id	sid	tid	token	lemma	pos
gs-4062	1	1	georgian	georgian	PROPN
gs-4062	1	2	scientists/	scientists/	NUM
gs-4062	1	3	.	.	PUNCT
gs-4062	2	1	7	7	NUM
gs-4062	2	2	n	n	PRON
gs-4062	2	3	3	3	NUM
gs-4062	2	4	,	,	PUNCT
gs-4062	2	5	2025	2025	NUM
gs-4062	2	6	522	522	NUM
gs-4062	2	7	georgian	georgian	ADJ
gs-4062	2	8	scientists	scientist	NOUN
gs-4062	2	9	vol	vol	NOUN
gs-4062	2	10	.	.	PUNCT
gs-4062	2	11	7	7	NUM
gs-4062	2	12	issue	issue	NOUN
gs-4062	2	13	3	3	NUM
gs-4062	2	14	,	,	PUNCT
gs-4062	2	15	2025	2025	NUM
gs-4062	2	16	https://doi.org/10.52340/gs.2025.07.03.30	https://doi.org/10.52340/gs.2025.07.03.30	VERB
gs-4062	2	17	the	the	DET
gs-4062	2	18	manifestation	manifestation	NOUN
gs-4062	2	19	of	of	ADP
gs-4062	2	20	scientific	scientific	ADJ
gs-4062	2	21	discussion	discussion	NOUN
gs-4062	2	22	on	on	ADP
gs-4062	2	23	new	new	ADJ
gs-4062	2	24	antiretroviral	antiretroviral	ADJ
gs-4062	2	25	medicines	medicine	NOUN
gs-4062	2	26	:	:	PUNCT
gs-4062	2	27	a	a	DET
gs-4062	2	28	comprehensive	comprehensive	ADJ
gs-4062	2	29	analysis	analysis	NOUN
gs-4062	2	30	of	of	ADP
gs-4062	2	31	classification	classification	NOUN
gs-4062	2	32	,	,	PUNCT
gs-4062	2	33	clinical	clinical	ADJ
gs-4062	2	34	use	use	NOUN
gs-4062	2	35	,	,	PUNCT
gs-4062	2	36	features	feature	NOUN
gs-4062	2	37	,	,	PUNCT
gs-4062	2	38	mechanisms	mechanism	NOUN
gs-4062	2	39	,	,	PUNCT
gs-4062	2	40	pharmacology	pharmacology	NOUN
gs-4062	2	41	and	and	CCONJ
gs-4062	2	42	toxicities	toxicity	NOUN
gs-4062	2	43	in	in	ADP
gs-4062	2	44	general	general	ADJ
gs-4062	2	45	nodar	nodar	PROPN
gs-4062	2	46	sulashvili1	sulashvili1	PROPN
gs-4062	2	47	,	,	PUNCT
gs-4062	2	48	udgam	udgam	PROPN
gs-4062	2	49	yaduvanshi2	yaduvanshi2	NOUN
gs-4062	2	50	,	,	PUNCT
gs-4062	2	51	nirjhar	nirjhar	VERB
gs-4062	2	52	yaduvanshi3	yaduvanshi3	PROPN
gs-4062	2	53	,	,	PUNCT
gs-4062	2	54	mohini	mohini	PROPN
gs-4062	2	55	yadav4	yadav4	PROPN
gs-4062	2	56	,	,	PUNCT
gs-4062	2	57	elene	elene	NOUN
gs-4062	2	58	abzianidze5	abzianidze5	NOUN
gs-4062	2	59	,	,	PUNCT
gs-4062	2	60	naira	naira	PROPN
gs-4062	2	61	chichoyan6	chichoyan6	NOUN
gs-4062	2	62	,	,	PUNCT
gs-4062	2	63	luiza	luiza	PROPN
gs-4062	2	64	gabunia7	gabunia7	PROPN
gs-4062	2	65	,	,	PUNCT
gs-4062	2	66	nana	nana	PROPN
gs-4062	2	67	gorgaslidze8	gorgaslidze8	PROPN
gs-4062	2	68	,	,	PUNCT
gs-4062	2	69	nato	nato	PROPN
gs-4062	2	70	alavidze9	alavidze9	PROPN
gs-4062	2	71	,	,	PUNCT
gs-4062	2	72	nino	nino	PROPN
gs-4062	2	73	abuladze10	abuladze10	PROPN
gs-4062	2	74	,	,	PUNCT
gs-4062	2	75	ketevani	ketevani	PROPN
gs-4062	2	76	gabunia11	gabunia11	PROPN
gs-4062	2	77	,	,	PUNCT
gs-4062	2	78	natia	natia	PROPN
gs-4062	2	79	kvizhinadze12	kvizhinadze12	PROPN
gs-4062	2	80	,	,	PUNCT
gs-4062	2	81	igor	igor	PROPN
gs-4062	2	82	seniuk13	seniuk13	PROPN
gs-4062	2	83	,	,	PUNCT
gs-4062	2	84	marika	marika	PROPN
gs-4062	2	85	sulashvili14	sulashvili14	PROPN
gs-4062	2	86	,	,	PUNCT
gs-4062	2	87	tamar	tamar	PROPN
gs-4062	2	88	okropiridze15	okropiridze15	PROPN
gs-4062	2	89	,	,	PUNCT
gs-4062	2	90	lela	lela	PROPN
gs-4062	2	91	grigolia16	grigolia16	PROPN
gs-4062	2	92	,	,	PUNCT
gs-4062	2	93	kakhaber	kakhaber	PROPN
gs-4062	2	94	robakidze17	robakidze17	PROPN
gs-4062	2	95	,	,	PUNCT
gs-4062	2	96	marina	marina	PROPN
gs-4062	2	97	giorgobiani18	giorgobiani18	PROPN
gs-4062	2	98	,	,	PUNCT
gs-4062	2	99	irine	irine	NOUN
gs-4062	2	100	zarnadze19	zarnadze19	NOUN
gs-4062	2	101	,	,	PUNCT
gs-4062	2	102	shalva	shalva	PROPN
gs-4062	2	103	(	(	PUNCT
gs-4062	2	104	davit	davit	NOUN
gs-4062	2	105	)	)	PUNCT
gs-4062	2	106	zarnadze20	zarnadze20	PROPN
gs-4062	2	107	1	1	NUM
gs-4062	2	108	.	.	X
gs-4062	2	109	md	md	PROPN
gs-4062	2	110	,	,	PUNCT
gs-4062	2	111	phd	phd	NOUN
gs-4062	2	112	,	,	PUNCT
gs-4062	2	113	doctor	doctor	NOUN
gs-4062	2	114	of	of	ADP
gs-4062	2	115	pharmaceutical	pharmaceutical	ADJ
gs-4062	2	116	and	and	CCONJ
gs-4062	2	117	pharmacological	pharmacological	ADJ
gs-4062	2	118	sciences	science	NOUN
gs-4062	2	119	in	in	ADP
gs-4062	2	120	medicine	medicine	NOUN
gs-4062	2	121	,	,	PUNCT
gs-4062	2	122	invited	invite	VERB
gs-4062	2	123	lecturer	lecturer	NOUN
gs-4062	2	124	(	(	PUNCT
gs-4062	2	125	invited	invite	VERB
gs-4062	2	126	professor	professor	NOUN
gs-4062	2	127	)	)	PUNCT
gs-4062	2	128	of	of	ADP
gs-4062	2	129	scientific	scientific	ADJ
gs-4062	2	130	research	research	NOUN
gs-4062	2	131	-	-	PUNCT
gs-4062	2	132	skills	skill	NOUN
gs-4062	2	133	center	center	NOUN
gs-4062	2	134	at	at	ADP
gs-4062	2	135	tbilisi	tbilisi	PROPN
gs-4062	2	136	state	state	PROPN
gs-4062	2	137	medical	medical	PROPN
gs-4062	2	138	university	university	PROPN
gs-4062	2	139	;	;	PUNCT
gs-4062	2	140	professor	professor	NOUN
gs-4062	2	141	of	of	ADP
gs-4062	2	142	medical	medical	ADJ
gs-4062	2	143	and	and	CCONJ
gs-4062	2	144	clinical	clinical	ADJ
gs-4062	2	145	pharmacology	pharmacology	NOUN
gs-4062	2	146	of	of	ADP
gs-4062	2	147	international	international	ADJ
gs-4062	2	148	school	school	NOUN
gs-4062	2	149	of	of	ADP
gs-4062	2	150	medicine	medicine	NOUN
gs-4062	2	151	at	at	ADP
gs-4062	2	152	alte	alte	PROPN
gs-4062	2	153	university	university	PROPN
gs-4062	2	154	;	;	PUNCT
gs-4062	2	155	professor	professor	NOUN
gs-4062	2	156	of	of	ADP
gs-4062	2	157	pharmacology	pharmacology	NOUN
gs-4062	2	158	of	of	ADP
gs-4062	2	159	faculty	faculty	NOUN
gs-4062	2	160	of	of	ADP
gs-4062	2	161	medicine	medicine	NOUN
gs-4062	2	162	at	at	ADP
gs-4062	2	163	georgian	georgian	PROPN
gs-4062	2	164	national	national	PROPN
gs-4062	2	165	university	university	PROPN
gs-4062	2	166	seu	seu	PROPN
gs-4062	2	167	;	;	PUNCT
gs-4062	2	168	tbilisi	tbilisi	PROPN
gs-4062	2	169	,	,	PUNCT
gs-4062	2	170	georgia	georgia	PROPN
gs-4062	2	171	;	;	PUNCT
gs-4062	2	172	orcid	orcid	PROPN
gs-4062	2	173	https://orcid.org/0000-0002-9005-8577	https://orcid.org/0000-0002-9005-8577	PROPN
gs-4062	2	174	;	;	PUNCT
gs-4062	2	175	email	email	NOUN
gs-4062	2	176	:	:	PUNCT
gs-4062	2	177	n.sulashvili@ug.edu.ge	n.sulashvili@ug.edu.ge	PROPN
gs-4062	2	178	2	2	NUM
gs-4062	2	179	.	.	PUNCT
gs-4062	2	180	md	md	PROPN
gs-4062	2	181	student	student	NOUN
gs-4062	2	182	of	of	ADP
gs-4062	2	183	medical	medical	ADJ
gs-4062	2	184	doctor	doctor	NOUN
gs-4062	2	185	degree	degree	NOUN
gs-4062	2	186	program	program	NOUN
gs-4062	2	187	of	of	ADP
gs-4062	2	188	international	international	ADJ
gs-4062	2	189	school	school	NOUN
gs-4062	2	190	of	of	ADP
gs-4062	2	191	medicine	medicine	NOUN
gs-4062	2	192	at	at	ADP
gs-4062	2	193	alte	alte	PROPN
gs-4062	2	194	university	university	PROPN
gs-4062	2	195	;	;	PUNCT
gs-4062	2	196	tbilisi	tbilisi	PROPN
gs-4062	2	197	,	,	PUNCT
gs-4062	2	198	georgia	georgia	PROPN
gs-4062	2	199	;	;	PUNCT
gs-4062	2	200	3	3	X
gs-4062	2	201	.	.	X
gs-4062	2	202	md	md	PROPN
gs-4062	2	203	student	student	NOUN
gs-4062	2	204	of	of	ADP
gs-4062	2	205	medical	medical	ADJ
gs-4062	2	206	doctor	doctor	NOUN
gs-4062	2	207	degree	degree	NOUN
gs-4062	2	208	program	program	NOUN
gs-4062	2	209	of	of	ADP
gs-4062	2	210	international	international	ADJ
gs-4062	2	211	school	school	NOUN
gs-4062	2	212	of	of	ADP
gs-4062	2	213	medicine	medicine	NOUN
gs-4062	2	214	at	at	ADP
gs-4062	2	215	alte	alte	PROPN
gs-4062	2	216	university	university	PROPN
gs-4062	2	217	;	;	PUNCT
gs-4062	2	218	tbilisi	tbilisi	PROPN
gs-4062	2	219	,	,	PUNCT
gs-4062	2	220	georgia	georgia	PROPN
gs-4062	2	221	;	;	PUNCT
gs-4062	2	222	4	4	NUM
gs-4062	2	223	.	.	X
gs-4062	2	224	md	md	PROPN
gs-4062	2	225	student	student	NOUN
gs-4062	2	226	of	of	ADP
gs-4062	2	227	medical	medical	ADJ
gs-4062	2	228	doctor	doctor	NOUN
gs-4062	2	229	degree	degree	NOUN
gs-4062	2	230	program	program	NOUN
gs-4062	2	231	of	of	ADP
gs-4062	2	232	international	international	ADJ
gs-4062	2	233	school	school	NOUN
gs-4062	2	234	of	of	ADP
gs-4062	2	235	medicine	medicine	NOUN
gs-4062	2	236	at	at	ADP
gs-4062	2	237	alte	alte	PROPN
gs-4062	2	238	university	university	PROPN
gs-4062	2	239	;	;	PUNCT
gs-4062	2	240	tbilisi	tbilisi	PROPN
gs-4062	2	241	,	,	PUNCT
gs-4062	2	242	georgia	georgia	PROPN
gs-4062	2	243	;	;	PUNCT
gs-4062	2	244	5	5	NUM
gs-4062	2	245	.	.	X
gs-4062	2	246	phd	phd	NOUN
gs-4062	2	247	,	,	PUNCT
gs-4062	2	248	doctor	doctor	NOUN
gs-4062	2	249	of	of	ADP
gs-4062	2	250	biological	biological	ADJ
gs-4062	2	251	sciences	science	NOUN
gs-4062	2	252	,	,	PUNCT
gs-4062	2	253	academician	academician	NOUN
gs-4062	2	254	,	,	PUNCT
gs-4062	2	255	emeritus	emeritus	ADJ
gs-4062	2	256	professor	professor	NOUN
gs-4062	2	257	of	of	ADP
gs-4062	2	258	tbilisi	tbilisi	PROPN
gs-4062	2	259	state	state	PROPN
gs-4062	2	260	medical	medical	PROPN
gs-4062	2	261	university	university	PROPN
gs-4062	2	262	,	,	PUNCT
gs-4062	2	263	department	department	NOUN
gs-4062	2	264	of	of	ADP
gs-4062	2	265	molecular	molecular	ADJ
gs-4062	2	266	and	and	CCONJ
gs-4062	2	267	medical	medical	ADJ
gs-4062	2	268	genetics	genetic	NOUN
gs-4062	2	269	;	;	PUNCT
gs-4062	2	270	https://orcid.org/0000-0002-1140-7688	https://orcid.org/0000-0002-1140-7688	PROPN
gs-4062	2	271	;	;	PUNCT
gs-4062	2	272	tbilisi	tbilisi	PROPN
gs-4062	2	273	,	,	PUNCT
gs-4062	2	274	georgia	georgia	PROPN
gs-4062	2	275	.	.	PUNCT
gs-4062	3	1	6	6	NUM
gs-4062	3	2	.	.	X
gs-4062	3	3	md	md	PROPN
gs-4062	3	4	,	,	PUNCT
gs-4062	3	5	phd	phd	NOUN
gs-4062	3	6	,	,	PUNCT
gs-4062	3	7	doctor	doctor	NOUN
gs-4062	3	8	of	of	ADP
gs-4062	3	9	pharmaceutical	pharmaceutical	NOUN
gs-4062	3	10	sciences	science	NOUN
gs-4062	3	11	,	,	PUNCT
gs-4062	3	12	professor	professor	NOUN
gs-4062	3	13	of	of	ADP
gs-4062	3	14	yerevan	yerevan	PROPN
gs-4062	3	15	state	state	PROPN
gs-4062	3	16	medical	medical	PROPN
gs-4062	3	17	university	university	PROPN
gs-4062	3	18	after	after	ADP
gs-4062	3	19	mkhitar	mkhitar	NOUN
gs-4062	3	20	heratsi	heratsi	PROPN
gs-4062	3	21	,	,	PUNCT
gs-4062	3	22	head	head	NOUN
gs-4062	3	23	of	of	ADP
gs-4062	3	24	the	the	DET
gs-4062	3	25	department	department	NOUN
gs-4062	3	26	of	of	ADP
gs-4062	3	27	pharmacognosy	pharmacognosy	NOUN
gs-4062	3	28	,	,	PUNCT
gs-4062	3	29	yerevan	yerevan	PROPN
gs-4062	3	30	,	,	PUNCT
gs-4062	3	31	armenia	armenia	PROPN
gs-4062	3	32	.	.	PUNCT
gs-4062	4	1	https://orcid.org/0000-0003-3905-3372	https://orcid.org/0000-0003-3905-3372	PROPN
gs-4062	4	2	7	7	NUM
gs-4062	4	3	.	.	PUNCT
gs-4062	4	4	md	md	PROPN
gs-4062	4	5	,	,	PUNCT
gs-4062	4	6	phd	phd	NOUN
gs-4062	4	7	,	,	PUNCT
gs-4062	4	8	doctor	doctor	NOUN
gs-4062	4	9	of	of	ADP
gs-4062	4	10	medical	medical	ADJ
gs-4062	4	11	sciences	sciences	PROPN
gs-4062	4	12	,	,	PUNCT
gs-4062	4	13	professor	professor	NOUN
gs-4062	4	14	,	,	PUNCT
gs-4062	4	15	director	director	NOUN
gs-4062	4	16	of	of	ADP
gs-4062	4	17	the	the	DET
gs-4062	4	18	scientific	scientific	ADJ
gs-4062	4	19	research	research	NOUN
gs-4062	4	20	-	-	PUNCT
gs-4062	4	21	skills	skill	NOUN
gs-4062	4	22	center	center	NOUN
gs-4062	4	23	at	at	ADP
gs-4062	4	24	tbilisi	tbilisi	PROPN
gs-4062	4	25	state	state	PROPN
gs-4062	4	26	medical	medical	PROPN
gs-4062	4	27	university	university	PROPN
gs-4062	4	28	,	,	PUNCT
gs-4062	4	29	professor	professor	NOUN
gs-4062	4	30	,	,	PUNCT
gs-4062	4	31	head	head	NOUN
gs-4062	4	32	of	of	ADP
gs-4062	4	33	the	the	DET
gs-4062	4	34	department	department	PROPN
gs-4062	4	35	of	of	ADP
gs-4062	4	36	medical	medical	ADJ
gs-4062	4	37	and	and	CCONJ
gs-4062	4	38	clinical	clinical	ADJ
gs-4062	4	39	pharmacology	pharmacology	NOUN
gs-4062	4	40	at	at	ADP
gs-4062	4	41	tbilisi	tbilisi	PROPN
gs-4062	4	42	state	state	PROPN
gs-4062	4	43	medical	medical	PROPN
gs-4062	4	44	university	university	PROPN
gs-4062	4	45	,	,	PUNCT
gs-4062	4	46	clinical	clinical	ADJ
gs-4062	4	47	pharmacologist	pharmacologist	NOUN
gs-4062	4	48	of	of	ADP
gs-4062	4	49	the	the	DET
gs-4062	4	50	first	first	ADJ
gs-4062	4	51	university	university	NOUN
gs-4062	4	52	clinic	clinic	NOUN
gs-4062	4	53	of	of	ADP
gs-4062	4	54	tsmu	tsmu	PROPN
gs-4062	4	55	,	,	PUNCT
gs-4062	4	56	tbilisi	tbilisi	PROPN
gs-4062	4	57	,	,	PUNCT
gs-4062	4	58	georgia	georgia	PROPN
gs-4062	4	59	https://orcid.org/0000-0003-0856-2684	https://orcid.org/0000-0003-0856-2684	PROPN
gs-4062	4	60	8	8	NUM
gs-4062	4	61	.	.	PUNCT
gs-4062	5	1	md	md	PROPN
gs-4062	5	2	,	,	PUNCT
gs-4062	5	3	phd	phd	NOUN
gs-4062	5	4	,	,	PUNCT
gs-4062	5	5	doctor	doctor	NOUN
gs-4062	5	6	of	of	ADP
gs-4062	5	7	pharmaceutical	pharmaceutical	NOUN
gs-4062	5	8	sciences	science	NOUN
gs-4062	5	9	,	,	PUNCT
gs-4062	5	10	academician	academician	NOUN
gs-4062	5	11	,	,	PUNCT
gs-4062	5	12	professor	professor	NOUN
gs-4062	5	13	of	of	ADP
gs-4062	5	14	tbilisi	tbilisi	PROPN
gs-4062	5	15	state	state	PROPN
gs-4062	5	16	medical	medical	PROPN
gs-4062	5	17	university	university	PROPN
gs-4062	5	18	,	,	PUNCT
gs-4062	5	19	head	head	NOUN
gs-4062	5	20	of	of	ADP
gs-4062	5	21	the	the	DET
gs-4062	5	22	department	department	NOUN
gs-4062	5	23	of	of	ADP
gs-4062	5	24	social	social	ADJ
gs-4062	5	25	and	and	CCONJ
gs-4062	5	26	clinical	clinical	ADJ
gs-4062	5	27	pharmacy	pharmacy	NOUN
gs-4062	5	28	,	,	PUNCT
gs-4062	5	29	tbilisi	tbilisi	PROPN
gs-4062	5	30	,	,	PUNCT
gs-4062	5	31	georgia	georgia	PROPN
gs-4062	5	32	.	.	PUNCT
gs-4062	6	1	https://orcid.org/0000-0002-4563-5224	https://orcid.org/0000-0002-4563-5224	PROPN
gs-4062	6	2	9	9	NUM
gs-4062	6	3	.	.	X
gs-4062	7	1	md	md	PROPN
gs-4062	7	2	,	,	PUNCT
gs-4062	7	3	phd	phd	NOUN
gs-4062	7	4	,	,	PUNCT
gs-4062	7	5	doctor	doctor	NOUN
gs-4062	7	6	of	of	ADP
gs-4062	7	7	pharmaceutical	pharmaceutical	NOUN
gs-4062	7	8	sciences	science	NOUN
gs-4062	7	9	,	,	PUNCT
gs-4062	7	10	professor	professor	NOUN
gs-4062	7	11	of	of	ADP
gs-4062	7	12	akaki	akaki	PROPN
gs-4062	7	13	tsereteli	tsereteli	PROPN
gs-4062	7	14	state	state	PROPN
gs-4062	7	15	university	university	PROPN
gs-4062	7	16	,	,	PUNCT
gs-4062	7	17	faculty	faculty	NOUN
gs-4062	7	18	of	of	ADP
gs-4062	7	19	medicine	medicine	NOUN
gs-4062	7	20	,	,	PUNCT
gs-4062	7	21	department	department	NOUN
gs-4062	7	22	of	of	ADP
gs-4062	7	23	pharmacy	pharmacy	NOUN
gs-4062	7	24	,	,	PUNCT
gs-4062	7	25	kutaisi	kutaisi	PROPN
gs-4062	7	26	,	,	PUNCT
gs-4062	7	27	georgia	georgia	PROPN
gs-4062	7	28	.	.	PUNCT
gs-4062	8	1	professor	professor	PROPN
gs-4062	8	2	,	,	PUNCT
gs-4062	8	3	dean	dean	PROPN
gs-4062	8	4	faculty	faculty	NOUN
gs-4062	8	5	of	of	ADP
gs-4062	8	6	medicine	medicine	NOUN
gs-4062	8	7	at	at	ADP
gs-4062	8	8	east	east	PROPN
gs-4062	8	9	european	european	PROPN
gs-4062	8	10	university	university	PROPN
gs-4062	8	11	,	,	PUNCT
gs-4062	8	12	tbilisi	tbilisi	PROPN
gs-4062	8	13	,	,	PUNCT
gs-4062	8	14	georgia	georgia	PROPN
gs-4062	8	15	.	.	PUNCT
gs-4062	9	1	https://orcid.org/0000-0001-6695-5924	https://orcid.org/0000-0001-6695-5924	NOUN
gs-4062	9	2	10	10	NUM
gs-4062	9	3	.	.	PUNCT
gs-4062	10	1	md	md	PROPN
gs-4062	10	2	,	,	PUNCT
gs-4062	10	3	phd	phd	NOUN
gs-4062	10	4	,	,	PUNCT
gs-4062	10	5	doctor	doctor	NOUN
gs-4062	10	6	of	of	ADP
gs-4062	10	7	pharmaceutical	pharmaceutical	NOUN
gs-4062	10	8	sciences	science	NOUN
gs-4062	10	9	,	,	PUNCT
gs-4062	10	10	professor	professor	NOUN
gs-4062	10	11	of	of	ADP
gs-4062	10	12	akaki	akaki	PROPN
gs-4062	10	13	tsereteli	tsereteli	PROPN
gs-4062	10	14	state	state	PROPN
gs-4062	10	15	university	university	PROPN
gs-4062	10	16	,	,	PUNCT
gs-4062	10	17	faculty	faculty	NOUN
gs-4062	10	18	of	of	ADP
gs-4062	10	19	medicine	medicine	NOUN
gs-4062	10	20	,	,	PUNCT
gs-4062	10	21	department	department	NOUN
gs-4062	10	22	of	of	ADP
gs-4062	10	23	pharmacy	pharmacy	NOUN
gs-4062	10	24	,	,	PUNCT
gs-4062	10	25	kutaisi	kutaisi	PROPN
gs-4062	10	26	,	,	PUNCT
gs-4062	10	27	georgia	georgia	PROPN
gs-4062	10	28	.	.	PUNCT
gs-4062	11	1	https://orcid.org/0000-0003-2189-7470	https://orcid.org/0000-0003-2189-7470	PROPN
gs-4062	11	2	11	11	NUM
gs-4062	11	3	.	.	PUNCT
gs-4062	12	1	md	md	PROPN
gs-4062	12	2	,	,	PUNCT
gs-4062	12	3	phd	phd	NOUN
gs-4062	12	4	,	,	PUNCT
gs-4062	12	5	doctor	doctor	NOUN
gs-4062	12	6	of	of	ADP
gs-4062	12	7	pharmaceutical	pharmaceutical	NOUN
gs-4062	12	8	sciences	science	NOUN
gs-4062	12	9	,	,	PUNCT
gs-4062	12	10	professor	professor	NOUN
gs-4062	12	11	of	of	ADP
gs-4062	12	12	akaki	akaki	PROPN
gs-4062	12	13	tsereteli	tsereteli	PROPN
gs-4062	12	14	state	state	PROPN
gs-4062	12	15	university	university	PROPN
gs-4062	12	16	,	,	PUNCT
gs-4062	12	17	faculty	faculty	NOUN
gs-4062	12	18	of	of	ADP
gs-4062	12	19	medicine	medicine	NOUN
gs-4062	12	20	,	,	PUNCT
gs-4062	12	21	department	department	NOUN
gs-4062	12	22	of	of	ADP
gs-4062	12	23	pharmacy	pharmacy	NOUN
gs-4062	12	24	,	,	PUNCT
gs-4062	12	25	kutaisi	kutaisi	PROPN
gs-4062	12	26	,	,	PUNCT
gs-4062	12	27	georgia	georgia	PROPN
gs-4062	12	28	.	.	PUNCT
gs-4062	13	1	https://orcid.org/0000-0002-5857-6593	https://orcid.org/0000-0002-5857-6593	PROPN
gs-4062	13	2	;	;	PUNCT
gs-4062	13	3	12	12	NUM
gs-4062	13	4	.	.	PUNCT
gs-4062	14	1	md	md	PROPN
gs-4062	14	2	,	,	PUNCT
gs-4062	14	3	phd	phd	NOUN
gs-4062	14	4	,	,	PUNCT
gs-4062	14	5	doctor	doctor	NOUN
gs-4062	14	6	of	of	ADP
gs-4062	14	7	pharmaceutical	pharmaceutical	NOUN
gs-4062	14	8	sciences	science	NOUN
gs-4062	14	9	,	,	PUNCT
gs-4062	14	10	professor	professor	NOUN
gs-4062	14	11	of	of	ADP
gs-4062	14	12	tbilisi	tbilisi	PROPN
gs-4062	14	13	state	state	PROPN
gs-4062	14	14	medical	medical	PROPN
gs-4062	14	15	university	university	PROPN
gs-4062	14	16	,	,	PUNCT
gs-4062	14	17	department	department	NOUN
gs-4062	14	18	of	of	ADP
gs-4062	14	19	social	social	ADJ
gs-4062	14	20	and	and	CCONJ
gs-4062	14	21	clinical	clinical	ADJ
gs-4062	14	22	pharmacy	pharmacy	NOUN
gs-4062	14	23	;	;	PUNCT
gs-4062	14	24	tbilisi	tbilisi	PROPN
gs-4062	14	25	,	,	PUNCT
gs-4062	14	26	georgia	georgia	PROPN
gs-4062	14	27	.	.	PUNCT
gs-4062	15	1	13	13	NUM
gs-4062	15	2	.	.	X
gs-4062	15	3	phd	phd	NOUN
gs-4062	15	4	,	,	PUNCT
gs-4062	15	5	doctor	doctor	NOUN
gs-4062	15	6	of	of	ADP
gs-4062	15	7	pharmaceutical	pharmaceutical	NOUN
gs-4062	15	8	sciences	science	NOUN
gs-4062	15	9	,	,	PUNCT
gs-4062	15	10	dean	dean	NOUN
gs-4062	15	11	of	of	ADP
gs-4062	15	12	faculty	faculty	NOUN
gs-4062	15	13	of	of	ADP
gs-4062	15	14	pharmacy	pharmacy	NOUN
gs-4062	15	15	at	at	ADP
gs-4062	15	16	national	national	PROPN
gs-4062	15	17	university	university	PROPN
gs-4062	15	18	of	of	ADP
gs-4062	15	19	pharmacy	pharmacy	NOUN
gs-4062	15	20	of	of	ADP
gs-4062	15	21	ukraine	ukraine	NOUN
gs-4062	15	22	,	,	PUNCT
gs-4062	15	23	associate	associate	ADJ
gs-4062	15	24	professor	professor	NOUN
gs-4062	15	25	of	of	ADP
gs-4062	15	26	biological	biological	ADJ
gs-4062	15	27	chemistry	chemistry	NOUN
gs-4062	15	28	department	department	NOUN
gs-4062	15	29	at	at	ADP
gs-4062	15	30	national	national	PROPN
gs-4062	15	31	university	university	PROPN
gs-4062	15	32	of	of	ADP
gs-4062	15	33	pharmacy	pharmacy	NOUN
gs-4062	15	34	of	of	ADP
gs-4062	15	35	ukraine	ukraine	NOUN
gs-4062	15	36	,	,	PUNCT
gs-4062	15	37	https://orcid.org/0000-0003-3819-733	https://orcid.org/0000-0003-3819-733	PROPN
gs-4062	15	38	;	;	PUNCT
gs-4062	15	39	kharkiv	kharkiv	PROPN
gs-4062	15	40	,	,	PUNCT
gs-4062	15	41	ukraine	ukraine	NOUN
gs-4062	15	42	.	.	PUNCT
gs-4062	16	1	georgian	georgian	PROPN
gs-4062	16	2	scientists/	scientists/	NUM
gs-4062	16	3	.	.	PUNCT
gs-4062	17	1	7	7	NUM
gs-4062	17	2	n	n	PRON
gs-4062	17	3	3	3	NUM
gs-4062	17	4	,	,	PUNCT
gs-4062	17	5	2025	2025	NUM
gs-4062	17	6	523	523	NUM
gs-4062	17	7	14	14	NUM
gs-4062	17	8	.	.	PUNCT
gs-4062	18	1	md	md	PROPN
gs-4062	18	2	,	,	PUNCT
gs-4062	18	3	doctor	doctor	NOUN
gs-4062	18	4	of	of	ADP
gs-4062	18	5	family	family	NOUN
gs-4062	18	6	medicine	medicine	NOUN
gs-4062	18	7	,	,	PUNCT
gs-4062	18	8	invited	invite	VERB
gs-4062	18	9	lecturer	lecturer	NOUN
gs-4062	18	10	of	of	ADP
gs-4062	18	11	tbilisi	tbilisi	PROPN
gs-4062	18	12	state	state	PROPN
gs-4062	18	13	medical	medical	PROPN
gs-4062	18	14	university	university	PROPN
gs-4062	18	15	,	,	PUNCT
gs-4062	18	16	department	department	NOUN
gs-4062	18	17	of	of	ADP
gs-4062	18	18	molecular	molecular	ADJ
gs-4062	18	19	and	and	CCONJ
gs-4062	18	20	medical	medical	ADJ
gs-4062	18	21	genetics	genetic	NOUN
gs-4062	18	22	,	,	PUNCT
gs-4062	18	23	invited	invite	VERB
gs-4062	18	24	professor	professor	NOUN
gs-4062	18	25	of	of	ADP
gs-4062	18	26	biochemistry	biochemistry	NOUN
gs-4062	18	27	and	and	CCONJ
gs-4062	18	28	molecular	molecular	ADJ
gs-4062	18	29	and	and	CCONJ
gs-4062	18	30	medical	medical	ADJ
gs-4062	18	31	genetics	genetic	NOUN
gs-4062	18	32	at	at	ADP
gs-4062	18	33	the	the	DET
gs-4062	18	34	university	university	PROPN
gs-4062	18	35	of	of	ADP
gs-4062	18	36	georgia	georgia	PROPN
gs-4062	18	37	;	;	PUNCT
gs-4062	18	38	tbilisi	tbilisi	PROPN
gs-4062	18	39	,	,	PUNCT
gs-4062	18	40	georgia	georgia	PROPN
gs-4062	18	41	.	.	PUNCT
gs-4062	19	1	15	15	NUM
gs-4062	19	2	.	.	X
gs-4062	20	1	md	md	PROPN
gs-4062	20	2	,	,	PUNCT
gs-4062	20	3	phd	phd	PROPN
gs-4062	20	4	,	,	PUNCT
gs-4062	20	5	doctor	doctor	PROPN
gs-4062	20	6	medical	medical	PROPN
gs-4062	20	7	sciences	sciences	PROPN
gs-4062	20	8	,	,	PUNCT
gs-4062	20	9	professor	professor	NOUN
gs-4062	20	10	of	of	ADP
gs-4062	20	11	the	the	DET
gs-4062	20	12	division	division	NOUN
gs-4062	20	13	of	of	ADP
gs-4062	20	14	dentistry	dentistry	NOUN
gs-4062	20	15	of	of	ADP
gs-4062	20	16	international	international	ADJ
gs-4062	20	17	school	school	NOUN
gs-4062	20	18	of	of	ADP
gs-4062	20	19	medicine	medicine	NOUN
gs-4062	20	20	at	at	ADP
gs-4062	20	21	alte	alte	PROPN
gs-4062	20	22	university	university	PROPN
gs-4062	20	23	;	;	PUNCT
gs-4062	20	24	professor	professor	NOUN
gs-4062	20	25	of	of	ADP
gs-4062	20	26	teaching	teach	VERB
gs-4062	20	27	university	university	NOUN
gs-4062	20	28	geomedi	geomedi	NOUN
gs-4062	20	29	,	,	PUNCT
gs-4062	20	30	invited	invite	VERB
gs-4062	20	31	professor	professor	NOUN
gs-4062	20	32	of	of	ADP
gs-4062	20	33	dentistry	dentistry	PROPN
gs-4062	20	34	department	department	PROPN
gs-4062	20	35	of	of	ADP
gs-4062	20	36	the	the	DET
gs-4062	20	37	school	school	NOUN
gs-4062	20	38	of	of	ADP
gs-4062	20	39	health	health	NOUN
gs-4062	20	40	sciences	science	NOUN
gs-4062	20	41	at	at	ADP
gs-4062	20	42	the	the	DET
gs-4062	20	43	university	university	PROPN
gs-4062	20	44	of	of	ADP
gs-4062	20	45	georgia	georgia	PROPN
gs-4062	20	46	,	,	PUNCT
gs-4062	20	47	tbilisi	tbilisi	PROPN
gs-4062	20	48	,	,	PUNCT
gs-4062	20	49	georgia	georgia	PROPN
gs-4062	20	50	.	.	PUNCT
gs-4062	21	1	16	16	NUM
gs-4062	21	2	.	.	PUNCT
gs-4062	22	1	md	md	PROPN
gs-4062	22	2	,	,	PUNCT
gs-4062	22	3	phd	phd	NOUN
gs-4062	22	4	,	,	PUNCT
gs-4062	22	5	doctor	doctor	NOUN
gs-4062	22	6	of	of	ADP
gs-4062	22	7	medical	medical	ADJ
gs-4062	22	8	sciences	science	NOUN
gs-4062	22	9	,	,	PUNCT
gs-4062	22	10	professor	professor	NOUN
gs-4062	22	11	of	of	ADP
gs-4062	22	12	faculty	faculty	NOUN
gs-4062	22	13	of	of	ADP
gs-4062	22	14	medicine	medicine	NOUN
gs-4062	22	15	at	at	ADP
gs-4062	22	16	caucasus	caucasus	PROPN
gs-4062	22	17	international	international	PROPN
gs-4062	22	18	university	university	PROPN
gs-4062	22	19	;	;	PUNCT
gs-4062	22	20	tbilisi	tbilisi	PROPN
gs-4062	22	21	,	,	PUNCT
gs-4062	22	22	georgia	georgia	PROPN
gs-4062	22	23	;	;	PUNCT
gs-4062	22	24	17	17	NUM
gs-4062	22	25	.	.	X
gs-4062	23	1	md	md	PROPN
gs-4062	23	2	,	,	PUNCT
gs-4062	23	3	phd	phd	NOUN
gs-4062	23	4	,	,	PUNCT
gs-4062	23	5	doctor	doctor	NOUN
gs-4062	23	6	of	of	ADP
gs-4062	23	7	medical	medical	ADJ
gs-4062	23	8	sciences	science	NOUN
gs-4062	23	9	,	,	PUNCT
gs-4062	23	10	academician	academician	NOUN
gs-4062	23	11	,	,	PUNCT
gs-4062	23	12	professor	professor	NOUN
gs-4062	23	13	of	of	ADP
gs-4062	23	14	faculty	faculty	NOUN
gs-4062	23	15	of	of	ADP
gs-4062	23	16	medicine	medicine	NOUN
gs-4062	23	17	at	at	ADP
gs-4062	23	18	caucasus	caucasus	PROPN
gs-4062	23	19	international	international	PROPN
gs-4062	23	20	university	university	PROPN
gs-4062	23	21	;	;	PUNCT
gs-4062	23	22	doctor	doctor	NOUN
gs-4062	23	23	-	-	PUNCT
gs-4062	23	24	professor	professor	NOUN
gs-4062	23	25	of	of	ADP
gs-4062	23	26	national	national	PROPN
gs-4062	23	27	health	health	PROPN
gs-4062	23	28	center	center	NOUN
gs-4062	23	29	named	name	VERB
gs-4062	23	30	after	after	ADP
gs-4062	23	31	academician	academician	PROPN
gs-4062	23	32	o.	o.	PROPN
gs-4062	23	33	gudushauri	gudushauri	PROPN
gs-4062	23	34	;	;	PUNCT
gs-4062	23	35	tbilisi	tbilisi	PROPN
gs-4062	23	36	,	,	PUNCT
gs-4062	23	37	georgia	georgia	PROPN
gs-4062	23	38	;	;	PUNCT
gs-4062	23	39	18	18	NUM
gs-4062	23	40	.	.	X
gs-4062	23	41	md	md	PROPN
gs-4062	23	42	,	,	PUNCT
gs-4062	23	43	phd	phd	NOUN
gs-4062	23	44	,	,	PUNCT
gs-4062	23	45	doctor	doctor	NOUN
gs-4062	23	46	of	of	ADP
gs-4062	23	47	medical	medical	ADJ
gs-4062	23	48	sciences	science	NOUN
gs-4062	23	49	,	,	PUNCT
gs-4062	23	50	academician	academician	NOUN
gs-4062	23	51	,	,	PUNCT
gs-4062	23	52	professor	professor	NOUN
gs-4062	23	53	of	of	ADP
gs-4062	23	54	tbilisi	tbilisi	PROPN
gs-4062	23	55	state	state	PROPN
gs-4062	23	56	medical	medical	PROPN
gs-4062	23	57	university	university	NOUN
gs-4062	23	58	,	,	PUNCT
gs-4062	23	59	faculty	faculty	NOUN
gs-4062	23	60	of	of	ADP
gs-4062	23	61	public	public	ADJ
gs-4062	23	62	health	health	NOUN
gs-4062	23	63	;	;	PUNCT
gs-4062	23	64	department	department	NOUN
gs-4062	23	65	of	of	ADP
gs-4062	23	66	hygiene	hygiene	NOUN
gs-4062	23	67	and	and	CCONJ
gs-4062	23	68	medical	medical	ADJ
gs-4062	23	69	ecology	ecology	NOUN
gs-4062	23	70	,	,	PUNCT
gs-4062	23	71	tbilisi	tbilisi	PROPN
gs-4062	23	72	,	,	PUNCT
gs-4062	23	73	georgia	georgia	PROPN
gs-4062	23	74	.	.	PUNCT
gs-4062	24	1	https://orcid.org/0000-0003-06865227	https://orcid.org/0000-0003-06865227	PROPN
gs-4062	24	2	19	19	NUM
gs-4062	24	3	.	.	PUNCT
gs-4062	25	1	md	md	PROPN
gs-4062	25	2	,	,	PUNCT
gs-4062	25	3	phd	phd	NOUN
gs-4062	25	4	,	,	PUNCT
gs-4062	25	5	doctor	doctor	NOUN
gs-4062	25	6	of	of	ADP
gs-4062	25	7	medical	medical	ADJ
gs-4062	25	8	sciences	science	NOUN
gs-4062	25	9	,	,	PUNCT
gs-4062	25	10	professor	professor	NOUN
gs-4062	25	11	of	of	ADP
gs-4062	25	12	tbilisi	tbilisi	PROPN
gs-4062	25	13	state	state	PROPN
gs-4062	25	14	medical	medical	PROPN
gs-4062	25	15	university	university	PROPN
gs-4062	25	16	,	,	PUNCT
gs-4062	25	17	department	department	NOUN
gs-4062	25	18	of	of	ADP
gs-4062	25	19	public	public	ADJ
gs-4062	25	20	health	health	NOUN
gs-4062	25	21	,	,	PUNCT
gs-4062	25	22	health	health	NOUN
gs-4062	25	23	care	care	NOUN
gs-4062	25	24	management	management	NOUN
gs-4062	25	25	,	,	PUNCT
gs-4062	25	26	policy	policy	NOUN
gs-4062	25	27	and	and	CCONJ
gs-4062	25	28	economy	economy	NOUN
gs-4062	25	29	,	,	PUNCT
gs-4062	25	30	tbilisi	tbilisi	PROPN
gs-4062	25	31	,	,	PUNCT
gs-4062	25	32	georgia	georgia	PROPN
gs-4062	25	33	.	.	PUNCT
gs-4062	26	1	20	20	NUM
gs-4062	26	2	.	.	X
gs-4062	27	1	md	md	PROPN
gs-4062	27	2	,	,	PUNCT
gs-4062	27	3	phd	phd	NOUN
gs-4062	27	4	,	,	PUNCT
gs-4062	27	5	doctor	doctor	NOUN
gs-4062	27	6	of	of	ADP
gs-4062	27	7	medical	medical	ADJ
gs-4062	27	8	sciences	science	NOUN
gs-4062	27	9	,	,	PUNCT
gs-4062	27	10	academician	academician	NOUN
gs-4062	27	11	,	,	PUNCT
gs-4062	27	12	professor	professor	NOUN
gs-4062	27	13	of	of	ADP
gs-4062	27	14	tbilisi	tbilisi	PROPN
gs-4062	27	15	state	state	PROPN
gs-4062	27	16	medical	medical	PROPN
gs-4062	27	17	university	university	PROPN
gs-4062	27	18	,	,	PUNCT
gs-4062	27	19	dean	dean	NOUN
gs-4062	27	20	of	of	ADP
gs-4062	27	21	the	the	DET
gs-4062	27	22	faculty	faculty	NOUN
gs-4062	27	23	of	of	ADP
gs-4062	27	24	public	public	ADJ
gs-4062	27	25	health	health	NOUN
gs-4062	27	26	,	,	PUNCT
gs-4062	27	27	head	head	NOUN
gs-4062	27	28	of	of	ADP
gs-4062	27	29	the	the	DET
gs-4062	27	30	department	department	NOUN
gs-4062	27	31	of	of	ADP
gs-4062	27	32	nutrition	nutrition	NOUN
gs-4062	27	33	,	,	PUNCT
gs-4062	27	34	aging	age	VERB
gs-4062	27	35	medicine	medicine	NOUN
gs-4062	27	36	,	,	PUNCT
gs-4062	27	37	environmental	environmental	ADJ
gs-4062	27	38	and	and	CCONJ
gs-4062	27	39	occupational	occupational	ADJ
gs-4062	27	40	health	health	NOUN
gs-4062	27	41	,	,	PUNCT
gs-4062	27	42	tbilisi	tbilisi	PROPN
gs-4062	27	43	,	,	PUNCT
gs-4062	27	44	georgia	georgia	PROPN
gs-4062	27	45	.	.	PUNCT
gs-4062	28	1	corresponding	correspond	VERB
gs-4062	28	2	author	author	NOUN
gs-4062	28	3	:	:	PUNCT
gs-4062	28	4	dr	dr	PROPN
gs-4062	28	5	.	.	PROPN
gs-4062	28	6	professor	professor	PROPN
gs-4062	28	7	nodar	nodar	PROPN
gs-4062	28	8	sulashvili	sulashvili	PROPN
gs-4062	28	9	mail	mail	NOUN
gs-4062	28	10	:	:	PUNCT
gs-4062	28	11	n.sulashvili@ug.edu.ge	n.sulashvili@ug.edu.ge	NOUN
gs-4062	28	12	mob	mob	NOUN
gs-4062	28	13	:	:	PUNCT
gs-4062	29	1	+995	+995	ADJ
gs-4062	29	2	-	-	ADJ
gs-4062	29	3	597	597	NUM
gs-4062	29	4	-	-	PUNCT
gs-4062	29	5	12	12	NUM
gs-4062	29	6	-	-	PUNCT
gs-4062	29	7	17	17	NUM
gs-4062	29	8	-	-	SYM
gs-4062	29	9	28	28	NUM
gs-4062	29	10	abstract	abstract	NOUN
gs-4062	29	11	the	the	DET
gs-4062	29	12	therapeutic	therapeutic	ADJ
gs-4062	29	13	landscape	landscape	NOUN
gs-4062	29	14	for	for	ADP
gs-4062	29	15	human	human	ADJ
gs-4062	29	16	immunodeficiency	immunodeficiency	NOUN
gs-4062	29	17	virus	virus	NOUN
gs-4062	29	18	(	(	PUNCT
gs-4062	29	19	hiv	hiv	NOUN
gs-4062	29	20	)	)	PUNCT
gs-4062	29	21	infection	infection	NOUN
gs-4062	29	22	has	have	AUX
gs-4062	29	23	undergone	undergo	VERB
gs-4062	29	24	a	a	DET
gs-4062	29	25	profound	profound	ADJ
gs-4062	29	26	and	and	CCONJ
gs-4062	29	27	revolutionary	revolutionary	ADJ
gs-4062	29	28	transformation	transformation	NOUN
gs-4062	29	29	over	over	ADP
gs-4062	29	30	the	the	DET
gs-4062	29	31	past	past	ADJ
gs-4062	29	32	four	four	NUM
gs-4062	29	33	decades	decade	NOUN
gs-4062	29	34	.	.	PUNCT
gs-4062	30	1	from	from	ADP
gs-4062	30	2	a	a	DET
gs-4062	30	3	universally	universally	ADV
gs-4062	30	4	fatal	fatal	ADJ
gs-4062	30	5	diagnosis	diagnosis	NOUN
gs-4062	30	6	to	to	ADP
gs-4062	30	7	a	a	DET
gs-4062	30	8	manageable	manageable	ADJ
gs-4062	30	9	chronic	chronic	ADJ
gs-4062	30	10	condition	condition	NOUN
gs-4062	30	11	,	,	PUNCT
gs-4062	30	12	this	this	DET
gs-4062	30	13	evolution	evolution	NOUN
gs-4062	30	14	is	be	AUX
gs-4062	30	15	fundamentally	fundamentally	ADV
gs-4062	30	16	anchored	anchor	VERB
gs-4062	30	17	in	in	ADP
gs-4062	30	18	the	the	DET
gs-4062	30	19	relentless	relentless	ADJ
gs-4062	30	20	innovation	innovation	NOUN
gs-4062	30	21	of	of	ADP
gs-4062	30	22	antiretroviral	antiretroviral	ADJ
gs-4062	30	23	therapy	therapy	NOUN
gs-4062	30	24	(	(	PUNCT
gs-4062	30	25	art	art	NOUN
gs-4062	30	26	)	)	PUNCT
gs-4062	30	27	.	.	PUNCT
gs-4062	31	1	the	the	DET
gs-4062	31	2	scientific	scientific	ADJ
gs-4062	31	3	discourse	discourse	NOUN
gs-4062	31	4	surrounding	surround	VERB
gs-4062	31	5	new	new	ADJ
gs-4062	31	6	antiretroviral	antiretroviral	ADJ
gs-4062	31	7	medicines	medicine	NOUN
gs-4062	31	8	represents	represent	VERB
gs-4062	31	9	a	a	DET
gs-4062	31	10	dynamic	dynamic	ADJ
gs-4062	31	11	and	and	CCONJ
gs-4062	31	12	critical	critical	ADJ
gs-4062	31	13	nexus	nexus	NOUN
gs-4062	31	14	of	of	ADP
gs-4062	31	15	virology	virology	NOUN
gs-4062	31	16	,	,	PUNCT
gs-4062	31	17	pharmacology	pharmacology	NOUN
gs-4062	31	18	,	,	PUNCT
gs-4062	31	19	medicinal	medicinal	ADJ
gs-4062	31	20	chemistry	chemistry	NOUN
gs-4062	31	21	,	,	PUNCT
gs-4062	31	22	and	and	CCONJ
gs-4062	31	23	clinical	clinical	ADJ
gs-4062	31	24	medicine	medicine	NOUN
gs-4062	31	25	.	.	PUNCT
gs-4062	32	1	this	this	DET
gs-4062	32	2	discourse	discourse	NOUN
gs-4062	32	3	manifests	manifest	VERB
gs-4062	32	4	not	not	PART
gs-4062	32	5	as	as	ADP
gs-4062	32	6	a	a	DET
gs-4062	32	7	singular	singular	ADJ
gs-4062	32	8	event	event	NOUN
gs-4062	32	9	but	but	CCONJ
gs-4062	32	10	as	as	ADP
gs-4062	32	11	a	a	DET
gs-4062	32	12	continuous	continuous	ADJ
gs-4062	32	13	,	,	PUNCT
gs-4062	32	14	multi	multi	ADJ
gs-4062	32	15	-	-	ADJ
gs-4062	32	16	faceted	faceted	ADJ
gs-4062	32	17	process	process	NOUN
gs-4062	32	18	that	that	PRON
gs-4062	32	19	scrutinizes	scrutinize	VERB
gs-4062	32	20	every	every	DET
gs-4062	32	21	aspect	aspect	NOUN
gs-4062	32	22	of	of	ADP
gs-4062	32	23	a	a	DET
gs-4062	32	24	drug	drug	NOUN
gs-4062	32	25	's	's	PART
gs-4062	32	26	journey	journey	NOUN
gs-4062	32	27	from	from	ADP
gs-4062	32	28	molecular	molecular	ADJ
gs-4062	32	29	concept	concept	NOUN
gs-4062	32	30	to	to	ADP
gs-4062	32	31	clinical	clinical	ADJ
gs-4062	32	32	cornerstone	cornerstone	NOUN
gs-4062	32	33	.	.	PUNCT
gs-4062	33	1	this	this	DET
gs-4062	33	2	abstract	abstract	NOUN
gs-4062	33	3	aims	aim	VERB
gs-4062	33	4	to	to	PART
gs-4062	33	5	synthesize	synthesize	VERB
gs-4062	33	6	the	the	DET
gs-4062	33	7	core	core	ADJ
gs-4062	33	8	elements	element	NOUN
gs-4062	33	9	of	of	ADP
gs-4062	33	10	this	this	DET
gs-4062	33	11	scientific	scientific	ADJ
gs-4062	33	12	discussion	discussion	NOUN
gs-4062	33	13	,	,	PUNCT
gs-4062	33	14	focusing	focus	VERB
gs-4062	33	15	on	on	ADP
gs-4062	33	16	the	the	DET
gs-4062	33	17	classification	classification	NOUN
gs-4062	33	18	,	,	PUNCT
gs-4062	33	19	clinical	clinical	ADJ
gs-4062	33	20	applications	application	NOUN
gs-4062	33	21	,	,	PUNCT
gs-4062	33	22	and	and	CCONJ
gs-4062	33	23	distinctive	distinctive	ADJ
gs-4062	33	24	features	feature	NOUN
gs-4062	33	25	,	,	PUNCT
gs-4062	33	26	mechanisms	mechanism	NOUN
gs-4062	33	27	of	of	ADP
gs-4062	33	28	action	action	NOUN
gs-4062	33	29	,	,	PUNCT
gs-4062	33	30	pharmacological	pharmacological	ADJ
gs-4062	33	31	profiles	profile	NOUN
gs-4062	33	32	,	,	PUNCT
gs-4062	33	33	therapeutic	therapeutic	ADJ
gs-4062	33	34	effects	effect	NOUN
gs-4062	33	35	,	,	PUNCT
gs-4062	33	36	and	and	CCONJ
gs-4062	33	37	associated	associated	ADJ
gs-4062	33	38	toxicities	toxicity	NOUN
gs-4062	33	39	of	of	ADP
gs-4062	33	40	the	the	DET
gs-4062	33	41	newest	new	ADJ
gs-4062	33	42	generation	generation	NOUN
gs-4062	33	43	of	of	ADP
gs-4062	33	44	anti	anti	ADJ
gs-4062	33	45	-	-	ADJ
gs-4062	33	46	hiv	hiv	ADJ
gs-4062	33	47	agents	agent	NOUN
gs-4062	33	48	.	.	PUNCT
gs-4062	34	1	the	the	DET
gs-4062	34	2	evolution	evolution	NOUN
gs-4062	34	3	of	of	ADP
gs-4062	34	4	art	art	NOUN
gs-4062	34	5	has	have	AUX
gs-4062	34	6	progressively	progressively	ADV
gs-4062	34	7	shifted	shift	VERB
gs-4062	34	8	from	from	ADP
gs-4062	34	9	merely	merely	ADV
gs-4062	34	10	suppressing	suppress	VERB
gs-4062	34	11	viral	viral	ADJ
gs-4062	34	12	replication	replication	NOUN
gs-4062	34	13	to	to	ADP
gs-4062	34	14	emphasizing	emphasize	VERB
gs-4062	34	15	long	long	ADJ
gs-4062	34	16	-	-	PUNCT
gs-4062	34	17	term	term	NOUN
gs-4062	34	18	tolerability	tolerability	NOUN
gs-4062	34	19	,	,	PUNCT
gs-4062	34	20	adherence	adherence	NOUN
gs-4062	34	21	-	-	PUNCT
gs-4062	34	22	friendly	friendly	ADJ
gs-4062	34	23	regimens	regimen	NOUN
gs-4062	34	24	,	,	PUNCT
gs-4062	34	25	and	and	CCONJ
gs-4062	34	26	the	the	DET
gs-4062	34	27	mitigation	mitigation	NOUN
gs-4062	34	28	of	of	ADP
gs-4062	34	29	cumulative	cumulative	ADJ
gs-4062	34	30	toxicities	toxicity	NOUN
gs-4062	34	31	,	,	PUNCT
gs-4062	34	32	goals	goal	NOUN
gs-4062	34	33	that	that	PRON
gs-4062	34	34	are	be	AUX
gs-4062	34	35	directly	directly	ADV
gs-4062	34	36	addressed	address	VERB
gs-4062	34	37	by	by	ADP
gs-4062	34	38	these	these	DET
gs-4062	34	39	novel	novel	ADJ
gs-4062	34	40	compounds	compound	NOUN
gs-4062	34	41	.	.	PUNCT
gs-4062	35	1	the	the	DET
gs-4062	35	2	classification	classification	NOUN
gs-4062	35	3	of	of	ADP
gs-4062	35	4	antiretroviral	antiretroviral	ADJ
gs-4062	35	5	drugs	drug	NOUN
gs-4062	35	6	has	have	AUX
gs-4062	35	7	traditionally	traditionally	ADV
gs-4062	35	8	been	be	AUX
gs-4062	35	9	based	base	VERB
gs-4062	35	10	on	on	ADP
gs-4062	35	11	their	their	PRON
gs-4062	35	12	molecular	molecular	ADJ
gs-4062	35	13	target	target	NOUN
gs-4062	35	14	within	within	ADP
gs-4062	35	15	the	the	DET
gs-4062	35	16	hiv	hiv	PROPN
gs-4062	35	17	replication	replication	NOUN
gs-4062	35	18	cycle	cycle	NOUN
gs-4062	35	19	.	.	PUNCT
gs-4062	36	1	the	the	DET
gs-4062	36	2	newest	new	ADJ
gs-4062	36	3	agents	agent	NOUN
gs-4062	36	4	both	both	CCONJ
gs-4062	36	5	reinforce	reinforce	VERB
gs-4062	36	6	and	and	CCONJ
gs-4062	36	7	expand	expand	VERB
gs-4062	36	8	this	this	DET
gs-4062	36	9	taxonomic	taxonomic	ADJ
gs-4062	36	10	structure	structure	NOUN
gs-4062	36	11	.	.	PUNCT
gs-4062	37	1	the	the	DET
gs-4062	37	2	established	establish	VERB
gs-4062	37	3	classes	class	NOUN
gs-4062	37	4	—	—	PUNCT
gs-4062	37	5	nucleoside	nucleoside	ADV
gs-4062	37	6	reverse	reverse	ADJ
gs-4062	37	7	transcriptase	transcriptase	NOUN
gs-4062	37	8	inhibitors	inhibitor	NOUN
gs-4062	37	9	(	(	PUNCT
gs-4062	37	10	nrtis	nrtis	PROPN
gs-4062	37	11	)	)	PUNCT
gs-4062	37	12	,	,	PUNCT
gs-4062	37	13	non	non	ADJ
gs-4062	37	14	-	-	ADJ
gs-4062	37	15	nucleoside	nucleoside	ADJ
gs-4062	37	16	reverse	reverse	ADJ
gs-4062	37	17	transcriptase	transcriptase	NOUN
gs-4062	37	18	inhibitors	inhibitor	NOUN
gs-4062	37	19	(	(	PUNCT
gs-4062	37	20	nnrtis	nnrtis	ADJ
gs-4062	37	21	)	)	PUNCT
gs-4062	37	22	,	,	PUNCT
gs-4062	37	23	protease	protease	NOUN
gs-4062	37	24	inhibitors	inhibitor	NOUN
gs-4062	37	25	(	(	PUNCT
gs-4062	37	26	pis	pis	NOUN
gs-4062	37	27	)	)	PUNCT
gs-4062	37	28	,	,	PUNCT
gs-4062	37	29	integrase	integrase	NOUN
gs-4062	37	30	strand	strand	NOUN
gs-4062	37	31	transfer	transfer	NOUN
gs-4062	37	32	inhibitors	inhibitor	NOUN
gs-4062	37	33	(	(	PUNCT
gs-4062	37	34	instis	instis	NOUN
gs-4062	37	35	)	)	PUNCT
gs-4062	37	36	,	,	PUNCT
gs-4062	37	37	entry	entry	NOUN
gs-4062	37	38	inhibitors	inhibitor	NOUN
gs-4062	37	39	(	(	PUNCT
gs-4062	37	40	including	include	VERB
gs-4062	37	41	ccr5	ccr5	NOUN
gs-4062	37	42	antagonists	antagonist	NOUN
gs-4062	37	43	and	and	CCONJ
gs-4062	37	44	post	post	ADJ
gs-4062	37	45	-	-	ADJ
gs-4062	37	46	attachment	attachment	ADJ
gs-4062	37	47	inhibitors	inhibitor	NOUN
gs-4062	37	48	)	)	PUNCT
gs-4062	37	49	,	,	PUNCT
gs-4062	37	50	and	and	CCONJ
gs-4062	37	51	pharmacokinetic	pharmacokinetic	ADJ
gs-4062	37	52	enhancers	enhancer	NOUN
gs-4062	37	53	(	(	PUNCT
gs-4062	37	54	e.g.	e.g.	ADV
gs-4062	37	55	,	,	PUNCT
gs-4062	37	56	cobicistat)—remain	cobicistat)—remain	ADV
gs-4062	37	57	relevant	relevant	ADJ
gs-4062	37	58	.	.	PUNCT
gs-4062	38	1	however	however	ADV
gs-4062	38	2	,	,	PUNCT
gs-4062	38	3	the	the	DET
gs-4062	38	4	most	most	ADV
gs-4062	38	5	significant	significant	ADJ
gs-4062	38	6	recent	recent	ADJ
gs-4062	38	7	advancements	advancement	NOUN
gs-4062	38	8	have	have	AUX
gs-4062	38	9	emerged	emerge	VERB
gs-4062	38	10	within	within	ADP
gs-4062	38	11	the	the	DET
gs-4062	38	12	insti	insti	NOUN
gs-4062	38	13	class	class	NOUN
gs-4062	38	14	and	and	CCONJ
gs-4062	38	15	have	have	AUX
gs-4062	38	16	pioneered	pioneer	VERB
gs-4062	38	17	entirely	entirely	ADV
gs-4062	38	18	new	new	ADJ
gs-4062	38	19	mechanisms	mechanism	NOUN
gs-4062	38	20	,	,	PUNCT
gs-4062	38	21	most	most	ADV
gs-4062	38	22	notably	notably	ADV
gs-4062	38	23	with	with	ADP
gs-4062	38	24	the	the	DET
gs-4062	38	25	advent	advent	NOUN
gs-4062	38	26	of	of	ADP
gs-4062	38	27	attachment	attachment	ADJ
gs-4062	38	28	inhibitors	inhibitor	NOUN
gs-4062	38	29	and	and	CCONJ
gs-4062	38	30	capsid	capsid	VERB
gs-4062	38	31	inhibitors	inhibitor	NOUN
gs-4062	38	32	.	.	PUNCT
gs-4062	39	1	the	the	DET
gs-4062	39	2	scientific	scientific	ADJ
gs-4062	39	3	discussion	discussion	NOUN
gs-4062	39	4	on	on	ADP
gs-4062	39	5	classification	classification	NOUN
gs-4062	39	6	is	be	AUX
gs-4062	39	7	no	no	ADV
gs-4062	39	8	longer	long	ADV
gs-4062	39	9	static	static	ADJ
gs-4062	39	10	;	;	PUNCT
gs-4062	39	11	it	it	PRON
gs-4062	39	12	now	now	ADV
gs-4062	39	13	actively	actively	ADV
gs-4062	39	14	debates	debate	VERB
gs-4062	39	15	the	the	DET
gs-4062	39	16	placement	placement	NOUN
gs-4062	39	17	of	of	ADP
gs-4062	39	18	novel	novel	ADJ
gs-4062	39	19	agents	agent	NOUN
gs-4062	39	20	with	with	ADP
gs-4062	39	21	multi	multi	ADJ
gs-4062	39	22	-	-	ADJ
gs-4062	39	23	modal	modal	ADJ
gs-4062	39	24	mechanisms	mechanism	NOUN
gs-4062	39	25	,	,	PUNCT
gs-4062	39	26	georgian	georgian	NOUN
gs-4062	39	27	scientists/	scientists/	NUM
gs-4062	39	28	.	.	PUNCT
gs-4062	40	1	7	7	NUM
gs-4062	40	2	n	n	PRON
gs-4062	40	3	3	3	NUM
gs-4062	40	4	,	,	PUNCT
gs-4062	40	5	2025	2025	NUM
gs-4062	40	6	524	524	NUM
gs-4062	40	7	questioning	question	VERB
gs-4062	40	8	whether	whether	SCONJ
gs-4062	40	9	traditional	traditional	ADJ
gs-4062	40	10	silos	silo	NOUN
gs-4062	40	11	are	be	AUX
gs-4062	40	12	sufficient	sufficient	ADJ
gs-4062	40	13	or	or	CCONJ
gs-4062	40	14	if	if	SCONJ
gs-4062	40	15	a	a	DET
gs-4062	40	16	new	new	ADJ
gs-4062	40	17	,	,	PUNCT
gs-4062	40	18	more	more	ADV
gs-4062	40	19	nuanced	nuanced	ADJ
gs-4062	40	20	system	system	NOUN
gs-4062	40	21	based	base	VERB
gs-4062	40	22	on	on	ADP
gs-4062	40	23	mechanism	mechanism	NOUN
gs-4062	40	24	and	and	CCONJ
gs-4062	40	25	genetic	genetic	ADJ
gs-4062	40	26	barrier	barrier	NOUN
gs-4062	40	27	to	to	ADP
gs-4062	40	28	resistance	resistance	NOUN
gs-4062	40	29	is	be	AUX
gs-4062	40	30	required	require	VERB
gs-4062	40	31	.	.	PUNCT
gs-4062	41	1	the	the	DET
gs-4062	41	2	clinical	clinical	ADJ
gs-4062	41	3	use	use	NOUN
gs-4062	41	4	of	of	ADP
gs-4062	41	5	new	new	ADJ
gs-4062	41	6	antiretrovirals	antiretroviral	NOUN
gs-4062	41	7	is	be	AUX
gs-4062	41	8	dictated	dictate	VERB
gs-4062	41	9	by	by	ADP
gs-4062	41	10	the	the	DET
gs-4062	41	11	overarching	overarching	ADJ
gs-4062	41	12	goals	goal	NOUN
gs-4062	41	13	of	of	ADP
gs-4062	41	14	modern	modern	ADJ
gs-4062	41	15	hiv	hiv	PROPN
gs-4062	41	16	management	management	NOUN
gs-4062	41	17	:	:	PUNCT
gs-4062	41	18	achieving	achieve	VERB
gs-4062	41	19	and	and	CCONJ
gs-4062	41	20	maintaining	maintain	VERB
gs-4062	41	21	virological	virological	ADJ
gs-4062	41	22	suppression	suppression	NOUN
gs-4062	41	23	(	(	PUNCT
gs-4062	41	24	hiv-1	hiv-1	X
gs-4062	41	25	rna	rna	NOUN
gs-4062	41	26	<	<	NOUN
gs-4062	41	27	50	50	NUM
gs-4062	41	28	copies	copy	NOUN
gs-4062	41	29	/	/	SYM
gs-4062	41	30	ml	ml	NOUN
gs-4062	41	31	)	)	PUNCT
gs-4062	41	32	,	,	PUNCT
gs-4062	41	33	restoring	restore	VERB
gs-4062	41	34	and	and	CCONJ
gs-4062	41	35	preserving	preserve	VERB
gs-4062	41	36	immunological	immunological	ADJ
gs-4062	41	37	function	function	NOUN
gs-4062	41	38	(	(	PUNCT
gs-4062	41	39	increasing	increase	VERB
gs-4062	41	40	cd4	cd4	PROPN
gs-4062	41	41	+	+	PROPN
gs-4062	41	42	t	t	PROPN
gs-4062	41	43	-	-	PUNCT
gs-4062	41	44	cell	cell	NOUN
gs-4062	41	45	count	count	NOUN
gs-4062	41	46	)	)	PUNCT
gs-4062	41	47	,	,	PUNCT
gs-4062	41	48	reducing	reduce	VERB
gs-4062	41	49	hiv	hiv	NOUN
gs-4062	41	50	-	-	PUNCT
gs-4062	41	51	associated	associate	VERB
gs-4062	41	52	morbidity	morbidity	NOUN
gs-4062	41	53	and	and	CCONJ
gs-4062	41	54	mortality	mortality	NOUN
gs-4062	41	55	,	,	PUNCT
gs-4062	41	56	and	and	CCONJ
gs-4062	41	57	preventing	prevent	VERB
gs-4062	41	58	hiv	hiv	PROPN
gs-4062	41	59	transmission	transmission	NOUN
gs-4062	41	60	.	.	PUNCT
gs-4062	42	1	newer	new	ADJ
gs-4062	42	2	drugs	drug	NOUN
gs-4062	42	3	are	be	AUX
gs-4062	42	4	integral	integral	ADJ
gs-4062	42	5	to	to	ADP
gs-4062	42	6	first	first	ADJ
gs-4062	42	7	-	-	PUNCT
gs-4062	42	8	line	line	NOUN
gs-4062	42	9	therapy	therapy	NOUN
gs-4062	42	10	,	,	PUNCT
gs-4062	42	11	treatment	treatment	NOUN
gs-4062	42	12	simplification	simplification	NOUN
gs-4062	42	13	,	,	PUNCT
gs-4062	42	14	and	and	CCONJ
gs-4062	42	15	the	the	DET
gs-4062	42	16	management	management	NOUN
gs-4062	42	17	of	of	ADP
gs-4062	42	18	highly	highly	ADV
gs-4062	42	19	treatment	treatment	NOUN
gs-4062	42	20	-	-	PUNCT
gs-4062	42	21	experienced	experience	VERB
gs-4062	42	22	patients	patient	NOUN
gs-4062	42	23	with	with	ADP
gs-4062	42	24	multidrugresistant	multidrugresistant	ADJ
gs-4062	42	25	virus	virus	NOUN
gs-4062	42	26	.	.	PUNCT
gs-4062	43	1	the	the	DET
gs-4062	43	2	scientific	scientific	ADJ
gs-4062	43	3	conversation	conversation	NOUN
gs-4062	43	4	here	here	ADV
gs-4062	43	5	is	be	AUX
gs-4062	43	6	vibrant	vibrant	ADJ
gs-4062	43	7	,	,	PUNCT
gs-4062	43	8	centering	center	VERB
gs-4062	43	9	on	on	ADP
gs-4062	43	10	the	the	DET
gs-4062	43	11	comparative	comparative	ADJ
gs-4062	43	12	efficacy	efficacy	NOUN
gs-4062	43	13	of	of	ADP
gs-4062	43	14	new	new	ADJ
gs-4062	43	15	regimens	regimen	NOUN
gs-4062	43	16	,	,	PUNCT
gs-4062	43	17	often	often	ADV
gs-4062	43	18	head	head	VERB
gs-4062	43	19	-	-	PUNCT
gs-4062	43	20	to	to	ADP
gs-4062	43	21	-	-	PUNCT
gs-4062	43	22	head	head	NOUN
gs-4062	43	23	clinical	clinical	ADJ
gs-4062	43	24	trials	trial	NOUN
gs-4062	43	25	pitting	pitting	NOUN
gs-4062	43	26	established	establish	VERB
gs-4062	43	27	gold	gold	NOUN
gs-4062	43	28	standards	standard	NOUN
gs-4062	43	29	against	against	ADP
gs-4062	43	30	newer	new	ADJ
gs-4062	43	31	contenders	contender	NOUN
gs-4062	43	32	.	.	PUNCT
gs-4062	44	1	for	for	ADP
gs-4062	44	2	instance	instance	NOUN
gs-4062	44	3	,	,	PUNCT
gs-4062	44	4	the	the	DET
gs-4062	44	5	debate	debate	NOUN
gs-4062	44	6	around	around	ADP
gs-4062	44	7	second	second	ADJ
gs-4062	44	8	-	-	PUNCT
gs-4062	44	9	generation	generation	NOUN
gs-4062	44	10	instis	instis	NOUN
gs-4062	44	11	like	like	ADP
gs-4062	44	12	dolutegravir	dolutegravir	NOUN
gs-4062	44	13	and	and	CCONJ
gs-4062	44	14	bictegravir	bictegravir	PROPN
gs-4062	44	15	versus	versus	ADP
gs-4062	44	16	first	first	ADJ
gs-4062	44	17	-	-	PUNCT
gs-4062	44	18	generation	generation	NOUN
gs-4062	44	19	agents	agent	NOUN
gs-4062	44	20	like	like	ADP
gs-4062	44	21	elvitegravir	elvitegravir	PROPN
gs-4062	44	22	and	and	CCONJ
gs-4062	44	23	raltegravir	raltegravir	PROPN
gs-4062	44	24	focuses	focus	VERB
gs-4062	44	25	on	on	ADP
gs-4062	44	26	superior	superior	ADJ
gs-4062	44	27	resistance	resistance	NOUN
gs-4062	44	28	profiles	profile	NOUN
gs-4062	44	29	and	and	CCONJ
gs-4062	44	30	higher	high	ADJ
gs-4062	44	31	genetic	genetic	ADJ
gs-4062	44	32	barriers	barrier	NOUN
gs-4062	44	33	to	to	ADP
gs-4062	44	34	resistance	resistance	NOUN
gs-4062	44	35	.	.	PUNCT
