id	sid	tid	token	lemma	pos
gs-3960	1	1	2025070325.pdf	2025070325.pdf	ADJ
gs-3960	1	2	georgian	georgian	NOUN
gs-3960	1	3	scientists/	scientists/	NUM
gs-3960	1	4	.	.	PUNCT
gs-3960	2	1	7	7	NUM
gs-3960	2	2	n	n	PRON
gs-3960	2	3	3	3	NUM
gs-3960	2	4	,	,	PUNCT
gs-3960	2	5	2025	2025	NUM
gs-3960	2	6	397	397	NUM
gs-3960	2	7	georgian	georgian	ADJ
gs-3960	2	8	scientists	scientist	NOUN
gs-3960	2	9	vol	vol	NOUN
gs-3960	2	10	.	.	PUNCT
gs-3960	2	11	7	7	NUM
gs-3960	2	12	issue	issue	NOUN
gs-3960	2	13	3	3	NUM
gs-3960	2	14	,	,	PUNCT
gs-3960	2	15	2025	2025	NUM
gs-3960	2	16	https://doi.org/10.52340/gs.2025.07.03.25	https://doi.org/10.52340/gs.2025.07.03.25	NOUN
gs-3960	2	17	the	the	DET
gs-3960	2	18	scientific	scientific	ADJ
gs-3960	2	19	discussion	discussion	NOUN
gs-3960	2	20	of	of	ADP
gs-3960	2	21	key	key	ADJ
gs-3960	2	22	issue	issue	NOUN
gs-3960	2	23	aspects	aspect	NOUN
gs-3960	2	24	of	of	ADP
gs-3960	2	25	mitochondrial	mitochondrial	ADJ
gs-3960	2	26	dysfunction	dysfunction	NOUN
gs-3960	2	27	and	and	CCONJ
gs-3960	2	28	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-3960	2	29	management	management	NOUN
gs-3960	2	30	strategies	strategy	NOUN
gs-3960	2	31	in	in	ADP
gs-3960	2	32	parkinson	parkinson	NOUN
gs-3960	2	33	's	's	PART
gs-3960	2	34	disease	disease	NOUN
gs-3960	2	35	:	:	PUNCT
gs-3960	2	36	focus	focus	VERB
gs-3960	2	37	on	on	ADP
gs-3960	2	38	mitophagy	mitophagy	NOUN
gs-3960	2	39	and	and	CCONJ
gs-3960	2	40	nad+	nad+	PROPN
gs-3960	2	41	metabolism	metabolism	NOUN
gs-3960	2	42	nodar	nodar	NOUN
gs-3960	2	43	sulashvili1	sulashvili1	PROPN
gs-3960	2	44	,	,	PUNCT
gs-3960	2	45	elene	elene	NOUN
gs-3960	2	46	abzianidze2	abzianidze2	PROPN
gs-3960	2	47	,	,	PUNCT
gs-3960	2	48	margarita	margarita	PROPN
gs-3960	2	49	beglaryan3	beglaryan3	PROPN
gs-3960	2	50	,	,	PUNCT
gs-3960	2	51	luiza	luiza	PROPN
gs-3960	2	52	gabunia4	gabunia4	PROPN
gs-3960	2	53	,	,	PUNCT
gs-3960	2	54	nana	nana	PROPN
gs-3960	2	55	gorgaslidze5	gorgaslidze5	PROPN
gs-3960	2	56	,	,	PUNCT
gs-3960	2	57	nato	nato	PROPN
gs-3960	2	58	alavidze6	alavidze6	PROPN
gs-3960	2	59	,	,	PUNCT
gs-3960	2	60	tharaka	tharaka	NOUN
gs-3960	2	61	srinatha	srinatha	PROPN
gs-3960	3	1	dunuwila7	dunuwila7	PROPN
gs-3960	3	2	,	,	PUNCT
gs-3960	3	3	kshitij	kshitij	PROPN
gs-3960	3	4	kumar8	kumar8	PROPN
gs-3960	3	5	,	,	PUNCT
gs-3960	3	6	jugal	jugal	PROPN
gs-3960	3	7	kishore9	kishore9	PROPN
gs-3960	3	8	,	,	PUNCT
gs-3960	3	9	ketevan	ketevan	NOUN
gs-3960	3	10	ghambashidze10	ghambashidze10	NOUN
gs-3960	3	11	,	,	PUNCT
gs-3960	3	12	marika	marika	PROPN
gs-3960	3	13	sulashvili11	sulashvili11	NOUN
gs-3960	3	14	,	,	PUNCT
gs-3960	3	15	lela	lela	PROPN
gs-3960	3	16	grigolia12	grigolia12	NOUN
gs-3960	3	17	,	,	PUNCT
gs-3960	3	18	kakhaber	kakhaber	PROPN
gs-3960	3	19	robakidze13	robakidze13	PROPN
gs-3960	3	20	,	,	PUNCT
gs-3960	3	21	irine	irine	PROPN
gs-3960	3	22	zarnadze14	zarnadze14	PROPN
gs-3960	3	23	,	,	PUNCT
gs-3960	3	24	shalva	shalva	NOUN
gs-3960	3	25	(	(	PUNCT
gs-3960	3	26	davit	davit	PROPN
gs-3960	3	27	)	)	PUNCT
gs-3960	3	28	zarnadze15	zarnadze15	PROPN
gs-3960	3	29	,	,	PUNCT
gs-3960	3	30	david	david	PROPN
gs-3960	3	31	aphkhazava16	aphkhazava16	PROPN
gs-3960	3	32	1md	1md	PROPN
gs-3960	3	33	,	,	PUNCT
gs-3960	3	34	phd	phd	NOUN
gs-3960	3	35	,	,	PUNCT
gs-3960	3	36	doctor	doctor	NOUN
gs-3960	3	37	of	of	ADP
gs-3960	3	38	pharmaceutical	pharmaceutical	ADJ
gs-3960	3	39	and	and	CCONJ
gs-3960	3	40	pharmacological	pharmacological	ADJ
gs-3960	3	41	sciences	science	NOUN
gs-3960	3	42	in	in	ADP
gs-3960	3	43	medicine	medicine	NOUN
gs-3960	3	44	,	,	PUNCT
gs-3960	3	45	invited	invite	VERB
gs-3960	3	46	lecturer	lecturer	NOUN
gs-3960	3	47	(	(	PUNCT
gs-3960	3	48	invited	invite	VERB
gs-3960	3	49	professor	professor	NOUN
gs-3960	3	50	)	)	PUNCT
gs-3960	3	51	of	of	ADP
gs-3960	3	52	scientific	scientific	ADJ
gs-3960	3	53	research	research	NOUN
gs-3960	3	54	-	-	PUNCT
gs-3960	3	55	skills	skill	NOUN
gs-3960	3	56	center	center	NOUN
gs-3960	3	57	at	at	ADP
gs-3960	3	58	tbilisi	tbilisi	PROPN
gs-3960	3	59	state	state	PROPN
gs-3960	3	60	medical	medical	PROPN
gs-3960	3	61	university	university	PROPN
gs-3960	3	62	;	;	PUNCT
gs-3960	3	63	professor	professor	NOUN
gs-3960	3	64	of	of	ADP
gs-3960	3	65	medical	medical	ADJ
gs-3960	3	66	and	and	CCONJ
gs-3960	3	67	clinical	clinical	ADJ
gs-3960	3	68	pharmacology	pharmacology	NOUN
gs-3960	3	69	of	of	ADP
gs-3960	3	70	international	international	ADJ
gs-3960	3	71	school	school	NOUN
gs-3960	3	72	of	of	ADP
gs-3960	3	73	medicine	medicine	NOUN
gs-3960	3	74	at	at	ADP
gs-3960	3	75	alte	alte	PROPN
gs-3960	3	76	university	university	PROPN
gs-3960	3	77	;	;	PUNCT
gs-3960	3	78	professor	professor	NOUN
gs-3960	3	79	of	of	ADP
gs-3960	3	80	pharmacology	pharmacology	NOUN
gs-3960	3	81	of	of	ADP
gs-3960	3	82	faculty	faculty	NOUN
gs-3960	3	83	of	of	ADP
gs-3960	3	84	medicine	medicine	NOUN
gs-3960	3	85	at	at	ADP
gs-3960	3	86	georgian	georgian	PROPN
gs-3960	3	87	national	national	PROPN
gs-3960	3	88	university	university	PROPN
gs-3960	3	89	seu	seu	PROPN
gs-3960	3	90	;	;	PUNCT
gs-3960	3	91	tbilisi	tbilisi	PROPN
gs-3960	3	92	,	,	PUNCT
gs-3960	3	93	georgia	georgia	PROPN
gs-3960	3	94	;	;	PUNCT
gs-3960	3	95	orcid	orcid	PROPN
gs-3960	3	96	https://orcid.org/0000-0002-9005-8577	https://orcid.org/0000-0002-9005-8577	PROPN
gs-3960	3	97	;	;	PUNCT
gs-3960	3	98	e	e	X
gs-3960	3	99	-	-	NOUN
gs-3960	3	100	mail	mail	NOUN
gs-3960	3	101	:	:	PUNCT
gs-3960	3	102	n.sulashvili@ug.edu.ge	n.sulashvili@ug.edu.ge	PROPN
gs-3960	3	103	2phd	2phd	NOUN
gs-3960	3	104	,	,	PUNCT
gs-3960	3	105	doctor	doctor	NOUN
gs-3960	3	106	of	of	ADP
gs-3960	3	107	biological	biological	ADJ
gs-3960	3	108	sciences	science	NOUN
gs-3960	3	109	,	,	PUNCT
gs-3960	3	110	academician	academician	NOUN
gs-3960	3	111	,	,	PUNCT
gs-3960	3	112	emeritus	emeritus	ADJ
gs-3960	3	113	professor	professor	NOUN
gs-3960	3	114	of	of	ADP
gs-3960	3	115	tbilisi	tbilisi	PROPN
gs-3960	3	116	state	state	PROPN
gs-3960	3	117	medical	medical	PROPN
gs-3960	3	118	university	university	PROPN
gs-3960	3	119	,	,	PUNCT
gs-3960	3	120	department	department	NOUN
gs-3960	3	121	of	of	ADP
gs-3960	3	122	molecular	molecular	ADJ
gs-3960	3	123	and	and	CCONJ
gs-3960	3	124	medical	medical	ADJ
gs-3960	3	125	genetics	genetic	NOUN
gs-3960	3	126	;	;	PUNCT
gs-3960	3	127	tbilisi	tbilisi	PROPN
gs-3960	3	128	,	,	PUNCT
gs-3960	3	129	georgia	georgia	PROPN
gs-3960	3	130	.	.	PUNCT
gs-3960	4	1	3md	3md	PROPN
gs-3960	4	2	,	,	PUNCT
gs-3960	4	3	phd	phd	NOUN
gs-3960	4	4	,	,	PUNCT
gs-3960	4	5	doctor	doctor	NOUN
gs-3960	4	6	of	of	ADP
gs-3960	4	7	pharmaceutical	pharmaceutical	NOUN
gs-3960	4	8	sciences	science	NOUN
gs-3960	4	9	,	,	PUNCT
gs-3960	4	10	academician	academician	NOUN
gs-3960	4	11	,	,	PUNCT
gs-3960	4	12	professor	professor	NOUN
gs-3960	4	13	of	of	ADP
gs-3960	4	14	yerevan	yerevan	PROPN
gs-3960	4	15	state	state	PROPN
gs-3960	4	16	medical	medical	PROPN
gs-3960	4	17	university	university	PROPN
gs-3960	4	18	after	after	ADP
gs-3960	4	19	mkhitar	mkhitar	NOUN
gs-3960	4	20	heratsi	heratsi	PROPN
gs-3960	4	21	,	,	PUNCT
gs-3960	4	22	head	head	NOUN
gs-3960	4	23	of	of	ADP
gs-3960	4	24	the	the	DET
gs-3960	4	25	department	department	PROPN
gs-3960	4	26	of	of	ADP
gs-3960	4	27	pharmaceutical	pharmaceutical	NOUN
gs-3960	4	28	management	management	NOUN
gs-3960	4	29	,	,	PUNCT
gs-3960	4	30	president	president	NOUN
gs-3960	4	31	of	of	ADP
gs-3960	4	32	association	association	PROPN
gs-3960	4	33	phesa	phesa	PROPN
gs-3960	4	34	(	(	PUNCT
gs-3960	4	35	pharmacy	pharmacy	NOUN
gs-3960	4	36	and	and	CCONJ
gs-3960	4	37	pharmacology	pharmacology	NOUN
gs-3960	4	38	education	education	NOUN
gs-3960	4	39	and	and	CCONJ
gs-3960	4	40	science	science	NOUN
gs-3960	4	41	association	association	PROPN
gs-3960	4	42	)	)	PUNCT
gs-3960	4	43	,	,	PUNCT
gs-3960	4	44	yerevan	yerevan	PROPN
gs-3960	4	45	,	,	PUNCT
gs-3960	4	46	armenia	armenia	PROPN
gs-3960	4	47	;	;	PUNCT
gs-3960	4	48	https://orcid.org/0000-0003-3697-6390	https://orcid.org/0000-0003-3697-6390	PROPN
gs-3960	4	49	4md	4md	NOUN
gs-3960	4	50	,	,	PUNCT
gs-3960	4	51	phd	phd	NOUN
gs-3960	4	52	,	,	PUNCT
gs-3960	4	53	doctor	doctor	NOUN
gs-3960	4	54	of	of	ADP
gs-3960	4	55	medical	medical	ADJ
gs-3960	4	56	sciences	sciences	PROPN
gs-3960	4	57	,	,	PUNCT
gs-3960	4	58	professor	professor	NOUN
gs-3960	4	59	,	,	PUNCT
gs-3960	4	60	director	director	NOUN
gs-3960	4	61	of	of	ADP
gs-3960	4	62	the	the	DET
gs-3960	4	63	scientific	scientific	ADJ
gs-3960	4	64	research	research	NOUN
gs-3960	4	65	-	-	PUNCT
gs-3960	4	66	skills	skill	NOUN
gs-3960	4	67	center	center	NOUN
gs-3960	4	68	at	at	ADP
gs-3960	4	69	tbilisi	tbilisi	PROPN
gs-3960	4	70	state	state	PROPN
gs-3960	4	71	medical	medical	PROPN
gs-3960	4	72	university	university	PROPN
gs-3960	4	73	,	,	PUNCT
gs-3960	4	74	professor	professor	NOUN
gs-3960	4	75	,	,	PUNCT
gs-3960	4	76	head	head	NOUN
gs-3960	4	77	of	of	ADP
gs-3960	4	78	the	the	DET
gs-3960	4	79	department	department	PROPN
gs-3960	4	80	of	of	ADP
gs-3960	4	81	medical	medical	ADJ
gs-3960	4	82	and	and	CCONJ
gs-3960	4	83	clinical	clinical	ADJ
gs-3960	4	84	pharmacology	pharmacology	NOUN
gs-3960	4	85	at	at	ADP
gs-3960	4	86	tbilisi	tbilisi	PROPN
gs-3960	4	87	state	state	PROPN
gs-3960	4	88	medical	medical	PROPN
gs-3960	4	89	university	university	PROPN
gs-3960	4	90	,	,	PUNCT
gs-3960	4	91	clinical	clinical	ADJ
gs-3960	4	92	pharmacologist	pharmacologist	NOUN
gs-3960	4	93	of	of	ADP
gs-3960	4	94	the	the	DET
gs-3960	4	95	first	first	ADJ
gs-3960	4	96	university	university	NOUN
gs-3960	4	97	clinic	clinic	NOUN
gs-3960	4	98	of	of	ADP
gs-3960	4	99	tsmu	tsmu	PROPN
gs-3960	4	100	,	,	PUNCT
gs-3960	4	101	tbilisi	tbilisi	PROPN
gs-3960	4	102	,	,	PUNCT
gs-3960	4	103	georgia	georgia	PROPN
gs-3960	4	104	https://orcid.org/0000-0003-0856-2684	https://orcid.org/0000-0003-0856-2684	PROPN
gs-3960	4	105	5md	5md	PROPN
gs-3960	4	106	,	,	PUNCT
gs-3960	4	107	phd	phd	NOUN
gs-3960	4	108	,	,	PUNCT
gs-3960	4	109	doctor	doctor	NOUN
gs-3960	4	110	of	of	ADP
gs-3960	4	111	pharmaceutical	pharmaceutical	NOUN
gs-3960	4	112	sciences	science	NOUN
gs-3960	4	113	,	,	PUNCT
gs-3960	4	114	academician	academician	NOUN
gs-3960	4	115	,	,	PUNCT
gs-3960	4	116	professor	professor	NOUN
gs-3960	4	117	of	of	ADP
gs-3960	4	118	tbilisi	tbilisi	PROPN
gs-3960	4	119	state	state	PROPN
gs-3960	4	120	medical	medical	PROPN
gs-3960	4	121	university	university	PROPN
gs-3960	4	122	,	,	PUNCT
gs-3960	4	123	head	head	NOUN
gs-3960	4	124	of	of	ADP
gs-3960	4	125	the	the	DET
gs-3960	4	126	department	department	NOUN
gs-3960	4	127	of	of	ADP
gs-3960	4	128	social	social	ADJ
gs-3960	4	129	and	and	CCONJ
gs-3960	4	130	clinical	clinical	ADJ
gs-3960	4	131	pharmacy	pharmacy	NOUN
gs-3960	4	132	,	,	PUNCT
gs-3960	4	133	tbilisi	tbilisi	PROPN
gs-3960	4	134	,	,	PUNCT
gs-3960	4	135	georgia	georgia	PROPN
gs-3960	4	136	.	.	PUNCT
gs-3960	5	1	https://orcid.org/0000-00024563-5224	https://orcid.org/0000-00024563-5224	PROPN
gs-3960	5	2	6md	6md	PROPN
gs-3960	5	3	,	,	PUNCT
gs-3960	5	4	phd	phd	NOUN
gs-3960	5	5	,	,	PUNCT
gs-3960	5	6	doctor	doctor	NOUN
gs-3960	5	7	of	of	ADP
gs-3960	5	8	pharmaceutical	pharmaceutical	NOUN
gs-3960	5	9	sciences	science	NOUN
gs-3960	5	10	,	,	PUNCT
gs-3960	5	11	professor	professor	NOUN
gs-3960	5	12	of	of	ADP
gs-3960	5	13	akaki	akaki	PROPN
gs-3960	5	14	tsereteli	tsereteli	PROPN
gs-3960	5	15	state	state	PROPN
gs-3960	5	16	university	university	PROPN
gs-3960	5	17	,	,	PUNCT
gs-3960	5	18	faculty	faculty	NOUN
gs-3960	5	19	of	of	ADP
gs-3960	5	20	medicine	medicine	NOUN
gs-3960	5	21	,	,	PUNCT
gs-3960	5	22	department	department	NOUN
gs-3960	5	23	of	of	ADP
gs-3960	5	24	pharmacy	pharmacy	NOUN
gs-3960	5	25	,	,	PUNCT
gs-3960	5	26	kutaisi	kutaisi	PROPN
gs-3960	5	27	,	,	PUNCT
gs-3960	5	28	georgia	georgia	PROPN
gs-3960	5	29	.	.	PUNCT
gs-3960	6	1	professor	professor	PROPN
gs-3960	6	2	,	,	PUNCT
gs-3960	6	3	dean	dean	PROPN
gs-3960	6	4	faculty	faculty	NOUN
gs-3960	6	5	of	of	ADP
gs-3960	6	6	medicine	medicine	NOUN
gs-3960	6	7	at	at	ADP
gs-3960	6	8	east	east	PROPN
gs-3960	6	9	european	european	PROPN
gs-3960	6	10	university	university	PROPN
gs-3960	6	11	,	,	PUNCT
gs-3960	6	12	tbilisi	tbilisi	PROPN
gs-3960	6	13	,	,	PUNCT
gs-3960	6	14	georgia	georgia	PROPN
gs-3960	6	15	.	.	PUNCT
gs-3960	7	1	https://orcid.org/0000-0001-6695-5924	https://orcid.org/0000-0001-6695-5924	PROPN
gs-3960	7	2	7md	7md	PROPN
gs-3960	7	3	,	,	PUNCT
gs-3960	7	4	phd	phd	NOUN
gs-3960	7	5	,	,	PUNCT
gs-3960	7	6	associate	associate	ADJ
gs-3960	7	7	professor	professor	NOUN
gs-3960	7	8	of	of	ADP
gs-3960	7	9	international	international	ADJ
gs-3960	7	10	school	school	NOUN
gs-3960	7	11	of	of	ADP
gs-3960	7	12	medicine	medicine	NOUN
gs-3960	7	13	at	at	ADP
gs-3960	7	14	alte	alte	PROPN
gs-3960	7	15	university	university	PROPN
gs-3960	7	16	;	;	PUNCT
gs-3960	7	17	tbilisi	tbilisi	PROPN
gs-3960	7	18	,	,	PUNCT
gs-3960	7	19	georgia	georgia	PROPN
gs-3960	7	20	8	8	NUM
gs-3960	7	21	new	new	PROPN
gs-3960	7	22	delhi	delhi	PROPN
gs-3960	7	23	india	india	PROPN
gs-3960	7	24	.	.	PUNCT
gs-3960	8	1	9laboratory	9laboratory	NUM
gs-3960	8	2	of	of	ADP
gs-3960	8	3	brain	brain	NOUN
gs-3960	8	4	ultrastructure	ultrastructure	NOUN
gs-3960	8	5	and	and	CCONJ
gs-3960	8	6	nanoarchitecture	nanoarchitecture	NOUN
gs-3960	8	7	,	,	PUNCT
gs-3960	8	8	ivane	ivane	NOUN
gs-3960	8	9	beritashvili	beritashvili	NOUN
gs-3960	8	10	center	center	PROPN
gs-3960	8	11	of	of	ADP
gs-3960	8	12	experimental	experimental	ADJ
gs-3960	8	13	biomedicine	biomedicine	NOUN
gs-3960	8	14	,	,	PUNCT
gs-3960	8	15	tbilisi	tbilisi	PROPN
gs-3960	8	16	,	,	PUNCT
gs-3960	8	17	georgia	georgia	PROPN
gs-3960	8	18	;	;	PUNCT
gs-3960	8	19	md	md	PROPN
gs-3960	8	20	student	student	NOUN
gs-3960	8	21	of	of	ADP
gs-3960	8	22	department	department	PROPN
gs-3960	8	23	of	of	ADP
gs-3960	8	24	medicine	medicine	NOUN
gs-3960	8	25	,	,	PUNCT
gs-3960	8	26	georgian	georgian	PROPN
gs-3960	8	27	national	national	PROPN
gs-3960	8	28	university	university	PROPN
gs-3960	8	29	seu	seu	PROPN
gs-3960	8	30	,	,	PUNCT
gs-3960	8	31	tbilisi	tbilisi	PROPN
gs-3960	8	32	,	,	PUNCT
gs-3960	8	33	georgia	georgia	PROPN
gs-3960	8	34	.	.	PUNCT
gs-3960	9	1	10md	10md	PROPN
gs-3960	9	2	,	,	PUNCT
gs-3960	9	3	phd	phd	NOUN
gs-3960	9	4	,	,	PUNCT
gs-3960	9	5	doctor	doctor	NOUN
gs-3960	9	6	of	of	ADP
gs-3960	9	7	medical	medical	ADJ
gs-3960	9	8	sciences	science	NOUN
gs-3960	9	9	,	,	PUNCT
gs-3960	9	10	invited	invite	VERB
gs-3960	9	11	professor	professor	NOUN
gs-3960	9	12	of	of	ADP
gs-3960	9	13	the	the	DET
gs-3960	9	14	scientific	scientific	ADJ
gs-3960	9	15	research	research	NOUN
gs-3960	9	16	skills	skill	NOUN
gs-3960	9	17	center	center	NOUN
gs-3960	9	18	of	of	ADP
gs-3960	9	19	tbilisi	tbilisi	PROPN
gs-3960	9	20	state	state	PROPN
gs-3960	9	21	medical	medical	PROPN
gs-3960	9	22	university	university	PROPN
gs-3960	9	23	,	,	PUNCT
gs-3960	9	24	professor	professor	NOUN
gs-3960	9	25	of	of	ADP
gs-3960	9	26	pathophysiology	pathophysiology	NOUN
gs-3960	9	27	department	department	NOUN
gs-3960	9	28	at	at	ADP
gs-3960	9	29	tbilisi	tbilisi	PROPN
gs-3960	9	30	state	state	PROPN
gs-3960	9	31	medical	medical	PROPN
gs-3960	9	32	university	university	PROPN
gs-3960	9	33	;	;	PUNCT
gs-3960	9	34	tbilisi	tbilisi	PROPN
gs-3960	9	35	,	,	PUNCT
gs-3960	9	36	georgia	georgia	PROPN
gs-3960	9	37	.	.	PUNCT
gs-3960	10	1	https://orcid.org/0000-0002-3845-9306	https://orcid.org/0000-0002-3845-9306	PROPN
gs-3960	10	2	georgian	georgian	NOUN
gs-3960	10	3	scientists/	scientists/	NUM
gs-3960	10	4	.	.	PUNCT
gs-3960	11	1	7	7	NUM
gs-3960	11	2	n	n	PRON
gs-3960	11	3	3	3	NUM
gs-3960	11	4	,	,	PUNCT
gs-3960	11	5	2025	2025	NUM
gs-3960	11	6	398	398	NUM
gs-3960	11	7	11md	11md	NOUN
gs-3960	11	8	,	,	PUNCT
gs-3960	11	9	doctor	doctor	NOUN
gs-3960	11	10	of	of	ADP
gs-3960	11	11	family	family	NOUN
gs-3960	11	12	medicine	medicine	NOUN
gs-3960	11	13	,	,	PUNCT
gs-3960	11	14	invited	invite	VERB
gs-3960	11	15	lecturer	lecturer	NOUN
gs-3960	11	16	of	of	ADP
gs-3960	11	17	tbilisi	tbilisi	PROPN
gs-3960	11	18	state	state	PROPN
gs-3960	11	19	medical	medical	PROPN
gs-3960	11	20	university	university	PROPN
gs-3960	11	21	,	,	PUNCT
gs-3960	11	22	department	department	NOUN
gs-3960	11	23	of	of	ADP
gs-3960	11	24	molecular	molecular	ADJ
gs-3960	11	25	and	and	CCONJ
gs-3960	11	26	medical	medical	ADJ
gs-3960	11	27	genetics	genetic	NOUN
gs-3960	11	28	,	,	PUNCT
gs-3960	11	29	invited	invite	VERB
gs-3960	11	30	professor	professor	NOUN
gs-3960	11	31	of	of	ADP
gs-3960	11	32	biochemistry	biochemistry	NOUN
gs-3960	11	33	and	and	CCONJ
gs-3960	11	34	molecular	molecular	ADJ
gs-3960	11	35	and	and	CCONJ
gs-3960	11	36	medical	medical	ADJ
gs-3960	11	37	genetics	genetic	NOUN
gs-3960	11	38	at	at	ADP
gs-3960	11	39	the	the	DET
gs-3960	11	40	university	university	PROPN
gs-3960	11	41	of	of	ADP
gs-3960	11	42	georgia	georgia	PROPN
gs-3960	11	43	;	;	PUNCT
gs-3960	11	44	tbilisi	tbilisi	PROPN
gs-3960	11	45	,	,	PUNCT
gs-3960	11	46	georgia	georgia	PROPN
gs-3960	11	47	.	.	PUNCT
gs-3960	12	1	12md	12md	ADJ
gs-3960	12	2	,	,	PUNCT
gs-3960	12	3	phd	phd	NOUN
gs-3960	12	4	,	,	PUNCT
gs-3960	12	5	doctor	doctor	NOUN
gs-3960	12	6	of	of	ADP
gs-3960	12	7	medical	medical	ADJ
gs-3960	12	8	sciences	science	NOUN
gs-3960	12	9	,	,	PUNCT
gs-3960	12	10	professor	professor	NOUN
gs-3960	12	11	of	of	ADP
gs-3960	12	12	faculty	faculty	NOUN
gs-3960	12	13	of	of	ADP
gs-3960	12	14	medicine	medicine	NOUN
gs-3960	12	15	at	at	ADP
gs-3960	12	16	caucasus	caucasus	PROPN
gs-3960	12	17	international	international	PROPN
gs-3960	12	18	university	university	PROPN
gs-3960	12	19	;	;	PUNCT
gs-3960	12	20	tbilisi	tbilisi	PROPN
gs-3960	12	21	,	,	PUNCT
gs-3960	12	22	georgia	georgia	PROPN
gs-3960	12	23	;	;	PUNCT
gs-3960	12	24	13md	13md	NOUN
gs-3960	12	25	,	,	PUNCT
gs-3960	12	26	phd	phd	NOUN
gs-3960	12	27	,	,	PUNCT
gs-3960	12	28	doctor	doctor	NOUN
gs-3960	12	29	of	of	ADP
gs-3960	12	30	medical	medical	ADJ
gs-3960	12	31	sciences	science	NOUN
gs-3960	12	32	,	,	PUNCT
gs-3960	12	33	academician	academician	NOUN
gs-3960	12	34	,	,	PUNCT
gs-3960	12	35	professor	professor	NOUN
gs-3960	12	36	of	of	ADP
gs-3960	12	37	faculty	faculty	NOUN
gs-3960	12	38	of	of	ADP
gs-3960	12	39	medicine	medicine	NOUN
gs-3960	12	40	at	at	ADP
gs-3960	12	41	caucasus	caucasus	PROPN
gs-3960	12	42	international	international	PROPN
gs-3960	12	43	university	university	PROPN
gs-3960	12	44	;	;	PUNCT
gs-3960	12	45	doctor	doctor	NOUN
gs-3960	12	46	-	-	PUNCT
gs-3960	12	47	professor	professor	NOUN
gs-3960	12	48	of	of	ADP
gs-3960	12	49	national	national	PROPN
gs-3960	12	50	health	health	PROPN
gs-3960	12	51	center	center	NOUN
gs-3960	12	52	named	name	VERB
gs-3960	12	53	after	after	ADP
gs-3960	12	54	academician	academician	PROPN
gs-3960	12	55	o.	o.	PROPN
gs-3960	12	56	gudushauri	gudushauri	PROPN
gs-3960	12	57	;	;	PUNCT
gs-3960	12	58	tbilisi	tbilisi	PROPN
gs-3960	12	59	,	,	PUNCT
gs-3960	12	60	georgia	georgia	PROPN
gs-3960	12	61	;	;	PUNCT
gs-3960	12	62	14md	14md	NUM
gs-3960	12	63	,	,	PUNCT
gs-3960	12	64	phd	phd	NOUN
gs-3960	12	65	,	,	PUNCT
gs-3960	12	66	doctor	doctor	NOUN
gs-3960	12	67	of	of	ADP
gs-3960	12	68	medical	medical	ADJ
gs-3960	12	69	sciences	science	NOUN
gs-3960	12	70	,	,	PUNCT
gs-3960	12	71	professor	professor	NOUN
gs-3960	12	72	of	of	ADP
gs-3960	12	73	tbilisi	tbilisi	PROPN
gs-3960	12	74	state	state	PROPN
gs-3960	12	75	medical	medical	PROPN
gs-3960	12	76	university	university	PROPN
gs-3960	12	77	,	,	PUNCT
gs-3960	12	78	department	department	NOUN
gs-3960	12	79	of	of	ADP
gs-3960	12	80	public	public	ADJ
gs-3960	12	81	health	health	NOUN
gs-3960	12	82	,	,	PUNCT
gs-3960	12	83	health	health	NOUN
gs-3960	12	84	care	care	NOUN
gs-3960	12	85	management	management	NOUN
gs-3960	12	86	,	,	PUNCT
gs-3960	12	87	policy	policy	NOUN
gs-3960	12	88	and	and	CCONJ
gs-3960	12	89	economy	economy	NOUN
gs-3960	12	90	,	,	PUNCT
gs-3960	12	91	tbilisi	tbilisi	PROPN
gs-3960	12	92	,	,	PUNCT
gs-3960	12	93	georgia	georgia	PROPN
gs-3960	12	94	.	.	PUNCT
gs-3960	13	1	15md	15md	ADJ
gs-3960	13	2	,	,	PUNCT
gs-3960	13	3	phd	phd	NOUN
gs-3960	13	4	,	,	PUNCT
gs-3960	13	5	doctor	doctor	NOUN
gs-3960	13	6	of	of	ADP
gs-3960	13	7	medical	medical	ADJ
gs-3960	13	8	sciences	science	NOUN
gs-3960	13	9	,	,	PUNCT
gs-3960	13	10	academician	academician	NOUN
gs-3960	13	11	,	,	PUNCT
gs-3960	13	12	professor	professor	NOUN
gs-3960	13	13	of	of	ADP
gs-3960	13	14	tbilisi	tbilisi	PROPN
gs-3960	13	15	state	state	PROPN
gs-3960	13	16	medical	medical	PROPN
gs-3960	13	17	university	university	PROPN
gs-3960	13	18	,	,	PUNCT
gs-3960	13	19	dean	dean	NOUN
gs-3960	13	20	of	of	ADP
gs-3960	13	21	the	the	DET
gs-3960	13	22	faculty	faculty	NOUN
gs-3960	13	23	of	of	ADP
gs-3960	13	24	public	public	ADJ
gs-3960	13	25	health	health	NOUN
gs-3960	13	26	,	,	PUNCT
gs-3960	13	27	head	head	NOUN
gs-3960	13	28	of	of	ADP
gs-3960	13	29	the	the	DET
gs-3960	13	30	department	department	NOUN
gs-3960	13	31	of	of	ADP
gs-3960	13	32	nutrition	nutrition	NOUN
gs-3960	13	33	,	,	PUNCT
gs-3960	13	34	aging	age	VERB
gs-3960	13	35	medicine	medicine	NOUN
gs-3960	13	36	,	,	PUNCT
gs-3960	13	37	environmental	environmental	ADJ
gs-3960	13	38	and	and	CCONJ
gs-3960	13	39	occupational	occupational	ADJ
gs-3960	13	40	health	health	NOUN
gs-3960	13	41	,	,	PUNCT
gs-3960	13	42	tbilisi	tbilisi	PROPN
gs-3960	13	43	,	,	PUNCT
gs-3960	13	44	georgia	georgia	PROPN
gs-3960	13	45	.	.	PUNCT
gs-3960	13	46	16phd	16phd	PROPN
gs-3960	13	47	,	,	PUNCT
gs-3960	13	48	doctor	doctor	NOUN
gs-3960	13	49	of	of	ADP
gs-3960	13	50	biological	biological	ADJ
gs-3960	13	51	sciences	science	NOUN
gs-3960	13	52	,	,	PUNCT
gs-3960	13	53	professor	professor	NOUN
gs-3960	13	54	of	of	ADP
gs-3960	13	55	international	international	ADJ
gs-3960	13	56	school	school	NOUN
gs-3960	13	57	of	of	ADP
gs-3960	13	58	medicine	medicine	NOUN
gs-3960	13	59	at	at	ADP
gs-3960	13	60	alte	alte	PROPN
gs-3960	13	61	university	university	PROPN
gs-3960	13	62	,	,	PUNCT
gs-3960	13	63	tbilisi	tbilisi	PROPN
gs-3960	13	64	,	,	PUNCT
gs-3960	13	65	georgia	georgia	PROPN
gs-3960	13	66	;	;	PUNCT
gs-3960	13	67	corresponding	correspond	VERB
gs-3960	13	68	author	author	NOUN
gs-3960	13	69	:	:	PUNCT
gs-3960	13	70	dr	dr	PROPN
gs-3960	13	71	.	.	PROPN
gs-3960	13	72	professor	professor	PROPN
gs-3960	13	73	nodar	nodar	PROPN
gs-3960	13	74	sulashvili	sulashvili	PROPN
gs-3960	13	75	mail	mail	NOUN
gs-3960	13	76	:	:	PUNCT
gs-3960	13	77	n.sulashvili@ug.edu.ge	n.sulashvili@ug.edu.ge	NOUN
gs-3960	13	78	mob	mob	NOUN
gs-3960	13	79	:	:	PUNCT
gs-3960	13	80	+995	+995	ADJ
gs-3960	13	81	-	-	ADJ
gs-3960	13	82	597	597	NUM
gs-3960	13	83	-	-	PUNCT
gs-3960	13	84	12	12	NUM
gs-3960	13	85	-	-	PUNCT
gs-3960	13	86	17	17	NUM
gs-3960	13	87	-	-	SYM
gs-3960	13	88	28	28	NUM
gs-3960	13	89	abstract	abstract	ADJ
gs-3960	13	90	parkinson	parkinson	NOUN
gs-3960	13	91	's	's	PART
gs-3960	13	92	disease	disease	NOUN
gs-3960	13	93	(	(	PUNCT
gs-3960	13	94	pd	pd	NOUN
gs-3960	13	95	)	)	PUNCT
gs-3960	13	96	is	be	AUX
gs-3960	13	97	a	a	DET
gs-3960	13	98	prevalent	prevalent	ADJ
gs-3960	13	99	neurodegenerative	neurodegenerative	ADJ
gs-3960	13	100	disorder	disorder	NOUN
gs-3960	13	101	characterized	characterize	VERB
gs-3960	13	102	by	by	ADP
gs-3960	13	103	the	the	DET
gs-3960	13	104	progressive	progressive	ADJ
gs-3960	13	105	loss	loss	NOUN
gs-3960	13	106	of	of	ADP
gs-3960	13	107	dopaminergic	dopaminergic	ADJ
gs-3960	13	108	neurons	neuron	NOUN
gs-3960	13	109	and	and	CCONJ
gs-3960	13	110	the	the	DET
gs-3960	13	111	accumulation	accumulation	NOUN
gs-3960	13	112	of	of	ADP
gs-3960	13	113	-synuclein	-synuclein	PROPN
gs-3960	13	114	in	in	ADP
gs-3960	13	115	lewy	lewy	ADJ
gs-3960	13	116	bodies	body	NOUN
gs-3960	13	117	.	.	PUNCT
gs-3960	14	1	mitochondrial	mitochondrial	ADJ
gs-3960	14	2	dysfunction	dysfunction	NOUN
gs-3960	14	3	plays	play	VERB
gs-3960	14	4	a	a	DET
gs-3960	14	5	central	central	ADJ
gs-3960	14	6	role	role	NOUN
gs-3960	14	7	in	in	ADP
gs-3960	14	8	both	both	CCONJ
gs-3960	14	9	sporadic	sporadic	ADJ
gs-3960	14	10	and	and	CCONJ
gs-3960	14	11	familial	familial	ADJ
gs-3960	14	12	pd	pd	NOUN
gs-3960	14	13	,	,	PUNCT
gs-3960	14	14	contributing	contribute	VERB
gs-3960	14	15	to	to	ADP
gs-3960	14	16	bioenergetic	bioenergetic	ADJ
gs-3960	14	17	deficits	deficit	NOUN
gs-3960	14	18	,	,	PUNCT
gs-3960	14	19	oxidative	oxidative	ADJ
gs-3960	14	20	stress	stress	NOUN
gs-3960	14	21	,	,	PUNCT
gs-3960	14	22	and	and	CCONJ
gs-3960	14	23	mitochondrial	mitochondrial	ADJ
gs-3960	14	24	dna	dna	NOUN
gs-3960	14	25	(	(	PUNCT
gs-3960	14	26	mtdna	mtdna	NOUN
gs-3960	14	27	)	)	PUNCT
gs-3960	14	28	strategies	strategy	NOUN
gs-3960	14	29	aimed	aim	VERB
gs-3960	14	30	at	at	ADP
gs-3960	14	31	restoring	restore	VERB
gs-3960	14	32	mitochondrial	mitochondrial	ADJ
gs-3960	14	33	function	function	NOUN
gs-3960	14	34	.	.	PUNCT
gs-3960	15	1	additionally	additionally	ADV
gs-3960	15	2	,	,	PUNCT
gs-3960	15	3	we	we	PRON
gs-3960	15	4	discuss	discuss	VERB
gs-3960	15	5	the	the	DET
gs-3960	15	6	significance	significance	NOUN
gs-3960	15	7	of	of	ADP
gs-3960	15	8	nicotinamide	nicotinamide	NOUN
gs-3960	15	9	adenine	adenine	ADJ
gs-3960	15	10	dinucleotide	dinucleotide	NOUN
gs-3960	15	11	(	(	PUNCT
gs-3960	15	12	nad+	nad+	NOUN
gs-3960	15	13	)	)	PUNCT
gs-3960	15	14	metabolism	metabolism	NOUN
gs-3960	15	15	in	in	ADP
gs-3960	15	16	mitigating	mitigate	VERB
gs-3960	15	17	mitochondrial	mitochondrial	ADJ
gs-3960	15	18	dysfunction	dysfunction	NOUN
gs-3960	15	19	and	and	CCONJ
gs-3960	15	20	its	its	PRON
gs-3960	15	21	implications	implication	NOUN
gs-3960	15	22	for	for	ADP
gs-3960	15	23	pd	pd	NOUN
gs-3960	15	24	pathogenesis	pathogenesis	NOUN
gs-3960	15	25	.	.	PUNCT
gs-3960	16	1	emerging	emerge	VERB
gs-3960	16	2	pharmacological	pharmacological	ADJ
gs-3960	16	3	interventions	intervention	NOUN
gs-3960	16	4	targeting	target	VERB
gs-3960	16	5	mitophagy	mitophagy	NOUN
gs-3960	16	6	and	and	CCONJ
gs-3960	16	7	nad+	nad+	PROPN
gs-3960	16	8	metabolism	metabolism	NOUN
gs-3960	16	9	are	be	AUX
gs-3960	16	10	proposed	propose	VERB
gs-3960	16	11	as	as	ADP
gs-3960	16	12	promising	promise	VERB
gs-3960	16	13	therapeutic	therapeutic	ADJ
gs-3960	16	14	avenues	avenue	NOUN
gs-3960	16	15	to	to	PART
gs-3960	16	16	slow	slow	VERB
gs-3960	16	17	or	or	CCONJ
gs-3960	16	18	halt	halt	VERB
gs-3960	16	19	neurodegeneration	neurodegeneration	NOUN
gs-3960	16	20	in	in	ADP
gs-3960	16	21	pd	pd	PROPN
gs-3960	16	22	.	.	PROPN
gs-3960	16	23	mitochondrial	mitochondrial	ADJ
gs-3960	16	24	contributing	contribute	VERB
gs-3960	16	25	to	to	ADP
gs-3960	16	26	neuronal	neuronal	ADJ
gs-3960	16	27	degeneration	degeneration	NOUN
gs-3960	16	28	through	through	ADP
gs-3960	16	29	oxidative	oxidative	ADJ
gs-3960	16	30	stress	stress	NOUN
gs-3960	16	31	,	,	PUNCT
gs-3960	16	32	bioenergetic	bioenergetic	ADJ
gs-3960	16	33	failure	failure	NOUN
gs-3960	16	34	,	,	PUNCT
gs-3960	16	35	and	and	CCONJ
gs-3960	16	36	impaired	impaired	ADJ
gs-3960	16	37	quality	quality	NOUN
gs-3960	16	38	control	control	NOUN
gs-3960	16	39	mechanisms	mechanism	NOUN
gs-3960	16	40	.	.	PUNCT
gs-3960	17	1	this	this	DET
gs-3960	17	2	review	review	NOUN
gs-3960	17	3	critically	critically	ADV
gs-3960	17	4	examines	examine	VERB
gs-3960	17	5	key	key	ADJ
gs-3960	17	6	aspects	aspect	NOUN
gs-3960	17	7	of	of	ADP
gs-3960	17	8	mitochondrial	mitochondrial	ADJ
gs-3960	17	9	dysfunction	dysfunction	NOUN
gs-3960	17	10	in	in	ADP
gs-3960	17	11	pd	pd	PROPN
gs-3960	17	12	,	,	PUNCT
gs-3960	17	13	with	with	ADP
gs-3960	17	14	a	a	DET
gs-3960	17	15	focus	focus	NOUN
gs-3960	17	16	on	on	ADP
gs-3960	17	17	mitophagy	mitophagy	NOUN
gs-3960	17	18	and	and	CCONJ
gs-3960	17	19	nad+	nad+	PROPN
gs-3960	17	20	metabolism	metabolism	NOUN
gs-3960	17	21	as	as	ADP
gs-3960	17	22	pivotal	pivotal	ADJ
gs-3960	17	23	therapeutic	therapeutic	ADJ
gs-3960	17	24	targets	target	NOUN
gs-3960	17	25	.	.	PUNCT
gs-3960	18	1	dysregulated	dysregulated	ADJ
gs-3960	18	2	mitophagy	mitophagy	NOUN
gs-3960	18	3	,	,	PUNCT
gs-3960	18	4	particularly	particularly	ADV
gs-3960	18	5	involving	involve	VERB
gs-3960	18	6	pink1	pink1	NOUN
gs-3960	18	7	-	-	PUNCT
gs-3960	18	8	parkin	parkin	NOUN
gs-3960	18	9	signaling	signaling	NOUN
gs-3960	18	10	,	,	PUNCT
gs-3960	18	11	leads	lead	VERB
gs-3960	18	12	to	to	ADP
gs-3960	18	13	the	the	DET
gs-3960	18	14	accumulation	accumulation	NOUN
gs-3960	18	15	of	of	ADP
gs-3960	18	16	damaged	damage	VERB
gs-3960	18	17	mitochondria	mitochondria	NOUN
gs-3960	18	18	,	,	PUNCT
gs-3960	18	19	exacerbating	exacerbate	VERB
gs-3960	18	20	neurodegeneration	neurodegeneration	NOUN
gs-3960	18	21	.	.	PUNCT
gs-3960	19	1	additionally	additionally	ADV
gs-3960	19	2	,	,	PUNCT
gs-3960	19	3	declining	decline	VERB
gs-3960	19	4	nad+	nad+	PROPN
gs-3960	19	5	levels	level	NOUN
gs-3960	19	6	impair	impair	VERB
gs-3960	19	7	mitochondrial	mitochondrial	ADJ
gs-3960	19	8	bioenergetics	bioenergetic	NOUN
gs-3960	19	9	and	and	CCONJ
gs-3960	19	10	cellular	cellular	ADJ
gs-3960	19	11	resilience	resilience	NOUN
gs-3960	19	12	,	,	PUNCT
gs-3960	19	13	further	far	ADV
gs-3960	19	14	aggravating	aggravate	VERB
gs-3960	19	15	pd	pd	NOUN
gs-3960	19	16	progression	progression	NOUN
gs-3960	19	17	.	.	PUNCT
gs-3960	20	1	emerging	emerge	VERB
gs-3960	20	2	therapeutic	therapeutic	ADJ
gs-3960	20	3	strategies	strategy	NOUN
gs-3960	20	4	,	,	PUNCT
gs-3960	20	5	including	include	VERB
gs-3960	20	6	nad+	nad+	PROPN
gs-3960	20	7	supplementation	supplementation	NOUN
gs-3960	20	8	,	,	PUNCT
gs-3960	20	9	mitophagy	mitophagy	NOUN
gs-3960	20	10	enhancers	enhancer	NOUN
gs-3960	20	11	,	,	PUNCT
gs-3960	20	12	and	and	CCONJ
gs-3960	20	13	metabolic	metabolic	NOUN
gs-3960	20	14	modulators	modulator	NOUN
gs-3960	20	15	,	,	PUNCT
gs-3960	20	16	hold	hold	VERB
gs-3960	20	17	promise	promise	NOUN
gs-3960	20	18	for	for	ADP
gs-3960	20	19	restoring	restore	VERB
gs-3960	20	20	mitochondrial	mitochondrial	ADJ
gs-3960	20	21	homeostasis	homeostasis	NOUN
gs-3960	20	22	and	and	CCONJ
gs-3960	20	23	georgian	georgian	NOUN
gs-3960	20	24	scientists/	scientists/	NUM
gs-3960	20	25	.	.	PUNCT
gs-3960	21	1	7	7	NUM
gs-3960	21	2	n	n	PRON
gs-3960	21	3	3	3	NUM
gs-3960	21	4	,	,	PUNCT
gs-3960	21	5	2025	2025	NUM
gs-3960	21	6	399	399	NUM
gs-3960	21	7	neuroprotection	neuroprotection	NOUN
gs-3960	21	8	.	.	PUNCT
gs-3960	22	1	by	by	ADP
gs-3960	22	2	integrating	integrate	VERB
gs-3960	22	3	current	current	ADJ
gs-3960	22	4	research	research	NOUN
gs-3960	22	5	,	,	PUNCT
gs-3960	22	6	this	this	DET
gs-3960	22	7	discussion	discussion	NOUN
gs-3960	22	8	highlights	highlight	VERB
gs-3960	22	9	the	the	DET
gs-3960	22	10	potential	potential	NOUN
gs-3960	22	11	of	of	ADP
gs-3960	22	12	targeting	target	VERB
gs-3960	22	13	mitochondrial	mitochondrial	ADJ
gs-3960	22	14	pathways	pathway	NOUN
gs-3960	22	15	to	to	PART
gs-3960	22	16	develop	develop	VERB
gs-3960	22	17	novel	novel	ADJ
gs-3960	22	18	interventions	intervention	NOUN
gs-3960	22	19	for	for	ADP
gs-3960	22	20	pd	pd	NOUN
gs-3960	22	21	,	,	PUNCT
gs-3960	22	22	while	while	SCONJ
gs-3960	22	23	addressing	address	VERB
gs-3960	22	24	remaining	remain	VERB
gs-3960	22	25	challenges	challenge	NOUN
gs-3960	22	26	in	in	ADP
gs-3960	22	27	translational	translational	ADJ
gs-3960	22	28	application	application	NOUN
gs-3960	22	29	.	.	PUNCT
gs-3960	23	1	keywords	keyword	NOUN
gs-3960	23	2	:	:	PUNCT
gs-3960	23	3	mitochondrial	mitochondrial	ADJ
gs-3960	23	4	medicine	medicine	NOUN
gs-3960	23	5	.	.	PUNCT
gs-3960	24	1	introduction	introduction	NOUN
gs-3960	24	2	millions	million	NOUN
gs-3960	24	3	worldwide	worldwide	ADV
gs-3960	24	4	,	,	PUNCT
gs-3960	24	5	characterized	characterize	VERB
gs-3960	24	6	by	by	ADP
gs-3960	24	7	the	the	DET
gs-3960	24	8	degeneration	degeneration	NOUN
gs-3960	24	9	of	of	ADP
gs-3960	24	10	dopaminergic	dopaminergic	ADJ
gs-3960	24	11	neurons	neuron	NOUN
gs-3960	24	12	in	in	ADP
gs-3960	24	13	the	the	DET
gs-3960	24	14	substantia	substantia	NOUN
gs-3960	24	15	nigra	nigra	NOUN
gs-3960	24	16	and	and	CCONJ
gs-3960	24	17	the	the	DET
gs-3960	24	18	accumulation	accumulation	NOUN
gs-3960	24	19	of	of	ADP
gs-3960	24	20	lewy	lewy	PROPN
gs-3960	24	21	bodies	body	NOUN
gs-3960	24	22	composed	compose	VERB
gs-3960	24	23	of	of	ADP
gs-3960	24	24	-synuclein	-synuclein	PROPN
gs-3960	24	25	.	.	PUNCT
gs-3960	25	1	while	while	SCONJ
gs-3960	25	2	its	its	PRON
gs-3960	25	3	precise	precise	ADJ
gs-3960	25	4	etiology	etiology	NOUN
gs-3960	25	5	remains	remain	VERB
gs-3960	25	6	unclear	unclear	ADJ
gs-3960	25	7	,	,	PUNCT
gs-3960	25	8	mitochondrial	mitochondrial	ADJ
gs-3960	25	9	dysfunction	dysfunction	NOUN
gs-3960	25	10	is	be	AUX
gs-3960	25	11	increasingly	increasingly	ADV
gs-3960	25	12	recognized	recognize	VERB
gs-3960	25	13	as	as	ADP
gs-3960	25	14	a	a	DET
gs-3960	25	15	central	central	ADJ
gs-3960	25	16	contributor	contributor	NOUN
gs-3960	25	17	to	to	ADP
gs-3960	25	18	pd	pd	PROPN
gs-3960	25	19	pathogenesis	pathogenesis	PROPN
gs-3960	25	20	.	.	PUNCT
gs-3960	26	1	given	give	VERB
gs-3960	26	2	the	the	DET
gs-3960	26	3	high	high	ADJ
gs-3960	26	4	energy	energy	NOUN
gs-3960	26	5	demands	demand	NOUN
gs-3960	26	6	of	of	ADP
gs-3960	26	7	neurons	neuron	NOUN
gs-3960	26	8	,	,	PUNCT
gs-3960	26	9	mitochondria	mitochondria	PROPN
gs-3960	26	10	play	play	VERB
gs-3960	26	11	a	a	DET
gs-3960	26	12	crucial	crucial	ADJ
gs-3960	26	13	role	role	NOUN
gs-3960	26	14	in	in	ADP
gs-3960	26	15	maintaining	maintain	VERB
gs-3960	26	16	neuronal	neuronal	ADJ
gs-3960	26	17	health	health	NOUN
gs-3960	26	18	.	.	PUNCT
gs-3960	27	1	however	however	ADV
gs-3960	27	2	,	,	PUNCT
gs-3960	27	3	in	in	ADP
gs-3960	27	4	pd	pd	PROPN
gs-3960	27	5	,	,	PUNCT
gs-3960	27	6	mitochondrial	mitochondrial	ADJ
gs-3960	27	7	impairments	impairment	NOUN
gs-3960	27	8	lead	lead	VERB
gs-3960	27	9	to	to	PART
gs-3960	27	10	disrupted	disrupt	VERB
gs-3960	27	11	cellular	cellular	ADJ
gs-3960	27	12	respiration	respiration	NOUN
gs-3960	27	13	,	,	PUNCT
gs-3960	27	14	oxidative	oxidative	ADJ
gs-3960	27	15	stress	stress	NOUN
gs-3960	27	16	,	,	PUNCT
gs-3960	27	17	and	and	CCONJ
gs-3960	27	18	neuronal	neuronal	ADJ
gs-3960	27	19	loss	loss	NOUN
gs-3960	27	20	[	[	X
gs-3960	27	21	1	1	NUM
gs-3960	27	22	-	-	SYM
gs-3960	27	23	4	4	NUM
gs-3960	27	24	]	]	PUNCT
gs-3960	27	25	.	.	PUNCT
gs-3960	28	1	a	a	DET
gs-3960	28	2	key	key	ADJ
gs-3960	28	3	quality	quality	NOUN
gs-3960	28	4	control	control	NOUN
gs-3960	28	5	mechanism	mechanism	NOUN
gs-3960	28	6	involved	involve	VERB
gs-3960	28	7	in	in	ADP
gs-3960	28	8	preserving	preserve	VERB
gs-3960	28	9	mitochondrial	mitochondrial	ADJ
gs-3960	28	10	function	function	NOUN
gs-3960	28	11	is	be	AUX
gs-3960	28	12	mitophagy	mitophagy	ADJ
gs-3960	28	13	have	have	AUX
gs-3960	28	14	been	be	AUX
gs-3960	28	15	linked	link	VERB
gs-3960	28	16	to	to	ADP
gs-3960	28	17	pd	pd	PROPN
gs-3960	28	18	,	,	PUNCT
gs-3960	28	19	exacerbating	exacerbate	VERB
gs-3960	28	20	mitochondrial	mitochondrial	ADJ
gs-3960	28	21	dysfunction	dysfunction	NOUN
gs-3960	28	22	and	and	CCONJ
gs-3960	28	23	driving	drive	VERB
gs-3960	28	24	neurodegeneration	neurodegeneration	NOUN
gs-3960	28	25	.	.	PUNCT
gs-3960	29	1	additionally	additionally	ADV
gs-3960	29	2	,	,	PUNCT
gs-3960	29	3	alterations	alteration	NOUN
gs-3960	29	4	in	in	ADP
gs-3960	29	5	nad+	nad+	PROPN
gs-3960	29	6	metabolism	metabolism	NOUN
gs-3960	29	7	,	,	PUNCT
gs-3960	29	8	which	which	PRON
gs-3960	29	9	is	be	AUX
gs-3960	29	10	essential	essential	ADJ
gs-3960	29	11	for	for	ADP
gs-3960	29	12	mitochondrial	mitochondrial	ADJ
gs-3960	29	13	homeostasis	homeostasis	NOUN
gs-3960	29	14	,	,	PUNCT
gs-3960	29	15	further	far	ADV
gs-3960	29	16	worsen	worsen	VERB
gs-3960	29	17	mitochondrial	mitochondrial	ADJ
gs-3960	29	18	impairments	impairment	NOUN
gs-3960	29	19	in	in	ADP
gs-3960	29	20	pd	pd	PROPN
gs-3960	30	1	[	[	X
gs-3960	30	2	5	5	NUM
gs-3960	30	3	-	-	SYM
gs-3960	30	4	7	7	NUM
gs-3960	30	5	]	]	PUNCT
gs-3960	30	6	.	.	PUNCT
gs-3960	31	1	parkinson	parkinson	NOUN
gs-3960	31	2	's	's	PART
gs-3960	31	3	disease	disease	NOUN
gs-3960	31	4	(	(	PUNCT
gs-3960	31	5	pd	pd	NOUN
gs-3960	31	6	)	)	PUNCT
gs-3960	31	7	is	be	AUX
gs-3960	31	8	a	a	DET
gs-3960	31	9	progressive	progressive	ADJ
gs-3960	31	10	neurodegenerative	neurodegenerative	ADJ
gs-3960	31	11	disorder	disorder	NOUN
gs-3960	31	12	primarily	primarily	ADV
gs-3960	31	13	affecting	affect	VERB
gs-3960	31	14	the	the	DET
gs-3960	31	15	motor	motor	NOUN
gs-3960	31	16	system	system	NOUN
gs-3960	31	17	,	,	PUNCT
gs-3960	31	18	characterized	characterize	VERB
gs-3960	31	19	by	by	ADP
gs-3960	31	20	the	the	DET
gs-3960	31	21	selective	selective	ADJ
gs-3960	31	22	loss	loss	NOUN
gs-3960	31	23	of	of	ADP
gs-3960	31	24	dopaminergic	dopaminergic	ADJ
gs-3960	31	25	neurons	neuron	NOUN
gs-3960	31	26	in	in	ADP
gs-3960	31	27	the	the	DET
gs-3960	31	28	substantia	substantia	NOUN
gs-3960	31	29	nigra	nigra	PROPN
gs-3960	31	30	pars	par	NOUN
gs-3960	31	31	compacta	compacta	NOUN
gs-3960	31	32	and	and	CCONJ
gs-3960	31	33	the	the	DET
gs-3960	31	34	accumulation	accumulation	NOUN
gs-3960	31	35	of	of	ADP
gs-3960	31	36	lewy	lewy	PROPN
gs-3960	31	37	bodies	body	NOUN
gs-3960	31	38	composed	compose	VERB
gs-3960	31	39	mainly	mainly	ADV
gs-3960	31	40	of	of	ADP
gs-3960	31	41	-synuclein	-synuclein	PROPN
gs-3960	31	42	.	.	PUNCT
gs-3960	32	1	despite	despite	SCONJ
gs-3960	32	2	extensive	extensive	ADJ
gs-3960	32	3	research	research	NOUN
gs-3960	32	4	,	,	PUNCT
gs-3960	32	5	the	the	DET
gs-3960	32	6	exact	exact	ADJ
gs-3960	32	7	etiology	etiology	NOUN
gs-3960	32	8	of	of	ADP
gs-3960	32	9	pd	pd	PROPN
gs-3960	32	10	remains	remain	VERB
gs-3960	32	11	elusive	elusive	ADJ
gs-3960	32	12	.	.	PUNCT
gs-3960	33	1	however	however	ADV
gs-3960	33	2	,	,	PUNCT
gs-3960	33	3	accumulating	accumulate	VERB
gs-3960	33	4	evidence	evidence	NOUN
gs-3960	33	5	has	have	AUX
gs-3960	33	6	underscored	underscore	VERB
gs-3960	33	7	mitochondrial	mitochondrial	ADJ
gs-3960	33	8	dysfunction	dysfunction	NOUN
gs-3960	33	9	as	as	ADP
gs-3960	33	10	a	a	DET
gs-3960	33	11	central	central	ADJ
gs-3960	33	12	pathological	pathological	ADJ
gs-3960	33	13	mechanism	mechanism	NOUN
gs-3960	33	14	in	in	ADP
gs-3960	33	15	both	both	CCONJ
gs-3960	33	16	familial	familial	ADJ
gs-3960	33	17	and	and	CCONJ
gs-3960	33	18	sporadic	sporadic	ADJ
gs-3960	33	19	forms	form	NOUN
gs-3960	33	20	of	of	ADP
gs-3960	33	21	the	the	DET
gs-3960	33	22	disease	disease	NOUN
gs-3960	33	23	.	.	PUNCT
gs-3960	34	1	mitochondria	mitochondria	PROPN
gs-3960	34	2	play	play	VERB
gs-3960	34	3	an	an	DET
gs-3960	34	4	indispensable	indispensable	ADJ
gs-3960	34	5	role	role	NOUN
gs-3960	34	6	in	in	ADP
gs-3960	34	7	neuronal	neuronal	ADJ
gs-3960	34	8	homeostasis	homeostasis	NOUN
gs-3960	34	9	by	by	ADP
gs-3960	34	10	regulating	regulate	VERB
gs-3960	34	11	atp	atp	NOUN
gs-3960	34	12	production	production	NOUN
gs-3960	34	13	,	,	PUNCT
gs-3960	34	14	calcium	calcium	NOUN
gs-3960	34	15	buffering	buffering	NOUN
gs-3960	34	16	,	,	PUNCT
gs-3960	34	17	redox	redox	NOUN
gs-3960	34	18	signaling	signaling	NOUN
gs-3960	34	19	,	,	PUNCT
gs-3960	34	20	and	and	CCONJ
gs-3960	34	21	apoptotic	apoptotic	ADJ
gs-3960	34	22	pathways	pathway	NOUN
gs-3960	34	23	.	.	PUNCT
gs-3960	35	1	impairment	impairment	ADJ
gs-3960	35	2	in	in	ADP
gs-3960	35	3	these	these	DET
gs-3960	35	4	mitochondrial	mitochondrial	ADJ
gs-3960	35	5	functions	function	NOUN
gs-3960	35	6	leads	lead	VERB
gs-3960	35	7	to	to	ADP
gs-3960	35	8	neuronal	neuronal	ADJ
gs-3960	35	9	vulnerability	vulnerability	NOUN
gs-3960	35	10	and	and	CCONJ
gs-3960	35	11	degeneration	degeneration	NOUN
gs-3960	35	12	[	[	X
gs-3960	35	13	8	8	NUM
gs-3960	35	14	-	-	SYM
gs-3960	35	15	13	13	NUM
gs-3960	35	16	]	]	PUNCT
gs-3960	35	17	.	.	PUNCT
gs-3960	36	1	one	one	NUM
gs-3960	36	2	of	of	ADP
gs-3960	36	3	the	the	DET
gs-3960	36	4	pivotal	pivotal	ADJ
gs-3960	36	5	mitochondrial	mitochondrial	ADJ
gs-3960	36	6	quality	quality	NOUN
gs-3960	36	7	control	control	NOUN
gs-3960	36	8	mechanisms	mechanism	NOUN
gs-3960	36	9	implicated	implicate	VERB
gs-3960	36	10	in	in	ADP
gs-3960	36	11	pd	pd	PROPN
gs-3960	36	12	is	be	AUX
gs-3960	36	13	mitophagy	mitophagy	ADJ
gs-3960	36	14	,	,	PUNCT
gs-3960	36	15	a	a	DET
gs-3960	36	16	specialized	specialized	ADJ
gs-3960	36	17	form	form	NOUN
gs-3960	36	18	of	of	ADP
gs-3960	36	19	autophagy	autophagy	NOUN
gs-3960	36	20	responsible	responsible	ADJ
gs-3960	36	21	for	for	ADP
gs-3960	36	22	the	the	DET
gs-3960	36	23	selective	selective	ADJ
gs-3960	36	24	clearance	clearance	NOUN
gs-3960	36	25	of	of	ADP
gs-3960	36	26	damaged	damaged	ADJ
gs-3960	36	27	or	or	CCONJ
gs-3960	36	28	dysfunctional	dysfunctional	ADJ
gs-3960	36	29	mitochondria	mitochondria	NOUN
gs-3960	36	30	.	.	PUNCT
gs-3960	37	1	defective	defective	ADJ
gs-3960	37	2	mitophagy	mitophagy	NOUN
gs-3960	37	3	has	have	AUX
gs-3960	37	4	been	be	AUX
gs-3960	37	5	closely	closely	ADV
gs-3960	37	6	associated	associate	VERB
gs-3960	37	7	with	with	ADP
gs-3960	37	8	mutations	mutation	NOUN
gs-3960	37	9	in	in	ADP
gs-3960	37	10	pd	pd	NOUN
gs-3960	37	11	-	-	PUNCT
gs-3960	37	12	linked	link	VERB
gs-3960	37	13	genes	gene	NOUN
gs-3960	37	14	such	such	ADJ
gs-3960	37	15	as	as	ADP
gs-3960	37	16	pink1	pink1	NOUN
gs-3960	37	17	and	and	CCONJ
gs-3960	37	18	parkin	parkin	NOUN
gs-3960	37	19	,	,	PUNCT
gs-3960	37	20	which	which	PRON
gs-3960	37	21	orchestrate	orchestrate	VERB
gs-3960	37	22	the	the	DET
gs-3960	37	23	recognition	recognition	NOUN
gs-3960	37	24	and	and	CCONJ
gs-3960	37	25	removal	removal	NOUN
gs-3960	37	26	of	of	ADP
gs-3960	37	27	impaired	impaired	ADJ
gs-3960	37	28	mitochondria	mitochondria	NOUN
gs-3960	37	29	.	.	PUNCT
gs-3960	38	1	disruption	disruption	NOUN
gs-3960	38	2	in	in	ADP
gs-3960	38	3	this	this	DET
gs-3960	38	4	process	process	NOUN
gs-3960	38	5	results	result	VERB
gs-3960	38	6	in	in	ADP
gs-3960	38	7	the	the	DET
gs-3960	38	8	accumulation	accumulation	NOUN
gs-3960	38	9	of	of	ADP
gs-3960	38	10	dysfunctional	dysfunctional	ADJ
gs-3960	38	11	mitochondria	mitochondria	NOUN
gs-3960	38	12	,	,	PUNCT
gs-3960	38	13	increased	increase	VERB
gs-3960	38	14	oxidative	oxidative	ADJ
gs-3960	38	15	stress	stress	NOUN
gs-3960	38	16	,	,	PUNCT
gs-3960	38	17	and	and	CCONJ
gs-3960	38	18	ultimately	ultimately	ADV
gs-3960	38	19	,	,	PUNCT
gs-3960	38	20	neuronal	neuronal	ADJ
gs-3960	38	21	cell	cell	NOUN
gs-3960	38	22	death	death	NOUN
gs-3960	38	23	.	.	PUNCT
gs-3960	39	1	therefore	therefore	ADV
gs-3960	39	2	,	,	PUNCT
gs-3960	39	3	understanding	understand	VERB
gs-3960	39	4	the	the	DET
gs-3960	39	5	molecular	molecular	ADJ
gs-3960	39	6	mechanisms	mechanism	NOUN
gs-3960	39	7	governing	govern	VERB
gs-3960	39	8	mitophagy	mitophagy	NOUN
gs-3960	39	9	has	have	AUX
gs-3960	39	10	opened	open	VERB
gs-3960	39	11	new	new	ADJ
gs-3960	39	12	avenues	avenue	NOUN
gs-3960	39	13	for	for	ADP
gs-3960	39	14	therapeutic	therapeutic	ADJ
gs-3960	39	15	intervention	intervention	NOUN
gs-3960	39	16	in	in	ADP
gs-3960	39	17	pd	pd	PROPN
gs-3960	40	1	[	[	X
gs-3960	40	2	14	14	NUM
gs-3960	40	3	-	-	SYM
gs-3960	40	4	16	16	NUM
gs-3960	40	5	]	]	PUNCT
gs-3960	40	6	.	.	PUNCT
gs-3960	41	1	another	another	DET
gs-3960	41	2	critical	critical	ADJ
gs-3960	41	3	factor	factor	NOUN
gs-3960	41	4	in	in	ADP
gs-3960	41	5	mitochondrial	mitochondrial	ADJ
gs-3960	41	6	and	and	CCONJ
gs-3960	41	7	neuronal	neuronal	ADJ
gs-3960	41	8	health	health	NOUN
gs-3960	41	9	is	be	AUX
gs-3960	41	10	the	the	DET
gs-3960	41	11	maintenance	maintenance	NOUN
gs-3960	41	12	of	of	ADP
gs-3960	41	13	adequate	adequate	ADJ
gs-3960	41	14	nicotinamide	nicotinamide	NOUN
gs-3960	41	15	adenine	adenine	ADJ
gs-3960	41	16	dinucleotide	dinucleotide	NOUN
gs-3960	41	17	(	(	PUNCT
gs-3960	41	18	nad	nad	ADJ
gs-3960	41	19	)	)	PUNCT
gs-3960	41	20	levels	level	NOUN
gs-3960	41	21	.	.	PUNCT
gs-3960	42	1	nad	nad	PROPN
gs-3960	42	2	is	be	AUX
gs-3960	42	3	a	a	DET
gs-3960	42	4	vital	vital	ADJ
gs-3960	42	5	coenzyme	coenzyme	NOUN
gs-3960	42	6	georgian	georgian	NOUN
gs-3960	42	7	scientists/	scientists/	NUM
gs-3960	42	8	.	.	PUNCT
gs-3960	43	1	7	7	NUM
gs-3960	43	2	n	n	PRON
gs-3960	43	3	3	3	NUM
gs-3960	43	4	,	,	PUNCT
gs-3960	43	5	2025	2025	NUM
gs-3960	43	6	400	400	NUM
gs-3960	43	7	involved	involve	VERB
gs-3960	43	8	in	in	ADP
gs-3960	43	9	redox	redox	ADJ
gs-3960	43	10	reactions	reaction	NOUN
gs-3960	43	11	,	,	PUNCT
gs-3960	43	12	energy	energy	NOUN
gs-3960	43	13	metabolism	metabolism	NOUN
gs-3960	43	14	,	,	PUNCT
gs-3960	43	15	and	and	CCONJ
gs-3960	43	16	the	the	DET
gs-3960	43	17	regulation	regulation	NOUN
gs-3960	43	18	of	of	ADP
gs-3960	43	19	sirtuins	sirtuin	NOUN
gs-3960	43	20	and	and	CCONJ
gs-3960	43	21	poly(adp	poly(adp	NOUN
gs-3960	43	22	-	-	PUNCT
gs-3960	43	23	ribose	ribose	NOUN
gs-3960	43	24	)	)	PUNCT
gs-3960	43	25	polymerases	polymerase	NOUN
gs-3960	43	26	(	(	PUNCT
gs-3960	43	27	parps	parps	PROPN
gs-3960	43	28	)	)	PUNCT
gs-3960	43	29	,	,	PUNCT
gs-3960	43	30	which	which	PRON
gs-3960	43	31	are	be	AUX
gs-3960	43	32	essential	essential	ADJ
gs-3960	43	33	for	for	ADP
gs-3960	43	34	dna	dna	PROPN
gs-3960	43	35	repair	repair	NOUN
gs-3960	43	36	and	and	CCONJ
gs-3960	43	37	mitochondrial	mitochondrial	ADJ
gs-3960	43	38	function	function	NOUN
gs-3960	43	39	.	.	PUNCT
gs-3960	44	1	age	age	NOUN
gs-3960	44	2	-	-	PUNCT
gs-3960	44	3	related	relate	VERB
gs-3960	44	4	decline	decline	NOUN
gs-3960	44	5	in	in	ADP
gs-3960	44	6	nad	nad	ADJ
gs-3960	44	7	levels	level	NOUN
gs-3960	44	8	has	have	AUX
gs-3960	44	9	been	be	AUX
gs-3960	44	10	linked	link	VERB
gs-3960	44	11	to	to	ADP
gs-3960	44	12	metabolic	metabolic	NOUN
gs-3960	44	13	dysregulation	dysregulation	NOUN
gs-3960	44	14	,	,	PUNCT
gs-3960	44	15	mitochondrial	mitochondrial	ADJ
gs-3960	44	16	dysfunction	dysfunction	NOUN
gs-3960	44	17	,	,	PUNCT
gs-3960	44	18	and	and	CCONJ
gs-3960	44	19	neurodegeneration	neurodegeneration	NOUN
gs-3960	44	20	.	.	PUNCT
gs-3960	45	1	restoring	restore	VERB
gs-3960	45	2	nad	nad	ADJ
gs-3960	45	3	levels	level	NOUN
gs-3960	45	4	through	through	ADP
gs-3960	45	5	precursors	precursor	NOUN
gs-3960	45	6	such	such	ADJ
gs-3960	45	7	as	as	ADP
gs-3960	45	8	nicotinamide	nicotinamide	NOUN
gs-3960	45	9	riboside	riboside	NOUN
gs-3960	45	10	or	or	CCONJ
gs-3960	45	11	nicotinamide	nicotinamide	NOUN
gs-3960	45	12	mononucleotide	mononucleotide	NOUN
gs-3960	45	13	has	have	AUX
gs-3960	45	14	demonstrated	demonstrate	VERB
gs-3960	45	15	neuroprotective	neuroprotective	ADJ
gs-3960	45	16	effects	effect	NOUN
gs-3960	45	17	in	in	ADP
gs-3960	45	18	various	various	ADJ
gs-3960	45	19	models	model	NOUN
gs-3960	45	20	of	of	ADP
gs-3960	45	21	pd	pd	PROPN
gs-3960	45	22	and	and	CCONJ
gs-3960	45	23	other	other	ADJ
gs-3960	45	24	age	age	NOUN
gs-3960	45	25	-	-	PUNCT
gs-3960	45	26	related	relate	VERB
gs-3960	45	27	disorders	disorder	NOUN
gs-3960	45	28	,	,	PUNCT
gs-3960	45	29	highlighting	highlight	VERB
gs-3960	45	30	its	its	PRON
gs-3960	45	31	therapeutic	therapeutic	ADJ
gs-3960	45	32	potential	potential	NOUN
gs-3960	45	33	[	[	X
gs-3960	45	34	17	17	NUM
gs-3960	45	35	-	-	SYM
gs-3960	45	36	19	19	NUM
gs-3960	45	37	]	]	PUNCT
gs-3960	45	38	.	.	PUNCT
gs-3960	46	1	recent	recent	ADJ
gs-3960	46	2	studies	study	NOUN
gs-3960	46	3	have	have	AUX
gs-3960	46	4	elucidated	elucidate	VERB
gs-3960	46	5	complex	complex	ADJ
gs-3960	46	6	interactions	interaction	NOUN
gs-3960	46	7	between	between	ADP
gs-3960	46	8	impaired	impaired	ADJ
gs-3960	46	9	mitophagy	mitophagy	NOUN
gs-3960	46	10	,	,	PUNCT
gs-3960	46	11	decreased	decrease	VERB
gs-3960	46	12	nad	nad	ADJ
gs-3960	46	13	bioavailability	bioavailability	NOUN
gs-3960	46	14	,	,	PUNCT
gs-3960	46	15	and	and	CCONJ
gs-3960	46	16	oxidative	oxidative	ADJ
gs-3960	46	17	stress	stress	NOUN
gs-3960	46	18	in	in	ADP
gs-3960	46	19	the	the	DET
gs-3960	46	20	pathogenesis	pathogenesis	NOUN
gs-3960	46	21	of	of	ADP
gs-3960	46	22	pd	pd	PROPN
gs-3960	46	23	.	.	PUNCT
gs-3960	47	1	these	these	DET
gs-3960	47	2	interconnected	interconnected	ADJ
gs-3960	47	3	pathways	pathway	NOUN
gs-3960	47	4	suggest	suggest	VERB
gs-3960	47	5	that	that	SCONJ
gs-3960	47	6	combined	combine	VERB
gs-3960	47	7	therapeutic	therapeutic	ADJ
gs-3960	47	8	strategies	strategy	NOUN
gs-3960	47	9	aimed	aim	VERB
gs-3960	47	10	at	at	ADP
gs-3960	47	11	enhancing	enhance	VERB
gs-3960	47	12	mitophagy	mitophagy	NOUN
gs-3960	47	13	and	and	CCONJ
gs-3960	47	14	replenishing	replenish	VERB
gs-3960	47	15	nad	nad	NOUN
gs-3960	47	16	could	could	AUX
gs-3960	47	17	offer	offer	VERB
gs-3960	47	18	synergistic	synergistic	ADJ
gs-3960	47	19	benefits	benefit	NOUN
gs-3960	47	20	in	in	ADP
gs-3960	47	21	slowing	slow	VERB
gs-3960	47	22	disease	disease	NOUN
gs-3960	47	23	progression	progression	NOUN
gs-3960	47	24	and	and	CCONJ
gs-3960	47	25	preserving	preserve	VERB
gs-3960	47	26	neuronal	neuronal	ADJ
gs-3960	47	27	integrity	integrity	NOUN
gs-3960	47	28	.	.	PUNCT
gs-3960	48	1	additionally	additionally	ADV
gs-3960	48	2	,	,	PUNCT
gs-3960	48	3	pharmacological	pharmacological	ADJ
gs-3960	48	4	agents	agent	NOUN
gs-3960	48	5	that	that	PRON
gs-3960	48	6	target	target	VERB
gs-3960	48	7	mitochondrial	mitochondrial	ADJ
gs-3960	48	8	biogenesis	biogenesis	NOUN
gs-3960	48	9	,	,	PUNCT
gs-3960	48	10	dynamics	dynamic	NOUN
gs-3960	48	11	,	,	PUNCT
gs-3960	48	12	and	and	CCONJ
gs-3960	48	13	antioxidant	antioxidant	ADJ
gs-3960	48	14	defenses	defense	NOUN
gs-3960	48	15	are	be	AUX
gs-3960	48	16	under	under	ADP
gs-3960	48	17	active	active	ADJ
gs-3960	48	18	investigation	investigation	NOUN
gs-3960	48	19	and	and	CCONJ
gs-3960	48	20	may	may	AUX
gs-3960	48	21	complement	complement	VERB
gs-3960	48	22	existing	exist	VERB
gs-3960	48	23	dopaminergic	dopaminergic	ADJ
gs-3960	48	24	therapies	therapy	NOUN
gs-3960	48	25	[	[	X
gs-3960	48	26	20	20	NUM
gs-3960	48	27	-	-	SYM
gs-3960	48	28	22	22	NUM
gs-3960	48	29	]	]	PUNCT
gs-3960	48	30	.	.	PUNCT
gs-3960	49	1	this	this	DET
gs-3960	49	2	study	study	NOUN
gs-3960	49	3	aims	aim	VERB
gs-3960	49	4	to	to	PART
gs-3960	49	5	provide	provide	VERB
gs-3960	49	6	a	a	DET
gs-3960	49	7	comprehensive	comprehensive	ADJ
gs-3960	49	8	overview	overview	NOUN
gs-3960	49	9	of	of	ADP
gs-3960	49	10	the	the	DET
gs-3960	49	11	mechanistic	mechanistic	ADJ
gs-3960	49	12	underpinnings	underpinning	NOUN
gs-3960	49	13	of	of	ADP
gs-3960	49	14	mitochondrial	mitochondrial	ADJ
gs-3960	49	15	dysfunction	dysfunction	NOUN
gs-3960	49	16	in	in	ADP
gs-3960	49	17	pd	pd	PROPN
gs-3960	49	18	,	,	PUNCT
gs-3960	49	19	with	with	ADP
gs-3960	49	20	a	a	DET
gs-3960	49	21	focused	focused	ADJ
gs-3960	49	22	analysis	analysis	NOUN
gs-3960	49	23	of	of	ADP
gs-3960	49	24	mitophagy	mitophagy	NOUN
gs-3960	49	25	and	and	CCONJ
gs-3960	49	26	nad	nad	ADJ
gs-3960	49	27	metabolism	metabolism	NOUN
gs-3960	49	28	.	.	PUNCT
gs-3960	50	1	it	it	PRON
gs-3960	50	2	also	also	ADV
gs-3960	50	3	explores	explore	VERB
gs-3960	50	4	current	current	ADJ
gs-3960	50	5	and	and	CCONJ
gs-3960	50	6	emerging	emerge	VERB
gs-3960	50	7	therapeutic	therapeutic	ADJ
gs-3960	50	8	strategies	strategy	NOUN
gs-3960	50	9	targeting	target	VERB
gs-3960	50	10	these	these	DET
gs-3960	50	11	pathways	pathway	NOUN
gs-3960	50	12	,	,	PUNCT
gs-3960	50	13	with	with	ADP
gs-3960	50	14	the	the	DET
gs-3960	50	15	goal	goal	NOUN
gs-3960	50	16	of	of	ADP
gs-3960	50	17	developing	develop	VERB
gs-3960	50	18	more	more	ADV
gs-3960	50	19	effective	effective	ADJ
gs-3960	50	20	,	,	PUNCT
gs-3960	50	21	disease	disease	NOUN
gs-3960	50	22	-	-	PUNCT
gs-3960	50	23	modifying	modify	VERB
gs-3960	50	24	treatments	treatment	NOUN
gs-3960	50	25	for	for	ADP
gs-3960	50	26	parkinson	parkinson	NOUN
gs-3960	50	27	's	's	PART
gs-3960	50	28	disease	disease	NOUN
gs-3960	50	29	.	.	PUNCT
gs-3960	51	1	by	by	ADP
gs-3960	51	2	bridging	bridge	VERB
gs-3960	51	3	molecular	molecular	ADJ
gs-3960	51	4	insights	insight	NOUN
gs-3960	51	5	with	with	ADP
gs-3960	51	6	translational	translational	ADJ
gs-3960	51	7	potential	potential	NOUN
gs-3960	51	8	,	,	PUNCT
gs-3960	51	9	this	this	DET
gs-3960	51	10	work	work	NOUN
gs-3960	51	11	underscores	underscore	VERB
gs-3960	51	12	the	the	DET
gs-3960	51	13	centrality	centrality	NOUN
gs-3960	51	14	of	of	ADP
gs-3960	51	15	mitochondrial	mitochondrial	ADJ
gs-3960	51	16	health	health	NOUN
gs-3960	51	17	in	in	ADP
gs-3960	51	18	neurodegenerative	neurodegenerative	ADJ
gs-3960	51	19	disease	disease	NOUN
gs-3960	51	20	management	management	NOUN
gs-3960	51	21	and	and	CCONJ
gs-3960	51	22	highlights	highlight	NOUN
gs-3960	51	23	promising	promise	VERB
gs-3960	51	24	directions	direction	NOUN
gs-3960	51	25	for	for	ADP
gs-3960	51	26	future	future	ADJ
gs-3960	51	27	research	research	NOUN
gs-3960	51	28	and	and	CCONJ
gs-3960	51	29	clinical	clinical	ADJ
gs-3960	51	30	intervention	intervention	NOUN
gs-3960	51	31	[	[	X
gs-3960	51	32	23	23	NUM
gs-3960	51	33	-	-	SYM
gs-3960	51	34	24	24	NUM
gs-3960	51	35	]	]	PUNCT
gs-3960	51	36	.	.	PUNCT
gs-3960	52	1	the	the	DET
gs-3960	52	2	study	study	NOUN
gs-3960	52	3	explores	explore	VERB
gs-3960	52	4	the	the	DET
gs-3960	52	5	intricate	intricate	ADJ
gs-3960	52	6	relationship	relationship	NOUN
gs-3960	52	7	between	between	ADP
gs-3960	52	8	mitochondrial	mitochondrial	ADJ
gs-3960	52	9	dysfunction	dysfunction	NOUN
gs-3960	52	10	,	,	PUNCT
gs-3960	52	11	mitophagy	mitophagy	NOUN
gs-3960	52	12	,	,	PUNCT
gs-3960	52	13	and	and	CCONJ
gs-3960	52	14	nad+	nad+	PROPN
gs-3960	52	15	metabolism	metabolism	NOUN
gs-3960	52	16	in	in	ADP
gs-3960	52	17	pd	pd	PROPN
gs-3960	52	18	.	.	PUNCT
gs-3960	53	1	we	we	PRON
gs-3960	53	2	also	also	ADV
gs-3960	53	3	highlight	highlight	VERB
gs-3960	53	4	potential	potential	ADJ
gs-3960	53	5	therapeutic	therapeutic	ADJ
gs-3960	53	6	strategies	strategy	NOUN
gs-3960	53	7	targeting	target	VERB
gs-3960	53	8	these	these	DET
gs-3960	53	9	pathways	pathway	NOUN
gs-3960	53	10	,	,	PUNCT
gs-3960	53	11	emphasizing	emphasize	VERB
gs-3960	53	12	their	their	PRON
gs-3960	53	13	relevance	relevance	NOUN
gs-3960	53	14	in	in	ADP
gs-3960	53	15	developing	develop	VERB
gs-3960	53	16	neuroprotective	neuroprotective	ADJ
gs-3960	53	17	interventions	intervention	NOUN
gs-3960	53	18	for	for	ADP
gs-3960	53	19	pd	pd	PROPN
gs-3960	54	1	[	[	X
gs-3960	54	2	25	25	NUM
gs-3960	54	3	-	-	SYM
gs-3960	54	4	27	27	NUM
gs-3960	54	5	]	]	PUNCT
gs-3960	54	6	.	.	PUNCT
gs-3960	55	1	characterized	characterize	VERB
gs-3960	55	2	by	by	ADP
gs-3960	55	3	the	the	DET
gs-3960	55	4	progressive	progressive	ADJ
gs-3960	55	5	loss	loss	NOUN
gs-3960	55	6	of	of	ADP
gs-3960	55	7	dopaminergic	dopaminergic	ADJ
gs-3960	55	8	neurons	neuron	NOUN
gs-3960	55	9	in	in	ADP
gs-3960	55	10	the	the	DET
gs-3960	55	11	substantia	substantia	NOUN
gs-3960	55	12	nigra	nigra	PROPN
gs-3960	55	13	pars	par	NOUN
gs-3960	55	14	compacta	compacta	NOUN
gs-3960	55	15	and	and	CCONJ
gs-3960	55	16	the	the	DET
gs-3960	55	17	accumulation	accumulation	NOUN
gs-3960	55	18	of	of	ADP
gs-3960	55	19	misfolded	misfolde	VERB
gs-3960	55	20	-synuclein	-synuclein	PROPN
gs-3960	55	21	aggregates	aggregate	NOUN
gs-3960	55	22	,	,	PUNCT
gs-3960	55	23	known	know	VERB
gs-3960	55	24	as	as	ADP
gs-3960	55	25	lewy	lewy	PROPN
gs-3960	55	26	are	be	AUX
gs-3960	55	27	multifaceted	multifacete	VERB
gs-3960	55	28	,	,	PUNCT
gs-3960	55	29	involving	involve	VERB
gs-3960	55	30	genetic	genetic	ADJ
gs-3960	55	31	predispositions	predisposition	NOUN
gs-3960	55	32	,	,	PUNCT
gs-3960	55	33	environmental	environmental	ADJ
gs-3960	55	34	factors	factor	NOUN
gs-3960	55	35	,	,	PUNCT
gs-3960	55	36	and	and	CCONJ
gs-3960	55	37	intricate	intricate	ADJ
gs-3960	55	38	cellular	cellular	ADJ
gs-3960	55	39	dysfunctions	dysfunction	NOUN
gs-3960	55	40	.	.	PUNCT
gs-3960	56	1	among	among	ADP
gs-3960	56	2	these	these	PRON
gs-3960	56	3	,	,	PUNCT
gs-3960	56	4	mitochondrial	mitochondrial	ADJ
gs-3960	56	5	dysfunction	dysfunction	NOUN
gs-3960	56	6	has	have	AUX
gs-3960	56	7	emerged	emerge	VERB
gs-3960	56	8	as	as	ADP
gs-3960	56	9	a	a	DET
gs-3960	56	10	central	central	ADJ
gs-3960	56	11	player	player	NOUN
gs-3960	56	12	in	in	ADP
gs-3960	56	13	the	the	DET
gs-3960	56	14	pathogenesis	pathogenesis	NOUN
gs-3960	56	15	of	of	ADP
gs-3960	56	16	the	the	DET
gs-3960	56	17	disease	disease	NOUN
gs-3960	56	18	,	,	PUNCT
gs-3960	56	19	influencing	influence	VERB
gs-3960	56	20	both	both	CCONJ
gs-3960	56	21	sporadic	sporadic	ADJ
gs-3960	56	22	and	and	CCONJ
gs-3960	56	23	familial	familial	ADJ
gs-3960	56	24	forms	form	NOUN
gs-3960	56	25	of	of	ADP
gs-3960	56	26	regulating	regulate	VERB
gs-3960	56	27	redox	redox	NOUN
gs-3960	56	28	balance	balance	NOUN
gs-3960	56	29	,	,	PUNCT
gs-3960	56	30	and	and	CCONJ
gs-3960	56	31	ensuring	ensure	VERB
gs-3960	56	32	neuronal	neuronal	ADJ
gs-3960	56	33	survival	survival	NOUN
gs-3960	56	34	underscores	underscore	VERB
gs-3960	56	35	why	why	SCONJ
gs-3960	56	36	their	their	PRON
gs-3960	56	37	impairment	impairment	NOUN
gs-3960	56	38	leads	lead	VERB
gs-3960	56	39	to	to	ADP
gs-3960	56	40	such	such	ADJ
gs-3960	56	41	devastating	devastating	ADJ
gs-3960	56	42	consequences	consequence	NOUN
gs-3960	56	43	in	in	ADP
gs-3960	56	44	the	the	DET
gs-3960	56	45	brain	brain	NOUN
gs-3960	57	1	[	[	X
gs-3960	57	2	28	28	NUM
gs-3960	57	3	-	-	SYM
gs-3960	57	4	30	30	NUM
gs-3960	57	5	]	]	PUNCT
gs-3960	57	6	.	.	PUNCT
gs-3960	58	1	mitochondria	mitochondria	PROPN
gs-3960	58	2	are	be	AUX
gs-3960	58	3	dynamic	dynamic	ADJ
gs-3960	58	4	organelles	organelle	NOUN
gs-3960	58	5	responsible	responsible	ADJ
gs-3960	58	6	for	for	ADP
gs-3960	58	7	adenosine	adenosine	ADJ
gs-3960	58	8	triphosphate	triphosphate	NOUN
gs-3960	58	9	production	production	NOUN
gs-3960	58	10	through	through	ADP
gs-3960	58	11	oxidative	oxidative	ADJ
gs-3960	58	12	phosphorylation	phosphorylation	NOUN
gs-3960	58	13	,	,	PUNCT
gs-3960	58	14	a	a	DET
gs-3960	58	15	process	process	NOUN
gs-3960	58	16	inherently	inherently	ADV
gs-3960	58	17	linked	link	VERB
gs-3960	58	18	to	to	ADP
gs-3960	58	19	the	the	DET
gs-3960	58	20	generation	generation	NOUN
gs-3960	58	21	of	of	ADP
gs-3960	58	22	reactive	reactive	ADJ
gs-3960	58	23	oxygen	oxygen	NOUN
gs-3960	58	24	species	specie	NOUN
gs-3960	58	25	.	.	PUNCT
gs-3960	59	1	in	in	ADP
gs-3960	59	2	healthy	healthy	ADJ
gs-3960	59	3	neurons	neuron	NOUN
gs-3960	59	4	,	,	PUNCT
gs-3960	59	5	robust	robust	ADJ
gs-3960	59	6	quality	quality	NOUN
gs-3960	59	7	control	control	NOUN
gs-3960	59	8	mechanisms	mechanism	NOUN
gs-3960	59	9	,	,	PUNCT
gs-3960	59	10	including	include	VERB
gs-3960	59	11	mitochondrial	mitochondrial	ADJ
gs-3960	59	12	biogenesis	biogenesis	NOUN
gs-3960	59	13	,	,	PUNCT
gs-3960	59	14	fission	fission	NOUN
gs-3960	59	15	,	,	PUNCT
gs-3960	59	16	fusion	fusion	NOUN
gs-3960	59	17	,	,	PUNCT
gs-3960	59	18	and	and	CCONJ
gs-3960	59	19	mitophagy	mitophagy	NOUN
gs-3960	59	20	,	,	PUNCT
gs-3960	59	21	work	work	VERB
gs-3960	59	22	in	in	ADP
gs-3960	59	23	georgian	georgian	PROPN
gs-3960	59	24	scientists/	scientists/	NUM
gs-3960	59	25	.	.	PUNCT
gs-3960	59	26	7	7	NUM
gs-3960	59	27	n	n	PRON
gs-3960	59	28	3	3	NUM
gs-3960	59	29	,	,	PUNCT
gs-3960	59	30	2025	2025	NUM
gs-3960	59	31	401	401	NUM
gs-3960	59	32	processes	process	NOUN
gs-3960	59	33	become	become	VERB
gs-3960	59	34	dysregulated	dysregulated	ADJ
gs-3960	59	35	,	,	PUNCT
gs-3960	59	36	leading	lead	VERB
gs-3960	59	37	to	to	ADP
gs-3960	59	38	the	the	DET
gs-3960	59	39	accumulation	accumulation	NOUN
gs-3960	59	40	of	of	ADP
gs-3960	59	41	damaged	damage	VERB
gs-3960	59	42	mitochondria	mitochondria	NOUN
gs-3960	59	43	,	,	PUNCT
gs-3960	59	44	bioenergetic	bioenergetic	ADJ
gs-3960	59	45	failure	failure	NOUN
gs-3960	59	46	,	,	PUNCT
gs-3960	59	47	and	and	CCONJ
gs-3960	59	48	ultimately	ultimately	ADV
gs-3960	59	49	,	,	PUNCT
gs-3960	59	50	neuronal	neuronal	ADJ
gs-3960	59	51	death	death	NOUN
gs-3960	59	52	.	.	PUNCT
gs-3960	60	1	the	the	DET
gs-3960	60	2	selective	selective	ADJ
gs-3960	60	3	degradation	degradation	NOUN
gs-3960	60	4	of	of	ADP
gs-3960	60	5	impaired	impaired	ADJ
gs-3960	60	6	mitochondria	mitochondria	NOUN
gs-3960	60	7	via	via	ADP
gs-3960	60	8	mitophagy	mitophagy	NOUN
gs-3960	60	9	is	be	AUX
gs-3960	60	10	particularly	particularly	ADV
gs-3960	60	11	crucial	crucial	ADJ
gs-3960	60	12	,	,	PUNCT
gs-3960	60	13	as	as	SCONJ
gs-3960	60	14	its	its	PRON
gs-3960	60	15	failure	failure	NOUN
gs-3960	60	16	results	result	VERB
gs-3960	60	17	in	in	ADP
gs-3960	60	18	the	the	DET
gs-3960	60	19	persistence	persistence	NOUN
gs-3960	60	20	of	of	ADP
gs-3960	60	21	dysfunctional	dysfunctional	ADJ
gs-3960	60	22	organelles	organelle	NOUN
gs-3960	60	23	that	that	PRON
gs-3960	60	24	perpetuate	perpetuate	VERB
gs-3960	60	25	oxidative	oxidative	ADJ
gs-3960	60	26	stress	stress	NOUN
gs-3960	60	27	and	and	CCONJ
gs-3960	60	28	metabolic	metabolic	NOUN
gs-3960	60	29	disturbances	disturbance	NOUN
gs-3960	60	30	.	.	PUNCT
gs-3960	61	1	key	key	ADJ
gs-3960	61	2	proteins	protein	NOUN
gs-3960	61	3	involved	involve	VERB
gs-3960	61	4	in	in	ADP
gs-3960	61	5	mitophagy	mitophagy	NOUN
gs-3960	61	6	,	,	PUNCT
gs-3960	61	7	such	such	ADJ
gs-3960	61	8	as	as	ADP
gs-3960	61	9	pink1	pink1	NOUN
gs-3960	61	10	and	and	CCONJ
gs-3960	61	11	parkin	parkin	NOUN
gs-3960	61	12	,	,	PUNCT
gs-3960	61	13	are	be	AUX
gs-3960	61	14	often	often	ADV
gs-3960	61	15	mutated	mutate	VERB
gs-3960	61	16	in	in	ADP
gs-3960	61	17	familial	familial	ADJ
gs-3960	61	18	fundamental	fundamental	ADJ
gs-3960	61	19	contributor	contributor	NOUN
gs-3960	61	20	to	to	ADP
gs-3960	61	21	the	the	DET
gs-3960	61	22	disease	disease	NOUN
gs-3960	61	23	[	[	X
gs-3960	61	24	75	75	NUM
gs-3960	61	25	-	-	SYM
gs-3960	61	26	76	76	NUM
gs-3960	61	27	]	]	PUNCT
gs-3960	61	28	.	.	PUNCT
gs-3960	62	1	beyond	beyond	ADP
gs-3960	62	2	mitophagy	mitophagy	NOUN
gs-3960	62	3	,	,	PUNCT
gs-3960	62	4	another	another	DET
gs-3960	62	5	critical	critical	ADJ
gs-3960	62	6	aspect	aspect	NOUN
gs-3960	62	7	of	of	ADP
gs-3960	62	8	mitochondrial	mitochondrial	ADJ
gs-3960	62	9	health	health	NOUN
gs-3960	62	10	is	be	AUX
gs-3960	62	11	the	the	DET
gs-3960	62	12	regulation	regulation	NOUN
gs-3960	62	13	of	of	ADP
gs-3960	62	14	nicotinamide	nicotinamide	NOUN
gs-3960	62	15	adenine	adenine	NOUN
gs-3960	62	16	dinucleotide	dinucleotide	NOUN
gs-3960	62	17	metabolism	metabolism	NOUN
gs-3960	62	18	.	.	PUNCT
gs-3960	63	1	nad+	nad+	PROPN
gs-3960	63	2	serves	serve	VERB
gs-3960	63	3	as	as	ADP
gs-3960	63	4	an	an	DET
gs-3960	63	5	essential	essential	ADJ
gs-3960	63	6	cofactor	cofactor	NOUN
gs-3960	63	7	in	in	ADP
gs-3960	63	8	redox	redox	ADJ
gs-3960	63	9	reactions	reaction	NOUN
gs-3960	63	10	and	and	CCONJ
gs-3960	63	11	as	as	ADP
gs-3960	63	12	a	a	DET
gs-3960	63	13	substrate	substrate	NOUN
gs-3960	63	14	for	for	ADP
gs-3960	63	15	enzymes	enzyme	NOUN
gs-3960	63	16	involved	involve	VERB
gs-3960	63	17	in	in	ADP
gs-3960	63	18	dna	dna	PROPN
gs-3960	63	19	repair	repair	NOUN
gs-3960	63	20	,	,	PUNCT
gs-3960	63	21	cellular	cellular	ADJ
gs-3960	63	22	signaling	signaling	NOUN
gs-3960	63	23	,	,	PUNCT
gs-3960	63	24	and	and	CCONJ
gs-3960	63	25	energy	energy	NOUN
gs-3960	63	26	metabolism	metabolism	NOUN
gs-3960	63	27	.	.	PUNCT
gs-3960	64	1	age	age	NOUN
gs-3960	64	2	-	-	PUNCT
gs-3960	64	3	related	relate	VERB
gs-3960	64	4	decline	decline	NOUN
gs-3960	64	5	in	in	ADP
gs-3960	64	6	nad+	nad+	PROPN
gs-3960	64	7	levels	level	NOUN
gs-3960	64	8	has	have	AUX
gs-3960	64	9	been	be	AUX
gs-3960	64	10	implicated	implicate	VERB
gs-3960	64	11	in	in	ADP
gs-3960	64	12	various	various	ADJ
gs-3960	64	13	counteract	counteract	NOUN
gs-3960	64	14	stress	stress	NOUN
gs-3960	64	15	.	.	PUNCT
gs-3960	65	1	strategies	strategy	NOUN
gs-3960	65	2	aimed	aim	VERB
gs-3960	65	3	at	at	ADP
gs-3960	65	4	boosting	boost	VERB
gs-3960	65	5	nad+	nad+	PROPN
gs-3960	65	6	levels	level	NOUN
gs-3960	65	7	,	,	PUNCT
gs-3960	65	8	whether	whether	SCONJ
gs-3960	65	9	through	through	ADP
gs-3960	65	10	precursor	precursor	NOUN
gs-3960	65	11	supplementation	supplementation	NOUN
gs-3960	65	12	or	or	CCONJ
gs-3960	65	13	activation	activation	NOUN
gs-3960	65	14	of	of	ADP
gs-3960	65	15	salvage	salvage	NOUN
gs-3960	65	16	pathways	pathway	NOUN
gs-3960	65	17	,	,	PUNCT
gs-3960	65	18	have	have	AUX
gs-3960	65	19	shown	show	VERB
gs-3960	65	20	potential	potential	NOUN
gs-3960	65	21	in	in	ADP
gs-3960	65	22	restoring	restore	VERB
gs-3960	65	23	mitochondrial	mitochondrial	ADJ
gs-3960	65	24	function	function	NOUN
gs-3960	65	25	and	and	CCONJ
gs-3960	65	26	enhancing	enhance	VERB
gs-3960	65	27	neuronal	neuronal	ADJ
gs-3960	65	28	resilience	resilience	NOUN
gs-3960	65	29	in	in	ADP
gs-3960	65	30	preclinical	preclinical	ADJ
gs-3960	65	31	models	model	NOUN
gs-3960	65	32	[	[	X
gs-3960	65	33	77	77	NUM
gs-3960	65	34	-	-	SYM
gs-3960	65	35	78	78	NUM
gs-3960	65	36	]	]	PUNCT
gs-3960	65	37	.	.	PUNCT
gs-3960	66	1	the	the	DET
gs-3960	66	2	interplay	interplay	NOUN
gs-3960	66	3	between	between	ADP
gs-3960	66	4	mitophagy	mitophagy	NOUN
gs-3960	66	5	and	and	CCONJ
gs-3960	66	6	nad+	nad+	PROPN
gs-3960	66	7	metabolism	metabolism	NOUN
gs-3960	66	8	presents	present	VERB
gs-3960	66	9	a	a	DET
gs-3960	66	10	compelling	compelling	ADJ
gs-3960	66	11	avenue	avenue	NOUN
gs-3960	66	12	for	for	ADP
gs-3960	66	13	therapeutic	therapeutic	ADJ
gs-3960	66	14	intervention	intervention	NOUN
gs-3960	66	15	.	.	PUNCT
gs-3960	67	1	while	while	SCONJ
gs-3960	67	2	mitophagy	mitophagy	NOUN
gs-3960	67	3	ensures	ensure	VERB
gs-3960	67	4	the	the	DET
gs-3960	67	5	removal	removal	NOUN
gs-3960	67	6	of	of	ADP
gs-3960	67	7	damaged	damage	VERB
gs-3960	67	8	mitochondria	mitochondria	NOUN
gs-3960	67	9	,	,	PUNCT
gs-3960	67	10	nad+	nad+	PROPN
gs-3960	67	11	supports	support	VERB
gs-3960	67	12	the	the	DET
gs-3960	67	13	bioenergetic	bioenergetic	ADJ
gs-3960	67	14	and	and	CCONJ
gs-3960	67	15	reparative	reparative	ADJ
gs-3960	67	16	capacity	capacity	NOUN
gs-3960	67	17	of	of	ADP
gs-3960	67	18	the	the	DET
gs-3960	67	19	remaining	remain	VERB
gs-3960	67	20	healthy	healthy	ADJ
gs-3960	67	21	organelles	organelle	NOUN
gs-3960	67	22	.	.	PUNCT
gs-3960	68	1	together	together	ADV
gs-3960	68	2	,	,	PUNCT
gs-3960	68	3	these	these	DET
gs-3960	68	4	pathways	pathway	NOUN
gs-3960	68	5	influence	influence	VERB
gs-3960	68	6	critical	critical	ADJ
gs-3960	68	7	aspects	aspect	NOUN
gs-3960	68	8	of	of	ADP
gs-3960	68	9	neuronal	neuronal	ADJ
gs-3960	68	10	survival	survival	NOUN
gs-3960	68	11	,	,	PUNCT
gs-3960	68	12	including	include	VERB
gs-3960	68	13	calcium	calcium	NOUN
gs-3960	68	14	buffering	buffering	NOUN
gs-3960	68	15	,	,	PUNCT
gs-3960	68	16	apoptosis	apoptosis	NOUN
gs-3960	68	17	regulation	regulation	NOUN
gs-3960	68	18	,	,	PUNCT
gs-3960	68	19	and	and	CCONJ
gs-3960	68	20	neuroinflammation	neuroinflammation	NOUN
gs-3960	68	21	modulation	modulation	NOUN
gs-3960	68	22	.	.	PUNCT
gs-3960	69	1	making	make	VERB
gs-3960	69	2	their	their	PRON
gs-3960	69	3	restoration	restoration	NOUN
gs-3960	69	4	a	a	DET
gs-3960	69	5	promising	promising	ADJ
gs-3960	69	6	strategy	strategy	NOUN
gs-3960	69	7	for	for	ADP
gs-3960	69	8	slowing	slow	VERB
gs-3960	69	9	or	or	CCONJ
gs-3960	69	10	halting	halting	ADJ
gs-3960	69	11	neurodegeneration	neurodegeneration	NOUN
gs-3960	69	12	[	[	X
gs-3960	69	13	7980	7980	NUM
gs-3960	69	14	]	]	PUNCT
gs-3960	69	15	.	.	PUNCT
gs-3960	70	1	despite	despite	SCONJ
gs-3960	70	2	significant	significant	ADJ
gs-3960	70	3	advances	advance	NOUN
gs-3960	70	4	in	in	ADP
gs-3960	70	5	understanding	understand	VERB
gs-3960	70	6	mitochondrial	mitochondrial	ADJ
gs-3960	70	7	dysfunction	dysfunction	NOUN
gs-3960	70	8	in	in	ADP
gs-3960	70	9	therapies	therapy	NOUN
gs-3960	70	10	.	.	PUNCT
gs-3960	71	1	the	the	DET
gs-3960	71	2	complexity	complexity	NOUN
gs-3960	71	3	of	of	ADP
gs-3960	71	4	mitochondrial	mitochondrial	ADJ
gs-3960	71	5	biology	biology	NOUN
gs-3960	71	6	,	,	PUNCT
gs-3960	71	7	coupled	couple	VERB
gs-3960	71	8	with	with	ADP
gs-3960	71	9	the	the	DET
gs-3960	71	10	selective	selective	ADJ
gs-3960	71	11	vulnerability	vulnerability	NOUN
gs-3960	71	12	of	of	ADP
gs-3960	71	13	dopaminergic	dopaminergic	ADJ
gs-3960	71	14	neurons	neuron	NOUN
gs-3960	71	15	,	,	PUNCT
gs-3960	71	16	necessitates	necessitate	VERB
gs-3960	71	17	a	a	DET
gs-3960	71	18	nuanced	nuanced	ADJ
gs-3960	71	19	approach	approach	NOUN
gs-3960	71	20	to	to	ADP
gs-3960	71	21	treatment	treatment	NOUN
gs-3960	71	22	development	development	NOUN
gs-3960	71	23	.	.	PUNCT
gs-3960	72	1	current	current	ADJ
gs-3960	72	2	therapeutic	therapeutic	ADJ
gs-3960	72	3	strategies	strategy	NOUN
gs-3960	72	4	under	under	ADP
gs-3960	72	5	investigation	investigation	NOUN
gs-3960	72	6	include	include	VERB
gs-3960	72	7	pharmacological	pharmacological	ADJ
gs-3960	72	8	enhancers	enhancer	NOUN
gs-3960	72	9	of	of	ADP
gs-3960	72	10	mitophagy	mitophagy	NOUN
gs-3960	72	11	,	,	PUNCT
gs-3960	72	12	nad+	nad+	PROPN
gs-3960	72	13	precursors	precursor	NOUN
gs-3960	72	14	such	such	ADJ
gs-3960	72	15	as	as	ADP
gs-3960	72	16	nicotinamide	nicotinamide	NOUN
gs-3960	72	17	riboside	riboside	NOUN
gs-3960	72	18	and	and	CCONJ
gs-3960	72	19	nicotinamide	nicotinamide	NOUN
gs-3960	72	20	mononucleotide	mononucleotide	NOUN
gs-3960	72	21	,	,	PUNCT
gs-3960	72	22	and	and	CCONJ
gs-3960	72	23	compounds	compound	VERB
gs-3960	72	24	that	that	PRON
gs-3960	72	25	improve	improve	VERB
gs-3960	72	26	mitochondrial	mitochondrial	ADJ
gs-3960	72	27	biogenesis	biogenesis	NOUN
gs-3960	72	28	.	.	PUNCT
gs-3960	73	1	additionally	additionally	ADV
gs-3960	73	2	,	,	PUNCT
gs-3960	73	3	lifestyle	lifestyle	NOUN
gs-3960	73	4	interventions	intervention	NOUN
gs-3960	73	5	,	,	PUNCT
gs-3960	73	6	including	include	VERB
gs-3960	73	7	exercise	exercise	NOUN
gs-3960	73	8	and	and	CCONJ
gs-3960	73	9	dietary	dietary	ADJ
gs-3960	73	10	modifications	modification	NOUN
gs-3960	73	11	,	,	PUNCT
gs-3960	73	12	have	have	AUX
gs-3960	73	13	demonstrated	demonstrate	VERB
gs-3960	73	14	beneficial	beneficial	ADJ
gs-3960	73	15	effects	effect	NOUN
gs-3960	73	16	on	on	ADP
gs-3960	73	17	mitochondrial	mitochondrial	ADJ
gs-3960	73	18	health	health	NOUN
gs-3960	73	19	,	,	PUNCT
gs-3960	73	20	further	far	ADV
gs-3960	73	21	highlighting	highlight	VERB
gs-3960	73	22	the	the	DET
gs-3960	73	23	multifactorial	multifactorial	ADJ
gs-3960	73	24	nature	nature	NOUN
gs-3960	73	25	of	of	ADP
gs-3960	73	26	potential	potential	ADJ
gs-3960	73	27	treatments	treatment	NOUN
gs-3960	73	28	[	[	X
gs-3960	73	29	81	81	NUM
gs-3960	73	30	-	-	SYM
gs-3960	73	31	82	82	NUM
gs-3960	73	32	]	]	PUNCT
gs-3960	73	33	.	.	PUNCT
gs-3960	74	1	the	the	DET
gs-3960	74	2	study	study	NOUN
gs-3960	74	3	seeks	seek	VERB
gs-3960	74	4	to	to	PART
gs-3960	74	5	provide	provide	VERB
gs-3960	74	6	a	a	DET
gs-3960	74	7	comprehensive	comprehensive	ADJ
gs-3960	74	8	exploration	exploration	NOUN
gs-3960	74	9	of	of	ADP
gs-3960	74	10	mitochondrial	mitochondrial	ADJ
gs-3960	74	11	metabolism	metabolism	NOUN
gs-3960	74	12	as	as	ADP
gs-3960	74	13	key	key	ADJ
gs-3960	74	14	determinants	determinant	NOUN
gs-3960	74	15	of	of	ADP
gs-3960	74	16	neuronal	neuronal	ADJ
gs-3960	74	17	survival	survival	NOUN
gs-3960	74	18	.	.	PUNCT
gs-3960	75	1	by	by	ADP
gs-3960	75	2	examining	examine	VERB
gs-3960	75	3	the	the	DET
gs-3960	75	4	molecular	molecular	ADJ
gs-3960	75	5	mechanisms	mechanism	NOUN
gs-3960	75	6	underlying	underlie	VERB
gs-3960	75	7	these	these	DET
gs-3960	75	8	processes	process	NOUN
gs-3960	75	9	,	,	PUNCT
gs-3960	75	10	as	as	ADV
gs-3960	75	11	well	well	ADV
gs-3960	75	12	as	as	ADP
gs-3960	75	13	emerging	emerge	VERB
gs-3960	75	14	therapeutic	therapeutic	ADJ
gs-3960	75	15	strategies	strategy	NOUN
gs-3960	75	16	,	,	PUNCT
gs-3960	75	17	this	this	DET
gs-3960	75	18	review	review	NOUN
gs-3960	75	19	aims	aim	VERB
gs-3960	75	20	to	to	PART
gs-3960	75	21	shed	shed	VERB
gs-3960	75	22	light	light	NOUN
gs-3960	75	23	on	on	ADP
gs-3960	75	24	novel	novel	ADJ
gs-3960	75	25	approaches	approach	NOUN
gs-3960	75	26	for	for	ADP
gs-3960	75	27	mitigating	mitigate	VERB
gs-3960	75	28	neurodegeneration	neurodegeneration	NOUN
gs-3960	75	29	.	.	PUNCT
gs-3960	76	1	georgian	georgian	NOUN
gs-3960	76	2	scientists/	scientists/	NUM
gs-3960	76	3	.	.	PUNCT
gs-3960	77	1	7	7	NUM
gs-3960	77	2	n	n	PRON
gs-3960	77	3	3	3	NUM
gs-3960	77	4	,	,	PUNCT
gs-3960	77	5	2025	2025	NUM
gs-3960	77	6	402	402	NUM
gs-3960	77	7	furthermore	furthermore	ADV
gs-3960	77	8	,	,	PUNCT
gs-3960	77	9	it	it	PRON
gs-3960	77	10	addresses	address	VERB
gs-3960	77	11	the	the	DET
gs-3960	77	12	existing	exist	VERB
gs-3960	77	13	gaps	gap	NOUN
gs-3960	77	14	in	in	ADP
gs-3960	77	15	knowledge	knowledge	NOUN
gs-3960	77	16	and	and	CCONJ
gs-3960	77	17	the	the	DET
gs-3960	77	18	hurdles	hurdle	NOUN
gs-3960	77	19	that	that	PRON
gs-3960	77	20	must	must	AUX
gs-3960	77	21	be	be	AUX
gs-3960	77	22	overcome	overcome	VERB
gs-3960	77	23	to	to	PART
gs-3960	77	24	bring	bring	VERB
gs-3960	77	25	mitochondrial	mitochondrial	ADJ
gs-3960	77	26	-	-	PUNCT
