NUM
gs-3799	804	2	:	:	PUNCT
gs-3799	805	1	799–812	799–812	NUM
gs-3799	805	2	.	.	NOUN
gs-3799	806	1	25	25	NUM
gs-3799	806	2	.	.	PUNCT
gs-3799	807	1	future	future	ADJ
gs-3799	807	2	market	market	NOUN
gs-3799	807	3	insights	insight	NOUN
gs-3799	807	4	.	.	PUNCT
gs-3799	808	1	2025	2025	NUM
gs-3799	808	2	.	.	PUNCT
gs-3799	809	1	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	809	2	bypass	bypass	NOUN
gs-3799	809	3	system	system	NOUN
gs-3799	809	4	market	market	NOUN
gs-3799	809	5	outlook	outlook	NOUN
gs-3799	809	6	2025	2025	NUM
gs-3799	809	7	to	to	ADP
gs-3799	809	8	2035	2035	NUM
gs-3799	809	9	.	.	PUNCT
gs-3799	810	1	26	26	NUM
gs-3799	810	2	.	.	PUNCT
gs-3799	810	3	kowaleski	kowaleski	PROPN
gs-3799	810	4	,	,	PUNCT
gs-3799	810	5	john	john	PROPN
gs-3799	810	6	,	,	PUNCT
gs-3799	810	7	et	et	PROPN
gs-3799	810	8	al	al	PROPN
gs-3799	810	9	.	.	PROPN
gs-3799	810	10	2025	2025	NUM
gs-3799	810	11	.	.	PUNCT
gs-3799	811	1	"	"	PUNCT
gs-3799	811	2	meta	meta	VERB
gs-3799	811	3	-	-	PUNCT
gs-3799	811	4	analysis	analysis	NOUN
gs-3799	811	5	of	of	ADP
gs-3799	811	6	miniaturized	miniaturize	VERB
gs-3799	811	7	extracorporeal	extracorporeal	NOUN
gs-3799	811	8	circuits	circuit	NOUN
gs-3799	811	9	in	in	ADP
gs-3799	811	10	coronary	coronary	ADJ
gs-3799	811	11	artery	artery	NOUN
gs-3799	811	12	bypass	bypass	NOUN
gs-3799	811	13	grafting	grafting	NOUN
gs-3799	811	14	:	:	PUNCT
gs-3799	811	15	clinical	clinical	ADJ
gs-3799	811	16	and	and	CCONJ
gs-3799	811	17	economic	economic	ADJ
gs-3799	811	18	outcomes	outcome	NOUN
gs-3799	811	19	.	.	PUNCT
gs-3799	811	20	"	"	PUNCT
gs-3799	812	1	the	the	DET
gs-3799	812	2	cardiothoracic	cardiothoracic	NOUN
gs-3799	812	3	surgeon	surgeon	NOUN
gs-3799	812	4	33	33	NUM
gs-3799	812	5	:	:	SYM
gs-3799	812	6	11	11	NUM
gs-3799	812	7	.	.	PUNCT
gs-3799	813	1	georgian	georgian	NOUN
gs-3799	813	2	scientists/	scientists/	NUM
gs-3799	813	3	.	.	PUNCT
gs-3799	814	1	7	7	NUM
gs-3799	814	2	n	n	PRON
gs-3799	814	3	2	2	NUM
gs-3799	814	4	,	,	PUNCT
gs-3799	814	5	2025	2025	NUM
gs-3799	814	6	418	418	NUM
gs-3799	814	7	27	27	NUM
gs-3799	814	8	.	.	PUNCT
gs-3799	815	1	miranda	miranda	NOUN
gs-3799	815	2	,	,	PUNCT
gs-3799	815	3	aimon	aimon	PROPN
gs-3799	815	4	c.	c.	PROPN
gs-3799	815	5	,	,	PUNCT
gs-3799	815	6	and	and	CCONJ
gs-3799	815	7	cyrille	cyrille	PROPN
gs-3799	815	8	cornelio	cornelio	PROPN
gs-3799	815	9	.	.	PUNCT
gs-3799	815	10	2025	2025	NUM
gs-3799	815	11	.	.	PUNCT
gs-3799	816	1	"	"	PUNCT
gs-3799	816	2	heart	heart	NOUN
gs-3799	816	3	failure	failure	NOUN
gs-3799	816	4	with	with	ADP
gs-3799	816	5	preserved	preserve	VERB
gs-3799	816	6	ejection	ejection	NOUN
gs-3799	816	7	fraction	fraction	NOUN
gs-3799	816	8	:	:	PUNCT
gs-3799	816	9	perioperative	perioperative	ADJ
gs-3799	816	10	management	management	NOUN
gs-3799	816	11	in	in	ADP
gs-3799	816	12	cardiac	cardiac	ADJ
gs-3799	816	13	surgery	surgery	NOUN
gs-3799	816	14	.	.	PUNCT
gs-3799	816	15	"	"	PUNCT
gs-3799	817	1	in	in	ADP
gs-3799	817	2	*	*	PROPN
gs-3799	817	3	psap	psap	PROPN
gs-3799	817	4	2025	2025	NUM
gs-3799	817	5	book	book	NOUN
gs-3799	817	6	1	1	NUM
gs-3799	817	7	(	(	PUNCT
gs-3799	817	8	cardiology	cardiology	NOUN
gs-3799	817	9	):	):	PUNCT
gs-3799	817	10	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	817	11	self	self	NOUN
gs-3799	817	12	-	-	PUNCT
gs-3799	817	13	assessment	assessment	NOUN
gs-3799	817	14	program	program	NOUN
gs-3799	817	15	*	*	PUNCT
gs-3799	817	16	,	,	PUNCT
gs-3799	817	17	edited	edit	VERB
gs-3799	817	18	by	by	ADP
gs-3799	817	19	nicholas	nicholas	PROPN
gs-3799	817	20	w.	w.	PROPN
gs-3799	817	21	carris	carris	PROPN
gs-3799	817	22	,	,	PUNCT
gs-3799	817	23	95–120	95–120	NUM
gs-3799	817	24	.	.	NOUN
gs-3799	817	25	28	28	NUM
gs-3799	817	26	.	.	PUNCT
gs-3799	817	27	national	national	PROPN
gs-3799	817	28	institutes	institutes	PROPN
gs-3799	817	29	of	of	ADP
gs-3799	817	30	health	health	NOUN
gs-3799	817	31	.	.	PUNCT
gs-3799	818	1	2024	2024	NUM
gs-3799	818	2	.	.	PUNCT
gs-3799	819	1	smart	smart	ADJ
gs-3799	819	2	perfusion	perfusion	NOUN
gs-3799	819	3	systems	system	NOUN
gs-3799	819	4	:	:	PUNCT
gs-3799	819	5	strategic	strategic	ADJ
gs-3799	819	6	roadmap	roadmap	NOUN
gs-3799	819	7	2025–2035	2025–2035	NUM
gs-3799	819	8	.	.	PUNCT
gs-3799	820	1	bethesda	bethesda	PROPN
gs-3799	820	2	,	,	PUNCT
gs-3799	820	3	md	md	PROPN
gs-3799	820	4	:	:	PUNCT
gs-3799	820	5	national	national	ADJ
gs-3799	820	6	heart	heart	NOUN
gs-3799	820	7	,	,	PUNCT
gs-3799	820	8	lung	lung	NOUN
gs-3799	820	9	,	,	PUNCT
gs-3799	820	10	and	and	CCONJ
gs-3799	820	11	blood	blood	NOUN
gs-3799	820	12	institute	institute	NOUN
gs-3799	820	13	.	.	PUNCT