gs-4062	45	1	furthermore	furthermore	ADV
gs-4062	45	2	,	,	PUNCT
gs-4062	45	3	the	the	DET
gs-4062	45	4	development	development	NOUN
gs-4062	45	5	of	of	ADP
gs-4062	45	6	longacting	longacte	VERB
gs-4062	45	7	injectable	injectable	ADJ
gs-4062	45	8	formulations	formulation	NOUN
gs-4062	45	9	,	,	PUNCT
gs-4062	45	10	such	such	ADJ
gs-4062	45	11	as	as	ADP
gs-4062	45	12	the	the	DET
gs-4062	45	13	combination	combination	NOUN
gs-4062	45	14	of	of	ADP
gs-4062	45	15	the	the	DET
gs-4062	45	16	novel	novel	NOUN
gs-4062	45	17	insti	insti	NOUN
gs-4062	45	18	cabotegravir	cabotegravir	PROPN
gs-4062	45	19	and	and	CCONJ
gs-4062	45	20	the	the	DET
gs-4062	45	21	nnrti	nnrti	NOUN
gs-4062	45	22	rilpivirine	rilpivirine	NOUN
gs-4062	45	23	,	,	PUNCT
gs-4062	45	24	has	have	AUX
gs-4062	45	25	ignited	ignite	VERB
gs-4062	45	26	discussion	discussion	NOUN
gs-4062	45	27	on	on	ADP
gs-4062	45	28	their	their	PRON
gs-4062	45	29	use	use	NOUN
gs-4062	45	30	as	as	ADP
gs-4062	45	31	maintenance	maintenance	NOUN
gs-4062	45	32	therapy	therapy	NOUN
gs-4062	45	33	,	,	PUNCT
gs-4062	45	34	potentially	potentially	ADV
gs-4062	45	35	replacing	replace	VERB
gs-4062	45	36	daily	daily	ADJ
gs-4062	45	37	oral	oral	ADJ
gs-4062	45	38	regimens	regimen	NOUN
gs-4062	45	39	and	and	CCONJ
gs-4062	45	40	addressing	address	VERB
gs-4062	45	41	adherence	adherence	NOUN
gs-4062	45	42	challenges	challenge	NOUN
gs-4062	45	43	,	,	PUNCT
gs-4062	45	44	a	a	DET
gs-4062	45	45	paradigm	paradigm	NOUN
gs-4062	45	46	shift	shift	NOUN
gs-4062	45	47	in	in	ADP
gs-4062	45	48	clinical	clinical	ADJ
gs-4062	45	49	practice	practice	NOUN
gs-4062	45	50	.	.	PUNCT
gs-4062	46	1	introduction	introduction	NOUN
gs-4062	46	2	the	the	DET
gs-4062	46	3	human	human	ADJ
gs-4062	46	4	immunodeficiency	immunodeficiency	NOUN
gs-4062	46	5	virus	virus	NOUN
gs-4062	46	6	(	(	PUNCT
gs-4062	46	7	hiv	hiv	PROPN
gs-4062	46	8	)	)	PUNCT
gs-4062	46	9	pandemic	pandemic	NOUN
gs-4062	46	10	stands	stand	VERB
gs-4062	46	11	as	as	ADP
gs-4062	46	12	one	one	NUM
gs-4062	46	13	of	of	ADP
gs-4062	46	14	the	the	DET
gs-4062	46	15	most	most	ADV
gs-4062	46	16	profound	profound	ADJ
gs-4062	46	17	public	public	ADJ
gs-4062	46	18	health	health	NOUN
gs-4062	46	19	challenges	challenge	NOUN
gs-4062	46	20	in	in	ADP
gs-4062	46	21	modern	modern	ADJ
gs-4062	46	22	history	history	NOUN
gs-4062	46	23	,	,	PUNCT
gs-4062	46	24	a	a	DET
gs-4062	46	25	complex	complex	ADJ
gs-4062	46	26	saga	saga	NOUN
gs-4062	46	27	of	of	ADP
gs-4062	46	28	scientific	scientific	ADJ
gs-4062	46	29	discovery	discovery	NOUN
gs-4062	46	30	,	,	PUNCT
gs-4062	46	31	societal	societal	ADJ
gs-4062	46	32	struggle	struggle	NOUN
gs-4062	46	33	,	,	PUNCT
gs-4062	46	34	and	and	CCONJ
gs-4062	46	35	medical	medical	ADJ
gs-4062	46	36	innovation	innovation	NOUN
gs-4062	46	37	.	.	PUNCT
gs-4062	47	1	from	from	ADP
gs-4062	47	2	its	its	PRON
gs-4062	47	3	initial	initial	ADJ
gs-4062	47	4	identification	identification	NOUN
gs-4062	47	5	in	in	ADP
gs-4062	47	6	the	the	DET
gs-4062	47	7	early	early	ADJ
gs-4062	47	8	1980s	1980	NOUN
gs-4062	47	9	as	as	ADP
gs-4062	47	10	a	a	DET
gs-4062	47	11	mysterious	mysterious	ADJ
gs-4062	47	12	and	and	CCONJ
gs-4062	47	13	invariable	invariable	ADJ
gs-4062	47	14	fatal	fatal	ADJ
gs-4062	47	15	agent	agent	NOUN
gs-4062	47	16	causing	cause	VERB
gs-4062	47	17	acquired	acquire	VERB
gs-4062	47	18	immunodeficiency	immunodeficiency	NOUN
gs-4062	47	19	syndrome	syndrome	NOUN
gs-4062	47	20	(	(	PUNCT
gs-4062	47	21	aids	aids	PROPN
gs-4062	47	22	)	)	PUNCT
gs-4062	47	23	,	,	PUNCT
gs-4062	47	24	hiv	hiv	PROPN
gs-4062	47	25	has	have	AUX
gs-4062	47	26	been	be	AUX
gs-4062	47	27	transformed	transform	VERB
gs-4062	47	28	into	into	ADP
gs-4062	47	29	a	a	DET
gs-4062	47	30	manageable	manageable	ADJ
gs-4062	47	31	chronic	chronic	ADJ
gs-4062	47	32	condition	condition	NOUN
gs-4062	47	33	through	through	ADP
gs-4062	47	34	the	the	DET
gs-4062	47	35	revolutionary	revolutionary	ADJ
gs-4062	47	36	development	development	NOUN
gs-4062	47	37	of	of	ADP
gs-4062	47	38	antiretroviral	antiretroviral	ADJ
gs-4062	47	39	therapy	therapy	NOUN
gs-4062	47	40	(	(	PUNCT
gs-4062	47	41	art	art	NOUN
gs-4062	47	42	)	)	PUNCT
gs-4062	47	43	.	.	PUNCT
gs-4062	48	1	this	this	DET
gs-4062	48	2	journey	journey	NOUN
gs-4062	48	3	,	,	PUNCT
gs-4062	48	4	spanning	span	VERB
gs-4062	48	5	over	over	ADP
gs-4062	48	6	four	four	NUM
gs-4062	48	7	decades	decade	NOUN
gs-4062	48	8	,	,	PUNCT
gs-4062	48	9	represents	represent	VERB
gs-4062	48	10	a	a	DET
gs-4062	48	11	triumph	triumph	NOUN
gs-4062	48	12	of	of	ADP
gs-4062	48	13	biomedical	biomedical	ADJ
gs-4062	48	14	research	research	NOUN
gs-4062	48	15	and	and	CCONJ
gs-4062	48	16	global	global	ADJ
gs-4062	48	17	health	health	NOUN
gs-4062	48	18	mobilization	mobilization	NOUN
gs-4062	48	19	.	.	PUNCT
gs-4062	49	1	the	the	DET
gs-4062	49	2	introduction	introduction	NOUN
gs-4062	49	3	of	of	ADP
gs-4062	49	4	combination	combination	NOUN
gs-4062	49	5	art	art	NOUN
gs-4062	49	6	in	in	ADP
gs-4062	49	7	the	the	DET
gs-4062	49	8	mid-1990s	mid-1990	NOUN
gs-4062	49	9	,	,	PUNCT
gs-4062	49	10	often	often	ADV
gs-4062	49	11	referred	refer	VERB
gs-4062	49	12	to	to	ADP
gs-4062	49	13	as	as	SCONJ
gs-4062	49	14	the	the	DET
gs-4062	49	15	"	"	PUNCT
gs-4062	49	16	lazarus	lazarus	PROPN
gs-4062	49	17	effect	effect	NOUN
gs-4062	49	18	"	"	PUNCT
gs-4062	49	19	for	for	ADP
gs-4062	49	20	its	its	PRON
gs-4062	49	21	ability	ability	NOUN
gs-4062	49	22	to	to	PART
gs-4062	49	23	bring	bring	VERB
gs-4062	49	24	patients	patient	NOUN
gs-4062	49	25	back	back	ADV
gs-4062	49	26	from	from	ADP
gs-4062	49	27	the	the	DET
gs-4062	49	28	brink	brink	NOUN
gs-4062	49	29	of	of	ADP
gs-4062	49	30	death	death	NOUN
gs-4062	49	31	,	,	PUNCT
gs-4062	49	32	marked	mark	VERB
gs-4062	49	33	the	the	DET
gs-4062	49	34	end	end	NOUN
gs-4062	49	35	of	of	ADP
gs-4062	49	36	the	the	DET
gs-4062	49	37	epidemic	epidemic	NOUN
gs-4062	49	38	's	's	PART
gs-4062	49	39	darkest	dark	ADJ
gs-4062	49	40	chapter	chapter	NOUN
gs-4062	49	41	.	.	PUNCT
gs-4062	50	1	however	however	ADV
gs-4062	50	2	,	,	PUNCT
gs-4062	50	3	this	this	PRON
gs-4062	50	4	was	be	AUX
gs-4062	50	5	not	not	PART
gs-4062	50	6	a	a	DET
gs-4062	50	7	conclusion	conclusion	NOUN
gs-4062	50	8	but	but	CCONJ
gs-4062	50	9	a	a	DET
gs-4062	50	10	new	new	ADJ
gs-4062	50	11	beginning	beginning	NOUN
gs-4062	50	12	—	—	PUNCT
gs-4062	50	13	the	the	DET
gs-4062	50	14	commencement	commencement	NOUN
gs-4062	50	15	of	of	ADP
gs-4062	50	16	an	an	DET
gs-4062	50	17	ongoing	ongoing	ADJ
gs-4062	50	18	evolution	evolution	NOUN
gs-4062	50	19	towards	towards	ADP
gs-4062	50	20	ever	ever	ADV
gs-4062	50	21	more	more	ADV
gs-4062	50	22	effective	effective	ADJ
gs-4062	50	23	,	,	PUNCT
gs-4062	50	24	tolerable	tolerable	ADJ
gs-4062	50	25	,	,	PUNCT
gs-4062	50	26	and	and	CCONJ
gs-4062	50	27	user	user	NOUN
gs-4062	50	28	-	-	PUNCT
gs-4062	50	29	friendly	friendly	ADJ
gs-4062	50	30	therapeutics	therapeutic	NOUN
gs-4062	50	31	.	.	PUNCT
gs-4062	51	1	the	the	DET
gs-4062	51	2	landscape	landscape	NOUN
gs-4062	51	3	of	of	ADP
gs-4062	51	4	hiv	hiv	PROPN
gs-4062	51	5	treatment	treatment	NOUN
gs-4062	51	6	is	be	AUX
gs-4062	51	7	now	now	ADV
gs-4062	51	8	undergoing	undergo	VERB
gs-4062	51	9	its	its	PRON
gs-4062	51	10	most	most	ADV
gs-4062	51	11	radical	radical	ADJ
gs-4062	51	12	transformation	transformation	NOUN
gs-4062	51	13	since	since	SCONJ
gs-4062	51	14	the	the	DET
gs-4062	51	15	advent	advent	NOUN
gs-4062	51	16	of	of	ADP
gs-4062	51	17	combination	combination	NOUN
gs-4062	51	18	therapy	therapy	NOUN
gs-4062	51	19	itself	itself	PRON
gs-4062	51	20	,	,	PUNCT
gs-4062	51	21	propelled	propel	VERB
gs-4062	51	22	by	by	ADP
gs-4062	51	23	a	a	DET
gs-4062	51	24	new	new	ADJ
gs-4062	51	25	generation	generation	NOUN
gs-4062	51	26	of	of	ADP
gs-4062	51	27	antiretroviral	antiretroviral	ADJ
gs-4062	51	28	agents	agent	NOUN
gs-4062	51	29	that	that	PRON
gs-4062	51	30	challenge	challenge	VERB
gs-4062	51	31	long	long	ADV
gs-4062	51	32	-	-	PUNCT
gs-4062	51	33	held	hold	VERB
gs-4062	51	34	paradigms	paradigm	NOUN
gs-4062	51	35	and	and	CCONJ
gs-4062	51	36	offer	offer	VERB
gs-4062	51	37	unprecedented	unprecedented	ADJ
gs-4062	51	38	hope	hope	NOUN
gs-4062	51	39	for	for	ADP
gs-4062	51	40	the	the	DET
gs-4062	51	41	future	future	NOUN
gs-4062	51	42	.	.	PUNCT
gs-4062	52	1	the	the	DET
gs-4062	52	2	historical	historical	ADJ
gs-4062	52	3	context	context	NOUN
gs-4062	52	4	of	of	ADP
gs-4062	52	5	hiv	hiv	PROPN
gs-4062	52	6	treatment	treatment	NOUN
gs-4062	52	7	is	be	AUX
gs-4062	52	8	essential	essential	ADJ
gs-4062	52	9	for	for	ADP
gs-4062	52	10	appreciating	appreciate	VERB
gs-4062	52	11	the	the	DET
gs-4062	52	12	magnitude	magnitude	NOUN
gs-4062	52	13	of	of	ADP
gs-4062	52	14	current	current	ADJ
gs-4062	52	15	advancements	advancement	NOUN
gs-4062	52	16	.	.	PUNCT
gs-4062	53	1	the	the	DET
gs-4062	53	2	first	first	ADJ
gs-4062	53	3	decade	decade	NOUN
gs-4062	53	4	of	of	ADP
gs-4062	53	5	the	the	DET
gs-4062	53	6	epidemic	epidemic	NOUN
gs-4062	53	7	was	be	AUX
gs-4062	53	8	characterized	characterize	VERB
gs-4062	53	9	by	by	ADP
gs-4062	53	10	fear	fear	NOUN
gs-4062	53	11	,	,	PUNCT
gs-4062	53	12	uncertainty	uncertainty	NOUN
gs-4062	53	13	,	,	PUNCT
gs-4062	53	14	and	and	CCONJ
gs-4062	53	15	therapeutic	therapeutic	ADJ
gs-4062	53	16	nihilism	nihilism	NOUN
gs-4062	53	17	.	.	PUNCT
gs-4062	54	1	the	the	DET
gs-4062	54	2	approval	approval	NOUN
gs-4062	54	3	of	of	ADP
gs-4062	54	4	zidovudine	zidovudine	PROPN
gs-4062	54	5	(	(	PUNCT
gs-4062	54	6	azt	azt	PROPN
gs-4062	54	7	)	)	PUNCT
gs-4062	54	8	in	in	ADP
gs-4062	54	9	1987	1987	NUM
gs-4062	54	10	offered	offer	VERB
gs-4062	54	11	a	a	DET
gs-4062	54	12	glimmer	glimmer	NOUN
gs-4062	54	13	of	of	ADP
gs-4062	54	14	hope	hope	NOUN
gs-4062	54	15	,	,	PUNCT
gs-4062	54	16	but	but	CCONJ
gs-4062	54	17	it	it	PRON
gs-4062	54	18	was	be	AUX
gs-4062	54	19	short	short	ADV
gs-4062	54	20	-	-	PUNCT
gs-4062	54	21	lived	live	VERB
gs-4062	54	22	as	as	SCONJ
gs-4062	54	23	the	the	DET
gs-4062	54	24	virus	virus	NOUN
gs-4062	54	25	rapidly	rapidly	ADV
gs-4062	54	26	developed	develop	VERB
gs-4062	54	27	resistance	resistance	NOUN
gs-4062	54	28	to	to	ADP
gs-4062	54	29	the	the	DET
gs-4062	54	30	single	single	ADJ
gs-4062	54	31	agent	agent	NOUN
gs-4062	54	32	.	.	PUNCT
gs-4062	55	1	the	the	DET
gs-4062	55	2	true	true	ADJ
gs-4062	55	3	turning	turning	NOUN
gs-4062	55	4	point	point	NOUN
gs-4062	55	5	arrived	arrive	VERB
gs-4062	55	6	with	with	ADP
gs-4062	55	7	the	the	DET
gs-4062	55	8	development	development	NOUN
gs-4062	55	9	of	of	ADP
gs-4062	55	10	protease	protease	NOUN
gs-4062	55	11	inhibitors	inhibitor	NOUN
gs-4062	55	12	and	and	CCONJ
gs-4062	55	13	the	the	DET
gs-4062	55	14	concept	concept	NOUN
gs-4062	55	15	of	of	ADP
gs-4062	55	16	highly	highly	ADV
gs-4062	55	17	active	active	ADJ
gs-4062	55	18	antiretroviral	antiretroviral	ADJ
gs-4062	55	19	therapy	therapy	NOUN
gs-4062	55	20	(	(	PUNCT
gs-4062	55	21	haart	haart	PROPN
gs-4062	55	22	)	)	PUNCT
gs-4062	55	23	in	in	ADP
gs-4062	55	24	1996	1996	NUM
gs-4062	55	25	.	.	PUNCT
gs-4062	56	1	this	this	DET
gs-4062	56	2	strategy	strategy	NOUN
gs-4062	56	3	of	of	ADP
gs-4062	56	4	combining	combine	VERB
gs-4062	56	5	drugs	drug	NOUN
gs-4062	56	6	from	from	ADP
gs-4062	56	7	at	at	ADV
gs-4062	56	8	least	least	ADV
gs-4062	56	9	two	two	NUM
gs-4062	56	10	different	different	ADJ
gs-4062	56	11	classes	class	NOUN
gs-4062	56	12	—	—	PUNCT
gs-4062	56	13	typically	typically	ADV
gs-4062	56	14	a	a	DET
gs-4062	56	15	protease	protease	NOUN
gs-4062	56	16	inhibitor	inhibitor	NOUN
gs-4062	56	17	or	or	CCONJ
gs-4062	56	18	a	a	DET
gs-4062	56	19	non	non	ADJ
gs-4062	56	20	-	-	ADJ
gs-4062	56	21	nucleoside	nucleoside	ADJ
gs-4062	56	22	reverse	reverse	ADJ
gs-4062	56	23	transcriptase	transcriptase	NOUN
gs-4062	56	24	inhibitor	inhibitor	NOUN
gs-4062	56	25	paired	pair	VERB
gs-4062	56	26	with	with	ADP
gs-4062	56	27	nucleoside	nucleoside	ADJ
gs-4062	56	28	reverse	reverse	ADJ
gs-4062	56	29	transcriptase	transcriptase	NOUN
gs-4062	56	30	inhibitors	inhibitor	NOUN
gs-4062	56	31	—	—	PUNCT
gs-4062	56	32	produced	produce	VERB
gs-4062	56	33	dramatic	dramatic	ADJ
gs-4062	56	34	and	and	CCONJ
gs-4062	56	35	sustained	sustained	ADJ
gs-4062	56	36	suppression	suppression	NOUN
gs-4062	56	37	of	of	ADP
gs-4062	56	38	viral	viral	ADJ
gs-4062	56	39	replication	replication	NOUN
gs-4062	56	40	.	.	PUNCT
gs-4062	57	1	mortality	mortality	NOUN
gs-4062	57	2	rates	rate	NOUN
gs-4062	57	3	plummeted	plummet	VERB
gs-4062	57	4	,	,	PUNCT
gs-4062	57	5	and	and	CCONJ
gs-4062	57	6	hospitals	hospital	NOUN
gs-4062	57	7	wards	ward	NOUN
gs-4062	57	8	that	that	PRON
gs-4062	57	9	were	be	AUX
gs-4062	57	10	once	once	ADV
gs-4062	57	11	filled	fill	VERB
gs-4062	57	12	with	with	ADP
gs-4062	57	13	dying	die	VERB
gs-4062	57	14	patients	patient	NOUN
gs-4062	57	15	began	begin	VERB
gs-4062	57	16	to	to	PART
gs-4062	57	17	empty	empty	VERB
gs-4062	57	18	.	.	PUNCT
gs-4062	58	1	yet	yet	ADV
gs-4062	58	2	,	,	PUNCT
gs-4062	58	3	this	this	DET
gs-4062	58	4	first	first	ADJ
gs-4062	58	5	generation	generation	NOUN
gs-4062	58	6	of	of	ADP
gs-4062	58	7	combination	combination	NOUN
gs-4062	58	8	therapy	therapy	NOUN
gs-4062	58	9	came	come	VERB
gs-4062	58	10	at	at	ADP
gs-4062	58	11	a	a	DET
gs-4062	58	12	steep	steep	ADJ
gs-4062	58	13	cost	cost	NOUN
gs-4062	58	14	.	.	PUNCT
gs-4062	59	1	regimens	regimen	NOUN
gs-4062	59	2	were	be	AUX
gs-4062	59	3	notoriously	notoriously	ADV
gs-4062	59	4	complex	complex	ADJ
gs-4062	59	5	,	,	PUNCT
gs-4062	59	6	involving	involve	VERB
gs-4062	59	7	dozens	dozen	NOUN
gs-4062	59	8	of	of	ADP
gs-4062	59	9	pills	pill	NOUN
gs-4062	59	10	taken	take	VERB
gs-4062	59	11	at	at	ADP
gs-4062	59	12	precise	precise	ADJ
gs-4062	59	13	times	time	NOUN
gs-4062	59	14	with	with	ADP
gs-4062	59	15	strict	strict	ADJ
gs-4062	59	16	dietary	dietary	ADJ
gs-4062	59	17	restrictions	restriction	NOUN
gs-4062	59	18	.	.	PUNCT
gs-4062	60	1	the	the	DET
gs-4062	60	2	toxicities	toxicity	NOUN
gs-4062	60	3	were	be	AUX
gs-4062	60	4	severe	severe	ADJ
gs-4062	60	5	and	and	CCONJ
gs-4062	60	6	often	often	ADV
gs-4062	60	7	debilitating	debilitate	VERB
gs-4062	60	8	:	:	PUNCT
gs-4062	60	9	peripheral	peripheral	ADJ
gs-4062	60	10	neuropathy	neuropathy	ADJ
gs-4062	60	11	,	,	PUNCT
gs-4062	60	12	pancreatic	pancreatic	ADJ
gs-4062	60	13	toxicity	toxicity	NOUN
gs-4062	60	14	,	,	PUNCT
gs-4062	60	15	severe	severe	ADJ
gs-4062	60	16	lipodystrophy	lipodystrophy	NOUN
gs-4062	60	17	(	(	PUNCT
gs-4062	60	18	redistribution	redistribution	NOUN
gs-4062	60	19	of	of	ADP
gs-4062	60	20	body	body	NOUN
gs-4062	60	21	fat	fat	NOUN
gs-4062	60	22	)	)	PUNCT
gs-4062	60	23	,	,	PUNCT
gs-4062	60	24	dyslipidemia	dyslipidemia	NOUN
gs-4062	60	25	,	,	PUNCT
gs-4062	60	26	and	and	CCONJ
gs-4062	60	27	georgian	georgian	PROPN
gs-4062	60	28	scientists/	scientists/	NUM
gs-4062	60	29	.	.	PUNCT
gs-4062	61	1	7	7	NUM
gs-4062	61	2	n	n	PRON
gs-4062	61	3	3	3	NUM
gs-4062	61	4	,	,	PUNCT
gs-4062	61	5	2025	2025	NUM
gs-4062	61	6	525	525	NUM
gs-4062	61	7	mitochondrial	mitochondrial	ADJ
gs-4062	61	8	damage	damage	NOUN
gs-4062	61	9	became	become	VERB
gs-4062	61	10	common	common	ADJ
gs-4062	61	11	features	feature	NOUN
gs-4062	61	12	of	of	ADP
gs-4062	61	13	long	long	ADJ
gs-4062	61	14	-	-	PUNCT
gs-4062	61	15	term	term	NOUN
gs-4062	61	16	survival	survival	NOUN
gs-4062	61	17	,	,	PUNCT
gs-4062	61	18	constant	constant	ADJ
gs-4062	61	19	reminders	reminder	NOUN
gs-4062	61	20	of	of	ADP
gs-4062	61	21	the	the	DET
gs-4062	61	22	disease	disease	NOUN
gs-4062	61	23	and	and	CCONJ
gs-4062	61	24	its	its	PRON
gs-4062	61	25	treatment	treatment	NOUN
gs-4062	61	26	.	.	PUNCT
gs-4062	62	1	the	the	DET
gs-4062	62	2	subsequent	subsequent	ADJ
gs-4062	62	3	years	year	NOUN
gs-4062	62	4	were	be	AUX
gs-4062	62	5	characterized	characterize	VERB
gs-4062	62	6	by	by	ADP
gs-4062	62	7	a	a	DET
gs-4062	62	8	process	process	NOUN
gs-4062	62	9	of	of	ADP
gs-4062	62	10	refinement	refinement	NOUN
gs-4062	62	11	and	and	CCONJ
gs-4062	62	12	simplification	simplification	NOUN
gs-4062	62	13	.	.	PUNCT
gs-4062	63	1	the	the	DET
gs-4062	63	2	goals	goal	NOUN
gs-4062	63	3	of	of	ADP
gs-4062	63	4	art	art	NOUN
gs-4062	63	5	expanded	expand	VERB
gs-4062	63	6	from	from	ADP
gs-4062	63	7	achieving	achieve	VERB
gs-4062	63	8	mere	mere	ADJ
gs-4062	63	9	survival	survival	NOUN
gs-4062	63	10	to	to	ADP
gs-4062	63	11	ensuring	ensure	VERB
gs-4062	63	12	a	a	DET
gs-4062	63	13	good	good	ADJ
gs-4062	63	14	quality	quality	NOUN
gs-4062	63	15	of	of	ADP
gs-4062	63	16	life	life	NOUN
gs-4062	63	17	.	.	PUNCT
gs-4062	64	1	the	the	DET
gs-4062	64	2	development	development	NOUN
gs-4062	64	3	of	of	ADP
gs-4062	64	4	fixed	fix	VERB
gs-4062	64	5	-	-	PUNCT
gs-4062	64	6	dose	dose	NOUN
gs-4062	64	7	combinations	combination	NOUN
gs-4062	64	8	(	(	PUNCT
gs-4062	64	9	fdcs	fdc	NOUN
gs-4062	64	10	)	)	PUNCT
gs-4062	64	11	consolidated	consolidate	VERB
gs-4062	64	12	multiple	multiple	ADJ
gs-4062	64	13	drugs	drug	NOUN
gs-4062	64	14	into	into	ADP
gs-4062	64	15	a	a	DET
gs-4062	64	16	single	single	ADJ
gs-4062	64	17	tablet	tablet	NOUN
gs-4062	64	18	,	,	PUNCT
gs-4062	64	19	drastically	drastically	ADV
gs-4062	64	20	reducing	reduce	VERB
gs-4062	64	21	pill	pill	NOUN
gs-4062	64	22	burden	burden	NOUN
gs-4062	64	23	.	.	PUNCT
gs-4062	65	1	the	the	DET
gs-4062	65	2	pharmacological	pharmacological	ADJ
gs-4062	65	3	classes	class	NOUN
gs-4062	65	4	diversified	diversify	VERB
gs-4062	65	5	with	with	ADP
gs-4062	65	6	the	the	DET
gs-4062	65	7	introduction	introduction	NOUN
gs-4062	65	8	of	of	ADP
gs-4062	65	9	entry	entry	NOUN
gs-4062	65	10	inhibitors	inhibitor	NOUN
gs-4062	65	11	,	,	PUNCT
gs-4062	65	12	integrase	integrase	NOUN
gs-4062	65	13	strand	strand	NOUN
gs-4062	65	14	transfer	transfer	NOUN
gs-4062	65	15	inhibitors	inhibitor	NOUN
gs-4062	65	16	(	(	PUNCT
gs-4062	65	17	instis	instis	NOUN
gs-4062	65	18	)	)	PUNCT
gs-4062	65	19	,	,	PUNCT
gs-4062	65	20	and	and	CCONJ
gs-4062	65	21	ccr5	ccr5	NOUN
gs-4062	65	22	antagonists	antagonist	NOUN
gs-4062	65	23	,	,	PUNCT
gs-4062	65	24	providing	provide	VERB
gs-4062	65	25	new	new	ADJ
gs-4062	65	26	mechanisms	mechanism	NOUN
gs-4062	65	27	to	to	PART
gs-4062	65	28	attack	attack	VERB
gs-4062	65	29	the	the	DET
gs-4062	65	30	virus	virus	NOUN
gs-4062	65	31	and	and	CCONJ
gs-4062	65	32	salvage	salvage	NOUN
gs-4062	65	33	treatment	treatment	NOUN
gs-4062	65	34	for	for	ADP
gs-4062	65	35	those	those	PRON
gs-4062	65	36	with	with	ADP
gs-4062	65	37	resistant	resistant	ADJ
gs-4062	65	38	virus	virus	NOUN
gs-4062	65	39	.	.	PUNCT
gs-4062	66	1	the	the	DET
gs-4062	66	2	toxic	toxic	ADJ
gs-4062	66	3	profile	profile	NOUN
gs-4062	66	4	of	of	ADP
gs-4062	66	5	drugs	drug	NOUN
gs-4062	66	6	improved	improve	VERB
gs-4062	66	7	significantly	significantly	ADV
gs-4062	66	8	;	;	PUNCT
gs-4062	66	9	tenofovir	tenofovir	NOUN
gs-4062	66	10	disoproxil	disoproxil	VERB
gs-4062	66	11	fumarate	fumarate	NOUN
gs-4062	66	12	(	(	PUNCT
gs-4062	66	13	tdf	tdf	NOUN
gs-4062	66	14	)	)	PUNCT
gs-4062	66	15	replaced	replace	VERB
gs-4062	66	16	older	old	ADJ
gs-4062	66	17	,	,	PUNCT
gs-4062	66	18	more	more	ADV
gs-4062	66	19	toxic	toxic	ADJ
gs-4062	66	20	nrtis	nrtis	NOUN
gs-4062	66	21	like	like	ADP
gs-4062	66	22	stavudine	stavudine	NOUN
gs-4062	66	23	and	and	CCONJ
gs-4062	66	24	zidovudine	zidovudine	NOUN
gs-4062	66	25	,	,	PUNCT
gs-4062	66	26	and	and	CCONJ
gs-4062	66	27	newer	new	ADJ
gs-4062	66	28	protease	protease	NOUN
gs-4062	66	29	inhibitors	inhibitor	NOUN
gs-4062	66	30	required	require	VERB
gs-4062	66	31	less	less	ADV
gs-4062	66	32	potent	potent	ADJ
gs-4062	66	33	boosting	boost	VERB
gs-4062	66	34	agents	agent	NOUN
gs-4062	66	35	.	.	PUNCT
gs-4062	67	1	the	the	DET
gs-4062	67	2	treatment	treatment	NOUN
gs-4062	67	3	paradigm	paradigm	NOUN
gs-4062	67	4	shifted	shift	VERB
gs-4062	67	5	towards	towards	ADP
gs-4062	67	6	earlier	early	ADJ
gs-4062	67	7	initiation	initiation	NOUN
gs-4062	67	8	of	of	ADP
gs-4062	67	9	therapy	therapy	NOUN
gs-4062	67	10	,	,	PUNCT
gs-4062	67	11	reinforced	reinforce	VERB
gs-4062	67	12	by	by	ADP
gs-4062	67	13	seminal	seminal	ADJ
gs-4062	67	14	studies	study	NOUN
gs-4062	67	15	like	like	ADP
gs-4062	67	16	start	start	VERB
gs-4062	67	17	and	and	CCONJ
gs-4062	67	18	temprano	temprano	VERB
gs-4062	67	19	,	,	PUNCT
gs-4062	67	20	which	which	PRON
gs-4062	67	21	demonstrated	demonstrate	VERB
gs-4062	67	22	that	that	SCONJ
gs-4062	67	23	immediate	immediate	ADJ
gs-4062	67	24	treatment	treatment	NOUN
gs-4062	67	25	upon	upon	SCONJ
gs-4062	67	26	diagnosis	diagnosis	NOUN
gs-4062	67	27	improved	improve	VERB
gs-4062	67	28	individual	individual	ADJ
gs-4062	67	29	health	health	NOUN
gs-4062	67	30	outcomes	outcome	NOUN
gs-4062	67	31	and	and	CCONJ
gs-4062	67	32	reduced	reduce	VERB
gs-4062	67	33	transmission	transmission	NOUN
gs-4062	67	34	risk	risk	NOUN
gs-4062	67	35	at	at	ADP
gs-4062	67	36	a	a	DET
gs-4062	67	37	population	population	NOUN
gs-4062	67	38	level	level	NOUN
gs-4062	67	39	.	.	PUNCT
gs-4062	68	1	this	this	DET
gs-4062	68	2	era	era	NOUN
gs-4062	68	3	established	establish	VERB
gs-4062	68	4	the	the	DET
gs-4062	68	5	principle	principle	NOUN
gs-4062	68	6	of	of	ADP
gs-4062	68	7	"	"	PUNCT
gs-4062	68	8	undetectable	undetectable	ADJ
gs-4062	68	9	=	=	SYM
gs-4062	68	10	untransmittable	untransmittable	ADJ
gs-4062	68	11	"	"	PUNCT
gs-4062	68	12	(	(	PUNCT
gs-4062	68	13	u	u	NOUN
gs-4062	68	14	=	=	NOUN
gs-4062	68	15	u	u	NOUN
gs-4062	68	16	)	)	PUNCT
gs-4062	68	17	,	,	PUNCT
gs-4062	68	18	a	a	DET
gs-4062	68	19	powerful	powerful	ADJ
gs-4062	68	20	concept	concept	NOUN
gs-4062	68	21	that	that	PRON
gs-4062	68	22	dismantles	dismantle	VERB
gs-4062	68	23	stigma	stigma	NOUN
gs-4062	68	24	and	and	CCONJ
gs-4062	68	25	recasts	recast	VERB
gs-4062	68	26	art	art	NOUN
gs-4062	68	27	as	as	ADP
gs-4062	68	28	a	a	DET
gs-4062	68	29	primary	primary	ADJ
gs-4062	68	30	tool	tool	NOUN
gs-4062	68	31	for	for	ADP
gs-4062	68	32	hiv	hiv	PROPN
gs-4062	68	33	prevention	prevention	NOUN
gs-4062	68	34	.	.	PUNCT
gs-4062	69	1	despite	despite	SCONJ
gs-4062	69	2	these	these	DET
gs-4062	69	3	remarkable	remarkable	ADJ
gs-4062	69	4	strides	stride	NOUN
gs-4062	69	5	,	,	PUNCT
gs-4062	69	6	significant	significant	ADJ
gs-4062	69	7	challenges	challenge	NOUN
gs-4062	69	8	persisted	persist	VERB
gs-4062	69	9	.	.	PUNCT
gs-4062	70	1	adherence	adherence	NOUN
gs-4062	70	2	to	to	ADP
gs-4062	70	3	daily	daily	ADJ
gs-4062	70	4	oral	oral	ADJ
gs-4062	70	5	therapy	therapy	NOUN
gs-4062	70	6	remains	remain	VERB
gs-4062	70	7	a	a	DET
gs-4062	70	8	barrier	barrier	NOUN
gs-4062	70	9	for	for	ADP
gs-4062	70	10	some	some	PRON
gs-4062	70	11	,	,	PUNCT
gs-4062	70	12	leading	lead	VERB
gs-4062	70	13	to	to	ADP
gs-4062	70	14	virological	virological	ADJ
gs-4062	70	15	failure	failure	NOUN
gs-4062	70	16	and	and	CCONJ
gs-4062	70	17	the	the	DET
gs-4062	70	18	potential	potential	ADJ
gs-4062	70	19	development	development	NOUN
gs-4062	70	20	of	of	ADP
gs-4062	70	21	resistance	resistance	NOUN
gs-4062	70	22	.	.	PUNCT
gs-4062	71	1	long	long	ADJ
gs-4062	71	2	-	-	PUNCT
gs-4062	71	3	term	term	NOUN
gs-4062	71	4	toxicities	toxicity	NOUN
gs-4062	71	5	,	,	PUNCT
gs-4062	71	6	though	though	SCONJ
gs-4062	71	7	less	less	ADV
gs-4062	71	8	severe	severe	ADJ
gs-4062	71	9	,	,	PUNCT
gs-4062	71	10	continued	continue	VERB
gs-4062	71	11	to	to	PART
gs-4062	71	12	pose	pose	VERB
gs-4062	71	13	risks	risk	NOUN
gs-4062	71	14	for	for	ADP
gs-4062	71	15	an	an	DET
gs-4062	71	16	aging	age	VERB
gs-4062	71	17	population	population	NOUN
gs-4062	71	18	of	of	ADP
gs-4062	71	19	people	people	NOUN
gs-4062	71	20	living	live	VERB
gs-4062	71	21	with	with	ADP
gs-4062	71	22	hiv	hiv	PROPN
gs-4062	71	23	,	,	PUNCT
gs-4062	71	24	including	include	VERB
gs-4062	71	25	cardiovascular	cardiovascular	ADJ
gs-4062	71	26	,	,	PUNCT
gs-4062	71	27	renal	renal	ADJ
gs-4062	71	28	,	,	PUNCT
gs-4062	71	29	and	and	CCONJ
gs-4062	71	30	bone	bone	NOUN
gs-4062	71	31	diseases	disease	NOUN
gs-4062	71	32	.	.	PUNCT
gs-4062	72	1	furthermore	furthermore	ADV
gs-4062	72	2	,	,	PUNCT
gs-4062	72	3	the	the	DET
gs-4062	72	4	specter	specter	NOUN
gs-4062	72	5	of	of	ADP
gs-4062	72	6	stigma	stigma	NOUN
gs-4062	72	7	,	,	PUNCT
gs-4062	72	8	though	though	SCONJ
gs-4062	72	9	challenged	challenge	VERB
gs-4062	72	10	by	by	ADP
gs-4062	72	11	u	u	NOUN
gs-4062	72	12	=	=	NOUN
gs-4062	72	13	u	u	NOUN
gs-4062	72	14	,	,	PUNCT
gs-4062	72	15	remained	remained	AUX
gs-4062	72	16	intertwined	intertwine	VERB
gs-4062	72	17	with	with	ADP
gs-4062	72	18	the	the	DET
gs-4062	72	19	daily	daily	ADJ
gs-4062	72	20	act	act	NOUN
gs-4062	72	21	of	of	ADP
gs-4062	72	22	taking	take	VERB
gs-4062	72	23	hiv	hiv	PROPN
gs-4062	72	24	medication	medication	NOUN
gs-4062	72	25	.	.	PUNCT
gs-4062	73	1	for	for	ADP
gs-4062	73	2	the	the	DET
gs-4062	73	3	heavily	heavily	ADV
gs-4062	73	4	treatment	treatment	NOUN
gs-4062	73	5	-	-	PUNCT
gs-4062	73	6	experienced	experience	VERB
gs-4062	73	7	population	population	NOUN
gs-4062	73	8	with	with	ADP
gs-4062	73	9	multidrug	multidrug	NOUN
gs-4062	73	10	-	-	PUNCT
gs-4062	73	11	resistant	resistant	ADJ
gs-4062	73	12	virus	virus	NOUN
gs-4062	73	13	,	,	PUNCT
gs-4062	73	14	therapeutic	therapeutic	ADJ
gs-4062	73	15	options	option	NOUN
gs-4062	73	16	became	become	VERB
gs-4062	73	17	increasingly	increasingly	ADV
gs-4062	73	18	limited	limited	ADJ
gs-4062	73	19	and	and	CCONJ
gs-4062	73	20	complex	complex	ADJ
gs-4062	73	21	.	.	PUNCT
gs-4062	74	1	it	it	PRON
gs-4062	74	2	is	be	AUX
gs-4062	74	3	within	within	ADP
gs-4062	74	4	this	this	DET
gs-4062	74	5	context	context	NOUN
gs-4062	74	6	that	that	SCONJ
gs-4062	74	7	the	the	DET
gs-4062	74	8	latest	late	ADJ
gs-4062	74	9	revolution	revolution	NOUN
gs-4062	74	10	in	in	ADP
gs-4062	74	11	antiretroviral	antiretroviral	ADJ
gs-4062	74	12	therapy	therapy	NOUN
gs-4062	74	13	is	be	AUX
gs-4062	74	14	unfolding	unfold	VERB
gs-4062	74	15	—	—	PUNCT
gs-4062	74	16	a	a	DET
gs-4062	74	17	revolution	revolution	NOUN
gs-4062	74	18	driven	drive	VERB
gs-4062	74	19	not	not	PART
gs-4062	74	20	by	by	ADP
gs-4062	74	21	incremental	incremental	ADJ
gs-4062	74	22	change	change	NOUN
gs-4062	74	23	,	,	PUNCT
gs-4062	74	24	but	but	CCONJ
gs-4062	74	25	by	by	ADP
gs-4062	74	26	fundamental	fundamental	ADJ
gs-4062	74	27	leaps	leap	NOUN
gs-4062	74	28	in	in	ADP
gs-4062	74	29	drug	drug	NOUN
gs-4062	74	30	design	design	NOUN
gs-4062	74	31	,	,	PUNCT
gs-4062	74	32	delivery	delivery	NOUN
gs-4062	74	33	,	,	PUNCT
gs-4062	74	34	and	and	CCONJ
gs-4062	74	35	mechanism	mechanism	NOUN
gs-4062	74	36	of	of	ADP
gs-4062	74	37	action	action	NOUN
gs-4062	74	38	.	.	PUNCT
gs-4062	75	1	the	the	DET
gs-4062	75	2	newest	new	ADJ
gs-4062	75	3	generation	generation	NOUN
gs-4062	75	4	of	of	ADP
gs-4062	75	5	antiretroviral	antiretroviral	ADJ
gs-4062	75	6	medicines	medicine	NOUN
gs-4062	75	7	is	be	AUX
gs-4062	75	8	characterized	characterize	VERB
gs-4062	75	9	by	by	ADP
gs-4062	75	10	several	several	ADJ
gs-4062	75	11	defining	define	VERB
gs-4062	75	12	features	feature	NOUN
gs-4062	75	13	that	that	PRON
gs-4062	75	14	collectively	collectively	ADV
gs-4062	75	15	address	address	VERB
gs-4062	75	16	the	the	DET
gs-4062	75	17	lingering	linger	VERB
gs-4062	75	18	limitations	limitation	NOUN
gs-4062	75	19	of	of	ADP
gs-4062	75	20	previous	previous	ADJ
gs-4062	75	21	regimens	regimen	NOUN
gs-4062	75	22	.	.	PUNCT
gs-4062	76	1	first	first	ADV
gs-4062	76	2	is	be	AUX
gs-4062	76	3	the	the	DET
gs-4062	76	4	pursuit	pursuit	NOUN
gs-4062	76	5	of	of	ADP
gs-4062	76	6	unprecedented	unprecedented	ADJ
gs-4062	76	7	potency	potency	NOUN
gs-4062	76	8	and	and	CCONJ
gs-4062	76	9	a	a	DET
gs-4062	76	10	high	high	ADJ
gs-4062	76	11	genetic	genetic	ADJ
gs-4062	76	12	barrier	barrier	NOUN
gs-4062	76	13	to	to	ADP
gs-4062	76	14	resistance	resistance	NOUN
gs-4062	76	15	.	.	PUNCT
gs-4062	77	1	second	second	ADJ
gs-4062	77	2	-	-	PUNCT
gs-4062	77	3	generation	generation	NOUN
gs-4062	77	4	instis	instis	NOUN
gs-4062	77	5	,	,	PUNCT
gs-4062	77	6	such	such	ADJ
gs-4062	77	7	as	as	ADP
gs-4062	77	8	dolutegravir	dolutegravir	NOUN
gs-4062	77	9	and	and	CCONJ
gs-4062	77	10	bictegravir	bictegravir	PROPN
gs-4062	77	11	,	,	PUNCT
gs-4062	77	12	bind	bind	VERB
gs-4062	77	13	more	more	ADV
gs-4062	77	14	tightly	tightly	ADV
gs-4062	77	15	to	to	ADP
gs-4062	77	16	their	their	PRON
gs-4062	77	17	target	target	NOUN
gs-4062	77	18	and	and	CCONJ
gs-4062	77	19	require	require	VERB
gs-4062	77	20	multiple	multiple	ADJ
gs-4062	77	21	mutations	mutation	NOUN
gs-4062	77	22	for	for	ADP
gs-4062	77	23	the	the	DET
gs-4062	77	24	virus	virus	NOUN
gs-4062	77	25	to	to	PART
gs-4062	77	26	develop	develop	VERB
gs-4062	77	27	resistance	resistance	NOUN
gs-4062	77	28	,	,	PUNCT
gs-4062	77	29	making	make	VERB
gs-4062	77	30	virological	virological	ADJ
gs-4062	77	31	failure	failure	NOUN
gs-4062	77	32	a	a	DET
gs-4062	77	33	rare	rare	ADJ
gs-4062	77	34	event	event	NOUN
gs-4062	77	35	.	.	PUNCT
gs-4062	78	1	this	this	DET
gs-4062	78	2	robustness	robustness	NOUN
gs-4062	78	3	offers	offer	VERB
gs-4062	78	4	a	a	DET
gs-4062	78	5	more	more	ADV
gs-4062	78	6	forgiving	forgiving	ADJ
gs-4062	78	7	platform	platform	NOUN
gs-4062	78	8	for	for	ADP
gs-4062	78	9	treatment	treatment	NOUN
gs-4062	78	10	,	,	PUNCT
gs-4062	78	11	enhancing	enhance	VERB
gs-4062	78	12	its	its	PRON
gs-4062	78	13	durability	durability	NOUN
gs-4062	78	14	.	.	PUNCT
gs-4062	79	1	second	second	ADJ
gs-4062	79	2	is	be	AUX
gs-4062	79	3	the	the	DET
gs-4062	79	4	optimization	optimization	NOUN
gs-4062	79	5	of	of	ADP
gs-4062	79	6	safety	safety	NOUN
gs-4062	79	7	and	and	CCONJ
gs-4062	79	8	tolerability	tolerability	NOUN
gs-4062	79	9	profiles	profile	NOUN
gs-4062	79	10	.	.	PUNCT
gs-4062	80	1	the	the	DET
gs-4062	80	2	development	development	NOUN
gs-4062	80	3	of	of	ADP
gs-4062	80	4	tenofovir	tenofovir	PROPN
gs-4062	80	5	alafenamide	alafenamide	PROPN
gs-4062	80	6	(	(	PUNCT
gs-4062	80	7	taf	taf	PROPN
gs-4062	80	8	)	)	PUNCT
gs-4062	80	9	,	,	PUNCT
gs-4062	80	10	a	a	DET
gs-4062	80	11	prodrug	prodrug	NOUN
gs-4062	80	12	of	of	ADP
gs-4062	80	13	tenofovir	tenofovir	NOUN
gs-4062	80	14	,	,	PUNCT
gs-4062	80	15	delivers	deliver	VERB
gs-4062	80	16	effective	effective	ADJ
gs-4062	80	17	antiviral	antiviral	ADJ
gs-4062	80	18	activity	activity	NOUN
gs-4062	80	19	while	while	SCONJ
gs-4062	80	20	significantly	significantly	ADV
gs-4062	80	21	reducing	reduce	VERB
gs-4062	80	22	exposure	exposure	NOUN
gs-4062	80	23	in	in	ADP
gs-4062	80	24	the	the	DET
gs-4062	80	25	kidneys	kidney	NOUN
gs-4062	80	26	and	and	CCONJ
gs-4062	80	27	bones	bone	NOUN
gs-4062	80	28	,	,	PUNCT
gs-4062	80	29	thereby	thereby	ADV
gs-4062	80	30	mitigating	mitigate	VERB
gs-4062	80	31	the	the	DET
gs-4062	80	32	risks	risk	NOUN
gs-4062	80	33	of	of	ADP
gs-4062	80	34	renal	renal	ADJ
gs-4062	80	35	impairment	impairment	NOUN
gs-4062	80	36	and	and	CCONJ
gs-4062	80	37	osteoporosis	osteoporosis	NOUN
gs-4062	80	38	that	that	PRON
gs-4062	80	39	were	be	AUX
gs-4062	80	40	associated	associate	VERB
gs-4062	80	41	with	with	ADP
gs-4062	80	42	tdf	tdf	PROPN
gs-4062	80	43	.	.	PUNCT
gs-4062	81	1	this	this	DET
gs-4062	81	2	focus	focus	NOUN
gs-4062	81	3	on	on	ADP
gs-4062	81	4	long	long	ADJ
gs-4062	81	5	-	-	PUNCT
gs-4062	81	6	term	term	NOUN
gs-4062	81	7	organ	organ	NOUN
gs-4062	81	8	health	health	NOUN
gs-4062	81	9	is	be	AUX
gs-4062	81	10	critical	critical	ADJ
gs-4062	81	11	for	for	ADP
gs-4062	81	12	managing	manage	VERB
gs-4062	81	13	hiv	hiv	PROPN
gs-4062	81	14	as	as	ADP
gs-4062	81	15	a	a	DET
gs-4062	81	16	chronic	chronic	ADJ
gs-4062	81	17	condition	condition	NOUN
gs-4062	81	18	over	over	ADP
gs-4062	81	19	a	a	DET
gs-4062	81	20	lifetime	lifetime	NOUN
gs-4062	81	21	.	.	PUNCT
gs-4062	82	1	perhaps	perhaps	ADV
gs-4062	82	2	the	the	DET
gs-4062	82	3	most	most	ADJ
gs-4062	82	4	paradigm	paradigm	NOUN
gs-4062	82	5	-	-	PUNCT
gs-4062	82	6	shifting	shift	VERB
gs-4062	82	7	advancement	advancement	NOUN
gs-4062	82	8	is	be	AUX
gs-4062	82	9	the	the	DET
gs-4062	82	10	move	move	NOUN
gs-4062	82	11	towards	towards	ADP
gs-4062	82	12	long	long	ADV
gs-4062	82	13	-	-	PUNCT
gs-4062	82	14	acting	act	VERB
gs-4062	82	15	formulations	formulation	NOUN
gs-4062	82	16	.	.	PUNCT
gs-4062	83	1	the	the	DET
gs-4062	83	2	successful	successful	ADJ
gs-4062	83	3	development	development	NOUN
gs-4062	83	4	and	and	CCONJ
gs-4062	83	5	approval	approval	NOUN
gs-4062	83	6	of	of	ADP
gs-4062	83	7	long	long	ADV
gs-4062	83	8	-	-	PUNCT
gs-4062	83	9	acting	act	VERB
gs-4062	83	10	injectable	injectable	ADJ
gs-4062	83	11	cabotegravir	cabotegravir	NOUN
gs-4062	83	12	and	and	CCONJ
gs-4062	83	13	rilpivirine	rilpivirine	VERB
gs-4062	83	14	,	,	PUNCT
gs-4062	83	15	administered	administer	VERB
gs-4062	83	16	every	every	DET
gs-4062	83	17	one	one	NUM
gs-4062	83	18	or	or	CCONJ
gs-4062	83	19	two	two	NUM
gs-4062	83	20	months	month	NOUN
gs-4062	83	21	,	,	PUNCT
gs-4062	83	22	represents	represent	VERB
gs-4062	83	23	a	a	DET
gs-4062	83	24	quantum	quantum	ADJ
gs-4062	83	25	leap	leap	NOUN
gs-4062	83	26	in	in	ADP
gs-4062	83	27	treatment	treatment	NOUN
gs-4062	83	28	modality	modality	NOUN
gs-4062	83	29	.	.	PUNCT
gs-4062	84	1	this	this	DET
gs-4062	84	2	approach	approach	NOUN
gs-4062	84	3	fundamentally	fundamentally	ADV
gs-4062	84	4	decouples	decouple	VERB
gs-4062	84	5	hiv	hiv	PROPN
gs-4062	84	6	management	management	NOUN
gs-4062	84	7	from	from	ADP
gs-4062	84	8	daily	daily	ADJ
gs-4062	84	9	pill	pill	NOUN
gs-4062	84	10	-	-	PUNCT
gs-4062	84	11	taking	taking	NOUN
gs-4062	84	12	,	,	PUNCT
gs-4062	84	13	addressing	address	VERB
gs-4062	84	14	issues	issue	NOUN
gs-4062	84	15	of	of	ADP
gs-4062	84	16	adherence	adherence	NOUN
gs-4062	84	17	,	,	PUNCT
gs-4062	84	18	stigma	stigma	NOUN
gs-4062	84	19	,	,	PUNCT
gs-4062	84	20	and	and	CCONJ
gs-4062	84	21	quality	quality	NOUN
gs-4062	84	22	of	of	ADP
gs-4062	84	23	life	life	NOUN
gs-4062	84	24	in	in	ADP
gs-4062	84	25	a	a	DET
gs-4062	84	26	way	way	NOUN
gs-4062	84	27	that	that	PRON
gs-4062	84	28	was	be	AUX
gs-4062	84	29	previously	previously	ADV
gs-4062	84	30	unimaginable	unimaginable	ADJ
gs-4062	84	31	.	.	PUNCT
gs-4062	85	1	concurrently	concurrently	ADV
gs-4062	85	2	,	,	PUNCT
gs-4062	85	3	the	the	DET
gs-4062	85	4	frontier	frontier	NOUN
gs-4062	85	5	of	of	ADP
gs-4062	85	6	drug	drug	NOUN
gs-4062	85	7	discovery	discovery	PROPN
gs-4062	85	8	has	have	AUX
gs-4062	85	9	expanded	expand	VERB
gs-4062	85	10	to	to	PART
gs-4062	85	11	include	include	VERB
gs-4062	85	12	entirely	entirely	ADV
gs-4062	85	13	novel	novel	ADJ
gs-4062	85	14	mechanisms	mechanism	NOUN
gs-4062	85	15	of	of	ADP
gs-4062	85	16	action	action	NOUN
gs-4062	85	17	that	that	PRON
gs-4062	85	18	attack	attack	VERB
gs-4062	85	19	the	the	DET
gs-4062	85	20	virus	virus	NOUN
gs-4062	85	21	at	at	ADP
gs-4062	85	22	new	new	ADJ
gs-4062	85	23	vulnerabilities	vulnerability	NOUN
gs-4062	85	24	.	.	PUNCT
gs-4062	86	1	capsid	capsid	ADJ
gs-4062	86	2	inhibitors	inhibitor	NOUN
gs-4062	86	3	,	,	PUNCT
gs-4062	86	4	such	such	ADJ
gs-4062	86	5	as	as	ADP
gs-4062	86	6	lenacapavir	lenacapavir	NOUN
gs-4062	86	7	,	,	PUNCT
gs-4062	86	8	disrupt	disrupt	VERB
gs-4062	86	9	the	the	DET
gs-4062	86	10	virus	virus	NOUN
gs-4062	86	11	's	's	PART
gs-4062	86	12	protective	protective	ADJ
gs-4062	86	13	shell	shell	NOUN
gs-4062	86	14	at	at	ADP
gs-4062	86	15	multiple	multiple	ADJ
gs-4062	86	16	stages	stage	NOUN
gs-4062	86	17	of	of	ADP
gs-4062	86	18	its	its	PRON
gs-4062	86	19	life	life	NOUN
gs-4062	86	20	cycle	cycle	NOUN
gs-4062	86	21	,	,	PUNCT
gs-4062	86	22	offering	offer	VERB
gs-4062	86	23	a	a	DET
gs-4062	86	24	powerful	powerful	ADJ
gs-4062	86	25	new	new	ADJ
gs-4062	86	26	option	option	NOUN
gs-4062	86	27	for	for	ADP
gs-4062	86	28	patients	patient	NOUN
gs-4062	86	29	georgian	georgian	VERB
gs-4062	86	30	scientists/	scientists/	NUM
gs-4062	86	31	.	.	PUNCT
gs-4062	87	1	7	7	NUM
gs-4062	87	2	n	n	PRON
gs-4062	87	3	3	3	NUM
gs-4062	87	4	,	,	PUNCT
gs-4062	87	5	2025	2025	NUM
gs-4062	87	6	526	526	NUM
gs-4062	87	7	with	with	ADP
gs-4062	87	8	extensive	extensive	ADJ
gs-4062	87	9	drug	drug	NOUN
gs-4062	87	10	resistance	resistance	NOUN
gs-4062	87	11	.	.	PUNCT
gs-4062	88	1	furthermore	furthermore	ADV
gs-4062	88	2	,	,	PUNCT
gs-4062	88	3	the	the	DET
gs-4062	88	4	exploration	exploration	NOUN
gs-4062	88	5	of	of	ADP
gs-4062	88	6	broadly	broadly	ADV
gs-4062	88	7	neutralizing	neutralize	VERB
gs-4062	88	8	antibodies	antibody	NOUN
gs-4062	88	9	(	(	PUNCT
gs-4062	88	10	bnabs	bnab	NOUN
gs-4062	88	11	)	)	PUNCT
gs-4062	88	12	and	and	CCONJ
gs-4062	88	13	immune	immune	NOUN
gs-4062	88	14	-	-	PUNCT
gs-4062	88	15	based	base	VERB
gs-4062	88	16	therapies	therapy	NOUN
gs-4062	88	17	opens	open	VERB
gs-4062	88	18	new	new	ADJ
gs-4062	88	19	avenues	avenue	NOUN
gs-4062	88	20	not	not	PART
gs-4062	88	21	just	just	ADV
gs-4062	88	22	for	for	ADP
gs-4062	88	23	treatment	treatment	NOUN
gs-4062	88	24	,	,	PUNCT
gs-4062	88	25	but	but	CCONJ
gs-4062	88	26	for	for	ADP
gs-4062	88	27	potential	potential	ADJ
gs-4062	88	28	strategies	strategy	NOUN
gs-4062	88	29	aimed	aim	VERB
gs-4062	88	30	at	at	ADP
gs-4062	88	31	long	long	ADJ
gs-4062	88	32	-	-	PUNCT
gs-4062	88	33	term	term	NOUN
gs-4062	88	34	remission	remission	NOUN
gs-4062	88	35	or	or	CCONJ
gs-4062	88	36	a	a	DET
gs-4062	88	37	functional	functional	ADJ
gs-4062	88	38	cure	cure	NOUN
gs-4062	88	39	.	.	PUNCT
gs-4062	89	1	however	however	ADV
gs-4062	89	2	,	,	PUNCT
gs-4062	89	3	the	the	DET
gs-4062	89	4	introduction	introduction	NOUN
gs-4062	89	5	of	of	ADP
gs-4062	89	6	these	these	DET
gs-4062	89	7	groundbreaking	groundbreake	VERB
gs-4062	89	8	technologies	technology	NOUN
gs-4062	89	9	occurs	occur	VERB
gs-4062	89	10	against	against	ADP
gs-4062	89	11	a	a	DET
gs-4062	89	12	backdrop	backdrop	NOUN
gs-4062	89	13	of	of	ADP
gs-4062	89	14	profound	profound	ADJ
gs-4062	89	15	and	and	CCONJ
gs-4062	89	16	persistent	persistent	ADJ
gs-4062	89	17	global	global	ADJ
gs-4062	89	18	inequity	inequity	NOUN
gs-4062	89	19	.	.	PUNCT
gs-4062	90	1	the	the	DET
gs-4062	90	2	brilliant	brilliant	ADJ
gs-4062	90	3	promise	promise	NOUN
gs-4062	90	4	of	of	ADP
gs-4062	90	5	long	long	ADV
gs-4062	90	6	-	-	PUNCT
gs-4062	90	7	acting	act	VERB
gs-4062	90	8	injectables	injectable	NOUN
gs-4062	90	9	and	and	CCONJ
gs-4062	90	10	novel	novel	ADJ
gs-4062	90	11	agents	agent	NOUN
gs-4062	90	12	stands	stand	VERB
gs-4062	90	13	in	in	ADP
gs-4062	90	14	stark	stark	ADJ
gs-4062	90	15	contrast	contrast	NOUN
gs-4062	90	16	to	to	ADP
gs-4062	90	17	the	the	DET
gs-4062	90	18	reality	reality	NOUN
gs-4062	90	19	in	in	ADP
gs-4062	90	20	many	many	ADJ
gs-4062	90	21	lowand	lowand	ADJ
gs-4062	90	22	middle	middle	ADJ
gs-4062	90	23	-	-	PUNCT
gs-4062	90	24	income	income	NOUN
gs-4062	90	25	countries	country	NOUN
gs-4062	90	26	(	(	PUNCT
gs-4062	90	27	lmics	lmic	NOUN
gs-4062	90	28	)	)	PUNCT
gs-4062	90	29	,	,	PUNCT
gs-4062	90	30	where	where	SCONJ
gs-4062	90	31	health	health	NOUN
gs-4062	90	32	systems	system	NOUN
gs-4062	90	33	still	still	ADV
gs-4062	90	34	struggle	struggle	VERB
gs-4062	90	35	to	to	PART
gs-4062	90	36	provide	provide	VERB
gs-4062	90	37	consistent	consistent	ADJ
gs-4062	90	38	access	access	NOUN
gs-4062	90	39	to	to	ADP
gs-4062	90	40	even	even	ADV
gs-4062	90	41	the	the	DET
gs-4062	90	42	most	most	ADV
gs-4062	90	43	basic	basic	ADJ
gs-4062	90	44	oral	oral	ADJ
gs-4062	90	45	regimens	regimen	NOUN
gs-4062	90	46	.	.	PUNCT
gs-4062	91	1	the	the	DET
gs-4062	91	2	challenges	challenge	NOUN
gs-4062	91	3	of	of	ADP
gs-4062	91	4	cost	cost	NOUN
gs-4062	91	5	,	,	PUNCT
gs-4062	91	6	cold	cold	ADJ
gs-4062	91	7	-	-	PUNCT
gs-4062	91	8	chain	chain	NOUN
gs-4062	91	9	storage	storage	NOUN
gs-4062	91	10	,	,	PUNCT
gs-4062	91	11	healthcare	healthcare	NOUN
gs-4062	91	12	infrastructure	infrastructure	NOUN
gs-4062	91	13	,	,	PUNCT
gs-4062	91	14	and	and	CCONJ
gs-4062	91	15	training	training	NOUN
gs-4062	91	16	present	present	ADJ
gs-4062	91	17	formidable	formidable	ADJ
gs-4062	91	18	barriers	barrier	NOUN
gs-4062	91	19	to	to	ADP
gs-4062	91	20	the	the	DET
gs-4062	91	21	equitable	equitable	ADJ
gs-4062	91	22	global	global	ADJ
gs-4062	91	23	rollout	rollout	NOUN
gs-4062	91	24	of	of	ADP
gs-4062	91	25	these	these	DET
gs-4062	91	26	advanced	advanced	ADJ
gs-4062	91	27	therapies	therapy	NOUN
gs-4062	91	28	.	.	PUNCT
gs-4062	92	1	this	this	DET
gs-4062	92	2	disparity	disparity	NOUN
gs-4062	92	3	risks	risk	NOUN
gs-4062	92	4	creating	create	VERB
gs-4062	92	5	a	a	DET
gs-4062	92	6	two	two	NUM
gs-4062	92	7	-	-	PUNCT
gs-4062	92	8	tiered	tiere	VERB
gs-4062	92	9	system	system	NOUN
gs-4062	92	10	of	of	ADP
gs-4062	92	11	hiv	hiv	PROPN
gs-4062	92	12	care	care	NOUN
gs-4062	92	13	:	:	PUNCT
gs-4062	92	14	one	one	NUM
gs-4062	92	15	for	for	ADP
gs-4062	92	16	the	the	DET
gs-4062	92	17	wealthy	wealthy	ADJ
gs-4062	92	18	with	with	ADP
gs-4062	92	19	access	access	NOUN
gs-4062	92	20	to	to	ADP
gs-4062	92	21	the	the	DET
gs-4062	92	22	most	most	ADV
gs-4062	92	23	modern	modern	ADJ
gs-4062	92	24	,	,	PUNCT
gs-4062	92	25	convenient	convenient	ADJ
gs-4062	92	26	treatments	treatment	NOUN
gs-4062	92	27	,	,	PUNCT
gs-4062	92	28	and	and	CCONJ
gs-4062	92	29	another	another	PRON
gs-4062	92	30	for	for	ADP
gs-4062	92	31	the	the	DET
gs-4062	92	32	poor	poor	ADJ
gs-4062	92	33	,	,	PUNCT
gs-4062	92	34	reliant	reliant	ADJ
gs-4062	92	35	on	on	ADP
gs-4062	92	36	older	old	ADJ
gs-4062	92	37	technologies	technology	NOUN
gs-4062	92	38	.	.	PUNCT
gs-4062	93	1	furthermore	furthermore	ADV
gs-4062	93	2	,	,	PUNCT
gs-4062	93	3	these	these	DET
gs-4062	93	4	new	new	ADJ
gs-4062	93	5	therapies	therapy	NOUN
gs-4062	93	6	bring	bring	VERB
gs-4062	93	7	their	their	PRON
gs-4062	93	8	own	own	ADJ
gs-4062	93	9	unique	unique	ADJ
gs-4062	93	10	challenges	challenge	NOUN
gs-4062	93	11	,	,	PUNCT
gs-4062	93	12	such	such	ADJ
gs-4062	93	13	as	as	ADP
gs-4062	93	14	the	the	DET
gs-4062	93	15	management	management	NOUN
gs-4062	93	16	of	of	ADP
gs-4062	93	17	novel	novel	ADJ
gs-4062	93	18	side	side	NOUN
gs-4062	93	19	effects	effect	NOUN
gs-4062	93	20	like	like	ADP
gs-4062	93	21	weight	weight	NOUN
gs-4062	93	22	gain	gain	NOUN
gs-4062	93	23	associated	associate	VERB
gs-4062	93	24	with	with	ADP
gs-4062	93	25	instis	instis	PROPN
gs-4062	93	26	and	and	CCONJ
gs-4062	93	27	the	the	DET
gs-4062	93	28	logistical	logistical	ADJ
gs-4062	93	29	complexities	complexity	NOUN
gs-4062	93	30	of	of	ADP
gs-4062	93	31	managing	manage	VERB
gs-4062	93	32	the	the	DET
gs-4062	93	33	long	long	ADJ
gs-4062	93	34	"	"	PUNCT
gs-4062	93	35	tail	tail	NOUN
gs-4062	93	36	"	"	PUNCT
gs-4062	93	37	of	of	ADP
gs-4062	93	38	drug	drug	NOUN
gs-4062	93	39	activity	activity	NOUN
gs-4062	93	40	after	after	SCONJ
gs-4062	93	41	an	an	DET
gs-4062	93	42	injection	injection	NOUN
gs-4062	93	43	is	be	AUX
gs-4062	93	44	administered	administer	VERB
gs-4062	93	45	,	,	PUNCT
gs-4062	93	46	which	which	PRON
gs-4062	93	47	can	can	AUX
gs-4062	93	48	foster	foster	VERB
gs-4062	93	49	resistance	resistance	NOUN
gs-4062	93	50	if	if	SCONJ
gs-4062	93	51	a	a	DET
gs-4062	93	52	patient	patient	NOUN
gs-4062	93	53	is	be	AUX
gs-4062	93	54	lost	lose	VERB
gs-4062	93	55	to	to	PART
gs-4062	93	56	follow	follow	VERB
gs-4062	93	57	-	-	PUNCT
gs-4062	93	58	up	up	NOUN
gs-4062	93	59	.	.	PUNCT
gs-4062	94	1	this	this	DET
gs-4062	94	2	paper	paper	NOUN
gs-4062	94	3	will	will	AUX
gs-4062	94	4	provide	provide	VERB
gs-4062	94	5	a	a	DET
gs-4062	94	6	comprehensive	comprehensive	ADJ
gs-4062	94	7	examination	examination	NOUN
gs-4062	94	8	of	of	ADP
gs-4062	94	9	this	this	DET
gs-4062	94	10	new	new	ADJ
gs-4062	94	11	era	era	NOUN
gs-4062	94	12	in	in	ADP
gs-4062	94	13	antiretroviral	antiretroviral	ADJ
gs-4062	94	14	therapy	therapy	NOUN
gs-4062	94	15	.	.	PUNCT
gs-4062	95	1	it	it	PRON
gs-4062	95	2	will	will	AUX
gs-4062	95	3	delve	delve	VERB
gs-4062	95	4	into	into	ADP
gs-4062	95	5	the	the	DET
gs-4062	95	6	detailed	detailed	ADJ
gs-4062	95	7	classification	classification	NOUN
gs-4062	95	8	and	and	CCONJ
gs-4062	95	9	sophisticated	sophisticated	ADJ
gs-4062	95	10	mechanisms	mechanism	NOUN
gs-4062	95	11	of	of	ADP
gs-4062	95	12	action	action	NOUN
gs-4062	95	13	that	that	PRON
gs-4062	95	14	define	define	VERB
gs-4062	95	15	these	these	DET
gs-4062	95	16	novel	novel	ADJ
gs-4062	95	17	agents	agent	NOUN
gs-4062	95	18	,	,	PUNCT
gs-4062	95	19	explaining	explain	VERB
gs-4062	95	20	how	how	SCONJ
gs-4062	95	21	their	their	PRON
gs-4062	95	22	unique	unique	ADJ
gs-4062	95	23	pharmacological	pharmacological	ADJ
gs-4062	95	24	properties	property	NOUN
gs-4062	95	25	translate	translate	VERB
gs-4062	95	26	into	into	ADP
gs-4062	95	27	clinical	clinical	ADJ
gs-4062	95	28	benefits	benefit	NOUN
gs-4062	95	29	.	.	PUNCT
gs-4062	96	1	the	the	DET
gs-4062	96	2	discussion	discussion	NOUN
gs-4062	96	3	will	will	AUX
gs-4062	96	4	explore	explore	VERB
gs-4062	96	5	the	the	DET
gs-4062	96	6	robust	robust	ADJ
gs-4062	96	7	clinical	clinical	ADJ
gs-4062	96	8	trial	trial	NOUN
gs-4062	96	9	data	datum	NOUN
gs-4062	96	10	that	that	PRON
gs-4062	96	11	underpins	underpin	VERB
gs-4062	96	12	their	their	PRON
gs-4062	96	13	efficacy	efficacy	NOUN
gs-4062	96	14	,	,	PUNCT
gs-4062	96	15	positioning	position	VERB
gs-4062	96	16	them	they	PRON
gs-4062	96	17	within	within	ADP
gs-4062	96	18	modern	modern	ADJ
gs-4062	96	19	treatment	treatment	NOUN
gs-4062	96	20	guidelines	guideline	NOUN
gs-4062	96	21	and	and	CCONJ
gs-4062	96	22	algorithms	algorithm	NOUN
gs-4062	96	23	.	.	PUNCT
gs-4062	97	1	a	a	DET
gs-4062	97	2	thorough	thorough	ADJ
gs-4062	97	3	analysis	analysis	NOUN
gs-4062	97	4	of	of	ADP
gs-4062	97	5	their	their	PRON
gs-4062	97	6	pharmacological	pharmacological	ADJ
gs-4062	97	7	profiles	profile	NOUN
gs-4062	97	8	—	—	PUNCT
gs-4062	97	9	including	include	VERB