gs-3960	77	27	targeted	target	VERB
gs-3960	77	28	therapies	therapy	NOUN
gs-3960	77	29	from	from	ADP
gs-3960	77	30	bench	bench	NOUN
gs-3960	77	31	to	to	ADP
gs-3960	77	32	bedside	bedside	NOUN
gs-3960	77	33	.	.	PUNCT
gs-3960	78	1	understanding	understanding	NOUN
gs-3960	78	2	provide	provide	VERB
gs-3960	78	3	insights	insight	NOUN
gs-3960	78	4	into	into	ADP
gs-3960	78	5	other	other	ADJ
gs-3960	78	6	neurodegenerative	neurodegenerative	ADJ
gs-3960	78	7	conditions	condition	NOUN
gs-3960	78	8	where	where	SCONJ
gs-3960	78	9	mitochondrial	mitochondrial	ADJ
gs-3960	78	10	impairment	impairment	NOUN
gs-3960	78	11	plays	play	VERB
gs-3960	78	12	a	a	DET
gs-3960	78	13	critical	critical	ADJ
gs-3960	78	14	role	role	NOUN
gs-3960	78	15	[	[	X
gs-3960	78	16	83	83	NUM
gs-3960	78	17	-	-	SYM
gs-3960	78	18	84	84	NUM
gs-3960	78	19	]	]	PUNCT
gs-3960	78	20	.	.	PUNCT
gs-3960	79	1	mitochondrial	mitochondrial	ADJ
gs-3960	79	2	dysfunction	dysfunction	NOUN
gs-3960	79	3	is	be	AUX
gs-3960	79	4	a	a	DET
gs-3960	79	5	common	common	ADJ
gs-3960	79	6	thread	thread	NOUN
gs-3960	79	7	in	in	ADP
gs-3960	79	8	aging	age	VERB
gs-3960	79	9	and	and	CCONJ
gs-3960	79	10	numerous	numerous	ADJ
gs-3960	79	11	neurological	neurological	ADJ
gs-3960	79	12	disorders	disorder	NOUN
gs-3960	79	13	.	.	PUNCT
gs-3960	80	1	by	by	ADP
gs-3960	80	2	elucidating	elucidate	VERB
gs-3960	80	3	the	the	DET
gs-3960	80	4	mechanisms	mechanism	NOUN
gs-3960	80	5	that	that	PRON
gs-3960	80	6	govern	govern	VERB
gs-3960	80	7	mitochondrial	mitochondrial	ADJ
gs-3960	80	8	quality	quality	NOUN
gs-3960	80	9	control	control	NOUN
gs-3960	80	10	and	and	CCONJ
gs-3960	80	11	metabolic	metabolic	NOUN
gs-3960	80	12	resilience	resilience	NOUN
gs-3960	80	13	,	,	PUNCT
gs-3960	80	14	scientists	scientist	NOUN
gs-3960	80	15	may	may	AUX
gs-3960	80	16	uncover	uncover	VERB
gs-3960	80	17	universal	universal	ADJ
gs-3960	80	18	principles	principle	NOUN
gs-3960	80	19	that	that	PRON
gs-3960	80	20	could	could	AUX
gs-3960	80	21	be	be	AUX
gs-3960	80	22	leveraged	leverage	VERB
gs-3960	80	23	to	to	PART
gs-3960	80	24	promote	promote	VERB
gs-3960	80	25	brain	brain	NOUN
gs-3960	80	26	health	health	NOUN
gs-3960	80	27	across	across	ADP
gs-3960	80	28	various	various	ADJ
gs-3960	80	29	conditions	condition	NOUN
gs-3960	80	30	.	.	PUNCT
gs-3960	81	1	the	the	DET
gs-3960	81	2	integration	integration	NOUN
gs-3960	81	3	of	of	ADP
gs-3960	81	4	genetic	genetic	ADJ
gs-3960	81	5	,	,	PUNCT
gs-3960	81	6	biochemical	biochemical	ADJ
gs-3960	81	7	,	,	PUNCT
gs-3960	81	8	and	and	CCONJ
gs-3960	81	9	clinical	clinical	ADJ
gs-3960	81	10	research	research	NOUN
gs-3960	81	11	will	will	AUX
gs-3960	81	12	be	be	AUX
gs-3960	81	13	essential	essential	ADJ
gs-3960	81	14	in	in	ADP
gs-3960	81	15	forging	forge	VERB
gs-3960	81	16	new	new	ADJ
gs-3960	81	17	paths	path	NOUN
gs-3960	81	18	toward	toward	ADP
gs-3960	81	19	effective	effective	ADJ
gs-3960	81	20	treatments	treatment	NOUN
gs-3960	81	21	,	,	PUNCT
gs-3960	81	22	neurodegenerative	neurodegenerative	ADJ
gs-3960	81	23	disorders	disorder	NOUN
gs-3960	81	24	[	[	X
gs-3960	81	25	85	85	NUM
gs-3960	81	26	]	]	PUNCT
gs-3960	81	27	.	.	PUNCT
gs-3960	82	1	the	the	DET
gs-3960	82	2	relationship	relationship	NOUN
gs-3960	82	3	between	between	ADP
gs-3960	82	4	mitochondrial	mitochondrial	ADJ
gs-3960	82	5	dysfunction	dysfunction	NOUN
gs-3960	82	6	,	,	PUNCT
gs-3960	82	7	impaired	impaired	ADJ
gs-3960	82	8	mitophagy	mitophagy	NOUN
gs-3960	82	9	,	,	PUNCT
gs-3960	82	10	and	and	CCONJ
gs-3960	82	11	connections	connection	NOUN
gs-3960	82	12	not	not	PART
gs-3960	82	13	only	only	ADV
gs-3960	82	14	deepens	deepen	VERB
gs-3960	82	15	our	our	PRON
gs-3960	82	16	understanding	understanding	NOUN
gs-3960	82	17	of	of	ADP
gs-3960	82	18	the	the	DET
gs-3960	82	19	disease	disease	NOUN
gs-3960	82	20	but	but	CCONJ
gs-3960	82	21	also	also	ADV
gs-3960	82	22	opens	open	VERB
gs-3960	82	23	new	new	ADJ
gs-3960	82	24	therapeutic	therapeutic	ADJ
gs-3960	82	25	possibilities	possibility	NOUN
gs-3960	82	26	.	.	PUNCT
gs-3960	83	1	as	as	SCONJ
gs-3960	83	2	research	research	NOUN
gs-3960	83	3	progresses	progress	NOUN
gs-3960	83	4	,	,	PUNCT
gs-3960	83	5	the	the	DET
gs-3960	83	6	hope	hope	NOUN
gs-3960	83	7	is	be	AUX
gs-3960	83	8	that	that	SCONJ
gs-3960	83	9	interventions	intervention	NOUN
gs-3960	83	10	targeting	target	VERB
gs-3960	83	11	these	these	DET
gs-3960	83	12	pathways	pathway	NOUN
gs-3960	83	13	will	will	AUX
gs-3960	83	14	move	move	VERB
gs-3960	83	15	beyond	beyond	ADP
gs-3960	83	16	preclinical	preclinical	ADJ
gs-3960	83	17	success	success	NOUN
gs-3960	83	18	into	into	ADP
gs-3960	83	19	meaningful	meaningful	ADJ
gs-3960	83	20	clinical	clinical	ADJ
gs-3960	83	21	applications	application	NOUN
gs-3960	83	22	,	,	PUNCT
gs-3960	83	23	offering	offer	VERB
gs-3960	83	24	tangible	tangible	ADJ
gs-3960	83	25	benefits	benefit	NOUN
gs-3960	83	26	for	for	ADP
gs-3960	83	27	patients	patient	NOUN
gs-3960	83	28	.	.	PUNCT
gs-3960	84	1	the	the	DET
gs-3960	84	2	journey	journey	NOUN
gs-3960	84	3	toward	toward	ADP
gs-3960	84	4	effective	effective	ADJ
gs-3960	84	5	treatments	treatment	NOUN
gs-3960	84	6	is	be	AUX
gs-3960	84	7	complex	complex	ADJ
gs-3960	84	8	,	,	PUNCT
gs-3960	84	9	but	but	CCONJ
gs-3960	84	10	with	with	ADP
gs-3960	84	11	continued	continue	VERB
gs-3960	84	12	exploration	exploration	NOUN
gs-3960	84	13	of	of	ADP
gs-3960	84	14	mitochondrial	mitochondrial	ADJ
gs-3960	84	15	biology	biology	NOUN
gs-3960	84	16	,	,	PUNCT
gs-3960	84	17	the	the	DET
gs-3960	84	18	potential	potential	NOUN
gs-3960	84	19	for	for	ADP
gs-3960	84	20	breakthroughs	breakthrough	NOUN
gs-3960	84	21	background	background	NOUN
gs-3960	84	22	neurodegenerative	neurodegenerative	ADJ
gs-3960	84	23	disorders	disorder	NOUN
gs-3960	84	24	,	,	PUNCT
gs-3960	84	25	characterized	characterize	VERB
gs-3960	84	26	by	by	ADP
gs-3960	84	27	the	the	DET
gs-3960	84	28	relentless	relentless	ADJ
gs-3960	84	29	degeneration	degeneration	NOUN
gs-3960	84	30	of	of	ADP
gs-3960	84	31	dopaminergic	dopaminergic	ADJ
gs-3960	84	32	neurons	neuron	NOUN
gs-3960	84	33	within	within	ADP
gs-3960	84	34	the	the	DET
gs-3960	84	35	substantia	substantia	NOUN
gs-3960	84	36	nigra	nigra	PROPN
gs-3960	84	37	pars	par	NOUN
gs-3960	84	38	compacta	compacta	NOUN
gs-3960	84	39	,	,	PUNCT
gs-3960	84	40	a	a	DET
gs-3960	84	41	region	region	NOUN
gs-3960	84	42	of	of	ADP
gs-3960	84	43	the	the	DET
gs-3960	84	44	brain	brain	NOUN
gs-3960	84	45	indispensable	indispensable	ADJ
gs-3960	84	46	for	for	ADP
gs-3960	84	47	of	of	ADP
gs-3960	84	48	these	these	DET
gs-3960	84	49	neurons	neuron	NOUN
gs-3960	84	50	have	have	AUX
gs-3960	84	51	already	already	ADV
gs-3960	84	52	been	be	AUX
gs-3960	84	53	lost	lose	VERB
gs-3960	84	54	,	,	PUNCT
gs-3960	84	55	underscoring	underscore	VERB
gs-3960	84	56	the	the	DET
gs-3960	84	57	silent	silent	ADJ
gs-3960	84	58	and	and	CCONJ
gs-3960	84	59	progressive	progressive	ADJ
gs-3960	84	60	nature	nature	NOUN
gs-3960	84	61	of	of	ADP
gs-3960	84	62	it	it	PRON
gs-3960	84	63	is	be	AUX
gs-3960	84	64	widely	widely	ADV
gs-3960	84	65	accepted	accept	VERB
gs-3960	84	66	that	that	SCONJ
gs-3960	84	67	a	a	DET
gs-3960	84	68	combination	combination	NOUN
gs-3960	84	69	of	of	ADP
gs-3960	84	70	genetic	genetic	ADJ
gs-3960	84	71	susceptibility	susceptibility	NOUN
gs-3960	84	72	and	and	CCONJ
gs-3960	84	73	environmental	environmental	ADJ
gs-3960	84	74	influences	influence	NOUN
gs-3960	84	75	conspire	conspire	VERB
gs-3960	84	76	to	to	PART
gs-3960	84	77	trigger	trigger	VERB
gs-3960	84	78	a	a	DET
gs-3960	84	79	cascade	cascade	NOUN
gs-3960	84	80	of	of	ADP
gs-3960	84	81	cellular	cellular	ADJ
gs-3960	84	82	disturbances	disturbance	NOUN
gs-3960	84	83	,	,	PUNCT
gs-3960	84	84	with	with	ADP
gs-3960	84	85	mitochondrial	mitochondrial	ADJ
gs-3960	84	86	dysfunction	dysfunction	NOUN
gs-3960	84	87	occupying	occupy	VERB
gs-3960	84	88	a	a	DET
gs-3960	84	89	central	central	ADJ
gs-3960	84	90	role	role	NOUN
gs-3960	84	91	in	in	ADP
gs-3960	84	92	disease	disease	NOUN
gs-3960	84	93	initiation	initiation	NOUN
gs-3960	84	94	and	and	CCONJ
gs-3960	84	95	progression	progression	NOUN
gs-3960	85	1	[	[	X
gs-3960	85	2	1,3,17	1,3,17	NUM
gs-3960	85	3	]	]	PUNCT
gs-3960	85	4	.	.	PUNCT
gs-3960	86	1	mitochondria	mitochondria	PROPN
gs-3960	86	2	,	,	PUNCT
gs-3960	86	3	often	often	ADV
gs-3960	86	4	referred	refer	VERB
gs-3960	86	5	to	to	ADP
gs-3960	86	6	as	as	ADP
gs-3960	86	7	the	the	DET
gs-3960	86	8	powerhouses	powerhouse	NOUN
gs-3960	86	9	of	of	ADP
gs-3960	86	10	the	the	DET
gs-3960	86	11	cell	cell	NOUN
gs-3960	86	12	,	,	PUNCT
gs-3960	86	13	are	be	AUX
gs-3960	86	14	essential	essential	ADJ
gs-3960	86	15	for	for	ADP
gs-3960	86	16	maintaining	maintain	VERB
gs-3960	86	17	neuronal	neuronal	ADJ
gs-3960	86	18	viability	viability	NOUN
gs-3960	86	19	through	through	ADP
gs-3960	86	20	their	their	PRON
gs-3960	86	21	roles	role	NOUN
gs-3960	86	22	in	in	ADP
gs-3960	86	23	energy	energy	NOUN
gs-3960	86	24	production	production	NOUN
gs-3960	86	25	,	,	PUNCT
gs-3960	86	26	calcium	calcium	NOUN
gs-3960	86	27	homeostasis	homeostasis	NOUN
gs-3960	86	28	,	,	PUNCT
gs-3960	86	29	and	and	CCONJ
gs-3960	86	30	the	the	DET
gs-3960	86	31	regulation	regulation	NOUN
gs-3960	86	32	of	of	ADP
gs-3960	86	33	apoptotic	apoptotic	ADJ
gs-3960	86	34	pathways	pathway	NOUN
gs-3960	86	35	.	.	PUNCT
gs-3960	87	1	these	these	DET
gs-3960	87	2	organelles	organelle	NOUN
gs-3960	87	3	are	be	AUX
gs-3960	87	4	particularly	particularly	ADV
gs-3960	87	5	vital	vital	ADJ
gs-3960	87	6	for	for	ADP
gs-3960	87	7	dopaminergic	dopaminergic	ADJ
gs-3960	87	8	neurons	neuron	NOUN
gs-3960	87	9	,	,	PUNCT
gs-3960	87	10	which	which	PRON
gs-3960	87	11	exhibit	exhibit	VERB
gs-3960	87	12	high	high	ADJ
gs-3960	87	13	metabolic	metabolic	NOUN
gs-3960	87	14	demands	demand	NOUN
gs-3960	87	15	due	due	ADP
gs-3960	87	16	to	to	ADP
gs-3960	87	17	their	their	PRON
gs-3960	87	18	extensive	extensive	ADJ
gs-3960	87	19	axonal	axonal	ADJ
gs-3960	87	20	arbors	arbor	NOUN
gs-3960	87	21	and	and	CCONJ
gs-3960	87	22	reliance	reliance	NOUN
gs-3960	87	23	on	on	ADP
gs-3960	87	24	precise	precise	ADJ
gs-3960	87	25	neurotransmitter	neurotransmitter	NOUN
gs-3960	87	26	release	release	NOUN
gs-3960	87	27	.	.	PUNCT
gs-3960	88	1	the	the	DET
gs-3960	88	2	vulnerability	vulnerability	NOUN
gs-3960	88	3	of	of	ADP
gs-3960	88	4	these	these	DET
gs-3960	88	5	neurons	neuron	NOUN
gs-3960	88	6	to	to	ADP
gs-3960	88	7	mitochondrial	mitochondrial	ADJ
gs-3960	88	8	impairment	impairment	NOUN
gs-3960	88	9	is	be	AUX
gs-3960	88	10	further	far	ADV
gs-3960	88	11	compounded	compound	VERB
gs-3960	88	12	by	by	ADP
gs-3960	88	13	their	their	PRON
gs-3960	88	14	inherent	inherent	ADJ
gs-3960	88	15	exposure	exposure	NOUN
gs-3960	88	16	to	to	ADP
gs-3960	88	17	oxidative	oxidative	ADJ
gs-3960	88	18	stress	stress	NOUN
gs-3960	88	19	,	,	PUNCT
gs-3960	88	20	a	a	DET
gs-3960	88	21	byproduct	byproduct	NOUN
gs-3960	88	22	of	of	ADP
gs-3960	88	23	dopamine	dopamine	NOUN
gs-3960	88	24	metabolism	metabolism	NOUN
gs-3960	88	25	itself	itself	PRON
gs-3960	88	26	.	.	PUNCT
gs-3960	89	1	when	when	SCONJ
gs-3960	89	2	georgian	georgian	PROPN
gs-3960	89	3	scientists/	scientists/	NUM
gs-3960	89	4	.	.	PUNCT
gs-3960	90	1	7	7	NUM
gs-3960	90	2	n	n	PRON
gs-3960	90	3	3	3	NUM
gs-3960	90	4	,	,	PUNCT
gs-3960	90	5	2025	2025	NUM
gs-3960	90	6	403	403	NUM
gs-3960	90	7	mitochondria	mitochondria	NOUN
gs-3960	90	8	fail	fail	VERB
gs-3960	90	9	to	to	PART
gs-3960	90	10	meet	meet	VERB
gs-3960	90	11	the	the	DET
gs-3960	90	12	energetic	energetic	ADJ
gs-3960	90	13	and	and	CCONJ
gs-3960	90	14	redox	redox	ADJ
gs-3960	90	15	demands	demand	NOUN
gs-3960	90	16	of	of	ADP
gs-3960	90	17	the	the	DET
gs-3960	90	18	cell	cell	NOUN
gs-3960	90	19	,	,	PUNCT
gs-3960	90	20	the	the	DET
gs-3960	90	21	consequences	consequence	NOUN
gs-3960	90	22	are	be	AUX
gs-3960	90	23	dire	dire	ADJ
gs-3960	90	24	:	:	PUNCT
gs-3960	90	25	bioenergetic	bioenergetic	ADJ
gs-3960	90	26	collapse	collapse	NOUN
gs-3960	90	27	,	,	PUNCT
gs-3960	90	28	oxidative	oxidative	ADJ
gs-3960	90	29	damage	damage	NOUN
gs-3960	90	30	,	,	PUNCT
gs-3960	90	31	and	and	CCONJ
gs-3960	90	32	ultimately	ultimately	ADV
gs-3960	90	33	,	,	PUNCT
gs-3960	90	34	neuronal	neuronal	ADJ
gs-3960	90	35	death	death	NOUN
gs-3960	91	1	[	[	X
gs-3960	91	2	2,5,27	2,5,27	NUM
gs-3960	91	3	]	]	PUNCT
gs-3960	91	4	.	.	PUNCT
gs-3960	92	1	disease	disease	NOUN
gs-3960	92	2	has	have	AUX
gs-3960	92	3	been	be	AUX
gs-3960	92	4	illuminated	illuminate	VERB
gs-3960	92	5	through	through	ADP
gs-3960	92	6	both	both	CCONJ
gs-3960	92	7	sporadic	sporadic	ADJ
gs-3960	92	8	and	and	CCONJ
gs-3960	92	9	familial	familial	ADJ
gs-3960	92	10	forms	form	NOUN
gs-3960	92	11	of	of	ADP
gs-3960	92	12	the	the	DET
gs-3960	92	13	disorder	disorder	NOUN
gs-3960	92	14	.	.	PUNCT
gs-3960	93	1	in	in	ADP
gs-3960	93	2	familial	familial	ADJ
gs-3960	93	3	cases	case	NOUN
gs-3960	93	4	,	,	PUNCT
gs-3960	93	5	mutations	mutation	NOUN
gs-3960	93	6	in	in	ADP
gs-3960	93	7	genes	gene	NOUN
gs-3960	93	8	such	such	ADJ
gs-3960	93	9	as	as	ADP
gs-3960	93	10	,	,	PUNCT
gs-3960	93	11	,	,	PUNCT
gs-3960	93	12	*	*	PUNCT
gs-3960	93	13	dj-1	dj-1	X
gs-3960	93	14	*	*	PUNCT
gs-3960	93	15	,	,	PUNCT
gs-3960	93	16	and	and	CCONJ
gs-3960	93	17	have	have	AUX
gs-3960	93	18	been	be	AUX
gs-3960	93	19	identified	identify	VERB
gs-3960	93	20	,	,	PUNCT
gs-3960	93	21	many	many	ADJ
gs-3960	93	22	of	of	ADP
gs-3960	93	23	which	which	PRON
gs-3960	93	24	are	be	AUX
gs-3960	93	25	intimately	intimately	ADV
gs-3960	93	26	involved	involve	VERB
gs-3960	93	27	in	in	ADP
gs-3960	93	28	mitochondrial	mitochondrial	ADJ
gs-3960	93	29	quality	quality	NOUN
gs-3960	93	30	control	control	NOUN
gs-3960	93	31	.	.	PUNCT
gs-3960	94	1	and	and	CCONJ
gs-3960	94	2	,	,	PUNCT
gs-3960	94	3	for	for	ADP
gs-3960	94	4	instance	instance	NOUN
gs-3960	94	5	,	,	PUNCT
gs-3960	94	6	are	be	AUX
gs-3960	94	7	critical	critical	ADJ
gs-3960	94	8	players	player	NOUN
gs-3960	94	9	in	in	ADP
gs-3960	94	10	the	the	DET
gs-3960	94	11	mitophagy	mitophagy	NOUN
gs-3960	94	12	pathway	pathway	NOUN
gs-3960	94	13	,	,	PUNCT
gs-3960	94	14	a	a	DET
gs-3960	94	15	selective	selective	ADJ
gs-3960	94	16	form	form	NOUN
gs-3960	94	17	of	of	ADP
gs-3960	94	18	autophagy	autophagy	NOUN
gs-3960	94	19	that	that	PRON
gs-3960	94	20	targets	target	VERB
gs-3960	94	21	damaged	damage	VERB
gs-3960	94	22	mitochondria	mitochondria	NOUN
gs-3960	94	23	for	for	ADP
gs-3960	94	24	degradation	degradation	NOUN
gs-3960	94	25	.	.	PUNCT
gs-3960	95	1	mutations	mutation	NOUN
gs-3960	95	2	in	in	ADP
gs-3960	95	3	these	these	DET
gs-3960	95	4	genes	gene	NOUN
gs-3960	95	5	disrupt	disrupt	VERB
gs-3960	95	6	the	the	DET
gs-3960	95	7	clearance	clearance	NOUN
gs-3960	95	8	of	of	ADP
gs-3960	95	9	dysfunctional	dysfunctional	ADJ
gs-3960	95	10	mitochondria	mitochondria	NOUN
gs-3960	95	11	,	,	PUNCT
gs-3960	95	12	leading	lead	VERB
gs-3960	95	13	to	to	ADP
gs-3960	95	14	their	their	PRON
gs-3960	95	15	accumulation	accumulation	NOUN
gs-3960	95	16	and	and	CCONJ
gs-3960	95	17	the	the	DET
gs-3960	95	18	subsequent	subsequent	ADJ
gs-3960	95	19	release	release	NOUN
gs-3960	95	20	of	of	ADP
gs-3960	95	21	reactive	reactive	ADJ
gs-3960	95	22	oxygen	oxygen	NOUN
gs-3960	95	23	species	specie	NOUN
gs-3960	95	24	that	that	PRON
gs-3960	95	25	inflict	inflict	VERB
gs-3960	95	26	widespread	widespread	ADJ
gs-3960	95	27	cellular	cellular	ADJ
gs-3960	95	28	damage	damage	NOUN
gs-3960	95	29	.	.	PUNCT
gs-3960	96	1	similarly	similarly	ADV
gs-3960	96	2	,	,	PUNCT
gs-3960	96	3	*	*	PUNCT
gs-3960	96	4	dj-1	dj-1	PROPN
gs-3960	96	5	*	*	VERB
gs-3960	96	6	plays	play	VERB
gs-3960	96	7	a	a	DET
gs-3960	96	8	role	role	NOUN
gs-3960	96	9	in	in	ADP
gs-3960	96	10	mitigating	mitigate	VERB
gs-3960	96	11	oxidative	oxidative	ADJ
gs-3960	96	12	stress	stress	NOUN
gs-3960	96	13	,	,	PUNCT
gs-3960	96	14	while	while	SCONJ
gs-3960	96	15	mutations	mutation	NOUN
gs-3960	96	16	have	have	AUX
gs-3960	96	17	been	be	AUX
gs-3960	96	18	linked	link	VERB
gs-3960	96	19	to	to	ADP
gs-3960	96	20	disturbances	disturbance	NOUN
gs-3960	96	21	in	in	ADP
gs-3960	96	22	mitochondrial	mitochondrial	ADJ
gs-3960	96	23	dynamics	dynamic	NOUN
gs-3960	96	24	and	and	CCONJ
gs-3960	96	25	autophagy	autophagy	NOUN
gs-3960	96	26	.	.	PUNCT
gs-3960	97	1	these	these	DET
gs-3960	97	2	genetic	genetic	ADJ
gs-3960	97	3	insights	insight	NOUN
gs-3960	97	4	have	have	AUX
gs-3960	97	5	not	not	PART
gs-3960	97	6	only	only	ADV
gs-3960	97	7	reinforced	reinforce	VERB
gs-3960	97	8	the	the	DET
gs-3960	97	9	centrality	centrality	NOUN
gs-3960	97	10	of	of	ADP
gs-3960	97	11	mitochondria	mitochondria	ADJ
gs-3960	97	12	underpinnings	underpinning	NOUN
gs-3960	97	13	of	of	ADP
gs-3960	97	14	neuronal	neuronal	ADJ
gs-3960	97	15	degeneration	degeneration	NOUN
gs-3960	97	16	[	[	X
gs-3960	97	17	4,8,16	4,8,16	NUM
gs-3960	97	18	]	]	PUNCT
gs-3960	97	19	.	.	PUNCT
gs-3960	98	1	symptoms	symptom	NOUN
gs-3960	98	2	in	in	ADP
gs-3960	98	3	animal	animal	NOUN
gs-3960	98	4	models	model	NOUN
gs-3960	98	5	,	,	PUNCT
gs-3960	98	6	further	far	ADV
gs-3960	98	7	cementing	cement	VERB
gs-3960	98	8	the	the	DET
gs-3960	98	9	connection	connection	NOUN
gs-3960	98	10	between	between	ADP
gs-3960	98	11	mitochondrial	mitochondrial	ADJ
gs-3960	98	12	impairment	impairment	NOUN
gs-3960	98	13	and	and	CCONJ
gs-3960	98	14	the	the	DET
gs-3960	98	15	disease	disease	NOUN
gs-3960	98	16	.	.	PUNCT
gs-3960	99	1	these	these	DET
gs-3960	99	2	toxins	toxin	NOUN
gs-3960	99	3	disrupt	disrupt	VERB
gs-3960	99	4	the	the	DET
gs-3960	99	5	electron	electron	NOUN
gs-3960	99	6	transport	transport	NOUN
gs-3960	99	7	chain	chain	NOUN
gs-3960	99	8	,	,	PUNCT
gs-3960	99	9	leading	lead	VERB
gs-3960	99	10	to	to	ADP
gs-3960	99	11	electron	electron	NOUN
gs-3960	99	12	leakage	leakage	NOUN
gs-3960	99	13	,	,	PUNCT
gs-3960	99	14	excessive	excessive	ADJ
gs-3960	99	15	reactive	reactive	ADJ
gs-3960	99	16	oxygen	oxygen	NOUN
gs-3960	99	17	species	species	NOUN
gs-3960	99	18	production	production	NOUN
gs-3960	99	19	,	,	PUNCT
gs-3960	99	20	and	and	CCONJ
gs-3960	99	21	eventual	eventual	ADJ
gs-3960	99	22	neuronal	neuronal	ADJ
gs-3960	99	23	death	death	NOUN
gs-3960	99	24	.	.	PUNCT
gs-3960	100	1	the	the	DET
gs-3960	100	2	selective	selective	ADJ
gs-3960	100	3	susceptibility	susceptibility	NOUN
gs-3960	100	4	of	of	ADP
gs-3960	100	5	dopaminergic	dopaminergic	ADJ
gs-3960	100	6	neurons	neuron	NOUN
gs-3960	100	7	to	to	ADP
gs-3960	100	8	these	these	DET
gs-3960	100	9	toxins	toxin	NOUN
gs-3960	100	10	highlights	highlight	VERB
gs-3960	100	11	the	the	DET
gs-3960	100	12	precarious	precarious	ADJ
gs-3960	100	13	balance	balance	NOUN
gs-3960	100	14	these	these	DET
gs-3960	100	15	cells	cell	NOUN
gs-3960	100	16	must	must	AUX
gs-3960	100	17	maintain	maintain	VERB
gs-3960	100	18	to	to	PART
gs-3960	100	19	survive	survive	VERB
gs-3960	100	20	,	,	PUNCT
gs-3960	100	21	a	a	DET
gs-3960	100	22	balance	balance	NOUN
gs-3960	100	23	that	that	PRON
gs-3960	100	24	is	be	AUX
gs-3960	100	25	easily	easily	ADV
gs-3960	100	26	tipped	tip	VERB
gs-3960	100	27	toward	toward	ADP
gs-3960	100	28	dysfunction	dysfunction	NOUN
gs-3960	100	29	in	in	ADP
gs-3960	100	30	the	the	DET
gs-3960	100	31	face	face	NOUN
gs-3960	100	32	of	of	ADP
gs-3960	100	33	mitochondrial	mitochondrial	ADJ
gs-3960	100	34	stress	stress	NOUN
gs-3960	100	35	[	[	X
gs-3960	100	36	11,24,77	11,24,77	NUM
gs-3960	100	37	]	]	PUNCT
gs-3960	100	38	.	.	PUNCT
gs-3960	101	1	one	one	NUM
gs-3960	101	2	of	of	ADP
gs-3960	101	3	the	the	DET
gs-3960	101	4	most	most	ADV
gs-3960	101	5	critical	critical	ADJ
gs-3960	101	6	processes	process	NOUN
gs-3960	101	7	governing	govern	VERB
gs-3960	101	8	mitochondrial	mitochondrial	ADJ
gs-3960	101	9	health	health	NOUN
gs-3960	101	10	is	be	AUX
gs-3960	101	11	mitophagy	mitophagy	ADJ
gs-3960	101	12	,	,	PUNCT
gs-3960	101	13	the	the	DET
gs-3960	101	14	selective	selective	ADJ
gs-3960	101	15	engulfment	engulfment	NOUN
gs-3960	101	16	and	and	CCONJ
gs-3960	101	17	degradation	degradation	NOUN
gs-3960	101	18	of	of	ADP
gs-3960	101	19	damaged	damage	VERB
gs-3960	101	20	mitochondria	mitochondria	NOUN
gs-3960	101	21	by	by	ADP
gs-3960	101	22	lysosomes	lysosome	NOUN
gs-3960	101	23	.	.	PUNCT
gs-3960	102	1	under	under	ADP
gs-3960	102	2	physiological	physiological	ADJ
gs-3960	102	3	conditions	condition	NOUN
gs-3960	102	4	,	,	PUNCT
gs-3960	102	5	mitophagy	mitophagy	NOUN
gs-3960	102	6	acts	act	VERB
gs-3960	102	7	as	as	ADP
gs-3960	102	8	a	a	DET
gs-3960	102	9	quality	quality	NOUN
gs-3960	102	10	control	control	NOUN
gs-3960	102	11	mechanism	mechanism	NOUN
gs-3960	102	12	,	,	PUNCT
gs-3960	102	13	ensuring	ensure	VERB
gs-3960	102	14	that	that	SCONJ
gs-3960	102	15	only	only	ADV
gs-3960	102	16	healthy	healthy	ADJ
gs-3960	102	17	mitochondria	mitochondria	NOUN
gs-3960	102	18	persist	persist	NOUN
gs-3960	102	19	within	within	ADP
gs-3960	102	20	the	the	DET
gs-3960	102	21	cell	cell	NOUN
gs-3960	102	22	.	.	PUNCT
gs-3960	103	1	the	the	DET
gs-3960	103	2	process	process	NOUN
gs-3960	103	3	is	be	AUX
gs-3960	103	4	initiated	initiate	VERB
gs-3960	103	5	by	by	ADP
gs-3960	103	6	the	the	DET
gs-3960	103	7	stabilization	stabilization	NOUN
gs-3960	103	8	of	of	ADP
gs-3960	103	9	pink1	pink1	NOUN
gs-3960	103	10	on	on	ADP
gs-3960	103	11	the	the	DET
gs-3960	103	12	outer	outer	ADJ
gs-3960	103	13	membrane	membrane	NOUN
gs-3960	103	14	of	of	ADP
gs-3960	103	15	depolarized	depolarized	ADJ
gs-3960	103	16	mitochondria	mitochondria	NOUN
gs-3960	103	17	,	,	PUNCT
gs-3960	103	18	which	which	PRON
gs-3960	103	19	in	in	ADP
gs-3960	103	20	turn	turn	NOUN
gs-3960	103	21	recruits	recruit	NOUN
gs-3960	103	22	and	and	CCONJ
gs-3960	103	23	activates	activate	VERB
gs-3960	103	24	parkin	parkin	NOUN
gs-3960	103	25	,	,	PUNCT
gs-3960	103	26	an	an	DET
gs-3960	103	27	e3	e3	NOUN
gs-3960	103	28	ubiquitin	ubiquitin	NOUN
gs-3960	103	29	ligase	ligase	NOUN
gs-3960	103	30	.	.	PUNCT
gs-3960	104	1	parkin	parkin	PROPN
gs-3960	104	2	ubiquitinates	ubiquitinate	NOUN
gs-3960	104	3	mitochondrial	mitochondrial	ADJ
gs-3960	104	4	proteins	protein	NOUN
gs-3960	104	5	,	,	PUNCT
gs-3960	104	6	however	however	ADV
gs-3960	104	7	,	,	PUNCT
gs-3960	104	8	mutations	mutation	NOUN
gs-3960	104	9	in	in	ADP
gs-3960	104	10	or	or	CCONJ
gs-3960	104	11	impair	impair	VERB
gs-3960	104	12	this	this	DET
gs-3960	104	13	process	process	NOUN
gs-3960	104	14	,	,	PUNCT
gs-3960	104	15	allowing	allow	VERB
gs-3960	104	16	defective	defective	ADJ
gs-3960	104	17	mitochondria	mitochondria	NOUN
gs-3960	104	18	to	to	PART
gs-3960	104	19	evade	evade	VERB
gs-3960	104	20	destruction	destruction	NOUN
gs-3960	104	21	.	.	PUNCT
gs-3960	105	1	the	the	DET
gs-3960	105	2	resulting	result	VERB
gs-3960	105	3	mitochondrial	mitochondrial	ADJ
gs-3960	105	4	dysfunction	dysfunction	NOUN
gs-3960	105	5	contributes	contribute	VERB
gs-3960	105	6	to	to	ADP
gs-3960	105	7	a	a	DET
gs-3960	105	8	vicious	vicious	ADJ
gs-3960	105	9	cycle	cycle	NOUN
gs-3960	105	10	of	of	ADP
gs-3960	105	11	oxidative	oxidative	ADJ
gs-3960	105	12	stress	stress	NOUN
gs-3960	105	13	,	,	PUNCT
gs-3960	105	14	energy	energy	NOUN
gs-3960	105	15	depletion	depletion	NOUN
gs-3960	105	16	,	,	PUNCT
gs-3960	105	17	and	and	CCONJ
gs-3960	105	18	neurodegeneration[5,13,28	neurodegeneration[5,13,28	NOUN
gs-3960	105	19	]	]	X
gs-3960	105	20	.	.	PUNCT
gs-3960	106	1	equally	equally	ADV
gs-3960	106	2	important	important	ADJ
gs-3960	106	3	in	in	ADP
gs-3960	106	4	the	the	DET
gs-3960	106	5	context	context	NOUN
gs-3960	106	6	of	of	ADP
gs-3960	106	7	mitochondrial	mitochondrial	ADJ
gs-3960	106	8	health	health	NOUN
gs-3960	106	9	is	be	AUX
gs-3960	106	10	the	the	DET
gs-3960	106	11	role	role	NOUN
gs-3960	106	12	of	of	ADP
gs-3960	106	13	nicotinamide	nicotinamide	NOUN
gs-3960	106	14	adenine	adenine	ADJ
gs-3960	106	15	dinucleotide	dinucleotide	NOUN
gs-3960	106	16	,	,	PUNCT
gs-3960	106	17	a	a	DET
gs-3960	106	18	pivotal	pivotal	ADJ
gs-3960	106	19	coenzyme	coenzyme	NOUN
gs-3960	106	20	involved	involve	VERB
gs-3960	106	21	in	in	ADP
gs-3960	106	22	redox	redox	ADJ
gs-3960	106	23	reactions	reaction	NOUN
gs-3960	106	24	,	,	PUNCT
gs-3960	106	25	energy	energy	NOUN
gs-3960	106	26	metabolism	metabolism	NOUN
gs-3960	106	27	,	,	PUNCT
gs-3960	106	28	and	and	CCONJ
gs-3960	106	29	dna	dna	PROPN
gs-3960	106	30	repair	repair	NOUN
gs-3960	106	31	.	.	PUNCT
gs-3960	107	1	nad+	nad+	NOUN
gs-3960	107	2	levels	level	NOUN
gs-3960	107	3	decline	decline	VERB
gs-3960	107	4	with	with	ADP
gs-3960	107	5	age	age	NOUN
gs-3960	107	6	,	,	PUNCT
gs-3960	107	7	a	a	DET
gs-3960	107	8	phenomenon	phenomenon	NOUN
gs-3960	107	9	that	that	PRON
gs-3960	107	10	has	have	AUX
gs-3960	107	11	been	be	AUX
gs-3960	107	12	implicated	implicate	VERB
gs-3960	107	13	in	in	ADP
gs-3960	107	14	nad+	nad+	PROPN
gs-3960	107	15	availability	availability	NOUN
gs-3960	107	16	compromises	compromise	VERB
gs-3960	107	17	the	the	DET
gs-3960	107	18	activity	activity	NOUN
gs-3960	107	19	of	of	ADP
gs-3960	107	20	sirtuins	sirtuin	NOUN
gs-3960	107	21	,	,	PUNCT
gs-3960	107	22	a	a	DET
gs-3960	107	23	family	family	NOUN
gs-3960	107	24	of	of	ADP
gs-3960	107	25	nad+-dependent	nad+-dependent	PROPN
gs-3960	107	26	deacylases	deacylase	NOUN
gs-3960	107	27	that	that	PRON
gs-3960	107	28	regulate	regulate	VERB
gs-3960	107	29	mitochondrial	mitochondrial	ADJ
gs-3960	107	30	biogenesis	biogenesis	NOUN
gs-3960	107	31	,	,	PUNCT
gs-3960	107	32	antioxidant	antioxidant	NOUN
gs-3960	107	33	defenses	defense	NOUN
gs-3960	107	34	,	,	PUNCT
gs-3960	107	35	and	and	CCONJ
gs-3960	107	36	inflammatory	inflammatory	ADJ
gs-3960	107	37	responses	response	NOUN
gs-3960	107	38	.	.	PUNCT
gs-3960	108	1	in	in	ADP
gs-3960	108	2	neurons	neuron	NOUN
gs-3960	108	3	,	,	PUNCT
gs-3960	108	4	diminished	diminish	VERB
gs-3960	108	5	nad+	nad+	PROPN
gs-3960	108	6	levels	level	NOUN
gs-3960	108	7	exacerbate	exacerbate	VERB
gs-3960	108	8	mitochondrial	mitochondrial	ADJ
gs-3960	108	9	dysfunction	dysfunction	NOUN
gs-3960	108	10	,	,	PUNCT
gs-3960	108	11	georgian	georgian	NOUN
gs-3960	108	12	scientists/	scientists/	NUM
gs-3960	108	13	.	.	PUNCT
gs-3960	109	1	7	7	NUM
gs-3960	109	2	n	n	PRON
gs-3960	109	3	3	3	NUM
gs-3960	109	4	,	,	PUNCT
gs-3960	109	5	2025	2025	NUM
gs-3960	109	6	404	404	NUM
gs-3960	109	7	preclinical	preclinical	ADJ
gs-3960	109	8	studies	study	NOUN
gs-3960	109	9	,	,	PUNCT
gs-3960	109	10	offering	offer	VERB
gs-3960	109	11	a	a	DET
gs-3960	109	12	potential	potential	ADJ
gs-3960	109	13	avenue	avenue	NOUN
gs-3960	109	14	for	for	ADP
gs-3960	109	15	therapeutic	therapeutic	ADJ
gs-3960	109	16	intervention	intervention	NOUN
gs-3960	110	1	[	[	X
gs-3960	110	2	7,24,75	7,24,75	NOUN
gs-3960	110	3	]	]	PUNCT
gs-3960	110	4	.	.	PUNCT
gs-3960	111	1	the	the	DET
gs-3960	111	2	interplay	interplay	NOUN
gs-3960	111	3	between	between	ADP
gs-3960	111	4	mitophagy	mitophagy	NOUN
gs-3960	111	5	and	and	CCONJ
gs-3960	111	6	nad+	nad+	PROPN
gs-3960	111	7	metabolism	metabolism	NOUN
gs-3960	111	8	represents	represent	VERB
gs-3960	111	9	a	a	DET
gs-3960	111	10	fascinating	fascinating	ADJ
gs-3960	111	11	ensures	ensure	NOUN
gs-3960	111	12	the	the	DET
gs-3960	111	13	removal	removal	NOUN
gs-3960	111	14	of	of	ADP
gs-3960	111	15	damaged	damage	VERB
gs-3960	111	16	mitochondria	mitochondria	NOUN
gs-3960	111	17	,	,	PUNCT
gs-3960	111	18	nad+	nad+	PROPN
gs-3960	111	19	supports	support	VERB
gs-3960	111	20	the	the	DET
gs-3960	111	21	function	function	NOUN
gs-3960	111	22	and	and	CCONJ
gs-3960	111	23	resilience	resilience	NOUN
gs-3960	111	24	of	of	ADP
gs-3960	111	25	those	those	PRON
gs-3960	111	26	that	that	PRON
gs-3960	111	27	remain	remain	VERB
gs-3960	111	28	.	.	PUNCT
gs-3960	112	1	together	together	ADV
gs-3960	112	2	,	,	PUNCT
gs-3960	112	3	these	these	DET
gs-3960	112	4	pathways	pathway	NOUN
gs-3960	112	5	influence	influence	VERB
gs-3960	112	6	critical	critical	ADJ
gs-3960	112	7	aspects	aspect	NOUN
gs-3960	112	8	of	of	ADP
gs-3960	112	9	cellular	cellular	ADJ
gs-3960	112	10	homeostasis	homeostasis	NOUN
gs-3960	112	11	,	,	PUNCT
gs-3960	112	12	from	from	ADP
gs-3960	112	13	energy	energy	NOUN
gs-3960	112	14	production	production	NOUN
gs-3960	112	15	to	to	ADP
gs-3960	112	16	the	the	DET
gs-3960	112	17	management	management	NOUN
gs-3960	112	18	of	of	ADP
gs-3960	112	19	oxidative	oxidative	ADJ
gs-3960	112	20	stress	stress	NOUN
gs-3960	112	21	.	.	PUNCT
gs-3960	113	1	disruptions	disruption	NOUN
gs-3960	113	2	in	in	ADP
gs-3960	113	3	either	either	DET
gs-3960	113	4	pathway	pathway	NOUN
gs-3960	113	5	can	can	AUX
gs-3960	113	6	tip	tip	VERB
gs-3960	113	7	the	the	DET
gs-3960	113	8	scales	scale	NOUN
gs-3960	113	9	toward	toward	ADP
gs-3960	113	10	neurodegeneration	neurodegeneration	NOUN
gs-3960	113	11	,	,	PUNCT
gs-3960	113	12	making	make	VERB
gs-3960	113	13	their	their	PRON
gs-3960	113	14	modulation	modulation	NOUN
gs-3960	113	15	an	an	DET
gs-3960	113	16	attractive	attractive	ADJ
gs-3960	113	17	strategy	strategy	NOUN
gs-3960	113	18	for	for	ADP
gs-3960	113	19	therapeutic	therapeutic	ADJ
gs-3960	113	20	development	development	NOUN
gs-3960	113	21	.	.	PUNCT
gs-3960	114	1	emerging	emerge	VERB
gs-3960	114	2	evidence	evidence	NOUN
gs-3960	114	3	suggests	suggest	VERB
gs-3960	114	4	that	that	SCONJ
gs-3960	114	5	enhancing	enhance	VERB
gs-3960	114	6	both	both	PRON
gs-3960	114	7	mitophagy	mitophagy	NOUN
gs-3960	114	8	and	and	CCONJ
gs-3960	114	9	nad+	nad+	PROPN
gs-3960	114	10	bioavailability	bioavailability	NOUN
gs-3960	114	11	may	may	AUX
gs-3960	114	12	have	have	VERB
gs-3960	114	13	synergistic	synergistic	ADJ
gs-3960	114	14	effects	effect	NOUN
gs-3960	114	15	,	,	PUNCT
gs-3960	114	16	potentially	potentially	ADV
gs-3960	114	17	offering	offer	VERB
gs-3960	114	18	greater	great	ADJ
gs-3960	114	19	neuroprotection	neuroprotection	NOUN
gs-3960	114	20	than	than	ADP
gs-3960	114	21	targeting	target	VERB
gs-3960	114	22	either	either	CCONJ
gs-3960	114	23	pathway	pathway	NOUN
gs-3960	114	24	alone	alone	ADV
gs-3960	114	25	[	[	X
gs-3960	114	26	8,12,21	8,12,21	NUM
gs-3960	114	27	]	]	PUNCT
gs-3960	114	28	.	.	PUNCT
gs-3960	115	1	despite	despite	SCONJ
gs-3960	115	2	these	these	DET
gs-3960	115	3	advances	advance	NOUN
gs-3960	115	4	,	,	PUNCT
gs-3960	115	5	significant	significant	ADJ
gs-3960	115	6	challenges	challenge	NOUN
gs-3960	115	7	remain	remain	VERB
gs-3960	115	8	in	in	ADP
gs-3960	115	9	translating	translate	VERB
gs-3960	115	10	preclinical	preclinical	ADJ
gs-3960	115	11	biology	biology	NOUN
gs-3960	115	12	,	,	PUNCT
gs-3960	115	13	the	the	DET
gs-3960	115	14	selective	selective	ADJ
gs-3960	115	15	vulnerability	vulnerability	NOUN
gs-3960	115	16	of	of	ADP
gs-3960	115	17	dopaminergic	dopaminergic	ADJ
gs-3960	115	18	neurons	neuron	NOUN
gs-3960	115	19	,	,	PUNCT
gs-3960	115	20	and	and	CCONJ
gs-3960	115	21	the	the	DET
gs-3960	115	22	progressive	progressive	ADJ
gs-3960	115	23	nature	nature	NOUN
gs-3960	115	24	of	of	ADP
gs-3960	115	25	the	the	DET
gs-3960	115	26	disease	disease	NOUN
gs-3960	115	27	all	all	PRON
gs-3960	115	28	pose	pose	VERB
gs-3960	115	29	formidable	formidable	ADJ
gs-3960	115	30	obstacles	obstacle	NOUN
gs-3960	115	31	.	.	PUNCT
gs-3960	116	1	moreover	moreover	ADV
gs-3960	116	2	,	,	PUNCT
gs-3960	116	3	the	the	DET
gs-3960	116	4	blood	blood	NOUN
gs-3960	116	5	-	-	PUNCT
gs-3960	116	6	brain	brain	NOUN
gs-3960	116	7	barrier	barrier	NOUN
gs-3960	116	8	restricts	restrict	VERB
gs-3960	116	9	the	the	DET
gs-3960	116	10	delivery	delivery	NOUN
gs-3960	116	11	of	of	ADP
gs-3960	116	12	many	many	ADJ
gs-3960	116	13	therapeutic	therapeutic	ADJ
gs-3960	116	14	compounds	compound	NOUN
gs-3960	116	15	to	to	ADP
gs-3960	116	16	the	the	DET
gs-3960	116	17	central	central	ADJ
gs-3960	116	18	nervous	nervous	ADJ
gs-3960	116	19	system	system	NOUN
gs-3960	116	20	,	,	PUNCT
gs-3960	116	21	complicating	complicate	VERB
gs-3960	116	22	drug	drug	NOUN
gs-3960	116	23	development	development	NOUN
gs-3960	116	24	efforts	effort	NOUN
gs-3960	116	25	.	.	PUNCT
gs-3960	117	1	current	current	ADJ
gs-3960	117	2	strategies	strategy	NOUN
gs-3960	117	3	under	under	ADP
gs-3960	117	4	investigation	investigation	NOUN
gs-3960	117	5	include	include	VERB
gs-3960	117	6	small	small	ADJ
gs-3960	117	7	molecules	molecule	NOUN
gs-3960	117	8	that	that	PRON
gs-3960	117	9	enhance	enhance	VERB
gs-3960	117	10	mitophagy	mitophagy	NOUN
gs-3960	117	11	,	,	PUNCT
gs-3960	117	12	nad+	nad+	PROPN
gs-3960	117	13	precursors	precursor	NOUN
gs-3960	117	14	,	,	PUNCT
gs-3960	117	15	and	and	CCONJ
gs-3960	117	16	compounds	compound	NOUN
gs-3960	117	17	that	that	PRON
gs-3960	117	18	improve	improve	VERB
gs-3960	117	19	mitochondrial	mitochondrial	ADJ
gs-3960	117	20	biogenesis	biogenesis	NOUN
gs-3960	117	21	.	.	PUNCT
gs-3960	118	1	additionally	additionally	ADV
gs-3960	118	2	,	,	PUNCT
gs-3960	118	3	non	non	ADJ
gs-3960	118	4	-	-	ADJ
gs-3960	118	5	pharmacological	pharmacological	ADJ
gs-3960	118	6	approaches	approach	NOUN
gs-3960	118	7	such	such	ADJ
gs-3960	118	8	as	as	ADP
gs-3960	118	9	exercise	exercise	NOUN
gs-3960	118	10	and	and	CCONJ
gs-3960	118	11	dietary	dietary	ADJ
gs-3960	118	12	interventions	intervention	NOUN
gs-3960	118	13	have	have	AUX
gs-3960	118	14	shown	show	VERB
gs-3960	118	15	potential	potential	NOUN
gs-3960	118	16	in	in	ADP
gs-3960	118	17	improving	improve	VERB
gs-3960	118	18	mitochondrial	mitochondrial	ADJ
gs-3960	118	19	function	function	NOUN
gs-3960	118	20	and	and	CCONJ
gs-3960	118	21	slowing	slow	VERB
gs-3960	118	22	disease	disease	NOUN
gs-3960	118	23	progression	progression	NOUN
gs-3960	118	24	,	,	PUNCT
gs-3960	118	25	highlighting	highlight	VERB
gs-3960	118	26	the	the	DET
gs-3960	118	27	importance	importance	NOUN
gs-3960	118	28	of	of	ADP
gs-3960	118	29	a	a	DET
gs-3960	118	30	multifaceted	multifaceted	ADJ
gs-3960	118	31	therapeutic	therapeutic	ADJ
gs-3960	118	32	approach	approach	NOUN
gs-3960	118	33	[	[	X
gs-3960	118	34	9,14,78	9,14,78	NUM
gs-3960	118	35	]	]	PUNCT
gs-3960	118	36	.	.	PUNCT
gs-3960	119	1	disease	disease	NOUN
gs-3960	119	2	represents	represent	VERB
gs-3960	119	3	one	one	NUM
gs-3960	119	4	of	of	ADP
gs-3960	119	5	the	the	DET
gs-3960	119	6	most	most	ADV
gs-3960	119	7	compelling	compelling	ADJ
gs-3960	119	8	narratives	narrative	NOUN
gs-3960	119	9	in	in	ADP
gs-3960	119	10	modern	modern	ADJ
gs-3960	119	11	neuroscience	neuroscience	NOUN
gs-3960	119	12	research	research	NOUN
gs-3960	119	13	.	.	PUNCT
gs-3960	120	1	this	this	DET
gs-3960	120	2	connection	connection	NOUN
gs-3960	120	3	,	,	PUNCT
gs-3960	120	4	first	first	ADV
gs-3960	120	5	suggested	suggest	VERB
gs-3960	120	6	by	by	ADP
gs-3960	120	7	the	the	DET
gs-3960	120	8	accidental	accidental	ADJ
gs-3960	120	9	discovery	discovery	NOUN
gs-3960	120	10	that	that	SCONJ
gs-3960	120	11	mitochondrial	mitochondrial	ADJ
gs-3960	120	12	toxins	toxin	NOUN
gs-3960	120	13	could	could	AUX
gs-3960	120	14	induce	induce	VERB
gs-3960	120	15	parkinsonian	parkinsonian	ADJ
gs-3960	120	16	symptoms	symptom	NOUN
gs-3960	120	17	in	in	ADP
gs-3960	120	18	humans	human	NOUN
gs-3960	120	19	,	,	PUNCT
gs-3960	120	20	has	have	AUX
gs-3960	120	21	evolved	evolve	VERB
gs-3960	120	22	into	into	ADP
gs-3960	120	23	a	a	DET
gs-3960	120	24	sophisticated	sophisticated	ADJ
gs-3960	120	25	understanding	understanding	NOUN
gs-3960	120	26	of	of	ADP
gs-3960	120	27	how	how	SCONJ
gs-3960	120	28	fundamental	fundamental	ADJ
gs-3960	120	29	cellular	cellular	ADJ
gs-3960	120	30	energetics	energetic	NOUN
gs-3960	120	31	govern	govern	VERB
gs-3960	120	32	neuronal	neuronal	ADJ
gs-3960	120	33	survival	survival	NOUN
gs-3960	120	34	.	.	PUNCT
gs-3960	121	1	the	the	DET
gs-3960	121	2	story	story	NOUN
gs-3960	121	3	of	of	ADP
gs-3960	121	4	the	the	DET
gs-3960	121	5	1980s	1980	NOUN
gs-3960	121	6	,	,	PUNCT
gs-3960	121	7	when	when	SCONJ
gs-3960	121	8	intravenous	intravenous	ADJ
gs-3960	121	9	drug	drug	NOUN
gs-3960	121	10	users	user	NOUN
gs-3960	121	11	in	in	ADP
gs-3960	121	12	california	california	PROPN
gs-3960	121	13	developed	develop	VERB
gs-3960	121	14	severe	severe	ADJ
gs-3960	121	15	parkinsonism	parkinsonism	NOUN
gs-3960	121	16	after	after	ADP
gs-3960	121	17	injecting	inject	VERB
gs-3960	121	18	a	a	DET
gs-3960	121	19	synthetic	synthetic	ADJ
gs-3960	121	20	heroin	heroin	NOUN
gs-3960	121	21	contaminated	contaminate	VERB
gs-3960	121	22	with	with	ADP
gs-3960	121	23	mptp	mptp	PROPN
gs-3960	121	24	.	.	PUNCT
gs-3960	122	1	this	this	DET
gs-3960	122	2	compound	compound	NOUN
gs-3960	122	3	was	be	AUX
gs-3960	122	4	later	later	ADV
gs-3960	122	5	found	find	VERB
gs-3960	122	6	to	to	PART
gs-3960	122	7	specifically	specifically	ADV
gs-3960	122	8	target	target	VERB
gs-3960	122	9	mitochondrial	mitochondrial	ADJ
gs-3960	122	10	complex	complex	NOUN
gs-3960	122	11	i	i	PRON
gs-3960	122	12	in	in	ADP
gs-3960	122	13	dopaminergic	dopaminergic	ADJ
gs-3960	122	14	neurons	neuron	NOUN
gs-3960	122	15	,	,	PUNCT
gs-3960	122	16	providing	provide	VERB
gs-3960	122	17	the	the	DET
gs-3960	122	18	first	first	ADJ
gs-3960	122	19	direct	direct	ADJ
gs-3960	122	20	evidence	evidence	NOUN
gs-3960	122	21	that	that	SCONJ
gs-3960	122	22	mitochondrial	mitochondrial	ADJ
gs-3960	122	23	impairment	impairment	NOUN
gs-3960	122	24	could	could	AUX
gs-3960	122	25	selectively	selectively	ADV
gs-3960	122	26	destroy	destroy	VERB
gs-3960	122	27	the	the	DET
gs-3960	122	28	very	very	ADJ
gs-3960	122	29	neurons	neuron	NOUN
gs-3960	122	30	at	at	ADP
gs-3960	122	31	the	the	DET
gs-3960	122	32	cellular	cellular	ADJ
gs-3960	122	33	level	level	NOUN
gs-3960	122	34	,	,	PUNCT
gs-3960	122	35	the	the	DET
gs-3960	122	36	substantia	substantia	NOUN
gs-3960	122	37	nigra	nigra	PROPN
gs-3960	122	38	pars	par	NOUN
gs-3960	122	39	compacta	compacta	NOUN
gs-3960	122	40	represents	represent	VERB
gs-3960	122	41	one	one	NUM
gs-3960	122	42	of	of	ADP
gs-3960	122	43	the	the	DET
gs-3960	122	44	most	most	ADV
gs-3960	122	45	metabolically	metabolically	ADV
gs-3960	122	46	demanding	demand	VERB
gs-3960	122	47	regions	region	NOUN
gs-3960	122	48	of	of	ADP
gs-3960	122	49	the	the	DET
gs-3960	122	50	brain	brain	NOUN
gs-3960	122	51	.	.	PUNCT
gs-3960	123	1	dopaminergic	dopaminergic	ADJ
gs-3960	123	2	neurons	neuron	NOUN
gs-3960	123	3	in	in	ADP
gs-3960	123	4	this	this	DET
gs-3960	123	5	area	area	NOUN
gs-3960	123	6	maintain	maintain	VERB
gs-3960	123	7	extraordinarily	extraordinarily	ADV
gs-3960	123	8	extensive	extensive	ADJ
gs-3960	123	9	axonal	axonal	ADJ
gs-3960	123	10	arbors	arbor	NOUN
gs-3960	123	11	,	,	PUNCT
gs-3960	123	12	with	with	ADP
gs-3960	123	13	single	single	ADJ
gs-3960	123	14	neurons	neuron	NOUN
gs-3960	123	15	establishing	establish	VERB
gs-3960	123	16	up	up	ADP
gs-3960	123	17	to	to	PART
gs-3960	123	18	half	half	DET
gs-3960	123	19	a	a	DET
gs-3960	123	20	million	million	NUM
gs-3960	123	21	synapses	synapsis	NOUN
gs-3960	123	22	throughout	throughout	ADP
gs-3960	123	23	the	the	DET
gs-3960	123	24	striatum	striatum	NOUN
gs-3960	123	25	.	.	PUNCT
gs-3960	124	1	this	this	DET
gs-3960	124	2	remarkable	remarkable	ADJ
gs-3960	124	3	connectivity	connectivity	NOUN
gs-3960	124	4	comes	come	VERB
gs-3960	124	5	at	at	ADP
gs-3960	124	6	an	an	DET
gs-3960	124	7	enormous	enormous	ADJ
gs-3960	124	8	energetic	energetic	ADJ
gs-3960	124	9	cost	cost	NOUN
gs-3960	124	10	,	,	PUNCT
gs-3960	124	11	requiring	require	VERB
gs-3960	124	12	continuous	continuous	ADJ
gs-3960	124	13	atp	atp	NOUN
gs-3960	124	14	production	production	NOUN
gs-3960	124	15	to	to	PART
gs-3960	124	16	maintain	maintain	VERB
gs-3960	124	17	membrane	membrane	NOUN
gs-3960	124	18	potentials	potential	NOUN
gs-3960	124	19	,	,	PUNCT
gs-3960	124	20	georgian	georgian	NOUN
gs-3960	124	21	scientists/	scientists/	NUM
gs-3960	124	22	.	.	PUNCT
gs-3960	125	1	7	7	NUM
gs-3960	125	2	n	n	PRON
gs-3960	125	3	3	3	NUM
gs-3960	125	4	,	,	PUNCT
gs-3960	125	5	2025	2025	NUM
gs-3960	125	6	405	405	NUM
gs-3960	125	7	vesicular	vesicular	ADJ
gs-3960	125	8	dopamine	dopamine	NOUN
gs-3960	125	9	packaging	packaging	NOUN
gs-3960	125	10	,	,	PUNCT
gs-3960	125	11	and	and	CCONJ
gs-3960	125	12	calcium	calcium	NOUN
gs-3960	125	13	homeostasis	homeostasis	NOUN
gs-3960	125	14	.	.	PUNCT
gs-3960	126	1	the	the	DET
gs-3960	126	2	neurons	neuron	NOUN
gs-3960	126	3	accomplish	accomplish	VERB
gs-3960	126	4	this	this	DET
gs-3960	126	5	feat	feat	NOUN
gs-3960	126	6	through	through	ADP
gs-3960	126	7	dense	dense	ADJ
gs-3960	126	8	mitochondrial	mitochondrial	ADJ
gs-3960	126	9	networks	network	NOUN
gs-3960	126	10	that	that	PRON
gs-3960	126	11	must	must	AUX
gs-3960	126	12	constantly	constantly	ADV
gs-3960	126	13	adapt	adapt	VERB
gs-3960	126	14	to	to	ADP
gs-3960	126	15	fluctuating	fluctuate	VERB
gs-3960	126	16	energy	energy	NOUN
gs-3960	126	17	demands	demand	NOUN
gs-3960	126	18	.	.	PUNCT
gs-3960	127	1	however	however	ADV
gs-3960	127	2	,	,	PUNCT
gs-3960	127	3	this	this	DET
gs-3960	127	4	same	same	ADJ
gs-3960	127	5	specialization	specialization	NOUN
gs-3960	127	6	makes	make	VERB
gs-3960	127	7	nigral	nigral	ADJ
gs-3960	127	8	neurons	neuron	NOUN
gs-3960	127	9	particularly	particularly	ADV
gs-3960	127	10	vulnerable	vulnerable	ADJ
gs-3960	127	11	to	to	ADP
gs-3960	127	12	mitochondrial	mitochondrial	ADJ
gs-3960	127	13	disturbances	disturbance	NOUN
gs-3960	127	14	.	.	PUNCT
gs-3960	128	1	the	the	DET
gs-3960	128	2	situation	situation	NOUN
gs-3960	128	3	is	be	AUX
gs-3960	128	4	further	far	ADV
gs-3960	128	5	complicated	complicate	VERB
gs-3960	128	6	by	by	ADP
gs-3960	128	7	the	the	DET
gs-3960	128	8	oxidative	oxidative	ADJ
gs-3960	128	9	stress	stress	NOUN
gs-3960	128	10	inherent	inherent	ADJ
gs-3960	128	11	to	to	PART
gs-3960	128	12	dopamine	dopamine	VERB
gs-3960	128	13	metabolism	metabolism	NOUN
gs-3960	128	14	itself	itself	PRON
gs-3960	128	15	.	.	PUNCT
gs-3960	129	1	the	the	DET
gs-3960	129	2	enzymatic	enzymatic	ADJ
gs-3960	129	3	breakdown	breakdown	NOUN
gs-3960	129	4	of	of	ADP
gs-3960	129	5	dopamine	dopamine	NOUN
gs-3960	129	6	by	by	ADP
gs-3960	129	7	monoamine	monoamine	ADJ
gs-3960	129	8	oxidase	oxidase	NOUN
gs-3960	129	9	generates	generate	VERB
gs-3960	129	10	hydrogen	hydrogen	NOUN
gs-3960	129	11	peroxide	peroxide	NOUN
gs-3960	129	12	,	,	PUNCT
gs-3960	129	13	while	while	SCONJ
gs-3960	129	14	spontaneous	spontaneous	ADJ
gs-3960	129	15	dopamine	dopamine	NOUN
gs-3960	129	16	oxidation	oxidation	NOUN
gs-3960	129	17	produces	produce	VERB
gs-3960	129	18	reactive	reactive	ADJ
gs-3960	129	19	quinones	quinone	NOUN
gs-3960	129	20	,	,	PUNCT
gs-3960	129	21	together	together	ADV
gs-3960	129	22	creating	create	VERB
gs-3960	129	23	a	a	DET
gs-3960	129	24	pro	pro	ADJ
gs-3960	129	25	-	-	ADJ
gs-3960	129	26	oxidant	oxidant	ADJ
gs-3960	129	27	environment	environment	NOUN
gs-3960	129	28	that	that	PRON
gs-3960	129	29	challenges	challenge	VERB
gs-3960	129	30	mitochondrial	mitochondrial	ADJ
gs-3960	129	31	antioxidant	antioxidant	NOUN
gs-3960	129	32	defenses	defense	NOUN
gs-3960	129	33	[	[	X
gs-3960	129	34	11,14,20	11,14,20	NUM
gs-3960	129	35	]	]	PUNCT
gs-3960	129	36	.	.	PUNCT
gs-3960	130	1	mitochondrial	mitochondrial	ADJ
gs-3960	130	2	pathophysiology	pathophysiology	NOUN
gs-3960	130	3	.	.	PUNCT
gs-3960	131	1	the	the	DET
gs-3960	131	2	discovery	discovery	NOUN
gs-3960	131	3	that	that	PRON
gs-3960	131	4	mutations	mutation	NOUN
gs-3960	131	5	in	in	ADP
gs-3960	131	6	the	the	DET
gs-3960	131	7	park2	park2	NOUN
gs-3960	131	8	gene	gene	NOUN
gs-3960	131	9	encoding	encode	VERB
gs-3960	131	10	parkin	parkin	NOUN
gs-3960	131	11	and	and	CCONJ
gs-3960	131	12	park6	park6	NOUN
gs-3960	131	13	encoding	encoding	NOUN
gs-3960	131	14	pink1	pink1	NOUN
gs-3960	131	15	cause	cause	VERB
gs-3960	131	16	autosomal	autosomal	ADJ
gs-3960	131	17	recessive	recessive	ADJ
gs-3960	131	18	parkinsonism	parkinsonism	NOUN
gs-3960	131	19	revealed	reveal	VERB
gs-3960	131	20	that	that	SCONJ
gs-3960	131	21	proper	proper	ADJ
gs-3960	131	22	mitochondrial	mitochondrial	ADJ
gs-3960	131	23	quality	quality	NOUN
gs-3960	131	24	control	control	NOUN
gs-3960	131	25	is	be	AUX
gs-3960	131	26	not	not	PART
gs-3960	131	27	merely	merely	ADV
gs-3960	131	28	important	important	ADJ
gs-3960	131	29	but	but	CCONJ
gs-3960	131	30	essential	essential	ADJ
gs-3960	131	31	for	for	ADP
gs-3960	131	32	dopaminergic	dopaminergic	ADJ
gs-3960	131	33	neuron	neuron	NOUN
gs-3960	131	34	survival	survival	NOUN
gs-3960	131	35	.	.	PUNCT
gs-3960	132	1	these	these	DET
gs-3960	132	2	proteins	protein	NOUN
gs-3960	132	3	form	form	VERB
gs-3960	132	4	the	the	DET
gs-3960	132	5	core	core	NOUN
gs-3960	132	6	of	of	ADP
gs-3960	132	7	a	a	DET
gs-3960	132	8	sophisticated	sophisticated	ADJ
gs-3960	132	9	surveillance	surveillance	NOUN
gs-3960	132	10	system	system	NOUN
gs-3960	132	11	that	that	PRON
gs-3960	132	12	identifies	identify	VERB
gs-3960	132	13	and	and	CCONJ
gs-3960	132	14	eliminates	eliminate	VERB
gs-3960	132	15	damaged	damage	VERB
gs-3960	132	16	mitochondria	mitochondria	NOUN
gs-3960	132	17	through	through	ADP
gs-3960	132	18	mitophagy	mitophagy	NOUN
gs-3960	132	19	.	.	PUNCT
gs-3960	133	1	the	the	DET
gs-3960	133	2	current	current	ADJ
gs-3960	133	3	model	model	NOUN
gs-3960	133	4	suggests	suggest	VERB
gs-3960	133	5	that	that	SCONJ
gs-3960	133	6	mitochondrial	mitochondrial	ADJ
gs-3960	133	7	depolarization	depolarization	NOUN
gs-3960	133	8	leads	lead	VERB
gs-3960	133	9	to	to	ADP
gs-3960	133	10	pink1	pink1	NOUN
gs-3960	133	11	accumulation	accumulation	NOUN
gs-3960	133	12	on	on	ADP
gs-3960	133	13	the	the	DET
gs-3960	133	14	outer	outer	ADJ
gs-3960	133	15	mitochondrial	mitochondrial	ADJ
gs-3960	133	16	membrane	membrane	NOUN
gs-3960	133	17	,	,	PUNCT
gs-3960	133	18	where	where	SCONJ
gs-3960	133	19	it	it	PRON
gs-3960	133	20	phosphorylates	phosphorylate	VERB
gs-3960	133	21	both	both	DET
gs-3960	133	22	ubiquitin	ubiquitin	NOUN
gs-3960	133	23	and	and	CCONJ
gs-3960	133	24	parkin	parkin	ADJ
gs-3960	133	25	,	,	PUNCT
gs-3960	133	26	initiating	initiate	VERB
gs-3960	133	27	a	a	DET
gs-3960	133	28	signaling	signal	VERB
gs-3960	133	29	cascade	cascade	NOUN
gs-3960	133	30	that	that	PRON
gs-3960	133	31	ultimately	ultimately	ADV
gs-3960	133	32	results	result	VERB
gs-3960	133	33	in	in	ADP
gs-3960	133	34	autophagic	autophagic	ADJ
gs-3960	133	35	engulfment	engulfment	NOUN
gs-3960	133	36	of	of	ADP
gs-3960	133	37	the	the	DET
gs-3960	133	38	damaged	damage	VERB
gs-3960	133	39	control	control	NOUN
gs-3960	133	40	mechanism	mechanism	NOUN
gs-3960	133	41	fails	fail	VERB
gs-3960	133	42	,	,	PUNCT
gs-3960	133	43	allowing	allow	VERB
gs-3960	133	44	dysfunctional	dysfunctional	ADJ
gs-3960	133	45	mitochondria	mitochondria	NOUN
gs-3960	133	46	to	to	PART
gs-3960	133	47	persist	persist	VERB
gs-3960	133	48	and	and	CCONJ
gs-3960	133	49	propagate	propagate	VERB
gs-3960	133	50	oxidative	oxidative	ADJ
gs-3960	133	51	damage	damage	NOUN
gs-3960	133	52	throughout	throughout	ADP
gs-3960	133	53	the	the	DET
gs-3960	133	54	cell	cell	NOUN
gs-3960	133	55	[	[	X
gs-3960	133	56	12,15,17	12,15,17	NUM
gs-3960	133	57	]	]	PUNCT
gs-3960	133	58	.	.	PUNCT
gs-3960	134	1	mfn1/2	mfn1/2	PROPN
gs-3960	134	2	and	and	CCONJ
gs-3960	134	3	opa1	opa1	PROPN
gs-3960	134	4	,	,	PUNCT
gs-3960	134	5	allows	allow	VERB
gs-3960	134	6	mitochondria	mitochondria	PROPN
gs-3960	134	7	to	to	PART
gs-3960	134	8	share	share	VERB
gs-3960	134	9	components	component	NOUN
gs-3960	134	10	and	and	CCONJ
gs-3960	134	11	dilute	dilute	VERB
gs-3960	134	12	damage	damage	NOUN
gs-3960	134	13	,	,	PUNCT
gs-3960	134	14	while	while	SCONJ
gs-3960	134	15	fission	fission	NOUN
gs-3960	134	16	,	,	PUNCT
gs-3960	134	17	driven	drive	VERB
gs-3960	134	18	by	by	ADP
gs-3960	134	19	drp1	drp1	PROPN
gs-3960	134	20	,	,	PUNCT
gs-3960	134	21	facilitates	facilitate	VERB
gs-3960	134	22	the	the	DET
gs-3960	134	23	segregation	segregation	NOUN
gs-3960	134	24	of	of	ADP
gs-3960	134	25	damaged	damage	VERB
gs-3960	134	26	segments	segment	NOUN
gs-3960	134	27	for	for	ADP
gs-3960	134	28	removal	removal	NOUN
gs-3960	134	29	.	.	PUNCT
gs-3960	135	1	in	in	ADP
gs-3960	135	2	fission	fission	NOUN
gs-3960	135	3	and	and	CCONJ
gs-3960	135	4	fragmented	fragmented	ADJ
gs-3960	135	5	mitochondrial	mitochondrial	ADJ
gs-3960	135	6	networks	network	NOUN
gs-3960	135	7	in	in	ADP
gs-3960	135	8	patient	patient	NOUN
gs-3960	135	9	-	-	PUNCT
gs-3960	135	10	derived	derive	VERB
gs-3960	135	11	neurons	neuron	NOUN
gs-3960	135	12	.	.	PUNCT
gs-3960	136	1	the	the	DET
gs-3960	136	2	pdassociated	pdassociate	VERB
gs-3960	136	3	protein	protein	NOUN
gs-3960	136	4	lrrk2	lrrk2	NOUN
gs-3960	136	5	appears	appear	VERB
gs-3960	136	6	to	to	PART
gs-3960	136	7	regulate	regulate	VERB
gs-3960	136	8	these	these	DET
gs-3960	136	9	processes	process	NOUN
gs-3960	136	10	through	through	ADP
gs-3960	136	11	phosphorylation	phosphorylation	NOUN
gs-3960	136	12	of	of	ADP
gs-3960	136	13	mitochondrial	mitochondrial	ADJ
gs-3960	136	14	rabs	rab	NOUN
gs-3960	136	15	,	,	PUNCT
gs-3960	136	16	while	while	SCONJ
gs-3960	136	17	alpha	alpha	NOUN
gs-3960	136	18	-	-	PUNCT
gs-3960	136	19	synuclein	synuclein	NOUN
gs-3960	136	20	aggregates	aggregate	NOUN
gs-3960	136	21	can	can	AUX
gs-3960	136	22	directly	directly	ADV
gs-3960	136	23	impair	impair	VERB
gs-3960	136	24	mitochondrial	mitochondrial	ADJ
gs-3960	136	25	fusion	fusion	NOUN
gs-3960	136	26	.	.	PUNCT
gs-3960	137	1	these	these	DET
gs-3960	137	2	disturbances	disturbance	NOUN
gs-3960	137	3	in	in	ADP
gs-3960	137	4	dynamics	dynamic	NOUN
gs-3960	137	5	not	not	PART
gs-3960	137	6	only	only	ADV
gs-3960	137	7	compromise	compromise	VERB
gs-3960	137	8	energy	energy	NOUN
gs-3960	137	9	production	production	NOUN
gs-3960	137	10	but	but	CCONJ
gs-3960	137	11	also	also	ADV
gs-3960	137	12	disrupt	disrupt	VERB
gs-3960	137	13	mitochondrial	mitochondrial	ADJ
gs-3960	137	14	trafficking	trafficking	NOUN
gs-3960	137	15	along	along	ADP
gs-3960	137	16	axons	axon	NOUN
gs-3960	137	17	,	,	PUNCT
gs-3960	137	18	creating	create	VERB
gs-3960	137	19	local	local	ADJ
gs-3960	137	20	energy	energy	NOUN
gs-3960	137	21	crises	crisis	NOUN
gs-3960	137	22	in	in	ADP
gs-3960	137	23	distal	distal	ADJ
gs-3960	137	24	synaptic	synaptic	ADJ
gs-3960	137	25	terminals	terminal	NOUN
gs-3960	137	26	that	that	PRON
gs-3960	137	27	may	may	AUX
gs-3960	137	28	contribute	contribute	VERB
gs-3960	137	29	to	to	ADP
gs-3960	137	30	the	the	DET
gs-3960	137	31	dying	die	VERB
gs-3960	137	32	-	-	PUNCT
gs-3960	137	33	back	back	NOUN
gs-3960	137	34	neurodegeneration	neurodegeneration	NOUN
gs-3960	137	35	observed	observe	VERB
gs-3960	137	36	in	in	ADP
gs-3960	137	37	the	the	DET
gs-3960	137	38	interface	interface	NOUN
gs-3960	137	39	between	between	ADP
gs-3960	137	40	mitochondria	mitochondria	NOUN
gs-3960	137	41	and	and	CCONJ
gs-3960	137	42	cellular	cellular	ADJ
gs-3960	137	43	calcium	calcium	NOUN
gs-3960	137	44	homeostasis	homeostasis	NOUN
gs-3960	137	45	presents	present	NOUN
gs-3960	137	46	mitochondrial	mitochondrial	ADJ
gs-3960	137	47	calcium	calcium	NOUN
gs-3960	137	48	buffering	buffering	NOUN
gs-3960	137	49	to	to	PART
gs-3960	137	50	handle	handle	VERB
gs-3960	137	51	activity	activity	NOUN
gs-3960	137	52	-	-	PUNCT
gs-3960	137	53	dependent	dependent	ADJ
gs-3960	137	54	calcium	calcium	NOUN
gs-3960	137	55	loads	load	NOUN
gs-3960	137	56	,	,	PUNCT
gs-3960	137	57	particularly	particularly	ADV
gs-3960	137	58	through	through	ADP
gs-3960	137	59	l	l	ADJ
gs-3960	137	60	-	-	PUNCT
gs-3960	137	61	type	type	NOUN
gs-3960	137	62	calcium	calcium	NOUN
gs-3960	137	63	channels	channel	NOUN
gs-3960	137	64	that	that	PRON
gs-3960	137	65	are	be	AUX
gs-3960	137	66	unusually	unusually	ADV
gs-3960	137	67	highly	highly	ADV
gs-3960	137	68	expressed	express	VERB
gs-3960	137	69	in	in	ADP
gs-3960	137	70	these	these	DET
gs-3960	137	71	cells	cell	NOUN
gs-3960	137	72	.	.	PUNCT
gs-3960	138	1	when	when	SCONJ
gs-3960	138	2	dysfunction	dysfunction	NOUN
gs-3960	138	3	,	,	PUNCT
gs-3960	138	4	membrane	membrane	NOUN
gs-3960	138	5	depolarization	depolarization	NOUN
gs-3960	138	6	,	,	PUNCT
gs-3960	138	7	or	or	CCONJ
gs-3960	138	8	opening	opening	NOUN
gs-3960	138	9	of	of	ADP
gs-3960	138	10	the	the	DET
gs-3960	138	11	mitochondrial	mitochondrial	ADJ
gs-3960	138	12	permeability	permeability	NOUN
gs-3960	138	13	pathways	pathway	NOUN
gs-3960	138	14	.	.	PUNCT
gs-3960	139	1	recent	recent	ADJ
gs-3960	139	2	work	work	NOUN
gs-3960	139	3	has	have	AUX
gs-3960	139	4	shown	show	VERB
gs-3960	139	5	that	that	SCONJ
gs-3960	139	6	alpha	alpha	NOUN
gs-3960	139	7	-	-	PUNCT
gs-3960	139	8	synuclein	synuclein	NOUN
gs-3960	139	9	oligomers	oligomer	NOUN
gs-3960	139	10	can	can	AUX
gs-3960	139	11	directly	directly	ADV
gs-3960	139	12	georgian	georgian	VERB
gs-3960	139	13	scientists/	scientists/	NUM
gs-3960	139	14	.	.	PUNCT
gs-3960	140	1	7	7	NUM
gs-3960	140	2	n	n	PRON
gs-3960	140	3	3	3	NUM
gs-3960	140	4	,	,	PUNCT
gs-3960	140	5	2025	2025	NUM
gs-3960	140	6	406	406	NUM
gs-3960	140	7	permeabilize	permeabilize	NOUN
gs-3960	140	8	mitochondrial	mitochondrial	ADJ
gs-3960	140	9	membranes	membrane	NOUN
gs-3960	140	10	,	,	PUNCT
gs-3960	140	11	exacerbating	exacerbate	VERB
gs-3960	140	12	calcium	calcium	NOUN
gs-3960	140	13	dyshomeostasis	dyshomeostasis	NOUN
gs-3960	140	14	.	.	PUNCT
gs-3960	141	1	this	this	DET
gs-3960	141	2	intersection	intersection	NOUN
gs-3960	141	3	between	between	ADP
gs-3960	141	4	protein	protein	NOUN
gs-3960	141	5	aggregation	aggregation	NOUN
gs-3960	141	6	and	and	CCONJ
gs-3960	141	7	mitochondrial	mitochondrial	ADJ
gs-3960	141	8	failure	failure	NOUN
gs-3960	141	9	may	may	AUX
gs-3960	141	10	represent	represent	VERB
gs-3960	141	11	a	a	DET
gs-3960	141	12	key	key	ADJ
gs-3960	141	13	considerable	considerable	ADJ
gs-3960	141	14	interest	interest	NOUN
gs-3960	141	15	but	but	CCONJ
gs-3960	141	16	remains	remain	VERB
gs-3960	141	17	controversial	controversial	ADJ
gs-3960	141	18	.	.	PUNCT
gs-3960	142	1	while	while	SCONJ
gs-3960	142	2	some	some	DET
gs-3960	142	3	studies	study	NOUN
gs-3960	142	4	report	report	VERB
gs-3960	142	5	increased	increase	VERB
gs-3960	142	6	the	the	DET
gs-3960	142	7	clonal	clonal	ADJ
gs-3960	142	8	nature	nature	NOUN
gs-3960	142	9	of	of	ADP
gs-3960	142	10	these	these	DET
gs-3960	142	11	mutations	mutation	NOUN
gs-3960	142	12	makes	make	VERB
gs-3960	142	13	their	their	PRON
gs-3960	142	14	pathogenic	pathogenic	ADJ
gs-3960	142	15	significance	significance	NOUN
gs-3960	142	16	unclear	unclear	ADJ
gs-3960	142	17	.	.	PUNCT
gs-3960	143	1	what	what	PRON
gs-3960	143	2	is	be	AUX
gs-3960	143	3	certain	certain	ADJ
gs-3960	143	4	is	be	AUX
gs-3960	143	5	that	that	SCONJ
gs-3960	143	6	mtdna	mtdna	PROPN
gs-3960	143	7	is	be	AUX
gs-3960	143	8	particularly	particularly	ADV
gs-3960	143	9	vulnerable	vulnerable	ADJ
gs-3960	143	10	to	to	ADP
gs-3960	143	11	oxidative	oxidative	ADJ
gs-3960	143	12	damage	damage	NOUN
gs-3960	143	13	due	due	ADP
gs-3960	143	14	to	to	ADP
gs-3960	143	15	its	its	PRON
gs-3960	143	16	proximity	proximity	NOUN
gs-3960	143	17	to	to	ADP
gs-3960	143	18	the	the	DET
gs-3960	143	19	electron	electron	NOUN
gs-3960	143	20	transport	transport	NOUN
gs-3960	143	21	chain	chain	NOUN
gs-3960	143	22	and	and	CCONJ
gs-3960	143	23	lack	lack	NOUN
gs-3960	143	24	of	of	ADP
gs-3960	143	25	protective	protective	ADJ
gs-3960	143	26	histones	histone	NOUN
gs-3960	143	27	.	.	PUNCT
gs-3960	144	1	the	the	DET
gs-3960	144	2	discovery	discovery	NOUN
gs-3960	144	3	that	that	PRON
gs-3960	144	4	polg	polg	VERB
gs-3960	144	5	mutations	mutation	NOUN
gs-3960	144	6	(	(	PUNCT
gs-3960	144	7	encoding	encode	VERB
gs-3960	144	8	mitochondrial	mitochondrial	ADJ
gs-3960	144	9	dna	dna	NOUN
gs-3960	144	10	polymerase	polymerase	NOUN
gs-3960	144	11	)	)	PUNCT
gs-3960	144	12	can	can	AUX
gs-3960	144	13	cause	cause	VERB
gs-3960	144	14	parkinsonism	parkinsonism	NOUN
gs-3960	144	15	in	in	ADP
gs-3960	144	16	some	some	DET
gs-3960	144	17	families	family	NOUN
gs-3960	144	18	supports	support	VERB
gs-3960	144	19	the	the	DET
gs-3960	144	20	notion	notion	NOUN
gs-3960	144	21	that	that	SCONJ
gs-3960	144	22	mtdna	mtdna	PROPN
gs-3960	144	23	integrity	integrity	NOUN
gs-3960	144	24	is	be	AUX
gs-3960	144	25	crucial	crucial	ADJ
gs-3960	144	26	for	for	ADP
gs-3960	144	27	dopaminergic	dopaminergic	ADJ
gs-3960	144	28	neuron	neuron	NOUN
gs-3960	144	29	survival	survival	NOUN
gs-3960	145	1	[	[	X
gs-3960	145	2	16,19,77	16,19,77	NUM
gs-3960	145	3	]	]	PUNCT
gs-3960	145	4	.	.	PUNCT
gs-3960	146	1	neuroinflammation	neuroinflammation	NOUN
gs-3960	146	2	adds	add	VERB
gs-3960	146	3	another	another	DET
gs-3960	146	4	layer	layer	NOUN
gs-3960	146	5	of	of	ADP
gs-3960	146	6	complexity	complexity	NOUN
gs-3960	146	7	to	to	ADP
gs-3960	146	8	mitochondrial	mitochondrial	ADJ
gs-3960	146	9	dysfunction	dysfunction	NOUN
gs-3960	146	10	further	further	ADJ
gs-3960	146	11	damage	damage	NOUN
gs-3960	146	12	neuronal	neuronal	ADJ
gs-3960	146	13	mitochondria	mitochondria	NOUN
gs-3960	146	14	,	,	PUNCT
gs-3960	146	15	creating	create	VERB
gs-3960	146	16	a	a	DET
gs-3960	146	17	vicious	vicious	ADJ
gs-3960	146	18	cycle	cycle	NOUN
gs-3960	146	19	of	of	ADP
gs-3960	146	20	oxidative	oxidative	ADJ
gs-3960	146	21	stress	stress	NOUN
gs-3960	146	22	and	and	CCONJ
gs-3960	146	23	inflammation	inflammation	NOUN
gs-3960	146	24	.	.	PUNCT
gs-3960	147	1	interestingly	interestingly	ADV
gs-3960	147	2	,	,	PUNCT
gs-3960	147	3	damaged	damaged	ADJ
gs-3960	147	4	mitochondria	mitochondria	NOUN
gs-3960	147	5	themselves	themselves	PRON
gs-3960	147	6	can	can	AUX
gs-3960	147	7	release	release	VERB
gs-3960	147	8	dangerassociated	dangerassociate	VERB
gs-3960	147	9	molecular	molecular	ADJ
gs-3960	147	10	patterns	pattern	NOUN
gs-3960	147	11	(	(	PUNCT
gs-3960	147	12	damps	damps	VERB
gs-3960	147	13	)	)	PUNCT
gs-3960	147	14	like	like	ADP
gs-3960	147	15	mtdna	mtdna	ADV
gs-3960	147	16	and	and	CCONJ
gs-3960	147	17	cardiolipin	cardiolipin	NOUN
gs-3960	147	18	that	that	PRON
gs-3960	147	19	activate	activate	VERB
gs-3960	147	20	innate	innate	ADJ
gs-3960	147	21	immune	immune	ADJ
gs-3960	147	22	responses	response	NOUN
gs-3960	147	23	.	.	PUNCT
gs-3960	148	1	this	this	DET
gs-3960	148	2	mitochondria	mitochondria	NOUN
gs-3960	148	3	-	-	PUNCT
gs-3960	148	4	immune	immune	ADJ
gs-3960	148	5	crosstalk	crosstalk	NOUN
gs-3960	148	6	may	may	AUX
gs-3960	148	7	explain	explain	VERB
gs-3960	148	8	why	why	SCONJ
gs-3960	148	9	epidemiological	epidemiological	ADJ
gs-3960	148	10	wide	wide	ADJ
gs-3960	148	11	association	association	NOUN
gs-3960	148	12	studies	study	NOUN
gs-3960	148	13	[	[	X
gs-3960	148	14	17,21,78	17,21,78	X
gs-3960	148	15	]	]	X
gs-3960	148	16	.	.	PUNCT
gs-3960	149	1	the	the	DET
gs-3960	149	2	therapeutic	therapeutic	ADJ
gs-3960	149	3	implications	implication	NOUN
gs-3960	149	4	of	of	ADP
gs-3960	149	5	mitochondrial	mitochondrial	ADJ
gs-3960	149	6	dysfunction	dysfunction	NOUN
gs-3960	149	7	are	be	AUX
gs-3960	149	8	profound	profound	ADJ
gs-3960	149	9	but	but	CCONJ
gs-3960	149	10	challenging	challenging	ADJ
gs-3960	149	11	.	.	PUNCT
gs-3960	150	1	while	while	SCONJ
gs-3960	150	2	strategies	strategy	NOUN
gs-3960	150	3	like	like	ADP
gs-3960	150	4	nad+	nad+	PROPN
gs-3960	150	5	supplementation	supplementation	NOUN
gs-3960	150	6	,	,	PUNCT
gs-3960	150	7	mitophagy	mitophagy	NOUN
gs-3960	150	8	enhancers	enhancer	NOUN
gs-3960	150	9	,	,	PUNCT
gs-3960	150	10	and	and	CCONJ
gs-3960	150	11	mitochondrial	mitochondrial	ADJ
gs-3960	150	12	antioxidants	antioxidant	NOUN
gs-3960	150	13	show	show	VERB
gs-3960	150	14	promise	promise	NOUN
gs-3960	150	15	in	in	ADP
gs-3960	150	16	preclinical	preclinical	ADJ
gs-3960	150	17	models	model	NOUN
gs-3960	150	18	,	,	PUNCT
gs-3960	150	19	translating	translate	VERB
gs-3960	150	20	these	these	DET
gs-3960	150	21	approaches	approach	NOUN
gs-3960	150	22	to	to	ADP
gs-3960	150	23	human	human	ADJ
gs-3960	150	24	patients	patient	NOUN
gs-3960	150	25	has	have	AUX
gs-3960	150	26	proven	prove	VERB
gs-3960	150	27	difficult	difficult	ADJ
gs-3960	150	28	.	.	PUNCT
gs-3960	151	1	the	the	DET
gs-3960	151	2	blood	blood	NOUN
gs-3960	151	3	-	-	PUNCT
gs-3960	151	4	brain	brain	NOUN
gs-3960	151	5	barrier	barrier	NOUN
gs-3960	151	6	presents	present	VERB
gs-3960	151	7	a	a	DET
gs-3960	151	8	major	major	ADJ
gs-3960	151	9	obstacle	obstacle	NOUN
gs-3960	151	10	for	for	ADP
gs-3960	151	11	drug	drug	NOUN
gs-3960	151	12	delivery	delivery	NOUN
gs-3960	151	13	,	,	PUNCT
gs-3960	151	14	and	and	CCONJ
gs-3960	151	15	the	the	DET
gs-3960	151	16	systemic	systemic	ADJ
gs-3960	151	17	effects	effect	NOUN
gs-3960	151	18	of	of	ADP
gs-3960	151	19	modulating	modulate	VERB
gs-3960	151	20	fundamental	fundamental	ADJ
gs-3960	151	21	processes	process	NOUN
gs-3960	151	22	like	like	ADP
gs-3960	151	23	mitophagy	mitophagy	NOUN
gs-3960	151	24	raise	raise	VERB
gs-3960	151	25	safety	safety	NOUN
gs-3960	151	26	concerns	concern	NOUN
gs-3960	151	27	.	.	PUNCT
gs-3960	152	1	nevertheless	nevertheless	ADV
gs-3960	152	2	,	,	PUNCT
gs-3960	152	3	several	several	ADJ
gs-3960	152	4	clinical	clinical	ADJ
gs-3960	152	5	trials	trial	NOUN
gs-3960	152	6	are	be	AUX
gs-3960	152	7	underway	underway	ADJ
gs-3960	152	8	,	,	PUNCT
gs-3960	152	9	testing	testing	NOUN
gs-3960	152	10	compounds	compound	NOUN
gs-3960	152	11	like	like	ADP
gs-3960	152	12	coenzyme	coenzyme	PROPN
gs-3960	152	13	q10	q10	PROPN
gs-3960	152	14	,	,	PUNCT
gs-3960	152	15	mitoquinone	mitoquinone	NOUN
gs-3960	152	16	,	,	PUNCT
gs-3960	152	17	and	and	CCONJ
gs-3960	152	18	ursodeoxycholic	ursodeoxycholic	PROPN
gs-3960	152	19	acid	acid	NOUN
gs-3960	152	20	for	for	ADP
gs-3960	152	21	their	their	PRON
gs-3960	152	22	emerging	emerge	VERB
gs-3960	152	23	technologies	technology	NOUN
gs-3960	152	24	offer	offer	VERB
gs-3960	152	25	new	new	ADJ
gs-3960	152	26	hope	hope	NOUN
gs-3960	152	27	for	for	ADP
gs-3960	152	28	mitochondrial	mitochondrial	ADJ
gs-3960	152	29	-	-	PUNCT
gs-3960	152	30	targeted	target	VERB
gs-3960	152	31	therapies	therapy	NOUN
gs-3960	152	32	.	.	PUNCT
gs-3960	153	1	gene	gene	NOUN
gs-3960	153	2	therapy	therapy	NOUN
gs-3960	153	3	approaches	approach	VERB
gs-3960	153	4	using	use	VERB
gs-3960	153	5	aav	aav	NOUN
gs-3960	153	6	vectors	vector	NOUN
gs-3960	153	7	to	to	PART
gs-3960	153	8	deliver	deliver	VERB
gs-3960	153	9	pink1	pink1	NOUN
gs-3960	153	10	or	or	CCONJ
gs-3960	153	11	parkin	parkin	ADJ
gs-3960	153	12	,	,	PUNCT
gs-3960	153	13	mitochondrial	mitochondrial	ADJ
gs-3960	153	14	transplantation	transplantation	NOUN
gs-3960	153	15	techniques	technique	NOUN
gs-3960	153	16	,	,	PUNCT
gs-3960	153	17	and	and	CCONJ
gs-3960	153	18	novel	novel	ADJ
gs-3960	153	19	compounds	compound	NOUN
gs-3960	153	20	that	that	PRON
gs-3960	153	21	can	can	AUX
gs-3960	153	22	selectively	selectively	ADV
gs-3960	153	23	target	target	VERB
gs-3960	153	24	antioxidants	antioxidant	NOUN
gs-3960	153	25	to	to	ADP
gs-3960	153	26	mitochondria	mitochondria	NOUN
gs-3960	153	27	are	be	AUX
gs-3960	153	28	all	all	ADV
gs-3960	153	29	under	under	ADP
gs-3960	153	30	active	active	ADJ
gs-3960	153	31	investigation	investigation	NOUN
gs-3960	153	32	.	.	PUNCT
gs-3960	154	1	perhaps	perhaps	ADV
gs-3960	154	2	most	most	ADV
gs-3960	154	3	intriguing	intriguing	ADJ
gs-3960	154	4	is	be	AUX
gs-3960	154	5	the	the	DET
gs-3960	154	6	growing	grow	VERB
gs-3960	154	7	recognition	recognition	NOUN
gs-3960	154	8	that	that	SCONJ
gs-3960	154	9	lifestyle	lifestyle	NOUN
gs-3960	154	10	interventions	intervention	NOUN
gs-3960	154	11	like	like	ADP
gs-3960	154	12	aerobic	aerobic	ADJ
gs-3960	154	13	exercise	exercise	NOUN
gs-3960	154	14	and	and	CCONJ
gs-3960	154	15	dietary	dietary	ADJ
gs-3960	154	16	restriction	restriction	NOUN
gs-3960	154	17	may	may	AUX
gs-3960	154	18	exert	exert	VERB
gs-3960	154	19	their	their	PRON
gs-3960	154	20	neuroprotective	neuroprotective	ADJ
gs-3960	154	21	effects	effect	NOUN
gs-3960	154	22	in	in	ADP
gs-3960	154	23	part	part	NOUN
gs-3960	154	24	through	through	ADP
gs-3960	154	25	improving	improve	VERB
gs-3960	154	26	mitochondrial	mitochondrial	ADJ
gs-3960	154	27	quality	quality	NOUN
gs-3960	154	28	control	control	NOUN
gs-3960	154	29	mechanisms	mechanism	NOUN
gs-3960	154	30	[	[	X
gs-3960	154	31	19	19	NUM
gs-3960	154	32	,	,	PUNCT
gs-3960	154	33	76,79	76,79	NOUN
gs-3960	154	34	]	]	X
gs-3960	154	35	.	.	PUNCT
gs-3960	155	1	as	as	SCONJ
gs-3960	155	2	research	research	NOUN
gs-3960	155	3	continues	continue	VERB
gs-3960	155	4	,	,	PUNCT
gs-3960	155	5	it	it	PRON
gs-3960	155	6	becomes	become	VERB
gs-3960	155	7	increasingly	increasingly	ADV
gs-3960	155	8	clear	clear	ADJ
gs-3960	155	9	that	that	SCONJ
gs-3960	155	10	mitochondrial	mitochondrial	ADJ
gs-3960	155	11	dysfunction	dysfunction	NOUN
gs-3960	155	12	a	a	DET
gs-3960	155	13	central	central	ADJ
gs-3960	155	14	driver	driver	NOUN
gs-3960	155	15	of	of	ADP
gs-3960	155	16	the	the	DET
gs-3960	155	17	pathogenic	pathogenic	ADJ
gs-3960	155	18	cascade	cascade	NOUN
gs-3960	155	19	.	.	PUNCT
gs-3960	156	1	the	the	DET
gs-3960	156	2	unique	unique	ADJ
gs-3960	156	3	vulnerabilities	vulnerability	NOUN
gs-3960	156	4	of	of	ADP
gs-3960	156	5	dopaminergic	dopaminergic	ADJ
gs-3960	156	6	georgian	georgian	NOUN
gs-3960	156	7	scientists/	scientists/	NUM
gs-3960	156	8	.	.	PUNCT
gs-3960	157	1	7	7	NUM
gs-3960	157	2	n	n	PRON
gs-3960	157	3	3	3	NUM
gs-3960	157	4	,	,	PUNCT
gs-3960	157	5	2025	2025	NUM
gs-3960	157	6	407	407	NUM
gs-3960	157	7	of	of	ADP
gs-3960	157	8	mitochondrial	mitochondrial	ADJ
gs-3960	157	9	failure	failure	NOUN
gs-3960	157	10	.	.	PUNCT
gs-3960	158	1	understanding	understand	VERB
gs-3960	158	2	these	these	DET
gs-3960	158	3	interactions	interaction	NOUN
gs-3960	158	4	at	at	ADP
gs-3960	158	5	a	a	DET
gs-3960	158	6	deeper	deep	ADJ
gs-3960	158	7	level	level	NOUN
gs-3960	158	8	may	may	AUX
gs-3960	158	9	hold	hold	VERB
gs-3960	158	10	the	the	DET
gs-3960	158	11	key	key	NOUN
gs-3960	158	12	to	to	ADP
gs-3960	158	13	developing	develop	VERB
gs-3960	158	14	therapies	therapy	NOUN
gs-3960	158	15	that	that	PRON
gs-3960	158	16	can	can	AUX
gs-3960	158	17	truly	truly	ADV
gs-3960	158	18	modify	modify	VERB
gs-3960	158	19	the	the	DET
gs-3960	158	20	course	course	NOUN
gs-3960	158	21	of	of	ADP
gs-3960	158	22	this	this	DET
gs-3960	158	23	devastating	devastating	ADJ
gs-3960	158	24	disease	disease	NOUN
gs-3960	158	25	.	.	PUNCT
gs-3960	159	1	disease	disease	NOUN
gs-3960	159	2	,	,	PUNCT
gs-3960	159	3	as	as	SCONJ
gs-3960	159	4	similar	similar	ADJ
gs-3960	159	5	mechanisms	mechanism	NOUN
gs-3960	159	6	have	have	AUX
gs-3960	159	7	been	be	AUX
gs-3960	159	8	implicated	implicate	VERB
gs-3960	159	9	in	in	ADP
gs-3960	159	10	other	other	ADJ
gs-3960	159	11	neurodegenerative	neurodegenerative	ADJ
gs-3960	159	12	disorders	disorder	NOUN
gs-3960	159	13	,	,	PUNCT
gs-3960	159	14	applications	application	NOUN
gs-3960	159	15	,	,	PUNCT
gs-3960	159	16	potentially	potentially	ADV
gs-3960	159	17	informing	inform	VERB
gs-3960	159	18	the	the	DET
gs-3960	159	19	development	development	NOUN
gs-3960	159	20	of	of	ADP
gs-3960	159	21	therapies	therapy	NOUN
gs-3960	159	22	for	for	ADP
gs-3960	159	23	a	a	DET
gs-3960	159	24	wide	wide	ADJ
gs-3960	159	25	range	range	NOUN
gs-3960	159	26	of	of	ADP
gs-3960	159	27	mitochondrial	mitochondrial	ADJ
gs-3960	159	28	function	function	NOUN
gs-3960	159	29	as	as	ADP
gs-3960	159	30	a	a	DET
gs-3960	159	31	means	means	NOUN
gs-3960	159	32	of	of	ADP
gs-3960	159	33	promoting	promote	VERB
gs-3960	159	34	overall	overall	ADJ
gs-3960	159	35	brain	brain	NOUN
gs-3960	159	36	health	health	NOUN
gs-3960	159	37	[	[	X
gs-3960	159	38	20,27,82	20,27,82	NUM
gs-3960	159	39	]	]	PUNCT
gs-3960	159	40	.	.	PUNCT
gs-3960	160	1	disruptions	disruption	NOUN
gs-3960	160	2	in	in	ADP
gs-3960	160	3	mitophagy	mitophagy	NOUN
gs-3960	160	4	and	and	CCONJ
gs-3960	160	5	nad+	nad+	PROPN
gs-3960	160	6	metabolism	metabolism	NOUN
gs-3960	160	7	playing	play	VERB
gs-3960	160	8	particularly	particularly	ADV
gs-3960	160	9	prominent	prominent	ADJ
gs-3960	160	10	roles	role	NOUN
gs-3960	160	11	.	.	PUNCT
gs-3960	161	1	the	the	DET
gs-3960	161	2	interplay	interplay	NOUN
gs-3960	161	3	between	between	ADP
gs-3960	161	4	these	these	DET
gs-3960	161	5	pathways	pathway	NOUN
gs-3960	161	6	offers	offer	VERB
gs-3960	161	7	a	a	DET
gs-3960	161	8	rich	rich	ADJ
gs-3960	161	9	landscape	landscape	NOUN
gs-3960	161	10	for	for	ADP
gs-3960	161	11	therapeutic	therapeutic	ADJ
gs-3960	161	12	exploration	exploration	NOUN
gs-3960	161	13	,	,	PUNCT
gs-3960	161	14	though	though	SCONJ
gs-3960	161	15	significant	significant	ADJ
gs-3960	161	16	hurdles	hurdle	NOUN
gs-3960	161	17	remain	remain	VERB
gs-3960	161	18	in	in	ADP
gs-3960	161	19	bringing	bring	VERB
gs-3960	161	20	these	these	DET
gs-3960	161	21	strategies	strategy	NOUN
gs-3960	161	22	to	to	ADP
gs-3960	161	23	the	the	DET
gs-3960	161	24	clinic	clinic	NOUN
gs-3960	161	25	.	.	PUNCT
gs-3960	162	1	as	as	SCONJ
gs-3960	162	2	research	research	NOUN
gs-3960	162	3	continues	continue	VERB
gs-3960	162	4	to	to	PART
gs-3960	162	5	unravel	unravel	VERB
gs-3960	162	6	the	the	DET
gs-3960	162	7	complexities	complexity	NOUN
gs-3960	162	8	of	of	ADP
gs-3960	162	9	mitochondrial	mitochondrial	ADJ
gs-3960	162	10	biology	biology	NOUN
gs-3960	162	11	in	in	ADP
gs-3960	162	12	the	the	DET
gs-3960	162	13	context	context	NOUN
gs-3960	162	14	of	of	ADP
gs-3960	162	15	neurodegeneration	neurodegeneration	NOUN
gs-3960	162	16	,	,	PUNCT
gs-3960	162	17	the	the	DET
gs-3960	162	18	hope	hope	NOUN
gs-3960	162	19	is	be	AUX
gs-3960	162	20	that	that	SCONJ
gs-3960	162	21	these	these	DET
gs-3960	162	22	insights	insight	NOUN
gs-3960	162	23	will	will	AUX
gs-3960	162	24	pave	pave	VERB
gs-3960	162	25	the	the	DET
gs-3960	162	26	way	way	NOUN
gs-3960	162	27	for	for	ADP
gs-3960	162	28	innovative	innovative	ADJ
gs-3960	162	29	those	those	PRON
gs-3960	162	30	affected	affect	VERB
gs-3960	162	31	by	by	ADP
gs-3960	162	32	it	it	PRON
gs-3960	162	33	.	.	PUNCT
gs-3960	163	1	goal	goal	NOUN
gs-3960	163	2	of	of	ADP
gs-3960	163	3	the	the	DET
gs-3960	163	4	study	study	NOUN
gs-3960	163	5	:	:	PUNCT
gs-3960	163	6	advancing	advance	VERB
gs-3960	163	7	therapeutic	therapeutic	ADJ
gs-3960	163	8	strategies	strategy	NOUN
gs-3960	163	9	for	for	ADP
gs-3960	163	10	parkinson	parkinson	NOUN
gs-3960	163	11	s	s	PART
gs-3960	163	12	disease	disease	NOUN
gs-3960	163	13	through	through	ADP
gs-3960	163	14	mitochondrial	mitochondrial	ADJ
gs-3960	163	15	modulation	modulation	NOUN
gs-3960	163	16	the	the	DET
gs-3960	163	17	overarching	overarching	ADJ
gs-3960	163	18	goal	goal	NOUN
gs-3960	163	19	of	of	ADP
gs-3960	163	20	this	this	DET
gs-3960	163	21	study	study	NOUN
gs-3960	163	22	is	be	AUX
gs-3960	163	23	to	to	PART
gs-3960	163	24	critically	critically	ADV
gs-3960	163	25	evaluate	evaluate	VERB
gs-3960	163	26	and	and	CCONJ
gs-3960	163	27	synthesize	synthesize	VERB
gs-3960	163	28	current	current	ADJ
gs-3960	163	29	scientific	scientific	ADJ
gs-3960	163	30	(	(	PUNCT
gs-3960	163	31	pd	pd	NOUN
gs-3960	163	32	)	)	PUNCT
gs-3960	163	33	,	,	PUNCT
gs-3960	163	34	with	with	ADP
gs-3960	163	35	a	a	DET
gs-3960	163	36	focused	focused	ADJ
gs-3960	163	37	exploration	exploration	NOUN
gs-3960	163	38	of	of	ADP
gs-3960	163	39	mitophagy	mitophagy	NOUN
gs-3960	163	40	and	and	CCONJ
gs-3960	163	41	nad+	nad+	PROPN
gs-3960	163	42	metabolism	metabolism	NOUN
gs-3960	163	43	as	as	ADP
gs-3960	163	44	pivotal	pivotal	ADJ
gs-3960	163	45	therapeutic	therapeutic	ADJ
gs-3960	163	46	targets	target	NOUN
gs-3960	163	47	.	.	PUNCT
gs-3960	164	1	by	by	ADP
gs-3960	164	2	integrating	integrate	VERB
gs-3960	164	3	molecular	molecular	ADJ
gs-3960	164	4	,	,	PUNCT
gs-3960	164	5	cellular	cellular	ADJ
gs-3960	164	6	,	,	PUNCT
gs-3960	164	7	and	and	CCONJ
gs-3960	164	8	clinical	clinical	ADJ
gs-3960	164	9	research	research	NOUN
gs-3960	164	10	,	,	PUNCT
gs-3960	164	11	this	this	DET
gs-3960	164	12	work	work	NOUN
gs-3960	164	13	aims	aim	VERB
gs-3960	164	14	to	to	PART
gs-3960	164	15	:	:	PUNCT
gs-3960	164	16	elucidate	elucidate	VERB
gs-3960	164	17	pathogenic	pathogenic	ADJ
gs-3960	164	18	mechanisms	mechanism	NOUN
gs-3960	164	19	investigate	investigate	VERB
gs-3960	164	20	how	how	SCONJ
gs-3960	164	21	disruptions	disruption	NOUN
gs-3960	164	22	in	in	ADP
gs-3960	164	23	mitochondrial	mitochondrial	ADJ
gs-3960	164	24	quality	quality	NOUN
gs-3960	164	25	control	control	NOUN
gs-3960	164	26	(	(	PUNCT
gs-3960	164	27	particularly	particularly	ADV
gs-3960	164	28	mitophagy	mitophagy	ADJ
gs-3960	164	29	)	)	PUNCT
gs-3960	164	30	contribute	contribute	VERB
gs-3960	164	31	to	to	ADP
gs-3960	164	32	dopaminergic	dopaminergic	ADJ
gs-3960	164	33	neuron	neuron	NOUN
gs-3960	164	34	degeneration	degeneration	NOUN
gs-3960	164	35	.	.	PUNCT
gs-3960	165	1	examine	examine	VERB
gs-3960	165	2	the	the	DET
gs-3960	165	3	role	role	NOUN
gs-3960	165	4	of	of	ADP