gs-3799	821	1	29	29	NUM
gs-3799	821	2	.	.	PUNCT
gs-3799	822	1	rudd	rudd	PROPN
gs-3799	822	2	,	,	PUNCT
gs-3799	822	3	kelly	kelly	PROPN
gs-3799	822	4	m.	m.	PROPN
gs-3799	822	5	2025	2025	NUM
gs-3799	822	6	.	.	PUNCT
gs-3799	823	1	"	"	PUNCT
gs-3799	823	2	antithrombotic	antithrombotic	ADJ
gs-3799	823	3	therapy	therapy	NOUN
gs-3799	823	4	for	for	ADP
gs-3799	823	5	valvular	valvular	ADJ
gs-3799	823	6	heart	heart	NOUN
gs-3799	823	7	disease	disease	NOUN
gs-3799	823	8	.	.	PUNCT
gs-3799	823	9	"	"	PUNCT
gs-3799	824	1	in	in	ADP
gs-3799	824	2	*	*	PROPN
gs-3799	824	3	psap	psap	PROPN
gs-3799	824	4	2025	2025	NUM
gs-3799	824	5	book	book	NOUN
gs-3799	824	6	1	1	NUM
gs-3799	824	7	(	(	PUNCT
gs-3799	824	8	cardiology	cardiology	NOUN
gs-3799	824	9	):	):	PUNCT
gs-3799	824	10	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	824	11	self	self	NOUN
gs-3799	824	12	-	-	PUNCT
gs-3799	824	13	assessment	assessment	NOUN
gs-3799	824	14	program	program	NOUN
gs-3799	824	15	*	*	PUNCT
gs-3799	824	16	,	,	PUNCT
gs-3799	824	17	edited	edit	VERB
gs-3799	824	18	by	by	ADP
gs-3799	824	19	nicholas	nicholas	PROPN
gs-3799	824	20	w.	w.	PROPN
gs-3799	824	21	carris	carris	PROPN
gs-3799	824	22	,	,	PUNCT
gs-3799	824	23	185	185	NUM
gs-3799	824	24	–	–	PUNCT
gs-3799	824	25	200	200	NUM
gs-3799	824	26	.	.	NOUN
gs-3799	824	27	30	30	NUM
gs-3799	824	28	.	.	PUNCT
gs-3799	824	29	statpearls	statpearl	NOUN
gs-3799	824	30	publishing	publishing	NOUN
gs-3799	824	31	.	.	PUNCT
gs-3799	825	1	2025	2025	NUM
gs-3799	825	2	.	.	PUNCT
gs-3799	826	1	"	"	PUNCT
gs-3799	826	2	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	826	3	bypass	bypass	NOUN
gs-3799	826	4	.	.	PUNCT
gs-3799	826	5	"	"	PUNCT
gs-3799	827	1	in	in	ADP
gs-3799	827	2	statpearls	statpearl	NOUN
gs-3799	828	1	[	[	X
gs-3799	828	2	internet	internet	NOUN
gs-3799	828	3	]	]	PUNCT
gs-3799	828	4	.	.	PUNCT
gs-3799	829	1	treasure	treasure	NOUN
gs-3799	829	2	island	island	NOUN
gs-3799	829	3	,	,	PUNCT
gs-3799	829	4	fl	fl	PROPN
gs-3799	829	5	:	:	PUNCT
gs-3799	829	6	statpearls	statpearls	PROPN
gs-3799	829	7	publishing	publishing	NOUN
gs-3799	829	8	.	.	PUNCT
gs-3799	830	1	31	31	NUM
gs-3799	830	2	.	.	X
gs-3799	831	1	aphkhazava	aphkhazava	PROPN
gs-3799	831	2	,	,	PUNCT
gs-3799	831	3	david	david	PROPN
gs-3799	831	4	,	,	PUNCT
gs-3799	831	5	nodar	nodar	NOUN
gs-3799	831	6	sulashvili	sulashvili	NOUN
gs-3799	831	7	,	,	PUNCT
gs-3799	831	8	and	and	CCONJ
gs-3799	831	9	jaba	jaba	PROPN
gs-3799	831	10	tkemaladze	tkemaladze	PROPN
gs-3799	831	11	.	.	PUNCT
gs-3799	832	1	2025	2025	NUM
gs-3799	832	2	.	.	PUNCT
gs-3799	833	1	“	"	PUNCT
gs-3799	833	2	stem	stem	NOUN
gs-3799	833	3	cell	cell	NOUN
gs-3799	833	4	systems	system	NOUN
gs-3799	833	5	and	and	CCONJ
gs-3799	833	6	regeneration	regeneration	NOUN
gs-3799	833	7	”	"	PUNCT
gs-3799	833	8	.	.	PUNCT
gs-3799	834	1	georgian	georgian	PROPN
gs-3799	834	2	scientists	scientist	NOUN
gs-3799	834	3	7	7	NUM
gs-3799	834	4	(	(	PUNCT
gs-3799	834	5	1):271	1):271	NUM
gs-3799	834	6	-	-	SYM
gs-3799	834	7	319	319	NUM
gs-3799	834	8	.	.	PUNCT
gs-3799	835	1	https://doi.org/10.52340/gs.2025.07.01.26	https://doi.org/10.52340/gs.2025.07.01.26	NOUN
gs-3799	835	2	.	.	NOUN
gs-3799	836	1	32	32	NUM
gs-3799	836	2	.	.	X
gs-3799	837	1	aphkhazava	aphkhazava	PROPN
gs-3799	837	2	,	,	PUNCT
gs-3799	837	3	d.	d.	PROPN
gs-3799	837	4	,	,	PUNCT
gs-3799	837	5	sulashvili	sulashvili	NOUN
gs-3799	837	6	,	,	PUNCT
gs-3799	837	7	n.	n.	NOUN
gs-3799	837	8	,	,	PUNCT
gs-3799	837	9	tupinashvili	tupinashvili	NOUN
gs-3799	837	10	,	,	PUNCT
gs-3799	837	11	t.	t.	PROPN
gs-3799	837	12	,	,	PUNCT
gs-3799	837	13	&	&	CCONJ
gs-3799	837	14	nozadze	nozadze	NOUN
gs-3799	837	15	,	,	PUNCT
gs-3799	837	16	m.	m.	NOUN
gs-3799	837	17	(	(	PUNCT
gs-3799	837	18	2024	2024	NUM
gs-3799	837	19	)	)	PUNCT
gs-3799	837	20	.	.	PUNCT
gs-3799	838	1	dynamic	dynamic	ADJ
gs-3799	838	2	cellular	cellular	ADJ
gs-3799	838	3	equilibrium	equilibrium	NOUN
gs-3799	838	4	theory	theory	NOUN
gs-3799	838	5	of	of	ADP
gs-3799	838	6	aging	aging	NOUN
gs-3799	838	7	:	:	PUNCT
gs-3799	838	8	integrating	integrate	VERB
gs-3799	838	9	maintenance	maintenance	NOUN
gs-3799	838	10	and	and	CCONJ
gs-3799	838	11	accumulation	accumulation	NOUN
gs-3799	838	12	in	in	ADP
gs-3799	838	13	the	the	DET
gs-3799	838	14	aging	age	VERB
gs-3799	838	15	process	process	NOUN
gs-3799	838	16	.	.	PUNCT
gs-3799	839	1	scientific	scientific	ADJ
gs-3799	839	2	journal	journal	NOUN
gs-3799	839	3	„	„	PUNCT
gs-3799	839	4	spectri	spectri	NOUN
gs-3799	839	5	“	"	PUNCT
gs-3799	839	6	,	,	PUNCT
gs-3799	839	7	8(2	8(2	NUM
gs-3799	839	8	)	)	PUNCT
gs-3799	839	9	.	.	PUNCT