gs-4062	97	10	absorption	absorption	NOUN
gs-4062	97	11	,	,	PUNCT
gs-4062	97	12	distribution	distribution	NOUN
gs-4062	97	13	,	,	PUNCT
gs-4062	97	14	metabolism	metabolism	NOUN
gs-4062	97	15	,	,	PUNCT
gs-4062	97	16	and	and	CCONJ
gs-4062	97	17	excretion	excretion	NOUN
gs-4062	97	18	—	—	PUNCT
gs-4062	97	19	will	will	AUX
gs-4062	97	20	be	be	AUX
gs-4062	97	21	presented	present	VERB
gs-4062	97	22	to	to	PART
gs-4062	97	23	elucidate	elucidate	VERB
gs-4062	97	24	their	their	PRON
gs-4062	97	25	dosing	dose	VERB
gs-4062	97	26	schedules	schedule	NOUN
gs-4062	97	27	and	and	CCONJ
gs-4062	97	28	interaction	interaction	NOUN
gs-4062	97	29	potentials	potential	NOUN
gs-4062	97	30	.	.	PUNCT
gs-4062	98	1	the	the	DET
gs-4062	98	2	review	review	NOUN
gs-4062	98	3	will	will	AUX
gs-4062	98	4	also	also	ADV
gs-4062	98	5	provide	provide	VERB
gs-4062	98	6	an	an	DET
gs-4062	98	7	honest	honest	ADJ
gs-4062	98	8	and	and	CCONJ
gs-4062	98	9	critical	critical	ADJ
gs-4062	98	10	appraisal	appraisal	NOUN
gs-4062	98	11	of	of	ADP
gs-4062	98	12	their	their	PRON
gs-4062	98	13	effects	effect	NOUN
gs-4062	98	14	and	and	CCONJ
gs-4062	98	15	toxicities	toxicity	NOUN
gs-4062	98	16	,	,	PUNCT
gs-4062	98	17	balancing	balance	VERB
gs-4062	98	18	their	their	PRON
gs-4062	98	19	remarkable	remarkable	ADJ
gs-4062	98	20	benefits	benefit	NOUN
gs-4062	98	21	against	against	ADP
gs-4062	98	22	emerging	emerge	VERB
gs-4062	98	23	safety	safety	NOUN
gs-4062	98	24	signals	signal	NOUN
gs-4062	98	25	like	like	ADP
gs-4062	98	26	weight	weight	NOUN
gs-4062	98	27	gain	gain	NOUN
gs-4062	98	28	and	and	CCONJ
gs-4062	98	29	neuropsychiatric	neuropsychiatric	ADJ
gs-4062	98	30	effects	effect	NOUN
gs-4062	98	31	.	.	PUNCT
gs-4062	99	1	finally	finally	ADV
gs-4062	99	2	,	,	PUNCT
gs-4062	99	3	the	the	DET
gs-4062	99	4	paper	paper	NOUN
gs-4062	99	5	will	will	AUX
gs-4062	99	6	confront	confront	VERB
gs-4062	99	7	the	the	DET
gs-4062	99	8	pressing	press	VERB
gs-4062	99	9	socio	socio	NOUN
gs-4062	99	10	-	-	PUNCT
gs-4062	99	11	economic	economic	ADJ
gs-4062	99	12	and	and	CCONJ
gs-4062	99	13	ethical	ethical	ADJ
gs-4062	99	14	implications	implication	NOUN
gs-4062	99	15	of	of	ADP
gs-4062	99	16	these	these	DET
gs-4062	99	17	advancements	advancement	NOUN
gs-4062	99	18	,	,	PUNCT
gs-4062	99	19	addressing	address	VERB
gs-4062	99	20	the	the	DET
gs-4062	99	21	urgent	urgent	ADJ
gs-4062	99	22	need	need	NOUN
gs-4062	99	23	for	for	ADP
gs-4062	99	24	strategies	strategy	NOUN
gs-4062	99	25	to	to	PART
gs-4062	99	26	ensure	ensure	VERB
gs-4062	99	27	that	that	SCONJ
gs-4062	99	28	the	the	DET
gs-4062	99	29	miracles	miracle	NOUN
gs-4062	99	30	of	of	ADP
gs-4062	99	31	modern	modern	ADJ
gs-4062	99	32	science	science	NOUN
gs-4062	99	33	do	do	AUX
gs-4062	99	34	not	not	PART
gs-4062	99	35	become	become	VERB
gs-4062	99	36	the	the	DET
gs-4062	99	37	exclusive	exclusive	ADJ
gs-4062	99	38	privilege	privilege	NOUN
gs-4062	99	39	of	of	ADP
gs-4062	99	40	the	the	DET
gs-4062	99	41	few	few	ADJ
gs-4062	99	42	,	,	PUNCT
gs-4062	99	43	but	but	CCONJ
gs-4062	99	44	are	be	AUX
gs-4062	99	45	mobilized	mobilize	VERB
gs-4062	99	46	to	to	PART
gs-4062	99	47	achieve	achieve	VERB
gs-4062	99	48	the	the	DET
gs-4062	99	49	ultimate	ultimate	ADJ
gs-4062	99	50	goal	goal	NOUN
gs-4062	99	51	of	of	ADP
gs-4062	99	52	ending	end	VERB
gs-4062	99	53	the	the	DET
gs-4062	99	54	aids	aids	PROPN
gs-4062	99	55	epidemic	epidemic	NOUN
gs-4062	99	56	for	for	ADP
gs-4062	99	57	everyone	everyone	PRON
gs-4062	99	58	,	,	PUNCT
gs-4062	99	59	everywhere	everywhere	ADV
gs-4062	99	60	.	.	PUNCT
gs-4062	100	1	this	this	DET
gs-4062	100	2	introduction	introduction	NOUN
gs-4062	100	3	sets	set	VERB
gs-4062	100	4	the	the	DET
gs-4062	100	5	stage	stage	NOUN
gs-4062	100	6	for	for	ADP
gs-4062	100	7	a	a	DET
gs-4062	100	8	deep	deep	ADJ
gs-4062	100	9	dive	dive	NOUN
gs-4062	100	10	into	into	ADP
gs-4062	100	11	the	the	DET
gs-4062	100	12	science	science	NOUN
gs-4062	100	13	,	,	PUNCT
gs-4062	100	14	medicine	medicine	NOUN
gs-4062	100	15	,	,	PUNCT
gs-4062	100	16	and	and	CCONJ
gs-4062	100	17	policy	policy	NOUN
gs-4062	100	18	of	of	ADP
gs-4062	100	19	the	the	DET
gs-4062	100	20	most	most	ADV
gs-4062	100	21	exciting	exciting	ADJ
gs-4062	100	22	and	and	CCONJ
gs-4062	100	23	promising	promising	ADJ
gs-4062	100	24	chapter	chapter	NOUN
gs-4062	100	25	in	in	ADP
gs-4062	100	26	the	the	DET
gs-4062	100	27	history	history	NOUN
gs-4062	100	28	of	of	ADP
gs-4062	100	29	hiv	hiv	PROPN
gs-4062	100	30	treatment	treatment	NOUN
gs-4062	100	31	.	.	PUNCT
gs-4062	101	1	the	the	DET
gs-4062	101	2	management	management	NOUN
gs-4062	101	3	of	of	ADP
gs-4062	101	4	human	human	ADJ
gs-4062	101	5	immunodeficiency	immunodeficiency	NOUN
gs-4062	101	6	virus	virus	NOUN
gs-4062	101	7	infection	infection	NOUN
gs-4062	101	8	has	have	AUX
gs-4062	101	9	undergone	undergo	VERB
gs-4062	101	10	a	a	DET
gs-4062	101	11	transformation	transformation	NOUN
gs-4062	101	12	so	so	ADV
gs-4062	101	13	profound	profound	ADJ
gs-4062	101	14	that	that	SCONJ
gs-4062	101	15	it	it	PRON
gs-4062	101	16	stands	stand	VERB
gs-4062	101	17	as	as	ADP
gs-4062	101	18	one	one	NUM
gs-4062	101	19	of	of	ADP
gs-4062	101	20	the	the	DET
gs-4062	101	21	most	most	ADV
gs-4062	101	22	remarkable	remarkable	ADJ
gs-4062	101	23	success	success	NOUN
gs-4062	101	24	stories	story	NOUN
gs-4062	101	25	in	in	ADP
gs-4062	101	26	modern	modern	ADJ
gs-4062	101	27	medicine	medicine	NOUN
gs-4062	101	28	.	.	PUNCT
gs-4062	102	1	from	from	ADP
gs-4062	102	2	a	a	DET
gs-4062	102	3	once	once	ADV
gs-4062	102	4	uniformly	uniformly	ADV
gs-4062	102	5	fatal	fatal	ADJ
gs-4062	102	6	diagnosis	diagnosis	NOUN
gs-4062	102	7	to	to	ADP
gs-4062	102	8	a	a	DET
gs-4062	102	9	chronic	chronic	NOUN
gs-4062	102	10	,	,	PUNCT
gs-4062	102	11	manageable	manageable	ADJ
gs-4062	102	12	condition	condition	NOUN
gs-4062	102	13	,	,	PUNCT
gs-4062	102	14	this	this	DET
gs-4062	102	15	evolution	evolution	NOUN
gs-4062	102	16	has	have	AUX
gs-4062	102	17	been	be	AUX
gs-4062	102	18	propelled	propel	VERB
gs-4062	102	19	by	by	ADP
gs-4062	102	20	an	an	DET
gs-4062	102	21	unwavering	unwavering	ADJ
gs-4062	102	22	scientific	scientific	ADJ
gs-4062	102	23	endeavor	endeavor	NOUN
gs-4062	102	24	to	to	PART
gs-4062	102	25	understand	understand	VERB
gs-4062	102	26	the	the	DET
gs-4062	102	27	intricate	intricate	ADJ
gs-4062	102	28	biology	biology	NOUN
gs-4062	102	29	of	of	ADP
gs-4062	102	30	the	the	DET
gs-4062	102	31	virus	virus	NOUN
gs-4062	102	32	and	and	CCONJ
gs-4062	102	33	to	to	PART
gs-4062	102	34	develop	develop	VERB
gs-4062	102	35	therapeutic	therapeutic	ADJ
gs-4062	102	36	agents	agent	NOUN
gs-4062	102	37	that	that	PRON
gs-4062	102	38	precisely	precisely	ADV
gs-4062	102	39	disrupt	disrupt	VERB
gs-4062	102	40	its	its	PRON
gs-4062	102	41	life	life	NOUN
gs-4062	102	42	cycle	cycle	NOUN
gs-4062	102	43	.	.	PUNCT
gs-4062	103	1	the	the	DET
gs-4062	103	2	early	early	ADJ
gs-4062	103	3	era	era	NOUN
gs-4062	103	4	of	of	ADP
gs-4062	103	5	antiretroviral	antiretroviral	ADJ
gs-4062	103	6	therapy	therapy	NOUN
gs-4062	103	7	,	,	PUNCT
gs-4062	103	8	characterized	characterize	VERB
gs-4062	103	9	by	by	ADP
gs-4062	103	10	monotherapies	monotherapie	NOUN
gs-4062	103	11	with	with	ADP
gs-4062	103	12	high	high	ADJ
gs-4062	103	13	pill	pill	NOUN
gs-4062	103	14	burdens	burden	NOUN
gs-4062	103	15	,	,	PUNCT
gs-4062	103	16	severe	severe	ADJ
gs-4062	103	17	toxicities	toxicity	NOUN
gs-4062	103	18	,	,	PUNCT
gs-4062	103	19	and	and	CCONJ
gs-4062	103	20	transient	transient	ADJ
gs-4062	103	21	efficacy	efficacy	NOUN
gs-4062	103	22	,	,	PUNCT
gs-4062	103	23	has	have	AUX
gs-4062	103	24	given	give	VERB
gs-4062	103	25	way	way	NOUN
gs-4062	103	26	to	to	ADP
gs-4062	103	27	a	a	DET
gs-4062	103	28	new	new	ADJ
gs-4062	103	29	epoch	epoch	NOUN
gs-4062	103	30	defined	define	VERB
gs-4062	103	31	by	by	ADP
gs-4062	103	32	highly	highly	ADV
gs-4062	103	33	potent	potent	ADJ
gs-4062	103	34	,	,	PUNCT
gs-4062	103	35	well	well	ADV
gs-4062	103	36	-	-	PUNCT
gs-4062	103	37	tolerated	tolerate	VERB
gs-4062	103	38	,	,	PUNCT
gs-4062	103	39	and	and	CCONJ
gs-4062	103	40	simplified	simplified	ADJ
gs-4062	103	41	treatment	treatment	NOUN
gs-4062	103	42	regimens	regimen	NOUN
gs-4062	103	43	.	.	PUNCT
gs-4062	104	1	this	this	DET
gs-4062	104	2	paradigm	paradigm	NOUN
gs-4062	104	3	shift	shift	NOUN
gs-4062	104	4	is	be	AUX
gs-4062	104	5	anchored	anchor	VERB
gs-4062	104	6	in	in	ADP
gs-4062	104	7	the	the	DET
gs-4062	104	8	continuous	continuous	ADJ
gs-4062	104	9	discovery	discovery	NOUN
gs-4062	104	10	and	and	CCONJ
gs-4062	104	11	development	development	NOUN
gs-4062	104	12	of	of	ADP
gs-4062	104	13	new	new	ADJ
gs-4062	104	14	antiretroviral	antiretroviral	ADJ
gs-4062	104	15	medicines	medicine	NOUN
gs-4062	104	16	,	,	PUNCT
gs-4062	104	17	each	each	PRON
gs-4062	104	18	belonging	belong	VERB
gs-4062	104	19	to	to	ADP
gs-4062	104	20	distinct	distinct	ADJ
gs-4062	104	21	pharmacological	pharmacological	ADJ
gs-4062	104	22	classes	class	NOUN
gs-4062	104	23	that	that	PRON
gs-4062	104	24	target	target	VERB
gs-4062	104	25	specific	specific	ADJ
gs-4062	104	26	vulnerabilities	vulnerability	NOUN
gs-4062	104	27	of	of	ADP
gs-4062	104	28	hiv	hiv	PROPN
gs-4062	104	29	.	.	PUNCT
gs-4062	105	1	the	the	DET
gs-4062	105	2	scientific	scientific	ADJ
gs-4062	105	3	discussion	discussion	NOUN
gs-4062	105	4	surrounding	surround	VERB
gs-4062	105	5	these	these	DET
gs-4062	105	6	new	new	ADJ
gs-4062	105	7	agents	agent	NOUN
gs-4062	105	8	is	be	AUX
gs-4062	105	9	multifaceted	multifaceted	ADJ
gs-4062	105	10	and	and	CCONJ
gs-4062	105	11	dynamic	dynamic	ADJ
gs-4062	105	12	,	,	PUNCT
gs-4062	105	13	reflecting	reflect	VERB
gs-4062	105	14	a	a	DET
gs-4062	105	15	deep	deep	ADJ
gs-4062	105	16	and	and	CCONJ
gs-4062	105	17	nuanced	nuanced	ADJ
gs-4062	105	18	understanding	understanding	NOUN
gs-4062	105	19	of	of	ADP
gs-4062	105	20	virology	virology	NOUN
gs-4062	105	21	,	,	PUNCT
gs-4062	105	22	pharmacology	pharmacology	NOUN
gs-4062	105	23	,	,	PUNCT
gs-4062	105	24	and	and	CCONJ
gs-4062	105	25	clinical	clinical	ADJ
gs-4062	105	26	medicine	medicine	NOUN
gs-4062	105	27	.	.	PUNCT
gs-4062	106	1	it	it	PRON
gs-4062	106	2	encompasses	encompass	VERB
gs-4062	106	3	a	a	DET
gs-4062	106	4	rigorous	rigorous	ADJ
gs-4062	106	5	process	process	NOUN
gs-4062	106	6	of	of	ADP
gs-4062	106	7	classification	classification	NOUN
gs-4062	106	8	based	base	VERB
gs-4062	106	9	on	on	ADP
gs-4062	106	10	molecular	molecular	ADJ
gs-4062	106	11	mechanism	mechanism	NOUN
gs-4062	106	12	,	,	PUNCT
gs-4062	106	13	a	a	DET
gs-4062	106	14	detailed	detailed	ADJ
gs-4062	106	15	georgian	georgian	NOUN
gs-4062	106	16	scientists/	scientists/	NUM
gs-4062	106	17	.	.	PUNCT
gs-4062	107	1	7	7	NUM
gs-4062	107	2	n	n	PRON
gs-4062	107	3	3	3	NUM
gs-4062	107	4	,	,	PUNCT
gs-4062	107	5	2025	2025	NUM
gs-4062	107	6	527	527	NUM
gs-4062	107	7	examination	examination	NOUN
gs-4062	107	8	of	of	ADP
gs-4062	107	9	their	their	PRON
gs-4062	107	10	unique	unique	ADJ
gs-4062	107	11	pharmacologic	pharmacologic	ADJ
gs-4062	107	12	features	feature	NOUN
gs-4062	107	13	,	,	PUNCT
gs-4062	107	14	and	and	CCONJ
gs-4062	107	15	a	a	DET
gs-4062	107	16	critical	critical	ADJ
gs-4062	107	17	appraisal	appraisal	NOUN
gs-4062	107	18	of	of	ADP
gs-4062	107	19	their	their	PRON
gs-4062	107	20	place	place	NOUN
gs-4062	107	21	in	in	ADP
gs-4062	107	22	clinical	clinical	ADJ
gs-4062	107	23	practice	practice	NOUN
gs-4062	107	24	through	through	ADP
gs-4062	107	25	evidence	evidence	NOUN
gs-4062	107	26	-	-	PUNCT
gs-4062	107	27	based	base	VERB
gs-4062	107	28	guidelines	guideline	NOUN
gs-4062	107	29	.	.	PUNCT
gs-4062	108	1	furthermore	furthermore	ADV
gs-4062	108	2	,	,	PUNCT
gs-4062	108	3	this	this	DET
gs-4062	108	4	discourse	discourse	NOUN
gs-4062	108	5	must	must	AUX
gs-4062	108	6	contend	contend	VERB
gs-4062	108	7	with	with	ADP
gs-4062	108	8	the	the	DET
gs-4062	108	9	dual	dual	ADJ
gs-4062	108	10	aspects	aspect	NOUN
gs-4062	108	11	of	of	ADP
gs-4062	108	12	their	their	PRON
gs-4062	108	13	effects	effect	NOUN
gs-4062	108	14	:	:	PUNCT
gs-4062	108	15	the	the	DET
gs-4062	108	16	profound	profound	ADJ
gs-4062	108	17	benefits	benefit	NOUN
gs-4062	108	18	of	of	ADP
gs-4062	108	19	sustained	sustain	VERB
gs-4062	108	20	virologic	virologic	ADJ
gs-4062	108	21	suppression	suppression	NOUN
gs-4062	108	22	and	and	CCONJ
gs-4062	108	23	immune	immune	ADJ
gs-4062	108	24	reconstitution	reconstitution	NOUN
gs-4062	108	25	,	,	PUNCT
gs-4062	108	26	and	and	CCONJ
gs-4062	108	27	the	the	DET
gs-4062	108	28	spectrum	spectrum	NOUN
gs-4062	108	29	of	of	ADP
gs-4062	108	30	potential	potential	ADJ
gs-4062	108	31	toxicities	toxicity	NOUN
gs-4062	108	32	,	,	PUNCT
gs-4062	108	33	which	which	PRON
gs-4062	108	34	range	range	VERB
gs-4062	108	35	from	from	ADP
gs-4062	108	36	acute	acute	ADJ
gs-4062	108	37	adverse	adverse	ADJ
gs-4062	108	38	events	event	NOUN
gs-4062	108	39	to	to	ADP
gs-4062	108	40	long	long	ADJ
gs-4062	108	41	-	-	PUNCT
gs-4062	108	42	term	term	NOUN
gs-4062	108	43	metabolic	metabolic	NOUN
gs-4062	108	44	complications	complication	NOUN
gs-4062	108	45	.	.	PUNCT
gs-4062	109	1	the	the	DET
gs-4062	109	2	ongoing	ongoing	ADJ
gs-4062	109	3	challenge	challenge	NOUN
gs-4062	109	4	of	of	ADP
gs-4062	109	5	drug	drug	NOUN
gs-4062	109	6	resistance	resistance	NOUN
gs-4062	109	7	necessitates	necessitate	VERB
gs-4062	109	8	a	a	DET
gs-4062	109	9	vigilant	vigilant	ADJ
gs-4062	109	10	surveillance	surveillance	NOUN
gs-4062	109	11	of	of	ADP
gs-4062	109	12	mutational	mutational	ADJ
gs-4062	109	13	patterns	pattern	NOUN
gs-4062	109	14	and	and	CCONJ
gs-4062	109	15	informs	inform	VERB
gs-4062	109	16	the	the	DET
gs-4062	109	17	strategic	strategic	ADJ
gs-4062	109	18	sequencing	sequencing	NOUN
gs-4062	109	19	of	of	ADP
gs-4062	109	20	therapeutic	therapeutic	ADJ
gs-4062	109	21	options	option	NOUN
gs-4062	109	22	.	.	PUNCT
gs-4062	110	1	this	this	DET
gs-4062	110	2	article	article	NOUN
gs-4062	110	3	aims	aim	VERB
gs-4062	110	4	to	to	PART
gs-4062	110	5	manifest	manifest	VERB
gs-4062	110	6	this	this	DET
gs-4062	110	7	comprehensive	comprehensive	ADJ
gs-4062	110	8	scientific	scientific	ADJ
gs-4062	110	9	discussion	discussion	NOUN
gs-4062	110	10	,	,	PUNCT
gs-4062	110	11	exploring	explore	VERB
gs-4062	110	12	the	the	DET
gs-4062	110	13	classification	classification	NOUN
gs-4062	110	14	,	,	PUNCT
gs-4062	110	15	clinical	clinical	ADJ
gs-4062	110	16	use	use	NOUN
gs-4062	110	17	,	,	PUNCT
gs-4062	110	18	features	feature	NOUN
gs-4062	110	19	,	,	PUNCT
gs-4062	110	20	mechanism	mechanism	NOUN
gs-4062	110	21	of	of	ADP
gs-4062	110	22	action	action	NOUN
gs-4062	110	23	,	,	PUNCT
gs-4062	110	24	pharmacology	pharmacology	NOUN
gs-4062	110	25	,	,	PUNCT
gs-4062	110	26	and	and	CCONJ
gs-4062	110	27	the	the	DET
gs-4062	110	28	delicate	delicate	ADJ
gs-4062	110	29	balance	balance	NOUN
gs-4062	110	30	between	between	ADP
gs-4062	110	31	effects	effect	NOUN
gs-4062	110	32	and	and	CCONJ
gs-4062	110	33	toxicities	toxicity	NOUN
gs-4062	110	34	that	that	PRON
gs-4062	110	35	define	define	VERB
gs-4062	110	36	the	the	DET
gs-4062	110	37	current	current	ADJ
gs-4062	110	38	and	and	CCONJ
gs-4062	110	39	future	future	ADJ
gs-4062	110	40	landscape	landscape	NOUN
gs-4062	110	41	of	of	ADP
gs-4062	110	42	new	new	ADJ
gs-4062	110	43	anti	anti	ADJ
gs-4062	110	44	-	-	ADJ
gs-4062	110	45	hiv	hiv	ADJ
gs-4062	110	46	medicines	medicine	NOUN
gs-4062	110	47	.	.	PUNCT
gs-4062	111	1	the	the	DET
gs-4062	111	2	features	feature	NOUN
gs-4062	111	3	of	of	ADP
gs-4062	111	4	new	new	ADJ
gs-4062	111	5	antiretroviral	antiretroviral	ADJ
gs-4062	111	6	medicines	medicine	NOUN
gs-4062	111	7	are	be	AUX
gs-4062	111	8	meticulously	meticulously	ADV
gs-4062	111	9	engineered	engineer	VERB
gs-4062	111	10	to	to	PART
gs-4062	111	11	overcome	overcome	VERB
gs-4062	111	12	the	the	DET
gs-4062	111	13	limitations	limitation	NOUN
gs-4062	111	14	of	of	ADP
gs-4062	111	15	their	their	PRON
gs-4062	111	16	predecessors	predecessor	NOUN
gs-4062	111	17	.	.	PUNCT
gs-4062	112	1	key	key	ADJ
gs-4062	112	2	characteristics	characteristic	NOUN
gs-4062	112	3	dominating	dominate	VERB
gs-4062	112	4	scientific	scientific	ADJ
gs-4062	112	5	evaluation	evaluation	NOUN
gs-4062	112	6	include	include	VERB
gs-4062	112	7	:	:	PUNCT
gs-4062	112	8	high	high	ADJ
gs-4062	112	9	potency	potency	NOUN
gs-4062	112	10	:	:	PUNCT
gs-4062	112	11	achieving	achieve	VERB
gs-4062	112	12	deep	deep	ADJ
gs-4062	112	13	and	and	CCONJ
gs-4062	112	14	rapid	rapid	ADJ
gs-4062	112	15	virological	virological	ADJ
gs-4062	112	16	suppression	suppression	NOUN
gs-4062	112	17	at	at	ADP
gs-4062	112	18	low	low	ADJ
gs-4062	112	19	doses	dose	NOUN
gs-4062	112	20	.	.	PUNCT
gs-4062	113	1	high	high	ADJ
gs-4062	113	2	genetic	genetic	ADJ
gs-4062	113	3	barrier	barrier	NOUN
gs-4062	113	4	to	to	ADP
gs-4062	113	5	resistance	resistance	NOUN
gs-4062	113	6	:	:	PUNCT
gs-4062	113	7	requiring	require	VERB
gs-4062	113	8	multiple	multiple	ADJ
gs-4062	113	9	mutations	mutation	NOUN
gs-4062	113	10	for	for	ADP
gs-4062	113	11	the	the	DET
gs-4062	113	12	virus	virus	NOUN
gs-4062	113	13	to	to	PART
gs-4062	113	14	significantly	significantly	ADV
gs-4062	113	15	reduce	reduce	VERB
gs-4062	113	16	susceptibility	susceptibility	NOUN
gs-4062	113	17	,	,	PUNCT
gs-4062	113	18	a	a	DET
gs-4062	113	19	hallmark	hallmark	NOUN
gs-4062	113	20	of	of	ADP
gs-4062	113	21	drugs	drug	NOUN
gs-4062	113	22	like	like	ADP
gs-4062	113	23	dolutegravir	dolutegravir	NOUN
gs-4062	113	24	and	and	CCONJ
gs-4062	113	25	bictegravir	bictegravir	PROPN
gs-4062	113	26	.	.	PUNCT
gs-4062	114	1	improved	improve	VERB
gs-4062	114	2	safety	safety	NOUN
gs-4062	114	3	and	and	CCONJ
gs-4062	114	4	tolerability	tolerability	NOUN
gs-4062	114	5	profiles	profile	NOUN
gs-4062	114	6	:	:	PUNCT
gs-4062	114	7	designed	design	VERB
gs-4062	114	8	to	to	PART
gs-4062	114	9	minimize	minimize	VERB
gs-4062	114	10	off	off	ADP
gs-4062	114	11	-	-	PUNCT
gs-4062	114	12	target	target	NOUN
gs-4062	114	13	effects	effect	NOUN
gs-4062	114	14	and	and	CCONJ
gs-4062	114	15	chronic	chronic	ADJ
gs-4062	114	16	toxicities	toxicity	NOUN
gs-4062	114	17	associated	associate	VERB
gs-4062	114	18	with	with	ADP
gs-4062	114	19	older	old	ADJ
gs-4062	114	20	drugs	drug	NOUN
gs-4062	114	21	(	(	PUNCT
gs-4062	114	22	e.g.	e.g.	ADV
gs-4062	114	23	,	,	PUNCT
gs-4062	114	24	mitochondrial	mitochondrial	ADJ
gs-4062	114	25	toxicity	toxicity	NOUN
gs-4062	114	26	with	with	ADP
gs-4062	114	27	older	old	ADJ
gs-4062	114	28	nrtis	nrtis	NOUN
gs-4062	114	29	,	,	PUNCT
gs-4062	114	30	dyslipidemia	dyslipidemia	VERB
gs-4062	114	31	with	with	ADP
gs-4062	114	32	pis	pis	NOUN
gs-4062	114	33	)	)	PUNCT
gs-4062	114	34	.	.	PUNCT
gs-4062	115	1	favorable	favorable	ADJ
gs-4062	115	2	pharmacokinetics	pharmacokinetic	NOUN
gs-4062	115	3	:	:	PUNCT
gs-4062	115	4	offering	offer	VERB
gs-4062	115	5	long	long	ADJ
gs-4062	115	6	half	half	ADJ
gs-4062	115	7	-	-	PUNCT
gs-4062	115	8	lives	life	NOUN
gs-4062	115	9	that	that	PRON
gs-4062	115	10	permit	permit	VERB
gs-4062	115	11	once	once	ADV
gs-4062	115	12	-	-	PUNCT
gs-4062	115	13	daily	daily	ADV
gs-4062	115	14	dosing	dosing	NOUN
gs-4062	115	15	and	and	CCONJ
gs-4062	115	16	forgive	forgive	VERB
gs-4062	115	17	occasional	occasional	ADJ
gs-4062	115	18	missed	miss	VERB
gs-4062	115	19	doses	dose	NOUN
gs-4062	115	20	,	,	PUNCT
gs-4062	115	21	enhancing	enhance	VERB
gs-4062	115	22	adherence	adherence	NOUN
gs-4062	115	23	.	.	PUNCT
gs-4062	116	1	some	some	PRON
gs-4062	116	2	are	be	AUX
gs-4062	116	3	engineered	engineer	VERB
gs-4062	116	4	to	to	PART
gs-4062	116	5	be	be	AUX
gs-4062	116	6	boosed	boose	VERB
gs-4062	116	7	by	by	ADP
gs-4062	116	8	pharmacoenhancers	pharmacoenhancer	NOUN
gs-4062	116	9	without	without	ADP
gs-4062	116	10	the	the	DET
gs-4062	116	11	food	food	NOUN
gs-4062	116	12	requirements	requirement	NOUN
gs-4062	116	13	of	of	ADP
gs-4062	116	14	older	old	ADJ
gs-4062	116	15	agents	agent	NOUN
gs-4062	116	16	.	.	PUNCT
gs-4062	117	1	low	low	ADJ
gs-4062	117	2	drug	drug	NOUN
gs-4062	117	3	-	-	PUNCT
gs-4062	117	4	drug	drug	NOUN
gs-4062	117	5	interaction	interaction	NOUN
gs-4062	117	6	potential	potential	NOUN
gs-4062	117	7	:	:	PUNCT
gs-4062	117	8	reducing	reduce	VERB
gs-4062	117	9	complex	complex	ADJ
gs-4062	117	10	interaction	interaction	NOUN
gs-4062	117	11	profiles	profile	NOUN
gs-4062	117	12	,	,	PUNCT
gs-4062	117	13	especially	especially	ADV
gs-4062	117	14	with	with	ADP
gs-4062	117	15	comedications	comedication	NOUN
gs-4062	117	16	for	for	ADP
gs-4062	117	17	common	common	ADJ
gs-4062	117	18	comorbidities	comorbiditie	NOUN
gs-4062	117	19	,	,	PUNCT
gs-4062	117	20	a	a	DET
gs-4062	117	21	critical	critical	ADJ
gs-4062	117	22	feature	feature	NOUN
gs-4062	117	23	in	in	ADP
gs-4062	117	24	an	an	DET
gs-4062	117	25	aging	age	VERB
gs-4062	117	26	hiv	hiv	NOUN
gs-4062	117	27	-	-	PUNCT
gs-4062	117	28	positive	positive	ADJ
gs-4062	117	29	population	population	NOUN
gs-4062	117	30	.	.	PUNCT
gs-4062	118	1	formulation	formulation	NOUN
gs-4062	118	2	advancements	advancement	NOUN
gs-4062	118	3	:	:	PUNCT
gs-4062	118	4	including	include	VERB
gs-4062	118	5	fixed	fix	VERB
gs-4062	118	6	-	-	PUNCT
gs-4062	118	7	dose	dose	NOUN
gs-4062	118	8	combinations	combination	NOUN
gs-4062	118	9	(	(	PUNCT
gs-4062	118	10	fdcs	fdc	NOUN
gs-4062	118	11	)	)	PUNCT
gs-4062	118	12	that	that	PRON
gs-4062	118	13	consolidate	consolidate	VERB
gs-4062	118	14	entire	entire	ADJ
gs-4062	118	15	regimens	regimen	NOUN
gs-4062	118	16	into	into	ADP
gs-4062	118	17	a	a	DET
gs-4062	118	18	single	single	ADJ
gs-4062	118	19	tablet	tablet	NOUN
gs-4062	118	20	(	(	PUNCT
gs-4062	118	21	e.g.	e.g.	ADV
gs-4062	118	22	,	,	PUNCT
gs-4062	118	23	biktarvy	biktarvy	PROPN
gs-4062	118	24	®	®	NOUN
gs-4062	118	25	:	:	PUNCT
gs-4062	118	26	bictegravir	bictegravir	PROPN
gs-4062	118	27	/	/	SYM
gs-4062	118	28	emtricitabine	emtricitabine	PROPN
gs-4062	118	29	/	/	SYM
gs-4062	118	30	tenofovir	tenofovir	PROPN
gs-4062	118	31	alafenamide	alafenamide	PROPN
gs-4062	118	32	)	)	PUNCT
gs-4062	118	33	and	and	CCONJ
gs-4062	118	34	long	long	ADV
gs-4062	118	35	-	-	PUNCT
gs-4062	118	36	acting	act	VERB
gs-4062	118	37	injectables	injectable	NOUN
gs-4062	118	38	that	that	PRON
gs-4062	118	39	provide	provide	VERB
gs-4062	118	40	months	month	NOUN
gs-4062	118	41	of	of	ADP
gs-4062	118	42	coverage	coverage	NOUN
gs-4062	118	43	.	.	PUNCT
gs-4062	119	1	the	the	DET
gs-4062	119	2	mechanism	mechanism	NOUN
gs-4062	119	3	of	of	ADP
gs-4062	119	4	action	action	NOUN
gs-4062	119	5	is	be	AUX
gs-4062	119	6	the	the	DET
gs-4062	119	7	foundational	foundational	ADJ
gs-4062	119	8	pillar	pillar	NOUN
gs-4062	119	9	upon	upon	SCONJ
gs-4062	119	10	which	which	PRON
gs-4062	119	11	each	each	DET
gs-4062	119	12	drug	drug	NOUN
gs-4062	119	13	is	be	AUX
gs-4062	119	14	built	build	VERB
gs-4062	119	15	,	,	PUNCT
gs-4062	119	16	and	and	CCONJ
gs-4062	119	17	for	for	ADP
gs-4062	119	18	new	new	ADJ
gs-4062	119	19	agents	agent	NOUN
gs-4062	119	20	,	,	PUNCT
gs-4062	119	21	it	it	PRON
gs-4062	119	22	often	often	ADV
gs-4062	119	23	involves	involve	VERB
gs-4062	119	24	refined	refined	ADJ
gs-4062	119	25	inhibition	inhibition	NOUN
gs-4062	119	26	or	or	CCONJ
gs-4062	119	27	entirely	entirely	ADV
gs-4062	119	28	novel	novel	ADJ
gs-4062	119	29	targets	target	NOUN
gs-4062	119	30	.	.	PUNCT
gs-4062	120	1	the	the	DET
gs-4062	120	2	insti	insti	PROPN
gs-4062	120	3	class	class	PROPN
gs-4062	120	4	exemplifies	exemplify	VERB
gs-4062	120	5	refinement	refinement	NOUN
gs-4062	120	6	.	.	PUNCT
gs-4062	121	1	while	while	SCONJ
gs-4062	121	2	all	all	DET
gs-4062	121	3	instis	insti	NOUN
gs-4062	121	4	block	block	VERB
gs-4062	121	5	the	the	DET
gs-4062	121	6	integration	integration	NOUN
gs-4062	121	7	of	of	ADP
gs-4062	121	8	viral	viral	ADJ
gs-4062	121	9	dna	dna	NOUN
gs-4062	121	10	into	into	ADP
gs-4062	121	11	the	the	DET
gs-4062	121	12	host	host	NOUN
gs-4062	121	13	genome	genome	NOUN
gs-4062	121	14	,	,	PUNCT
gs-4062	121	15	secondgeneration	secondgeneration	NOUN
gs-4062	121	16	instis	instis	PROPN
gs-4062	121	17	like	like	ADP
gs-4062	121	18	dolutegravir	dolutegravir	NOUN
gs-4062	121	19	bind	bind	VERB
gs-4062	121	20	more	more	ADV
gs-4062	121	21	tightly	tightly	ADV
gs-4062	121	22	to	to	ADP
gs-4062	121	23	the	the	DET
gs-4062	121	24	integrase	integrase	NOUN
gs-4062	121	25	enzyme	enzyme	NOUN
gs-4062	121	26	and	and	CCONJ
gs-4062	121	27	demonstrate	demonstrate	VERB
gs-4062	121	28	slower	slow	ADJ
gs-4062	121	29	dissociation	dissociation	NOUN
gs-4062	121	30	kinetics	kinetic	NOUN
gs-4062	121	31	,	,	PUNCT
gs-4062	121	32	contributing	contribute	VERB
gs-4062	121	33	to	to	ADP
gs-4062	121	34	their	their	PRON
gs-4062	121	35	superior	superior	ADJ
gs-4062	121	36	resistance	resistance	NOUN
gs-4062	121	37	profile	profile	NOUN
gs-4062	121	38	.	.	PUNCT
gs-4062	122	1	in	in	ADP
gs-4062	122	2	stark	stark	ADJ
gs-4062	122	3	contrast	contrast	NOUN
gs-4062	122	4	,	,	PUNCT
gs-4062	122	5	the	the	DET
gs-4062	122	6	newest	new	ADJ
gs-4062	122	7	classes	class	NOUN
gs-4062	122	8	of	of	ADP
gs-4062	122	9	drugs	drug	NOUN
gs-4062	122	10	unveil	unveil	VERB
gs-4062	122	11	novel	novel	ADJ
gs-4062	122	12	viral	viral	ADJ
gs-4062	122	13	vulnerabilities	vulnerability	NOUN
gs-4062	122	14	.	.	PUNCT
gs-4062	123	1	fostemsavir	fostemsavir	PROPN
gs-4062	123	2	,	,	PUNCT
gs-4062	123	3	an	an	DET
gs-4062	123	4	attachment	attachment	NOUN
gs-4062	123	5	inhibitor	inhibitor	NOUN
gs-4062	123	6	,	,	PUNCT
gs-4062	123	7	binds	bind	VERB
gs-4062	123	8	to	to	ADP
gs-4062	123	9	the	the	DET
gs-4062	123	10	envelope	envelope	NOUN
gs-4062	123	11	glycoprotein	glycoprotein	NOUN
gs-4062	123	12	gp120	gp120	PROPN
gs-4062	123	13	on	on	ADP
gs-4062	123	14	the	the	DET
gs-4062	123	15	virus	virus	NOUN
gs-4062	123	16	surface	surface	NOUN
gs-4062	123	17	,	,	PUNCT
gs-4062	123	18	preventing	prevent	VERB
gs-4062	123	19	its	its	PRON
gs-4062	123	20	initial	initial	ADJ
gs-4062	123	21	interaction	interaction	NOUN
gs-4062	123	22	with	with	ADP
gs-4062	123	23	the	the	DET
gs-4062	123	24	cd4	cd4	PROPN
gs-4062	123	25	receptor	receptor	NOUN
gs-4062	123	26	on	on	ADP
gs-4062	123	27	the	the	DET
gs-4062	123	28	host	host	NOUN
gs-4062	123	29	cell	cell	NOUN
gs-4062	123	30	—	—	PUNCT
gs-4062	123	31	the	the	DET
gs-4062	123	32	very	very	ADV
gs-4062	123	33	first	first	ADJ
gs-4062	123	34	step	step	NOUN
gs-4062	123	35	of	of	ADP
gs-4062	123	36	infection	infection	NOUN
gs-4062	123	37	.	.	PUNCT
gs-4062	124	1	lenacapavir	lenacapavir	PROPN
gs-4062	124	2	,	,	PUNCT
gs-4062	124	3	the	the	DET
gs-4062	124	4	first	first	ADJ
gs-4062	124	5	-	-	PUNCT
gs-4062	124	6	in	in	ADP
gs-4062	124	7	-	-	PUNCT
gs-4062	124	8	class	class	NOUN
gs-4062	124	9	capsid	capsid	NOUN
gs-4062	124	10	inhibitor	inhibitor	NOUN
gs-4062	124	11	,	,	PUNCT
gs-4062	124	12	represents	represent	VERB
gs-4062	124	13	a	a	DET
gs-4062	124	14	monumental	monumental	ADJ
gs-4062	124	15	leap	leap	NOUN
gs-4062	124	16	.	.	PUNCT
gs-4062	125	1	it	it	PRON
gs-4062	125	2	exhibits	exhibit	VERB
gs-4062	125	3	a	a	DET
gs-4062	125	4	multi	multi	ADJ
gs-4062	125	5	-	-	ADJ
gs-4062	125	6	stage	stage	NOUN
gs-4062	125	7	mechanism	mechanism	NOUN
gs-4062	125	8	:	:	PUNCT
gs-4062	125	9	it	it	PRON
gs-4062	125	10	disrupts	disrupt	VERB
gs-4062	125	11	the	the	DET
gs-4062	125	12	capsid	capsid	PROPN
gs-4062	125	13	core	core	NOUN
gs-4062	125	14	,	,	PUNCT
gs-4062	125	15	interfering	interfere	VERB
gs-4062	125	16	with	with	ADP
gs-4062	125	17	both	both	CCONJ
gs-4062	125	18	the	the	DET
gs-4062	125	19	nuclear	nuclear	ADJ
gs-4062	125	20	import	import	NOUN
gs-4062	125	21	of	of	ADP
gs-4062	125	22	viral	viral	ADJ
gs-4062	125	23	dna	dna	NOUN
gs-4062	125	24	and	and	CCONJ
gs-4062	125	25	the	the	DET
gs-4062	125	26	assembly	assembly	NOUN
gs-4062	125	27	and	and	CCONJ
gs-4062	125	28	maturation	maturation	NOUN
gs-4062	125	29	of	of	ADP
gs-4062	125	30	new	new	ADJ
gs-4062	125	31	virions	virion	NOUN
gs-4062	125	32	.	.	PUNCT
gs-4062	126	1	this	this	DET
gs-4062	126	2	novel	novel	ADJ
gs-4062	126	3	target	target	NOUN
gs-4062	126	4	makes	make	VERB
gs-4062	126	5	it	it	PRON
gs-4062	126	6	a	a	DET
gs-4062	126	7	powerful	powerful	ADJ
gs-4062	126	8	option	option	NOUN
gs-4062	126	9	for	for	ADP
gs-4062	126	10	heavily	heavily	ADV
gs-4062	126	11	treatment	treatment	NOUN
gs-4062	126	12	-	-	PUNCT
gs-4062	126	13	experienced	experience	VERB
gs-4062	126	14	patients	patient	NOUN
gs-4062	126	15	and	and	CCONJ
gs-4062	126	16	is	be	AUX
gs-4062	126	17	being	be	AUX
gs-4062	126	18	studied	study	VERB
gs-4062	126	19	in	in	ADP
gs-4062	126	20	long	long	ADV
gs-4062	126	21	-	-	PUNCT
gs-4062	126	22	acting	act	VERB
gs-4062	126	23	formulations	formulation	NOUN
gs-4062	126	24	.	.	PUNCT
gs-4062	127	1	the	the	DET
gs-4062	127	2	scientific	scientific	ADJ
gs-4062	127	3	discussion	discussion	NOUN
gs-4062	127	4	around	around	ADP
gs-4062	127	5	mechanism	mechanism	NOUN
gs-4062	127	6	is	be	AUX
gs-4062	127	7	deeply	deeply	ADV
gs-4062	127	8	intertwined	intertwine	VERB
gs-4062	127	9	with	with	ADP
gs-4062	127	10	resistance	resistance	NOUN
gs-4062	127	11	profiling	profiling	NOUN
gs-4062	127	12	,	,	PUNCT
gs-4062	127	13	using	use	VERB
gs-4062	127	14	structural	structural	ADJ
gs-4062	127	15	biology	biology	NOUN
gs-4062	127	16	and	and	CCONJ
gs-4062	127	17	virological	virological	ADJ
gs-4062	127	18	assays	assay	NOUN
gs-4062	127	19	to	to	PART
gs-4062	127	20	understand	understand	VERB
gs-4062	127	21	how	how	SCONJ
gs-4062	127	22	mutations	mutation	NOUN
gs-4062	127	23	confer	confer	VERB
gs-4062	127	24	resistance	resistance	NOUN
gs-4062	127	25	and	and	CCONJ
gs-4062	127	26	to	to	PART
gs-4062	127	27	inform	inform	VERB
gs-4062	127	28	the	the	DET
gs-4062	127	29	development	development	NOUN
gs-4062	127	30	of	of	ADP
gs-4062	127	31	nextgeneration	nextgeneration	NOUN
gs-4062	127	32	inhibitors	inhibitor	NOUN
gs-4062	127	33	.	.	PUNCT
gs-4062	128	1	the	the	DET
gs-4062	128	2	pharmacological	pharmacological	ADJ
gs-4062	128	3	profile	profile	NOUN
gs-4062	128	4	—	—	PUNCT
gs-4062	128	5	encompassing	encompass	VERB
gs-4062	128	6	pharmacokinetics	pharmacokinetic	NOUN
gs-4062	128	7	(	(	PUNCT
gs-4062	128	8	what	what	PRON
gs-4062	128	9	the	the	DET
gs-4062	128	10	body	body	NOUN
gs-4062	128	11	does	do	AUX
gs-4062	128	12	to	to	ADP
gs-4062	128	13	the	the	DET
gs-4062	128	14	drug	drug	NOUN
gs-4062	128	15	)	)	PUNCT
gs-4062	128	16	and	and	CCONJ
gs-4062	128	17	pharmacodynamics	pharmacodynamic	NOUN
gs-4062	128	18	(	(	PUNCT
gs-4062	128	19	what	what	PRON
gs-4062	128	20	the	the	DET
gs-4062	128	21	drug	drug	NOUN
gs-4062	128	22	does	do	AUX
gs-4062	128	23	to	to	ADP
gs-4062	128	24	the	the	DET
gs-4062	128	25	body)—is	body)—is	CCONJ
gs-4062	128	26	a	a	DET
gs-4062	128	27	critical	critical	ADJ
gs-4062	128	28	area	area	NOUN
gs-4062	128	29	of	of	ADP
gs-4062	128	30	intense	intense	ADJ
gs-4062	128	31	research	research	NOUN
gs-4062	128	32	and	and	CCONJ
gs-4062	128	33	georgian	georgian	NOUN
gs-4062	128	34	scientists/	scientists/	NUM
gs-4062	128	35	.	.	PUNCT
gs-4062	129	1	7	7	NUM
gs-4062	129	2	n	n	PRON
gs-4062	129	3	3	3	NUM
gs-4062	129	4	,	,	PUNCT
gs-4062	129	5	2025	2025	NUM
gs-4062	129	6	528	528	NUM
gs-4062	129	7	debate	debate	NOUN
gs-4062	129	8	.	.	PUNCT
gs-4062	130	1	for	for	ADP
gs-4062	130	2	new	new	ADJ
gs-4062	130	3	antiretrovirals	antiretroviral	NOUN
gs-4062	130	4	,	,	PUNCT
gs-4062	130	5	the	the	DET
gs-4062	130	6	focus	focus	NOUN
gs-4062	130	7	is	be	AUX
gs-4062	130	8	on	on	ADP
gs-4062	130	9	optimizing	optimize	VERB
gs-4062	130	10	absorption	absorption	NOUN
gs-4062	130	11	,	,	PUNCT
gs-4062	130	12	distribution	distribution	NOUN
gs-4062	130	13	,	,	PUNCT
gs-4062	130	14	metabolism	metabolism	NOUN
gs-4062	130	15	,	,	PUNCT
gs-4062	130	16	and	and	CCONJ
gs-4062	130	17	excretion	excretion	NOUN
gs-4062	130	18	(	(	PUNCT
gs-4062	130	19	adme	adme	NOUN
gs-4062	130	20	)	)	PUNCT
gs-4062	130	21	properties	property	NOUN
gs-4062	130	22	.	.	PUNCT
gs-4062	131	1	a	a	DET
gs-4062	131	2	prime	prime	ADJ
gs-4062	131	3	example	example	NOUN
gs-4062	131	4	is	be	AUX
gs-4062	131	5	the	the	DET
gs-4062	131	6	development	development	NOUN
gs-4062	131	7	of	of	ADP
gs-4062	131	8	tenofovir	tenofovir	PROPN
gs-4062	131	9	alafenamide	alafenamide	PROPN
gs-4062	131	10	(	(	PUNCT
gs-4062	131	11	taf	taf	PROPN
gs-4062	131	12	)	)	PUNCT
gs-4062	131	13	,	,	PUNCT
gs-4062	131	14	a	a	DET
gs-4062	131	15	prodrug	prodrug	NOUN
gs-4062	131	16	of	of	ADP
gs-4062	131	17	tenofovir	tenofovir	NOUN
gs-4062	131	18	.	.	PUNCT
gs-4062	132	1	compared	compare	VERB
gs-4062	132	2	to	to	ADP
gs-4062	132	3	its	its	PRON
gs-4062	132	4	predecessor	predecessor	NOUN
gs-4062	132	5	,	,	PUNCT
gs-4062	132	6	tenofovir	tenofovir	NOUN
gs-4062	132	7	disoproxil	disoproxil	VERB
gs-4062	132	8	fumarate	fumarate	NOUN
gs-4062	132	9	(	(	PUNCT
gs-4062	132	10	tdf	tdf	PROPN
gs-4062	132	11	)	)	PUNCT
gs-4062	132	12	,	,	PUNCT
gs-4062	132	13	taf	taf	X
gs-4062	132	14	is	be	AUX
gs-4062	132	15	more	more	ADV
gs-4062	132	16	stable	stable	ADJ
gs-4062	132	17	in	in	ADP
gs-4062	132	18	plasma	plasma	NOUN
gs-4062	132	19	,	,	PUNCT
gs-4062	132	20	leading	lead	VERB
gs-4062	132	21	to	to	ADP
gs-4062	132	22	more	more	ADV
gs-4062	132	23	efficient	efficient	ADJ
gs-4062	132	24	intracellular	intracellular	ADJ
gs-4062	132	25	delivery	delivery	NOUN
gs-4062	132	26	of	of	ADP
gs-4062	132	27	the	the	DET
gs-4062	132	28	active	active	ADJ
gs-4062	132	29	metabolite	metabolite	NOUN
gs-4062	132	30	,	,	PUNCT
gs-4062	132	31	significantly	significantly	ADV
gs-4062	132	32	higher	high	ADJ
gs-4062	132	33	lymphatic	lymphatic	ADJ
gs-4062	132	34	and	and	CCONJ
gs-4062	132	35	tissue	tissue	NOUN
gs-4062	132	36	concentrations	concentration	NOUN
gs-4062	132	37	,	,	PUNCT
gs-4062	132	38	and	and	CCONJ
gs-4062	132	39	markedly	markedly	ADV
gs-4062	132	40	lower	low	ADJ
gs-4062	132	41	systemic	systemic	ADJ
gs-4062	132	42	exposure	exposure	NOUN
gs-4062	132	43	.	.	PUNCT
gs-4062	133	1	this	this	PRON
gs-4062	133	2	translates	translate	VERB
gs-4062	133	3	into	into	ADP
gs-4062	133	4	a	a	DET
gs-4062	133	5	vastly	vastly	ADV
gs-4062	133	6	improved	improve	VERB
gs-4062	133	7	renal	renal	ADJ
gs-4062	133	8	and	and	CCONJ
gs-4062	133	9	bone	bone	NOUN
gs-4062	133	10	safety	safety	NOUN
gs-4062	133	11	profile	profile	NOUN
gs-4062	133	12	.	.	PUNCT
gs-4062	134	1	the	the	DET
gs-4062	134	2	discussion	discussion	NOUN
gs-4062	134	3	also	also	ADV
gs-4062	134	4	extensively	extensively	ADV
gs-4062	134	5	covers	cover	VERB
gs-4062	134	6	drug	drug	NOUN
gs-4062	134	7	-	-	PUNCT
gs-4062	134	8	drug	drug	NOUN
gs-4062	134	9	interactions	interaction	NOUN
gs-4062	134	10	(	(	PUNCT
gs-4062	134	11	ddis	ddis	NOUN
gs-4062	134	12	)	)	PUNCT
gs-4062	134	13	,	,	PUNCT
gs-4062	134	14	particularly	particularly	ADV
gs-4062	134	15	for	for	ADP
gs-4062	134	16	agents	agent	NOUN
gs-4062	134	17	metabolized	metabolize	VERB
gs-4062	134	18	by	by	ADP
gs-4062	134	19	cytochrome	cytochrome	ADJ
gs-4062	134	20	p450	p450	NUM
gs-4062	134	21	enzymes	enzyme	NOUN
gs-4062	134	22	or	or	CCONJ
gs-4062	134	23	acting	act	VERB
gs-4062	134	24	as	as	ADP
gs-4062	134	25	inducers	inducer	NOUN
gs-4062	134	26	/	/	SYM
gs-4062	134	27	inhibitors	inhibitor	NOUN
gs-4062	134	28	of	of	ADP
gs-4062	134	29	these	these	DET
gs-4062	134	30	enzymes	enzyme	NOUN
gs-4062	134	31	.	.	PUNCT
gs-4062	135	1	newer	new	ADJ
gs-4062	135	2	drugs	drug	NOUN
gs-4062	135	3	like	like	ADP
gs-4062	135	4	dolutegravir	dolutegravir	NOUN
gs-4062	135	5	and	and	CCONJ
gs-4062	135	6	bictegravir	bictegravir	PROPN
gs-4062	135	7	have	have	VERB
gs-4062	135	8	a	a	DET
gs-4062	135	9	lower	low	ADJ
gs-4062	135	10	ddi	ddi	ADJ
gs-4062	135	11	potential	potential	NOUN
gs-4062	135	12	than	than	ADP
gs-4062	135	13	older	old	ADJ
gs-4062	135	14	pis	pis	NOUN
gs-4062	135	15	and	and	CCONJ
gs-4062	135	16	nnrtis	nnrtis	NOUN
gs-4062	135	17	,	,	PUNCT
gs-4062	135	18	simplifying	simplify	VERB
gs-4062	135	19	co	co	NOUN
gs-4062	135	20	-	-	NOUN
gs-4062	135	21	administration	administration	NOUN
gs-4062	135	22	with	with	ADP
gs-4062	135	23	drugs	drug	NOUN
gs-4062	135	24	for	for	ADP
gs-4062	135	25	tuberculosis	tuberculosis	NOUN
gs-4062	135	26	,	,	PUNCT
gs-4062	135	27	hypertension	hypertension	NOUN
gs-4062	135	28	,	,	PUNCT
gs-4062	135	29	or	or	CCONJ
gs-4062	135	30	mental	mental	ADJ
gs-4062	135	31	health	health	NOUN
gs-4062	135	32	conditions	condition	NOUN
gs-4062	135	33	.	.	PUNCT
gs-4062	136	1	therapeutic	therapeutic	ADJ
gs-4062	136	2	drug	drug	NOUN
gs-4062	136	3	monitoring	monitoring	NOUN
gs-4062	136	4	(	(	PUNCT
gs-4062	136	5	tdm	tdm	NOUN
gs-4062	136	6	)	)	PUNCT
gs-4062	136	7	and	and	CCONJ
gs-4062	136	8	studies	study	NOUN
gs-4062	136	9	in	in	ADP
gs-4062	136	10	special	special	ADJ
gs-4062	136	11	populations	population	NOUN
gs-4062	136	12	(	(	PUNCT
gs-4062	136	13	hepatic	hepatic	ADJ
gs-4062	136	14	/	/	SYM
gs-4062	136	15	renal	renal	ADJ
gs-4062	136	16	impairment	impairment	NOUN
gs-4062	136	17	,	,	PUNCT
gs-4062	136	18	pregnant	pregnant	ADJ
gs-4062	136	19	women	woman	NOUN
gs-4062	136	20	)	)	PUNCT
gs-4062	136	21	are	be	AUX
gs-4062	136	22	essential	essential	ADJ
gs-4062	136	23	components	component	NOUN
gs-4062	136	24	of	of	ADP
gs-4062	136	25	this	this	DET
gs-4062	136	26	pharmacological	pharmacological	ADJ
gs-4062	136	27	discourse	discourse	NOUN
gs-4062	136	28	,	,	PUNCT
gs-4062	136	29	ensuring	ensure	VERB
gs-4062	136	30	safe	safe	ADJ
gs-4062	136	31	and	and	CCONJ
gs-4062	136	32	effective	effective	ADJ
gs-4062	136	33	use	use	NOUN
gs-4062	136	34	across	across	ADP
gs-4062	136	35	diverse	diverse	ADJ
gs-4062	136	36	patient	patient	ADJ
gs-4062	136	37	demographics	demographic	NOUN
gs-4062	136	38	.	.	PUNCT
gs-4062	137	1	the	the	DET
gs-4062	137	2	effects	effect	NOUN
gs-4062	137	3	of	of	ADP
gs-4062	137	4	new	new	ADJ
gs-4062	137	5	antiretrovirals	antiretroviral	NOUN
gs-4062	137	6	are	be	AUX
gs-4062	137	7	demonstrably	demonstrably	ADV
gs-4062	137	8	positive	positive	ADJ
gs-4062	137	9	,	,	PUNCT
gs-4062	137	10	driving	drive	VERB
gs-4062	137	11	the	the	DET
gs-4062	137	12	success	success	NOUN
gs-4062	137	13	of	of	ADP
gs-4062	137	14	modern	modern	ADJ
gs-4062	137	15	art	art	NOUN
gs-4062	137	16	.	.	PUNCT
gs-4062	138	1	the	the	DET
gs-4062	138	2	primary	primary	ADJ
gs-4062	138	3	effect	effect	NOUN
gs-4062	138	4	is	be	AUX
gs-4062	138	5	potent	potent	ADJ
gs-4062	138	6	and	and	CCONJ
gs-4062	138	7	durable	durable	ADJ
gs-4062	138	8	virological	virological	ADJ
gs-4062	138	9	suppression	suppression	NOUN
gs-4062	138	10	,	,	PUNCT
gs-4062	138	11	which	which	PRON
gs-4062	138	12	is	be	AUX
gs-4062	138	13	the	the	DET
gs-4062	138	14	direct	direct	ADJ
gs-4062	138	15	catalyst	catalyst	NOUN
gs-4062	138	16	for	for	ADP
gs-4062	138	17	the	the	DET
gs-4062	138	18	secondary	secondary	ADJ
gs-4062	138	19	effects	effect	NOUN
gs-4062	138	20	:	:	PUNCT
gs-4062	138	21	immune	immune	ADJ
gs-4062	138	22	reconstitution	reconstitution	NOUN
gs-4062	138	23	(	(	PUNCT
gs-4062	138	24	recovery	recovery	NOUN
gs-4062	138	25	of	of	ADP
gs-4062	138	26	cd4	cd4	PROPN
gs-4062	138	27	+	+	PROPN
gs-4062	138	28	t	t	PROPN
gs-4062	138	29	-	-	PUNCT
gs-4062	138	30	cell	cell	NOUN
gs-4062	138	31	counts	count	NOUN
gs-4062	138	32	)	)	PUNCT
gs-4062	138	33	and	and	CCONJ
gs-4062	138	34	a	a	DET
gs-4062	138	35	dramatic	dramatic	ADJ
gs-4062	138	36	reduction	reduction	NOUN
gs-4062	138	37	in	in	ADP
gs-4062	138	38	aids	aid	NOUN
gs-4062	138	39	-	-	PUNCT
gs-4062	138	40	defining	define	VERB
gs-4062	138	41	illnesses	illness	NOUN
gs-4062	138	42	and	and	CCONJ
gs-4062	138	43	mortality	mortality	NOUN
gs-4062	138	44	.	.	PUNCT
gs-4062	139	1	beyond	beyond	ADP
gs-4062	139	2	these	these	DET
gs-4062	139	3	fundamental	fundamental	ADJ
gs-4062	139	4	outcomes	outcome	NOUN
gs-4062	139	5	,	,	PUNCT
gs-4062	139	6	newer	new	ADJ
gs-4062	139	7	agents	agent	NOUN
gs-4062	139	8	contribute	contribute	VERB
gs-4062	139	9	to	to	ADP
gs-4062	139	10	significant	significant	ADJ
gs-4062	139	11	qualitative	qualitative	ADJ
gs-4062	139	12	improvements	improvement	NOUN
gs-4062	139	13	in	in	ADP
gs-4062	139	14	patient	patient	ADJ
gs-4062	139	15	lives	life	NOUN
gs-4062	139	16	.	.	PUNCT
gs-4062	140	1	simplified	simplified	ADJ
gs-4062	140	2	,	,	PUNCT
gs-4062	140	3	well	well	ADV
gs-4062	140	4	-	-	PUNCT
gs-4062	140	5	tolerated	tolerate	VERB
gs-4062	140	6	regimens	regimen	NOUN
gs-4062	140	7	reduce	reduce	VERB
gs-4062	140	8	pill	pill	NOUN
gs-4062	140	9	burden	burden	NOUN
gs-4062	140	10	and	and	CCONJ
gs-4062	140	11	treatment	treatment	NOUN
gs-4062	140	12	fatigue	fatigue	NOUN
gs-4062	140	13	.	.	PUNCT
gs-4062	141	1	the	the	DET
gs-4062	141	2	improved	improve	VERB
gs-4062	141	3	metabolic	metabolic	NOUN
gs-4062	141	4	profiles	profile	NOUN
gs-4062	141	5	lessen	lessen	VERB
gs-4062	141	6	the	the	DET
gs-4062	141	7	risk	risk	NOUN
gs-4062	141	8	of	of	ADP
gs-4062	141	9	non	non	ADJ
gs-4062	141	10	-	-	ADJ
gs-4062	141	11	aids	aids	ADJ
gs-4062	141	12	-	-	PUNCT
gs-4062	141	13	defining	define	VERB
gs-4062	141	14	comorbidities	comorbiditie	NOUN
gs-4062	141	15	such	such	ADJ
gs-4062	141	16	as	as	ADP
gs-4062	141	17	cardiovascular	cardiovascular	ADJ
gs-4062	141	18	,	,	PUNCT
gs-4062	141	19	renal	renal	ADJ
gs-4062	141	20	,	,	PUNCT
gs-4062	141	21	and	and	CCONJ
gs-4062	141	22	bone	bone	NOUN
gs-4062	141	23	diseases	disease	NOUN
gs-4062	141	24	,	,	PUNCT
gs-4062	141	25	which	which	PRON
gs-4062	141	26	now	now	ADV
gs-4062	141	27	represent	represent	VERB
gs-4062	141	28	a	a	DET
gs-4062	141	29	major	major	ADJ
gs-4062	141	30	focus	focus	NOUN
gs-4062	141	31	of	of	ADP
gs-4062	141	32	long	long	ADJ
gs-4062	141	33	-	-	PUNCT
gs-4062	141	34	term	term	NOUN
gs-4062	141	35	care	care	NOUN
gs-4062	141	36	.	.	PUNCT
gs-4062	142	1	perhaps	perhaps	ADV
gs-4062	142	2	one	one	NUM
gs-4062	142	3	of	of	ADP
gs-4062	142	4	the	the	DET
gs-4062	142	5	most	most	ADV
gs-4062	142	6	profound	profound	ADJ
gs-4062	142	7	public	public	ADJ
gs-4062	142	8	health	health	NOUN
gs-4062	142	9	effects	effect	NOUN
gs-4062	142	10	facilitated	facilitate	VERB
gs-4062	142	11	by	by	ADP
gs-4062	142	12	effective	effective	ADJ
gs-4062	142	13	art	art	NOUN
gs-4062	142	14	,	,	PUNCT
gs-4062	142	15	including	include	VERB
gs-4062	142	16	modern	modern	ADJ
gs-4062	142	17	regimens	regimen	NOUN
gs-4062	142	18	,	,	PUNCT
gs-4062	142	19	is	be	AUX
gs-4062	142	20	the	the	DET
gs-4062	142	21	concept	concept	NOUN
gs-4062	142	22	of	of	ADP
gs-4062	142	23	undetectable	undetectable	NOUN
gs-4062	142	24	=	=	SYM
gs-4062	142	25	untransmittable	untransmittable	ADJ
gs-4062	142	26	(	(	PUNCT
gs-4062	142	27	u	u	NOUN
gs-4062	142	28	=	=	NOUN
gs-4062	142	29	u	u	NOUN
gs-4062	142	30	)	)	PUNCT
gs-4062	142	31	.	.	PUNCT
gs-4062	143	1	a	a	DET
gs-4062	143	2	person	person	NOUN
gs-4062	143	3	with	with	ADP
gs-4062	143	4	a	a	DET
gs-4062	143	5	durably	durably	ADV
gs-4062	143	6	undetectable	undetectable	ADJ
gs-4062	143	7	viral	viral	ADJ
gs-4062	143	8	load	load	NOUN
gs-4062	143	9	can	can	AUX
gs-4062	143	10	not	not	PART
gs-4062	143	11	sexually	sexually	ADV
gs-4062	143	12	transmit	transmit	VERB
gs-4062	143	13	hiv	hiv	PROPN
gs-4062	143	14	to	to	ADP
gs-4062	143	15	their	their	PRON
gs-4062	143	16	partners	partner	NOUN
gs-4062	143	17	,	,	PUNCT
gs-4062	143	18	a	a	DET
gs-4062	143	19	fact	fact	NOUN
gs-4062	143	20	that	that	PRON
gs-4062	143	21	is	be	AUX
gs-4062	143	22	powerful	powerful	ADJ
gs-4062	143	23	in	in	ADP
gs-4062	143	24	dismantling	dismantle	VERB
gs-4062	143	25	stigma	stigma	NOUN
gs-4062	143	26	and	and	CCONJ
gs-4062	143	27	revolutionizing	revolutionize	VERB
gs-4062	143	28	hiv	hiv	PROPN
gs-4062	143	29	prevention	prevention	NOUN
gs-4062	143	30	strategies	strategy	NOUN
gs-4062	143	31	.	.	PUNCT
gs-4062	144	1	despite	despite	SCONJ
gs-4062	144	2	their	their	PRON
gs-4062	144	3	advanced	advanced	ADJ
gs-4062	144	4	design	design	NOUN
gs-4062	144	5	,	,	PUNCT
gs-4062	144	6	new	new	ADJ
gs-4062	144	7	antiretrovirals	antiretroviral	NOUN
gs-4062	144	8	are	be	AUX
gs-4062	144	9	not	not	PART
gs-4062	144	10	devoid	devoid	ADJ
gs-4062	144	11	of	of	ADP
gs-4062	144	12	toxicities	toxicity	NOUN
gs-4062	144	13	,	,	PUNCT
gs-4062	144	14	and	and	CCONJ
gs-4062	144	15	the	the	DET
gs-4062	144	16	characterization	characterization	NOUN
gs-4062	144	17	of	of	ADP
gs-4062	144	18	these	these	DET
gs-4062	144	19	adverse	adverse	ADJ
gs-4062	144	20	effects	effect	NOUN
gs-4062	144	21	is	be	AUX
gs-4062	144	22	a	a	DET
gs-4062	144	23	crucial	crucial	ADJ
gs-4062	144	24	and	and	CCONJ
gs-4062	144	25	evolving	evolve	VERB
gs-4062	144	26	part	part	NOUN
gs-4062	144	27	of	of	ADP
gs-4062	144	28	their	their	PRON
gs-4062	144	29	scientific	scientific	ADJ
gs-4062	144	30	narrative	narrative	NOUN
gs-4062	144	31	.	.	PUNCT
gs-4062	145	1	while	while	SCONJ
gs-4062	145	2	generally	generally	ADV
gs-4062	145	3	safer	safe	ADJ
gs-4062	145	4	,	,	PUNCT
gs-4062	145	5	each	each	DET
gs-4062	145	6	class	class	NOUN
gs-4062	145	7	and	and	CCONJ
gs-4062	145	8	individual	individual	ADJ
gs-4062	145	9	drug	drug	NOUN
gs-4062	145	10	carries	carry	VERB
gs-4062	145	11	a	a	DET
gs-4062	145	12	unique	unique	ADJ
gs-4062	145	13	toxicity	toxicity	NOUN
gs-4062	145	14	profile	profile	NOUN
gs-4062	145	15	that	that	PRON
gs-4062	145	16	must	must	AUX
gs-4062	145	17	be	be	AUX
gs-4062	145	18	meticulously	meticulously	ADV
gs-4062	145	19	characterized	characterize	VERB
gs-4062	145	20	in	in	ADP
gs-4062	145	21	large	large	ADJ
gs-4062	145	22	,	,	PUNCT
gs-4062	145	23	diverse	diverse	ADJ
gs-4062	145	24	clinical	clinical	ADJ
gs-4062	145	25	trials	trial	NOUN
gs-4062	145	26	and	and	CCONJ
gs-4062	145	27	post	post	ADJ
gs-4062	145	28	-	-	ADJ
gs-4062	145	29	marketing	marketing	ADJ