gs-3960	165	5	nad+	nad+	PROPN
gs-3960	165	6	depletion	depletion	NOUN
gs-3960	165	7	in	in	ADP
gs-3960	165	8	exacerbating	exacerbate	VERB
gs-3960	165	9	mitochondrial	mitochondrial	ADJ
gs-3960	165	10	dysfunction	dysfunction	NOUN
gs-3960	165	11	and	and	CCONJ
gs-3960	165	12	cellular	cellular	ADJ
gs-3960	165	13	vulnerability	vulnerability	NOUN
gs-3960	165	14	in	in	ADP
gs-3960	165	15	pd	pd	PROPN
gs-3960	165	16	.	.	PROPN
gs-3960	165	17	explore	explore	VERB
gs-3960	165	18	the	the	DET
gs-3960	165	19	interplay	interplay	NOUN
gs-3960	165	20	between	between	ADP
gs-3960	165	21	genetic	genetic	ADJ
gs-3960	165	22	mutations	mutation	NOUN
gs-3960	165	23	(	(	PUNCT
gs-3960	165	24	e.g.	e.g.	ADV
gs-3960	165	25	,	,	PUNCT
gs-3960	165	26	,	,	PUNCT
gs-3960	165	27	)	)	PUNCT
gs-3960	165	28	and	and	CCONJ
gs-3960	165	29	environmental	environmental	ADJ
gs-3960	165	30	factors	factor	NOUN
gs-3960	165	31	(	(	PUNCT
gs-3960	165	32	e.g.	e.g.	ADV
gs-3960	165	33	,	,	PUNCT
gs-3960	165	34	toxins	toxin	NOUN
gs-3960	165	35	,	,	PUNCT
gs-3960	165	36	aging	aging	NOUN
gs-3960	165	37	)	)	PUNCT
gs-3960	165	38	in	in	ADP
gs-3960	165	39	driving	drive	VERB
gs-3960	165	40	mitochondrial	mitochondrial	ADJ
gs-3960	165	41	failure	failure	NOUN
gs-3960	165	42	.	.	PUNCT
gs-3960	166	1	evaluate	evaluate	VERB
gs-3960	166	2	emerging	emerge	VERB
gs-3960	166	3	therapeutic	therapeutic	ADJ
gs-3960	166	4	strategies	strategy	NOUN
gs-3960	166	5	assess	assess	VERB
gs-3960	166	6	preclinical	preclinical	ADJ
gs-3960	166	7	and	and	CCONJ
gs-3960	166	8	clinical	clinical	ADJ
gs-3960	166	9	evidence	evidence	NOUN
gs-3960	166	10	for	for	ADP
gs-3960	166	11	therapies	therapy	NOUN
gs-3960	166	12	targeting	target	VERB
gs-3960	166	13	mitophagy	mitophagy	NOUN
gs-3960	166	14	enhancement	enhancement	NOUN
gs-3960	166	15	(	(	PUNCT
gs-3960	166	16	e.g.	e.g.	ADV
gs-3960	166	17	,	,	PUNCT
gs-3960	166	18	pink1	pink1	NOUN
gs-3960	166	19	/	/	SYM
gs-3960	166	20	parkin	parkin	ADJ
gs-3960	166	21	activators	activator	NOUN
gs-3960	166	22	,	,	PUNCT
gs-3960	166	23	urolithin	urolithin	PROPN
gs-3960	166	24	a	a	PRON
gs-3960	166	25	)	)	PUNCT
gs-3960	166	26	.	.	PUNCT
gs-3960	167	1	analyze	analyze	VERB
gs-3960	167	2	the	the	DET
gs-3960	167	3	potential	potential	NOUN
gs-3960	167	4	of	of	ADP
gs-3960	167	5	nad+	nad+	PROPN
gs-3960	167	6	restoration	restoration	NOUN
gs-3960	167	7	(	(	PUNCT
gs-3960	167	8	via	via	ADP
gs-3960	167	9	precursors	precursor	NOUN
gs-3960	167	10	like	like	ADP
gs-3960	167	11	nmn	nmn	PROPN
gs-3960	167	12	/	/	SYM
gs-3960	167	13	nr	nr	PROPN
gs-3960	167	14	or	or	CCONJ
gs-3960	167	15	cd38	cd38	PROPN
gs-3960	167	16	inhibitors	inhibitor	NOUN
gs-3960	167	17	)	)	PUNCT
gs-3960	167	18	to	to	PART
gs-3960	167	19	improve	improve	VERB
gs-3960	167	20	mitochondrial	mitochondrial	ADJ
gs-3960	167	21	bioenergetics	bioenergetic	NOUN
gs-3960	167	22	and	and	CCONJ
gs-3960	167	23	neuronal	neuronal	ADJ
gs-3960	167	24	resilience	resilience	NOUN
gs-3960	167	25	.	.	PUNCT
gs-3960	168	1	discuss	discuss	VERB
gs-3960	168	2	combinatorial	combinatorial	ADJ
gs-3960	168	3	approaches	approach	NOUN
gs-3960	168	4	that	that	PRON
gs-3960	168	5	simultaneously	simultaneously	ADV
gs-3960	168	6	address	address	NOUN
gs-3960	168	7	mitophagy	mitophagy	NOUN
gs-3960	168	8	,	,	PUNCT
gs-3960	168	9	nad+	nad+	PROPN
gs-3960	168	10	metabolism	metabolism	NOUN
gs-3960	168	11	,	,	PUNCT
gs-3960	168	12	and	and	CCONJ
gs-3960	168	13	oxidative	oxidative	ADJ
gs-3960	168	14	stress	stress	NOUN
gs-3960	168	15	.	.	PUNCT
gs-3960	169	1	address	address	VERB
gs-3960	169	2	translational	translational	ADJ
gs-3960	169	3	challenges	challenge	NOUN
gs-3960	169	4	georgian	georgian	NOUN
gs-3960	169	5	scientists/	scientists/	NUM
gs-3960	169	6	.	.	PUNCT
gs-3960	170	1	7	7	NUM
gs-3960	170	2	n	n	PRON
gs-3960	170	3	3	3	NUM
gs-3960	170	4	,	,	PUNCT
gs-3960	170	5	2025	2025	NUM
gs-3960	170	6	408	408	NUM
gs-3960	170	7	identify	identify	VERB
gs-3960	170	8	barriers	barrier	NOUN
gs-3960	170	9	to	to	ADP
gs-3960	170	10	clinical	clinical	ADJ
gs-3960	170	11	implementation	implementation	NOUN
gs-3960	170	12	,	,	PUNCT
gs-3960	170	13	including	include	VERB
gs-3960	170	14	drug	drug	NOUN
gs-3960	170	15	delivery	delivery	NOUN
gs-3960	170	16	across	across	ADP
gs-3960	170	17	the	the	DET
gs-3960	170	18	bloodbrain	bloodbrain	NOUN
gs-3960	170	19	barrier	barrier	NOUN
gs-3960	170	20	,	,	PUNCT
gs-3960	170	21	biomarker	biomarker	NOUN
gs-3960	170	22	development	development	NOUN
gs-3960	170	23	,	,	PUNCT
gs-3960	170	24	and	and	CCONJ
gs-3960	170	25	patient	patient	ADJ
gs-3960	170	26	stratification	stratification	NOUN
gs-3960	170	27	.	.	PUNCT
gs-3960	171	1	propose	propose	VERB
gs-3960	171	2	frameworks	framework	NOUN
gs-3960	171	3	for	for	ADP
gs-3960	171	4	optimizing	optimize	VERB
gs-3960	171	5	clinical	clinical	ADJ
gs-3960	171	6	trial	trial	NOUN
gs-3960	171	7	design	design	NOUN
gs-3960	171	8	to	to	PART
gs-3960	171	9	evaluate	evaluate	VERB
gs-3960	171	10	mitochondrialtargeted	mitochondrialtargete	VERB
gs-3960	171	11	therapies	therapy	NOUN
gs-3960	171	12	in	in	ADP
gs-3960	171	13	pd	pd	PROPN
gs-3960	171	14	.	.	PROPN
gs-3960	171	15	highlight	highlight	VERB
gs-3960	171	16	future	future	ADJ
gs-3960	171	17	directions	direction	NOUN
gs-3960	171	18	advocate	advocate	VERB
gs-3960	171	19	for	for	ADP
gs-3960	171	20	research	research	NOUN
gs-3960	171	21	into	into	ADP
gs-3960	171	22	novel	novel	ADJ
gs-3960	171	23	targets	target	NOUN
gs-3960	171	24	(	(	PUNCT
gs-3960	171	25	e.g.	e.g.	ADV
gs-3960	171	26	,	,	PUNCT
gs-3960	171	27	mitochondrial	mitochondrial	ADJ
gs-3960	171	28	dynamics	dynamic	NOUN
gs-3960	171	29	,	,	PUNCT
gs-3960	171	30	mtdna	mtdna	NOUN
gs-3960	171	31	repair	repair	NOUN
gs-3960	171	32	)	)	PUNCT
gs-3960	171	33	and	and	CCONJ
gs-3960	171	34	technologies	technology	NOUN
gs-3960	171	35	(	(	PUNCT
gs-3960	171	36	e.g.	e.g.	ADV
gs-3960	171	37	,	,	PUNCT
gs-3960	171	38	gene	gene	NOUN
gs-3960	171	39	therapy	therapy	NOUN
gs-3960	171	40	,	,	PUNCT
gs-3960	171	41	mitochondrial	mitochondrial	ADJ
gs-3960	171	42	transplantation	transplantation	NOUN
gs-3960	171	43	)	)	PUNCT
gs-3960	171	44	.	.	PUNCT
gs-3960	172	1	emphasize	emphasize	VERB
gs-3960	172	2	the	the	DET
gs-3960	172	3	importance	importance	NOUN
gs-3960	172	4	of	of	ADP
gs-3960	172	5	personalized	personalized	ADJ
gs-3960	172	6	medicine	medicine	NOUN
gs-3960	172	7	,	,	PUNCT
gs-3960	172	8	leveraging	leverage	VERB
gs-3960	172	9	genetic	genetic	ADJ
gs-3960	172	10	and	and	CCONJ
gs-3960	172	11	metabolic	metabolic	NOUN
gs-3960	172	12	profiling	profiling	NOUN
gs-3960	172	13	to	to	PART
gs-3960	172	14	tailor	tailor	VERB
gs-3960	172	15	mitochondrial	mitochondrial	ADJ
gs-3960	172	16	therapies	therapy	NOUN
gs-3960	172	17	.	.	PUNCT
gs-3960	173	1	by	by	ADP
gs-3960	173	2	bridging	bridge	VERB
gs-3960	173	3	mechanistic	mechanistic	ADJ
gs-3960	173	4	insights	insight	NOUN
gs-3960	173	5	with	with	ADP
gs-3960	173	6	therapeutic	therapeutic	ADJ
gs-3960	173	7	innovation	innovation	NOUN
gs-3960	173	8	,	,	PUNCT
gs-3960	173	9	this	this	DET
gs-3960	173	10	study	study	NOUN
gs-3960	173	11	seeks	seek	VERB
gs-3960	173	12	to	to	PART
gs-3960	173	13	advance	advance	VERB
gs-3960	173	14	the	the	DET
gs-3960	173	15	development	development	NOUN
gs-3960	173	16	of	of	ADP
gs-3960	173	17	disease	disease	NOUN
gs-3960	173	18	-	-	PUNCT
gs-3960	173	19	modifying	modify	VERB
gs-3960	173	20	strategies	strategy	NOUN
gs-3960	173	21	that	that	PRON
gs-3960	173	22	preserve	preserve	VERB
gs-3960	173	23	neuronal	neuronal	ADJ
gs-3960	173	24	function	function	NOUN
gs-3960	173	25	and	and	CCONJ
gs-3960	173	26	slow	slow	ADJ
gs-3960	173	27	pd	pd	NOUN
gs-3960	173	28	progression	progression	NOUN
gs-3960	173	29	,	,	PUNCT
gs-3960	173	30	ultimately	ultimately	ADV
gs-3960	173	31	improving	improve	VERB
gs-3960	173	32	quality	quality	NOUN
gs-3960	173	33	of	of	ADP
gs-3960	173	34	life	life	NOUN
gs-3960	173	35	for	for	ADP
gs-3960	173	36	patients	patient	NOUN
gs-3960	173	37	.	.	PUNCT
gs-3960	174	1	results	result	NOUN
gs-3960	174	2	and	and	CCONJ
gs-3960	174	3	discussion	discussion	NOUN
gs-3960	174	4	profound	profound	ADJ
gs-3960	174	5	insights	insight	NOUN
gs-3960	174	6	,	,	PUNCT
gs-3960	174	7	revealing	reveal	VERB
gs-3960	174	8	intricate	intricate	ADJ
gs-3960	174	9	mechanisms	mechanism	NOUN
gs-3960	174	10	that	that	PRON
gs-3960	174	11	underscore	underscore	VERB
gs-3960	174	12	the	the	DET
gs-3960	174	13	vulnerability	vulnerability	NOUN
gs-3960	174	14	of	of	ADP
gs-3960	174	15	dopaminergic	dopaminergic	ADJ
gs-3960	174	16	neurons	neuron	NOUN
gs-3960	174	17	and	and	CCONJ
gs-3960	174	18	presenting	present	VERB
gs-3960	174	19	novel	novel	ADJ
gs-3960	174	20	opportunities	opportunity	NOUN
gs-3960	174	21	for	for	ADP
gs-3960	174	22	therapeutic	therapeutic	ADJ
gs-3960	174	23	intervention	intervention	NOUN
gs-3960	174	24	.	.	PUNCT
gs-3960	175	1	central	central	ADJ
gs-3960	175	2	to	to	ADP
gs-3960	175	3	these	these	DET
gs-3960	175	4	findings	finding	NOUN
gs-3960	175	5	is	be	AUX
gs-3960	175	6	the	the	DET
gs-3960	175	7	recognition	recognition	NOUN
gs-3960	175	8	that	that	SCONJ
gs-3960	175	9	mitochondrial	mitochondrial	ADJ
gs-3960	175	10	impairment	impairment	NOUN
gs-3960	175	11	is	be	AUX
gs-3960	175	12	not	not	PART
gs-3960	175	13	merely	merely	ADV
gs-3960	175	14	a	a	DET
gs-3960	175	15	secondary	secondary	ADJ
gs-3960	175	16	consequence	consequence	NOUN
gs-3960	175	17	of	of	ADP
gs-3960	175	18	neurodegeneration	neurodegeneration	NOUN
gs-3960	175	19	but	but	CCONJ
gs-3960	175	20	a	a	DET
gs-3960	175	21	primary	primary	ADJ
gs-3960	175	22	driver	driver	NOUN
gs-3960	175	23	of	of	ADP
gs-3960	175	24	the	the	DET
gs-3960	175	25	pathological	pathological	ADJ
gs-3960	175	26	mitophagy	mitophagy	NOUN
gs-3960	175	27	and	and	CCONJ
gs-3960	175	28	nad+	nad+	PROPN
gs-3960	175	29	metabolism	metabolism	NOUN
gs-3960	175	30	in	in	ADP
gs-3960	175	31	neuronal	neuronal	ADJ
gs-3960	175	32	survival	survival	NOUN
gs-3960	175	33	.	.	PUNCT
gs-3960	176	1	these	these	DET
gs-3960	176	2	discoveries	discovery	NOUN
gs-3960	176	3	not	not	PART
gs-3960	176	4	only	only	ADV
gs-3960	176	5	deepen	deepen	VERB
gs-3960	176	6	harnessed	harness	VERB
gs-3960	176	7	to	to	PART
gs-3960	176	8	develop	develop	VERB
gs-3960	176	9	targeted	targeted	ADJ
gs-3960	176	10	treatments	treatment	NOUN
gs-3960	176	11	.	.	PUNCT
gs-3960	177	1	mitophagy	mitophagy	PROPN
gs-3960	177	2	,	,	PUNCT
gs-3960	177	3	the	the	DET
gs-3960	177	4	selective	selective	ADJ
gs-3960	177	5	degradation	degradation	NOUN
gs-3960	177	6	of	of	ADP
gs-3960	177	7	damaged	damage	VERB
gs-3960	177	8	mitochondria	mitochondria	NOUN
gs-3960	177	9	,	,	PUNCT
gs-3960	177	10	has	have	AUX
gs-3960	177	11	emerged	emerge	VERB
gs-3960	177	12	as	as	ADP
gs-3960	177	13	a	a	DET
gs-3960	177	14	employing	employ	VERB
gs-3960	177	15	patient	patient	NOUN
gs-3960	177	16	-	-	PUNCT
gs-3960	177	17	derived	derive	VERB
gs-3960	177	18	induced	induce	VERB
gs-3960	177	19	pluripotent	pluripotent	ADJ
gs-3960	177	20	stem	stem	NOUN
gs-3960	177	21	cells	cell	NOUN
gs-3960	177	22	(	(	PUNCT
gs-3960	177	23	ipscs	ipscs	NOUN
gs-3960	177	24	)	)	PUNCT
gs-3960	177	25	differentiated	differentiate	VERB
gs-3960	177	26	into	into	ADP
gs-3960	177	27	dopaminergic	dopaminergic	ADJ
gs-3960	177	28	neurons	neuron	NOUN
gs-3960	177	29	have	have	AUX
gs-3960	177	30	demonstrated	demonstrate	VERB
gs-3960	177	31	that	that	SCONJ
gs-3960	177	32	mutations	mutation	NOUN
gs-3960	177	33	in	in	ADP
gs-3960	177	34	or	or	CCONJ
gs-3960	177	35	lead	lead	VERB
gs-3960	177	36	to	to	ADP
gs-3960	177	37	the	the	DET
gs-3960	177	38	accumulation	accumulation	NOUN
gs-3960	177	39	of	of	ADP
gs-3960	177	40	dysfunctional	dysfunctional	ADJ
gs-3960	177	41	mitochondria	mitochondria	NOUN
gs-3960	177	42	,	,	PUNCT
gs-3960	177	43	heightened	heighten	VERB
gs-3960	177	44	oxidative	oxidative	ADJ
gs-3960	177	45	stress	stress	NOUN
gs-3960	177	46	,	,	PUNCT
gs-3960	177	47	and	and	CCONJ
gs-3960	177	48	eventual	eventual	ADJ
gs-3960	177	49	neuronal	neuronal	ADJ
gs-3960	177	50	death	death	NOUN
gs-3960	177	51	.	.	PUNCT
gs-3960	178	1	these	these	DET
gs-3960	178	2	findings	finding	NOUN
gs-3960	178	3	are	be	AUX
gs-3960	178	4	corroborated	corroborate	VERB
gs-3960	178	5	by	by	ADP
gs-3960	178	6	animal	animal	NOUN
gs-3960	178	7	models	model	NOUN
gs-3960	178	8	,	,	PUNCT
gs-3960	178	9	where	where	SCONJ
gs-3960	178	10	or	or	CCONJ
gs-3960	178	11	knockout	knockout	NOUN
gs-3960	178	12	results	result	NOUN
gs-3960	178	13	in	in	ADP
gs-3960	178	14	mitochondrial	mitochondrial	ADJ
gs-3960	178	15	abnormalities	abnormality	NOUN
gs-3960	178	16	and	and	CCONJ
gs-3960	178	17	motor	motor	NOUN
gs-3960	178	18	deficits	deficit	NOUN
gs-3960	178	19	function	function	VERB
gs-3960	178	20	and	and	CCONJ
gs-3960	178	21	improves	improve	VERB
gs-3960	178	22	neuronal	neuronal	ADJ
gs-3960	178	23	survival	survival	NOUN
gs-3960	178	24	.	.	PUNCT
gs-3960	179	1	for	for	ADP
gs-3960	179	2	instance	instance	NOUN
gs-3960	179	3	,	,	PUNCT
gs-3960	179	4	compounds	compound	VERB
gs-3960	179	5	such	such	ADJ
gs-3960	179	6	as	as	ADP
gs-3960	179	7	urolithin	urolithin	PROPN
gs-3960	179	8	a	a	NOUN
gs-3960	179	9	,	,	PUNCT
gs-3960	179	10	known	know	VERB
gs-3960	179	11	to	to	PART
gs-3960	179	12	enhance	enhance	VERB
gs-3960	179	13	mitophagy	mitophagy	NOUN
gs-3960	179	14	,	,	PUNCT
gs-3960	179	15	have	have	AUX
gs-3960	179	16	shown	show	VERB
gs-3960	179	17	promise	promise	NOUN
gs-3960	179	18	in	in	ADP
gs-3960	179	19	preclinical	preclinical	ADJ
gs-3960	179	20	studies	study	NOUN
gs-3960	179	21	by	by	ADP
gs-3960	179	22	reducing	reduce	VERB
gs-3960	179	23	mitochondrial	mitochondrial	ADJ
gs-3960	179	24	damage	damage	NOUN
gs-3960	179	25	and	and	CCONJ
gs-3960	179	26	mitigating	mitigate	VERB
gs-3960	179	27	neurodegeneration	neurodegeneration	NOUN
gs-3960	179	28	in	in	ADP
gs-3960	179	29	and	and	CCONJ
gs-3960	179	30	rodent	rodent	ADJ
gs-3960	179	31	models	model	NOUN
gs-3960	179	32	mitophagy	mitophagy	NOUN
gs-3960	179	33	could	could	AUX
gs-3960	179	34	represent	represent	VERB
gs-3960	179	35	a	a	DET
gs-3960	179	36	viable	viable	ADJ
gs-3960	179	37	strategy	strategy	NOUN
gs-3960	179	38	for	for	ADP
gs-3960	179	39	slowing	slow	VERB
gs-3960	179	40	disease	disease	NOUN
gs-3960	179	41	progression	progression	NOUN
gs-3960	179	42	.	.	PUNCT
gs-3960	180	1	parallel	parallel	ADJ
gs-3960	180	2	to	to	ADP
gs-3960	180	3	these	these	DET
gs-3960	180	4	discoveries	discovery	NOUN
gs-3960	180	5	,	,	PUNCT
gs-3960	180	6	research	research	NOUN
gs-3960	180	7	into	into	ADP
gs-3960	180	8	nad+	nad+	PROPN
gs-3960	180	9	metabolism	metabolism	NOUN
gs-3960	180	10	has	have	AUX
gs-3960	180	11	unveiled	unveil	VERB
gs-3960	180	12	its	its	PRON
gs-3960	180	13	essential	essential	ADJ
gs-3960	180	14	role	role	NOUN
gs-3960	180	15	in	in	ADP
gs-3960	180	16	maintaining	maintain	VERB
gs-3960	180	17	mitochondrial	mitochondrial	ADJ
gs-3960	180	18	health	health	NOUN
gs-3960	180	19	and	and	CCONJ
gs-3960	180	20	cellular	cellular	ADJ
gs-3960	180	21	resilience	resilience	NOUN
gs-3960	180	22	.	.	PUNCT
gs-3960	181	1	nad+	nad+	NOUN
gs-3960	181	2	levels	level	NOUN
gs-3960	181	3	georgian	georgian	VERB
gs-3960	181	4	scientists/	scientists/	NUM
gs-3960	181	5	.	.	PUNCT
gs-3960	182	1	7	7	NUM
gs-3960	182	2	n	n	PRON
gs-3960	182	3	3	3	NUM
gs-3960	182	4	,	,	PUNCT
gs-3960	182	5	2025	2025	NUM
gs-3960	182	6	409	409	NUM
gs-3960	182	7	bioenergetic	bioenergetic	ADJ
gs-3960	182	8	failure	failure	NOUN
gs-3960	182	9	and	and	CCONJ
gs-3960	182	10	impaired	impaired	ADJ
gs-3960	182	11	stress	stress	NOUN
gs-3960	182	12	responses	response	NOUN
gs-3960	182	13	.	.	PUNCT
gs-3960	183	1	experimental	experimental	ADJ
gs-3960	183	2	evidence	evidence	NOUN
gs-3960	183	3	from	from	ADP
gs-3960	183	4	both	both	PRON
gs-3960	183	5	and	and	CCONJ
gs-3960	183	6	restores	restore	VERB
gs-3960	183	7	mitochondrial	mitochondrial	ADJ
gs-3960	183	8	function	function	NOUN
gs-3960	183	9	,	,	PUNCT
gs-3960	183	10	reduces	reduce	VERB
gs-3960	183	11	oxidative	oxidative	ADJ
gs-3960	183	12	stress	stress	NOUN
gs-3960	183	13	,	,	PUNCT
gs-3960	183	14	and	and	CCONJ
gs-3960	183	15	protects	protect	VERB
gs-3960	183	16	dopaminergic	dopaminergic	ADJ
gs-3960	183	17	improve	improve	VERB
gs-3960	183	18	motor	motor	NOUN
gs-3960	183	19	function	function	NOUN
gs-3960	183	20	and	and	CCONJ
gs-3960	183	21	reduce	reduce	VERB
gs-3960	183	22	the	the	DET
gs-3960	183	23	loss	loss	NOUN
gs-3960	183	24	of	of	ADP
gs-3960	183	25	nigral	nigral	ADJ
gs-3960	183	26	neurons	neuron	NOUN
gs-3960	183	27	.	.	PUNCT
gs-3960	184	1	these	these	DET
gs-3960	184	2	effects	effect	NOUN
gs-3960	184	3	are	be	AUX
gs-3960	184	4	mediated	mediate	VERB
gs-3960	184	5	,	,	PUNCT
gs-3960	184	6	in	in	ADP
gs-3960	184	7	part	part	NOUN
gs-3960	184	8	,	,	PUNCT
gs-3960	184	9	through	through	ADP
gs-3960	184	10	the	the	DET
gs-3960	184	11	activation	activation	NOUN
gs-3960	184	12	of	of	ADP
gs-3960	184	13	nad+-dependent	nad+-dependent	ADJ
gs-3960	184	14	enzymes	enzyme	NOUN
gs-3960	184	15	such	such	ADJ
gs-3960	184	16	as	as	ADP
gs-3960	184	17	sirtuins	sirtuin	NOUN
gs-3960	184	18	,	,	PUNCT
gs-3960	184	19	which	which	PRON
gs-3960	184	20	regulate	regulate	VERB
gs-3960	184	21	mitochondrial	mitochondrial	ADJ
gs-3960	184	22	biogenesis	biogenesis	NOUN
gs-3960	184	23	,	,	PUNCT
gs-3960	184	24	antioxidant	antioxidant	NOUN
gs-3960	184	25	defenses	defense	NOUN
gs-3960	184	26	,	,	PUNCT
gs-3960	184	27	and	and	CCONJ
gs-3960	184	28	dna	dna	PROPN
gs-3960	184	29	repair	repair	NOUN
gs-3960	184	30	.	.	PUNCT
gs-3960	185	1	the	the	DET
gs-3960	185	2	consistency	consistency	NOUN
gs-3960	185	3	of	of	ADP
gs-3960	185	4	these	these	DET
gs-3960	185	5	findings	finding	NOUN
gs-3960	185	6	across	across	ADP
gs-3960	185	7	different	different	ADJ
gs-3960	185	8	model	model	NOUN
gs-3960	185	9	systems	system	NOUN
gs-3960	185	10	underscores	underscore	VERB
gs-3960	185	11	the	the	DET
gs-3960	185	12	potential	potential	NOUN
gs-3960	185	13	of	of	ADP
gs-3960	185	14	nad+	nad+	PROPN
gs-3960	185	15	modulation	modulation	NOUN
gs-3960	185	16	as	as	ADP
gs-3960	185	17	a	a	DET
gs-3960	185	18	therapeutic	therapeutic	ADJ
gs-3960	185	19	avenue	avenue	NOUN
gs-3960	185	20	.	.	PUNCT
gs-3960	186	1	the	the	DET
gs-3960	186	2	interplay	interplay	NOUN
gs-3960	186	3	between	between	ADP
gs-3960	186	4	mitophagy	mitophagy	NOUN
gs-3960	186	5	and	and	CCONJ
gs-3960	186	6	nad+	nad+	PROPN
gs-3960	186	7	metabolism	metabolism	NOUN
gs-3960	186	8	represents	represent	VERB
gs-3960	186	9	a	a	DET
gs-3960	186	10	particularly	particularly	ADV
gs-3960	186	11	compelling	compelling	ADJ
gs-3960	186	12	area	area	NOUN
gs-3960	186	13	of	of	ADP
gs-3960	186	14	investigation	investigation	NOUN
gs-3960	186	15	.	.	PUNCT
gs-3960	187	1	while	while	SCONJ
gs-3960	187	2	mitophagy	mitophagy	NOUN
gs-3960	187	3	ensures	ensure	VERB
gs-3960	187	4	the	the	DET
gs-3960	187	5	removal	removal	NOUN
gs-3960	187	6	of	of	ADP
gs-3960	187	7	damaged	damage	VERB
gs-3960	187	8	mitochondria	mitochondria	NOUN
gs-3960	187	9	,	,	PUNCT
gs-3960	187	10	nad+	nad+	PROPN
gs-3960	187	11	supports	support	VERB
gs-3960	187	12	the	the	DET
gs-3960	187	13	bioenergetic	bioenergetic	ADJ
gs-3960	187	14	and	and	CCONJ
gs-3960	187	15	reparative	reparative	ADJ
gs-3960	187	16	capacity	capacity	NOUN
gs-3960	187	17	of	of	ADP
gs-3960	187	18	the	the	DET
gs-3960	187	19	remaining	remain	VERB
gs-3960	187	20	organelles	organelle	NOUN
gs-3960	187	21	.	.	PUNCT
gs-3960	188	1	disruptions	disruption	NOUN
gs-3960	188	2	in	in	ADP
gs-3960	188	3	either	either	DET
gs-3960	188	4	pathway	pathway	NOUN
gs-3960	188	5	can	can	AUX
gs-3960	188	6	tip	tip	VERB
gs-3960	188	7	the	the	DET
gs-3960	188	8	balance	balance	NOUN
gs-3960	188	9	toward	toward	ADP
gs-3960	188	10	neurodegeneration	neurodegeneration	NOUN
gs-3960	188	11	,	,	PUNCT
gs-3960	188	12	but	but	CCONJ
gs-3960	188	13	emerging	emerge	VERB
gs-3960	188	14	evidence	evidence	NOUN
gs-3960	188	15	suggests	suggest	VERB
gs-3960	188	16	that	that	SCONJ
gs-3960	188	17	their	their	PRON
gs-3960	188	18	synergistic	synergistic	ADJ
gs-3960	188	19	enhancement	enhancement	NOUN
gs-3960	188	20	may	may	AUX
gs-3960	188	21	offer	offer	VERB
gs-3960	188	22	greater	great	ADJ
gs-3960	188	23	neuroprotection	neuroprotection	NOUN
gs-3960	188	24	than	than	ADP
gs-3960	188	25	targeting	target	VERB
gs-3960	188	26	either	either	CCONJ
gs-3960	188	27	pathway	pathway	NOUN
gs-3960	188	28	alone	alone	ADV
gs-3960	188	29	.	.	PUNCT
gs-3960	189	1	for	for	ADP
gs-3960	189	2	example	example	NOUN
gs-3960	189	3	,	,	PUNCT
gs-3960	189	4	combined	combined	ADJ
gs-3960	189	5	treatment	treatment	NOUN
gs-3960	189	6	with	with	ADP
gs-3960	189	7	mitophagy	mitophagy	NOUN
gs-3960	189	8	inducers	inducer	NOUN
gs-3960	189	9	and	and	CCONJ
gs-3960	189	10	nad+	nad+	NOUN
gs-3960	189	11	precursors	precursor	NOUN
gs-3960	189	12	has	have	AUX
gs-3960	189	13	been	be	AUX
gs-3960	189	14	shown	show	VERB
gs-3960	189	15	to	to	PART
gs-3960	189	16	produce	produce	VERB
gs-3960	189	17	additive	additive	ADJ
gs-3960	189	18	benefits	benefit	NOUN
gs-3960	189	19	in	in	ADP
gs-3960	189	20	preclinical	preclinical	ADJ
gs-3960	189	21	models	model	NOUN
gs-3960	189	22	,	,	PUNCT
gs-3960	189	23	improving	improve	VERB
gs-3960	189	24	mitochondrial	mitochondrial	ADJ
gs-3960	189	25	function	function	NOUN
gs-3960	189	26	and	and	CCONJ
gs-3960	189	27	neuronal	neuronal	ADJ
gs-3960	189	28	survival	survival	NOUN
gs-3960	189	29	more	more	ADV
gs-3960	189	30	effectively	effectively	ADV
gs-3960	189	31	than	than	ADP
gs-3960	189	32	single	single	ADJ
gs-3960	189	33	interventions	intervention	NOUN
gs-3960	189	34	.	.	PUNCT
gs-3960	190	1	this	this	DET
gs-3960	190	2	synergy	synergy	NOUN
gs-3960	190	3	highlights	highlight	VERB
gs-3960	190	4	the	the	DET
gs-3960	190	5	importance	importance	NOUN
gs-3960	190	6	of	of	ADP
gs-3960	190	7	a	a	DET
gs-3960	190	8	multifaceted	multifaceted	ADJ
gs-3960	190	9	therapeutic	therapeutic	ADJ
gs-3960	190	10	approach	approach	NOUN
gs-3960	190	11	that	that	PRON
gs-3960	190	12	addresses	address	VERB
gs-3960	190	13	multiple	multiple	ADJ
gs-3960	190	14	aspects	aspect	NOUN
gs-3960	190	15	of	of	ADP
gs-3960	190	16	mitochondrial	mitochondrial	ADJ
gs-3960	190	17	dysfunction	dysfunction	NOUN
gs-3960	190	18	.	.	PUNCT
gs-3960	191	1	translating	translate	VERB
gs-3960	191	2	these	these	DET
gs-3960	191	3	preclinical	preclinical	ADJ
gs-3960	191	4	findings	finding	NOUN
gs-3960	191	5	into	into	ADP
gs-3960	191	6	clinical	clinical	ADJ
gs-3960	191	7	applications	application	NOUN
gs-3960	191	8	presents	present	VERB
gs-3960	191	9	both	both	DET
gs-3960	191	10	opportunities	opportunity	NOUN
gs-3960	191	11	and	and	CCONJ
gs-3960	191	12	challenges	challenge	NOUN
gs-3960	191	13	.	.	PUNCT
gs-3960	192	1	early	early	ADJ
gs-3960	192	2	-	-	PUNCT
gs-3960	192	3	phase	phase	NOUN
gs-3960	192	4	clinical	clinical	ADJ
gs-3960	192	5	trials	trial	NOUN
gs-3960	192	6	exploring	explore	VERB
gs-3960	192	7	nad+	nad+	PROPN
gs-3960	192	8	precursors	precursor	NOUN
gs-3960	192	9	in	in	ADP
gs-3960	192	10	improvements	improvement	NOUN
gs-3960	192	11	in	in	ADP
gs-3960	192	12	biomarkers	biomarker	NOUN
gs-3960	192	13	of	of	ADP
gs-3960	192	14	mitochondrial	mitochondrial	ADJ
gs-3960	192	15	function	function	NOUN
gs-3960	192	16	and	and	CCONJ
gs-3960	192	17	modest	modest	ADJ
gs-3960	192	18	clinical	clinical	ADJ
gs-3960	192	19	benefits	benefit	NOUN
gs-3960	192	20	.	.	PUNCT
gs-3960	193	1	however	however	ADV
gs-3960	193	2	,	,	PUNCT
gs-3960	193	3	challenges	challenge	NOUN
gs-3960	193	4	such	such	ADJ
gs-3960	193	5	as	as	ADP
gs-3960	193	6	bioavailability	bioavailability	NOUN
gs-3960	193	7	,	,	PUNCT
gs-3960	193	8	blood	blood	NOUN
gs-3960	193	9	-	-	PUNCT
gs-3960	193	10	brain	brain	NOUN
gs-3960	193	11	barrier	barrier	NOUN
gs-3960	193	12	penetration	penetration	NOUN
gs-3960	193	13	,	,	PUNCT
gs-3960	193	14	and	and	CCONJ
gs-3960	193	15	long	long	ADJ
gs-3960	193	16	-	-	PUNCT
gs-3960	193	17	term	term	NOUN
gs-3960	193	18	safety	safety	NOUN
gs-3960	193	19	remain	remain	VERB
gs-3960	193	20	to	to	PART
gs-3960	193	21	be	be	AUX
gs-3960	193	22	addressed	address	VERB
gs-3960	193	23	.	.	PUNCT
gs-3960	194	1	similarly	similarly	ADV
gs-3960	194	2	,	,	PUNCT
gs-3960	194	3	while	while	SCONJ
gs-3960	194	4	mitophagy	mitophagy	NOUN
gs-3960	194	5	-	-	PUNCT
gs-3960	194	6	enhancing	enhance	VERB
gs-3960	194	7	compounds	compound	NOUN
gs-3960	194	8	like	like	ADP
gs-3960	194	9	urolithin	urolithin	PROPN
gs-3960	194	10	a	a	PRON
gs-3960	194	11	are	be	AUX
gs-3960	194	12	under	under	ADP
gs-3960	194	13	investigation	investigation	NOUN
gs-3960	194	14	for	for	ADP
gs-3960	194	15	age	age	NOUN
gs-3960	194	16	-	-	PUNCT
gs-3960	194	17	related	relate	VERB
gs-3960	194	18	conditions	condition	NOUN
gs-3960	194	19	,	,	PUNCT
gs-3960	194	20	their	their	PRON
gs-3960	194	21	efficacy	efficacy	NOUN
gs-3960	194	22	and	and	CCONJ
gs-3960	194	23	safety	safety	NOUN
gs-3960	194	24	in	in	ADP
gs-3960	194	25	rigorous	rigorous	ADJ
gs-3960	194	26	clinical	clinical	ADJ
gs-3960	194	27	testing	testing	NOUN
gs-3960	194	28	and	and	CCONJ
gs-3960	194	29	the	the	DET
gs-3960	194	30	development	development	NOUN
gs-3960	194	31	of	of	ADP
gs-3960	194	32	biomarkers	biomarker	NOUN
gs-3960	194	33	to	to	PART
gs-3960	194	34	monitor	monitor	VERB
gs-3960	194	35	target	target	NOUN
gs-3960	194	36	engagement	engagement	NOUN
gs-3960	194	37	and	and	CCONJ
gs-3960	194	38	therapeutic	therapeutic	ADJ
gs-3960	194	39	response	response	NOUN
gs-3960	194	40	.	.	PUNCT
gs-3960	195	1	beyond	beyond	ADP
gs-3960	195	2	mitophagy	mitophagy	NOUN
gs-3960	195	3	and	and	CCONJ
gs-3960	195	4	nad+	nad+	PROPN
gs-3960	195	5	metabolism	metabolism	NOUN
gs-3960	195	6	,	,	PUNCT
gs-3960	195	7	other	other	ADJ
gs-3960	195	8	mitochondrial	mitochondrial	ADJ
gs-3960	195	9	pathways	pathway	NOUN
gs-3960	195	10	have	have	AUX
gs-3960	195	11	garnered	garner	VERB
gs-3960	195	12	attention	attention	NOUN
gs-3960	195	13	as	as	ADP
gs-3960	195	14	potential	potential	ADJ
gs-3960	195	15	therapeutic	therapeutic	ADJ
gs-3960	195	16	targets	target	NOUN
gs-3960	195	17	.	.	PUNCT
gs-3960	196	1	for	for	ADP
gs-3960	196	2	instance	instance	NOUN
gs-3960	196	3	,	,	PUNCT
gs-3960	196	4	modulation	modulation	NOUN
gs-3960	196	5	of	of	ADP
gs-3960	196	6	with	with	ADP
gs-3960	196	7	compounds	compound	NOUN
gs-3960	196	8	that	that	PRON
gs-3960	196	9	promote	promote	VERB
gs-3960	196	10	fusion	fusion	NOUN
gs-3960	196	11	(	(	PUNCT
gs-3960	196	12	e.g.	e.g.	ADV
gs-3960	196	13	,	,	PUNCT
gs-3960	196	14	m1	m1	PROPN
gs-3960	196	15	,	,	PUNCT
gs-3960	196	16	a	a	DET
gs-3960	196	17	mitofusin	mitofusin	NOUN
gs-3960	196	18	activator	activator	NOUN
gs-3960	196	19	)	)	PUNCT
gs-3960	196	20	demonstrating	demonstrate	VERB
gs-3960	196	21	neuroprotective	neuroprotective	ADJ
gs-3960	196	22	effects	effect	NOUN
gs-3960	196	23	.	.	PUNCT
gs-3960	197	1	similarly	similarly	ADV
gs-3960	197	2	,	,	PUNCT
gs-3960	197	3	strategies	strategy	NOUN
gs-3960	197	4	aimed	aim	VERB
gs-3960	197	5	at	at	ADP
gs-3960	197	6	reducing	reduce	VERB
gs-3960	197	7	mitochondrial	mitochondrial	ADJ
gs-3960	197	8	oxidative	oxidative	ADJ
gs-3960	197	9	stress	stress	NOUN
gs-3960	197	10	,	,	PUNCT
gs-3960	197	11	such	such	ADJ
gs-3960	197	12	as	as	ADP
gs-3960	197	13	the	the	DET
gs-3960	197	14	use	use	NOUN
gs-3960	197	15	of	of	ADP
gs-3960	197	16	mitochondria	mitochondria	NOUN
gs-3960	197	17	-	-	PUNCT
gs-3960	197	18	targeted	target	VERB
gs-3960	197	19	antioxidants	antioxidant	NOUN
gs-3960	197	20	like	like	ADP
gs-3960	197	21	mitoq	mitoq	ADV
gs-3960	197	22	,	,	PUNCT
gs-3960	197	23	have	have	AUX
gs-3960	197	24	yielded	yield	VERB
gs-3960	197	25	mixed	mixed	ADJ
gs-3960	197	26	but	but	CCONJ
gs-3960	197	27	intriguing	intriguing	ADJ
gs-3960	197	28	results	result	NOUN
gs-3960	197	29	in	in	ADP
gs-3960	197	30	clinical	clinical	ADJ
gs-3960	197	31	trials	trial	NOUN
gs-3960	197	32	.	.	PUNCT
gs-3960	198	1	these	these	DET
gs-3960	198	2	diverse	diverse	ADJ
gs-3960	198	3	approaches	approach	NOUN
gs-3960	198	4	reflect	reflect	VERB
gs-3960	198	5	the	the	DET
gs-3960	198	6	georgian	georgian	NOUN
gs-3960	198	7	scientists/	scientists/	NUM
gs-3960	198	8	.	.	PUNCT
gs-3960	199	1	7	7	NUM
gs-3960	199	2	n	n	PRON
gs-3960	199	3	3	3	NUM
gs-3960	199	4	,	,	PUNCT
gs-3960	199	5	2025	2025	NUM
gs-3960	199	6	410	410	NUM
gs-3960	199	7	complexity	complexity	NOUN
gs-3960	199	8	of	of	ADP
gs-3960	199	9	mitochondrial	mitochondrial	ADJ
gs-3960	199	10	biology	biology	NOUN
gs-3960	199	11	and	and	CCONJ
gs-3960	199	12	the	the	DET
gs-3960	199	13	need	need	NOUN
gs-3960	199	14	for	for	ADP
gs-3960	199	15	tailored	tailored	ADJ
gs-3960	199	16	therapies	therapy	NOUN
gs-3960	199	17	that	that	PRON
gs-3960	199	18	address	address	VERB
gs-3960	199	19	specific	specific	ADJ
gs-3960	199	20	aspects	aspect	NOUN
gs-3960	199	21	of	of	ADP
gs-3960	199	22	dysfunction	dysfunction	NOUN
gs-3960	199	23	in	in	ADP
gs-3960	199	24	different	different	ADJ
gs-3960	199	25	patient	patient	NOUN
gs-3960	199	26	subgroups	subgroup	NOUN
gs-3960	199	27	.	.	PUNCT
gs-3960	200	1	insights	insight	NOUN
gs-3960	200	2	into	into	ADP
gs-3960	200	3	other	other	ADJ
gs-3960	200	4	neurodegenerative	neurodegenerative	ADJ
gs-3960	200	5	disorders	disorder	NOUN
gs-3960	200	6	where	where	SCONJ
gs-3960	200	7	mitochondrial	mitochondrial	ADJ
gs-3960	200	8	dysfunction	dysfunction	NOUN
gs-3960	200	9	is	be	AUX
gs-3960	200	10	a	a	DET
gs-3960	200	11	interventions	intervention	NOUN
gs-3960	200	12	to	to	PART
gs-3960	200	13	promote	promote	VERB
gs-3960	200	14	healthy	healthy	ADJ
gs-3960	200	15	brain	brain	NOUN
gs-3960	200	16	aging	aging	NOUN
gs-3960	200	17	and	and	CCONJ
gs-3960	200	18	prevent	prevent	NOUN
gs-3960	200	19	disease	disease	NOUN
gs-3960	200	20	onset	onset	VERB
gs-3960	200	21	.	.	PUNCT
gs-3960	201	1	the	the	DET
gs-3960	201	2	results	result	NOUN
gs-3960	201	3	of	of	ADP
gs-3960	201	4	this	this	DET
gs-3960	201	5	investigation	investigation	NOUN
gs-3960	201	6	underscore	underscore	VERB
gs-3960	201	7	the	the	DET
gs-3960	201	8	centrality	centrality	NOUN
gs-3960	201	9	of	of	ADP
gs-3960	201	10	mitochondrial	mitochondrial	ADJ
gs-3960	201	11	critical	critical	ADJ
gs-3960	201	12	therapeutic	therapeutic	ADJ
gs-3960	201	13	targets	target	NOUN
gs-3960	201	14	.	.	PUNCT
gs-3960	202	1	while	while	SCONJ
gs-3960	202	2	significant	significant	ADJ
gs-3960	202	3	progress	progress	NOUN
gs-3960	202	4	has	have	AUX
gs-3960	202	5	been	be	AUX
gs-3960	202	6	made	make	VERB
gs-3960	202	7	in	in	ADP
gs-3960	202	8	understanding	understand	VERB
gs-3960	202	9	these	these	DET
gs-3960	202	10	pathways	pathway	NOUN
gs-3960	202	11	,	,	PUNCT
gs-3960	202	12	much	much	ADJ
gs-3960	202	13	work	work	NOUN
gs-3960	202	14	remains	remain	VERB
gs-3960	202	15	to	to	PART
gs-3960	202	16	translate	translate	VERB
gs-3960	202	17	these	these	DET
gs-3960	202	18	discoveries	discovery	NOUN
gs-3960	202	19	into	into	ADP
gs-3960	202	20	effective	effective	ADJ
gs-3960	202	21	treatments	treatment	NOUN
gs-3960	202	22	.	.	PUNCT
gs-3960	203	1	future	future	ADJ
gs-3960	203	2	research	research	NOUN
gs-3960	203	3	should	should	AUX
gs-3960	203	4	focus	focus	VERB
gs-3960	203	5	on	on	ADP
gs-3960	203	6	optimizing	optimize	VERB
gs-3960	203	7	therapeutic	therapeutic	ADJ
gs-3960	203	8	compounds	compound	NOUN
gs-3960	203	9	,	,	PUNCT
gs-3960	203	10	identifying	identify	VERB
gs-3960	203	11	biomarkers	biomarker	NOUN
gs-3960	203	12	for	for	ADP
gs-3960	203	13	patient	patient	ADJ
gs-3960	203	14	stratification	stratification	NOUN
gs-3960	203	15	,	,	PUNCT
gs-3960	203	16	and	and	CCONJ
gs-3960	203	17	exploring	explore	VERB
gs-3960	203	18	combinatorial	combinatorial	ADJ
gs-3960	203	19	approaches	approach	NOUN
gs-3960	203	20	that	that	PRON
gs-3960	203	21	target	target	VERB
gs-3960	203	22	multiple	multiple	ADJ
gs-3960	203	23	aspects	aspect	NOUN
gs-3960	203	24	of	of	ADP
gs-3960	203	25	mitochondrial	mitochondrial	ADJ
gs-3960	203	26	biology	biology	NOUN
gs-3960	203	27	.	.	PUNCT
gs-3960	204	1	by	by	ADP
gs-3960	204	2	addressing	address	VERB
gs-3960	204	3	these	these	DET
gs-3960	204	4	challenges	challenge	NOUN
gs-3960	204	5	,	,	PUNCT
gs-3960	204	6	the	the	DET
gs-3960	204	7	field	field	NOUN
gs-3960	204	8	can	can	AUX
gs-3960	204	9	move	move	VERB
gs-3960	204	10	closer	close	ADV
gs-3960	204	11	to	to	ADP
gs-3960	204	12	developing	develop	VERB
gs-3960	204	13	disease	disease	NOUN
gs-3960	204	14	-	-	PUNCT
gs-3960	204	15	modifying	modify	VERB
gs-3960	204	16	therapies	therapy	NOUN
gs-3960	204	17	that	that	PRON
gs-3960	204	18	improve	improve	VERB
gs-3960	204	19	the	the	DET
gs-3960	204	20	lives	life	NOUN
gs-3960	204	21	of	of	ADP
gs-3960	204	22	individuals	individual	NOUN
gs-3960	204	23	affected	affect	VERB
gs-3960	204	24	by	by	ADP
gs-3960	204	25	the	the	DET
gs-3960	204	26	integrity	integrity	NOUN
gs-3960	204	27	of	of	ADP
gs-3960	204	28	dopaminergic	dopaminergic	ADJ
gs-3960	204	29	neurons	neuron	NOUN
gs-3960	204	30	in	in	ADP
gs-3960	204	31	the	the	DET
gs-3960	204	32	substantia	substantia	NOUN
gs-3960	204	33	nigra	nigra	PROPN
gs-3960	204	34	pars	par	NOUN
gs-3960	204	35	compacta	compacta	NOUN
gs-3960	204	36	is	be	AUX
gs-3960	204	37	critically	critically	ADV
gs-3960	204	38	dependent	dependent	ADJ
gs-3960	204	39	on	on	ADP
gs-3960	204	40	efficient	efficient	ADJ
gs-3960	204	41	mitochondrial	mitochondrial	ADJ
gs-3960	204	42	quality	quality	NOUN
gs-3960	204	43	control	control	NOUN
gs-3960	204	44	mechanisms	mechanism	NOUN
gs-3960	204	45	.	.	PUNCT
gs-3960	205	1	our	our	PRON
gs-3960	205	2	investigations	investigation	NOUN
gs-3960	205	3	reveal	reveal	VERB
gs-3960	205	4	that	that	SCONJ
gs-3960	205	5	the	the	DET
gs-3960	205	6	pink1	pink1	NOUN
gs-3960	205	7	-	-	PUNCT
gs-3960	205	8	parkin	parkin	NOUN
gs-3960	205	9	mediated	mediate	VERB
gs-3960	205	10	mitophagy	mitophagy	NOUN
gs-3960	205	11	pathway	pathway	NOUN
gs-3960	205	12	exhibits	exhibit	VERB
gs-3960	205	13	significant	significant	ADJ
gs-3960	205	14	impairment	impairment	NOUN
gs-3960	205	15	in	in	ADP
gs-3960	205	16	parkinson	parkinson	NOUN
gs-3960	205	17	's	's	PART
gs-3960	205	18	disease	disease	NOUN
gs-3960	205	19	patients	patient	NOUN
gs-3960	205	20	,	,	PUNCT
gs-3960	205	21	particularly	particularly	ADV
gs-3960	205	22	in	in	ADP
gs-3960	205	23	those	those	PRON
gs-3960	205	24	with	with	ADP
gs-3960	205	25	earlyonset	earlyonset	NOUN
gs-3960	205	26	forms	form	NOUN
gs-3960	205	27	of	of	ADP
gs-3960	205	28	the	the	DET
gs-3960	205	29	condition	condition	NOUN
gs-3960	205	30	.	.	PUNCT
gs-3960	206	1	through	through	ADP
gs-3960	206	2	advanced	advanced	ADJ
gs-3960	206	3	proteomic	proteomic	ADJ
gs-3960	206	4	analysis	analysis	NOUN
gs-3960	206	5	of	of	ADP
gs-3960	206	6	post	post	ADJ
gs-3960	206	7	-	-	ADJ
gs-3960	206	8	mortem	mortem	ADJ
gs-3960	206	9	brain	brain	NOUN
gs-3960	206	10	tissue	tissue	NOUN
gs-3960	206	11	,	,	PUNCT
gs-3960	206	12	we	we	PRON
gs-3960	206	13	identified	identify	VERB
gs-3960	206	14	a	a	DET
gs-3960	206	15	62	62	NUM
gs-3960	206	16	%	%	NOUN
gs-3960	206	17	reduction	reduction	NOUN
gs-3960	206	18	in	in	ADP
gs-3960	206	19	parkin	parkin	ADJ
gs-3960	206	20	activity	activity	NOUN
gs-3960	206	21	and	and	CCONJ
gs-3960	206	22	a	a	DET
gs-3960	206	23	73	73	NUM
gs-3960	206	24	%	%	NOUN
gs-3960	206	25	decrease	decrease	NOUN
gs-3960	206	26	in	in	ADP
gs-3960	206	27	pink1	pink1	NOUN
gs-3960	206	28	membrane	membrane	NOUN
gs-3960	206	29	stabilization	stabilization	NOUN
gs-3960	206	30	in	in	ADP
gs-3960	206	31	parkinson	parkinson	NOUN
gs-3960	206	32	's	's	PART
gs-3960	206	33	patients	patient	NOUN
gs-3960	206	34	compared	compare	VERB
gs-3960	206	35	to	to	ADP
gs-3960	206	36	age	age	NOUN
gs-3960	206	37	-	-	PUNCT
gs-3960	206	38	matched	match	VERB
gs-3960	206	39	controls	control	NOUN
gs-3960	206	40	.	.	PUNCT
gs-3960	207	1	these	these	DET
gs-3960	207	2	findings	finding	NOUN
gs-3960	207	3	were	be	AUX
gs-3960	207	4	corroborated	corroborate	VERB
gs-3960	207	5	in	in	ADP
gs-3960	207	6	live	live	ADJ
gs-3960	207	7	-	-	PUNCT
gs-3960	207	8	cell	cell	NOUN
gs-3960	207	9	imaging	imaging	NOUN
gs-3960	207	10	studies	study	NOUN
gs-3960	207	11	using	use	VERB
gs-3960	207	12	patient	patient	NOUN
gs-3960	207	13	-	-	PUNCT
gs-3960	207	14	derived	derive	VERB
gs-3960	207	15	induced	induce	VERB
gs-3960	207	16	pluripotent	pluripotent	ADJ
gs-3960	207	17	stem	stem	NOUN
gs-3960	207	18	cells	cell	NOUN
gs-3960	207	19	(	(	PUNCT
gs-3960	207	20	ipscs	ipscs	NOUN
gs-3960	207	21	)	)	PUNCT
gs-3960	207	22	,	,	PUNCT
gs-3960	207	23	where	where	SCONJ
gs-3960	207	24	mitochondria	mitochondria	NOUN
gs-3960	207	25	with	with	ADP
gs-3960	207	26	depolarized	depolarized	ADJ
gs-3960	207	27	membranes	membrane	NOUN
gs-3960	207	28	persisted	persist	VERB
gs-3960	207	29	3.8	3.8	NUM
gs-3960	207	30	times	time	NOUN
gs-3960	207	31	longer	long	ADV
gs-3960	207	32	in	in	ADP
gs-3960	207	33	parkinson's	parkinson's	NOUN
gs-3960	207	34	-	-	PUNCT
gs-3960	207	35	derived	derive	VERB
gs-3960	207	36	dopaminergic	dopaminergic	ADJ
gs-3960	207	37	neurons	neuron	NOUN
gs-3960	207	38	before	before	ADP
gs-3960	207	39	undergoing	undergo	VERB
gs-3960	207	40	mitophagy	mitophagy	NOUN
gs-3960	207	41	.	.	PUNCT
gs-3960	208	1	the	the	DET
gs-3960	208	2	consequences	consequence	NOUN
gs-3960	208	3	of	of	ADP
gs-3960	208	4	impaired	impaired	ADJ
gs-3960	208	5	mitophagy	mitophagy	NOUN
gs-3960	208	6	are	be	AUX
gs-3960	208	7	profound	profound	ADJ
gs-3960	208	8	.	.	PUNCT
gs-3960	209	1	using	use	VERB
gs-3960	209	2	super	super	ADJ
gs-3960	209	3	-	-	ADJ
gs-3960	209	4	resolution	resolution	ADJ
gs-3960	209	5	microscopy	microscopy	NOUN
gs-3960	209	6	,	,	PUNCT
gs-3960	209	7	we	we	PRON
gs-3960	209	8	observed	observe	VERB
gs-3960	209	9	that	that	SCONJ
gs-3960	209	10	parkinson	parkinson	NOUN
gs-3960	209	11	's	's	PART
gs-3960	209	12	patient	patient	ADJ
gs-3960	209	13	neurons	neuron	NOUN
gs-3960	209	14	accumulate	accumulate	VERB
gs-3960	209	15	mitochondria	mitochondria	NOUN
gs-3960	209	16	with	with	ADP
gs-3960	209	17	swollen	swollen	ADJ
gs-3960	209	18	cristae	cristae	ADJ
gs-3960	209	19	and	and	CCONJ
gs-3960	209	20	partial	partial	ADJ
gs-3960	209	21	matrix	matrix	NOUN
gs-3960	209	22	condensation	condensation	NOUN
gs-3960	209	23	classic	classic	ADJ
gs-3960	209	24	ultrastructural	ultrastructural	ADJ
gs-3960	209	25	signs	sign	NOUN
gs-3960	209	26	of	of	ADP
gs-3960	209	27	dysfunction	dysfunction	NOUN
gs-3960	209	28	.	.	PUNCT
gs-3960	210	1	these	these	DET
gs-3960	210	2	defective	defective	ADJ
gs-3960	210	3	organelles	organelle	NOUN
gs-3960	210	4	showed	show	VERB
gs-3960	210	5	a	a	DET
gs-3960	210	6	4.2	4.2	NUM
gs-3960	210	7	-	-	ADJ
gs-3960	210	8	fold	fold	ADJ
gs-3960	210	9	increase	increase	NOUN
gs-3960	210	10	in	in	ADP
gs-3960	210	11	reactive	reactive	ADJ
gs-3960	210	12	oxygen	oxygen	NOUN
gs-3960	210	13	species	specie	NOUN
gs-3960	210	14	production	production	NOUN
gs-3960	210	15	and	and	CCONJ
gs-3960	210	16	were	be	AUX
gs-3960	210	17	notably	notably	ADV
gs-3960	210	18	deficient	deficient	ADJ
gs-3960	210	19	in	in	ADP
gs-3960	210	20	atp	atp	PROPN
gs-3960	210	21	generation	generation	NOUN
gs-3960	210	22	,	,	PUNCT
gs-3960	210	23	producing	produce	VERB
gs-3960	210	24	only	only	ADV
gs-3960	210	25	38	38	NUM
gs-3960	210	26	%	%	NOUN
gs-3960	210	27	of	of	ADP
gs-3960	210	28	the	the	DET
gs-3960	210	29	atp	atp	NOUN
gs-3960	210	30	generated	generate	VERB
gs-3960	210	31	by	by	ADP
gs-3960	210	32	healthy	healthy	ADJ
gs-3960	210	33	mitochondria	mitochondria	NOUN
gs-3960	210	34	in	in	ADP
gs-3960	210	35	control	control	NOUN
gs-3960	210	36	neurons	neuron	NOUN
gs-3960	210	37	.	.	PUNCT
gs-3960	211	1	interestingly	interestingly	ADV
gs-3960	211	2	,	,	PUNCT
gs-3960	211	3	the	the	DET
gs-3960	211	4	distribution	distribution	NOUN
gs-3960	211	5	of	of	ADP
gs-3960	211	6	these	these	DET
gs-3960	211	7	damaged	damage	VERB
gs-3960	211	8	mitochondria	mitochondria	NOUN
gs-3960	211	9	was	be	AUX
gs-3960	211	10	not	not	PART
gs-3960	211	11	uniform	uniform	ADJ
gs-3960	211	12	,	,	PUNCT
gs-3960	211	13	with	with	ADP
gs-3960	211	14	axonal	axonal	ADJ
gs-3960	211	15	terminals	terminal	NOUN
gs-3960	211	16	showing	show	VERB
gs-3960	211	17	particularly	particularly	ADV
gs-3960	211	18	high	high	ADJ
gs-3960	211	19	concentrations	concentration	NOUN
gs-3960	211	20	of	of	ADP
gs-3960	211	21	dysfunctional	dysfunctional	ADJ
gs-3960	211	22	organelles	organelle	NOUN
gs-3960	211	23	,	,	PUNCT
gs-3960	211	24	potentially	potentially	ADV
gs-3960	211	25	explaining	explain	VERB
gs-3960	211	26	the	the	DET
gs-3960	211	27	"	"	PUNCT
gs-3960	211	28	dying	die	VERB
gs-3960	211	29	back	back	ADP
gs-3960	211	30	"	"	PUNCT
gs-3960	211	31	pattern	pattern	NOUN
gs-3960	211	32	of	of	ADP
gs-3960	211	33	neurodegeneration	neurodegeneration	NOUN
gs-3960	211	34	characteristic	characteristic	NOUN
gs-3960	211	35	of	of	ADP
gs-3960	211	36	parkinson	parkinson	NOUN
gs-3960	211	37	's	's	PART
gs-3960	211	38	disease	disease	NOUN
gs-3960	211	39	[	[	X
gs-3960	211	40	4,17,22,30	4,17,22,30	NOUN
gs-3960	211	41	]	]	PUNCT
gs-3960	211	42	.	.	PUNCT
gs-3960	212	1	georgian	georgian	PROPN
gs-3960	212	2	scientists/	scientists/	NUM
gs-3960	212	3	.	.	PUNCT
gs-3960	213	1	7	7	NUM
gs-3960	213	2	n	n	PRON
gs-3960	213	3	3	3	NUM
gs-3960	213	4	,	,	PUNCT
gs-3960	213	5	2025	2025	NUM
gs-3960	213	6	411	411	NUM
gs-3960	213	7	the	the	DET
gs-3960	213	8	features	feature	NOUN
gs-3960	213	9	of	of	ADP
gs-3960	213	10	nad+	nad+	PROPN
gs-3960	213	11	metabolism	metabolism	NOUN
gs-3960	213	12	and	and	CCONJ
gs-3960	213	13	mitochondrial	mitochondrial	ADJ
gs-3960	213	14	resilience	resilience	NOUN
gs-3960	213	15	our	our	PRON
gs-3960	213	16	metabolomic	metabolomic	ADJ
gs-3960	213	17	profiling	profiling	NOUN
gs-3960	213	18	revealed	reveal	VERB
gs-3960	213	19	a	a	DET
gs-3960	213	20	striking	striking	ADJ
gs-3960	213	21	depletion	depletion	NOUN
gs-3960	213	22	of	of	ADP
gs-3960	213	23	the	the	DET
gs-3960	213	24	nad+	nad+	PROPN
gs-3960	213	25	metabolome	metabolome	NOUN
gs-3960	213	26	in	in	ADP
gs-3960	213	27	parkinson	parkinson	NOUN
gs-3960	213	28	's	's	PART
gs-3960	213	29	patients	patient	NOUN
gs-3960	213	30	,	,	PUNCT
gs-3960	213	31	with	with	ADP
gs-3960	213	32	nad+	nad+	PROPN
gs-3960	213	33	levels	level	NOUN
gs-3960	213	34	reduced	reduce	VERB
gs-3960	213	35	by	by	ADP
gs-3960	213	36	an	an	DET
gs-3960	213	37	average	average	NOUN
gs-3960	213	38	of	of	ADP
gs-3960	213	39	55	55	NUM
gs-3960	213	40	%	%	NOUN
gs-3960	213	41	in	in	ADP
gs-3960	213	42	the	the	DET
gs-3960	213	43	substantia	substantia	NOUN
gs-3960	213	44	nigra	nigra	NOUN
gs-3960	213	45	compared	compare	VERB
gs-3960	213	46	to	to	ADP
gs-3960	213	47	controls	control	NOUN
gs-3960	213	48	.	.	PUNCT
gs-3960	214	1	this	this	DET
gs-3960	214	2	depletion	depletion	NOUN
gs-3960	214	3	was	be	AUX
gs-3960	214	4	accompanied	accompany	VERB
gs-3960	214	5	by	by	ADP
gs-3960	214	6	a	a	DET
gs-3960	214	7	compensatory	compensatory	ADJ
gs-3960	214	8	upregulation	upregulation	NOUN
gs-3960	214	9	(	(	PUNCT
gs-3960	214	10	2.3	2.3	NUM
gs-3960	214	11	-	-	NUM
gs-3960	214	12	fold	fold	ADJ
gs-3960	214	13	)	)	PUNCT
gs-3960	214	14	of	of	ADP
gs-3960	214	15	the	the	DET
gs-3960	214	16	nad+	nad+	PROPN
gs-3960	214	17	salvage	salvage	NOUN
gs-3960	214	18	pathway	pathway	NOUN
gs-3960	214	19	enzyme	enzyme	NOUN
gs-3960	214	20	nampt	nampt	ADJ
gs-3960	214	21	,	,	PUNCT
gs-3960	214	22	suggesting	suggest	VERB
gs-3960	214	23	the	the	DET
gs-3960	214	24	neurons	neuron	NOUN
gs-3960	214	25	were	be	AUX
gs-3960	214	26	attempting	attempt	VERB
gs-3960	214	27	to	to	PART
gs-3960	214	28	maintain	maintain	VERB
gs-3960	214	29	nad+	nad+	NOUN
gs-3960	214	30	homeostasis	homeostasis	NOUN
gs-3960	214	31	despite	despite	SCONJ
gs-3960	214	32	severe	severe	ADJ
gs-3960	214	33	metabolic	metabolic	NOUN
gs-3960	214	34	stress	stress	NOUN
gs-3960	214	35	.	.	PUNCT
gs-3960	215	1	through	through	ADP
gs-3960	215	2	isotopic	isotopic	ADJ
gs-3960	215	3	tracer	tracer	NOUN
gs-3960	215	4	studies	study	NOUN
gs-3960	215	5	,	,	PUNCT
gs-3960	215	6	we	we	PRON
gs-3960	215	7	demonstrated	demonstrate	VERB
gs-3960	215	8	that	that	SCONJ
gs-3960	215	9	the	the	DET
gs-3960	215	10	nad+	nad+	PROPN
gs-3960	215	11	deficit	deficit	NOUN
gs-3960	215	12	primarily	primarily	ADV
gs-3960	215	13	stems	stem	VERB
gs-3960	215	14	from	from	ADP
gs-3960	215	15	three	three	NUM
gs-3960	215	16	factors	factor	NOUN
gs-3960	215	17	:	:	PUNCT
gs-3960	215	18	increased	increase	VERB
gs-3960	215	19	parp	parp	ADJ
gs-3960	215	20	activation	activation	NOUN
gs-3960	215	21	due	due	ADP
gs-3960	215	22	to	to	ADP
gs-3960	215	23	dna	dna	PROPN
gs-3960	215	24	damage	damage	NOUN
gs-3960	215	25	(	(	PUNCT
gs-3960	215	26	accounting	account	VERB
gs-3960	215	27	for	for	ADP
gs-3960	215	28	42	42	NUM
gs-3960	215	29	%	%	NOUN
gs-3960	215	30	of	of	ADP
gs-3960	215	31	nad+	nad+	PROPN
gs-3960	215	32	consumption	consumption	NOUN
gs-3960	215	33	)	)	PUNCT
gs-3960	215	34	,	,	PUNCT
gs-3960	215	35	elevated	elevate	VERB
gs-3960	215	36	cd38	cd38	PROPN
gs-3960	215	37	activity	activity	NOUN
gs-3960	215	38	(	(	PUNCT
gs-3960	215	39	responsible	responsible	ADJ
gs-3960	215	40	for	for	ADP
gs-3960	215	41	31	31	NUM
gs-3960	215	42	%	%	NOUN
gs-3960	215	43	of	of	ADP
gs-3960	215	44	depletion	depletion	NOUN
gs-3960	215	45	)	)	PUNCT
gs-3960	215	46	,	,	PUNCT
gs-3960	215	47	and	and	CCONJ
gs-3960	215	48	impaired	impaired	ADJ
gs-3960	215	49	recycling	recycling	NOUN
gs-3960	215	50	via	via	ADP
gs-3960	215	51	the	the	DET
gs-3960	215	52	salvage	salvage	NOUN
gs-3960	215	53	pathway	pathway	NOUN
gs-3960	215	54	(	(	PUNCT
gs-3960	215	55	27	27	NUM
gs-3960	215	56	%	%	NOUN
gs-3960	215	57	)	)	PUNCT
gs-3960	215	58	.	.	PUNCT
gs-3960	216	1	the	the	DET
gs-3960	216	2	functional	functional	ADJ
gs-3960	216	3	consequences	consequence	NOUN
gs-3960	216	4	of	of	ADP
gs-3960	216	5	nad+	nad+	PROPN
gs-3960	216	6	depletion	depletion	NOUN
gs-3960	216	7	were	be	AUX
gs-3960	216	8	examined	examine	VERB
gs-3960	216	9	using	use	VERB
gs-3960	216	10	electrophysiological	electrophysiological	ADJ
gs-3960	216	11	recordings	recording	NOUN
gs-3960	216	12	in	in	ADP
gs-3960	216	13	ipsc	ipsc	NOUN
gs-3960	216	14	-	-	PUNCT
gs-3960	216	15	derived	derive	VERB
gs-3960	216	16	dopaminergic	dopaminergic	ADJ
gs-3960	216	17	neurons	neuron	NOUN
gs-3960	216	18	.	.	PUNCT
gs-3960	217	1	nad+-deficient	nad+-deficient	NUM
gs-3960	217	2	neurons	neuron	NOUN
gs-3960	217	3	exhibited	exhibit	VERB
gs-3960	217	4	a	a	DET
gs-3960	217	5	68	68	NUM
gs-3960	217	6	%	%	NOUN
gs-3960	217	7	reduction	reduction	NOUN
gs-3960	217	8	in	in	ADP
gs-3960	217	9	spontaneous	spontaneous	ADJ
gs-3960	217	10	firing	firing	NOUN
gs-3960	217	11	frequency	frequency	NOUN
gs-3960	217	12	and	and	CCONJ
gs-3960	217	13	showed	show	VERB
gs-3960	217	14	marked	mark	VERB
gs-3960	217	15	instability	instability	NOUN
gs-3960	217	16	in	in	ADP
gs-3960	217	17	maintaining	maintain	VERB
gs-3960	217	18	membrane	membrane	NOUN
gs-3960	217	19	potentials	potential	NOUN
gs-3960	217	20	during	during	ADP
gs-3960	217	21	sustained	sustained	ADJ
gs-3960	217	22	depolarization	depolarization	NOUN
gs-3960	217	23	.	.	PUNCT
gs-3960	218	1	these	these	DET
gs-3960	218	2	electrophysiological	electrophysiological	ADJ
gs-3960	218	3	deficits	deficit	NOUN
gs-3960	218	4	were	be	AUX
gs-3960	218	5	completely	completely	ADV
gs-3960	218	6	reversed	reverse	VERB
gs-3960	218	7	by	by	ADP
gs-3960	218	8	72	72	NUM
gs-3960	218	9	-	-	PUNCT
gs-3960	218	10	hour	hour	NOUN
gs-3960	218	11	treatment	treatment	NOUN
gs-3960	218	12	with	with	ADP
gs-3960	218	13	1	1	NUM
gs-3960	218	14	mm	mm	NOUN
gs-3960	218	15	nicotinamide	nicotinamide	NOUN
gs-3960	218	16	riboside	riboside	NOUN
gs-3960	218	17	,	,	PUNCT
gs-3960	218	18	which	which	PRON
gs-3960	218	19	restored	restore	VERB
gs-3960	218	20	nad+	nad+	PROPN
gs-3960	218	21	levels	level	NOUN
gs-3960	218	22	to	to	ADP
gs-3960	218	23	89	89	NUM
gs-3960	218	24	%	%	NOUN
gs-3960	218	25	of	of	ADP
gs-3960	218	26	control	control	NOUN
gs-3960	218	27	values	value	NOUN
gs-3960	218	28	.	.	PUNCT
gs-3960	219	1	importantly	importantly	ADV
gs-3960	219	2	,	,	PUNCT
gs-3960	219	3	nad+	nad+	PROPN
gs-3960	219	4	repletion	repletion	NOUN
gs-3960	219	5	not	not	PART
gs-3960	219	6	only	only	ADV
gs-3960	219	7	improved	improve	VERB
gs-3960	219	8	electrical	electrical	ADJ
gs-3960	219	9	properties	property	NOUN
gs-3960	219	10	but	but	CCONJ
gs-3960	219	11	also	also	ADV
gs-3960	219	12	enhanced	enhance	VERB
gs-3960	219	13	mitochondrial	mitochondrial	ADJ
gs-3960	219	14	respiration	respiration	NOUN
gs-3960	219	15	by	by	ADP
gs-3960	219	16	2.1	2.1	NUM
gs-3960	219	17	-	-	NUM
gs-3960	219	18	fold	fold	ADJ
gs-3960	219	19	and	and	CCONJ
gs-3960	219	20	reduced	reduce	VERB
gs-3960	219	21	oxidative	oxidative	ADJ
gs-3960	219	22	stress	stress	NOUN
gs-3960	219	23	markers	marker	NOUN
gs-3960	219	24	by	by	ADP
gs-3960	219	25	73	73	NUM
gs-3960	219	26	%	%	NOUN
gs-3960	219	27	.	.	PUNCT
gs-3960	220	1	the	the	DET
gs-3960	220	2	interplay	interplay	NOUN
gs-3960	220	3	between	between	ADP
gs-3960	220	4	mitophagy	mitophagy	NOUN
gs-3960	220	5	and	and	CCONJ
gs-3960	220	6	nad+	nad+	NOUN
gs-3960	220	7	our	our	PRON
gs-3960	220	8	most	most	ADV
gs-3960	220	9	significant	significant	ADJ
gs-3960	220	10	finding	finding	NOUN
gs-3960	220	11	reveals	reveal	VERB
gs-3960	220	12	a	a	DET
gs-3960	220	13	previously	previously	ADV
gs-3960	220	14	unrecognized	unrecognize	VERB
gs-3960	220	15	feedback	feedback	NOUN
gs-3960	220	16	loop	loop	NOUN
gs-3960	220	17	between	between	ADP
gs-3960	220	18	mitophagy	mitophagy	NOUN
gs-3960	220	19	and	and	CCONJ
gs-3960	220	20	nad+	nad+	PROPN
gs-3960	220	21	metabolism	metabolism	NOUN
gs-3960	220	22	.	.	PUNCT
gs-3960	221	1	using	use	VERB
gs-3960	221	2	crispr	crispr	NOUN
gs-3960	221	3	-	-	PUNCT
gs-3960	221	4	interference	interference	NOUN
gs-3960	221	5	to	to	PART
gs-3960	221	6	selectively	selectively	ADV
gs-3960	221	7	inhibit	inhibit	VERB
gs-3960	221	8	either	either	CCONJ
gs-3960	221	9	pathway	pathway	NOUN
gs-3960	221	10	,	,	PUNCT
gs-3960	221	11	we	we	PRON
gs-3960	221	12	discovered	discover	VERB
gs-3960	221	13	that	that	SCONJ
gs-3960	221	14	nad+	nad+	PROPN
gs-3960	221	15	depletion	depletion	NOUN
gs-3960	221	16	reduces	reduce	VERB
gs-3960	221	17	mitophagy	mitophagy	NOUN
gs-3960	221	18	flux	flux	NOUN
gs-3960	221	19	by	by	ADP
gs-3960	221	20	58	58	NUM
gs-3960	221	21	%	%	NOUN
gs-3960	221	22	,	,	PUNCT
gs-3960	221	23	while	while	SCONJ
gs-3960	221	24	impaired	impaired	ADJ
gs-3960	221	25	mitophagy	mitophagy	NOUN
gs-3960	221	26	leads	lead	VERB
gs-3960	221	27	to	to	ADP
gs-3960	221	28	a	a	DET
gs-3960	221	29	43	43	NUM
gs-3960	221	30	%	%	NOUN
gs-3960	221	31	decrease	decrease	NOUN
gs-3960	221	32	in	in	ADP
gs-3960	221	33	nad+	nad+	PROPN
gs-3960	221	34	levels	level	NOUN
gs-3960	221	35	within	within	ADP
gs-3960	221	36	seven	seven	NUM
gs-3960	221	37	days	day	NOUN
gs-3960	221	38	.	.	PUNCT
gs-3960	222	1	this	this	DET
gs-3960	222	2	vicious	vicious	ADJ
gs-3960	222	3	cycle	cycle	NOUN
gs-3960	222	4	appears	appear	VERB
gs-3960	222	5	mediated	mediate	VERB
gs-3960	222	6	through	through	ADP
gs-3960	222	7	several	several	ADJ
gs-3960	222	8	mechanisms	mechanism	NOUN
gs-3960	222	9	:	:	PUNCT
gs-3960	222	10	(	(	PUNCT
gs-3960	222	11	1	1	X
gs-3960	222	12	)	)	PUNCT
gs-3960	222	13	nad+-dependent	nad+-dependent	NOUN
gs-3960	222	14	sirtuin	sirtuin	NOUN
gs-3960	222	15	deacetylation	deacetylation	NOUN
gs-3960	222	16	of	of	ADP
gs-3960	222	17	pink1	pink1	NOUN
gs-3960	222	18	is	be	AUX
gs-3960	222	19	required	require	VERB
gs-3960	222	20	for	for	ADP
gs-3960	222	21	its	its	PRON
gs-3960	222	22	mitochondrial	mitochondrial	ADJ
gs-3960	222	23	stabilization	stabilization	NOUN
gs-3960	222	24	,	,	PUNCT
gs-3960	222	25	(	(	PUNCT
gs-3960	222	26	2	2	X
gs-3960	222	27	)	)	PUNCT
gs-3960	222	28	mitophagy	mitophagy	NOUN
gs-3960	222	29	maintains	maintain	VERB
gs-3960	222	30	nad+	nad+	PROPN
gs-3960	222	31	levels	level	NOUN
gs-3960	222	32	by	by	ADP
gs-3960	222	33	removing	remove	VERB
gs-3960	222	34	mitochondria	mitochondria	NOUN
gs-3960	222	35	that	that	SCONJ
gs-3960	222	36	excessively	excessively	ADV
gs-3960	222	37	consume	consume	VERB
gs-3960	222	38	nad+	nad+	PROPN
gs-3960	222	39	through	through	ADP
gs-3960	222	40	parp	parp	ADJ
gs-3960	222	41	-	-	PUNCT
gs-3960	222	42	independent	independent	ADJ
gs-3960	222	43	mechanisms	mechanism	NOUN
gs-3960	222	44	,	,	PUNCT
gs-3960	222	45	and	and	CCONJ
gs-3960	222	46	(	(	PUNCT
gs-3960	222	47	3	3	X
gs-3960	222	48	)	)	PUNCT
gs-3960	222	49	healthy	healthy	ADJ
gs-3960	222	50	mitochondria	mitochondria	NOUN
gs-3960	222	51	generated	generate	VERB
gs-3960	222	52	through	through	ADP
gs-3960	222	53	efficient	efficient	ADJ
gs-3960	222	54	mitophagy	mitophagy	NOUN
gs-3960	222	55	are	be	AUX
gs-3960	222	56	required	require	VERB
gs-3960	222	57	for	for	ADP
gs-3960	222	58	nad+	nad+	NOUN
gs-3960	222	59	biosynthesis	biosynthesis	NOUN
gs-3960	222	60	from	from	ADP
gs-3960	222	61	tryptophan	tryptophan	NOUN
gs-3960	222	62	.	.	PUNCT
gs-3960	223	1	this	this	DET
gs-3960	223	2	interdependence	interdependence	NOUN
gs-3960	223	3	has	have	VERB
gs-3960	223	4	crucial	crucial	ADJ
gs-3960	223	5	therapeutic	therapeutic	ADJ
gs-3960	223	6	implications	implication	NOUN
gs-3960	223	7	.	.	PUNCT
gs-3960	224	1	in	in	ADP
gs-3960	224	2	animal	animal	NOUN
gs-3960	224	3	models	model	NOUN
gs-3960	224	4	,	,	PUNCT
gs-3960	224	5	combined	combined	ADJ
gs-3960	224	6	treatment	treatment	NOUN
gs-3960	224	7	with	with	ADP
gs-3960	224	8	a	a	DET
gs-3960	224	9	mitophagy	mitophagy	NOUN
gs-3960	224	10	enhancer	enhancer	NOUN
gs-3960	224	11	(	(	PUNCT
gs-3960	224	12	urolithin	urolithin	PROPN
gs-3960	224	13	a	a	X
gs-3960	224	14	)	)	PUNCT
gs-3960	224	15	and	and	CCONJ
gs-3960	224	16	nad+	nad+	PROPN
gs-3960	224	17	precursor	precursor	NOUN
gs-3960	224	18	(	(	PUNCT
gs-3960	224	19	nicotinamide	nicotinamide	NOUN
gs-3960	224	20	mononucleotide	mononucleotide	NOUN
gs-3960	224	21	)	)	PUNCT
gs-3960	224	22	produced	produce	VERB
gs-3960	224	23	synergistic	synergistic	ADJ
gs-3960	224	24	effects	effect	NOUN
gs-3960	224	25	,	,	PUNCT
gs-3960	224	26	with	with	ADP
gs-3960	224	27	the	the	DET
gs-3960	224	28	combination	combination	NOUN
gs-3960	224	29	therapy	therapy	NOUN
gs-3960	224	30	showing	show	VERB
gs-3960	224	31	3.2	3.2	NUM
gs-3960	224	32	-	-	NOUN
gs-3960	224	33	fold	fold	VERB
gs-3960	224	34	greater	great	ADJ
gs-3960	224	35	neuroprotection	neuroprotection	NOUN
gs-3960	224	36	than	than	ADP
gs-3960	224	37	either	either	DET
gs-3960	224	38	treatment	treatment	NOUN
gs-3960	224	39	alone	alone	ADV
gs-3960	224	40	.	.	PUNCT
gs-3960	225	1	microdialysis	microdialysis	NOUN
gs-3960	225	2	in	in	ADP
gs-3960	225	3	these	these	DET
gs-3960	225	4	animals	animal	NOUN
gs-3960	225	5	revealed	reveal	VERB
gs-3960	225	6	that	that	SCONJ
gs-3960	225	7	the	the	DET
gs-3960	225	8	combination	combination	NOUN
gs-3960	225	9	restored	restore	VERB
gs-3960	225	10	striatal	striatal	ADJ
gs-3960	225	11	dopamine	dopamine	NOUN
gs-3960	225	12	levels	level	NOUN
gs-3960	225	13	to	to	ADP
gs-3960	225	14	92	92	NUM
gs-3960	225	15	%	%	NOUN
gs-3960	225	16	of	of	ADP
gs-3960	225	17	normal	normal	ADJ
gs-3960	225	18	,	,	PUNCT
gs-3960	225	19	compared	compare	VERB
gs-3960	225	20	to	to	ADP
gs-3960	225	21	68	68	NUM
gs-3960	225	22	%	%	NOUN
gs-3960	225	23	with	with	ADP
gs-3960	225	24	single	single	ADJ
gs-3960	225	25	treatments	treatment	NOUN
gs-3960	225	26	.	.	PUNCT
gs-3960	226	1	these	these	DET
gs-3960	226	2	findings	finding	NOUN
gs-3960	226	3	suggest	suggest	VERB
gs-3960	226	4	that	that	SCONJ
gs-3960	226	5	targeting	target	VERB
gs-3960	226	6	both	both	DET
gs-3960	226	7	pathways	pathway	NOUN
gs-3960	226	8	simultaneously	simultaneously	ADV
gs-3960	226	9	may	may	AUX
gs-3960	226	10	be	be	AUX
gs-3960	226	11	necessary	necessary	ADJ
gs-3960	226	12	for	for	ADP
gs-3960	226	13	optimal	optimal	ADJ
gs-3960	226	14	therapeutic	therapeutic	ADJ
gs-3960	226	15	outcomes	outcome	NOUN
gs-3960	227	1	[	[	X
gs-3960	227	2	6,18,29,75	6,18,29,75	NOUN
gs-3960	227	3	]	]	X
gs-3960	227	4	.	.	PUNCT
gs-3960	228	1	georgian	georgian	NOUN
gs-3960	228	2	scientists/	scientists/	NUM
gs-3960	228	3	.	.	PUNCT
gs-3960	229	1	7	7	NUM
gs-3960	229	2	n	n	PRON
gs-3960	229	3	3	3	NUM
gs-3960	229	4	,	,	PUNCT
gs-3960	229	5	2025	2025	NUM
gs-3960	229	6	412	412	NUM
gs-3960	230	1	our	our	PRON
gs-3960	230	2	analysis	analysis	NOUN
gs-3960	230	3	of	of	ADP
gs-3960	230	4	current	current	ADJ
gs-3960	230	5	clinical	clinical	ADJ
gs-3960	230	6	trials	trial	NOUN
gs-3960	230	7	reveals	reveal	VERB
gs-3960	230	8	both	both	CCONJ
gs-3960	230	9	promise	promise	NOUN
gs-3960	230	10	and	and	CCONJ
gs-3960	230	11	limitations	limitation	NOUN
gs-3960	230	12	in	in	ADP
gs-3960	230	13	translating	translate	VERB
gs-3960	230	14	these	these	DET
gs-3960	230	15	findings	finding	NOUN
gs-3960	230	16	to	to	ADP
gs-3960	230	17	human	human	ADJ
gs-3960	230	18	therapy	therapy	NOUN
gs-3960	230	19	.	.	PUNCT
gs-3960	231	1	phase	phase	NOUN
gs-3960	231	2	ii	ii	PROPN
gs-3960	231	3	trials	trial	NOUN
gs-3960	231	4	of	of	ADP
gs-3960	231	5	nad+	nad+	PROPN
gs-3960	231	6	precursors	precursor	NOUN
gs-3960	231	7	show	show	VERB
gs-3960	231	8	modest	modest	ADJ
gs-3960	231	9	but	but	CCONJ
gs-3960	231	10	significant	significant	ADJ
gs-3960	231	11	improvements	improvement	NOUN
gs-3960	231	12	in	in	ADP
gs-3960	231	13	unified	unified	ADJ
gs-3960	231	14	parkinson	parkinson	NOUN
gs-3960	231	15	's	's	PART
gs-3960	231	16	disease	disease	NOUN
gs-3960	231	17	rating	rating	NOUN
gs-3960	231	18	scale	scale	NOUN
gs-3960	231	19	(	(	PUNCT
gs-3960	231	20	updrs	updrs	PROPN
gs-3960	231	21	)	)	PUNCT
gs-3960	231	22	scores	score	NOUN
gs-3960	231	23	(	(	PUNCT
gs-3960	231	24	average	average	ADJ
gs-3960	231	25	4.7	4.7	NUM
gs-3960	231	26	point	point	NOUN
gs-3960	231	27	improvement	improvement	NOUN
gs-3960	231	28	versus	versus	ADP
gs-3960	231	29	placebo	placebo	NOUN
gs-3960	231	30	)	)	PUNCT
gs-3960	231	31	,	,	PUNCT
gs-3960	231	32	particularly	particularly	ADV
gs-3960	231	33	in	in	ADP
gs-3960	231	34	patients	patient	NOUN
gs-3960	231	35	with	with	ADP
gs-3960	231	36	milder	mild	ADJ
gs-3960	231	37	disease	disease	NOUN
gs-3960	231	38	.	.	PUNCT
gs-3960	232	1	however	however	ADV
gs-3960	232	2	,	,	PUNCT
gs-3960	232	3	pharmacokinetic	pharmacokinetic	ADJ
gs-3960	232	4	studies	study	NOUN
gs-3960	232	5	demonstrate	demonstrate	VERB
gs-3960	232	6	that	that	SCONJ
gs-3960	232	7	only	only	ADV
gs-3960	232	8	0.2	0.2	NUM
gs-3960	232	9	%	%	NOUN
gs-3960	232	10	of	of	ADP
gs-3960	232	11	orally	orally	ADV
gs-3960	232	12	administered	administer	VERB
gs-3960	232	13	nad+	nad+	PROPN
gs-3960	232	14	precursors	precursor	NOUN
gs-3960	232	15	reach	reach	VERB
gs-3960	232	16	the	the	DET
gs-3960	232	17	brain	brain	NOUN
gs-3960	232	18	,	,	PUNCT
gs-3960	232	19	highlighting	highlight	VERB
gs-3960	232	20	a	a	DET
gs-3960	232	21	critical	critical	ADJ
gs-3960	232	22	delivery	delivery	NOUN
gs-3960	232	23	challenge	challenge	NOUN
gs-3960	232	24	.	.	PUNCT
gs-3960	233	1	we	we	PRON
gs-3960	233	2	've	have	AUX
gs-3960	233	3	identified	identify	VERB
gs-3960	233	4	that	that	DET
gs-3960	233	5	concurrent	concurrent	ADJ
gs-3960	233	6	administration	administration	NOUN
gs-3960	233	7	with	with	ADP
gs-3960	233	8	inhibitors	inhibitor	NOUN
gs-3960	233	9	of	of	ADP
gs-3960	233	10	the	the	DET
gs-3960	233	11	nad+	nad+	X
gs-3960	233	12	consuming	consume	VERB
gs-3960	233	13	enzyme	enzyme	NOUN
gs-3960	233	14	cd38	cd38	PROPN
gs-3960	233	15	can	can	AUX
gs-3960	233	16	increase	increase	VERB
gs-3960	233	17	central	central	ADJ
gs-3960	233	18	nad+	nad+	PROPN
gs-3960	233	19	levels	level	NOUN
gs-3960	233	20	by	by	ADP
gs-3960	233	21	3.8	3.8	NUM
gs-3960	233	22	-	-	ADJ
gs-3960	233	23	fold	fold	NOUN
gs-3960	233	24	compared	compare	VERB
gs-3960	233	25	to	to	ADP
gs-3960	233	26	precursor	precursor	NOUN
gs-3960	233	27	administration	administration	NOUN
gs-3960	233	28	alone	alone	ADV
gs-3960	233	29	.	.	PUNCT
gs-3960	234	1	for	for	ADP
gs-3960	234	2	mitophagy	mitophagy	NOUN
gs-3960	234	3	enhancement	enhancement	NOUN
gs-3960	234	4	,	,	PUNCT
gs-3960	234	5	the	the	DET
gs-3960	234	6	blood	blood	NOUN
gs-3960	234	7	-	-	PUNCT
gs-3960	234	8	brain	brain	NOUN
gs-3960	234	9	barrier	barrier	NOUN
gs-3960	234	10	presents	present	VERB
gs-3960	234	11	an	an	DET
gs-3960	234	12	even	even	ADV
gs-3960	234	13	greater	great	ADJ
gs-3960	234	14	obstacle	obstacle	NOUN
gs-3960	234	15	.	.	PUNCT
gs-3960	235	1	our	our	PRON
gs-3960	235	2	nanoparticle	nanoparticle	NOUN
gs-3960	235	3	delivery	delivery	NOUN
gs-3960	235	4	system	system	NOUN
gs-3960	235	5	,	,	PUNCT
gs-3960	235	6	incorporating	incorporate	VERB
gs-3960	235	7	pink1	pink1	NOUN
gs-3960	235	8	mrna	mrna	NOUN
gs-3960	235	9	in	in	ADP
gs-3960	235	10	lipid	lipid	ADJ
gs-3960	235	11	nanoparticles	nanoparticle	NOUN
gs-3960	235	12	,	,	PUNCT
gs-3960	235	13	achieved	achieve	VERB
gs-3960	235	14	47	47	NUM
gs-3960	235	15	%	%	NOUN
gs-3960	235	16	transfection	transfection	NOUN
gs-3960	235	17	efficiency	efficiency	NOUN
gs-3960	235	18	in	in	ADP
gs-3960	235	19	non	non	ADJ
gs-3960	235	20	-	-	ADJ
gs-3960	235	21	human	human	ADJ
gs-3960	235	22	primate	primate	NOUN
gs-3960	235	23	substantia	substantia	NOUN
gs-3960	235	24	nigra	nigra	NOUN
gs-3960	235	25	neurons	neuron	NOUN
gs-3960	235	26	,	,	PUNCT
gs-3960	235	27	with	with	ADP
gs-3960	235	28	sustained	sustained	ADJ
gs-3960	235	29	pink1	pink1	NOUN
gs-3960	235	30	expression	expression	NOUN
gs-3960	235	31	for	for	ADP
gs-3960	235	32	28	28	NUM
gs-3960	235	33	days	day	NOUN
gs-3960	235	34	.	.	PUNCT
gs-3960	236	1	this	this	DET
gs-3960	236	2	approach	approach	NOUN
gs-3960	236	3	restored	restore	VERB
gs-3960	236	4	mitophagy	mitophagy	NOUN
gs-3960	236	5	markers	marker	NOUN
gs-3960	236	6	to	to	ADP
gs-3960	236	7	81	81	NUM
gs-3960	236	8	%	%	NOUN
gs-3960	236	9	of	of	ADP
gs-3960	236	10	normal	normal	ADJ
gs-3960	236	11	levels	level	NOUN
gs-3960	236	12	in	in	ADP
gs-3960	236	13	mptp	mptp	PROPN
gs-3960	236	14	-	-	PUNCT
gs-3960	236	15	treated	treat	VERB
gs-3960	236	16	monkeys	monkey	NOUN
gs-3960	236	17	and	and	CCONJ
gs-3960	236	18	reduced	reduce	VERB
gs-3960	236	19	motor	motor	NOUN
gs-3960	236	20	symptoms	symptom	NOUN
gs-3960	236	21	by	by	ADP
gs-3960	236	22	62	62	NUM
gs-3960	236	23	%	%	NOUN
gs-3960	236	24	on	on	ADP
gs-3960	236	25	primate	primate	NOUN
gs-3960	236	26	rating	rating	NOUN
gs-3960	236	27	scales	scale	NOUN
gs-3960	236	28	.	.	PUNCT
gs-3960	237	1	single	single	ADJ
gs-3960	237	2	-	-	PUNCT
gs-3960	237	3	nucleus	nucleus	NOUN
gs-3960	237	4	rna	rna	NOUN
gs-3960	237	5	sequencing	sequencing	NOUN
gs-3960	237	6	of	of	ADP
gs-3960	237	7	patient	patient	ADJ
gs-3960	237	8	neurons	neuron	NOUN
gs-3960	237	9	has	have	AUX
gs-3960	237	10	revealed	reveal	VERB
gs-3960	237	11	three	three	NUM
gs-3960	237	12	distinct	distinct	ADJ
gs-3960	237	13	subtypes	subtype	NOUN
gs-3960	237	14	of	of	ADP
gs-3960	237	15	mitochondrial	mitochondrial	ADJ
gs-3960	237	16	dysfunction	dysfunction	NOUN
gs-3960	237	17	in	in	ADP
gs-3960	237	18	parkinson	parkinson	NOUN
gs-3960	237	19	's	's	PART
gs-3960	237	20	:	:	PUNCT
gs-3960	237	21	(	(	PUNCT
gs-3960	237	22	1	1	X
gs-3960	237	23	)	)	PUNCT
gs-3960	237	24	primary	primary	ADJ
gs-3960	237	25	mitophagy	mitophagy	NOUN
gs-3960	237	26	failure	failure	NOUN
gs-3960	237	27	(	(	PUNCT
gs-3960	237	28	32	32	NUM
gs-3960	237	29	%	%	NOUN
gs-3960	237	30	of	of	ADP
gs-3960	237	31	cases	case	NOUN
gs-3960	237	32	)	)	PUNCT
gs-3960	237	33	,	,	PUNCT
gs-3960	237	34	(	(	PUNCT
gs-3960	237	35	2	2	X
gs-3960	237	36	)	)	PUNCT
gs-3960	237	37	nad+	nad+	PROPN
gs-3960	237	38	metabolism	metabolism	NOUN
gs-3960	237	39	deficit	deficit	NOUN
gs-3960	237	40	(	(	PUNCT
gs-3960	237	41	41	41	NUM
gs-3960	237	42	%	%	NOUN
gs-3960	237	43	)	)	PUNCT
gs-3960	237	44	,	,	PUNCT
gs-3960	237	45	and	and	CCONJ
gs-3960	237	46	(	(	PUNCT
gs-3960	237	47	3	3	X
gs-3960	237	48	)	)	PUNCT
gs-3960	237	49	combined	combine	VERB
gs-3960	237	50	pathway	pathway	NOUN
gs-3960	237	51	impairment	impairment	NOUN
gs-3960	237	52	(	(	PUNCT
gs-3960	237	53	27	27	NUM
gs-3960	237	54	%	%	NOUN
gs-3960	237	55	)	)	PUNCT
gs-3960	237	56	.	.	PUNCT
gs-3960	238	1	this	this	DET
gs-3960	238	2	stratification	stratification	NOUN
gs-3960	238	3	suggests	suggest	VERB
gs-3960	238	4	that	that	SCONJ
gs-3960	238	5	personalized	personalized	ADJ
gs-3960	238	6	approaches	approach	NOUN
gs-3960	238	7	based	base	VERB
gs-3960	238	8	on	on	ADP
gs-3960	238	9	individual	individual	ADJ
gs-3960	238	10	metabolic	metabolic	NOUN
gs-3960	238	11	profiles	profile	NOUN
gs-3960	238	12	may	may	AUX
gs-3960	238	13	be	be	AUX
gs-3960	238	14	necessary	necessary	ADJ
gs-3960	238	15	.	.	PUNCT
gs-3960	239	1	our	our	PRON
gs-3960	239	2	preliminary	preliminary	ADJ
gs-3960	239	3	trial	trial	NOUN
gs-3960	239	4	of	of	ADP
gs-3960	239	5	phenotype	phenotype	NOUN
gs-3960	239	6	-	-	PUNCT
gs-3960	239	7	targeted	target	VERB
gs-3960	239	8	therapy	therapy	NOUN
gs-3960	239	9	shows	show	VERB
gs-3960	239	10	2.9	2.9	NUM
gs-3960	239	11	-	-	ADJ
gs-3960	239	12	fold	fold	VERB
gs-3960	239	13	better	well	ADJ
gs-3960	239	14	outcomes	outcome	NOUN
gs-3960	239	15	compared	compare	VERB
gs-3960	239	16	to	to	ADP
gs-3960	239	17	non	non	ADJ
gs-3960	239	18	-	-	ADJ
gs-3960	239	19	stratified	stratified	ADJ
gs-3960	239	20	treatment	treatment	NOUN
gs-3960	239	21	.	.	PUNCT
gs-3960	240	1	emerging	emerge	VERB
gs-3960	240	2	technologies	technology	NOUN
gs-3960	240	3	offer	offer	VERB
gs-3960	240	4	additional	additional	ADJ
gs-3960	240	5	promise	promise	NOUN
gs-3960	240	6	.	.	PUNCT
gs-3960	241	1	mitochondrial	mitochondrial	ADJ
gs-3960	241	2	transplantation	transplantation	NOUN
gs-3960	241	3	,	,	PUNCT
gs-3960	241	4	where	where	SCONJ
gs-3960	241	5	healthy	healthy	ADJ
gs-3960	241	6	mitochondria	mitochondria	NOUN
gs-3960	241	7	are	be	AUX
gs-3960	241	8	delivered	deliver	VERB
gs-3960	241	9	via	via	ADP
gs-3960	241	10	platelet	platelet	ADJ
gs-3960	241	11	-	-	PUNCT
gs-3960	241	12	derived	derive	VERB
gs-3960	241	13	carriers	carrier	NOUN
gs-3960	241	14	,	,	PUNCT
gs-3960	241	15	has	have	AUX
gs-3960	241	16	shown	show	VERB
gs-3960	241	17	remarkable	remarkable	ADJ
gs-3960	241	18	efficacy	efficacy	NOUN
gs-3960	241	19	in	in	ADP
gs-3960	241	20	rodent	rodent	ADJ
gs-3960	241	21	models	model	NOUN
gs-3960	241	22	,	,	PUNCT
gs-3960	241	23	with	with	ADP
gs-3960	241	24	engrafted	engraft	VERB
gs-3960	241	25	mitochondria	mitochondria	NOUN
gs-3960	241	26	persisting	persist	VERB
gs-3960	241	27	for	for	ADP
gs-3960	241	28	over	over	ADP
gs-3960	241	29	90	90	NUM
gs-3960	241	30	days	day	NOUN
gs-3960	241	31	and	and	CCONJ
gs-3960	241	32	restoring	restore	VERB
gs-3960	241	33	78	78	NUM
gs-3960	241	34	%	%	NOUN
gs-3960	241	35	of	of	ADP
gs-3960	241	36	normal	normal	ADJ
gs-3960	241	37	motor	motor	NOUN
gs-3960	241	38	function	function	NOUN
gs-3960	241	39	.	.	PUNCT
gs-3960	242	1	similarly	similarly	ADV
gs-3960	242	2	,	,	PUNCT
gs-3960	242	3	gene	gene	NOUN
gs-3960	242	4	therapy	therapy	NOUN
gs-3960	242	5	vectors	vector	NOUN
gs-3960	242	6	designed	design	VERB
gs-3960	242	7	to	to	PART
gs-3960	242	8	co	co	VERB
gs-3960	242	9	-	-	VERB
gs-3960	242	10	express	express	ADJ
gs-3960	242	11	pink1	pink1	NOUN
gs-3960	242	12	and	and	CCONJ
gs-3960	242	13	nampt	nampt	NOUN
gs-3960	242	14	are	be	AUX
gs-3960	242	15	currently	currently	ADV
gs-3960	242	16	in	in	ADP
gs-3960	242	17	preclinical	preclinical	ADJ
gs-3960	242	18	development	development	NOUN
gs-3960	242	19	,	,	PUNCT
gs-3960	242	20	showing	show	VERB
gs-3960	242	21	complete	complete	ADJ
gs-3960	242	22	prevention	prevention	NOUN
gs-3960	242	23	of	of	ADP
gs-3960	242	24	neurodegeneration	neurodegeneration	NOUN
gs-3960	242	25	in	in	ADP
gs-3960	242	26	genetic	genetic	ADJ
gs-3960	242	27	parkinson	parkinson	NOUN
gs-3960	242	28	's	's	PART
gs-3960	242	29	models	model	NOUN
gs-3960	242	30	[	[	X
gs-3960	242	31	8,19,77	8,19,77	NOUN
gs-3960	242	32	]	]	PUNCT
gs-3960	242	33	.	.	PUNCT
gs-3960	243	1	the	the	DET
gs-3960	243	2	complex	complex	ADJ
gs-3960	243	3	landscape	landscape	NOUN
gs-3960	243	4	of	of	ADP
gs-3960	243	5	mitochondrial	mitochondrial	ADJ
gs-3960	243	6	dysfunction	dysfunction	NOUN
gs-3960	243	7	in	in	ADP
gs-3960	243	8	parkinson	parkinson	NOUN
gs-3960	243	9	's	's	PART
gs-3960	243	10	disease	disease	NOUN
gs-3960	243	11	:	:	PUNCT
gs-3960	243	12	emerging	emerge	VERB
gs-3960	243	13	insights	insight	NOUN
gs-3960	243	14	and	and	CCONJ
gs-3960	243	15	therapeutic	therapeutic	ADJ
gs-3960	243	16	horizons	horizon	NOUN
gs-3960	243	17	the	the	DET
gs-3960	243	18	intricate	intricate	ADJ
gs-3960	243	19	relationship	relationship	NOUN
gs-3960	243	20	between	between	ADP
gs-3960	243	21	mitochondrial	mitochondrial	ADJ
gs-3960	243	22	health	health	NOUN
gs-3960	243	23	and	and	CCONJ
gs-3960	243	24	neuronal	neuronal	ADJ
gs-3960	243	25	survival	survival	NOUN
gs-3960	243	26	in	in	ADP
gs-3960	243	27	parkinson	parkinson	NOUN
gs-3960	243	28	's	's	PART
gs-3960	243	29	disease	disease	NOUN
gs-3960	243	30	continues	continue	VERB
gs-3960	243	31	to	to	PART
gs-3960	243	32	reveal	reveal	VERB
gs-3960	243	33	new	new	ADJ
gs-3960	243	34	layers	layer	NOUN
gs-3960	243	35	of	of	ADP
gs-3960	243	36	complexity	complexity	NOUN
gs-3960	243	37	as	as	ADP
gs-3960	243	38	research	research	NOUN
gs-3960	243	39	advances	advance	NOUN
gs-3960	243	40	.	.	PUNCT
gs-3960	244	1	recent	recent	ADJ
gs-3960	244	2	investigations	investigation	NOUN
gs-3960	244	3	have	have	AUX
gs-3960	244	4	uncovered	uncover	VERB
gs-3960	244	5	novel	novel	ADJ
gs-3960	244	6	aspects	aspect	NOUN
gs-3960	244	7	of	of	ADP
gs-3960	244	8	mitochondrial	mitochondrial	ADJ
gs-3960	244	9	biology	biology	NOUN
gs-3960	244	10	that	that	PRON
gs-3960	244	11	extend	extend	VERB
gs-3960	244	12	far	far	ADV
gs-3960	244	13	beyond	beyond	ADP
gs-3960	244	14	traditional	traditional	ADJ
gs-3960	244	15	views	view	NOUN
gs-3960	244	16	of	of	ADP
gs-3960	244	17	energy	energy	NOUN
gs-3960	244	18	production	production	NOUN
gs-3960	244	19	,	,	PUNCT
gs-3960	244	20	positioning	position	VERB
gs-3960	244	21	these	these	DET
gs-3960	244	22	organelles	organelle	NOUN
gs-3960	244	23	as	as	ADP
gs-3960	244	24	central	central	ADJ
gs-3960	244	25	regulators	regulator	NOUN
gs-3960	244	26	of	of	ADP
gs-3960	244	27	cellular	cellular	ADJ
gs-3960	244	28	fate	fate	NOUN
gs-3960	244	29	in	in	ADP
gs-3960	244	30	dopaminergic	dopaminergic	ADJ
gs-3960	244	31	neurons	neuron	NOUN
gs-3960	244	32	.	.	PUNCT
gs-3960	245	1	the	the	DET
gs-3960	245	2	emerging	emerge	VERB
gs-3960	245	3	picture	picture	NOUN
gs-3960	245	4	suggests	suggest	VERB
gs-3960	245	5	that	that	SCONJ
gs-3960	245	6	mitochondria	mitochondria	PROPN
gs-3960	245	7	serve	serve	VERB
gs-3960	245	8	as	as	ADP
gs-3960	245	9	dynamic	dynamic	ADJ
gs-3960	245	10	signaling	signal	VERB
gs-3960	245	11	hubs	hub	NOUN
gs-3960	245	12	that	that	PRON
gs-3960	245	13	integrate	integrate	VERB
gs-3960	245	14	metabolic	metabolic	NOUN
gs-3960	245	15	,	,	PUNCT
gs-3960	245	16	oxidative	oxidative	ADJ
gs-3960	245	17	,	,	PUNCT
gs-3960	245	18	and	and	CCONJ
gs-3960	245	19	proteostatic	proteostatic	ADJ
gs-3960	245	20	information	information	NOUN
gs-3960	245	21	to	to	PART
gs-3960	245	22	determine	determine	VERB
gs-3960	245	23	neuronal	neuronal	ADJ
gs-3960	245	24	vulnerability	vulnerability	NOUN
gs-3960	245	25	or	or	CCONJ
gs-3960	245	26	resilience	resilience	NOUN
gs-3960	245	27	in	in	ADP
gs-3960	245	28	the	the	DET
gs-3960	245	29	face	face	NOUN
gs-3960	245	30	of	of	ADP
gs-3960	245	31	parkinson	parkinson	NOUN
gs-3960	245	32	's	's	PART
gs-3960	245	33	pathology	pathology	NOUN
gs-3960	245	34	.	.	PUNCT
gs-3960	246	1	georgian	georgian	PROPN
gs-3960	246	2	scientists/	scientists/	NUM
gs-3960	246	3	.	.	PUNCT
gs-3960	247	1	7	7	NUM
gs-3960	247	2	n	n	PRON
gs-3960	247	3	3	3	NUM
gs-3960	247	4	,	,	PUNCT
gs-3960	247	5	2025	2025	NUM
gs-3960	247	6	413	413	NUM
gs-3960	247	7	mitochondrial	mitochondrial	ADJ
gs-3960	247	8	-	-	PUNCT
gs-3960	247	9	endoplasmic	endoplasmic	ADJ
gs-3960	247	10	reticulum	reticulum	NOUN
gs-3960	247	11	crosstalk	crosstalk	NOUN
gs-3960	247	12	in	in	ADP
gs-3960	247	13	neuronal	neuronal	ADJ
gs-3960	247	14	vulnerability	vulnerability	NOUN
gs-3960	247	15	a	a	DET
gs-3960	247	16	groundbreaking	groundbreake	VERB
gs-3960	247	17	area	area	NOUN
gs-3960	247	18	of	of	ADP
gs-3960	247	19	research	research	NOUN
gs-3960	247	20	has	have	AUX
gs-3960	247	21	illuminated	illuminate	VERB
gs-3960	247	22	the	the	DET
gs-3960	247	23	critical	critical	ADJ
gs-3960	247	24	importance	importance	NOUN
gs-3960	247	25	of	of	ADP
gs-3960	247	26	mitochondrial	mitochondrial	ADJ
gs-3960	247	27	-	-	PUNCT
gs-3960	247	28	associated	associate	VERB
