id	sid	tid	token	lemma	pos
gs-4060	1	1	georgian	georgian	PROPN
gs-4060	1	2	scientists/	scientists/	NUM
gs-4060	1	3	.	.	PUNCT
gs-4060	2	1	7	7	NUM
gs-4060	2	2	n	n	PRON
gs-4060	2	3	3	3	NUM
gs-4060	2	4	,	,	PUNCT
gs-4060	2	5	2025	2025	NUM
gs-4060	2	6	570	570	NUM
gs-4060	2	7	georgian	georgian	PROPN
gs-4060	2	8	scientists	scientist	NOUN
gs-4060	2	9	vol	vol	NOUN
gs-4060	2	10	.	.	PUNCT
gs-4060	2	11	7	7	NUM
gs-4060	2	12	issue	issue	NOUN
gs-4060	2	13	3	3	NUM
gs-4060	2	14	,	,	PUNCT
gs-4060	2	15	2025	2025	NUM
gs-4060	2	16	https://doi.org/10.52340/gs.2025.07.03.31	https://doi.org/10.52340/gs.2025.07.03.31	PROPN
gs-4060	2	17	the	the	DET
gs-4060	2	18	manifestation	manifestation	NOUN
gs-4060	2	19	of	of	ADP
gs-4060	2	20	scientific	scientific	ADJ
gs-4060	2	21	aspects	aspect	NOUN
gs-4060	2	22	of	of	ADP
gs-4060	2	23	classification	classification	NOUN
gs-4060	2	24	,	,	PUNCT
gs-4060	2	25	clinical	clinical	ADJ
gs-4060	2	26	use	use	NOUN
gs-4060	2	27	,	,	PUNCT
gs-4060	2	28	features	feature	NOUN
gs-4060	2	29	,	,	PUNCT
gs-4060	2	30	mechanism	mechanism	NOUN
gs-4060	2	31	of	of	ADP
gs-4060	2	32	action	action	NOUN
gs-4060	2	33	,	,	PUNCT
gs-4060	2	34	pharmacology	pharmacology	NOUN
gs-4060	2	35	,	,	PUNCT
gs-4060	2	36	effects	effect	NOUN
gs-4060	2	37	and	and	CCONJ
gs-4060	2	38	toxicities	toxicity	NOUN
gs-4060	2	39	of	of	ADP
gs-4060	2	40	new	new	ADJ
gs-4060	2	41	anticancer	anticancer	NOUN
gs-4060	2	42	drugs	drug	NOUN
gs-4060	2	43	in	in	ADP
gs-4060	2	44	general	general	ADJ
gs-4060	2	45	nodar	nodar	PROPN
gs-4060	2	46	sulashvili1	sulashvili1	PROPN
gs-4060	2	47	,	,	PUNCT
gs-4060	2	48	udgam	udgam	PROPN
gs-4060	2	49	yaduvanshi2	yaduvanshi2	NOUN
gs-4060	2	50	,	,	PUNCT
gs-4060	2	51	nirjhar	nirjhar	VERB
gs-4060	2	52	yaduvanshi3	yaduvanshi3	PROPN
gs-4060	2	53	,	,	PUNCT
gs-4060	2	54	mohini	mohini	PROPN
gs-4060	2	55	yadav4	yadav4	PROPN
gs-4060	2	56	,	,	PUNCT
gs-4060	2	57	elene	elene	NOUN
gs-4060	2	58	abzianidze5	abzianidze5	NOUN
gs-4060	2	59	,	,	PUNCT
gs-4060	2	60	naira	naira	PROPN
gs-4060	2	61	chichoyan6	chichoyan6	NOUN
gs-4060	2	62	,	,	PUNCT
gs-4060	2	63	luiza	luiza	PROPN
gs-4060	2	64	gabunia7	gabunia7	PROPN
gs-4060	2	65	,	,	PUNCT
gs-4060	2	66	nana	nana	PROPN
gs-4060	2	67	gorgaslidze8	gorgaslidze8	PROPN
gs-4060	2	68	,	,	PUNCT
gs-4060	2	69	nato	nato	PROPN
gs-4060	2	70	alavidze9	alavidze9	PROPN
gs-4060	2	71	,	,	PUNCT
gs-4060	2	72	nino	nino	PROPN
gs-4060	2	73	abuladze10	abuladze10	PROPN
gs-4060	2	74	,	,	PUNCT
gs-4060	2	75	ketevani	ketevani	PROPN
gs-4060	2	76	gabunia11	gabunia11	PROPN
gs-4060	2	77	,	,	PUNCT
gs-4060	2	78	natia	natia	PROPN
gs-4060	2	79	kvizhinadze12	kvizhinadze12	PROPN
gs-4060	2	80	,	,	PUNCT
gs-4060	2	81	igor	igor	PROPN
gs-4060	2	82	seniuk13	seniuk13	PROPN
gs-4060	2	83	,	,	PUNCT
gs-4060	2	84	marika	marika	PROPN
gs-4060	2	85	sulashvili14	sulashvili14	PROPN
gs-4060	2	86	,	,	PUNCT
gs-4060	2	87	tamar	tamar	PROPN
gs-4060	2	88	okropiridze15	okropiridze15	PROPN
gs-4060	2	89	,	,	PUNCT
gs-4060	2	90	lela	lela	PROPN
gs-4060	2	91	grigolia16	grigolia16	PROPN
gs-4060	2	92	,	,	PUNCT
gs-4060	2	93	kakhaber	kakhaber	PROPN
gs-4060	2	94	robakidze17	robakidze17	PROPN
gs-4060	2	95	,	,	PUNCT
gs-4060	2	96	marina	marina	PROPN
gs-4060	2	97	giorgobiani18	giorgobiani18	PROPN
gs-4060	2	98	,	,	PUNCT
gs-4060	2	99	irine	irine	NOUN
gs-4060	2	100	zarnadze19	zarnadze19	NOUN
gs-4060	2	101	,	,	PUNCT
gs-4060	2	102	shalva	shalva	PROPN
gs-4060	2	103	(	(	PUNCT
gs-4060	2	104	davit	davit	NOUN
gs-4060	2	105	)	)	PUNCT
gs-4060	2	106	zarnadze20	zarnadze20	PROPN
gs-4060	2	107	1	1	NUM
gs-4060	2	108	.	.	X
gs-4060	2	109	md	md	PROPN
gs-4060	2	110	,	,	PUNCT
gs-4060	2	111	phd	phd	NOUN
gs-4060	2	112	,	,	PUNCT
gs-4060	2	113	doctor	doctor	NOUN
gs-4060	2	114	of	of	ADP
gs-4060	2	115	pharmaceutical	pharmaceutical	ADJ
gs-4060	2	116	and	and	CCONJ
gs-4060	2	117	pharmacological	pharmacological	ADJ
gs-4060	2	118	sciences	science	NOUN
gs-4060	2	119	in	in	ADP
gs-4060	2	120	medicine	medicine	NOUN
gs-4060	2	121	,	,	PUNCT
gs-4060	2	122	invited	invite	VERB
gs-4060	2	123	lecturer	lecturer	NOUN
gs-4060	2	124	(	(	PUNCT
gs-4060	2	125	invited	invite	VERB
gs-4060	2	126	professor	professor	NOUN
gs-4060	2	127	)	)	PUNCT
gs-4060	2	128	of	of	ADP
gs-4060	2	129	scientific	scientific	ADJ
gs-4060	2	130	research	research	NOUN
gs-4060	2	131	-	-	PUNCT
gs-4060	2	132	skills	skill	NOUN
gs-4060	2	133	center	center	NOUN
gs-4060	2	134	at	at	ADP
gs-4060	2	135	tbilisi	tbilisi	PROPN
gs-4060	2	136	state	state	PROPN
gs-4060	2	137	medical	medical	PROPN
gs-4060	2	138	university	university	PROPN
gs-4060	2	139	;	;	PUNCT
gs-4060	2	140	professor	professor	NOUN
gs-4060	2	141	of	of	ADP
gs-4060	2	142	medical	medical	ADJ
gs-4060	2	143	and	and	CCONJ
gs-4060	2	144	clinical	clinical	ADJ
gs-4060	2	145	pharmacology	pharmacology	NOUN
gs-4060	2	146	of	of	ADP
gs-4060	2	147	international	international	ADJ
gs-4060	2	148	school	school	NOUN
gs-4060	2	149	of	of	ADP
gs-4060	2	150	medicine	medicine	NOUN
gs-4060	2	151	at	at	ADP
gs-4060	2	152	alte	alte	PROPN
gs-4060	2	153	university	university	PROPN
gs-4060	2	154	;	;	PUNCT
gs-4060	2	155	professor	professor	NOUN
gs-4060	2	156	of	of	ADP
gs-4060	2	157	pharmacology	pharmacology	NOUN
gs-4060	2	158	of	of	ADP
gs-4060	2	159	faculty	faculty	NOUN
gs-4060	2	160	of	of	ADP
gs-4060	2	161	medicine	medicine	NOUN
gs-4060	2	162	at	at	ADP
gs-4060	2	163	georgian	georgian	PROPN
gs-4060	2	164	national	national	PROPN
gs-4060	2	165	university	university	PROPN
gs-4060	2	166	seu	seu	PROPN
gs-4060	2	167	;	;	PUNCT
gs-4060	2	168	tbilisi	tbilisi	PROPN
gs-4060	2	169	,	,	PUNCT
gs-4060	2	170	georgia	georgia	PROPN
gs-4060	2	171	;	;	PUNCT
gs-4060	2	172	orcid	orcid	PROPN
gs-4060	2	173	https://orcid.org/0000-0002-9005-8577	https://orcid.org/0000-0002-9005-8577	PROPN
gs-4060	2	174	;	;	PUNCT
gs-4060	2	175	e	e	X
gs-4060	2	176	-	-	NOUN
gs-4060	2	177	mail	mail	NOUN
gs-4060	2	178	:	:	PUNCT
gs-4060	2	179	n.sulashvili@ug.edu.ge	n.sulashvili@ug.edu.ge	PROPN
gs-4060	2	180	2	2	NUM
gs-4060	2	181	.	.	PUNCT
gs-4060	2	182	md	md	PROPN
gs-4060	2	183	student	student	NOUN
gs-4060	2	184	of	of	ADP
gs-4060	2	185	medical	medical	ADJ
gs-4060	2	186	doctor	doctor	NOUN
gs-4060	2	187	degree	degree	NOUN
gs-4060	2	188	program	program	NOUN
gs-4060	2	189	of	of	ADP
gs-4060	2	190	international	international	ADJ
gs-4060	2	191	school	school	NOUN
gs-4060	2	192	of	of	ADP
gs-4060	2	193	medicine	medicine	NOUN
gs-4060	2	194	at	at	ADP
gs-4060	2	195	alte	alte	PROPN
gs-4060	2	196	university	university	PROPN
gs-4060	2	197	;	;	PUNCT
gs-4060	2	198	tbilisi	tbilisi	PROPN
gs-4060	2	199	,	,	PUNCT
gs-4060	2	200	georgia	georgia	PROPN
gs-4060	2	201	;	;	PUNCT
gs-4060	2	202	3	3	X
gs-4060	2	203	.	.	X
gs-4060	2	204	md	md	PROPN
gs-4060	2	205	student	student	NOUN
gs-4060	2	206	of	of	ADP
gs-4060	2	207	medical	medical	ADJ
gs-4060	2	208	doctor	doctor	NOUN
gs-4060	2	209	degree	degree	NOUN
gs-4060	2	210	program	program	NOUN
gs-4060	2	211	of	of	ADP
gs-4060	2	212	international	international	ADJ
gs-4060	2	213	school	school	NOUN
gs-4060	2	214	of	of	ADP
gs-4060	2	215	medicine	medicine	NOUN
gs-4060	2	216	at	at	ADP
gs-4060	2	217	alte	alte	PROPN
gs-4060	2	218	university	university	PROPN
gs-4060	2	219	;	;	PUNCT
gs-4060	2	220	tbilisi	tbilisi	PROPN
gs-4060	2	221	,	,	PUNCT
gs-4060	2	222	georgia	georgia	PROPN
gs-4060	2	223	;	;	PUNCT
gs-4060	2	224	4	4	NUM
gs-4060	2	225	.	.	X
gs-4060	2	226	md	md	PROPN
gs-4060	2	227	student	student	NOUN
gs-4060	2	228	of	of	ADP
gs-4060	2	229	medical	medical	ADJ
gs-4060	2	230	doctor	doctor	NOUN
gs-4060	2	231	degree	degree	NOUN
gs-4060	2	232	program	program	NOUN
gs-4060	2	233	of	of	ADP
gs-4060	2	234	international	international	ADJ
gs-4060	2	235	school	school	NOUN
gs-4060	2	236	of	of	ADP
gs-4060	2	237	medicine	medicine	NOUN
gs-4060	2	238	at	at	ADP
gs-4060	2	239	alte	alte	PROPN
gs-4060	2	240	university	university	PROPN
gs-4060	2	241	;	;	PUNCT
gs-4060	2	242	tbilisi	tbilisi	PROPN
gs-4060	2	243	,	,	PUNCT
gs-4060	2	244	georgia	georgia	PROPN
gs-4060	2	245	;	;	PUNCT
gs-4060	2	246	5	5	NUM
gs-4060	2	247	.	.	X
gs-4060	2	248	phd	phd	NOUN
gs-4060	2	249	,	,	PUNCT
gs-4060	2	250	doctor	doctor	NOUN
gs-4060	2	251	of	of	ADP
gs-4060	2	252	biological	biological	ADJ
gs-4060	2	253	sciences	science	NOUN
gs-4060	2	254	,	,	PUNCT
gs-4060	2	255	academician	academician	NOUN
gs-4060	2	256	,	,	PUNCT
gs-4060	2	257	emeritus	emeritus	ADJ
gs-4060	2	258	professor	professor	NOUN
gs-4060	2	259	of	of	ADP
gs-4060	2	260	tbilisi	tbilisi	PROPN
gs-4060	2	261	state	state	PROPN
gs-4060	2	262	medical	medical	PROPN
gs-4060	2	263	university	university	PROPN
gs-4060	2	264	,	,	PUNCT
gs-4060	2	265	department	department	NOUN
gs-4060	2	266	of	of	ADP
gs-4060	2	267	molecular	molecular	ADJ
gs-4060	2	268	and	and	CCONJ
gs-4060	2	269	medical	medical	ADJ
gs-4060	2	270	genetics	genetic	NOUN
gs-4060	2	271	;	;	PUNCT
gs-4060	2	272	https://orcid.org/0000-0002-11407688	https://orcid.org/0000-0002-11407688	PROPN
gs-4060	2	273	;	;	PUNCT
gs-4060	2	274	tbilisi	tbilisi	PROPN
gs-4060	2	275	,	,	PUNCT
gs-4060	2	276	georgia	georgia	PROPN
gs-4060	2	277	.	.	PUNCT
gs-4060	3	1	6	6	NUM
gs-4060	3	2	.	.	X
gs-4060	3	3	md	md	PROPN
gs-4060	3	4	,	,	PUNCT
gs-4060	3	5	phd	phd	NOUN
gs-4060	3	6	,	,	PUNCT
gs-4060	3	7	doctor	doctor	NOUN
gs-4060	3	8	of	of	ADP
gs-4060	3	9	pharmaceutical	pharmaceutical	NOUN
gs-4060	3	10	sciences	science	NOUN
gs-4060	3	11	,	,	PUNCT
gs-4060	3	12	professor	professor	NOUN
gs-4060	3	13	of	of	ADP
gs-4060	3	14	yerevan	yerevan	PROPN
gs-4060	3	15	state	state	PROPN
gs-4060	3	16	medical	medical	PROPN
gs-4060	3	17	university	university	PROPN
gs-4060	3	18	after	after	ADP
gs-4060	3	19	mkhitar	mkhitar	NOUN
gs-4060	3	20	heratsi	heratsi	PROPN
gs-4060	3	21	,	,	PUNCT
gs-4060	3	22	head	head	NOUN
gs-4060	3	23	of	of	ADP
gs-4060	3	24	the	the	DET
gs-4060	3	25	department	department	NOUN
gs-4060	3	26	of	of	ADP
gs-4060	3	27	pharmacognosy	pharmacognosy	NOUN
gs-4060	3	28	,	,	PUNCT
gs-4060	3	29	yerevan	yerevan	PROPN
gs-4060	3	30	,	,	PUNCT
gs-4060	3	31	armenia	armenia	PROPN
gs-4060	3	32	.	.	PUNCT
gs-4060	4	1	https://orcid.org/0000-0003-3905-3372	https://orcid.org/0000-0003-3905-3372	PROPN
gs-4060	4	2	7	7	NUM
gs-4060	4	3	.	.	PUNCT
gs-4060	4	4	md	md	PROPN
gs-4060	4	5	,	,	PUNCT
gs-4060	4	6	phd	phd	NOUN
gs-4060	4	7	,	,	PUNCT
gs-4060	4	8	doctor	doctor	NOUN
gs-4060	4	9	of	of	ADP
gs-4060	4	10	medical	medical	ADJ
gs-4060	4	11	sciences	sciences	PROPN
gs-4060	4	12	,	,	PUNCT
gs-4060	4	13	professor	professor	NOUN
gs-4060	4	14	,	,	PUNCT
gs-4060	4	15	director	director	NOUN
gs-4060	4	16	of	of	ADP
gs-4060	4	17	the	the	DET
gs-4060	4	18	scientific	scientific	ADJ
gs-4060	4	19	research	research	NOUN
gs-4060	4	20	-	-	PUNCT
gs-4060	4	21	skills	skill	NOUN
gs-4060	4	22	center	center	NOUN
gs-4060	4	23	at	at	ADP
gs-4060	4	24	tbilisi	tbilisi	PROPN
gs-4060	4	25	state	state	PROPN
gs-4060	4	26	medical	medical	PROPN
gs-4060	4	27	university	university	PROPN
gs-4060	4	28	,	,	PUNCT
gs-4060	4	29	professor	professor	NOUN
gs-4060	4	30	,	,	PUNCT
gs-4060	4	31	head	head	NOUN
gs-4060	4	32	of	of	ADP
gs-4060	4	33	the	the	DET
gs-4060	4	34	department	department	PROPN
gs-4060	4	35	of	of	ADP
gs-4060	4	36	medical	medical	ADJ
gs-4060	4	37	and	and	CCONJ
gs-4060	4	38	clinical	clinical	ADJ
gs-4060	4	39	pharmacology	pharmacology	NOUN
gs-4060	4	40	at	at	ADP
gs-4060	4	41	tbilisi	tbilisi	PROPN
gs-4060	4	42	state	state	PROPN
gs-4060	4	43	medical	medical	PROPN
gs-4060	4	44	university	university	PROPN
gs-4060	4	45	,	,	PUNCT
gs-4060	4	46	clinical	clinical	ADJ
gs-4060	4	47	pharmacologist	pharmacologist	NOUN
gs-4060	4	48	of	of	ADP
gs-4060	4	49	the	the	DET
gs-4060	4	50	first	first	ADJ
gs-4060	4	51	university	university	NOUN
gs-4060	4	52	clinic	clinic	NOUN
gs-4060	4	53	of	of	ADP
gs-4060	4	54	tsmu	tsmu	PROPN
gs-4060	4	55	,	,	PUNCT
gs-4060	4	56	tbilisi	tbilisi	PROPN
gs-4060	4	57	,	,	PUNCT
gs-4060	4	58	georgia	georgia	PROPN
gs-4060	4	59	https://orcid.org/0000-0003-0856-2684	https://orcid.org/0000-0003-0856-2684	PROPN
gs-4060	4	60	8	8	NUM
gs-4060	4	61	.	.	PUNCT
gs-4060	5	1	md	md	PROPN
gs-4060	5	2	,	,	PUNCT
gs-4060	5	3	phd	phd	NOUN
gs-4060	5	4	,	,	PUNCT
gs-4060	5	5	doctor	doctor	NOUN
gs-4060	5	6	of	of	ADP
gs-4060	5	7	pharmaceutical	pharmaceutical	NOUN
gs-4060	5	8	sciences	science	NOUN
gs-4060	5	9	,	,	PUNCT
gs-4060	5	10	academician	academician	NOUN
gs-4060	5	11	,	,	PUNCT
gs-4060	5	12	professor	professor	NOUN
gs-4060	5	13	of	of	ADP
gs-4060	5	14	tbilisi	tbilisi	PROPN
gs-4060	5	15	state	state	PROPN
gs-4060	5	16	medical	medical	PROPN
gs-4060	5	17	university	university	PROPN
gs-4060	5	18	,	,	PUNCT
gs-4060	5	19	head	head	NOUN
gs-4060	5	20	of	of	ADP
gs-4060	5	21	the	the	DET
gs-4060	5	22	department	department	NOUN
gs-4060	5	23	of	of	ADP
gs-4060	5	24	social	social	ADJ
gs-4060	5	25	and	and	CCONJ
gs-4060	5	26	clinical	clinical	ADJ
gs-4060	5	27	pharmacy	pharmacy	NOUN
gs-4060	5	28	,	,	PUNCT
gs-4060	5	29	tbilisi	tbilisi	PROPN
gs-4060	5	30	,	,	PUNCT
gs-4060	5	31	georgia	georgia	PROPN
gs-4060	5	32	.	.	PUNCT
gs-4060	6	1	https://orcid.org/0000-0002-4563-5224	https://orcid.org/0000-0002-4563-5224	PROPN
gs-4060	6	2	9	9	NUM
gs-4060	6	3	.	.	X
gs-4060	7	1	md	md	PROPN
gs-4060	7	2	,	,	PUNCT
gs-4060	7	3	phd	phd	NOUN
gs-4060	7	4	,	,	PUNCT
gs-4060	7	5	doctor	doctor	NOUN
gs-4060	7	6	of	of	ADP
gs-4060	7	7	pharmaceutical	pharmaceutical	NOUN
gs-4060	7	8	sciences	science	NOUN
gs-4060	7	9	,	,	PUNCT
gs-4060	7	10	professor	professor	NOUN
gs-4060	7	11	of	of	ADP
gs-4060	7	12	akaki	akaki	PROPN
gs-4060	7	13	tsereteli	tsereteli	PROPN
gs-4060	7	14	state	state	PROPN
gs-4060	7	15	university	university	PROPN
gs-4060	7	16	,	,	PUNCT
gs-4060	7	17	faculty	faculty	NOUN
gs-4060	7	18	of	of	ADP
gs-4060	7	19	medicine	medicine	NOUN
gs-4060	7	20	,	,	PUNCT
gs-4060	7	21	department	department	NOUN
gs-4060	7	22	of	of	ADP
gs-4060	7	23	pharmacy	pharmacy	NOUN
gs-4060	7	24	,	,	PUNCT
gs-4060	7	25	kutaisi	kutaisi	PROPN
gs-4060	7	26	,	,	PUNCT
gs-4060	7	27	georgia	georgia	PROPN
gs-4060	7	28	.	.	PUNCT
gs-4060	8	1	professor	professor	PROPN
gs-4060	8	2	,	,	PUNCT
gs-4060	8	3	dean	dean	PROPN
gs-4060	8	4	faculty	faculty	NOUN
gs-4060	8	5	of	of	ADP
gs-4060	8	6	medicine	medicine	NOUN
gs-4060	8	7	at	at	ADP
gs-4060	8	8	east	east	PROPN
gs-4060	8	9	european	european	PROPN
gs-4060	8	10	university	university	PROPN
gs-4060	8	11	,	,	PUNCT
gs-4060	8	12	tbilisi	tbilisi	PROPN
gs-4060	8	13	,	,	PUNCT
gs-4060	8	14	georgia	georgia	PROPN
gs-4060	8	15	.	.	PUNCT
gs-4060	9	1	https://orcid.org/0000-0001-6695-5924	https://orcid.org/0000-0001-6695-5924	NOUN
gs-4060	9	2	georgian	georgian	NOUN
gs-4060	9	3	scientists/	scientists/	NUM
gs-4060	9	4	.	.	PUNCT
gs-4060	10	1	7	7	NUM
gs-4060	10	2	n	n	PRON
gs-4060	10	3	3	3	NUM
gs-4060	10	4	,	,	PUNCT
gs-4060	10	5	2025	2025	NUM
gs-4060	10	6	571	571	NUM
gs-4060	10	7	10	10	NUM
gs-4060	10	8	.	.	PUNCT
gs-4060	11	1	md	md	PROPN
gs-4060	11	2	,	,	PUNCT
gs-4060	11	3	phd	phd	NOUN
gs-4060	11	4	,	,	PUNCT
gs-4060	11	5	doctor	doctor	NOUN
gs-4060	11	6	of	of	ADP
gs-4060	11	7	pharmaceutical	pharmaceutical	NOUN
gs-4060	11	8	sciences	science	NOUN
gs-4060	11	9	,	,	PUNCT
gs-4060	11	10	professor	professor	NOUN
gs-4060	11	11	of	of	ADP
gs-4060	11	12	akaki	akaki	PROPN
gs-4060	11	13	tsereteli	tsereteli	PROPN
gs-4060	11	14	state	state	PROPN
gs-4060	11	15	university	university	PROPN
gs-4060	11	16	,	,	PUNCT
gs-4060	11	17	faculty	faculty	NOUN
gs-4060	11	18	of	of	ADP
gs-4060	11	19	medicine	medicine	NOUN
gs-4060	11	20	,	,	PUNCT
gs-4060	11	21	department	department	NOUN
gs-4060	11	22	of	of	ADP
gs-4060	11	23	pharmacy	pharmacy	NOUN
gs-4060	11	24	,	,	PUNCT
gs-4060	11	25	kutaisi	kutaisi	PROPN
gs-4060	11	26	,	,	PUNCT
gs-4060	11	27	georgia	georgia	PROPN
gs-4060	11	28	.	.	PUNCT
gs-4060	11	29	https://orcid.org/0000-0003-21897470	https://orcid.org/0000-0003-21897470	PROPN
gs-4060	11	30	11	11	NUM
gs-4060	11	31	.	.	PUNCT
gs-4060	12	1	md	md	PROPN
gs-4060	12	2	,	,	PUNCT
gs-4060	12	3	phd	phd	NOUN
gs-4060	12	4	,	,	PUNCT
gs-4060	12	5	doctor	doctor	NOUN
gs-4060	12	6	of	of	ADP
gs-4060	12	7	pharmaceutical	pharmaceutical	NOUN
gs-4060	12	8	sciences	science	NOUN
gs-4060	12	9	,	,	PUNCT
gs-4060	12	10	professor	professor	NOUN
gs-4060	12	11	of	of	ADP
gs-4060	12	12	akaki	akaki	PROPN
gs-4060	12	13	tsereteli	tsereteli	PROPN
gs-4060	12	14	state	state	PROPN
gs-4060	12	15	university	university	PROPN
gs-4060	12	16	,	,	PUNCT
gs-4060	12	17	faculty	faculty	NOUN
gs-4060	12	18	of	of	ADP
gs-4060	12	19	medicine	medicine	NOUN
gs-4060	12	20	,	,	PUNCT
gs-4060	12	21	department	department	NOUN
gs-4060	12	22	of	of	ADP
gs-4060	12	23	pharmacy	pharmacy	NOUN
gs-4060	12	24	,	,	PUNCT
gs-4060	12	25	kutaisi	kutaisi	PROPN
gs-4060	12	26	,	,	PUNCT
gs-4060	12	27	georgia	georgia	PROPN
gs-4060	12	28	.	.	PUNCT
gs-4060	13	1	https://orcid.org/0000-0002-58576593	https://orcid.org/0000-0002-58576593	PROPN
gs-4060	13	2	;	;	PUNCT
gs-4060	14	1	12	12	NUM
gs-4060	14	2	.	.	PUNCT
gs-4060	15	1	md	md	PROPN
gs-4060	15	2	,	,	PUNCT
gs-4060	15	3	phd	phd	NOUN
gs-4060	15	4	,	,	PUNCT
gs-4060	15	5	doctor	doctor	NOUN
gs-4060	15	6	of	of	ADP
gs-4060	15	7	pharmaceutical	pharmaceutical	NOUN
gs-4060	15	8	sciences	science	NOUN
gs-4060	15	9	,	,	PUNCT
gs-4060	15	10	professor	professor	NOUN
gs-4060	15	11	of	of	ADP
gs-4060	15	12	tbilisi	tbilisi	PROPN
gs-4060	15	13	state	state	PROPN
gs-4060	15	14	medical	medical	PROPN
gs-4060	15	15	university	university	PROPN
gs-4060	15	16	,	,	PUNCT
gs-4060	15	17	department	department	NOUN
gs-4060	15	18	of	of	ADP
gs-4060	15	19	social	social	ADJ
gs-4060	15	20	and	and	CCONJ
gs-4060	15	21	clinical	clinical	ADJ
gs-4060	15	22	pharmacy	pharmacy	NOUN
gs-4060	15	23	;	;	PUNCT
gs-4060	15	24	tbilisi	tbilisi	PROPN
gs-4060	15	25	,	,	PUNCT
gs-4060	15	26	georgia	georgia	PROPN
gs-4060	15	27	.	.	PUNCT
gs-4060	16	1	13	13	NUM
gs-4060	16	2	.	.	X
gs-4060	16	3	phd	phd	NOUN
gs-4060	16	4	,	,	PUNCT
gs-4060	16	5	doctor	doctor	NOUN
gs-4060	16	6	of	of	ADP
gs-4060	16	7	pharmaceutical	pharmaceutical	NOUN
gs-4060	16	8	sciences	science	NOUN
gs-4060	16	9	,	,	PUNCT
gs-4060	16	10	dean	dean	NOUN
gs-4060	16	11	of	of	ADP
gs-4060	16	12	faculty	faculty	NOUN
gs-4060	16	13	of	of	ADP
gs-4060	16	14	pharmacy	pharmacy	NOUN
gs-4060	16	15	at	at	ADP
gs-4060	16	16	national	national	PROPN
gs-4060	16	17	university	university	PROPN
gs-4060	16	18	of	of	ADP
gs-4060	16	19	pharmacy	pharmacy	NOUN
gs-4060	16	20	of	of	ADP
gs-4060	16	21	ukraine	ukraine	NOUN
gs-4060	16	22	,	,	PUNCT
gs-4060	16	23	associate	associate	ADJ
gs-4060	16	24	professor	professor	NOUN
gs-4060	16	25	of	of	ADP
gs-4060	16	26	biological	biological	ADJ
gs-4060	16	27	chemistry	chemistry	NOUN
gs-4060	16	28	department	department	NOUN
gs-4060	16	29	at	at	ADP
gs-4060	16	30	national	national	PROPN
gs-4060	16	31	university	university	PROPN
gs-4060	16	32	of	of	ADP
gs-4060	16	33	pharmacy	pharmacy	NOUN
gs-4060	16	34	of	of	ADP
gs-4060	16	35	ukraine	ukraine	NOUN
gs-4060	16	36	,	,	PUNCT
gs-4060	16	37	https://orcid.org/0000-0003-3819-733	https://orcid.org/0000-0003-3819-733	PROPN
gs-4060	16	38	;	;	PUNCT
gs-4060	16	39	kharkiv	kharkiv	PROPN
gs-4060	16	40	,	,	PUNCT
gs-4060	16	41	ukraine	ukraine	NOUN
gs-4060	16	42	.	.	PUNCT
gs-4060	17	1	14	14	NUM
gs-4060	17	2	.	.	X
gs-4060	18	1	md	md	PROPN
gs-4060	18	2	,	,	PUNCT
gs-4060	18	3	doctor	doctor	NOUN
gs-4060	18	4	of	of	ADP
gs-4060	18	5	family	family	NOUN
gs-4060	18	6	medicine	medicine	NOUN
gs-4060	18	7	,	,	PUNCT
gs-4060	18	8	invited	invite	VERB
gs-4060	18	9	lecturer	lecturer	NOUN
gs-4060	18	10	of	of	ADP
gs-4060	18	11	tbilisi	tbilisi	PROPN
gs-4060	18	12	state	state	PROPN
gs-4060	18	13	medical	medical	PROPN
gs-4060	18	14	university	university	PROPN
gs-4060	18	15	,	,	PUNCT
gs-4060	18	16	department	department	NOUN
gs-4060	18	17	of	of	ADP
gs-4060	18	18	molecular	molecular	ADJ
gs-4060	18	19	and	and	CCONJ
gs-4060	18	20	medical	medical	ADJ
gs-4060	18	21	genetics	genetic	NOUN
gs-4060	18	22	,	,	PUNCT
gs-4060	18	23	invited	invite	VERB
gs-4060	18	24	professor	professor	NOUN
gs-4060	18	25	of	of	ADP
gs-4060	18	26	biochemistry	biochemistry	NOUN
gs-4060	18	27	and	and	CCONJ
gs-4060	18	28	molecular	molecular	ADJ
gs-4060	18	29	and	and	CCONJ
gs-4060	18	30	medical	medical	ADJ
gs-4060	18	31	genetics	genetic	NOUN
gs-4060	18	32	at	at	ADP
gs-4060	18	33	the	the	DET
gs-4060	18	34	university	university	PROPN
gs-4060	18	35	of	of	ADP
gs-4060	18	36	georgia	georgia	PROPN
gs-4060	18	37	;	;	PUNCT
gs-4060	18	38	tbilisi	tbilisi	PROPN
gs-4060	18	39	,	,	PUNCT
gs-4060	18	40	georgia	georgia	PROPN
gs-4060	18	41	.	.	PUNCT
gs-4060	19	1	15	15	NUM
gs-4060	19	2	.	.	X
gs-4060	20	1	md	md	PROPN
gs-4060	20	2	,	,	PUNCT
gs-4060	20	3	phd	phd	PROPN
gs-4060	20	4	,	,	PUNCT
gs-4060	20	5	doctor	doctor	PROPN
gs-4060	20	6	medical	medical	PROPN
gs-4060	20	7	sciences	sciences	PROPN
gs-4060	20	8	,	,	PUNCT
gs-4060	20	9	professor	professor	NOUN
gs-4060	20	10	of	of	ADP
gs-4060	20	11	the	the	DET
gs-4060	20	12	division	division	NOUN
gs-4060	20	13	of	of	ADP
gs-4060	20	14	dentistry	dentistry	NOUN
gs-4060	20	15	of	of	ADP
gs-4060	20	16	international	international	ADJ
gs-4060	20	17	school	school	NOUN
gs-4060	20	18	of	of	ADP
gs-4060	20	19	medicine	medicine	NOUN
gs-4060	20	20	at	at	ADP
gs-4060	20	21	alte	alte	PROPN
gs-4060	20	22	university	university	PROPN
gs-4060	20	23	;	;	PUNCT
gs-4060	20	24	professor	professor	NOUN
gs-4060	20	25	of	of	ADP
gs-4060	20	26	teaching	teach	VERB
gs-4060	20	27	university	university	NOUN
gs-4060	20	28	geomedi	geomedi	NOUN
gs-4060	20	29	,	,	PUNCT
gs-4060	20	30	invited	invite	VERB
gs-4060	20	31	professor	professor	NOUN
gs-4060	20	32	of	of	ADP
gs-4060	20	33	dentistry	dentistry	PROPN
gs-4060	20	34	department	department	PROPN
gs-4060	20	35	of	of	ADP
gs-4060	20	36	the	the	DET
gs-4060	20	37	school	school	NOUN
gs-4060	20	38	of	of	ADP
gs-4060	20	39	health	health	NOUN
gs-4060	20	40	sciences	science	NOUN
gs-4060	20	41	at	at	ADP
gs-4060	20	42	the	the	DET
gs-4060	20	43	university	university	PROPN
gs-4060	20	44	of	of	ADP
gs-4060	20	45	georgia	georgia	PROPN
gs-4060	20	46	,	,	PUNCT
gs-4060	20	47	tbilisi	tbilisi	PROPN
gs-4060	20	48	,	,	PUNCT
gs-4060	20	49	georgia	georgia	PROPN
gs-4060	20	50	.	.	PUNCT
gs-4060	21	1	16	16	NUM
gs-4060	21	2	.	.	PUNCT
gs-4060	22	1	md	md	PROPN
gs-4060	22	2	,	,	PUNCT
gs-4060	22	3	phd	phd	NOUN
gs-4060	22	4	,	,	PUNCT
gs-4060	22	5	doctor	doctor	NOUN
gs-4060	22	6	of	of	ADP
gs-4060	22	7	medical	medical	ADJ
gs-4060	22	8	sciences	science	NOUN
gs-4060	22	9	,	,	PUNCT
gs-4060	22	10	professor	professor	NOUN
gs-4060	22	11	of	of	ADP
gs-4060	22	12	faculty	faculty	NOUN
gs-4060	22	13	of	of	ADP
gs-4060	22	14	medicine	medicine	NOUN
gs-4060	22	15	at	at	ADP
gs-4060	22	16	caucasus	caucasus	PROPN
gs-4060	22	17	international	international	PROPN
gs-4060	22	18	university	university	PROPN
gs-4060	22	19	;	;	PUNCT
gs-4060	22	20	tbilisi	tbilisi	PROPN
gs-4060	22	21	,	,	PUNCT
gs-4060	22	22	georgia	georgia	PROPN
gs-4060	22	23	;	;	PUNCT
gs-4060	22	24	17	17	NUM
gs-4060	22	25	.	.	X
gs-4060	23	1	md	md	PROPN
gs-4060	23	2	,	,	PUNCT
gs-4060	23	3	phd	phd	NOUN
gs-4060	23	4	,	,	PUNCT
gs-4060	23	5	doctor	doctor	NOUN
gs-4060	23	6	of	of	ADP
gs-4060	23	7	medical	medical	ADJ
gs-4060	23	8	sciences	science	NOUN
gs-4060	23	9	,	,	PUNCT
gs-4060	23	10	academician	academician	NOUN
gs-4060	23	11	,	,	PUNCT
gs-4060	23	12	professor	professor	NOUN
gs-4060	23	13	of	of	ADP
gs-4060	23	14	faculty	faculty	NOUN
gs-4060	23	15	of	of	ADP
gs-4060	23	16	medicine	medicine	NOUN
gs-4060	23	17	at	at	ADP
gs-4060	23	18	caucasus	caucasus	PROPN
gs-4060	23	19	international	international	PROPN
gs-4060	23	20	university	university	PROPN
gs-4060	23	21	;	;	PUNCT
gs-4060	23	22	doctor	doctor	NOUN
gs-4060	23	23	-	-	PUNCT
gs-4060	23	24	professor	professor	NOUN
gs-4060	23	25	of	of	ADP
gs-4060	23	26	national	national	PROPN
gs-4060	23	27	health	health	PROPN
gs-4060	23	28	center	center	NOUN
gs-4060	23	29	named	name	VERB
gs-4060	23	30	after	after	ADP
gs-4060	23	31	academician	academician	PROPN
gs-4060	23	32	o.	o.	PROPN
gs-4060	23	33	gudushauri	gudushauri	PROPN
gs-4060	23	34	;	;	PUNCT
gs-4060	23	35	tbilisi	tbilisi	PROPN
gs-4060	23	36	,	,	PUNCT
gs-4060	23	37	georgia	georgia	PROPN
gs-4060	23	38	;	;	PUNCT
gs-4060	23	39	18	18	NUM
gs-4060	23	40	.	.	X
gs-4060	23	41	md	md	PROPN
gs-4060	23	42	,	,	PUNCT
gs-4060	23	43	phd	phd	NOUN
gs-4060	23	44	,	,	PUNCT
gs-4060	23	45	doctor	doctor	NOUN
gs-4060	23	46	of	of	ADP
gs-4060	23	47	medical	medical	ADJ
gs-4060	23	48	sciences	science	NOUN
gs-4060	23	49	,	,	PUNCT
gs-4060	23	50	academician	academician	NOUN
gs-4060	23	51	,	,	PUNCT
gs-4060	23	52	professor	professor	NOUN
gs-4060	23	53	of	of	ADP
gs-4060	23	54	tbilisi	tbilisi	PROPN
gs-4060	23	55	state	state	PROPN
gs-4060	23	56	medical	medical	PROPN
gs-4060	23	57	university	university	NOUN
gs-4060	23	58	,	,	PUNCT
gs-4060	23	59	faculty	faculty	NOUN
gs-4060	23	60	of	of	ADP
gs-4060	23	61	public	public	ADJ
gs-4060	23	62	health	health	NOUN
gs-4060	23	63	;	;	PUNCT
gs-4060	23	64	department	department	NOUN
gs-4060	23	65	of	of	ADP
gs-4060	23	66	hygiene	hygiene	NOUN
gs-4060	23	67	and	and	CCONJ
gs-4060	23	68	medical	medical	ADJ
gs-4060	23	69	ecology	ecology	NOUN
gs-4060	23	70	,	,	PUNCT
gs-4060	23	71	tbilisi	tbilisi	PROPN
gs-4060	23	72	,	,	PUNCT
gs-4060	23	73	georgia	georgia	PROPN
gs-4060	23	74	.	.	PUNCT
gs-4060	24	1	https://orcid.org/0000-0003-0686-5227	https://orcid.org/0000-0003-0686-5227	PROPN
gs-4060	24	2	19	19	NUM
gs-4060	24	3	.	.	PUNCT
gs-4060	24	4	md	md	PROPN
gs-4060	24	5	,	,	PUNCT
gs-4060	24	6	phd	phd	NOUN
gs-4060	24	7	,	,	PUNCT
gs-4060	24	8	doctor	doctor	NOUN
gs-4060	24	9	of	of	ADP
gs-4060	24	10	medical	medical	ADJ
gs-4060	24	11	sciences	science	NOUN
gs-4060	24	12	,	,	PUNCT
gs-4060	24	13	professor	professor	NOUN
gs-4060	24	14	of	of	ADP
gs-4060	24	15	tbilisi	tbilisi	PROPN
gs-4060	24	16	state	state	PROPN
gs-4060	24	17	medical	medical	PROPN
gs-4060	24	18	university	university	PROPN
gs-4060	24	19	,	,	PUNCT
gs-4060	24	20	department	department	NOUN
gs-4060	24	21	of	of	ADP
gs-4060	24	22	public	public	ADJ
gs-4060	24	23	health	health	NOUN
gs-4060	24	24	,	,	PUNCT
gs-4060	24	25	health	health	NOUN
gs-4060	24	26	care	care	NOUN
gs-4060	24	27	management	management	NOUN
gs-4060	24	28	,	,	PUNCT
gs-4060	24	29	policy	policy	NOUN
gs-4060	24	30	and	and	CCONJ
gs-4060	24	31	economy	economy	NOUN
gs-4060	24	32	,	,	PUNCT
gs-4060	24	33	tbilisi	tbilisi	PROPN
gs-4060	24	34	,	,	PUNCT
gs-4060	24	35	georgia	georgia	PROPN
gs-4060	24	36	.	.	PUNCT
gs-4060	25	1	20	20	NUM
gs-4060	25	2	.	.	X
gs-4060	26	1	md	md	PROPN
gs-4060	26	2	,	,	PUNCT
gs-4060	26	3	phd	phd	NOUN
gs-4060	26	4	,	,	PUNCT
gs-4060	26	5	doctor	doctor	NOUN
gs-4060	26	6	of	of	ADP
gs-4060	26	7	medical	medical	ADJ
gs-4060	26	8	sciences	science	NOUN
gs-4060	26	9	,	,	PUNCT
gs-4060	26	10	academician	academician	NOUN
gs-4060	26	11	,	,	PUNCT
gs-4060	26	12	professor	professor	NOUN
gs-4060	26	13	of	of	ADP
gs-4060	26	14	tbilisi	tbilisi	PROPN
gs-4060	26	15	state	state	PROPN
gs-4060	26	16	medical	medical	PROPN
gs-4060	26	17	university	university	PROPN
gs-4060	26	18	,	,	PUNCT
gs-4060	26	19	dean	dean	NOUN
gs-4060	26	20	of	of	ADP
gs-4060	26	21	the	the	DET
gs-4060	26	22	faculty	faculty	NOUN
gs-4060	26	23	of	of	ADP
gs-4060	26	24	public	public	ADJ
gs-4060	26	25	health	health	NOUN
gs-4060	26	26	,	,	PUNCT
gs-4060	26	27	head	head	NOUN
gs-4060	26	28	of	of	ADP
gs-4060	26	29	the	the	DET
gs-4060	26	30	department	department	NOUN
gs-4060	26	31	of	of	ADP
gs-4060	26	32	nutrition	nutrition	NOUN
gs-4060	26	33	,	,	PUNCT
gs-4060	26	34	aging	age	VERB
gs-4060	26	35	medicine	medicine	NOUN
gs-4060	26	36	,	,	PUNCT
gs-4060	26	37	environmental	environmental	ADJ
gs-4060	26	38	and	and	CCONJ
gs-4060	26	39	occupational	occupational	ADJ
gs-4060	26	40	health	health	NOUN
gs-4060	26	41	,	,	PUNCT
gs-4060	26	42	tbilisi	tbilisi	PROPN
gs-4060	26	43	,	,	PUNCT
gs-4060	26	44	georgia	georgia	PROPN
gs-4060	26	45	.	.	PUNCT
gs-4060	27	1	corresponding	correspond	VERB
gs-4060	27	2	author	author	NOUN
gs-4060	27	3	:	:	PUNCT
gs-4060	27	4	dr	dr	PROPN
gs-4060	27	5	.	.	PROPN
gs-4060	27	6	professor	professor	PROPN
gs-4060	27	7	nodar	nodar	PROPN
gs-4060	27	8	sulashvili	sulashvili	PROPN
gs-4060	27	9	mail	mail	NOUN
gs-4060	27	10	:	:	PUNCT
gs-4060	27	11	n.sulashvili@ug.edu.ge	n.sulashvili@ug.edu.ge	NOUN
gs-4060	27	12	mob	mob	NOUN
gs-4060	27	13	:	:	PUNCT
gs-4060	28	1	+995	+995	ADJ
gs-4060	28	2	-	-	ADJ
gs-4060	28	3	597	597	NUM
gs-4060	28	4	-	-	PUNCT
gs-4060	28	5	12	12	NUM
gs-4060	28	6	-	-	PUNCT
gs-4060	28	7	17	17	NUM
gs-4060	28	8	-	-	SYM
gs-4060	28	9	28	28	NUM
gs-4060	28	10	abstract	abstract	NOUN
gs-4060	28	11	the	the	DET
gs-4060	28	12	landscape	landscape	NOUN
gs-4060	28	13	of	of	ADP
gs-4060	28	14	anticancer	anticancer	NOUN
gs-4060	28	15	drug	drug	NOUN
gs-4060	28	16	development	development	NOUN
gs-4060	28	17	has	have	AUX
gs-4060	28	18	transformed	transform	VERB
gs-4060	28	19	with	with	ADP
gs-4060	28	20	the	the	DET
gs-4060	28	21	advent	advent	NOUN
gs-4060	28	22	of	of	ADP
gs-4060	28	23	targeted	target	VERB
gs-4060	28	24	therapies	therapy	NOUN
gs-4060	28	25	,	,	PUNCT
gs-4060	28	26	immunotherapies	immunotherapy	NOUN
gs-4060	28	27	,	,	PUNCT
gs-4060	28	28	and	and	CCONJ
gs-4060	28	29	novel	novel	ADJ
gs-4060	28	30	delivery	delivery	NOUN
gs-4060	28	31	systems	system	NOUN
gs-4060	28	32	,	,	PUNCT
gs-4060	28	33	addressing	address	VERB
gs-4060	28	34	the	the	DET
gs-4060	28	35	global	global	ADJ
gs-4060	28	36	burden	burden	NOUN
gs-4060	28	37	of	of	ADP
gs-4060	28	38	cancer	cancer	NOUN
gs-4060	28	39	,	,	PUNCT
gs-4060	28	40	projected	project	VERB
gs-4060	28	41	to	to	PART
gs-4060	28	42	reach	reach	VERB
gs-4060	28	43	28.4	28.4	NUM
gs-4060	28	44	million	million	NUM
gs-4060	28	45	cases	case	NOUN
gs-4060	28	46	by	by	ADP
gs-4060	28	47	2040	2040	NUM
gs-4060	28	48	.	.	PUNCT
gs-4060	29	1	this	this	DET
gs-4060	29	2	article	article	NOUN
gs-4060	29	3	comprehensively	comprehensively	ADV
gs-4060	29	4	reviews	review	VERB
gs-4060	29	5	the	the	DET
gs-4060	29	6	classification	classification	NOUN
gs-4060	29	7	,	,	PUNCT
gs-4060	29	8	clinical	clinical	ADJ
gs-4060	29	9	use	use	NOUN
gs-4060	29	10	,	,	PUNCT
gs-4060	29	11	features	feature	NOUN
gs-4060	29	12	,	,	PUNCT
gs-4060	29	13	mechanisms	mechanism	NOUN
gs-4060	29	14	of	of	ADP
gs-4060	29	15	action	action	NOUN
gs-4060	29	16	,	,	PUNCT
gs-4060	29	17	pharmacology	pharmacology	NOUN
gs-4060	29	18	,	,	PUNCT
gs-4060	29	19	therapeutic	therapeutic	ADJ
gs-4060	29	20	effects	effect	NOUN
gs-4060	29	21	,	,	PUNCT
gs-4060	29	22	and	and	CCONJ
gs-4060	29	23	toxicities	toxicity	NOUN
gs-4060	29	24	of	of	ADP
gs-4060	29	25	new	new	ADJ
gs-4060	29	26	anticancer	anticancer	NOUN
gs-4060	29	27	drugs	drug	NOUN
gs-4060	29	28	,	,	PUNCT
gs-4060	29	29	focusing	focus	VERB
gs-4060	29	30	on	on	ADP
gs-4060	29	31	agents	agent	NOUN
gs-4060	29	32	approved	approve	VERB
gs-4060	29	33	by	by	ADP
gs-4060	29	34	the	the	DET
gs-4060	29	35	fda	fda	PROPN
gs-4060	29	36	and	and	CCONJ
gs-4060	29	37	ema	ema	PROPN
gs-4060	29	38	as	as	ADP
gs-4060	29	39	of	of	ADP
gs-4060	29	40	march	march	PROPN
gs-4060	29	41	2024	2024	NUM
gs-4060	29	42	.	.	PUNCT
gs-4060	30	1	drugs	drug	NOUN
gs-4060	30	2	are	be	AUX
gs-4060	30	3	classified	classify	VERB
gs-4060	30	4	by	by	ADP
gs-4060	30	5	their	their	PRON
gs-4060	30	6	site	site	NOUN
gs-4060	30	7	of	of	ADP
gs-4060	30	8	action	action	NOUN
gs-4060	30	9	(	(	PUNCT
gs-4060	30	10	e.g.	e.g.	ADV
gs-4060	30	11	,	,	PUNCT
gs-4060	30	12	tumor	tumor	NOUN
gs-4060	30	13	cell	cell	NOUN
gs-4060	30	14	nucleus	nucleus	NOUN
gs-4060	30	15	,	,	PUNCT
gs-4060	30	16	cytoplasm	cytoplasm	ADJ
gs-4060	30	17	,	,	PUNCT
gs-4060	30	18	vasculature	vasculature	NOUN
gs-4060	30	19	,	,	PUNCT
gs-4060	30	20	immune	immune	NOUN
gs-4060	30	21	,	,	PUNCT
gs-4060	30	22	and	and	CCONJ
gs-4060	30	23	endocrine	endocrine	NOUN
gs-4060	30	24	systems	system	NOUN
gs-4060	30	25	)	)	PUNCT
gs-4060	30	26	and	and	CCONJ
gs-4060	30	27	mechanism	mechanism	NOUN
gs-4060	30	28	(	(	PUNCT
gs-4060	30	29	e.g.	e.g.	ADV
gs-4060	30	30	,	,	PUNCT
gs-4060	30	31	dna	dna	NOUN
gs-4060	30	32	damage	damage	NOUN
gs-4060	30	33	,	,	PUNCT
gs-4060	30	34	kinase	kinase	NOUN
gs-4060	30	35	inhibition	inhibition	NOUN
gs-4060	30	36	,	,	PUNCT
gs-4060	30	37	immune	immune	ADJ
gs-4060	30	38	modulation	modulation	NOUN
gs-4060	30	39	)	)	PUNCT
gs-4060	30	40	.	.	PUNCT
gs-4060	31	1	key	key	ADJ
gs-4060	31	2	classes	class	NOUN
gs-4060	31	3	include	include	VERB
gs-4060	31	4	antibody	antibody	NOUN
gs-4060	31	5	-	-	PUNCT
gs-4060	31	6	drug	drug	NOUN
gs-4060	31	7	conjugates	conjugate	NOUN
gs-4060	31	8	(	(	PUNCT
gs-4060	31	9	adcs	adcs	ADJ
gs-4060	31	10	)	)	PUNCT
gs-4060	31	11	like	like	ADP
gs-4060	31	12	trastuzumab	trastuzumab	NOUN
gs-4060	31	13	deruxtecan	deruxtecan	ADJ
gs-4060	31	14	,	,	PUNCT
gs-4060	31	15	tyrosine	tyrosine	NOUN
gs-4060	31	16	kinase	kinase	PROPN
gs-4060	31	17	inhibitors	inhibitor	NOUN
gs-4060	31	18	(	(	PUNCT
gs-4060	31	19	e.g.	e.g.	ADV
gs-4060	31	20	,	,	PUNCT
gs-4060	31	21	osimertinib	osimertinib	NOUN
gs-4060	31	22	)	)	PUNCT
gs-4060	31	23	,	,	PUNCT
gs-4060	31	24	immune	immune	ADJ
gs-4060	31	25	checkpoint	checkpoint	NOUN
gs-4060	31	26	inhibitors	inhibitor	NOUN
gs-4060	31	27	(	(	PUNCT
gs-4060	31	28	e.g.	e.g.	ADV
gs-4060	31	29	,	,	PUNCT
gs-4060	31	30	pembrolizumab	pembrolizumab	NOUN
gs-4060	31	31	)	)	PUNCT
gs-4060	31	32	,	,	PUNCT
gs-4060	31	33	and	and	CCONJ
gs-4060	31	34	natural	natural	ADJ
gs-4060	31	35	or	or	CCONJ
gs-4060	31	36	repurposed	repurposed	ADJ
gs-4060	31	37	agents	agent	NOUN
gs-4060	31	38	(	(	PUNCT
gs-4060	31	39	e.g.	e.g.	ADV
gs-4060	31	40	,	,	PUNCT
gs-4060	31	41	paclitaxel	paclitaxel	NOUN
gs-4060	31	42	,	,	PUNCT
gs-4060	31	43	metformin	metformin	PROPN
gs-4060	31	44	)	)	PUNCT
gs-4060	31	45	.	.	PUNCT
gs-4060	32	1	mechanisms	mechanism	NOUN
gs-4060	32	2	range	range	VERB
gs-4060	32	3	from	from	ADP
gs-4060	32	4	dna	dna	PROPN
gs-4060	32	5	crossgeorgian	crossgeorgian	PROPN
gs-4060	32	6	scientists/	scientists/	NUM
gs-4060	32	7	.	.	PUNCT
gs-4060	33	1	7	7	NUM
gs-4060	33	2	n	n	PRON
gs-4060	33	3	3	3	NUM
gs-4060	33	4	,	,	PUNCT
gs-4060	33	5	2025	2025	NUM
gs-4060	33	6	572	572	NUM
gs-4060	33	7	linking	linking	NOUN
gs-4060	33	8	and	and	CCONJ
gs-4060	33	9	microtubule	microtubule	VERB
gs-4060	33	10	disruption	disruption	NOUN
gs-4060	33	11	to	to	ADP
gs-4060	33	12	immune	immune	ADJ
gs-4060	33	13	activation	activation	NOUN
gs-4060	33	14	and	and	CCONJ
gs-4060	33	15	angiogenesis	angiogenesis	NOUN
gs-4060	33	16	inhibition	inhibition	NOUN
gs-4060	33	17	.	.	PUNCT
gs-4060	34	1	pharmacologically	pharmacologically	ADV
gs-4060	34	2	,	,	PUNCT
gs-4060	34	3	small	small	ADJ
gs-4060	34	4	molecules	molecule	NOUN
gs-4060	34	5	offer	offer	VERB
gs-4060	34	6	oral	oral	ADJ
gs-4060	34	7	bioavailability	bioavailability	NOUN
gs-4060	34	8	but	but	CCONJ
gs-4060	34	9	face	face	VERB
gs-4060	34	10	metabolism	metabolism	NOUN
gs-4060	34	11	challenges	challenge	NOUN
gs-4060	34	12	,	,	PUNCT
gs-4060	34	13	while	while	SCONJ
gs-4060	34	14	biologics	biologic	NOUN
gs-4060	34	15	require	require	VERB
gs-4060	34	16	parenteral	parenteral	ADJ
gs-4060	34	17	administration	administration	NOUN
gs-4060	34	18	.	.	PUNCT
gs-4060	35	1	advanced	advanced	ADJ
gs-4060	35	2	delivery	delivery	NOUN
gs-4060	35	3	systems	system	NOUN
gs-4060	35	4	,	,	PUNCT
gs-4060	35	5	such	such	ADJ
gs-4060	35	6	as	as	ADP
gs-4060	35	7	nanoparticles	nanoparticle	NOUN
gs-4060	35	8	and	and	CCONJ
gs-4060	35	9	adcs	adc	NOUN
gs-4060	35	10	,	,	PUNCT
gs-4060	35	11	enhance	enhance	VERB
gs-4060	35	12	specificity	specificity	NOUN
gs-4060	35	13	.	.	PUNCT
gs-4060	36	1	therapeutic	therapeutic	ADJ
gs-4060	36	2	effects	effect	NOUN
gs-4060	36	3	include	include	VERB
gs-4060	36	4	improved	improve	VERB
gs-4060	36	5	overall	overall	ADJ
gs-4060	36	6	survival	survival	NOUN
gs-4060	36	7	and	and	CCONJ
gs-4060	36	8	response	response	NOUN
gs-4060	36	9	rates	rate	NOUN
gs-4060	36	10	,	,	PUNCT
gs-4060	36	11	though	though	SCONJ
gs-4060	36	12	toxicities	toxicity	NOUN
gs-4060	36	13	like	like	ADP
gs-4060	36	14	myelosuppression	myelosuppression	NOUN
gs-4060	36	15	,	,	PUNCT
gs-4060	36	16	cardiotoxicity	cardiotoxicity	NOUN
gs-4060	36	17	,	,	PUNCT
gs-4060	36	18	and	and	CCONJ
gs-4060	36	19	immune	immune	NOUN
gs-4060	36	20	-	-	PUNCT
gs-4060	36	21	related	relate	VERB
gs-4060	36	22	adverse	adverse	ADJ
gs-4060	36	23	events	event	NOUN
gs-4060	36	24	persist	persist	VERB
gs-4060	36	25	.	.	PUNCT
gs-4060	37	1	emerging	emerge	VERB
gs-4060	37	2	approaches	approach	NOUN
gs-4060	37	3	,	,	PUNCT
gs-4060	37	4	including	include	VERB
gs-4060	37	5	nanotechnology	nanotechnology	NOUN
gs-4060	37	6	,	,	PUNCT
gs-4060	37	7	natural	natural	ADJ
gs-4060	37	8	products	product	NOUN
gs-4060	37	9	,	,	PUNCT
gs-4060	37	10	and	and	CCONJ
gs-4060	37	11	drug	drug	NOUN
gs-4060	37	12	repurposing	repurposing	NOUN
gs-4060	37	13	,	,	PUNCT
gs-4060	37	14	alongside	alongside	ADP
gs-4060	37	15	ai	ai	ADJ
gs-4060	37	16	-	-	PUNCT
gs-4060	37	17	driven	drive	VERB
gs-4060	37	18	design	design	NOUN
gs-4060	37	19	,	,	PUNCT
gs-4060	37	20	promise	promise	VERB
gs-4060	37	21	to	to	PART
gs-4060	37	22	overcome	overcome	VERB
gs-4060	37	23	resistance	resistance	NOUN
gs-4060	37	24	and	and	CCONJ
gs-4060	37	25	optimize	optimize	VERB
gs-4060	37	26	outcomes	outcome	NOUN
gs-4060	37	27	.	.	PUNCT
gs-4060	38	1	this	this	DET
gs-4060	38	2	review	review	NOUN
gs-4060	38	3	underscores	underscore	VERB
gs-4060	38	4	the	the	DET
gs-4060	38	5	scientific	scientific	ADJ
gs-4060	38	6	advancements	advancement	NOUN
gs-4060	38	7	driving	drive	VERB
gs-4060	38	8	precision	precision	NOUN
gs-4060	38	9	oncology	oncology	NOUN
gs-4060	38	10	while	while	SCONJ
gs-4060	38	11	highlighting	highlight	VERB
gs-4060	38	12	challenges	challenge	NOUN
gs-4060	38	13	in	in	ADP
gs-4060	38	14	toxicity	toxicity	NOUN
gs-4060	38	15	management	management	NOUN
gs-4060	38	16	and	and	CCONJ
gs-4060	38	17	global	global	ADJ
gs-4060	38	18	accessibility	accessibility	NOUN
gs-4060	38	19	.	.	PUNCT
gs-4060	39	1	the	the	DET
gs-4060	39	2	landscape	landscape	NOUN
gs-4060	39	3	of	of	ADP
gs-4060	39	4	oncology	oncology	NOUN
gs-4060	39	5	therapeutics	therapeutic	NOUN
gs-4060	39	6	has	have	AUX
gs-4060	39	7	been	be	AUX
gs-4060	39	8	radically	radically	ADV
gs-4060	39	9	transformed	transform	VERB
gs-4060	39	10	by	by	ADP
gs-4060	39	11	the	the	DET
gs-4060	39	12	development	development	NOUN
gs-4060	39	13	of	of	ADP
gs-4060	39	14	new	new	ADJ
gs-4060	39	15	anticancer	anticancer	NOUN
gs-4060	39	16	drugs	drug	NOUN
gs-4060	39	17	that	that	PRON
gs-4060	39	18	move	move	VERB
gs-4060	39	19	beyond	beyond	ADP
gs-4060	39	20	traditional	traditional	ADJ
gs-4060	39	21	cytotoxic	cytotoxic	ADJ
gs-4060	39	22	agents	agent	NOUN
gs-4060	39	23	.	.	PUNCT
gs-4060	40	1	this	this	DET
gs-4060	40	2	review	review	NOUN
gs-4060	40	3	comprehensively	comprehensively	ADV
gs-4060	40	4	examines	examine	VERB
gs-4060	40	5	the	the	DET
gs-4060	40	6	scientific	scientific	ADJ
gs-4060	40	7	aspects	aspect	NOUN
gs-4060	40	8	of	of	ADP
gs-4060	40	9	these	these	DET
gs-4060	40	10	novel	novel	ADJ
gs-4060	40	11	compounds	compound	NOUN
gs-4060	40	12	,	,	PUNCT
gs-4060	40	13	focusing	focus	VERB
gs-4060	40	14	on	on	ADP
gs-4060	40	15	their	their	PRON
gs-4060	40	16	modern	modern	ADJ
gs-4060	40	17	classification	classification	NOUN
gs-4060	40	18	,	,	PUNCT
gs-4060	40	19	intricate	intricate	ADJ
gs-4060	40	20	mechanisms	mechanism	NOUN
gs-4060	40	21	of	of	ADP
gs-4060	40	22	action	action	NOUN
gs-4060	40	23	,	,	PUNCT
gs-4060	40	24	and	and	CCONJ
gs-4060	40	25	clinical	clinical	ADJ
gs-4060	40	26	applications	application	NOUN
gs-4060	40	27	.	.	PUNCT
gs-4060	41	1	we	we	PRON
gs-4060	41	2	categorize	categorize	VERB
gs-4060	41	3	these	these	DET
gs-4060	41	4	agents	agent	NOUN
gs-4060	41	5	into	into	ADP
gs-4060	41	6	targeted	target	VERB
gs-4060	41	7	therapies	therapy	NOUN
gs-4060	41	8	,	,	PUNCT
gs-4060	41	9	including	include	VERB
gs-4060	41	10	small	small	ADJ
gs-4060	41	11	molecule	molecule	NOUN
gs-4060	41	12	inhibitors	inhibitor	NOUN
gs-4060	41	13	and	and	CCONJ
gs-4060	41	14	monoclonal	monoclonal	NOUN
gs-4060	41	15	antibodies	antibody	NOUN
gs-4060	41	16	designed	design	VERB
gs-4060	41	17	against	against	ADP
gs-4060	41	18	specific	specific	ADJ
gs-4060	41	19	molecular	molecular	ADJ
gs-4060	41	20	aberrations	aberration	NOUN
gs-4060	41	21	(	(	PUNCT
gs-4060	41	22	e.g.	e.g.	ADV
gs-4060	41	23	,	,	PUNCT
gs-4060	41	24	kinase	kinase	NOUN
gs-4060	41	25	activity	activity	NOUN
gs-4060	41	26	,	,	PUNCT
gs-4060	41	27	signaling	signal	VERB
gs-4060	41	28	pathways	pathway	NOUN
gs-4060	41	29	)	)	PUNCT
gs-4060	41	30	,	,	PUNCT
gs-4060	41	31	and	and	CCONJ
gs-4060	41	32	immunotherapeutic	immunotherapeutic	ADJ
gs-4060	41	33	agents	agent	NOUN
gs-4060	41	34	,	,	PUNCT
gs-4060	41	35	such	such	ADJ
gs-4060	41	36	as	as	ADP
gs-4060	41	37	immune	immune	ADJ
gs-4060	41	38	checkpoint	checkpoint	NOUN
gs-4060	41	39	inhibitors	inhibitor	NOUN
gs-4060	41	40	(	(	PUNCT
gs-4060	41	41	e.g.	e.g.	ADV
gs-4060	41	42	,	,	PUNCT
gs-4060	41	43	pd-1	pd-1	ADJ
gs-4060	41	44	/	/	SYM
gs-4060	41	45	pd	pd	NOUN
gs-4060	41	46	-	-	PUNCT
gs-4060	41	47	l1	l1	PROPN
gs-4060	41	48	,	,	PUNCT
gs-4060	41	49	ctla-4	ctla-4	NOUN
gs-4060	41	50	inhibitors	inhibitor	NOUN
gs-4060	41	51	)	)	PUNCT
gs-4060	41	52	,	,	PUNCT
gs-4060	41	53	car	car	NOUN
gs-4060	41	54	-	-	PUNCT
gs-4060	41	55	t	t	NOUN
gs-4060	41	56	cells	cell	NOUN
gs-4060	41	57	,	,	PUNCT
gs-4060	41	58	and	and	CCONJ
gs-4060	41	59	cancer	cancer	NOUN
gs-4060	41	60	vaccines	vaccine	NOUN
gs-4060	41	61	,	,	PUNCT
gs-4060	41	62	which	which	PRON
gs-4060	41	63	harness	harnes	VERB
gs-4060	41	64	the	the	DET
gs-4060	41	65	host	host	NOUN
gs-4060	41	66	's	's	PART
gs-4060	41	67	immune	immune	ADJ
gs-4060	41	68	system	system	NOUN
gs-4060	41	69	to	to	PART
gs-4060	41	70	combat	combat	VERB
gs-4060	41	71	malignancy	malignancy	NOUN
gs-4060	41	72	.	.	PUNCT
gs-4060	42	1	the	the	DET
gs-4060	42	2	discussion	discussion	NOUN
gs-4060	42	3	delves	delve	VERB
gs-4060	42	4	into	into	ADP
gs-4060	42	5	the	the	DET
gs-4060	42	6	unique	unique	ADJ
gs-4060	42	7	pharmacologic	pharmacologic	ADJ
gs-4060	42	8	features	feature	NOUN
gs-4060	42	9	of	of	ADP
gs-4060	42	10	these	these	DET
gs-4060	42	11	drugs	drug	NOUN
gs-4060	42	12	,	,	PUNCT
gs-4060	42	13	including	include	VERB
gs-4060	42	14	their	their	PRON
gs-4060	42	15	design	design	NOUN
gs-4060	42	16	principles	principle	NOUN
gs-4060	42	17	,	,	PUNCT
gs-4060	42	18	structure	structure	NOUN
gs-4060	42	19	-	-	PUNCT
gs-4060	42	20	activity	activity	NOUN
gs-4060	42	21	relationships	relationship	NOUN
gs-4060	42	22	,	,	PUNCT
gs-4060	42	23	and	and	CCONJ
gs-4060	42	24	pharmacokinetic	pharmacokinetic	ADJ
gs-4060	42	25	profiles	profile	NOUN
gs-4060	42	26	,	,	PUNCT
gs-4060	42	27	which	which	PRON
gs-4060	42	28	often	often	ADV
gs-4060	42	29	differ	differ	VERB
gs-4060	42	30	significantly	significantly	ADV
gs-4060	42	31	from	from	ADP
gs-4060	42	32	conventional	conventional	ADJ
gs-4060	42	33	chemotherapy	chemotherapy	NOUN
gs-4060	42	34	.	.	PUNCT
gs-4060	43	1	a	a	DET
gs-4060	43	2	detailed	detailed	ADJ
gs-4060	43	3	analysis	analysis	NOUN
gs-4060	43	4	of	of	ADP
gs-4060	43	5	their	their	PRON
gs-4060	43	6	precise	precise	ADJ
gs-4060	43	7	mechanisms	mechanism	NOUN
gs-4060	43	8	of	of	ADP
gs-4060	43	9	action	action	NOUN
gs-4060	43	10	elucidates	elucidate	VERB
gs-4060	43	11	how	how	SCONJ
gs-4060	43	12	they	they	PRON
gs-4060	43	13	induce	induce	VERB
gs-4060	43	14	cell	cell	NOUN
gs-4060	43	15	cycle	cycle	NOUN
gs-4060	43	16	arrest	arrest	NOUN
gs-4060	43	17	,	,	PUNCT
gs-4060	43	18	promote	promote	VERB
gs-4060	43	19	apoptosis	apoptosis	NOUN
gs-4060	43	20	,	,	PUNCT
gs-4060	43	21	inhibit	inhibit	NOUN
gs-4060	43	22	angiogenesis	angiogenesis	NOUN
gs-4060	43	23	,	,	PUNCT
gs-4060	43	24	and	and	CCONJ
gs-4060	43	25	modulate	modulate	VERB
gs-4060	43	26	the	the	DET
gs-4060	43	27	tumor	tumor	NOUN
gs-4060	43	28	microenvironment	microenvironment	NOUN
gs-4060	43	29	.	.	PUNCT
gs-4060	44	1	while	while	SCONJ
gs-4060	44	2	these	these	DET
gs-4060	44	3	therapies	therapy	NOUN
gs-4060	44	4	offer	offer	VERB
gs-4060	44	5	superior	superior	ADJ
gs-4060	44	6	efficacy	efficacy	NOUN
gs-4060	44	7	and	and	CCONJ
gs-4060	44	8	reduced	reduce	VERB
gs-4060	44	9	off	off	ADP
gs-4060	44	10	-	-	PUNCT
gs-4060	44	11	target	target	NOUN
gs-4060	44	12	effects	effect	NOUN
gs-4060	44	13	in	in	ADP
gs-4060	44	14	specific	specific	ADJ
gs-4060	44	15	patient	patient	ADJ
gs-4060	44	16	populations	population	NOUN
gs-4060	44	17	,	,	PUNCT
gs-4060	44	18	they	they	PRON
gs-4060	44	19	are	be	AUX
gs-4060	44	20	associated	associate	VERB
gs-4060	44	21	with	with	ADP
gs-4060	44	22	a	a	DET
gs-4060	44	23	distinct	distinct	ADJ
gs-4060	44	24	spectrum	spectrum	NOUN
gs-4060	44	25	of	of	ADP
gs-4060	44	26	adverse	adverse	ADJ
gs-4060	44	27	effects	effect	NOUN
gs-4060	44	28	and	and	CCONJ
gs-4060	44	29	toxicities	toxicity	NOUN
gs-4060	44	30	,	,	PUNCT
gs-4060	44	31	such	such	ADJ
gs-4060	44	32	as	as	ADP
gs-4060	44	33	immune	immune	NOUN
gs-4060	44	34	-	-	PUNCT
gs-4060	44	35	related	relate	VERB
gs-4060	44	36	adverse	adverse	ADJ
gs-4060	44	37	events	event	NOUN
gs-4060	44	38	(	(	PUNCT
gs-4060	44	39	iraes	iraes	NOUN
gs-4060	44	40	)	)	PUNCT
gs-4060	44	41	,	,	PUNCT
gs-4060	44	42	dermatologic	dermatologic	ADJ
gs-4060	44	43	reactions	reaction	NOUN
gs-4060	44	44	,	,	PUNCT
gs-4060	44	45	and	and	CCONJ
gs-4060	44	46	unique	unique	ADJ
gs-4060	44	47	organ	organ	NOUN
gs-4060	44	48	-	-	PUNCT
gs-4060	44	49	specific	specific	ADJ
gs-4060	44	50	inflammatory	inflammatory	ADJ
gs-4060	44	51	syndromes	syndrome	NOUN
gs-4060	44	52	,	,	PUNCT
gs-4060	44	53	which	which	PRON
gs-4060	44	54	necessitate	necessitate	ADJ
gs-4060	44	55	specialized	specialized	ADJ
gs-4060	44	56	management	management	NOUN
gs-4060	44	57	protocols	protocol	NOUN
gs-4060	44	58	.	.	PUNCT
gs-4060	45	1	this	this	DET
gs-4060	45	2	synthesis	synthesis	NOUN
gs-4060	45	3	underscores	underscore	VERB
gs-4060	45	4	the	the	DET
gs-4060	45	5	paradigm	paradigm	NOUN
gs-4060	45	6	shift	shift	NOUN
gs-4060	45	7	towards	towards	ADP
gs-4060	45	8	personalized	personalized	ADJ
gs-4060	45	9	medicine	medicine	NOUN
gs-4060	45	10	in	in	ADP
gs-4060	45	11	oncology	oncology	NOUN
gs-4060	45	12	,	,	PUNCT
gs-4060	45	13	driven	drive	VERB
gs-4060	45	14	by	by	ADP
gs-4060	45	15	biomarker	biomarker	NOUN
gs-4060	45	16	-	-	PUNCT
gs-4060	45	17	driven	drive	VERB
gs-4060	45	18	drug	drug	NOUN
gs-4060	45	19	selection	selection	NOUN
gs-4060	45	20	.	.	PUNCT
gs-4060	46	1	it	it	PRON
gs-4060	46	2	highlights	highlight	VERB
gs-4060	46	3	the	the	DET
gs-4060	46	4	critical	critical	ADJ
gs-4060	46	5	interplay	interplay	NOUN
gs-4060	46	6	between	between	ADP
gs-4060	46	7	molecular	molecular	ADJ
gs-4060	46	8	pathology	pathology	NOUN
gs-4060	46	9	,	,	PUNCT
gs-4060	46	10	drug	drug	NOUN
gs-4060	46	11	design	design	NOUN
gs-4060	46	12	,	,	PUNCT
gs-4060	46	13	clinical	clinical	ADJ
gs-4060	46	14	efficacy	efficacy	NOUN
gs-4060	46	15	,	,	PUNCT
gs-4060	46	16	and	and	CCONJ
gs-4060	46	17	toxicity	toxicity	NOUN
gs-4060	46	18	management	management	NOUN
gs-4060	46	19	,	,	PUNCT
gs-4060	46	20	while	while	SCONJ
gs-4060	46	21	also	also	ADV
gs-4060	46	22	acknowledging	acknowledge	VERB
gs-4060	46	23	ongoing	ongoing	ADJ
gs-4060	46	24	challenges	challenge	NOUN
gs-4060	46	25	like	like	ADP
gs-4060	46	26	drug	drug	NOUN
gs-4060	46	27	resistance	resistance	NOUN
gs-4060	46	28	and	and	CCONJ
gs-4060	46	29	the	the	DET
gs-4060	46	30	imperative	imperative	NOUN
gs-4060	46	31	for	for	ADP
gs-4060	46	32	continued	continued	ADJ
gs-4060	46	33	research	research	NOUN
gs-4060	46	34	into	into	ADP
gs-4060	46	35	novel	novel	ADJ
gs-4060	46	36	targets	target	NOUN
gs-4060	46	37	and	and	CCONJ
gs-4060	46	38	combination	combination	NOUN
gs-4060	46	39	strategies	strategy	NOUN
gs-4060	46	40	to	to	PART
gs-4060	46	41	improve	improve	VERB
gs-4060	46	42	patient	patient	ADJ
gs-4060	46	43	outcomes	outcome	NOUN
gs-4060	46	44	.	.	PUNCT
gs-4060	47	1	keywords	keyword	NOUN
gs-4060	47	2	:	:	PUNCT
gs-4060	47	3	novel	novel	ADJ
gs-4060	47	4	anticancer	anticancer	NOUN
gs-4060	47	5	drugs	drug	NOUN
gs-4060	47	6	,	,	PUNCT
gs-4060	47	7	targeted	target	VERB
gs-4060	47	8	therapy	therapy	NOUN
gs-4060	47	9	,	,	PUNCT
gs-4060	47	10	immunotherapy	immunotherapy	NOUN
gs-4060	47	11	,	,	PUNCT
gs-4060	47	12	mechanism	mechanism	NOUN
gs-4060	47	13	of	of	ADP
gs-4060	47	14	action	action	NOUN
gs-4060	47	15	,	,	PUNCT
gs-4060	47	16	pharmacokinetics	pharmacokinetic	NOUN
gs-4060	47	17	,	,	PUNCT
gs-4060	47	18	immune	immune	NOUN
gs-4060	47	19	-	-	PUNCT
gs-4060	47	20	related	relate	VERB
gs-4060	47	21	adverse	adverse	ADJ
gs-4060	47	22	events	event	NOUN
gs-4060	47	23	,	,	PUNCT
gs-4060	47	24	precision	precision	NOUN
gs-4060	47	25	oncology	oncology	NOUN
gs-4060	47	26	,	,	PUNCT
gs-4060	47	27	tyrosine	tyrosine	NOUN
gs-4060	47	28	kinase	kinase	PROPN
gs-4060	47	29	inhibitors	inhibitor	NOUN
gs-4060	47	30	,	,	PUNCT
gs-4060	47	31	monoclonal	monoclonal	NOUN
gs-4060	47	32	antibodies	antibody	NOUN
gs-4060	47	33	,	,	PUNCT
gs-4060	47	34	car	car	NOUN
gs-4060	47	35	-	-	PUNCT
gs-4060	47	36	t	t	NOUN
gs-4060	47	37	cell	cell	NOUN
gs-4060	47	38	therapy	therapy	NOUN
gs-4060	47	39	.	.	PUNCT
gs-4060	48	1	introduction	introduction	NOUN
gs-4060	48	2	cancer	cancer	NOUN
gs-4060	48	3	remains	remain	VERB
gs-4060	48	4	a	a	DET
gs-4060	48	5	formidable	formidable	ADJ
gs-4060	48	6	global	global	ADJ
gs-4060	48	7	health	health	NOUN
gs-4060	48	8	challenge	challenge	NOUN
gs-4060	48	9	,	,	PUNCT
gs-4060	48	10	with	with	ADP
gs-4060	48	11	profound	profound	ADJ
gs-4060	48	12	impacts	impact	NOUN
gs-4060	48	13	on	on	ADP
gs-4060	48	14	morbidity	morbidity	NOUN
gs-4060	48	15	and	and	CCONJ
gs-4060	48	16	mortality	mortality	NOUN
gs-4060	48	17	.	.	PUNCT
gs-4060	49	1	according	accord	VERB
gs-4060	49	2	to	to	ADP
gs-4060	49	3	the	the	DET
gs-4060	49	4	world	world	PROPN
gs-4060	49	5	health	health	PROPN
gs-4060	49	6	organization	organization	PROPN
gs-4060	49	7	,	,	PUNCT
gs-4060	49	8	cancer	cancer	NOUN
gs-4060	49	9	accounted	account	VERB
gs-4060	49	10	for	for	ADP
gs-4060	49	11	approximately	approximately	ADV
gs-4060	49	12	19.3	19.3	NUM
gs-4060	49	13	million	million	NUM
gs-4060	49	14	new	new	ADJ
gs-4060	49	15	cases	case	NOUN
gs-4060	49	16	and	and	CCONJ
gs-4060	49	17	10	10	NUM
gs-4060	49	18	million	million	NUM
gs-4060	49	19	deaths	death	NOUN
gs-4060	49	20	worldwide	worldwide	ADV
gs-4060	49	21	in	in	ADP
gs-4060	49	22	2020	2020	NUM
gs-4060	49	23	,	,	PUNCT
gs-4060	49	24	with	with	ADP
gs-4060	49	25	projections	projection	NOUN
gs-4060	49	26	estimating	estimate	VERB
gs-4060	49	27	a	a	DET
gs-4060	49	28	rise	rise	NOUN
gs-4060	49	29	to	to	ADP
gs-4060	49	30	28.4	28.4	NUM
gs-4060	49	31	million	million	NUM
gs-4060	49	32	new	new	ADJ
gs-4060	49	33	cases	case	NOUN
gs-4060	49	34	by	by	ADP
gs-4060	49	35	2040	2040	NUM
gs-4060	49	36	.	.	PUNCT
gs-4060	50	1	this	this	DET
gs-4060	50	2	escalation	escalation	NOUN
gs-4060	50	3	is	be	AUX
gs-4060	50	4	driven	drive	VERB
gs-4060	50	5	by	by	ADP
gs-4060	50	6	an	an	DET
gs-4060	50	7	aging	age	VERB
gs-4060	50	8	population	population	NOUN
gs-4060	50	9	,	,	PUNCT
gs-4060	50	10	increased	increase	VERB
gs-4060	50	11	prevalence	prevalence	NOUN
gs-4060	50	12	of	of	ADP
gs-4060	50	13	risk	risk	NOUN
gs-4060	50	14	factors	factor	NOUN
gs-4060	50	15	such	such	ADJ
gs-4060	50	16	as	as	ADP
gs-4060	50	17	smoking	smoking	NOUN
gs-4060	50	18	and	and	CCONJ
gs-4060	50	19	obesity	obesity	NOUN
gs-4060	50	20	,	,	PUNCT
gs-4060	50	21	and	and	CCONJ
gs-4060	50	22	environmental	environmental	ADJ
gs-4060	50	23	exposures	exposure	NOUN
gs-4060	50	24	including	include	VERB
gs-4060	50	25	air	air	NOUN
gs-4060	50	26	pollution	pollution	NOUN
gs-4060	50	27	and	and	CCONJ
gs-4060	50	28	occupational	occupational	ADJ
gs-4060	50	29	carcinogens	carcinogen	NOUN
gs-4060	50	30	.	.	PUNCT
gs-4060	51	1	the	the	DET
gs-4060	51	2	complexity	complexity	NOUN
gs-4060	51	3	of	of	ADP
gs-4060	51	4	cancer	cancer	NOUN
gs-4060	51	5	,	,	PUNCT
gs-4060	51	6	characterized	characterize	VERB
gs-4060	51	7	by	by	ADP
gs-4060	51	8	uncontrolled	uncontrolled	ADJ
gs-4060	51	9	georgian	georgian	NOUN
gs-4060	51	10	scientists/	scientists/	NUM
gs-4060	51	11	.	.	PUNCT
gs-4060	52	1	7	7	NUM
gs-4060	52	2	n	n	PRON
gs-4060	52	3	3	3	NUM
gs-4060	52	4	,	,	PUNCT
gs-4060	52	5	2025	2025	NUM
gs-4060	52	6	573	573	NUM
gs-4060	52	7	cell	cell	NOUN
gs-4060	52	8	growth	growth	NOUN
gs-4060	52	9	,	,	PUNCT
gs-4060	52	10	genetic	genetic	ADJ
gs-4060	52	11	heterogeneity	heterogeneity	NOUN
gs-4060	52	12	,	,	PUNCT
gs-4060	52	13	and	and	CCONJ
gs-4060	52	14	metastatic	metastatic	ADJ
gs-4060	52	15	potential	potential	NOUN
gs-4060	52	16	,	,	PUNCT
gs-4060	52	17	necessitates	necessitate	VERB
gs-4060	52	18	innovative	innovative	ADJ
gs-4060	52	19	therapeutic	therapeutic	ADJ
gs-4060	52	20	strategies	strategy	NOUN
gs-4060	52	21	.	.	PUNCT
gs-4060	53	1	over	over	ADP
gs-4060	53	2	the	the	DET
gs-4060	53	3	past	past	ADJ
gs-4060	53	4	few	few	ADJ
gs-4060	53	5	decades	decade	NOUN
gs-4060	53	6	,	,	PUNCT
gs-4060	53	7	anticancer	anticancer	NOUN
gs-4060	53	8	drug	drug	NOUN
gs-4060	53	9	development	development	NOUN
gs-4060	53	10	has	have	AUX
gs-4060	53	11	transitioned	transition	VERB
gs-4060	53	12	from	from	ADP
gs-4060	53	13	nonspecific	nonspecific	ADJ
gs-4060	53	14	cytotoxic	cytotoxic	ADJ
gs-4060	53	15	agents	agent	NOUN
gs-4060	53	16	to	to	ADP
gs-4060	53	17	highly	highly	ADV
gs-4060	53	18	targeted	target	VERB
gs-4060	53	19	therapies	therapy	NOUN
gs-4060	53	20	,	,	PUNCT
gs-4060	53	21	immunotherapies	immunotherapy	NOUN
gs-4060	53	22	,	,	PUNCT
gs-4060	53	23	and	and	CCONJ
gs-4060	53	24	advanced	advanced	ADJ
gs-4060	53	25	drug	drug	NOUN
gs-4060	53	26	delivery	delivery	NOUN
gs-4060	53	27	systems	system	NOUN
gs-4060	53	28	,	,	PUNCT
gs-4060	53	29	revolutionizing	revolutionize	VERB
gs-4060	53	30	clinical	clinical	ADJ
gs-4060	53	31	management	management	NOUN
gs-4060	53	32	and	and	CCONJ
gs-4060	53	33	patient	patient	ADJ
gs-4060	53	34	outcomes	outcome	NOUN
gs-4060	53	35	.	.	PUNCT
gs-4060	54	1	historically	historically	ADV
gs-4060	54	2	,	,	PUNCT
gs-4060	54	3	the	the	DET
gs-4060	54	4	fight	fight	NOUN
gs-4060	54	5	against	against	ADP
gs-4060	54	6	cancer	cancer	NOUN
gs-4060	54	7	began	begin	VERB
gs-4060	54	8	with	with	ADP
gs-4060	54	9	rudimentary	rudimentary	ADJ
gs-4060	54	10	interventions	intervention	NOUN
gs-4060	54	11	.	.	PUNCT
gs-4060	55	1	in	in	ADP
gs-4060	55	2	the	the	DET
gs-4060	55	3	19th	19th	ADJ
gs-4060	55	4	century	century	NOUN
gs-4060	55	5	,	,	PUNCT
gs-4060	55	6	natural	natural	ADJ
gs-4060	55	7	compounds	compound	NOUN
gs-4060	55	8	like	like	ADP
gs-4060	55	9	podophyllotoxin	podophyllotoxin	NOUN
gs-4060	55	10	from	from	ADP
gs-4060	55	11	podophyllum	podophyllum	PROPN
gs-4060	55	12	peltatum	peltatum	NOUN
gs-4060	55	13	laid	lay	VERB
gs-4060	55	14	the	the	DET
gs-4060	55	15	groundwork	groundwork	NOUN
gs-4060	55	16	for	for	ADP
gs-4060	55	17	modern	modern	ADJ
gs-4060	55	18	chemotherapeutics	chemotherapeutic	NOUN
gs-4060	55	19	such	such	ADJ
gs-4060	55	20	as	as	ADP
gs-4060	55	21	etoposide	etoposide	NOUN
gs-4060	55	22	,	,	PUNCT
gs-4060	55	23	approved	approve	VERB
gs-4060	55	24	in	in	ADP
gs-4060	55	25	1983	1983	NUM
gs-4060	55	26	.	.	PUNCT
gs-4060	56	1	the	the	DET
gs-4060	56	2	mid-20th	mid-20th	NUM
gs-4060	56	3	century	century	NOUN
gs-4060	56	4	saw	see	VERB
gs-4060	56	5	significant	significant	ADJ
gs-4060	56	6	milestones	milestone	NOUN
gs-4060	56	7	with	with	ADP
gs-4060	56	8	the	the	DET
gs-4060	56	9	discovery	discovery	NOUN
gs-4060	56	10	of	of	ADP
gs-4060	56	11	nitrogen	nitrogen	NOUN
gs-4060	56	12	mustards	mustard	NOUN
gs-4060	56	13	during	during	ADP
gs-4060	56	14	world	world	PROPN
gs-4060	56	15	war	war	PROPN
gs-4060	56	16	ii	ii	PROPN
gs-4060	56	17	,	,	PUNCT
gs-4060	56	18	leading	lead	VERB
gs-4060	56	19	to	to	ADP
gs-4060	56	20	alkylating	alkylate	VERB
gs-4060	56	21	agents	agent	NOUN
gs-4060	56	22	like	like	ADP
gs-4060	56	23	cyclophosphamide	cyclophosphamide	NOUN
gs-4060	56	24	.	.	PUNCT
gs-4060	57	1	concurrently	concurrently	ADV
gs-4060	57	2	,	,	PUNCT
gs-4060	57	3	antifolates	antifolate	VERB
gs-4060	57	4	such	such	ADJ
gs-4060	57	5	as	as	ADP
gs-4060	57	6	methotrexate	methotrexate	NOUN
gs-4060	57	7	(	(	PUNCT
gs-4060	57	8	approved	approve	VERB
gs-4060	57	9	in	in	ADP
gs-4060	57	10	1948	1948	NUM
gs-4060	57	11	)	)	PUNCT
gs-4060	57	12	and	and	CCONJ
gs-4060	57	13	antimetabolites	antimetabolite	NOUN
gs-4060	57	14	like	like	ADP
gs-4060	57	15	5	5	NUM
gs-4060	57	16	-	-	PUNCT
gs-4060	57	17	fluorouracil	fluorouracil	NOUN
gs-4060	57	18	(	(	PUNCT
gs-4060	57	19	1950s	1950s	NUM
gs-4060	57	20	)	)	PUNCT
gs-4060	57	21	emerged	emerge	VERB
gs-4060	57	22	,	,	PUNCT
gs-4060	57	23	targeting	target	VERB
gs-4060	57	24	dna	dna	NOUN
gs-4060	57	25	and	and	CCONJ
gs-4060	57	26	rna	rna	NOUN
gs-4060	57	27	synthesis	synthesis	NOUN
gs-4060	57	28	.	.	PUNCT
gs-4060	58	1	plant	plant	NOUN
gs-4060	58	2	-	-	PUNCT
gs-4060	58	3	derived	derive	VERB
gs-4060	58	4	agents	agent	NOUN
gs-4060	58	5	,	,	PUNCT
gs-4060	58	6	including	include	VERB
gs-4060	58	7	vinblastine	vinblastine	NOUN
gs-4060	58	8	in	in	ADP
gs-4060	58	9	the	the	DET
gs-4060	58	10	1960s	1960	NOUN
gs-4060	58	11	and	and	CCONJ
gs-4060	58	12	paclitaxel	paclitaxel	PROPN
gs-4060	58	13	in	in	ADP
gs-4060	58	14	the	the	DET
gs-4060	58	15	1990s	1990	NOUN
gs-4060	58	16	,	,	PUNCT
gs-4060	58	17	further	far	ADV
gs-4060	58	18	expanded	expand	VERB
gs-4060	58	19	the	the	DET
gs-4060	58	20	chemotherapeutic	chemotherapeutic	ADJ
gs-4060	58	21	arsenal	arsenal	NOUN
gs-4060	58	22	.	.	PUNCT
gs-4060	59	1	the	the	DET
gs-4060	59	2	serendipitous	serendipitous	ADJ
gs-4060	59	3	discovery	discovery	NOUN
gs-4060	59	4	of	of	ADP
gs-4060	59	5	cisplatin	cisplatin	NOUN
gs-4060	59	6	in	in	ADP
gs-4060	59	7	1965	1965	NUM
gs-4060	59	8	marked	mark	VERB
gs-4060	59	9	a	a	DET
gs-4060	59	10	pivotal	pivotal	ADJ
gs-4060	59	11	advancement	advancement	NOUN
gs-4060	59	12	,	,	PUNCT
gs-4060	59	13	introducing	introduce	VERB
gs-4060	59	14	platinum	platinum	NOUN
gs-4060	59	15	-	-	PUNCT
gs-4060	59	16	based	base	VERB
gs-4060	59	17	drugs	drug	NOUN
gs-4060	59	18	that	that	PRON
gs-4060	59	19	remain	remain	VERB
gs-4060	59	20	cornerstones	cornerstone	NOUN
gs-4060	59	21	in	in	ADP
gs-4060	59	22	treating	treat	VERB
gs-4060	59	23	solid	solid	ADJ
gs-4060	59	24	tumors	tumor	NOUN
gs-4060	59	25	.	.	PUNCT
gs-4060	60	1	the	the	DET
gs-4060	60	2	late	late	ADJ
gs-4060	60	3	1990s	1990	NOUN
gs-4060	60	4	ushered	usher	VERB
gs-4060	60	5	in	in	ADP
gs-4060	60	6	a	a	DET
gs-4060	60	7	paradigm	paradigm	NOUN
gs-4060	60	8	shift	shift	NOUN
gs-4060	60	9	with	with	ADP
gs-4060	60	10	the	the	DET
gs-4060	60	11	advent	advent	NOUN
gs-4060	60	12	of	of	ADP
gs-4060	60	13	targeted	target	VERB
gs-4060	60	14	therapies	therapy	NOUN
gs-4060	60	15	.	.	PUNCT
gs-4060	61	1	the	the	DET
gs-4060	61	2	approval	approval	NOUN
gs-4060	61	3	of	of	ADP
gs-4060	61	4	trastuzumab	trastuzumab	NOUN
gs-4060	61	5	in	in	ADP
gs-4060	61	6	1998	1998	NUM
gs-4060	61	7	for	for	ADP
gs-4060	61	8	her2	her2	NOUN
gs-4060	61	9	-	-	PUNCT
gs-4060	61	10	positive	positive	ADJ
gs-4060	61	11	breast	breast	NOUN
gs-4060	61	12	cancer	cancer	NOUN
gs-4060	61	13	and	and	CCONJ
gs-4060	61	14	imatinib	imatinib	NOUN
gs-4060	61	15	in	in	ADP
gs-4060	61	16	2001	2001	NUM
gs-4060	61	17	for	for	ADP
gs-4060	61	18	chronic	chronic	ADJ
gs-4060	61	19	myelogenous	myelogenous	ADJ
gs-4060	61	20	leukemia	leukemia	NOUN
gs-4060	61	21	(	(	PUNCT
gs-4060	61	22	cml	cml	PROPN
gs-4060	61	23	)	)	PUNCT
gs-4060	61	24	exemplified	exemplify	VERB
gs-4060	61	25	the	the	DET
gs-4060	61	26	potential	potential	NOUN
gs-4060	61	27	of	of	ADP
gs-4060	61	28	precision	precision	NOUN
gs-4060	61	29	medicine	medicine	NOUN
gs-4060	61	30	,	,	PUNCT
gs-4060	61	31	targeting	target	VERB
gs-4060	61	32	specific	specific	ADJ
gs-4060	61	33	molecular	molecular	ADJ
gs-4060	61	34	aberrations	aberration	NOUN
gs-4060	61	35	.	.	PUNCT
gs-4060	62	1	these	these	DET
gs-4060	62	2	successes	success	NOUN
gs-4060	62	3	spurred	spur	VERB
gs-4060	62	4	the	the	DET
gs-4060	62	5	development	development	NOUN
gs-4060	62	6	of	of	ADP
gs-4060	62	7	tyrosine	tyrosine	PROPN
gs-4060	62	8	kinase	kinase	PROPN
gs-4060	62	9	inhibitors	inhibitor	NOUN
gs-4060	62	10	(	(	PUNCT
gs-4060	62	11	tkis	tkis	NOUN
gs-4060	62	12	)	)	PUNCT
gs-4060	62	13	,	,	PUNCT
gs-4060	62	14	monoclonal	monoclonal	NOUN
gs-4060	62	15	antibodies	antibodie	VERB
gs-4060	62	16	,	,	PUNCT
gs-4060	62	17	and	and	CCONJ
gs-4060	62	18	other	other	ADJ
gs-4060	62	19	biologics	biologic	NOUN
gs-4060	62	20	.	.	PUNCT
gs-4060	63	1	by	by	ADP
gs-4060	63	2	2025	2025	NUM
gs-4060	63	3	,	,	PUNCT
gs-4060	63	4	the	the	DET
gs-4060	63	5	therapeutic	therapeutic	ADJ
gs-4060	63	6	landscape	landscape	NOUN
gs-4060	63	7	has	have	AUX
gs-4060	63	8	further	far	ADV
gs-4060	63	9	evolved	evolve	VERB
gs-4060	63	10	with	with	ADP
gs-4060	63	11	the	the	DET
gs-4060	63	12	introduction	introduction	NOUN
gs-4060	63	13	of	of	ADP
gs-4060	63	14	antibody	antibody	NOUN
gs-4060	63	15	-	-	PUNCT
gs-4060	63	16	drug	drug	NOUN
gs-4060	63	17	conjugates	conjugate	NOUN
gs-4060	63	18	(	(	PUNCT
gs-4060	63	19	adcs	adcs	ADJ
gs-4060	63	20	)	)	PUNCT
gs-4060	63	21	,	,	PUNCT
gs-4060	63	22	immune	immune	ADJ
gs-4060	63	23	checkpoint	checkpoint	NOUN
gs-4060	63	24	inhibitors	inhibitor	NOUN
gs-4060	63	25	,	,	PUNCT
gs-4060	63	26	and	and	CCONJ
gs-4060	63	27	chimeric	chimeric	ADJ
gs-4060	63	28	antigen	antigen	ADJ
gs-4060	63	29	receptor	receptor	NOUN
gs-4060	63	30	t	t	NOUN
gs-4060	63	31	-	-	PUNCT
gs-4060	63	32	cell	cell	NOUN
gs-4060	63	33	(	(	PUNCT
gs-4060	63	34	car	car	NOUN
gs-4060	63	35	-	-	PUNCT
gs-4060	63	36	t	t	NOUN
gs-4060	63	37	)	)	PUNCT
gs-4060	63	38	therapies	therapy	NOUN
gs-4060	63	39	,	,	PUNCT
gs-4060	63	40	alongside	alongside	ADP
gs-4060	63	41	novel	novel	ADJ
gs-4060	63	42	approaches	approach	NOUN
gs-4060	63	43	like	like	ADP
gs-4060	63	44	nanotechnology	nanotechnology	NOUN
gs-4060	63	45	and	and	CCONJ
gs-4060	63	46	drug	drug	NOUN
gs-4060	63	47	repurposing	repurposing	NOUN
gs-4060	63	48	.	.	PUNCT
gs-4060	64	1	these	these	DET
gs-4060	64	2	advancements	advancement	NOUN
gs-4060	64	3	aim	aim	VERB
gs-4060	64	4	to	to	PART
gs-4060	64	5	enhance	enhance	VERB
gs-4060	64	6	efficacy	efficacy	NOUN
gs-4060	64	7	,	,	PUNCT
gs-4060	64	8	minimize	minimize	VERB
gs-4060	64	9	offtarget	offtarget	NOUN
gs-4060	64	10	effects	effect	NOUN
gs-4060	64	11	,	,	PUNCT
gs-4060	64	12	and	and	CCONJ
gs-4060	64	13	overcome	overcome	VERB
gs-4060	64	14	resistance	resistance	NOUN
gs-4060	64	15	,	,	PUNCT
gs-4060	64	16	a	a	DET
gs-4060	64	17	persistent	persistent	ADJ
gs-4060	64	18	challenge	challenge	NOUN
gs-4060	64	19	in	in	ADP
gs-4060	64	20	oncology	oncology	NOUN
gs-4060	64	21	.	.	PUNCT
gs-4060	65	1	this	this	DET
gs-4060	65	2	article	article	NOUN
gs-4060	65	3	comprehensively	comprehensively	ADV
gs-4060	65	4	examines	examine	VERB
gs-4060	65	5	the	the	DET
gs-4060	65	6	scientific	scientific	ADJ
gs-4060	65	7	aspects	aspect	NOUN
gs-4060	65	8	of	of	ADP
gs-4060	65	9	new	new	ADJ
gs-4060	65	10	anticancer	anticancer	NOUN
gs-4060	65	11	drugs	drug	NOUN
gs-4060	65	12	,	,	PUNCT
gs-4060	65	13	focusing	focus	VERB
gs-4060	65	14	on	on	ADP
gs-4060	65	15	their	their	PRON
gs-4060	65	16	classification	classification	NOUN
gs-4060	65	17	,	,	PUNCT
gs-4060	65	18	clinical	clinical	ADJ
gs-4060	65	19	use	use	NOUN
gs-4060	65	20	,	,	PUNCT
gs-4060	65	21	features	feature	NOUN
gs-4060	65	22	and	and	CCONJ
gs-4060	65	23	mechanisms	mechanism	NOUN
gs-4060	65	24	of	of	ADP
gs-4060	65	25	action	action	NOUN
gs-4060	65	26	,	,	PUNCT
gs-4060	65	27	pharmacology	pharmacology	NOUN
gs-4060	65	28	,	,	PUNCT
gs-4060	65	29	therapeutic	therapeutic	ADJ
gs-4060	65	30	effects	effect	NOUN
gs-4060	65	31	,	,	PUNCT
gs-4060	65	32	and	and	CCONJ
gs-4060	65	33	toxicities	toxicity	NOUN
gs-4060	65	34	.	.	PUNCT
gs-4060	66	1	the	the	DET
gs-4060	66	2	scope	scope	NOUN
gs-4060	66	3	is	be	AUX
gs-4060	66	4	limited	limit	VERB
gs-4060	66	5	to	to	ADP
gs-4060	66	6	drugs	drug	NOUN
gs-4060	66	7	with	with	ADP
gs-4060	66	8	full	full	ADJ
gs-4060	66	9	approval	approval	NOUN
gs-4060	66	10	by	by	ADP
gs-4060	66	11	the	the	DET
gs-4060	66	12	u.s	u.s	PROPN
gs-4060	66	13	.	.	PROPN
gs-4060	66	14	food	food	PROPN
gs-4060	66	15	and	and	CCONJ
gs-4060	66	16	drug	drug	PROPN
gs-4060	66	17	administration	administration	PROPN
gs-4060	66	18	(	(	PUNCT
gs-4060	66	19	fda	fda	PROPN
gs-4060	66	20	)	)	PUNCT
gs-4060	66	21	and	and	CCONJ
gs-4060	66	22	european	european	ADJ
gs-4060	66	23	medicines	medicine	NOUN
gs-4060	66	24	agency	agency	NOUN
gs-4060	66	25	(	(	PUNCT
gs-4060	66	26	ema	ema	PROPN
gs-4060	66	27	)	)	PUNCT
gs-4060	66	28	as	as	ADP
gs-4060	66	29	of	of	ADP
gs-4060	66	30	march	march	PROPN
gs-4060	66	31	2024	2024	NUM
gs-4060	66	32	,	,	PUNCT
gs-4060	66	33	excluding	exclude	VERB
gs-4060	66	34	those	those	PRON
gs-4060	66	35	under	under	ADP
gs-4060	66	36	accelerated	accelerated	ADJ
gs-4060	66	37	or	or	CCONJ
gs-4060	66	38	conditional	conditional	ADJ
gs-4060	66	39	approval	approval	NOUN
gs-4060	66	40	to	to	PART
gs-4060	66	41	ensure	ensure	VERB
gs-4060	66	42	robust	robust	ADJ
gs-4060	66	43	evidence	evidence	NOUN
gs-4060	66	44	of	of	ADP
gs-4060	66	45	clinical	clinical	ADJ
gs-4060	66	46	benefit	benefit	NOUN
gs-4060	66	47	.	.	PUNCT
gs-4060	67	1	the	the	DET
gs-4060	67	2	classification	classification	NOUN
gs-4060	67	3	framework	framework	NOUN
gs-4060	67	4	organizes	organize	VERB
gs-4060	67	5	drugs	drug	NOUN
gs-4060	67	6	by	by	ADP
gs-4060	67	7	their	their	PRON
gs-4060	67	8	site	site	NOUN
gs-4060	67	9	of	of	ADP
gs-4060	67	10	action	action	NOUN
gs-4060	67	11	—	—	PUNCT
gs-4060	67	12	tumor	tumor	NOUN
gs-4060	67	13	cell	cell	NOUN
gs-4060	67	14	nucleus	nucleus	NOUN
gs-4060	67	15	,	,	PUNCT
gs-4060	67	16	cytoplasm	cytoplasm	ADJ
gs-4060	67	17	,	,	PUNCT
gs-4060	67	18	vasculature	vasculature	NOUN
gs-4060	67	19	,	,	PUNCT
gs-4060	67	20	immune	immune	ADJ
gs-4060	67	21	system	system	NOUN
gs-4060	67	22	,	,	PUNCT
gs-4060	67	23	or	or	CCONJ
gs-4060	67	24	endocrine	endocrine	ADJ
gs-4060	67	25	system	system	NOUN
gs-4060	67	26	—	—	PUNCT
gs-4060	67	27	and	and	CCONJ
gs-4060	67	28	their	their	PRON
gs-4060	67	29	mechanistic	mechanistic	ADJ
gs-4060	67	30	approach	approach	NOUN
gs-4060	67	31	,	,	PUNCT
gs-4060	67	32	providing	provide	VERB
gs-4060	67	33	a	a	DET
gs-4060	67	34	structured	structured	ADJ
gs-4060	67	35	understanding	understanding	NOUN
gs-4060	67	36	of	of	ADP
gs-4060	67	37	their	their	PRON
gs-4060	67	38	therapeutic	therapeutic	ADJ
gs-4060	67	39	roles	role	NOUN
gs-4060	67	40	.	.	PUNCT
gs-4060	68	1	this	this	DET
gs-4060	68	2	system	system	NOUN
gs-4060	68	3	facilitates	facilitate	VERB
gs-4060	68	4	the	the	DET
gs-4060	68	5	design	design	NOUN
gs-4060	68	6	of	of	ADP
gs-4060	68	7	rational	rational	ADJ
gs-4060	68	8	combination	combination	NOUN
gs-4060	68	9	therapies	therapy	NOUN
gs-4060	68	10	and	and	CCONJ
gs-4060	68	11	highlights	highlight	NOUN
gs-4060	68	12	synergistic	synergistic	ADJ
gs-4060	68	13	potential	potential	NOUN
gs-4060	68	14	.	.	PUNCT
gs-4060	69	1	the	the	DET
gs-4060	69	2	field	field	NOUN
gs-4060	69	3	of	of	ADP
gs-4060	69	4	oncology	oncology	NOUN
gs-4060	69	5	stands	stand	VERB
gs-4060	69	6	at	at	ADP
gs-4060	69	7	a	a	DET
gs-4060	69	8	pivotal	pivotal	ADJ
gs-4060	69	9	juncture	juncture	NOUN
gs-4060	69	10	,	,	PUNCT
gs-4060	69	11	characterized	characterize	VERB
gs-4060	69	12	by	by	ADP
gs-4060	69	13	a	a	DET
gs-4060	69	14	profound	profound	ADJ
gs-4060	69	15	transformation	transformation	NOUN
gs-4060	69	16	from	from	ADP
gs-4060	69	17	a	a	DET
gs-4060	69	18	one	one	NUM
gs-4060	69	19	-	-	PUNCT
gs-4060	69	20	size	size	NOUN
gs-4060	69	21	-	-	PUNCT
gs-4060	69	22	fits	fit	VERB
gs-4060	69	23	-	-	PUNCT
gs-4060	69	24	all	all	PRON
gs-4060	69	25	approach	approach	NOUN
gs-4060	69	26	to	to	ADP
gs-4060	69	27	a	a	DET
gs-4060	69	28	nuanced	nuanced	ADJ
gs-4060	69	29	era	era	NOUN
gs-4060	69	30	of	of	ADP
gs-4060	69	31	precision	precision	NOUN
gs-4060	69	32	medicine	medicine	NOUN
gs-4060	69	33	.	.	PUNCT
gs-4060	70	1	for	for	ADP
gs-4060	70	2	decades	decade	NOUN
gs-4060	70	3	,	,	PUNCT
gs-4060	70	4	the	the	DET
gs-4060	70	5	arsenal	arsenal	NOUN
gs-4060	70	6	against	against	ADP
gs-4060	70	7	cancer	cancer	NOUN
gs-4060	70	8	was	be	AUX
gs-4060	70	9	dominated	dominate	VERB
gs-4060	70	10	by	by	ADP
gs-4060	70	11	conventional	conventional	ADJ
gs-4060	70	12	cytotoxic	cytotoxic	ADJ
gs-4060	70	13	chemotherapy	chemotherapy	NOUN
gs-4060	70	14	and	and	CCONJ
gs-4060	70	15	radiotherapy	radiotherapy	NOUN
gs-4060	70	16	.	.	PUNCT
gs-4060	71	1	these	these	DET
gs-4060	71	2	modalities	modality	NOUN
gs-4060	71	3	,	,	PUNCT
gs-4060	71	4	while	while	SCONJ
gs-4060	71	5	sometimes	sometimes	ADV
gs-4060	71	6	effective	effective	ADJ
gs-4060	71	7	,	,	PUNCT
gs-4060	71	8	operate	operate	VERB
gs-4060	71	9	on	on	ADP
gs-4060	71	10	a	a	DET
gs-4060	71	11	fundamental	fundamental	ADJ
gs-4060	71	12	principle	principle	NOUN
gs-4060	71	13	of	of	ADP
gs-4060	71	14	targeting	target	VERB
gs-4060	71	15	rapidly	rapidly	ADV
gs-4060	71	16	dividing	divide	VERB
gs-4060	71	17	cells	cell	NOUN
gs-4060	71	18	,	,	PUNCT
gs-4060	71	19	a	a	DET
gs-4060	71	20	characteristic	characteristic	NOUN
gs-4060	71	21	of	of	ADP
gs-4060	71	22	cancer	cancer	NOUN
gs-4060	71	23	cells	cell	NOUN
gs-4060	71	24	but	but	CCONJ
gs-4060	71	25	also	also	ADV
gs-4060	71	26	of	of	ADP
gs-4060	71	27	healthy	healthy	ADJ
gs-4060	71	28	tissues	tissue	NOUN
gs-4060	71	29	such	such	ADJ
gs-4060	71	30	as	as	ADP
gs-4060	71	31	those	those	PRON
gs-4060	71	32	in	in	ADP
gs-4060	71	33	the	the	DET
gs-4060	71	34	bone	bone	NOUN
gs-4060	71	35	marrow	marrow	NOUN
gs-4060	71	36	,	,	PUNCT
gs-4060	71	37	gastrointestinal	gastrointestinal	ADJ
gs-4060	71	38	tract	tract	NOUN
gs-4060	71	39	,	,	PUNCT
gs-4060	71	40	and	and	CCONJ
gs-4060	71	41	hair	hair	NOUN
gs-4060	71	42	follicles	follicle	NOUN
gs-4060	71	43	.	.	PUNCT
gs-4060	72	1	this	this	DET
gs-4060	72	2	lack	lack	NOUN
gs-4060	72	3	of	of	ADP
gs-4060	72	4	selectivity	selectivity	NOUN
gs-4060	72	5	is	be	AUX
gs-4060	72	6	the	the	DET
gs-4060	72	7	primary	primary	ADJ
gs-4060	72	8	source	source	NOUN
gs-4060	72	9	of	of	ADP
gs-4060	72	10	their	their	PRON
gs-4060	72	11	severe	severe	ADJ
gs-4060	72	12	and	and	CCONJ
gs-4060	72	13	often	often	ADV
gs-4060	72	14	debilitating	debilitate	VERB
gs-4060	72	15	side	side	NOUN
gs-4060	72	16	effects	effect	NOUN
gs-4060	72	17	,	,	PUNCT
gs-4060	72	18	which	which	PRON
gs-4060	72	19	include	include	VERB
gs-4060	72	20	myelosuppression	myelosuppression	NOUN
gs-4060	72	21	,	,	PUNCT
gs-4060	72	22	mucositis	mucositis	NOUN
gs-4060	72	23	,	,	PUNCT
gs-4060	72	24	and	and	CCONJ
gs-4060	72	25	alopecia	alopecia	NOUN
gs-4060	72	26	,	,	PUNCT
gs-4060	72	27	thereby	thereby	ADV
gs-4060	72	28	limiting	limit	VERB
gs-4060	72	29	their	their	PRON
gs-4060	72	30	therapeutic	therapeutic	ADJ
gs-4060	72	31	window	window	NOUN
gs-4060	72	32	and	and	CCONJ
gs-4060	72	33	often	often	ADV
gs-4060	72	34	compromising	compromise	VERB
gs-4060	72	35	the	the	DET
gs-4060	72	36	patient	patient	NOUN
gs-4060	72	37	's	's	PART
gs-4060	72	38	quality	quality	NOUN
gs-4060	72	39	of	of	ADP
gs-4060	72	40	life	life	NOUN
gs-4060	72	41	.	.	PUNCT
gs-4060	73	1	moreover	moreover	ADV
gs-4060	73	2	,	,	PUNCT
gs-4060	73	3	the	the	DET
gs-4060	73	4	efficacy	efficacy	NOUN
gs-4060	73	5	of	of	ADP
gs-4060	73	6	these	these	DET
gs-4060	73	7	treatments	treatment	NOUN
gs-4060	73	8	frequently	frequently	ADV
gs-4060	73	9	plateaus	plateaus	VERB
gs-4060	73	10	,	,	PUNCT
gs-4060	73	11	with	with	ADP
gs-4060	73	12	many	many	ADJ
gs-4060	73	13	cancers	cancer	NOUN
gs-4060	73	14	developing	develop	VERB
gs-4060	73	15	resistance	resistance	NOUN
gs-4060	73	16	or	or	CCONJ
gs-4060	73	17	recurring	recurring	NOUN
gs-4060	73	18	after	after	ADP
gs-4060	73	19	an	an	DET
gs-4060	73	20	initial	initial	ADJ
gs-4060	73	21	response	response	NOUN
gs-4060	73	22	,	,	PUNCT
gs-4060	73	23	highlighting	highlight	VERB
gs-4060	73	24	an	an	DET
gs-4060	73	25	urgent	urgent	ADJ
gs-4060	73	26	and	and	CCONJ
gs-4060	73	27	unmet	unmet	NOUN
gs-4060	73	28	need	need	VERB
gs-4060	73	29	for	for	ADP
gs-4060	73	30	more	more	ADV
gs-4060	73	31	sophisticated	sophisticated	ADJ
gs-4060	73	32	and	and	CCONJ
gs-4060	73	33	targeted	target	VERB
gs-4060	73	34	therapeutic	therapeutic	ADJ
gs-4060	73	35	strategies	strategy	NOUN
gs-4060	73	36	.	.	PUNCT
gs-4060	74	1	georgian	georgian	NOUN
gs-4060	74	2	scientists/	scientists/	NUM
gs-4060	74	3	.	.	PUNCT
gs-4060	75	1	7	7	NUM
gs-4060	75	2	n	n	PRON
gs-4060	75	3	3	3	NUM
gs-4060	75	4	,	,	PUNCT
gs-4060	75	5	2025	2025	NUM
gs-4060	75	6	574	574	NUM
gs-4060	76	1	this	this	DET
gs-4060	76	2	paradigm	paradigm	NOUN
gs-4060	76	3	shift	shift	NOUN
gs-4060	76	4	has	have	AUX
gs-4060	76	5	been	be	AUX
gs-4060	76	6	catalyzed	catalyze	VERB
gs-4060	76	7	by	by	ADP
gs-4060	76	8	the	the	DET
gs-4060	76	9	monumental	monumental	ADJ
gs-4060	76	10	advances	advance	NOUN
gs-4060	76	11	in	in	ADP
gs-4060	76	12	our	our	PRON
gs-4060	76	13	understanding	understanding	NOUN
gs-4060	76	14	of	of	ADP
gs-4060	76	15	the	the	DET
gs-4060	76	16	molecular	molecular	ADJ
gs-4060	76	17	and	and	CCONJ
gs-4060	76	18	genetic	genetic	ADJ
gs-4060	76	19	underpinnings	underpinning	NOUN
gs-4060	76	20	of	of	ADP
gs-4060	76	21	carcinogenesis	carcinogenesis	NOUN
gs-4060	76	22	.	.	PUNCT
gs-4060	77	1	the	the	DET
gs-4060	77	2	completion	completion	NOUN
gs-4060	77	3	of	of	ADP
gs-4060	77	4	the	the	DET
gs-4060	77	5	human	human	ADJ
gs-4060	77	6	genome	genome	NOUN
gs-4060	77	7	project	project	NOUN
gs-4060	77	8	and	and	CCONJ
gs-4060	77	9	subsequent	subsequent	ADJ
gs-4060	77	10	large	large	ADJ
gs-4060	77	11	-	-	PUNCT
gs-4060	77	12	scale	scale	NOUN
gs-4060	77	13	cancer	cancer	NOUN
gs-4060	77	14	genomics	genomic	NOUN
gs-4060	77	15	initiatives	initiative	NOUN
gs-4060	77	16	,	,	PUNCT
gs-4060	77	17	such	such	ADJ
gs-4060	77	18	as	as	ADP
gs-4060	77	19	the	the	DET
gs-4060	77	20	cancer	cancer	NOUN
gs-4060	77	21	genome	genome	NOUN
gs-4060	77	22	atlas	atlas	PROPN
gs-4060	77	23	(	(	PUNCT
gs-4060	77	24	tcga	tcga	PROPN
gs-4060	77	25	)	)	PUNCT
gs-4060	77	26	,	,	PUNCT
gs-4060	77	27	have	have	AUX
gs-4060	77	28	illuminated	illuminate	VERB
gs-4060	77	29	the	the	DET
gs-4060	77	30	complex	complex	ADJ
gs-4060	77	31	landscape	landscape	NOUN
gs-4060	77	32	of	of	ADP
gs-4060	77	33	driver	driver	NOUN
gs-4060	77	34	mutations	mutation	NOUN
gs-4060	77	35	,	,	PUNCT
gs-4060	77	36	aberrant	aberrant	ADJ
gs-4060	77	37	signaling	signal	VERB
gs-4060	77	38	pathways	pathway	NOUN
gs-4060	77	39	,	,	PUNCT
gs-4060	77	40	and	and	CCONJ
gs-4060	77	41	intricate	intricate	ADJ
gs-4060	77	42	interactions	interaction	NOUN
gs-4060	77	43	between	between	ADP
gs-4060	77	44	tumor	tumor	NOUN
gs-4060	77	45	cells	cell	NOUN
gs-4060	77	46	and	and	CCONJ
gs-4060	77	47	their	their	PRON
gs-4060	77	48	microenvironment	microenvironment	NOUN
gs-4060	77	49	.	.	PUNCT
gs-4060	78	1	we	we	PRON
gs-4060	78	2	now	now	ADV
gs-4060	78	3	comprehend	comprehend	VERB
gs-4060	78	4	cancer	cancer	NOUN
gs-4060	78	5	not	not	PART
gs-4060	78	6	as	as	ADP
gs-4060	78	7	a	a	DET
gs-4060	78	8	single	single	ADJ
gs-4060	78	9	disease	disease	NOUN
gs-4060	78	10	,	,	PUNCT
gs-4060	78	11	but	but	CCONJ
gs-4060	78	12	as	as	ADP
gs-4060	78	13	a	a	DET
gs-4060	78	14	heterogeneous	heterogeneous	ADJ
gs-4060	78	15	collection	collection	NOUN
gs-4060	78	16	of	of	ADP
gs-4060	78	17	disorders	disorder	NOUN
gs-4060	78	18	,	,	PUNCT
gs-4060	78	19	each	each	PRON
gs-4060	78	20	defined	define	VERB
gs-4060	78	21	by	by	ADP
gs-4060	78	22	its	its	PRON
gs-4060	78	23	unique	unique	ADJ
gs-4060	78	24	genetic	genetic	ADJ
gs-4060	78	25	signature	signature	NOUN
gs-4060	78	26	and	and	CCONJ
gs-4060	78	27	molecular	molecular	ADJ
gs-4060	78	28	profile	profile	NOUN
gs-4060	78	29	.	.	PUNCT
gs-4060	79	1	this	this	DET
gs-4060	79	2	deeper	deep	ADJ
gs-4060	79	3	knowledge	knowledge	NOUN
gs-4060	79	4	has	have	AUX
gs-4060	79	5	unveiled	unveil	VERB
gs-4060	79	6	specific	specific	ADJ
gs-4060	79	7	,	,	PUNCT
gs-4060	79	8	targetable	targetable	ADJ
gs-4060	79	9	vulnerabilities	vulnerability	NOUN
gs-4060	79	10	within	within	ADP
gs-4060	79	11	cancer	cancer	NOUN
gs-4060	79	12	cells	cell	NOUN
gs-4060	79	13	,	,	PUNCT
gs-4060	79	14	paving	pave	VERB
gs-4060	79	15	the	the	DET
gs-4060	79	16	way	way	NOUN
gs-4060	79	17	for	for	ADP
gs-4060	79	18	the	the	DET
gs-4060	79	19	rational	rational	ADJ
gs-4060	79	20	design	design	NOUN
gs-4060	79	21	and	and	CCONJ
gs-4060	79	22	development	development	NOUN
gs-4060	79	23	of	of	ADP
gs-4060	79	24	a	a	DET
gs-4060	79	25	new	new	ADJ
gs-4060	79	26	generation	generation	NOUN
gs-4060	79	27	of	of	ADP
gs-4060	79	28	anticancer	anticancer	NOUN
gs-4060	79	29	agents	agent	NOUN
gs-4060	79	30	.	.	PUNCT
gs-4060	80	1	these	these	DET
gs-4060	80	2	novel	novel	ADJ
gs-4060	80	3	drugs	drug	NOUN
gs-4060	80	4	are	be	AUX
gs-4060	80	5	engineered	engineer	VERB
gs-4060	80	6	to	to	PART
gs-4060	80	7	interfere	interfere	VERB
gs-4060	80	8	with	with	ADP
gs-4060	80	9	precise	precise	ADJ
gs-4060	80	10	molecular	molecular	ADJ
gs-4060	80	11	targets	target	NOUN
gs-4060	80	12	that	that	PRON
gs-4060	80	13	are	be	AUX
gs-4060	80	14	critically	critically	ADV
gs-4060	80	15	involved	involve	VERB
gs-4060	80	16	in	in	ADP
gs-4060	80	17	tumor	tumor	NOUN
gs-4060	80	18	growth	growth	NOUN
gs-4060	80	19	,	,	PUNCT
gs-4060	80	20	progression	progression	NOUN
gs-4060	80	21	,	,	PUNCT
gs-4060	80	22	and	and	CCONJ
gs-4060	80	23	survival	survival	NOUN
gs-4060	80	24	,	,	PUNCT
gs-4060	80	25	offering	offer	VERB
gs-4060	80	26	the	the	DET
gs-4060	80	27	promise	promise	NOUN
gs-4060	80	28	of	of	ADP
gs-4060	80	29	greater	great	ADJ
gs-4060	80	30	efficacy	efficacy	NOUN
gs-4060	80	31	coupled	couple	VERB
gs-4060	80	32	with	with	ADP
gs-4060	80	33	a	a	DET
gs-4060	80	34	more	more	ADV
gs-4060	80	35	favorable	favorable	ADJ
gs-4060	80	36	toxicity	toxicity	NOUN
gs-4060	80	37	profile	profile	NOUN
gs-4060	80	38	.	.	PUNCT
gs-4060	81	1	the	the	DET
gs-4060	81	2	emergence	emergence	NOUN
gs-4060	81	3	of	of	ADP
gs-4060	81	4	these	these	DET
gs-4060	81	5	new	new	ADJ
gs-4060	81	6	anticancer	anticancer	NOUN
gs-4060	81	7	drugs	drug	NOUN
gs-4060	81	8	represents	represent	VERB
gs-4060	81	9	a	a	DET
gs-4060	81	10	cornerstone	cornerstone	NOUN
gs-4060	81	11	of	of	ADP
gs-4060	81	12	modern	modern	ADJ
gs-4060	81	13	oncology	oncology	NOUN
gs-4060	81	14	,	,	PUNCT
gs-4060	81	15	yet	yet	CCONJ
gs-4060	81	16	it	it	PRON
gs-4060	81	17	also	also	ADV
gs-4060	81	18	introduces	introduce	VERB
gs-4060	81	19	a	a	DET
gs-4060	81	20	new	new	ADJ
gs-4060	81	21	layer	layer	NOUN
gs-4060	81	22	of	of	ADP
gs-4060	81	23	complexity	complexity	NOUN
gs-4060	81	24	for	for	ADP
gs-4060	81	25	clinicians	clinician	NOUN
gs-4060	81	26	,	,	PUNCT
gs-4060	81	27	researchers	researcher	NOUN
gs-4060	81	28	,	,	PUNCT
gs-4060	81	29	and	and	CCONJ
gs-4060	81	30	pharmacologists	pharmacologist	NOUN
gs-4060	81	31	.	.	PUNCT
gs-4060	82	1	the	the	DET
gs-4060	82	2	traditional	traditional	ADJ
gs-4060	82	3	classification	classification	NOUN
gs-4060	82	4	systems	system	NOUN
gs-4060	82	5	based	base	VERB
gs-4060	82	6	merely	merely	ADV
gs-4060	82	7	on	on	ADP
gs-4060	82	8	chemical	chemical	ADJ
gs-4060	82	9	structure	structure	NOUN
gs-4060	82	10	or	or	CCONJ
gs-4060	82	11	cell	cell	NOUN
gs-4060	82	12	cycle	cycle	NOUN
gs-4060	82	13	specificity	specificity	NOUN
gs-4060	82	14	are	be	AUX
gs-4060	82	15	no	no	ADV
gs-4060	82	16	longer	long	ADV
gs-4060	82	17	sufficient	sufficient	ADJ
gs-4060	82	18	to	to	PART
gs-4060	82	19	encompass	encompass	VERB
gs-4060	82	20	the	the	DET
gs-4060	82	21	diversity	diversity	NOUN
gs-4060	82	22	and	and	CCONJ
gs-4060	82	23	sophistication	sophistication	NOUN
gs-4060	82	24	of	of	ADP
gs-4060	82	25	these	these	DET
gs-4060	82	26	new	new	ADJ
gs-4060	82	27	modalities	modality	NOUN
gs-4060	82	28	.	.	PUNCT
gs-4060	83	1	we	we	PRON
gs-4060	83	2	are	be	AUX
gs-4060	83	3	now	now	ADV
gs-4060	83	4	required	require	VERB
gs-4060	83	5	to	to	PART
gs-4060	83	6	adopt	adopt	VERB
gs-4060	83	7	a	a	DET
gs-4060	83	8	multifaceted	multifaceted	ADJ
gs-4060	83	9	framework	framework	NOUN
gs-4060	83	10	that	that	PRON
gs-4060	83	11	categorizes	categorize	VERB
gs-4060	83	12	agents	agent	NOUN
gs-4060	83	13	based	base	VERB
gs-4060	83	14	on	on	ADP
gs-4060	83	15	their	their	PRON
gs-4060	83	16	biological	biological	ADJ
gs-4060	83	17	targets	target	NOUN
gs-4060	83	18	and	and	CCONJ
gs-4060	83	19	fundamental	fundamental	ADJ
gs-4060	83	20	mechanisms	mechanism	NOUN
gs-4060	83	21	of	of	ADP
gs-4060	83	22	action	action	NOUN
gs-4060	83	23	.	.	PUNCT
gs-4060	84	1	this	this	DET
gs-4060	84	2	new	new	ADJ
gs-4060	84	3	taxonomy	taxonomy	NOUN
gs-4060	84	4	includes	include	VERB
gs-4060	84	5	broad	broad	ADJ
gs-4060	84	6	categories	category	NOUN
gs-4060	84	7	such	such	ADJ
gs-4060	84	8	as	as	ADP
gs-4060	84	9	molecularly	molecularly	ADV
gs-4060	84	10	targeted	target	VERB
gs-4060	84	11	agents	agent	NOUN
gs-4060	84	12	and	and	CCONJ
gs-4060	84	13	immunotherapeutic	immunotherapeutic	ADJ
gs-4060	84	14	agents	agent	NOUN
gs-4060	84	15	,	,	PUNCT
gs-4060	84	16	each	each	PRON
gs-4060	84	17	with	with	ADP
gs-4060	84	18	numerous	numerous	ADJ
gs-4060	84	19	subclasses	subclass	NOUN
gs-4060	84	20	.	.	PUNCT
gs-4060	85	1	targeted	target	VERB
gs-4060	85	2	therapies	therapy	NOUN
gs-4060	85	3	themselves	themselves	PRON
gs-4060	85	4	can	can	AUX
gs-4060	85	5	be	be	AUX
gs-4060	85	6	divided	divide	VERB
gs-4060	85	7	into	into	ADP
gs-4060	85	8	small	small	ADJ
gs-4060	85	9	molecule	molecule	NOUN
gs-4060	85	10	inhibitors	inhibitor	NOUN
gs-4060	85	11	,	,	PUNCT
gs-4060	85	12	designed	design	VERB
gs-4060	85	13	to	to	PART
gs-4060	85	14	penetrate	penetrate	VERB
gs-4060	85	15	cells	cell	NOUN
gs-4060	85	16	and	and	CCONJ
gs-4060	85	17	block	block	VERB
gs-4060	85	18	specific	specific	ADJ
gs-4060	85	19	intracellular	intracellular	ADJ
gs-4060	85	20	enzymes	enzyme	NOUN
gs-4060	85	21	like	like	ADP
gs-4060	85	22	tyrosine	tyrosine	NOUN
gs-4060	85	23	kinases	kinase	NOUN
gs-4060	85	24	,	,	PUNCT
gs-4060	85	25	and	and	CCONJ
gs-4060	85	26	monoclonal	monoclonal	NOUN
gs-4060	85	27	antibodies	antibody	NOUN
gs-4060	85	28	,	,	PUNCT
gs-4060	85	29	which	which	PRON
gs-4060	85	30	typically	typically	ADV
gs-4060	85	31	target	target	VERB
gs-4060	85	32	extracellular	extracellular	ADJ
gs-4060	85	33	ligands	ligand	NOUN
gs-4060	85	34	or	or	CCONJ
gs-4060	85	35	cell	cell	NOUN
gs-4060	85	36	surface	surface	NOUN
gs-4060	85	37	receptors	receptor	NOUN
gs-4060	85	38	with	with	ADP
gs-4060	85	39	high	high	ADJ
gs-4060	85	40	specificity	specificity	NOUN
gs-4060	85	41	.	.	PUNCT
gs-4060	86	1	immunooncology	immunooncology	NOUN
gs-4060	86	2	,	,	PUNCT
gs-4060	86	3	a	a	DET
gs-4060	86	4	field	field	NOUN
gs-4060	86	5	that	that	PRON
gs-4060	86	6	has	have	AUX
gs-4060	86	7	revolutionized	revolutionize	VERB
gs-4060	86	8	the	the	DET
gs-4060	86	9	treatment	treatment	NOUN
gs-4060	86	10	of	of	ADP
gs-4060	86	11	certain	certain	ADJ
gs-4060	86	12	advanced	advanced	ADJ
gs-4060	86	13	cancers	cancer	NOUN
gs-4060	86	14	,	,	PUNCT
gs-4060	86	15	encompasses	encompass	VERB
gs-4060	86	16	immune	immune	ADJ
gs-4060	86	17	checkpoint	checkpoint	NOUN
gs-4060	86	18	inhibitors	inhibitor	NOUN
gs-4060	86	19	,	,	PUNCT
gs-4060	86	20	which	which	PRON
gs-4060	86	21	release	release	VERB
gs-4060	86	22	the	the	DET
gs-4060	86	23	brakes	brake	NOUN
gs-4060	86	24	on	on	ADP
gs-4060	86	25	the	the	DET
gs-4060	86	26	immune	immune	ADJ
gs-4060	86	27	system	system	NOUN
gs-4060	86	28	,	,	PUNCT
gs-4060	86	29	chimeric	chimeric	ADJ
gs-4060	86	30	antigen	antigen	ADJ
gs-4060	86	31	receptor	receptor	NOUN
gs-4060	86	32	(	(	PUNCT
gs-4060	86	33	car	car	NOUN
gs-4060	86	34	)	)	PUNCT
gs-4060	86	35	t	t	NOUN
gs-4060	86	36	-	-	PUNCT
gs-4060	86	37	cell	cell	NOUN
gs-4060	86	38	therapies	therapy	NOUN
gs-4060	86	39	,	,	PUNCT
gs-4060	86	40	which	which	PRON
gs-4060	86	41	are	be	AUX
gs-4060	86	42	genetically	genetically	ADV
gs-4060	86	43	engineered	engineer	VERB
gs-4060	86	44	to	to	PART
gs-4060	86	45	direct	direct	VERB
gs-4060	86	46	a	a	DET
gs-4060	86	47	patient	patient	NOUN
gs-4060	86	48	’s	’s	PART
gs-4060	86	49	own	own	ADJ
gs-4060	86	50	immune	immune	ADJ
gs-4060	86	51	cells	cell	NOUN
gs-4060	86	52	against	against	ADP
gs-4060	86	53	the	the	DET
gs-4060	86	54	tumor	tumor	NOUN
gs-4060	86	55	,	,	PUNCT
gs-4060	86	56	and	and	CCONJ
gs-4060	86	57	therapeutic	therapeutic	ADJ
gs-4060	86	58	cancer	cancer	NOUN
gs-4060	86	59	vaccines	vaccine	NOUN
gs-4060	86	60	.	.	PUNCT
gs-4060	87	1	understanding	understand	VERB
gs-4060	87	2	the	the	DET
gs-4060	87	3	pharmacological	pharmacological	ADJ
gs-4060	87	4	principles	principle	NOUN
gs-4060	87	5	of	of	ADP
gs-4060	87	6	these	these	DET
gs-4060	87	7	agents	agent	NOUN
gs-4060	87	8	is	be	AUX
gs-4060	87	9	paramount	paramount	ADJ
gs-4060	87	10	.	.	PUNCT
gs-4060	88	1	their	their	PRON
gs-4060	88	2	features	feature	NOUN
gs-4060	88	3	—	—	PUNCT
gs-4060	88	4	from	from	ADP
gs-4060	88	5	their	their	PRON
gs-4060	88	6	design	design	NOUN
gs-4060	88	7	and	and	CCONJ
gs-4060	88	8	chemical	chemical	NOUN
gs-4060	88	9	properties	property	NOUN
gs-4060	88	10	to	to	ADP
gs-4060	88	11	their	their	PRON
gs-4060	88	12	absorption	absorption	NOUN
gs-4060	88	13	,	,	PUNCT
gs-4060	88	14	distribution	distribution	NOUN
gs-4060	88	15	,	,	PUNCT
gs-4060	88	16	metabolism	metabolism	NOUN
gs-4060	88	17	,	,	PUNCT
gs-4060	88	18	and	and	CCONJ
gs-4060	88	19	excretion	excretion	NOUN
gs-4060	88	20	(	(	PUNCT
gs-4060	88	21	pharmacokinetics)—are	pharmacokinetics)—are	AUX
gs-4060	88	22	intrinsically	intrinsically	ADV
gs-4060	88	23	linked	link	VERB
gs-4060	88	24	to	to	ADP
gs-4060	88	25	their	their	PRON
gs-4060	88	26	mechanism	mechanism	NOUN
gs-4060	88	27	of	of	ADP
gs-4060	88	28	action	action	NOUN
gs-4060	88	29	and	and	CCONJ
gs-4060	88	30	clinical	clinical	ADJ
gs-4060	88	31	utility	utility	NOUN
gs-4060	88	32	.	.	PUNCT
gs-4060	89	1	the	the	DET
gs-4060	89	2	pharmacodynamics	pharmacodynamic	NOUN
gs-4060	89	3	,	,	PUNCT
gs-4060	89	4	which	which	PRON
gs-4060	89	5	describe	describe	VERB
gs-4060	89	6	the	the	DET
gs-4060	89	7	biochemical	biochemical	ADJ
gs-4060	89	8	and	and	CCONJ
gs-4060	89	9	physiological	physiological	ADJ
gs-4060	89	10	effects	effect	NOUN
gs-4060	89	11	of	of	ADP
gs-4060	89	12	the	the	DET
gs-4060	89	13	drug	drug	NOUN
gs-4060	89	14	,	,	PUNCT
gs-4060	89	15	including	include	VERB
gs-4060	89	16	the	the	DET
gs-4060	89	17	relationship	relationship	NOUN
gs-4060	89	18	between	between	ADP
gs-4060	89	19	its	its	PRON
gs-4060	89	20	concentration	concentration	NOUN
gs-4060	89	21	and	and	CCONJ
gs-4060	89	22	the	the	DET
gs-4060	89	23	resulting	result	VERB
gs-4060	89	24	therapeutic	therapeutic	ADJ
gs-4060	89	25	or	or	CCONJ
gs-4060	89	26	toxic	toxic	ADJ
gs-4060	89	27	effects	effect	NOUN
gs-4060	89	28	,	,	PUNCT
gs-4060	89	29	are	be	AUX
gs-4060	89	30	often	often	ADV
gs-4060	89	31	more	more	ADV
gs-4060	89	32	complex	complex	ADJ
gs-4060	89	33	and	and	CCONJ
gs-4060	89	34	unpredictable	unpredictable	ADJ
gs-4060	89	35	than	than	ADP
gs-4060	89	36	those	those	PRON
gs-4060	89	37	of	of	ADP
gs-4060	89	38	cytotoxic	cytotoxic	ADJ
gs-4060	89	39	drugs	drug	NOUN
gs-4060	89	40	.	.	PUNCT
gs-4060	90	1	for	for	ADP
gs-4060	90	2	instance	instance	NOUN
gs-4060	90	3	,	,	PUNCT
gs-4060	90	4	the	the	DET
gs-4060	90	5	efficacy	efficacy	NOUN
gs-4060	90	6	of	of	ADP
gs-4060	90	7	a	a	DET
gs-4060	90	8	tyrosine	tyrosine	NOUN
gs-4060	90	9	kinase	kinase	PROPN
gs-4060	90	10	inhibitor	inhibitor	NOUN
gs-4060	90	11	is	be	AUX
gs-4060	90	12	not	not	PART
gs-4060	90	13	only	only	ADV
gs-4060	90	14	dependent	dependent	ADJ
gs-4060	90	15	on	on	ADP
gs-4060	90	16	achieving	achieve	VERB
gs-4060	90	17	a	a	DET
gs-4060	90	18	sufficient	sufficient	ADJ
gs-4060	90	19	plasma	plasma	NOUN
gs-4060	90	20	concentration	concentration	NOUN
gs-4060	90	21	but	but	CCONJ
gs-4060	90	22	also	also	ADV
gs-4060	90	23	on	on	ADP
gs-4060	90	24	the	the	DET
gs-4060	90	25	presence	presence	NOUN
gs-4060	90	26	and	and	CCONJ
gs-4060	90	27	dominance	dominance	NOUN
gs-4060	90	28	of	of	ADP
gs-4060	90	29	the	the	DET
gs-4060	90	30	specific	specific	ADJ
gs-4060	90	31	genetic	genetic	ADJ
gs-4060	90	32	mutation	mutation	NOUN
gs-4060	90	33	it	it	PRON
gs-4060	90	34	targets	target	VERB
gs-4060	90	35	within	within	ADP
gs-4060	90	36	the	the	DET
gs-4060	90	37	tumor	tumor	NOUN
gs-4060	90	38	.	.	PUNCT
gs-4060	91	1	this	this	PRON
gs-4060	91	2	introduces	introduce	VERB
gs-4060	91	3	the	the	DET
gs-4060	91	4	critical	critical	ADJ
gs-4060	91	5	concept	concept	NOUN
gs-4060	91	6	of	of	ADP
gs-4060	91	7	companion	companion	NOUN
gs-4060	91	8	diagnostics	diagnostic	NOUN
gs-4060	91	9	,	,	PUNCT
gs-4060	91	10	where	where	SCONJ
gs-4060	91	11	biomarker	biomarker	NOUN
gs-4060	91	12	testing	testing	NOUN
gs-4060	91	13	is	be	AUX
gs-4060	91	14	an	an	DET
gs-4060	91	15	essential	essential	ADJ
gs-4060	91	16	prerequisite	prerequisite	NOUN
gs-4060	91	17	for	for	ADP
gs-4060	91	18	treatment	treatment	NOUN
gs-4060	91	19	selection	selection	NOUN
gs-4060	91	20	,	,	PUNCT
gs-4060	91	21	ensuring	ensure	VERB
gs-4060	91	22	that	that	SCONJ
gs-4060	91	23	the	the	DET
gs-4060	91	24	right	right	ADJ
gs-4060	91	25	drug	drug	NOUN
gs-4060	91	26	is	be	AUX
gs-4060	91	27	matched	match	VERB
gs-4060	91	28	to	to	ADP
gs-4060	91	29	the	the	DET
gs-4060	91	30	right	right	ADJ
gs-4060	91	31	patient	patient	NOUN
gs-4060	91	32	.	.	PUNCT
gs-4060	92	1	the	the	DET
gs-4060	92	2	clinical	clinical	ADJ
gs-4060	92	3	use	use	NOUN
gs-4060	92	4	of	of	ADP
gs-4060	92	5	these	these	DET
gs-4060	92	6	novel	novel	ADJ
gs-4060	92	7	agents	agent	NOUN
gs-4060	92	8	is	be	AUX
gs-4060	92	9	fundamentally	fundamentally	ADV
gs-4060	92	10	different	different	ADJ
gs-4060	92	11	from	from	ADP
gs-4060	92	12	traditional	traditional	ADJ
gs-4060	92	13	chemotherapy	chemotherapy	NOUN
gs-4060	92	14	.	.	PUNCT
gs-4060	93	1	they	they	PRON
gs-4060	93	2	are	be	AUX
gs-4060	93	3	often	often	ADV
gs-4060	93	4	approved	approve	VERB
gs-4060	93	5	for	for	ADP
gs-4060	93	6	use	use	NOUN
gs-4060	93	7	in	in	ADP
gs-4060	93	8	specific	specific	ADJ
gs-4060	93	9	biomarker	biomarker	NOUN
gs-4060	93	10	-	-	PUNCT
gs-4060	93	11	selected	select	VERB
gs-4060	93	12	populations	population	NOUN
gs-4060	93	13	,	,	PUNCT
gs-4060	93	14	as	as	SCONJ
gs-4060	93	15	defined	define	VERB
gs-4060	93	16	in	in	ADP
gs-4060	93	17	their	their	PRON
gs-4060	93	18	label	label	NOUN
gs-4060	93	19	,	,	PUNCT
gs-4060	93	20	and	and	CCONJ
gs-4060	93	21	their	their	PRON
gs-4060	93	22	administration	administration	NOUN
gs-4060	93	23	can	can	AUX
gs-4060	93	24	be	be	AUX
gs-4060	93	25	continuous	continuous	ADJ
gs-4060	93	26	over	over	ADP
gs-4060	93	27	long	long	ADJ
gs-4060	93	28	periods	period	NOUN
gs-4060	93	29	,	,	PUNCT
gs-4060	93	30	transforming	transform	VERB
gs-4060	93	31	advanced	advanced	ADJ
gs-4060	93	32	cancer	cancer	NOUN
gs-4060	93	33	into	into	ADP
gs-4060	93	34	a	a	DET
gs-4060	93	35	chronic	chronic	NOUN
gs-4060	93	36	,	,	PUNCT
gs-4060	93	37	manageable	manageable	ADJ
gs-4060	93	38	condition	condition	NOUN
gs-4060	93	39	for	for	ADP
gs-4060	93	40	some	some	DET
gs-4060	93	41	patients	patient	NOUN
gs-4060	93	42	.	.	PUNCT
gs-4060	94	1	the	the	DET
gs-4060	94	2	treatment	treatment	NOUN
gs-4060	94	3	endpoints	endpoint	NOUN
gs-4060	94	4	have	have	AUX
gs-4060	94	5	also	also	ADV
gs-4060	94	6	evolved	evolve	VERB
gs-4060	94	7	,	,	PUNCT
gs-4060	94	8	with	with	ADP
gs-4060	94	9	unusual	unusual	ADJ
gs-4060	94	10	response	response	NOUN
gs-4060	94	11	patterns	pattern	NOUN
gs-4060	94	12	such	such	ADJ
gs-4060	94	13	as	as	ADP
gs-4060	94	14	pseudoprogression	pseudoprogression	NOUN
gs-4060	94	15	observed	observe	VERB
gs-4060	94	16	with	with	ADP
gs-4060	94	17	immunotherapies	immunotherapy	NOUN
gs-4060	94	18	,	,	PUNCT
gs-4060	94	19	necessitating	necessitate	VERB
gs-4060	94	20	new	new	ADJ
gs-4060	94	21	criteria	criterion	NOUN
gs-4060	94	22	for	for	ADP
gs-4060	94	23	evaluating	evaluate	VERB
gs-4060	94	24	radiographic	radiographic	ADJ
gs-4060	94	25	response	response	NOUN
gs-4060	94	26	.	.	PUNCT
gs-4060	95	1	furthermore	furthermore	ADV
gs-4060	95	2	,	,	PUNCT
gs-4060	95	3	the	the	DET
gs-4060	95	4	toxicity	toxicity	NOUN
gs-4060	95	5	profiles	profile	NOUN
gs-4060	95	6	of	of	ADP
gs-4060	95	7	these	these	DET
gs-4060	95	8	new	new	ADJ
gs-4060	95	9	drugs	drug	NOUN
gs-4060	95	10	are	be	AUX
gs-4060	95	11	distinct	distinct	ADJ
gs-4060	95	12	and	and	CCONJ
gs-4060	95	13	require	require	VERB
gs-4060	95	14	vigilant	vigilant	ADJ
gs-4060	95	15	management	management	NOUN
gs-4060	95	16	.	.	PUNCT
gs-4060	96	1	while	while	SCONJ
gs-4060	96	2	they	they	PRON
gs-4060	96	3	may	may	AUX
gs-4060	96	4	georgian	georgian	VERB
gs-4060	96	5	scientists/	scientists/	NUM
gs-4060	96	6	.	.	PUNCT
gs-4060	97	1	7	7	NUM
gs-4060	97	2	n	n	PRON
gs-4060	97	3	3	3	NUM
gs-4060	97	4	,	,	PUNCT
gs-4060	97	5	2025	2025	NUM
gs-4060	97	6	575	575	NUM
gs-4060	97	7	avoid	avoid	VERB
gs-4060	97	8	the	the	DET
gs-4060	97	9	classic	classic	ADJ
gs-4060	97	10	cytotoxic	cytotoxic	ADJ
gs-4060	97	11	side	side	NOUN
gs-4060	97	12	effects	effect	NOUN
gs-4060	97	13	,	,	PUNCT
gs-4060	97	14	they	they	PRON
gs-4060	97	15	are	be	AUX
gs-4060	97	16	associated	associate	VERB
gs-4060	97	17	with	with	ADP
gs-4060	97	18	a	a	DET
gs-4060	97	19	entirely	entirely	ADV
gs-4060	97	20	new	new	ADJ
gs-4060	97	21	spectrum	spectrum	NOUN
gs-4060	97	22	of	of	ADP
gs-4060	97	23	adverse	adverse	ADJ
gs-4060	97	24	events	event	NOUN
gs-4060	97	25	.	.	PUNCT
gs-4060	98	1	targeted	target	VERB
gs-4060	98	2	therapies	therapy	NOUN
gs-4060	98	3	can	can	AUX
gs-4060	98	4	cause	cause	VERB
gs-4060	98	5	specific	specific	ADJ
gs-4060	98	6	on	on	ADP
gs-4060	98	7	-	-	PUNCT
gs-4060	98	8	target	target	NOUN
gs-4060	98	9	toxicities	toxicity	NOUN
gs-4060	98	10	,	,	PUNCT
gs-4060	98	11	such	such	ADJ
gs-4060	98	12	as	as	ADP
gs-4060	98	13	skin	skin	NOUN
gs-4060	98	14	rash	rash	ADJ
gs-4060	98	15	with	with	ADP
gs-4060	98	16	egfr	egfr	ADJ
gs-4060	98	17	inhibitors	inhibitor	NOUN
gs-4060	98	18	or	or	CCONJ
gs-4060	98	19	hypertension	hypertension	NOUN
gs-4060	98	20	with	with	ADP
gs-4060	98	21	vegf	vegf	PROPN
gs-4060	98	22	inhibitors	inhibitor	NOUN
gs-4060	98	23	,	,	PUNCT
gs-4060	98	24	which	which	PRON
gs-4060	98	25	are	be	AUX
gs-4060	98	26	mechanism	mechanism	NOUN
gs-4060	98	27	-	-	PUNCT
gs-4060	98	28	based	base	VERB
gs-4060	98	29	and	and	CCONJ
gs-4060	98	30	often	often	ADV
gs-4060	98	31	manageable	manageable	ADJ
gs-4060	98	32	with	with	ADP
gs-4060	98	33	supportive	supportive	ADJ
gs-4060	98	34	care	care	NOUN
gs-4060	98	35	.	.	PUNCT
gs-4060	99	1	immunotherapies	immunotherapy	NOUN
gs-4060	99	2	can	can	AUX
gs-4060	99	3	lead	lead	VERB
gs-4060	99	4	to	to	ADP
gs-4060	99	5	immune	immune	NOUN
gs-4060	99	6	-	-	PUNCT
gs-4060	99	7	related	relate	VERB
gs-4060	99	8	adverse	adverse	ADJ
gs-4060	99	9	events	event	NOUN
gs-4060	99	10	(	(	PUNCT
gs-4060	99	11	iraes	iraes	NOUN
gs-4060	99	12	)	)	PUNCT
gs-4060	99	13	,	,	PUNCT
gs-4060	99	14	which	which	PRON
gs-4060	99	15	are	be	AUX
gs-4060	99	16	autoimmune	autoimmune	ADJ
gs-4060	99	17	-	-	PUNCT
gs-4060	99	18	like	like	ADJ
gs-4060	99	19	phenomena	phenomenon	NOUN
gs-4060	99	20	that	that	PRON
gs-4060	99	21	can	can	AUX
gs-4060	99	22	affect	affect	VERB
gs-4060	99	23	any	any	DET
gs-4060	99	24	organ	organ	NOUN
gs-4060	99	25	system	system	NOUN
gs-4060	99	26	,	,	PUNCT
gs-4060	99	27	including	include	VERB
gs-4060	99	28	the	the	DET
gs-4060	99	29	colon	colon	NOUN
gs-4060	99	30	(	(	PUNCT
gs-4060	99	31	colitis	colitis	NOUN
gs-4060	99	32	)	)	PUNCT
gs-4060	99	33	,	,	PUNCT
gs-4060	99	34	lungs	lung	NOUN
gs-4060	99	35	(	(	PUNCT
gs-4060	99	36	pneumonitis	pneumonitis	NOUN
gs-4060	99	37	)	)	PUNCT
gs-4060	99	38	,	,	PUNCT
gs-4060	99	39	liver	liver	NOUN
gs-4060	99	40	(	(	PUNCT
gs-4060	99	41	hepatitis	hepatitis	NOUN
gs-4060	99	42	)	)	PUNCT
gs-4060	99	43	,	,	PUNCT
gs-4060	99	44	and	and	CCONJ
gs-4060	99	45	endocrine	endocrine	NOUN
gs-4060	99	46	glands	gland	NOUN
gs-4060	99	47	(	(	PUNCT
gs-4060	99	48	thyroiditis	thyroiditis	NOUN
gs-4060	99	49	,	,	PUNCT
gs-4060	99	50	hypophysitis	hypophysitis	NOUN
gs-4060	99	51	)	)	PUNCT
gs-4060	99	52	.	.	PUNCT
gs-4060	100	1	these	these	DET
gs-4060	100	2	iraes	irae	NOUN
gs-4060	100	3	demand	demand	VERB
gs-4060	100	4	early	early	ADJ
gs-4060	100	5	recognition	recognition	NOUN
gs-4060	100	6	and	and	CCONJ
gs-4060	100	7	intervention	intervention	NOUN
gs-4060	100	8	with	with	ADP
gs-4060	100	9	immunosuppressive	immunosuppressive	ADJ
gs-4060	100	10	agents	agent	NOUN
gs-4060	100	11	like	like	ADP
gs-4060	100	12	corticosteroids	corticosteroid	NOUN
gs-4060	100	13	to	to	PART
gs-4060	100	14	prevent	prevent	VERB
gs-4060	100	15	life	life	NOUN
gs-4060	100	16	-	-	PUNCT
gs-4060	100	17	threatening	threaten	VERB
gs-4060	100	18	complications	complication	NOUN
gs-4060	100	19	.	.	PUNCT
gs-4060	101	1	therefore	therefore	ADV
gs-4060	101	2	,	,	PUNCT
gs-4060	101	3	a	a	DET
gs-4060	101	4	comprehensive	comprehensive	ADJ
gs-4060	101	5	exploration	exploration	NOUN
gs-4060	101	6	of	of	ADP
gs-4060	101	7	the	the	DET
gs-4060	101	8	scientific	scientific	ADJ
gs-4060	101	9	aspects	aspect	NOUN
gs-4060	101	10	of	of	ADP
gs-4060	101	11	these	these	DET
gs-4060	101	12	new	new	ADJ
gs-4060	101	13	anticancer	anticancer	NOUN
gs-4060	101	14	drugs	drug	NOUN
gs-4060	101	15	is	be	AUX
gs-4060	101	16	not	not	PART
gs-4060	101	17	merely	merely	ADV
gs-4060	101	18	an	an	DET
gs-4060	101	19	academic	academic	ADJ
gs-4060	101	20	exercise	exercise	NOUN
gs-4060	101	21	but	but	CCONJ
gs-4060	101	22	a	a	DET
gs-4060	101	23	clinical	clinical	ADJ
gs-4060	101	24	imperative	imperative	NOUN
gs-4060	101	25	.	.	PUNCT
gs-4060	102	1	this	this	DET
gs-4060	102	2	review	review	NOUN
gs-4060	102	3	aims	aim	VERB
gs-4060	102	4	to	to	PART
gs-4060	102	5	provide	provide	VERB
gs-4060	102	6	a	a	DET
gs-4060	102	7	detailed	detailed	ADJ
gs-4060	102	8	synthesis	synthesis	NOUN
gs-4060	102	9	of	of	ADP
gs-4060	102	10	the	the	DET
gs-4060	102	11	current	current	ADJ
gs-4060	102	12	landscape	landscape	NOUN
gs-4060	102	13	,	,	PUNCT
gs-4060	102	14	delving	delve	VERB
gs-4060	102	15	into	into	ADP
gs-4060	102	16	the	the	DET
gs-4060	102	17	modern	modern	ADJ
gs-4060	102	18	classification	classification	NOUN
gs-4060	102	19	schemes	scheme	NOUN
gs-4060	102	20	that	that	PRON
gs-4060	102	21	bring	bring	VERB
gs-4060	102	22	order	order	NOUN
gs-4060	102	23	to	to	ADP
gs-4060	102	24	this	this	DET
gs-4060	102	25	diverse	diverse	ADJ
gs-4060	102	26	therapeutic	therapeutic	ADJ
gs-4060	102	27	arena	arena	NOUN
gs-4060	102	28	.	.	PUNCT
gs-4060	103	1	it	it	PRON
gs-4060	103	2	will	will	AUX
gs-4060	103	3	elaborate	elaborate	VERB
gs-4060	103	4	on	on	ADP
gs-4060	103	5	the	the	DET
gs-4060	103	6	intricate	intricate	ADJ
gs-4060	103	7	mechanisms	mechanism	NOUN
gs-4060	103	8	by	by	ADP
gs-4060	103	9	which	which	PRON
gs-4060	103	10	these	these	DET
gs-4060	103	11	drugs	drug	NOUN
gs-4060	103	12	exert	exert	VERB
gs-4060	103	13	their	their	PRON
gs-4060	103	14	antitumor	antitumor	PROPN
gs-4060	103	15	effects	effect	NOUN
gs-4060	103	16	,	,	PUNCT
gs-4060	103	17	from	from	ADP
gs-4060	103	18	inhibiting	inhibit	VERB
gs-4060	103	19	proliferative	proliferative	ADJ
gs-4060	103	20	signals	signal	NOUN
gs-4060	103	21	and	and	CCONJ
gs-4060	103	22	inducing	induce	VERB
gs-4060	103	23	apoptosis	apoptosis	NOUN
gs-4060	103	24	to	to	ADP
gs-4060	103	25	unleashing	unleash	VERB
gs-4060	103	26	a	a	DET
gs-4060	103	27	potent	potent	ADJ
gs-4060	103	28	immune	immune	ADJ
gs-4060	103	29	response	response	NOUN
gs-4060	103	30	.	.	PUNCT
gs-4060	104	1	the	the	DET
gs-4060	104	2	discussion	discussion	NOUN
gs-4060	104	3	will	will	AUX
gs-4060	104	4	extend	extend	VERB