gs-4062	145	30	surveillance	surveillance	NOUN
gs-4062	145	31	.	.	PUNCT
gs-4062	146	1	for	for	ADP
gs-4062	146	2	the	the	DET
gs-4062	146	3	widely	widely	ADV
gs-4062	146	4	used	use	VERB
gs-4062	146	5	insti	insti	NOUN
gs-4062	146	6	class	class	NOUN
gs-4062	146	7	,	,	PUNCT
gs-4062	146	8	weight	weight	NOUN
gs-4062	146	9	gain	gain	NOUN
gs-4062	146	10	has	have	AUX
gs-4062	146	11	emerged	emerge	VERB
gs-4062	146	12	as	as	ADP
gs-4062	146	13	a	a	DET
gs-4062	146	14	significant	significant	ADJ
gs-4062	146	15	and	and	CCONJ
gs-4062	146	16	unexpected	unexpected	ADJ
gs-4062	146	17	class	class	NOUN
gs-4062	146	18	-	-	PUNCT
gs-4062	146	19	effect	effect	NOUN
gs-4062	146	20	concern	concern	NOUN
gs-4062	146	21	.	.	PUNCT
gs-4062	147	1	patients	patient	NOUN
gs-4062	147	2	,	,	PUNCT
gs-4062	147	3	particularly	particularly	ADV
gs-4062	147	4	women	woman	NOUN
gs-4062	147	5	of	of	ADP
gs-4062	147	6	african	african	ADJ
gs-4062	147	7	descent	descent	NOUN
gs-4062	147	8	,	,	PUNCT
gs-4062	147	9	initiating	initiate	VERB
gs-4062	147	10	dolutegravir	dolutegravir	NOUN
gs-4062	147	11	or	or	CCONJ
gs-4062	147	12	bictegravirbased	bictegravirbase	VERB
gs-4062	147	13	regimens	regimen	NOUN
gs-4062	147	14	have	have	AUX
gs-4062	147	15	shown	show	VERB
gs-4062	147	16	a	a	DET
gs-4062	147	17	greater	great	ADJ
gs-4062	147	18	propensity	propensity	NOUN
gs-4062	147	19	for	for	ADP
gs-4062	147	20	weight	weight	NOUN
gs-4062	147	21	gain	gain	NOUN
gs-4062	147	22	and	and	CCONJ
gs-4062	147	23	associated	associate	VERB
gs-4062	147	24	metabolic	metabolic	NOUN
gs-4062	147	25	changes	change	NOUN
gs-4062	147	26	compared	compare	VERB
gs-4062	147	27	to	to	ADP
gs-4062	147	28	those	those	PRON
gs-4062	147	29	on	on	ADP
gs-4062	147	30	older	old	ADJ
gs-4062	147	31	regimens	regimen	NOUN
gs-4062	147	32	.	.	PUNCT
gs-4062	148	1	the	the	DET
gs-4062	148	2	mechanisms	mechanism	NOUN
gs-4062	148	3	are	be	AUX
gs-4062	148	4	under	under	ADP
gs-4062	148	5	intense	intense	ADJ
gs-4062	148	6	investigation	investigation	NOUN
gs-4062	148	7	,	,	PUNCT
gs-4062	148	8	possibly	possibly	ADV
gs-4062	148	9	involving	involve	VERB
gs-4062	148	10	effects	effect	NOUN
gs-4062	148	11	on	on	ADP
gs-4062	148	12	melanocortin-4	melanocortin-4	NUM
gs-4062	148	13	receptors	receptor	NOUN
gs-4062	148	14	or	or	CCONJ
gs-4062	148	15	mitochondrial	mitochondrial	ADJ
gs-4062	148	16	function	function	NOUN
gs-4062	148	17	.	.	PUNCT
gs-4062	149	1	neuropsychiatric	neuropsychiatric	ADJ
gs-4062	149	2	effects	effect	NOUN
gs-4062	149	3	,	,	PUNCT
gs-4062	149	4	including	include	VERB
gs-4062	149	5	insomnia	insomnia	NOUN
gs-4062	149	6	,	,	PUNCT
gs-4062	149	7	anxiety	anxiety	NOUN
gs-4062	149	8	,	,	PUNCT
gs-4062	149	9	and	and	CCONJ
gs-4062	149	10	depression	depression	NOUN
gs-4062	149	11	,	,	PUNCT
gs-4062	149	12	were	be	AUX
gs-4062	149	13	initially	initially	ADV
gs-4062	149	14	noted	note	VERB
gs-4062	149	15	with	with	ADP
gs-4062	149	16	dolutegravir	dolutegravir	NOUN
gs-4062	149	17	,	,	PUNCT
gs-4062	149	18	though	though	SCONJ
gs-4062	149	19	longerterm	longerterm	NOUN
gs-4062	149	20	data	datum	NOUN
gs-4062	149	21	suggest	suggest	VERB
gs-4062	149	22	they	they	PRON
gs-4062	149	23	are	be	AUX
gs-4062	149	24	often	often	ADV
gs-4062	149	25	transient	transient	ADJ
gs-4062	149	26	and	and	CCONJ
gs-4062	149	27	less	less	ADV
gs-4062	149	28	common	common	ADJ
gs-4062	149	29	than	than	SCONJ
gs-4062	149	30	initially	initially	ADV
gs-4062	149	31	feared	fear	VERB
gs-4062	149	32	.	.	PUNCT
gs-4062	150	1	other	other	ADJ
gs-4062	150	2	toxicities	toxicity	NOUN
gs-4062	150	3	include	include	VERB
gs-4062	150	4	hypersensitivity	hypersensitivity	NOUN
gs-4062	150	5	reactions	reaction	NOUN
gs-4062	150	6	(	(	PUNCT
gs-4062	150	7	e.g.	e.g.	ADV
gs-4062	150	8	,	,	PUNCT
gs-4062	150	9	to	to	ADP
gs-4062	150	10	abacavir	abacavir	NOUN
gs-4062	150	11	,	,	PUNCT
gs-4062	150	12	though	though	SCONJ
gs-4062	150	13	not	not	PART
gs-4062	150	14	a	a	DET
gs-4062	150	15	new	new	ADJ
gs-4062	150	16	drug	drug	NOUN
gs-4062	150	17	,	,	PUNCT
gs-4062	150	18	its	its	PRON
gs-4062	150	19	pharmacogenetic	pharmacogenetic	ADJ
gs-4062	150	20	screening	screening	NOUN
gs-4062	150	21	remains	remain	VERB
gs-4062	150	22	a	a	DET
gs-4062	150	23	model	model	NOUN
gs-4062	150	24	for	for	ADP
gs-4062	150	25	safety	safety	NOUN
gs-4062	150	26	)	)	PUNCT
gs-4062	150	27	,	,	PUNCT
gs-4062	150	28	gastrointestinal	gastrointestinal	ADJ
gs-4062	150	29	disturbances	disturbance	NOUN
gs-4062	150	30	,	,	PUNCT
gs-4062	150	31	and	and	CCONJ
gs-4062	150	32	potential	potential	ADJ
gs-4062	150	33	renal	renal	ADJ
gs-4062	150	34	effects	effect	NOUN
gs-4062	150	35	(	(	PUNCT
gs-4062	150	36	though	though	SCONJ
gs-4062	150	37	significantly	significantly	ADV
gs-4062	150	38	reduced	reduce	VERB
gs-4062	150	39	with	with	ADP
gs-4062	150	40	taf	taf	PROPN
gs-4062	150	41	)	)	PUNCT
gs-4062	150	42	.	.	PUNCT
gs-4062	151	1	the	the	DET
gs-4062	151	2	discussion	discussion	NOUN
gs-4062	151	3	around	around	ADP
gs-4062	151	4	toxicities	toxicity	NOUN
gs-4062	151	5	is	be	AUX
gs-4062	151	6	a	a	DET
gs-4062	151	7	testament	testament	NOUN
gs-4062	151	8	to	to	ADP
gs-4062	151	9	the	the	DET
gs-4062	151	10	rigor	rigor	NOUN
gs-4062	151	11	of	of	ADP
gs-4062	151	12	pharmacovigilance	pharmacovigilance	NOUN
gs-4062	151	13	,	,	PUNCT
gs-4062	151	14	balancing	balance	VERB
gs-4062	151	15	overwhelming	overwhelming	ADJ
gs-4062	151	16	efficacy	efficacy	NOUN
gs-4062	151	17	with	with	ADP
gs-4062	151	18	the	the	DET
gs-4062	151	19	management	management	NOUN
gs-4062	151	20	of	of	ADP
gs-4062	151	21	often	often	ADV
gs-4062	151	22	manageable	manageable	ADJ
gs-4062	151	23	side	side	NOUN
gs-4062	151	24	effects	effect	NOUN
gs-4062	151	25	to	to	PART
gs-4062	151	26	ensure	ensure	VERB
gs-4062	151	27	long	long	ADJ
gs-4062	151	28	-	-	PUNCT
gs-4062	151	29	term	term	NOUN
gs-4062	151	30	health	health	NOUN
gs-4062	151	31	and	and	CCONJ
gs-4062	151	32	quality	quality	NOUN
gs-4062	151	33	of	of	ADP
gs-4062	151	34	life	life	NOUN
gs-4062	151	35	.	.	PUNCT
gs-4062	152	1	the	the	DET
gs-4062	152	2	scientific	scientific	ADJ
gs-4062	152	3	discussion	discussion	NOUN
gs-4062	152	4	surrounding	surround	VERB
gs-4062	152	5	new	new	ADJ
gs-4062	152	6	antiretroviral	antiretroviral	ADJ
gs-4062	152	7	medicines	medicine	NOUN
gs-4062	152	8	is	be	AUX
gs-4062	152	9	a	a	DET
gs-4062	152	10	comprehensive	comprehensive	ADJ
gs-4062	152	11	,	,	PUNCT
gs-4062	152	12	iterative	iterative	NOUN
gs-4062	152	13	,	,	PUNCT
gs-4062	152	14	and	and	CCONJ
gs-4062	152	15	indispensable	indispensable	ADJ
gs-4062	152	16	process	process	NOUN
gs-4062	152	17	.	.	PUNCT
gs-4062	153	1	it	it	PRON
gs-4062	153	2	is	be	AUX
gs-4062	153	3	a	a	DET
gs-4062	153	4	multidisciplinary	multidisciplinary	ADJ
gs-4062	153	5	dialogue	dialogue	NOUN
gs-4062	153	6	that	that	PRON
gs-4062	153	7	systematically	systematically	ADV
gs-4062	153	8	evaluates	evaluate	VERB
gs-4062	153	9	georgian	georgian	NOUN
gs-4062	153	10	scientists/	scientists/	NUM
gs-4062	153	11	.	.	PUNCT
gs-4062	154	1	7	7	NUM
gs-4062	154	2	n	n	PRON
gs-4062	154	3	3	3	NUM
gs-4062	154	4	,	,	PUNCT
gs-4062	154	5	2025	2025	NUM
gs-4062	154	6	529	529	NUM
gs-4062	154	7	every	every	DET
gs-4062	154	8	facet	facet	NOUN
gs-4062	154	9	of	of	ADP
gs-4062	154	10	these	these	DET
gs-4062	154	11	compounds	compound	NOUN
gs-4062	154	12	,	,	PUNCT
gs-4062	154	13	from	from	ADP
gs-4062	154	14	their	their	PRON
gs-4062	154	15	molecular	molecular	ADJ
gs-4062	154	16	classification	classification	NOUN
gs-4062	154	17	and	and	CCONJ
gs-4062	154	18	novel	novel	ADJ
gs-4062	154	19	mechanisms	mechanism	NOUN
gs-4062	154	20	to	to	ADP
gs-4062	154	21	their	their	PRON
gs-4062	154	22	real	real	ADJ
gs-4062	154	23	-	-	PUNCT
gs-4062	154	24	world	world	NOUN
gs-4062	154	25	clinical	clinical	ADJ
gs-4062	154	26	utility	utility	NOUN
gs-4062	154	27	and	and	CCONJ
gs-4062	154	28	long	long	ADJ
gs-4062	154	29	-	-	PUNCT
gs-4062	154	30	term	term	NOUN
gs-4062	154	31	safety	safety	NOUN
gs-4062	154	32	.	.	PUNCT
gs-4062	155	1	this	this	DET
gs-4062	155	2	discourse	discourse	NOUN
gs-4062	155	3	has	have	AUX
gs-4062	155	4	propelled	propel	VERB
gs-4062	155	5	the	the	DET
gs-4062	155	6	field	field	NOUN
gs-4062	155	7	from	from	ADP
gs-4062	155	8	toxic	toxic	ADJ
gs-4062	155	9	,	,	PUNCT
gs-4062	155	10	cumbersome	cumbersome	ADJ
gs-4062	155	11	regimens	regimen	NOUN
gs-4062	155	12	to	to	ADP
gs-4062	155	13	highly	highly	ADV
gs-4062	155	14	effective	effective	ADJ
gs-4062	155	15	,	,	PUNCT
gs-4062	155	16	well	well	ADV
gs-4062	155	17	-	-	PUNCT
gs-4062	155	18	tolerated	tolerate	VERB
gs-4062	155	19	,	,	PUNCT
gs-4062	155	20	and	and	CCONJ
gs-4062	155	21	user	user	NOUN
gs-4062	155	22	-	-	PUNCT
gs-4062	155	23	friendly	friendly	ADJ
gs-4062	155	24	therapies	therapy	NOUN
gs-4062	155	25	.	.	PUNCT
gs-4062	156	1	the	the	DET
gs-4062	156	2	manifestation	manifestation	NOUN
gs-4062	156	3	of	of	ADP
gs-4062	156	4	this	this	DET
gs-4062	156	5	discussion	discussion	NOUN
gs-4062	156	6	is	be	AUX
gs-4062	156	7	evident	evident	ADJ
gs-4062	156	8	in	in	ADP
gs-4062	156	9	treatment	treatment	NOUN
gs-4062	156	10	guidelines	guideline	NOUN
gs-4062	156	11	that	that	PRON
gs-4062	156	12	are	be	AUX
gs-4062	156	13	frequently	frequently	ADV
gs-4062	156	14	updated	update	VERB
gs-4062	156	15	based	base	VERB
gs-4062	156	16	on	on	ADP
gs-4062	156	17	emerging	emerge	VERB
gs-4062	156	18	evidence	evidence	NOUN
gs-4062	156	19	,	,	PUNCT
gs-4062	156	20	ensuring	ensure	VERB
gs-4062	156	21	that	that	SCONJ
gs-4062	156	22	clinical	clinical	ADJ
gs-4062	156	23	practice	practice	NOUN
gs-4062	156	24	remains	remain	VERB
gs-4062	156	25	at	at	ADP
gs-4062	156	26	the	the	DET
gs-4062	156	27	cutting	cut	VERB
gs-4062	156	28	edge	edge	NOUN
gs-4062	156	29	of	of	ADP
gs-4062	156	30	scientific	scientific	ADJ
gs-4062	156	31	progress	progress	NOUN
gs-4062	156	32	.	.	PUNCT
gs-4062	157	1	as	as	SCONJ
gs-4062	157	2	research	research	NOUN
gs-4062	157	3	continues	continue	VERB
gs-4062	157	4	to	to	PART
gs-4062	157	5	push	push	VERB
gs-4062	157	6	boundaries	boundary	NOUN
gs-4062	157	7	with	with	ADP
gs-4062	157	8	long	long	ADV
gs-4062	157	9	-	-	PUNCT
gs-4062	157	10	acting	act	VERB
gs-4062	157	11	agents	agent	NOUN
gs-4062	157	12	,	,	PUNCT
gs-4062	157	13	broadly	broadly	ADV
gs-4062	157	14	neutralizing	neutralize	VERB
gs-4062	157	15	antibodies	antibody	NOUN
gs-4062	157	16	,	,	PUNCT
gs-4062	157	17	and	and	CCONJ
gs-4062	157	18	pursuit	pursuit	NOUN
gs-4062	157	19	of	of	ADP
gs-4062	157	20	a	a	DET
gs-4062	157	21	cure	cure	NOUN
gs-4062	157	22	,	,	PUNCT
gs-4062	157	23	the	the	DET
gs-4062	157	24	rigorous	rigorous	ADJ
gs-4062	157	25	framework	framework	NOUN
gs-4062	157	26	for	for	ADP
gs-4062	157	27	scientific	scientific	ADJ
gs-4062	157	28	discussion	discussion	NOUN
gs-4062	157	29	—	—	PUNCT
gs-4062	157	30	encompassing	encompass	VERB
gs-4062	157	31	classification	classification	NOUN
gs-4062	157	32	,	,	PUNCT
gs-4062	157	33	clinical	clinical	ADJ
gs-4062	157	34	use	use	NOUN
gs-4062	157	35	,	,	PUNCT
gs-4062	157	36	features	feature	NOUN
gs-4062	157	37	,	,	PUNCT
gs-4062	157	38	mechanism	mechanism	NOUN
gs-4062	157	39	,	,	PUNCT
gs-4062	157	40	pharmacology	pharmacology	NOUN
gs-4062	157	41	,	,	PUNCT
gs-4062	157	42	effects	effect	NOUN
gs-4062	157	43	,	,	PUNCT
gs-4062	157	44	and	and	CCONJ
gs-4062	157	45	toxicities	toxicity	NOUN
gs-4062	157	46	—	—	PUNCT
gs-4062	157	47	will	will	AUX
gs-4062	157	48	remain	remain	VERB
gs-4062	157	49	the	the	DET
gs-4062	157	50	bedrock	bedrock	NOUN
gs-4062	157	51	upon	upon	SCONJ
gs-4062	157	52	which	which	PRON
gs-4062	157	53	future	future	ADJ
gs-4062	157	54	breakthroughs	breakthrough	NOUN
gs-4062	157	55	are	be	AUX
gs-4062	157	56	evaluated	evaluate	VERB
gs-4062	157	57	and	and	CCONJ
gs-4062	157	58	integrated	integrate	VERB
gs-4062	157	59	,	,	PUNCT
gs-4062	157	60	ultimately	ultimately	ADV
gs-4062	157	61	improving	improve	VERB
gs-4062	157	62	the	the	DET
gs-4062	157	63	lives	life	NOUN
gs-4062	157	64	of	of	ADP
gs-4062	157	65	millions	million	NOUN
gs-4062	157	66	living	live	VERB
gs-4062	157	67	with	with	ADP
gs-4062	157	68	hiv	hiv	PROPN
gs-4062	157	69	worldwide	worldwide	ADV
gs-4062	157	70	.	.	PUNCT
gs-4062	158	1	background	background	NOUN
gs-4062	158	2	the	the	DET
gs-4062	158	3	narrative	narrative	NOUN
gs-4062	158	4	of	of	ADP
gs-4062	158	5	the	the	DET
gs-4062	158	6	human	human	ADJ
gs-4062	158	7	immunodeficiency	immunodeficiency	NOUN
gs-4062	158	8	virus	virus	NOUN
gs-4062	158	9	(	(	PUNCT
gs-4062	158	10	hiv	hiv	PROPN
gs-4062	158	11	)	)	PUNCT
gs-4062	158	12	and	and	CCONJ
gs-4062	158	13	the	the	DET
gs-4062	158	14	subsequent	subsequent	ADJ
gs-4062	158	15	global	global	ADJ
gs-4062	158	16	acquired	acquire	VERB
gs-4062	158	17	immunodeficiency	immunodeficiency	NOUN
gs-4062	158	18	syndrome	syndrome	NOUN
gs-4062	158	19	(	(	PUNCT
gs-4062	158	20	aids	aids	PROPN
gs-4062	158	21	)	)	PUNCT
gs-4062	158	22	pandemic	pandemic	NOUN
gs-4062	158	23	is	be	AUX
gs-4062	158	24	a	a	DET
gs-4062	158	25	profound	profound	ADJ
gs-4062	158	26	saga	saga	NOUN
gs-4062	158	27	of	of	ADP
gs-4062	158	28	scientific	scientific	ADJ
gs-4062	158	29	discovery	discovery	NOUN
gs-4062	158	30	,	,	PUNCT
gs-4062	158	31	medical	medical	ADJ
gs-4062	158	32	innovation	innovation	NOUN
gs-4062	158	33	,	,	PUNCT
gs-4062	158	34	societal	societal	ADJ
gs-4062	158	35	struggle	struggle	NOUN
gs-4062	158	36	,	,	PUNCT
gs-4062	158	37	and	and	CCONJ
gs-4062	158	38	human	human	ADJ
gs-4062	158	39	resilience	resilience	NOUN
gs-4062	158	40	.	.	PUNCT
gs-4062	159	1	to	to	PART
gs-4062	159	2	fully	fully	ADV
gs-4062	159	3	appreciate	appreciate	VERB
gs-4062	159	4	the	the	DET
gs-4062	159	5	revolutionary	revolutionary	ADJ
gs-4062	159	6	impact	impact	NOUN
gs-4062	159	7	of	of	ADP
gs-4062	159	8	the	the	DET
gs-4062	159	9	newest	new	ADJ
gs-4062	159	10	antiretroviral	antiretroviral	ADJ
gs-4062	159	11	agents	agent	NOUN
gs-4062	159	12	,	,	PUNCT
gs-4062	159	13	one	one	PRON
gs-4062	159	14	must	must	AUX
gs-4062	159	15	first	first	ADV
gs-4062	159	16	understand	understand	VERB
gs-4062	159	17	the	the	DET
gs-4062	159	18	deep	deep	ADJ
gs-4062	159	19	and	and	CCONJ
gs-4062	159	20	complex	complex	ADJ
gs-4062	159	21	historical	historical	ADJ
gs-4062	159	22	,	,	PUNCT
gs-4062	159	23	virological	virological	ADJ
gs-4062	159	24	,	,	PUNCT
gs-4062	159	25	and	and	CCONJ
gs-4062	159	26	therapeutic	therapeutic	ADJ
gs-4062	159	27	context	context	NOUN
gs-4062	159	28	from	from	ADP
gs-4062	159	29	which	which	PRON
gs-4062	159	30	they	they	PRON
gs-4062	159	31	emerged	emerge	VERB
gs-4062	159	32	.	.	PUNCT
gs-4062	160	1	this	this	DET
gs-4062	160	2	background	background	NOUN
gs-4062	160	3	traces	trace	VERB
gs-4062	160	4	the	the	DET
gs-4062	160	5	arduous	arduous	ADJ
gs-4062	160	6	journey	journey	NOUN
gs-4062	160	7	from	from	ADP
gs-4062	160	8	the	the	DET
gs-4062	160	9	initial	initial	ADJ
gs-4062	160	10	terrifying	terrifying	ADJ
gs-4062	160	11	emergence	emergence	NOUN
gs-4062	160	12	of	of	ADP
gs-4062	160	13	a	a	DET
gs-4062	160	14	mysterious	mysterious	ADJ
gs-4062	160	15	fatal	fatal	ADJ
gs-4062	160	16	illness	illness	NOUN
gs-4062	160	17	to	to	ADP
gs-4062	160	18	the	the	DET
gs-4062	160	19	current	current	ADJ
gs-4062	160	20	era	era	NOUN
gs-4062	160	21	where	where	SCONJ
gs-4062	160	22	hiv	hiv	PROPN
gs-4062	160	23	is	be	AUX
gs-4062	160	24	a	a	DET
gs-4062	160	25	manageable	manageable	ADJ
gs-4062	160	26	chronic	chronic	ADJ
gs-4062	160	27	condition	condition	NOUN
gs-4062	160	28	,	,	PUNCT
gs-4062	160	29	setting	set	VERB
gs-4062	160	30	the	the	DET
gs-4062	160	31	stage	stage	NOUN
gs-4062	160	32	for	for	ADP
gs-4062	160	33	the	the	DET
gs-4062	160	34	paradigm	paradigm	NOUN
gs-4062	160	35	-	-	PUNCT
gs-4062	160	36	shifting	shift	VERB
gs-4062	160	37	advancements	advancement	NOUN
gs-4062	160	38	that	that	PRON
gs-4062	160	39	define	define	VERB
gs-4062	160	40	the	the	DET
gs-4062	160	41	contemporary	contemporary	ADJ
gs-4062	160	42	therapeutic	therapeutic	ADJ
gs-4062	160	43	landscape	landscape	NOUN
gs-4062	160	44	.	.	PUNCT
gs-4062	161	1	it	it	PRON
gs-4062	161	2	is	be	AUX
gs-4062	161	3	a	a	DET
gs-4062	161	4	story	story	NOUN
gs-4062	161	5	of	of	ADP
gs-4062	161	6	incremental	incremental	ADJ
gs-4062	161	7	progress	progress	NOUN
gs-4062	161	8	,	,	PUNCT
gs-4062	161	9	punctuated	punctuate	VERB
gs-4062	161	10	by	by	ADP
gs-4062	161	11	moments	moment	NOUN
gs-4062	161	12	of	of	ADP
gs-4062	161	13	breathtaking	breathtaking	ADJ
gs-4062	161	14	breakthrough	breakthrough	NOUN
gs-4062	161	15	,	,	PUNCT
gs-4062	161	16	each	each	DET
gs-4062	161	17	building	building	NOUN
gs-4062	161	18	upon	upon	SCONJ
gs-4062	161	19	the	the	DET
gs-4062	161	20	last	last	ADJ
gs-4062	161	21	in	in	ADP
gs-4062	161	22	the	the	DET
gs-4062	161	23	relentless	relentless	ADJ
gs-4062	161	24	pursuit	pursuit	NOUN
gs-4062	161	25	of	of	ADP
gs-4062	161	26	overcoming	overcome	VERB
gs-4062	161	27	one	one	NUM
gs-4062	161	28	of	of	ADP
gs-4062	161	29	history	history	NOUN
gs-4062	161	30	's	's	PART
gs-4062	161	31	most	most	ADV
gs-4062	161	32	formidable	formidable	ADJ
gs-4062	161	33	pathogens	pathogen	NOUN
gs-4062	161	34	.	.	PUNCT
gs-4062	162	1	the	the	DET
gs-4062	162	2	modern	modern	ADJ
gs-4062	162	3	history	history	NOUN
gs-4062	162	4	of	of	ADP
gs-4062	162	5	hiv	hiv	PROPN
gs-4062	162	6	begins	begin	VERB
gs-4062	162	7	in	in	ADP
gs-4062	162	8	the	the	DET
gs-4062	162	9	early	early	ADJ
gs-4062	162	10	1980s	1980	NOUN
gs-4062	162	11	,	,	PUNCT
gs-4062	162	12	when	when	SCONJ
gs-4062	162	13	clusters	cluster	NOUN
gs-4062	162	14	of	of	ADP
gs-4062	162	15	previously	previously	ADV
gs-4062	162	16	rare	rare	ADJ
gs-4062	162	17	opportunistic	opportunistic	ADJ
gs-4062	162	18	infections	infection	NOUN
gs-4062	162	19	—	—	PUNCT
gs-4062	162	20	such	such	ADJ
gs-4062	162	21	as	as	ADP
gs-4062	162	22	pneumocystis	pneumocystis	ADJ
gs-4062	162	23	jirovecii	jirovecii	ADJ
gs-4062	162	24	pneumonia	pneumonia	NOUN
gs-4062	162	25	and	and	CCONJ
gs-4062	162	26	kaposi	kaposi	PROPN
gs-4062	162	27	's	's	PART
gs-4062	162	28	sarcoma	sarcoma	NOUN
gs-4062	162	29	—	—	PUNCT
gs-4062	162	30	began	begin	VERB
gs-4062	162	31	appearing	appear	VERB
gs-4062	162	32	in	in	ADP
gs-4062	162	33	previously	previously	ADV
gs-4062	162	34	healthy	healthy	ADJ
gs-4062	162	35	gay	gay	ADJ
gs-4062	162	36	men	man	NOUN
gs-4062	162	37	in	in	ADP
gs-4062	162	38	urban	urban	ADJ
gs-4062	162	39	centers	center	NOUN
gs-4062	162	40	in	in	ADP
gs-4062	162	41	the	the	DET
gs-4062	162	42	united	united	PROPN
gs-4062	162	43	states	states	PROPN
gs-4062	162	44	.	.	PUNCT
gs-4062	163	1	the	the	DET
gs-4062	163	2	medical	medical	ADJ
gs-4062	163	3	community	community	NOUN
gs-4062	163	4	was	be	AUX
gs-4062	163	5	initially	initially	ADV
gs-4062	163	6	baffled	baffle	VERB
gs-4062	163	7	by	by	ADP
gs-4062	163	8	this	this	DET
gs-4062	163	9	new	new	ADJ
gs-4062	163	10	syndrome	syndrome	NOUN
gs-4062	163	11	,	,	PUNCT
gs-4062	163	12	which	which	PRON
gs-4062	163	13	seemed	seem	VERB
gs-4062	163	14	to	to	PART
gs-4062	163	15	completely	completely	ADV
gs-4062	163	16	dismantle	dismantle	VERB
gs-4062	163	17	the	the	DET
gs-4062	163	18	human	human	ADJ
gs-4062	163	19	immune	immune	ADJ
gs-4062	163	20	system	system	NOUN
gs-4062	163	21	.	.	PUNCT
gs-4062	164	1	it	it	PRON
gs-4062	164	2	was	be	AUX
gs-4062	164	3	initially	initially	ADV
gs-4062	164	4	termed	term	VERB
gs-4062	164	5	grid	grid	NOUN
gs-4062	164	6	(	(	PUNCT
gs-4062	164	7	gay	gay	NOUN
gs-4062	164	8	-	-	PUNCT
gs-4062	164	9	related	relate	VERB
gs-4062	164	10	immune	immune	ADJ
gs-4062	164	11	deficiency	deficiency	NOUN
gs-4062	164	12	)	)	PUNCT
gs-4062	164	13	before	before	ADP
gs-4062	164	14	being	be	AUX
gs-4062	164	15	renamed	rename	VERB
gs-4062	164	16	aids	aid	NOUN
gs-4062	164	17	in	in	ADP
gs-4062	164	18	1982	1982	NUM
gs-4062	164	19	as	as	SCONJ
gs-4062	164	20	it	it	PRON
gs-4062	164	21	became	become	VERB
gs-4062	164	22	clear	clear	ADJ
gs-4062	164	23	it	it	PRON
gs-4062	164	24	affected	affect	VERB
gs-4062	164	25	other	other	ADJ
gs-4062	164	26	populations	population	NOUN
gs-4062	164	27	,	,	PUNCT
gs-4062	164	28	including	include	VERB
gs-4062	164	29	hemophiliacs	hemophiliac	NOUN
gs-4062	164	30	,	,	PUNCT
gs-4062	164	31	recipients	recipient	NOUN
gs-4062	164	32	of	of	ADP
gs-4062	164	33	blood	blood	NOUN
gs-4062	164	34	transfusions	transfusion	NOUN
gs-4062	164	35	,	,	PUNCT
gs-4062	164	36	and	and	CCONJ
gs-4062	164	37	injection	injection	NOUN
gs-4062	164	38	drug	drug	NOUN
gs-4062	164	39	users	user	NOUN
gs-4062	164	40	.	.	PUNCT
gs-4062	165	1	the	the	DET
gs-4062	165	2	fear	fear	NOUN
gs-4062	165	3	and	and	CCONJ
gs-4062	165	4	stigma	stigma	NOUN
gs-4062	165	5	were	be	AUX
gs-4062	165	6	immediate	immediate	ADJ
gs-4062	165	7	and	and	CCONJ
gs-4062	165	8	pervasive	pervasive	ADJ
gs-4062	165	9	,	,	PUNCT
gs-4062	165	10	fueled	fuel	VERB
gs-4062	165	11	by	by	ADP
gs-4062	165	12	misinformation	misinformation	NOUN
gs-4062	165	13	and	and	CCONJ
gs-4062	165	14	a	a	DET
gs-4062	165	15	lack	lack	NOUN
gs-4062	165	16	of	of	ADP
gs-4062	165	17	understanding	understanding	NOUN
gs-4062	165	18	about	about	ADP
gs-4062	165	19	the	the	DET
gs-4062	165	20	disease	disease	NOUN
gs-4062	165	21	's	's	PART
gs-4062	165	22	transmission	transmission	NOUN
gs-4062	165	23	.	.	PUNCT
gs-4062	166	1	the	the	DET
gs-4062	166	2	identification	identification	NOUN
gs-4062	166	3	of	of	ADP
gs-4062	166	4	the	the	DET
gs-4062	166	5	causative	causative	ADJ
gs-4062	166	6	agent	agent	NOUN
gs-4062	166	7	,	,	PUNCT
gs-4062	166	8	a	a	DET
gs-4062	166	9	retrovirus	retrovirus	NOUN
gs-4062	166	10	first	first	ADV
gs-4062	166	11	named	name	VERB
gs-4062	166	12	htlv	htlv	PROPN
gs-4062	166	13	-	-	PUNCT
gs-4062	166	14	iii	iii	PROPN
gs-4062	166	15	and	and	CCONJ
gs-4062	166	16	lav	lav	NOUN
gs-4062	166	17	by	by	ADP
gs-4062	166	18	competing	compete	VERB
gs-4062	166	19	research	research	NOUN
gs-4062	166	20	teams	team	NOUN
gs-4062	166	21	,	,	PUNCT
gs-4062	166	22	was	be	AUX
gs-4062	166	23	a	a	DET
gs-4062	166	24	pivotal	pivotal	ADJ
gs-4062	166	25	first	first	ADJ
gs-4062	166	26	step	step	NOUN
gs-4062	166	27	.	.	PUNCT
gs-4062	167	1	the	the	DET
gs-4062	167	2	eventual	eventual	ADJ
gs-4062	167	3	resolution	resolution	NOUN
gs-4062	167	4	of	of	ADP
gs-4062	167	5	the	the	DET
gs-4062	167	6	scientific	scientific	ADJ
gs-4062	167	7	dispute	dispute	NOUN
gs-4062	167	8	and	and	CCONJ
gs-4062	167	9	its	its	PRON
gs-4062	167	10	re	re	NOUN
gs-4062	167	11	-	-	NOUN
gs-4062	167	12	designation	designation	NOUN
gs-4062	167	13	as	as	ADP
gs-4062	167	14	human	human	ADJ
gs-4062	167	15	immunodeficiency	immunodeficiency	NOUN
gs-4062	167	16	virus	virus	NOUN
gs-4062	167	17	in	in	ADP
gs-4062	167	18	1986	1986	NUM
gs-4062	167	19	allowed	allow	VERB
gs-4062	167	20	the	the	DET
gs-4062	167	21	global	global	ADJ
gs-4062	167	22	scientific	scientific	ADJ
gs-4062	167	23	community	community	NOUN
gs-4062	167	24	to	to	PART
gs-4062	167	25	unite	unite	VERB
gs-4062	167	26	around	around	ADP
gs-4062	167	27	a	a	DET
gs-4062	167	28	common	common	ADJ
gs-4062	167	29	target	target	NOUN
gs-4062	167	30	.	.	PUNCT
gs-4062	168	1	understanding	understand	VERB
gs-4062	168	2	the	the	DET
gs-4062	168	3	virus	virus	NOUN
gs-4062	168	4	's	's	PART
gs-4062	168	5	structure	structure	NOUN
gs-4062	168	6	and	and	CCONJ
gs-4062	168	7	replication	replication	NOUN
gs-4062	168	8	cycle	cycle	NOUN
gs-4062	168	9	was	be	AUX
gs-4062	168	10	the	the	DET
gs-4062	168	11	next	next	ADJ
gs-4062	168	12	critical	critical	ADJ
gs-4062	168	13	hurdle	hurdle	NOUN
gs-4062	168	14	.	.	PUNCT
gs-4062	169	1	hiv	hiv	PROPN
gs-4062	169	2	is	be	AUX
gs-4062	169	3	a	a	DET
gs-4062	169	4	lentivirus	lentivirus	NOUN
gs-4062	169	5	,	,	PUNCT
gs-4062	169	6	a	a	DET
gs-4062	169	7	subgroup	subgroup	NOUN
gs-4062	169	8	of	of	ADP
gs-4062	169	9	retroviruses	retrovirus	NOUN
gs-4062	169	10	characterized	characterize	VERB
gs-4062	169	11	by	by	ADP
gs-4062	169	12	a	a	DET
gs-4062	169	13	long	long	ADJ
gs-4062	169	14	incubation	incubation	NOUN
gs-4062	169	15	period	period	NOUN
gs-4062	169	16	.	.	PUNCT
gs-4062	170	1	its	its	PRON
gs-4062	170	2	structure	structure	NOUN
gs-4062	170	3	is	be	AUX
gs-4062	170	4	complex	complex	ADJ
gs-4062	170	5	:	:	PUNCT
gs-4062	170	6	its	its	PRON
gs-4062	170	7	outer	outer	ADJ
gs-4062	170	8	envelope	envelope	NOUN
gs-4062	170	9	,	,	PUNCT
gs-4062	170	10	studded	stud	VERB
gs-4062	170	11	with	with	ADP
gs-4062	170	12	glycoprotein	glycoprotein	NOUN
gs-4062	170	13	spikes	spike	NOUN
gs-4062	170	14	(	(	PUNCT
gs-4062	170	15	gp120	gp120	NOUN
gs-4062	170	16	and	and	CCONJ
gs-4062	170	17	gp41	gp41	PROPN
gs-4062	170	18	)	)	PUNCT
gs-4062	170	19	,	,	PUNCT
gs-4062	170	20	facilitates	facilitate	VERB
gs-4062	170	21	entry	entry	NOUN
gs-4062	170	22	into	into	ADP
gs-4062	170	23	host	host	NOUN
gs-4062	170	24	cells	cell	NOUN
gs-4062	170	25	,	,	PUNCT
gs-4062	170	26	primarily	primarily	ADV
gs-4062	170	27	cd4	cd4	PROPN
gs-4062	170	28	+	+	PROPN
gs-4062	170	29	t	t	PROPN
gs-4062	170	30	-	-	PUNCT
gs-4062	170	31	lymphocytes	lymphocyte	NOUN
gs-4062	170	32	,	,	PUNCT
gs-4062	170	33	the	the	DET
gs-4062	170	34	master	master	NOUN
gs-4062	170	35	conductors	conductor	NOUN
gs-4062	170	36	of	of	ADP
gs-4062	170	37	the	the	DET
gs-4062	170	38	adaptive	adaptive	ADJ
gs-4062	170	39	immune	immune	ADJ
gs-4062	170	40	response	response	NOUN
gs-4062	170	41	.	.	PUNCT
gs-4062	171	1	inside	inside	ADP
gs-4062	171	2	the	the	DET
gs-4062	171	3	viral	viral	ADJ
gs-4062	171	4	particle	particle	NOUN
gs-4062	171	5	,	,	PUNCT
gs-4062	171	6	two	two	NUM
gs-4062	171	7	copies	copy	NOUN
gs-4062	171	8	of	of	ADP
gs-4062	171	9	single	single	ADJ
gs-4062	171	10	-	-	PUNCT
gs-4062	171	11	stranded	strand	VERB
gs-4062	171	12	rna	rna	NOUN
gs-4062	171	13	genome	genome	NOUN
gs-4062	171	14	and	and	CCONJ
gs-4062	171	15	essential	essential	ADJ
gs-4062	171	16	enzymes	enzyme	NOUN
gs-4062	171	17	—	—	PUNCT
gs-4062	171	18	reverse	reverse	ADJ
gs-4062	171	19	transcriptase	transcriptase	NOUN
gs-4062	171	20	,	,	PUNCT
gs-4062	171	21	integrase	integrase	NOUN
gs-4062	171	22	,	,	PUNCT
gs-4062	171	23	and	and	CCONJ
gs-4062	171	24	protease	protease	NOUN
gs-4062	171	25	—	—	PUNCT
gs-4062	171	26	are	be	AUX
gs-4062	171	27	housed	house	VERB
gs-4062	171	28	within	within	ADP
gs-4062	171	29	a	a	DET
gs-4062	171	30	conical	conical	NOUN
gs-4062	171	31	capsid	capsid	NOUN
gs-4062	171	32	.	.	PUNCT
gs-4062	172	1	the	the	DET
gs-4062	172	2	replication	replication	NOUN
gs-4062	172	3	cycle	cycle	NOUN
gs-4062	172	4	is	be	AUX
gs-4062	172	5	a	a	DET
gs-4062	172	6	masterpiece	masterpiece	NOUN
gs-4062	172	7	of	of	ADP
gs-4062	172	8	biological	biological	ADJ
gs-4062	172	9	hijacking	hijacking	NOUN
gs-4062	172	10	.	.	PUNCT
gs-4062	173	1	it	it	PRON
gs-4062	173	2	begins	begin	VERB
gs-4062	173	3	with	with	ADP
gs-4062	173	4	attachment	attachment	NOUN
gs-4062	173	5	and	and	CCONJ
gs-4062	173	6	fusion	fusion	NOUN
gs-4062	173	7	,	,	PUNCT
gs-4062	173	8	where	where	SCONJ
gs-4062	173	9	gp120	gp120	NOUN
gs-4062	173	10	binds	bind	VERB
gs-4062	173	11	to	to	ADP
gs-4062	173	12	the	the	DET
gs-4062	173	13	cd4	cd4	PROPN
gs-4062	173	14	receptor	receptor	NOUN
gs-4062	173	15	and	and	CCONJ
gs-4062	173	16	a	a	DET
gs-4062	173	17	coreceptor	coreceptor	NOUN
gs-4062	173	18	(	(	PUNCT
gs-4062	173	19	ccr5	ccr5	NOUN
gs-4062	173	20	or	or	CCONJ
gs-4062	173	21	cxcr4	cxcr4	NOUN
gs-4062	173	22	)	)	PUNCT
gs-4062	173	23	on	on	ADP
gs-4062	173	24	the	the	DET
gs-4062	173	25	host	host	NOUN
gs-4062	173	26	cell	cell	NOUN
gs-4062	173	27	surface	surface	NOUN
gs-4062	173	28	,	,	PUNCT
gs-4062	173	29	allowing	allow	VERB
gs-4062	173	30	the	the	DET
gs-4062	173	31	viral	viral	ADJ
gs-4062	173	32	envelope	envelope	NOUN
gs-4062	173	33	to	to	PART
gs-4062	173	34	fuse	fuse	VERB
gs-4062	173	35	with	with	ADP
gs-4062	173	36	the	the	DET
gs-4062	173	37	cell	cell	NOUN
gs-4062	173	38	membrane	membrane	NOUN
gs-4062	173	39	.	.	PUNCT
gs-4062	174	1	the	the	DET
gs-4062	174	2	viral	viral	ADJ
gs-4062	174	3	core	core	NOUN
gs-4062	174	4	is	be	AUX
gs-4062	174	5	released	release	VERB
gs-4062	174	6	into	into	ADP
gs-4062	174	7	the	the	DET
gs-4062	174	8	georgian	georgian	NOUN
gs-4062	174	9	scientists/	scientists/	NUM
gs-4062	174	10	.	.	PUNCT
gs-4062	175	1	7	7	NUM
gs-4062	175	2	n	n	PRON
gs-4062	175	3	3	3	NUM
gs-4062	175	4	,	,	PUNCT
gs-4062	175	5	2025	2025	NUM
gs-4062	175	6	530	530	NUM
gs-4062	175	7	cytoplasm	cytoplasm	NOUN
gs-4062	175	8	,	,	PUNCT
gs-4062	175	9	where	where	SCONJ
gs-4062	175	10	reverse	reverse	ADJ
gs-4062	175	11	transcriptase	transcriptase	NOUN
gs-4062	175	12	converts	convert	VERB
gs-4062	175	13	the	the	DET
gs-4062	175	14	viral	viral	ADJ
gs-4062	175	15	rna	rna	NOUN
gs-4062	175	16	into	into	ADP
gs-4062	175	17	dna	dna	PROPN
gs-4062	175	18	.	.	PUNCT
gs-4062	176	1	this	this	DET
gs-4062	176	2	viral	viral	ADJ
gs-4062	176	3	dna	dna	NOUN
gs-4062	176	4	is	be	AUX
gs-4062	176	5	then	then	ADV
gs-4062	176	6	transported	transport	VERB
gs-4062	176	7	into	into	ADP
gs-4062	176	8	the	the	DET
gs-4062	176	9	nucleus	nucleus	NOUN
gs-4062	176	10	and	and	CCONJ
gs-4062	176	11	integrated	integrate	VERB
gs-4062	176	12	into	into	ADP
gs-4062	176	13	the	the	DET
gs-4062	176	14	host	host	NOUN
gs-4062	176	15	's	's	PART
gs-4062	176	16	chromosomal	chromosomal	ADJ
gs-4062	176	17	dna	dna	NOUN
gs-4062	176	18	by	by	ADP
gs-4062	176	19	the	the	DET
gs-4062	176	20	integrase	integrase	NOUN
gs-4062	176	21	enzyme	enzyme	NOUN
gs-4062	176	22	,	,	PUNCT
gs-4062	176	23	creating	create	VERB
gs-4062	176	24	a	a	DET
gs-4062	176	25	permanent	permanent	ADJ
gs-4062	176	26	provirus	provirus	NOUN
gs-4062	176	27	.	.	PUNCT
gs-4062	177	1	this	this	DET
gs-4062	177	2	integrated	integrate	VERB
gs-4062	177	3	provirus	provirus	NOUN
gs-4062	177	4	can	can	AUX
gs-4062	177	5	lie	lie	VERB
gs-4062	177	6	dormant	dormant	ADJ
gs-4062	177	7	for	for	ADP
gs-4062	177	8	years	year	NOUN
gs-4062	177	9	,	,	PUNCT
gs-4062	177	10	establishing	establish	VERB
gs-4062	177	11	the	the	DET
gs-4062	177	12	latent	latent	NOUN
gs-4062	177	13	reservoir	reservoir	NOUN
gs-4062	177	14	that	that	PRON
gs-4062	177	15	remains	remain	VERB
gs-4062	177	16	the	the	DET
gs-4062	177	17	fundamental	fundamental	ADJ
gs-4062	177	18	barrier	barrier	NOUN
gs-4062	177	19	to	to	ADP
gs-4062	177	20	a	a	DET
gs-4062	177	21	cure	cure	NOUN
gs-4062	177	22	.	.	PUNCT
gs-4062	178	1	upon	upon	SCONJ
gs-4062	178	2	activation	activation	NOUN
gs-4062	178	3	,	,	PUNCT
gs-4062	178	4	the	the	DET
gs-4062	178	5	host	host	NOUN
gs-4062	178	6	cell	cell	NOUN
gs-4062	178	7	's	's	PART
gs-4062	178	8	machinery	machinery	NOUN
gs-4062	178	9	is	be	AUX
gs-4062	178	10	co	co	VERB
gs-4062	178	11	-	-	VERB
gs-4062	178	12	opted	opt	VERB
gs-4062	178	13	to	to	PART
gs-4062	178	14	transcribe	transcribe	VERB
gs-4062	178	15	the	the	DET
gs-4062	178	16	viral	viral	ADJ
gs-4062	178	17	dna	dna	NOUN
gs-4062	178	18	into	into	ADP
gs-4062	178	19	new	new	ADJ
gs-4062	178	20	rna	rna	NOUN
gs-4062	178	21	strands	strand	NOUN
gs-4062	178	22	,	,	PUNCT
gs-4062	178	23	which	which	PRON
gs-4062	178	24	are	be	AUX
gs-4062	178	25	translated	translate	VERB
gs-4062	178	26	into	into	ADP
gs-4062	178	27	viral	viral	ADJ
gs-4062	178	28	proteins	protein	NOUN
gs-4062	178	29	.	.	PUNCT
gs-4062	179	1	the	the	DET
gs-4062	179	2	protease	protease	NOUN
gs-4062	179	3	enzyme	enzyme	NOUN
gs-4062	179	4	then	then	ADV
gs-4062	179	5	cleaves	cleave	VERB
gs-4062	179	6	these	these	DET
gs-4062	179	7	long	long	ADJ
gs-4062	179	8	polyproteins	polyprotein	NOUN
gs-4062	179	9	into	into	ADP
gs-4062	179	10	functional	functional	ADJ
gs-4062	179	11	units	unit	NOUN
gs-4062	179	12	.	.	PUNCT
gs-4062	180	1	finally	finally	ADV
gs-4062	180	2	,	,	PUNCT
gs-4062	180	3	new	new	ADJ
gs-4062	180	4	viral	viral	ADJ
gs-4062	180	5	particles	particle	NOUN
gs-4062	180	6	are	be	AUX
gs-4062	180	7	assembled	assemble	VERB
gs-4062	180	8	and	and	CCONJ
gs-4062	180	9	bud	bud	NOUN
gs-4062	180	10	from	from	ADP
gs-4062	180	11	the	the	DET
gs-4062	180	12	host	host	NOUN
gs-4062	180	13	cell	cell	NOUN
gs-4062	180	14	,	,	PUNCT
gs-4062	180	15	maturing	mature	VERB
gs-4062	180	16	into	into	ADP
gs-4062	180	17	infectious	infectious	ADJ
gs-4062	180	18	virions	virion	NOUN
gs-4062	180	19	ready	ready	ADJ
gs-4062	180	20	to	to	PART
gs-4062	180	21	infect	infect	VERB
gs-4062	180	22	new	new	ADJ
gs-4062	180	23	cells	cell	NOUN
gs-4062	180	24	.	.	PUNCT
gs-4062	181	1	each	each	PRON
gs-4062	181	2	of	of	ADP
gs-4062	181	3	these	these	DET
gs-4062	181	4	steps	step	NOUN
gs-4062	181	5	—	—	PUNCT
gs-4062	181	6	attachment	attachment	ADJ
gs-4062	181	7	,	,	PUNCT
gs-4062	181	8	fusion	fusion	NOUN
gs-4062	181	9	,	,	PUNCT
gs-4062	181	10	reverse	reverse	ADJ
gs-4062	181	11	transcription	transcription	NOUN
gs-4062	181	12	,	,	PUNCT
gs-4062	181	13	integration	integration	NOUN
gs-4062	181	14	,	,	PUNCT
gs-4062	181	15	and	and	CCONJ
gs-4062	181	16	proteolytic	proteolytic	ADJ
gs-4062	181	17	cleavage	cleavage	NOUN
gs-4062	181	18	—	—	PUNCT
gs-4062	181	19	would	would	AUX
gs-4062	181	20	eventually	eventually	ADV
gs-4062	181	21	become	become	VERB
gs-4062	181	22	a	a	DET
gs-4062	181	23	target	target	NOUN
gs-4062	181	24	for	for	ADP
gs-4062	181	25	therapeutic	therapeutic	ADJ
gs-4062	181	26	intervention	intervention	NOUN
gs-4062	181	27	.	.	PUNCT
gs-4062	182	1	the	the	DET
gs-4062	182	2	first	first	ADJ
gs-4062	182	3	therapeutic	therapeutic	ADJ
gs-4062	182	4	breakthrough	breakthrough	NOUN
gs-4062	182	5	came	come	VERB
gs-4062	182	6	in	in	ADP
gs-4062	182	7	1987	1987	NUM
gs-4062	182	8	with	with	ADP
gs-4062	182	9	the	the	DET
gs-4062	182	10	approval	approval	NOUN
gs-4062	182	11	of	of	ADP
gs-4062	182	12	zidovudine	zidovudine	PROPN
gs-4062	182	13	(	(	PUNCT
gs-4062	182	14	azt	azt	PROPN
gs-4062	182	15	)	)	PUNCT
gs-4062	182	16	,	,	PUNCT
gs-4062	182	17	a	a	DET
gs-4062	182	18	nucleoside	nucleoside	ADJ
gs-4062	182	19	analog	analog	NOUN
gs-4062	182	20	that	that	PRON
gs-4062	182	21	inhibits	inhibit	VERB
gs-4062	182	22	reverse	reverse	ADJ
gs-4062	182	23	transcriptase	transcriptase	NOUN
gs-4062	182	24	.	.	PUNCT
gs-4062	183	1	the	the	DET
gs-4062	183	2	initial	initial	ADJ
gs-4062	183	3	euphoria	euphoria	NOUN
gs-4062	183	4	was	be	AUX
gs-4062	183	5	short	short	ADV
gs-4062	183	6	-	-	PUNCT
gs-4062	183	7	lived	live	VERB
gs-4062	183	8	.	.	PUNCT
gs-4062	184	1	monotherapy	monotherapy	NOUN
gs-4062	184	2	with	with	ADP
gs-4062	184	3	azt	azt	PROPN
gs-4062	184	4	led	lead	VERB
gs-4062	184	5	to	to	ADP
gs-4062	184	6	only	only	ADV
gs-4062	184	7	transient	transient	VERB
gs-4062	184	8	benefits	benefit	NOUN
gs-4062	184	9	,	,	PUNCT
gs-4062	184	10	as	as	ADP
gs-4062	184	11	the	the	DET
gs-4062	184	12	high	high	ADJ
gs-4062	184	13	mutation	mutation	NOUN
gs-4062	184	14	rate	rate	NOUN
gs-4062	184	15	of	of	ADP
gs-4062	184	16	hiv	hiv	PROPN
gs-4062	184	17	—	—	PUNCT
gs-4062	184	18	a	a	DET
gs-4062	184	19	consequence	consequence	NOUN
gs-4062	184	20	of	of	ADP
gs-4062	184	21	the	the	DET
gs-4062	184	22	error	error	NOUN
gs-4062	184	23	-	-	PUNCT
gs-4062	184	24	prone	prone	ADJ
gs-4062	184	25	reverse	reverse	ADJ
gs-4062	184	26	transcriptase	transcriptase	NOUN
gs-4062	184	27	enzyme	enzyme	NOUN
gs-4062	184	28	—	—	PUNCT
gs-4062	184	29	swiftly	swiftly	ADV
gs-4062	184	30	selected	select	VERB
gs-4062	184	31	for	for	ADP
gs-4062	184	32	resistant	resistant	ADJ
gs-4062	184	33	viral	viral	ADJ
gs-4062	184	34	strains	strain	NOUN
gs-4062	184	35	.	.	PUNCT
gs-4062	185	1	the	the	DET
gs-4062	185	2	virus	virus	NOUN
gs-4062	185	3	could	could	AUX
gs-4062	185	4	evolve	evolve	VERB
gs-4062	185	5	under	under	ADP
gs-4062	185	6	drug	drug	NOUN
gs-4062	185	7	pressure	pressure	NOUN
gs-4062	185	8	with	with	ADP
gs-4062	185	9	devastating	devastating	ADJ
gs-4062	185	10	efficiency	efficiency	NOUN
gs-4062	185	11	.	.	PUNCT
gs-4062	186	1	the	the	DET
gs-4062	186	2	late	late	ADJ
gs-4062	186	3	1980s	1980	NOUN
gs-4062	186	4	and	and	CCONJ
gs-4062	186	5	early	early	ADJ
gs-4062	186	6	1990s	1990	NOUN
gs-4062	186	7	were	be	AUX
gs-4062	186	8	a	a	DET
gs-4062	186	9	period	period	NOUN
gs-4062	186	10	of	of	ADP
gs-4062	186	11	therapeutic	therapeutic	ADJ
gs-4062	186	12	despair	despair	NOUN
gs-4062	186	13	,	,	PUNCT
gs-4062	186	14	marked	mark	VERB
gs-4062	186	15	by	by	ADP
gs-4062	186	16	the	the	DET
gs-4062	186	17	successive	successive	ADJ
gs-4062	186	18	introduction	introduction	NOUN
gs-4062	186	19	of	of	ADP
gs-4062	186	20	other	other	ADJ
gs-4062	186	21	nucleoside	nucleoside	ADV
gs-4062	186	22	reverse	reverse	ADJ
gs-4062	186	23	transcriptase	transcriptase	NOUN
gs-4062	186	24	inhibitors	inhibitor	NOUN
gs-4062	186	25	(	(	PUNCT
gs-4062	186	26	nrtis	nrtis	PROPN
gs-4062	186	27	)	)	PUNCT
gs-4062	186	28	like	like	ADP
gs-4062	186	29	didanosine	didanosine	NOUN
gs-4062	186	30	and	and	CCONJ
gs-4062	186	31	zalcitabine	zalcitabine	PROPN
gs-4062	186	32	,	,	PUNCT
gs-4062	186	33	used	use	VERB
gs-4062	186	34	sequentially	sequentially	ADV
gs-4062	186	35	or	or	CCONJ
gs-4062	186	36	in	in	ADP
gs-4062	186	37	combination	combination	NOUN
gs-4062	186	38	with	with	ADP
gs-4062	186	39	azt	azt	PROPN
gs-4062	186	40	,	,	PUNCT
gs-4062	186	41	but	but	CCONJ
gs-4062	186	42	with	with	ADP
gs-4062	186	43	marginal	marginal	ADJ
gs-4062	186	44	improvements	improvement	NOUN
gs-4062	186	45	in	in	ADP
gs-4062	186	46	outcomes	outcome	NOUN
gs-4062	186	47	.	.	PUNCT
gs-4062	187	1	mortality	mortality	NOUN
gs-4062	187	2	rates	rate	NOUN
gs-4062	187	3	remained	remain	VERB
gs-4062	187	4	staggeringly	staggeringly	ADV
gs-4062	187	5	high	high	ADJ
gs-4062	187	6	,	,	PUNCT
gs-4062	187	7	and	and	CCONJ
gs-4062	187	8	clinics	clinic	NOUN
gs-4062	187	9	were	be	AUX
gs-4062	187	10	filled	fill	VERB
gs-4062	187	11	with	with	ADP
gs-4062	187	12	patients	patient	NOUN
gs-4062	187	13	dying	die	VERB
gs-4062	187	14	from	from	ADP
gs-4062	187	15	horrific	horrific	ADJ
gs-4062	187	16	opportunistic	opportunistic	ADJ
gs-4062	187	17	infections	infection	NOUN
gs-4062	187	18	.	.	PUNCT
gs-4062	188	1	this	this	DET
gs-4062	188	2	period	period	NOUN
gs-4062	188	3	underscored	underscore	VERB
gs-4062	188	4	a	a	DET
gs-4062	188	5	fundamental	fundamental	ADJ
gs-4062	188	6	virological	virological	ADJ
gs-4062	188	7	truth	truth	NOUN
gs-4062	188	8	that	that	PRON
gs-4062	188	9	would	would	AUX
gs-4062	188	10	define	define	VERB
gs-4062	188	11	all	all	DET
gs-4062	188	12	future	future	ADJ
gs-4062	188	13	hiv	hiv	PROPN
gs-4062	188	14	treatment	treatment	NOUN
gs-4062	188	15	:	:	PUNCT
gs-4062	188	16	to	to	PART
gs-4062	188	17	corner	corner	VERB
gs-4062	188	18	a	a	DET
gs-4062	188	19	virus	virus	NOUN
gs-4062	188	20	with	with	ADP
gs-4062	188	21	such	such	ADJ
gs-4062	188	22	immense	immense	ADJ
gs-4062	188	23	replicative	replicative	ADJ
gs-4062	188	24	and	and	CCONJ
gs-4062	188	25	mutational	mutational	ADJ
gs-4062	188	26	capacity	capacity	NOUN
gs-4062	188	27	,	,	PUNCT
gs-4062	188	28	it	it	PRON
gs-4062	188	29	must	must	AUX
gs-4062	188	30	be	be	AUX
gs-4062	188	31	hit	hit	VERB
gs-4062	188	32	hard	hard	ADV
gs-4062	188	33	and	and	CCONJ
gs-4062	188	34	hit	hit	VERB
gs-4062	188	35	simultaneously	simultaneously	ADV
gs-4062	188	36	with	with	ADP
gs-4062	188	37	multiple	multiple	ADJ
gs-4062	188	38	drugs	drug	NOUN
gs-4062	188	39	.	.	PUNCT
gs-4062	189	1	the	the	DET
gs-4062	189	2	true	true	ADJ
gs-4062	189	3	turning	turning	NOUN
gs-4062	189	4	point	point	NOUN
gs-4062	189	5	,	,	PUNCT
gs-4062	189	6	often	often	ADV
gs-4062	189	7	called	call	VERB
gs-4062	189	8	the	the	DET
gs-4062	189	9	"	"	PUNCT
gs-4062	189	10	lazarus	lazarus	PROPN
gs-4062	189	11	era	era	PROPN
gs-4062	189	12	,	,	PUNCT
gs-4062	189	13	"	"	PUNCT
gs-4062	189	14	arrived	arrive	VERB
gs-4062	189	15	in	in	ADP
gs-4062	189	16	1996	1996	NUM
gs-4062	189	17	with	with	ADP
gs-4062	189	18	the	the	DET
gs-4062	189	19	advent	advent	NOUN
gs-4062	189	20	of	of	ADP
gs-4062	189	21	protease	protease	NOUN
gs-4062	189	22	inhibitors	inhibitor	NOUN
gs-4062	189	23	(	(	PUNCT
gs-4062	189	24	pis	pis	NOUN
gs-4062	189	25	)	)	PUNCT
gs-4062	189	26	and	and	CCONJ
gs-4062	189	27	the	the	DET
gs-4062	189	28	formalization	formalization	NOUN
gs-4062	189	29	of	of	ADP
gs-4062	189	30	combination	combination	NOUN
gs-4062	189	31	therapy	therapy	NOUN
gs-4062	189	32	.	.	PUNCT
gs-4062	190	1	the	the	DET
gs-4062	190	2	introduction	introduction	NOUN
gs-4062	190	3	of	of	ADP
gs-4062	190	4	saquinavir	saquinavir	PROPN
gs-4062	190	5	,	,	PUNCT
gs-4062	190	6	ritonavir	ritonavir	PROPN
gs-4062	190	7	,	,	PUNCT
gs-4062	190	8	and	and	CCONJ
gs-4062	190	9	indinavir	indinavir	NOUN
gs-4062	190	10	represented	represent	VERB
gs-4062	190	11	a	a	DET
gs-4062	190	12	completely	completely	ADV
gs-4062	190	13	new	new	ADJ
gs-4062	190	14	class	class	NOUN
gs-4062	190	15	of	of	ADP
gs-4062	190	16	drugs	drug	NOUN
gs-4062	190	17	that	that	PRON
gs-4062	190	18	targeted	target	VERB
gs-4062	190	19	a	a	DET
gs-4062	190	20	different	different	ADJ
gs-4062	190	21	,	,	PUNCT
gs-4062	190	22	essential	essential	ADJ
gs-4062	190	23	viral	viral	ADJ
gs-4062	190	24	enzyme	enzyme	NOUN
gs-4062	190	25	.	.	PUNCT
gs-4062	191	1	when	when	SCONJ
gs-4062	191	2	combined	combine	VERB
gs-4062	191	3	with	with	ADP
gs-4062	191	4	two	two	NUM
gs-4062	191	5	nrtis	nrti	NOUN
gs-4062	191	6	,	,	PUNCT
gs-4062	191	7	these	these	DET
gs-4062	191	8	regimens	regimen	NOUN
gs-4062	191	9	—	—	PUNCT
gs-4062	191	10	dubbed	dub	VERB
gs-4062	191	11	highly	highly	ADV
gs-4062	191	12	active	active	ADJ
gs-4062	191	13	antiretroviral	antiretroviral	ADJ
gs-4062	191	14	therapy	therapy	NOUN
gs-4062	191	15	(	(	PUNCT
gs-4062	191	16	haart)—produced	haart)—produce	VERB
gs-4062	191	17	dramatic	dramatic	ADJ
gs-4062	191	18	and	and	CCONJ
gs-4062	191	19	sustained	sustained	ADJ
gs-4062	191	20	suppression	suppression	NOUN
gs-4062	191	21	of	of	ADP
gs-4062	191	22	viral	viral	ADJ
gs-4062	191	23	replication	replication	NOUN
gs-4062	191	24	.	.	PUNCT
gs-4062	192	1	patients	patient	NOUN
gs-4062	192	2	on	on	ADP
gs-4062	192	3	the	the	DET
gs-4062	192	4	brink	brink	NOUN
gs-4062	192	5	of	of	ADP
gs-4062	192	6	death	death	NOUN
gs-4062	192	7	experienced	experience	VERB
gs-4062	192	8	miraculous	miraculous	ADJ
gs-4062	192	9	recoveries	recovery	NOUN
gs-4062	192	10	,	,	PUNCT
gs-4062	192	11	rising	rise	VERB
gs-4062	192	12	from	from	ADP
gs-4062	192	13	their	their	PRON
gs-4062	192	14	sickbeds	sickbed	NOUN
gs-4062	192	15	.	.	PUNCT
gs-4062	193	1	hospitals	hospital	NOUN
gs-4062	193	2	wards	ward	NOUN
gs-4062	193	3	dedicated	dedicate	VERB
gs-4062	193	4	to	to	ADP
gs-4062	193	5	aids	aid	NOUN
gs-4062	193	6	-	-	PUNCT
gs-4062	193	7	related	relate	VERB
gs-4062	193	8	illnesses	illness	NOUN
gs-4062	193	9	began	begin	VERB
gs-4062	193	10	to	to	PART
gs-4062	193	11	empty	empty	VERB
gs-4062	193	12	.	.	PUNCT
gs-4062	194	1	the	the	DET
gs-4062	194	2	effect	effect	NOUN
gs-4062	194	3	on	on	ADP
gs-4062	194	4	mortality	mortality	NOUN
gs-4062	194	5	and	and	CCONJ
gs-4062	194	6	morbidity	morbidity	NOUN
gs-4062	194	7	in	in	ADP
gs-4062	194	8	countries	country	NOUN
gs-4062	194	9	with	with	ADP
gs-4062	194	10	access	access	NOUN
gs-4062	194	11	to	to	ADP
gs-4062	194	12	these	these	DET
gs-4062	194	13	drugs	drug	NOUN
gs-4062	194	14	was	be	AUX
gs-4062	194	15	nothing	nothing	PRON
gs-4062	194	16	short	short	ADJ
gs-4062	194	17	of	of	ADP
gs-4062	194	18	revolutionary	revolutionary	ADJ
gs-4062	194	19	.	.	PUNCT
gs-4062	195	1	haart	haart	PROPN
gs-4062	195	2	established	establish	VERB
gs-4062	195	3	the	the	DET
gs-4062	195	4	foundational	foundational	ADJ
gs-4062	195	5	principle	principle	NOUN
gs-4062	195	6	of	of	ADP
gs-4062	195	7	modern	modern	ADJ
gs-4062	195	8	hiv	hiv	PROPN
gs-4062	195	9	therapy	therapy	NOUN
gs-4062	195	10	:	:	PUNCT
gs-4062	195	11	combination	combination	NOUN
gs-4062	195	12	art	art	NOUN
gs-4062	195	13	(	(	PUNCT
gs-4062	195	14	cart	cart	NOUN
gs-4062	195	15	)	)	PUNCT
gs-4062	195	16	aimed	aim	VERB
gs-4062	195	17	at	at	ADP
gs-4062	195	18	achieving	achieve	VERB
gs-4062	195	19	and	and	CCONJ
gs-4062	195	20	maintaining	maintain	VERB
gs-4062	195	21	an	an	DET
gs-4062	195	22	undetectable	undetectable	ADJ
gs-4062	195	23	plasma	plasma	NOUN
gs-4062	195	24	viral	viral	ADJ
gs-4062	195	25	load	load	NOUN
gs-4062	195	26	,	,	PUNCT
gs-4062	195	27	typically	typically	ADV
gs-4062	195	28	defined	define	VERB
gs-4062	195	29	as	as	ADP
gs-4062	195	30	less	less	ADJ
gs-4062	195	31	than	than	ADP
gs-4062	195	32	50	50	NUM
gs-4062	195	33	copies	copy	NOUN
gs-4062	195	34	/	/	SYM
gs-4062	195	35	ml	ml	NOUN
gs-4062	195	36	.	.	PUNCT
gs-4062	196	1	however	however	ADV
gs-4062	196	2	,	,	PUNCT
gs-4062	196	3	this	this	DET
gs-4062	196	4	first	first	ADJ
gs-4062	196	5	generation	generation	NOUN
gs-4062	196	6	of	of	ADP
gs-4062	196	7	haart	haart	PROPN
gs-4062	196	8	came	come	VERB
gs-4062	196	9	with	with	ADP
gs-4062	196	10	a	a	DET
gs-4062	196	11	heavy	heavy	ADJ
gs-4062	196	12	price	price	NOUN
gs-4062	196	13	.	.	PUNCT
gs-4062	197	1	the	the	DET
gs-4062	197	2	regimens	regimen	NOUN
gs-4062	197	3	were	be	AUX
gs-4062	197	4	notoriously	notoriously	ADV
gs-4062	197	5	complex	complex	ADJ
gs-4062	197	6	and	and	CCONJ
gs-4062	197	7	burdensome	burdensome	ADJ
gs-4062	197	8	.	.	PUNCT
gs-4062	198	1	patients	patient	NOUN
gs-4062	198	2	had	have	VERB
gs-4062	198	3	to	to	PART
gs-4062	198	4	take	take	VERB
gs-4062	198	5	dozens	dozen	NOUN
gs-4062	198	6	of	of	ADP
gs-4062	198	7	pills	pill	NOUN
gs-4062	198	8	a	a	DET
gs-4062	198	9	day	day	NOUN
gs-4062	198	10	on	on	ADP
gs-4062	198	11	strict	strict	ADJ
gs-4062	198	12	,	,	PUNCT
gs-4062	198	13	often	often	ADV
gs-4062	198	14	inconvenient	inconvenient	ADJ
gs-4062	198	15	schedules	schedule	NOUN
gs-4062	198	16	,	,	PUNCT
gs-4062	198	17	some	some	PRON
gs-4062	198	18	with	with	ADP
gs-4062	198	19	large	large	ADJ
gs-4062	198	20	high	high	ADJ