gs-3960	247	29	membranes	membrane	NOUN
gs-3960	247	30	(	(	PUNCT
gs-3960	247	31	mams	mam	NOUN
gs-3960	247	32	)	)	PUNCT
gs-3960	247	33	in	in	ADP
gs-3960	247	34	parkinson	parkinson	NOUN
gs-3960	247	35	's	's	PART
gs-3960	247	36	disease	disease	NOUN
gs-3960	247	37	pathogenesis	pathogenesis	NOUN
gs-3960	247	38	.	.	PUNCT
gs-3960	248	1	these	these	DET
gs-3960	248	2	specialized	specialized	ADJ
gs-3960	248	3	contact	contact	NOUN
gs-3960	248	4	sites	site	NOUN
gs-3960	248	5	between	between	ADP
gs-3960	248	6	mitochondria	mitochondria	NOUN
gs-3960	248	7	and	and	CCONJ
gs-3960	248	8	the	the	DET
gs-3960	248	9	endoplasmic	endoplasmic	ADJ
gs-3960	248	10	reticulum	reticulum	NOUN
gs-3960	248	11	facilitate	facilitate	NOUN
gs-3960	248	12	calcium	calcium	NOUN
gs-3960	248	13	transfer	transfer	NOUN
gs-3960	248	14	,	,	PUNCT
gs-3960	248	15	lipid	lipid	NOUN
gs-3960	248	16	synthesis	synthesis	NOUN
gs-3960	248	17	,	,	PUNCT
gs-3960	248	18	and	and	CCONJ
gs-3960	248	19	apoptotic	apoptotic	ADJ
gs-3960	248	20	signaling	signaling	NOUN
gs-3960	248	21	.	.	PUNCT
gs-3960	249	1	studies	study	NOUN
gs-3960	249	2	using	use	VERB
gs-3960	249	3	super	super	ADJ
gs-3960	249	4	-	-	ADJ
gs-3960	249	5	resolution	resolution	NOUN
gs-3960	249	6	exhibit	exhibit	NOUN
gs-3960	249	7	significantly	significantly	ADV
gs-3960	249	8	altered	alter	VERB
gs-3960	249	9	mam	mam	NOUN
gs-3960	249	10	architecture	architecture	NOUN
gs-3960	249	11	,	,	PUNCT
gs-3960	249	12	with	with	ADP
gs-3960	249	13	contact	contact	NOUN
gs-3960	249	14	sites	site	NOUN
gs-3960	249	15	being	be	AUX
gs-3960	249	16	either	either	CCONJ
gs-3960	249	17	abnormally	abnormally	ADV
gs-3960	249	18	prolonged	prolonged	ADJ
gs-3960	249	19	or	or	CCONJ
gs-3960	249	20	excessively	excessively	ADV
gs-3960	249	21	fragmented	fragmented	ADJ
gs-3960	249	22	depending	depend	VERB
gs-3960	249	23	on	on	ADP
gs-3960	249	24	the	the	DET
gs-3960	249	25	genetic	genetic	ADJ
gs-3960	249	26	context	context	NOUN
gs-3960	249	27	.	.	PUNCT
gs-3960	250	1	this	this	DET
gs-3960	250	2	structural	structural	ADJ
gs-3960	250	3	disruption	disruption	NOUN
gs-3960	250	4	correlates	correlate	VERB
gs-3960	250	5	with	with	ADP
gs-3960	250	6	impaired	impaired	ADJ
gs-3960	250	7	calcium	calcium	NOUN
gs-3960	250	8	buffering	buffering	NOUN
gs-3960	250	9	capacity	capacity	NOUN
gs-3960	250	10	,	,	PUNCT
gs-3960	250	11	making	make	VERB
gs-3960	250	12	neurons	neuron	NOUN
gs-3960	250	13	more	more	ADV
gs-3960	250	14	susceptible	susceptible	ADJ
gs-3960	250	15	to	to	ADP
gs-3960	250	16	excitotoxic	excitotoxic	ADJ
gs-3960	250	17	insults	insult	NOUN
gs-3960	250	18	.	.	PUNCT
gs-3960	251	1	the	the	DET
gs-3960	251	2	protein	protein	NOUN
gs-3960	251	3	alpha	alpha	NOUN
gs-3960	251	4	-	-	PUNCT
gs-3960	251	5	synuclein	synuclein	NOUN
gs-3960	251	6	,	,	PUNCT
gs-3960	251	7	long	long	ADV
gs-3960	251	8	implicated	implicate	VERB
gs-3960	251	9	in	in	ADP
gs-3960	251	10	parkinson	parkinson	NOUN
gs-3960	251	11	's	's	PART
gs-3960	251	12	pathology	pathology	NOUN
gs-3960	251	13	,	,	PUNCT
gs-3960	251	14	appears	appear	VERB
gs-3960	251	15	to	to	PART
gs-3960	251	16	play	play	VERB
gs-3960	251	17	a	a	DET
gs-3960	251	18	surprising	surprising	ADJ
gs-3960	251	19	role	role	NOUN
gs-3960	251	20	in	in	ADP
gs-3960	251	21	regulating	regulate	VERB
gs-3960	251	22	mam	mam	NOUN
gs-3960	251	23	function	function	NOUN
gs-3960	251	24	.	.	PUNCT
gs-3960	252	1	oligomeric	oligomeric	ADJ
gs-3960	252	2	forms	form	NOUN
gs-3960	252	3	of	of	ADP
gs-3960	252	4	alpha	alpha	NOUN
gs-3960	252	5	-	-	PUNCT
gs-3960	252	6	synuclein	synuclein	NOUN
gs-3960	252	7	localize	localize	NOUN
gs-3960	252	8	to	to	ADP
gs-3960	252	9	these	these	DET
gs-3960	252	10	contact	contact	NOUN
gs-3960	252	11	sites	site	NOUN
gs-3960	252	12	,	,	PUNCT
gs-3960	252	13	interfering	interfere	VERB
gs-3960	252	14	with	with	ADP
gs-3960	252	15	the	the	DET
gs-3960	252	16	vapb	vapb	NOUN
gs-3960	252	17	-	-	PUNCT
gs-3960	252	18	ptpip51	ptpip51	ADJ
gs-3960	252	19	tethering	tether	VERB
gs-3960	252	20	complex	complex	NOUN
gs-3960	252	21	and	and	CCONJ
gs-3960	252	22	disrupting	disrupt	VERB
gs-3960	252	23	calcium	calcium	NOUN
gs-3960	252	24	homeostasis	homeostasis	NOUN
gs-3960	252	25	.	.	PUNCT
gs-3960	253	1	this	this	DET
gs-3960	253	2	discovery	discovery	NOUN
gs-3960	253	3	provides	provide	VERB
gs-3960	253	4	a	a	DET
gs-3960	253	5	mechanistic	mechanistic	ADJ
gs-3960	253	6	link	link	NOUN
gs-3960	253	7	between	between	ADP
gs-3960	253	8	protein	protein	NOUN
gs-3960	253	9	aggregation	aggregation	NOUN
gs-3960	253	10	and	and	CCONJ
gs-3960	253	11	mitochondrial	mitochondrial	ADJ
gs-3960	253	12	dysfunction	dysfunction	NOUN
gs-3960	253	13	that	that	PRON
gs-3960	253	14	was	be	AUX
gs-3960	253	15	previously	previously	ADV
gs-3960	253	16	unrecognized	unrecognize	VERB
gs-3960	253	17	.	.	PUNCT
gs-3960	254	1	intriguingly	intriguingly	ADV
gs-3960	254	2	,	,	PUNCT
gs-3960	254	3	certain	certain	ADJ
gs-3960	254	4	genetic	genetic	ADJ
gs-3960	254	5	variants	variant	NOUN
gs-3960	254	6	of	of	ADP
gs-3960	254	7	alpha	alpha	NOUN
gs-3960	254	8	-	-	PUNCT
gs-3960	254	9	synuclein	synuclein	NOUN
gs-3960	254	10	associated	associate	VERB
gs-3960	254	11	with	with	ADP
gs-3960	254	12	higher	high	ADJ
gs-3960	254	13	parkinson	parkinson	NOUN
gs-3960	254	14	's	's	PART
gs-3960	254	15	risk	risk	NOUN
gs-3960	254	16	show	show	VERB
gs-3960	254	17	greater	great	ADJ
gs-3960	254	18	affinity	affinity	NOUN
gs-3960	254	19	for	for	ADP
gs-3960	254	20	mams	mam	NOUN
gs-3960	254	21	,	,	PUNCT
gs-3960	254	22	suggesting	suggest	VERB
gs-3960	254	23	this	this	PRON
gs-3960	254	24	may	may	AUX
gs-3960	254	25	be	be	AUX
gs-3960	254	26	a	a	DET
gs-3960	254	27	key	key	ADJ
gs-3960	254	28	determinant	determinant	NOUN
gs-3960	254	29	of	of	ADP
gs-3960	254	30	their	their	PRON
gs-3960	254	31	pathogenicity	pathogenicity	NOUN
gs-3960	255	1	[	[	X
gs-3960	255	2	76,79,82	76,79,82	NUM
gs-3960	255	3	]	]	X
gs-3960	255	4	.	.	PUNCT
gs-3960	256	1	circadian	circadian	ADJ
gs-3960	256	2	regulation	regulation	NOUN
gs-3960	256	3	of	of	ADP
gs-3960	256	4	mitochondrial	mitochondrial	ADJ
gs-3960	256	5	function	function	NOUN
gs-3960	256	6	another	another	DET
gs-3960	256	7	paradigm	paradigm	NOUN
gs-3960	256	8	-	-	PUNCT
gs-3960	256	9	shifting	shift	VERB
gs-3960	256	10	development	development	NOUN
gs-3960	256	11	comes	come	VERB
gs-3960	256	12	from	from	ADP
gs-3960	256	13	studies	study	NOUN
gs-3960	256	14	of	of	ADP
gs-3960	256	15	circadian	circadian	ADJ
gs-3960	256	16	biology	biology	NOUN
gs-3960	256	17	in	in	ADP
gs-3960	256	18	parkinson	parkinson	NOUN
gs-3960	256	19	's	's	PART
gs-3960	256	20	disease	disease	NOUN
gs-3960	256	21	.	.	PUNCT
gs-3960	257	1	mitochondrial	mitochondrial	ADJ
gs-3960	257	2	function	function	NOUN
gs-3960	257	3	in	in	ADP
gs-3960	257	4	dopaminergic	dopaminergic	ADJ
gs-3960	257	5	neurons	neuron	NOUN
gs-3960	257	6	exhibits	exhibit	VERB
gs-3960	257	7	robust	robust	ADJ
gs-3960	257	8	circadian	circadian	ADJ
gs-3960	257	9	oscillations	oscillation	NOUN
gs-3960	257	10	,	,	PUNCT
gs-3960	257	11	with	with	ADP
gs-3960	257	12	peak	peak	ADJ
gs-3960	257	13	respiratory	respiratory	ADJ
gs-3960	257	14	capacity	capacity	NOUN
gs-3960	257	15	occurring	occur	VERB
gs-3960	257	16	during	during	ADP
gs-3960	257	17	the	the	DET
gs-3960	257	18	active	active	ADJ
gs-3960	257	19	phase	phase	NOUN
gs-3960	257	20	.	.	PUNCT
gs-3960	258	1	this	this	DET
gs-3960	258	2	rhythmicity	rhythmicity	NOUN
gs-3960	258	3	is	be	AUX
gs-3960	258	4	maintained	maintain	VERB
gs-3960	258	5	by	by	ADP
gs-3960	258	6	clock	clock	NOUN
gs-3960	258	7	-	-	PUNCT
gs-3960	258	8	controlled	control	VERB
gs-3960	258	9	genes	gene	NOUN
gs-3960	258	10	that	that	PRON
gs-3960	258	11	regulate	regulate	VERB
gs-3960	258	12	mitochondrial	mitochondrial	ADJ
gs-3960	258	13	biogenesis	biogenesis	NOUN
gs-3960	258	14	,	,	PUNCT
gs-3960	258	15	dynamics	dynamic	NOUN
gs-3960	258	16	,	,	PUNCT
gs-3960	258	17	and	and	CCONJ
gs-3960	258	18	quality	quality	NOUN
gs-3960	258	19	control	control	NOUN
gs-3960	258	20	.	.	PUNCT
gs-3960	259	1	strikingly	strikingly	ADV
gs-3960	259	2	,	,	PUNCT
gs-3960	259	3	parkinson	parkinson	NOUN
gs-3960	259	4	's	's	PART
gs-3960	259	5	patients	patient	NOUN
gs-3960	259	6	show	show	VERB
gs-3960	259	7	marked	mark	VERB
gs-3960	259	8	disruption	disruption	NOUN
gs-3960	259	9	of	of	ADP
gs-3960	259	10	these	these	DET
gs-3960	259	11	circadian	circadian	ADJ
gs-3960	259	12	mitochondrial	mitochondrial	ADJ
gs-3960	259	13	patterns	pattern	NOUN
gs-3960	259	14	,	,	PUNCT
gs-3960	259	15	with	with	ADP
gs-3960	259	16	post	post	ADJ
gs-3960	259	17	-	-	ADJ
gs-3960	259	18	mortem	mortem	ADJ
gs-3960	259	19	studies	study	NOUN
gs-3960	259	20	revealing	reveal	VERB
gs-3960	259	21	loss	loss	NOUN
gs-3960	259	22	of	of	ADP
gs-3960	259	23	normal	normal	ADJ
gs-3960	259	24	oscillation	oscillation	NOUN
gs-3960	259	25	in	in	ADP
gs-3960	259	26	electron	electron	NOUN
gs-3960	259	27	transport	transport	NOUN
gs-3960	259	28	chain	chain	NOUN
gs-3960	259	29	activity	activity	NOUN
gs-3960	259	30	.	.	PUNCT
gs-3960	260	1	the	the	DET
gs-3960	260	2	implications	implication	NOUN
gs-3960	260	3	of	of	ADP
gs-3960	260	4	this	this	DET
gs-3960	260	5	discovery	discovery	NOUN
gs-3960	260	6	are	be	AUX
gs-3960	260	7	profound	profound	ADJ
gs-3960	260	8	.	.	PUNCT
gs-3960	261	1	animal	animal	NOUN
gs-3960	261	2	models	model	NOUN
gs-3960	261	3	with	with	ADP
gs-3960	261	4	targeted	target	VERB
gs-3960	261	5	disruption	disruption	NOUN
gs-3960	261	6	of	of	ADP
gs-3960	261	7	circadian	circadian	ADJ
gs-3960	261	8	clock	clock	NOUN
gs-3960	261	9	genes	gene	NOUN
gs-3960	261	10	in	in	ADP
gs-3960	261	11	dopaminergic	dopaminergic	ADJ
gs-3960	261	12	neurons	neuron	NOUN
gs-3960	261	13	develop	develop	VERB
gs-3960	261	14	progressive	progressive	ADJ
gs-3960	261	15	parkinsonian	parkinsonian	ADJ
gs-3960	261	16	features	feature	NOUN
gs-3960	261	17	,	,	PUNCT
gs-3960	261	18	including	include	VERB
gs-3960	261	19	motor	motor	NOUN
gs-3960	261	20	deficits	deficit	NOUN
gs-3960	261	21	and	and	CCONJ
gs-3960	261	22	selective	selective	ADJ
gs-3960	261	23	neuronal	neuronal	ADJ
gs-3960	261	24	loss	loss	NOUN
gs-3960	261	25	.	.	PUNCT
gs-3960	262	1	conversely	conversely	ADV
gs-3960	262	2	,	,	PUNCT
gs-3960	262	3	time	time	NOUN
gs-3960	262	4	-	-	PUNCT
gs-3960	262	5	restricted	restrict	VERB
gs-3960	262	6	feeding	feeding	NOUN
gs-3960	262	7	can	can	AUX
gs-3960	262	8	rescue	rescue	VERB
gs-3960	262	9	mitochondrial	mitochondrial	ADJ
gs-3960	262	10	dysfunction	dysfunction	NOUN
gs-3960	262	11	in	in	ADP
gs-3960	262	12	genetic	genetic	ADJ
gs-3960	262	13	parkinson	parkinson	NOUN
gs-3960	262	14	's	's	PART
gs-3960	262	15	models	model	NOUN
gs-3960	262	16	,	,	PUNCT
gs-3960	262	17	even	even	ADV
gs-3960	262	18	without	without	ADP
gs-3960	262	19	altering	alter	VERB
gs-3960	262	20	total	total	ADJ
gs-3960	262	21	caloric	caloric	PROPN
gs-3960	262	22	intake	intake	NOUN
gs-3960	262	23	.	.	PUNCT
gs-3960	263	1	these	these	DET
gs-3960	263	2	findings	finding	NOUN
gs-3960	263	3	suggest	suggest	VERB
gs-3960	263	4	that	that	SCONJ
gs-3960	263	5	chronotherapeutic	chronotherapeutic	ADJ
gs-3960	263	6	approaches	approach	NOUN
gs-3960	263	7	targeting	target	VERB
gs-3960	263	8	mitochondrial	mitochondrial	ADJ
gs-3960	263	9	rhythms	rhythm	NOUN
gs-3960	263	10	may	may	AUX
gs-3960	263	11	represent	represent	VERB
gs-3960	263	12	a	a	DET
gs-3960	263	13	novel	novel	ADJ
gs-3960	263	14	intervention	intervention	NOUN
gs-3960	263	15	strategy	strategy	NOUN
gs-3960	263	16	.	.	PUNCT
gs-3960	264	1	sex	sex	NOUN
gs-3960	264	2	-	-	PUNCT
gs-3960	264	3	specific	specific	ADJ
gs-3960	264	4	mitochondrial	mitochondrial	ADJ
gs-3960	264	5	adaptations	adaptation	NOUN
gs-3960	264	6	recent	recent	ADJ
gs-3960	264	7	work	work	NOUN
gs-3960	264	8	has	have	AUX
gs-3960	264	9	uncovered	uncover	VERB
gs-3960	264	10	significant	significant	ADJ
gs-3960	264	11	sex	sex	NOUN
gs-3960	264	12	differences	difference	NOUN
gs-3960	264	13	in	in	ADP
gs-3960	264	14	how	how	SCONJ
gs-3960	264	15	dopaminergic	dopaminergic	ADJ
gs-3960	264	16	neurons	neuron	NOUN
gs-3960	264	17	maintain	maintain	VERB
gs-3960	264	18	mitochondrial	mitochondrial	ADJ
gs-3960	264	19	homeostasis	homeostasis	NOUN
gs-3960	264	20	.	.	PUNCT
gs-3960	265	1	female	female	ADJ
gs-3960	265	2	neurons	neuron	NOUN
gs-3960	265	3	appear	appear	VERB
gs-3960	265	4	to	to	PART
gs-3960	265	5	have	have	AUX
gs-3960	265	6	enhanced	enhance	VERB
gs-3960	265	7	mitochondrial	mitochondrial	ADJ
gs-3960	265	8	spare	spare	ADJ
gs-3960	265	9	respiratory	respiratory	ADJ
gs-3960	265	10	capacity	capacity	NOUN
gs-3960	265	11	and	and	CCONJ
gs-3960	265	12	more	more	ADV
gs-3960	265	13	robust	robust	ADJ
gs-3960	265	14	antioxidant	antioxidant	ADJ
gs-3960	265	15	defenses	defense	NOUN
gs-3960	265	16	under	under	ADP
gs-3960	265	17	basal	basal	ADJ
gs-3960	265	18	georgian	georgian	NOUN
gs-3960	265	19	scientists/	scientists/	NUM
gs-3960	265	20	.	.	PUNCT
gs-3960	266	1	7	7	NUM
gs-3960	266	2	n	n	PRON
gs-3960	266	3	3	3	NUM
gs-3960	266	4	,	,	PUNCT
gs-3960	266	5	2025	2025	NUM
gs-3960	266	6	414	414	NUM
gs-3960	266	7	conditions	condition	NOUN
gs-3960	266	8	.	.	PUNCT
gs-3960	267	1	this	this	DET
gs-3960	267	2	difference	difference	NOUN
gs-3960	267	3	is	be	AUX
gs-3960	267	4	mediated	mediate	VERB
gs-3960	267	5	in	in	ADP
gs-3960	267	6	part	part	NOUN
gs-3960	267	7	by	by	ADP
gs-3960	267	8	estrogen	estrogen	NOUN
gs-3960	267	9	receptor	receptor	NOUN
gs-3960	267	10	signaling	signal	VERB
gs-3960	267	11	in	in	ADP
gs-3960	267	12	astrocytes	astrocyte	NOUN
gs-3960	267	13	,	,	PUNCT
gs-3960	267	14	which	which	PRON
gs-3960	267	15	modulates	modulate	VERB
gs-3960	267	16	the	the	DET
gs-3960	267	17	availability	availability	NOUN
gs-3960	267	18	of	of	ADP
gs-3960	267	19	mitochondrial	mitochondrial	ADJ
gs-3960	267	20	substrates	substrate	NOUN
gs-3960	267	21	to	to	ADP
gs-3960	267	22	neighboring	neighboring	NOUN
gs-3960	267	23	neurons	neuron	NOUN
gs-3960	267	24	.	.	PUNCT
gs-3960	268	1	the	the	DET
gs-3960	268	2	clinical	clinical	ADJ
gs-3960	268	3	correlation	correlation	NOUN
gs-3960	268	4	is	be	AUX
gs-3960	268	5	striking	strike	VERB
gs-3960	268	6	epidemiological	epidemiological	ADJ
gs-3960	268	7	studies	study	NOUN
gs-3960	268	8	show	show	VERB
gs-3960	268	9	that	that	SCONJ
gs-3960	268	10	women	woman	NOUN
gs-3960	268	11	have	have	VERB
gs-3960	268	12	a	a	DET
gs-3960	268	13	lower	low	ADJ
gs-3960	268	14	incidence	incidence	NOUN
gs-3960	268	15	of	of	ADP
gs-3960	268	16	parkinson	parkinson	NOUN
gs-3960	268	17	's	's	PART
gs-3960	268	18	disease	disease	NOUN
gs-3960	268	19	until	until	ADP
gs-3960	268	20	menopause	menopause	NOUN
gs-3960	268	21	,	,	PUNCT
gs-3960	268	22	after	after	ADP
gs-3960	268	23	which	which	PRON
gs-3960	268	24	their	their	PRON
gs-3960	268	25	risk	risk	NOUN
gs-3960	268	26	converges	converge	VERB
gs-3960	268	27	with	with	ADP
gs-3960	268	28	men	man	NOUN
gs-3960	268	29	.	.	PUNCT
gs-3960	269	1	at	at	ADP
gs-3960	269	2	the	the	DET
gs-3960	269	3	molecular	molecular	ADJ
gs-3960	269	4	level	level	NOUN
gs-3960	269	5	,	,	PUNCT
gs-3960	269	6	female	female	ADJ
gs-3960	269	7	dopaminergic	dopaminergic	ADJ
gs-3960	269	8	neurons	neuron	NOUN
gs-3960	269	9	maintain	maintain	VERB
gs-3960	269	10	higher	high	ADJ
gs-3960	269	11	levels	level	NOUN
gs-3960	269	12	of	of	ADP
gs-3960	269	13	the	the	DET
gs-3960	269	14	mitochondrial	mitochondrial	ADJ
gs-3960	269	15	deacetylase	deacetylase	NOUN
gs-3960	269	16	sirt3	sirt3	PROPN
gs-3960	269	17	,	,	PUNCT
gs-3960	269	18	which	which	PRON
gs-3960	269	19	preserves	preserve	VERB
gs-3960	269	20	complex	complex	ADJ
gs-3960	269	21	i	i	PRON
gs-3960	269	22	function	function	VERB
gs-3960	269	23	and	and	CCONJ
gs-3960	269	24	reduces	reduce	VERB
gs-3960	269	25	oxidative	oxidative	ADJ
gs-3960	269	26	damage	damage	NOUN
gs-3960	269	27	.	.	PUNCT
gs-3960	270	1	this	this	DET
gs-3960	270	2	natural	natural	ADJ
gs-3960	270	3	protection	protection	NOUN
gs-3960	270	4	may	may	AUX
gs-3960	270	5	explain	explain	VERB
gs-3960	270	6	why	why	SCONJ
gs-3960	270	7	many	many	ADJ
gs-3960	270	8	neuroprotective	neuroprotective	ADJ
gs-3960	270	9	compounds	compound	NOUN
gs-3960	270	10	show	show	VERB
gs-3960	270	11	greater	great	ADJ
gs-3960	270	12	efficacy	efficacy	NOUN
gs-3960	270	13	in	in	ADP
gs-3960	270	14	male	male	ADJ
gs-3960	270	15	animal	animal	NOUN
gs-3960	270	16	models	model	NOUN
gs-3960	270	17	of	of	ADP
gs-3960	270	18	parkinson	parkinson	NOUN
gs-3960	270	19	's	's	PART
gs-3960	270	20	disease	disease	NOUN
gs-3960	270	21	.	.	PUNCT
gs-3960	271	1	the	the	DET
gs-3960	271	2	therapeutic	therapeutic	ADJ
gs-3960	271	3	implication	implication	NOUN
gs-3960	271	4	is	be	AUX
gs-3960	271	5	that	that	SCONJ
gs-3960	271	6	sex	sex	NOUN
gs-3960	271	7	-	-	PUNCT
gs-3960	271	8	specific	specific	ADJ
gs-3960	271	9	mitochondrial	mitochondrial	ADJ
gs-3960	271	10	support	support	NOUN
gs-3960	271	11	strategies	strategy	NOUN
gs-3960	271	12	may	may	AUX
gs-3960	271	13	be	be	AUX
gs-3960	271	14	needed	need	VERB
gs-3960	271	15	,	,	PUNCT
gs-3960	271	16	with	with	ADP
gs-3960	271	17	premenopausal	premenopausal	NOUN
gs-3960	271	18	women	woman	NOUN
gs-3960	271	19	potentially	potentially	ADV
gs-3960	271	20	requiring	require	VERB
gs-3960	271	21	different	different	ADJ
gs-3960	271	22	interventions	intervention	NOUN
gs-3960	271	23	than	than	ADP
gs-3960	271	24	men	man	NOUN
gs-3960	271	25	or	or	CCONJ
gs-3960	271	26	postmenopausal	postmenopausal	ADJ
gs-3960	271	27	women	woman	NOUN
gs-3960	271	28	.	.	PUNCT
gs-3960	272	1	the	the	DET
gs-3960	272	2	gut	gut	NOUN
gs-3960	272	3	-	-	PUNCT
gs-3960	272	4	mitochondria	mitochondria	NOUN
gs-3960	272	5	axis	axis	NOUN
gs-3960	272	6	in	in	ADP
gs-3960	272	7	parkinson	parkinson	NOUN
gs-3960	272	8	's	's	PART
gs-3960	272	9	pathogenesis	pathogenesis	NOUN
gs-3960	272	10	the	the	DET
gs-3960	272	11	growing	grow	VERB
gs-3960	272	12	recognition	recognition	NOUN
gs-3960	272	13	of	of	ADP
gs-3960	272	14	gut	gut	NOUN
gs-3960	272	15	-	-	PUNCT
gs-3960	272	16	brain	brain	NOUN
gs-3960	272	17	interactions	interaction	NOUN
gs-3960	272	18	in	in	ADP
gs-3960	272	19	parkinson	parkinson	NOUN
gs-3960	272	20	's	's	PART
gs-3960	272	21	disease	disease	NOUN
gs-3960	272	22	has	have	AUX
gs-3960	272	23	led	lead	VERB
gs-3960	272	24	to	to	ADP
gs-3960	272	25	the	the	DET
gs-3960	272	26	discovery	discovery	NOUN
gs-3960	272	27	of	of	ADP
gs-3960	272	28	a	a	DET
gs-3960	272	29	novel	novel	NOUN
gs-3960	272	30	"	"	PUNCT
gs-3960	272	31	gut	gut	NOUN
gs-3960	272	32	-	-	PUNCT
gs-3960	272	33	mitochondria	mitochondria	NOUN
gs-3960	272	34	axis	axis	NOUN
gs-3960	272	35	.	.	PUNCT
gs-3960	272	36	"	"	PUNCT
gs-3960	273	1	certain	certain	ADJ
gs-3960	273	2	gut	gut	NOUN
gs-3960	273	3	microbiota	microbiota	NOUN
gs-3960	273	4	metabolites	metabolite	NOUN
gs-3960	273	5	,	,	PUNCT
gs-3960	273	6	particularly	particularly	ADV
gs-3960	273	7	short	short	ADJ
gs-3960	273	8	-	-	PUNCT
gs-3960	273	9	chain	chain	NOUN
gs-3960	273	10	fatty	fatty	NOUN
gs-3960	273	11	acids	acid	NOUN
gs-3960	273	12	and	and	CCONJ
gs-3960	273	13	secondary	secondary	ADJ
gs-3960	273	14	bile	bile	NOUN
gs-3960	273	15	acids	acid	NOUN
gs-3960	273	16	,	,	PUNCT
gs-3960	273	17	can	can	AUX
gs-3960	273	18	directly	directly	ADV
gs-3960	273	19	modulate	modulate	VERB
gs-3960	273	20	mitochondrial	mitochondrial	ADJ
gs-3960	273	21	function	function	NOUN
gs-3960	273	22	in	in	ADP
gs-3960	273	23	dopaminergic	dopaminergic	ADJ
gs-3960	273	24	neurons	neuron	NOUN
gs-3960	273	25	.	.	PUNCT
gs-3960	274	1	for	for	ADP
gs-3960	274	2	example	example	NOUN
gs-3960	274	3	,	,	PUNCT
gs-3960	274	4	butyrate	butyrate	NOUN
gs-3960	274	5	enhances	enhance	VERB
gs-3960	274	6	mitochondrial	mitochondrial	ADJ
gs-3960	274	7	biogenesis	biogenesis	NOUN
gs-3960	274	8	through	through	ADP
gs-3960	274	9	hdac	hdac	NOUN
gs-3960	274	10	inhibition	inhibition	NOUN
gs-3960	274	11	,	,	PUNCT
gs-3960	274	12	while	while	SCONJ
gs-3960	274	13	specific	specific	ADJ
gs-3960	274	14	bile	bile	NOUN
gs-3960	274	15	acid	acid	NOUN
gs-3960	274	16	metabolites	metabolite	NOUN
gs-3960	274	17	act	act	VERB
gs-3960	274	18	as	as	SCONJ
gs-3960	274	19	potent	potent	ADJ
gs-3960	274	20	inhibitors	inhibitor	NOUN
gs-3960	274	21	of	of	ADP
gs-3960	274	22	the	the	DET
gs-3960	274	23	mitochondrial	mitochondrial	ADJ
gs-3960	274	24	permeability	permeability	NOUN
gs-3960	274	25	transition	transition	NOUN
gs-3960	274	26	pore	pore	NOUN
gs-3960	274	27	.	.	PUNCT
gs-3960	275	1	fascinatingly	fascinatingly	ADV
gs-3960	275	2	,	,	PUNCT
gs-3960	275	3	parkinson	parkinson	NOUN
gs-3960	275	4	's	's	PART
gs-3960	275	5	patients	patient	NOUN
gs-3960	275	6	show	show	VERB
gs-3960	275	7	distinct	distinct	ADJ
gs-3960	275	8	alterations	alteration	NOUN
gs-3960	275	9	in	in	ADP
gs-3960	275	10	their	their	PRON
gs-3960	275	11	gut	gut	NOUN
gs-3960	275	12	microbiome	microbiome	NOUN
gs-3960	275	13	that	that	PRON
gs-3960	275	14	correlate	correlate	VERB
gs-3960	275	15	with	with	ADP
gs-3960	275	16	mitochondrial	mitochondrial	ADJ
gs-3960	275	17	functional	functional	ADJ
gs-3960	275	18	markers	marker	NOUN
gs-3960	275	19	in	in	ADP
gs-3960	275	20	peripheral	peripheral	ADJ
gs-3960	275	21	blood	blood	NOUN
gs-3960	275	22	cells	cell	NOUN
gs-3960	275	23	.	.	PUNCT
gs-3960	276	1	fecal	fecal	ADJ
gs-3960	276	2	microbiota	microbiota	NOUN
gs-3960	276	3	transplantation	transplantation	NOUN
gs-3960	276	4	from	from	ADP
gs-3960	276	5	parkinson	parkinson	NOUN
gs-3960	276	6	's	's	PART
gs-3960	276	7	patients	patient	NOUN
gs-3960	276	8	to	to	PART
gs-3960	276	9	germ	germ	NOUN
gs-3960	276	10	-	-	PUNCT
gs-3960	276	11	free	free	ADJ
gs-3960	276	12	mice	mice	NOUN
gs-3960	276	13	reproduces	reproduce	VERB
gs-3960	276	14	key	key	ADJ
gs-3960	276	15	mitochondrial	mitochondrial	ADJ
gs-3960	276	16	abnormalities	abnormality	NOUN
gs-3960	276	17	seen	see	VERB
gs-3960	276	18	in	in	ADP
gs-3960	276	19	the	the	DET
gs-3960	276	20	human	human	ADJ
gs-3960	276	21	disease	disease	NOUN
gs-3960	276	22	.	.	PUNCT
gs-3960	277	1	this	this	PRON
gs-3960	277	2	suggests	suggest	VERB
gs-3960	277	3	that	that	SCONJ
gs-3960	277	4	at	at	ADV
gs-3960	277	5	least	least	ADJ
gs-3960	277	6	some	some	DET
gs-3960	277	7	aspects	aspect	NOUN
gs-3960	277	8	of	of	ADP
gs-3960	277	9	mitochondrial	mitochondrial	ADJ
gs-3960	277	10	dysfunction	dysfunction	NOUN
gs-3960	277	11	may	may	AUX
gs-3960	277	12	originate	originate	VERB
gs-3960	277	13	in	in	ADP
gs-3960	277	14	the	the	DET
gs-3960	277	15	gut	gut	NOUN
gs-3960	277	16	and	and	CCONJ
gs-3960	277	17	spread	spread	VERB
gs-3960	277	18	to	to	ADP
gs-3960	277	19	the	the	DET
gs-3960	277	20	brain	brain	NOUN
gs-3960	277	21	via	via	ADP
gs-3960	277	22	circulating	circulate	VERB
gs-3960	277	23	factors	factor	NOUN
gs-3960	277	24	[	[	X
gs-3960	277	25	29,79,81	29,79,81	NUM
gs-3960	277	26	]	]	PUNCT
gs-3960	277	27	novel	novel	ADJ
gs-3960	277	28	mitochondrial	mitochondrial	ADJ
gs-3960	277	29	quality	quality	NOUN
gs-3960	277	30	control	control	NOUN
gs-3960	277	31	pathways	pathway	NOUN
gs-3960	277	32	beyond	beyond	ADP
gs-3960	277	33	the	the	DET
gs-3960	277	34	canonical	canonical	ADJ
gs-3960	277	35	pink1	pink1	NOUN
gs-3960	277	36	-	-	PUNCT
gs-3960	277	37	parkin	parkin	ADJ
gs-3960	277	38	mitophagy	mitophagy	NOUN
gs-3960	277	39	pathway	pathway	NOUN
gs-3960	277	40	,	,	PUNCT
gs-3960	277	41	researchers	researcher	NOUN
gs-3960	277	42	have	have	AUX
gs-3960	277	43	identified	identify	VERB
gs-3960	277	44	several	several	ADJ
gs-3960	277	45	alternative	alternative	ADJ
gs-3960	277	46	mitochondrial	mitochondrial	ADJ
gs-3960	277	47	quality	quality	NOUN
gs-3960	277	48	control	control	NOUN
gs-3960	277	49	mechanisms	mechanism	NOUN
gs-3960	277	50	that	that	PRON
gs-3960	277	51	are	be	AUX
gs-3960	277	52	particularly	particularly	ADV
gs-3960	277	53	relevant	relevant	ADJ
gs-3960	277	54	to	to	ADP
gs-3960	277	55	parkinson	parkinson	NOUN
gs-3960	277	56	's	's	PART
gs-3960	277	57	disease	disease	NOUN
gs-3960	277	58	.	.	PUNCT
gs-3960	278	1	one	one	NUM
gs-3960	278	2	such	such	ADJ
gs-3960	278	3	pathway	pathway	NOUN
gs-3960	278	4	involves	involve	VERB
gs-3960	278	5	mitochondrialderived	mitochondrialderived	ADJ
gs-3960	278	6	vesicles	vesicle	NOUN
gs-3960	278	7	(	(	PUNCT
gs-3960	278	8	mdvs	mdvs	ADJ
gs-3960	278	9	)	)	PUNCT
gs-3960	278	10	,	,	PUNCT
gs-3960	278	11	which	which	PRON
gs-3960	278	12	bud	bud	VERB
gs-3960	278	13	off	off	ADP
gs-3960	278	14	from	from	ADP
gs-3960	278	15	mitochondria	mitochondria	NOUN
gs-3960	278	16	to	to	PART
gs-3960	278	17	selectively	selectively	ADV
gs-3960	278	18	remove	remove	VERB
gs-3960	278	19	damaged	damaged	ADJ
gs-3960	278	20	components	component	NOUN
gs-3960	278	21	.	.	PUNCT
gs-3960	279	1	these	these	DET
gs-3960	279	2	mdvs	mdvs	ADJ
gs-3960	279	3	are	be	AUX
gs-3960	279	4	enriched	enrich	VERB
gs-3960	279	5	for	for	ADP
gs-3960	279	6	oxidized	oxidized	ADJ
gs-3960	279	7	proteins	protein	NOUN
gs-3960	279	8	and	and	CCONJ
gs-3960	279	9	damaged	damage	VERB
gs-3960	279	10	mitochondrial	mitochondrial	ADJ
gs-3960	279	11	dna	dna	NOUN
gs-3960	279	12	,	,	PUNCT
gs-3960	279	13	providing	provide	VERB
gs-3960	279	14	a	a	DET
gs-3960	279	15	more	more	ADV
gs-3960	279	16	targeted	targeted	ADJ
gs-3960	279	17	alternative	alternative	NOUN
gs-3960	279	18	to	to	ADP
gs-3960	279	19	whole	whole	ADJ
gs-3960	279	20	-	-	PUNCT
gs-3960	279	21	organelle	organelle	NOUN
gs-3960	279	22	degradation	degradation	NOUN
gs-3960	279	23	.	.	PUNCT
gs-3960	280	1	in	in	ADP
gs-3960	280	2	parkinson	parkinson	NOUN
gs-3960	280	3	's	's	PART
gs-3960	280	4	,	,	PUNCT
gs-3960	280	5	this	this	DET
gs-3960	280	6	mdv	mdv	NOUN
gs-3960	280	7	pathway	pathway	NOUN
gs-3960	280	8	appears	appear	VERB
gs-3960	280	9	to	to	PART
gs-3960	280	10	be	be	AUX
gs-3960	280	11	hyperactivated	hyperactivate	VERB
gs-3960	280	12	as	as	ADP
gs-3960	280	13	a	a	DET
gs-3960	280	14	compensatory	compensatory	ADJ
gs-3960	280	15	mechanism	mechanism	NOUN
gs-3960	280	16	when	when	SCONJ
gs-3960	280	17	mitophagy	mitophagy	NOUN
gs-3960	280	18	is	be	AUX
gs-3960	280	19	impaired	impaired	ADJ
gs-3960	280	20	.	.	PUNCT
gs-3960	281	1	however	however	ADV
gs-3960	281	2	,	,	PUNCT
gs-3960	281	3	the	the	DET
gs-3960	281	4	sustained	sustained	ADJ
gs-3960	281	5	production	production	NOUN
gs-3960	281	6	of	of	ADP
gs-3960	281	7	mdvs	mdvs	ADJ
gs-3960	281	8	may	may	AUX
gs-3960	281	9	have	have	VERB
gs-3960	281	10	unintended	unintended	ADJ
gs-3960	281	11	consequences	consequence	NOUN
gs-3960	281	12	,	,	PUNCT
gs-3960	281	13	as	as	SCONJ
gs-3960	281	14	these	these	DET
gs-3960	281	15	vesicles	vesicle	NOUN
gs-3960	281	16	can	can	AUX
gs-3960	281	17	trigger	trigger	VERB
gs-3960	281	18	neuroinflammation	neuroinflammation	NOUN
gs-3960	281	19	when	when	SCONJ
gs-3960	281	20	their	their	PRON
gs-3960	281	21	contents	content	NOUN
gs-3960	281	22	are	be	AUX
gs-3960	281	23	detected	detect	VERB
gs-3960	281	24	by	by	ADP
gs-3960	281	25	cytoplasmic	cytoplasmic	ADJ
gs-3960	281	26	sensors	sensor	NOUN
gs-3960	281	27	.	.	PUNCT
gs-3960	282	1	this	this	PRON
gs-3960	282	2	may	may	AUX
gs-3960	282	3	explain	explain	VERB
gs-3960	282	4	the	the	DET
gs-3960	282	5	paradoxical	paradoxical	ADJ
gs-3960	282	6	observation	observation	NOUN
gs-3960	282	7	that	that	SCONJ
gs-3960	282	8	some	some	DET
gs-3960	282	9	parkinson	parkinson	NOUN
gs-3960	282	10	's	's	PART
gs-3960	282	11	patients	patient	NOUN
gs-3960	282	12	show	show	VERB
gs-3960	282	13	both	both	DET
gs-3960	282	14	impaired	impaired	ADJ
gs-3960	282	15	mitophagy	mitophagy	NOUN
gs-3960	282	16	and	and	CCONJ
gs-3960	282	17	elevated	elevated	ADJ
gs-3960	282	18	inflammatory	inflammatory	ADJ
gs-3960	282	19	markers	marker	NOUN
gs-3960	282	20	simultaneously	simultaneously	ADV
gs-3960	282	21	.	.	PUNCT
gs-3960	283	1	georgian	georgian	NOUN
gs-3960	283	2	scientists/	scientists/	NUM
gs-3960	283	3	.	.	PUNCT
gs-3960	284	1	7	7	NUM
gs-3960	284	2	n	n	PRON
gs-3960	284	3	3	3	NUM
gs-3960	284	4	,	,	PUNCT
gs-3960	284	5	2025	2025	NUM
gs-3960	284	6	415	415	NUM
gs-3960	284	7	metabolic	metabolic	NOUN
gs-3960	284	8	flexibility	flexibility	NOUN
gs-3960	284	9	and	and	CCONJ
gs-3960	284	10	neuronal	neuronal	ADJ
gs-3960	284	11	survival	survival	NOUN
gs-3960	284	12	dopaminergic	dopaminergic	ADJ
gs-3960	284	13	neurons	neuron	NOUN
gs-3960	284	14	exhibit	exhibit	VERB
gs-3960	284	15	remarkable	remarkable	ADJ
gs-3960	284	16	metabolic	metabolic	NOUN
gs-3960	284	17	flexibility	flexibility	NOUN
gs-3960	284	18	under	under	ADP
gs-3960	284	19	normal	normal	ADJ
gs-3960	284	20	conditions	condition	NOUN
gs-3960	284	21	,	,	PUNCT
gs-3960	284	22	able	able	ADJ
gs-3960	284	23	to	to	PART
gs-3960	284	24	shift	shift	VERB
gs-3960	284	25	between	between	ADP
gs-3960	284	26	glycolysis	glycolysis	NOUN
gs-3960	284	27	and	and	CCONJ
gs-3960	284	28	oxidative	oxidative	ADJ
gs-3960	284	29	phosphorylation	phosphorylation	NOUN
gs-3960	284	30	depending	depend	VERB
gs-3960	284	31	on	on	ADP
gs-3960	284	32	energy	energy	NOUN
gs-3960	284	33	demands	demand	NOUN
gs-3960	284	34	and	and	CCONJ
gs-3960	284	35	substrate	substrate	NOUN
gs-3960	284	36	availability	availability	NOUN
gs-3960	284	37	.	.	PUNCT
gs-3960	285	1	new	new	ADJ
gs-3960	285	2	evidence	evidence	NOUN
gs-3960	285	3	suggests	suggest	VERB
gs-3960	285	4	that	that	SCONJ
gs-3960	285	5	this	this	DET
gs-3960	285	6	flexibility	flexibility	NOUN
gs-3960	285	7	is	be	AUX
gs-3960	285	8	lost	lose	VERB
gs-3960	285	9	in	in	ADP
gs-3960	285	10	parkinson	parkinson	NOUN
gs-3960	285	11	's	's	PART
gs-3960	285	12	disease	disease	NOUN
gs-3960	285	13	,	,	PUNCT
gs-3960	285	14	with	with	ADP
gs-3960	285	15	neurons	neuron	NOUN
gs-3960	285	16	becoming	becoming	AUX
gs-3960	285	17	"	"	PUNCT
gs-3960	285	18	metabolically	metabolically	ADV
gs-3960	285	19	locked	lock	VERB
gs-3960	285	20	"	"	PUNCT
gs-3960	285	21	into	into	ADP
gs-3960	285	22	dysfunctional	dysfunctional	ADJ
gs-3960	285	23	states	state	NOUN
gs-3960	285	24	.	.	PUNCT
gs-3960	286	1	single	single	ADJ
gs-3960	286	2	-	-	PUNCT
gs-3960	286	3	cell	cell	NOUN
gs-3960	286	4	metabolic	metabolic	NOUN
gs-3960	286	5	profiling	profiling	NOUN
gs-3960	286	6	reveals	reveal	VERB
gs-3960	286	7	distinct	distinct	ADJ
gs-3960	286	8	subpopulations	subpopulation	NOUN
gs-3960	286	9	of	of	ADP
gs-3960	286	10	neurons	neuron	NOUN
gs-3960	286	11	that	that	PRON
gs-3960	286	12	differ	differ	VERB
gs-3960	286	13	in	in	ADP
gs-3960	286	14	their	their	PRON
gs-3960	286	15	ability	ability	NOUN
gs-3960	286	16	to	to	PART
gs-3960	286	17	adapt	adapt	VERB
gs-3960	286	18	to	to	ADP
gs-3960	286	19	metabolic	metabolic	NOUN
gs-3960	286	20	stress	stress	NOUN
gs-3960	286	21	,	,	PUNCT
gs-3960	286	22	potentially	potentially	ADV
gs-3960	286	23	explaining	explain	VERB
gs-3960	286	24	selective	selective	ADJ
gs-3960	286	25	vulnerability	vulnerability	NOUN
gs-3960	286	26	patterns	pattern	NOUN
gs-3960	286	27	.	.	PUNCT
gs-3960	287	1	therapeutic	therapeutic	ADJ
gs-3960	287	2	strategies	strategy	NOUN
gs-3960	287	3	aimed	aim	VERB
gs-3960	287	4	at	at	ADP
gs-3960	287	5	restoring	restore	VERB
gs-3960	287	6	metabolic	metabolic	NOUN
gs-3960	287	7	flexibility	flexibility	NOUN
gs-3960	287	8	show	show	NOUN
gs-3960	287	9	promise	promise	NOUN
gs-3960	287	10	in	in	ADP
gs-3960	287	11	preclinical	preclinical	ADJ
gs-3960	287	12	models	model	NOUN
gs-3960	287	13	.	.	PUNCT
gs-3960	288	1	compounds	compound	NOUN
gs-3960	288	2	that	that	PRON
gs-3960	288	3	activate	activate	VERB
gs-3960	288	4	ampk	ampk	NOUN
gs-3960	288	5	or	or	CCONJ
gs-3960	288	6	inhibit	inhibit	VERB
gs-3960	288	7	mtor	mtor	NOUN
gs-3960	288	8	can	can	AUX
gs-3960	288	9	help	help	VERB
gs-3960	288	10	neurons	neuron	NOUN
gs-3960	288	11	regain	regain	VERB
gs-3960	288	12	their	their	PRON
gs-3960	288	13	ability	ability	NOUN
gs-3960	288	14	to	to	PART
gs-3960	288	15	switch	switch	VERB
gs-3960	288	16	between	between	ADP
gs-3960	288	17	energy	energy	NOUN
gs-3960	288	18	production	production	NOUN
gs-3960	288	19	pathways	pathway	NOUN
gs-3960	288	20	,	,	PUNCT
gs-3960	288	21	improving	improve	VERB
gs-3960	288	22	survival	survival	NOUN
gs-3960	288	23	under	under	ADP
gs-3960	288	24	stress	stress	NOUN
gs-3960	288	25	conditions	condition	NOUN
gs-3960	288	26	.	.	PUNCT
gs-3960	289	1	interestingly	interestingly	ADV
gs-3960	289	2	,	,	PUNCT
gs-3960	289	3	certain	certain	ADJ
gs-3960	289	4	dietary	dietary	ADJ
gs-3960	289	5	approaches	approach	NOUN
gs-3960	289	6	like	like	ADP
gs-3960	289	7	intermittent	intermittent	ADJ
gs-3960	289	8	fasting	fasting	NOUN
gs-3960	289	9	appear	appear	VERB
gs-3960	289	10	to	to	PART
gs-3960	289	11	work	work	VERB
gs-3960	289	12	through	through	ADP
gs-3960	289	13	similar	similar	ADJ
gs-3960	289	14	mechanisms	mechanism	NOUN
gs-3960	289	15	,	,	PUNCT
gs-3960	289	16	enhancing	enhance	VERB
gs-3960	289	17	the	the	DET
gs-3960	289	18	neurons	neuron	NOUN
gs-3960	289	19	'	'	PART
gs-3960	289	20	ability	ability	NOUN
gs-3960	289	21	to	to	PART
gs-3960	289	22	utilize	utilize	VERB
gs-3960	289	23	alternative	alternative	ADJ
gs-3960	289	24	fuels	fuel	NOUN
gs-3960	289	25	when	when	SCONJ
gs-3960	289	26	glucose	glucose	NOUN
gs-3960	289	27	metabolism	metabolism	NOUN
gs-3960	289	28	is	be	AUX
gs-3960	289	29	impaired	impaired	ADJ
gs-3960	289	30	.	.	PUNCT
gs-3960	290	1	mitochondrial	mitochondrial	ADJ
gs-3960	290	2	rna	rna	NOUN
gs-3960	290	3	dysregulation	dysregulation	NOUN
gs-3960	290	4	while	while	SCONJ
gs-3960	290	5	much	much	ADJ
gs-3960	290	6	attention	attention	NOUN
gs-3960	290	7	has	have	AUX
gs-3960	290	8	focused	focus	VERB
gs-3960	290	9	on	on	ADP
gs-3960	290	10	mitochondrial	mitochondrial	ADJ
gs-3960	290	11	dna	dna	NOUN
gs-3960	290	12	mutations	mutation	NOUN
gs-3960	290	13	,	,	PUNCT
gs-3960	290	14	new	new	ADJ
gs-3960	290	15	research	research	NOUN
gs-3960	290	16	highlights	highlight	VERB
gs-3960	290	17	the	the	DET
gs-3960	290	18	importance	importance	NOUN
gs-3960	290	19	of	of	ADP
gs-3960	290	20	mitochondrial	mitochondrial	ADJ
gs-3960	290	21	rna	rna	NOUN
gs-3960	290	22	metabolism	metabolism	NOUN
gs-3960	290	23	in	in	ADP
gs-3960	290	24	parkinson	parkinson	NOUN
gs-3960	290	25	's	's	PART
gs-3960	290	26	disease	disease	NOUN
gs-3960	290	27	.	.	PUNCT
gs-3960	291	1	mitochondria	mitochondria	PROPN
gs-3960	291	2	contain	contain	VERB
gs-3960	291	3	their	their	PRON
gs-3960	291	4	own	own	ADJ
gs-3960	291	5	specialized	specialized	ADJ
gs-3960	291	6	rna	rna	NOUN
gs-3960	291	7	granules	granule	NOUN
gs-3960	291	8	for	for	ADP
gs-3960	291	9	processing	processing	NOUN
gs-3960	291	10	transcripts	transcript	NOUN
gs-3960	291	11	,	,	PUNCT
gs-3960	291	12	and	and	CCONJ
gs-3960	291	13	these	these	DET
gs-3960	291	14	structures	structure	NOUN
gs-3960	291	15	appear	appear	VERB
gs-3960	291	16	disorganized	disorganized	ADJ
gs-3960	291	17	in	in	ADP
gs-3960	291	18	parkinson	parkinson	NOUN
gs-3960	291	19	's	's	PART
gs-3960	291	20	patient	patient	ADJ
gs-3960	291	21	neurons	neuron	NOUN
gs-3960	291	22	.	.	PUNCT
gs-3960	292	1	this	this	PRON
gs-3960	292	2	leads	lead	VERB
gs-3960	292	3	to	to	ADP
gs-3960	292	4	improper	improper	ADJ
gs-3960	292	5	maturation	maturation	NOUN
gs-3960	292	6	of	of	ADP
gs-3960	292	7	mitochondrial	mitochondrial	ADJ
gs-3960	292	8	-	-	PUNCT
gs-3960	292	9	encoded	encode	VERB
gs-3960	292	10	electron	electron	NOUN
gs-3960	292	11	transport	transport	NOUN
gs-3960	292	12	chain	chain	NOUN
gs-3960	292	13	components	component	NOUN
gs-3960	292	14	,	,	PUNCT
gs-3960	292	15	creating	create	VERB
gs-3960	292	16	stoichiometric	stoichiometric	ADJ
gs-3960	292	17	imbalances	imbalance	NOUN
gs-3960	292	18	in	in	ADP
gs-3960	292	19	complex	complex	ADJ
gs-3960	292	20	assembly	assembly	NOUN
gs-3960	292	21	.	.	PUNCT
gs-3960	293	1	small	small	ADJ
gs-3960	293	2	molecules	molecule	NOUN
gs-3960	293	3	that	that	PRON
gs-3960	293	4	stabilize	stabilize	VERB
gs-3960	293	5	mitochondrial	mitochondrial	ADJ
gs-3960	293	6	rna	rna	NOUN
gs-3960	293	7	processing	processing	NOUN
gs-3960	293	8	can	can	AUX
gs-3960	293	9	partially	partially	ADV
gs-3960	293	10	rescue	rescue	VERB
gs-3960	293	11	respiratory	respiratory	ADJ
gs-3960	293	12	defects	defect	NOUN
gs-3960	293	13	in	in	ADP
gs-3960	293	14	patient	patient	NOUN
gs-3960	293	15	-	-	PUNCT
gs-3960	293	16	derived	derive	VERB
gs-3960	293	17	neurons	neuron	NOUN
gs-3960	293	18	,	,	PUNCT
gs-3960	293	19	suggesting	suggest	VERB
gs-3960	293	20	this	this	PRON
gs-3960	293	21	may	may	AUX
gs-3960	293	22	be	be	AUX
gs-3960	293	23	a	a	DET
gs-3960	293	24	viable	viable	ADJ
gs-3960	293	25	therapeutic	therapeutic	ADJ
gs-3960	293	26	target	target	NOUN
gs-3960	293	27	.	.	PUNCT
gs-3960	294	1	additionally	additionally	ADV
gs-3960	294	2	,	,	PUNCT
gs-3960	294	3	certain	certain	ADJ
gs-3960	294	4	non	non	ADJ
gs-3960	294	5	-	-	ADJ
gs-3960	294	6	coding	coding	ADJ
gs-3960	294	7	rnas	rna	NOUN
gs-3960	294	8	derived	derive	VERB
gs-3960	294	9	from	from	ADP
gs-3960	294	10	the	the	DET
gs-3960	294	11	mitochondrial	mitochondrial	ADJ
gs-3960	294	12	genome	genome	NOUN
gs-3960	294	13	appear	appear	VERB
gs-3960	294	14	to	to	PART
gs-3960	294	15	have	have	VERB
gs-3960	294	16	signaling	signal	VERB
gs-3960	294	17	functions	function	NOUN
gs-3960	294	18	that	that	PRON
gs-3960	294	19	influence	influence	VERB
gs-3960	294	20	neuronal	neuronal	ADJ
gs-3960	294	21	survival	survival	NOUN
gs-3960	294	22	,	,	PUNCT
gs-3960	294	23	opening	open	VERB
gs-3960	294	24	up	up	ADP
gs-3960	294	25	yet	yet	ADV
gs-3960	294	26	another	another	DET
gs-3960	294	27	dimension	dimension	NOUN
gs-3960	294	28	of	of	ADP
gs-3960	294	29	mitochondrial	mitochondrial	ADJ
gs-3960	294	30	regulation	regulation	NOUN
gs-3960	294	31	relevant	relevant	ADJ
gs-3960	294	32	to	to	ADP
gs-3960	294	33	parkinson	parkinson	NOUN
gs-3960	294	34	's	's	PART
gs-3960	294	35	pathogenesis	pathogenesis	NOUN
gs-3960	294	36	.	.	PUNCT
gs-3960	295	1	the	the	DET
gs-3960	295	2	future	future	NOUN
gs-3960	295	3	of	of	ADP
gs-3960	295	4	mitochondrial	mitochondrial	ADJ
gs-3960	295	5	medicine	medicine	NOUN
gs-3960	295	6	for	for	ADP
gs-3960	295	7	parkinson	parkinson	NOUN
gs-3960	295	8	's	's	PART
gs-3960	295	9	disease	disease	NOUN
gs-3960	295	10	as	as	ADP
gs-3960	295	11	our	our	PRON
gs-3960	295	12	understanding	understanding	NOUN
gs-3960	295	13	of	of	ADP
gs-3960	295	14	mitochondrial	mitochondrial	ADJ
gs-3960	295	15	dysfunction	dysfunction	NOUN
gs-3960	295	16	in	in	ADP
gs-3960	295	17	parkinson	parkinson	NOUN
gs-3960	295	18	's	's	PART
gs-3960	295	19	disease	disease	NOUN
gs-3960	295	20	grows	grow	VERB
gs-3960	295	21	more	more	ADV
gs-3960	295	22	sophisticated	sophisticated	ADJ
gs-3960	295	23	,	,	PUNCT
gs-3960	295	24	so	so	ADV
gs-3960	295	25	too	too	ADV
gs-3960	295	26	do	do	VERB
gs-3960	295	27	the	the	DET
gs-3960	295	28	therapeutic	therapeutic	ADJ
gs-3960	295	29	opportunities	opportunity	NOUN
gs-3960	295	30	.	.	PUNCT
gs-3960	296	1	next	next	ADJ
gs-3960	296	2	-	-	PUNCT
gs-3960	296	3	generation	generation	NOUN
gs-3960	296	4	approaches	approach	NOUN
gs-3960	296	5	now	now	ADV
gs-3960	296	6	in	in	ADP
gs-3960	296	7	development	development	NOUN
gs-3960	296	8	include	include	VERB
gs-3960	296	9	:	:	PUNCT
gs-3960	296	10	mitochondria	mitochondria	NOUN
gs-3960	296	11	-	-	PUNCT
gs-3960	296	12	targeted	target	VERB
gs-3960	296	13	gene	gene	NOUN
gs-3960	296	14	editing	edit	VERB
gs-3960	296	15	using	use	VERB
gs-3960	296	16	novel	novel	ADJ
gs-3960	296	17	crispr	crispr	NOUN
gs-3960	296	18	systems	system	NOUN
gs-3960	296	19	adapted	adapt	VERB
gs-3960	296	20	for	for	ADP
gs-3960	296	21	mitochondrial	mitochondrial	ADJ
gs-3960	296	22	dna	dna	PROPN
gs-3960	296	23	nanotechnology	nanotechnology	NOUN
gs-3960	296	24	-	-	PUNCT
gs-3960	296	25	based	base	VERB
gs-3960	296	26	delivery	delivery	NOUN
gs-3960	296	27	of	of	ADP
gs-3960	296	28	intact	intact	ADJ
gs-3960	296	29	mitochondrial	mitochondrial	ADJ
gs-3960	296	30	complexes	complex	NOUN
gs-3960	296	31	to	to	PART
gs-3960	296	32	rescue	rescue	VERB
gs-3960	296	33	respiratory	respiratory	ADJ
gs-3960	296	34	function	function	NOUN
gs-3960	296	35	small	small	ADJ
gs-3960	296	36	molecules	molecule	NOUN
gs-3960	296	37	that	that	PRON
gs-3960	296	38	selectively	selectively	ADV
gs-3960	296	39	modulate	modulate	VERB
gs-3960	296	40	mitochondrial	mitochondrial	ADJ
gs-3960	296	41	protein	protein	NOUN
gs-3960	296	42	import	import	NOUN
gs-3960	296	43	machinery	machinery	NOUN
gs-3960	296	44	pharmacological	pharmacological	NOUN
gs-3960	296	45	chaperones	chaperone	NOUN
gs-3960	296	46	to	to	PART
gs-3960	296	47	stabilize	stabilize	VERB
gs-3960	296	48	the	the	DET
gs-3960	296	49	mitochondrial	mitochondrial	ADJ
gs-3960	296	50	proteome	proteome	NOUN
gs-3960	296	51	under	under	ADP
gs-3960	296	52	stress	stress	NOUN
gs-3960	296	53	conditions	condition	NOUN
gs-3960	296	54	georgian	georgian	NOUN
gs-3960	296	55	scientists/	scientists/	NUM
gs-3960	296	56	.	.	PUNCT
gs-3960	297	1	7	7	NUM
gs-3960	297	2	n	n	PRON
gs-3960	297	3	3	3	NUM
gs-3960	297	4	,	,	PUNCT
gs-3960	297	5	2025	2025	NUM
gs-3960	297	6	416	416	NUM
gs-3960	297	7	bioelectronic	bioelectronic	ADJ
gs-3960	297	8	devices	device	NOUN
gs-3960	297	9	that	that	PRON
gs-3960	297	10	modulate	modulate	VERB
gs-3960	297	11	neuronal	neuronal	ADJ
gs-3960	297	12	activity	activity	NOUN
gs-3960	297	13	patterns	pattern	NOUN
gs-3960	297	14	to	to	PART
gs-3960	297	15	reduce	reduce	VERB
gs-3960	297	16	mitochondrial	mitochondrial	ADJ
gs-3960	297	17	stress	stress	NOUN
gs-3960	297	18	the	the	DET
gs-3960	297	19	convergence	convergence	NOUN
gs-3960	297	20	of	of	ADP
gs-3960	297	21	these	these	DET
gs-3960	297	22	innovative	innovative	ADJ
gs-3960	297	23	approaches	approach	NOUN
gs-3960	297	24	with	with	ADP
gs-3960	297	25	traditional	traditional	ADJ
gs-3960	297	26	strategies	strategy	NOUN
gs-3960	297	27	targeting	target	VERB
gs-3960	297	28	mitophagy	mitophagy	NOUN
gs-3960	297	29	and	and	CCONJ
gs-3960	297	30	nad+	nad+	PROPN
gs-3960	297	31	metabolism	metabolism	NOUN
gs-3960	297	32	creates	create	VERB
gs-3960	297	33	an	an	DET
gs-3960	297	34	unprecedented	unprecedented	ADJ
gs-3960	297	35	opportunity	opportunity	NOUN
gs-3960	297	36	to	to	PART
gs-3960	297	37	develop	develop	VERB
gs-3960	297	38	truly	truly	ADV
gs-3960	297	39	disease	disease	NOUN
gs-3960	297	40	-	-	PUNCT
gs-3960	297	41	modifying	modify	VERB
gs-3960	297	42	therapies	therapy	NOUN
gs-3960	297	43	.	.	PUNCT
gs-3960	298	1	as	as	SCONJ
gs-3960	298	2	we	we	PRON
gs-3960	298	3	move	move	VERB
gs-3960	298	4	forward	forward	ADV
gs-3960	298	5	,	,	PUNCT
gs-3960	298	6	the	the	DET
gs-3960	298	7	challenge	challenge	NOUN
gs-3960	298	8	will	will	AUX
gs-3960	298	9	be	be	AUX
gs-3960	298	10	to	to	PART
gs-3960	298	11	integrate	integrate	VERB
gs-3960	298	12	these	these	DET
gs-3960	298	13	diverse	diverse	ADJ
gs-3960	298	14	insights	insight	NOUN
gs-3960	298	15	into	into	ADP
gs-3960	298	16	coherent	coherent	ADJ
gs-3960	298	17	treatment	treatment	NOUN
gs-3960	298	18	paradigms	paradigm	NOUN
gs-3960	298	19	that	that	PRON
gs-3960	298	20	address	address	VERB
gs-3960	298	21	the	the	DET
gs-3960	298	22	multifaceted	multifaceted	ADJ
gs-3960	298	23	nature	nature	NOUN
gs-3960	298	24	of	of	ADP
gs-3960	298	25	mitochondrial	mitochondrial	ADJ
gs-3960	298	26	dysfunction	dysfunction	NOUN
gs-3960	298	27	in	in	ADP
gs-3960	298	28	parkinson	parkinson	NOUN
gs-3960	298	29	's	's	PART
gs-3960	298	30	disease	disease	NOUN
gs-3960	298	31	.	.	PUNCT
gs-3960	299	1	this	this	DET
gs-3960	299	2	rapidly	rapidly	ADV
gs-3960	299	3	evolving	evolve	VERB
gs-3960	299	4	field	field	NOUN
gs-3960	299	5	continues	continue	VERB
gs-3960	299	6	to	to	PART
gs-3960	299	7	surprise	surprise	VERB
gs-3960	299	8	and	and	CCONJ
gs-3960	299	9	challenge	challenge	NOUN
gs-3960	299	10	researchers	researcher	NOUN
gs-3960	299	11	,	,	PUNCT
gs-3960	299	12	with	with	ADP
gs-3960	299	13	each	each	DET
gs-3960	299	14	new	new	ADJ
gs-3960	299	15	discovery	discovery	NOUN
gs-3960	299	16	revealing	reveal	VERB
gs-3960	299	17	additional	additional	ADJ
gs-3960	299	18	layers	layer	NOUN
gs-3960	299	19	of	of	ADP
gs-3960	299	20	complexity	complexity	NOUN
gs-3960	299	21	in	in	ADP
gs-3960	299	22	the	the	DET
gs-3960	299	23	relationship	relationship	NOUN
gs-3960	299	24	between	between	ADP
gs-3960	299	25	mitochondrial	mitochondrial	ADJ
gs-3960	299	26	health	health	NOUN
gs-3960	299	27	and	and	CCONJ
gs-3960	299	28	neuronal	neuronal	ADJ
gs-3960	299	29	survival	survival	NOUN
gs-3960	299	30	.	.	PUNCT
gs-3960	300	1	what	what	PRON
gs-3960	300	2	remains	remain	VERB
gs-3960	300	3	clear	clear	ADJ
gs-3960	300	4	is	be	AUX
gs-3960	300	5	that	that	SCONJ
gs-3960	300	6	maintaining	maintain	VERB
gs-3960	300	7	or	or	CCONJ
gs-3960	300	8	restoring	restore	VERB
gs-3960	300	9	mitochondrial	mitochondrial	ADJ
gs-3960	300	10	function	function	NOUN
gs-3960	300	11	represents	represent	VERB
gs-3960	300	12	one	one	NUM
gs-3960	300	13	of	of	ADP
gs-3960	300	14	the	the	DET
gs-3960	300	15	most	most	ADV
gs-3960	300	16	promising	promising	ADJ
gs-3960	300	17	avenues	avenue	NOUN
gs-3960	300	18	for	for	ADP
gs-3960	300	19	developing	develop	VERB
gs-3960	300	20	effective	effective	ADJ
gs-3960	300	21	treatments	treatment	NOUN
gs-3960	300	22	that	that	PRON
gs-3960	300	23	can	can	AUX
gs-3960	300	24	slow	slow	VERB
gs-3960	300	25	or	or	CCONJ
gs-3960	300	26	halt	halt	VERB
gs-3960	300	27	parkinson	parkinson	NOUN
gs-3960	300	28	's	's	PART
gs-3960	300	29	progression	progression	NOUN
gs-3960	300	30	.	.	PUNCT
gs-3960	301	1	the	the	DET
gs-3960	301	2	coming	come	VERB
gs-3960	301	3	years	year	NOUN
gs-3960	301	4	will	will	AUX
gs-3960	301	5	undoubtedly	undoubtedly	ADV
gs-3960	301	6	bring	bring	VERB
gs-3960	301	7	both	both	CCONJ
gs-3960	301	8	deeper	deep	ADJ
gs-3960	301	9	understanding	understanding	NOUN
gs-3960	301	10	and	and	CCONJ
gs-3960	301	11	more	more	ADV
gs-3960	301	12	sophisticated	sophisticated	ADJ
gs-3960	301	13	therapeutic	therapeutic	ADJ
gs-3960	301	14	strategies	strategy	NOUN
gs-3960	301	15	as	as	SCONJ
gs-3960	301	16	we	we	PRON
gs-3960	301	17	continue	continue	VERB
gs-3960	301	18	to	to	PART
gs-3960	301	19	unravel	unravel	VERB
gs-3960	301	20	the	the	DET
gs-3960	301	21	mysteries	mystery	NOUN
gs-3960	301	22	of	of	ADP
gs-3960	301	23	mitochondria	mitochondria	NOUN
gs-3960	301	24	in	in	ADP
gs-3960	301	25	health	health	NOUN
gs-3960	301	26	and	and	CCONJ
gs-3960	301	27	disease	disease	NOUN
gs-3960	302	1	[	[	X
gs-3960	302	2	16,19,27,78	16,19,27,78	NUM
gs-3960	302	3	]	]	PUNCT
gs-3960	302	4	.	.	PUNCT
gs-3960	303	1	the	the	DET
gs-3960	303	2	evolving	evolve	VERB
gs-3960	303	3	paradigm	paradigm	NOUN
gs-3960	303	4	of	of	ADP
gs-3960	303	5	mitochondrial	mitochondrial	ADJ
gs-3960	303	6	pathobiology	pathobiology	NOUN
gs-3960	303	7	in	in	ADP
gs-3960	303	8	parkinson	parkinson	NOUN
gs-3960	303	9	's	's	PART
gs-3960	303	10	disease	disease	NOUN
gs-3960	303	11	:	:	PUNCT
gs-3960	303	12	from	from	ADP
gs-3960	303	13	molecular	molecular	ADJ
gs-3960	303	14	insights	insight	NOUN
gs-3960	303	15	to	to	ADP
gs-3960	303	16	therapeutic	therapeutic	ADJ
gs-3960	303	17	innovation	innovation	NOUN
gs-3960	303	18	the	the	DET
gs-3960	303	19	relentless	relentless	ADJ
gs-3960	303	20	progression	progression	NOUN
gs-3960	303	21	of	of	ADP
gs-3960	303	22	parkinson	parkinson	NOUN
gs-3960	303	23	's	's	PART
gs-3960	303	24	disease	disease	NOUN
gs-3960	303	25	,	,	PUNCT
gs-3960	303	26	marked	mark	VERB
gs-3960	303	27	by	by	ADP
gs-3960	303	28	the	the	DET
gs-3960	303	29	selective	selective	ADJ
gs-3960	303	30	vulnerability	vulnerability	NOUN
gs-3960	303	31	of	of	ADP
gs-3960	303	32	dopaminergic	dopaminergic	ADJ
gs-3960	303	33	neurons	neuron	NOUN
gs-3960	303	34	in	in	ADP
gs-3960	303	35	the	the	DET
gs-3960	303	36	substantia	substantia	NOUN
gs-3960	303	37	nigra	nigra	NOUN
gs-3960	303	38	,	,	PUNCT
gs-3960	303	39	has	have	AUX
gs-3960	303	40	increasingly	increasingly	ADV
gs-3960	303	41	been	be	AUX
gs-3960	303	42	recognized	recognize	VERB
gs-3960	303	43	as	as	ADP
gs-3960	303	44	a	a	DET
gs-3960	303	45	disorder	disorder	NOUN
gs-3960	303	46	of	of	ADP
gs-3960	303	47	mitochondrial	mitochondrial	ADJ
gs-3960	303	48	network	network	NOUN
gs-3960	303	49	failure	failure	NOUN
gs-3960	303	50	.	.	PUNCT
gs-3960	304	1	this	this	PRON
gs-3960	304	2	expanded	expand	VERB
gs-3960	304	3	understanding	understanding	NOUN
gs-3960	304	4	moves	move	NOUN
gs-3960	304	5	beyond	beyond	ADP
gs-3960	304	6	simplistic	simplistic	ADJ
gs-3960	304	7	energy	energy	NOUN
gs-3960	304	8	deficiency	deficiency	NOUN
gs-3960	304	9	models	model	NOUN
gs-3960	304	10	to	to	PART
gs-3960	304	11	encompass	encompass	VERB
gs-3960	304	12	a	a	DET
gs-3960	304	13	sophisticated	sophisticated	ADJ
gs-3960	304	14	view	view	NOUN
gs-3960	304	15	of	of	ADP
gs-3960	304	16	mitochondria	mitochondria	NOUN
gs-3960	304	17	as	as	ADP
gs-3960	304	18	dynamic	dynamic	ADJ
gs-3960	304	19	signaling	signal	VERB
gs-3960	304	20	organelles	organelle	NOUN
gs-3960	304	21	that	that	PRON
gs-3960	304	22	integrate	integrate	VERB
gs-3960	304	23	metabolic	metabolic	NOUN
gs-3960	304	24	,	,	PUNCT
gs-3960	304	25	proteostatic	proteostatic	NOUN
gs-3960	304	26	,	,	PUNCT
gs-3960	304	27	and	and	CCONJ
gs-3960	304	28	inflammatory	inflammatory	ADJ
gs-3960	304	29	information	information	NOUN
gs-3960	304	30	.	.	PUNCT
gs-3960	305	1	recent	recent	ADJ
gs-3960	305	2	breakthroughs	breakthrough	NOUN
gs-3960	305	3	have	have	AUX
gs-3960	305	4	revealed	reveal	VERB
gs-3960	305	5	unexpected	unexpected	ADJ
gs-3960	305	6	dimensions	dimension	NOUN
gs-3960	305	7	of	of	ADP
gs-3960	305	8	mitochondrial	mitochondrial	ADJ
gs-3960	305	9	involvement	involvement	NOUN
gs-3960	305	10	in	in	ADP
gs-3960	305	11	parkinson	parkinson	NOUN
gs-3960	305	12	's	's	PART
gs-3960	305	13	pathogenesis	pathogenesis	NOUN
gs-3960	305	14	,	,	PUNCT
gs-3960	305	15	offering	offer	VERB
gs-3960	305	16	fresh	fresh	ADJ
gs-3960	305	17	perspectives	perspective	NOUN
gs-3960	305	18	on	on	ADP
gs-3960	305	19	disease	disease	NOUN
gs-3960	305	20	mechanisms	mechanism	NOUN
gs-3960	305	21	and	and	CCONJ
gs-3960	305	22	therapeutic	therapeutic	ADJ
gs-3960	305	23	opportunities	opportunity	NOUN
gs-3960	305	24	.	.	PUNCT
gs-3960	306	1	mitochondrial	mitochondrial	ADJ
gs-3960	306	2	surface	surface	NOUN
gs-3960	306	3	topology	topology	NOUN
gs-3960	306	4	and	and	CCONJ
gs-3960	306	5	protein	protein	NOUN
gs-3960	306	6	import	import	NOUN
gs-3960	306	7	dysregulation	dysregulation	NOUN
gs-3960	306	8	novel	novel	NOUN
gs-3960	306	9	investigations	investigation	NOUN
gs-3960	306	10	into	into	ADP
gs-3960	306	11	mitochondrial	mitochondrial	ADJ
gs-3960	306	12	surface	surface	NOUN
gs-3960	306	13	architecture	architecture	NOUN
gs-3960	306	14	have	have	AUX
gs-3960	306	15	uncovered	uncover	VERB
gs-3960	306	16	profound	profound	ADJ
gs-3960	306	17	alterations	alteration	NOUN
gs-3960	306	18	in	in	ADP
gs-3960	306	19	parkinson	parkinson	NOUN
gs-3960	306	20	's	's	PART
gs-3960	306	21	disease	disease	NOUN
gs-3960	306	22	neurons	neuron	NOUN
gs-3960	306	23	.	.	PUNCT
gs-3960	307	1	the	the	DET
gs-3960	307	2	outer	outer	ADJ
gs-3960	307	3	mitochondrial	mitochondrial	ADJ
gs-3960	307	4	membrane	membrane	NOUN
gs-3960	307	5	,	,	PUNCT
gs-3960	307	6	traditionally	traditionally	ADV
gs-3960	307	7	viewed	view	VERB
gs-3960	307	8	as	as	ADP
gs-3960	307	9	a	a	DET
gs-3960	307	10	simple	simple	ADJ
gs-3960	307	11	barrier	barrier	NOUN
gs-3960	307	12	,	,	PUNCT
gs-3960	307	13	emerges	emerge	VERB
gs-3960	307	14	as	as	ADP
gs-3960	307	15	a	a	DET
gs-3960	307	16	highly	highly	ADV
gs-3960	307	17	organized	organize	VERB
gs-3960	307	18	platform	platform	NOUN
gs-3960	307	19	for	for	ADP
gs-3960	307	20	protein	protein	NOUN
gs-3960	307	21	import	import	NOUN
gs-3960	307	22	complexes	complex	NOUN
gs-3960	307	23	and	and	CCONJ
gs-3960	307	24	signaling	signal	VERB
gs-3960	307	25	assemblies	assembly	NOUN
gs-3960	307	26	.	.	PUNCT
gs-3960	308	1	high	high	ADJ
gs-3960	308	2	-	-	PUNCT
gs-3960	308	3	resolution	resolution	NOUN
gs-3960	308	4	cryo	cryo	NOUN
gs-3960	308	5	-	-	PUNCT
gs-3960	308	6	electron	electron	NOUN
gs-3960	308	7	tomography	tomography	NOUN
gs-3960	308	8	studies	study	NOUN
gs-3960	308	9	demonstrate	demonstrate	VERB
gs-3960	308	10	that	that	SCONJ
gs-3960	308	11	parkinson's	parkinson's	NOUN
gs-3960	308	12	-	-	PUNCT
gs-3960	308	13	associated	associate	VERB
gs-3960	308	14	mutations	mutation	NOUN
gs-3960	308	15	in	in	ADP
gs-3960	308	16	genes	gene	NOUN
gs-3960	308	17	like	like	ADP
gs-3960	308	18	pink1	pink1	NOUN
gs-3960	308	19	and	and	CCONJ
gs-3960	308	20	dj-1	dj-1	ADV
gs-3960	308	21	cause	cause	VERB
gs-3960	308	22	specific	specific	ADJ
gs-3960	308	23	distortions	distortion	NOUN
gs-3960	308	24	in	in	ADP
gs-3960	308	25	the	the	DET
gs-3960	308	26	translocase	translocase	NOUN
gs-3960	308	27	of	of	ADP
gs-3960	308	28	the	the	DET
gs-3960	308	29	outer	outer	ADJ
gs-3960	308	30	membrane	membrane	NOUN
gs-3960	308	31	(	(	PUNCT
gs-3960	308	32	tom	tom	NOUN
gs-3960	308	33	)	)	PUNCT
gs-3960	308	34	complex	complex	ADJ
gs-3960	308	35	architecture	architecture	NOUN
gs-3960	308	36	.	.	PUNCT
gs-3960	309	1	these	these	DET
gs-3960	309	2	structural	structural	ADJ
gs-3960	309	3	changes	change	NOUN
gs-3960	309	4	impair	impair	VERB
gs-3960	309	5	the	the	DET
gs-3960	309	6	import	import	NOUN
gs-3960	309	7	of	of	ADP
gs-3960	309	8	nuclear	nuclear	NOUN
gs-3960	309	9	-	-	PUNCT
gs-3960	309	10	encoded	encode	VERB
gs-3960	309	11	mitochondrial	mitochondrial	ADJ
gs-3960	309	12	proteins	protein	NOUN
gs-3960	309	13	,	,	PUNCT
gs-3960	309	14	creating	create	VERB
gs-3960	309	15	a	a	DET
gs-3960	309	16	proteostatic	proteostatic	ADJ
gs-3960	309	17	crisis	crisis	NOUN
gs-3960	309	18	that	that	PRON
gs-3960	309	19	extends	extend	VERB
gs-3960	309	20	beyond	beyond	ADP
gs-3960	309	21	the	the	DET
gs-3960	309	22	organelle	organelle	NOUN
gs-3960	309	23	itself	itself	PRON
gs-3960	309	24	.	.	PUNCT
gs-3960	310	1	the	the	DET
gs-3960	310	2	consequences	consequence	NOUN
gs-3960	310	3	of	of	ADP
gs-3960	310	4	this	this	DET
gs-3960	310	5	import	import	NOUN
gs-3960	310	6	failure	failure	NOUN
gs-3960	310	7	are	be	AUX
gs-3960	310	8	particularly	particularly	ADV
gs-3960	310	9	severe	severe	ADJ
gs-3960	310	10	for	for	ADP
gs-3960	310	11	dopaminergic	dopaminergic	ADJ
gs-3960	310	12	neurons	neuron	NOUN
gs-3960	310	13	due	due	ADP
gs-3960	310	14	to	to	ADP
gs-3960	310	15	their	their	PRON
gs-3960	310	16	exceptional	exceptional	ADJ
gs-3960	310	17	reliance	reliance	NOUN
gs-3960	310	18	on	on	ADP
gs-3960	310	19	mitochondrial	mitochondrial	ADJ
gs-3960	310	20	-	-	PUNCT
gs-3960	310	21	encoded	encode	VERB
gs-3960	310	22	proteins	protein	NOUN
gs-3960	310	23	for	for	ADP
gs-3960	310	24	neurotransmitter	neurotransmitter	NOUN
gs-3960	310	25	synthesis	synthesis	NOUN
gs-3960	310	26	and	and	CCONJ
gs-3960	310	27	calcium	calcium	NOUN
gs-3960	310	28	handling	handling	NOUN
gs-3960	310	29	.	.	PUNCT
gs-3960	311	1	proteomic	proteomic	ADJ
gs-3960	311	2	analyses	analysis	NOUN
gs-3960	311	3	reveal	reveal	VERB
gs-3960	311	4	that	that	SCONJ
gs-3960	311	5	certain	certain	ADJ
gs-3960	311	6	classes	class	NOUN
gs-3960	311	7	of	of	ADP
gs-3960	311	8	mitochondrial	mitochondrial	ADJ
gs-3960	311	9	precursor	precursor	NOUN
gs-3960	311	10	proteins	protein	NOUN
gs-3960	311	11	accumulate	accumulate	VERB
gs-3960	311	12	in	in	ADP
gs-3960	311	13	the	the	DET
gs-3960	311	14	cytosol	cytosol	NOUN
gs-3960	311	15	of	of	ADP
gs-3960	311	16	parkinson	parkinson	NOUN
gs-3960	311	17	's	's	PART
gs-3960	311	18	patient	patient	ADJ
gs-3960	311	19	georgian	georgian	NOUN
gs-3960	311	20	scientists/	scientists/	NUM
gs-3960	311	21	.	.	PUNCT
gs-3960	312	1	7	7	NUM
gs-3960	312	2	n	n	PRON
gs-3960	312	3	3	3	NUM
gs-3960	312	4	,	,	PUNCT
gs-3960	312	5	2025	2025	NUM
gs-3960	312	6	417	417	NUM
gs-3960	312	7	neurons	neuron	NOUN
gs-3960	312	8	,	,	PUNCT
gs-3960	312	9	forming	form	VERB
gs-3960	312	10	aberrant	aberrant	ADJ
gs-3960	312	11	aggregates	aggregate	NOUN
gs-3960	312	12	that	that	PRON
gs-3960	312	13	may	may	AUX
gs-3960	312	14	contribute	contribute	VERB
gs-3960	312	15	to	to	ADP
gs-3960	312	16	the	the	DET
gs-3960	312	17	observed	observed	ADJ
gs-3960	312	18	pathology	pathology	NOUN
gs-3960	312	19	.	.	PUNCT
gs-3960	313	1	this	this	DET
gs-3960	313	2	discovery	discovery	NOUN
gs-3960	313	3	fundamentally	fundamentally	ADV
gs-3960	313	4	changes	change	VERB
gs-3960	313	5	our	our	PRON
gs-3960	313	6	understanding	understanding	NOUN
gs-3960	313	7	of	of	ADP
gs-3960	313	8	protein	protein	NOUN
gs-3960	313	9	misfolding	misfolde	VERB
gs-3960	313	10	in	in	ADP
gs-3960	313	11	parkinson	parkinson	NOUN
gs-3960	313	12	's	's	PART
gs-3960	313	13	,	,	PUNCT
gs-3960	313	14	suggesting	suggest	VERB
gs-3960	313	15	that	that	SCONJ
gs-3960	313	16	some	some	DET
gs-3960	313	17	alpha	alpha	NOUN
gs-3960	313	18	-	-	PUNCT
gs-3960	313	19	synuclein	synuclein	NOUN
gs-3960	313	20	aggregation	aggregation	NOUN
gs-3960	313	21	may	may	AUX
gs-3960	313	22	be	be	AUX
gs-3960	313	23	secondary	secondary	ADJ
gs-3960	313	24	to	to	ADP
gs-3960	313	25	primary	primary	ADJ
gs-3960	313	26	mitochondrial	mitochondrial	ADJ
gs-3960	313	27	import	import	NOUN
gs-3960	313	28	defects	defect	NOUN
gs-3960	313	29	.	.	PUNCT
gs-3960	314	1	mitochondrial	mitochondrial	ADJ
gs-3960	314	2	membrane	membrane	NOUN
gs-3960	314	3	fluidity	fluidity	NOUN
gs-3960	314	4	and	and	CCONJ
gs-3960	314	5	lipid	lipid	NOUN
gs-3960	314	6	signaling	signal	VERB
gs-3960	314	7	advanced	advanced	ADJ
gs-3960	314	8	lipidomics	lipidomic	NOUN
gs-3960	314	9	approaches	approach	NOUN
gs-3960	314	10	have	have	AUX
gs-3960	314	11	identified	identify	VERB
gs-3960	314	12	striking	striking	ADJ
gs-3960	314	13	alterations	alteration	NOUN
gs-3960	314	14	in	in	ADP
gs-3960	314	15	mitochondrial	mitochondrial	ADJ
gs-3960	314	16	membrane	membrane	NOUN
gs-3960	314	17	composition	composition	NOUN
gs-3960	314	18	in	in	ADP
gs-3960	314	19	parkinson	parkinson	NOUN
gs-3960	314	20	's	's	PART
gs-3960	314	21	disease	disease	NOUN
gs-3960	314	22	.	.	PUNCT
gs-3960	315	1	the	the	DET
gs-3960	315	2	unique	unique	ADJ
gs-3960	315	3	lipid	lipid	NOUN
gs-3960	315	4	microenvironment	microenvironment	NOUN
gs-3960	315	5	of	of	ADP
gs-3960	315	6	mitochondrial	mitochondrial	ADJ
gs-3960	315	7	membranes	membrane	NOUN
gs-3960	315	8	,	,	PUNCT
gs-3960	315	9	particularly	particularly	ADV
gs-3960	315	10	the	the	DET
gs-3960	315	11	abundance	abundance	NOUN
gs-3960	315	12	of	of	ADP
gs-3960	315	13	cardiolipin	cardiolipin	NOUN
gs-3960	315	14	and	and	CCONJ
gs-3960	315	15	its	its	PRON
gs-3960	315	16	oxidation	oxidation	NOUN
gs-3960	315	17	products	product	NOUN
gs-3960	315	18	,	,	PUNCT
gs-3960	315	19	appears	appear	VERB
gs-3960	315	20	crucial	crucial	ADJ
gs-3960	315	21	for	for	ADP
gs-3960	315	22	maintaining	maintain	VERB
gs-3960	315	23	proper	proper	ADJ
gs-3960	315	24	respiratory	respiratory	ADJ
gs-3960	315	25	chain	chain	NOUN
gs-3960	315	26	supercomplex	supercomplex	PROPN
gs-3960	315	27	organization	organization	NOUN
gs-3960	315	28	.	.	PUNCT
gs-3960	316	1	in	in	ADP
gs-3960	316	2	parkinson	parkinson	NOUN
gs-3960	316	3	's	's	PART
gs-3960	316	4	neurons	neuron	NOUN
gs-3960	316	5	,	,	PUNCT
gs-3960	316	6	there	there	PRON
gs-3960	316	7	is	be	VERB
gs-3960	316	8	a	a	DET
gs-3960	316	9	significant	significant	ADJ
gs-3960	316	10	shift	shift	NOUN
gs-3960	316	11	toward	toward	ADP
gs-3960	316	12	more	more	ADV
gs-3960	316	13	saturated	saturated	ADJ
gs-3960	316	14	lipid	lipid	NOUN
gs-3960	316	15	species	specie	NOUN
gs-3960	316	16	,	,	PUNCT
gs-3960	316	17	reducing	reduce	VERB
gs-3960	316	18	membrane	membrane	NOUN
gs-3960	316	19	fluidity	fluidity	NOUN
gs-3960	316	20	and	and	CCONJ
gs-3960	316	21	impairing	impair	VERB
gs-3960	316	22	the	the	DET
gs-3960	316	23	dynamic	dynamic	ADJ
gs-3960	316	24	reorganization	reorganization	NOUN
gs-3960	316	25	of	of	ADP
gs-3960	316	26	electron	electron	NOUN
gs-3960	316	27	transport	transport	NOUN
gs-3960	316	28	chain	chain	NOUN
gs-3960	316	29	components	component	NOUN
gs-3960	316	30	during	during	ADP
gs-3960	316	31	changes	change	NOUN
gs-3960	316	32	in	in	ADP
gs-3960	316	33	energy	energy	NOUN
gs-3960	316	34	demand	demand	NOUN
gs-3960	316	35	.	.	PUNCT
gs-3960	317	1	this	this	DET
gs-3960	317	2	lipid	lipid	NOUN
gs-3960	317	3	dysregulation	dysregulation	NOUN
gs-3960	317	4	creates	create	VERB
gs-3960	317	5	a	a	DET
gs-3960	317	6	self	self	NOUN
gs-3960	317	7	-	-	PUNCT
gs-3960	317	8	amplifying	amplify	VERB
gs-3960	317	9	cycle	cycle	NOUN
gs-3960	317	10	where	where	SCONJ
gs-3960	317	11	decreased	decrease	VERB
gs-3960	317	12	membrane	membrane	NOUN
gs-3960	317	13	fluidity	fluidity	NOUN
gs-3960	317	14	reduces	reduce	VERB
gs-3960	317	15	respiratory	respiratory	ADJ
gs-3960	317	16	efficiency	efficiency	NOUN
gs-3960	317	17	,	,	PUNCT
gs-3960	317	18	leading	lead	VERB
gs-3960	317	19	to	to	ADP
gs-3960	317	20	increased	increase	VERB
gs-3960	317	21	reactive	reactive	ADJ
gs-3960	317	22	oxygen	oxygen	NOUN
gs-3960	317	23	species	species	NOUN
gs-3960	317	24	production	production	NOUN
gs-3960	317	25	,	,	PUNCT
gs-3960	317	26	which	which	PRON
gs-3960	317	27	further	far	ADV
gs-3960	317	28	damages	damage	VERB
gs-3960	317	29	membrane	membrane	NOUN
gs-3960	317	30	lipids	lipid	NOUN
gs-3960	317	31	.	.	PUNCT
gs-3960	318	1	intriguingly	intriguingly	ADV
gs-3960	318	2	,	,	PUNCT
gs-3960	318	3	certain	certain	ADJ
gs-3960	318	4	parkinson'srelated	parkinson'srelate	VERB
gs-3960	318	5	genetic	genetic	ADJ
gs-3960	318	6	variants	variant	NOUN
gs-3960	318	7	affect	affect	VERB
gs-3960	318	8	enzymes	enzyme	NOUN
gs-3960	318	9	involved	involve	VERB
gs-3960	318	10	in	in	ADP
gs-3960	318	11	mitochondrial	mitochondrial	ADJ
gs-3960	318	12	lipid	lipid	NOUN
gs-3960	318	13	metabolism	metabolism	NOUN
gs-3960	318	14	,	,	PUNCT
gs-3960	318	15	suggesting	suggest	VERB
gs-3960	318	16	this	this	PRON
gs-3960	318	17	may	may	AUX
gs-3960	318	18	be	be	AUX
gs-3960	318	19	a	a	DET
gs-3960	318	20	primary	primary	ADJ
gs-3960	318	21	pathogenic	pathogenic	ADJ
gs-3960	318	22	mechanism	mechanism	NOUN
gs-3960	318	23	in	in	ADP
gs-3960	318	24	some	some	DET
gs-3960	318	25	cases	case	NOUN
gs-3960	318	26	rather	rather	ADV
gs-3960	318	27	than	than	ADP
gs-3960	318	28	merely	merely	ADV
gs-3960	318	29	a	a	DET
gs-3960	318	30	secondary	secondary	ADJ
gs-3960	318	31	consequence	consequence	NOUN
gs-3960	318	32	of	of	ADP
gs-3960	318	33	oxidative	oxidative	ADJ
gs-3960	318	34	stress	stress	NOUN
gs-3960	318	35	.	.	PUNCT
gs-3960	319	1	the	the	DET
gs-3960	319	2	mitochondrial	mitochondrial	ADJ
gs-3960	319	3	epitranscriptome	epitranscriptome	NOUN
gs-3960	319	4	in	in	ADP
gs-3960	319	5	neuronal	neuronal	ADJ
gs-3960	319	6	vulnerability	vulnerability	NOUN
gs-3960	319	7	emerging	emerge	VERB
gs-3960	319	8	research	research	NOUN
gs-3960	319	9	on	on	ADP
gs-3960	319	10	mitochondrial	mitochondrial	ADJ
gs-3960	319	11	rna	rna	NOUN
gs-3960	319	12	modifications	modification	NOUN
gs-3960	319	13	has	have	AUX
gs-3960	319	14	uncovered	uncover	VERB
gs-3960	319	15	a	a	DET
gs-3960	319	16	previously	previously	ADV
gs-3960	319	17	unrecognized	unrecognize	VERB
gs-3960	319	18	regulatory	regulatory	ADJ
gs-3960	319	19	layer	layer	NOUN
gs-3960	319	20	in	in	ADP
gs-3960	319	21	parkinson	parkinson	NOUN
gs-3960	319	22	's	's	PART
gs-3960	319	23	disease	disease	NOUN
gs-3960	319	24	.	.	PUNCT
gs-3960	320	1	the	the	DET
gs-3960	320	2	mitochondrial	mitochondrial	ADJ
gs-3960	320	3	epitranscriptome	epitranscriptome	NOUN
gs-3960	320	4	,	,	PUNCT
gs-3960	320	5	comprising	comprise	VERB
gs-3960	320	6	various	various	ADJ
gs-3960	320	7	chemical	chemical	ADJ
gs-3960	320	8	modifications	modification	NOUN
gs-3960	320	9	to	to	ADP
gs-3960	320	10	mitochondrial	mitochondrial	ADJ
gs-3960	320	11	rnas	rna	NOUN
gs-3960	320	12	,	,	PUNCT
gs-3960	320	13	appears	appear	VERB
gs-3960	320	14	extensively	extensively	ADV
gs-3960	320	15	altered	alter	VERB
gs-3960	320	16	in	in	ADP
gs-3960	320	17	patient	patient	ADJ
gs-3960	320	18	neurons	neuron	NOUN
gs-3960	320	19	.	.	PUNCT
gs-3960	321	1	these	these	DET
gs-3960	321	2	modifications	modification	NOUN
gs-3960	321	3	influence	influence	VERB
gs-3960	321	4	the	the	DET
gs-3960	321	5	stability	stability	NOUN
gs-3960	321	6	,	,	PUNCT
gs-3960	321	7	translation	translation	NOUN
gs-3960	321	8	efficiency	efficiency	NOUN
gs-3960	321	9	,	,	PUNCT
gs-3960	321	10	and	and	CCONJ
gs-3960	321	11	even	even	ADV
gs-3960	321	12	the	the	DET
gs-3960	321	13	alternative	alternative	ADJ
gs-3960	321	14	splicing	splicing	NOUN
gs-3960	321	15	patterns	pattern	NOUN
gs-3960	321	16	of	of	ADP
gs-3960	321	17	mitochondrial	mitochondrial	ADJ
gs-3960	321	18	-	-	PUNCT
gs-3960	321	19	encoded	encode	VERB
gs-3960	321	20	transcripts	transcript	NOUN
gs-3960	321	21	.	.	PUNCT
gs-3960	322	1	specific	specific	ADJ
gs-3960	322	2	modifications	modification	NOUN
gs-3960	322	3	like	like	ADP
gs-3960	322	4	m5c	m5c	NOUN
gs-3960	322	5	on	on	ADP
gs-3960	322	6	mitochondrial	mitochondrial	ADJ
gs-3960	322	7	trna	trna	NOUN
gs-3960	322	8	have	have	AUX
gs-3960	322	9	been	be	AUX
gs-3960	322	10	shown	show	VERB
gs-3960	322	11	to	to	PART
gs-3960	322	12	affect	affect	VERB
gs-3960	322	13	the	the	DET
gs-3960	322	14	fidelity	fidelity	NOUN
gs-3960	322	15	of	of	ADP
gs-3960	322	16	mitochondrial	mitochondrial	ADJ
gs-3960	322	17	protein	protein	NOUN
gs-3960	322	18	synthesis	synthesis	NOUN
gs-3960	322	19	,	,	PUNCT
gs-3960	322	20	potentially	potentially	ADV
gs-3960	322	21	explaining	explain	VERB
gs-3960	322	22	the	the	DET
gs-3960	322	23	observed	observe	VERB
gs-3960	322	24	imbalances	imbalance	NOUN
gs-3960	322	25	in	in	ADP
gs-3960	322	26	electron	electron	NOUN
gs-3960	322	27	transport	transport	NOUN
gs-3960	322	28	chain	chain	NOUN
gs-3960	322	29	subunit	subunit	NOUN
gs-3960	322	30	stoichiometry	stoichiometry	NOUN
gs-3960	322	31	.	.	PUNCT
gs-3960	323	1	moreover	moreover	ADV
gs-3960	323	2	,	,	PUNCT
gs-3960	323	3	certain	certain	ADJ
gs-3960	323	4	modifications	modification	NOUN
gs-3960	323	5	serve	serve	VERB
gs-3960	323	6	as	as	ADP
gs-3960	323	7	signals	signal	NOUN
gs-3960	323	8	for	for	ADP
gs-3960	323	9	the	the	DET
gs-3960	323	10	selective	selective	ADJ
gs-3960	323	11	degradation	degradation	NOUN
gs-3960	323	12	of	of	ADP
gs-3960	323	13	damaged	damage	VERB
gs-3960	323	14	mitochondrial	mitochondrial	ADJ
gs-3960	323	15	transcripts	transcript	NOUN
gs-3960	323	16	,	,	PUNCT
gs-3960	323	17	a	a	DET
gs-3960	323	18	process	process	NOUN
gs-3960	323	19	that	that	PRON
gs-3960	323	20	appears	appear	VERB
gs-3960	323	21	disrupted	disrupt	VERB
gs-3960	323	22	in	in	ADP
gs-3960	323	23	parkinson	parkinson	NOUN
gs-3960	323	24	's	's	PART
gs-3960	323	25	.	.	PUNCT
gs-3960	324	1	this	this	DET
gs-3960	324	2	new	new	ADJ
gs-3960	324	3	dimension	dimension	NOUN
gs-3960	324	4	of	of	ADP
gs-3960	324	5	mitochondrial	mitochondrial	ADJ
gs-3960	324	6	regulation	regulation	NOUN
gs-3960	324	7	suggests	suggest	VERB
gs-3960	324	8	that	that	SCONJ
gs-3960	324	9	targeting	target	VERB
gs-3960	324	10	rna	rna	NOUN
gs-3960	324	11	-	-	PUNCT
gs-3960	324	12	modifying	modify	VERB
gs-3960	324	13	enzymes	enzyme	NOUN
gs-3960	324	14	may	may	AUX
gs-3960	324	15	offer	offer	VERB
gs-3960	324	16	novel	novel	ADJ
gs-3960	324	17	therapeutic	therapeutic	ADJ
gs-3960	324	18	avenues	avenue	NOUN
gs-3960	324	19	for	for	ADP
gs-3960	324	20	restoring	restore	VERB
gs-3960	324	21	proper	proper	ADJ
gs-3960	324	22	mitochondrial	mitochondrial	ADJ
gs-3960	324	23	protein	protein	NOUN
gs-3960	324	24	synthesis	synthesis	NOUN
gs-3960	324	25	.	.	PUNCT
gs-3960	325	1	interorganelle	interorganelle	NOUN
gs-3960	325	2	stress	stress	NOUN
gs-3960	325	3	signaling	signal	VERB
gs-3960	325	4	networks	network	NOUN
gs-3960	325	5	mitochondria	mitochondria	VERB
gs-3960	325	6	in	in	ADP
gs-3960	325	7	dopaminergic	dopaminergic	ADJ
gs-3960	325	8	neurons	neuron	NOUN
gs-3960	325	9	participate	participate	VERB
gs-3960	325	10	in	in	ADP
gs-3960	325	11	elaborate	elaborate	ADJ
gs-3960	325	12	communication	communication	NOUN
gs-3960	325	13	networks	network	NOUN
gs-3960	325	14	with	with	ADP
gs-3960	325	15	other	other	ADJ
gs-3960	325	16	organelles	organelle	NOUN
gs-3960	325	17	,	,	PUNCT
gs-3960	325	18	and	and	CCONJ
gs-3960	325	19	these	these	DET
gs-3960	325	20	dialogues	dialogue	NOUN
gs-3960	325	21	are	be	AUX
gs-3960	325	22	profoundly	profoundly	ADV
gs-3960	325	23	disturbed	disturbed	ADJ
gs-3960	325	24	in	in	ADP
gs-3960	325	25	parkinson	parkinson	NOUN
gs-3960	325	26	's	's	PART
gs-3960	325	27	disease	disease	NOUN
gs-3960	325	28	.	.	PUNCT
gs-3960	326	1	recent	recent	ADJ
gs-3960	326	2	work	work	NOUN
gs-3960	326	3	has	have	AUX
gs-3960	326	4	highlighted	highlight	VERB
gs-3960	326	5	a	a	DET
gs-3960	326	6	mitochondria	mitochondria	NOUN
gs-3960	326	7	-	-	PUNCT
gs-3960	326	8	lysosome	lysosome	NOUN
gs-3960	326	9	signaling	signal	VERB
gs-3960	326	10	axis	axis	NOUN
gs-3960	326	11	where	where	SCONJ
gs-3960	326	12	mitochondrial	mitochondrial	ADJ
gs-3960	326	13	stress	stress	NOUN
gs-3960	326	14	triggers	trigger	VERB
gs-3960	326	15	lysosomal	lysosomal	ADJ
gs-3960	326	16	adaptation	adaptation	NOUN
gs-3960	326	17	through	through	ADP
gs-3960	326	18	a	a	DET
gs-3960	326	19	series	series	NOUN
gs-3960	326	20	of	of	ADP
gs-3960	326	21	calciumgeorgian	calciumgeorgian	ADJ
gs-3960	326	22	scientists/	scientists/	NUM
gs-3960	326	23	.	.	PUNCT
gs-3960	327	1	7	7	NUM
gs-3960	327	2	n	n	PRON
gs-3960	327	3	3	3	NUM
gs-3960	327	4	,	,	PUNCT
gs-3960	327	5	2025	2025	NUM
gs-3960	327	6	418	418	NUM
gs-3960	327	7	dependent	dependent	ADJ
gs-3960	327	8	signaling	signal	VERB
gs-3960	327	9	events	event	NOUN
gs-3960	327	10	.	.	PUNCT
gs-3960	328	1	in	in	ADP
gs-3960	328	2	parkinson	parkinson	NOUN
gs-3960	328	3	's	's	PART
gs-3960	328	4	neurons	neuron	NOUN
gs-3960	328	5	,	,	PUNCT
gs-3960	328	6	this	this	DET
gs-3960	328	7	communication	communication	NOUN
gs-3960	328	8	breaks	break	VERB
gs-3960	328	9	down	down	ADP
gs-3960	328	10	,	,	PUNCT
gs-3960	328	11	leading	lead	VERB
gs-3960	328	12	to	to	ADP
gs-3960	328	13	uncoordinated	uncoordinated	ADJ
gs-3960	328	14	responses	response	NOUN
gs-3960	328	15	to	to	ADP
gs-3960	328	16	cellular	cellular	ADJ
gs-3960	328	17	stress	stress	NOUN
gs-3960	328	18	.	.	PUNCT
gs-3960	329	1	particularly	particularly	ADV
gs-3960	329	2	fascinating	fascinating	ADJ
gs-3960	329	3	is	be	AUX
gs-3960	329	4	the	the	DET
gs-3960	329	5	discovery	discovery	NOUN
gs-3960	329	6	that	that	PRON
gs-3960	329	7	mitochondria	mitochondria	NOUN
gs-3960	329	8	-	-	PUNCT
gs-3960	329	9	derived	derive	VERB
gs-3960	329	10	vesicles	vesicle	NOUN
gs-3960	329	11	carry	carry	VERB
gs-3960	329	12	specific	specific	ADJ
gs-3960	329	13	signaling	signal	VERB
gs-3960	329	14	cargo	cargo	NOUN
gs-3960	329	15	to	to	PART
gs-3960	329	16	peroxisomes	peroxisome	NOUN
gs-3960	329	17	,	,	PUNCT
gs-3960	329	18	modulating	modulate	VERB
gs-3960	329	19	their	their	PRON
gs-3960	329	20	oxidative	oxidative	ADJ
gs-3960	329	21	capacity	capacity	NOUN
gs-3960	329	22	.	.	PUNCT
gs-3960	330	1	this	this	DET
gs-3960	330	2	pathway	pathway	NOUN
gs-3960	330	3	appears	appear	VERB
gs-3960	330	4	crucial	crucial	ADJ
gs-3960	330	5	for	for	ADP
gs-3960	330	6	maintaining	maintain	VERB
gs-3960	330	7	redox	redox	NOUN
gs-3960	330	8	balance	balance	NOUN
gs-3960	330	9	in	in	ADP
gs-3960	330	10	neurons	neuron	NOUN
gs-3960	330	11	with	with	ADP
gs-3960	330	12	high	high	ADJ
gs-3960	330	13	metabolic	metabolic	NOUN
gs-3960	330	14	rates	rate	NOUN
gs-3960	330	15	,	,	PUNCT
gs-3960	330	16	and	and	CCONJ
gs-3960	330	17	its	its	PRON
gs-3960	330	18	disruption	disruption	NOUN
gs-3960	330	19	may	may	AUX
gs-3960	330	20	contribute	contribute	VERB
gs-3960	330	21	to	to	ADP
gs-3960	330	22	the	the	DET
gs-3960	330	23	observed	observe	VERB
gs-3960	330	24	oxidative	oxidative	ADJ
gs-3960	330	25	stress	stress	NOUN
gs-3960	330	26	in	in	ADP
gs-3960	330	27	parkinson	parkinson	NOUN
gs-3960	330	28	's	's	PART
gs-3960	330	29	.	.	PUNCT
gs-3960	331	1	the	the	DET
gs-3960	331	2	complexity	complexity	NOUN
gs-3960	331	3	of	of	ADP
gs-3960	331	4	these	these	DET
gs-3960	331	5	interorganelle	interorganelle	ADJ
gs-3960	331	6	conversations	conversation	NOUN
gs-3960	331	7	suggests	suggest	VERB
gs-3960	331	8	that	that	SCONJ
gs-3960	331	9	therapeutic	therapeutic	ADJ
gs-3960	331	10	strategies	strategy	NOUN
gs-3960	331	11	may	may	AUX
gs-3960	331	12	need	need	VERB
gs-3960	331	13	to	to	PART
gs-3960	331	14	consider	consider	VERB
gs-3960	331	15	entire	entire	ADJ
gs-3960	331	16	cellular	cellular	ADJ
gs-3960	331	17	ecosystems	ecosystem	NOUN
gs-3960	331	18	rather	rather	ADV
gs-3960	331	19	than	than	ADP
gs-3960	331	20	targeting	target	VERB
gs-3960	331	21	mitochondria	mitochondria	NOUN
gs-3960	331	22	in	in	ADP
gs-3960	331	23	isolation	isolation	NOUN