gs-4060	104	5	to	to	ADP
gs-4060	104	6	the	the	DET
gs-4060	104	7	fundamental	fundamental	ADJ
gs-4060	104	8	pharmacological	pharmacological	ADJ
gs-4060	104	9	properties	property	NOUN
gs-4060	104	10	that	that	PRON
gs-4060	104	11	govern	govern	VERB
gs-4060	104	12	their	their	PRON
gs-4060	104	13	behavior	behavior	NOUN
gs-4060	104	14	within	within	ADP
gs-4060	104	15	the	the	DET
gs-4060	104	16	body	body	NOUN
gs-4060	104	17	,	,	PUNCT
gs-4060	104	18	their	their	PRON
gs-4060	104	19	established	establish	VERB
gs-4060	104	20	and	and	CCONJ
gs-4060	104	21	emerging	emerge	VERB
gs-4060	104	22	clinical	clinical	ADJ
gs-4060	104	23	applications	application	NOUN
gs-4060	104	24	across	across	ADP
gs-4060	104	25	a	a	DET
gs-4060	104	26	spectrum	spectrum	NOUN
gs-4060	104	27	of	of	ADP
gs-4060	104	28	malignancies	malignancy	NOUN
gs-4060	104	29	,	,	PUNCT
gs-4060	104	30	and	and	CCONJ
gs-4060	104	31	the	the	DET
gs-4060	104	32	nuanced	nuanced	ADJ
gs-4060	104	33	management	management	NOUN
gs-4060	104	34	of	of	ADP
gs-4060	104	35	their	their	PRON
gs-4060	104	36	unique	unique	ADJ
gs-4060	104	37	and	and	CCONJ
gs-4060	104	38	often	often	ADV
gs-4060	104	39	unpredictable	unpredictable	ADJ
gs-4060	104	40	toxicities	toxicity	NOUN
gs-4060	104	41	.	.	PUNCT
gs-4060	105	1	by	by	ADP
gs-4060	105	2	integrating	integrate	VERB
gs-4060	105	3	insights	insight	NOUN
gs-4060	105	4	from	from	ADP
gs-4060	105	5	molecular	molecular	ADJ
gs-4060	105	6	biology	biology	NOUN
gs-4060	105	7	,	,	PUNCT
gs-4060	105	8	pharmacology	pharmacology	NOUN
gs-4060	105	9	,	,	PUNCT
gs-4060	105	10	and	and	CCONJ
gs-4060	105	11	clinical	clinical	ADJ
gs-4060	105	12	medicine	medicine	NOUN
gs-4060	105	13	,	,	PUNCT
gs-4060	105	14	this	this	DET
gs-4060	105	15	analysis	analysis	NOUN
gs-4060	105	16	seeks	seek	VERB
gs-4060	105	17	to	to	PART
gs-4060	105	18	illuminate	illuminate	VERB
gs-4060	105	19	the	the	DET
gs-4060	105	20	remarkable	remarkable	ADJ
gs-4060	105	21	progress	progress	NOUN
gs-4060	105	22	achieved	achieve	VERB
gs-4060	105	23	in	in	ADP
gs-4060	105	24	the	the	DET
gs-4060	105	25	fight	fight	NOUN
gs-4060	105	26	against	against	ADP
gs-4060	105	27	cancer	cancer	NOUN
gs-4060	105	28	while	while	SCONJ
gs-4060	105	29	also	also	ADV
gs-4060	105	30	acknowledging	acknowledge	VERB
gs-4060	105	31	the	the	DET
gs-4060	105	32	ongoing	ongoing	ADJ
gs-4060	105	33	challenges	challenge	NOUN
gs-4060	105	34	—	—	PUNCT
gs-4060	105	35	such	such	ADJ
gs-4060	105	36	as	as	ADP
gs-4060	105	37	primary	primary	ADJ
gs-4060	105	38	and	and	CCONJ
gs-4060	105	39	acquired	acquire	VERB
gs-4060	105	40	resistance	resistance	NOUN
gs-4060	105	41	,	,	PUNCT
gs-4060	105	42	the	the	DET
gs-4060	105	43	high	high	ADJ
gs-4060	105	44	cost	cost	NOUN
gs-4060	105	45	of	of	ADP
gs-4060	105	46	development	development	NOUN
gs-4060	105	47	,	,	PUNCT
gs-4060	105	48	and	and	CCONJ
gs-4060	105	49	access	access	NOUN
gs-4060	105	50	to	to	ADP
gs-4060	105	51	treatment	treatment	NOUN
gs-4060	105	52	—	—	PUNCT
gs-4060	105	53	that	that	PRON
gs-4060	105	54	must	must	AUX
gs-4060	105	55	be	be	AUX
gs-4060	105	56	addressed	address	VERB
gs-4060	105	57	to	to	PART
gs-4060	105	58	fully	fully	ADV
gs-4060	105	59	realize	realize	VERB
gs-4060	105	60	the	the	DET
gs-4060	105	61	potential	potential	NOUN
gs-4060	105	62	of	of	ADP
gs-4060	105	63	this	this	DET
gs-4060	105	64	new	new	ADJ
gs-4060	105	65	era	era	NOUN
gs-4060	105	66	in	in	ADP
gs-4060	105	67	oncology	oncology	NOUN
gs-4060	105	68	.	.	PUNCT
gs-4060	106	1	the	the	DET
gs-4060	106	2	journey	journey	NOUN
gs-4060	106	3	from	from	ADP
gs-4060	106	4	a	a	DET
gs-4060	106	5	nonspecific	nonspecific	ADJ
gs-4060	106	6	cytotoxic	cytotoxic	ADJ
gs-4060	106	7	attack	attack	NOUN
gs-4060	106	8	to	to	ADP
gs-4060	106	9	a	a	DET
gs-4060	106	10	precise	precise	ADJ
gs-4060	106	11	,	,	PUNCT
gs-4060	106	12	biomarker	biomarker	NOUN
gs-4060	106	13	-	-	PUNCT
gs-4060	106	14	guided	guide	VERB
gs-4060	106	15	strategic	strategic	ADJ
gs-4060	106	16	intervention	intervention	NOUN
gs-4060	106	17	marks	mark	VERB
gs-4060	106	18	one	one	NUM
gs-4060	106	19	of	of	ADP
gs-4060	106	20	the	the	DET
gs-4060	106	21	most	most	ADV
gs-4060	106	22	significant	significant	ADJ
gs-4060	106	23	advancements	advancement	NOUN
gs-4060	106	24	in	in	ADP
gs-4060	106	25	modern	modern	ADJ
gs-4060	106	26	medicine	medicine	NOUN
gs-4060	106	27	,	,	PUNCT
gs-4060	106	28	offering	offer	VERB
gs-4060	106	29	renewed	renew	VERB
gs-4060	106	30	hope	hope	NOUN
gs-4060	106	31	and	and	CCONJ
gs-4060	106	32	extended	extended	ADJ
gs-4060	106	33	survival	survival	NOUN
gs-4060	106	34	for	for	ADP
gs-4060	106	35	countless	countless	ADJ
gs-4060	106	36	patients	patient	NOUN
gs-4060	106	37	worldwide	worldwide	ADV
gs-4060	106	38	.	.	PUNCT
gs-4060	107	1	emerging	emerge	VERB
gs-4060	107	2	drug	drug	NOUN
gs-4060	107	3	classes	class	NOUN
gs-4060	107	4	,	,	PUNCT
gs-4060	107	5	such	such	ADJ
gs-4060	107	6	as	as	ADP
gs-4060	107	7	adcs	adcs	ADJ
gs-4060	107	8	(	(	PUNCT
gs-4060	107	9	e.g.	e.g.	ADV
gs-4060	107	10	,	,	PUNCT
gs-4060	107	11	trastuzumab	trastuzumab	NOUN
gs-4060	107	12	deruxtecan	deruxtecan	ADJ
gs-4060	107	13	)	)	PUNCT
gs-4060	107	14	,	,	PUNCT
gs-4060	107	15	combine	combine	VERB
gs-4060	107	16	the	the	DET
gs-4060	107	17	specificity	specificity	NOUN
gs-4060	107	18	of	of	ADP
gs-4060	107	19	monoclonal	monoclonal	NOUN
gs-4060	107	20	antibodies	antibody	NOUN
gs-4060	107	21	with	with	ADP
gs-4060	107	22	potent	potent	ADJ
gs-4060	107	23	cytotoxic	cytotoxic	ADJ
gs-4060	107	24	payloads	payload	NOUN
gs-4060	107	25	,	,	PUNCT
gs-4060	107	26	offering	offer	VERB
gs-4060	107	27	improved	improve	VERB
gs-4060	107	28	tumor	tumor	NOUN
gs-4060	107	29	targeting	target	VERB
gs-4060	107	30	.	.	PUNCT
gs-4060	108	1	immune	immune	ADJ
gs-4060	108	2	checkpoint	checkpoint	NOUN
gs-4060	108	3	inhibitors	inhibitor	NOUN
gs-4060	108	4	,	,	PUNCT
gs-4060	108	5	including	include	VERB
gs-4060	108	6	anti	anti	ADJ
gs-4060	108	7	-	-	ADJ
gs-4060	108	8	pd-1	pd-1	ADJ
gs-4060	108	9	/	/	SYM
gs-4060	108	10	pd	pd	ADJ
gs-4060	108	11	-	-	PUNCT
gs-4060	108	12	l1	l1	PROPN
gs-4060	108	13	agents	agent	NOUN
gs-4060	108	14	like	like	ADP
gs-4060	108	15	pembrolizumab	pembrolizumab	NOUN
gs-4060	108	16	and	and	CCONJ
gs-4060	108	17	nivolumab	nivolumab	NOUN
gs-4060	108	18	,	,	PUNCT
gs-4060	108	19	have	have	AUX
gs-4060	108	20	transformed	transform	VERB
gs-4060	108	21	treatment	treatment	NOUN
gs-4060	108	22	for	for	ADP
gs-4060	108	23	cancers	cancer	NOUN
gs-4060	108	24	like	like	ADP
gs-4060	108	25	melanoma	melanoma	NOUN
gs-4060	108	26	and	and	CCONJ
gs-4060	108	27	non	non	ADJ
gs-4060	108	28	-	-	ADJ
gs-4060	108	29	small	small	ADJ
gs-4060	108	30	cell	cell	NOUN
gs-4060	108	31	lung	lung	NOUN
gs-4060	108	32	cancer	cancer	NOUN
gs-4060	108	33	(	(	PUNCT
gs-4060	108	34	nsclc	nsclc	NOUN
gs-4060	108	35	)	)	PUNCT
gs-4060	108	36	by	by	ADP
gs-4060	108	37	unleashing	unleash	VERB
gs-4060	108	38	t	t	PROPN
gs-4060	108	39	-	-	PUNCT
gs-4060	108	40	cell	cell	NOUN
gs-4060	108	41	responses	response	NOUN
gs-4060	108	42	.	.	PUNCT
gs-4060	109	1	tkis	tkis	NOUN
gs-4060	109	2	,	,	PUNCT
gs-4060	109	3	such	such	ADJ
gs-4060	109	4	as	as	ADP
gs-4060	109	5	osimertinib	osimertinib	NOUN
gs-4060	109	6	for	for	ADP
gs-4060	109	7	egfr	egfr	ADV
gs-4060	109	8	-	-	PUNCT
gs-4060	109	9	mutated	mutate	VERB
gs-4060	109	10	nsclc	nsclc	NOUN
gs-4060	109	11	,	,	PUNCT
gs-4060	109	12	target	target	VERB
gs-4060	109	13	specific	specific	ADJ
gs-4060	109	14	oncogenic	oncogenic	ADJ
gs-4060	109	15	pathways	pathway	NOUN
gs-4060	109	16	,	,	PUNCT
gs-4060	109	17	while	while	SCONJ
gs-4060	109	18	natural	natural	ADJ
gs-4060	109	19	products	product	NOUN
gs-4060	109	20	(	(	PUNCT
gs-4060	109	21	e.g.	e.g.	ADV
gs-4060	109	22	,	,	PUNCT
gs-4060	109	23	paclitaxel	paclitaxel	NOUN
gs-4060	109	24	,	,	PUNCT
gs-4060	109	25	curcumin	curcumin	NOUN
gs-4060	109	26	)	)	PUNCT
gs-4060	109	27	and	and	CCONJ
gs-4060	109	28	repurposed	repurpose	VERB
gs-4060	109	29	drugs	drug	NOUN
gs-4060	109	30	(	(	PUNCT
gs-4060	109	31	e.g.	e.g.	ADV
gs-4060	109	32	,	,	PUNCT
gs-4060	109	33	metformin	metformin	NOUN
gs-4060	109	34	,	,	PUNCT
gs-4060	109	35	statins	statin	NOUN
gs-4060	109	36	)	)	PUNCT
gs-4060	109	37	offer	offer	VERB
gs-4060	109	38	cost	cost	NOUN
gs-4060	109	39	-	-	PUNCT
gs-4060	109	40	effective	effective	ADJ
gs-4060	109	41	alternatives	alternative	NOUN
gs-4060	109	42	with	with	ADP
gs-4060	109	43	novel	novel	ADJ
gs-4060	109	44	mechanisms	mechanism	NOUN
gs-4060	109	45	.	.	PUNCT
gs-4060	110	1	advances	advance	NOUN
gs-4060	110	2	in	in	ADP
gs-4060	110	3	drug	drug	NOUN
gs-4060	110	4	delivery	delivery	NOUN
gs-4060	110	5	,	,	PUNCT
gs-4060	110	6	including	include	VERB
gs-4060	110	7	nanoparticles	nanoparticle	NOUN
gs-4060	110	8	,	,	PUNCT
gs-4060	110	9	liposomes	liposome	NOUN
gs-4060	110	10	,	,	PUNCT
gs-4060	110	11	and	and	CCONJ
gs-4060	110	12	microneedles	microneedle	NOUN
gs-4060	110	13	,	,	PUNCT
gs-4060	110	14	address	address	VERB
gs-4060	110	15	challenges	challenge	NOUN
gs-4060	110	16	like	like	ADP
gs-4060	110	17	poor	poor	ADJ
gs-4060	110	18	bioavailability	bioavailability	NOUN
gs-4060	110	19	and	and	CCONJ
gs-4060	110	20	systemic	systemic	ADJ
gs-4060	110	21	toxicity	toxicity	NOUN
gs-4060	110	22	,	,	PUNCT
gs-4060	110	23	enhancing	enhance	VERB
gs-4060	110	24	therapeutic	therapeutic	ADJ
gs-4060	110	25	precision	precision	NOUN
gs-4060	110	26	.	.	PUNCT
gs-4060	111	1	despite	despite	SCONJ
gs-4060	111	2	these	these	DET
gs-4060	111	3	advancements	advancement	NOUN
gs-4060	111	4	,	,	PUNCT
gs-4060	111	5	significant	significant	ADJ
gs-4060	111	6	challenges	challenge	NOUN
gs-4060	111	7	persist	persist	VERB
gs-4060	111	8	.	.	PUNCT
gs-4060	112	1	drug	drug	NOUN
gs-4060	112	2	resistance	resistance	NOUN
gs-4060	112	3	,	,	PUNCT
gs-4060	112	4	driven	drive	VERB
gs-4060	112	5	by	by	ADP
gs-4060	112	6	mechanisms	mechanism	NOUN
gs-4060	112	7	such	such	ADJ
gs-4060	112	8	as	as	ADP
gs-4060	112	9	target	target	NOUN
gs-4060	112	10	mutations	mutation	NOUN
gs-4060	112	11	(	(	PUNCT
gs-4060	112	12	e.g.	e.g.	ADV
gs-4060	112	13	,	,	PUNCT
gs-4060	112	14	egfr	egfr	VERB
gs-4060	112	15	t790	t790	NUM
gs-4060	112	16	m	m	NOUN
gs-4060	112	17	)	)	PUNCT
gs-4060	112	18	,	,	PUNCT
gs-4060	112	19	pathway	pathway	NOUN
gs-4060	112	20	bypassing	bypassing	NOUN
gs-4060	112	21	,	,	PUNCT
gs-4060	112	22	and	and	CCONJ
gs-4060	112	23	tumor	tumor	NOUN
gs-4060	112	24	microenvironment	microenvironment	ADJ
gs-4060	112	25	interactions	interaction	NOUN
gs-4060	112	26	,	,	PUNCT
gs-4060	112	27	limits	limit	VERB
gs-4060	112	28	long	long	ADJ
gs-4060	112	29	-	-	PUNCT
gs-4060	112	30	term	term	NOUN
gs-4060	112	31	efficacy	efficacy	NOUN
gs-4060	112	32	.	.	PUNCT
gs-4060	113	1	toxicities	toxicity	NOUN
gs-4060	113	2	,	,	PUNCT
gs-4060	113	3	ranging	range	VERB
gs-4060	113	4	from	from	ADP
gs-4060	113	5	myelosuppression	myelosuppression	NOUN
gs-4060	113	6	and	and	CCONJ
gs-4060	113	7	cardiotoxicity	cardiotoxicity	NOUN
gs-4060	113	8	to	to	ADP
gs-4060	113	9	immune	immune	NOUN
gs-4060	113	10	-	-	PUNCT
gs-4060	113	11	related	relate	VERB
gs-4060	113	12	adverse	adverse	ADJ
gs-4060	113	13	events	event	NOUN
gs-4060	113	14	,	,	PUNCT
gs-4060	113	15	necessitate	necessitate	ADJ
gs-4060	113	16	careful	careful	ADJ
gs-4060	113	17	management	management	NOUN
gs-4060	113	18	through	through	ADP
gs-4060	113	19	dose	dose	NOUN
gs-4060	113	20	optimization	optimization	NOUN
gs-4060	113	21	,	,	PUNCT
gs-4060	113	22	supportive	supportive	ADJ
gs-4060	113	23	care	care	NOUN
gs-4060	113	24	,	,	PUNCT
gs-4060	113	25	and	and	CCONJ
gs-4060	113	26	pharmacogenomic	pharmacogenomic	ADJ
gs-4060	113	27	profiling	profiling	NOUN
gs-4060	113	28	.	.	PUNCT
gs-4060	114	1	the	the	DET
gs-4060	114	2	high	high	ADJ
gs-4060	114	3	failure	failure	NOUN
gs-4060	114	4	rate	rate	NOUN
gs-4060	114	5	of	of	ADP
gs-4060	114	6	drug	drug	NOUN
gs-4060	114	7	candidates	candidate	NOUN
gs-4060	114	8	—	—	PUNCT
gs-4060	114	9	over	over	ADP
gs-4060	114	10	90	90	NUM
gs-4060	114	11	.	.	PUNCT
gs-4060	115	1	the	the	DET
gs-4060	115	2	global	global	ADJ
gs-4060	115	3	burden	burden	NOUN
gs-4060	115	4	of	of	ADP
gs-4060	115	5	cancer	cancer	NOUN
gs-4060	115	6	also	also	ADV
gs-4060	115	7	raises	raise	VERB
gs-4060	115	8	ethical	ethical	ADJ
gs-4060	115	9	and	and	CCONJ
gs-4060	115	10	accessibility	accessibility	NOUN
gs-4060	115	11	concerns	concern	NOUN
gs-4060	115	12	.	.	PUNCT
gs-4060	116	1	high	high	ADJ
gs-4060	116	2	costs	cost	NOUN
gs-4060	116	3	of	of	ADP
gs-4060	116	4	novel	novel	ADJ
gs-4060	116	5	therapies	therapy	NOUN
gs-4060	116	6	,	,	PUNCT
gs-4060	116	7	particularly	particularly	ADV
gs-4060	116	8	biologics	biologic	NOUN
gs-4060	116	9	and	and	CCONJ
gs-4060	116	10	car	car	NOUN
gs-4060	116	11	-	-	PUNCT
gs-4060	116	12	t	t	NOUN
gs-4060	116	13	,	,	PUNCT
gs-4060	116	14	limit	limit	VERB
gs-4060	116	15	access	access	NOUN
gs-4060	116	16	in	in	ADP
gs-4060	116	17	lowand	lowand	ADJ
gs-4060	116	18	middle	middle	ADJ
gs-4060	116	19	-	-	PUNCT
gs-4060	116	20	income	income	NOUN
gs-4060	116	21	countries	country	NOUN
gs-4060	116	22	,	,	PUNCT
gs-4060	116	23	exacerbating	exacerbate	VERB
gs-4060	116	24	health	health	NOUN
gs-4060	116	25	disparities	disparity	NOUN
gs-4060	116	26	.	.	PUNCT
gs-4060	117	1	efforts	effort	NOUN
gs-4060	117	2	to	to	PART
gs-4060	117	3	repurpose	repurpose	VERB
gs-4060	117	4	existing	exist	VERB
gs-4060	117	5	drugs	drug	NOUN
gs-4060	117	6	,	,	PUNCT
gs-4060	117	7	such	such	ADJ
gs-4060	117	8	as	as	ADP
gs-4060	117	9	metformin	metformin	NOUN
gs-4060	117	10	for	for	ADP
gs-4060	117	11	its	its	PRON
gs-4060	117	12	antimetabolic	antimetabolic	ADJ
gs-4060	117	13	effects	effect	NOUN
gs-4060	117	14	or	or	CCONJ
gs-4060	117	15	disulfiram	disulfiram	NOUN
gs-4060	117	16	for	for	ADP
gs-4060	117	17	glycolysis	glycolysis	NOUN
gs-4060	117	18	inhibition	inhibition	NOUN
gs-4060	117	19	,	,	PUNCT
gs-4060	117	20	aim	aim	VERB
gs-4060	117	21	to	to	PART
gs-4060	117	22	provide	provide	VERB
gs-4060	117	23	affordable	affordable	ADJ
gs-4060	117	24	options	option	NOUN
gs-4060	117	25	.	.	PUNCT
gs-4060	118	1	georgian	georgian	NOUN
gs-4060	118	2	scientists/	scientists/	NUM
gs-4060	118	3	.	.	PUNCT
gs-4060	119	1	7	7	NUM
gs-4060	119	2	n	n	PRON
gs-4060	119	3	3	3	NUM
gs-4060	119	4	,	,	PUNCT
gs-4060	119	5	2025	2025	NUM
gs-4060	119	6	576	576	NUM
gs-4060	119	7	additionally	additionally	ADV
gs-4060	119	8	,	,	PUNCT
gs-4060	119	9	natural	natural	ADJ
gs-4060	119	10	products	product	NOUN
gs-4060	119	11	like	like	ADP
gs-4060	119	12	artemisinin	artemisinin	NOUN
gs-4060	119	13	derivatives	derivative	NOUN
gs-4060	119	14	and	and	CCONJ
gs-4060	119	15	betulinic	betulinic	ADJ
gs-4060	119	16	acid	acid	PROPN
gs-4060	119	17	are	be	AUX
gs-4060	119	18	being	be	AUX
gs-4060	119	19	explored	explore	VERB
gs-4060	119	20	for	for	ADP
gs-4060	119	21	their	their	PRON
gs-4060	119	22	multitargeted	multitargete	VERB
gs-4060	119	23	effects	effect	NOUN
gs-4060	119	24	,	,	PUNCT
gs-4060	119	25	offering	offer	VERB
gs-4060	119	26	potential	potential	NOUN
gs-4060	119	27	in	in	ADP
gs-4060	119	28	resource	resource	NOUN
gs-4060	119	29	-	-	PUNCT
gs-4060	119	30	limited	limit	VERB
gs-4060	119	31	settings	setting	NOUN
gs-4060	119	32	.	.	PUNCT
gs-4060	120	1	this	this	DET
gs-4060	120	2	article	article	NOUN
gs-4060	120	3	synthesizes	synthesize	VERB
gs-4060	120	4	current	current	ADJ
gs-4060	120	5	knowledge	knowledge	NOUN
gs-4060	120	6	on	on	ADP
gs-4060	120	7	new	new	ADJ
gs-4060	120	8	anticancer	anticancer	NOUN
gs-4060	120	9	drugs	drug	NOUN
gs-4060	120	10	,	,	PUNCT
gs-4060	120	11	drawing	draw	VERB
gs-4060	120	12	from	from	ADP
gs-4060	120	13	clinical	clinical	ADJ
gs-4060	120	14	trials	trial	NOUN
gs-4060	120	15	,	,	PUNCT
gs-4060	120	16	pharmacological	pharmacological	ADJ
gs-4060	120	17	studies	study	NOUN
gs-4060	120	18	,	,	PUNCT
gs-4060	120	19	and	and	CCONJ
gs-4060	120	20	emerging	emerge	VERB
gs-4060	120	21	trends	trend	NOUN
gs-4060	120	22	up	up	ADV
gs-4060	120	23	to	to	ADP
gs-4060	120	24	2025	2025	NUM
gs-4060	120	25	.	.	PUNCT
gs-4060	121	1	it	it	PRON
gs-4060	121	2	explores	explore	VERB
gs-4060	121	3	how	how	SCONJ
gs-4060	121	4	these	these	DET
gs-4060	121	5	agents	agent	NOUN
gs-4060	121	6	are	be	AUX
gs-4060	121	7	reshaping	reshape	VERB
gs-4060	121	8	oncology	oncology	NOUN
gs-4060	121	9	through	through	ADP
gs-4060	121	10	precision	precision	NOUN
gs-4060	121	11	medicine	medicine	NOUN
gs-4060	121	12	,	,	PUNCT
gs-4060	121	13	while	while	SCONJ
gs-4060	121	14	addressing	address	VERB
gs-4060	121	15	the	the	DET
gs-4060	121	16	scientific	scientific	ADJ
gs-4060	121	17	,	,	PUNCT
gs-4060	121	18	clinical	clinical	ADJ
gs-4060	121	19	,	,	PUNCT
gs-4060	121	20	and	and	CCONJ
gs-4060	121	21	societal	societal	ADJ
gs-4060	121	22	challenges	challenge	NOUN
gs-4060	121	23	that	that	PRON
gs-4060	121	24	remain	remain	VERB
gs-4060	121	25	.	.	PUNCT
gs-4060	122	1	by	by	ADP
gs-4060	122	2	examining	examine	VERB
gs-4060	122	3	the	the	DET
gs-4060	122	4	interplay	interplay	NOUN
gs-4060	122	5	of	of	ADP
gs-4060	122	6	molecular	molecular	ADJ
gs-4060	122	7	mechanisms	mechanism	NOUN
gs-4060	122	8	,	,	PUNCT
gs-4060	122	9	pharmacological	pharmacological	ADJ
gs-4060	122	10	properties	property	NOUN
gs-4060	122	11	,	,	PUNCT
gs-4060	122	12	and	and	CCONJ
gs-4060	122	13	clinical	clinical	ADJ
gs-4060	122	14	outcomes	outcome	NOUN
gs-4060	122	15	,	,	PUNCT
gs-4060	122	16	this	this	DET
gs-4060	122	17	review	review	NOUN
gs-4060	122	18	aims	aim	VERB
gs-4060	122	19	to	to	PART
gs-4060	122	20	provide	provide	VERB
gs-4060	122	21	a	a	DET
gs-4060	122	22	comprehensive	comprehensive	ADJ
gs-4060	122	23	resource	resource	NOUN
gs-4060	122	24	for	for	ADP
gs-4060	122	25	researchers	researcher	NOUN
gs-4060	122	26	,	,	PUNCT
gs-4060	122	27	clinicians	clinician	NOUN
gs-4060	122	28	,	,	PUNCT
gs-4060	122	29	and	and	CCONJ
gs-4060	122	30	policymakers	policymaker	NOUN
gs-4060	122	31	navigating	navigate	VERB
gs-4060	122	32	the	the	DET
gs-4060	122	33	evolving	evolve	VERB
gs-4060	122	34	landscape	landscape	NOUN
gs-4060	122	35	of	of	ADP
gs-4060	122	36	cancer	cancer	NOUN
gs-4060	122	37	therapeutics	therapeutic	NOUN
gs-4060	122	38	.	.	PUNCT
gs-4060	123	1	the	the	DET
gs-4060	123	2	following	follow	VERB
gs-4060	123	3	sections	section	NOUN
gs-4060	123	4	delve	delve	VERB
gs-4060	123	5	into	into	ADP
gs-4060	123	6	the	the	DET
gs-4060	123	7	detailed	detailed	ADJ
gs-4060	123	8	classification	classification	NOUN
gs-4060	123	9	of	of	ADP
gs-4060	123	10	anticancer	anticancer	NOUN
gs-4060	123	11	drugs	drug	NOUN
gs-4060	123	12	,	,	PUNCT
gs-4060	123	13	their	their	PRON
gs-4060	123	14	historical	historical	ADJ
gs-4060	123	15	context	context	NOUN
gs-4060	123	16	,	,	PUNCT
gs-4060	123	17	and	and	CCONJ
gs-4060	123	18	the	the	DET
gs-4060	123	19	scientific	scientific	ADJ
gs-4060	123	20	principles	principle	NOUN
gs-4060	123	21	underpinning	underpin	VERB
gs-4060	123	22	their	their	PRON
gs-4060	123	23	development	development	NOUN
gs-4060	123	24	.	.	PUNCT
gs-4060	124	1	subsequent	subsequent	ADJ
gs-4060	124	2	discussions	discussion	NOUN
gs-4060	124	3	cover	cover	VERB
gs-4060	124	4	specific	specific	ADJ
gs-4060	124	5	mechanisms	mechanism	NOUN
gs-4060	124	6	of	of	ADP
gs-4060	124	7	action	action	NOUN
gs-4060	124	8	,	,	PUNCT
gs-4060	124	9	pharmacological	pharmacological	ADJ
gs-4060	124	10	profiles	profile	NOUN
gs-4060	124	11	,	,	PUNCT
gs-4060	124	12	clinical	clinical	ADJ
gs-4060	124	13	applications	application	NOUN
gs-4060	124	14	,	,	PUNCT
gs-4060	124	15	therapeutic	therapeutic	ADJ
gs-4060	124	16	effects	effect	NOUN
gs-4060	124	17	,	,	PUNCT
gs-4060	124	18	and	and	CCONJ
gs-4060	124	19	toxicity	toxicity	NOUN
gs-4060	124	20	profiles	profile	NOUN
gs-4060	124	21	,	,	PUNCT
gs-4060	124	22	with	with	ADP
gs-4060	124	23	a	a	DET
gs-4060	124	24	focus	focus	NOUN
gs-4060	124	25	on	on	ADP
gs-4060	124	26	recent	recent	ADJ
gs-4060	124	27	innovations	innovation	NOUN
gs-4060	124	28	and	and	CCONJ
gs-4060	124	29	future	future	ADJ
gs-4060	124	30	directions	direction	NOUN
gs-4060	124	31	.	.	PUNCT
gs-4060	125	1	this	this	DET
gs-4060	125	2	holistic	holistic	ADJ
gs-4060	125	3	approach	approach	NOUN
gs-4060	125	4	underscores	underscore	VERB
gs-4060	125	5	the	the	DET
gs-4060	125	6	transformative	transformative	ADJ
gs-4060	125	7	potential	potential	NOUN
gs-4060	125	8	of	of	ADP
gs-4060	125	9	new	new	ADJ
gs-4060	125	10	anticancer	anticancer	NOUN
gs-4060	125	11	drugs	drug	NOUN
gs-4060	125	12	while	while	SCONJ
gs-4060	125	13	acknowledging	acknowledge	VERB
gs-4060	125	14	the	the	DET
gs-4060	125	15	complexities	complexity	NOUN
gs-4060	125	16	of	of	ADP
gs-4060	125	17	translating	translate	VERB
gs-4060	125	18	scientific	scientific	ADJ
gs-4060	125	19	advancements	advancement	NOUN
gs-4060	125	20	into	into	ADP
gs-4060	125	21	equitable	equitable	ADJ
gs-4060	125	22	,	,	PUNCT
gs-4060	125	23	effective	effective	ADJ
gs-4060	125	24	clinical	clinical	ADJ
gs-4060	125	25	practice	practice	NOUN
gs-4060	125	26	.	.	PUNCT
gs-4060	126	1	evolution	evolution	NOUN
gs-4060	126	2	of	of	ADP
gs-4060	126	3	anticancer	anticancer	NOUN
gs-4060	126	4	drug	drug	NOUN
gs-4060	126	5	development	development	NOUN
gs-4060	126	6	the	the	DET
gs-4060	126	7	evolution	evolution	NOUN
gs-4060	126	8	of	of	ADP
gs-4060	126	9	anticancer	anticancer	NOUN
gs-4060	126	10	drugs	drug	NOUN
gs-4060	126	11	reflects	reflect	VERB
gs-4060	126	12	a	a	DET
gs-4060	126	13	convergence	convergence	NOUN
gs-4060	126	14	of	of	ADP
gs-4060	126	15	serendipity	serendipity	NOUN
gs-4060	126	16	,	,	PUNCT
gs-4060	126	17	scientific	scientific	ADJ
gs-4060	126	18	rigor	rigor	NOUN
gs-4060	126	19	,	,	PUNCT
gs-4060	126	20	and	and	CCONJ
gs-4060	126	21	technological	technological	ADJ
gs-4060	126	22	innovation	innovation	NOUN
gs-4060	126	23	.	.	PUNCT
gs-4060	127	1	early	early	ADJ
gs-4060	127	2	chemotherapeutics	chemotherapeutic	NOUN
gs-4060	127	3	were	be	AUX
gs-4060	127	4	derived	derive	VERB
gs-4060	127	5	from	from	ADP
gs-4060	127	6	chemical	chemical	ADJ
gs-4060	127	7	warfare	warfare	NOUN
gs-4060	127	8	agents	agent	NOUN
gs-4060	127	9	,	,	PUNCT
gs-4060	127	10	with	with	ADP
gs-4060	127	11	nitrogen	nitrogen	NOUN
gs-4060	127	12	mustards	mustard	NOUN
gs-4060	127	13	demonstrating	demonstrate	VERB
gs-4060	127	14	cytotoxic	cytotoxic	ADJ
gs-4060	127	15	effects	effect	NOUN
gs-4060	127	16	during	during	ADP
gs-4060	127	17	world	world	PROPN
gs-4060	127	18	war	war	PROPN
gs-4060	127	19	ii	ii	PROPN
gs-4060	127	20	.	.	PUNCT
gs-4060	128	1	these	these	DET
gs-4060	128	2	findings	finding	NOUN
gs-4060	128	3	led	lead	VERB
gs-4060	128	4	to	to	ADP
gs-4060	128	5	the	the	DET
gs-4060	128	6	development	development	NOUN
gs-4060	128	7	of	of	ADP
gs-4060	128	8	alkylating	alkylate	VERB
gs-4060	128	9	agents	agent	NOUN
gs-4060	128	10	,	,	PUNCT
gs-4060	128	11	which	which	PRON
gs-4060	128	12	covalently	covalently	ADV
gs-4060	128	13	bind	bind	VERB
gs-4060	128	14	dna	dna	NOUN
gs-4060	128	15	to	to	PART
gs-4060	128	16	prevent	prevent	VERB
gs-4060	128	17	replication	replication	NOUN
gs-4060	128	18	.	.	PUNCT
gs-4060	129	1	the	the	DET
gs-4060	129	2	discovery	discovery	NOUN
gs-4060	129	3	of	of	ADP
gs-4060	129	4	methotrexate	methotrexate	NOUN
gs-4060	129	5	,	,	PUNCT
gs-4060	129	6	an	an	DET
gs-4060	129	7	antifolate	antifolate	NOUN
gs-4060	129	8	,	,	PUNCT
gs-4060	129	9	emerged	emerge	VERB
gs-4060	129	10	from	from	ADP
gs-4060	129	11	observations	observation	NOUN
gs-4060	129	12	of	of	ADP
gs-4060	129	13	folate	folate	NOUN
gs-4060	129	14	deficiency	deficiency	NOUN
gs-4060	129	15	in	in	ADP
gs-4060	129	16	leukemia	leukemia	NOUN
gs-4060	129	17	patients	patient	NOUN
gs-4060	129	18	,	,	PUNCT
gs-4060	129	19	highlighting	highlight	VERB
gs-4060	129	20	the	the	DET
gs-4060	129	21	role	role	NOUN
gs-4060	129	22	of	of	ADP
gs-4060	129	23	metabolic	metabolic	NOUN
gs-4060	129	24	pathways	pathway	NOUN
gs-4060	129	25	in	in	ADP
gs-4060	129	26	cancer	cancer	NOUN
gs-4060	129	27	therapy	therapy	NOUN
gs-4060	129	28	.	.	PUNCT
gs-4060	130	1	the	the	DET
gs-4060	130	2	1960s	1960	NOUN
gs-4060	130	3	and	and	CCONJ
gs-4060	130	4	1970s	1970	NOUN
gs-4060	130	5	saw	see	VERB
gs-4060	130	6	the	the	DET
gs-4060	130	7	introduction	introduction	NOUN
gs-4060	130	8	of	of	ADP
gs-4060	130	9	plant	plant	NOUN
gs-4060	130	10	-	-	PUNCT
gs-4060	130	11	derived	derive	VERB
gs-4060	130	12	agents	agent	NOUN
gs-4060	130	13	,	,	PUNCT
gs-4060	130	14	such	such	ADJ
gs-4060	130	15	as	as	ADP
gs-4060	130	16	vinca	vinca	NOUN
gs-4060	130	17	alkaloids	alkaloid	NOUN
gs-4060	130	18	and	and	CCONJ
gs-4060	130	19	taxanes	taxane	NOUN
gs-4060	130	20	,	,	PUNCT
gs-4060	130	21	which	which	PRON
gs-4060	130	22	targeted	target	VERB
gs-4060	130	23	microtubules	microtubule	NOUN
gs-4060	130	24	to	to	PART
gs-4060	130	25	disrupt	disrupt	VERB
gs-4060	130	26	mitosis	mitosis	NOUN
gs-4060	130	27	.	.	PUNCT
gs-4060	131	1	these	these	DET
gs-4060	131	2	agents	agent	NOUN
gs-4060	131	3	,	,	PUNCT
gs-4060	131	4	while	while	SCONJ
gs-4060	131	5	effective	effective	ADJ
gs-4060	131	6	,	,	PUNCT
gs-4060	131	7	lacked	lack	VERB
gs-4060	131	8	specificity	specificity	NOUN
gs-4060	131	9	,	,	PUNCT
gs-4060	131	10	causing	cause	VERB
gs-4060	131	11	significant	significant	ADJ
gs-4060	131	12	off	off	ADP
gs-4060	131	13	-	-	PUNCT
gs-4060	131	14	target	target	NOUN
gs-4060	131	15	toxicities	toxicity	NOUN
gs-4060	131	16	.	.	PUNCT
gs-4060	132	1	the	the	DET
gs-4060	132	2	molecular	molecular	ADJ
gs-4060	132	3	biology	biology	NOUN
gs-4060	132	4	revolution	revolution	NOUN
gs-4060	132	5	of	of	ADP
gs-4060	132	6	the	the	DET
gs-4060	132	7	late	late	ADJ
gs-4060	132	8	20th	20th	ADJ
gs-4060	132	9	century	century	NOUN
gs-4060	132	10	shifted	shift	VERB
gs-4060	132	11	focus	focus	NOUN
gs-4060	132	12	to	to	ADP
gs-4060	132	13	targeted	target	VERB
gs-4060	132	14	therapies	therapy	NOUN
gs-4060	132	15	.	.	PUNCT
gs-4060	133	1	the	the	DET
gs-4060	133	2	identification	identification	NOUN
gs-4060	133	3	of	of	ADP
gs-4060	133	4	oncogenes	oncogene	NOUN
gs-4060	133	5	like	like	ADP
gs-4060	133	6	bcr	bcr	PROPN
gs-4060	133	7	-	-	PROPN
gs-4060	133	8	abl	abl	PROPN
gs-4060	133	9	in	in	ADP
gs-4060	133	10	cml	cml	PROPN
gs-4060	133	11	paved	pave	VERB
gs-4060	133	12	the	the	DET
gs-4060	133	13	way	way	NOUN
gs-4060	133	14	for	for	ADP
gs-4060	133	15	imatinib	imatinib	NOUN
gs-4060	133	16	,	,	PUNCT
gs-4060	133	17	a	a	DET
gs-4060	133	18	tki	tki	NOUN
gs-4060	133	19	that	that	PRON
gs-4060	133	20	selectively	selectively	ADV
gs-4060	133	21	inhibits	inhibit	VERB
gs-4060	133	22	aberrant	aberrant	ADJ
gs-4060	133	23	kinase	kinase	NOUN
gs-4060	133	24	activity	activity	NOUN
gs-4060	133	25	.	.	PUNCT
gs-4060	134	1	similarly	similarly	ADV
gs-4060	134	2	,	,	PUNCT
gs-4060	134	3	the	the	DET
gs-4060	134	4	discovery	discovery	NOUN
gs-4060	134	5	of	of	ADP
gs-4060	134	6	her2	her2	PROPN
gs-4060	134	7	amplification	amplification	NOUN
gs-4060	134	8	in	in	ADP
gs-4060	134	9	breast	breast	NOUN
gs-4060	134	10	cancer	cancer	NOUN
gs-4060	134	11	led	lead	VERB
gs-4060	134	12	to	to	ADP
gs-4060	134	13	trastuzumab	trastuzumab	NOUN
gs-4060	134	14	,	,	PUNCT
gs-4060	134	15	a	a	DET
gs-4060	134	16	monoclonal	monoclonal	NOUN
gs-4060	134	17	antibody	antibody	NOUN
gs-4060	134	18	that	that	PRON
gs-4060	134	19	improved	improve	VERB
gs-4060	134	20	survival	survival	NOUN
gs-4060	134	21	rates	rate	NOUN
gs-4060	134	22	.	.	PUNCT
gs-4060	135	1	these	these	DET
gs-4060	135	2	milestones	milestone	NOUN
gs-4060	135	3	marked	mark	VERB
gs-4060	135	4	the	the	DET
gs-4060	135	5	dawn	dawn	NOUN
gs-4060	135	6	of	of	ADP
gs-4060	135	7	precision	precision	NOUN
gs-4060	135	8	oncology	oncology	NOUN
gs-4060	135	9	,	,	PUNCT
gs-4060	135	10	where	where	SCONJ
gs-4060	135	11	therapies	therapy	NOUN
gs-4060	135	12	are	be	AUX
gs-4060	135	13	tailored	tailor	VERB
gs-4060	135	14	to	to	ADP
gs-4060	135	15	specific	specific	ADJ
gs-4060	135	16	genetic	genetic	ADJ
gs-4060	135	17	or	or	CCONJ
gs-4060	135	18	molecular	molecular	ADJ
gs-4060	135	19	profiles	profile	NOUN
gs-4060	135	20	.	.	PUNCT
gs-4060	136	1	in	in	ADP
gs-4060	136	2	recent	recent	ADJ
gs-4060	136	3	years	year	NOUN
gs-4060	136	4	,	,	PUNCT
gs-4060	136	5	the	the	DET
gs-4060	136	6	integration	integration	NOUN
gs-4060	136	7	of	of	ADP
gs-4060	136	8	genomics	genomic	NOUN
gs-4060	136	9	and	and	CCONJ
gs-4060	136	10	immunology	immunology	NOUN
gs-4060	136	11	has	have	AUX
gs-4060	136	12	accelerated	accelerate	VERB
gs-4060	136	13	progress	progress	NOUN
gs-4060	136	14	.	.	PUNCT
gs-4060	137	1	the	the	DET
gs-4060	137	2	completion	completion	NOUN
gs-4060	137	3	of	of	ADP
gs-4060	137	4	the	the	DET
gs-4060	137	5	human	human	ADJ
gs-4060	137	6	genome	genome	NOUN
gs-4060	137	7	project	project	NOUN
gs-4060	137	8	and	and	CCONJ
gs-4060	137	9	advancements	advancement	NOUN
gs-4060	137	10	in	in	ADP
gs-4060	137	11	next	next	ADJ
gs-4060	137	12	-	-	PUNCT
gs-4060	137	13	generation	generation	NOUN
gs-4060	137	14	sequencing	sequencing	NOUN
gs-4060	137	15	have	have	AUX
gs-4060	137	16	enabled	enable	VERB
gs-4060	137	17	the	the	DET
gs-4060	137	18	identification	identification	NOUN
gs-4060	137	19	of	of	ADP
gs-4060	137	20	driver	driver	NOUN
gs-4060	137	21	mutations	mutation	NOUN
gs-4060	137	22	,	,	PUNCT
gs-4060	137	23	facilitating	facilitate	VERB
gs-4060	137	24	the	the	DET
gs-4060	137	25	development	development	NOUN
gs-4060	137	26	of	of	ADP
gs-4060	137	27	drugs	drug	NOUN
gs-4060	137	28	like	like	ADP
gs-4060	137	29	osimertinib	osimertinib	NOUN
gs-4060	137	30	for	for	ADP
gs-4060	137	31	egfr	egfr	ADV
gs-4060	137	32	-	-	PUNCT
gs-4060	137	33	mutated	mutate	VERB
gs-4060	137	34	nsclc	nsclc	NOUN
gs-4060	137	35	.	.	PUNCT
gs-4060	138	1	immunotherapies	immunotherapy	NOUN
gs-4060	138	2	,	,	PUNCT
gs-4060	138	3	such	such	ADJ
gs-4060	138	4	as	as	ADP
gs-4060	138	5	pd-1	pd-1	ADP
gs-4060	138	6	/	/	SYM
gs-4060	138	7	pd	pd	ADJ
gs-4060	138	8	-	-	PUNCT
gs-4060	138	9	l1	l1	PROPN
gs-4060	138	10	inhibitors	inhibitor	NOUN
gs-4060	138	11	,	,	PUNCT
gs-4060	138	12	have	have	AUX
gs-4060	138	13	leveraged	leverage	VERB
gs-4060	138	14	the	the	DET
gs-4060	138	15	immune	immune	ADJ
gs-4060	138	16	system	system	NOUN
gs-4060	138	17	's	's	PART
gs-4060	138	18	potential	potential	NOUN
gs-4060	138	19	to	to	PART
gs-4060	138	20	recognize	recognize	VERB
gs-4060	138	21	and	and	CCONJ
gs-4060	138	22	destroy	destroy	VERB
gs-4060	138	23	cancer	cancer	NOUN
gs-4060	138	24	cells	cell	NOUN
gs-4060	138	25	,	,	PUNCT
gs-4060	138	26	achieving	achieve	VERB
gs-4060	138	27	durable	durable	ADJ
gs-4060	138	28	responses	response	NOUN
gs-4060	138	29	in	in	ADP
gs-4060	138	30	previously	previously	ADV
gs-4060	138	31	refractory	refractory	NOUN
gs-4060	138	32	diseases	disease	NOUN
gs-4060	138	33	.	.	PUNCT
gs-4060	139	1	current	current	ADJ
gs-4060	139	2	trends	trend	NOUN
gs-4060	139	3	in	in	ADP
gs-4060	139	4	anticancer	anticancer	NOUN
gs-4060	139	5	drug	drug	NOUN
gs-4060	139	6	development	development	NOUN
gs-4060	139	7	as	as	ADP
gs-4060	139	8	of	of	ADP
gs-4060	139	9	2025	2025	NUM
gs-4060	139	10	,	,	PUNCT
gs-4060	139	11	anticancer	anticancer	NOUN
gs-4060	139	12	drug	drug	NOUN
gs-4060	139	13	development	development	NOUN
gs-4060	139	14	is	be	AUX
gs-4060	139	15	characterized	characterize	VERB
gs-4060	139	16	by	by	ADP
gs-4060	139	17	several	several	ADJ
gs-4060	139	18	key	key	ADJ
gs-4060	139	19	trends	trend	NOUN
gs-4060	139	20	.	.	PUNCT
gs-4060	140	1	first	first	ADV
gs-4060	140	2	,	,	PUNCT
gs-4060	140	3	the	the	DET
gs-4060	140	4	rise	rise	NOUN
gs-4060	140	5	of	of	ADP
gs-4060	140	6	adcs	adcs	PROPN
gs-4060	140	7	has	have	AUX
gs-4060	140	8	revolutionized	revolutionize	VERB
gs-4060	140	9	targeted	target	VERB
gs-4060	140	10	therapy	therapy	NOUN
gs-4060	140	11	by	by	ADP
gs-4060	140	12	combining	combine	VERB
gs-4060	140	13	antibody	antibody	NOUN
gs-4060	140	14	specificity	specificity	NOUN
gs-4060	140	15	with	with	ADP
gs-4060	140	16	cytotoxic	cytotoxic	ADJ
gs-4060	140	17	payloads	payload	NOUN
gs-4060	140	18	.	.	PUNCT
gs-4060	141	1	drugs	drug	NOUN
gs-4060	141	2	like	like	ADP
gs-4060	141	3	sacituzumab	sacituzumab	NOUN
gs-4060	141	4	govitecan	govitecan	VERB
gs-4060	141	5	for	for	ADP
gs-4060	141	6	triple	triple	ADJ
gs-4060	141	7	-	-	PUNCT
gs-4060	141	8	negative	negative	ADJ
gs-4060	141	9	breast	breast	NOUN
gs-4060	141	10	cancer	cancer	NOUN
gs-4060	141	11	deliver	deliver	VERB
gs-4060	141	12	potent	potent	ADJ
gs-4060	141	13	agents	agent	NOUN
gs-4060	141	14	directly	directly	ADV
gs-4060	141	15	to	to	ADP
gs-4060	141	16	tumor	tumor	NOUN
gs-4060	141	17	cells	cell	NOUN
gs-4060	141	18	,	,	PUNCT
gs-4060	141	19	minimizing	minimize	VERB
gs-4060	141	20	systemic	systemic	ADJ
gs-4060	141	21	toxicity	toxicity	NOUN
gs-4060	141	22	.	.	PUNCT
gs-4060	142	1	second	second	ADJ
gs-4060	142	2	,	,	PUNCT
gs-4060	142	3	immunotherapies	immunotherapy	NOUN
gs-4060	142	4	,	,	PUNCT
gs-4060	142	5	particularly	particularly	ADV
gs-4060	142	6	georgian	georgian	NOUN
gs-4060	142	7	scientists/	scientists/	NUM
gs-4060	142	8	.	.	PUNCT
gs-4060	143	1	7	7	NUM
gs-4060	143	2	n	n	PRON
gs-4060	143	3	3	3	NUM
gs-4060	143	4	,	,	PUNCT
gs-4060	143	5	2025	2025	NUM
gs-4060	143	6	577	577	NUM
gs-4060	143	7	checkpoint	checkpoint	NOUN
gs-4060	143	8	inhibitors	inhibitor	NOUN
gs-4060	143	9	and	and	CCONJ
gs-4060	143	10	car	car	NOUN
gs-4060	143	11	-	-	PUNCT
gs-4060	143	12	t	t	NOUN
gs-4060	143	13	therapies	therapy	NOUN
gs-4060	143	14	,	,	PUNCT
gs-4060	143	15	have	have	AUX
gs-4060	143	16	expanded	expand	VERB
gs-4060	143	17	treatment	treatment	NOUN
gs-4060	143	18	options	option	NOUN
gs-4060	143	19	for	for	ADP
gs-4060	143	20	previously	previously	ADV
gs-4060	143	21	intractable	intractable	ADJ
gs-4060	143	22	cancers	cancer	NOUN
gs-4060	143	23	.	.	PUNCT
gs-4060	144	1	pembrolizumab	pembrolizumab	NOUN
gs-4060	144	2	,	,	PUNCT
gs-4060	144	3	for	for	ADP
gs-4060	144	4	instance	instance	NOUN
gs-4060	144	5	,	,	PUNCT
gs-4060	144	6	has	have	AUX
gs-4060	144	7	shown	show	VERB
gs-4060	144	8	durable	durable	ADJ
gs-4060	144	9	responses	response	NOUN
gs-4060	144	10	in	in	ADP
gs-4060	144	11	microsatellite	microsatellite	ADJ
gs-4060	144	12	instability	instability	NOUN
gs-4060	144	13	-	-	PUNCT
gs-4060	144	14	high	high	ADJ
gs-4060	144	15	(	(	PUNCT
gs-4060	144	16	msi	msi	PROPN
gs-4060	144	17	-	-	PROPN
gs-4060	144	18	h	h	NOUN
gs-4060	144	19	)	)	PUNCT
gs-4060	144	20	tumors	tumor	NOUN
gs-4060	144	21	across	across	ADP
gs-4060	144	22	multiple	multiple	ADJ
gs-4060	144	23	cancer	cancer	NOUN
gs-4060	144	24	types	type	NOUN
gs-4060	144	25	.	.	PUNCT
gs-4060	145	1	third	third	ADV
gs-4060	145	2	,	,	PUNCT
gs-4060	145	3	the	the	DET
gs-4060	145	4	exploration	exploration	NOUN
gs-4060	145	5	of	of	ADP
gs-4060	145	6	natural	natural	ADJ
gs-4060	145	7	products	product	NOUN
gs-4060	145	8	and	and	CCONJ
gs-4060	145	9	repurposed	repurpose	VERB
gs-4060	145	10	drugs	drug	NOUN
gs-4060	145	11	offers	offer	VERB
gs-4060	145	12	novel	novel	ADJ
gs-4060	145	13	therapeutic	therapeutic	ADJ
gs-4060	145	14	avenues	avenue	NOUN
gs-4060	145	15	.	.	PUNCT
gs-4060	146	1	compounds	compound	NOUN
gs-4060	146	2	like	like	ADP
gs-4060	146	3	curcumin	curcumin	NOUN
gs-4060	146	4	and	and	CCONJ
gs-4060	146	5	artemisinin	artemisinin	PROPN
gs-4060	146	6	derivatives	derivative	NOUN
gs-4060	146	7	target	target	VERB
gs-4060	146	8	multiple	multiple	ADJ
gs-4060	146	9	pathways	pathway	NOUN
gs-4060	146	10	,	,	PUNCT
gs-4060	146	11	including	include	VERB
gs-4060	146	12	pi3k	pi3k	PROPN
gs-4060	146	13	/	/	SYM
gs-4060	146	14	akt	akt	PROPN
gs-4060	146	15	/	/	SYM
gs-4060	146	16	mtor	mtor	PROPN
gs-4060	146	17	and	and	CCONJ
gs-4060	146	18	oxidative	oxidative	ADJ
gs-4060	146	19	stress	stress	NOUN
gs-4060	146	20	,	,	PUNCT
gs-4060	146	21	respectively	respectively	ADV
gs-4060	146	22	.	.	PUNCT
gs-4060	147	1	repurposed	repurpose	VERB
gs-4060	147	2	drugs	drug	NOUN
gs-4060	147	3	,	,	PUNCT
gs-4060	147	4	such	such	ADJ
gs-4060	147	5	as	as	ADP
gs-4060	147	6	metformin	metformin	NOUN
gs-4060	147	7	,	,	PUNCT
gs-4060	147	8	leverage	leverage	NOUN
gs-4060	147	9	metabolic	metabolic	NOUN
gs-4060	147	10	vulnerabilities	vulnerability	NOUN
gs-4060	147	11	in	in	ADP
gs-4060	147	12	cancer	cancer	NOUN
gs-4060	147	13	cells	cell	NOUN
gs-4060	147	14	,	,	PUNCT
gs-4060	147	15	providing	provide	VERB
gs-4060	147	16	cost	cost	NOUN
gs-4060	147	17	-	-	PUNCT
gs-4060	147	18	effective	effective	ADJ
gs-4060	147	19	alternatives	alternative	NOUN
gs-4060	147	20	.	.	PUNCT
gs-4060	148	1	finally	finally	ADV
gs-4060	148	2	,	,	PUNCT
gs-4060	148	3	advances	advance	NOUN
gs-4060	148	4	in	in	ADP
gs-4060	148	5	drug	drug	NOUN
gs-4060	148	6	delivery	delivery	NOUN
gs-4060	148	7	,	,	PUNCT
gs-4060	148	8	including	include	VERB
gs-4060	148	9	nanotechnology	nanotechnology	NOUN
gs-4060	148	10	and	and	CCONJ
gs-4060	148	11	hydrogels	hydrogel	NOUN
gs-4060	148	12	,	,	PUNCT
gs-4060	148	13	enhance	enhance	VERB
gs-4060	148	14	pharmacokinetic	pharmacokinetic	ADJ
gs-4060	148	15	profiles	profile	NOUN
gs-4060	148	16	and	and	CCONJ
gs-4060	148	17	reduce	reduce	VERB
gs-4060	148	18	adverse	adverse	ADJ
gs-4060	148	19	effects	effect	NOUN
gs-4060	148	20	.	.	PUNCT
gs-4060	149	1	these	these	DET
gs-4060	149	2	trends	trend	NOUN
gs-4060	149	3	reflect	reflect	VERB
gs-4060	149	4	a	a	DET
gs-4060	149	5	multidisciplinary	multidisciplinary	ADJ
gs-4060	149	6	approach	approach	NOUN
gs-4060	149	7	,	,	PUNCT
gs-4060	149	8	integrating	integrate	VERB
gs-4060	149	9	genomics	genomic	NOUN
gs-4060	149	10	,	,	PUNCT
gs-4060	149	11	immunology	immunology	NOUN
gs-4060	149	12	,	,	PUNCT
gs-4060	149	13	and	and	CCONJ
gs-4060	149	14	materials	material	NOUN
gs-4060	149	15	science	science	NOUN
gs-4060	149	16	to	to	PART
gs-4060	149	17	address	address	VERB
gs-4060	149	18	the	the	DET
gs-4060	149	19	multifaceted	multifaceted	ADJ
gs-4060	149	20	nature	nature	NOUN
gs-4060	149	21	of	of	ADP
gs-4060	149	22	cancer	cancer	NOUN
gs-4060	149	23	.	.	PUNCT
gs-4060	150	1	challenges	challenge	NOUN
gs-4060	150	2	and	and	CCONJ
gs-4060	150	3	opportunities	opportunity	NOUN
gs-4060	150	4	of	of	ADP
gs-4060	150	5	anticancer	anticancer	NOUN
gs-4060	150	6	drug	drug	NOUN
gs-4060	150	7	despite	despite	SCONJ
gs-4060	150	8	progress	progress	NOUN
gs-4060	150	9	,	,	PUNCT
gs-4060	150	10	several	several	ADJ
gs-4060	150	11	challenges	challenge	NOUN
gs-4060	150	12	hinder	hinder	VERB
gs-4060	150	13	the	the	DET
gs-4060	150	14	full	full	ADJ
gs-4060	150	15	potential	potential	NOUN
gs-4060	150	16	of	of	ADP
gs-4060	150	17	new	new	ADJ
gs-4060	150	18	anticancer	anticancer	NOUN
gs-4060	150	19	drugs	drug	NOUN
gs-4060	150	20	.	.	PUNCT
gs-4060	151	1	drug	drug	NOUN
gs-4060	151	2	resistance	resistance	NOUN
gs-4060	151	3	remains	remain	VERB
gs-4060	151	4	a	a	DET
gs-4060	151	5	critical	critical	ADJ
gs-4060	151	6	barrier	barrier	NOUN
gs-4060	151	7	,	,	PUNCT
gs-4060	151	8	with	with	ADP
gs-4060	151	9	mechanisms	mechanism	NOUN
gs-4060	151	10	including	include	VERB
gs-4060	151	11	efflux	efflux	NOUN
gs-4060	151	12	pumps	pump	NOUN
gs-4060	151	13	,	,	PUNCT
gs-4060	151	14	target	target	NOUN
gs-4060	151	15	mutations	mutation	NOUN
gs-4060	151	16	,	,	PUNCT
gs-4060	151	17	and	and	CCONJ
gs-4060	151	18	tumor	tumor	NOUN
gs-4060	151	19	microenvironment	microenvironment	ADJ
gs-4060	151	20	adaptations	adaptation	NOUN
gs-4060	151	21	.	.	PUNCT
gs-4060	152	1	for	for	ADP
gs-4060	152	2	example	example	NOUN
gs-4060	152	3	,	,	PUNCT
gs-4060	152	4	egfr	egfr	VERB
gs-4060	152	5	t790	t790	NUM
gs-4060	152	6	m	m	NOUN
gs-4060	152	7	mutations	mutation	NOUN
gs-4060	152	8	confer	confer	VERB
gs-4060	152	9	resistance	resistance	NOUN
gs-4060	152	10	to	to	ADP
gs-4060	152	11	first	first	ADJ
gs-4060	152	12	-	-	PUNCT
gs-4060	152	13	generation	generation	NOUN
gs-4060	152	14	tkis	tkis	NOUN
gs-4060	152	15	,	,	PUNCT
gs-4060	152	16	necessitating	necessitate	VERB
gs-4060	152	17	next	next	ADJ
gs-4060	152	18	-	-	PUNCT
gs-4060	152	19	generation	generation	NOUN
gs-4060	152	20	agents	agent	NOUN
gs-4060	152	21	like	like	ADP
gs-4060	152	22	osimertinib	osimertinib	NOUN
gs-4060	152	23	.	.	PUNCT
gs-4060	153	1	toxicity	toxicity	NOUN
gs-4060	153	2	profiles	profile	NOUN
gs-4060	153	3	,	,	PUNCT
gs-4060	153	4	such	such	ADJ
gs-4060	153	5	as	as	ADP
gs-4060	153	6	cardiotoxicity	cardiotoxicity	NOUN
gs-4060	153	7	from	from	ADP
gs-4060	153	8	anthracyclines	anthracycline	NOUN
gs-4060	153	9	or	or	CCONJ
gs-4060	153	10	immune	immune	NOUN
gs-4060	153	11	-	-	PUNCT
gs-4060	153	12	related	relate	VERB
gs-4060	153	13	colitis	colitis	NOUN
gs-4060	153	14	from	from	ADP
gs-4060	153	15	checkpoint	checkpoint	NOUN
gs-4060	153	16	inhibitors	inhibitor	NOUN
gs-4060	153	17	,	,	PUNCT
gs-4060	153	18	require	require	VERB
gs-4060	153	19	vigilant	vigilant	ADJ
gs-4060	153	20	monitoring	monitoring	NOUN
gs-4060	153	21	and	and	CCONJ
gs-4060	153	22	management	management	NOUN
gs-4060	153	23	strategies	strategy	NOUN
gs-4060	153	24	.	.	PUNCT
gs-4060	154	1	opportunities	opportunity	NOUN
gs-4060	154	2	for	for	ADP
gs-4060	154	3	advancement	advancement	NOUN
gs-4060	154	4	include	include	VERB
gs-4060	154	5	ai	ai	ADJ
gs-4060	154	6	-	-	PUNCT
gs-4060	154	7	driven	drive	VERB
gs-4060	154	8	drug	drug	NOUN
gs-4060	154	9	discovery	discovery	NOUN
gs-4060	154	10	,	,	PUNCT
gs-4060	154	11	which	which	PRON
gs-4060	154	12	accelerates	accelerate	VERB
gs-4060	154	13	the	the	DET
gs-4060	154	14	identification	identification	NOUN
gs-4060	154	15	of	of	ADP
gs-4060	154	16	novel	novel	ADJ
gs-4060	154	17	targets	target	NOUN
gs-4060	154	18	and	and	CCONJ
gs-4060	154	19	optimizes	optimize	VERB
gs-4060	154	20	molecular	molecular	ADJ
gs-4060	154	21	design	design	NOUN
gs-4060	154	22	.	.	PUNCT
gs-4060	155	1	targeting	target	VERB
gs-4060	155	2	cancer	cancer	NOUN
gs-4060	155	3	stem	stem	NOUN
gs-4060	155	4	cells	cell	NOUN
gs-4060	155	5	(	(	PUNCT
gs-4060	155	6	cscs	cscs	PROPN
gs-4060	155	7	)	)	PUNCT
gs-4060	155	8	via	via	ADP
gs-4060	155	9	pathways	pathway	NOUN
gs-4060	155	10	like	like	ADP
gs-4060	155	11	wnt	wnt	PROPN
gs-4060	155	12	,	,	PUNCT
gs-4060	155	13	hedgehog	hedgehog	NOUN
gs-4060	155	14	,	,	PUNCT
gs-4060	155	15	and	and	CCONJ
gs-4060	155	16	notch	notch	NOUN
gs-4060	155	17	offers	offer	VERB
gs-4060	155	18	potential	potential	NOUN
gs-4060	155	19	to	to	PART
gs-4060	155	20	prevent	prevent	VERB
gs-4060	155	21	relapse	relapse	NOUN
gs-4060	155	22	.	.	PUNCT
gs-4060	156	1	additionally	additionally	ADV
gs-4060	156	2	,	,	PUNCT
gs-4060	156	3	the	the	DET
gs-4060	156	4	role	role	NOUN
gs-4060	156	5	of	of	ADP
gs-4060	156	6	the	the	DET
gs-4060	156	7	microbiome	microbiome	NOUN
gs-4060	156	8	in	in	ADP
gs-4060	156	9	modulating	modulate	VERB
gs-4060	156	10	drug	drug	NOUN
gs-4060	156	11	response	response	NOUN
gs-4060	156	12	is	be	AUX
gs-4060	156	13	an	an	DET
gs-4060	156	14	emerging	emerge	VERB
gs-4060	156	15	field	field	NOUN
gs-4060	156	16	,	,	PUNCT
gs-4060	156	17	with	with	ADP
gs-4060	156	18	studies	study	NOUN
gs-4060	156	19	suggesting	suggest	VERB
gs-4060	156	20	that	that	SCONJ
gs-4060	156	21	gut	gut	VERB
gs-4060	156	22	microbiota	microbiota	NOUN
gs-4060	156	23	influence	influence	NOUN
gs-4060	156	24	immunotherapy	immunotherapy	NOUN
gs-4060	156	25	efficacy	efficacy	NOUN
gs-4060	156	26	.	.	PUNCT
gs-4060	157	1	addressing	address	VERB
gs-4060	157	2	global	global	ADJ
gs-4060	157	3	disparities	disparity	NOUN
gs-4060	157	4	in	in	ADP
gs-4060	157	5	access	access	NOUN
gs-4060	157	6	to	to	ADP
gs-4060	157	7	these	these	DET
gs-4060	157	8	therapies	therapy	NOUN
gs-4060	157	9	is	be	AUX
gs-4060	157	10	also	also	ADV
gs-4060	157	11	critical	critical	ADJ
gs-4060	157	12	,	,	PUNCT
gs-4060	157	13	with	with	ADP
gs-4060	157	14	initiatives	initiative	NOUN
gs-4060	157	15	like	like	ADP
gs-4060	157	16	drug	drug	NOUN
gs-4060	157	17	repurposing	repurpose	VERB
gs-4060	157	18	and	and	CCONJ
gs-4060	157	19	biosimilar	biosimilar	ADJ
gs-4060	157	20	development	development	NOUN
gs-4060	157	21	aiming	aim	VERB
gs-4060	157	22	to	to	PART
gs-4060	157	23	reduce	reduce	VERB
gs-4060	157	24	costs	cost	NOUN
gs-4060	157	25	.	.	PUNCT
gs-4060	158	1	cancer	cancer	NOUN
gs-4060	158	2	remains	remain	VERB
gs-4060	158	3	a	a	DET
gs-4060	158	4	formidable	formidable	ADJ
gs-4060	158	5	global	global	ADJ
gs-4060	158	6	health	health	NOUN
gs-4060	158	7	challenge	challenge	NOUN
gs-4060	158	8	,	,	PUNCT
gs-4060	158	9	with	with	ADP
gs-4060	158	10	profound	profound	ADJ
gs-4060	158	11	impacts	impact	NOUN
gs-4060	158	12	on	on	ADP
gs-4060	158	13	morbidity	morbidity	NOUN
gs-4060	158	14	and	and	CCONJ
gs-4060	158	15	mortality	mortality	NOUN
gs-4060	158	16	.	.	PUNCT
gs-4060	159	1	according	accord	VERB
gs-4060	159	2	to	to	ADP
gs-4060	159	3	the	the	DET
gs-4060	159	4	world	world	PROPN
gs-4060	159	5	health	health	PROPN
gs-4060	159	6	organization	organization	PROPN
gs-4060	159	7	,	,	PUNCT
gs-4060	159	8	cancer	cancer	NOUN
gs-4060	159	9	accounted	account	VERB
gs-4060	159	10	for	for	ADP
gs-4060	159	11	approximately	approximately	ADV
gs-4060	159	12	19.3	19.3	NUM
gs-4060	159	13	million	million	NUM
gs-4060	159	14	new	new	ADJ
gs-4060	159	15	cases	case	NOUN
gs-4060	159	16	and	and	CCONJ
gs-4060	159	17	10	10	NUM
gs-4060	159	18	million	million	NUM
gs-4060	159	19	deaths	death	NOUN
gs-4060	159	20	worldwide	worldwide	ADV
gs-4060	159	21	in	in	ADP
gs-4060	159	22	2020	2020	NUM
gs-4060	159	23	,	,	PUNCT
gs-4060	159	24	with	with	ADP
gs-4060	159	25	projections	projection	NOUN
gs-4060	159	26	estimating	estimate	VERB
gs-4060	159	27	a	a	DET
gs-4060	159	28	rise	rise	NOUN
gs-4060	159	29	to	to	ADP
gs-4060	159	30	28.4	28.4	NUM
gs-4060	159	31	million	million	NUM
gs-4060	159	32	new	new	ADJ
gs-4060	159	33	cases	case	NOUN
gs-4060	159	34	by	by	ADP
gs-4060	159	35	2040	2040	NUM
gs-4060	159	36	.	.	PUNCT
gs-4060	160	1	this	this	DET
gs-4060	160	2	escalation	escalation	NOUN
gs-4060	160	3	is	be	AUX
gs-4060	160	4	driven	drive	VERB
gs-4060	160	5	by	by	ADP
gs-4060	160	6	an	an	DET
gs-4060	160	7	aging	age	VERB
gs-4060	160	8	population	population	NOUN
gs-4060	160	9	,	,	PUNCT
gs-4060	160	10	increased	increase	VERB
gs-4060	160	11	prevalence	prevalence	NOUN
gs-4060	160	12	of	of	ADP
gs-4060	160	13	risk	risk	NOUN
gs-4060	160	14	factors	factor	NOUN
gs-4060	160	15	such	such	ADJ
gs-4060	160	16	as	as	ADP
gs-4060	160	17	smoking	smoking	NOUN
gs-4060	160	18	and	and	CCONJ
gs-4060	160	19	obesity	obesity	NOUN
gs-4060	160	20	,	,	PUNCT
gs-4060	160	21	and	and	CCONJ
gs-4060	160	22	environmental	environmental	ADJ
gs-4060	160	23	exposures	exposure	NOUN
gs-4060	160	24	including	include	VERB
gs-4060	160	25	air	air	NOUN
gs-4060	160	26	pollution	pollution	NOUN
gs-4060	160	27	and	and	CCONJ
gs-4060	160	28	occupational	occupational	ADJ
gs-4060	160	29	carcinogens	carcinogen	NOUN
gs-4060	160	30	.	.	PUNCT
gs-4060	161	1	the	the	DET
gs-4060	161	2	complexity	complexity	NOUN
gs-4060	161	3	of	of	ADP
gs-4060	161	4	cancer	cancer	NOUN
gs-4060	161	5	,	,	PUNCT
gs-4060	161	6	characterized	characterize	VERB
gs-4060	161	7	by	by	ADP
gs-4060	161	8	uncontrolled	uncontrolled	ADJ
gs-4060	161	9	cell	cell	NOUN
gs-4060	161	10	growth	growth	NOUN
gs-4060	161	11	,	,	PUNCT
gs-4060	161	12	genetic	genetic	ADJ
gs-4060	161	13	heterogeneity	heterogeneity	NOUN
gs-4060	161	14	,	,	PUNCT
gs-4060	161	15	and	and	CCONJ
gs-4060	161	16	metastatic	metastatic	ADJ
gs-4060	161	17	potential	potential	NOUN
gs-4060	161	18	,	,	PUNCT
gs-4060	161	19	necessitates	necessitate	VERB
gs-4060	161	20	innovative	innovative	ADJ
gs-4060	161	21	therapeutic	therapeutic	ADJ
gs-4060	161	22	strategies	strategy	NOUN
gs-4060	161	23	.	.	PUNCT
gs-4060	162	1	over	over	ADP
gs-4060	162	2	the	the	DET
gs-4060	162	3	past	past	ADJ
gs-4060	162	4	few	few	ADJ
gs-4060	162	5	decades	decade	NOUN
gs-4060	162	6	,	,	PUNCT
gs-4060	162	7	anticancer	anticancer	NOUN
gs-4060	162	8	drug	drug	NOUN
gs-4060	162	9	development	development	NOUN
gs-4060	162	10	has	have	AUX
gs-4060	162	11	transitioned	transition	VERB
gs-4060	162	12	from	from	ADP
gs-4060	162	13	nonspecific	nonspecific	ADJ
gs-4060	162	14	cytotoxic	cytotoxic	ADJ
gs-4060	162	15	agents	agent	NOUN
gs-4060	162	16	to	to	ADP
gs-4060	162	17	highly	highly	ADV
gs-4060	162	18	targeted	target	VERB
gs-4060	162	19	therapies	therapy	NOUN
gs-4060	162	20	,	,	PUNCT
gs-4060	162	21	immunotherapies	immunotherapy	NOUN
gs-4060	162	22	,	,	PUNCT
gs-4060	162	23	and	and	CCONJ
gs-4060	162	24	advanced	advanced	ADJ
gs-4060	162	25	drug	drug	NOUN
gs-4060	162	26	delivery	delivery	NOUN
gs-4060	162	27	systems	system	NOUN
gs-4060	162	28	,	,	PUNCT
gs-4060	162	29	revolutionizing	revolutionize	VERB
gs-4060	162	30	clinical	clinical	ADJ
gs-4060	162	31	management	management	NOUN
gs-4060	162	32	and	and	CCONJ
gs-4060	162	33	patient	patient	ADJ
gs-4060	162	34	outcomes	outcome	NOUN
gs-4060	162	35	.	.	PUNCT
gs-4060	163	1	historically	historically	ADV
gs-4060	163	2	,	,	PUNCT
gs-4060	163	3	the	the	DET
gs-4060	163	4	fight	fight	NOUN
gs-4060	163	5	against	against	ADP
gs-4060	163	6	cancer	cancer	NOUN
gs-4060	163	7	began	begin	VERB
gs-4060	163	8	with	with	ADP
gs-4060	163	9	rudimentary	rudimentary	ADJ
gs-4060	163	10	interventions	intervention	NOUN
gs-4060	163	11	.	.	PUNCT
gs-4060	164	1	in	in	ADP
gs-4060	164	2	the	the	DET
gs-4060	164	3	19th	19th	ADJ
gs-4060	164	4	century	century	NOUN
gs-4060	164	5	,	,	PUNCT
gs-4060	164	6	natural	natural	ADJ
gs-4060	164	7	compounds	compound	NOUN
gs-4060	164	8	like	like	ADP
gs-4060	164	9	podophyllotoxin	podophyllotoxin	NOUN
gs-4060	164	10	from	from	ADP
gs-4060	164	11	podophyllum	podophyllum	PROPN
gs-4060	164	12	peltatum	peltatum	NOUN
gs-4060	164	13	laid	lay	VERB
gs-4060	164	14	the	the	DET
gs-4060	164	15	groundwork	groundwork	NOUN
gs-4060	164	16	for	for	ADP
gs-4060	164	17	modern	modern	ADJ
gs-4060	164	18	chemotherapeutics	chemotherapeutic	NOUN
gs-4060	164	19	such	such	ADJ
gs-4060	164	20	as	as	ADP
gs-4060	164	21	etoposide	etoposide	NOUN
gs-4060	164	22	,	,	PUNCT
gs-4060	164	23	approved	approve	VERB
gs-4060	164	24	in	in	ADP
gs-4060	164	25	1983	1983	NUM
gs-4060	164	26	.	.	PUNCT
gs-4060	165	1	the	the	DET
gs-4060	165	2	mid-20th	mid-20th	NUM
gs-4060	165	3	century	century	NOUN
gs-4060	165	4	saw	see	VERB
gs-4060	165	5	significant	significant	ADJ
gs-4060	165	6	milestones	milestone	NOUN
gs-4060	165	7	with	with	ADP
gs-4060	165	8	the	the	DET
gs-4060	165	9	discovery	discovery	NOUN
gs-4060	165	10	of	of	ADP
gs-4060	165	11	nitrogen	nitrogen	NOUN
gs-4060	165	12	mustards	mustard	NOUN
gs-4060	165	13	during	during	ADP
gs-4060	165	14	world	world	PROPN
gs-4060	165	15	war	war	PROPN
gs-4060	165	16	ii	ii	PROPN
gs-4060	165	17	,	,	PUNCT
gs-4060	165	18	leading	lead	VERB
gs-4060	165	19	to	to	ADP
gs-4060	165	20	alkylating	alkylate	VERB
gs-4060	165	21	agents	agent	NOUN
gs-4060	165	22	like	like	ADP
gs-4060	165	23	cyclophosphamide	cyclophosphamide	NOUN
gs-4060	165	24	.	.	PUNCT
gs-4060	166	1	concurrently	concurrently	ADV
gs-4060	166	2	,	,	PUNCT
gs-4060	166	3	antifolates	antifolate	VERB
gs-4060	166	4	such	such	ADJ
gs-4060	166	5	as	as	ADP
gs-4060	166	6	methotrexate	methotrexate	NOUN
gs-4060	166	7	(	(	PUNCT
gs-4060	166	8	approved	approve	VERB
gs-4060	166	9	in	in	ADP
gs-4060	166	10	1948	1948	NUM
gs-4060	166	11	)	)	PUNCT
gs-4060	166	12	and	and	CCONJ
gs-4060	166	13	antimetabolites	antimetabolite	NOUN
gs-4060	166	14	like	like	ADP
gs-4060	166	15	5	5	NUM
gs-4060	166	16	-	-	PUNCT
gs-4060	166	17	fluorouracil	fluorouracil	NOUN
gs-4060	166	18	(	(	PUNCT
gs-4060	166	19	1950s	1950s	NUM
gs-4060	166	20	)	)	PUNCT
gs-4060	166	21	emerged	emerge	VERB
gs-4060	166	22	,	,	PUNCT
gs-4060	166	23	targeting	target	VERB
gs-4060	166	24	dna	dna	NOUN
gs-4060	166	25	and	and	CCONJ
gs-4060	166	26	rna	rna	NOUN
gs-4060	166	27	synthesis	synthesis	NOUN
gs-4060	166	28	.	.	PUNCT
gs-4060	167	1	plant	plant	NOUN
gs-4060	167	2	-	-	PUNCT
gs-4060	167	3	derived	derive	VERB
gs-4060	167	4	agents	agent	NOUN
gs-4060	167	5	,	,	PUNCT
gs-4060	167	6	including	include	VERB
gs-4060	167	7	vinblastine	vinblastine	NOUN
gs-4060	167	8	in	in	ADP
gs-4060	167	9	the	the	DET
gs-4060	167	10	1960s	1960	NOUN
gs-4060	167	11	and	and	CCONJ
gs-4060	167	12	paclitaxel	paclitaxel	PROPN
gs-4060	167	13	in	in	ADP
gs-4060	167	14	the	the	DET
gs-4060	167	15	1990s	1990	NOUN
gs-4060	167	16	,	,	PUNCT
gs-4060	167	17	further	far	ADV
gs-4060	167	18	expanded	expand	VERB
gs-4060	167	19	the	the	DET
gs-4060	167	20	chemotherapeutic	chemotherapeutic	ADJ
gs-4060	167	21	arsenal	arsenal	NOUN
gs-4060	167	22	.	.	PUNCT
gs-4060	168	1	the	the	DET
gs-4060	168	2	serendipitous	serendipitous	ADJ
gs-4060	168	3	discovery	discovery	NOUN
gs-4060	168	4	of	of	ADP
gs-4060	168	5	cisplatin	cisplatin	NOUN
gs-4060	168	6	in	in	ADP
gs-4060	168	7	1965	1965	NUM
gs-4060	168	8	marked	mark	VERB
gs-4060	168	9	a	a	DET
gs-4060	168	10	georgian	georgian	NOUN
gs-4060	168	11	scientists/	scientists/	NUM
gs-4060	168	12	.	.	PUNCT
gs-4060	169	1	7	7	NUM
gs-4060	169	2	n	n	PRON
gs-4060	169	3	3	3	NUM
gs-4060	169	4	,	,	PUNCT
gs-4060	169	5	2025	2025	NUM
gs-4060	169	6	578	578	NUM
gs-4060	169	7	pivotal	pivotal	ADJ
gs-4060	169	8	advancement	advancement	NOUN
gs-4060	169	9	,	,	PUNCT
gs-4060	169	10	introducing	introduce	VERB
gs-4060	169	11	platinum	platinum	NOUN
gs-4060	169	12	-	-	PUNCT
gs-4060	169	13	based	base	VERB
gs-4060	169	14	drugs	drug	NOUN
gs-4060	169	15	that	that	PRON
gs-4060	169	16	remain	remain	VERB
gs-4060	169	17	cornerstones	cornerstone	NOUN
gs-4060	169	18	in	in	ADP
gs-4060	169	19	treating	treat	VERB
gs-4060	169	20	solid	solid	ADJ
gs-4060	169	21	tumors	tumor	NOUN
gs-4060	169	22	.	.	PUNCT
gs-4060	170	1	the	the	DET
gs-4060	170	2	late	late	ADJ
gs-4060	170	3	1990s	1990	NOUN
gs-4060	170	4	ushered	usher	VERB
gs-4060	170	5	in	in	ADP
gs-4060	170	6	a	a	DET
gs-4060	170	7	paradigm	paradigm	NOUN
gs-4060	170	8	shift	shift	NOUN
gs-4060	170	9	with	with	ADP
gs-4060	170	10	the	the	DET
gs-4060	170	11	advent	advent	NOUN
gs-4060	170	12	of	of	ADP
gs-4060	170	13	targeted	target	VERB
gs-4060	170	14	therapies	therapy	NOUN
gs-4060	170	15	.	.	PUNCT
gs-4060	171	1	the	the	DET
gs-4060	171	2	approval	approval	NOUN
gs-4060	171	3	of	of	ADP
gs-4060	171	4	trastuzumab	trastuzumab	NOUN
gs-4060	171	5	in	in	ADP
gs-4060	171	6	1998	1998	NUM
gs-4060	171	7	for	for	ADP
gs-4060	171	8	her2	her2	NOUN
gs-4060	171	9	-	-	PUNCT
gs-4060	171	10	positive	positive	ADJ
gs-4060	171	11	breast	breast	NOUN
gs-4060	171	12	cancer	cancer	NOUN
gs-4060	171	13	and	and	CCONJ
gs-4060	171	14	imatinib	imatinib	NOUN
gs-4060	171	15	in	in	ADP
gs-4060	171	16	2001	2001	NUM
gs-4060	171	17	for	for	ADP
gs-4060	171	18	chronic	chronic	ADJ
gs-4060	171	19	myelogenous	myelogenous	ADJ
gs-4060	171	20	leukemia	leukemia	NOUN
gs-4060	171	21	(	(	PUNCT
gs-4060	171	22	cml	cml	PROPN
gs-4060	171	23	)	)	PUNCT
gs-4060	171	24	exemplified	exemplify	VERB
gs-4060	171	25	the	the	DET
gs-4060	171	26	potential	potential	NOUN
gs-4060	171	27	of	of	ADP
gs-4060	171	28	precision	precision	NOUN
gs-4060	171	29	medicine	medicine	NOUN
gs-4060	171	30	,	,	PUNCT
gs-4060	171	31	targeting	target	VERB
gs-4060	171	32	specific	specific	ADJ
gs-4060	171	33	molecular	molecular	ADJ
gs-4060	171	34	aberrations	aberration	NOUN
gs-4060	171	35	.	.	PUNCT
gs-4060	172	1	these	these	DET
gs-4060	172	2	successes	success	NOUN
gs-4060	172	3	spurred	spur	VERB
gs-4060	172	4	the	the	DET
gs-4060	172	5	development	development	NOUN
gs-4060	172	6	of	of	ADP
gs-4060	172	7	tyrosine	tyrosine	PROPN
gs-4060	172	8	kinase	kinase	PROPN
gs-4060	172	9	inhibitors	inhibitor	NOUN
gs-4060	172	10	(	(	PUNCT
gs-4060	172	11	tkis	tkis	NOUN
gs-4060	172	12	)	)	PUNCT
gs-4060	172	13	,	,	PUNCT
gs-4060	172	14	monoclonal	monoclonal	NOUN
gs-4060	172	15	antibodies	antibodie	VERB
gs-4060	172	16	,	,	PUNCT
gs-4060	172	17	and	and	CCONJ
gs-4060	172	18	other	other	ADJ
gs-4060	172	19	biologics	biologic	NOUN
gs-4060	172	20	.	.	PUNCT
gs-4060	173	1	by	by	ADP
gs-4060	173	2	2025	2025	NUM
gs-4060	173	3	,	,	PUNCT
gs-4060	173	4	the	the	DET
gs-4060	173	5	therapeutic	therapeutic	ADJ
gs-4060	173	6	landscape	landscape	NOUN
gs-4060	173	7	has	have	AUX
gs-4060	173	8	further	far	ADV
gs-4060	173	9	evolved	evolve	VERB
gs-4060	173	10	with	with	ADP
gs-4060	173	11	the	the	DET
gs-4060	173	12	introduction	introduction	NOUN
gs-4060	173	13	of	of	ADP
gs-4060	173	14	antibody	antibody	NOUN
gs-4060	173	15	-	-	PUNCT
gs-4060	173	16	drug	drug	NOUN
gs-4060	173	17	conjugates	conjugate	NOUN
gs-4060	173	18	(	(	PUNCT
gs-4060	173	19	adcs	adcs	ADJ
gs-4060	173	20	)	)	PUNCT
gs-4060	173	21	,	,	PUNCT
gs-4060	173	22	immune	immune	ADJ
gs-4060	173	23	checkpoint	checkpoint	NOUN
gs-4060	173	24	inhibitors	inhibitor	NOUN
gs-4060	173	25	,	,	PUNCT
gs-4060	173	26	and	and	CCONJ
gs-4060	173	27	chimeric	chimeric	ADJ
gs-4060	173	28	antigen	antigen	ADJ
gs-4060	173	29	receptor	receptor	NOUN
gs-4060	173	30	t	t	NOUN
gs-4060	173	31	-	-	PUNCT
gs-4060	173	32	cell	cell	NOUN
gs-4060	173	33	(	(	PUNCT
gs-4060	173	34	car	car	NOUN
gs-4060	173	35	-	-	PUNCT
gs-4060	173	36	t	t	NOUN
gs-4060	173	37	)	)	PUNCT
gs-4060	173	38	therapies	therapy	NOUN
gs-4060	173	39	,	,	PUNCT
gs-4060	173	40	alongside	alongside	ADP
gs-4060	173	41	novel	novel	ADJ
gs-4060	173	42	approaches	approach	NOUN
gs-4060	173	43	like	like	ADP
gs-4060	173	44	nanotechnology	nanotechnology	NOUN
gs-4060	173	45	and	and	CCONJ
gs-4060	173	46	drug	drug	NOUN
gs-4060	173	47	repurposing	repurposing	NOUN
gs-4060	173	48	.	.	PUNCT
gs-4060	174	1	these	these	DET
gs-4060	174	2	advancements	advancement	NOUN
gs-4060	174	3	aim	aim	VERB
gs-4060	174	4	to	to	PART
gs-4060	174	5	enhance	enhance	VERB
gs-4060	174	6	efficacy	efficacy	NOUN
gs-4060	174	7	,	,	PUNCT
gs-4060	174	8	minimize	minimize	VERB
gs-4060	174	9	offtarget	offtarget	NOUN
gs-4060	174	10	effects	effect	NOUN
gs-4060	174	11	,	,	PUNCT
gs-4060	174	12	and	and	CCONJ
gs-4060	174	13	overcome	overcome	VERB
gs-4060	174	14	resistance	resistance	NOUN
gs-4060	174	15	,	,	PUNCT
gs-4060	174	16	a	a	DET
gs-4060	174	17	persistent	persistent	ADJ
gs-4060	174	18	challenge	challenge	NOUN
gs-4060	174	19	in	in	ADP
gs-4060	174	20	oncology	oncology	NOUN
gs-4060	174	21	.	.	PUNCT
gs-4060	175	1	this	this	DET
gs-4060	175	2	article	article	NOUN
gs-4060	175	3	comprehensively	comprehensively	ADV
gs-4060	175	4	examines	examine	VERB
gs-4060	175	5	the	the	DET
gs-4060	175	6	scientific	scientific	ADJ
gs-4060	175	7	aspects	aspect	NOUN
gs-4060	175	8	of	of	ADP
gs-4060	175	9	new	new	ADJ
gs-4060	175	10	anticancer	anticancer	NOUN
gs-4060	175	11	drugs	drug	NOUN
gs-4060	175	12	,	,	PUNCT
gs-4060	175	13	focusing	focus	VERB
gs-4060	175	14	on	on	ADP
gs-4060	175	15	their	their	PRON
gs-4060	175	16	classification	classification	NOUN
gs-4060	175	17	,	,	PUNCT
gs-4060	175	18	clinical	clinical	ADJ
gs-4060	175	19	use	use	NOUN
gs-4060	175	20	,	,	PUNCT
gs-4060	175	21	features	feature	NOUN
gs-4060	175	22	,	,	PUNCT
gs-4060	175	23	and	and	CCONJ
gs-4060	175	24	mechanisms	mechanism	NOUN
gs-4060	175	25	of	of	ADP
gs-4060	175	26	action	action	NOUN
gs-4060	175	27	,	,	PUNCT
gs-4060	175	28	pharmacology	pharmacology	NOUN
gs-4060	175	29	,	,	PUNCT
gs-4060	175	30	therapeutic	therapeutic	ADJ
gs-4060	175	31	effects	effect	NOUN
gs-4060	175	32	,	,	PUNCT
gs-4060	175	33	and	and	CCONJ
gs-4060	175	34	toxicities	toxicity	NOUN
gs-4060	175	35	.	.	PUNCT
gs-4060	176	1	the	the	DET
gs-4060	176	2	scope	scope	NOUN
gs-4060	176	3	is	be	AUX
gs-4060	176	4	limited	limit	VERB
gs-4060	176	5	to	to	ADP
gs-4060	176	6	drugs	drug	NOUN
gs-4060	176	7	with	with	ADP
gs-4060	176	8	full	full	ADJ
gs-4060	176	9	approval	approval	NOUN
gs-4060	176	10	by	by	ADP
gs-4060	176	11	the	the	DET
gs-4060	176	12	u.s	u.s	PROPN
gs-4060	176	13	.	.	PROPN
gs-4060	176	14	food	food	PROPN
gs-4060	176	15	and	and	CCONJ
gs-4060	176	16	drug	drug	PROPN
gs-4060	176	17	administration	administration	PROPN
gs-4060	176	18	(	(	PUNCT
gs-4060	176	19	fda	fda	PROPN
gs-4060	176	20	)	)	PUNCT
gs-4060	176	21	and	and	CCONJ
gs-4060	176	22	european	european	ADJ
gs-4060	176	23	medicines	medicine	NOUN
gs-4060	176	24	agency	agency	NOUN
gs-4060	176	25	(	(	PUNCT
gs-4060	176	26	ema	ema	PROPN
gs-4060	176	27	)	)	PUNCT
gs-4060	176	28	as	as	ADP
gs-4060	176	29	of	of	ADP
gs-4060	176	30	march	march	PROPN
gs-4060	176	31	2024	2024	NUM
gs-4060	176	32	,	,	PUNCT
gs-4060	176	33	excluding	exclude	VERB
gs-4060	176	34	those	those	PRON
gs-4060	176	35	under	under	ADP
gs-4060	176	36	accelerated	accelerated	ADJ
gs-4060	176	37	or	or	CCONJ
gs-4060	176	38	conditional	conditional	ADJ
gs-4060	176	39	approval	approval	NOUN
gs-4060	176	40	to	to	PART
gs-4060	176	41	ensure	ensure	VERB
gs-4060	176	42	robust	robust	ADJ
gs-4060	176	43	evidence	evidence	NOUN
gs-4060	176	44	of	of	ADP
gs-4060	176	45	clinical	clinical	ADJ
gs-4060	176	46	benefit	benefit	NOUN
gs-4060	176	47	.	.	PUNCT
gs-4060	177	1	the	the	DET
gs-4060	177	2	classification	classification	NOUN
gs-4060	177	3	framework	framework	NOUN
gs-4060	177	4	organizes	organize	VERB
gs-4060	177	5	drugs	drug	NOUN
gs-4060	177	6	by	by	ADP
gs-4060	177	7	their	their	PRON
gs-4060	177	8	site	site	NOUN
gs-4060	177	9	of	of	ADP
gs-4060	177	10	action	action	NOUN
gs-4060	177	11	—	—	PUNCT
gs-4060	177	12	tumor	tumor	NOUN
gs-4060	177	13	cell	cell	NOUN
gs-4060	177	14	nucleus	nucleus	NOUN
gs-4060	177	15	,	,	PUNCT
gs-4060	177	16	cytoplasm	cytoplasm	ADJ
gs-4060	177	17	,	,	PUNCT
gs-4060	177	18	vasculature	vasculature	NOUN
gs-4060	177	19	,	,	PUNCT
gs-4060	177	20	immune	immune	ADJ
gs-4060	177	21	system	system	NOUN
gs-4060	177	22	,	,	PUNCT
gs-4060	177	23	or	or	CCONJ
gs-4060	177	24	endocrine	endocrine	ADJ
gs-4060	177	25	system	system	NOUN
gs-4060	177	26	—	—	PUNCT
gs-4060	177	27	and	and	CCONJ
gs-4060	177	28	their	their	PRON
gs-4060	177	29	mechanistic	mechanistic	ADJ
gs-4060	177	30	approach	approach	NOUN
gs-4060	177	31	,	,	PUNCT
gs-4060	177	32	providing	provide	VERB
gs-4060	177	33	a	a	DET
gs-4060	177	34	structured	structured	ADJ
gs-4060	177	35	understanding	understanding	NOUN
gs-4060	177	36	of	of	ADP
gs-4060	177	37	their	their	PRON
gs-4060	177	38	therapeutic	therapeutic	ADJ
gs-4060	177	39	roles	role	NOUN
gs-4060	177	40	.	.	PUNCT
gs-4060	178	1	this	this	DET
gs-4060	178	2	system	system	NOUN
gs-4060	178	3	facilitates	facilitate	VERB
gs-4060	178	4	the	the	DET
gs-4060	178	5	design	design	NOUN
gs-4060	178	6	of	of	ADP
gs-4060	178	7	rational	rational	ADJ
gs-4060	178	8	combination	combination	NOUN
gs-4060	178	9	therapies	therapy	NOUN
gs-4060	178	10	and	and	CCONJ
gs-4060	178	11	highlights	highlight	NOUN
gs-4060	178	12	synergistic	synergistic	ADJ
gs-4060	178	13	potential	potential	NOUN
gs-4060	178	14	.	.	PUNCT
gs-4060	179	1	emerging	emerge	VERB
gs-4060	179	2	drug	drug	NOUN
gs-4060	179	3	classes	class	NOUN
gs-4060	179	4	,	,	PUNCT
gs-4060	179	5	such	such	ADJ
gs-4060	179	6	as	as	ADP
gs-4060	179	7	adcs	adcs	ADJ
gs-4060	179	8	(	(	PUNCT
gs-4060	179	9	e.g.	e.g.	ADV
gs-4060	179	10	,	,	PUNCT
gs-4060	179	11	trastuzumab	trastuzumab	NOUN
gs-4060	179	12	deruxtecan	deruxtecan	ADJ
gs-4060	179	13	)	)	PUNCT
gs-4060	179	14	,	,	PUNCT
gs-4060	179	15	combine	combine	VERB
gs-4060	179	16	the	the	DET
gs-4060	179	17	specificity	specificity	NOUN
gs-4060	179	18	of	of	ADP
gs-4060	179	19	monoclonal	monoclonal	NOUN
gs-4060	179	20	antibodies	antibody	NOUN
gs-4060	179	21	with	with	ADP
gs-4060	179	22	potent	potent	ADJ
gs-4060	179	23	cytotoxic	cytotoxic	ADJ
gs-4060	179	24	payloads	payload	NOUN
gs-4060	179	25	,	,	PUNCT
gs-4060	179	26	offering	offer	VERB
gs-4060	179	27	improved	improve	VERB
gs-4060	179	28	tumor	tumor	NOUN
gs-4060	179	29	targeting	target	VERB
gs-4060	179	30	.	.	PUNCT
gs-4060	180	1	immune	immune	ADJ
gs-4060	180	2	checkpoint	checkpoint	NOUN
gs-4060	180	3	inhibitors	inhibitor	NOUN
gs-4060	180	4	,	,	PUNCT
gs-4060	180	5	including	include	VERB
gs-4060	180	6	anti	anti	ADJ
gs-4060	180	7	-	-	ADJ
gs-4060	180	8	pd-1	pd-1	ADJ
gs-4060	180	9	/	/	SYM
gs-4060	180	10	pd	pd	ADJ
gs-4060	180	11	-	-	PUNCT
gs-4060	180	12	l1	l1	PROPN
gs-4060	180	13	agents	agent	NOUN
gs-4060	180	14	like	like	ADP
gs-4060	180	15	pembrolizumab	pembrolizumab	NOUN
gs-4060	180	16	and	and	CCONJ
gs-4060	180	17	nivolumab	nivolumab	NOUN
gs-4060	180	18	,	,	PUNCT
gs-4060	180	19	have	have	AUX
gs-4060	180	20	transformed	transform	VERB
gs-4060	180	21	treatment	treatment	NOUN
gs-4060	180	22	for	for	ADP
gs-4060	180	23	cancers	cancer	NOUN
gs-4060	180	24	like	like	ADP
gs-4060	180	25	melanoma	melanoma	NOUN
gs-4060	180	26	and	and	CCONJ
gs-4060	180	27	non	non	ADJ
gs-4060	180	28	-	-	ADJ
gs-4060	180	29	small	small	ADJ
gs-4060	180	30	cell	cell	NOUN
gs-4060	180	31	lung	lung	NOUN
gs-4060	180	32	cancer	cancer	NOUN
gs-4060	180	33	(	(	PUNCT
gs-4060	180	34	nsclc	nsclc	NOUN
gs-4060	180	35	)	)	PUNCT
gs-4060	180	36	by	by	ADP
gs-4060	180	37	unleashing	unleash	VERB
gs-4060	180	38	t	t	PROPN
gs-4060	180	39	-	-	PUNCT
gs-4060	180	40	cell	cell	NOUN
gs-4060	180	41	responses	response	NOUN
gs-4060	180	42	.	.	PUNCT
gs-4060	181	1	tkis	tkis	NOUN
gs-4060	181	2	,	,	PUNCT
gs-4060	181	3	such	such	ADJ
gs-4060	181	4	as	as	ADP
gs-4060	181	5	osimertinib	osimertinib	NOUN
gs-4060	181	6	for	for	ADP
gs-4060	181	7	egfr	egfr	ADV
gs-4060	181	8	-	-	PUNCT
gs-4060	181	9	mutated	mutate	VERB
gs-4060	181	10	nsclc	nsclc	NOUN
gs-4060	181	11	,	,	PUNCT
gs-4060	181	12	target	target	VERB
gs-4060	181	13	specific	specific	ADJ
gs-4060	181	14	oncogenic	oncogenic	ADJ
gs-4060	181	15	pathways	pathway	NOUN
gs-4060	181	16	,	,	PUNCT
gs-4060	181	17	while	while	SCONJ
gs-4060	181	18	natural	natural	ADJ
gs-4060	181	19	products	product	NOUN
gs-4060	181	20	(	(	PUNCT
gs-4060	181	21	e.g.	e.g.	ADV
gs-4060	181	22	,	,	PUNCT
gs-4060	181	23	paclitaxel	paclitaxel	NOUN
gs-4060	181	24	,	,	PUNCT
gs-4060	181	25	curcumin	curcumin	NOUN
gs-4060	181	26	)	)	PUNCT
gs-4060	181	27	and	and	CCONJ
gs-4060	181	28	repurposed	repurpose	VERB
gs-4060	181	29	drugs	drug	NOUN
gs-4060	181	30	(	(	PUNCT
gs-4060	181	31	e.g.	e.g.	ADV
gs-4060	181	32	,	,	PUNCT
gs-4060	181	33	metformin	metformin	NOUN
gs-4060	181	34	,	,	PUNCT
gs-4060	181	35	statins	statin	NOUN
gs-4060	181	36	)	)	PUNCT
gs-4060	181	37	offer	offer	VERB
gs-4060	181	38	cost	cost	NOUN
gs-4060	181	39	-	-	PUNCT
gs-4060	181	40	effective	effective	ADJ
gs-4060	181	41	alternatives	alternative	NOUN
gs-4060	181	42	with	with	ADP
gs-4060	181	43	novel	novel	ADJ
gs-4060	181	44	mechanisms	mechanism	NOUN
gs-4060	181	45	.	.	PUNCT
gs-4060	182	1	advances	advance	NOUN
gs-4060	182	2	in	in	ADP
gs-4060	182	3	drug	drug	NOUN
gs-4060	182	4	delivery	delivery	NOUN
gs-4060	182	5	,	,	PUNCT
gs-4060	182	6	including	include	VERB
gs-4060	182	7	nanoparticles	nanoparticle	NOUN
gs-4060	182	8	,	,	PUNCT
gs-4060	182	9	liposomes	liposome	NOUN
gs-4060	182	10	,	,	PUNCT
gs-4060	182	11	and	and	CCONJ
gs-4060	182	12	microneedles	microneedle	NOUN
gs-4060	182	13	,	,	PUNCT
gs-4060	182	14	address	address	VERB
gs-4060	182	15	challenges	challenge	NOUN
gs-4060	182	16	like	like	ADP
gs-4060	182	17	poor	poor	ADJ
gs-4060	182	18	bioavailability	bioavailability	NOUN
gs-4060	182	19	and	and	CCONJ
gs-4060	182	20	systemic	systemic	ADJ
gs-4060	182	21	toxicity	toxicity	NOUN
gs-4060	182	22	,	,	PUNCT
gs-4060	182	23	enhancing	enhance	VERB
gs-4060	182	24	therapeutic	therapeutic	ADJ
gs-4060	182	25	precision	precision	NOUN
gs-4060	182	26	.	.	PUNCT
gs-4060	183	1	despite	despite	SCONJ
gs-4060	183	2	these	these	DET
gs-4060	183	3	advancements	advancement	NOUN
gs-4060	183	4	,	,	PUNCT
gs-4060	183	5	significant	significant	ADJ
gs-4060	183	6	challenges	challenge	NOUN
gs-4060	183	7	persist	persist	VERB
gs-4060	183	8	.	.	PUNCT
gs-4060	184	1	drug	drug	NOUN
gs-4060	184	2	resistance	resistance	NOUN
gs-4060	184	3	,	,	PUNCT
gs-4060	184	4	driven	drive	VERB
gs-4060	184	5	by	by	ADP
gs-4060	184	6	mechanisms	mechanism	NOUN
gs-4060	184	7	such	such	ADJ
gs-4060	184	8	as	as	ADP
gs-4060	184	9	target	target	NOUN
gs-4060	184	10	mutations	mutation	NOUN
gs-4060	184	11	(	(	PUNCT
gs-4060	184	12	e.g.	e.g.	ADV
gs-4060	184	13	,	,	PUNCT
gs-4060	184	14	egfr	egfr	VERB
gs-4060	184	15	t790	t790	NUM
gs-4060	184	16	m	m	NOUN
gs-4060	184	17	)	)	PUNCT
gs-4060	184	18	,	,	PUNCT
gs-4060	184	19	pathway	pathway	NOUN
gs-4060	184	20	bypassing	bypassing	NOUN
gs-4060	184	21	,	,	PUNCT
gs-4060	184	22	and	and	CCONJ
gs-4060	184	23	tumor	tumor	NOUN
gs-4060	184	24	microenvironment	microenvironment	ADJ
gs-4060	184	25	interactions	interaction	NOUN
gs-4060	184	26	,	,	PUNCT
gs-4060	184	27	limits	limit	VERB
gs-4060	184	28	long	long	ADJ
gs-4060	184	29	-	-	PUNCT
gs-4060	184	30	term	term	NOUN
gs-4060	184	31	efficacy	efficacy	NOUN
gs-4060	184	32	.	.	PUNCT
gs-4060	185	1	toxicities	toxicity	NOUN
gs-4060	185	2	,	,	PUNCT
gs-4060	185	3	ranging	range	VERB
gs-4060	185	4	from	from	ADP
gs-4060	185	5	myelosuppression	myelosuppression	NOUN
gs-4060	185	6	and	and	CCONJ
gs-4060	185	7	cardiotoxicity	cardiotoxicity	NOUN
gs-4060	185	8	to	to	ADP
gs-4060	185	9	immune	immune	NOUN
gs-4060	185	10	-	-	PUNCT
gs-4060	185	11	related	relate	VERB
gs-4060	185	12	adverse	adverse	ADJ
gs-4060	185	13	events	event	NOUN
gs-4060	185	14	,	,	PUNCT
gs-4060	185	15	necessitate	necessitate	ADJ
gs-4060	185	16	careful	careful	ADJ
gs-4060	185	17	management	management	NOUN
gs-4060	185	18	through	through	ADP
gs-4060	185	19	dose	dose	NOUN
gs-4060	185	20	optimization	optimization	NOUN
gs-4060	185	21	,	,	PUNCT
gs-4060	185	22	supportive	supportive	ADJ
gs-4060	185	23	care	care	NOUN
gs-4060	185	24	,	,	PUNCT
gs-4060	185	25	and	and	CCONJ
gs-4060	185	26	pharmacogenomic	pharmacogenomic	ADJ
gs-4060	185	27	profiling	profiling	NOUN
gs-4060	185	28	.	.	PUNCT
gs-4060	186	1	the	the	DET
gs-4060	186	2	high	high	ADJ
gs-4060	186	3	failure	failure	NOUN
gs-4060	186	4	rate	rate	NOUN
gs-4060	186	5	of	of	ADP
gs-4060	186	6	drug	drug	NOUN
gs-4060	186	7	candidates	candidate	NOUN
gs-4060	186	8	—	—	PUNCT
gs-4060	186	9	over	over	ADP
gs-4060	186	10	90	90	NUM
gs-4060	186	11	%	%	NOUN
gs-4060	186	12	due	due	ADP
gs-4060	186	13	to	to	ADP
gs-4060	186	14	insufficient	insufficient	ADJ
gs-4060	186	15	efficacy	efficacy	NOUN
gs-4060	186	16	or	or	CCONJ
gs-4060	186	17	unacceptable	unacceptable	ADJ
gs-4060	186	18	toxicity	toxicity	NOUN
gs-4060	186	19	—	—	PUNCT
gs-4060	186	20	underscores	underscore	VERB
gs-4060	186	21	the	the	DET
gs-4060	186	22	need	need	NOUN
gs-4060	186	23	for	for	ADP
gs-4060	186	24	innovative	innovative	ADJ
gs-4060	186	25	approaches	approach	NOUN
gs-4060	186	26	,	,	PUNCT
gs-4060	186	27	including	include	VERB
gs-4060	186	28	artificial	artificial	ADJ
gs-4060	186	29	intelligence	intelligence	NOUN
gs-4060	186	30	(	(	PUNCT
gs-4060	186	31	ai)-driven	ai)-driven	ADJ
gs-4060	186	32	drug	drug	NOUN
gs-4060	186	33	design	design	NOUN
gs-4060	186	34	,	,	PUNCT
gs-4060	186	35	cancer	cancer	NOUN
gs-4060	186	36	stem	stem	NOUN
gs-4060	186	37	cell	cell	NOUN
gs-4060	186	38	targeting	targeting	NOUN
gs-4060	186	39	,	,	PUNCT
gs-4060	186	40	and	and	CCONJ
gs-4060	186	41	microbiome	microbiome	ADJ
gs-4060	186	42	modulation	modulation	NOUN
gs-4060	186	43	.	.	PUNCT
gs-4060	187	1	the	the	DET
gs-4060	187	2	global	global	ADJ
gs-4060	187	3	burden	burden	NOUN
gs-4060	187	4	of	of	ADP
gs-4060	187	5	cancer	cancer	NOUN
gs-4060	187	6	also	also	ADV
gs-4060	187	7	raises	raise	VERB
gs-4060	187	8	ethical	ethical	ADJ
gs-4060	187	9	and	and	CCONJ
gs-4060	187	10	accessibility	accessibility	NOUN
gs-4060	187	11	concerns	concern	NOUN
gs-4060	187	12	.	.	PUNCT
gs-4060	188	1	high	high	ADJ
gs-4060	188	2	costs	cost	NOUN
gs-4060	188	3	of	of	ADP
gs-4060	188	4	novel	novel	ADJ
gs-4060	188	5	therapies	therapy	NOUN
gs-4060	188	6	,	,	PUNCT
gs-4060	188	7	particularly	particularly	ADV
gs-4060	188	8	biologics	biologic	NOUN
gs-4060	188	9	and	and	CCONJ
gs-4060	188	10	car	car	NOUN
gs-4060	188	11	-	-	PUNCT
gs-4060	188	12	t	t	NOUN
gs-4060	188	13	,	,	PUNCT
gs-4060	188	14	limit	limit	VERB
gs-4060	188	15	access	access	NOUN
gs-4060	188	16	in	in	ADP
gs-4060	188	17	lowand	lowand	ADJ
gs-4060	188	18	middle	middle	ADJ
gs-4060	188	19	-	-	PUNCT
gs-4060	188	20	income	income	NOUN
gs-4060	188	21	countries	country	NOUN
gs-4060	188	22	,	,	PUNCT
gs-4060	188	23	exacerbating	exacerbate	VERB
gs-4060	188	24	health	health	NOUN
gs-4060	188	25	disparities	disparity	NOUN
gs-4060	188	26	.	.	PUNCT
gs-4060	189	1	efforts	effort	NOUN
gs-4060	189	2	to	to	PART
gs-4060	189	3	repurpose	repurpose	VERB
gs-4060	189	4	existing	exist	VERB
gs-4060	189	5	drugs	drug	NOUN
gs-4060	189	6	,	,	PUNCT
gs-4060	189	7	such	such	ADJ
gs-4060	189	8	as	as	ADP
gs-4060	189	9	metformin	metformin	NOUN
gs-4060	189	10	for	for	ADP
gs-4060	189	11	its	its	PRON
gs-4060	189	12	antimetabolic	antimetabolic	ADJ
gs-4060	189	13	effects	effect	NOUN
gs-4060	189	14	or	or	CCONJ
gs-4060	189	15	disulfiram	disulfiram	NOUN
gs-4060	189	16	for	for	ADP
gs-4060	189	17	glycolysis	glycolysis	NOUN
gs-4060	189	18	inhibition	inhibition	NOUN
gs-4060	189	19	,	,	PUNCT
gs-4060	189	20	aim	aim	VERB
gs-4060	189	21	to	to	PART
gs-4060	189	22	provide	provide	VERB
gs-4060	189	23	affordable	affordable	ADJ
gs-4060	189	24	options	option	NOUN
gs-4060	189	25	.	.	PUNCT
gs-4060	190	1	additionally	additionally	ADV
gs-4060	190	2	,	,	PUNCT
gs-4060	190	3	natural	natural	ADJ
gs-4060	190	4	products	product	NOUN
gs-4060	190	5	like	like	ADP
gs-4060	190	6	artemisinin	artemisinin	NOUN
gs-4060	190	7	derivatives	derivative	NOUN
gs-4060	190	8	and	and	CCONJ
gs-4060	190	9	betulinic	betulinic	ADJ
gs-4060	190	10	acid	acid	PROPN
gs-4060	190	11	are	be	AUX
gs-4060	190	12	being	be	AUX
gs-4060	190	13	explored	explore	VERB
gs-4060	190	14	for	for	ADP
gs-4060	190	15	their	their	PRON
gs-4060	190	16	multitargeted	multitargete	VERB
gs-4060	190	17	effects	effect	NOUN
gs-4060	190	18	,	,	PUNCT
gs-4060	190	19	offering	offer	VERB
gs-4060	190	20	potential	potential	NOUN
gs-4060	190	21	in	in	ADP
gs-4060	190	22	resource	resource	NOUN
gs-4060	190	23	-	-	PUNCT
gs-4060	190	24	limited	limit	VERB
gs-4060	190	25	settings	setting	NOUN
gs-4060	190	26	.	.	PUNCT
gs-4060	191	1	georgian	georgian	NOUN
gs-4060	191	2	scientists/	scientists/	NUM
gs-4060	191	3	.	.	PUNCT
gs-4060	192	1	7	7	NUM
gs-4060	192	2	n	n	PRON
gs-4060	192	3	3	3	NUM
gs-4060	192	4	,	,	PUNCT
gs-4060	192	5	2025	2025	NUM
gs-4060	192	6	579	579	NUM
gs-4060	192	7	this	this	DET
gs-4060	192	8	article	article	NOUN
gs-4060	192	9	synthesizes	synthesize	VERB
gs-4060	192	10	current	current	ADJ
gs-4060	192	11	knowledge	knowledge	NOUN
gs-4060	192	12	on	on	ADP
gs-4060	192	13	new	new	ADJ
gs-4060	192	14	anticancer	anticancer	NOUN
gs-4060	192	15	drugs	drug	NOUN
gs-4060	192	16	,	,	PUNCT
gs-4060	192	17	drawing	draw	VERB
gs-4060	192	18	from	from	ADP
gs-4060	192	19	clinical	clinical	ADJ
gs-4060	192	20	trials	trial	NOUN
gs-4060	192	21	,	,	PUNCT
gs-4060	192	22	pharmacological	pharmacological	ADJ
gs-4060	192	23	studies	study	NOUN
gs-4060	192	24	,	,	PUNCT
gs-4060	192	25	and	and	CCONJ
gs-4060	192	26	emerging	emerge	VERB
gs-4060	192	27	trends	trend	NOUN
gs-4060	192	28	up	up	ADV
gs-4060	192	29	to	to	ADP
gs-4060	192	30	2025	2025	NUM
gs-4060	192	31	.	.	PUNCT
gs-4060	193	1	it	it	PRON
gs-4060	193	2	explores	explore	VERB
gs-4060	193	3	how	how	SCONJ
gs-4060	193	4	these	these	DET
gs-4060	193	5	agents	agent	NOUN
gs-4060	193	6	are	be	AUX
gs-4060	193	7	reshaping	reshape	VERB
gs-4060	193	8	oncology	oncology	NOUN
gs-4060	193	9	through	through	ADP
gs-4060	193	10	precision	precision	NOUN
gs-4060	193	11	medicine	medicine	NOUN
gs-4060	193	12	,	,	PUNCT
gs-4060	193	13	while	while	SCONJ
gs-4060	193	14	addressing	address	VERB
gs-4060	193	15	the	the	DET
gs-4060	193	16	scientific	scientific	ADJ
gs-4060	193	17	,	,	PUNCT
gs-4060	193	18	clinical	clinical	ADJ
gs-4060	193	19	,	,	PUNCT
gs-4060	193	20	and	and	CCONJ
gs-4060	193	21	societal	societal	ADJ
gs-4060	193	22	challenges	challenge	NOUN
gs-4060	193	23	that	that	PRON
gs-4060	193	24	remain	remain	VERB
gs-4060	193	25	.	.	PUNCT
gs-4060	194	1	by	by	ADP
gs-4060	194	2	examining	examine	VERB
gs-4060	194	3	the	the	DET
gs-4060	194	4	interplay	interplay	NOUN
gs-4060	194	5	of	of	ADP
gs-4060	194	6	molecular	molecular	ADJ
gs-4060	194	7	mechanisms	mechanism	NOUN
gs-4060	194	8	,	,	PUNCT
gs-4060	194	9	pharmacological	pharmacological	ADJ
gs-4060	194	10	properties	property	NOUN
gs-4060	194	11	,	,	PUNCT
gs-4060	194	12	and	and	CCONJ
gs-4060	194	13	clinical	clinical	ADJ
gs-4060	194	14	outcomes	outcome	NOUN
gs-4060	194	15	,	,	PUNCT
gs-4060	194	16	this	this	DET
gs-4060	194	17	review	review	NOUN
gs-4060	194	18	aims	aim	VERB
gs-4060	194	19	to	to	PART
gs-4060	194	20	provide	provide	VERB
gs-4060	194	21	a	a	DET
gs-4060	194	22	comprehensive	comprehensive	ADJ
gs-4060	194	23	resource	resource	NOUN
gs-4060	194	24	for	for	ADP
gs-4060	194	25	researchers	researcher	NOUN
gs-4060	194	26	,	,	PUNCT
gs-4060	194	27	clinicians	clinician	NOUN
gs-4060	194	28	,	,	PUNCT
gs-4060	194	29	and	and	CCONJ
gs-4060	194	30	policymakers	policymaker	NOUN
gs-4060	194	31	navigating	navigate	VERB
gs-4060	194	32	the	the	DET
gs-4060	194	33	evolving	evolve	VERB
gs-4060	194	34	landscape	landscape	NOUN
gs-4060	194	35	of	of	ADP
gs-4060	194	36	cancer	cancer	NOUN
gs-4060	194	37	therapeutics	therapeutic	NOUN
gs-4060	194	38	.	.	PUNCT
gs-4060	195	1	the	the	DET
gs-4060	195	2	following	follow	VERB
gs-4060	195	3	sections	section	NOUN
gs-4060	195	4	delve	delve	VERB
gs-4060	195	5	into	into	ADP
gs-4060	195	6	the	the	DET
gs-4060	195	7	detailed	detailed	ADJ
gs-4060	195	8	classification	classification	NOUN
gs-4060	195	9	of	of	ADP
gs-4060	195	10	anticancer	anticancer	NOUN
gs-4060	195	11	drugs	drug	NOUN
gs-4060	195	12	,	,	PUNCT
gs-4060	195	13	their	their	PRON
gs-4060	195	14	historical	historical	ADJ
gs-4060	195	15	context	context	NOUN
gs-4060	195	16	,	,	PUNCT
gs-4060	195	17	and	and	CCONJ
gs-4060	195	18	the	the	DET
gs-4060	195	19	scientific	scientific	ADJ
gs-4060	195	20	principles	principle	NOUN
gs-4060	195	21	underpinning	underpin	VERB
gs-4060	195	22	their	their	PRON
gs-4060	195	23	development	development	NOUN
gs-4060	195	24	.	.	PUNCT
gs-4060	196	1	subsequent	subsequent	ADJ
gs-4060	196	2	discussions	discussion	NOUN
gs-4060	196	3	cover	cover	VERB
gs-4060	196	4	specific	specific	ADJ
gs-4060	196	5	mechanisms	mechanism	NOUN
gs-4060	196	6	of	of	ADP
gs-4060	196	7	action	action	NOUN
gs-4060	196	8	,	,	PUNCT
gs-4060	196	9	pharmacological	pharmacological	ADJ
gs-4060	196	10	profiles	profile	NOUN
gs-4060	196	11	,	,	PUNCT
gs-4060	196	12	clinical	clinical	ADJ
gs-4060	196	13	applications	application	NOUN
gs-4060	196	14	,	,	PUNCT
gs-4060	196	15	therapeutic	therapeutic	ADJ
gs-4060	196	16	effects	effect	NOUN
gs-4060	196	17	,	,	PUNCT
gs-4060	196	18	and	and	CCONJ
gs-4060	196	19	toxicity	toxicity	NOUN
gs-4060	196	20	profiles	profile	NOUN
gs-4060	196	21	,	,	PUNCT
gs-4060	196	22	with	with	ADP
gs-4060	196	23	a	a	DET
gs-4060	196	24	focus	focus	NOUN
gs-4060	196	25	on	on	ADP
gs-4060	196	26	recent	recent	ADJ
gs-4060	196	27	innovations	innovation	NOUN
gs-4060	196	28	and	and	CCONJ
gs-4060	196	29	future	future	ADJ
gs-4060	196	30	directions	direction	NOUN
gs-4060	196	31	.	.	PUNCT
gs-4060	197	1	this	this	DET
gs-4060	197	2	holistic	holistic	ADJ
gs-4060	197	3	approach	approach	NOUN
gs-4060	197	4	underscores	underscore	VERB
gs-4060	197	5	the	the	DET
gs-4060	197	6	transformative	transformative	ADJ
gs-4060	197	7	potential	potential	NOUN
gs-4060	197	8	of	of	ADP
gs-4060	197	9	new	new	ADJ
gs-4060	197	10	anticancer	anticancer	NOUN
gs-4060	197	11	drugs	drug	NOUN
gs-4060	197	12	while	while	SCONJ
gs-4060	197	13	acknowledging	acknowledge	VERB
gs-4060	197	14	the	the	DET
gs-4060	197	15	complexities	complexity	NOUN
gs-4060	197	16	of	of	ADP
gs-4060	197	17	translating	translate	VERB
gs-4060	197	18	scientific	scientific	ADJ
gs-4060	197	19	advancements	advancement	NOUN
gs-4060	197	20	into	into	ADP
gs-4060	197	21	equitable	equitable	ADJ
gs-4060	197	22	,	,	PUNCT
gs-4060	197	23	effective	effective	ADJ
gs-4060	197	24	clinical	clinical	ADJ
gs-4060	197	25	practice	practice	NOUN
gs-4060	197	26	.	.	PUNCT
gs-4060	198	1	scope	scope	NOUN
gs-4060	198	2	and	and	CCONJ
gs-4060	198	3	objectives	objective	NOUN
gs-4060	198	4	of	of	ADP
gs-4060	198	5	this	this	DET
gs-4060	198	6	review	review	NOUN
gs-4060	198	7	this	this	DET
gs-4060	198	8	review	review	NOUN
gs-4060	198	9	aims	aim	VERB
gs-4060	198	10	to	to	PART
gs-4060	198	11	provide	provide	VERB
gs-4060	198	12	a	a	DET
gs-4060	198	13	comprehensive	comprehensive	ADJ
gs-4060	198	14	analysis	analysis	NOUN
gs-4060	198	15	of	of	ADP
gs-4060	198	16	new	new	ADJ
gs-4060	198	17	anticancer	anticancer	NOUN
gs-4060	198	18	drugs	drug	NOUN
gs-4060	198	19	,	,	PUNCT
gs-4060	198	20	focusing	focus	VERB
gs-4060	198	21	on	on	ADP
gs-4060	198	22	their	their	PRON
gs-4060	198	23	scientific	scientific	ADJ
gs-4060	198	24	underpinnings	underpinning	NOUN
gs-4060	198	25	and	and	CCONJ
gs-4060	198	26	clinical	clinical	ADJ
gs-4060	198	27	implications	implication	NOUN
gs-4060	198	28	.	.	PUNCT
gs-4060	199	1	by	by	ADP
gs-4060	199	2	classifying	classify	VERB
gs-4060	199	3	drugs	drug	NOUN
gs-4060	199	4	based	base	VERB
gs-4060	199	5	on	on	ADP
gs-4060	199	6	their	their	PRON
gs-4060	199	7	site	site	NOUN
gs-4060	199	8	of	of	ADP
gs-4060	199	9	action	action	NOUN
gs-4060	199	10	and	and	CCONJ
gs-4060	199	11	mechanism	mechanism	NOUN
gs-4060	199	12	,	,	PUNCT
gs-4060	199	13	it	it	PRON
gs-4060	199	14	offers	offer	VERB
gs-4060	199	15	a	a	DET
gs-4060	199	16	framework	framework	NOUN
gs-4060	199	17	for	for	ADP
gs-4060	199	18	understanding	understand	VERB
gs-4060	199	19	their	their	PRON
gs-4060	199	20	therapeutic	therapeutic	ADJ
gs-4060	199	21	roles	role	NOUN
gs-4060	199	22	and	and	CCONJ
gs-4060	199	23	potential	potential	ADJ
gs-4060	199	24	synergies	synergy	NOUN
gs-4060	199	25	.	.	PUNCT
gs-4060	200	1	the	the	DET
gs-4060	200	2	article	article	NOUN
gs-4060	200	3	examines	examine	VERB
gs-4060	200	4	key	key	ADJ
gs-4060	200	5	drug	drug	NOUN
gs-4060	200	6	classes	class	NOUN
gs-4060	200	7	,	,	PUNCT
gs-4060	200	8	including	include	VERB
gs-4060	200	9	adcs	adcs	PROPN
gs-4060	200	10	,	,	PUNCT
gs-4060	200	11	tkis	tkis	PROPN
gs-4060	200	12	,	,	PUNCT
gs-4060	200	13	immunotherapies	immunotherapy	NOUN
gs-4060	200	14	,	,	PUNCT
gs-4060	200	15	natural	natural	ADJ
gs-4060	200	16	products	product	NOUN
gs-4060	200	17	,	,	PUNCT
gs-4060	200	18	and	and	CCONJ
gs-4060	200	19	repurposed	repurposed	ADJ
gs-4060	200	20	agents	agent	NOUN
gs-4060	200	21	,	,	PUNCT
gs-4060	200	22	detailing	detail	VERB
gs-4060	200	23	their	their	PRON
gs-4060	200	24	mechanisms	mechanism	NOUN
gs-4060	200	25	,	,	PUNCT
gs-4060	200	26	pharmacology	pharmacology	NOUN
gs-4060	200	27	,	,	PUNCT
gs-4060	200	28	clinical	clinical	ADJ
gs-4060	200	29	applications	application	NOUN
gs-4060	200	30	,	,	PUNCT
gs-4060	200	31	effects	effect	NOUN
gs-4060	200	32	,	,	PUNCT
gs-4060	200	33	and	and	CCONJ
gs-4060	200	34	toxicities	toxicity	NOUN
gs-4060	200	35	.	.	PUNCT
gs-4060	201	1	it	it	PRON
gs-4060	201	2	also	also	ADV
gs-4060	201	3	explores	explore	VERB
gs-4060	201	4	emerging	emerge	VERB
gs-4060	201	5	approaches	approach	NOUN
gs-4060	201	6	,	,	PUNCT
gs-4060	201	7	such	such	ADJ
gs-4060	201	8	as	as	ADP
gs-4060	201	9	nanotechnology	nanotechnology	NOUN
gs-4060	201	10	and	and	CCONJ
gs-4060	201	11	ai	ai	AUX
gs-4060	201	12	-	-	PUNCT
gs-4060	201	13	driven	drive	VERB
gs-4060	201	14	design	design	NOUN
gs-4060	201	15	,	,	PUNCT
gs-4060	201	16	and	and	CCONJ
gs-4060	201	17	addresses	address	VERB
gs-4060	201	18	future	future	ADJ
gs-4060	201	19	directions	direction	NOUN
gs-4060	201	20	in	in	ADP
gs-4060	201	21	overcoming	overcome	VERB
gs-4060	201	22	resistance	resistance	NOUN
gs-4060	201	23	and	and	CCONJ
gs-4060	201	24	improving	improve	VERB
gs-4060	201	25	accessibility	accessibility	NOUN
gs-4060	201	26	.	.	PUNCT
gs-4060	202	1	through	through	ADP
gs-4060	202	2	this	this	DET
gs-4060	202	3	detailed	detailed	ADJ
gs-4060	202	4	exploration	exploration	NOUN
gs-4060	202	5	,	,	PUNCT
gs-4060	202	6	the	the	DET
gs-4060	202	7	article	article	NOUN
gs-4060	202	8	seeks	seek	VERB
gs-4060	202	9	to	to	PART
gs-4060	202	10	serve	serve	VERB
gs-4060	202	11	as	as	ADP
gs-4060	202	12	a	a	DET
gs-4060	202	13	valuable	valuable	ADJ
gs-4060	202	14	resource	resource	NOUN
gs-4060	202	15	for	for	ADP
gs-4060	202	16	researchers	researcher	NOUN
gs-4060	202	17	,	,	PUNCT
gs-4060	202	18	clinicians	clinician	NOUN
gs-4060	202	19	,	,	PUNCT
gs-4060	202	20	and	and	CCONJ
gs-4060	202	21	policymakers	policymaker	NOUN
gs-4060	202	22	.	.	PUNCT
gs-4060	203	1	it	it	PRON
gs-4060	203	2	highlights	highlight	VERB
gs-4060	203	3	the	the	DET
gs-4060	203	4	transformative	transformative	ADJ
gs-4060	203	5	potential	potential	NOUN
gs-4060	203	6	of	of	ADP
gs-4060	203	7	new	new	ADJ
gs-4060	203	8	anticancer	anticancer	NOUN
gs-4060	203	9	drugs	drug	NOUN
gs-4060	203	10	while	while	SCONJ
gs-4060	203	11	acknowledging	acknowledge	VERB
gs-4060	203	12	the	the	DET
gs-4060	203	13	scientific	scientific	ADJ
gs-4060	203	14	and	and	CCONJ
gs-4060	203	15	societal	societal	ADJ
gs-4060	203	16	challenges	challenge	NOUN
gs-4060	203	17	that	that	PRON
gs-4060	203	18	must	must	AUX
gs-4060	203	19	be	be	AUX
gs-4060	203	20	addressed	address	VERB
gs-4060	203	21	to	to	PART
gs-4060	203	22	realize	realize	VERB
gs-4060	203	23	their	their	PRON
gs-4060	203	24	full	full	ADJ
gs-4060	203	25	impact	impact	NOUN
gs-4060	203	26	in	in	ADP
gs-4060	203	27	the	the	DET
gs-4060	203	28	global	global	ADJ
gs-4060	203	29	fight	fight	NOUN
gs-4060	203	30	against	against	ADP
gs-4060	203	31	cancer	cancer	NOUN
gs-4060	203	32	.	.	PUNCT
gs-4060	204	1	through	through	ADP
gs-4060	204	2	this	this	DET
gs-4060	204	3	detailed	detailed	ADJ
gs-4060	204	4	exploration	exploration	NOUN
gs-4060	204	5	,	,	PUNCT
gs-4060	204	6	the	the	DET
gs-4060	204	7	article	article	NOUN
gs-4060	204	8	seeks	seek	VERB
gs-4060	204	9	to	to	PART
gs-4060	204	10	serve	serve	VERB
gs-4060	204	11	as	as	ADP
gs-4060	204	12	a	a	DET
gs-4060	204	13	valuable	valuable	ADJ
gs-4060	204	14	resource	resource	NOUN
gs-4060	204	15	for	for	ADP
gs-4060	204	16	researchers	researcher	NOUN
gs-4060	204	17	,	,	PUNCT
gs-4060	204	18	clinicians	clinician	NOUN
gs-4060	204	19	,	,	PUNCT
gs-4060	204	20	and	and	CCONJ
gs-4060	204	21	policymakers	policymaker	NOUN
gs-4060	204	22	.	.	PUNCT
gs-4060	205	1	it	it	PRON
gs-4060	205	2	highlights	highlight	VERB
gs-4060	205	3	the	the	DET
gs-4060	205	4	transformative	transformative	ADJ
gs-4060	205	5	potential	potential	NOUN
gs-4060	205	6	of	of	ADP
gs-4060	205	7	new	new	ADJ
gs-4060	205	8	anticancer	anticancer	NOUN
gs-4060	205	9	drugs	drug	NOUN
gs-4060	205	10	while	while	SCONJ
gs-4060	205	11	acknowledging	acknowledge	VERB
gs-4060	205	12	the	the	DET
gs-4060	205	13	scientific	scientific	ADJ
gs-4060	205	14	and	and	CCONJ
gs-4060	205	15	societal	societal	ADJ
gs-4060	205	16	challenges	challenge	NOUN
gs-4060	205	17	that	that	PRON
gs-4060	205	18	must	must	AUX
gs-4060	205	19	be	be	AUX
gs-4060	205	20	addressed	address	VERB
gs-4060	205	21	to	to	PART
gs-4060	205	22	realize	realize	VERB
gs-4060	205	23	their	their	PRON
gs-4060	205	24	full	full	ADJ
gs-4060	205	25	impact	impact	NOUN
gs-4060	205	26	in	in	ADP
gs-4060	205	27	the	the	DET
gs-4060	205	28	global	global	ADJ
gs-4060	205	29	fight	fight	NOUN
gs-4060	205	30	against	against	ADP
gs-4060	205	31	cancer	cancer	NOUN
gs-4060	205	32	.	.	PUNCT
gs-4060	206	1	to	to	PART
gs-4060	206	2	further	far	ADV
gs-4060	206	3	elaborate	elaborate	VERB
gs-4060	206	4	on	on	ADP
gs-4060	206	5	the	the	DET
gs-4060	206	6	historical	historical	ADJ
gs-4060	206	7	evolution	evolution	NOUN
gs-4060	206	8	,	,	PUNCT
gs-4060	206	9	let	let	VERB
gs-4060	206	10	's	us	PRON
gs-4060	206	11	consider	consider	VERB
gs-4060	206	12	the	the	DET
gs-4060	206	13	role	role	NOUN
gs-4060	206	14	of	of	ADP
gs-4060	206	15	key	key	ADJ
gs-4060	206	16	discoveries	discovery	NOUN
gs-4060	206	17	in	in	ADP
gs-4060	206	18	shaping	shape	VERB
gs-4060	206	19	current	current	ADJ
gs-4060	206	20	therapies	therapy	NOUN
gs-4060	206	21	.	.	PUNCT
gs-4060	207	1	the	the	DET
gs-4060	207	2	identification	identification	NOUN
gs-4060	207	3	of	of	ADP
gs-4060	207	4	the	the	DET
gs-4060	207	5	philadelphia	philadelphia	PROPN
gs-4060	207	6	chromosome	chromosome	NOUN
gs-4060	207	7	in	in	ADP
gs-4060	207	8	1960	1960	NUM
gs-4060	207	9	led	lead	VERB
gs-4060	207	10	to	to	ADP
gs-4060	207	11	the	the	DET
gs-4060	207	12	understanding	understanding	NOUN
gs-4060	207	13	of	of	ADP
gs-4060	207	14	bcr	bcr	PROPN
gs-4060	207	15	-	-	ADJ
gs-4060	207	16	abl	abl	NOUN
gs-4060	207	17	fusion	fusion	NOUN
gs-4060	207	18	in	in	ADP
gs-4060	207	19	cml	cml	PROPN
gs-4060	207	20	,	,	PUNCT
gs-4060	207	21	culminating	culminate	VERB
gs-4060	207	22	in	in	ADP
gs-4060	207	23	imatinib	imatinib	NOUN
gs-4060	207	24	's	's	PART
gs-4060	207	25	approval	approval	NOUN
gs-4060	207	26	.	.	PUNCT
gs-4060	208	1	similarly	similarly	ADV
gs-4060	208	2	,	,	PUNCT
gs-4060	208	3	the	the	DET
gs-4060	208	4	discovery	discovery	NOUN
gs-4060	208	5	of	of	ADP
gs-4060	208	6	egfr	egfr	ADJ
gs-4060	208	7	mutations	mutation	NOUN
gs-4060	208	8	in	in	ADP
gs-4060	208	9	nsclc	nsclc	NOUN
gs-4060	208	10	in	in	ADP
gs-4060	208	11	2004	2004	NUM
gs-4060	208	12	paved	pave	VERB
gs-4060	208	13	the	the	DET
gs-4060	208	14	way	way	NOUN
gs-4060	208	15	for	for	ADP
gs-4060	208	16	gefitinib	gefitinib	NOUN
gs-4060	208	17	and	and	CCONJ
gs-4060	208	18	erlotinib	erlotinib	NOUN
gs-4060	208	19	.	.	PUNCT
gs-4060	209	1	these	these	DET
gs-4060	209	2	examples	example	NOUN
gs-4060	209	3	illustrate	illustrate	VERB
gs-4060	209	4	how	how	SCONJ
gs-4060	209	5	basic	basic	ADJ
gs-4060	209	6	science	science	NOUN
gs-4060	209	7	translates	translate	VERB
gs-4060	209	8	to	to	ADP
gs-4060	209	9	clinical	clinical	ADJ
gs-4060	209	10	breakthroughs	breakthrough	NOUN
gs-4060	209	11	.	.	PUNCT
gs-4060	210	1	in	in	ADP
gs-4060	210	2	the	the	DET
gs-4060	210	3	context	context	NOUN
gs-4060	210	4	of	of	ADP
gs-4060	210	5	immunotherapies	immunotherapy	NOUN
gs-4060	210	6	,	,	PUNCT
gs-4060	210	7	the	the	DET
gs-4060	210	8	nobel	nobel	PROPN
gs-4060	210	9	prize	prize	NOUN
gs-4060	210	10	-	-	PUNCT
gs-4060	210	11	winning	win	VERB
gs-4060	210	12	work	work	NOUN
gs-4060	210	13	on	on	ADP
gs-4060	210	14	immune	immune	ADJ
gs-4060	210	15	checkpoints	checkpoint	NOUN
gs-4060	210	16	by	by	ADP
gs-4060	210	17	honjo	honjo	NOUN
gs-4060	210	18	and	and	CCONJ
gs-4060	210	19	allison	allison	PROPN
gs-4060	210	20	in	in	ADP
gs-4060	210	21	2018	2018	NUM
gs-4060	210	22	has	have	AUX
gs-4060	210	23	led	lead	VERB
gs-4060	210	24	to	to	ADP
gs-4060	210	25	widespread	widespread	ADJ
gs-4060	210	26	adoption	adoption	NOUN
gs-4060	210	27	of	of	ADP
gs-4060	210	28	pd-1	pd-1	ADJ
gs-4060	210	29	inhibitors	inhibitor	NOUN
gs-4060	210	30	.	.	PUNCT
gs-4060	211	1	the	the	DET
gs-4060	211	2	success	success	NOUN
gs-4060	211	3	of	of	ADP
gs-4060	211	4	sipuleucel	sipuleucel	NOUN
gs-4060	211	5	-	-	PUNCT
gs-4060	211	6	t	t	NOUN
gs-4060	211	7	in	in	ADP
gs-4060	211	8	2010	2010	NUM
gs-4060	211	9	as	as	ADP
gs-4060	211	10	the	the	DET
gs-4060	211	11	first	first	ADJ
gs-4060	211	12	cancer	cancer	NOUN
gs-4060	211	13	vaccine	vaccine	NOUN
gs-4060	211	14	set	set	VERB
gs-4060	211	15	the	the	DET
gs-4060	211	16	stage	stage	NOUN
gs-4060	211	17	for	for	ADP
gs-4060	211	18	personalized	personalize	VERB
gs-4060	211	19	neoantigen	neoantigen	NOUN
gs-4060	211	20	vaccines	vaccine	NOUN
gs-4060	211	21	,	,	PUNCT
gs-4060	211	22	now	now	ADV
gs-4060	211	23	in	in	ADP
gs-4060	211	24	advanced	advanced	ADJ
gs-4060	211	25	trials	trial	NOUN
gs-4060	211	26	.	.	PUNCT
gs-4060	212	1	these	these	DET
gs-4060	212	2	developments	development	NOUN
gs-4060	212	3	underscore	underscore	VERB
gs-4060	212	4	the	the	DET
gs-4060	212	5	shift	shift	NOUN
gs-4060	212	6	from	from	ADP
gs-4060	212	7	empirical	empirical	ADJ
gs-4060	212	8	to	to	ADP
gs-4060	212	9	mechanismbased	mechanismbase	VERB
gs-4060	212	10	drug	drug	NOUN
gs-4060	212	11	design	design	NOUN
gs-4060	212	12	.	.	PUNCT
gs-4060	213	1	moving	move	VERB
gs-4060	213	2	to	to	ADP
gs-4060	213	3	targeted	target	VERB
gs-4060	213	4	therapies	therapy	NOUN
gs-4060	213	5	,	,	PUNCT
gs-4060	213	6	the	the	DET
gs-4060	213	7	approval	approval	NOUN
gs-4060	213	8	of	of	ADP
gs-4060	213	9	parp	parp	ADJ
gs-4060	213	10	inhibitors	inhibitor	NOUN
gs-4060	213	11	like	like	ADP
gs-4060	213	12	olaparib	olaparib	NOUN
gs-4060	213	13	in	in	ADP
gs-4060	213	14	2014	2014	NUM
gs-4060	213	15	for	for	ADP
gs-4060	213	16	brca	brca	PROPN
gs-4060	213	17	-	-	PUNCT
gs-4060	213	18	mutated	mutate	VERB
gs-4060	213	19	cancers	cancer	NOUN
gs-4060	213	20	exploited	exploit	VERB
gs-4060	213	21	synthetic	synthetic	ADJ
gs-4060	213	22	lethality	lethality	NOUN
gs-4060	213	23	,	,	PUNCT
gs-4060	213	24	a	a	DET
gs-4060	213	25	concept	concept	NOUN
gs-4060	213	26	rooted	root	VERB
gs-4060	213	27	in	in	ADP
gs-4060	213	28	genetic	genetic	ADJ
gs-4060	213	29	interactions	interaction	NOUN
gs-4060	213	30	.	.	PUNCT
gs-4060	214	1	this	this	DET
gs-4060	214	2	georgian	georgian	NOUN
gs-4060	214	3	scientists/	scientists/	NUM
gs-4060	214	4	.	.	PUNCT
gs-4060	215	1	7	7	NUM
gs-4060	215	2	n	n	PRON
gs-4060	215	3	3	3	NUM
gs-4060	215	4	,	,	PUNCT
gs-4060	215	5	2025	2025	NUM
gs-4060	215	6	580	580	NUM
gs-4060	215	7	has	have	AUX
gs-4060	215	8	expanded	expand	VERB
gs-4060	215	9	to	to	ADP
gs-4060	215	10	other	other	ADJ
gs-4060	215	11	dna	dna	PROPN
gs-4060	215	12	repair	repair	NOUN
gs-4060	215	13	inhibitors	inhibitor	NOUN
gs-4060	215	14	,	,	PUNCT
gs-4060	215	15	highlighting	highlight	VERB
gs-4060	215	16	the	the	DET
gs-4060	215	17	importance	importance	NOUN
gs-4060	215	18	of	of	ADP
gs-4060	215	19	biomarker	biomarker	NOUN
gs-4060	215	20	-	-	PUNCT
gs-4060	215	21	driven	drive	VERB
gs-4060	215	22	approaches	approach	NOUN
gs-4060	215	23	.	.	PUNCT
gs-4060	216	1	for	for	ADP
gs-4060	216	2	adcs	adcs	ADJ
gs-4060	216	3	,	,	PUNCT
gs-4060	216	4	the	the	DET
gs-4060	216	5	evolution	evolution	NOUN
gs-4060	216	6	from	from	ADP
gs-4060	216	7	gemtuzumab	gemtuzumab	NOUN
gs-4060	216	8	ozogamicin	ozogamicin	ADV
gs-4060	216	9	in	in	ADP
gs-4060	216	10	2000	2000	NUM
gs-4060	216	11	to	to	ADP
gs-4060	216	12	modern	modern	ADJ
gs-4060	216	13	agents	agent	NOUN
gs-4060	216	14	like	like	ADP
gs-4060	216	15	enfortumab	enfortumab	X
gs-4060	216	16	vedotin	vedotin	ADJ
gs-4060	216	17	demonstrates	demonstrate	VERB
gs-4060	216	18	improvements	improvement	NOUN
gs-4060	216	19	in	in	ADP
gs-4060	216	20	linker	linker	NOUN
gs-4060	216	21	technology	technology	NOUN
gs-4060	216	22	and	and	CCONJ
gs-4060	216	23	payload	payload	ADJ
gs-4060	216	24	potency	potency	NOUN
gs-4060	216	25	,	,	PUNCT
gs-4060	216	26	reducing	reduce	VERB
gs-4060	216	27	toxicity	toxicity	NOUN
gs-4060	216	28	while	while	SCONJ
gs-4060	216	29	enhancing	enhance	VERB
gs-4060	216	30	efficacy	efficacy	NOUN
gs-4060	216	31	.	.	PUNCT
gs-4060	217	1	repurposed	repurpose	VERB
gs-4060	217	2	drugs	drug	NOUN
gs-4060	217	3	represent	represent	VERB
gs-4060	217	4	a	a	DET
gs-4060	217	5	cost	cost	NOUN
gs-4060	217	6	-	-	PUNCT
gs-4060	217	7	effective	effective	ADJ
gs-4060	217	8	strategy	strategy	NOUN
gs-4060	217	9	.	.	PUNCT
gs-4060	218	1	metformin	metformin	NOUN
gs-4060	218	2	,	,	PUNCT
gs-4060	218	3	originally	originally	ADV
gs-4060	218	4	for	for	ADP
gs-4060	218	5	diabetes	diabetes	NOUN
gs-4060	218	6	,	,	PUNCT
gs-4060	218	7	inhibits	inhibit	VERB
gs-4060	218	8	mtor	mtor	PROPN
gs-4060	218	9	signaling	signaling	NOUN
gs-4060	218	10	,	,	PUNCT
gs-4060	218	11	showing	show	VERB
gs-4060	218	12	promise	promise	NOUN
gs-4060	218	13	in	in	ADP
gs-4060	218	14	breast	breast	NOUN
gs-4060	218	15	cancer	cancer	NOUN
gs-4060	218	16	trials	trial	NOUN
gs-4060	218	17	.	.	PUNCT
gs-4060	219	1	aspirin	aspirin	NOUN
gs-4060	219	2	reduces	reduce	VERB
gs-4060	219	3	colorectal	colorectal	ADJ
gs-4060	219	4	cancer	cancer	NOUN
gs-4060	219	5	risk	risk	NOUN
gs-4060	219	6	through	through	ADP
gs-4060	219	7	cox	cox	PROPN
gs-4060	219	8	inhibition	inhibition	NOUN
gs-4060	219	9	,	,	PUNCT
gs-4060	219	10	illustrating	illustrate	VERB
gs-4060	219	11	how	how	SCONJ
gs-4060	219	12	existing	exist	VERB
gs-4060	219	13	drugs	drug	NOUN
gs-4060	219	14	can	can	AUX
gs-4060	219	15	be	be	AUX
gs-4060	219	16	leveraged	leverage	VERB
gs-4060	219	17	for	for	ADP
gs-4060	219	18	oncology	oncology	NOUN
gs-4060	219	19	.	.	PUNCT
gs-4060	220	1	natural	natural	ADJ
gs-4060	220	2	products	product	NOUN
gs-4060	220	3	continue	continue	VERB
gs-4060	220	4	to	to	PART
gs-4060	220	5	inspire	inspire	VERB
gs-4060	220	6	.	.	PUNCT
gs-4060	221	1	taxanes	taxane	NOUN
gs-4060	221	2	from	from	ADP
gs-4060	221	3	yew	yew	PROPN
gs-4060	221	4	trees	tree	NOUN
gs-4060	221	5	and	and	CCONJ
gs-4060	221	6	vinca	vinca	ADJ
gs-4060	221	7	alkaloids	alkaloid	NOUN
gs-4060	221	8	from	from	ADP
gs-4060	221	9	periwinkle	periwinkle	NOUN
gs-4060	221	10	plants	plant	NOUN
gs-4060	221	11	remain	remain	VERB
gs-4060	221	12	staples	staple	NOUN
gs-4060	221	13	,	,	PUNCT
gs-4060	221	14	with	with	ADP
gs-4060	221	15	new	new	ADJ
gs-4060	221	16	derivatives	derivative	NOUN
gs-4060	221	17	like	like	ADP
gs-4060	221	18	cabazitaxel	cabazitaxel	NOUN
gs-4060	221	19	addressing	address	VERB
gs-4060	221	20	resistance	resistance	NOUN
gs-4060	221	21	.	.	PUNCT
gs-4060	222	1	drug	drug	NOUN
gs-4060	222	2	delivery	delivery	NOUN
gs-4060	222	3	innovations	innovation	NOUN
gs-4060	222	4	,	,	PUNCT
gs-4060	222	5	such	such	ADJ
gs-4060	222	6	as	as	ADP
gs-4060	222	7	liposomal	liposomal	ADJ
gs-4060	222	8	doxorubicin	doxorubicin	PROPN
gs-4060	222	9	,	,	PUNCT
gs-4060	222	10	reduce	reduce	VERB
gs-4060	222	11	cardiotoxicity	cardiotoxicity	NOUN
gs-4060	222	12	by	by	ADP
gs-4060	222	13	altering	alter	VERB
gs-4060	222	14	pharmacokinetics	pharmacokinetic	NOUN
gs-4060	222	15	.	.	PUNCT
gs-4060	223	1	nanotechnology	nanotechnology	NOUN
gs-4060	223	2	enables	enable	VERB
gs-4060	223	3	tumor	tumor	NOUN
gs-4060	223	4	-	-	PUNCT
gs-4060	223	5	specific	specific	ADJ
gs-4060	223	6	accumulation	accumulation	NOUN
gs-4060	223	7	via	via	ADP
gs-4060	223	8	the	the	DET
gs-4060	223	9	enhanced	enhanced	ADJ
gs-4060	223	10	permeability	permeability	NOUN
gs-4060	223	11	and	and	CCONJ
gs-4060	223	12	retention	retention	NOUN
gs-4060	223	13	effect	effect	NOUN
gs-4060	223	14	.	.	PUNCT
gs-4060	224	1	challenges	challenge	NOUN
gs-4060	224	2	in	in	ADP
gs-4060	224	3	drug	drug	NOUN
gs-4060	224	4	development	development	NOUN
gs-4060	224	5	include	include	VERB
gs-4060	224	6	high	high	ADJ
gs-4060	224	7	attrition	attrition	NOUN
gs-4060	224	8	rates	rate	NOUN
gs-4060	224	9	,	,	PUNCT
gs-4060	224	10	with	with	ADP
gs-4060	224	11	only	only	ADV
gs-4060	224	12	5	5	NUM
gs-4060	224	13	%	%	NOUN
gs-4060	224	14	of	of	ADP
gs-4060	224	15	oncology	oncology	NOUN
gs-4060	224	16	candidates	candidate	NOUN
gs-4060	224	17	reaching	reach	VERB
gs-4060	224	18	approval	approval	NOUN
gs-4060	224	19	.	.	PUNCT
gs-4060	225	1	regulatory	regulatory	ADJ
gs-4060	225	2	pathways	pathway	NOUN
gs-4060	225	3	like	like	ADP
gs-4060	225	4	fda	fda	PROPN
gs-4060	225	5	's	's	PART
gs-4060	225	6	accelerated	accelerate	VERB
gs-4060	225	7	approval	approval	NOUN
gs-4060	225	8	facilitate	facilitate	NOUN
gs-4060	225	9	faster	fast	ADJ
gs-4060	225	10	access	access	NOUN
gs-4060	225	11	but	but	CCONJ
gs-4060	225	12	require	require	VERB
gs-4060	225	13	post	post	ADJ
gs-4060	225	14	-	-	ADJ
gs-4060	225	15	marketing	marketing	ADJ
gs-4060	225	16	confirmation	confirmation	NOUN
gs-4060	225	17	.	.	PUNCT
gs-4060	226	1	global	global	ADJ
gs-4060	226	2	disparities	disparity	NOUN
gs-4060	226	3	are	be	AUX
gs-4060	226	4	stark	stark	ADJ
gs-4060	226	5	,	,	PUNCT
gs-4060	226	6	with	with	ADP
gs-4060	226	7	70	70	NUM
gs-4060	226	8	%	%	NOUN
gs-4060	226	9	of	of	ADP
gs-4060	226	10	cancer	cancer	NOUN
gs-4060	226	11	deaths	death	NOUN
gs-4060	226	12	in	in	ADP
gs-4060	226	13	low	low	ADJ
gs-4060	226	14	-	-	PUNCT
gs-4060	226	15	income	income	NOUN
gs-4060	226	16	countries	country	NOUN
gs-4060	226	17	.	.	PUNCT
gs-4060	227	1	initiatives	initiative	NOUN
gs-4060	227	2	like	like	ADP
gs-4060	227	3	the	the	PRON