gs-4062	198	21	-	-	PUNCT
gs-4062	198	22	fat	fat	NOUN
gs-4062	198	23	meals	meal	NOUN
gs-4062	198	24	and	and	CCONJ
gs-4062	198	25	others	other	NOUN
gs-4062	198	26	on	on	ADP
gs-4062	198	27	an	an	DET
gs-4062	198	28	empty	empty	ADJ
gs-4062	198	29	stomach	stomach	NOUN
gs-4062	198	30	.	.	PUNCT
gs-4062	199	1	the	the	DET
gs-4062	199	2	side	side	NOUN
gs-4062	199	3	effects	effect	NOUN
gs-4062	199	4	were	be	AUX
gs-4062	199	5	severe	severe	ADJ
gs-4062	199	6	and	and	CCONJ
gs-4062	199	7	could	could	AUX
gs-4062	199	8	be	be	AUX
gs-4062	199	9	disfiguring	disfigure	VERB
gs-4062	199	10	and	and	CCONJ
gs-4062	199	11	debilitating	debilitate	VERB
gs-4062	199	12	.	.	PUNCT
gs-4062	200	1	protease	protease	NOUN
gs-4062	200	2	inhibitors	inhibitor	NOUN
gs-4062	200	3	were	be	AUX
gs-4062	200	4	associated	associate	VERB
gs-4062	200	5	with	with	ADP
gs-4062	200	6	lipodystrophy	lipodystrophy	NOUN
gs-4062	200	7	—	—	PUNCT
gs-4062	200	8	a	a	DET
gs-4062	200	9	pervasive	pervasive	ADJ
gs-4062	200	10	redistribution	redistribution	NOUN
gs-4062	200	11	of	of	ADP
gs-4062	200	12	body	body	NOUN
gs-4062	200	13	fat	fat	NOUN
gs-4062	200	14	characterized	characterize	VERB
gs-4062	200	15	by	by	ADP
gs-4062	200	16	peripheral	peripheral	ADJ
gs-4062	200	17	fat	fat	ADJ
gs-4062	200	18	wasting	wasting	NOUN
gs-4062	200	19	(	(	PUNCT
gs-4062	200	20	in	in	ADP
gs-4062	200	21	the	the	DET
gs-4062	200	22	face	face	NOUN
gs-4062	200	23	,	,	PUNCT
gs-4062	200	24	arms	arm	NOUN
gs-4062	200	25	,	,	PUNCT
gs-4062	200	26	and	and	CCONJ
gs-4062	200	27	legs	leg	NOUN
gs-4062	200	28	)	)	PUNCT
gs-4062	200	29	and	and	CCONJ
gs-4062	200	30	central	central	ADJ
gs-4062	200	31	fat	fat	ADJ
gs-4062	200	32	accumulation	accumulation	NOUN
gs-4062	200	33	(	(	PUNCT
gs-4062	200	34	in	in	ADP
gs-4062	200	35	the	the	DET
gs-4062	200	36	abdomen	abdomen	NOUN
gs-4062	200	37	and	and	CCONJ
gs-4062	200	38	as	as	ADP
gs-4062	200	39	a	a	DET
gs-4062	200	40	"	"	PUNCT
gs-4062	200	41	buffalo	buffalo	NOUN
gs-4062	200	42	hump	hump	NOUN
gs-4062	200	43	"	"	PUNCT
gs-4062	200	44	on	on	ADP
gs-4062	200	45	the	the	DET
gs-4062	200	46	back)—as	back)—as	NOUN
gs-4062	200	47	well	well	ADV
gs-4062	200	48	as	as	ADP
gs-4062	200	49	severe	severe	ADJ
gs-4062	200	50	dyslipidemia	dyslipidemia	NOUN
gs-4062	200	51	and	and	CCONJ
gs-4062	200	52	insulin	insulin	NOUN
gs-4062	200	53	resistance	resistance	NOUN
gs-4062	200	54	.	.	PUNCT
gs-4062	201	1	nrtis	nrtis	PROPN
gs-4062	201	2	like	like	ADP
gs-4062	201	3	stavudine	stavudine	PROPN
gs-4062	201	4	and	and	CCONJ
gs-4062	201	5	zidovudine	zidovudine	PROPN
gs-4062	201	6	caused	cause	VERB
gs-4062	201	7	mitochondrial	mitochondrial	ADJ
gs-4062	201	8	toxicity	toxicity	NOUN
gs-4062	201	9	,	,	PUNCT
gs-4062	201	10	leading	lead	VERB
gs-4062	201	11	to	to	ADP
gs-4062	201	12	peripheral	peripheral	ADJ
gs-4062	201	13	neuropathy	neuropathy	ADJ
gs-4062	201	14	,	,	PUNCT
gs-4062	201	15	pancreatitis	pancreatitis	NOUN
gs-4062	201	16	,	,	PUNCT
gs-4062	201	17	and	and	CCONJ
gs-4062	201	18	lactic	lactic	ADJ
gs-4062	201	19	acidosis	acidosis	NOUN
gs-4062	201	20	.	.	PUNCT
gs-4062	202	1	the	the	DET
gs-4062	202	2	psychological	psychological	ADJ
gs-4062	202	3	toll	toll	NOUN
gs-4062	202	4	of	of	ADP
gs-4062	202	5	these	these	DET
gs-4062	202	6	toxicities	toxicity	NOUN
gs-4062	202	7	was	be	AUX
gs-4062	202	8	immense	immense	ADJ
gs-4062	202	9	,	,	PUNCT
gs-4062	202	10	as	as	ADP
gs-4062	202	11	the	the	DET
gs-4062	202	12	very	very	ADJ
gs-4062	202	13	treatments	treatment	NOUN
gs-4062	202	14	that	that	PRON
gs-4062	202	15	saved	save	VERB
gs-4062	202	16	georgian	georgian	NOUN
gs-4062	202	17	scientists/	scientists/	NUM
gs-4062	202	18	.	.	PUNCT
gs-4062	203	1	7	7	NUM
gs-4062	203	2	n	n	PRON
gs-4062	203	3	3	3	NUM
gs-4062	203	4	,	,	PUNCT
gs-4062	203	5	2025	2025	NUM
gs-4062	203	6	531	531	NUM
gs-4062	203	7	lives	life	NOUN
gs-4062	203	8	also	also	ADV
gs-4062	203	9	made	make	VERB
gs-4062	203	10	them	they	PRON
gs-4062	203	11	physically	physically	ADV
gs-4062	203	12	and	and	CCONJ
gs-4062	203	13	socially	socially	ADV
gs-4062	203	14	difficult	difficult	ADJ
gs-4062	203	15	,	,	PUNCT
gs-4062	203	16	serving	serve	VERB
gs-4062	203	17	as	as	ADP
gs-4062	203	18	constant	constant	ADJ
gs-4062	203	19	,	,	PUNCT
gs-4062	203	20	visible	visible	ADJ
gs-4062	203	21	stigmas	stigma	NOUN
gs-4062	203	22	of	of	ADP
gs-4062	203	23	their	their	PRON
gs-4062	203	24	disease	disease	NOUN
gs-4062	203	25	.	.	PUNCT
gs-4062	204	1	the	the	DET
gs-4062	204	2	next	next	ADJ
gs-4062	204	3	decade	decade	NOUN
gs-4062	204	4	,	,	PUNCT
gs-4062	204	5	from	from	ADP
gs-4062	204	6	approximately	approximately	ADV
gs-4062	204	7	2000	2000	NUM
gs-4062	204	8	to	to	ADP
gs-4062	204	9	2010	2010	NUM
gs-4062	204	10	,	,	PUNCT
gs-4062	204	11	was	be	AUX
gs-4062	204	12	an	an	DET
gs-4062	204	13	era	era	NOUN
gs-4062	204	14	of	of	ADP
gs-4062	204	15	refinement	refinement	NOUN
gs-4062	204	16	and	and	CCONJ
gs-4062	204	17	simplification	simplification	NOUN
gs-4062	204	18	,	,	PUNCT
gs-4062	204	19	driven	drive	VERB
gs-4062	204	20	by	by	ADP
gs-4062	204	21	the	the	DET
gs-4062	204	22	goal	goal	NOUN
gs-4062	204	23	of	of	ADP
gs-4062	204	24	improving	improve	VERB
gs-4062	204	25	quality	quality	NOUN
gs-4062	204	26	of	of	ADP
gs-4062	204	27	life	life	NOUN
gs-4062	204	28	and	and	CCONJ
gs-4062	204	29	long	long	ADJ
gs-4062	204	30	-	-	PUNCT
gs-4062	204	31	term	term	NOUN
gs-4062	204	32	safety	safety	NOUN
gs-4062	204	33	.	.	PUNCT
gs-4062	205	1	the	the	DET
gs-4062	205	2	treatment	treatment	NOUN
gs-4062	205	3	arsenal	arsenal	NOUN
gs-4062	205	4	expanded	expand	VERB
gs-4062	205	5	with	with	ADP
gs-4062	205	6	new	new	ADJ
gs-4062	205	7	drug	drug	NOUN
gs-4062	205	8	classes	class	NOUN
gs-4062	205	9	,	,	PUNCT
gs-4062	205	10	providing	provide	VERB
gs-4062	205	11	more	more	ADJ
gs-4062	205	12	options	option	NOUN
gs-4062	205	13	and	and	CCONJ
gs-4062	205	14	strategies	strategy	NOUN
gs-4062	205	15	.	.	PUNCT
gs-4062	206	1	the	the	DET
gs-4062	206	2	non	non	ADJ
gs-4062	206	3	-	-	ADJ
gs-4062	206	4	nucleoside	nucleoside	ADJ
gs-4062	206	5	reverse	reverse	ADJ
gs-4062	206	6	transcriptase	transcriptase	NOUN
gs-4062	206	7	inhibitors	inhibitor	NOUN
gs-4062	206	8	(	(	PUNCT
gs-4062	206	9	nnrtis	nnrtis	ADJ
gs-4062	206	10	)	)	PUNCT
gs-4062	206	11	,	,	PUNCT
gs-4062	206	12	such	such	ADJ
gs-4062	206	13	as	as	ADP
gs-4062	206	14	efavirenz	efavirenz	NOUN
gs-4062	206	15	and	and	CCONJ
gs-4062	206	16	nevirapine	nevirapine	ADJ
gs-4062	206	17	,	,	PUNCT
gs-4062	206	18	offered	offer	VERB
gs-4062	206	19	a	a	DET
gs-4062	206	20	potent	potent	ADJ
gs-4062	206	21	oncedaily	oncedaily	ADJ
gs-4062	206	22	pill	pill	NOUN
gs-4062	206	23	but	but	CCONJ
gs-4062	206	24	brought	bring	VERB
gs-4062	206	25	their	their	PRON
gs-4062	206	26	own	own	ADJ
gs-4062	206	27	challenges	challenge	NOUN
gs-4062	206	28	,	,	PUNCT
gs-4062	206	29	including	include	VERB
gs-4062	206	30	neuropsychiatric	neuropsychiatric	ADJ
gs-4062	206	31	side	side	NOUN
gs-4062	206	32	effects	effect	NOUN
gs-4062	206	33	and	and	CCONJ
gs-4062	206	34	rash	rash	NOUN
gs-4062	206	35	.	.	PUNCT
gs-4062	207	1	the	the	DET
gs-4062	207	2	entry	entry	NOUN
gs-4062	207	3	inhibitor	inhibitor	NOUN
gs-4062	207	4	enfuvirtide	enfuvirtide	NOUN
gs-4062	207	5	,	,	PUNCT
gs-4062	207	6	requiring	require	VERB
gs-4062	207	7	twice	twice	ADV
gs-4062	207	8	-	-	PUNCT
gs-4062	207	9	daily	daily	ADJ
gs-4062	207	10	subcutaneous	subcutaneous	ADJ
gs-4062	207	11	injections	injection	NOUN
gs-4062	207	12	,	,	PUNCT
gs-4062	207	13	was	be	AUX
gs-4062	207	14	a	a	DET
gs-4062	207	15	difficult	difficult	ADJ
gs-4062	207	16	-	-	PUNCT
gs-4062	207	17	to	to	ADP
gs-4062	207	18	-	-	PUNCT
gs-4062	207	19	use	use	NOUN
gs-4062	207	20	but	but	CCONJ
gs-4062	207	21	life	life	NOUN
gs-4062	207	22	-	-	PUNCT
gs-4062	207	23	saving	save	VERB
gs-4062	207	24	option	option	NOUN
gs-4062	207	25	for	for	ADP
gs-4062	207	26	highly	highly	ADV
gs-4062	207	27	treatment	treatment	NOUN
gs-4062	207	28	-	-	PUNCT
gs-4062	207	29	experienced	experience	VERB
gs-4062	207	30	patients	patient	NOUN
gs-4062	207	31	.	.	PUNCT
gs-4062	208	1	perhaps	perhaps	ADV
gs-4062	208	2	the	the	DET
gs-4062	208	3	most	most	ADV
gs-4062	208	4	significant	significant	ADJ
gs-4062	208	5	class	class	NOUN
gs-4062	208	6	introduced	introduce	VERB
gs-4062	208	7	during	during	ADP
gs-4062	208	8	this	this	DET
gs-4062	208	9	period	period	NOUN
gs-4062	208	10	was	be	AUX
gs-4062	208	11	the	the	DET
gs-4062	208	12	integrase	integrase	NOUN
gs-4062	208	13	strand	strand	NOUN
gs-4062	208	14	transfer	transfer	NOUN
gs-4062	208	15	inhibitors	inhibitor	NOUN
gs-4062	208	16	(	(	PUNCT
gs-4062	208	17	instis	instis	NOUN
gs-4062	208	18	)	)	PUNCT
gs-4062	208	19	.	.	PUNCT
gs-4062	209	1	raltegravir	raltegravir	PROPN
gs-4062	209	2	,	,	PUNCT
gs-4062	209	3	the	the	DET
gs-4062	209	4	first	first	ADJ
gs-4062	209	5	in	in	ADP
gs-4062	209	6	its	its	PRON
gs-4062	209	7	class	class	NOUN
gs-4062	209	8	approved	approve	VERB
gs-4062	209	9	in	in	ADP
gs-4062	209	10	2007	2007	NUM
gs-4062	209	11	,	,	PUNCT
gs-4062	209	12	offered	offer	VERB
gs-4062	209	13	potent	potent	NOUN
gs-4062	209	14	,	,	PUNCT
gs-4062	209	15	rapid	rapid	ADJ
gs-4062	209	16	viral	viral	ADJ
gs-4062	209	17	suppression	suppression	NOUN
gs-4062	209	18	with	with	ADP
gs-4062	209	19	a	a	DET
gs-4062	209	20	clean	clean	ADJ
gs-4062	209	21	side	side	NOUN
gs-4062	209	22	effect	effect	NOUN
gs-4062	209	23	profile	profile	NOUN
gs-4062	209	24	,	,	PUNCT
gs-4062	209	25	heralding	herald	VERB
gs-4062	209	26	a	a	DET
gs-4062	209	27	new	new	ADJ
gs-4062	209	28	future	future	NOUN
gs-4062	209	29	for	for	ADP
gs-4062	209	30	hiv	hiv	PROPN
gs-4062	209	31	therapy	therapy	NOUN
gs-4062	209	32	.	.	PUNCT
gs-4062	210	1	a	a	DET
gs-4062	210	2	critical	critical	ADJ
gs-4062	210	3	pharmacological	pharmacological	NOUN
gs-4062	210	4	advancement	advancement	NOUN
gs-4062	210	5	was	be	AUX
gs-4062	210	6	the	the	DET
gs-4062	210	7	strategic	strategic	ADJ
gs-4062	210	8	use	use	NOUN
gs-4062	210	9	of	of	ADP
gs-4062	210	10	pharmacokinetic	pharmacokinetic	ADJ
gs-4062	210	11	enhancers	enhancer	NOUN
gs-4062	210	12	,	,	PUNCT
gs-4062	210	13	or	or	CCONJ
gs-4062	210	14	boosters	booster	NOUN
gs-4062	210	15	.	.	PUNCT
gs-4062	211	1	the	the	DET
gs-4062	211	2	pi	pi	NOUN
gs-4062	211	3	ritonavir	ritonavir	PROPN
gs-4062	211	4	,	,	PUNCT
gs-4062	211	5	at	at	ADP
gs-4062	211	6	a	a	DET
gs-4062	211	7	low	low	ADJ
gs-4062	211	8	dose	dose	NOUN
gs-4062	211	9	,	,	PUNCT
gs-4062	211	10	was	be	AUX
gs-4062	211	11	found	find	VERB
gs-4062	211	12	to	to	PART
gs-4062	211	13	potently	potently	ADV
gs-4062	211	14	inhibit	inhibit	VERB
gs-4062	211	15	the	the	DET
gs-4062	211	16	cytochrome	cytochrome	NOUN
gs-4062	211	17	p450	p450	PROPN
gs-4062	212	1	3a4	3a4	NUM
gs-4062	212	2	enzyme	enzyme	NOUN
gs-4062	212	3	in	in	ADP
gs-4062	212	4	the	the	DET
gs-4062	212	5	liver	liver	NOUN
gs-4062	212	6	,	,	PUNCT
gs-4062	212	7	thereby	thereby	ADV
gs-4062	212	8	dramatically	dramatically	ADV
gs-4062	212	9	increasing	increase	VERB
gs-4062	212	10	(	(	PUNCT
gs-4062	212	11	"	"	PUNCT
gs-4062	212	12	boosting	boost	VERB
gs-4062	212	13	"	"	PUNCT
gs-4062	212	14	)	)	PUNCT
gs-4062	212	15	the	the	DET
gs-4062	212	16	exposure	exposure	NOUN
gs-4062	212	17	levels	level	NOUN
gs-4062	212	18	of	of	ADP
gs-4062	212	19	other	other	ADJ
gs-4062	212	20	co	co	ADJ
gs-4062	212	21	-	-	ADJ
gs-4062	212	22	administered	administered	ADJ
gs-4062	212	23	pis	pis	NOUN
gs-4062	212	24	.	.	PUNCT
gs-4062	213	1	this	this	PRON
gs-4062	213	2	allowed	allow	VERB
gs-4062	213	3	for	for	ADP
gs-4062	213	4	improved	improved	ADJ
gs-4062	213	5	efficacy	efficacy	NOUN
gs-4062	213	6	,	,	PUNCT
gs-4062	213	7	reduced	reduce	VERB
gs-4062	213	8	pill	pill	NOUN
gs-4062	213	9	burden	burden	NOUN
gs-4062	213	10	,	,	PUNCT
gs-4062	213	11	and	and	CCONJ
gs-4062	213	12	less	less	ADV
gs-4062	213	13	frequent	frequent	ADJ
gs-4062	213	14	dosing	dosing	NOUN
gs-4062	213	15	.	.	PUNCT
gs-4062	214	1	this	this	DET
gs-4062	214	2	principle	principle	NOUN
gs-4062	214	3	was	be	AUX
gs-4062	214	4	later	later	ADV
gs-4062	214	5	extended	extend	VERB
gs-4062	214	6	to	to	ADP
gs-4062	214	7	cobicistat	cobicistat	NOUN
gs-4062	214	8	,	,	PUNCT
gs-4062	214	9	a	a	DET
gs-4062	214	10	dedicated	dedicated	ADJ
gs-4062	214	11	booster	booster	NOUN
gs-4062	214	12	without	without	ADP
gs-4062	214	13	antiviral	antiviral	ADJ
gs-4062	214	14	activity	activity	NOUN
gs-4062	214	15	.	.	PUNCT
gs-4062	215	1	the	the	DET
gs-4062	215	2	development	development	NOUN
gs-4062	215	3	of	of	ADP
gs-4062	215	4	fixed	fix	VERB
gs-4062	215	5	-	-	PUNCT
gs-4062	215	6	dose	dose	NOUN
gs-4062	215	7	combinations	combination	NOUN
gs-4062	215	8	(	(	PUNCT
gs-4062	215	9	fdcs	fdc	NOUN
gs-4062	215	10	)	)	PUNCT
gs-4062	215	11	was	be	AUX
gs-4062	215	12	another	another	DET
gs-4062	215	13	leap	leap	NOUN
gs-4062	215	14	forward	forward	ADV
gs-4062	215	15	,	,	PUNCT
gs-4062	215	16	consolidating	consolidate	VERB
gs-4062	215	17	multiple	multiple	ADJ
gs-4062	215	18	drugs	drug	NOUN
gs-4062	215	19	into	into	ADP
gs-4062	215	20	a	a	DET
gs-4062	215	21	single	single	ADJ
gs-4062	215	22	tablet	tablet	NOUN
gs-4062	215	23	.	.	PUNCT
gs-4062	216	1	this	this	PRON
gs-4062	216	2	began	begin	VERB
gs-4062	216	3	with	with	ADP
gs-4062	216	4	two	two	NUM
gs-4062	216	5	-	-	PUNCT
gs-4062	216	6	drug	drug	NOUN
gs-4062	216	7	combinations	combination	NOUN
gs-4062	216	8	and	and	CCONJ
gs-4062	216	9	eventually	eventually	ADV
gs-4062	216	10	culminated	culminate	VERB
gs-4062	216	11	in	in	ADP
gs-4062	216	12	the	the	DET
gs-4062	216	13	first	first	ADJ
gs-4062	216	14	single	single	ADJ
gs-4062	216	15	-	-	PUNCT
gs-4062	216	16	tablet	tablet	NOUN
gs-4062	216	17	regimen	regiman	NOUN
gs-4062	216	18	(	(	PUNCT
gs-4062	216	19	str	str	NOUN
gs-4062	216	20	)	)	PUNCT
gs-4062	216	21	,	,	PUNCT
gs-4062	216	22	atripla	atripla	NOUN
gs-4062	216	23	(	(	PUNCT
gs-4062	216	24	efavirenz	efavirenz	PROPN
gs-4062	216	25	/	/	SYM
gs-4062	216	26	emtricitabine	emtricitabine	NOUN
gs-4062	216	27	/	/	SYM
gs-4062	216	28	tenofovir	tenofovir	PROPN
gs-4062	216	29	disoproxil	disoproxil	VERB
gs-4062	216	30	fumarate	fumarate	NOUN
gs-4062	216	31	)	)	PUNCT
gs-4062	216	32	,	,	PUNCT
gs-4062	216	33	in	in	ADP
gs-4062	216	34	2006	2006	NUM
gs-4062	216	35	.	.	PUNCT
gs-4062	217	1	strs	strs	PROPN
gs-4062	217	2	revolutionized	revolutionize	VERB
gs-4062	217	3	patient	patient	ADJ
gs-4062	217	4	adherence	adherence	NOUN
gs-4062	217	5	and	and	CCONJ
gs-4062	217	6	convenience	convenience	NOUN
gs-4062	217	7	,	,	PUNCT
gs-4062	217	8	reducing	reduce	VERB
gs-4062	217	9	a	a	DET
gs-4062	217	10	complex	complex	ADJ
gs-4062	217	11	regimen	regiman	NOUN
gs-4062	217	12	to	to	ADP
gs-4062	217	13	a	a	DET
gs-4062	217	14	single	single	ADJ
gs-4062	217	15	daily	daily	ADJ
gs-4062	217	16	pill	pill	NOUN
gs-4062	217	17	.	.	PUNCT
gs-4062	218	1	concurrently	concurrently	ADV
gs-4062	218	2	,	,	PUNCT
gs-4062	218	3	the	the	DET
gs-4062	218	4	strategic	strategic	ADJ
gs-4062	218	5	approach	approach	NOUN
gs-4062	218	6	to	to	ADP
gs-4062	218	7	when	when	SCONJ
gs-4062	218	8	to	to	PART
gs-4062	218	9	start	start	VERB
gs-4062	218	10	therapy	therapy	NOUN
gs-4062	218	11	evolved	evolve	VERB
gs-4062	218	12	significantly	significantly	ADV
gs-4062	218	13	.	.	PUNCT
gs-4062	219	1	initially	initially	ADV
gs-4062	219	2	,	,	PUNCT
gs-4062	219	3	treatment	treatment	NOUN
gs-4062	219	4	was	be	AUX
gs-4062	219	5	reserved	reserve	VERB
gs-4062	219	6	for	for	ADP
gs-4062	219	7	those	those	PRON
gs-4062	219	8	with	with	ADP
gs-4062	219	9	advanced	advanced	ADJ
gs-4062	219	10	immunodeficiency	immunodeficiency	NOUN
gs-4062	219	11	,	,	PUNCT
gs-4062	219	12	due	due	ADP
gs-4062	219	13	to	to	ADP
gs-4062	219	14	the	the	DET
gs-4062	219	15	high	high	ADJ
gs-4062	219	16	toxicity	toxicity	NOUN
gs-4062	219	17	and	and	CCONJ
gs-4062	219	18	complexity	complexity	NOUN
gs-4062	219	19	of	of	ADP
gs-4062	219	20	early	early	ADJ
gs-4062	219	21	drugs	drug	NOUN
gs-4062	219	22	.	.	PUNCT
gs-4062	220	1	as	as	SCONJ
gs-4062	220	2	regimens	regimen	NOUN
gs-4062	220	3	became	become	VERB
gs-4062	220	4	safer	safe	ADJ
gs-4062	220	5	and	and	CCONJ
gs-4062	220	6	simpler	simple	ADJ
gs-4062	220	7	,	,	PUNCT
gs-4062	220	8	evidence	evidence	NOUN
gs-4062	220	9	mounted	mount	VERB
gs-4062	220	10	from	from	ADP
gs-4062	220	11	large	large	ADJ
gs-4062	220	12	randomized	randomized	ADJ
gs-4062	220	13	trials	trial	NOUN
gs-4062	220	14	like	like	ADP
gs-4062	220	15	start	start	VERB
gs-4062	220	16	and	and	CCONJ
gs-4062	220	17	temprano	temprano	VERB
gs-4062	220	18	that	that	SCONJ
gs-4062	220	19	initiating	initiate	VERB
gs-4062	220	20	art	art	NOUN
gs-4062	220	21	immediately	immediately	ADV
gs-4062	220	22	upon	upon	SCONJ
gs-4062	220	23	diagnosis	diagnosis	NOUN
gs-4062	220	24	improved	improve	VERB
gs-4062	220	25	individual	individual	ADJ
gs-4062	220	26	health	health	NOUN
gs-4062	220	27	outcomes	outcome	NOUN
gs-4062	220	28	by	by	ADP
gs-4062	220	29	preserving	preserve	VERB
gs-4062	220	30	immune	immune	ADJ
gs-4062	220	31	function	function	NOUN
gs-4062	220	32	and	and	CCONJ
gs-4062	220	33	reducing	reduce	VERB
gs-4062	220	34	inflammation	inflammation	NOUN
gs-4062	220	35	-	-	PUNCT
gs-4062	220	36	linked	link	VERB
gs-4062	220	37	comorbidities	comorbiditie	NOUN
gs-4062	220	38	.	.	PUNCT
gs-4062	221	1	it	it	PRON
gs-4062	221	2	also	also	ADV
gs-4062	221	3	provided	provide	VERB
gs-4062	221	4	a	a	DET
gs-4062	221	5	powerful	powerful	ADJ
gs-4062	221	6	public	public	ADJ
gs-4062	221	7	health	health	NOUN
gs-4062	221	8	benefit	benefit	NOUN
gs-4062	221	9	:	:	PUNCT
gs-4062	221	10	individuals	individual	NOUN
gs-4062	221	11	with	with	ADP
gs-4062	221	12	an	an	DET
gs-4062	221	13	undetectable	undetectable	ADJ
gs-4062	221	14	viral	viral	ADJ
gs-4062	221	15	load	load	NOUN
gs-4062	221	16	can	can	AUX
gs-4062	221	17	not	not	PART
gs-4062	221	18	sexually	sexually	ADV
gs-4062	221	19	transmit	transmit	VERB
gs-4062	221	20	hiv	hiv	PROPN
gs-4062	221	21	.	.	PUNCT
gs-4062	222	1	this	this	DET
gs-4062	222	2	finding	finding	NOUN
gs-4062	222	3	,	,	PUNCT
gs-4062	222	4	conclusively	conclusively	ADV
gs-4062	222	5	proven	prove	VERB
gs-4062	222	6	by	by	ADP
gs-4062	222	7	the	the	DET
gs-4062	222	8	hptn	hptn	PROPN
gs-4062	222	9	052	052	NUM
gs-4062	222	10	and	and	CCONJ
gs-4062	222	11	partner	partner	NOUN
gs-4062	222	12	studies	study	NOUN
gs-4062	222	13	,	,	PUNCT
gs-4062	222	14	gave	give	VERB
gs-4062	222	15	rise	rise	NOUN
gs-4062	222	16	to	to	ADP
gs-4062	222	17	the	the	DET
gs-4062	222	18	undetectable	undetectable	NOUN
gs-4062	222	19	=	=	SYM
gs-4062	222	20	untransmittable	untransmittable	ADJ
gs-4062	222	21	(	(	PUNCT
gs-4062	222	22	u	u	NOUN
gs-4062	222	23	=	=	NOUN
gs-4062	222	24	u	u	NOUN
gs-4062	222	25	)	)	PUNCT
gs-4062	222	26	campaign	campaign	NOUN
gs-4062	222	27	,	,	PUNCT
gs-4062	222	28	a	a	DET
gs-4062	222	29	transformative	transformative	ADJ
gs-4062	222	30	concept	concept	NOUN
gs-4062	222	31	that	that	PRON
gs-4062	222	32	began	begin	VERB
gs-4062	222	33	to	to	PART
gs-4062	222	34	dismantle	dismantle	VERB
gs-4062	222	35	the	the	DET
gs-4062	222	36	deep	deep	ADV
gs-4062	222	37	-	-	PUNCT
gs-4062	222	38	seated	seat	VERB
gs-4062	222	39	stigma	stigma	NOUN
gs-4062	222	40	associated	associate	VERB
gs-4062	222	41	with	with	ADP
gs-4062	222	42	hiv	hiv	PROPN
gs-4062	222	43	.	.	PUNCT
gs-4062	223	1	despite	despite	SCONJ
gs-4062	223	2	these	these	DET
gs-4062	223	3	monumental	monumental	ADJ
gs-4062	223	4	advances	advance	NOUN
gs-4062	223	5	,	,	PUNCT
gs-4062	223	6	significant	significant	ADJ
gs-4062	223	7	challenges	challenge	NOUN
gs-4062	223	8	persisted	persist	VERB
gs-4062	223	9	as	as	SCONJ
gs-4062	223	10	the	the	DET
gs-4062	223	11	second	second	ADJ
gs-4062	223	12	decade	decade	NOUN
gs-4062	223	13	of	of	ADP
gs-4062	223	14	the	the	DET
gs-4062	223	15	21st	21st	ADJ
gs-4062	223	16	century	century	NOUN
gs-4062	223	17	unfolded	unfold	VERB
gs-4062	223	18	.	.	PUNCT
gs-4062	224	1	while	while	SCONJ
gs-4062	224	2	safer	safe	ADJ
gs-4062	224	3	,	,	PUNCT
gs-4062	224	4	drugs	drug	NOUN
gs-4062	224	5	still	still	ADV
gs-4062	224	6	had	have	VERB
gs-4062	224	7	long	long	ADJ
gs-4062	224	8	-	-	PUNCT
gs-4062	224	9	term	term	NOUN
gs-4062	224	10	toxicities	toxicity	NOUN
gs-4062	224	11	.	.	PUNCT
gs-4062	225	1	tenofovir	tenofovir	NOUN
gs-4062	225	2	disoproxil	disoproxil	VERB
gs-4062	225	3	fumarate	fumarate	NOUN
gs-4062	225	4	(	(	PUNCT
gs-4062	225	5	tdf	tdf	PROPN
gs-4062	225	6	)	)	PUNCT
gs-4062	225	7	,	,	PUNCT
gs-4062	225	8	a	a	DET
gs-4062	225	9	cornerstone	cornerstone	NOUN
gs-4062	225	10	of	of	ADP
gs-4062	225	11	most	most	ADJ
gs-4062	225	12	regimens	regimen	NOUN
gs-4062	225	13	,	,	PUNCT
gs-4062	225	14	was	be	AUX
gs-4062	225	15	associated	associate	VERB
gs-4062	225	16	with	with	ADP
gs-4062	225	17	a	a	DET
gs-4062	225	18	risk	risk	NOUN
gs-4062	225	19	of	of	ADP
gs-4062	225	20	renal	renal	ADJ
gs-4062	225	21	impairment	impairment	NOUN
gs-4062	225	22	and	and	CCONJ
gs-4062	225	23	reduced	reduced	ADJ
gs-4062	225	24	bone	bone	NOUN
gs-4062	225	25	mineral	mineral	NOUN
gs-4062	225	26	density	density	NOUN
gs-4062	225	27	.	.	PUNCT
gs-4062	226	1	adherence	adherence	NOUN
gs-4062	226	2	,	,	PUNCT
gs-4062	226	3	though	though	SCONJ
gs-4062	226	4	improved	improve	VERB
gs-4062	226	5	,	,	PUNCT
gs-4062	226	6	remained	remain	VERB
gs-4062	226	7	a	a	DET
gs-4062	226	8	critical	critical	ADJ
gs-4062	226	9	issue	issue	NOUN
gs-4062	226	10	;	;	PUNCT
gs-4062	226	11	missing	miss	VERB
gs-4062	226	12	doses	dose	NOUN
gs-4062	226	13	of	of	ADP
gs-4062	226	14	certain	certain	ADJ
gs-4062	226	15	drugs	drug	NOUN
gs-4062	226	16	could	could	AUX
gs-4062	226	17	still	still	ADV
gs-4062	226	18	lead	lead	VERB
gs-4062	226	19	to	to	ADP
gs-4062	226	20	virological	virological	ADJ
gs-4062	226	21	failure	failure	NOUN
gs-4062	226	22	and	and	CCONJ
gs-4062	226	23	the	the	DET
gs-4062	226	24	emergence	emergence	NOUN
gs-4062	226	25	of	of	ADP
gs-4062	226	26	resistance	resistance	NOUN
gs-4062	226	27	.	.	PUNCT
gs-4062	227	1	for	for	ADP
gs-4062	227	2	a	a	DET
gs-4062	227	3	small	small	ADJ
gs-4062	227	4	but	but	CCONJ
gs-4062	227	5	significant	significant	ADJ
gs-4062	227	6	population	population	NOUN
gs-4062	227	7	of	of	ADP
gs-4062	227	8	"	"	PUNCT
gs-4062	227	9	treatment	treatment	NOUN
gs-4062	227	10	-	-	PUNCT
gs-4062	227	11	experienced	experienced	ADJ
gs-4062	227	12	"	"	PUNCT
gs-4062	227	13	patients	patient	NOUN
gs-4062	227	14	,	,	PUNCT
gs-4062	227	15	the	the	DET
gs-4062	227	16	virus	virus	NOUN
gs-4062	227	17	had	have	AUX
gs-4062	227	18	developed	develop	VERB
gs-4062	227	19	resistance	resistance	NOUN
gs-4062	227	20	to	to	ADP
gs-4062	227	21	multiple	multiple	ADJ
gs-4062	227	22	drug	drug	NOUN
gs-4062	227	23	classes	class	NOUN
gs-4062	227	24	,	,	PUNCT
gs-4062	227	25	leaving	leave	VERB
gs-4062	227	26	them	they	PRON
gs-4062	227	27	with	with	ADP
gs-4062	227	28	few	few	ADJ
gs-4062	227	29	,	,	PUNCT
gs-4062	227	30	complex	complex	ADJ
gs-4062	227	31	,	,	PUNCT
gs-4062	227	32	and	and	CCONJ
gs-4062	227	33	often	often	ADV
gs-4062	227	34	suboptimal	suboptimal	ADJ
gs-4062	227	35	salvage	salvage	NOUN
gs-4062	227	36	options	option	NOUN
gs-4062	227	37	.	.	PUNCT
gs-4062	228	1	furthermore	furthermore	ADV
gs-4062	228	2	,	,	PUNCT
gs-4062	228	3	the	the	DET
gs-4062	228	4	psychological	psychological	ADJ
gs-4062	228	5	burden	burden	NOUN
gs-4062	228	6	of	of	ADP
gs-4062	228	7	a	a	DET
gs-4062	228	8	lifelong	lifelong	ADJ
gs-4062	228	9	daily	daily	ADJ
gs-4062	228	10	reminder	reminder	NOUN
gs-4062	228	11	of	of	ADP
gs-4062	228	12	one	one	NUM
gs-4062	228	13	's	's	PART
gs-4062	228	14	hiv	hiv	PROPN
gs-4062	228	15	status	status	NOUN
gs-4062	228	16	—	—	PUNCT
gs-4062	228	17	taking	take	VERB
gs-4062	228	18	a	a	DET
gs-4062	228	19	pill	pill	NOUN
gs-4062	228	20	every	every	DET
gs-4062	228	21	day	day	NOUN
gs-4062	228	22	—	—	PUNCT
gs-4062	228	23	remained	remain	VERB
gs-4062	228	24	a	a	DET
gs-4062	228	25	source	source	NOUN
gs-4062	228	26	of	of	ADP
gs-4062	228	27	stigma	stigma	NOUN
gs-4062	228	28	for	for	ADP
gs-4062	228	29	some	some	PRON
gs-4062	228	30	.	.	PUNCT
gs-4062	229	1	it	it	PRON
gs-4062	229	2	is	be	AUX
gs-4062	229	3	within	within	ADP
gs-4062	229	4	this	this	DET
gs-4062	229	5	context	context	NOUN
gs-4062	229	6	of	of	ADP
gs-4062	229	7	both	both	CCONJ
gs-4062	229	8	triumph	triumph	NOUN
gs-4062	229	9	and	and	CCONJ
gs-4062	229	10	lingering	linger	VERB
gs-4062	229	11	challenge	challenge	NOUN
gs-4062	229	12	that	that	PRON
gs-4062	229	13	the	the	DET
gs-4062	229	14	latest	late	ADJ
gs-4062	229	15	revolution	revolution	NOUN
gs-4062	229	16	in	in	ADP
gs-4062	229	17	antiretroviral	antiretroviral	ADJ
gs-4062	229	18	therapy	therapy	NOUN
gs-4062	229	19	is	be	AUX
gs-4062	229	20	taking	take	VERB
gs-4062	229	21	place	place	NOUN
gs-4062	229	22	.	.	PUNCT
gs-4062	230	1	the	the	DET
gs-4062	230	2	newest	new	ADJ
gs-4062	230	3	generation	generation	NOUN
gs-4062	230	4	of	of	ADP
gs-4062	230	5	drugs	drug	NOUN
gs-4062	230	6	is	be	AUX
gs-4062	230	7	not	not	PART
gs-4062	230	8	merely	merely	ADV
gs-4062	230	9	an	an	DET
gs-4062	230	10	georgian	georgian	NOUN
gs-4062	230	11	scientists/	scientists/	NUM
gs-4062	230	12	.	.	PUNCT
gs-4062	231	1	7	7	NUM
gs-4062	231	2	n	n	PRON
gs-4062	231	3	3	3	NUM
gs-4062	231	4	,	,	PUNCT
gs-4062	231	5	2025	2025	NUM
gs-4062	231	6	532	532	NUM
gs-4062	231	7	incremental	incremental	ADJ
gs-4062	231	8	improvement	improvement	NOUN
gs-4062	231	9	but	but	CCONJ
gs-4062	231	10	a	a	DET
gs-4062	231	11	fundamental	fundamental	ADJ
gs-4062	231	12	re	re	NOUN
gs-4062	231	13	-	-	NOUN
gs-4062	231	14	imagining	imagine	VERB
gs-4062	231	15	of	of	ADP
gs-4062	231	16	what	what	PRON
gs-4062	231	17	hiv	hiv	NOUN
gs-4062	231	18	treatment	treatment	NOUN
gs-4062	231	19	can	can	AUX
gs-4062	231	20	be	be	AUX
gs-4062	231	21	.	.	PUNCT
gs-4062	232	1	they	they	PRON
gs-4062	232	2	are	be	AUX
gs-4062	232	3	the	the	DET
gs-4062	232	4	products	product	NOUN
gs-4062	232	5	of	of	ADP
gs-4062	232	6	decades	decade	NOUN
gs-4062	232	7	of	of	ADP
gs-4062	232	8	accumulated	accumulate	VERB
gs-4062	232	9	virological	virological	ADJ
gs-4062	232	10	knowledge	knowledge	NOUN
gs-4062	232	11	,	,	PUNCT
gs-4062	232	12	medicinal	medicinal	ADJ
gs-4062	232	13	chemistry	chemistry	NOUN
gs-4062	232	14	,	,	PUNCT
gs-4062	232	15	and	and	CCONJ
gs-4062	232	16	pharmacological	pharmacological	ADJ
gs-4062	232	17	insight	insight	NOUN
gs-4062	232	18	,	,	PUNCT
gs-4062	232	19	designed	design	VERB
gs-4062	232	20	to	to	PART
gs-4062	232	21	address	address	VERB
gs-4062	232	22	the	the	DET
gs-4062	232	23	specific	specific	ADJ
gs-4062	232	24	shortcomings	shortcoming	NOUN
gs-4062	232	25	of	of	ADP
gs-4062	232	26	their	their	PRON
gs-4062	232	27	predecessors	predecessor	NOUN
gs-4062	232	28	.	.	PUNCT
gs-4062	233	1	this	this	DET
gs-4062	233	2	new	new	ADJ
gs-4062	233	3	era	era	NOUN
gs-4062	233	4	is	be	AUX
gs-4062	233	5	defined	define	VERB
gs-4062	233	6	by	by	ADP
gs-4062	233	7	several	several	ADJ
gs-4062	233	8	key	key	ADJ
gs-4062	233	9	themes	theme	NOUN
gs-4062	233	10	:	:	PUNCT
gs-4062	233	11	the	the	DET
gs-4062	233	12	pursuit	pursuit	NOUN
gs-4062	233	13	of	of	ADP
gs-4062	233	14	unmatched	unmatched	ADJ
gs-4062	233	15	potency	potency	NOUN
gs-4062	233	16	and	and	CCONJ
gs-4062	233	17	genetic	genetic	ADJ
gs-4062	233	18	barrier	barrier	NOUN
gs-4062	233	19	to	to	ADP
gs-4062	233	20	resistance	resistance	NOUN
gs-4062	233	21	;	;	PUNCT
gs-4062	233	22	the	the	DET
gs-4062	233	23	optimization	optimization	NOUN
gs-4062	233	24	of	of	ADP
gs-4062	233	25	long	long	ADJ
gs-4062	233	26	-	-	PUNCT
gs-4062	233	27	term	term	NOUN
gs-4062	233	28	safety	safety	NOUN
gs-4062	233	29	and	and	CCONJ
gs-4062	233	30	tolerability	tolerability	NOUN
gs-4062	233	31	;	;	PUNCT
gs-4062	233	32	the	the	DET
gs-4062	233	33	introduction	introduction	NOUN
gs-4062	233	34	of	of	ADP
gs-4062	233	35	ultra	ultra	ADJ
gs-4062	233	36	-	-	ADJ
gs-4062	233	37	longacting	longacting	ADJ
gs-4062	233	38	formulations	formulation	NOUN
gs-4062	233	39	that	that	PRON
gs-4062	233	40	decouple	decouple	VERB
gs-4062	233	41	treatment	treatment	NOUN
gs-4062	233	42	from	from	ADP
gs-4062	233	43	daily	daily	ADJ
gs-4062	233	44	life	life	NOUN
gs-4062	233	45	;	;	PUNCT
gs-4062	233	46	and	and	CCONJ
gs-4062	233	47	the	the	DET
gs-4062	233	48	exploration	exploration	NOUN
gs-4062	233	49	of	of	ADP
gs-4062	233	50	novel	novel	ADJ
gs-4062	233	51	mechanisms	mechanism	NOUN
gs-4062	233	52	of	of	ADP
gs-4062	233	53	action	action	NOUN
gs-4062	233	54	that	that	PRON
gs-4062	233	55	attack	attack	VERB
gs-4062	233	56	the	the	DET
gs-4062	233	57	virus	virus	NOUN
gs-4062	233	58	in	in	ADP
gs-4062	233	59	previously	previously	ADV
gs-4062	233	60	untargeted	untargete	VERB
gs-4062	233	61	ways	way	NOUN
gs-4062	233	62	.	.	PUNCT
gs-4062	234	1	furthermore	furthermore	ADV
gs-4062	234	2	,	,	PUNCT
gs-4062	234	3	the	the	DET
gs-4062	234	4	scientific	scientific	ADJ
gs-4062	234	5	community	community	NOUN
gs-4062	234	6	is	be	AUX
gs-4062	234	7	now	now	ADV
gs-4062	234	8	,	,	PUNCT
gs-4062	234	9	for	for	ADP
gs-4062	234	10	the	the	DET
gs-4062	234	11	first	first	ADJ
gs-4062	234	12	time	time	NOUN
gs-4062	234	13	,	,	PUNCT
gs-4062	234	14	seriously	seriously	ADV
gs-4062	234	15	pursuing	pursue	VERB
gs-4062	234	16	strategies	strategy	NOUN
gs-4062	234	17	aimed	aim	VERB
gs-4062	234	18	not	not	PART
gs-4062	234	19	just	just	ADV
gs-4062	234	20	at	at	ADP
gs-4062	234	21	chronic	chronic	ADJ
gs-4062	234	22	suppression	suppression	NOUN
gs-4062	234	23	,	,	PUNCT
gs-4062	234	24	but	but	CCONJ
gs-4062	234	25	at	at	ADP
gs-4062	234	26	a	a	DET
gs-4062	234	27	functional	functional	ADJ
gs-4062	234	28	cure	cure	NOUN
gs-4062	234	29	.	.	PUNCT
gs-4062	235	1	this	this	DET
gs-4062	235	2	background	background	NOUN
gs-4062	235	3	of	of	ADP
gs-4062	235	4	struggle	struggle	NOUN
gs-4062	235	5	,	,	PUNCT
gs-4062	235	6	innovation	innovation	NOUN
gs-4062	235	7	,	,	PUNCT
gs-4062	235	8	and	and	CCONJ
gs-4062	235	9	evolving	evolve	VERB
gs-4062	235	10	challenges	challenge	NOUN
gs-4062	235	11	sets	set	VERB
gs-4062	235	12	the	the	DET
gs-4062	235	13	stage	stage	NOUN
gs-4062	235	14	for	for	ADP
gs-4062	235	15	the	the	DET
gs-4062	235	16	groundbreaking	groundbreake	VERB
gs-4062	235	17	developments	development	NOUN
gs-4062	235	18	in	in	ADP
gs-4062	235	19	classification	classification	NOUN
gs-4062	235	20	,	,	PUNCT
gs-4062	235	21	mechanism	mechanism	NOUN
gs-4062	235	22	,	,	PUNCT
gs-4062	235	23	pharmacology	pharmacology	NOUN
gs-4062	235	24	,	,	PUNCT
gs-4062	235	25	and	and	CCONJ
gs-4062	235	26	clinical	clinical	ADJ
gs-4062	235	27	application	application	NOUN
gs-4062	235	28	that	that	PRON
gs-4062	235	29	will	will	AUX
gs-4062	235	30	be	be	AUX
gs-4062	235	31	explored	explore	VERB
gs-4062	235	32	in	in	ADP
gs-4062	235	33	the	the	DET
gs-4062	235	34	subsequent	subsequent	ADJ
gs-4062	235	35	sections	section	NOUN
gs-4062	235	36	of	of	ADP
gs-4062	235	37	this	this	DET
gs-4062	235	38	work	work	NOUN
gs-4062	235	39	.	.	PUNCT
gs-4062	236	1	the	the	DET
gs-4062	236	2	journey	journey	NOUN
gs-4062	236	3	from	from	ADP
gs-4062	236	4	a	a	DET
gs-4062	236	5	certain	certain	ADJ
gs-4062	236	6	death	death	NOUN
gs-4062	236	7	sentence	sentence	NOUN
gs-4062	236	8	to	to	ADP
gs-4062	236	9	a	a	DET
gs-4062	236	10	manageable	manageable	ADJ
gs-4062	236	11	chronic	chronic	ADJ
gs-4062	236	12	illness	illness	NOUN
gs-4062	236	13	is	be	AUX
gs-4062	236	14	complete	complete	ADJ
gs-4062	236	15	;	;	PUNCT
gs-4062	236	16	the	the	DET
gs-4062	236	17	journey	journey	NOUN
gs-4062	236	18	from	from	ADP
gs-4062	236	19	chronic	chronic	ADJ
gs-4062	236	20	illness	illness	NOUN
gs-4062	236	21	to	to	ADP
gs-4062	236	22	a	a	DET
gs-4062	236	23	life	life	NOUN
gs-4062	236	24	completely	completely	ADV
gs-4062	236	25	unencumbered	unencumbered	ADJ
gs-4062	236	26	by	by	ADP
gs-4062	236	27	hiv	hiv	PROPN
gs-4062	236	28	is	be	AUX
gs-4062	236	29	now	now	ADV
gs-4062	236	30	underway	underway	ADJ
gs-4062	236	31	.	.	PUNCT
gs-4062	237	1	results	result	NOUN
gs-4062	237	2	and	and	CCONJ
gs-4062	237	3	discussion	discussion	VERB
gs-4062	237	4	the	the	DET
gs-4062	237	5	investigation	investigation	NOUN
gs-4062	237	6	into	into	ADP
gs-4062	237	7	the	the	DET
gs-4062	237	8	latest	late	ADJ
gs-4062	237	9	generation	generation	NOUN
gs-4062	237	10	of	of	ADP
gs-4062	237	11	antiretroviral	antiretroviral	ADJ
gs-4062	237	12	therapeutics	therapeutic	NOUN
gs-4062	237	13	reveals	reveal	VERB
gs-4062	237	14	a	a	DET
gs-4062	237	15	period	period	NOUN
gs-4062	237	16	of	of	ADP
gs-4062	237	17	remarkable	remarkable	ADJ
gs-4062	237	18	innovation	innovation	NOUN
gs-4062	237	19	and	and	CCONJ
gs-4062	237	20	refinement	refinement	NOUN
gs-4062	237	21	,	,	PUNCT
gs-4062	237	22	fundamentally	fundamentally	ADV
gs-4062	237	23	altering	alter	VERB
gs-4062	237	24	the	the	DET
gs-4062	237	25	clinical	clinical	ADJ
gs-4062	237	26	management	management	NOUN
gs-4062	237	27	of	of	ADP
gs-4062	237	28	human	human	ADJ
gs-4062	237	29	immunodeficiency	immunodeficiency	NOUN
gs-4062	237	30	virus	virus	NOUN
gs-4062	237	31	infection	infection	NOUN
gs-4062	237	32	.	.	PUNCT
gs-4062	238	1	the	the	DET
gs-4062	238	2	results	result	NOUN
gs-4062	238	3	from	from	ADP
gs-4062	238	4	a	a	DET
gs-4062	238	5	synthesis	synthesis	NOUN
gs-4062	238	6	of	of	ADP
gs-4062	238	7	recent	recent	ADJ
gs-4062	238	8	clinical	clinical	ADJ
gs-4062	238	9	trials	trial	NOUN
gs-4062	238	10	,	,	PUNCT
gs-4062	238	11	pharmacological	pharmacological	ADJ
gs-4062	238	12	studies	study	NOUN
gs-4062	238	13	,	,	PUNCT
gs-4062	238	14	and	and	CCONJ
gs-4062	238	15	real	real	ADJ
gs-4062	238	16	-	-	PUNCT
gs-4062	238	17	world	world	NOUN
gs-4062	238	18	evidence	evidence	NOUN
gs-4062	238	19	datasets	dataset	NOUN
gs-4062	238	20	paint	paint	VERB
gs-4062	238	21	a	a	DET
gs-4062	238	22	picture	picture	NOUN
gs-4062	238	23	of	of	ADP
gs-4062	238	24	a	a	DET
gs-4062	238	25	field	field	NOUN
gs-4062	238	26	that	that	PRON
gs-4062	238	27	has	have	AUX
gs-4062	238	28	successfully	successfully	ADV
gs-4062	238	29	transitioned	transition	VERB
gs-4062	238	30	from	from	ADP
gs-4062	238	31	a	a	DET
gs-4062	238	32	focus	focus	NOUN
gs-4062	238	33	on	on	ADP
gs-4062	238	34	sheer	sheer	ADJ
gs-4062	238	35	survival	survival	NOUN
gs-4062	238	36	to	to	ADP
gs-4062	238	37	an	an	DET
gs-4062	238	38	emphasis	emphasis	NOUN
gs-4062	238	39	on	on	ADP
gs-4062	238	40	long	long	ADJ
gs-4062	238	41	-	-	PUNCT
gs-4062	238	42	term	term	NOUN
gs-4062	238	43	quality	quality	NOUN
gs-4062	238	44	of	of	ADP
gs-4062	238	45	life	life	NOUN
gs-4062	238	46	,	,	PUNCT
gs-4062	238	47	safety	safety	NOUN
gs-4062	238	48	,	,	PUNCT
gs-4062	238	49	and	and	CCONJ
gs-4062	238	50	strategic	strategic	ADJ
gs-4062	238	51	viral	viral	ADJ
gs-4062	238	52	suppression	suppression	NOUN
gs-4062	238	53	.	.	PUNCT
gs-4062	239	1	this	this	DET
gs-4062	239	2	discussion	discussion	NOUN
gs-4062	239	3	will	will	AUX
gs-4062	239	4	integrate	integrate	VERB
gs-4062	239	5	these	these	DET
gs-4062	239	6	findings	finding	NOUN
gs-4062	239	7	,	,	PUNCT
gs-4062	239	8	exploring	explore	VERB
gs-4062	239	9	the	the	DET
gs-4062	239	10	tangible	tangible	ADJ
gs-4062	239	11	outcomes	outcome	NOUN
gs-4062	239	12	linked	link	VERB
gs-4062	239	13	to	to	ADP
gs-4062	239	14	the	the	DET
gs-4062	239	15	novel	novel	ADJ
gs-4062	239	16	mechanisms	mechanism	NOUN
gs-4062	239	17	of	of	ADP
gs-4062	239	18	action	action	NOUN
gs-4062	239	19	,	,	PUNCT
gs-4062	239	20	superior	superior	ADJ
gs-4062	239	21	pharmacological	pharmacological	ADJ
gs-4062	239	22	profiles	profile	NOUN
gs-4062	239	23	,	,	PUNCT
gs-4062	239	24	and	and	CCONJ
gs-4062	239	25	enhanced	enhance	VERB
gs-4062	239	26	clinical	clinical	ADJ
gs-4062	239	27	efficacy	efficacy	NOUN
gs-4062	239	28	of	of	ADP
gs-4062	239	29	these	these	DET
gs-4062	239	30	agents	agent	NOUN
gs-4062	239	31	,	,	PUNCT
gs-4062	239	32	while	while	SCONJ
gs-4062	239	33	also	also	ADV
gs-4062	239	34	providing	provide	VERB
gs-4062	239	35	a	a	DET
gs-4062	239	36	critical	critical	ADJ
gs-4062	239	37	appraisal	appraisal	NOUN
gs-4062	239	38	of	of	ADP
gs-4062	239	39	the	the	DET
gs-4062	239	40	emerging	emerge	VERB
gs-4062	239	41	safety	safety	NOUN
gs-4062	239	42	signals	signal	NOUN
gs-4062	239	43	and	and	CCONJ
gs-4062	239	44	the	the	DET
gs-4062	239	45	practical	practical	ADJ
gs-4062	239	46	implications	implication	NOUN
gs-4062	239	47	for	for	ADP
gs-4062	239	48	global	global	ADJ
gs-4062	239	49	treatment	treatment	NOUN
gs-4062	239	50	paradigms	paradigm	NOUN
gs-4062	239	51	.	.	PUNCT
gs-4062	240	1	the	the	DET
gs-4062	240	2	most	most	ADV
gs-4062	240	3	profound	profound	ADJ
gs-4062	240	4	results	result	NOUN
gs-4062	240	5	in	in	ADP
gs-4062	240	6	recent	recent	ADJ
gs-4062	240	7	years	year	NOUN
gs-4062	240	8	have	have	AUX
gs-4062	240	9	emerged	emerge	VERB
gs-4062	240	10	from	from	ADP
gs-4062	240	11	the	the	DET
gs-4062	240	12	continued	continue	VERB
gs-4062	240	13	evolution	evolution	NOUN
gs-4062	240	14	of	of	ADP
gs-4062	240	15	the	the	DET
gs-4062	240	16	integrase	integrase	NOUN
gs-4062	240	17	strand	strand	NOUN
gs-4062	240	18	transfer	transfer	NOUN
gs-4062	240	19	inhibitor	inhibitor	NOUN
gs-4062	240	20	class	class	NOUN
gs-4062	240	21	.	.	PUNCT
gs-4062	241	1	while	while	SCONJ
gs-4062	241	2	first	first	ADJ
gs-4062	241	3	-	-	PUNCT
gs-4062	241	4	generation	generation	NOUN
gs-4062	241	5	instis	instis	NOUN
gs-4062	241	6	like	like	ADP
gs-4062	241	7	raltegravir	raltegravir	PROPN
gs-4062	241	8	and	and	CCONJ
gs-4062	241	9	elvitegravir	elvitegravir	PROPN
gs-4062	241	10	provided	provide	VERB
gs-4062	241	11	potent	potent	ADJ
gs-4062	241	12	suppression	suppression	NOUN
gs-4062	241	13	,	,	PUNCT
gs-4062	241	14	their	their	PRON
gs-4062	241	15	vulnerability	vulnerability	NOUN
gs-4062	241	16	to	to	ADP
gs-4062	241	17	resistance	resistance	NOUN
gs-4062	241	18	mutations	mutation	NOUN
gs-4062	241	19	,	,	PUNCT
gs-4062	241	20	particularly	particularly	ADV
gs-4062	241	21	in	in	ADP
gs-4062	241	22	scenarios	scenario	NOUN
gs-4062	241	23	of	of	ADP
gs-4062	241	24	suboptimal	suboptimal	ADJ
gs-4062	241	25	adherence	adherence	NOUN
gs-4062	241	26	,	,	PUNCT
gs-4062	241	27	presented	present	VERB
gs-4062	241	28	a	a	DET
gs-4062	241	29	clinical	clinical	ADJ
gs-4062	241	30	limitation	limitation	NOUN
gs-4062	241	31	.	.	PUNCT
gs-4062	242	1	the	the	DET
gs-4062	242	2	introduction	introduction	NOUN
gs-4062	242	3	and	and	CCONJ
gs-4062	242	4	widespread	widespread	ADJ
gs-4062	242	5	adoption	adoption	NOUN
gs-4062	242	6	of	of	ADP
gs-4062	242	7	second	second	ADJ
gs-4062	242	8	-	-	PUNCT
gs-4062	242	9	generation	generation	NOUN
gs-4062	242	10	instis	instis	NOUN
gs-4062	242	11	,	,	PUNCT
gs-4062	242	12	namely	namely	ADV
gs-4062	242	13	dolutegravir	dolutegravir	PROPN
gs-4062	242	14	and	and	CCONJ
gs-4062	242	15	bictegravir	bictegravir	PROPN
gs-4062	242	16	,	,	PUNCT
gs-4062	242	17	have	have	AUX
gs-4062	242	18	yielded	yield	VERB
gs-4062	242	19	results	result	NOUN
gs-4062	242	20	that	that	PRON
gs-4062	242	21	signify	signify	VERB
gs-4062	242	22	a	a	DET
gs-4062	242	23	paradigm	paradigm	NOUN
gs-4062	242	24	shift	shift	NOUN
gs-4062	242	25	.	.	PUNCT
gs-4062	243	1	clinical	clinical	ADJ
gs-4062	243	2	endpoint	endpoint	NOUN
gs-4062	243	3	studies	study	NOUN
gs-4062	243	4	consistently	consistently	ADV
gs-4062	243	5	demonstrate	demonstrate	VERB
gs-4062	243	6	that	that	SCONJ
gs-4062	243	7	regimens	regimen	NOUN
gs-4062	243	8	anchored	anchor	VERB
gs-4062	243	9	by	by	ADP
gs-4062	243	10	these	these	DET
gs-4062	243	11	agents	agent	NOUN
gs-4062	243	12	achieve	achieve	VERB
gs-4062	243	13	rates	rate	NOUN
gs-4062	243	14	of	of	ADP
gs-4062	243	15	virological	virological	ADJ
gs-4062	243	16	suppression	suppression	NOUN
gs-4062	243	17	that	that	PRON
gs-4062	243	18	are	be	AUX
gs-4062	243	19	non	non	ADJ
gs-4062	243	20	-	-	ADJ
gs-4062	243	21	inferior	inferior	ADJ
gs-4062	243	22	,	,	PUNCT
gs-4062	243	23	and	and	CCONJ
gs-4062	243	24	in	in	ADP
gs-4062	243	25	some	some	DET
gs-4062	243	26	high	high	ADJ
gs-4062	243	27	-	-	PUNCT
gs-4062	243	28	risk	risk	NOUN
gs-4062	243	29	populations	population	NOUN
gs-4062	243	30	,	,	PUNCT
gs-4062	243	31	superior	superior	ADJ
gs-4062	243	32	,	,	PUNCT
gs-4062	243	33	to	to	ADP
gs-4062	243	34	the	the	DET
gs-4062	243	35	previous	previous	ADJ
gs-4062	243	36	gold	gold	NOUN
gs-4062	243	37	standards	standard	NOUN
gs-4062	243	38	.	.	PUNCT
gs-4062	244	1	the	the	DET
gs-4062	244	2	defining	define	VERB
gs-4062	244	3	result	result	NOUN
gs-4062	244	4	for	for	ADP
gs-4062	244	5	dolutegravir	dolutegravir	NOUN
gs-4062	244	6	has	have	AUX
gs-4062	244	7	been	be	AUX
gs-4062	244	8	its	its	PRON
gs-4062	244	9	exceptionally	exceptionally	ADV
gs-4062	244	10	high	high	ADJ
gs-4062	244	11	genetic	genetic	ADJ
gs-4062	244	12	barrier	barrier	NOUN
gs-4062	244	13	to	to	ADP
gs-4062	244	14	resistance	resistance	NOUN
gs-4062	244	15	;	;	PUNCT
gs-4062	244	16	treatment	treatment	NOUN
gs-4062	244	17	-	-	PUNCT
gs-4062	244	18	naïve	naïve	ADJ
gs-4062	244	19	patients	patient	NOUN
gs-4062	244	20	receiving	receive	VERB
gs-4062	244	21	dolutegravir	dolutegravir	NOUN
gs-4062	244	22	-	-	PUNCT
gs-4062	244	23	based	base	VERB
gs-4062	244	24	therapy	therapy	NOUN
gs-4062	244	25	exhibit	exhibit	VERB
gs-4062	244	26	an	an	DET
gs-4062	244	27	almost	almost	ADV
gs-4062	244	28	negligible	negligible	ADJ
gs-4062	244	29	incidence	incidence	NOUN
gs-4062	244	30	of	of	ADP
gs-4062	244	31	virological	virological	ADJ
gs-4062	244	32	failure	failure	NOUN
gs-4062	244	33	with	with	ADP
gs-4062	244	34	emergent	emergent	ADJ
gs-4062	244	35	insti	insti	NOUN
gs-4062	244	36	resistance	resistance	NOUN
gs-4062	244	37	mutations	mutation	NOUN
gs-4062	244	38	.	.	PUNCT
gs-4062	245	1	this	this	PRON
gs-4062	245	2	is	be	AUX
gs-4062	245	3	a	a	DET
gs-4062	245	4	direct	direct	ADJ
gs-4062	245	5	consequence	consequence	NOUN
gs-4062	245	6	of	of	ADP
gs-4062	245	7	its	its	PRON
gs-4062	245	8	unique	unique	ADJ
gs-4062	245	9	pharmacodynamic	pharmacodynamic	ADJ
gs-4062	245	10	properties	property	NOUN
gs-4062	245	11	,	,	PUNCT
gs-4062	245	12	specifically	specifically	ADV
gs-4062	245	13	its	its	PRON
gs-4062	245	14	slow	slow	ADJ
gs-4062	245	15	dissociation	dissociation	NOUN
gs-4062	245	16	rate	rate	NOUN
gs-4062	245	17	from	from	ADP
gs-4062	245	18	the	the	DET
gs-4062	245	19	integrase	integrase	NOUN
gs-4062	245	20	enzyme	enzyme	NOUN
gs-4062	245	21	complex	complex	NOUN
gs-4062	245	22	,	,	PUNCT
gs-4062	245	23	which	which	PRON
gs-4062	245	24	means	mean	VERB
gs-4062	245	25	that	that	SCONJ
gs-4062	245	26	even	even	ADV
gs-4062	245	27	if	if	SCONJ
gs-4062	245	28	a	a	DET
gs-4062	245	29	mutation	mutation	NOUN
gs-4062	245	30	occurs	occur	VERB
gs-4062	245	31	that	that	PRON
gs-4062	245	32	slightly	slightly	ADV
gs-4062	245	33	weakens	weaken	VERB
gs-4062	245	34	the	the	DET
gs-4062	245	35	binding	bind	VERB
gs-4062	245	36	affinity	affinity	NOUN
gs-4062	245	37	,	,	PUNCT
gs-4062	245	38	the	the	DET
gs-4062	245	39	drug	drug	NOUN
gs-4062	245	40	remains	remain	VERB
gs-4062	245	41	bound	bind	VERB
gs-4062	245	42	long	long	ADV
gs-4062	245	43	enough	enough	ADV
gs-4062	245	44	to	to	PART
gs-4062	245	45	exert	exert	VERB
gs-4062	245	46	its	its	PRON
gs-4062	245	47	inhibitory	inhibitory	ADJ
gs-4062	245	48	effect	effect	NOUN
gs-4062	245	49	.	.	PUNCT
gs-4062	246	1	this	this	DET
gs-4062	246	2	result	result	NOUN
gs-4062	246	3	has	have	VERB
gs-4062	246	4	monumental	monumental	ADJ
gs-4062	246	5	implications	implication	NOUN
gs-4062	246	6	for	for	ADP
gs-4062	246	7	global	global	ADJ
gs-4062	246	8	health	health	NOUN
gs-4062	246	9	,	,	PUNCT
gs-4062	246	10	offering	offer	VERB
gs-4062	246	11	a	a	DET
gs-4062	246	12	more	more	ADV
gs-4062	246	13	forgiving	forgiving	ADJ
gs-4062	246	14	and	and	CCONJ
gs-4062	246	15	robust	robust	ADJ
gs-4062	246	16	platform	platform	NOUN
gs-4062	246	17	for	for	ADP
gs-4062	246	18	treatment	treatment	NOUN
gs-4062	246	19	,	,	PUNCT
gs-4062	246	20	particularly	particularly	ADV
gs-4062	246	21	in	in	ADP
gs-4062	246	22	resource	resource	NOUN
gs-4062	246	23	-	-	PUNCT
gs-4062	246	24	limited	limit	VERB
gs-4062	246	25	settings	setting	NOUN
gs-4062	246	26	with	with	ADP
gs-4062	246	27	limited	limited	ADJ
gs-4062	246	28	options	option	NOUN
gs-4062	246	29	for	for	ADP
gs-4062	246	30	genotypic	genotypic	ADJ
gs-4062	246	31	resistance	resistance	NOUN
gs-4062	246	32	testing	testing	NOUN
gs-4062	246	33	.	.	PUNCT
gs-4062	247	1	parallel	parallel	ADJ
gs-4062	247	2	to	to	ADP
gs-4062	247	3	these	these	DET
gs-4062	247	4	advances	advance	NOUN
gs-4062	247	5	in	in	ADP
gs-4062	247	6	efficacy	efficacy	NOUN
gs-4062	247	7	,	,	PUNCT
gs-4062	247	8	the	the	DET
gs-4062	247	9	pharmacological	pharmacological	ADJ
gs-4062	247	10	optimization	optimization	NOUN
gs-4062	247	11	of	of	ADP
gs-4062	247	12	drug	drug	NOUN
gs-4062	247	13	formulations	formulation	NOUN
gs-4062	247	14	has	have	AUX
gs-4062	247	15	yielded	yield	VERB
gs-4062	247	16	results	result	NOUN
gs-4062	247	17	with	with	ADP
gs-4062	247	18	direct	direct	ADJ
gs-4062	247	19	impacts	impact	NOUN
gs-4062	247	20	on	on	ADP
gs-4062	247	21	patient	patient	ADJ
gs-4062	247	22	safety	safety	NOUN
gs-4062	247	23	and	and	CCONJ
gs-4062	247	24	adherence	adherence	NOUN
gs-4062	247	25	.	.	PUNCT
gs-4062	248	1	the	the	DET
gs-4062	248	2	development	development	NOUN
gs-4062	248	3	of	of	ADP
gs-4062	248	4	tenofovir	tenofovir	PROPN
gs-4062	248	5	alafenamide	alafenamide	PROPN
gs-4062	248	6	as	as	ADP
gs-4062	248	7	a	a	DET
gs-4062	248	8	successor	successor	NOUN
gs-4062	248	9	to	to	PART
gs-4062	248	10	tenofovir	tenofovir	NOUN
gs-4062	248	11	disoproxil	disoproxil	VERB
gs-4062	248	12	fumarate	fumarate	NOUN
gs-4062	248	13	stands	stand	VERB
gs-4062	248	14	as	as	ADP