gs-3960	331	24	.	.	PUNCT
gs-3960	332	1	activity	activity	NOUN
gs-3960	332	2	-	-	PUNCT
gs-3960	332	3	dependent	dependent	ADJ
gs-3960	332	4	mitochondrial	mitochondrial	ADJ
gs-3960	332	5	plasticity	plasticity	NOUN
gs-3960	332	6	dopaminergic	dopaminergic	ADJ
gs-3960	332	7	neurons	neuron	NOUN
gs-3960	332	8	exhibit	exhibit	VERB
gs-3960	332	9	remarkable	remarkable	ADJ
gs-3960	332	10	activity	activity	NOUN
gs-3960	332	11	-	-	PUNCT
gs-3960	332	12	dependent	dependent	ADJ
gs-3960	332	13	changes	change	NOUN
gs-3960	332	14	in	in	ADP
gs-3960	332	15	mitochondrial	mitochondrial	ADJ
gs-3960	332	16	configuration	configuration	NOUN
gs-3960	332	17	and	and	CCONJ
gs-3960	332	18	function	function	NOUN
gs-3960	332	19	,	,	PUNCT
gs-3960	332	20	a	a	DET
gs-3960	332	21	form	form	NOUN
gs-3960	332	22	of	of	ADP
gs-3960	332	23	plasticity	plasticity	NOUN
gs-3960	332	24	that	that	PRON
gs-3960	332	25	appears	appear	VERB
gs-3960	332	26	impaired	impair	VERB
gs-3960	332	27	in	in	ADP
gs-3960	332	28	parkinson	parkinson	NOUN
gs-3960	332	29	's	's	PART
gs-3960	332	30	disease	disease	NOUN
gs-3960	332	31	.	.	PUNCT
gs-3960	333	1	single	single	ADJ
gs-3960	333	2	-	-	PUNCT
gs-3960	333	3	neuron	neuron	NOUN
gs-3960	333	4	electrophysiology	electrophysiology	NOUN
gs-3960	333	5	combined	combine	VERB
gs-3960	333	6	with	with	ADP
gs-3960	333	7	mitochondrial	mitochondrial	ADJ
gs-3960	333	8	imaging	imaging	NOUN
gs-3960	333	9	reveals	reveal	VERB
gs-3960	333	10	that	that	SCONJ
gs-3960	333	11	healthy	healthy	ADJ
gs-3960	333	12	nigral	nigral	ADJ
gs-3960	333	13	neurons	neuron	NOUN
gs-3960	333	14	rapidly	rapidly	ADV
gs-3960	333	15	redistribute	redistribute	VERB
gs-3960	333	16	mitochondria	mitochondria	NOUN
gs-3960	333	17	to	to	ADP
gs-3960	333	18	active	active	ADJ
gs-3960	333	19	synaptic	synaptic	ADJ
gs-3960	333	20	sites	site	NOUN
gs-3960	333	21	during	during	ADP
gs-3960	333	22	burst	burst	ADJ
gs-3960	333	23	firing	firing	NOUN
gs-3960	333	24	,	,	PUNCT
gs-3960	333	25	while	while	SCONJ
gs-3960	333	26	parkinson	parkinson	NOUN
gs-3960	333	27	's	's	PART
gs-3960	333	28	neurons	neuron	NOUN
gs-3960	333	29	fail	fail	VERB
gs-3960	333	30	to	to	PART
gs-3960	333	31	mount	mount	VERB
gs-3960	333	32	this	this	DET
gs-3960	333	33	adaptive	adaptive	ADJ
gs-3960	333	34	response	response	NOUN
gs-3960	333	35	.	.	PUNCT
gs-3960	334	1	this	this	DET
gs-3960	334	2	deficiency	deficiency	NOUN
gs-3960	334	3	stems	stem	VERB
gs-3960	334	4	from	from	ADP
gs-3960	334	5	multiple	multiple	ADJ
gs-3960	334	6	factors	factor	NOUN
gs-3960	334	7	including	include	VERB
gs-3960	334	8	disrupted	disrupt	VERB
gs-3960	334	9	mitochondrial	mitochondrial	ADJ
gs-3960	334	10	motility	motility	NOUN
gs-3960	334	11	,	,	PUNCT
gs-3960	334	12	impaired	impaired	ADJ
gs-3960	334	13	calcium	calcium	NOUN
gs-3960	334	14	signaling	signal	VERB
gs-3960	334	15	,	,	PUNCT
gs-3960	334	16	and	and	CCONJ
gs-3960	334	17	faulty	faulty	ADJ
gs-3960	334	18	activity	activity	NOUN
gs-3960	334	19	-	-	PUNCT
gs-3960	334	20	sensing	sense	VERB
gs-3960	334	21	mechanisms	mechanism	NOUN
gs-3960	334	22	.	.	PUNCT
gs-3960	335	1	the	the	DET
gs-3960	335	2	consequence	consequence	NOUN
gs-3960	335	3	is	be	AUX
gs-3960	335	4	an	an	DET
gs-3960	335	5	inability	inability	NOUN
gs-3960	335	6	to	to	PART
gs-3960	335	7	meet	meet	VERB
gs-3960	335	8	localized	localized	ADJ
gs-3960	335	9	energy	energy	NOUN
gs-3960	335	10	demands	demand	NOUN
gs-3960	335	11	during	during	ADP
gs-3960	335	12	periods	period	NOUN
gs-3960	335	13	of	of	ADP
gs-3960	335	14	high	high	ADJ
gs-3960	335	15	neuronal	neuronal	ADJ
gs-3960	335	16	activity	activity	NOUN
gs-3960	335	17	,	,	PUNCT
gs-3960	335	18	potentially	potentially	ADV
gs-3960	335	19	explaining	explain	VERB
gs-3960	335	20	why	why	SCONJ
gs-3960	335	21	these	these	DET
gs-3960	335	22	neurons	neuron	NOUN
gs-3960	335	23	are	be	AUX
gs-3960	335	24	particularly	particularly	ADV
gs-3960	335	25	vulnerable	vulnerable	ADJ
gs-3960	335	26	to	to	ADP
gs-3960	335	27	parkinson	parkinson	NOUN
gs-3960	335	28	's	's	PART
gs-3960	335	29	pathology	pathology	NOUN
gs-3960	335	30	.	.	PUNCT
gs-3960	336	1	therapeutic	therapeutic	ADJ
gs-3960	336	2	approaches	approach	NOUN
gs-3960	336	3	that	that	PRON
gs-3960	336	4	enhance	enhance	VERB
gs-3960	336	5	mitochondrial	mitochondrial	ADJ
gs-3960	336	6	plasticity	plasticity	NOUN
gs-3960	336	7	,	,	PUNCT
gs-3960	336	8	perhaps	perhaps	ADV
gs-3960	336	9	through	through	ADP
gs-3960	336	10	modulation	modulation	NOUN
gs-3960	336	11	of	of	ADP
gs-3960	336	12	activity	activity	NOUN
gs-3960	336	13	-	-	PUNCT
gs-3960	336	14	dependent	dependent	ADJ
gs-3960	336	15	signaling	signal	VERB
gs-3960	336	16	pathways	pathway	NOUN
gs-3960	336	17	,	,	PUNCT
gs-3960	336	18	may	may	AUX
gs-3960	336	19	help	help	VERB
gs-3960	336	20	compensate	compensate	VERB
gs-3960	336	21	for	for	ADP
gs-3960	336	22	this	this	DET
gs-3960	336	23	deficit	deficit	NOUN
gs-3960	336	24	.	.	PUNCT
gs-3960	337	1	mitochondrial	mitochondrial	ADJ
gs-3960	337	2	dark	dark	ADJ
gs-3960	337	3	matter	matter	NOUN
gs-3960	337	4	:	:	PUNCT
gs-3960	337	5	the	the	DET
gs-3960	337	6	unexplored	unexplored	ADJ
gs-3960	337	7	proteome	proteome	NOUN
gs-3960	337	8	while	while	SCONJ
gs-3960	337	9	much	much	ADJ
gs-3960	337	10	attention	attention	NOUN
gs-3960	337	11	has	have	AUX
gs-3960	337	12	focused	focus	VERB
gs-3960	337	13	on	on	ADP
gs-3960	337	14	known	know	VERB
gs-3960	337	15	mitochondrial	mitochondrial	ADJ
gs-3960	337	16	proteins	protein	NOUN
gs-3960	337	17	,	,	PUNCT
gs-3960	337	18	recent	recent	ADJ
gs-3960	337	19	proteomic	proteomic	ADJ
gs-3960	337	20	studies	study	NOUN
gs-3960	337	21	suggest	suggest	VERB
gs-3960	337	22	we	we	PRON
gs-3960	337	23	have	have	AUX
gs-3960	337	24	barely	barely	ADV
gs-3960	337	25	scratched	scratch	VERB
gs-3960	337	26	the	the	DET
gs-3960	337	27	surface	surface	NOUN
gs-3960	337	28	of	of	ADP
gs-3960	337	29	the	the	DET
gs-3960	337	30	mitochondrial	mitochondrial	ADJ
gs-3960	337	31	proteome	proteome	NOUN
gs-3960	337	32	.	.	PUNCT
gs-3960	338	1	mass	mass	PROPN
gs-3960	338	2	spectrometry	spectrometry	NOUN
gs-3960	338	3	analyses	analysis	NOUN
gs-3960	338	4	have	have	AUX
gs-3960	338	5	identified	identify	VERB
gs-3960	338	6	hundreds	hundred	NOUN
gs-3960	338	7	of	of	ADP
gs-3960	338	8	previously	previously	ADV
gs-3960	338	9	unannotated	unannotate	VERB
gs-3960	338	10	mitochondrial	mitochondrial	ADJ
gs-3960	338	11	proteins	protein	NOUN
gs-3960	338	12	,	,	PUNCT
gs-3960	338	13	many	many	ADJ
gs-3960	338	14	of	of	ADP
gs-3960	338	15	which	which	PRON
gs-3960	338	16	show	show	VERB
gs-3960	338	17	differential	differential	ADJ
gs-3960	338	18	expression	expression	NOUN
gs-3960	338	19	in	in	ADP
gs-3960	338	20	parkinson	parkinson	NOUN
gs-3960	338	21	's	's	PART
gs-3960	338	22	disease	disease	NOUN
gs-3960	338	23	.	.	PUNCT
gs-3960	339	1	among	among	ADP
gs-3960	339	2	these	these	PRON
gs-3960	339	3	are	be	AUX
gs-3960	339	4	novel	novel	ADJ
gs-3960	339	5	assembly	assembly	NOUN
gs-3960	339	6	factors	factor	NOUN
gs-3960	339	7	for	for	ADP
gs-3960	339	8	respiratory	respiratory	ADJ
gs-3960	339	9	complexes	complex	NOUN
gs-3960	339	10	,	,	PUNCT
gs-3960	339	11	uncharacterized	uncharacterized	ADJ
gs-3960	339	12	regulators	regulator	NOUN
gs-3960	339	13	of	of	ADP
gs-3960	339	14	mitochondrial	mitochondrial	ADJ
gs-3960	339	15	dynamics	dynamic	NOUN
gs-3960	339	16	,	,	PUNCT
gs-3960	339	17	and	and	CCONJ
gs-3960	339	18	entirely	entirely	ADV
gs-3960	339	19	new	new	ADJ
gs-3960	339	20	classes	class	NOUN
gs-3960	339	21	of	of	ADP
gs-3960	339	22	mitochondrial	mitochondrial	ADJ
gs-3960	339	23	signaling	signal	VERB
gs-3960	339	24	molecules	molecule	NOUN
gs-3960	339	25	.	.	PUNCT
gs-3960	340	1	particularly	particularly	ADV
gs-3960	340	2	intriguing	intriguing	ADJ
gs-3960	340	3	is	be	AUX
gs-3960	340	4	the	the	DET
gs-3960	340	5	discovery	discovery	NOUN
gs-3960	340	6	of	of	ADP
gs-3960	340	7	a	a	DET
gs-3960	340	8	family	family	NOUN
gs-3960	340	9	of	of	ADP
gs-3960	340	10	small	small	ADJ
gs-3960	340	11	mitochondrial	mitochondrial	ADJ
gs-3960	340	12	-	-	PUNCT
gs-3960	340	13	derived	derive	VERB
gs-3960	340	14	peptides	peptide	NOUN
gs-3960	340	15	that	that	PRON
gs-3960	340	16	appear	appear	VERB
gs-3960	340	17	to	to	PART
gs-3960	340	18	function	function	VERB
gs-3960	340	19	as	as	ADP
gs-3960	340	20	neuromodulators	neuromodulator	NOUN
gs-3960	340	21	.	.	PUNCT
gs-3960	341	1	some	some	PRON
gs-3960	341	2	of	of	ADP
gs-3960	341	3	these	these	DET
gs-3960	341	4	peptides	peptide	NOUN
gs-3960	341	5	are	be	AUX
gs-3960	341	6	selectively	selectively	ADV
gs-3960	341	7	expressed	express	VERB
gs-3960	341	8	in	in	ADP
gs-3960	341	9	dopaminergic	dopaminergic	ADJ
gs-3960	341	10	neurons	neuron	NOUN
gs-3960	341	11	and	and	CCONJ
gs-3960	341	12	show	show	VERB
gs-3960	341	13	altered	alter	VERB
gs-3960	341	14	levels	level	NOUN
gs-3960	341	15	in	in	ADP
gs-3960	341	16	parkinson	parkinson	NOUN
gs-3960	341	17	's	's	PART
gs-3960	341	18	patients	patient	NOUN
gs-3960	341	19	.	.	PUNCT
gs-3960	342	1	the	the	DET
gs-3960	342	2	functions	function	NOUN
gs-3960	342	3	of	of	ADP
gs-3960	342	4	these	these	DET
gs-3960	342	5	peptides	peptide	NOUN
gs-3960	342	6	remain	remain	VERB
gs-3960	342	7	largely	largely	ADV
gs-3960	342	8	mysterious	mysterious	ADJ
gs-3960	342	9	,	,	PUNCT
gs-3960	342	10	but	but	CCONJ
gs-3960	342	11	preliminary	preliminary	ADJ
gs-3960	342	12	evidence	evidence	NOUN
gs-3960	342	13	suggests	suggest	VERB
gs-3960	342	14	they	they	PRON
gs-3960	342	15	may	may	AUX
gs-3960	342	16	participate	participate	VERB
gs-3960	342	17	in	in	ADP
gs-3960	342	18	activity	activity	NOUN
gs-3960	342	19	-	-	PUNCT
gs-3960	342	20	dependent	dependent	ADJ
gs-3960	342	21	feedback	feedback	NOUN
gs-3960	342	22	loops	loop	NOUN
gs-3960	342	23	between	between	ADP
gs-3960	342	24	mitochondrial	mitochondrial	ADJ
gs-3960	342	25	function	function	NOUN
gs-3960	342	26	and	and	CCONJ
gs-3960	342	27	neuronal	neuronal	ADJ
gs-3960	342	28	excitability	excitability	NOUN
gs-3960	343	1	[	[	X
gs-3960	343	2	75,76,79	75,76,79	NUM
gs-3960	343	3	]	]	PUNCT
gs-3960	343	4	.	.	PUNCT
gs-3960	344	1	georgian	georgian	NOUN
gs-3960	344	2	scientists/	scientists/	NUM
gs-3960	344	3	.	.	PUNCT
gs-3960	345	1	7	7	NUM
gs-3960	345	2	n	n	PRON
gs-3960	345	3	3	3	NUM
gs-3960	345	4	,	,	PUNCT
gs-3960	345	5	2025	2025	NUM
gs-3960	345	6	419	419	NUM
gs-3960	345	7	environmental	environmental	ADJ
gs-3960	345	8	mitochondrial	mitochondrial	ADJ
gs-3960	345	9	toxins	toxin	NOUN
gs-3960	345	10	revisited	revisit	VERB
gs-3960	345	11	the	the	DET
gs-3960	345	12	historical	historical	ADJ
gs-3960	345	13	link	link	NOUN
gs-3960	345	14	between	between	ADP
gs-3960	345	15	mitochondrial	mitochondrial	ADJ
gs-3960	345	16	toxins	toxin	NOUN
gs-3960	345	17	and	and	CCONJ
gs-3960	345	18	parkinsonism	parkinsonism	NOUN
gs-3960	345	19	has	have	AUX
gs-3960	345	20	taken	take	VERB
gs-3960	345	21	on	on	ADP
gs-3960	345	22	new	new	ADJ
gs-3960	345	23	dimensions	dimension	NOUN
gs-3960	345	24	with	with	ADP
gs-3960	345	25	the	the	DET
gs-3960	345	26	identification	identification	NOUN
gs-3960	345	27	of	of	ADP
gs-3960	345	28	previously	previously	ADV
gs-3960	345	29	unrecognized	unrecognize	VERB
gs-3960	345	30	environmental	environmental	ADJ
gs-3960	345	31	triggers	trigger	NOUN
gs-3960	345	32	.	.	PUNCT
gs-3960	346	1	modern	modern	ADJ
gs-3960	346	2	analytical	analytical	ADJ
gs-3960	346	3	chemistry	chemistry	NOUN
gs-3960	346	4	techniques	technique	NOUN
gs-3960	346	5	have	have	AUX
gs-3960	346	6	detected	detect	VERB
gs-3960	346	7	novel	novel	ADJ
gs-3960	346	8	classes	class	NOUN
gs-3960	346	9	of	of	ADP
gs-3960	346	10	mitochondrial	mitochondrial	ADJ
gs-3960	346	11	complex	complex	NOUN
gs-3960	346	12	i	i	PRON
gs-3960	346	13	inhibitors	inhibitor	NOUN
gs-3960	346	14	in	in	ADP
gs-3960	346	15	urban	urban	ADJ
gs-3960	346	16	air	air	NOUN
gs-3960	346	17	pollution	pollution	NOUN
gs-3960	346	18	samples	sample	NOUN
gs-3960	346	19	,	,	PUNCT
gs-3960	346	20	some	some	PRON
gs-3960	346	21	of	of	ADP
gs-3960	346	22	which	which	PRON
gs-3960	346	23	show	show	VERB
gs-3960	346	24	selective	selective	ADJ
gs-3960	346	25	toxicity	toxicity	NOUN
gs-3960	346	26	toward	toward	ADP
gs-3960	346	27	dopaminergic	dopaminergic	ADJ
gs-3960	346	28	neurons	neuron	NOUN
gs-3960	346	29	at	at	ADP
gs-3960	346	30	concentrations	concentration	NOUN
gs-3960	346	31	previously	previously	ADV
gs-3960	346	32	considered	consider	VERB
gs-3960	346	33	safe	safe	ADJ
gs-3960	346	34	.	.	PUNCT
gs-3960	347	1	simultaneously	simultaneously	ADV
gs-3960	347	2	,	,	PUNCT
gs-3960	347	3	the	the	DET
gs-3960	347	4	microbiome	microbiome	NOUN
gs-3960	347	5	has	have	AUX
gs-3960	347	6	emerged	emerge	VERB
gs-3960	347	7	as	as	ADP
gs-3960	347	8	a	a	DET
gs-3960	347	9	source	source	NOUN
gs-3960	347	10	of	of	ADP
gs-3960	347	11	endogenous	endogenous	ADJ
gs-3960	347	12	mitochondrial	mitochondrial	ADJ
gs-3960	347	13	-	-	PUNCT
gs-3960	347	14	modulating	modulate	VERB
gs-3960	347	15	compounds	compound	NOUN
gs-3960	347	16	.	.	PUNCT
gs-3960	348	1	certain	certain	ADJ
gs-3960	348	2	gut	gut	NOUN
gs-3960	348	3	bacteria	bacteria	NOUN
gs-3960	348	4	produce	produce	VERB
gs-3960	348	5	metabolites	metabolite	NOUN
gs-3960	348	6	that	that	PRON
gs-3960	348	7	can	can	AUX
gs-3960	348	8	either	either	CCONJ
gs-3960	348	9	protect	protect	VERB
gs-3960	348	10	or	or	CCONJ
gs-3960	348	11	impair	impair	VERB
gs-3960	348	12	mitochondrial	mitochondrial	ADJ
gs-3960	348	13	function	function	NOUN
gs-3960	348	14	,	,	PUNCT
gs-3960	348	15	and	and	CCONJ
gs-3960	348	16	the	the	DET
gs-3960	348	17	balance	balance	NOUN
gs-3960	348	18	of	of	ADP
gs-3960	348	19	these	these	DET
gs-3960	348	20	microbial	microbial	ADJ
gs-3960	348	21	communities	community	NOUN
gs-3960	348	22	appears	appear	VERB
gs-3960	348	23	altered	alter	VERB
gs-3960	348	24	in	in	ADP
gs-3960	348	25	parkinson	parkinson	NOUN
gs-3960	348	26	's	's	PART
gs-3960	348	27	patients	patient	NOUN
gs-3960	348	28	.	.	PUNCT
gs-3960	349	1	this	this	PRON
gs-3960	349	2	raises	raise	VERB
gs-3960	349	3	the	the	DET
gs-3960	349	4	possibility	possibility	NOUN
gs-3960	349	5	that	that	SCONJ
gs-3960	349	6	some	some	DET
gs-3960	349	7	cases	case	NOUN
gs-3960	349	8	of	of	ADP
gs-3960	349	9	parkinson	parkinson	NOUN
gs-3960	349	10	's	's	PART
gs-3960	349	11	may	may	AUX
gs-3960	349	12	stem	stem	VERB
gs-3960	349	13	from	from	ADP
gs-3960	349	14	chronic	chronic	ADJ
gs-3960	349	15	,	,	PUNCT
gs-3960	349	16	low	low	ADJ
gs-3960	349	17	-	-	PUNCT
gs-3960	349	18	level	level	NOUN
gs-3960	349	19	mitochondrial	mitochondrial	ADJ
gs-3960	349	20	poisoning	poisoning	NOUN
gs-3960	349	21	from	from	ADP
gs-3960	349	22	environmental	environmental	ADJ
gs-3960	349	23	or	or	CCONJ
gs-3960	349	24	endogenous	endogenous	ADJ
gs-3960	349	25	sources	source	NOUN
gs-3960	349	26	acting	act	VERB
gs-3960	349	27	over	over	ADP
gs-3960	349	28	decades	decade	NOUN
gs-3960	349	29	.	.	PUNCT
gs-3960	350	1	the	the	DET
gs-3960	350	2	mitochondrial	mitochondrial	ADJ
gs-3960	350	3	clock	clock	NOUN
gs-3960	350	4	and	and	CCONJ
gs-3960	350	5	neuronal	neuronal	ADJ
gs-3960	350	6	aging	aging	NOUN
gs-3960	350	7	the	the	DET
gs-3960	350	8	intersection	intersection	NOUN
gs-3960	350	9	between	between	ADP
gs-3960	350	10	mitochondrial	mitochondrial	ADJ
gs-3960	350	11	dysfunction	dysfunction	NOUN
gs-3960	350	12	and	and	CCONJ
gs-3960	350	13	biological	biological	ADJ
gs-3960	350	14	aging	aging	NOUN
gs-3960	350	15	has	have	AUX
gs-3960	350	16	become	become	VERB
gs-3960	350	17	increasingly	increasingly	ADV
gs-3960	350	18	apparent	apparent	ADJ
gs-3960	350	19	in	in	ADP
gs-3960	350	20	parkinson	parkinson	NOUN
gs-3960	350	21	's	's	PART
gs-3960	350	22	research	research	NOUN
gs-3960	350	23	.	.	PUNCT
gs-3960	351	1	mitochondria	mitochondria	PROPN
gs-3960	351	2	appear	appear	VERB
gs-3960	351	3	to	to	PART
gs-3960	351	4	harbor	harbor	VERB
gs-3960	351	5	their	their	PRON
gs-3960	351	6	own	own	ADJ
gs-3960	351	7	molecular	molecular	ADJ
gs-3960	351	8	clock	clock	NOUN
gs-3960	351	9	mechanisms	mechanism	NOUN
gs-3960	351	10	that	that	PRON
gs-3960	351	11	track	track	VERB
gs-3960	351	12	cellular	cellular	ADJ
gs-3960	351	13	age	age	NOUN
gs-3960	351	14	independently	independently	ADV
gs-3960	351	15	of	of	ADP
gs-3960	351	16	the	the	DET
gs-3960	351	17	nuclear	nuclear	ADJ
gs-3960	351	18	genome	genome	NOUN
gs-3960	351	19	.	.	PUNCT
gs-3960	352	1	this	this	DET
gs-3960	352	2	mitochondrial	mitochondrial	ADJ
gs-3960	352	3	clock	clock	NOUN
gs-3960	352	4	accelerates	accelerate	VERB
gs-3960	352	5	in	in	ADP
gs-3960	352	6	parkinson	parkinson	NOUN
gs-3960	352	7	's	's	PART
gs-3960	352	8	disease	disease	NOUN
gs-3960	352	9	,	,	PUNCT
gs-3960	352	10	as	as	SCONJ
gs-3960	352	11	evidenced	evidence	VERB
gs-3960	352	12	by	by	ADP
gs-3960	352	13	specific	specific	ADJ
gs-3960	352	14	epigenetic	epigenetic	ADJ
gs-3960	352	15	changes	change	NOUN
gs-3960	352	16	to	to	ADP
gs-3960	352	17	mitochondrial	mitochondrial	ADJ
gs-3960	352	18	dna	dna	NOUN
gs-3960	352	19	and	and	CCONJ
gs-3960	352	20	progressive	progressive	ADJ
gs-3960	352	21	alterations	alteration	NOUN
gs-3960	352	22	in	in	ADP
gs-3960	352	23	mitochondrial	mitochondrial	ADJ
gs-3960	352	24	protein	protein	NOUN
gs-3960	352	25	turnover	turnover	NOUN
gs-3960	352	26	rates	rate	NOUN
gs-3960	352	27	.	.	PUNCT
gs-3960	353	1	remarkably	remarkably	ADV
gs-3960	353	2	,	,	PUNCT
gs-3960	353	3	certain	certain	ADJ
gs-3960	353	4	aspects	aspect	NOUN
gs-3960	353	5	of	of	ADP
gs-3960	353	6	this	this	DET
gs-3960	353	7	accelerated	accelerate	VERB
gs-3960	353	8	aging	aging	NOUN
gs-3960	353	9	appear	appear	VERB
gs-3960	353	10	reversible	reversible	ADJ
gs-3960	353	11	in	in	ADP
gs-3960	353	12	experimental	experimental	ADJ
gs-3960	353	13	models	model	NOUN
gs-3960	353	14	.	.	PUNCT
gs-3960	354	1	interventions	intervention	NOUN
gs-3960	354	2	that	that	PRON
gs-3960	354	3	target	target	VERB
gs-3960	354	4	mitochondrial	mitochondrial	ADJ
gs-3960	354	5	protein	protein	NOUN
gs-3960	354	6	quality	quality	NOUN
gs-3960	354	7	control	control	NOUN
gs-3960	354	8	systems	system	NOUN
gs-3960	354	9	can	can	AUX
gs-3960	354	10	effectively	effectively	ADV
gs-3960	354	11	"	"	PUNCT
gs-3960	354	12	reset	reset	VERB
gs-3960	354	13	"	"	PUNCT
gs-3960	354	14	aspects	aspect	NOUN
gs-3960	354	15	of	of	ADP
gs-3960	354	16	the	the	DET
gs-3960	354	17	mitochondrial	mitochondrial	ADJ
gs-3960	354	18	clock	clock	NOUN
gs-3960	354	19	,	,	PUNCT
gs-3960	354	20	restoring	restore	VERB
gs-3960	354	21	more	more	ADV
gs-3960	354	22	youthful	youthful	ADJ
gs-3960	354	23	patterns	pattern	NOUN
gs-3960	354	24	of	of	ADP
gs-3960	354	25	mitochondrial	mitochondrial	ADJ
gs-3960	354	26	function	function	NOUN
gs-3960	354	27	.	.	PUNCT
gs-3960	355	1	this	this	PRON
gs-3960	355	2	suggests	suggest	VERB
gs-3960	355	3	that	that	SCONJ
gs-3960	355	4	parkinson	parkinson	NOUN
gs-3960	355	5	's	's	PART
gs-3960	355	6	disease	disease	NOUN
gs-3960	355	7	may	may	AUX
gs-3960	355	8	involve	involve	VERB
gs-3960	355	9	not	not	PART
gs-3960	355	10	just	just	ADV
gs-3960	355	11	mitochondrial	mitochondrial	ADJ
gs-3960	355	12	damage	damage	NOUN
gs-3960	355	13	but	but	CCONJ
gs-3960	355	14	a	a	DET
gs-3960	355	15	fundamental	fundamental	ADJ
gs-3960	355	16	dysregulation	dysregulation	NOUN
gs-3960	355	17	of	of	ADP
gs-3960	355	18	mitochondrial	mitochondrial	ADJ
gs-3960	355	19	aging	age	VERB
gs-3960	355	20	processes	process	NOUN
gs-3960	355	21	,	,	PUNCT
gs-3960	355	22	opening	open	VERB
gs-3960	355	23	new	new	ADJ
gs-3960	355	24	avenues	avenue	NOUN
gs-3960	355	25	for	for	ADP
gs-3960	355	26	therapeutic	therapeutic	ADJ
gs-3960	355	27	intervention	intervention	NOUN
gs-3960	355	28	.	.	PUNCT
gs-3960	356	1	neuronal	neuronal	ADJ
gs-3960	356	2	subtype	subtype	NOUN
gs-3960	356	3	-	-	PUNCT
gs-3960	356	4	specific	specific	ADJ
gs-3960	356	5	mitochondrial	mitochondrial	ADJ
gs-3960	356	6	programs	program	NOUN
gs-3960	356	7	single	single	ADJ
gs-3960	356	8	-	-	PUNCT
gs-3960	356	9	cell	cell	NOUN
gs-3960	356	10	sequencing	sequence	VERB
gs-3960	356	11	technologies	technology	NOUN
gs-3960	356	12	have	have	AUX
gs-3960	356	13	revealed	reveal	VERB
gs-3960	356	14	that	that	SCONJ
gs-3960	356	15	not	not	PART
gs-3960	356	16	all	all	DET
gs-3960	356	17	dopaminergic	dopaminergic	ADJ
gs-3960	356	18	neurons	neuron	NOUN
gs-3960	356	19	are	be	AUX
gs-3960	356	20	equally	equally	ADV
gs-3960	356	21	vulnerable	vulnerable	ADJ
gs-3960	356	22	in	in	ADP
gs-3960	356	23	parkinson	parkinson	NOUN
gs-3960	356	24	's	's	PART
gs-3960	356	25	disease	disease	NOUN
gs-3960	356	26	,	,	PUNCT
gs-3960	356	27	and	and	CCONJ
gs-3960	356	28	these	these	DET
gs-3960	356	29	differences	difference	NOUN
gs-3960	356	30	correlate	correlate	VERB
gs-3960	356	31	with	with	ADP
gs-3960	356	32	distinct	distinct	ADJ
gs-3960	356	33	mitochondrial	mitochondrial	ADJ
gs-3960	356	34	gene	gene	NOUN
gs-3960	356	35	expression	expression	NOUN
gs-3960	356	36	programs	program	NOUN
gs-3960	356	37	.	.	PUNCT
gs-3960	357	1	particularly	particularly	ADV
gs-3960	357	2	resistant	resistant	ADJ
gs-3960	357	3	subpopulations	subpopulation	NOUN
gs-3960	357	4	of	of	ADP
gs-3960	357	5	nigral	nigral	ADJ
gs-3960	357	6	neurons	neuron	NOUN
gs-3960	357	7	show	show	VERB
gs-3960	357	8	enhanced	enhance	VERB
gs-3960	357	9	expression	expression	NOUN
gs-3960	357	10	of	of	ADP
gs-3960	357	11	mitochondrial	mitochondrial	ADJ
gs-3960	357	12	stress	stress	NOUN
gs-3960	357	13	response	response	NOUN
gs-3960	357	14	pathways	pathway	NOUN
gs-3960	357	15	and	and	CCONJ
gs-3960	357	16	more	more	ADV
gs-3960	357	17	robust	robust	ADJ
gs-3960	357	18	mechanisms	mechanism	NOUN
gs-3960	357	19	for	for	ADP
gs-3960	357	20	maintaining	maintain	VERB
gs-3960	357	21	nad+	nad+	NOUN
gs-3960	357	22	homeostasis	homeostasis	NOUN
gs-3960	357	23	.	.	PUNCT
gs-3960	358	1	this	this	DET
gs-3960	358	2	heterogeneity	heterogeneity	NOUN
gs-3960	358	3	explains	explain	VERB
gs-3960	358	4	why	why	SCONJ
gs-3960	358	5	certain	certain	ADJ
gs-3960	358	6	dopaminergic	dopaminergic	ADJ
gs-3960	358	7	neuron	neuron	NOUN
gs-3960	358	8	populations	population	NOUN
gs-3960	358	9	survive	survive	VERB
gs-3960	358	10	for	for	ADP
gs-3960	358	11	decades	decade	NOUN
gs-3960	358	12	in	in	ADP
gs-3960	358	13	parkinson	parkinson	NOUN
gs-3960	358	14	's	's	PART
gs-3960	358	15	patients	patient	NOUN
gs-3960	358	16	while	while	SCONJ
gs-3960	358	17	others	other	NOUN
gs-3960	358	18	degenerate	degenerate	VERB
gs-3960	358	19	early	early	ADV
gs-3960	358	20	in	in	ADP
gs-3960	358	21	the	the	DET
gs-3960	358	22	disease	disease	NOUN
gs-3960	358	23	course	course	NOUN
gs-3960	358	24	.	.	PUNCT
gs-3960	359	1	understanding	understand	VERB
gs-3960	359	2	the	the	DET
gs-3960	359	3	molecular	molecular	ADJ
gs-3960	359	4	basis	basis	NOUN
gs-3960	359	5	of	of	ADP
gs-3960	359	6	this	this	DET
gs-3960	359	7	selective	selective	ADJ
gs-3960	359	8	resistance	resistance	NOUN
gs-3960	359	9	may	may	AUX
gs-3960	359	10	provide	provide	VERB
gs-3960	359	11	clues	clue	NOUN
gs-3960	359	12	for	for	ADP
gs-3960	359	13	developing	develop	VERB
gs-3960	359	14	neuroprotective	neuroprotective	ADJ
gs-3960	359	15	strategies	strategy	NOUN
gs-3960	359	16	that	that	PRON
gs-3960	359	17	can	can	AUX
gs-3960	359	18	confer	confer	VERB
gs-3960	359	19	similar	similar	ADJ
gs-3960	359	20	resilience	resilience	NOUN
gs-3960	359	21	to	to	ADP
gs-3960	359	22	vulnerable	vulnerable	ADJ
gs-3960	359	23	neurons	neuron	NOUN
gs-3960	360	1	[	[	X
gs-3960	360	2	21,81,83	21,81,83	NUM
gs-3960	360	3	]	]	PUNCT
gs-3960	360	4	.	.	PUNCT
gs-3960	361	1	georgian	georgian	PROPN
gs-3960	361	2	scientists/	scientists/	NUM
gs-3960	361	3	.	.	PUNCT
gs-3960	362	1	7	7	NUM
gs-3960	362	2	n	n	PRON
gs-3960	362	3	3	3	NUM
gs-3960	362	4	,	,	PUNCT
gs-3960	362	5	2025	2025	NUM
gs-3960	362	6	420	420	NUM
gs-3960	362	7	mitochondria	mitochondria	NOUN
gs-3960	362	8	as	as	SCONJ
gs-3960	362	9	information	information	NOUN
gs-3960	362	10	processors	processor	NOUN
gs-3960	362	11	a	a	DET
gs-3960	362	12	revolutionary	revolutionary	ADJ
gs-3960	362	13	concept	concept	NOUN
gs-3960	362	14	emerging	emerge	VERB
gs-3960	362	15	from	from	ADP
gs-3960	362	16	recent	recent	ADJ
gs-3960	362	17	research	research	NOUN
gs-3960	362	18	positions	position	NOUN
gs-3960	362	19	mitochondria	mitochondria	VERB
gs-3960	362	20	as	as	ADP
gs-3960	362	21	sophisticated	sophisticated	ADJ
gs-3960	362	22	information	information	NOUN
gs-3960	362	23	processing	processing	NOUN
gs-3960	362	24	systems	system	NOUN
gs-3960	362	25	rather	rather	ADV
gs-3960	362	26	than	than	ADP
gs-3960	362	27	mere	mere	ADJ
gs-3960	362	28	energy	energy	NOUN
gs-3960	362	29	factories	factory	NOUN
gs-3960	362	30	.	.	PUNCT
gs-3960	363	1	the	the	DET
gs-3960	363	2	mitochondrial	mitochondrial	ADJ
gs-3960	363	3	network	network	NOUN
gs-3960	363	4	appears	appear	VERB
gs-3960	363	5	capable	capable	ADJ
gs-3960	363	6	of	of	ADP
gs-3960	363	7	integrating	integrate	VERB
gs-3960	363	8	multiple	multiple	ADJ
gs-3960	363	9	metabolic	metabolic	NOUN
gs-3960	363	10	and	and	CCONJ
gs-3960	363	11	stress	stress	NOUN
gs-3960	363	12	signals	signal	NOUN
gs-3960	363	13	to	to	PART
gs-3960	363	14	generate	generate	VERB
gs-3960	363	15	coordinated	coordinated	ADJ
gs-3960	363	16	responses	response	NOUN
gs-3960	363	17	at	at	ADP
gs-3960	363	18	the	the	DET
gs-3960	363	19	whole	whole	ADJ
gs-3960	363	20	-	-	PUNCT
gs-3960	363	21	cell	cell	NOUN
gs-3960	363	22	level	level	NOUN
gs-3960	363	23	.	.	PUNCT
gs-3960	364	1	in	in	ADP
gs-3960	364	2	parkinson	parkinson	NOUN
gs-3960	364	3	's	's	PART
gs-3960	364	4	disease	disease	NOUN
gs-3960	364	5	,	,	PUNCT
gs-3960	364	6	this	this	DET
gs-3960	364	7	information	information	NOUN
gs-3960	364	8	processing	processing	NOUN
gs-3960	364	9	capacity	capacity	NOUN
gs-3960	364	10	breaks	break	VERB
gs-3960	364	11	down	down	ADP
gs-3960	364	12	,	,	PUNCT
gs-3960	364	13	leading	lead	VERB
gs-3960	364	14	to	to	ADP
gs-3960	364	15	uncoordinated	uncoordinated	ADJ
gs-3960	364	16	and	and	CCONJ
gs-3960	364	17	often	often	ADV
gs-3960	364	18	maladaptive	maladaptive	ADJ
gs-3960	364	19	responses	response	NOUN
gs-3960	364	20	to	to	ADP
gs-3960	364	21	cellular	cellular	ADJ
gs-3960	364	22	challenges	challenge	NOUN
gs-3960	364	23	.	.	PUNCT
gs-3960	365	1	this	this	DET
gs-3960	365	2	systems	system	NOUN
gs-3960	365	3	-	-	PUNCT
gs-3960	365	4	level	level	NOUN
gs-3960	365	5	understanding	understanding	NOUN
gs-3960	365	6	suggests	suggest	VERB
gs-3960	365	7	that	that	SCONJ
gs-3960	365	8	future	future	ADJ
gs-3960	365	9	therapies	therapy	NOUN
gs-3960	365	10	may	may	AUX
gs-3960	365	11	need	need	VERB
gs-3960	365	12	to	to	PART
gs-3960	365	13	target	target	VERB
gs-3960	365	14	mitochondrial	mitochondrial	ADJ
gs-3960	365	15	signaling	signal	VERB
gs-3960	365	16	networks	network	NOUN
gs-3960	365	17	rather	rather	ADV
gs-3960	365	18	than	than	ADP
gs-3960	365	19	individual	individual	ADJ
gs-3960	365	20	pathways	pathway	NOUN
gs-3960	365	21	.	.	PUNCT
gs-3960	366	1	approaches	approach	NOUN
gs-3960	366	2	that	that	PRON
gs-3960	366	3	restore	restore	VERB
gs-3960	366	4	the	the	DET
gs-3960	366	5	integrative	integrative	ADJ
gs-3960	366	6	capacity	capacity	NOUN
gs-3960	366	7	of	of	ADP
gs-3960	366	8	the	the	DET
gs-3960	366	9	mitochondrial	mitochondrial	ADJ
gs-3960	366	10	network	network	NOUN
gs-3960	366	11	,	,	PUNCT
gs-3960	366	12	perhaps	perhaps	ADV
gs-3960	366	13	through	through	ADP
gs-3960	366	14	modulation	modulation	NOUN
gs-3960	366	15	of	of	ADP
gs-3960	366	16	mitochondrial	mitochondrial	ADJ
gs-3960	366	17	calcium	calcium	NOUN
gs-3960	366	18	handling	handling	NOUN
gs-3960	366	19	or	or	CCONJ
gs-3960	366	20	redox	redox	NOUN
gs-3960	366	21	signaling	signal	VERB
gs-3960	366	22	,	,	PUNCT
gs-3960	366	23	may	may	AUX
gs-3960	366	24	prove	prove	VERB
gs-3960	366	25	more	more	ADV
gs-3960	366	26	effective	effective	ADJ
gs-3960	366	27	than	than	ADP
gs-3960	366	28	strategies	strategy	NOUN
gs-3960	366	29	targeting	target	VERB
gs-3960	366	30	single	single	ADJ
gs-3960	366	31	defective	defective	ADJ
gs-3960	366	32	enzymes	enzyme	NOUN
gs-3960	366	33	or	or	CCONJ
gs-3960	366	34	pathways	pathway	NOUN
gs-3960	366	35	.	.	PUNCT
gs-3960	367	1	therapeutic	therapeutic	ADJ
gs-3960	367	2	horizons	horizon	NOUN
gs-3960	367	3	:	:	PUNCT
gs-3960	367	4	beyond	beyond	ADP
gs-3960	367	5	energy	energy	NOUN
gs-3960	367	6	rescue	rescue	NOUN
gs-3960	367	7	the	the	DET
gs-3960	367	8	traditional	traditional	ADJ
gs-3960	367	9	view	view	NOUN
gs-3960	367	10	of	of	ADP
gs-3960	367	11	mitochondrial	mitochondrial	ADJ
gs-3960	367	12	therapy	therapy	NOUN
gs-3960	367	13	as	as	ADP
gs-3960	367	14	simply	simply	ADV
gs-3960	367	15	boosting	boost	VERB
gs-3960	367	16	atp	atp	NOUN
gs-3960	367	17	production	production	NOUN
gs-3960	367	18	is	be	AUX
gs-3960	367	19	giving	give	VERB
gs-3960	367	20	way	way	NOUN
gs-3960	367	21	to	to	ADP
gs-3960	367	22	more	more	ADV
gs-3960	367	23	nuanced	nuanced	ADJ
gs-3960	367	24	approaches	approach	NOUN
gs-3960	367	25	aimed	aim	VERB
gs-3960	367	26	at	at	ADP
gs-3960	367	27	restoring	restore	VERB
gs-3960	367	28	the	the	DET
gs-3960	367	29	multifaceted	multifaceted	ADJ
gs-3960	367	30	roles	role	NOUN
gs-3960	367	31	of	of	ADP
gs-3960	367	32	mitochondria	mitochondria	NOUN
gs-3960	367	33	in	in	ADP
gs-3960	367	34	neuronal	neuronal	ADJ
gs-3960	367	35	health	health	NOUN
gs-3960	367	36	.	.	PUNCT
gs-3960	368	1	next	next	ADJ
gs-3960	368	2	-	-	PUNCT
gs-3960	368	3	generation	generation	NOUN
gs-3960	368	4	strategies	strategy	NOUN
gs-3960	368	5	in	in	ADP
gs-3960	368	6	development	development	NOUN
gs-3960	368	7	include	include	VERB
gs-3960	368	8	:	:	PUNCT
gs-3960	368	9	compounds	compound	NOUN
gs-3960	368	10	that	that	PRON
gs-3960	368	11	selectively	selectively	ADV
gs-3960	368	12	remodel	remodel	VERB
gs-3960	368	13	mitochondrial	mitochondrial	ADJ
gs-3960	368	14	membrane	membrane	NOUN
gs-3960	368	15	lipid	lipid	NOUN
gs-3960	368	16	composition	composition	NOUN
gs-3960	368	17	to	to	PART
gs-3960	368	18	restore	restore	VERB
gs-3960	368	19	proper	proper	ADJ
gs-3960	368	20	protein	protein	NOUN
gs-3960	368	21	import	import	NOUN
gs-3960	368	22	and	and	CCONJ
gs-3960	368	23	respiratory	respiratory	ADJ
gs-3960	368	24	chain	chain	NOUN
gs-3960	368	25	organization	organization	NOUN
gs-3960	368	26	;	;	PUNCT
gs-3960	368	27	gene	gene	NOUN
gs-3960	368	28	therapy	therapy	NOUN
gs-3960	368	29	approaches	approach	VERB
gs-3960	368	30	targeting	target	VERB
gs-3960	368	31	the	the	DET
gs-3960	368	32	mitochondrial	mitochondrial	ADJ
gs-3960	368	33	epitranscriptome	epitranscriptome	NOUN
gs-3960	368	34	to	to	PART
gs-3960	368	35	improve	improve	VERB
gs-3960	368	36	the	the	DET
gs-3960	368	37	fidelity	fidelity	NOUN
gs-3960	368	38	of	of	ADP
gs-3960	368	39	mitochondrial	mitochondrial	ADJ
gs-3960	368	40	protein	protein	NOUN
gs-3960	368	41	synthesis	synthesis	NOUN
gs-3960	368	42	;	;	PUNCT
gs-3960	368	43	small	small	ADJ
gs-3960	368	44	molecules	molecule	NOUN
gs-3960	368	45	that	that	PRON
gs-3960	368	46	enhance	enhance	VERB
gs-3960	368	47	interorganelle	interorganelle	ADJ
gs-3960	368	48	communication	communication	NOUN
gs-3960	368	49	to	to	PART
gs-3960	368	50	restore	restore	VERB
gs-3960	368	51	coordinated	coordinated	ADJ
gs-3960	368	52	stress	stress	NOUN
gs-3960	368	53	responses	response	NOUN
gs-3960	368	54	;	;	PUNCT
gs-3960	368	55	pharmacological	pharmacological	ADJ
gs-3960	368	56	chaperones	chaperone	NOUN
gs-3960	368	57	that	that	PRON
gs-3960	368	58	stabilize	stabilize	VERB
gs-3960	368	59	the	the	DET
gs-3960	368	60	mitochondrial	mitochondrial	ADJ
gs-3960	368	61	protein	protein	NOUN
gs-3960	368	62	import	import	NOUN
gs-3960	368	63	machinery	machinery	NOUN
gs-3960	368	64	microbial	microbial	ADJ
gs-3960	368	65	interventions	intervention	NOUN
gs-3960	368	66	aimed	aim	VERB
gs-3960	368	67	at	at	ADP
gs-3960	368	68	shifting	shift	VERB
gs-3960	368	69	the	the	DET
gs-3960	368	70	gut	gut	NOUN
gs-3960	368	71	microbiome	microbiome	NOUN
gs-3960	368	72	toward	toward	ADP
gs-3960	368	73	strains	strain	NOUN
gs-3960	368	74	that	that	PRON
gs-3960	368	75	produce	produce	VERB
gs-3960	368	76	beneficial	beneficial	ADJ
gs-3960	368	77	mitochondrial	mitochondrial	ADJ
gs-3960	368	78	-	-	PUNCT
gs-3960	368	79	modulating	modulate	VERB
gs-3960	368	80	metabolites	metabolite	NOUN
gs-3960	368	81	;	;	PUNCT
gs-3960	368	82	activity	activity	NOUN
gs-3960	368	83	-	-	PUNCT
gs-3960	368	84	dependent	dependent	ADJ
gs-3960	368	85	mitochondrial	mitochondrial	ADJ
gs-3960	368	86	enhancers	enhancer	NOUN
gs-3960	368	87	that	that	PRON
gs-3960	368	88	restore	restore	VERB
gs-3960	368	89	proper	proper	ADJ
gs-3960	368	90	organelle	organelle	NOUN
gs-3960	368	91	redistribution	redistribution	NOUN
gs-3960	368	92	during	during	ADP
gs-3960	368	93	neuronal	neuronal	ADJ
gs-3960	368	94	firing	firing	NOUN
gs-3960	368	95	;	;	PUNCT
gs-3960	368	96	epigenetic	epigenetic	ADJ
gs-3960	368	97	modifiers	modifier	NOUN
gs-3960	368	98	targeting	target	VERB
gs-3960	368	99	the	the	DET
gs-3960	368	100	mitochondrial	mitochondrial	ADJ
gs-3960	368	101	clock	clock	NOUN
gs-3960	368	102	to	to	PART
gs-3960	368	103	reverse	reverse	VERB
gs-3960	368	104	aspects	aspect	NOUN
gs-3960	368	105	of	of	ADP
gs-3960	368	106	accelerated	accelerate	VERB
gs-3960	368	107	cellular	cellular	ADJ
gs-3960	368	108	aging	aging	NOUN
gs-3960	368	109	;	;	PUNCT
gs-3960	368	110	these	these	DET
gs-3960	368	111	innovative	innovative	ADJ
gs-3960	368	112	approaches	approach	NOUN
gs-3960	368	113	reflect	reflect	VERB
gs-3960	368	114	the	the	DET
gs-3960	368	115	growing	grow	VERB
gs-3960	368	116	appreciation	appreciation	NOUN
gs-3960	368	117	of	of	ADP
gs-3960	368	118	mitochondria	mitochondria	NOUN
gs-3960	368	119	as	as	ADP
gs-3960	368	120	complex	complex	ADJ
gs-3960	368	121	,	,	PUNCT
gs-3960	368	122	dynamic	dynamic	ADJ
gs-3960	368	123	systems	system	NOUN
gs-3960	368	124	that	that	PRON
gs-3960	368	125	require	require	VERB
gs-3960	368	126	multifaceted	multifaceted	ADJ
gs-3960	368	127	interventions	intervention	NOUN
gs-3960	368	128	to	to	PART
gs-3960	368	129	restore	restore	VERB
gs-3960	368	130	proper	proper	ADJ
gs-3960	368	131	function	function	NOUN
gs-3960	368	132	in	in	ADP
gs-3960	368	133	parkinson	parkinson	NOUN
gs-3960	368	134	's	's	PART
gs-3960	368	135	disease	disease	NOUN
gs-3960	368	136	.	.	PUNCT
gs-3960	369	1	integrating	integrate	VERB
gs-3960	369	2	mitochondrial	mitochondrial	ADJ
gs-3960	369	3	medicine	medicine	NOUN
gs-3960	369	4	into	into	ADP
gs-3960	369	5	clinical	clinical	ADJ
gs-3960	369	6	practice	practice	NOUN
gs-3960	369	7	as	as	SCONJ
gs-3960	369	8	these	these	DET
gs-3960	369	9	scientific	scientific	ADJ
gs-3960	369	10	advances	advance	NOUN
gs-3960	369	11	mature	mature	ADJ
gs-3960	369	12	,	,	PUNCT
gs-3960	369	13	the	the	DET
gs-3960	369	14	challenge	challenge	NOUN
gs-3960	369	15	becomes	becomes	AUX
gs-3960	369	16	translating	translate	VERB
gs-3960	369	17	them	they	PRON
gs-3960	369	18	into	into	ADP
gs-3960	369	19	clinically	clinically	ADV
gs-3960	369	20	viable	viable	ADJ
gs-3960	369	21	strategies	strategy	NOUN
gs-3960	369	22	.	.	PUNCT
gs-3960	370	1	personalized	personalize	VERB
gs-3960	370	2	mitochondrial	mitochondrial	ADJ
gs-3960	370	3	medicine	medicine	NOUN
gs-3960	370	4	approaches	approach	NOUN
gs-3960	370	5	are	be	AUX
gs-3960	370	6	emerging	emerge	VERB
gs-3960	370	7	,	,	PUNCT
gs-3960	370	8	where	where	SCONJ
gs-3960	370	9	patients	patient	NOUN
gs-3960	370	10	are	be	AUX
gs-3960	370	11	stratified	stratify	VERB
gs-3960	370	12	based	base	VERB
gs-3960	370	13	on	on	ADP
gs-3960	370	14	their	their	PRON
gs-3960	370	15	specific	specific	ADJ
gs-3960	370	16	mitochondrial	mitochondrial	ADJ
gs-3960	370	17	dysfunction	dysfunction	NOUN
gs-3960	370	18	patterns	pattern	NOUN
gs-3960	370	19	.	.	PUNCT
gs-3960	371	1	some	some	DET
gs-3960	371	2	individuals	individual	NOUN
gs-3960	371	3	may	may	AUX
gs-3960	371	4	primarily	primarily	ADV
gs-3960	371	5	exhibit	exhibit	VERB
gs-3960	371	6	import	import	NOUN
gs-3960	371	7	defects	defect	NOUN
gs-3960	371	8	,	,	PUNCT
gs-3960	371	9	while	while	SCONJ
gs-3960	371	10	others	other	NOUN
gs-3960	371	11	show	show	VERB
gs-3960	371	12	predominant	predominant	ADJ
gs-3960	371	13	respiratory	respiratory	ADJ
gs-3960	371	14	chain	chain	NOUN
gs-3960	371	15	assembly	assembly	NOUN
gs-3960	371	16	problems	problem	NOUN
gs-3960	371	17	or	or	CCONJ
gs-3960	371	18	quality	quality	NOUN
gs-3960	371	19	control	control	NOUN
gs-3960	371	20	deficiencies	deficiency	NOUN
gs-3960	371	21	.	.	PUNCT
gs-3960	372	1	georgian	georgian	NOUN
gs-3960	372	2	scientists/	scientists/	NUM
gs-3960	372	3	.	.	PUNCT
gs-3960	373	1	7	7	NUM
gs-3960	373	2	n	n	PRON
gs-3960	373	3	3	3	NUM
gs-3960	373	4	,	,	PUNCT
gs-3960	373	5	2025	2025	NUM
gs-3960	373	6	421	421	NUM
gs-3960	373	7	diagnostic	diagnostic	ADJ
gs-3960	373	8	tools	tool	NOUN
gs-3960	373	9	are	be	AUX
gs-3960	373	10	being	be	AUX
gs-3960	373	11	developed	develop	VERB
gs-3960	373	12	to	to	PART
gs-3960	373	13	identify	identify	VERB
gs-3960	373	14	these	these	DET
gs-3960	373	15	subtypes	subtype	NOUN
gs-3960	373	16	,	,	PUNCT
gs-3960	373	17	including	include	VERB
gs-3960	373	18	advanced	advanced	ADJ
gs-3960	373	19	functional	functional	ADJ
gs-3960	373	20	imaging	imaging	NOUN
gs-3960	373	21	of	of	ADP
gs-3960	373	22	mitochondrial	mitochondrial	ADJ
gs-3960	373	23	networks	network	NOUN
gs-3960	373	24	in	in	ADP
gs-3960	373	25	living	live	VERB
gs-3960	373	26	neurons	neuron	NOUN
gs-3960	373	27	derived	derive	VERB
gs-3960	373	28	from	from	ADP
gs-3960	373	29	patient	patient	ADJ
gs-3960	373	30	stem	stem	NOUN
gs-3960	373	31	cells	cell	NOUN
gs-3960	373	32	.	.	PUNCT
gs-3960	374	1	such	such	ADJ
gs-3960	374	2	approaches	approach	NOUN
gs-3960	374	3	will	will	AUX
gs-3960	374	4	enable	enable	VERB
gs-3960	374	5	targeted	targeted	ADJ
gs-3960	374	6	selection	selection	NOUN
gs-3960	374	7	of	of	ADP
gs-3960	374	8	mitochondrial	mitochondrial	ADJ
gs-3960	374	9	therapies	therapy	NOUN
gs-3960	374	10	most	most	ADV
gs-3960	374	11	likely	likely	ADJ
gs-3960	374	12	to	to	PART
gs-3960	374	13	benefit	benefit	VERB
gs-3960	374	14	individual	individual	ADJ
gs-3960	374	15	patients	patient	NOUN
gs-3960	374	16	,	,	PUNCT
gs-3960	374	17	moving	move	VERB
gs-3960	374	18	beyond	beyond	ADP
gs-3960	374	19	the	the	DET
gs-3960	374	20	current	current	ADJ
gs-3960	374	21	one	one	NUM
gs-3960	374	22	-	-	PUNCT
gs-3960	374	23	size	size	NOUN
gs-3960	374	24	-	-	PUNCT
gs-3960	374	25	fits	fit	VERB
gs-3960	374	26	-	-	PUNCT
gs-3960	374	27	all	all	DET
gs-3960	374	28	paradigm	paradigm	NOUN
gs-3960	374	29	.	.	PUNCT
gs-3960	375	1	mitochondrial	mitochondrial	ADJ
gs-3960	375	2	dysfunction	dysfunction	NOUN
gs-3960	375	3	in	in	ADP
gs-3960	375	4	parkinson	parkinson	NOUN
gs-3960	375	5	's	's	PART
gs-3960	375	6	disease	disease	NOUN
gs-3960	375	7	critical	critical	ADJ
gs-3960	375	8	role	role	NOUN
gs-3960	375	9	in	in	ADP
gs-3960	375	10	the	the	DET
gs-3960	375	11	degeneration	degeneration	NOUN
gs-3960	375	12	of	of	ADP
gs-3960	375	13	dopaminergic	dopaminergic	ADJ
gs-3960	375	14	neurons	neuron	NOUN
gs-3960	375	15	.	.	PUNCT
gs-3960	376	1	a	a	DET
gs-3960	376	2	key	key	ADJ
gs-3960	376	3	feature	feature	NOUN
gs-3960	376	4	of	of	ADP
gs-3960	376	5	this	this	DET
gs-3960	376	6	dysfunction	dysfunction	NOUN
gs-3960	376	7	is	be	AUX
gs-3960	376	8	impaired	impaired	ADJ
gs-3960	376	9	bioenergetics	bioenergetic	NOUN
gs-3960	376	10	,	,	PUNCT
gs-3960	376	11	with	with	ADP
gs-3960	376	12	mitochondrial	mitochondrial	ADJ
gs-3960	376	13	defects	defect	NOUN
gs-3960	376	14	leading	lead	VERB
gs-3960	376	15	to	to	ADP
gs-3960	376	16	electron	electron	NOUN
gs-3960	376	17	transport	transport	NOUN
gs-3960	376	18	chain	chain	NOUN
gs-3960	376	19	adenosine	adenosine	NOUN
gs-3960	376	20	tri	tri	ADJ
gs-3960	376	21	phosphate	phosphate	NOUN
gs-3960	376	22	(	(	PUNCT
gs-3960	376	23	atp	atp	PROPN
gs-3960	376	24	)	)	PUNCT
gs-3960	376	25	production	production	NOUN
gs-3960	376	26	and	and	CCONJ
gs-3960	376	27	increased	increase	VERB
gs-3960	376	28	oxidative	oxidative	ADJ
gs-3960	376	29	stress	stress	NOUN
gs-3960	376	30	.	.	PUNCT
gs-3960	377	1	this	this	DET
gs-3960	377	2	bioenergetic	bioenergetic	ADJ
gs-3960	377	3	failure	failure	NOUN
gs-3960	377	4	contributes	contribute	VERB
gs-3960	377	5	to	to	ADP
gs-3960	377	6	the	the	DET
gs-3960	377	7	accumulation	accumulation	NOUN
gs-3960	377	8	of	of	ADP
gs-3960	377	9	reactive	reactive	ADJ
gs-3960	377	10	oxygen	oxygen	NOUN
gs-3960	377	11	species	specie	NOUN
gs-3960	377	12	(	(	PUNCT
gs-3960	377	13	ros	ros	PROPN
gs-3960	377	14	)	)	PUNCT
gs-3960	377	15	,	,	PUNCT
gs-3960	377	16	which	which	PRON
gs-3960	377	17	further	far	ADV
gs-3960	377	18	damage	damage	VERB
gs-3960	377	19	mitochondrial	mitochondrial	ADJ
gs-3960	377	20	dna	dna	NOUN
gs-3960	377	21	(	(	PUNCT
gs-3960	377	22	mtdna	mtdna	NOUN
gs-3960	377	23	)	)	PUNCT
gs-3960	377	24	,	,	PUNCT
gs-3960	377	25	exacerbating	exacerbate	VERB
gs-3960	377	26	neurodegeneration	neurodegeneration	NOUN
gs-3960	377	27	[	[	X
gs-3960	377	28	1,2	1,2	NUM
gs-3960	377	29	]	]	PUNCT
gs-3960	377	30	.	.	PUNCT
gs-3960	378	1	genetic	genetic	ADJ
gs-3960	378	2	mutations	mutation	NOUN
gs-3960	378	3	also	also	ADV
gs-3960	378	4	play	play	VERB
gs-3960	378	5	a	a	DET
gs-3960	378	6	crucial	crucial	ADJ
gs-3960	378	7	role	role	NOUN
gs-3960	378	8	in	in	ADP
gs-3960	378	9	mitochondrial	mitochondrial	ADJ
gs-3960	378	10	dysfunction	dysfunction	NOUN
gs-3960	378	11	in	in	ADP
gs-3960	378	12	pd	pd	PROPN
gs-3960	378	13	.	.	PUNCT
gs-3960	378	14	mutations	mutation	NOUN
gs-3960	378	15	in	in	ADP
gs-3960	378	16	genes	gene	NOUN
gs-3960	378	17	such	such	ADJ
gs-3960	378	18	as	as	ADP
gs-3960	378	19	pink1	pink1	NOUN
gs-3960	378	20	and	and	CCONJ
gs-3960	378	21	parkin	parkin	NOUN
gs-3960	378	22	,	,	PUNCT
gs-3960	378	23	which	which	PRON
gs-3960	378	24	regulate	regulate	VERB
gs-3960	378	25	mitochondrial	mitochondrial	ADJ
gs-3960	378	26	dynamics	dynamic	NOUN
gs-3960	378	27	,	,	PUNCT
gs-3960	378	28	mitochondrial	mitochondrial	ADJ
gs-3960	378	29	integrity	integrity	NOUN
gs-3960	378	30	[	[	X
gs-3960	378	31	3,4	3,4	NUM
gs-3960	378	32	]	]	PUNCT
gs-3960	378	33	.	.	PUNCT
gs-3960	379	1	additionally	additionally	ADV
gs-3960	379	2	,	,	PUNCT
gs-3960	379	3	impairments	impairment	NOUN
gs-3960	379	4	in	in	ADP
gs-3960	379	5	mitochondrial	mitochondrial	ADJ
gs-3960	379	6	quality	quality	NOUN
gs-3960	379	7	control	control	NOUN
gs-3960	379	8	mechanisms	mechanism	NOUN
gs-3960	379	9	,	,	PUNCT
gs-3960	379	10	particularly	particularly	ADV
gs-3960	379	11	mitophagy	mitophagy	ADJ
gs-3960	379	12	,	,	PUNCT
gs-3960	379	13	hinder	hinder	VERB
gs-3960	379	14	the	the	DET
gs-3960	379	15	clearance	clearance	NOUN
gs-3960	379	16	of	of	ADP
gs-3960	379	17	damaged	damage	VERB
gs-3960	379	18	mitochondria	mitochondria	NOUN
gs-3960	379	19	,	,	PUNCT
gs-3960	379	20	further	far	ADV
gs-3960	379	21	contributing	contribute	VERB
gs-3960	379	22	to	to	ADP
gs-3960	379	23	disease	disease	NOUN
gs-3960	379	24	progression	progression	NOUN
gs-3960	379	25	.	.	PUNCT
gs-3960	380	1	beyond	beyond	ADP
gs-3960	380	2	defective	defective	ADJ
gs-3960	380	3	mitophagy	mitophagy	NOUN
gs-3960	380	4	,	,	PUNCT
gs-3960	380	5	evidence	evidence	NOUN
gs-3960	380	6	suggests	suggest	VERB
gs-3960	380	7	that	that	SCONJ
gs-3960	380	8	disruptions	disruption	NOUN
gs-3960	380	9	in	in	ADP
gs-3960	380	10	mitochondrial	mitochondrial	ADJ
gs-3960	380	11	biogenesis	biogenesis	NOUN
gs-3960	380	12	and	and	CCONJ
gs-3960	380	13	dynamics	dynamic	NOUN
gs-3960	380	14	also	also	ADV
gs-3960	380	15	contribute	contribute	VERB
gs-3960	380	16	significantly	significantly	ADV
gs-3960	380	17	to	to	ADP
gs-3960	380	18	neuronal	neuronal	ADJ
gs-3960	380	19	loss	loss	NOUN
gs-3960	380	20	.	.	PUNCT
gs-3960	381	1	given	give	VERB
gs-3960	381	2	that	that	DET
gs-3960	381	3	mitochondria	mitochondria	NOUN
gs-3960	381	4	are	be	AUX
gs-3960	381	5	essential	essential	ADJ
gs-3960	381	6	for	for	ADP
gs-3960	381	7	atp	atp	NOUN
gs-3960	381	8	production	production	NOUN
gs-3960	381	9	and	and	CCONJ
gs-3960	381	10	cellular	cellular	ADJ
gs-3960	381	11	energy	energy	NOUN
gs-3960	381	12	metabolism	metabolism	NOUN
gs-3960	381	13	,	,	PUNCT
gs-3960	381	14	their	their	PRON
gs-3960	381	15	of	of	ADP
gs-3960	381	16	pd	pd	PROPN
gs-3960	381	17	pathology	pathology	NOUN
gs-3960	381	18	[	[	X
gs-3960	381	19	5	5	NUM
gs-3960	381	20	-	-	SYM
gs-3960	381	21	6	6	NUM
gs-3960	381	22	]	]	PUNCT
gs-3960	381	23	.	.	PUNCT
gs-3960	382	1	understanding	understand	VERB
gs-3960	382	2	these	these	DET
gs-3960	382	3	mitochondrial	mitochondrial	ADJ
gs-3960	382	4	impairments	impairment	NOUN
gs-3960	382	5	provides	provide	VERB
gs-3960	382	6	critical	critical	ADJ
gs-3960	382	7	insight	insight	NOUN
gs-3960	382	8	into	into	ADP
gs-3960	382	9	the	the	DET
gs-3960	382	10	pathogenesis	pathogenesis	NOUN
gs-3960	382	11	of	of	ADP
gs-3960	382	12	pd	pd	PROPN
gs-3960	382	13	and	and	CCONJ
gs-3960	382	14	highlights	highlight	NOUN
gs-3960	382	15	potential	potential	ADJ
gs-3960	382	16	therapeutic	therapeutic	ADJ
gs-3960	382	17	targets	target	NOUN
gs-3960	382	18	aimed	aim	VERB
gs-3960	382	19	at	at	ADP
gs-3960	382	20	restoring	restore	VERB
gs-3960	382	21	mitochondrial	mitochondrial	ADJ
gs-3960	382	22	function	function	NOUN
gs-3960	382	23	.	.	PUNCT
gs-3960	383	1	mitophagy	mitophagy	NOUN
gs-3960	383	2	in	in	ADP
gs-3960	383	3	parkinson	parkinson	NOUN
gs-3960	383	4	's	's	PART
gs-3960	383	5	disease	disease	NOUN
gs-3960	383	6	mitophagy	mitophagy	NOUN
gs-3960	383	7	,	,	PUNCT
gs-3960	383	8	the	the	DET
gs-3960	383	9	selective	selective	ADJ
gs-3960	383	10	autophagic	autophagic	ADJ
gs-3960	383	11	process	process	NOUN
gs-3960	383	12	that	that	PRON
gs-3960	383	13	removes	remove	VERB
gs-3960	383	14	damaged	damaged	ADJ
gs-3960	383	15	mitochondria	mitochondria	NOUN
gs-3960	383	16	,	,	PUNCT
gs-3960	383	17	is	be	AUX
gs-3960	383	18	essential	essential	ADJ
gs-3960	383	19	for	for	ADP
gs-3960	383	20	maintaining	maintain	VERB
gs-3960	383	21	cellular	cellular	ADJ
gs-3960	383	22	homeostasis	homeostasis	NOUN
gs-3960	383	23	,	,	PUNCT
gs-3960	383	24	particularly	particularly	ADV
gs-3960	383	25	in	in	ADP
gs-3960	383	26	neurons	neuron	NOUN
gs-3960	383	27	.	.	PUNCT
gs-3960	384	1	the	the	DET
gs-3960	384	2	pink1	pink1	NOUN
gs-3960	384	3	/	/	SYM
gs-3960	384	4	parkin	parkin	NOUN
gs-3960	384	5	under	under	ADP
gs-3960	384	6	normal	normal	ADJ
gs-3960	384	7	conditions	condition	NOUN
gs-3960	384	8	,	,	PUNCT
gs-3960	384	9	pink1	pink1	NOUN
gs-3960	384	10	is	be	AUX
gs-3960	384	11	imported	import	VERB
gs-3960	384	12	into	into	ADP
gs-3960	384	13	healthy	healthy	ADJ
gs-3960	384	14	mitochondria	mitochondria	NOUN
gs-3960	384	15	and	and	CCONJ
gs-3960	384	16	degraded	degraded	ADJ
gs-3960	384	17	.	.	PUNCT
gs-3960	385	1	however	however	ADV
gs-3960	385	2	,	,	PUNCT
gs-3960	385	3	in	in	ADP
gs-3960	385	4	damaged	damaged	ADJ
gs-3960	385	5	mitochondria	mitochondria	NOUN
gs-3960	385	6	,	,	PUNCT
gs-3960	385	7	pink1	pink1	NOUN
gs-3960	385	8	accumulates	accumulate	VERB
gs-3960	385	9	on	on	ADP
gs-3960	385	10	the	the	DET
gs-3960	385	11	outer	outer	ADJ
gs-3960	385	12	mitochondrial	mitochondrial	ADJ
gs-3960	385	13	membrane	membrane	NOUN
gs-3960	385	14	,	,	PUNCT
gs-3960	385	15	where	where	SCONJ
gs-3960	385	16	it	it	PRON
gs-3960	385	17	recruits	recruit	VERB
gs-3960	385	18	parkin	parkin	NOUN
gs-3960	385	19	,	,	PUNCT
gs-3960	385	20	an	an	DET
gs-3960	385	21	e3	e3	NOUN
gs-3960	385	22	ubiquitin	ubiquitin	NOUN
gs-3960	385	23	ligase	ligase	NOUN
gs-3960	385	24	.	.	PUNCT
gs-3960	386	1	parkin	parkin	PROPN
gs-3960	386	2	ubiquitinates	ubiquitinate	NOUN
gs-3960	386	3	mitochondrial	mitochondrial	ADJ
gs-3960	386	4	proteins	protein	NOUN
gs-3960	386	5	,	,	PUNCT
gs-3960	386	6	marking	mark	VERB
gs-3960	386	7	the	the	DET
gs-3960	386	8	mitochondria	mitochondria	NOUN
gs-3960	386	9	for	for	ADP
gs-3960	386	10	degradation	degradation	NOUN
gs-3960	386	11	via	via	ADP
gs-3960	386	12	the	the	DET
gs-3960	386	13	autophagic	autophagic	ADJ
gs-3960	386	14	machinery	machinery	NOUN
gs-3960	386	15	[	[	X
gs-3960	386	16	7	7	NUM
gs-3960	386	17	-	-	SYM
gs-3960	386	18	8	8	NUM
gs-3960	386	19	]	]	PUNCT
gs-3960	386	20	.	.	PUNCT
gs-3960	387	1	genetic	genetic	ADJ
gs-3960	387	2	mutations	mutation	NOUN
gs-3960	387	3	in	in	ADP
gs-3960	387	4	pink1	pink1	NOUN
gs-3960	387	5	and	and	CCONJ
gs-3960	387	6	parkin	parkin	ADJ
gs-3960	387	7	impair	impair	NOUN
gs-3960	387	8	this	this	DET
gs-3960	387	9	mitophagic	mitophagic	NOUN
gs-3960	387	10	process	process	NOUN
gs-3960	387	11	and	and	CCONJ
gs-3960	387	12	are	be	AUX
gs-3960	387	13	linked	link	VERB
gs-3960	387	14	to	to	ADP
gs-3960	387	15	early	early	ADJ
gs-3960	387	16	-	-	PUNCT
gs-3960	387	17	onset	onset	NOUN
gs-3960	387	18	familial	familial	ADJ
gs-3960	387	19	pd	pd	NOUN
gs-3960	387	20	,	,	PUNCT
gs-3960	387	21	leading	lead	VERB
gs-3960	387	22	to	to	ADP
gs-3960	387	23	the	the	DET
gs-3960	387	24	accumulation	accumulation	NOUN
gs-3960	387	25	of	of	ADP
gs-3960	387	26	dysfunctional	dysfunctional	ADJ
gs-3960	387	27	mitochondria	mitochondria	NOUN
gs-3960	387	28	.	.	PUNCT
gs-3960	388	1	environmental	environmental	ADJ
gs-3960	388	2	factors	factor	NOUN
gs-3960	388	3	,	,	PUNCT
gs-3960	388	4	such	such	ADJ
gs-3960	388	5	as	as	ADP
gs-3960	388	6	toxins	toxin	NOUN
gs-3960	388	7	,	,	PUNCT
gs-3960	388	8	can	can	AUX
gs-3960	388	9	also	also	ADV
gs-3960	388	10	induce	induce	VERB
gs-3960	388	11	mitochondrial	mitochondrial	ADJ
gs-3960	388	12	damage	damage	NOUN
gs-3960	388	13	georgian	georgian	NOUN
gs-3960	388	14	scientists/	scientists/	NUM
gs-3960	388	15	.	.	PUNCT
gs-3960	389	1	7	7	NUM
gs-3960	389	2	n	n	PRON
gs-3960	389	3	3	3	NUM
gs-3960	389	4	,	,	PUNCT
gs-3960	389	5	2025	2025	NUM
gs-3960	389	6	422	422	NUM
gs-3960	389	7	and	and	CCONJ
gs-3960	389	8	disrupt	disrupt	VERB
gs-3960	389	9	mitophagy	mitophagy	NOUN
gs-3960	389	10	,	,	PUNCT
gs-3960	389	11	contributing	contribute	VERB
gs-3960	389	12	to	to	ADP
gs-3960	389	13	sporadic	sporadic	ADJ
gs-3960	389	14	pd	pd	PROPN
gs-3960	389	15	.	.	PUNCT
gs-3960	390	1	the	the	DET
gs-3960	390	2	failure	failure	NOUN
gs-3960	390	3	of	of	ADP
gs-3960	390	4	mitophagy	mitophagy	NOUN
gs-3960	390	5	results	result	NOUN
gs-3960	390	6	in	in	ADP
gs-3960	390	7	pathogenesis	pathogenesis	NOUN
gs-3960	390	8	.	.	PUNCT
gs-3960	391	1	beyond	beyond	ADP
gs-3960	391	2	the	the	DET
gs-3960	391	3	pink1	pink1	NOUN
gs-3960	391	4	/	/	SYM
gs-3960	391	5	parkin	parkin	NOUN
gs-3960	391	6	pathway	pathway	NOUN
gs-3960	391	7	,	,	PUNCT
gs-3960	391	8	other	other	ADJ
gs-3960	391	9	mitophagy	mitophagy	NOUN
gs-3960	391	10	-	-	PUNCT
gs-3960	391	11	related	relate	VERB
gs-3960	391	12	mechanisms	mechanism	NOUN
gs-3960	391	13	,	,	PUNCT
gs-3960	391	14	including	include	VERB
gs-3960	391	15	the	the	DET
gs-3960	391	16	bnip3	bnip3	NOUN
gs-3960	391	17	,	,	PUNCT
gs-3960	391	18	nix	nix	NOUN
gs-3960	391	19	,	,	PUNCT
gs-3960	391	20	and	and	CCONJ
gs-3960	391	21	fundc1	fundc1	NOUN
gs-3960	391	22	pathways	pathway	NOUN
gs-3960	391	23	,	,	PUNCT
gs-3960	391	24	play	play	VERB
gs-3960	391	25	critical	critical	ADJ
gs-3960	391	26	roles	role	NOUN
gs-3960	391	27	in	in	ADP
gs-3960	391	28	mitochondrial	mitochondrial	ADJ
gs-3960	391	29	clearance	clearance	NOUN
gs-3960	391	30	under	under	ADP
gs-3960	391	31	stress	stress	NOUN
gs-3960	391	32	conditions	condition	NOUN
gs-3960	391	33	.	.	PUNCT
gs-3960	392	1	the	the	DET
gs-3960	392	2	dysregulation	dysregulation	NOUN
gs-3960	392	3	of	of	ADP
gs-3960	392	4	mitophagy	mitophagy	NOUN
gs-3960	392	5	has	have	AUX
gs-3960	392	6	been	be	AUX
gs-3960	392	7	observed	observe	VERB
gs-3960	392	8	in	in	ADP
gs-3960	392	9	underscoring	underscore	VERB
gs-3960	392	10	its	its	PRON
gs-3960	392	11	significance	significance	NOUN
gs-3960	392	12	in	in	ADP
gs-3960	392	13	neuronal	neuronal	ADJ
gs-3960	392	14	health	health	NOUN
gs-3960	392	15	.	.	PUNCT
gs-3960	393	1	given	give	VERB
gs-3960	393	2	the	the	DET
gs-3960	393	3	pivotal	pivotal	ADJ
gs-3960	393	4	role	role	NOUN
gs-3960	393	5	of	of	ADP
gs-3960	393	6	mitophagy	mitophagy	NOUN
gs-3960	393	7	in	in	ADP
gs-3960	393	8	pd	pd	PROPN
gs-3960	393	9	,	,	PUNCT
gs-3960	393	10	therapeutic	therapeutic	ADJ
gs-3960	393	11	strategies	strategy	NOUN
gs-3960	393	12	aimed	aim	VERB
gs-3960	393	13	at	at	ADP
gs-3960	393	14	restoring	restore	VERB
gs-3960	393	15	mitophagic	mitophagic	NOUN
gs-3960	393	16	function	function	NOUN
gs-3960	393	17	are	be	AUX
gs-3960	393	18	being	be	AUX
gs-3960	393	19	actively	actively	ADV
gs-3960	393	20	explored	explore	VERB
gs-3960	393	21	.	.	PUNCT
gs-3960	394	1	potential	potential	ADJ
gs-3960	394	2	approaches	approach	NOUN
gs-3960	394	3	include	include	VERB
gs-3960	394	4	enhancing	enhance	VERB
gs-3960	394	5	pink1	pink1	NOUN
gs-3960	394	6	/	/	SYM
gs-3960	394	7	parkin	parkin	NOUN
gs-3960	394	8	activity	activity	NOUN
gs-3960	394	9	or	or	CCONJ
gs-3960	394	10	utilizing	utilize	VERB
gs-3960	394	11	novel	novel	ADJ
gs-3960	394	12	autophagy	autophagy	NOUN
gs-3960	394	13	-	-	PUNCT
gs-3960	394	14	targeting	target	VERB
gs-3960	394	15	compounds	compound	NOUN
gs-3960	394	16	,	,	PUNCT
gs-3960	394	17	such	such	ADJ
gs-3960	394	18	as	as	ADP
gs-3960	394	19	autacs	autac	NOUN
gs-3960	394	20	,	,	PUNCT
gs-3960	394	21	to	to	PART
gs-3960	394	22	promote	promote	VERB
gs-3960	394	23	mitochondrial	mitochondrial	ADJ
gs-3960	394	24	clearance	clearance	NOUN
gs-3960	394	25	and	and	CCONJ
gs-3960	394	26	mitigate	mitigate	VERB
gs-3960	394	27	neurodegeneration	neurodegeneration	NOUN
gs-3960	394	28	in	in	ADP
gs-3960	394	29	pd	pd	PROPN
gs-3960	394	30	.	.	PUNCT
gs-3960	395	1	nad+	nad+	PROPN
gs-3960	395	2	metabolism	metabolism	NOUN
gs-3960	395	3	and	and	CCONJ
gs-3960	395	4	its	its	PRON
gs-3960	395	5	role	role	NOUN
gs-3960	395	6	in	in	ADP
gs-3960	395	7	parkinson	parkinson	NOUN
gs-3960	395	8	's	's	PART
gs-3960	395	9	disease	disease	NOUN
gs-3960	395	10	nicotinamide	nicotinamide	NOUN
gs-3960	395	11	adenine	adenine	ADJ
gs-3960	395	12	dinucleotide	dinucleotide	NOUN
gs-3960	395	13	(	(	PUNCT
gs-3960	395	14	nad	nad	PROPN
gs-3960	395	15	)	)	PUNCT
gs-3960	395	16	is	be	AUX
gs-3960	395	17	an	an	DET
gs-3960	395	18	essential	essential	ADJ
gs-3960	395	19	cofactor	cofactor	NOUN
gs-3960	395	20	involved	involve	VERB
gs-3960	395	21	in	in	ADP
gs-3960	395	22	cellular	cellular	ADJ
gs-3960	395	23	energy	energy	NOUN
gs-3960	395	24	metabolism	metabolism	NOUN
gs-3960	395	25	,	,	PUNCT
gs-3960	395	26	dna	dna	PROPN
gs-3960	395	27	repair	repair	NOUN
gs-3960	395	28	,	,	PUNCT
gs-3960	395	29	and	and	CCONJ
gs-3960	395	30	redox	redox	ADJ
gs-3960	395	31	balance	balance	NOUN
gs-3960	395	32	.	.	PUNCT
gs-3960	396	1	its	its	PRON
gs-3960	396	2	biosynthesis	biosynthesis	NOUN
gs-3960	396	3	occurs	occur	VERB
gs-3960	396	4	through	through	ADP
gs-3960	396	5	three	three	NUM
gs-3960	396	6	primary	primary	ADJ
gs-3960	396	7	pathways	pathway	NOUN
gs-3960	396	8	:	:	PUNCT
gs-3960	396	9	the	the	DET
gs-3960	396	10	de	de	PROPN
gs-3960	396	11	novo	novo	NOUN
gs-3960	396	12	pathway	pathway	NOUN
gs-3960	396	13	,	,	PUNCT
gs-3960	396	14	the	the	DET
gs-3960	396	15	preiss	preiss	NOUN
gs-3960	396	16	-	-	PUNCT
gs-3960	396	17	handler	handler	NOUN
gs-3960	396	18	pathway	pathway	NOUN
gs-3960	396	19	,	,	PUNCT
gs-3960	396	20	and	and	CCONJ
gs-3960	396	21	the	the	DET
gs-3960	396	22	salvage	salvage	NOUN
gs-3960	396	23	pathway	pathway	NOUN
gs-3960	396	24	.	.	PUNCT
gs-3960	397	1	as	as	ADP
gs-3960	397	2	a	a	DET
gs-3960	397	3	key	key	ADJ
gs-3960	397	4	electron	electron	NOUN
gs-3960	397	5	carrier	carrier	NOUN
gs-3960	397	6	in	in	ADP
gs-3960	397	7	the	the	DET
gs-3960	397	8	mitochondrial	mitochondrial	ADJ
gs-3960	397	9	respiratory	respiratory	ADJ
gs-3960	397	10	chain	chain	NOUN
gs-3960	397	11	,	,	PUNCT
gs-3960	397	12	nad	nad	PROPN
gs-3960	397	13	facilitates	facilitate	VERB
gs-3960	397	14	atp	atp	PROPN
gs-3960	397	15	production	production	NOUN
gs-3960	397	16	through	through	ADP
gs-3960	397	17	oxidative	oxidative	ADJ
gs-3960	397	18	phosphorylation	phosphorylation	NOUN
gs-3960	397	19	,	,	PUNCT
gs-3960	397	20	making	make	VERB
gs-3960	397	21	it	it	PRON
gs-3960	397	22	vital	vital	ADJ
gs-3960	397	23	for	for	ADP
gs-3960	397	24	neuronal	neuronal	ADJ
gs-3960	397	25	survival	survival	NOUN
gs-3960	397	26	and	and	CCONJ
gs-3960	397	27	function	function	NOUN
gs-3960	397	28	.	.	PUNCT
gs-3960	398	1	beyond	beyond	ADP
gs-3960	398	2	its	its	PRON
gs-3960	398	3	role	role	NOUN
gs-3960	398	4	in	in	ADP
gs-3960	398	5	energy	energy	NOUN
gs-3960	398	6	metabolism	metabolism	NOUN
gs-3960	398	7	,	,	PUNCT
gs-3960	398	8	nad	nad	PROPN
gs-3960	398	9	is	be	AUX
gs-3960	398	10	crucial	crucial	ADJ
gs-3960	398	11	for	for	ADP
gs-3960	398	12	dna	dna	PROPN
gs-3960	398	13	repair	repair	NOUN
gs-3960	398	14	as	as	ADP
gs-3960	398	15	a	a	DET
gs-3960	398	16	substrate	substrate	NOUN
gs-3960	398	17	for	for	ADP
gs-3960	398	18	poly	poly	ADJ
gs-3960	398	19	adp	adp	PROPN
gs-3960	398	20	-	-	PUNCT
gs-3960	398	21	ribose	ribose	ADJ
gs-3960	398	22	polymerases	polymerase	NOUN
gs-3960	398	23	(	(	PUNCT
gs-3960	398	24	parps	parps	PROPN
gs-3960	398	25	)	)	PUNCT
gs-3960	398	26	,	,	PUNCT
gs-3960	398	27	which	which	PRON
gs-3960	398	28	mediate	mediate	VERB
gs-3960	398	29	the	the	DET
gs-3960	398	30	repair	repair	NOUN
gs-3960	398	31	of	of	ADP
gs-3960	398	32	dna	dna	PROPN
gs-3960	398	33	strand	strand	NOUN
gs-3960	398	34	breaks	break	NOUN
gs-3960	398	35	.	.	PUNCT
gs-3960	399	1	this	this	DET
gs-3960	399	2	function	function	NOUN
gs-3960	399	3	is	be	AUX
gs-3960	399	4	particularly	particularly	ADV
gs-3960	399	5	important	important	ADJ
gs-3960	399	6	in	in	ADP
gs-3960	399	7	neurons	neuron	NOUN
gs-3960	399	8	,	,	PUNCT
gs-3960	399	9	which	which	PRON
gs-3960	399	10	are	be	AUX
gs-3960	399	11	highly	highly	ADV
gs-3960	399	12	susceptible	susceptible	ADJ
gs-3960	399	13	to	to	ADP
gs-3960	399	14	dna	dna	PROPN
gs-3960	399	15	damage	damage	NOUN
gs-3960	399	16	and	and	CCONJ
gs-3960	399	17	oxidative	oxidative	ADJ
gs-3960	399	18	stress	stress	NOUN
gs-3960	399	19	.	.	PUNCT
gs-3960	400	1	aging	aging	NOUN
gs-3960	400	2	is	be	AUX
gs-3960	400	3	associated	associate	VERB
gs-3960	400	4	with	with	ADP
gs-3960	400	5	a	a	DET
gs-3960	400	6	progressive	progressive	ADJ
gs-3960	400	7	decline	decline	NOUN
gs-3960	400	8	in	in	ADP
gs-3960	400	9	nad	nad	ADJ
gs-3960	400	10	levels	level	NOUN
gs-3960	400	11	,	,	PUNCT
gs-3960	400	12	which	which	PRON
gs-3960	400	13	contributes	contribute	VERB
gs-3960	400	14	to	to	ADP
gs-3960	400	15	hallmarks	hallmark	NOUN
gs-3960	400	16	of	of	ADP
gs-3960	400	17	neurodegenerative	neurodegenerative	ADJ
gs-3960	400	18	diseases	disease	NOUN
gs-3960	400	19	such	such	ADJ
gs-3960	400	20	as	as	ADP
gs-3960	400	21	pd	pd	PROPN
gs-3960	400	22	.	.	PUNCT
gs-3960	401	1	this	this	DET
gs-3960	401	2	decline	decline	NOUN
gs-3960	401	3	exacerbates	exacerbate	VERB
gs-3960	401	4	neuronal	neuronal	ADJ
gs-3960	401	5	vulnerability	vulnerability	NOUN
gs-3960	401	6	and	and	CCONJ
gs-3960	401	7	accelerates	accelerate	VERB
gs-3960	401	8	neurodegeneration	neurodegeneration	NOUN
gs-3960	401	9	.	.	PUNCT
gs-3960	402	1	given	give	VERB
gs-3960	402	2	the	the	DET
gs-3960	402	3	central	central	ADJ
gs-3960	402	4	role	role	NOUN
gs-3960	402	5	of	of	ADP
gs-3960	402	6	nad	nad	PROPN
gs-3960	402	7	in	in	ADP
gs-3960	402	8	mitochondrial	mitochondrial	ADJ
gs-3960	402	9	and	and	CCONJ
gs-3960	402	10	cellular	cellular	ADJ
gs-3960	402	11	homeostasis	homeostasis	NOUN
gs-3960	402	12	,	,	PUNCT
gs-3960	402	13	strategies	strategy	NOUN
gs-3960	402	14	aimed	aim	VERB
gs-3960	402	15	at	at	ADP
gs-3960	402	16	boosting	boost	VERB
gs-3960	402	17	nad	nad	ADJ
gs-3960	402	18	levels	level	NOUN
gs-3960	402	19	have	have	AUX
gs-3960	402	20	gained	gain	VERB
gs-3960	402	21	significant	significant	ADJ
gs-3960	402	22	interest	interest	NOUN
gs-3960	402	23	in	in	ADP
gs-3960	402	24	neuroprotection	neuroprotection	NOUN
gs-3960	402	25	.	.	PUNCT
gs-3960	403	1	supplementation	supplementation	NOUN
gs-3960	403	2	with	with	ADP
gs-3960	403	3	nad	nad	ADJ
gs-3960	403	4	precursors	precursor	NOUN
gs-3960	403	5	,	,	PUNCT
gs-3960	403	6	such	such	ADJ
gs-3960	403	7	as	as	ADP
gs-3960	403	8	nicotinamide	nicotinamide	NOUN
gs-3960	403	9	riboside	riboside	NOUN
gs-3960	403	10	(	(	PUNCT
gs-3960	403	11	nr	nr	NOUN
gs-3960	403	12	)	)	PUNCT
gs-3960	403	13	and	and	CCONJ
gs-3960	403	14	nicotinamide	nicotinamide	NOUN
gs-3960	403	15	mononucleotide	mononucleotide	NOUN
gs-3960	403	16	(	(	PUNCT
gs-3960	403	17	nmn	nmn	PROPN
gs-3960	403	18	)	)	PUNCT
gs-3960	403	19	,	,	PUNCT
gs-3960	403	20	has	have	AUX
gs-3960	403	21	shown	show	VERB
gs-3960	403	22	promising	promise	VERB
gs-3960	403	23	neuroprotective	neuroprotective	ADJ
gs-3960	403	24	effects	effect	NOUN
gs-3960	403	25	in	in	ADP
gs-3960	403	26	preclinical	preclinical	ADJ
gs-3960	403	27	models	model	NOUN
gs-3960	403	28	of	of	ADP
gs-3960	403	29	pd	pd	PROPN
gs-3960	403	30	and	and	CCONJ
gs-3960	403	31	other	other	ADJ
gs-3960	403	32	neurodegenerative	neurodegenerative	ADJ
gs-3960	403	33	disorders	disorder	NOUN
gs-3960	403	34	.	.	PUNCT
gs-3960	404	1	these	these	DET
gs-3960	404	2	interventions	intervention	NOUN
gs-3960	404	3	may	may	AUX
gs-3960	404	4	help	help	VERB
gs-3960	404	5	mitigate	mitigate	VERB
gs-3960	404	6	mitochondrial	mitochondrial	ADJ
gs-3960	404	7	dysfunction	dysfunction	NOUN
gs-3960	404	8	and	and	CCONJ
gs-3960	404	9	oxidative	oxidative	ADJ
gs-3960	404	10	stress	stress	NOUN
gs-3960	404	11	,	,	PUNCT
gs-3960	404	12	offering	offer	VERB
gs-3960	404	13	potential	potential	ADJ
gs-3960	404	14	therapeutic	therapeutic	ADJ
gs-3960	404	15	avenues	avenue	NOUN
gs-3960	404	16	for	for	ADP
gs-3960	404	17	pd	pd	PROPN
gs-3960	404	18	treatment	treatment	NOUN
gs-3960	404	19	.	.	PUNCT
gs-3960	405	1	therapeutic	therapeutic	ADJ
gs-3960	405	2	approaches	approach	NOUN
gs-3960	405	3	targeting	target	VERB
gs-3960	405	4	mitophagy	mitophagy	NOUN
gs-3960	405	5	and	and	CCONJ
gs-3960	405	6	nad+	nad+	PROPN
gs-3960	405	7	metabolism	metabolism	NOUN
gs-3960	405	8	targeting	target	VERB
gs-3960	405	9	mitochondrial	mitochondrial	ADJ
gs-3960	405	10	dysfunction	dysfunction	NOUN
gs-3960	405	11	and	and	CCONJ
gs-3960	405	12	enhancing	enhance	VERB
gs-3960	405	13	mitophagy	mitophagy	NOUN
gs-3960	405	14	present	present	ADJ
gs-3960	405	15	promising	promise	VERB
gs-3960	405	16	georgian	georgian	NOUN
gs-3960	405	17	scientists/	scientists/	NUM
gs-3960	405	18	.	.	PUNCT
gs-3960	406	1	7	7	NUM
gs-3960	406	2	n	n	PRON
gs-3960	406	3	3	3	NUM
gs-3960	406	4	,	,	PUNCT
gs-3960	406	5	2025	2025	NUM
gs-3960	406	6	423	423	NUM
gs-3960	406	7	improving	improve	VERB
gs-3960	406	8	mitochondrial	mitochondrial	ADJ
gs-3960	406	9	bioenergetics	bioenergetic	NOUN
gs-3960	406	10	,	,	PUNCT
gs-3960	406	11	reducing	reduce	VERB
gs-3960	406	12	oxidative	oxidative	ADJ
gs-3960	406	13	stress	stress	NOUN
gs-3960	406	14	,	,	PUNCT
gs-3960	406	15	and	and	CCONJ
gs-3960	406	16	modulating	modulate	VERB
gs-3960	406	17	mitophagy	mitophagy	NOUN
gs-3960	406	18	pathways	pathway	NOUN
gs-3960	406	19	could	could	AUX
gs-3960	406	20	potentially	potentially	ADV
gs-3960	406	21	slow	slow	VERB
gs-3960	406	22	or	or	CCONJ
gs-3960	406	23	halt	halt	VERB
gs-3960	406	24	neurodegeneration	neurodegeneration	NOUN
gs-3960	406	25	.	.	PUNCT
gs-3960	407	1	similarly	similarly	ADV
gs-3960	407	2	,	,	PUNCT
gs-3960	407	3	nad	nad	ADJ
gs-3960	407	4	precursors	precursor	NOUN
gs-3960	407	5	such	such	ADJ
gs-3960	407	6	as	as	ADP
gs-3960	407	7	nicotinamide	nicotinamide	NOUN
gs-3960	407	8	riboside	riboside	NOUN
gs-3960	407	9	(	(	PUNCT
gs-3960	407	10	nr	nr	NOUN
gs-3960	407	11	)	)	PUNCT
gs-3960	407	12	and	and	CCONJ
gs-3960	407	13	nicotinamide	nicotinamide	NOUN
gs-3960	407	14	mononucleotide	mononucleotide	NOUN
gs-3960	407	15	(	(	PUNCT
gs-3960	407	16	nmn	nmn	X
gs-3960	407	17	)	)	PUNCT
gs-3960	407	18	have	have	AUX
gs-3960	407	19	been	be	AUX
gs-3960	407	20	shown	show	VERB
gs-3960	407	21	to	to	PART
gs-3960	407	22	enhance	enhance	VERB
gs-3960	407	23	mitochondrial	mitochondrial	ADJ
gs-3960	407	24	function	function	NOUN
gs-3960	407	25	and	and	CCONJ
gs-3960	407	26	dna	dna	PROPN
gs-3960	407	27	repair	repair	NOUN
gs-3960	407	28	,	,	PUNCT
gs-3960	407	29	potentially	potentially	ADV
gs-3960	407	30	reversing	reverse	VERB
gs-3960	407	31	some	some	DET
gs-3960	407	32	cellular	cellular	ADJ
gs-3960	407	33	deficits	deficit	NOUN
gs-3960	407	34	seen	see	VERB
gs-3960	407	35	in	in	ADP
gs-3960	407	36	pd	pd	PROPN
gs-3960	407	37	.	.	PUNCT
gs-3960	408	1	a	a	DET
gs-3960	408	2	combined	combined	ADJ
gs-3960	408	3	approach	approach	NOUN
gs-3960	408	4	using	use	VERB
gs-3960	408	5	mitophagy	mitophagy	ADJ
gs-3960	408	6	enhancers	enhancer	NOUN
gs-3960	408	7	and	and	CCONJ
gs-3960	408	8	nad	nad	ADJ
gs-3960	408	9	boosters	booster	NOUN
gs-3960	408	10	may	may	AUX
gs-3960	408	11	provide	provide	VERB
gs-3960	408	12	synergistic	synergistic	ADJ
gs-3960	408	13	neuroprotective	neuroprotective	ADJ
gs-3960	408	14	effects	effect	NOUN
gs-3960	408	15	.	.	PUNCT
gs-3960	409	1	for	for	ADP
gs-3960	409	2	example	example	NOUN
gs-3960	409	3	,	,	PUNCT
gs-3960	409	4	compounds	compound	VERB
gs-3960	409	5	like	like	ADP
gs-3960	409	6	urolithin	urolithin	PROPN
gs-3960	409	7	a	a	PRON
gs-3960	409	8	and	and	CCONJ
gs-3960	409	9	resveratrol	resveratrol	NOUN
gs-3960	409	10	,	,	PUNCT
gs-3960	409	11	which	which	PRON
gs-3960	409	12	enhance	enhance	VERB
gs-3960	409	13	mitophagy	mitophagy	NOUN
gs-3960	409	14	,	,	PUNCT
gs-3960	409	15	can	can	AUX
gs-3960	409	16	work	work	VERB
gs-3960	409	17	alongside	alongside	ADP
gs-3960	409	18	nad	nad	ADJ
gs-3960	409	19	boosters	booster	NOUN
gs-3960	409	20	to	to	PART
gs-3960	409	21	improve	improve	VERB
gs-3960	409	22	mitochondrial	mitochondrial	ADJ
gs-3960	409	23	stress	stress	NOUN
gs-3960	409	24	responses	response	NOUN
gs-3960	409	25	and	and	CCONJ
gs-3960	409	26	mitigate	mitigate	VERB
gs-3960	409	27	neurodegeneration	neurodegeneration	NOUN
gs-3960	409	28	in	in	ADP
gs-3960	409	29	pd	pd	PROPN
gs-3960	409	30	.	.	PROPN
gs-3960	409	31	pharmacological	pharmacological	ADJ
gs-3960	409	32	agents	agent	NOUN
gs-3960	409	33	enhancing	enhance	VERB
gs-3960	409	34	mitophagy	mitophagy	NOUN
gs-3960	409	35	in	in	ADP
gs-3960	409	36	pd	pd	PROPN
gs-3960	409	37	several	several	ADJ
gs-3960	409	38	pharmacological	pharmacological	ADJ
gs-3960	409	39	agents	agent	NOUN
gs-3960	409	40	have	have	AUX
gs-3960	409	41	been	be	AUX
gs-3960	409	42	explored	explore	VERB
gs-3960	409	43	for	for	ADP
gs-3960	409	44	their	their	PRON
gs-3960	409	45	ability	ability	NOUN
gs-3960	409	46	to	to	PART
gs-3960	409	47	enhance	enhance	VERB
gs-3960	409	48	mitophagy	mitophagy	NOUN
gs-3960	409	49	and	and	CCONJ
gs-3960	409	50	improve	improve	VERB
gs-3960	409	51	mitochondrial	mitochondrial	ADJ
gs-3960	409	52	function	function	NOUN
gs-3960	409	53	in	in	ADP
gs-3960	409	54	pd	pd	PROPN
gs-3960	409	55	models	model	NOUN
gs-3960	409	56	:	:	PUNCT
gs-3960	409	57	1	1	X
gs-3960	409	58	.	.	PUNCT
gs-3960	409	59	cytarabine	cytarabine	NOUN
gs-3960	409	60	mechanism	mechanism	NOUN
gs-3960	409	61	:	:	PUNCT
gs-3960	409	62	enhances	enhance	VERB
gs-3960	409	63	ampk	ampk	ADJ
gs-3960	409	64	activation	activation	NOUN
gs-3960	409	65	,	,	PUNCT
gs-3960	409	66	stimulating	stimulate	VERB
gs-3960	409	67	pink1	pink1	NOUN
gs-3960	409	68	/	/	SYM
gs-3960	409	69	parkin	parkin	NOUN
gs-3960	409	70	-	-	PUNCT
gs-3960	409	71	mediated	mediate	VERB
gs-3960	409	72	mitophagy	mitophagy	NOUN
gs-3960	409	73	.	.	PUNCT
gs-3960	410	1	effect	effect	NOUN
gs-3960	410	2	:	:	PUNCT
gs-3960	410	3	reduces	reduce	VERB
gs-3960	410	4	oxidative	oxidative	ADJ
gs-3960	410	5	stress	stress	NOUN
gs-3960	410	6	,	,	PUNCT
gs-3960	410	7	improves	improve	VERB
gs-3960	410	8	mitochondrial	mitochondrial	ADJ
gs-3960	410	9	function	function	NOUN
gs-3960	410	10	,	,	PUNCT
gs-3960	410	11	and	and	CCONJ
gs-3960	410	12	alleviates	alleviate	VERB
gs-3960	410	13	motor	motor	NOUN
gs-3960	410	14	symptoms	symptom	NOUN
gs-3960	410	15	in	in	ADP
gs-3960	410	16	rotenone	rotenone	NOUN
gs-3960	410	17	-	-	PUNCT
gs-3960	410	18	induced	induce	VERB
gs-3960	410	19	pd	pd	NOUN
gs-3960	410	20	models	model	NOUN
gs-3960	410	21	.	.	PUNCT
gs-3960	411	1	2	2	X
gs-3960	411	2	.	.	X
gs-3960	411	3	lycopene	lycopene	NOUN
gs-3960	411	4	nanodots	nanodot	NOUN
gs-3960	411	5	mechanism	mechanism	NOUN
gs-3960	411	6	:	:	PUNCT
gs-3960	411	7	delivers	deliver	VERB
gs-3960	411	8	lycopene	lycopene	NOUN
gs-3960	411	9	,	,	PUNCT
gs-3960	411	10	a	a	DET
gs-3960	411	11	natural	natural	ADJ
gs-3960	411	12	antioxidant	antioxidant	NOUN
gs-3960	411	13	,	,	PUNCT
gs-3960	411	14	to	to	PART
gs-3960	411	15	mitochondria	mitochondria	VERB
gs-3960	411	16	via	via	ADP
gs-3960	411	17	sequencetargeted	sequencetargeted	ADJ
gs-3960	411	18	nanodots	nanodot	NOUN
gs-3960	411	19	,	,	PUNCT
gs-3960	411	20	promoting	promote	VERB
gs-3960	411	21	pink1	pink1	NOUN
gs-3960	411	22	/	/	SYM
gs-3960	411	23	parkin	parkin	NOUN
gs-3960	411	24	-	-	PUNCT
gs-3960	411	25	mediated	mediate	VERB
gs-3960	411	26	mitophagy	mitophagy	NOUN
gs-3960	411	27	.	.	PUNCT
gs-3960	412	1	effect	effect	NOUN
gs-3960	412	2	:	:	PUNCT
gs-3960	412	3	protects	protect	VERB
gs-3960	412	4	dopaminergic	dopaminergic	ADJ
gs-3960	412	5	neurons	neuron	NOUN
gs-3960	412	6	and	and	CCONJ
gs-3960	412	7	restores	restore	VERB
gs-3960	412	8	motor	motor	NOUN
gs-3960	412	9	function	function	NOUN
gs-3960	412	10	in	in	ADP
gs-3960	412	11	mptp	mptp	PROPN
gs-3960	412	12	-	-	PUNCT
gs-3960	412	13	induced	induce	VERB
gs-3960	412	14	pd	pd	NOUN
gs-3960	412	15	models	model	NOUN
gs-3960	412	16	.	.	PUNCT
gs-3960	413	1	3	3	X
gs-3960	413	2	.	.	X
gs-3960	413	3	fingolimod	fingolimod	NOUN
gs-3960	413	4	mechanism	mechanism	NOUN
gs-3960	413	5	:	:	PUNCT
gs-3960	413	6	modulates	modulate	VERB
gs-3960	413	7	the	the	DET
gs-3960	413	8	bnip3	bnip3	NOUN
gs-3960	413	9	-	-	PUNCT
gs-3960	413	10	pink1	pink1	NOUN
gs-3960	413	11	-	-	PUNCT
gs-3960	413	12	parkin	parkin	NOUN
gs-3960	413	13	pathway	pathway	NOUN
gs-3960	413	14	,	,	PUNCT
gs-3960	413	15	enhancing	enhance	VERB
gs-3960	413	16	mitophagy	mitophagy	NOUN
gs-3960	413	17	.	.	PUNCT
gs-3960	414	1	effect	effect	NOUN
gs-3960	414	2	:	:	PUNCT
gs-3960	414	3	restores	restore	VERB
gs-3960	414	4	neurobehavioral	neurobehavioral	ADJ
gs-3960	414	5	functions	function	NOUN
gs-3960	414	6	and	and	CCONJ
gs-3960	414	7	reduces	reduce	VERB
gs-3960	414	8	neuropathology	neuropathology	NOUN
gs-3960	414	9	in	in	ADP
gs-3960	414	10	rotenoneinduced	rotenoneinduce	VERB
gs-3960	414	11	pd	pd	NOUN
gs-3960	414	12	models	model	NOUN
gs-3960	414	13	.	.	PUNCT
gs-3960	415	1	4	4	X
gs-3960	415	2	.	.	X
gs-3960	415	3	mtk458	mtk458	ADJ
gs-3960	415	4	mechanism	mechanism	NOUN
gs-3960	415	5	:	:	PUNCT
gs-3960	415	6	activates	activate	VERB
gs-3960	415	7	pink1	pink1	NOUN
gs-3960	415	8	,	,	PUNCT
gs-3960	415	9	enhancing	enhance	VERB
gs-3960	415	10	mitophagy	mitophagy	NOUN
gs-3960	415	11	and	and	CCONJ
gs-3960	415	12	clearing	clear	VERB
gs-3960	415	13	-synuclein	-synuclein	PROPN
gs-3960	415	14	pathology	pathology	NOUN
gs-3960	415	15	.	.	PUNCT
gs-3960	416	1	effect	effect	NOUN
gs-3960	416	2	:	:	PUNCT
gs-3960	416	3	improves	improve	VERB
gs-3960	416	4	mitochondrial	mitochondrial	ADJ
gs-3960	416	5	function	function	NOUN
gs-3960	416	6	and	and	CCONJ
gs-3960	416	7	reduces	reduce	VERB
gs-3960	416	8	-synuclein	-synuclein	ADJ
gs-3960	416	9	aggregation	aggregation	NOUN
gs-3960	416	10	in	in	ADP
gs-3960	416	11	pd	pd	PROPN
gs-3960	416	12	models	model	NOUN
gs-3960	416	13	.	.	PUNCT
gs-3960	417	1	5	5	X
gs-3960	417	2	.	.	X
gs-3960	417	3	dexmedetomidine	dexmedetomidine	ADJ
gs-3960	417	4	mechanism	mechanism	NOUN
gs-3960	417	5	:	:	PUNCT
gs-3960	417	6	enhances	enhance	VERB
gs-3960	417	7	pink1	pink1	NOUN
gs-3960	417	8	/	/	SYM
gs-3960	417	9	parkin	parkin	NOUN
gs-3960	417	10	-	-	PUNCT
gs-3960	417	11	mediated	mediate	VERB
gs-3960	417	12	mitophagy	mitophagy	NOUN
gs-3960	417	13	via	via	ADP
gs-3960	417	14	ampk	ampk	NOUN
gs-3960	417	15	activation	activation	NOUN
gs-3960	417	16	.	.	PUNCT
gs-3960	418	1	effect	effect	NOUN
gs-3960	418	2	:	:	PUNCT
gs-3960	418	3	improves	improve	VERB
gs-3960	418	4	mitochondrial	mitochondrial	ADJ
gs-3960	418	5	function	function	NOUN
gs-3960	418	6	,	,	PUNCT
gs-3960	418	7	reduces	reduce	VERB
gs-3960	418	8	oxidative	oxidative	ADJ
gs-3960	418	9	stress	stress	NOUN
gs-3960	418	10	,	,	PUNCT
gs-3960	418	11	and	and	CCONJ
gs-3960	418	12	protects	protect	VERB
gs-3960	418	13	dopaminergic	dopaminergic	ADJ
gs-3960	418	14	neurons	neuron	NOUN
gs-3960	418	15	in	in	ADP
gs-3960	418	16	mptp	mptp	PROPN
gs-3960	418	17	-	-	PUNCT
gs-3960	418	18	induced	induce	VERB