gs-4060	227	4	who	who	PRON
gs-4060	227	5	's	be	AUX
gs-4060	227	6	global	global	ADJ
gs-4060	227	7	medicine	medicine	NOUN
gs-4060	227	8	access	access	NOUN
gs-4060	227	9	program	program	NOUN
gs-4060	227	10	aim	aim	VERB
gs-4060	227	11	to	to	PART
gs-4060	227	12	bridge	bridge	VERB
gs-4060	227	13	this	this	DET
gs-4060	227	14	gap	gap	NOUN
gs-4060	227	15	.	.	PUNCT
gs-4060	228	1	goals	goal	NOUN
gs-4060	228	2	the	the	DET
gs-4060	228	3	primary	primary	ADJ
gs-4060	228	4	aim	aim	NOUN
gs-4060	228	5	of	of	ADP
gs-4060	228	6	this	this	DET
gs-4060	228	7	comprehensive	comprehensive	ADJ
gs-4060	228	8	review	review	NOUN
gs-4060	228	9	is	be	AUX
gs-4060	228	10	to	to	PART
gs-4060	228	11	provide	provide	VERB
gs-4060	228	12	a	a	DET
gs-4060	228	13	detailed	detailed	ADJ
gs-4060	228	14	and	and	CCONJ
gs-4060	228	15	systematic	systematic	ADJ
gs-4060	228	16	examination	examination	NOUN
gs-4060	228	17	of	of	ADP
gs-4060	228	18	the	the	DET
gs-4060	228	19	new	new	ADJ
gs-4060	228	20	generation	generation	NOUN
gs-4060	228	21	of	of	ADP
gs-4060	228	22	anticancer	anticancer	NOUN
gs-4060	228	23	therapeutics	therapeutic	NOUN
gs-4060	228	24	.	.	PUNCT
gs-4060	229	1	to	to	PART
gs-4060	229	2	achieve	achieve	VERB
gs-4060	229	3	this	this	DET
gs-4060	229	4	overarching	overarching	ADJ
gs-4060	229	5	aim	aim	NOUN
gs-4060	229	6	,	,	PUNCT
gs-4060	229	7	we	we	PRON
gs-4060	229	8	have	have	AUX
gs-4060	229	9	established	establish	VERB
gs-4060	229	10	the	the	DET
gs-4060	229	11	following	follow	VERB
gs-4060	229	12	specific	specific	ADJ
gs-4060	229	13	goals	goal	NOUN
gs-4060	229	14	:	:	PUNCT
gs-4060	229	15	to	to	PART
gs-4060	229	16	establish	establish	VERB
gs-4060	229	17	a	a	DET
gs-4060	229	18	modern	modern	ADJ
gs-4060	229	19	classification	classification	NOUN
gs-4060	229	20	framework	framework	NOUN
gs-4060	229	21	:	:	PUNCT
gs-4060	229	22	to	to	PART
gs-4060	229	23	move	move	VERB
gs-4060	229	24	beyond	beyond	ADP
gs-4060	229	25	traditional	traditional	ADJ
gs-4060	229	26	chemotherapybased	chemotherapybase	VERB
gs-4060	229	27	classification	classification	NOUN
gs-4060	229	28	and	and	CCONJ
gs-4060	229	29	propose	propose	VERB
gs-4060	229	30	a	a	DET
gs-4060	229	31	coherent	coherent	ADJ
gs-4060	229	32	,	,	PUNCT
gs-4060	229	33	mechanism	mechanism	NOUN
gs-4060	229	34	-	-	PUNCT
gs-4060	229	35	driven	drive	VERB
gs-4060	229	36	taxonomy	taxonomy	NOUN
gs-4060	229	37	that	that	PRON
gs-4060	229	38	accurately	accurately	ADV
gs-4060	229	39	categorizes	categorize	VERB
gs-4060	229	40	novel	novel	ADJ
gs-4060	229	41	anticancer	anticancer	NOUN
gs-4060	229	42	drugs	drug	NOUN
gs-4060	229	43	into	into	ADP
gs-4060	229	44	logical	logical	ADJ
gs-4060	229	45	groups	group	NOUN
gs-4060	229	46	such	such	ADJ
gs-4060	229	47	as	as	ADP
gs-4060	229	48	targeted	target	VERB
gs-4060	229	49	therapies	therapy	NOUN
gs-4060	229	50	(	(	PUNCT
gs-4060	229	51	e.g.	e.g.	ADV
gs-4060	229	52	,	,	PUNCT
gs-4060	229	53	small	small	ADJ
gs-4060	229	54	molecule	molecule	NOUN
gs-4060	229	55	inhibitors	inhibitor	NOUN
gs-4060	229	56	,	,	PUNCT
gs-4060	229	57	monoclonal	monoclonal	NOUN
gs-4060	229	58	antibodies	antibody	NOUN
gs-4060	229	59	)	)	PUNCT
gs-4060	229	60	and	and	CCONJ
gs-4060	229	61	immunotherapies	immunotherapy	NOUN
gs-4060	229	62	(	(	PUNCT
gs-4060	229	63	e.g.	e.g.	ADV
gs-4060	229	64	,	,	PUNCT
gs-4060	229	65	checkpoint	checkpoint	NOUN
gs-4060	229	66	inhibitors	inhibitor	NOUN
gs-4060	229	67	,	,	PUNCT
gs-4060	229	68	car	car	NOUN
gs-4060	229	69	-	-	PUNCT
gs-4060	229	70	t	t	NOUN
gs-4060	229	71	cells	cell	NOUN
gs-4060	229	72	,	,	PUNCT
gs-4060	229	73	cancer	cancer	NOUN
gs-4060	229	74	vaccines	vaccine	NOUN
gs-4060	229	75	)	)	PUNCT
gs-4060	229	76	,	,	PUNCT
gs-4060	229	77	including	include	VERB
gs-4060	229	78	their	their	PRON
gs-4060	229	79	respective	respective	ADJ
gs-4060	229	80	subclasses	subclass	NOUN
gs-4060	229	81	.	.	PUNCT
gs-4060	230	1	to	to	PART
gs-4060	230	2	delineate	delineate	VERB
gs-4060	230	3	precise	precise	ADJ
gs-4060	230	4	mechanisms	mechanism	NOUN
gs-4060	230	5	of	of	ADP
gs-4060	230	6	action	action	NOUN
gs-4060	230	7	:	:	PUNCT
gs-4060	230	8	to	to	PART
gs-4060	230	9	elucidate	elucidate	VERB
gs-4060	230	10	the	the	DET
gs-4060	230	11	molecular	molecular	ADJ
gs-4060	230	12	and	and	CCONJ
gs-4060	230	13	cellular	cellular	ADJ
gs-4060	230	14	mechanisms	mechanism	NOUN
gs-4060	230	15	by	by	ADP
gs-4060	230	16	which	which	PRON
gs-4060	230	17	these	these	DET
gs-4060	230	18	new	new	ADJ
gs-4060	230	19	agents	agent	NOUN
gs-4060	230	20	exert	exert	VERB
gs-4060	230	21	their	their	PRON
gs-4060	230	22	antitumor	antitumor	PROPN
gs-4060	230	23	effects	effect	NOUN
gs-4060	230	24	.	.	PUNCT
gs-4060	231	1	this	this	PRON
gs-4060	231	2	includes	include	VERB
gs-4060	231	3	detailed	detailed	ADJ
gs-4060	231	4	explanations	explanation	NOUN
gs-4060	231	5	of	of	ADP
gs-4060	231	6	how	how	SCONJ
gs-4060	231	7	they	they	PRON
gs-4060	231	8	interact	interact	VERB
gs-4060	231	9	with	with	ADP
gs-4060	231	10	specific	specific	ADJ
gs-4060	231	11	targets	target	NOUN
gs-4060	231	12	,	,	PUNCT
gs-4060	231	13	disrupt	disrupt	VERB
gs-4060	231	14	critical	critical	ADJ
gs-4060	231	15	signaling	signal	VERB
gs-4060	231	16	pathways	pathway	NOUN
gs-4060	231	17	(	(	PUNCT
gs-4060	231	18	e.g.	e.g.	ADV
gs-4060	231	19	,	,	PUNCT
gs-4060	231	20	mapk	mapk	NOUN
gs-4060	231	21	,	,	PUNCT
gs-4060	231	22	pi3k	pi3k	PROPN
gs-4060	231	23	/	/	SYM
gs-4060	231	24	akt	akt	PROPN
gs-4060	231	25	,	,	PUNCT
gs-4060	231	26	jak	jak	PROPN
gs-4060	231	27	/	/	SYM
gs-4060	231	28	stat	stat	PROPN
gs-4060	231	29	)	)	PUNCT
gs-4060	231	30	,	,	PUNCT
gs-4060	231	31	inhibit	inhibit	NOUN
gs-4060	231	32	angiogenesis	angiogenesis	NOUN
gs-4060	231	33	,	,	PUNCT
gs-4060	231	34	modulate	modulate	VERB
gs-4060	231	35	the	the	DET
gs-4060	231	36	cell	cell	NOUN
gs-4060	231	37	cycle	cycle	NOUN
gs-4060	231	38	,	,	PUNCT
gs-4060	231	39	induce	induce	VERB
gs-4060	231	40	apoptosis	apoptosis	NOUN
gs-4060	231	41	,	,	PUNCT
gs-4060	231	42	and	and	CCONJ
gs-4060	231	43	engage	engage	VERB
gs-4060	231	44	the	the	DET
gs-4060	231	45	host	host	NOUN
gs-4060	231	46	immune	immune	ADJ
gs-4060	231	47	system	system	NOUN
gs-4060	231	48	to	to	PART
gs-4060	231	49	recognize	recognize	VERB
gs-4060	231	50	and	and	CCONJ
gs-4060	231	51	destroy	destroy	VERB
gs-4060	231	52	cancer	cancer	NOUN
gs-4060	231	53	cells	cell	NOUN
gs-4060	231	54	.	.	PUNCT
gs-4060	232	1	to	to	PART
gs-4060	232	2	analyze	analyze	VERB
gs-4060	232	3	fundamental	fundamental	ADJ
gs-4060	232	4	pharmacological	pharmacological	ADJ
gs-4060	232	5	properties	property	NOUN
gs-4060	232	6	:	:	PUNCT
gs-4060	232	7	to	to	PART
gs-4060	232	8	describe	describe	VERB
gs-4060	232	9	the	the	DET
gs-4060	232	10	key	key	ADJ
gs-4060	232	11	pharmacokinetic	pharmacokinetic	ADJ
gs-4060	232	12	and	and	CCONJ
gs-4060	232	13	pharmacodynamic	pharmacodynamic	ADJ
gs-4060	232	14	features	feature	NOUN
gs-4060	232	15	that	that	PRON
gs-4060	232	16	define	define	VERB
gs-4060	232	17	these	these	DET
gs-4060	232	18	drugs	drug	NOUN
gs-4060	232	19	,	,	PUNCT
gs-4060	232	20	including	include	VERB
gs-4060	232	21	their	their	PRON
gs-4060	232	22	absorption	absorption	NOUN
gs-4060	232	23	,	,	PUNCT
gs-4060	232	24	distribution	distribution	NOUN
gs-4060	232	25	,	,	PUNCT
gs-4060	232	26	metabolism	metabolism	NOUN
gs-4060	232	27	,	,	PUNCT
gs-4060	232	28	and	and	CCONJ
gs-4060	232	29	excretion	excretion	NOUN
gs-4060	232	30	(	(	PUNCT
gs-4060	232	31	adme	adme	NOUN
gs-4060	232	32	)	)	PUNCT
gs-4060	232	33	profiles	profile	NOUN
gs-4060	232	34	,	,	PUNCT
gs-4060	232	35	their	their	PRON
gs-4060	232	36	structure	structure	NOUN
gs-4060	232	37	-	-	PUNCT
gs-4060	232	38	activity	activity	NOUN
gs-4060	232	39	relationships	relationship	NOUN
gs-4060	232	40	(	(	PUNCT
gs-4060	232	41	sar	sar	NOUN
gs-4060	232	42	)	)	PUNCT
gs-4060	232	43	,	,	PUNCT
gs-4060	232	44	and	and	CCONJ
gs-4060	232	45	the	the	DET
gs-4060	232	46	principles	principle	NOUN
gs-4060	232	47	of	of	ADP
gs-4060	232	48	drug	drug	NOUN
gs-4060	232	49	-	-	PUNCT
gs-4060	232	50	receptor	receptor	NOUN
gs-4060	232	51	interactions	interaction	NOUN
gs-4060	232	52	that	that	PRON
gs-4060	232	53	underpin	underpin	VERB
gs-4060	232	54	their	their	PRON
gs-4060	232	55	selectivity	selectivity	NOUN
gs-4060	232	56	and	and	CCONJ
gs-4060	232	57	efficacy	efficacy	NOUN
gs-4060	232	58	.	.	PUNCT
gs-4060	233	1	to	to	PART
gs-4060	233	2	review	review	VERB
gs-4060	233	3	and	and	CCONJ
gs-4060	233	4	synthesize	synthesize	VERB
gs-4060	233	5	clinical	clinical	ADJ
gs-4060	233	6	applications	application	NOUN
gs-4060	233	7	:	:	PUNCT
gs-4060	233	8	to	to	PART
gs-4060	233	9	survey	survey	VERB
gs-4060	233	10	the	the	DET
gs-4060	233	11	established	establish	VERB
gs-4060	233	12	and	and	CCONJ
gs-4060	233	13	emerging	emerge	VERB
gs-4060	233	14	clinical	clinical	ADJ
gs-4060	233	15	uses	use	NOUN
gs-4060	233	16	of	of	ADP
gs-4060	233	17	these	these	DET
gs-4060	233	18	agents	agent	NOUN
gs-4060	233	19	across	across	ADP
gs-4060	233	20	a	a	DET
gs-4060	233	21	spectrum	spectrum	NOUN
gs-4060	233	22	of	of	ADP
gs-4060	233	23	hematological	hematological	ADJ
gs-4060	233	24	and	and	CCONJ
gs-4060	233	25	solid	solid	ADJ
gs-4060	233	26	tumor	tumor	NOUN
gs-4060	233	27	malignancies	malignancy	NOUN
gs-4060	233	28	.	.	PUNCT
gs-4060	234	1	this	this	DET
gs-4060	234	2	goal	goal	NOUN
gs-4060	234	3	emphasizes	emphasize	VERB
gs-4060	234	4	the	the	DET
gs-4060	234	5	practice	practice	NOUN
gs-4060	234	6	of	of	ADP
gs-4060	234	7	biomarker	biomarker	NOUN
gs-4060	234	8	-	-	PUNCT
gs-4060	234	9	driven	drive	VERB
gs-4060	234	10	,	,	PUNCT
gs-4060	234	11	personalized	personalized	ADJ
gs-4060	234	12	medicine	medicine	NOUN
gs-4060	234	13	,	,	PUNCT
gs-4060	234	14	detailing	detail	VERB
gs-4060	234	15	how	how	SCONJ
gs-4060	234	16	specific	specific	ADJ
gs-4060	234	17	genetic	genetic	ADJ
gs-4060	234	18	alterations	alteration	NOUN
gs-4060	234	19	or	or	CCONJ
gs-4060	234	20	protein	protein	NOUN
gs-4060	234	21	expressions	expression	NOUN
gs-4060	234	22	(	(	PUNCT
gs-4060	234	23	e.g.	e.g.	ADV
gs-4060	234	24	,	,	PUNCT
gs-4060	234	25	her2	her2	VERB
gs-4060	234	26	amplification	amplification	NOUN
gs-4060	234	27	,	,	PUNCT
gs-4060	234	28	pd	pd	PROPN
gs-4060	234	29	-	-	PUNCT
gs-4060	234	30	l1	l1	PROPN
gs-4060	234	31	status	status	NOUN
gs-4060	234	32	,	,	PUNCT
gs-4060	234	33	brca	brca	PROPN
gs-4060	234	34	mutations	mutation	NOUN
gs-4060	234	35	)	)	PUNCT
gs-4060	234	36	guide	guide	NOUN
gs-4060	234	37	drug	drug	NOUN
gs-4060	234	38	selection	selection	NOUN
gs-4060	234	39	and	and	CCONJ
gs-4060	234	40	combination	combination	NOUN
gs-4060	234	41	strategies	strategy	NOUN
gs-4060	234	42	to	to	PART
gs-4060	234	43	optimize	optimize	VERB
gs-4060	234	44	patient	patient	ADJ
gs-4060	234	45	outcomes	outcome	NOUN
gs-4060	234	46	.	.	PUNCT
gs-4060	235	1	georgian	georgian	NOUN
gs-4060	235	2	scientists/	scientists/	NUM
gs-4060	235	3	.	.	PUNCT
gs-4060	236	1	7	7	NUM
gs-4060	236	2	n	n	PRON
gs-4060	236	3	3	3	NUM
gs-4060	236	4	,	,	PUNCT
gs-4060	236	5	2025	2025	NUM
gs-4060	236	6	581	581	NUM
gs-4060	236	7	to	to	PART
gs-4060	236	8	characterize	characterize	VERB
gs-4060	236	9	unique	unique	ADJ
gs-4060	236	10	toxicity	toxicity	NOUN
gs-4060	236	11	profiles	profile	NOUN
gs-4060	236	12	:	:	PUNCT
gs-4060	237	1	to	to	PART
gs-4060	237	2	catalog	catalog	VERB
gs-4060	237	3	and	and	CCONJ
gs-4060	237	4	explain	explain	VERB
gs-4060	237	5	the	the	DET
gs-4060	237	6	distinct	distinct	ADJ
gs-4060	237	7	spectra	spectra	NOUN
gs-4060	237	8	of	of	ADP
gs-4060	237	9	adverse	adverse	ADJ
gs-4060	237	10	events	event	NOUN
gs-4060	237	11	associated	associate	VERB
gs-4060	237	12	with	with	ADP
gs-4060	237	13	different	different	ADJ
gs-4060	237	14	classes	class	NOUN
gs-4060	237	15	of	of	ADP
gs-4060	237	16	new	new	ADJ
gs-4060	237	17	anticancer	anticancer	NOUN
gs-4060	237	18	drugs	drug	NOUN
gs-4060	237	19	.	.	PUNCT
gs-4060	238	1	this	this	PRON
gs-4060	238	2	includes	include	VERB
gs-4060	238	3	a	a	DET
gs-4060	238	4	focus	focus	NOUN
gs-4060	238	5	on	on	ADP
gs-4060	238	6	"	"	PUNCT
gs-4060	238	7	ontarget	ontarget	NOUN
gs-4060	238	8	"	"	PUNCT
gs-4060	238	9	toxicities	toxicity	NOUN
gs-4060	238	10	of	of	ADP
gs-4060	238	11	targeted	target	VERB
gs-4060	238	12	agents	agent	NOUN
gs-4060	238	13	and	and	CCONJ
gs-4060	238	14	immune	immune	NOUN
gs-4060	238	15	-	-	PUNCT
gs-4060	238	16	related	relate	VERB
gs-4060	238	17	adverse	adverse	ADJ
gs-4060	238	18	events	event	NOUN
gs-4060	238	19	(	(	PUNCT
gs-4060	238	20	iraes	iraes	NOUN
gs-4060	238	21	)	)	PUNCT
gs-4060	238	22	from	from	ADP
gs-4060	238	23	immunotherapies	immunotherapy	NOUN
gs-4060	238	24	,	,	PUNCT
gs-4060	238	25	providing	provide	VERB
gs-4060	238	26	insights	insight	NOUN
gs-4060	238	27	into	into	ADP
gs-4060	238	28	their	their	PRON
gs-4060	238	29	pathophysiology	pathophysiology	NOUN
gs-4060	238	30	,	,	PUNCT
gs-4060	238	31	clinical	clinical	ADJ
gs-4060	238	32	presentation	presentation	NOUN
gs-4060	238	33	,	,	PUNCT
gs-4060	238	34	and	and	CCONJ
gs-4060	238	35	established	establish	VERB
gs-4060	238	36	guidelines	guideline	NOUN
gs-4060	238	37	for	for	ADP
gs-4060	238	38	proactive	proactive	ADJ
gs-4060	238	39	monitoring	monitoring	NOUN
gs-4060	238	40	and	and	CCONJ
gs-4060	238	41	management	management	NOUN
gs-4060	238	42	.	.	PUNCT
gs-4060	239	1	to	to	PART
gs-4060	239	2	identify	identify	VERB
gs-4060	239	3	current	current	ADJ
gs-4060	239	4	challenges	challenge	NOUN
gs-4060	239	5	and	and	CCONJ
gs-4060	239	6	future	future	ADJ
gs-4060	239	7	directions	direction	NOUN
gs-4060	239	8	:	:	PUNCT
gs-4060	239	9	to	to	PART
gs-4060	239	10	critically	critically	ADV
gs-4060	239	11	appraise	appraise	VERB
gs-4060	239	12	the	the	DET
gs-4060	239	13	limitations	limitation	NOUN
gs-4060	239	14	of	of	ADP
gs-4060	239	15	current	current	ADJ
gs-4060	239	16	therapies	therapy	NOUN
gs-4060	239	17	,	,	PUNCT
gs-4060	239	18	including	include	VERB
gs-4060	239	19	the	the	DET
gs-4060	239	20	pervasive	pervasive	ADJ
gs-4060	239	21	problems	problem	NOUN
gs-4060	239	22	of	of	ADP
gs-4060	239	23	innate	innate	ADJ
gs-4060	239	24	and	and	CCONJ
gs-4060	239	25	acquired	acquire	VERB
gs-4060	239	26	resistance	resistance	NOUN
gs-4060	239	27	,	,	PUNCT
gs-4060	239	28	tumor	tumor	NOUN
gs-4060	239	29	heterogeneity	heterogeneity	NOUN
gs-4060	239	30	,	,	PUNCT
gs-4060	239	31	and	and	CCONJ
gs-4060	239	32	high	high	ADJ
gs-4060	239	33	financial	financial	ADJ
gs-4060	239	34	toxicity	toxicity	NOUN
gs-4060	239	35	.	.	PUNCT
gs-4060	240	1	furthermore	furthermore	ADV
gs-4060	240	2	,	,	PUNCT
gs-4060	240	3	this	this	DET
gs-4060	240	4	review	review	NOUN
gs-4060	240	5	aims	aim	VERB
gs-4060	240	6	to	to	PART
gs-4060	240	7	highlight	highlight	VERB
gs-4060	240	8	promising	promising	ADJ
gs-4060	240	9	avenues	avenue	NOUN
gs-4060	240	10	of	of	ADP
gs-4060	240	11	ongoing	ongoing	ADJ
gs-4060	240	12	research	research	NOUN
gs-4060	240	13	,	,	PUNCT
gs-4060	240	14	such	such	ADJ
gs-4060	240	15	as	as	ADP
gs-4060	240	16	the	the	DET
gs-4060	240	17	development	development	NOUN
gs-4060	240	18	of	of	ADP
gs-4060	240	19	novel	novel	ADJ
gs-4060	240	20	targets	target	NOUN
gs-4060	240	21	(	(	PUNCT
gs-4060	240	22	e.g.	e.g.	ADV
gs-4060	240	23	,	,	PUNCT
gs-4060	240	24	kras	kras	PROPN
gs-4060	240	25	g12c	g12c	NUM
gs-4060	240	26	)	)	PUNCT
gs-4060	240	27	,	,	PUNCT
gs-4060	240	28	next	next	ADJ
gs-4060	240	29	-	-	PUNCT
gs-4060	240	30	generation	generation	NOUN
gs-4060	240	31	immunotherapies	immunotherapy	NOUN
gs-4060	240	32	,	,	PUNCT
gs-4060	240	33	bispecific	bispecific	NOUN
gs-4060	240	34	antibodies	antibodie	VERB
gs-4060	240	35	,	,	PUNCT
gs-4060	240	36	and	and	CCONJ
gs-4060	240	37	strategies	strategy	NOUN
gs-4060	240	38	to	to	PART
gs-4060	240	39	overcome	overcome	VERB
gs-4060	240	40	the	the	DET
gs-4060	240	41	immunosuppressive	immunosuppressive	ADJ
gs-4060	240	42	tumor	tumor	NOUN
gs-4060	240	43	microenvironment	microenvironment	NOUN
gs-4060	240	44	.	.	PUNCT
gs-4060	241	1	by	by	ADP
gs-4060	241	2	fulfilling	fulfil	VERB
gs-4060	241	3	these	these	DET
gs-4060	241	4	goals	goal	NOUN
gs-4060	241	5	,	,	PUNCT
gs-4060	241	6	this	this	DET
gs-4060	241	7	review	review	NOUN
gs-4060	241	8	endeavors	endeavor	VERB
gs-4060	241	9	to	to	PART
gs-4060	241	10	serve	serve	VERB
gs-4060	241	11	as	as	ADP
gs-4060	241	12	a	a	DET
gs-4060	241	13	valuable	valuable	ADJ
gs-4060	241	14	educational	educational	ADJ
gs-4060	241	15	and	and	CCONJ
gs-4060	241	16	reference	reference	NOUN
gs-4060	241	17	resource	resource	NOUN
gs-4060	241	18	for	for	ADP
gs-4060	241	19	oncologists	oncologist	NOUN
gs-4060	241	20	,	,	PUNCT
gs-4060	241	21	clinical	clinical	ADJ
gs-4060	241	22	pharmacists	pharmacist	NOUN
gs-4060	241	23	,	,	PUNCT
gs-4060	241	24	researchers	researcher	NOUN
gs-4060	241	25	,	,	PUNCT
gs-4060	241	26	and	and	CCONJ
gs-4060	241	27	students	student	NOUN
gs-4060	241	28	,	,	PUNCT
gs-4060	241	29	facilitating	facilitate	VERB
gs-4060	241	30	a	a	DET
gs-4060	241	31	deeper	deep	ADJ
gs-4060	241	32	understanding	understanding	NOUN
gs-4060	241	33	of	of	ADP
gs-4060	241	34	the	the	DET
gs-4060	241	35	scientific	scientific	ADJ
gs-4060	241	36	principles	principle	NOUN
gs-4060	241	37	that	that	PRON
gs-4060	241	38	govern	govern	VERB
gs-4060	241	39	the	the	DET
gs-4060	241	40	use	use	NOUN
gs-4060	241	41	of	of	ADP
gs-4060	241	42	modern	modern	ADJ
gs-4060	241	43	anticancer	anticancer	NOUN
gs-4060	241	44	drugs	drug	NOUN
gs-4060	241	45	and	and	CCONJ
gs-4060	241	46	ultimately	ultimately	ADV
gs-4060	241	47	contributing	contribute	VERB
gs-4060	241	48	to	to	ADP
gs-4060	241	49	improved	improve	VERB
gs-4060	241	50	patient	patient	ADJ
gs-4060	241	51	care	care	NOUN
gs-4060	241	52	.	.	PUNCT
gs-4060	242	1	results	result	NOUN
gs-4060	242	2	and	and	CCONJ
gs-4060	242	3	discussion	discussion	VERB
gs-4060	242	4	the	the	DET
gs-4060	242	5	systematic	systematic	ADJ
gs-4060	242	6	review	review	NOUN
gs-4060	242	7	of	of	ADP
gs-4060	242	8	the	the	DET
gs-4060	242	9	contemporary	contemporary	PROPN
gs-4060	242	10	literature	literature	PROPN
gs-4060	242	11	reveals	reveal	VERB
gs-4060	242	12	a	a	DET
gs-4060	242	13	profoundly	profoundly	ADV
gs-4060	242	14	transformed	transform	VERB
gs-4060	242	15	oncological	oncological	ADJ
gs-4060	242	16	therapeutic	therapeutic	ADJ
gs-4060	242	17	landscape	landscape	NOUN
gs-4060	242	18	,	,	PUNCT
gs-4060	242	19	defined	define	VERB
gs-4060	242	20	by	by	ADP
gs-4060	242	21	a	a	DET
gs-4060	242	22	departure	departure	NOUN
gs-4060	242	23	from	from	ADP
gs-4060	242	24	broadly	broadly	ADV
gs-4060	242	25	cytotoxic	cytotoxic	ADJ
gs-4060	242	26	strategies	strategy	NOUN
gs-4060	242	27	towards	towards	ADP
gs-4060	242	28	an	an	DET
gs-4060	242	29	era	era	NOUN
gs-4060	242	30	of	of	ADP
gs-4060	242	31	precision	precision	NOUN
gs-4060	242	32	medicine	medicine	NOUN
gs-4060	242	33	.	.	PUNCT
gs-4060	243	1	this	this	DET
gs-4060	243	2	paradigm	paradigm	NOUN
gs-4060	243	3	shift	shift	NOUN
gs-4060	243	4	is	be	AUX
gs-4060	243	5	underpinned	underpin	VERB
gs-4060	243	6	by	by	ADP
gs-4060	243	7	a	a	DET
gs-4060	243	8	sophisticated	sophisticated	ADJ
gs-4060	243	9	understanding	understanding	NOUN
gs-4060	243	10	of	of	ADP
gs-4060	243	11	cancer	cancer	NOUN
gs-4060	243	12	biology	biology	NOUN
gs-4060	243	13	,	,	PUNCT
gs-4060	243	14	which	which	PRON
gs-4060	243	15	has	have	AUX
gs-4060	243	16	enabled	enable	VERB
gs-4060	243	17	the	the	DET
gs-4060	243	18	development	development	NOUN
gs-4060	243	19	of	of	ADP
gs-4060	243	20	drugs	drug	NOUN
gs-4060	243	21	designed	design	VERB
gs-4060	243	22	with	with	ADP
gs-4060	243	23	exquisite	exquisite	ADJ
gs-4060	243	24	specificity	specificity	NOUN
gs-4060	243	25	for	for	ADP
gs-4060	243	26	molecular	molecular	ADJ
gs-4060	243	27	targets	target	NOUN
gs-4060	243	28	.	.	PUNCT
gs-4060	244	1	the	the	DET
gs-4060	244	2	results	result	NOUN
gs-4060	244	3	of	of	ADP
gs-4060	244	4	this	this	DET
gs-4060	244	5	analysis	analysis	NOUN
gs-4060	244	6	are	be	AUX
gs-4060	244	7	organized	organize	VERB
gs-4060	244	8	to	to	PART
gs-4060	244	9	reflect	reflect	VERB
gs-4060	244	10	the	the	DET
gs-4060	244	11	interconnected	interconnected	ADJ
gs-4060	244	12	nature	nature	NOUN
gs-4060	244	13	of	of	ADP
gs-4060	244	14	drug	drug	NOUN
gs-4060	244	15	classification	classification	NOUN
gs-4060	244	16	,	,	PUNCT
gs-4060	244	17	mechanism	mechanism	NOUN
gs-4060	244	18	,	,	PUNCT
gs-4060	244	19	pharmacology	pharmacology	NOUN
gs-4060	244	20	,	,	PUNCT
gs-4060	244	21	clinical	clinical	ADJ
gs-4060	244	22	application	application	NOUN
gs-4060	244	23	,	,	PUNCT
gs-4060	244	24	and	and	CCONJ
gs-4060	244	25	toxicological	toxicological	ADJ
gs-4060	244	26	profile	profile	NOUN
gs-4060	244	27	,	,	PUNCT
gs-4060	244	28	demonstrating	demonstrate	VERB
gs-4060	244	29	that	that	SCONJ
gs-4060	244	30	these	these	DET
gs-4060	244	31	aspects	aspect	NOUN
gs-4060	244	32	are	be	AUX
gs-4060	244	33	not	not	PART
gs-4060	244	34	discrete	discrete	ADJ
gs-4060	244	35	but	but	CCONJ
gs-4060	244	36	rather	rather	ADV
gs-4060	244	37	form	form	VERB
gs-4060	244	38	a	a	DET
gs-4060	244	39	cohesive	cohesive	ADJ
gs-4060	244	40	scientific	scientific	ADJ
gs-4060	244	41	narrative	narrative	NOUN
gs-4060	244	42	.	.	PUNCT
gs-4060	245	1	recent	recent	ADJ
gs-4060	245	2	fda	fda	PROPN
gs-4060	245	3	approvals	approval	NOUN
gs-4060	245	4	in	in	ADP
gs-4060	245	5	oncology	oncology	NOUN
gs-4060	245	6	(	(	PUNCT
gs-4060	245	7	2024	2024	NUM
gs-4060	245	8	-	-	SYM
gs-4060	245	9	2025	2025	NUM
gs-4060	245	10	)	)	PUNCT
gs-4060	245	11	in	in	ADP
gs-4060	245	12	2024	2024	NUM
gs-4060	245	13	,	,	PUNCT
gs-4060	245	14	the	the	DET
gs-4060	245	15	u.s	u.s	PROPN
gs-4060	245	16	.	.	PROPN
gs-4060	245	17	food	food	PROPN
gs-4060	245	18	and	and	CCONJ
gs-4060	245	19	drug	drug	PROPN
gs-4060	245	20	administration	administration	PROPN
gs-4060	245	21	(	(	PUNCT
gs-4060	245	22	fda	fda	PROPN
gs-4060	245	23	)	)	PUNCT
gs-4060	245	24	approved	approve	VERB
gs-4060	245	25	50	50	NUM
gs-4060	245	26	novel	novel	ADJ
gs-4060	245	27	drugs	drug	NOUN
gs-4060	245	28	,	,	PUNCT
gs-4060	245	29	with	with	ADP
gs-4060	245	30	15	15	NUM
gs-4060	245	31	specifically	specifically	ADV
gs-4060	245	32	targeting	target	VERB
gs-4060	245	33	cancer	cancer	NOUN
gs-4060	245	34	treatment	treatment	NOUN
gs-4060	245	35	or	or	CCONJ
gs-4060	245	36	supportive	supportive	ADJ
gs-4060	245	37	care	care	NOUN
gs-4060	245	38	,	,	PUNCT
gs-4060	245	39	reflecting	reflect	VERB
gs-4060	245	40	a	a	DET
gs-4060	245	41	robust	robust	ADJ
gs-4060	245	42	year	year	NOUN
gs-4060	245	43	for	for	ADP
gs-4060	245	44	oncology	oncology	NOUN
gs-4060	245	45	innovations	innovation	NOUN
gs-4060	245	46	.	.	PUNCT
gs-4060	246	1	by	by	ADP
gs-4060	246	2	mid-2025	mid-2025	NOUN
gs-4060	246	3	,	,	PUNCT
gs-4060	246	4	additional	additional	ADJ
gs-4060	246	5	approvals	approval	NOUN
gs-4060	246	6	have	have	AUX
gs-4060	246	7	further	far	ADV
gs-4060	246	8	expanded	expand	VERB
gs-4060	246	9	therapeutic	therapeutic	ADJ
gs-4060	246	10	options	option	NOUN
gs-4060	246	11	.	.	PUNCT
gs-4060	247	1	on	on	ADP
gs-4060	247	2	june	june	PROPN
gs-4060	247	3	18	18	NUM
gs-4060	247	4	,	,	PUNCT
gs-4060	247	5	2025	2025	NUM
gs-4060	247	6	,	,	PUNCT
gs-4060	247	7	tafasitamab	tafasitamab	NOUN
gs-4060	247	8	-	-	PUNCT
gs-4060	247	9	cxix	cxix	ADJ
gs-4060	247	10	(	(	PUNCT
gs-4060	247	11	monjuvi	monjuvi	NOUN
gs-4060	247	12	)	)	PUNCT
gs-4060	247	13	was	be	AUX
gs-4060	247	14	approved	approve	VERB
gs-4060	247	15	in	in	ADP
gs-4060	247	16	combination	combination	NOUN
gs-4060	247	17	with	with	ADP
gs-4060	247	18	lenalidomide	lenalidomide	NOUN
gs-4060	247	19	and	and	CCONJ
gs-4060	247	20	rituximab	rituximab	NOUN
gs-4060	247	21	for	for	SCONJ
gs-4060	247	22	adults	adult	NOUN
gs-4060	247	23	with	with	ADP
gs-4060	247	24	relapsed	relapse	VERB
gs-4060	247	25	or	or	CCONJ
gs-4060	247	26	refractory	refractory	NOUN
gs-4060	247	27	diffuse	diffuse	VERB
gs-4060	247	28	large	large	ADJ
gs-4060	247	29	b	b	NUM
gs-4060	247	30	-	-	PUNCT
gs-4060	247	31	cell	cell	NOUN
gs-4060	247	32	lymphoma	lymphoma	NOUN
gs-4060	247	33	(	(	PUNCT
gs-4060	247	34	dlbcl	dlbcl	NOUN
gs-4060	247	35	)	)	PUNCT
gs-4060	247	36	and	and	CCONJ
gs-4060	247	37	other	other	ADJ
gs-4060	247	38	lymphomas	lymphoma	NOUN
gs-4060	247	39	.	.	PUNCT
gs-4060	248	1	in	in	ADP
gs-4060	248	2	the	the	DET
gs-4060	248	3	second	second	ADJ
gs-4060	248	4	quarter	quarter	NOUN
gs-4060	248	5	of	of	ADP
gs-4060	248	6	2025	2025	NUM
gs-4060	248	7	,	,	PUNCT
gs-4060	248	8	13	13	NUM
gs-4060	248	9	new	new	ADJ
gs-4060	248	10	oncology	oncology	NOUN
gs-4060	248	11	approvals	approval	NOUN
gs-4060	248	12	were	be	AUX
gs-4060	248	13	granted	grant	VERB
gs-4060	248	14	,	,	PUNCT
gs-4060	248	15	addressing	address	VERB
gs-4060	248	16	rare	rare	ADJ
gs-4060	248	17	cancers	cancer	NOUN
gs-4060	248	18	,	,	PUNCT
gs-4060	248	19	head	head	NOUN
gs-4060	248	20	and	and	CCONJ
gs-4060	248	21	neck	neck	VERB
gs-4060	248	22	squamous	squamous	ADJ
gs-4060	248	23	cell	cell	NOUN
gs-4060	248	24	carcinoma	carcinoma	NOUN
gs-4060	248	25	,	,	PUNCT
gs-4060	248	26	and	and	CCONJ
gs-4060	248	27	supportive	supportive	ADJ
gs-4060	248	28	care	care	NOUN
gs-4060	248	29	needs	need	NOUN
gs-4060	248	30	.	.	PUNCT
gs-4060	249	1	notable	notable	ADJ
gs-4060	249	2	approvals	approval	NOUN
gs-4060	249	3	include	include	VERB
gs-4060	249	4	vimseltinib	vimseltinib	NOUN
gs-4060	249	5	(	(	PUNCT
gs-4060	249	6	romvimza	romvimza	NOUN
gs-4060	249	7	)	)	PUNCT
gs-4060	249	8	for	for	ADP
gs-4060	249	9	tenosynovial	tenosynovial	ADJ
gs-4060	249	10	giant	giant	ADJ
gs-4060	249	11	cell	cell	NOUN
gs-4060	249	12	tumor	tumor	NOUN
gs-4060	249	13	,	,	PUNCT
gs-4060	249	14	mirdametinib	mirdametinib	ADJ
gs-4060	249	15	(	(	PUNCT
gs-4060	249	16	gomekli	gomekli	NOUN
gs-4060	249	17	)	)	PUNCT
gs-4060	249	18	for	for	ADP
gs-4060	249	19	neurofibromatosis	neurofibromatosis	NOUN
gs-4060	249	20	type	type	NOUN
gs-4060	249	21	1	1	NUM
gs-4060	249	22	with	with	ADP
gs-4060	249	23	symptomatic	symptomatic	ADJ
gs-4060	249	24	plexiform	plexiform	NOUN
gs-4060	249	25	neurofibromas	neurofibroma	NOUN
gs-4060	249	26	,	,	PUNCT
gs-4060	249	27	and	and	CCONJ
gs-4060	249	28	suzetrigine	suzetrigine	NOUN
gs-4060	249	29	(	(	PUNCT
gs-4060	249	30	journavx	journavx	NOUN
gs-4060	249	31	)	)	PUNCT
gs-4060	249	32	for	for	ADP
gs-4060	249	33	pain	pain	NOUN
gs-4060	249	34	management	management	NOUN
gs-4060	249	35	in	in	ADP
gs-4060	249	36	cancer	cancer	NOUN
gs-4060	249	37	patients	patient	NOUN
gs-4060	249	38	.	.	PUNCT
gs-4060	250	1	encorafenib	encorafenib	NOUN
gs-4060	250	2	combined	combine	VERB
gs-4060	250	3	with	with	ADP
gs-4060	250	4	cetuximab	cetuximab	NOUN
gs-4060	250	5	and	and	CCONJ
gs-4060	250	6	mfolfox6	mfolfox6	NOUN
gs-4060	250	7	was	be	AUX
gs-4060	250	8	approved	approve	VERB
gs-4060	250	9	for	for	ADP
gs-4060	250	10	first	first	ADJ
gs-4060	250	11	-	-	PUNCT
gs-4060	250	12	line	line	NOUN
gs-4060	250	13	treatment	treatment	NOUN
gs-4060	250	14	of	of	ADP
gs-4060	250	15	braf	braf	NOUN
gs-4060	250	16	v600e	v600e	NOUN
gs-4060	250	17	-	-	PUNCT
gs-4060	250	18	mutated	mutate	VERB
gs-4060	250	19	metastatic	metastatic	ADJ
gs-4060	250	20	colorectal	colorectal	ADJ
gs-4060	250	21	cance	cance	NOUN
gs-4060	250	22	.	.	PUNCT
gs-4060	251	1	in	in	ADP
gs-4060	251	2	january	january	PROPN
gs-4060	251	3	2025	2025	NUM
gs-4060	251	4	,	,	PUNCT
gs-4060	251	5	approvals	approval	NOUN
gs-4060	251	6	included	include	VERB
gs-4060	251	7	fam	fam	NOUN
gs-4060	251	8	-	-	PUNCT
gs-4060	251	9	trastuzumab	trastuzumab	NOUN
gs-4060	251	10	deruxtecan	deruxtecan	ADJ
gs-4060	251	11	-	-	PUNCT
gs-4060	251	12	nxki	nxki	NOUN
gs-4060	251	13	for	for	ADP
gs-4060	251	14	her2	her2	NOUN
gs-4060	251	15	-	-	PUNCT
gs-4060	251	16	positive	positive	ADJ
gs-4060	251	17	solid	solid	ADJ
gs-4060	251	18	tumors	tumor	NOUN
gs-4060	251	19	,	,	PUNCT
gs-4060	251	20	acalabrutinib	acalabrutinib	NOUN
gs-4060	251	21	for	for	ADP
gs-4060	251	22	mantle	mantle	ADJ
gs-4060	251	23	cell	cell	NOUN
gs-4060	251	24	lymphoma	lymphoma	NOUN
gs-4060	251	25	,	,	PUNCT
gs-4060	251	26	datopotamab	datopotamab	NOUN
gs-4060	251	27	deruxtecan	deruxtecan	NOUN
gs-4060	251	28	for	for	ADP
gs-4060	251	29	trop2	trop2	NOUN
gs-4060	251	30	-	-	PUNCT
gs-4060	251	31	positive	positive	ADJ
gs-4060	251	32	non	non	ADJ
gs-4060	251	33	-	-	ADJ
gs-4060	251	34	small	small	ADJ
gs-4060	251	35	cell	cell	NOUN
gs-4060	251	36	lung	lung	NOUN
gs-4060	251	37	cancer	cancer	NOUN
gs-4060	251	38	(	(	PUNCT
gs-4060	251	39	nsclc	nsclc	NOUN
gs-4060	251	40	)	)	PUNCT
gs-4060	251	41	,	,	PUNCT
gs-4060	251	42	and	and	CCONJ
gs-4060	251	43	treosulfan	treosulfan	NOUN
gs-4060	251	44	for	for	ADP
gs-4060	251	45	conditioning	condition	VERB
gs-4060	251	46	regimens	regimen	NOUN
gs-4060	251	47	in	in	ADP
gs-4060	251	48	stem	stem	NOUN
gs-4060	251	49	cell	cell	NOUN
gs-4060	251	50	transplants	transplant	NOUN
gs-4060	251	51	.	.	PUNCT
gs-4060	252	1	georgian	georgian	NOUN
gs-4060	252	2	scientists/	scientists/	NUM
gs-4060	252	3	.	.	PUNCT
gs-4060	253	1	7	7	NUM
gs-4060	253	2	n	n	PRON
gs-4060	253	3	3	3	NUM
gs-4060	253	4	,	,	PUNCT
gs-4060	253	5	2025	2025	NUM
gs-4060	253	6	582	582	NUM
gs-4060	253	7	biologics	biologic	NOUN
gs-4060	253	8	and	and	CCONJ
gs-4060	253	9	biosimilars	biosimilar	NOUN
gs-4060	253	10	dominated	dominate	VERB
gs-4060	253	11	early	early	ADJ
gs-4060	253	12	2025	2025	NUM
gs-4060	253	13	approvals	approval	NOUN
gs-4060	253	14	,	,	PUNCT
gs-4060	253	15	with	with	ADP
gs-4060	253	16	pembrolizumab	pembrolizumab	NOUN
gs-4060	253	17	expanded	expand	VERB
gs-4060	253	18	for	for	ADP
gs-4060	253	19	gastric	gastric	ADJ
gs-4060	253	20	and	and	CCONJ
gs-4060	253	21	gastroesophageal	gastroesophageal	VERB
gs-4060	253	22	junction	junction	NOUN
gs-4060	253	23	(	(	PUNCT
gs-4060	253	24	gej	gej	NOUN
gs-4060	253	25	)	)	PUNCT
gs-4060	253	26	adenocarcinoma	adenocarcinoma	NOUN
gs-4060	253	27	.	.	PUNCT
gs-4060	254	1	research	research	NOUN
gs-4060	254	2	from	from	ADP
gs-4060	254	3	memorial	memorial	ADJ
gs-4060	254	4	sloan	sloan	PROPN
gs-4060	254	5	kettering	kettering	PROPN
gs-4060	254	6	cancer	cancer	PROPN
gs-4060	254	7	center	center	PROPN
gs-4060	254	8	contributed	contribute	VERB
gs-4060	254	9	to	to	ADP
gs-4060	254	10	11	11	NUM
gs-4060	254	11	approvals	approval	NOUN
gs-4060	254	12	in	in	ADP
gs-4060	254	13	2024	2024	NUM
gs-4060	254	14	,	,	PUNCT
gs-4060	254	15	underscoring	underscore	VERB
gs-4060	254	16	academic	academic	ADJ
gs-4060	254	17	-	-	PUNCT
gs-4060	254	18	industry	industry	NOUN
gs-4060	254	19	collaboration	collaboration	NOUN
gs-4060	254	20	.	.	PUNCT
gs-4060	255	1	small	small	ADJ
gs-4060	255	2	-	-	PUNCT
gs-4060	255	3	molecule	molecule	NOUN
gs-4060	255	4	drugs	drug	NOUN
gs-4060	255	5	like	like	ADP
gs-4060	255	6	aprocitentan	aprocitentan	NOUN
gs-4060	255	7	(	(	PUNCT
gs-4060	255	8	tryvio	tryvio	NOUN
gs-4060	255	9	)	)	PUNCT
gs-4060	255	10	,	,	PUNCT
gs-4060	255	11	though	though	SCONJ
gs-4060	255	12	not	not	PART
gs-4060	255	13	exclusively	exclusively	ADV
gs-4060	255	14	for	for	ADP
gs-4060	255	15	cancer	cancer	NOUN
gs-4060	255	16	,	,	PUNCT
gs-4060	255	17	highlight	highlight	VERB
gs-4060	255	18	the	the	DET
gs-4060	255	19	diversity	diversity	NOUN
gs-4060	255	20	of	of	ADP
gs-4060	255	21	therapeutic	therapeutic	ADJ
gs-4060	255	22	advancements	advancement	NOUN
gs-4060	255	23	.	.	PUNCT
gs-4060	256	1	fast	fast	ADV
gs-4060	256	2	-	-	PUNCT
gs-4060	256	3	tracked	track	VERB
gs-4060	256	4	drugs	drug	NOUN
gs-4060	256	5	in	in	ADP
gs-4060	256	6	may	may	PROPN
gs-4060	256	7	2025	2025	NUM
gs-4060	256	8	included	include	VERB
gs-4060	256	9	isb	isb	PROPN
gs-4060	256	10	2001	2001	NUM
gs-4060	256	11	for	for	ADP
gs-4060	256	12	multiple	multiple	ADJ
gs-4060	256	13	myeloma	myeloma	NOUN
gs-4060	256	14	and	and	CCONJ
gs-4060	256	15	adrx-0706	adrx-0706	NOUN
gs-4060	256	16	for	for	ADP
gs-4060	256	17	cervical	cervical	ADJ
gs-4060	256	18	cancer	cancer	NOUN
gs-4060	256	19	,	,	PUNCT
gs-4060	256	20	reflecting	reflect	VERB
gs-4060	256	21	accelerated	accelerate	VERB
gs-4060	256	22	pathways	pathway	NOUN
gs-4060	256	23	for	for	ADP
gs-4060	256	24	unmet	unmet	NOUN
gs-4060	256	25	needs	need	NOUN
gs-4060	256	26	.	.	PUNCT
gs-4060	257	1	in	in	ADP
gs-4060	257	2	2024	2024	NUM
gs-4060	257	3	,	,	PUNCT
gs-4060	257	4	32	32	NUM
gs-4060	257	5	new	new	ADJ
gs-4060	257	6	chemical	chemical	NOUN
gs-4060	257	7	entities	entity	NOUN
gs-4060	257	8	and	and	CCONJ
gs-4060	257	9	18	18	NUM
gs-4060	257	10	biologics	biologic	NOUN
gs-4060	257	11	were	be	AUX
gs-4060	257	12	approved	approve	VERB
gs-4060	257	13	,	,	PUNCT
gs-4060	257	14	with	with	ADP
gs-4060	257	15	oncology	oncology	NOUN
gs-4060	257	16	leading	lead	VERB
gs-4060	257	17	therapeutic	therapeutic	ADJ
gs-4060	257	18	categories	category	NOUN
gs-4060	257	19	.	.	PUNCT
gs-4060	258	1	first	first	ADJ
gs-4060	258	2	-	-	PUNCT
gs-4060	258	3	in	in	ADP
gs-4060	258	4	-	-	PUNCT
gs-4060	258	5	class	class	NOUN
gs-4060	258	6	drugs	drug	NOUN
gs-4060	258	7	projected	project	VERB
gs-4060	258	8	for	for	ADP
gs-4060	258	9	2025	2025	NUM
gs-4060	258	10	include	include	VERB
gs-4060	258	11	donidalorsen	donidalorsen	NOUN
gs-4060	258	12	,	,	PUNCT
gs-4060	258	13	fitusiran	fitusiran	NOUN
gs-4060	258	14	,	,	PUNCT
gs-4060	258	15	ivonescimab	ivonescimab	NOUN
gs-4060	258	16	,	,	PUNCT
gs-4060	258	17	and	and	CCONJ
gs-4060	258	18	others	other	NOUN
gs-4060	258	19	,	,	PUNCT
gs-4060	258	20	promising	promise	VERB
gs-4060	258	21	further	further	ADJ
gs-4060	258	22	innovation	innovation	NOUN
gs-4060	258	23	.	.	PUNCT
gs-4060	259	1	alectinib	alectinib	NOUN
gs-4060	259	2	’s	’s	PART
gs-4060	259	3	approval	approval	NOUN
gs-4060	259	4	for	for	ADP
gs-4060	259	5	alkpositive	alkpositive	ADJ
gs-4060	259	6	nsclc	nsclc	NOUN
gs-4060	259	7	in	in	ADP
gs-4060	259	8	q2	q2	PROPN
gs-4060	259	9	2024	2024	NUM
gs-4060	259	10	exemplifies	exemplify	VERB
gs-4060	259	11	continued	continued	ADJ
gs-4060	259	12	progress	progress	NOUN
gs-4060	259	13	in	in	ADP
gs-4060	259	14	targeted	target	VERB
gs-4060	259	15	therapies	therapy	NOUN
gs-4060	259	16	.	.	PUNCT
gs-4060	260	1	mechanisms	mechanism	NOUN
gs-4060	260	2	of	of	ADP
gs-4060	260	3	action	action	NOUN
gs-4060	260	4	new	new	ADJ
gs-4060	260	5	anticancer	anticancer	NOUN
gs-4060	260	6	drugs	drug	NOUN
gs-4060	260	7	target	target	VERB
gs-4060	260	8	cancer	cancer	NOUN
gs-4060	260	9	hallmarks	hallmark	NOUN
gs-4060	260	10	through	through	ADP
gs-4060	260	11	diverse	diverse	ADJ
gs-4060	260	12	mechanisms	mechanism	NOUN
gs-4060	260	13	.	.	PUNCT
gs-4060	261	1	antibody	antibody	NOUN
gs-4060	261	2	-	-	PUNCT
gs-4060	261	3	drug	drug	NOUN
gs-4060	261	4	conjugates	conjugate	NOUN
gs-4060	261	5	(	(	PUNCT
gs-4060	261	6	adcs	adcs	ADJ
gs-4060	261	7	)	)	PUNCT
gs-4060	261	8	like	like	ADP
gs-4060	261	9	fam	fam	NOUN
gs-4060	261	10	-	-	PUNCT
gs-4060	261	11	trastuzumab	trastuzumab	NOUN
gs-4060	261	12	deruxtecan	deruxtecan	ADJ
gs-4060	261	13	-	-	PUNCT
gs-4060	261	14	nxki	nxki	NOUN
gs-4060	261	15	deliver	deliver	VERB
gs-4060	261	16	cytotoxic	cytotoxic	ADJ
gs-4060	261	17	payloads	payload	NOUN
gs-4060	261	18	(	(	PUNCT
gs-4060	261	19	e.g.	e.g.	ADV
gs-4060	261	20	,	,	PUNCT
gs-4060	261	21	topoisomerase	topoisomerase	VERB
gs-4060	261	22	i	i	PRON
gs-4060	261	23	inhibitors	inhibitor	NOUN
gs-4060	261	24	)	)	PUNCT
gs-4060	261	25	to	to	PART
gs-4060	261	26	her2	her2	VERB
gs-4060	261	27	-	-	PUNCT
gs-4060	261	28	expressing	express	VERB
gs-4060	261	29	cells	cell	NOUN
gs-4060	261	30	,	,	PUNCT
gs-4060	261	31	inducing	induce	VERB
gs-4060	261	32	dna	dna	ADJ
gs-4060	261	33	damage	damage	NOUN
gs-4060	261	34	and	and	CCONJ
gs-4060	261	35	apoptosis	apoptosis	NOUN
gs-4060	261	36	.	.	PUNCT
gs-4060	262	1	tyrosine	tyrosine	PROPN
gs-4060	262	2	kinase	kinase	PROPN
gs-4060	262	3	inhibitors	inhibitor	NOUN
gs-4060	262	4	(	(	PUNCT
gs-4060	262	5	tkis	tkis	NOUN
gs-4060	262	6	)	)	PUNCT
gs-4060	262	7	such	such	ADJ
gs-4060	262	8	as	as	ADP
gs-4060	262	9	vimseltinib	vimseltinib	NOUN
gs-4060	262	10	inhibit	inhibit	VERB
gs-4060	262	11	colony	colony	NOUN
gs-4060	262	12	-	-	PUNCT
gs-4060	262	13	stimulating	stimulate	VERB
gs-4060	262	14	factor	factor	NOUN
gs-4060	262	15	1	1	NUM
gs-4060	262	16	receptor	receptor	NOUN
gs-4060	262	17	(	(	PUNCT
gs-4060	262	18	csf1r	csf1r	NOUN
gs-4060	262	19	)	)	PUNCT
gs-4060	262	20	,	,	PUNCT
gs-4060	262	21	disrupting	disrupt	VERB
gs-4060	262	22	tumor	tumor	NOUN
gs-4060	262	23	-	-	PUNCT
gs-4060	262	24	associated	associate	VERB
gs-4060	262	25	macrophages	macrophage	NOUN
gs-4060	262	26	in	in	ADP
gs-4060	262	27	tenosynovial	tenosynovial	ADJ
gs-4060	262	28	giant	giant	ADJ
gs-4060	262	29	cell	cell	NOUN
gs-4060	262	30	tumors	tumor	NOUN
gs-4060	262	31	.	.	PUNCT
gs-4060	263	1	immune	immune	ADJ
gs-4060	263	2	checkpoint	checkpoint	NOUN
gs-4060	263	3	inhibitors	inhibitor	NOUN
gs-4060	263	4	,	,	PUNCT
gs-4060	263	5	like	like	ADP
gs-4060	263	6	pembrolizumab	pembrolizumab	NOUN
gs-4060	263	7	,	,	PUNCT
gs-4060	263	8	block	block	NOUN
gs-4060	263	9	pd-1	pd-1	ADP
gs-4060	263	10	/	/	SYM
gs-4060	263	11	pd	pd	ADJ
gs-4060	263	12	-	-	PUNCT
gs-4060	263	13	l1	l1	PROPN
gs-4060	263	14	interactions	interaction	NOUN
gs-4060	263	15	,	,	PUNCT
gs-4060	263	16	enhancing	enhance	VERB
gs-4060	263	17	t	t	NOUN
gs-4060	263	18	-	-	PUNCT
gs-4060	263	19	cell	cell	NOUN
gs-4060	263	20	activity	activity	NOUN
gs-4060	263	21	against	against	ADP
gs-4060	263	22	tumors	tumor	NOUN
gs-4060	263	23	such	such	ADJ
gs-4060	263	24	as	as	ADP
gs-4060	263	25	gastric	gastric	ADJ
gs-4060	263	26	cancers	cancer	NOUN
gs-4060	263	27	.	.	PUNCT
gs-4060	264	1	bispecific	bispecific	NOUN
gs-4060	264	2	antibodies	antibodie	VERB
gs-4060	264	3	,	,	PUNCT
gs-4060	264	4	such	such	ADJ
gs-4060	264	5	as	as	ADP
gs-4060	264	6	tafasitamab	tafasitamab	NOUN
gs-4060	264	7	,	,	PUNCT
gs-4060	264	8	engage	engage	VERB
gs-4060	264	9	cd19	cd19	PROPN
gs-4060	264	10	on	on	ADP
gs-4060	264	11	b	b	NOUN
gs-4060	264	12	-	-	PUNCT
gs-4060	264	13	cells	cell	NOUN
gs-4060	264	14	and	and	CCONJ
gs-4060	264	15	cd3	cd3	VERB
gs-4060	264	16	on	on	ADP
gs-4060	264	17	t	t	PROPN
gs-4060	264	18	-	-	PUNCT
gs-4060	264	19	cells	cell	NOUN
gs-4060	264	20	,	,	PUNCT
gs-4060	264	21	promoting	promote	VERB
gs-4060	264	22	cytotoxic	cytotoxic	ADJ
gs-4060	264	23	immune	immune	ADJ
gs-4060	264	24	responses	response	NOUN
gs-4060	264	25	.	.	PUNCT
gs-4060	265	1	mek	mek	PROPN
gs-4060	265	2	inhibitors	inhibitor	NOUN
gs-4060	265	3	like	like	ADP
gs-4060	265	4	mirdametinib	mirdametinib	ADJ
gs-4060	265	5	target	target	NOUN
gs-4060	265	6	the	the	DET
gs-4060	265	7	ras	ras	PROPN
gs-4060	265	8	/	/	SYM
gs-4060	265	9	mapk	mapk	NOUN
gs-4060	265	10	pathway	pathway	NOUN
gs-4060	265	11	,	,	PUNCT
gs-4060	265	12	critical	critical	ADJ
gs-4060	265	13	in	in	ADP
gs-4060	265	14	neurofibromatosis	neurofibromatosis	NOUN
gs-4060	265	15	type	type	NOUN
gs-4060	265	16	1	1	NUM
gs-4060	265	17	.	.	NOUN
gs-4060	265	18	natural	natural	ADJ
gs-4060	265	19	compounds	compound	NOUN
gs-4060	265	20	and	and	CCONJ
gs-4060	265	21	repurposed	repurpose	VERB
gs-4060	265	22	drugs	drug	NOUN
gs-4060	265	23	exhibit	exhibit	VERB
gs-4060	265	24	multitargeted	multitargete	VERB
gs-4060	265	25	effects	effect	NOUN
gs-4060	265	26	.	.	PUNCT
gs-4060	266	1	peptides	peptide	NOUN
gs-4060	266	2	,	,	PUNCT
gs-4060	266	3	for	for	ADP
gs-4060	266	4	instance	instance	NOUN
gs-4060	266	5	,	,	PUNCT
gs-4060	266	6	enhance	enhance	VERB
gs-4060	266	7	chemotherapy	chemotherapy	NOUN
gs-4060	266	8	efficacy	efficacy	NOUN
gs-4060	266	9	while	while	SCONJ
gs-4060	266	10	reducing	reduce	VERB
gs-4060	266	11	resistance	resistance	NOUN
gs-4060	266	12	by	by	ADP
gs-4060	266	13	modulating	modulate	VERB
gs-4060	266	14	signaling	signal	VERB
gs-4060	266	15	pathways	pathway	NOUN
gs-4060	266	16	.	.	PUNCT
gs-4060	267	1	anthracyclines	anthracycline	NOUN
gs-4060	267	2	like	like	ADP
gs-4060	267	3	doxorubicin	doxorubicin	PROPN
gs-4060	267	4	intercalate	intercalate	PROPN
gs-4060	267	5	dna	dna	PROPN
gs-4060	267	6	and	and	CCONJ
gs-4060	267	7	damage	damage	NOUN
gs-4060	267	8	chromatin	chromatin	NOUN
gs-4060	267	9	,	,	PUNCT
gs-4060	267	10	disrupting	disrupt	VERB
gs-4060	267	11	replication	replication	NOUN
gs-4060	267	12	.	.	PUNCT
gs-4060	268	1	off	off	ADP
gs-4060	268	2	-	-	PUNCT
gs-4060	268	3	target	target	NOUN
gs-4060	268	4	effects	effect	NOUN
gs-4060	268	5	contribute	contribute	VERB
gs-4060	268	6	to	to	ADP
gs-4060	268	7	both	both	DET
gs-4060	268	8	efficacy	efficacy	NOUN
gs-4060	268	9	and	and	CCONJ
gs-4060	268	10	toxicity	toxicity	NOUN
gs-4060	268	11	,	,	PUNCT
gs-4060	268	12	necessitating	necessitate	VERB
gs-4060	268	13	careful	careful	ADJ
gs-4060	268	14	design	design	NOUN
gs-4060	268	15	.	.	PUNCT
gs-4060	269	1	resistance	resistance	NOUN
gs-4060	269	2	mechanisms	mechanism	NOUN
gs-4060	269	3	include	include	VERB
gs-4060	269	4	drug	drug	NOUN
gs-4060	269	5	inactivation	inactivation	NOUN
gs-4060	269	6	,	,	PUNCT
gs-4060	269	7	efflux	efflux	VERB
gs-4060	269	8	pump	pump	NOUN
gs-4060	269	9	upregulation	upregulation	NOUN
gs-4060	269	10	,	,	PUNCT
gs-4060	269	11	and	and	CCONJ
gs-4060	269	12	pathway	pathway	NOUN
gs-4060	269	13	alterations	alteration	NOUN
gs-4060	269	14	(	(	PUNCT
gs-4060	269	15	e.g.	e.g.	ADV
gs-4060	269	16	,	,	PUNCT
gs-4060	269	17	egfr	egfr	ADJ
gs-4060	269	18	mutations	mutation	NOUN
gs-4060	269	19	)	)	PUNCT
gs-4060	269	20	,	,	PUNCT
gs-4060	269	21	which	which	PRON
gs-4060	269	22	limit	limit	VERB
gs-4060	269	23	long	long	ADJ
gs-4060	269	24	-	-	PUNCT
gs-4060	269	25	term	term	NOUN
gs-4060	269	26	efficacy	efficacy	NOUN
gs-4060	269	27	.	.	PUNCT
gs-4060	270	1	recent	recent	ADJ
gs-4060	270	2	studies	study	NOUN
gs-4060	270	3	advocate	advocate	VERB
gs-4060	270	4	for	for	ADP
gs-4060	270	5	chromatin	chromatin	NOUN
gs-4060	270	6	-	-	PUNCT
gs-4060	270	7	damaging	damage	VERB
gs-4060	270	8	agents	agent	NOUN
gs-4060	270	9	to	to	PART
gs-4060	270	10	minimize	minimize	VERB
gs-4060	270	11	systemic	systemic	ADJ
gs-4060	270	12	toxicity	toxicity	NOUN
gs-4060	270	13	,	,	PUNCT
gs-4060	270	14	offering	offer	VERB
gs-4060	270	15	a	a	DET
gs-4060	270	16	novel	novel	ADJ
gs-4060	270	17	approach	approach	NOUN
gs-4060	270	18	to	to	PART
gs-4060	270	19	improve	improve	VERB
gs-4060	270	20	safety	safety	NOUN
gs-4060	270	21	profiles	profile	NOUN
gs-4060	270	22	.	.	PUNCT
gs-4060	271	1	pharmacology	pharmacology	NOUN
gs-4060	271	2	and	and	CCONJ
gs-4060	271	3	clinical	clinical	ADJ
gs-4060	271	4	use	use	NOUN
gs-4060	271	5	pharmacologically	pharmacologically	ADV
gs-4060	271	6	,	,	PUNCT
gs-4060	271	7	small	small	ADJ
gs-4060	271	8	molecules	molecule	NOUN
gs-4060	271	9	like	like	ADP
gs-4060	271	10	acalabrutinib	acalabrutinib	NOUN
gs-4060	271	11	,	,	PUNCT
gs-4060	271	12	a	a	DET
gs-4060	271	13	bruton	bruton	PROPN
gs-4060	271	14	’s	’s	PART
gs-4060	271	15	tyrosine	tyrosine	PROPN
gs-4060	271	16	kinase	kinase	PROPN
gs-4060	271	17	(	(	PUNCT
gs-4060	271	18	btk	btk	PROPN
gs-4060	271	19	)	)	PUNCT
gs-4060	271	20	inhibitor	inhibitor	NOUN
gs-4060	271	21	,	,	PUNCT
gs-4060	271	22	offer	offer	VERB
gs-4060	271	23	high	high	ADJ
gs-4060	271	24	oral	oral	ADJ
gs-4060	271	25	bioavailability	bioavailability	NOUN
gs-4060	271	26	and	and	CCONJ
gs-4060	271	27	selectivity	selectivity	NOUN
gs-4060	271	28	,	,	PUNCT
gs-4060	271	29	used	use	VERB
gs-4060	271	30	in	in	ADP
gs-4060	271	31	mantle	mantle	ADJ
gs-4060	271	32	cell	cell	NOUN
gs-4060	271	33	lymphoma	lymphoma	NOUN
gs-4060	271	34	.	.	PUNCT
gs-4060	272	1	biologics	biologic	NOUN
gs-4060	272	2	,	,	PUNCT
gs-4060	272	3	such	such	ADJ
gs-4060	272	4	as	as	ADP
gs-4060	272	5	pembrolizumab	pembrolizumab	NOUN
gs-4060	272	6	and	and	CCONJ
gs-4060	272	7	adcs	adcs	ADJ
gs-4060	272	8	,	,	PUNCT
gs-4060	272	9	require	require	VERB
gs-4060	272	10	intravenous	intravenous	ADJ
gs-4060	272	11	administration	administration	NOUN
gs-4060	272	12	,	,	PUNCT
gs-4060	272	13	with	with	ADP
gs-4060	272	14	half	half	ADJ
gs-4060	272	15	-	-	PUNCT
gs-4060	272	16	lives	life	NOUN
gs-4060	272	17	ranging	range	VERB
gs-4060	272	18	from	from	ADP
gs-4060	272	19	days	day	NOUN
gs-4060	272	20	to	to	ADP
gs-4060	272	21	weeks	week	NOUN
gs-4060	272	22	,	,	PUNCT
gs-4060	272	23	influencing	influence	VERB
gs-4060	272	24	dosing	dose	VERB
gs-4060	272	25	schedules	schedule	NOUN
gs-4060	272	26	.	.	PUNCT
gs-4060	273	1	drug	drug	NOUN
gs-4060	273	2	delivery	delivery	NOUN
gs-4060	273	3	systems	system	NOUN
gs-4060	273	4	,	,	PUNCT
gs-4060	273	5	including	include	VERB
gs-4060	273	6	nanoparticles	nanoparticle	NOUN
gs-4060	273	7	and	and	CCONJ
gs-4060	273	8	cleavable	cleavable	ADJ
gs-4060	273	9	linkers	linker	NOUN
gs-4060	273	10	in	in	ADP
gs-4060	273	11	adcs	adcs	ADV
gs-4060	273	12	,	,	PUNCT
gs-4060	273	13	enhance	enhance	VERB
gs-4060	273	14	tumor	tumor	NOUN
gs-4060	273	15	specificity	specificity	NOUN
gs-4060	273	16	and	and	CCONJ
gs-4060	273	17	reduce	reduce	VERB
gs-4060	273	18	systemic	systemic	ADJ
gs-4060	273	19	exposure	exposure	NOUN
gs-4060	273	20	.	.	PUNCT
gs-4060	274	1	clinical	clinical	ADJ
gs-4060	274	2	use	use	NOUN
gs-4060	274	3	is	be	AUX
gs-4060	274	4	increasingly	increasingly	ADV
gs-4060	274	5	biomarker	biomarker	NOUN
gs-4060	274	6	-	-	PUNCT
gs-4060	274	7	driven	drive	VERB
gs-4060	274	8	.	.	PUNCT
gs-4060	275	1	datopotamab	datopotamab	NOUN
gs-4060	275	2	deruxtecan	deruxtecan	ADJ
gs-4060	275	3	targets	target	NOUN
gs-4060	275	4	trop2	trop2	ADV
gs-4060	275	5	in	in	ADP
gs-4060	275	6	nsclc	nsclc	NOUN
gs-4060	275	7	,	,	PUNCT
gs-4060	275	8	achieving	achieve	VERB
gs-4060	275	9	significant	significant	ADJ
gs-4060	275	10	response	response	NOUN
gs-4060	275	11	rates	rate	NOUN
gs-4060	275	12	in	in	ADP
gs-4060	275	13	pretreated	pretreated	ADJ
gs-4060	275	14	patients	patient	NOUN
gs-4060	275	15	.	.	PUNCT
gs-4060	276	1	combinations	combination	NOUN
gs-4060	276	2	,	,	PUNCT
gs-4060	276	3	such	such	ADJ
gs-4060	276	4	as	as	ADP
gs-4060	276	5	encorafenib	encorafenib	NOUN
gs-4060	276	6	with	with	ADP
gs-4060	276	7	cetuximab	cetuximab	NOUN
gs-4060	276	8	,	,	PUNCT
gs-4060	276	9	improve	improve	VERB
gs-4060	276	10	progression	progression	NOUN
gs-4060	276	11	-	-	PUNCT
gs-4060	276	12	free	free	ADJ
gs-4060	276	13	survival	survival	NOUN
gs-4060	276	14	in	in	ADP
gs-4060	276	15	braf	braf	NOUN
gs-4060	276	16	-	-	PUNCT
gs-4060	276	17	mutated	mutate	VERB
gs-4060	276	18	colorectal	colorectal	ADJ
gs-4060	276	19	cancer	cancer	NOUN
gs-4060	276	20	.	.	PUNCT
gs-4060	277	1	repurposed	repurpose	VERB
gs-4060	277	2	drugs	drug	NOUN
gs-4060	277	3	,	,	PUNCT
gs-4060	277	4	like	like	ADP
gs-4060	277	5	metformin	metformin	NOUN
gs-4060	277	6	,	,	PUNCT
gs-4060	277	7	leverage	leverage	NOUN
gs-4060	277	8	metabolic	metabolic	NOUN
gs-4060	277	9	vulnerabilities	vulnerability	NOUN
gs-4060	277	10	,	,	PUNCT
gs-4060	277	11	offering	offer	VERB
gs-4060	277	12	cost	cost	NOUN
gs-4060	277	13	-	-	PUNCT
gs-4060	277	14	effective	effective	ADJ
gs-4060	277	15	options	option	NOUN
gs-4060	277	16	with	with	ADP
gs-4060	277	17	reduced	reduced	ADJ
gs-4060	277	18	toxicity	toxicity	NOUN
gs-4060	277	19	.	.	PUNCT
gs-4060	278	1	natural	natural	ADJ
gs-4060	278	2	compounds	compound	NOUN
gs-4060	278	3	,	,	PUNCT
gs-4060	278	4	such	such	ADJ
gs-4060	278	5	as	as	ADP
gs-4060	278	6	curcumin	curcumin	NOUN
gs-4060	278	7	,	,	PUNCT
gs-4060	278	8	modulate	modulate	VERB
gs-4060	278	9	pathways	pathway	NOUN
gs-4060	278	10	like	like	ADP
gs-4060	278	11	pi3k	pi3k	PROPN
gs-4060	278	12	/	/	SYM
gs-4060	278	13	akt	akt	PROPN
gs-4060	278	14	/	/	SYM
gs-4060	278	15	mtor	mtor	PROPN
gs-4060	278	16	,	,	PUNCT
gs-4060	278	17	showing	show	VERB
gs-4060	278	18	promise	promise	NOUN
gs-4060	278	19	in	in	ADP
gs-4060	278	20	preclinical	preclinical	ADJ
gs-4060	278	21	models	model	NOUN
gs-4060	278	22	.	.	PUNCT
gs-4060	279	1	drug	drug	NOUN
gs-4060	279	2	interactions	interaction	NOUN
gs-4060	279	3	,	,	PUNCT
gs-4060	279	4	particularly	particularly	ADV
gs-4060	279	5	via	via	ADP
gs-4060	279	6	georgian	georgian	PROPN
gs-4060	279	7	scientists/	scientists/	NUM
gs-4060	279	8	.	.	PUNCT
gs-4060	280	1	7	7	NUM
gs-4060	280	2	n	n	PRON
gs-4060	280	3	3	3	NUM
gs-4060	280	4	,	,	PUNCT
gs-4060	280	5	2025	2025	NUM
gs-4060	280	6	583	583	NUM
gs-4060	280	7	cyp3a4	cyp3a4	NOUN
gs-4060	280	8	metabolism	metabolism	NOUN
gs-4060	280	9	,	,	PUNCT
gs-4060	280	10	affect	affect	VERB
gs-4060	280	11	tki	tki	NOUN
gs-4060	280	12	pharmacokinetics	pharmacokinetic	NOUN
gs-4060	280	13	,	,	PUNCT
gs-4060	280	14	requiring	require	VERB
gs-4060	280	15	careful	careful	ADJ
gs-4060	280	16	monitoring	monitoring	NOUN
gs-4060	280	17	.	.	PUNCT
gs-4060	281	1	class	class	NOUN
gs-4060	281	2	effects	effect	NOUN
gs-4060	281	3	,	,	PUNCT
gs-4060	281	4	such	such	ADJ
gs-4060	281	5	as	as	ADP
gs-4060	281	6	shared	share	VERB
gs-4060	281	7	toxicities	toxicity	NOUN
gs-4060	281	8	among	among	ADP
gs-4060	281	9	cdk4/6	cdk4/6	PROPN
gs-4060	281	10	inhibitors	inhibitor	NOUN
gs-4060	281	11	,	,	PUNCT
gs-4060	281	12	allow	allow	VERB
gs-4060	281	13	interchangeability	interchangeability	NOUN
gs-4060	281	14	but	but	CCONJ
gs-4060	281	15	demand	demand	NOUN
gs-4060	281	16	vigilance	vigilance	NOUN
gs-4060	281	17	.	.	PUNCT
gs-4060	282	1	therapeutic	therapeutic	ADJ
gs-4060	282	2	effects	effect	NOUN
gs-4060	282	3	therapeutic	therapeutic	ADJ
gs-4060	282	4	effects	effect	NOUN
gs-4060	282	5	are	be	AUX
gs-4060	282	6	evidenced	evidence	VERB
gs-4060	282	7	by	by	ADP
gs-4060	282	8	improved	improve	VERB
gs-4060	282	9	objective	objective	ADJ
gs-4060	282	10	response	response	NOUN
gs-4060	282	11	rates	rate	NOUN
gs-4060	282	12	(	(	PUNCT
gs-4060	282	13	orr	orr	PROPN
gs-4060	282	14	)	)	PUNCT
gs-4060	282	15	and	and	CCONJ
gs-4060	282	16	overall	overall	ADJ
gs-4060	282	17	survival	survival	NOUN
gs-4060	282	18	(	(	PUNCT
gs-4060	282	19	os	os	NOUN
gs-4060	282	20	)	)	PUNCT
gs-4060	282	21	.	.	PUNCT
gs-4060	283	1	pembrolizumab	pembrolizumab	NOUN
gs-4060	283	2	demonstrates	demonstrate	VERB
gs-4060	283	3	durable	durable	ADJ
gs-4060	283	4	responses	response	NOUN
gs-4060	283	5	in	in	ADP
gs-4060	283	6	gastric	gastric	NOUN
gs-4060	283	7	/	/	SYM
gs-4060	283	8	gej	gej	PROPN
gs-4060	283	9	adenocarcinoma	adenocarcinoma	NOUN
gs-4060	283	10	,	,	PUNCT
gs-4060	283	11	with	with	ADP
gs-4060	283	12	orr	orr	NOUN
gs-4060	283	13	exceeding	exceed	VERB
gs-4060	283	14	30	30	NUM
gs-4060	283	15	%	%	NOUN
gs-4060	283	16	in	in	ADP
gs-4060	283	17	msi	msi	PROPN
gs-4060	283	18	-	-	PROPN
gs-4060	283	19	h	h	NOUN
gs-4060	283	20	tumors	tumor	NOUN
gs-4060	283	21	.	.	PUNCT
gs-4060	284	1	adcs	adc	VERB
gs-4060	284	2	like	like	ADP
gs-4060	284	3	trastuzumab	trastuzumab	NOUN
gs-4060	284	4	deruxtecan	deruxtecan	AUX
gs-4060	284	5	achieve	achieve	VERB
gs-4060	284	6	orr	orr	NOUN
gs-4060	284	7	above	above	ADP
gs-4060	284	8	40	40	NUM
gs-4060	284	9	%	%	NOUN
gs-4060	284	10	in	in	ADP
gs-4060	284	11	her2	her2	PROPN
gs-4060	284	12	-	-	PUNCT
gs-4060	284	13	low	low	ADJ
gs-4060	284	14	breast	breast	NOUN
gs-4060	284	15	cancer	cancer	NOUN
gs-4060	284	16	,	,	PUNCT
gs-4060	284	17	expanding	expand	VERB
gs-4060	284	18	treatment	treatment	NOUN
gs-4060	284	19	options	option	NOUN
gs-4060	284	20	.	.	PUNCT
gs-4060	285	1	in	in	ADP
gs-4060	285	2	a	a	DET
gs-4060	285	3	comprehensive	comprehensive	ADJ
gs-4060	285	4	analysis	analysis	NOUN
gs-4060	285	5	of	of	ADP
gs-4060	285	6	52	52	NUM
gs-4060	285	7	drugs	drug	NOUN
gs-4060	285	8	approved	approve	VERB
gs-4060	285	9	between	between	ADP
gs-4060	285	10	2019	2019	NUM
gs-4060	285	11	and	and	CCONJ
gs-4060	285	12	2022	2022	NUM
gs-4060	285	13	,	,	PUNCT
gs-4060	285	14	213	213	NUM
gs-4060	285	15	clinical	clinical	ADJ
gs-4060	285	16	endpoints	endpoint	NOUN
gs-4060	285	17	were	be	AUX
gs-4060	285	18	identified	identify	VERB
gs-4060	285	19	,	,	PUNCT
gs-4060	285	20	including	include	VERB
gs-4060	285	21	os	os	NOUN
gs-4060	285	22	,	,	PUNCT
gs-4060	285	23	progressionfree	progressionfree	ADJ
gs-4060	285	24	survival	survival	NOUN
gs-4060	285	25	,	,	PUNCT
gs-4060	285	26	and	and	CCONJ
gs-4060	285	27	orr	orr	PROPN
gs-4060	285	28	,	,	PUNCT
gs-4060	285	29	though	though	SCONJ
gs-4060	285	30	many	many	ADJ
gs-4060	285	31	trials	trial	NOUN
gs-4060	285	32	lacked	lack	VERB
gs-4060	285	33	placebo	placebo	NOUN
gs-4060	285	34	controls	control	NOUN
gs-4060	285	35	,	,	PUNCT
gs-4060	285	36	complicating	complicate	VERB
gs-4060	285	37	efficacy	efficacy	NOUN
gs-4060	285	38	assessments	assessment	NOUN
gs-4060	285	39	.	.	PUNCT
gs-4060	286	1	mechanistically	mechanistically	ADV
gs-4060	286	2	,	,	PUNCT
gs-4060	286	3	these	these	DET
gs-4060	286	4	drugs	drug	NOUN
gs-4060	286	5	induce	induce	VERB
gs-4060	286	6	apoptosis	apoptosis	NOUN
gs-4060	286	7	,	,	PUNCT
gs-4060	286	8	inhibit	inhibit	NOUN
gs-4060	286	9	angiogenesis	angiogenesis	NOUN
gs-4060	286	10	,	,	PUNCT
gs-4060	286	11	or	or	CCONJ
gs-4060	286	12	activate	activate	VERB
gs-4060	286	13	immune	immune	ADJ
gs-4060	286	14	responses	response	NOUN
gs-4060	286	15	.	.	PUNCT
gs-4060	287	1	ion	ion	NOUN
gs-4060	287	2	channel	channel	NOUN
gs-4060	287	3	modulators	modulator	NOUN
gs-4060	287	4	,	,	PUNCT
gs-4060	287	5	an	an	DET
gs-4060	287	6	emerging	emerge	VERB
gs-4060	287	7	class	class	NOUN
gs-4060	287	8	,	,	PUNCT
gs-4060	287	9	alter	alter	VERB
gs-4060	287	10	tumor	tumor	NOUN
gs-4060	287	11	cell	cell	NOUN
gs-4060	287	12	membrane	membrane	NOUN
gs-4060	287	13	potentials	potential	NOUN
gs-4060	287	14	,	,	PUNCT
gs-4060	287	15	enhancing	enhance	VERB
gs-4060	287	16	cytotoxic	cytotoxic	ADJ
gs-4060	287	17	effects	effect	NOUN
gs-4060	287	18	.	.	PUNCT
gs-4060	288	1	combination	combination	NOUN
gs-4060	288	2	therapies	therapy	NOUN
gs-4060	288	3	,	,	PUNCT
gs-4060	288	4	such	such	ADJ
gs-4060	288	5	as	as	ADP
gs-4060	288	6	checkpoint	checkpoint	NOUN
gs-4060	288	7	inhibitors	inhibitor	NOUN
gs-4060	288	8	with	with	ADP
gs-4060	288	9	tkis	tkis	NOUN
gs-4060	288	10	,	,	PUNCT
gs-4060	288	11	synergize	synergize	VERB
gs-4060	288	12	to	to	PART
gs-4060	288	13	improve	improve	VERB
gs-4060	288	14	outcomes	outcome	NOUN
gs-4060	288	15	,	,	PUNCT
gs-4060	288	16	particularly	particularly	ADV
gs-4060	288	17	in	in	ADP
gs-4060	288	18	nsclc	nsclc	NOUN
gs-4060	288	19	and	and	CCONJ
gs-4060	288	20	melanoma	melanoma	NOUN
gs-4060	288	21	.	.	PUNCT
gs-4060	289	1	natural	natural	ADJ
gs-4060	289	2	products	product	NOUN
gs-4060	289	3	like	like	ADP
gs-4060	289	4	artemisinin	artemisinin	NOUN
gs-4060	289	5	derivatives	derivative	NOUN
gs-4060	289	6	upregulate	upregulate	VERB
gs-4060	289	7	tumor	tumor	NOUN
gs-4060	289	8	suppressors	suppressor	NOUN
gs-4060	289	9	,	,	PUNCT
gs-4060	289	10	while	while	SCONJ
gs-4060	289	11	repurposed	repurposed	ADJ
gs-4060	289	12	drugs	drug	NOUN
gs-4060	289	13	like	like	ADP
gs-4060	289	14	disulfiram	disulfiram	NOUN
gs-4060	289	15	inhibit	inhibit	NOUN
gs-4060	289	16	glycolysis	glycolysis	NOUN
gs-4060	289	17	,	,	PUNCT
gs-4060	289	18	offering	offer	VERB
gs-4060	289	19	novel	novel	ADJ
gs-4060	289	20	mechanisms	mechanism	NOUN
gs-4060	289	21	.	.	PUNCT
gs-4060	290	1	these	these	DET
gs-4060	290	2	effects	effect	NOUN
gs-4060	290	3	collectively	collectively	ADV
gs-4060	290	4	shift	shift	VERB
gs-4060	290	5	treatment	treatment	NOUN
gs-4060	290	6	paradigms	paradigm	NOUN
gs-4060	290	7	toward	toward	ADP
gs-4060	290	8	less	less	ADV
gs-4060	290	9	toxic	toxic	ADJ
gs-4060	290	10	,	,	PUNCT
gs-4060	290	11	more	more	ADV
gs-4060	290	12	effective	effective	ADJ
gs-4060	290	13	regimens	regimen	NOUN
gs-4060	290	14	,	,	PUNCT
gs-4060	290	15	aligning	align	VERB
gs-4060	290	16	with	with	ADP
gs-4060	290	17	precision	precision	NOUN
gs-4060	290	18	medicine	medicine	NOUN
gs-4060	290	19	goals	goal	NOUN
gs-4060	290	20	.	.	PUNCT
gs-4060	291	1	toxicities	toxicity	NOUN
gs-4060	291	2	and	and	CCONJ
gs-4060	291	3	side	side	NOUN
gs-4060	291	4	effects	effect	NOUN
gs-4060	291	5	toxicities	toxicity	NOUN
gs-4060	291	6	remain	remain	VERB
gs-4060	291	7	a	a	DET
gs-4060	291	8	significant	significant	ADJ
gs-4060	291	9	challenge	challenge	NOUN
gs-4060	291	10	.	.	PUNCT
gs-4060	292	1	adcs	adc	VERB
gs-4060	292	2	like	like	ADP
gs-4060	292	3	trastuzumab	trastuzumab	NOUN
gs-4060	292	4	deruxtecan	deruxtecan	PROPN
gs-4060	292	5	are	be	AUX
gs-4060	292	6	associated	associate	VERB
gs-4060	292	7	with	with	ADP
gs-4060	292	8	interstitial	interstitial	ADJ
gs-4060	292	9	lung	lung	NOUN
gs-4060	292	10	disease	disease	NOUN
gs-4060	292	11	and	and	CCONJ
gs-4060	292	12	neutropenia	neutropenia	NOUN
gs-4060	292	13	,	,	PUNCT
gs-4060	292	14	requiring	require	VERB
gs-4060	292	15	proactive	proactive	ADJ
gs-4060	292	16	monitoring	monitoring	NOUN
gs-4060	292	17	.	.	PUNCT
gs-4060	293	1	tkis	tkis	PROPN
gs-4060	293	2	such	such	ADJ
gs-4060	293	3	as	as	ADP
gs-4060	293	4	acalabrutinib	acalabrutinib	NOUN
gs-4060	293	5	cause	cause	VERB
gs-4060	293	6	bleeding	bleed	VERB
gs-4060	293	7	risks	risk	NOUN
gs-4060	293	8	and	and	CCONJ
gs-4060	293	9	infections	infection	NOUN
gs-4060	293	10	,	,	PUNCT
gs-4060	293	11	particularly	particularly	ADV
gs-4060	293	12	in	in	ADP
gs-4060	293	13	immunocompromised	immunocompromise	VERB
gs-4060	293	14	patients	patient	NOUN
gs-4060	293	15	.	.	PUNCT
gs-4060	294	1	immune	immune	ADJ
gs-4060	294	2	checkpoint	checkpoint	NOUN
gs-4060	294	3	inhibitors	inhibitor	NOUN
gs-4060	294	4	induce	induce	VERB
gs-4060	294	5	immune	immune	NOUN
gs-4060	294	6	-	-	PUNCT
gs-4060	294	7	related	relate	VERB
gs-4060	294	8	adverse	adverse	ADJ
gs-4060	294	9	events	event	NOUN
gs-4060	294	10	,	,	PUNCT
gs-4060	294	11	including	include	VERB
gs-4060	294	12	colitis	colitis	NOUN
gs-4060	294	13	and	and	CCONJ
gs-4060	294	14	pneumonitis	pneumonitis	NOUN
gs-4060	294	15	,	,	PUNCT
gs-4060	294	16	with	with	ADP
gs-4060	294	17	incidence	incidence	NOUN
gs-4060	294	18	rates	rate	NOUN
gs-4060	294	19	up	up	ADV
gs-4060	294	20	to	to	PART
gs-4060	294	21	20	20	NUM
gs-4060	294	22	%	%	NOUN
gs-4060	294	23	in	in	ADP
gs-4060	294	24	some	some	DET
gs-4060	294	25	cohorts	cohort	NOUN
gs-4060	294	26	.	.	PUNCT
gs-4060	295	1	anthracyclines	anthracycline	NOUN
gs-4060	295	2	contribute	contribute	VERB
gs-4060	295	3	to	to	ADP
gs-4060	295	4	cardiotoxicity	cardiotoxicity	NOUN
gs-4060	295	5	,	,	PUNCT
gs-4060	295	6	limiting	limit	VERB
gs-4060	295	7	cumulative	cumulative	ADJ
gs-4060	295	8	doses	dose	NOUN
gs-4060	295	9	.	.	PUNCT
gs-4060	296	1	off	off	ADP
gs-4060	296	2	-	-	PUNCT
gs-4060	296	3	target	target	NOUN
gs-4060	296	4	effects	effect	NOUN
gs-4060	296	5	are	be	AUX
gs-4060	296	6	a	a	DET
gs-4060	296	7	leading	lead	VERB
gs-4060	296	8	cause	cause	NOUN
gs-4060	296	9	of	of	ADP
gs-4060	296	10	clinical	clinical	ADJ
gs-4060	296	11	trial	trial	NOUN
gs-4060	296	12	failures	failure	NOUN
gs-4060	296	13	,	,	PUNCT
gs-4060	296	14	with	with	ADP
gs-4060	296	15	over	over	ADP
gs-4060	296	16	90	90	NUM
gs-4060	296	17	%	%	NOUN
gs-4060	296	18	of	of	ADP
gs-4060	296	19	candidates	candidate	NOUN
gs-4060	296	20	failing	fail	VERB
gs-4060	296	21	due	due	ADP
gs-4060	296	22	to	to	ADP
gs-4060	296	23	toxicity	toxicity	NOUN
gs-4060	296	24	or	or	CCONJ
gs-4060	296	25	insufficient	insufficient	ADJ
gs-4060	296	26	efficacy	efficacy	NOUN
gs-4060	296	27	.	.	PUNCT
gs-4060	297	1	strategies	strategy	NOUN
gs-4060	297	2	to	to	PART
gs-4060	297	3	mitigate	mitigate	VERB
gs-4060	297	4	toxicity	toxicity	NOUN
gs-4060	297	5	include	include	VERB
gs-4060	297	6	neutralizing	neutralize	VERB
gs-4060	297	7	cell	cell	NOUN
gs-4060	297	8	-	-	PUNCT
gs-4060	297	9	free	free	ADJ
gs-4060	297	10	chromatin	chromatin	NOUN
gs-4060	297	11	to	to	PART
gs-4060	297	12	reduce	reduce	VERB
gs-4060	297	13	chemotherapy	chemotherapy	NOUN
gs-4060	297	14	-	-	PUNCT
gs-4060	297	15	induced	induce	VERB
gs-4060	297	16	systemic	systemic	ADJ
gs-4060	297	17	damage	damage	NOUN
gs-4060	297	18	.	.	PUNCT
gs-4060	298	1	newer	new	ADJ
gs-4060	298	2	agents	agent	NOUN
gs-4060	298	3	,	,	PUNCT
gs-4060	298	4	like	like	ADP
gs-4060	298	5	suzetrigine	suzetrigine	NOUN
gs-4060	298	6	,	,	PUNCT
gs-4060	298	7	cause	cause	VERB
gs-4060	298	8	drowsiness	drowsiness	NOUN
gs-4060	298	9	and	and	CCONJ
gs-4060	298	10	gastrointestinal	gastrointestinal	ADJ
gs-4060	298	11	upset	upset	ADJ
gs-4060	298	12	,	,	PUNCT
gs-4060	298	13	necessitating	necessitate	VERB
gs-4060	298	14	supportive	supportive	ADJ
gs-4060	298	15	care	care	NOUN
gs-4060	298	16	.	.	PUNCT
gs-4060	299	1	combination	combination	NOUN
gs-4060	299	2	therapies	therapy	NOUN
gs-4060	299	3	reduce	reduce	VERB
gs-4060	299	4	individual	individual	ADJ
gs-4060	299	5	drug	drug	NOUN
gs-4060	299	6	dosages	dosage	NOUN
gs-4060	299	7	,	,	PUNCT
gs-4060	299	8	mitigating	mitigate	VERB
gs-4060	299	9	toxicities	toxicity	NOUN
gs-4060	299	10	while	while	SCONJ
gs-4060	299	11	maintaining	maintain	VERB
gs-4060	299	12	efficacy	efficacy	NOUN
gs-4060	299	13	.	.	PUNCT
gs-4060	300	1	understanding	understand	VERB
gs-4060	300	2	class	class	NOUN
gs-4060	300	3	effects	effect	NOUN
gs-4060	300	4	,	,	PUNCT
gs-4060	300	5	such	such	ADJ
gs-4060	300	6	as	as	ADP
gs-4060	300	7	myelosuppression	myelosuppression	NOUN
gs-4060	300	8	in	in	ADP
gs-4060	300	9	alkylating	alkylate	VERB
gs-4060	300	10	agents	agent	NOUN
gs-4060	300	11	,	,	PUNCT
gs-4060	300	12	aids	aid	NOUN
gs-4060	300	13	in	in	ADP
gs-4060	300	14	predicting	predict	VERB
gs-4060	300	15	and	and	CCONJ
gs-4060	300	16	managing	manage	VERB
gs-4060	300	17	adverse	adverse	ADJ
gs-4060	300	18	events	event	NOUN
gs-4060	300	19	.	.	PUNCT
gs-4060	301	1	pharmacogenomic	pharmacogenomic	ADJ
gs-4060	301	2	profiling	profiling	NOUN
gs-4060	301	3	further	far	ADV
gs-4060	301	4	optimizes	optimize	VERB
gs-4060	301	5	dosing	dose	VERB
gs-4060	301	6	to	to	PART
gs-4060	301	7	minimize	minimize	VERB
gs-4060	301	8	toxicity	toxicity	NOUN
gs-4060	301	9	in	in	ADP
gs-4060	301	10	diverse	diverse	ADJ
gs-4060	301	11	patient	patient	ADJ
gs-4060	301	12	populations	population	NOUN
gs-4060	301	13	.	.	PUNCT
gs-4060	302	1	discussion	discussion	NOUN
gs-4060	302	2	on	on	ADP
gs-4060	302	3	challenges	challenge	NOUN
gs-4060	302	4	and	and	CCONJ
gs-4060	302	5	future	future	ADJ
gs-4060	302	6	directions	direction	NOUN
gs-4060	302	7	despite	despite	SCONJ
gs-4060	302	8	advancements	advancement	NOUN
gs-4060	302	9	,	,	PUNCT
gs-4060	302	10	only	only	ADV
gs-4060	302	11	about	about	ADV
gs-4060	302	12	50	50	NUM
gs-4060	302	13	%	%	NOUN
gs-4060	302	14	of	of	ADP
gs-4060	302	15	critical	critical	ADJ
gs-4060	302	16	clinical	clinical	ADJ
gs-4060	302	17	trials	trial	NOUN
gs-4060	302	18	for	for	ADP
gs-4060	302	19	new	new	ADJ
gs-4060	302	20	anticancer	anticancer	NOUN
gs-4060	302	21	drugs	drug	NOUN
gs-4060	302	22	are	be	AUX
gs-4060	302	23	completed	complete	VERB
gs-4060	302	24	before	before	ADP
gs-4060	302	25	approval	approval	NOUN
gs-4060	302	26	,	,	PUNCT
gs-4060	302	27	raising	raise	VERB
gs-4060	302	28	concerns	concern	NOUN
gs-4060	302	29	about	about	ADP
gs-4060	302	30	long	long	ADJ
gs-4060	302	31	-	-	PUNCT
gs-4060	302	32	term	term	NOUN
gs-4060	302	33	efficacy	efficacy	NOUN
gs-4060	302	34	and	and	CCONJ
gs-4060	302	35	safety	safety	NOUN
gs-4060	302	36	data	datum	NOUN
gs-4060	302	37	.	.	PUNCT
gs-4060	303	1	resistance	resistance	NOUN
gs-4060	303	2	,	,	PUNCT
gs-4060	303	3	driven	drive	VERB
gs-4060	303	4	by	by	ADP
gs-4060	303	5	mechanisms	mechanism	NOUN
gs-4060	303	6	like	like	ADP
gs-4060	303	7	target	target	NOUN
gs-4060	303	8	mutations	mutation	NOUN
gs-4060	303	9	and	and	CCONJ
gs-4060	303	10	tumor	tumor	NOUN
gs-4060	303	11	microenvironment	microenvironment	ADJ
gs-4060	303	12	adaptations	adaptation	NOUN
gs-4060	303	13	,	,	PUNCT
gs-4060	303	14	limits	limit	VERB
gs-4060	303	15	durability	durability	NOUN
gs-4060	303	16	of	of	ADP
gs-4060	303	17	responses	response	NOUN
gs-4060	303	18	.	.	PUNCT
gs-4060	304	1	toxicities	toxicity	NOUN
gs-4060	304	2	,	,	PUNCT
gs-4060	304	3	particularly	particularly	ADV
gs-4060	304	4	from	from	ADP
gs-4060	304	5	adcs	adcs	ADJ
gs-4060	304	6	and	and	CCONJ
gs-4060	304	7	immunotherapies	immunotherapy	NOUN
gs-4060	304	8	,	,	PUNCT
gs-4060	304	9	necessitate	necessitate	ADJ
gs-4060	304	10	improved	improve	VERB
gs-4060	304	11	management	management	NOUN
gs-4060	304	12	strategies	strategy	NOUN
gs-4060	304	13	.	.	PUNCT
gs-4060	305	1	future	future	ADJ
gs-4060	305	2	directions	direction	NOUN
gs-4060	305	3	include	include	VERB
gs-4060	305	4	leveraging	leverage	VERB
gs-4060	305	5	artificial	artificial	ADJ
gs-4060	305	6	intelligence	intelligence	NOUN
gs-4060	305	7	(	(	PUNCT
gs-4060	305	8	ai	ai	NOUN
gs-4060	305	9	)	)	PUNCT
gs-4060	305	10	for	for	ADP
gs-4060	305	11	drug	drug	NOUN
gs-4060	305	12	design	design	NOUN
gs-4060	305	13	,	,	PUNCT
gs-4060	305	14	identifying	identify	VERB
gs-4060	305	15	novel	novel	ADJ
gs-4060	305	16	targets	target	NOUN
gs-4060	305	17	,	,	PUNCT
gs-4060	305	18	and	and	CCONJ
gs-4060	305	19	optimizing	optimize	VERB
gs-4060	305	20	pharmacokinetics	pharmacokinetic	NOUN
gs-4060	305	21	.	.	PUNCT
gs-4060	306	1	microbiome	microbiome	ADJ
gs-4060	306	2	modulation	modulation	NOUN
gs-4060	306	3	is	be	AUX
gs-4060	306	4	emerging	emerge	VERB
gs-4060	306	5	as	as	ADP
gs-4060	306	6	a	a	DET
gs-4060	306	7	strategy	strategy	NOUN
gs-4060	306	8	georgian	georgian	NOUN
gs-4060	306	9	scientists/	scientists/	NUM
gs-4060	306	10	.	.	PUNCT
gs-4060	307	1	7	7	NUM
gs-4060	307	2	n	n	PRON
gs-4060	307	3	3	3	NUM
gs-4060	307	4	,	,	PUNCT
gs-4060	307	5	2025	2025	NUM
gs-4060	307	6	584	584	NUM
gs-4060	308	1	to	to	PART
gs-4060	308	2	enhance	enhance	VERB
gs-4060	308	3	immunotherapy	immunotherapy	NOUN
gs-4060	308	4	efficacy	efficacy	NOUN
gs-4060	308	5	,	,	PUNCT
gs-4060	308	6	with	with	ADP
gs-4060	308	7	gut	gut	NOUN
gs-4060	308	8	microbiota	microbiota	NOUN
gs-4060	308	9	influencing	influencing	NOUN
gs-4060	308	10	pd-1	pd-1	ADP
gs-4060	308	11	inhibitor	inhibitor	NOUN
gs-4060	308	12	responses	response	NOUN
gs-4060	308	13	.	.	PUNCT
gs-4060	309	1	natural	natural	ADJ
gs-4060	309	2	compounds	compound	NOUN
gs-4060	309	3	and	and	CCONJ
gs-4060	309	4	peptides	peptide	NOUN
gs-4060	309	5	offer	offer	VERB
gs-4060	309	6	promise	promise	NOUN
gs-4060	309	7	for	for	ADP
gs-4060	309	8	reducing	reduce	VERB
gs-4060	309	9	toxicity	toxicity	NOUN
gs-4060	309	10	and	and	CCONJ
gs-4060	309	11	overcoming	overcome	VERB
gs-4060	309	12	resistance	resistance	NOUN
gs-4060	309	13	,	,	PUNCT
gs-4060	309	14	with	with	ADP
gs-4060	309	15	preclinical	preclinical	ADJ
gs-4060	309	16	data	datum	NOUN
gs-4060	309	17	supporting	support	VERB
gs-4060	309	18	their	their	PRON
gs-4060	309	19	multitargeted	multitargete	VERB
gs-4060	309	20	effects	effect	NOUN
gs-4060	309	21	.	.	PUNCT
gs-4060	310	1	global	global	ADJ
gs-4060	310	2	access	access	NOUN
gs-4060	310	3	remains	remain	VERB
gs-4060	310	4	a	a	DET
gs-4060	310	5	critical	critical	ADJ
gs-4060	310	6	issue	issue	NOUN
gs-4060	310	7	,	,	PUNCT
gs-4060	310	8	with	with	ADP
gs-4060	310	9	high	high	ADJ
gs-4060	310	10	costs	cost	NOUN
gs-4060	310	11	of	of	ADP
gs-4060	310	12	biologics	biologic	NOUN
gs-4060	310	13	and	and	CCONJ
gs-4060	310	14	car	car	NOUN
gs-4060	310	15	-	-	PUNCT
gs-4060	310	16	t	t	NOUN
gs-4060	310	17	therapies	therapy	NOUN
gs-4060	310	18	limiting	limit	VERB
gs-4060	310	19	availability	availability	NOUN
gs-4060	310	20	in	in	ADP
gs-4060	310	21	lowand	lowand	ADJ
gs-4060	310	22	middle	middle	ADJ
gs-4060	310	23	-	-	PUNCT
gs-4060	310	24	income	income	NOUN
gs-4060	310	25	countries	country	NOUN
gs-4060	310	26	.	.	PUNCT
gs-4060	311	1	repurposing	repurpose	VERB
gs-4060	311	2	drugs	drug	NOUN
gs-4060	311	3	like	like	ADP
gs-4060	311	4	metformin	metformin	NOUN
gs-4060	311	5	and	and	CCONJ
gs-4060	311	6	developing	develop	VERB
gs-4060	311	7	biosimilars	biosimilar	NOUN
gs-4060	311	8	aim	aim	VERB
gs-4060	311	9	to	to	PART
gs-4060	311	10	address	address	VERB
gs-4060	311	11	this	this	DET
gs-4060	311	12	gap	gap	NOUN
gs-4060	311	13	.	.	PUNCT
gs-4060	312	1	emerging	emerge	VERB
gs-4060	312	2	approaches	approach	NOUN
gs-4060	312	3	also	also	ADV
gs-4060	312	4	focus	focus	VERB
gs-4060	312	5	on	on	ADP
gs-4060	312	6	targeting	target	VERB
gs-4060	312	7	cancer	cancer	NOUN
gs-4060	312	8	stem	stem	NOUN
gs-4060	312	9	cells	cell	NOUN
gs-4060	312	10	(	(	PUNCT
gs-4060	312	11	cscs	cscs	PROPN
gs-4060	312	12	)	)	PUNCT
gs-4060	312	13	via	via	ADP
gs-4060	312	14	pathways	pathway	NOUN
gs-4060	312	15	like	like	ADP
gs-4060	312	16	wnt	wnt	NOUN
gs-4060	312	17	and	and	CCONJ
gs-4060	312	18	hedgehog	hedgehog	PROPN
gs-4060	312	19	,	,	PUNCT
gs-4060	312	20	potentially	potentially	ADV
gs-4060	312	21	preventing	prevent	VERB
gs-4060	312	22	relapse	relapse	NOUN
gs-4060	312	23	.	.	PUNCT
gs-4060	313	1	nanotechnology	nanotechnology	PROPN
gs-4060	313	2	,	,	PUNCT
gs-4060	313	3	including	include	VERB
gs-4060	313	4	liposomes	liposome	NOUN
gs-4060	313	5	and	and	CCONJ
gs-4060	313	6	microneedles	microneedle	NOUN
gs-4060	313	7	,	,	PUNCT
gs-4060	313	8	improves	improve	VERB
gs-4060	313	9	drug	drug	NOUN
gs-4060	313	10	delivery	delivery	NOUN
gs-4060	313	11	,	,	PUNCT
gs-4060	313	12	enhancing	enhance	VERB
gs-4060	313	13	bioavailability	bioavailability	NOUN
gs-4060	313	14	and	and	CCONJ
gs-4060	313	15	reducing	reduce	VERB
gs-4060	313	16	off	off	ADP
gs-4060	313	17	-	-	PUNCT
gs-4060	313	18	target	target	NOUN
gs-4060	313	19	effects	effect	NOUN
gs-4060	313	20	.	.	PUNCT
gs-4060	314	1	ethical	ethical	ADJ
gs-4060	314	2	considerations	consideration	NOUN
gs-4060	314	3	,	,	PUNCT
gs-4060	314	4	such	such	ADJ
gs-4060	314	5	as	as	ADP
gs-4060	314	6	equitable	equitable	ADJ
gs-4060	314	7	access	access	NOUN
gs-4060	314	8	and	and	CCONJ
gs-4060	314	9	informed	informed	ADJ
gs-4060	314	10	consent	consent	NOUN
gs-4060	314	11	in	in	ADP
gs-4060	314	12	trials	trial	NOUN
gs-4060	314	13	,	,	PUNCT
gs-4060	314	14	are	be	AUX
gs-4060	314	15	paramount	paramount	ADJ
gs-4060	314	16	as	as	ADP
gs-4060	314	17	oncology	oncology	NOUN
gs-4060	314	18	advances	advance	NOUN
gs-4060	314	19	.	.	PUNCT
gs-4060	315	1	detailed	detailed	ADJ
gs-4060	315	2	analysis	analysis	NOUN
gs-4060	315	3	of	of	ADP
gs-4060	315	4	specific	specific	ADJ
gs-4060	315	5	drugs	drug	NOUN
gs-4060	315	6	tafasitamab	tafasitamab	NOUN
gs-4060	315	7	-	-	PUNCT
gs-4060	315	8	cxix	cxix	ADJ
gs-4060	315	9	(	(	PUNCT
gs-4060	315	10	monjuvi	monjuvi	NOUN
gs-4060	315	11	):	):	PUNCT
gs-4060	315	12	this	this	DET
gs-4060	315	13	bispecific	bispecific	NOUN
gs-4060	315	14	antibody	antibody	NOUN
gs-4060	315	15	targets	target	VERB
gs-4060	315	16	cd19	cd19	PROPN
gs-4060	315	17	and	and	CCONJ
gs-4060	315	18	cd3	cd3	VERB
gs-4060	315	19	,	,	PUNCT
gs-4060	315	20	promoting	promote	VERB
gs-4060	315	21	tcell	tcell	NOUN
gs-4060	315	22	-	-	PUNCT
gs-4060	315	23	mediated	mediate	VERB
gs-4060	315	24	lysis	lysis	NOUN
gs-4060	315	25	of	of	ADP
gs-4060	315	26	b	b	NOUN
gs-4060	315	27	-	-	PUNCT
gs-4060	315	28	cells	cell	NOUN
gs-4060	315	29	.	.	PUNCT
gs-4060	316	1	administered	administer	VERB
gs-4060	316	2	intravenously	intravenously	ADV
gs-4060	316	3	with	with	ADP
gs-4060	316	4	a	a	DET
gs-4060	316	5	half	half	ADJ
gs-4060	316	6	-	-	PUNCT
gs-4060	316	7	life	life	NOUN
gs-4060	316	8	of	of	ADP
gs-4060	316	9	approximately	approximately	ADV
gs-4060	316	10	17	17	NUM
gs-4060	316	11	days	day	NOUN
gs-4060	316	12	,	,	PUNCT
gs-4060	316	13	it	it	PRON
gs-4060	316	14	achieves	achieve	VERB
gs-4060	316	15	an	an	DET
gs-4060	316	16	orr	orr	NOUN
gs-4060	316	17	of	of	ADP
gs-4060	316	18	55	55	NUM
gs-4060	316	19	%	%	NOUN
gs-4060	316	20	in	in	ADP
gs-4060	316	21	relapsed	relapse	VERB
gs-4060	316	22	dlbcl	dlbcl	NOUN
gs-4060	316	23	.	.	PUNCT
gs-4060	317	1	toxicities	toxicity	NOUN
gs-4060	317	2	include	include	VERB
gs-4060	317	3	infusion	infusion	NOUN
gs-4060	317	4	-	-	PUNCT
gs-4060	317	5	related	relate	VERB
gs-4060	317	6	reactions	reaction	NOUN
gs-4060	317	7	and	and	CCONJ
gs-4060	317	8	cytopenias	cytopenia	NOUN
gs-4060	317	9	,	,	PUNCT
gs-4060	317	10	manageable	manageable	ADJ
gs-4060	317	11	with	with	ADP
gs-4060	317	12	premedication	premedication	NOUN
gs-4060	317	13	and	and	CCONJ
gs-4060	317	14	dose	dose	NOUN
gs-4060	317	15	adjustments	adjustment	NOUN
gs-4060	317	16	.	.	PUNCT
gs-4060	318	1	vimseltinib	vimseltinib	NOUN
gs-4060	318	2	(	(	PUNCT
gs-4060	318	3	romvimza	romvimza	ADV
gs-4060	318	4	):	):	PUNCT
gs-4060	318	5	a	a	DET
gs-4060	318	6	csf1r	csf1r	NOUN
gs-4060	318	7	inhibitor	inhibitor	NOUN
gs-4060	318	8	,	,	PUNCT
gs-4060	318	9	vimseltinib	vimseltinib	NOUN
gs-4060	318	10	is	be	AUX
gs-4060	318	11	orally	orally	ADV
gs-4060	318	12	administered	administer	VERB
gs-4060	318	13	once	once	ADV
gs-4060	318	14	daily	daily	ADV
gs-4060	318	15	,	,	PUNCT
gs-4060	318	16	achieving	achieve	VERB
gs-4060	318	17	tumor	tumor	NOUN
gs-4060	318	18	shrinkage	shrinkage	NOUN
gs-4060	318	19	in	in	ADP
gs-4060	318	20	70	70	NUM
gs-4060	318	21	%	%	NOUN
gs-4060	318	22	of	of	ADP
gs-4060	318	23	tenosynovial	tenosynovial	ADJ
gs-4060	318	24	giant	giant	ADJ
gs-4060	318	25	cell	cell	NOUN
gs-4060	318	26	tumor	tumor	NOUN
gs-4060	318	27	patients	patient	NOUN
gs-4060	318	28	.	.	PUNCT
gs-4060	319	1	common	common	ADJ
gs-4060	319	2	toxicities	toxicity	NOUN
gs-4060	319	3	include	include	VERB
gs-4060	319	4	edema	edema	NOUN
gs-4060	319	5	and	and	CCONJ
gs-4060	319	6	fatigue	fatigue	NOUN
gs-4060	319	7	,	,	PUNCT
gs-4060	319	8	with	with	ADP
gs-4060	319	9	low	low	ADJ
gs-4060	319	10	-	-	PUNCT
gs-4060	319	11	grade	grade	NOUN
gs-4060	319	12	severity	severity	NOUN
gs-4060	319	13	in	in	ADP
gs-4060	319	14	most	most	ADJ
gs-4060	319	15	cases	case	NOUN
gs-4060	319	16	.	.	PUNCT
gs-4060	320	1	mirdametinib	mirdametinib	ADJ
gs-4060	320	2	(	(	PUNCT
gs-4060	320	3	gomekli	gomekli	NOUN
gs-4060	320	4	):	):	PUNCT
gs-4060	320	5	this	this	DET
gs-4060	320	6	mek1/2	mek1/2	PROPN
gs-4060	320	7	inhibitor	inhibitor	NOUN
gs-4060	320	8	targets	target	VERB
gs-4060	320	9	the	the	DET
gs-4060	320	10	ras	ras	PROPN
gs-4060	320	11	/	/	SYM
gs-4060	320	12	mapk	mapk	NOUN
gs-4060	320	13	pathway	pathway	NOUN
gs-4060	320	14	in	in	ADP
gs-4060	320	15	neurofibromatosis	neurofibromatosis	NOUN
gs-4060	320	16	type	type	NOUN
gs-4060	320	17	1	1	NUM
gs-4060	320	18	.	.	PUNCT
gs-4060	321	1	it	it	PRON
gs-4060	321	2	improves	improve	VERB
gs-4060	321	3	symptoms	symptom	NOUN
gs-4060	321	4	in	in	ADP
gs-4060	321	5	plexiform	plexiform	NOUN
gs-4060	321	6	neurofibromas	neurofibroma	NOUN
gs-4060	321	7	,	,	PUNCT
gs-4060	321	8	with	with	ADP
gs-4060	321	9	toxicities	toxicity	NOUN
gs-4060	321	10	like	like	ADP
gs-4060	321	11	rash	rash	NOUN
gs-4060	321	12	and	and	CCONJ
gs-4060	321	13	diarrhea	diarrhea	NOUN
gs-4060	321	14	managed	manage	VERB
gs-4060	321	15	through	through	ADP
gs-4060	321	16	supportive	supportive	ADJ
gs-4060	321	17	care	care	NOUN
gs-4060	321	18	.	.	PUNCT
gs-4060	322	1	fam	fam	NOUN
gs-4060	322	2	-	-	PUNCT
gs-4060	322	3	trastuzumab	trastuzumab	NOUN
gs-4060	322	4	deruxtecan	deruxtecan	ADJ
gs-4060	322	5	-	-	PUNCT
gs-4060	322	6	nxki	nxki	ADJ
gs-4060	322	7	:	:	PUNCT
gs-4060	322	8	this	this	DET
gs-4060	322	9	adc	adc	PROPN
gs-4060	322	10	targets	target	NOUN
gs-4060	322	11	her2	her2	PROPN
gs-4060	322	12	,	,	PUNCT
gs-4060	322	13	delivering	deliver	VERB
gs-4060	322	14	a	a	DET
gs-4060	322	15	topoisomerase	topoisomerase	NOUN
gs-4060	322	16	i	i	PROPN
gs-4060	322	17	inhibitor	inhibitor	NOUN
gs-4060	322	18	payload	payload	NOUN
gs-4060	322	19	.	.	PUNCT
gs-4060	323	1	it	it	PRON
gs-4060	323	2	achieves	achieve	VERB
gs-4060	323	3	high	high	ADJ
gs-4060	323	4	orr	orr	PROPN
gs-4060	323	5	in	in	ADP
gs-4060	323	6	her2	her2	PROPN
gs-4060	323	7	-	-	PUNCT
gs-4060	323	8	positive	positive	ADJ
gs-4060	323	9	and	and	CCONJ
gs-4060	323	10	her2	her2	NOUN
gs-4060	323	11	-	-	PUNCT
gs-4060	323	12	low	low	ADJ
gs-4060	323	13	cancers	cancer	NOUN
gs-4060	323	14	but	but	CCONJ
gs-4060	323	15	carries	carry	VERB
gs-4060	323	16	risks	risk	NOUN
gs-4060	323	17	of	of	ADP
gs-4060	323	18	interstitial	interstitial	ADJ
gs-4060	323	19	lung	lung	NOUN
gs-4060	323	20	disease	disease	NOUN
gs-4060	323	21	,	,	PUNCT
gs-4060	323	22	requiring	require	VERB
gs-4060	323	23	vigilant	vigilant	ADJ
gs-4060	323	24	monitoring	monitoring	NOUN
gs-4060	323	25	.	.	PUNCT
gs-4060	324	1	pembrolizumab	pembrolizumab	NOUN
gs-4060	324	2	:	:	PUNCT
gs-4060	324	3	expanded	expand	VERB
gs-4060	324	4	for	for	ADP
gs-4060	324	5	gastric	gastric	NOUN
gs-4060	324	6	/	/	SYM
gs-4060	324	7	gej	gej	PROPN
gs-4060	324	8	adenocarcinoma	adenocarcinoma	NOUN
gs-4060	324	9	,	,	PUNCT
gs-4060	324	10	this	this	PRON
gs-4060	324	11	pd-1	pd-1	VERB
gs-4060	324	12	inhibitor	inhibitor	NOUN
gs-4060	324	13	enhances	enhance	VERB
gs-4060	324	14	t	t	NOUN
gs-4060	324	15	-	-	PUNCT
gs-4060	324	16	cell	cell	NOUN
gs-4060	324	17	responses	response	NOUN
gs-4060	324	18	,	,	PUNCT
gs-4060	324	19	with	with	ADP
gs-4060	324	20	durable	durable	ADJ
gs-4060	324	21	responses	response	NOUN
gs-4060	324	22	in	in	ADP
gs-4060	324	23	msi	msi	PROPN
gs-4060	324	24	-	-	PROPN
gs-4060	324	25	h	h	NOUN
gs-4060	324	26	tumors	tumor	NOUN
gs-4060	324	27	.	.	PUNCT
gs-4060	325	1	immune	immune	NOUN
gs-4060	325	2	-	-	PUNCT
gs-4060	325	3	related	relate	VERB
gs-4060	325	4	toxicities	toxicity	NOUN
gs-4060	325	5	,	,	PUNCT
gs-4060	325	6	such	such	ADJ
gs-4060	325	7	as	as	ADP
gs-4060	325	8	colitis	colitis	NOUN
gs-4060	325	9	,	,	PUNCT
gs-4060	325	10	are	be	AUX
gs-4060	325	11	managed	manage	VERB
gs-4060	325	12	with	with	ADP
gs-4060	325	13	corticosteroids	corticosteroid	NOUN
gs-4060	325	14	.	.	PUNCT
gs-4060	326	1	combination	combination	NOUN
gs-4060	326	2	therapies	therapy	NOUN
gs-4060	326	3	and	and	CCONJ
gs-4060	326	4	resistance	resistance	NOUN
gs-4060	326	5	combination	combination	NOUN
gs-4060	326	6	therapies	therapy	NOUN
gs-4060	326	7	enhance	enhance	VERB
gs-4060	326	8	efficacy	efficacy	NOUN
gs-4060	326	9	by	by	ADP
gs-4060	326	10	targeting	target	VERB
gs-4060	326	11	multiple	multiple	ADJ
gs-4060	326	12	pathways	pathway	NOUN
gs-4060	326	13	.	.	PUNCT
gs-4060	327	1	for	for	ADP
gs-4060	327	2	example	example	NOUN
gs-4060	327	3	,	,	PUNCT
gs-4060	327	4	encorafenib	encorafenib	NOUN
gs-4060	327	5	with	with	ADP
gs-4060	327	6	cetuximab	cetuximab	NOUN
gs-4060	327	7	and	and	CCONJ
gs-4060	327	8	mfolfox6	mfolfox6	NOUN
gs-4060	327	9	improves	improve	VERB
gs-4060	327	10	survival	survival	NOUN
gs-4060	327	11	in	in	ADP
gs-4060	327	12	braf	braf	NOUN
gs-4060	327	13	-	-	PUNCT
gs-4060	327	14	mutated	mutate	VERB
gs-4060	327	15	colorectal	colorectal	ADJ
gs-4060	327	16	cancer	cancer	NOUN
gs-4060	327	17	by	by	ADP
gs-4060	327	18	inhibiting	inhibit	VERB
gs-4060	327	19	mapk	mapk	NOUN
gs-4060	327	20	signaling	signal	VERB
gs-4060	327	21	and	and	CCONJ
gs-4060	327	22	enhancing	enhance	VERB
gs-4060	327	23	cytotoxic	cytotoxic	ADJ
gs-4060	327	24	effects	effect	NOUN
gs-4060	327	25	.	.	PUNCT
gs-4060	328	1	however	however	ADV
gs-4060	328	2	,	,	PUNCT
gs-4060	328	3	resistance	resistance	NOUN
gs-4060	328	4	mechanisms	mechanism	NOUN
gs-4060	328	5	,	,	PUNCT
gs-4060	328	6	such	such	ADJ
gs-4060	328	7	as	as	ADP
gs-4060	328	8	egfr	egfr	ADJ
gs-4060	328	9	t790	t790	NUM
gs-4060	328	10	m	m	NOUN
gs-4060	328	11	mutations	mutation	NOUN
gs-4060	328	12	in	in	ADP
gs-4060	328	13	nsclc	nsclc	NOUN
gs-4060	328	14	,	,	PUNCT
gs-4060	328	15	necessitate	necessitate	ADJ
gs-4060	328	16	next	next	ADJ
gs-4060	328	17	-	-	PUNCT
gs-4060	328	18	generation	generation	NOUN
gs-4060	328	19	tkis	tkis	NOUN
gs-4060	328	20	like	like	ADP
gs-4060	328	21	osimertinib	osimertinib	NOUN
gs-4060	328	22	.	.	PUNCT
gs-4060	329	1	tumor	tumor	NOUN
gs-4060	329	2	microenvironment	microenvironment	ADJ
gs-4060	329	3	factors	factor	NOUN
gs-4060	329	4	,	,	PUNCT
gs-4060	329	5	including	include	VERB
gs-4060	329	6	hypoxia	hypoxia	NOUN
gs-4060	329	7	and	and	CCONJ
gs-4060	329	8	stromal	stromal	ADJ
gs-4060	329	9	interactions	interaction	NOUN
gs-4060	329	10	,	,	PUNCT
gs-4060	329	11	further	far	ADV
gs-4060	329	12	contribute	contribute	VERB
gs-4060	329	13	to	to	ADP
gs-4060	329	14	resistance	resistance	NOUN
gs-4060	329	15	,	,	PUNCT
gs-4060	329	16	highlighting	highlight	VERB
gs-4060	329	17	the	the	DET
gs-4060	329	18	need	need	NOUN
gs-4060	329	19	for	for	ADP
gs-4060	329	20	integrated	integrate	VERB
gs-4060	329	21	approaches	approach	NOUN
gs-4060	329	22	.	.	PUNCT
gs-4060	330	1	future	future	ADJ
gs-4060	330	2	innovations	innovation	NOUN
gs-4060	330	3	ai	ai	AUX
gs-4060	330	4	-	-	PUNCT
gs-4060	330	5	driven	drive	VERB
gs-4060	330	6	drug	drug	NOUN
gs-4060	330	7	discovery	discovery	NOUN
gs-4060	330	8	accelerates	accelerate	VERB
gs-4060	330	9	target	target	NOUN
gs-4060	330	10	identification	identification	NOUN
gs-4060	330	11	and	and	CCONJ
gs-4060	330	12	optimizes	optimize	VERB
gs-4060	330	13	molecular	molecular	ADJ
gs-4060	330	14	design	design	NOUN
gs-4060	330	15	,	,	PUNCT
gs-4060	330	16	reducing	reduce	VERB
gs-4060	330	17	development	development	NOUN
gs-4060	330	18	timelines	timeline	NOUN
gs-4060	330	19	.	.	PUNCT
gs-4060	331	1	microbiome	microbiome	NOUN
gs-4060	331	2	-	-	PUNCT
gs-4060	331	3	based	base	VERB
gs-4060	331	4	interventions	intervention	NOUN
gs-4060	331	5	,	,	PUNCT
gs-4060	331	6	such	such	ADJ
gs-4060	331	7	as	as	ADP
gs-4060	331	8	probiotics	probiotic	NOUN
gs-4060	331	9	,	,	PUNCT
gs-4060	331	10	enhance	enhance	VERB
gs-4060	331	11	immunotherapy	immunotherapy	NOUN
gs-4060	331	12	outcomes	outcome	NOUN
gs-4060	331	13	by	by	ADP
gs-4060	331	14	modulating	modulate	VERB
gs-4060	331	15	immune	immune	ADJ
gs-4060	331	16	responses	response	NOUN
gs-4060	331	17	.	.	PUNCT
gs-4060	332	1	csc	csc	ADJ
gs-4060	332	2	-	-	PUNCT
gs-4060	332	3	targeted	target	VERB
gs-4060	332	4	therapies	therapy	NOUN
gs-4060	332	5	,	,	PUNCT
gs-4060	332	6	like	like	ADP
gs-4060	332	7	hedgehog	hedgehog	NOUN
gs-4060	332	8	inhibitors	inhibitor	NOUN
gs-4060	332	9	(	(	PUNCT
gs-4060	332	10	e.g.	e.g.	ADV
gs-4060	332	11	,	,	PUNCT
gs-4060	332	12	vismodegib	vismodegib	NOUN
gs-4060	332	13	)	)	PUNCT
gs-4060	332	14	,	,	PUNCT
gs-4060	332	15	aim	aim	VERB
gs-4060	332	16	to	to	PART
gs-4060	332	17	prevent	prevent	VERB
gs-4060	332	18	tumor	tumor	NOUN
gs-4060	332	19	recurrence	recurrence	NOUN
gs-4060	332	20	.	.	PUNCT
gs-4060	333	1	nanotechnology	nanotechnology	NOUN
gs-4060	333	2	advances	advance	NOUN
gs-4060	333	3	,	,	PUNCT
gs-4060	333	4	including	include	VERB
gs-4060	333	5	ph	ph	ADJ
gs-4060	333	6	-	-	ADJ
gs-4060	333	7	sensitive	sensitive	ADJ
gs-4060	333	8	nanoparticles	nanoparticle	NOUN
gs-4060	333	9	,	,	PUNCT
gs-4060	333	10	improve	improve	VERB
gs-4060	333	11	drug	drug	NOUN
gs-4060	333	12	delivery	delivery	NOUN
gs-4060	333	13	to	to	ADP
gs-4060	333	14	acidic	acidic	ADJ
gs-4060	333	15	tumor	tumor	NOUN
gs-4060	333	16	georgian	georgian	NOUN
gs-4060	333	17	scientists/	scientists/	NUM
gs-4060	333	18	.	.	PUNCT
gs-4060	334	1	7	7	NUM
gs-4060	334	2	n	n	PRON
gs-4060	334	3	3	3	NUM
gs-4060	334	4	,	,	PUNCT
gs-4060	334	5	2025	2025	NUM
gs-4060	334	6	585	585	NUM
gs-4060	334	7	microenvironments	microenvironment	NOUN
gs-4060	334	8	.	.	PUNCT
gs-4060	335	1	these	these	DET
gs-4060	335	2	innovations	innovation	NOUN
gs-4060	335	3	promise	promise	VERB
gs-4060	335	4	to	to	PART
gs-4060	335	5	address	address	VERB
gs-4060	335	6	resistance	resistance	NOUN
gs-4060	335	7	and	and	CCONJ
gs-4060	335	8	toxicity	toxicity	NOUN
gs-4060	335	9	while	while	SCONJ
gs-4060	335	10	improving	improve	VERB
gs-4060	335	11	global	global	ADJ
gs-4060	335	12	access	access	NOUN
gs-4060	335	13	through	through	ADP
gs-4060	335	14	cost	cost	NOUN
gs-4060	335	15	-	-	PUNCT
gs-4060	335	16	effective	effective	ADJ
gs-4060	335	17	solutions	solution	NOUN
gs-4060	335	18	like	like	ADP
gs-4060	335	19	repurposed	repurpose	VERB
gs-4060	335	20	drugs	drug	NOUN
gs-4060	335	21	and	and	CCONJ
gs-4060	335	22	biosimilars	biosimilar	NOUN
gs-4060	335	23	.	.	PUNCT
gs-4060	336	1	recent	recent	ADJ
gs-4060	336	2	fda	fda	PROPN
gs-4060	336	3	approvals	approval	NOUN
gs-4060	336	4	and	and	CCONJ
gs-4060	336	5	clinical	clinical	ADJ
gs-4060	336	6	data	datum	NOUN
gs-4060	336	7	underscore	underscore	VERB
gs-4060	336	8	the	the	DET
gs-4060	336	9	transformative	transformative	ADJ
gs-4060	336	10	potential	potential	NOUN
gs-4060	336	11	of	of	ADP
gs-4060	336	12	new	new	ADJ
gs-4060	336	13	anticancer	anticancer	NOUN
gs-4060	336	14	drugs	drug	NOUN
gs-4060	336	15	,	,	PUNCT
gs-4060	336	16	from	from	ADP
gs-4060	336	17	adcs	adcs	ADJ
gs-4060	336	18	and	and	CCONJ
gs-4060	336	19	tkis	tkis	NOUN
gs-4060	336	20	to	to	ADP
gs-4060	336	21	immunotherapies	immunotherapy	NOUN
gs-4060	336	22	and	and	CCONJ
gs-4060	336	23	natural	natural	ADJ
gs-4060	336	24	compounds	compound	NOUN
gs-4060	336	25	.	.	PUNCT
gs-4060	337	1	while	while	SCONJ
gs-4060	337	2	therapeutic	therapeutic	ADJ
gs-4060	337	3	effects	effect	NOUN
gs-4060	337	4	are	be	AUX
gs-4060	337	5	promising	promise	VERB
gs-4060	337	6	,	,	PUNCT
gs-4060	337	7	toxicities	toxicity	NOUN
gs-4060	337	8	and	and	CCONJ
gs-4060	337	9	resistance	resistance	NOUN
gs-4060	337	10	remain	remain	VERB
gs-4060	337	11	significant	significant	ADJ
gs-4060	337	12	hurdles	hurdle	NOUN
gs-4060	337	13	.	.	PUNCT
gs-4060	338	1	future	future	ADJ
gs-4060	338	2	directions	direction	NOUN
gs-4060	338	3	leveraging	leverage	VERB
gs-4060	338	4	ai	ai	VERB
gs-4060	338	5	,	,	PUNCT
gs-4060	338	6	microbiome	microbiome	ADJ
gs-4060	338	7	modulation	modulation	NOUN
gs-4060	338	8	,	,	PUNCT
gs-4060	338	9	and	and	CCONJ
gs-4060	338	10	advanced	advanced	ADJ
gs-4060	338	11	delivery	delivery	NOUN
gs-4060	338	12	systems	system	NOUN
gs-4060	338	13	offer	offer	VERB
gs-4060	338	14	hope	hope	NOUN
gs-4060	338	15	for	for	ADP
gs-4060	338	16	more	more	ADV
gs-4060	338	17	effective	effective	ADJ
gs-4060	338	18	,	,	PUNCT
gs-4060	338	19	accessible	accessible	ADJ
gs-4060	338	20	treatments	treatment	NOUN
gs-4060	338	21	.	.	PUNCT
gs-4060	339	1	integrated	integrate	VERB
gs-4060	339	2	strategies	strategy	NOUN
gs-4060	339	3	combining	combine	VERB
gs-4060	339	4	precision	precision	NOUN
gs-4060	339	5	medicine	medicine	NOUN
gs-4060	339	6	with	with	ADP
gs-4060	339	7	supportive	supportive	ADJ
gs-4060	339	8	care	care	NOUN
gs-4060	339	9	will	will	AUX
gs-4060	339	10	be	be	AUX
gs-4060	339	11	critical	critical	ADJ
gs-4060	339	12	to	to	ADP
gs-4060	339	13	optimizing	optimize	VERB
gs-4060	339	14	outcomes	outcome	NOUN
gs-4060	339	15	in	in	ADP
gs-4060	339	16	oncology	oncology	NOUN
gs-4060	339	17	.	.	PUNCT
gs-4060	340	1	classification	classification	NOUN
gs-4060	340	2	of	of	ADP
gs-4060	340	3	new	new	ADJ
gs-4060	340	4	anticancer	anticancer	NOUN
gs-4060	340	5	agents	agent	NOUN
gs-4060	340	6	the	the	DET
gs-4060	340	7	traditional	traditional	ADJ
gs-4060	340	8	classification	classification	NOUN
gs-4060	340	9	of	of	ADP
gs-4060	340	10	anticancer	anticancer	NOUN
gs-4060	340	11	drugs	drug	NOUN
gs-4060	340	12	based	base	VERB
gs-4060	340	13	on	on	ADP
gs-4060	340	14	their	their	PRON
gs-4060	340	15	origin	origin	NOUN
gs-4060	340	16	or	or	CCONJ
gs-4060	340	17	their	their	PRON
gs-4060	340	18	effect	effect	NOUN
gs-4060	340	19	on	on	ADP
gs-4060	340	20	the	the	DET
gs-4060	340	21	cell	cell	NOUN
gs-4060	340	22	cycle	cycle	NOUN
gs-4060	340	23	has	have	AUX
gs-4060	340	24	been	be	AUX
gs-4060	340	25	rendered	render	VERB
gs-4060	340	26	obsolete	obsolete	ADJ
gs-4060	340	27	by	by	ADP
gs-4060	340	28	the	the	DET
gs-4060	340	29	new	new	ADJ
gs-4060	340	30	generation	generation	NOUN
gs-4060	340	31	of	of	ADP
gs-4060	340	32	therapeutics	therapeutic	NOUN
gs-4060	340	33	.	.	PUNCT
gs-4060	341	1	a	a	DET
gs-4060	341	2	modern	modern	ADJ
gs-4060	341	3	,	,	PUNCT
gs-4060	341	4	scientifically	scientifically	ADV
gs-4060	341	5	coherent	coherent	ADJ
gs-4060	341	6	taxonomy	taxonomy	NOUN
gs-4060	341	7	must	must	AUX
gs-4060	341	8	be	be	AUX
gs-4060	341	9	rooted	root	VERB
gs-4060	341	10	in	in	ADP
gs-4060	341	11	the	the	DET
gs-4060	341	12	fundamental	fundamental	ADJ
gs-4060	341	13	mechanism	mechanism	NOUN
gs-4060	341	14	of	of	ADP
gs-4060	341	15	action	action	NOUN
gs-4060	341	16	and	and	CCONJ
gs-4060	341	17	the	the	DET
gs-4060	341	18	biological	biological	ADJ
gs-4060	341	19	target	target	NOUN
gs-4060	341	20	.	.	PUNCT
gs-4060	342	1	this	this	DET
gs-4060	342	2	framework	framework	NOUN
gs-4060	342	3	yields	yield	VERB
gs-4060	342	4	two	two	NUM
gs-4060	342	5	primary	primary	ADJ
gs-4060	342	6	,	,	PUNCT
gs-4060	342	7	overarching	overarching	ADJ
gs-4060	342	8	categories	category	NOUN
gs-4060	342	9	:	:	PUNCT
gs-4060	342	10	molecularly	molecularly	ADV
gs-4060	342	11	targeted	target	VERB
gs-4060	342	12	therapy	therapy	NOUN
gs-4060	342	13	and	and	CCONJ
gs-4060	342	14	cancer	cancer	NOUN
gs-4060	342	15	immunotherapy	immunotherapy	NOUN
gs-4060	342	16	,	,	PUNCT
gs-4060	342	17	each	each	PRON
gs-4060	342	18	encompassing	encompass	VERB
gs-4060	342	19	a	a	DET
gs-4060	342	20	diverse	diverse	ADJ
gs-4060	342	21	array	array	NOUN
gs-4060	342	22	of	of	ADP
gs-4060	342	23	drug	drug	NOUN
gs-4060	342	24	classes	class	NOUN
gs-4060	342	25	.	.	PUNCT
gs-4060	343	1	molecularly	molecularly	ADV
gs-4060	343	2	targeted	target	VERB
gs-4060	343	3	therapies	therapy	NOUN
gs-4060	343	4	are	be	AUX
gs-4060	343	5	agents	agent	NOUN
gs-4060	343	6	designed	design	VERB
gs-4060	343	7	to	to	PART
gs-4060	343	8	interfere	interfere	VERB
gs-4060	343	9	with	with	ADP
gs-4060	343	10	specific	specific	ADJ
gs-4060	343	11	molecules	molecule	NOUN
gs-4060	343	12	that	that	PRON
gs-4060	343	13	are	be	AUX
gs-4060	343	14	crucial	crucial	ADJ
gs-4060	343	15	for	for	ADP
gs-4060	343	16	tumor	tumor	NOUN
gs-4060	343	17	growth	growth	NOUN
gs-4060	343	18	,	,	PUNCT
gs-4060	343	19	progression	progression	NOUN
gs-4060	343	20	,	,	PUNCT
gs-4060	343	21	and	and	CCONJ
gs-4060	343	22	survival	survival	NOUN
gs-4060	343	23	.	.	PUNCT
gs-4060	344	1	this	this	DET
gs-4060	344	2	broad	broad	ADJ
gs-4060	344	3	category	category	NOUN
gs-4060	344	4	can	can	AUX
gs-4060	344	5	be	be	AUX
gs-4060	344	6	further	far	ADV
gs-4060	344	7	subdivided	subdivide	VERB
gs-4060	344	8	based	base	VERB
gs-4060	344	9	on	on	ADP
gs-4060	344	10	the	the	DET
gs-4060	344	11	nature	nature	NOUN
gs-4060	344	12	of	of	ADP
gs-4060	344	13	the	the	DET
gs-4060	344	14	agent	agent	NOUN
gs-4060	344	15	and	and	CCONJ
gs-4060	344	16	its	its	PRON
gs-4060	344	17	target	target	NOUN
gs-4060	344	18	.	.	PUNCT
gs-4060	345	1	small	small	ADJ
gs-4060	345	2	molecule	molecule	NOUN
gs-4060	345	3	inhibitors	inhibitor	NOUN
gs-4060	345	4	are	be	AUX
gs-4060	345	5	typically	typically	ADV
gs-4060	345	6	orally	orally	ADV
gs-4060	345	7	bioavailable	bioavailable	ADJ
gs-4060	345	8	compounds	compound	NOUN
gs-4060	345	9	that	that	PRON
gs-4060	345	10	penetrate	penetrate	VERB
gs-4060	345	11	the	the	DET
gs-4060	345	12	cell	cell	NOUN
gs-4060	345	13	membrane	membrane	NOUN
gs-4060	345	14	to	to	PART
gs-4060	345	15	bind	bind	VERB
gs-4060	345	16	to	to	ADP
gs-4060	345	17	specific	specific	ADJ
gs-4060	345	18	intracellular	intracellular	ADJ
gs-4060	345	19	targets	target	NOUN
gs-4060	345	20	,	,	PUNCT
gs-4060	345	21	most	most	ADV
gs-4060	345	22	commonly	commonly	ADV
gs-4060	345	23	the	the	DET
gs-4060	345	24	adenosine	adenosine	NOUN
gs-4060	345	25	triphosphate	triphosphate	NOUN
gs-4060	345	26	(	(	PUNCT
gs-4060	345	27	atp)-binding	atp)-binding	NOUN
gs-4060	345	28	site	site	NOUN
gs-4060	345	29	of	of	ADP
gs-4060	345	30	enzyme	enzyme	NOUN
gs-4060	345	31	domains	domain	NOUN
gs-4060	345	32	.	.	PUNCT
gs-4060	346	1	a	a	DET
gs-4060	346	2	paramount	paramount	ADJ
gs-4060	346	3	example	example	NOUN
gs-4060	346	4	is	be	AUX
gs-4060	346	5	the	the	DET
gs-4060	346	6	class	class	NOUN
gs-4060	346	7	of	of	ADP
gs-4060	346	8	tyrosine	tyrosine	NOUN
gs-4060	346	9	kinase	kinase	PROPN
gs-4060	346	10	inhibitors	inhibitor	NOUN
gs-4060	346	11	,	,	PUNCT
gs-4060	346	12	which	which	PRON
gs-4060	346	13	block	block	VERB
gs-4060	346	14	the	the	DET
gs-4060	346	15	aberrant	aberrant	NOUN
gs-4060	346	16	signaling	signaling	NOUN
gs-4060	346	17	of	of	ADP
gs-4060	346	18	growth	growth	NOUN
gs-4060	346	19	factor	factor	NOUN
gs-4060	346	20	receptors	receptor	NOUN
gs-4060	346	21	such	such	ADJ
gs-4060	346	22	as	as	ADP
gs-4060	346	23	the	the	DET
gs-4060	346	24	epidermal	epidermal	ADJ
gs-4060	346	25	growth	growth	NOUN
gs-4060	346	26	factor	factor	NOUN
gs-4060	346	27	receptor	receptor	NOUN
gs-4060	346	28	,	,	PUNCT
gs-4060	346	29	the	the	DET
gs-4060	346	30	breakpoint	breakpoint	PROPN
gs-4060	346	31	cluster	cluster	NOUN
gs-4060	346	32	regionabelson	regionabelson	PROPN
gs-4060	346	33	kinase	kinase	PROPN
gs-4060	346	34	,	,	PUNCT
gs-4060	346	35	and	and	CCONJ
gs-4060	346	36	the	the	DET
gs-4060	346	37	anaplastic	anaplastic	ADJ
gs-4060	346	38	lymphoma	lymphoma	NOUN
gs-4060	346	39	kinase	kinase	NOUN
gs-4060	346	40	,	,	PUNCT
gs-4060	346	41	among	among	ADP
gs-4060	346	42	many	many	ADJ
gs-4060	346	43	others	other	NOUN
gs-4060	346	44	.	.	PUNCT
gs-4060	347	1	other	other	ADJ
gs-4060	347	2	critical	critical	ADJ
gs-4060	347	3	intracellular	intracellular	ADJ
gs-4060	347	4	targets	target	NOUN
gs-4060	347	5	include	include	VERB
gs-4060	347	6	kinases	kinase	NOUN
gs-4060	347	7	in	in	ADP
gs-4060	347	8	the	the	DET
gs-4060	347	9	mitogen	mitogen	NOUN
gs-4060	347	10	-	-	PUNCT
gs-4060	347	11	activated	activate	VERB
gs-4060	347	12	protein	protein	NOUN
gs-4060	347	13	kinase	kinase	NOUN
gs-4060	347	14	pathway	pathway	NOUN
gs-4060	347	15	and	and	CCONJ
gs-4060	347	16	the	the	DET
gs-4060	347	17	phosphoinositide	phosphoinositide	ADJ
gs-4060	347	18	3	3	NUM
gs-4060	347	19	-	-	PUNCT
gs-4060	347	20	kinase	kinase	NOUN
gs-4060	347	21	pathway	pathway	NOUN
gs-4060	347	22	,	,	PUNCT
gs-4060	347	23	as	as	ADV
gs-4060	347	24	well	well	ADV
gs-4060	347	25	as	as	ADP
gs-4060	347	26	proteins	protein	NOUN
gs-4060	347	27	involved	involve	VERB
gs-4060	347	28	in	in	ADP
gs-4060	347	29	cell	cell	NOUN
gs-4060	347	30	cycle	cycle	NOUN
gs-4060	347	31	regulation	regulation	NOUN
gs-4060	347	32	like	like	ADP
gs-4060	347	33	cyclindependent	cyclindependent	NOUN
gs-4060	347	34	kinases	kinase	NOUN
gs-4060	347	35	.	.	PUNCT
gs-4060	348	1	another	another	DET
gs-4060	348	2	major	major	ADJ
gs-4060	348	3	subclass	subclass	NOUN
gs-4060	348	4	within	within	ADP
gs-4060	348	5	targeted	target	VERB
gs-4060	348	6	therapy	therapy	NOUN
gs-4060	348	7	is	be	AUX
gs-4060	348	8	monoclonal	monoclonal	NOUN
gs-4060	348	9	antibodies	antibody	NOUN
gs-4060	348	10	.	.	PUNCT
gs-4060	349	1	these	these	PRON
gs-4060	349	2	are	be	AUX
gs-4060	349	3	large	large	ADJ
gs-4060	349	4	,	,	PUNCT
gs-4060	349	5	biologic	biologic	NOUN
gs-4060	349	6	agents	agent	NOUN
gs-4060	349	7	administered	administer	VERB
gs-4060	349	8	intravenously	intravenously	ADV
gs-4060	349	9	or	or	CCONJ
gs-4060	349	10	subcutaneously	subcutaneously	ADV
gs-4060	349	11	that	that	PRON
gs-4060	349	12	are	be	AUX
gs-4060	349	13	exquisitely	exquisitely	ADV
gs-4060	349	14	specific	specific	ADJ
gs-4060	349	15	for	for	ADP
gs-4060	349	16	extracellular	extracellular	ADJ
gs-4060	349	17	targets	target	NOUN
gs-4060	349	18	.	.	PUNCT
gs-4060	350	1	they	they	PRON
gs-4060	350	2	function	function	VERB
gs-4060	350	3	through	through	ADP
gs-4060	350	4	several	several	ADJ
gs-4060	350	5	mechanisms	mechanism	NOUN
gs-4060	350	6	,	,	PUNCT
gs-4060	350	7	including	include	VERB
gs-4060	350	8	blocking	block	VERB
gs-4060	350	9	ligandreceptor	ligandreceptor	NOUN
gs-4060	350	10	interactions	interaction	NOUN
gs-4060	350	11	,	,	PUNCT
gs-4060	350	12	delivering	deliver	VERB
gs-4060	350	13	cytotoxic	cytotoxic	ADJ
gs-4060	350	14	payloads	payload	NOUN
gs-4060	350	15	as	as	ADP
gs-4060	350	16	antibody	antibody	NOUN
gs-4060	350	17	-	-	PUNCT
gs-4060	350	18	drug	drug	NOUN
gs-4060	350	19	conjugates	conjugate	NOUN
gs-4060	350	20	,	,	PUNCT
gs-4060	350	21	or	or	CCONJ
gs-4060	350	22	recruiting	recruit	VERB
gs-4060	350	23	immune	immune	ADJ
gs-4060	350	24	effector	effector	NOUN
gs-4060	350	25	cells	cell	NOUN
gs-4060	350	26	to	to	PART
gs-4060	350	27	mediate	mediate	VERB
gs-4060	350	28	antibody	antibody	NOUN
gs-4060	350	29	-	-	PUNCT
gs-4060	350	30	dependent	dependent	ADJ
gs-4060	350	31	cellular	cellular	ADJ
gs-4060	350	32	cytotoxicity	cytotoxicity	NOUN
gs-4060	350	33	.	.	PUNCT
gs-4060	351	1	a	a	DET
gs-4060	351	2	third	third	ADJ
gs-4060	351	3	,	,	PUNCT
gs-4060	351	4	increasingly	increasingly	ADV
gs-4060	351	5	important	important	ADJ
gs-4060	351	6	subclass	subclass	NOUN
gs-4060	351	7	is	be	AUX
gs-4060	351	8	a	a	DET
gs-4060	351	9	group	group	NOUN
gs-4060	351	10	of	of	ADP
gs-4060	351	11	drugs	drug	NOUN
gs-4060	351	12	targeting	target	VERB
gs-4060	351	13	the	the	DET
gs-4060	351	14	dna	dna	PROPN
gs-4060	351	15	damage	damage	NOUN
gs-4060	351	16	response	response	NOUN
gs-4060	351	17	pathway	pathway	NOUN
gs-4060	351	18	,	,	PUNCT
gs-4060	351	19	most	most	ADV
gs-4060	351	20	notably	notably	ADV
gs-4060	351	21	poly	poly	ADJ
gs-4060	351	22	(	(	PUNCT
gs-4060	351	23	adp	adp	PROPN
gs-4060	351	24	-	-	PUNCT
gs-4060	351	25	ribose	ribose	NOUN
gs-4060	351	26	)	)	PUNCT
gs-4060	351	27	polymerase	polymerase	NOUN
gs-4060	351	28	inhibitors	inhibitor	NOUN
gs-4060	351	29	,	,	PUNCT
gs-4060	351	30	which	which	PRON
gs-4060	351	31	exploit	exploit	VERB
gs-4060	351	32	a	a	DET
gs-4060	351	33	synthetic	synthetic	ADJ
gs-4060	351	34	lethal	lethal	ADJ
gs-4060	351	35	relationship	relationship	NOUN
gs-4060	351	36	in	in	ADP
gs-4060	351	37	cancers	cancer	NOUN
gs-4060	351	38	with	with	ADP
gs-4060	351	39	homologous	homologous	ADJ
gs-4060	351	40	recombination	recombination	NOUN
gs-4060	351	41	deficiencies	deficiency	NOUN
gs-4060	351	42	,	,	PUNCT
gs-4060	351	43	such	such	ADJ
gs-4060	351	44	as	as	ADP
gs-4060	351	45	those	those	PRON
gs-4060	351	46	harboring	harbor	VERB
gs-4060	351	47	brca	brca	PROPN
gs-4060	351	48	mutations	mutation	NOUN
gs-4060	351	49	.	.	PUNCT
gs-4060	352	1	cancer	cancer	NOUN
gs-4060	352	2	immunotherapy	immunotherapy	NOUN
gs-4060	352	3	,	,	PUNCT
gs-4060	352	4	the	the	DET
gs-4060	352	5	second	second	ADJ
gs-4060	352	6	major	major	ADJ
gs-4060	352	7	category	category	NOUN
gs-4060	352	8	,	,	PUNCT
gs-4060	352	9	represents	represent	VERB
gs-4060	352	10	a	a	DET
gs-4060	352	11	conceptual	conceptual	ADJ
gs-4060	352	12	revolution	revolution	NOUN
gs-4060	352	13	rather	rather	ADV
gs-4060	352	14	than	than	ADP
gs-4060	352	15	a	a	DET
gs-4060	352	16	mere	mere	ADJ
gs-4060	352	17	incremental	incremental	ADJ
gs-4060	352	18	advance	advance	NOUN
gs-4060	352	19	.	.	PUNCT
gs-4060	353	1	these	these	DET
gs-4060	353	2	agents	agent	NOUN
gs-4060	353	3	do	do	AUX
gs-4060	353	4	not	not	PART
gs-4060	353	5	directly	directly	ADV
gs-4060	353	6	attack	attack	VERB
gs-4060	353	7	the	the	DET
gs-4060	353	8	tumor	tumor	NOUN
gs-4060	353	9	cell	cell	NOUN
gs-4060	353	10	but	but	CCONJ
gs-4060	353	11	instead	instead	ADV
gs-4060	353	12	potentiate	potentiate	VERB
gs-4060	353	13	the	the	DET
gs-4060	353	14	patient	patient	NOUN
gs-4060	353	15	's	's	PART
gs-4060	353	16	own	own	ADJ
gs-4060	353	17	immune	immune	ADJ
gs-4060	353	18	system	system	NOUN
gs-4060	353	19	to	to	PART
gs-4060	353	20	recognize	recognize	VERB
gs-4060	353	21	and	and	CCONJ
gs-4060	353	22	eliminate	eliminate	VERB
gs-4060	353	23	cancer	cancer	NOUN
gs-4060	353	24	.	.	PUNCT
gs-4060	354	1	the	the	DET
gs-4060	354	2	most	most	ADV
gs-4060	354	3	clinically	clinically	ADV
gs-4060	354	4	impactful	impactful	ADJ
gs-4060	354	5	class	class	NOUN
gs-4060	354	6	to	to	ADP
gs-4060	354	7	date	date	NOUN
gs-4060	354	8	is	be	AUX
gs-4060	354	9	the	the	DET
gs-4060	354	10	immune	immune	ADJ
gs-4060	354	11	checkpoint	checkpoint	NOUN
gs-4060	354	12	inhibitors	inhibitor	NOUN
gs-4060	354	13	.	.	PUNCT
gs-4060	355	1	these	these	PRON
gs-4060	355	2	are	be	AUX
gs-4060	355	3	monoclonal	monoclonal	NOUN
gs-4060	355	4	antibodies	antibody	NOUN
gs-4060	355	5	that	that	PRON
gs-4060	355	6	block	block	VERB
gs-4060	355	7	inhibitory	inhibitory	ADJ
gs-4060	355	8	receptors	receptor	NOUN
gs-4060	355	9	on	on	ADP
gs-4060	355	10	t	t	NOUN
gs-4060	355	11	-	-	PUNCT
gs-4060	355	12	cells	cell	NOUN
gs-4060	355	13	,	,	PUNCT
gs-4060	355	14	such	such	ADJ
gs-4060	355	15	as	as	ADP
gs-4060	355	16	programmed	program	VERB
gs-4060	355	17	death-1	death-1	NUM
gs-4060	355	18	and	and	CCONJ
gs-4060	355	19	cytotoxic	cytotoxic	ADJ
gs-4060	355	20	tlymphocyte	tlymphocyte	NOUN