gs-3799	840	1	https://doi.org/10.52340/spectri.2023.08.02.03	https://doi.org/10.52340/spectri.2023.08.02.03	PROPN
gs-3799	840	2	33	33	NUM
gs-3799	840	3	.	.	PUNCT
gs-3799	841	1	aphkhazava	aphkhazava	PROPN
gs-3799	841	2	,	,	PUNCT
gs-3799	841	3	d.	d.	PROPN
gs-3799	841	4	,	,	PUNCT
gs-3799	841	5	tuphinashvili	tuphinashvili	NOUN
gs-3799	841	6	,	,	PUNCT
gs-3799	841	7	t.	t.	NOUN
gs-3799	841	8	,	,	PUNCT
gs-3799	841	9	sulashvili	sulashvili	NOUN
gs-3799	841	10	,	,	PUNCT
gs-3799	841	11	n.	n.	NOUN
gs-3799	841	12	,	,	PUNCT
gs-3799	841	13	&	&	CCONJ
gs-3799	841	14	nozadze	nozadze	NOUN
gs-3799	841	15	,	,	PUNCT
gs-3799	841	16	m.	m.	NOUN
gs-3799	841	17	(	(	PUNCT
gs-3799	841	18	2023	2023	NUM
gs-3799	841	19	)	)	PUNCT
gs-3799	841	20	.	.	PUNCT
gs-3799	842	1	the	the	DET
gs-3799	842	2	features	feature	NOUN
gs-3799	842	3	and	and	CCONJ
gs-3799	842	4	role	role	NOUN
gs-3799	842	5	of	of	ADP
gs-3799	842	6	shp2	shp2	ADJ
gs-3799	842	7	protein	protein	NOUN
gs-3799	842	8	in	in	ADP
gs-3799	842	9	postnatal	postnatal	ADJ
gs-3799	842	10	muscle	muscle	NOUN
gs-3799	842	11	development	development	NOUN
gs-3799	842	12	.	.	PUNCT
gs-3799	843	1	scientific	scientific	ADJ
gs-3799	843	2	journal	journal	NOUN
gs-3799	843	3	„	„	PUNCT
gs-3799	843	4	spectri	spectri	NOUN
gs-3799	843	5	“	"	PUNCT
gs-3799	843	6	,	,	PUNCT
gs-3799	843	7	1	1	X
gs-3799	843	8	.	.	PUNCT
gs-3799	844	1	https://doi.org/10.52340/spectri.2023.01	https://doi.org/10.52340/spectri.2023.01	DET
gs-3799	844	2	34	34	NUM
gs-3799	844	3	.	.	PUNCT
gs-3799	844	4	sulashvili	sulashvili	NOUN
gs-3799	844	5	,	,	PUNCT
gs-3799	844	6	n.	n.	NOUN
gs-3799	844	7	,	,	PUNCT
gs-3799	844	8	beglaryan	beglaryan	ADJ
gs-3799	844	9	,	,	PUNCT
gs-3799	844	10	m.	m.	NOUN
gs-3799	844	11	,	,	PUNCT
gs-3799	844	12	gorgaslidze	gorgaslidze	PROPN
gs-3799	844	13	,	,	PUNCT
gs-3799	844	14	n.	n.	PROPN
gs-3799	844	15	,	,	PUNCT
gs-3799	844	16	kocharyan	kocharyan	PROPN
gs-3799	844	17	,	,	PUNCT
gs-3799	844	18	s.	s.	PROPN
gs-3799	844	19	,	,	PUNCT
gs-3799	844	20	chichoyan	chichoyan	PROPN
gs-3799	844	21	,	,	PUNCT
gs-3799	844	22	n.	n.	NOUN
gs-3799	844	23	,	,	PUNCT
gs-3799	844	24	gabunia	gabunia	NOUN
gs-3799	844	25	,	,	PUNCT
gs-3799	844	26	l.	l.	PROPN
gs-3799	844	27	,	,	PUNCT
gs-3799	844	28	…	…	PUNCT
gs-3799	844	29	zarnadze	zarnadze	PROPN
gs-3799	844	30	,	,	PUNCT
gs-3799	844	31	s.	s.	PROPN
gs-3799	844	32	(	(	PUNCT
gs-3799	844	33	davit	davit	PROPN
gs-3799	844	34	)	)	PUNCT
gs-3799	844	35	.	.	PUNCT
gs-3799	845	1	(	(	PUNCT
gs-3799	845	2	2023	2023	NUM
gs-3799	845	3	)	)	PUNCT
gs-3799	845	4	.	.	PUNCT
gs-3799	846	1	the	the	DET
gs-3799	846	2	disclosure	disclosure	NOUN
gs-3799	846	3	of	of	ADP
gs-3799	846	4	features	feature	NOUN
gs-3799	846	5	,	,	PUNCT
gs-3799	846	6	characteristics	characteristic	NOUN
gs-3799	846	7	,	,	PUNCT
gs-3799	846	8	possibilities	possibility	NOUN
gs-3799	846	9	and	and	CCONJ
gs-3799	846	10	specialties	specialty	NOUN
gs-3799	846	11	of	of	ADP
gs-3799	846	12	clinical	clinical	ADJ
gs-3799	846	13	pharmacists	pharmacist	NOUN
gs-3799	846	14	as	as	ADP
gs-3799	846	15	mediator	mediator	NOUN
gs-3799	846	16	among	among	ADP
gs-3799	846	17	doctors	doctor	NOUN
gs-3799	846	18	and	and	CCONJ
gs-3799	846	19	patients	patient	NOUN
gs-3799	846	20	for	for	ADP
gs-3799	846	21	enhancement	enhancement	NOUN
gs-3799	846	22	public	public	ADJ
gs-3799	846	23	health	health	NOUN
gs-3799	846	24	sector	sector	NOUN
gs-3799	846	25	in	in	ADP
gs-3799	846	26	a	a	DET
gs-3799	846	27	global	global	ADJ
gs-3799	846	28	world	world	NOUN
gs-3799	846	29	.	.	PUNCT
gs-3799	847	1	experimental	experimental	ADJ
gs-3799	847	2	and	and	CCONJ
gs-3799	847	3	clinical	clinical	ADJ
gs-3799	847	4	medicine	medicine	NOUN
gs-3799	847	5	georgia	georgia	PROPN
gs-3799	847	6	,	,	PUNCT
gs-3799	847	7	(	(	PUNCT
gs-3799	847	8	4	4	NUM
gs-3799	847	9	)	)	PUNCT
gs-3799	847	10	,	,	PUNCT
gs-3799	847	11	57–62	57–62	NUM
gs-3799	847	12	.	.	PUNCT
gs-3799	848	1	https://doi.org/10.52340/jecm.2023.04.15	https://doi.org/10.52340/jecm.2023.04.15	PROPN
gs-3799	848	2	35	35	NUM
gs-3799	848	3	.	.	PUNCT
gs-3799	848	4	sulashvili	sulashvili	NOUN
gs-3799	848	5	,	,	PUNCT
gs-3799	848	6	n.	n.	NOUN
gs-3799	848	7	,	,	PUNCT
gs-3799	848	8	gorgaslidze	gorgaslidze	PROPN
gs-3799	848	9	,	,	PUNCT
gs-3799	848	10	n.	n.	NOUN
gs-3799	848	11	,	,	PUNCT
gs-3799	848	12	gabunia	gabunia	NOUN
gs-3799	848	13	,	,	PUNCT
gs-3799	848	14	l.	l.	PROPN
gs-3799	848	15	,	,	PUNCT
gs-3799	848	16	giorgobiani	giorgobiani	PROPN
gs-3799	848	17	,	,	PUNCT
gs-3799	848	18	m.	m.	NOUN
gs-3799	848	19	,	,	PUNCT
gs-3799	848	20	&	&	CCONJ
gs-3799	848	21	ratiani	ratiani	PROPN
gs-3799	848	22	,	,	PUNCT
gs-3799	848	23	l.	l.	PROPN