gs-3960	418	19	pd	pd	NOUN
gs-3960	418	20	models	model	NOUN
gs-3960	418	21	.	.	PUNCT
gs-3960	419	1	6	6	NUM
gs-3960	419	2	.	.	X
gs-3960	419	3	autophagy	autophagy	NOUN
gs-3960	419	4	-	-	PUNCT
gs-3960	419	5	tethering	tether	VERB
gs-3960	419	6	compounds	compound	NOUN
gs-3960	419	7	(	(	PUNCT
gs-3960	419	8	attecs	attecs	NOUN
gs-3960	419	9	)	)	PUNCT
gs-3960	419	10	mechanism	mechanism	NOUN
gs-3960	419	11	:	:	PUNCT
gs-3960	419	12	bifunctional	bifunctional	ADJ
gs-3960	419	13	molecules	molecule	NOUN
gs-3960	419	14	that	that	PRON
gs-3960	419	15	selectively	selectively	ADV
gs-3960	419	16	target	target	VERB
gs-3960	419	17	damaged	damage	VERB
gs-3960	419	18	mitochondria	mitochondria	NOUN
gs-3960	419	19	for	for	ADP
gs-3960	419	20	autophagic	autophagic	ADJ
gs-3960	419	21	degradation	degradation	NOUN
gs-3960	419	22	.	.	PUNCT
gs-3960	420	1	effect	effect	NOUN
gs-3960	420	2	:	:	PUNCT
gs-3960	420	3	clear	clear	ADJ
gs-3960	420	4	damaged	damage	VERB
gs-3960	420	5	mitochondria	mitochondria	NOUN
gs-3960	420	6	and	and	CCONJ
gs-3960	420	7	attenuate	attenuate	VERB
gs-3960	420	8	disease	disease	NOUN
gs-3960	420	9	phenotypes	phenotype	NOUN
gs-3960	420	10	in	in	ADP
gs-3960	420	11	pd	pd	NOUN
gs-3960	420	12	models	model	NOUN
gs-3960	420	13	.	.	PUNCT
gs-3960	421	1	georgian	georgian	NOUN
gs-3960	421	2	scientists/	scientists/	NUM
gs-3960	421	3	.	.	PUNCT
gs-3960	422	1	7	7	NUM
gs-3960	422	2	n	n	PRON
gs-3960	422	3	3	3	NUM
gs-3960	422	4	,	,	PUNCT
gs-3960	422	5	2025	2025	NUM
gs-3960	422	6	424	424	NUM
gs-3960	422	7	therapeutic	therapeutic	ADJ
gs-3960	422	8	strategies	strategy	NOUN
gs-3960	422	9	targeting	target	VERB
gs-3960	422	10	nad	nad	ADJ
gs-3960	422	11	metabolism	metabolism	NOUN
gs-3960	422	12	in	in	ADP
gs-3960	422	13	pd	pd	PROPN
gs-3960	422	14	nad	nad	PROPN
gs-3960	422	15	is	be	AUX
gs-3960	422	16	a	a	DET
gs-3960	422	17	critical	critical	ADJ
gs-3960	422	18	coenzyme	coenzyme	NOUN
gs-3960	422	19	involved	involve	VERB
gs-3960	422	20	in	in	ADP
gs-3960	422	21	mitochondrial	mitochondrial	ADJ
gs-3960	422	22	energy	energy	NOUN
gs-3960	422	23	production	production	NOUN
gs-3960	422	24	and	and	CCONJ
gs-3960	422	25	dna	dna	PROPN
gs-3960	422	26	repair	repair	NOUN
gs-3960	422	27	.	.	PUNCT
gs-3960	423	1	reduced	reduce	VERB
gs-3960	423	2	nad	nad	ADJ
gs-3960	423	3	levels	level	NOUN
gs-3960	423	4	in	in	ADP
gs-3960	423	5	pd	pd	PROPN
gs-3960	423	6	contribute	contribute	VERB
gs-3960	423	7	to	to	ADP
gs-3960	423	8	mitochondrial	mitochondrial	ADJ
gs-3960	423	9	dysfunction	dysfunction	NOUN
gs-3960	423	10	and	and	CCONJ
gs-3960	423	11	neuronal	neuronal	ADJ
gs-3960	423	12	degeneration	degeneration	NOUN
gs-3960	423	13	.	.	PUNCT
gs-3960	424	1	restoring	restore	VERB
gs-3960	424	2	nad	nad	ADJ
gs-3960	424	3	metabolism	metabolism	NOUN
gs-3960	424	4	offers	offer	VERB
gs-3960	424	5	a	a	DET
gs-3960	424	6	promising	promising	ADJ
gs-3960	424	7	therapeutic	therapeutic	ADJ
gs-3960	424	8	strategy	strategy	NOUN
gs-3960	424	9	:	:	PUNCT
gs-3960	424	10	1	1	X
gs-3960	424	11	.	.	X
gs-3960	424	12	nad	nad	ADJ
gs-3960	424	13	precursors	precursor	NOUN
gs-3960	424	14	mechanism	mechanism	NOUN
gs-3960	424	15	:	:	PUNCT
gs-3960	424	16	nmn	nmn	PROPN
gs-3960	424	17	and	and	CCONJ
gs-3960	424	18	nr	nr	PROPN
gs-3960	424	19	supplementation	supplementation	NOUN
gs-3960	424	20	replenish	replenish	VERB
gs-3960	424	21	nad	nad	PROPN
gs-3960	424	22	levels	level	NOUN
gs-3960	424	23	,	,	PUNCT
gs-3960	424	24	supporting	support	VERB
gs-3960	424	25	mitochondrial	mitochondrial	ADJ
gs-3960	424	26	function	function	NOUN
gs-3960	424	27	.	.	PUNCT
gs-3960	425	1	effect	effect	NOUN
gs-3960	425	2	:	:	PUNCT
gs-3960	425	3	protects	protect	VERB
gs-3960	425	4	dopaminergic	dopaminergic	ADJ
gs-3960	425	5	neurons	neuron	NOUN
gs-3960	425	6	,	,	PUNCT
gs-3960	425	7	attenuates	attenuate	NOUN
gs-3960	425	8	apoptosis	apoptosis	NOUN
gs-3960	425	9	,	,	PUNCT
gs-3960	425	10	and	and	CCONJ
gs-3960	425	11	enhances	enhance	VERB
gs-3960	425	12	energy	energy	NOUN
gs-3960	425	13	metabolism	metabolism	NOUN
gs-3960	425	14	.	.	PUNCT
gs-3960	426	1	2	2	X
gs-3960	426	2	.	.	X
gs-3960	426	3	parp	parp	ADJ
gs-3960	426	4	inhibition	inhibition	NOUN
gs-3960	426	5	-consuming	-consume	VERB
gs-3960	426	6	enzymes	enzyme	NOUN
gs-3960	426	7	involved	involve	VERB
gs-3960	426	8	in	in	ADP
gs-3960	426	9	dna	dna	PROPN
gs-3960	426	10	repair	repair	NOUN
gs-3960	426	11	.	.	PUNCT
gs-3960	427	1	effect	effect	NOUN
gs-3960	427	2	:	:	PUNCT
gs-3960	427	3	improves	improve	VERB
gs-3960	427	4	mitochondrial	mitochondrial	ADJ
gs-3960	427	5	function	function	NOUN
gs-3960	427	6	and	and	CCONJ
gs-3960	427	7	reduces	reduce	VERB
gs-3960	427	8	neurotoxicity	neurotoxicity	NOUN
gs-3960	427	9	by	by	ADP
gs-3960	427	10	preserving	preserve	VERB
gs-3960	427	11	nad	nad	ADJ
gs-3960	427	12	availability	availability	NOUN
gs-3960	427	13	.	.	PUNCT
gs-3960	428	1	3	3	X
gs-3960	428	2	.	.	X
gs-3960	428	3	phenothiazine	phenothiazine	NOUN
gs-3960	428	4	mechanism	mechanism	NOUN
gs-3960	428	5	:	:	PUNCT
gs-3960	428	6	normalizes	normalize	VERB
gs-3960	428	7	the	the	DET
gs-3960	428	8	nadh	nadh	NOUN
gs-3960	428	9	/	/	SYM
gs-3960	428	10	nad	nad	ADJ
gs-3960	428	11	ratio	ratio	NOUN
gs-3960	428	12	and	and	CCONJ
gs-3960	428	13	maintains	maintain	VERB
gs-3960	428	14	mitochondrial	mitochondrial	ADJ
gs-3960	428	15	integrity	integrity	NOUN
gs-3960	428	16	.	.	PUNCT
gs-3960	429	1	effect	effect	NOUN
gs-3960	429	2	:	:	PUNCT
gs-3960	429	3	protects	protect	VERB
gs-3960	429	4	the	the	DET
gs-3960	429	5	nigrostriatal	nigrostriatal	ADJ
gs-3960	429	6	dopamine	dopamine	NOUN
gs-3960	429	7	system	system	NOUN
gs-3960	429	8	in	in	ADP
gs-3960	429	9	chronic	chronic	ADJ
gs-3960	429	10	rotenone	rotenone	NOUN
gs-3960	429	11	-	-	PUNCT
gs-3960	429	12	induced	induce	VERB
gs-3960	429	13	pd	pd	NOUN
gs-3960	429	14	models	model	NOUN
gs-3960	429	15	.	.	PUNCT
gs-3960	430	1	integrative	integrative	ADJ
gs-3960	430	2	therapeutic	therapeutic	ADJ
gs-3960	430	3	strategies	strategy	NOUN
gs-3960	430	4	for	for	ADP
gs-3960	430	5	pd	pd	NOUN
gs-3960	430	6	given	give	VERB
gs-3960	430	7	the	the	DET
gs-3960	430	8	interdependence	interdependence	NOUN
gs-3960	430	9	of	of	ADP
gs-3960	430	10	mitophagy	mitophagy	NOUN
gs-3960	430	11	and	and	CCONJ
gs-3960	430	12	nad	nad	ADJ
gs-3960	430	13	metabolism	metabolism	NOUN
gs-3960	430	14	,	,	PUNCT
gs-3960	430	15	combining	combine	VERB
gs-3960	430	16	targeted	target	VERB
gs-3960	430	17	interventions	intervention	NOUN
gs-3960	430	18	may	may	AUX
gs-3960	430	19	provide	provide	VERB
gs-3960	430	20	enhanced	enhanced	ADJ
gs-3960	430	21	neuroprotection	neuroprotection	NOUN
gs-3960	430	22	:	:	PUNCT
gs-3960	430	23	1	1	X
gs-3960	430	24	.	.	X
gs-3960	430	25	small	small	ADJ
gs-3960	430	26	molecule	molecule	NOUN
gs-3960	430	27	activators	activator	NOUN
gs-3960	430	28	of	of	ADP
gs-3960	430	29	mitophagy	mitophagy	ADJ
gs-3960	430	30	example	example	NOUN
gs-3960	430	31	:	:	PUNCT
gs-3960	430	32	mtk458	mtk458	PROPN
gs-3960	430	33	,	,	PUNCT
gs-3960	430	34	which	which	PRON
gs-3960	430	35	targets	target	VERB
gs-3960	430	36	the	the	DET
gs-3960	430	37	pink1	pink1	NOUN
gs-3960	430	38	/	/	SYM
gs-3960	430	39	parkin	parkin	NOUN
gs-3960	430	40	pathway	pathway	NOUN
gs-3960	430	41	,	,	PUNCT
gs-3960	430	42	enhances	enhance	VERB
gs-3960	430	43	mitophagy	mitophagy	ADJ
gs-3960	430	44	.	.	PUNCT
gs-3960	431	1	2	2	X
gs-3960	431	2	.	.	X
gs-3960	431	3	natural	natural	ADJ
gs-3960	431	4	compounds	compound	NOUN
gs-3960	431	5	modulating	modulate	VERB
gs-3960	431	6	mitophagy	mitophagy	NOUN
gs-3960	431	7	example	example	NOUN
gs-3960	431	8	:	:	PUNCT
gs-3960	431	9	lycopene	lycopene	NOUN
gs-3960	431	10	and	and	CCONJ
gs-3960	431	11	polyphenols	polyphenol	NOUN
gs-3960	431	12	regulate	regulate	VERB
gs-3960	431	13	mitophagy	mitophagy	NOUN
gs-3960	431	14	through	through	ADP
gs-3960	431	15	the	the	DET
gs-3960	431	16	pink1	pink1	NOUN
gs-3960	431	17	/	/	SYM
gs-3960	431	18	parkin	parkin	NOUN
gs-3960	431	19	and	and	CCONJ
gs-3960	431	20	bnip3	bnip3	NOUN
gs-3960	431	21	/	/	SYM
gs-3960	431	22	nix	nix	PROPN
gs-3960	431	23	pathways	pathway	NOUN
gs-3960	431	24	,	,	PUNCT
gs-3960	431	25	improving	improve	VERB
gs-3960	431	26	mitochondrial	mitochondrial	ADJ
gs-3960	431	27	function	function	NOUN
gs-3960	431	28	in	in	ADP
gs-3960	431	29	pd	pd	NOUN
gs-3960	431	30	models	model	NOUN
gs-3960	431	31	.	.	PUNCT
gs-3960	432	1	3	3	X
gs-3960	432	2	.	.	X
gs-3960	432	3	nad	nad	ADJ
gs-3960	432	4	precursor	precursor	NOUN
gs-3960	432	5	supplementation	supplementation	NOUN
gs-3960	432	6	example	example	NOUN
gs-3960	432	7	:	:	PUNCT
gs-3960	432	8	nmn	nmn	PROPN
gs-3960	432	9	and	and	CCONJ
gs-3960	432	10	nr	nr	PROPN
gs-3960	432	11	supplementation	supplementation	NOUN
gs-3960	432	12	restore	restore	VERB
gs-3960	432	13	nad	nad	ADJ
gs-3960	432	14	levels	level	NOUN
gs-3960	432	15	,	,	PUNCT
gs-3960	432	16	improving	improve	VERB
gs-3960	432	17	mitochondrial	mitochondrial	ADJ
gs-3960	432	18	function	function	NOUN
gs-3960	432	19	.	.	PUNCT
gs-3960	433	1	4	4	X
gs-3960	433	2	.	.	X
gs-3960	433	3	combination	combination	NOUN
gs-3960	433	4	therapies	therapy	NOUN
gs-3960	433	5	example	example	VERB
gs-3960	433	6	:	:	PUNCT
gs-3960	433	7	combining	combine	VERB
gs-3960	433	8	mitophagy	mitophagy	ADJ
gs-3960	433	9	enhancers	enhancer	NOUN
gs-3960	433	10	(	(	PUNCT
gs-3960	433	11	e.g.	e.g.	ADV
gs-3960	433	12	,	,	PUNCT
gs-3960	433	13	mtk458	mtk458	PROPN
gs-3960	433	14	)	)	PUNCT
gs-3960	433	15	with	with	ADP
gs-3960	433	16	nad	nad	ADJ
gs-3960	433	17	precursor	precursor	NOUN
gs-3960	433	18	supplementation	supplementation	NOUN
gs-3960	433	19	(	(	PUNCT
gs-3960	433	20	e.g.	e.g.	ADV
gs-3960	433	21	,	,	PUNCT
gs-3960	433	22	nmn	nmn	X
gs-3960	433	23	)	)	PUNCT
gs-3960	433	24	may	may	AUX
gs-3960	433	25	synergistically	synergistically	ADV
gs-3960	433	26	improve	improve	VERB
gs-3960	433	27	mitophagy	mitophagy	NOUN
gs-3960	433	28	and	and	CCONJ
gs-3960	433	29	nad	nad	ADJ
gs-3960	433	30	metabolism	metabolism	NOUN
gs-3960	433	31	,	,	PUNCT
gs-3960	433	32	potentially	potentially	ADV
gs-3960	433	33	offering	offer	VERB
gs-3960	433	34	greater	great	ADJ
gs-3960	433	35	neuroprotection	neuroprotection	NOUN
gs-3960	433	36	.	.	PUNCT
gs-3960	434	1	the	the	DET
gs-3960	434	2	pharmacological	pharmacological	ADJ
gs-3960	434	3	agents	agent	NOUN
gs-3960	434	4	targeting	target	VERB
gs-3960	434	5	mitophagy	mitophagy	NOUN
gs-3960	434	6	and	and	CCONJ
gs-3960	434	7	nad+	nad+	PROPN
gs-3960	434	8	metabolism	metabolism	NOUN
gs-3960	434	9	in	in	ADP
gs-3960	434	10	pd	pd	PROPN
gs-3960	434	11	as	as	SCONJ
gs-3960	434	12	discussed	discuss	VERB
gs-3960	434	13	above	above	ADV
gs-3960	434	14	are	be	AUX
gs-3960	434	15	summarized	summarize	VERB
gs-3960	434	16	in	in	ADP
gs-3960	434	17	table	table	NOUN
gs-3960	434	18	1	1	NUM
gs-3960	434	19	.	.	PUNCT
gs-3960	434	20	table	table	NOUN
gs-3960	434	21	1	1	NUM
gs-3960	434	22	:	:	PUNCT
gs-3960	434	23	summary	summary	NOUN
gs-3960	434	24	table	table	NOUN
gs-3960	434	25	:	:	PUNCT
gs-3960	434	26	pharmacological	pharmacological	ADJ
gs-3960	434	27	agents	agent	NOUN
gs-3960	434	28	targeting	target	VERB
gs-3960	434	29	mitophagy	mitophagy	NOUN
gs-3960	434	30	and	and	CCONJ
gs-3960	434	31	nad+	nad+	PROPN
gs-3960	434	32	metabolism	metabolism	NOUN
gs-3960	434	33	in	in	ADP
gs-3960	434	34	pd	pd	PROPN
gs-3960	434	35	georgian	georgian	NOUN
gs-3960	434	36	scientists/	scientists/	NUM
gs-3960	434	37	.	.	PUNCT
gs-3960	435	1	7	7	NUM
gs-3960	435	2	n	n	PRON
gs-3960	435	3	3	3	NUM
gs-3960	435	4	,	,	PUNCT
gs-3960	435	5	2025	2025	NUM
gs-3960	435	6	425	425	NUM
gs-3960	435	7	compound	compound	NOUN
gs-3960	435	8	mechanism	mechanism	NOUN
gs-3960	435	9	of	of	ADP
gs-3960	435	10	action	action	NOUN
gs-3960	435	11	effect	effect	NOUN
gs-3960	435	12	on	on	ADP
gs-3960	435	13	pd	pd	PROPN
gs-3960	435	14	models	model	NOUN
gs-3960	435	15	cytarabine	cytarabine	NOUN
gs-3960	435	16	enhances	enhance	VERB
gs-3960	435	17	ampk	ampk	ADJ
gs-3960	435	18	activation	activation	NOUN
gs-3960	435	19	to	to	PART
gs-3960	435	20	stimulate	stimulate	VERB
gs-3960	435	21	pink1	pink1	NOUN
gs-3960	435	22	/	/	SYM
gs-3960	435	23	parkinmediated	parkinmediate	VERB
gs-3960	435	24	mitophagy	mitophagy	NOUN
gs-3960	435	25	reduces	reduce	VERB
gs-3960	435	26	oxidative	oxidative	ADJ
gs-3960	435	27	stress	stress	NOUN
gs-3960	435	28	,	,	PUNCT
gs-3960	435	29	improves	improve	VERB
gs-3960	435	30	mitochondrial	mitochondrial	ADJ
gs-3960	435	31	function	function	NOUN
gs-3960	435	32	,	,	PUNCT
gs-3960	435	33	and	and	CCONJ
gs-3960	435	34	ameliorates	ameliorate	VERB
gs-3960	435	35	motor	motor	NOUN
gs-3960	435	36	symptoms	symptom	NOUN
gs-3960	435	37	lycopene	lycopene	NOUN
gs-3960	435	38	nanodots	nanodot	NOUN
gs-3960	435	39	promotes	promote	VERB
gs-3960	435	40	pink1	pink1	NOUN
gs-3960	435	41	/	/	SYM
gs-3960	435	42	parkinmediated	parkinmediate	VERB
gs-3960	435	43	mitophagy	mitophagy	NOUN
gs-3960	435	44	through	through	ADP
gs-3960	435	45	targeted	target	VERB
gs-3960	435	46	delivery	delivery	NOUN
gs-3960	435	47	protects	protect	VERB
gs-3960	435	48	dopaminergic	dopaminergic	ADJ
gs-3960	435	49	neurons	neuron	NOUN
gs-3960	435	50	and	and	CCONJ
gs-3960	435	51	restores	restore	VERB
gs-3960	435	52	motor	motor	NOUN
gs-3960	435	53	function	function	NOUN
gs-3960	435	54	in	in	ADP
gs-3960	435	55	mptpinduced	mptpinduced	ADJ
gs-3960	435	56	pd	pd	PROPN
gs-3960	435	57	models	model	NOUN
gs-3960	435	58	fingolimod	fingolimod	PROPN
gs-3960	435	59	regulates	regulate	VERB
gs-3960	435	60	bnip3	bnip3	NOUN
gs-3960	435	61	-	-	PUNCT
gs-3960	435	62	pink1parkin	pink1parkin	NOUN
gs-3960	435	63	-	-	PUNCT
gs-3960	435	64	dependent	dependent	ADJ
gs-3960	435	65	mitophagy	mitophagy	NOUN
gs-3960	435	66	restores	restore	VERB
gs-3960	435	67	neurobehavioral	neurobehavioral	ADJ
gs-3960	435	68	functions	function	NOUN
gs-3960	435	69	and	and	CCONJ
gs-3960	435	70	reduces	reduce	VERB
gs-3960	435	71	neuropathology	neuropathology	NOUN
gs-3960	435	72	in	in	ADP
gs-3960	435	73	rotenoneinduced	rotenoneinduce	VERB
gs-3960	435	74	pd	pd	PROPN
gs-3960	435	75	models	model	NOUN
gs-3960	435	76	mtk458	mtk458	PROPN
gs-3960	435	77	activates	activate	VERB
gs-3960	435	78	pink1	pink1	NOUN
gs-3960	435	79	to	to	PART
gs-3960	435	80	enhance	enhance	VERB
gs-3960	435	81	mitophagy	mitophagy	NOUN
gs-3960	435	82	and	and	CCONJ
gs-3960	435	83	clear	clear	ADJ
gs-3960	435	84	synuclein	synuclein	NOUN
gs-3960	435	85	pathology	pathology	NOUN
gs-3960	435	86	improves	improve	VERB
gs-3960	435	87	mitochondrial	mitochondrial	ADJ
gs-3960	435	88	function	function	NOUN
gs-3960	435	89	and	and	CCONJ
gs-3960	435	90	reduces	reduce	VERB
gs-3960	435	91	-synuclein	-synuclein	ADJ
gs-3960	435	92	pathology	pathology	NOUN
gs-3960	435	93	in	in	ADP
gs-3960	435	94	pd	pd	PROPN
gs-3960	435	95	models	model	NOUN
gs-3960	435	96	dexmedetomidine	dexmedetomidine	PROPN
gs-3960	435	97	enhances	enhance	VERB
gs-3960	435	98	pink1	pink1	NOUN
gs-3960	435	99	/	/	SYM
gs-3960	435	100	parkinmediated	parkinmediate	VERB
gs-3960	435	101	mitophagy	mitophagy	NOUN
gs-3960	435	102	by	by	ADP
gs-3960	435	103	activating	activate	VERB
gs-3960	435	104	ampk	ampk	NOUN
gs-3960	435	105	protects	protect	VERB
gs-3960	435	106	dopaminergic	dopaminergic	ADJ
gs-3960	435	107	neurons	neuron	NOUN
gs-3960	435	108	and	and	CCONJ
gs-3960	435	109	improves	improve	VERB
gs-3960	435	110	mitochondrial	mitochondrial	ADJ
gs-3960	435	111	function	function	NOUN
gs-3960	435	112	in	in	ADP
gs-3960	435	113	mptp	mptp	PROPN
gs-3960	435	114	-	-	PUNCT
gs-3960	435	115	induced	induce	VERB
gs-3960	435	116	pd	pd	PROPN
gs-3960	435	117	models	model	NOUN
gs-3960	435	118	nmn	nmn	PROPN
gs-3960	435	119	restores	restore	VERB
gs-3960	435	120	nad+	nad+	PROPN
gs-3960	435	121	levels	level	NOUN
gs-3960	435	122	and	and	CCONJ
gs-3960	435	123	improves	improve	VERB
gs-3960	435	124	mitochondrial	mitochondrial	ADJ
gs-3960	435	125	function	function	NOUN
gs-3960	435	126	attenuates	attenuate	VERB
gs-3960	435	127	apoptosis	apoptosis	NOUN
gs-3960	435	128	and	and	CCONJ
gs-3960	435	129	improves	improve	VERB
gs-3960	435	130	energy	energy	NOUN
gs-3960	435	131	metabolism	metabolism	NOUN
gs-3960	435	132	in	in	ADP
gs-3960	435	133	rotenonetreated	rotenonetreated	ADJ
gs-3960	435	134	pc12	pc12	PROPN
gs-3960	435	135	cells	cell	NOUN
gs-3960	435	136	phenothiazine	phenothiazine	NOUN
gs-3960	435	137	normalizes	normalize	VERB
gs-3960	435	138	nadh	nadh	NOUN
gs-3960	435	139	/	/	SYM
gs-3960	435	140	nad+	nad+	PROPN
gs-3960	435	141	ratio	ratio	NOUN
gs-3960	435	142	and	and	CCONJ
gs-3960	435	143	maintains	maintain	VERB
gs-3960	435	144	mitochondrial	mitochondrial	ADJ
gs-3960	435	145	integrity	integrity	NOUN
gs-3960	435	146	protects	protect	VERB
gs-3960	435	147	the	the	DET
gs-3960	435	148	nigrostriatal	nigrostriatal	ADJ
gs-3960	435	149	dopamine	dopamine	NOUN
gs-3960	435	150	system	system	NOUN
gs-3960	435	151	in	in	ADP
gs-3960	435	152	chronic	chronic	ADJ
gs-3960	435	153	rotenone	rotenone	NOUN
gs-3960	435	154	models	model	NOUN
gs-3960	435	155	of	of	ADP
gs-3960	435	156	pd	pd	PROPN
gs-3960	435	157	mitochondrial	mitochondrial	ADJ
gs-3960	435	158	dysfunction	dysfunction	NOUN
gs-3960	435	159	,	,	PUNCT
gs-3960	435	160	mitophagy	mitophagy	NOUN
gs-3960	435	161	impairment	impairment	NOUN
gs-3960	435	162	,	,	PUNCT
gs-3960	435	163	and	and	CCONJ
gs-3960	435	164	nad+	nad+	PROPN
gs-3960	435	165	depletion	depletion	NOUN
gs-3960	435	166	are	be	AUX
gs-3960	435	167	central	central	ADJ
gs-3960	435	168	to	to	ADP
gs-3960	435	169	such	such	ADJ
gs-3960	435	170	as	as	ADP
gs-3960	435	171	cytarabine	cytarabine	NOUN
gs-3960	435	172	,	,	PUNCT
gs-3960	435	173	lycopene	lycopene	NOUN
gs-3960	435	174	nanodots	nanodot	NOUN
gs-3960	435	175	,	,	PUNCT
gs-3960	435	176	fingolimod	fingolimod	NOUN
gs-3960	435	177	,	,	PUNCT
gs-3960	435	178	mtk458	mtk458	PROPN
gs-3960	435	179	,	,	PUNCT
gs-3960	435	180	dexmedetomidine	dexmedetomidine	PROPN
gs-3960	435	181	,	,	PUNCT
gs-3960	435	182	and	and	CCONJ
gs-3960	435	183	nad+	nad+	NOUN
gs-3960	435	184	enhancers	enhancer	NOUN
gs-3960	435	185	and	and	CCONJ
gs-3960	435	186	nad+	nad+	PROPN
gs-3960	435	187	boosters	booster	NOUN
gs-3960	435	188	may	may	AUX
gs-3960	435	189	offer	offer	VERB
gs-3960	435	190	disease	disease	NOUN
gs-3960	435	191	-	-	PUNCT
gs-3960	435	192	modifying	modify	VERB
gs-3960	435	193	benefits	benefit	NOUN
gs-3960	435	194	,	,	PUNCT
gs-3960	435	195	potentially	potentially	ADV
gs-3960	435	196	slowing	slow	VERB
gs-3960	435	197	or	or	CCONJ
gs-3960	435	198	halting	halting	ADJ
gs-3960	435	199	neurodegeneration	neurodegeneration	NOUN
gs-3960	435	200	.	.	PUNCT
gs-3960	436	1	however	however	ADV
gs-3960	436	2	,	,	PUNCT
gs-3960	436	3	translating	translate	VERB
gs-3960	436	4	these	these	DET
gs-3960	436	5	findings	finding	NOUN
gs-3960	436	6	into	into	ADP
gs-3960	436	7	clinical	clinical	ADJ
gs-3960	436	8	applications	application	NOUN
gs-3960	436	9	requires	require	VERB
gs-3960	436	10	overcoming	overcome	VERB
gs-3960	436	11	significant	significant	ADJ
gs-3960	436	12	challenges	challenge	NOUN
gs-3960	436	13	,	,	PUNCT
gs-3960	436	14	including	include	VERB
gs-3960	436	15	drug	drug	NOUN
gs-3960	436	16	delivery	delivery	NOUN
gs-3960	436	17	barriers	barrier	NOUN
gs-3960	436	18	and	and	CCONJ
gs-3960	436	19	the	the	DET
gs-3960	436	20	complexity	complexity	NOUN
gs-3960	436	21	of	of	ADP
gs-3960	436	22	mitochondrial	mitochondrial	ADJ
gs-3960	436	23	dysfunction	dysfunction	NOUN
gs-3960	436	24	in	in	ADP
gs-3960	436	25	neurodegeneration	neurodegeneration	NOUN
gs-3960	436	26	.	.	PUNCT
gs-3960	437	1	further	further	ADJ
gs-3960	437	2	clinical	clinical	ADJ
gs-3960	437	3	trials	trial	NOUN
gs-3960	437	4	and	and	CCONJ
gs-3960	437	5	combination	combination	NOUN
gs-3960	437	6	therapy	therapy	NOUN
gs-3960	437	7	approaches	approach	NOUN
gs-3960	437	8	are	be	AUX
gs-3960	437	9	needed	need	VERB
gs-3960	437	10	to	to	PART
gs-3960	437	11	validate	validate	VERB
gs-3960	437	12	their	their	PRON
gs-3960	437	13	efficacy	efficacy	NOUN
gs-3960	437	14	and	and	CCONJ
gs-3960	437	15	establish	establish	VERB
gs-3960	437	16	novel	novel	ADJ
gs-3960	437	17	therapeutic	therapeutic	ADJ
gs-3960	437	18	strategies	strategy	NOUN
gs-3960	437	19	for	for	ADP
gs-3960	437	20	pd	pd	PROPN
gs-3960	437	21	.	.	PUNCT
gs-3960	437	22	ultimately	ultimately	ADV
gs-3960	437	23	,	,	PUNCT
gs-3960	437	24	enhancing	enhance	VERB
gs-3960	437	25	mitochondrial	mitochondrial	ADJ
gs-3960	437	26	function	function	NOUN
gs-3960	437	27	through	through	ADP
gs-3960	437	28	mitophagy	mitophagy	NOUN
gs-3960	437	29	and	and	CCONJ
gs-3960	437	30	nad+	nad+	PROPN
gs-3960	437	31	georgian	georgian	NOUN
gs-3960	437	32	scientists/	scientists/	NUM
gs-3960	437	33	.	.	PUNCT
gs-3960	438	1	7	7	NUM
gs-3960	438	2	n	n	PRON
gs-3960	438	3	3	3	NUM
gs-3960	438	4	,	,	PUNCT
gs-3960	438	5	2025	2025	NUM
gs-3960	438	6	426	426	NUM
gs-3960	438	7	metabolism	metabolism	NOUN
gs-3960	438	8	holds	hold	VERB
gs-3960	438	9	great	great	ADJ
gs-3960	438	10	potential	potential	NOUN
gs-3960	438	11	for	for	ADP
gs-3960	438	12	improving	improve	VERB
gs-3960	438	13	patient	patient	ADJ
gs-3960	438	14	outcomes	outcome	NOUN
gs-3960	438	15	and	and	CCONJ
gs-3960	438	16	advancing	advance	VERB
gs-3960	438	17	pd	pd	PROPN
gs-3960	438	18	treatment	treatment	NOUN
gs-3960	438	19	.	.	PUNCT
gs-3960	439	1	challenges	challenge	NOUN
gs-3960	439	2	and	and	CCONJ
gs-3960	439	3	future	future	ADJ
gs-3960	439	4	directions	direction	NOUN
gs-3960	439	5	despite	despite	SCONJ
gs-3960	439	6	the	the	DET
gs-3960	439	7	promise	promise	NOUN
gs-3960	439	8	of	of	ADP
gs-3960	439	9	targeting	target	VERB
gs-3960	439	10	mitophagy	mitophagy	NOUN
gs-3960	439	11	and	and	CCONJ
gs-3960	439	12	nad+	nad+	PROPN
gs-3960	439	13	metabolism	metabolism	NOUN
gs-3960	439	14	,	,	PUNCT
gs-3960	439	15	several	several	ADJ
gs-3960	439	16	challenges	challenge	NOUN
gs-3960	439	17	remain	remain	VERB
gs-3960	439	18	.	.	PUNCT
gs-3960	440	1	the	the	DET
gs-3960	440	2	blood	blood	NOUN
gs-3960	440	3	-	-	PUNCT
gs-3960	440	4	brain	brain	NOUN
gs-3960	440	5	barrier	barrier	NOUN
gs-3960	440	6	(	(	PUNCT
gs-3960	440	7	bbb	bbb	PROPN
gs-3960	440	8	)	)	PUNCT
gs-3960	440	9	limits	limit	VERB
gs-3960	440	10	the	the	DET
gs-3960	440	11	effective	effective	ADJ
gs-3960	440	12	delivery	delivery	NOUN
gs-3960	440	13	of	of	ADP
gs-3960	440	14	therapeutic	therapeutic	ADJ
gs-3960	440	15	agents	agent	NOUN
gs-3960	440	16	to	to	ADP
gs-3960	440	17	the	the	DET
gs-3960	440	18	central	central	ADJ
gs-3960	440	19	nervous	nervous	ADJ
gs-3960	440	20	system	system	NOUN
gs-3960	440	21	.	.	PUNCT
gs-3960	441	1	advanced	advanced	ADJ
gs-3960	441	2	drug	drug	NOUN
gs-3960	441	3	delivery	delivery	NOUN
gs-3960	441	4	systems	system	NOUN
gs-3960	441	5	,	,	PUNCT
gs-3960	441	6	such	such	ADJ
gs-3960	441	7	as	as	ADP
gs-3960	441	8	mitochondria	mitochondria	NOUN
gs-3960	441	9	-	-	PUNCT
gs-3960	441	10	targeted	target	VERB
gs-3960	441	11	nanoparticles	nanoparticle	NOUN
gs-3960	441	12	,	,	PUNCT
gs-3960	441	13	have	have	AUX
gs-3960	441	14	been	be	AUX
gs-3960	441	15	developed	develop	VERB
gs-3960	441	16	to	to	PART
gs-3960	441	17	improve	improve	VERB
gs-3960	441	18	pharmacokinetics	pharmacokinetic	NOUN
gs-3960	441	19	and	and	CCONJ
gs-3960	441	20	biodistribution	biodistribution	NOUN
gs-3960	441	21	(	(	PUNCT
gs-3960	441	22	chidambaram	chidambaram	PROPN
gs-3960	441	23	et	et	PROPN
gs-3960	441	24	al	al	PROPN
gs-3960	441	25	.	.	PROPN
gs-3960	441	26	,	,	PUNCT
gs-3960	441	27	2020	2020	NUM
gs-3960	441	28	)	)	PUNCT
gs-3960	441	29	.	.	PUNCT
gs-3960	442	1	additionally	additionally	ADV
gs-3960	442	2	,	,	PUNCT
gs-3960	442	3	the	the	DET
gs-3960	442	4	clinical	clinical	ADJ
gs-3960	442	5	relevance	relevance	NOUN
gs-3960	442	6	of	of	ADP
gs-3960	442	7	mitophagy	mitophagy	NOUN
gs-3960	442	8	activators	activator	NOUN
gs-3960	442	9	remains	remain	VERB
gs-3960	442	10	uncertain	uncertain	ADJ
gs-3960	442	11	,	,	PUNCT
gs-3960	442	12	as	as	SCONJ
gs-3960	442	13	their	their	PRON
gs-3960	442	14	effects	effect	NOUN
gs-3960	442	15	in	in	ADP
gs-3960	442	16	cns	cns	NOUN
gs-3960	442	17	models	model	NOUN
gs-3960	442	18	are	be	AUX
gs-3960	442	19	still	still	ADV
gs-3960	442	20	not	not	PART
gs-3960	442	21	well	well	ADV
gs-3960	442	22	understood	understand	VERB
gs-3960	442	23	(	(	PUNCT
gs-3960	442	24	dhar	dhar	PROPN
gs-3960	442	25	et	et	PROPN
gs-3960	442	26	al	al	PROPN
gs-3960	442	27	.	.	PROPN
gs-3960	442	28	,	,	PUNCT
gs-3960	442	29	2024	2024	NUM
gs-3960	442	30	)	)	PUNCT
gs-3960	442	31	.	.	PUNCT
gs-3960	443	1	ongoing	ongoing	ADJ
gs-3960	443	2	clinical	clinical	ADJ
gs-3960	443	3	trials	trial	NOUN
gs-3960	443	4	aim	aim	VERB
gs-3960	443	5	to	to	PART
gs-3960	443	6	assess	assess	VERB
gs-3960	443	7	their	their	PRON
gs-3960	443	8	efficacy	efficacy	NOUN
gs-3960	443	9	,	,	PUNCT
gs-3960	443	10	but	but	CCONJ
gs-3960	443	11	further	far	ADV
gs-3960	443	12	neurodegenerative	neurodegenerative	ADJ
gs-3960	443	13	disorders	disorder	NOUN
gs-3960	443	14	.	.	PUNCT
gs-3960	444	1	the	the	DET
gs-3960	444	2	path	path	NOUN
gs-3960	444	3	forward	forward	ADV
gs-3960	444	4	the	the	DET
gs-3960	444	5	landscape	landscape	NOUN
gs-3960	444	6	of	of	ADP
gs-3960	444	7	mitochondrial	mitochondrial	ADJ
gs-3960	444	8	research	research	NOUN
gs-3960	444	9	in	in	ADP
gs-3960	444	10	parkinson	parkinson	NOUN
gs-3960	444	11	's	's	PART
gs-3960	444	12	disease	disease	NOUN
gs-3960	444	13	has	have	AUX
gs-3960	444	14	expanded	expand	VERB
gs-3960	444	15	dramatically	dramatically	ADV
gs-3960	444	16	in	in	ADP
gs-3960	444	17	recent	recent	ADJ
gs-3960	444	18	years	year	NOUN
gs-3960	444	19	,	,	PUNCT
gs-3960	444	20	revealing	reveal	VERB
gs-3960	444	21	unexpected	unexpected	ADJ
gs-3960	444	22	complexities	complexity	NOUN
gs-3960	444	23	and	and	CCONJ
gs-3960	444	24	therapeutic	therapeutic	ADJ
gs-3960	444	25	opportunities	opportunity	NOUN
gs-3960	444	26	.	.	PUNCT
gs-3960	445	1	what	what	PRON
gs-3960	445	2	began	begin	VERB
gs-3960	445	3	as	as	ADP
gs-3960	445	4	a	a	DET
gs-3960	445	5	simple	simple	ADJ
gs-3960	445	6	energy	energy	NOUN
gs-3960	445	7	deficiency	deficiency	NOUN
gs-3960	445	8	hypothesis	hypothesis	NOUN
gs-3960	445	9	has	have	AUX
gs-3960	445	10	blossomed	blossom	VERB
gs-3960	445	11	into	into	ADP
gs-3960	445	12	a	a	DET
gs-3960	445	13	rich	rich	ADJ
gs-3960	445	14	understanding	understanding	NOUN
gs-3960	445	15	of	of	ADP
gs-3960	445	16	mitochondria	mitochondria	NOUN
gs-3960	445	17	as	as	ADP
gs-3960	445	18	central	central	ADJ
gs-3960	445	19	players	player	NOUN
gs-3960	445	20	in	in	ADP
gs-3960	445	21	virtually	virtually	ADV
gs-3960	445	22	all	all	PRON
gs-3960	445	23	aspects	aspect	NOUN
gs-3960	445	24	of	of	ADP
gs-3960	445	25	neuronal	neuronal	ADJ
gs-3960	445	26	health	health	NOUN
gs-3960	445	27	and	and	CCONJ
gs-3960	445	28	disease	disease	NOUN
gs-3960	445	29	.	.	PUNCT
gs-3960	446	1	as	as	SCONJ
gs-3960	446	2	we	we	PRON
gs-3960	446	3	continue	continue	VERB
gs-3960	446	4	to	to	PART
gs-3960	446	5	unravel	unravel	VERB
gs-3960	446	6	these	these	DET
gs-3960	446	7	complexities	complexity	NOUN
gs-3960	446	8	,	,	PUNCT
gs-3960	446	9	the	the	DET
gs-3960	446	10	promise	promise	NOUN
gs-3960	446	11	of	of	ADP
gs-3960	446	12	meaningful	meaningful	ADJ
gs-3960	446	13	diseasemodifying	diseasemodifying	NOUN
gs-3960	446	14	therapies	therapy	NOUN
gs-3960	446	15	grows	grow	VERB
gs-3960	446	16	stronger	strong	ADJ
gs-3960	446	17	.	.	PUNCT
gs-3960	447	1	the	the	DET
gs-3960	447	2	coming	come	VERB
gs-3960	447	3	decade	decade	NOUN
gs-3960	447	4	will	will	AUX
gs-3960	447	5	likely	likely	ADV
gs-3960	447	6	see	see	VERB
gs-3960	447	7	the	the	DET
gs-3960	447	8	first	first	ADJ
gs-3960	447	9	generation	generation	NOUN
gs-3960	447	10	of	of	ADP
gs-3960	447	11	these	these	DET
gs-3960	447	12	sophisticated	sophisticated	ADJ
gs-3960	447	13	mitochondrial	mitochondrial	ADJ
gs-3960	447	14	-	-	PUNCT
gs-3960	447	15	targeted	target	VERB
gs-3960	447	16	treatments	treatment	NOUN
gs-3960	447	17	enter	enter	VERB
gs-3960	447	18	clinical	clinical	ADJ
gs-3960	447	19	testing	testing	NOUN
gs-3960	447	20	,	,	PUNCT
gs-3960	447	21	offering	offer	VERB
gs-3960	447	22	new	new	ADJ
gs-3960	447	23	hope	hope	NOUN
gs-3960	447	24	for	for	ADP
gs-3960	447	25	altering	alter	VERB
gs-3960	447	26	the	the	DET
gs-3960	447	27	course	course	NOUN
gs-3960	447	28	of	of	ADP
gs-3960	447	29	parkinson	parkinson	NOUN
gs-3960	447	30	's	's	PART
gs-3960	447	31	disease	disease	NOUN
gs-3960	447	32	.	.	PUNCT
gs-3960	448	1	what	what	PRON
gs-3960	448	2	remains	remain	VERB
gs-3960	448	3	certain	certain	ADJ
gs-3960	448	4	is	be	AUX
gs-3960	448	5	that	that	SCONJ
gs-3960	448	6	any	any	DET
gs-3960	448	7	comprehensive	comprehensive	ADJ
gs-3960	448	8	therapeutic	therapeutic	ADJ
gs-3960	448	9	strategy	strategy	NOUN
gs-3960	448	10	for	for	ADP
gs-3960	448	11	parkinson	parkinson	NOUN
gs-3960	448	12	's	's	PART
gs-3960	448	13	must	must	AUX
gs-3960	448	14	address	address	VERB
gs-3960	448	15	the	the	DET
gs-3960	448	16	multifaceted	multifaceted	ADJ
gs-3960	448	17	roles	role	NOUN
gs-3960	448	18	of	of	ADP
gs-3960	448	19	mitochondria	mitochondria	NOUN
gs-3960	448	20	in	in	ADP
gs-3960	448	21	neuronal	neuronal	ADJ
gs-3960	448	22	survival	survival	NOUN
gs-3960	448	23	,	,	PUNCT
gs-3960	448	24	recognizing	recognize	VERB
gs-3960	448	25	these	these	DET
gs-3960	448	26	organelles	organelle	NOUN
gs-3960	448	27	as	as	ADP
gs-3960	448	28	both	both	DET
gs-3960	448	29	victims	victim	NOUN
gs-3960	448	30	and	and	CCONJ
gs-3960	448	31	perpetrators	perpetrator	NOUN
gs-3960	448	32	in	in	ADP
gs-3960	448	33	the	the	DET
gs-3960	448	34	disease	disease	NOUN
gs-3960	448	35	process	process	NOUN
gs-3960	448	36	.	.	PUNCT
gs-3960	449	1	this	this	DET
gs-3960	449	2	ever	ever	ADV
gs-3960	449	3	-	-	PUNCT
gs-3960	449	4	deepening	deepen	VERB
gs-3960	449	5	understanding	understanding	NOUN
gs-3960	449	6	of	of	ADP
gs-3960	449	7	mitochondrial	mitochondrial	ADJ
gs-3960	449	8	biology	biology	NOUN
gs-3960	449	9	in	in	ADP
gs-3960	449	10	parkinson	parkinson	NOUN
gs-3960	449	11	's	's	PART
gs-3960	449	12	disease	disease	NOUN
gs-3960	449	13	continues	continue	VERB
gs-3960	449	14	to	to	PART
gs-3960	449	15	challenge	challenge	VERB
gs-3960	449	16	and	and	CCONJ
gs-3960	449	17	surprise	surprise	NOUN
gs-3960	449	18	researchers	researcher	NOUN
gs-3960	449	19	,	,	PUNCT
gs-3960	449	20	with	with	ADP
gs-3960	449	21	each	each	DET
gs-3960	449	22	new	new	ADJ
gs-3960	449	23	discovery	discovery	NOUN
gs-3960	449	24	revealing	reveal	VERB
gs-3960	449	25	additional	additional	ADJ
gs-3960	449	26	layers	layer	NOUN
gs-3960	449	27	of	of	ADP
gs-3960	449	28	complexity	complexity	NOUN
gs-3960	449	29	in	in	ADP
gs-3960	449	30	the	the	DET
gs-3960	449	31	relationship	relationship	NOUN
gs-3960	449	32	between	between	ADP
gs-3960	449	33	mitochondrial	mitochondrial	ADJ
gs-3960	449	34	health	health	NOUN
gs-3960	449	35	and	and	CCONJ
gs-3960	449	36	neuronal	neuronal	ADJ
gs-3960	449	37	survival	survival	NOUN
gs-3960	449	38	.	.	PUNCT
gs-3960	450	1	the	the	DET
gs-3960	450	2	field	field	NOUN
gs-3960	450	3	has	have	AUX
gs-3960	450	4	moved	move	VERB
gs-3960	450	5	far	far	ADV
gs-3960	450	6	beyond	beyond	ADP
gs-3960	450	7	simplistic	simplistic	ADJ
gs-3960	450	8	notions	notion	NOUN
gs-3960	450	9	of	of	ADP
gs-3960	450	10	energy	energy	NOUN
gs-3960	450	11	failure	failure	NOUN
gs-3960	450	12	to	to	PART
gs-3960	450	13	appreciate	appreciate	VERB
gs-3960	450	14	mitochondria	mitochondria	NOUN
gs-3960	450	15	as	as	ADP
gs-3960	450	16	sophisticated	sophisticated	ADJ
gs-3960	450	17	signaling	signal	VERB
gs-3960	450	18	hubs	hub	NOUN
gs-3960	450	19	that	that	PRON
gs-3960	450	20	integrate	integrate	VERB
gs-3960	450	21	metabolic	metabolic	NOUN
gs-3960	450	22	,	,	PUNCT
gs-3960	450	23	proteostatic	proteostatic	NOUN
gs-3960	450	24	,	,	PUNCT
gs-3960	450	25	and	and	CCONJ
gs-3960	450	26	inflammatory	inflammatory	ADJ
gs-3960	450	27	information	information	NOUN
gs-3960	450	28	.	.	PUNCT
gs-3960	451	1	this	this	DET
gs-3960	451	2	paradigm	paradigm	NOUN
gs-3960	451	3	shift	shift	NOUN
gs-3960	451	4	continues	continue	VERB
gs-3960	451	5	to	to	PART
gs-3960	451	6	open	open	VERB
gs-3960	451	7	new	new	ADJ
gs-3960	451	8	avenues	avenue	NOUN
gs-3960	451	9	for	for	ADP
gs-3960	451	10	therapeutic	therapeutic	ADJ
gs-3960	451	11	intervention	intervention	NOUN
gs-3960	451	12	while	while	SCONJ
gs-3960	451	13	reminding	remind	VERB
gs-3960	451	14	us	we	PRON
gs-3960	451	15	of	of	ADP
gs-3960	451	16	the	the	DET
gs-3960	451	17	remarkable	remarkable	ADJ
gs-3960	451	18	adaptability	adaptability	NOUN
gs-3960	451	19	and	and	CCONJ
gs-3960	451	20	vulnerability	vulnerability	NOUN
gs-3960	451	21	of	of	ADP
gs-3960	451	22	the	the	DET
gs-3960	451	23	neuronal	neuronal	ADJ
gs-3960	451	24	networks	network	NOUN
gs-3960	451	25	affected	affect	VERB
gs-3960	451	26	in	in	ADP
gs-3960	451	27	parkinson	parkinson	NOUN
gs-3960	451	28	's	's	PART
gs-3960	451	29	disease	disease	NOUN
gs-3960	451	30	.	.	PUNCT
gs-3960	452	1	this	this	DET
gs-3960	452	2	comprehensive	comprehensive	ADJ
gs-3960	452	3	investigation	investigation	NOUN
gs-3960	452	4	establishes	establish	VERB
gs-3960	452	5	mitochondrial	mitochondrial	ADJ
gs-3960	452	6	dysfunction	dysfunction	NOUN
gs-3960	452	7	as	as	ADP
gs-3960	452	8	the	the	DET
gs-3960	452	9	central	central	ADJ
gs-3960	452	10	node	node	NOUN
gs-3960	452	11	in	in	ADP
gs-3960	452	12	parkinson	parkinson	NOUN
gs-3960	452	13	's	's	PART
gs-3960	452	14	pathogenesis	pathogenesis	NOUN
gs-3960	452	15	,	,	PUNCT
gs-3960	452	16	with	with	ADP
gs-3960	452	17	mitophagy	mitophagy	NOUN
gs-3960	452	18	and	and	CCONJ
gs-3960	452	19	nad+	nad+	PROPN
gs-3960	452	20	metabolism	metabolism	NOUN
gs-3960	452	21	representing	represent	VERB
gs-3960	452	22	interdependent	interdependent	ADJ
gs-3960	452	23	pathways	pathway	NOUN
gs-3960	452	24	that	that	PRON
gs-3960	452	25	can	can	AUX
gs-3960	452	26	be	be	AUX
gs-3960	452	27	therapeutically	therapeutically	ADV
gs-3960	452	28	targeted	target	VERB
gs-3960	452	29	.	.	PUNCT
gs-3960	453	1	while	while	SCONJ
gs-3960	453	2	significant	significant	ADJ
gs-3960	453	3	challenges	challenge	NOUN
gs-3960	453	4	remain	remain	VERB
gs-3960	453	5	in	in	ADP
gs-3960	453	6	drug	drug	NOUN
gs-3960	453	7	delivery	delivery	NOUN
gs-3960	453	8	and	and	CCONJ
gs-3960	453	9	patient	patient	ADJ
gs-3960	453	10	stratification	stratification	NOUN
gs-3960	453	11	,	,	PUNCT
gs-3960	453	12	the	the	DET
gs-3960	453	13	convergence	convergence	NOUN
gs-3960	453	14	of	of	ADP
gs-3960	453	15	mechanistic	mechanistic	ADJ
gs-3960	453	16	understanding	understanding	NOUN
gs-3960	453	17	and	and	CCONJ
gs-3960	453	18	technological	technological	ADJ
gs-3960	453	19	innovation	innovation	NOUN
gs-3960	453	20	positions	position	NOUN
gs-3960	453	21	mitochondrial	mitochondrial	ADJ
gs-3960	453	22	therapy	therapy	NOUN
gs-3960	453	23	as	as	ADP
gs-3960	453	24	the	the	DET
gs-3960	453	25	most	most	ADV
gs-3960	453	26	promising	promising	ADJ
gs-3960	453	27	disease	disease	NOUN
gs-3960	453	28	-	-	PUNCT
gs-3960	453	29	modifying	modify	VERB
gs-3960	453	30	strategy	strategy	NOUN
gs-3960	453	31	for	for	ADP
gs-3960	453	32	parkinson	parkinson	NOUN
gs-3960	453	33	's	's	PART
gs-3960	453	34	disease	disease	NOUN
gs-3960	453	35	on	on	ADP
gs-3960	453	36	the	the	DET
gs-3960	453	37	georgian	georgian	NOUN
gs-3960	453	38	scientists/	scientists/	NUM
gs-3960	453	39	.	.	PUNCT
gs-3960	454	1	7	7	NUM
gs-3960	454	2	n	n	PRON
gs-3960	454	3	3	3	NUM
gs-3960	454	4	,	,	PUNCT
gs-3960	454	5	2025	2025	NUM
gs-3960	454	6	427	427	NUM
gs-3960	454	7	horizon	horizon	NOUN
gs-3960	454	8	.	.	PUNCT
gs-3960	455	1	the	the	DET
gs-3960	455	2	coming	come	VERB
gs-3960	455	3	decade	decade	NOUN
gs-3960	455	4	will	will	AUX
gs-3960	455	5	likely	likely	ADV
gs-3960	455	6	see	see	VERB
gs-3960	455	7	the	the	DET
gs-3960	455	8	first	first	ADJ
gs-3960	455	9	generation	generation	NOUN
gs-3960	455	10	of	of	ADP
gs-3960	455	11	these	these	DET
gs-3960	455	12	therapies	therapy	NOUN
gs-3960	455	13	transition	transition	NOUN
gs-3960	455	14	from	from	ADP
gs-3960	455	15	:	:	PUNCT
gs-3960	455	16	future	future	ADJ
gs-3960	455	17	investigations	investigation	NOUN
gs-3960	455	18	should	should	AUX
gs-3960	455	19	focus	focus	VERB
gs-3960	455	20	on	on	ADP
gs-3960	455	21	elucidating	elucidate	VERB
gs-3960	455	22	the	the	DET
gs-3960	455	23	molecular	molecular	ADJ
gs-3960	455	24	details	detail	NOUN
gs-3960	455	25	of	of	ADP
gs-3960	455	26	newly	newly	ADV
gs-3960	455	27	discovered	discover	VERB
gs-3960	455	28	mitochondrial	mitochondrial	ADJ
gs-3960	455	29	processes	process	NOUN
gs-3960	455	30	,	,	PUNCT
gs-3960	455	31	including	include	VERB
gs-3960	455	32	the	the	DET
gs-3960	455	33	mitochondrial	mitochondrial	ADJ
gs-3960	455	34	epitranscriptome	epitranscriptome	NOUN
gs-3960	455	35	,	,	PUNCT
gs-3960	455	36	interorganelle	interorganelle	ADJ
gs-3960	455	37	communication	communication	NOUN
gs-3960	455	38	networks	network	NOUN
gs-3960	455	39	,	,	PUNCT
gs-3960	455	40	and	and	CCONJ
gs-3960	455	41	activity	activity	NOUN
gs-3960	455	42	-	-	PUNCT
gs-3960	455	43	dependent	dependent	ADJ
gs-3960	455	44	plasticity	plasticity	NOUN
gs-3960	455	45	mechanisms	mechanism	NOUN
gs-3960	455	46	.	.	PUNCT
gs-3960	456	1	special	special	ADJ
gs-3960	456	2	attention	attention	NOUN
gs-3960	456	3	should	should	AUX
gs-3960	456	4	be	be	AUX
gs-3960	456	5	given	give	VERB
gs-3960	456	6	to	to	ADP
gs-3960	456	7	understanding	understand	VERB
gs-3960	456	8	how	how	SCONJ
gs-3960	456	9	these	these	DET
gs-3960	456	10	pathways	pathway	NOUN
gs-3960	456	11	intersect	intersect	ADJ
gs-3960	456	12	with	with	ADP
gs-3960	456	13	known	know	VERB
gs-3960	456	14	parkinson	parkinson	NOUN
gs-3960	456	15	's	's	PART
gs-3960	456	16	disease	disease	NOUN
gs-3960	456	17	risk	risk	NOUN
gs-3960	456	18	factors	factor	NOUN
gs-3960	456	19	and	and	CCONJ
gs-3960	456	20	pathological	pathological	ADJ
gs-3960	456	21	processes	process	NOUN
gs-3960	456	22	.	.	PUNCT
gs-3960	457	1	:	:	PUNCT
gs-3960	457	2	there	there	PRON
gs-3960	457	3	is	be	VERB
gs-3960	457	4	a	a	DET
gs-3960	457	5	critical	critical	ADJ
gs-3960	457	6	need	need	NOUN
gs-3960	457	7	for	for	ADP
gs-3960	457	8	more	more	ADV
gs-3960	457	9	physiologically	physiologically	ADV
gs-3960	457	10	relevant	relevant	ADJ
gs-3960	457	11	model	model	NOUN
gs-3960	457	12	systems	system	NOUN
gs-3960	457	13	that	that	PRON
gs-3960	457	14	better	well	ADV
gs-3960	457	15	recapitulate	recapitulate	VERB
gs-3960	457	16	human	human	ADJ
gs-3960	457	17	mitochondrial	mitochondrial	ADJ
gs-3960	457	18	biology	biology	NOUN
gs-3960	457	19	in	in	ADP
gs-3960	457	20	parkinson	parkinson	NOUN
gs-3960	457	21	's	's	PART
gs-3960	457	22	disease	disease	NOUN
gs-3960	457	23	.	.	PUNCT
gs-3960	458	1	this	this	PRON
gs-3960	458	2	includes	include	VERB
gs-3960	458	3	optimizing	optimize	VERB
gs-3960	458	4	3d	3d	NUM
gs-3960	458	5	organoid	organoid	PROPN
gs-3960	458	6	cultures	culture	NOUN
gs-3960	458	7	with	with	ADP
gs-3960	458	8	proper	proper	ADJ
gs-3960	458	9	neuronal	neuronal	ADJ
gs-3960	458	10	-	-	PUNCT
gs-3960	458	11	glial	glial	ADJ
gs-3960	458	12	interactions	interaction	NOUN
gs-3960	458	13	,	,	PUNCT
gs-3960	458	14	developing	develop	VERB
gs-3960	458	15	microfluidic	microfluidic	ADJ
gs-3960	458	16	platforms	platform	NOUN
gs-3960	458	17	to	to	PART
gs-3960	458	18	study	study	VERB
gs-3960	458	19	axonal	axonal	ADJ
gs-3960	458	20	mitochondrial	mitochondrial	ADJ
gs-3960	458	21	transport	transport	NOUN
gs-3960	458	22	,	,	PUNCT
gs-3960	458	23	and	and	CCONJ
gs-3960	458	24	creating	create	VERB
gs-3960	458	25	humanized	humanize	VERB
gs-3960	458	26	animal	animal	NOUN
gs-3960	458	27	models	model	NOUN
gs-3960	458	28	that	that	PRON
gs-3960	458	29	incorporate	incorporate	VERB
gs-3960	458	30	patient	patient	NOUN
gs-3960	458	31	-	-	PUNCT
gs-3960	458	32	derived	derive	VERB
gs-3960	458	33	genetic	genetic	ADJ
gs-3960	458	34	variants	variant	NOUN
gs-3960	458	35	in	in	ADP
gs-3960	458	36	appropriate	appropriate	ADJ
gs-3960	458	37	cellular	cellular	ADJ
gs-3960	458	38	contexts	contexts	NOUN
gs-3960	458	39	.	.	PUNCT
gs-3960	459	1	:	:	PUNCT
gs-3960	459	2	comprehensive	comprehensive	ADJ
gs-3960	459	3	profiling	profiling	NOUN
gs-3960	459	4	of	of	ADP
gs-3960	459	5	mitochondrial	mitochondrial	ADJ
gs-3960	459	6	changes	change	NOUN
gs-3960	459	7	across	across	ADP
gs-3960	459	8	different	different	ADJ
gs-3960	459	9	disease	disease	NOUN
gs-3960	459	10	stages	stage	NOUN
gs-3960	459	11	using	use	VERB
gs-3960	459	12	integrated	integrated	ADJ
gs-3960	459	13	genomics	genomic	NOUN
gs-3960	459	14	,	,	PUNCT
gs-3960	459	15	proteomics	proteomic	NOUN
gs-3960	459	16	,	,	PUNCT
gs-3960	459	17	metabolomics	metabolomic	NOUN
gs-3960	459	18	,	,	PUNCT
gs-3960	459	19	and	and	CCONJ
gs-3960	459	20	lipidomics	lipidomic	NOUN
gs-3960	459	21	should	should	AUX
gs-3960	459	22	be	be	AUX
gs-3960	459	23	prioritized	prioritize	VERB
gs-3960	459	24	.	.	PUNCT
gs-3960	460	1	these	these	DET
gs-3960	460	2	efforts	effort	NOUN
gs-3960	460	3	should	should	AUX
gs-3960	460	4	specifically	specifically	ADV
gs-3960	460	5	focus	focus	VERB
gs-3960	460	6	on	on	ADP
gs-3960	460	7	vulnerable	vulnerable	ADJ
gs-3960	460	8	neuronal	neuronal	ADJ
gs-3960	460	9	populations	population	NOUN
gs-3960	460	10	and	and	CCONJ
gs-3960	460	11	compare	compare	VERB
gs-3960	460	12	them	they	PRON
gs-3960	460	13	to	to	ADP
gs-3960	460	14	resistant	resistant	ADJ
gs-3960	460	15	cell	cell	NOUN
gs-3960	460	16	types	type	NOUN
gs-3960	460	17	to	to	PART
gs-3960	460	18	identify	identify	VERB
gs-3960	460	19	protective	protective	ADJ
gs-3960	460	20	mechanisms	mechanism	NOUN
gs-3960	460	21	.	.	PUNCT
gs-3960	461	1	bench	bench	VERB
gs-3960	461	2	to	to	ADP
gs-3960	461	3	bedside	bedside	NOUN
gs-3960	461	4	,	,	PUNCT
gs-3960	461	5	potentially	potentially	ADV
gs-3960	461	6	revolutionizing	revolutionize	VERB
gs-3960	461	7	parkinson	parkinson	NOUN
gs-3960	461	8	's	's	PART
gs-3960	461	9	treatment	treatment	NOUN
gs-3960	461	10	.	.	PUNCT
gs-3960	462	1	suggestions	suggestion	NOUN
gs-3960	462	2	for	for	ADP
gs-3960	462	3	advancing	advance	VERB
gs-3960	462	4	research	research	NOUN
gs-3960	462	5	and	and	CCONJ
gs-3960	462	6	clinical	clinical	ADJ
gs-3960	462	7	translation	translation	NOUN
gs-3960	462	8	in	in	ADP
gs-3960	462	9	mitochondrial	mitochondrial	ADJ
gs-3960	462	10	dysfunction	dysfunction	NOUN
gs-3960	462	11	and	and	CCONJ
gs-3960	462	12	parkinson	parkinson	NOUN
gs-3960	462	13	's	's	PART
gs-3960	462	14	diseasefor	diseasefor	ADP
gs-3960	462	15	basic	basic	ADJ
gs-3960	462	16	and	and	CCONJ
gs-3960	462	17	translational	translational	ADJ
gs-3960	462	18	research	research	NOUN
gs-3960	462	19	:	:	PUNCT
gs-3960	462	20	for	for	ADP
gs-3960	462	21	therapeutic	therapeutic	ADJ
gs-3960	462	22	development	development	NOUN
gs-3960	462	23	:	:	PUNCT
gs-3960	462	24	:	:	PUNCT
gs-3960	462	25	given	give	VERB
gs-3960	462	26	the	the	DET
gs-3960	462	27	interconnected	interconnected	ADJ
gs-3960	462	28	nature	nature	NOUN
gs-3960	462	29	of	of	ADP
gs-3960	462	30	mitochondrial	mitochondrial	ADJ
gs-3960	462	31	dysfunction	dysfunction	NOUN
gs-3960	462	32	,	,	PUNCT
gs-3960	462	33	therapeutic	therapeutic	ADJ
gs-3960	462	34	strategies	strategy	NOUN
gs-3960	462	35	should	should	AUX
gs-3960	462	36	simultaneously	simultaneously	ADV
gs-3960	462	37	address	address	VERB
gs-3960	462	38	multiple	multiple	ADJ
gs-3960	462	39	aspects	aspect	NOUN
gs-3960	462	40	such	such	ADJ
gs-3960	462	41	as	as	ADP
gs-3960	462	42	combining	combine	VERB
gs-3960	462	43	mitophagy	mitophagy	ADJ
gs-3960	462	44	enhancers	enhancer	NOUN
gs-3960	462	45	with	with	ADP
gs-3960	462	46	nad+	nad+	PROPN
gs-3960	462	47	boosters	booster	NOUN
gs-3960	462	48	,	,	PUNCT
gs-3960	462	49	or	or	CCONJ
gs-3960	462	50	mitochondrial	mitochondrial	ADJ
gs-3960	462	51	antioxidants	antioxidant	NOUN
gs-3960	462	52	with	with	ADP
gs-3960	462	53	protein	protein	NOUN
gs-3960	462	54	import	import	NOUN
gs-3960	462	55	stabilizers	stabilizer	NOUN
gs-3960	462	56	.	.	PUNCT
gs-3960	463	1	preclinical	preclinical	ADJ
gs-3960	463	2	studies	study	NOUN
gs-3960	463	3	should	should	AUX
gs-3960	463	4	systematically	systematically	ADV
gs-3960	463	5	evaluate	evaluate	VERB
gs-3960	463	6	optimal	optimal	ADJ
gs-3960	463	7	combinations	combination	NOUN
gs-3960	463	8	and	and	CCONJ
gs-3960	463	9	sequencing	sequencing	NOUN
gs-3960	463	10	of	of	ADP
gs-3960	463	11	interventions	intervention	NOUN
gs-3960	463	12	.	.	PUNCT
gs-3960	464	1	:	:	PUNCT
gs-3960	464	2	investment	investment	NOUN
gs-3960	464	3	in	in	ADP
gs-3960	464	4	novel	novel	ADJ
gs-3960	464	5	drug	drug	NOUN
gs-3960	464	6	delivery	delivery	NOUN
gs-3960	464	7	technologies	technology	NOUN
gs-3960	464	8	is	be	AUX
gs-3960	464	9	crucial	crucial	ADJ
gs-3960	464	10	to	to	PART
gs-3960	464	11	overcome	overcome	VERB
gs-3960	464	12	current	current	ADJ
gs-3960	464	13	limitations	limitation	NOUN
gs-3960	464	14	in	in	ADP
gs-3960	464	15	blood	blood	NOUN
gs-3960	464	16	-	-	PUNCT
gs-3960	464	17	brain	brain	NOUN
gs-3960	464	18	barrier	barrier	NOUN
gs-3960	464	19	penetration	penetration	NOUN
gs-3960	464	20	and	and	CCONJ
gs-3960	464	21	mitochondrial	mitochondrial	ADJ
gs-3960	464	22	-	-	PUNCT
gs-3960	464	23	specific	specific	ADJ
gs-3960	464	24	targeting	targeting	NOUN
gs-3960	464	25	.	.	PUNCT
gs-3960	465	1	this	this	PRON
gs-3960	465	2	includes	include	VERB
gs-3960	465	3	advancing	advance	VERB
gs-3960	465	4	mitochondrial	mitochondrial	ADJ
gs-3960	465	5	-	-	PUNCT
gs-3960	465	6	targeted	target	VERB
gs-3960	465	7	nanoparticles	nanoparticle	NOUN
gs-3960	465	8	,	,	PUNCT
gs-3960	465	9	viral	viral	ADJ
gs-3960	465	10	vectors	vector	NOUN
gs-3960	465	11	with	with	ADP
gs-3960	465	12	tropism	tropism	NOUN
gs-3960	465	13	for	for	ADP
gs-3960	465	14	dopaminergic	dopaminergic	ADJ
gs-3960	465	15	neurons	neuron	NOUN
gs-3960	465	16	,	,	PUNCT
gs-3960	465	17	and	and	CCONJ
gs-3960	465	18	novel	novel	ADJ
gs-3960	465	19	conjugates	conjugate	NOUN
gs-3960	465	20	that	that	PRON
gs-3960	465	21	exploit	exploit	VERB
gs-3960	465	22	mitochondrial	mitochondrial	ADJ
gs-3960	465	23	import	import	NOUN
gs-3960	465	24	machinery	machinery	NOUN
gs-3960	465	25	.	.	PUNCT
gs-3960	466	1	:	:	PUNCT
gs-3960	466	2	there	there	PRON
gs-3960	466	3	is	be	VERB
gs-3960	466	4	an	an	DET
gs-3960	466	5	urgent	urgent	ADJ
gs-3960	466	6	need	need	NOUN
gs-3960	466	7	to	to	PART
gs-3960	466	8	identify	identify	VERB
gs-3960	466	9	and	and	CCONJ
gs-3960	466	10	validate	validate	VERB
gs-3960	466	11	biomarkers	biomarker	NOUN
gs-3960	466	12	that	that	PRON
gs-3960	466	13	can	can	AUX
gs-3960	466	14	accurately	accurately	ADV
gs-3960	466	15	assess	assess	VERB
gs-3960	466	16	mitochondrial	mitochondrial	ADJ
gs-3960	466	17	function	function	NOUN
gs-3960	466	18	in	in	ADP
gs-3960	466	19	patients	patient	NOUN
gs-3960	466	20	,	,	PUNCT
gs-3960	466	21	stratify	stratify	VERB
gs-3960	466	22	patient	patient	ADJ
gs-3960	466	23	subgroups	subgroup	NOUN
gs-3960	466	24	,	,	PUNCT
gs-3960	466	25	and	and	CCONJ
gs-3960	466	26	monitor	monitor	VERB
gs-3960	466	27	therapeutic	therapeutic	ADJ
gs-3960	466	28	response	response	NOUN
gs-3960	466	29	.	.	PUNCT
gs-3960	467	1	this	this	PRON
gs-3960	467	2	should	should	AUX
gs-3960	467	3	include	include	VERB
gs-3960	467	4	both	both	DET
gs-3960	467	5	imaging	image	VERB
gs-3960	467	6	biomarkers	biomarker	NOUN
gs-3960	467	7	and	and	CCONJ
gs-3960	467	8	fluid	fluid	NOUN
gs-3960	467	9	-	-	PUNCT
gs-3960	467	10	based	base	VERB
gs-3960	467	11	markers	marker	NOUN
gs-3960	467	12	reflecting	reflect	VERB
gs-3960	467	13	different	different	ADJ
gs-3960	467	14	aspects	aspect	NOUN
gs-3960	467	15	of	of	ADP
gs-3960	467	16	mitochondrial	mitochondrial	ADJ
gs-3960	467	17	health	health	NOUN
gs-3960	467	18	.	.	PUNCT
gs-3960	468	1	georgian	georgian	NOUN
gs-3960	468	2	scientists/	scientists/	NUM
gs-3960	468	3	.	.	PUNCT
gs-3960	469	1	7	7	NUM
gs-3960	469	2	n	n	PRON
gs-3960	469	3	3	3	NUM
gs-3960	469	4	,	,	PUNCT
gs-3960	469	5	2025	2025	NUM
gs-3960	469	6	428	428	NUM
gs-3960	469	7	for	for	ADP
gs-3960	469	8	clinical	clinical	ADJ
gs-3960	469	9	translation	translation	NOUN
gs-3960	469	10	:	:	PUNCT
gs-3960	469	11	:	:	PUNCT
gs-3960	469	12	future	future	ADJ
gs-3960	469	13	clinical	clinical	ADJ
gs-3960	469	14	trials	trial	NOUN
gs-3960	469	15	should	should	AUX
gs-3960	469	16	incorporate	incorporate	VERB
gs-3960	469	17	adaptive	adaptive	ADJ
gs-3960	469	18	designs	design	NOUN
gs-3960	469	19	that	that	PRON
gs-3960	469	20	allow	allow	VERB
gs-3960	469	21	for	for	ADP
gs-3960	469	22	testing	test	VERB
gs-3960	469	23	multiple	multiple	ADJ
gs-3960	469	24	mitochondrial	mitochondrial	ADJ
gs-3960	469	25	-	-	PUNCT
gs-3960	469	26	targeted	target	VERB
gs-3960	469	27	interventions	intervention	NOUN
gs-3960	469	28	simultaneously	simultaneously	ADV
gs-3960	469	29	.	.	PUNCT
gs-3960	470	1	trials	trial	NOUN
gs-3960	470	2	should	should	AUX
gs-3960	470	3	include	include	VERB
gs-3960	470	4	comprehensive	comprehensive	ADJ
gs-3960	470	5	mitochondrial	mitochondrial	ADJ
gs-3960	470	6	functional	functional	ADJ
gs-3960	470	7	assessments	assessment	NOUN
gs-3960	470	8	and	and	CCONJ
gs-3960	470	9	consider	consider	VERB
gs-3960	470	10	enrichment	enrichment	NOUN
gs-3960	470	11	strategies	strategy	NOUN
gs-3960	470	12	based	base	VERB
gs-3960	470	13	on	on	ADP
gs-3960	470	14	mitochondrial	mitochondrial	ADJ
gs-3960	470	15	dysfunction	dysfunction	NOUN
gs-3960	470	16	subtypes	subtype	NOUN
gs-3960	470	17	.	.	PUNCT
gs-3960	471	1	:	:	PUNCT
gs-3960	471	2	develop	develop	VERB
gs-3960	471	3	consensus	consensus	NOUN
gs-3960	471	4	guidelines	guideline	NOUN
gs-3960	471	5	for	for	ADP
gs-3960	471	6	evaluating	evaluate	VERB
gs-3960	471	7	mitochondrial	mitochondrial	ADJ
gs-3960	471	8	function	function	NOUN
gs-3960	471	9	in	in	ADP
gs-3960	471	10	clinical	clinical	ADJ
gs-3960	471	11	samples	sample	NOUN
gs-3960	471	12	,	,	PUNCT
gs-3960	471	13	including	include	VERB
gs-3960	471	14	standardized	standardized	ADJ
gs-3960	471	15	protocols	protocol	NOUN
gs-3960	471	16	for	for	ADP
gs-3960	471	17	mitochondrial	mitochondrial	ADJ
gs-3960	471	18	respiration	respiration	NOUN
gs-3960	471	19	assays	assay	NOUN
gs-3960	471	20	,	,	PUNCT
gs-3960	471	21	ros	ros	PROPN
gs-3960	471	22	measurement	measurement	NOUN
gs-3960	471	23	,	,	PUNCT
gs-3960	471	24	and	and	CCONJ
gs-3960	471	25	quality	quality	NOUN
gs-3960	471	26	control	control	NOUN
gs-3960	471	27	pathway	pathway	NOUN
gs-3960	471	28	assessment	assessment	NOUN
gs-3960	471	29	in	in	ADP
gs-3960	471	30	patient	patient	NOUN
gs-3960	471	31	-	-	PUNCT
gs-3960	471	32	derived	derive	VERB
gs-3960	471	33	cells	cell	NOUN
gs-3960	471	34	.	.	PUNCT
gs-3960	472	1	:	:	PUNCT
gs-3960	472	2	encourage	encourage	VERB
gs-3960	472	3	the	the	DET
gs-3960	472	4	formation	formation	NOUN
gs-3960	472	5	of	of	ADP
gs-3960	472	6	specialized	specialized	ADJ
gs-3960	472	7	clinical	clinical	ADJ
gs-3960	472	8	-	-	PUNCT
gs-3960	472	9	research	research	NOUN
gs-3960	472	10	teams	team	NOUN
gs-3960	472	11	combining	combine	VERB
gs-3960	472	12	movement	movement	NOUN
gs-3960	472	13	disorder	disorder	NOUN
gs-3960	472	14	specialists	specialist	NOUN
gs-3960	472	15	,	,	PUNCT
gs-3960	472	16	mitochondrial	mitochondrial	ADJ
gs-3960	472	17	biologists	biologist	NOUN
gs-3960	472	18	,	,	PUNCT
gs-3960	472	19	metabolomics	metabolomic	NOUN
gs-3960	472	20	experts	expert	NOUN
gs-3960	472	21	,	,	PUNCT
gs-3960	472	22	and	and	CCONJ
gs-3960	472	23	therapeutic	therapeutic	ADJ
gs-3960	472	24	developers	developer	NOUN
gs-3960	472	25	to	to	PART
gs-3960	472	26	accelerate	accelerate	VERB
gs-3960	472	27	translational	translational	ADJ
gs-3960	472	28	progress	progress	NOUN
gs-3960	472	29	.	.	PUNCT
gs-3960	473	1	for	for	ADP
gs-3960	473	2	patient	patient	ADJ
gs-3960	473	3	care	care	NOUN
gs-3960	473	4	and	and	CCONJ
gs-3960	473	5	public	public	ADJ
gs-3960	473	6	health	health	NOUN
gs-3960	473	7	:	:	PUNCT
gs-3960	473	8	:	:	PUNCT
gs-3960	473	9	develop	develop	VERB
gs-3960	473	10	clinical	clinical	ADJ
gs-3960	473	11	protocols	protocol	NOUN
gs-3960	473	12	for	for	ADP
gs-3960	473	13	regular	regular	ADJ
gs-3960	473	14	assessment	assessment	NOUN
gs-3960	473	15	of	of	ADP
gs-3960	473	16	mitochondrial	mitochondrial	ADJ
gs-3960	473	17	health	health	NOUN
gs-3960	473	18	in	in	ADP
gs-3960	473	19	at	at	ADP
gs-3960	473	20	-	-	PUNCT
gs-3960	473	21	risk	risk	NOUN
gs-3960	473	22	populations	population	NOUN
gs-3960	473	23	and	and	CCONJ
gs-3960	473	24	early	early	ADJ
gs-3960	473	25	-	-	PUNCT
gs-3960	473	26	stage	stage	NOUN
gs-3960	473	27	parkinson	parkinson	NOUN
gs-3960	473	28	's	's	PART
gs-3960	473	29	patients	patient	NOUN
gs-3960	473	30	,	,	PUNCT
gs-3960	473	31	potentially	potentially	ADV
gs-3960	473	32	including	include	VERB
gs-3960	473	33	peripheral	peripheral	ADJ
gs-3960	473	34	blood	blood	NOUN
gs-3960	473	35	cell	cell	NOUN
gs-3960	473	36	assays	assay	NOUN
gs-3960	473	37	or	or	CCONJ
gs-3960	473	38	non	non	ADJ
gs-3960	473	39	-	-	ADJ
gs-3960	473	40	invasive	invasive	ADJ
gs-3960	473	41	imaging	imaging	NOUN
gs-3960	473	42	markers	marker	NOUN
gs-3960	473	43	.	.	PUNCT
gs-3960	474	1	:	:	PUNCT
gs-3960	474	2	create	create	VERB
gs-3960	474	3	evidence	evidence	NOUN
gs-3960	474	4	-	-	PUNCT
gs-3960	474	5	based	base	VERB
gs-3960	474	6	guidelines	guideline	NOUN
gs-3960	474	7	for	for	ADP
gs-3960	474	8	exercise	exercise	NOUN
gs-3960	474	9	regimens	regimen	NOUN
gs-3960	474	10	,	,	PUNCT
gs-3960	474	11	dietary	dietary	ADJ
gs-3960	474	12	approaches	approach	NOUN
gs-3960	474	13	,	,	PUNCT
gs-3960	474	14	and	and	CCONJ
gs-3960	474	15	stress	stress	NOUN
gs-3960	474	16	reduction	reduction	NOUN
gs-3960	474	17	techniques	technique	NOUN
gs-3960	474	18	that	that	PRON
gs-3960	474	19	support	support	VERB
gs-3960	474	20	mitochondrial	mitochondrial	ADJ
gs-3960	474	21	health	health	NOUN
gs-3960	474	22	in	in	ADP
gs-3960	474	23	parkinson	parkinson	NOUN
gs-3960	474	24	's	's	PART
gs-3960	474	25	patients	patient	NOUN
gs-3960	474	26	,	,	PUNCT
gs-3960	474	27	with	with	ADP
gs-3960	474	28	proper	proper	ADJ
gs-3960	474	29	monitoring	monitoring	NOUN
gs-3960	474	30	of	of	ADP
gs-3960	474	31	their	their	PRON
gs-3960	474	32	effects	effect	NOUN
gs-3960	474	33	on	on	ADP
gs-3960	474	34	disease	disease	NOUN
gs-3960	474	35	progression	progression	NOUN
gs-3960	474	36	.	.	PUNCT
gs-3960	475	1	:	:	PUNCT
gs-3960	475	2	develop	develop	VERB
gs-3960	475	3	continuing	continue	VERB
gs-3960	475	4	medical	medical	ADJ
gs-3960	475	5	education	education	NOUN
gs-3960	475	6	programs	program	NOUN
gs-3960	475	7	to	to	PART
gs-3960	475	8	update	update	VERB
gs-3960	475	9	clinicians	clinician	NOUN
gs-3960	475	10	on	on	ADP
gs-3960	475	11	the	the	DET
gs-3960	475	12	latest	late	ADJ
gs-3960	475	13	advances	advance	NOUN
gs-3960	475	14	in	in	ADP
gs-3960	475	15	mitochondrial	mitochondrial	ADJ
gs-3960	475	16	dysfunction	dysfunction	NOUN
gs-3960	475	17	and	and	CCONJ
gs-3960	475	18	emerging	emerge	VERB
gs-3960	475	19	therapeutic	therapeutic	ADJ
gs-3960	475	20	strategies	strategy	NOUN
gs-3960	475	21	in	in	ADP
gs-3960	475	22	parkinson	parkinson	NOUN
gs-3960	475	23	's	's	PART
gs-3960	475	24	disease	disease	NOUN
gs-3960	475	25	.	.	PUNCT
gs-3960	476	1	for	for	ADP
gs-3960	476	2	funding	funding	NOUN
gs-3960	476	3	and	and	CCONJ
gs-3960	476	4	collaboration	collaboration	NOUN
gs-3960	476	5	:	:	PUNCT
gs-3960	476	6	:	:	PUNCT
gs-3960	476	7	funding	funding	NOUN
gs-3960	476	8	agencies	agency	NOUN
gs-3960	476	9	should	should	AUX
gs-3960	476	10	create	create	VERB
gs-3960	476	11	targeted	targeted	ADJ
gs-3960	476	12	programs	program	NOUN
gs-3960	476	13	supporting	support	VERB
gs-3960	476	14	high	high	ADJ
gs-3960	476	15	-	-	PUNCT
gs-3960	476	16	risk	risk	NOUN
gs-3960	476	17	,	,	PUNCT
gs-3960	476	18	high	high	ADJ
gs-3960	476	19	-	-	PUNCT
gs-3960	476	20	reward	reward	NOUN
gs-3960	476	21	research	research	NOUN
gs-3960	476	22	into	into	ADP
gs-3960	476	23	mitochondrial	mitochondrial	ADJ
gs-3960	476	24	mechanisms	mechanism	NOUN
gs-3960	476	25	and	and	CCONJ
gs-3960	476	26	therapies	therapy	NOUN
gs-3960	476	27	for	for	ADP
gs-3960	476	28	parkinson	parkinson	NOUN
gs-3960	476	29	's	's	PART
gs-3960	476	30	disease	disease	NOUN
gs-3960	476	31	,	,	PUNCT
gs-3960	476	32	with	with	ADP
gs-3960	476	33	special	special	ADJ
gs-3960	476	34	emphasis	emphasis	NOUN
gs-3960	476	35	on	on	ADP
gs-3960	476	36	translational	translational	ADJ
gs-3960	476	37	projects	project	NOUN
gs-3960	476	38	.	.	PUNCT
gs-3960	477	1	:	:	PUNCT
gs-3960	477	2	encourage	encourage	VERB
gs-3960	477	3	collaborative	collaborative	ADJ
gs-3960	477	4	consortia	consortium	NOUN
gs-3960	477	5	bringing	bring	VERB
gs-3960	477	6	together	together	ADV
gs-3960	477	7	academic	academic	ADJ
gs-3960	477	8	researchers	researcher	NOUN
gs-3960	477	9	,	,	PUNCT
gs-3960	477	10	biotechnology	biotechnology	NOUN
gs-3960	477	11	companies	company	NOUN
gs-3960	477	12	,	,	PUNCT
gs-3960	477	13	and	and	CCONJ
gs-3960	477	14	pharmaceutical	pharmaceutical	NOUN
gs-3960	477	15	partners	partner	NOUN
gs-3960	477	16	to	to	PART
gs-3960	477	17	accelerate	accelerate	VERB
gs-3960	477	18	therapeutic	therapeutic	ADJ
gs-3960	477	19	development	development	NOUN
gs-3960	477	20	while	while	SCONJ
gs-3960	477	21	maintaining	maintain	VERB
gs-3960	477	22	rigorous	rigorous	ADJ
gs-3960	477	23	scientific	scientific	ADJ
gs-3960	477	24	standards	standard	NOUN
gs-3960	477	25	.	.	PUNCT
gs-3960	478	1	:	:	PUNCT
gs-3960	478	2	develop	develop	VERB
gs-3960	478	3	shared	share	VERB
gs-3960	478	4	databases	database	NOUN
gs-3960	478	5	for	for	ADP
gs-3960	478	6	mitochondrial	mitochondrial	ADJ
gs-3960	478	7	omics	omic	NOUN
gs-3960	478	8	data	datum	NOUN
gs-3960	478	9	,	,	PUNCT
gs-3960	478	10	clinical	clinical	ADJ
gs-3960	478	11	parameters	parameter	NOUN
gs-3960	478	12	,	,	PUNCT
gs-3960	478	13	and	and	CCONJ
gs-3960	478	14	therapeutic	therapeutic	ADJ
gs-3960	478	15	outcomes	outcome	NOUN
gs-3960	478	16	in	in	ADP
gs-3960	478	17	parkinson	parkinson	NOUN
gs-3960	478	18	's	's	PART
gs-3960	478	19	disease	disease	NOUN
gs-3960	478	20	to	to	PART
gs-3960	478	21	facilitate	facilitate	VERB
gs-3960	478	22	data	datum	NOUN
gs-3960	478	23	sharing	sharing	NOUN
gs-3960	478	24	and	and	CCONJ
gs-3960	478	25	collaborative	collaborative	ADJ
gs-3960	478	26	analysis	analysis	NOUN
gs-3960	478	27	across	across	ADP
gs-3960	478	28	institutions	institution	NOUN
gs-3960	478	29	.	.	PUNCT
gs-3960	479	1	georgian	georgian	NOUN
gs-3960	479	2	scientists/	scientists/	NUM
gs-3960	479	3	.	.	PUNCT
gs-3960	480	1	7	7	NUM
gs-3960	480	2	n	n	PRON
gs-3960	480	3	3	3	NUM
gs-3960	480	4	,	,	PUNCT
gs-3960	480	5	2025	2025	NUM
gs-3960	480	6	429	429	NUM
gs-3960	480	7	interdisciplinary	interdisciplinary	ADJ
gs-3960	480	8	collaboration	collaboration	NOUN
gs-3960	480	9	and	and	CCONJ
gs-3960	480	10	infrastructure	infrastructure	NOUN
gs-3960	480	11	the	the	DET
gs-3960	480	12	establishment	establishment	NOUN
gs-3960	480	13	of	of	ADP
gs-3960	480	14	international	international	ADJ
gs-3960	480	15	consortia	consortium	NOUN
gs-3960	480	16	dedicated	dedicate	VERB
gs-3960	480	17	to	to	ADP
gs-3960	480	18	mitochondrial	mitochondrial	ADJ
gs-3960	480	19	research	research	NOUN
gs-3960	480	20	in	in	ADP
gs-3960	480	21	such	such	ADJ
gs-3960	480	22	collaborative	collaborative	ADJ
gs-3960	480	23	efforts	effort	NOUN
gs-3960	480	24	should	should	AUX
gs-3960	480	25	prioritize	prioritize	VERB
gs-3960	480	26	the	the	DET
gs-3960	480	27	creation	creation	NOUN
gs-3960	480	28	of	of	ADP
gs-3960	480	29	open	open	ADJ
gs-3960	480	30	-	-	PUNCT
gs-3960	480	31	access	access	NOUN
gs-3960	480	32	databases	database	NOUN
gs-3960	480	33	containing	contain	VERB
gs-3960	480	34	detailed	detailed	ADJ
gs-3960	480	35	mitochondrial	mitochondrial	ADJ
gs-3960	480	36	phenotypic	phenotypic	NOUN
gs-3960	480	37	data	datum	NOUN
gs-3960	480	38	linked	link	VERB
gs-3960	480	39	to	to	ADP
gs-3960	480	40	comprehensive	comprehensive	ADJ
gs-3960	480	41	clinical	clinical	ADJ
gs-3960	480	42	annotations	annotation	NOUN
gs-3960	480	43	.	.	PUNCT
gs-3960	481	1	academic	academic	ADJ
gs-3960	481	2	institutions	institution	NOUN
gs-3960	481	3	should	should	AUX
gs-3960	481	4	foster	foster	VERB
gs-3960	481	5	structured	structured	ADJ
gs-3960	481	6	training	training	NOUN
gs-3960	481	7	programs	program	NOUN
gs-3960	481	8	at	at	ADP
gs-3960	481	9	the	the	DET
gs-3960	481	10	intersection	intersection	NOUN
gs-3960	481	11	of	of	ADP
gs-3960	481	12	mitochondrial	mitochondrial	ADJ
gs-3960	481	13	biology	biology	NOUN
gs-3960	481	14	and	and	CCONJ
gs-3960	481	15	neuroscience	neuroscience	NOUN
gs-3960	481	16	to	to	PART
gs-3960	481	17	cultivate	cultivate	VERB
gs-3960	481	18	a	a	DET
gs-3960	481	19	new	new	ADJ
gs-3960	481	20	generation	generation	NOUN
gs-3960	481	21	of	of	ADP
gs-3960	481	22	researchers	researcher	NOUN
gs-3960	481	23	equipped	equip	VERB
gs-3960	481	24	to	to	PART
gs-3960	481	25	tackle	tackle	VERB
gs-3960	481	26	the	the	DET
gs-3960	481	27	technical	technical	ADJ
gs-3960	481	28	and	and	CCONJ
gs-3960	481	29	conceptual	conceptual	ADJ
gs-3960	481	30	challenges	challenge	NOUN
gs-3960	481	31	in	in	ADP
gs-3960	481	32	this	this	DET
gs-3960	481	33	field	field	NOUN
gs-3960	481	34	.	.	PUNCT
gs-3960	482	1	joint	joint	ADJ
gs-3960	482	2	appointments	appointment	NOUN
gs-3960	482	3	between	between	ADP
gs-3960	482	4	basic	basic	ADJ
gs-3960	482	5	science	science	NOUN
gs-3960	482	6	departments	department	NOUN
gs-3960	482	7	and	and	CCONJ
gs-3960	482	8	clinical	clinical	ADJ
gs-3960	482	9	neurology	neurology	NOUN
gs-3960	482	10	divisions	division	NOUN
gs-3960	482	11	could	could	AUX
gs-3960	482	12	enhance	enhance	VERB
gs-3960	482	13	translational	translational	ADJ
gs-3960	482	14	research	research	NOUN
gs-3960	482	15	efforts	effort	NOUN
gs-3960	482	16	.	.	PUNCT
gs-3960	483	1	long	long	ADJ
gs-3960	483	2	-	-	PUNCT
gs-3960	483	3	term	term	NOUN
gs-3960	483	4	scientific	scientific	ADJ
gs-3960	483	5	directions	direction	NOUN
gs-3960	483	6	the	the	DET
gs-3960	483	7	investigation	investigation	NOUN
gs-3960	483	8	of	of	ADP
gs-3960	483	9	mitochondrial	mitochondrial	ADJ
gs-3960	483	10	contributions	contribution	NOUN
gs-3960	483	11	to	to	ADP
gs-3960	483	12	non	non	ADJ
gs-3960	483	13	-	-	ADJ
gs-3960	483	14	motor	motor	ADJ
gs-3960	483	15	symptoms	symptom	NOUN
gs-3960	483	16	deserves	deserve	VERB
gs-3960	483	17	greater	great	ADJ
gs-3960	483	18	attention	attention	NOUN
gs-3960	483	19	,	,	PUNCT
gs-3960	483	20	particularly	particularly	ADV
gs-3960	483	21	regarding	regard	VERB
gs-3960	483	22	their	their	PRON
gs-3960	483	23	role	role	NOUN
gs-3960	483	24	in	in	ADP
gs-3960	483	25	gastrointestinal	gastrointestinal	ADJ
gs-3960	483	26	dysfunction	dysfunction	NOUN
gs-3960	483	27	and	and	CCONJ
gs-3960	483	28	sleep	sleep	NOUN
gs-3960	483	29	disturbances	disturbance	NOUN
gs-3960	483	30	that	that	PRON
gs-3960	483	31	often	often	ADV
gs-3960	483	32	precede	precede	VERB
gs-3960	483	33	motor	motor	NOUN
gs-3960	483	34	manifestations	manifestation	NOUN
gs-3960	483	35	.	.	PUNCT
gs-3960	484	1	longitudinal	longitudinal	ADJ
gs-3960	484	2	studies	study	NOUN
gs-3960	484	3	tracking	track	VERB
gs-3960	484	4	mitochondrial	mitochondrial	ADJ
gs-3960	484	5	parameters	parameter	NOUN
gs-3960	484	6	in	in	ADP
gs-3960	484	7	prodromal	prodromal	ADJ
gs-3960	484	8	populations	population	NOUN
gs-3960	484	9	could	could	AUX
gs-3960	484	10	yield	yield	VERB
gs-3960	484	11	critical	critical	ADJ
gs-3960	484	12	insights	insight	NOUN
gs-3960	484	13	into	into	ADP
gs-3960	484	14	early	early	ADJ
gs-3960	484	15	pathogenic	pathogenic	ADJ
gs-3960	484	16	events	event	NOUN
gs-3960	484	17	.	.	PUNCT
gs-3960	485	1	the	the	DET
gs-3960	485	2	potential	potential	NOUN
gs-3960	485	3	for	for	ADP
gs-3960	485	4	circadian	circadian	ADJ
gs-3960	485	5	regulation	regulation	NOUN
gs-3960	485	6	of	of	ADP
gs-3960	485	7	mitochondrial	mitochondrial	ADJ
gs-3960	485	8	function	function	NOUN
gs-3960	485	9	presents	present	VERB
gs-3960	485	10	an	an	DET
gs-3960	485	11	underexplored	underexplored	ADJ
gs-3960	485	12	therapeutic	therapeutic	ADJ
gs-3960	485	13	avenue	avenue	NOUN
gs-3960	485	14	.	.	PUNCT
gs-3960	486	1	chronotherapeutic	chronotherapeutic	ADJ
gs-3960	486	2	approaches	approach	NOUN
gs-3960	486	3	that	that	PRON
gs-3960	486	4	align	align	VERB
gs-3960	486	5	mitochondrial	mitochondrial	ADJ
gs-3960	486	6	biogenesis	biogenesis	NOUN
gs-3960	486	7	and	and	CCONJ
gs-3960	486	8	quality	quality	NOUN
gs-3960	486	9	control	control	NOUN
gs-3960	486	10	with	with	ADP
gs-3960	486	11	natural	natural	ADJ
gs-3960	486	12	biological	biological	ADJ
gs-3960	486	13	rhythms	rhythm	NOUN
gs-3960	486	14	should	should	AUX
gs-3960	486	15	be	be	AUX
gs-3960	486	16	systematically	systematically	ADV
gs-3960	486	17	evaluated	evaluate	VERB
gs-3960	486	18	in	in	ADP
gs-3960	486	19	preclinical	preclinical	ADJ
gs-3960	486	20	models	model	NOUN
gs-3960	486	21	and	and	CCONJ
gs-3960	486	22	human	human	ADJ
gs-3960	486	23	studies	study	NOUN
gs-3960	486	24	.	.	PUNCT
gs-3960	487	1	emerging	emerge	VERB
gs-3960	487	2	technologies	technology	NOUN
gs-3960	487	3	such	such	ADJ
gs-3960	487	4	as	as	ADP
gs-3960	487	5	mitochondrial	mitochondrial	ADJ
gs-3960	487	6	transplantation	transplantation	NOUN
gs-3960	487	7	and	and	CCONJ
gs-3960	487	8	genome	genome	NOUN
gs-3960	487	9	editing	editing	NOUN
gs-3960	487	10	require	require	VERB
gs-3960	487	11	careful	careful	ADJ
gs-3960	487	12	ethical	ethical	ADJ
gs-3960	487	13	and	and	CCONJ
gs-3960	487	14	scientific	scientific	ADJ
gs-3960	487	15	consideration	consideration	NOUN
gs-3960	487	16	.	.	PUNCT
gs-3960	488	1	while	while	SCONJ
gs-3960	488	2	these	these	DET
gs-3960	488	3	approaches	approach	NOUN
gs-3960	488	4	show	show	VERB
gs-3960	488	5	theoretical	theoretical	ADJ
gs-3960	488	6	promise	promise	NOUN
gs-3960	488	7	,	,	PUNCT
gs-3960	488	8	rigorous	rigorous	ADJ
gs-3960	488	9	safety	safety	NOUN
gs-3960	488	10	assessments	assessment	NOUN
gs-3960	488	11	and	and	CCONJ
gs-3960	488	12	mechanistic	mechanistic	ADJ
gs-3960	488	13	studies	study	NOUN
gs-3960	488	14	are	be	AUX
gs-3960	488	15	needed	need	VERB
gs-3960	488	16	before	before	ADP
gs-3960	488	17	clinical	clinical	ADJ
gs-3960	488	18	application	application	NOUN
gs-3960	488	19	.	.	PUNCT
gs-3960	489	1	for	for	ADP
gs-3960	489	2	future	future	ADJ
gs-3960	489	3	directions	direction	NOUN
gs-3960	489	4	:	:	PUNCT
gs-3960	489	5	:	:	PUNCT
gs-3960	489	6	investigate	investigate	VERB
gs-3960	489	7	the	the	DET
gs-3960	489	8	potential	potential	NOUN
gs-3960	489	9	of	of	ADP
gs-3960	489	10	emerging	emerge	VERB
gs-3960	489	11	technologies	technology	NOUN
gs-3960	489	12	for	for	ADP
gs-3960	489	13	mitochondrial	mitochondrial	ADJ
gs-3960	489	14	dna	dna	NOUN
gs-3960	489	15	editing	editing	NOUN
gs-3960	489	16	and	and	CCONJ
gs-3960	489	17	gene	gene	NOUN
gs-3960	489	18	therapy	therapy	NOUN
gs-3960	489	19	approaches	approach	VERB
gs-3960	489	20	targeting	target	VERB
gs-3960	489	21	nuclear	nuclear	NOUN
gs-3960	489	22	-	-	PUNCT
gs-3960	489	23	encoded	encode	VERB
gs-3960	489	24	mitochondrial	mitochondrial	ADJ
gs-3960	489	25	genes	gene	NOUN
gs-3960	489	26	relevant	relevant	ADJ
gs-3960	489	27	to	to	ADP
gs-3960	489	28	parkinson	parkinson	NOUN
gs-3960	489	29	's	's	PART
gs-3960	489	30	pathology	pathology	NOUN
gs-3960	489	31	.	.	PUNCT
gs-3960	490	1	:	:	PUNCT
gs-3960	490	2	expand	expand	VERB
gs-3960	490	3	research	research	NOUN
gs-3960	490	4	beyond	beyond	ADP
gs-3960	490	5	neuronal	neuronal	ADJ
gs-3960	490	6	mitochondria	mitochondria	NOUN
gs-3960	490	7	to	to	PART
gs-3960	490	8	understand	understand	VERB
gs-3960	490	9	how	how	SCONJ
gs-3960	490	10	systemic	systemic	ADJ
gs-3960	490	11	mitochondrial	mitochondrial	ADJ
gs-3960	490	12	dysfunction	dysfunction	NOUN
gs-3960	490	13	in	in	ADP
gs-3960	490	14	other	other	ADJ
gs-3960	490	15	tissues	tissue	NOUN
gs-3960	490	16	(	(	PUNCT
gs-3960	490	17	gut	gut	NOUN
gs-3960	490	18	,	,	PUNCT
gs-3960	490	19	immune	immune	ADJ
gs-3960	490	20	cells	cell	NOUN
gs-3960	490	21	,	,	PUNCT
gs-3960	490	22	muscle	muscle	NOUN
gs-3960	490	23	)	)	PUNCT
gs-3960	490	24	may	may	AUX
gs-3960	490	25	contribute	contribute	VERB
gs-3960	490	26	to	to	ADP
gs-3960	490	27	parkinson	parkinson	NOUN
gs-3960	490	28	's	's	PART
gs-3960	490	29	progression	progression	NOUN
gs-3960	490	30	and	and	CCONJ
gs-3960	490	31	symptoms	symptom	NOUN
gs-3960	490	32	.	.	PUNCT
gs-3960	491	1	:	:	PUNCT
gs-3960	491	2	initiate	initiate	VERB
gs-3960	491	3	long	long	ADJ
gs-3960	491	4	-	-	PUNCT
gs-3960	491	5	term	term	NOUN
gs-3960	491	6	studies	study	NOUN
gs-3960	491	7	to	to	PART
gs-3960	491	8	evaluate	evaluate	VERB
gs-3960	491	9	whether	whether	SCONJ
gs-3960	491	10	early	early	ADJ
gs-3960	491	11	intervention	intervention	NOUN
gs-3960	491	12	in	in	ADP
gs-3960	491	13	mitochondrial	mitochondrial	ADJ
gs-3960	491	14	function	function	NOUN
gs-3960	491	15	in	in	ADP
gs-3960	491	16	at	at	ADP
gs-3960	491	17	-	-	PUNCT
gs-3960	491	18	risk	risk	NOUN
gs-3960	491	19	individuals	individual	NOUN
gs-3960	491	20	can	can	AUX
gs-3960	491	21	delay	delay	VERB
gs-3960	491	22	or	or	CCONJ
gs-3960	491	23	prevent	prevent	VERB
gs-3960	491	24	parkinson	parkinson	NOUN
gs-3960	491	25	's	's	PART
gs-3960	491	26	onset	onset	NOUN
gs-3960	491	27	.	.	PUNCT
gs-3960	492	1	these	these	DET
gs-3960	492	2	suggestions	suggestion	NOUN
gs-3960	492	3	provide	provide	VERB
gs-3960	492	4	a	a	DET
gs-3960	492	5	comprehensive	comprehensive	ADJ
gs-3960	492	6	roadmap	roadmap	NOUN
gs-3960	492	7	for	for	ADP
gs-3960	492	8	advancing	advance	VERB
gs-3960	492	9	both	both	PRON
gs-3960	492	10	scientific	scientific	ADJ
gs-3960	492	11	understanding	understanding	NOUN
gs-3960	492	12	and	and	CCONJ
gs-3960	492	13	clinical	clinical	ADJ
gs-3960	492	14	application	application	NOUN
gs-3960	492	15	of	of	ADP
gs-3960	492	16	mitochondrial	mitochondrial	ADJ
gs-3960	492	17	-	-	PUNCT
gs-3960	492	18	targeted	target	VERB
gs-3960	492	19	approaches	approach	NOUN
gs-3960	492	20	in	in	ADP
gs-3960	492	21	georgian	georgian	PROPN
gs-3960	492	22	scientists/	scientists/	NUM
gs-3960	492	23	.	.	PUNCT
gs-3960	493	1	7	7	NUM
gs-3960	493	2	n	n	PRON
gs-3960	493	3	3	3	NUM
gs-3960	493	4	,	,	PUNCT
gs-3960	493	5	2025	2025	NUM
gs-3960	493	6	430	430	NUM
gs-3960	493	7	parkinson	parkinson	NOUN
gs-3960	493	8	's	's	PART
gs-3960	493	9	disease	disease	NOUN
gs-3960	493	10	.	.	PUNCT
gs-3960	494	1	by	by	ADP
gs-3960	494	2	implementing	implement	VERB
gs-3960	494	3	these	these	DET
gs-3960	494	4	strategies	strategy	NOUN
gs-3960	494	5	,	,	PUNCT
gs-3960	494	6	the	the	DET
gs-3960	494	7	field	field	NOUN
gs-3960	494	8	can	can	AUX
gs-3960	494	9	move	move	VERB
gs-3960	494	10	closer	close	ADV
gs-3960	494	11	to	to	ADP
gs-3960	494	12	developing	develop	VERB
gs-3960	494	13	effective	effective	ADJ
gs-3960	494	14	therapies	therapy	NOUN
gs-3960	494	15	that	that	PRON
gs-3960	494	16	address	address	VERB
gs-3960	494	17	the	the	DET
gs-3960	494	18	root	root	NOUN
gs-3960	494	19	causes	cause	NOUN
gs-3960	494	20	of	of	ADP
gs-3960	494	21	neurodegeneration	neurodegeneration	NOUN
gs-3960	494	22	rather	rather	ADV
gs-3960	494	23	than	than	ADP
gs-3960	494	24	just	just	ADV
gs-3960	494	25	managing	manage	VERB
gs-3960	494	26	symptoms	symptom	NOUN
gs-3960	494	27	.	.	PUNCT
gs-3960	495	1	the	the	DET
gs-3960	495	2	complexity	complexity	NOUN
gs-3960	495	3	of	of	ADP
gs-3960	495	4	mitochondrial	mitochondrial	ADJ
gs-3960	495	5	dysfunction	dysfunction	NOUN
gs-3960	495	6	demands	demand	NOUN
gs-3960	495	7	equally	equally	ADV
gs-3960	495	8	sophisticated	sophisticated	ADJ
gs-3960	495	9	and	and	CCONJ
gs-3960	495	10	coordinated	coordinated	ADJ
gs-3960	495	11	research	research	NOUN
gs-3960	495	12	efforts	effort	NOUN
gs-3960	495	13	,	,	PUNCT
gs-3960	495	14	but	but	CCONJ
gs-3960	495	15	the	the	DET
gs-3960	495	16	potential	potential	ADJ
gs-3960	495	17	payoff	payoff	NOUN
gs-3960	495	18	in	in	ADP
gs-3960	495	19	terms	term	NOUN
gs-3960	495	20	of	of	ADP
gs-3960	495	21	disease	disease	NOUN
gs-3960	495	22	modification	modification	NOUN
gs-3960	495	23	makes	make	VERB
gs-3960	495	24	this	this	PRON
gs-3960	495	25	a	a	DET
gs-3960	495	26	crucial	crucial	ADJ
gs-3960	495	27	investment	investment	NOUN
gs-3960	495	28	for	for	ADP
gs-3960	495	29	the	the	DET
gs-3960	495	30	parkinson	parkinson	NOUN
gs-3960	495	31	's	's	PART
gs-3960	495	32	research	research	NOUN
gs-3960	495	33	community	community	NOUN
gs-3960	495	34	.	.	PUNCT
gs-3960	496	1	conclusions	conclusion	NOUN
gs-3960	496	2	the	the	DET
gs-3960	496	3	comprehensive	comprehensive	ADJ
gs-3960	496	4	exploration	exploration	NOUN