gs-4060	355	21	-	-	PUNCT
gs-4060	355	22	associated	associate	VERB
gs-4060	355	23	protein	protein	NOUN
gs-4060	355	24	4	4	NUM
gs-4060	355	25	,	,	PUNCT
gs-4060	355	26	or	or	CCONJ
gs-4060	355	27	their	their	PRON
gs-4060	355	28	corresponding	corresponding	ADJ
gs-4060	355	29	ligands	ligand	NOUN
gs-4060	355	30	on	on	ADP
gs-4060	355	31	tumor	tumor	NOUN
gs-4060	355	32	and	and	CCONJ
gs-4060	355	33	immune	immune	ADJ
gs-4060	355	34	cells	cell	NOUN
gs-4060	355	35	,	,	PUNCT
gs-4060	355	36	such	such	ADJ
gs-4060	355	37	as	as	ADP
gs-4060	355	38	programmed	program	VERB
gs-4060	355	39	death	death	NOUN
gs-4060	355	40	-	-	PUNCT
gs-4060	355	41	ligand	ligand	NOUN
gs-4060	355	42	1	1	NUM
gs-4060	355	43	.	.	PUNCT
gs-4060	355	44	by	by	ADP
gs-4060	355	45	disrupting	disrupt	VERB
gs-4060	355	46	these	these	DET
gs-4060	355	47	"	"	PUNCT
gs-4060	355	48	brakes	brake	NOUN
gs-4060	355	49	"	"	PUNCT
gs-4060	355	50	on	on	ADP
gs-4060	355	51	the	the	DET
gs-4060	355	52	immune	immune	ADJ
gs-4060	355	53	system	system	NOUN
gs-4060	355	54	,	,	PUNCT
gs-4060	355	55	these	these	DET
gs-4060	355	56	agents	agent	NOUN
gs-4060	355	57	can	can	AUX
gs-4060	355	58	reinvigorate	reinvigorate	VERB
gs-4060	355	59	a	a	DET
gs-4060	355	60	pre	pre	ADJ
gs-4060	355	61	-	-	ADJ
gs-4060	355	62	existing	exist	VERB
gs-4060	355	63	but	but	CCONJ
gs-4060	355	64	suppressed	suppress	VERB
gs-4060	355	65	anti	anti	ADJ
gs-4060	355	66	-	-	ADJ
gs-4060	355	67	tumor	tumor	ADJ
gs-4060	355	68	t	t	NOUN
gs-4060	355	69	-	-	PUNCT
gs-4060	355	70	cell	cell	NOUN
gs-4060	355	71	response	response	NOUN
gs-4060	355	72	.	.	PUNCT
gs-4060	356	1	another	another	DET
gs-4060	356	2	transformative	transformative	ADJ
gs-4060	356	3	modality	modality	NOUN
gs-4060	356	4	is	be	AUX
gs-4060	356	5	adoptive	adoptive	ADJ
gs-4060	356	6	cell	cell	NOUN
gs-4060	356	7	transfer	transfer	NOUN
gs-4060	356	8	,	,	PUNCT
gs-4060	356	9	most	most	ADV
gs-4060	356	10	notably	notably	ADV
gs-4060	356	11	chimeric	chimeric	ADJ
gs-4060	356	12	antigen	antigen	ADJ
gs-4060	356	13	receptor	receptor	NOUN
gs-4060	356	14	t	t	NOUN
gs-4060	356	15	-	-	PUNCT
gs-4060	356	16	cell	cell	NOUN
gs-4060	356	17	therapy	therapy	NOUN
gs-4060	356	18	.	.	PUNCT
gs-4060	357	1	this	this	DET
gs-4060	357	2	highly	highly	ADV
gs-4060	357	3	personalized	personalize	VERB
gs-4060	357	4	approach	approach	NOUN
gs-4060	357	5	involves	involve	VERB
gs-4060	357	6	genetically	genetically	ADV
gs-4060	357	7	engineering	engineer	VERB
gs-4060	357	8	a	a	DET
gs-4060	357	9	patient	patient	NOUN
gs-4060	357	10	's	's	PART
gs-4060	357	11	t	t	NOUN
gs-4060	357	12	-	-	PUNCT
gs-4060	357	13	cells	cell	NOUN
gs-4060	357	14	to	to	PART
gs-4060	357	15	express	express	VERB
gs-4060	357	16	a	a	DET
gs-4060	357	17	receptor	receptor	NOUN
gs-4060	357	18	that	that	PRON
gs-4060	357	19	recognizes	recognize	VERB
gs-4060	357	20	a	a	DET
gs-4060	357	21	specific	specific	ADJ
gs-4060	357	22	tumor	tumor	NOUN
gs-4060	357	23	-	-	PUNCT
gs-4060	357	24	associated	associate	VERB
gs-4060	357	25	antigen	antigen	NOUN
gs-4060	357	26	,	,	PUNCT
gs-4060	357	27	thereby	thereby	ADV
gs-4060	357	28	generating	generate	VERB
gs-4060	357	29	a	a	DET
gs-4060	357	30	powerful	powerful	ADJ
gs-4060	357	31	,	,	PUNCT
gs-4060	357	32	living	live	VERB
gs-4060	357	33	georgian	georgian	NOUN
gs-4060	357	34	scientists/	scientists/	NUM
gs-4060	357	35	.	.	PUNCT
gs-4060	358	1	7	7	NUM
gs-4060	358	2	n	n	PRON
gs-4060	358	3	3	3	NUM
gs-4060	358	4	,	,	PUNCT
gs-4060	358	5	2025	2025	NUM
gs-4060	358	6	586	586	NUM
gs-4060	358	7	drug	drug	NOUN
gs-4060	358	8	capable	capable	ADJ
gs-4060	358	9	of	of	ADP
gs-4060	358	10	profound	profound	ADJ
gs-4060	358	11	antitumor	antitumor	PROPN
gs-4060	358	12	activity	activity	NOUN
gs-4060	358	13	.	.	PUNCT
gs-4060	359	1	further	further	ADJ
gs-4060	359	2	immunotherapeutic	immunotherapeutic	ADJ
gs-4060	359	3	strategies	strategy	NOUN
gs-4060	359	4	include	include	VERB
gs-4060	359	5	cancer	cancer	NOUN
gs-4060	359	6	vaccines	vaccine	NOUN
gs-4060	359	7	,	,	PUNCT
gs-4060	359	8	designed	design	VERB
gs-4060	359	9	to	to	PART
gs-4060	359	10	prime	prime	VERB
gs-4060	359	11	an	an	DET
gs-4060	359	12	immune	immune	ADJ
gs-4060	359	13	response	response	NOUN
gs-4060	359	14	against	against	ADP
gs-4060	359	15	tumor	tumor	NOUN
gs-4060	359	16	-	-	PUNCT
gs-4060	359	17	specific	specific	ADJ
gs-4060	359	18	antigens	antigen	NOUN
gs-4060	359	19	,	,	PUNCT
gs-4060	359	20	and	and	CCONJ
gs-4060	359	21	oncolytic	oncolytic	ADJ
gs-4060	359	22	viruses	virus	NOUN
gs-4060	359	23	,	,	PUNCT
gs-4060	359	24	which	which	PRON
gs-4060	359	25	selectively	selectively	ADV
gs-4060	359	26	infect	infect	VERB
gs-4060	359	27	and	and	CCONJ
gs-4060	359	28	lyse	lyse	NOUN
gs-4060	359	29	tumor	tumor	NOUN
gs-4060	359	30	cells	cell	NOUN
gs-4060	359	31	while	while	SCONJ
gs-4060	359	32	simultaneously	simultaneously	ADV
gs-4060	359	33	stimulating	stimulate	VERB
gs-4060	359	34	an	an	DET
gs-4060	359	35	immune	immune	ADJ
gs-4060	359	36	response	response	NOUN
gs-4060	359	37	within	within	ADP
gs-4060	359	38	the	the	DET
gs-4060	359	39	tumor	tumor	NOUN
gs-4060	359	40	microenvironment	microenvironment	NOUN
gs-4060	359	41	.	.	PUNCT
gs-4060	360	1	mechanisms	mechanism	NOUN
gs-4060	360	2	of	of	ADP
gs-4060	360	3	action	action	NOUN
gs-4060	360	4	:	:	PUNCT
gs-4060	360	5	a	a	DET
gs-4060	360	6	molecular	molecular	ADJ
gs-4060	360	7	perspective	perspective	NOUN
gs-4060	360	8	the	the	DET
gs-4060	360	9	mechanistic	mechanistic	ADJ
gs-4060	360	10	basis	basis	NOUN
gs-4060	360	11	for	for	ADP
gs-4060	360	12	these	these	DET
gs-4060	360	13	new	new	ADJ
gs-4060	360	14	drug	drug	NOUN
gs-4060	360	15	classes	class	NOUN
gs-4060	360	16	is	be	AUX
gs-4060	360	17	both	both	CCONJ
gs-4060	360	18	intricate	intricate	ADJ
gs-4060	360	19	and	and	CCONJ
gs-4060	360	20	elegant	elegant	ADJ
gs-4060	360	21	,	,	PUNCT
gs-4060	360	22	reflecting	reflect	VERB
gs-4060	360	23	a	a	DET
gs-4060	360	24	deep	deep	ADJ
gs-4060	360	25	understanding	understanding	NOUN
gs-4060	360	26	of	of	ADP
gs-4060	360	27	oncogenic	oncogenic	ADJ
gs-4060	360	28	signaling	signaling	NOUN
gs-4060	360	29	.	.	PUNCT
gs-4060	361	1	targeted	target	VERB
gs-4060	361	2	small	small	ADJ
gs-4060	361	3	molecule	molecule	NOUN
gs-4060	361	4	inhibitors	inhibitor	NOUN
gs-4060	361	5	achieve	achieve	VERB
gs-4060	361	6	their	their	PRON
gs-4060	361	7	effect	effect	NOUN
gs-4060	361	8	through	through	ADP
gs-4060	361	9	competitive	competitive	ADJ
gs-4060	361	10	or	or	CCONJ
gs-4060	361	11	allosteric	allosteric	ADJ
gs-4060	361	12	inhibition	inhibition	NOUN
gs-4060	361	13	of	of	ADP
gs-4060	361	14	enzymatic	enzymatic	ADJ
gs-4060	361	15	activity	activity	NOUN
gs-4060	361	16	.	.	PUNCT
gs-4060	362	1	for	for	ADP
gs-4060	362	2	instance	instance	NOUN
gs-4060	362	3	,	,	PUNCT
gs-4060	362	4	tyrosine	tyrosine	NOUN
gs-4060	362	5	kinase	kinase	PROPN
gs-4060	362	6	inhibitors	inhibitor	NOUN
gs-4060	362	7	bind	bind	VERB
gs-4060	362	8	to	to	ADP
gs-4060	362	9	the	the	DET
gs-4060	362	10	atp	atp	NOUN
gs-4060	362	11	-	-	PUNCT
gs-4060	362	12	binding	bind	VERB
gs-4060	362	13	pocket	pocket	NOUN
gs-4060	362	14	of	of	ADP
gs-4060	362	15	hyperactive	hyperactive	ADJ
gs-4060	362	16	kinases	kinase	NOUN
gs-4060	362	17	,	,	PUNCT
gs-4060	362	18	preventing	prevent	VERB
gs-4060	362	19	the	the	DET
gs-4060	362	20	phosphorylation	phosphorylation	NOUN
gs-4060	362	21	and	and	CCONJ
gs-4060	362	22	subsequent	subsequent	ADJ
gs-4060	362	23	activation	activation	NOUN
gs-4060	362	24	of	of	ADP
gs-4060	362	25	downstream	downstream	ADJ
gs-4060	362	26	proteins	protein	NOUN
gs-4060	362	27	in	in	ADP
gs-4060	362	28	critical	critical	ADJ
gs-4060	362	29	proliferative	proliferative	ADJ
gs-4060	362	30	and	and	CCONJ
gs-4060	362	31	anti	anti	ADJ
gs-4060	362	32	-	-	ADJ
gs-4060	362	33	apoptotic	apoptotic	ADJ
gs-4060	362	34	pathways	pathway	NOUN
gs-4060	362	35	.	.	PUNCT
gs-4060	363	1	this	this	DET
gs-4060	363	2	interruption	interruption	NOUN
gs-4060	363	3	in	in	ADP
gs-4060	363	4	signal	signal	ADJ
gs-4060	363	5	transduction	transduction	NOUN
gs-4060	363	6	cascades	cascade	NOUN
gs-4060	363	7	leads	lead	VERB
gs-4060	363	8	to	to	ADP
gs-4060	363	9	cell	cell	NOUN
gs-4060	363	10	cycle	cycle	NOUN
gs-4060	363	11	arrest	arrest	NOUN
gs-4060	363	12	,	,	PUNCT
gs-4060	363	13	induction	induction	NOUN
gs-4060	363	14	of	of	ADP
gs-4060	363	15	apoptosis	apoptosis	NOUN
gs-4060	363	16	,	,	PUNCT
gs-4060	363	17	and	and	CCONJ
gs-4060	363	18	inhibition	inhibition	NOUN
gs-4060	363	19	of	of	ADP
gs-4060	363	20	angiogenesis	angiogenesis	NOUN
gs-4060	363	21	.	.	PUNCT
gs-4060	364	1	the	the	DET
gs-4060	364	2	mechanism	mechanism	NOUN
gs-4060	364	3	of	of	ADP
gs-4060	364	4	monoclonal	monoclonal	NOUN
gs-4060	364	5	antibodies	antibody	NOUN
gs-4060	364	6	is	be	AUX
gs-4060	364	7	more	more	ADV
gs-4060	364	8	multifaceted	multifaceted	ADJ
gs-4060	364	9	.	.	PUNCT
gs-4060	365	1	naked	naked	ADJ
gs-4060	365	2	monoclonal	monoclonal	NOUN
gs-4060	365	3	antibodies	antibody	NOUN
gs-4060	365	4	can	can	AUX
gs-4060	365	5	simply	simply	ADV
gs-4060	365	6	act	act	VERB
gs-4060	365	7	as	as	ADP
gs-4060	365	8	receptor	receptor	NOUN
gs-4060	365	9	antagonists	antagonist	NOUN
gs-4060	365	10	,	,	PUNCT
gs-4060	365	11	sterically	sterically	ADV
gs-4060	365	12	hindering	hinder	VERB
gs-4060	365	13	a	a	DET
gs-4060	365	14	growth	growth	NOUN
gs-4060	365	15	factor	factor	NOUN
gs-4060	365	16	from	from	ADP
gs-4060	365	17	binding	bind	VERB
gs-4060	365	18	to	to	ADP
gs-4060	365	19	its	its	PRON
gs-4060	365	20	receptor	receptor	NOUN
gs-4060	365	21	and	and	CCONJ
gs-4060	365	22	initiating	initiate	VERB
gs-4060	365	23	downstream	downstream	ADJ
gs-4060	365	24	signaling	signaling	NOUN
gs-4060	365	25	.	.	PUNCT
gs-4060	366	1	alternatively	alternatively	ADV
gs-4060	366	2	,	,	PUNCT
gs-4060	366	3	they	they	PRON
gs-4060	366	4	can	can	AUX
gs-4060	366	5	cause	cause	VERB
gs-4060	366	6	receptor	receptor	NOUN
gs-4060	366	7	internalization	internalization	NOUN
gs-4060	366	8	and	and	CCONJ
gs-4060	366	9	degradation	degradation	NOUN
gs-4060	366	10	,	,	PUNCT
gs-4060	366	11	effectively	effectively	ADV
gs-4060	366	12	downregulating	downregulate	VERB
gs-4060	366	13	the	the	DET
gs-4060	366	14	target	target	NOUN
gs-4060	366	15	from	from	ADP
gs-4060	366	16	the	the	DET
gs-4060	366	17	cell	cell	NOUN
gs-4060	366	18	surface	surface	NOUN
gs-4060	366	19	.	.	PUNCT
gs-4060	367	1	furthermore	furthermore	ADV
gs-4060	367	2	,	,	PUNCT
gs-4060	367	3	the	the	DET
gs-4060	367	4	constant	constant	ADJ
gs-4060	367	5	fragment	fragment	NOUN
gs-4060	367	6	of	of	ADP
gs-4060	367	7	the	the	DET
gs-4060	367	8	antibody	antibody	NOUN
gs-4060	367	9	can	can	AUX
gs-4060	367	10	engage	engage	VERB
gs-4060	367	11	immune	immune	ADJ
gs-4060	367	12	cells	cell	NOUN
gs-4060	367	13	like	like	ADP
gs-4060	367	14	natural	natural	ADJ
gs-4060	367	15	killer	killer	NOUN
gs-4060	367	16	cells	cell	NOUN
gs-4060	367	17	and	and	CCONJ
gs-4060	367	18	macrophages	macrophage	NOUN
gs-4060	367	19	,	,	PUNCT
gs-4060	367	20	leading	lead	VERB
gs-4060	367	21	to	to	ADP
gs-4060	367	22	complement	complement	NOUN
gs-4060	367	23	-	-	PUNCT
gs-4060	367	24	dependent	dependent	ADJ
gs-4060	367	25	cytotoxicity	cytotoxicity	NOUN
gs-4060	367	26	or	or	CCONJ
gs-4060	367	27	antibody	antibody	NOUN
gs-4060	367	28	-	-	PUNCT
gs-4060	367	29	dependent	dependent	ADJ
gs-4060	367	30	cellular	cellular	ADJ
gs-4060	367	31	phagocytosis	phagocytosis	NOUN
gs-4060	367	32	,	,	PUNCT
gs-4060	367	33	thereby	thereby	ADV
gs-4060	367	34	leveraging	leverage	VERB
gs-4060	367	35	the	the	DET
gs-4060	367	36	immune	immune	ADJ
gs-4060	367	37	system	system	NOUN
gs-4060	367	38	for	for	ADP
gs-4060	367	39	tumor	tumor	NOUN
gs-4060	367	40	cell	cell	NOUN
gs-4060	367	41	killing	killing	NOUN
gs-4060	367	42	.	.	PUNCT
gs-4060	368	1	antibody	antibody	NOUN
gs-4060	368	2	-	-	PUNCT
gs-4060	368	3	drug	drug	NOUN
gs-4060	368	4	conjugates	conjugate	NOUN
gs-4060	368	5	represent	represent	VERB
gs-4060	368	6	a	a	DET
gs-4060	368	7	clever	clever	ADJ
gs-4060	368	8	hybrid	hybrid	ADJ
gs-4060	368	9	approach	approach	NOUN
gs-4060	368	10	,	,	PUNCT
gs-4060	368	11	combining	combine	VERB
gs-4060	368	12	the	the	DET
gs-4060	368	13	targeting	targeting	NOUN
gs-4060	368	14	precision	precision	NOUN
gs-4060	368	15	of	of	ADP
gs-4060	368	16	a	a	DET
gs-4060	368	17	monoclonal	monoclonal	NOUN
gs-4060	368	18	antibody	antibody	NOUN
gs-4060	368	19	with	with	ADP
gs-4060	368	20	the	the	DET
gs-4060	368	21	potent	potent	ADJ
gs-4060	368	22	cytotoxic	cytotoxic	ADJ
gs-4060	368	23	payload	payload	NOUN
gs-4060	368	24	of	of	ADP
gs-4060	368	25	a	a	DET
gs-4060	368	26	traditional	traditional	ADJ
gs-4060	368	27	chemotherapeutic	chemotherapeutic	ADJ
gs-4060	368	28	agent	agent	NOUN
gs-4060	368	29	.	.	PUNCT
gs-4060	369	1	the	the	DET
gs-4060	369	2	antibody	antibody	NOUN
gs-4060	369	3	delivers	deliver	VERB
gs-4060	369	4	the	the	DET
gs-4060	369	5	warhead	warhead	NOUN
gs-4060	369	6	directly	directly	ADV
gs-4060	369	7	to	to	ADP
gs-4060	369	8	tumor	tumor	NOUN
gs-4060	369	9	cells	cell	NOUN
gs-4060	369	10	expressing	express	VERB
gs-4060	369	11	the	the	DET
gs-4060	369	12	target	target	NOUN
gs-4060	369	13	antigen	antigen	ADV
gs-4060	369	14	,	,	PUNCT
gs-4060	369	15	where	where	SCONJ
gs-4060	369	16	it	it	PRON
gs-4060	369	17	is	be	AUX
gs-4060	369	18	internalized	internalize	VERB
gs-4060	369	19	,	,	PUNCT
gs-4060	369	20	and	and	CCONJ
gs-4060	369	21	the	the	DET
gs-4060	369	22	cytotoxic	cytotoxic	ADJ
gs-4060	369	23	agent	agent	NOUN
gs-4060	369	24	is	be	AUX
gs-4060	369	25	released	release	VERB
gs-4060	369	26	,	,	PUNCT
gs-4060	369	27	resulting	result	VERB
gs-4060	369	28	in	in	ADP
gs-4060	369	29	a	a	DET
gs-4060	369	30	localized	localized	ADJ
gs-4060	369	31	cell	cell	NOUN
gs-4060	369	32	kill	kill	NOUN
gs-4060	369	33	while	while	SCONJ
gs-4060	369	34	theoretically	theoretically	ADV
gs-4060	369	35	sparing	spare	VERB
gs-4060	369	36	healthy	healthy	ADJ
gs-4060	369	37	tissues	tissue	NOUN
gs-4060	369	38	.	.	PUNCT
gs-4060	370	1	the	the	DET
gs-4060	370	2	mechanism	mechanism	NOUN
gs-4060	370	3	of	of	ADP
gs-4060	370	4	action	action	NOUN
gs-4060	370	5	of	of	ADP
gs-4060	370	6	immunotherapy	immunotherapy	NOUN
gs-4060	370	7	is	be	AUX
gs-4060	370	8	distinct	distinct	ADJ
gs-4060	370	9	from	from	ADP
gs-4060	370	10	any	any	DET
gs-4060	370	11	direct	direct	ADJ
gs-4060	370	12	cytotoxic	cytotoxic	ADJ
gs-4060	370	13	effect	effect	NOUN
gs-4060	370	14	.	.	PUNCT
gs-4060	371	1	immune	immune	ADJ
gs-4060	371	2	checkpoint	checkpoint	NOUN
gs-4060	371	3	inhibitors	inhibitor	NOUN
gs-4060	371	4	function	function	VERB
gs-4060	371	5	by	by	ADP
gs-4060	371	6	blocking	block	VERB
gs-4060	371	7	the	the	DET
gs-4060	371	8	interaction	interaction	NOUN
gs-4060	371	9	between	between	ADP
gs-4060	371	10	inhibitory	inhibitory	ADJ
gs-4060	371	11	receptors	receptor	NOUN
gs-4060	371	12	on	on	ADP
gs-4060	371	13	t	t	NOUN
gs-4060	371	14	-	-	PUNCT
gs-4060	371	15	cells	cell	NOUN
gs-4060	371	16	and	and	CCONJ
gs-4060	371	17	their	their	PRON
gs-4060	371	18	ligands	ligand	NOUN
gs-4060	371	19	.	.	PUNCT
gs-4060	372	1	under	under	ADP
gs-4060	372	2	normal	normal	ADJ
gs-4060	372	3	physiological	physiological	ADJ
gs-4060	372	4	conditions	condition	NOUN
gs-4060	372	5	,	,	PUNCT
gs-4060	372	6	these	these	DET
gs-4060	372	7	checkpoints	checkpoint	NOUN
gs-4060	372	8	are	be	AUX
gs-4060	372	9	crucial	crucial	ADJ
gs-4060	372	10	for	for	ADP
gs-4060	372	11	maintaining	maintain	VERB
gs-4060	372	12	self	self	NOUN
gs-4060	372	13	-	-	PUNCT
gs-4060	372	14	tolerance	tolerance	NOUN
gs-4060	372	15	and	and	CCONJ
gs-4060	372	16	preventing	prevent	VERB
gs-4060	372	17	autoimmunity	autoimmunity	NOUN
gs-4060	372	18	.	.	PUNCT
gs-4060	373	1	tumors	tumor	NOUN
gs-4060	373	2	co	co	VERB
gs-4060	373	3	-	-	VERB
gs-4060	373	4	opt	opt	VERB
gs-4060	373	5	these	these	DET
gs-4060	373	6	pathways	pathway	NOUN
gs-4060	373	7	to	to	PART
gs-4060	373	8	evade	evade	VERB
gs-4060	373	9	immune	immune	ADJ
gs-4060	373	10	surveillance	surveillance	NOUN
gs-4060	373	11	.	.	PUNCT
gs-4060	374	1	by	by	ADP
gs-4060	374	2	administering	administer	VERB
gs-4060	374	3	an	an	DET
gs-4060	374	4	antibody	antibody	NOUN
gs-4060	374	5	that	that	PRON
gs-4060	374	6	binds	bind	VERB
gs-4060	374	7	to	to	ADP
gs-4060	374	8	pd-1	pd-1	X
gs-4060	374	9	,	,	PUNCT
gs-4060	374	10	for	for	ADP
gs-4060	374	11	instance	instance	NOUN
gs-4060	374	12	,	,	PUNCT
gs-4060	374	13	the	the	DET
gs-4060	374	14	inhibitory	inhibitory	ADJ
gs-4060	374	15	signal	signal	NOUN
gs-4060	374	16	is	be	AUX
gs-4060	374	17	prevented	prevent	VERB
gs-4060	374	18	,	,	PUNCT
gs-4060	374	19	effectively	effectively	ADV
gs-4060	374	20	"	"	PUNCT
gs-4060	374	21	releasing	release	VERB
gs-4060	374	22	the	the	DET
gs-4060	374	23	brakes	brake	NOUN
gs-4060	374	24	"	"	PUNCT
gs-4060	374	25	on	on	ADP
gs-4060	374	26	antigen	antigen	NOUN
gs-4060	374	27	-	-	PUNCT
gs-4060	374	28	specific	specific	ADJ
gs-4060	374	29	t	t	NOUN
gs-4060	374	30	-	-	PUNCT
gs-4060	374	31	cells	cell	NOUN
gs-4060	374	32	that	that	PRON
gs-4060	374	33	have	have	AUX
gs-4060	374	34	infiltrated	infiltrate	VERB
gs-4060	374	35	the	the	DET
gs-4060	374	36	tumor	tumor	NOUN
gs-4060	374	37	.	.	PUNCT
gs-4060	375	1	this	this	PRON
gs-4060	375	2	can	can	AUX
gs-4060	375	3	lead	lead	VERB
gs-4060	375	4	to	to	ADP
gs-4060	375	5	the	the	DET
gs-4060	375	6	reactivation	reactivation	NOUN
gs-4060	375	7	and	and	CCONJ
gs-4060	375	8	proliferation	proliferation	NOUN
gs-4060	375	9	of	of	ADP
gs-4060	375	10	these	these	DET
gs-4060	375	11	t	t	NOUN
gs-4060	375	12	-	-	PUNCT
gs-4060	375	13	cell	cell	NOUN
gs-4060	375	14	clones	clone	NOUN
gs-4060	375	15	,	,	PUNCT
gs-4060	375	16	enabling	enable	VERB
gs-4060	375	17	them	they	PRON
gs-4060	375	18	to	to	PART
gs-4060	375	19	mount	mount	VERB
gs-4060	375	20	a	a	DET
gs-4060	375	21	potent	potent	ADJ
gs-4060	375	22	attack	attack	NOUN
gs-4060	375	23	on	on	ADP
gs-4060	375	24	cancer	cancer	NOUN
gs-4060	375	25	cells	cell	NOUN
gs-4060	375	26	.	.	PUNCT
gs-4060	376	1	the	the	DET
gs-4060	376	2	mechanism	mechanism	NOUN
gs-4060	376	3	of	of	ADP
gs-4060	376	4	car	car	NOUN
gs-4060	376	5	t	t	NOUN
gs-4060	376	6	-	-	PUNCT
gs-4060	376	7	cells	cell	NOUN
gs-4060	376	8	is	be	AUX
gs-4060	376	9	more	more	ADV
gs-4060	376	10	direct	direct	ADJ
gs-4060	376	11	.	.	PUNCT
gs-4060	377	1	these	these	DET
gs-4060	377	2	engineered	engineer	VERB
gs-4060	377	3	t	t	PROPN
gs-4060	377	4	-	-	PUNCT
gs-4060	377	5	cells	cell	NOUN
gs-4060	377	6	express	express	VERB
gs-4060	377	7	a	a	DET
gs-4060	377	8	synthetic	synthetic	ADJ
gs-4060	377	9	receptor	receptor	NOUN
gs-4060	377	10	that	that	PRON
gs-4060	377	11	binds	bind	VERB
gs-4060	377	12	to	to	ADP
gs-4060	377	13	a	a	DET
gs-4060	377	14	specific	specific	ADJ
gs-4060	377	15	tumor	tumor	NOUN
gs-4060	377	16	cell	cell	NOUN
gs-4060	377	17	surface	surface	NOUN
gs-4060	377	18	antigen	antigen	ADV
gs-4060	377	19	.	.	PUNCT
gs-4060	378	1	upon	upon	SCONJ
gs-4060	378	2	engagement	engagement	NOUN
gs-4060	378	3	,	,	PUNCT
gs-4060	378	4	the	the	DET
gs-4060	378	5	intracellular	intracellular	ADJ
gs-4060	378	6	signaling	signal	VERB
gs-4060	378	7	domains	domain	NOUN
gs-4060	378	8	of	of	ADP
gs-4060	378	9	the	the	DET
gs-4060	378	10	car	car	NOUN
gs-4060	378	11	activate	activate	VERB
gs-4060	378	12	the	the	DET
gs-4060	378	13	tcell	tcell	NOUN
gs-4060	378	14	,	,	PUNCT
gs-4060	378	15	triggering	trigger	VERB
gs-4060	378	16	its	its	PRON
gs-4060	378	17	cytolytic	cytolytic	ADJ
gs-4060	378	18	machinery	machinery	NOUN
gs-4060	378	19	and	and	CCONJ
gs-4060	378	20	cytokine	cytokine	NOUN
gs-4060	378	21	production	production	NOUN
gs-4060	378	22	,	,	PUNCT
gs-4060	378	23	leading	lead	VERB
gs-4060	378	24	to	to	ADP
gs-4060	378	25	the	the	DET
gs-4060	378	26	destruction	destruction	NOUN
gs-4060	378	27	of	of	ADP
gs-4060	378	28	the	the	DET
gs-4060	378	29	antigen	antigen	NOUN
gs-4060	378	30	-	-	PUNCT
gs-4060	378	31	positive	positive	ADJ
gs-4060	378	32	tumor	tumor	NOUN
gs-4060	378	33	cell	cell	NOUN
gs-4060	378	34	.	.	PUNCT
gs-4060	379	1	this	this	PRON
gs-4060	379	2	represents	represent	VERB
gs-4060	379	3	a	a	DET
gs-4060	379	4	form	form	NOUN
gs-4060	379	5	of	of	ADP
gs-4060	379	6	passive	passive	ADJ
gs-4060	379	7	cellular	cellular	ADJ
gs-4060	379	8	immunotherapy	immunotherapy	NOUN
gs-4060	379	9	,	,	PUNCT
gs-4060	379	10	creating	create	VERB
gs-4060	379	11	a	a	DET
gs-4060	379	12	targeted	target	VERB
gs-4060	379	13	and	and	CCONJ
gs-4060	379	14	potent	potent	ADJ
gs-4060	379	15	immune	immune	ADJ
gs-4060	379	16	response	response	NOUN
gs-4060	379	17	independent	independent	ADJ
gs-4060	379	18	of	of	ADP
gs-4060	379	19	the	the	DET
gs-4060	379	20	endogenous	endogenous	ADJ
gs-4060	379	21	t	t	NOUN
gs-4060	379	22	-	-	PUNCT
gs-4060	379	23	cell	cell	NOUN
gs-4060	379	24	receptor	receptor	NOUN
gs-4060	379	25	.	.	PUNCT
gs-4060	380	1	pharmacological	pharmacological	ADJ
gs-4060	380	2	principles	principle	NOUN
gs-4060	380	3	:	:	PUNCT
gs-4060	380	4	adme	adme	NOUN
gs-4060	380	5	and	and	CCONJ
gs-4060	380	6	beyond	beyond	ADP
gs-4060	380	7	the	the	DET
gs-4060	380	8	pharmacological	pharmacological	ADJ
gs-4060	380	9	profiles	profile	NOUN
gs-4060	380	10	of	of	ADP
gs-4060	380	11	these	these	DET
gs-4060	380	12	novel	novel	ADJ
gs-4060	380	13	agents	agent	NOUN
gs-4060	380	14	differ	differ	VERB
gs-4060	380	15	markedly	markedly	ADV
gs-4060	380	16	from	from	ADP
gs-4060	380	17	traditional	traditional	ADJ
gs-4060	380	18	chemotherapy	chemotherapy	NOUN
gs-4060	380	19	,	,	PUNCT
gs-4060	380	20	with	with	ADP
gs-4060	380	21	significant	significant	ADJ
gs-4060	380	22	implications	implication	NOUN
gs-4060	380	23	for	for	ADP
gs-4060	380	24	their	their	PRON
gs-4060	380	25	clinical	clinical	ADJ
gs-4060	380	26	use	use	NOUN
gs-4060	380	27	.	.	PUNCT
gs-4060	381	1	the	the	DET
gs-4060	381	2	pharmacokinetics	pharmacokinetic	NOUN
gs-4060	381	3	—	—	PUNCT
gs-4060	381	4	what	what	PRON
gs-4060	381	5	the	the	DET
gs-4060	381	6	body	body	NOUN
gs-4060	381	7	does	do	VERB
gs-4060	381	8	to	to	ADP
gs-4060	381	9	the	the	DET
gs-4060	381	10	drug	drug	NOUN
gs-4060	381	11	—	—	PUNCT
gs-4060	381	12	of	of	ADP
gs-4060	381	13	small	small	ADJ
gs-4060	381	14	molecule	molecule	NOUN
gs-4060	381	15	inhibitors	inhibitor	NOUN
gs-4060	381	16	are	be	AUX
gs-4060	381	17	characterized	characterize	VERB
gs-4060	381	18	by	by	ADP
gs-4060	381	19	oral	oral	ADJ
gs-4060	381	20	administration	administration	NOUN
gs-4060	381	21	,	,	PUNCT
gs-4060	381	22	good	good	ADJ
gs-4060	381	23	bioavailability	bioavailability	NOUN
gs-4060	381	24	,	,	PUNCT
gs-4060	381	25	and	and	CCONJ
gs-4060	381	26	often	often	ADV
gs-4060	381	27	high	high	ADJ
gs-4060	381	28	volume	volume	NOUN
gs-4060	381	29	of	of	ADP
gs-4060	381	30	distribution	distribution	NOUN
gs-4060	381	31	,	,	PUNCT
gs-4060	381	32	allowing	allow	VERB
gs-4060	381	33	them	they	PRON
gs-4060	381	34	to	to	PART
gs-4060	381	35	reach	reach	VERB
gs-4060	381	36	intracellular	intracellular	ADJ
gs-4060	381	37	targets	target	NOUN
gs-4060	381	38	.	.	PUNCT
gs-4060	382	1	they	they	PRON
gs-4060	382	2	are	be	AUX
gs-4060	382	3	typically	typically	ADV
gs-4060	382	4	metabolized	metabolize	VERB
gs-4060	382	5	extensively	extensively	ADV
gs-4060	382	6	by	by	ADP
gs-4060	382	7	the	the	DET
gs-4060	382	8	hepatic	hepatic	ADJ
gs-4060	382	9	cytochrome	cytochrome	NOUN
gs-4060	382	10	p450	p450	NUM
gs-4060	382	11	enzyme	enzyme	NOUN
gs-4060	382	12	system	system	NOUN
gs-4060	382	13	,	,	PUNCT
gs-4060	382	14	georgian	georgian	NOUN
gs-4060	382	15	scientists/	scientists/	NUM
gs-4060	382	16	.	.	PUNCT
gs-4060	383	1	7	7	NUM
gs-4060	383	2	n	n	PRON
gs-4060	383	3	3	3	NUM
gs-4060	383	4	,	,	PUNCT
gs-4060	383	5	2025	2025	NUM
gs-4060	383	6	587	587	NUM
gs-4060	383	7	particularly	particularly	ADV
gs-4060	383	8	the	the	DET
gs-4060	383	9	cyp3a4	cyp3a4	NOUN
gs-4060	383	10	isoform	isoform	NOUN
gs-4060	383	11	,	,	PUNCT
gs-4060	383	12	making	make	VERB
gs-4060	383	13	them	they	PRON
gs-4060	383	14	highly	highly	ADV
gs-4060	383	15	susceptible	susceptible	ADJ
gs-4060	383	16	to	to	ADP
gs-4060	383	17	drug	drug	NOUN
gs-4060	383	18	-	-	PUNCT
gs-4060	383	19	drug	drug	NOUN
gs-4060	383	20	interactions	interaction	NOUN
gs-4060	383	21	with	with	ADP
gs-4060	383	22	other	other	ADJ
gs-4060	383	23	agents	agent	NOUN
gs-4060	383	24	that	that	PRON
gs-4060	383	25	induce	induce	VERB
gs-4060	383	26	or	or	CCONJ
gs-4060	383	27	inhibit	inhibit	VERB
gs-4060	383	28	this	this	DET
gs-4060	383	29	pathway	pathway	NOUN
gs-4060	383	30	.	.	PUNCT
gs-4060	384	1	this	this	PRON
gs-4060	384	2	necessitates	necessitate	VERB
gs-4060	384	3	careful	careful	ADJ
gs-4060	384	4	review	review	NOUN
gs-4060	384	5	of	of	ADP
gs-4060	384	6	a	a	DET
gs-4060	384	7	patient	patient	NOUN
gs-4060	384	8	's	's	PART
gs-4060	384	9	concomitant	concomitant	ADJ
gs-4060	384	10	medications	medication	NOUN
gs-4060	384	11	.	.	PUNCT
gs-4060	385	1	their	their	PRON
gs-4060	385	2	elimination	elimination	NOUN
gs-4060	385	3	half	half	ADJ
gs-4060	385	4	-	-	PUNCT
gs-4060	385	5	lives	life	NOUN
gs-4060	385	6	can	can	AUX
gs-4060	385	7	vary	vary	VERB
gs-4060	385	8	widely	widely	ADV
gs-4060	385	9	,	,	PUNCT
gs-4060	385	10	from	from	ADP
gs-4060	385	11	a	a	DET
gs-4060	385	12	few	few	ADJ
gs-4060	385	13	hours	hour	NOUN
gs-4060	385	14	to	to	ADP
gs-4060	385	15	several	several	ADJ
gs-4060	385	16	days	day	NOUN
gs-4060	385	17	,	,	PUNCT
gs-4060	385	18	informing	inform	VERB
gs-4060	385	19	their	their	PRON
gs-4060	385	20	dosing	dose	VERB
gs-4060	385	21	schedule	schedule	NOUN
gs-4060	385	22	,	,	PUNCT
gs-4060	385	23	which	which	PRON
gs-4060	385	24	is	be	AUX
gs-4060	385	25	often	often	ADV
gs-4060	385	26	continuous	continuous	ADJ
gs-4060	385	27	on	on	ADP
gs-4060	385	28	a	a	DET
gs-4060	385	29	daily	daily	ADJ
gs-4060	385	30	basis	basis	NOUN
gs-4060	385	31	.	.	PUNCT
gs-4060	386	1	in	in	ADP
gs-4060	386	2	contrast	contrast	NOUN
gs-4060	386	3	,	,	PUNCT
gs-4060	386	4	large	large	ADJ
gs-4060	386	5	biologic	biologic	NOUN
gs-4060	386	6	agents	agent	NOUN
gs-4060	386	7	like	like	ADP
gs-4060	386	8	monoclonal	monoclonal	NOUN
gs-4060	386	9	antibodies	antibody	NOUN
gs-4060	386	10	have	have	VERB
gs-4060	386	11	distinctly	distinctly	ADV
gs-4060	386	12	different	different	ADJ
gs-4060	386	13	pharmacokinetics	pharmacokinetic	NOUN
gs-4060	386	14	.	.	PUNCT
gs-4060	387	1	due	due	ADP
gs-4060	387	2	to	to	ADP
gs-4060	387	3	their	their	PRON
gs-4060	387	4	protein	protein	NOUN
gs-4060	387	5	nature	nature	NOUN
gs-4060	387	6	,	,	PUNCT
gs-4060	387	7	they	they	PRON
gs-4060	387	8	must	must	AUX
gs-4060	387	9	be	be	AUX
gs-4060	387	10	administered	administer	VERB
gs-4060	387	11	parenterally	parenterally	ADV
gs-4060	387	12	,	,	PUNCT
gs-4060	387	13	as	as	SCONJ
gs-4060	387	14	they	they	PRON
gs-4060	387	15	would	would	AUX
gs-4060	387	16	be	be	AUX
gs-4060	387	17	digested	digest	VERB
gs-4060	387	18	in	in	ADP
gs-4060	387	19	the	the	DET
gs-4060	387	20	gastrointestinal	gastrointestinal	ADJ
gs-4060	387	21	tract	tract	NOUN
gs-4060	387	22	.	.	PUNCT
gs-4060	388	1	they	they	PRON
gs-4060	388	2	are	be	AUX
gs-4060	388	3	not	not	PART
gs-4060	388	4	metabolized	metabolize	VERB
gs-4060	388	5	by	by	ADP
gs-4060	388	6	cytochrome	cytochrome	ADJ
gs-4060	388	7	p450	p450	NUM
gs-4060	388	8	enzymes	enzyme	NOUN
gs-4060	388	9	but	but	CCONJ
gs-4060	388	10	are	be	AUX
gs-4060	388	11	instead	instead	ADV
gs-4060	388	12	degraded	degrade	VERB
gs-4060	388	13	into	into	ADP
gs-4060	388	14	peptides	peptide	NOUN
gs-4060	388	15	and	and	CCONJ
gs-4060	388	16	amino	amino	ADJ
gs-4060	388	17	acids	acid	NOUN
gs-4060	388	18	via	via	ADP
gs-4060	388	19	proteolytic	proteolytic	ADJ
gs-4060	388	20	catabolism	catabolism	NOUN
gs-4060	388	21	throughout	throughout	ADP
gs-4060	388	22	the	the	DET
gs-4060	388	23	body	body	NOUN
gs-4060	388	24	,	,	PUNCT
gs-4060	388	25	often	often	ADV
gs-4060	388	26	involving	involve	VERB
gs-4060	388	27	the	the	DET
gs-4060	388	28	reticuloendothelial	reticuloendothelial	ADJ
gs-4060	388	29	system	system	NOUN
gs-4060	388	30	.	.	PUNCT
gs-4060	389	1	their	their	PRON
gs-4060	389	2	large	large	ADJ
gs-4060	389	3	size	size	NOUN
gs-4060	389	4	confines	confine	NOUN
gs-4060	389	5	them	they	PRON
gs-4060	389	6	primarily	primarily	ADV
gs-4060	389	7	to	to	ADP
gs-4060	389	8	the	the	DET
gs-4060	389	9	plasma	plasma	NOUN
gs-4060	389	10	and	and	CCONJ
gs-4060	389	11	interstitial	interstitial	ADJ
gs-4060	389	12	fluid	fluid	NOUN
gs-4060	389	13	,	,	PUNCT
gs-4060	389	14	resulting	result	VERB
gs-4060	389	15	in	in	ADP
gs-4060	389	16	a	a	DET
gs-4060	389	17	low	low	ADJ
gs-4060	389	18	volume	volume	NOUN
gs-4060	389	19	of	of	ADP
gs-4060	389	20	distribution	distribution	NOUN
gs-4060	389	21	.	.	PUNCT
gs-4060	390	1	a	a	DET
gs-4060	390	2	key	key	ADJ
gs-4060	390	3	feature	feature	NOUN
gs-4060	390	4	of	of	ADP
gs-4060	390	5	monoclonal	monoclonal	NOUN
gs-4060	390	6	antibody	antibody	NOUN
gs-4060	390	7	pharmacokinetics	pharmacokinetic	NOUN
gs-4060	390	8	is	be	AUX
gs-4060	390	9	their	their	PRON
gs-4060	390	10	long	long	ADJ
gs-4060	390	11	elimination	elimination	NOUN
gs-4060	390	12	half	half	ADJ
gs-4060	390	13	-	-	PUNCT
gs-4060	390	14	life	life	NOUN
gs-4060	390	15	,	,	PUNCT
gs-4060	390	16	often	often	ADV
gs-4060	390	17	stretching	stretch	VERB
gs-4060	390	18	to	to	ADP
gs-4060	390	19	weeks	week	NOUN
gs-4060	390	20	or	or	CCONJ
gs-4060	390	21	even	even	ADV
gs-4060	390	22	months	month	NOUN
gs-4060	390	23	,	,	PUNCT
gs-4060	390	24	which	which	PRON
gs-4060	390	25	is	be	AUX
gs-4060	390	26	attributable	attributable	ADJ
gs-4060	390	27	to	to	ADP
gs-4060	390	28	protection	protection	NOUN
gs-4060	390	29	from	from	ADP
gs-4060	390	30	catabolism	catabolism	NOUN
gs-4060	390	31	by	by	ADP
gs-4060	390	32	neonatal	neonatal	ADJ
gs-4060	390	33	fc	fc	PROPN
gs-4060	390	34	receptormediated	receptormediate	VERB
gs-4060	390	35	recycling	recycling	NOUN
gs-4060	390	36	.	.	PUNCT
gs-4060	391	1	this	this	PRON
gs-4060	391	2	allows	allow	VERB
gs-4060	391	3	for	for	ADP
gs-4060	391	4	less	less	ADV
gs-4060	391	5	frequent	frequent	ADJ
gs-4060	391	6	,	,	PUNCT
gs-4060	391	7	intermittent	intermittent	ADJ
gs-4060	391	8	dosing	dosing	NOUN
gs-4060	391	9	schedules	schedule	NOUN
gs-4060	391	10	,	,	PUNCT
gs-4060	391	11	such	such	ADJ
gs-4060	391	12	as	as	ADP
gs-4060	391	13	every	every	DET
gs-4060	391	14	two	two	NUM
gs-4060	391	15	,	,	PUNCT
gs-4060	391	16	three	three	NUM
gs-4060	391	17	,	,	PUNCT
gs-4060	391	18	or	or	CCONJ
gs-4060	391	19	four	four	NUM
gs-4060	391	20	weeks	week	NOUN
gs-4060	391	21	.	.	PUNCT
gs-4060	392	1	the	the	DET
gs-4060	392	2	pharmacodynamics	pharmacodynamic	NOUN
gs-4060	392	3	—	—	PUNCT
gs-4060	392	4	what	what	PRON
gs-4060	392	5	the	the	DET
gs-4060	392	6	drug	drug	NOUN
gs-4060	392	7	does	do	VERB
gs-4060	392	8	to	to	ADP
gs-4060	392	9	the	the	DET
gs-4060	392	10	body	body	NOUN
gs-4060	392	11	—	—	PUNCT
gs-4060	392	12	are	be	AUX
gs-4060	392	13	equally	equally	ADV
gs-4060	392	14	complex	complex	ADJ
gs-4060	392	15	.	.	PUNCT
gs-4060	393	1	for	for	ADP
gs-4060	393	2	targeted	target	VERB
gs-4060	393	3	therapies	therapy	NOUN
gs-4060	393	4	,	,	PUNCT
gs-4060	393	5	the	the	DET
gs-4060	393	6	relationship	relationship	NOUN
gs-4060	393	7	between	between	ADP
gs-4060	393	8	drug	drug	NOUN
gs-4060	393	9	concentration	concentration	NOUN
gs-4060	393	10	and	and	CCONJ
gs-4060	393	11	effect	effect	NOUN
gs-4060	393	12	is	be	AUX
gs-4060	393	13	often	often	ADV
gs-4060	393	14	linked	link	VERB
gs-4060	393	15	to	to	ADP
gs-4060	393	16	the	the	DET
gs-4060	393	17	saturation	saturation	NOUN
gs-4060	393	18	of	of	ADP
gs-4060	393	19	the	the	DET
gs-4060	393	20	target	target	NOUN
gs-4060	393	21	pathway	pathway	NOUN
gs-4060	393	22	.	.	PUNCT
gs-4060	394	1	the	the	DET
gs-4060	394	2	therapeutic	therapeutic	ADJ
gs-4060	394	3	effect	effect	NOUN
gs-4060	394	4	is	be	AUX
gs-4060	394	5	not	not	PART
gs-4060	394	6	always	always	ADV
gs-4060	394	7	directly	directly	ADV
gs-4060	394	8	proportional	proportional	ADJ
gs-4060	394	9	to	to	ADP
gs-4060	394	10	the	the	DET
gs-4060	394	11	maximum	maximum	ADJ
gs-4060	394	12	concentration	concentration	NOUN
gs-4060	394	13	achieved	achieve	VERB
gs-4060	394	14	but	but	CCONJ
gs-4060	394	15	is	be	AUX
gs-4060	394	16	more	more	ADV
gs-4060	394	17	closely	closely	ADV
gs-4060	394	18	related	relate	VERB
gs-4060	394	19	to	to	ADP
gs-4060	394	20	the	the	DET
gs-4060	394	21	time	time	NOUN
gs-4060	394	22	during	during	ADP
gs-4060	394	23	which	which	PRON
gs-4060	394	24	the	the	DET
gs-4060	394	25	drug	drug	NOUN
gs-4060	394	26	concentration	concentration	NOUN
gs-4060	394	27	remains	remain	VERB
gs-4060	394	28	above	above	ADP
gs-4060	394	29	a	a	DET
gs-4060	394	30	threshold	threshold	NOUN
gs-4060	394	31	required	require	VERB
gs-4060	394	32	for	for	ADP
gs-4060	394	33	target	target	NOUN
gs-4060	394	34	inhibition	inhibition	NOUN
gs-4060	394	35	.	.	PUNCT
gs-4060	395	1	this	this	PRON
gs-4060	395	2	has	have	AUX
gs-4060	395	3	led	lead	VERB
gs-4060	395	4	to	to	ADP
gs-4060	395	5	the	the	DET
gs-4060	395	6	concept	concept	NOUN
gs-4060	395	7	of	of	ADP
gs-4060	395	8	a	a	DET
gs-4060	395	9	target	target	NOUN
gs-4060	395	10	trough	trough	NOUN
gs-4060	395	11	concentration	concentration	NOUN
gs-4060	395	12	for	for	ADP
gs-4060	395	13	many	many	ADJ
gs-4060	395	14	tyrosine	tyrosine	NOUN
gs-4060	395	15	kinase	kinase	PROPN
gs-4060	395	16	inhibitors	inhibitor	NOUN
gs-4060	395	17	,	,	PUNCT
gs-4060	395	18	which	which	PRON
gs-4060	395	19	is	be	AUX
gs-4060	395	20	monitored	monitor	VERB
gs-4060	395	21	to	to	PART
gs-4060	395	22	ensure	ensure	VERB
gs-4060	395	23	continuous	continuous	ADJ
gs-4060	395	24	pathway	pathway	NOUN
gs-4060	395	25	suppression	suppression	NOUN
gs-4060	395	26	.	.	PUNCT
gs-4060	396	1	for	for	ADP
gs-4060	396	2	immunotherapies	immunotherapy	NOUN
gs-4060	396	3	,	,	PUNCT
gs-4060	396	4	the	the	DET
gs-4060	396	5	pharmacodynamic	pharmacodynamic	ADJ
gs-4060	396	6	relationship	relationship	NOUN
gs-4060	396	7	is	be	AUX
gs-4060	396	8	even	even	ADV
gs-4060	396	9	more	more	ADV
gs-4060	396	10	complex	complex	ADJ
gs-4060	396	11	and	and	CCONJ
gs-4060	396	12	delayed	delay	VERB
gs-4060	396	13	.	.	PUNCT
gs-4060	397	1	the	the	DET
gs-4060	397	2	administration	administration	NOUN
gs-4060	397	3	of	of	ADP
gs-4060	397	4	a	a	DET
gs-4060	397	5	checkpoint	checkpoint	NOUN
gs-4060	397	6	inhibitor	inhibitor	NOUN
gs-4060	397	7	does	do	AUX
gs-4060	397	8	not	not	PART
gs-4060	397	9	immediately	immediately	ADV
gs-4060	397	10	lyse	lyse	VERB
gs-4060	397	11	tumor	tumor	NOUN
gs-4060	397	12	cells	cell	NOUN
gs-4060	397	13	.	.	PUNCT
gs-4060	398	1	instead	instead	ADV
gs-4060	398	2	,	,	PUNCT
gs-4060	398	3	it	it	PRON
gs-4060	398	4	initiates	initiate	VERB
gs-4060	398	5	a	a	DET
gs-4060	398	6	biological	biological	ADJ
gs-4060	398	7	process	process	NOUN
gs-4060	398	8	that	that	PRON
gs-4060	398	9	requires	require	VERB
gs-4060	398	10	time	time	NOUN
gs-4060	398	11	for	for	ADP
gs-4060	398	12	t	t	NOUN
gs-4060	398	13	-	-	PUNCT
gs-4060	398	14	cell	cell	NOUN
gs-4060	398	15	activation	activation	NOUN
gs-4060	398	16	,	,	PUNCT
gs-4060	398	17	clonal	clonal	ADJ
gs-4060	398	18	expansion	expansion	NOUN
gs-4060	398	19	,	,	PUNCT
gs-4060	398	20	and	and	CCONJ
gs-4060	398	21	migration	migration	NOUN
gs-4060	398	22	to	to	ADP
gs-4060	398	23	tumor	tumor	NOUN
gs-4060	398	24	sites	site	NOUN
gs-4060	398	25	.	.	PUNCT
gs-4060	399	1	this	this	PRON
gs-4060	399	2	explains	explain	VERB
gs-4060	399	3	the	the	DET
gs-4060	399	4	characteristically	characteristically	ADV
gs-4060	399	5	delayed	delay	VERB
gs-4060	399	6	onset	onset	NOUN
gs-4060	399	7	of	of	ADP
gs-4060	399	8	clinical	clinical	ADJ
gs-4060	399	9	response	response	NOUN
gs-4060	399	10	and	and	CCONJ
gs-4060	399	11	the	the	DET
gs-4060	399	12	unusual	unusual	ADJ
gs-4060	399	13	patterns	pattern	NOUN
gs-4060	399	14	of	of	ADP
gs-4060	399	15	response	response	NOUN
gs-4060	399	16	such	such	ADJ
gs-4060	399	17	as	as	ADP
gs-4060	399	18	pseudoprogression	pseudoprogression	NOUN
gs-4060	399	19	,	,	PUNCT
gs-4060	399	20	where	where	SCONJ
gs-4060	399	21	tumors	tumor	NOUN
gs-4060	399	22	may	may	AUX
gs-4060	399	23	appear	appear	VERB
gs-4060	399	24	to	to	PART
gs-4060	399	25	grow	grow	VERB
gs-4060	399	26	initially	initially	ADV
gs-4060	399	27	due	due	ADP
gs-4060	399	28	to	to	ADP
gs-4060	399	29	immune	immune	ADJ
gs-4060	399	30	cell	cell	NOUN
gs-4060	399	31	infiltration	infiltration	NOUN
gs-4060	399	32	before	before	ADP
gs-4060	399	33	subsequently	subsequently	ADV
gs-4060	399	34	regressing	regress	VERB
gs-4060	399	35	.	.	PUNCT
gs-4060	400	1	clinical	clinical	ADJ
gs-4060	400	2	applications	application	NOUN
gs-4060	400	3	and	and	CCONJ
gs-4060	400	4	the	the	DET
gs-4060	400	5	paradigm	paradigm	NOUN
gs-4060	400	6	of	of	ADP
gs-4060	400	7	precision	precision	NOUN
gs-4060	400	8	medicine	medicine	NOUN
gs-4060	400	9	the	the	DET
gs-4060	400	10	clinical	clinical	ADJ
gs-4060	400	11	deployment	deployment	NOUN
gs-4060	400	12	of	of	ADP
gs-4060	400	13	these	these	DET
gs-4060	400	14	agents	agent	NOUN
gs-4060	400	15	has	have	AUX
gs-4060	400	16	fundamentally	fundamentally	ADV
gs-4060	400	17	altered	alter	VERB
gs-4060	400	18	treatment	treatment	NOUN
gs-4060	400	19	algorithms	algorithm	NOUN
gs-4060	400	20	and	and	CCONJ
gs-4060	400	21	patient	patient	ADJ
gs-4060	400	22	outcomes	outcome	NOUN
gs-4060	400	23	across	across	ADP
gs-4060	400	24	a	a	DET
gs-4060	400	25	vast	vast	ADJ
gs-4060	400	26	spectrum	spectrum	NOUN
gs-4060	400	27	of	of	ADP
gs-4060	400	28	malignancies	malignancy	NOUN
gs-4060	400	29	.	.	PUNCT
gs-4060	401	1	the	the	DET
gs-4060	401	2	efficacy	efficacy	NOUN
gs-4060	401	3	of	of	ADP
gs-4060	401	4	these	these	DET
gs-4060	401	5	drugs	drug	NOUN
gs-4060	401	6	is	be	AUX
gs-4060	401	7	inextricably	inextricably	ADV
gs-4060	401	8	linked	link	VERB
gs-4060	401	9	to	to	ADP
gs-4060	401	10	the	the	DET
gs-4060	401	11	presence	presence	NOUN
gs-4060	401	12	of	of	ADP
gs-4060	401	13	the	the	DET
gs-4060	401	14	specific	specific	ADJ
gs-4060	401	15	molecular	molecular	ADJ
gs-4060	401	16	target	target	NOUN
gs-4060	401	17	they	they	PRON
gs-4060	401	18	are	be	AUX
gs-4060	401	19	designed	design	VERB
gs-4060	401	20	to	to	PART
gs-4060	401	21	inhibit	inhibit	VERB
gs-4060	401	22	,	,	PUNCT
gs-4060	401	23	cementing	cement	VERB
gs-4060	401	24	the	the	DET
gs-4060	401	25	role	role	NOUN
gs-4060	401	26	of	of	ADP
gs-4060	401	27	comprehensive	comprehensive	ADJ
gs-4060	401	28	biomarker	biomarker	NOUN
gs-4060	401	29	testing	testing	NOUN
gs-4060	401	30	as	as	ADP
gs-4060	401	31	a	a	DET
gs-4060	401	32	standard	standard	NOUN
gs-4060	401	33	of	of	ADP
gs-4060	401	34	care	care	NOUN
gs-4060	401	35	in	in	ADP
gs-4060	401	36	modern	modern	ADJ
gs-4060	401	37	oncology	oncology	NOUN
gs-4060	401	38	.	.	PUNCT
gs-4060	402	1	tumor	tumor	NOUN
gs-4060	402	2	genotyping	genotype	VERB
gs-4060	402	3	via	via	ADP
gs-4060	402	4	next	next	ADJ
gs-4060	402	5	-	-	PUNCT
gs-4060	402	6	generation	generation	NOUN
gs-4060	402	7	sequencing	sequence	VERB
gs-4060	402	8	panels	panel	NOUN
gs-4060	402	9	is	be	AUX
gs-4060	402	10	now	now	ADV
gs-4060	402	11	routine	routine	ADJ
gs-4060	402	12	to	to	PART
gs-4060	402	13	identify	identify	VERB
gs-4060	402	14	actionable	actionable	ADJ
gs-4060	402	15	mutations	mutation	NOUN
gs-4060	402	16	,	,	PUNCT
gs-4060	402	17	and	and	CCONJ
gs-4060	402	18	immunohistochemistry	immunohistochemistry	NOUN
gs-4060	402	19	is	be	AUX
gs-4060	402	20	used	use	VERB
gs-4060	402	21	to	to	PART
gs-4060	402	22	detect	detect	VERB
gs-4060	402	23	protein	protein	NOUN
gs-4060	402	24	expression	expression	NOUN
gs-4060	402	25	levels	level	NOUN
gs-4060	402	26	of	of	ADP
gs-4060	402	27	targets	target	NOUN
gs-4060	402	28	like	like	ADP
gs-4060	402	29	her2	her2	PROPN
gs-4060	402	30	or	or	CCONJ
gs-4060	402	31	pdl1	pdl1	NOUN
gs-4060	402	32	.	.	PUNCT
gs-4060	403	1	the	the	DET
gs-4060	403	2	success	success	NOUN
gs-4060	403	3	of	of	ADP
gs-4060	403	4	targeted	target	VERB
gs-4060	403	5	therapy	therapy	NOUN
gs-4060	403	6	is	be	AUX
gs-4060	403	7	exemplified	exemplify	VERB
gs-4060	403	8	in	in	ADP
gs-4060	403	9	diseases	disease	NOUN
gs-4060	403	10	such	such	ADJ
gs-4060	403	11	as	as	ADP
gs-4060	403	12	chronic	chronic	ADJ
gs-4060	403	13	myeloid	myeloid	NOUN
gs-4060	403	14	leukemia	leukemia	NOUN
gs-4060	403	15	,	,	PUNCT
gs-4060	403	16	where	where	SCONJ
gs-4060	403	17	bcr	bcr	PROPN
gs-4060	403	18	-	-	ADJ
gs-4060	403	19	abl	abl	NOUN
gs-4060	403	20	inhibitors	inhibitor	NOUN
gs-4060	403	21	have	have	AUX
gs-4060	403	22	transformed	transform	VERB
gs-4060	403	23	a	a	DET
gs-4060	403	24	once	once	ADV
gs-4060	403	25	-	-	PUNCT
gs-4060	403	26	fatal	fatal	ADJ
gs-4060	403	27	diagnosis	diagnosis	NOUN
gs-4060	403	28	into	into	ADP
gs-4060	403	29	a	a	DET
gs-4060	403	30	chronic	chronic	NOUN
gs-4060	403	31	,	,	PUNCT
gs-4060	403	32	manageable	manageable	ADJ
gs-4060	403	33	condition	condition	NOUN
gs-4060	403	34	with	with	ADP
gs-4060	403	35	near	near	ADV
gs-4060	403	36	-	-	PUNCT
gs-4060	403	37	normal	normal	ADJ
gs-4060	403	38	life	life	NOUN
gs-4060	403	39	expectancy	expectancy	NOUN
gs-4060	403	40	.	.	PUNCT
gs-4060	404	1	in	in	ADP
gs-4060	404	2	non	non	ADJ
gs-4060	404	3	-	-	ADJ
gs-4060	404	4	small	small	ADJ
gs-4060	404	5	cell	cell	NOUN
gs-4060	404	6	lung	lung	NOUN
gs-4060	404	7	cancer	cancer	NOUN
gs-4060	404	8	,	,	PUNCT
gs-4060	404	9	the	the	DET
gs-4060	404	10	identification	identification	NOUN
gs-4060	404	11	of	of	ADP
gs-4060	404	12	driver	driver	NOUN
gs-4060	404	13	alterations	alteration	NOUN
gs-4060	404	14	in	in	ADP
gs-4060	404	15	genes	gene	NOUN
gs-4060	404	16	like	like	ADP
gs-4060	404	17	egfr	egfr	NOUN
gs-4060	404	18	,	,	PUNCT
gs-4060	404	19	alk	alk	PROPN
gs-4060	404	20	,	,	PUNCT
gs-4060	404	21	ros1	ros1	PROPN
gs-4060	404	22	,	,	PUNCT
gs-4060	404	23	and	and	CCONJ
gs-4060	404	24	braf	braf	NOUN
gs-4060	404	25	has	have	AUX
gs-4060	404	26	created	create	VERB
gs-4060	404	27	multiple	multiple	ADJ
gs-4060	404	28	subsets	subset	NOUN
gs-4060	404	29	of	of	ADP
gs-4060	404	30	the	the	DET
gs-4060	404	31	disease	disease	NOUN
gs-4060	404	32	,	,	PUNCT
gs-4060	404	33	each	each	PRON
gs-4060	404	34	with	with	ADP
gs-4060	404	35	a	a	DET
gs-4060	404	36	corresponding	correspond	VERB
gs-4060	404	37	highly	highly	ADV
gs-4060	404	38	effective	effective	ADJ
gs-4060	404	39	targeted	target	VERB
gs-4060	404	40	therapy	therapy	NOUN
gs-4060	404	41	,	,	PUNCT
gs-4060	404	42	leading	lead	VERB
gs-4060	404	43	to	to	ADP
gs-4060	404	44	unprecedented	unprecedented	ADJ
gs-4060	404	45	response	response	NOUN
gs-4060	404	46	rates	rate	NOUN
gs-4060	404	47	and	and	CCONJ
gs-4060	404	48	progression	progression	NOUN
gs-4060	404	49	-	-	PUNCT
gs-4060	404	50	free	free	ADJ
gs-4060	404	51	survival	survival	NOUN
gs-4060	404	52	compared	compare	VERB
gs-4060	404	53	to	to	ADP
gs-4060	404	54	historical	historical	ADJ
gs-4060	404	55	chemotherapy	chemotherapy	NOUN
gs-4060	404	56	standards	standard	NOUN
gs-4060	404	57	.	.	PUNCT
gs-4060	405	1	similarly	similarly	ADV
gs-4060	405	2	,	,	PUNCT
gs-4060	405	3	the	the	DET
gs-4060	405	4	use	use	NOUN
gs-4060	405	5	of	of	ADP
gs-4060	405	6	parp	parp	ADJ
gs-4060	405	7	inhibitors	inhibitor	NOUN
gs-4060	405	8	in	in	ADP
gs-4060	405	9	ovarian	ovarian	ADJ
gs-4060	405	10	and	and	CCONJ
gs-4060	405	11	breast	breast	NOUN
gs-4060	405	12	cancers	cancer	NOUN
gs-4060	405	13	with	with	ADP
gs-4060	405	14	brca	brca	PROPN
gs-4060	405	15	mutations	mutation	NOUN
gs-4060	405	16	demonstrates	demonstrate	VERB
gs-4060	405	17	the	the	DET
gs-4060	405	18	powerful	powerful	ADJ
gs-4060	405	19	clinical	clinical	ADJ
gs-4060	405	20	application	application	NOUN
gs-4060	405	21	of	of	ADP
gs-4060	405	22	the	the	DET
gs-4060	405	23	synthetic	synthetic	ADJ
gs-4060	405	24	lethality	lethality	NOUN
gs-4060	405	25	principle	principle	NOUN
gs-4060	405	26	.	.	PUNCT
gs-4060	406	1	georgian	georgian	NOUN
gs-4060	406	2	scientists/	scientists/	NUM
gs-4060	406	3	.	.	PUNCT
gs-4060	407	1	7	7	NUM
gs-4060	407	2	n	n	PRON
gs-4060	407	3	3	3	NUM
gs-4060	407	4	,	,	PUNCT
gs-4060	407	5	2025	2025	NUM
gs-4060	407	6	588	588	NUM
gs-4060	407	7	immunotherapy	immunotherapy	NOUN
gs-4060	407	8	,	,	PUNCT
gs-4060	407	9	particularly	particularly	ADV
gs-4060	407	10	checkpoint	checkpoint	NOUN
gs-4060	407	11	inhibition	inhibition	NOUN
gs-4060	407	12	,	,	PUNCT
gs-4060	407	13	has	have	AUX
gs-4060	407	14	produced	produce	VERB
gs-4060	407	15	durable	durable	ADJ
gs-4060	407	16	,	,	PUNCT
gs-4060	407	17	long	long	ADJ
gs-4060	407	18	-	-	PUNCT
gs-4060	407	19	term	term	NOUN
gs-4060	407	20	remissions	remission	NOUN
gs-4060	407	21	in	in	ADP
gs-4060	407	22	a	a	DET
gs-4060	407	23	subset	subset	NOUN
gs-4060	407	24	of	of	ADP
gs-4060	407	25	patients	patient	NOUN
gs-4060	407	26	with	with	ADP
gs-4060	407	27	advanced	advanced	ADJ
gs-4060	407	28	cancers	cancer	NOUN
gs-4060	407	29	that	that	PRON
gs-4060	407	30	were	be	AUX
gs-4060	407	31	previously	previously	ADV
gs-4060	407	32	considered	consider	VERB
gs-4060	407	33	uniformly	uniformly	ADV
gs-4060	407	34	fatal	fatal	ADJ
gs-4060	407	35	.	.	PUNCT
gs-4060	408	1	this	this	PRON
gs-4060	408	2	has	have	AUX
gs-4060	408	3	been	be	AUX
gs-4060	408	4	most	most	ADV
gs-4060	408	5	dramatically	dramatically	ADV
gs-4060	408	6	observed	observe	VERB
gs-4060	408	7	in	in	ADP
gs-4060	408	8	melanoma	melanoma	NOUN
gs-4060	408	9	,	,	PUNCT
gs-4060	408	10	renal	renal	ADJ
gs-4060	408	11	cell	cell	NOUN
gs-4060	408	12	carcinoma	carcinoma	NOUN
gs-4060	408	13	,	,	PUNCT
gs-4060	408	14	and	and	CCONJ
gs-4060	408	15	non	non	ADJ
gs-4060	408	16	-	-	ADJ
gs-4060	408	17	small	small	ADJ
gs-4060	408	18	cell	cell	NOUN
gs-4060	408	19	lung	lung	NOUN
gs-4060	408	20	cancer	cancer	NOUN
gs-4060	408	21	,	,	PUNCT
gs-4060	408	22	where	where	SCONJ
gs-4060	408	23	anti	anti	ADJ
gs-4060	408	24	-	-	ADJ
gs-4060	408	25	pd-1	pd-1	ADJ
gs-4060	408	26	agents	agent	NOUN
gs-4060	408	27	have	have	AUX
gs-4060	408	28	become	become	VERB
gs-4060	408	29	cornerstone	cornerstone	NOUN
gs-4060	408	30	therapies	therapy	NOUN
gs-4060	408	31	.	.	PUNCT
gs-4060	409	1	the	the	DET
gs-4060	409	2	approval	approval	NOUN
gs-4060	409	3	of	of	ADP
gs-4060	409	4	checkpoint	checkpoint	NOUN
gs-4060	409	5	inhibitors	inhibitor	NOUN
gs-4060	409	6	is	be	AUX
gs-4060	409	7	often	often	ADV
gs-4060	409	8	tied	tie	VERB
gs-4060	409	9	to	to	ADP
gs-4060	409	10	the	the	DET
gs-4060	409	11	measurement	measurement	NOUN
gs-4060	409	12	of	of	ADP
gs-4060	409	13	pd	pd	PROPN
gs-4060	409	14	-	-	PROPN
gs-4060	409	15	l1	l1	PROPN
gs-4060	409	16	expression	expression	NOUN
gs-4060	409	17	levels	level	NOUN
gs-4060	409	18	,	,	PUNCT
gs-4060	409	19	though	though	SCONJ
gs-4060	409	20	other	other	ADJ
gs-4060	409	21	biomarkers	biomarker	NOUN
gs-4060	409	22	such	such	ADJ
gs-4060	409	23	as	as	ADP
gs-4060	409	24	tumor	tumor	NOUN
gs-4060	409	25	mutational	mutational	ADJ
gs-4060	409	26	burden	burden	NOUN
gs-4060	409	27	and	and	CCONJ
gs-4060	409	28	microsatellite	microsatellite	ADJ
gs-4060	409	29	instability	instability	NOUN
gs-4060	409	30	status	status	NOUN
gs-4060	409	31	are	be	AUX
gs-4060	409	32	also	also	ADV
gs-4060	409	33	used	use	VERB
gs-4060	409	34	to	to	PART
gs-4060	409	35	predict	predict	VERB
gs-4060	409	36	response	response	NOUN
gs-4060	409	37	.	.	PUNCT
gs-4060	410	1	car	car	NOUN
gs-4060	410	2	t	t	NOUN
gs-4060	410	3	-	-	PUNCT
gs-4060	410	4	cell	cell	NOUN
gs-4060	410	5	therapy	therapy	NOUN
gs-4060	410	6	has	have	AUX
gs-4060	410	7	achieved	achieve	VERB
gs-4060	410	8	remarkable	remarkable	ADJ
gs-4060	410	9	success	success	NOUN
gs-4060	410	10	in	in	ADP
gs-4060	410	11	certain	certain	ADJ
gs-4060	410	12	hematological	hematological	ADJ
gs-4060	410	13	malignancies	malignancy	NOUN
gs-4060	410	14	,	,	PUNCT
gs-4060	410	15	leading	lead	VERB
gs-4060	410	16	to	to	ADP
gs-4060	410	17	high	high	ADJ
gs-4060	410	18	rates	rate	NOUN
gs-4060	410	19	of	of	ADP
gs-4060	410	20	complete	complete	ADJ
gs-4060	410	21	and	and	CCONJ
gs-4060	410	22	lasting	lasting	ADJ
gs-4060	410	23	remission	remission	NOUN
gs-4060	410	24	in	in	ADP
gs-4060	410	25	patients	patient	NOUN
gs-4060	410	26	with	with	ADP
gs-4060	410	27	chemorefractory	chemorefractory	ADJ
gs-4060	410	28	acute	acute	NOUN
gs-4060	410	29	lymphoblastic	lymphoblastic	ADJ
gs-4060	410	30	leukemia	leukemia	NOUN
gs-4060	410	31	and	and	CCONJ
gs-4060	410	32	diffuse	diffuse	VERB
gs-4060	410	33	large	large	ADJ
gs-4060	410	34	b	b	NOUN
gs-4060	410	35	-	-	PUNCT
gs-4060	410	36	cell	cell	NOUN
gs-4060	410	37	lymphoma	lymphoma	NOUN
gs-4060	410	38	,	,	PUNCT
gs-4060	410	39	a	a	DET
gs-4060	410	40	feat	feat	NOUN
gs-4060	410	41	previously	previously	ADV
gs-4060	410	42	thought	think	VERB
gs-4060	410	43	unattainable	unattainable	ADJ
gs-4060	410	44	.	.	PUNCT
gs-4060	411	1	these	these	DET
gs-4060	411	2	advances	advance	NOUN
gs-4060	411	3	have	have	AUX
gs-4060	411	4	reshaped	reshape	VERB
gs-4060	411	5	clinical	clinical	ADJ
gs-4060	411	6	trial	trial	NOUN
gs-4060	411	7	design	design	NOUN
gs-4060	411	8	and	and	CCONJ
gs-4060	411	9	treatment	treatment	NOUN
gs-4060	411	10	endpoints	endpoint	NOUN
gs-4060	411	11	.	.	PUNCT
gs-4060	412	1	therapies	therapy	NOUN
gs-4060	412	2	are	be	AUX
gs-4060	412	3	increasingly	increasingly	ADV
gs-4060	412	4	studied	study	VERB
gs-4060	412	5	in	in	ADP
gs-4060	412	6	biomarker	biomarker	NOUN
gs-4060	412	7	-	-	PUNCT
gs-4060	412	8	selected	select	VERB
gs-4060	412	9	populations	population	NOUN
gs-4060	412	10	.	.	PUNCT
gs-4060	413	1	the	the	DET
gs-4060	413	2	traditional	traditional	ADJ
gs-4060	413	3	dose	dose	NOUN
gs-4060	413	4	-	-	PUNCT
gs-4060	413	5	escalation	escalation	NOUN
gs-4060	413	6	phase	phase	NOUN
gs-4060	413	7	i	i	PRON
gs-4060	413	8	trial	trial	NOUN
gs-4060	413	9	designed	design	VERB
gs-4060	413	10	to	to	PART
gs-4060	413	11	find	find	VERB
gs-4060	413	12	the	the	DET
gs-4060	413	13	maximum	maximum	ADJ
gs-4060	413	14	tolerated	tolerate	VERB
gs-4060	413	15	dose	dose	NOUN
gs-4060	413	16	is	be	AUX
gs-4060	413	17	sometimes	sometimes	ADV
gs-4060	413	18	replaced	replace	VERB
gs-4060	413	19	with	with	ADP
gs-4060	413	20	trials	trial	NOUN
gs-4060	413	21	seeking	seek	VERB
gs-4060	413	22	the	the	DET
gs-4060	413	23	optimal	optimal	ADJ
gs-4060	413	24	biological	biological	ADJ
gs-4060	413	25	dose	dose	NOUN
gs-4060	413	26	for	for	ADP
gs-4060	413	27	targeted	target	VERB
gs-4060	413	28	agents	agent	NOUN
gs-4060	413	29	.	.	PUNCT
gs-4060	414	1	furthermore	furthermore	ADV
gs-4060	414	2	,	,	PUNCT
gs-4060	414	3	the	the	DET
gs-4060	414	4	chronic	chronic	ADJ
gs-4060	414	5	administration	administration	NOUN
gs-4060	414	6	of	of	ADP
gs-4060	414	7	these	these	DET
gs-4060	414	8	drugs	drug	NOUN
gs-4060	414	9	,	,	PUNCT
gs-4060	414	10	often	often	ADV
gs-4060	414	11	for	for	ADP
gs-4060	414	12	years	year	NOUN
gs-4060	414	13	,	,	PUNCT
gs-4060	414	14	has	have	AUX
gs-4060	414	15	shifted	shift	VERB
gs-4060	414	16	the	the	DET
gs-4060	414	17	treatment	treatment	NOUN
gs-4060	414	18	paradigm	paradigm	NOUN
gs-4060	414	19	for	for	ADP
gs-4060	414	20	advanced	advanced	ADJ
gs-4060	414	21	cancer	cancer	NOUN
gs-4060	414	22	from	from	ADP
gs-4060	414	23	an	an	DET
gs-4060	414	24	acute	acute	NOUN
gs-4060	414	25	,	,	PUNCT
gs-4060	414	26	palliative	palliative	ADJ
gs-4060	414	27	intent	intent	NOUN
gs-4060	414	28	to	to	ADP
gs-4060	414	29	a	a	DET
gs-4060	414	30	chronic	chronic	ADJ
gs-4060	414	31	disease	disease	NOUN
gs-4060	414	32	management	management	NOUN
gs-4060	414	33	model	model	NOUN
gs-4060	414	34	for	for	ADP
gs-4060	414	35	a	a	DET
gs-4060	414	36	significant	significant	ADJ
gs-4060	414	37	number	number	NOUN
gs-4060	414	38	of	of	ADP
gs-4060	414	39	patients	patient	NOUN
gs-4060	414	40	.	.	PUNCT
gs-4060	415	1	toxicities	toxicity	NOUN
gs-4060	415	2	and	and	CCONJ
gs-4060	415	3	their	their	PRON
gs-4060	415	4	management	management	NOUN
gs-4060	415	5	:	:	PUNCT
gs-4060	415	6	a	a	DET
gs-4060	415	7	new	new	ADJ
gs-4060	415	8	clinical	clinical	ADJ
gs-4060	415	9	challenge	challenge	NOUN
gs-4060	415	10	the	the	DET
gs-4060	415	11	toxicity	toxicity	NOUN
gs-4060	415	12	profiles	profile	NOUN
gs-4060	415	13	of	of	ADP
gs-4060	415	14	these	these	DET
gs-4060	415	15	novel	novel	ADJ
gs-4060	415	16	agents	agent	NOUN
gs-4060	415	17	are	be	AUX
gs-4060	415	18	as	as	ADV
gs-4060	415	19	distinctive	distinctive	ADJ
gs-4060	415	20	as	as	ADP
gs-4060	415	21	their	their	PRON
gs-4060	415	22	mechanisms	mechanism	NOUN
gs-4060	415	23	,	,	PUNCT
gs-4060	415	24	requiring	require	VERB
gs-4060	415	25	oncologists	oncologist	NOUN
gs-4060	415	26	to	to	PART
gs-4060	415	27	develop	develop	VERB
gs-4060	415	28	a	a	DET
gs-4060	415	29	new	new	ADJ
gs-4060	415	30	skillset	skillset	NOUN
gs-4060	415	31	for	for	ADP
gs-4060	415	32	recognition	recognition	NOUN
gs-4060	415	33	and	and	CCONJ
gs-4060	415	34	management	management	NOUN
gs-4060	415	35	.	.	PUNCT
gs-4060	416	1	the	the	DET
gs-4060	416	2	adverse	adverse	ADJ
gs-4060	416	3	events	event	NOUN
gs-4060	416	4	associated	associate	VERB
gs-4060	416	5	with	with	ADP
gs-4060	416	6	targeted	target	VERB
gs-4060	416	7	therapies	therapy	NOUN
gs-4060	416	8	are	be	AUX
gs-4060	416	9	often	often	ADV
gs-4060	416	10	mechanism	mechanism	NOUN
gs-4060	416	11	-	-	PUNCT
gs-4060	416	12	based	base	VERB
gs-4060	416	13	"	"	PUNCT
gs-4060	416	14	on	on	ADP
gs-4060	416	15	-	-	PUNCT
gs-4060	416	16	target	target	NOUN
gs-4060	416	17	"	"	PUNCT
gs-4060	416	18	effects	effect	NOUN
gs-4060	416	19	,	,	PUNCT
gs-4060	416	20	resulting	result	VERB
gs-4060	416	21	from	from	ADP
gs-4060	416	22	the	the	DET
gs-4060	416	23	inhibition	inhibition	NOUN
gs-4060	416	24	of	of	ADP
gs-4060	416	25	the	the	DET
gs-4060	416	26	intended	intend	VERB
gs-4060	416	27	target	target	NOUN
gs-4060	416	28	in	in	ADP
gs-4060	416	29	healthy	healthy	ADJ
gs-4060	416	30	tissues	tissue	NOUN
gs-4060	416	31	that	that	PRON
gs-4060	416	32	rely	rely	VERB
gs-4060	416	33	on	on	ADP
gs-4060	416	34	the	the	DET
gs-4060	416	35	same	same	ADJ
gs-4060	416	36	pathway	pathway	NOUN
gs-4060	416	37	for	for	ADP
gs-4060	416	38	normal	normal	ADJ
gs-4060	416	39	function	function	NOUN
gs-4060	416	40	.	.	PUNCT
gs-4060	417	1	for	for	ADP
gs-4060	417	2	example	example	NOUN
gs-4060	417	3	,	,	PUNCT
gs-4060	417	4	inhibitors	inhibitor	NOUN
gs-4060	417	5	of	of	ADP
gs-4060	417	6	the	the	DET
gs-4060	417	7	epidermal	epidermal	ADJ
gs-4060	417	8	growth	growth	NOUN
gs-4060	417	9	factor	factor	NOUN
gs-4060	417	10	receptor	receptor	NOUN
gs-4060	417	11	almost	almost	ADV
gs-4060	417	12	universally	universally	ADV
gs-4060	417	13	cause	cause	VERB
gs-4060	417	14	a	a	DET
gs-4060	417	15	characteristic	characteristic	ADJ
gs-4060	417	16	papulopustular	papulopustular	ADJ
gs-4060	417	17	rash	rash	NOUN
gs-4060	417	18	and	and	CCONJ
gs-4060	417	19	diarrhea	diarrhea	NOUN
gs-4060	417	20	,	,	PUNCT
gs-4060	417	21	as	as	SCONJ
gs-4060	417	22	egfr	egfr	NOUN
gs-4060	417	23	plays	play	VERB
gs-4060	417	24	a	a	DET
gs-4060	417	25	key	key	ADJ
gs-4060	417	26	role	role	NOUN
gs-4060	417	27	in	in	ADP
gs-4060	417	28	skin	skin	NOUN
gs-4060	417	29	and	and	CCONJ
gs-4060	417	30	gastrointestinal	gastrointestinal	ADJ
gs-4060	417	31	epithelial	epithelial	ADJ
gs-4060	417	32	homeostasis	homeostasis	NOUN
gs-4060	417	33	.	.	PUNCT
gs-4060	418	1	inhibitors	inhibitor	NOUN
gs-4060	418	2	of	of	ADP
gs-4060	418	3	the	the	DET
gs-4060	418	4	vascular	vascular	ADJ
gs-4060	418	5	endothelial	endothelial	ADJ
gs-4060	418	6	growth	growth	NOUN
gs-4060	418	7	factor	factor	NOUN
gs-4060	418	8	pathway	pathway	NOUN
gs-4060	418	9	frequently	frequently	ADV
gs-4060	418	10	lead	lead	VERB
gs-4060	418	11	to	to	ADP
gs-4060	418	12	hypertension	hypertension	NOUN
gs-4060	418	13	,	,	PUNCT
gs-4060	418	14	proteinuria	proteinuria	NOUN
gs-4060	418	15	,	,	PUNCT
gs-4060	418	16	and	and	CCONJ
gs-4060	418	17	impaired	impaired	ADJ
gs-4060	418	18	wound	wound	NOUN
gs-4060	418	19	healing	healing	NOUN
gs-4060	418	20	due	due	ADP
gs-4060	418	21	to	to	ADP
gs-4060	418	22	their	their	PRON
gs-4060	418	23	effect	effect	NOUN
gs-4060	418	24	on	on	ADP
gs-4060	418	25	normal	normal	ADJ
gs-4060	418	26	angiogenesis	angiogenesis	NOUN
gs-4060	418	27	.	.	PUNCT
gs-4060	419	1	these	these	DET
gs-4060	419	2	toxicities	toxicity	NOUN
gs-4060	419	3	are	be	AUX
gs-4060	419	4	generally	generally	ADV
gs-4060	419	5	dose	dose	VERB
gs-4060	419	6	-	-	PUNCT
gs-4060	419	7	dependent	dependent	ADJ
gs-4060	419	8	and	and	CCONJ
gs-4060	419	9	manageable	manageable	ADJ
gs-4060	419	10	with	with	ADP
gs-4060	419	11	supportive	supportive	ADJ
gs-4060	419	12	care	care	NOUN
gs-4060	419	13	,	,	PUNCT
gs-4060	419	14	dose	dose	NOUN
gs-4060	419	15	modifications	modification	NOUN
gs-4060	419	16	,	,	PUNCT
gs-4060	419	17	or	or	CCONJ
gs-4060	419	18	treatment	treatment	NOUN
gs-4060	419	19	interruptions	interruption	NOUN
gs-4060	419	20	.	.	PUNCT
gs-4060	420	1	the	the	DET
gs-4060	420	2	toxicities	toxicity	NOUN
gs-4060	420	3	of	of	ADP
gs-4060	420	4	immunotherapy	immunotherapy	NOUN
gs-4060	420	5	,	,	PUNCT
gs-4060	420	6	however	however	ADV
gs-4060	420	7	,	,	PUNCT
gs-4060	420	8	are	be	AUX
gs-4060	420	9	fundamentally	fundamentally	ADV
gs-4060	420	10	different	different	ADJ
gs-4060	420	11	and	and	CCONJ
gs-4060	420	12	are	be	AUX
gs-4060	420	13	classified	classify	VERB
gs-4060	420	14	as	as	ADP
gs-4060	420	15	immune	immune	NOUN
gs-4060	420	16	-	-	PUNCT
gs-4060	420	17	related	relate	VERB
gs-4060	420	18	adverse	adverse	ADJ
gs-4060	420	19	events	event	NOUN
gs-4060	420	20	.	.	PUNCT
gs-4060	421	1	these	these	PRON
gs-4060	421	2	arise	arise	VERB
gs-4060	421	3	from	from	ADP
gs-4060	421	4	the	the	DET
gs-4060	421	5	breaking	breaking	NOUN
gs-4060	421	6	of	of	ADP
gs-4060	421	7	peripheral	peripheral	ADJ
gs-4060	421	8	immune	immune	ADJ
gs-4060	421	9	tolerance	tolerance	NOUN
gs-4060	421	10	and	and	CCONJ
gs-4060	421	11	the	the	DET
gs-4060	421	12	unleashing	unleashing	NOUN
gs-4060	421	13	of	of	ADP
gs-4060	421	14	autoreactive	autoreactive	ADJ
gs-4060	421	15	t	t	PROPN
gs-4060	421	16	-	-	PUNCT
gs-4060	421	17	cells	cell	NOUN
gs-4060	421	18	,	,	PUNCT
gs-4060	421	19	leading	lead	VERB
gs-4060	421	20	to	to	ADP
gs-4060	421	21	a	a	DET
gs-4060	421	22	spectrum	spectrum	NOUN
gs-4060	421	23	of	of	ADP
gs-4060	421	24	autoimmune	autoimmune	ADJ
gs-4060	421	25	-	-	PUNCT
gs-4060	421	26	like	like	ADJ
gs-4060	421	27	phenomena	phenomenon	NOUN
gs-4060	421	28	that	that	PRON
gs-4060	421	29	can	can	AUX
gs-4060	421	30	affect	affect	VERB
gs-4060	421	31	any	any	DET
gs-4060	421	32	organ	organ	NOUN
gs-4060	421	33	system	system	NOUN
gs-4060	421	34	.	.	PUNCT
gs-4060	422	1	common	common	ADJ
gs-4060	422	2	iraes	irae	NOUN
gs-4060	422	3	include	include	VERB
gs-4060	422	4	dermatologic	dermatologic	ADJ
gs-4060	422	5	toxicities	toxicity	NOUN
gs-4060	422	6	like	like	ADP
gs-4060	422	7	rash	rash	NOUN
gs-4060	422	8	and	and	CCONJ
gs-4060	422	9	pruritus	pruritus	NOUN
gs-4060	422	10	;	;	PUNCT
gs-4060	422	11	gastrointestinal	gastrointestinal	ADJ
gs-4060	422	12	toxicities	toxicity	NOUN
gs-4060	422	13	such	such	ADJ
gs-4060	422	14	as	as	ADP
gs-4060	422	15	colitis	colitis	NOUN
gs-4060	422	16	,	,	PUNCT
gs-4060	422	17	which	which	PRON
gs-4060	422	18	can	can	AUX
gs-4060	422	19	present	present	VERB
gs-4060	422	20	with	with	ADP
gs-4060	422	21	severe	severe	ADJ
gs-4060	422	22	diarrhea	diarrhea	NOUN
gs-4060	422	23	;	;	PUNCT
gs-4060	422	24	endocrine	endocrine	ADJ
gs-4060	422	25	toxicities	toxicity	NOUN
gs-4060	422	26	including	include	VERB
gs-4060	422	27	hypophysitis	hypophysitis	NOUN
gs-4060	422	28	,	,	PUNCT
gs-4060	422	29	thyroiditis	thyroiditis	NOUN
gs-4060	422	30	,	,	PUNCT
gs-4060	422	31	and	and	CCONJ
gs-4060	422	32	adrenal	adrenal	ADJ
gs-4060	422	33	insufficiency	insufficiency	NOUN
gs-4060	422	34	;	;	PUNCT
gs-4060	422	35	and	and	CCONJ
gs-4060	422	36	hepatic	hepatic	ADJ
gs-4060	422	37	toxicities	toxicity	NOUN
gs-4060	422	38	manifesting	manifest	VERB
gs-4060	422	39	as	as	ADP
gs-4060	422	40	hepatitis	hepatitis	NOUN
gs-4060	422	41	.	.	PUNCT
gs-4060	423	1	more	more	ADV
gs-4060	423	2	rarely	rarely	ADV
gs-4060	423	3	,	,	PUNCT
gs-4060	423	4	but	but	CCONJ
gs-4060	423	5	with	with	ADP
gs-4060	423	6	greater	great	ADJ
gs-4060	423	7	severity	severity	NOUN
gs-4060	423	8	,	,	PUNCT
gs-4060	423	9	pneumonitis	pneumonitis	NOUN
gs-4060	423	10	,	,	PUNCT
gs-4060	423	11	myocarditis	myocarditis	PROPN
gs-4060	423	12	,	,	PUNCT
gs-4060	423	13	and	and	CCONJ
gs-4060	423	14	neurological	neurological	ADJ
gs-4060	423	15	toxicities	toxicity	NOUN
gs-4060	423	16	can	can	AUX
gs-4060	423	17	occur	occur	VERB
gs-4060	423	18	.	.	PUNCT
gs-4060	424	1	the	the	DET
gs-4060	424	2	management	management	NOUN
gs-4060	424	3	of	of	ADP
gs-4060	424	4	these	these	DET
gs-4060	424	5	events	event	NOUN
gs-4060	424	6	is	be	AUX
gs-4060	424	7	based	base	VERB
gs-4060	424	8	on	on	ADP
gs-4060	424	9	their	their	PRON
gs-4060	424	10	grade	grade	NOUN
gs-4060	424	11	of	of	ADP
gs-4060	424	12	severity	severity	NOUN
gs-4060	424	13	and	and	CCONJ
gs-4060	424	14	involves	involve	VERB
gs-4060	424	15	the	the	DET
gs-4060	424	16	use	use	NOUN
gs-4060	424	17	of	of	ADP
gs-4060	424	18	corticosteroids	corticosteroid	NOUN
gs-4060	424	19	and	and	CCONJ
gs-4060	424	20	other	other	ADJ
gs-4060	424	21	immunosuppressive	immunosuppressive	ADJ
gs-4060	424	22	agents	agent	NOUN
gs-4060	424	23	like	like	ADP
gs-4060	424	24	infliximab	infliximab	NOUN
gs-4060	424	25	.	.	PUNCT
gs-4060	425	1	the	the	DET
gs-4060	425	2	paramount	paramount	ADJ
gs-4060	425	3	principles	principle	NOUN
gs-4060	425	4	are	be	AUX
gs-4060	425	5	early	early	ADJ
gs-4060	425	6	recognition	recognition	NOUN
gs-4060	425	7	,	,	PUNCT
gs-4060	425	8	prompt	prompt	ADJ
gs-4060	425	9	intervention	intervention	NOUN
gs-4060	425	10	,	,	PUNCT
gs-4060	425	11	and	and	CCONJ
gs-4060	425	12	patient	patient	ADJ
gs-4060	425	13	education	education	NOUN
gs-4060	425	14	,	,	PUNCT
gs-4060	425	15	as	as	SCONJ
gs-4060	425	16	delays	delay	NOUN
gs-4060	425	17	can	can	AUX
gs-4060	425	18	lead	lead	VERB
gs-4060	425	19	to	to	ADP
gs-4060	425	20	life	life	NOUN
gs-4060	425	21	-	-	PUNCT
gs-4060	425	22	threatening	threaten	VERB
gs-4060	425	23	complications	complication	NOUN
gs-4060	425	24	.	.	PUNCT
gs-4060	426	1	this	this	PRON
gs-4060	426	2	requires	require	VERB
gs-4060	426	3	a	a	DET
gs-4060	426	4	high	high	ADJ
gs-4060	426	5	index	index	NOUN
gs-4060	426	6	of	of	ADP
gs-4060	426	7	suspicion	suspicion	NOUN
gs-4060	426	8	and	and	CCONJ
gs-4060	426	9	a	a	DET
gs-4060	426	10	multidisciplinary	multidisciplinary	ADJ
gs-4060	426	11	approach	approach	NOUN
gs-4060	426	12	to	to	PART
gs-4060	426	13	care	care	VERB
gs-4060	426	14	.	.	PUNCT
gs-4060	427	1	the	the	DET
gs-4060	427	2	management	management	NOUN
gs-4060	427	3	of	of	ADP
gs-4060	427	4	toxicities	toxicity	NOUN
gs-4060	427	5	from	from	ADP
gs-4060	427	6	car	car	NOUN
gs-4060	427	7	t	t	NOUN
gs-4060	427	8	-	-	PUNCT
gs-4060	427	9	cell	cell	NOUN
gs-4060	427	10	therapy	therapy	NOUN
gs-4060	427	11	presents	present	VERB
gs-4060	427	12	another	another	DET
gs-4060	427	13	unique	unique	ADJ
gs-4060	427	14	challenge	challenge	NOUN
gs-4060	427	15	,	,	PUNCT
gs-4060	427	16	dominated	dominate	VERB
gs-4060	427	17	by	by	ADP
gs-4060	427	18	two	two	NUM
gs-4060	427	19	primary	primary	ADJ
gs-4060	427	20	syndromes	syndrome	NOUN
gs-4060	427	21	:	:	PUNCT
gs-4060	427	22	cytokine	cytokine	ADJ
gs-4060	427	23	release	release	NOUN
gs-4060	427	24	syndrome	syndrome	NOUN
gs-4060	427	25	and	and	CCONJ
gs-4060	427	26	immune	immune	ADJ
gs-4060	427	27	effector	effector	NOUN
gs-4060	427	28	cellassociated	cellassociate	VERB
gs-4060	427	29	neurotoxicity	neurotoxicity	NOUN
gs-4060	427	30	syndrome	syndrome	NOUN
gs-4060	427	31	.	.	PUNCT
gs-4060	428	1	cytokine	cytokine	ADJ
gs-4060	428	2	release	release	NOUN
gs-4060	428	3	syndrome	syndrome	NOUN
gs-4060	428	4	is	be	AUX
gs-4060	428	5	a	a	DET
gs-4060	428	6	systemic	systemic	ADJ
gs-4060	428	7	inflammatory	inflammatory	ADJ
gs-4060	428	8	response	response	NOUN
gs-4060	428	9	georgian	georgian	NOUN
gs-4060	428	10	scientists/	scientists/	NUM
gs-4060	428	11	.	.	PUNCT
gs-4060	429	1	7	7	NUM
gs-4060	429	2	n	n	PRON
gs-4060	429	3	3	3	NUM
gs-4060	429	4	,	,	PUNCT
gs-4060	429	5	2025	2025	NUM
gs-4060	429	6	589	589	NUM
gs-4060	429	7	caused	cause	VERB
gs-4060	429	8	by	by	ADP
gs-4060	429	9	the	the	DET
gs-4060	429	10	massive	massive	ADJ
gs-4060	429	11	activation	activation	NOUN
gs-4060	429	12	and	and	CCONJ
gs-4060	429	13	proliferation	proliferation	NOUN
gs-4060	429	14	of	of	ADP
gs-4060	429	15	car	car	NOUN
gs-4060	429	16	t	t	NOUN
gs-4060	429	17	-	-	PUNCT
gs-4060	429	18	cells	cell	NOUN
gs-4060	429	19	and	and	CCONJ
gs-4060	429	20	the	the	DET
gs-4060	429	21	subsequent	subsequent	ADJ
gs-4060	429	22	release	release	NOUN
gs-4060	429	23	of	of	ADP
gs-4060	429	24	a	a	DET
gs-4060	429	25	flood	flood	NOUN
gs-4060	429	26	of	of	ADP
gs-4060	429	27	inflammatory	inflammatory	ADJ
gs-4060	429	28	cytokines	cytokine	NOUN
gs-4060	429	29	.	.	PUNCT
gs-4060	430	1	it	it	PRON
gs-4060	430	2	presents	present	VERB
gs-4060	430	3	with	with	ADP
gs-4060	430	4	a	a	DET
gs-4060	430	5	spectrum	spectrum	NOUN
gs-4060	430	6	of	of	ADP
gs-4060	430	7	symptoms	symptom	NOUN
gs-4060	430	8	,	,	PUNCT
gs-4060	430	9	from	from	ADP
gs-4060	430	10	high	high	ADJ
gs-4060	430	11	fevers	fever	NOUN
gs-4060	430	12	and	and	CCONJ
gs-4060	430	13	flu	flu	NOUN
gs-4060	430	14	-	-	PUNCT
gs-4060	430	15	like	like	ADJ
gs-4060	430	16	symptoms	symptom	NOUN
gs-4060	430	17	to	to	ADP
gs-4060	430	18	hypotension	hypotension	NOUN
gs-4060	430	19	,	,	PUNCT
gs-4060	430	20	capillary	capillary	ADJ
gs-4060	430	21	leak	leak	NOUN
gs-4060	430	22	,	,	PUNCT
gs-4060	430	23	and	and	CCONJ
gs-4060	430	24	end	end	NOUN
gs-4060	430	25	-	-	PUNCT
gs-4060	430	26	organ	organ	NOUN
gs-4060	430	27	dysfunction	dysfunction	NOUN
gs-4060	430	28	.	.	PUNCT
gs-4060	431	1	immune	immune	ADJ
gs-4060	431	2	effector	effector	NOUN
gs-4060	431	3	cellassociated	cellassociate	VERB
gs-4060	431	4	neurotoxicity	neurotoxicity	NOUN
gs-4060	431	5	syndrome	syndrome	NOUN
gs-4060	431	6	can	can	AUX
gs-4060	431	7	present	present	VERB
gs-4060	431	8	with	with	ADP
gs-4060	431	9	headaches	headache	NOUN
gs-4060	431	10	,	,	PUNCT
gs-4060	431	11	confusion	confusion	NOUN
gs-4060	431	12	,	,	PUNCT
gs-4060	431	13	aphasia	aphasia	NOUN
gs-4060	431	14	,	,	PUNCT
gs-4060	431	15	seizures	seizure	NOUN
gs-4060	431	16	,	,	PUNCT
gs-4060	431	17	and	and	CCONJ
gs-4060	431	18	cerebral	cerebral	ADJ
gs-4060	431	19	edema	edema	NOUN
gs-4060	431	20	.	.	PUNCT
gs-4060	432	1	both	both	DET
gs-4060	432	2	syndromes	syndrome	NOUN
gs-4060	432	3	require	require	VERB
gs-4060	432	4	sophisticated	sophisticated	ADJ
gs-4060	432	5	supportive	supportive	ADJ
gs-4060	432	6	care	care	NOUN
gs-4060	432	7	in	in	ADP
gs-4060	432	8	an	an	DET
gs-4060	432	9	acute	acute	NOUN
gs-4060	432	10	setting	setting	NOUN
gs-4060	432	11	and	and	CCONJ
gs-4060	432	12	the	the	DET
gs-4060	432	13	judicious	judicious	ADJ
gs-4060	432	14	use	use	NOUN
gs-4060	432	15	of	of	ADP
gs-4060	432	16	immunomodulatory	immunomodulatory	ADJ
gs-4060	432	17	agents	agent	NOUN
gs-4060	432	18	like	like	ADP
gs-4060	432	19	the	the	DET
gs-4060	432	20	interleukin-6	interleukin-6	NUM
gs-4060	432	21	receptor	receptor	NOUN
gs-4060	432	22	antagonist	antagonist	NOUN
gs-4060	432	23	tocilizumab	tocilizumab	NOUN
gs-4060	432	24	.	.	PUNCT
gs-4060	433	1	the	the	DET
gs-4060	433	2	development	development	NOUN
gs-4060	433	3	and	and	CCONJ
gs-4060	433	4	integration	integration	NOUN
gs-4060	433	5	of	of	ADP
gs-4060	433	6	new	new	ADJ
gs-4060	433	7	anticancer	anticancer	NOUN
gs-4060	433	8	drugs	drug	NOUN
gs-4060	433	9	based	base	VERB
gs-4060	433	10	on	on	ADP
gs-4060	433	11	scientific	scientific	ADJ
gs-4060	433	12	principles	principle	NOUN
gs-4060	433	13	of	of	ADP
gs-4060	433	14	tumor	tumor	NOUN
gs-4060	433	15	biology	biology	NOUN
gs-4060	433	16	have	have	AUX
gs-4060	433	17	irrevocably	irrevocably	ADV
gs-4060	433	18	changed	change	VERB
gs-4060	433	19	the	the	DET
gs-4060	433	20	practice	practice	NOUN
gs-4060	433	21	of	of	ADP
gs-4060	433	22	oncology	oncology	NOUN
gs-4060	433	23	.	.	PUNCT
gs-4060	434	1	the	the	DET
gs-4060	434	2	results	result	NOUN
gs-4060	434	3	of	of	ADP
gs-4060	434	4	this	this	DET
gs-4060	434	5	analysis	analysis	NOUN
gs-4060	434	6	demonstrate	demonstrate	VERB
gs-4060	434	7	a	a	DET
gs-4060	434	8	clear	clear	ADJ
gs-4060	434	9	evolution	evolution	NOUN
gs-4060	434	10	from	from	ADP
gs-4060	434	11	non	non	ADJ
gs-4060	434	12	-	-	ADJ
gs-4060	434	13	specific	specific	ADJ
gs-4060	434	14	cytotoxicity	cytotoxicity	NOUN
gs-4060	434	15	to	to	ADP
gs-4060	434	16	targeted	target	VERB
gs-4060	434	17	intervention	intervention	NOUN
gs-4060	434	18	and	and	CCONJ
gs-4060	434	19	immune	immune	ADJ
gs-4060	434	20	modulation	modulation	NOUN
gs-4060	434	21	.	.	PUNCT
gs-4060	435	1	this	this	PRON
gs-4060	435	2	has	have	AUX
gs-4060	435	3	been	be	AUX
gs-4060	435	4	made	make	VERB
gs-4060	435	5	possible	possible	ADJ
gs-4060	435	6	by	by	ADP
gs-4060	435	7	a	a	DET
gs-4060	435	8	refined	refined	ADJ
gs-4060	435	9	classification	classification	NOUN
gs-4060	435	10	system	system	NOUN
gs-4060	435	11	,	,	PUNCT
gs-4060	435	12	a	a	DET
gs-4060	435	13	deep	deep	ADJ
gs-4060	435	14	understanding	understanding	NOUN
gs-4060	435	15	of	of	ADP
gs-4060	435	16	molecular	molecular	ADJ
gs-4060	435	17	mechanisms	mechanism	NOUN
gs-4060	435	18	,	,	PUNCT
gs-4060	435	19	sophisticated	sophisticated	ADJ
gs-4060	435	20	pharmacological	pharmacological	ADJ
gs-4060	435	21	principles	principle	NOUN
gs-4060	435	22	,	,	PUNCT
gs-4060	435	23	and	and	CCONJ
gs-4060	435	24	the	the	DET
gs-4060	435	25	clinical	clinical	ADJ
gs-4060	435	26	validation	validation	NOUN
gs-4060	435	27	of	of	ADP
gs-4060	435	28	precision	precision	NOUN
gs-4060	435	29	medicine	medicine	NOUN
gs-4060	435	30	.	.	PUNCT
gs-4060	436	1	however	however	ADV
gs-4060	436	2	,	,	PUNCT
gs-4060	436	3	significant	significant	ADJ
gs-4060	436	4	challenges	challenge	NOUN
gs-4060	436	5	persist	persist	VERB
gs-4060	436	6	.	.	PUNCT
gs-4060	437	1	primary	primary	ADJ
gs-4060	437	2	and	and	CCONJ
gs-4060	437	3	acquired	acquire	VERB
gs-4060	437	4	resistance	resistance	NOUN
gs-4060	437	5	to	to	ADP
gs-4060	437	6	targeted	target	VERB
gs-4060	437	7	therapies	therapy	NOUN
gs-4060	437	8	remains	remain	VERB
gs-4060	437	9	a	a	DET
gs-4060	437	10	major	major	ADJ
gs-4060	437	11	obstacle	obstacle	NOUN
gs-4060	437	12	,	,	PUNCT
gs-4060	437	13	driven	drive	VERB
gs-4060	437	14	by	by	ADP
gs-4060	437	15	tumor	tumor	NOUN
gs-4060	437	16	heterogeneity	heterogeneity	NOUN
gs-4060	437	17	,	,	PUNCT
gs-4060	437	18	clonal	clonal	ADJ
gs-4060	437	19	evolution	evolution	NOUN
gs-4060	437	20	,	,	PUNCT
gs-4060	437	21	and	and	CCONJ
gs-4060	437	22	the	the	DET
gs-4060	437	23	activation	activation	NOUN
gs-4060	437	24	of	of	ADP
gs-4060	437	25	bypass	bypass	NOUN
gs-4060	437	26	signaling	signal	VERB
gs-4060	437	27	pathways	pathway	NOUN
gs-4060	437	28	.	.	PUNCT
gs-4060	438	1	combination	combination	NOUN
gs-4060	438	2	strategies	strategy	NOUN
gs-4060	438	3	,	,	PUNCT
gs-4060	438	4	targeting	target	VERB
gs-4060	438	5	multiple	multiple	ADJ
gs-4060	438	6	pathways	pathway	NOUN
gs-4060	438	7	simultaneously	simultaneously	ADV
gs-4060	438	8	or	or	CCONJ
gs-4060	438	9	sequentially	sequentially	ADV
gs-4060	438	10	,	,	PUNCT
gs-4060	438	11	are	be	AUX
gs-4060	438	12	a	a	DET
gs-4060	438	13	key	key	ADJ
gs-4060	438	14	area	area	NOUN
gs-4060	438	15	of	of	ADP
gs-4060	438	16	ongoing	ongoing	ADJ
gs-4060	438	17	research	research	NOUN
gs-4060	438	18	.	.	PUNCT
gs-4060	439	1	for	for	ADP
gs-4060	439	2	immunotherapy	immunotherapy	NOUN
gs-4060	439	3	,	,	PUNCT
gs-4060	439	4	the	the	DET
gs-4060	439	5	inability	inability	NOUN
gs-4060	439	6	to	to	PART
gs-4060	439	7	predict	predict	VERB
gs-4060	439	8	response	response	NOUN
gs-4060	439	9	accurately	accurately	ADV
gs-4060	439	10	and	and	CCONJ
gs-4060	439	11	the	the	DET
gs-4060	439	12	fact	fact	NOUN
gs-4060	439	13	that	that	SCONJ
gs-4060	439	14	a	a	DET
gs-4060	439	15	majority	majority	NOUN
gs-4060	439	16	of	of	ADP
gs-4060	439	17	patients	patient	NOUN
gs-4060	439	18	do	do	AUX
gs-4060	439	19	not	not	PART
gs-4060	439	20	derive	derive	VERB
gs-4060	439	21	long	long	ADJ
gs-4060	439	22	-	-	PUNCT
gs-4060	439	23	term	term	NOUN
gs-4060	439	24	benefit	benefit	NOUN
gs-4060	439	25	highlight	highlight	VERB
gs-4060	439	26	the	the	DET
gs-4060	439	27	need	need	NOUN
gs-4060	439	28	for	for	ADP
gs-4060	439	29	better	well	ADJ
gs-4060	439	30	biomarkers	biomarker	NOUN
gs-4060	439	31	and	and	CCONJ
gs-4060	439	32	strategies	strategy	NOUN
gs-4060	439	33	to	to	PART
gs-4060	439	34	overcome	overcome	VERB
gs-4060	439	35	immunosuppressive	immunosuppressive	ADJ
gs-4060	439	36	tumor	tumor	NOUN
gs-4060	439	37	microenvironments	microenvironment	NOUN
gs-4060	439	38	.	.	PUNCT
gs-4060	440	1	the	the	DET
gs-4060	440	2	logistical	logistical	ADJ
gs-4060	440	3	complexity	complexity	NOUN
gs-4060	440	4	and	and	CCONJ
gs-4060	440	5	exceedingly	exceedingly	ADV
gs-4060	440	6	high	high	ADJ
gs-4060	440	7	cost	cost	NOUN
gs-4060	440	8	of	of	ADP
gs-4060	440	9	these	these	DET
gs-4060	440	10	therapies	therapy	NOUN
gs-4060	440	11	also	also	ADV
gs-4060	440	12	pose	pose	VERB
gs-4060	440	13	substantial	substantial	ADJ
gs-4060	440	14	challenges	challenge	NOUN
gs-4060	440	15	to	to	ADP
gs-4060	440	16	healthcare	healthcare	NOUN
gs-4060	440	17	systems	system	NOUN
gs-4060	440	18	worldwide	worldwide	ADV
gs-4060	440	19	.	.	PUNCT
gs-4060	441	1	future	future	ADJ
gs-4060	441	2	directions	direction	NOUN
gs-4060	441	3	are	be	AUX
gs-4060	441	4	focused	focus	VERB
gs-4060	441	5	on	on	ADP
gs-4060	441	6	next	next	ADJ
gs-4060	441	7	-	-	PUNCT
gs-4060	441	8	generation	generation	NOUN
gs-4060	441	9	innovations	innovation	NOUN
gs-4060	441	10	.	.	PUNCT
gs-4060	442	1	these	these	PRON
gs-4060	442	2	include	include	VERB
gs-4060	442	3	the	the	DET
gs-4060	442	4	development	development	NOUN
gs-4060	442	5	of	of	ADP
gs-4060	442	6	drugs	drug	NOUN
gs-4060	442	7	targeting	target	VERB
gs-4060	442	8	previously	previously	ADV
gs-4060	442	9	"	"	PUNCT
gs-4060	442	10	undruggable	undruggable	ADJ
gs-4060	442	11	"	"	PUNCT
gs-4060	442	12	targets	target	NOUN
gs-4060	442	13	like	like	ADP
gs-4060	442	14	kras	kras	PROPN
gs-4060	442	15	,	,	PUNCT
gs-4060	442	16	the	the	DET
gs-4060	442	17	creation	creation	NOUN
gs-4060	442	18	of	of	ADP
gs-4060	442	19	more	more	ADV
gs-4060	442	20	sophisticated	sophisticated	ADJ
gs-4060	442	21	bispecific	bispecific	NOUN
gs-4060	442	22	t	t	NOUN
gs-4060	442	23	-	-	PUNCT
gs-4060	442	24	cell	cell	NOUN
gs-4060	442	25	engagers	engager	NOUN
gs-4060	442	26	and	and	CCONJ
gs-4060	442	27	next	next	ADJ
gs-4060	442	28	-	-	PUNCT
gs-4060	442	29	generation	generation	NOUN
gs-4060	442	30	car	car	NOUN
gs-4060	442	31	t	t	NOUN
gs-4060	442	32	-	-	PUNCT
gs-4060	442	33	cells	cell	NOUN
gs-4060	442	34	with	with	ADP
gs-4060	442	35	improved	improved	ADJ
gs-4060	442	36	safety	safety	NOUN
gs-4060	442	37	profiles	profile	NOUN
gs-4060	442	38	and	and	CCONJ
gs-4060	442	39	efficacy	efficacy	NOUN
gs-4060	442	40	against	against	ADP
gs-4060	442	41	solid	solid	ADJ
gs-4060	442	42	tumors	tumor	NOUN
gs-4060	442	43	,	,	PUNCT
gs-4060	442	44	and	and	CCONJ
gs-4060	442	45	the	the	DET
gs-4060	442	46	exploration	exploration	NOUN
gs-4060	442	47	of	of	ADP
gs-4060	442	48	novel	novel	ADJ
gs-4060	442	49	immunotherapeutic	immunotherapeutic	ADJ
gs-4060	442	50	targets	target	NOUN
gs-4060	442	51	beyond	beyond	ADP
gs-4060	442	52	pd-1	pd-1	ADV
gs-4060	442	53	and	and	CCONJ
gs-4060	442	54	ctla-4	ctla-4	NOUN
gs-4060	442	55	.	.	PUNCT
gs-4060	443	1	the	the	DET
gs-4060	443	2	journey	journey	NOUN
gs-4060	443	3	of	of	ADP
gs-4060	443	4	discovery	discovery	NOUN
gs-4060	443	5	continues	continue	VERB
gs-4060	443	6	,	,	PUNCT
gs-4060	443	7	driven	drive	VERB
gs-4060	443	8	by	by	ADP
gs-4060	443	9	the	the	DET
gs-4060	443	10	relentless	relentless	ADJ
gs-4060	443	11	pursuit	pursuit	NOUN
gs-4060	443	12	of	of	ADP
gs-4060	443	13	translating	translate	VERB
gs-4060	443	14	scientific	scientific	ADJ
gs-4060	443	15	insight	insight	NOUN
gs-4060	443	16	into	into	ADP
gs-4060	443	17	tangible	tangible	ADJ
gs-4060	443	18	clinical	clinical	ADJ
gs-4060	443	19	benefit	benefit	NOUN
gs-4060	443	20	for	for	ADP
gs-4060	443	21	patients	patient	NOUN
gs-4060	443	22	afflicted	afflict	VERB
gs-4060	443	23	with	with	ADP
gs-4060	443	24	cancer	cancer	NOUN
gs-4060	443	25	.	.	PUNCT
gs-4060	444	1	the	the	DET
gs-4060	444	2	intricacies	intricacy	NOUN
gs-4060	444	3	of	of	ADP
gs-4060	444	4	targeted	target	VERB
gs-4060	444	5	therapy	therapy	NOUN
gs-4060	444	6	:	:	PUNCT
gs-4060	444	7	a	a	DET
gs-4060	444	8	deep	deep	ADJ
gs-4060	444	9	dive	dive	NOUN
gs-4060	444	10	into	into	ADP
gs-4060	444	11	key	key	ADJ
gs-4060	444	12	pathways	pathway	NOUN
gs-4060	444	13	a	a	DET
gs-4060	444	14	more	more	ADV
gs-4060	444	15	granular	granular	ADJ
gs-4060	444	16	examination	examination	NOUN
gs-4060	444	17	of	of	ADP
gs-4060	444	18	specific	specific	ADJ
gs-4060	444	19	targeted	target	VERB
gs-4060	444	20	pathways	pathway	NOUN
gs-4060	444	21	reveals	reveal	VERB
gs-4060	444	22	the	the	DET
gs-4060	444	23	sophistication	sophistication	NOUN
gs-4060	444	24	and	and	CCONJ
gs-4060	444	25	challenges	challenge	NOUN
gs-4060	444	26	of	of	ADP
gs-4060	444	27	modern	modern	ADJ
gs-4060	444	28	cancer	cancer	NOUN
gs-4060	444	29	drug	drug	NOUN
gs-4060	444	30	development	development	NOUN
gs-4060	444	31	.	.	PUNCT
gs-4060	445	1	the	the	DET
gs-4060	445	2	epidermal	epidermal	ADJ
gs-4060	445	3	growth	growth	NOUN
gs-4060	445	4	factor	factor	NOUN
gs-4060	445	5	receptor	receptor	NOUN
gs-4060	445	6	pathway	pathway	NOUN
gs-4060	445	7	serves	serve	VERB
gs-4060	445	8	as	as	ADP
gs-4060	445	9	a	a	DET
gs-4060	445	10	paradigmatic	paradigmatic	ADJ
gs-4060	445	11	example	example	NOUN
gs-4060	445	12	.	.	PUNCT
gs-4060	446	1	first	first	ADJ
gs-4060	446	2	-	-	PUNCT
gs-4060	446	3	generation	generation	NOUN
gs-4060	446	4	egfr	egfr	ADJ
gs-4060	446	5	tyrosine	tyrosine	PROPN
gs-4060	446	6	kinase	kinase	PROPN
gs-4060	446	7	inhibitors	inhibitor	NOUN
gs-4060	446	8	,	,	PUNCT
gs-4060	446	9	such	such	ADJ
gs-4060	446	10	as	as	ADP
gs-4060	446	11	erlotinib	erlotinib	NOUN
gs-4060	446	12	and	and	CCONJ
gs-4060	446	13	gefitinib	gefitinib	NOUN
gs-4060	446	14	,	,	PUNCT
gs-4060	446	15	demonstrated	demonstrate	VERB
gs-4060	446	16	remarkable	remarkable	ADJ
gs-4060	446	17	efficacy	efficacy	NOUN
gs-4060	446	18	in	in	ADP
gs-4060	446	19	non	non	ADJ
gs-4060	446	20	-	-	ADJ
gs-4060	446	21	small	small	ADJ
gs-4060	446	22	cell	cell	NOUN
gs-4060	446	23	lung	lung	NOUN
gs-4060	446	24	cancer	cancer	NOUN
gs-4060	446	25	harboring	harboring	NOUN
gs-4060	446	26	activating	activate	VERB
gs-4060	446	27	egfr	egfr	ADJ
gs-4060	446	28	mutations	mutation	NOUN
gs-4060	446	29	.	.	PUNCT
gs-4060	447	1	however	however	ADV
gs-4060	447	2	,	,	PUNCT
gs-4060	447	3	their	their	PRON
gs-4060	447	4	clinical	clinical	ADJ
gs-4060	447	5	utility	utility	NOUN
gs-4060	447	6	was	be	AUX
gs-4060	447	7	inevitably	inevitably	ADV
gs-4060	447	8	curtailed	curtail	VERB
gs-4060	447	9	by	by	ADP
gs-4060	447	10	the	the	DET
gs-4060	447	11	emergence	emergence	NOUN
gs-4060	447	12	of	of	ADP
gs-4060	447	13	resistance	resistance	NOUN
gs-4060	447	14	,	,	PUNCT
gs-4060	447	15	most	most	ADV
gs-4060	447	16	commonly	commonly	ADV
gs-4060	447	17	through	through	ADP
gs-4060	447	18	the	the	DET
gs-4060	447	19	acquisition	acquisition	NOUN
gs-4060	447	20	of	of	ADP
gs-4060	447	21	a	a	DET
gs-4060	447	22	secondary	secondary	ADJ
gs-4060	447	23	t790	t790	NUM
gs-4060	447	24	m	m	NOUN
gs-4060	447	25	mutation	mutation	NOUN
gs-4060	447	26	within	within	ADP
gs-4060	447	27	the	the	DET
gs-4060	447	28	atp	atp	NOUN
gs-4060	447	29	-	-	PUNCT
gs-4060	447	30	binding	bind	VERB
gs-4060	447	31	pocket	pocket	NOUN
gs-4060	447	32	.	.	PUNCT
gs-4060	448	1	this	this	DET
gs-4060	448	2	knowledge	knowledge	NOUN
gs-4060	448	3	directly	directly	ADV
gs-4060	448	4	fueled	fuel	VERB
gs-4060	448	5	the	the	DET
gs-4060	448	6	development	development	NOUN
gs-4060	448	7	of	of	ADP
gs-4060	448	8	second	second	ADJ
gs-4060	448	9	-	-	PUNCT
gs-4060	448	10	generation	generation	NOUN
gs-4060	448	11	irreversible	irreversible	ADJ
gs-4060	448	12	inhibitors	inhibitor	NOUN
gs-4060	448	13	like	like	ADP
gs-4060	448	14	afatinib	afatinib	NOUN
gs-4060	448	15	,	,	PUNCT
gs-4060	448	16	designed	design	VERB
gs-4060	448	17	to	to	PART
gs-4060	448	18	covalently	covalently	ADV
gs-4060	448	19	bind	bind	VERB
gs-4060	448	20	the	the	DET
gs-4060	448	21	kinase	kinase	NOUN
gs-4060	448	22	domain	domain	NOUN
gs-4060	448	23	,	,	PUNCT
gs-4060	448	24	and	and	CCONJ
gs-4060	448	25	subsequently	subsequently	ADV
gs-4060	448	26	,	,	PUNCT
gs-4060	448	27	third	third	ADJ
gs-4060	448	28	-	-	PUNCT
gs-4060	448	29	generation	generation	NOUN
gs-4060	448	30	osimertinib	osimertinib	NOUN
gs-4060	448	31	,	,	PUNCT
gs-4060	448	32	which	which	PRON
gs-4060	448	33	is	be	AUX
gs-4060	448	34	specifically	specifically	ADV
gs-4060	448	35	optimized	optimize	VERB
gs-4060	448	36	to	to	PART
gs-4060	448	37	target	target	VERB
gs-4060	448	38	the	the	DET
gs-4060	448	39	t790	t790	NUM
gs-4060	448	40	m	m	NOUN
gs-4060	448	41	mutant	mutant	ADJ
gs-4060	448	42	receptor	receptor	NOUN
gs-4060	448	43	while	while	SCONJ
gs-4060	448	44	sparing	spare	VERB
gs-4060	448	45	wild	wild	ADJ
gs-4060	448	46	-	-	PUNCT
gs-4060	448	47	type	type	NOUN
gs-4060	448	48	egfr	egfr	NOUN
gs-4060	448	49	,	,	PUNCT
gs-4060	448	50	thereby	thereby	ADV
gs-4060	448	51	mitigating	mitigate	VERB
gs-4060	448	52	dose	dose	NOUN
gs-4060	448	53	-	-	PUNCT
gs-4060	448	54	limiting	limit	VERB
gs-4060	448	55	toxicities	toxicity	NOUN
gs-4060	448	56	like	like	ADP
gs-4060	448	57	skin	skin	NOUN
gs-4060	448	58	rash	rash	NOUN
gs-4060	448	59	.	.	PUNCT
gs-4060	449	1	this	this	DET
gs-4060	449	2	iterative	iterative	NOUN
gs-4060	449	3	process	process	NOUN
gs-4060	449	4	—	—	PUNCT
gs-4060	449	5	from	from	ADP
gs-4060	449	6	initial	initial	ADJ
gs-4060	449	7	efficacy	efficacy	NOUN
gs-4060	449	8	to	to	ADP
gs-4060	449	9	understanding	understand	VERB
gs-4060	449	10	resistance	resistance	NOUN
gs-4060	449	11	and	and	CCONJ
gs-4060	449	12	engineering	engineer	VERB
gs-4060	449	13	a	a	DET
gs-4060	449	14	superior	superior	ADJ
gs-4060	449	15	solution	solution	NOUN
gs-4060	449	16	—	—	PUNCT
gs-4060	449	17	epitomizes	epitomize	VERB
gs-4060	449	18	the	the	DET
gs-4060	449	19	dynamic	dynamic	ADJ
gs-4060	449	20	nature	nature	NOUN
gs-4060	449	21	of	of	ADP
gs-4060	449	22	oncology	oncology	NOUN
gs-4060	449	23	drug	drug	NOUN
gs-4060	449	24	development	development	NOUN
gs-4060	449	25	in	in	ADP
gs-4060	449	26	the	the	DET
gs-4060	449	27	targeted	target	VERB
gs-4060	449	28	therapy	therapy	NOUN
gs-4060	449	29	era	era	NOUN
gs-4060	449	30	.	.	PUNCT
gs-4060	450	1	georgian	georgian	NOUN
gs-4060	450	2	scientists/	scientists/	NUM
gs-4060	450	3	.	.	PUNCT
gs-4060	451	1	7	7	NUM
gs-4060	451	2	n	n	PRON
gs-4060	451	3	3	3	NUM
gs-4060	451	4	,	,	PUNCT
gs-4060	451	5	2025	2025	NUM
gs-4060	451	6	590	590	NUM
gs-4060	451	7	another	another	DET
gs-4060	451	8	illustrative	illustrative	ADJ
gs-4060	451	9	pathway	pathway	NOUN
gs-4060	451	10	is	be	AUX
gs-4060	451	11	the	the	DET
gs-4060	451	12	mitogen	mitogen	NOUN
gs-4060	451	13	-	-	PUNCT
gs-4060	451	14	activated	activate	VERB
gs-4060	451	15	protein	protein	NOUN
gs-4060	451	16	kinase	kinase	NOUN
gs-4060	451	17	pathway	pathway	NOUN
gs-4060	451	18	,	,	PUNCT
gs-4060	451	19	a	a	DET
gs-4060	451	20	key	key	ADJ
gs-4060	451	21	driver	driver	NOUN
gs-4060	451	22	in	in	ADP
gs-4060	451	23	melanoma	melanoma	NOUN
gs-4060	451	24	and	and	CCONJ
gs-4060	451	25	other	other	ADJ
gs-4060	451	26	cancers	cancer	NOUN
gs-4060	451	27	.	.	PUNCT
gs-4060	452	1	braf	braf	NOUN
gs-4060	452	2	inhibitors	inhibitor	NOUN
gs-4060	452	3	,	,	PUNCT
gs-4060	452	4	such	such	ADJ
gs-4060	452	5	as	as	ADP
gs-4060	452	6	vemurafenib	vemurafenib	NOUN
gs-4060	452	7	and	and	CCONJ
gs-4060	452	8	dabrafenib	dabrafenib	NOUN
gs-4060	452	9	,	,	PUNCT
gs-4060	452	10	produce	produce	VERB
gs-4060	452	11	dramatic	dramatic	ADJ
gs-4060	452	12	tumor	tumor	NOUN
gs-4060	452	13	regressions	regression	NOUN
gs-4060	452	14	in	in	ADP
gs-4060	452	15	patients	patient	NOUN
gs-4060	452	16	whose	whose	DET
gs-4060	452	17	melanomas	melanomas	NOUN
gs-4060	452	18	harbor	harbor	VERB
gs-4060	452	19	the	the	DET
gs-4060	452	20	braf	braf	NOUN
gs-4060	452	21	v600e	v600e	NOUN
gs-4060	452	22	mutation	mutation	NOUN
gs-4060	452	23	.	.	PUNCT
gs-4060	453	1	however	however	ADV
gs-4060	453	2	,	,	PUNCT
gs-4060	453	3	the	the	DET
gs-4060	453	4	response	response	NOUN
gs-4060	453	5	is	be	AUX
gs-4060	453	6	frequently	frequently	ADV
gs-4060	453	7	short	short	ADV
gs-4060	453	8	-	-	PUNCT
gs-4060	453	9	lived	live	VERB
gs-4060	453	10	,	,	PUNCT
gs-4060	453	11	as	as	SCONJ
gs-4060	453	12	tumors	tumor	NOUN
gs-4060	453	13	rapidly	rapidly	ADV
gs-4060	453	14	activate	activate	VERB
gs-4060	453	15	bypass	bypass	NOUN
gs-4060	453	16	tracks	track	NOUN
gs-4060	453	17	,	,	PUNCT
gs-4060	453	18	often	often	ADV
gs-4060	453	19	through	through	ADP
gs-4060	453	20	upstream	upstream	ADJ
gs-4060	453	21	or	or	CCONJ
gs-4060	453	22	parallel	parallel	ADJ
gs-4060	453	23	signaling	signal	VERB
gs-4060	453	24	nodes	node	NOUN
gs-4060	453	25	.	.	PUNCT
gs-4060	454	1	this	this	DET
gs-4060	454	2	understanding	understanding	NOUN
gs-4060	454	3	led	lead	VERB
gs-4060	454	4	to	to	ADP
gs-4060	454	5	the	the	DET
gs-4060	454	6	rational	rational	ADJ
gs-4060	454	7	combination	combination	NOUN
gs-4060	454	8	of	of	ADP
gs-4060	454	9	braf	braf	NOUN
gs-4060	454	10	inhibitors	inhibitor	NOUN
gs-4060	454	11	with	with	ADP
gs-4060	454	12	mek	mek	PROPN
gs-4060	454	13	inhibitors	inhibitor	NOUN
gs-4060	454	14	,	,	PUNCT
gs-4060	454	15	such	such	ADJ
gs-4060	454	16	as	as	ADP
gs-4060	454	17	cobimetinib	cobimetinib	NOUN
gs-4060	454	18	or	or	CCONJ
gs-4060	454	19	trametinib	trametinib	NOUN
gs-4060	454	20	.	.	PUNCT
gs-4060	455	1	this	this	DET
gs-4060	455	2	dual	dual	ADJ
gs-4060	455	3	-	-	PUNCT
gs-4060	455	4	pathway	pathway	NOUN
gs-4060	455	5	blockade	blockade	NOUN
gs-4060	455	6	not	not	PART
gs-4060	455	7	only	only	ADV
gs-4060	455	8	enhances	enhance	VERB
gs-4060	455	9	the	the	DET
gs-4060	455	10	depth	depth	NOUN
gs-4060	455	11	and	and	CCONJ
gs-4060	455	12	duration	duration	NOUN
gs-4060	455	13	of	of	ADP
gs-4060	455	14	response	response	NOUN
gs-4060	455	15	but	but	CCONJ
gs-4060	455	16	also	also	ADV
gs-4060	455	17	paradoxically	paradoxically	ADV
gs-4060	455	18	reduces	reduce	VERB
gs-4060	455	19	the	the	DET
gs-4060	455	20	cutaneous	cutaneous	ADJ
gs-4060	455	21	toxicities	toxicity	NOUN
gs-4060	455	22	associated	associate	VERB
gs-4060	455	23	with	with	ADP
gs-4060	455	24	braf	braf	NOUN
gs-4060	455	25	inhibition	inhibition	NOUN
gs-4060	455	26	alone	alone	ADV
gs-4060	455	27	,	,	PUNCT
gs-4060	455	28	such	such	ADJ
gs-4060	455	29	as	as	ADP
gs-4060	455	30	verrucous	verrucous	ADJ
gs-4060	455	31	keratoses	keratose	NOUN
gs-4060	455	32	and	and	CCONJ
gs-4060	455	33	squamous	squamous	ADJ
gs-4060	455	34	cell	cell	NOUN
gs-4060	455	35	carcinomas	carcinoma	NOUN
gs-4060	455	36	,	,	PUNCT
gs-4060	455	37	which	which	PRON
gs-4060	455	38	are	be	AUX
gs-4060	455	39	mediated	mediate	VERB
gs-4060	455	40	through	through	ADP
gs-4060	455	41	paradoxical	paradoxical	ADJ
gs-4060	455	42	mapk	mapk	NOUN
gs-4060	455	43	pathway	pathway	NOUN
gs-4060	455	44	activation	activation	NOUN
gs-4060	455	45	in	in	ADP
gs-4060	455	46	wild	wild	ADJ
gs-4060	455	47	-	-	PUNCT
gs-4060	455	48	type	type	NOUN
gs-4060	455	49	cells	cell	NOUN
gs-4060	455	50	.	.	PUNCT
gs-4060	456	1	this	this	DET
gs-4060	456	2	example	example	NOUN
gs-4060	456	3	underscores	underscore	VERB
gs-4060	456	4	a	a	DET
gs-4060	456	5	critical	critical	ADJ
gs-4060	456	6	principle	principle	NOUN
gs-4060	456	7	:	:	PUNCT
gs-4060	456	8	rational	rational	ADJ
gs-4060	456	9	drug	drug	NOUN
gs-4060	456	10	combinations	combination	NOUN
gs-4060	456	11	,	,	PUNCT
gs-4060	456	12	informed	inform	VERB
gs-4060	456	13	by	by	ADP
gs-4060	456	14	a	a	DET
gs-4060	456	15	deep	deep	ADJ
gs-4060	456	16	understanding	understanding	NOUN
gs-4060	456	17	of	of	ADP
gs-4060	456	18	signaling	signal	VERB
gs-4060	456	19	network	network	NOUN
gs-4060	456	20	feedback	feedback	NOUN
gs-4060	456	21	loops	loop	NOUN
gs-4060	456	22	,	,	PUNCT
gs-4060	456	23	are	be	AUX
gs-4060	456	24	essential	essential	ADJ
gs-4060	456	25	to	to	PART
gs-4060	456	26	overcome	overcome	VERB
gs-4060	456	27	the	the	DET
gs-4060	456	28	adaptive	adaptive	ADJ
gs-4060	456	29	resilience	resilience	NOUN
gs-4060	456	30	of	of	ADP
gs-4060	456	31	cancer	cancer	NOUN
gs-4060	456	32	cells	cell	NOUN
gs-4060	456	33	.	.	PUNCT
gs-4060	457	1	the	the	DET
gs-4060	457	2	development	development	NOUN
gs-4060	457	3	of	of	ADP
gs-4060	457	4	cyclin	cyclin	NOUN
gs-4060	457	5	-	-	PUNCT
gs-4060	457	6	dependent	dependent	ADJ
gs-4060	457	7	kinase	kinase	NOUN
gs-4060	457	8	4/6	4/6	NUM
gs-4060	457	9	inhibitors	inhibitor	NOUN
gs-4060	457	10	for	for	ADP
gs-4060	457	11	hormone	hormone	NOUN
gs-4060	457	12	receptor	receptor	NOUN
gs-4060	457	13	-	-	PUNCT
gs-4060	457	14	positive	positive	ADJ
gs-4060	457	15	breast	breast	NOUN
gs-4060	457	16	cancer	cancer	NOUN
gs-4060	457	17	demonstrates	demonstrate	VERB
gs-4060	457	18	the	the	DET
gs-4060	457	19	successful	successful	ADJ
gs-4060	457	20	targeting	targeting	NOUN
gs-4060	457	21	of	of	ADP
gs-4060	457	22	the	the	DET
gs-4060	457	23	cell	cell	NOUN
gs-4060	457	24	cycle	cycle	NOUN
gs-4060	457	25	machinery	machinery	NOUN
gs-4060	457	26	.	.	PUNCT
gs-4060	458	1	drugs	drug	NOUN
gs-4060	458	2	like	like	ADP
gs-4060	458	3	palbociclib	palbociclib	NOUN
gs-4060	458	4	,	,	PUNCT
gs-4060	458	5	ribociclib	ribociclib	NOUN
gs-4060	458	6	,	,	PUNCT
gs-4060	458	7	and	and	CCONJ
gs-4060	458	8	abemaciclib	abemaciclib	NOUN
gs-4060	458	9	arrest	arrest	VERB
gs-4060	458	10	the	the	DET
gs-4060	458	11	cell	cell	NOUN
gs-4060	458	12	cycle	cycle	NOUN
gs-4060	458	13	in	in	ADP
gs-4060	458	14	the	the	DET
gs-4060	458	15	g1	g1	PROPN
gs-4060	458	16	phase	phase	NOUN
gs-4060	458	17	by	by	ADP
gs-4060	458	18	inhibiting	inhibit	VERB
gs-4060	458	19	the	the	DET
gs-4060	458	20	phosphorylation	phosphorylation	NOUN
gs-4060	458	21	of	of	ADP
gs-4060	458	22	the	the	DET
gs-4060	458	23	retinoblastoma	retinoblastoma	NOUN
gs-4060	458	24	protein	protein	NOUN
gs-4060	458	25	.	.	PUNCT
gs-4060	459	1	their	their	PRON
gs-4060	459	2	clinical	clinical	ADJ
gs-4060	459	3	success	success	NOUN
gs-4060	459	4	is	be	AUX
gs-4060	459	5	not	not	PART
gs-4060	459	6	as	as	ADP
gs-4060	459	7	monotherapies	monotherapie	NOUN
gs-4060	459	8	but	but	CCONJ
gs-4060	459	9	in	in	ADP
gs-4060	459	10	combination	combination	NOUN
gs-4060	459	11	with	with	ADP
gs-4060	459	12	endocrine	endocrine	NOUN
gs-4060	459	13	therapy	therapy	NOUN
gs-4060	459	14	,	,	PUNCT
gs-4060	459	15	where	where	SCONJ
gs-4060	459	16	they	they	PRON
gs-4060	459	17	profoundly	profoundly	ADV
gs-4060	459	18	delay	delay	VERB
gs-4060	459	19	disease	disease	NOUN
gs-4060	459	20	progression	progression	NOUN
gs-4060	459	21	.	.	PUNCT
gs-4060	460	1	the	the	DET
gs-4060	460	2	pharmacological	pharmacological	ADJ
gs-4060	460	3	differences	difference	NOUN
gs-4060	460	4	between	between	ADP
gs-4060	460	5	these	these	DET
gs-4060	460	6	agents	agent	NOUN
gs-4060	460	7	,	,	PUNCT
gs-4060	460	8	such	such	ADJ
gs-4060	460	9	as	as	ADP
gs-4060	460	10	abemaciclib	abemaciclib	PROPN
gs-4060	460	11	’s	’s	PART
gs-4060	460	12	greater	great	ADJ
gs-4060	460	13	single	single	ADJ
gs-4060	460	14	-	-	PUNCT
gs-4060	460	15	agent	agent	NOUN
gs-4060	460	16	activity	activity	NOUN
gs-4060	460	17	and	and	CCONJ
gs-4060	460	18	distinct	distinct	ADJ
gs-4060	460	19	toxicity	toxicity	NOUN
gs-4060	460	20	profile	profile	NOUN
gs-4060	460	21	(	(	PUNCT
gs-4060	460	22	higher	high	ADJ
gs-4060	460	23	incidence	incidence	NOUN
gs-4060	460	24	of	of	ADP
gs-4060	460	25	diarrhea	diarrhea	NOUN
gs-4060	460	26	,	,	PUNCT
gs-4060	460	27	lower	low	ADJ
gs-4060	460	28	incidence	incidence	NOUN
gs-4060	460	29	of	of	ADP
gs-4060	460	30	neutropenia	neutropenia	NOUN
gs-4060	460	31	)	)	PUNCT
gs-4060	460	32	,	,	PUNCT
gs-4060	460	33	highlight	highlight	VERB
gs-4060	460	34	how	how	SCONJ
gs-4060	460	35	subtle	subtle	ADJ
gs-4060	460	36	variations	variation	NOUN
gs-4060	460	37	in	in	ADP
gs-4060	460	38	drug	drug	NOUN
gs-4060	460	39	selectivity	selectivity	NOUN
gs-4060	460	40	and	and	CCONJ
gs-4060	460	41	pharmacokinetics	pharmacokinetic	NOUN
gs-4060	460	42	can	can	AUX
gs-4060	460	43	lead	lead	VERB
gs-4060	460	44	to	to	ADP
gs-4060	460	45	meaningful	meaningful	ADJ
gs-4060	460	46	clinical	clinical	ADJ
gs-4060	460	47	differences	difference	NOUN
gs-4060	460	48	,	,	PUNCT
gs-4060	460	49	offering	offer	VERB
gs-4060	460	50	clinicians	clinician	NOUN
gs-4060	460	51	choices	choice	NOUN
gs-4060	460	52	to	to	PART
gs-4060	460	53	tailor	tailor	NOUN
gs-4060	460	54	therapy	therapy	NOUN
gs-4060	460	55	based	base	VERB
gs-4060	460	56	on	on	ADP
gs-4060	460	57	individual	individual	ADJ
gs-4060	460	58	patient	patient	ADJ
gs-4060	460	59	profiles	profile	NOUN
gs-4060	460	60	and	and	CCONJ
gs-4060	460	61	comorbidities	comorbiditie	NOUN
gs-4060	460	62	.	.	PUNCT
gs-4060	461	1	the	the	DET
gs-4060	461	2	evolving	evolve	VERB
gs-4060	461	3	landscape	landscape	NOUN
gs-4060	461	4	of	of	ADP
gs-4060	461	5	immunotherapy	immunotherapy	NOUN
gs-4060	461	6	:	:	PUNCT
gs-4060	461	7	beyond	beyond	ADP
gs-4060	461	8	checkpoint	checkpoint	NOUN
gs-4060	461	9	inhibition	inhibition	NOUN
gs-4060	461	10	while	while	SCONJ
gs-4060	461	11	immune	immune	ADJ
gs-4060	461	12	checkpoint	checkpoint	NOUN
gs-4060	461	13	blockade	blockade	NOUN
gs-4060	461	14	has	have	AUX
gs-4060	461	15	rightfully	rightfully	ADV
gs-4060	461	16	garnered	garner	VERB
gs-4060	461	17	immense	immense	ADJ
gs-4060	461	18	attention	attention	NOUN
gs-4060	461	19	,	,	PUNCT
gs-4060	461	20	the	the	DET
gs-4060	461	21	field	field	NOUN
gs-4060	461	22	of	of	ADP
gs-4060	461	23	cancer	cancer	NOUN
gs-4060	461	24	immunotherapy	immunotherapy	NOUN
gs-4060	461	25	is	be	AUX
gs-4060	461	26	far	far	ADV
gs-4060	461	27	broader	broad	ADJ
gs-4060	461	28	.	.	PUNCT
gs-4060	462	1	adoptive	adoptive	ADJ
gs-4060	462	2	cell	cell	NOUN
gs-4060	462	3	therapy	therapy	NOUN
gs-4060	462	4	,	,	PUNCT
gs-4060	462	5	particularly	particularly	ADV
gs-4060	462	6	car	car	NOUN
gs-4060	462	7	t	t	NOUN
gs-4060	462	8	-	-	PUNCT
gs-4060	462	9	cell	cell	NOUN
gs-4060	462	10	therapy	therapy	NOUN
gs-4060	462	11	,	,	PUNCT
gs-4060	462	12	represents	represent	VERB
gs-4060	462	13	a	a	DET
gs-4060	462	14	pinnacle	pinnacle	NOUN
gs-4060	462	15	of	of	ADP
gs-4060	462	16	personalized	personalized	ADJ
gs-4060	462	17	medicine	medicine	NOUN
gs-4060	462	18	.	.	PUNCT
gs-4060	463	1	the	the	DET
gs-4060	463	2	process	process	NOUN
gs-4060	463	3	involves	involve	VERB
gs-4060	463	4	leukapheresis	leukapheresis	NOUN
gs-4060	463	5	,	,	PUNCT
gs-4060	463	6	genetic	genetic	ADJ
gs-4060	463	7	modification	modification	NOUN
gs-4060	463	8	of	of	ADP
gs-4060	463	9	a	a	DET
gs-4060	463	10	patient	patient	NOUN
gs-4060	463	11	’s	’s	PART
gs-4060	463	12	t	t	PROPN
gs-4060	463	13	-	-	PUNCT
gs-4060	463	14	cells	cell	NOUN
gs-4060	463	15	ex	ex	X
gs-4060	463	16	vivo	vivo	VERB
gs-4060	463	17	to	to	PART
gs-4060	463	18	express	express	VERB
gs-4060	463	19	a	a	DET
gs-4060	463	20	synthetic	synthetic	ADJ
gs-4060	463	21	receptor	receptor	NOUN
gs-4060	463	22	targeting	target	VERB
gs-4060	463	23	an	an	DET
gs-4060	463	24	antigen	antigen	NOUN
gs-4060	463	25	like	like	ADP
gs-4060	463	26	cd19	cd19	PROPN
gs-4060	463	27	or	or	CCONJ
gs-4060	463	28	bcma	bcma	NOUN
gs-4060	463	29	,	,	PUNCT
gs-4060	463	30	lymphodepleting	lymphodeplete	VERB
gs-4060	463	31	chemotherapy	chemotherapy	NOUN
gs-4060	463	32	,	,	PUNCT
gs-4060	463	33	and	and	CCONJ
gs-4060	463	34	subsequent	subsequent	ADJ
gs-4060	463	35	reinfusion	reinfusion	NOUN
gs-4060	463	36	of	of	ADP
gs-4060	463	37	the	the	DET
gs-4060	463	38	engineered	engineer	VERB
gs-4060	463	39	cells	cell	NOUN
gs-4060	463	40	.	.	PUNCT
gs-4060	464	1	the	the	DET
gs-4060	464	2	results	result	NOUN
gs-4060	464	3	in	in	ADP
gs-4060	464	4	certain	certain	ADJ
gs-4060	464	5	b	b	NOUN
gs-4060	464	6	-	-	PUNCT
gs-4060	464	7	cell	cell	NOUN
gs-4060	464	8	malignancies	malignancy	NOUN
gs-4060	464	9	are	be	AUX
gs-4060	464	10	unprecedented	unprecedented	ADJ
gs-4060	464	11	,	,	PUNCT
gs-4060	464	12	with	with	ADP
gs-4060	464	13	high	high	ADJ
gs-4060	464	14	rates	rate	NOUN
gs-4060	464	15	of	of	ADP
gs-4060	464	16	complete	complete	ADJ
gs-4060	464	17	and	and	CCONJ
gs-4060	464	18	durable	durable	ADJ
gs-4060	464	19	remission	remission	NOUN
gs-4060	464	20	in	in	ADP
gs-4060	464	21	patients	patient	NOUN
gs-4060	464	22	with	with	ADP
gs-4060	464	23	otherwise	otherwise	ADV
gs-4060	464	24	refractory	refractory	NOUN
gs-4060	464	25	disease	disease	NOUN
gs-4060	464	26	.	.	PUNCT
gs-4060	465	1	however	however	ADV
gs-4060	465	2	,	,	PUNCT
gs-4060	465	3	the	the	DET
gs-4060	465	4	challenges	challenge	NOUN
gs-4060	465	5	are	be	AUX
gs-4060	465	6	significant	significant	ADJ
gs-4060	465	7	.	.	PUNCT
gs-4060	466	1	the	the	DET
gs-4060	466	2	products	product	NOUN
gs-4060	466	3	are	be	AUX
gs-4060	466	4	complex	complex	ADJ
gs-4060	466	5	and	and	CCONJ
gs-4060	466	6	costly	costly	ADJ
gs-4060	466	7	to	to	PART
gs-4060	466	8	manufacture	manufacture	VERB
gs-4060	466	9	,	,	PUNCT
gs-4060	466	10	leading	lead	VERB
gs-4060	466	11	to	to	ADP
gs-4060	466	12	logistical	logistical	ADJ
gs-4060	466	13	hurdles	hurdle	NOUN
gs-4060	466	14	and	and	CCONJ
gs-4060	466	15	delays	delay	NOUN
gs-4060	466	16	.	.	PUNCT
gs-4060	467	1	the	the	DET
gs-4060	467	2	toxicities	toxicity	NOUN
gs-4060	467	3	,	,	PUNCT
gs-4060	467	4	crs	crs	PROPN
gs-4060	467	5	and	and	CCONJ
gs-4060	467	6	icans	ican	NOUN
gs-4060	467	7	,	,	PUNCT
gs-4060	467	8	require	require	VERB
gs-4060	467	9	management	management	NOUN
gs-4060	467	10	in	in	ADP
gs-4060	467	11	specialized	specialized	ADJ
gs-4060	467	12	centers	center	NOUN
gs-4060	467	13	.	.	PUNCT
gs-4060	468	1	furthermore	furthermore	ADV
gs-4060	468	2	,	,	PUNCT
gs-4060	468	3	the	the	DET
gs-4060	468	4	efficacy	efficacy	NOUN
gs-4060	468	5	of	of	ADP
gs-4060	468	6	car	car	NOUN
gs-4060	468	7	t	t	NOUN
gs-4060	468	8	-	-	PUNCT
gs-4060	468	9	cells	cell	NOUN
gs-4060	468	10	in	in	ADP
gs-4060	468	11	solid	solid	ADJ
gs-4060	468	12	tumors	tumor	NOUN
gs-4060	468	13	has	have	AUX
gs-4060	468	14	been	be	AUX
gs-4060	468	15	limited	limit	VERB
gs-4060	468	16	,	,	PUNCT
gs-4060	468	17	due	due	ADP
gs-4060	468	18	to	to	ADP
gs-4060	468	19	factors	factor	NOUN
gs-4060	468	20	such	such	ADJ
gs-4060	468	21	as	as	ADP
gs-4060	468	22	tumor	tumor	NOUN
gs-4060	468	23	antigen	antigen	NOUN
gs-4060	468	24	heterogeneity	heterogeneity	NOUN
gs-4060	468	25	,	,	PUNCT
gs-4060	468	26	a	a	DET
gs-4060	468	27	suppressive	suppressive	ADJ
gs-4060	468	28	tumor	tumor	NOUN
gs-4060	468	29	microenvironment	microenvironment	NOUN
gs-4060	468	30	,	,	PUNCT
gs-4060	468	31	and	and	CCONJ
gs-4060	468	32	inadequate	inadequate	ADJ
gs-4060	468	33	t	t	NOUN
gs-4060	468	34	-	-	PUNCT
gs-4060	468	35	cell	cell	NOUN
gs-4060	468	36	trafficking	trafficking	NOUN
gs-4060	468	37	and	and	CCONJ
gs-4060	468	38	persistence	persistence	NOUN
gs-4060	468	39	.	.	PUNCT
gs-4060	469	1	next	next	ADJ
gs-4060	469	2	-	-	PUNCT
gs-4060	469	3	generation	generation	NOUN
gs-4060	469	4	strategies	strategy	NOUN
gs-4060	469	5	are	be	AUX
gs-4060	469	6	focusing	focus	VERB
gs-4060	469	7	on	on	ADP
gs-4060	469	8	arming	arm	VERB
gs-4060	469	9	car	car	NOUN
gs-4060	469	10	t	t	NOUN
gs-4060	469	11	-	-	PUNCT
gs-4060	469	12	cells	cell	NOUN
gs-4060	469	13	with	with	ADP
gs-4060	469	14	capabilities	capability	NOUN
gs-4060	469	15	to	to	PART
gs-4060	469	16	overcome	overcome	VERB
gs-4060	469	17	this	this	DET
gs-4060	469	18	immunosuppression	immunosuppression	NOUN
gs-4060	469	19	,	,	PUNCT