gs-3799	848	24	(	(	PUNCT
gs-3799	848	25	2023	2023	NUM
gs-3799	848	26	)	)	PUNCT
gs-3799	848	27	.	.	PUNCT
gs-3799	849	1	manifestation	manifestation	NOUN
gs-3799	849	2	of	of	ADP
gs-3799	849	3	the	the	DET
gs-3799	849	4	particularities	particularity	NOUN
gs-3799	849	5	of	of	ADP
gs-3799	849	6	the	the	DET
gs-3799	849	7	usage	usage	NOUN
gs-3799	849	8	features	feature	NOUN
gs-3799	849	9	of	of	ADP
gs-3799	849	10	monoclonal	monoclonal	NOUN
gs-3799	849	11	antibodies	antibody	NOUN
gs-3799	849	12	in	in	ADP
gs-3799	849	13	various	various	ADJ
gs-3799	849	14	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-3799	849	15	applications	application	NOUN
gs-3799	849	16	.	.	PUNCT
gs-3799	850	1	experimental	experimental	ADJ
gs-3799	850	2	and	and	CCONJ
gs-3799	850	3	clinical	clinical	ADJ
gs-3799	850	4	medicine	medicine	NOUN
gs-3799	850	5	georgia	georgia	PROPN
gs-3799	850	6	,	,	PUNCT
gs-3799	850	7	(	(	PUNCT
gs-3799	850	8	4	4	NUM
gs-3799	850	9	)	)	PUNCT
gs-3799	850	10	,	,	PUNCT
gs-3799	850	11	52–57	52–57	NUM
gs-3799	850	12	.	.	PUNCT
gs-3799	851	1	36	36	NUM
gs-3799	851	2	.	.	PUNCT
gs-3799	851	3	sulashvili	sulashvili	NOUN
gs-3799	851	4	,	,	PUNCT
gs-3799	851	5	n.	n.	NOUN
gs-3799	851	6	,	,	PUNCT
gs-3799	851	7	davitashvili	davitashvili	ADJ
gs-3799	851	8	,	,	PUNCT
gs-3799	851	9	m.	m.	NOUN
gs-3799	851	10	,	,	PUNCT
gs-3799	851	11	gorgaslidze	gorgaslidze	PROPN
gs-3799	851	12	,	,	PUNCT
gs-3799	851	13	n.	n.	NOUN
gs-3799	851	14	,	,	PUNCT
gs-3799	851	15	gabunia	gabunia	NOUN
gs-3799	851	16	,	,	PUNCT
gs-3799	851	17	l.	l.	PROPN
gs-3799	851	18	,	,	PUNCT
gs-3799	851	19	beglaryan	beglaryan	ADJ
gs-3799	851	20	,	,	PUNCT
gs-3799	851	21	m.	m.	NOUN
gs-3799	851	22	,	,	PUNCT
gs-3799	851	23	alavidze	alavidze	NOUN
gs-3799	851	24	,	,	PUNCT
gs-3799	851	25	n.	n.	NOUN
gs-3799	851	26	,	,	PUNCT
gs-3799	851	27	…	…	PUNCT
gs-3799	851	28	sulashvili	sulashvili	NOUN
gs-3799	851	29	,	,	PUNCT
gs-3799	851	30	m.	m.	NOUN
gs-3799	851	31	(	(	PUNCT
gs-3799	851	32	2024	2024	NUM
gs-3799	851	33	)	)	PUNCT
gs-3799	851	34	.	.	PUNCT
gs-3799	852	1	the	the	DET
gs-3799	852	2	scientific	scientific	ADJ
gs-3799	852	3	discussion	discussion	NOUN
gs-3799	852	4	of	of	ADP
gs-3799	852	5	some	some	DET
gs-3799	852	6	issues	issue	NOUN
gs-3799	852	7	of	of	ADP
gs-3799	852	8	features	feature	NOUN
gs-3799	852	9	and	and	CCONJ
gs-3799	852	10	challenges	challenge	NOUN
gs-3799	852	11	of	of	ADP
gs-3799	852	12	using	use	VERB
gs-3799	852	13	of	of	ADP
gs-3799	852	14	car	car	NOUN
gs-3799	852	15	-	-	PUNCT
gs-3799	852	16	t	t	NOUN
gs-3799	852	17	cells	cell	NOUN
gs-3799	852	18	in	in	ADP
gs-3799	852	19	immunotherapy	immunotherapy	NOUN
gs-3799	852	20	.	.	PUNCT
gs-3799	853	1	georgian	georgian	ADJ
gs-3799	853	2	scientists	scientist	NOUN
gs-3799	853	3	,	,	PUNCT
gs-3799	853	4	6(4	6(4	NOUN
gs-3799	853	5	)	)	PUNCT
gs-3799	853	6	,	,	PUNCT
gs-3799	853	7	263–290	263–290	NUM
gs-3799	853	8	.	.	PUNCT
gs-3799	854	1	https://doi.org/10.52340/gs.2024.06.04.24	https://doi.org/10.52340/gs.2024.06.04.24	PROPN
gs-3799	854	2	37	37	NUM
gs-3799	854	3	.	.	PUNCT
gs-3799	855	1	sulashvili	sulashvili	NOUN
gs-3799	855	2	,	,	PUNCT
gs-3799	855	3	n.	n.	NOUN
gs-3799	855	4	,	,	PUNCT
gs-3799	855	5	gorgaslidze	gorgaslidze	PROPN
gs-3799	855	6	,	,	PUNCT
gs-3799	855	7	n.	n.	NOUN
gs-3799	855	8	,	,	PUNCT
gs-3799	855	9	gabunia	gabunia	NOUN
gs-3799	855	10	,	,	PUNCT
gs-3799	855	11	l.	l.	PROPN
gs-3799	855	12	,	,	PUNCT
gs-3799	855	13	giorgobiani	giorgobiani	PROPN
gs-3799	855	14	,	,	PUNCT
gs-3799	855	15	m.	m.	NOUN
gs-3799	855	16	,	,	PUNCT
gs-3799	855	17	&	&	CCONJ
gs-3799	855	18	ratiani	ratiani	PROPN
gs-3799	855	19	,	,	PUNCT
gs-3799	855	20	l.	l.	PROPN
gs-3799	855	21	(	(	PUNCT
gs-3799	855	22	2023	2023	NUM
gs-3799	855	23	)	)	PUNCT
gs-3799	855	24	.	.	PUNCT
gs-3799	856	1	manifestation	manifestation	NOUN
gs-3799	856	2	of	of	ADP
gs-3799	856	3	the	the	DET
gs-3799	856	4	particularities	particularity	NOUN
gs-3799	856	5	of	of	ADP
gs-3799	856	6	the	the	DET
gs-3799	856	7	usage	usage	NOUN
gs-3799	856	8	features	feature	NOUN
gs-3799	856	9	of	of	ADP
gs-3799	856	10	monoclonal	monoclonal	NOUN
gs-3799	856	11	antibodies	antibody	NOUN
gs-3799	856	12	in	in	ADP
gs-3799	856	13	various	various	ADJ
gs-3799	856	14	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-3799	856	15	applications	application	NOUN
gs-3799	856	16	.	.	PUNCT
gs-3799	857	1	experimental	experimental	ADJ
gs-3799	857	2	and	and	CCONJ
gs-3799	857	3	clinical	clinical	ADJ
gs-3799	857	4	medicine	medicine	NOUN
gs-3799	857	5	georgia	georgia	PROPN
gs-3799	857	6	,	,	PUNCT
gs-3799	857	7	(	(	PUNCT
gs-3799	857	8	4	4	NUM
gs-3799	857	9	)	)	PUNCT