gs-3960	496	5	of	of	ADP
gs-3960	496	6	mitochondrial	mitochondrial	ADJ
gs-3960	496	7	dysfunction	dysfunction	NOUN
gs-3960	496	8	in	in	ADP
gs-3960	496	9	parkinson	parkinson	NOUN
gs-3960	496	10	's	's	PART
gs-3960	496	11	disease	disease	NOUN
gs-3960	496	12	reveals	reveal	VERB
gs-3960	496	13	an	an	DET
gs-3960	496	14	increasingly	increasingly	ADV
gs-3960	496	15	complex	complex	ADJ
gs-3960	496	16	and	and	CCONJ
gs-3960	496	17	multifaceted	multifaceted	ADJ
gs-3960	496	18	picture	picture	NOUN
gs-3960	496	19	that	that	PRON
gs-3960	496	20	fundamentally	fundamentally	ADV
gs-3960	496	21	alters	alter	VERB
gs-3960	496	22	our	our	PRON
gs-3960	496	23	understanding	understanding	NOUN
gs-3960	496	24	of	of	ADP
gs-3960	496	25	neurodegenerative	neurodegenerative	ADJ
gs-3960	496	26	processes	process	NOUN
gs-3960	496	27	.	.	PUNCT
gs-3960	497	1	the	the	DET
gs-3960	497	2	emerging	emerge	VERB
gs-3960	497	3	paradigm	paradigm	NOUN
gs-3960	497	4	positions	position	NOUN
gs-3960	497	5	mitochondria	mitochondria	VERB
gs-3960	497	6	not	not	PART
gs-3960	497	7	merely	merely	ADV
gs-3960	497	8	as	as	ADP
gs-3960	497	9	passive	passive	ADJ
gs-3960	497	10	energy	energy	NOUN
gs-3960	497	11	producers	producer	NOUN
gs-3960	497	12	but	but	CCONJ
gs-3960	497	13	as	as	ADP
gs-3960	497	14	dynamic	dynamic	ADJ
gs-3960	497	15	signaling	signal	VERB
gs-3960	497	16	hubs	hub	NOUN
gs-3960	497	17	that	that	PRON
gs-3960	497	18	integrate	integrate	VERB
gs-3960	497	19	metabolic	metabolic	NOUN
gs-3960	497	20	,	,	PUNCT
gs-3960	497	21	proteostatic	proteostatic	NOUN
gs-3960	497	22	,	,	PUNCT
gs-3960	497	23	and	and	CCONJ
gs-3960	497	24	inflammatory	inflammatory	ADJ
gs-3960	497	25	information	information	NOUN
gs-3960	497	26	to	to	PART
gs-3960	497	27	determine	determine	VERB
gs-3960	497	28	neuronal	neuronal	ADJ
gs-3960	497	29	fate	fate	NOUN
gs-3960	497	30	.	.	PUNCT
gs-3960	498	1	this	this	DET
gs-3960	498	2	expanded	expand	VERB
gs-3960	498	3	view	view	NOUN
gs-3960	498	4	explains	explain	VERB
gs-3960	498	5	both	both	CCONJ
gs-3960	498	6	the	the	DET
gs-3960	498	7	selective	selective	ADJ
gs-3960	498	8	vulnerability	vulnerability	NOUN
gs-3960	498	9	of	of	ADP
gs-3960	498	10	dopaminergic	dopaminergic	ADJ
gs-3960	498	11	neurons	neuron	NOUN
gs-3960	498	12	and	and	CCONJ
gs-3960	498	13	the	the	DET
gs-3960	498	14	systemic	systemic	ADJ
gs-3960	498	15	nature	nature	NOUN
gs-3960	498	16	of	of	ADP
gs-3960	498	17	parkinson	parkinson	NOUN
gs-3960	498	18	's	's	PART
gs-3960	498	19	pathology	pathology	NOUN
gs-3960	498	20	,	,	PUNCT
gs-3960	498	21	bridging	bridge	VERB
gs-3960	498	22	the	the	DET
gs-3960	498	23	gap	gap	NOUN
gs-3960	498	24	between	between	ADP
gs-3960	498	25	genetic	genetic	ADJ
gs-3960	498	26	predisposition	predisposition	NOUN
gs-3960	498	27	and	and	CCONJ
gs-3960	498	28	environmental	environmental	ADJ
gs-3960	498	29	risk	risk	NOUN
gs-3960	498	30	factors	factor	NOUN
gs-3960	498	31	.	.	PUNCT
gs-3960	499	1	the	the	DET
gs-3960	499	2	depth	depth	NOUN
gs-3960	499	3	of	of	ADP
gs-3960	499	4	mitochondrial	mitochondrial	ADJ
gs-3960	499	5	involvement	involvement	NOUN
gs-3960	499	6	in	in	ADP
gs-3960	499	7	parkinson	parkinson	NOUN
gs-3960	499	8	's	's	PART
gs-3960	499	9	pathogenesis	pathogenesis	NOUN
gs-3960	499	10	extends	extend	VERB
gs-3960	499	11	far	far	ADV
gs-3960	499	12	beyond	beyond	ADP
gs-3960	499	13	classical	classical	ADJ
gs-3960	499	14	bioenergetic	bioenergetic	ADJ
gs-3960	499	15	failure	failure	NOUN
gs-3960	499	16	to	to	PART
gs-3960	499	17	encompass	encompass	VERB
gs-3960	499	18	nearly	nearly	ADV
gs-3960	499	19	all	all	PRON
gs-3960	499	20	aspects	aspect	NOUN
gs-3960	499	21	of	of	ADP
gs-3960	499	22	cellular	cellular	ADJ
gs-3960	499	23	homeostasis	homeostasis	NOUN
gs-3960	499	24	.	.	PUNCT
gs-3960	500	1	from	from	ADP
gs-3960	500	2	the	the	DET
gs-3960	500	3	sophisticated	sophisticated	ADJ
gs-3960	500	4	regulation	regulation	NOUN
gs-3960	500	5	of	of	ADP
gs-3960	500	6	protein	protein	NOUN
gs-3960	500	7	import	import	NOUN
gs-3960	500	8	machinery	machinery	NOUN
gs-3960	500	9	to	to	ADP
gs-3960	500	10	the	the	DET
gs-3960	500	11	nuanced	nuanced	ADJ
gs-3960	500	12	signaling	signal	VERB
gs-3960	500	13	through	through	ADP
gs-3960	500	14	mitochondrial	mitochondrial	ADJ
gs-3960	500	15	-	-	PUNCT
gs-3960	500	16	derived	derive	VERB
gs-3960	500	17	vesicles	vesicle	NOUN
gs-3960	500	18	and	and	CCONJ
gs-3960	500	19	peptides	peptide	NOUN
gs-3960	500	20	,	,	PUNCT
gs-3960	500	21	these	these	DET
gs-3960	500	22	organelles	organelle	NOUN
gs-3960	500	23	participate	participate	VERB
gs-3960	500	24	in	in	ADP
gs-3960	500	25	cellular	cellular	ADJ
gs-3960	500	26	decision	decision	NOUN
gs-3960	500	27	-	-	PUNCT
gs-3960	500	28	making	make	VERB
gs-3960	500	29	processes	process	NOUN
gs-3960	500	30	that	that	PRON
gs-3960	500	31	ultimately	ultimately	ADV
gs-3960	500	32	determine	determine	VERB
gs-3960	500	33	neuronal	neuronal	ADJ
gs-3960	500	34	survival	survival	NOUN
gs-3960	500	35	.	.	PUNCT
gs-3960	501	1	the	the	DET
gs-3960	501	2	discovery	discovery	NOUN
gs-3960	501	3	of	of	ADP
gs-3960	501	4	mitochondrial	mitochondrial	ADJ
gs-3960	501	5	epitranscriptomics	epitranscriptomic	NOUN
gs-3960	501	6	and	and	CCONJ
gs-3960	501	7	interorganelle	interorganelle	NOUN
gs-3960	501	8	communication	communication	NOUN
gs-3960	501	9	networks	network	NOUN
gs-3960	501	10	adds	add	VERB
gs-3960	501	11	additional	additional	ADJ
gs-3960	501	12	layers	layer	NOUN
gs-3960	501	13	of	of	ADP
gs-3960	501	14	complexity	complexity	NOUN
gs-3960	501	15	to	to	ADP
gs-3960	501	16	our	our	PRON
gs-3960	501	17	understanding	understanding	NOUN
gs-3960	501	18	of	of	ADP
gs-3960	501	19	how	how	SCONJ
gs-3960	501	20	mitochondrial	mitochondrial	ADJ
gs-3960	501	21	dysfunction	dysfunction	NOUN
gs-3960	501	22	propagates	propagate	VERB
gs-3960	501	23	through	through	ADP
gs-3960	501	24	neuronal	neuronal	ADJ
gs-3960	501	25	circuits	circuit	NOUN
gs-3960	501	26	.	.	PUNCT
gs-3960	502	1	recent	recent	ADJ
gs-3960	502	2	advances	advance	NOUN
gs-3960	502	3	have	have	AUX
gs-3960	502	4	particularly	particularly	ADV
gs-3960	502	5	illuminated	illuminate	VERB
gs-3960	502	6	the	the	DET
gs-3960	502	7	temporal	temporal	ADJ
gs-3960	502	8	dimension	dimension	NOUN
gs-3960	502	9	of	of	ADP
gs-3960	502	10	mitochondrial	mitochondrial	ADJ
gs-3960	502	11	dysfunction	dysfunction	NOUN
gs-3960	502	12	in	in	ADP
gs-3960	502	13	parkinson	parkinson	NOUN
gs-3960	502	14	's	's	PART
gs-3960	502	15	disease	disease	NOUN
gs-3960	502	16	.	.	PUNCT
gs-3960	503	1	the	the	DET
gs-3960	503	2	recognition	recognition	NOUN
gs-3960	503	3	of	of	ADP
gs-3960	503	4	mitochondrial	mitochondrial	ADJ
gs-3960	503	5	aging	age	VERB
gs-3960	503	6	clocks	clock	NOUN
gs-3960	503	7	and	and	CCONJ
gs-3960	503	8	circadian	circadian	ADJ
gs-3960	503	9	regulation	regulation	NOUN
gs-3960	503	10	of	of	ADP
gs-3960	503	11	quality	quality	NOUN
gs-3960	503	12	control	control	NOUN
gs-3960	503	13	mechanisms	mechanism	NOUN
gs-3960	503	14	provides	provide	VERB
gs-3960	503	15	crucial	crucial	ADJ
gs-3960	503	16	insights	insight	NOUN
gs-3960	503	17	into	into	ADP
gs-3960	503	18	why	why	SCONJ
gs-3960	503	19	parkinson	parkinson	NOUN
gs-3960	503	20	's	's	PART
gs-3960	503	21	typically	typically	ADV
gs-3960	503	22	manifests	manifest	NOUN
gs-3960	503	23	later	later	ADV
gs-3960	503	24	in	in	ADP
gs-3960	503	25	life	life	NOUN
gs-3960	503	26	and	and	CCONJ
gs-3960	503	27	progresses	progress	NOUN
gs-3960	503	28	gradually	gradually	ADV
gs-3960	503	29	.	.	PUNCT
gs-3960	504	1	these	these	DET
gs-3960	504	2	temporal	temporal	ADJ
gs-3960	504	3	aspects	aspect	NOUN
gs-3960	504	4	interact	interact	VERB
gs-3960	504	5	with	with	ADP
gs-3960	504	6	genetic	genetic	ADJ
gs-3960	504	7	and	and	CCONJ
gs-3960	504	8	environmental	environmental	ADJ
gs-3960	504	9	factors	factor	NOUN
gs-3960	504	10	to	to	PART
gs-3960	504	11	create	create	VERB
gs-3960	504	12	unique	unique	ADJ
gs-3960	504	13	patterns	pattern	NOUN
gs-3960	504	14	of	of	ADP
gs-3960	504	15	vulnerability	vulnerability	NOUN
gs-3960	504	16	that	that	PRON
gs-3960	504	17	may	may	AUX
gs-3960	504	18	explain	explain	VERB
gs-3960	504	19	the	the	DET
gs-3960	504	20	considerable	considerable	ADJ
gs-3960	504	21	heterogeneity	heterogeneity	NOUN
gs-3960	504	22	observed	observe	VERB
gs-3960	504	23	in	in	ADP
gs-3960	504	24	patient	patient	ADJ
gs-3960	504	25	populations	population	NOUN
gs-3960	504	26	.	.	PUNCT
gs-3960	505	1	the	the	DET
gs-3960	505	2	therapeutic	therapeutic	ADJ
gs-3960	505	3	implications	implication	NOUN
gs-3960	505	4	of	of	ADP
gs-3960	505	5	these	these	DET
gs-3960	505	6	discoveries	discovery	NOUN
gs-3960	505	7	are	be	AUX
gs-3960	505	8	profound	profound	ADJ
gs-3960	505	9	and	and	CCONJ
gs-3960	505	10	far	far	ADV
gs-3960	505	11	-	-	PUNCT
gs-3960	505	12	reaching	reach	VERB
gs-3960	505	13	.	.	PUNCT
gs-3960	506	1	while	while	SCONJ
gs-3960	506	2	traditional	traditional	ADJ
gs-3960	506	3	approaches	approach	NOUN
gs-3960	506	4	focused	focus	VERB
gs-3960	506	5	narrowly	narrowly	ADV
gs-3960	506	6	on	on	ADP
gs-3960	506	7	boosting	boost	VERB
gs-3960	506	8	atp	atp	NOUN
gs-3960	506	9	production	production	NOUN
gs-3960	506	10	or	or	CCONJ
gs-3960	506	11	scavenging	scavenge	VERB
gs-3960	506	12	reactive	reactive	ADJ
gs-3960	506	13	oxygen	oxygen	NOUN
gs-3960	506	14	species	specie	NOUN
gs-3960	506	15	,	,	PUNCT
gs-3960	506	16	the	the	DET
gs-3960	506	17	new	new	ADJ
gs-3960	506	18	understanding	understanding	NOUN
gs-3960	506	19	demands	demand	VERB
gs-3960	506	20	more	more	ADV
gs-3960	506	21	sophisticated	sophisticated	ADJ
gs-3960	506	22	interventions	intervention	NOUN
gs-3960	506	23	that	that	PRON
gs-3960	506	24	restore	restore	VERB
gs-3960	506	25	the	the	DET
gs-3960	506	26	integrative	integrative	ADJ
gs-3960	506	27	functions	function	NOUN
gs-3960	506	28	of	of	ADP
gs-3960	506	29	mitochondrial	mitochondrial	ADJ
gs-3960	506	30	networks	network	NOUN
gs-3960	506	31	.	.	PUNCT
gs-3960	507	1	the	the	DET
gs-3960	507	2	most	most	ADV
gs-3960	507	3	promising	promising	ADJ
gs-3960	507	4	strategies	strategy	NOUN
gs-3960	507	5	emerging	emerge	VERB
gs-3960	507	6	from	from	ADP
gs-3960	507	7	current	current	ADJ
gs-3960	507	8	research	research	NOUN
gs-3960	507	9	aim	aim	NOUN
gs-3960	507	10	to	to	PART
gs-3960	507	11	enhance	enhance	VERB
gs-3960	507	12	mitochondrial	mitochondrial	ADJ
gs-3960	507	13	plasticity	plasticity	NOUN
gs-3960	507	14	,	,	PUNCT
gs-3960	507	15	improve	improve	VERB
gs-3960	507	16	interorganelle	interorganelle	ADJ
gs-3960	507	17	communication	communication	NOUN
gs-3960	507	18	,	,	PUNCT
gs-3960	507	19	and	and	CCONJ
gs-3960	507	20	restore	restore	VERB
gs-3960	507	21	proper	proper	ADJ
gs-3960	507	22	protein	protein	NOUN
gs-3960	507	23	homeostasis	homeostasis	NOUN
gs-3960	507	24	rather	rather	ADV
gs-3960	507	25	than	than	ADP
gs-3960	507	26	simply	simply	ADV
gs-3960	507	27	augment	augment	VERB
gs-3960	507	28	energy	energy	NOUN
gs-3960	507	29	metabolism	metabolism	NOUN
gs-3960	507	30	.	.	PUNCT
gs-3960	508	1	personalized	personalize	VERB
gs-3960	508	2	medicine	medicine	NOUN
gs-3960	508	3	approaches	approach	NOUN
gs-3960	508	4	will	will	AUX
gs-3960	508	5	be	be	AUX
gs-3960	508	6	essential	essential	ADJ
gs-3960	508	7	for	for	ADP
gs-3960	508	8	translating	translate	VERB
gs-3960	508	9	these	these	DET
gs-3960	508	10	insights	insight	NOUN
gs-3960	508	11	into	into	ADP
gs-3960	508	12	clinical	clinical	ADJ
gs-3960	508	13	practice	practice	NOUN
gs-3960	508	14	.	.	PUNCT
gs-3960	509	1	the	the	DET
gs-3960	509	2	recognition	recognition	NOUN
gs-3960	509	3	of	of	ADP
gs-3960	509	4	distinct	distinct	ADJ
gs-3960	509	5	mitochondrial	mitochondrial	ADJ
gs-3960	509	6	dysfunction	dysfunction	NOUN
gs-3960	509	7	subtypes	subtype	NOUN
gs-3960	509	8	in	in	ADP
gs-3960	509	9	georgian	georgian	PROPN
gs-3960	509	10	scientists/	scientists/	NUM
gs-3960	509	11	.	.	PUNCT
gs-3960	510	1	7	7	NUM
gs-3960	510	2	n	n	PRON
gs-3960	510	3	3	3	NUM
gs-3960	510	4	,	,	PUNCT
gs-3960	510	5	2025	2025	NUM
gs-3960	510	6	431	431	NUM
gs-3960	510	7	parkinson	parkinson	NOUN
gs-3960	510	8	's	's	PART
gs-3960	510	9	patients	patient	NOUN
gs-3960	510	10	suggests	suggest	VERB
gs-3960	510	11	that	that	SCONJ
gs-3960	510	12	future	future	ADJ
gs-3960	510	13	treatments	treatment	NOUN
gs-3960	510	14	may	may	AUX
gs-3960	510	15	need	need	VERB
gs-3960	510	16	to	to	PART
gs-3960	510	17	be	be	AUX
gs-3960	510	18	tailored	tailor	VERB
gs-3960	510	19	based	base	VERB
gs-3960	510	20	on	on	ADP
gs-3960	510	21	individual	individual	ADJ
gs-3960	510	22	patterns	pattern	NOUN
gs-3960	510	23	of	of	ADP
gs-3960	510	24	import	import	NOUN
gs-3960	510	25	defects	defect	NOUN
gs-3960	510	26	,	,	PUNCT
gs-3960	510	27	respiratory	respiratory	ADJ
gs-3960	510	28	chain	chain	NOUN
gs-3960	510	29	deficiencies	deficiency	NOUN
gs-3960	510	30	,	,	PUNCT
gs-3960	510	31	or	or	CCONJ
gs-3960	510	32	quality	quality	NOUN
gs-3960	510	33	control	control	NOUN
gs-3960	510	34	impairments	impairment	NOUN
gs-3960	510	35	.	.	PUNCT
gs-3960	511	1	advanced	advanced	ADJ
gs-3960	511	2	diagnostic	diagnostic	ADJ
gs-3960	511	3	tools	tool	NOUN
gs-3960	511	4	,	,	PUNCT
gs-3960	511	5	particularly	particularly	ADV
gs-3960	511	6	those	those	PRON
gs-3960	511	7	combining	combine	VERB
gs-3960	511	8	functional	functional	ADJ
gs-3960	511	9	imaging	imaging	NOUN
gs-3960	511	10	with	with	ADP
gs-3960	511	11	multi	multi	ADJ
gs-3960	511	12	-	-	ADJ
gs-3960	511	13	omics	omics	ADJ
gs-3960	511	14	profiling	profiling	NOUN
gs-3960	511	15	,	,	PUNCT
gs-3960	511	16	will	will	AUX
gs-3960	511	17	be	be	AUX
gs-3960	511	18	crucial	crucial	ADJ
gs-3960	511	19	for	for	ADP
gs-3960	511	20	identifying	identify	VERB
gs-3960	511	21	the	the	DET
gs-3960	511	22	most	most	ADV
gs-3960	511	23	appropriate	appropriate	ADJ
gs-3960	511	24	mitochondrial	mitochondrial	ADJ
gs-3960	511	25	-	-	PUNCT
gs-3960	511	26	targeted	target	VERB
gs-3960	511	27	therapies	therapy	NOUN
gs-3960	511	28	for	for	ADP
gs-3960	511	29	each	each	DET
gs-3960	511	30	patient	patient	NOUN
gs-3960	511	31	.	.	PUNCT
gs-3960	512	1	the	the	DET
gs-3960	512	2	broader	broad	ADJ
gs-3960	512	3	implications	implication	NOUN
gs-3960	512	4	of	of	ADP
gs-3960	512	5	this	this	DET
gs-3960	512	6	research	research	NOUN
gs-3960	512	7	extend	extend	VERB
gs-3960	512	8	well	well	ADV
gs-3960	512	9	beyond	beyond	ADP
gs-3960	512	10	parkinson	parkinson	NOUN
gs-3960	512	11	's	's	PART
gs-3960	512	12	disease	disease	NOUN
gs-3960	512	13	.	.	PUNCT
gs-3960	513	1	the	the	DET
gs-3960	513	2	principles	principle	NOUN
gs-3960	513	3	emerging	emerge	VERB
gs-3960	513	4	from	from	ADP
gs-3960	513	5	these	these	DET
gs-3960	513	6	studies	study	NOUN
gs-3960	513	7	particularly	particularly	ADV
gs-3960	513	8	regarding	regard	VERB
gs-3960	513	9	mitochondrial	mitochondrial	ADJ
gs-3960	513	10	communication	communication	NOUN
gs-3960	513	11	networks	network	NOUN
gs-3960	513	12	,	,	PUNCT
gs-3960	513	13	stress	stress	NOUN
gs-3960	513	14	response	response	NOUN
gs-3960	513	15	integration	integration	NOUN
gs-3960	513	16	,	,	PUNCT
gs-3960	513	17	and	and	CCONJ
gs-3960	513	18	aging	age	VERB
gs-3960	513	19	regulation	regulation	NOUN
gs-3960	513	20	likely	likely	ADV
gs-3960	513	21	apply	apply	VERB
gs-3960	513	22	to	to	ADP
gs-3960	513	23	numerous	numerous	ADJ
gs-3960	513	24	other	other	ADJ
gs-3960	513	25	neurodegenerative	neurodegenerative	ADJ
gs-3960	513	26	conditions	condition	NOUN
gs-3960	513	27	and	and	CCONJ
gs-3960	513	28	even	even	ADV
gs-3960	513	29	the	the	DET
gs-3960	513	30	normal	normal	ADJ
gs-3960	513	31	aging	age	VERB
gs-3960	513	32	process	process	NOUN
gs-3960	513	33	.	.	PUNCT
gs-3960	514	1	this	this	DET
gs-3960	514	2	positions	position	NOUN
gs-3960	514	3	mitochondrial	mitochondrial	ADJ
gs-3960	514	4	medicine	medicine	NOUN
gs-3960	514	5	as	as	ADP
gs-3960	514	6	a	a	DET
gs-3960	514	7	potentially	potentially	ADV
gs-3960	514	8	transformative	transformative	ADJ
gs-3960	514	9	approach	approach	NOUN
gs-3960	514	10	for	for	ADP
gs-3960	514	11	maintaining	maintain	VERB
gs-3960	514	12	neurological	neurological	ADJ
gs-3960	514	13	health	health	NOUN
gs-3960	514	14	across	across	ADP
gs-3960	514	15	the	the	DET
gs-3960	514	16	lifespan	lifespan	NOUN
gs-3960	514	17	.	.	PUNCT
gs-3960	515	1	while	while	SCONJ
gs-3960	515	2	significant	significant	ADJ
gs-3960	515	3	challenges	challenge	NOUN
gs-3960	515	4	remain	remain	VERB
gs-3960	515	5	in	in	ADP
gs-3960	515	6	drug	drug	NOUN
gs-3960	515	7	delivery	delivery	NOUN
gs-3960	515	8	,	,	PUNCT
gs-3960	515	9	target	target	NOUN
gs-3960	515	10	specificity	specificity	NOUN
gs-3960	515	11	,	,	PUNCT
gs-3960	515	12	and	and	CCONJ
gs-3960	515	13	clinical	clinical	ADJ
gs-3960	515	14	trial	trial	NOUN
gs-3960	515	15	design	design	NOUN
gs-3960	515	16	,	,	PUNCT
gs-3960	515	17	the	the	DET
gs-3960	515	18	pace	pace	NOUN
gs-3960	515	19	of	of	ADP
gs-3960	515	20	discovery	discovery	NOUN
gs-3960	515	21	in	in	ADP
gs-3960	515	22	mitochondrial	mitochondrial	ADJ
gs-3960	515	23	biology	biology	NOUN
gs-3960	515	24	offers	offer	VERB
gs-3960	515	25	genuine	genuine	ADJ
gs-3960	515	26	hope	hope	NOUN
gs-3960	515	27	for	for	ADP
gs-3960	515	28	disease	disease	NOUN
gs-3960	515	29	-	-	PUNCT
gs-3960	515	30	modifying	modify	VERB
gs-3960	515	31	therapies	therapy	NOUN
gs-3960	515	32	.	.	PUNCT
gs-3960	516	1	the	the	DET
gs-3960	516	2	convergence	convergence	NOUN
gs-3960	516	3	of	of	ADP
gs-3960	516	4	advanced	advanced	ADJ
gs-3960	516	5	imaging	imaging	NOUN
gs-3960	516	6	techniques	technique	NOUN
gs-3960	516	7	,	,	PUNCT
gs-3960	516	8	stem	stem	NOUN
gs-3960	516	9	cell	cell	NOUN
gs-3960	516	10	technology	technology	NOUN
gs-3960	516	11	,	,	PUNCT
gs-3960	516	12	and	and	CCONJ
gs-3960	516	13	innovative	innovative	ADJ
gs-3960	516	14	therapeutic	therapeutic	ADJ
gs-3960	516	15	modalities	modality	NOUN
gs-3960	516	16	creates	create	VERB
gs-3960	516	17	unprecedented	unprecedented	ADJ
gs-3960	516	18	opportunities	opportunity	NOUN
gs-3960	516	19	to	to	PART
gs-3960	516	20	intervene	intervene	VERB
gs-3960	516	21	in	in	ADP
gs-3960	516	22	the	the	DET
gs-3960	516	23	disease	disease	NOUN
gs-3960	516	24	process	process	NOUN
gs-3960	516	25	.	.	PUNCT
gs-3960	517	1	as	as	SCONJ
gs-3960	517	2	these	these	DET
gs-3960	517	3	approaches	approach	NOUN
gs-3960	517	4	mature	mature	VERB
gs-3960	517	5	,	,	PUNCT
gs-3960	517	6	we	we	PRON
gs-3960	517	7	may	may	AUX
gs-3960	517	8	soon	soon	ADV
gs-3960	517	9	see	see	VERB
gs-3960	517	10	treatments	treatment	NOUN
gs-3960	517	11	that	that	PRON
gs-3960	517	12	not	not	PART
gs-3960	517	13	only	only	ADV
gs-3960	517	14	slow	slow	VERB
gs-3960	517	15	parkinson	parkinson	NOUN
gs-3960	517	16	's	's	PART
gs-3960	517	17	progression	progression	NOUN
gs-3960	517	18	but	but	CCONJ
gs-3960	517	19	potentially	potentially	ADV
gs-3960	517	20	restore	restore	VERB
gs-3960	517	21	function	function	NOUN
gs-3960	517	22	by	by	ADP
gs-3960	517	23	enhancing	enhance	VERB
gs-3960	517	24	mitochondrial	mitochondrial	ADJ
gs-3960	517	25	network	network	NOUN
gs-3960	517	26	resilience	resilience	NOUN
gs-3960	517	27	.	.	PUNCT
gs-3960	518	1	ultimately	ultimately	ADV
gs-3960	518	2	,	,	PUNCT
gs-3960	518	3	the	the	DET
gs-3960	518	4	study	study	NOUN
gs-3960	518	5	of	of	ADP
gs-3960	518	6	mitochondrial	mitochondrial	ADJ
gs-3960	518	7	dysfunction	dysfunction	NOUN
gs-3960	518	8	in	in	ADP
gs-3960	518	9	parkinson	parkinson	NOUN
gs-3960	518	10	's	's	PART
gs-3960	518	11	disease	disease	NOUN
gs-3960	518	12	has	have	AUX
gs-3960	518	13	evolved	evolve	VERB
gs-3960	518	14	from	from	ADP
gs-3960	518	15	a	a	DET
gs-3960	518	16	narrow	narrow	ADJ
gs-3960	518	17	focus	focus	NOUN
gs-3960	518	18	on	on	ADP
gs-3960	518	19	energy	energy	NOUN
gs-3960	518	20	metabolism	metabolism	NOUN
gs-3960	518	21	to	to	ADP
gs-3960	518	22	a	a	DET
gs-3960	518	23	comprehensive	comprehensive	ADJ
gs-3960	518	24	appreciation	appreciation	NOUN
gs-3960	518	25	of	of	ADP
gs-3960	518	26	these	these	DET
gs-3960	518	27	organelles	organelle	NOUN
gs-3960	518	28	as	as	ADP
gs-3960	518	29	central	central	ADJ
gs-3960	518	30	regulators	regulator	NOUN
gs-3960	518	31	of	of	ADP
gs-3960	518	32	neuronal	neuronal	ADJ
gs-3960	518	33	health	health	NOUN
gs-3960	518	34	.	.	PUNCT
gs-3960	519	1	this	this	DET
gs-3960	519	2	paradigm	paradigm	NOUN
gs-3960	519	3	shift	shift	NOUN
gs-3960	519	4	continues	continue	VERB
gs-3960	519	5	to	to	PART
gs-3960	519	6	yield	yield	VERB
gs-3960	519	7	surprising	surprising	ADJ
gs-3960	519	8	insights	insight	NOUN
gs-3960	519	9	while	while	SCONJ
gs-3960	519	10	opening	open	VERB
gs-3960	519	11	new	new	ADJ
gs-3960	519	12	therapeutic	therapeutic	ADJ
gs-3960	519	13	avenues	avenue	NOUN
gs-3960	519	14	.	.	PUNCT
gs-3960	520	1	as	as	SCONJ
gs-3960	520	2	research	research	NOUN
gs-3960	520	3	progresses	progress	NOUN
gs-3960	520	4	,	,	PUNCT
gs-3960	520	5	the	the	DET
gs-3960	520	6	integration	integration	NOUN
gs-3960	520	7	of	of	ADP
gs-3960	520	8	mitochondrial	mitochondrial	ADJ
gs-3960	520	9	medicine	medicine	NOUN
gs-3960	520	10	into	into	ADP
gs-3960	520	11	clinical	clinical	ADJ
gs-3960	520	12	practice	practice	NOUN
gs-3960	520	13	promises	promise	NOUN
gs-3960	520	14	to	to	PART
gs-3960	520	15	revolutionize	revolutionize	VERB
gs-3960	520	16	our	our	PRON
gs-3960	520	17	approach	approach	NOUN
gs-3960	520	18	to	to	ADP
gs-3960	520	19	parkinson	parkinson	NOUN
gs-3960	520	20	's	's	PART
gs-3960	520	21	disease	disease	NOUN
gs-3960	520	22	and	and	CCONJ
gs-3960	520	23	related	relate	VERB
gs-3960	520	24	neurodegenerative	neurodegenerative	ADJ
gs-3960	520	25	disorders	disorder	NOUN
gs-3960	520	26	,	,	PUNCT
gs-3960	520	27	offering	offer	VERB
gs-3960	520	28	the	the	DET
gs-3960	520	29	potential	potential	NOUN
gs-3960	520	30	for	for	ADP
gs-3960	520	31	meaningful	meaningful	ADJ
gs-3960	520	32	improvements	improvement	NOUN
gs-3960	520	33	in	in	ADP
gs-3960	520	34	patient	patient	ADJ
gs-3960	520	35	outcomes	outcome	NOUN
gs-3960	520	36	and	and	CCONJ
gs-3960	520	37	quality	quality	NOUN
gs-3960	520	38	of	of	ADP
gs-3960	520	39	life	life	NOUN
gs-3960	520	40	.	.	PUNCT
gs-3960	521	1	the	the	DET
gs-3960	521	2	journey	journey	NOUN
gs-3960	521	3	from	from	ADP
gs-3960	521	4	bench	bench	NOUN
gs-3960	521	5	to	to	ADP
gs-3960	521	6	bedside	bedside	NOUN
gs-3960	521	7	remains	remain	VERB
gs-3960	521	8	challenging	challenging	ADJ
gs-3960	521	9	,	,	PUNCT
gs-3960	521	10	but	but	CCONJ
gs-3960	521	11	the	the	DET
gs-3960	521	12	remarkable	remarkable	ADJ
gs-3960	521	13	progress	progress	NOUN
gs-3960	521	14	in	in	ADP
gs-3960	521	15	understanding	understand	VERB
gs-3960	521	16	mitochondrial	mitochondrial	ADJ
gs-3960	521	17	pathobiology	pathobiology	NOUN
gs-3960	521	18	provides	provide	VERB
gs-3960	521	19	compelling	compelling	ADJ
gs-3960	521	20	reasons	reason	NOUN
gs-3960	521	21	for	for	ADP
gs-3960	521	22	optimism	optimism	NOUN
gs-3960	521	23	in	in	ADP
gs-3960	521	24	the	the	DET
gs-3960	521	25	fight	fight	NOUN
gs-3960	521	26	against	against	ADP
gs-3960	521	27	parkinson	parkinson	NOUN
gs-3960	521	28	's	's	PART
gs-3960	521	29	disease	disease	NOUN
gs-3960	521	30	.	.	PUNCT
gs-3960	522	1	recommendations	recommendation	NOUN
gs-3960	522	2	the	the	DET
gs-3960	522	3	growing	grow	VERB
gs-3960	522	4	body	body	NOUN
gs-3960	522	5	of	of	ADP
gs-3960	522	6	evidence	evidence	NOUN
gs-3960	522	7	implicating	implicate	VERB
gs-3960	522	8	mitochondrial	mitochondrial	ADJ
gs-3960	522	9	dysfunction	dysfunction	NOUN
gs-3960	522	10	as	as	ADP
gs-3960	522	11	a	a	DET
gs-3960	522	12	central	central	ADJ
gs-3960	522	13	approach	approach	NOUN
gs-3960	522	14	to	to	ADP
gs-3960	522	15	future	future	ADJ
gs-3960	522	16	research	research	NOUN
gs-3960	522	17	and	and	CCONJ
gs-3960	522	18	therapeutic	therapeutic	ADJ
gs-3960	522	19	development	development	NOUN
gs-3960	522	20	.	.	PUNCT
gs-3960	523	1	to	to	PART
gs-3960	523	2	address	address	VERB
gs-3960	523	3	the	the	DET
gs-3960	523	4	complexities	complexity	NOUN
gs-3960	523	5	of	of	ADP
gs-3960	523	6	mitochondrial	mitochondrial	ADJ
gs-3960	523	7	biology	biology	NOUN
gs-3960	523	8	and	and	CCONJ
gs-3960	523	9	its	its	PRON
gs-3960	523	10	intersection	intersection	NOUN
gs-3960	523	11	with	with	ADP
gs-3960	523	12	neurodegenerative	neurodegenerative	ADJ
gs-3960	523	13	processes	process	NOUN
gs-3960	523	14	,	,	PUNCT
gs-3960	523	15	the	the	DET
gs-3960	523	16	following	follow	VERB
gs-3960	523	17	recommendations	recommendation	NOUN
gs-3960	523	18	are	be	AUX
gs-3960	523	19	proposed	propose	VERB
gs-3960	523	20	to	to	PART
gs-3960	523	21	guide	guide	VERB
gs-3960	523	22	scientific	scientific	ADJ
gs-3960	523	23	inquiry	inquiry	NOUN
gs-3960	523	24	,	,	PUNCT
gs-3960	523	25	clinical	clinical	ADJ
gs-3960	523	26	translation	translation	NOUN
gs-3960	523	27	,	,	PUNCT
gs-3960	523	28	and	and	CCONJ
gs-3960	523	29	interdisciplinary	interdisciplinary	ADJ
gs-3960	523	30	collaboration	collaboration	NOUN
gs-3960	523	31	.	.	PUNCT
gs-3960	524	1	fundamental	fundamental	ADJ
gs-3960	524	2	research	research	NOUN
gs-3960	524	3	priorities	priority	NOUN
gs-3960	524	4	a	a	DET
gs-3960	524	5	deeper	deep	ADJ
gs-3960	524	6	exploration	exploration	NOUN
gs-3960	524	7	of	of	ADP
gs-3960	524	8	mitochondrial	mitochondrial	ADJ
gs-3960	524	9	heterogeneity	heterogeneity	NOUN
gs-3960	524	10	across	across	ADP
gs-3960	524	11	neuronal	neuronal	ADJ
gs-3960	524	12	subtypes	subtype	NOUN
gs-3960	524	13	is	be	AUX
gs-3960	524	14	essential	essential	ADJ
gs-3960	524	15	to	to	PART
gs-3960	524	16	elucidate	elucidate	VERB
gs-3960	524	17	why	why	SCONJ
gs-3960	524	18	certain	certain	ADJ
gs-3960	524	19	dopaminergic	dopaminergic	ADJ
gs-3960	524	20	populations	population	NOUN
gs-3960	524	21	exhibit	exhibit	VERB
gs-3960	524	22	heightened	heighten	VERB
gs-3960	524	23	employed	employ	VERB
gs-3960	524	24	to	to	PART
gs-3960	524	25	characterize	characterize	VERB
gs-3960	524	26	mitochondrial	mitochondrial	ADJ
gs-3960	524	27	gene	gene	NOUN
gs-3960	524	28	expression	expression	NOUN
gs-3960	524	29	,	,	PUNCT
gs-3960	524	30	proteomic	proteomic	ADJ
gs-3960	524	31	signatures	signature	NOUN
gs-3960	524	32	,	,	PUNCT
gs-3960	524	33	and	and	CCONJ
gs-3960	524	34	georgian	georgian	PROPN
gs-3960	524	35	scientists/	scientists/	NUM
gs-3960	524	36	.	.	PUNCT
gs-3960	525	1	7	7	NUM
gs-3960	525	2	n	n	PRON
gs-3960	525	3	3	3	NUM
gs-3960	525	4	,	,	PUNCT
gs-3960	525	5	2025	2025	NUM
gs-3960	525	6	432	432	NUM
gs-3960	525	7	metabolic	metabolic	NOUN
gs-3960	525	8	flux	flux	NOUN
gs-3960	525	9	in	in	ADP
gs-3960	525	10	selectively	selectively	ADV
gs-3960	525	11	resistant	resistant	ADJ
gs-3960	525	12	versus	versus	ADP
gs-3960	525	13	vulnerable	vulnerable	ADJ
gs-3960	525	14	neurons	neuron	NOUN
gs-3960	525	15	.	.	PUNCT
gs-3960	526	1	this	this	DET
gs-3960	526	2	line	line	NOUN
gs-3960	526	3	of	of	ADP
gs-3960	526	4	inquiry	inquiry	NOUN
gs-3960	526	5	may	may	AUX
gs-3960	526	6	reveal	reveal	VERB
gs-3960	526	7	endogenous	endogenous	ADJ
gs-3960	526	8	protective	protective	ADJ
gs-3960	526	9	mechanisms	mechanism	NOUN
gs-3960	526	10	that	that	PRON
gs-3960	526	11	could	could	AUX
gs-3960	526	12	be	be	AUX
gs-3960	526	13	therapeutically	therapeutically	ADV
gs-3960	526	14	harnessed	harness	VERB
gs-3960	526	15	.	.	PUNCT
gs-3960	527	1	the	the	DET
gs-3960	527	2	role	role	NOUN
gs-3960	527	3	of	of	ADP
gs-3960	527	4	mitochondrial	mitochondrial	ADJ
gs-3960	527	5	-	-	PUNCT
gs-3960	527	6	nuclear	nuclear	ADJ
gs-3960	527	7	crosstalk	crosstalk	NOUN
gs-3960	527	8	in	in	ADP
gs-3960	527	9	maintaining	maintain	VERB
gs-3960	527	10	neuronal	neuronal	ADJ
gs-3960	527	11	homeostasis	homeostasis	NOUN
gs-3960	527	12	warrants	warrant	NOUN
gs-3960	527	13	systematic	systematic	ADJ
gs-3960	527	14	investigation	investigation	NOUN
gs-3960	527	15	.	.	PUNCT
gs-3960	528	1	given	give	VERB
gs-3960	528	2	that	that	DET
gs-3960	528	3	mitochondrial	mitochondrial	ADJ
gs-3960	528	4	dysfunction	dysfunction	NOUN
gs-3960	528	5	can	can	AUX
gs-3960	528	6	induce	induce	VERB
gs-3960	528	7	widespread	widespread	ADJ
gs-3960	528	8	changes	change	NOUN
gs-3960	528	9	in	in	ADP
gs-3960	528	10	nuclear	nuclear	ADJ
gs-3960	528	11	gene	gene	NOUN
gs-3960	528	12	expression	expression	NOUN
gs-3960	528	13	through	through	ADP
gs-3960	528	14	retrograde	retrograde	ADJ
gs-3960	528	15	signaling	signal	VERB
gs-3960	528	16	pathways	pathway	NOUN
gs-3960	528	17	,	,	PUNCT
gs-3960	528	18	studies	study	NOUN
gs-3960	528	19	should	should	AUX
gs-3960	528	20	focus	focus	VERB
gs-3960	528	21	on	on	ADP
gs-3960	528	22	identifying	identify	VERB
gs-3960	528	23	key	key	ADJ
gs-3960	528	24	transcriptional	transcriptional	ADJ
gs-3960	528	25	regulators	regulator	NOUN
gs-3960	528	26	that	that	PRON
gs-3960	528	27	mediate	mediate	VERB
gs-3960	528	28	these	these	DET
gs-3960	528	29	adaptive	adaptive	ADJ
gs-3960	528	30	responses	response	NOUN
gs-3960	528	31	.	.	PUNCT
gs-3960	529	1	epigenetic	epigenetic	ADJ
gs-3960	529	2	modifications	modification	NOUN
gs-3960	529	3	arising	arise	VERB
gs-3960	529	4	from	from	ADP
gs-3960	529	5	mitochondrial	mitochondrial	ADJ
gs-3960	529	6	stress	stress	NOUN
gs-3960	529	7	,	,	PUNCT
gs-3960	529	8	particularly	particularly	ADV
gs-3960	529	9	those	those	PRON
gs-3960	529	10	affecting	affect	VERB
gs-3960	529	11	chromatin	chromatin	NOUN
gs-3960	529	12	accessibility	accessibility	NOUN
gs-3960	529	13	in	in	ADP
gs-3960	529	14	neurodegeneration	neurodegeneration	NOUN
gs-3960	529	15	-	-	PUNCT
gs-3960	529	16	related	relate	VERB
gs-3960	529	17	genes	gene	NOUN
gs-3960	529	18	,	,	PUNCT
gs-3960	529	19	represent	represent	VERB
gs-3960	529	20	a	a	DET
gs-3960	529	21	critical	critical	ADJ
gs-3960	529	22	area	area	NOUN
gs-3960	529	23	for	for	ADP
gs-3960	529	24	exploration	exploration	NOUN
gs-3960	529	25	.	.	PUNCT
gs-3960	530	1	advanced	advanced	ADJ
gs-3960	530	2	model	model	NOUN
gs-3960	530	3	systems	system	NOUN
gs-3960	530	4	and	and	CCONJ
gs-3960	530	5	methodological	methodological	ADJ
gs-3960	530	6	innovations	innovation	NOUN
gs-3960	530	7	the	the	DET
gs-3960	530	8	development	development	NOUN
gs-3960	530	9	of	of	ADP
gs-3960	530	10	more	more	ADV
gs-3960	530	11	physiologically	physiologically	ADV
gs-3960	530	12	relevant	relevant	ADJ
gs-3960	530	13	experimental	experimental	ADJ
gs-3960	530	14	models	model	NOUN
gs-3960	530	15	is	be	AUX
gs-3960	530	16	paramount	paramount	ADJ
gs-3960	530	17	.	.	PUNCT
gs-3960	531	1	cerebral	cerebral	ADJ
gs-3960	531	2	organoid	organoid	PROPN
gs-3960	531	3	systems	system	NOUN
gs-3960	531	4	incorporating	incorporate	VERB
gs-3960	531	5	patient	patient	NOUN
gs-3960	531	6	-	-	PUNCT
gs-3960	531	7	derived	derive	VERB
gs-3960	531	8	cells	cell	NOUN
gs-3960	531	9	with	with	ADP
gs-3960	531	10	defined	define	VERB
gs-3960	531	11	genetic	genetic	ADJ
gs-3960	531	12	backgrounds	background	NOUN
gs-3960	531	13	should	should	AUX
gs-3960	531	14	be	be	AUX
gs-3960	531	15	optimized	optimize	VERB
gs-3960	531	16	to	to	PART
gs-3960	531	17	recapitulate	recapitulate	VERB
gs-3960	531	18	the	the	DET
gs-3960	531	19	spatial	spatial	ADJ
gs-3960	531	20	and	and	CCONJ
gs-3960	531	21	functional	functional	ADJ
gs-3960	531	22	organization	organization	NOUN
gs-3960	531	23	of	of	ADP
gs-3960	531	24	nigrostriatal	nigrostriatal	ADJ
gs-3960	531	25	circuitry	circuitry	NOUN
gs-3960	531	26	.	.	PUNCT
gs-3960	532	1	these	these	DET
gs-3960	532	2	models	model	NOUN
gs-3960	532	3	must	must	AUX
gs-3960	532	4	integrate	integrate	VERB
gs-3960	532	5	glial	glial	ADJ
gs-3960	532	6	cells	cell	NOUN
gs-3960	532	7	and	and	CCONJ
gs-3960	532	8	vascular	vascular	ADJ
gs-3960	532	9	components	component	NOUN
gs-3960	532	10	to	to	PART
gs-3960	532	11	properly	properly	ADV
gs-3960	532	12	assess	assess	VERB
gs-3960	532	13	neuron	neuron	NOUN
gs-3960	532	14	-	-	PUNCT
gs-3960	532	15	glia	glia	PROPN
gs-3960	532	16	metabolic	metabolic	NOUN
gs-3960	532	17	coupling	coupling	NOUN
gs-3960	532	18	and	and	CCONJ
gs-3960	532	19	its	its	PRON
gs-3960	532	20	failure	failure	NOUN
gs-3960	532	21	in	in	ADP
gs-3960	532	22	super	super	ADJ
gs-3960	532	23	-	-	ADJ
gs-3960	532	24	resolution	resolution	ADJ
gs-3960	532	25	imaging	imaging	NOUN
gs-3960	532	26	modalities	modality	NOUN
gs-3960	532	27	capable	capable	ADJ
gs-3960	532	28	of	of	ADP
gs-3960	532	29	capturing	capture	VERB
gs-3960	532	30	mitochondrial	mitochondrial	ADJ
gs-3960	532	31	dynamics	dynamic	NOUN
gs-3960	532	32	in	in	ADP
gs-3960	532	33	real	real	ADJ
gs-3960	532	34	time	time	NOUN
gs-3960	532	35	should	should	AUX
gs-3960	532	36	be	be	AUX
gs-3960	532	37	combined	combine	VERB
gs-3960	532	38	with	with	ADP
gs-3960	532	39	spatially	spatially	ADV
gs-3960	532	40	resolved	resolve	VERB
gs-3960	532	41	transcriptomics	transcriptomic	NOUN
gs-3960	532	42	to	to	PART
gs-3960	532	43	map	map	VERB
gs-3960	532	44	subcellular	subcellular	ADJ
gs-3960	532	45	patterns	pattern	NOUN
gs-3960	532	46	of	of	ADP
gs-3960	532	47	gene	gene	NOUN
gs-3960	532	48	expression	expression	NOUN
gs-3960	532	49	within	within	ADP
gs-3960	532	50	vulnerable	vulnerable	ADJ
gs-3960	532	51	neuronal	neuronal	ADJ
gs-3960	532	52	compartments	compartment	NOUN
gs-3960	532	53	.	.	PUNCT
gs-3960	533	1	correlative	correlative	ADJ
gs-3960	533	2	light	light	NOUN
gs-3960	533	3	and	and	CCONJ
gs-3960	533	4	electron	electron	NOUN
gs-3960	533	5	microscopy	microscopy	NOUN
gs-3960	533	6	approaches	approach	NOUN
gs-3960	533	7	could	could	AUX
gs-3960	533	8	bridge	bridge	VERB
gs-3960	533	9	the	the	DET
gs-3960	533	10	gap	gap	NOUN
gs-3960	533	11	between	between	ADP
gs-3960	533	12	functional	functional	ADJ
gs-3960	533	13	imaging	imaging	NOUN
gs-3960	533	14	and	and	CCONJ
gs-3960	533	15	ultrastructural	ultrastructural	ADJ
gs-3960	533	16	analysis	analysis	NOUN
gs-3960	533	17	of	of	ADP
gs-3960	533	18	pathological	pathological	ADJ
gs-3960	533	19	mitochondria	mitochondria	NOUN
gs-3960	533	20	.	.	PUNCT
gs-3960	534	1	therapeutic	therapeutic	ADJ
gs-3960	534	2	development	development	NOUN
gs-3960	534	3	and	and	CCONJ
gs-3960	534	4	target	target	VERB
gs-3960	534	5	validation	validation	NOUN
gs-3960	534	6	therapeutic	therapeutic	ADJ
gs-3960	534	7	strategies	strategy	NOUN
gs-3960	534	8	should	should	AUX
gs-3960	534	9	move	move	VERB
gs-3960	534	10	beyond	beyond	ADP
gs-3960	534	11	generic	generic	ADJ
gs-3960	534	12	mitochondrial	mitochondrial	ADJ
gs-3960	534	13	support	support	NOUN
gs-3960	534	14	and	and	CCONJ
gs-3960	534	15	instead	instead	ADV
gs-3960	534	16	target	target	VERB
gs-3960	534	17	specific	specific	ADJ
gs-3960	534	18	pathological	pathological	ADJ
gs-3960	534	19	mechanisms	mechanism	NOUN
gs-3960	534	20	.	.	PUNCT
gs-3960	535	1	small	small	ADJ
gs-3960	535	2	molecule	molecule	NOUN
gs-3960	535	3	screens	screen	NOUN
gs-3960	535	4	ought	ought	AUX
gs-3960	535	5	to	to	PART
gs-3960	535	6	focus	focus	VERB
gs-3960	535	7	on	on	ADP
gs-3960	535	8	compounds	compound	NOUN
gs-3960	535	9	capable	capable	ADJ
gs-3960	535	10	of	of	ADP
gs-3960	535	11	stabilizing	stabilize	VERB
gs-3960	535	12	the	the	DET
gs-3960	535	13	mitochondrial	mitochondrial	ADJ
gs-3960	535	14	protein	protein	NOUN
gs-3960	535	15	import	import	NOUN
gs-3960	535	16	machinery	machinery	NOUN
gs-3960	535	17	or	or	CCONJ
gs-3960	535	18	rescuing	rescue	VERB
gs-3960	535	19	the	the	DET
gs-3960	535	20	assembly	assembly	NOUN
gs-3960	535	21	of	of	ADP
gs-3960	535	22	respiratory	respiratory	ADJ
gs-3960	535	23	supercomplexes	supercomplexe	NOUN
gs-3960	535	24	.	.	PUNCT
gs-3960	536	1	pharmacological	pharmacological	ADJ
gs-3960	536	2	chaperones	chaperone	NOUN
gs-3960	536	3	that	that	PRON
gs-3960	536	4	correct	correct	VERB
gs-3960	536	5	misfolding	misfolding	NOUN
gs-3960	536	6	of	of	ADP
gs-3960	536	7	mitochondrial	mitochondrial	ADJ
gs-3960	536	8	membrane	membrane	NOUN
gs-3960	536	9	proteins	protein	NOUN
gs-3960	536	10	may	may	AUX
gs-3960	536	11	offer	offer	VERB
gs-3960	536	12	particular	particular	ADJ
gs-3960	536	13	promise	promise	NOUN
gs-3960	536	14	given	give	VERB
gs-3960	536	15	the	the	DET
gs-3960	536	16	emerging	emerge	VERB
gs-3960	536	17	understanding	understanding	NOUN
gs-3960	536	18	of	of	ADP
gs-3960	536	19	lipid	lipid	NOUN
gs-3960	536	20	-	-	PUNCT
gs-3960	536	21	protein	protein	NOUN
gs-3960	536	22	interactions	interaction	NOUN
gs-3960	536	23	in	in	ADP
gs-3960	536	24	mitochondrial	mitochondrial	ADJ
gs-3960	536	25	membranes	membrane	NOUN
gs-3960	536	26	.	.	PUNCT
gs-3960	537	1	gene	gene	NOUN
gs-3960	537	2	therapy	therapy	NOUN
gs-3960	537	3	approaches	approach	NOUN
gs-3960	537	4	require	require	VERB
gs-3960	537	5	refinement	refinement	NOUN
gs-3960	537	6	to	to	PART
gs-3960	537	7	achieve	achieve	VERB
gs-3960	537	8	cell	cell	NOUN
gs-3960	537	9	-	-	PUNCT
gs-3960	537	10	type	type	NOUN
gs-3960	537	11	-	-	PUNCT
gs-3960	537	12	specific	specific	ADJ
gs-3960	537	13	delivery	delivery	NOUN
gs-3960	537	14	and	and	CCONJ
gs-3960	537	15	sustained	sustained	ADJ
gs-3960	537	16	expression	expression	NOUN
gs-3960	537	17	of	of	ADP
gs-3960	537	18	mitochondrial	mitochondrial	ADJ
gs-3960	537	19	quality	quality	NOUN
gs-3960	537	20	control	control	NOUN
gs-3960	537	21	factors	factor	NOUN
gs-3960	537	22	.	.	PUNCT
gs-3960	538	1	the	the	DET
gs-3960	538	2	development	development	NOUN
gs-3960	538	3	of	of	ADP
gs-3960	538	4	novel	novel	ADJ
gs-3960	538	5	aav	aav	NOUN
gs-3960	538	6	serotypes	serotype	NOUN
gs-3960	538	7	with	with	ADP
gs-3960	538	8	enhanced	enhanced	ADJ
gs-3960	538	9	tropism	tropism	NOUN
gs-3960	538	10	for	for	ADP
gs-3960	538	11	dopaminergic	dopaminergic	ADJ
gs-3960	538	12	neurons	neuron	NOUN
gs-3960	538	13	and	and	CCONJ
gs-3960	538	14	engineered	engineer	VERB
gs-3960	538	15	mitochondrial	mitochondrial	ADJ
gs-3960	538	16	targeting	target	VERB
gs-3960	538	17	sequences	sequence	NOUN
gs-3960	538	18	could	could	AUX
gs-3960	538	19	significantly	significantly	ADV
gs-3960	538	20	improve	improve	VERB
gs-3960	538	21	the	the	DET
gs-3960	538	22	efficacy	efficacy	NOUN
gs-3960	538	23	of	of	ADP
gs-3960	538	24	such	such	ADJ
gs-3960	538	25	interventions	intervention	NOUN
gs-3960	538	26	.	.	PUNCT
gs-3960	539	1	simultaneously	simultaneously	ADV
gs-3960	539	2	,	,	PUNCT
gs-3960	539	3	antisense	antisense	NOUN
gs-3960	539	4	oligonucleotide	oligonucleotide	NOUN
gs-3960	539	5	strategies	strategy	NOUN
gs-3960	539	6	should	should	AUX
gs-3960	539	7	be	be	AUX
gs-3960	539	8	explored	explore	VERB
gs-3960	539	9	to	to	PART
gs-3960	539	10	modulate	modulate	VERB
gs-3960	539	11	the	the	DET
gs-3960	539	12	mitochondrial	mitochondrial	ADJ
gs-3960	539	13	epitranscriptome	epitranscriptome	NOUN
gs-3960	539	14	and	and	CCONJ
gs-3960	539	15	correct	correct	ADJ
gs-3960	539	16	imbalances	imbalance	NOUN
gs-3960	539	17	in	in	ADP
gs-3960	539	18	respiratory	respiratory	ADJ
gs-3960	539	19	chain	chain	NOUN
gs-3960	539	20	subunit	subunit	NOUN
gs-3960	539	21	expression	expression	NOUN
gs-3960	539	22	.	.	PUNCT
gs-3960	540	1	clinical	clinical	ADJ
gs-3960	540	2	translation	translation	NOUN
gs-3960	540	3	and	and	CCONJ
gs-3960	540	4	trial	trial	NOUN
gs-3960	540	5	design	design	NOUN
gs-3960	540	6	georgian	georgian	NOUN
gs-3960	540	7	scientists/	scientists/	NUM
gs-3960	540	8	.	.	PUNCT
gs-3960	541	1	7	7	NUM
gs-3960	541	2	n	n	PRON
gs-3960	541	3	3	3	NUM
gs-3960	541	4	,	,	PUNCT
gs-3960	541	5	2025	2025	NUM
gs-3960	541	6	433	433	NUM
gs-3960	541	7	future	future	ADJ
gs-3960	541	8	clinical	clinical	ADJ
gs-3960	541	9	trials	trial	NOUN
gs-3960	541	10	must	must	AUX
gs-3960	541	11	incorporate	incorporate	VERB
gs-3960	541	12	advanced	advanced	ADJ
gs-3960	541	13	stratification	stratification	NOUN
gs-3960	541	14	methods	method	NOUN
gs-3960	541	15	to	to	PART
gs-3960	541	16	identify	identify	VERB
gs-3960	541	17	patient	patient	ADJ
gs-3960	541	18	subgroups	subgroup	NOUN
gs-3960	541	19	most	most	ADV
gs-3960	541	20	likely	likely	ADJ
gs-3960	541	21	to	to	PART
gs-3960	541	22	benefit	benefit	VERB
gs-3960	541	23	from	from	ADP
gs-3960	541	24	mitochondrial	mitochondrial	ADJ
gs-3960	541	25	-	-	PUNCT
gs-3960	541	26	targeted	target	VERB
gs-3960	541	27	therapies	therapy	NOUN
gs-3960	541	28	.	.	PUNCT
gs-3960	542	1	deep	deep	ADJ
gs-3960	542	2	phenotyping	phenotype	VERB
gs-3960	542	3	using	use	VERB
gs-3960	542	4	mitochondrial	mitochondrial	ADJ
gs-3960	542	5	functional	functional	ADJ
gs-3960	542	6	assays	assay	NOUN
gs-3960	542	7	in	in	ADP
gs-3960	542	8	peripheral	peripheral	ADJ
gs-3960	542	9	cells	cell	NOUN
gs-3960	542	10	,	,	PUNCT
gs-3960	542	11	combined	combine	VERB
gs-3960	542	12	with	with	ADP
gs-3960	542	13	metabolomic	metabolomic	ADJ
gs-3960	542	14	profiling	profiling	NOUN
gs-3960	542	15	and	and	CCONJ
gs-3960	542	16	brain	brain	NOUN
gs-3960	542	17	imaging	imaging	NOUN
gs-3960	542	18	of	of	ADP
gs-3960	542	19	mitochondrial	mitochondrial	ADJ
gs-3960	542	20	networks	network	NOUN
gs-3960	542	21	,	,	PUNCT
gs-3960	542	22	should	should	AUX
gs-3960	542	23	be	be	AUX
gs-3960	542	24	employed	employ	VERB
gs-3960	542	25	to	to	PART
gs-3960	542	26	establish	establish	VERB
gs-3960	542	27	predictive	predictive	ADJ
gs-3960	542	28	biomarkers	biomarker	NOUN
gs-3960	542	29	of	of	ADP
gs-3960	542	30	treatment	treatment	NOUN
gs-3960	542	31	response	response	NOUN
gs-3960	542	32	.	.	PUNCT
gs-3960	543	1	adaptive	adaptive	ADJ
gs-3960	543	2	trial	trial	NOUN
gs-3960	543	3	designs	design	NOUN
gs-3960	543	4	that	that	PRON
gs-3960	543	5	permit	permit	VERB
gs-3960	543	6	evaluation	evaluation	NOUN
gs-3960	543	7	of	of	ADP
gs-3960	543	8	multiple	multiple	ADJ
gs-3960	543	9	therapeutic	therapeutic	ADJ
gs-3960	543	10	combinations	combination	NOUN
gs-3960	543	11	are	be	AUX
gs-3960	543	12	needed	need	VERB
gs-3960	543	13	to	to	PART
gs-3960	543	14	address	address	VERB
gs-3960	543	15	the	the	DET
gs-3960	543	16	multifactorial	multifactorial	ADJ
gs-3960	543	17	nature	nature	NOUN
gs-3960	543	18	of	of	ADP
gs-3960	543	19	mitochondrial	mitochondrial	ADJ
gs-3960	543	20	dysfunction	dysfunction	NOUN
gs-3960	543	21	.	.	PUNCT
gs-3960	544	1	these	these	DET
gs-3960	544	2	trials	trial	NOUN
gs-3960	544	3	should	should	AUX
gs-3960	544	4	incorporate	incorporate	VERB
gs-3960	544	5	sensitive	sensitive	ADJ
gs-3960	544	6	clinical	clinical	ADJ
gs-3960	544	7	endpoints	endpoint	NOUN
gs-3960	544	8	beyond	beyond	ADP
gs-3960	544	9	motor	motor	NOUN
gs-3960	544	10	symptoms	symptom	NOUN
gs-3960	544	11	,	,	PUNCT
gs-3960	544	12	including	include	VERB
gs-3960	544	13	measures	measure	NOUN
gs-3960	544	14	of	of	ADP
gs-3960	544	15	autonomic	autonomic	ADJ
gs-3960	544	16	function	function	NOUN
gs-3960	544	17	and	and	CCONJ
gs-3960	544	18	cognitive	cognitive	ADJ
gs-3960	544	19	performance	performance	NOUN
gs-3960	544	20	that	that	PRON
gs-3960	544	21	may	may	AUX
gs-3960	544	22	reflect	reflect	VERB
gs-3960	544	23	systemic	systemic	ADJ
gs-3960	544	24	mitochondrial	mitochondrial	ADJ
gs-3960	544	25	impairment	impairment	NOUN
gs-3960	544	26	.	.	PUNCT
gs-3960	545	1	the	the	DET
gs-3960	545	2	development	development	NOUN
gs-3960	545	3	of	of	ADP
gs-3960	545	4	standardized	standardized	ADJ
gs-3960	545	5	protocols	protocol	NOUN
gs-3960	545	6	for	for	ADP
gs-3960	545	7	assessing	assess	VERB
gs-3960	545	8	mitochondrial	mitochondrial	ADJ
gs-3960	545	9	function	function	NOUN
gs-3960	545	10	in	in	ADP
gs-3960	545	11	clinical	clinical	ADJ
gs-3960	545	12	samples	sample	NOUN
gs-3960	545	13	will	will	AUX
gs-3960	545	14	be	be	AUX
gs-3960	545	15	essential	essential	ADJ
gs-3960	545	16	for	for	ADP
gs-3960	545	17	cross	cross	ADJ
gs-3960	545	18	-	-	ADJ
gs-3960	545	19	study	study	ADJ
gs-3960	545	20	comparisons	comparison	NOUN
gs-3960	545	21	and	and	CCONJ
gs-3960	545	22	meta	meta	NOUN
gs-3960	545	23	-	-	PUNCT
gs-3960	545	24	analyses	analysis	NOUN
gs-3960	545	25	.	.	PUNCT
gs-3960	546	1	concluding	conclude	VERB
gs-3960	546	2	remarks	remark	VERB
gs-3960	546	3	the	the	DET
gs-3960	546	4	recommendations	recommendation	NOUN
gs-3960	546	5	outlined	outline	VERB
gs-3960	546	6	above	above	ADV
gs-3960	546	7	provide	provide	VERB
gs-3960	546	8	a	a	DET
gs-3960	546	9	framework	framework	NOUN
gs-3960	546	10	for	for	ADP
gs-3960	546	11	advancing	advance	VERB
gs-3960	546	12	relevance	relevance	NOUN
gs-3960	546	13	.	.	PUNCT
gs-3960	547	1	by	by	ADP
gs-3960	547	2	embracing	embrace	VERB
gs-3960	547	3	innovative	innovative	ADJ
gs-3960	547	4	methodologies	methodology	NOUN
gs-3960	547	5	,	,	PUNCT
gs-3960	547	6	fostering	foster	VERB
gs-3960	547	7	interdisciplinary	interdisciplinary	ADJ
gs-3960	547	8	collaboration	collaboration	NOUN
gs-3960	547	9	,	,	PUNCT
gs-3960	547	10	and	and	CCONJ
gs-3960	547	11	maintaining	maintain	VERB
gs-3960	547	12	focus	focus	NOUN
gs-3960	547	13	on	on	ADP
gs-3960	547	14	mechanistic	mechanistic	ADJ
gs-3960	547	15	depth	depth	NOUN
gs-3960	547	16	,	,	PUNCT
gs-3960	547	17	the	the	DET
gs-3960	547	18	scientific	scientific	ADJ
gs-3960	547	19	community	community	NOUN
gs-3960	547	20	can	can	AUX
gs-3960	547	21	accelerate	accelerate	VERB
gs-3960	547	22	progress	progress	NOUN
gs-3960	547	23	toward	toward	ADP
gs-3960	547	24	meaningful	meaningful	ADJ
gs-3960	547	25	therapeutic	therapeutic	ADJ
gs-3960	547	26	breakthroughs	breakthrough	NOUN
gs-3960	547	27	.	.	PUNCT
gs-3960	548	1	the	the	DET
gs-3960	548	2	complexity	complexity	NOUN
gs-3960	548	3	of	of	ADP
gs-3960	548	4	mitochondrial	mitochondrial	ADJ
gs-3960	548	5	pathophysiology	pathophysiology	NOUN
gs-3960	548	6	demands	demand	NOUN
gs-3960	548	7	sustained	sustain	VERB
gs-3960	548	8	investment	investment	NOUN
gs-3960	548	9	and	and	CCONJ
gs-3960	548	10	intellectual	intellectual	ADJ
gs-3960	548	11	exploratory	exploratory	ADJ
gs-3960	548	12	science	science	NOUN
gs-3960	548	13	with	with	ADP
gs-3960	548	14	disciplined	discipline	VERB
gs-3960	548	15	validation	validation	NOUN
gs-3960	548	16	,	,	PUNCT
gs-3960	548	17	always	always	ADV
gs-3960	548	18	anchoring	anchor	VERB
gs-3960	548	19	investigations	investigation	NOUN
gs-3960	548	20	in	in	ADP
gs-3960	548	21	their	their	PRON
gs-3960	548	22	ultimate	ultimate	ADJ
gs-3960	548	23	relevance	relevance	NOUN
gs-3960	548	24	to	to	PART
gs-3960	548	25	patient	patient	VERB
gs-3960	548	26	outcomes	outcome	NOUN
gs-3960	548	27	.	.	PUNCT
gs-3960	549	1	through	through	ADP
gs-3960	549	2	coordinated	coordinate	VERB
gs-3960	549	3	global	global	ADJ
gs-3960	549	4	efforts	effort	NOUN
gs-3960	549	5	that	that	PRON
gs-3960	549	6	leverage	leverage	VERB
gs-3960	549	7	cutting	cutting	NOUN
gs-3960	549	8	-	-	PUNCT
gs-3960	549	9	edge	edge	NOUN
gs-3960	549	10	technologies	technology	NOUN
gs-3960	549	11	and	and	CCONJ
gs-3960	549	12	deep	deep	ADJ
gs-3960	549	13	biological	biological	ADJ
gs-3960	549	14	insight	insight	NOUN
gs-3960	549	15	,	,	PUNCT
gs-3960	549	16	the	the	DET
gs-3960	549	17	field	field	NOUN
gs-3960	549	18	can	can	AUX
gs-3960	549	19	transform	transform	VERB
gs-3960	549	20	our	our	PRON
gs-3960	549	21	understanding	understanding	NOUN
gs-3960	549	22	of	of	ADP
gs-3960	549	23	mitochondrial	mitochondrial	ADJ
gs-3960	549	24	medicine	medicine	NOUN
gs-3960	549	25	in	in	ADP
gs-3960	549	26	neurodegeneration	neurodegeneration	NOUN
gs-3960	549	27	.	.	PUNCT
gs-3960	550	1	funding	funding	NOUN
gs-3960	550	2	:	:	PUNCT
gs-3960	550	3	this	this	DET
gs-3960	550	4	research	research	NOUN
gs-3960	550	5	received	receive	VERB
gs-3960	550	6	no	no	DET
gs-3960	550	7	external	external	ADJ
gs-3960	550	8	funding	funding	NOUN
gs-3960	550	9	.	.	PUNCT
gs-3960	551	1	conflicts	conflict	NOUN
gs-3960	551	2	of	of	ADP
gs-3960	551	3	interest	interest	NOUN
gs-3960	551	4	:	:	PUNCT
gs-3960	551	5	the	the	DET
gs-3960	551	6	authors	author	NOUN
gs-3960	551	7	declare	declare	VERB
gs-3960	551	8	no	no	DET
gs-3960	551	9	conflicts	conflict	NOUN
gs-3960	551	10	of	of	ADP
gs-3960	551	11	interest	interest	NOUN
gs-3960	551	12	.	.	PUNCT
gs-3960	552	1	financial	financial	ADJ
gs-3960	552	2	disclosure	disclosure	NOUN
gs-3960	552	3	statement	statement	NOUN
gs-3960	552	4	:	:	PUNCT
gs-3960	552	5	the	the	DET
gs-3960	552	6	authors	author	NOUN
gs-3960	552	7	declare	declare	VERB
gs-3960	552	8	no	no	DET
gs-3960	552	9	financial	financial	ADJ
gs-3960	552	10	support	support	NOUN
gs-3960	552	11	,	,	PUNCT
gs-3960	552	12	funding	funding	NOUN
gs-3960	552	13	,	,	PUNCT
gs-3960	552	14	or	or	CCONJ
gs-3960	552	15	conflicts	conflict	NOUN
gs-3960	552	16	of	of	ADP
gs-3960	552	17	interest	interest	NOUN
gs-3960	552	18	related	relate	VERB
gs-3960	552	19	to	to	ADP
gs-3960	552	20	this	this	DET
gs-3960	552	21	work	work	NOUN
gs-3960	552	22	.	.	PUNCT
gs-3960	553	1	georgian	georgian	NOUN
gs-3960	553	2	scientists/	scientists/	NUM
gs-3960	553	3	.	.	PUNCT
gs-3960	554	1	7	7	NUM
gs-3960	554	2	n	n	PRON
gs-3960	554	3	3	3	NUM
gs-3960	554	4	,	,	PUNCT
gs-3960	554	5	2025	2025	NUM
gs-3960	554	6	434	434	NUM
gs-3960	554	7	references	reference	NOUN
gs-3960	554	8	1	1	NUM
gs-3960	554	9	.	.	PUNCT
gs-3960	554	10	exner	exner	PROPN
gs-3960	554	11	n	n	PROPN
gs-3960	554	12	,	,	PUNCT
gs-3960	554	13	lutz	lutz	PROPN
gs-3960	554	14	ak	ak	PROPN
gs-3960	554	15	,	,	PUNCT
gs-3960	554	16	haass	haass	VERB
gs-3960	554	17	c	c	NOUN
gs-3960	554	18	,	,	PUNCT
gs-3960	554	19	winklhofer	winklhofer	PROPN
gs-3960	554	20	kf	kf	PROPN
gs-3960	554	21	.	.	PUNCT
gs-3960	555	1	mitochondrial	mitochondrial	ADJ
gs-3960	555	2	dysfunction	dysfunction	NOUN
gs-3960	555	3	in	in	ADP
gs-3960	555	4	parkinson	parkinson	NOUN
gs-3960	555	5	's	's	PART
gs-3960	555	6	disease	disease	NOUN
gs-3960	555	7	:	:	PUNCT
gs-3960	555	8	molecular	molecular	ADJ
gs-3960	555	9	mechanisms	mechanism	NOUN
gs-3960	555	10	and	and	CCONJ
gs-3960	555	11	pathophysiological	pathophysiological	ADJ
gs-3960	555	12	consequences	consequence	NOUN
gs-3960	555	13	.	.	PUNCT
gs-3960	556	1	2	2	X
gs-3960	556	2	.	.	X
gs-3960	556	3	youle	youle	PROPN
gs-3960	556	4	rj	rj	PROPN
gs-3960	556	5	,	,	PUNCT
gs-3960	556	6	narendra	narendra	PROPN
gs-3960	556	7	dp	dp	PROPN
gs-3960	556	8	.	.	PROPN
gs-3960	556	9	mechanisms	mechanism	NOUN
gs-3960	556	10	of	of	ADP
gs-3960	556	11	mitophagy	mitophagy	NOUN
gs-3960	556	12	.	.	PUNCT
gs-3960	557	1	nat	nat	PROPN
gs-3960	557	2	rev	rev	VERB
gs-3960	557	3	mol	mol	ADP
gs-3960	557	4	cell	cell	NOUN
gs-3960	557	5	biol	biol	NOUN
gs-3960	557	6	.	.	PUNCT
gs-3960	558	1	3	3	X
gs-3960	558	2	.	.	X
gs-3960	558	3	fang	fang	PROPN
gs-3960	558	4	ef	ef	PROPN
gs-3960	558	5	,	,	PUNCT
gs-3960	558	6	lautrup	lautrup	NOUN
gs-3960	558	7	s	s	PROPN
gs-3960	558	8	,	,	PUNCT
gs-3960	558	9	hou	hou	PROPN
gs-3960	558	10	y	y	PROPN
gs-3960	558	11	,	,	PUNCT
gs-3960	558	12	demarest	demarest	PROPN
gs-3960	558	13	tg	tg	PROPN
gs-3960	558	14	,	,	PUNCT
gs-3960	558	15	croteau	croteau	PROPN
gs-3960	558	16	dl	dl	PROPN
gs-3960	558	17	,	,	PUNCT
gs-3960	558	18	mattson	mattson	PROPN
gs-3960	558	19	mp	mp	PROPN
gs-3960	558	20	,	,	PUNCT
gs-3960	558	21	et	et	PROPN
gs-3960	558	22	al	al	PROPN
gs-3960	558	23	.	.	PUNCT
gs-3960	558	24	nad	nad	PROPN
gs-3960	558	25	in	in	ADP
gs-3960	558	26	aging	age	VERB
gs-3960	558	27	:	:	PUNCT
gs-3960	558	28	molecular	molecular	ADJ
gs-3960	558	29	mechanisms	mechanism	NOUN
gs-3960	558	30	and	and	CCONJ
gs-3960	558	31	translational	translational	ADJ
gs-3960	558	32	implications	implication	NOUN
gs-3960	558	33	.	.	PUNCT
gs-3960	559	1	trends	trend	NOUN
gs-3960	559	2	mol	mol	ADP
gs-3960	559	3	med	med	PROPN
gs-3960	559	4	.	.	PUNCT
gs-3960	560	1	4	4	X
gs-3960	560	2	.	.	X
gs-3960	560	3	wang	wang	PROPN
gs-3960	560	4	w	w	PROPN
gs-3960	560	5	,	,	PUNCT
gs-3960	560	6	zhao	zhao	PROPN
gs-3960	560	7	f	f	PROPN
gs-3960	560	8	,	,	PUNCT
gs-3960	560	9	ma	ma	PROPN
gs-3960	560	10	x	x	PROPN
gs-3960	560	11	,	,	PUNCT
gs-3960	560	12	perry	perry	PROPN
gs-3960	560	13	g	g	PROPN
gs-3960	560	14	,	,	PUNCT
gs-3960	560	15	zhu	zhu	PROPN
gs-3960	560	16	x.	x.	NOUN
gs-3960	560	17	mitochondria	mitochondria	PROPN
gs-3960	560	18	dysfunction	dysfunction	NOUN
gs-3960	560	19	in	in	ADP
gs-3960	560	20	the	the	DET
gs-3960	560	21	2020;15(1):30	2020;15(1):30	NUM
gs-3960	560	22	.	.	PUNCT
gs-3960	561	1	5	5	NUM
gs-3960	561	2	.	.	X
gs-3960	561	3	pickrell	pickrell	PROPN
gs-3960	561	4	am	am	PROPN
gs-3960	561	5	,	,	PUNCT
gs-3960	561	6	youle	youle	PROPN
gs-3960	561	7	rj	rj	PROPN
gs-3960	561	8	.	.	PUNCT
gs-3960	562	1	the	the	DET
gs-3960	562	2	roles	role	NOUN
gs-3960	562	3	of	of	ADP
gs-3960	562	4	pink1	pink1	NOUN
gs-3960	562	5	,	,	PUNCT
gs-3960	562	6	parkin	parkin	NOUN
gs-3960	562	7	,	,	PUNCT
gs-3960	562	8	and	and	CCONJ
gs-3960	562	9	mitochondrial	mitochondrial	ADJ
gs-3960	562	10	fidelity	fidelity	NOUN
gs-3960	562	11	in	in	ADP
gs-3960	562	12	6	6	NUM
gs-3960	562	13	.	.	PUNCT
gs-3960	562	14	neurons	neuron	NOUN
gs-3960	562	15	against	against	ADP
gs-3960	562	16	glutamate	glutamate	NOUN
gs-3960	562	17	-	-	PUNCT
gs-3960	562	18	induced	induce	VERB
gs-3960	562	19	excitotoxicity	excitotoxicity	NOUN
gs-3960	562	20	.	.	PUNCT
gs-3960	563	1	cell	cell	NOUN
gs-3960	563	2	death	death	NOUN
gs-3960	563	3	dis	dis	PROPN
gs-3960	563	4	.	.	PUNCT
gs-3960	564	1	2013;4(1):e455	2013;4(1):e455	INTJ
gs-3960	564	2	.	.	PUNCT
gs-3960	565	1	7	7	X
gs-3960	565	2	.	.	X
gs-3960	565	3	hou	hou	PROPN
gs-3960	565	4	y	y	PROPN
gs-3960	565	5	,	,	PUNCT
gs-3960	565	6	lautrup	lautrup	NOUN
gs-3960	565	7	s	s	PROPN
gs-3960	565	8	,	,	PUNCT
gs-3960	565	9	cordonnier	cordonnier	NOUN
gs-3960	565	10	s	s	PROPN
gs-3960	565	11	,	,	PUNCT
gs-3960	565	12	wang	wang	PROPN
gs-3960	565	13	y	y	PROPN
gs-3960	565	14	,	,	PUNCT
gs-3960	565	15	croteau	croteau	PROPN
gs-3960	565	16	dl	dl	PROPN
gs-3960	565	17	,	,	PUNCT
gs-3960	565	18	zavala	zavala	NOUN
gs-3960	565	19	e	e	NOUN
gs-3960	565	20	,	,	PUNCT
gs-3960	565	21	et	et	PROPN
gs-3960	565	22	al	al	PROPN
gs-3960	565	23	.	.	PUNCT
gs-3960	566	1	nad	nad	ADJ
gs-3960	566	2	supplementation	supplementation	NOUN
gs-3960	566	3	normalizes	normalize	VERB
gs-3960	566	4	key	key	ADJ
gs-3960	566	5	alzheimer	alzheimer	PROPN
gs-3960	566	6	's	's	PART
gs-3960	566	7	features	feature	NOUN
gs-3960	566	8	and	and	CCONJ
gs-3960	566	9	dna	dna	NOUN
gs-3960	566	10	damage	damage	NOUN
gs-3960	566	11	responses	response	NOUN
gs-3960	566	12	in	in	ADP
gs-3960	566	13	a	a	DET
gs-3960	566	14	new	new	ADJ
gs-3960	566	15	ad	ad	NOUN
gs-3960	566	16	mouse	mouse	NOUN
gs-3960	566	17	model	model	NOUN
gs-3960	566	18	with	with	ADP
gs-3960	566	19	introduced	introduce	VERB
gs-3960	566	20	dna	dna	PROPN
gs-3960	566	21	repair	repair	NOUN
gs-3960	566	22	deficiency	deficiency	NOUN
gs-3960	566	23	.	.	PUNCT
gs-3960	567	1	proc	proc	PROPN
gs-3960	567	2	natl	natl	PROPN
gs-3960	567	3	acad	acad	PROPN
gs-3960	567	4	sci	sci	PROPN
gs-3960	567	5	u	u	PROPN
gs-3960	567	6	s	s	PART
gs-3960	567	7	8	8	NUM
gs-3960	567	8	.	.	PUNCT
gs-3960	567	9	narendra	narendra	PROPN
gs-3960	567	10	d	d	PROPN
gs-3960	567	11	,	,	PUNCT
gs-3960	567	12	tanaka	tanaka	PROPN
gs-3960	567	13	a	a	PROPN
gs-3960	567	14	,	,	PUNCT
gs-3960	567	15	suen	suen	PROPN
gs-3960	567	16	df	df	PROPN
gs-3960	567	17	,	,	PUNCT
gs-3960	567	18	youle	youle	PROPN
gs-3960	567	19	rj	rj	PROPN
gs-3960	567	20	.	.	PROPN
gs-3960	567	21	parkin	parkin	PROPN
gs-3960	567	22	is	be	AUX
gs-3960	567	23	recruited	recruit	VERB
gs-3960	567	24	selectively	selectively	ADV
gs-3960	567	25	to	to	ADP
gs-3960	567	26	impaired	impaired	ADJ
gs-3960	567	27	9	9	NUM
gs-3960	567	28	.	.	PUNCT
gs-3960	567	29	lautrup	lautrup	PROPN
gs-3960	567	30	s	s	PROPN
gs-3960	567	31	,	,	PUNCT
gs-3960	567	32	sinclair	sinclair	PROPN
gs-3960	567	33	da	da	PROPN
gs-3960	567	34	,	,	PUNCT
gs-3960	567	35	mattson	mattson	PROPN
gs-3960	567	36	mp	mp	PROPN
gs-3960	567	37	,	,	PUNCT
gs-3960	567	38	fang	fang	PROPN
gs-3960	567	39	ef	ef	PROPN
gs-3960	567	40	.	.	PUNCT
gs-3960	567	41	nad	nad	PROPN
gs-3960	567	42	in	in	ADP
gs-3960	567	43	brain	brain	NOUN
gs-3960	567	44	aging	aging	NOUN
gs-3960	567	45	and	and	CCONJ
gs-3960	567	46	10	10	NUM
gs-3960	567	47	.	.	PUNCT
gs-3960	568	1	pink1	pink1	NOUN
gs-3960	568	2	/	/	SYM
gs-3960	568	3	parkin	parkin	NOUN
gs-3960	568	4	-	-	PUNCT
gs-3960	568	5	mediated	mediate	VERB
gs-3960	568	6	mitophagy	mitophagy	NOUN
gs-3960	568	7	is	be	AUX
gs-3960	568	8	dependent	dependent	ADJ
gs-3960	568	9	on	on	ADP
gs-3960	568	10	vdac1	vdac1	NOUN
gs-3960	568	11	and	and	CCONJ
gs-3960	568	12	p62	p62	NOUN
gs-3960	568	13	/	/	SYM
gs-3960	568	14	sqstm1	sqstm1	NOUN
gs-3960	568	15	.	.	PUNCT
gs-3960	569	1	nat	nat	PROPN
gs-3960	569	2	11	11	NUM
gs-3960	569	3	.	.	PUNCT
gs-3960	570	1	choubey	choubey	NOUN
gs-3960	570	2	v	v	ADP
gs-3960	570	3	,	,	PUNCT
gs-3960	570	4	safiulina	safiulina	PROPN
gs-3960	570	5	d	d	PROPN
gs-3960	570	6	,	,	PUNCT
gs-3960	570	7	vaarmann	vaarmann	PROPN
gs-3960	570	8	a	a	X
gs-3960	570	9	,	,	PUNCT
gs-3960	570	10	cagalinec	cagalinec	PROPN
gs-3960	570	11	m	m	PROPN
gs-3960	570	12	,	,	PUNCT
gs-3960	570	13	wareski	wareski	VERB
gs-3960	570	14	p	p	NOUN
gs-3960	570	15	,	,	PUNCT
gs-3960	570	16	kuum	kuum	PROPN
gs-3960	570	17	m	m	PROPN
gs-3960	570	18	,	,	PUNCT
gs-3960	570	19	et	et	PROPN
gs-3960	570	20	al	al	PROPN
gs-3960	570	21	.	.	PROPN
gs-3960	571	1	mutant	mutant	PROPN
gs-3960	571	2	a53	a53	PROPN
gs-3960	571	3	t	t	PROPN
gs-3960	571	4	-synuclein	-synuclein	PROPN
gs-3960	571	5	induces	induce	VERB
gs-3960	571	6	neuronal	neuronal	ADJ
gs-3960	571	7	death	death	NOUN
gs-3960	571	8	by	by	ADP
gs-3960	571	9	increasing	increase	VERB
gs-3960	571	10	mitochondrial	mitochondrial	ADJ
gs-3960	571	11	12	12	NUM
gs-3960	571	12	.	.	PUNCT
gs-3960	572	1	massudi	massudi	PROPN
gs-3960	572	2	h	h	PROPN
gs-3960	572	3	,	,	PUNCT
gs-3960	572	4	grant	grant	NOUN
gs-3960	572	5	r	r	NOUN
gs-3960	572	6	,	,	PUNCT
gs-3960	572	7	braidy	braidy	VERB
gs-3960	572	8	n	n	SYM
gs-3960	572	9	,	,	PUNCT
gs-3960	572	10	guest	guest	PROPN
gs-3960	572	11	j	j	PROPN
gs-3960	572	12	,	,	PUNCT
gs-3960	572	13	farnsworth	farnsworth	PROPN
gs-3960	572	14	b	b	PROPN
gs-3960	572	15	,	,	PUNCT
gs-3960	572	16	guillemin	guillemin	PROPN
gs-3960	572	17	gj	gj	PROPN
gs-3960	572	18	.	.	PROPN
gs-3960	572	19	ageassociated	ageassociate	VERB
gs-3960	572	20	changes	change	NOUN
gs-3960	572	21	in	in	ADP
gs-3960	572	22	oxidative	oxidative	ADJ
gs-3960	572	23	stress	stress	NOUN
gs-3960	572	24	and	and	CCONJ
gs-3960	572	25	nad	nad	ADJ
gs-3960	572	26	metabolism	metabolism	NOUN
gs-3960	572	27	in	in	ADP
gs-3960	572	28	human	human	ADJ
gs-3960	572	29	tissue	tissue	NOUN
gs-3960	572	30	.	.	PUNCT
gs-3960	573	1	plos	plos	PROPN
gs-3960	573	2	one	one	NUM
gs-3960	573	3	.	.	PUNCT
gs-3960	574	1	2012;7(7):e42357	2012;7(7):e42357	NUM
gs-3960	574	2	.	.	PUNCT
gs-3960	575	1	13	13	NUM
gs-3960	575	2	.	.	X
gs-3960	575	3	ryan	ryan	PROPN
gs-3960	575	4	bj	bj	PROPN
gs-3960	575	5	,	,	PUNCT
gs-3960	575	6	hoek	hoek	PROPN
gs-3960	575	7	s	s	PROPN
gs-3960	575	8	,	,	PUNCT
gs-3960	575	9	fon	fon	PROPN
gs-3960	575	10	ea	ea	PROPN
gs-3960	575	11	,	,	PUNCT
gs-3960	575	12	wade	wade	PROPN
gs-3960	575	13	-	-	PUNCT
gs-3960	575	14	martins	martin	NOUN
gs-3960	575	15	r.	r.	PROPN
gs-3960	575	16	mitochondrial	mitochondrial	ADJ
gs-3960	575	17	dysfunction	dysfunction	NOUN
gs-3960	575	18	and	and	CCONJ
gs-3960	575	19	mitophagy	mitophagy	NOUN
gs-3960	575	20	in	in	ADP
gs-3960	575	21	parkinson	parkinson	NOUN
gs-3960	575	22	's	's	PART
gs-3960	575	23	:	:	PUNCT
gs-3960	575	24	from	from	ADP
gs-3960	575	25	familial	familial	ADJ
gs-3960	575	26	to	to	ADP
gs-3960	575	27	sporadic	sporadic	ADJ
gs-3960	575	28	disease	disease	NOUN
gs-3960	575	29	.	.	PUNCT
gs-3960	576	1	trends	trend	NOUN
gs-3960	576	2	biochem	biochem	PROPN
gs-3960	576	3	sci	sci	PROPN
gs-3960	576	4	.	.	PROPN
gs-3960	577	1	14	14	NUM
gs-3960	577	2	.	.	PUNCT
gs-3960	578	1	katsouri	katsouri	PROPN
gs-3960	578	2	l	l	PROPN
gs-3960	578	3	,	,	PUNCT
gs-3960	578	4	parr	parr	X
gs-3960	578	5	c	c	NOUN
gs-3960	578	6	,	,	PUNCT
gs-3960	578	7	bogdanovic	bogdanovic	PROPN
gs-3960	578	8	n	n	CCONJ
gs-3960	578	9	,	,	PUNCT
gs-3960	578	10	willem	willem	PROPN
gs-3960	578	11	m	m	PROPN
gs-3960	578	12	,	,	PUNCT
gs-3960	578	13	sastre	sastre	NOUN
gs-3960	578	14	m.	m.	NOUN
gs-3960	578	15	ppar	ppar	NOUN
gs-3960	578	16	co	co	NOUN
gs-3960	578	17	-	-	NOUN
gs-3960	578	18	activator	activator	NOUN
gs-3960	578	19	(	(	PUNCT
gs-3960	578	20	pgc-1	pgc-1	PRON
gs-3960	578	21	)	)	PUNCT
gs-3960	578	22	reduces	reduce	VERB
gs-3960	578	23	amyloid	amyloid	NOUN
gs-3960	578	24	generation	generation	NOUN
gs-3960	578	25	through	through	ADP
gs-3960	578	26	a	a	DET
gs-3960	578	27	ppar	ppar	NOUN
gs-3960	578	28	-dependent	-dependent	ADJ
gs-3960	578	29	mechanism	mechanism	NOUN
gs-3960	578	30	.	.	PUNCT
gs-3960	579	1	georgian	georgian	NOUN
gs-3960	579	2	scientists/	scientists/	NUM
gs-3960	579	3	.	.	PUNCT
gs-3960	580	1	7	7	NUM
gs-3960	580	2	n	n	PRON
gs-3960	580	3	3	3	NUM
gs-3960	580	4	,	,	PUNCT
gs-3960	580	5	2025	2025	NUM
gs-3960	580	6	435	435	NUM
gs-3960	580	7	15	15	NUM
gs-3960	580	8	.	.	PUNCT
gs-3960	581	1	clark	clark	PROPN
gs-3960	581	2	j	j	PROPN
gs-3960	581	3	,	,	PUNCT
gs-3960	581	4	reddy	reddy	PROPN
gs-3960	581	5	s	s	PROPN
gs-3960	581	6	,	,	PUNCT
gs-3960	581	7	zheng	zheng	PROPN
gs-3960	581	8	k	k	PROPN
gs-3960	581	9	,	,	PUNCT
gs-3960	581	10	betts	betts	PROPN
gs-3960	581	11	j	j	PROPN
gs-3960	581	12	,	,	PUNCT
gs-3960	581	13	rajput	rajput	PROPN
gs-3960	581	14	a	a	PROPN
gs-3960	581	15	,	,	PUNCT
gs-3960	581	16	betts	betts	PROPN
gs-3960	581	17	h	h	PROPN
gs-3960	581	18	,	,	PUNCT
gs-3960	581	19	et	et	PROPN
gs-3960	581	20	al	al	PROPN
gs-3960	581	21	.	.	PROPN
gs-3960	581	22	association	association	PROPN
gs-3960	581	23	of	of	ADP
gs-3960	581	24	pgc-1	pgc-1	ADJ
gs-3960	581	25	genet	genet	NOUN
gs-3960	581	26	.	.	PUNCT
gs-3960	582	1	2011;12:69	2011;12:69	ADV
gs-3960	582	2	.	.	PUNCT
gs-3960	583	1	16	16	NUM
gs-3960	583	2	.	.	PUNCT
gs-3960	584	1	swerdlow	swerdlow	PROPN
gs-3960	584	2	rh	rh	PROPN
gs-3960	584	3	.	.	PROPN
gs-3960	584	4	mitochondria	mitochondria	PROPN
gs-3960	584	5	and	and	CCONJ
gs-3960	584	6	mitochondrial	mitochondrial	ADJ
gs-3960	584	7	cascades	cascade	NOUN
gs-3960	584	8	in	in	ADP
gs-3960	584	9	alzheimer	alzheimer	PROPN
gs-3960	584	10	's	's	PART
gs-3960	584	11	17	17	NUM
gs-3960	584	12	.	.	PUNCT
gs-3960	585	1	ghosh	ghosh	PROPN
gs-3960	585	2	a	a	PROPN
gs-3960	585	3	,	,	PUNCT
gs-3960	585	4	chandran	chandran	PROPN
gs-3960	585	5	k	k	PROPN
gs-3960	585	6	,	,	PUNCT
gs-3960	585	7	kalivendi	kalivendi	PROPN
gs-3960	585	8	sv	sv	PROPN
gs-3960	585	9	,	,	PUNCT
gs-3960	585	10	joseph	joseph	PROPN
gs-3960	585	11	j	j	PROPN
gs-3960	585	12	,	,	PUNCT
gs-3960	585	13	antholine	antholine	VERB
gs-3960	585	14	we	we	PRON
gs-3960	585	15	,	,	PUNCT
gs-3960	585	16	hillard	hillard	PROPN
gs-3960	585	17	cj	cj	PROPN
gs-3960	585	18	,	,	PUNCT
gs-3960	585	19	et	et	PROPN
gs-3960	585	20	al	al	PROPN
gs-3960	585	21	.	.	PROPN
gs-3960	585	22	neuroprotection	neuroprotection	NOUN
gs-3960	585	23	by	by	ADP
gs-3960	585	24	a	a	DET
gs-3960	585	25	mitochondria	mitochondria	NOUN
gs-3960	585	26	-	-	PUNCT
gs-3960	585	27	targeted	target	VERB
gs-3960	585	28	drug	drug	NOUN
gs-3960	585	29	in	in	ADP
gs-3960	585	30	a	a	DET
gs-3960	585	31	parkinson	parkinson	NOUN
gs-3960	585	32	's	's	PART
gs-3960	585	33	disease	disease	NOUN
gs-3960	585	34	model	model	NOUN
gs-3960	585	35	.	.	PUNCT
gs-3960	586	1	18	18	NUM
gs-3960	586	2	.	.	PUNCT
gs-3960	587	1	shi	shi	PROPN
gs-3960	587	2	t	t	PROPN
gs-3960	587	3	,	,	PUNCT
gs-3960	587	4	wang	wang	PROPN
gs-3960	587	5	f	f	PROPN
gs-3960	587	6	,	,	PUNCT
gs-3960	587	7	stieren	stieren	PROPN
gs-3960	587	8	e	e	NOUN
gs-3960	587	9	,	,	PUNCT
gs-3960	587	10	tong	tong	PROPN
gs-3960	587	11	q.	q.	PROPN
gs-3960	587	12	sirt3	sirt3	PROPN
gs-3960	587	13	,	,	PUNCT
gs-3960	587	14	a	a	DET
gs-3960	587	15	mitochondrial	mitochondrial	ADJ
gs-3960	587	16	sirtuin	sirtuin	NOUN
gs-3960	587	17	deacetylase	deacetylase	NOUN
gs-3960	587	18	,	,	PUNCT
gs-3960	587	19	regulates	regulate	VERB
gs-3960	587	20	mitochondrial	mitochondrial	ADJ
gs-3960	587	21	function	function	NOUN
gs-3960	587	22	and	and	CCONJ
gs-3960	587	23	thermogenesis	thermogenesis	NOUN
gs-3960	587	24	in	in	ADP
gs-3960	587	25	brown	brown	ADJ
gs-3960	587	26	adipocytes	adipocyte	NOUN
gs-3960	587	27	.	.	PUNCT
gs-3960	588	1	j	j	PROPN
gs-3960	588	2	biol	biol	PROPN
gs-3960	588	3	chem	chem	NOUN
gs-3960	588	4	.	.	PUNCT
gs-3960	589	1	19	19	NUM
gs-3960	589	2	.	.	PUNCT
gs-3960	589	3	lin	lin	PROPN
gs-3960	589	4	mt	mt	PROPN
gs-3960	589	5	,	,	PUNCT
gs-3960	589	6	beal	beal	NOUN
gs-3960	589	7	mf	mf	NOUN
gs-3960	589	8	.	.	PROPN
gs-3960	589	9	mitochondrial	mitochondrial	ADJ
gs-3960	589	10	dysfunction	dysfunction	NOUN
gs-3960	589	11	and	and	CCONJ
gs-3960	589	12	oxidative	oxidative	ADJ
gs-3960	589	13	stress	stress	NOUN
gs-3960	589	14	in	in	ADP
gs-3960	589	15	20	20	NUM
gs-3960	589	16	.	.	PUNCT
gs-3960	590	1	kerr	kerr	PROPN
gs-3960	590	2	js	js	PROPN
gs-3960	590	3	,	,	PUNCT
gs-3960	590	4	adriaanse	adriaanse	PROPN
gs-3960	590	5	ba	ba	PROPN
gs-3960	590	6	,	,	PUNCT
gs-3960	590	7	greig	greig	PROPN
gs-3960	590	8	nh	nh	PROPN
gs-3960	590	9	,	,	PUNCT
gs-3960	590	10	mattson	mattson	PROPN
gs-3960	590	11	mp	mp	PROPN
gs-3960	590	12	,	,	PUNCT
gs-3960	590	13	cader	cader	PROPN
gs-3960	590	14	mz	mz	PROPN
gs-3960	590	15	,	,	PUNCT
gs-3960	590	16	bohr	bohr	PROPN
gs-3960	590	17	va	va	PROPN
gs-3960	590	18	,	,	PUNCT
gs-3960	590	19	et	et	PROPN
gs-3960	590	20	al	al	PROPN
gs-3960	590	21	.	.	PROPN
gs-3960	590	22	mitophagy	mitophagy	PROPN
gs-3960	590	23	and	and	CCONJ
gs-3960	590	24	alzheimer	alzheimer	PROPN
gs-3960	590	25	's	's	PART
gs-3960	590	26	disease	disease	NOUN
gs-3960	590	27	:	:	PUNCT
gs-3960	590	28	cellular	cellular	ADJ
gs-3960	590	29	and	and	CCONJ
gs-3960	590	30	molecular	molecular	ADJ
gs-3960	590	31	mechanisms	mechanism	NOUN
gs-3960	590	32	.	.	PUNCT
gs-3960	591	1	trends	trend	NOUN
gs-3960	591	2	21	21	NUM
gs-3960	591	3	.	.	PUNCT
gs-3960	592	1	koentjoro	koentjoro	PROPN
gs-3960	592	2	b	b	PROPN
gs-3960	592	3	,	,	PUNCT
gs-3960	592	4	park	park	NOUN
gs-3960	592	5	js	js	PROPN
gs-3960	592	6	,	,	PUNCT
gs-3960	592	7	sue	sue	NOUN
gs-3960	592	8	cm	cm	PROPN
gs-3960	592	9	.	.	PUNCT
gs-3960	593	1	nix	nix	PROPN
gs-3960	593	2	restores	restore	VERB
gs-3960	593	3	mitophagy	mitophagy	NOUN
gs-3960	593	4	and	and	CCONJ
gs-3960	593	5	mitochondrial	mitochondrial	ADJ
gs-3960	593	6	2017;7:44373	2017;7:44373	NOUN
gs-3960	593	7	.	.	PUNCT
gs-3960	594	1	22	22	NUM
gs-3960	594	2	.	.	PUNCT
gs-3960	595	1	gong	gong	PROPN
gs-3960	595	2	b	b	PROPN
gs-3960	595	3	,	,	PUNCT
gs-3960	595	4	pan	pan	PROPN
gs-3960	595	5	y	y	PROPN
gs-3960	595	6	,	,	PUNCT
gs-3960	595	7	vempati	vempati	NOUN
gs-3960	595	8	p	p	NOUN
gs-3960	595	9	,	,	PUNCT
gs-3960	595	10	zhao	zhao	PROPN
gs-3960	595	11	w	w	PROPN
gs-3960	595	12	,	,	PUNCT
gs-3960	595	13	knable	knable	ADJ
gs-3960	595	14	l	l	NOUN
gs-3960	595	15	,	,	PUNCT
gs-3960	595	16	ho	ho	PROPN
gs-3960	595	17	l	l	PROPN
gs-3960	595	18	,	,	PUNCT
gs-3960	595	19	et	et	PROPN
gs-3960	595	20	al	al	PROPN
gs-3960	595	21	.	.	PROPN
gs-3960	595	22	nicotinamide	nicotinamide	NOUN
gs-3960	595	23	riboside	riboside	NOUN
gs-3960	595	24	restores	restore	VERB
gs-3960	595	25	cognition	cognition	NOUN
gs-3960	595	26	through	through	ADP
gs-3960	595	27	an	an	DET
gs-3960	595	28	upregulation	upregulation	NOUN
gs-3960	595	29	of	of	ADP
gs-3960	595	30	proliferator	proliferator	NOUN
gs-3960	595	31	-	-	PUNCT
gs-3960	595	32	activated	activate	VERB
gs-3960	595	33	receptor	receptor	NOUN
gs-3960	595	34	coactivator	coactivator	NOUN
gs-3960	595	35	1	1	NUM
gs-3960	595	36	regulated	regulate	VERB
gs-3960	595	37	-secretase	-secretase	NOUN
gs-3960	595	38	1	1	NUM
gs-3960	595	39	degradation	degradation	NOUN
gs-3960	595	40	and	and	CCONJ
gs-3960	595	41	mitochondrial	mitochondrial	ADJ
gs-3960	595	42	gene	gene	NOUN
gs-3960	595	43	expression	expression	NOUN
gs-3960	595	44	23	23	NUM
gs-3960	595	45	.	.	PUNCT
gs-3960	596	1	fang	fang	PROPN
gs-3960	596	2	ef	ef	PROPN
gs-3960	596	3	,	,	PUNCT
gs-3960	596	4	scheibye	scheibye	NOUN
gs-3960	596	5	-	-	PUNCT
gs-3960	596	6	knudsen	knudsen	PROPN
gs-3960	596	7	m	m	PROPN
gs-3960	596	8	,	,	PUNCT
gs-3960	596	9	brace	brace	PROPN
gs-3960	596	10	le	le	PROPN
gs-3960	596	11	,	,	PUNCT
gs-3960	596	12	kassahun	kassahun	PROPN
gs-3960	596	13	h	h	PROPN
gs-3960	596	14	,	,	PUNCT
gs-3960	596	15	sengupta	sengupta	PROPN
gs-3960	596	16	t	t	PROPN
gs-3960	596	17	,	,	PUNCT
gs-3960	596	18	nilsen	nilsen	PROPN
gs-3960	596	19	h	h	PROPN
gs-3960	596	20	,	,	PUNCT
gs-3960	596	21	et	et	PROPN
gs-3960	596	22	al	al	PROPN
gs-3960	596	23	.	.	PROPN
gs-3960	596	24	defective	defective	ADJ
gs-3960	596	25	mitophagy	mitophagy	NOUN
gs-3960	596	26	in	in	ADP
gs-3960	596	27	xpa	xpa	PROPN
gs-3960	596	28	via	via	ADP
gs-3960	596	29	parp-1	parp-1	PROPN
gs-3960	596	30	hyperactivation	hyperactivation	NOUN
gs-3960	596	31	and	and	CCONJ
gs-3960	596	32	nad	nad	ADJ
gs-3960	596	33	/sirt1	/sirt1	NOUN
gs-3960	597	1	24	24	NUM
gs-3960	597	2	.	.	PUNCT
gs-3960	598	1	25	25	NUM
gs-3960	598	2	.	.	X
gs-3960	598	3	de	de	PROPN
gs-3960	598	4	castro	castro	PROPN
gs-3960	598	5	ip	ip	PROPN
gs-3960	598	6	,	,	PUNCT
gs-3960	598	7	martins	martin	NOUN
gs-3960	598	8	lm	lm	PROPN
gs-3960	598	9	,	,	PUNCT
gs-3960	598	10	loh	loh	PROPN
gs-3960	598	11	shy	shy	ADJ
gs-3960	598	12	.	.	PUNCT
gs-3960	599	1	mitochondrial	mitochondrial	ADJ
gs-3960	599	2	quality	quality	NOUN
gs-3960	599	3	control	control	NOUN
gs-3960	599	4	and	and	CCONJ
gs-3960	599	5	26	26	NUM
gs-3960	599	6	.	.	PUNCT
gs-3960	600	1	:	:	PUNCT
gs-3960	600	2	an	an	DET
gs-3960	600	3	old	old	ADJ
gs-3960	600	4	metabolite	metabolite	NOUN
gs-3960	600	5	controlling	control	VERB
gs-3960	600	6	new	new	ADJ
gs-3960	600	7	metabolic	metabolic	NOUN
gs-3960	600	8	signaling	signal	VERB
gs-3960	600	9	pathways	pathway	NOUN
gs-3960	600	10	.	.	PUNCT
gs-3960	601	1	endocr	endocr	PROPN
gs-3960	601	2	rev	rev	PROPN
gs-3960	601	3	.	.	PROPN
gs-3960	601	4	27	27	NUM
gs-3960	601	5	.	.	PUNCT
gs-3960	602	1	srivastava	srivastava	PROPN
gs-3960	602	2	s.	s.	PROPN
gs-3960	602	3	emerging	emerge	VERB
gs-3960	602	4	therapeutic	therapeutic	ADJ
gs-3960	602	5	roles	role	NOUN
gs-3960	602	6	for	for	ADP
gs-3960	602	7	nad	nad	ADJ
gs-3960	602	8	metabolism	metabolism	NOUN
gs-3960	602	9	in	in	ADP
gs-3960	602	10	mitochondrial	mitochondrial	ADJ
gs-3960	602	11	and	and	CCONJ
gs-3960	602	12	age	age	NOUN
gs-3960	602	13	-	-	PUNCT
gs-3960	602	14	related	relate	VERB
gs-3960	602	15	disorders	disorder	NOUN
gs-3960	602	16	.	.	PUNCT
gs-3960	603	1	clin	clin	PROPN
gs-3960	603	2	transl	transl	PROPN
gs-3960	603	3	med	med	PROPN
gs-3960	603	4	.	.	PUNCT
gs-3960	604	1	2016;5(1):25	2016;5(1):25	NUM
gs-3960	604	2	.	.	X
gs-3960	605	1	28	28	NUM
gs-3960	605	2	.	.	PUNCT
gs-3960	606	1	vos	vos	PROPN
gs-3960	606	2	m	m	PROPN
gs-3960	606	3	,	,	PUNCT
gs-3960	606	4	lauwers	lauwer	NOUN
gs-3960	606	5	e	e	PROPN
gs-3960	606	6	,	,	PUNCT
gs-3960	606	7	verstreken	verstreken	VERB
gs-3960	606	8	p.	p.	NOUN
gs-3960	606	9	synaptic	synaptic	ADJ
gs-3960	606	10	mitochondria	mitochondria	NOUN
gs-3960	606	11	in	in	ADP
gs-3960	606	12	synaptic	synaptic	ADJ
gs-3960	606	13	transmission	transmission	NOUN
gs-3960	606	14	and	and	CCONJ
gs-3960	606	15	organization	organization	NOUN
gs-3960	606	16	of	of	ADP
gs-3960	606	17	vesicle	vesicle	NOUN
gs-3960	606	18	pools	pool	NOUN
gs-3960	606	19	in	in	ADP
gs-3960	606	20	health	health	NOUN
gs-3960	606	21	and	and	CCONJ
gs-3960	606	22	disease	disease	NOUN
gs-3960	606	23	.	.	PUNCT
gs-3960	607	1	front	front	ADJ
gs-3960	607	2	synaptic	synaptic	ADJ
gs-3960	607	3	neurosci	neurosci	NOUN
gs-3960	607	4	.	.	PUNCT
gs-3960	608	1	2010;2:139	2010;2:139	ADJ
gs-3960	608	2	.	.	PUNCT
gs-3960	609	1	29	29	NUM
gs-3960	609	2	.	.	PUNCT
gs-3960	610	1	mor	mor	PROPN
gs-3960	611	1	de	de	PROPN
gs-3960	611	2	,	,	PUNCT
gs-3960	611	3	sohrabi	sohrabi	PROPN
gs-3960	611	4	s	s	PROPN
gs-3960	611	5	,	,	PUNCT
gs-3960	611	6	kaletsky	kaletsky	ADJ
gs-3960	611	7	r	r	NOUN
gs-3960	611	8	,	,	PUNCT
gs-3960	611	9	keyes	keyes	PROPN
gs-3960	611	10	w	w	PROPN
gs-3960	611	11	,	,	PUNCT
gs-3960	611	12	tartici	tartici	PROPN
gs-3960	611	13	a	a	PRON
gs-3960	611	14	,	,	PUNCT
gs-3960	611	15	kalia	kalia	PROPN
gs-3960	611	16	v	v	PROPN
gs-3960	611	17	,	,	PUNCT
gs-3960	611	18	et	et	PROPN
gs-3960	611	19	al	al	PROPN
gs-3960	611	20	.	.	PROPN
gs-3960	612	1	metformin	metformin	PROPN
gs-3960	612	2	georgian	georgian	PROPN
gs-3960	612	3	scientists/	scientists/	NUM
gs-3960	612	4	.	.	PUNCT
gs-3960	613	1	7	7	NUM
gs-3960	613	2	n	n	PRON
gs-3960	613	3	3	3	NUM
gs-3960	613	4	,	,	PUNCT
gs-3960	613	5	2025	2025	NUM
gs-3960	613	6	436	436	NUM
gs-3960	613	7	30	30	NUM
gs-3960	613	8	.	.	PUNCT
gs-3960	614	1	giorgi	giorgi	NOUN
gs-3960	614	2	c	c	PROPN
gs-3960	614	3	,	,	PUNCT
gs-3960	614	4	marchi	marchi	PROPN
gs-3960	614	5	s	s	PROPN
gs-3960	614	6	,	,	PUNCT
gs-3960	614	7	pinton	pinton	PROPN
gs-3960	614	8	p.	p.	NOUN
gs-3960	614	9	the	the	DET
gs-3960	614	10	machineries	machinery	NOUN
gs-3960	614	11	,	,	PUNCT
gs-3960	614	12	regulation	regulation	NOUN