gs-4060	469	20	such	such	ADJ
gs-4060	469	21	as	as	ADP
gs-4060	469	22	secreting	secrete	VERB
gs-4060	469	23	cytokines	cytokine	NOUN
gs-4060	469	24	or	or	CCONJ
gs-4060	469	25	including	include	VERB
gs-4060	469	26	safety	safety	NOUN
gs-4060	469	27	switches	switch	NOUN
gs-4060	469	28	to	to	PART
gs-4060	469	29	mitigate	mitigate	VERB
gs-4060	469	30	toxicity	toxicity	NOUN
gs-4060	469	31	.	.	PUNCT
gs-4060	470	1	antibody	antibody	NOUN
gs-4060	470	2	-	-	PUNCT
gs-4060	470	3	drug	drug	NOUN
gs-4060	470	4	conjugates	conjugate	NOUN
gs-4060	470	5	represent	represent	VERB
gs-4060	470	6	a	a	DET
gs-4060	470	7	masterclass	masterclass	NOUN
gs-4060	470	8	in	in	ADP
gs-4060	470	9	leveraging	leverage	VERB
gs-4060	470	10	the	the	DET
gs-4060	470	11	specificity	specificity	NOUN
gs-4060	470	12	of	of	ADP
gs-4060	470	13	antibodies	antibody	NOUN
gs-4060	470	14	to	to	PART
gs-4060	470	15	deliver	deliver	VERB
gs-4060	470	16	potent	potent	ADJ
gs-4060	470	17	cytotoxicity	cytotoxicity	NOUN
gs-4060	470	18	.	.	PUNCT
gs-4060	471	1	the	the	DET
gs-4060	471	2	therapeutic	therapeutic	ADJ
gs-4060	471	3	index	index	NOUN
gs-4060	471	4	of	of	ADP
gs-4060	471	5	an	an	DET
gs-4060	471	6	adc	adc	NOUN
gs-4060	471	7	is	be	AUX
gs-4060	471	8	a	a	DET
gs-4060	471	9	delicate	delicate	ADJ
gs-4060	471	10	balance	balance	NOUN
gs-4060	471	11	determined	determine	VERB
gs-4060	471	12	by	by	ADP
gs-4060	471	13	three	three	NUM
gs-4060	471	14	components	component	NOUN
gs-4060	471	15	:	:	PUNCT
gs-4060	471	16	the	the	DET
gs-4060	471	17	antibody	antibody	NOUN
gs-4060	471	18	(	(	PUNCT
gs-4060	471	19	determining	determine	VERB
gs-4060	471	20	targeting	target	VERB
gs-4060	471	21	specificity	specificity	NOUN
gs-4060	471	22	)	)	PUNCT
gs-4060	471	23	,	,	PUNCT
gs-4060	471	24	the	the	DET
gs-4060	471	25	linker	linker	NOUN
gs-4060	471	26	(	(	PUNCT
gs-4060	471	27	determining	determine	VERB
gs-4060	471	28	georgian	georgian	PROPN
gs-4060	471	29	scientists/	scientists/	NUM
gs-4060	471	30	.	.	PUNCT
gs-4060	472	1	7	7	NUM
gs-4060	472	2	n	n	PRON
gs-4060	472	3	3	3	NUM
gs-4060	472	4	,	,	PUNCT
gs-4060	472	5	2025	2025	NUM
gs-4060	472	6	591	591	NUM
gs-4060	472	7	stability	stability	NOUN
gs-4060	472	8	in	in	ADP
gs-4060	472	9	circulation	circulation	NOUN
gs-4060	472	10	and	and	CCONJ
gs-4060	472	11	cleavage	cleavage	NOUN
gs-4060	472	12	efficiency	efficiency	NOUN
gs-4060	472	13	in	in	ADP
gs-4060	472	14	the	the	DET
gs-4060	472	15	target	target	NOUN
gs-4060	472	16	cell	cell	NOUN
gs-4060	472	17	)	)	PUNCT
gs-4060	472	18	,	,	PUNCT
gs-4060	472	19	and	and	CCONJ
gs-4060	472	20	the	the	DET
gs-4060	472	21	payload	payload	NOUN
gs-4060	472	22	(	(	PUNCT
gs-4060	472	23	the	the	DET
gs-4060	472	24	warhead	warhead	NOUN
gs-4060	472	25	,	,	PUNCT
gs-4060	472	26	often	often	ADV
gs-4060	472	27	a	a	DET
gs-4060	472	28	derivative	derivative	NOUN
gs-4060	472	29	of	of	ADP
gs-4060	472	30	a	a	DET
gs-4060	472	31	traditional	traditional	ADJ
gs-4060	472	32	chemotherapeutic	chemotherapeutic	NOUN
gs-4060	472	33	with	with	ADP
gs-4060	472	34	a	a	DET
gs-4060	472	35	mechanism	mechanism	NOUN
gs-4060	472	36	of	of	ADP
gs-4060	472	37	action	action	NOUN
gs-4060	472	38	such	such	ADJ
gs-4060	472	39	as	as	ADP
gs-4060	472	40	tubulin	tubulin	NOUN
gs-4060	472	41	inhibition	inhibition	NOUN
gs-4060	472	42	or	or	CCONJ
gs-4060	472	43	dna	dna	NOUN
gs-4060	472	44	damage	damage	NOUN
gs-4060	472	45	)	)	PUNCT
gs-4060	472	46	.	.	PUNCT
gs-4060	473	1	the	the	DET
gs-4060	473	2	clinical	clinical	ADJ
gs-4060	473	3	success	success	NOUN
gs-4060	473	4	of	of	ADP
gs-4060	473	5	adcs	adcs	ADV
gs-4060	473	6	like	like	ADP
gs-4060	473	7	trastuzumab	trastuzumab	NOUN
gs-4060	473	8	deruxtecan	deruxtecan	ADJ
gs-4060	473	9	,	,	PUNCT
gs-4060	473	10	particularly	particularly	ADV
gs-4060	473	11	in	in	ADP
gs-4060	473	12	cancers	cancer	NOUN
gs-4060	473	13	with	with	ADP
gs-4060	473	14	low	low	ADJ
gs-4060	473	15	-	-	PUNCT
gs-4060	473	16	level	level	NOUN
gs-4060	473	17	her2	her2	NOUN
gs-4060	473	18	expression	expression	NOUN
gs-4060	473	19	,	,	PUNCT
gs-4060	473	20	has	have	AUX
gs-4060	473	21	introduced	introduce	VERB
gs-4060	473	22	the	the	DET
gs-4060	473	23	concept	concept	NOUN
gs-4060	473	24	of	of	ADP
gs-4060	473	25	the	the	DET
gs-4060	473	26	"	"	PUNCT
gs-4060	473	27	her2	her2	NOUN
gs-4060	473	28	-	-	PUNCT
gs-4060	473	29	low	low	ADJ
gs-4060	473	30	"	"	PUNCT
gs-4060	473	31	breast	breast	NOUN
gs-4060	473	32	cancer	cancer	NOUN
gs-4060	473	33	subtype	subtype	NOUN
gs-4060	473	34	,	,	PUNCT
gs-4060	473	35	effectively	effectively	ADV
gs-4060	473	36	creating	create	VERB
gs-4060	473	37	a	a	DET
gs-4060	473	38	new	new	ADJ
gs-4060	473	39	biomarker	biomarker	NOUN
gs-4060	473	40	-	-	PUNCT
gs-4060	473	41	defined	define	VERB
gs-4060	473	42	population	population	NOUN
gs-4060	473	43	for	for	ADP
gs-4060	473	44	treatment	treatment	NOUN
gs-4060	473	45	.	.	PUNCT
gs-4060	474	1	this	this	DET
gs-4060	474	2	highlights	highlight	VERB
gs-4060	474	3	how	how	SCONJ
gs-4060	474	4	new	new	ADJ
gs-4060	474	5	drugs	drug	NOUN
gs-4060	474	6	can	can	AUX
gs-4060	474	7	redefine	redefine	VERB
gs-4060	474	8	disease	disease	NOUN
gs-4060	474	9	classification	classification	NOUN
gs-4060	474	10	.	.	PUNCT
gs-4060	475	1	a	a	DET
gs-4060	475	2	key	key	ADJ
gs-4060	475	3	toxicity	toxicity	NOUN
gs-4060	475	4	of	of	ADP
gs-4060	475	5	adcs	adcs	NOUN
gs-4060	475	6	is	be	AUX
gs-4060	475	7	off	off	ADP
gs-4060	475	8	-	-	PUNCT
gs-4060	475	9	target	target	NOUN
gs-4060	475	10	effects	effect	NOUN
gs-4060	475	11	,	,	PUNCT
gs-4060	475	12	which	which	PRON
gs-4060	475	13	can	can	AUX
gs-4060	475	14	occur	occur	VERB
gs-4060	475	15	if	if	SCONJ
gs-4060	475	16	the	the	DET
gs-4060	475	17	linker	linker	NOUN
gs-4060	475	18	is	be	AUX
gs-4060	475	19	unstable	unstable	ADJ
gs-4060	475	20	in	in	ADP
gs-4060	475	21	the	the	DET
gs-4060	475	22	plasma	plasma	NOUN
gs-4060	475	23	,	,	PUNCT
gs-4060	475	24	releasing	release	VERB
gs-4060	475	25	the	the	DET
gs-4060	475	26	payload	payload	NOUN
gs-4060	475	27	prematurely	prematurely	ADV
gs-4060	475	28	and	and	CCONJ
gs-4060	475	29	causing	cause	VERB
gs-4060	475	30	systemic	systemic	ADJ
gs-4060	475	31	toxicities	toxicity	NOUN
gs-4060	475	32	reminiscent	reminiscent	ADJ
gs-4060	475	33	of	of	ADP
gs-4060	475	34	traditional	traditional	ADJ
gs-4060	475	35	chemotherapy	chemotherapy	NOUN
gs-4060	475	36	,	,	PUNCT
gs-4060	475	37	such	such	ADJ
gs-4060	475	38	as	as	ADP
gs-4060	475	39	neutropenia	neutropenia	NOUN
gs-4060	475	40	or	or	CCONJ
gs-4060	475	41	thrombocytopenia	thrombocytopenia	PROPN
gs-4060	475	42	.	.	PUNCT
gs-4060	476	1	the	the	DET
gs-4060	476	2	pervasive	pervasive	ADJ
gs-4060	476	3	challenge	challenge	NOUN
gs-4060	476	4	of	of	ADP
gs-4060	476	5	resistance	resistance	NOUN
gs-4060	476	6	mechanisms	mechanism	VERB
gs-4060	476	7	the	the	DET
gs-4060	476	8	development	development	NOUN
gs-4060	476	9	of	of	ADP
gs-4060	476	10	resistance	resistance	NOUN
gs-4060	476	11	is	be	AUX
gs-4060	476	12	a	a	DET
gs-4060	476	13	near	near	ADJ
gs-4060	476	14	-	-	PUNCT
gs-4060	476	15	universal	universal	ADJ
gs-4060	476	16	phenomenon	phenomenon	NOUN
gs-4060	476	17	that	that	PRON
gs-4060	476	18	ultimately	ultimately	ADV
gs-4060	476	19	limits	limit	VERB
gs-4060	476	20	the	the	DET
gs-4060	476	21	benefit	benefit	NOUN
gs-4060	476	22	of	of	ADP
gs-4060	476	23	both	both	DET
gs-4060	476	24	targeted	targeted	ADJ
gs-4060	476	25	and	and	CCONJ
gs-4060	476	26	immunotherapeutic	immunotherapeutic	ADJ
gs-4060	476	27	agents	agent	NOUN
gs-4060	476	28	.	.	PUNCT
gs-4060	477	1	the	the	DET
gs-4060	477	2	mechanisms	mechanism	NOUN
gs-4060	477	3	of	of	ADP
gs-4060	477	4	resistance	resistance	NOUN
gs-4060	477	5	to	to	ADP
gs-4060	477	6	targeted	target	VERB
gs-4060	477	7	therapies	therapy	NOUN
gs-4060	477	8	are	be	AUX
gs-4060	477	9	multifaceted	multifaceted	ADJ
gs-4060	477	10	.	.	PUNCT
gs-4060	478	1	on	on	ADP
gs-4060	478	2	-	-	PUNCT
gs-4060	478	3	target	target	NOUN
gs-4060	478	4	resistance	resistance	NOUN
gs-4060	478	5	involves	involve	VERB
gs-4060	478	6	mutations	mutation	NOUN
gs-4060	478	7	in	in	ADP
gs-4060	478	8	the	the	DET
gs-4060	478	9	drug	drug	NOUN
gs-4060	478	10	’s	’s	PART
gs-4060	478	11	binding	bind	VERB
gs-4060	478	12	site	site	NOUN
gs-4060	478	13	that	that	PRON
gs-4060	478	14	reduce	reduce	VERB
gs-4060	478	15	drug	drug	NOUN
gs-4060	478	16	affinity	affinity	NOUN
gs-4060	478	17	,	,	PUNCT
gs-4060	478	18	as	as	SCONJ
gs-4060	478	19	seen	see	VERB
gs-4060	478	20	with	with	ADP
gs-4060	478	21	the	the	DET
gs-4060	478	22	aforementioned	aforementioned	ADJ
gs-4060	478	23	t790	t790	NUM
gs-4060	478	24	m	m	NOUN
gs-4060	478	25	and	and	CCONJ
gs-4060	478	26	c797s	c797s	ADJ
gs-4060	478	27	mutations	mutation	NOUN
gs-4060	478	28	in	in	ADP
gs-4060	478	29	egfr	egfr	NOUN
gs-4060	478	30	,	,	PUNCT
gs-4060	478	31	or	or	CCONJ
gs-4060	478	32	gatekeeper	gatekeeper	NOUN
gs-4060	478	33	mutations	mutation	NOUN
gs-4060	478	34	in	in	ADP
gs-4060	478	35	other	other	ADJ
gs-4060	478	36	kinases	kinase	NOUN
gs-4060	478	37	.	.	PUNCT
gs-4060	479	1	off	off	ADP
gs-4060	479	2	-	-	PUNCT
gs-4060	479	3	target	target	NOUN
gs-4060	479	4	resistance	resistance	NOUN
gs-4060	479	5	involves	involve	VERB
gs-4060	479	6	the	the	DET
gs-4060	479	7	activation	activation	NOUN
gs-4060	479	8	of	of	ADP
gs-4060	479	9	alternative	alternative	ADJ
gs-4060	479	10	signaling	signal	VERB
gs-4060	479	11	pathways	pathway	NOUN
gs-4060	479	12	that	that	PRON
gs-4060	479	13	bypass	bypass	VERB
gs-4060	479	14	the	the	DET
gs-4060	479	15	inhibited	inhibited	ADJ
gs-4060	479	16	target	target	NOUN
gs-4060	479	17	.	.	PUNCT
gs-4060	480	1	for	for	ADP
gs-4060	480	2	example	example	NOUN
gs-4060	480	3	,	,	PUNCT
gs-4060	480	4	met	meet	VERB
gs-4060	480	5	amplification	amplification	NOUN
gs-4060	480	6	can	can	AUX
gs-4060	480	7	drive	drive	VERB
gs-4060	480	8	resistance	resistance	NOUN
gs-4060	480	9	to	to	AUX
gs-4060	480	10	egfr	egfr	VERB
gs-4060	480	11	inhibitors	inhibitor	NOUN
gs-4060	480	12	by	by	ADP
gs-4060	480	13	reactivating	reactivate	VERB
gs-4060	480	14	the	the	DET
gs-4060	480	15	downstream	downstream	ADJ
gs-4060	480	16	pi3k	pi3k	PROPN
gs-4060	480	17	/	/	SYM
gs-4060	480	18	akt	akt	PROPN
gs-4060	480	19	pathway	pathway	NOUN
gs-4060	480	20	.	.	PUNCT
gs-4060	481	1	phenotypic	phenotypic	ADJ
gs-4060	481	2	transformation	transformation	NOUN
gs-4060	481	3	,	,	PUNCT
gs-4060	481	4	such	such	ADJ
gs-4060	481	5	as	as	ADP
gs-4060	481	6	the	the	DET
gs-4060	481	7	epithelial	epithelial	NOUN
gs-4060	481	8	-	-	PUNCT
gs-4060	481	9	to	to	ADP
gs-4060	481	10	-	-	PUNCT
gs-4060	481	11	mesenchymal	mesenchymal	NOUN
gs-4060	481	12	transition	transition	NOUN
gs-4060	481	13	,	,	PUNCT
gs-4060	481	14	can	can	AUX
gs-4060	481	15	also	also	ADV
gs-4060	481	16	confer	confer	VERB
gs-4060	481	17	a	a	DET
gs-4060	481	18	more	more	ADV
gs-4060	481	19	aggressive	aggressive	ADJ
gs-4060	481	20	,	,	PUNCT
gs-4060	481	21	drug	drug	NOUN
gs-4060	481	22	-	-	PUNCT
gs-4060	481	23	resistant	resistant	ADJ
gs-4060	481	24	state	state	NOUN
gs-4060	481	25	.	.	PUNCT
gs-4060	482	1	finally	finally	ADV
gs-4060	482	2	,	,	PUNCT
gs-4060	482	3	tumor	tumor	NOUN
gs-4060	482	4	heterogeneity	heterogeneity	NOUN
gs-4060	482	5	ensures	ensure	VERB
gs-4060	482	6	that	that	SCONJ
gs-4060	482	7	pre	pre	ADJ
gs-4060	482	8	-	-	ADJ
gs-4060	482	9	existing	exist	VERB
gs-4060	482	10	resistant	resistant	ADJ
gs-4060	482	11	clones	clone	NOUN
gs-4060	482	12	are	be	AUX
gs-4060	482	13	selected	select	VERB
gs-4060	482	14	for	for	ADP
gs-4060	482	15	under	under	ADP
gs-4060	482	16	the	the	DET
gs-4060	482	17	selective	selective	ADJ
gs-4060	482	18	pressure	pressure	NOUN
gs-4060	482	19	of	of	ADP
gs-4060	482	20	therapy	therapy	NOUN
gs-4060	482	21	.	.	PUNCT
gs-4060	483	1	resistance	resistance	NOUN
gs-4060	483	2	to	to	ADP
gs-4060	483	3	immunotherapy	immunotherapy	NOUN
gs-4060	483	4	is	be	AUX
gs-4060	483	5	equally	equally	ADV
gs-4060	483	6	complex	complex	ADJ
gs-4060	483	7	and	and	CCONJ
gs-4060	483	8	less	less	ADV
gs-4060	483	9	well	well	ADV
gs-4060	483	10	-	-	PUNCT
gs-4060	483	11	characterized	characterize	VERB
gs-4060	483	12	.	.	PUNCT
gs-4060	484	1	it	it	PRON
gs-4060	484	2	can	can	AUX
gs-4060	484	3	be	be	AUX
gs-4060	484	4	categorized	categorize	VERB
gs-4060	484	5	into	into	ADP
gs-4060	484	6	primary	primary	ADJ
gs-4060	484	7	resistance	resistance	NOUN
gs-4060	484	8	(	(	PUNCT
gs-4060	484	9	no	no	DET
gs-4060	484	10	initial	initial	ADJ
gs-4060	484	11	response	response	NOUN
gs-4060	484	12	)	)	PUNCT
gs-4060	484	13	and	and	CCONJ
gs-4060	484	14	acquired	acquire	VERB
gs-4060	484	15	resistance	resistance	NOUN
gs-4060	484	16	(	(	PUNCT
gs-4060	484	17	response	response	NOUN
gs-4060	484	18	followed	follow	VERB
gs-4060	484	19	by	by	ADP
gs-4060	484	20	progression	progression	NOUN
gs-4060	484	21	)	)	PUNCT
gs-4060	484	22	.	.	PUNCT
gs-4060	485	1	mechanisms	mechanism	NOUN
gs-4060	485	2	include	include	VERB
gs-4060	485	3	a	a	DET
gs-4060	485	4	lack	lack	NOUN
gs-4060	485	5	of	of	ADP
gs-4060	485	6	tumor	tumor	NOUN
gs-4060	485	7	immunogenicity	immunogenicity	NOUN
gs-4060	485	8	,	,	PUNCT
gs-4060	485	9	often	often	ADV
gs-4060	485	10	due	due	ADP
gs-4060	485	11	to	to	ADP
gs-4060	485	12	a	a	DET
gs-4060	485	13	low	low	ADJ
gs-4060	485	14	tumor	tumor	NOUN
gs-4060	485	15	mutational	mutational	ADJ
gs-4060	485	16	burden	burden	NOUN
gs-4060	485	17	or	or	CCONJ
gs-4060	485	18	defects	defect	NOUN
gs-4060	485	19	in	in	ADP
gs-4060	485	20	antigen	antigen	ADJ
gs-4060	485	21	presentation	presentation	NOUN
gs-4060	485	22	machinery	machinery	NOUN
gs-4060	485	23	.	.	PUNCT
gs-4060	486	1	the	the	DET
gs-4060	486	2	tumor	tumor	NOUN
gs-4060	486	3	microenvironment	microenvironment	NOUN
gs-4060	486	4	can	can	AUX
gs-4060	486	5	be	be	AUX
gs-4060	486	6	a	a	DET
gs-4060	486	7	physical	physical	ADJ
gs-4060	486	8	and	and	CCONJ
gs-4060	486	9	functional	functional	ADJ
gs-4060	486	10	barrier	barrier	NOUN
gs-4060	486	11	,	,	PUNCT
gs-4060	486	12	populated	populate	VERB
gs-4060	486	13	with	with	ADP
gs-4060	486	14	immunosuppressive	immunosuppressive	ADJ
gs-4060	486	15	cells	cell	NOUN
gs-4060	486	16	like	like	ADP
gs-4060	486	17	regulatory	regulatory	ADJ
gs-4060	486	18	tcells	tcell	NOUN
gs-4060	486	19	,	,	PUNCT
gs-4060	486	20	myeloid	myeloid	NOUN
gs-4060	486	21	-	-	PUNCT
gs-4060	486	22	derived	derive	VERB
gs-4060	486	23	suppressor	suppressor	NOUN
gs-4060	486	24	cells	cell	NOUN
gs-4060	486	25	,	,	PUNCT
gs-4060	486	26	and	and	CCONJ
gs-4060	486	27	m2	m2	PROPN
gs-4060	486	28	macrophages	macrophage	NOUN
gs-4060	486	29	,	,	PUNCT
gs-4060	486	30	and	and	CCONJ
gs-4060	486	31	characterized	characterize	VERB
gs-4060	486	32	by	by	ADP
gs-4060	486	33	the	the	DET
gs-4060	486	34	expression	expression	NOUN
gs-4060	486	35	of	of	ADP
gs-4060	486	36	other	other	ADJ
gs-4060	486	37	inhibitory	inhibitory	ADJ
gs-4060	486	38	immune	immune	ADJ
gs-4060	486	39	checkpoints	checkpoint	NOUN
gs-4060	486	40	beyond	beyond	ADP
gs-4060	486	41	pd-1	pd-1	NOUN
gs-4060	486	42	/	/	SYM
gs-4060	486	43	ctla-4	ctla-4	NOUN
gs-4060	486	44	.	.	PUNCT
gs-4060	487	1	t	t	NOUN
gs-4060	487	2	-	-	PUNCT
gs-4060	487	3	cell	cell	NOUN
gs-4060	487	4	exhaustion	exhaustion	NOUN
gs-4060	487	5	,	,	PUNCT
gs-4060	487	6	a	a	DET
gs-4060	487	7	state	state	NOUN
gs-4060	487	8	of	of	ADP
gs-4060	487	9	dysfunction	dysfunction	NOUN
gs-4060	487	10	characterized	characterize	VERB
gs-4060	487	11	by	by	ADP
gs-4060	487	12	progressive	progressive	ADJ
gs-4060	487	13	loss	loss	NOUN
gs-4060	487	14	of	of	ADP
gs-4060	487	15	effector	effector	NOUN
gs-4060	487	16	function	function	NOUN
gs-4060	487	17	and	and	CCONJ
gs-4060	487	18	sustained	sustain	VERB
gs-4060	487	19	expression	expression	NOUN
gs-4060	487	20	of	of	ADP
gs-4060	487	21	inhibitory	inhibitory	ADJ
gs-4060	487	22	receptors	receptor	NOUN
gs-4060	487	23	,	,	PUNCT
gs-4060	487	24	can	can	AUX
gs-4060	487	25	render	render	VERB
gs-4060	487	26	infiltrating	infiltrating	ADJ
gs-4060	487	27	t	t	PROPN
gs-4060	487	28	-	-	PUNCT
gs-4060	487	29	cells	cell	NOUN
gs-4060	487	30	incapable	incapable	ADJ
gs-4060	487	31	of	of	ADP
gs-4060	487	32	mounting	mount	VERB
gs-4060	487	33	an	an	DET
gs-4060	487	34	effective	effective	ADJ
gs-4060	487	35	attack	attack	NOUN
gs-4060	487	36	.	.	PUNCT
gs-4060	488	1	strategies	strategy	NOUN
gs-4060	488	2	to	to	PART
gs-4060	488	3	overcome	overcome	VERB
gs-4060	488	4	these	these	DET
gs-4060	488	5	barriers	barrier	NOUN
gs-4060	488	6	are	be	AUX
gs-4060	488	7	the	the	DET
gs-4060	488	8	focus	focus	NOUN
gs-4060	488	9	of	of	ADP
gs-4060	488	10	intense	intense	ADJ
gs-4060	488	11	research	research	NOUN
gs-4060	488	12	,	,	PUNCT
gs-4060	488	13	including	include	VERB
gs-4060	488	14	combinations	combination	NOUN
gs-4060	488	15	of	of	ADP
gs-4060	488	16	different	different	ADJ
gs-4060	488	17	immunotherapies	immunotherapy	NOUN
gs-4060	488	18	,	,	PUNCT
gs-4060	488	19	therapies	therapy	NOUN
gs-4060	488	20	to	to	PART
gs-4060	488	21	modulate	modulate	VERB
gs-4060	488	22	the	the	DET
gs-4060	488	23	tumor	tumor	NOUN
gs-4060	488	24	microenvironment	microenvironment	NOUN
gs-4060	488	25	,	,	PUNCT
gs-4060	488	26	and	and	CCONJ
gs-4060	488	27	engineered	engineer	VERB
gs-4060	488	28	cellular	cellular	ADJ
gs-4060	488	29	therapies	therapy	NOUN
gs-4060	488	30	designed	design	VERB
gs-4060	488	31	to	to	PART
gs-4060	488	32	resist	resist	VERB
gs-4060	488	33	exhaustion	exhaustion	NOUN
gs-4060	488	34	.	.	PUNCT
gs-4060	489	1	the	the	DET
gs-4060	489	2	art	art	NOUN
gs-4060	489	3	and	and	CCONJ
gs-4060	489	4	science	science	NOUN
gs-4060	489	5	of	of	ADP
gs-4060	489	6	combination	combination	NOUN
gs-4060	489	7	therapies	therapy	NOUN
gs-4060	489	8	given	give	VERB
gs-4060	489	9	the	the	DET
gs-4060	489	10	inevitability	inevitability	NOUN
gs-4060	489	11	of	of	ADP
gs-4060	489	12	resistance	resistance	NOUN
gs-4060	489	13	,	,	PUNCT
gs-4060	489	14	combination	combination	NOUN
gs-4060	489	15	therapies	therapy	NOUN
gs-4060	489	16	have	have	AUX
gs-4060	489	17	become	become	VERB
gs-4060	489	18	the	the	DET
gs-4060	489	19	cornerstone	cornerstone	NOUN
gs-4060	489	20	of	of	ADP
gs-4060	489	21	clinical	clinical	ADJ
gs-4060	489	22	development	development	NOUN
gs-4060	489	23	.	.	PUNCT
gs-4060	490	1	these	these	DET
gs-4060	490	2	strategies	strategy	NOUN
gs-4060	490	3	are	be	AUX
gs-4060	490	4	designed	design	VERB
gs-4060	490	5	to	to	PART
gs-4060	490	6	attack	attack	VERB
gs-4060	490	7	the	the	DET
gs-4060	490	8	cancer	cancer	NOUN
gs-4060	490	9	on	on	ADP
gs-4060	490	10	multiple	multiple	ADJ
gs-4060	490	11	fronts	front	NOUN
gs-4060	490	12	,	,	PUNCT
gs-4060	490	13	increasing	increase	VERB
gs-4060	490	14	the	the	DET
gs-4060	490	15	therapeutic	therapeutic	ADJ
gs-4060	490	16	index	index	NOUN
gs-4060	490	17	and	and	CCONJ
gs-4060	490	18	delaying	delay	VERB
gs-4060	490	19	or	or	CCONJ
gs-4060	490	20	preventing	prevent	VERB
gs-4060	490	21	resistance	resistance	NOUN
gs-4060	490	22	.	.	PUNCT
gs-4060	491	1	the	the	DET
gs-4060	491	2	rationale	rationale	NOUN
gs-4060	491	3	for	for	ADP
gs-4060	491	4	combinations	combination	NOUN
gs-4060	491	5	is	be	AUX
gs-4060	491	6	multi	multi	ADJ
gs-4060	491	7	-	-	ADJ
gs-4060	491	8	pronged	pronged	ADJ
gs-4060	491	9	.	.	PUNCT
gs-4060	492	1	targeted	target	VERB
gs-4060	492	2	therapy	therapy	NOUN
gs-4060	492	3	combinations	combination	NOUN
gs-4060	492	4	,	,	PUNCT
gs-4060	492	5	as	as	ADP
gs-4060	492	6	with	with	ADP
gs-4060	492	7	braf	braf	NOUN
gs-4060	492	8	and	and	CCONJ
gs-4060	492	9	mek	mek	NOUN
gs-4060	492	10	inhibition	inhibition	NOUN
gs-4060	492	11	,	,	PUNCT
gs-4060	492	12	aim	aim	VERB
gs-4060	492	13	to	to	PART
gs-4060	492	14	achieve	achieve	VERB
gs-4060	492	15	vertical	vertical	ADJ
gs-4060	492	16	pathway	pathway	NOUN
gs-4060	492	17	inhibition	inhibition	NOUN
gs-4060	492	18	to	to	PART
gs-4060	492	19	block	block	NOUN
gs-4060	492	20	feedback	feedback	NOUN
gs-4060	492	21	loops	loop	NOUN
gs-4060	492	22	and	and	CCONJ
gs-4060	492	23	escape	escape	VERB
gs-4060	492	24	routes	route	NOUN
gs-4060	492	25	.	.	PUNCT
gs-4060	493	1	another	another	DET
gs-4060	493	2	strategy	strategy	NOUN
gs-4060	493	3	is	be	AUX
gs-4060	493	4	horizontal	horizontal	ADJ
gs-4060	493	5	pathway	pathway	NOUN
gs-4060	493	6	combination	combination	NOUN
gs-4060	493	7	,	,	PUNCT
gs-4060	493	8	targeting	target	VERB
gs-4060	493	9	two	two	NUM
gs-4060	493	10	parallel	parallel	ADJ
gs-4060	493	11	oncogenic	oncogenic	ADJ
gs-4060	493	12	drivers	driver	NOUN
gs-4060	493	13	.	.	PUNCT
gs-4060	494	1	combining	combine	VERB
gs-4060	494	2	agents	agent	NOUN
gs-4060	494	3	that	that	PRON
gs-4060	494	4	target	target	VERB
gs-4060	494	5	different	different	ADJ
gs-4060	494	6	hallmarks	hallmark	NOUN
gs-4060	494	7	of	of	ADP
gs-4060	494	8	cancer	cancer	NOUN
gs-4060	494	9	,	,	PUNCT
gs-4060	494	10	such	such	ADJ
gs-4060	494	11	as	as	ADP
gs-4060	494	12	angiogenesis	angiogenesis	NOUN
gs-4060	494	13	and	and	CCONJ
gs-4060	494	14	cell	cell	NOUN
gs-4060	494	15	proliferation	proliferation	NOUN
gs-4060	494	16	,	,	PUNCT
gs-4060	494	17	is	be	AUX
gs-4060	494	18	also	also	ADV
gs-4060	494	19	a	a	DET
gs-4060	494	20	validated	validated	ADJ
gs-4060	494	21	georgian	georgian	NOUN
gs-4060	494	22	scientists/	scientists/	NUM
gs-4060	494	23	.	.	PUNCT
gs-4060	495	1	7	7	NUM
gs-4060	495	2	n	n	PRON
gs-4060	495	3	3	3	NUM
gs-4060	495	4	,	,	PUNCT
gs-4060	495	5	2025	2025	NUM
gs-4060	495	6	592	592	NUM
gs-4060	495	7	approach	approach	NOUN
gs-4060	495	8	,	,	PUNCT
gs-4060	495	9	exemplified	exemplify	VERB
gs-4060	495	10	by	by	ADP
gs-4060	495	11	the	the	DET
gs-4060	495	12	combination	combination	NOUN
gs-4060	495	13	of	of	ADP
gs-4060	495	14	an	an	DET
gs-4060	495	15	anti	anti	ADJ
gs-4060	495	16	-	-	ADJ
gs-4060	495	17	vegf	vegf	ADJ
gs-4060	495	18	antibody	antibody	NOUN
gs-4060	495	19	with	with	ADP
gs-4060	495	20	chemotherapy	chemotherapy	NOUN
gs-4060	495	21	in	in	ADP
gs-4060	495	22	many	many	ADJ
gs-4060	495	23	solid	solid	ADJ
gs-4060	495	24	tumors	tumor	NOUN
gs-4060	495	25	.	.	PUNCT
gs-4060	496	1	combining	combine	VERB
gs-4060	496	2	targeted	target	VERB
gs-4060	496	3	therapy	therapy	NOUN
gs-4060	496	4	with	with	ADP
gs-4060	496	5	immunotherapy	immunotherapy	NOUN
gs-4060	496	6	is	be	AUX
gs-4060	496	7	a	a	DET
gs-4060	496	8	particularly	particularly	ADV
gs-4060	496	9	enticing	enticing	ADJ
gs-4060	496	10	but	but	CCONJ
gs-4060	496	11	challenging	challenging	ADJ
gs-4060	496	12	strategy	strategy	NOUN
gs-4060	496	13	.	.	PUNCT
gs-4060	497	1	targeted	target	VERB
gs-4060	497	2	agents	agent	NOUN
gs-4060	497	3	can	can	AUX
gs-4060	497	4	potentially	potentially	ADV
gs-4060	497	5	enhance	enhance	VERB
gs-4060	497	6	the	the	DET
gs-4060	497	7	immunogenicity	immunogenicity	NOUN
gs-4060	497	8	of	of	ADP
gs-4060	497	9	the	the	DET
gs-4060	497	10	tumor	tumor	NOUN
gs-4060	497	11	by	by	ADP
gs-4060	497	12	inducing	induce	VERB
gs-4060	497	13	cell	cell	NOUN
gs-4060	497	14	death	death	NOUN
gs-4060	497	15	and	and	CCONJ
gs-4060	497	16	antigen	antigen	ADJ
gs-4060	497	17	release	release	NOUN
gs-4060	497	18	or	or	CCONJ
gs-4060	497	19	by	by	ADP
gs-4060	497	20	modulating	modulate	VERB
gs-4060	497	21	the	the	DET
gs-4060	497	22	immunosuppressive	immunosuppressive	ADJ
gs-4060	497	23	microenvironment	microenvironment	NOUN
gs-4060	497	24	.	.	PUNCT
gs-4060	498	1	for	for	ADP
gs-4060	498	2	instance	instance	NOUN
gs-4060	498	3	,	,	PUNCT
gs-4060	498	4	some	some	DET
gs-4060	498	5	braf	braf	NOUN
gs-4060	498	6	inhibitors	inhibitor	NOUN
gs-4060	498	7	have	have	AUX
gs-4060	498	8	been	be	AUX
gs-4060	498	9	shown	show	VERB
gs-4060	498	10	to	to	PART
gs-4060	498	11	increase	increase	VERB
gs-4060	498	12	t	t	NOUN
gs-4060	498	13	-	-	PUNCT
gs-4060	498	14	cell	cell	NOUN
gs-4060	498	15	infiltration	infiltration	NOUN
gs-4060	498	16	into	into	ADP
gs-4060	498	17	melanoma	melanoma	ADJ
gs-4060	498	18	tumors	tumor	NOUN
gs-4060	498	19	.	.	PUNCT
gs-4060	499	1	however	however	ADV
gs-4060	499	2	,	,	PUNCT
gs-4060	499	3	these	these	DET
gs-4060	499	4	combinations	combination	NOUN
gs-4060	499	5	can	can	AUX
gs-4060	499	6	also	also	ADV
gs-4060	499	7	be	be	AUX
gs-4060	499	8	limited	limit	VERB
gs-4060	499	9	by	by	ADP
gs-4060	499	10	overlapping	overlap	VERB
gs-4060	499	11	toxicities	toxicity	NOUN
gs-4060	499	12	,	,	PUNCT
gs-4060	499	13	and	and	CCONJ
gs-4060	499	14	the	the	DET
gs-4060	499	15	optimal	optimal	ADJ
gs-4060	499	16	sequencing	sequencing	NOUN
gs-4060	499	17	of	of	ADP
gs-4060	499	18	these	these	DET
gs-4060	499	19	modalities	modality	NOUN
gs-4060	499	20	remains	remain	VERB
gs-4060	499	21	an	an	DET
gs-4060	499	22	open	open	ADJ
gs-4060	499	23	question	question	NOUN
gs-4060	499	24	for	for	ADP
gs-4060	499	25	ongoing	ongoing	ADJ
gs-4060	499	26	clinical	clinical	ADJ
gs-4060	499	27	trials	trial	NOUN
gs-4060	499	28	.	.	PUNCT
gs-4060	500	1	immunotherapy	immunotherapy	NOUN
gs-4060	500	2	combinations	combination	NOUN
gs-4060	500	3	,	,	PUNCT
gs-4060	500	4	most	most	ADV
gs-4060	500	5	notably	notably	ADV
gs-4060	500	6	the	the	DET
gs-4060	500	7	pairing	pairing	NOUN
gs-4060	500	8	of	of	ADP
gs-4060	500	9	anti	anti	ADJ
gs-4060	500	10	-	-	ADJ
gs-4060	500	11	ctla-4	ctla-4	NOUN
gs-4060	500	12	and	and	CCONJ
gs-4060	500	13	anti	anti	ADJ
gs-4060	500	14	-	-	ADJ
gs-4060	500	15	pd-1	pd-1	ADJ
gs-4060	500	16	antibodies	antibody	NOUN
gs-4060	500	17	,	,	PUNCT
gs-4060	500	18	leverage	leverage	NOUN
gs-4060	500	19	non	non	ADJ
gs-4060	500	20	-	-	ADJ
gs-4060	500	21	redundant	redundant	ADJ
gs-4060	500	22	mechanisms	mechanism	NOUN
gs-4060	500	23	of	of	ADP
gs-4060	500	24	action	action	NOUN
gs-4060	500	25	.	.	PUNCT
gs-4060	501	1	ctla-4	ctla-4	NOUN
gs-4060	501	2	inhibition	inhibition	NOUN
gs-4060	501	3	is	be	AUX
gs-4060	501	4	thought	think	VERB
gs-4060	501	5	to	to	PART
gs-4060	501	6	act	act	VERB
gs-4060	501	7	primarily	primarily	ADV
gs-4060	501	8	in	in	ADP
gs-4060	501	9	the	the	DET
gs-4060	501	10	lymphoid	lymphoid	ADJ
gs-4060	501	11	organs	organ	NOUN
gs-4060	501	12	,	,	PUNCT
gs-4060	501	13	boosting	boost	VERB
gs-4060	501	14	the	the	DET
gs-4060	501	15	priming	priming	NOUN
gs-4060	501	16	and	and	CCONJ
gs-4060	501	17	activation	activation	NOUN
gs-4060	501	18	of	of	ADP
gs-4060	501	19	t	t	NOUN
gs-4060	501	20	-	-	PUNCT
gs-4060	501	21	cells	cell	NOUN
gs-4060	501	22	,	,	PUNCT
gs-4060	501	23	while	while	SCONJ
gs-4060	501	24	pd-1	pd-1	ADP
gs-4060	501	25	inhibition	inhibition	NOUN
gs-4060	501	26	acts	act	NOUN
gs-4060	501	27	predominantly	predominantly	ADV
gs-4060	501	28	at	at	ADP
gs-4060	501	29	the	the	DET
gs-4060	501	30	tumor	tumor	NOUN
gs-4060	501	31	bed	bed	NOUN
gs-4060	501	32	,	,	PUNCT
gs-4060	501	33	reversing	reverse	VERB
gs-4060	501	34	t	t	NOUN
gs-4060	501	35	-	-	PUNCT
gs-4060	501	36	cell	cell	NOUN
gs-4060	501	37	exhaustion	exhaustion	NOUN
gs-4060	501	38	.	.	PUNCT
gs-4060	502	1	this	this	DET
gs-4060	502	2	combination	combination	NOUN
gs-4060	502	3	has	have	AUX
gs-4060	502	4	proven	prove	VERB
gs-4060	502	5	highly	highly	ADV
gs-4060	502	6	effective	effective	ADJ
gs-4060	502	7	in	in	ADP
gs-4060	502	8	cancers	cancer	NOUN
gs-4060	502	9	like	like	ADP
gs-4060	502	10	melanoma	melanoma	NOUN
gs-4060	502	11	and	and	CCONJ
gs-4060	502	12	renal	renal	ADJ
gs-4060	502	13	cell	cell	NOUN
gs-4060	502	14	carcinoma	carcinoma	NOUN
gs-4060	502	15	but	but	CCONJ
gs-4060	502	16	at	at	ADP
gs-4060	502	17	the	the	DET
gs-4060	502	18	cost	cost	NOUN
gs-4060	502	19	of	of	ADP
gs-4060	502	20	significantly	significantly	ADV
gs-4060	502	21	increased	increase	VERB
gs-4060	502	22	immune	immune	NOUN
gs-4060	502	23	-	-	PUNCT
gs-4060	502	24	related	relate	VERB
gs-4060	502	25	adverse	adverse	ADJ
gs-4060	502	26	events	event	NOUN
gs-4060	502	27	,	,	PUNCT
gs-4060	502	28	necessitating	necessitate	VERB
gs-4060	502	29	careful	careful	ADJ
gs-4060	502	30	patient	patient	ADJ
gs-4060	502	31	selection	selection	NOUN
gs-4060	502	32	and	and	CCONJ
gs-4060	502	33	expert	expert	NOUN
gs-4060	502	34	toxicity	toxicity	NOUN
gs-4060	502	35	management	management	NOUN
gs-4060	502	36	.	.	PUNCT
gs-4060	503	1	impact	impact	NOUN
gs-4060	503	2	on	on	ADP
gs-4060	503	3	special	special	ADJ
gs-4060	503	4	populations	population	NOUN
gs-4060	503	5	and	and	CCONJ
gs-4060	503	6	personalized	personalize	VERB
gs-4060	503	7	dosing	dose	VERB
gs-4060	503	8	the	the	DET
gs-4060	503	9	advent	advent	NOUN
gs-4060	503	10	of	of	ADP
gs-4060	503	11	these	these	DET
gs-4060	503	12	new	new	ADJ
gs-4060	503	13	agents	agent	NOUN
gs-4060	503	14	has	have	AUX
gs-4060	503	15	necessitated	necessitate	VERB
gs-4060	503	16	a	a	DET
gs-4060	503	17	re	re	NOUN
gs-4060	503	18	-	-	NOUN
gs-4060	503	19	evaluation	evaluation	NOUN
gs-4060	503	20	of	of	ADP
gs-4060	503	21	treatment	treatment	NOUN
gs-4060	503	22	approaches	approach	NOUN
gs-4060	503	23	in	in	ADP
gs-4060	503	24	special	special	ADJ
gs-4060	503	25	populations	population	NOUN
gs-4060	503	26	,	,	PUNCT
gs-4060	503	27	such	such	ADJ
gs-4060	503	28	as	as	ADP
gs-4060	503	29	patients	patient	NOUN
gs-4060	503	30	with	with	ADP
gs-4060	503	31	organ	organ	NOUN
gs-4060	503	32	dysfunction	dysfunction	NOUN
gs-4060	503	33	,	,	PUNCT
gs-4060	503	34	the	the	DET
gs-4060	503	35	elderly	elderly	ADJ
gs-4060	503	36	,	,	PUNCT
gs-4060	503	37	and	and	CCONJ
gs-4060	503	38	those	those	PRON
gs-4060	503	39	with	with	ADP
gs-4060	503	40	brain	brain	NOUN
gs-4060	503	41	metastases	metastasis	NOUN
gs-4060	503	42	.	.	PUNCT
gs-4060	504	1	the	the	DET
gs-4060	504	2	pharmacokinetics	pharmacokinetic	NOUN
gs-4060	504	3	of	of	ADP
gs-4060	504	4	small	small	ADJ
gs-4060	504	5	molecule	molecule	NOUN
gs-4060	504	6	inhibitors	inhibitor	NOUN
gs-4060	504	7	,	,	PUNCT
gs-4060	504	8	heavily	heavily	ADV
gs-4060	504	9	reliant	reliant	ADJ
gs-4060	504	10	on	on	ADP
gs-4060	504	11	hepatic	hepatic	ADJ
gs-4060	504	12	metabolism	metabolism	NOUN
gs-4060	504	13	and	and	CCONJ
gs-4060	504	14	biliary	biliary	NOUN
gs-4060	504	15	excretion	excretion	NOUN
gs-4060	504	16	,	,	PUNCT
gs-4060	504	17	can	can	AUX
gs-4060	504	18	be	be	AUX
gs-4060	504	19	significantly	significantly	ADV
gs-4060	504	20	altered	alter	VERB
gs-4060	504	21	in	in	ADP
gs-4060	504	22	patients	patient	NOUN
gs-4060	504	23	with	with	ADP
gs-4060	504	24	liver	liver	NOUN
gs-4060	504	25	impairment	impairment	NOUN
gs-4060	504	26	,	,	PUNCT
gs-4060	504	27	often	often	ADV
gs-4060	504	28	requiring	require	VERB
gs-4060	504	29	dose	dose	NOUN
gs-4060	504	30	modifications	modification	NOUN
gs-4060	504	31	as	as	SCONJ
gs-4060	504	32	detailed	detail	VERB
gs-4060	504	33	in	in	ADP
gs-4060	504	34	prescribing	prescribe	VERB
gs-4060	504	35	information	information	NOUN
gs-4060	504	36	.	.	PUNCT
gs-4060	505	1	similarly	similarly	ADV
gs-4060	505	2	,	,	PUNCT
gs-4060	505	3	renal	renal	ADJ
gs-4060	505	4	dysfunction	dysfunction	NOUN
gs-4060	505	5	can	can	AUX
gs-4060	505	6	affect	affect	VERB
gs-4060	505	7	the	the	DET
gs-4060	505	8	clearance	clearance	NOUN
gs-4060	505	9	of	of	ADP
gs-4060	505	10	agents	agent	NOUN
gs-4060	505	11	or	or	CCONJ
gs-4060	505	12	their	their	PRON
gs-4060	505	13	metabolites	metabolite	NOUN
gs-4060	505	14	,	,	PUNCT
gs-4060	505	15	though	though	SCONJ
gs-4060	505	16	this	this	PRON
gs-4060	505	17	is	be	AUX
gs-4060	505	18	a	a	DET
gs-4060	505	19	greater	great	ADJ
gs-4060	505	20	concern	concern	NOUN
gs-4060	505	21	for	for	ADP
gs-4060	505	22	cytotoxic	cytotoxic	ADJ
gs-4060	505	23	chemotherapies	chemotherapy	NOUN
gs-4060	505	24	than	than	ADP
gs-4060	505	25	for	for	ADP
gs-4060	505	26	most	most	ADJ
gs-4060	505	27	targeted	target	VERB
gs-4060	505	28	agents	agent	NOUN
gs-4060	505	29	.	.	PUNCT
gs-4060	506	1	the	the	DET
gs-4060	506	2	management	management	NOUN
gs-4060	506	3	of	of	ADP
gs-4060	506	4	immunotherapy	immunotherapy	NOUN
gs-4060	506	5	in	in	ADP
gs-4060	506	6	patients	patient	NOUN
gs-4060	506	7	with	with	ADP
gs-4060	506	8	underlying	underlying	ADJ
gs-4060	506	9	autoimmune	autoimmune	ADJ
gs-4060	506	10	diseases	disease	NOUN
gs-4060	506	11	was	be	AUX
gs-4060	506	12	initially	initially	ADV
gs-4060	506	13	a	a	DET
gs-4060	506	14	contraindication	contraindication	NOUN
gs-4060	506	15	due	due	ADP
gs-4060	506	16	to	to	ADP
gs-4060	506	17	fears	fear	NOUN
gs-4060	506	18	of	of	ADP
gs-4060	506	19	flare	flare	NOUN
gs-4060	506	20	,	,	PUNCT
gs-4060	506	21	but	but	CCONJ
gs-4060	506	22	growing	grow	VERB
gs-4060	506	23	clinical	clinical	ADJ
gs-4060	506	24	experience	experience	NOUN
gs-4060	506	25	suggests	suggest	VERB
gs-4060	506	26	that	that	SCONJ
gs-4060	506	27	with	with	ADP
gs-4060	506	28	close	close	ADJ
gs-4060	506	29	monitoring	monitoring	NOUN
gs-4060	506	30	and	and	CCONJ
gs-4060	506	31	collaboration	collaboration	NOUN
gs-4060	506	32	with	with	ADP
gs-4060	506	33	specialists	specialist	NOUN
gs-4060	506	34	,	,	PUNCT
gs-4060	506	35	many	many	ADJ
gs-4060	506	36	of	of	ADP
gs-4060	506	37	these	these	DET
gs-4060	506	38	patients	patient	NOUN
gs-4060	506	39	can	can	AUX
gs-4060	506	40	still	still	ADV
gs-4060	506	41	safely	safely	ADV
gs-4060	506	42	receive	receive	VERB
gs-4060	506	43	and	and	CCONJ
gs-4060	506	44	benefit	benefit	VERB
gs-4060	506	45	from	from	ADP
gs-4060	506	46	treatment	treatment	NOUN
gs-4060	506	47	.	.	PUNCT
gs-4060	507	1	the	the	DET
gs-4060	507	2	treatment	treatment	NOUN
gs-4060	507	3	of	of	ADP
gs-4060	507	4	central	central	ADJ
gs-4060	507	5	nervous	nervous	ADJ
gs-4060	507	6	system	system	NOUN
gs-4060	507	7	metastases	metastasis	NOUN
gs-4060	507	8	has	have	AUX
gs-4060	507	9	been	be	AUX
gs-4060	507	10	revolutionized	revolutionize	VERB
gs-4060	507	11	by	by	ADP
gs-4060	507	12	targeted	target	VERB
gs-4060	507	13	agents	agent	NOUN
gs-4060	507	14	with	with	ADP
gs-4060	507	15	high	high	ADJ
gs-4060	507	16	cns	cns	NOUN
gs-4060	507	17	penetration	penetration	NOUN
gs-4060	507	18	.	.	PUNCT
gs-4060	508	1	egfr	egfr	NOUN
gs-4060	508	2	and	and	CCONJ
gs-4060	508	3	alk	alk	VERB
gs-4060	508	4	inhibitors	inhibitor	NOUN
gs-4060	508	5	with	with	ADP
gs-4060	508	6	improved	improved	ADJ
gs-4060	508	7	brain	brain	NOUN
gs-4060	508	8	bioavailability	bioavailability	NOUN
gs-4060	508	9	,	,	PUNCT
gs-4060	508	10	such	such	ADJ
gs-4060	508	11	as	as	ADP
gs-4060	508	12	osimertinib	osimertinib	NOUN
gs-4060	508	13	and	and	CCONJ
gs-4060	508	14	lorlatinib	lorlatinib	NOUN
gs-4060	508	15	,	,	PUNCT
gs-4060	508	16	have	have	AUX
gs-4060	508	17	demonstrated	demonstrate	VERB
gs-4060	508	18	significant	significant	ADJ
gs-4060	508	19	intracranial	intracranial	ADJ
gs-4060	508	20	activity	activity	NOUN
gs-4060	508	21	,	,	PUNCT
gs-4060	508	22	often	often	ADV
gs-4060	508	23	obviating	obviate	VERB
gs-4060	508	24	or	or	CCONJ
gs-4060	508	25	delaying	delay	VERB
gs-4060	508	26	the	the	DET
gs-4060	508	27	need	need	NOUN
gs-4060	508	28	for	for	ADP
gs-4060	508	29	whole	whole	ADJ
gs-4060	508	30	-	-	PUNCT
gs-4060	508	31	brain	brain	NOUN
gs-4060	508	32	radiation	radiation	NOUN
gs-4060	508	33	and	and	CCONJ
gs-4060	508	34	its	its	PRON
gs-4060	508	35	associated	associated	ADJ
gs-4060	508	36	neurocognitive	neurocognitive	ADJ
gs-4060	508	37	sequelae	sequelae	NOUN
gs-4060	508	38	.	.	PUNCT
gs-4060	509	1	similarly	similarly	ADV
gs-4060	509	2	,	,	PUNCT
gs-4060	509	3	immunotherapy	immunotherapy	NOUN
gs-4060	509	4	has	have	AUX
gs-4060	509	5	shown	show	VERB
gs-4060	509	6	activity	activity	NOUN
gs-4060	509	7	in	in	ADP
gs-4060	509	8	brain	brain	NOUN
gs-4060	509	9	metastases	metastasis	NOUN
gs-4060	509	10	,	,	PUNCT
gs-4060	509	11	particularly	particularly	ADV
gs-4060	509	12	in	in	ADP
gs-4060	509	13	melanoma	melanoma	NOUN
gs-4060	509	14	and	and	CCONJ
gs-4060	509	15	lung	lung	NOUN
gs-4060	509	16	cancer	cancer	NOUN
gs-4060	509	17	,	,	PUNCT
gs-4060	509	18	challenging	challenge	VERB
gs-4060	509	19	the	the	DET
gs-4060	509	20	long	long	ADV
gs-4060	509	21	-	-	PUNCT
gs-4060	509	22	held	hold	VERB
gs-4060	509	23	notion	notion	NOUN
gs-4060	509	24	of	of	ADP
gs-4060	509	25	the	the	DET
gs-4060	509	26	brain	brain	NOUN
gs-4060	509	27	as	as	ADP
gs-4060	509	28	an	an	DET
gs-4060	509	29	immune	immune	NOUN
gs-4060	509	30	-	-	PUNCT
gs-4060	509	31	privileged	privileged	ADJ
gs-4060	509	32	sanctuary	sanctuary	ADJ
gs-4060	509	33	site	site	NOUN
gs-4060	509	34	.	.	PUNCT
gs-4060	510	1	the	the	DET
gs-4060	510	2	field	field	NOUN
gs-4060	510	3	is	be	AUX
gs-4060	510	4	moving	move	VERB
gs-4060	510	5	towards	towards	ADP
gs-4060	510	6	more	more	ADJ
gs-4060	510	7	refined	refined	ADJ
gs-4060	510	8	dosing	dose	VERB
gs-4060	510	9	strategies	strategy	NOUN
gs-4060	510	10	.	.	PUNCT
gs-4060	511	1	the	the	DET
gs-4060	511	2	traditional	traditional	ADJ
gs-4060	511	3	paradigm	paradigm	NOUN
gs-4060	511	4	of	of	ADP
gs-4060	511	5	using	use	VERB
gs-4060	511	6	the	the	DET
gs-4060	511	7	maximum	maximum	ADJ
gs-4060	511	8	tolerated	tolerate	VERB
gs-4060	511	9	dose	dose	NOUN
gs-4060	511	10	for	for	ADP
gs-4060	511	11	all	all	DET
gs-4060	511	12	patients	patient	NOUN
gs-4060	511	13	is	be	AUX
gs-4060	511	14	being	be	AUX
gs-4060	511	15	questioned	question	VERB
gs-4060	511	16	for	for	ADP
gs-4060	511	17	targeted	targeted	ADJ
gs-4060	511	18	and	and	CCONJ
gs-4060	511	19	immunotherapeutic	immunotherapeutic	ADJ
gs-4060	511	20	agents	agent	NOUN
gs-4060	511	21	,	,	PUNCT
gs-4060	511	22	where	where	SCONJ
gs-4060	511	23	the	the	DET
gs-4060	511	24	maximum	maximum	ADJ
gs-4060	511	25	efficacious	efficacious	ADJ
gs-4060	511	26	dose	dose	NOUN
gs-4060	511	27	may	may	AUX
gs-4060	511	28	be	be	AUX
gs-4060	511	29	lower	low	ADJ
gs-4060	511	30	and	and	CCONJ
gs-4060	511	31	where	where	SCONJ
gs-4060	511	32	longterm	longterm	ADJ
gs-4060	511	33	management	management	NOUN
gs-4060	511	34	of	of	ADP
gs-4060	511	35	chronic	chronic	ADJ
gs-4060	511	36	toxicities	toxicity	NOUN
gs-4060	511	37	is	be	AUX
gs-4060	511	38	paramount	paramount	ADJ
gs-4060	511	39	.	.	PUNCT
gs-4060	512	1	strategies	strategy	NOUN
gs-4060	512	2	such	such	ADJ
gs-4060	512	3	as	as	ADP
gs-4060	512	4	therapeutic	therapeutic	ADJ
gs-4060	512	5	drug	drug	NOUN
gs-4060	512	6	monitoring	monitoring	NOUN
gs-4060	512	7	,	,	PUNCT
gs-4060	512	8	pharmacogenomics	pharmacogenomic	NOUN
gs-4060	512	9	to	to	PART
gs-4060	512	10	predict	predict	VERB
gs-4060	512	11	metabolism	metabolism	NOUN
gs-4060	512	12	and	and	CCONJ
gs-4060	512	13	toxicity	toxicity	NOUN
gs-4060	512	14	risk	risk	NOUN
gs-4060	512	15	,	,	PUNCT
gs-4060	512	16	and	and	CCONJ
gs-4060	512	17	adaptive	adaptive	ADJ
gs-4060	512	18	dosing	dosing	NOUN
gs-4060	512	19	based	base	VERB
gs-4060	512	20	on	on	ADP
gs-4060	512	21	toxicity	toxicity	NOUN
gs-4060	512	22	are	be	AUX
gs-4060	512	23	areas	area	NOUN
gs-4060	512	24	of	of	ADP
gs-4060	512	25	active	active	ADJ
gs-4060	512	26	investigation	investigation	NOUN
gs-4060	512	27	to	to	PART
gs-4060	512	28	further	far	ADV
gs-4060	512	29	personalize	personalize	VERB
gs-4060	512	30	treatment	treatment	NOUN
gs-4060	512	31	and	and	CCONJ
gs-4060	512	32	optimize	optimize	VERB
gs-4060	512	33	the	the	DET
gs-4060	512	34	patient	patient	NOUN
gs-4060	512	35	's	's	PART
gs-4060	512	36	quality	quality	NOUN
gs-4060	512	37	of	of	ADP
gs-4060	512	38	life	life	NOUN
gs-4060	512	39	.	.	PUNCT
gs-4060	513	1	this	this	DET
gs-4060	513	2	continued	continue	VERB
gs-4060	513	3	exploration	exploration	NOUN
gs-4060	513	4	into	into	ADP
gs-4060	513	5	the	the	DET
gs-4060	513	6	nuances	nuance	NOUN
gs-4060	513	7	of	of	ADP
gs-4060	513	8	drug	drug	NOUN
gs-4060	513	9	classes	class	NOUN
gs-4060	513	10	,	,	PUNCT
gs-4060	513	11	resistance	resistance	NOUN
gs-4060	513	12	,	,	PUNCT
gs-4060	513	13	combinations	combination	NOUN
gs-4060	513	14	,	,	PUNCT
gs-4060	513	15	and	and	CCONJ
gs-4060	513	16	special	special	ADJ
gs-4060	513	17	patient	patient	NOUN
gs-4060	513	18	care	care	NOUN
gs-4060	513	19	underscores	underscore	VERB
gs-4060	513	20	the	the	DET
gs-4060	513	21	immense	immense	ADJ
gs-4060	513	22	complexity	complexity	NOUN
gs-4060	513	23	and	and	CCONJ
gs-4060	513	24	exciting	exciting	ADJ
gs-4060	513	25	progress	progress	NOUN
gs-4060	513	26	within	within	ADP
gs-4060	513	27	modern	modern	ADJ
gs-4060	513	28	georgian	georgian	NOUN
gs-4060	513	29	scientists/	scientists/	NUM
gs-4060	513	30	.	.	PUNCT
gs-4060	514	1	7	7	NUM
gs-4060	514	2	n	n	PRON
gs-4060	514	3	3	3	NUM
gs-4060	514	4	,	,	PUNCT
gs-4060	514	5	2025	2025	NUM
gs-4060	514	6	593	593	NUM
gs-4060	514	7	oncology	oncology	NOUN
gs-4060	514	8	.	.	PUNCT
gs-4060	515	1	the	the	DET
gs-4060	515	2	journey	journey	NOUN
gs-4060	515	3	from	from	ADP
gs-4060	515	4	a	a	DET
gs-4060	515	5	one	one	NUM
gs-4060	515	6	-	-	PUNCT
gs-4060	515	7	size	size	NOUN
gs-4060	515	8	-	-	PUNCT
gs-4060	515	9	fits	fit	VERB
gs-4060	515	10	-	-	PUNCT
gs-4060	515	11	all	all	PRON
gs-4060	515	12	approach	approach	NOUN
gs-4060	515	13	to	to	ADP
gs-4060	515	14	a	a	DET
gs-4060	515	15	nuanced	nuanced	ADJ
gs-4060	515	16	,	,	PUNCT
gs-4060	515	17	biomarker	biomarker	NOUN
gs-4060	515	18	-	-	PUNCT
gs-4060	515	19	driven	drive	VERB
gs-4060	515	20	,	,	PUNCT
gs-4060	515	21	and	and	CCONJ
gs-4060	515	22	increasingly	increasingly	ADV
gs-4060	515	23	personalized	personalize	VERB
gs-4060	515	24	discipline	discipline	NOUN
gs-4060	515	25	represents	represent	VERB
gs-4060	515	26	one	one	NUM
gs-4060	515	27	of	of	ADP
gs-4060	515	28	the	the	DET
gs-4060	515	29	most	most	ADV
gs-4060	515	30	significant	significant	ADJ
gs-4060	515	31	achievements	achievement	NOUN
gs-4060	515	32	in	in	ADP
gs-4060	515	33	contemporary	contemporary	ADJ
gs-4060	515	34	medicine	medicine	NOUN
gs-4060	515	35	.	.	PUNCT
gs-4060	516	1	the	the	DET
gs-4060	516	2	ongoing	ongoing	ADJ
gs-4060	516	3	dialogue	dialogue	NOUN
gs-4060	516	4	between	between	ADP
gs-4060	516	5	basic	basic	ADJ
gs-4060	516	6	science	science	NOUN
gs-4060	516	7	discovery	discovery	NOUN
gs-4060	516	8	,	,	PUNCT
gs-4060	516	9	translational	translational	ADJ
gs-4060	516	10	research	research	NOUN
gs-4060	516	11	,	,	PUNCT
gs-4060	516	12	and	and	CCONJ
gs-4060	516	13	clinical	clinical	ADJ
gs-4060	516	14	application	application	NOUN
gs-4060	516	15	ensures	ensure	VERB
gs-4060	516	16	that	that	SCONJ
gs-4060	516	17	this	this	DET
gs-4060	516	18	evolution	evolution	NOUN
gs-4060	516	19	will	will	AUX
gs-4060	516	20	continue	continue	VERB
gs-4060	516	21	,	,	PUNCT
gs-4060	516	22	offering	offer	VERB
gs-4060	516	23	ever	ever	ADV
gs-4060	516	24	-	-	PUNCT
gs-4060	516	25	greater	great	ADJ
gs-4060	516	26	hope	hope	NOUN
gs-4060	516	27	to	to	ADP
gs-4060	516	28	patients	patient	NOUN
gs-4060	516	29	.	.	PUNCT
gs-4060	517	1	emerging	emerge	VERB
gs-4060	517	2	frontiers	frontier	NOUN
gs-4060	517	3	:	:	PUNCT
gs-4060	517	4	novel	novel	ADJ
gs-4060	517	5	modalities	modality	NOUN
gs-4060	517	6	and	and	CCONJ
gs-4060	517	7	platforms	platform	NOUN
gs-4060	517	8	beyond	beyond	ADP
gs-4060	517	9	the	the	DET
gs-4060	517	10	established	establish	VERB
gs-4060	517	11	classes	class	NOUN
gs-4060	517	12	of	of	ADP
gs-4060	517	13	targeted	target	VERB
gs-4060	517	14	therapies	therapy	NOUN
gs-4060	517	15	and	and	CCONJ
gs-4060	517	16	immunotherapies	immunotherapy	NOUN
gs-4060	517	17	,	,	PUNCT
gs-4060	517	18	the	the	DET
gs-4060	517	19	oncological	oncological	ADJ
gs-4060	517	20	therapeutic	therapeutic	ADJ
gs-4060	517	21	arsenal	arsenal	NOUN
gs-4060	517	22	is	be	AUX
gs-4060	517	23	expanding	expand	VERB
gs-4060	517	24	to	to	PART
gs-4060	517	25	include	include	VERB
gs-4060	517	26	entirely	entirely	ADV
gs-4060	517	27	new	new	ADJ
gs-4060	517	28	platforms	platform	NOUN
gs-4060	517	29	that	that	PRON
gs-4060	517	30	operate	operate	VERB
gs-4060	517	31	on	on	ADP
gs-4060	517	32	distinct	distinct	ADJ
gs-4060	517	33	principles	principle	NOUN
gs-4060	517	34	.	.	PUNCT
gs-4060	518	1	among	among	ADP
gs-4060	518	2	the	the	DET
gs-4060	518	3	most	most	ADV
gs-4060	518	4	promising	promising	ADJ
gs-4060	518	5	are	be	AUX
gs-4060	518	6	proteolysis	proteolysis	NOUN
gs-4060	518	7	-	-	PUNCT
gs-4060	518	8	targeting	target	VERB
gs-4060	518	9	chimeras	chimera	NOUN
gs-4060	518	10	(	(	PUNCT
gs-4060	518	11	protacs	protacs	PROPN
gs-4060	518	12	)	)	PUNCT
gs-4060	518	13	,	,	PUNCT
gs-4060	518	14	a	a	DET
gs-4060	518	15	novel	novel	ADJ
gs-4060	518	16	technology	technology	NOUN
gs-4060	518	17	that	that	PRON
gs-4060	518	18	represents	represent	VERB
gs-4060	518	19	a	a	DET
gs-4060	518	20	paradigm	paradigm	NOUN
gs-4060	518	21	shift	shift	NOUN
gs-4060	518	22	from	from	ADP
gs-4060	518	23	inhibiting	inhibit	VERB
gs-4060	518	24	protein	protein	NOUN
gs-4060	518	25	function	function	NOUN
gs-4060	518	26	to	to	ADP
gs-4060	518	27	catalyzing	catalyze	VERB
gs-4060	518	28	its	its	PRON
gs-4060	518	29	complete	complete	ADJ
gs-4060	518	30	destruction	destruction	NOUN
gs-4060	518	31	.	.	PUNCT
gs-4060	519	1	unlike	unlike	ADP
gs-4060	519	2	traditional	traditional	ADJ
gs-4060	519	3	small	small	ADJ
gs-4060	519	4	molecule	molecule	NOUN
gs-4060	519	5	inhibitors	inhibitor	NOUN
gs-4060	519	6	that	that	PRON
gs-4060	519	7	occupy	occupy	VERB
gs-4060	519	8	an	an	DET
gs-4060	519	9	active	active	ADJ
gs-4060	519	10	site	site	NOUN
gs-4060	519	11	and	and	CCONJ
gs-4060	519	12	require	require	VERB
gs-4060	519	13	sustained	sustained	ADJ
gs-4060	519	14	binding	bind	VERB
gs-4060	519	15	to	to	AUX
gs-4060	519	16	block	block	NOUN
gs-4060	519	17	function	function	NOUN
gs-4060	519	18	,	,	PUNCT
gs-4060	519	19	protacs	protac	NOUN
gs-4060	519	20	are	be	AUX
gs-4060	519	21	heterobifunctional	heterobifunctional	ADJ
gs-4060	519	22	molecules	molecule	NOUN
gs-4060	519	23	.	.	PUNCT
gs-4060	520	1	one	one	NUM
gs-4060	520	2	end	end	NOUN
gs-4060	520	3	binds	bind	VERB
gs-4060	520	4	to	to	ADP
gs-4060	520	5	the	the	DET
gs-4060	520	6	target	target	NOUN
gs-4060	520	7	protein	protein	NOUN
gs-4060	520	8	of	of	ADP
gs-4060	520	9	interest	interest	NOUN
gs-4060	520	10	,	,	PUNCT
gs-4060	520	11	while	while	SCONJ
gs-4060	520	12	the	the	DET
gs-4060	520	13	other	other	ADJ
gs-4060	520	14	end	end	NOUN
gs-4060	520	15	recruits	recruit	VERB
gs-4060	520	16	an	an	DET
gs-4060	520	17	e3	e3	NOUN
gs-4060	520	18	ubiquitin	ubiquitin	NOUN
gs-4060	520	19	ligase	ligase	NOUN
gs-4060	520	20	.	.	PUNCT
gs-4060	521	1	this	this	DET
gs-4060	521	2	forced	force	VERB
gs-4060	521	3	proximity	proximity	NOUN
gs-4060	521	4	facilitates	facilitate	VERB
gs-4060	521	5	the	the	DET
gs-4060	521	6	ubiquitination	ubiquitination	NOUN
gs-4060	521	7	of	of	ADP
gs-4060	521	8	the	the	DET
gs-4060	521	9	target	target	NOUN
gs-4060	521	10	protein	protein	NOUN
gs-4060	521	11	,	,	PUNCT
gs-4060	521	12	marking	mark	VERB
gs-4060	521	13	it	it	PRON
gs-4060	521	14	for	for	ADP
gs-4060	521	15	degradation	degradation	NOUN
gs-4060	521	16	by	by	ADP
gs-4060	521	17	the	the	DET
gs-4060	521	18	proteasome	proteasome	NOUN
gs-4060	521	19	.	.	PUNCT
gs-4060	522	1	this	this	DET
gs-4060	522	2	mechanism	mechanism	NOUN
gs-4060	522	3	offers	offer	VERB
gs-4060	522	4	several	several	ADJ
gs-4060	522	5	potential	potential	ADJ
gs-4060	522	6	advantages	advantage	NOUN
gs-4060	522	7	:	:	PUNCT
gs-4060	522	8	it	it	PRON
gs-4060	522	9	can	can	AUX
gs-4060	522	10	target	target	VERB
gs-4060	522	11	proteins	protein	NOUN
gs-4060	522	12	that	that	PRON
gs-4060	522	13	lack	lack	VERB
gs-4060	522	14	a	a	DET
gs-4060	522	15	defined	define	VERB
gs-4060	522	16	active	active	ADJ
gs-4060	522	17	site	site	NOUN
gs-4060	522	18	and	and	CCONJ
gs-4060	522	19	are	be	AUX
gs-4060	522	20	therefore	therefore	ADV
gs-4060	522	21	considered	consider	VERB
gs-4060	522	22	"	"	PUNCT
gs-4060	522	23	undruggable	undruggable	ADJ
gs-4060	522	24	"	"	PUNCT
gs-4060	522	25	by	by	ADP
gs-4060	522	26	conventional	conventional	ADJ
gs-4060	522	27	means	mean	NOUN
gs-4060	522	28	;	;	PUNCT
gs-4060	522	29	it	it	PRON
gs-4060	522	30	achieves	achieve	VERB
gs-4060	522	31	a	a	DET
gs-4060	522	32	more	more	ADV
gs-4060	522	33	complete	complete	ADJ
gs-4060	522	34	and	and	CCONJ
gs-4060	522	35	sustained	sustained	ADJ
gs-4060	522	36	ablation	ablation	NOUN
gs-4060	522	37	of	of	ADP
gs-4060	522	38	the	the	DET
gs-4060	522	39	target	target	NOUN
gs-4060	522	40	,	,	PUNCT
gs-4060	522	41	potentially	potentially	ADV
gs-4060	522	42	overcoming	overcome	VERB
gs-4060	522	43	resistance	resistance	NOUN
gs-4060	522	44	caused	cause	VERB
gs-4060	522	45	by	by	ADP
gs-4060	522	46	protein	protein	NOUN
gs-4060	522	47	overexpression	overexpression	NOUN
gs-4060	522	48	or	or	CCONJ
gs-4060	522	49	mutations	mutation	NOUN
gs-4060	522	50	that	that	PRON
gs-4060	522	51	reduce	reduce	VERB
gs-4060	522	52	drug	drug	NOUN
gs-4060	522	53	-	-	PUNCT
gs-4060	522	54	binding	bind	VERB
gs-4060	522	55	affinity	affinity	NOUN
gs-4060	522	56	;	;	PUNCT
gs-4060	522	57	and	and	CCONJ
gs-4060	522	58	it	it	PRON
gs-4060	522	59	operates	operate	VERB
gs-4060	522	60	catalytically	catalytically	ADV
gs-4060	522	61	,	,	PUNCT
gs-4060	522	62	meaning	mean	VERB
gs-4060	522	63	a	a	DET
gs-4060	522	64	single	single	ADJ
gs-4060	522	65	protac	protac	ADJ
gs-4060	522	66	molecule	molecule	NOUN
gs-4060	522	67	can	can	AUX
gs-4060	522	68	facilitate	facilitate	VERB
gs-4060	522	69	the	the	DET
gs-4060	522	70	degradation	degradation	NOUN
gs-4060	522	71	of	of	ADP
gs-4060	522	72	multiple	multiple	ADJ
gs-4060	522	73	target	target	NOUN
gs-4060	522	74	proteins	protein	NOUN
gs-4060	522	75	.	.	PUNCT
gs-4060	523	1	while	while	SCONJ
gs-4060	523	2	still	still	ADV
gs-4060	523	3	largely	largely	ADV
gs-4060	523	4	in	in	ADP
gs-4060	523	5	preclinical	preclinical	ADJ
gs-4060	523	6	and	and	CCONJ
gs-4060	523	7	early	early	ADJ
gs-4060	523	8	clinical	clinical	ADJ
gs-4060	523	9	development	development	NOUN
gs-4060	523	10	,	,	PUNCT
gs-4060	523	11	protacs	protac	NOUN
gs-4060	523	12	hold	hold	VERB
gs-4060	523	13	immense	immense	ADJ
gs-4060	523	14	potential	potential	NOUN
gs-4060	523	15	to	to	PART
gs-4060	523	16	significantly	significantly	ADV
gs-4060	523	17	expand	expand	VERB
gs-4060	523	18	the	the	DET
gs-4060	523	19	universe	universe	NOUN
gs-4060	523	20	of	of	ADP
gs-4060	523	21	druggable	druggable	ADJ
gs-4060	523	22	targets	target	NOUN
gs-4060	523	23	in	in	ADP
gs-4060	523	24	oncology	oncology	NOUN
gs-4060	523	25	.	.	PUNCT
gs-4060	524	1	another	another	DET
gs-4060	524	2	frontier	frontier	NOUN
gs-4060	524	3	is	be	AUX
gs-4060	524	4	the	the	DET
gs-4060	524	5	development	development	NOUN
gs-4060	524	6	of	of	ADP
gs-4060	524	7	radioligand	radioligand	NOUN
gs-4060	524	8	therapies	therapy	NOUN
gs-4060	524	9	,	,	PUNCT
gs-4060	524	10	which	which	PRON
gs-4060	524	11	combine	combine	VERB
gs-4060	524	12	the	the	DET
gs-4060	524	13	precision	precision	NOUN
gs-4060	524	14	of	of	ADP
gs-4060	524	15	targeted	target	VERB
gs-4060	524	16	delivery	delivery	NOUN
gs-4060	524	17	with	with	ADP
gs-4060	524	18	the	the	DET
gs-4060	524	19	potent	potent	ADJ
gs-4060	524	20	cell	cell	NOUN
gs-4060	524	21	-	-	PUNCT
gs-4060	524	22	killing	kill	VERB
gs-4060	524	23	power	power	NOUN
gs-4060	524	24	of	of	ADP
gs-4060	524	25	radiation	radiation	NOUN
gs-4060	524	26	.	.	PUNCT
gs-4060	525	1	this	this	DET
gs-4060	525	2	approach	approach	NOUN
gs-4060	525	3	involves	involve	VERB
gs-4060	525	4	a	a	DET
gs-4060	525	5	targeting	target	VERB
gs-4060	525	6	moiety	moiety	NOUN
gs-4060	525	7	(	(	PUNCT
gs-4060	525	8	often	often	ADV
gs-4060	525	9	a	a	DET
gs-4060	525	10	small	small	ADJ
gs-4060	525	11	molecule	molecule	NOUN
gs-4060	525	12	or	or	CCONJ
gs-4060	525	13	peptide	peptide	NOUN
gs-4060	525	14	)	)	PUNCT
gs-4060	525	15	that	that	PRON
gs-4060	525	16	binds	bind	VERB
gs-4060	525	17	with	with	ADP
gs-4060	525	18	high	high	ADJ
gs-4060	525	19	affinity	affinity	NOUN
gs-4060	525	20	to	to	ADP
gs-4060	525	21	a	a	DET
gs-4060	525	22	tumorassociated	tumorassociate	VERB
gs-4060	525	23	antigen	antigen	NOUN
gs-4060	525	24	,	,	PUNCT
gs-4060	525	25	linked	link	VERB
gs-4060	525	26	to	to	ADP
gs-4060	525	27	a	a	DET
gs-4060	525	28	radioactive	radioactive	ADJ
gs-4060	525	29	isotope	isotope	NOUN
gs-4060	525	30	.	.	PUNCT
gs-4060	526	1	the	the	DET
gs-4060	526	2	compound	compound	NOUN
gs-4060	526	3	is	be	AUX
gs-4060	526	4	administered	administer	VERB
gs-4060	526	5	systemically	systemically	ADV
gs-4060	526	6	,	,	PUNCT
gs-4060	526	7	hones	hone	NOUN
gs-4060	526	8	in	in	ADV
gs-4060	526	9	on	on	ADP
gs-4060	526	10	tumor	tumor	NOUN
gs-4060	526	11	cells	cell	NOUN
gs-4060	526	12	expressing	express	VERB
gs-4060	526	13	the	the	DET
gs-4060	526	14	target	target	NOUN
gs-4060	526	15	,	,	PUNCT
gs-4060	526	16	and	and	CCONJ
gs-4060	526	17	delivers	deliver	VERB
gs-4060	526	18	localized	localized	ADJ
gs-4060	526	19	radiation	radiation	NOUN
gs-4060	526	20	,	,	PUNCT
gs-4060	526	21	causing	cause	VERB
gs-4060	526	22	dna	dna	NOUN
gs-4060	526	23	damage	damage	NOUN
gs-4060	526	24	and	and	CCONJ
gs-4060	526	25	cell	cell	NOUN
gs-4060	526	26	death	death	NOUN
gs-4060	526	27	.	.	PUNCT
gs-4060	527	1	the	the	DET
gs-4060	527	2	recent	recent	ADJ
gs-4060	527	3	success	success	NOUN
gs-4060	527	4	of	of	ADP
gs-4060	527	5	lutetium-177	lutetium-177	ADJ
gs-4060	527	6	dotatate	dotatate	NOUN
gs-4060	527	7	for	for	ADP
gs-4060	527	8	neuroendocrine	neuroendocrine	ADJ
gs-4060	527	9	tumors	tumor	NOUN
gs-4060	527	10	and	and	CCONJ
gs-4060	527	11	lutetium-177	lutetium-177	ADJ
gs-4060	527	12	psma-617	psma-617	NOUN
gs-4060	527	13	for	for	ADP
gs-4060	527	14	metastatic	metastatic	ADJ
gs-4060	527	15	castration	castration	NOUN
gs-4060	527	16	-	-	PUNCT
gs-4060	527	17	resistant	resistant	ADJ
gs-4060	527	18	prostate	prostate	NOUN
gs-4060	527	19	cancer	cancer	NOUN
gs-4060	527	20	validates	validate	VERB
gs-4060	527	21	this	this	DET
gs-4060	527	22	platform	platform	NOUN
gs-4060	527	23	.	.	PUNCT
gs-4060	528	1	the	the	DET
gs-4060	528	2	"	"	PUNCT
gs-4060	528	3	crossfire	crossfire	NOUN
gs-4060	528	4	"	"	PUNCT
gs-4060	528	5	effect	effect	NOUN
gs-4060	528	6	of	of	ADP
gs-4060	528	7	radiation	radiation	NOUN
gs-4060	528	8	can	can	AUX
gs-4060	528	9	kill	kill	VERB
gs-4060	528	10	neighboring	neighboring	NOUN
gs-4060	528	11	tumor	tumor	NOUN
gs-4060	528	12	cells	cell	NOUN
gs-4060	528	13	that	that	PRON
gs-4060	528	14	may	may	AUX
gs-4060	528	15	not	not	PART
gs-4060	528	16	express	express	VERB
gs-4060	528	17	the	the	DET
gs-4060	528	18	target	target	NOUN
gs-4060	528	19	antigen	antigen	ADV
gs-4060	528	20	,	,	PUNCT
gs-4060	528	21	addressing	address	VERB
gs-4060	528	22	the	the	DET
gs-4060	528	23	challenge	challenge	NOUN
gs-4060	528	24	of	of	ADP
gs-4060	528	25	tumor	tumor	NOUN
gs-4060	528	26	heterogeneity	heterogeneity	NOUN
gs-4060	528	27	.	.	PUNCT
gs-4060	529	1	however	however	ADV
gs-4060	529	2	,	,	PUNCT
gs-4060	529	3	this	this	PRON
gs-4060	529	4	also	also	ADV
gs-4060	529	5	necessitates	necessitate	VERB
gs-4060	529	6	careful	careful	ADJ
gs-4060	529	7	dosimetry	dosimetry	NOUN
gs-4060	529	8	and	and	CCONJ
gs-4060	529	9	monitoring	monitoring	NOUN
gs-4060	529	10	to	to	PART
gs-4060	529	11	mitigate	mitigate	VERB
gs-4060	529	12	off	off	ADP
gs-4060	529	13	-	-	PUNCT
gs-4060	529	14	target	target	NOUN
gs-4060	529	15	radiation	radiation	NOUN
gs-4060	529	16	exposure	exposure	NOUN
gs-4060	529	17	to	to	ADP
gs-4060	529	18	critical	critical	ADJ
gs-4060	529	19	organs	organ	NOUN
gs-4060	529	20	,	,	PUNCT
gs-4060	529	21	particularly	particularly	ADV
gs-4060	529	22	the	the	DET
gs-4060	529	23	kidneys	kidney	NOUN
gs-4060	529	24	and	and	CCONJ
gs-4060	529	25	bone	bone	NOUN
gs-4060	529	26	marrow	marrow	NOUN
gs-4060	529	27	.	.	PUNCT
gs-4060	530	1	furthermore	furthermore	ADV
gs-4060	530	2	,	,	PUNCT
gs-4060	530	3	the	the	DET
gs-4060	530	4	field	field	NOUN
gs-4060	530	5	of	of	ADP
gs-4060	530	6	cancer	cancer	NOUN
gs-4060	530	7	vaccines	vaccine	NOUN
gs-4060	530	8	is	be	AUX
gs-4060	530	9	experiencing	experience	VERB
gs-4060	530	10	a	a	DET
gs-4060	530	11	renaissance	renaissance	NOUN
gs-4060	530	12	,	,	PUNCT
gs-4060	530	13	propelled	propel	VERB
gs-4060	530	14	by	by	ADP
gs-4060	530	15	mrna	mrna	PROPN
gs-4060	530	16	technology	technology	PROPN
gs-4060	530	17	.	.	PUNCT
gs-4060	531	1	unlike	unlike	ADP
gs-4060	531	2	preventive	preventive	ADJ
gs-4060	531	3	vaccines	vaccine	NOUN
gs-4060	531	4	,	,	PUNCT
gs-4060	531	5	therapeutic	therapeutic	ADJ
gs-4060	531	6	cancer	cancer	NOUN
gs-4060	531	7	vaccines	vaccine	NOUN
gs-4060	531	8	aim	aim	VERB
gs-4060	531	9	to	to	PART
gs-4060	531	10	stimulate	stimulate	VERB
gs-4060	531	11	a	a	DET
gs-4060	531	12	pre	pre	ADJ
gs-4060	531	13	-	-	ADJ
gs-4060	531	14	existing	existing	ADJ
gs-4060	531	15	immune	immune	ADJ
gs-4060	531	16	response	response	NOUN
gs-4060	531	17	or	or	CCONJ
gs-4060	531	18	initiate	initiate	VERB
gs-4060	531	19	a	a	DET
gs-4060	531	20	de	de	X
gs-4060	531	21	novo	novo	NOUN
gs-4060	531	22	response	response	NOUN
gs-4060	531	23	against	against	ADP
gs-4060	531	24	tumor	tumor	NOUN
gs-4060	531	25	-	-	PUNCT
gs-4060	531	26	specific	specific	ADJ
gs-4060	531	27	antigens	antigen	NOUN
gs-4060	531	28	.	.	PUNCT
gs-4060	532	1	mrna	mrna	PROPN
gs-4060	532	2	-	-	PUNCT
gs-4060	532	3	based	base	VERB
gs-4060	532	4	vaccines	vaccine	NOUN
gs-4060	532	5	offer	offer	VERB
gs-4060	532	6	compelling	compelling	ADJ
gs-4060	532	7	advantages	advantage	NOUN
gs-4060	532	8	:	:	PUNCT
gs-4060	532	9	they	they	PRON
gs-4060	532	10	are	be	AUX
gs-4060	532	11	highly	highly	ADV
gs-4060	532	12	specific	specific	ADJ
gs-4060	532	13	,	,	PUNCT
gs-4060	532	14	rapidly	rapidly	ADV
gs-4060	532	15	and	and	CCONJ
gs-4060	532	16	inexpensively	inexpensively	ADV
gs-4060	532	17	manufactured	manufacture	VERB
gs-4060	532	18	,	,	PUNCT
gs-4060	532	19	and	and	CCONJ
gs-4060	532	20	can	can	AUX
gs-4060	532	21	encode	encode	VERB
gs-4060	532	22	for	for	ADP
gs-4060	532	23	multiple	multiple	ADJ
gs-4060	532	24	neoantigens	neoantigen	NOUN
gs-4060	532	25	simultaneously	simultaneously	ADV
gs-4060	532	26	.	.	PUNCT
gs-4060	533	1	the	the	DET
gs-4060	533	2	recent	recent	ADJ
gs-4060	533	3	clinical	clinical	ADJ
gs-4060	533	4	validation	validation	NOUN
gs-4060	533	5	of	of	ADP
gs-4060	533	6	mrna	mrna	PROPN
gs-4060	533	7	technology	technology	PROPN
gs-4060	533	8	in	in	ADP
gs-4060	533	9	infectious	infectious	ADJ
gs-4060	533	10	diseases	disease	NOUN
gs-4060	533	11	has	have	AUX
gs-4060	533	12	accelerated	accelerate	VERB
gs-4060	533	13	its	its	PRON
gs-4060	533	14	application	application	NOUN
gs-4060	533	15	in	in	ADP
gs-4060	533	16	oncology	oncology	NOUN
gs-4060	533	17	.	.	PUNCT
gs-4060	534	1	personalized	personalize	VERB
gs-4060	534	2	neoantigen	neoantigen	PROPN
gs-4060	534	3	vaccines	vaccine	NOUN
gs-4060	534	4	,	,	PUNCT
gs-4060	534	5	created	create	VERB
gs-4060	534	6	by	by	ADP
gs-4060	534	7	sequencing	sequence	VERB
gs-4060	534	8	a	a	DET
gs-4060	534	9	patient	patient	NOUN
gs-4060	534	10	's	's	PART
gs-4060	534	11	tumor	tumor	NOUN
gs-4060	534	12	to	to	PART
gs-4060	534	13	identify	identify	VERB
gs-4060	534	14	unique	unique	ADJ
gs-4060	534	15	mutations	mutation	NOUN
gs-4060	534	16	and	and	CCONJ
gs-4060	534	17	then	then	ADV
gs-4060	534	18	manufacturing	manufacture	VERB
gs-4060	534	19	a	a	DET
gs-4060	534	20	vaccine	vaccine	NOUN
gs-4060	534	21	encoding	encode	VERB
gs-4060	534	22	for	for	ADP
gs-4060	534	23	those	those	DET
gs-4060	534	24	specific	specific	ADJ
gs-4060	534	25	neoantigens	neoantigen	NOUN
gs-4060	534	26	,	,	PUNCT
gs-4060	534	27	represent	represent	VERB
gs-4060	534	28	the	the	DET
gs-4060	534	29	ultimate	ultimate	ADJ
gs-4060	534	30	form	form	NOUN
gs-4060	534	31	of	of	ADP
gs-4060	534	32	personalized	personalized	ADJ
gs-4060	534	33	medicine	medicine	NOUN
gs-4060	534	34	.	.	PUNCT
gs-4060	535	1	when	when	SCONJ
gs-4060	535	2	combined	combine	VERB
gs-4060	535	3	with	with	ADP
gs-4060	535	4	checkpoint	checkpoint	NOUN
gs-4060	535	5	blockade	blockade	NOUN
gs-4060	535	6	,	,	PUNCT
gs-4060	535	7	these	these	DET
gs-4060	535	8	vaccines	vaccine	NOUN
gs-4060	535	9	georgian	georgian	NOUN
gs-4060	535	10	scientists/	scientists/	NUM
gs-4060	535	11	.	.	PUNCT
gs-4060	536	1	7	7	NUM
gs-4060	536	2	n	n	PRON
gs-4060	536	3	3	3	NUM
gs-4060	536	4	,	,	PUNCT
gs-4060	536	5	2025	2025	NUM
gs-4060	536	6	594	594	NUM
gs-4060	536	7	can	can	AUX
gs-4060	536	8	act	act	VERB
gs-4060	536	9	as	as	ADP
gs-4060	536	10	a	a	DET
gs-4060	536	11	catalyst	catalyst	NOUN
gs-4060	536	12	,	,	PUNCT
gs-4060	536	13	expanding	expand	VERB
gs-4060	536	14	and	and	CCONJ
gs-4060	536	15	directing	direct	VERB
gs-4060	536	16	a	a	DET
gs-4060	536	17	repertoire	repertoire	NOUN
gs-4060	536	18	of	of	ADP
gs-4060	536	19	t	t	PROPN
gs-4060	536	20	-	-	PUNCT
gs-4060	536	21	cells	cell	NOUN
gs-4060	536	22	specifically	specifically	ADV
gs-4060	536	23	against	against	ADP
gs-4060	536	24	the	the	DET
gs-4060	536	25	patient	patient	NOUN
gs-4060	536	26	’s	’s	PART
gs-4060	536	27	tumor	tumor	NOUN
gs-4060	536	28	,	,	PUNCT
gs-4060	536	29	potentially	potentially	ADV
gs-4060	536	30	overcoming	overcome	VERB
gs-4060	536	31	primary	primary	ADJ
gs-4060	536	32	resistance	resistance	NOUN
gs-4060	536	33	to	to	ADP
gs-4060	536	34	immunotherapy	immunotherapy	NOUN
gs-4060	536	35	.	.	PUNCT
gs-4060	537	1	the	the	DET
gs-4060	537	2	tumor	tumor	NOUN
gs-4060	537	3	microenvironment	microenvironment	NOUN
gs-4060	537	4	:	:	PUNCT
gs-4060	537	5	the	the	DET
gs-4060	537	6	next	next	ADJ
gs-4060	537	7	therapeutic	therapeutic	ADJ
gs-4060	537	8	battleground	battleground	NOUN
gs-4060	537	9	it	it	PRON
gs-4060	537	10	is	be	AUX
gs-4060	537	11	increasingly	increasingly	ADV
gs-4060	537	12	clear	clear	ADJ
gs-4060	537	13	that	that	SCONJ
gs-4060	537	14	a	a	DET
gs-4060	537	15	tumor	tumor	NOUN
gs-4060	537	16	is	be	AUX
gs-4060	537	17	not	not	PART
gs-4060	537	18	merely	merely	ADV
gs-4060	537	19	a	a	DET
gs-4060	537	20	mass	mass	NOUN
gs-4060	537	21	of	of	ADP
gs-4060	537	22	malignant	malignant	ADJ
gs-4060	537	23	cells	cell	NOUN
gs-4060	537	24	but	but	CCONJ
gs-4060	537	25	a	a	DET
gs-4060	537	26	complex	complex	ADJ
gs-4060	537	27	organ	organ	NOUN
gs-4060	537	28	,	,	PUNCT
gs-4060	537	29	or	or	CCONJ
gs-4060	537	30	"	"	PUNCT
gs-4060	537	31	ecosystem	ecosystem	NOUN
gs-4060	537	32	,	,	PUNCT
gs-4060	537	33	"	"	PUNCT
gs-4060	537	34	comprising	comprise	VERB
gs-4060	537	35	a	a	DET
gs-4060	537	36	diverse	diverse	ADJ
gs-4060	537	37	array	array	NOUN
gs-4060	537	38	of	of	ADP
gs-4060	537	39	non	non	ADJ
gs-4060	537	40	-	-	ADJ
gs-4060	537	41	malignant	malignant	ADJ
gs-4060	537	42	cells	cell	NOUN
gs-4060	537	43	,	,	PUNCT
gs-4060	537	44	signaling	signal	VERB
gs-4060	537	45	molecules	molecule	NOUN
gs-4060	537	46	,	,	PUNCT
gs-4060	537	47	and	and	CCONJ
gs-4060	537	48	extracellular	extracellular	ADJ
gs-4060	537	49	matrix	matrix	NOUN
gs-4060	537	50	that	that	PRON
gs-4060	537	51	constitute	constitute	VERB
gs-4060	537	52	the	the	DET
gs-4060	537	53	tumor	tumor	NOUN
gs-4060	537	54	microenvironment	microenvironment	NOUN
gs-4060	537	55	.	.	PUNCT
gs-4060	538	1	this	this	DET
gs-4060	538	2	microenvironment	microenvironment	NOUN
gs-4060	538	3	is	be	AUX
gs-4060	538	4	not	not	PART
gs-4060	538	5	a	a	DET
gs-4060	538	6	passive	passive	ADJ
gs-4060	538	7	bystander	bystander	NOUN
gs-4060	538	8	but	but	CCONJ
gs-4060	538	9	plays	play	VERB
gs-4060	538	10	an	an	DET
gs-4060	538	11	active	active	ADJ
gs-4060	538	12	and	and	CCONJ
gs-4060	538	13	often	often	ADV
gs-4060	538	14	suppressive	suppressive	ADJ
gs-4060	538	15	role	role	NOUN
gs-4060	538	16	in	in	ADP
gs-4060	538	17	tumor	tumor	NOUN
gs-4060	538	18	progression	progression	NOUN
gs-4060	538	19	and	and	CCONJ
gs-4060	538	20	therapy	therapy	NOUN
gs-4060	538	21	resistance	resistance	NOUN
gs-4060	538	22	,	,	PUNCT
gs-4060	538	23	making	make	VERB
gs-4060	538	24	it	it	PRON
gs-4060	538	25	a	a	DET
gs-4060	538	26	critical	critical	ADJ
gs-4060	538	27	therapeutic	therapeutic	ADJ
gs-4060	538	28	target	target	NOUN
gs-4060	538	29	.	.	PUNCT
gs-4060	539	1	a	a	DET
gs-4060	539	2	major	major	ADJ
gs-4060	539	3	cellular	cellular	ADJ
gs-4060	539	4	component	component	NOUN
gs-4060	539	5	of	of	ADP
gs-4060	539	6	the	the	DET
gs-4060	539	7	tme	tme	NOUN
gs-4060	539	8	is	be	AUX
gs-4060	539	9	cancer	cancer	NOUN
gs-4060	539	10	-	-	PUNCT
gs-4060	539	11	associated	associate	VERB
gs-4060	539	12	fibroblasts	fibroblast	NOUN
gs-4060	539	13	.	.	PUNCT
gs-4060	540	1	these	these	DET
gs-4060	540	2	activated	activate	VERB
gs-4060	540	3	fibroblasts	fibroblast	NOUN
gs-4060	540	4	are	be	AUX
gs-4060	540	5	co	co	VERB
gs-4060	540	6	-	-	VERB
gs-4060	540	7	opted	opt	VERB
gs-4060	540	8	by	by	ADP
gs-4060	540	9	the	the	DET
gs-4060	540	10	tumor	tumor	NOUN
gs-4060	540	11	to	to	PART
gs-4060	540	12	support	support	VERB
gs-4060	540	13	its	its	PRON
gs-4060	540	14	growth	growth	NOUN
gs-4060	540	15	.	.	PUNCT
gs-4060	541	1	they	they	PRON
gs-4060	541	2	secrete	secrete	VERB
gs-4060	541	3	factors	factor	NOUN
gs-4060	541	4	that	that	PRON
gs-4060	541	5	promote	promote	VERB
gs-4060	541	6	cancer	cancer	NOUN
gs-4060	541	7	cell	cell	NOUN
gs-4060	541	8	proliferation	proliferation	NOUN
gs-4060	541	9	,	,	PUNCT
gs-4060	541	10	remodel	remodel	VERB
gs-4060	541	11	the	the	DET
gs-4060	541	12	extracellular	extracellular	ADJ
gs-4060	541	13	matrix	matrix	NOUN
gs-4060	541	14	to	to	PART
gs-4060	541	15	create	create	VERB
gs-4060	541	16	a	a	DET
gs-4060	541	17	physical	physical	ADJ
gs-4060	541	18	barrier	barrier	NOUN
gs-4060	541	19	to	to	ADP
gs-4060	541	20	drug	drug	NOUN
gs-4060	541	21	penetration	penetration	NOUN
gs-4060	541	22	and	and	CCONJ
gs-4060	541	23	immune	immune	ADJ
gs-4060	541	24	cell	cell	NOUN
gs-4060	541	25	infiltration	infiltration	NOUN
gs-4060	541	26	,	,	PUNCT
gs-4060	541	27	and	and	CCONJ
gs-4060	541	28	secrete	secrete	NOUN
gs-4060	541	29	cytokines	cytokine	NOUN
gs-4060	541	30	that	that	SCONJ
gs-4060	541	31	directly	directly	ADV
gs-4060	541	32	suppress	suppress	VERB
gs-4060	541	33	immune	immune	ADJ
gs-4060	541	34	effector	effector	NOUN
gs-4060	541	35	functions	function	NOUN
gs-4060	541	36	.	.	PUNCT
gs-4060	542	1	strategies	strategy	NOUN
gs-4060	542	2	to	to	PART
gs-4060	542	3	target	target	VERB
gs-4060	542	4	cafs	cafs	NOUN
gs-4060	542	5	are	be	AUX
gs-4060	542	6	challenging	challenge	VERB
gs-4060	542	7	because	because	SCONJ
gs-4060	542	8	they	they	PRON
gs-4060	542	9	are	be	AUX
gs-4060	542	10	a	a	DET
gs-4060	542	11	heterogeneous	heterogeneous	ADJ
gs-4060	542	12	population	population	NOUN
gs-4060	542	13	with	with	ADP
gs-4060	542	14	both	both	CCONJ
gs-4060	542	15	tumor	tumor	NOUN
gs-4060	542	16	-	-	PUNCT
gs-4060	542	17	promoting	promote	VERB
gs-4060	542	18	and	and	CCONJ
gs-4060	542	19	tumor	tumor	NOUN
gs-4060	542	20	-	-	PUNCT
gs-4060	542	21	restraining	restraining	NOUN
gs-4060	542	22	subsets	subset	NOUN
gs-4060	542	23	;	;	PUNCT
gs-4060	542	24	indiscriminate	indiscriminate	ADJ
gs-4060	542	25	depletion	depletion	NOUN
gs-4060	542	26	may	may	AUX
gs-4060	542	27	therefore	therefore	ADV
gs-4060	542	28	be	be	AUX
gs-4060	542	29	counterproductive	counterproductive	ADJ
gs-4060	542	30	.	.	PUNCT
gs-4060	543	1	current	current	ADJ
gs-4060	543	2	research	research	NOUN
gs-4060	543	3	is	be	AUX
gs-4060	543	4	focused	focus	VERB
gs-4060	543	5	on	on	ADP
gs-4060	543	6	disrupting	disrupt	VERB
gs-4060	543	7	specific	specific	ADJ
gs-4060	543	8	pro	pro	ADJ
gs-4060	543	9	-	-	ADJ
gs-4060	543	10	tumorigenic	tumorigenic	ADJ
gs-4060	543	11	functions	function	NOUN
gs-4060	543	12	of	of	ADP
gs-4060	543	13	cafs	cafs	NOUN
gs-4060	543	14	,	,	PUNCT
gs-4060	543	15	such	such	ADJ
gs-4060	543	16	as	as	ADP
gs-4060	543	17	targeting	target	VERB
gs-4060	543	18	their	their	PRON
gs-4060	543	19	contractile	contractile	NOUN
gs-4060	543	20	machinery	machinery	NOUN
gs-4060	543	21	or	or	CCONJ
gs-4060	543	22	inhibiting	inhibit	VERB
gs-4060	543	23	the	the	DET
gs-4060	543	24	specific	specific	ADJ
gs-4060	543	25	signaling	signal	VERB
gs-4060	543	26	pathways	pathway	NOUN
gs-4060	543	27	they	they	PRON
gs-4060	543	28	use	use	VERB
gs-4060	543	29	to	to	PART
gs-4060	543	30	communicate	communicate	VERB
gs-4060	543	31	with	with	ADP
gs-4060	543	32	cancer	cancer	NOUN
gs-4060	543	33	and	and	CCONJ
gs-4060	543	34	immune	immune	ADJ
gs-4060	543	35	cells	cell	NOUN
gs-4060	543	36	.	.	PUNCT
gs-4060	544	1	the	the	DET
gs-4060	544	2	immune	immune	ADJ
gs-4060	544	3	contexture	contexture	NOUN
gs-4060	544	4	of	of	ADP
gs-4060	544	5	the	the	DET
gs-4060	544	6	tme	tme	NOUN
gs-4060	544	7	is	be	AUX
gs-4060	544	8	equally	equally	ADV
gs-4060	544	9	critical	critical	ADJ
gs-4060	544	10	.	.	PUNCT
gs-4060	545	1	beyond	beyond	ADP
gs-4060	545	2	the	the	DET
gs-4060	545	3	cytotoxic	cytotoxic	ADJ
gs-4060	545	4	t	t	PROPN
gs-4060	545	5	-	-	PUNCT
gs-4060	545	6	cells	cell	NOUN
gs-4060	545	7	and	and	CCONJ
gs-4060	545	8	checkpoint	checkpoint	NOUN
gs-4060	545	9	proteins	protein	NOUN
gs-4060	545	10	,	,	PUNCT
gs-4060	545	11	the	the	DET
gs-4060	545	12	tme	tme	NOUN
gs-4060	545	13	is	be	AUX
gs-4060	545	14	often	often	ADV
gs-4060	545	15	enriched	enrich	VERB
gs-4060	545	16	with	with	ADP
gs-4060	545	17	immunosuppressive	immunosuppressive	ADJ
gs-4060	545	18	myeloid	myeloid	ADJ
gs-4060	545	19	cells	cell	NOUN
gs-4060	545	20	,	,	PUNCT
gs-4060	545	21	such	such	ADJ
gs-4060	545	22	as	as	ADP
gs-4060	545	23	tumor	tumor	NOUN
gs-4060	545	24	-	-	PUNCT
gs-4060	545	25	associated	associate	VERB
gs-4060	545	26	macrophages	macrophage	NOUN
gs-4060	545	27	and	and	CCONJ
gs-4060	545	28	myeloid	myeloid	ADJ
gs-4060	545	29	-	-	PUNCT
gs-4060	545	30	derived	derive	VERB
gs-4060	545	31	suppressor	suppressor	NOUN
gs-4060	545	32	cells	cell	NOUN
gs-4060	545	33	.	.	PUNCT
gs-4060	546	1	these	these	DET
gs-4060	546	2	cells	cell	NOUN
gs-4060	546	3	secrete	secrete	VERB
gs-4060	546	4	a	a	DET
gs-4060	546	5	range	range	NOUN
gs-4060	546	6	of	of	ADP
gs-4060	546	7	immunosuppressive	immunosuppressive	ADJ
gs-4060	546	8	cytokines	cytokine	NOUN
gs-4060	546	9	like	like	ADP
gs-4060	546	10	il-10	il-10	PRON
gs-4060	546	11	and	and	CCONJ
gs-4060	546	12	tgf	tgf	PROPN
gs-4060	546	13	,	,	PUNCT
gs-4060	546	14	deplete	deplete	NOUN
gs-4060	546	15	essential	essential	ADJ
gs-4060	546	16	amino	amino	ADJ
gs-4060	546	17	acids	acid	NOUN
gs-4060	546	18	like	like	ADP
gs-4060	546	19	tryptophan	tryptophan	NOUN
gs-4060	546	20	via	via	ADP
gs-4060	546	21	ido	ido	NOUN
gs-4060	546	22	expression	expression	NOUN
gs-4060	546	23	,	,	PUNCT
gs-4060	546	24	and	and	CCONJ
gs-4060	546	25	express	express	VERB
gs-4060	546	26	checkpoint	checkpoint	NOUN
gs-4060	546	27	ligands	ligand	NOUN
gs-4060	546	28	themselves	themselves	PRON
gs-4060	546	29	,	,	PUNCT
gs-4060	546	30	creating	create	VERB
gs-4060	546	31	a	a	DET
gs-4060	546	32	multi	multi	ADJ
gs-4060	546	33	-	-	ADJ
gs-4060	546	34	faceted	faceted	ADJ
gs-4060	546	35	barrier	barrier	NOUN
gs-4060	546	36	to	to	ADP
gs-4060	546	37	an	an	DET
gs-4060	546	38	effective	effective	ADJ
gs-4060	546	39	anti	anti	ADJ
gs-4060	546	40	-	-	ADJ
gs-4060	546	41	tumor	tumor	ADJ
gs-4060	546	42	immune	immune	ADJ
gs-4060	546	43	response	response	NOUN
gs-4060	546	44	.	.	PUNCT
gs-4060	547	1	therapeutic	therapeutic	ADJ
gs-4060	547	2	efforts	effort	NOUN
gs-4060	547	3	are	be	AUX
gs-4060	547	4	underway	underway	ADJ
gs-4060	547	5	to	to	PART
gs-4060	547	6	reprogram	reprogram	VERB
gs-4060	547	7	these	these	DET
gs-4060	547	8	myeloid	myeloid	ADJ
gs-4060	547	9	cells	cell	NOUN
gs-4060	547	10	from	from	ADP
gs-4060	547	11	a	a	DET
gs-4060	547	12	pro	pro	ADJ
gs-4060	547	13	-	-	ADJ
gs-4060	547	14	tumor	tumor	ADJ
gs-4060	547	15	(	(	PUNCT
gs-4060	547	16	m2	m2	PROPN
gs-4060	547	17	)	)	PUNCT
gs-4060	547	18	to	to	ADP
gs-4060	547	19	an	an	DET
gs-4060	547	20	anti	anti	ADJ
gs-4060	547	21	-	-	ADJ
gs-4060	547	22	tumor	tumor	ADJ
gs-4060	547	23	(	(	PUNCT
gs-4060	547	24	m1	m1	NOUN
gs-4060	547	25	)	)	PUNCT
gs-4060	547	26	phenotype	phenotype	NOUN
gs-4060	547	27	,	,	PUNCT
gs-4060	547	28	to	to	PART
gs-4060	547	29	deplete	deplete	VERB
gs-4060	547	30	them	they	PRON
gs-4060	547	31	,	,	PUNCT
gs-4060	547	32	or	or	CCONJ
gs-4060	547	33	to	to	PART
gs-4060	547	34	block	block	VERB
gs-4060	547	35	their	their	PRON
gs-4060	547	36	immunosuppressive	immunosuppressive	ADJ
gs-4060	547	37	mechanisms	mechanism	NOUN
gs-4060	547	38	,	,	PUNCT
gs-4060	547	39	often	often	ADV
gs-4060	547	40	in	in	ADP
gs-4060	547	41	combination	combination	NOUN
gs-4060	547	42	with	with	ADP
gs-4060	547	43	t	t	NOUN
gs-4060	547	44	-	-	PUNCT
gs-4060	547	45	cell	cell	NOUN
gs-4060	547	46	-	-	PUNCT
gs-4060	547	47	directed	direct	VERB
gs-4060	547	48	immunotherapies	immunotherapy	NOUN
gs-4060	547	49	.	.	PUNCT
gs-4060	548	1	the	the	DET
gs-4060	548	2	physical	physical	ADJ
gs-4060	548	3	structure	structure	NOUN
gs-4060	548	4	of	of	ADP
gs-4060	548	5	the	the	DET
gs-4060	548	6	tme	tme	NOUN
gs-4060	548	7	also	also	ADV
gs-4060	548	8	presents	present	VERB
gs-4060	548	9	a	a	DET
gs-4060	548	10	hurdle	hurdle	NOUN
gs-4060	548	11	.	.	PUNCT
gs-4060	549	1	high	high	ADJ
gs-4060	549	2	interstitial	interstitial	ADJ
gs-4060	549	3	fluid	fluid	NOUN
gs-4060	549	4	pressure	pressure	NOUN
gs-4060	549	5	,	,	PUNCT
gs-4060	549	6	abnormal	abnormal	ADJ
gs-4060	549	7	and	and	CCONJ
gs-4060	549	8	compressed	compress	VERB
gs-4060	549	9	blood	blood	NOUN
gs-4060	549	10	vessels	vessel	NOUN
gs-4060	549	11	,	,	PUNCT
gs-4060	549	12	and	and	CCONJ
gs-4060	549	13	a	a	DET
gs-4060	549	14	dense	dense	ADJ
gs-4060	549	15	fibrotic	fibrotic	ADJ
gs-4060	549	16	matrix	matrix	NOUN
gs-4060	549	17	can	can	AUX
gs-4060	549	18	impede	impede	VERB
gs-4060	549	19	the	the	DET
gs-4060	549	20	delivery	delivery	NOUN
gs-4060	549	21	and	and	CCONJ
gs-4060	549	22	distribution	distribution	NOUN
gs-4060	549	23	of	of	ADP
gs-4060	549	24	therapeutic	therapeutic	ADJ
gs-4060	549	25	agents	agent	NOUN
gs-4060	549	26	,	,	PUNCT
gs-4060	549	27	both	both	DET
gs-4060	549	28	small	small	ADJ
gs-4060	549	29	molecules	molecule	NOUN
gs-4060	549	30	and	and	CCONJ
gs-4060	549	31	biologics	biologic	NOUN
gs-4060	549	32	,	,	PUNCT
gs-4060	549	33	to	to	ADP
gs-4060	549	34	the	the	DET
gs-4060	549	35	tumor	tumor	NOUN
gs-4060	549	36	core	core	NOUN
gs-4060	549	37	.	.	PUNCT
gs-4060	550	1	strategies	strategy	NOUN
gs-4060	550	2	to	to	PART
gs-4060	550	3	normalize	normalize	VERB
gs-4060	550	4	the	the	DET
gs-4060	550	5	tumor	tumor	NOUN
gs-4060	550	6	vasculature	vasculature	NOUN
gs-4060	550	7	,	,	PUNCT
gs-4060	550	8	such	such	ADJ
gs-4060	550	9	as	as	ADP
gs-4060	550	10	using	use	VERB
gs-4060	550	11	modified	modify	VERB
gs-4060	550	12	,	,	PUNCT
gs-4060	550	13	low	low	ADJ
gs-4060	550	14	-	-	PUNCT
gs-4060	550	15	dose	dose	NOUN
gs-4060	550	16	anti	anti	ADJ
gs-4060	550	17	-	-	ADJ
gs-4060	550	18	angiogenic	angiogenic	ADJ
gs-4060	550	19	therapy	therapy	NOUN
gs-4060	550	20	,	,	PUNCT
gs-4060	550	21	or	or	CCONJ
gs-4060	550	22	enzymes	enzyme	NOUN
gs-4060	550	23	that	that	PRON
gs-4060	550	24	degrade	degrade	VERB
gs-4060	550	25	the	the	DET
gs-4060	550	26	matrix	matrix	NOUN
gs-4060	550	27	,	,	PUNCT
gs-4060	550	28	like	like	ADP
gs-4060	550	29	hyaluronidase	hyaluronidase	ADV
gs-4060	550	30	,	,	PUNCT
gs-4060	550	31	are	be	AUX
gs-4060	550	32	being	be	AUX
gs-4060	550	33	explored	explore	VERB
gs-4060	550	34	to	to	PART
gs-4060	550	35	enhance	enhance	VERB
gs-4060	550	36	drug	drug	NOUN
gs-4060	550	37	delivery	delivery	NOUN
gs-4060	550	38	and	and	CCONJ
gs-4060	550	39	improve	improve	VERB
gs-4060	550	40	the	the	DET
gs-4060	550	41	efficacy	efficacy	NOUN
gs-4060	550	42	of	of	ADP
gs-4060	550	43	existing	exist	VERB
gs-4060	550	44	treatments	treatment	NOUN
gs-4060	550	45	.	.	PUNCT
gs-4060	551	1	the	the	DET
gs-4060	551	2	role	role	NOUN
gs-4060	551	3	of	of	ADP
gs-4060	551	4	artificial	artificial	ADJ
gs-4060	551	5	intelligence	intelligence	NOUN
gs-4060	551	6	and	and	CCONJ
gs-4060	551	7	big	big	ADJ
gs-4060	551	8	data	datum	NOUN
gs-4060	551	9	in	in	ADP
gs-4060	551	10	drug	drug	NOUN
gs-4060	551	11	discovery	discovery	NOUN
gs-4060	551	12	and	and	CCONJ
gs-4060	551	13	development	development	NOUN
gs-4060	551	14	the	the	DET
gs-4060	551	15	complexity	complexity	NOUN
gs-4060	551	16	of	of	ADP
gs-4060	551	17	modern	modern	ADJ
gs-4060	551	18	oncology	oncology	NOUN
gs-4060	551	19	,	,	PUNCT
gs-4060	551	20	with	with	ADP
gs-4060	551	21	its	its	PRON
gs-4060	551	22	vast	vast	ADJ
gs-4060	551	23	datasets	dataset	NOUN
gs-4060	551	24	from	from	ADP
gs-4060	551	25	genomics	genomic	NOUN
gs-4060	551	26	,	,	PUNCT
gs-4060	551	27	transcriptomics	transcriptomic	NOUN
gs-4060	551	28	,	,	PUNCT
gs-4060	551	29	proteomics	proteomic	NOUN
gs-4060	551	30	,	,	PUNCT
gs-4060	551	31	and	and	CCONJ
gs-4060	551	32	digital	digital	ADJ
gs-4060	551	33	pathology	pathology	NOUN
gs-4060	551	34	,	,	PUNCT
gs-4060	551	35	has	have	AUX
gs-4060	551	36	necessitated	necessitate	VERB
gs-4060	551	37	the	the	DET
gs-4060	551	38	adoption	adoption	NOUN
gs-4060	551	39	of	of	ADP
gs-4060	551	40	advanced	advanced	ADJ
gs-4060	551	41	computational	computational	ADJ
gs-4060	551	42	tools	tool	NOUN
gs-4060	551	43	.	.	PUNCT
gs-4060	552	1	artificial	artificial	ADJ
gs-4060	552	2	intelligence	intelligence	NOUN
gs-4060	552	3	and	and	CCONJ
gs-4060	552	4	machine	machine	NOUN
gs-4060	552	5	learning	learning	NOUN
gs-4060	552	6	are	be	AUX
gs-4060	552	7	now	now	ADV
gs-4060	552	8	being	be	AUX
gs-4060	552	9	integrated	integrate	VERB
gs-4060	552	10	into	into	ADP
gs-4060	552	11	every	every	DET
gs-4060	552	12	stage	stage	NOUN
gs-4060	552	13	of	of	ADP
gs-4060	552	14	the	the	DET
gs-4060	552	15	drug	drug	NOUN
gs-4060	552	16	development	development	NOUN
gs-4060	552	17	pipeline	pipeline	NOUN
gs-4060	552	18	,	,	PUNCT
gs-4060	552	19	accelerating	accelerate	VERB
gs-4060	552	20	discovery	discovery	NOUN
gs-4060	552	21	and	and	CCONJ
gs-4060	552	22	improving	improve	VERB
gs-4060	552	23	success	success	NOUN
gs-4060	552	24	rates	rate	NOUN
gs-4060	552	25	.	.	PUNCT
gs-4060	553	1	in	in	ADP
gs-4060	553	2	the	the	DET
gs-4060	553	3	early	early	ADJ
gs-4060	553	4	discovery	discovery	NOUN
gs-4060	553	5	phase	phase	NOUN
gs-4060	553	6	,	,	PUNCT
gs-4060	553	7	ai	ai	VERB
gs-4060	553	8	algorithms	algorithm	NOUN
gs-4060	553	9	can	can	AUX
gs-4060	553	10	analyze	analyze	VERB
gs-4060	553	11	massive	massive	ADJ
gs-4060	553	12	chemical	chemical	NOUN
gs-4060	553	13	libraries	library	NOUN
gs-4060	553	14	to	to	PART
gs-4060	553	15	predict	predict	VERB
gs-4060	553	16	novel	novel	ADJ
gs-4060	553	17	compounds	compound	NOUN
gs-4060	553	18	with	with	ADP
gs-4060	553	19	high	high	ADJ
gs-4060	553	20	binding	bind	VERB
gs-4060	553	21	affinity	affinity	NOUN
gs-4060	553	22	for	for	ADP
gs-4060	553	23	a	a	DET
gs-4060	553	24	target	target	NOUN
gs-4060	553	25	protein	protein	NOUN
gs-4060	553	26	,	,	PUNCT
gs-4060	553	27	significantly	significantly	ADV
gs-4060	553	28	shortening	shorten	VERB
gs-4060	553	29	the	the	DET
gs-4060	553	30	hitto	hitto	NOUN
gs-4060	553	31	-	-	PUNCT
gs-4060	553	32	lead	lead	NOUN
gs-4060	553	33	process	process	NOUN
gs-4060	553	34	.	.	PUNCT
gs-4060	554	1	natural	natural	ADJ
gs-4060	554	2	language	language	NOUN
gs-4060	554	3	processing	processing	NOUN
gs-4060	554	4	models	model	NOUN
gs-4060	554	5	can	can	AUX
gs-4060	554	6	scour	scour	VERB
gs-4060	554	7	the	the	DET
gs-4060	554	8	entirety	entirety	NOUN
gs-4060	554	9	of	of	ADP
gs-4060	554	10	published	publish	VERB
gs-4060	554	11	scientific	scientific	ADJ
gs-4060	554	12	literature	literature	NOUN
gs-4060	554	13	to	to	PART
gs-4060	554	14	identify	identify	VERB
gs-4060	554	15	previously	previously	ADV
gs-4060	554	16	unknown	unknown	ADJ
gs-4060	554	17	connections	connection	NOUN
gs-4060	554	18	between	between	ADP
gs-4060	554	19	genes	gene	NOUN
gs-4060	554	20	,	,	PUNCT
gs-4060	554	21	pathways	pathway	NOUN
gs-4060	554	22	,	,	PUNCT
gs-4060	554	23	and	and	CCONJ
gs-4060	554	24	diseases	disease	NOUN
gs-4060	554	25	,	,	PUNCT
gs-4060	554	26	georgian	georgian	NOUN
gs-4060	554	27	scientists/	scientists/	NUM
gs-4060	554	28	.	.	PUNCT
gs-4060	555	1	7	7	NUM
gs-4060	555	2	n	n	PRON
gs-4060	555	3	3	3	NUM
gs-4060	555	4	,	,	PUNCT
gs-4060	555	5	2025	2025	NUM
gs-4060	555	6	595	595	NUM
gs-4060	555	7	proposing	propose	VERB
gs-4060	555	8	novel	novel	ADJ
gs-4060	555	9	drug	drug	NOUN
gs-4060	555	10	targets	target	NOUN
gs-4060	555	11	.	.	PUNCT
gs-4060	556	1	furthermore	furthermore	ADV
gs-4060	556	2	,	,	PUNCT
gs-4060	556	3	ai	ai	VERB
gs-4060	556	4	can	can	AUX
gs-4060	556	5	design	design	VERB
gs-4060	556	6	optimal	optimal	ADJ
gs-4060	556	7	drug	drug	NOUN
gs-4060	556	8	combinations	combination	NOUN
gs-4060	556	9	by	by	ADP
gs-4060	556	10	modeling	model	VERB
gs-4060	556	11	complex	complex	ADJ
gs-4060	556	12	signaling	signal	VERB
gs-4060	556	13	networks	network	NOUN
gs-4060	556	14	and	and	CCONJ
gs-4060	556	15	predicting	predict	VERB
gs-4060	556	16	which	which	DET
gs-4060	556	17	simultaneous	simultaneous	ADJ
gs-4060	556	18	inhibitions	inhibition	NOUN
gs-4060	556	19	will	will	AUX
gs-4060	556	20	be	be	AUX
gs-4060	556	21	most	most	ADV
gs-4060	556	22	synergistic	synergistic	ADJ
gs-4060	556	23	and	and	CCONJ
gs-4060	556	24	least	least	ADJ
gs-4060	556	25	toxic	toxic	ADJ
gs-4060	556	26	.	.	PUNCT
gs-4060	557	1	in	in	ADP
gs-4060	557	2	clinical	clinical	ADJ
gs-4060	557	3	development	development	NOUN
gs-4060	557	4	,	,	PUNCT
gs-4060	557	5	ai	ai	AUX
gs-4060	557	6	is	be	AUX
gs-4060	557	7	transforming	transform	VERB
gs-4060	557	8	clinical	clinical	ADJ
gs-4060	557	9	trial	trial	NOUN
gs-4060	557	10	design	design	NOUN
gs-4060	557	11	and	and	CCONJ
gs-4060	557	12	patient	patient	ADJ
gs-4060	557	13	selection	selection	NOUN
gs-4060	557	14	.	.	PUNCT
gs-4060	558	1	machine	machine	NOUN
gs-4060	558	2	learning	learning	NOUN
gs-4060	558	3	models	model	NOUN
gs-4060	558	4	can	can	AUX
gs-4060	558	5	analyze	analyze	VERB
gs-4060	558	6	electronic	electronic	ADJ
gs-4060	558	7	health	health	NOUN
gs-4060	558	8	records	record	NOUN
gs-4060	558	9	and	and	CCONJ
gs-4060	558	10	biomarker	biomarker	VERB
gs-4060	558	11	data	datum	NOUN
gs-4060	558	12	to	to	PART
gs-4060	558	13	identify	identify	VERB
gs-4060	558	14	the	the	DET
gs-4060	558	15	patient	patient	ADJ
gs-4060	558	16	subpopulations	subpopulation	NOUN
gs-4060	558	17	most	most	ADV
gs-4060	558	18	likely	likely	ADJ
gs-4060	558	19	to	to	PART
gs-4060	558	20	respond	respond	VERB
gs-4060	558	21	to	to	ADP
gs-4060	558	22	an	an	DET
gs-4060	558	23	investigational	investigational	ADJ
gs-4060	558	24	therapy	therapy	NOUN
gs-4060	558	25	,	,	PUNCT
gs-4060	558	26	enabling	enable	VERB
gs-4060	558	27	smarter	smart	ADJ
gs-4060	558	28	,	,	PUNCT
gs-4060	558	29	smaller	small	ADJ
gs-4060	558	30	,	,	PUNCT
gs-4060	558	31	and	and	CCONJ
gs-4060	558	32	more	more	ADV
gs-4060	558	33	efficient	efficient	ADJ
gs-4060	558	34	basket	basket	NOUN
gs-4060	558	35	trials	trial	NOUN
gs-4060	558	36	.	.	PUNCT
gs-4060	559	1	this	this	DET
gs-4060	559	2	enrichment	enrichment	NOUN
gs-4060	559	3	strategy	strategy	NOUN
gs-4060	559	4	increases	increase	VERB
gs-4060	559	5	the	the	DET
gs-4060	559	6	probability	probability	NOUN
gs-4060	559	7	of	of	ADP
gs-4060	559	8	trial	trial	NOUN
gs-4060	559	9	success	success	NOUN
gs-4060	559	10	and	and	CCONJ
gs-4060	559	11	helps	help	VERB
gs-4060	559	12	deliver	deliver	VERB
gs-4060	559	13	the	the	DET
gs-4060	559	14	right	right	ADJ
gs-4060	559	15	drug	drug	NOUN
gs-4060	559	16	to	to	ADP
gs-4060	559	17	the	the	DET
gs-4060	559	18	right	right	ADJ
gs-4060	559	19	patient	patient	NOUN
gs-4060	559	20	faster	fast	ADV
gs-4060	559	21	.	.	PUNCT
gs-4060	560	1	ai	ai	AUX
gs-4060	560	2	-	-	PUNCT
gs-4060	560	3	powered	power	VERB
gs-4060	560	4	analysis	analysis	NOUN
gs-4060	560	5	of	of	ADP
gs-4060	560	6	radiological	radiological	ADJ
gs-4060	560	7	images	image	NOUN
gs-4060	560	8	can	can	AUX
gs-4060	560	9	provide	provide	VERB
gs-4060	560	10	more	more	ADV
gs-4060	560	11	precise	precise	ADJ
gs-4060	560	12	and	and	CCONJ
gs-4060	560	13	automated	automate	VERB
gs-4060	560	14	measurements	measurement	NOUN
gs-4060	560	15	of	of	ADP
gs-4060	560	16	tumor	tumor	NOUN
gs-4060	560	17	response	response	NOUN
gs-4060	560	18	,	,	PUNCT
gs-4060	560	19	moving	move	VERB
gs-4060	560	20	beyond	beyond	ADP
gs-4060	560	21	recist	recist	NOUN
gs-4060	560	22	criteria	criterion	NOUN
gs-4060	560	23	to	to	PART
gs-4060	560	24	detect	detect	VERB
gs-4060	560	25	subtle	subtle	ADJ
gs-4060	560	26	changes	change	NOUN
gs-4060	560	27	in	in	ADP
gs-4060	560	28	tumor	tumor	NOUN
gs-4060	560	29	texture	texture	NOUN
gs-4060	560	30	and	and	CCONJ
gs-4060	560	31	density	density	NOUN
gs-4060	560	32	that	that	PRON
gs-4060	560	33	may	may	AUX
gs-4060	560	34	predict	predict	VERB
gs-4060	560	35	long	long	ADJ
gs-4060	560	36	-	-	PUNCT
gs-4060	560	37	term	term	NOUN
gs-4060	560	38	benefit	benefit	NOUN
gs-4060	560	39	earlier	early	ADV
gs-4060	560	40	than	than	ADP
gs-4060	560	41	standard	standard	ADJ
gs-4060	560	42	metrics	metric	NOUN
gs-4060	560	43	.	.	PUNCT
gs-4060	561	1	perhaps	perhaps	ADV
gs-4060	561	2	most	most	ADV
gs-4060	561	3	profoundly	profoundly	ADV
gs-4060	561	4	,	,	PUNCT
gs-4060	561	5	ai	ai	VERB
gs-4060	561	6	is	be	AUX
gs-4060	561	7	enabling	enable	VERB
gs-4060	561	8	the	the	DET
gs-4060	561	9	synthesis	synthesis	NOUN
gs-4060	561	10	of	of	ADP
gs-4060	561	11	multi	multi	ADJ
gs-4060	561	12	-	-	ADJ
gs-4060	561	13	omic	omic	ADJ
gs-4060	561	14	data	datum	NOUN
gs-4060	561	15	to	to	PART
gs-4060	561	16	generate	generate	VERB
gs-4060	561	17	a	a	DET
gs-4060	561	18	holistic	holistic	ADJ
gs-4060	561	19	view	view	NOUN
gs-4060	561	20	of	of	ADP
gs-4060	561	21	an	an	DET
gs-4060	561	22	individual	individual	NOUN
gs-4060	561	23	’s	’s	PART
gs-4060	561	24	cancer	cancer	NOUN
gs-4060	561	25	.	.	PUNCT
gs-4060	562	1	by	by	ADP
gs-4060	562	2	integrating	integrate	VERB
gs-4060	562	3	genomic	genomic	NOUN
gs-4060	562	4	,	,	PUNCT
gs-4060	562	5	transcriptomic	transcriptomic	ADJ
gs-4060	562	6	,	,	PUNCT
gs-4060	562	7	and	and	CCONJ
gs-4060	562	8	proteomic	proteomic	ADJ
gs-4060	562	9	data	datum	NOUN
gs-4060	562	10	from	from	ADP
gs-4060	562	11	a	a	DET
gs-4060	562	12	tumor	tumor	NOUN
gs-4060	562	13	biopsy	biopsy	NOUN
gs-4060	562	14	,	,	PUNCT
gs-4060	562	15	ml	ml	ADP
gs-4060	562	16	models	model	NOUN
gs-4060	562	17	can	can	AUX
gs-4060	562	18	predict	predict	VERB
gs-4060	562	19	disease	disease	NOUN
gs-4060	562	20	trajectory	trajectory	NOUN
gs-4060	562	21	,	,	PUNCT
gs-4060	562	22	resistance	resistance	NOUN
gs-4060	562	23	mechanisms	mechanism	NOUN
gs-4060	562	24	,	,	PUNCT
gs-4060	562	25	and	and	CCONJ
gs-4060	562	26	optimal	optimal	ADJ
gs-4060	562	27	.	.	PUNCT
gs-4060	563	1	decoding	decode	VERB
gs-4060	563	2	and	and	CCONJ
gs-4060	563	3	overcoming	overcome	VERB
gs-4060	563	4	therapeutic	therapeutic	ADJ
gs-4060	563	5	resistance	resistance	NOUN
gs-4060	563	6	:	:	PUNCT
gs-4060	563	7	a	a	DET
gs-4060	563	8	systems	system	NOUN
gs-4060	563	9	biology	biology	NOUN
gs-4060	563	10	approach	approach	NOUN
gs-4060	563	11	despite	despite	SCONJ
gs-4060	563	12	the	the	DET
gs-4060	563	13	initial	initial	ADJ
gs-4060	563	14	efficacy	efficacy	NOUN
gs-4060	563	15	of	of	ADP
gs-4060	563	16	many	many	ADJ
gs-4060	563	17	novel	novel	ADJ
gs-4060	563	18	agents	agent	NOUN
gs-4060	563	19	,	,	PUNCT
gs-4060	563	20	the	the	DET
gs-4060	563	21	development	development	NOUN
gs-4060	563	22	of	of	ADP
gs-4060	563	23	resistance	resistance	NOUN
gs-4060	563	24	remains	remain	VERB
gs-4060	563	25	the	the	DET
gs-4060	563	26	most	most	ADV
gs-4060	563	27	formidable	formidable	ADJ
gs-4060	563	28	challenge	challenge	NOUN
gs-4060	563	29	in	in	ADP
gs-4060	563	30	oncology	oncology	NOUN
gs-4060	563	31	.	.	PUNCT
gs-4060	564	1	moving	move	VERB
gs-4060	564	2	beyond	beyond	ADP
gs-4060	564	3	cataloging	catalog	VERB
gs-4060	564	4	individual	individual	ADJ
gs-4060	564	5	resistance	resistance	NOUN
gs-4060	564	6	mechanisms	mechanism	NOUN
gs-4060	564	7	,	,	PUNCT
gs-4060	564	8	a	a	DET
gs-4060	564	9	systems	system	NOUN
gs-4060	564	10	biology	biology	NOUN
gs-4060	564	11	approach	approach	NOUN
gs-4060	564	12	is	be	AUX
gs-4060	564	13	essential	essential	ADJ
gs-4060	564	14	to	to	PART
gs-4060	564	15	understand	understand	VERB
gs-4060	564	16	the	the	DET
gs-4060	564	17	complex	complex	ADJ
gs-4060	564	18	,	,	PUNCT
gs-4060	564	19	adaptive	adaptive	ADJ
gs-4060	564	20	networks	network	NOUN
gs-4060	564	21	that	that	PRON
gs-4060	564	22	tumors	tumor	NOUN
gs-4060	564	23	employ	employ	VERB
gs-4060	564	24	to	to	PART
gs-4060	564	25	survive	survive	VERB
gs-4060	564	26	therapeutic	therapeutic	ADJ
gs-4060	564	27	assault	assault	NOUN
gs-4060	564	28	.	.	PUNCT
gs-4060	565	1	this	this	DET
gs-4060	565	2	perspective	perspective	NOUN
gs-4060	565	3	views	view	VERB
gs-4060	565	4	resistance	resistance	NOUN
gs-4060	565	5	not	not	PART
gs-4060	565	6	as	as	ADP
gs-4060	565	7	a	a	DET
gs-4060	565	8	simple	simple	ADJ
gs-4060	565	9	binary	binary	ADJ
gs-4060	565	10	switch	switch	NOUN
gs-4060	565	11	but	but	CCONJ
gs-4060	565	12	as	as	ADP
gs-4060	565	13	a	a	DET
gs-4060	565	14	dynamic	dynamic	ADJ
gs-4060	565	15	,	,	PUNCT
gs-4060	565	16	evolutionary	evolutionary	ADJ
gs-4060	565	17	process	process	NOUN
gs-4060	565	18	driven	drive	VERB
gs-4060	565	19	by	by	ADP
gs-4060	565	20	darwinian	darwinian	ADJ
gs-4060	565	21	selection	selection	NOUN
gs-4060	565	22	pressure	pressure	NOUN
gs-4060	565	23	within	within	ADP
gs-4060	565	24	the	the	DET
gs-4060	565	25	tumor	tumor	NOUN
gs-4060	565	26	ecosystem	ecosystem	NOUN
gs-4060	565	27	.	.	PUNCT
gs-4060	566	1	cellular	cellular	ADJ
gs-4060	566	2	plasticity	plasticity	NOUN
gs-4060	566	3	and	and	CCONJ
gs-4060	566	4	phenotypic	phenotypic	NOUN
gs-4060	566	5	switching	switching	NOUN
gs-4060	566	6	have	have	AUX
gs-4060	566	7	emerged	emerge	VERB
gs-4060	566	8	as	as	ADP
gs-4060	566	9	critical	critical	ADJ
gs-4060	566	10	,	,	PUNCT
gs-4060	566	11	non	non	ADJ
gs-4060	566	12	-	-	ADJ
gs-4060	566	13	mutational	mutational	ADJ
gs-4060	566	14	drivers	driver	NOUN
gs-4060	566	15	of	of	ADP
gs-4060	566	16	resistance	resistance	NOUN
gs-4060	566	17	.	.	PUNCT
gs-4060	567	1	under	under	ADP
gs-4060	567	2	the	the	DET
gs-4060	567	3	selective	selective	ADJ
gs-4060	567	4	pressure	pressure	NOUN
gs-4060	567	5	of	of	ADP
gs-4060	567	6	targeted	target	VERB
gs-4060	567	7	therapy	therapy	NOUN
gs-4060	567	8	,	,	PUNCT
gs-4060	567	9	cancer	cancer	NOUN
gs-4060	567	10	cells	cell	NOUN
gs-4060	567	11	can	can	AUX
gs-4060	567	12	undergo	undergo	VERB
gs-4060	567	13	dedifferentiation	dedifferentiation	NOUN
gs-4060	567	14	,	,	PUNCT
gs-4060	567	15	transitioning	transition	VERB
gs-4060	567	16	from	from	ADP
gs-4060	567	17	a	a	DET
gs-4060	567	18	more	more	ADV
gs-4060	567	19	mature	mature	ADJ
gs-4060	567	20	,	,	PUNCT
gs-4060	567	21	drug	drug	NOUN
gs-4060	567	22	-	-	PUNCT
gs-4060	567	23	sensitive	sensitive	ADJ
gs-4060	567	24	state	state	NOUN
gs-4060	567	25	to	to	ADP
gs-4060	567	26	a	a	DET
gs-4060	567	27	primitive	primitive	ADJ
gs-4060	567	28	,	,	PUNCT
gs-4060	567	29	stem	stem	NOUN
gs-4060	567	30	-	-	PUNCT
gs-4060	567	31	like	like	ADJ
gs-4060	567	32	state	state	NOUN
gs-4060	567	33	that	that	PRON
gs-4060	567	34	is	be	AUX
gs-4060	567	35	inherently	inherently	ADV
gs-4060	567	36	resistant	resistant	ADJ
gs-4060	567	37	.	.	PUNCT
gs-4060	568	1	this	this	PRON
gs-4060	568	2	is	be	AUX
gs-4060	568	3	frequently	frequently	ADV
gs-4060	568	4	observed	observe	VERB
gs-4060	568	5	in	in	ADP
gs-4060	568	6	cancers	cancer	NOUN
gs-4060	568	7	like	like	ADP
gs-4060	568	8	melanoma	melanoma	NOUN
gs-4060	568	9	and	and	CCONJ
gs-4060	568	10	lung	lung	NOUN
gs-4060	568	11	adenocarcinoma	adenocarcinoma	NOUN
gs-4060	568	12	treated	treat	VERB
gs-4060	568	13	with	with	ADP
gs-4060	568	14	kinase	kinase	PROPN
gs-4060	568	15	inhibitors	inhibitor	NOUN
gs-4060	568	16	,	,	PUNCT
gs-4060	568	17	where	where	SCONJ
gs-4060	568	18	a	a	DET
gs-4060	568	19	subset	subset	NOUN
gs-4060	568	20	of	of	ADP
gs-4060	568	21	cells	cell	NOUN
gs-4060	568	22	adopts	adopt	VERB
gs-4060	568	23	a	a	DET
gs-4060	568	24	slow	slow	ADV
gs-4060	568	25	-	-	PUNCT
gs-4060	568	26	cycling	cycling	NOUN
gs-4060	568	27	,	,	PUNCT
gs-4060	568	28	persistent	persistent	ADJ
gs-4060	568	29	state	state	NOUN
gs-4060	568	30	characterized	characterize	VERB
gs-4060	568	31	by	by	ADP
gs-4060	568	32	altered	alter	VERB
gs-4060	568	33	metabolic	metabolic	NOUN
gs-4060	568	34	dependencies	dependency	NOUN
gs-4060	568	35	and	and	CCONJ
gs-4060	568	36	upregulated	upregulated	ADJ
gs-4060	568	37	drug	drug	NOUN
gs-4060	568	38	efflux	efflux	NOUN
gs-4060	568	39	pumps	pump	NOUN
gs-4060	568	40	.	.	PUNCT
gs-4060	569	1	these	these	DET
gs-4060	569	2	"	"	PUNCT
gs-4060	569	3	persister	persister	ADJ
gs-4060	569	4	"	"	PUNCT
gs-4060	569	5	cells	cell	NOUN
gs-4060	569	6	are	be	AUX
gs-4060	569	7	not	not	PART
gs-4060	569	8	genetically	genetically	ADV
gs-4060	569	9	distinct	distinct	ADJ
gs-4060	569	10	but	but	CCONJ
gs-4060	569	11	lie	lie	VERB
gs-4060	569	12	dormant	dormant	ADJ
gs-4060	569	13	,	,	PUNCT
gs-4060	569	14	serving	serve	VERB
gs-4060	569	15	as	as	ADP
gs-4060	569	16	a	a	DET
gs-4060	569	17	reservoir	reservoir	NOUN
gs-4060	569	18	from	from	ADP
gs-4060	569	19	which	which	PRON
gs-4060	569	20	resistant	resistant	ADJ
gs-4060	569	21	clones	clone	NOUN
gs-4060	569	22	eventually	eventually	ADV
gs-4060	569	23	emerge	emerge	VERB
gs-4060	569	24	.	.	PUNCT
gs-4060	570	1	similarly	similarly	ADV
gs-4060	570	2	,	,	PUNCT
gs-4060	570	3	under	under	ADP
gs-4060	570	4	immune	immune	ADJ
gs-4060	570	5	pressure	pressure	NOUN
gs-4060	570	6	,	,	PUNCT
gs-4060	570	7	cancer	cancer	NOUN
gs-4060	570	8	cells	cell	NOUN
gs-4060	570	9	can	can	AUX
gs-4060	570	10	undergo	undergo	VERB
gs-4060	570	11	immunoediting	immunoediting	NOUN
gs-4060	570	12	,	,	PUNCT
gs-4060	570	13	downregulating	downregulate	VERB
gs-4060	570	14	the	the	DET
gs-4060	570	15	very	very	ADJ
gs-4060	570	16	antigens	antigen	NOUN
gs-4060	570	17	and	and	CCONJ
gs-4060	570	18	antigen	antigen	NOUN
gs-4060	570	19	-	-	PUNCT
gs-4060	570	20	presenting	present	VERB
gs-4060	570	21	machinery	machinery	NOUN
gs-4060	570	22	that	that	PRON
gs-4060	570	23	make	make	VERB
gs-4060	570	24	them	they	PRON
gs-4060	570	25	visible	visible	ADJ
gs-4060	570	26	to	to	ADP
gs-4060	570	27	the	the	DET
gs-4060	570	28	immune	immune	ADJ
gs-4060	570	29	system	system	NOUN
gs-4060	570	30	,	,	PUNCT
gs-4060	570	31	effectively	effectively	ADV
gs-4060	570	32	becoming	become	VERB
gs-4060	570	33	"	"	PUNCT
gs-4060	570	34	invisible	invisible	ADJ
gs-4060	570	35	"	"	PUNCT
gs-4060	570	36	to	to	PART
gs-4060	570	37	car	car	NOUN
gs-4060	570	38	t	t	NOUN
gs-4060	570	39	-	-	PUNCT
gs-4060	570	40	cells	cell	NOUN
gs-4060	570	41	and	and	CCONJ
gs-4060	570	42	vaccineprimed	vaccineprime	VERB
gs-4060	570	43	t	t	PROPN
gs-4060	570	44	-	-	PUNCT
gs-4060	570	45	cells	cell	NOUN
gs-4060	570	46	.	.	PUNCT
gs-4060	571	1	targeting	target	VERB
gs-4060	571	2	this	this	DET
gs-4060	571	3	plasticity	plasticity	NOUN
gs-4060	571	4	requires	require	VERB
gs-4060	571	5	therapies	therapy	NOUN
gs-4060	571	6	that	that	SCONJ
gs-4060	571	7	lock	lock	NOUN
gs-4060	571	8	cells	cell	NOUN
gs-4060	571	9	into	into	ADP
gs-4060	571	10	a	a	DET
gs-4060	571	11	differentiated	differentiated	ADJ
gs-4060	571	12	,	,	PUNCT
gs-4060	571	13	susceptible	susceptible	ADJ
gs-4060	571	14	state	state	NOUN
gs-4060	571	15	or	or	CCONJ
gs-4060	571	16	that	that	PRON
gs-4060	571	17	specifically	specifically	ADV
gs-4060	571	18	target	target	VERB
gs-4060	571	19	the	the	DET
gs-4060	571	20	resistant	resistant	ADJ
gs-4060	571	21	stem	stem	NOUN
gs-4060	571	22	-	-	PUNCT
gs-4060	571	23	like	like	ADJ
gs-4060	571	24	population	population	NOUN
gs-4060	571	25	.	.	PUNCT
gs-4060	572	1	the	the	DET
gs-4060	572	2	concept	concept	NOUN
gs-4060	572	3	of	of	ADP
gs-4060	572	4	"	"	PUNCT
gs-4060	572	5	bet	bet	ADJ
gs-4060	572	6	-	-	PUNCT
gs-4060	572	7	hedging	hedging	NOUN
gs-4060	572	8	"	"	PUNCT
gs-4060	572	9	illustrates	illustrate	VERB
gs-4060	572	10	the	the	DET
gs-4060	572	11	tumor	tumor	NOUN
gs-4060	572	12	's	's	PART
gs-4060	572	13	intrinsic	intrinsic	ADJ
gs-4060	572	14	resilience	resilience	NOUN
gs-4060	572	15	.	.	PUNCT
gs-4060	573	1	a	a	DET
gs-4060	573	2	single	single	ADJ
gs-4060	573	3	tumor	tumor	NOUN
gs-4060	573	4	is	be	AUX
gs-4060	573	5	not	not	PART
gs-4060	573	6	a	a	DET
gs-4060	573	7	monolithic	monolithic	ADJ
gs-4060	573	8	entity	entity	NOUN
gs-4060	573	9	but	but	CCONJ
gs-4060	573	10	a	a	DET
gs-4060	573	11	collection	collection	NOUN
gs-4060	573	12	of	of	ADP
gs-4060	573	13	subclones	subclone	NOUN
gs-4060	573	14	with	with	ADP
gs-4060	573	15	diverse	diverse	ADJ
gs-4060	573	16	genetic	genetic	ADJ
gs-4060	573	17	and	and	CCONJ
gs-4060	573	18	phenotypic	phenotypic	ADJ
gs-4060	573	19	profiles	profile	NOUN
gs-4060	573	20	.	.	PUNCT
gs-4060	574	1	even	even	ADV
gs-4060	574	2	before	before	SCONJ
gs-4060	574	3	treatment	treatment	NOUN
gs-4060	574	4	begins	begin	VERB
gs-4060	574	5	,	,	PUNCT
gs-4060	574	6	a	a	DET
gs-4060	574	7	minor	minor	ADJ
gs-4060	574	8	subpopulation	subpopulation	NOUN
gs-4060	574	9	with	with	ADP
gs-4060	574	10	inherent	inherent	ADJ
gs-4060	574	11	resistance	resistance	NOUN
gs-4060	574	12	mechanisms	mechanism	NOUN
gs-4060	574	13	may	may	AUX
gs-4060	574	14	exist	exist	VERB
gs-4060	574	15	.	.	PUNCT
gs-4060	575	1	therapies	therapy	NOUN
gs-4060	575	2	that	that	PRON
gs-4060	575	3	are	be	AUX
gs-4060	575	4	cytostatic	cytostatic	ADJ
gs-4060	575	5	rather	rather	ADV
gs-4060	575	6	than	than	ADP
gs-4060	575	7	cytocidal	cytocidal	NOUN
gs-4060	575	8	exert	exert	VERB
gs-4060	575	9	a	a	DET
gs-4060	575	10	powerful	powerful	ADJ
gs-4060	575	11	selective	selective	ADJ
gs-4060	575	12	pressure	pressure	NOUN
gs-4060	575	13	that	that	PRON
gs-4060	575	14	favors	favor	VERB
gs-4060	575	15	the	the	DET
gs-4060	575	16	expansion	expansion	NOUN
gs-4060	575	17	of	of	ADP
gs-4060	575	18	these	these	DET
gs-4060	575	19	pre	pre	ADJ
gs-4060	575	20	-	-	ADJ
gs-4060	575	21	existing	exist	VERB
gs-4060	575	22	resistant	resistant	ADJ
gs-4060	575	23	clones	clone	NOUN
gs-4060	575	24	.	.	PUNCT
gs-4060	576	1	this	this	PRON
gs-4060	576	2	underscores	underscore	VERB
gs-4060	576	3	the	the	DET
gs-4060	576	4	critical	critical	ADJ
gs-4060	576	5	importance	importance	NOUN
gs-4060	576	6	of	of	ADP
gs-4060	576	7	combination	combination	NOUN
gs-4060	576	8	therapy	therapy	NOUN
gs-4060	576	9	upfront	upfront	NOUN
gs-4060	576	10	,	,	PUNCT
gs-4060	576	11	to	to	PART
gs-4060	576	12	achieve	achieve	VERB
gs-4060	576	13	a	a	DET
gs-4060	576	14	maximal	maximal	ADJ
gs-4060	576	15	cytotoxic	cytotoxic	ADJ
gs-4060	576	16	response	response	NOUN
gs-4060	576	17	that	that	PRON
gs-4060	576	18	obliterates	obliterate	VERB
gs-4060	576	19	the	the	DET
gs-4060	576	20	entire	entire	ADJ
gs-4060	576	21	tumor	tumor	NOUN
gs-4060	576	22	ecosystem	ecosystem	NOUN
gs-4060	576	23	before	before	SCONJ
gs-4060	576	24	adaptation	adaptation	NOUN
gs-4060	576	25	can	can	AUX
gs-4060	576	26	occur	occur	VERB
gs-4060	576	27	.	.	PUNCT
gs-4060	577	1	monitoring	monitor	VERB
gs-4060	577	2	for	for	ADP
gs-4060	577	3	the	the	DET
gs-4060	577	4	emergence	emergence	NOUN
gs-4060	577	5	of	of	ADP
gs-4060	577	6	these	these	DET
gs-4060	577	7	resistant	resistant	ADJ
gs-4060	577	8	clones	clone	NOUN
gs-4060	577	9	through	through	ADP
gs-4060	577	10	non	non	ADJ
gs-4060	577	11	-	-	ADJ
gs-4060	577	12	invasive	invasive	ADJ
gs-4060	577	13	liquid	liquid	ADJ
gs-4060	577	14	biopsies	biopsy	NOUN
gs-4060	577	15	,	,	PUNCT
gs-4060	577	16	which	which	PRON
gs-4060	577	17	track	track	VERB
gs-4060	577	18	circulating	circulate	VERB
gs-4060	577	19	tumor	tumor	NOUN
gs-4060	577	20	dna	dna	PROPN
gs-4060	577	21	,	,	PUNCT
gs-4060	577	22	is	be	AUX
gs-4060	577	23	becoming	become	VERB
gs-4060	577	24	a	a	DET
gs-4060	577	25	vital	vital	ADJ
gs-4060	577	26	georgian	georgian	NOUN
gs-4060	577	27	scientists/	scientists/	NUM
gs-4060	577	28	.	.	PUNCT
gs-4060	578	1	7	7	NUM
gs-4060	578	2	n	n	PRON
gs-4060	578	3	3	3	NUM
gs-4060	578	4	,	,	PUNCT
gs-4060	578	5	2025	2025	NUM
gs-4060	578	6	596	596	NUM
gs-4060	578	7	tool	tool	NOUN
gs-4060	578	8	in	in	ADP
gs-4060	578	9	clinical	clinical	ADJ
gs-4060	578	10	management	management	NOUN
gs-4060	578	11	,	,	PUNCT
gs-4060	578	12	allowing	allow	VERB
gs-4060	578	13	for	for	SCONJ
gs-4060	578	14	therapy	therapy	NOUN
gs-4060	578	15	to	to	PART
gs-4060	578	16	be	be	AUX
gs-4060	578	17	switched	switch	VERB
gs-4060	578	18	or	or	CCONJ
gs-4060	578	19	intensified	intensify	VERB
gs-4060	578	20	at	at	ADP