gs-3799	857	10	,	,	PUNCT
gs-3799	857	11	52–57	52–57	NUM
gs-3799	857	12	.	.	PUNCT
gs-3799	858	1	https://doi.org/10.52340/jecm.2023.04.14	https://doi.org/10.52340/jecm.2023.04.14	X
gs-3799	859	1	38	38	NUM
gs-3799	859	2	.	.	PUNCT
gs-3799	859	3	sulashvili	sulashvili	NOUN
gs-3799	859	4	,	,	PUNCT
gs-3799	859	5	n.	n.	NOUN
gs-3799	859	6	,	,	PUNCT
gs-3799	859	7	gorgaslidze	gorgaslidze	PROPN
gs-3799	859	8	,	,	PUNCT
gs-3799	859	9	n.	n.	NOUN
gs-3799	859	10	,	,	PUNCT
gs-3799	859	11	gabunia	gabunia	NOUN
gs-3799	859	12	,	,	PUNCT
gs-3799	859	13	l.	l.	PROPN
gs-3799	859	14	,	,	PUNCT
gs-3799	859	15	ratiani	ratiani	PROPN
gs-3799	859	16	,	,	PUNCT
gs-3799	859	17	l.	l.	PROPN
gs-3799	859	18	,	,	PUNCT
gs-3799	859	19	khetsuriani	khetsuriani	PROPN
gs-3799	859	20	,	,	PUNCT
gs-3799	859	21	s.	s.	PROPN
gs-3799	859	22	,	,	PUNCT
gs-3799	859	23	kravchenko	kravchenko	PROPN
gs-3799	859	24	,	,	PUNCT
gs-3799	859	25	v.	v.	NOUN
gs-3799	859	26	,	,	PUNCT
gs-3799	859	27	sulashvili	sulashvili	NOUN
gs-3799	859	28	,	,	PUNCT
gs-3799	859	29	m.	m.	NOUN
gs-3799	859	30	(	(	PUNCT
gs-3799	859	31	2024	2024	NUM
gs-3799	859	32	)	)	PUNCT
gs-3799	859	33	.	.	PUNCT
gs-3799	860	1	manifestation	manifestation	NOUN
gs-3799	860	2	of	of	ADP
gs-3799	860	3	the	the	DET
gs-3799	860	4	particularities	particularity	NOUN
gs-3799	860	5	of	of	ADP
gs-3799	860	6	some	some	DET
gs-3799	860	7	key	key	ADJ
gs-3799	860	8	issue	issue	NOUN
gs-3799	860	9	aspects	aspect	NOUN
gs-3799	860	10	of	of	ADP
gs-3799	860	11	new	new	ADJ
gs-3799	860	12	immunotherapy	immunotherapy	NOUN
gs-3799	860	13	challenges	challenge	NOUN
gs-3799	860	14	and	and	CCONJ
gs-3799	860	15	perspectives	perspective	NOUN
gs-3799	860	16	by	by	ADP
gs-3799	860	17	car	car	NOUN
gs-3799	860	18	-	-	PUNCT
gs-3799	860	19	t	t	NOUN
gs-3799	860	20	cell	cell	NOUN
gs-3799	860	21	therapy	therapy	NOUN
gs-3799	860	22	.	.	PUNCT
gs-3799	861	1	experimental	experimental	ADJ
gs-3799	861	2	and	and	CCONJ
gs-3799	861	3	clinical	clinical	ADJ
gs-3799	861	4	medicine	medicine	NOUN
gs-3799	861	5	georgia	georgia	PROPN
gs-3799	861	6	,	,	PUNCT
gs-3799	861	7	(	(	PUNCT
gs-3799	861	8	4	4	NUM
gs-3799	861	9	)	)	PUNCT
gs-3799	861	10	,	,	PUNCT
gs-3799	861	11	119–121	119–121	NUM
gs-3799	861	12	.	.	PUNCT
gs-3799	861	13	https://doi.org/10.52340/jecm.2024.04.32	https://doi.org/10.52340/jecm.2024.04.32	NUM
gs-3799	861	14	.	.	PUNCT
gs-3799	862	1	georgian	georgian	NOUN
gs-3799	862	2	scientists/	scientists/	NUM
gs-3799	862	3	.	.	PUNCT
gs-3799	863	1	7	7	NUM
gs-3799	863	2	n	n	PRON
gs-3799	863	3	2	2	NUM
gs-3799	863	4	,	,	PUNCT
gs-3799	863	5	2025	2025	NUM
gs-3799	863	6	419	419	NUM
gs-3799	863	7	39	39	NUM
gs-3799	863	8	.	.	PUNCT
gs-3799	864	1	sulashvili	sulashvili	NOUN
gs-3799	864	2	,	,	PUNCT
gs-3799	864	3	n.	n.	NOUN
gs-3799	864	4	.	.	PUNCT
gs-3799	865	1	.	.	PUNCT
gs-3799	865	2	,	,	PUNCT
gs-3799	866	1	gorgaslidze	gorgaslidze	INTJ
gs-3799	866	2	,	,	PUNCT
gs-3799	866	3	n.	n.	PROPN
gs-3799	866	4	.	.	PUNCT
gs-3799	867	1	,	,	PUNCT
gs-3799	867	2	beglaryan	beglaryan	ADJ
gs-3799	867	3	,	,	PUNCT
gs-3799	867	4	m.	m.	NOUN
gs-3799	867	5	.	.	PUNCT
gs-3799	867	6	,	,	PUNCT
gs-3799	867	7	gabunia	gabunia	NOUN
gs-3799	867	8	,	,	PUNCT
gs-3799	867	9	l.	l.	PROPN
gs-3799	867	10	.	.	PROPN
gs-3799	867	11	,	,	PUNCT
gs-3799	867	12	chichoyan	chichoyan	PROPN
gs-3799	867	13	,	,	PUNCT
gs-3799	867	14	n.	n.	PROPN
gs-3799	867	15	.	.	PUNCT
gs-3799	867	16	,	,	PUNCT
gs-3799	867	17	giorgobiani	giorgobiani	PROPN
gs-3799	867	18	,	,	PUNCT
gs-3799	867	19	m.	m.	NOUN
gs-3799	867	20	.	.	PUNCT
gs-3799	868	1	,	,	PUNCT
gs-3799	868	2	…	…	PUNCT
gs-3799	868	3	zarnadze	zarnadze	INTJ
gs-3799	868	4	,	,	PUNCT
gs-3799	868	5	s.	s.	PROPN
gs-3799	868	6	(	(	PUNCT
gs-3799	868	7	davit	davit	PROPN
gs-3799	868	8	)	)	PUNCT
gs-3799	868	9	.	.	PUNCT
gs-3799	869	1	(	(	PUNCT
gs-3799	869	2	2022	2022	NUM
gs-3799	869	3	)	)	PUNCT
gs-3799	869	4	.	.	PUNCT
gs-3799	870	1	the	the	DET
gs-3799	870	2	scientific	scientific	ADJ
gs-3799	870	3	talks	talk	NOUN
gs-3799	870	4	of	of	ADP
gs-3799	870	5	essential	essential	ADJ
gs-3799	870	6	issue	issue	NOUN
gs-3799	870	7	,	,	PUNCT
gs-3799	870	8	invocation	invocation	NOUN
gs-3799	870	9	,	,	PUNCT
gs-3799	870	10	perspectives	perspective	NOUN
gs-3799	870	11	,	,	PUNCT
gs-3799	870	12	inclinations	inclination	NOUN
gs-3799	870	13	and	and	CCONJ
gs-3799	870	14	features	feature	NOUN
gs-3799	870	15	of	of	ADP
gs-3799	870	16	the	the	DET
gs-3799	870	17	clinical	clinical	ADJ
gs-3799	870	18	pharmacists	pharmacist	NOUN
gs-3799	870	19	globally	globally	ADV
gs-3799	870	20	.	.	PUNCT
gs-3799	871	1	experimental	experimental	ADJ
gs-3799	871	2	and	and	CCONJ
gs-3799	871	3	clinical	clinical	ADJ