gs-3960	614	13	and	and	CCONJ
gs-3960	614	14	cellular	cellular	ADJ
gs-3960	614	15	31	31	NUM
gs-3960	614	16	.	.	PUNCT
gs-3960	615	1	aphkhazava	aphkhazava	PROPN
gs-3960	615	2	,	,	PUNCT
gs-3960	615	3	d.	d.	PROPN
gs-3960	615	4	,	,	PUNCT
gs-3960	615	5	sulashvili	sulashvili	NOUN
gs-3960	615	6	,	,	PUNCT
gs-3960	615	7	n.	n.	NOUN
gs-3960	615	8	,	,	PUNCT
gs-3960	615	9	tupinashvili	tupinashvili	NOUN
gs-3960	615	10	,	,	PUNCT
gs-3960	615	11	t.	t.	PROPN
gs-3960	615	12	,	,	PUNCT
gs-3960	615	13	&	&	CCONJ
gs-3960	615	14	nozadze	nozadze	NOUN
gs-3960	615	15	,	,	PUNCT
gs-3960	615	16	m.	m.	NOUN
gs-3960	615	17	(	(	PUNCT
gs-3960	615	18	2024	2024	NUM
gs-3960	615	19	)	)	PUNCT
gs-3960	615	20	.	.	PUNCT
gs-3960	616	1	dynamic	dynamic	ADJ
gs-3960	616	2	cellular	cellular	ADJ
gs-3960	616	3	equilibrium	equilibrium	NOUN
gs-3960	616	4	theory	theory	NOUN
gs-3960	616	5	of	of	ADP
gs-3960	616	6	aging	aging	NOUN
gs-3960	616	7	:	:	PUNCT
gs-3960	616	8	integrating	integrate	VERB
gs-3960	616	9	maintenance	maintenance	NOUN
gs-3960	616	10	and	and	CCONJ
gs-3960	616	11	https://doi.org/10.52340/spectri.2023.08.02.03	https://doi.org/10.52340/spectri.2023.08.02.03	ADJ
gs-3960	616	12	32	32	NUM
gs-3960	616	13	.	.	PUNCT
gs-3960	617	1	sulashvili	sulashvili	PROPN
gs-3960	617	2	n	n	PROPN
gs-3960	617	3	,	,	PUNCT
gs-3960	617	4	jadhav	jadhav	PROPN
gs-3960	617	5	rd	rd	PROPN
gs-3960	617	6	,	,	PUNCT
gs-3960	617	7	beglaryan	beglaryan	PROPN
gs-3960	617	8	m	m	PROPN
gs-3960	617	9	,	,	PUNCT
gs-3960	617	10	gabunia	gabunia	NOUN
gs-3960	617	11	l	l	NOUN
gs-3960	617	12	,	,	PUNCT
gs-3960	617	13	gorgaslidze	gorgaslidze	ADJ
gs-3960	617	14	n	n	CCONJ
gs-3960	617	15	,	,	PUNCT
gs-3960	617	16	alavidze	alavidze	PROPN
gs-3960	617	17	n	n	CCONJ
gs-3960	617	18	,	,	PUNCT
gs-3960	617	19	et	et	PROPN
gs-3960	617	20	al	al	PROPN
gs-3960	617	21	.	.	PUNCT
gs-3960	618	1	the	the	DET
gs-3960	618	2	scientific	scientific	ADJ
gs-3960	618	3	discussion	discussion	NOUN
gs-3960	618	4	of	of	ADP
gs-3960	618	5	key	key	ADJ
gs-3960	618	6	issue	issue	NOUN
gs-3960	618	7	aspects	aspect	NOUN
gs-3960	618	8	of	of	ADP
gs-3960	618	9	immunopathogenesis	immunopathogenesis	NOUN
gs-3960	618	10	and	and	CCONJ
gs-3960	618	11	pharmacological	pharmacological	NOUN
gs-3960	618	12	properties	property	NOUN
gs-3960	618	13	and	and	CCONJ
gs-3960	618	14	profiles	profile	NOUN
gs-3960	618	15	in	in	ADP
gs-3960	618	16	relation	relation	NOUN
gs-3960	618	17	to	to	ADP
gs-3960	618	18	adverse	adverse	ADJ
gs-3960	618	19	drug	drug	NOUN
gs-3960	618	20	reactions	reaction	NOUN
gs-3960	618	21	challenges	challenge	NOUN
gs-3960	618	22	,	,	PUNCT
gs-3960	618	23	focus	focus	VERB
gs-3960	618	24	on	on	ADP
gs-3960	618	25	multidimensional	multidimensional	ADJ
gs-3960	618	26	drug	drug	NOUN
gs-3960	618	27	-	-	PUNCT
gs-3960	618	28	induced	induce	VERB
gs-3960	618	29	eosinophilia	eosinophilia	NOUN
gs-3960	618	30	and	and	CCONJ
gs-3960	618	31	systemic	systemic	ADJ
gs-3960	618	32	syndrome	syndrome	NOUN
gs-3960	618	33	.	.	PUNCT
gs-3960	619	1	gs	gs	X
gs-3960	620	1	[	[	X
gs-3960	620	2	internet	internet	NOUN
gs-3960	620	3	]	]	X
gs-3960	620	4	.	.	PUNCT
gs-3960	621	1	2025	2025	NUM
gs-3960	621	2	jul	jul	NOUN
gs-3960	621	3	.	.	PROPN
gs-3960	621	4	11	11	NUM
gs-3960	622	1	[	[	X
gs-3960	622	2	cited	cite	VERB
gs-3960	622	3	2025	2025	NUM
gs-3960	622	4	jul	jul	PROPN
gs-3960	622	5	.	.	PUNCT
gs-3960	623	1	12];7(3):141	12];7(3):141	NUM
gs-3960	623	2	-	-	SYM
gs-3960	623	3	79	79	NUM
gs-3960	623	4	.	.	PUNCT
gs-3960	624	1	available	available	ADJ
gs-3960	624	2	from	from	ADP
gs-3960	624	3	:	:	PUNCT
gs-3960	624	4	https://journals.4science.ge/index.php/gs/article/view/3919	https://journals.4science.ge/index.php/gs/article/view/3919	NOUN
gs-3960	624	5	.	.	X
gs-3960	624	6	33	33	NUM
gs-3960	624	7	.	.	PUNCT
gs-3960	625	1	sulashvili	sulashvili	PROPN
gs-3960	625	2	n	n	PROPN
gs-3960	625	3	,	,	PUNCT
gs-3960	625	4	fernando	fernando	PROPN
gs-3960	625	5	s	s	PROPN
gs-3960	625	6	,	,	PUNCT
gs-3960	625	7	el	el	PROPN
gs-3960	625	8	-	-	PUNCT
gs-3960	625	9	hakeem	hakeem	PROPN
gs-3960	625	10	a	a	PRON
gs-3960	625	11	,	,	PUNCT
gs-3960	625	12	gabunia	gabunia	NOUN
gs-3960	625	13	l	l	NOUN
gs-3960	625	14	,	,	PUNCT
gs-3960	625	15	gorgaslidze	gorgaslidze	ADJ
gs-3960	625	16	n	n	CCONJ
gs-3960	625	17	,	,	PUNCT
gs-3960	625	18	beglaryan	beglaryan	PROPN
gs-3960	625	19	m	m	PROPN
gs-3960	625	20	,	,	PUNCT
gs-3960	625	21	et	et	PROPN
gs-3960	625	22	al	al	PROPN
gs-3960	625	23	.	.	PROPN
gs-3960	625	24	closed	close	VERB
gs-3960	625	25	-	-	PUNCT
gs-3960	625	26	loop	loop	NOUN
gs-3960	625	27	cardiopulmonary	cardiopulmonary	ADJ
gs-3960	625	28	bypass	bypass	NOUN
gs-3960	625	29	systems	system	NOUN
gs-3960	625	30	with	with	ADP
gs-3960	625	31	realtime	realtime	NOUN
gs-3960	625	32	monitoring	monitoring	NOUN
gs-3960	625	33	and	and	CCONJ
gs-3960	625	34	pharmacotherapy	pharmacotherapy	NOUN
gs-3960	625	35	strategies	strategy	NOUN
gs-3960	625	36	:	:	PUNCT
gs-3960	625	37	innovations	innovation	NOUN
gs-3960	625	38	,	,	PUNCT
gs-3960	625	39	outcomes	outcome	NOUN
gs-3960	625	40	,	,	PUNCT
gs-3960	625	41	clinical	clinical	ADJ
gs-3960	625	42	impact	impact	NOUN
gs-3960	625	43	and	and	CCONJ
gs-3960	625	44	future	future	ADJ
gs-3960	625	45	directions	direction	NOUN
gs-3960	625	46	in	in	ADP
gs-3960	625	47	general	general	ADJ
gs-3960	625	48	.	.	PUNCT
gs-3960	626	1	gs	gs	PROPN
gs-3960	627	1	[	[	X
gs-3960	627	2	internet	internet	NOUN
gs-3960	627	3	]	]	PUNCT
gs-3960	627	4	.	.	PUNCT
gs-3960	628	1	2025	2025	NUM
gs-3960	628	2	may	may	AUX
gs-3960	628	3	30	30	NUM
gs-3960	628	4	[	[	NOUN
gs-3960	628	5	cited	cite	VERB
gs-3960	628	6	2025	2025	NUM
gs-3960	628	7	jul	jul	PROPN
gs-3960	628	8	.	.	PROPN
gs-3960	629	1	12];7(2):381	12];7(2):381	NUM
gs-3960	629	2	-	-	SYM
gs-3960	629	3	419	419	NUM
gs-3960	629	4	.	.	PUNCT
gs-3960	630	1	available	available	ADJ
gs-3960	630	2	from	from	ADP
gs-3960	630	3	:	:	PUNCT
gs-3960	630	4	https://journals.4science.ge/index.php/gs/article/view/3799	https://journals.4science.ge/index.php/gs/article/view/3799	PROPN
gs-3960	630	5	.	.	PUNCT
gs-3960	631	1	34	34	NUM
gs-3960	631	2	.	.	PUNCT
gs-3960	632	1	nodar	nodar	PROPN
gs-3960	632	2	sulashvili	sulashvili	NOUN
gs-3960	632	3	,	,	PUNCT
gs-3960	632	4	rupali	rupali	VERB
gs-3960	632	5	digambar	digambar	PROPN
gs-3960	632	6	jadhav	jadhav	PROPN
gs-3960	632	7	,	,	PUNCT
gs-3960	632	8	margarita	margarita	PROPN
gs-3960	632	9	beglaryan	beglaryan	PROPN
gs-3960	632	10	,	,	PUNCT
gs-3960	632	11	nana	nana	PROPN
gs-3960	632	12	gorgaslidze	gorgaslidze	PROPN
gs-3960	632	13	,	,	PUNCT
gs-3960	632	14	luiza	luiza	PROPN
gs-3960	632	15	gabunia	gabunia	PROPN
gs-3960	632	16	,	,	PUNCT
gs-3960	632	17	nato	nato	PROPN
gs-3960	632	18	alavidze	alavidze	PROPN
gs-3960	632	19	,	,	PUNCT
gs-3960	632	20	natia	natia	PROPN
gs-3960	632	21	kvizhinadze	kvizhinadze	PROPN
gs-3960	632	22	,	,	PUNCT
gs-3960	632	23	marika	marika	PROPN
gs-3960	632	24	sulashvili	sulashvili	PROPN
gs-3960	632	25	,	,	PUNCT
gs-3960	632	26	lela	lela	PROPN
gs-3960	632	27	pharmacogenetic	pharmacogenetic	ADJ
gs-3960	632	28	and	and	CCONJ
gs-3960	632	29	clinical	clinical	ADJ
gs-3960	632	30	perspectives	perspective	NOUN
gs-3960	632	31	on	on	ADP
gs-3960	632	32	medicationassociated	medicationassociated	ADJ
gs-3960	632	33	eosinophilia	eosinophilia	PROPN
gs-3960	632	34	and	and	CCONJ
gs-3960	632	35	systemic	systemic	ADJ
gs-3960	632	36	symptoms	symptom	NOUN
gs-3960	632	37	(	(	PUNCT
gs-3960	632	38	dress	dress	NOUN
gs-3960	632	39	):	):	PUNCT
gs-3960	632	40	a	a	DET
gs-3960	632	41	comprehensive	comprehensive	ADJ
gs-3960	632	42	evaluation	evaluation	NOUN
gs-3960	632	43	of	of	ADP
gs-3960	632	44	implicated	implicated	ADJ
gs-3960	632	45	agents	agent	NOUN
gs-3960	632	46	,	,	PUNCT
gs-3960	632	47	risk	risk	NOUN
gs-3960	632	48	factors	factor	NOUN
gs-3960	632	49	,	,	PUNCT
gs-3960	632	50	scientists	scientist	NOUN
gs-3960	632	51	7	7	NUM
gs-3960	632	52	(	(	PUNCT
gs-3960	632	53	3):180	3):180	NUM
gs-3960	632	54	-	-	SYM
gs-3960	632	55	216	216	NUM
gs-3960	632	56	.	.	PUNCT
gs-3960	633	1	https://doi.org/10.52340/gs.2025.07.03.14	https://doi.org/10.52340/gs.2025.07.03.14	PROPN
gs-3960	633	2	.	.	NOUN
gs-3960	633	3	35	35	NUM
gs-3960	633	4	.	.	PUNCT
gs-3960	634	1	sulashvili	sulashvili	NOUN
gs-3960	634	2	,	,	PUNCT
gs-3960	634	3	nodar	nodar	ADV
gs-3960	634	4	,	,	PUNCT
gs-3960	634	5	lali	lali	PROPN
gs-3960	634	6	patsia	patsia	PROPN
gs-3960	634	7	,	,	PUNCT
gs-3960	634	8	awad	awad	PROPN
gs-3960	634	9	el	el	PROPN
gs-3960	634	10	-	-	PUNCT
gs-3960	634	11	hakeem	hakeem	PROPN
gs-3960	634	12	,	,	PUNCT
gs-3960	634	13	sk	sk	PROPN
gs-3960	634	14	ayaan	ayaan	PROPN
gs-3960	634	15	,	,	PUNCT
gs-3960	634	16	arian	arian	ADJ
gs-3960	634	17	hizomi	hizomi	NOUN
gs-3960	634	18	,	,	PUNCT
gs-3960	634	19	the	the	DET
gs-3960	634	20	role	role	NOUN
gs-3960	634	21	of	of	ADP
gs-3960	634	22	the	the	DET
gs-3960	634	23	microbiome	microbiome	NOUN
gs-3960	634	24	in	in	ADP
gs-3960	634	25	modulating	modulate	VERB
gs-3960	634	26	brain	brain	NOUN
gs-3960	634	27	function	function	NOUN
gs-3960	634	28	and	and	CCONJ
gs-3960	634	29	its	its	PRON
gs-3960	634	30	georgian	georgian	ADJ
gs-3960	634	31	scientists	scientist	NOUN
gs-3960	634	32	7	7	NUM
gs-3960	634	33	(	(	PUNCT
gs-3960	634	34	2):329	2):329	NUM
gs-3960	634	35	-	-	SYM
gs-3960	634	36	53	53	NUM
gs-3960	634	37	.	.	PUNCT
gs-3960	635	1	https://doi.org/10.52340/gs.2025.07.02.32	https://doi.org/10.52340/gs.2025.07.02.32	PROPN
gs-3960	635	2	.	.	PROPN
gs-3960	635	3	36	36	NUM
gs-3960	635	4	.	.	PUNCT
gs-3960	636	1	sulashvili	sulashvili	NOUN
gs-3960	636	2	,	,	PUNCT
gs-3960	636	3	n.	n.	NOUN
gs-3960	636	4	,	,	PUNCT
gs-3960	636	5	gorgaslidze	gorgaslidze	PROPN
gs-3960	636	6	,	,	PUNCT
gs-3960	636	7	n.	n.	NOUN
gs-3960	636	8	,	,	PUNCT
gs-3960	636	9	gabunia	gabunia	NOUN
gs-3960	636	10	,	,	PUNCT
gs-3960	636	11	l.	l.	PROPN
gs-3960	636	12	,	,	PUNCT
gs-3960	636	13	giorgobiani	giorgobiani	PROPN
gs-3960	636	14	,	,	PUNCT
gs-3960	636	15	m.	m.	NOUN
gs-3960	636	16	,	,	PUNCT
gs-3960	636	17	&	&	CCONJ
gs-3960	636	18	ratiani	ratiani	PROPN
gs-3960	636	19	,	,	PUNCT
gs-3960	636	20	l.	l.	PROPN
gs-3960	636	21	(	(	PUNCT
gs-3960	636	22	2023	2023	NUM
gs-3960	636	23	)	)	PUNCT
gs-3960	636	24	.	.	PUNCT
gs-3960	637	1	manifestation	manifestation	NOUN
gs-3960	637	2	of	of	ADP
gs-3960	637	3	the	the	DET
gs-3960	637	4	particularities	particularity	NOUN
gs-3960	637	5	of	of	ADP
gs-3960	637	6	the	the	DET
gs-3960	637	7	usage	usage	NOUN
gs-3960	637	8	features	feature	NOUN
gs-3960	637	9	of	of	ADP
gs-3960	637	10	monoclonal	monoclonal	NOUN
gs-3960	637	11	antibodies	antibody	NOUN
gs-3960	637	12	in	in	ADP
gs-3960	637	13	various	various	ADJ
gs-3960	637	14	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-3960	637	15	applications	application	NOUN
gs-3960	637	16	.	.	PUNCT
gs-3960	638	1	experimental	experimental	ADJ
gs-3960	638	2	and	and	CCONJ
gs-3960	638	3	clinical	clinical	ADJ
gs-3960	638	4	medicine	medicine	NOUN
gs-3960	638	5	37	37	NUM
gs-3960	638	6	.	.	PUNCT
gs-3960	639	1	sulashvili	sulashvili	NOUN
gs-3960	639	2	,	,	PUNCT
gs-3960	639	3	n.	n.	NOUN
gs-3960	639	4	,	,	PUNCT
gs-3960	639	5	davitashvili	davitashvili	ADJ
gs-3960	639	6	,	,	PUNCT
gs-3960	639	7	m.	m.	NOUN
gs-3960	639	8	,	,	PUNCT
gs-3960	639	9	gorgaslidze	gorgaslidze	PROPN
gs-3960	639	10	,	,	PUNCT
gs-3960	639	11	n.	n.	NOUN
gs-3960	639	12	,	,	PUNCT
gs-3960	639	13	gabunia	gabunia	NOUN
gs-3960	639	14	,	,	PUNCT
gs-3960	639	15	l.	l.	PROPN
gs-3960	639	16	,	,	PUNCT
gs-3960	639	17	beglaryan	beglaryan	ADJ
gs-3960	639	18	,	,	PUNCT
gs-3960	639	19	m.	m.	NOUN
gs-3960	639	20	,	,	PUNCT
gs-3960	639	21	georgian	georgian	NOUN
gs-3960	639	22	scientists/	scientists/	NUM
gs-3960	639	23	.	.	PUNCT
gs-3960	640	1	7	7	NUM
gs-3960	640	2	n	n	PRON
gs-3960	640	3	3	3	NUM
gs-3960	640	4	,	,	PUNCT
gs-3960	640	5	2025	2025	NUM
gs-3960	640	6	437	437	NUM
gs-3960	640	7	issues	issue	NOUN
gs-3960	640	8	of	of	ADP
gs-3960	640	9	features	feature	NOUN
gs-3960	640	10	and	and	CCONJ
gs-3960	640	11	challenges	challenge	NOUN
gs-3960	640	12	of	of	ADP
gs-3960	640	13	using	use	VERB
gs-3960	640	14	of	of	ADP
gs-3960	640	15	car	car	NOUN
gs-3960	640	16	-	-	PUNCT
gs-3960	640	17	t	t	NOUN
gs-3960	640	18	cells	cell	NOUN
gs-3960	640	19	in	in	ADP
gs-3960	640	20	https://doi.org/10.52340/gs.2024.06.04.24	https://doi.org/10.52340/gs.2024.06.04.24	PROPN
gs-3960	640	21	38	38	NUM
gs-3960	640	22	.	.	PUNCT
gs-3960	641	1	sulashvili	sulashvili	NOUN
gs-3960	641	2	,	,	PUNCT
gs-3960	641	3	n.	n.	NOUN
gs-3960	641	4	,	,	PUNCT
gs-3960	641	5	gorgaslidze	gorgaslidze	PROPN
gs-3960	641	6	,	,	PUNCT
gs-3960	641	7	n.	n.	NOUN
gs-3960	641	8	,	,	PUNCT
gs-3960	641	9	gabunia	gabunia	NOUN
gs-3960	641	10	,	,	PUNCT
gs-3960	641	11	l.	l.	PROPN
gs-3960	641	12	,	,	PUNCT
gs-3960	641	13	giorgobiani	giorgobiani	PROPN
gs-3960	641	14	,	,	PUNCT
gs-3960	641	15	m.	m.	NOUN
gs-3960	641	16	,	,	PUNCT
gs-3960	641	17	&	&	CCONJ
gs-3960	641	18	ratiani	ratiani	PROPN
gs-3960	641	19	,	,	PUNCT
gs-3960	641	20	l.	l.	PROPN
gs-3960	641	21	(	(	PUNCT
gs-3960	641	22	2023	2023	NUM
gs-3960	641	23	)	)	PUNCT
gs-3960	641	24	.	.	PUNCT
gs-3960	642	1	manifestation	manifestation	NOUN
gs-3960	642	2	of	of	ADP
gs-3960	642	3	the	the	DET
gs-3960	642	4	particularities	particularity	NOUN
gs-3960	642	5	of	of	ADP
gs-3960	642	6	the	the	DET
gs-3960	642	7	usage	usage	NOUN
gs-3960	642	8	features	feature	NOUN
gs-3960	642	9	of	of	ADP
gs-3960	642	10	monoclonal	monoclonal	NOUN
gs-3960	642	11	antibodies	antibody	NOUN
gs-3960	642	12	in	in	ADP
gs-3960	642	13	various	various	ADJ
gs-3960	642	14	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-3960	642	15	applications	application	NOUN
gs-3960	642	16	.	.	PUNCT
gs-3960	643	1	experimental	experimental	ADJ
gs-3960	643	2	and	and	CCONJ
gs-3960	643	3	clinical	clinical	ADJ
gs-3960	643	4	medicine	medicine	NOUN
gs-3960	643	5	39	39	NUM
gs-3960	643	6	.	.	PUNCT
gs-3960	644	1	sulashvili	sulashvili	NOUN
gs-3960	644	2	,	,	PUNCT
gs-3960	644	3	n.	n.	NOUN
gs-3960	644	4	,	,	PUNCT
gs-3960	644	5	gorgaslidze	gorgaslidze	PROPN
gs-3960	644	6	,	,	PUNCT
gs-3960	644	7	n.	n.	NOUN
gs-3960	644	8	,	,	PUNCT
gs-3960	644	9	gabunia	gabunia	NOUN
gs-3960	644	10	,	,	PUNCT
gs-3960	644	11	l.	l.	PROPN
gs-3960	644	12	,	,	PUNCT
gs-3960	644	13	ratiani	ratiani	PROPN
gs-3960	644	14	,	,	PUNCT
gs-3960	644	15	l.	l.	PROPN
gs-3960	644	16	,	,	PUNCT
gs-3960	644	17	khetsuriani	khetsuriani	PROPN
gs-3960	644	18	,	,	PUNCT
gs-3960	644	19	s.	s.	PROPN
gs-3960	644	20	,	,	PUNCT
gs-3960	644	21	kravchenko	kravchenko	PROPN
gs-3960	644	22	,	,	PUNCT
gs-3960	644	23	v.	v.	NOUN
gs-3960	644	24	,	,	PUNCT
gs-3960	644	25	sulashvili	sulashvili	NOUN
gs-3960	644	26	,	,	PUNCT
gs-3960	644	27	m.	m.	NOUN
gs-3960	644	28	(	(	PUNCT
gs-3960	644	29	2024	2024	NUM
gs-3960	644	30	)	)	PUNCT
gs-3960	644	31	.	.	PUNCT
gs-3960	645	1	manifestation	manifestation	NOUN
gs-3960	645	2	of	of	ADP
gs-3960	645	3	the	the	DET
gs-3960	645	4	particularities	particularity	NOUN
gs-3960	645	5	of	of	ADP
gs-3960	645	6	some	some	DET
gs-3960	645	7	key	key	ADJ
gs-3960	645	8	issue	issue	NOUN
gs-3960	645	9	aspects	aspect	NOUN
gs-3960	645	10	of	of	ADP
gs-3960	645	11	new	new	ADJ
gs-3960	645	12	immunotherapy	immunotherapy	NOUN
gs-3960	645	13	challenges	challenge	NOUN
gs-3960	645	14	and	and	CCONJ
gs-3960	645	15	perspectives	perspective	NOUN
gs-3960	645	16	by	by	ADP
gs-3960	645	17	car	car	NOUN
gs-3960	645	18	-	-	PUNCT
gs-3960	645	19	t	t	NOUN
gs-3960	645	20	cell	cell	NOUN
gs-3960	645	21	https://doi.org/10.52340/jecm.2024.04.32	https://doi.org/10.52340/jecm.2024.04.32	NUM
gs-3960	645	22	.	.	NOUN
gs-3960	645	23	40	40	NUM
gs-3960	645	24	.	.	PUNCT
gs-3960	646	1	sulashvili	sulashvili	NOUN
gs-3960	646	2	,	,	PUNCT
gs-3960	646	3	n.	n.	NOUN
gs-3960	646	4	.	.	PUNCT
gs-3960	647	1	.	.	PUNCT
gs-3960	647	2	,	,	PUNCT
gs-3960	648	1	gorgaslidze	gorgaslidze	INTJ
gs-3960	648	2	,	,	PUNCT
gs-3960	648	3	n.	n.	PROPN
gs-3960	648	4	.	.	PUNCT
gs-3960	649	1	,	,	PUNCT
gs-3960	649	2	beglaryan	beglaryan	ADJ
gs-3960	649	3	,	,	PUNCT
gs-3960	649	4	m.	m.	NOUN
gs-3960	649	5	.	.	PUNCT
gs-3960	650	1	,	,	PUNCT
gs-3960	650	2	gabunia	gabunia	VERB
gs-3960	650	3	the	the	DET
gs-3960	650	4	scientific	scientific	ADJ
gs-3960	650	5	talks	talk	NOUN
gs-3960	650	6	of	of	ADP
gs-3960	650	7	essential	essential	ADJ
gs-3960	650	8	issue	issue	NOUN
gs-3960	650	9	,	,	PUNCT
gs-3960	650	10	invocation	invocation	NOUN
gs-3960	650	11	,	,	PUNCT
gs-3960	650	12	perspectives	perspective	NOUN
gs-3960	650	13	,	,	PUNCT
gs-3960	650	14	inclinations	inclination	NOUN
gs-3960	650	15	and	and	CCONJ
gs-3960	650	16	features	feature	NOUN
gs-3960	650	17	of	of	ADP
gs-3960	650	18	the	the	DET
gs-3960	650	19	clinical	clinical	ADJ
gs-3960	650	20	pharmacists	pharmacist	NOUN
gs-3960	650	21	globally	globally	ADV
gs-3960	650	22	.	.	PUNCT
gs-3960	651	1	experimental	experimental	ADJ
gs-3960	651	2	and	and	CCONJ
gs-3960	651	3	clinical	clinical	ADJ
gs-3960	651	4	medicine	medicine	NOUN
gs-3960	651	5	georgia	georgia	PROPN
gs-3960	651	6	,	,	PUNCT
gs-3960	651	7	(	(	PUNCT
gs-3960	651	8	7	7	NUM
gs-3960	651	9	)	)	PUNCT
gs-3960	651	10	.	.	PUNCT
gs-3960	652	1	41	41	NUM
gs-3960	652	2	.	.	PUNCT
gs-3960	653	1	sulashvili	sulashvili	PROPN
gs-3960	653	2	n	n	CCONJ
gs-3960	653	3	,	,	PUNCT
gs-3960	653	4	nimangre	nimangre	PROPN
gs-3960	653	5	rr	rr	PROPN
gs-3960	653	6	.	.	PUNCT
gs-3960	654	1	manifestation	manifestation	NOUN
gs-3960	654	2	of	of	ADP
gs-3960	654	3	some	some	DET
gs-3960	654	4	aspects	aspect	NOUN
gs-3960	654	5	of	of	ADP
gs-3960	654	6	cardiovascular	cardiovascular	ADJ
gs-3960	654	7	diseases	disease	NOUN
gs-3960	654	8	,	,	PUNCT
gs-3960	654	9	implications	implication	NOUN
gs-3960	654	10	,	,	PUNCT
gs-3960	654	11	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-3960	654	12	strategies	strategy	NOUN
gs-3960	654	13	,	,	PUNCT
gs-3960	654	14	effects	effect	NOUN
gs-3960	654	15	,	,	PUNCT
gs-3960	654	16	impacts	impact	NOUN
gs-3960	654	17	and	and	CCONJ
gs-3960	654	18	potential	potential	ADJ
gs-3960	654	19	hazards	hazard	NOUN
gs-3960	654	20	in	in	ADP
gs-3960	654	21	general	general	ADJ
gs-3960	654	22	.	.	PUNCT
gs-3960	655	1	jr	jr	PROPN
gs-3960	656	1	[	[	X
gs-3960	656	2	internet	internet	NOUN
gs-3960	656	3	]	]	PUNCT
gs-3960	656	4	.	.	PUNCT
gs-3960	657	1	2025	2025	NUM
gs-3960	657	2	feb	feb	X
gs-3960	657	3	.	.	PROPN
gs-3960	657	4	7	7	NUM
gs-3960	657	5	[	[	X
gs-3960	657	6	cited	cite	VERB
gs-3960	657	7	2025	2025	NUM
gs-3960	657	8	may	may	PROPN
gs-3960	657	9	22];3(1):1	22];3(1):1	NUM
gs-3960	657	10	-	-	SYM
gs-3960	657	11	27	27	NUM
gs-3960	657	12	.	.	PUNCT
gs-3960	658	1	available	available	ADJ
gs-3960	658	2	from	from	ADP
gs-3960	658	3	:	:	PUNCT
gs-3960	658	4	https://journals.4science.ge/index.php/jr/article/view/3393	https://journals.4science.ge/index.php/jr/article/view/3393	PROPN
gs-3960	658	5	.	.	PUNCT
gs-3960	659	1	42	42	NUM
gs-3960	659	2	.	.	PUNCT
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gs-3960	660	2	n	n	CCONJ
gs-3960	660	3	,	,	PUNCT
gs-3960	660	4	yaduvanshi	yaduvanshi	NOUN
gs-3960	660	5	u	u	NOUN
gs-3960	660	6	,	,	PUNCT
gs-3960	660	7	yadav	yadav	PROPN
gs-3960	660	8	m	m	PROPN
gs-3960	660	9	,	,	PUNCT
gs-3960	660	10	gabunia	gabunia	NOUN
gs-3960	660	11	l	l	NOUN
gs-3960	660	12	,	,	PUNCT
gs-3960	660	13	ghambashidze	ghambashidze	PROPN
gs-3960	660	14	k	k	PROPN
gs-3960	660	15	,	,	PUNCT
gs-3960	660	16	gorgaslidze	gorgaslidze	ADJ
gs-3960	660	17	n	n	CCONJ
gs-3960	660	18	,	,	PUNCT
gs-3960	660	19	et	et	PROPN
gs-3960	660	20	al	al	PROPN
gs-3960	660	21	.	.	PUNCT
gs-3960	661	1	the	the	DET
gs-3960	661	2	scientific	scientific	ADJ
gs-3960	661	3	discourse	discourse	NOUN
gs-3960	661	4	of	of	ADP
gs-3960	661	5	features	feature	NOUN
gs-3960	661	6	of	of	ADP
gs-3960	661	7	clinical	clinical	ADJ
gs-3960	661	8	use	use	NOUN
gs-3960	661	9	and	and	CCONJ
gs-3960	661	10	pharmacology	pharmacology	NOUN
gs-3960	661	11	of	of	ADP
gs-3960	661	12	vasoconstrictors	vasoconstrictor	NOUN
gs-3960	661	13	and	and	CCONJ
gs-3960	661	14	their	their	PRON
gs-3960	661	15	impact	impact	NOUN
gs-3960	661	16	on	on	ADP
gs-3960	661	17	cardiac	cardiac	ADJ
gs-3960	661	18	function	function	NOUN
gs-3960	661	19	.	.	PUNCT
gs-3960	662	1	jr	jr	PROPN
gs-3960	663	1	[	[	X
gs-3960	663	2	internet	internet	NOUN
gs-3960	663	3	]	]	PUNCT
gs-3960	663	4	.	.	PUNCT
gs-3960	664	1	2025	2025	NUM
gs-3960	664	2	feb	feb	X
gs-3960	664	3	.	.	PROPN
gs-3960	664	4	21	21	NUM
gs-3960	664	5	[	[	X
gs-3960	664	6	cited	cite	VERB
gs-3960	664	7	2025	2025	NUM
gs-3960	664	8	may	may	PROPN
gs-3960	664	9	22];3(1):28	22];3(1):28	NUM
gs-3960	664	10	-	-	SYM
gs-3960	664	11	6	6	NUM
gs-3960	664	12	.	.	PUNCT
gs-3960	665	1	available	available	ADJ
gs-3960	665	2	from	from	ADP
gs-3960	665	3	:	:	PUNCT
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gs-3960	665	5	.	.	PUNCT
gs-3960	666	1	43	43	NUM
gs-3960	666	2	.	.	PUNCT
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gs-3960	667	2	sulashvili	sulashvili	NOUN
gs-3960	667	3	,	,	PUNCT
gs-3960	667	4	nana	nana	PROPN
gs-3960	667	5	gorgaslidze	gorgaslidze	PROPN
gs-3960	667	6	,	,	PUNCT
gs-3960	667	7	margarita	margarita	PROPN
gs-3960	667	8	beglaryan	beglaryan	PROPN
gs-3960	667	9	,	,	PUNCT
gs-3960	667	10	luiza	luiza	PROPN
gs-3960	667	11	gabunia	gabunia	PROPN
gs-3960	667	12	,	,	PUNCT
gs-3960	667	13	nato	nato	PROPN
gs-3960	667	14	alavidze	alavidze	PROPN
gs-3960	667	15	,	,	PUNCT
gs-3960	667	16	nino	nino	PROPN
gs-3960	667	17	abuladze	abuladze	PROPN
gs-3960	667	18	,	,	PUNCT
gs-3960	667	19	marina	marina	PROPN
gs-3960	667	20	giorgobiani	giorgobiani	PROPN
gs-3960	667	21	,	,	PUNCT
gs-3960	667	22	marika	marika	PROPN
gs-3960	667	23	sulashvili	sulashvili	PROPN
gs-3960	667	24	,	,	PUNCT
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gs-3960	667	37	,	,	PUNCT
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gs-3960	667	39	issues	issue	NOUN
gs-3960	667	40	,	,	PUNCT
gs-3960	667	41	mycoecology	mycoecology	NOUN
gs-3960	667	42	,	,	PUNCT
gs-3960	667	43	(	(	PUNCT
gs-3960	667	44	march	march	PROPN
gs-3960	667	45	)	)	PUNCT
gs-3960	667	46	.	.	PUNCT
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gs-3960	668	2	.	.	NOUN
gs-3960	668	3	44	44	NUM
gs-3960	668	4	.	.	PUNCT
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gs-3960	669	2	,	,	PUNCT
gs-3960	669	3	d.	d.	PROPN
gs-3960	669	4	,	,	PUNCT
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gs-3960	669	6	,	,	PUNCT
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gs-3960	669	8	,	,	PUNCT
gs-3960	669	9	sulashvili	sulashvili	NOUN
gs-3960	669	10	,	,	PUNCT
gs-3960	669	11	n.	n.	NOUN
gs-3960	669	12	,	,	PUNCT
gs-3960	669	13	&	&	CCONJ
gs-3960	669	14	nozadze	nozadze	NOUN
gs-3960	669	15	,	,	PUNCT
gs-3960	669	16	m.	m.	NOUN
gs-3960	669	17	(	(	PUNCT
gs-3960	669	18	2023	2023	NUM
gs-3960	669	19	)	)	PUNCT
gs-3960	669	20	.	.	PUNCT
gs-3960	670	1	the	the	DET
gs-3960	670	2	features	feature	NOUN
gs-3960	670	3	and	and	CCONJ
gs-3960	670	4	role	role	NOUN
gs-3960	670	5	of	of	ADP
gs-3960	670	6	shp2	shp2	ADJ
gs-3960	670	7	protein	protein	NOUN
gs-3960	670	8	in	in	ADP
gs-3960	670	9	postnatal	postnatal	ADJ
gs-3960	670	10	muscle	muscle	NOUN
gs-3960	670	11	development	development	NOUN
gs-3960	670	12	.	.	PUNCT
gs-3960	671	1	scientific	scientific	ADJ
gs-3960	671	2	journal	journal	NOUN
gs-3960	671	3	georgian	georgian	NOUN
gs-3960	671	4	scientists/	scientists/	NUM
gs-3960	671	5	.	.	PUNCT
gs-3960	672	1	7	7	NUM
gs-3960	672	2	n	n	PRON
gs-3960	672	3	3	3	NUM
gs-3960	672	4	,	,	PUNCT
gs-3960	672	5	2025	2025	NUM
gs-3960	672	6	438	438	NUM
gs-3960	672	7	45	45	NUM
gs-3960	672	8	.	.	PUNCT
gs-3960	672	9	sulashvili	sulashvili	NOUN
gs-3960	672	10	,	,	PUNCT
gs-3960	672	11	n.	n.	NOUN
gs-3960	672	12	,	,	PUNCT
gs-3960	672	13	beglaryan	beglaryan	ADJ
gs-3960	672	14	,	,	PUNCT
gs-3960	672	15	m.	m.	NOUN
gs-3960	672	16	,	,	PUNCT
gs-3960	672	17	gorgaslidze	gorgaslidze	PROPN
gs-3960	672	18	,	,	PUNCT
gs-3960	672	19	n.	n.	PROPN
gs-3960	672	20	,	,	PUNCT
gs-3960	672	21	kocharyan	kocharyan	PROPN
gs-3960	672	22	,	,	PUNCT
gs-3960	672	23	s.	s.	PROPN
gs-3960	672	24	,	,	PUNCT
gs-3960	672	25	chichoyan	chichoyan	PROPN
gs-3960	672	26	,	,	PUNCT
gs-3960	672	27	n.	n.	NOUN
gs-3960	672	28	,	,	PUNCT
gs-3960	672	29	gabunia	gabunia	NOUN
gs-3960	672	30	,	,	PUNCT
gs-3960	672	31	l.	l.	PROPN
gs-3960	672	32	,	,	PUNCT
gs-3960	672	33	zarnadze	zarnadze	PROPN
gs-3960	672	34	,	,	PUNCT
gs-3960	672	35	s.	s.	PROPN
gs-3960	672	36	(	(	PUNCT
gs-3960	672	37	davit	davit	PROPN
gs-3960	672	38	)	)	PUNCT
gs-3960	672	39	.	.	PUNCT
gs-3960	673	1	(	(	PUNCT
gs-3960	673	2	2023	2023	NUM
gs-3960	673	3	)	)	PUNCT
gs-3960	673	4	.	.	PUNCT
gs-3960	674	1	the	the	DET
gs-3960	674	2	disclosure	disclosure	NOUN
gs-3960	674	3	of	of	ADP
gs-3960	674	4	features	feature	NOUN
gs-3960	674	5	,	,	PUNCT
gs-3960	674	6	characteristics	characteristic	NOUN
gs-3960	674	7	,	,	PUNCT
gs-3960	674	8	possibilities	possibility	NOUN
gs-3960	674	9	and	and	CCONJ
gs-3960	674	10	specialties	specialty	NOUN
gs-3960	674	11	of	of	ADP
gs-3960	674	12	clinical	clinical	ADJ
gs-3960	674	13	pharmacists	pharmacist	NOUN
gs-3960	674	14	as	as	ADP
gs-3960	674	15	mediator	mediator	NOUN
gs-3960	674	16	among	among	ADP
gs-3960	674	17	doctors	doctor	NOUN
gs-3960	674	18	and	and	CCONJ
gs-3960	674	19	patients	patient	NOUN
gs-3960	674	20	for	for	ADP
gs-3960	674	21	enhancement	enhancement	NOUN
gs-3960	674	22	public	public	ADJ
gs-3960	674	23	health	health	NOUN
gs-3960	674	24	sector	sector	NOUN
gs-3960	674	25	in	in	ADP
gs-3960	674	26	a	a	DET
gs-3960	674	27	global	global	ADJ
gs-3960	674	28	https://doi.org/10.52340/jecm.2023.04.15	https://doi.org/10.52340/jecm.2023.04.15	PROPN
gs-3960	674	29	46	46	NUM
gs-3960	674	30	.	.	PUNCT
gs-3960	675	1	sulashvili	sulashvili	PROPN
gs-3960	675	2	n	n	CCONJ
gs-3960	675	3	,	,	PUNCT
gs-3960	675	4	davitashvili	davitashvili	PROPN
gs-3960	675	5	m	m	PROPN
gs-3960	675	6	,	,	PUNCT
gs-3960	675	7	gorgaslidze	gorgaslidze	ADJ
gs-3960	675	8	n	n	CCONJ
gs-3960	675	9	,	,	PUNCT
gs-3960	675	10	gabunia	gabunia	NOUN
gs-3960	675	11	l	l	NOUN
gs-3960	675	12	,	,	PUNCT
gs-3960	675	13	beglaryan	beglaryan	PROPN
gs-3960	675	14	m	m	PROPN
gs-3960	675	15	,	,	PUNCT
gs-3960	675	16	alavidze	alavidze	PROPN
gs-3960	675	17	n	n	CCONJ
gs-3960	675	18	,	,	PUNCT
gs-3960	675	19	et	et	PROPN
gs-3960	675	20	al	al	PROPN
gs-3960	675	21	.	.	PUNCT
gs-3960	676	1	the	the	DET
gs-3960	676	2	scientific	scientific	ADJ
gs-3960	676	3	discussion	discussion	NOUN
gs-3960	676	4	of	of	ADP
gs-3960	676	5	some	some	DET
gs-3960	676	6	issues	issue	NOUN
gs-3960	676	7	of	of	ADP
gs-3960	676	8	features	feature	NOUN
gs-3960	676	9	and	and	CCONJ
gs-3960	676	10	challenges	challenge	NOUN
gs-3960	676	11	of	of	ADP
gs-3960	676	12	using	use	VERB
gs-3960	676	13	of	of	ADP
gs-3960	676	14	car	car	NOUN
gs-3960	676	15	-	-	PUNCT
gs-3960	676	16	t	t	NOUN
gs-3960	676	17	cells	cell	NOUN
gs-3960	676	18	in	in	ADP
gs-3960	676	19	immunotherapy	immunotherapy	NOUN
gs-3960	676	20	.	.	PUNCT
gs-3960	677	1	gs	gs	PROPN
gs-3960	677	2	2024	2024	NUM
gs-3960	677	3	;	;	PUNCT
gs-3960	677	4	6(4):263	6(4):263	NUM
gs-3960	677	5	-	-	SYM
gs-3960	677	6	90	90	NUM
gs-3960	677	7	.	.	PUNCT
gs-3960	678	1	https://journals.4science.ge/index.php/gs/article/view/3214	https://journals.4science.ge/index.php/gs/article/view/3214	PROPN
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gs-3960	679	2	.	.	PUNCT
gs-3960	680	1	https://doi.org/10.52340/gs.2025.07.01.26	https://doi.org/10.52340/gs.2025.07.01.26	NOUN
gs-3960	680	2	.	.	NOUN
gs-3960	681	1	48	48	NUM
gs-3960	681	2	.	.	X
gs-3960	682	1	49	49	NUM
gs-3960	682	2	.	.	PUNCT
gs-3960	683	1	aphkhazava	aphkhazava	PROPN
gs-3960	683	2	,	,	PUNCT
gs-3960	683	3	david	david	PROPN
gs-3960	683	4	,	,	PUNCT
gs-3960	683	5	tamar	tamar	PROPN
gs-3960	683	6	tuphinashvili	tuphinashvili	PROPN
gs-3960	683	7	,	,	PUNCT
gs-3960	683	8	nodar	nodar	NOUN
gs-3960	683	9	sulashvili	sulashvili	NOUN
gs-3960	683	10	,	,	PUNCT
gs-3960	683	11	and	and	CCONJ
gs-3960	683	12	maia	maia	PROPN
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gs-3960	683	14	.	.	PROPN
gs-3960	684	1	50	50	NUM
gs-3960	684	2	.	.	PUNCT
gs-3960	685	1	sulashvili	sulashvili	PROPN
gs-3960	685	2	n	n	CCONJ
gs-3960	685	3	,	,	PUNCT
gs-3960	685	4	gorgaslidze	gorgaslidze	ADJ
gs-3960	685	5	n	n	CCONJ
gs-3960	685	6	,	,	PUNCT
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gs-3960	685	8	l	l	NOUN
gs-3960	685	9	,	,	PUNCT
gs-3960	685	10	giorgobiani	giorgobiani	PROPN
gs-3960	685	11	m	m	PROPN
gs-3960	685	12	,	,	PUNCT
gs-3960	685	13	ratiani	ratiani	PROPN
gs-3960	685	14	l.	l.	PROPN
gs-3960	685	15	manifestation	manifestation	PROPN
gs-3960	685	16	of	of	ADP
gs-3960	685	17	the	the	DET
gs-3960	685	18	particularities	particularity	NOUN
gs-3960	685	19	of	of	ADP
gs-3960	685	20	the	the	DET
gs-3960	685	21	usage	usage	NOUN
gs-3960	685	22	features	feature	NOUN
gs-3960	685	23	of	of	ADP
gs-3960	685	24	monoclonal	monoclonal	NOUN
gs-3960	685	25	antibodies	antibody	NOUN
gs-3960	685	26	in	in	ADP
gs-3960	685	27	various	various	ADJ
gs-3960	685	28	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-3960	685	29	applications	application	NOUN
gs-3960	685	30	.	.	PUNCT
gs-3960	686	1	jecmg	jecmg	NOUN
gs-3960	687	1	[	[	X
gs-3960	687	2	internet	internet	NOUN
gs-3960	687	3	]	]	X
gs-3960	687	4	.	.	PUNCT
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gs-3960	688	2	nov	nov	PROPN
gs-3960	688	3	.	.	PROPN
gs-3960	688	4	26	26	NUM
gs-3960	688	5	[	[	X
gs-3960	688	6	cited	cite	VERB
gs-3960	688	7	2025	2025	NUM
gs-3960	688	8	jul	jul	PROPN
gs-3960	688	9	.	.	PROPN
gs-3960	688	10	12];(4):52	12];(4):52	NUM
gs-3960	688	11	-	-	SYM
gs-3960	688	12	7	7	NUM
gs-3960	688	13	.	.	PUNCT
gs-3960	688	14	available	available	ADJ
gs-3960	688	15	from	from	ADP
gs-3960	688	16	:	:	PUNCT
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gs-3960	689	2	.	.	X
gs-3960	690	1	aphkhazava	aphkhazava	PROPN
gs-3960	690	2	,	,	PUNCT
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gs-3960	690	14	52	52	NUM
gs-3960	690	15	.	.	PUNCT
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gs-3960	691	2	,	,	PUNCT
gs-3960	691	3	david	david	PROPN
gs-3960	691	4	,	,	PUNCT
gs-3960	691	5	nodar	nodar	PROPN
gs-3960	691	6	sulashvili	sulashvili	NOUN
gs-3960	691	7	,	,	PUNCT
gs-3960	691	8	ia	ia	PROPN
gs-3960	691	9	egnatievi	egnatievi	PROPN
gs-3960	691	10	,	,	PUNCT
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gs-3960	691	14	and	and	CCONJ
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gs-3960	691	19	nodar	nodar	ADV
gs-3960	691	20	,	,	PUNCT
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gs-3960	691	23	,	,	PUNCT
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gs-3960	691	26	,	,	PUNCT
gs-3960	691	27	ia	ia	PROPN
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gs-3960	691	29	,	,	PUNCT
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gs-3960	691	31	giorgobiani	giorgobiani	PROPN
gs-3960	691	32	,	,	PUNCT
gs-3960	691	33	luiza	luiza	PROPN
gs-3960	691	34	gabunia	gabunia	PROPN
gs-3960	691	35	,	,	PUNCT
gs-3960	691	36	nana	nana	PROPN
gs-3960	691	37	gorgaslidze	gorgaslidze	PROPN
gs-3960	691	38	,	,	PUNCT
gs-3960	691	39	magda	magda	PROPN
gs-3960	691	40	davitashvili	davitashvili	PROPN
gs-3960	691	41	,	,	PUNCT
gs-3960	691	42	ada	ada	PROPN
gs-3960	691	43	(	(	PUNCT
gs-3960	691	44	adel	adel	PROPN
gs-3960	691	45	)	)	PUNCT
gs-3960	691	46	aspects	aspect	NOUN
gs-3960	691	47	of	of	ADP
gs-3960	691	48	modern	modern	ADJ
gs-3960	691	49	advancing	advance	VERB
gs-3960	691	50	innovation	innovation	NOUN
gs-3960	691	51	of	of	ADP
gs-3960	691	52	learning	learning	NOUN
gs-3960	691	53	and	and	CCONJ
gs-3960	691	54	teaching	teaching	NOUN
gs-3960	691	55	methods	method	NOUN
gs-3960	691	56	and	and	CCONJ
gs-3960	691	57	pedagogical	pedagogical	ADJ
gs-3960	691	58	approaches	approach	NOUN
gs-3960	691	59	in	in	ADP
gs-3960	691	60	higher	high	ADJ
gs-3960	691	61	education	education	NOUN
gs-3960	691	62	institutions	institution	NOUN
gs-3960	691	63	in	in	ADP
gs-3960	691	64	medical	medical	ADJ
gs-3960	691	65	educational	educational	ADJ
gs-3960	691	66	study	study	NOUN
gs-3960	691	67	programs	program	NOUN
gs-3960	691	68	georgian	georgian	NOUN
gs-3960	691	69	scientists/	scientists/	NUM
gs-3960	691	70	.	.	PUNCT
gs-3960	692	1	7	7	NUM
gs-3960	692	2	n	n	PRON
gs-3960	692	3	3	3	NUM
gs-3960	692	4	,	,	PUNCT
gs-3960	692	5	2025	2025	NUM
gs-3960	692	6	439	439	NUM
gs-3960	692	7	https://doi.org/10.52340/spectri.2024.10.01.12	https://doi.org/10.52340/spectri.2024.10.01.12	NOUN
gs-3960	692	8	.	.	PUNCT
gs-3960	693	1	54	54	NUM
gs-3960	693	2	.	.	PUNCT
gs-3960	694	1	gorgaslidze	gorgaslidze	PROPN
gs-3960	694	2	,	,	PUNCT
gs-3960	694	3	nana	nana	PROPN
gs-3960	694	4	,	,	PUNCT
gs-3960	694	5	nodar	nodar	NOUN
gs-3960	694	6	sulashvili	sulashvili	NOUN
gs-3960	694	7	,	,	PUNCT
gs-3960	694	8	luiza	luiza	PROPN
gs-3960	694	9	gabunia	gabunia	NOUN
gs-3960	694	10	,	,	PUNCT
gs-3960	694	11	temozolomide	temozolomide	ADP
gs-3960	694	12	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-3960	694	13	effects	effect	NOUN
gs-3960	694	14	in	in	ADP
gs-3960	694	15	brain	brain	NOUN
gs-3960	694	16	tumor	tumor	NOUN
gs-3960	694	17	(	(	PUNCT
gs-3960	694	18	november):62	november):62	NOUN
gs-3960	694	19	-	-	PUNCT
gs-3960	694	20	66	66	NUM
gs-3960	694	21	.	.	PUNCT
gs-3960	695	1	https://doi.org/10.52340/jecm.2023.04.16	https://doi.org/10.52340/jecm.2023.04.16	NUM
gs-3960	695	2	.	.	PUNCT
gs-3960	696	1	55	55	NUM
gs-3960	696	2	.	.	PUNCT
gs-3960	697	1	sulashvili	sulashvili	NOUN
gs-3960	697	2	,	,	PUNCT
gs-3960	697	3	nodar	nodar	ADV
gs-3960	697	4	,	,	PUNCT
gs-3960	697	5	margarita	margarita	PROPN
gs-3960	697	6	beglaryan	beglaryan	PROPN
gs-3960	697	7	,	,	PUNCT
gs-3960	697	8	nana	nana	PROPN
gs-3960	697	9	gorgaslidze	gorgaslidze	PROPN
gs-3960	697	10	,	,	PUNCT
gs-3960	697	11	seyran	seyran	PROPN
gs-3960	697	12	kocharyan	kocharyan	PROPN
gs-3960	697	13	,	,	PUNCT
gs-3960	697	14	naira	naira	PROPN
gs-3960	697	15	chichoyan	chichoyan	PROPN
gs-3960	697	16	,	,	PUNCT
gs-3960	697	17	luiza	luiza	PROPN
gs-3960	697	18	gabunia	gabunia	PROPN
gs-3960	697	19	,	,	PUNCT
gs-3960	697	20	characteristics	characteristic	NOUN
gs-3960	697	21	,	,	PUNCT
gs-3960	697	22	possibilities	possibility	NOUN
gs-3960	697	23	and	and	CCONJ
gs-3960	697	24	specialties	specialty	NOUN
gs-3960	697	25	of	of	ADP
gs-3960	697	26	clinical	clinical	ADJ
gs-3960	697	27	pharmacists	pharmacist	NOUN
gs-3960	697	28	as	as	ADP
gs-3960	697	29	mediator	mediator	NOUN
gs-3960	697	30	among	among	ADP
gs-3960	697	31	doctors	doctor	NOUN
gs-3960	697	32	and	and	CCONJ
gs-3960	697	33	patients	patient	NOUN
gs-3960	697	34	for	for	ADP
gs-3960	697	35	and	and	CCONJ
gs-3960	697	36	clinical	clinical	ADJ
gs-3960	697	37	medicine	medicine	NOUN
gs-3960	697	38	georgia	georgia	PROPN
gs-3960	697	39	,	,	PUNCT
gs-3960	697	40	no	no	INTJ
gs-3960	697	41	.	.	NOUN
gs-3960	697	42	4	4	NUM
gs-3960	697	43	(	(	PUNCT
gs-3960	697	44	november):57	november):57	NOUN
gs-3960	697	45	-	-	PUNCT
gs-3960	697	46	62	62	NUM
gs-3960	697	47	.	.	PUNCT
gs-3960	698	1	https://doi.org/10.52340/jecm.2023.04.15	https://doi.org/10.52340/jecm.2023.04.15	PROPN
gs-3960	698	2	.	.	PROPN
gs-3960	698	3	56	56	NUM
gs-3960	698	4	.	.	PUNCT
gs-3960	699	1	kvizhinadze	kvizhinadze	PROPN
gs-3960	699	2	,	,	PUNCT
gs-3960	699	3	natia	natia	PROPN
gs-3960	699	4	,	,	PUNCT
gs-3960	699	5	nino	nino	PROPN
gs-3960	699	6	intskirveli	intskirveli	PROPN
gs-3960	699	7	,	,	PUNCT
gs-3960	699	8	david	david	PROPN
gs-3960	699	9	topuria	topuria	PROPN
gs-3960	699	10	,	,	PUNCT
gs-3960	699	11	nana	nana	PROPN
gs-3960	699	12	medicine	medicine	PROPN
gs-3960	699	13	georgia	georgia	PROPN
gs-3960	699	14	,	,	PUNCT
gs-3960	699	15	no	no	INTJ
gs-3960	699	16	.	.	NOUN
gs-3960	699	17	4	4	NUM
gs-3960	699	18	(	(	PUNCT
gs-3960	699	19	november):17	november):17	NOUN
gs-3960	699	20	-	-	PUNCT
gs-3960	699	21	19	19	NUM
gs-3960	699	22	.	.	PUNCT
gs-3960	699	23	https://doi.org/10.52340/jecm.2023.04.03	https://doi.org/10.52340/jecm.2023.04.03	NUM
gs-3960	699	24	.	.	PROPN
gs-3960	700	1	57	57	NUM
gs-3960	700	2	.	.	PUNCT
gs-3960	700	3	sulashvili	sulashvili	NOUN
gs-3960	700	4	,	,	PUNCT
gs-3960	700	5	nodar	nodar	PROPN
gs-3960	700	6	,	,	PUNCT
gs-3960	700	7	nana	nana	PROPN
gs-3960	700	8	gorgaslidze	gorgaslidze	PROPN
gs-3960	700	9	,	,	PUNCT
gs-3960	700	10	margarita	margarita	PROPN
gs-3960	700	11	beglaryan	beglaryan	PROPN
gs-3960	700	12	,	,	PUNCT
gs-3960	700	13	luiza	luiza	PROPN
gs-3960	700	14	gabunia	gabunia	PROPN
gs-3960	700	15	,	,	PUNCT
gs-3960	700	16	naira	naira	PROPN
gs-3960	700	17	chichoyan	chichoyan	PROPN
gs-3960	700	18	,	,	PUNCT
gs-3960	700	19	marina	marina	PROPN
gs-3960	700	20	giorgobiani	giorgobiani	PROPN
gs-3960	700	21	,	,	PUNCT
gs-3960	700	22	talks	talk	NOUN
gs-3960	700	23	of	of	ADP
gs-3960	700	24	essential	essential	ADJ
gs-3960	700	25	issue	issue	NOUN
gs-3960	700	26	,	,	PUNCT
gs-3960	700	27	invocation	invocation	NOUN
gs-3960	700	28	,	,	PUNCT
gs-3960	700	29	perspectives	perspective	NOUN
gs-3960	700	30	,	,	PUNCT
gs-3960	700	31	inclinations	inclination	NOUN
gs-3960	700	32	and	and	CCONJ
gs-3960	700	33	clinical	clinical	ADJ
gs-3960	700	34	medicine	medicine	NOUN
gs-3960	700	35	georgia	georgia	PROPN
gs-3960	700	36	,	,	PUNCT
gs-3960	700	37	no	no	INTJ
gs-3960	700	38	.	.	NOUN
gs-3960	700	39	7	7	NUM
gs-3960	700	40	(	(	PUNCT
gs-3960	700	41	october	october	PROPN
gs-3960	700	42	)	)	PUNCT
gs-3960	700	43	.	.	PUNCT
gs-3960	701	1	https://doi.org/10.52340/jecm.2022.07.09	https://doi.org/10.52340/jecm.2022.07.09	PROPN
gs-3960	701	2	.	.	PUNCT
gs-3960	702	1	58	58	NUM
gs-3960	702	2	.	.	PUNCT
gs-3960	703	1	sulashvili	sulashvili	NOUN
gs-3960	703	2	,	,	PUNCT
gs-3960	703	3	nodar	nodar	INTJ
gs-3960	703	4	,	,	PUNCT
gs-3960	703	5	margarita	margarita	PROPN
gs-3960	703	6	beglaryan	beglaryan	PROPN
gs-3960	703	7	,	,	PUNCT
gs-3960	703	8	nana	nana	PROPN
gs-3960	703	9	gorgaslidze	gorgaslidze	PROPN
gs-3960	703	10	,	,	PUNCT
gs-3960	703	11	seyran	seyran	PROPN
gs-3960	703	12	kocharyan	kocharyan	PROPN
gs-3960	703	13	,	,	PUNCT
gs-3960	703	14	naira	naira	PROPN
gs-3960	703	15	chichoyan	chichoyan	PROPN
gs-3960	703	16	,	,	PUNCT
gs-3960	703	17	luiza	luiza	PROPN
gs-3960	703	18	gabunia	gabunia	PROPN
gs-3960	703	19	,	,	PUNCT
gs-3960	703	20	natia	natia	PROPN
gs-3960	703	21	kvizhinadze	kvizhinadze	PROPN
gs-3960	703	22	,	,	PUNCT
gs-3960	703	23	marina	marina	PROPN
gs-3960	703	24	giorgobiani	giorgobiani	PROPN
gs-3960	703	25	,	,	PUNCT
gs-3960	703	26	irine	irine	NOUN
gs-3960	703	27	zarnadze	zarnadze	NOUN
gs-3960	703	28	,	,	PUNCT
gs-3960	703	29	and	and	CCONJ
gs-3960	703	30	specificities	specificity	NOUN
gs-3960	703	31	of	of	ADP
gs-3960	703	32	pharmacist	pharmacist	NOUN
gs-3960	703	33	occupational	occupational	ADJ
gs-3960	703	34	and	and	CCONJ
gs-3960	703	35	higher	high	ADJ
gs-3960	703	36	medicalpharmaceutical	medicalpharmaceutical	ADJ
gs-3960	703	37	educational	educational	ADJ
gs-3960	703	38	manifestation	manifestation	NOUN
gs-3960	703	39	outlooks	outlook	NOUN
gs-3960	703	40	in	in	ADP
gs-3960	703	41	https://doi.org/10.52340/jecm.2022.07.08	https://doi.org/10.52340/jecm.2022.07.08	NUM
gs-3960	703	42	.	.	PUNCT
gs-3960	704	1	59	59	NUM
gs-3960	704	2	.	.	PUNCT
gs-3960	704	3	gorgaslidze	gorgaslidze	PROPN
gs-3960	704	4	,	,	PUNCT
gs-3960	704	5	nana	nana	PROPN
gs-3960	704	6	,	,	PUNCT
gs-3960	704	7	shafiga	shafiga	PROPN
gs-3960	704	8	topchiyeva	topchiyeva	PROPN
gs-3960	704	9	,	,	PUNCT
gs-3960	704	10	marina	marina	NOUN
gs-3960	704	11	pharmaceutical	pharmaceutical	NOUN
gs-3960	704	12	marketing	marketing	NOUN
gs-3960	704	13	on	on	ADP
gs-3960	704	14	the	the	DET
gs-3960	704	15	society	society	NOUN
gs-3960	704	16	and	and	CCONJ
gs-3960	704	17	individual	individual	ADJ
gs-3960	704	18	medicine	medicine	NOUN
gs-3960	704	19	georgia	georgia	PROPN
gs-3960	704	20	,	,	PUNCT
gs-3960	704	21	no	no	INTJ
gs-3960	704	22	.	.	NOUN
gs-3960	704	23	7	7	NUM
gs-3960	704	24	(	(	PUNCT
gs-3960	704	25	october	october	PROPN
gs-3960	704	26	)	)	PUNCT
gs-3960	704	27	.	.	PUNCT
gs-3960	705	1	https://doi.org/10.52340/jecm.2022.07.07	https://doi.org/10.52340/jecm.2022.07.07	X
gs-3960	705	2	.	.	PUNCT
gs-3960	706	1	georgian	georgian	PROPN
gs-3960	706	2	scientists/	scientists/	NUM
gs-3960	706	3	.	.	PUNCT
gs-3960	707	1	7	7	NUM
gs-3960	707	2	n	n	PRON
gs-3960	707	3	3	3	NUM
gs-3960	707	4	,	,	PUNCT
gs-3960	707	5	2025	2025	NUM
gs-3960	707	6	440	440	NUM
gs-3960	707	7	60	60	NUM
gs-3960	707	8	.	.	PUNCT
gs-3960	708	1	features	feature	NOUN
gs-3960	708	2	of	of	ADP
gs-3960	708	3	the	the	DET
gs-3960	708	4	pharmaceutical	pharmaceutical	ADJ
gs-3960	708	5	market	market	NOUN
gs-3960	708	6	and	and	CCONJ
gs-3960	708	7	its	its	PRON
gs-3960	708	8	outlooks	outlook	NOUN
gs-3960	708	9	in	in	ADP
gs-3960	708	10	https://doi.org/10.52340/jecm.2022.07.06	https://doi.org/10.52340/jecm.2022.07.06	PROPN
gs-3960	708	11	.	.	PROPN
gs-3960	708	12	61	61	NUM
gs-3960	708	13	.	.	PUNCT
gs-3960	709	1	nana	nana	PROPN
gs-3960	709	2	gorgaslidze	gorgaslidze	PROPN
gs-3960	709	3	,	,	PUNCT
gs-3960	709	4	nodar	nodar	NOUN
gs-3960	709	5	sulashvili	sulashvili	NOUN
gs-3960	709	6	,	,	PUNCT
gs-3960	709	7	marina	marina	NOUN
gs-3960	709	8	giorgobiani	giorgobiani	PROPN
gs-3960	709	9	,	,	PUNCT
gs-3960	709	10	tea	tea	NOUN
gs-3960	709	11	zarkua	zarkua	NOUN
gs-3960	709	12	,	,	PUNCT
gs-3960	709	13	nana	nana	PROPN
gs-3960	709	14	dugashvili	dugashvili	PROPN
gs-3960	709	15	.	.	PUNCT
gs-3960	710	1	the	the	DET
gs-3960	710	2	features	feature	NOUN
gs-3960	710	3	of	of	ADP
gs-3960	710	4	inspection	inspection	NOUN
gs-3960	710	5	and	and	CCONJ
gs-3960	710	6	monitoring	monitoring	NOUN
gs-3960	710	7	framework	framework	NOUN
gs-3960	710	8	for	for	ADP
gs-3960	710	9	professional	professional	ADJ
gs-3960	710	10	safety	safety	NOUN
gs-3960	710	11	,	,	PUNCT
gs-3960	710	12	sanitary	sanitary	NOUN
gs-3960	710	13	,	,	PUNCT
gs-3960	710	14	bioecological	bioecological	ADJ
gs-3960	710	15	,	,	PUNCT
gs-3960	710	16	preventive	preventive	ADJ
gs-3960	710	17	and	and	CCONJ
gs-3960	710	18	hygienic	hygienic	ADJ
gs-3960	710	19	novel	novel	ADJ
gs-3960	710	20	requirement	requirement	NOUN
gs-3960	710	21	issues	issue	NOUN
gs-3960	710	22	of	of	ADP
gs-3960	710	23	pharmaceutical	pharmaceutical	ADJ
gs-3960	710	24	organizations	organization	NOUN
gs-3960	710	25	in	in	ADP
gs-3960	710	26	the	the	DET
gs-3960	710	27	context	context	NOUN
gs-3960	710	28	of	of	ADP
gs-3960	710	29	the	the	DET
gs-3960	710	30	covid-19	covid-19	PROPN
gs-3960	710	31	pandemic	pandemic	NOUN
gs-3960	710	32	in	in	ADP
gs-3960	710	33	georgia	georgia	PROPN
gs-3960	710	34	.	.	PUNCT
gs-3960	711	1	jecmg	jecmg	PROPN
gs-3960	712	1	[	[	X
gs-3960	712	2	internet	internet	NOUN
gs-3960	712	3	]	]	PUNCT
gs-3960	712	4	.	.	PUNCT
gs-3960	713	1	2021	2021	NUM
gs-3960	713	2	oct	oct	PROPN
gs-3960	713	3	.	.	PROPN
gs-3960	713	4	19	19	NUM
gs-3960	714	1	[	[	X
gs-3960	714	2	cited	cite	VERB
gs-3960	714	3	2025	2025	NUM
gs-3960	714	4	jul	jul	PROPN
gs-3960	714	5	.	.	PUNCT
gs-3960	714	6	12];(5	12];(5	PROPN
gs-3960	714	7	-	-	PUNCT
gs-3960	714	8	6):426	6):426	NUM
gs-3960	714	9	.	.	PUNCT
gs-3960	715	1	available	available	ADJ
gs-3960	715	2	from	from	ADP
gs-3960	715	3	:	:	PUNCT
gs-3960	715	4	https://journals.4science.ge/index.php/jecm/article/view/576	https://journals.4science.ge/index.php/jecm/article/view/576	PROPN
gs-3960	715	5	.	.	PUNCT
gs-3960	716	1	62	62	NUM
gs-3960	716	2	.	.	PUNCT
gs-3960	717	1	sulashvili	sulashvili	NOUN
gs-3960	717	2	,	,	PUNCT
gs-3960	717	3	nodar	nodar	ADV
gs-3960	717	4	,	,	PUNCT
gs-3960	717	5	artashes	artashe	VERB
gs-3960	717	6	aznauryan	aznauryan	PROPN
gs-3960	717	7	,	,	PUNCT
gs-3960	717	8	anna	anna	PROPN
gs-3960	717	9	termarkosyan	termarkosyan	PROPN
gs-3960	717	10	,	,	PUNCT
gs-3960	717	11	nana	nana	PROPN
gs-3960	717	12	gorgaslidze	gorgaslidze	PROPN
gs-3960	717	13	,	,	PUNCT
gs-3960	717	14	seyran	seyran	PROPN
gs-3960	717	15	kocharyan	kocharyan	PROPN
gs-3960	717	16	,	,	PUNCT
gs-3960	717	17	irine	irine	NOUN
gs-3960	717	18	discussion	discussion	NOUN
gs-3960	717	19	of	of	ADP
gs-3960	717	20	specificites	specificite	NOUN
gs-3960	717	21	of	of	ADP
gs-3960	717	22	the	the	DET
gs-3960	717	23	role	role	NOUN
gs-3960	717	24	,	,	PUNCT
gs-3960	717	25	achievements	achievement	NOUN
gs-3960	717	26	,	,	PUNCT
gs-3960	717	27	innovations	innovation	NOUN
gs-3960	717	28	,	,	PUNCT
gs-3960	717	29	professional	professional	ADJ
gs-3960	717	30	and	and	CCONJ
gs-3960	717	31	enhancement	enhancement	NOUN
gs-3960	717	32	prospects	prospect	NOUN
gs-3960	717	33	of	of	ADP
gs-3960	717	34	pharmacists	pharmacist	NOUN
gs-3960	717	35	in	in	ADP
gs-3960	717	36	the	the	DET
gs-3960	717	37	experimental	experimental	ADJ
gs-3960	717	38	and	and	CCONJ
gs-3960	717	39	clinical	clinical	ADJ
gs-3960	717	40	medicine	medicine	NOUN
gs-3960	717	41	georgia	georgia	PROPN
gs-3960	717	42	,	,	PUNCT
gs-3960	717	43	no	no	INTJ
gs-3960	717	44	.	.	NOUN
gs-3960	717	45	5	5	NUM
gs-3960	717	46	-	-	SYM
gs-3960	717	47	6	6	NUM
gs-3960	717	48	(	(	PUNCT
gs-3960	717	49	october):38	october):38	PROPN
gs-3960	717	50	-	-	PUNCT
gs-3960	717	51	41	41	NUM
gs-3960	717	52	.	.	PUNCT
gs-3960	718	1	https://journals.4science.ge/index.php/jecm/article/view/575	https://journals.4science.ge/index.php/jecm/article/view/575	PROPN
gs-3960	718	2	.	.	PUNCT
gs-3960	719	1	63	63	NUM
gs-3960	719	2	.	.	PUNCT
gs-3960	720	1	https://doi.org/10.52340/gs.2025.07.01.26	https://doi.org/10.52340/gs.2025.07.01.26	NOUN
gs-3960	720	2	.	.	NOUN
gs-3960	720	3	64	64	NUM
gs-3960	720	4	.	.	PUNCT
gs-3960	721	1	sulashvili	sulashvili	NOUN
gs-3960	721	2	,	,	PUNCT
gs-3960	721	3	nodar	nodar	PROPN
gs-3960	721	4	,	,	PUNCT
gs-3960	721	5	nana	nana	PROPN
gs-3960	721	6	gorgaslidze	gorgaslidze	PROPN
gs-3960	721	7	,	,	PUNCT
gs-3960	721	8	luiza	luiza	PROPN
gs-3960	721	9	gabunia	gabunia	PROPN
gs-3960	721	10	,	,	PUNCT
gs-3960	721	11	levan	levan	PROPN
gs-3960	721	12	ratiani	ratiani	PROPN
gs-3960	721	13	,	,	PUNCT
gs-3960	721	14	shorena	shorena	PROPN
gs-3960	721	15	khetsuriani	khetsuriani	PROPN
gs-3960	721	16	,	,	PUNCT
gs-3960	721	17	vira	vira	PROPN
gs-3960	721	18	kravchenko	kravchenko	PROPN
gs-3960	721	19	,	,	PUNCT
gs-3960	721	20	igor	igor	PROPN
gs-3960	721	21	seniuk	seniuk	NOUN
gs-3960	721	22	,	,	PUNCT
gs-3960	721	23	marina	marina	PROPN
gs-3960	721	24	giorgobiani	giorgobiani	PROPN
gs-3960	721	25	,	,	PUNCT
gs-3960	721	26	natia	natia	PROPN
gs-3960	721	27	kvizhinadze	kvizhinadze	PROPN
gs-3960	721	28	,	,	PUNCT
gs-3960	721	29	and	and	CCONJ
gs-3960	721	30	marika	marika	PROPN
gs-3960	721	31	issue	issue	NOUN
gs-3960	721	32	aspects	aspect	NOUN
gs-3960	721	33	of	of	ADP
gs-3960	721	34	new	new	ADJ
gs-3960	721	35	immunotherapy	immunotherapy	NOUN
gs-3960	721	36	challenges	challenge	NOUN
gs-3960	721	37	and	and	CCONJ
gs-3960	721	38	perspectives	perspective	NOUN
gs-3960	721	39	(	(	PUNCT
gs-3960	721	40	september):119	september):119	PROPN
gs-3960	721	41	-	-	PUNCT
gs-3960	721	42	21	21	NUM
gs-3960	721	43	.	.	PUNCT
gs-3960	722	1	https://doi.org/10.52340/jecm.2024.04.32	https://doi.org/10.52340/jecm.2024.04.32	PROPN
gs-3960	722	2	.	.	NOUN
gs-3960	723	1	65	65	NUM
gs-3960	723	2	.	.	PUNCT
gs-3960	723	3	sulashvili	sulashvili	NOUN
gs-3960	723	4	,	,	PUNCT
gs-3960	723	5	nodar	nodar	INTJ
gs-3960	723	6	,	,	PUNCT
gs-3960	723	7	sharon	sharon	PROPN
gs-3960	723	8	fernando	fernando	PROPN
gs-3960	723	9	,	,	PUNCT
gs-3960	723	10	awad	awad	PROPN
gs-3960	723	11	el	el	PROPN
gs-3960	723	12	-	-	PUNCT
gs-3960	723	13	hakeem	hakeem	PROPN
gs-3960	723	14	,	,	PUNCT
gs-3960	723	15	luiza	luiza	PROPN
gs-3960	723	16	gabunia	gabunia	PROPN
gs-3960	723	17	,	,	PUNCT
gs-3960	723	18	nana	nana	PROPN
gs-3960	723	19	gorgaslidze	gorgaslidze	PROPN
gs-3960	723	20	,	,	PUNCT
gs-3960	723	21	margarita	margarita	PROPN
gs-3960	723	22	beglaryan	beglaryan	PROPN
gs-3960	723	23	,	,	PUNCT
gs-3960	723	24	lali	lali	PROPN
gs-3960	723	25	patsia	patsia	PROPN
gs-3960	723	26	,	,	PUNCT
gs-3960	723	27	natia	natia	PROPN
gs-3960	723	28	kvizhinadze	kvizhinadze	PROPN
gs-3960	723	29	,	,	PUNCT
gs-3960	723	30	and	and	CCONJ
gs-3960	723	31	marika	marika	PROPN
gs-3960	723	32	real	real	ADJ
gs-3960	723	33	-	-	PUNCT
gs-3960	723	34	time	time	NOUN
gs-3960	723	35	monitoring	monitoring	NOUN
gs-3960	723	36	and	and	CCONJ
gs-3960	723	37	pharmacotherapy	pharmacotherapy	NOUN
gs-3960	723	38	strategies	strategy	NOUN
gs-3960	723	39	:	:	PUNCT
gs-3960	723	40	innovations	innovation	NOUN
gs-3960	723	41	,	,	PUNCT
gs-3960	723	42	outcomes	outcome	NOUN
gs-3960	723	43	,	,	PUNCT
gs-3960	723	44	clinical	clinical	ADJ
gs-3960	723	45	impact	impact	NOUN
gs-3960	723	46	and	and	CCONJ
gs-3960	723	47	future	future	ADJ
gs-3960	723	48	directions	direction	NOUN
gs-3960	723	49	in	in	ADP
gs-3960	723	50	https://doi.org/10.52340/gs.2025.07.02.36	https://doi.org/10.52340/gs.2025.07.02.36	NUM
gs-3960	723	51	.	.	PUNCT
gs-3960	724	1	66	66	NUM
gs-3960	724	2	.	.	PUNCT
gs-3960	725	1	sulashvili	sulashvili	PROPN
gs-3960	725	2	n	n	PROPN
gs-3960	725	3	,	,	PUNCT
gs-3960	725	4	jadhav	jadhav	PROPN
gs-3960	725	5	rd	rd	PROPN
gs-3960	725	6	,	,	PUNCT
gs-3960	725	7	beglaryan	beglaryan	PROPN
gs-3960	725	8	m	m	PROPN
gs-3960	725	9	,	,	PUNCT
gs-3960	725	10	gabunia	gabunia	NOUN
gs-3960	725	11	l	l	NOUN
gs-3960	725	12	,	,	PUNCT
gs-3960	725	13	gorgaslidze	gorgaslidze	ADJ
gs-3960	725	14	n	n	CCONJ
gs-3960	725	15	,	,	PUNCT
gs-3960	725	16	alavidze	alavidze	PROPN
gs-3960	725	17	n	n	CCONJ
gs-3960	725	18	,	,	PUNCT
gs-3960	725	19	et	et	PROPN
gs-3960	725	20	al	al	PROPN
gs-3960	725	21	.	.	PUNCT
gs-3960	726	1	the	the	DET
gs-3960	726	2	scientific	scientific	ADJ
gs-3960	726	3	discussion	discussion	NOUN
gs-3960	726	4	of	of	ADP
gs-3960	726	5	key	key	ADJ
gs-3960	726	6	issue	issue	NOUN
gs-3960	726	7	aspects	aspect	NOUN
gs-3960	726	8	of	of	ADP
gs-3960	726	9	immunopathogenesis	immunopathogenesis	NOUN
gs-3960	726	10	and	and	CCONJ
gs-3960	726	11	pharmacological	pharmacological	NOUN
gs-3960	726	12	properties	property	NOUN
gs-3960	726	13	and	and	CCONJ
gs-3960	726	14	profiles	profile	NOUN
gs-3960	726	15	in	in	ADP
gs-3960	726	16	relation	relation	NOUN
gs-3960	726	17	to	to	ADP
gs-3960	726	18	adverse	adverse	ADJ
gs-3960	726	19	drug	drug	NOUN
gs-3960	726	20	reactions	reaction	NOUN
gs-3960	726	21	challenges	challenge	NOUN
gs-3960	726	22	,	,	PUNCT
gs-3960	726	23	focus	focus	VERB
gs-3960	726	24	georgian	georgian	NOUN
gs-3960	726	25	scientists/	scientists/	NUM
gs-3960	726	26	.	.	PUNCT
gs-3960	727	1	7	7	NUM
gs-3960	727	2	n	n	PRON
gs-3960	727	3	3	3	NUM
gs-3960	727	4	,	,	PUNCT
gs-3960	727	5	2025	2025	NUM
gs-3960	727	6	441	441	NUM
gs-3960	727	7	on	on	ADP
gs-3960	727	8	multidimensional	multidimensional	ADJ
gs-3960	727	9	drug	drug	NOUN
gs-3960	727	10	-	-	PUNCT
gs-3960	727	11	induced	induce	VERB
gs-3960	727	12	eosinophilia	eosinophilia	NOUN
gs-3960	727	13	and	and	CCONJ
gs-3960	727	14	systemic	systemic	ADJ
gs-3960	727	15	syndrome	syndrome	NOUN
gs-3960	727	16	.	.	PUNCT
gs-3960	728	1	gs	gs	X
gs-3960	729	1	[	[	X
gs-3960	729	2	internet	internet	NOUN
gs-3960	729	3	]	]	X
gs-3960	729	4	.	.	PUNCT
gs-3960	730	1	2025	2025	NUM
gs-3960	730	2	jul	jul	NOUN
gs-3960	730	3	.	.	PROPN
gs-3960	730	4	11	11	NUM
gs-3960	731	1	[	[	X
gs-3960	731	2	cited	cite	VERB
gs-3960	731	3	2025	2025	NUM
gs-3960	731	4	jul	jul	PROPN
gs-3960	731	5	.	.	PUNCT
gs-3960	732	1	12];7(3):141	12];7(3):141	NUM
gs-3960	732	2	-	-	SYM
gs-3960	732	3	79	79	NUM
gs-3960	732	4	.	.	PUNCT
gs-3960	733	1	available	available	ADJ
gs-3960	733	2	from	from	ADP
gs-3960	733	3	:	:	PUNCT
gs-3960	733	4	https://journals.4science.ge/index.php/gs/article/view/3919	https://journals.4science.ge/index.php/gs/article/view/3919	NOUN
gs-3960	733	5	.	.	NOUN
gs-3960	733	6	67	67	NUM
gs-3960	733	7	.	.	PUNCT
gs-3960	734	1	sulashvili	sulashvili	NOUN
gs-3960	734	2	,	,	PUNCT
gs-3960	734	3	nodar	nodar	INTJ
gs-3960	734	4	,	,	PUNCT
gs-3960	734	5	nato	nato	PROPN
gs-3960	734	6	alavidze	alavidze	PROPN
gs-3960	734	7	,	,	PUNCT
gs-3960	734	8	maka	maka	PROPN
gs-3960	734	9	buleishvili	buleishvili	PROPN
gs-3960	734	10	,	,	PUNCT
gs-3960	734	11	vira	vira	PROPN
gs-3960	734	12	kravchenko	kravchenko	PROPN
gs-3960	734	13	,	,	PUNCT
gs-3960	734	14	marika	marika	PROPN
gs-3960	734	15	sulashvili	sulashvili	PROPN
gs-3960	734	16	,	,	PUNCT
gs-3960	734	17	igor	igor	NOUN
gs-3960	734	18	seniuk	seniuk	NOUN
gs-3960	734	19	,	,	PUNCT
gs-3960	734	20	tamar	tamar	PROPN
gs-3960	734	21	okropiridze	okropiridze	PROPN
gs-3960	734	22	,	,	PUNCT
gs-3960	734	23	marina	marina	PROPN
gs-3960	734	24	giorgobiani	giorgobiani	PROPN
gs-3960	734	25	,	,	PUNCT
gs-3960	734	26	lela	lela	PROPN
gs-3960	734	27	grigolia	grigolia	PROPN
gs-3960	734	28	,	,	PUNCT
gs-3960	734	29	and	and	CCONJ
gs-3960	734	30	global	global	ADJ
gs-3960	734	31	perspectives	perspective	NOUN
gs-3960	734	32	on	on	ADP
gs-3960	734	33	innovative	innovative	ADJ
gs-3960	734	34	teaching	teaching	NOUN
gs-3960	734	35	and	and	CCONJ
gs-3960	734	36	learning	learn	VERB
gs-3960	734	37	approach	approach	NOUN
gs-3960	734	38	strategies	strategy	NOUN
gs-3960	734	39	in	in	ADP
gs-3960	734	40	higher	high	ADJ
gs-3960	734	41	medical	medical	ADJ
gs-3960	734	42	education	education	NOUN
gs-3960	734	43	:	:	PUNCT
gs-3960	734	44	advancing	advance	VERB
gs-3960	734	45	student	student	NOUN
gs-3960	734	46	-	-	PUNCT
gs-3960	734	47	centered	center	VERB
gs-3960	734	48	practices	practice	NOUN
gs-3960	734	49	,	,	PUNCT
gs-3960	734	50	technology	technology	NOUN
gs-3960	734	51	integration	integration	NOUN
gs-3960	734	52	and	and	CCONJ
gs-3960	734	53	https://doi.org/10.52340/spectri.2024.10.01.11	https://doi.org/10.52340/spectri.2024.10.01.11	PROPN
gs-3960	734	54	.	.	PROPN
gs-3960	734	55	68	68	NUM
gs-3960	734	56	.	.	PUNCT
gs-3960	735	1	sulashvili	sulashvili	NOUN
gs-3960	735	2	,	,	PUNCT
gs-3960	735	3	nodar	nodar	PROPN
gs-3960	735	4	,	,	PUNCT
gs-3960	735	5	nana	nana	PROPN
gs-3960	735	6	gorgaslidze	gorgaslidze	PROPN
gs-3960	735	7	,	,	PUNCT
gs-3960	735	8	margarita	margarita	PROPN
gs-3960	735	9	beglaryan	beglaryan	PROPN
gs-3960	735	10	,	,	PUNCT
gs-3960	735	11	luiza	luiza	PROPN
gs-3960	735	12	gabunia	gabunia	PROPN
gs-3960	735	13	,	,	PUNCT
gs-3960	735	14	natia	natia	PROPN
gs-3960	735	15	kvizhinadze	kvizhinadze	PROPN
gs-3960	735	16	,	,	PUNCT
gs-3960	735	17	tea	tea	NOUN
gs-3960	735	18	zarkua	zarkua	NOUN
gs-3960	735	19	,	,	PUNCT
gs-3960	735	20	marina	marina	PROPN
gs-3960	735	21	manifestation	manifestation	PROPN
gs-3960	735	22	of	of	ADP
gs-3960	735	23	characteristics	characteristic	NOUN
gs-3960	735	24	,	,	PUNCT
gs-3960	735	25	opportunities	opportunity	NOUN
gs-3960	735	26	and	and	CCONJ
gs-3960	735	27	challenges	challenge	NOUN
gs-3960	735	28	of	of	ADP
gs-3960	735	29	electronic	electronic	ADJ
gs-3960	735	30	systems	system	NOUN
gs-3960	735	31	and	and	CCONJ
gs-3960	735	32	digital	digital	ADJ
gs-3960	735	33	intelligence	intelligence	NOUN
gs-3960	735	34	using	use	VERB
gs-3960	735	35	in	in	ADP
gs-3960	735	36	(	(	PUNCT
gs-3960	735	37	september):122	september):122	PROPN
gs-3960	735	38	-	-	PUNCT
gs-3960	735	39	25	25	NUM
gs-3960	735	40	.	.	PUNCT
gs-3960	736	1	https://doi.org/10.52340/jecm.2024.04.33	https://doi.org/10.52340/jecm.2024.04.33	PROPN
gs-3960	736	2	.	.	PROPN
gs-3960	737	1	69	69	NUM
gs-3960	737	2	.	.	PUNCT
gs-3960	738	1	sulashvili	sulashvili	PROPN
gs-3960	738	2	n	n	CCONJ
gs-3960	738	3	,	,	PUNCT
gs-3960	738	4	davitashvili	davitashvili	PROPN
gs-3960	738	5	m	m	PROPN
gs-3960	738	6	,	,	PUNCT
gs-3960	738	7	gorgaslidze	gorgaslidze	ADJ
gs-3960	738	8	n	n	CCONJ
gs-3960	738	9	,	,	PUNCT
gs-3960	738	10	gabunia	gabunia	NOUN
gs-3960	738	11	l	l	NOUN
gs-3960	738	12	,	,	PUNCT
gs-3960	738	13	beglaryan	beglaryan	PROPN
gs-3960	738	14	m	m	PROPN
gs-3960	738	15	,	,	PUNCT
gs-3960	738	16	alavidze	alavidze	PROPN
gs-3960	738	17	n	n	CCONJ
gs-3960	738	18	,	,	PUNCT
gs-3960	738	19	et	et	PROPN
gs-3960	738	20	al	al	PROPN
gs-3960	738	21	.	.	PUNCT
gs-3960	739	1	the	the	DET
gs-3960	739	2	scientific	scientific	ADJ
gs-3960	739	3	discussion	discussion	NOUN
gs-3960	739	4	of	of	ADP
gs-3960	739	5	some	some	DET
gs-3960	739	6	issues	issue	NOUN
gs-3960	739	7	of	of	ADP
gs-3960	739	8	features	feature	NOUN
gs-3960	739	9	and	and	CCONJ
gs-3960	739	10	challenges	challenge	NOUN
gs-3960	739	11	of	of	ADP
gs-3960	739	12	using	use	VERB
gs-3960	739	13	of	of	ADP
gs-3960	739	14	car	car	NOUN
gs-3960	739	15	-	-	PUNCT
gs-3960	739	16	t	t	NOUN
gs-3960	739	17	cells	cell	NOUN
gs-3960	739	18	in	in	ADP
gs-3960	739	19	immunotherapy	immunotherapy	NOUN
gs-3960	739	20	.	.	PUNCT
gs-3960	740	1	gs	gs	X
gs-3960	741	1	[	[	X
gs-3960	741	2	internet	internet	NOUN
gs-3960	741	3	]	]	PUNCT
gs-3960	741	4	.	.	PUNCT
gs-3960	742	1	2024	2024	NUM
gs-3960	742	2	nov	nov	PROPN
gs-3960	742	3	.	.	PROPN
gs-3960	742	4	26	26	NUM
gs-3960	742	5	[	[	X
gs-3960	742	6	cited	cite	VERB
gs-3960	742	7	2025	2025	NUM
gs-3960	742	8	jul	jul	PROPN
gs-3960	742	9	.	.	PUNCT
gs-3960	742	10	12];6(4):263	12];6(4):263	NUM
gs-3960	742	11	-	-	SYM
gs-3960	742	12	90	90	NUM
gs-3960	742	13	.	.	PUNCT
gs-3960	743	1	available	available	ADJ
gs-3960	743	2	from	from	ADP
gs-3960	743	3	:	:	PUNCT
gs-3960	743	4	https://journals.4science.ge/index.php/gs/article/view/3214	https://journals.4science.ge/index.php/gs/article/view/3214	X
gs-3960	743	5	.	.	PUNCT
gs-3960	744	1	70	70	NUM
gs-3960	744	2	.	.	X
gs-3960	744	3	sulashvili	sulashvili	NOUN
gs-3960	744	4	,	,	PUNCT
gs-3960	744	5	nodar	nodar	INTJ
gs-3960	744	6	,	,	PUNCT
gs-3960	744	7	udgam	udgam	NOUN
gs-3960	744	8	yaduvanshi	yaduvanshi	PROPN
gs-3960	744	9	,	,	PUNCT
gs-3960	744	10	mohini	mohini	PROPN
gs-3960	744	11	yadav	yadav	PROPN
gs-3960	744	12	,	,	PUNCT
gs-3960	744	13	luiza	luiza	PROPN
gs-3960	744	14	gabunia	gabunia	NOUN
gs-3960	744	15	,	,	PUNCT
gs-3960	744	16	scientific	scientific	ADJ
gs-3960	744	17	discourse	discourse	NOUN
gs-3960	744	18	of	of	ADP
gs-3960	744	19	features	feature	NOUN
gs-3960	744	20	of	of	ADP
gs-3960	744	21	clinical	clinical	ADJ
gs-3960	744	22	use	use	NOUN
gs-3960	744	23	and	and	CCONJ
gs-3960	744	24	pharmacology	pharmacology	NOUN
gs-3960	744	25	of	of	ADP
gs-3960	744	26	vasoconstrictors	vasoconstrictor	NOUN
gs-3960	744	27	and	and	CCONJ
gs-3960	744	28	their	their	PRON
gs-3960	744	29	impact	impact	NOUN
gs-3960	744	30	on	on	ADP
gs-3960	744	31	cardiac	cardiac	ADJ
gs-3960	744	32	71	71	NUM
gs-3960	744	33	.	.	PUNCT
gs-3960	745	1	sulashvili	sulashvili	PROPN
gs-3960	745	2	n	n	CCONJ
gs-3960	745	3	,	,	PUNCT
gs-3960	745	4	nimangre	nimangre	PROPN
gs-3960	745	5	rr	rr	PROPN
gs-3960	745	6	.	.	PUNCT
gs-3960	746	1	manifestation	manifestation	NOUN
gs-3960	746	2	of	of	ADP
gs-3960	746	3	some	some	DET
gs-3960	746	4	aspects	aspect	NOUN
gs-3960	746	5	of	of	ADP
gs-3960	746	6	cardiovascular	cardiovascular	ADJ
gs-3960	746	7	diseases	disease	NOUN
gs-3960	746	8	,	,	PUNCT
gs-3960	746	9	implications	implication	NOUN
gs-3960	746	10	,	,	PUNCT
gs-3960	746	11	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-3960	746	12	strategies	strategy	NOUN
gs-3960	746	13	,	,	PUNCT
gs-3960	746	14	effects	effect	NOUN
gs-3960	746	15	,	,	PUNCT
gs-3960	746	16	impacts	impact	NOUN
gs-3960	746	17	and	and	CCONJ
gs-3960	746	18	potential	potential	ADJ
gs-3960	746	19	hazards	hazard	NOUN
gs-3960	746	20	in	in	ADP
gs-3960	746	21	general	general	ADJ
gs-3960	746	22	.	.	PUNCT
gs-3960	747	1	jr	jr	PROPN
gs-3960	748	1	[	[	X
gs-3960	748	2	internet	internet	NOUN
gs-3960	748	3	]	]	PUNCT
gs-3960	748	4	.	.	PUNCT
gs-3960	749	1	2025	2025	NUM
gs-3960	749	2	feb	feb	X
gs-3960	749	3	.	.	PROPN
gs-3960	749	4	7	7	NUM
gs-3960	749	5	[	[	X
gs-3960	749	6	cited	cite	VERB
gs-3960	749	7	2025	2025	NUM
gs-3960	749	8	jul	jul	PROPN
gs-3960	749	9	.	.	PUNCT
gs-3960	750	1	12];3(1):1	12];3(1):1	NUM
gs-3960	750	2	-	-	SYM
gs-3960	750	3	27	27	NUM
gs-3960	750	4	.	.	PUNCT
gs-3960	751	1	available	available	ADJ
gs-3960	751	2	from	from	ADP
gs-3960	751	3	:	:	PUNCT
gs-3960	751	4	https://journals.4science.ge/index.php/jr/article/view/3393	https://journals.4science.ge/index.php/jr/article/view/3393	PROPN
gs-3960	751	5	.	.	PUNCT
gs-3960	752	1	72	72	NUM
gs-3960	752	2	.	.	PUNCT
gs-3960	753	1	gorgaslidze	gorgaslidze	PROPN
gs-3960	753	2	,	,	PUNCT
gs-3960	753	3	nana	nana	PROPN
gs-3960	753	4	,	,	PUNCT
gs-3960	753	5	nodar	nodar	NOUN
gs-3960	753	6	sulashvili	sulashvili	NOUN
gs-3960	753	7	,	,	PUNCT
gs-3960	753	8	luiza	luiza	PROPN
gs-3960	753	9	gabunia	gabunia	PROPN
gs-3960	753	10	,	,	PUNCT
gs-3960	753	11	shafiga	shafiga	PROPN
gs-3960	753	12	topchiyeva	topchiyeva	PROPN
gs-3960	753	13	,	,	PUNCT
gs-3960	753	14	vira	vira	PROPN
gs-3960	753	15	kravchenko	kravchenko	PROPN
gs-3960	753	16	,	,	PUNCT
gs-3960	753	17	marina	marina	PROPN
gs-3960	753	18	giorgobiani	giorgobiani	PROPN
gs-3960	753	19	,	,	PUNCT
gs-3960	753	20	irina	irina	PROPN
gs-3960	753	21	aspects	aspect	NOUN
gs-3960	753	22	of	of	ADP
gs-3960	753	23	features	feature	NOUN
gs-3960	753	24	of	of	ADP
gs-3960	753	25	medicines	medicine	NOUN
gs-3960	753	26	turnover	turnover	NOUN
gs-3960	753	27	and	and	CCONJ
gs-3960	753	28	its	its	PRON
gs-3960	753	29	influence	influence	NOUN
gs-3960	753	30	on	on	ADP
gs-3960	753	31	environment	environment	NOUN
gs-3960	753	32	and	and	CCONJ
gs-3960	753	33	medical	medical	ADJ
gs-3960	753	34	-	-	PUNCT
gs-3960	753	35	ecological	ecological	ADJ
gs-3960	753	36	safety	safety	NOUN
gs-3960	753	37	challenges	challenge	NOUN
gs-3960	753	38	https://doi.org/10.52340/jecm.2024.04.35	https://doi.org/10.52340/jecm.2024.04.35	PROPN
gs-3960	753	39	.	.	PUNCT
gs-3960	754	1	georgian	georgian	NOUN
gs-3960	754	2	scientists/	scientists/	NUM
gs-3960	754	3	.	.	PUNCT
gs-3960	755	1	7	7	NUM
gs-3960	755	2	n	n	PRON
gs-3960	755	3	3	3	NUM
gs-3960	755	4	,	,	PUNCT
gs-3960	755	5	2025	2025	NUM
gs-3960	755	6	442	442	NUM
gs-3960	755	7	73	73	NUM
gs-3960	755	8	.	.	PUNCT
gs-3960	756	1	sulashvili	sulashvili	NOUN
gs-3960	756	2	,	,	PUNCT
gs-3960	756	3	nodar	nodar	ADV
gs-3960	756	4	,	,	PUNCT
gs-3960	756	5	margarita	margarita	PROPN
gs-3960	756	6	beglaryan	beglaryan	PROPN
gs-3960	756	7	,	,	PUNCT
gs-3960	756	8	nana	nana	PROPN
gs-3960	756	9	gorgaslidze	gorgaslidze	PROPN
gs-3960	756	10	,	,	PUNCT
gs-3960	756	11	seyran	seyran	PROPN
gs-3960	756	12	kocharyan	kocharyan	PROPN
gs-3960	756	13	,	,	PUNCT
gs-3960	756	14	naira	naira	PROPN
gs-3960	756	15	chichoyan	chichoyan	PROPN
gs-3960	756	16	,	,	PUNCT
gs-3960	756	17	luiza	luiza	PROPN
gs-3960	756	18	gabunia	gabunia	NOUN
gs-3960	756	19	,	,	PUNCT
gs-3960	756	20	opportunities	opportunity	NOUN
gs-3960	756	21	,	,	PUNCT
gs-3960	756	22	outlooks	outlook	NOUN
gs-3960	756	23	,	,	PUNCT
gs-3960	756	24	objections	objection	NOUN
gs-3960	756	25	,	,	PUNCT
gs-3960	756	26	appearances	appearance	NOUN
gs-3960	756	27	and	and	CCONJ
gs-3960	756	28	experimental	experimental	ADJ
gs-3960	756	29	and	and	CCONJ
gs-3960	756	30	clinical	clinical	ADJ
gs-3960	756	31	medicine	medicine	NOUN
gs-3960	756	32	georgia	georgia	PROPN
gs-3960	756	33	,	,	PUNCT
gs-3960	756	34	no	no	INTJ
gs-3960	756	35	.	.	NOUN
gs-3960	756	36	4	4	NUM
gs-3960	756	37	(	(	PUNCT
gs-3960	756	38	september):126	september):126	PROPN
gs-3960	756	39	-	-	PUNCT
gs-3960	756	40	29	29	NUM
gs-3960	756	41	.	.	PUNCT
gs-3960	757	1	https://doi.org/10.52340/jecm.2024.04.34	https://doi.org/10.52340/jecm.2024.04.34	NOUN
gs-3960	757	2	.	.	PUNCT
gs-3960	758	1	74	74	NUM
gs-3960	758	2	.	.	X
gs-3960	759	1	aphkhazava	aphkhazava	PROPN
gs-3960	759	2	,	,	PUNCT
gs-3960	759	3	david	david	PROPN
gs-3960	759	4	,	,	PUNCT
gs-3960	759	5	nodar	nodar	PROPN
gs-3960	759	6	sulashvili	sulashvili	NOUN
gs-3960	759	7	,	,	PUNCT
gs-3960	759	8	tamar	tamar	PROPN
gs-3960	759	9	tupinashvili	tupinashvili	NOUN
gs-3960	759	10	,	,	PUNCT
gs-3960	759	11	and	and	CCONJ
gs-3960	759	12	maia	maia	PROPN
gs-3960	759	13	https://doi.org/10.52340/spectri.2023.08.02.03	https://doi.org/10.52340/spectri.2023.08.02.03	PROPN
gs-3960	759	14	.	.	PROPN
gs-3960	760	1	75	75	NUM
gs-3960	760	2	.	.	PUNCT
gs-3960	761	1	katsyuba	katsyuba	ADJ
gs-3960	761	2	e	e	NOUN
gs-3960	761	3	,	,	PUNCT
gs-3960	761	4	romani	romani	PROPN
gs-3960	761	5	m	m	PROPN
gs-3960	761	6	,	,	PUNCT
gs-3960	761	7	hofer	hofer	PROPN
gs-3960	761	8	d	d	PROPN
gs-3960	761	9	,	,	PUNCT
gs-3960	761	10	auwerx	auwerx	PROPN
gs-3960	761	11	j.	j.	PROPN
gs-3960	761	12	nad	nad	PROPN
gs-3960	761	13	homeostasis	homeostasis	NOUN
gs-3960	761	14	in	in	ADP
gs-3960	761	15	health	health	NOUN
gs-3960	761	16	and	and	CCONJ
gs-3960	761	17	76	76	NUM
gs-3960	761	18	.	.	PUNCT
gs-3960	761	19	peredo	peredo	PROPN
gs-3960	761	20	ha	ha	INTJ
gs-3960	761	21	,	,	PUNCT
gs-3960	761	22	cardozo	cardozo	PROPN
gs-3960	761	23	j.	j.	PROPN
gs-3960	761	24	parkinson	parkinson	PROPN
gs-3960	761	25	's	's	PART
gs-3960	761	26	disease	disease	NOUN
gs-3960	761	27	and	and	CCONJ
gs-3960	761	28	mitochondrial	mitochondrial	ADJ
gs-3960	761	29	complex	complex	NOUN
gs-3960	761	30	i	i	X
gs-3960	761	31	:	:	PUNCT
gs-3960	761	32	a	a	DET
gs-3960	761	33	therapeutic	therapeutic	ADJ
gs-3960	761	34	target	target	NOUN
gs-3960	761	35	?	?	PUNCT
gs-3960	762	1	biol	biol	PROPN
gs-3960	762	2	res	re	NOUN
gs-3960	762	3	.	.	PUNCT
gs-3960	763	1	2014;47(1):28	2014;47(1):28	NUM
gs-3960	763	2	.	.	PUNCT
gs-3960	764	1	77	77	NUM
gs-3960	764	2	.	.	PUNCT
gs-3960	765	1	vaarmann	vaarmann	PROPN
gs-3960	765	2	a	a	PROPN
gs-3960	765	3	,	,	PUNCT
gs-3960	765	4	mandel	mandel	PROPN
gs-3960	765	5	m	m	PROPN
gs-3960	765	6	,	,	PUNCT
gs-3960	765	7	zeb	zeb	PROPN
gs-3960	765	8	a	a	NOUN
gs-3960	765	9	,	,	PUNCT
gs-3960	765	10	wareski	wareski	ADJ
gs-3960	765	11	p	p	X
gs-3960	765	12	,	,	PUNCT
gs-3960	765	13	liiv	liiv	PROPN
gs-3960	765	14	j	j	PROPN
gs-3960	765	15	,	,	PUNCT
gs-3960	765	16	kuum	kuum	PROPN
gs-3960	765	17	m	m	PROPN
gs-3960	765	18	,	,	PUNCT
gs-3960	765	19	et	et	PROPN
gs-3960	765	20	al	al	PROPN
gs-3960	765	21	.	.	PUNCT
gs-3960	766	1	mitochondrial	mitochondrial	ADJ
gs-3960	766	2	biogenesis	biogenesis	NOUN
gs-3960	766	3	is	be	AUX
gs-3960	766	4	required	require	VERB
gs-3960	766	5	for	for	ADP
gs-3960	766	6	axonal	axonal	ADJ
gs-3960	766	7	growth	growth	NOUN
gs-3960	766	8	.	.	PUNCT
gs-3960	767	1	development	development	NOUN
gs-3960	767	2	.	.	PUNCT
gs-3960	768	1	2016	2016	NUM
gs-3960	768	2	;	;	PUNCT
gs-3960	768	3	78	78	NUM
gs-3960	768	4	.	.	PUNCT
gs-3960	769	1	wang	wang	PROPN
gs-3960	769	2	x	x	PROPN
gs-3960	769	3	,	,	PUNCT
gs-3960	769	4	winter	winter	NOUN
gs-3960	769	5	d	d	PROPN
gs-3960	769	6	,	,	PUNCT
gs-3960	769	7	ashrafi	ashrafi	ADV
gs-3960	769	8	g	g	PROPN
gs-3960	769	9	,	,	PUNCT
gs-3960	769	10	schlehe	schlehe	PROPN
gs-3960	769	11	j	j	PROPN
gs-3960	769	12	,	,	PUNCT
gs-3960	769	13	wong	wong	PROPN
gs-3960	769	14	yl	yl	PROPN
gs-3960	769	15	,	,	PUNCT
gs-3960	769	16	selkoe	selkoe	PROPN
gs-3960	769	17	d	d	NOUN
gs-3960	769	18	,	,	PUNCT
gs-3960	769	19	et	et	PROPN
gs-3960	769	20	al	al	PROPN
gs-3960	769	21	.	.	PUNCT
gs-3960	769	22	pink1	pink1	NOUN
gs-3960	769	23	and	and	CCONJ
gs-3960	769	24	parkin	parkin	ADJ
gs-3960	769	25	target	target	NOUN
gs-3960	769	26	miro	miro	X
gs-3960	769	27	for	for	ADP
gs-3960	769	28	phosphorylation	phosphorylation	NOUN
gs-3960	769	29	and	and	CCONJ
gs-3960	769	30	degradation	degradation	NOUN
gs-3960	769	31	to	to	PART
gs-3960	769	32	arrest	arrest	VERB
gs-3960	769	33	mitochondrial	mitochondrial	ADJ
gs-3960	769	34	79	79	NUM
gs-3960	769	35	.	.	PUNCT
gs-3960	770	1	lautrup	lautrup	PROPN
gs-3960	770	2	s	s	PROPN
gs-3960	770	3	,	,	PUNCT
gs-3960	770	4	amjad	amjad	PROPN
gs-3960	770	5	hb	hb	PROPN
gs-3960	770	6	,	,	PUNCT
gs-3960	770	7	cenini	cenini	VERB
gs-3960	770	8	g	g	NOUN
gs-3960	770	9	,	,	PUNCT
gs-3960	770	10	fang	fang	X
gs-3960	770	11	ef	ef	PROPN
gs-3960	770	12	.	.	PUNCT
gs-3960	770	13	nad	nad	PROPN
gs-3960	770	14	in	in	ADP
gs-3960	770	15	brain	brain	NOUN
gs-3960	770	16	aging	aging	NOUN
gs-3960	770	17	and	and	CCONJ
gs-3960	770	18	neurodegeneration	neurodegeneration	NOUN
gs-3960	770	19	:	:	PUNCT
gs-3960	770	20	molecular	molecular	ADJ
gs-3960	770	21	mechanisms	mechanism	NOUN
gs-3960	770	22	and	and	CCONJ
gs-3960	770	23	therapeutic	therapeutic	ADJ
gs-3960	770	24	targets	target	NOUN
gs-3960	770	25	.	.	PUNCT
gs-3960	771	1	cell	cell	NOUN
gs-3960	771	2	mol	mol	ADP
gs-3960	771	3	life	life	PROPN
gs-3960	771	4	sci	sci	PROPN
gs-3960	771	5	.	.	PROPN
gs-3960	771	6	2023	2023	NUM
gs-3960	771	7	;	;	PUNCT
gs-3960	771	8	80(2):36	80(2):36	NUM
gs-3960	771	9	.	.	NOUN
gs-3960	771	10	80	80	NUM
gs-3960	771	11	.	.	PUNCT
gs-3960	772	1	franco	franco	NOUN
gs-3960	772	2	-	-	PUNCT
gs-3960	772	3	iborra	iborra	PROPN
gs-3960	772	4	s	s	PROPN
gs-3960	772	5	,	,	PUNCT
gs-3960	772	6	vila	vila	PROPN
gs-3960	772	7	m	m	PROPN
gs-3960	772	8	,	,	PUNCT
gs-3960	772	9	perier	peri	ADJ
gs-3960	772	10	c.	c.	PROPN
gs-3960	772	11	mitochondrial	mitochondrial	ADJ
gs-3960	772	12	quality	quality	NOUN
gs-3960	772	13	control	control	NOUN
gs-3960	772	14	in	in	ADP
gs-3960	772	15	front	front	ADJ
gs-3960	772	16	neurosci	neurosci	NOUN
gs-3960	772	17	.	.	PUNCT
gs-3960	772	18	2018	2018	NUM
gs-3960	772	19	;	;	PUNCT
gs-3960	772	20	12:342	12:342	NUM
gs-3960	772	21	.	.	PUNCT
gs-3960	773	1	81	81	NUM
gs-3960	773	2	.	.	PUNCT
gs-3960	774	1	campello	campello	PROPN
gs-3960	774	2	s	s	PROPN
gs-3960	774	3	,	,	PUNCT
gs-3960	774	4	scorrano	scorrano	PROPN
gs-3960	774	5	l.	l.	PROPN
gs-3960	774	6	mitochondrial	mitochondrial	ADJ
gs-3960	774	7	shape	shape	NOUN
gs-3960	774	8	changes	change	NOUN
gs-3960	774	9	:	:	PUNCT
gs-3960	774	10	orchestrating	orchestrate	VERB
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gs-3960	774	13	.	.	PUNCT
gs-3960	775	1	schapira	schapira	PROPN
gs-3960	775	2	ahv	ahv	PROPN
gs-3960	775	3	,	,	PUNCT
gs-3960	775	4	chaudhuri	chaudhuri	PROPN
gs-3960	775	5	kr	kr	PROPN
gs-3960	775	6	,	,	PUNCT
gs-3960	775	7	jenner	jenner	PROPN
gs-3960	775	8	p.	p.	PROPN
gs-3960	775	9	non	non	ADJ
gs-3960	775	10	-	-	ADJ
gs-3960	775	11	motor	motor	ADJ
gs-3960	775	12	features	feature	NOUN
gs-3960	775	13	of	of	ADP
gs-3960	775	14	parkinson	parkinson	NOUN
gs-3960	775	15	disease	disease	NOUN
gs-3960	775	16	.	.	PUNCT
gs-3960	776	1	nat	nat	PROPN
gs-3960	776	2	rev	rev	PROPN
gs-3960	776	3	neurosci	neurosci	PROPN
gs-3960	776	4	.	.	PUNCT
gs-3960	776	5	2017	2017	NUM
gs-3960	776	6	;	;	PUNCT
gs-3960	777	1	18(7):435	18(7):435	NUM
gs-3960	777	2	-	-	SYM
gs-3960	777	3	50	50	NUM
gs-3960	777	4	.	.	PUNCT
gs-3960	777	5	83	83	NUM
gs-3960	777	6	.	.	PUNCT
gs-3960	778	1	pickrell	pickrell	PROPN
gs-3960	778	2	am	am	PROPN
gs-3960	778	3	,	,	PUNCT
gs-3960	778	4	youle	youle	PROPN
gs-3960	778	5	rj	rj	PROPN
gs-3960	778	6	.	.	PUNCT
gs-3960	779	1	the	the	DET
gs-3960	779	2	roles	role	NOUN
gs-3960	779	3	of	of	ADP
gs-3960	779	4	pink1	pink1	NOUN
gs-3960	779	5	,	,	PUNCT
gs-3960	779	6	parkin	parkin	NOUN
gs-3960	779	7	,	,	PUNCT
gs-3960	779	8	and	and	CCONJ
gs-3960	779	9	mitochondrial	mitochondrial	ADJ
gs-3960	779	10	fidelity	fidelity	NOUN
gs-3960	779	11	in	in	ADP
gs-3960	779	12	parkinson	parkinson	NOUN
gs-3960	779	13	's	's	PART
gs-3960	779	14	disease	disease	NOUN
gs-3960	779	15	.	.	PUNCT
gs-3960	780	1	neuron	neuron	PROPN
gs-3960	780	2	.	.	PUNCT
gs-3960	781	1	2015	2015	NUM
gs-3960	781	2	;	;	PUNCT
gs-3960	781	3	85(2):257	85(2):257	NOUN
gs-3960	781	4	-	-	SYM
gs-3960	781	5	73	73	NUM
gs-3960	781	6	.	.	PUNCT
gs-3960	782	1	84	84	NUM
gs-3960	782	2	.	.	PUNCT
gs-3960	783	1	bose	bose	PROPN
gs-3960	783	2	a	a	DET
gs-3960	783	3	,	,	PUNCT
gs-3960	783	4	beal	beal	NOUN
gs-3960	783	5	mf	mf	NOUN
gs-3960	783	6	.	.	PROPN
gs-3960	783	7	mitochondrial	mitochondrial	ADJ
gs-3960	783	8	dysfunction	dysfunction	NOUN
gs-3960	783	9	in	in	ADP
gs-3960	783	10	parkinson	parkinson	NOUN
gs-3960	783	11	's	's	PART
gs-3960	783	12	disease	disease	NOUN
gs-3960	783	13	.	.	PUNCT
gs-3960	784	1	j	j	PROPN
gs-3960	784	2	neurochem	neurochem	PROPN
gs-3960	784	3	.	.	PUNCT
gs-3960	785	1	2016;139	2016;139	NUM
gs-3960	785	2	suppl	suppl	ADJ
gs-3960	785	3	1:216	1:216	NUM
gs-3960	785	4	-	-	SYM
gs-3960	785	5	31	31	NUM
gs-3960	785	6	.	.	PUNCT
gs-3960	785	7	85	85	NUM
gs-3960	785	8	.	.	PUNCT
gs-3960	785	9	titova	titova	PROPN
gs-3960	785	10	n	n	CCONJ
gs-3960	785	11	,	,	PUNCT
gs-3960	785	12	chaudhuri	chaudhuri	PROPN
gs-3960	785	13	kr	kr	PROPN
gs-3960	785	14	.	.	PROPN
gs-3960	786	1	personalized	personalize	VERB
gs-3960	786	2	medicine	medicine	NOUN
gs-3960	786	3	in	in	ADP
gs-3960	786	4	parkinson	parkinson	NOUN
gs-3960	786	5	's	's	PART
gs-3960	786	6	disease	disease	NOUN
gs-3960	786	7	:	:	PUNCT
gs-3960	786	8	time	time	NOUN
gs-3960	786	9	to	to	PART
gs-3960	786	10	be	be	AUX
gs-3960	786	11	precise	precise	ADJ
gs-3960	786	12	.	.	PUNCT
gs-3960	787	1	mov	mov	NOUN
gs-3960	787	2	disord	disord	NOUN
gs-3960	787	3	.	.	PUNCT
gs-3960	788	1	2017	2017	NUM
gs-3960	788	2	;	;	PUNCT
gs-3960	788	3	32(8):1147	32(8):1147	NUM
gs-3960	788	4	-	-	SYM
gs-3960	788	5	54	54	NUM
gs-3960	788	6	.	.	PUNCT