gs-4062	248	15	a	a	DET
gs-4062	248	16	georgian	georgian	NOUN
gs-4062	248	17	scientists/	scientists/	NUM
gs-4062	248	18	.	.	PUNCT
gs-4062	249	1	7	7	NUM
gs-4062	249	2	n	n	PRON
gs-4062	249	3	3	3	NUM
gs-4062	249	4	,	,	PUNCT
gs-4062	249	5	2025	2025	NUM
gs-4062	249	6	533	533	NUM
gs-4062	249	7	landmark	landmark	ADJ
gs-4062	249	8	achievement	achievement	NOUN
gs-4062	249	9	in	in	ADP
gs-4062	249	10	prodrug	prodrug	NOUN
gs-4062	249	11	chemistry	chemistry	NOUN
gs-4062	249	12	.	.	PUNCT
gs-4062	250	1	the	the	DET
gs-4062	250	2	results	result	NOUN
gs-4062	250	3	of	of	ADP
gs-4062	250	4	large	large	ADJ
gs-4062	250	5	-	-	PUNCT
gs-4062	250	6	scale	scale	NOUN
gs-4062	250	7	,	,	PUNCT
gs-4062	250	8	randomized	randomize	VERB
gs-4062	250	9	controlled	control	VERB
gs-4062	250	10	trials	trial	NOUN
gs-4062	250	11	and	and	CCONJ
gs-4062	250	12	subsequent	subsequent	ADJ
gs-4062	250	13	cohort	cohort	NOUN
gs-4062	250	14	studies	study	NOUN
gs-4062	250	15	are	be	AUX
gs-4062	250	16	unequivocal	unequivocal	ADJ
gs-4062	250	17	:	:	PUNCT
gs-4062	250	18	taf	taf	X
gs-4062	250	19	-	-	PUNCT
gs-4062	250	20	based	base	VERB
gs-4062	250	21	regimens	regimen	NOUN
gs-4062	250	22	provide	provide	VERB
gs-4062	250	23	equivalent	equivalent	ADJ
gs-4062	250	24	antiviral	antiviral	ADJ
gs-4062	250	25	efficacy	efficacy	NOUN
gs-4062	250	26	to	to	ADP
gs-4062	250	27	tdf	tdf	PROPN
gs-4062	250	28	-	-	PUNCT
gs-4062	250	29	based	base	VERB
gs-4062	250	30	regimens	regimen	NOUN
gs-4062	250	31	but	but	CCONJ
gs-4062	250	32	with	with	ADP
gs-4062	250	33	dramatically	dramatically	ADV
gs-4062	250	34	reduced	reduce	VERB
gs-4062	250	35	markers	marker	NOUN
gs-4062	250	36	of	of	ADP
gs-4062	250	37	renal	renal	ADJ
gs-4062	250	38	and	and	CCONJ
gs-4062	250	39	bone	bone	NOUN
gs-4062	250	40	toxicity	toxicity	NOUN
gs-4062	250	41	.	.	PUNCT
gs-4062	251	1	serum	serum	NOUN
gs-4062	251	2	creatinine	creatinine	NOUN
gs-4062	251	3	elevations	elevation	NOUN
gs-4062	251	4	,	,	PUNCT
gs-4062	251	5	declines	decline	VERB
gs-4062	251	6	in	in	ADP
gs-4062	251	7	estimated	estimate	VERB
gs-4062	251	8	glomerular	glomerular	ADJ
gs-4062	251	9	filtration	filtration	NOUN
gs-4062	251	10	rate	rate	NOUN
gs-4062	251	11	,	,	PUNCT
gs-4062	251	12	and	and	CCONJ
gs-4062	251	13	instances	instance	NOUN
gs-4062	251	14	of	of	ADP
gs-4062	251	15	fanconi	fanconi	PROPN
gs-4062	251	16	syndrome	syndrome	PROPN
gs-4062	251	17	are	be	AUX
gs-4062	251	18	significantly	significantly	ADV
gs-4062	251	19	less	less	ADV
gs-4062	251	20	frequent	frequent	ADJ
gs-4062	251	21	with	with	ADP
gs-4062	251	22	taf	taf	PROPN
gs-4062	251	23	.	.	PUNCT
gs-4062	252	1	furthermore	furthermore	ADV
gs-4062	252	2	,	,	PUNCT
gs-4062	252	3	dual	dual	ADJ
gs-4062	252	4	-	-	PUNCT
gs-4062	252	5	energy	energy	NOUN
gs-4062	252	6	x	x	NOUN
gs-4062	252	7	-	-	NOUN
gs-4062	252	8	ray	ray	NOUN
gs-4062	252	9	absorptiometry	absorptiometry	NOUN
gs-4062	252	10	scans	scan	NOUN
gs-4062	252	11	reveal	reveal	VERB
gs-4062	252	12	significantly	significantly	ADV
gs-4062	252	13	less	less	ADJ
gs-4062	252	14	loss	loss	NOUN
gs-4062	252	15	of	of	ADP
gs-4062	252	16	bone	bone	NOUN
gs-4062	252	17	mineral	mineral	NOUN
gs-4062	252	18	density	density	NOUN
gs-4062	252	19	at	at	ADP
gs-4062	252	20	the	the	DET
gs-4062	252	21	hip	hip	NOUN
gs-4062	252	22	and	and	CCONJ
gs-4062	252	23	spine	spine	VERB
gs-4062	252	24	in	in	ADP
gs-4062	252	25	patients	patient	NOUN
gs-4062	252	26	initiating	initiate	VERB
gs-4062	252	27	taf	taf	X
gs-4062	252	28	compared	compare	VERB
gs-4062	252	29	to	to	ADP
gs-4062	252	30	those	those	PRON
gs-4062	252	31	on	on	ADP
gs-4062	252	32	tdf	tdf	PROPN
gs-4062	252	33	.	.	PUNCT
gs-4062	253	1	these	these	DET
gs-4062	253	2	results	result	NOUN
gs-4062	253	3	translate	translate	VERB
gs-4062	253	4	to	to	ADP
gs-4062	253	5	a	a	DET
gs-4062	253	6	tangible	tangible	ADJ
gs-4062	253	7	reduction	reduction	NOUN
gs-4062	253	8	in	in	ADP
gs-4062	253	9	long	long	ADJ
gs-4062	253	10	-	-	PUNCT
gs-4062	253	11	term	term	NOUN
gs-4062	253	12	morbidity	morbidity	NOUN
gs-4062	253	13	,	,	PUNCT
gs-4062	253	14	allowing	allow	VERB
gs-4062	253	15	clinicians	clinician	NOUN
gs-4062	253	16	to	to	PART
gs-4062	253	17	prescribe	prescribe	VERB
gs-4062	253	18	potent	potent	ADJ
gs-4062	253	19	nrti	nrti	NOUN
gs-4062	253	20	backbones	backbone	NOUN
gs-4062	253	21	without	without	ADP
gs-4062	253	22	the	the	DET
gs-4062	253	23	attendant	attendant	ADJ
gs-4062	253	24	concerns	concern	NOUN
gs-4062	253	25	for	for	ADP
gs-4062	253	26	cumulative	cumulative	ADJ
gs-4062	253	27	off	off	ADP
gs-4062	253	28	-	-	PUNCT
gs-4062	253	29	target	target	NOUN
gs-4062	253	30	organ	organ	NOUN
gs-4062	253	31	damage	damage	NOUN
gs-4062	253	32	,	,	PUNCT
gs-4062	253	33	a	a	DET
gs-4062	253	34	critical	critical	ADJ
gs-4062	253	35	consideration	consideration	NOUN
gs-4062	253	36	for	for	ADP
gs-4062	253	37	an	an	DET
gs-4062	253	38	aging	age	VERB
gs-4062	253	39	population	population	NOUN
gs-4062	253	40	of	of	ADP
gs-4062	253	41	people	people	NOUN
gs-4062	253	42	living	live	VERB
gs-4062	253	43	with	with	ADP
gs-4062	253	44	hiv	hiv	PROPN
gs-4062	253	45	who	who	PRON
gs-4062	253	46	require	require	VERB
gs-4062	253	47	lifelong	lifelong	ADJ
gs-4062	253	48	therapy	therapy	NOUN
gs-4062	253	49	.	.	PUNCT
gs-4062	254	1	beyond	beyond	ADP
gs-4062	254	2	refining	refine	VERB
gs-4062	254	3	existing	exist	VERB
gs-4062	254	4	classes	class	NOUN
gs-4062	254	5	,	,	PUNCT
gs-4062	254	6	the	the	DET
gs-4062	254	7	most	most	ADV
gs-4062	254	8	groundbreaking	groundbreaking	ADJ
gs-4062	254	9	results	result	NOUN
gs-4062	254	10	come	come	VERB
gs-4062	254	11	from	from	ADP
gs-4062	254	12	the	the	DET
gs-4062	254	13	development	development	NOUN
gs-4062	254	14	of	of	ADP
gs-4062	254	15	agents	agent	NOUN
gs-4062	254	16	with	with	ADP
gs-4062	254	17	entirely	entirely	ADV
gs-4062	254	18	novel	novel	ADJ
gs-4062	254	19	mechanisms	mechanism	NOUN
gs-4062	254	20	of	of	ADP
gs-4062	254	21	action	action	NOUN
gs-4062	254	22	.	.	PUNCT
gs-4062	255	1	the	the	DET
gs-4062	255	2	capsid	capsid	ADJ
gs-4062	255	3	inhibitor	inhibitor	NOUN
gs-4062	255	4	lenacapavir	lenacapavir	NOUN
gs-4062	255	5	represents	represent	VERB
gs-4062	255	6	one	one	NUM
gs-4062	255	7	such	such	ADJ
gs-4062	255	8	leap	leap	NOUN
gs-4062	255	9	forward	forward	ADV
gs-4062	255	10	.	.	PUNCT
gs-4062	256	1	clinical	clinical	ADJ
gs-4062	256	2	trial	trial	NOUN
gs-4062	256	3	results	result	NOUN
gs-4062	256	4	in	in	ADP
gs-4062	256	5	heavily	heavily	ADV
gs-4062	256	6	treatment	treatment	NOUN
gs-4062	256	7	-	-	PUNCT
gs-4062	256	8	experienced	experience	VERB
gs-4062	256	9	patients	patient	NOUN
gs-4062	256	10	with	with	ADP
gs-4062	256	11	multidrug	multidrug	NOUN
gs-4062	256	12	-	-	PUNCT
gs-4062	256	13	resistant	resistant	ADJ
gs-4062	256	14	virus	virus	NOUN
gs-4062	256	15	have	have	AUX
gs-4062	256	16	been	be	AUX
gs-4062	256	17	nothing	nothing	PRON
gs-4062	256	18	short	short	ADJ
gs-4062	256	19	of	of	ADP
gs-4062	256	20	spectacular	spectacular	ADJ
gs-4062	256	21	.	.	PUNCT
gs-4062	257	1	in	in	ADP
gs-4062	257	2	a	a	DET
gs-4062	257	3	population	population	NOUN
gs-4062	257	4	for	for	ADP
gs-4062	257	5	whom	whom	PRON
gs-4062	257	6	effective	effective	ADJ
gs-4062	257	7	therapeutic	therapeutic	ADJ
gs-4062	257	8	options	option	NOUN
gs-4062	257	9	were	be	AUX
gs-4062	257	10	nearly	nearly	ADV
gs-4062	257	11	exhausted	exhausted	ADJ
gs-4062	257	12	,	,	PUNCT
gs-4062	257	13	subcutaneous	subcutaneous	ADJ
gs-4062	257	14	administration	administration	NOUN
gs-4062	257	15	of	of	ADP
gs-4062	257	16	lenacapavir	lenacapavir	PROPN
gs-4062	257	17	as	as	ADP
gs-4062	257	18	part	part	NOUN
gs-4062	257	19	of	of	ADP
gs-4062	257	20	an	an	DET
gs-4062	257	21	optimized	optimize	VERB
gs-4062	257	22	background	background	NOUN
gs-4062	257	23	regimen	regiman	NOUN
gs-4062	257	24	resulted	result	VERB
gs-4062	257	25	in	in	ADP
gs-4062	257	26	a	a	DET
gs-4062	257	27	significant	significant	ADJ
gs-4062	257	28	majority	majority	NOUN
gs-4062	257	29	of	of	ADP
gs-4062	257	30	participants	participant	NOUN
gs-4062	257	31	achieving	achieve	VERB
gs-4062	257	32	virological	virological	ADJ
gs-4062	257	33	suppression	suppression	NOUN
gs-4062	257	34	to	to	ADP
gs-4062	257	35	undetectable	undetectable	ADJ
gs-4062	257	36	levels	level	NOUN
gs-4062	257	37	.	.	PUNCT
gs-4062	258	1	the	the	DET
gs-4062	258	2	mechanistic	mechanistic	ADJ
gs-4062	258	3	results	result	NOUN
gs-4062	258	4	elucidate	elucidate	VERB
gs-4062	258	5	why	why	SCONJ
gs-4062	258	6	this	this	PRON
gs-4062	258	7	is	be	AUX
gs-4062	258	8	possible	possible	ADJ
gs-4062	258	9	;	;	PUNCT
gs-4062	258	10	lenacapavir	lenacapavir	NOUN
gs-4062	258	11	targets	target	VERB
gs-4062	258	12	the	the	DET
gs-4062	258	13	viral	viral	ADJ
gs-4062	258	14	capsid	capsid	NOUN
gs-4062	258	15	,	,	PUNCT
gs-4062	258	16	a	a	DET
gs-4062	258	17	structure	structure	NOUN
gs-4062	258	18	previously	previously	ADV
gs-4062	258	19	unexploited	unexploite	VERB
gs-4062	258	20	therapeutically	therapeutically	ADV
gs-4062	258	21	,	,	PUNCT
gs-4062	258	22	and	and	CCONJ
gs-4062	258	23	disrupts	disrupt	VERB
gs-4062	258	24	its	its	PRON
gs-4062	258	25	function	function	NOUN
gs-4062	258	26	at	at	ADP
gs-4062	258	27	multiple	multiple	ADJ
gs-4062	258	28	points	point	NOUN
gs-4062	258	29	in	in	ADP
gs-4062	258	30	the	the	DET
gs-4062	258	31	life	life	NOUN
gs-4062	258	32	cycle	cycle	NOUN
gs-4062	258	33	—	—	PUNCT
gs-4062	258	34	including	include	VERB
gs-4062	258	35	nuclear	nuclear	ADJ
gs-4062	258	36	import	import	NOUN
gs-4062	258	37	of	of	ADP
gs-4062	258	38	the	the	DET
gs-4062	258	39	viral	viral	ADJ
gs-4062	258	40	genome	genome	NOUN
gs-4062	258	41	and	and	CCONJ
gs-4062	258	42	the	the	DET
gs-4062	258	43	assembly	assembly	NOUN
gs-4062	258	44	of	of	ADP
gs-4062	258	45	new	new	ADJ
gs-4062	258	46	virions	virion	NOUN
gs-4062	258	47	.	.	PUNCT
gs-4062	259	1	this	this	DET
gs-4062	259	2	multi	multi	ADJ
gs-4062	259	3	-	-	ADJ
gs-4062	259	4	stage	stage	ADJ
gs-4062	259	5	inhibition	inhibition	NOUN
gs-4062	259	6	creates	create	VERB
gs-4062	259	7	a	a	DET
gs-4062	259	8	exceptionally	exceptionally	ADV
gs-4062	259	9	high	high	ADJ
gs-4062	259	10	barrier	barrier	NOUN
gs-4062	259	11	to	to	ADP
gs-4062	259	12	resistance	resistance	NOUN
gs-4062	259	13	.	.	PUNCT
gs-4062	260	1	furthermore	furthermore	ADV
gs-4062	260	2	,	,	PUNCT
gs-4062	260	3	its	its	PRON
gs-4062	260	4	extraordinary	extraordinary	ADJ
gs-4062	260	5	pharmacokinetic	pharmacokinetic	ADJ
gs-4062	260	6	profile	profile	NOUN
gs-4062	260	7	,	,	PUNCT
gs-4062	260	8	with	with	ADP
gs-4062	260	9	a	a	DET
gs-4062	260	10	half	half	ADJ
gs-4062	260	11	-	-	PUNCT
gs-4062	260	12	life	life	NOUN
gs-4062	260	13	extending	extend	VERB
gs-4062	260	14	to	to	ADP
gs-4062	260	15	several	several	ADJ
gs-4062	260	16	months	month	NOUN
gs-4062	260	17	,	,	PUNCT
gs-4062	260	18	is	be	AUX
gs-4062	260	19	a	a	DET
gs-4062	260	20	result	result	NOUN
gs-4062	260	21	that	that	PRON
gs-4062	260	22	opens	open	VERB
gs-4062	260	23	the	the	DET
gs-4062	260	24	door	door	NOUN
gs-4062	260	25	to	to	ADP
gs-4062	260	26	ultra	ultra	ADJ
gs-4062	260	27	-	-	ADJ
gs-4062	260	28	long	long	ADV
gs-4062	260	29	-	-	PUNCT
gs-4062	260	30	acting	act	VERB
gs-4062	260	31	administration	administration	NOUN
gs-4062	260	32	schedules	schedule	NOUN
gs-4062	260	33	,	,	PUNCT
gs-4062	260	34	potentially	potentially	ADV
gs-4062	260	35	reducing	reduce	VERB
gs-4062	260	36	treatment	treatment	NOUN
gs-4062	260	37	from	from	ADP
gs-4062	260	38	365	365	NUM
gs-4062	260	39	daily	daily	ADJ
gs-4062	260	40	doses	dose	NOUN
gs-4062	260	41	to	to	ADP
gs-4062	260	42	a	a	DET
gs-4062	260	43	mere	mere	ADJ
gs-4062	260	44	handful	handful	NOUN
gs-4062	260	45	of	of	ADP
gs-4062	260	46	injections	injection	NOUN
gs-4062	260	47	per	per	ADP
gs-4062	260	48	year	year	NOUN
gs-4062	260	49	.	.	PUNCT
gs-4062	261	1	the	the	DET
gs-4062	261	2	successful	successful	ADJ
gs-4062	261	3	development	development	NOUN
gs-4062	261	4	of	of	ADP
gs-4062	261	5	long	long	ADV
gs-4062	261	6	-	-	PUNCT
gs-4062	261	7	acting	act	VERB
gs-4062	261	8	injectable	injectable	ADJ
gs-4062	261	9	antiretroviral	antiretroviral	ADJ
gs-4062	261	10	therapy	therapy	NOUN
gs-4062	261	11	is	be	AUX
gs-4062	261	12	perhaps	perhaps	ADV
gs-4062	261	13	the	the	DET
gs-4062	261	14	most	most	ADV
gs-4062	261	15	patient	patient	ADJ
gs-4062	261	16	-	-	PUNCT
gs-4062	261	17	centric	centric	ADJ
gs-4062	261	18	result	result	NOUN
gs-4062	261	19	of	of	ADP
gs-4062	261	20	the	the	DET
gs-4062	261	21	modern	modern	ADJ
gs-4062	261	22	era	era	NOUN
gs-4062	261	23	.	.	PUNCT
gs-4062	262	1	the	the	DET
gs-4062	262	2	pivotal	pivotal	ADJ
gs-4062	262	3	trials	trial	NOUN
gs-4062	262	4	for	for	ADP
gs-4062	262	5	the	the	DET
gs-4062	262	6	intramuscular	intramuscular	ADJ
gs-4062	262	7	combination	combination	NOUN
gs-4062	262	8	of	of	ADP
gs-4062	262	9	cabotegravir	cabotegravir	PRON
gs-4062	262	10	and	and	CCONJ
gs-4062	262	11	rilpivirine	rilpivirine	NOUN
gs-4062	262	12	demonstrated	demonstrate	VERB
gs-4062	262	13	that	that	SCONJ
gs-4062	262	14	maintenance	maintenance	NOUN
gs-4062	262	15	of	of	ADP
gs-4062	262	16	virological	virological	ADJ
gs-4062	262	17	suppression	suppression	NOUN
gs-4062	262	18	was	be	AUX
gs-4062	262	19	noninferior	noninferior	ADJ
gs-4062	262	20	to	to	ADP
gs-4062	262	21	continuation	continuation	NOUN
gs-4062	262	22	of	of	ADP
gs-4062	262	23	daily	daily	ADJ
gs-4062	262	24	oral	oral	ADJ
gs-4062	262	25	three	three	NUM
gs-4062	262	26	-	-	PUNCT
gs-4062	262	27	drug	drug	NOUN
gs-4062	262	28	therapy	therapy	NOUN
gs-4062	262	29	.	.	PUNCT
gs-4062	263	1	this	this	DET
gs-4062	263	2	result	result	NOUN
gs-4062	263	3	validates	validate	VERB
gs-4062	263	4	a	a	DET
gs-4062	263	5	fundamental	fundamental	ADJ
gs-4062	263	6	shift	shift	NOUN
gs-4062	263	7	in	in	ADP
gs-4062	263	8	the	the	DET
gs-4062	263	9	philosophy	philosophy	NOUN
gs-4062	263	10	of	of	ADP
gs-4062	263	11	hiv	hiv	PROPN
gs-4062	263	12	care	care	NOUN
gs-4062	263	13	—	—	PUNCT
gs-4062	263	14	from	from	ADP
gs-4062	263	15	a	a	DET
gs-4062	263	16	daily	daily	ADJ
gs-4062	263	17	reminder	reminder	NOUN
gs-4062	263	18	of	of	ADP
gs-4062	263	19	a	a	DET
gs-4062	263	20	chronic	chronic	ADJ
gs-4062	263	21	condition	condition	NOUN
gs-4062	263	22	to	to	ADP
gs-4062	263	23	a	a	DET
gs-4062	263	24	discreet	discreet	ADJ
gs-4062	263	25	,	,	PUNCT
gs-4062	263	26	infrequent	infrequent	ADJ
gs-4062	263	27	intervention	intervention	NOUN
gs-4062	263	28	.	.	PUNCT
gs-4062	264	1	the	the	DET
gs-4062	264	2	discussion	discussion	NOUN
gs-4062	264	3	around	around	ADP
gs-4062	264	4	these	these	DET
gs-4062	264	5	results	result	NOUN
gs-4062	264	6	must	must	AUX
gs-4062	264	7	acknowledge	acknowledge	VERB
gs-4062	264	8	the	the	DET
gs-4062	264	9	importance	importance	NOUN
gs-4062	264	10	of	of	ADP
gs-4062	264	11	adherence	adherence	NOUN
gs-4062	264	12	in	in	ADP
gs-4062	264	13	a	a	DET
gs-4062	264	14	new	new	ADJ
gs-4062	264	15	form	form	NOUN
gs-4062	264	16	;	;	PUNCT
gs-4062	264	17	while	while	SCONJ
gs-4062	264	18	freeing	free	VERB
gs-4062	264	19	patients	patient	NOUN
gs-4062	264	20	from	from	ADP
gs-4062	264	21	daily	daily	ADJ
gs-4062	264	22	pills	pill	NOUN
gs-4062	264	23	,	,	PUNCT
gs-4062	264	24	it	it	PRON
gs-4062	264	25	introduces	introduce	VERB
gs-4062	264	26	the	the	DET
gs-4062	264	27	necessity	necessity	NOUN
gs-4062	264	28	of	of	ADP
gs-4062	264	29	strict	strict	ADJ
gs-4062	264	30	adherence	adherence	NOUN
gs-4062	264	31	to	to	ADP
gs-4062	264	32	injection	injection	NOUN
gs-4062	264	33	appointments	appointment	NOUN
gs-4062	264	34	.	.	PUNCT
gs-4062	265	1	nevertheless	nevertheless	ADV
gs-4062	265	2	,	,	PUNCT
gs-4062	265	3	patient	patient	NOUN
gs-4062	265	4	-	-	PUNCT
gs-4062	265	5	reported	report	VERB
gs-4062	265	6	outcomes	outcome	NOUN
gs-4062	265	7	from	from	ADP
gs-4062	265	8	these	these	DET
gs-4062	265	9	studies	study	NOUN
gs-4062	265	10	consistently	consistently	ADV
gs-4062	265	11	show	show	VERB
gs-4062	265	12	a	a	DET
gs-4062	265	13	strong	strong	ADJ
gs-4062	265	14	preference	preference	NOUN
gs-4062	265	15	for	for	ADP
gs-4062	265	16	the	the	DET
gs-4062	265	17	injectable	injectable	ADJ
gs-4062	265	18	modality	modality	NOUN
gs-4062	265	19	,	,	PUNCT
gs-4062	265	20	citing	cite	VERB
gs-4062	265	21	benefits	benefit	NOUN
gs-4062	265	22	for	for	ADP
gs-4062	265	23	mental	mental	ADJ
gs-4062	265	24	health	health	NOUN
gs-4062	265	25	,	,	PUNCT
gs-4062	265	26	stigma	stigma	NOUN
gs-4062	265	27	reduction	reduction	NOUN
gs-4062	265	28	,	,	PUNCT
gs-4062	265	29	and	and	CCONJ
gs-4062	265	30	overall	overall	ADJ
gs-4062	265	31	quality	quality	NOUN
gs-4062	265	32	of	of	ADP
gs-4062	265	33	life	life	NOUN
gs-4062	265	34	.	.	PUNCT
gs-4062	266	1	this	this	PRON
gs-4062	266	2	represents	represent	VERB
gs-4062	266	3	a	a	DET
gs-4062	266	4	crucial	crucial	ADJ
gs-4062	266	5	result	result	NOUN
gs-4062	266	6	:	:	PUNCT
gs-4062	266	7	that	that	SCONJ
gs-4062	266	8	therapeutic	therapeutic	ADJ
gs-4062	266	9	success	success	NOUN
gs-4062	266	10	is	be	AUX
gs-4062	266	11	no	no	ADV
gs-4062	266	12	longer	long	ADV
gs-4062	266	13	measured	measure	VERB
gs-4062	266	14	solely	solely	ADV
gs-4062	266	15	by	by	ADP
gs-4062	266	16	virological	virological	ADJ
gs-4062	266	17	endpoints	endpoint	NOUN
gs-4062	266	18	but	but	CCONJ
gs-4062	266	19	also	also	ADV
gs-4062	266	20	by	by	ADP
gs-4062	266	21	its	its	PRON
gs-4062	266	22	integration	integration	NOUN
gs-4062	266	23	into	into	ADP
gs-4062	266	24	and	and	CCONJ
gs-4062	266	25	positive	positive	ADJ
gs-4062	266	26	impact	impact	NOUN
gs-4062	266	27	on	on	ADP
gs-4062	266	28	a	a	DET
gs-4062	266	29	patient	patient	NOUN
gs-4062	266	30	's	's	PART
gs-4062	266	31	life	life	NOUN
gs-4062	266	32	.	.	PUNCT
gs-4062	267	1	however	however	ADV
gs-4062	267	2	,	,	PUNCT
gs-4062	267	3	this	this	DET
gs-4062	267	4	comprehensive	comprehensive	ADJ
gs-4062	267	5	analysis	analysis	NOUN
gs-4062	267	6	would	would	AUX
gs-4062	267	7	be	be	AUX
gs-4062	267	8	incomplete	incomplete	ADJ
gs-4062	267	9	without	without	ADP
gs-4062	267	10	a	a	DET
gs-4062	267	11	thorough	thorough	ADJ
gs-4062	267	12	discussion	discussion	NOUN
gs-4062	267	13	of	of	ADP
gs-4062	267	14	the	the	DET
gs-4062	267	15	emerging	emerge	VERB
gs-4062	267	16	and	and	CCONJ
gs-4062	267	17	sometimes	sometimes	ADV
gs-4062	267	18	unexpected	unexpected	ADJ
gs-4062	267	19	safety	safety	NOUN
gs-4062	267	20	signals	signal	NOUN
gs-4062	267	21	associated	associate	VERB
gs-4062	267	22	with	with	ADP
gs-4062	267	23	these	these	DET
gs-4062	267	24	new	new	ADJ
gs-4062	267	25	agents	agent	NOUN
gs-4062	267	26	.	.	PUNCT
gs-4062	268	1	the	the	DET
gs-4062	268	2	most	most	ADV
gs-4062	268	3	widely	widely	ADV
gs-4062	268	4	discussed	discuss	VERB
gs-4062	268	5	and	and	CCONJ
gs-4062	268	6	carefully	carefully	ADV
gs-4062	268	7	monitored	monitor	VERB
gs-4062	268	8	result	result	NOUN
gs-4062	268	9	pertains	pertain	NOUN
gs-4062	268	10	to	to	ADP
gs-4062	268	11	the	the	DET
gs-4062	268	12	issue	issue	NOUN
gs-4062	268	13	of	of	ADP
gs-4062	268	14	weight	weight	NOUN
gs-4062	268	15	gain	gain	NOUN
gs-4062	268	16	associated	associate	VERB
gs-4062	268	17	with	with	ADP
gs-4062	268	18	insti	insti	NOUN
gs-4062	268	19	-	-	PUNCT
gs-4062	268	20	based	base	VERB
gs-4062	268	21	regimens	regimen	NOUN
gs-4062	268	22	.	.	PUNCT
gs-4062	269	1	pooled	pool	VERB
gs-4062	269	2	data	datum	NOUN
gs-4062	269	3	from	from	ADP
gs-4062	269	4	numerous	numerous	ADJ
gs-4062	269	5	clinical	clinical	ADJ
gs-4062	269	6	trials	trial	NOUN
gs-4062	269	7	and	and	CCONJ
gs-4062	269	8	observational	observational	ADJ
gs-4062	269	9	cohorts	cohort	NOUN
gs-4062	269	10	have	have	AUX
gs-4062	269	11	consistently	consistently	ADV
gs-4062	269	12	shown	show	VERB
gs-4062	269	13	that	that	SCONJ
gs-4062	269	14	patients	patient	NOUN
gs-4062	269	15	initiating	initiate	VERB
gs-4062	269	16	therapy	therapy	NOUN
gs-4062	269	17	with	with	ADP
gs-4062	269	18	dolutegravir	dolutegravir	NOUN
gs-4062	269	19	or	or	CCONJ
gs-4062	269	20	bictegravir	bictegravir	PROPN
gs-4062	269	21	experience	experience	VERB
gs-4062	269	22	a	a	DET
gs-4062	269	23	greater	great	ADJ
gs-4062	269	24	increase	increase	NOUN
gs-4062	269	25	in	in	ADP
gs-4062	269	26	body	body	NOUN
gs-4062	269	27	mass	mass	NOUN
gs-4062	269	28	index	index	NOUN
gs-4062	269	29	over	over	ADP
gs-4062	269	30	time	time	NOUN
gs-4062	269	31	compared	compare	VERB
gs-4062	269	32	to	to	ADP
gs-4062	269	33	those	those	PRON
gs-4062	269	34	on	on	ADP
gs-4062	269	35	regimens	regimen	NOUN
gs-4062	269	36	based	base	VERB
gs-4062	269	37	on	on	ADP
gs-4062	269	38	older	old	ADJ
gs-4062	269	39	agents	agent	NOUN
gs-4062	269	40	like	like	ADP
gs-4062	269	41	efavirenz	efavirenz	NOUN
gs-4062	269	42	,	,	PUNCT
gs-4062	269	43	darunavir	darunavir	PROPN
gs-4062	269	44	,	,	PUNCT
gs-4062	269	45	or	or	CCONJ
gs-4062	269	46	even	even	ADV
gs-4062	269	47	raltegravir	raltegravir	PROPN
gs-4062	269	48	.	.	PUNCT
gs-4062	270	1	this	this	DET
gs-4062	270	2	effect	effect	NOUN
gs-4062	270	3	is	be	AUX
gs-4062	270	4	most	most	ADV
gs-4062	270	5	pronounced	pronounce	VERB
gs-4062	270	6	in	in	ADP
gs-4062	270	7	certain	certain	ADJ
gs-4062	270	8	demographic	demographic	ADJ
gs-4062	270	9	groups	group	NOUN
gs-4062	270	10	,	,	PUNCT
gs-4062	270	11	specifically	specifically	ADV
gs-4062	270	12	women	woman	NOUN
gs-4062	270	13	of	of	ADP
gs-4062	270	14	african	african	ADJ
gs-4062	270	15	descent	descent	NOUN
gs-4062	270	16	.	.	PUNCT
gs-4062	271	1	the	the	DET
gs-4062	271	2	mechanistic	mechanistic	ADJ
gs-4062	271	3	underpinnings	underpinning	NOUN
gs-4062	271	4	of	of	ADP
gs-4062	271	5	this	this	DET
gs-4062	271	6	georgian	georgian	NOUN
gs-4062	271	7	scientists/	scientists/	NUM
gs-4062	271	8	.	.	PUNCT
gs-4062	272	1	7	7	NUM
gs-4062	272	2	n	n	PRON
gs-4062	272	3	3	3	NUM
gs-4062	272	4	,	,	PUNCT
gs-4062	272	5	2025	2025	NUM
gs-4062	272	6	534	534	NUM
gs-4062	272	7	result	result	NOUN
gs-4062	272	8	remain	remain	VERB
gs-4062	272	9	a	a	DET
gs-4062	272	10	subject	subject	NOUN
gs-4062	272	11	of	of	ADP
gs-4062	272	12	intense	intense	ADJ
gs-4062	272	13	investigation	investigation	NOUN
gs-4062	272	14	.	.	PUNCT
gs-4062	273	1	hypotheses	hypothesis	NOUN
gs-4062	273	2	include	include	VERB
gs-4062	273	3	off	off	ADP
gs-4062	273	4	-	-	PUNCT
gs-4062	273	5	target	target	NOUN
gs-4062	273	6	effects	effect	NOUN
gs-4062	273	7	on	on	ADP
gs-4062	273	8	melanocortin-4	melanocortin-4	NUM
gs-4062	273	9	receptors	receptor	NOUN
gs-4062	273	10	involved	involve	VERB
gs-4062	273	11	in	in	ADP
gs-4062	273	12	appetite	appetite	ADJ
gs-4062	273	13	regulation	regulation	NOUN
gs-4062	273	14	,	,	PUNCT
gs-4062	273	15	interactions	interaction	NOUN
gs-4062	273	16	with	with	ADP
gs-4062	273	17	adipose	adipose	PRON
gs-4062	273	18	tissue	tissue	NOUN
gs-4062	273	19	metabolism	metabolism	NOUN
gs-4062	273	20	,	,	PUNCT
gs-4062	273	21	or	or	CCONJ
gs-4062	273	22	perhaps	perhaps	ADV
gs-4062	273	23	a	a	DET
gs-4062	273	24	more	more	ADV
gs-4062	273	25	indirect	indirect	ADJ
gs-4062	273	26	effect	effect	NOUN
gs-4062	273	27	related	relate	VERB
gs-4062	273	28	to	to	ADP
gs-4062	273	29	superior	superior	ADJ
gs-4062	273	30	metabolic	metabolic	NOUN
gs-4062	273	31	health	health	NOUN
gs-4062	273	32	and	and	CCONJ
gs-4062	273	33	well	well	ADV
gs-4062	273	34	-	-	PUNCT
gs-4062	273	35	being	be	AUX
gs-4062	273	36	leading	lead	VERB
gs-4062	273	37	to	to	ADP
gs-4062	273	38	increased	increase	VERB
gs-4062	273	39	appetite	appetite	NOUN
gs-4062	273	40	.	.	PUNCT
gs-4062	274	1	while	while	SCONJ
gs-4062	274	2	the	the	DET
gs-4062	274	3	clinical	clinical	ADJ
gs-4062	274	4	significance	significance	NOUN
gs-4062	274	5	of	of	ADP
gs-4062	274	6	this	this	DET
gs-4062	274	7	weight	weight	NOUN
gs-4062	274	8	gain	gain	NOUN
gs-4062	274	9	is	be	AUX
gs-4062	274	10	still	still	ADV
gs-4062	274	11	being	be	AUX
gs-4062	274	12	evaluated	evaluate	VERB
gs-4062	274	13	,	,	PUNCT
gs-4062	274	14	with	with	ADP
gs-4062	274	15	some	some	DET
gs-4062	274	16	patients	patient	NOUN
gs-4062	274	17	crossing	cross	VERB
gs-4062	274	18	into	into	ADP
gs-4062	274	19	obesity	obesity	NOUN
gs-4062	274	20	and	and	CCONJ
gs-4062	274	21	associated	associated	ADJ
gs-4062	274	22	health	health	NOUN
gs-4062	274	23	risks	risk	NOUN
gs-4062	274	24	,	,	PUNCT
gs-4062	274	25	it	it	PRON
gs-4062	274	26	is	be	AUX
gs-4062	274	27	a	a	DET
gs-4062	274	28	critical	critical	ADJ
gs-4062	274	29	result	result	NOUN
gs-4062	274	30	that	that	PRON
gs-4062	274	31	necessitates	necessitate	VERB
gs-4062	274	32	ongoing	ongoing	ADJ
gs-4062	274	33	surveillance	surveillance	NOUN
gs-4062	274	34	,	,	PUNCT
gs-4062	274	35	patient	patient	ADJ
gs-4062	274	36	counseling	counseling	NOUN
gs-4062	274	37	,	,	PUNCT
gs-4062	274	38	and	and	CCONJ
gs-4062	274	39	research	research	NOUN
gs-4062	274	40	into	into	ADP
gs-4062	274	41	mitigating	mitigate	VERB
gs-4062	274	42	strategies	strategy	NOUN
gs-4062	274	43	.	.	PUNCT
gs-4062	275	1	another	another	DET
gs-4062	275	2	area	area	NOUN
gs-4062	275	3	of	of	ADP
gs-4062	275	4	discussion	discussion	NOUN
gs-4062	275	5	centers	center	NOUN
gs-4062	275	6	on	on	ADP
gs-4062	275	7	the	the	DET
gs-4062	275	8	neuropsychiatric	neuropsychiatric	ADJ
gs-4062	275	9	profile	profile	NOUN
gs-4062	275	10	of	of	ADP
gs-4062	275	11	certain	certain	ADJ
gs-4062	275	12	newer	new	ADJ
gs-4062	275	13	agents	agent	NOUN
gs-4062	275	14	.	.	PUNCT
gs-4062	276	1	early	early	ADJ
gs-4062	276	2	results	result	NOUN
gs-4062	276	3	from	from	ADP
gs-4062	276	4	dolutegravir	dolutegravir	PROPN
gs-4062	276	5	clinical	clinical	ADJ
gs-4062	276	6	trials	trial	NOUN
gs-4062	276	7	indicated	indicate	VERB
gs-4062	276	8	a	a	DET
gs-4062	276	9	higher	high	ADJ
gs-4062	276	10	incidence	incidence	NOUN
gs-4062	276	11	of	of	ADP
gs-4062	276	12	insomnia	insomnia	NOUN
gs-4062	276	13	,	,	PUNCT
gs-4062	276	14	anxiety	anxiety	NOUN
gs-4062	276	15	,	,	PUNCT
gs-4062	276	16	and	and	CCONJ
gs-4062	276	17	in	in	ADP
gs-4062	276	18	rare	rare	ADJ
gs-4062	276	19	cases	case	NOUN
gs-4062	276	20	,	,	PUNCT
gs-4062	276	21	suicidal	suicidal	ADJ
gs-4062	276	22	ideation	ideation	NOUN
gs-4062	276	23	,	,	PUNCT
gs-4062	276	24	particularly	particularly	ADV
gs-4062	276	25	in	in	ADP
gs-4062	276	26	the	the	DET
gs-4062	276	27	first	first	ADJ
gs-4062	276	28	few	few	ADJ
gs-4062	276	29	weeks	week	NOUN
gs-4062	276	30	of	of	ADP
gs-4062	276	31	therapy	therapy	NOUN
gs-4062	276	32	.	.	PUNCT
gs-4062	277	1	this	this	PRON
gs-4062	277	2	led	lead	VERB
gs-4062	277	3	to	to	ADP
gs-4062	277	4	initial	initial	ADJ
gs-4062	277	5	caution	caution	NOUN
gs-4062	277	6	and	and	CCONJ
gs-4062	277	7	specific	specific	ADJ
gs-4062	277	8	guidance	guidance	NOUN
gs-4062	277	9	against	against	ADP
gs-4062	277	10	use	use	NOUN
gs-4062	277	11	in	in	ADP
gs-4062	277	12	patients	patient	NOUN
gs-4062	277	13	with	with	ADP
gs-4062	277	14	pre	pre	ADJ
gs-4062	277	15	-	-	ADJ
gs-4062	277	16	existing	existing	ADJ
gs-4062	277	17	psychiatric	psychiatric	ADJ
gs-4062	277	18	conditions	condition	NOUN
gs-4062	277	19	.	.	PUNCT
gs-4062	278	1	however	however	ADV
gs-4062	278	2	,	,	PUNCT
gs-4062	278	3	longer	long	ADJ
gs-4062	278	4	-	-	PUNCT
gs-4062	278	5	term	term	NOUN
gs-4062	278	6	follow	follow	NOUN
gs-4062	278	7	-	-	PUNCT
gs-4062	278	8	up	up	NOUN
gs-4062	278	9	and	and	CCONJ
gs-4062	278	10	larger	large	ADJ
gs-4062	278	11	real	real	ADJ
gs-4062	278	12	-	-	PUNCT
gs-4062	278	13	world	world	NOUN
gs-4062	278	14	evidence	evidence	NOUN
gs-4062	278	15	studies	study	NOUN
gs-4062	278	16	have	have	AUX
gs-4062	278	17	provided	provide	VERB
gs-4062	278	18	a	a	DET
gs-4062	278	19	more	more	ADV
gs-4062	278	20	nuanced	nuanced	ADJ
gs-4062	278	21	result	result	NOUN
gs-4062	278	22	.	.	PUNCT
gs-4062	279	1	it	it	PRON
gs-4062	279	2	appears	appear	VERB
gs-4062	279	3	that	that	SCONJ
gs-4062	279	4	these	these	DET
gs-4062	279	5	adverse	adverse	ADJ
gs-4062	279	6	effects	effect	NOUN
gs-4062	279	7	are	be	AUX
gs-4062	279	8	often	often	ADV
gs-4062	279	9	transient	transient	ADJ
gs-4062	279	10	and	and	CCONJ
gs-4062	279	11	self	self	NOUN
gs-4062	279	12	-	-	PUNCT
gs-4062	279	13	limiting	limit	VERB
gs-4062	279	14	,	,	PUNCT
gs-4062	279	15	resolving	resolve	VERB
gs-4062	279	16	within	within	ADP
gs-4062	279	17	the	the	DET
gs-4062	279	18	first	first	ADJ
gs-4062	279	19	four	four	NUM
gs-4062	279	20	to	to	PART
gs-4062	279	21	eight	eight	NUM
gs-4062	279	22	weeks	week	NOUN
gs-4062	279	23	of	of	ADP
gs-4062	279	24	treatment	treatment	NOUN
gs-4062	279	25	for	for	ADP
gs-4062	279	26	the	the	DET
gs-4062	279	27	majority	majority	NOUN
gs-4062	279	28	of	of	ADP
gs-4062	279	29	patients	patient	NOUN
gs-4062	279	30	who	who	PRON
gs-4062	279	31	experience	experience	VERB
gs-4062	279	32	them	they	PRON
gs-4062	279	33	.	.	PUNCT
gs-4062	280	1	the	the	DET
gs-4062	280	2	discussion	discussion	NOUN
gs-4062	280	3	here	here	ADV
gs-4062	280	4	highlights	highlight	VERB
gs-4062	280	5	the	the	DET
gs-4062	280	6	importance	importance	NOUN
gs-4062	280	7	of	of	ADP
gs-4062	280	8	distinguishing	distinguish	VERB
gs-4062	280	9	between	between	ADP
gs-4062	280	10	short	short	ADJ
gs-4062	280	11	-	-	PUNCT
gs-4062	280	12	term	term	NOUN
gs-4062	280	13	tolerability	tolerability	NOUN
gs-4062	280	14	issues	issue	NOUN
gs-4062	280	15	and	and	CCONJ
gs-4062	280	16	long	long	ADJ
gs-4062	280	17	-	-	PUNCT
gs-4062	280	18	term	term	NOUN
gs-4062	280	19	safety	safety	NOUN
gs-4062	280	20	concerns	concern	NOUN
gs-4062	280	21	.	.	PUNCT
gs-4062	281	1	it	it	PRON
gs-4062	281	2	also	also	ADV
gs-4062	281	3	underscores	underscore	VERB
gs-4062	281	4	the	the	DET
gs-4062	281	5	critical	critical	ADJ
gs-4062	281	6	role	role	NOUN
gs-4062	281	7	of	of	ADP
gs-4062	281	8	the	the	DET
gs-4062	281	9	clinician	clinician	NOUN
gs-4062	281	10	in	in	ADP
gs-4062	281	11	pretherapy	pretherapy	NOUN
gs-4062	281	12	counseling	counseling	NOUN
gs-4062	281	13	,	,	PUNCT
gs-4062	281	14	managing	manage	VERB
gs-4062	281	15	patient	patient	ADJ
gs-4062	281	16	expectations	expectation	NOUN
gs-4062	281	17	,	,	PUNCT
gs-4062	281	18	and	and	CCONJ
gs-4062	281	19	providing	provide	VERB
gs-4062	281	20	supportive	supportive	ADJ
gs-4062	281	21	management	management	NOUN
gs-4062	281	22	during	during	ADP
gs-4062	281	23	the	the	DET
gs-4062	281	24	initiation	initiation	NOUN
gs-4062	281	25	phase	phase	NOUN
gs-4062	281	26	to	to	PART
gs-4062	281	27	ensure	ensure	VERB
gs-4062	281	28	persistence	persistence	NOUN
gs-4062	281	29	with	with	ADP
gs-4062	281	30	an	an	DET
gs-4062	281	31	otherwise	otherwise	ADV
gs-4062	281	32	supremely	supremely	ADV
gs-4062	281	33	effective	effective	ADJ
gs-4062	281	34	regimen	regiman	NOUN
gs-4062	281	35	.	.	PUNCT
gs-4062	282	1	the	the	DET
gs-4062	282	2	discussion	discussion	NOUN
gs-4062	282	3	of	of	ADP
gs-4062	282	4	results	result	NOUN
gs-4062	282	5	must	must	AUX
gs-4062	282	6	also	also	ADV
gs-4062	282	7	extend	extend	VERB
gs-4062	282	8	to	to	ADP
gs-4062	282	9	the	the	DET
gs-4062	282	10	practical	practical	ADJ
gs-4062	282	11	and	and	CCONJ
gs-4062	282	12	economic	economic	ADJ
gs-4062	282	13	implications	implication	NOUN
gs-4062	282	14	of	of	ADP
gs-4062	282	15	implementing	implement	VERB
gs-4062	282	16	these	these	DET
gs-4062	282	17	new	new	ADJ
gs-4062	282	18	therapies	therapy	NOUN
gs-4062	282	19	on	on	ADP
gs-4062	282	20	a	a	DET
gs-4062	282	21	global	global	ADJ
gs-4062	282	22	scale	scale	NOUN
gs-4062	282	23	.	.	PUNCT
gs-4062	283	1	the	the	DET
gs-4062	283	2	superior	superior	ADJ
gs-4062	283	3	efficacy	efficacy	NOUN
gs-4062	283	4	,	,	PUNCT
gs-4062	283	5	tolerability	tolerability	NOUN
gs-4062	283	6	,	,	PUNCT
gs-4062	283	7	and	and	CCONJ
gs-4062	283	8	high	high	ADJ
gs-4062	283	9	genetic	genetic	ADJ
gs-4062	283	10	barrier	barrier	NOUN
gs-4062	283	11	to	to	ADP
gs-4062	283	12	resistance	resistance	NOUN
gs-4062	283	13	of	of	ADP
gs-4062	283	14	dolutegravir	dolutegravir	PROPN
gs-4062	283	15	-	-	PUNCT
gs-4062	283	16	based	base	VERB
gs-4062	283	17	regimens	regimen	NOUN
gs-4062	283	18	led	lead	VERB
gs-4062	283	19	the	the	DET
gs-4062	283	20	world	world	PROPN
gs-4062	283	21	health	health	NOUN
gs-4062	283	22	organization	organization	NOUN
gs-4062	283	23	to	to	PART
gs-4062	283	24	recommend	recommend	VERB
gs-4062	283	25	them	they	PRON
gs-4062	283	26	as	as	ADP
gs-4062	283	27	the	the	DET
gs-4062	283	28	preferred	preferred	ADJ
gs-4062	283	29	first	first	ADJ
gs-4062	283	30	-	-	PUNCT
gs-4062	283	31	line	line	NOUN
gs-4062	283	32	treatment	treatment	NOUN
gs-4062	283	33	globally	globally	ADV
gs-4062	283	34	.	.	PUNCT
gs-4062	284	1	the	the	DET
gs-4062	284	2	result	result	NOUN
gs-4062	284	3	has	have	AUX
gs-4062	284	4	been	be	AUX
gs-4062	284	5	a	a	DET
gs-4062	284	6	rapid	rapid	ADJ
gs-4062	284	7	scale	scale	NOUN
gs-4062	284	8	-	-	PUNCT
gs-4062	284	9	up	up	NOUN
gs-4062	284	10	across	across	ADP
gs-4062	284	11	lowand	lowand	ADJ
gs-4062	284	12	middle	middle	ADJ
gs-4062	284	13	-	-	PUNCT
gs-4062	284	14	income	income	NOUN
gs-4062	284	15	countries	country	NOUN
gs-4062	284	16	,	,	PUNCT
gs-4062	284	17	a	a	DET
gs-4062	284	18	monumental	monumental	ADJ
gs-4062	284	19	achievement	achievement	NOUN
gs-4062	284	20	in	in	ADP
gs-4062	284	21	global	global	ADJ
gs-4062	284	22	health	health	NOUN
gs-4062	284	23	.	.	PUNCT
gs-4062	285	1	however	however	ADV
gs-4062	285	2	,	,	PUNCT
gs-4062	285	3	this	this	DET
gs-4062	285	4	success	success	NOUN
gs-4062	285	5	has	have	AUX
gs-4062	285	6	been	be	AUX
gs-4062	285	7	tempered	temper	VERB
gs-4062	285	8	by	by	ADP
gs-4062	285	9	the	the	DET
gs-4062	285	10	aforementioned	aforementioned	ADJ
gs-4062	285	11	results	result	NOUN
gs-4062	285	12	concerning	concern	VERB
gs-4062	285	13	weight	weight	NOUN
gs-4062	285	14	gain	gain	NOUN
gs-4062	285	15	,	,	PUNCT
gs-4062	285	16	which	which	PRON
gs-4062	285	17	has	have	VERB
gs-4062	285	18	a	a	DET
gs-4062	285	19	different	different	ADJ
gs-4062	285	20	risk	risk	NOUN
gs-4062	285	21	-	-	PUNCT
gs-4062	285	22	benefit	benefit	NOUN
gs-4062	285	23	calculus	calculus	NOUN
gs-4062	285	24	in	in	ADP
gs-4062	285	25	populations	population	NOUN
gs-4062	285	26	with	with	ADP
gs-4062	285	27	higher	high	ADJ
gs-4062	285	28	background	background	NOUN
gs-4062	285	29	rates	rate	NOUN
gs-4062	285	30	of	of	ADP
gs-4062	285	31	obesity	obesity	NOUN
gs-4062	285	32	and	and	CCONJ
gs-4062	285	33	metabolic	metabolic	NOUN
gs-4062	285	34	disease	disease	NOUN
gs-4062	285	35	.	.	PUNCT
gs-4062	286	1	furthermore	furthermore	ADV
gs-4062	286	2	,	,	PUNCT
gs-4062	286	3	the	the	DET
gs-4062	286	4	high	high	ADJ
gs-4062	286	5	cost	cost	NOUN
gs-4062	286	6	of	of	ADP
gs-4062	286	7	the	the	DET
gs-4062	286	8	newest	new	ADJ
gs-4062	286	9	agents	agent	NOUN
gs-4062	286	10	,	,	PUNCT
gs-4062	286	11	such	such	ADJ
gs-4062	286	12	as	as	ADP
gs-4062	286	13	long	long	ADV
gs-4062	286	14	-	-	PUNCT
gs-4062	286	15	acting	act	VERB
gs-4062	286	16	injectables	injectable	NOUN
gs-4062	286	17	and	and	CCONJ
gs-4062	286	18	novel	novel	ADJ
gs-4062	286	19	classes	class	NOUN
gs-4062	286	20	like	like	ADP
gs-4062	286	21	capsid	capsid	ADJ
gs-4062	286	22	inhibitors	inhibitor	NOUN
gs-4062	286	23	,	,	PUNCT
gs-4062	286	24	creates	create	VERB
gs-4062	286	25	a	a	DET
gs-4062	286	26	significant	significant	ADJ
gs-4062	286	27	access	access	NOUN
gs-4062	286	28	disparity	disparity	NOUN
gs-4062	286	29	.	.	PUNCT
gs-4062	287	1	the	the	DET
gs-4062	287	2	result	result	NOUN
gs-4062	287	3	is	be	AUX
gs-4062	287	4	a	a	DET
gs-4062	287	5	two	two	NUM
gs-4062	287	6	-	-	PUNCT
gs-4062	287	7	tiered	tiere	VERB
gs-4062	287	8	system	system	NOUN
gs-4062	287	9	:	:	PUNCT
gs-4062	287	10	robust	robust	ADJ
gs-4062	287	11	,	,	PUNCT
gs-4062	287	12	simple	simple	ADJ
gs-4062	287	13	,	,	PUNCT
gs-4062	287	14	and	and	CCONJ
gs-4062	287	15	effective	effective	ADJ
gs-4062	287	16	regimens	regimen	NOUN
gs-4062	287	17	for	for	ADP
gs-4062	287	18	the	the	DET
gs-4062	287	19	majority	majority	NOUN
gs-4062	287	20	in	in	ADP
gs-4062	287	21	resource	resource	NOUN
gs-4062	287	22	-	-	PUNCT
gs-4062	287	23	rich	rich	ADJ
gs-4062	287	24	settings	setting	NOUN
gs-4062	287	25	,	,	PUNCT
gs-4062	287	26	and	and	CCONJ
gs-4062	287	27	a	a	DET
gs-4062	287	28	more	more	ADV
gs-4062	287	29	limited	limited	ADJ
gs-4062	287	30	set	set	NOUN
gs-4062	287	31	of	of	ADP
gs-4062	287	32	options	option	NOUN
gs-4062	287	33	for	for	ADP
gs-4062	287	34	the	the	DET
gs-4062	287	35	highly	highly	ADV
gs-4062	287	36	treatment	treatment	NOUN
gs-4062	287	37	-	-	PUNCT
gs-4062	287	38	experienced	experience	VERB
gs-4062	287	39	and	and	CCONJ
gs-4062	287	40	those	those	PRON
gs-4062	287	41	in	in	ADP
gs-4062	287	42	resource	resource	NOUN
gs-4062	287	43	-	-	PUNCT
gs-4062	287	44	limited	limit	VERB
gs-4062	287	45	settings	setting	NOUN
gs-4062	287	46	.	.	PUNCT
gs-4062	288	1	this	this	DET
gs-4062	288	2	inequity	inequity	NOUN
gs-4062	288	3	is	be	AUX
gs-4062	288	4	a	a	DET
gs-4062	288	5	critical	critical	ADJ
gs-4062	288	6	result	result	NOUN
gs-4062	288	7	of	of	ADP
gs-4062	288	8	market	market	NOUN
gs-4062	288	9	forces	force	NOUN
gs-4062	288	10	and	and	CCONJ
gs-4062	288	11	intellectual	intellectual	ADJ
gs-4062	288	12	property	property	NOUN
gs-4062	288	13	regimes	regime	NOUN
gs-4062	288	14	that	that	PRON
gs-4062	288	15	must	must	AUX
gs-4062	288	16	be	be	AUX
gs-4062	288	17	addressed	address	VERB
gs-4062	288	18	through	through	ADP
gs-4062	288	19	aggressive	aggressive	ADJ
gs-4062	288	20	negotiation	negotiation	NOUN
gs-4062	288	21	,	,	PUNCT
gs-4062	288	22	generic	generic	ADJ
gs-4062	288	23	licensing	licensing	NOUN
gs-4062	288	24	,	,	PUNCT
gs-4062	288	25	and	and	CCONJ
gs-4062	288	26	international	international	ADJ
gs-4062	288	27	cooperation	cooperation	NOUN
gs-4062	288	28	.	.	PUNCT
gs-4062	289	1	looking	look	VERB
gs-4062	289	2	forward	forward	ADV
gs-4062	289	3	,	,	PUNCT
gs-4062	289	4	the	the	DET
gs-4062	289	5	results	result	NOUN
gs-4062	289	6	of	of	ADP
gs-4062	289	7	current	current	ADJ
gs-4062	289	8	research	research	NOUN
gs-4062	289	9	are	be	AUX
gs-4062	289	10	already	already	ADV
gs-4062	289	11	pointing	point	VERB
gs-4062	289	12	to	to	ADP
gs-4062	289	13	the	the	DET
gs-4062	289	14	next	next	ADJ
gs-4062	289	15	frontiers	frontier	NOUN
gs-4062	289	16	in	in	ADP
gs-4062	289	17	antiretroviral	antiretroviral	ADJ
gs-4062	289	18	therapy	therapy	NOUN
gs-4062	289	19	.	.	PUNCT
gs-4062	290	1	the	the	DET
gs-4062	290	2	success	success	NOUN
gs-4062	290	3	of	of	ADP
gs-4062	290	4	long	long	ADV
gs-4062	290	5	-	-	PUNCT
gs-4062	290	6	acting	act	VERB
gs-4062	290	7	cabotegravir	cabotegravir	NOUN
gs-4062	290	8	for	for	ADP
gs-4062	290	9	pre	pre	ADJ
gs-4062	290	10	-	-	ADJ
gs-4062	290	11	exposure	exposure	ADJ
gs-4062	290	12	prophylaxis	prophylaxis	NOUN
gs-4062	290	13	is	be	AUX
gs-4062	290	14	a	a	DET
gs-4062	290	15	result	result	NOUN
gs-4062	290	16	that	that	PRON
gs-4062	290	17	proves	prove	VERB
gs-4062	290	18	the	the	DET
gs-4062	290	19	concept	concept	NOUN
gs-4062	290	20	of	of	ADP
gs-4062	290	21	using	use	VERB
gs-4062	290	22	ultra	ultra	ADJ
gs-4062	290	23	-	-	ADJ
gs-4062	290	24	long	long	ADV
gs-4062	290	25	-	-	PUNCT
gs-4062	290	26	acting	act	VERB
gs-4062	290	27	agents	agent	NOUN
gs-4062	290	28	for	for	ADP
gs-4062	290	29	prevention	prevention	NOUN
gs-4062	290	30	,	,	PUNCT
gs-4062	290	31	a	a	DET
gs-4062	290	32	finding	finding	NOUN
gs-4062	290	33	that	that	PRON
gs-4062	290	34	could	could	AUX
gs-4062	290	35	profoundly	profoundly	ADV
gs-4062	290	36	impact	impact	VERB
gs-4062	290	37	incidence	incidence	NOUN
gs-4062	290	38	rates	rate	NOUN
gs-4062	290	39	if	if	SCONJ
gs-4062	290	40	deployed	deploy	VERB
gs-4062	290	41	effectively	effectively	ADV
gs-4062	290	42	in	in	ADP
gs-4062	290	43	high	high	ADJ
gs-4062	290	44	-	-	PUNCT
gs-4062	290	45	risk	risk	NOUN
gs-4062	290	46	populations	population	NOUN
gs-4062	290	47	.	.	PUNCT
gs-4062	291	1	furthermore	furthermore	ADV
gs-4062	291	2	,	,	PUNCT
gs-4062	291	3	the	the	DET
gs-4062	291	4	ability	ability	NOUN
gs-4062	291	5	of	of	ADP
gs-4062	291	6	novel	novel	ADJ
gs-4062	291	7	agents	agent	NOUN
gs-4062	291	8	like	like	ADP
gs-4062	291	9	lenacapavir	lenacapavir	NOUN
gs-4062	291	10	to	to	PART
gs-4062	291	11	potently	potently	ADV
gs-4062	291	12	suppress	suppress	VERB
gs-4062	291	13	virus	virus	NOUN
gs-4062	291	14	in	in	ADP
gs-4062	291	15	deep	deep	ADJ
gs-4062	291	16	tissue	tissue	NOUN
gs-4062	291	17	reservoirs	reservoir	NOUN
gs-4062	291	18	is	be	AUX
gs-4062	291	19	generating	generate	VERB
gs-4062	291	20	discussion	discussion	NOUN
gs-4062	291	21	about	about	ADP
gs-4062	291	22	their	their	PRON
gs-4062	291	23	potential	potential	ADJ
gs-4062	291	24	role	role	NOUN
gs-4062	291	25	in	in	ADP
gs-4062	291	26	cure	cure	NOUN
gs-4062	291	27	strategies	strategy	NOUN
gs-4062	291	28	,	,	PUNCT
gs-4062	291	29	perhaps	perhaps	ADV
gs-4062	291	30	as	as	ADP
gs-4062	291	31	tools	tool	NOUN
gs-4062	291	32	to	to	PART
gs-4062	291	33	prevent	prevent	VERB
gs-4062	291	34	viral	viral	ADJ
gs-4062	291	35	rebound	rebound	NOUN
gs-4062	291	36	during	during	ADP
gs-4062	291	37	treatment	treatment	NOUN
gs-4062	291	38	interruptions	interruption	NOUN
gs-4062	291	39	or	or	CCONJ
gs-4062	291	40	in	in	ADP
gs-4062	291	41	combination	combination	NOUN
gs-4062	291	42	with	with	ADP
gs-4062	291	43	other	other	ADJ
gs-4062	291	44	latency	latency	NOUN
gs-4062	291	45	-	-	PUNCT
gs-4062	291	46	reversing	reverse	VERB
gs-4062	291	47	agents	agent	NOUN
gs-4062	291	48	.	.	PUNCT
gs-4062	292	1	the	the	DET
gs-4062	292	2	result	result	NOUN
gs-4062	292	3	of	of	ADP
gs-4062	292	4	these	these	DET
gs-4062	292	5	inquiries	inquiry	NOUN
gs-4062	292	6	is	be	AUX
gs-4062	292	7	not	not	PART
gs-4062	292	8	yet	yet	ADV
gs-4062	292	9	known	know	VERB
gs-4062	292	10	,	,	PUNCT
gs-4062	292	11	but	but	CCONJ
gs-4062	292	12	they	they	PRON
gs-4062	292	13	represent	represent	VERB
gs-4062	292	14	the	the	DET
gs-4062	292	15	logical	logical	ADJ
gs-4062	292	16	progression	progression	NOUN
gs-4062	292	17	of	of	ADP
gs-4062	292	18	a	a	DET
gs-4062	292	19	field	field	NOUN
gs-4062	292	20	that	that	PRON
gs-4062	292	21	continues	continue	VERB
gs-4062	292	22	to	to	PART
gs-4062	292	23	innovate	innovate	VERB
gs-4062	292	24	relentlessly	relentlessly	ADV
gs-4062	292	25	.	.	PUNCT
gs-4062	293	1	in	in	ADP
gs-4062	293	2	synthesizing	synthesize	VERB
gs-4062	293	3	these	these	DET
gs-4062	293	4	myriad	myriad	ADJ
gs-4062	293	5	results	result	NOUN
gs-4062	293	6	,	,	PUNCT
gs-4062	293	7	the	the	DET
gs-4062	293	8	overarching	overarching	ADJ
gs-4062	293	9	discussion	discussion	NOUN
gs-4062	293	10	concludes	conclude	VERB
gs-4062	293	11	that	that	SCONJ
gs-4062	293	12	the	the	DET
gs-4062	293	13	current	current	ADJ
gs-4062	293	14	era	era	NOUN
gs-4062	293	15	of	of	ADP
gs-4062	293	16	antiretroviral	antiretroviral	ADJ
gs-4062	293	17	therapy	therapy	NOUN
gs-4062	293	18	is	be	AUX
gs-4062	293	19	defined	define	VERB
gs-4062	293	20	by	by	ADP
gs-4062	293	21	an	an	DET
gs-4062	293	22	embarrassment	embarrassment	NOUN
gs-4062	293	23	of	of	ADP
gs-4062	293	24	riches	rich	NOUN
gs-4062	293	25	.	.	PUNCT
gs-4062	294	1	clinicians	clinician	NOUN
gs-4062	294	2	and	and	CCONJ
gs-4062	294	3	patients	patient	NOUN
gs-4062	294	4	now	now	ADV
gs-4062	294	5	have	have	VERB
gs-4062	294	6	access	access	NOUN
gs-4062	294	7	to	to	ADP
gs-4062	294	8	multiple	multiple	ADJ
gs-4062	294	9	regimens	regimen	NOUN
gs-4062	294	10	that	that	PRON
gs-4062	294	11	are	be	AUX
gs-4062	294	12	more	more	ADV
gs-4062	294	13	potent	potent	ADJ
gs-4062	294	14	,	,	PUNCT
gs-4062	294	15	safer	safe	ADJ
gs-4062	294	16	,	,	PUNCT
gs-4062	294	17	and	and	CCONJ
gs-4062	294	18	more	more	ADV
gs-4062	294	19	convenient	convenient	ADJ
gs-4062	294	20	than	than	ADP
gs-4062	294	21	at	at	ADP
gs-4062	294	22	any	any	DET
gs-4062	294	23	previous	previous	ADJ
gs-4062	294	24	time	time	NOUN
gs-4062	294	25	in	in	ADP
gs-4062	294	26	the	the	DET
gs-4062	294	27	history	history	NOUN
gs-4062	294	28	of	of	ADP
gs-4062	294	29	the	the	DET
gs-4062	294	30	epidemic	epidemic	NOUN
gs-4062	294	31	.	.	PUNCT
gs-4062	295	1	the	the	DET
gs-4062	295	2	results	result	NOUN
gs-4062	295	3	demonstrate	demonstrate	VERB
gs-4062	295	4	that	that	SCONJ
gs-4062	295	5	the	the	DET
gs-4062	295	6	historical	historical	ADJ
gs-4062	295	7	toxicities	toxicity	NOUN
gs-4062	295	8	georgian	georgian	VERB
gs-4062	295	9	scientists/	scientists/	NUM
gs-4062	295	10	.	.	PUNCT
gs-4062	296	1	7	7	NUM
gs-4062	296	2	n	n	PRON
gs-4062	296	3	3	3	NUM
gs-4062	296	4	,	,	PUNCT
gs-4062	296	5	2025	2025	NUM
gs-4062	296	6	535	535	NUM
gs-4062	296	7	of	of	ADP
gs-4062	296	8	hiv	hiv	PROPN
gs-4062	296	9	therapy	therapy	NOUN
gs-4062	296	10	—	—	PUNCT
gs-4062	296	11	peripheral	peripheral	ADJ
gs-4062	296	12	neuropathy	neuropathy	ADJ
gs-4062	296	13	,	,	PUNCT
gs-4062	296	14	pancreatic	pancreatic	ADJ
gs-4062	296	15	inflammation	inflammation	NOUN
gs-4062	296	16	,	,	PUNCT
gs-4062	296	17	severe	severe	ADJ
gs-4062	296	18	lipodystrophy	lipodystrophy	NOUN
gs-4062	296	19	,	,	PUNCT
gs-4062	296	20	and	and	CCONJ
gs-4062	296	21	renal	renal	ADJ
gs-4062	296	22	tubular	tubular	ADJ
gs-4062	296	23	damage	damage	NOUN
gs-4062	296	24	—	—	PUNCT
gs-4062	296	25	have	have	AUX
gs-4062	296	26	been	be	AUX
gs-4062	296	27	largely	largely	ADV
gs-4062	296	28	consigned	consign	VERB
gs-4062	296	29	to	to	ADP
gs-4062	296	30	the	the	DET
gs-4062	296	31	past	past	NOUN
gs-4062	296	32	.	.	PUNCT
gs-4062	297	1	they	they	PRON
gs-4062	297	2	have	have	AUX
gs-4062	297	3	been	be	AUX
gs-4062	297	4	replaced	replace	VERB
gs-4062	297	5	by	by	ADP
gs-4062	297	6	a	a	DET
gs-4062	297	7	new	new	ADJ
gs-4062	297	8	set	set	NOUN
gs-4062	297	9	of	of	ADP
gs-4062	297	10	considerations	consideration	NOUN
gs-4062	297	11	,	,	PUNCT
gs-4062	297	12	such	such	ADJ
gs-4062	297	13	as	as	ADP
gs-4062	297	14	managing	manage	VERB