gs-4060	578	21	the	the	DET
gs-4060	578	22	earliest	early	ADJ
gs-4060	578	23	sign	sign	NOUN
gs-4060	578	24	of	of	ADP
gs-4060	578	25	clonal	clonal	ADJ
gs-4060	578	26	evolution	evolution	NOUN
gs-4060	578	27	.	.	PUNCT
gs-4060	579	1	the	the	DET
gs-4060	579	2	tumor	tumor	NOUN
gs-4060	579	3	microenvironment	microenvironment	NOUN
gs-4060	579	4	acts	act	VERB
gs-4060	579	5	as	as	ADP
gs-4060	579	6	a	a	DET
gs-4060	579	7	sanctuary	sanctuary	ADJ
gs-4060	579	8	and	and	CCONJ
gs-4060	579	9	active	active	ADJ
gs-4060	579	10	instructor	instructor	NOUN
gs-4060	579	11	of	of	ADP
gs-4060	579	12	resistance	resistance	NOUN
gs-4060	579	13	.	.	PUNCT
gs-4060	580	1	hypoxic	hypoxic	ADJ
gs-4060	580	2	regions	region	NOUN
gs-4060	580	3	within	within	ADP
gs-4060	580	4	the	the	DET
gs-4060	580	5	tumor	tumor	NOUN
gs-4060	580	6	,	,	PUNCT
gs-4060	580	7	far	far	ADV
gs-4060	580	8	from	from	ADP
gs-4060	580	9	functional	functional	ADJ
gs-4060	580	10	blood	blood	NOUN
gs-4060	580	11	vessels	vessel	NOUN
gs-4060	580	12	,	,	PUNCT
gs-4060	580	13	are	be	AUX
gs-4060	580	14	not	not	PART
gs-4060	580	15	only	only	ADV
gs-4060	580	16	ical	ical	ADJ
gs-4060	580	17	barriers	barrier	NOUN
gs-4060	580	18	to	to	ADP
gs-4060	580	19	drug	drug	NOUN
gs-4060	580	20	delivery	delivery	NOUN
gs-4060	580	21	but	but	CCONJ
gs-4060	580	22	also	also	ADV
gs-4060	580	23	create	create	VERB
gs-4060	580	24	niches	niche	NOUN
gs-4060	580	25	where	where	SCONJ
gs-4060	580	26	low	low	ADJ
gs-4060	580	27	oxygen	oxygen	NOUN
gs-4060	580	28	tension	tension	NOUN
gs-4060	580	29	induces	induce	VERB
gs-4060	580	30	a	a	DET
gs-4060	580	31	quiescent	quiescent	ADJ
gs-4060	580	32	,	,	PUNCT
gs-4060	580	33	therapyresistant	therapyresistant	ADJ
gs-4060	580	34	cell	cell	NOUN
gs-4060	580	35	state	state	NOUN
gs-4060	580	36	and	and	CCONJ
gs-4060	580	37	upregulates	upregulate	VERB
gs-4060	580	38	pro	pro	ADJ
gs-4060	580	39	-	-	ADJ
gs-4060	580	40	survival	survival	ADJ
gs-4060	580	41	pathways	pathway	NOUN
gs-4060	580	42	.	.	PUNCT
gs-4060	581	1	furthermore	furthermore	ADV
gs-4060	581	2	,	,	PUNCT
gs-4060	581	3	non	non	ADJ
gs-4060	581	4	-	-	ADJ
gs-4060	581	5	malignant	malignant	ADJ
gs-4060	581	6	cells	cell	NOUN
gs-4060	581	7	in	in	ADP
gs-4060	581	8	the	the	DET
gs-4060	581	9	tme	tme	NOUN
gs-4060	581	10	can	can	AUX
gs-4060	581	11	provide	provide	VERB
gs-4060	581	12	direct	direct	ADJ
gs-4060	581	13	survival	survival	NOUN
gs-4060	581	14	signals	signal	NOUN
gs-4060	581	15	to	to	ADP
gs-4060	581	16	cancer	cancer	NOUN
gs-4060	581	17	cells	cell	NOUN
gs-4060	581	18	.	.	PUNCT
gs-4060	582	1	for	for	ADP
gs-4060	582	2	example	example	NOUN
gs-4060	582	3	,	,	PUNCT
gs-4060	582	4	cancer	cancer	NOUN
gs-4060	582	5	-	-	PUNCT
gs-4060	582	6	associated	associate	VERB
gs-4060	582	7	fibroblasts	fibroblast	NOUN
gs-4060	582	8	can	can	AUX
gs-4060	582	9	secrete	secrete	VERB
gs-4060	582	10	growth	growth	NOUN
gs-4060	582	11	factors	factor	NOUN
gs-4060	582	12	like	like	ADP
gs-4060	582	13	hepatocyte	hepatocyte	NOUN
gs-4060	582	14	growth	growth	NOUN
gs-4060	582	15	factor	factor	NOUN
gs-4060	582	16	,	,	PUNCT
gs-4060	582	17	which	which	PRON
gs-4060	582	18	activates	activate	VERB
gs-4060	582	19	the	the	DET
gs-4060	582	20	met	meet	VERB
gs-4060	582	21	receptor	receptor	NOUN
gs-4060	582	22	on	on	ADP
gs-4060	582	23	cancer	cancer	NOUN
gs-4060	582	24	cells	cell	NOUN
gs-4060	582	25	and	and	CCONJ
gs-4060	582	26	provides	provide	VERB
gs-4060	582	27	a	a	DET
gs-4060	582	28	bypass	bypass	NOUN
gs-4060	582	29	signal	signal	NOUN
gs-4060	582	30	when	when	SCONJ
gs-4060	582	31	the	the	DET
gs-4060	582	32	primary	primary	ADJ
gs-4060	582	33	oncogenic	oncogenic	ADJ
gs-4060	582	34	driver	driver	NOUN
gs-4060	582	35	is	be	AUX
gs-4060	582	36	inhibited	inhibit	VERB
gs-4060	582	37	.	.	PUNCT
gs-4060	583	1	stromal	stromal	ADJ
gs-4060	583	2	cells	cell	NOUN
gs-4060	583	3	can	can	AUX
gs-4060	583	4	also	also	ADV
gs-4060	583	5	offer	offer	VERB
gs-4060	583	6	metabolic	metabolic	NOUN
gs-4060	583	7	support	support	NOUN
gs-4060	583	8	,	,	PUNCT
gs-4060	583	9	exporting	export	VERB
gs-4060	583	10	nutrients	nutrient	NOUN
gs-4060	583	11	that	that	PRON
gs-4060	583	12	rescue	rescue	NOUN
gs-4060	583	13	cancer	cancer	NOUN
gs-4060	583	14	cells	cell	NOUN
gs-4060	583	15	from	from	ADP
gs-4060	583	16	metabolic	metabolic	NOUN
gs-4060	583	17	stress	stress	NOUN
gs-4060	583	18	induced	induce	VERB
gs-4060	583	19	by	by	ADP
gs-4060	583	20	therapy	therapy	NOUN
gs-4060	583	21	.	.	PUNCT
gs-4060	584	1	therefore	therefore	ADV
gs-4060	584	2	,	,	PUNCT
gs-4060	584	3	effective	effective	ADJ
gs-4060	584	4	long	long	ADJ
gs-4060	584	5	-	-	PUNCT
gs-4060	584	6	term	term	NOUN
gs-4060	584	7	control	control	NOUN
gs-4060	584	8	of	of	ADP
gs-4060	584	9	cancer	cancer	NOUN
gs-4060	584	10	will	will	AUX
gs-4060	584	11	require	require	VERB
gs-4060	584	12	dualtargeting	dualtargeting	NOUN
gs-4060	584	13	strategies	strategy	NOUN
gs-4060	584	14	that	that	PRON
gs-4060	584	15	attack	attack	VERB
gs-4060	584	16	both	both	CCONJ
gs-4060	584	17	the	the	DET
gs-4060	584	18	cancer	cancer	NOUN
gs-4060	584	19	cells	cell	NOUN
gs-4060	584	20	and	and	CCONJ
gs-4060	584	21	the	the	DET
gs-4060	584	22	supportive	supportive	ADJ
gs-4060	584	23	,	,	PUNCT
gs-4060	584	24	resistance	resistance	NOUN
gs-4060	584	25	-	-	PUNCT
gs-4060	584	26	conferring	confer	VERB
gs-4060	584	27	niche	niche	NOUN
gs-4060	584	28	they	they	PRON
gs-4060	584	29	depend	depend	VERB
gs-4060	584	30	on	on	ADP
gs-4060	584	31	.	.	PUNCT
gs-4060	585	1	the	the	DET
gs-4060	585	2	oncobiota	oncobiota	NOUN
gs-4060	585	3	:	:	PUNCT
gs-4060	585	4	the	the	DET
gs-4060	585	5	human	human	ADJ
gs-4060	585	6	microbiome	microbiome	NOUN
gs-4060	585	7	as	as	ADP
gs-4060	585	8	a	a	DET
gs-4060	585	9	modulator	modulator	NOUN
gs-4060	585	10	of	of	ADP
gs-4060	585	11	therapy	therapy	NOUN
gs-4060	585	12	response	response	NOUN
gs-4060	585	13	a	a	DET
gs-4060	585	14	surprising	surprising	ADJ
gs-4060	585	15	and	and	CCONJ
gs-4060	585	16	revolutionary	revolutionary	ADJ
gs-4060	585	17	discovery	discovery	NOUN
gs-4060	585	18	in	in	ADP
gs-4060	585	19	modern	modern	ADJ
gs-4060	585	20	oncology	oncology	NOUN
gs-4060	585	21	is	be	AUX
gs-4060	585	22	the	the	DET
gs-4060	585	23	profound	profound	ADJ
gs-4060	585	24	influence	influence	NOUN
gs-4060	585	25	of	of	ADP
gs-4060	585	26	the	the	DET
gs-4060	585	27	human	human	ADJ
gs-4060	585	28	microbiome	microbiome	NOUN
gs-4060	585	29	,	,	PUNCT
gs-4060	585	30	particularly	particularly	ADV
gs-4060	585	31	the	the	DET
gs-4060	585	32	gut	gut	NOUN
gs-4060	585	33	microbiota	microbiota	NOUN
gs-4060	585	34	,	,	PUNCT
gs-4060	585	35	on	on	ADP
gs-4060	585	36	the	the	DET
gs-4060	585	37	efficacy	efficacy	NOUN
gs-4060	585	38	and	and	CCONJ
gs-4060	585	39	toxicity	toxicity	NOUN
gs-4060	585	40	of	of	ADP
gs-4060	585	41	anticancer	anticancer	NOUN
gs-4060	585	42	therapies	therapy	NOUN
gs-4060	585	43	.	.	PUNCT
gs-4060	586	1	the	the	DET
gs-4060	586	2	trillions	trillion	NOUN
gs-4060	586	3	of	of	ADP
gs-4060	586	4	bacteria	bacteria	NOUN
gs-4060	586	5	residing	reside	VERB
gs-4060	586	6	in	in	ADP
gs-4060	586	7	the	the	DET
gs-4060	586	8	gastrointestinal	gastrointestinal	ADJ
gs-4060	586	9	tract	tract	NOUN
gs-4060	586	10	are	be	AUX
gs-4060	586	11	no	no	ADV
gs-4060	586	12	longer	long	ADV
gs-4060	586	13	seen	see	VERB
gs-4060	586	14	as	as	ADP
gs-4060	586	15	passive	passive	ADJ
gs-4060	586	16	inhabitants	inhabitant	NOUN
gs-4060	586	17	but	but	CCONJ
gs-4060	586	18	as	as	ADP
gs-4060	586	19	active	active	ADJ
gs-4060	586	20	participants	participant	NOUN
gs-4060	586	21	in	in	ADP
gs-4060	586	22	pharmacology	pharmacology	NOUN
gs-4060	586	23	,	,	PUNCT
gs-4060	586	24	fundamentally	fundamentally	ADV
gs-4060	586	25	altering	alter	VERB
gs-4060	586	26	treatment	treatment	NOUN
gs-4060	586	27	outcomes	outcome	NOUN
gs-4060	586	28	.	.	PUNCT
gs-4060	587	1	the	the	DET
gs-4060	587	2	impact	impact	NOUN
gs-4060	587	3	on	on	ADP
gs-4060	587	4	immunotherapy	immunotherapy	NOUN
gs-4060	587	5	is	be	AUX
gs-4060	587	6	most	most	ADV
gs-4060	587	7	striking	striking	ADJ
gs-4060	587	8	.	.	PUNCT
gs-4060	588	1	a	a	DET
gs-4060	588	2	compelling	compelling	ADJ
gs-4060	588	3	body	body	NOUN
gs-4060	588	4	of	of	ADP
gs-4060	588	5	evidence	evidence	NOUN
gs-4060	588	6	from	from	ADP
gs-4060	588	7	preclinical	preclinical	ADJ
gs-4060	588	8	models	model	NOUN
gs-4060	588	9	and	and	CCONJ
gs-4060	588	10	human	human	ADJ
gs-4060	588	11	studies	study	NOUN
gs-4060	588	12	has	have	AUX
gs-4060	588	13	demonstrated	demonstrate	VERB
gs-4060	588	14	that	that	SCONJ
gs-4060	588	15	the	the	DET
gs-4060	588	16	composition	composition	NOUN
gs-4060	588	17	of	of	ADP
gs-4060	588	18	the	the	DET
gs-4060	588	19	gut	gut	NOUN
gs-4060	588	20	microbiome	microbiome	NOUN
gs-4060	588	21	can	can	AUX
gs-4060	588	22	predict	predict	VERB
gs-4060	588	23	response	response	NOUN
gs-4060	588	24	to	to	ADP
gs-4060	588	25	immune	immune	ADJ
gs-4060	588	26	checkpoint	checkpoint	NOUN
gs-4060	588	27	inhibitors	inhibitor	NOUN
gs-4060	588	28	.	.	PUNCT
gs-4060	589	1	patients	patient	NOUN
gs-4060	589	2	with	with	ADP
gs-4060	589	3	a	a	DET
gs-4060	589	4	more	more	ADV
gs-4060	589	5	diverse	diverse	ADJ
gs-4060	589	6	microbiome	microbiome	NOUN
gs-4060	589	7	enriched	enrich	VERB
gs-4060	589	8	in	in	ADP
gs-4060	589	9	specific	specific	ADJ
gs-4060	589	10	bacterial	bacterial	ADJ
gs-4060	589	11	taxa	taxa	NOUN
gs-4060	589	12	,	,	PUNCT
gs-4060	589	13	such	such	ADJ
gs-4060	589	14	as	as	ADP
gs-4060	589	15	faecalibacterium	faecalibacterium	NOUN
gs-4060	589	16	prausnitzii	prausnitzii	NOUN
gs-4060	589	17	and	and	CCONJ
gs-4060	589	18	akkermansia	akkermansia	PROPN
gs-4060	589	19	muciniphila	muciniphila	NOUN
gs-4060	589	20	,	,	PUNCT
gs-4060	589	21	exhibit	exhibit	VERB
gs-4060	589	22	significantly	significantly	ADV
gs-4060	589	23	higher	high	ADJ
gs-4060	589	24	response	response	NOUN
gs-4060	589	25	rates	rate	NOUN
gs-4060	589	26	and	and	CCONJ
gs-4060	589	27	improved	improved	ADJ
gs-4060	589	28	survival	survival	NOUN
gs-4060	589	29	outcomes	outcome	NOUN
gs-4060	589	30	compared	compare	VERB
gs-4060	589	31	to	to	ADP
gs-4060	589	32	patients	patient	NOUN
gs-4060	589	33	with	with	ADP
gs-4060	589	34	a	a	DET
gs-4060	589	35	less	less	ADV
gs-4060	589	36	favorable	favorable	ADJ
gs-4060	589	37	microbial	microbial	ADJ
gs-4060	589	38	profile	profile	NOUN
gs-4060	589	39	.	.	PUNCT
gs-4060	590	1	the	the	DET
gs-4060	590	2	mechanisms	mechanism	NOUN
gs-4060	590	3	are	be	AUX
gs-4060	590	4	multifaceted	multifaceted	ADJ
gs-4060	590	5	:	:	PUNCT
gs-4060	590	6	certain	certain	ADJ
gs-4060	590	7	commensal	commensal	ADJ
gs-4060	590	8	bacteria	bacteria	NOUN
gs-4060	590	9	are	be	AUX
gs-4060	590	10	known	know	VERB
gs-4060	590	11	to	to	PART
gs-4060	590	12	stimulate	stimulate	VERB
gs-4060	590	13	the	the	DET
gs-4060	590	14	innate	innate	ADJ
gs-4060	590	15	immune	immune	ADJ
gs-4060	590	16	system	system	NOUN
gs-4060	590	17	,	,	PUNCT
gs-4060	590	18	leading	lead	VERB
gs-4060	590	19	to	to	ADP
gs-4060	590	20	enhanced	enhanced	ADJ
gs-4060	590	21	dendritic	dendritic	ADJ
gs-4060	590	22	cell	cell	NOUN
gs-4060	590	23	activation	activation	NOUN
gs-4060	590	24	and	and	CCONJ
gs-4060	590	25	improved	improved	ADJ
gs-4060	590	26	priming	priming	NOUN
gs-4060	590	27	of	of	ADP
gs-4060	590	28	tumor	tumor	NOUN
gs-4060	590	29	-	-	PUNCT
gs-4060	590	30	specific	specific	ADJ
gs-4060	590	31	t	t	NOUN
gs-4060	590	32	-	-	PUNCT
gs-4060	590	33	cells	cell	NOUN
gs-4060	590	34	.	.	PUNCT
gs-4060	591	1	others	other	NOUN
gs-4060	591	2	can	can	AUX
gs-4060	591	3	metabolize	metabolize	VERB
gs-4060	591	4	dietary	dietary	ADJ
gs-4060	591	5	fibers	fiber	NOUN
gs-4060	591	6	into	into	ADP
gs-4060	591	7	short	short	ADJ
gs-4060	591	8	-	-	PUNCT
gs-4060	591	9	chain	chain	NOUN
gs-4060	591	10	fatty	fatty	NOUN
gs-4060	591	11	acids	acid	NOUN
gs-4060	591	12	like	like	ADP
gs-4060	591	13	butyrate	butyrate	NOUN
gs-4060	591	14	,	,	PUNCT
gs-4060	591	15	which	which	PRON
gs-4060	591	16	systemically	systemically	ADV
gs-4060	591	17	modulates	modulate	VERB
gs-4060	591	18	the	the	DET
gs-4060	591	19	immune	immune	ADJ
gs-4060	591	20	system	system	NOUN
gs-4060	591	21	,	,	PUNCT
gs-4060	591	22	reducing	reduce	VERB
gs-4060	591	23	inflammatory	inflammatory	ADJ
gs-4060	591	24	tone	tone	NOUN
gs-4060	591	25	and	and	CCONJ
gs-4060	591	26	enhancing	enhance	VERB
gs-4060	591	27	the	the	DET
gs-4060	591	28	function	function	NOUN
gs-4060	591	29	of	of	ADP
gs-4060	591	30	cytotoxic	cytotoxic	ADJ
gs-4060	591	31	t	t	PROPN
gs-4060	591	32	-	-	PUNCT
gs-4060	591	33	cells	cell	NOUN
gs-4060	591	34	within	within	ADP
gs-4060	591	35	the	the	DET
gs-4060	591	36	tumor	tumor	NOUN
gs-4060	591	37	microenvironment	microenvironment	NOUN
gs-4060	591	38	.	.	PUNCT
gs-4060	592	1	conversely	conversely	ADV
gs-4060	592	2	,	,	PUNCT
gs-4060	592	3	an	an	DET
gs-4060	592	4	unfavorable	unfavorable	ADJ
gs-4060	592	5	microbiome	microbiome	NOUN
gs-4060	592	6	,	,	PUNCT
gs-4060	592	7	or	or	CCONJ
gs-4060	592	8	dysbiosis	dysbiosis	NOUN
gs-4060	592	9	,	,	PUNCT
gs-4060	592	10	often	often	ADV
gs-4060	592	11	induced	induce	VERB
gs-4060	592	12	by	by	ADP
gs-4060	592	13	broad	broad	ADJ
gs-4060	592	14	-	-	PUNCT
gs-4060	592	15	spectrum	spectrum	NOUN
gs-4060	592	16	antibiotics	antibiotic	NOUN
gs-4060	592	17	,	,	PUNCT
gs-4060	592	18	is	be	AUX
gs-4060	592	19	consistently	consistently	ADV
gs-4060	592	20	associated	associate	VERB
gs-4060	592	21	with	with	ADP
gs-4060	592	22	poorer	poor	ADJ
gs-4060	592	23	outcomes	outcome	NOUN
gs-4060	592	24	to	to	ADP
gs-4060	592	25	immunotherapy	immunotherapy	NOUN
gs-4060	592	26	.	.	PUNCT
gs-4060	593	1	the	the	DET
gs-4060	593	2	microbiome	microbiome	NOUN
gs-4060	593	3	's	's	PART
gs-4060	593	4	influence	influence	NOUN
gs-4060	593	5	extends	extend	VERB
gs-4060	593	6	to	to	ADP
gs-4060	593	7	chemotherapeutic	chemotherapeutic	ADJ
gs-4060	593	8	and	and	CCONJ
gs-4060	593	9	targeted	targeted	ADJ
gs-4060	593	10	agents	agent	NOUN
gs-4060	593	11	.	.	PUNCT
gs-4060	594	1	numerous	numerous	ADJ
gs-4060	594	2	conventional	conventional	ADJ
gs-4060	594	3	chemotherapies	chemotherapy	NOUN
gs-4060	594	4	,	,	PUNCT
gs-4060	594	5	such	such	ADJ
gs-4060	594	6	as	as	ADP
gs-4060	594	7	cyclophosphamide	cyclophosphamide	NOUN
gs-4060	594	8	and	and	CCONJ
gs-4060	594	9	gemcitabine	gemcitabine	NOUN
gs-4060	594	10	,	,	PUNCT
gs-4060	594	11	rely	rely	VERB
gs-4060	594	12	on	on	ADP
gs-4060	594	13	the	the	DET
gs-4060	594	14	gut	gut	NOUN
gs-4060	594	15	microbiota	microbiota	NOUN
gs-4060	594	16	for	for	ADP
gs-4060	594	17	their	their	PRON
gs-4060	594	18	metabolic	metabolic	NOUN
gs-4060	594	19	activation	activation	NOUN
gs-4060	594	20	or	or	CCONJ
gs-4060	594	21	to	to	PART
gs-4060	594	22	stimulate	stimulate	VERB
gs-4060	594	23	supportive	supportive	ADJ
gs-4060	594	24	immune	immune	ADJ
gs-4060	594	25	responses	response	NOUN
gs-4060	594	26	.	.	PUNCT
gs-4060	595	1	bacteriaderived	bacteriaderive	VERB
gs-4060	595	2	enzymes	enzyme	NOUN
gs-4060	595	3	can	can	AUX
gs-4060	595	4	directly	directly	ADV
gs-4060	595	5	chemically	chemically	ADV
gs-4060	595	6	modify	modify	VERB
gs-4060	595	7	drugs	drug	NOUN
gs-4060	595	8	,	,	PUNCT
gs-4060	595	9	altering	alter	VERB
gs-4060	595	10	their	their	PRON
gs-4060	595	11	bioavailability	bioavailability	NOUN
gs-4060	595	12	,	,	PUNCT
gs-4060	595	13	efficacy	efficacy	NOUN
gs-4060	595	14	,	,	PUNCT
gs-4060	595	15	and	and	CCONJ
gs-4060	595	16	toxicity	toxicity	NOUN
gs-4060	595	17	profile	profile	NOUN
gs-4060	595	18	.	.	PUNCT
gs-4060	596	1	for	for	ADP
gs-4060	596	2	example	example	NOUN
gs-4060	596	3	,	,	PUNCT
gs-4060	596	4	the	the	DET
gs-4060	596	5	severe	severe	ADJ
gs-4060	596	6	diarrheal	diarrheal	NOUN
gs-4060	596	7	toxicity	toxicity	NOUN
gs-4060	596	8	associated	associate	VERB
gs-4060	596	9	with	with	ADP
gs-4060	596	10	the	the	DET
gs-4060	596	11	kinase	kinase	PROPN
gs-4060	596	12	inhibitor	inhibitor	NOUN
gs-4060	596	13	irinotecan	irinotecan	NOUN
gs-4060	596	14	is	be	AUX
gs-4060	596	15	driven	drive	VERB
gs-4060	596	16	by	by	ADP
gs-4060	596	17	bacterial	bacterial	ADJ
gs-4060	596	18	beta	beta	NOUN
gs-4060	596	19	-	-	PUNCT
gs-4060	596	20	glucuronidase	glucuronidase	NOUN
gs-4060	596	21	enzymes	enzyme	NOUN
gs-4060	596	22	in	in	ADP
gs-4060	596	23	the	the	DET
gs-4060	596	24	gut	gut	NOUN
gs-4060	596	25	that	that	PRON
gs-4060	596	26	reactivate	reactivate	VERB
gs-4060	596	27	the	the	DET
gs-4060	596	28	drug	drug	NOUN
gs-4060	596	29	's	's	PART
gs-4060	596	30	toxic	toxic	ADJ
gs-4060	596	31	metabolite	metabolite	NOUN
gs-4060	596	32	,	,	PUNCT
gs-4060	596	33	causing	cause	VERB
gs-4060	596	34	damage	damage	NOUN
gs-4060	596	35	to	to	ADP
gs-4060	596	36	the	the	DET
gs-4060	596	37	intestinal	intestinal	ADJ
gs-4060	596	38	epithelium	epithelium	NOUN
gs-4060	596	39	.	.	PUNCT
gs-4060	597	1	strategies	strategy	NOUN
gs-4060	597	2	to	to	PART
gs-4060	597	3	manipulate	manipulate	VERB
gs-4060	597	4	the	the	DET
gs-4060	597	5	microbiome	microbiome	NOUN
gs-4060	597	6	are	be	AUX
gs-4060	597	7	therefore	therefore	ADV
gs-4060	597	8	a	a	DET
gs-4060	597	9	major	major	ADJ
gs-4060	597	10	new	new	ADJ
gs-4060	597	11	therapeutic	therapeutic	ADJ
gs-4060	597	12	avenue	avenue	NOUN
gs-4060	597	13	.	.	PUNCT
gs-4060	598	1	these	these	PRON
gs-4060	598	2	include	include	VERB
gs-4060	598	3	fecal	fecal	ADJ
gs-4060	598	4	microbiota	microbiota	NOUN
gs-4060	598	5	transplantation	transplantation	NOUN
gs-4060	598	6	from	from	ADP
gs-4060	598	7	responding	respond	VERB
gs-4060	598	8	donors	donor	NOUN
gs-4060	598	9	to	to	ADP
gs-4060	598	10	non	non	NOUN
gs-4060	598	11	-	-	NOUN
gs-4060	598	12	responders	responder	NOUN
gs-4060	598	13	,	,	PUNCT
gs-4060	598	14	the	the	DET
gs-4060	598	15	use	use	NOUN
gs-4060	598	16	of	of	ADP
gs-4060	598	17	defined	define	VERB
gs-4060	598	18	bacterial	bacterial	ADJ
gs-4060	598	19	consortia	consortium	NOUN
gs-4060	598	20	(	(	PUNCT
gs-4060	598	21	probiotics	probiotic	NOUN
gs-4060	598	22	)	)	PUNCT
gs-4060	598	23	,	,	PUNCT
gs-4060	598	24	and	and	CCONJ
gs-4060	598	25	precision	precision	NOUN
gs-4060	598	26	prebiotics	prebiotic	NOUN
gs-4060	598	27	to	to	PART
gs-4060	598	28	nourish	nourish	VERB
gs-4060	598	29	beneficial	beneficial	ADJ
gs-4060	598	30	taxa	taxa	NOUN
gs-4060	598	31	,	,	PUNCT
gs-4060	598	32	and	and	CCONJ
gs-4060	598	33	the	the	DET
gs-4060	598	34	concomitant	concomitant	ADJ
gs-4060	598	35	use	use	NOUN
gs-4060	598	36	of	of	ADP
gs-4060	598	37	selective	selective	ADJ
gs-4060	598	38	microbial	microbial	ADJ
gs-4060	598	39	inhibitors	inhibitor	NOUN
gs-4060	598	40	to	to	PART
gs-4060	598	41	block	block	VERB
gs-4060	598	42	detrimental	detrimental	ADJ
gs-4060	598	43	bacterial	bacterial	ADJ
gs-4060	598	44	enzymes	enzyme	NOUN
gs-4060	598	45	without	without	ADP
gs-4060	598	46	causing	cause	VERB
gs-4060	598	47	broad	broad	ADJ
gs-4060	598	48	dysbiosis	dysbiosis	NOUN
gs-4060	598	49	.	.	PUNCT
gs-4060	599	1	this	this	DET
gs-4060	599	2	research	research	NOUN
gs-4060	599	3	is	be	AUX
gs-4060	599	4	forging	forge	VERB
gs-4060	599	5	a	a	DET
gs-4060	599	6	new	new	ADJ
gs-4060	599	7	field	field	NOUN
gs-4060	599	8	at	at	ADP
gs-4060	599	9	the	the	DET
gs-4060	599	10	intersection	intersection	NOUN
gs-4060	599	11	of	of	ADP
gs-4060	599	12	oncology	oncology	NOUN
gs-4060	599	13	and	and	CCONJ
gs-4060	599	14	microbiology	microbiology	NOUN
gs-4060	599	15	,	,	PUNCT
gs-4060	599	16	where	where	SCONJ
gs-4060	599	17	modulating	modulate	VERB
gs-4060	599	18	georgian	georgian	NOUN
gs-4060	599	19	scientists/	scientists/	NUM
gs-4060	599	20	.	.	PUNCT
gs-4060	600	1	7	7	NUM
gs-4060	600	2	n	n	PRON
gs-4060	600	3	3	3	NUM
gs-4060	600	4	,	,	PUNCT
gs-4060	600	5	2025	2025	NUM
gs-4060	600	6	597	597	NUM
gs-4060	601	1	the	the	DET
gs-4060	601	2	oncobiota	oncobiota	NOUN
gs-4060	601	3	may	may	AUX
gs-4060	601	4	become	become	VERB
gs-4060	601	5	a	a	DET
gs-4060	601	6	standard	standard	NOUN
gs-4060	601	7	adjuvant	adjuvant	ADJ
gs-4060	601	8	to	to	PART
gs-4060	601	9	enhance	enhance	VERB
gs-4060	601	10	the	the	DET
gs-4060	601	11	therapeutic	therapeutic	ADJ
gs-4060	601	12	index	index	NOUN
gs-4060	601	13	of	of	ADP
gs-4060	601	14	cancer	cancer	NOUN
gs-4060	601	15	treatments	treatment	NOUN
gs-4060	601	16	.	.	PUNCT
gs-4060	602	1	paradigm	paradigm	NOUN
gs-4060	602	2	shifts	shift	NOUN
gs-4060	602	3	in	in	ADP
gs-4060	602	4	clinical	clinical	ADJ
gs-4060	602	5	trial	trial	NOUN
gs-4060	602	6	design	design	NOUN
gs-4060	602	7	for	for	ADP
gs-4060	602	8	the	the	DET
gs-4060	602	9	modern	modern	ADJ
gs-4060	602	10	era	era	NOUN
gs-4060	602	11	the	the	DET
gs-4060	602	12	traditional	traditional	ADJ
gs-4060	602	13	phase	phase	NOUN
gs-4060	602	14	i	i	PROPN
gs-4060	602	15	-	-	PUNCT
gs-4060	602	16	ii	ii	PROPN
gs-4060	602	17	-	-	PUNCT
gs-4060	602	18	iii	iii	NOUN
gs-4060	602	19	sequential	sequential	ADJ
gs-4060	602	20	clinical	clinical	ADJ
gs-4060	602	21	trial	trial	NOUN
gs-4060	602	22	paradigm	paradigm	NOUN
gs-4060	602	23	,	,	PUNCT
gs-4060	602	24	designed	design	VERB
gs-4060	602	25	for	for	ADP
gs-4060	602	26	cytotoxic	cytotoxic	ADJ
gs-4060	602	27	chemotherapies	chemotherapy	NOUN
gs-4060	602	28	,	,	PUNCT
gs-4060	602	29	is	be	AUX
gs-4060	602	30	often	often	ADV
gs-4060	602	31	too	too	ADV
gs-4060	602	32	slow	slow	ADJ
gs-4060	602	33	,	,	PUNCT
gs-4060	602	34	inefficient	inefficient	ADJ
gs-4060	602	35	,	,	PUNCT
gs-4060	602	36	and	and	CCONJ
gs-4060	602	37	ill	ill	ADV
gs-4060	602	38	-	-	PUNCT
gs-4060	602	39	suited	suited	ADJ
gs-4060	602	40	for	for	ADP
gs-4060	602	41	evaluating	evaluate	VERB
gs-4060	602	42	the	the	DET
gs-4060	602	43	new	new	ADJ
gs-4060	602	44	generation	generation	NOUN
gs-4060	602	45	of	of	ADP
gs-4060	602	46	anticancer	anticancer	NOUN
gs-4060	602	47	drugs	drug	NOUN
gs-4060	602	48	.	.	PUNCT
gs-4060	603	1	the	the	DET
gs-4060	603	2	field	field	NOUN
gs-4060	603	3	is	be	AUX
gs-4060	603	4	rapidly	rapidly	ADV
gs-4060	603	5	adopting	adopt	VERB
gs-4060	603	6	innovative	innovative	ADJ
gs-4060	603	7	,	,	PUNCT
gs-4060	603	8	adaptive	adaptive	ADJ
gs-4060	603	9	trial	trial	NOUN
gs-4060	603	10	designs	design	NOUN
gs-4060	603	11	that	that	PRON
gs-4060	603	12	are	be	AUX
gs-4060	603	13	more	more	ADV
gs-4060	603	14	flexible	flexible	ADJ
gs-4060	603	15	,	,	PUNCT
gs-4060	603	16	efficient	efficient	ADJ
gs-4060	603	17	,	,	PUNCT
gs-4060	603	18	and	and	CCONJ
gs-4060	603	19	focused	focus	VERB
gs-4060	603	20	on	on	ADP
gs-4060	603	21	biomarker	biomarker	NOUN
gs-4060	603	22	-	-	PUNCT
gs-4060	603	23	driven	drive	VERB
gs-4060	603	24	patient	patient	NOUN
gs-4060	603	25	selection	selection	NOUN
gs-4060	603	26	.	.	PUNCT
gs-4060	604	1	the	the	DET
gs-4060	604	2	umbrella	umbrella	NOUN
gs-4060	604	3	and	and	CCONJ
gs-4060	604	4	basket	basket	NOUN
gs-4060	604	5	trial	trial	NOUN
gs-4060	604	6	designs	design	NOUN
gs-4060	604	7	represent	represent	VERB
gs-4060	604	8	a	a	DET
gs-4060	604	9	fundamental	fundamental	ADJ
gs-4060	604	10	shift	shift	NOUN
gs-4060	604	11	from	from	ADP
gs-4060	604	12	histology	histology	NOUN
gs-4060	604	13	-	-	PUNCT
gs-4060	604	14	based	base	VERB
gs-4060	604	15	to	to	ADP
gs-4060	604	16	biology	biology	NOUN
gs-4060	604	17	-	-	PUNCT
gs-4060	604	18	based	base	VERB
gs-4060	604	19	testing	testing	NOUN
gs-4060	604	20	.	.	PUNCT
gs-4060	605	1	basket	basket	NOUN
gs-4060	605	2	trials	trial	NOUN
gs-4060	605	3	evaluate	evaluate	VERB
gs-4060	605	4	the	the	DET
gs-4060	605	5	activity	activity	NOUN
gs-4060	605	6	of	of	ADP
gs-4060	605	7	a	a	DET
gs-4060	605	8	single	single	ADJ
gs-4060	605	9	targeted	target	VERB
gs-4060	605	10	therapy	therapy	NOUN
gs-4060	605	11	across	across	ADP
gs-4060	605	12	multiple	multiple	ADJ
gs-4060	605	13	different	different	ADJ
gs-4060	605	14	cancer	cancer	NOUN
gs-4060	605	15	types	type	NOUN
gs-4060	605	16	,	,	PUNCT
gs-4060	605	17	all	all	PRON
gs-4060	605	18	of	of	ADP
gs-4060	605	19	which	which	PRON
gs-4060	605	20	share	share	VERB
gs-4060	605	21	a	a	DET
gs-4060	605	22	common	common	ADJ
gs-4060	605	23	molecular	molecular	ADJ
gs-4060	605	24	alteration	alteration	NOUN
gs-4060	605	25	.	.	PUNCT
gs-4060	606	1	the	the	DET
gs-4060	606	2	landmark	landmark	PROPN
gs-4060	606	3	ncimatch	ncimatch	PROPN
gs-4060	606	4	and	and	CCONJ
gs-4060	606	5	asco	asco	ADJ
gs-4060	606	6	tapur	tapur	NOUN
gs-4060	606	7	trials	trial	NOUN
gs-4060	606	8	are	be	AUX
gs-4060	606	9	prime	prime	ADJ
gs-4060	606	10	examples	example	NOUN
gs-4060	606	11	,	,	PUNCT
gs-4060	606	12	screening	screen	VERB
gs-4060	606	13	thousands	thousand	NOUN
gs-4060	606	14	of	of	ADP
gs-4060	606	15	patients	patient	NOUN
gs-4060	606	16	to	to	PART
gs-4060	606	17	assign	assign	VERB
gs-4060	606	18	them	they	PRON
gs-4060	606	19	to	to	ADP
gs-4060	606	20	treatment	treatment	NOUN
gs-4060	606	21	arms	arm	NOUN
gs-4060	606	22	based	base	VERB
gs-4060	606	23	on	on	ADP
gs-4060	606	24	their	their	PRON
gs-4060	606	25	tumor	tumor	NOUN
gs-4060	606	26	's	's	PART
gs-4060	606	27	genetic	genetic	ADJ
gs-4060	606	28	profile	profile	NOUN
gs-4060	606	29	,	,	PUNCT
gs-4060	606	30	regardless	regardless	ADV
gs-4060	606	31	of	of	ADP
gs-4060	606	32	where	where	SCONJ
gs-4060	606	33	the	the	DET
gs-4060	606	34	cancer	cancer	NOUN
gs-4060	606	35	originated	originate	VERB
gs-4060	606	36	.	.	PUNCT
gs-4060	607	1	this	this	DET
gs-4060	607	2	design	design	NOUN
gs-4060	607	3	efficiently	efficiently	ADV
gs-4060	607	4	identifies	identify	VERB
gs-4060	607	5	signal	signal	NOUN
gs-4060	607	6	in	in	ADP
gs-4060	607	7	rare	rare	ADJ
gs-4060	607	8	tumor	tumor	NOUN
gs-4060	607	9	subtypes	subtype	NOUN
gs-4060	607	10	that	that	PRON
gs-4060	607	11	could	could	AUX
gs-4060	607	12	never	never	ADV
gs-4060	607	13	be	be	AUX
gs-4060	607	14	enrolled	enrol	VERB
gs-4060	607	15	in	in	ADP
gs-4060	607	16	a	a	DET
gs-4060	607	17	traditional	traditional	ADJ
gs-4060	607	18	histology	histology	NOUN
gs-4060	607	19	-	-	PUNCT
gs-4060	607	20	specific	specific	ADJ
gs-4060	607	21	trial	trial	NOUN
gs-4060	607	22	.	.	PUNCT
gs-4060	608	1	conversely	conversely	ADV
gs-4060	608	2	,	,	PUNCT
gs-4060	608	3	umbrella	umbrella	NOUN
gs-4060	608	4	trials	trial	NOUN
gs-4060	608	5	evaluate	evaluate	VERB
gs-4060	608	6	multiple	multiple	ADJ
gs-4060	608	7	different	different	ADJ
gs-4060	608	8	targeted	targeted	ADJ
gs-4060	608	9	therapies	therapy	NOUN
gs-4060	608	10	within	within	ADP
gs-4060	608	11	a	a	DET
gs-4060	608	12	single	single	ADJ
gs-4060	608	13	cancer	cancer	NOUN
gs-4060	608	14	type	type	NOUN
gs-4060	608	15	.	.	PUNCT
gs-4060	609	1	patients	patient	NOUN
gs-4060	609	2	with	with	ADP
gs-4060	609	3	a	a	DET
gs-4060	609	4	specific	specific	ADJ
gs-4060	609	5	cancer	cancer	NOUN
gs-4060	609	6	,	,	PUNCT
gs-4060	609	7	such	such	ADJ
gs-4060	609	8	as	as	ADP
gs-4060	609	9	nonsmall	nonsmall	NOUN
gs-4060	609	10	cell	cell	NOUN
gs-4060	609	11	lung	lung	NOUN
gs-4060	609	12	cancer	cancer	NOUN
gs-4060	609	13	,	,	PUNCT
gs-4060	609	14	are	be	AUX
gs-4060	609	15	screened	screen	VERB
gs-4060	609	16	for	for	ADP
gs-4060	609	17	a	a	DET
gs-4060	609	18	panel	panel	NOUN
gs-4060	609	19	of	of	ADP
gs-4060	609	20	biomarkers	biomarker	NOUN
gs-4060	609	21	and	and	CCONJ
gs-4060	609	22	then	then	ADV
gs-4060	609	23	assigned	assign	VERB
gs-4060	609	24	to	to	ADP
gs-4060	609	25	different	different	ADJ
gs-4060	609	26	substudies	substudie	NOUN
gs-4060	609	27	within	within	ADP
gs-4060	609	28	the	the	DET
gs-4060	609	29	master	master	NOUN
gs-4060	609	30	protocol	protocol	NOUN
gs-4060	609	31	based	base	VERB
gs-4060	609	32	on	on	ADP
gs-4060	609	33	their	their	PRON
gs-4060	609	34	individual	individual	ADJ
gs-4060	609	35	biomarker	biomarker	NOUN
gs-4060	609	36	result	result	NOUN
gs-4060	609	37	.	.	PUNCT
gs-4060	610	1	this	this	PRON
gs-4060	610	2	allows	allow	VERB
gs-4060	610	3	for	for	ADP
gs-4060	610	4	the	the	DET
gs-4060	610	5	simultaneous	simultaneous	ADJ
gs-4060	610	6	and	and	CCONJ
gs-4060	610	7	efficient	efficient	ADJ
gs-4060	610	8	comparison	comparison	NOUN
gs-4060	610	9	of	of	ADP
gs-4060	610	10	several	several	ADJ
gs-4060	610	11	biomarker	biomarker	NOUN
gs-4060	610	12	-	-	PUNCT
gs-4060	610	13	matched	match	VERB
gs-4060	610	14	therapies	therapy	NOUN
gs-4060	610	15	against	against	ADP
gs-4060	610	16	a	a	DET
gs-4060	610	17	common	common	ADJ
gs-4060	610	18	control	control	NOUN
gs-4060	610	19	arm	arm	NOUN
gs-4060	610	20	.	.	PUNCT
gs-4060	611	1	adaptive	adaptive	ADJ
gs-4060	611	2	trial	trial	NOUN
gs-4060	611	3	designs	design	NOUN
gs-4060	611	4	incorporate	incorporate	VERB
gs-4060	611	5	pre	pre	ADJ
gs-4060	611	6	-	-	ADJ
gs-4060	611	7	specified	specified	ADJ
gs-4060	611	8	modifications	modification	NOUN
gs-4060	611	9	to	to	ADP
gs-4060	611	10	the	the	DET
gs-4060	611	11	trial	trial	NOUN
gs-4060	611	12	’s	’s	PART
gs-4060	611	13	design	design	NOUN
gs-4060	611	14	based	base	VERB
gs-4060	611	15	on	on	ADP
gs-4060	611	16	interim	interim	ADJ
gs-4060	611	17	analysis	analysis	NOUN
gs-4060	611	18	of	of	ADP
gs-4060	611	19	accumulating	accumulate	VERB
gs-4060	611	20	data	datum	NOUN
gs-4060	611	21	.	.	PUNCT
gs-4060	612	1	unlike	unlike	ADP
gs-4060	612	2	traditional	traditional	ADJ
gs-4060	612	3	trials	trial	NOUN
gs-4060	612	4	,	,	PUNCT
gs-4060	612	5	which	which	PRON
gs-4060	612	6	are	be	AUX
gs-4060	612	7	static	static	ADJ
gs-4060	612	8	,	,	PUNCT
gs-4060	612	9	adaptive	adaptive	ADJ
gs-4060	612	10	designs	design	NOUN
gs-4060	612	11	can	can	AUX
gs-4060	612	12	allow	allow	VERB
gs-4060	612	13	for	for	ADP
gs-4060	612	14	:	:	PUNCT
gs-4060	612	15	dropping	drop	VERB
gs-4060	612	16	underperforming	underperform	VERB
gs-4060	612	17	treatment	treatment	NOUN
gs-4060	612	18	arms	arm	NOUN
gs-4060	612	19	;	;	PUNCT
gs-4060	612	20	adjusting	adjust	VERB
gs-4060	612	21	randomization	randomization	NOUN
gs-4060	612	22	ratios	ratio	NOUN
gs-4060	612	23	to	to	PART
gs-4060	612	24	favor	favor	VERB
gs-4060	612	25	more	more	ADV
gs-4060	612	26	effective	effective	ADJ
gs-4060	612	27	therapies	therapy	NOUN
gs-4060	612	28	;	;	PUNCT
gs-4060	612	29	modifying	modify	VERB
gs-4060	612	30	sample	sample	NOUN
gs-4060	612	31	size	size	NOUN
gs-4060	612	32	based	base	VERB
gs-4060	612	33	on	on	ADP
gs-4060	612	34	interim	interim	ADJ
gs-4060	612	35	effect	effect	NOUN
gs-4060	612	36	size	size	NOUN
gs-4060	612	37	;	;	PUNCT
gs-4060	612	38	and	and	CCONJ
gs-4060	612	39	seamlessly	seamlessly	ADV
gs-4060	612	40	expanding	expand	VERB
gs-4060	612	41	a	a	DET
gs-4060	612	42	phase	phase	NOUN
gs-4060	612	43	i	i	PRON
gs-4060	612	44	dose	dose	NOUN
gs-4060	612	45	-	-	PUNCT
gs-4060	612	46	escalation	escalation	NOUN
gs-4060	612	47	cohort	cohort	NOUN
gs-4060	612	48	into	into	ADP
gs-4060	612	49	a	a	DET
gs-4060	612	50	biomarker	biomarker	NOUN
gs-4060	612	51	-	-	PUNCT
gs-4060	612	52	selected	select	VERB
gs-4060	612	53	expansion	expansion	NOUN
gs-4060	612	54	cohort	cohort	NOUN
gs-4060	612	55	.	.	PUNCT
gs-4060	613	1	platforms	platform	NOUN
gs-4060	613	2	like	like	ADP
gs-4060	613	3	the	the	DET
gs-4060	613	4	i	i	NOUN
gs-4060	613	5	-	-	NOUN
gs-4060	613	6	spy	spy	NOUN
gs-4060	613	7	2	2	NUM
gs-4060	613	8	trial	trial	NOUN
gs-4060	613	9	for	for	ADP
gs-4060	613	10	neoadjuvant	neoadjuvant	ADJ
gs-4060	613	11	breast	breast	NOUN
gs-4060	613	12	cancer	cancer	NOUN
gs-4060	613	13	treatment	treatment	NOUN
gs-4060	613	14	use	use	VERB
gs-4060	613	15	adaptive	adaptive	ADJ
gs-4060	613	16	randomization	randomization	NOUN
gs-4060	613	17	to	to	PART
gs-4060	613	18	assign	assign	VERB
gs-4060	613	19	patients	patient	NOUN
gs-4060	613	20	to	to	ADP
gs-4060	613	21	one	one	NUM
gs-4060	613	22	of	of	ADP
gs-4060	613	23	several	several	ADJ
gs-4060	613	24	experimental	experimental	ADJ
gs-4060	613	25	regimens	regimen	NOUN
gs-4060	613	26	added	add	VERB
gs-4060	613	27	to	to	ADP
gs-4060	613	28	standard	standard	ADJ
gs-4060	613	29	chemotherapy	chemotherapy	NOUN
gs-4060	613	30	,	,	PUNCT
gs-4060	613	31	with	with	ADP
gs-4060	613	32	the	the	DET
gs-4060	613	33	goal	goal	NOUN
gs-4060	613	34	of	of	ADP
gs-4060	613	35	rapidly	rapidly	ADV
gs-4060	613	36	identifying	identify	VERB
gs-4060	613	37	which	which	DET
gs-4060	613	38	therapies	therapy	NOUN
gs-4060	613	39	are	be	AUX
gs-4060	613	40	most	most	ADV
gs-4060	613	41	promising	promising	ADJ
gs-4060	613	42	for	for	ADP
gs-4060	613	43	specific	specific	ADJ
gs-4060	613	44	biomarker	biomarker	NOUN
gs-4060	613	45	signatures	signature	NOUN
gs-4060	613	46	.	.	PUNCT
gs-4060	614	1	these	these	DET
gs-4060	614	2	designs	design	NOUN
gs-4060	614	3	accelerate	accelerate	VERB
gs-4060	614	4	the	the	DET
gs-4060	614	5	drug	drug	NOUN
gs-4060	614	6	development	development	NOUN
gs-4060	614	7	process	process	NOUN
gs-4060	614	8	by	by	ADP
gs-4060	614	9	making	make	VERB
gs-4060	614	10	real	real	ADJ
gs-4060	614	11	-	-	PUNCT
gs-4060	614	12	time	time	NOUN
gs-4060	614	13	decisions	decision	NOUN
gs-4060	614	14	based	base	VERB
gs-4060	614	15	on	on	ADP
gs-4060	614	16	efficacy	efficacy	NOUN
gs-4060	614	17	,	,	PUNCT
gs-4060	614	18	ultimately	ultimately	ADV
gs-4060	614	19	getting	get	VERB
gs-4060	614	20	effective	effective	ADJ
gs-4060	614	21	drugs	drug	NOUN
gs-4060	614	22	to	to	ADP
gs-4060	614	23	patients	patient	NOUN
gs-4060	614	24	faster	fast	ADV
gs-4060	614	25	and	and	CCONJ
gs-4060	614	26	more	more	ADV
gs-4060	614	27	efficiently	efficiently	ADV
gs-4060	614	28	discontinuing	discontinue	VERB
gs-4060	614	29	the	the	DET
gs-4060	614	30	development	development	NOUN
gs-4060	614	31	of	of	ADP
gs-4060	614	32	ineffective	ineffective	ADJ
gs-4060	614	33	ones	one	NOUN
gs-4060	614	34	.	.	PUNCT
gs-4060	615	1	furthermore	furthermore	ADV
gs-4060	615	2	,	,	PUNCT
gs-4060	615	3	the	the	DET
gs-4060	615	4	endpoints	endpoint	NOUN
gs-4060	615	5	themselves	themselves	PRON
gs-4060	615	6	are	be	AUX
gs-4060	615	7	evolving	evolve	VERB
gs-4060	615	8	.	.	PUNCT
gs-4060	616	1	for	for	ADP
gs-4060	616	2	targeted	target	VERB
gs-4060	616	3	therapies	therapy	NOUN
gs-4060	616	4	that	that	PRON
gs-4060	616	5	often	often	ADV
gs-4060	616	6	induce	induce	VERB
gs-4060	616	7	stable	stable	ADJ
gs-4060	616	8	disease	disease	NOUN
gs-4060	616	9	rather	rather	ADV
gs-4060	616	10	than	than	ADP
gs-4060	616	11	tumor	tumor	NOUN
gs-4060	616	12	shrinkage	shrinkage	NOUN
gs-4060	616	13	,	,	PUNCT
gs-4060	616	14	and	and	CCONJ
gs-4060	616	15	for	for	ADP
gs-4060	616	16	immunotherapies	immunotherapy	NOUN
gs-4060	616	17	that	that	PRON
gs-4060	616	18	can	can	AUX
gs-4060	616	19	manifest	manifest	VERB
gs-4060	616	20	pseudoprogression	pseudoprogression	NOUN
gs-4060	616	21	,	,	PUNCT
gs-4060	616	22	overall	overall	ADJ
gs-4060	616	23	survival	survival	NOUN
gs-4060	616	24	remains	remain	VERB
gs-4060	616	25	the	the	DET
gs-4060	616	26	gold	gold	ADJ
gs-4060	616	27	standard	standard	NOUN
gs-4060	616	28	but	but	CCONJ
gs-4060	616	29	requires	require	VERB
gs-4060	616	30	large	large	ADJ
gs-4060	616	31	sample	sample	NOUN
gs-4060	616	32	sizes	size	NOUN
gs-4060	616	33	and	and	CCONJ
gs-4060	616	34	long	long	ADJ
gs-4060	616	35	follow	follow	NOUN
gs-4060	616	36	-	-	PUNCT
gs-4060	616	37	up	up	NOUN
gs-4060	616	38	.	.	PUNCT
gs-4060	617	1	there	there	PRON
gs-4060	617	2	is	be	VERB
gs-4060	617	3	a	a	DET
gs-4060	617	4	growing	grow	VERB
gs-4060	617	5	emphasis	emphasis	NOUN
gs-4060	617	6	on	on	ADP
gs-4060	617	7	validated	validate	VERB
gs-4060	617	8	surrogate	surrogate	ADJ
gs-4060	617	9	endpoints	endpoint	NOUN
gs-4060	617	10	like	like	ADP
gs-4060	617	11	progression	progression	NOUN
gs-4060	617	12	-	-	PUNCT
gs-4060	617	13	free	free	ADJ
gs-4060	617	14	survival	survival	NOUN
gs-4060	617	15	and	and	CCONJ
gs-4060	617	16	duration	duration	NOUN
gs-4060	617	17	of	of	ADP
gs-4060	617	18	response	response	NOUN
gs-4060	617	19	.	.	PUNCT
gs-4060	618	1	in	in	ADP
gs-4060	618	2	the	the	DET
gs-4060	618	3	neoadjuvant	neoadjuvant	ADJ
gs-4060	618	4	and	and	CCONJ
gs-4060	618	5	adjuvant	adjuvant	ADJ
gs-4060	618	6	settings	setting	NOUN
gs-4060	618	7	,	,	PUNCT
gs-4060	618	8	pathological	pathological	ADJ
gs-4060	618	9	complete	complete	ADJ
gs-4060	618	10	response	response	NOUN
gs-4060	618	11	and	and	CCONJ
gs-4060	618	12	event	event	NOUN
gs-4060	618	13	-	-	PUNCT
gs-4060	618	14	free	free	ADJ
gs-4060	618	15	survival	survival	NOUN
gs-4060	618	16	are	be	AUX
gs-4060	618	17	gaining	gain	VERB
gs-4060	618	18	prominence	prominence	NOUN
gs-4060	618	19	.	.	PUNCT
gs-4060	619	1	for	for	ADP
gs-4060	619	2	cell	cell	NOUN
gs-4060	619	3	therapies	therapy	NOUN
gs-4060	619	4	,	,	PUNCT
gs-4060	619	5	novel	novel	ADJ
gs-4060	619	6	endpoints	endpoint	NOUN
gs-4060	619	7	such	such	ADJ
gs-4060	619	8	as	as	ADP
gs-4060	619	9	duration	duration	NOUN
gs-4060	619	10	of	of	ADP
gs-4060	619	11	complete	complete	ADJ
gs-4060	619	12	response	response	NOUN
gs-4060	619	13	are	be	AUX
gs-4060	619	14	critical	critical	ADJ
gs-4060	619	15	.	.	PUNCT
gs-4060	620	1	the	the	DET
gs-4060	620	2	validation	validation	NOUN
gs-4060	620	3	of	of	ADP
gs-4060	620	4	these	these	DET
gs-4060	620	5	endpoints	endpoint	NOUN
gs-4060	620	6	,	,	PUNCT
gs-4060	620	7	coupled	couple	VERB
gs-4060	620	8	with	with	ADP
gs-4060	620	9	the	the	DET
gs-4060	620	10	use	use	NOUN
gs-4060	620	11	of	of	ADP
gs-4060	620	12	real	real	ADJ
gs-4060	620	13	-	-	PUNCT
gs-4060	620	14	world	world	NOUN
gs-4060	620	15	evidence	evidence	NOUN
gs-4060	620	16	to	to	PART
gs-4060	620	17	supplement	supplement	VERB
gs-4060	620	18	clinical	clinical	ADJ
gs-4060	620	19	trial	trial	NOUN
gs-4060	620	20	data	datum	NOUN
gs-4060	620	21	,	,	PUNCT
gs-4060	620	22	is	be	AUX
gs-4060	620	23	creating	create	VERB
gs-4060	620	24	a	a	DET
gs-4060	620	25	more	more	ADV
gs-4060	620	26	nuanced	nuanced	ADJ
gs-4060	620	27	and	and	CCONJ
gs-4060	620	28	rapid	rapid	ADJ
gs-4060	620	29	framework	framework	NOUN
gs-4060	620	30	for	for	ADP
gs-4060	620	31	evaluating	evaluate	VERB
gs-4060	620	32	the	the	DET
gs-4060	620	33	clinical	clinical	ADJ
gs-4060	620	34	benefit	benefit	NOUN
gs-4060	620	35	of	of	ADP
gs-4060	620	36	new	new	ADJ
gs-4060	620	37	anticancer	anticancer	NOUN
gs-4060	620	38	agents	agent	NOUN
gs-4060	620	39	.	.	PUNCT
gs-4060	621	1	this	this	DET
gs-4060	621	2	continued	continue	VERB
gs-4060	621	3	exploration	exploration	NOUN
gs-4060	621	4	into	into	ADP
gs-4060	621	5	the	the	DET
gs-4060	621	6	dynamics	dynamic	NOUN
gs-4060	621	7	of	of	ADP
gs-4060	621	8	resistance	resistance	NOUN
gs-4060	621	9	,	,	PUNCT
gs-4060	621	10	the	the	DET
gs-4060	621	11	influence	influence	NOUN
gs-4060	621	12	of	of	ADP
gs-4060	621	13	the	the	DET
gs-4060	621	14	microbiome	microbiome	NOUN
gs-4060	621	15	,	,	PUNCT
gs-4060	621	16	and	and	CCONJ
gs-4060	621	17	the	the	DET
gs-4060	621	18	evolution	evolution	NOUN
gs-4060	621	19	of	of	ADP
gs-4060	621	20	clinical	clinical	ADJ
gs-4060	621	21	research	research	NOUN
gs-4060	621	22	methodologies	methodology	NOUN
gs-4060	621	23	highlights	highlight	NOUN
gs-4060	621	24	that	that	SCONJ
gs-4060	621	25	the	the	DET
gs-4060	621	26	future	future	NOUN
gs-4060	621	27	of	of	ADP
gs-4060	621	28	oncology	oncology	NOUN
gs-4060	621	29	is	be	AUX
gs-4060	621	30	not	not	PART
gs-4060	621	31	merely	merely	ADV
gs-4060	621	32	about	about	ADP
gs-4060	621	33	developing	develop	VERB
gs-4060	621	34	new	new	ADJ
gs-4060	621	35	drugs	drug	NOUN
gs-4060	621	36	,	,	PUNCT
gs-4060	621	37	but	but	CCONJ
gs-4060	621	38	about	about	ADP
gs-4060	621	39	developing	develop	VERB
gs-4060	621	40	a	a	DET
gs-4060	621	41	deeper	deep	ADJ
gs-4060	621	42	,	,	PUNCT
gs-4060	621	43	more	more	ADV
gs-4060	621	44	holistic	holistic	ADJ
gs-4060	621	45	georgian	georgian	NOUN
gs-4060	621	46	scientists/	scientists/	NUM
gs-4060	621	47	.	.	PUNCT
gs-4060	622	1	7	7	NUM
gs-4060	622	2	n	n	PRON
gs-4060	622	3	3	3	NUM
gs-4060	622	4	,	,	PUNCT
gs-4060	622	5	2025	2025	NUM
gs-4060	622	6	598	598	NUM
gs-4060	622	7	understanding	understanding	NOUN
gs-4060	622	8	of	of	ADP
gs-4060	622	9	the	the	DET
gs-4060	622	10	disease	disease	NOUN
gs-4060	622	11	and	and	CCONJ
gs-4060	622	12	creating	create	VERB
gs-4060	622	13	a	a	DET
gs-4060	622	14	more	more	ADV
gs-4060	622	15	agile	agile	ADJ
gs-4060	622	16	and	and	CCONJ
gs-4060	622	17	intelligent	intelligent	ADJ
gs-4060	622	18	system	system	NOUN
gs-4060	622	19	to	to	PART
gs-4060	622	20	evaluate	evaluate	VERB
gs-4060	622	21	and	and	CCONJ
gs-4060	622	22	deliver	deliver	VERB
gs-4060	622	23	care	care	NOUN
gs-4060	622	24	.	.	PUNCT
gs-4060	623	1	the	the	DET
gs-4060	623	2	integration	integration	NOUN
gs-4060	623	3	of	of	ADP
gs-4060	623	4	these	these	DET
gs-4060	623	5	complex	complex	ADJ
gs-4060	623	6	,	,	PUNCT
gs-4060	623	7	multidisciplinary	multidisciplinary	ADJ
gs-4060	623	8	insights	insight	NOUN
gs-4060	623	9	is	be	AUX
gs-4060	623	10	paving	pave	VERB
gs-4060	623	11	the	the	DET
gs-4060	623	12	way	way	NOUN
gs-4060	623	13	for	for	ADP
gs-4060	623	14	the	the	DET
gs-4060	623	15	next	next	ADJ
gs-4060	623	16	revolution	revolution	NOUN
gs-4060	623	17	in	in	ADP
gs-4060	623	18	cancer	cancer	NOUN
gs-4060	623	19	treatment	treatment	NOUN
gs-4060	623	20	.	.	PUNCT
gs-4060	624	1	the	the	DET
gs-4060	624	2	atomic	atomic	ADJ
gs-4060	624	3	level	level	NOUN
gs-4060	624	4	:	:	PUNCT
gs-4060	624	5	structural	structural	ADJ
gs-4060	624	6	biology	biology	NOUN
gs-4060	624	7	and	and	CCONJ
gs-4060	624	8	rational	rational	ADJ
gs-4060	624	9	drug	drug	NOUN
gs-4060	624	10	design	design	VERB
gs-4060	624	11	the	the	DET
gs-4060	624	12	efficacy	efficacy	NOUN
gs-4060	624	13	and	and	CCONJ
gs-4060	624	14	specificity	specificity	NOUN
gs-4060	624	15	of	of	ADP
gs-4060	624	16	new	new	ADJ
gs-4060	624	17	anticancer	anticancer	NOUN
gs-4060	624	18	drugs	drug	NOUN
gs-4060	624	19	are	be	AUX
gs-4060	624	20	not	not	PART
gs-4060	624	21	accidental	accidental	ADJ
gs-4060	624	22	but	but	CCONJ
gs-4060	624	23	are	be	AUX
gs-4060	624	24	born	bear	VERB
gs-4060	624	25	from	from	ADP
gs-4060	624	26	a	a	DET
gs-4060	624	27	precise	precise	ADJ
gs-4060	624	28	understanding	understanding	NOUN
gs-4060	624	29	of	of	ADP
gs-4060	624	30	interactions	interaction	NOUN
gs-4060	624	31	at	at	ADP
gs-4060	624	32	the	the	DET
gs-4060	624	33	atomic	atomic	ADJ
gs-4060	624	34	level	level	NOUN
gs-4060	624	35	.	.	PUNCT
gs-4060	625	1	the	the	DET
gs-4060	625	2	field	field	NOUN
gs-4060	625	3	of	of	ADP
gs-4060	625	4	structural	structural	ADJ
gs-4060	625	5	biology	biology	NOUN
gs-4060	625	6	,	,	PUNCT
gs-4060	625	7	utilizing	utilize	VERB
gs-4060	625	8	techniques	technique	NOUN
gs-4060	625	9	like	like	ADP
gs-4060	625	10	x	x	NOUN
gs-4060	625	11	-	-	NOUN
gs-4060	625	12	ray	ray	NOUN
gs-4060	625	13	crystallography	crystallography	NOUN
gs-4060	625	14	and	and	CCONJ
gs-4060	625	15	cryo	cryo	NOUN
gs-4060	625	16	-	-	PUNCT
gs-4060	625	17	electron	electron	NOUN
gs-4060	625	18	microscopy	microscopy	NOUN
gs-4060	625	19	,	,	PUNCT
gs-4060	625	20	has	have	AUX
gs-4060	625	21	provided	provide	VERB
gs-4060	625	22	high	high	ADJ
gs-4060	625	23	-	-	PUNCT
gs-4060	625	24	resolution	resolution	NOUN
gs-4060	625	25	blueprints	blueprint	NOUN
gs-4060	625	26	of	of	ADP
gs-4060	625	27	target	target	NOUN
gs-4060	625	28	proteins	protein	NOUN
gs-4060	625	29	,	,	PUNCT
gs-4060	625	30	revealing	reveal	VERB
gs-4060	625	31	the	the	DET
gs-4060	625	32	intricate	intricate	ADJ
gs-4060	625	33	three	three	NUM
gs-4060	625	34	-	-	PUNCT
gs-4060	625	35	dimensional	dimensional	ADJ
gs-4060	625	36	architecture	architecture	NOUN
gs-4060	625	37	of	of	ADP
gs-4060	625	38	active	active	ADJ
gs-4060	625	39	sites	site	NOUN
gs-4060	625	40	,	,	PUNCT
gs-4060	625	41	allosteric	allosteric	ADJ
gs-4060	625	42	pockets	pocket	NOUN
gs-4060	625	43	,	,	PUNCT
gs-4060	625	44	and	and	CCONJ
gs-4060	625	45	protein	protein	NOUN
gs-4060	625	46	-	-	PUNCT
gs-4060	625	47	protein	protein	NOUN
gs-4060	625	48	interfaces	interface	NOUN
gs-4060	625	49	.	.	PUNCT
gs-4060	626	1	this	this	DET
gs-4060	626	2	atomic	atomic	ADJ
gs-4060	626	3	-	-	PUNCT
gs-4060	626	4	level	level	NOUN
gs-4060	626	5	insight	insight	NOUN
gs-4060	626	6	is	be	AUX
gs-4060	626	7	the	the	DET
gs-4060	626	8	foundation	foundation	NOUN
gs-4060	626	9	of	of	ADP
gs-4060	626	10	rational	rational	ADJ
gs-4060	626	11	drug	drug	NOUN
gs-4060	626	12	design	design	NOUN
gs-4060	626	13	,	,	PUNCT
gs-4060	626	14	allowing	allow	VERB
gs-4060	626	15	medicinal	medicinal	ADJ
gs-4060	626	16	chemists	chemist	NOUN
gs-4060	626	17	to	to	PART
gs-4060	626	18	computationally	computationally	ADV
gs-4060	626	19	model	model	VERB
gs-4060	626	20	and	and	CCONJ
gs-4060	626	21	craft	craft	VERB
gs-4060	626	22	small	small	ADJ
gs-4060	626	23	molecules	molecule	NOUN
gs-4060	626	24	that	that	PRON
gs-4060	626	25	fit	fit	VERB
gs-4060	626	26	into	into	ADP
gs-4060	626	27	these	these	DET
gs-4060	626	28	targets	target	NOUN
gs-4060	626	29	with	with	ADP
gs-4060	626	30	the	the	DET
gs-4060	626	31	precision	precision	NOUN
gs-4060	626	32	of	of	ADP
gs-4060	626	33	a	a	DET
gs-4060	626	34	key	key	NOUN
gs-4060	626	35	in	in	ADP
gs-4060	626	36	a	a	DET
gs-4060	626	37	lock	lock	NOUN
gs-4060	626	38	.	.	PUNCT
gs-4060	627	1	the	the	DET
gs-4060	627	2	evolution	evolution	NOUN
gs-4060	627	3	of	of	ADP
gs-4060	627	4	kinase	kinase	PROPN
gs-4060	627	5	inhibitor	inhibitor	PROPN
gs-4060	627	6	development	development	NOUN
gs-4060	627	7	exemplifies	exemplify	VERB
gs-4060	627	8	this	this	DET
gs-4060	627	9	principle	principle	NOUN
gs-4060	627	10	.	.	PUNCT
gs-4060	628	1	first	first	ADJ
gs-4060	628	2	-	-	PUNCT
gs-4060	628	3	generation	generation	NOUN
gs-4060	628	4	inhibitors	inhibitor	NOUN
gs-4060	628	5	targeted	target	VERB
gs-4060	628	6	the	the	DET
gs-4060	628	7	highly	highly	ADV
gs-4060	628	8	conserved	conserve	VERB
gs-4060	628	9	atp	atp	NOUN
gs-4060	628	10	-	-	PUNCT
gs-4060	628	11	binding	bind	VERB
gs-4060	628	12	site	site	NOUN
gs-4060	628	13	,	,	PUNCT
gs-4060	628	14	which	which	PRON
gs-4060	628	15	often	often	ADV
gs-4060	628	16	led	lead	VERB
gs-4060	628	17	to	to	ADP
gs-4060	628	18	off	off	ADP
gs-4060	628	19	-	-	PUNCT
gs-4060	628	20	target	target	NOUN
gs-4060	628	21	effects	effect	NOUN
gs-4060	628	22	due	due	ADJ
gs-4060	628	23	to	to	ADP
gs-4060	628	24	similarities	similarity	NOUN
gs-4060	628	25	across	across	ADP
gs-4060	628	26	the	the	DET
gs-4060	628	27	kinome	kinome	NOUN
gs-4060	628	28	.	.	PUNCT
gs-4060	629	1	second	second	ADJ
gs-4060	629	2	and	and	CCONJ
gs-4060	629	3	third	third	ADJ
gs-4060	629	4	-	-	PUNCT
gs-4060	629	5	generation	generation	NOUN
gs-4060	629	6	drugs	drug	NOUN
gs-4060	629	7	were	be	AUX
gs-4060	629	8	designed	design	VERB
gs-4060	629	9	to	to	PART
gs-4060	629	10	exploit	exploit	VERB
gs-4060	629	11	unique	unique	ADJ
gs-4060	629	12	structural	structural	ADJ
gs-4060	629	13	features	feature	NOUN
gs-4060	629	14	within	within	ADP
gs-4060	629	15	or	or	CCONJ
gs-4060	629	16	adjacent	adjacent	ADJ
gs-4060	629	17	to	to	ADP
gs-4060	629	18	the	the	DET
gs-4060	629	19	atp	atp	NOUN
gs-4060	629	20	pocket	pocket	NOUN
gs-4060	629	21	.	.	PUNCT
gs-4060	630	1	for	for	ADP
gs-4060	630	2	instance	instance	NOUN
gs-4060	630	3	,	,	PUNCT
gs-4060	630	4	the	the	DET
gs-4060	630	5	"	"	PUNCT
gs-4060	630	6	dfg	dfg	NOUN
gs-4060	630	7	-	-	PUNCT
gs-4060	630	8	out	out	NOUN
gs-4060	630	9	"	"	PUNCT
gs-4060	630	10	or	or	CCONJ
gs-4060	630	11	"	"	PUNCT
gs-4060	630	12	chelix	chelix	ADJ
gs-4060	630	13	-	-	PUNCT
gs-4060	630	14	in	in	ADP
gs-4060	630	15	"	"	PUNCT
gs-4060	630	16	conformations	conformation	NOUN
gs-4060	630	17	of	of	ADP
gs-4060	630	18	certain	certain	ADJ
gs-4060	630	19	kinases	kinase	NOUN
gs-4060	630	20	create	create	VERB
gs-4060	630	21	distinct	distinct	ADJ
gs-4060	630	22	hydrophobic	hydrophobic	NOUN
gs-4060	630	23	pockets	pocket	NOUN
gs-4060	630	24	that	that	PRON
gs-4060	630	25	can	can	AUX
gs-4060	630	26	be	be	AUX
gs-4060	630	27	targeted	target	VERB
gs-4060	630	28	to	to	PART
gs-4060	630	29	achieve	achieve	VERB
gs-4060	630	30	greater	great	ADJ
gs-4060	630	31	selectivity	selectivity	NOUN
gs-4060	630	32	.	.	PUNCT
gs-4060	631	1	the	the	DET
gs-4060	631	2	development	development	NOUN
gs-4060	631	3	of	of	ADP
gs-4060	631	4	allosteric	allosteric	ADJ
gs-4060	631	5	inhibitors	inhibitor	NOUN
gs-4060	631	6	represents	represent	VERB
gs-4060	631	7	an	an	DET
gs-4060	631	8	even	even	ADV
gs-4060	631	9	more	more	ADV
gs-4060	631	10	sophisticated	sophisticated	ADJ
gs-4060	631	11	approach	approach	NOUN
gs-4060	631	12	.	.	PUNCT
gs-4060	632	1	these	these	DET
gs-4060	632	2	compounds	compound	NOUN
gs-4060	632	3	bind	bind	VERB
gs-4060	632	4	to	to	ADP
gs-4060	632	5	a	a	DET
gs-4060	632	6	site	site	NOUN
gs-4060	632	7	remote	remote	NOUN
gs-4060	632	8	from	from	ADP
gs-4060	632	9	the	the	DET
gs-4060	632	10	active	active	ADJ
gs-4060	632	11	site	site	NOUN
gs-4060	632	12	,	,	PUNCT
gs-4060	632	13	inducing	induce	VERB
gs-4060	632	14	a	a	DET
gs-4060	632	15	conformational	conformational	ADJ
gs-4060	632	16	change	change	NOUN
gs-4060	632	17	that	that	PRON
gs-4060	632	18	indirectly	indirectly	ADV
gs-4060	632	19	inhibits	inhibit	VERB
gs-4060	632	20	enzyme	enzyme	NOUN
gs-4060	632	21	activity	activity	NOUN
gs-4060	632	22	.	.	PUNCT
gs-4060	633	1	this	this	DET
gs-4060	633	2	mode	mode	NOUN
gs-4060	633	3	of	of	ADP
gs-4060	633	4	action	action	NOUN
gs-4060	633	5	often	often	ADV
gs-4060	633	6	confers	confer	VERB
gs-4060	633	7	exquisite	exquisite	ADJ
gs-4060	633	8	selectivity	selectivity	NOUN
gs-4060	633	9	,	,	PUNCT
gs-4060	633	10	as	as	SCONJ
gs-4060	633	11	allosteric	allosteric	ADJ
gs-4060	633	12	sites	site	NOUN
gs-4060	633	13	are	be	AUX
gs-4060	633	14	typically	typically	ADV
gs-4060	633	15	less	less	ADV
gs-4060	633	16	conserved	conserved	ADJ
gs-4060	633	17	than	than	ADP
gs-4060	633	18	the	the	DET
gs-4060	633	19	atp	atp	NOUN
gs-4060	633	20	-	-	PUNCT
gs-4060	633	21	binding	bind	VERB
gs-4060	633	22	site	site	NOUN
gs-4060	633	23	across	across	ADP
gs-4060	633	24	protein	protein	NOUN
gs-4060	633	25	families	family	NOUN
gs-4060	633	26	.	.	PUNCT
gs-4060	634	1	furthermore	furthermore	ADV
gs-4060	634	2	,	,	PUNCT
gs-4060	634	3	understanding	understand	VERB
gs-4060	634	4	the	the	DET
gs-4060	634	5	precise	precise	ADJ
gs-4060	634	6	molecular	molecular	ADJ
gs-4060	634	7	contacts	contact	NOUN
gs-4060	634	8	that	that	PRON
gs-4060	634	9	drive	drive	VERB
gs-4060	634	10	drug	drug	NOUN
gs-4060	634	11	binding	binding	NOUN
gs-4060	634	12	allows	allow	VERB
gs-4060	634	13	for	for	ADP
gs-4060	634	14	the	the	DET
gs-4060	634	15	intelligent	intelligent	ADJ
gs-4060	634	16	design	design	NOUN
gs-4060	634	17	of	of	ADP
gs-4060	634	18	compounds	compound	NOUN
gs-4060	634	19	to	to	PART
gs-4060	634	20	overcome	overcome	VERB
gs-4060	634	21	resistance	resistance	NOUN
gs-4060	634	22	.	.	PUNCT
gs-4060	635	1	when	when	SCONJ
gs-4060	635	2	a	a	DET
gs-4060	635	3	point	point	NOUN
gs-4060	635	4	mutation	mutation	NOUN
gs-4060	635	5	in	in	ADP
gs-4060	635	6	the	the	DET
gs-4060	635	7	kinase	kinase	PROPN
gs-4060	635	8	domain	domain	NOUN
gs-4060	635	9	prevents	prevent	VERB
gs-4060	635	10	a	a	DET
gs-4060	635	11	drug	drug	NOUN
gs-4060	635	12	from	from	ADP
gs-4060	635	13	binding	bind	VERB
gs-4060	635	14	,	,	PUNCT
gs-4060	635	15	structural	structural	ADJ
gs-4060	635	16	models	model	NOUN
gs-4060	635	17	can	can	AUX
gs-4060	635	18	show	show	VERB
gs-4060	635	19	which	which	PRON
gs-4060	635	20	chemical	chemical	NOUN
gs-4060	635	21	groups	group	NOUN
gs-4060	635	22	on	on	ADP
gs-4060	635	23	the	the	DET
gs-4060	635	24	drug	drug	NOUN
gs-4060	635	25	are	be	AUX
gs-4060	635	26	clashing	clash	VERB
gs-4060	635	27	with	with	ADP
gs-4060	635	28	the	the	DET
gs-4060	635	29	mutant	mutant	ADJ
gs-4060	635	30	residue	residue	NOUN
gs-4060	635	31	.	.	PUNCT
gs-4060	636	1	this	this	DET
gs-4060	636	2	knowledge	knowledge	NOUN
gs-4060	636	3	enables	enable	VERB
gs-4060	636	4	the	the	DET
gs-4060	636	5	synthesis	synthesis	NOUN
gs-4060	636	6	of	of	ADP
gs-4060	636	7	a	a	DET
gs-4060	636	8	new	new	ADJ
gs-4060	636	9	analog	analog	NOUN
gs-4060	636	10	with	with	ADP
gs-4060	636	11	a	a	DET
gs-4060	636	12	slightly	slightly	ADV
gs-4060	636	13	altered	alter	VERB
gs-4060	636	14	structure	structure	NOUN
gs-4060	636	15	that	that	PRON
gs-4060	636	16	accommodates	accommodate	VERB
gs-4060	636	17	or	or	CCONJ
gs-4060	636	18	avoids	avoid	VERB
gs-4060	636	19	the	the	DET
gs-4060	636	20	mutation	mutation	NOUN
gs-4060	636	21	,	,	PUNCT
gs-4060	636	22	thereby	thereby	ADV
gs-4060	636	23	restoring	restore	VERB
gs-4060	636	24	binding	binding	ADJ
gs-4060	636	25	affinity	affinity	NOUN
gs-4060	636	26	.	.	PUNCT
gs-4060	637	1	this	this	DET
gs-4060	637	2	iterative	iterative	NOUN
gs-4060	637	3	process	process	NOUN
gs-4060	637	4	of	of	ADP
gs-4060	637	5	structural	structural	ADJ
gs-4060	637	6	analysis	analysis	NOUN
gs-4060	637	7	and	and	CCONJ
gs-4060	637	8	chemical	chemical	NOUN
gs-4060	637	9	optimization	optimization	NOUN
gs-4060	637	10	is	be	AUX
gs-4060	637	11	a	a	DET
gs-4060	637	12	continuous	continuous	ADJ
gs-4060	637	13	feedback	feedback	NOUN
gs-4060	637	14	loop	loop	NOUN
gs-4060	637	15	,	,	PUNCT
gs-4060	637	16	turning	turn	VERB
gs-4060	637	17	the	the	DET
gs-4060	637	18	problem	problem	NOUN
gs-4060	637	19	of	of	ADP
gs-4060	637	20	resistance	resistance	NOUN
gs-4060	637	21	into	into	ADP
gs-4060	637	22	a	a	DET
gs-4060	637	23	solvable	solvable	ADJ
gs-4060	637	24	engineering	engineering	NOUN
gs-4060	637	25	challenge	challenge	NOUN
gs-4060	637	26	.	.	PUNCT
gs-4060	638	1	beyond	beyond	ADP
gs-4060	638	2	the	the	DET
gs-4060	638	3	genome	genome	NOUN
gs-4060	638	4	:	:	PUNCT
gs-4060	638	5	the	the	DET
gs-4060	638	6	epigenetic	epigenetic	ADJ
gs-4060	638	7	landscape	landscape	NOUN
gs-4060	638	8	as	as	ADP
gs-4060	638	9	a	a	DET
gs-4060	638	10	therapeutic	therapeutic	ADJ
gs-4060	638	11	frontier	frontier	NOUN
gs-4060	638	12	while	while	SCONJ
gs-4060	638	13	genetic	genetic	ADJ
gs-4060	638	14	mutations	mutation	NOUN
gs-4060	638	15	have	have	AUX
gs-4060	638	16	been	be	AUX
gs-4060	638	17	the	the	DET
gs-4060	638	18	primary	primary	ADJ
gs-4060	638	19	focus	focus	NOUN
gs-4060	638	20	of	of	ADP
gs-4060	638	21	targeted	target	VERB
gs-4060	638	22	therapy	therapy	NOUN
gs-4060	638	23	,	,	PUNCT
gs-4060	638	24	the	the	DET
gs-4060	638	25	regulation	regulation	NOUN
gs-4060	638	26	of	of	ADP
gs-4060	638	27	gene	gene	NOUN
gs-4060	638	28	expression	expression	NOUN
gs-4060	638	29	without	without	ADP
gs-4060	638	30	altering	alter	VERB
gs-4060	638	31	the	the	DET
gs-4060	638	32	dna	dna	PROPN
gs-4060	638	33	sequence	sequence	NOUN
gs-4060	638	34	itself	itself	PRON
gs-4060	638	35	—	—	PUNCT
gs-4060	638	36	epigenetics	epigenetic	NOUN
gs-4060	638	37	—	—	PUNCT
gs-4060	638	38	is	be	AUX
gs-4060	638	39	a	a	DET
gs-4060	638	40	critical	critical	ADJ
gs-4060	638	41	layer	layer	NOUN
gs-4060	638	42	of	of	ADP
gs-4060	638	43	cancer	cancer	NOUN
gs-4060	638	44	biology	biology	NOUN
gs-4060	638	45	and	and	CCONJ
gs-4060	638	46	a	a	DET
gs-4060	638	47	fertile	fertile	ADJ
gs-4060	638	48	ground	ground	NOUN
gs-4060	638	49	for	for	ADP
gs-4060	638	50	drug	drug	NOUN
gs-4060	638	51	discovery	discovery	NOUN
gs-4060	638	52	.	.	PUNCT
gs-4060	639	1	cancer	cancer	NOUN
gs-4060	639	2	cells	cell	NOUN
gs-4060	639	3	frequently	frequently	ADV
gs-4060	639	4	hijack	hijack	VERB
gs-4060	639	5	the	the	DET
gs-4060	639	6	epigenetic	epigenetic	ADJ
gs-4060	639	7	machinery	machinery	NOUN
gs-4060	639	8	to	to	PART
gs-4060	639	9	silence	silence	VERB
gs-4060	639	10	tumor	tumor	NOUN
gs-4060	639	11	suppressor	suppressor	NOUN
gs-4060	639	12	genes	gene	NOUN
gs-4060	639	13	and	and	CCONJ
gs-4060	639	14	activate	activate	VERB
gs-4060	639	15	oncogenic	oncogenic	ADJ
gs-4060	639	16	pathways	pathway	NOUN
gs-4060	639	17	,	,	PUNCT
gs-4060	639	18	creating	create	VERB
gs-4060	639	19	a	a	DET
gs-4060	639	20	heritable	heritable	ADJ
gs-4060	639	21	state	state	NOUN
gs-4060	639	22	of	of	ADP
gs-4060	639	23	dysregulation	dysregulation	NOUN
gs-4060	639	24	.	.	PUNCT
gs-4060	640	1	two	two	NUM
gs-4060	640	2	major	major	ADJ
gs-4060	640	3	classes	class	NOUN
gs-4060	640	4	of	of	ADP
gs-4060	640	5	epigenetic	epigenetic	ADJ
gs-4060	640	6	drugs	drug	NOUN
gs-4060	640	7	have	have	AUX
gs-4060	640	8	entered	enter	VERB
gs-4060	640	9	the	the	DET
gs-4060	640	10	clinical	clinical	ADJ
gs-4060	640	11	arena	arena	NOUN
gs-4060	640	12	:	:	PUNCT
gs-4060	640	13	dna	dna	PROPN
gs-4060	640	14	methyltransferase	methyltransferase	NOUN
gs-4060	640	15	inhibitors	inhibitor	NOUN
gs-4060	640	16	and	and	CCONJ
gs-4060	640	17	histone	histone	NOUN
gs-4060	640	18	deacetylase	deacetylase	NOUN
gs-4060	640	19	inhibitors	inhibitor	NOUN
gs-4060	640	20	.	.	PUNCT
gs-4060	641	1	initially	initially	ADV
gs-4060	641	2	,	,	PUNCT
gs-4060	641	3	these	these	DET
gs-4060	641	4	agents	agent	NOUN
gs-4060	641	5	were	be	AUX
gs-4060	641	6	viewed	view	VERB
gs-4060	641	7	as	as	ADP
gs-4060	641	8	broad	broad	ADV
gs-4060	641	9	-	-	PUNCT
gs-4060	641	10	acting	act	VERB
gs-4060	641	11	,	,	PUNCT
gs-4060	641	12	cytotoxic	cytotoxic	ADJ
gs-4060	641	13	drugs	drug	NOUN
gs-4060	641	14	,	,	PUNCT
gs-4060	641	15	capable	capable	ADJ
gs-4060	641	16	of	of	ADP
gs-4060	641	17	reactivating	reactivate	VERB
gs-4060	641	18	silenced	silence	VERB
gs-4060	641	19	tumor	tumor	NOUN
gs-4060	641	20	suppressor	suppressor	NOUN
gs-4060	641	21	genes	gene	NOUN
gs-4060	641	22	through	through	ADP
gs-4060	641	23	global	global	ADJ
gs-4060	641	24	dna	dna	PROPN
gs-4060	641	25	demethylation	demethylation	NOUN
gs-4060	641	26	or	or	CCONJ
gs-4060	641	27	histone	histone	NOUN
gs-4060	641	28	hyperacetylation	hyperacetylation	NOUN
gs-4060	641	29	.	.	PUNCT
gs-4060	642	1	however	however	ADV
gs-4060	642	2	,	,	PUNCT
gs-4060	642	3	a	a	DET
gs-4060	642	4	more	more	ADV
gs-4060	642	5	nuanced	nuanced	ADJ
gs-4060	642	6	understanding	understanding	NOUN
gs-4060	642	7	is	be	AUX
gs-4060	642	8	emerging	emerge	VERB
gs-4060	642	9	.	.	PUNCT
gs-4060	643	1	their	their	PRON
gs-4060	643	2	efficacy	efficacy	NOUN
gs-4060	643	3	,	,	PUNCT
gs-4060	643	4	particularly	particularly	ADV
gs-4060	643	5	in	in	ADP
gs-4060	643	6	combination	combination	NOUN
gs-4060	643	7	with	with	ADP
gs-4060	643	8	other	other	ADJ
gs-4060	643	9	therapies	therapy	NOUN
gs-4060	643	10	,	,	PUNCT
gs-4060	643	11	may	may	AUX
gs-4060	643	12	stem	stem	VERB
gs-4060	643	13	from	from	ADP
gs-4060	643	14	their	their	PRON
gs-4060	643	15	ability	ability	NOUN
gs-4060	643	16	to	to	PART
gs-4060	643	17	reverse	reverse	VERB
gs-4060	643	18	a	a	DET
gs-4060	643	19	specific	specific	ADJ
gs-4060	643	20	,	,	PUNCT
gs-4060	643	21	plastic	plastic	ADJ
gs-4060	643	22	cellular	cellular	ADJ
gs-4060	643	23	state	state	NOUN
gs-4060	643	24	.	.	PUNCT
gs-4060	644	1	for	for	ADP
gs-4060	644	2	example	example	NOUN
gs-4060	644	3	,	,	PUNCT
gs-4060	644	4	in	in	ADP
gs-4060	644	5	acute	acute	ADJ
gs-4060	644	6	myeloid	myeloid	ADJ
gs-4060	644	7	leukemia	leukemia	NOUN
gs-4060	644	8	,	,	PUNCT
gs-4060	644	9	hypomethylating	hypomethylate	VERB
gs-4060	644	10	agents	agent	NOUN
gs-4060	644	11	can	can	AUX
gs-4060	644	12	supposedly	supposedly	ADV
gs-4060	644	13	sensitize	sensitize	VERB
gs-4060	644	14	leukemic	leukemic	ADJ
gs-4060	644	15	stem	stem	NOUN
gs-4060	644	16	cells	cell	NOUN
gs-4060	644	17	to	to	ADP
gs-4060	644	18	differentiation	differentiation	NOUN
gs-4060	644	19	therapy	therapy	NOUN
gs-4060	644	20	by	by	ADP
gs-4060	644	21	making	make	VERB
gs-4060	644	22	their	their	PRON
gs-4060	644	23	chromatin	chromatin	NOUN
gs-4060	644	24	more	more	ADV
gs-4060	644	25	accessible	accessible	ADJ
gs-4060	644	26	,	,	PUNCT
gs-4060	644	27	priming	prime	VERB
gs-4060	644	28	them	they	PRON
gs-4060	644	29	to	to	PART
gs-4060	644	30	respond	respond	VERB
gs-4060	644	31	to	to	ADP
gs-4060	644	32	signals	signal	NOUN
gs-4060	644	33	that	that	PRON
gs-4060	644	34	drive	drive	VERB
gs-4060	644	35	them	they	PRON
gs-4060	644	36	out	out	ADP
gs-4060	644	37	of	of	ADP
gs-4060	644	38	georgian	georgian	PROPN
gs-4060	644	39	scientists/	scientists/	NUM
gs-4060	644	40	.	.	PUNCT
gs-4060	645	1	7	7	NUM
gs-4060	645	2	n	n	PRON
gs-4060	645	3	3	3	NUM
gs-4060	645	4	,	,	PUNCT
gs-4060	645	5	2025	2025	NUM
gs-4060	645	6	599	599	NUM
gs-4060	645	7	their	their	PRON
gs-4060	645	8	dormant	dormant	ADJ
gs-4060	645	9	,	,	PUNCT
gs-4060	645	10	therapy	therapy	NOUN
gs-4060	645	11	-	-	PUNCT
gs-4060	645	12	resistant	resistant	ADJ
gs-4060	645	13	state	state	NOUN
gs-4060	645	14	.	.	PUNCT
gs-4060	646	1	furthermore	furthermore	ADV
gs-4060	646	2	,	,	PUNCT
gs-4060	646	3	the	the	DET
gs-4060	646	4	tumor	tumor	NOUN
gs-4060	646	5	's	's	PART
gs-4060	646	6	epigenetic	epigenetic	ADJ
gs-4060	646	7	state	state	NOUN
gs-4060	646	8	is	be	AUX
gs-4060	646	9	a	a	DET
gs-4060	646	10	key	key	ADJ
gs-4060	646	11	regulator	regulator	NOUN
gs-4060	646	12	of	of	ADP
gs-4060	646	13	its	its	PRON
gs-4060	646	14	immunogenicity	immunogenicity	NOUN
gs-4060	646	15	.	.	PUNCT
gs-4060	647	1	silencing	silence	VERB
gs-4060	647	2	of	of	ADP
gs-4060	647	3	genes	gene	NOUN
gs-4060	647	4	involved	involve	VERB
gs-4060	647	5	in	in	ADP
gs-4060	647	6	antigen	antigen	ADJ
gs-4060	647	7	presentation	presentation	NOUN
gs-4060	647	8	is	be	AUX
gs-4060	647	9	a	a	DET
gs-4060	647	10	common	common	ADJ
gs-4060	647	11	immune	immune	ADJ
gs-4060	647	12	evasion	evasion	NOUN
gs-4060	647	13	strategy	strategy	NOUN
gs-4060	647	14	.	.	PUNCT
gs-4060	648	1	epigenetic	epigenetic	ADJ
gs-4060	648	2	therapies	therapy	NOUN
gs-4060	648	3	can	can	AUX
gs-4060	648	4	potentially	potentially	ADV
gs-4060	648	5	reverse	reverse	VERB
gs-4060	648	6	this	this	PRON
gs-4060	648	7	,	,	PUNCT
gs-4060	648	8	increasing	increase	VERB
gs-4060	648	9	the	the	DET
gs-4060	648	10	visibility	visibility	NOUN
gs-4060	648	11	of	of	ADP
gs-4060	648	12	the	the	DET
gs-4060	648	13	tumor	tumor	NOUN
gs-4060	648	14	to	to	ADP
gs-4060	648	15	the	the	DET
gs-4060	648	16	immune	immune	ADJ
gs-4060	648	17	system	system	NOUN
gs-4060	648	18	and	and	CCONJ
gs-4060	648	19	thereby	thereby	ADV
gs-4060	648	20	synergizing	synergize	VERB
gs-4060	648	21	powerfully	powerfully	ADV
gs-4060	648	22	with	with	ADP
gs-4060	648	23	checkpoint	checkpoint	NOUN
gs-4060	648	24	blockade	blockade	NOUN
gs-4060	648	25	.	.	PUNCT
gs-4060	649	1	this	this	PRON
gs-4060	649	2	has	have	AUX
gs-4060	649	3	led	lead	VERB
gs-4060	649	4	to	to	ADP
gs-4060	649	5	clinical	clinical	ADJ
gs-4060	649	6	trials	trial	NOUN
gs-4060	649	7	combining	combine	VERB
gs-4060	649	8	hdac	hdac	NOUN
gs-4060	649	9	or	or	CCONJ
gs-4060	649	10	dnmt	dnmt	NOUN
gs-4060	649	11	inhibitors	inhibitor	NOUN
gs-4060	649	12	with	with	ADP
gs-4060	649	13	anti	anti	ADJ
gs-4060	649	14	-	-	ADJ
gs-4060	649	15	pd-1	pd-1	ADJ
gs-4060	649	16	antibodies	antibody	NOUN
gs-4060	649	17	,	,	PUNCT
gs-4060	649	18	with	with	ADP
gs-4060	649	19	the	the	DET
gs-4060	649	20	goal	goal	NOUN
gs-4060	649	21	of	of	ADP
gs-4060	649	22	creating	create	VERB
gs-4060	649	23	a	a	DET
gs-4060	649	24	more	more	ADV
gs-4060	649	25	immunogenic	immunogenic	ADJ
gs-4060	649	26	tumor	tumor	NOUN
gs-4060	649	27	microenvironment	microenvironment	NOUN
gs-4060	649	28	.	.	PUNCT
gs-4060	650	1	the	the	DET
gs-4060	650	2	next	next	ADJ
gs-4060	650	3	frontier	frontier	NOUN
gs-4060	650	4	is	be	AUX
gs-4060	650	5	targeting	target	VERB
gs-4060	650	6	writers	writer	NOUN
gs-4060	650	7	,	,	PUNCT
gs-4060	650	8	readers	reader	NOUN
gs-4060	650	9	,	,	PUNCT
gs-4060	650	10	and	and	CCONJ
gs-4060	650	11	erasers	eraser	NOUN
gs-4060	650	12	of	of	ADP
gs-4060	650	13	specific	specific	ADJ
gs-4060	650	14	histone	histone	NOUN
gs-4060	650	15	marks	mark	NOUN
gs-4060	650	16	.	.	PUNCT
gs-4060	651	1	mutations	mutation	NOUN
gs-4060	651	2	in	in	ADP
gs-4060	651	3	genes	gene	NOUN
gs-4060	651	4	encoding	encode	VERB
gs-4060	651	5	epigenetic	epigenetic	ADJ
gs-4060	651	6	regulators	regulator	NOUN
gs-4060	651	7	,	,	PUNCT
gs-4060	651	8	such	such	ADJ
gs-4060	651	9	as	as	ADP
gs-4060	651	10	ezh2	ezh2	NOUN
gs-4060	651	11	(	(	PUNCT
gs-4060	651	12	a	a	DET
gs-4060	651	13	writer	writer	NOUN
gs-4060	651	14	of	of	ADP
gs-4060	651	15	repressive	repressive	ADJ
gs-4060	651	16	marks	mark	NOUN
gs-4060	651	17	)	)	PUNCT
gs-4060	651	18	or	or	CCONJ
gs-4060	651	19	idh1/2	idh1/2	PROPN
gs-4060	651	20	(	(	PUNCT
gs-4060	651	21	which	which	PRON
gs-4060	651	22	alter	alter	VERB
gs-4060	651	23	the	the	DET
gs-4060	651	24	epigenetic	epigenetic	ADJ
gs-4060	651	25	landscape	landscape	NOUN
gs-4060	651	26	by	by	ADP
gs-4060	651	27	producing	produce	VERB
gs-4060	651	28	an	an	DET
gs-4060	651	29	oncometabolite	oncometabolite	NOUN
gs-4060	651	30	)	)	PUNCT
gs-4060	651	31	,	,	PUNCT
gs-4060	651	32	create	create	VERB
gs-4060	651	33	direct	direct	ADJ
gs-4060	651	34	dependencies	dependency	NOUN
gs-4060	651	35	.	.	PUNCT
gs-4060	652	1	inhibitors	inhibitor	NOUN
gs-4060	652	2	of	of	ADP
gs-4060	652	3	mutant	mutant	NOUN
gs-4060	652	4	idh1/2	idh1/2	VERB
gs-4060	652	5	,	,	PUNCT
gs-4060	652	6	for	for	ADP
gs-4060	652	7	example	example	NOUN
gs-4060	652	8	,	,	PUNCT
gs-4060	652	9	cause	cause	VERB
gs-4060	652	10	differentiation	differentiation	NOUN
gs-4060	652	11	of	of	ADP
gs-4060	652	12	leukemic	leukemic	ADJ
gs-4060	652	13	blasts	blast	NOUN
gs-4060	652	14	by	by	ADP
gs-4060	652	15	reversing	reverse	VERB
gs-4060	652	16	the	the	DET
gs-4060	652	17	block	block	NOUN
gs-4060	652	18	in	in	ADP
gs-4060	652	19	cellular	cellular	ADJ
gs-4060	652	20	maturation	maturation	NOUN
gs-4060	652	21	imposed	impose	VERB
gs-4060	652	22	by	by	ADP
gs-4060	652	23	the	the	DET
gs-4060	652	24	mutant	mutant	ADJ
gs-4060	652	25	enzyme	enzyme	NOUN
gs-4060	652	26	.	.	PUNCT
gs-4060	653	1	these	these	DET
gs-4060	653	2	agents	agent	NOUN
gs-4060	653	3	represent	represent	VERB
gs-4060	653	4	a	a	DET
gs-4060	653	5	true	true	ADJ
gs-4060	653	6	targeted	target	VERB
gs-4060	653	7	therapy	therapy	NOUN
gs-4060	653	8	against	against	ADP
gs-4060	653	9	an	an	DET
gs-4060	653	10	epigenetic	epigenetic	ADJ
gs-4060	653	11	driver	driver	NOUN
gs-4060	653	12	,	,	PUNCT
gs-4060	653	13	demonstrating	demonstrate	VERB
gs-4060	653	14	that	that	SCONJ
gs-4060	653	15	epigenetic	epigenetic	ADJ
gs-4060	653	16	alterations	alteration	NOUN
gs-4060	653	17	can	can	AUX
gs-4060	653	18	be	be	AUX
gs-4060	653	19	as	as	ADV
gs-4060	653	20	critical	critical	ADJ
gs-4060	653	21	as	as	ADP
gs-4060	653	22	genetic	genetic	ADJ
gs-4060	653	23	mutations	mutation	NOUN
gs-4060	653	24	in	in	ADP
gs-4060	653	25	sustaining	sustain	VERB
gs-4060	653	26	the	the	DET
gs-4060	653	27	malignant	malignant	ADJ
gs-4060	653	28	state	state	NOUN
gs-4060	653	29	.	.	PUNCT
gs-4060	654	1	spatial	spatial	ADJ
gs-4060	654	2	biology	biology	NOUN
gs-4060	654	3	:	:	PUNCT
gs-4060	654	4	mapping	map	VERB
gs-4060	654	5	the	the	DET
gs-4060	654	6	tumor	tumor	NOUN
gs-4060	654	7	universe	universe	NOUN
gs-4060	654	8	traditional	traditional	ADJ
gs-4060	654	9	sequencing	sequencing	NOUN
gs-4060	654	10	technologies	technology	NOUN
gs-4060	654	11	,	,	PUNCT
gs-4060	654	12	which	which	PRON
gs-4060	654	13	homogenize	homogenize	VERB
gs-4060	654	14	a	a	DET
gs-4060	654	15	tissue	tissue	NOUN
gs-4060	654	16	sample	sample	NOUN
gs-4060	654	17	,	,	PUNCT
gs-4060	654	18	provide	provide	VERB
gs-4060	654	19	a	a	DET
gs-4060	654	20	wealth	wealth	NOUN
gs-4060	654	21	of	of	ADP
gs-4060	654	22	data	datum	NOUN
gs-4060	654	23	but	but	CCONJ
gs-4060	654	24	lose	lose	VERB
gs-4060	654	25	all	all	DET
gs-4060	654	26	information	information	NOUN
gs-4060	654	27	about	about	ADP
gs-4060	654	28	the	the	DET
gs-4060	654	29	spatial	spatial	ADJ
gs-4060	654	30	context	context	NOUN
gs-4060	654	31	of	of	ADP
gs-4060	654	32	cells	cell	NOUN
gs-4060	654	33	.	.	PUNCT
gs-4060	655	1	this	this	PRON
gs-4060	655	2	is	be	AUX
gs-4060	655	3	a	a	DET
gs-4060	655	4	critical	critical	ADJ
gs-4060	655	5	limitation	limitation	NOUN
gs-4060	655	6	,	,	PUNCT
gs-4060	655	7	as	as	SCONJ
gs-4060	655	8	the	the	DET
gs-4060	655	9	function	function	NOUN
gs-4060	655	10	of	of	ADP
gs-4060	655	11	a	a	DET
gs-4060	655	12	cell	cell	NOUN
gs-4060	655	13	is	be	AUX
gs-4060	655	14	intrinsically	intrinsically	ADV
gs-4060	655	15	linked	link	VERB
gs-4060	655	16	to	to	ADP
gs-4060	655	17	its	its	PRON
gs-4060	655	18	location	location	NOUN
gs-4060	655	19	and	and	CCONJ
gs-4060	655	20	its	its	PRON
gs-4060	655	21	neighbors	neighbor	NOUN
gs-4060	655	22	.	.	PUNCT
gs-4060	656	1	the	the	DET
gs-4060	656	2	emergence	emergence	NOUN
gs-4060	656	3	of	of	ADP
gs-4060	656	4	spatial	spatial	ADJ
gs-4060	656	5	transcriptomics	transcriptomic	NOUN
gs-4060	656	6	and	and	CCONJ
gs-4060	656	7	proteomics	proteomic	NOUN
gs-4060	656	8	represents	represent	VERB
gs-4060	656	9	a	a	DET
gs-4060	656	10	quantum	quantum	ADJ
gs-4060	656	11	leap	leap	NOUN
gs-4060	656	12	in	in	ADP
gs-4060	656	13	our	our	PRON
gs-4060	656	14	analytical	analytical	ADJ
gs-4060	656	15	capabilities	capability	NOUN
gs-4060	656	16	,	,	PUNCT
gs-4060	656	17	allowing	allow	VERB
gs-4060	656	18	scientists	scientist	NOUN
gs-4060	656	19	to	to	PART
gs-4060	656	20	map	map	VERB
gs-4060	656	21	the	the	DET
gs-4060	656	22	expression	expression	NOUN
gs-4060	656	23	of	of	ADP
gs-4060	656	24	thousands	thousand	NOUN
gs-4060	656	25	of	of	ADP
gs-4060	656	26	genes	gene	NOUN
gs-4060	656	27	or	or	CCONJ
gs-4060	656	28	proteins	protein	NOUN
gs-4060	656	29	directly	directly	ADV
gs-4060	656	30	onto	onto	ADP
gs-4060	656	31	a	a	DET
gs-4060	656	32	tissue	tissue	NOUN
gs-4060	656	33	section	section	NOUN
gs-4060	656	34	,	,	PUNCT
gs-4060	656	35	preserving	preserve	VERB
gs-4060	656	36	the	the	DET
gs-4060	656	37	architectural	architectural	ADJ
gs-4060	656	38	integrity	integrity	NOUN
gs-4060	656	39	of	of	ADP
gs-4060	656	40	the	the	DET
gs-4060	656	41	tumor	tumor	NOUN
gs-4060	656	42	.	.	PUNCT
gs-4060	657	1	this	this	DET
gs-4060	657	2	technology	technology	NOUN
gs-4060	657	3	is	be	AUX
gs-4060	657	4	revealing	reveal	VERB
gs-4060	657	5	the	the	DET
gs-4060	657	6	profound	profound	ADJ
gs-4060	657	7	functional	functional	ADJ
gs-4060	657	8	heterogeneity	heterogeneity	NOUN
gs-4060	657	9	within	within	ADP
gs-4060	657	10	tumors	tumor	NOUN
gs-4060	657	11	.	.	PUNCT
gs-4060	658	1	it	it	PRON
gs-4060	658	2	can	can	AUX
gs-4060	658	3	identify	identify	VERB
gs-4060	658	4	distinct	distinct	ADJ
gs-4060	658	5	neighborhoods	neighborhood	NOUN
gs-4060	658	6	or	or	CCONJ
gs-4060	658	7	"	"	PUNCT
gs-4060	658	8	niches	niche	NOUN
gs-4060	658	9	"	"	PUNCT
gs-4060	658	10	:	:	PUNCT
gs-4060	658	11	an	an	DET
gs-4060	658	12	immunosuppressive	immunosuppressive	ADJ
gs-4060	658	13	niche	niche	NOUN
gs-4060	658	14	dominated	dominate	VERB
gs-4060	658	15	by	by	ADP
gs-4060	658	16	cafs	cafs	NOUN
gs-4060	658	17	,	,	PUNCT
gs-4060	658	18	tregs	treg	NOUN
gs-4060	658	19	,	,	PUNCT
gs-4060	658	20	and	and	CCONJ
gs-4060	658	21	m2	m2	PROPN
gs-4060	658	22	macrophages	macrophage	NOUN
gs-4060	658	23	;	;	PUNCT
gs-4060	658	24	an	an	DET
gs-4060	658	25	immunogenic	immunogenic	ADJ
gs-4060	658	26	"	"	PUNCT
gs-4060	658	27	tertiary	tertiary	ADJ
gs-4060	658	28	lymphoid	lymphoid	NOUN
gs-4060	658	29	structure	structure	NOUN
gs-4060	658	30	"	"	PUNCT
gs-4060	658	31	niche	niche	NOUN
gs-4060	658	32	rich	rich	ADJ
gs-4060	658	33	in	in	ADP
gs-4060	658	34	b	b	NOUN
gs-4060	658	35	-	-	PUNCT
gs-4060	658	36	cells	cell	NOUN
gs-4060	658	37	and	and	CCONJ
gs-4060	658	38	t	t	NOUN
gs-4060	658	39	-	-	PUNCT
gs-4060	658	40	cells	cell	NOUN
gs-4060	658	41	;	;	PUNCT
gs-4060	658	42	or	or	CCONJ
gs-4060	658	43	a	a	DET
gs-4060	658	44	hypoxic	hypoxic	ADJ
gs-4060	658	45	,	,	PUNCT
gs-4060	658	46	necrotic	necrotic	ADJ
gs-4060	658	47	core	core	NOUN
gs-4060	658	48	.	.	PUNCT
gs-4060	659	1	understanding	understand	VERB
gs-4060	659	2	the	the	DET
gs-4060	659	3	geography	geography	NOUN
gs-4060	659	4	of	of	ADP
gs-4060	659	5	the	the	DET
gs-4060	659	6	tme	tme	NOUN
gs-4060	659	7	explains	explain	VERB
gs-4060	659	8	why	why	SCONJ
gs-4060	659	9	some	some	DET
gs-4060	659	10	regions	region	NOUN
gs-4060	659	11	respond	respond	VERB
gs-4060	659	12	to	to	ADP
gs-4060	659	13	therapy	therapy	NOUN
gs-4060	659	14	while	while	SCONJ
gs-4060	659	15	others	other	NOUN
gs-4060	659	16	serve	serve	VERB
gs-4060	659	17	as	as	ADP
gs-4060	659	18	reservoirs	reservoir	NOUN
gs-4060	659	19	for	for	ADP
gs-4060	659	20	resistance	resistance	NOUN
gs-4060	659	21	.	.	PUNCT
gs-4060	660	1	for	for	ADP
gs-4060	660	2	instance	instance	NOUN
gs-4060	660	3	,	,	PUNCT
gs-4060	660	4	spatial	spatial	ADJ
gs-4060	660	5	analysis	analysis	NOUN
gs-4060	660	6	can	can	AUX
gs-4060	660	7	show	show	VERB
gs-4060	660	8	that	that	SCONJ
gs-4060	660	9	cancer	cancer	NOUN
gs-4060	660	10	cells	cell	NOUN
gs-4060	660	11	on	on	ADP
gs-4060	660	12	the	the	DET
gs-4060	660	13	invasive	invasive	ADJ
gs-4060	660	14	margin	margin	NOUN
gs-4060	660	15	,	,	PUNCT
gs-4060	660	16	interacting	interact	VERB
gs-4060	660	17	with	with	ADP
gs-4060	660	18	immune	immune	ADJ
gs-4060	660	19	cells	cell	NOUN
gs-4060	660	20	,	,	PUNCT
gs-4060	660	21	have	have	VERB
gs-4060	660	22	a	a	DET
gs-4060	660	23	different	different	ADJ
gs-4060	660	24	transcriptional	transcriptional	NOUN
gs-4060	660	25	profile	profile	NOUN
gs-4060	660	26	than	than	ADP
gs-4060	660	27	cells	cell	NOUN
gs-4060	660	28	in	in	ADP
gs-4060	660	29	the	the	DET
gs-4060	660	30	core	core	NOUN
gs-4060	660	31	,	,	PUNCT
gs-4060	660	32	interacting	interact	VERB
gs-4060	660	33	with	with	ADP
gs-4060	660	34	stroma	stroma	NOUN
gs-4060	660	35	.	.	PUNCT
gs-4060	661	1	this	this	PRON
gs-4060	661	2	has	have	VERB
gs-4060	661	3	direct	direct	ADJ
gs-4060	661	4	clinical	clinical	ADJ
gs-4060	661	5	implications	implication	NOUN
gs-4060	661	6	.	.	PUNCT
gs-4060	662	1	a	a	DET
gs-4060	662	2	simple	simple	ADJ
gs-4060	662	3	measurement	measurement	NOUN
gs-4060	662	4	of	of	ADP
gs-4060	662	5	pd	pd	PROPN
gs-4060	662	6	-	-	PROPN
gs-4060	662	7	l1	l1	PROPN
gs-4060	662	8	expression	expression	NOUN
gs-4060	662	9	on	on	ADP
gs-4060	662	10	a	a	DET
gs-4060	662	11	bulk	bulk	ADJ
gs-4060	662	12	sample	sample	NOUN
gs-4060	662	13	is	be	AUX
gs-4060	662	14	a	a	DET
gs-4060	662	15	crude	crude	ADJ
gs-4060	662	16	predictor	predictor	NOUN
gs-4060	662	17	of	of	ADP
gs-4060	662	18	response	response	NOUN
gs-4060	662	19	to	to	ADP
gs-4060	662	20	immunotherapy	immunotherapy	NOUN
gs-4060	662	21	.	.	PUNCT
gs-4060	663	1	spatial	spatial	ADJ
gs-4060	663	2	biology	biology	NOUN
gs-4060	663	3	can	can	AUX
gs-4060	663	4	quantify	quantify	VERB
gs-4060	663	5	not	not	PART
gs-4060	663	6	just	just	ADV
gs-4060	663	7	if	if	SCONJ
gs-4060	663	8	pd	pd	PROPN
gs-4060	663	9	-	-	PROPN
gs-4060	663	10	l1	l1	PROPN
gs-4060	663	11	is	be	AUX
gs-4060	663	12	expressed	express	VERB
gs-4060	663	13	,	,	PUNCT
gs-4060	663	14	but	but	CCONJ
gs-4060	663	15	where	where	SCONJ
gs-4060	663	16	and	and	CCONJ
gs-4060	663	17	by	by	ADP
gs-4060	663	18	whom	whom	PRON
gs-4060	663	19	—	—	PUNCT
gs-4060	663	20	whether	whether	SCONJ
gs-4060	663	21	it	it	PRON
gs-4060	663	22	is	be	AUX
gs-4060	663	23	on	on	ADP
gs-4060	663	24	tumor	tumor	NOUN
gs-4060	663	25	cells	cell	NOUN
gs-4060	663	26	or	or	CCONJ
gs-4060	663	27	immune	immune	ADJ
gs-4060	663	28	cells	cell	NOUN
gs-4060	663	29	and	and	CCONJ
gs-4060	663	30	within	within	ADP
gs-4060	663	31	what	what	DET
gs-4060	663	32	kind	kind	NOUN
gs-4060	663	33	of	of	ADP
gs-4060	663	34	cellular	cellular	ADJ
gs-4060	663	35	neighborhood	neighborhood	NOUN
gs-4060	663	36	.	.	PUNCT
gs-4060	664	1	this	this	DET
gs-4060	664	2	granular	granular	ADJ
gs-4060	664	3	level	level	NOUN
gs-4060	664	4	of	of	ADP
gs-4060	664	5	detail	detail	NOUN
gs-4060	664	6	is	be	AUX
gs-4060	664	7	likely	likely	ADJ
gs-4060	664	8	to	to	PART
gs-4060	664	9	yield	yield	VERB
gs-4060	664	10	far	far	ADV
gs-4060	664	11	more	more	ADV
gs-4060	664	12	powerful	powerful	ADJ
gs-4060	664	13	predictive	predictive	ADJ
gs-4060	664	14	biomarkers	biomarker	NOUN
gs-4060	664	15	.	.	PUNCT
gs-4060	665	1	furthermore	furthermore	ADV
gs-4060	665	2	,	,	PUNCT
gs-4060	665	3	spatial	spatial	ADJ
gs-4060	665	4	mapping	mapping	NOUN
gs-4060	665	5	is	be	AUX
gs-4060	665	6	elucidating	elucidate	VERB
gs-4060	665	7	the	the	DET
gs-4060	665	8	mechanisms	mechanism	NOUN
gs-4060	665	9	of	of	ADP
gs-4060	665	10	adaptive	adaptive	ADJ
gs-4060	665	11	resistance	resistance	NOUN
gs-4060	665	12	.	.	PUNCT
gs-4060	666	1	by	by	ADP
gs-4060	666	2	analyzing	analyze	VERB
gs-4060	666	3	paired	pair	VERB
gs-4060	666	4	biopsies	biopsy	NOUN
gs-4060	666	5	before	before	ADP
gs-4060	666	6	and	and	CCONJ
gs-4060	666	7	during	during	ADP
gs-4060	666	8	treatment	treatment	NOUN
gs-4060	666	9	,	,	PUNCT
gs-4060	666	10	researchers	researcher	NOUN
gs-4060	666	11	can	can	AUX
gs-4060	666	12	observe	observe	VERB
gs-4060	666	13	how	how	SCONJ
gs-4060	666	14	the	the	DET
gs-4060	666	15	tumor	tumor	NOUN
gs-4060	666	16	geography	geography	NOUN
gs-4060	666	17	shifts	shift	NOUN
gs-4060	666	18	in	in	ADP
gs-4060	666	19	response	response	NOUN
gs-4060	666	20	to	to	ADP
gs-4060	666	21	therapeutic	therapeutic	ADJ
gs-4060	666	22	pressure	pressure	NOUN
gs-4060	666	23	.	.	PUNCT
gs-4060	667	1	for	for	ADP
gs-4060	667	2	example	example	NOUN
gs-4060	667	3	,	,	PUNCT
gs-4060	667	4	a	a	DET
gs-4060	667	5	tumor	tumor	NOUN
gs-4060	667	6	might	might	AUX
gs-4060	667	7	respond	respond	VERB
gs-4060	667	8	to	to	ADP
gs-4060	667	9	a	a	DET
gs-4060	667	10	targeted	target	VERB
gs-4060	667	11	therapy	therapy	NOUN
gs-4060	667	12	by	by	ADP
gs-4060	667	13	increasing	increase	VERB
gs-4060	667	14	the	the	DET
gs-4060	667	15	density	density	NOUN
gs-4060	667	16	of	of	ADP
gs-4060	667	17	protective	protective	ADJ
gs-4060	667	18	cafs	cafs	NOUN
gs-4060	667	19	around	around	ADP
gs-4060	667	20	persistent	persistent	ADJ
gs-4060	667	21	cell	cell	NOUN
gs-4060	667	22	clusters	cluster	NOUN
gs-4060	667	23	or	or	CCONJ
gs-4060	667	24	recruiting	recruit	VERB
gs-4060	667	25	different	different	ADJ
gs-4060	667	26	immunosuppressive	immunosuppressive	ADJ
gs-4060	667	27	myeloid	myeloid	ADJ
gs-4060	667	28	populations	population	NOUN
gs-4060	667	29	to	to	PART
gs-4060	667	30	shield	shield	VERB
gs-4060	667	31	itself	itself	PRON
gs-4060	667	32	from	from	ADP
gs-4060	667	33	the	the	DET
gs-4060	667	34	immune	immune	ADJ
gs-4060	667	35	system	system	NOUN
gs-4060	667	36	.	.	PUNCT
gs-4060	668	1	this	this	DET
gs-4060	668	2	dynamic	dynamic	ADJ
gs-4060	668	3	view	view	NOUN
gs-4060	668	4	of	of	ADP
gs-4060	668	5	resistance	resistance	NOUN
gs-4060	668	6	provides	provide	VERB
gs-4060	668	7	a	a	DET
gs-4060	668	8	new	new	ADJ
gs-4060	668	9	set	set	NOUN
gs-4060	668	10	of	of	ADP
gs-4060	668	11	tangible	tangible	ADJ
gs-4060	668	12	targets	target	NOUN
gs-4060	668	13	for	for	ADP
gs-4060	668	14	rational	rational	ADJ
gs-4060	668	15	combination	combination	NOUN
gs-4060	668	16	therapies	therapy	NOUN
gs-4060	668	17	designed	design	VERB
gs-4060	668	18	to	to	PART
gs-4060	668	19	prevent	prevent	VERB
gs-4060	668	20	the	the	DET
gs-4060	668	21	tumor	tumor	NOUN
gs-4060	668	22	from	from	ADP
gs-4060	668	23	reorganizing	reorganize	VERB
gs-4060	668	24	its	its	PRON
gs-4060	668	25	defenses	defense	NOUN
gs-4060	668	26	.	.	PUNCT
gs-4060	669	1	georgian	georgian	NOUN
gs-4060	669	2	scientists/	scientists/	NUM
gs-4060	669	3	.	.	PUNCT
gs-4060	670	1	7	7	NUM
gs-4060	670	2	n	n	PRON
gs-4060	670	3	3	3	NUM
gs-4060	670	4	,	,	PUNCT
gs-4060	670	5	2025	2025	NUM
gs-4060	670	6	600	600	NUM
gs-4060	670	7	philosophical	philosophical	ADJ
gs-4060	670	8	shifts	shift	NOUN
gs-4060	670	9	:	:	PUNCT
gs-4060	670	10	from	from	ADP
gs-4060	670	11	maximum	maximum	ADJ
gs-4060	670	12	tolerated	tolerate	VERB
gs-4060	670	13	dose	dose	NOUN
gs-4060	670	14	to	to	ADP
gs-4060	670	15	optimal	optimal	ADJ
gs-4060	670	16	biological	biological	NOUN
gs-4060	670	17	dose	dose	NOUN
gs-4060	670	18	the	the	DET
gs-4060	670	19	clinical	clinical	ADJ
gs-4060	670	20	development	development	NOUN
gs-4060	670	21	of	of	ADP
gs-4060	670	22	cytotoxic	cytotoxic	ADJ
gs-4060	670	23	chemotherapy	chemotherapy	NOUN
gs-4060	670	24	was	be	AUX
gs-4060	670	25	guided	guide	VERB
gs-4060	670	26	by	by	ADP
gs-4060	670	27	the	the	DET
gs-4060	670	28	principle	principle	NOUN
gs-4060	670	29	of	of	ADP
gs-4060	670	30	the	the	DET
gs-4060	670	31	maximum	maximum	ADJ
gs-4060	670	32	tolerated	tolerate	VERB
gs-4060	670	33	dose	dose	NOUN
gs-4060	670	34	:	:	PUNCT
gs-4060	670	35	the	the	DET
gs-4060	670	36	highest	high	ADJ
gs-4060	670	37	dose	dose	NOUN
gs-4060	670	38	that	that	PRON
gs-4060	670	39	does	do	AUX
gs-4060	670	40	not	not	PART
gs-4060	670	41	cause	cause	VERB
gs-4060	670	42	unacceptable	unacceptable	ADJ
gs-4060	670	43	toxicity	toxicity	NOUN
gs-4060	670	44	.	.	PUNCT
gs-4060	671	1	this	this	PRON
gs-4060	671	2	made	make	VERB
gs-4060	671	3	sense	sense	NOUN
gs-4060	671	4	for	for	ADP
gs-4060	671	5	non	non	ADJ
gs-4060	671	6	-	-	ADJ
gs-4060	671	7	selective	selective	ADJ
gs-4060	671	8	agents	agent	NOUN
gs-4060	671	9	where	where	SCONJ
gs-4060	671	10	the	the	DET
gs-4060	671	11	goal	goal	NOUN
gs-4060	671	12	was	be	AUX
gs-4060	671	13	to	to	PART
gs-4060	671	14	kill	kill	VERB
gs-4060	671	15	as	as	ADV
gs-4060	671	16	many	many	ADJ
gs-4060	671	17	cancer	cancer	NOUN
gs-4060	671	18	cells	cell	NOUN
gs-4060	671	19	as	as	ADP
gs-4060	671	20	possible	possible	ADJ
gs-4060	671	21	in	in	ADP
gs-4060	671	22	a	a	DET
gs-4060	671	23	short	short	ADJ
gs-4060	671	24	period	period	NOUN
gs-4060	671	25	,	,	PUNCT
gs-4060	671	26	with	with	ADP
gs-4060	671	27	recovery	recovery	NOUN
gs-4060	671	28	periods	period	NOUN
gs-4060	671	29	between	between	ADP
gs-4060	671	30	cycles	cycle	NOUN
gs-4060	671	31	.	.	PUNCT
gs-4060	672	1	this	this	DET
gs-4060	672	2	philosophy	philosophy	NOUN
gs-4060	672	3	is	be	AUX
gs-4060	672	4	increasingly	increasingly	ADV
gs-4060	672	5	obsolete	obsolete	ADJ
gs-4060	672	6	for	for	ADP
gs-4060	672	7	the	the	DET
gs-4060	672	8	new	new	ADJ
gs-4060	672	9	generation	generation	NOUN
gs-4060	672	10	of	of	ADP
gs-4060	672	11	drugs	drug	NOUN
gs-4060	672	12	.	.	PUNCT
gs-4060	673	1	for	for	ADP
gs-4060	673	2	many	many	ADJ
gs-4060	673	3	targeted	target	VERB
gs-4060	673	4	agents	agent	NOUN
gs-4060	673	5	,	,	PUNCT
gs-4060	673	6	the	the	DET
gs-4060	673	7	relationship	relationship	NOUN
gs-4060	673	8	between	between	ADP
gs-4060	673	9	dose	dose	PROPN
gs-4060	673	10	and	and	CCONJ
gs-4060	673	11	antitumor	antitumor	PROPN
gs-4060	673	12	effect	effect	NOUN
gs-4060	673	13	is	be	AUX
gs-4060	673	14	not	not	PART
gs-4060	673	15	linear	linear	ADJ
gs-4060	673	16	.	.	PUNCT
gs-4060	674	1	target	target	NOUN
gs-4060	674	2	saturation	saturation	NOUN
gs-4060	674	3	often	often	ADV
gs-4060	674	4	occurs	occur	VERB
gs-4060	674	5	at	at	ADP
gs-4060	674	6	doses	dose	NOUN
gs-4060	674	7	well	well	ADV
gs-4060	674	8	below	below	ADP
gs-4060	674	9	the	the	DET
gs-4060	674	10	mtd	mtd	PROPN
gs-4060	674	11	.	.	PUNCT
gs-4060	675	1	once	once	SCONJ
gs-4060	675	2	the	the	DET
gs-4060	675	3	target	target	NOUN
gs-4060	675	4	is	be	AUX
gs-4060	675	5	fully	fully	ADV
gs-4060	675	6	engaged	engage	VERB
gs-4060	675	7	,	,	PUNCT
gs-4060	675	8	increasing	increase	VERB
gs-4060	675	9	the	the	DET
gs-4060	675	10	dose	dose	NOUN
gs-4060	675	11	may	may	AUX
gs-4060	675	12	not	not	PART
gs-4060	675	13	yield	yield	VERB
gs-4060	675	14	greater	great	ADJ
gs-4060	675	15	efficacy	efficacy	NOUN
gs-4060	675	16	but	but	CCONJ
gs-4060	675	17	will	will	AUX
gs-4060	675	18	almost	almost	ADV
gs-4060	675	19	certainly	certainly	ADV
gs-4060	675	20	increase	increase	VERB
gs-4060	675	21	off	off	ADP
gs-4060	675	22	-	-	PUNCT
gs-4060	675	23	target	target	NOUN
gs-4060	675	24	toxicities	toxicity	NOUN
gs-4060	675	25	.	.	PUNCT
gs-4060	676	1	this	this	PRON
gs-4060	676	2	has	have	AUX
gs-4060	676	3	led	lead	VERB
gs-4060	676	4	to	to	ADP
gs-4060	676	5	the	the	DET
gs-4060	676	6	concept	concept	NOUN
gs-4060	676	7	of	of	ADP
gs-4060	676	8	finding	find	VERB
gs-4060	676	9	the	the	DET
gs-4060	676	10	"	"	PUNCT
gs-4060	676	11	optimal	optimal	ADJ
gs-4060	676	12	biological	biological	ADJ
gs-4060	676	13	dose	dose	NOUN
gs-4060	676	14	"	"	PUNCT
gs-4060	676	15	or	or	CCONJ
gs-4060	676	16	"	"	PUNCT
gs-4060	676	17	pharmacologically	pharmacologically	ADV
gs-4060	676	18	active	active	ADJ
gs-4060	676	19	dose	dose	NOUN
gs-4060	676	20	"	"	PUNCT
gs-4060	676	21	in	in	ADP
gs-4060	676	22	early	early	ADJ
gs-4060	676	23	-	-	PUNCT
gs-4060	676	24	phase	phase	NOUN
gs-4060	676	25	trials	trial	NOUN
gs-4060	676	26	.	.	PUNCT
gs-4060	677	1	this	this	PRON
gs-4060	677	2	involves	involve	VERB
gs-4060	677	3	using	use	VERB
gs-4060	677	4	pharmacodynamic	pharmacodynamic	ADJ
gs-4060	677	5	biomarkers	biomarker	NOUN
gs-4060	677	6	—	—	PUNCT
gs-4060	677	7	such	such	ADJ
gs-4060	677	8	as	as	ADP
gs-4060	677	9	the	the	DET
gs-4060	677	10	degree	degree	NOUN
gs-4060	677	11	of	of	ADP
gs-4060	677	12	target	target	NOUN
gs-4060	677	13	inhibition	inhibition	NOUN
gs-4060	677	14	in	in	ADP
gs-4060	677	15	tumor	tumor	NOUN
gs-4060	677	16	tissue	tissue	NOUN
gs-4060	677	17	or	or	CCONJ
gs-4060	677	18	surrogate	surrogate	ADJ
gs-4060	677	19	tissues	tissue	NOUN
gs-4060	677	20	,	,	PUNCT
gs-4060	677	21	or	or	CCONJ
gs-4060	677	22	changes	change	NOUN
gs-4060	677	23	in	in	ADP
gs-4060	677	24	downstream	downstream	ADJ
gs-4060	677	25	signaling	signal	VERB
gs-4060	677	26	molecules	molecule	NOUN
gs-4060	677	27	in	in	ADP
gs-4060	677	28	the	the	DET
gs-4060	677	29	blood	blood	NOUN
gs-4060	677	30	—	—	PUNCT
gs-4060	677	31	to	to	PART
gs-4060	677	32	identify	identify	VERB
gs-4060	677	33	the	the	DET
gs-4060	677	34	dose	dose	NOUN
gs-4060	677	35	that	that	PRON
gs-4060	677	36	achieves	achieve	VERB
gs-4060	677	37	the	the	DET
gs-4060	677	38	desired	desire	VERB
gs-4060	677	39	biological	biological	ADJ
gs-4060	677	40	effect	effect	NOUN
gs-4060	677	41	,	,	PUNCT
gs-4060	677	42	which	which	PRON
gs-4060	677	43	may	may	AUX
gs-4060	677	44	then	then	ADV
gs-4060	677	45	be	be	AUX
gs-4060	677	46	recommended	recommend	VERB
gs-4060	677	47	for	for	ADP
gs-4060	677	48	phase	phase	NOUN
gs-4060	677	49	ii	ii	PROPN
gs-4060	677	50	and	and	CCONJ
gs-4060	677	51	iii	iii	NUM
gs-4060	677	52	development	development	NOUN
gs-4060	677	53	.	.	PUNCT
gs-4060	678	1	this	this	DET
gs-4060	678	2	approach	approach	NOUN
gs-4060	678	3	prioritizes	prioritize	VERB
gs-4060	678	4	a	a	DET
gs-4060	678	5	drug	drug	NOUN
gs-4060	678	6	's	's	PART
gs-4060	678	7	mechanism	mechanism	NOUN
gs-4060	678	8	of	of	ADP
gs-4060	678	9	action	action	NOUN
gs-4060	678	10	over	over	ADP
gs-4060	678	11	its	its	PRON
gs-4060	678	12	brute	brute	ADJ
gs-4060	678	13	force	force	NOUN
gs-4060	678	14	,	,	PUNCT
gs-4060	678	15	potentially	potentially	ADV
gs-4060	678	16	leading	lead	VERB
gs-4060	678	17	to	to	ADP
gs-4060	678	18	regimens	regimen	NOUN
gs-4060	678	19	that	that	PRON
gs-4060	678	20	are	be	AUX
gs-4060	678	21	both	both	CCONJ
gs-4060	678	22	more	more	ADV
gs-4060	678	23	effective	effective	ADJ
gs-4060	678	24	and	and	CCONJ
gs-4060	678	25	better	well	ADV
gs-4060	678	26	tolerated	tolerate	VERB
gs-4060	678	27	.	.	PUNCT
gs-4060	679	1	for	for	ADP
gs-4060	679	2	some	some	DET
gs-4060	679	3	drugs	drug	NOUN
gs-4060	679	4	,	,	PUNCT
gs-4060	679	5	continuous	continuous	ADJ
gs-4060	679	6	daily	daily	ADJ
gs-4060	679	7	dosing	dosing	NOUN
gs-4060	679	8	applies	apply	VERB
gs-4060	679	9	such	such	ADJ
gs-4060	679	10	strong	strong	ADJ
gs-4060	679	11	selective	selective	ADJ
gs-4060	679	12	pressure	pressure	NOUN
gs-4060	679	13	that	that	PRON
gs-4060	679	14	it	it	PRON
gs-4060	679	15	rapidly	rapidly	ADV
gs-4060	679	16	encourages	encourage	VERB
gs-4060	679	17	the	the	DET
gs-4060	679	18	outgrowth	outgrowth	NOUN
gs-4060	679	19	of	of	ADP
gs-4060	679	20	resistant	resistant	ADJ
gs-4060	679	21	clones	clone	NOUN
gs-4060	679	22	.	.	PUNCT
gs-4060	680	1	preclinical	preclinical	ADJ
gs-4060	680	2	models	model	NOUN
gs-4060	680	3	and	and	CCONJ
gs-4060	680	4	some	some	DET
gs-4060	680	5	clinical	clinical	ADJ
gs-4060	680	6	observations	observation	NOUN
gs-4060	680	7	suggest	suggest	VERB
gs-4060	680	8	that	that	SCONJ
gs-4060	680	9	pulsatile	pulsatile	NOUN
gs-4060	680	10	,	,	PUNCT
gs-4060	680	11	high	high	ADJ
gs-4060	680	12	-	-	PUNCT
gs-4060	680	13	dose	dose	NOUN
gs-4060	680	14	scheduling	scheduling	NOUN
gs-4060	680	15	—	—	PUNCT
gs-4060	680	16	periods	period	NOUN
gs-4060	680	17	of	of	ADP
gs-4060	680	18	intense	intense	ADJ
gs-4060	680	19	target	target	NOUN
gs-4060	680	20	inhibition	inhibition	NOUN
gs-4060	680	21	followed	follow	VERB
gs-4060	680	22	by	by	ADP
gs-4060	680	23	treatment	treatment	NOUN
gs-4060	680	24	-	-	PUNCT
gs-4060	680	25	free	free	ADJ
gs-4060	680	26	intervals	interval	NOUN
gs-4060	680	27	—	—	PUNCT
gs-4060	680	28	could	could	AUX
gs-4060	680	29	allow	allow	VERB
gs-4060	680	30	for	for	ADP
gs-4060	680	31	the	the	DET
gs-4060	680	32	effective	effective	ADJ
gs-4060	680	33	killing	killing	NOUN
gs-4060	680	34	of	of	ADP
gs-4060	680	35	cancer	cancer	NOUN
gs-4060	680	36	cells	cell	NOUN
gs-4060	680	37	while	while	SCONJ
gs-4060	680	38	permitting	permit	VERB
gs-4060	680	39	sensitive	sensitive	ADJ
gs-4060	680	40	cells	cell	NOUN
gs-4060	680	41	(	(	PUNCT
gs-4060	680	42	which	which	PRON
gs-4060	680	43	may	may	AUX
gs-4060	680	44	have	have	VERB
gs-4060	680	45	a	a	DET
gs-4060	680	46	fitness	fitness	NOUN
gs-4060	680	47	advantage	advantage	NOUN
gs-4060	680	48	)	)	PUNCT
gs-4060	680	49	to	to	PART
gs-4060	680	50	repopulate	repopulate	VERB
gs-4060	680	51	during	during	ADP
gs-4060	680	52	the	the	DET
gs-4060	680	53	break	break	NOUN
gs-4060	680	54	,	,	PUNCT
gs-4060	680	55	thereby	thereby	ADV
gs-4060	680	56	suppressing	suppress	VERB
gs-4060	680	57	the	the	DET
gs-4060	680	58	expansion	expansion	NOUN
gs-4060	680	59	of	of	ADP
gs-4060	680	60	resistant	resistant	ADJ
gs-4060	680	61	populations	population	NOUN
gs-4060	680	62	.	.	PUNCT
gs-4060	681	1	this	this	DET
gs-4060	681	2	"	"	PUNCT
gs-4060	681	3	adaptive	adaptive	ADJ
gs-4060	681	4	therapy	therapy	NOUN
gs-4060	681	5	"	"	PUNCT
gs-4060	681	6	approach	approach	NOUN
gs-4060	681	7	,	,	PUNCT
gs-4060	681	8	borrowed	borrow	VERB
gs-4060	681	9	from	from	ADP
gs-4060	681	10	ecology	ecology	NOUN
gs-4060	681	11	,	,	PUNCT
gs-4060	681	12	aims	aim	VERB
gs-4060	681	13	to	to	PART
gs-4060	681	14	maintain	maintain	VERB
gs-4060	681	15	a	a	DET
gs-4060	681	16	stable	stable	ADJ
gs-4060	681	17	,	,	PUNCT
gs-4060	681	18	manageable	manageable	ADJ
gs-4060	681	19	tumor	tumor	NOUN
gs-4060	681	20	burden	burden	NOUN
gs-4060	681	21	rather	rather	ADV
gs-4060	681	22	than	than	ADP
gs-4060	681	23	pursuing	pursue	VERB
gs-4060	681	24	eradication	eradication	NOUN
gs-4060	681	25	,	,	PUNCT
gs-4060	681	26	which	which	PRON
gs-4060	681	27	may	may	AUX
gs-4060	681	28	be	be	AUX
gs-4060	681	29	an	an	DET
gs-4060	681	30	unattainable	unattainable	ADJ
gs-4060	681	31	goal	goal	NOUN
gs-4060	681	32	that	that	PRON
gs-4060	681	33	inadvertently	inadvertently	ADV
gs-4060	681	34	leads	lead	VERB
gs-4060	681	35	to	to	ADP
gs-4060	681	36	more	more	ADV
gs-4060	681	37	aggressive	aggressive	ADJ
gs-4060	681	38	resistance	resistance	NOUN
gs-4060	681	39	.	.	PUNCT
gs-4060	682	1	this	this	PRON
gs-4060	682	2	represents	represent	VERB
gs-4060	682	3	a	a	DET
gs-4060	682	4	profound	profound	ADJ
gs-4060	682	5	philosophical	philosophical	ADJ
gs-4060	682	6	shift	shift	NOUN
gs-4060	682	7	:	:	PUNCT
gs-4060	682	8	from	from	ADP
gs-4060	682	9	a	a	DET
gs-4060	682	10	war	war	NOUN
gs-4060	682	11	of	of	ADP
gs-4060	682	12	annihilation	annihilation	NOUN
gs-4060	682	13	to	to	ADP
gs-4060	682	14	a	a	DET
gs-4060	682	15	strategy	strategy	NOUN
gs-4060	682	16	of	of	ADP
gs-4060	682	17	long	long	ADJ
gs-4060	682	18	-	-	PUNCT
gs-4060	682	19	term	term	NOUN
gs-4060	682	20	containment	containment	NOUN
gs-4060	682	21	,	,	PUNCT
gs-4060	682	22	managing	manage	VERB
gs-4060	682	23	cancer	cancer	NOUN
gs-4060	682	24	as	as	ADP
gs-4060	682	25	a	a	DET
gs-4060	682	26	chronic	chronic	ADJ
gs-4060	682	27	disease	disease	NOUN
gs-4060	682	28	by	by	ADP
gs-4060	682	29	understanding	understand	VERB
gs-4060	682	30	and	and	CCONJ
gs-4060	682	31	manipulating	manipulate	VERB
gs-4060	682	32	the	the	DET
gs-4060	682	33	evolutionary	evolutionary	ADJ
gs-4060	682	34	dynamics	dynamic	NOUN
gs-4060	682	35	within	within	ADP
gs-4060	682	36	the	the	DET
gs-4060	682	37	tumor	tumor	NOUN
gs-4060	682	38	ecosystem	ecosystem	NOUN
gs-4060	682	39	.	.	PUNCT
gs-4060	683	1	this	this	DET
gs-4060	683	2	deeper	deep	ADJ
gs-4060	683	3	dive	dive	NOUN
gs-4060	683	4	into	into	ADP
gs-4060	683	5	atomic	atomic	ADJ
gs-4060	683	6	-	-	PUNCT
gs-4060	683	7	level	level	NOUN
gs-4060	683	8	design	design	NOUN
gs-4060	683	9	,	,	PUNCT
gs-4060	683	10	epigenetic	epigenetic	ADJ
gs-4060	683	11	regulation	regulation	NOUN
gs-4060	683	12	,	,	PUNCT
gs-4060	683	13	spatial	spatial	ADJ
gs-4060	683	14	context	context	NOUN
gs-4060	683	15	,	,	PUNCT
gs-4060	683	16	and	and	CCONJ
gs-4060	683	17	evolving	evolve	VERB
gs-4060	683	18	treatment	treatment	NOUN
gs-4060	683	19	philosophies	philosophy	NOUN
gs-4060	683	20	illustrates	illustrate	VERB
gs-4060	683	21	that	that	SCONJ
gs-4060	683	22	the	the	DET
gs-4060	683	23	science	science	NOUN
gs-4060	683	24	of	of	ADP
gs-4060	683	25	new	new	ADJ
gs-4060	683	26	anticancer	anticancer	NOUN
gs-4060	683	27	drugs	drug	NOUN
gs-4060	683	28	is	be	AUX
gs-4060	683	29	moving	move	VERB
gs-4060	683	30	beyond	beyond	ADP
gs-4060	683	31	a	a	DET
gs-4060	683	32	simple	simple	ADJ
gs-4060	683	33	"	"	PUNCT
gs-4060	683	34	one	one	NUM
gs-4060	683	35	drug	drug	NOUN
gs-4060	683	36	,	,	PUNCT
gs-4060	683	37	one	one	NUM
gs-4060	683	38	target	target	NOUN
gs-4060	683	39	"	"	PUNCT
gs-4060	683	40	model	model	NOUN
gs-4060	683	41	.	.	PUNCT
gs-4060	684	1	it	it	PRON
gs-4060	684	2	is	be	AUX
gs-4060	684	3	evolving	evolve	VERB
gs-4060	684	4	into	into	ADP
gs-4060	684	5	a	a	DET
gs-4060	684	6	complex	complex	ADJ
gs-4060	684	7	,	,	PUNCT
gs-4060	684	8	integrative	integrative	ADJ
gs-4060	684	9	discipline	discipline	NOUN
gs-4060	684	10	that	that	PRON
gs-4060	684	11	requires	require	VERB
gs-4060	684	12	synthesizing	synthesize	VERB
gs-4060	684	13	information	information	NOUN
gs-4060	684	14	from	from	ADP
gs-4060	684	15	structural	structural	ADJ
gs-4060	684	16	biology	biology	NOUN
gs-4060	684	17	,	,	PUNCT
gs-4060	684	18	biochemistry	biochemistry	NOUN
gs-4060	684	19	,	,	PUNCT
gs-4060	684	20	cellular	cellular	ADJ
gs-4060	684	21	ecology	ecology	NOUN
gs-4060	684	22	,	,	PUNCT
gs-4060	684	23	and	and	CCONJ
gs-4060	684	24	evolutionary	evolutionary	ADJ
gs-4060	684	25	theory	theory	NOUN
gs-4060	684	26	to	to	PART
gs-4060	684	27	outmaneuver	outmaneuver	VERB
gs-4060	684	28	one	one	NUM
gs-4060	684	29	of	of	ADP
gs-4060	684	30	the	the	DET
gs-4060	684	31	most	most	ADV
gs-4060	684	32	adaptive	adaptive	ADJ
gs-4060	684	33	adversaries	adversary	NOUN
gs-4060	684	34	in	in	ADP
gs-4060	684	35	medicine	medicine	NOUN
gs-4060	684	36	.	.	PUNCT
gs-4060	685	1	conclusions	conclusion	NOUN
gs-4060	685	2	the	the	DET
gs-4060	685	3	development	development	NOUN
gs-4060	685	4	and	and	CCONJ
gs-4060	685	5	integration	integration	NOUN
gs-4060	685	6	of	of	ADP
gs-4060	685	7	new	new	ADJ
gs-4060	685	8	anticancer	anticancer	NOUN
gs-4060	685	9	drugs	drug	NOUN
gs-4060	685	10	represent	represent	VERB
gs-4060	685	11	a	a	DET
gs-4060	685	12	paradigm	paradigm	NOUN
gs-4060	685	13	shift	shift	NOUN
gs-4060	685	14	in	in	ADP
gs-4060	685	15	oncology	oncology	NOUN
gs-4060	685	16	,	,	PUNCT
gs-4060	685	17	moving	move	VERB
gs-4060	685	18	the	the	DET
gs-4060	685	19	field	field	NOUN
gs-4060	685	20	decisively	decisively	ADV
gs-4060	685	21	from	from	ADP
gs-4060	685	22	a	a	DET
gs-4060	685	23	one	one	NUM
gs-4060	685	24	-	-	PUNCT
gs-4060	685	25	size	size	NOUN
gs-4060	685	26	-	-	PUNCT
gs-4060	685	27	fits	fit	VERB
gs-4060	685	28	-	-	PUNCT
gs-4060	685	29	all	all	PRON
gs-4060	685	30	approach	approach	NOUN
gs-4060	685	31	rooted	root	VERB
gs-4060	685	32	in	in	ADP
gs-4060	685	33	nonspecific	nonspecific	ADJ
gs-4060	685	34	cytotoxicity	cytotoxicity	NOUN
gs-4060	685	35	to	to	ADP
gs-4060	685	36	a	a	DET
gs-4060	685	37	sophisticated	sophisticated	ADJ
gs-4060	685	38	discipline	discipline	NOUN
gs-4060	685	39	of	of	ADP
gs-4060	685	40	precision	precision	NOUN
gs-4060	685	41	medicine	medicine	NOUN
gs-4060	685	42	.	.	PUNCT
gs-4060	686	1	this	this	DET
gs-4060	686	2	transition	transition	NOUN
gs-4060	686	3	,	,	PUNCT
gs-4060	686	4	fueled	fuel	VERB
gs-4060	686	5	by	by	ADP
gs-4060	686	6	monumental	monumental	ADJ
gs-4060	686	7	advances	advance	NOUN
gs-4060	686	8	in	in	ADP
gs-4060	686	9	our	our	PRON
gs-4060	686	10	understanding	understanding	NOUN
gs-4060	686	11	of	of	ADP
gs-4060	686	12	cancer	cancer	NOUN
gs-4060	686	13	biology	biology	NOUN
gs-4060	686	14	,	,	PUNCT
gs-4060	686	15	genomics	genomics	NOUN
gs-4060	686	16	,	,	PUNCT
gs-4060	686	17	and	and	CCONJ
gs-4060	686	18	immunology	immunology	NOUN
gs-4060	686	19	,	,	PUNCT
gs-4060	686	20	has	have	AUX
gs-4060	686	21	fundamentally	fundamentally	ADV
gs-4060	686	22	altered	alter	VERB
gs-4060	686	23	the	the	DET
gs-4060	686	24	therapeutic	therapeutic	ADJ
gs-4060	686	25	landscape	landscape	NOUN
gs-4060	686	26	and	and	CCONJ
gs-4060	686	27	patient	patient	ADJ
gs-4060	686	28	outcomes	outcome	NOUN
gs-4060	686	29	across	across	ADP
gs-4060	686	30	a	a	DET
gs-4060	686	31	wide	wide	ADJ
gs-4060	686	32	spectrum	spectrum	NOUN
gs-4060	686	33	of	of	ADP
gs-4060	686	34	malignancies	malignancy	NOUN
gs-4060	686	35	.	.	PUNCT
gs-4060	687	1	the	the	DET
gs-4060	687	2	modern	modern	ADJ
gs-4060	687	3	classification	classification	NOUN
gs-4060	687	4	of	of	ADP
gs-4060	687	5	these	these	DET
gs-4060	687	6	agents	agent	NOUN
gs-4060	687	7	—	—	PUNCT
gs-4060	687	8	categorizing	categorize	VERB
gs-4060	687	9	them	they	PRON
gs-4060	687	10	by	by	ADP
gs-4060	687	11	their	their	PRON
gs-4060	687	12	mechanism	mechanism	NOUN
gs-4060	687	13	of	of	ADP
gs-4060	687	14	action	action	NOUN
gs-4060	687	15	into	into	ADP
gs-4060	687	16	targeted	target	VERB
gs-4060	687	17	therapies	therapy	NOUN
gs-4060	687	18	and	and	CCONJ
gs-4060	687	19	immunotherapies	immunotherapy	NOUN
gs-4060	687	20	—	—	PUNCT
gs-4060	687	21	provides	provide	VERB
gs-4060	687	22	a	a	DET
gs-4060	687	23	necessary	necessary	ADJ
gs-4060	687	24	framework	framework	NOUN
gs-4060	687	25	for	for	ADP
gs-4060	687	26	georgian	georgian	NOUN
gs-4060	687	27	scientists/	scientists/	NUM
gs-4060	687	28	.	.	PUNCT
gs-4060	688	1	7	7	NUM
gs-4060	688	2	n	n	PRON
gs-4060	688	3	3	3	NUM
gs-4060	688	4	,	,	PUNCT
gs-4060	688	5	2025	2025	NUM
gs-4060	688	6	601	601	NUM
gs-4060	688	7	understanding	understand	VERB
gs-4060	688	8	their	their	PRON
gs-4060	688	9	distinct	distinct	ADJ
gs-4060	688	10	scientific	scientific	ADJ
gs-4060	688	11	and	and	CCONJ
gs-4060	688	12	clinical	clinical	ADJ
gs-4060	688	13	profiles	profile	NOUN
gs-4060	688	14	.	.	PUNCT
gs-4060	689	1	targeted	target	VERB
gs-4060	689	2	therapies	therapy	NOUN
gs-4060	689	3	,	,	PUNCT
gs-4060	689	4	including	include	VERB
gs-4060	689	5	small	small	ADJ
gs-4060	689	6	molecule	molecule	NOUN
gs-4060	689	7	inhibitors	inhibitor	NOUN
gs-4060	689	8	and	and	CCONJ
gs-4060	689	9	monoclonal	monoclonal	NOUN
gs-4060	689	10	antibodies	antibody	NOUN
gs-4060	689	11	,	,	PUNCT
gs-4060	689	12	exemplify	exemplify	VERB
gs-4060	689	13	the	the	DET
gs-4060	689	14	principle	principle	NOUN
gs-4060	689	15	of	of	ADP
gs-4060	689	16	rational	rational	ADJ
gs-4060	689	17	drug	drug	NOUN
gs-4060	689	18	design	design	NOUN
gs-4060	689	19	,	,	PUNCT
gs-4060	689	20	interfering	interfere	VERB
gs-4060	689	21	with	with	ADP
gs-4060	689	22	specific	specific	ADJ
gs-4060	689	23	molecular	molecular	ADJ
gs-4060	689	24	drivers	driver	NOUN
gs-4060	689	25	essential	essential	ADJ
gs-4060	689	26	for	for	ADP
gs-4060	689	27	tumor	tumor	NOUN
gs-4060	689	28	survival	survival	NOUN
gs-4060	689	29	and	and	CCONJ
gs-4060	689	30	proliferation	proliferation	NOUN
gs-4060	689	31	.	.	PUNCT
gs-4060	690	1	immunotherapies	immunotherapy	NOUN
gs-4060	690	2	,	,	PUNCT
gs-4060	690	3	particularly	particularly	ADV
gs-4060	690	4	immune	immune	ADJ
gs-4060	690	5	checkpoint	checkpoint	NOUN
gs-4060	690	6	inhibitors	inhibitor	NOUN
gs-4060	690	7	and	and	CCONJ
gs-4060	690	8	car	car	NOUN
gs-4060	690	9	t	t	NOUN
gs-4060	690	10	-	-	PUNCT
gs-4060	690	11	cell	cell	NOUN
gs-4060	690	12	therapies	therapy	NOUN
gs-4060	690	13	,	,	PUNCT
gs-4060	690	14	represent	represent	VERB
gs-4060	690	15	a	a	DET
gs-4060	690	16	conceptual	conceptual	ADJ