gs-3799	871	4	medicine	medicine	NOUN
gs-3799	871	5	georgia	georgia	PROPN
gs-3799	871	6	,	,	PUNCT
gs-3799	871	7	(	(	PUNCT
gs-3799	871	8	7	7	NUM
gs-3799	871	9	)	)	PUNCT
gs-3799	871	10	.	.	PUNCT
gs-3799	872	1	40	40	NUM
gs-3799	872	2	.	.	PUNCT
gs-3799	873	1	sulashvili	sulashvili	PROPN
gs-3799	873	2	n	n	CCONJ
gs-3799	873	3	,	,	PUNCT
gs-3799	873	4	nimangre	nimangre	PROPN
gs-3799	873	5	rr	rr	PROPN
gs-3799	873	6	.	.	PUNCT
gs-3799	874	1	manifestation	manifestation	NOUN
gs-3799	874	2	of	of	ADP
gs-3799	874	3	some	some	DET
gs-3799	874	4	aspects	aspect	NOUN
gs-3799	874	5	of	of	ADP
gs-3799	874	6	cardiovascular	cardiovascular	ADJ
gs-3799	874	7	diseases	disease	NOUN
gs-3799	874	8	,	,	PUNCT
gs-3799	874	9	implications	implication	NOUN
gs-3799	874	10	,	,	PUNCT
gs-3799	874	11	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-3799	874	12	strategies	strategy	NOUN
gs-3799	874	13	,	,	PUNCT
gs-3799	874	14	effects	effect	NOUN
gs-3799	874	15	,	,	PUNCT
gs-3799	874	16	impacts	impact	NOUN
gs-3799	874	17	and	and	CCONJ
gs-3799	874	18	potential	potential	ADJ
gs-3799	874	19	hazards	hazard	NOUN
gs-3799	874	20	in	in	ADP
gs-3799	874	21	general	general	ADJ
gs-3799	874	22	.	.	PUNCT
gs-3799	875	1	jr	jr	PROPN
gs-3799	876	1	[	[	X
gs-3799	876	2	internet	internet	NOUN
gs-3799	876	3	]	]	PUNCT
gs-3799	876	4	.	.	PUNCT
gs-3799	877	1	2025	2025	NUM
gs-3799	877	2	feb	feb	X
gs-3799	877	3	.	.	PROPN
gs-3799	877	4	7	7	NUM
gs-3799	877	5	[	[	X
gs-3799	877	6	cited	cite	VERB
gs-3799	877	7	2025	2025	NUM
gs-3799	877	8	may	may	PROPN
gs-3799	877	9	22];3(1):1	22];3(1):1	NUM
gs-3799	877	10	-	-	SYM
gs-3799	877	11	27	27	NUM
gs-3799	877	12	.	.	PUNCT
gs-3799	878	1	available	available	ADJ
gs-3799	878	2	from	from	ADP
gs-3799	878	3	:	:	PUNCT
gs-3799	878	4	https://journals.4science.ge/index.php/jr/article/view/3393	https://journals.4science.ge/index.php/jr/article/view/3393	PROPN
gs-3799	878	5	.	.	PUNCT
gs-3799	879	1	41	41	NUM
gs-3799	879	2	.	.	PUNCT
gs-3799	880	1	sulashvili	sulashvili	PROPN
gs-3799	880	2	n	n	CCONJ
gs-3799	880	3	,	,	PUNCT
gs-3799	880	4	yaduvanshi	yaduvanshi	NOUN
gs-3799	880	5	u	u	NOUN
gs-3799	880	6	,	,	PUNCT
gs-3799	880	7	yadav	yadav	PROPN
gs-3799	880	8	m	m	PROPN
gs-3799	880	9	,	,	PUNCT
gs-3799	880	10	gabunia	gabunia	NOUN
gs-3799	880	11	l	l	NOUN
gs-3799	880	12	,	,	PUNCT
gs-3799	880	13	ghambashidze	ghambashidze	PROPN
gs-3799	880	14	k	k	PROPN
gs-3799	880	15	,	,	PUNCT
gs-3799	880	16	gorgaslidze	gorgaslidze	ADJ
gs-3799	880	17	n	n	CCONJ
gs-3799	880	18	,	,	PUNCT
gs-3799	880	19	et	et	PROPN
gs-3799	880	20	al	al	PROPN
gs-3799	880	21	.	.	PUNCT
gs-3799	881	1	the	the	DET
gs-3799	881	2	scientific	scientific	ADJ
gs-3799	881	3	discourse	discourse	NOUN
gs-3799	881	4	of	of	ADP
gs-3799	881	5	features	feature	NOUN
gs-3799	881	6	of	of	ADP
gs-3799	881	7	clinical	clinical	ADJ
gs-3799	881	8	use	use	NOUN
gs-3799	881	9	and	and	CCONJ
gs-3799	881	10	pharmacology	pharmacology	NOUN
gs-3799	881	11	of	of	ADP
gs-3799	881	12	vasoconstrictors	vasoconstrictor	NOUN
gs-3799	881	13	and	and	CCONJ
gs-3799	881	14	their	their	PRON
gs-3799	881	15	impact	impact	NOUN
gs-3799	881	16	on	on	ADP
gs-3799	881	17	cardiac	cardiac	ADJ
gs-3799	881	18	function	function	NOUN
gs-3799	881	19	.	.	PUNCT
gs-3799	882	1	jr	jr	PROPN
gs-3799	883	1	[	[	X
gs-3799	883	2	internet	internet	NOUN
gs-3799	883	3	]	]	PUNCT
gs-3799	883	4	.	.	PUNCT
gs-3799	884	1	2025	2025	NUM
gs-3799	884	2	feb	feb	X
gs-3799	884	3	.	.	PROPN
gs-3799	884	4	21	21	NUM
gs-3799	884	5	[	[	X
gs-3799	884	6	cited	cite	VERB
gs-3799	884	7	2025	2025	NUM
gs-3799	884	8	may	may	PROPN
gs-3799	884	9	22];3(1):28	22];3(1):28	NUM
gs-3799	884	10	-	-	SYM
gs-3799	884	11	6	6	NUM
gs-3799	884	12	.	.	PUNCT
gs-3799	885	1	available	available	ADJ
gs-3799	885	2	from	from	ADP
gs-3799	885	3	:	:	PUNCT
gs-3799	885	4	https://journals.4science.ge/index.php/jr/article/view/3414	https://journals.4science.ge/index.php/jr/article/view/3414	NOUN
gs-3799	885	5	.	.	PUNCT
gs-3799	886	1	42	42	NUM
gs-3799	886	2	.	.	PUNCT
gs-3799	887	1	nodar	nodar	PROPN
gs-3799	887	2	sulashvili	sulashvili	NOUN
gs-3799	887	3	,	,	PUNCT
gs-3799	887	4	nana	nana	PROPN
gs-3799	887	5	gorgaslidze	gorgaslidze	PROPN
gs-3799	887	6	,	,	PUNCT
gs-3799	887	7	margarita	margarita	PROPN
gs-3799	887	8	beglaryan	beglaryan	PROPN
gs-3799	887	9	,	,	PUNCT
gs-3799	887	10	luiza	luiza	PROPN
gs-3799	887	11	gabunia	gabunia	PROPN
gs-3799	887	12	,	,	PUNCT
gs-3799	887	13	nato	nato	PROPN
gs-3799	887	14	alavidze	alavidze	PROPN
gs-3799	887	15	,	,	PUNCT
gs-3799	887	16	nino	nino	PROPN
gs-3799	887	17	abuladze	abuladze	PROPN
gs-3799	887	18	,	,	PUNCT