gs-4062	297	15	weight	weight	NOUN
gs-4062	297	16	gain	gain	NOUN
gs-4062	297	17	and	and	CCONJ
gs-4062	297	18	understanding	understand	VERB
gs-4062	297	19	the	the	DET
gs-4062	297	20	long	long	ADJ
gs-4062	297	21	-	-	PUNCT
gs-4062	297	22	term	term	NOUN
gs-4062	297	23	implications	implication	NOUN
gs-4062	297	24	of	of	ADP
gs-4062	297	25	insti	insti	NOUN
gs-4062	297	26	use	use	NOUN
gs-4062	297	27	over	over	ADP
gs-4062	297	28	decades	decade	NOUN
gs-4062	297	29	.	.	PUNCT
gs-4062	298	1	the	the	DET
gs-4062	298	2	central	central	ADJ
gs-4062	298	3	challenge	challenge	NOUN
gs-4062	298	4	has	have	AUX
gs-4062	298	5	shifted	shift	VERB
gs-4062	298	6	from	from	ADP
gs-4062	298	7	achieving	achieve	VERB
gs-4062	298	8	suppression	suppression	NOUN
gs-4062	298	9	to	to	ADP
gs-4062	298	10	choosing	choose	VERB
gs-4062	298	11	the	the	DET
gs-4062	298	12	right	right	ADJ
gs-4062	298	13	suppression	suppression	NOUN
gs-4062	298	14	strategy	strategy	NOUN
gs-4062	298	15	from	from	ADP
gs-4062	298	16	a	a	DET
gs-4062	298	17	menu	menu	NOUN
gs-4062	298	18	of	of	ADP
gs-4062	298	19	excellent	excellent	ADJ
gs-4062	298	20	options	option	NOUN
gs-4062	298	21	,	,	PUNCT
gs-4062	298	22	personalized	personalize	VERB
gs-4062	298	23	to	to	ADP
gs-4062	298	24	the	the	DET
gs-4062	298	25	individual	individual	ADJ
gs-4062	298	26	patient	patient	NOUN
gs-4062	298	27	’s	’s	PART
gs-4062	298	28	needs	need	NOUN
gs-4062	298	29	,	,	PUNCT
gs-4062	298	30	comorbidities	comorbiditie	NOUN
gs-4062	298	31	,	,	PUNCT
gs-4062	298	32	and	and	CCONJ
gs-4062	298	33	lifestyle	lifestyle	NOUN
gs-4062	298	34	.	.	PUNCT
gs-4062	299	1	these	these	DET
gs-4062	299	2	results	result	NOUN
gs-4062	299	3	are	be	AUX
gs-4062	299	4	a	a	DET
gs-4062	299	5	testament	testament	NOUN
gs-4062	299	6	to	to	ADP
gs-4062	299	7	four	four	NUM
gs-4062	299	8	decades	decade	NOUN
gs-4062	299	9	of	of	ADP
gs-4062	299	10	scientific	scientific	ADJ
gs-4062	299	11	perseverance	perseverance	NOUN
gs-4062	299	12	and	and	CCONJ
gs-4062	299	13	a	a	DET
gs-4062	299	14	promise	promise	NOUN
gs-4062	299	15	of	of	ADP
gs-4062	299	16	continued	continue	VERB
gs-4062	299	17	improvement	improvement	NOUN
gs-4062	299	18	in	in	ADP
gs-4062	299	19	the	the	DET
gs-4062	299	20	lives	life	NOUN
gs-4062	299	21	of	of	ADP
gs-4062	299	22	people	people	NOUN
gs-4062	299	23	living	live	VERB
gs-4062	299	24	with	with	ADP
gs-4062	299	25	hiv	hiv	PROPN
gs-4062	299	26	.	.	PUNCT
gs-4062	300	1	the	the	DET
gs-4062	300	2	landscape	landscape	NOUN
gs-4062	300	3	of	of	ADP
gs-4062	300	4	antiretroviral	antiretroviral	ADJ
gs-4062	300	5	therapy	therapy	NOUN
gs-4062	300	6	continues	continue	VERB
gs-4062	300	7	to	to	PART
gs-4062	300	8	evolve	evolve	VERB
gs-4062	300	9	at	at	ADP
gs-4062	300	10	an	an	DET
gs-4062	300	11	unprecedented	unprecedented	ADJ
gs-4062	300	12	pace	pace	NOUN
gs-4062	300	13	,	,	PUNCT
gs-4062	300	14	moving	move	VERB
gs-4062	300	15	beyond	beyond	ADP
gs-4062	300	16	the	the	DET
gs-4062	300	17	paradigm	paradigm	NOUN
gs-4062	300	18	of	of	ADP
gs-4062	300	19	viral	viral	ADJ
gs-4062	300	20	suppression	suppression	NOUN
gs-4062	300	21	to	to	ADP
gs-4062	300	22	a	a	DET
gs-4062	300	23	holistic	holistic	ADJ
gs-4062	300	24	focus	focus	NOUN
gs-4062	300	25	on	on	ADP
gs-4062	300	26	holistic	holistic	ADJ
gs-4062	300	27	patient	patient	NOUN
gs-4062	300	28	wellness	wellness	NOUN
gs-4062	300	29	,	,	PUNCT
gs-4062	300	30	long	long	ADJ
gs-4062	300	31	-	-	PUNCT
gs-4062	300	32	term	term	NOUN
gs-4062	300	33	physiological	physiological	ADJ
gs-4062	300	34	resilience	resilience	NOUN
gs-4062	300	35	,	,	PUNCT
gs-4062	300	36	and	and	CCONJ
gs-4062	300	37	the	the	DET
gs-4062	300	38	eradication	eradication	NOUN
gs-4062	300	39	of	of	ADP
gs-4062	300	40	stigma	stigma	NOUN
gs-4062	300	41	through	through	ADP
gs-4062	300	42	revolutionary	revolutionary	ADJ
gs-4062	300	43	drug	drug	NOUN
gs-4062	300	44	delivery	delivery	NOUN
gs-4062	300	45	systems	system	NOUN
gs-4062	300	46	.	.	PUNCT
gs-4062	301	1	the	the	DET
gs-4062	301	2	results	result	NOUN
gs-4062	301	3	emanating	emanate	VERB
gs-4062	301	4	from	from	ADP
gs-4062	301	5	a	a	DET
gs-4062	301	6	comprehensive	comprehensive	ADJ
gs-4062	301	7	synthesis	synthesis	NOUN
gs-4062	301	8	of	of	ADP
gs-4062	301	9	late	late	ADJ
gs-4062	301	10	-	-	PUNCT
gs-4062	301	11	phase	phase	NOUN
gs-4062	301	12	clinical	clinical	ADJ
gs-4062	301	13	trials	trial	NOUN
gs-4062	301	14	,	,	PUNCT
gs-4062	301	15	advanced	advanced	ADJ
gs-4062	301	16	pharmacological	pharmacological	ADJ
gs-4062	301	17	modeling	modeling	NOUN
gs-4062	301	18	,	,	PUNCT
gs-4062	301	19	and	and	CCONJ
gs-4062	301	20	expansive	expansive	ADJ
gs-4062	301	21	real	real	ADJ
gs-4062	301	22	-	-	PUNCT
gs-4062	301	23	world	world	NOUN
gs-4062	301	24	data	datum	NOUN
gs-4062	301	25	analytics	analytic	NOUN
gs-4062	301	26	reveal	reveal	VERB
gs-4062	301	27	a	a	DET
gs-4062	301	28	new	new	ADJ
gs-4062	301	29	era	era	NOUN
gs-4062	301	30	defined	define	VERB
gs-4062	301	31	by	by	ADP
gs-4062	301	32	ultra	ultra	ADJ
gs-4062	301	33	-	-	ADJ
gs-4062	301	34	long	long	ADV
gs-4062	301	35	-	-	PUNCT
gs-4062	301	36	acting	act	VERB
gs-4062	301	37	formulations	formulation	NOUN
gs-4062	301	38	,	,	PUNCT
gs-4062	301	39	novel	novel	ADJ
gs-4062	301	40	multi	multi	ADJ
gs-4062	301	41	-	-	ADJ
gs-4062	301	42	stage	stage	ADJ
gs-4062	301	43	mechanistic	mechanistic	ADJ
gs-4062	301	44	targets	target	NOUN
gs-4062	301	45	,	,	PUNCT
gs-4062	301	46	and	and	CCONJ
gs-4062	301	47	a	a	DET
gs-4062	301	48	deepened	deepened	ADJ
gs-4062	301	49	understanding	understanding	NOUN
gs-4062	301	50	of	of	ADP
gs-4062	301	51	host	host	NOUN
gs-4062	301	52	-	-	PUNCT
gs-4062	301	53	pathogen	pathogen	NOUN
gs-4062	301	54	-	-	PUNCT
gs-4062	301	55	drug	drug	NOUN
gs-4062	301	56	interactions	interaction	NOUN
gs-4062	301	57	.	.	PUNCT
gs-4062	302	1	this	this	DET
gs-4062	302	2	discussion	discussion	NOUN
gs-4062	302	3	will	will	AUX
gs-4062	302	4	weave	weave	VERB
gs-4062	302	5	together	together	ADV
gs-4062	302	6	these	these	DET
gs-4062	302	7	complex	complex	ADJ
gs-4062	302	8	findings	finding	NOUN
gs-4062	302	9	,	,	PUNCT
gs-4062	302	10	examining	examine	VERB
gs-4062	302	11	the	the	DET
gs-4062	302	12	profound	profound	ADJ
gs-4062	302	13	outcomes	outcome	NOUN
gs-4062	302	14	associated	associate	VERB
gs-4062	302	15	with	with	ADP
gs-4062	302	16	these	these	DET
gs-4062	302	17	next	next	ADJ
gs-4062	302	18	-	-	PUNCT
gs-4062	302	19	generation	generation	NOUN
gs-4062	302	20	therapeutics	therapeutic	NOUN
gs-4062	302	21	,	,	PUNCT
gs-4062	302	22	while	while	SCONJ
gs-4062	302	23	critically	critically	ADV
gs-4062	302	24	engaging	engage	VERB
gs-4062	302	25	with	with	ADP
gs-4062	302	26	the	the	DET
gs-4062	302	27	nuanced	nuanced	ADJ
gs-4062	302	28	challenges	challenge	NOUN
gs-4062	302	29	of	of	ADP
gs-4062	302	30	cellular	cellular	ADJ
gs-4062	302	31	toxicity	toxicity	NOUN
gs-4062	302	32	,	,	PUNCT
gs-4062	302	33	socioeconomic	socioeconomic	ADJ
gs-4062	302	34	access	access	NOUN
gs-4062	302	35	inequities	inequity	NOUN
gs-4062	302	36	,	,	PUNCT
gs-4062	302	37	and	and	CCONJ
gs-4062	302	38	the	the	DET
gs-4062	302	39	emerging	emerge	VERB
gs-4062	302	40	role	role	NOUN
gs-4062	302	41	of	of	ADP
gs-4062	302	42	artificial	artificial	ADJ
gs-4062	302	43	intelligence	intelligence	NOUN
gs-4062	302	44	in	in	ADP
gs-4062	302	45	personalized	personalize	VERB
gs-4062	302	46	hiv	hiv	PROPN
gs-4062	302	47	medicine	medicine	NOUN
gs-4062	302	48	.	.	PUNCT
gs-4062	303	1	the	the	DET
gs-4062	303	2	conversation	conversation	NOUN
gs-4062	303	3	has	have	AUX
gs-4062	303	4	expanded	expand	VERB
gs-4062	303	5	from	from	ADP
gs-4062	303	6	merely	merely	ADV
gs-4062	303	7	controlling	control	VERB
gs-4062	303	8	a	a	DET
gs-4062	303	9	virus	virus	NOUN
gs-4062	303	10	to	to	PART
gs-4062	303	11	comprehensively	comprehensively	ADV
gs-4062	303	12	managing	manage	VERB
gs-4062	303	13	a	a	DET
gs-4062	303	14	chronic	chronic	ADJ
gs-4062	303	15	condition	condition	NOUN
gs-4062	303	16	with	with	ADP
gs-4062	303	17	an	an	DET
gs-4062	303	18	eye	eye	NOUN
gs-4062	303	19	towards	towards	ADP
gs-4062	303	20	future	future	ADJ
gs-4062	303	21	curative	curative	ADJ
gs-4062	303	22	strategies	strategy	NOUN
gs-4062	303	23	.	.	PUNCT
gs-4062	304	1	a	a	DET
gs-4062	304	2	paramount	paramount	ADJ
gs-4062	304	3	result	result	NOUN
gs-4062	304	4	reshaping	reshape	VERB
gs-4062	304	5	first	first	ADJ
gs-4062	304	6	-	-	PUNCT
gs-4062	304	7	line	line	NOUN
gs-4062	304	8	treatment	treatment	NOUN
gs-4062	304	9	guidelines	guideline	NOUN
gs-4062	304	10	globally	globally	ADV
gs-4062	304	11	is	be	AUX
gs-4062	304	12	the	the	DET
gs-4062	304	13	solidified	solidify	VERB
gs-4062	304	14	superiority	superiority	NOUN
gs-4062	304	15	of	of	ADP
gs-4062	304	16	second	second	ADJ
gs-4062	304	17	-	-	PUNCT
gs-4062	304	18	generation	generation	NOUN
gs-4062	304	19	integrase	integrase	NOUN
gs-4062	304	20	strand	strand	NOUN
gs-4062	304	21	transfer	transfer	NOUN
gs-4062	304	22	inhibitors	inhibitor	NOUN
gs-4062	304	23	,	,	PUNCT
gs-4062	304	24	particularly	particularly	ADV
gs-4062	304	25	dolutegravir	dolutegravir	PROPN
gs-4062	304	26	and	and	CCONJ
gs-4062	304	27	bictegravir	bictegravir	NOUN
gs-4062	304	28	,	,	PUNCT
gs-4062	304	29	and	and	CCONJ
gs-4062	304	30	the	the	DET
gs-4062	304	31	emerging	emerge	VERB
gs-4062	304	32	data	datum	NOUN
gs-4062	304	33	on	on	ADP
gs-4062	304	34	their	their	PRON
gs-4062	304	35	successor	successor	NOUN
gs-4062	304	36	,	,	PUNCT
gs-4062	304	37	cabotegravir	cabotegravir	VERB
gs-4062	304	38	in	in	ADP
gs-4062	304	39	oral	oral	ADJ
gs-4062	304	40	form	form	NOUN
gs-4062	304	41	.	.	PUNCT
gs-4062	305	1	long	long	ADJ
gs-4062	305	2	-	-	PUNCT
gs-4062	305	3	term	term	NOUN
gs-4062	305	4	extension	extension	NOUN
gs-4062	305	5	studies	study	NOUN
gs-4062	305	6	spanning	span	VERB
gs-4062	305	7	five	five	NUM
gs-4062	305	8	years	year	NOUN
gs-4062	305	9	and	and	CCONJ
gs-4062	305	10	beyond	beyond	ADP
gs-4062	305	11	now	now	ADV
gs-4062	305	12	provide	provide	VERB
gs-4062	305	13	a	a	DET
gs-4062	305	14	robust	robust	ADJ
gs-4062	305	15	dataset	dataset	NOUN
gs-4062	305	16	demonstrating	demonstrating	NOUN
gs-4062	305	17	not	not	PART
gs-4062	305	18	just	just	ADV
gs-4062	305	19	sustained	sustain	VERB
gs-4062	305	20	virological	virological	ADJ
gs-4062	305	21	efficacy	efficacy	NOUN
gs-4062	305	22	but	but	CCONJ
gs-4062	305	23	a	a	DET
gs-4062	305	24	remarkable	remarkable	ADJ
gs-4062	305	25	preservation	preservation	NOUN
gs-4062	305	26	of	of	ADP
gs-4062	305	27	physiological	physiological	ADJ
gs-4062	305	28	function	function	NOUN
gs-4062	305	29	.	.	PUNCT
gs-4062	306	1	the	the	DET
gs-4062	306	2	discussion	discussion	NOUN
gs-4062	306	3	around	around	ADP
gs-4062	306	4	these	these	DET
gs-4062	306	5	results	result	NOUN
gs-4062	306	6	must	must	AUX
gs-4062	306	7	highlight	highlight	VERB
gs-4062	306	8	the	the	DET
gs-4062	306	9	concept	concept	NOUN
gs-4062	306	10	of	of	ADP
gs-4062	306	11	"	"	PUNCT
gs-4062	306	12	metabolic	metabolic	NOUN
gs-4062	306	13	neutrality	neutrality	NOUN
gs-4062	306	14	"	"	PUNCT
gs-4062	306	15	observed	observe	VERB
gs-4062	306	16	with	with	ADP
gs-4062	306	17	bictegravir	bictegravir	PROPN
gs-4062	306	18	-	-	PUNCT
gs-4062	306	19	based	base	VERB
gs-4062	306	20	regimens	regimen	NOUN
gs-4062	306	21	;	;	PUNCT
gs-4062	306	22	unlike	unlike	ADP
gs-4062	306	23	earlier	early	ADJ
gs-4062	306	24	regimens	regimen	NOUN
gs-4062	306	25	which	which	PRON
gs-4062	306	26	often	often	ADV
gs-4062	306	27	contributed	contribute	VERB
gs-4062	306	28	to	to	PART
gs-4062	306	29	dyslipidemia	dyslipidemia	VERB
gs-4062	306	30	or	or	CCONJ
gs-4062	306	31	insulin	insulin	NOUN
gs-4062	306	32	resistance	resistance	NOUN
gs-4062	306	33	,	,	PUNCT
gs-4062	306	34	these	these	DET
gs-4062	306	35	modern	modern	ADJ
gs-4062	306	36	cores	core	NOUN
gs-4062	306	37	show	show	VERB
gs-4062	306	38	minimal	minimal	ADJ
gs-4062	306	39	to	to	ADP
gs-4062	306	40	no	no	DET
gs-4062	306	41	deleterious	deleterious	ADJ
gs-4062	306	42	impact	impact	NOUN
gs-4062	306	43	on	on	ADP
gs-4062	306	44	lipid	lipid	ADJ
gs-4062	306	45	profiles	profile	NOUN
gs-4062	306	46	,	,	PUNCT
gs-4062	306	47	glycemic	glycemic	ADJ
gs-4062	306	48	markers	marker	NOUN
gs-4062	306	49	,	,	PUNCT
gs-4062	306	50	or	or	CCONJ
gs-4062	306	51	other	other	ADJ
gs-4062	306	52	metabolic	metabolic	NOUN
gs-4062	306	53	parameters	parameter	NOUN
gs-4062	306	54	over	over	ADP
gs-4062	306	55	extended	extended	ADJ
gs-4062	306	56	periods	period	NOUN
gs-4062	306	57	.	.	PUNCT
gs-4062	307	1	this	this	PRON
gs-4062	307	2	is	be	AUX
gs-4062	307	3	a	a	DET
gs-4062	307	4	critical	critical	ADJ
gs-4062	307	5	result	result	NOUN
gs-4062	307	6	for	for	ADP
gs-4062	307	7	long	long	ADJ
gs-4062	307	8	-	-	PUNCT
gs-4062	307	9	term	term	NOUN
gs-4062	307	10	cardiovascular	cardiovascular	ADJ
gs-4062	307	11	health	health	NOUN
gs-4062	307	12	,	,	PUNCT
gs-4062	307	13	a	a	DET
gs-4062	307	14	leading	lead	VERB
gs-4062	307	15	concern	concern	NOUN
gs-4062	307	16	in	in	ADP
gs-4062	307	17	an	an	DET
gs-4062	307	18	aging	age	VERB
gs-4062	307	19	hiv	hiv	NOUN
gs-4062	307	20	-	-	PUNCT
gs-4062	307	21	positive	positive	ADJ
gs-4062	307	22	population	population	NOUN
gs-4062	307	23	.	.	PUNCT
gs-4062	308	1	furthermore	furthermore	ADV
gs-4062	308	2	,	,	PUNCT
gs-4062	308	3	pharmaco	pharmaco	NOUN
gs-4062	308	4	-	-	PUNCT
gs-4062	308	5	economic	economic	ADJ
gs-4062	308	6	modeling	modeling	NOUN
gs-4062	308	7	results	result	NOUN
gs-4062	308	8	indicate	indicate	VERB
gs-4062	308	9	that	that	SCONJ
gs-4062	308	10	despite	despite	SCONJ
gs-4062	308	11	higher	high	ADJ
gs-4062	308	12	drug	drug	NOUN
gs-4062	308	13	acquisition	acquisition	NOUN
gs-4062	308	14	costs	cost	NOUN
gs-4062	308	15	,	,	PUNCT
gs-4062	308	16	the	the	DET
gs-4062	308	17	superior	superior	ADJ
gs-4062	308	18	barrier	barrier	NOUN
gs-4062	308	19	to	to	ADP
gs-4062	308	20	resistance	resistance	NOUN
gs-4062	308	21	and	and	CCONJ
gs-4062	308	22	reduced	reduce	VERB
gs-4062	308	23	need	need	NOUN
gs-4062	308	24	for	for	ADP
gs-4062	308	25	costly	costly	ADJ
gs-4062	308	26	resistance	resistance	NOUN
gs-4062	308	27	testing	testing	NOUN
gs-4062	308	28	and	and	CCONJ
gs-4062	308	29	regimen	regimen	NOUN
gs-4062	308	30	switches	switch	NOUN
gs-4062	308	31	make	make	VERB
gs-4062	308	32	these	these	DET
gs-4062	308	33	agents	agent	NOUN
gs-4062	308	34	cost	cost	NOUN
gs-4062	308	35	-	-	PUNCT
gs-4062	308	36	effective	effective	ADJ
gs-4062	308	37	or	or	CCONJ
gs-4062	308	38	even	even	ADV
gs-4062	308	39	cost	cost	NOUN
gs-4062	308	40	-	-	PUNCT
gs-4062	308	41	saving	saving	NOUN
gs-4062	308	42	from	from	ADP
gs-4062	308	43	a	a	DET
gs-4062	308	44	systems	system	NOUN
gs-4062	308	45	perspective	perspective	NOUN
gs-4062	308	46	over	over	ADP
gs-4062	308	47	a	a	DET
gs-4062	308	48	patient	patient	NOUN
gs-4062	308	49	's	's	PART
gs-4062	308	50	lifetime	lifetime	NOUN
gs-4062	308	51	.	.	PUNCT
gs-4062	309	1	this	this	DET
gs-4062	309	2	result	result	NOUN
gs-4062	309	3	is	be	AUX
gs-4062	309	4	fundamentally	fundamentally	ADV
gs-4062	309	5	changing	change	VERB
gs-4062	309	6	how	how	SCONJ
gs-4062	309	7	governments	government	NOUN
gs-4062	309	8	and	and	CCONJ
gs-4062	309	9	health	health	NOUN
gs-4062	309	10	insurers	insurer	NOUN
gs-4062	309	11	evaluate	evaluate	VERB
gs-4062	309	12	and	and	CCONJ
gs-4062	309	13	fund	fund	VERB
gs-4062	309	14	hiv	hiv	PROPN
gs-4062	309	15	treatment	treatment	NOUN
gs-4062	309	16	programs	program	NOUN
gs-4062	309	17	,	,	PUNCT
gs-4062	309	18	viewing	view	VERB
gs-4062	309	19	it	it	PRON
gs-4062	309	20	as	as	ADP
gs-4062	309	21	a	a	DET
gs-4062	309	22	long	long	ADJ
gs-4062	309	23	-	-	PUNCT
gs-4062	309	24	term	term	NOUN
gs-4062	309	25	investment	investment	NOUN
gs-4062	309	26	in	in	ADP
gs-4062	309	27	population	population	NOUN
gs-4062	309	28	health	health	NOUN
gs-4062	309	29	.	.	PUNCT
gs-4062	310	1	the	the	DET
gs-4062	310	2	most	most	ADV
gs-4062	310	3	revolutionary	revolutionary	ADJ
gs-4062	310	4	results	result	NOUN
gs-4062	310	5	,	,	PUNCT
gs-4062	310	6	however	however	ADV
gs-4062	310	7	,	,	PUNCT
gs-4062	310	8	lie	lie	VERB
gs-4062	310	9	in	in	ADP
gs-4062	310	10	the	the	DET
gs-4062	310	11	domain	domain	NOUN
gs-4062	310	12	of	of	ADP
gs-4062	310	13	long	long	ADV
gs-4062	310	14	-	-	PUNCT
gs-4062	310	15	acting	act	VERB
gs-4062	310	16	antiretroviral	antiretroviral	ADJ
gs-4062	310	17	therapy	therapy	NOUN
gs-4062	310	18	,	,	PUNCT
gs-4062	310	19	which	which	PRON
gs-4062	310	20	has	have	AUX
gs-4062	310	21	transitioned	transition	VERB
gs-4062	310	22	from	from	ADP
gs-4062	310	23	a	a	DET
gs-4062	310	24	theoretical	theoretical	ADJ
gs-4062	310	25	concept	concept	NOUN
gs-4062	310	26	to	to	ADP
gs-4062	310	27	a	a	DET
gs-4062	310	28	clinically	clinically	ADV
gs-4062	310	29	validated	validate	VERB
gs-4062	310	30	reality	reality	NOUN
gs-4062	310	31	.	.	PUNCT
gs-4062	311	1	the	the	DET
gs-4062	311	2	outcomes	outcome	NOUN
gs-4062	311	3	from	from	ADP
gs-4062	311	4	the	the	DET
gs-4062	311	5	phase	phase	NOUN
gs-4062	311	6	iii	iii	NUM
gs-4062	311	7	trials	trial	NOUN
gs-4062	311	8	for	for	ADP
gs-4062	311	9	long	long	ADV
gs-4062	311	10	-	-	PUNCT
gs-4062	311	11	acting	act	VERB
gs-4062	311	12	cabotegravir	cabotegravir	NOUN
gs-4062	311	13	and	and	CCONJ
gs-4062	311	14	rilpivirine	rilpivirine	VERB
gs-4062	311	15	injections	injection	NOUN
gs-4062	311	16	have	have	AUX
gs-4062	311	17	been	be	AUX
gs-4062	311	18	successfully	successfully	ADV
gs-4062	311	19	replicated	replicate	VERB
gs-4062	311	20	in	in	ADP
gs-4062	311	21	diverse	diverse	ADJ
gs-4062	311	22	real	real	ADJ
gs-4062	311	23	-	-	PUNCT
gs-4062	311	24	world	world	NOUN
gs-4062	311	25	settings	setting	NOUN
gs-4062	311	26	,	,	PUNCT
gs-4062	311	27	often	often	ADV
gs-4062	311	28	referred	refer	VERB
gs-4062	311	29	to	to	ADP
gs-4062	311	30	as	as	ADP
gs-4062	311	31	"	"	PUNCT
gs-4062	311	32	implementation	implementation	NOUN
gs-4062	311	33	science	science	NOUN
gs-4062	311	34	"	"	PUNCT
gs-4062	311	35	studies	study	NOUN
gs-4062	311	36	.	.	PUNCT
gs-4062	312	1	these	these	DET
gs-4062	312	2	results	result	NOUN
gs-4062	312	3	demonstrate	demonstrate	VERB
gs-4062	312	4	that	that	SCONJ
gs-4062	312	5	high	high	ADJ
gs-4062	312	6	levels	level	NOUN
gs-4062	312	7	of	of	ADP
gs-4062	312	8	virological	virological	ADJ
gs-4062	312	9	suppression	suppression	NOUN
gs-4062	312	10	can	can	AUX
gs-4062	312	11	be	be	AUX
gs-4062	312	12	maintained	maintain	VERB
gs-4062	312	13	outside	outside	ADP
gs-4062	312	14	the	the	DET
gs-4062	312	15	rigid	rigid	ADJ
gs-4062	312	16	protocol	protocol	NOUN
gs-4062	312	17	of	of	ADP
gs-4062	312	18	a	a	DET
gs-4062	312	19	clinical	clinical	ADJ
gs-4062	312	20	trial	trial	NOUN
gs-4062	312	21	,	,	PUNCT
gs-4062	312	22	with	with	ADP
gs-4062	312	23	careful	careful	ADJ
gs-4062	312	24	patient	patient	ADJ
gs-4062	312	25	selection	selection	NOUN
gs-4062	312	26	and	and	CCONJ
gs-4062	312	27	management	management	NOUN
gs-4062	312	28	.	.	PUNCT
gs-4062	313	1	a	a	DET
gs-4062	313	2	deeper	deep	ADJ
gs-4062	313	3	discussion	discussion	NOUN
gs-4062	313	4	point	point	NOUN
gs-4062	313	5	emerging	emerge	VERB
gs-4062	313	6	from	from	ADP
gs-4062	313	7	this	this	DET
gs-4062	313	8	data	data	NOUN
gs-4062	313	9	is	be	AUX
gs-4062	313	10	the	the	DET
gs-4062	313	11	psychological	psychological	ADJ
gs-4062	313	12	result	result	NOUN
gs-4062	313	13	of	of	ADP
gs-4062	313	14	decoupling	decouple	VERB
gs-4062	313	15	hiv	hiv	PROPN
gs-4062	313	16	management	management	NOUN
gs-4062	313	17	from	from	ADP
gs-4062	313	18	daily	daily	ADJ
gs-4062	313	19	oral	oral	ADJ
gs-4062	313	20	medication	medication	NOUN
gs-4062	313	21	.	.	PUNCT
gs-4062	314	1	qualitative	qualitative	ADJ
gs-4062	314	2	research	research	NOUN
gs-4062	314	3	sub	sub	NOUN
gs-4062	314	4	-	-	NOUN
gs-4062	314	5	studies	study	NOUN
gs-4062	314	6	report	report	VERB
gs-4062	314	7	a	a	DET
gs-4062	314	8	profound	profound	ADJ
gs-4062	314	9	reduction	reduction	NOUN
gs-4062	314	10	in	in	ADP
gs-4062	314	11	georgian	georgian	PROPN
gs-4062	314	12	scientists/	scientists/	NUM
gs-4062	314	13	.	.	PUNCT
gs-4062	315	1	7	7	NUM
gs-4062	315	2	n	n	PRON
gs-4062	315	3	3	3	NUM
gs-4062	315	4	,	,	PUNCT
gs-4062	315	5	2025	2025	NUM
gs-4062	315	6	536	536	NUM
gs-4062	315	7	internalized	internalize	VERB
gs-4062	315	8	stigma	stigma	NOUN
gs-4062	315	9	and	and	CCONJ
gs-4062	315	10	an	an	DET
gs-4062	315	11	improved	improved	ADJ
gs-4062	315	12	sense	sense	NOUN
gs-4062	315	13	of	of	ADP
gs-4062	315	14	normalcy	normalcy	NOUN
gs-4062	315	15	among	among	ADP
gs-4062	315	16	recipients	recipient	NOUN
gs-4062	315	17	of	of	ADP
gs-4062	315	18	injectable	injectable	ADJ
gs-4062	315	19	therapy	therapy	NOUN
gs-4062	315	20	.	.	PUNCT
gs-4062	316	1	the	the	DET
gs-4062	316	2	act	act	NOUN
gs-4062	316	3	of	of	ADP
gs-4062	316	4	taking	take	VERB
gs-4062	316	5	a	a	DET
gs-4062	316	6	daily	daily	ADJ
gs-4062	316	7	pill	pill	NOUN
gs-4062	316	8	,	,	PUNCT
gs-4062	316	9	a	a	DET
gs-4062	316	10	constant	constant	ADJ
gs-4062	316	11	reminder	reminder	NOUN
gs-4062	316	12	of	of	ADP
gs-4062	316	13	one	one	NUM
gs-4062	316	14	's	's	PART
gs-4062	316	15	serostatus	serostatus	NOUN
gs-4062	316	16	,	,	PUNCT
gs-4062	316	17	is	be	AUX
gs-4062	316	18	eliminated	eliminate	VERB
gs-4062	316	19	,	,	PUNCT
gs-4062	316	20	leading	lead	VERB
gs-4062	316	21	to	to	ADP
gs-4062	316	22	measurable	measurable	ADJ
gs-4062	316	23	improvements	improvement	NOUN
gs-4062	316	24	in	in	ADP
gs-4062	316	25	mental	mental	ADJ
gs-4062	316	26	health	health	NOUN
gs-4062	316	27	outcomes	outcome	NOUN
gs-4062	316	28	and	and	CCONJ
gs-4062	316	29	overall	overall	ADJ
gs-4062	316	30	quality	quality	NOUN
gs-4062	316	31	-	-	PUNCT
gs-4062	316	32	of	of	ADP
gs-4062	316	33	-	-	PUNCT
gs-4062	316	34	life	life	NOUN
gs-4062	316	35	scores	score	NOUN
gs-4062	316	36	.	.	PUNCT
gs-4062	317	1	this	this	PRON
gs-4062	317	2	represents	represent	VERB
gs-4062	317	3	a	a	DET
gs-4062	317	4	paradigm	paradigm	NOUN
gs-4062	317	5	shift	shift	NOUN
gs-4062	317	6	in	in	ADP
gs-4062	317	7	evaluating	evaluate	VERB
gs-4062	317	8	treatment	treatment	NOUN
gs-4062	317	9	success	success	NOUN
gs-4062	317	10	,	,	PUNCT
gs-4062	317	11	moving	move	VERB
gs-4062	317	12	beyond	beyond	ADP
gs-4062	317	13	bio	bio	ADJ
gs-4062	317	14	-	-	ADJ
gs-4062	317	15	clinical	clinical	ADJ
gs-4062	317	16	markers	marker	NOUN
gs-4062	317	17	to	to	PART
gs-4062	317	18	encompass	encompass	VERB
gs-4062	317	19	profound	profound	ADJ
gs-4062	317	20	psychosocial	psychosocial	ADJ
gs-4062	317	21	benefits	benefit	NOUN
gs-4062	317	22	.	.	PUNCT
gs-4062	318	1	concurrently	concurrently	ADV
gs-4062	318	2	,	,	PUNCT
gs-4062	318	3	the	the	DET
gs-4062	318	4	results	result	NOUN
gs-4062	318	5	from	from	ADP
gs-4062	318	6	pre	pre	ADJ
gs-4062	318	7	-	-	ADJ
gs-4062	318	8	exposure	exposure	ADJ
gs-4062	318	9	prophylaxis	prophylaxis	ADJ
gs-4062	318	10	studies	study	NOUN
gs-4062	318	11	using	use	VERB
gs-4062	318	12	long	long	ADV
gs-4062	318	13	-	-	PUNCT
gs-4062	318	14	acting	act	VERB
gs-4062	318	15	cabotegravir	cabotegravir	NOUN
gs-4062	318	16	are	be	AUX
gs-4062	318	17	arguably	arguably	ADV
gs-4062	318	18	among	among	ADP
gs-4062	318	19	the	the	DET
gs-4062	318	20	most	most	ADV
gs-4062	318	21	significant	significant	ADJ
gs-4062	318	22	public	public	ADJ
gs-4062	318	23	health	health	NOUN
gs-4062	318	24	advancements	advancement	NOUN
gs-4062	318	25	in	in	ADP
gs-4062	318	26	hiv	hiv	PROPN
gs-4062	318	27	prevention	prevention	NOUN
gs-4062	318	28	.	.	PUNCT
gs-4062	319	1	the	the	DET
gs-4062	319	2	efficacy	efficacy	NOUN
gs-4062	319	3	results	result	VERB
gs-4062	319	4	,	,	PUNCT
gs-4062	319	5	demonstrating	demonstrate	VERB
gs-4062	319	6	a	a	DET
gs-4062	319	7	superior	superior	ADJ
gs-4062	319	8	level	level	NOUN
gs-4062	319	9	of	of	ADP
gs-4062	319	10	protection	protection	NOUN
gs-4062	319	11	compared	compare	VERB
gs-4062	319	12	to	to	ADP
gs-4062	319	13	daily	daily	ADJ
gs-4062	319	14	oral	oral	ADJ
gs-4062	319	15	prep	prep	NOUN
gs-4062	319	16	,	,	PUNCT
gs-4062	319	17	particularly	particularly	ADV
gs-4062	319	18	in	in	ADP
gs-4062	319	19	populations	population	NOUN
gs-4062	319	20	where	where	SCONJ
gs-4062	319	21	adherence	adherence	NOUN
gs-4062	319	22	to	to	ADP
gs-4062	319	23	a	a	DET
gs-4062	319	24	daily	daily	ADJ
gs-4062	319	25	pill	pill	NOUN
gs-4062	319	26	is	be	AUX
gs-4062	319	27	challenging	challenging	ADJ
gs-4062	319	28	,	,	PUNCT
gs-4062	319	29	offer	offer	VERB
gs-4062	319	30	a	a	DET
gs-4062	319	31	powerful	powerful	ADJ
gs-4062	319	32	tool	tool	NOUN
gs-4062	319	33	to	to	PART
gs-4062	319	34	curb	curb	VERB
gs-4062	319	35	incidence	incidence	NOUN
gs-4062	319	36	rates	rate	NOUN
gs-4062	319	37	.	.	PUNCT
gs-4062	320	1	the	the	DET
gs-4062	320	2	discussion	discussion	NOUN
gs-4062	320	3	must	must	AUX
gs-4062	320	4	focus	focus	VERB
gs-4062	320	5	on	on	ADP
gs-4062	320	6	the	the	DET
gs-4062	320	7	implementation	implementation	NOUN
gs-4062	320	8	results	result	NOUN
gs-4062	320	9	,	,	PUNCT
gs-4062	320	10	which	which	PRON
gs-4062	320	11	highlight	highlight	VERB
gs-4062	320	12	the	the	DET
gs-4062	320	13	challenges	challenge	NOUN
gs-4062	320	14	and	and	CCONJ
gs-4062	320	15	opportunities	opportunity	NOUN
gs-4062	320	16	of	of	ADP
gs-4062	320	17	rolling	roll	VERB
gs-4062	320	18	out	out	ADP
gs-4062	320	19	such	such	DET
gs-4062	320	20	a	a	DET
gs-4062	320	21	technology	technology	NOUN
gs-4062	320	22	.	.	PUNCT
gs-4062	321	1	results	result	NOUN
gs-4062	321	2	from	from	ADP
gs-4062	321	3	pilot	pilot	NOUN
gs-4062	321	4	programs	program	NOUN
gs-4062	321	5	indicate	indicate	VERB
gs-4062	321	6	the	the	DET
gs-4062	321	7	necessity	necessity	NOUN
gs-4062	321	8	of	of	ADP
gs-4062	321	9	building	build	VERB
gs-4062	321	10	robust	robust	ADJ
gs-4062	321	11	infrastructure	infrastructure	NOUN
gs-4062	321	12	for	for	ADP
gs-4062	321	13	injection	injection	NOUN
gs-4062	321	14	delivery	delivery	NOUN
gs-4062	321	15	,	,	PUNCT
gs-4062	321	16	managing	manage	VERB
gs-4062	321	17	minor	minor	ADJ
gs-4062	321	18	but	but	CCONJ
gs-4062	321	19	common	common	ADJ
gs-4062	321	20	side	side	NOUN
gs-4062	321	21	effects	effect	NOUN
gs-4062	321	22	like	like	ADP
gs-4062	321	23	injection	injection	NOUN
gs-4062	321	24	site	site	NOUN
gs-4062	321	25	reactions	reaction	NOUN
gs-4062	321	26	,	,	PUNCT
gs-4062	321	27	and	and	CCONJ
gs-4062	321	28	addressing	address	VERB
gs-4062	321	29	the	the	DET
gs-4062	321	30	unique	unique	ADJ
gs-4062	321	31	issue	issue	NOUN
gs-4062	321	32	of	of	ADP
gs-4062	321	33	"	"	PUNCT
gs-4062	321	34	tail	tail	NOUN
gs-4062	321	35	"	"	PUNCT
gs-4062	321	36	pharmacokinetics	pharmacokinetic	NOUN
gs-4062	321	37	—	—	PUNCT
gs-4062	321	38	the	the	DET
gs-4062	321	39	long	long	ADJ
gs-4062	321	40	period	period	NOUN
gs-4062	321	41	of	of	ADP
gs-4062	321	42	time	time	NOUN
gs-4062	321	43	after	after	ADP
gs-4062	321	44	the	the	DET
gs-4062	321	45	last	last	ADJ
gs-4062	321	46	injection	injection	NOUN
gs-4062	321	47	where	where	SCONJ
gs-4062	321	48	drug	drug	NOUN
gs-4062	321	49	levels	level	NOUN
gs-4062	321	50	remain	remain	VERB
gs-4062	321	51	subtherapeutic	subtherapeutic	ADJ
gs-4062	321	52	but	but	CCONJ
gs-4062	321	53	detectable	detectable	ADJ
gs-4062	321	54	,	,	PUNCT
gs-4062	321	55	potentially	potentially	ADV
gs-4062	321	56	fostering	foster	VERB
gs-4062	321	57	resistance	resistance	NOUN
gs-4062	321	58	if	if	SCONJ
gs-4062	321	59	infection	infection	NOUN
gs-4062	321	60	occurs	occur	VERB
gs-4062	321	61	.	.	PUNCT
gs-4062	322	1	this	this	PRON
gs-4062	322	2	has	have	AUX
gs-4062	322	3	spurred	spur	VERB
gs-4062	322	4	innovative	innovative	ADJ
gs-4062	322	5	research	research	NOUN
gs-4062	322	6	into	into	ADP
gs-4062	322	7	real	real	ADJ
gs-4062	322	8	-	-	PUNCT
gs-4062	322	9	time	time	NOUN
gs-4062	322	10	adherence	adherence	NOUN
gs-4062	322	11	monitoring	monitoring	NOUN
gs-4062	322	12	using	use	VERB
gs-4062	322	13	digital	digital	ADJ
gs-4062	322	14	health	health	NOUN
gs-4062	322	15	technologies	technology	NOUN
gs-4062	322	16	and	and	CCONJ
gs-4062	322	17	the	the	DET
gs-4062	322	18	development	development	NOUN
gs-4062	322	19	of	of	ADP
gs-4062	322	20	predictive	predictive	ADJ
gs-4062	322	21	algorithms	algorithm	NOUN
gs-4062	322	22	to	to	PART
gs-4062	322	23	personalize	personalize	VERB
gs-4062	322	24	injection	injection	NOUN
gs-4062	322	25	schedules	schedule	NOUN
gs-4062	322	26	.	.	PUNCT
gs-4062	323	1	the	the	DET
gs-4062	323	2	frontier	frontier	NOUN
gs-4062	323	3	of	of	ADP
gs-4062	323	4	antiretroviral	antiretroviral	ADJ
gs-4062	323	5	development	development	NOUN
gs-4062	323	6	has	have	AUX
gs-4062	323	7	been	be	AUX
gs-4062	323	8	boldly	boldly	ADV
gs-4062	323	9	advanced	advanced	ADJ
gs-4062	323	10	with	with	ADP
gs-4062	323	11	the	the	DET
gs-4062	323	12	arrival	arrival	NOUN
gs-4062	323	13	of	of	ADP
gs-4062	323	14	agents	agent	NOUN
gs-4062	323	15	possessing	possess	VERB
gs-4062	323	16	entirely	entirely	ADV
gs-4062	323	17	novel	novel	ADJ
gs-4062	323	18	mechanisms	mechanism	NOUN
gs-4062	323	19	,	,	PUNCT
gs-4062	323	20	most	most	ADV
gs-4062	323	21	notably	notably	ADV
gs-4062	323	22	the	the	DET
gs-4062	323	23	capsid	capsid	ADJ
gs-4062	323	24	inhibitors	inhibitor	NOUN
gs-4062	323	25	.	.	PUNCT
gs-4062	324	1	the	the	DET
gs-4062	324	2	clinical	clinical	ADJ
gs-4062	324	3	results	result	NOUN
gs-4062	324	4	for	for	ADP
gs-4062	324	5	lenacapavir	lenacapavir	NOUN
gs-4062	324	6	are	be	AUX
gs-4062	324	7	groundbreaking	groundbreake	VERB
gs-4062	324	8	,	,	PUNCT
gs-4062	324	9	especially	especially	ADV
gs-4062	324	10	for	for	ADP
gs-4062	324	11	the	the	DET
gs-4062	324	12	highly	highly	ADV
gs-4062	324	13	treatment	treatment	NOUN
gs-4062	324	14	-	-	PUNCT
gs-4062	324	15	experienced	experience	VERB
gs-4062	324	16	population	population	NOUN
gs-4062	324	17	.	.	PUNCT
gs-4062	325	1	what	what	PRON
gs-4062	325	2	is	be	AUX
gs-4062	325	3	most	most	ADV
gs-4062	325	4	remarkable	remarkable	ADJ
gs-4062	325	5	is	be	AUX
gs-4062	325	6	the	the	DET
gs-4062	325	7	rapidity	rapidity	NOUN
gs-4062	325	8	and	and	CCONJ
gs-4062	325	9	depth	depth	NOUN
gs-4062	325	10	of	of	ADP
gs-4062	325	11	viral	viral	ADJ
gs-4062	325	12	load	load	NOUN
gs-4062	325	13	decline	decline	NOUN
gs-4062	325	14	observed	observe	VERB
gs-4062	325	15	even	even	ADV
gs-4062	325	16	in	in	ADP
gs-4062	325	17	patients	patient	NOUN
gs-4062	325	18	with	with	ADP
gs-4062	325	19	extensive	extensive	ADJ
gs-4062	325	20	resistance	resistance	NOUN
gs-4062	325	21	to	to	ADP
gs-4062	325	22	all	all	DET
gs-4062	325	23	other	other	ADJ
gs-4062	325	24	drug	drug	NOUN
gs-4062	325	25	classes	class	NOUN
gs-4062	325	26	.	.	PUNCT
gs-4062	326	1	this	this	DET
gs-4062	326	2	result	result	NOUN
gs-4062	326	3	is	be	AUX
gs-4062	326	4	directly	directly	ADV
gs-4062	326	5	attributable	attributable	ADJ
gs-4062	326	6	to	to	ADP
gs-4062	326	7	its	its	PRON
gs-4062	326	8	unique	unique	ADJ
gs-4062	326	9	mechanism	mechanism	NOUN
gs-4062	326	10	,	,	PUNCT
gs-4062	326	11	which	which	PRON
gs-4062	326	12	results	result	VERB
gs-4062	326	13	in	in	ADP
gs-4062	326	14	multi	multi	ADJ
gs-4062	326	15	-	-	ADJ
gs-4062	326	16	stage	stage	ADJ
gs-4062	326	17	inhibition	inhibition	NOUN
gs-4062	326	18	of	of	ADP
gs-4062	326	19	the	the	DET
gs-4062	326	20	viral	viral	ADJ
gs-4062	326	21	life	life	NOUN
gs-4062	326	22	cycle	cycle	NOUN
gs-4062	326	23	.	.	PUNCT
gs-4062	327	1	structural	structural	ADJ
gs-4062	327	2	biology	biology	NOUN
gs-4062	327	3	studies	study	NOUN
gs-4062	327	4	have	have	AUX
gs-4062	327	5	yielded	yield	VERB
gs-4062	327	6	results	result	NOUN
gs-4062	327	7	showing	show	VERB
gs-4062	327	8	how	how	SCONJ
gs-4062	327	9	lenacapavir	lenacapavir	NOUN
gs-4062	327	10	stabilizes	stabilize	VERB
gs-4062	327	11	and	and	CCONJ
gs-4062	327	12	hyper	hyper	NOUN
gs-4062	327	13	-	-	VERB
gs-4062	327	14	stabilizes	stabilize	VERB
gs-4062	327	15	the	the	DET
gs-4062	327	16	capsid	capsid	PROPN
gs-4062	327	17	core	core	NOUN
gs-4062	327	18	,	,	PUNCT
gs-4062	327	19	preventing	prevent	VERB
gs-4062	327	20	its	its	PRON
gs-4062	327	21	uncoating	uncoating	NOUN
gs-4062	327	22	and	and	CCONJ
gs-4062	327	23	disrupting	disrupt	VERB
gs-4062	327	24	the	the	DET
gs-4062	327	25	formation	formation	NOUN
gs-4062	327	26	of	of	ADP
gs-4062	327	27	new	new	ADJ
gs-4062	327	28	virions	virion	NOUN
gs-4062	327	29	.	.	PUNCT
gs-4062	328	1	furthermore	furthermore	ADV
gs-4062	328	2	,	,	PUNCT
gs-4062	328	3	its	its	PRON
gs-4062	328	4	pharmacokinetic	pharmacokinetic	ADJ
gs-4062	328	5	profile	profile	NOUN
gs-4062	328	6	is	be	AUX
gs-4062	328	7	unprecedented	unprecedented	ADJ
gs-4062	328	8	;	;	PUNCT
gs-4062	328	9	results	result	NOUN
gs-4062	328	10	show	show	VERB
gs-4062	328	11	sustained	sustained	ADJ
gs-4062	328	12	drug	drug	NOUN
gs-4062	328	13	concentrations	concentration	NOUN
gs-4062	328	14	far	far	ADV
gs-4062	328	15	above	above	ADP
gs-4062	328	16	the	the	DET
gs-4062	328	17	protein	protein	NOUN
gs-4062	328	18	-	-	PUNCT
gs-4062	328	19	adjusted	adjust	VERB
gs-4062	328	20	inhibitory	inhibitory	ADJ
gs-4062	328	21	concentration	concentration	NOUN
gs-4062	328	22	for	for	ADP
gs-4062	328	23	over	over	ADP
gs-4062	328	24	six	six	NUM
gs-4062	328	25	months	month	NOUN
gs-4062	328	26	following	follow	VERB
gs-4062	328	27	a	a	DET
gs-4062	328	28	single	single	ADJ
gs-4062	328	29	subcutaneous	subcutaneous	ADJ
gs-4062	328	30	injection	injection	NOUN
gs-4062	328	31	.	.	PUNCT
gs-4062	329	1	this	this	PRON
gs-4062	329	2	opens	open	VERB
gs-4062	329	3	up	up	ADP
gs-4062	329	4	discussions	discussion	NOUN
gs-4062	329	5	for	for	ADP
gs-4062	329	6	future	future	ADJ
gs-4062	329	7	regimen	regimen	NOUN
gs-4062	329	8	construction	construction	NOUN
gs-4062	329	9	,	,	PUNCT
gs-4062	329	10	potentially	potentially	ADV
gs-4062	329	11	involving	involve	VERB
gs-4062	329	12	dualor	dualor	NOUN
gs-4062	329	13	triple	triple	ADJ
gs-4062	329	14	-	-	PUNCT
gs-4062	329	15	long	long	ADV
gs-4062	329	16	-	-	PUNCT
gs-4062	329	17	acting	act	VERB
gs-4062	329	18	injections	injection	NOUN
gs-4062	329	19	administered	administer	VERB
gs-4062	329	20	semi	semi	ADV
gs-4062	329	21	-	-	ADJ
gs-4062	329	22	annually	annually	ADV
gs-4062	329	23	,	,	PUNCT
gs-4062	329	24	effectively	effectively	ADV
gs-4062	329	25	creating	create	VERB
gs-4062	329	26	a	a	DET
gs-4062	329	27	"	"	PUNCT
gs-4062	329	28	yearly	yearly	ADJ
gs-4062	329	29	regimen	regiman	NOUN
gs-4062	329	30	"	"	PUNCT
gs-4062	329	31	for	for	ADP
gs-4062	329	32	hiv	hiv	PROPN
gs-4062	329	33	.	.	PUNCT
gs-4062	330	1	the	the	DET
gs-4062	330	2	ongoing	ongoing	ADJ
gs-4062	330	3	clinical	clinical	ADJ
gs-4062	330	4	trials	trial	NOUN
gs-4062	330	5	exploring	explore	VERB
gs-4062	330	6	lenacapavir	lenacapavir	NOUN
gs-4062	330	7	in	in	ADP
gs-4062	330	8	treatment	treatment	NOUN
gs-4062	330	9	-	-	PUNCT
gs-4062	330	10	naïve	naïve	ADJ
gs-4062	330	11	patients	patient	NOUN
gs-4062	330	12	and	and	CCONJ
gs-4062	330	13	as	as	ADP
gs-4062	330	14	part	part	NOUN
gs-4062	330	15	of	of	ADP
gs-4062	330	16	long	long	ADV
gs-4062	330	17	-	-	PUNCT
gs-4062	330	18	acting	act	VERB
gs-4062	330	19	combinations	combination	NOUN
gs-4062	330	20	are	be	AUX
gs-4062	330	21	eagerly	eagerly	ADV
gs-4062	330	22	awaited	await	VERB
gs-4062	330	23	,	,	PUNCT
gs-4062	330	24	as	as	SCONJ
gs-4062	330	25	they	they	PRON
gs-4062	330	26	could	could	AUX
gs-4062	330	27	redefine	redefine	VERB
gs-4062	330	28	the	the	DET
gs-4062	330	29	standard	standard	NOUN
gs-4062	330	30	of	of	ADP
gs-4062	330	31	care	care	NOUN
gs-4062	330	32	for	for	ADP
gs-4062	330	33	all	all	DET
gs-4062	330	34	people	people	NOUN
gs-4062	330	35	living	live	VERB
gs-4062	330	36	with	with	ADP
gs-4062	330	37	hiv	hiv	PROPN
gs-4062	330	38	.	.	PUNCT
gs-4062	331	1	another	another	DET
gs-4062	331	2	exciting	exciting	ADJ
gs-4062	331	3	new	new	ADJ
gs-4062	331	4	avenue	avenue	NOUN
gs-4062	331	5	is	be	AUX
gs-4062	331	6	the	the	DET
gs-4062	331	7	development	development	NOUN
gs-4062	331	8	of	of	ADP
gs-4062	331	9	broadly	broadly	ADV
gs-4062	331	10	neutralizing	neutralize	VERB
gs-4062	331	11	antibodies	antibody	NOUN
gs-4062	331	12	(	(	PUNCT
gs-4062	331	13	bnabs	bnab	NOUN
gs-4062	331	14	)	)	PUNCT
gs-4062	331	15	.	.	PUNCT
gs-4062	332	1	while	while	SCONJ
gs-4062	332	2	not	not	PART
gs-4062	332	3	traditional	traditional	ADJ
gs-4062	332	4	small	small	ADJ
gs-4062	332	5	-	-	PUNCT
gs-4062	332	6	molecule	molecule	NOUN
gs-4062	332	7	drugs	drug	NOUN
gs-4062	332	8	,	,	PUNCT
gs-4062	332	9	the	the	DET
gs-4062	332	10	results	result	NOUN
gs-4062	332	11	from	from	ADP
gs-4062	332	12	clinical	clinical	ADJ
gs-4062	332	13	trials	trial	NOUN
gs-4062	332	14	of	of	ADP
gs-4062	332	15	bnabs	bnab	NOUN
gs-4062	332	16	like	like	ADP
gs-4062	332	17	teropavimab	teropavimab	NOUN
gs-4062	332	18	and	and	CCONJ
gs-4062	332	19	zinlirvimab	zinlirvimab	NOUN
gs-4062	332	20	are	be	AUX
gs-4062	332	21	informing	inform	VERB
gs-4062	332	22	a	a	DET
gs-4062	332	23	new	new	ADJ
gs-4062	332	24	class	class	NOUN
gs-4062	332	25	of	of	ADP
gs-4062	332	26	biologics	biologic	NOUN
gs-4062	332	27	for	for	ADP
gs-4062	332	28	hiv	hiv	PROPN
gs-4062	332	29	treatment	treatment	NOUN
gs-4062	332	30	and	and	CCONJ
gs-4062	332	31	prevention	prevention	NOUN
gs-4062	332	32	.	.	PUNCT
gs-4062	333	1	the	the	DET
gs-4062	333	2	discussion	discussion	NOUN
gs-4062	333	3	here	here	ADV
gs-4062	333	4	is	be	AUX
gs-4062	333	5	nuanced	nuanced	ADJ
gs-4062	333	6	.	.	PUNCT
gs-4062	334	1	results	result	NOUN
gs-4062	334	2	show	show	VERB
gs-4062	334	3	that	that	SCONJ
gs-4062	334	4	as	as	ADP
gs-4062	334	5	monotherapy	monotherapy	NOUN
gs-4062	334	6	,	,	PUNCT
gs-4062	334	7	their	their	PRON
gs-4062	334	8	efficacy	efficacy	NOUN
gs-4062	334	9	is	be	AUX
gs-4062	334	10	limited	limit	VERB
gs-4062	334	11	by	by	ADP
gs-4062	334	12	pre	pre	VERB
gs-4062	334	13	-	-	ADJ
gs-4062	334	14	existing	exist	VERB
gs-4062	334	15	or	or	CCONJ
gs-4062	334	16	rapidly	rapidly	ADV
gs-4062	334	17	emerging	emerge	VERB
gs-4062	334	18	resistance	resistance	NOUN
gs-4062	334	19	,	,	PUNCT
gs-4062	334	20	as	as	SCONJ
gs-4062	334	21	hiv	hiv	PROPN
gs-4062	334	22	can	can	AUX
gs-4062	334	23	easily	easily	ADV
gs-4062	334	24	escape	escape	VERB
gs-4062	334	25	the	the	DET
gs-4062	334	26	pressure	pressure	NOUN
gs-4062	334	27	of	of	ADP
gs-4062	334	28	a	a	DET
gs-4062	334	29	single	single	ADJ
gs-4062	334	30	antibody	antibody	NOUN
gs-4062	334	31	.	.	PUNCT
gs-4062	335	1	however	however	ADV
gs-4062	335	2	,	,	PUNCT
gs-4062	335	3	results	result	NOUN
gs-4062	335	4	from	from	ADP
gs-4062	335	5	combination	combination	NOUN
gs-4062	335	6	studies	study	NOUN
gs-4062	335	7	using	use	VERB
gs-4062	335	8	two	two	NUM
gs-4062	335	9	or	or	CCONJ
gs-4062	335	10	three	three	NUM
gs-4062	335	11	bnabs	bnab	NOUN
gs-4062	335	12	targeting	target	VERB
gs-4062	335	13	non	non	ADJ
gs-4062	335	14	-	-	ADJ
gs-4062	335	15	overlapping	overlapping	ADJ
gs-4062	335	16	epitopes	epitope	NOUN
gs-4062	335	17	on	on	ADP
gs-4062	335	18	the	the	DET
gs-4062	335	19	viral	viral	ADJ
gs-4062	335	20	envelope	envelope	NOUN
gs-4062	335	21	are	be	AUX
gs-4062	335	22	highly	highly	ADV
gs-4062	335	23	promising	promising	ADJ
gs-4062	335	24	,	,	PUNCT
gs-4062	335	25	demonstrating	demonstrating	NOUN
gs-4062	335	26	prolonged	prolong	VERB
gs-4062	335	27	virological	virological	ADJ
gs-4062	335	28	suppression	suppression	NOUN
gs-4062	335	29	in	in	ADP
gs-4062	335	30	carefully	carefully	ADV
gs-4062	335	31	selected	select	VERB
gs-4062	335	32	individuals	individual	NOUN
gs-4062	335	33	with	with	ADP
gs-4062	335	34	sensitive	sensitive	ADJ
gs-4062	335	35	virus	virus	NOUN
gs-4062	335	36	.	.	PUNCT
gs-4062	336	1	this	this	PRON
gs-4062	336	2	has	have	AUX
gs-4062	336	3	led	lead	VERB
gs-4062	336	4	to	to	ADP
gs-4062	336	5	a	a	DET
gs-4062	336	6	new	new	ADJ
gs-4062	336	7	field	field	NOUN
gs-4062	336	8	of	of	ADP
gs-4062	336	9	pre	pre	ADJ
gs-4062	336	10	-	-	ADJ
gs-4062	336	11	treatment	treatment	NOUN
gs-4062	336	12	sensitivity	sensitivity	NOUN
gs-4062	336	13	screening	screening	NOUN
gs-4062	336	14	.	.	PUNCT
gs-4062	337	1	the	the	DET
gs-4062	337	2	most	most	ADV
gs-4062	337	3	exciting	exciting	ADJ
gs-4062	337	4	discussion	discussion	NOUN
gs-4062	337	5	point	point	NOUN
gs-4062	337	6	is	be	AUX
gs-4062	337	7	the	the	DET
gs-4062	337	8	potential	potential	ADJ
gs-4062	337	9	role	role	NOUN
gs-4062	337	10	of	of	ADP
gs-4062	337	11	bnabs	bnab	NOUN
gs-4062	337	12	in	in	ADP
gs-4062	337	13	kick	kick	NOUN
gs-4062	337	14	-	-	PUNCT
gs-4062	337	15	and	and	CCONJ
gs-4062	337	16	-	-	PUNCT
gs-4062	337	17	kill	kill	VERB
gs-4062	337	18	cure	cure	NOUN
gs-4062	337	19	strategies	strategy	NOUN
gs-4062	337	20	.	.	PUNCT
gs-4062	338	1	results	result	NOUN
gs-4062	338	2	from	from	ADP
gs-4062	338	3	animal	animal	NOUN
gs-4062	338	4	models	model	NOUN
gs-4062	338	5	and	and	CCONJ
gs-4062	338	6	early	early	ADJ
gs-4062	338	7	human	human	ADJ
gs-4062	338	8	studies	study	NOUN
gs-4062	338	9	suggest	suggest	VERB
gs-4062	338	10	that	that	SCONJ
gs-4062	338	11	by	by	ADP
gs-4062	338	12	binding	bind	VERB
gs-4062	338	13	to	to	ADP
gs-4062	338	14	the	the	DET
gs-4062	338	15	surface	surface	NOUN
gs-4062	338	16	of	of	ADP
gs-4062	338	17	infected	infected	ADJ
gs-4062	338	18	cells	cell	NOUN
gs-4062	338	19	,	,	PUNCT
gs-4062	338	20	bnabs	bnab	NOUN
gs-4062	338	21	can	can	AUX
gs-4062	338	22	flag	flag	VERB
gs-4062	338	23	them	they	PRON
gs-4062	338	24	for	for	ADP
gs-4062	338	25	destruction	destruction	NOUN
gs-4062	338	26	by	by	ADP
gs-4062	338	27	the	the	DET
gs-4062	338	28	georgian	georgian	PROPN
gs-4062	338	29	scientists/	scientists/	NUM
gs-4062	338	30	.	.	PUNCT
gs-4062	339	1	7	7	NUM
gs-4062	339	2	n	n	PRON
gs-4062	339	3	3	3	NUM
gs-4062	339	4	,	,	PUNCT
gs-4062	339	5	2025	2025	NUM
gs-4062	339	6	537	537	NUM
gs-4062	339	7	immune	immune	ADJ
gs-4062	339	8	system	system	NOUN
gs-4062	339	9	through	through	ADP
gs-4062	339	10	antibody	antibody	NOUN
gs-4062	339	11	-	-	PUNCT
gs-4062	339	12	dependent	dependent	ADJ
gs-4062	339	13	cellular	cellular	ADJ
gs-4062	339	14	cytotoxicity	cytotoxicity	NOUN
gs-4062	339	15	,	,	PUNCT
gs-4062	339	16	potentially	potentially	ADV
gs-4062	339	17	helping	help	VERB
gs-4062	339	18	to	to	PART
gs-4062	339	19	clear	clear	VERB
gs-4062	339	20	the	the	DET
gs-4062	339	21	latent	latent	NOUN
gs-4062	339	22	reservoir	reservoir	NOUN
gs-4062	339	23	.	.	PUNCT
gs-4062	340	1	this	this	PRON
gs-4062	340	2	remains	remain	VERB
gs-4062	340	3	a	a	DET
gs-4062	340	4	nascent	nascent	ADJ
gs-4062	340	5	but	but	CCONJ
gs-4062	340	6	explosively	explosively	ADJ
gs-4062	340	7	growth	growth	NOUN
gs-4062	340	8	-	-	PUNCT
gs-4062	340	9	oriented	orient	VERB
gs-4062	340	10	area	area	NOUN
gs-4062	340	11	of	of	ADP
gs-4062	340	12	research	research	NOUN
gs-4062	340	13	.	.	PUNCT
gs-4062	341	1	despite	despite	SCONJ
gs-4062	341	2	these	these	DET
gs-4062	341	3	spectacular	spectacular	ADJ
gs-4062	341	4	advances	advance	NOUN
gs-4062	341	5	,	,	PUNCT
gs-4062	341	6	the	the	DET
gs-4062	341	7	results	result	NOUN
gs-4062	341	8	of	of	ADP
gs-4062	341	9	widespread	widespread	ADJ
gs-4062	341	10	surveillance	surveillance	NOUN
gs-4062	341	11	have	have	AUX
gs-4062	341	12	brought	bring	VERB
gs-4062	341	13	to	to	ADP
gs-4062	341	14	light	light	NOUN
gs-4062	341	15	more	more	ADV
gs-4062	341	16	detailed	detailed	ADJ
gs-4062	341	17	and	and	CCONJ
gs-4062	341	18	concerning	concern	VERB
gs-4062	341	19	safety	safety	NOUN
gs-4062	341	20	signals	signal	NOUN
gs-4062	341	21	that	that	PRON
gs-4062	341	22	require	require	VERB
gs-4062	341	23	sophisticated	sophisticated	ADJ
gs-4062	341	24	discussion	discussion	NOUN
gs-4062	341	25	.	.	PUNCT
gs-4062	342	1	the	the	DET
gs-4062	342	2	issue	issue	NOUN
gs-4062	342	3	of	of	ADP
gs-4062	342	4	insti	insti	NOUN
gs-4062	342	5	-	-	PUNCT
gs-4062	342	6	associated	associate	VERB
gs-4062	342	7	weight	weight	NOUN
gs-4062	342	8	gain	gain	NOUN
gs-4062	342	9	has	have	AUX
gs-4062	342	10	been	be	AUX
gs-4062	342	11	extensively	extensively	ADV
gs-4062	342	12	studied	study	VERB
gs-4062	342	13	,	,	PUNCT
gs-4062	342	14	and	and	CCONJ
gs-4062	342	15	new	new	ADJ
gs-4062	342	16	results	result	NOUN
gs-4062	342	17	provide	provide	VERB
gs-4062	342	18	greater	great	ADJ
gs-4062	342	19	clarity	clarity	NOUN
gs-4062	342	20	on	on	ADP
gs-4062	342	21	its	its	PRON
gs-4062	342	22	character	character	NOUN
gs-4062	342	23	.	.	PUNCT
gs-4062	343	1	it	it	PRON
gs-4062	343	2	is	be	AUX
gs-4062	343	3	now	now	ADV
gs-4062	343	4	understood	understand	VERB
gs-4062	343	5	to	to	PART
gs-4062	343	6	be	be	AUX
gs-4062	343	7	a	a	DET
gs-4062	343	8	class	class	NOUN
gs-4062	343	9	effect	effect	NOUN
gs-4062	343	10	,	,	PUNCT
gs-4062	343	11	but	but	CCONJ
gs-4062	343	12	with	with	ADP
gs-4062	343	13	varying	vary	VERB
gs-4062	343	14	magnitudes	magnitude	NOUN
gs-4062	343	15	.	.	PUNCT
gs-4062	344	1	weight	weight	NOUN
gs-4062	344	2	gain	gain	NOUN
gs-4062	344	3	appears	appear	VERB
gs-4062	344	4	to	to	PART
gs-4062	344	5	be	be	AUX
gs-4062	344	6	greatest	great	ADJ
gs-4062	344	7	with	with	ADP
gs-4062	344	8	dolutegravir	dolutegravir	PROPN
gs-4062	344	9	and	and	CCONJ
gs-4062	344	10	bictegravir	bictegravir	PROPN
gs-4062	344	11	,	,	PUNCT
gs-4062	344	12	intermediate	intermediate	ADJ
gs-4062	344	13	with	with	ADP
gs-4062	344	14	cabotegravir	cabotegravir	PROPN
gs-4062	344	15	,	,	PUNCT
gs-4062	344	16	and	and	CCONJ
gs-4062	344	17	modest	modest	ADJ
gs-4062	344	18	with	with	ADP
gs-4062	344	19	the	the	DET
gs-4062	344	20	newer	new	ADJ
gs-4062	344	21	insti	insti	NOUN
gs-4062	344	22	,	,	PUNCT
gs-4062	344	23	islatravir	islatravir	NOUN
gs-4062	344	24	.	.	PUNCT
gs-4062	345	1	the	the	DET
gs-4062	345	2	weight	weight	NOUN
gs-4062	345	3	gain	gain	NOUN
gs-4062	345	4	is	be	AUX
gs-4062	345	5	predominantly	predominantly	ADV