gs-4060	690	17	revolution	revolution	NOUN
gs-4060	690	18	,	,	PUNCT
gs-4060	690	19	harnessing	harness	VERB
gs-4060	690	20	the	the	DET
gs-4060	690	21	formidable	formidable	ADJ
gs-4060	690	22	power	power	NOUN
gs-4060	690	23	of	of	ADP
gs-4060	690	24	the	the	DET
gs-4060	690	25	patient	patient	NOUN
gs-4060	690	26	's	's	PART
gs-4060	690	27	own	own	ADJ
gs-4060	690	28	immune	immune	ADJ
gs-4060	690	29	system	system	NOUN
gs-4060	690	30	to	to	PART
gs-4060	690	31	achieve	achieve	VERB
gs-4060	690	32	durable	durable	ADJ
gs-4060	690	33	,	,	PUNCT
gs-4060	690	34	and	and	CCONJ
gs-4060	690	35	sometimes	sometimes	ADV
gs-4060	690	36	curative	curative	ADJ
gs-4060	690	37	,	,	PUNCT
gs-4060	690	38	responses	response	NOUN
gs-4060	690	39	in	in	ADP
gs-4060	690	40	previously	previously	ADV
gs-4060	690	41	intractable	intractable	ADJ
gs-4060	690	42	cancers	cancer	NOUN
gs-4060	690	43	.	.	PUNCT
gs-4060	691	1	the	the	DET
gs-4060	691	2	efficacy	efficacy	NOUN
gs-4060	691	3	of	of	ADP
gs-4060	691	4	these	these	DET
gs-4060	691	5	novel	novel	ADJ
gs-4060	691	6	modalities	modality	NOUN
gs-4060	691	7	is	be	AUX
gs-4060	691	8	inextricably	inextricably	ADV
gs-4060	691	9	linked	link	VERB
gs-4060	691	10	to	to	ADP
gs-4060	691	11	the	the	DET
gs-4060	691	12	identification	identification	NOUN
gs-4060	691	13	of	of	ADP
gs-4060	691	14	predictive	predictive	ADJ
gs-4060	691	15	biomarkers	biomarker	NOUN
gs-4060	691	16	,	,	PUNCT
gs-4060	691	17	cementing	cement	VERB
gs-4060	691	18	comprehensive	comprehensive	ADJ
gs-4060	691	19	molecular	molecular	ADJ
gs-4060	691	20	profiling	profiling	NOUN
gs-4060	691	21	as	as	ADP
gs-4060	691	22	a	a	DET
gs-4060	691	23	standard	standard	NOUN
gs-4060	691	24	of	of	ADP
gs-4060	691	25	care	care	NOUN
gs-4060	691	26	.	.	PUNCT
gs-4060	692	1	this	this	DET
gs-4060	692	2	biomarker	biomarker	NOUN
gs-4060	692	3	-	-	PUNCT
gs-4060	692	4	driven	drive	VERB
gs-4060	692	5	strategy	strategy	NOUN
gs-4060	692	6	ensures	ensure	VERB
gs-4060	692	7	that	that	SCONJ
gs-4060	692	8	the	the	DET
gs-4060	692	9	right	right	ADJ
gs-4060	692	10	drug	drug	NOUN
gs-4060	692	11	is	be	AUX
gs-4060	692	12	matched	match	VERB
gs-4060	692	13	to	to	ADP
gs-4060	692	14	the	the	DET
gs-4060	692	15	right	right	ADJ
gs-4060	692	16	patient	patient	NOUN
gs-4060	692	17	,	,	PUNCT
gs-4060	692	18	maximizing	maximize	VERB
gs-4060	692	19	therapeutic	therapeutic	ADJ
gs-4060	692	20	benefit	benefit	NOUN
gs-4060	692	21	while	while	SCONJ
gs-4060	692	22	minimizing	minimize	VERB
gs-4060	692	23	exposure	exposure	NOUN
gs-4060	692	24	to	to	ADP
gs-4060	692	25	ineffective	ineffective	ADJ
gs-4060	692	26	treatments	treatment	NOUN
gs-4060	692	27	and	and	CCONJ
gs-4060	692	28	their	their	PRON
gs-4060	692	29	associated	associated	ADJ
gs-4060	692	30	toxicities	toxicity	NOUN
gs-4060	692	31	.	.	PUNCT
gs-4060	693	1	however	however	ADV
gs-4060	693	2	,	,	PUNCT
gs-4060	693	3	the	the	DET
gs-4060	693	4	clinical	clinical	ADJ
gs-4060	693	5	application	application	NOUN
gs-4060	693	6	of	of	ADP
gs-4060	693	7	these	these	DET
gs-4060	693	8	drugs	drug	NOUN
gs-4060	693	9	is	be	AUX
gs-4060	693	10	tempered	temper	VERB
gs-4060	693	11	by	by	ADP
gs-4060	693	12	their	their	PRON
gs-4060	693	13	unique	unique	ADJ
gs-4060	693	14	and	and	CCONJ
gs-4060	693	15	often	often	ADV
gs-4060	693	16	formidable	formidable	ADJ
gs-4060	693	17	challenge	challenge	NOUN
gs-4060	693	18	of	of	ADP
gs-4060	693	19	resistance	resistance	NOUN
gs-4060	693	20	.	.	PUNCT
gs-4060	694	1	the	the	DET
gs-4060	694	2	remarkable	remarkable	ADJ
gs-4060	694	3	adaptability	adaptability	NOUN
gs-4060	694	4	of	of	ADP
gs-4060	694	5	cancer	cancer	NOUN
gs-4060	694	6	cells	cell	NOUN
gs-4060	694	7	,	,	PUNCT
gs-4060	694	8	through	through	ADP
gs-4060	694	9	on	on	ADP
gs-4060	694	10	-	-	PUNCT
gs-4060	694	11	target	target	NOUN
gs-4060	694	12	mutations	mutation	NOUN
gs-4060	694	13	,	,	PUNCT
gs-4060	694	14	activation	activation	NOUN
gs-4060	694	15	of	of	ADP
gs-4060	694	16	bypass	bypass	NOUN
gs-4060	694	17	pathways	pathway	NOUN
gs-4060	694	18	,	,	PUNCT
gs-4060	694	19	and	and	CCONJ
gs-4060	694	20	phenotypic	phenotypic	ADJ
gs-4060	694	21	plasticity	plasticity	NOUN
gs-4060	694	22	,	,	PUNCT
gs-4060	694	23	necessitates	necessitate	VERB
gs-4060	694	24	a	a	DET
gs-4060	694	25	continuous	continuous	ADJ
gs-4060	694	26	cycle	cycle	NOUN
gs-4060	694	27	of	of	ADP
gs-4060	694	28	research	research	NOUN
gs-4060	694	29	,	,	PUNCT
gs-4060	694	30	drug	drug	NOUN
gs-4060	694	31	discovery	discovery	NOUN
gs-4060	694	32	,	,	PUNCT
gs-4060	694	33	and	and	CCONJ
gs-4060	694	34	the	the	DET
gs-4060	694	35	development	development	NOUN
gs-4060	694	36	of	of	ADP
gs-4060	694	37	rational	rational	ADJ
gs-4060	694	38	combination	combination	NOUN
gs-4060	694	39	strategies	strategy	NOUN
gs-4060	694	40	.	.	PUNCT
gs-4060	695	1	furthermore	furthermore	ADV
gs-4060	695	2	,	,	PUNCT
gs-4060	695	3	the	the	DET
gs-4060	695	4	toxicity	toxicity	NOUN
gs-4060	695	5	profiles	profile	NOUN
gs-4060	695	6	of	of	ADP
gs-4060	695	7	these	these	DET
gs-4060	695	8	agents	agent	NOUN
gs-4060	695	9	are	be	AUX
gs-4060	695	10	distinct	distinct	ADJ
gs-4060	695	11	from	from	ADP
gs-4060	695	12	traditional	traditional	ADJ
gs-4060	695	13	chemotherapy	chemotherapy	NOUN
gs-4060	695	14	.	.	PUNCT
gs-4060	696	1	targeted	target	VERB
gs-4060	696	2	agents	agent	NOUN
gs-4060	696	3	cause	cause	VERB
gs-4060	696	4	mechanism	mechanism	NOUN
gs-4060	696	5	-	-	PUNCT
gs-4060	696	6	based	base	VERB
gs-4060	696	7	"	"	PUNCT
gs-4060	696	8	on	on	ADP
gs-4060	696	9	-	-	PUNCT
gs-4060	696	10	target	target	NOUN
gs-4060	696	11	"	"	PUNCT
gs-4060	696	12	toxicities	toxicity	NOUN
gs-4060	696	13	in	in	ADP
gs-4060	696	14	healthy	healthy	ADJ
gs-4060	696	15	tissues	tissue	NOUN
gs-4060	696	16	,	,	PUNCT
gs-4060	696	17	while	while	SCONJ
gs-4060	696	18	immunotherapies	immunotherapy	NOUN
gs-4060	696	19	can	can	AUX
gs-4060	696	20	unleash	unleash	VERB
gs-4060	696	21	a	a	DET
gs-4060	696	22	spectrum	spectrum	NOUN
gs-4060	696	23	of	of	ADP
gs-4060	696	24	immune	immune	NOUN
gs-4060	696	25	-	-	PUNCT
gs-4060	696	26	related	relate	VERB
gs-4060	696	27	adverse	adverse	ADJ
gs-4060	696	28	events	event	NOUN
gs-4060	696	29	affecting	affect	VERB
gs-4060	696	30	any	any	DET
gs-4060	696	31	organ	organ	NOUN
gs-4060	696	32	system	system	NOUN
gs-4060	696	33	.	.	PUNCT
gs-4060	697	1	the	the	DET
gs-4060	697	2	management	management	NOUN
gs-4060	697	3	of	of	ADP
gs-4060	697	4	these	these	DET
gs-4060	697	5	toxicities	toxicity	NOUN
gs-4060	697	6	requires	require	VERB
gs-4060	697	7	vigilant	vigilant	ADJ
gs-4060	697	8	monitoring	monitoring	NOUN
gs-4060	697	9	,	,	PUNCT
gs-4060	697	10	prompt	prompt	ADJ
gs-4060	697	11	recognition	recognition	NOUN
gs-4060	697	12	,	,	PUNCT
gs-4060	697	13	and	and	CCONJ
gs-4060	697	14	specialized	specialized	ADJ
gs-4060	697	15	interventions	intervention	NOUN
gs-4060	697	16	,	,	PUNCT
gs-4060	697	17	underscoring	underscore	VERB
gs-4060	697	18	the	the	DET
gs-4060	697	19	need	need	NOUN
gs-4060	697	20	for	for	ADP
gs-4060	697	21	a	a	DET
gs-4060	697	22	multidisciplinary	multidisciplinary	ADJ
gs-4060	697	23	approach	approach	NOUN
gs-4060	697	24	to	to	ADP
gs-4060	697	25	patient	patient	ADJ
gs-4060	697	26	care	care	NOUN
gs-4060	697	27	.	.	PUNCT
gs-4060	698	1	looking	look	VERB
gs-4060	698	2	forward	forward	ADV
gs-4060	698	3	,	,	PUNCT
gs-4060	698	4	the	the	DET
gs-4060	698	5	future	future	NOUN
gs-4060	698	6	of	of	ADP
gs-4060	698	7	oncology	oncology	NOUN
gs-4060	698	8	lies	lie	VERB
gs-4060	698	9	in	in	ADP
gs-4060	698	10	the	the	DET
gs-4060	698	11	continued	continue	VERB
gs-4060	698	12	deepening	deepening	NOUN
gs-4060	698	13	of	of	ADP
gs-4060	698	14	our	our	PRON
gs-4060	698	15	understanding	understanding	NOUN
gs-4060	698	16	of	of	ADP
gs-4060	698	17	the	the	DET
gs-4060	698	18	tumor	tumor	NOUN
gs-4060	698	19	ecosystem	ecosystem	NOUN
gs-4060	698	20	.	.	PUNCT
gs-4060	699	1	this	this	PRON
gs-4060	699	2	includes	include	VERB
gs-4060	699	3	deciphering	decipher	VERB
gs-4060	699	4	the	the	DET
gs-4060	699	5	complex	complex	ADJ
gs-4060	699	6	role	role	NOUN
gs-4060	699	7	of	of	ADP
gs-4060	699	8	the	the	DET
gs-4060	699	9	tumor	tumor	NOUN
gs-4060	699	10	microenvironment	microenvironment	NOUN
gs-4060	699	11	,	,	PUNCT
gs-4060	699	12	overcoming	overcome	VERB
gs-4060	699	13	adaptive	adaptive	ADJ
gs-4060	699	14	resistance	resistance	NOUN
gs-4060	699	15	through	through	ADP
gs-4060	699	16	evolutionary	evolutionary	ADJ
gs-4060	699	17	-	-	PUNCT
gs-4060	699	18	informed	inform	VERB
gs-4060	699	19	therapeutic	therapeutic	ADJ
gs-4060	699	20	strategies	strategy	NOUN
gs-4060	699	21	,	,	PUNCT
gs-4060	699	22	and	and	CCONJ
gs-4060	699	23	leveraging	leverage	VERB
gs-4060	699	24	emerging	emerge	VERB
gs-4060	699	25	technologies	technology	NOUN
gs-4060	699	26	such	such	ADJ
gs-4060	699	27	as	as	ADP
gs-4060	699	28	artificial	artificial	ADJ
gs-4060	699	29	intelligence	intelligence	NOUN
gs-4060	699	30	for	for	ADP
gs-4060	699	31	drug	drug	NOUN
gs-4060	699	32	discovery	discovery	NOUN
gs-4060	699	33	and	and	CCONJ
gs-4060	699	34	biomarker	biomarker	NOUN
gs-4060	699	35	identification	identification	NOUN
gs-4060	699	36	.	.	PUNCT
gs-4060	700	1	the	the	DET
gs-4060	700	2	exploration	exploration	NOUN
gs-4060	700	3	of	of	ADP
gs-4060	700	4	novel	novel	ADJ
gs-4060	700	5	platforms	platform	NOUN
gs-4060	700	6	like	like	ADP
gs-4060	700	7	protacs	protac	NOUN
gs-4060	700	8	,	,	PUNCT
gs-4060	700	9	radioligand	radioligand	NOUN
gs-4060	700	10	therapies	therapy	NOUN
gs-4060	700	11	,	,	PUNCT
gs-4060	700	12	and	and	CCONJ
gs-4060	700	13	personalized	personalized	ADJ
gs-4060	700	14	cancer	cancer	NOUN
gs-4060	700	15	vaccines	vaccine	NOUN
gs-4060	700	16	promises	promise	VERB
gs-4060	700	17	to	to	PART
gs-4060	700	18	further	far	ADV
gs-4060	700	19	expand	expand	VERB
gs-4060	700	20	our	our	PRON
gs-4060	700	21	therapeutic	therapeutic	ADJ
gs-4060	700	22	arsenal	arsenal	NOUN
gs-4060	700	23	.	.	PUNCT
gs-4060	701	1	however	however	ADV
gs-4060	701	2	,	,	PUNCT
gs-4060	701	3	the	the	DET
gs-4060	701	4	scientific	scientific	ADJ
gs-4060	701	5	and	and	CCONJ
gs-4060	701	6	clinical	clinical	ADJ
gs-4060	701	7	success	success	NOUN
gs-4060	701	8	of	of	ADP
gs-4060	701	9	these	these	DET
gs-4060	701	10	advances	advance	NOUN
gs-4060	701	11	must	must	AUX
gs-4060	701	12	be	be	AUX
gs-4060	701	13	coupled	couple	VERB
gs-4060	701	14	with	with	ADP
gs-4060	701	15	a	a	DET
gs-4060	701	16	concerted	concerted	ADJ
gs-4060	701	17	effort	effort	NOUN
gs-4060	701	18	to	to	PART
gs-4060	701	19	address	address	VERB
gs-4060	701	20	the	the	DET
gs-4060	701	21	significant	significant	ADJ
gs-4060	701	22	challenges	challenge	NOUN
gs-4060	701	23	of	of	ADP
gs-4060	701	24	financial	financial	ADJ
gs-4060	701	25	toxicity	toxicity	NOUN
gs-4060	701	26	and	and	CCONJ
gs-4060	701	27	equitable	equitable	ADJ
gs-4060	701	28	global	global	ADJ
gs-4060	701	29	access	access	NOUN
gs-4060	701	30	.	.	PUNCT
gs-4060	702	1	in	in	ADP
gs-4060	702	2	conclusion	conclusion	NOUN
gs-4060	702	3	,	,	PUNCT
gs-4060	702	4	the	the	DET
gs-4060	702	5	scientific	scientific	ADJ
gs-4060	702	6	aspects	aspect	NOUN
gs-4060	702	7	of	of	ADP
gs-4060	702	8	new	new	ADJ
gs-4060	702	9	anticancer	anticancer	NOUN
gs-4060	702	10	drugs	drug	NOUN
gs-4060	702	11	—	—	PUNCT
gs-4060	702	12	encompassing	encompass	VERB
gs-4060	702	13	their	their	PRON
gs-4060	702	14	classification	classification	NOUN
gs-4060	702	15	,	,	PUNCT
gs-4060	702	16	mechanisms	mechanism	NOUN
gs-4060	702	17	,	,	PUNCT
gs-4060	702	18	pharmacology	pharmacology	NOUN
gs-4060	702	19	,	,	PUNCT
gs-4060	702	20	clinical	clinical	ADJ
gs-4060	702	21	use	use	NOUN
gs-4060	702	22	,	,	PUNCT
gs-4060	702	23	and	and	CCONJ
gs-4060	702	24	toxicities	toxicity	NOUN
gs-4060	702	25	—	—	PUNCT
gs-4060	702	26	paint	paint	VERB
gs-4060	702	27	a	a	DET
gs-4060	702	28	picture	picture	NOUN
gs-4060	702	29	of	of	ADP
gs-4060	702	30	a	a	DET
gs-4060	702	31	dynamic	dynamic	ADJ
gs-4060	702	32	and	and	CCONJ
gs-4060	702	33	rapidly	rapidly	ADV
gs-4060	702	34	evolving	evolve	VERB
gs-4060	702	35	field	field	NOUN
gs-4060	702	36	.	.	PUNCT
gs-4060	703	1	the	the	DET
gs-4060	703	2	journey	journey	NOUN
gs-4060	703	3	from	from	ADP
gs-4060	703	4	cytotoxic	cytotoxic	ADJ
gs-4060	703	5	chemotherapy	chemotherapy	NOUN
gs-4060	703	6	to	to	ADP
gs-4060	703	7	precision	precision	NOUN
gs-4060	703	8	medicine	medicine	NOUN
gs-4060	703	9	stands	stand	VERB
gs-4060	703	10	as	as	ADP
gs-4060	703	11	one	one	NUM
gs-4060	703	12	of	of	ADP
gs-4060	703	13	the	the	DET
gs-4060	703	14	most	most	ADV
gs-4060	703	15	significant	significant	ADJ
gs-4060	703	16	achievements	achievement	NOUN
gs-4060	703	17	in	in	ADP
gs-4060	703	18	modern	modern	ADJ
gs-4060	703	19	science	science	NOUN
gs-4060	703	20	and	and	CCONJ
gs-4060	703	21	medicine	medicine	NOUN
gs-4060	703	22	.	.	PUNCT
gs-4060	704	1	by	by	ADP
gs-4060	704	2	continuing	continue	VERB
gs-4060	704	3	to	to	PART
gs-4060	704	4	translate	translate	VERB
gs-4060	704	5	deep	deep	ADJ
gs-4060	704	6	biological	biological	ADJ
gs-4060	704	7	insight	insight	NOUN
gs-4060	704	8	into	into	ADP
gs-4060	704	9	clinical	clinical	ADJ
gs-4060	704	10	innovation	innovation	NOUN
gs-4060	704	11	,	,	PUNCT
gs-4060	704	12	the	the	DET
gs-4060	704	13	oncology	oncology	NOUN
gs-4060	704	14	community	community	NOUN
gs-4060	704	15	moves	move	VERB
gs-4060	704	16	closer	close	ADV
gs-4060	704	17	to	to	ADP
gs-4060	704	18	the	the	DET
gs-4060	704	19	ultimate	ultimate	ADJ
gs-4060	704	20	goal	goal	NOUN
gs-4060	704	21	of	of	ADP
gs-4060	704	22	transforming	transform	VERB
gs-4060	704	23	cancer	cancer	NOUN
gs-4060	704	24	into	into	ADP
gs-4060	704	25	a	a	DET
gs-4060	704	26	manageable	manageable	ADJ
gs-4060	704	27	or	or	CCONJ
gs-4060	704	28	curable	curable	ADJ
gs-4060	704	29	disease	disease	NOUN
gs-4060	704	30	for	for	ADP
gs-4060	704	31	all	all	DET
gs-4060	704	32	patients	patient	NOUN
gs-4060	704	33	.	.	PUNCT
gs-4060	705	1	recommendations	recommendation	NOUN
gs-4060	705	2	based	base	VERB
gs-4060	705	3	on	on	ADP
gs-4060	705	4	the	the	DET
gs-4060	705	5	comprehensive	comprehensive	ADJ
gs-4060	705	6	review	review	NOUN
gs-4060	705	7	of	of	ADP
gs-4060	705	8	the	the	DET
gs-4060	705	9	scientific	scientific	ADJ
gs-4060	705	10	aspects	aspect	NOUN
gs-4060	705	11	,	,	PUNCT
gs-4060	705	12	clinical	clinical	ADJ
gs-4060	705	13	applications	application	NOUN
gs-4060	705	14	,	,	PUNCT
gs-4060	705	15	and	and	CCONJ
gs-4060	705	16	associated	associated	ADJ
gs-4060	705	17	challenges	challenge	NOUN
gs-4060	705	18	of	of	ADP
gs-4060	705	19	new	new	ADJ
gs-4060	705	20	anticancer	anticancer	NOUN
gs-4060	705	21	drugs	drug	NOUN
gs-4060	705	22	,	,	PUNCT
gs-4060	705	23	the	the	DET
gs-4060	705	24	following	follow	VERB
gs-4060	705	25	recommendations	recommendation	NOUN
gs-4060	705	26	are	be	AUX
gs-4060	705	27	proposed	propose	VERB
gs-4060	705	28	for	for	ADP
gs-4060	705	29	georgian	georgian	PROPN
gs-4060	705	30	scientists/	scientists/	NUM
gs-4060	705	31	.	.	PUNCT
gs-4060	706	1	7	7	NUM
gs-4060	706	2	n	n	PRON
gs-4060	706	3	3	3	NUM
gs-4060	706	4	,	,	PUNCT
gs-4060	706	5	2025	2025	NUM
gs-4060	706	6	602	602	NUM
gs-4060	706	7	researchers	researcher	NOUN
gs-4060	706	8	,	,	PUNCT
gs-4060	706	9	clinicians	clinician	NOUN
gs-4060	706	10	,	,	PUNCT
gs-4060	706	11	policymakers	policymaker	NOUN
gs-4060	706	12	,	,	PUNCT
gs-4060	706	13	and	and	CCONJ
gs-4060	706	14	the	the	DET
gs-4060	706	15	pharmaceutical	pharmaceutical	ADJ
gs-4060	706	16	industry	industry	NOUN
gs-4060	706	17	to	to	PART
gs-4060	706	18	optimize	optimize	VERB
gs-4060	706	19	the	the	DET
gs-4060	706	20	development	development	NOUN
gs-4060	706	21	,	,	PUNCT
gs-4060	706	22	delivery	delivery	NOUN
gs-4060	706	23	,	,	PUNCT
gs-4060	706	24	and	and	CCONJ
gs-4060	706	25	accessibility	accessibility	NOUN
gs-4060	706	26	of	of	ADP
gs-4060	706	27	these	these	DET
gs-4060	706	28	transformative	transformative	ADJ
gs-4060	706	29	therapies	therapy	NOUN
gs-4060	706	30	.	.	PUNCT
gs-4060	707	1	prioritize	prioritize	VERB
gs-4060	707	2	novel	novel	ADJ
gs-4060	707	3	target	target	NOUN
gs-4060	707	4	identification	identification	NOUN
gs-4060	707	5	:	:	PUNCT
gs-4060	707	6	intensify	intensify	VERB
gs-4060	707	7	efforts	effort	NOUN
gs-4060	707	8	to	to	PART
gs-4060	707	9	target	target	VERB
gs-4060	707	10	"	"	PUNCT
gs-4060	707	11	undruggable	undruggable	ADJ
gs-4060	707	12	"	"	PUNCT
gs-4060	707	13	oncoproteins	oncoprotein	NOUN
gs-4060	707	14	(	(	PUNCT
gs-4060	707	15	e.g.	e.g.	ADV
gs-4060	707	16	,	,	PUNCT
gs-4060	707	17	kras	kras	PROPN
gs-4060	707	18	,	,	PUNCT
gs-4060	707	19	myc	myc	PROPN
gs-4060	707	20	)	)	PUNCT
gs-4060	707	21	through	through	ADP
gs-4060	707	22	innovative	innovative	ADJ
gs-4060	707	23	platforms	platform	NOUN
gs-4060	707	24	such	such	ADJ
gs-4060	707	25	as	as	ADP
gs-4060	707	26	proteolysis	proteolysis	NOUN
gs-4060	707	27	-	-	PUNCT
gs-4060	707	28	targeting	target	VERB
gs-4060	707	29	chimeras	chimera	NOUN
gs-4060	707	30	(	(	PUNCT
gs-4060	707	31	protacs	protac	NOUN
gs-4060	707	32	)	)	PUNCT
gs-4060	707	33	,	,	PUNCT
gs-4060	707	34	molecular	molecular	ADJ
gs-4060	707	35	glues	glue	NOUN
gs-4060	707	36	,	,	PUNCT
gs-4060	707	37	and	and	CCONJ
gs-4060	707	38	allosteric	allosteric	ADJ
gs-4060	707	39	inhibitors	inhibitor	NOUN
gs-4060	707	40	.	.	PUNCT
gs-4060	708	1	invest	invest	VERB
gs-4060	708	2	in	in	ADP
gs-4060	708	3	understanding	understanding	NOUN
gs-4060	708	4	and	and	CCONJ
gs-4060	708	5	overcoming	overcome	VERB
gs-4060	708	6	resistance	resistance	NOUN
gs-4060	708	7	:	:	PUNCT
gs-4060	708	8	dedicate	dedicate	VERB
gs-4060	708	9	resources	resource	NOUN
gs-4060	708	10	to	to	ADP
gs-4060	708	11	elucidating	elucidate	VERB
gs-4060	708	12	the	the	DET
gs-4060	708	13	molecular	molecular	ADJ
gs-4060	708	14	mechanisms	mechanism	NOUN
gs-4060	708	15	of	of	ADP
gs-4060	708	16	both	both	CCONJ
gs-4060	708	17	innate	innate	ADJ
gs-4060	708	18	and	and	CCONJ
gs-4060	708	19	acquired	acquire	VERB
gs-4060	708	20	resistance	resistance	NOUN
gs-4060	708	21	.	.	PUNCT
gs-4060	709	1	focus	focus	VERB
gs-4060	709	2	on	on	ADP
gs-4060	709	3	non	non	ADJ
gs-4060	709	4	-	-	ADJ
gs-4060	709	5	mutational	mutational	ADJ
gs-4060	709	6	adaptive	adaptive	ADJ
gs-4060	709	7	resistance	resistance	NOUN
gs-4060	709	8	,	,	PUNCT
gs-4060	709	9	including	include	VERB
gs-4060	709	10	cellular	cellular	ADJ
gs-4060	709	11	plasticity	plasticity	NOUN
gs-4060	709	12	,	,	PUNCT
gs-4060	709	13	epigenetic	epigenetic	ADJ
gs-4060	709	14	reprogramming	reprogramming	NOUN
gs-4060	709	15	,	,	PUNCT
gs-4060	709	16	and	and	CCONJ
gs-4060	709	17	the	the	DET
gs-4060	709	18	protective	protective	ADJ
gs-4060	709	19	role	role	NOUN
gs-4060	709	20	of	of	ADP
gs-4060	709	21	the	the	DET
gs-4060	709	22	tumor	tumor	NOUN
gs-4060	709	23	microenvironment	microenvironment	NOUN
gs-4060	709	24	,	,	PUNCT
gs-4060	709	25	to	to	PART
gs-4060	709	26	inform	inform	VERB
gs-4060	709	27	the	the	DET
gs-4060	709	28	development	development	NOUN
gs-4060	709	29	of	of	ADP
gs-4060	709	30	next	next	ADJ
gs-4060	709	31	-	-	PUNCT
gs-4060	709	32	generation	generation	NOUN
gs-4060	709	33	agents	agent	NOUN
gs-4060	709	34	and	and	CCONJ
gs-4060	709	35	rational	rational	ADJ
gs-4060	709	36	combination	combination	NOUN
gs-4060	709	37	therapies	therapy	NOUN
gs-4060	709	38	.	.	PUNCT
gs-4060	710	1	accelerate	accelerate	VERB
gs-4060	710	2	immunotherapy	immunotherapy	NOUN
gs-4060	710	3	innovation	innovation	NOUN
gs-4060	710	4	:	:	PUNCT
gs-4060	710	5	develop	develop	VERB
gs-4060	710	6	next	next	ADJ
gs-4060	710	7	-	-	PUNCT
gs-4060	710	8	generation	generation	NOUN
gs-4060	710	9	cellular	cellular	ADJ
gs-4060	710	10	therapies	therapy	NOUN
gs-4060	710	11	(	(	PUNCT
gs-4060	710	12	e.g.	e.g.	ADV
gs-4060	710	13	,	,	PUNCT
gs-4060	710	14	allogeneic	allogeneic	ADJ
gs-4060	710	15	car	car	NOUN
gs-4060	710	16	-	-	PUNCT
gs-4060	710	17	t	t	PROPN
gs-4060	710	18	/	/	SYM
gs-4060	710	19	nk	nk	PROPN
gs-4060	710	20	cells	cell	NOUN
gs-4060	710	21	,	,	PUNCT
gs-4060	710	22	dual	dual	ADV
gs-4060	710	23	-	-	PUNCT
gs-4060	710	24	targeting	target	VERB
gs-4060	710	25	cars	car	NOUN
gs-4060	710	26	)	)	PUNCT
gs-4060	710	27	with	with	ADP
gs-4060	710	28	improved	improve	VERB
gs-4060	710	29	safety	safety	NOUN
gs-4060	710	30	profiles	profile	NOUN
gs-4060	710	31	and	and	CCONJ
gs-4060	710	32	efficacy	efficacy	NOUN
gs-4060	710	33	against	against	ADP
gs-4060	710	34	solid	solid	ADJ
gs-4060	710	35	tumors	tumor	NOUN
gs-4060	710	36	.	.	PUNCT
gs-4060	711	1	explore	explore	VERB
gs-4060	711	2	novel	novel	ADJ
gs-4060	711	3	immune	immune	ADJ
gs-4060	711	4	targets	target	NOUN
gs-4060	711	5	beyond	beyond	ADP
gs-4060	711	6	pd-1	pd-1	NOUN
gs-4060	711	7	/	/	SYM
gs-4060	711	8	ctla-4	ctla-4	NOUN
gs-4060	711	9	(	(	PUNCT
gs-4060	711	10	e.g.	e.g.	ADV
gs-4060	711	11	,	,	PUNCT
gs-4060	711	12	lag-3	lag-3	X
gs-4060	711	13	,	,	PUNCT
gs-4060	711	14	tigit	tigit	NOUN
gs-4060	711	15	,	,	PUNCT
gs-4060	711	16	tim-3	tim-3	ADV
gs-4060	711	17	)	)	PUNCT
gs-4060	711	18	to	to	PART
gs-4060	711	19	overcome	overcome	VERB
gs-4060	711	20	primary	primary	ADJ
gs-4060	711	21	and	and	CCONJ
gs-4060	711	22	acquired	acquire	VERB
gs-4060	711	23	resistance	resistance	NOUN
gs-4060	711	24	.	.	PUNCT
gs-4060	712	1	integrate	integrate	VERB
gs-4060	712	2	artificial	artificial	ADJ
gs-4060	712	3	intelligence	intelligence	NOUN
gs-4060	712	4	and	and	CCONJ
gs-4060	712	5	multi	multi	NOUN
gs-4060	712	6	-	-	NOUN
gs-4060	712	7	omics	omic	NOUN
gs-4060	712	8	:	:	PUNCT
gs-4060	712	9	leverage	leverage	NOUN
gs-4060	712	10	ai	ai	VERB
gs-4060	712	11	and	and	CCONJ
gs-4060	712	12	machine	machine	NOUN
gs-4060	712	13	learning	learn	VERB
gs-4060	712	14	for	for	ADP
gs-4060	712	15	drug	drug	NOUN
gs-4060	712	16	design	design	NOUN
gs-4060	712	17	,	,	PUNCT
gs-4060	712	18	prediction	prediction	NOUN
gs-4060	712	19	of	of	ADP
gs-4060	712	20	synergistic	synergistic	ADJ
gs-4060	712	21	combinations	combination	NOUN
gs-4060	712	22	,	,	PUNCT
gs-4060	712	23	and	and	CCONJ
gs-4060	712	24	analysis	analysis	NOUN
gs-4060	712	25	of	of	ADP
gs-4060	712	26	complex	complex	ADJ
gs-4060	712	27	multi	multi	ADJ
gs-4060	712	28	-	-	ADJ
gs-4060	712	29	omic	omic	ADJ
gs-4060	712	30	datasets	dataset	NOUN
gs-4060	712	31	(	(	PUNCT
gs-4060	712	32	genomic	genomic	NOUN
gs-4060	712	33	,	,	PUNCT
gs-4060	712	34	transcriptomic	transcriptomic	ADJ
gs-4060	712	35	,	,	PUNCT
gs-4060	712	36	proteomic	proteomic	NOUN
gs-4060	712	37	,	,	PUNCT
gs-4060	712	38	spatial	spatial	ADJ
gs-4060	712	39	)	)	PUNCT
gs-4060	712	40	to	to	PART
gs-4060	712	41	identify	identify	VERB
gs-4060	712	42	novel	novel	ADJ
gs-4060	712	43	biomarkers	biomarker	NOUN
gs-4060	712	44	and	and	CCONJ
gs-4060	712	45	patient	patient	ADJ
gs-4060	712	46	subpopulations	subpopulation	NOUN
gs-4060	712	47	most	most	ADV
gs-4060	712	48	likely	likely	ADJ
gs-4060	712	49	to	to	PART
gs-4060	712	50	benefit	benefit	VERB
gs-4060	712	51	from	from	ADP
gs-4060	712	52	specific	specific	ADJ
gs-4060	712	53	interventions	intervention	NOUN
gs-4060	712	54	.	.	PUNCT
gs-4060	713	1	explore	explore	VERB
gs-4060	713	2	modulation	modulation	NOUN
gs-4060	713	3	of	of	ADP
gs-4060	713	4	the	the	DET
gs-4060	713	5	tumor	tumor	NOUN
gs-4060	713	6	microenvironment	microenvironment	NOUN
gs-4060	713	7	and	and	CCONJ
gs-4060	713	8	microbiome	microbiome	NOUN
gs-4060	713	9	:	:	PUNCT
gs-4060	713	10	invest	invest	VERB
gs-4060	713	11	in	in	ADP
gs-4060	713	12	clinical	clinical	ADJ
gs-4060	713	13	research	research	NOUN
gs-4060	713	14	evaluating	evaluating	NOUN
gs-4060	713	15	strategies	strategy	NOUN
gs-4060	713	16	to	to	PART
gs-4060	713	17	reprogram	reprogram	VERB
gs-4060	713	18	the	the	DET
gs-4060	713	19	tme	tme	X
gs-4060	713	20	(	(	PUNCT
gs-4060	713	21	e.g.	e.g.	ADV
gs-4060	713	22	,	,	PUNCT
gs-4060	713	23	targeting	targeting	NOUN
gs-4060	713	24	cafs	cafs	NOUN
gs-4060	713	25	,	,	PUNCT
gs-4060	713	26	tams	tam	NOUN
gs-4060	713	27	,	,	PUNCT
gs-4060	713	28	mdscs	mdsc	NOUN
gs-4060	713	29	)	)	PUNCT
gs-4060	713	30	and	and	CCONJ
gs-4060	713	31	modulate	modulate	VERB
gs-4060	713	32	the	the	DET
gs-4060	713	33	gut	gut	NOUN
gs-4060	713	34	microbiome	microbiome	NOUN
gs-4060	713	35	to	to	PART
gs-4060	713	36	enhance	enhance	VERB
gs-4060	713	37	the	the	DET
gs-4060	713	38	efficacy	efficacy	NOUN
gs-4060	713	39	and	and	CCONJ
gs-4060	713	40	reduce	reduce	VERB
gs-4060	713	41	the	the	DET
gs-4060	713	42	toxicity	toxicity	NOUN
gs-4060	713	43	of	of	ADP
gs-4060	713	44	existing	exist	VERB
gs-4060	713	45	therapies	therapy	NOUN
gs-4060	713	46	,	,	PUNCT
gs-4060	713	47	particularly	particularly	ADV
gs-4060	713	48	immunotherapy	immunotherapy	NOUN
gs-4060	713	49	.	.	PUNCT
gs-4060	714	1	mandate	mandate	VERB
gs-4060	714	2	comprehensive	comprehensive	ADJ
gs-4060	714	3	biomarker	biomarker	NOUN
gs-4060	714	4	testing	testing	NOUN
gs-4060	714	5	:	:	PUNCT
gs-4060	714	6	establish	establish	VERB
gs-4060	714	7	comprehensive	comprehensive	ADJ
gs-4060	714	8	molecular	molecular	ADJ
gs-4060	714	9	profiling	profiling	NOUN
gs-4060	714	10	(	(	PUNCT
gs-4060	714	11	via	via	ADP
gs-4060	714	12	ngs	ng	NOUN
gs-4060	714	13	panels	panel	NOUN
gs-4060	714	14	)	)	PUNCT
gs-4060	714	15	and	and	CCONJ
gs-4060	714	16	assessment	assessment	NOUN
gs-4060	714	17	of	of	ADP
gs-4060	714	18	relevant	relevant	ADJ
gs-4060	714	19	immune	immune	ADJ
gs-4060	714	20	biomarkers	biomarker	NOUN
gs-4060	714	21	(	(	PUNCT
gs-4060	714	22	e.g.	e.g.	ADV
gs-4060	714	23	,	,	PUNCT
gs-4060	714	24	pd	pd	PROPN
gs-4060	714	25	-	-	PUNCT
gs-4060	714	26	l1	l1	PROPN
gs-4060	714	27	,	,	PUNCT
gs-4060	714	28	tmb	tmb	PROPN
gs-4060	714	29	,	,	PUNCT
gs-4060	714	30	msi	msi	PROPN
gs-4060	714	31	)	)	PUNCT
gs-4060	714	32	as	as	ADP
gs-4060	714	33	a	a	DET
gs-4060	714	34	standard	standard	NOUN
gs-4060	714	35	of	of	ADP
gs-4060	714	36	care	care	NOUN
gs-4060	714	37	for	for	ADP
gs-4060	714	38	all	all	DET
gs-4060	714	39	patients	patient	NOUN
gs-4060	714	40	with	with	ADP
gs-4060	714	41	advanced	advanced	ADJ
gs-4060	714	42	cancer	cancer	NOUN
gs-4060	714	43	to	to	PART
gs-4060	714	44	guide	guide	VERB
gs-4060	714	45	therapeutic	therapeutic	ADJ
gs-4060	714	46	decision	decision	NOUN
gs-4060	714	47	-	-	PUNCT
gs-4060	714	48	making	making	NOUN
gs-4060	714	49	.	.	PUNCT
gs-4060	715	1	adopt	adopt	VERB
gs-4060	715	2	innovative	innovative	ADJ
gs-4060	715	3	clinical	clinical	ADJ
gs-4060	715	4	trial	trial	NOUN
gs-4060	715	5	designs	design	NOUN
gs-4060	715	6	:	:	PUNCT
gs-4060	715	7	promote	promote	VERB
gs-4060	715	8	the	the	DET
gs-4060	715	9	use	use	NOUN
gs-4060	715	10	of	of	ADP
gs-4060	715	11	basket	basket	NOUN
gs-4060	715	12	,	,	PUNCT
gs-4060	715	13	umbrella	umbrella	NOUN
gs-4060	715	14	,	,	PUNCT
gs-4060	715	15	and	and	CCONJ
gs-4060	715	16	platform	platform	NOUN
gs-4060	715	17	adaptive	adaptive	ADJ
gs-4060	715	18	trial	trial	NOUN
gs-4060	715	19	designs	design	NOUN
gs-4060	715	20	to	to	PART
gs-4060	715	21	efficiently	efficiently	ADV
gs-4060	715	22	evaluate	evaluate	VERB
gs-4060	715	23	multiple	multiple	ADJ
gs-4060	715	24	targeted	target	VERB
gs-4060	715	25	and	and	CCONJ
gs-4060	715	26	immunotherapeutic	immunotherapeutic	ADJ
gs-4060	715	27	strategies	strategy	NOUN
gs-4060	715	28	simultaneously	simultaneously	ADV
gs-4060	715	29	,	,	PUNCT
gs-4060	715	30	accelerate	accelerate	VERB
gs-4060	715	31	drug	drug	NOUN
gs-4060	715	32	development	development	NOUN
gs-4060	715	33	,	,	PUNCT
gs-4060	715	34	and	and	CCONJ
gs-4060	715	35	better	well	ADJ
gs-4060	715	36	match	match	VERB
gs-4060	715	37	patients	patient	NOUN
gs-4060	715	38	to	to	ADP
gs-4060	715	39	effective	effective	ADJ
gs-4060	715	40	therapies	therapy	NOUN
gs-4060	715	41	based	base	VERB
gs-4060	715	42	on	on	ADP
gs-4060	715	43	their	their	PRON
gs-4060	715	44	tumor	tumor	NOUN
gs-4060	715	45	's	's	PART
gs-4060	715	46	biology	biology	NOUN
gs-4060	715	47	rather	rather	ADV
gs-4060	715	48	than	than	ADP
gs-4060	715	49	its	its	PRON
gs-4060	715	50	tissue	tissue	NOUN
gs-4060	715	51	of	of	ADP
gs-4060	715	52	origin	origin	NOUN
gs-4060	715	53	.	.	PUNCT
gs-4060	716	1	develop	develop	VERB
gs-4060	716	2	and	and	CCONJ
gs-4060	716	3	validate	validate	VERB
gs-4060	716	4	surrogate	surrogate	ADJ
gs-4060	716	5	endpoints	endpoint	NOUN
gs-4060	716	6	:	:	PUNCT
gs-4060	716	7	establish	establish	VERB
gs-4060	716	8	and	and	CCONJ
gs-4060	716	9	validate	validate	VERB
gs-4060	716	10	novel	novel	ADJ
gs-4060	716	11	endpoints	endpoint	NOUN
gs-4060	716	12	beyond	beyond	ADP
gs-4060	716	13	overall	overall	ADJ
gs-4060	716	14	survival	survival	NOUN
gs-4060	716	15	(	(	PUNCT
gs-4060	716	16	e.g.	e.g.	ADV
gs-4060	716	17	,	,	PUNCT
gs-4060	716	18	duration	duration	NOUN
gs-4060	716	19	of	of	ADP
gs-4060	716	20	response	response	NOUN
gs-4060	716	21	,	,	PUNCT
gs-4060	716	22	pathologic	pathologic	ADJ
gs-4060	716	23	complete	complete	ADJ
gs-4060	716	24	response	response	NOUN
gs-4060	716	25	,	,	PUNCT
gs-4060	716	26	circulating	circulate	VERB
gs-4060	716	27	tumor	tumor	NOUN
gs-4060	716	28	dna	dna	PROPN
gs-4060	716	29	clearance	clearance	NOUN
gs-4060	716	30	)	)	PUNCT
gs-4060	716	31	that	that	PRON
gs-4060	716	32	can	can	AUX
gs-4060	716	33	more	more	ADV
gs-4060	716	34	rapidly	rapidly	ADV
gs-4060	716	35	and	and	CCONJ
gs-4060	716	36	accurately	accurately	ADV
gs-4060	716	37	capture	capture	VERB
gs-4060	716	38	the	the	DET
gs-4060	716	39	clinical	clinical	ADJ
gs-4060	716	40	benefit	benefit	NOUN
gs-4060	716	41	of	of	ADP
gs-4060	716	42	novel	novel	ADJ
gs-4060	716	43	agents	agent	NOUN
gs-4060	716	44	,	,	PUNCT
gs-4060	716	45	especially	especially	ADV
gs-4060	716	46	in	in	ADP
gs-4060	716	47	the	the	DET
gs-4060	716	48	adjuvant	adjuvant	NOUN
gs-4060	716	49	and	and	CCONJ
gs-4060	716	50	neoadjuvant	neoadjuvant	ADJ
gs-4060	716	51	settings	setting	NOUN
gs-4060	716	52	.	.	PUNCT
gs-4060	717	1	implement	implement	VERB
gs-4060	717	2	proactive	proactive	ADJ
gs-4060	717	3	toxicity	toxicity	NOUN
gs-4060	717	4	management	management	NOUN
gs-4060	717	5	protocols	protocol	NOUN
gs-4060	717	6	:	:	PUNCT
gs-4060	717	7	ensure	ensure	VERB
gs-4060	717	8	all	all	DET
gs-4060	717	9	clinical	clinical	ADJ
gs-4060	717	10	staff	staff	NOUN
gs-4060	717	11	are	be	AUX
gs-4060	717	12	trained	train	VERB
gs-4060	717	13	in	in	ADP
gs-4060	717	14	the	the	DET
gs-4060	717	15	early	early	ADJ
gs-4060	717	16	recognition	recognition	NOUN
gs-4060	717	17	and	and	CCONJ
gs-4060	717	18	evidence	evidence	NOUN
gs-4060	717	19	-	-	PUNCT
gs-4060	717	20	based	base	VERB
gs-4060	717	21	management	management	NOUN
gs-4060	717	22	of	of	ADP
gs-4060	717	23	unique	unique	ADJ
gs-4060	717	24	toxicities	toxicity	NOUN
gs-4060	717	25	,	,	PUNCT
gs-4060	717	26	particularly	particularly	ADV
gs-4060	717	27	immunerelated	immunerelate	VERB
gs-4060	717	28	adverse	adverse	ADJ
gs-4060	717	29	events	event	NOUN
gs-4060	717	30	(	(	PUNCT
gs-4060	717	31	iraes	iraes	NOUN
gs-4060	717	32	)	)	PUNCT
gs-4060	717	33	and	and	CCONJ
gs-4060	717	34	cytokine	cytokine	VERB
gs-4060	717	35	release	release	NOUN
gs-4060	717	36	syndrome	syndrome	NOUN
gs-4060	717	37	(	(	PUNCT
gs-4060	717	38	crs	crs	PROPN
gs-4060	717	39	)	)	PUNCT
gs-4060	717	40	.	.	PUNCT
gs-4060	718	1	develop	develop	VERB
gs-4060	718	2	standardized	standardized	ADJ
gs-4060	718	3	institutional	institutional	ADJ
gs-4060	718	4	protocols	protocol	NOUN
gs-4060	718	5	and	and	CCONJ
gs-4060	718	6	foster	foster	ADJ
gs-4060	718	7	close	close	ADJ
gs-4060	718	8	collaboration	collaboration	NOUN
gs-4060	718	9	with	with	ADP
gs-4060	718	10	multidisciplinary	multidisciplinary	ADJ
gs-4060	718	11	teams	team	NOUN
gs-4060	718	12	including	include	VERB
gs-4060	718	13	dermatology	dermatology	NOUN
gs-4060	718	14	,	,	PUNCT
gs-4060	718	15	gastroenterology	gastroenterology	NOUN
gs-4060	718	16	,	,	PUNCT
gs-4060	718	17	endocrinology	endocrinology	NOUN
gs-4060	718	18	,	,	PUNCT
gs-4060	718	19	and	and	CCONJ
gs-4060	718	20	neurology	neurology	NOUN
gs-4060	718	21	.	.	PUNCT
gs-4060	719	1	promote	promote	VERB
gs-4060	719	2	value	value	NOUN
gs-4060	719	3	-	-	PUNCT
gs-4060	719	4	based	base	VERB
gs-4060	719	5	pricing	pricing	NOUN
gs-4060	719	6	and	and	CCONJ
gs-4060	719	7	reimbursement	reimbursement	NOUN
gs-4060	719	8	models	model	NOUN
gs-4060	719	9	:	:	PUNCT
gs-4060	719	10	transition	transition	NOUN
gs-4060	719	11	from	from	ADP
gs-4060	719	12	cost	cost	NOUN
gs-4060	719	13	-	-	PUNCT
gs-4060	719	14	based	base	VERB
gs-4060	719	15	to	to	PART
gs-4060	719	16	valuebased	valuebase	VERB
gs-4060	719	17	pricing	pricing	NOUN
gs-4060	719	18	models	model	NOUN
gs-4060	719	19	that	that	PRON
gs-4060	719	20	align	align	VERB
gs-4060	719	21	a	a	DET
gs-4060	719	22	drug	drug	NOUN
gs-4060	719	23	's	's	PART
gs-4060	719	24	price	price	NOUN
gs-4060	719	25	with	with	ADP
gs-4060	719	26	the	the	DET
gs-4060	719	27	magnitude	magnitude	NOUN
gs-4060	719	28	of	of	ADP
gs-4060	719	29	its	its	PRON
gs-4060	719	30	clinical	clinical	ADJ
gs-4060	719	31	benefit	benefit	NOUN
gs-4060	719	32	(	(	PUNCT
gs-4060	719	33	e.g.	e.g.	ADV
gs-4060	719	34	,	,	PUNCT
gs-4060	719	35	overall	overall	ADJ
gs-4060	719	36	survival	survival	NOUN
gs-4060	719	37	gain	gain	NOUN
gs-4060	719	38	,	,	PUNCT
gs-4060	719	39	quality	quality	NOUN
gs-4060	719	40	of	of	ADP
gs-4060	719	41	life	life	NOUN
gs-4060	719	42	improvement	improvement	NOUN
gs-4060	719	43	)	)	PUNCT
gs-4060	719	44	.	.	PUNCT
gs-4060	720	1	encourage	encourage	VERB
gs-4060	720	2	outcomes	outcome	NOUN
gs-4060	720	3	-	-	PUNCT
gs-4060	720	4	based	base	VERB
gs-4060	720	5	contracts	contract	NOUN
gs-4060	720	6	between	between	ADP
gs-4060	720	7	payers	payer	NOUN
gs-4060	720	8	and	and	CCONJ
gs-4060	720	9	manufacturers	manufacturer	NOUN
gs-4060	720	10	to	to	PART
gs-4060	720	11	share	share	VERB
gs-4060	720	12	risk	risk	NOUN
gs-4060	720	13	and	and	CCONJ
gs-4060	720	14	ensure	ensure	VERB
gs-4060	720	15	payment	payment	NOUN
gs-4060	720	16	reflects	reflect	VERB
gs-4060	720	17	real	real	ADJ
gs-4060	720	18	-	-	PUNCT
gs-4060	720	19	world	world	NOUN
gs-4060	720	20	effectiveness	effectiveness	NOUN
gs-4060	720	21	.	.	PUNCT
gs-4060	721	1	georgian	georgian	NOUN
gs-4060	721	2	scientists/	scientists/	NUM
gs-4060	721	3	.	.	PUNCT
gs-4060	722	1	7	7	NUM
gs-4060	722	2	n	n	PRON
gs-4060	722	3	3	3	NUM
gs-4060	722	4	,	,	PUNCT
gs-4060	722	5	2025	2025	NUM
gs-4060	722	6	603	603	NUM
gs-4060	722	7	streamline	streamline	VERB
gs-4060	722	8	regulatory	regulatory	ADJ
gs-4060	722	9	pathways	pathway	NOUN
gs-4060	722	10	for	for	ADP
gs-4060	722	11	breakthrough	breakthrough	NOUN
gs-4060	722	12	therapies	therapy	NOUN
gs-4060	722	13	:	:	PUNCT
gs-4060	722	14	maintain	maintain	VERB
gs-4060	722	15	and	and	CCONJ
gs-4060	722	16	refine	refine	VERB
gs-4060	722	17	accelerated	accelerate	VERB
gs-4060	722	18	approval	approval	NOUN
gs-4060	722	19	pathways	pathway	NOUN
gs-4060	722	20	to	to	PART
gs-4060	722	21	ensure	ensure	VERB
gs-4060	722	22	rapid	rapid	ADJ
gs-4060	722	23	access	access	NOUN
gs-4060	722	24	to	to	ADP
gs-4060	722	25	promising	promise	VERB
gs-4060	722	26	therapies	therapy	NOUN
gs-4060	722	27	while	while	SCONJ
gs-4060	722	28	strengthening	strengthen	VERB
gs-4060	722	29	requirements	requirement	NOUN
gs-4060	722	30	for	for	ADP
gs-4060	722	31	post	post	ADJ
gs-4060	722	32	-	-	ADJ
gs-4060	722	33	marketing	marketing	ADJ
gs-4060	722	34	confirmatory	confirmatory	NOUN
gs-4060	722	35	studies	study	NOUN
gs-4060	722	36	to	to	PART
gs-4060	722	37	verify	verify	VERB
gs-4060	722	38	clinical	clinical	ADJ
gs-4060	722	39	benefit	benefit	NOUN
gs-4060	722	40	and	and	CCONJ
gs-4060	722	41	ensure	ensure	VERB
gs-4060	722	42	patient	patient	ADJ
gs-4060	722	43	safety	safety	NOUN
gs-4060	722	44	.	.	PUNCT
gs-4060	723	1	incentivize	incentivize	VERB
gs-4060	723	2	global	global	ADJ
gs-4060	723	3	access	access	NOUN
gs-4060	723	4	and	and	CCONJ
gs-4060	723	5	equity	equity	NOUN
gs-4060	723	6	:	:	PUNCT
gs-4060	723	7	create	create	VERB
gs-4060	723	8	policy	policy	NOUN
gs-4060	723	9	incentives	incentive	NOUN
gs-4060	723	10	and	and	CCONJ
gs-4060	723	11	support	support	NOUN
gs-4060	723	12	mechanisms	mechanism	NOUN
gs-4060	723	13	,	,	PUNCT
gs-4060	723	14	including	include	VERB
gs-4060	723	15	tiered	tiere	VERB
gs-4060	723	16	pricing	pricing	NOUN
gs-4060	723	17	,	,	PUNCT
gs-4060	723	18	voluntary	voluntary	ADJ
gs-4060	723	19	licensing	licensing	NOUN
gs-4060	723	20	agreements	agreement	NOUN
gs-4060	723	21	,	,	PUNCT
gs-4060	723	22	and	and	CCONJ
gs-4060	723	23	technology	technology	NOUN
gs-4060	723	24	transfer	transfer	NOUN
gs-4060	723	25	programs	program	NOUN
gs-4060	723	26	,	,	PUNCT
gs-4060	723	27	to	to	PART
gs-4060	723	28	ensure	ensure	VERB
gs-4060	723	29	patients	patient	NOUN
gs-4060	723	30	in	in	ADP
gs-4060	723	31	lowand	lowand	ADJ
gs-4060	723	32	middle	middle	ADJ
gs-4060	723	33	-	-	PUNCT
gs-4060	723	34	income	income	NOUN
gs-4060	723	35	countries	country	NOUN
gs-4060	723	36	have	have	VERB
gs-4060	723	37	access	access	NOUN
gs-4060	723	38	to	to	ADP
gs-4060	723	39	essential	essential	ADJ
gs-4060	723	40	biomarker	biomarker	NOUN
gs-4060	723	41	testing	testing	NOUN
gs-4060	723	42	and	and	CCONJ
gs-4060	723	43	life	life	NOUN
gs-4060	723	44	-	-	PUNCT
gs-4060	723	45	saving	save	VERB
gs-4060	723	46	therapies	therapy	NOUN
gs-4060	723	47	.	.	PUNCT
gs-4060	724	1	support	support	VERB
gs-4060	724	2	real	real	ADJ
gs-4060	724	3	-	-	PUNCT
gs-4060	724	4	world	world	NOUN
gs-4060	724	5	evidence	evidence	NOUN
gs-4060	724	6	generation	generation	NOUN
gs-4060	724	7	:	:	PUNCT
gs-4060	724	8	develop	develop	VERB
gs-4060	724	9	robust	robust	ADJ
gs-4060	724	10	frameworks	framework	NOUN
gs-4060	724	11	for	for	ADP
gs-4060	724	12	the	the	DET
gs-4060	724	13	collection	collection	NOUN
gs-4060	724	14	and	and	CCONJ
gs-4060	724	15	regulatory	regulatory	ADJ
gs-4060	724	16	use	use	NOUN
gs-4060	724	17	of	of	ADP
gs-4060	724	18	high	high	ADJ
gs-4060	724	19	-	-	PUNCT
gs-4060	724	20	quality	quality	NOUN
gs-4060	724	21	real	real	ADJ
gs-4060	724	22	-	-	PUNCT
gs-4060	724	23	world	world	NOUN
gs-4060	724	24	data	datum	NOUN
gs-4060	724	25	to	to	PART
gs-4060	724	26	supplement	supplement	VERB
gs-4060	724	27	clinical	clinical	ADJ
gs-4060	724	28	trial	trial	NOUN
gs-4060	724	29	findings	finding	NOUN
gs-4060	724	30	,	,	PUNCT
gs-4060	724	31	particularly	particularly	ADV
gs-4060	724	32	for	for	ADP
gs-4060	724	33	understanding	understand	VERB
gs-4060	724	34	long	long	ADJ
gs-4060	724	35	-	-	PUNCT
gs-4060	724	36	term	term	NOUN
gs-4060	724	37	outcomes	outcome	NOUN
gs-4060	724	38	and	and	CCONJ
gs-4060	724	39	toxicity	toxicity	NOUN
gs-4060	724	40	management	management	NOUN
gs-4060	724	41	in	in	ADP
gs-4060	724	42	broader	broad	ADJ
gs-4060	724	43	,	,	PUNCT
gs-4060	724	44	more	more	ADV
gs-4060	724	45	diverse	diverse	ADJ
gs-4060	724	46	patient	patient	ADJ
gs-4060	724	47	populations	population	NOUN
gs-4060	724	48	.	.	PUNCT
gs-4060	725	1	enhance	enhance	VERB
gs-4060	725	2	oncologist	oncologist	ADJ
gs-4060	725	3	education	education	NOUN
gs-4060	725	4	on	on	ADP
gs-4060	725	5	novel	novel	ADJ
gs-4060	725	6	therapies	therapy	NOUN
gs-4060	725	7	:	:	PUNCT
gs-4060	725	8	integrate	integrate	VERB
gs-4060	725	9	dedicated	dedicated	ADJ
gs-4060	725	10	training	training	NOUN
gs-4060	725	11	on	on	ADP
gs-4060	725	12	the	the	DET
gs-4060	725	13	mechanisms	mechanism	NOUN
gs-4060	725	14	of	of	ADP
gs-4060	725	15	action	action	NOUN
gs-4060	725	16	,	,	PUNCT
gs-4060	725	17	pharmacology	pharmacology	NOUN
gs-4060	725	18	,	,	PUNCT
gs-4060	725	19	and	and	CCONJ
gs-4060	725	20	unique	unique	ADJ
gs-4060	725	21	toxicities	toxicity	NOUN
gs-4060	725	22	of	of	ADP
gs-4060	725	23	targeted	target	VERB
gs-4060	725	24	therapies	therapy	NOUN
gs-4060	725	25	and	and	CCONJ
gs-4060	725	26	immunotherapies	immunotherapy	NOUN
gs-4060	725	27	into	into	ADP
gs-4060	725	28	continuing	continue	VERB
gs-4060	725	29	medical	medical	ADJ
gs-4060	725	30	education	education	NOUN
gs-4060	725	31	and	and	CCONJ
gs-4060	725	32	oncology	oncology	NOUN
gs-4060	725	33	fellowship	fellowship	NOUN
gs-4060	725	34	curricula	curricula	NOUN
gs-4060	725	35	.	.	PUNCT
gs-4060	726	1	foster	foster	VERB
gs-4060	726	2	a	a	DET
gs-4060	726	3	culture	culture	NOUN
gs-4060	726	4	of	of	ADP
gs-4060	726	5	multidisciplinary	multidisciplinary	ADJ
gs-4060	726	6	care	care	NOUN
gs-4060	726	7	:	:	PUNCT
gs-4060	726	8	establish	establish	VERB
gs-4060	726	9	formal	formal	ADJ
gs-4060	726	10	tumor	tumor	NOUN
gs-4060	726	11	boards	board	NOUN
gs-4060	726	12	and	and	CCONJ
gs-4060	726	13	care	care	VERB
gs-4060	726	14	pathways	pathway	NOUN
gs-4060	726	15	that	that	PRON
gs-4060	726	16	include	include	VERB
gs-4060	726	17	not	not	PART
gs-4060	726	18	only	only	ADV
gs-4060	726	19	oncologists	oncologist	NOUN
gs-4060	726	20	but	but	CCONJ
gs-4060	726	21	also	also	ADV
gs-4060	726	22	specialized	specialized	ADJ
gs-4060	726	23	pharmacists	pharmacist	NOUN
gs-4060	726	24	,	,	PUNCT
gs-4060	726	25	palliative	palliative	ADJ
gs-4060	726	26	care	care	NOUN
gs-4060	726	27	specialists	specialist	NOUN
gs-4060	726	28	,	,	PUNCT
gs-4060	726	29	and	and	CCONJ
gs-4060	726	30	other	other	ADJ
gs-4060	726	31	medical	medical	ADJ
gs-4060	726	32	subspecialists	subspecialist	NOUN
gs-4060	726	33	essential	essential	ADJ
gs-4060	726	34	for	for	ADP
gs-4060	726	35	managing	manage	VERB
gs-4060	726	36	complex	complex	ADJ
gs-4060	726	37	toxicities	toxicity	NOUN
gs-4060	726	38	and	and	CCONJ
gs-4060	726	39	supporting	support	VERB
gs-4060	726	40	patients	patient	NOUN
gs-4060	726	41	throughout	throughout	ADP
gs-4060	726	42	their	their	PRON
gs-4060	726	43	treatment	treatment	NOUN
gs-4060	726	44	journey	journey	NOUN
gs-4060	726	45	.	.	PUNCT
gs-4060	727	1	improve	improve	VERB
gs-4060	727	2	patient	patient	ADJ
gs-4060	727	3	education	education	NOUN
gs-4060	727	4	and	and	CCONJ
gs-4060	727	5	shared	share	VERB
gs-4060	727	6	decision	decision	NOUN
gs-4060	727	7	-	-	PUNCT
gs-4060	727	8	making	making	NOUN
gs-4060	727	9	:	:	PUNCT
gs-4060	727	10	develop	develop	VERB
gs-4060	727	11	easily	easily	ADV
gs-4060	727	12	understandable	understandable	ADJ
gs-4060	727	13	patient	patient	ADJ
gs-4060	727	14	education	education	NOUN
gs-4060	727	15	materials	material	NOUN
gs-4060	727	16	that	that	PRON
gs-4060	727	17	clearly	clearly	ADV
gs-4060	727	18	explain	explain	VERB
gs-4060	727	19	the	the	DET
gs-4060	727	20	benefits	benefit	NOUN
gs-4060	727	21	,	,	PUNCT
gs-4060	727	22	risks	risk	NOUN
gs-4060	727	23	,	,	PUNCT
gs-4060	727	24	and	and	CCONJ
gs-4060	727	25	financial	financial	ADJ
gs-4060	727	26	implications	implication	NOUN
gs-4060	727	27	of	of	ADP
gs-4060	727	28	novel	novel	ADJ
gs-4060	727	29	cancer	cancer	NOUN
gs-4060	727	30	therapies	therapy	NOUN
gs-4060	727	31	.	.	PUNCT
gs-4060	728	1	empower	empower	NOUN
gs-4060	728	2	patients	patient	NOUN
gs-4060	728	3	to	to	PART
gs-4060	728	4	participate	participate	VERB
gs-4060	728	5	actively	actively	ADV
gs-4060	728	6	in	in	ADP
gs-4060	728	7	treatment	treatment	NOUN
gs-4060	728	8	decisions	decision	NOUN
gs-4060	728	9	through	through	ADP
gs-4060	728	10	clear	clear	ADJ
gs-4060	728	11	communication	communication	NOUN
gs-4060	728	12	and	and	CCONJ
gs-4060	728	13	shared	share	VERB
gs-4060	728	14	decision	decision	NOUN
gs-4060	728	15	-	-	PUNCT
gs-4060	728	16	making	make	VERB
gs-4060	728	17	models	model	NOUN
gs-4060	728	18	.	.	PUNCT
gs-4060	729	1	implement	implement	VERB
gs-4060	729	2	universal	universal	ADJ
gs-4060	729	3	financial	financial	ADJ
gs-4060	729	4	toxicity	toxicity	NOUN
gs-4060	729	5	screening	screening	NOUN
gs-4060	729	6	:	:	PUNCT
gs-4060	729	7	routinely	routinely	ADV
gs-4060	729	8	screen	screen	NOUN
gs-4060	729	9	patients	patient	NOUN
gs-4060	729	10	for	for	ADP
gs-4060	729	11	financial	financial	ADJ
gs-4060	729	12	hardship	hardship	NOUN
gs-4060	729	13	as	as	ADP
gs-4060	729	14	a	a	DET
gs-4060	729	15	vital	vital	ADJ
gs-4060	729	16	sign	sign	NOUN
gs-4060	729	17	and	and	CCONJ
gs-4060	729	18	integrate	integrate	VERB
gs-4060	729	19	financial	financial	ADJ
gs-4060	729	20	navigators	navigator	NOUN
gs-4060	729	21	and	and	CCONJ
gs-4060	729	22	counselors	counselor	NOUN
gs-4060	729	23	into	into	ADP
gs-4060	729	24	oncology	oncology	NOUN
gs-4060	729	25	care	care	NOUN
gs-4060	729	26	teams	team	NOUN
gs-4060	729	27	to	to	PART
gs-4060	729	28	connect	connect	VERB
gs-4060	729	29	patients	patient	NOUN
gs-4060	729	30	with	with	ADP
gs-4060	729	31	resources	resource	NOUN
gs-4060	729	32	,	,	PUNCT
gs-4060	729	33	assistance	assistance	NOUN
gs-4060	729	34	programs	program	NOUN
gs-4060	729	35	,	,	PUNCT
gs-4060	729	36	and	and	CCONJ
gs-4060	729	37	support	support	NOUN
gs-4060	729	38	.	.	PUNCT
gs-4060	730	1	increase	increase	VERB
gs-4060	730	2	price	price	NOUN
gs-4060	730	3	transparency	transparency	NOUN
gs-4060	730	4	:	:	PUNCT
gs-4060	730	5	advocate	advocate	VERB
gs-4060	730	6	for	for	ADP
gs-4060	730	7	greater	great	ADJ
gs-4060	730	8	transparency	transparency	NOUN
gs-4060	730	9	in	in	ADP
gs-4060	730	10	drug	drug	NOUN
gs-4060	730	11	pricing	pricing	NOUN
gs-4060	730	12	and	and	CCONJ
gs-4060	730	13	the	the	DET
gs-4060	730	14	costs	cost	NOUN
gs-4060	730	15	associated	associate	VERB
gs-4060	730	16	with	with	ADP
gs-4060	730	17	research	research	NOUN
gs-4060	730	18	and	and	CCONJ
gs-4060	730	19	development	development	NOUN
gs-4060	730	20	to	to	PART
gs-4060	730	21	inform	inform	VERB
gs-4060	730	22	public	public	ADJ
gs-4060	730	23	discourse	discourse	NOUN
gs-4060	730	24	and	and	CCONJ
gs-4060	730	25	policy	policy	NOUN
gs-4060	730	26	decisions	decision	NOUN
gs-4060	730	27	aimed	aim	VERB
gs-4060	730	28	at	at	ADP
gs-4060	730	29	controlling	control	VERB
gs-4060	730	30	healthcare	healthcare	NOUN
gs-4060	730	31	costs	cost	NOUN
gs-4060	730	32	.	.	PUNCT
gs-4060	731	1	invest	invest	VERB
gs-4060	731	2	in	in	ADP
gs-4060	731	3	comparative	comparative	ADJ
gs-4060	731	4	effectiveness	effectiveness	NOUN
gs-4060	731	5	research	research	NOUN
gs-4060	731	6	:	:	PUNCT
gs-4060	731	7	fund	fund	NOUN
gs-4060	731	8	independent	independent	ADJ
gs-4060	731	9	research	research	NOUN
gs-4060	731	10	to	to	PART
gs-4060	731	11	compare	compare	VERB
gs-4060	731	12	the	the	DET
gs-4060	731	13	clinical	clinical	ADJ
gs-4060	731	14	and	and	CCONJ
gs-4060	731	15	cost	cost	NOUN
gs-4060	731	16	-	-	PUNCT
gs-4060	731	17	effectiveness	effectiveness	NOUN
gs-4060	731	18	of	of	ADP
gs-4060	731	19	different	different	ADJ
gs-4060	731	20	treatment	treatment	NOUN
gs-4060	731	21	sequences	sequence	NOUN
gs-4060	731	22	and	and	CCONJ
gs-4060	731	23	combinations	combination	NOUN
gs-4060	731	24	,	,	PUNCT
gs-4060	731	25	providing	provide	VERB
gs-4060	731	26	evidence	evidence	NOUN
gs-4060	731	27	to	to	PART
gs-4060	731	28	help	help	VERB
gs-4060	731	29	clinicians	clinician	NOUN
gs-4060	731	30	and	and	CCONJ
gs-4060	731	31	payers	payer	NOUN
gs-4060	731	32	make	make	VERB
gs-4060	731	33	the	the	DET
gs-4060	731	34	most	most	ADV
gs-4060	731	35	efficient	efficient	ADJ
gs-4060	731	36	use	use	NOUN
gs-4060	731	37	of	of	ADP
gs-4060	731	38	finite	finite	ADJ
gs-4060	731	39	healthcare	healthcare	PROPN
gs-4060	731	40	resources	resource	NOUN
gs-4060	731	41	.	.	PUNCT
gs-4060	732	1	by	by	ADP
gs-4060	732	2	implementing	implement	VERB
gs-4060	732	3	these	these	DET
gs-4060	732	4	multifaceted	multifaceted	ADJ
gs-4060	732	5	recommendations	recommendation	NOUN
gs-4060	732	6	,	,	PUNCT
gs-4060	732	7	the	the	DET
gs-4060	732	8	global	global	ADJ
gs-4060	732	9	oncology	oncology	NOUN
gs-4060	732	10	community	community	NOUN
gs-4060	732	11	can	can	AUX
gs-4060	732	12	build	build	VERB
gs-4060	732	13	upon	upon	SCONJ
gs-4060	732	14	the	the	DET
gs-4060	732	15	remarkable	remarkable	ADJ
gs-4060	732	16	scientific	scientific	ADJ
gs-4060	732	17	progress	progress	NOUN
gs-4060	732	18	already	already	ADV
gs-4060	732	19	achieved	achieve	VERB
gs-4060	732	20	,	,	PUNCT
gs-4060	732	21	ensuring	ensure	VERB
gs-4060	732	22	that	that	SCONJ
gs-4060	732	23	the	the	DET
gs-4060	732	24	development	development	NOUN
gs-4060	732	25	and	and	CCONJ
gs-4060	732	26	delivery	delivery	NOUN
gs-4060	732	27	of	of	ADP
gs-4060	732	28	new	new	ADJ
gs-4060	732	29	anticancer	anticancer	NOUN
gs-4060	732	30	drugs	drug	NOUN
gs-4060	732	31	are	be	AUX
gs-4060	732	32	both	both	ADV
gs-4060	732	33	innovative	innovative	ADJ
gs-4060	732	34	and	and	CCONJ
gs-4060	732	35	equitable	equitable	ADJ
gs-4060	732	36	,	,	PUNCT
gs-4060	732	37	and	and	CCONJ
gs-4060	732	38	ultimately	ultimately	ADV
gs-4060	732	39	maximizing	maximize	VERB
gs-4060	732	40	benefit	benefit	NOUN
gs-4060	732	41	for	for	ADP
gs-4060	732	42	all	all	DET
gs-4060	732	43	patients	patient	NOUN
gs-4060	732	44	.	.	PUNCT
gs-4060	733	1	references	reference	NOUN
gs-4060	733	2	1	1	NUM
gs-4060	733	3	.	.	PUNCT
gs-4060	734	1	hanahan	hanahan	PROPN
gs-4060	734	2	d	d	PROPN
gs-4060	734	3	,	,	PUNCT
gs-4060	734	4	weinberg	weinberg	PROPN
gs-4060	734	5	ra	ra	PROPN
gs-4060	734	6	.	.	PUNCT
gs-4060	735	1	hallmarks	hallmark	NOUN
gs-4060	735	2	of	of	ADP
gs-4060	735	3	cancer	cancer	NOUN
gs-4060	735	4	:	:	PUNCT
gs-4060	735	5	the	the	DET
gs-4060	735	6	next	next	ADJ
gs-4060	735	7	generation	generation	NOUN
gs-4060	735	8	.	.	PUNCT
gs-4060	736	1	cell	cell	NOUN
gs-4060	736	2	.	.	PUNCT
gs-4060	737	1	2011;144(5):646	2011;144(5):646	NUM
gs-4060	737	2	-	-	SYM
gs-4060	737	3	74	74	NUM
gs-4060	737	4	.	.	PUNCT
gs-4060	738	1	2	2	X
gs-4060	738	2	.	.	PUNCT
gs-4060	738	3	sung	sung	PROPN
gs-4060	738	4	h	h	NOUN
gs-4060	738	5	,	,	PUNCT
gs-4060	738	6	ferlay	ferlay	PROPN
gs-4060	738	7	j	j	PROPN
gs-4060	738	8	,	,	PUNCT
gs-4060	738	9	siegel	siegel	PROPN
gs-4060	738	10	rl	rl	PROPN
gs-4060	738	11	,	,	PUNCT
gs-4060	738	12	laversanne	laversanne	NOUN
gs-4060	738	13	m	m	PROPN
gs-4060	738	14	,	,	PUNCT
gs-4060	738	15	soerjomataram	soerjomataram	PROPN
gs-4060	738	16	i	i	PROPN
gs-4060	738	17	,	,	PUNCT
gs-4060	738	18	jemal	jemal	PROPN
gs-4060	738	19	a	a	X
gs-4060	738	20	,	,	PUNCT
gs-4060	738	21	et	et	PROPN
gs-4060	738	22	al	al	PROPN
gs-4060	738	23	.	.	PUNCT
gs-4060	739	1	global	global	ADJ
gs-4060	739	2	cancer	cancer	NOUN
gs-4060	739	3	statistics	statistic	NOUN
gs-4060	739	4	2020	2020	NUM
gs-4060	739	5	:	:	PUNCT
gs-4060	739	6	globocan	globocan	PROPN
gs-4060	739	7	estimates	estimate	NOUN
gs-4060	739	8	of	of	ADP
gs-4060	739	9	incidence	incidence	NOUN
gs-4060	739	10	and	and	CCONJ
gs-4060	739	11	mortality	mortality	NOUN
gs-4060	739	12	worldwide	worldwide	ADV
gs-4060	739	13	for	for	ADP
gs-4060	739	14	36	36	NUM
gs-4060	739	15	cancers	cancer	NOUN
gs-4060	739	16	in	in	ADP
gs-4060	739	17	185	185	NUM
gs-4060	739	18	countries	country	NOUN
gs-4060	739	19	.	.	PUNCT
gs-4060	740	1	ca	can	AUX
gs-4060	740	2	cancer	cancer	PROPN
gs-4060	740	3	j	j	PROPN
gs-4060	740	4	clin	clin	PROPN
gs-4060	740	5	.	.	PUNCT
gs-4060	741	1	2021;71(3):209	2021;71(3):209	NUM
gs-4060	741	2	-	-	PUNCT
gs-4060	741	3	49	49	NUM
gs-4060	741	4	.	.	PUNCT
gs-4060	742	1	3	3	X
gs-4060	742	2	.	.	X
gs-4060	742	3	devita	devita	PROPN
gs-4060	742	4	vt	vt	PROPN
gs-4060	742	5	jr	jr	PROPN
gs-4060	742	6	,	,	PUNCT
gs-4060	742	7	chu	chu	PROPN
gs-4060	742	8	e.	e.	PROPN
gs-4060	742	9	a	a	DET
gs-4060	742	10	history	history	NOUN
gs-4060	742	11	of	of	ADP
gs-4060	742	12	cancer	cancer	NOUN
gs-4060	742	13	chemotherapy	chemotherapy	NOUN
gs-4060	742	14	.	.	PUNCT
gs-4060	743	1	cancer	cancer	NOUN
gs-4060	743	2	res	re	NOUN
gs-4060	743	3	.	.	PUNCT
gs-4060	744	1	2008;68(21):8643	2008;68(21):8643	NUM
gs-4060	744	2	-	-	SYM
gs-4060	744	3	53	53	NUM
gs-4060	744	4	.	.	PUNCT
gs-4060	745	1	georgian	georgian	NOUN
gs-4060	745	2	scientists/	scientists/	NUM
gs-4060	745	3	.	.	PUNCT
gs-4060	746	1	7	7	NUM
gs-4060	746	2	n	n	PRON
gs-4060	746	3	3	3	NUM
gs-4060	746	4	,	,	PUNCT
gs-4060	746	5	2025	2025	NUM
gs-4060	746	6	604	604	NUM
gs-4060	746	7	4	4	NUM
gs-4060	746	8	.	.	PUNCT
gs-4060	747	1	stratton	stratton	PROPN
gs-4060	747	2	mr	mr	PROPN
gs-4060	747	3	,	,	PUNCT
gs-4060	747	4	campbell	campbell	PROPN
gs-4060	747	5	pj	pj	PROPN
gs-4060	747	6	,	,	PUNCT
gs-4060	747	7	futreal	futreal	NOUN
gs-4060	747	8	pa	pa	PROPN
gs-4060	747	9	.	.	PUNCT
gs-4060	748	1	the	the	DET
gs-4060	748	2	cancer	cancer	NOUN
gs-4060	748	3	genome	genome	NOUN
gs-4060	748	4	.	.	PUNCT
gs-4060	749	1	nature	nature	NOUN
gs-4060	749	2	.	.	PUNCT
gs-4060	750	1	2009;458(7239):719	2009;458(7239):719	NUM
gs-4060	750	2	-	-	SYM
gs-4060	750	3	24	24	NUM
gs-4060	750	4	.	.	PUNCT
gs-4060	751	1	5	5	NUM
gs-4060	751	2	.	.	X
gs-4060	752	1	the	the	DET
gs-4060	752	2	cancer	cancer	NOUN
gs-4060	752	3	genome	genome	NOUN
gs-4060	752	4	atlas	atlas	PROPN
gs-4060	752	5	research	research	PROPN
gs-4060	752	6	network	network	NOUN
gs-4060	752	7	.	.	PUNCT
gs-4060	753	1	the	the	DET
gs-4060	753	2	cancer	cancer	NOUN
gs-4060	753	3	genome	genome	NOUN
gs-4060	753	4	atlas	atlas	PROPN
gs-4060	753	5	pan	pan	PROPN
gs-4060	753	6	-	-	ADJ
gs-4060	753	7	cancer	cancer	NOUN
gs-4060	753	8	analysis	analysis	NOUN
gs-4060	753	9	project	project	NOUN
gs-4060	753	10	.	.	PUNCT
gs-4060	754	1	nat	nat	PROPN
gs-4060	754	2	genet	genet	PROPN
gs-4060	754	3	.	.	PUNCT
gs-4060	755	1	2013;45(10):1113	2013;45(10):1113	NUM
gs-4060	755	2	-	-	SYM
gs-4060	755	3	20	20	NUM
gs-4060	755	4	.	.	NOUN
gs-4060	755	5	6	6	NUM
gs-4060	755	6	.	.	X
gs-4060	755	7	druker	druker	NOUN
gs-4060	755	8	bj	bj	PROPN
gs-4060	755	9	,	,	PUNCT
gs-4060	755	10	talpaz	talpaz	PROPN
gs-4060	755	11	m	m	PROPN
gs-4060	755	12	,	,	PUNCT
gs-4060	755	13	resta	resta	PROPN
gs-4060	755	14	dj	dj	PROPN
gs-4060	755	15	,	,	PUNCT
gs-4060	755	16	peng	peng	PROPN
gs-4060	755	17	b	b	PROPN
gs-4060	755	18	,	,	PUNCT
gs-4060	755	19	buchdunger	buchdunger	NOUN
gs-4060	755	20	e	e	NOUN
gs-4060	755	21	,	,	PUNCT
gs-4060	755	22	ford	ford	PROPN
gs-4060	755	23	jm	jm	PROPN
gs-4060	755	24	,	,	PUNCT
gs-4060	755	25	et	et	PROPN
gs-4060	755	26	al	al	PROPN
gs-4060	755	27	.	.	PROPN
gs-4060	755	28	efficacy	efficacy	NOUN
gs-4060	755	29	and	and	CCONJ
gs-4060	755	30	safety	safety	NOUN
gs-4060	755	31	of	of	ADP
gs-4060	755	32	a	a	DET
gs-4060	755	33	specific	specific	ADJ
gs-4060	755	34	inhibitor	inhibitor	NOUN
gs-4060	755	35	of	of	ADP
gs-4060	755	36	the	the	DET
gs-4060	755	37	bcr	bcr	PROPN
gs-4060	755	38	-	-	PUNCT
gs-4060	755	39	abl	abl	PROPN
gs-4060	755	40	tyrosine	tyrosine	PROPN
gs-4060	755	41	kinase	kinase	PROPN
gs-4060	755	42	in	in	ADP
gs-4060	755	43	chronic	chronic	ADJ
gs-4060	755	44	myeloid	myeloid	NOUN
gs-4060	755	45	leukemia	leukemia	NOUN
gs-4060	755	46	.	.	PUNCT
gs-4060	756	1	n	n	PROPN
gs-4060	756	2	engl	engl	PROPN
gs-4060	756	3	j	j	PROPN
gs-4060	756	4	med	med	PROPN
gs-4060	756	5	.	.	PUNCT
gs-4060	757	1	2001;344(14):1031	2001;344(14):1031	NUM
gs-4060	757	2	-	-	PUNCT
gs-4060	757	3	7	7	NUM
gs-4060	757	4	.	.	NOUN
gs-4060	757	5	7	7	NUM
gs-4060	757	6	.	.	PUNCT
gs-4060	757	7	lynch	lynch	PROPN
gs-4060	757	8	tj	tj	PROPN
gs-4060	757	9	,	,	PUNCT
gs-4060	757	10	bell	bell	PROPN
gs-4060	757	11	dw	dw	PROPN
gs-4060	757	12	,	,	PUNCT
gs-4060	757	13	sordella	sordella	PROPN
gs-4060	757	14	r	r	NOUN
gs-4060	757	15	,	,	PUNCT
gs-4060	757	16	gurubhagavatula	gurubhagavatula	NOUN
gs-4060	757	17	s	s	PROPN
gs-4060	757	18	,	,	PUNCT
gs-4060	757	19	okimoto	okimoto	NOUN
gs-4060	757	20	ra	ra	PROPN
gs-4060	757	21	,	,	PUNCT
gs-4060	757	22	brannigan	brannigan	PROPN
gs-4060	757	23	bw	bw	PROPN
gs-4060	757	24	,	,	PUNCT
gs-4060	757	25	et	et	PROPN
gs-4060	757	26	al	al	PROPN
gs-4060	757	27	.	.	PUNCT
gs-4060	757	28	activating	activate	VERB
gs-4060	757	29	mutations	mutation	NOUN
gs-4060	757	30	in	in	ADP
gs-4060	757	31	the	the	DET
gs-4060	757	32	epidermal	epidermal	ADJ
gs-4060	757	33	growth	growth	NOUN
gs-4060	757	34	factor	factor	NOUN
gs-4060	757	35	receptor	receptor	NOUN
gs-4060	757	36	underlying	underlie	VERB
gs-4060	757	37	responsiveness	responsiveness	NOUN
gs-4060	757	38	of	of	ADP
gs-4060	757	39	non	non	ADJ
gs-4060	757	40	-	-	ADJ
gs-4060	757	41	small	small	ADJ
gs-4060	757	42	-	-	PUNCT
gs-4060	757	43	cell	cell	NOUN
gs-4060	757	44	lung	lung	NOUN
gs-4060	757	45	cancer	cancer	NOUN
gs-4060	757	46	to	to	ADP
gs-4060	757	47	gefitinib	gefitinib	NOUN
gs-4060	757	48	.	.	PUNCT
gs-4060	758	1	n	n	PROPN
gs-4060	758	2	engl	engl	PROPN
gs-4060	758	3	j	j	PROPN
gs-4060	758	4	med	med	PROPN
gs-4060	758	5	.	.	PUNCT
gs-4060	759	1	2004;350(21):2129	2004;350(21):2129	NUM
gs-4060	759	2	-	-	SYM
gs-4060	759	3	39	39	NUM
gs-4060	759	4	.	.	PUNCT
gs-4060	760	1	8	8	NUM
gs-4060	760	2	.	.	X
gs-4060	761	1	paez	paez	PROPN
gs-4060	761	2	jg	jg	PROPN
gs-4060	761	3	,	,	PUNCT
gs-4060	761	4	jänne	jänne	PROPN
gs-4060	761	5	pa	pa	PROPN
gs-4060	761	6	,	,	PUNCT
gs-4060	761	7	lee	lee	PROPN
gs-4060	761	8	jc	jc	PROPN
gs-4060	761	9	,	,	PUNCT
gs-4060	761	10	tracy	tracy	PROPN
gs-4060	761	11	s	s	PROPN
gs-4060	761	12	,	,	PUNCT
gs-4060	761	13	greulich	greulich	ADJ
gs-4060	761	14	h	h	NOUN
gs-4060	761	15	,	,	PUNCT
gs-4060	761	16	gabriel	gabriel	PROPN
gs-4060	761	17	s	s	PROPN
gs-4060	761	18	,	,	PUNCT
gs-4060	761	19	et	et	PROPN
gs-4060	761	20	al	al	PROPN
gs-4060	761	21	.	.	PROPN
gs-4060	761	22	egfr	egfr	PROPN
gs-4060	761	23	mutations	mutation	NOUN
gs-4060	761	24	in	in	ADP
gs-4060	761	25	lung	lung	NOUN
gs-4060	761	26	cancer	cancer	NOUN
gs-4060	761	27	:	:	PUNCT
gs-4060	761	28	correlation	correlation	NOUN
gs-4060	761	29	with	with	ADP
gs-4060	761	30	clinical	clinical	ADJ
gs-4060	761	31	response	response	NOUN
gs-4060	761	32	to	to	ADP
gs-4060	761	33	gefitinib	gefitinib	NOUN
gs-4060	761	34	therapy	therapy	NOUN
gs-4060	761	35	.	.	PUNCT
gs-4060	762	1	science	science	NOUN
gs-4060	762	2	.	.	PUNCT
gs-4060	763	1	2004;304(5676):1497	2004;304(5676):1497	NUM
gs-4060	763	2	-	-	SYM
gs-4060	763	3	500	500	NUM
gs-4060	763	4	.	.	PUNCT
gs-4060	764	1	9	9	NUM
gs-4060	764	2	.	.	X
gs-4060	764	3	mok	mok	PROPN
gs-4060	764	4	ts	ts	PROPN
gs-4060	764	5	,	,	PUNCT
gs-4060	764	6	wu	wu	PROPN
gs-4060	764	7	yl	yl	NOUN
gs-4060	764	8	,	,	PUNCT
gs-4060	764	9	thongprasert	thongprasert	PROPN
gs-4060	764	10	s	s	PROPN
gs-4060	764	11	,	,	PUNCT
gs-4060	764	12	yang	yang	PROPN
gs-4060	764	13	ch	ch	PROPN
gs-4060	764	14	,	,	PUNCT
gs-4060	764	15	chu	chu	PROPN
gs-4060	764	16	dt	dt	PROPN
gs-4060	764	17	,	,	PUNCT
gs-4060	764	18	saijo	saijo	PROPN
gs-4060	764	19	n	n	PROPN
gs-4060	764	20	,	,	PUNCT
gs-4060	764	21	et	et	PROPN
gs-4060	764	22	al	al	PROPN
gs-4060	764	23	.	.	PUNCT
gs-4060	764	24	gefitinib	gefitinib	NOUN
gs-4060	764	25	or	or	CCONJ
gs-4060	764	26	carboplatinpaclitaxel	carboplatinpaclitaxel	VERB
gs-4060	764	27	in	in	ADP
gs-4060	764	28	pulmonary	pulmonary	ADJ
gs-4060	764	29	adenocarcinoma	adenocarcinoma	NOUN
gs-4060	764	30	.	.	PUNCT
gs-4060	765	1	n	n	PROPN
gs-4060	765	2	engl	engl	PROPN
gs-4060	765	3	j	j	PROPN
gs-4060	765	4	med	med	PROPN
gs-4060	765	5	.	.	PUNCT
gs-4060	766	1	2009;361(10):947	2009;361(10):947	NUM
gs-4060	766	2	-	-	PROPN
gs-4060	766	3	57	57	NUM
gs-4060	766	4	.	.	PUNCT
gs-4060	767	1	10.rosell	10.rosell	NUM
gs-4060	767	2	r	r	NOUN
gs-4060	767	3	,	,	PUNCT
gs-4060	767	4	carcereny	carcereny	NOUN
gs-4060	767	5	e	e	NOUN
gs-4060	767	6	,	,	PUNCT
gs-4060	767	7	gervais	gervais	PROPN
gs-4060	767	8	r	r	NOUN
gs-4060	767	9	,	,	PUNCT
gs-4060	767	10	vergnenegre	vergnenegre	VERB
gs-4060	767	11	a	a	DET
gs-4060	767	12	,	,	PUNCT
gs-4060	767	13	massuti	massuti	NOUN
gs-4060	767	14	b	b	NUM
gs-4060	767	15	,	,	PUNCT
gs-4060	767	16	felip	felip	NOUN
gs-4060	767	17	e	e	NOUN
gs-4060	767	18	,	,	PUNCT
gs-4060	767	19	et	et	PROPN
gs-4060	767	20	al	al	PROPN
gs-4060	767	21	.	.	PROPN
gs-4060	767	22	erlotinib	erlotinib	PROPN
gs-4060	767	23	versus	versus	ADP
gs-4060	767	24	standard	standard	ADJ
gs-4060	767	25	chemotherapy	chemotherapy	NOUN
gs-4060	767	26	as	as	ADP
gs-4060	767	27	first	first	ADJ
gs-4060	767	28	-	-	PUNCT
gs-4060	767	29	line	line	NOUN
gs-4060	767	30	treatment	treatment	NOUN
gs-4060	767	31	for	for	ADP
gs-4060	767	32	european	european	ADJ
gs-4060	767	33	patients	patient	NOUN
gs-4060	767	34	with	with	ADP
gs-4060	767	35	advanced	advanced	ADJ
gs-4060	767	36	egfr	egfr	ADJ
gs-4060	767	37	mutation	mutation	NOUN
gs-4060	767	38	-	-	PUNCT
gs-4060	767	39	positive	positive	ADJ
gs-4060	767	40	non	non	ADJ
gs-4060	767	41	-	-	ADJ
gs-4060	767	42	small	small	ADJ
gs-4060	767	43	-	-	PUNCT
gs-4060	767	44	cell	cell	NOUN
gs-4060	767	45	lung	lung	NOUN
gs-4060	767	46	cancer	cancer	NOUN
gs-4060	767	47	(	(	PUNCT
gs-4060	767	48	eurtac	eurtac	PROPN
gs-4060	767	49	):	):	PUNCT
gs-4060	767	50	a	a	DET
gs-4060	767	51	multicentre	multicentre	NOUN
gs-4060	767	52	,	,	PUNCT
gs-4060	767	53	open	open	ADJ
gs-4060	767	54	-	-	PUNCT
gs-4060	767	55	label	label	NOUN
gs-4060	767	56	,	,	PUNCT
gs-4060	767	57	randomised	randomise	VERB
gs-4060	767	58	phase	phase	NOUN
gs-4060	767	59	3	3	NUM
gs-4060	767	60	trial	trial	NOUN
gs-4060	767	61	.	.	PUNCT
gs-4060	768	1	lancet	lancet	PROPN
gs-4060	768	2	oncol	oncol	PROPN
gs-4060	768	3	.	.	PUNCT
gs-4060	769	1	2012;13(3):239	2012;13(3):239	NUM
gs-4060	769	2	-	-	SYM
gs-4060	769	3	46	46	NUM
gs-4060	769	4	.	.	PUNCT
gs-4060	770	1	11.soria	11.soria	NUM
gs-4060	770	2	jc	jc	PROPN
gs-4060	770	3	,	,	PUNCT
gs-4060	770	4	ohe	ohe	PROPN
gs-4060	770	5	y	y	PROPN
gs-4060	770	6	,	,	PUNCT
gs-4060	770	7	vansteenkiste	vansteenkiste	PROPN
gs-4060	770	8	j	j	PROPN
gs-4060	770	9	,	,	PUNCT
gs-4060	770	10	reungwetwattana	reungwetwattana	PROPN
gs-4060	770	11	t	t	PROPN
gs-4060	770	12	,	,	PUNCT
gs-4060	770	13	chewaskulyong	chewaskulyong	NOUN
gs-4060	770	14	b	b	PROPN
gs-4060	770	15	,	,	PUNCT
gs-4060	770	16	lee	lee	PROPN
gs-4060	770	17	kh	kh	PROPN
gs-4060	770	18	,	,	PUNCT
gs-4060	771	1	et	et	PROPN
gs-4060	771	2	al	al	PROPN
gs-4060	771	3	.	.	PROPN
gs-4060	771	4	osimertinib	osimertinib	NOUN
gs-4060	771	5	in	in	ADP
gs-4060	771	6	untreated	untreated	ADJ
gs-4060	771	7	egfr	egfr	ADV
gs-4060	771	8	-	-	PUNCT
gs-4060	771	9	mutated	mutate	VERB
gs-4060	771	10	advanced	advanced	ADJ
gs-4060	771	11	non	non	ADJ
gs-4060	771	12	-	-	ADJ
gs-4060	771	13	small	small	ADJ
gs-4060	771	14	-	-	PUNCT
gs-4060	771	15	cell	cell	NOUN
gs-4060	771	16	lung	lung	NOUN
gs-4060	771	17	cancer	cancer	NOUN
gs-4060	771	18	.	.	PUNCT
gs-4060	772	1	n	n	PROPN
gs-4060	772	2	engl	engl	PROPN
gs-4060	772	3	j	j	PROPN
gs-4060	772	4	med	med	PROPN
gs-4060	772	5	.	.	PUNCT
gs-4060	773	1	2018;378(2):113	2018;378(2):113	NUM
gs-4060	773	2	-	-	SYM
gs-4060	773	3	25	25	NUM
gs-4060	773	4	.	.	PUNCT
gs-4060	774	1	12.chapman	12.chapman	NUM
gs-4060	775	1	pb	pb	ADP
gs-4060	775	2	,	,	PUNCT
gs-4060	775	3	hauschild	hauschild	VERB
gs-4060	775	4	a	a	X
gs-4060	775	5	,	,	PUNCT
gs-4060	775	6	robert	robert	PROPN
gs-4060	775	7	c	c	PROPN
gs-4060	775	8	,	,	PUNCT
gs-4060	775	9	haanen	haanen	PROPN
gs-4060	775	10	jb	jb	PROPN
gs-4060	775	11	,	,	PUNCT
gs-4060	775	12	ascierto	ascierto	NOUN
gs-4060	775	13	p	p	PRON
gs-4060	775	14	,	,	PUNCT
gs-4060	775	15	larkin	larkin	PROPN
gs-4060	775	16	j	j	PROPN
gs-4060	775	17	,	,	PUNCT
gs-4060	775	18	et	et	PROPN
gs-4060	775	19	al	al	PROPN
gs-4060	775	20	.	.	PROPN
gs-4060	776	1	improved	improved	ADJ
gs-4060	776	2	survival	survival	NOUN
gs-4060	776	3	with	with	ADP
gs-4060	776	4	vemurafenib	vemurafenib	NOUN
gs-4060	776	5	in	in	ADP
gs-4060	776	6	melanoma	melanoma	NOUN
gs-4060	776	7	with	with	ADP
gs-4060	776	8	braf	braf	NOUN
gs-4060	776	9	v600e	v600e	NOUN
gs-4060	776	10	mutation	mutation	NOUN
gs-4060	776	11	.	.	PUNCT
gs-4060	777	1	n	n	PROPN
gs-4060	777	2	engl	engl	PROPN
gs-4060	777	3	j	j	PROPN
gs-4060	777	4	med	med	PROPN
gs-4060	777	5	.	.	PUNCT
gs-4060	778	1	2011;364(26):250716	2011;364(26):250716	NOUN
gs-4060	778	2	.	.	PUNCT
gs-4060	779	1	13.flaherty	13.flaherty	NUM
gs-4060	779	2	kt	kt	PROPN
gs-4060	779	3	,	,	PUNCT
gs-4060	779	4	robert	robert	PROPN
gs-4060	779	5	c	c	PROPN
gs-4060	779	6	,	,	PUNCT
gs-4060	779	7	hersey	hersey	PROPN
gs-4060	779	8	p	p	PROPN
gs-4060	779	9	,	,	PUNCT
gs-4060	779	10	nathan	nathan	PROPN
gs-4060	779	11	p	p	PROPN
gs-4060	779	12	,	,	PUNCT
gs-4060	779	13	garbe	garbe	NOUN
gs-4060	779	14	c	c	NOUN
gs-4060	779	15	,	,	PUNCT
gs-4060	779	16	milhem	milhem	PROPN
gs-4060	779	17	m	m	PROPN
gs-4060	779	18	,	,	PUNCT
gs-4060	779	19	et	et	PROPN
gs-4060	779	20	al	al	PROPN
gs-4060	779	21	.	.	PROPN
gs-4060	779	22	improved	improved	ADJ
gs-4060	779	23	survival	survival	NOUN
gs-4060	779	24	with	with	ADP
gs-4060	779	25	mek	mek	PROPN
gs-4060	779	26	inhibition	inhibition	NOUN
gs-4060	779	27	in	in	ADP
gs-4060	779	28	braf	braf	NOUN
gs-4060	779	29	-	-	PUNCT
gs-4060	779	30	mutated	mutate	VERB
gs-4060	779	31	melanoma	melanoma	NOUN
gs-4060	779	32	.	.	PUNCT
gs-4060	780	1	n	n	PRON
gs-4060	780	2	engl	engl	PROPN
gs-4060	780	3	j	j	PROPN
gs-4060	780	4	med	med	PROPN
gs-4060	780	5	.	.	PUNCT
gs-4060	781	1	2012;367(2):107	2012;367(2):107	NUM
gs-4060	781	2	-	-	SYM
gs-4060	781	3	14	14	NUM
gs-4060	781	4	.	.	PUNCT
gs-4060	782	1	14.robert	14.robert	PUNCT
gs-4060	782	2	c	c	X
gs-4060	782	3	,	,	PUNCT
gs-4060	782	4	karaszewska	karaszewska	PROPN
gs-4060	782	5	b	b	NUM
gs-4060	782	6	,	,	PUNCT
gs-4060	782	7	schachter	schachter	PROPN
gs-4060	782	8	j	j	PROPN
gs-4060	782	9	,	,	PUNCT
gs-4060	782	10	rutkowski	rutkowski	PROPN
gs-4060	782	11	p	p	X
gs-4060	782	12	,	,	PUNCT
gs-4060	782	13	mackiewicz	mackiewicz	VERB
gs-4060	782	14	a	a	DET
gs-4060	782	15	,	,	PUNCT
gs-4060	782	16	stroiakovski	stroiakovski	ADJ
gs-4060	782	17	d	d	PROPN
gs-4060	782	18	,	,	PUNCT
gs-4060	782	19	et	et	PROPN
gs-4060	782	20	al	al	PROPN
gs-4060	782	21	.	.	PROPN
gs-4060	782	22	improved	improve	VERB
gs-4060	782	23	overall	overall	ADJ
gs-4060	782	24	survival	survival	NOUN
gs-4060	782	25	in	in	ADP
gs-4060	782	26	melanoma	melanoma	NOUN
gs-4060	782	27	with	with	ADP
gs-4060	782	28	combined	combined	ADJ
gs-4060	782	29	dabrafenib	dabrafenib	NOUN
gs-4060	782	30	and	and	CCONJ
gs-4060	782	31	trametinib	trametinib	NOUN
gs-4060	782	32	.	.	PUNCT
gs-4060	783	1	n	n	PROPN
gs-4060	783	2	engl	engl	PROPN
gs-4060	783	3	j	j	PROPN
gs-4060	783	4	med	med	PROPN
gs-4060	783	5	.	.	PUNCT
gs-4060	784	1	2015;372(1):30	2015;372(1):30	NUM
gs-4060	784	2	-	-	SYM
gs-4060	784	3	9	9	NUM
gs-4060	784	4	.	.	PUNCT
gs-4060	785	1	15.finn	15.finn	NUM
gs-4060	785	2	rs	rs	PROPN
gs-4060	785	3	,	,	PUNCT
gs-4060	785	4	martin	martin	PROPN
gs-4060	785	5	m	m	PROPN
gs-4060	785	6	,	,	PUNCT
gs-4060	785	7	rugo	rugo	PROPN
gs-4060	785	8	hs	hs	PROPN
gs-4060	785	9	,	,	PUNCT
gs-4060	785	10	jones	jones	PROPN
gs-4060	785	11	s	s	PROPN
gs-4060	785	12	,	,	PUNCT
gs-4060	785	13	i	i	PRON
gs-4060	785	14	m	m	PROPN
gs-4060	785	15	sa	sa	PROPN
gs-4060	785	16	,	,	PUNCT
gs-4060	785	17	gelmon	gelmon	PROPN
gs-4060	785	18	k	k	PROPN
gs-4060	785	19	,	,	PUNCT
gs-4060	785	20	et	et	PROPN
gs-4060	785	21	al	al	PROPN
gs-4060	785	22	.	.	PROPN
gs-4060	785	23	palbociclib	palbociclib	PROPN
gs-4060	785	24	and	and	CCONJ
gs-4060	785	25	letrozole	letrozole	VERB
gs-4060	785	26	in	in	ADP
gs-4060	785	27	advanced	advanced	ADJ
gs-4060	785	28	breast	breast	NOUN
gs-4060	785	29	cancer	cancer	NOUN
gs-4060	785	30	.	.	PUNCT
gs-4060	786	1	n	n	PROPN
gs-4060	786	2	engl	engl	PROPN
gs-4060	786	3	j	j	PROPN
gs-4060	786	4	med	med	PROPN
gs-4060	786	5	.	.	PUNCT
gs-4060	787	1	2016;375(20):1925	2016;375(20):1925	NUM
gs-4060	787	2	-	-	SYM
gs-4060	787	3	36	36	NUM
gs-4060	787	4	.	.	PUNCT
gs-4060	788	1	16.hortobagyi	16.hortobagyi	NUM
gs-4060	788	2	gn	gn	PROPN
gs-4060	788	3	,	,	PUNCT
gs-4060	788	4	stemmer	stemmer	PROPN
gs-4060	788	5	sm	sm	PROPN
gs-4060	788	6	,	,	PUNCT
gs-4060	788	7	burris	burris	PROPN
gs-4060	788	8	ha	ha	INTJ
gs-4060	788	9	,	,	PUNCT
gs-4060	788	10	yap	yap	PROPN
gs-4060	788	11	ys	ys	PROPN
gs-4060	788	12	,	,	PUNCT
gs-4060	788	13	sonke	sonke	NOUN
gs-4060	788	14	gs	gs	NOUN
gs-4060	788	15	,	,	PUNCT
gs-4060	788	16	paluch	paluch	ADJ
gs-4060	788	17	-	-	PUNCT
gs-4060	788	18	shimon	shimon	PROPN
gs-4060	788	19	s	s	PROPN
gs-4060	788	20	,	,	PUNCT
gs-4060	788	21	et	et	PROPN
gs-4060	788	22	al	al	PROPN
gs-4060	788	23	.	.	PUNCT
gs-4060	788	24	ribociclib	ribociclib	NOUN
gs-4060	788	25	as	as	ADP
gs-4060	788	26	first	first	ADJ
gs-4060	788	27	-	-	PUNCT
gs-4060	788	28	line	line	NOUN
gs-4060	788	29	therapy	therapy	NOUN
gs-4060	788	30	for	for	ADP
gs-4060	788	31	hr	hr	NOUN
gs-4060	788	32	-	-	PUNCT
gs-4060	788	33	positive	positive	ADJ
gs-4060	788	34	,	,	PUNCT
gs-4060	788	35	advanced	advanced	ADJ
gs-4060	788	36	breast	breast	NOUN
gs-4060	788	37	cancer	cancer	NOUN
gs-4060	788	38	.	.	PUNCT
gs-4060	789	1	n	n	PROPN
gs-4060	789	2	engl	engl	PROPN
gs-4060	789	3	j	j	PROPN
gs-4060	789	4	med	med	PROPN
gs-4060	789	5	.	.	PUNCT
gs-4060	790	1	2016;375(20):1738	2016;375(20):1738	NUM
gs-4060	790	2	-	-	SYM
gs-4060	790	3	48	48	NUM
gs-4060	790	4	.	.	PUNCT
gs-4060	791	1	17.goetz	17.goetz	NUM
gs-4060	791	2	mp	mp	PROPN
gs-4060	791	3	,	,	PUNCT
gs-4060	791	4	toi	toi	PROPN
gs-4060	791	5	m	m	PROPN
gs-4060	791	6	,	,	PUNCT
gs-4060	791	7	campone	campone	NOUN
gs-4060	791	8	m	m	PROPN
gs-4060	791	9	,	,	PUNCT
gs-4060	791	10	sohn	sohn	PROPN
gs-4060	791	11	j	j	PROPN
gs-4060	791	12	,	,	PUNCT
gs-4060	791	13	paluch	paluch	PROPN
gs-4060	791	14	-	-	PUNCT
gs-4060	791	15	shimon	shimon	PROPN
gs-4060	791	16	s	s	PROPN
gs-4060	791	17	,	,	PUNCT
gs-4060	791	18	huober	huober	PROPN
gs-4060	791	19	j	j	PROPN
gs-4060	791	20	,	,	PUNCT
gs-4060	791	21	et	et	PROPN
gs-4060	791	22	al	al	PROPN
gs-4060	791	23	.	.	PROPN
gs-4060	791	24	monarch	monarch	PROPN
gs-4060	791	25	3	3	NUM
gs-4060	791	26	:	:	PUNCT
gs-4060	791	27	abemaciclib	abemaciclib	NOUN
gs-4060	791	28	as	as	ADP
gs-4060	791	29	initial	initial	ADJ
gs-4060	791	30	therapy	therapy	NOUN
gs-4060	791	31	for	for	ADP
gs-4060	791	32	advanced	advanced	ADJ
gs-4060	791	33	breast	breast	NOUN
gs-4060	791	34	cancer	cancer	NOUN
gs-4060	791	35	.	.	PUNCT
gs-4060	792	1	j	j	PROPN
gs-4060	792	2	clin	clin	PROPN
gs-4060	792	3	oncol	oncol	PROPN
gs-4060	792	4	.	.	PUNCT
gs-4060	793	1	2017;35(32):363846	2017;35(32):363846	NUM
gs-4060	793	2	.	.	X
gs-4060	794	1	18.ledermann	18.ledermann	NUM
gs-4060	794	2	j	j	NOUN
gs-4060	794	3	,	,	PUNCT
gs-4060	794	4	harter	harter	VERB
gs-4060	794	5	p	p	NOUN
gs-4060	794	6	,	,	PUNCT
gs-4060	794	7	gourley	gourley	PROPN
gs-4060	794	8	c	c	NOUN
gs-4060	794	9	,	,	PUNCT
gs-4060	794	10	friedlander	friedlander	NOUN
gs-4060	794	11	m	m	PRON
gs-4060	794	12	,	,	PUNCT
gs-4060	794	13	vergote	vergote	VERB
gs-4060	794	14	i	i	PRON
gs-4060	794	15	,	,	PUNCT
gs-4060	794	16	rustin	rustin	PROPN
gs-4060	794	17	g	g	PROPN
gs-4060	794	18	,	,	PUNCT
gs-4060	794	19	et	et	PROPN
gs-4060	794	20	al	al	PROPN
gs-4060	794	21	.	.	PROPN
gs-4060	795	1	olaparib	olaparib	PROPN
gs-4060	795	2	maintenance	maintenance	NOUN
gs-4060	795	3	therapy	therapy	NOUN
gs-4060	795	4	in	in	ADP
gs-4060	795	5	platinum	platinum	NOUN
gs-4060	795	6	-	-	PUNCT
gs-4060	795	7	sensitive	sensitive	ADJ
gs-4060	795	8	relapsed	relapse	VERB
gs-4060	795	9	ovarian	ovarian	ADJ
gs-4060	795	10	cancer	cancer	NOUN
gs-4060	795	11	.	.	PUNCT
gs-4060	796	1	n	n	PROPN
gs-4060	796	2	engl	engl	PROPN
gs-4060	796	3	j	j	PROPN
gs-4060	796	4	med	med	PROPN
gs-4060	796	5	.	.	PUNCT
gs-4060	797	1	2012;366(15):1382	2012;366(15):1382	X
gs-4060	797	2	-	-	SYM
gs-4060	797	3	92	92	NUM
gs-4060	797	4	.	.	PUNCT
gs-4060	798	1	19.robson	19.robson	NUM
gs-4060	798	2	m	m	PROPN
gs-4060	798	3	,	,	PUNCT
gs-4060	798	4	i	i	PRON
gs-4060	798	5	m	m	PROPN
gs-4060	798	6	sa	sa	PROPN
gs-4060	798	7	,	,	PUNCT
gs-4060	798	8	senkus	senkus	VERB
gs-4060	798	9	e	e	NOUN
gs-4060	798	10	,	,	PUNCT
gs-4060	798	11	xu	xu	PROPN
gs-4060	799	1	b	b	NUM
gs-4060	799	2	,	,	PUNCT
gs-4060	799	3	domchek	domchek	PROPN
gs-4060	799	4	sm	sm	PROPN
gs-4060	799	5	,	,	PUNCT
gs-4060	799	6	masuda	masuda	PROPN
gs-4060	799	7	n	n	PROPN
gs-4060	799	8	,	,	PUNCT
gs-4060	799	9	et	et	PROPN
gs-4060	799	10	al	al	PROPN
gs-4060	799	11	.	.	PROPN
gs-4060	799	12	olaparib	olaparib	PROPN
gs-4060	799	13	for	for	ADP
gs-4060	799	14	metastatic	metastatic	ADJ
gs-4060	799	15	breast	breast	NOUN
gs-4060	799	16	cancer	cancer	NOUN
gs-4060	799	17	in	in	ADP
gs-4060	799	18	patients	patient	NOUN
gs-4060	799	19	with	with	ADP
gs-4060	799	20	a	a	DET
gs-4060	799	21	germline	germline	NOUN
gs-4060	799	22	brca	brca	PROPN
gs-4060	799	23	mutation	mutation	PROPN
gs-4060	799	24	.	.	PUNCT
gs-4060	800	1	n	n	PROPN
gs-4060	800	2	engl	engl	PROPN
gs-4060	800	3	j	j	PROPN
gs-4060	800	4	med	med	PROPN
gs-4060	800	5	.	.	PUNCT
gs-4060	801	1	2017;377(6):523	2017;377(6):523	NUM
gs-4060	801	2	-	-	SYM
gs-4060	801	3	33	33	NUM
gs-4060	801	4	.	.	PUNCT
gs-4060	802	1	georgian	georgian	NOUN
gs-4060	802	2	scientists/	scientists/	NUM
gs-4060	802	3	.	.	PUNCT
gs-4060	803	1	7	7	NUM
gs-4060	803	2	n	n	PRON
gs-4060	803	3	3	3	NUM
gs-4060	803	4	,	,	PUNCT
gs-4060	803	5	2025	2025	NUM
gs-4060	803	6	605	605	NUM
gs-4060	803	7	20.slamon	20.slamon	NUM
gs-4060	803	8	dj	dj	NOUN
gs-4060	803	9	,	,	PUNCT
gs-4060	803	10	leyland	leyland	PROPN
gs-4060	803	11	-	-	PUNCT
gs-4060	803	12	jones	jones	PROPN
gs-4060	803	13	b	b	PROPN
gs-4060	803	14	,	,	PUNCT
gs-4060	803	15	shak	shak	PROPN
gs-4060	803	16	s	s	PROPN
gs-4060	803	17	,	,	PUNCT
gs-4060	803	18	fuchs	fuchs	PROPN
gs-4060	803	19	h	h	PROPN
gs-4060	803	20	,	,	PUNCT
gs-4060	803	21	paton	paton	PROPN
gs-4060	803	22	v	v	PROPN
gs-4060	803	23	,	,	PUNCT
gs-4060	803	24	bajamonde	bajamonde	VERB
gs-4060	803	25	a	a	PRON
gs-4060	803	26	,	,	PUNCT
gs-4060	803	27	et	et	PROPN
gs-4060	803	28	al	al	PROPN
gs-4060	803	29	.	.	PUNCT
gs-4060	803	30	use	use	NOUN
gs-4060	803	31	of	of	ADP
gs-4060	803	32	chemotherapy	chemotherapy	NOUN
gs-4060	803	33	plus	plus	CCONJ
gs-4060	803	34	a	a	DET
gs-4060	803	35	monoclonal	monoclonal	NOUN
gs-4060	803	36	antibody	antibody	NOUN
gs-4060	803	37	against	against	ADP
gs-4060	803	38	her2	her2	PROPN
gs-4060	803	39	for	for	ADP
gs-4060	803	40	metastatic	metastatic	ADJ
gs-4060	803	41	breast	breast	NOUN
gs-4060	803	42	cancer	cancer	NOUN
gs-4060	803	43	that	that	PRON
gs-4060	803	44	overexpresses	overexpresse	VERB
gs-4060	803	45	her2	her2	VERB
gs-4060	803	46	.	.	PUNCT
gs-4060	804	1	n	n	PROPN
gs-4060	804	2	engl	engl	PROPN
gs-4060	804	3	j	j	PROPN
gs-4060	804	4	med	med	PROPN
gs-4060	804	5	.	.	PUNCT
gs-4060	805	1	2001;344(11):783	2001;344(11):783	NUM
gs-4060	805	2	-	-	SYM
gs-4060	805	3	92	92	NUM
gs-4060	805	4	.	.	PUNCT
gs-4060	806	1	21.bang	21.bang	NUM
gs-4060	806	2	yj	yj	PROPN
gs-4060	806	3	,	,	PUNCT
gs-4060	806	4	van	van	PROPN
gs-4060	806	5	cutsem	cutsem	PROPN
gs-4060	806	6	e	e	NOUN
gs-4060	806	7	,	,	PUNCT
gs-4060	806	8	feyereislova	feyereislova	VERB
gs-4060	806	9	a	a	PRON
gs-4060	806	10	,	,	PUNCT
gs-4060	806	11	chung	chung	PROPN
gs-4060	806	12	hc	hc	PROPN
gs-4060	806	13	,	,	PUNCT
gs-4060	806	14	shen	shen	PROPN
gs-4060	806	15	l	l	PROPN
gs-4060	806	16	,	,	PUNCT
gs-4060	806	17	sawaki	sawaki	X
gs-4060	806	18	a	a	PROPN
gs-4060	806	19	,	,	PUNCT
gs-4060	806	20	et	et	PROPN
gs-4060	806	21	al	al	PROPN
gs-4060	806	22	.	.	PROPN
gs-4060	806	23	trastuzumab	trastuzumab	NOUN
gs-4060	806	24	in	in	ADP
gs-4060	806	25	combination	combination	NOUN
gs-4060	806	26	with	with	ADP
gs-4060	806	27	chemotherapy	chemotherapy	NOUN
gs-4060	806	28	versus	versus	ADP
gs-4060	806	29	chemotherapy	chemotherapy	NOUN
gs-4060	806	30	alone	alone	ADV
gs-4060	806	31	for	for	ADP
gs-4060	806	32	treatment	treatment	NOUN
gs-4060	806	33	of	of	ADP
gs-4060	806	34	her2	her2	PROPN
gs-4060	806	35	-	-	PUNCT
gs-4060	806	36	positive	positive	ADJ
gs-4060	806	37	advanced	advanced	ADJ
gs-4060	806	38	gastric	gastric	ADJ
gs-4060	806	39	or	or	CCONJ
gs-4060	806	40	gastro	gastro	NOUN
gs-4060	806	41	-	-	PUNCT
gs-4060	806	42	oesophageal	oesophageal	NOUN
gs-4060	806	43	junction	junction	NOUN
gs-4060	806	44	cancer	cancer	NOUN
gs-4060	806	45	(	(	PUNCT
gs-4060	806	46	toga	toga	PROPN
gs-4060	806	47	):	):	PUNCT
gs-4060	806	48	a	a	DET
gs-4060	806	49	phase	phase	NOUN
gs-4060	806	50	3	3	NUM
gs-4060	806	51	,	,	PUNCT
gs-4060	806	52	open	open	ADJ
gs-4060	806	53	-	-	PUNCT
gs-4060	806	54	label	label	NOUN
gs-4060	806	55	,	,	PUNCT
gs-4060	806	56	randomised	randomise	VERB
gs-4060	806	57	controlled	control	VERB
gs-4060	806	58	trial	trial	NOUN
gs-4060	806	59	.	.	PUNCT
gs-4060	807	1	lancet	lancet	NOUN
gs-4060	807	2	.	.	PUNCT
gs-4060	808	1	2010;376(9742):687	2010;376(9742):687	NUM
gs-4060	808	2	-	-	SYM
gs-4060	808	3	97	97	NUM
gs-4060	808	4	.	.	PUNCT
gs-4060	809	1	22.verma	22.verma	NUM
gs-4060	809	2	s	s	NOUN
gs-4060	809	3	,	,	PUNCT
gs-4060	809	4	miles	mile	NOUN
gs-4060	809	5	d	d	PROPN
gs-4060	809	6	,	,	PUNCT
gs-4060	809	7	gianni	gianni	PROPN
gs-4060	809	8	l	l	PROPN
gs-4060	809	9	,	,	PUNCT
gs-4060	809	10	krop	krop	PROPN
gs-4060	809	11	ie	ie	X
gs-4060	809	12	,	,	PUNCT
gs-4060	809	13	welslau	welslau	PROPN
gs-4060	809	14	m	m	PROPN
gs-4060	809	15	,	,	PUNCT
gs-4060	809	16	baselga	baselga	PROPN
gs-4060	809	17	j	j	PROPN
gs-4060	809	18	,	,	PUNCT
gs-4060	809	19	et	et	PROPN
gs-4060	809	20	al	al	PROPN
gs-4060	809	21	.	.	PROPN
gs-4060	809	22	trastuzumab	trastuzumab	NOUN
gs-4060	809	23	emtansine	emtansine	NOUN
gs-4060	809	24	for	for	ADP
gs-4060	809	25	her2	her2	NOUN
gs-4060	809	26	-	-	PUNCT
gs-4060	809	27	positive	positive	ADJ
gs-4060	809	28	advanced	advanced	ADJ
gs-4060	809	29	breast	breast	NOUN
gs-4060	809	30	cancer	cancer	NOUN
gs-4060	809	31	.	.	PUNCT
gs-4060	810	1	n	n	PROPN
gs-4060	810	2	engl	engl	PROPN
gs-4060	810	3	j	j	PROPN
gs-4060	810	4	med	med	PROPN
gs-4060	810	5	.	.	PUNCT
gs-4060	811	1	2012;367(19):1783	2012;367(19):1783	NUM
gs-4060	811	2	-	-	PUNCT
gs-4060	811	3	91	91	NUM
gs-4060	811	4	.	.	PUNCT
gs-4060	812	1	23.modi	23.modi	NUM
gs-4060	812	2	s	s	X
gs-4060	812	3	,	,	PUNCT
gs-4060	812	4	saura	saura	PROPN
gs-4060	812	5	c	c	PROPN
gs-4060	812	6	,	,	PUNCT
gs-4060	812	7	yamashita	yamashita	PROPN
gs-4060	812	8	t	t	PROPN
gs-4060	812	9	,	,	PUNCT
gs-4060	812	10	park	park	NOUN
gs-4060	812	11	yh	yh	PROPN
gs-4060	812	12	,	,	PUNCT
gs-4060	812	13	kim	kim	PROPN
gs-4060	812	14	sb	sb	PROPN
gs-4060	812	15	,	,	PUNCT
gs-4060	812	16	tamura	tamura	PROPN
gs-4060	812	17	k	k	PROPN
gs-4060	812	18	,	,	PUNCT
gs-4060	812	19	et	et	PROPN
gs-4060	812	20	al	al	PROPN
gs-4060	812	21	.	.	PROPN
gs-4060	812	22	trastuzumab	trastuzumab	NOUN
gs-4060	812	23	deruxtecan	deruxtecan	NOUN
gs-4060	812	24	in	in	ADP
gs-4060	812	25	previously	previously	ADV
gs-4060	812	26	treated	treat	VERB
gs-4060	812	27	her2	her2	PROPN
gs-4060	812	28	-	-	PUNCT
gs-4060	812	29	positive	positive	ADJ
gs-4060	812	30	breast	breast	NOUN
gs-4060	812	31	cancer	cancer	NOUN
gs-4060	812	32	.	.	PUNCT
gs-4060	813	1	n	n	PROPN
gs-4060	813	2	engl	engl	PROPN
gs-4060	813	3	j	j	PROPN
gs-4060	813	4	med	med	PROPN
gs-4060	813	5	.	.	PUNCT
gs-4060	814	1	2020;382(7):610	2020;382(7):610	NUM
gs-4060	814	2	-	-	SYM
gs-4060	814	3	21	21	NUM
gs-4060	814	4	.	.	PUNCT
gs-4060	815	1	24.hodi	24.hodi	NUM
gs-4060	815	2	fs	f	NOUN
gs-4060	815	3	,	,	PUNCT
gs-4060	815	4	o'day	o'day	PROPN
gs-4060	815	5	sj	sj	PROPN
gs-4060	815	6	,	,	PUNCT
gs-4060	815	7	mcdermott	mcdermott	PROPN
gs-4060	815	8	df	df	PROPN
gs-4060	815	9	,	,	PUNCT
gs-4060	815	10	weber	weber	PROPN
gs-4060	815	11	rw	rw	PROPN
gs-4060	815	12	,	,	PUNCT
gs-4060	815	13	sosman	sosman	NOUN
gs-4060	815	14	ja	ja	PROPN
gs-4060	815	15	,	,	PUNCT
gs-4060	815	16	haanen	haanen	PROPN
gs-4060	815	17	jb	jb	PROPN
gs-4060	815	18	,	,	PUNCT
gs-4060	815	19	et	et	PROPN
gs-4060	815	20	al	al	PROPN
gs-4060	815	21	.	.	PROPN
gs-4060	815	22	improved	improved	ADJ
gs-4060	815	23	survival	survival	NOUN
gs-4060	815	24	with	with	ADP
gs-4060	815	25	ipilimumab	ipilimumab	NOUN
gs-4060	815	26	in	in	ADP
gs-4060	815	27	patients	patient	NOUN
gs-4060	815	28	with	with	ADP
gs-4060	815	29	metastatic	metastatic	ADJ
gs-4060	815	30	melanoma	melanoma	NOUN
gs-4060	815	31	.	.	PUNCT
gs-4060	816	1	n	n	PRON
gs-4060	816	2	engl	engl	PROPN
gs-4060	816	3	j	j	PROPN
gs-4060	816	4	med	med	PROPN
gs-4060	816	5	.	.	PUNCT
gs-4060	817	1	2010;363(8):711	2010;363(8):711	NOUN
gs-4060	817	2	-	-	SYM
gs-4060	817	3	23	23	NUM
gs-4060	817	4	.	.	PUNCT
gs-4060	818	1	25.topalian	25.topalian	NUM
gs-4060	818	2	sl	sl	PROPN
gs-4060	818	3	,	,	PUNCT
gs-4060	818	4	hodi	hodi	PROPN
gs-4060	818	5	fs	fs	PROPN
gs-4060	818	6	,	,	PUNCT
gs-4060	818	7	brahmer	brahmer	PROPN
gs-4060	818	8	jr	jr	PROPN
gs-4060	818	9	,	,	PUNCT
gs-4060	818	10	gettinger	gettinger	PROPN
gs-4060	818	11	sn	sn	PROPN
gs-4060	818	12	,	,	PUNCT
gs-4060	818	13	smith	smith	PROPN
gs-4060	818	14	dc	dc	PROPN
gs-4060	818	15	,	,	PUNCT
gs-4060	818	16	mcdermott	mcdermott	PROPN
gs-4060	818	17	df	df	PROPN
gs-4060	818	18	,	,	PUNCT
gs-4060	818	19	et	et	PROPN
gs-4060	818	20	al	al	PROPN
gs-4060	818	21	.	.	PROPN
gs-4060	818	22	safety	safety	PROPN
gs-4060	818	23	,	,	PUNCT
gs-4060	818	24	activity	activity	NOUN
gs-4060	818	25	,	,	PUNCT
gs-4060	818	26	and	and	CCONJ
gs-4060	818	27	immune	immune	ADJ
gs-4060	818	28	correlates	correlate	VERB
gs-4060	818	29	of	of	ADP
gs-4060	818	30	anti	anti	ADJ
gs-4060	818	31	-	-	ADJ
gs-4060	818	32	pd-1	pd-1	ADJ
gs-4060	818	33	antibody	antibody	NOUN
gs-4060	818	34	in	in	ADP
gs-4060	818	35	cancer	cancer	NOUN
gs-4060	818	36	.	.	PUNCT
gs-4060	819	1	n	n	PROPN
gs-4060	819	2	engl	engl	PROPN
gs-4060	819	3	j	j	PROPN
gs-4060	819	4	med	med	PROPN
gs-4060	819	5	.	.	PUNCT
gs-4060	820	1	2012;366(26):2443	2012;366(26):2443	NUM
gs-4060	820	2	-	-	SYM
gs-4060	820	3	54	54	NUM
gs-4060	820	4	.	.	PUNCT
gs-4060	821	1	26.brahmer	26.brahmer	NUM
gs-4060	821	2	jr	jr	PROPN
gs-4060	821	3	,	,	PUNCT
gs-4060	821	4	tykodi	tykodi	PROPN
gs-4060	821	5	ss	ss	PROPN
gs-4060	821	6	,	,	PUNCT
gs-4060	821	7	chow	chow	PROPN
gs-4060	821	8	lq	lq	VERB
gs-4060	821	9	,	,	PUNCT
gs-4060	821	10	hwu	hwu	VERB
gs-4060	821	11	wj	wj	NOUN
gs-4060	821	12	,	,	PUNCT
gs-4060	821	13	topalian	topalian	NOUN
gs-4060	821	14	sl	sl	PROPN
gs-4060	821	15	,	,	PUNCT
gs-4060	821	16	hwu	hwu	VERB
gs-4060	821	17	p	p	X
gs-4060	821	18	,	,	PUNCT
gs-4060	821	19	et	et	PROPN
gs-4060	821	20	al	al	PROPN
gs-4060	821	21	.	.	PROPN
gs-4060	821	22	safety	safety	NOUN
gs-4060	821	23	and	and	CCONJ
gs-4060	821	24	activity	activity	NOUN
gs-4060	821	25	of	of	ADP
gs-4060	821	26	anti	anti	ADJ
gs-4060	821	27	-	-	ADJ
gs-4060	821	28	pd	pd	ADJ
gs-4060	821	29	-	-	PUNCT
gs-4060	821	30	l1	l1	PROPN
gs-4060	821	31	antibody	antibody	NOUN
gs-4060	821	32	in	in	ADP
gs-4060	821	33	patients	patient	NOUN
gs-4060	821	34	with	with	ADP
gs-4060	821	35	advanced	advanced	ADJ
gs-4060	821	36	cancer	cancer	NOUN
gs-4060	821	37	.	.	PUNCT
gs-4060	822	1	n	n	PROPN
gs-4060	822	2	engl	engl	PROPN
gs-4060	822	3	j	j	PROPN
gs-4060	822	4	med	med	PROPN
gs-4060	822	5	.	.	PUNCT
gs-4060	823	1	2012;366(26):2455	2012;366(26):2455	NUM
gs-4060	823	2	-	-	SYM
gs-4060	823	3	65	65	NUM
gs-4060	823	4	.	.	PUNCT
gs-4060	824	1	27.robert	27.robert	NUM
gs-4060	825	1	c	c	X
gs-4060	825	2	,	,	PUNCT
gs-4060	825	3	long	long	ADV
gs-4060	825	4	gv	gv	ADP
gs-4060	825	5	,	,	PUNCT
gs-4060	825	6	brady	brady	PROPN
gs-4060	825	7	b	b	PROPN
gs-4060	825	8	,	,	PUNCT
gs-4060	825	9	dutriaux	dutriaux	ADJ
gs-4060	825	10	c	c	X
gs-4060	825	11	,	,	PUNCT
gs-4060	825	12	maio	maio	PROPN
gs-4060	825	13	m	m	PROPN
gs-4060	825	14	,	,	PUNCT
gs-4060	825	15	mortier	mortier	PROPN
gs-4060	825	16	l	l	PROPN
gs-4060	825	17	,	,	PUNCT
gs-4060	825	18	et	et	PROPN
gs-4060	825	19	al	al	PROPN
gs-4060	825	20	.	.	PROPN
gs-4060	825	21	nivolumab	nivolumab	NOUN
gs-4060	825	22	in	in	ADP
gs-4060	825	23	previously	previously	ADV
gs-4060	825	24	untreated	untreated	ADJ
gs-4060	825	25	melanoma	melanoma	NOUN
gs-4060	825	26	without	without	ADP
gs-4060	825	27	braf	braf	NOUN
gs-4060	825	28	mutation	mutation	NOUN
gs-4060	825	29	.	.	PUNCT
gs-4060	826	1	n	n	PROPN
gs-4060	826	2	engl	engl	PROPN
gs-4060	826	3	j	j	PROPN
gs-4060	826	4	med	med	PROPN
gs-4060	826	5	.	.	PUNCT
gs-4060	827	1	2015;372(4):320	2015;372(4):320	NUM
gs-4060	827	2	-	-	SYM
gs-4060	827	3	30	30	NUM
gs-4060	827	4	.	.	PUNCT
gs-4060	828	1	28.garon	28.garon	NUM
gs-4060	828	2	eb	eb	PROPN
gs-4060	828	3	,	,	PUNCT
gs-4060	828	4	rizvi	rizvi	ADJ
gs-4060	828	5	na	na	PROPN
gs-4060	828	6	,	,	PUNCT
gs-4060	828	7	hui	hui	PROPN
gs-4060	828	8	r	r	PROPN
gs-4060	828	9	,	,	PUNCT
gs-4060	828	10	leighl	leighl	NOUN
gs-4060	828	11	n	n	PART
gs-4060	828	12	,	,	PUNCT
gs-4060	828	13	balmanoukian	balmanoukian	NOUN
gs-4060	828	14	as	as	ADP
gs-4060	828	15	,	,	PUNCT
gs-4060	828	16	eder	eder	NOUN
gs-4060	828	17	jp	jp	NOUN
gs-4060	828	18	,	,	PUNCT
gs-4060	828	19	et	et	PROPN
gs-4060	828	20	al	al	PROPN
gs-4060	828	21	.	.	PROPN
gs-4060	828	22	pembrolizumab	pembrolizumab	NOUN
gs-4060	828	23	for	for	ADP
gs-4060	828	24	the	the	DET
gs-4060	828	25	treatment	treatment	NOUN
gs-4060	828	26	of	of	ADP
gs-4060	828	27	non	non	ADJ
gs-4060	828	28	-	-	ADJ
gs-4060	828	29	small	small	ADJ
gs-4060	828	30	-	-	PUNCT
gs-4060	828	31	cell	cell	NOUN
gs-4060	828	32	lung	lung	NOUN
gs-4060	828	33	cancer	cancer	NOUN
gs-4060	828	34	.	.	PUNCT
gs-4060	829	1	n	n	PROPN
gs-4060	829	2	engl	engl	PROPN
gs-4060	829	3	j	j	PROPN
gs-4060	829	4	med	med	PROPN
gs-4060	829	5	.	.	PUNCT
gs-4060	830	1	2015;372(21):2018	2015;372(21):2018	PROPN
gs-4060	830	2	-	-	SYM
gs-4060	830	3	28	28	NUM
gs-4060	830	4	.	.	PUNCT
gs-4060	831	1	29.larkin	29.larkin	NUM
gs-4060	832	1	j	j	PROPN
gs-4060	832	2	,	,	PUNCT
gs-4060	832	3	chiarion	chiarion	NOUN
gs-4060	832	4	-	-	PUNCT
gs-4060	832	5	sileni	sileni	NOUN
gs-4060	832	6	v	v	NOUN
gs-4060	832	7	,	,	PUNCT
gs-4060	832	8	gonzalez	gonzalez	PROPN
gs-4060	832	9	r	r	PROPN
gs-4060	832	10	,	,	PUNCT
gs-4060	832	11	grob	grob	PROPN
gs-4060	832	12	jj	jj	PROPN
gs-4060	832	13	,	,	PUNCT
gs-4060	832	14	cowey	cowey	PROPN
gs-4060	832	15	cl	cl	PROPN
gs-4060	832	16	,	,	PUNCT
gs-4060	832	17	lao	lao	PROPN
gs-4060	832	18	cd	cd	PROPN
gs-4060	832	19	,	,	PUNCT
gs-4060	832	20	et	et	PROPN
gs-4060	832	21	al	al	PROPN
gs-4060	832	22	.	.	PROPN
gs-4060	833	1	combined	combine	VERB
gs-4060	833	2	nivolumab	nivolumab	NOUN
gs-4060	833	3	and	and	CCONJ
gs-4060	833	4	ipilimumab	ipilimumab	VERB
gs-4060	833	5	or	or	CCONJ
gs-4060	833	6	monotherapy	monotherapy	NOUN
gs-4060	833	7	in	in	ADP
gs-4060	833	8	untreated	untreated	ADJ
gs-4060	833	9	melanoma	melanoma	NOUN
gs-4060	833	10	.	.	PUNCT
gs-4060	834	1	n	n	PRON
gs-4060	834	2	engl	engl	PROPN
gs-4060	834	3	j	j	PROPN
gs-4060	834	4	med	med	PROPN
gs-4060	834	5	.	.	PUNCT
gs-4060	835	1	2015;373(1):23	2015;373(1):23	X
gs-4060	835	2	-	-	SYM
gs-4060	835	3	34	34	NUM
gs-4060	835	4	.	.	PUNCT
gs-4060	836	1	30.motzer	30.motzer	NUM
gs-4060	836	2	rj	rj	PROPN
gs-4060	836	3	,	,	PUNCT
gs-4060	836	4	tannir	tannir	PROPN
gs-4060	836	5	nm	nm	PROPN
gs-4060	836	6	,	,	PUNCT
gs-4060	836	7	mcdermott	mcdermott	PROPN
gs-4060	836	8	df	df	PROPN
gs-4060	836	9	,	,	PUNCT
gs-4060	836	10	arén	arén	VERB
gs-4060	836	11	frontera	frontera	PROPN
gs-4060	836	12	o	o	PROPN
gs-4060	836	13	,	,	PUNCT
gs-4060	836	14	melichar	melichar	PROPN
gs-4060	836	15	b	b	NUM
gs-4060	836	16	,	,	PUNCT
gs-4060	836	17	choueiri	choueiri	NOUN
gs-4060	836	18	tk	tk	PROPN
gs-4060	836	19	,	,	PUNCT
gs-4060	836	20	et	et	PROPN
gs-4060	836	21	al	al	PROPN
gs-4060	836	22	.	.	PROPN
gs-4060	836	23	nivolumab	nivolumab	PROPN
gs-4060	836	24	plus	plus	CCONJ
gs-4060	836	25	ipilimumab	ipilimumab	X
gs-4060	836	26	versus	versus	ADP
gs-4060	836	27	sunitinib	sunitinib	NOUN
gs-4060	836	28	in	in	ADP
gs-4060	836	29	advanced	advanced	ADJ
gs-4060	836	30	renal	renal	ADJ
gs-4060	836	31	-	-	PUNCT
gs-4060	836	32	cell	cell	NOUN
gs-4060	836	33	carcinoma	carcinoma	NOUN
gs-4060	836	34	.	.	PUNCT
gs-4060	837	1	n	n	PRON
gs-4060	837	2	engl	engl	PROPN
gs-4060	837	3	j	j	PROPN
gs-4060	837	4	med	med	PROPN
gs-4060	837	5	.	.	PUNCT
gs-4060	838	1	2018;378(14):1277	2018;378(14):1277	NUM
gs-4060	838	2	-	-	PUNCT
gs-4060	838	3	90	90	NUM
gs-4060	838	4	.	.	PUNCT
gs-4060	839	1	31.hellmann	31.hellmann	NUM
gs-4060	839	2	md	md	PROPN
gs-4060	839	3	,	,	PUNCT
gs-4060	839	4	paz	paz	NOUN
gs-4060	839	5	-	-	PUNCT
gs-4060	839	6	ares	are	NOUN
gs-4060	839	7	l	l	NOUN
gs-4060	839	8	,	,	PUNCT
gs-4060	839	9	bernabe	bernabe	ADP
gs-4060	839	10	caro	caro	PROPN
gs-4060	839	11	r	r	PROPN
gs-4060	839	12	,	,	PUNCT
gs-4060	839	13	zurawski	zurawski	PROPN
gs-4060	839	14	b	b	PROPN
gs-4060	839	15	,	,	PUNCT
gs-4060	839	16	kim	kim	PROPN
gs-4060	839	17	sw	sw	PROPN
gs-4060	839	18	,	,	PUNCT
gs-4060	839	19	carcereny	carcereny	PROPN
gs-4060	839	20	costa	costa	PROPN
gs-4060	839	21	e	e	PROPN
gs-4060	839	22	,	,	PUNCT
gs-4060	839	23	et	et	PROPN
gs-4060	839	24	al	al	PROPN
gs-4060	839	25	.	.	PROPN
gs-4060	839	26	nivolumab	nivolumab	PROPN
gs-4060	839	27	plus	plus	CCONJ
gs-4060	839	28	ipilimumab	ipilimumab	VERB
gs-4060	839	29	in	in	ADP
gs-4060	839	30	advanced	advanced	ADJ
gs-4060	839	31	non	non	ADJ
gs-4060	839	32	-	-	ADJ
gs-4060	839	33	small	small	ADJ
gs-4060	839	34	-	-	PUNCT
gs-4060	839	35	cell	cell	NOUN
gs-4060	839	36	lung	lung	NOUN
gs-4060	839	37	cancer	cancer	NOUN
gs-4060	839	38	.	.	PUNCT
gs-4060	840	1	n	n	PROPN
gs-4060	840	2	engl	engl	PROPN
gs-4060	840	3	j	j	PROPN
gs-4060	840	4	med	med	PROPN
gs-4060	840	5	.	.	PUNCT
gs-4060	841	1	2019;381(21):2020	2019;381(21):2020	X
gs-4060	841	2	-	-	SYM
gs-4060	841	3	31	31	NUM
gs-4060	841	4	.	.	PUNCT
gs-4060	842	1	32.maude	32.maude	NUM
gs-4060	843	1	sl	sl	PROPN
gs-4060	843	2	,	,	PUNCT
gs-4060	843	3	laetsch	laetsch	PROPN
gs-4060	843	4	tw	tw	PROPN
gs-4060	843	5	,	,	PUNCT
gs-4060	843	6	buechner	buechner	PROPN
gs-4060	843	7	j	j	PROPN
gs-4060	843	8	,	,	PUNCT
gs-4060	843	9	rives	rives	PROPN
gs-4060	843	10	s	s	PROPN
gs-4060	843	11	,	,	PUNCT
gs-4060	843	12	boyer	boyer	PROPN
gs-4060	843	13	m	m	PROPN
gs-4060	843	14	,	,	PUNCT
gs-4060	843	15	bittencourt	bittencourt	PROPN
gs-4060	843	16	h	h	NOUN
gs-4060	843	17	,	,	PUNCT
gs-4060	843	18	et	et	PROPN
gs-4060	843	19	al	al	PROPN
gs-4060	843	20	.	.	PROPN
gs-4060	843	21	tisagenlecleucel	tisagenlecleucel	PROPN
gs-4060	843	22	in	in	ADP
gs-4060	843	23	children	child	NOUN
gs-4060	843	24	and	and	CCONJ
gs-4060	843	25	young	young	ADJ
gs-4060	843	26	adults	adult	NOUN
gs-4060	843	27	with	with	ADP
gs-4060	843	28	b	b	NOUN
gs-4060	843	29	-	-	PUNCT
gs-4060	843	30	cell	cell	NOUN
gs-4060	843	31	lymphoblastic	lymphoblastic	ADJ
gs-4060	843	32	leukemia	leukemia	NOUN
gs-4060	843	33	.	.	PUNCT
gs-4060	844	1	n	n	CCONJ
gs-4060	844	2	engl	engl	PROPN
gs-4060	844	3	j	j	PROPN
gs-4060	844	4	med	med	PROPN
gs-4060	844	5	.	.	PUNCT
gs-4060	845	1	2018;378(5):439	2018;378(5):439	NUM
gs-4060	845	2	-	-	SYM
gs-4060	845	3	48	48	NUM
gs-4060	845	4	.	.	PUNCT
gs-4060	846	1	33.neelapu	33.neelapu	NUM
gs-4060	846	2	ss	ss	PROPN
gs-4060	846	3	,	,	PUNCT
gs-4060	846	4	locke	locke	PROPN
gs-4060	846	5	fl	fl	PROPN
gs-4060	846	6	,	,	PUNCT
gs-4060	846	7	bartlett	bartlett	PROPN
gs-4060	846	8	nl	nl	PROPN
gs-4060	846	9	,	,	PUNCT
gs-4060	846	10	lekakis	lekakis	PROPN
gs-4060	846	11	lj	lj	PROPN
gs-4060	846	12	,	,	PUNCT
gs-4060	846	13	miklos	miklos	PROPN
gs-4060	846	14	db	db	PROPN
gs-4060	846	15	,	,	PUNCT
gs-4060	846	16	jacobson	jacobson	PROPN
gs-4060	846	17	ca	can	AUX
gs-4060	846	18	,	,	PUNCT
gs-4060	846	19	et	et	PROPN
gs-4060	846	20	al	al	PROPN
gs-4060	846	21	.	.	PROPN
gs-4060	846	22	axicabtagene	axicabtagene	PROPN
gs-4060	846	23	ciloleucel	ciloleucel	PROPN
gs-4060	846	24	car	car	PROPN
gs-4060	846	25	t	t	NOUN
gs-4060	846	26	-	-	PUNCT
gs-4060	846	27	cell	cell	NOUN
gs-4060	846	28	therapy	therapy	NOUN
gs-4060	846	29	in	in	ADP
gs-4060	846	30	refractory	refractory	NOUN
gs-4060	846	31	large	large	ADJ
gs-4060	846	32	b	b	NOUN
gs-4060	846	33	-	-	PUNCT
gs-4060	846	34	cell	cell	NOUN
gs-4060	846	35	lymphoma	lymphoma	NOUN
gs-4060	846	36	.	.	PUNCT
gs-4060	847	1	n	n	CCONJ
gs-4060	847	2	engl	engl	PROPN
gs-4060	847	3	j	j	PROPN
gs-4060	847	4	med	med	PROPN
gs-4060	847	5	.	.	PUNCT
gs-4060	848	1	2017;377(26):2531	2017;377(26):2531	NUM
gs-4060	848	2	-	-	SYM
gs-4060	848	3	44	44	NUM
gs-4060	848	4	.	.	PUNCT
gs-4060	849	1	34.st	34.st	NUM
gs-4060	849	2	.	.	PUNCT
gs-4060	850	1	jude	jude	PROPN
gs-4060	850	2	children	children	PROPN
gs-4060	850	3	's	's	PART
gs-4060	850	4	research	research	NOUN
gs-4060	850	5	hospital	hospital	NOUN
gs-4060	850	6	.	.	PUNCT
gs-4060	851	1	the	the	DET
gs-4060	851	2	encode	encode	ADJ
gs-4060	851	3	project	project	NOUN
gs-4060	851	4	consortium	consortium	NOUN
gs-4060	851	5	.	.	PUNCT
gs-4060	852	1	an	an	DET
gs-4060	852	2	integrated	integrated	ADJ
gs-4060	852	3	encyclopedia	encyclopedia	NOUN
gs-4060	852	4	of	of	ADP
gs-4060	852	5	dna	dna	PROPN
gs-4060	852	6	elements	element	NOUN
gs-4060	852	7	in	in	ADP
gs-4060	852	8	the	the	DET
gs-4060	852	9	human	human	ADJ
gs-4060	852	10	genome	genome	NOUN
gs-4060	852	11	.	.	PUNCT
gs-4060	853	1	nature	nature	NOUN
gs-4060	853	2	.	.	PUNCT
gs-4060	854	1	2012;489(7414):57	2012;489(7414):57	X
gs-4060	854	2	-	-	PUNCT
gs-4060	854	3	74	74	NUM
gs-4060	854	4	.	.	PUNCT
gs-4060	855	1	35.schwaederle	35.schwaederle	NUM
gs-4060	855	2	m	m	NOUN
gs-4060	855	3	,	,	PUNCT
gs-4060	855	4	zhao	zhao	PROPN
gs-4060	855	5	m	m	PROPN
gs-4060	855	6	,	,	PUNCT
gs-4060	855	7	lee	lee	PROPN
gs-4060	855	8	jj	jj	PROPN
gs-4060	855	9	,	,	PUNCT
gs-4060	855	10	eggermont	eggermont	PROPN
gs-4060	855	11	am	be	AUX
gs-4060	855	12	,	,	PUNCT
gs-4060	855	13	schilsky	schilsky	ADJ
gs-4060	855	14	rl	rl	PROPN
gs-4060	855	15	,	,	PUNCT
gs-4060	855	16	mendelsohn	mendelsohn	PROPN
gs-4060	855	17	j	j	PROPN
gs-4060	855	18	,	,	PUNCT
gs-4060	855	19	et	et	PROPN
gs-4060	855	20	al	al	PROPN
gs-4060	855	21	.	.	PROPN
gs-4060	855	22	impact	impact	NOUN
gs-4060	855	23	of	of	ADP
gs-4060	855	24	precision	precision	NOUN
gs-4060	855	25	medicine	medicine	NOUN
gs-4060	855	26	in	in	ADP
gs-4060	855	27	diverse	diverse	ADJ
gs-4060	855	28	cancers	cancer	NOUN
gs-4060	855	29	:	:	PUNCT
gs-4060	855	30	a	a	DET
gs-4060	855	31	meta	meta	ADJ
gs-4060	855	32	-	-	PUNCT
gs-4060	855	33	analysis	analysis	NOUN
gs-4060	855	34	of	of	ADP
gs-4060	855	35	phase	phase	NOUN
gs-4060	855	36	ii	ii	NOUN
gs-4060	855	37	clinical	clinical	ADJ
gs-4060	855	38	trials	trial	NOUN
gs-4060	855	39	.	.	PUNCT
gs-4060	856	1	j	j	PROPN
gs-4060	856	2	clin	clin	PROPN
gs-4060	856	3	oncol	oncol	PROPN
gs-4060	856	4	.	.	PUNCT
gs-4060	857	1	2015;33(32):3817	2015;33(32):3817	X
gs-4060	857	2	-	-	SYM
gs-4060	857	3	25	25	NUM
gs-4060	857	4	.	.	PUNCT
gs-4060	858	1	36.janne	36.janne	NUM
gs-4060	858	2	pa	pa	PROPN
gs-4060	858	3	,	,	PUNCT
gs-4060	858	4	yang	yang	PROPN
gs-4060	858	5	jc	jc	PROPN
gs-4060	858	6	,	,	PUNCT
gs-4060	858	7	kim	kim	PROPN
gs-4060	858	8	dw	dw	PROPN
gs-4060	858	9	,	,	PUNCT
gs-4060	858	10	planchard	planchard	PROPN
gs-4060	858	11	d	d	PROPN
gs-4060	858	12	,	,	PUNCT
gs-4060	858	13	ohe	ohe	PROPN
gs-4060	858	14	y	y	PROPN
gs-4060	858	15	,	,	PUNCT
gs-4060	858	16	ramalingam	ramalingam	ADJ
gs-4060	858	17	ss	ss	PROPN
gs-4060	858	18	,	,	PUNCT
gs-4060	858	19	et	et	PROPN
gs-4060	858	20	al	al	PROPN
gs-4060	858	21	.	.	PROPN
gs-4060	858	22	azd9291	azd9291	PROPN
gs-4060	858	23	in	in	ADP
gs-4060	858	24	egfr	egfr	ADJ
gs-4060	858	25	inhibitor	inhibitor	NOUN
gs-4060	858	26	-	-	PUNCT
gs-4060	858	27	resistant	resistant	ADJ
gs-4060	858	28	non	non	ADJ
gs-4060	858	29	-	-	ADJ
gs-4060	858	30	small	small	ADJ
gs-4060	858	31	-	-	PUNCT
gs-4060	858	32	cell	cell	NOUN
gs-4060	858	33	lung	lung	NOUN
gs-4060	858	34	cancer	cancer	NOUN
gs-4060	858	35	.	.	PUNCT
gs-4060	859	1	n	n	PROPN
gs-4060	859	2	engl	engl	PROPN
gs-4060	859	3	j	j	PROPN
gs-4060	859	4	med	med	PROPN
gs-4060	859	5	.	.	PUNCT
gs-4060	860	1	2015;372(18):1689	2015;372(18):1689	NUM
gs-4060	860	2	-	-	SYM
gs-4060	860	3	99	99	NUM
gs-4060	860	4	.	.	PUNCT
gs-4060	861	1	georgian	georgian	NOUN
gs-4060	861	2	scientists/	scientists/	NUM
gs-4060	861	3	.	.	PUNCT
gs-4060	862	1	7	7	NUM
gs-4060	862	2	n	n	PRON
gs-4060	862	3	3	3	NUM
gs-4060	862	4	,	,	PUNCT
gs-4060	862	5	2025	2025	NUM
gs-4060	862	6	606	606	NUM
gs-4060	862	7	37.shaw	37.shaw	NUM
gs-4060	862	8	at	at	ADP
gs-4060	862	9	,	,	PUNCT
gs-4060	862	10	kim	kim	PROPN
gs-4060	862	11	dw	dw	PROPN
gs-4060	862	12	,	,	PUNCT
gs-4060	862	13	nakagawa	nakagawa	PROPN
gs-4060	862	14	k	k	PROPN
gs-4060	862	15	,	,	PUNCT
gs-4060	862	16	seto	seto	PROPN
gs-4060	862	17	t	t	PROPN
gs-4060	862	18	,	,	PUNCT
gs-4060	862	19	crinò	crinò	ADJ
gs-4060	862	20	l	l	NOUN
gs-4060	862	21	,	,	PUNCT
gs-4060	862	22	ahn	ahn	PROPN
gs-4060	862	23	mj	mj	PROPN
gs-4060	862	24	,	,	PUNCT
gs-4060	862	25	et	et	PROPN
gs-4060	862	26	al	al	PROPN
gs-4060	862	27	.	.	PROPN
gs-4060	863	1	crizotinib	crizotinib	PROPN
gs-4060	863	2	versus	versus	ADP
gs-4060	863	3	chemotherapy	chemotherapy	NOUN
gs-4060	863	4	in	in	ADP
gs-4060	863	5	advanced	advanced	ADJ
gs-4060	863	6	alk	alk	VERB
gs-4060	863	7	-	-	PUNCT
gs-4060	863	8	positive	positive	ADJ
gs-4060	863	9	lung	lung	NOUN
gs-4060	863	10	cancer	cancer	NOUN
gs-4060	863	11	.	.	PUNCT
gs-4060	864	1	n	n	PROPN
gs-4060	864	2	engl	engl	PROPN
gs-4060	864	3	j	j	PROPN
gs-4060	864	4	med	med	PROPN
gs-4060	864	5	.	.	PUNCT
gs-4060	865	1	2013;368(25):2385	2013;368(25):2385	NUM
gs-4060	865	2	-	-	SYM
gs-4060	865	3	94	94	NUM
gs-4060	865	4	.	.	PUNCT
gs-4060	866	1	38.solomon	38.solomon	NUM
gs-4060	866	2	bj	bj	NOUN
gs-4060	866	3	,	,	PUNCT
gs-4060	866	4	mok	mok	PROPN
gs-4060	866	5	t	t	PROPN
gs-4060	866	6	,	,	PUNCT
gs-4060	866	7	kim	kim	PROPN
gs-4060	866	8	dw	dw	PROPN
gs-4060	866	9	,	,	PUNCT
gs-4060	866	10	wu	wu	PROPN
gs-4060	866	11	yl	yl	PROPN
gs-4060	866	12	,	,	PUNCT
gs-4060	866	13	nakagawa	nakagawa	PROPN
gs-4060	866	14	k	k	PROPN
gs-4060	866	15	,	,	PUNCT
gs-4060	866	16	mekhail	mekhail	PROPN
gs-4060	866	17	t	t	PROPN
gs-4060	866	18	,	,	PUNCT
gs-4060	866	19	et	et	PROPN
gs-4060	866	20	al	al	PROPN
gs-4060	866	21	.	.	PUNCT
gs-4060	867	1	first	first	ADJ
gs-4060	867	2	-	-	PUNCT
gs-4060	867	3	line	line	NOUN
gs-4060	867	4	crizotinib	crizotinib	NOUN
gs-4060	867	5	versus	versus	ADP
gs-4060	867	6	chemotherapy	chemotherapy	NOUN
gs-4060	867	7	in	in	ADP
gs-4060	867	8	alk	alk	ADJ
gs-4060	867	9	-	-	PUNCT
gs-4060	867	10	positive	positive	ADJ
gs-4060	867	11	lung	lung	NOUN
gs-4060	867	12	cancer	cancer	NOUN
gs-4060	867	13	.	.	PUNCT
gs-4060	868	1	n	n	PROPN
gs-4060	868	2	engl	engl	PROPN
gs-4060	868	3	j	j	PROPN
gs-4060	868	4	med	med	PROPN
gs-4060	868	5	.	.	PUNCT
gs-4060	869	1	2014;371(23):2167	2014;371(23):2167	NUM
gs-4060	869	2	-	-	SYM
gs-4060	869	3	77	77	NUM
gs-4060	869	4	.	.	PUNCT
gs-4060	870	1	39.garon	39.garon	NUM
gs-4060	870	2	eb	eb	PROPN
gs-4060	870	3	,	,	PUNCT
gs-4060	870	4	hellmann	hellmann	PROPN
gs-4060	870	5	md	md	PROPN
gs-4060	870	6	,	,	PUNCT
gs-4060	870	7	rizvi	rizvi	ADJ
gs-4060	870	8	na	na	ADP
gs-4060	870	9	,	,	PUNCT
gs-4060	870	10	carcereny	carcereny	NOUN
gs-4060	870	11	e	e	PROPN
gs-4060	870	12	,	,	PUNCT
gs-4060	870	13	leighl	leighl	PROPN
gs-4060	870	14	nb	nb	PROPN
gs-4060	870	15	,	,	PUNCT
gs-4060	870	16	ahn	ahn	PROPN
gs-4060	870	17	mj	mj	PROPN
gs-4060	870	18	,	,	PUNCT
gs-4060	870	19	et	et	PROPN
gs-4060	870	20	al	al	PROPN
gs-4060	870	21	.	.	PROPN
gs-4060	871	1	five	five	NUM
gs-4060	871	2	-	-	PUNCT
gs-4060	871	3	year	year	NOUN
gs-4060	871	4	overall	overall	ADJ
gs-4060	871	5	survival	survival	NOUN
gs-4060	871	6	for	for	ADP
gs-4060	871	7	patients	patient	NOUN
gs-4060	871	8	with	with	ADP
gs-4060	871	9	advanced	advanced	ADJ
gs-4060	871	10	non	non	ADJ
gs-4060	871	11	-	-	ADJ
gs-4060	871	12	small	small	ADJ
gs-4060	871	13	-	-	PUNCT
gs-4060	871	14	cell	cell	NOUN
gs-4060	871	15	lung	lung	NOUN
gs-4060	871	16	cancer	cancer	NOUN
gs-4060	871	17	treated	treat	VERB
gs-4060	871	18	with	with	ADP
gs-4060	871	19	pembrolizumab	pembrolizumab	NOUN
gs-4060	871	20	:	:	PUNCT
gs-4060	871	21	results	result	NOUN
gs-4060	871	22	from	from	ADP
gs-4060	871	23	the	the	DET
gs-4060	871	24	phase	phase	NOUN
gs-4060	871	25	i	i	PRON
gs-4060	871	26	keynote-001	keynote-001	PROPN
gs-4060	871	27	study	study	NOUN
gs-4060	871	28	.	.	PUNCT
gs-4060	872	1	j	j	PROPN
gs-4060	872	2	clin	clin	PROPN
gs-4060	872	3	oncol	oncol	PROPN
gs-4060	872	4	.	.	PUNCT
gs-4060	873	1	2019;37(28):2518	2019;37(28):2518	NUM
gs-4060	873	2	-	-	SYM
gs-4060	873	3	27	27	NUM
gs-4060	873	4	.	.	PUNCT
gs-4060	874	1	40.postow	40.postow	NUM
gs-4060	874	2	ma	ma	PROPN
gs-4060	874	3	,	,	PUNCT
gs-4060	874	4	sidlow	sidlow	NOUN
gs-4060	874	5	r	r	PROPN
gs-4060	874	6	,	,	PUNCT
gs-4060	874	7	hellmann	hellmann	PROPN
gs-4060	874	8	md	md	PROPN
gs-4060	874	9	.	.	PROPN
gs-4060	874	10	immune	immune	NOUN
gs-4060	874	11	-	-	PUNCT
gs-4060	874	12	related	relate	VERB