gs-3799	887	19	marina	marina	PROPN
gs-3799	887	20	giorgobiani	giorgobiani	PROPN
gs-3799	887	21	,	,	PUNCT
gs-3799	887	22	marika	marika	PROPN
gs-3799	887	23	sulashvili	sulashvili	PROPN
gs-3799	887	24	,	,	PUNCT
gs-3799	887	25	tamar	tamar	PROPN
gs-3799	887	26	okropiridze	okropiridze	PROPN
gs-3799	887	27	,	,	PUNCT
gs-3799	887	28	and	and	CCONJ
gs-3799	887	29	lali	lali	PROPN
gs-3799	887	30	patsia	patsia	PROPN
gs-3799	887	31	.	.	PUNCT
gs-3799	888	1	2025	2025	NUM
gs-3799	888	2	.	.	PUNCT
gs-3799	889	1	“	"	PUNCT
gs-3799	889	2	the	the	DET
gs-3799	889	3	scientific	scientific	ADJ
gs-3799	889	4	discourse	discourse	NOUN
gs-3799	889	5	of	of	ADP
gs-3799	889	6	key	key	ADJ
gs-3799	889	7	issue	issue	NOUN
gs-3799	889	8	aspects	aspect	NOUN
gs-3799	889	9	of	of	ADP
gs-3799	889	10	features	feature	NOUN
gs-3799	889	11	of	of	ADP
gs-3799	889	12	candida	candida	PROPN
gs-3799	889	13	problems	problem	NOUN
gs-3799	889	14	,	,	PUNCT
gs-3799	889	15	antifungal	antifungal	ADJ
gs-3799	889	16	drugs	drug	NOUN
gs-3799	889	17	resistance	resistance	NOUN
gs-3799	889	18	concerns	concern	NOUN
gs-3799	889	19	,	,	PUNCT
gs-3799	889	20	mycotoxicology	mycotoxicology	NOUN
gs-3799	889	21	issues	issue	NOUN
gs-3799	889	22	,	,	PUNCT
gs-3799	889	23	mycoecology	mycoecology	NOUN
gs-3799	889	24	,	,	PUNCT
gs-3799	889	25	biosafety	biosafety	NOUN
gs-3799	889	26	risks	risk	NOUN
gs-3799	889	27	and	and	CCONJ
gs-3799	889	28	emerging	emerge	VERB
gs-3799	889	29	solutions	solution	NOUN
gs-3799	889	30	”	"	PUNCT
gs-3799	889	31	.	.	PUNCT
gs-3799	890	1	modern	modern	ADJ
gs-3799	890	2	scientific	scientific	ADJ
gs-3799	890	3	method	method	NOUN
gs-3799	890	4	,	,	PUNCT
gs-3799	890	5	no	no	INTJ
gs-3799	890	6	.	.	NOUN
gs-3799	890	7	9	9	NUM
gs-3799	890	8	(	(	PUNCT
gs-3799	890	9	march	march	PROPN
gs-3799	890	10	)	)	PUNCT
gs-3799	890	11	.	.	PUNCT
gs-3799	891	1	https://ojs.scipub.de/index.php/msm/article/view/5423	https://ojs.scipub.de/index.php/msm/article/view/5423	NOUN
gs-3799	891	2	.	.	NOUN
gs-3799	892	1	43	43	NUM
gs-3799	892	2	.	.	PUNCT
gs-3799	893	1	andersen	andersen	PROPN
gs-3799	893	2	,	,	PUNCT
gs-3799	893	3	lars	lars	PROPN
gs-3799	893	4	m.	m.	PROPN
gs-3799	893	5	,	,	PUNCT
gs-3799	893	6	priya	priya	PROPN
gs-3799	893	7	mathur	mathur	PROPN
gs-3799	893	8	,	,	PUNCT
gs-3799	893	9	and	and	CCONJ
gs-3799	893	10	elena	elena	PROPN
gs-3799	893	11	rossi	rossi	PROPN
gs-3799	893	12	.	.	PROPN
gs-3799	893	13	2024	2024	NUM
gs-3799	893	14	.	.	PUNCT
gs-3799	894	1	"	"	PUNCT
gs-3799	894	2	biocompatible	biocompatible	ADJ
gs-3799	894	3	circuit	circuit	NOUN
gs-3799	894	4	coatings	coating	NOUN
gs-3799	894	5	and	and	CCONJ
gs-3799	894	6	closed	closed	ADJ
gs-3799	894	7	-	-	PUNCT
gs-3799	894	8	loop	loop	NOUN
gs-3799	894	9	anticoagulation	anticoagulation	NOUN
gs-3799	894	10	:	:	PUNCT
gs-3799	894	11	synergistic	synergistic	ADJ
gs-3799	894	12	effects	effect	NOUN
gs-3799	894	13	on	on	ADP
gs-3799	894	14	inflammation	inflammation	NOUN
gs-3799	894	15	and	and	CCONJ
gs-3799	894	16	thrombosis	thrombosis	NOUN
gs-3799	894	17	in	in	ADP
gs-3799	894	18	cardiac	cardiac	ADJ
gs-3799	894	19	surgery	surgery	NOUN
gs-3799	894	20	.	.	PUNCT
gs-3799	894	21	"	"	PUNCT
gs-3799	895	1	asaio	asaio	ADJ
gs-3799	895	2	journal	journal	NOUN
gs-3799	895	3	70	70	NUM
gs-3799	895	4	,	,	PUNCT
gs-3799	895	5	no	no	INTJ
gs-3799	895	6	.	.	NOUN
gs-3799	895	7	6	6	NUM
gs-3799	895	8	(	(	PUNCT
gs-3799	895	9	june	june	PROPN
gs-3799	895	10	):	):	PUNCT
gs-3799	895	11	487–495	487–495	NUM
gs-3799	895	12	.	.	PUNCT
gs-3799	896	1	44	44	NUM
gs-3799	896	2	.	.	PUNCT
gs-3799	896	3	dane	dane	PROPN
gs-3799	896	4	,	,	PUNCT
gs-3799	896	5	kathryn	kathryn	PROPN
gs-3799	896	6	,	,	PUNCT
gs-3799	896	7	and	and	CCONJ
gs-3799	896	8	allison	allison	PROPN
gs-3799	896	9	burnett	burnett	PROPN
gs-3799	896	10	.	.	PUNCT
gs-3799	897	1	2025	2025	NUM
gs-3799	897	2	.	.	PUNCT
gs-3799	898	1	"	"	PUNCT
gs-3799	898	2	pharmacogenomics	pharmacogenomic	NOUN
gs-3799	898	3	in	in	ADP
gs-3799	898	4	perioperative	perioperative	ADJ
gs-3799	898	5	anticoagulation	anticoagulation	NOUN
gs-3799	898	6	:	:	PUNCT
gs-3799	898	7	implications	implication	NOUN
gs-3799	898	8	for	for	ADP
gs-3799	898	9	automated	automate	VERB
gs-3799	898	10	cpb	cpb	PROPN
gs-3799	898	11	systems	system	NOUN
gs-3799	898	12	.	.	PUNCT
gs-3799	898	13	"	"	PUNCT
gs-3799	899	1	in	in	ADP
gs-3799	899	2	*	*	PROPN
gs-3799	899	3	psap	psap	PROPN
gs-3799	899	4	2025	2025	NUM
gs-3799	899	5	book	book	NOUN
gs-3799	899	6	1	1	NUM
gs-3799	899	7	(	(	PUNCT
gs-3799	899	8	cardiology	cardiology	NOUN
gs-3799	899	9	):	):	PUNCT
gs-3799	899	10	pharmacotherapy	pharmacotherapy	NOUN
gs-3799	899	11	self	self	NOUN
gs-3799	899	12	-	-	PUNCT
gs-3799	899	13	assessment	assessment	NOUN
gs-3799	899	14	program	program	NOUN
gs-3799	899	15	*	*	PUNCT
gs-3799	899	16	,	,	PUNCT
gs-3799	899	17	edited	edit	VERB
gs-3799	899	18	by	by	ADP
gs-3799	899	19	nicholas	nicholas	PROPN
gs-3799	899	20	w.	w.	PROPN
gs-3799	899	21	carris	carris	PROPN
gs-3799	899	22	,	,	PUNCT
gs-3799	899	23	201–218	201–218	NUM
gs-3799	899	24	.	.	PROPN
gs-3799	899	25	45	45	NUM
gs-3799	899	26	.	.	PUNCT
gs-3799	899	27	european	european	ADJ
gs-3799	899	28	society	society	NOUN
gs-3799	899	29	of	of	ADP
gs-3799	899	30	cardio	cardio	NOUN
gs-3799	899	31	-	-	PUNCT
gs-3799	899	32	thoracic	thoracic	NOUN
gs-3799	899	33	surgeons	surgeon	NOUN
gs-3799	899	34	(	(	PUNCT
gs-3799	899	35	eacts	eact	NOUN
gs-3799	899	36	)	)	PUNCT
gs-3799	899	37	.	.	PUNCT
gs-3799	900	1	2023	2023	NUM
gs-3799	900	2	.	.	PUNCT
gs-3799	901	1	guidelines	guideline	NOUN
gs-3799	901	2	for	for	ADP
gs-3799	901	3	real	real	ADJ
gs-3799	901	4	-	-	PUNCT
gs-3799	901	5	time	time	NOUN
gs-3799	901	6	monitoring	monitoring	NOUN
gs-3799	901	7	and	and	CCONJ
gs-3799	901	8	automated	automate	VERB
gs-3799	901	9	control	control	NOUN
gs-3799	901	10	in	in	ADP
gs-3799	901	11	extracorporeal	extracorporeal	NOUN
gs-3799	901	12	circulation	circulation	NOUN
gs-3799	901	13	.	.	PUNCT
gs-3799	902	1	eacts	eact	VERB
gs-3799	902	2	technical	technical	PROPN
gs-3799	902	3	standards	standards	PROPN
gs-3799	902	4	committee	committee	NOUN
gs-3799	902	5	.	.	PUNCT
gs-3799	903	1	46	46	NUM
gs-3799	903	2	.	.	PUNCT
gs-3799	904	1	kato	kato	PROPN
gs-3799	904	2	,	,	PUNCT
gs-3799	904	3	hiroko	hiroko	PROPN
gs-3799	904	4	,	,	PUNCT
gs-3799	904	5	rajiv	rajiv	PROPN
gs-3799	904	6	singh	singh	PROPN
gs-3799	904	7	,	,	PUNCT
gs-3799	904	8	and	and	CCONJ
gs-3799	904	9	marco	marco	PROPN
gs-3799	904	10	de	de	PROPN
gs-3799	904	11	andrade	andrade	PROPN
gs-3799	904	12	.	.	PROPN
gs-3799	904	13	2024	2024	NUM
gs-3799	904	14	.	.	PUNCT
gs-3799	905	1	"	"	PUNCT
gs-3799	905	2	closed	closed	ADJ
gs-3799	905	3	-	-	PUNCT
gs-3799	905	4	loop	loop	NOUN
gs-3799	905	5	vasoactive	vasoactive	ADJ
gs-3799	905	6	drug	drug	NOUN
gs-3799	905	7	delivery	delivery	NOUN
gs-3799	905	8	in	in	ADP
gs-3799	905	9	high	high	ADJ
gs-3799	905	10	-	-	PUNCT
gs-3799	905	11	risk	risk	NOUN
gs-3799	905	12	cardiac	cardiac	ADJ
gs-3799	905	13	surgery	surgery	NOUN
gs-3799	905	14	:	:	PUNCT
gs-3799	905	15	impact	impact	NOUN
gs-3799	905	16	on	on	ADP
gs-3799	905	17	hemynamic	hemynamic	ADJ
gs-3799	905	18	stability	stability	NOUN
gs-3799	905	19	and	and	CCONJ
gs-3799	905	20	organ	organ	NOUN
gs-3799	905	21	perfusion	perfusion	NOUN
gs-3799	905	22	.	.	PUNCT
gs-3799	905	23	"	"	PUNCT
gs-3799	906	1	journal	journal	NOUN
gs-3799	906	2	of	of	ADP
gs-3799	906	3	cardiothoracic	cardiothoracic	NOUN
gs-3799	906	4	and	and	CCONJ
gs-3799	906	5	vascular	vascular	VERB
gs-3799	906	6	anesthesia	anesthesia	NOUN
gs-3799	906	7	38	38	NUM
gs-3799	906	8	,	,	PUNCT
gs-3799	906	9	no	no	INTJ
gs-3799	906	10	.	.	NOUN
gs-3799	906	11	7	7	NUM
gs-3799	906	12	(	(	PUNCT
gs-3799	906	13	july	july	PROPN
gs-3799	906	14	):	):	PUNCT
gs-3799	906	15	1623–1631	1623–1631	NUM
gs-3799	906	16	.	.	PUNCT
gs-3799	907	1	47	47	NUM
gs-3799	907	2	.	.	PUNCT
gs-3799	908	1	yamamoto	yamamoto	PROPN
gs-3799	908	2	,	,	PUNCT
gs-3799	908	3	kenji	kenji	PROPN
gs-3799	908	4	,	,	PUNCT
gs-3799	908	5	lisa	lisa	PROPN
gs-3799	908	6	m.	m.	PROPN
gs-3799	908	7	peterson	peterson	PROPN
gs-3799	908	8	,	,	PUNCT
gs-3799	908	9	and	and	CCONJ
gs-3799	908	10	michael	michael	PROPN
gs-3799	908	11	chang	chang	PROPN
gs-3799	908	12	.	.	PUNCT
gs-3799	908	13	2025	2025	NUM
gs-3799	908	14	.	.	PUNCT
gs-3799	909	1	"	"	PUNCT
gs-3799	909	2	artificial	artificial	ADJ
gs-3799	909	3	intelligence	intelligence	NOUN
gs-3799	909	4	for	for	ADP
gs-3799	909	5	predictive	predictive	ADJ
gs-3799	909	6	heparin	heparin	ADJ
gs-3799	909	7	-	-	PUNCT
gs-3799	909	8	protamine	protamine	NOUN
gs-3799	909	9	titration	titration	NOUN
gs-3799	909	10	in	in	ADP
gs-3799	909	11	pediatric	pediatric	ADJ
gs-3799	909	12	cardiopulmonary	cardiopulmonary	ADJ
gs-3799	909	13	bypass	bypass	NOUN
gs-3799	909	14	.	.	PUNCT
gs-3799	909	15	"	"	PUNCT
gs-3799	910	1	pediatric	pediatric	ADJ
gs-3799	910	2	critical	critical	ADJ
gs-3799	910	3	care	care	NOUN
gs-3799	910	4	medicine	medicine	NOUN
gs-3799	910	5	26	26	NUM
gs-3799	910	6	,	,	PUNCT
gs-3799	910	7	no	no	INTJ
gs-3799	910	8	.	.	NOUN
gs-3799	910	9	2	2	NUM
gs-3799	910	10	(	(	PUNCT
gs-3799	910	11	february	february	PROPN
gs-3799	910	12	):	):	PUNCT
gs-3799	910	13	e78	e78	PROPN
gs-3799	910	14	–	–	PUNCT
gs-3799	910	15	e88	e88	NOUN
gs-3799	910	16	.	.	PUNCT