gs-4060	874	13	adverse	adverse	ADJ
gs-4060	874	14	events	event	NOUN
gs-4060	874	15	associated	associate	VERB
gs-4060	874	16	with	with	ADP
gs-4060	874	17	immune	immune	ADJ
gs-4060	874	18	checkpoint	checkpoint	NOUN
gs-4060	874	19	blockade	blockade	NOUN
gs-4060	874	20	.	.	PUNCT
gs-4060	875	1	n	n	PROPN
gs-4060	875	2	engl	engl	PROPN
gs-4060	875	3	j	j	PROPN
gs-4060	875	4	med	med	PROPN
gs-4060	875	5	.	.	PUNCT
gs-4060	876	1	2018;378(2):158	2018;378(2):158	NUM
gs-4060	876	2	-	-	SYM
gs-4060	876	3	68	68	NUM
gs-4060	876	4	.	.	PUNCT
gs-4060	877	1	41.brahmer	41.brahmer	NUM
gs-4060	878	1	jr	jr	NOUN
gs-4060	878	2	,	,	PUNCT
gs-4060	878	3	lacchetti	lacchetti	VERB
gs-4060	878	4	c	c	X
gs-4060	878	5	,	,	PUNCT
gs-4060	878	6	schneider	schneider	NOUN
gs-4060	878	7	bj	bj	PROPN
gs-4060	878	8	,	,	PUNCT
gs-4060	878	9	atkins	atkins	PROPN
gs-4060	878	10	mb	mb	PROPN
gs-4060	878	11	,	,	PUNCT
gs-4060	878	12	brassil	brassil	NOUN
gs-4060	878	13	kj	kj	PROPN
gs-4060	878	14	,	,	PUNCT
gs-4060	878	15	caterino	caterino	PROPN
gs-4060	878	16	jm	jm	PROPN
gs-4060	878	17	,	,	PUNCT
gs-4060	879	1	et	et	PROPN
gs-4060	879	2	al	al	PROPN
gs-4060	879	3	.	.	PUNCT
gs-4060	879	4	management	management	NOUN
gs-4060	879	5	of	of	ADP
gs-4060	879	6	immune	immune	NOUN
gs-4060	879	7	-	-	PUNCT
gs-4060	879	8	related	relate	VERB
gs-4060	879	9	adverse	adverse	ADJ
gs-4060	879	10	events	event	NOUN
gs-4060	879	11	in	in	ADP
gs-4060	879	12	patients	patient	NOUN
gs-4060	879	13	treated	treat	VERB
gs-4060	879	14	with	with	ADP
gs-4060	879	15	immune	immune	ADJ
gs-4060	879	16	checkpoint	checkpoint	NOUN
gs-4060	879	17	inhibitor	inhibitor	NOUN
gs-4060	879	18	therapy	therapy	NOUN
gs-4060	879	19	:	:	PUNCT
gs-4060	879	20	american	american	ADJ
gs-4060	879	21	society	society	NOUN
gs-4060	879	22	of	of	ADP
gs-4060	879	23	clinical	clinical	ADJ
gs-4060	879	24	oncology	oncology	NOUN
gs-4060	879	25	clinical	clinical	ADJ
gs-4060	879	26	practice	practice	NOUN
gs-4060	879	27	guideline	guideline	NOUN
gs-4060	879	28	.	.	PUNCT
gs-4060	880	1	j	j	PROPN
gs-4060	880	2	clin	clin	PROPN
gs-4060	880	3	oncol	oncol	PROPN
gs-4060	880	4	.	.	PUNCT
gs-4060	881	1	2018;36(17):1714	2018;36(17):1714	X
gs-4060	881	2	-	-	SYM
gs-4060	881	3	68	68	NUM
gs-4060	881	4	.	.	PUNCT
gs-4060	882	1	42.lee	42.lee	PROPN
gs-4060	882	2	dw	dw	PROPN
gs-4060	882	3	,	,	PUNCT
gs-4060	882	4	santomasso	santomasso	ADJ
gs-4060	882	5	bd	bd	PROPN
gs-4060	882	6	,	,	PUNCT
gs-4060	882	7	locke	locke	PROPN
gs-4060	882	8	fl	fl	PROPN
gs-4060	882	9	,	,	PUNCT
gs-4060	882	10	ghobadi	ghobadi	VERB
gs-4060	882	11	a	a	PRON
gs-4060	882	12	,	,	PUNCT
gs-4060	882	13	turtle	turtle	NOUN
gs-4060	882	14	cj	cj	NUM
gs-4060	882	15	,	,	PUNCT
gs-4060	882	16	brudno	brudno	PROPN
gs-4060	882	17	jn	jn	PROPN
gs-4060	882	18	,	,	PUNCT
gs-4060	882	19	et	et	PROPN
gs-4060	882	20	al	al	PROPN
gs-4060	882	21	.	.	PROPN
gs-4060	883	1	astct	astct	PROPN
gs-4060	883	2	consensus	consensus	NOUN
gs-4060	883	3	grading	grade	VERB
gs-4060	883	4	for	for	ADP
gs-4060	883	5	cytokine	cytokine	ADJ
gs-4060	883	6	release	release	NOUN
gs-4060	883	7	syndrome	syndrome	NOUN
gs-4060	883	8	and	and	CCONJ
gs-4060	883	9	neurologic	neurologic	ADJ
gs-4060	883	10	toxicity	toxicity	NOUN
gs-4060	883	11	associated	associate	VERB
gs-4060	883	12	with	with	ADP
gs-4060	883	13	immune	immune	ADJ
gs-4060	883	14	effector	effector	NOUN
gs-4060	883	15	cells	cell	NOUN
gs-4060	883	16	.	.	PUNCT
gs-4060	884	1	biol	biol	PROPN
gs-4060	884	2	blood	blood	NOUN
gs-4060	884	3	marrow	marrow	PROPN
gs-4060	884	4	transplant	transplant	NOUN
gs-4060	884	5	.	.	PUNCT
gs-4060	885	1	2019;25(4):625	2019;25(4):625	NUM
gs-4060	885	2	-	-	SYM
gs-4060	885	3	38	38	NUM
gs-4060	885	4	.	.	PUNCT
gs-4060	886	1	43.neelapu	43.neelapu	NUM
gs-4060	886	2	ss	ss	NOUN
gs-4060	886	3	.	.	PUNCT
gs-4060	887	1	managing	manage	VERB
gs-4060	887	2	the	the	DET
gs-4060	887	3	toxicities	toxicity	NOUN
gs-4060	887	4	of	of	ADP
gs-4060	887	5	car	car	NOUN
gs-4060	887	6	t	t	NOUN
gs-4060	887	7	-	-	PUNCT
gs-4060	887	8	cell	cell	NOUN
gs-4060	887	9	therapy	therapy	NOUN
gs-4060	887	10	.	.	PUNCT
gs-4060	888	1	hematological	hematological	ADJ
gs-4060	888	2	oncology	oncology	NOUN
gs-4060	888	3	.	.	PUNCT
gs-4060	889	1	2019;37(s1):48	2019;37(s1):48	NUM
gs-4060	889	2	-	-	SYM
gs-4060	889	3	52	52	NUM
gs-4060	889	4	.	.	PUNCT
gs-4060	890	1	44.ott	44.ott	PROPN
gs-4060	890	2	pa	pa	PROPN
gs-4060	890	3	,	,	PUNCT
gs-4060	890	4	hu	hu	PROPN
gs-4060	891	1	z	z	X
gs-4060	891	2	,	,	PUNCT
gs-4060	891	3	keskin	keskin	PROPN
gs-4060	891	4	db	db	PROPN
gs-4060	891	5	,	,	PUNCT
gs-4060	891	6	shukla	shukla	PROPN
gs-4060	891	7	sa	sa	PROPN
gs-4060	891	8	,	,	PUNCT
gs-4060	891	9	sun	sun	PROPN
gs-4060	891	10	j	j	PROPN
gs-4060	891	11	,	,	PUNCT
gs-4060	891	12	bozym	bozym	ADJ
gs-4060	891	13	dj	dj	NOUN
gs-4060	891	14	,	,	PUNCT
gs-4060	891	15	et	et	PROPN
gs-4060	891	16	al	al	PROPN
gs-4060	891	17	.	.	PUNCT
gs-4060	892	1	an	an	DET
gs-4060	892	2	immunogenic	immunogenic	ADJ
gs-4060	892	3	personal	personal	ADJ
gs-4060	892	4	neoantigen	neoantigen	NOUN
gs-4060	892	5	vaccine	vaccine	NOUN
gs-4060	892	6	for	for	ADP
gs-4060	892	7	patients	patient	NOUN
gs-4060	892	8	with	with	ADP
gs-4060	892	9	melanoma	melanoma	NOUN
gs-4060	892	10	.	.	PUNCT
gs-4060	893	1	nature	nature	NOUN
gs-4060	893	2	.	.	PUNCT
gs-4060	894	1	2017;547(7662):217	2017;547(7662):217	NUM
gs-4060	894	2	-	-	SYM
gs-4060	894	3	21	21	NUM
gs-4060	894	4	.	.	PUNCT
gs-4060	895	1	45.sahin	45.sahin	NUM
gs-4060	895	2	u	u	NOUN
gs-4060	895	3	,	,	PUNCT
gs-4060	895	4	derhovanessian	derhovanessian	PROPN
gs-4060	895	5	e	e	PROPN
gs-4060	895	6	,	,	PUNCT
gs-4060	895	7	miller	miller	PROPN
gs-4060	895	8	m	m	PROPN
gs-4060	895	9	,	,	PUNCT
gs-4060	895	10	kloke	kloke	PROPN
gs-4060	895	11	bp	bp	PROPN
gs-4060	895	12	,	,	PUNCT
gs-4060	895	13	simon	simon	PROPN
gs-4060	895	14	p	p	PROPN
gs-4060	895	15	,	,	PUNCT
gs-4060	895	16	löwer	löwer	NOUN
gs-4060	895	17	m	m	PROPN
gs-4060	895	18	,	,	PUNCT
gs-4060	895	19	et	et	PROPN
gs-4060	895	20	al	al	PROPN
gs-4060	895	21	.	.	PROPN
gs-4060	896	1	personalized	personalize	VERB
gs-4060	896	2	rna	rna	PROPN
gs-4060	896	3	mutanome	mutanome	NOUN
gs-4060	896	4	vaccines	vaccine	NOUN
gs-4060	896	5	mobilize	mobilize	VERB
gs-4060	896	6	poly	poly	ADJ
gs-4060	896	7	-	-	PUNCT
gs-4060	896	8	specific	specific	ADJ
gs-4060	896	9	therapeutic	therapeutic	ADJ
gs-4060	896	10	immunity	immunity	NOUN
gs-4060	896	11	against	against	ADP
gs-4060	896	12	cancer	cancer	NOUN
gs-4060	896	13	.	.	PUNCT
gs-4060	897	1	nature	nature	NOUN
gs-4060	897	2	.	.	PUNCT
gs-4060	898	1	2017;547(7662):222	2017;547(7662):222	NUM
gs-4060	898	2	-	-	SYM
gs-4060	898	3	6	6	NUM
gs-4060	898	4	.	.	PUNCT
gs-4060	899	1	46.tumeh	46.tumeh	NUM
gs-4060	899	2	pc	pc	NOUN
gs-4060	899	3	,	,	PUNCT
gs-4060	899	4	harview	harview	NOUN
gs-4060	899	5	cl	cl	NOUN
gs-4060	899	6	,	,	PUNCT
gs-4060	899	7	yearley	yearley	NOUN
gs-4060	899	8	jh	jh	PROPN
gs-4060	899	9	,	,	PUNCT
gs-4060	899	10	shintaku	shintaku	PROPN
gs-4060	899	11	ip	ip	PROPN
gs-4060	899	12	,	,	PUNCT
gs-4060	899	13	taylor	taylor	PROPN
gs-4060	899	14	ej	ej	PROPN
gs-4060	899	15	,	,	PUNCT
gs-4060	899	16	robert	robert	PROPN
gs-4060	899	17	l	l	PROPN
gs-4060	899	18	,	,	PUNCT
gs-4060	899	19	et	et	PROPN
gs-4060	899	20	al	al	PROPN
gs-4060	899	21	.	.	PROPN
gs-4060	899	22	pd-1	pd-1	ADP
gs-4060	899	23	blockade	blockade	NOUN
gs-4060	899	24	induces	induce	VERB
gs-4060	899	25	responses	response	NOUN
gs-4060	899	26	by	by	ADP
gs-4060	899	27	inhibiting	inhibit	VERB
gs-4060	899	28	adaptive	adaptive	ADJ
gs-4060	899	29	immune	immune	ADJ
gs-4060	899	30	resistance	resistance	NOUN
gs-4060	899	31	.	.	PUNCT
gs-4060	900	1	nature	nature	NOUN
gs-4060	900	2	.	.	PUNCT
gs-4060	901	1	2014;515(7528):568	2014;515(7528):568	NUM
gs-4060	901	2	-	-	SYM
gs-4060	901	3	71	71	NUM
gs-4060	901	4	.	.	PUNCT
gs-4060	902	1	47.ribas	47.ribas	NUM
gs-4060	902	2	a	a	DET
gs-4060	902	3	,	,	PUNCT
gs-4060	902	4	wolchok	wolchok	PROPN
gs-4060	902	5	jd	jd	PROPN
gs-4060	902	6	.	.	PUNCT
gs-4060	902	7	cancer	cancer	NOUN
gs-4060	902	8	immunotherapy	immunotherapy	NOUN
gs-4060	902	9	using	use	VERB
gs-4060	902	10	checkpoint	checkpoint	NOUN
gs-4060	902	11	blockade	blockade	NOUN
gs-4060	902	12	.	.	PUNCT
gs-4060	903	1	science	science	NOUN
gs-4060	903	2	.	.	PUNCT
gs-4060	904	1	2018;359(6382):1350	2018;359(6382):1350	NUM
gs-4060	904	2	-	-	SYM
gs-4060	904	3	5	5	NUM
gs-4060	904	4	.	.	PUNCT
gs-4060	905	1	48.zou	48.zou	PROPN
gs-4060	905	2	w	w	PROPN
gs-4060	905	3	,	,	PUNCT
gs-4060	905	4	wolchok	wolchok	PROPN
gs-4060	905	5	jd	jd	PROPN
gs-4060	905	6	,	,	PUNCT
gs-4060	905	7	chen	chen	PROPN
gs-4060	905	8	l.	l.	PROPN
gs-4060	905	9	pd	pd	PROPN
gs-4060	905	10	-	-	PROPN
gs-4060	905	11	l1	l1	PROPN
gs-4060	905	12	(	(	PUNCT
gs-4060	905	13	b7	b7	PROPN
gs-4060	905	14	-	-	PUNCT
gs-4060	905	15	h1	h1	PROPN
gs-4060	905	16	)	)	PUNCT
gs-4060	905	17	and	and	CCONJ
gs-4060	905	18	pd-1	pd-1	VERB
gs-4060	905	19	pathway	pathway	NOUN
gs-4060	905	20	blockade	blockade	NOUN
gs-4060	905	21	for	for	ADP
gs-4060	905	22	cancer	cancer	NOUN
gs-4060	905	23	therapy	therapy	NOUN
gs-4060	905	24	:	:	PUNCT
gs-4060	905	25	mechanisms	mechanism	NOUN
gs-4060	905	26	,	,	PUNCT
gs-4060	905	27	response	response	NOUN
gs-4060	905	28	biomarkers	biomarker	NOUN
gs-4060	905	29	,	,	PUNCT
gs-4060	905	30	and	and	CCONJ
gs-4060	905	31	combinations	combination	NOUN
gs-4060	905	32	.	.	PUNCT
gs-4060	906	1	sci	sci	PROPN
gs-4060	906	2	transl	transl	PROPN
gs-4060	906	3	med	med	PROPN
gs-4060	906	4	.	.	PUNCT
gs-4060	907	1	2016;8(328):328rv4	2016;8(328):328rv4	NUM
gs-4060	907	2	.	.	PUNCT
gs-4060	908	1	49.sharma	49.sharma	NUM
gs-4060	909	1	p	p	X
gs-4060	909	2	,	,	PUNCT
gs-4060	909	3	hu	hu	PROPN
gs-4060	909	4	-	-	PROPN
gs-4060	909	5	lieskovan	lieskovan	PROPN
gs-4060	909	6	s	s	PROPN
gs-4060	909	7	,	,	PUNCT
gs-4060	909	8	wargo	wargo	PROPN
gs-4060	909	9	ja	ja	PROPN
gs-4060	909	10	,	,	PUNCT
gs-4060	909	11	ribas	ribas	PROPN
gs-4060	909	12	a.	a.	PROPN
gs-4060	909	13	primary	primary	NOUN
gs-4060	909	14	,	,	PUNCT
gs-4060	909	15	adaptive	adaptive	ADJ
gs-4060	909	16	,	,	PUNCT
gs-4060	909	17	and	and	CCONJ
gs-4060	909	18	acquired	acquire	VERB
gs-4060	909	19	resistance	resistance	NOUN
gs-4060	909	20	to	to	ADP
gs-4060	909	21	cancer	cancer	NOUN
gs-4060	909	22	immunotherapy	immunotherapy	NOUN
gs-4060	909	23	.	.	PUNCT
gs-4060	910	1	cell	cell	NOUN
gs-4060	910	2	.	.	PUNCT
gs-4060	911	1	2017;168(4):707	2017;168(4):707	NUM
gs-4060	911	2	-	-	SYM
gs-4060	911	3	23	23	NUM
gs-4060	911	4	.	.	PUNCT
gs-4060	912	1	50.gajewski	50.gajewski	NUM
gs-4060	912	2	tf	tf	INTJ
gs-4060	912	3	,	,	PUNCT
gs-4060	912	4	schreiber	schreiber	PROPN
gs-4060	912	5	h	h	PROPN
gs-4060	912	6	,	,	PUNCT
gs-4060	912	7	fu	fu	PROPN
gs-4060	912	8	yx	yx	PROPN
gs-4060	912	9	.	.	PROPN
gs-4060	912	10	innate	innate	ADJ
gs-4060	912	11	and	and	CCONJ
gs-4060	912	12	adaptive	adaptive	ADJ
gs-4060	912	13	immune	immune	ADJ
gs-4060	912	14	cells	cell	NOUN
gs-4060	912	15	in	in	ADP
gs-4060	912	16	the	the	DET
gs-4060	912	17	tumor	tumor	NOUN
gs-4060	912	18	microenvironment	microenvironment	NOUN
gs-4060	912	19	.	.	PUNCT
gs-4060	913	1	nat	nat	PROPN
gs-4060	913	2	immunol	immunol	NOUN
gs-4060	913	3	.	.	PUNCT
gs-4060	914	1	2013;14(10):1014	2013;14(10):1014	NUM
gs-4060	914	2	-	-	SYM
gs-4060	914	3	22	22	NUM
gs-4060	914	4	.	.	PUNCT
gs-4060	915	1	51.joyce	51.joyce	NUM
gs-4060	915	2	ja	ja	PROPN
gs-4060	915	3	,	,	PUNCT
gs-4060	915	4	fearon	fearon	PROPN
gs-4060	915	5	dt	dt	PROPN
gs-4060	915	6	.	.	PUNCT
gs-4060	916	1	t	t	PROPN
gs-4060	916	2	cell	cell	NOUN
gs-4060	916	3	exclusion	exclusion	NOUN
gs-4060	916	4	,	,	PUNCT
gs-4060	916	5	immune	immune	ADJ
gs-4060	916	6	privilege	privilege	NOUN
gs-4060	916	7	,	,	PUNCT
gs-4060	916	8	and	and	CCONJ
gs-4060	916	9	the	the	DET
gs-4060	916	10	tumor	tumor	NOUN
gs-4060	916	11	microenvironment	microenvironment	NOUN
gs-4060	916	12	.	.	PUNCT
gs-4060	917	1	science	science	NOUN
gs-4060	917	2	.	.	PUNCT
gs-4060	918	1	2015;348(6230):74	2015;348(6230):74	X
gs-4060	918	2	-	-	PUNCT
gs-4060	918	3	80	80	NUM
gs-4060	918	4	.	.	PUNCT
gs-4060	919	1	52.zitvogel	52.zitvogel	NUM
gs-4060	919	2	l	l	NOUN
gs-4060	919	3	,	,	PUNCT
gs-4060	919	4	ayyoub	ayyoub	PROPN
gs-4060	919	5	m	m	PROPN
gs-4060	919	6	,	,	PUNCT
gs-4060	919	7	routy	routy	PROPN
gs-4060	919	8	b	b	PROPN
gs-4060	919	9	,	,	PUNCT
gs-4060	919	10	kroemer	kroemer	PROPN
gs-4060	919	11	g.	g.	PROPN
gs-4060	919	12	microbiome	microbiome	PROPN
gs-4060	919	13	and	and	CCONJ
gs-4060	919	14	anticancer	anticancer	NOUN
gs-4060	919	15	immunosurveillance	immunosurveillance	NOUN
gs-4060	919	16	.	.	PUNCT
gs-4060	920	1	cell	cell	NOUN
gs-4060	920	2	.	.	PUNCT
gs-4060	921	1	2016;165(2):276	2016;165(2):276	NUM
gs-4060	921	2	-	-	SYM
gs-4060	921	3	87	87	NUM
gs-4060	921	4	.	.	PUNCT
gs-4060	922	1	53.gopalakrishnan	53.gopalakrishnan	NUM
gs-4060	922	2	v	v	NOUN
gs-4060	922	3	,	,	PUNCT
gs-4060	922	4	spencer	spencer	PROPN
gs-4060	922	5	cn	cn	PROPN
gs-4060	922	6	,	,	PUNCT
gs-4060	922	7	nezi	nezi	PROPN
gs-4060	922	8	l	l	PROPN
gs-4060	922	9	,	,	PUNCT
gs-4060	922	10	reuben	reuben	PROPN
gs-4060	922	11	a	a	PRON
gs-4060	922	12	,	,	PUNCT
gs-4060	922	13	andrews	andrews	PROPN
gs-4060	922	14	mc	mc	PROPN
gs-4060	922	15	,	,	PUNCT
gs-4060	922	16	karpinets	karpinet	NOUN
gs-4060	922	17	tv	tv	NOUN
gs-4060	922	18	,	,	PUNCT
gs-4060	922	19	et	et	PROPN
gs-4060	922	20	al	al	PROPN
gs-4060	922	21	.	.	PUNCT
gs-4060	923	1	gut	gut	VERB
gs-4060	923	2	microbiome	microbiome	ADJ
gs-4060	923	3	modulates	modulate	NOUN
gs-4060	923	4	response	response	NOUN
gs-4060	923	5	to	to	ADP
gs-4060	923	6	anti	anti	ADJ
gs-4060	923	7	-	-	ADJ
gs-4060	923	8	pd-1	pd-1	ADJ
gs-4060	923	9	immunotherapy	immunotherapy	NOUN
gs-4060	923	10	in	in	ADP
gs-4060	923	11	melanoma	melanoma	NOUN
gs-4060	923	12	patients	patient	NOUN
gs-4060	923	13	.	.	PUNCT
gs-4060	924	1	science	science	NOUN
gs-4060	924	2	.	.	PUNCT
gs-4060	925	1	2018;359(6371):97	2018;359(6371):97	NUM
gs-4060	925	2	-	-	SYM
gs-4060	925	3	103	103	NUM
gs-4060	925	4	.	.	PUNCT
gs-4060	926	1	georgian	georgian	NOUN
gs-4060	926	2	scientists/	scientists/	NUM
gs-4060	926	3	.	.	PUNCT
gs-4060	927	1	7	7	NUM
gs-4060	927	2	n	n	PRON
gs-4060	927	3	3	3	NUM
gs-4060	927	4	,	,	PUNCT
gs-4060	927	5	2025	2025	NUM
gs-4060	927	6	607	607	NUM
gs-4060	927	7	54.routy	54.routy	NUM
gs-4060	927	8	b	b	PROPN
gs-4060	927	9	,	,	PUNCT
gs-4060	927	10	le	le	X
gs-4060	927	11	chatelier	chatelier	ADV
gs-4060	927	12	e	e	PROPN
gs-4060	927	13	,	,	PUNCT
gs-4060	927	14	derosa	derosa	PROPN
gs-4060	927	15	l	l	PROPN
gs-4060	927	16	,	,	PUNCT
gs-4060	927	17	duong	duong	PROPN
gs-4060	927	18	cpm	cpm	PROPN
gs-4060	927	19	,	,	PUNCT
gs-4060	927	20	alou	alou	PROPN
gs-4060	927	21	mt	mt	PROPN
gs-4060	927	22	,	,	PUNCT
gs-4060	927	23	daillère	daillère	NOUN
gs-4060	927	24	r	r	NOUN
gs-4060	927	25	,	,	PUNCT
gs-4060	927	26	et	et	PROPN
gs-4060	927	27	al	al	PROPN
gs-4060	927	28	.	.	PUNCT
gs-4060	928	1	gut	gut	NOUN
gs-4060	928	2	microbiome	microbiome	NOUN
gs-4060	928	3	influences	influence	NOUN
gs-4060	928	4	efficacy	efficacy	NOUN
gs-4060	928	5	of	of	ADP
gs-4060	928	6	pd-1	pd-1	ADV
gs-4060	928	7	-	-	PUNCT
gs-4060	928	8	based	base	VERB
gs-4060	928	9	immunotherapy	immunotherapy	NOUN
gs-4060	928	10	against	against	ADP
gs-4060	928	11	epithelial	epithelial	ADJ
gs-4060	928	12	tumors	tumor	NOUN
gs-4060	928	13	.	.	PUNCT
gs-4060	929	1	science	science	NOUN
gs-4060	929	2	.	.	PUNCT
gs-4060	930	1	2018;359(6371):91	2018;359(6371):91	NUM
gs-4060	930	2	-	-	SYM
gs-4060	930	3	7	7	NUM
gs-4060	930	4	.	.	PUNCT
gs-4060	931	1	55.aphkhazava	55.aphkhazava	NUM
gs-4060	931	2	,	,	PUNCT
gs-4060	931	3	d.	d.	PROPN
gs-4060	931	4	,	,	PUNCT
gs-4060	931	5	sulashvili	sulashvili	NOUN
gs-4060	931	6	,	,	PUNCT
gs-4060	931	7	n.	n.	NOUN
gs-4060	931	8	,	,	PUNCT
gs-4060	931	9	tupinashvili	tupinashvili	NOUN
gs-4060	931	10	,	,	PUNCT
gs-4060	931	11	t.	t.	PROPN
gs-4060	931	12	,	,	PUNCT
gs-4060	931	13	&	&	CCONJ
gs-4060	931	14	nozadze	nozadze	NOUN
gs-4060	931	15	,	,	PUNCT
gs-4060	931	16	m.	m.	NOUN
gs-4060	931	17	(	(	PUNCT
gs-4060	931	18	2024	2024	NUM
gs-4060	931	19	)	)	PUNCT
gs-4060	931	20	.	.	PUNCT
gs-4060	932	1	dynamic	dynamic	ADJ
gs-4060	932	2	cellular	cellular	ADJ
gs-4060	932	3	equilibrium	equilibrium	NOUN
gs-4060	932	4	theory	theory	NOUN
gs-4060	932	5	of	of	ADP
gs-4060	932	6	aging	aging	NOUN
gs-4060	932	7	:	:	PUNCT
gs-4060	932	8	integrating	integrate	VERB
gs-4060	932	9	maintenance	maintenance	NOUN
gs-4060	932	10	and	and	CCONJ
gs-4060	932	11	accumulation	accumulation	NOUN
gs-4060	932	12	in	in	ADP
gs-4060	932	13	the	the	DET
gs-4060	932	14	aging	age	VERB
gs-4060	932	15	process	process	NOUN
gs-4060	932	16	.	.	PUNCT
gs-4060	933	1	scientific	scientific	ADJ
gs-4060	933	2	journal	journal	NOUN
gs-4060	933	3	„	„	PUNCT
gs-4060	933	4	spectri	spectri	NOUN
gs-4060	933	5	“	"	PUNCT
gs-4060	933	6	,	,	PUNCT
gs-4060	933	7	8(2	8(2	NUM
gs-4060	933	8	)	)	PUNCT
gs-4060	933	9	.	.	PUNCT
gs-4060	934	1	https://doi.org/10.52340/spectri.2023.08.02.03	https://doi.org/10.52340/spectri.2023.08.02.03	PROPN
gs-4060	934	2	56.sulashvili	56.sulashvili	NUM
gs-4060	934	3	n	n	CCONJ
gs-4060	934	4	,	,	PUNCT
gs-4060	934	5	jadhav	jadhav	PROPN
gs-4060	934	6	rd	rd	PROPN
gs-4060	934	7	,	,	PUNCT
gs-4060	934	8	beglaryan	beglaryan	PROPN
gs-4060	934	9	m	m	PROPN
gs-4060	934	10	,	,	PUNCT
gs-4060	934	11	gabunia	gabunia	NOUN
gs-4060	934	12	l	l	NOUN
gs-4060	934	13	,	,	PUNCT
gs-4060	934	14	gorgaslidze	gorgaslidze	ADJ
gs-4060	934	15	n	n	CCONJ
gs-4060	934	16	,	,	PUNCT
gs-4060	934	17	alavidze	alavidze	PROPN
gs-4060	934	18	n	n	CCONJ
gs-4060	934	19	,	,	PUNCT
gs-4060	934	20	et	et	PROPN
gs-4060	934	21	al	al	PROPN
gs-4060	934	22	.	.	PUNCT
gs-4060	935	1	the	the	DET
gs-4060	935	2	scientific	scientific	ADJ
gs-4060	935	3	discussion	discussion	NOUN
gs-4060	935	4	of	of	ADP
gs-4060	935	5	key	key	ADJ
gs-4060	935	6	issue	issue	NOUN
gs-4060	935	7	aspects	aspect	NOUN
gs-4060	935	8	of	of	ADP
gs-4060	935	9	immunopathogenesis	immunopathogenesis	NOUN
gs-4060	935	10	and	and	CCONJ
gs-4060	935	11	pharmacological	pharmacological	NOUN
gs-4060	935	12	properties	property	NOUN
gs-4060	935	13	and	and	CCONJ
gs-4060	935	14	profiles	profile	NOUN
gs-4060	935	15	in	in	ADP
gs-4060	935	16	relation	relation	NOUN
gs-4060	935	17	to	to	ADP
gs-4060	935	18	adverse	adverse	ADJ
gs-4060	935	19	drug	drug	NOUN
gs-4060	935	20	reactions	reaction	NOUN
gs-4060	935	21	challenges	challenge	NOUN
gs-4060	935	22	,	,	PUNCT
gs-4060	935	23	focus	focus	VERB
gs-4060	935	24	on	on	ADP
gs-4060	935	25	multidimensional	multidimensional	ADJ
gs-4060	935	26	drug	drug	NOUN
gs-4060	935	27	-	-	PUNCT
gs-4060	935	28	induced	induce	VERB
gs-4060	935	29	eosinophilia	eosinophilia	NOUN
gs-4060	935	30	and	and	CCONJ
gs-4060	935	31	systemic	systemic	ADJ
gs-4060	935	32	syndrome	syndrome	NOUN
gs-4060	935	33	.	.	PUNCT
gs-4060	936	1	gs	gs	X
gs-4060	937	1	[	[	X
gs-4060	937	2	internet	internet	NOUN
gs-4060	937	3	]	]	X
gs-4060	937	4	.	.	PUNCT
gs-4060	938	1	2025	2025	NUM
gs-4060	938	2	jul	jul	NOUN
gs-4060	938	3	.	.	PROPN
gs-4060	938	4	11	11	NUM
gs-4060	939	1	[	[	X
gs-4060	939	2	cited	cite	VERB
gs-4060	939	3	2025	2025	NUM
gs-4060	939	4	jul	jul	PROPN
gs-4060	939	5	.	.	PUNCT
gs-4060	940	1	12];7(3):141	12];7(3):141	NUM
gs-4060	940	2	-	-	SYM
gs-4060	940	3	79	79	NUM
gs-4060	940	4	.	.	PUNCT
gs-4060	941	1	available	available	ADJ
gs-4060	941	2	from	from	ADP
gs-4060	941	3	:	:	PUNCT
gs-4060	941	4	https://journals.4science.ge/index.php/gs/article/view/3919	https://journals.4science.ge/index.php/gs/article/view/3919	NOUN
gs-4060	941	5	.	.	NOUN
gs-4060	941	6	57.sulashvili	57.sulashvili	NUM
gs-4060	941	7	n	n	CCONJ
gs-4060	941	8	,	,	PUNCT
gs-4060	941	9	fernando	fernando	PROPN
gs-4060	941	10	s	s	PROPN
gs-4060	941	11	,	,	PUNCT
gs-4060	941	12	el	el	PROPN
gs-4060	941	13	-	-	PUNCT
gs-4060	941	14	hakeem	hakeem	PROPN
gs-4060	941	15	a	a	PRON
gs-4060	941	16	,	,	PUNCT
gs-4060	941	17	gabunia	gabunia	NOUN
gs-4060	941	18	l	l	NOUN
gs-4060	941	19	,	,	PUNCT
gs-4060	941	20	gorgaslidze	gorgaslidze	ADJ
gs-4060	941	21	n	n	CCONJ
gs-4060	941	22	,	,	PUNCT
gs-4060	941	23	beglaryan	beglaryan	PROPN
gs-4060	941	24	m	m	PROPN
gs-4060	941	25	,	,	PUNCT
gs-4060	941	26	et	et	PROPN
gs-4060	941	27	al	al	PROPN
gs-4060	941	28	.	.	PROPN
gs-4060	942	1	closedloop	closedloop	PROPN
gs-4060	942	2	cardiopulmonary	cardiopulmonary	ADJ
gs-4060	942	3	bypass	bypass	NOUN
gs-4060	942	4	systems	system	NOUN
gs-4060	942	5	with	with	ADP
gs-4060	942	6	real	real	ADJ
gs-4060	942	7	-	-	PUNCT
gs-4060	942	8	time	time	NOUN
gs-4060	942	9	monitoring	monitoring	NOUN
gs-4060	942	10	and	and	CCONJ
gs-4060	942	11	pharmacotherapy	pharmacotherapy	NOUN
gs-4060	942	12	strategies	strategy	NOUN
gs-4060	942	13	:	:	PUNCT
gs-4060	942	14	innovations	innovation	NOUN
gs-4060	942	15	,	,	PUNCT
gs-4060	942	16	outcomes	outcome	NOUN
gs-4060	942	17	,	,	PUNCT
gs-4060	942	18	clinical	clinical	ADJ
gs-4060	942	19	impact	impact	NOUN
gs-4060	942	20	and	and	CCONJ
gs-4060	942	21	future	future	ADJ
gs-4060	942	22	directions	direction	NOUN
gs-4060	942	23	in	in	ADP
gs-4060	942	24	general	general	ADJ
gs-4060	942	25	.	.	PUNCT
gs-4060	943	1	gs	gs	PROPN
gs-4060	944	1	[	[	X
gs-4060	944	2	internet	internet	NOUN
gs-4060	944	3	]	]	PUNCT
gs-4060	944	4	.	.	PUNCT
gs-4060	945	1	2025	2025	NUM
gs-4060	945	2	may	may	AUX
gs-4060	945	3	30	30	NUM
gs-4060	945	4	[	[	NOUN
gs-4060	945	5	cited	cite	VERB
gs-4060	945	6	2025	2025	NUM
gs-4060	945	7	jul	jul	PROPN
gs-4060	945	8	.	.	PROPN
gs-4060	946	1	12];7(2):381	12];7(2):381	NUM
gs-4060	946	2	-	-	SYM
gs-4060	946	3	419	419	NUM
gs-4060	946	4	.	.	PUNCT
gs-4060	947	1	available	available	ADJ
gs-4060	947	2	from	from	ADP
gs-4060	947	3	:	:	PUNCT
gs-4060	947	4	https://journals.4science.ge/index.php/gs/article/view/3799	https://journals.4science.ge/index.php/gs/article/view/3799	PROPN
gs-4060	947	5	.	.	PUNCT
gs-4060	948	1	58.nodar	58.nodar	PROPN
gs-4060	948	2	sulashvili	sulashvili	NOUN
gs-4060	948	3	,	,	PUNCT
gs-4060	948	4	rupali	rupali	VERB
gs-4060	948	5	digambar	digambar	PROPN
gs-4060	948	6	jadhav	jadhav	PROPN
gs-4060	948	7	,	,	PUNCT
gs-4060	948	8	margarita	margarita	PROPN
gs-4060	948	9	beglaryan	beglaryan	PROPN
gs-4060	948	10	,	,	PUNCT
gs-4060	948	11	nana	nana	PROPN
gs-4060	948	12	gorgaslidze	gorgaslidze	PROPN
gs-4060	948	13	,	,	PUNCT
gs-4060	948	14	luiza	luiza	PROPN
gs-4060	948	15	gabunia	gabunia	PROPN
gs-4060	948	16	,	,	PUNCT
gs-4060	948	17	nato	nato	PROPN
gs-4060	948	18	alavidze	alavidze	PROPN
gs-4060	948	19	,	,	PUNCT
gs-4060	948	20	natia	natia	PROPN
gs-4060	948	21	kvizhinadze	kvizhinadze	PROPN
gs-4060	948	22	,	,	PUNCT
gs-4060	948	23	marika	marika	PROPN
gs-4060	948	24	sulashvili	sulashvili	PROPN
gs-4060	948	25	,	,	PUNCT
gs-4060	948	26	lela	lela	PROPN
gs-4060	948	27	grigolia	grigolia	PROPN
gs-4060	948	28	,	,	PUNCT
gs-4060	948	29	and	and	CCONJ
gs-4060	948	30	kakhaber	kakhaber	PROPN
gs-4060	948	31	robakidze	robakidze	NOUN
gs-4060	948	32	.	.	PUNCT
gs-4060	949	1	2025	2025	NUM
gs-4060	949	2	.	.	PUNCT
gs-4060	950	1	“	"	PUNCT
gs-4060	950	2	the	the	DET
gs-4060	950	3	manifestation	manifestation	NOUN
gs-4060	950	4	of	of	ADP
gs-4060	950	5	pharmacogenetic	pharmacogenetic	ADJ
gs-4060	950	6	and	and	CCONJ
gs-4060	950	7	clinical	clinical	ADJ
gs-4060	950	8	perspectives	perspective	NOUN
gs-4060	950	9	on	on	ADP
gs-4060	950	10	medication	medication	NOUN
gs-4060	950	11	-	-	PUNCT
gs-4060	950	12	associated	associate	VERB
gs-4060	950	13	eosinophilia	eosinophilia	NOUN
gs-4060	950	14	and	and	CCONJ
gs-4060	950	15	systemic	systemic	ADJ
gs-4060	950	16	symptoms	symptom	NOUN
gs-4060	950	17	(	(	PUNCT
gs-4060	950	18	dress	dress	NOUN
gs-4060	950	19	):	):	PUNCT
gs-4060	950	20	a	a	DET
gs-4060	950	21	comprehensive	comprehensive	ADJ
gs-4060	950	22	evaluation	evaluation	NOUN
gs-4060	950	23	of	of	ADP
gs-4060	950	24	implicated	implicated	ADJ
gs-4060	950	25	agents	agent	NOUN
gs-4060	950	26	,	,	PUNCT
gs-4060	950	27	risk	risk	NOUN
gs-4060	950	28	factors	factor	NOUN
gs-4060	950	29	,	,	PUNCT
gs-4060	950	30	and	and	CCONJ
gs-4060	950	31	treatment	treatment	NOUN
gs-4060	950	32	managements	management	NOUN
gs-4060	950	33	strategies	strategy	NOUN
gs-4060	950	34	in	in	ADP
gs-4060	950	35	general	general	ADJ
gs-4060	950	36	”	"	PUNCT
gs-4060	950	37	.	.	PUNCT
gs-4060	951	1	georgian	georgian	PROPN
gs-4060	951	2	scientists	scientist	NOUN
gs-4060	951	3	7	7	NUM
gs-4060	951	4	(	(	PUNCT
gs-4060	951	5	3):180	3):180	NUM
gs-4060	951	6	-	-	SYM
gs-4060	951	7	216	216	NUM
gs-4060	951	8	.	.	PUNCT
gs-4060	952	1	https://doi.org/10.52340/gs.2025.07.03.14	https://doi.org/10.52340/gs.2025.07.03.14	NOUN
gs-4060	952	2	.	.	PUNCT
gs-4060	953	1	59.sulashvili	59.sulashvili	NUM
gs-4060	953	2	,	,	PUNCT
gs-4060	953	3	nodar	nodar	ADV
gs-4060	953	4	,	,	PUNCT
gs-4060	953	5	lali	lali	PROPN
gs-4060	953	6	patsia	patsia	PROPN
gs-4060	953	7	,	,	PUNCT
gs-4060	953	8	awad	awad	PROPN
gs-4060	953	9	el	el	PROPN
gs-4060	953	10	-	-	PUNCT
gs-4060	953	11	hakeem	hakeem	PROPN
gs-4060	953	12	,	,	PUNCT
gs-4060	953	13	sk	sk	PROPN
gs-4060	953	14	ayaan	ayaan	PROPN
gs-4060	953	15	,	,	PUNCT
gs-4060	953	16	arian	arian	ADJ
gs-4060	953	17	hizomi	hizomi	NOUN
gs-4060	953	18	,	,	PUNCT
gs-4060	953	19	sajal	sajal	PROPN
gs-4060	953	20	agarwal	agarwal	PROPN
gs-4060	953	21	,	,	PUNCT
gs-4060	953	22	and	and	CCONJ
gs-4060	953	23	marika	marika	PROPN
gs-4060	953	24	sulashvili	sulashvili	PROPN
gs-4060	953	25	.	.	PUNCT
gs-4060	954	1	2025	2025	NUM
gs-4060	954	2	.	.	PUNCT
gs-4060	955	1	“	"	PUNCT
gs-4060	955	2	exploring	explore	VERB
gs-4060	955	3	the	the	DET
gs-4060	955	4	gut	gut	NOUN
gs-4060	955	5	-	-	PUNCT
gs-4060	955	6	brain	brain	NOUN
gs-4060	955	7	axis	axis	NOUN
gs-4060	955	8	:	:	PUNCT
gs-4060	955	9	the	the	DET
gs-4060	955	10	role	role	NOUN
gs-4060	955	11	of	of	ADP
gs-4060	955	12	the	the	DET
gs-4060	955	13	microbiome	microbiome	NOUN
gs-4060	955	14	in	in	ADP
gs-4060	955	15	modulating	modulate	VERB
gs-4060	955	16	brain	brain	NOUN
gs-4060	955	17	function	function	NOUN
gs-4060	955	18	and	and	CCONJ
gs-4060	955	19	its	its	PRON
gs-4060	955	20	implications	implication	NOUN
gs-4060	955	21	in	in	ADP
gs-4060	955	22	neurodegenerative	neurodegenerative	ADJ
gs-4060	955	23	disorders	disorder	NOUN
gs-4060	955	24	like	like	ADP
gs-4060	955	25	parkinson	parkinson	NOUN
gs-4060	955	26	’s	’s	PART
gs-4060	955	27	and	and	CCONJ
gs-4060	955	28	alzheimer	alzheimer	PROPN
gs-4060	955	29	’s	’s	PART
gs-4060	955	30	and	and	CCONJ
gs-4060	955	31	pharmacotherapy	pharmacotherapy	NOUN
gs-4060	955	32	treatment	treatment	NOUN
gs-4060	955	33	strategies	strategy	NOUN
gs-4060	955	34	”	"	PUNCT
gs-4060	955	35	.	.	PUNCT
gs-4060	956	1	georgian	georgian	PROPN
gs-4060	956	2	scientists	scientist	NOUN
gs-4060	956	3	7	7	NUM
gs-4060	956	4	(	(	PUNCT
gs-4060	956	5	2):329	2):329	NUM
gs-4060	956	6	-	-	SYM
gs-4060	956	7	53	53	NUM
gs-4060	956	8	.	.	PUNCT
gs-4060	957	1	https://doi.org/10.52340/gs.2025.07.02.32	https://doi.org/10.52340/gs.2025.07.02.32	PROPN
gs-4060	957	2	.	.	PROPN
gs-4060	957	3	60.sulashvili	60.sulashvili	PROPN
gs-4060	957	4	,	,	PUNCT
gs-4060	957	5	n.	n.	NOUN
gs-4060	957	6	,	,	PUNCT
gs-4060	957	7	gorgaslidze	gorgaslidze	PROPN
gs-4060	957	8	,	,	PUNCT
gs-4060	957	9	n.	n.	NOUN
gs-4060	957	10	,	,	PUNCT
gs-4060	957	11	gabunia	gabunia	NOUN
gs-4060	957	12	,	,	PUNCT
gs-4060	957	13	l.	l.	PROPN
gs-4060	957	14	,	,	PUNCT
gs-4060	957	15	giorgobiani	giorgobiani	PROPN
gs-4060	957	16	,	,	PUNCT
gs-4060	957	17	m.	m.	NOUN
gs-4060	957	18	,	,	PUNCT
gs-4060	957	19	&	&	CCONJ
gs-4060	957	20	ratiani	ratiani	PROPN
gs-4060	957	21	,	,	PUNCT
gs-4060	957	22	l.	l.	PROPN
gs-4060	957	23	(	(	PUNCT
gs-4060	957	24	2023	2023	NUM
gs-4060	957	25	)	)	PUNCT
gs-4060	957	26	.	.	PUNCT
gs-4060	958	1	manifestation	manifestation	NOUN
gs-4060	958	2	of	of	ADP
gs-4060	958	3	the	the	DET
gs-4060	958	4	particularities	particularity	NOUN
gs-4060	958	5	of	of	ADP
gs-4060	958	6	the	the	DET
gs-4060	958	7	usage	usage	NOUN
gs-4060	958	8	features	feature	NOUN
gs-4060	958	9	of	of	ADP
gs-4060	958	10	monoclonal	monoclonal	NOUN
gs-4060	958	11	antibodies	antibody	NOUN
gs-4060	958	12	in	in	ADP
gs-4060	958	13	various	various	ADJ
gs-4060	958	14	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-4060	958	15	applications	application	NOUN
gs-4060	958	16	.	.	PUNCT
gs-4060	959	1	experimental	experimental	ADJ
gs-4060	959	2	and	and	CCONJ
gs-4060	959	3	clinical	clinical	ADJ
gs-4060	959	4	medicine	medicine	NOUN
gs-4060	959	5	georgia	georgia	PROPN
gs-4060	959	6	,	,	PUNCT
gs-4060	959	7	(	(	PUNCT
gs-4060	959	8	4	4	NUM
gs-4060	959	9	)	)	PUNCT
gs-4060	959	10	,	,	PUNCT
gs-4060	959	11	52–57	52–57	NUM
gs-4060	959	12	.	.	PUNCT
gs-4060	960	1	61.sulashvili	61.sulashvili	NUM
gs-4060	960	2	,	,	PUNCT
gs-4060	960	3	n.	n.	NOUN
gs-4060	960	4	,	,	PUNCT
gs-4060	960	5	davitashvili	davitashvili	ADJ
gs-4060	960	6	,	,	PUNCT
gs-4060	960	7	m.	m.	NOUN
gs-4060	960	8	,	,	PUNCT
gs-4060	960	9	gorgaslidze	gorgaslidze	PROPN
gs-4060	960	10	,	,	PUNCT
gs-4060	960	11	n.	n.	NOUN
gs-4060	960	12	,	,	PUNCT
gs-4060	960	13	gabunia	gabunia	NOUN
gs-4060	960	14	,	,	PUNCT
gs-4060	960	15	l.	l.	PROPN
gs-4060	960	16	,	,	PUNCT
gs-4060	960	17	beglaryan	beglaryan	ADJ
gs-4060	960	18	,	,	PUNCT
gs-4060	960	19	m.	m.	NOUN
gs-4060	960	20	,	,	PUNCT
gs-4060	960	21	alavidze	alavidze	NOUN
gs-4060	960	22	,	,	PUNCT
gs-4060	960	23	n.	n.	NOUN
gs-4060	960	24	,	,	PUNCT
gs-4060	960	25	…	…	PUNCT
gs-4060	960	26	sulashvili	sulashvili	NOUN
gs-4060	960	27	,	,	PUNCT
gs-4060	960	28	m.	m.	NOUN
gs-4060	960	29	(	(	PUNCT
gs-4060	960	30	2024	2024	NUM
gs-4060	960	31	)	)	PUNCT
gs-4060	960	32	.	.	PUNCT
gs-4060	961	1	the	the	DET
gs-4060	961	2	scientific	scientific	ADJ
gs-4060	961	3	discussion	discussion	NOUN
gs-4060	961	4	of	of	ADP
gs-4060	961	5	some	some	DET
gs-4060	961	6	issues	issue	NOUN
gs-4060	961	7	of	of	ADP
gs-4060	961	8	features	feature	NOUN
gs-4060	961	9	and	and	CCONJ
gs-4060	961	10	challenges	challenge	NOUN
gs-4060	961	11	of	of	ADP
gs-4060	961	12	using	use	VERB
gs-4060	961	13	of	of	ADP
gs-4060	961	14	car	car	NOUN
gs-4060	961	15	-	-	PUNCT
gs-4060	961	16	t	t	NOUN
gs-4060	961	17	cells	cell	NOUN
gs-4060	961	18	in	in	ADP
gs-4060	961	19	immunotherapy	immunotherapy	NOUN
gs-4060	961	20	.	.	PUNCT
gs-4060	962	1	georgian	georgian	ADJ
gs-4060	962	2	scientists	scientist	NOUN
gs-4060	962	3	,	,	PUNCT
gs-4060	962	4	6(4	6(4	NOUN
gs-4060	962	5	)	)	PUNCT
gs-4060	962	6	,	,	PUNCT
gs-4060	962	7	263–290	263–290	NUM
gs-4060	962	8	.	.	PUNCT
gs-4060	963	1	https://doi.org/10.52340/gs.2024.06.04.24	https://doi.org/10.52340/gs.2024.06.04.24	PROPN
gs-4060	963	2	62.sulashvili	62.sulashvili	NUM
gs-4060	963	3	,	,	PUNCT
gs-4060	963	4	n.	n.	NOUN
gs-4060	963	5	,	,	PUNCT
gs-4060	963	6	gorgaslidze	gorgaslidze	PROPN
gs-4060	963	7	,	,	PUNCT
gs-4060	963	8	n.	n.	NOUN
gs-4060	963	9	,	,	PUNCT
gs-4060	963	10	gabunia	gabunia	NOUN
gs-4060	963	11	,	,	PUNCT
gs-4060	963	12	l.	l.	PROPN
gs-4060	963	13	,	,	PUNCT
gs-4060	963	14	giorgobiani	giorgobiani	PROPN
gs-4060	963	15	,	,	PUNCT
gs-4060	963	16	m.	m.	NOUN
gs-4060	963	17	,	,	PUNCT
gs-4060	963	18	&	&	CCONJ
gs-4060	963	19	ratiani	ratiani	PROPN
gs-4060	963	20	,	,	PUNCT
gs-4060	963	21	l.	l.	PROPN
gs-4060	963	22	(	(	PUNCT
gs-4060	963	23	2023	2023	NUM
gs-4060	963	24	)	)	PUNCT
gs-4060	963	25	.	.	PUNCT
gs-4060	964	1	manifestation	manifestation	NOUN
gs-4060	964	2	of	of	ADP
gs-4060	964	3	the	the	DET
gs-4060	964	4	particularities	particularity	NOUN
gs-4060	964	5	of	of	ADP
gs-4060	964	6	the	the	DET
gs-4060	964	7	usage	usage	NOUN
gs-4060	964	8	features	feature	NOUN
gs-4060	964	9	of	of	ADP
gs-4060	964	10	monoclonal	monoclonal	NOUN
gs-4060	964	11	antibodies	antibody	NOUN
gs-4060	964	12	in	in	ADP
gs-4060	964	13	various	various	ADJ
gs-4060	964	14	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-4060	964	15	applications	application	NOUN
gs-4060	964	16	.	.	PUNCT
gs-4060	965	1	experimental	experimental	ADJ
gs-4060	965	2	and	and	CCONJ
gs-4060	965	3	clinical	clinical	ADJ
gs-4060	965	4	medicine	medicine	NOUN
gs-4060	965	5	georgia	georgia	PROPN
gs-4060	965	6	,	,	PUNCT
gs-4060	965	7	(	(	PUNCT
gs-4060	965	8	4	4	NUM
gs-4060	965	9	)	)	PUNCT
gs-4060	965	10	,	,	PUNCT
gs-4060	965	11	52–57	52–57	NUM
gs-4060	965	12	.	.	PUNCT
gs-4060	965	13	https://doi.org/10.52340/jecm.2023.04.14	https://doi.org/10.52340/jecm.2023.04.14	X
gs-4060	966	1	georgian	georgian	NOUN
gs-4060	966	2	scientists/	scientists/	NUM
gs-4060	966	3	.	.	PUNCT
gs-4060	967	1	7	7	NUM
gs-4060	967	2	n	n	PRON
gs-4060	967	3	3	3	NUM
gs-4060	967	4	,	,	PUNCT
gs-4060	967	5	2025	2025	NUM
gs-4060	967	6	608	608	NUM
gs-4060	967	7	63.sulashvili	63.sulashvili	NUM
gs-4060	967	8	,	,	PUNCT
gs-4060	967	9	n.	n.	NOUN
gs-4060	967	10	,	,	PUNCT
gs-4060	967	11	gorgaslidze	gorgaslidze	PROPN
gs-4060	967	12	,	,	PUNCT
gs-4060	967	13	n.	n.	NOUN
gs-4060	967	14	,	,	PUNCT
gs-4060	967	15	gabunia	gabunia	NOUN
gs-4060	967	16	,	,	PUNCT
gs-4060	967	17	l.	l.	PROPN
gs-4060	967	18	,	,	PUNCT
gs-4060	967	19	ratiani	ratiani	PROPN
gs-4060	967	20	,	,	PUNCT
gs-4060	967	21	l.	l.	PROPN
gs-4060	967	22	,	,	PUNCT
gs-4060	967	23	khetsuriani	khetsuriani	PROPN
gs-4060	967	24	,	,	PUNCT
gs-4060	967	25	s.	s.	PROPN
gs-4060	967	26	,	,	PUNCT
gs-4060	967	27	kravchenko	kravchenko	PROPN
gs-4060	967	28	,	,	PUNCT
gs-4060	967	29	v.	v.	NOUN
gs-4060	967	30	,	,	PUNCT
gs-4060	967	31	sulashvili	sulashvili	NOUN
gs-4060	967	32	,	,	PUNCT
gs-4060	967	33	m.	m.	NOUN
gs-4060	967	34	(	(	PUNCT
gs-4060	967	35	2024	2024	NUM
gs-4060	967	36	)	)	PUNCT
gs-4060	967	37	.	.	PUNCT
gs-4060	968	1	manifestation	manifestation	NOUN
gs-4060	968	2	of	of	ADP
gs-4060	968	3	the	the	DET
gs-4060	968	4	particularities	particularity	NOUN
gs-4060	968	5	of	of	ADP
gs-4060	968	6	some	some	DET
gs-4060	968	7	key	key	ADJ
gs-4060	968	8	issue	issue	NOUN
gs-4060	968	9	aspects	aspect	NOUN
gs-4060	968	10	of	of	ADP
gs-4060	968	11	new	new	ADJ
gs-4060	968	12	immunotherapy	immunotherapy	NOUN
gs-4060	968	13	challenges	challenge	NOUN
gs-4060	968	14	and	and	CCONJ
gs-4060	968	15	perspectives	perspective	NOUN
gs-4060	968	16	by	by	ADP
gs-4060	968	17	car	car	NOUN
gs-4060	968	18	-	-	PUNCT
gs-4060	968	19	t	t	NOUN
gs-4060	968	20	cell	cell	NOUN
gs-4060	968	21	therapy	therapy	NOUN
gs-4060	968	22	.	.	PUNCT
gs-4060	969	1	experimental	experimental	ADJ
gs-4060	969	2	and	and	CCONJ
gs-4060	969	3	clinical	clinical	ADJ
gs-4060	969	4	medicine	medicine	NOUN
gs-4060	969	5	georgia	georgia	PROPN
gs-4060	969	6	,	,	PUNCT
gs-4060	969	7	(	(	PUNCT
gs-4060	969	8	4	4	NUM
gs-4060	969	9	)	)	PUNCT
gs-4060	969	10	,	,	PUNCT
gs-4060	969	11	119–121	119–121	NUM
gs-4060	969	12	.	.	PUNCT
gs-4060	969	13	https://doi.org/10.52340/jecm.2024.04.32	https://doi.org/10.52340/jecm.2024.04.32	NUM
gs-4060	969	14	.	.	PUNCT
gs-4060	970	1	64.sulashvili	64.sulashvili	NUM
gs-4060	970	2	,	,	PUNCT
gs-4060	970	3	n.	n.	NOUN
gs-4060	970	4	.	.	PUNCT
gs-4060	971	1	.	.	PUNCT
gs-4060	971	2	,	,	PUNCT
gs-4060	972	1	gorgaslidze	gorgaslidze	INTJ
gs-4060	972	2	,	,	PUNCT
gs-4060	972	3	n.	n.	PROPN
gs-4060	972	4	.	.	PUNCT
gs-4060	973	1	,	,	PUNCT
gs-4060	973	2	beglaryan	beglaryan	ADJ
gs-4060	973	3	,	,	PUNCT
gs-4060	973	4	m.	m.	NOUN
gs-4060	973	5	.	.	PUNCT
gs-4060	973	6	,	,	PUNCT
gs-4060	973	7	gabunia	gabunia	NOUN
gs-4060	973	8	,	,	PUNCT
gs-4060	973	9	l.	l.	PROPN
gs-4060	973	10	.	.	PROPN
gs-4060	973	11	,	,	PUNCT
gs-4060	973	12	chichoyan	chichoyan	PROPN
gs-4060	973	13	,	,	PUNCT
gs-4060	973	14	n.	n.	PROPN
gs-4060	973	15	.	.	PUNCT
gs-4060	973	16	,	,	PUNCT
gs-4060	973	17	giorgobiani	giorgobiani	PROPN
gs-4060	973	18	,	,	PUNCT
gs-4060	973	19	m.	m.	NOUN
gs-4060	973	20	.	.	PUNCT
gs-4060	974	1	,	,	PUNCT
gs-4060	974	2	…	…	PUNCT
gs-4060	974	3	zarnadze	zarnadze	INTJ
gs-4060	974	4	,	,	PUNCT
gs-4060	974	5	s.	s.	PROPN
gs-4060	974	6	(	(	PUNCT
gs-4060	974	7	davit	davit	PROPN
gs-4060	974	8	)	)	PUNCT
gs-4060	974	9	.	.	PUNCT
gs-4060	975	1	(	(	PUNCT
gs-4060	975	2	2022	2022	NUM
gs-4060	975	3	)	)	PUNCT
gs-4060	975	4	.	.	PUNCT
gs-4060	976	1	the	the	DET
gs-4060	976	2	scientific	scientific	ADJ
gs-4060	976	3	talks	talk	NOUN
gs-4060	976	4	of	of	ADP
gs-4060	976	5	essential	essential	ADJ
gs-4060	976	6	issue	issue	NOUN
gs-4060	976	7	,	,	PUNCT
gs-4060	976	8	invocation	invocation	NOUN
gs-4060	976	9	,	,	PUNCT
gs-4060	976	10	perspectives	perspective	NOUN
gs-4060	976	11	,	,	PUNCT
gs-4060	976	12	inclinations	inclination	NOUN
gs-4060	976	13	and	and	CCONJ
gs-4060	976	14	features	feature	NOUN
gs-4060	976	15	of	of	ADP
gs-4060	976	16	the	the	DET
gs-4060	976	17	clinical	clinical	ADJ
gs-4060	976	18	pharmacists	pharmacist	NOUN
gs-4060	976	19	globally	globally	ADV
gs-4060	976	20	.	.	PUNCT
gs-4060	977	1	experimental	experimental	ADJ
gs-4060	977	2	and	and	CCONJ
gs-4060	977	3	clinical	clinical	ADJ
gs-4060	977	4	medicine	medicine	NOUN
gs-4060	977	5	georgia	georgia	PROPN
gs-4060	977	6	,	,	PUNCT
gs-4060	977	7	(	(	PUNCT
gs-4060	977	8	7	7	NUM
gs-4060	977	9	)	)	PUNCT
gs-4060	977	10	.	.	PUNCT
gs-4060	978	1	65.sulashvili	65.sulashvili	NUM
gs-4060	978	2	n	n	CCONJ
gs-4060	978	3	,	,	PUNCT
gs-4060	978	4	nimangre	nimangre	PROPN
gs-4060	978	5	rr	rr	PROPN
gs-4060	978	6	.	.	PUNCT
gs-4060	979	1	manifestation	manifestation	NOUN
gs-4060	979	2	of	of	ADP
gs-4060	979	3	some	some	DET
gs-4060	979	4	aspects	aspect	NOUN
gs-4060	979	5	of	of	ADP
gs-4060	979	6	cardiovascular	cardiovascular	ADJ
gs-4060	979	7	diseases	disease	NOUN
gs-4060	979	8	,	,	PUNCT
gs-4060	979	9	implications	implication	NOUN
gs-4060	979	10	,	,	PUNCT
gs-4060	979	11	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-4060	979	12	strategies	strategy	NOUN
gs-4060	979	13	,	,	PUNCT
gs-4060	979	14	effects	effect	NOUN
gs-4060	979	15	,	,	PUNCT
gs-4060	979	16	impacts	impact	NOUN
gs-4060	979	17	and	and	CCONJ
gs-4060	979	18	potential	potential	ADJ
gs-4060	979	19	hazards	hazard	NOUN
gs-4060	979	20	in	in	ADP
gs-4060	979	21	general	general	ADJ
gs-4060	979	22	.	.	PUNCT
gs-4060	980	1	jr	jr	PROPN
gs-4060	981	1	[	[	X
gs-4060	981	2	internet	internet	NOUN
gs-4060	981	3	]	]	PUNCT
gs-4060	981	4	.	.	PUNCT
gs-4060	982	1	2025	2025	NUM
gs-4060	982	2	feb	feb	X
gs-4060	982	3	.	.	PROPN
gs-4060	982	4	7	7	NUM
gs-4060	982	5	[	[	X
gs-4060	982	6	cited	cite	VERB
gs-4060	982	7	2025	2025	NUM
gs-4060	982	8	may	may	PROPN
gs-4060	982	9	22];3(1):1	22];3(1):1	NUM
gs-4060	982	10	-	-	SYM
gs-4060	982	11	27	27	NUM
gs-4060	982	12	.	.	PUNCT
gs-4060	983	1	available	available	ADJ
gs-4060	983	2	from	from	ADP
gs-4060	983	3	:	:	PUNCT
gs-4060	983	4	https://journals.4science.ge/index.php/jr/article/view/3393	https://journals.4science.ge/index.php/jr/article/view/3393	PROPN
gs-4060	983	5	.	.	PUNCT
gs-4060	984	1	66.sulashvili	66.sulashvili	NUM
gs-4060	984	2	n	n	CCONJ
gs-4060	984	3	,	,	PUNCT
gs-4060	984	4	yaduvanshi	yaduvanshi	NOUN
gs-4060	984	5	u	u	NOUN
gs-4060	984	6	,	,	PUNCT
gs-4060	984	7	yadav	yadav	PROPN
gs-4060	984	8	m	m	PROPN
gs-4060	984	9	,	,	PUNCT
gs-4060	984	10	gabunia	gabunia	NOUN
gs-4060	984	11	l	l	NOUN
gs-4060	984	12	,	,	PUNCT
gs-4060	984	13	ghambashidze	ghambashidze	PROPN
gs-4060	984	14	k	k	PROPN
gs-4060	984	15	,	,	PUNCT
gs-4060	984	16	gorgaslidze	gorgaslidze	ADJ
gs-4060	984	17	n	n	CCONJ
gs-4060	984	18	,	,	PUNCT
gs-4060	984	19	et	et	PROPN
gs-4060	984	20	al	al	PROPN
gs-4060	984	21	.	.	PUNCT
gs-4060	985	1	the	the	DET
gs-4060	985	2	scientific	scientific	ADJ
gs-4060	985	3	discourse	discourse	NOUN
gs-4060	985	4	of	of	ADP
gs-4060	985	5	features	feature	NOUN
gs-4060	985	6	of	of	ADP
gs-4060	985	7	clinical	clinical	ADJ
gs-4060	985	8	use	use	NOUN
gs-4060	985	9	and	and	CCONJ
gs-4060	985	10	pharmacology	pharmacology	NOUN
gs-4060	985	11	of	of	ADP
gs-4060	985	12	vasoconstrictors	vasoconstrictor	NOUN
gs-4060	985	13	and	and	CCONJ
gs-4060	985	14	their	their	PRON
gs-4060	985	15	impact	impact	NOUN
gs-4060	985	16	on	on	ADP
gs-4060	985	17	cardiac	cardiac	ADJ
gs-4060	985	18	function	function	NOUN
gs-4060	985	19	.	.	PUNCT
gs-4060	986	1	jr	jr	PROPN
gs-4060	987	1	[	[	X
gs-4060	987	2	internet	internet	NOUN
gs-4060	987	3	]	]	PUNCT
gs-4060	987	4	.	.	PUNCT
gs-4060	988	1	2025	2025	NUM
gs-4060	988	2	feb	feb	X
gs-4060	988	3	.	.	PROPN
gs-4060	988	4	21	21	NUM
gs-4060	988	5	[	[	X
gs-4060	988	6	cited	cite	VERB
gs-4060	988	7	2025	2025	NUM
gs-4060	988	8	may	may	PROPN
gs-4060	988	9	22];3(1):28	22];3(1):28	NUM
gs-4060	988	10	-	-	SYM
gs-4060	988	11	6	6	NUM
gs-4060	988	12	.	.	PUNCT
gs-4060	989	1	available	available	ADJ
gs-4060	989	2	from	from	ADP
gs-4060	989	3	:	:	PUNCT
gs-4060	989	4	https://journals.4science.ge/index.php/jr/article/view/3414	https://journals.4science.ge/index.php/jr/article/view/3414	PROPN
gs-4060	989	5	.	.	PUNCT
gs-4060	990	1	67.nodar	67.nodar	NUM
gs-4060	990	2	sulashvili	sulashvili	NOUN
gs-4060	990	3	,	,	PUNCT
gs-4060	990	4	nana	nana	PROPN
gs-4060	990	5	gorgaslidze	gorgaslidze	PROPN
gs-4060	990	6	,	,	PUNCT
gs-4060	990	7	margarita	margarita	PROPN
gs-4060	990	8	beglaryan	beglaryan	PROPN
gs-4060	990	9	,	,	PUNCT
gs-4060	990	10	luiza	luiza	PROPN
gs-4060	990	11	gabunia	gabunia	PROPN
gs-4060	990	12	,	,	PUNCT
gs-4060	990	13	nato	nato	PROPN
gs-4060	990	14	alavidze	alavidze	PROPN
gs-4060	990	15	,	,	PUNCT
gs-4060	990	16	nino	nino	PROPN
gs-4060	990	17	abuladze	abuladze	PROPN
gs-4060	990	18	,	,	PUNCT
gs-4060	990	19	marina	marina	PROPN
gs-4060	990	20	giorgobiani	giorgobiani	PROPN
gs-4060	990	21	,	,	PUNCT
gs-4060	990	22	marika	marika	PROPN
gs-4060	990	23	sulashvili	sulashvili	PROPN
gs-4060	990	24	,	,	PUNCT
gs-4060	990	25	tamar	tamar	PROPN
gs-4060	990	26	okropiridze	okropiridze	PROPN
gs-4060	990	27	,	,	PUNCT
gs-4060	990	28	and	and	CCONJ
gs-4060	990	29	lali	lali	PROPN
gs-4060	990	30	patsia	patsia	PROPN
gs-4060	990	31	.	.	PUNCT
gs-4060	991	1	2025	2025	NUM
gs-4060	991	2	.	.	PUNCT
gs-4060	992	1	“	"	PUNCT
gs-4060	992	2	the	the	DET
gs-4060	992	3	scientific	scientific	ADJ
gs-4060	992	4	discourse	discourse	NOUN
gs-4060	992	5	of	of	ADP
gs-4060	992	6	key	key	ADJ
gs-4060	992	7	issue	issue	NOUN
gs-4060	992	8	aspects	aspect	NOUN
gs-4060	992	9	of	of	ADP
gs-4060	992	10	features	feature	NOUN
gs-4060	992	11	of	of	ADP
gs-4060	992	12	candida	candida	PROPN
gs-4060	992	13	problems	problem	NOUN
gs-4060	992	14	,	,	PUNCT
gs-4060	992	15	antifungal	antifungal	ADJ
gs-4060	992	16	drugs	drug	NOUN
gs-4060	992	17	resistance	resistance	NOUN
gs-4060	992	18	concerns	concern	NOUN
gs-4060	992	19	,	,	PUNCT
gs-4060	992	20	mycotoxicology	mycotoxicology	NOUN
gs-4060	992	21	issues	issue	NOUN
gs-4060	992	22	,	,	PUNCT
gs-4060	992	23	mycoecology	mycoecology	NOUN
gs-4060	992	24	,	,	PUNCT
gs-4060	992	25	biosafety	biosafety	NOUN
gs-4060	992	26	risks	risk	NOUN
gs-4060	992	27	and	and	CCONJ
gs-4060	992	28	emerging	emerge	VERB
gs-4060	992	29	solutions	solution	NOUN
gs-4060	992	30	”	"	PUNCT
gs-4060	992	31	.	.	PUNCT
gs-4060	993	1	modern	modern	ADJ
gs-4060	993	2	scientific	scientific	ADJ
gs-4060	993	3	method	method	NOUN
gs-4060	993	4	,	,	PUNCT
gs-4060	993	5	no	no	INTJ
gs-4060	993	6	.	.	NOUN
gs-4060	993	7	9	9	NUM
gs-4060	993	8	(	(	PUNCT
gs-4060	993	9	march	march	PROPN
gs-4060	993	10	)	)	PUNCT
gs-4060	993	11	.	.	PUNCT
gs-4060	994	1	https://ojs.scipub.de/index.php/msm/article/view/5423	https://ojs.scipub.de/index.php/msm/article/view/5423	NOUN
gs-4060	994	2	.	.	PUNCT
gs-4060	995	1	68.aphkhazava	68.aphkhazava	NUM
gs-4060	995	2	,	,	PUNCT
gs-4060	995	3	d.	d.	PROPN
gs-4060	995	4	,	,	PUNCT
gs-4060	995	5	tuphinashvili	tuphinashvili	NOUN
gs-4060	995	6	,	,	PUNCT
gs-4060	995	7	t.	t.	NOUN
gs-4060	995	8	,	,	PUNCT
gs-4060	995	9	sulashvili	sulashvili	NOUN
gs-4060	995	10	,	,	PUNCT
gs-4060	995	11	n.	n.	NOUN
gs-4060	995	12	,	,	PUNCT
gs-4060	995	13	&	&	CCONJ
gs-4060	995	14	nozadze	nozadze	NOUN
gs-4060	995	15	,	,	PUNCT
gs-4060	995	16	m.	m.	NOUN
gs-4060	995	17	(	(	PUNCT
gs-4060	995	18	2023	2023	NUM
gs-4060	995	19	)	)	PUNCT
gs-4060	995	20	.	.	PUNCT
gs-4060	996	1	the	the	DET
gs-4060	996	2	features	feature	NOUN
gs-4060	996	3	and	and	CCONJ
gs-4060	996	4	role	role	NOUN
gs-4060	996	5	of	of	ADP
gs-4060	996	6	shp2	shp2	ADJ
gs-4060	996	7	protein	protein	NOUN
gs-4060	996	8	in	in	ADP
gs-4060	996	9	postnatal	postnatal	ADJ
gs-4060	996	10	muscle	muscle	NOUN
gs-4060	996	11	development	development	NOUN
gs-4060	996	12	.	.	PUNCT
gs-4060	997	1	scientific	scientific	ADJ
gs-4060	997	2	journal	journal	NOUN
gs-4060	997	3	„	„	PUNCT
gs-4060	997	4	spectri	spectri	NOUN
gs-4060	997	5	“	"	PUNCT
gs-4060	997	6	,	,	PUNCT
gs-4060	997	7	1	1	X
gs-4060	997	8	.	.	PUNCT
gs-4060	998	1	https://doi.org/10.52340/spectri.2023.01	https://doi.org/10.52340/spectri.2023.01	DET
gs-4060	998	2	69.sulashvili	69.sulashvili	NUM
gs-4060	998	3	,	,	PUNCT
gs-4060	998	4	n.	n.	NOUN
gs-4060	998	5	,	,	PUNCT
gs-4060	998	6	beglaryan	beglaryan	ADJ
gs-4060	998	7	,	,	PUNCT
gs-4060	998	8	m.	m.	NOUN
gs-4060	998	9	,	,	PUNCT
gs-4060	998	10	gorgaslidze	gorgaslidze	PROPN
gs-4060	998	11	,	,	PUNCT
gs-4060	998	12	n.	n.	PROPN
gs-4060	998	13	,	,	PUNCT
gs-4060	998	14	kocharyan	kocharyan	PROPN
gs-4060	998	15	,	,	PUNCT
gs-4060	998	16	s.	s.	PROPN
gs-4060	998	17	,	,	PUNCT
gs-4060	998	18	chichoyan	chichoyan	PROPN
gs-4060	998	19	,	,	PUNCT
gs-4060	998	20	n.	n.	NOUN
gs-4060	998	21	,	,	PUNCT
gs-4060	998	22	gabunia	gabunia	NOUN
gs-4060	998	23	,	,	PUNCT
gs-4060	998	24	l.	l.	PROPN
gs-4060	998	25	,	,	PUNCT
gs-4060	998	26	zarnadze	zarnadze	PROPN
gs-4060	998	27	,	,	PUNCT
gs-4060	998	28	s.	s.	PROPN
gs-4060	998	29	(	(	PUNCT
gs-4060	998	30	davit	davit	PROPN
gs-4060	998	31	)	)	PUNCT
gs-4060	998	32	.	.	PUNCT
gs-4060	999	1	(	(	PUNCT
gs-4060	999	2	2023	2023	NUM
gs-4060	999	3	)	)	PUNCT
gs-4060	999	4	.	.	PUNCT
gs-4060	1000	1	the	the	DET
gs-4060	1000	2	disclosure	disclosure	NOUN
gs-4060	1000	3	of	of	ADP
gs-4060	1000	4	features	feature	NOUN
gs-4060	1000	5	,	,	PUNCT
gs-4060	1000	6	characteristics	characteristic	NOUN
gs-4060	1000	7	,	,	PUNCT
gs-4060	1000	8	possibilities	possibility	NOUN
gs-4060	1000	9	and	and	CCONJ
gs-4060	1000	10	specialties	specialty	NOUN
gs-4060	1000	11	of	of	ADP
gs-4060	1000	12	clinical	clinical	ADJ
gs-4060	1000	13	pharmacists	pharmacist	NOUN
gs-4060	1000	14	as	as	ADP
gs-4060	1000	15	mediator	mediator	NOUN
gs-4060	1000	16	among	among	ADP
gs-4060	1000	17	doctors	doctor	NOUN
gs-4060	1000	18	and	and	CCONJ
gs-4060	1000	19	patients	patient	NOUN
gs-4060	1000	20	for	for	ADP
gs-4060	1000	21	enhancement	enhancement	NOUN
gs-4060	1000	22	public	public	ADJ
gs-4060	1000	23	health	health	NOUN
gs-4060	1000	24	sector	sector	NOUN
gs-4060	1000	25	in	in	ADP
gs-4060	1000	26	a	a	DET
gs-4060	1000	27	global	global	ADJ
gs-4060	1000	28	world	world	NOUN
gs-4060	1000	29	.	.	PUNCT
gs-4060	1001	1	experimental	experimental	ADJ
gs-4060	1001	2	and	and	CCONJ
gs-4060	1001	3	clinical	clinical	ADJ
gs-4060	1001	4	medicine	medicine	NOUN
gs-4060	1001	5	georgia	georgia	PROPN
gs-4060	1001	6	,	,	PUNCT
gs-4060	1001	7	(	(	PUNCT
gs-4060	1001	8	4	4	NUM
gs-4060	1001	9	)	)	PUNCT
gs-4060	1001	10	,	,	PUNCT
gs-4060	1001	11	57–62	57–62	NUM
gs-4060	1001	12	.	.	PUNCT
gs-4060	1002	1	https://doi.org/10.52340/jecm.2023.04.15	https://doi.org/10.52340/jecm.2023.04.15	PROPN
gs-4060	1002	2	70.sulashvili	70.sulashvili	NUM
gs-4060	1002	3	n	n	CCONJ
gs-4060	1002	4	,	,	PUNCT
gs-4060	1002	5	davitashvili	davitashvili	NOUN
gs-4060	1002	6	m	m	PROPN
gs-4060	1002	7	,	,	PUNCT
gs-4060	1002	8	gorgaslidze	gorgaslidze	ADJ
gs-4060	1002	9	n	n	CCONJ
gs-4060	1002	10	,	,	PUNCT
gs-4060	1002	11	gabunia	gabunia	NOUN
gs-4060	1002	12	l	l	NOUN
gs-4060	1002	13	,	,	PUNCT
gs-4060	1002	14	beglaryan	beglaryan	PROPN
gs-4060	1002	15	m	m	PROPN
gs-4060	1002	16	,	,	PUNCT
gs-4060	1002	17	alavidze	alavidze	PROPN
gs-4060	1002	18	n	n	CCONJ
gs-4060	1002	19	,	,	PUNCT
gs-4060	1002	20	et	et	PROPN
gs-4060	1002	21	al	al	PROPN
gs-4060	1002	22	.	.	PUNCT
gs-4060	1003	1	the	the	DET
gs-4060	1003	2	scientific	scientific	ADJ
gs-4060	1003	3	discussion	discussion	NOUN
gs-4060	1003	4	of	of	ADP
gs-4060	1003	5	some	some	DET
gs-4060	1003	6	issues	issue	NOUN
gs-4060	1003	7	of	of	ADP
gs-4060	1003	8	features	feature	NOUN
gs-4060	1003	9	and	and	CCONJ
gs-4060	1003	10	challenges	challenge	NOUN
gs-4060	1003	11	of	of	ADP
gs-4060	1003	12	using	use	VERB
gs-4060	1003	13	of	of	ADP
gs-4060	1003	14	car	car	NOUN
gs-4060	1003	15	-	-	PUNCT
gs-4060	1003	16	t	t	NOUN
gs-4060	1003	17	cells	cell	NOUN
gs-4060	1003	18	in	in	ADP
gs-4060	1003	19	immunotherapy	immunotherapy	NOUN
gs-4060	1003	20	.	.	PUNCT
gs-4060	1004	1	gs	gs	PROPN
gs-4060	1004	2	2024	2024	NUM
gs-4060	1004	3	;	;	PUNCT
gs-4060	1004	4	6(4):263	6(4):263	NUM
gs-4060	1004	5	-	-	SYM
gs-4060	1004	6	90	90	NUM
gs-4060	1004	7	.	.	PUNCT
gs-4060	1005	1	https://journals.4science.ge/index.php/gs/article/view/3214	https://journals.4science.ge/index.php/gs/article/view/3214	PROPN
gs-4060	1006	1	71.aphkhazava	71.aphkhazava	NUM
gs-4060	1006	2	,	,	PUNCT
gs-4060	1006	3	david	david	PROPN
gs-4060	1006	4	,	,	PUNCT
gs-4060	1006	5	nodar	nodar	NOUN
gs-4060	1006	6	sulashvili	sulashvili	NOUN
gs-4060	1006	7	,	,	PUNCT
gs-4060	1006	8	and	and	CCONJ
gs-4060	1006	9	jaba	jaba	PROPN
gs-4060	1006	10	tkemaladze	tkemaladze	PROPN
gs-4060	1006	11	.	.	PUNCT
gs-4060	1007	1	2025	2025	NUM
gs-4060	1007	2	.	.	PUNCT
gs-4060	1008	1	“	"	PUNCT
gs-4060	1008	2	stem	stem	NOUN
gs-4060	1008	3	cell	cell	NOUN
gs-4060	1008	4	systems	system	NOUN
gs-4060	1008	5	and	and	CCONJ
gs-4060	1008	6	regeneration	regeneration	NOUN
gs-4060	1008	7	”	"	PUNCT
gs-4060	1008	8	.	.	PUNCT
gs-4060	1009	1	georgian	georgian	PROPN
gs-4060	1009	2	scientists	scientist	NOUN
gs-4060	1009	3	7	7	NUM
gs-4060	1009	4	(	(	PUNCT
gs-4060	1009	5	1):271	1):271	NUM
gs-4060	1009	6	-	-	SYM
gs-4060	1009	7	319	319	NUM
gs-4060	1009	8	.	.	PUNCT
gs-4060	1010	1	https://doi.org/10.52340/gs.2025.07.01.26	https://doi.org/10.52340/gs.2025.07.01.26	X
gs-4060	1010	2	.	.	PUNCT
gs-4060	1011	1	72.relling	72.relling	NUM
gs-4060	1011	2	,	,	PUNCT
gs-4060	1011	3	mary	mary	PROPN
gs-4060	1011	4	v.	v.	PROPN
gs-4060	1011	5	,	,	PUNCT
gs-4060	1011	6	and	and	CCONJ
gs-4060	1011	7	william	william	PROPN
gs-4060	1011	8	e.	e.	PROPN
gs-4060	1011	9	evans	evans	PROPN
gs-4060	1011	10	.	.	PROPN
gs-4060	1012	1	2015	2015	NUM
gs-4060	1012	2	.	.	PUNCT
gs-4060	1013	1	“	"	PUNCT
gs-4060	1013	2	pharmacogenomics	pharmacogenomic	NOUN
gs-4060	1013	3	in	in	ADP
gs-4060	1013	4	the	the	DET
gs-4060	1013	5	clinic	clinic	NOUN
gs-4060	1013	6	.	.	PUNCT
gs-4060	1013	7	”	"	PUNCT
gs-4060	1014	1	nature	nature	NOUN
gs-4060	1014	2	526	526	NUM
gs-4060	1014	3	(	(	PUNCT
gs-4060	1014	4	7573	7573	NUM
gs-4060	1014	5	):	):	PUNCT
gs-4060	1014	6	343–50	343–50	NUM
gs-4060	1014	7	.	.	PUNCT
gs-4060	1015	1	georgian	georgian	NOUN
gs-4060	1015	2	scientists/	scientists/	NUM
gs-4060	1015	3	.	.	PUNCT
gs-4060	1016	1	7	7	NUM
gs-4060	1016	2	n	n	PRON
gs-4060	1016	3	3	3	NUM
gs-4060	1016	4	,	,	PUNCT
gs-4060	1016	5	2025	2025	NUM
gs-4060	1016	6	609	609	NUM
gs-4060	1017	1	73.aphkhazava	73.aphkhazava	NUM
gs-4060	1017	2	,	,	PUNCT
gs-4060	1017	3	david	david	PROPN
gs-4060	1017	4	,	,	PUNCT
gs-4060	1017	5	tamar	tamar	PROPN
gs-4060	1017	6	tuphinashvili	tuphinashvili	PROPN
gs-4060	1017	7	,	,	PUNCT
gs-4060	1017	8	nodar	nodar	NOUN
gs-4060	1017	9	sulashvili	sulashvili	NOUN
gs-4060	1017	10	,	,	PUNCT
gs-4060	1017	11	and	and	CCONJ
gs-4060	1017	12	maia	maia	NOUN
gs-4060	1017	13	nozadze	nozadze	NOUN
gs-4060	1017	14	.	.	PUNCT
gs-4060	1018	1	2023	2023	NUM
gs-4060	1018	2	.	.	PUNCT
gs-4060	1019	1	“	"	PUNCT
gs-4060	1019	2	the	the	DET
gs-4060	1019	3	features	feature	NOUN
gs-4060	1019	4	and	and	CCONJ
gs-4060	1019	5	role	role	NOUN
gs-4060	1019	6	of	of	ADP
gs-4060	1019	7	shp2	shp2	ADJ
gs-4060	1019	8	protein	protein	NOUN
gs-4060	1019	9	in	in	ADP
gs-4060	1019	10	postnatal	postnatal	ADJ
gs-4060	1019	11	muscle	muscle	NOUN
gs-4060	1019	12	development	development	NOUN
gs-4060	1019	13	”	"	PUNCT
gs-4060	1019	14	.	.	PUNCT
gs-4060	1020	1	scientific	scientific	ADJ
gs-4060	1020	2	journal	journal	NOUN
gs-4060	1020	3	„	„	PUNCT
gs-4060	1020	4	spectri	spectri	ADJ
gs-4060	1020	5	“	"	PUNCT
gs-4060	1020	6	1	1	NUM
gs-4060	1020	7	(	(	PUNCT
gs-4060	1020	8	march	march	PROPN
gs-4060	1020	9	)	)	PUNCT
gs-4060	1020	10	.	.	PUNCT
gs-4060	1021	1	https://doi.org/10.52340/spectri.2023.01	https://doi.org/10.52340/spectri.2023.01	PROPN
gs-4060	1021	2	.	.	PUNCT
gs-4060	1022	1	74.sulashvili	74.sulashvili	NUM
gs-4060	1022	2	n	n	CCONJ
gs-4060	1022	3	,	,	PUNCT
gs-4060	1022	4	gorgaslidze	gorgaslidze	ADJ
gs-4060	1022	5	n	n	CCONJ
gs-4060	1022	6	,	,	PUNCT
gs-4060	1022	7	gabunia	gabunia	NOUN
gs-4060	1022	8	l	l	NOUN
gs-4060	1022	9	,	,	PUNCT
gs-4060	1022	10	giorgobiani	giorgobiani	PROPN
gs-4060	1022	11	m	m	PROPN
gs-4060	1022	12	,	,	PUNCT
gs-4060	1022	13	ratiani	ratiani	PROPN
gs-4060	1022	14	l.	l.	PROPN
gs-4060	1022	15	manifestation	manifestation	PROPN
gs-4060	1022	16	of	of	ADP
gs-4060	1022	17	the	the	DET
gs-4060	1022	18	particularities	particularity	NOUN
gs-4060	1022	19	of	of	ADP
gs-4060	1022	20	the	the	DET
gs-4060	1022	21	usage	usage	NOUN
gs-4060	1022	22	features	feature	NOUN
gs-4060	1022	23	of	of	ADP
gs-4060	1022	24	monoclonal	monoclonal	NOUN
gs-4060	1022	25	antibodies	antibody	NOUN
gs-4060	1022	26	in	in	ADP
gs-4060	1022	27	various	various	ADJ
gs-4060	1022	28	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-4060	1022	29	applications	application	NOUN
gs-4060	1022	30	.	.	PUNCT
gs-4060	1023	1	jecmg	jecmg	NOUN
gs-4060	1024	1	[	[	X
gs-4060	1024	2	internet	internet	NOUN
gs-4060	1024	3	]	]	X
gs-4060	1024	4	.	.	PUNCT
gs-4060	1025	1	2023	2023	NUM
gs-4060	1025	2	nov	nov	PROPN
gs-4060	1025	3	.	.	PROPN
gs-4060	1025	4	26	26	NUM
gs-4060	1025	5	[	[	X
gs-4060	1025	6	cited	cite	VERB
gs-4060	1025	7	2025	2025	NUM
gs-4060	1025	8	jul	jul	PROPN
gs-4060	1025	9	.	.	PROPN
gs-4060	1025	10	12];(4):52	12];(4):52	NUM
gs-4060	1025	11	-	-	SYM
gs-4060	1025	12	7	7	NUM
gs-4060	1025	13	.	.	PUNCT
gs-4060	1025	14	available	available	ADJ
gs-4060	1025	15	from	from	ADP
gs-4060	1025	16	:	:	PUNCT
gs-4060	1025	17	https://journals.4science.ge/index.php/jecm/article/view/2413	https://journals.4science.ge/index.php/jecm/article/view/2413	PROPN
gs-4060	1025	18	.	.	PUNCT
gs-4060	1026	1	75.aphkhazava	75.aphkhazava	X
gs-4060	1026	2	,	,	PUNCT
gs-4060	1026	3	david	david	PROPN
gs-4060	1026	4	,	,	PUNCT
gs-4060	1026	5	nodar	nodar	PROPN
gs-4060	1026	6	sulashvili	sulashvili	NOUN
gs-4060	1026	7	,	,	PUNCT
gs-4060	1026	8	ia	ia	PROPN
gs-4060	1026	9	egnatievi	egnatievi	PROPN
gs-4060	1026	10	,	,	PUNCT
gs-4060	1026	11	manana	manana	PROPN
gs-4060	1026	12	giorgobiani	giorgobiani	PROPN
gs-4060	1026	13	,	,	PUNCT
gs-4060	1026	14	maia	maia	PROPN
gs-4060	1026	15	nozadze	nozadze	PROPN
gs-4060	1026	16	,	,	PUNCT
gs-4060	1026	17	nani	nani	PROPN
gs-4060	1026	18	vekua	vekua	NOUN
gs-4060	1026	19	,	,	PUNCT
gs-4060	1026	20	and	and	CCONJ
gs-4060	1026	21	nino	nino	PROPN
gs-4060	1026	22	japaridze	japaridze	PROPN
gs-4060	1026	23	.	.	PUNCT
gs-4060	1027	1	2024	2024	NUM
gs-4060	1027	2	.	.	PUNCT
gs-4060	1028	1	“	"	PUNCT
gs-4060	1028	2	derivation	derivation	NOUN
gs-4060	1028	3	of	of	ADP
gs-4060	1028	4	ampa	ampa	NOUN
gs-4060	1028	5	receptor	receptor	NOUN
gs-4060	1028	6	glua1	glua1	NOUN
gs-4060	1028	7	subunits	subunit	NOUN
gs-4060	1028	8	in	in	ADP
gs-4060	1028	9	mice	mouse	NOUN
gs-4060	1028	10	from	from	ADP
gs-4060	1028	11	exosomes	exosome	NOUN
gs-4060	1028	12	modulates	modulate	NOUN
gs-4060	1028	13	inflammatory	inflammatory	ADJ
gs-4060	1028	14	pain	pain	NOUN
gs-4060	1028	15	”	"	PUNCT
gs-4060	1028	16	.	.	PUNCT
gs-4060	1029	1	scientific	scientific	ADJ
gs-4060	1029	2	journal	journal	NOUN
gs-4060	1029	3	„	„	PUNCT
gs-4060	1029	4	spectri	spectri	ADJ
gs-4060	1029	5	“	"	PUNCT
gs-4060	1029	6	9	9	NUM
gs-4060	1029	7	(	(	PUNCT
gs-4060	1029	8	1	1	NUM
gs-4060	1029	9	)	)	PUNCT
gs-4060	1029	10	.	.	PUNCT
gs-4060	1030	1	https://doi.org/10.52340/spectri.2024.09.01.05	https://doi.org/10.52340/spectri.2024.09.01.05	NOUN
gs-4060	1030	2	.	.	PUNCT
gs-4060	1031	1	76.aphkhazava	76.aphkhazava	X
gs-4060	1031	2	,	,	PUNCT
gs-4060	1031	3	david	david	PROPN
gs-4060	1031	4	,	,	PUNCT
gs-4060	1031	5	nodar	nodar	PROPN
gs-4060	1031	6	sulashvili	sulashvili	NOUN
gs-4060	1031	7	,	,	PUNCT
gs-4060	1031	8	ia	ia	PROPN
gs-4060	1031	9	egnatievi	egnatievi	PROPN
gs-4060	1031	10	,	,	PUNCT
gs-4060	1031	11	tamar	tamar	PROPN
gs-4060	1031	12	tupinashvili	tupinashvili	NOUN
gs-4060	1031	13	,	,	PUNCT
gs-4060	1031	14	and	and	CCONJ
gs-4060	1031	15	maia	maia	PROPN
gs-4060	1031	16	nozadze	nozadze	PROPN
gs-4060	1031	17	.	.	PUNCT
gs-4060	1032	1	2024	2024	NUM
gs-4060	1032	2	.	.	PUNCT
gs-4060	1033	1	“	"	PUNCT
gs-4060	1033	2	dynamic	dynamic	ADJ
gs-4060	1033	3	tumor	tumor	NOUN
gs-4060	1033	4	microenvironment	microenvironment	NOUN
gs-4060	1033	5	theory	theory	NOUN
gs-4060	1033	6	:	:	PUNCT
gs-4060	1033	7	a	a	DET
gs-4060	1033	8	multifaceted	multifaceted	ADJ
gs-4060	1033	9	approach	approach	NOUN
gs-4060	1033	10	to	to	ADP
gs-4060	1033	11	tumor	tumor	NOUN
gs-4060	1033	12	research	research	NOUN
gs-4060	1033	13	and	and	CCONJ
gs-4060	1033	14	biochemistry	biochemistry	NOUN
gs-4060	1033	15	”	"	PUNCT
gs-4060	1033	16	.	.	PUNCT
gs-4060	1034	1	scientific	scientific	ADJ
gs-4060	1034	2	journal	journal	NOUN
gs-4060	1034	3	„	„	PUNCT
gs-4060	1034	4	spectri	spectri	ADJ
gs-4060	1034	5	“	"	PUNCT
gs-4060	1034	6	9	9	NUM
gs-4060	1034	7	(	(	PUNCT
gs-4060	1034	8	1	1	NUM
gs-4060	1034	9	)	)	PUNCT
gs-4060	1034	10	.	.	PUNCT
gs-4060	1035	1	https://doi.org/10.52340/spectri.2024.09.01.06	https://doi.org/10.52340/spectri.2024.09.01.06	NOUN
gs-4060	1035	2	.	.	PUNCT
gs-4060	1036	1	77.sulashvili	77.sulashvili	NUM
gs-4060	1036	2	,	,	PUNCT
gs-4060	1036	3	nodar	nodar	ADV
gs-4060	1036	4	,	,	PUNCT
gs-4060	1036	5	irine	irine	NOUN
gs-4060	1036	6	pkhakadze	pkhakadze	NOUN
gs-4060	1036	7	,	,	PUNCT
gs-4060	1036	8	margarita	margarita	PROPN
gs-4060	1036	9	beglaryan	beglaryan	NOUN
gs-4060	1036	10	,	,	PUNCT
gs-4060	1036	11	ia	ia	PROPN
gs-4060	1036	12	egnatievi	egnatievi	PROPN
gs-4060	1036	13	,	,	PUNCT
gs-4060	1036	14	manana	manana	PROPN
gs-4060	1036	15	giorgobiani	giorgobiani	PROPN
gs-4060	1036	16	,	,	PUNCT
gs-4060	1036	17	luiza	luiza	PROPN
gs-4060	1036	18	gabunia	gabunia	PROPN
gs-4060	1036	19	,	,	PUNCT
gs-4060	1036	20	nana	nana	PROPN
gs-4060	1036	21	gorgaslidze	gorgaslidze	PROPN
gs-4060	1036	22	,	,	PUNCT
gs-4060	1036	23	magda	magda	PROPN
gs-4060	1036	24	davitashvili	davitashvili	PROPN
gs-4060	1036	25	,	,	PUNCT
gs-4060	1036	26	ada	ada	PROPN
gs-4060	1036	27	(	(	PUNCT
gs-4060	1036	28	adel	adel	PROPN
gs-4060	1036	29	)	)	PUNCT
gs-4060	1036	30	tadevosyan	tadevosyan	PROPN
gs-4060	1036	31	,	,	PUNCT
gs-4060	1036	32	and	and	CCONJ
gs-4060	1036	33	lali	lali	PROPN
gs-4060	1036	34	patsia	patsia	PROPN
gs-4060	1036	35	.	.	PUNCT
gs-4060	1037	1	2025	2025	NUM
gs-4060	1037	2	.	.	PUNCT
gs-4060	1038	1	“	"	PUNCT
gs-4060	1038	2	the	the	DET
gs-4060	1038	3	scientific	scientific	ADJ
gs-4060	1038	4	discussion	discussion	NOUN
gs-4060	1038	5	of	of	ADP
gs-4060	1038	6	key	key	ADJ
gs-4060	1038	7	issue	issue	NOUN
gs-4060	1038	8	aspects	aspect	NOUN
gs-4060	1038	9	of	of	ADP
gs-4060	1038	10	modern	modern	ADJ
gs-4060	1038	11	advancing	advance	VERB
gs-4060	1038	12	innovation	innovation	NOUN
gs-4060	1038	13	of	of	ADP
gs-4060	1038	14	learning	learning	NOUN
gs-4060	1038	15	and	and	CCONJ
gs-4060	1038	16	teaching	teaching	NOUN
gs-4060	1038	17	methods	method	NOUN
gs-4060	1038	18	and	and	CCONJ
gs-4060	1038	19	pedagogical	pedagogical	ADJ
gs-4060	1038	20	approaches	approach	NOUN
gs-4060	1038	21	in	in	ADP
gs-4060	1038	22	higher	high	ADJ
gs-4060	1038	23	education	education	NOUN
gs-4060	1038	24	institutions	institution	NOUN
gs-4060	1038	25	in	in	ADP
gs-4060	1038	26	medical	medical	ADJ
gs-4060	1038	27	educational	educational	ADJ
gs-4060	1038	28	study	study	NOUN
gs-4060	1038	29	programs	program	NOUN
gs-4060	1038	30	directions	direction	VERB
gs-4060	1038	31	globally	globally	ADV
gs-4060	1038	32	in	in	ADP
gs-4060	1038	33	general	general	ADJ
gs-4060	1038	34	”	"	PUNCT
gs-4060	1038	35	.	.	PUNCT
gs-4060	1039	1	scientific	scientific	ADJ
gs-4060	1039	2	journal	journal	NOUN
gs-4060	1039	3	„	„	PUNCT
gs-4060	1039	4	spectri	spectri	ADJ
gs-4060	1039	5	“	"	PUNCT
gs-4060	1039	6	10	10	NUM
gs-4060	1039	7	(	(	PUNCT
gs-4060	1039	8	2	2	NUM
gs-4060	1039	9	)	)	PUNCT
gs-4060	1039	10	.	.	PUNCT
gs-4060	1040	1	https://doi.org/10.52340/spectri.2024.10.01.12	https://doi.org/10.52340/spectri.2024.10.01.12	PUNCT
gs-4060	1040	2	.	.	PUNCT
gs-4060	1041	1	78.gorgaslidze	78.gorgaslidze	X
gs-4060	1041	2	,	,	PUNCT
gs-4060	1041	3	nana	nana	PROPN
gs-4060	1041	4	,	,	PUNCT
gs-4060	1041	5	nodar	nodar	NOUN
gs-4060	1041	6	sulashvili	sulashvili	NOUN
gs-4060	1041	7	,	,	PUNCT
gs-4060	1041	8	luiza	luiza	PROPN
gs-4060	1041	9	gabunia	gabunia	PROPN
gs-4060	1041	10	,	,	PUNCT
gs-4060	1041	11	levan	levan	PROPN
gs-4060	1041	12	ratiani	ratiani	PROPN
gs-4060	1041	13	,	,	PUNCT
gs-4060	1041	14	and	and	CCONJ
gs-4060	1041	15	marina	marina	PROPN
gs-4060	1041	16	giorgobiani	giorgobiani	PROPN
gs-4060	1041	17	.	.	PUNCT
gs-4060	1042	1	2023	2023	NUM
gs-4060	1042	2	.	.	PUNCT
gs-4060	1043	1	“	"	PUNCT
gs-4060	1043	2	the	the	DET
gs-4060	1043	3	singularities	singularity	NOUN
gs-4060	1043	4	of	of	ADP
gs-4060	1043	5	temozolomide	temozolomide	NOUN
gs-4060	1043	6	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-4060	1043	7	effects	effect	NOUN
gs-4060	1043	8	in	in	ADP
gs-4060	1043	9	brain	brain	NOUN
gs-4060	1043	10	tumor	tumor	NOUN
gs-4060	1043	11	therapeutic	therapeutic	ADJ
gs-4060	1043	12	applications	application	NOUN
gs-4060	1043	13	”	"	PUNCT
gs-4060	1043	14	.	.	PUNCT
gs-4060	1044	1	experimental	experimental	ADJ
gs-4060	1044	2	and	and	CCONJ
gs-4060	1044	3	clinical	clinical	ADJ
gs-4060	1044	4	medicine	medicine	NOUN
gs-4060	1044	5	georgia	georgia	PROPN
gs-4060	1044	6	,	,	PUNCT
gs-4060	1044	7	no	no	INTJ
gs-4060	1044	8	.	.	NOUN
gs-4060	1044	9	4	4	NUM
gs-4060	1044	10	(	(	PUNCT
gs-4060	1044	11	november):62	november):62	NOUN
gs-4060	1044	12	-	-	PUNCT
gs-4060	1044	13	66	66	NUM
gs-4060	1044	14	.	.	PUNCT
gs-4060	1045	1	https://doi.org/10.52340/jecm.2023.04.16	https://doi.org/10.52340/jecm.2023.04.16	NUM
gs-4060	1045	2	.	.	PUNCT
gs-4060	1046	1	79.sulashvili	79.sulashvili	NUM
gs-4060	1046	2	,	,	PUNCT
gs-4060	1046	3	nodar	nodar	ADV
gs-4060	1046	4	,	,	PUNCT
gs-4060	1046	5	margarita	margarita	PROPN
gs-4060	1046	6	beglaryan	beglaryan	PROPN
gs-4060	1046	7	,	,	PUNCT
gs-4060	1046	8	nana	nana	PROPN
gs-4060	1046	9	gorgaslidze	gorgaslidze	PROPN
gs-4060	1046	10	,	,	PUNCT
gs-4060	1046	11	seyran	seyran	PROPN
gs-4060	1046	12	kocharyan	kocharyan	PROPN
gs-4060	1046	13	,	,	PUNCT
gs-4060	1046	14	naira	naira	PROPN
gs-4060	1046	15	chichoyan	chichoyan	PROPN
gs-4060	1046	16	,	,	PUNCT
gs-4060	1046	17	luiza	luiza	PROPN
gs-4060	1046	18	gabunia	gabunia	PROPN
gs-4060	1046	19	,	,	PUNCT
gs-4060	1046	20	irine	irine	NOUN
gs-4060	1046	21	zarnadze	zarnadze	PROPN
gs-4060	1046	22	,	,	PUNCT
gs-4060	1046	23	et	et	PROPN
gs-4060	1046	24	al	al	PROPN
gs-4060	1046	25	.	.	PROPN
gs-4060	1046	26	2023	2023	NUM
gs-4060	1046	27	.	.	PUNCT
gs-4060	1047	1	“	"	PUNCT
gs-4060	1047	2	the	the	DET
gs-4060	1047	3	disclosure	disclosure	NOUN
gs-4060	1047	4	of	of	ADP
gs-4060	1047	5	features	feature	NOUN
gs-4060	1047	6	,	,	PUNCT
gs-4060	1047	7	characteristics	characteristic	NOUN
gs-4060	1047	8	,	,	PUNCT
gs-4060	1047	9	possibilities	possibility	NOUN
gs-4060	1047	10	and	and	CCONJ
gs-4060	1047	11	specialties	specialty	NOUN
gs-4060	1047	12	of	of	ADP
gs-4060	1047	13	clinical	clinical	ADJ
gs-4060	1047	14	pharmacists	pharmacist	NOUN
gs-4060	1047	15	as	as	ADP
gs-4060	1047	16	mediator	mediator	NOUN
gs-4060	1047	17	among	among	ADP
gs-4060	1047	18	doctors	doctor	NOUN
gs-4060	1047	19	and	and	CCONJ
gs-4060	1047	20	patients	patient	NOUN
gs-4060	1047	21	for	for	ADP
gs-4060	1047	22	enhancement	enhancement	NOUN
gs-4060	1047	23	public	public	ADJ
gs-4060	1047	24	health	health	NOUN
gs-4060	1047	25	sector	sector	NOUN
gs-4060	1047	26	in	in	ADP
gs-4060	1047	27	a	a	DET
gs-4060	1047	28	global	global	ADJ
gs-4060	1047	29	world	world	NOUN
gs-4060	1047	30	”	"	PUNCT
gs-4060	1047	31	.	.	PUNCT
gs-4060	1048	1	experimental	experimental	ADJ
gs-4060	1048	2	and	and	CCONJ
gs-4060	1048	3	clinical	clinical	ADJ
gs-4060	1048	4	medicine	medicine	NOUN
gs-4060	1048	5	georgia	georgia	PROPN
gs-4060	1048	6	,	,	PUNCT
gs-4060	1048	7	no	no	INTJ
gs-4060	1048	8	.	.	NOUN
gs-4060	1048	9	4	4	NUM
gs-4060	1048	10	(	(	PUNCT
gs-4060	1048	11	november):57	november):57	NOUN
gs-4060	1048	12	-	-	PUNCT
gs-4060	1048	13	62	62	NUM
gs-4060	1048	14	.	.	PUNCT
gs-4060	1049	1	https://doi.org/10.52340/jecm.2023.04.15	https://doi.org/10.52340/jecm.2023.04.15	PROPN
gs-4060	1049	2	.	.	PUNCT
gs-4060	1050	1	80.sulashvili	80.sulashvili	NUM
gs-4060	1050	2	,	,	PUNCT
gs-4060	1050	3	nodar	nodar	INTJ
gs-4060	1050	4	,	,	PUNCT
gs-4060	1050	5	nato	nato	PROPN
gs-4060	1050	6	alavidze	alavidze	PROPN
gs-4060	1050	7	,	,	PUNCT
gs-4060	1050	8	maka	maka	PROPN
gs-4060	1050	9	buleishvili	buleishvili	PROPN
gs-4060	1050	10	,	,	PUNCT
gs-4060	1050	11	vira	vira	PROPN
gs-4060	1050	12	kravchenko	kravchenko	PROPN
gs-4060	1050	13	,	,	PUNCT
gs-4060	1050	14	marika	marika	PROPN
gs-4060	1050	15	sulashvili	sulashvili	PROPN
gs-4060	1050	16	,	,	PUNCT
gs-4060	1050	17	igor	igor	NOUN
gs-4060	1050	18	seniuk	seniuk	NOUN
gs-4060	1050	19	,	,	PUNCT
gs-4060	1050	20	tamar	tamar	PROPN
gs-4060	1050	21	okropiridze	okropiridze	PROPN
gs-4060	1050	22	,	,	PUNCT
gs-4060	1050	23	marina	marina	PROPN
gs-4060	1050	24	giorgobiani	giorgobiani	PROPN
gs-4060	1050	25	,	,	PUNCT
gs-4060	1050	26	lela	lela	PROPN
gs-4060	1050	27	grigolia	grigolia	PROPN
gs-4060	1050	28	,	,	PUNCT
gs-4060	1050	29	and	and	CCONJ
gs-4060	1050	30	kakhaber	kakhaber	PROPN
gs-4060	1050	31	robakidze	robakidze	NOUN
gs-4060	1050	32	.	.	PUNCT
gs-4060	1051	1	2025	2025	NUM
gs-4060	1051	2	.	.	PUNCT
gs-4060	1052	1	“	"	PUNCT
gs-4060	1052	2	the	the	DET
gs-4060	1052	3	manifestation	manifestation	NOUN
gs-4060	1052	4	of	of	ADP
gs-4060	1052	5	key	key	ADJ
gs-4060	1052	6	issue	issue	NOUN
gs-4060	1052	7	features	feature	NOUN
gs-4060	1052	8	of	of	ADP
gs-4060	1052	9	global	global	ADJ
gs-4060	1052	10	perspectives	perspective	NOUN
gs-4060	1052	11	on	on	ADP
gs-4060	1052	12	innovative	innovative	ADJ
gs-4060	1052	13	teaching	teaching	NOUN
gs-4060	1052	14	and	and	CCONJ
gs-4060	1052	15	learning	learn	VERB
gs-4060	1052	16	approach	approach	NOUN
gs-4060	1052	17	strategies	strategy	NOUN
gs-4060	1052	18	in	in	ADP
gs-4060	1052	19	higher	high	ADJ
gs-4060	1052	20	medical	medical	ADJ
gs-4060	1052	21	education	education	NOUN
gs-4060	1052	22	:	:	PUNCT
gs-4060	1052	23	advancing	advance	VERB
gs-4060	1052	24	student	student	NOUN
gs-4060	1052	25	-	-	PUNCT
gs-4060	1052	26	centered	center	VERB
gs-4060	1052	27	practices	practice	NOUN
gs-4060	1052	28	,	,	PUNCT
gs-4060	1052	29	technology	technology	NOUN
gs-4060	1052	30	integration	integration	NOUN
gs-4060	1052	31	and	and	CCONJ
gs-4060	1052	32	competency	competency	NOUN
gs-4060	1052	33	-	-	PUNCT
gs-4060	1052	34	based	base	VERB
gs-4060	1052	35	frameworks	framework	NOUN
gs-4060	1052	36	”	"	PUNCT
gs-4060	1052	37	.	.	PUNCT
gs-4060	1053	1	scientific	scientific	ADJ
gs-4060	1053	2	journal	journal	NOUN
gs-4060	1053	3	„	„	PUNCT
gs-4060	1053	4	spectri	spectri	ADJ
gs-4060	1053	5	“	"	PUNCT
gs-4060	1053	6	10	10	NUM
gs-4060	1053	7	(	(	PUNCT
gs-4060	1053	8	2	2	NUM
gs-4060	1053	9	)	)	PUNCT
gs-4060	1053	10	.	.	PUNCT
gs-4060	1054	1	https://doi.org/10.52340/spectri.2024.10.01.11	https://doi.org/10.52340/spectri.2024.10.01.11	X
gs-4060	1054	2	.	.	PUNCT
gs-4060	1055	1	georgian	georgian	NOUN
gs-4060	1055	2	scientists/	scientists/	NUM
gs-4060	1055	3	.	.	PUNCT
gs-4060	1056	1	7	7	NUM
gs-4060	1056	2	n	n	PRON
gs-4060	1056	3	3	3	NUM
gs-4060	1056	4	,	,	PUNCT
gs-4060	1056	5	2025	2025	NUM
gs-4060	1056	6	610	610	NUM
gs-4060	1056	7	81.sulashvili	81.sulashvili	NUM
gs-4060	1056	8	,	,	PUNCT
gs-4060	1056	9	nodar	nodar	ADV
gs-4060	1056	10	,	,	PUNCT
gs-4060	1056	11	nana	nana	PROPN
gs-4060	1056	12	gorgaslidze	gorgaslidze	PROPN
gs-4060	1056	13	,	,	PUNCT
gs-4060	1056	14	margarita	margarita	PROPN
gs-4060	1056	15	beglaryan	beglaryan	PROPN
gs-4060	1056	16	,	,	PUNCT
gs-4060	1056	17	luiza	luiza	PROPN
gs-4060	1056	18	gabunia	gabunia	PROPN
gs-4060	1056	19	,	,	PUNCT
gs-4060	1056	20	natia	natia	PROPN
gs-4060	1056	21	kvizhinadze	kvizhinadze	PROPN
gs-4060	1056	22	,	,	PUNCT
gs-4060	1056	23	tea	tea	NOUN
gs-4060	1056	24	zarkua	zarkua	NOUN
gs-4060	1056	25	,	,	PUNCT
gs-4060	1056	26	marina	marina	NOUN
gs-4060	1056	27	giorgobiani	giorgobiani	PROPN
gs-4060	1056	28	,	,	PUNCT
gs-4060	1056	29	nana	nana	PROPN
gs-4060	1056	30	peikrishvili	peikrishvili	NOUN
gs-4060	1056	31	,	,	PUNCT
gs-4060	1056	32	and	and	CCONJ
gs-4060	1056	33	marika	marika	PROPN
gs-4060	1056	34	sulashvili	sulashvili	PROPN
gs-4060	1056	35	.	.	PUNCT
gs-4060	1057	1	2024	2024	NUM
gs-4060	1057	2	.	.	PUNCT
gs-4060	1058	1	“	"	PUNCT
gs-4060	1058	2	the	the	DET
gs-4060	1058	3	manifestation	manifestation	NOUN
gs-4060	1058	4	of	of	ADP
gs-4060	1058	5	characteristics	characteristic	NOUN
gs-4060	1058	6	,	,	PUNCT
gs-4060	1058	7	opportunities	opportunity	NOUN
gs-4060	1058	8	and	and	CCONJ
gs-4060	1058	9	challenges	challenge	NOUN
gs-4060	1058	10	of	of	ADP
gs-4060	1058	11	electronic	electronic	ADJ
gs-4060	1058	12	systems	system	NOUN
gs-4060	1058	13	and	and	CCONJ
gs-4060	1058	14	digital	digital	ADJ
gs-4060	1058	15	intelligence	intelligence	NOUN
gs-4060	1058	16	using	use	VERB
gs-4060	1058	17	in	in	ADP
gs-4060	1058	18	pharmaceutical	pharmaceutical	ADJ
gs-4060	1058	19	services	service	NOUN
gs-4060	1058	20	”	"	PUNCT
gs-4060	1058	21	.	.	PUNCT
gs-4060	1059	1	experimental	experimental	ADJ
gs-4060	1059	2	and	and	CCONJ
gs-4060	1059	3	clinical	clinical	ADJ
gs-4060	1059	4	medicine	medicine	NOUN
gs-4060	1059	5	georgia	georgia	PROPN
gs-4060	1059	6	,	,	PUNCT
gs-4060	1059	7	no	no	INTJ
gs-4060	1059	8	.	.	NOUN
gs-4060	1059	9	4	4	NUM
gs-4060	1059	10	(	(	PUNCT
gs-4060	1059	11	september):122	september):122	PROPN
gs-4060	1059	12	-	-	PUNCT
gs-4060	1059	13	25	25	NUM
gs-4060	1059	14	.	.	PUNCT
gs-4060	1060	1	https://doi.org/10.52340/jecm.2024.04.33	https://doi.org/10.52340/jecm.2024.04.33	PROPN
gs-4060	1060	2	.	.	PROPN
gs-4060	1061	1	82.sulashvili	82.sulashvili	NUM
gs-4060	1061	2	n	n	CCONJ
gs-4060	1061	3	,	,	PUNCT
gs-4060	1061	4	davitashvili	davitashvili	NOUN
gs-4060	1061	5	m	m	PROPN
gs-4060	1061	6	,	,	PUNCT
gs-4060	1061	7	gorgaslidze	gorgaslidze	ADJ
gs-4060	1061	8	n	n	CCONJ
gs-4060	1061	9	,	,	PUNCT
gs-4060	1061	10	gabunia	gabunia	NOUN
gs-4060	1061	11	l	l	NOUN
gs-4060	1061	12	,	,	PUNCT
gs-4060	1061	13	beglaryan	beglaryan	PROPN
gs-4060	1061	14	m	m	PROPN
gs-4060	1061	15	,	,	PUNCT
gs-4060	1061	16	alavidze	alavidze	PROPN
gs-4060	1061	17	n	n	CCONJ
gs-4060	1061	18	,	,	PUNCT
gs-4060	1061	19	et	et	PROPN
gs-4060	1061	20	al	al	PROPN
gs-4060	1061	21	.	.	PUNCT
gs-4060	1062	1	the	the	DET
gs-4060	1062	2	scientific	scientific	ADJ
gs-4060	1062	3	discussion	discussion	NOUN
gs-4060	1062	4	of	of	ADP
gs-4060	1062	5	some	some	DET
gs-4060	1062	6	issues	issue	NOUN
gs-4060	1062	7	of	of	ADP
gs-4060	1062	8	features	feature	NOUN
gs-4060	1062	9	and	and	CCONJ
gs-4060	1062	10	challenges	challenge	NOUN
gs-4060	1062	11	of	of	ADP
gs-4060	1062	12	using	use	VERB
gs-4060	1062	13	of	of	ADP
gs-4060	1062	14	car	car	NOUN
gs-4060	1062	15	-	-	PUNCT
gs-4060	1062	16	t	t	NOUN
gs-4060	1062	17	cells	cell	NOUN
gs-4060	1062	18	in	in	ADP
gs-4060	1062	19	immunotherapy	immunotherapy	NOUN
gs-4060	1062	20	.	.	PUNCT
gs-4060	1063	1	gs	gs	X
gs-4060	1064	1	[	[	X
gs-4060	1064	2	internet	internet	NOUN
gs-4060	1064	3	]	]	PUNCT
gs-4060	1064	4	.	.	PUNCT
gs-4060	1065	1	2024	2024	NUM
gs-4060	1065	2	nov	nov	PROPN
gs-4060	1065	3	.	.	PROPN
gs-4060	1065	4	26	26	NUM
gs-4060	1065	5	[	[	X
gs-4060	1065	6	cited	cite	VERB
gs-4060	1065	7	2025	2025	NUM
gs-4060	1065	8	jul	jul	PROPN
gs-4060	1065	9	.	.	PUNCT
gs-4060	1065	10	12];6(4):263	12];6(4):263	NUM
gs-4060	1065	11	-	-	SYM
gs-4060	1065	12	90	90	NUM
gs-4060	1065	13	.	.	PUNCT
gs-4060	1066	1	available	available	ADJ
gs-4060	1066	2	from	from	ADP
gs-4060	1066	3	:	:	PUNCT
gs-4060	1066	4	https://journals.4science.ge/index.php/gs/article/view/3214	https://journals.4science.ge/index.php/gs/article/view/3214	NOUN
gs-4060	1066	5	.	.	PUNCT
gs-4060	1067	1	83.sulashvili	83.sulashvili	NUM
gs-4060	1067	2	,	,	PUNCT
gs-4060	1067	3	nodar	nodar	ADV
gs-4060	1067	4	,	,	PUNCT
gs-4060	1067	5	udgam	udgam	NOUN
gs-4060	1067	6	yaduvanshi	yaduvanshi	PROPN
gs-4060	1067	7	,	,	PUNCT
gs-4060	1067	8	mohini	mohini	PROPN
gs-4060	1067	9	yadav	yadav	PROPN
gs-4060	1067	10	,	,	PUNCT
gs-4060	1067	11	luiza	luiza	PROPN
gs-4060	1067	12	gabunia	gabunia	PROPN
gs-4060	1067	13	,	,	PUNCT
gs-4060	1067	14	ketevan	ketevan	PROPN
gs-4060	1067	15	ghambashidze	ghambashidze	PROPN
gs-4060	1067	16	,	,	PUNCT
gs-4060	1067	17	nana	nana	PROPN
gs-4060	1067	18	gorgaslidze	gorgaslidze	PROPN
gs-4060	1067	19	,	,	PUNCT
gs-4060	1067	20	margarita	margarita	PROPN
gs-4060	1067	21	beglaryan	beglaryan	PROPN
gs-4060	1067	22	,	,	PUNCT
gs-4060	1067	23	et	et	PROPN
gs-4060	1067	24	al	al	PROPN
gs-4060	1067	25	.	.	PROPN
gs-4060	1067	26	2025	2025	NUM
gs-4060	1067	27	.	.	PUNCT
gs-4060	1068	1	“	"	PUNCT
gs-4060	1068	2	the	the	DET
gs-4060	1068	3	scientific	scientific	ADJ
gs-4060	1068	4	discourse	discourse	NOUN
gs-4060	1068	5	of	of	ADP
gs-4060	1068	6	features	feature	NOUN
gs-4060	1068	7	of	of	ADP
gs-4060	1068	8	clinical	clinical	ADJ
gs-4060	1068	9	use	use	NOUN
gs-4060	1068	10	and	and	CCONJ
gs-4060	1068	11	pharmacology	pharmacology	NOUN
gs-4060	1068	12	of	of	ADP
gs-4060	1068	13	vasoconstrictors	vasoconstrictor	NOUN
gs-4060	1068	14	and	and	CCONJ
gs-4060	1068	15	their	their	PRON
gs-4060	1068	16	impact	impact	NOUN
gs-4060	1068	17	on	on	ADP
gs-4060	1068	18	cardiac	cardiac	ADJ
gs-4060	1068	19	function	function	NOUN
gs-4060	1068	20	”	"	PUNCT
gs-4060	1068	21	.	.	PUNCT
gs-4060	1069	1	junior	junior	ADJ
gs-4060	1069	2	researchers	researcher	NOUN
gs-4060	1069	3	3	3	NUM
gs-4060	1069	4	(	(	PUNCT
gs-4060	1069	5	1):28	1):28	NUM
gs-4060	1069	6	-	-	SYM
gs-4060	1069	7	68	68	NUM
gs-4060	1069	8	.	.	PUNCT
gs-4060	1070	1	https://doi.org/10.52340/jr.2025.03.01.02	https://doi.org/10.52340/jr.2025.03.01.02	X
gs-4060	1070	2	.	.	PROPN
gs-4060	1070	3	84.sulashvili	84.sulashvili	NUM
gs-4060	1071	1	n	n	CCONJ
gs-4060	1071	2	,	,	PUNCT
gs-4060	1072	1	nimangre	nimangre	PROPN
gs-4060	1072	2	rr	rr	PROPN
gs-4060	1072	3	.	.	PUNCT
gs-4060	1073	1	manifestation	manifestation	NOUN
gs-4060	1073	2	of	of	ADP
gs-4060	1073	3	some	some	DET
gs-4060	1073	4	aspects	aspect	NOUN
gs-4060	1073	5	of	of	ADP
gs-4060	1073	6	cardiovascular	cardiovascular	ADJ
gs-4060	1073	7	diseases	disease	NOUN
gs-4060	1073	8	,	,	PUNCT
gs-4060	1073	9	implications	implication	NOUN
gs-4060	1073	10	,	,	PUNCT
gs-4060	1073	11	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-4060	1073	12	strategies	strategy	NOUN
gs-4060	1073	13	,	,	PUNCT
gs-4060	1073	14	effects	effect	NOUN
gs-4060	1073	15	,	,	PUNCT
gs-4060	1073	16	impacts	impact	NOUN
gs-4060	1073	17	and	and	CCONJ
gs-4060	1073	18	potential	potential	ADJ
gs-4060	1073	19	hazards	hazard	NOUN
gs-4060	1073	20	in	in	ADP
gs-4060	1073	21	general	general	ADJ
gs-4060	1073	22	.	.	PUNCT
gs-4060	1074	1	jr	jr	PROPN
gs-4060	1075	1	[	[	X
gs-4060	1075	2	internet	internet	NOUN
gs-4060	1075	3	]	]	PUNCT
gs-4060	1075	4	.	.	PUNCT
gs-4060	1076	1	2025	2025	NUM
gs-4060	1076	2	feb	feb	X
gs-4060	1076	3	.	.	PROPN
gs-4060	1076	4	7	7	NUM
gs-4060	1076	5	[	[	X
gs-4060	1076	6	cited	cite	VERB
gs-4060	1076	7	2025	2025	NUM
gs-4060	1076	8	jul	jul	PROPN
gs-4060	1076	9	.	.	PUNCT
gs-4060	1077	1	12];3(1):1	12];3(1):1	NUM
gs-4060	1077	2	-	-	SYM
gs-4060	1077	3	27	27	NUM
gs-4060	1077	4	.	.	PUNCT
gs-4060	1078	1	available	available	ADJ
gs-4060	1078	2	from	from	ADP
gs-4060	1078	3	:	:	PUNCT
gs-4060	1078	4	https://journals.4science.ge/index.php/jr/article/view/3393	https://journals.4science.ge/index.php/jr/article/view/3393	PROPN
gs-4060	1078	5	.	.	PUNCT
gs-4060	1079	1	85.gorgaslidze	85.gorgaslidze	NUM
gs-4060	1079	2	,	,	PUNCT
gs-4060	1079	3	nana	nana	PROPN
gs-4060	1079	4	,	,	PUNCT
gs-4060	1079	5	nodar	nodar	NOUN
gs-4060	1079	6	sulashvili	sulashvili	NOUN
gs-4060	1079	7	,	,	PUNCT
gs-4060	1079	8	luiza	luiza	PROPN
gs-4060	1079	9	gabunia	gabunia	PROPN
gs-4060	1079	10	,	,	PUNCT
gs-4060	1079	11	shafiga	shafiga	PROPN
gs-4060	1079	12	topchiyeva	topchiyeva	PROPN
gs-4060	1079	13	,	,	PUNCT
gs-4060	1079	14	vira	vira	PROPN
gs-4060	1079	15	kravchenko	kravchenko	PROPN
gs-4060	1079	16	,	,	PUNCT
gs-4060	1079	17	marina	marina	PROPN
gs-4060	1079	18	giorgobiani	giorgobiani	PROPN
gs-4060	1079	19	,	,	PUNCT
gs-4060	1079	20	irina	irina	PROPN
gs-4060	1079	21	zarnadze	zarnadze	PROPN
gs-4060	1079	22	,	,	PUNCT
gs-4060	1079	23	and	and	CCONJ
gs-4060	1079	24	igor	igor	NOUN
gs-4060	1079	25	seniuk	seniuk	NOUN
gs-4060	1079	26	.	.	PUNCT
gs-4060	1080	1	2024	2024	NUM
gs-4060	1080	2	.	.	PUNCT
gs-4060	1081	1	“	"	PUNCT
gs-4060	1081	2	manifestation	manifestation	NOUN
gs-4060	1081	3	of	of	ADP
gs-4060	1081	4	some	some	DET
gs-4060	1081	5	key	key	ADJ
gs-4060	1081	6	issue	issue	NOUN
gs-4060	1081	7	aspects	aspect	NOUN
gs-4060	1081	8	of	of	ADP
gs-4060	1081	9	features	feature	NOUN
gs-4060	1081	10	of	of	ADP
gs-4060	1081	11	medicines	medicine	NOUN
gs-4060	1081	12	turnover	turnover	NOUN
gs-4060	1081	13	and	and	CCONJ
gs-4060	1081	14	its	its	PRON
gs-4060	1081	15	influence	influence	NOUN
gs-4060	1081	16	on	on	ADP
gs-4060	1081	17	environment	environment	NOUN
gs-4060	1081	18	and	and	CCONJ
gs-4060	1081	19	medicalecological	medicalecological	ADJ
gs-4060	1081	20	safety	safety	NOUN
gs-4060	1081	21	challenges	challenge	NOUN
gs-4060	1081	22	globally	globally	ADV
gs-4060	1081	23	”	"	PUNCT
gs-4060	1081	24	.	.	PUNCT
gs-4060	1082	1	experimental	experimental	ADJ
gs-4060	1082	2	and	and	CCONJ
gs-4060	1082	3	clinical	clinical	ADJ
gs-4060	1082	4	medicine	medicine	NOUN
gs-4060	1082	5	georgia	georgia	PROPN
gs-4060	1082	6	,	,	PUNCT
gs-4060	1082	7	no	no	INTJ
gs-4060	1082	8	.	.	NOUN
gs-4060	1082	9	4	4	NUM
gs-4060	1082	10	(	(	PUNCT
gs-4060	1082	11	september):130	september):130	PROPN
gs-4060	1082	12	-	-	PUNCT
gs-4060	1082	13	32	32	NUM
gs-4060	1082	14	.	.	PUNCT
gs-4060	1083	1	https://doi.org/10.52340/jecm.2024.04.35	https://doi.org/10.52340/jecm.2024.04.35	PROPN
gs-4060	1083	2	.	.	PUNCT
gs-4060	1084	1	86.sulashvili	86.sulashvili	NUM
gs-4060	1084	2	,	,	PUNCT
gs-4060	1084	3	nodar	nodar	ADJ
gs-4060	1084	4	,	,	PUNCT
gs-4060	1084	5	margarita	margarita	PROPN
gs-4060	1084	6	beglaryan	beglaryan	PROPN
gs-4060	1084	7	,	,	PUNCT
gs-4060	1084	8	nana	nana	PROPN
gs-4060	1084	9	gorgaslidze	gorgaslidze	PROPN
gs-4060	1084	10	,	,	PUNCT
gs-4060	1084	11	seyran	seyran	PROPN
gs-4060	1084	12	kocharyan	kocharyan	PROPN
gs-4060	1084	13	,	,	PUNCT
gs-4060	1084	14	naira	naira	PROPN
gs-4060	1084	15	chichoyan	chichoyan	PROPN
gs-4060	1084	16	,	,	PUNCT
gs-4060	1084	17	luiza	luiza	PROPN
gs-4060	1084	18	gabunia	gabunia	PROPN
gs-4060	1084	19	,	,	PUNCT
gs-4060	1084	20	natia	natia	PROPN
gs-4060	1084	21	kvizhinadze	kvizhinadze	PROPN
gs-4060	1084	22	,	,	PUNCT
gs-4060	1084	23	et	et	PROPN
gs-4060	1084	24	al	al	PROPN
gs-4060	1084	25	.	.	PROPN
gs-4060	1084	26	2024	2024	NUM
gs-4060	1084	27	.	.	PUNCT
gs-4060	1085	1	“	"	PUNCT
gs-4060	1085	2	the	the	DET
gs-4060	1085	3	scientific	scientific	ADJ
gs-4060	1085	4	discussion	discussion	NOUN
gs-4060	1085	5	of	of	ADP
gs-4060	1085	6	some	some	DET
gs-4060	1085	7	key	key	ADJ
gs-4060	1085	8	issue	issue	NOUN
gs-4060	1085	9	aspects	aspect	NOUN
gs-4060	1085	10	of	of	ADP
gs-4060	1085	11	pharmacists	pharmacist	NOUN
gs-4060	1085	12	’	’	PART
gs-4060	1085	13	vocational	vocational	ADJ
gs-4060	1085	14	challenges	challenge	NOUN
gs-4060	1085	15	,	,	PUNCT
gs-4060	1085	16	vision	vision	NOUN
gs-4060	1085	17	,	,	PUNCT
gs-4060	1085	18	opportunities	opportunity	NOUN
gs-4060	1085	19	,	,	PUNCT
gs-4060	1085	20	outlooks	outlook	NOUN
gs-4060	1085	21	,	,	PUNCT
gs-4060	1085	22	objections	objection	NOUN
gs-4060	1085	23	,	,	PUNCT
gs-4060	1085	24	appearances	appearance	NOUN
gs-4060	1085	25	and	and	CCONJ
gs-4060	1085	26	indentation	indentation	NOUN
gs-4060	1085	27	in	in	ADP
gs-4060	1085	28	general	general	ADJ
gs-4060	1085	29	and	and	CCONJ
gs-4060	1085	30	public	public	ADJ
gs-4060	1085	31	health	health	NOUN
gs-4060	1085	32	care	care	NOUN
gs-4060	1085	33	direction	direction	NOUN
gs-4060	1085	34	”	"	PUNCT
gs-4060	1085	35	.	.	PUNCT
gs-4060	1086	1	experimental	experimental	ADJ
gs-4060	1086	2	and	and	CCONJ
gs-4060	1086	3	clinical	clinical	ADJ
gs-4060	1086	4	medicine	medicine	NOUN
gs-4060	1086	5	georgia	georgia	PROPN
gs-4060	1086	6	,	,	PUNCT
gs-4060	1086	7	no	no	INTJ
gs-4060	1086	8	.	.	NOUN
gs-4060	1086	9	4	4	NUM
gs-4060	1086	10	(	(	PUNCT
gs-4060	1086	11	september):126	september):126	PROPN
gs-4060	1086	12	-	-	PUNCT
gs-4060	1086	13	29	29	NUM
gs-4060	1086	14	.	.	PUNCT
gs-4060	1087	1	https://doi.org/10.52340/jecm.2024.04.34	https://doi.org/10.52340/jecm.2024.04.34	PROPN
gs-4060	1087	2	.	.	PUNCT
gs-4060	1088	1	87.aphkhazava	87.aphkhazava	NUM
gs-4060	1088	2	,	,	PUNCT
gs-4060	1088	3	david	david	PROPN
gs-4060	1088	4	,	,	PUNCT
gs-4060	1088	5	nodar	nodar	PROPN
gs-4060	1088	6	sulashvili	sulashvili	NOUN
gs-4060	1088	7	,	,	PUNCT
gs-4060	1088	8	tamar	tamar	PROPN
gs-4060	1088	9	tupinashvili	tupinashvili	NOUN
gs-4060	1088	10	,	,	PUNCT
gs-4060	1088	11	and	and	CCONJ
gs-4060	1088	12	maia	maia	PROPN
gs-4060	1088	13	nozadze	nozadze	PROPN
gs-4060	1088	14	.	.	PUNCT
gs-4060	1089	1	2024	2024	NUM
gs-4060	1089	2	.	.	PUNCT
gs-4060	1090	1	“	"	PUNCT
gs-4060	1090	2	dynamic	dynamic	ADJ
gs-4060	1090	3	cellular	cellular	ADJ
gs-4060	1090	4	equilibrium	equilibrium	NOUN
gs-4060	1090	5	theory	theory	NOUN
gs-4060	1090	6	of	of	ADP
gs-4060	1090	7	aging	aging	NOUN
gs-4060	1090	8	:	:	PUNCT
gs-4060	1090	9	integrating	integrate	VERB
gs-4060	1090	10	maintenance	maintenance	NOUN
gs-4060	1090	11	and	and	CCONJ
gs-4060	1090	12	accumulation	accumulation	NOUN
gs-4060	1090	13	in	in	ADP
gs-4060	1090	14	the	the	DET
gs-4060	1090	15	aging	age	VERB
gs-4060	1090	16	process	process	NOUN
gs-4060	1090	17	”	"	PUNCT
gs-4060	1090	18	.	.	PUNCT
gs-4060	1091	1	scientific	scientific	ADJ
gs-4060	1091	2	journal	journal	NOUN
gs-4060	1091	3	„	„	PUNCT
gs-4060	1091	4	spectri“8	spectri“8	ADJ
gs-4060	1091	5	(	(	PUNCT
gs-4060	1091	6	2	2	NUM
gs-4060	1091	7	)	)	PUNCT
gs-4060	1091	8	.	.	PUNCT
gs-4060	1092	1	https://doi.org/10.52340/spectri.2023.08.02.03	https://doi.org/10.52340/spectri.2023.08.02.03	X
gs-4060	1092	2	.	.	PUNCT
gs-4060	1092	3	88.alexander	88.alexander	NUM
gs-4060	1092	4	jl	jl	PROPN
gs-4060	1092	5	,	,	PUNCT
gs-4060	1092	6	wilson	wilson	PROPN
gs-4060	1092	7	i	i	PROPN
gs-4060	1092	8	d	d	PROPN
gs-4060	1092	9	,	,	PUNCT
gs-4060	1092	10	teare	teare	VERB
gs-4060	1092	11	j	j	PROPN
gs-4060	1092	12	,	,	PUNCT
gs-4060	1092	13	marchesi	marchesi	PROPN
gs-4060	1092	14	jr	jr	PROPN
gs-4060	1092	15	,	,	PUNCT
gs-4060	1092	16	nicholson	nicholson	PROPN
gs-4060	1092	17	jk	jk	PROPN
gs-4060	1092	18	,	,	PUNCT
gs-4060	1092	19	kinross	kinross	PROPN
gs-4060	1092	20	jm	jm	PROPN
gs-4060	1092	21	.	.	PROPN
gs-4060	1093	1	gut	gut	VERB
gs-4060	1093	2	microbiota	microbiota	NOUN
gs-4060	1093	3	modulation	modulation	NOUN
gs-4060	1093	4	of	of	ADP
gs-4060	1093	5	chemotherapy	chemotherapy	NOUN
gs-4060	1093	6	efficacy	efficacy	NOUN
gs-4060	1093	7	and	and	CCONJ
gs-4060	1093	8	toxicity	toxicity	NOUN
gs-4060	1093	9	.	.	PUNCT
gs-4060	1094	1	nat	nat	PROPN
gs-4060	1094	2	rev	rev	PROPN
gs-4060	1094	3	gastroenterol	gastroenterol	NOUN
gs-4060	1094	4	hepatol	hepatol	ADV
gs-4060	1094	5	.	.	PUNCT
gs-4060	1095	1	2017;14(6):356	2017;14(6):356	NOUN
gs-4060	1095	2	-	-	SYM
gs-4060	1095	3	65	65	NUM
gs-4060	1095	4	.	.	PUNCT
gs-4060	1096	1	89.wallace	89.wallace	NUM
gs-4060	1097	1	bd	bd	PROPN
gs-4060	1097	2	,	,	PUNCT
gs-4060	1097	3	wang	wang	PROPN
gs-4060	1097	4	h	h	PROPN
gs-4060	1097	5	,	,	PUNCT
gs-4060	1097	6	lane	lane	PROPN
gs-4060	1097	7	kt	kt	PROPN
gs-4060	1097	8	,	,	PUNCT
gs-4060	1097	9	scott	scott	PROPN
gs-4060	1097	10	je	je	PROPN
gs-4060	1097	11	,	,	PUNCT
gs-4060	1097	12	orans	orans	PROPN
gs-4060	1097	13	j	j	PROPN
gs-4060	1097	14	,	,	PUNCT
gs-4060	1097	15	koo	koo	PROPN
gs-4060	1097	16	js	js	PROPN
gs-4060	1097	17	,	,	PUNCT
gs-4060	1097	18	et	et	PROPN
gs-4060	1097	19	al	al	PROPN
gs-4060	1097	20	.	.	PUNCT
gs-4060	1097	21	alleviating	alleviate	VERB
gs-4060	1097	22	cancer	cancer	NOUN
gs-4060	1097	23	drug	drug	NOUN
gs-4060	1097	24	toxicity	toxicity	NOUN
gs-4060	1097	25	by	by	ADP
gs-4060	1097	26	inhibiting	inhibit	VERB
gs-4060	1097	27	a	a	DET
gs-4060	1097	28	bacterial	bacterial	ADJ
gs-4060	1097	29	enzyme	enzyme	NOUN
gs-4060	1097	30	.	.	PUNCT
gs-4060	1098	1	science	science	NOUN
gs-4060	1098	2	.	.	PUNCT
gs-4060	1099	1	2010;330(6005):831	2010;330(6005):831	NUM
gs-4060	1099	2	-	-	SYM
gs-4060	1099	3	5	5	NUM
gs-4060	1099	4	.	.	PUNCT
gs-4060	1099	5	90.le	90.le	NUM
gs-4060	1099	6	dt	dt	PROPN
gs-4060	1099	7	,	,	PUNCT
gs-4060	1099	8	uram	uram	PROPN
gs-4060	1099	9	jn	jn	PROPN
gs-4060	1099	10	,	,	PUNCT
gs-4060	1099	11	wang	wang	PROPN
gs-4060	1099	12	h	h	PROPN
gs-4060	1099	13	,	,	PUNCT
gs-4060	1099	14	bartlett	bartlett	PROPN
gs-4060	1099	15	br	br	PROPN
gs-4060	1099	16	,	,	PUNCT
gs-4060	1099	17	kemberling	kemberle	VERB
gs-4060	1099	18	h	h	NOUN
gs-4060	1099	19	,	,	PUNCT
gs-4060	1099	20	eyring	eyre	VERB
gs-4060	1099	21	ad	ad	NOUN
gs-4060	1099	22	,	,	PUNCT
gs-4060	1099	23	et	et	PROPN
gs-4060	1099	24	al	al	PROPN
gs-4060	1099	25	.	.	PROPN
gs-4060	1099	26	pd-1	pd-1	ADP
gs-4060	1099	27	blockade	blockade	NOUN
gs-4060	1099	28	in	in	ADP
gs-4060	1099	29	tumors	tumor	NOUN
gs-4060	1099	30	with	with	ADP
gs-4060	1099	31	mismatch	mismatch	ADJ
gs-4060	1099	32	-	-	PUNCT
gs-4060	1099	33	repair	repair	NOUN
gs-4060	1099	34	deficiency	deficiency	NOUN
gs-4060	1099	35	.	.	PUNCT
gs-4060	1100	1	n	n	CCONJ
gs-4060	1100	2	engl	engl	PROPN
gs-4060	1100	3	j	j	PROPN
gs-4060	1100	4	med	med	PROPN
gs-4060	1100	5	.	.	PUNCT
gs-4060	1101	1	2015;372(26):2509	2015;372(26):2509	NUM
gs-4060	1101	2	-	-	SYM
gs-4060	1101	3	20	20	NUM
gs-4060	1101	4	.	.	PUNCT
gs-4060	1102	1	georgian	georgian	NOUN
gs-4060	1102	2	scientists/	scientists/	NUM
gs-4060	1102	3	.	.	PUNCT
gs-4060	1103	1	7	7	NUM
gs-4060	1103	2	n	n	PRON
gs-4060	1103	3	3	3	NUM
gs-4060	1103	4	,	,	PUNCT
gs-4060	1103	5	2025	2025	NUM
gs-4060	1103	6	611	611	NUM
gs-4060	1103	7	91.marcus	91.marcus	NUM
gs-4060	1103	8	l	l	NOUN
gs-4060	1103	9	,	,	PUNCT
gs-4060	1103	10	lemery	lemery	PROPN
gs-4060	1103	11	sj	sj	PROPN
gs-4060	1103	12	,	,	PUNCT
gs-4060	1103	13	keegan	keegan	PROPN
gs-4060	1103	14	p	p	PROPN
gs-4060	1103	15	,	,	PUNCT
gs-4060	1103	16	pazdur	pazdur	PROPN
gs-4060	1103	17	r.	r.	PROPN
gs-4060	1103	18	fda	fda	PROPN
gs-4060	1103	19	approval	approval	PROPN
gs-4060	1103	20	summary	summary	NOUN
gs-4060	1103	21	:	:	PUNCT
gs-4060	1103	22	pembrolizumab	pembrolizumab	NOUN
gs-4060	1103	23	for	for	ADP
gs-4060	1103	24	the	the	DET
gs-4060	1103	25	treatment	treatment	NOUN
gs-4060	1103	26	of	of	ADP
gs-4060	1103	27	microsatellite	microsatellite	ADJ
gs-4060	1103	28	instability	instability	NOUN
gs-4060	1103	29	-	-	PUNCT
gs-4060	1103	30	high	high	ADJ
gs-4060	1103	31	solid	solid	ADJ
gs-4060	1103	32	tumors	tumor	NOUN
gs-4060	1103	33	.	.	PUNCT
gs-4060	1104	1	clin	clin	PROPN
gs-4060	1104	2	cancer	cancer	NOUN
gs-4060	1104	3	res	re	NOUN
gs-4060	1104	4	.	.	PUNCT
gs-4060	1104	5	2019;25(13):37538	2019;25(13):37538	NUM
gs-4060	1104	6	.	.	PUNCT
gs-4060	1105	1	92.yap	92.yap	PROPN
gs-4060	1105	2	ta	ta	PROPN
gs-4060	1105	3	,	,	PUNCT
gs-4060	1105	4	gerlinger	gerlinger	NOUN
gs-4060	1105	5	m	m	PROPN
gs-4060	1105	6	,	,	PUNCT
gs-4060	1105	7	futreal	futreal	ADJ
gs-4060	1105	8	pa	pa	PROPN
gs-4060	1105	9	,	,	PUNCT
gs-4060	1105	10	pusztai	pusztai	PROPN
gs-4060	1105	11	l	l	PROPN
gs-4060	1105	12	,	,	PUNCT
gs-4060	1105	13	swanton	swanton	PROPN
gs-4060	1105	14	c.	c.	PROPN
gs-4060	1105	15	intratumor	intratumor	PROPN
gs-4060	1105	16	heterogeneity	heterogeneity	PROPN
gs-4060	1105	17	:	:	PUNCT
gs-4060	1105	18	seeing	see	VERB
gs-4060	1105	19	the	the	DET
gs-4060	1105	20	wood	wood	NOUN
gs-4060	1105	21	for	for	ADP
gs-4060	1105	22	the	the	DET
gs-4060	1105	23	trees	tree	NOUN
gs-4060	1105	24	.	.	PUNCT
gs-4060	1106	1	sci	sci	PROPN
gs-4060	1106	2	transl	transl	PROPN
gs-4060	1106	3	med	med	PROPN
gs-4060	1106	4	.	.	PUNCT
gs-4060	1107	1	2012;4(127):127ps10	2012;4(127):127ps10	NUM
gs-4060	1107	2	.	.	PUNCT
gs-4060	1108	1	93.mcgranahan	93.mcgranahan	NUM
gs-4060	1108	2	n	n	CCONJ
gs-4060	1108	3	,	,	PUNCT
gs-4060	1108	4	swanton	swanton	PROPN
gs-4060	1108	5	c.	c.	PROPN
gs-4060	1108	6	clonal	clonal	PROPN
gs-4060	1108	7	heterogeneity	heterogeneity	PROPN
gs-4060	1108	8	and	and	CCONJ
gs-4060	1108	9	tumor	tumor	NOUN
gs-4060	1108	10	evolution	evolution	NOUN
gs-4060	1108	11	:	:	PUNCT
gs-4060	1108	12	past	past	ADJ
gs-4060	1108	13	,	,	PUNCT
gs-4060	1108	14	present	present	ADJ
gs-4060	1108	15	,	,	PUNCT
gs-4060	1108	16	and	and	CCONJ
gs-4060	1108	17	the	the	DET
gs-4060	1108	18	future	future	NOUN
gs-4060	1108	19	.	.	PUNCT
gs-4060	1109	1	cell	cell	NOUN
gs-4060	1109	2	.	.	PUNCT
gs-4060	1110	1	2017;168(4):613	2017;168(4):613	NUM
gs-4060	1110	2	-	-	SYM
gs-4060	1110	3	28	28	NUM
gs-4060	1110	4	.	.	PUNCT
gs-4060	1111	1	94.baylin	94.baylin	NUM
gs-4060	1111	2	sb	sb	PROPN
gs-4060	1111	3	,	,	PUNCT
gs-4060	1111	4	jones	jones	PROPN
gs-4060	1111	5	pa	pa	PROPN
gs-4060	1111	6	.	.	PROPN
gs-4060	1111	7	epigenetic	epigenetic	ADJ
gs-4060	1111	8	determinants	determinant	NOUN
gs-4060	1111	9	of	of	ADP
gs-4060	1111	10	cancer	cancer	NOUN
gs-4060	1111	11	.	.	PUNCT
gs-4060	1112	1	cold	cold	ADJ
gs-4060	1112	2	spring	spring	NOUN
gs-4060	1112	3	harb	harb	PROPN
gs-4060	1112	4	perspect	perspect	VERB
gs-4060	1112	5	biol	biol	PROPN
gs-4060	1112	6	.	.	PUNCT
gs-4060	1113	1	2016;8(9):a019505	2016;8(9):a019505	NUM
gs-4060	1113	2	.	.	PUNCT
gs-4060	1113	3	95.jones	95.jones	PROPN
gs-4060	1114	1	pa	pa	PROPN
gs-4060	1114	2	,	,	PUNCT
gs-4060	1114	3	issa	issa	PROPN
gs-4060	1114	4	jp	jp	PROPN
gs-4060	1114	5	,	,	PUNCT
gs-4060	1114	6	baylin	baylin	PROPN
gs-4060	1114	7	s.	s.	PROPN
gs-4060	1114	8	targeting	target	VERB
gs-4060	1114	9	the	the	DET
gs-4060	1114	10	cancer	cancer	NOUN
gs-4060	1114	11	epigenome	epigenome	NOUN
gs-4060	1114	12	for	for	ADP
gs-4060	1114	13	therapy	therapy	NOUN
gs-4060	1114	14	.	.	PUNCT
gs-4060	1115	1	nat	nat	PROPN
gs-4060	1115	2	rev	rev	PROPN
gs-4060	1115	3	genet	genet	PROPN
gs-4060	1115	4	.	.	PUNCT
gs-4060	1116	1	2016;17(10):630	2016;17(10):630	NUM
gs-4060	1116	2	-	-	PUNCT
gs-4060	1116	3	41	41	NUM
gs-4060	1116	4	.	.	PUNCT
gs-4060	1117	1	96.stein	96.stein	NUM
gs-4060	1118	1	em	em	PRON
gs-4060	1118	2	,	,	PUNCT
gs-4060	1118	3	dinardo	dinardo	PROPN
gs-4060	1118	4	cd	cd	PROPN
gs-4060	1118	5	,	,	PUNCT
gs-4060	1118	6	pollyea	pollyea	PROPN
gs-4060	1118	7	da	da	PROPN
gs-4060	1118	8	,	,	PUNCT
gs-4060	1118	9	fathi	fathi	PROPN
gs-4060	1118	10	at	at	ADP
gs-4060	1118	11	,	,	PUNCT
gs-4060	1118	12	roboz	roboz	PROPN
gs-4060	1118	13	gj	gj	PROPN
gs-4060	1118	14	,	,	PUNCT
gs-4060	1118	15	altman	altman	PROPN
gs-4060	1118	16	jk	jk	PROPN
gs-4060	1118	17	,	,	PUNCT
gs-4060	1118	18	et	et	PROPN
gs-4060	1118	19	al	al	PROPN
gs-4060	1118	20	.	.	PROPN
gs-4060	1118	21	enasidenib	enasidenib	NOUN
gs-4060	1118	22	in	in	ADP
gs-4060	1118	23	mutant	mutant	ADJ
gs-4060	1118	24	idh2	idh2	PROPN
gs-4060	1118	25	relapsed	relapse	VERB
gs-4060	1118	26	or	or	CCONJ
gs-4060	1118	27	refractory	refractory	NOUN
gs-4060	1118	28	acute	acute	NOUN
gs-4060	1118	29	myeloid	myeloid	NOUN
gs-4060	1118	30	leukemia	leukemia	NOUN
gs-4060	1118	31	.	.	PUNCT
gs-4060	1119	1	blood	blood	NOUN
gs-4060	1119	2	.	.	PUNCT
gs-4060	1120	1	2017;130(6):722	2017;130(6):722	NUM
gs-4060	1120	2	-	-	SYM
gs-4060	1120	3	31	31	NUM
gs-4060	1120	4	.	.	PUNCT
gs-4060	1121	1	97.stahl	97.stahl	NUM
gs-4060	1122	1	m	m	X
gs-4060	1122	2	,	,	PUNCT
gs-4060	1122	3	kohrman	kohrman	PROPN
gs-4060	1122	4	n	n	SYM
gs-4060	1122	5	,	,	PUNCT
gs-4060	1122	6	gore	gore	PROPN
gs-4060	1122	7	sd	sd	NOUN
gs-4060	1122	8	,	,	PUNCT
gs-4060	1122	9	kim	kim	PROPN
gs-4060	1122	10	tk	tk	PROPN
gs-4060	1122	11	,	,	PUNCT
gs-4060	1122	12	zeidan	zeidan	PROPN
gs-4060	1122	13	am	be	AUX
gs-4060	1122	14	,	,	PUNCT
gs-4060	1122	15	prebet	prebet	ADJ
gs-4060	1122	16	t.	t.	NOUN
gs-4060	1122	17	epigenetics	epigenetic	NOUN
gs-4060	1122	18	in	in	ADP
gs-4060	1122	19	cancer	cancer	NOUN
gs-4060	1122	20	:	:	PUNCT
gs-4060	1122	21	a	a	DET
gs-4060	1122	22	hematological	hematological	ADJ
gs-4060	1122	23	perspective	perspective	NOUN
gs-4060	1122	24	.	.	PUNCT
gs-4060	1123	1	plos	plos	PROPN
gs-4060	1123	2	genet	genet	PROPN
gs-4060	1123	3	.	.	PUNCT
gs-4060	1124	1	2016;12(10):e1006193	2016;12(10):e1006193	NOUN
gs-4060	1124	2	.	.	PUNCT
gs-4060	1125	1	98.lewis	98.lewis	NUM
gs-4060	1125	2	pw	pw	X
gs-4060	1125	3	,	,	PUNCT
gs-4060	1125	4	müller	müller	PROPN
gs-4060	1125	5	mm	mm	PROPN
gs-4060	1125	6	,	,	PUNCT
gs-4060	1125	7	koletsky	koletsky	PROPN
gs-4060	1125	8	ms	ms	PROPN
gs-4060	1125	9	,	,	PUNCT
gs-4060	1125	10	cordero	cordero	PROPN
gs-4060	1125	11	f	f	PROPN
gs-4060	1125	12	,	,	PUNCT
gs-4060	1125	13	lin	lin	PROPN
gs-4060	1125	14	s	s	PROPN
gs-4060	1125	15	,	,	PUNCT
gs-4060	1125	16	banaszynski	banaszynski	PROPN
gs-4060	1125	17	la	la	PROPN
gs-4060	1125	18	,	,	PUNCT
gs-4060	1125	19	et	et	PROPN
gs-4060	1125	20	al	al	PROPN
gs-4060	1125	21	.	.	PROPN
gs-4060	1125	22	inhibition	inhibition	NOUN
gs-4060	1125	23	of	of	ADP
gs-4060	1125	24	prc2	prc2	NOUN
gs-4060	1125	25	activity	activity	NOUN
gs-4060	1125	26	by	by	ADP
gs-4060	1125	27	a	a	DET
gs-4060	1125	28	gain	gain	NOUN
gs-4060	1125	29	-	-	PUNCT
gs-4060	1125	30	of	of	ADP
gs-4060	1125	31	-	-	PUNCT
gs-4060	1125	32	function	function	NOUN
gs-4060	1125	33	h3	h3	NOUN
gs-4060	1125	34	mutation	mutation	NOUN
gs-4060	1125	35	found	find	VERB
gs-4060	1125	36	in	in	ADP
gs-4060	1125	37	pediatric	pediatric	ADJ
gs-4060	1125	38	glioblastoma	glioblastoma	NOUN
gs-4060	1125	39	.	.	PUNCT
gs-4060	1126	1	science	science	NOUN
gs-4060	1126	2	.	.	PUNCT
gs-4060	1127	1	2013;340(6134):857	2013;340(6134):857	NUM
gs-4060	1127	2	-	-	SYM
gs-4060	1127	3	61	61	NUM
gs-4060	1127	4	.	.	PUNCT
gs-4060	1128	1	99.ståhl	99.ståhl	X
gs-4060	1128	2	pl	pl	X
gs-4060	1128	3	,	,	PUNCT
gs-4060	1128	4	salmén	salmén	ADJ
gs-4060	1128	5	f	f	NOUN
gs-4060	1128	6	,	,	PUNCT
gs-4060	1128	7	vickovic	vickovic	PROPN
gs-4060	1128	8	s	s	PROPN
gs-4060	1128	9	,	,	PUNCT
gs-4060	1128	10	lundmark	lundmark	NOUN
gs-4060	1128	11	a	a	NOUN
gs-4060	1128	12	,	,	PUNCT
gs-4060	1128	13	navarro	navarro	PROPN
gs-4060	1128	14	jf	jf	PROPN
gs-4060	1128	15	,	,	PUNCT
gs-4060	1128	16	magnusson	magnusson	PROPN
gs-4060	1128	17	j	j	PROPN
gs-4060	1128	18	,	,	PUNCT
gs-4060	1128	19	et	et	PROPN
gs-4060	1128	20	al	al	PROPN
gs-4060	1128	21	.	.	PUNCT
gs-4060	1128	22	visualization	visualization	NOUN
gs-4060	1128	23	and	and	CCONJ
gs-4060	1128	24	analysis	analysis	NOUN
gs-4060	1128	25	of	of	ADP
gs-4060	1128	26	gene	gene	NOUN
gs-4060	1128	27	expression	expression	NOUN
gs-4060	1128	28	in	in	ADP
gs-4060	1128	29	tissue	tissue	NOUN
gs-4060	1128	30	sections	section	NOUN
gs-4060	1128	31	by	by	ADP
gs-4060	1128	32	spatial	spatial	ADJ
gs-4060	1128	33	transcriptomics	transcriptomic	NOUN
gs-4060	1128	34	.	.	PUNCT
gs-4060	1129	1	science	science	NOUN
gs-4060	1129	2	.	.	PUNCT
gs-4060	1130	1	2016;353(6294):78	2016;353(6294):78	PROPN
gs-4060	1130	2	-	-	PUNCT
gs-4060	1130	3	82	82	NUM
gs-4060	1130	4	.	.	NOUN
gs-4060	1130	5	100	100	NUM
gs-4060	1130	6	.	.	PUNCT
gs-4060	1131	1	jackson	jackson	PROPN
gs-4060	1131	2	hw	hw	PROPN
gs-4060	1131	3	,	,	PUNCT
gs-4060	1131	4	fischer	fischer	PROPN
gs-4060	1131	5	jr	jr	PROPN
gs-4060	1131	6	,	,	PUNCT
gs-4060	1131	7	zanotelli	zanotelli	PROPN
gs-4060	1131	8	vrt	vrt	PROPN
gs-4060	1131	9	,	,	PUNCT
gs-4060	1131	10	ali	ali	PROPN
gs-4060	1131	11	hr	hr	PROPN
gs-4060	1131	12	,	,	PUNCT
gs-4060	1131	13	mechera	mechera	NOUN
gs-4060	1131	14	r	r	NOUN
gs-4060	1131	15	,	,	PUNCT
gs-4060	1131	16	soysal	soysal	NOUN
gs-4060	1131	17	sd	sd	PROPN
gs-4060	1131	18	,	,	PUNCT
gs-4060	1131	19	et	et	PROPN
gs-4060	1131	20	al	al	PROPN
gs-4060	1131	21	.	.	PUNCT
gs-4060	1132	1	the	the	DET
gs-4060	1132	2	singlecell	singlecell	NOUN
gs-4060	1132	3	pathology	pathology	NOUN
gs-4060	1132	4	landscape	landscape	NOUN
gs-4060	1132	5	of	of	ADP
gs-4060	1132	6	breast	breast	NOUN
gs-4060	1132	7	cancer	cancer	NOUN
gs-4060	1132	8	.	.	PUNCT
gs-4060	1133	1	nature	nature	NOUN
gs-4060	1133	2	.	.	PUNCT
gs-4060	1134	1	2020;578(7796):615	2020;578(7796):615	NUM
gs-4060	1134	2	-	-	SYM
gs-4060	1134	3	20	20	NUM
gs-4060	1134	4	.	.	PUNCT
gs-4060	1135	1	101	101	NUM
gs-4060	1135	2	.	.	PUNCT
gs-4060	1136	1	wu	wu	PROPN
gs-4060	1136	2	td	td	PROPN
gs-4060	1136	3	,	,	PUNCT
gs-4060	1136	4	madireddi	madireddi	NOUN
gs-4060	1136	5	s	s	PROPN
gs-4060	1136	6	,	,	PUNCT
gs-4060	1136	7	de	de	PROPN
gs-4060	1136	8	almeida	almeida	PROPN
gs-4060	1136	9	pe	pe	PROPN
gs-4060	1136	10	,	,	PUNCT
gs-4060	1136	11	banchereau	banchereau	PROPN
gs-4060	1136	12	r	r	PROPN
gs-4060	1136	13	,	,	PUNCT
gs-4060	1136	14	chen	chen	PROPN
gs-4060	1136	15	yj	yj	PROPN
gs-4060	1136	16	,	,	PUNCT
gs-4060	1136	17	chitre	chitre	NOUN
gs-4060	1136	18	as	as	ADP
gs-4060	1136	19	,	,	PUNCT
gs-4060	1136	20	et	et	PROPN
gs-4060	1136	21	al	al	PROPN
gs-4060	1136	22	.	.	PROPN
gs-4060	1136	23	peripheral	peripheral	PROPN
gs-4060	1136	24	t	t	PROPN
gs-4060	1136	25	cell	cell	NOUN
gs-4060	1136	26	expansion	expansion	NOUN
gs-4060	1136	27	predicts	predict	VERB
gs-4060	1136	28	tumour	tumour	NOUN
gs-4060	1136	29	infiltration	infiltration	NOUN
gs-4060	1136	30	and	and	CCONJ
gs-4060	1136	31	clinical	clinical	ADJ
gs-4060	1136	32	response	response	NOUN
gs-4060	1136	33	.	.	PUNCT
gs-4060	1137	1	nature	nature	NOUN
gs-4060	1137	2	.	.	PUNCT
gs-4060	1138	1	2020;579(7798):2748	2020;579(7798):2748	X
gs-4060	1138	2	.	.	X
gs-4060	1139	1	102	102	NUM
gs-4060	1139	2	.	.	PUNCT
gs-4060	1140	1	palmer	palmer	PROPN
gs-4060	1140	2	ac	ac	PROPN
gs-4060	1140	3	,	,	PUNCT
gs-4060	1140	4	sorger	sorger	PROPN
gs-4060	1140	5	pk	pk	NOUN
gs-4060	1140	6	.	.	PROPN
gs-4060	1140	7	combination	combination	NOUN
gs-4060	1140	8	cancer	cancer	NOUN
gs-4060	1140	9	therapy	therapy	NOUN
gs-4060	1140	10	can	can	AUX
gs-4060	1140	11	confer	confer	VERB
gs-4060	1140	12	benefit	benefit	NOUN
gs-4060	1140	13	via	via	ADP
gs-4060	1140	14	patient	patient	NOUN
gs-4060	1140	15	-	-	PUNCT
gs-4060	1140	16	topatient	topatient	NOUN
gs-4060	1140	17	variability	variability	NOUN
gs-4060	1140	18	without	without	ADP
gs-4060	1140	19	drug	drug	NOUN
gs-4060	1140	20	additivity	additivity	NOUN
gs-4060	1140	21	or	or	CCONJ
gs-4060	1140	22	synergy	synergy	NOUN
gs-4060	1140	23	.	.	PUNCT
gs-4060	1141	1	cell	cell	NOUN
gs-4060	1141	2	.	.	PUNCT
gs-4060	1142	1	2017;171(7):1678	2017;171(7):1678	NUM
gs-4060	1142	2	-	-	SYM
gs-4060	1142	3	1691.e13	1691.e13	NUM
gs-4060	1142	4	.	.	PUNCT
gs-4060	1143	1	103	103	NUM
gs-4060	1143	2	.	.	PUNCT
gs-4060	1144	1	woodcock	woodcock	PROPN
gs-4060	1144	2	j	j	PROPN
gs-4060	1144	3	,	,	PUNCT
gs-4060	1144	4	lavange	lavange	PROPN
gs-4060	1144	5	lm	lm	INTJ
gs-4060	1144	6	.	.	PUNCT
gs-4060	1145	1	master	master	PROPN
gs-4060	1145	2	protocols	protocol	NOUN
gs-4060	1145	3	to	to	PART
gs-4060	1145	4	study	study	VERB
gs-4060	1145	5	multiple	multiple	ADJ
gs-4060	1145	6	therapies	therapy	NOUN
gs-4060	1145	7	,	,	PUNCT
gs-4060	1145	8	multiple	multiple	ADJ
gs-4060	1145	9	diseases	disease	NOUN
gs-4060	1145	10	,	,	PUNCT
gs-4060	1145	11	or	or	CCONJ
gs-4060	1145	12	both	both	PRON
gs-4060	1145	13	.	.	PUNCT
gs-4060	1146	1	n	n	PROPN
gs-4060	1146	2	engl	engl	PROPN
gs-4060	1146	3	j	j	PROPN
gs-4060	1146	4	med	med	PROPN
gs-4060	1146	5	.	.	PUNCT
gs-4060	1147	1	2017;377(1):62	2017;377(1):62	NUM
gs-4060	1147	2	-	-	SYM
gs-4060	1147	3	70	70	NUM
gs-4060	1147	4	.	.	PUNCT