gs-4062	345	6	in	in	ADP
gs-4062	345	7	the	the	DET
gs-4062	345	8	visceral	visceral	ADJ
gs-4062	345	9	adipose	adipose	ADJ
gs-4062	345	10	tissue	tissue	NOUN
gs-4062	345	11	compartment	compartment	NOUN
gs-4062	345	12	,	,	PUNCT
gs-4062	345	13	which	which	PRON
gs-4062	345	14	is	be	AUX
gs-4062	345	15	metabolically	metabolically	ADV
gs-4062	345	16	unfavorable	unfavorable	ADJ
gs-4062	345	17	and	and	CCONJ
gs-4062	345	18	associated	associate	VERB
gs-4062	345	19	with	with	ADP
gs-4062	345	20	higher	high	ADJ
gs-4062	345	21	risks	risk	NOUN
gs-4062	345	22	of	of	ADP
gs-4062	345	23	cardiovascular	cardiovascular	ADJ
gs-4062	345	24	disease	disease	NOUN
gs-4062	345	25	and	and	CCONJ
gs-4062	345	26	diabetes	diabetes	NOUN
gs-4062	345	27	.	.	PUNCT
gs-4062	346	1	the	the	DET
gs-4062	346	2	discussion	discussion	NOUN
gs-4062	346	3	has	have	AUX
gs-4062	346	4	moved	move	VERB
gs-4062	346	5	from	from	ADP
gs-4062	346	6	simply	simply	ADV
gs-4062	346	7	documenting	document	VERB
gs-4062	346	8	the	the	DET
gs-4062	346	9	phenomenon	phenomenon	NOUN
gs-4062	346	10	to	to	ADP
gs-4062	346	11	understanding	understand	VERB
gs-4062	346	12	its	its	PRON
gs-4062	346	13	mechanisms	mechanism	NOUN
gs-4062	346	14	.	.	PUNCT
gs-4062	347	1	recent	recent	ADJ
gs-4062	347	2	results	result	NOUN
gs-4062	347	3	from	from	ADP
gs-4062	347	4	in	in	ADP
gs-4062	347	5	vitro	vitro	X
gs-4062	347	6	studies	study	NOUN
gs-4062	347	7	suggest	suggest	VERB
gs-4062	347	8	a	a	DET
gs-4062	347	9	potential	potential	ADJ
gs-4062	347	10	off	off	ADP
gs-4062	347	11	-	-	PUNCT
gs-4062	347	12	target	target	NOUN
gs-4062	347	13	effect	effect	NOUN
gs-4062	347	14	on	on	ADP
gs-4062	347	15	melanocortin-4	melanocortin-4	NUM
gs-4062	347	16	receptor	receptor	NOUN
gs-4062	347	17	signaling	signal	VERB
gs-4062	347	18	,	,	PUNCT
gs-4062	347	19	a	a	DET
gs-4062	347	20	key	key	ADJ
gs-4062	347	21	pathway	pathway	NOUN
gs-4062	347	22	in	in	ADP
gs-4062	347	23	the	the	DET
gs-4062	347	24	hypothalamus	hypothalamus	NOUN
gs-4062	347	25	for	for	ADP
gs-4062	347	26	regulating	regulate	VERB
gs-4062	347	27	appetite	appetite	NOUN
gs-4062	347	28	and	and	CCONJ
gs-4062	347	29	energy	energy	NOUN
gs-4062	347	30	expenditure	expenditure	NOUN
gs-4062	347	31	.	.	PUNCT
gs-4062	348	1	other	other	ADJ
gs-4062	348	2	hypotheses	hypothesis	NOUN
gs-4062	348	3	implicate	implicate	VERB
gs-4062	348	4	effects	effect	NOUN
gs-4062	348	5	on	on	ADP
gs-4062	348	6	adipocyte	adipocyte	ADJ
gs-4062	348	7	differentiation	differentiation	NOUN
gs-4062	348	8	and	and	CCONJ
gs-4062	348	9	lipid	lipid	NOUN
gs-4062	348	10	metabolism	metabolism	NOUN
gs-4062	348	11	.	.	PUNCT
gs-4062	349	1	crucially	crucially	ADV
gs-4062	349	2	,	,	PUNCT
gs-4062	349	3	results	result	VERB
gs-4062	349	4	from	from	ADP
gs-4062	349	5	large	large	ADJ
gs-4062	349	6	cohort	cohort	NOUN
gs-4062	349	7	studies	study	NOUN
gs-4062	349	8	like	like	ADP
gs-4062	349	9	respond	respond	NOUN
gs-4062	349	10	are	be	AUX
gs-4062	349	11	now	now	ADV
gs-4062	349	12	showing	show	VERB
gs-4062	349	13	that	that	SCONJ
gs-4062	349	14	the	the	DET
gs-4062	349	15	weight	weight	NOUN
gs-4062	349	16	trajectory	trajectory	NOUN
gs-4062	349	17	does	do	AUX
gs-4062	349	18	not	not	PART
gs-4062	349	19	plateau	plateau	VERB
gs-4062	349	20	indefinitely	indefinitely	ADV
gs-4062	349	21	but	but	CCONJ
gs-4062	349	22	tends	tend	VERB
gs-4062	349	23	to	to	PART
gs-4062	349	24	slow	slow	VERB
gs-4062	349	25	after	after	ADP
gs-4062	349	26	18	18	NUM
gs-4062	349	27	-	-	SYM
gs-4062	349	28	24	24	NUM
gs-4062	349	29	months	month	NOUN
gs-4062	349	30	.	.	PUNCT
gs-4062	350	1	however	however	ADV
gs-4062	350	2	,	,	PUNCT
gs-4062	350	3	the	the	DET
gs-4062	350	4	clinical	clinical	ADJ
gs-4062	350	5	management	management	NOUN
gs-4062	350	6	of	of	ADP
gs-4062	350	7	this	this	DET
gs-4062	350	8	weight	weight	NOUN
gs-4062	350	9	gain	gain	NOUN
gs-4062	350	10	—	—	PUNCT
gs-4062	350	11	whether	whether	SCONJ
gs-4062	350	12	through	through	ADP
gs-4062	350	13	pharmacological	pharmacological	ADJ
gs-4062	350	14	intervention	intervention	NOUN
gs-4062	350	15	,	,	PUNCT
gs-4062	350	16	switching	switch	VERB
gs-4062	350	17	strategies	strategy	NOUN
gs-4062	350	18	,	,	PUNCT
gs-4062	350	19	or	or	CCONJ
gs-4062	350	20	lifestyle	lifestyle	NOUN
gs-4062	350	21	programs	program	NOUN
gs-4062	350	22	—	—	PUNCT
gs-4062	350	23	remains	remain	VERB
gs-4062	350	24	an	an	DET
gs-4062	350	25	area	area	NOUN
gs-4062	350	26	of	of	ADP
gs-4062	350	27	active	active	ADJ
gs-4062	350	28	investigation	investigation	NOUN
gs-4062	350	29	and	and	CCONJ
gs-4062	350	30	debate	debate	NOUN
gs-4062	350	31	.	.	PUNCT
gs-4062	351	1	furthermore	furthermore	ADV
gs-4062	351	2	,	,	PUNCT
gs-4062	351	3	the	the	DET
gs-4062	351	4	neurological	neurological	ADJ
gs-4062	351	5	and	and	CCONJ
gs-4062	351	6	psychiatric	psychiatric	ADJ
gs-4062	351	7	safety	safety	NOUN
gs-4062	351	8	profile	profile	NOUN
gs-4062	351	9	of	of	ADP
gs-4062	351	10	these	these	DET
gs-4062	351	11	drugs	drug	NOUN
gs-4062	351	12	is	be	AUX
gs-4062	351	13	under	under	ADP
gs-4062	351	14	continued	continue	VERB
gs-4062	351	15	scrutiny	scrutiny	NOUN
gs-4062	351	16	.	.	PUNCT
gs-4062	352	1	while	while	SCONJ
gs-4062	352	2	the	the	DET
gs-4062	352	3	initial	initial	ADJ
gs-4062	352	4	fear	fear	NOUN
gs-4062	352	5	surrounding	surround	VERB
gs-4062	352	6	dolutegravir	dolutegravir	NOUN
gs-4062	352	7	and	and	CCONJ
gs-4062	352	8	suicidal	suicidal	ADJ
gs-4062	352	9	ideation	ideation	NOUN
gs-4062	352	10	has	have	AUX
gs-4062	352	11	been	be	AUX
gs-4062	352	12	alleviated	alleviate	VERB
gs-4062	352	13	by	by	ADP
gs-4062	352	14	larger	large	ADJ
gs-4062	352	15	datasets	dataset	NOUN
gs-4062	352	16	showing	show	VERB
gs-4062	352	17	no	no	DET
gs-4062	352	18	overall	overall	ADJ
gs-4062	352	19	increased	increased	ADJ
gs-4062	352	20	risk	risk	NOUN
gs-4062	352	21	,	,	PUNCT
gs-4062	352	22	more	more	ADV
gs-4062	352	23	subtle	subtle	ADJ
gs-4062	352	24	neuropsychiatric	neuropsychiatric	ADJ
gs-4062	352	25	results	result	NOUN
gs-4062	352	26	are	be	AUX
gs-4062	352	27	being	be	AUX
gs-4062	352	28	documented	document	VERB
gs-4062	352	29	.	.	PUNCT
gs-4062	353	1	patient	patient	NOUN
gs-4062	353	2	-	-	PUNCT
gs-4062	353	3	reported	report	VERB
gs-4062	353	4	outcomes	outcome	NOUN
gs-4062	353	5	and	and	CCONJ
gs-4062	353	6	specific	specific	ADJ
gs-4062	353	7	cognitive	cognitive	ADJ
gs-4062	353	8	testing	testing	NOUN
gs-4062	353	9	batteries	battery	NOUN
gs-4062	353	10	reveal	reveal	VERB
gs-4062	353	11	that	that	SCONJ
gs-4062	353	12	a	a	DET
gs-4062	353	13	subset	subset	NOUN
gs-4062	353	14	of	of	ADP
gs-4062	353	15	patients	patient	NOUN
gs-4062	353	16	on	on	ADP
gs-4062	353	17	instis	instis	PROPN
gs-4062	353	18	report	report	VERB
gs-4062	353	19	higher	high	ADJ
gs-4062	353	20	rates	rate	NOUN
gs-4062	353	21	of	of	ADP
gs-4062	353	22	insomnia	insomnia	NOUN
gs-4062	353	23	,	,	PUNCT
gs-4062	353	24	anxiety	anxiety	NOUN
gs-4062	353	25	,	,	PUNCT
gs-4062	353	26	and	and	CCONJ
gs-4062	353	27	subjective	subjective	ADJ
gs-4062	353	28	cognitive	cognitive	ADJ
gs-4062	353	29	complaints	complaint	NOUN
gs-4062	353	30	like	like	ADP
gs-4062	353	31	"	"	PUNCT
gs-4062	353	32	brain	brain	NOUN
gs-4062	353	33	fog	fog	NOUN
gs-4062	353	34	"	"	PUNCT
gs-4062	353	35	compared	compare	VERB
gs-4062	353	36	to	to	ADP
gs-4062	353	37	those	those	PRON
gs-4062	353	38	on	on	ADP
gs-4062	353	39	protease	protease	NOUN
gs-4062	353	40	inhibitor	inhibitor	NOUN
gs-4062	353	41	-	-	PUNCT
gs-4062	353	42	based	base	VERB
gs-4062	353	43	regimens	regimen	NOUN
gs-4062	353	44	.	.	PUNCT
gs-4062	354	1	the	the	DET
gs-4062	354	2	discussion	discussion	NOUN
gs-4062	354	3	here	here	ADV
gs-4062	354	4	is	be	AUX
gs-4062	354	5	complex	complex	ADJ
gs-4062	354	6	,	,	PUNCT
gs-4062	354	7	as	as	SCONJ
gs-4062	354	8	it	it	PRON
gs-4062	354	9	is	be	AUX
gs-4062	354	10	challenging	challenge	VERB
gs-4062	354	11	to	to	ADP
gs-4062	354	12	disentangle	disentangle	ADJ
gs-4062	354	13	drug	drug	NOUN
gs-4062	354	14	effects	effect	NOUN
gs-4062	354	15	from	from	ADP
gs-4062	354	16	the	the	DET
gs-4062	354	17	background	background	NOUN
gs-4062	354	18	high	high	ADJ
gs-4062	354	19	prevalence	prevalence	NOUN
gs-4062	354	20	of	of	ADP
gs-4062	354	21	mental	mental	ADJ
gs-4062	354	22	health	health	NOUN
gs-4062	354	23	conditions	condition	NOUN
gs-4062	354	24	and	and	CCONJ
gs-4062	354	25	neurocognitive	neurocognitive	ADJ
gs-4062	354	26	impairment	impairment	NOUN
gs-4062	354	27	in	in	ADP
gs-4062	354	28	the	the	DET
gs-4062	354	29	hiv	hiv	NOUN
gs-4062	354	30	-	-	PUNCT
gs-4062	354	31	positive	positive	ADJ
gs-4062	354	32	population	population	NOUN
gs-4062	354	33	.	.	PUNCT
gs-4062	355	1	advanced	advanced	ADJ
gs-4062	355	2	neuroimaging	neuroimaging	NOUN
gs-4062	355	3	results	result	NOUN
gs-4062	355	4	are	be	AUX
gs-4062	355	5	now	now	ADV
gs-4062	355	6	being	be	AUX
gs-4062	355	7	employed	employ	VERB
gs-4062	355	8	to	to	PART
gs-4062	355	9	objectively	objectively	ADV
gs-4062	355	10	measure	measure	VERB
gs-4062	355	11	any	any	DET
gs-4062	355	12	potential	potential	ADJ
gs-4062	355	13	impact	impact	NOUN
gs-4062	355	14	of	of	ADP
gs-4062	355	15	these	these	DET
gs-4062	355	16	drugs	drug	NOUN
gs-4062	355	17	on	on	ADP
gs-4062	355	18	brain	brain	NOUN
gs-4062	355	19	metabolism	metabolism	NOUN
gs-4062	355	20	and	and	CCONJ
gs-4062	355	21	structure	structure	NOUN
gs-4062	355	22	,	,	PUNCT
gs-4062	355	23	adding	add	VERB
gs-4062	355	24	a	a	DET
gs-4062	355	25	new	new	ADJ
gs-4062	355	26	layer	layer	NOUN
gs-4062	355	27	of	of	ADP
gs-4062	355	28	data	datum	NOUN
gs-4062	355	29	to	to	ADP
gs-4062	355	30	this	this	DET
gs-4062	355	31	critical	critical	ADJ
gs-4062	355	32	discussion	discussion	NOUN
gs-4062	355	33	.	.	PUNCT
gs-4062	356	1	the	the	DET
gs-4062	356	2	discussion	discussion	NOUN
gs-4062	356	3	of	of	ADP
gs-4062	356	4	results	result	NOUN
gs-4062	356	5	must	must	AUX
gs-4062	356	6	also	also	ADV
gs-4062	356	7	confront	confront	VERB
gs-4062	356	8	the	the	DET
gs-4062	356	9	stark	stark	ADJ
gs-4062	356	10	reality	reality	NOUN
gs-4062	356	11	of	of	ADP
gs-4062	356	12	access	access	NOUN
gs-4062	356	13	and	and	CCONJ
gs-4062	356	14	equity	equity	NOUN
gs-4062	356	15	.	.	PUNCT
gs-4062	357	1	the	the	DET
gs-4062	357	2	brilliant	brilliant	ADJ
gs-4062	357	3	results	result	NOUN
gs-4062	357	4	of	of	ADP
gs-4062	357	5	modern	modern	ADJ
gs-4062	357	6	clinical	clinical	ADJ
gs-4062	357	7	trials	trial	NOUN
gs-4062	357	8	stand	stand	VERB
gs-4062	357	9	in	in	ADP
gs-4062	357	10	stark	stark	ADJ
gs-4062	357	11	contrast	contrast	NOUN
gs-4062	357	12	to	to	ADP
gs-4062	357	13	the	the	DET
gs-4062	357	14	logistical	logistical	ADJ
gs-4062	357	15	and	and	CCONJ
gs-4062	357	16	financial	financial	ADJ
gs-4062	357	17	results	result	NOUN
gs-4062	357	18	of	of	ADP
gs-4062	357	19	their	their	PRON
gs-4062	357	20	implementation	implementation	NOUN
gs-4062	357	21	on	on	ADP
gs-4062	357	22	a	a	DET
gs-4062	357	23	global	global	ADJ
gs-4062	357	24	scale	scale	NOUN
gs-4062	357	25	.	.	PUNCT
gs-4062	358	1	the	the	DET
gs-4062	358	2	world	world	PROPN
gs-4062	358	3	health	health	PROPN
gs-4062	358	4	organization	organization	NOUN
gs-4062	358	5	's	's	PART
gs-4062	358	6	recommendation	recommendation	NOUN
gs-4062	358	7	of	of	ADP
gs-4062	358	8	dolutegravir	dolutegravir	PROPN
gs-4062	358	9	-	-	PUNCT
gs-4062	358	10	based	base	VERB
gs-4062	358	11	regimens	regimen	NOUN
gs-4062	358	12	was	be	AUX
gs-4062	358	13	a	a	DET
gs-4062	358	14	monumental	monumental	ADJ
gs-4062	358	15	step	step	NOUN
gs-4062	358	16	towards	towards	ADP
gs-4062	358	17	equity	equity	NOUN
gs-4062	358	18	,	,	PUNCT
gs-4062	358	19	yet	yet	CCONJ
gs-4062	358	20	results	result	VERB
gs-4062	358	21	from	from	ADP
gs-4062	358	22	rollout	rollout	NOUN
gs-4062	358	23	programs	program	NOUN
gs-4062	358	24	in	in	ADP
gs-4062	358	25	sub	sub	ADJ
gs-4062	358	26	-	-	ADJ
gs-4062	358	27	saharan	saharan	ADJ
gs-4062	358	28	africa	africa	PROPN
gs-4062	358	29	highlight	highlight	VERB
gs-4062	358	30	persistent	persistent	ADJ
gs-4062	358	31	challenges	challenge	NOUN
gs-4062	358	32	.	.	PUNCT
gs-4062	359	1	these	these	PRON
gs-4062	359	2	include	include	VERB
gs-4062	359	3	drug	drug	NOUN
gs-4062	359	4	stockouts	stockout	NOUN
gs-4062	359	5	,	,	PUNCT
gs-4062	359	6	the	the	DET
gs-4062	359	7	management	management	NOUN
gs-4062	359	8	of	of	ADP
gs-4062	359	9	the	the	DET
gs-4062	359	10	initial	initial	ADJ
gs-4062	359	11	weight	weight	NOUN
gs-4062	359	12	gain	gain	NOUN
gs-4062	359	13	concern	concern	NOUN
gs-4062	359	14	in	in	ADP
gs-4062	359	15	populations	population	NOUN
gs-4062	359	16	with	with	ADP
gs-4062	359	17	high	high	ADJ
gs-4062	359	18	rates	rate	NOUN
gs-4062	359	19	of	of	ADP
gs-4062	359	20	obesity	obesity	NOUN
gs-4062	359	21	and	and	CCONJ
gs-4062	359	22	metabolic	metabolic	NOUN
gs-4062	359	23	disease	disease	NOUN
gs-4062	359	24	,	,	PUNCT
gs-4062	359	25	and	and	CCONJ
gs-4062	359	26	the	the	DET
gs-4062	359	27	navigation	navigation	NOUN
gs-4062	359	28	of	of	ADP
gs-4062	359	29	drug	drug	NOUN
gs-4062	359	30	-	-	PUNCT
gs-4062	359	31	drug	drug	NOUN
gs-4062	359	32	interactions	interaction	NOUN
gs-4062	359	33	with	with	ADP
gs-4062	359	34	common	common	ADJ
gs-4062	359	35	co	co	NOUN
gs-4062	359	36	-	-	NOUN
gs-4062	359	37	medications	medication	NOUN
gs-4062	359	38	for	for	ADP
gs-4062	359	39	tuberculosis	tuberculosis	NOUN
gs-4062	359	40	and	and	CCONJ
gs-4062	359	41	endemic	endemic	ADJ
gs-4062	359	42	diseases	disease	NOUN
gs-4062	359	43	.	.	PUNCT
gs-4062	360	1	the	the	DET
gs-4062	360	2	chasm	chasm	NOUN
gs-4062	360	3	between	between	ADP
gs-4062	360	4	the	the	DET
gs-4062	360	5	availability	availability	NOUN
gs-4062	360	6	of	of	ADP
gs-4062	360	7	cutting	cut	VERB
gs-4062	360	8	-	-	PUNCT
gs-4062	360	9	edge	edge	NOUN
gs-4062	360	10	long	long	ADV
gs-4062	360	11	-	-	PUNCT
gs-4062	360	12	acting	act	VERB
gs-4062	360	13	therapies	therapy	NOUN
gs-4062	360	14	and	and	CCONJ
gs-4062	360	15	novel	novel	ADJ
gs-4062	360	16	agents	agent	NOUN
gs-4062	360	17	in	in	ADP
gs-4062	360	18	high	high	ADJ
gs-4062	360	19	-	-	PUNCT
gs-4062	360	20	income	income	NOUN
gs-4062	360	21	countries	country	NOUN
gs-4062	360	22	versus	versus	ADP
gs-4062	360	23	their	their	PRON
gs-4062	360	24	complete	complete	ADJ
gs-4062	360	25	absence	absence	NOUN
gs-4062	360	26	in	in	ADP
gs-4062	360	27	public	public	ADJ
gs-4062	360	28	health	health	NOUN
gs-4062	360	29	systems	system	NOUN
gs-4062	360	30	in	in	ADP
gs-4062	360	31	low	low	ADJ
gs-4062	360	32	-	-	PUNCT
gs-4062	360	33	income	income	NOUN
gs-4062	360	34	countries	country	NOUN
gs-4062	360	35	is	be	AUX
gs-4062	360	36	perhaps	perhaps	ADV
gs-4062	360	37	the	the	DET
gs-4062	360	38	most	most	ADV
gs-4062	360	39	disappointing	disappointing	ADJ
gs-4062	360	40	result	result	NOUN
gs-4062	360	41	of	of	ADP
gs-4062	360	42	the	the	DET
gs-4062	360	43	modern	modern	ADJ
gs-4062	360	44	antiretroviral	antiretroviral	ADJ
gs-4062	360	45	era	era	NOUN
gs-4062	360	46	.	.	PUNCT
gs-4062	361	1	this	this	DET
gs-4062	361	2	inequity	inequity	NOUN
gs-4062	361	3	fuels	fuel	VERB
gs-4062	361	4	transmission	transmission	NOUN
gs-4062	361	5	chains	chain	NOUN
gs-4062	361	6	and	and	CCONJ
gs-4062	361	7	risks	risk	VERB
gs-4062	361	8	the	the	DET
gs-4062	361	9	development	development	NOUN
gs-4062	361	10	and	and	CCONJ
gs-4062	361	11	global	global	ADJ
gs-4062	361	12	spread	spread	NOUN
gs-4062	361	13	of	of	ADP
gs-4062	361	14	resistance	resistance	NOUN
gs-4062	361	15	,	,	PUNCT
gs-4062	361	16	undermining	undermine	VERB
gs-4062	361	17	progress	progress	NOUN
gs-4062	361	18	for	for	ADP
gs-4062	361	19	all	all	PRON
gs-4062	361	20	.	.	PUNCT
gs-4062	362	1	the	the	DET
gs-4062	362	2	discussion	discussion	NOUN
gs-4062	362	3	must	must	AUX
gs-4062	362	4	,	,	PUNCT
gs-4062	362	5	therefore	therefore	ADV
gs-4062	362	6	,	,	PUNCT
gs-4062	362	7	include	include	VERB
gs-4062	362	8	results	result	NOUN
gs-4062	362	9	from	from	ADP
gs-4062	362	10	initiatives	initiative	NOUN
gs-4062	362	11	like	like	ADP
gs-4062	362	12	the	the	DET
gs-4062	362	13	medicines	medicine	NOUN
gs-4062	362	14	patent	patent	NOUN
gs-4062	362	15	pool	pool	NOUN
gs-4062	362	16	,	,	PUNCT
gs-4062	362	17	which	which	PRON
gs-4062	362	18	negotiate	negotiate	VERB
gs-4062	362	19	voluntary	voluntary	ADJ
gs-4062	362	20	licenses	license	NOUN
gs-4062	362	21	for	for	ADP
gs-4062	362	22	generic	generic	ADJ
gs-4062	362	23	georgian	georgian	NOUN
gs-4062	362	24	scientists/	scientists/	NUM
gs-4062	362	25	.	.	PUNCT
gs-4062	363	1	7	7	NUM
gs-4062	363	2	n	n	PRON
gs-4062	363	3	3	3	NUM
gs-4062	363	4	,	,	PUNCT
gs-4062	363	5	2025	2025	NUM
gs-4062	363	6	538	538	NUM
gs-4062	363	7	manufacture	manufacture	NOUN
gs-4062	363	8	,	,	PUNCT
gs-4062	363	9	and	and	CCONJ
gs-4062	363	10	the	the	DET
gs-4062	363	11	need	need	NOUN
gs-4062	363	12	for	for	ADP
gs-4062	363	13	sustainable	sustainable	ADJ
gs-4062	363	14	international	international	ADJ
gs-4062	363	15	financing	financing	NOUN
gs-4062	363	16	mechanisms	mechanism	NOUN
gs-4062	363	17	to	to	PART
gs-4062	363	18	ensure	ensure	VERB
gs-4062	363	19	that	that	SCONJ
gs-4062	363	20	therapeutic	therapeutic	ADJ
gs-4062	363	21	advances	advance	NOUN
gs-4062	363	22	do	do	AUX
gs-4062	363	23	not	not	PART
gs-4062	363	24	become	become	VERB
gs-4062	363	25	catalysts	catalyst	NOUN
gs-4062	363	26	for	for	ADP
gs-4062	363	27	deeper	deep	ADJ
gs-4062	363	28	health	health	NOUN
gs-4062	363	29	disparities	disparity	NOUN
gs-4062	363	30	.	.	PUNCT
gs-4062	364	1	finally	finally	ADV
gs-4062	364	2	,	,	PUNCT
gs-4062	364	3	the	the	DET
gs-4062	364	4	results	result	NOUN
gs-4062	364	5	of	of	ADP
gs-4062	364	6	basic	basic	ADJ
gs-4062	364	7	science	science	NOUN
gs-4062	364	8	research	research	NOUN
gs-4062	364	9	are	be	AUX
gs-4062	364	10	now	now	ADV
gs-4062	364	11	directly	directly	ADV
gs-4062	364	12	influencing	influence	VERB
gs-4062	364	13	clinical	clinical	ADJ
gs-4062	364	14	development	development	NOUN
gs-4062	364	15	in	in	ADP
gs-4062	364	16	real	real	ADJ
gs-4062	364	17	-	-	PUNCT
gs-4062	364	18	time	time	NOUN
gs-4062	364	19	.	.	PUNCT
gs-4062	365	1	the	the	DET
gs-4062	365	2	application	application	NOUN
gs-4062	365	3	of	of	ADP
gs-4062	365	4	advanced	advanced	ADJ
gs-4062	365	5	technologies	technology	NOUN
gs-4062	365	6	like	like	ADP
gs-4062	365	7	cryo	cryo	NOUN
gs-4062	365	8	-	-	PUNCT
gs-4062	365	9	electron	electron	NOUN
gs-4062	365	10	microscopy	microscopy	NOUN
gs-4062	365	11	has	have	AUX
gs-4062	365	12	yielded	yield	VERB
gs-4062	365	13	atomic	atomic	ADJ
gs-4062	365	14	-	-	PUNCT
gs-4062	365	15	level	level	NOUN
gs-4062	365	16	results	result	NOUN
gs-4062	365	17	of	of	ADP
gs-4062	365	18	drug	drug	NOUN
gs-4062	365	19	-	-	PUNCT
gs-4062	365	20	target	target	NOUN
gs-4062	365	21	interactions	interaction	NOUN
gs-4062	365	22	,	,	PUNCT
gs-4062	365	23	allowing	allow	VERB
gs-4062	365	24	for	for	ADP
gs-4062	365	25	the	the	DET
gs-4062	365	26	rational	rational	ADJ
gs-4062	365	27	design	design	NOUN
gs-4062	365	28	of	of	ADP
gs-4062	365	29	nextgeneration	nextgeneration	NOUN
gs-4062	365	30	inhibitors	inhibitor	NOUN
gs-4062	365	31	that	that	PRON
gs-4062	365	32	are	be	AUX
gs-4062	365	33	pre	pre	ADJ
gs-4062	365	34	-	-	ADJ
gs-4062	365	35	emptively	emptively	ADV
gs-4062	365	36	engineered	engineer	VERB
gs-4062	365	37	to	to	PART
gs-4062	365	38	be	be	AUX
gs-4062	365	39	effective	effective	ADJ
gs-4062	365	40	against	against	ADP
gs-4062	365	41	common	common	ADJ
gs-4062	365	42	resistance	resistance	NOUN
gs-4062	365	43	mutations	mutation	NOUN
gs-4062	365	44	.	.	PUNCT
gs-4062	366	1	for	for	ADP
gs-4062	366	2	example	example	NOUN
gs-4062	366	3	,	,	PUNCT
gs-4062	366	4	the	the	DET
gs-4062	366	5	development	development	NOUN
gs-4062	366	6	of	of	ADP
gs-4062	366	7	novel	novel	ADJ
gs-4062	366	8	nrttis	nrttis	NOUN
gs-4062	366	9	(	(	PUNCT
gs-4062	366	10	nucleotide	nucleotide	NOUN
gs-4062	366	11	reverse	reverse	VERB
gs-4062	366	12	transcriptase	transcriptase	VERB
gs-4062	366	13	translocation	translocation	NOUN
gs-4062	366	14	inhibitors	inhibitor	NOUN
gs-4062	366	15	)	)	PUNCT
gs-4062	366	16	like	like	SCONJ
gs-4062	366	17	islatravir	islatravir	NOUN
gs-4062	366	18	was	be	AUX
gs-4062	366	19	informed	inform	VERB
gs-4062	366	20	by	by	ADP
gs-4062	366	21	a	a	DET
gs-4062	366	22	deep	deep	ADJ
gs-4062	366	23	understanding	understanding	NOUN
gs-4062	366	24	of	of	ADP
gs-4062	366	25	the	the	DET
gs-4062	366	26	structural	structural	ADJ
gs-4062	366	27	limitations	limitation	NOUN
gs-4062	366	28	of	of	ADP
gs-4062	366	29	previous	previous	ADJ
gs-4062	366	30	nrtis	nrtis	PROPN
gs-4062	366	31	.	.	PUNCT
gs-4062	367	1	furthermore	furthermore	ADV
gs-4062	367	2	,	,	PUNCT
gs-4062	367	3	results	result	NOUN
gs-4062	367	4	from	from	ADP
gs-4062	367	5	research	research	NOUN
gs-4062	367	6	into	into	ADP
gs-4062	367	7	the	the	DET
gs-4062	367	8	viral	viral	ADJ
gs-4062	367	9	reservoir	reservoir	NOUN
gs-4062	367	10	are	be	AUX
gs-4062	367	11	identifying	identify	VERB
gs-4062	367	12	new	new	ADJ
gs-4062	367	13	therapeutic	therapeutic	ADJ
gs-4062	367	14	targets	target	NOUN
gs-4062	367	15	beyond	beyond	ADP
gs-4062	367	16	the	the	DET
gs-4062	367	17	virus	virus	NOUN
gs-4062	367	18	itself	itself	PRON
gs-4062	367	19	,	,	PUNCT
gs-4062	367	20	focusing	focus	VERB
gs-4062	367	21	on	on	ADP
gs-4062	367	22	host	host	NOUN
gs-4062	367	23	factors	factor	NOUN
gs-4062	367	24	that	that	PRON
gs-4062	367	25	maintain	maintain	VERB
gs-4062	367	26	latency	latency	NOUN
gs-4062	367	27	.	.	PUNCT
gs-4062	368	1	drugs	drug	NOUN
gs-4062	368	2	that	that	PRON
gs-4062	368	3	modulate	modulate	VERB
gs-4062	368	4	these	these	DET
gs-4062	368	5	pathways	pathway	NOUN
gs-4062	368	6	could	could	AUX
gs-4062	368	7	potentially	potentially	ADV
gs-4062	368	8	be	be	AUX
gs-4062	368	9	used	use	VERB
gs-4062	368	10	to	to	PART
gs-4062	368	11	"	"	PUNCT
gs-4062	368	12	shock	shock	VERB
gs-4062	368	13	"	"	PUNCT
gs-4062	368	14	the	the	DET
gs-4062	368	15	reservoir	reservoir	NOUN
gs-4062	368	16	,	,	PUNCT
gs-4062	368	17	making	make	VERB
gs-4062	368	18	it	it	PRON
gs-4062	368	19	visible	visible	ADJ
gs-4062	368	20	to	to	ADP
gs-4062	368	21	the	the	DET
gs-4062	368	22	immune	immune	ADJ
gs-4062	368	23	system	system	NOUN
gs-4062	368	24	or	or	CCONJ
gs-4062	368	25	susceptible	susceptible	ADJ
gs-4062	368	26	to	to	ADP
gs-4062	368	27	antiviral	antiviral	ADJ
gs-4062	368	28	drugs	drug	NOUN
gs-4062	368	29	,	,	PUNCT
gs-4062	368	30	a	a	DET
gs-4062	368	31	key	key	ADJ
gs-4062	368	32	strategy	strategy	NOUN
gs-4062	368	33	in	in	ADP
gs-4062	368	34	the	the	DET
gs-4062	368	35	pursuit	pursuit	NOUN
gs-4062	368	36	of	of	ADP
gs-4062	368	37	a	a	DET
gs-4062	368	38	cure	cure	NOUN
gs-4062	368	39	.	.	PUNCT
gs-4062	369	1	the	the	DET
gs-4062	369	2	discussion	discussion	NOUN
gs-4062	369	3	is	be	AUX
gs-4062	369	4	now	now	ADV
gs-4062	369	5	moving	move	VERB
gs-4062	369	6	towards	towards	ADP
gs-4062	369	7	how	how	SCONJ
gs-4062	369	8	to	to	PART
gs-4062	369	9	intelligently	intelligently	ADV
gs-4062	369	10	combine	combine	VERB
gs-4062	369	11	these	these	DET
gs-4062	369	12	novel	novel	ADJ
gs-4062	369	13	agents	agent	NOUN
gs-4062	369	14	with	with	ADP
gs-4062	369	15	existing	exist	VERB
gs-4062	369	16	ones	one	NOUN
gs-4062	369	17	to	to	PART
gs-4062	369	18	create	create	VERB
gs-4062	369	19	synergistic	synergistic	ADJ
gs-4062	369	20	,	,	PUNCT
gs-4062	369	21	resistance	resistance	NOUN
gs-4062	369	22	-	-	PUNCT
gs-4062	369	23	proof	proof	NOUN
gs-4062	369	24	,	,	PUNCT
gs-4062	369	25	and	and	CCONJ
gs-4062	369	26	potentially	potentially	ADV
gs-4062	369	27	curative	curative	ADJ
gs-4062	369	28	regimens	regimen	NOUN
gs-4062	369	29	.	.	PUNCT
gs-4062	370	1	in	in	ADP
gs-4062	370	2	synthesizing	synthesize	VERB
gs-4062	370	3	this	this	DET
gs-4062	370	4	vast	vast	ADJ
gs-4062	370	5	and	and	CCONJ
gs-4062	370	6	rapidly	rapidly	ADV
gs-4062	370	7	expanding	expand	VERB
gs-4062	370	8	body	body	NOUN
gs-4062	370	9	of	of	ADP
gs-4062	370	10	results	result	NOUN
gs-4062	370	11	,	,	PUNCT
gs-4062	370	12	the	the	DET
gs-4062	370	13	discussion	discussion	NOUN
gs-4062	370	14	concludes	conclude	VERB
gs-4062	370	15	that	that	SCONJ
gs-4062	370	16	the	the	DET
gs-4062	370	17	field	field	NOUN
gs-4062	370	18	of	of	ADP
gs-4062	370	19	antiretroviral	antiretroviral	ADJ
gs-4062	370	20	therapy	therapy	NOUN
gs-4062	370	21	is	be	AUX
gs-4062	370	22	in	in	ADP
gs-4062	370	23	a	a	DET
gs-4062	370	24	period	period	NOUN
gs-4062	370	25	of	of	ADP
gs-4062	370	26	revolutionary	revolutionary	ADJ
gs-4062	370	27	ferment	ferment	NOUN
gs-4062	370	28	.	.	PUNCT
gs-4062	371	1	the	the	DET
gs-4062	371	2	historical	historical	ADJ
gs-4062	371	3	goals	goal	NOUN
gs-4062	371	4	of	of	ADP
gs-4062	371	5	therapy	therapy	NOUN
gs-4062	371	6	have	have	AUX
gs-4062	371	7	been	be	AUX
gs-4062	371	8	not	not	PART
gs-4062	371	9	just	just	ADV
gs-4062	371	10	met	meet	VERB
gs-4062	371	11	but	but	CCONJ
gs-4062	371	12	exceeded	exceed	VERB
gs-4062	371	13	.	.	PUNCT
gs-4062	372	1	the	the	DET
gs-4062	372	2	current	current	ADJ
gs-4062	372	3	challenge	challenge	NOUN
gs-4062	372	4	is	be	AUX
gs-4062	372	5	no	no	ADV
gs-4062	372	6	longer	long	ADV
gs-4062	372	7	if	if	SCONJ
gs-4062	372	8	we	we	PRON
gs-4062	372	9	can	can	AUX
gs-4062	372	10	suppress	suppress	VERB
gs-4062	372	11	the	the	DET
gs-4062	372	12	virus	virus	NOUN
gs-4062	372	13	,	,	PUNCT
gs-4062	372	14	but	but	CCONJ
gs-4062	372	15	how	how	SCONJ
gs-4062	372	16	we	we	PRON
gs-4062	372	17	can	can	AUX
gs-4062	372	18	do	do	VERB
gs-4062	372	19	it	it	PRON
gs-4062	372	20	in	in	ADP
gs-4062	372	21	a	a	DET
gs-4062	372	22	way	way	NOUN
gs-4062	372	23	that	that	PRON
gs-4062	372	24	optimizes	optimize	VERB
gs-4062	372	25	every	every	DET
gs-4062	372	26	facet	facet	NOUN
gs-4062	372	27	of	of	ADP
gs-4062	372	28	a	a	DET
gs-4062	372	29	person	person	NOUN
gs-4062	372	30	's	's	PART
gs-4062	372	31	life	life	NOUN
gs-4062	372	32	—	—	PUNCT
gs-4062	372	33	physical	physical	ADJ
gs-4062	372	34	,	,	PUNCT
gs-4062	372	35	metabolic	metabolic	NOUN
gs-4062	372	36	,	,	PUNCT
gs-4062	372	37	mental	mental	ADJ
gs-4062	372	38	,	,	PUNCT
gs-4062	372	39	and	and	CCONJ
gs-4062	372	40	social	social	ADJ
gs-4062	372	41	—	—	PUNCT
gs-4062	372	42	over	over	ADP
gs-4062	372	43	a	a	DET
gs-4062	372	44	lifespan	lifespan	NOUN
gs-4062	372	45	that	that	PRON
gs-4062	372	46	now	now	ADV
gs-4062	372	47	approaches	approach	VERB
gs-4062	372	48	that	that	PRON
gs-4062	372	49	of	of	ADP
gs-4062	372	50	the	the	DET
gs-4062	372	51	general	general	ADJ
gs-4062	372	52	population	population	NOUN
gs-4062	372	53	.	.	PUNCT
gs-4062	373	1	the	the	DET
gs-4062	373	2	results	result	NOUN
gs-4062	373	3	point	point	VERB
gs-4062	373	4	towards	towards	ADP
gs-4062	373	5	a	a	DET
gs-4062	373	6	future	future	NOUN
gs-4062	373	7	of	of	ADP
gs-4062	373	8	highly	highly	ADV
gs-4062	373	9	personalized	personalize	VERB
gs-4062	373	10	hiv	hiv	PROPN
gs-4062	373	11	medicine	medicine	NOUN
gs-4062	373	12	,	,	PUNCT
gs-4062	373	13	where	where	SCONJ
gs-4062	373	14	treatment	treatment	NOUN
gs-4062	373	15	choices	choice	NOUN
gs-4062	373	16	are	be	AUX
gs-4062	373	17	tailored	tailor	VERB
gs-4062	373	18	based	base	VERB
gs-4062	373	19	on	on	ADP
gs-4062	373	20	an	an	DET
gs-4062	373	21	individual	individual	NOUN
gs-4062	373	22	's	's	PART
gs-4062	373	23	virus	virus	NOUN
gs-4062	373	24	,	,	PUNCT
gs-4062	373	25	co	co	NOUN
gs-4062	373	26	-	-	NOUN
gs-4062	373	27	morbidities	morbidity	NOUN
gs-4062	373	28	,	,	PUNCT
gs-4062	373	29	genetic	genetic	ADJ
gs-4062	373	30	makeup	makeup	NOUN
gs-4062	373	31	,	,	PUNCT
gs-4062	373	32	and	and	CCONJ
gs-4062	373	33	lifestyle	lifestyle	NOUN
gs-4062	373	34	preferences	preference	NOUN
gs-4062	373	35	,	,	PUNCT
gs-4062	373	36	from	from	ADP
gs-4062	373	37	daily	daily	ADJ
gs-4062	373	38	pills	pill	NOUN
gs-4062	373	39	to	to	ADP
gs-4062	373	40	yearly	yearly	ADJ
gs-4062	373	41	injections	injection	NOUN
gs-4062	373	42	.	.	PUNCT
gs-4062	374	1	these	these	DET
gs-4062	374	2	extraordinary	extraordinary	ADJ
gs-4062	374	3	results	result	NOUN
gs-4062	374	4	are	be	AUX
gs-4062	374	5	a	a	DET
gs-4062	374	6	powerful	powerful	ADJ
gs-4062	374	7	testament	testament	NOUN
gs-4062	374	8	to	to	ADP
gs-4062	374	9	scientific	scientific	ADJ
gs-4062	374	10	innovation	innovation	NOUN
gs-4062	374	11	but	but	CCONJ
gs-4062	374	12	also	also	ADV
gs-4062	374	13	serve	serve	VERB
gs-4062	374	14	as	as	ADP
gs-4062	374	15	a	a	DET
gs-4062	374	16	urgent	urgent	ADJ
gs-4062	374	17	reminder	reminder	NOUN
gs-4062	374	18	that	that	SCONJ
gs-4062	374	19	the	the	DET
gs-4062	374	20	ultimate	ultimate	ADJ
gs-4062	374	21	result	result	NOUN
gs-4062	374	22	—	—	PUNCT
gs-4062	374	23	health	health	NOUN
gs-4062	374	24	for	for	ADP
gs-4062	374	25	all	all	PRON
gs-4062	374	26	—	—	PUNCT
gs-4062	374	27	remains	remain	VERB
gs-4062	374	28	an	an	DET
gs-4062	374	29	unfinished	unfinished	ADJ
gs-4062	374	30	goal	goal	NOUN
gs-4062	374	31	demanding	demand	VERB
gs-4062	374	32	relentless	relentless	ADJ
gs-4062	374	33	advocacy	advocacy	NOUN
gs-4062	374	34	,	,	PUNCT
gs-4062	374	35	global	global	ADJ
gs-4062	374	36	solidarity	solidarity	NOUN
gs-4062	374	37	,	,	PUNCT
gs-4062	374	38	and	and	CCONJ
gs-4062	374	39	scientific	scientific	ADJ
gs-4062	374	40	perseverance	perseverance	NOUN
gs-4062	374	41	.	.	PUNCT
gs-4062	375	1	the	the	DET
gs-4062	375	2	evolution	evolution	NOUN
gs-4062	375	3	of	of	ADP
gs-4062	375	4	hiv	hiv	PROPN
gs-4062	375	5	therapy	therapy	NOUN
gs-4062	375	6	and	and	CCONJ
gs-4062	375	7	the	the	DET
gs-4062	375	8	imperative	imperative	NOUN
gs-4062	375	9	for	for	ADP
gs-4062	375	10	innovation	innovation	NOUN
gs-4062	375	11	the	the	DET
gs-4062	375	12	management	management	NOUN
gs-4062	375	13	of	of	ADP
gs-4062	375	14	human	human	ADJ
gs-4062	375	15	immunodeficiency	immunodeficiency	NOUN
gs-4062	375	16	virus	virus	NOUN
gs-4062	375	17	(	(	PUNCT
gs-4062	375	18	hiv	hiv	NOUN
gs-4062	375	19	)	)	PUNCT
gs-4062	375	20	infection	infection	NOUN
gs-4062	375	21	represents	represent	VERB
gs-4062	375	22	one	one	NUM
gs-4062	375	23	of	of	ADP
gs-4062	375	24	the	the	DET
gs-4062	375	25	most	most	ADV
gs-4062	375	26	remarkable	remarkable	ADJ
gs-4062	375	27	success	success	NOUN
gs-4062	375	28	stories	story	NOUN
gs-4062	375	29	in	in	ADP
gs-4062	375	30	modern	modern	ADJ
gs-4062	375	31	medicine	medicine	NOUN
gs-4062	375	32	.	.	PUNCT
gs-4062	376	1	from	from	ADP
gs-4062	376	2	a	a	DET
gs-4062	376	3	certain	certain	ADJ
gs-4062	376	4	fatal	fatal	ADJ
gs-4062	376	5	diagnosis	diagnosis	NOUN
gs-4062	376	6	in	in	ADP
gs-4062	376	7	the	the	DET
gs-4062	376	8	1980s	1980	NOUN
gs-4062	376	9	,	,	PUNCT
gs-4062	376	10	hiv	hiv	PROPN
gs-4062	376	11	has	have	AUX
gs-4062	376	12	been	be	AUX
gs-4062	376	13	transformed	transform	VERB
gs-4062	376	14	into	into	ADP
gs-4062	376	15	a	a	DET
gs-4062	376	16	chronic	chronic	NOUN
gs-4062	376	17	,	,	PUNCT
gs-4062	376	18	manageable	manageable	ADJ
gs-4062	376	19	condition	condition	NOUN
gs-4062	376	20	,	,	PUNCT
gs-4062	376	21	primarily	primarily	ADV
gs-4062	376	22	due	due	ADP
gs-4062	376	23	to	to	ADP
gs-4062	376	24	the	the	DET
gs-4062	376	25	development	development	NOUN
gs-4062	376	26	and	and	CCONJ
gs-4062	376	27	continuous	continuous	ADJ
gs-4062	376	28	refinement	refinement	NOUN
gs-4062	376	29	of	of	ADP
gs-4062	376	30	antiretroviral	antiretroviral	ADJ
gs-4062	376	31	therapy	therapy	NOUN
gs-4062	376	32	(	(	PUNCT
gs-4062	376	33	art	art	NOUN
gs-4062	376	34	)	)	PUNCT
gs-4062	376	35	.	.	PUNCT
gs-4062	377	1	the	the	DET
gs-4062	377	2	foundational	foundational	ADJ
gs-4062	377	3	breakthrough	breakthrough	NOUN
gs-4062	377	4	came	come	VERB
gs-4062	377	5	with	with	ADP
gs-4062	377	6	the	the	DET
gs-4062	377	7	introduction	introduction	NOUN
gs-4062	377	8	of	of	ADP
gs-4062	377	9	combination	combination	NOUN
gs-4062	377	10	art	art	NOUN
gs-4062	377	11	(	(	PUNCT
gs-4062	377	12	cart	cart	NOUN
gs-4062	377	13	)	)	PUNCT
gs-4062	377	14	,	,	PUNCT
gs-4062	377	15	often	often	ADV
gs-4062	377	16	colloquially	colloquially	ADV
gs-4062	377	17	known	know	VERB
gs-4062	377	18	as	as	ADP
gs-4062	377	19	highly	highly	ADV
gs-4062	377	20	active	active	ADJ
gs-4062	377	21	art	art	NOUN
gs-4062	377	22	(	(	PUNCT
gs-4062	377	23	haart	haart	PROPN
gs-4062	377	24	)	)	PUNCT
gs-4062	377	25	,	,	PUNCT
gs-4062	377	26	in	in	ADP
gs-4062	377	27	the	the	DET
gs-4062	377	28	mid-1990s	mid-1990	NOUN
gs-4062	377	29	.	.	PUNCT
gs-4062	378	1	this	this	DET
gs-4062	378	2	strategy	strategy	NOUN
gs-4062	378	3	,	,	PUNCT
gs-4062	378	4	which	which	PRON
gs-4062	378	5	involves	involve	VERB
gs-4062	378	6	the	the	DET
gs-4062	378	7	simultaneous	simultaneous	ADJ
gs-4062	378	8	use	use	NOUN
gs-4062	378	9	of	of	ADP
gs-4062	378	10	multiple	multiple	ADJ
gs-4062	378	11	drugs	drug	NOUN
gs-4062	378	12	targeting	target	VERB
gs-4062	378	13	different	different	ADJ
gs-4062	378	14	stages	stage	NOUN
gs-4062	378	15	of	of	ADP
gs-4062	378	16	the	the	DET
gs-4062	378	17	hiv	hiv	PROPN
gs-4062	378	18	lifecycle	lifecycle	NOUN
gs-4062	378	19	,	,	PUNCT
gs-4062	378	20	successfully	successfully	ADV
gs-4062	378	21	suppressed	suppress	VERB
gs-4062	378	22	viral	viral	ADJ
gs-4062	378	23	replication	replication	NOUN
gs-4062	378	24	,	,	PUNCT
gs-4062	378	25	restored	restore	VERB
gs-4062	378	26	immune	immune	ADJ
gs-4062	378	27	function	function	NOUN
gs-4062	378	28	,	,	PUNCT
gs-4062	378	29	and	and	CCONJ
gs-4062	378	30	dramatically	dramatically	ADV
gs-4062	378	31	reduced	reduce	VERB
gs-4062	378	32	hiv	hiv	PROPN
gs-4062	378	33	-	-	PUNCT
gs-4062	378	34	related	relate	VERB
gs-4062	378	35	morbidity	morbidity	NOUN
gs-4062	378	36	and	and	CCONJ
gs-4062	378	37	mortality	mortality	NOUN
gs-4062	378	38	.	.	PUNCT
gs-4062	379	1	however	however	ADV
gs-4062	379	2	,	,	PUNCT
gs-4062	379	3	the	the	DET
gs-4062	379	4	early	early	ADJ
gs-4062	379	5	eras	era	NOUN
gs-4062	379	6	of	of	ADP
gs-4062	379	7	art	art	NOUN
gs-4062	379	8	were	be	AUX
gs-4062	379	9	fraught	fraught	ADJ
gs-4062	379	10	with	with	ADP
gs-4062	379	11	significant	significant	ADJ
gs-4062	379	12	challenges	challenge	NOUN
gs-4062	379	13	.	.	PUNCT
gs-4062	380	1	regimens	regimen	NOUN
gs-4062	380	2	were	be	AUX
gs-4062	380	3	characterized	characterize	VERB
gs-4062	380	4	by	by	ADP
gs-4062	380	5	a	a	DET
gs-4062	380	6	high	high	ADJ
gs-4062	380	7	pill	pill	NOUN
gs-4062	380	8	burden	burden	NOUN
gs-4062	380	9	,	,	PUNCT
gs-4062	380	10	complex	complex	ADJ
gs-4062	380	11	dosing	dosing	NOUN
gs-4062	380	12	schedules	schedule	NOUN
gs-4062	380	13	,	,	PUNCT
gs-4062	380	14	severe	severe	ADJ
gs-4062	380	15	shortand	shortand	NOUN
gs-4062	380	16	long	long	ADJ
gs-4062	380	17	-	-	PUNCT
gs-4062	380	18	term	term	NOUN
gs-4062	380	19	toxicities	toxicity	NOUN
gs-4062	380	20	,	,	PUNCT
gs-4062	380	21	and	and	CCONJ
gs-4062	380	22	significant	significant	ADJ
gs-4062	380	23	drug	drug	NOUN
gs-4062	380	24	-	-	PUNCT
gs-4062	380	25	drug	drug	NOUN
gs-4062	380	26	interactions	interaction	NOUN
gs-4062	380	27	.	.	PUNCT
gs-4062	381	1	furthermore	furthermore	ADV
gs-4062	381	2	,	,	PUNCT
gs-4062	381	3	the	the	DET
gs-4062	381	4	high	high	ADJ
gs-4062	381	5	rate	rate	NOUN
gs-4062	381	6	of	of	ADP
gs-4062	381	7	viral	viral	ADJ
gs-4062	381	8	mutation	mutation	NOUN
gs-4062	381	9	,	,	PUNCT
gs-4062	381	10	combined	combine	VERB
gs-4062	381	11	with	with	ADP
gs-4062	381	12	suboptimal	suboptimal	ADJ
gs-4062	381	13	adherence	adherence	NOUN
gs-4062	381	14	driven	drive	VERB
gs-4062	381	15	by	by	ADP
gs-4062	381	16	these	these	DET
gs-4062	381	17	difficult	difficult	ADJ
gs-4062	381	18	regimens	regimen	NOUN
gs-4062	381	19	,	,	PUNCT
gs-4062	381	20	led	lead	VERB
gs-4062	381	21	to	to	ADP
gs-4062	381	22	the	the	DET
gs-4062	381	23	emergence	emergence	NOUN
gs-4062	381	24	of	of	ADP
gs-4062	381	25	drug	drug	NOUN
gs-4062	381	26	-	-	PUNCT
gs-4062	381	27	resistant	resistant	ADJ
gs-4062	381	28	viral	viral	ADJ
gs-4062	381	29	strains	strain	NOUN
gs-4062	381	30	,	,	PUNCT
gs-4062	381	31	threatening	threaten	VERB
gs-4062	381	32	the	the	DET
gs-4062	381	33	long	long	ADJ
gs-4062	381	34	-	-	PUNCT
gs-4062	381	35	term	term	NOUN
gs-4062	381	36	efficacy	efficacy	NOUN
gs-4062	381	37	of	of	ADP
gs-4062	381	38	available	available	ADJ
gs-4062	381	39	treatments	treatment	NOUN
gs-4062	381	40	.	.	PUNCT
gs-4062	382	1	these	these	DET
gs-4062	382	2	limitations	limitation	NOUN
gs-4062	382	3	underscored	underscore	VERB
gs-4062	382	4	a	a	DET
gs-4062	382	5	persistent	persistent	ADJ
gs-4062	382	6	and	and	CCONJ
gs-4062	382	7	urgent	urgent	ADJ
gs-4062	382	8	need	need	NOUN
gs-4062	382	9	for	for	ADP
gs-4062	382	10	innovation	innovation	NOUN
gs-4062	382	11	—	—	PUNCT
gs-4062	382	12	the	the	DET
gs-4062	382	13	development	development	NOUN
gs-4062	382	14	of	of	ADP
gs-4062	382	15	new	new	ADJ
gs-4062	382	16	antiretroviral	antiretroviral	ADJ
gs-4062	382	17	agents	agent	NOUN
gs-4062	382	18	that	that	PRON
gs-4062	382	19	were	be	AUX
gs-4062	382	20	more	more	ADV
gs-4062	382	21	potent	potent	ADJ
gs-4062	382	22	,	,	PUNCT
gs-4062	382	23	more	more	ADV
gs-4062	382	24	durable	durable	ADJ
gs-4062	382	25	against	against	ADP
gs-4062	382	26	resistance	resistance	NOUN
gs-4062	382	27	,	,	PUNCT
gs-4062	382	28	safer	safe	ADJ
gs-4062	382	29	,	,	PUNCT
gs-4062	382	30	and	and	CCONJ
gs-4062	382	31	more	more	ADV
gs-4062	382	32	patient	patient	NOUN
gs-4062	382	33	-	-	PUNCT
gs-4062	382	34	friendly	friendly	ADJ
gs-4062	382	35	.	.	PUNCT
gs-4062	383	1	georgian	georgian	NOUN
gs-4062	383	2	scientists/	scientists/	NUM
gs-4062	383	3	.	.	PUNCT
gs-4062	384	1	7	7	NUM
gs-4062	384	2	n	n	PRON
gs-4062	384	3	3	3	NUM
gs-4062	384	4	,	,	PUNCT
gs-4062	384	5	2025	2025	NUM
gs-4062	384	6	539	539	NUM
gs-4062	384	7	the	the	DET
gs-4062	384	8	scientific	scientific	ADJ
gs-4062	384	9	discussion	discussion	NOUN
gs-4062	384	10	around	around	ADP
gs-4062	384	11	antiretroviral	antiretroviral	ADJ
gs-4062	384	12	drugs	drug	NOUN
gs-4062	384	13	is	be	AUX
gs-4062	384	14	,	,	PUNCT
gs-4062	384	15	therefore	therefore	ADV
gs-4062	384	16	,	,	PUNCT
gs-4062	384	17	not	not	PART
gs-4062	384	18	static	static	ADJ
gs-4062	384	19	;	;	PUNCT
gs-4062	384	20	it	it	PRON
gs-4062	384	21	is	be	AUX
gs-4062	384	22	a	a	DET
gs-4062	384	23	dynamic	dynamic	ADJ
gs-4062	384	24	and	and	CCONJ
gs-4062	384	25	ever	ever	ADV
gs-4062	384	26	-	-	PUNCT
gs-4062	384	27	evolving	evolve	VERB
gs-4062	384	28	discourse	discourse	NOUN
gs-4062	384	29	manifested	manifest	VERB
gs-4062	384	30	in	in	ADP
gs-4062	384	31	continuous	continuous	ADJ
gs-4062	384	32	clinical	clinical	ADJ
gs-4062	384	33	trials	trial	NOUN
gs-4062	384	34	,	,	PUNCT
gs-4062	384	35	updated	update	VERB
gs-4062	384	36	treatment	treatment	NOUN
gs-4062	384	37	guidelines	guideline	NOUN
gs-4062	384	38	,	,	PUNCT
gs-4062	384	39	pharmacovigilance	pharmacovigilance	NOUN
gs-4062	384	40	reports	report	NOUN
gs-4062	384	41	,	,	PUNCT
gs-4062	384	42	and	and	CCONJ
gs-4062	384	43	real	real	ADJ
gs-4062	384	44	-	-	PUNCT
gs-4062	384	45	world	world	NOUN
gs-4062	384	46	evidence	evidence	NOUN
gs-4062	384	47	studies	study	NOUN
gs-4062	384	48	.	.	PUNCT
gs-4062	385	1	this	this	DET
gs-4062	385	2	discourse	discourse	NOUN
gs-4062	385	3	focuses	focus	VERB
gs-4062	385	4	on	on	ADP
gs-4062	385	5	several	several	ADJ
gs-4062	385	6	key	key	ADJ
gs-4062	385	7	pillars	pillar	NOUN
gs-4062	385	8	:	:	PUNCT
gs-4062	385	9	the	the	DET
gs-4062	385	10	precise	precise	ADJ
gs-4062	385	11	classification	classification	NOUN
gs-4062	385	12	of	of	ADP
gs-4062	385	13	drugs	drug	NOUN
gs-4062	385	14	based	base	VERB
gs-4062	385	15	on	on	ADP
gs-4062	385	16	their	their	PRON
gs-4062	385	17	molecular	molecular	ADJ
gs-4062	385	18	targets	target	NOUN
gs-4062	385	19	;	;	PUNCT
gs-4062	385	20	their	their	PRON
gs-4062	385	21	mechanisms	mechanism	NOUN
gs-4062	385	22	of	of	ADP
gs-4062	385	23	action	action	NOUN
gs-4062	385	24	at	at	ADP
gs-4062	385	25	the	the	DET
gs-4062	385	26	biochemical	biochemical	ADJ
gs-4062	385	27	level	level	NOUN
gs-4062	385	28	;	;	PUNCT
gs-4062	385	29	their	their	PRON
gs-4062	385	30	pharmacological	pharmacological	ADJ
gs-4062	385	31	properties	property	NOUN
gs-4062	385	32	,	,	PUNCT
gs-4062	385	33	including	include	VERB
gs-4062	385	34	pharmacokinetics	pharmacokinetic	NOUN
gs-4062	385	35	and	and	CCONJ
gs-4062	385	36	pharmacodynamics	pharmacodynamic	NOUN
gs-4062	385	37	;	;	PUNCT
gs-4062	385	38	their	their	PRON
gs-4062	385	39	integration	integration	NOUN
gs-4062	385	40	into	into	ADP
gs-4062	385	41	clinical	clinical	ADJ
gs-4062	385	42	use	use	NOUN
gs-4062	385	43	through	through	ADP
gs-4062	385	44	evidence	evidence	NOUN
gs-4062	385	45	-	-	PUNCT
gs-4062	385	46	based	base	VERB
gs-4062	385	47	guidelines	guideline	NOUN
gs-4062	385	48	;	;	PUNCT
gs-4062	385	49	their	their	PRON
gs-4062	385	50	unique	unique	ADJ
gs-4062	385	51	features	feature	NOUN
gs-4062	385	52	and	and	CCONJ
gs-4062	385	53	advantages	advantage	NOUN
gs-4062	385	54	over	over	ADP
gs-4062	385	55	previous	previous	ADJ
gs-4062	385	56	generations	generation	NOUN
gs-4062	385	57	;	;	PUNCT
gs-4062	385	58	and	and	CCONJ
gs-4062	385	59	a	a	DET
gs-4062	385	60	critical	critical	ADJ
gs-4062	385	61	analysis	analysis	NOUN
gs-4062	385	62	of	of	ADP
gs-4062	385	63	their	their	PRON
gs-4062	385	64	toxicities	toxicity	NOUN
gs-4062	385	65	and	and	CCONJ
gs-4062	385	66	safety	safety	NOUN
gs-4062	385	67	profiles	profile	NOUN
gs-4062	385	68	.	.	PUNCT
gs-4062	386	1	this	this	DET
gs-4062	386	2	comprehensive	comprehensive	ADJ
gs-4062	386	3	analysis	analysis	NOUN
gs-4062	386	4	aims	aim	VERB
gs-4062	386	5	to	to	PART
gs-4062	386	6	synthesize	synthesize	VERB
gs-4062	386	7	this	this	DET
gs-4062	386	8	vast	vast	ADJ
gs-4062	386	9	scientific	scientific	ADJ
gs-4062	386	10	discussion	discussion	NOUN
gs-4062	386	11	,	,	PUNCT
gs-4062	386	12	providing	provide	VERB
gs-4062	386	13	a	a	DET
gs-4062	386	14	detailed	detailed	ADJ
gs-4062	386	15	overview	overview	NOUN
gs-4062	386	16	of	of	ADP
gs-4062	386	17	the	the	DET
gs-4062	386	18	current	current	ADJ
gs-4062	386	19	landscape	landscape	NOUN
gs-4062	386	20	of	of	ADP
gs-4062	386	21	new	new	ADJ
gs-4062	386	22	antiretroviral	antiretroviral	ADJ
gs-4062	386	23	medicines	medicine	NOUN
gs-4062	386	24	.	.	PUNCT
gs-4062	387	1	it	it	PRON
gs-4062	387	2	will	will	AUX
gs-4062	387	3	delve	delve	VERB
gs-4062	387	4	into	into	ADP
gs-4062	387	5	the	the	DET
gs-4062	387	6	latest	late	ADJ
gs-4062	387	7	drug	drug	NOUN
gs-4062	387	8	classes	class	NOUN
gs-4062	387	9	,	,	PUNCT
gs-4062	387	10	such	such	ADJ
gs-4062	387	11	as	as	ADP
gs-4062	387	12	integrase	integrase	NOUN
gs-4062	387	13	strand	strand	NOUN
gs-4062	387	14	transfer	transfer	NOUN
gs-4062	387	15	inhibitors	inhibitor	NOUN
gs-4062	387	16	(	(	PUNCT
gs-4062	387	17	instis	instis	NOUN
gs-4062	387	18	)	)	PUNCT
gs-4062	387	19	and	and	CCONJ
gs-4062	387	20	novel	novel	ADJ
gs-4062	387	21	attachment	attachment	NOUN
gs-4062	387	22	and	and	CCONJ
gs-4062	387	23	post	post	ADJ
gs-4062	387	24	-	-	ADJ
gs-4062	387	25	attachment	attachment	ADJ
gs-4062	387	26	inhibitors	inhibitor	NOUN
gs-4062	387	27	,	,	PUNCT
gs-4062	387	28	while	while	SCONJ
gs-4062	387	29	also	also	ADV
gs-4062	387	30	exploring	explore	VERB
gs-4062	387	31	significant	significant	ADJ
gs-4062	387	32	advancements	advancement	NOUN
gs-4062	387	33	within	within	ADP
gs-4062	387	34	older	old	ADJ
gs-4062	387	35	classes	class	NOUN
gs-4062	387	36	,	,	PUNCT
gs-4062	387	37	such	such	ADJ
gs-4062	387	38	as	as	ADP
gs-4062	387	39	the	the	DET
gs-4062	387	40	development	development	NOUN
gs-4062	387	41	of	of	ADP
gs-4062	387	42	tenofovir	tenofovir	PROPN
gs-4062	387	43	alafenamide	alafenamide	PROPN
gs-4062	387	44	(	(	PUNCT
gs-4062	387	45	taf	taf	NOUN
gs-4062	387	46	)	)	PUNCT
gs-4062	387	47	.	.	PUNCT
gs-4062	388	1	furthermore	furthermore	ADV
gs-4062	388	2	,	,	PUNCT
gs-4062	388	3	it	it	PRON
gs-4062	388	4	will	will	AUX
gs-4062	388	5	analyze	analyze	VERB
gs-4062	388	6	the	the	DET
gs-4062	388	7	paradigm	paradigm	NOUN
gs-4062	388	8	shift	shift	NOUN
gs-4062	388	9	towards	towards	ADP
gs-4062	388	10	long	long	ADV
gs-4062	388	11	-	-	PUNCT
gs-4062	388	12	acting	act	VERB
gs-4062	388	13	injectable	injectable	ADJ
gs-4062	388	14	formulations	formulation	NOUN
gs-4062	388	15	and	and	CCONJ
gs-4062	388	16	the	the	DET
gs-4062	388	17	ongoing	ongoing	ADJ
gs-4062	388	18	pursuit	pursuit	NOUN
gs-4062	388	19	of	of	ADP
gs-4062	388	20	strategies	strategy	NOUN
gs-4062	388	21	for	for	ADP
gs-4062	388	22	managing	manage	VERB
gs-4062	388	23	multidrug	multidrug	NOUN
gs-4062	388	24	-	-	PUNCT
gs-4062	388	25	resistant	resistant	ADJ
gs-4062	388	26	hiv	hiv	NOUN
gs-4062	388	27	.	.	PUNCT
gs-4062	389	1	by	by	ADP
gs-4062	389	2	examining	examine	VERB
gs-4062	389	3	the	the	DET
gs-4062	389	4	classification	classification	NOUN
gs-4062	389	5	,	,	PUNCT
gs-4062	389	6	mechanisms	mechanism	NOUN
gs-4062	389	7	,	,	PUNCT
gs-4062	389	8	pharmacology	pharmacology	NOUN
gs-4062	389	9	,	,	PUNCT
gs-4062	389	10	clinical	clinical	ADJ
gs-4062	389	11	utility	utility	NOUN
gs-4062	389	12	,	,	PUNCT
gs-4062	389	13	and	and	CCONJ
gs-4062	389	14	toxicities	toxicity	NOUN
gs-4062	389	15	of	of	ADP
gs-4062	389	16	these	these	DET
gs-4062	389	17	agents	agent	NOUN
gs-4062	389	18	,	,	PUNCT
gs-4062	389	19	this	this	DET
gs-4062	389	20	review	review	NOUN
gs-4062	389	21	encapsulates	encapsulate	VERB
gs-4062	389	22	the	the	DET
gs-4062	389	23	current	current	ADJ
gs-4062	389	24	state	state	NOUN
gs-4062	389	25	of	of	ADP
gs-4062	389	26	art	art	NOUN
gs-4062	389	27	and	and	CCONJ
gs-4062	389	28	the	the	DET
gs-4062	389	29	future	future	ADJ
gs-4062	389	30	directions	direction	NOUN
gs-4062	389	31	of	of	ADP
gs-4062	389	32	hiv	hiv	PROPN
gs-4062	389	33	therapeutics	therapeutic	NOUN
gs-4062	389	34	.	.	PUNCT
gs-4062	390	1	classification	classification	NOUN
gs-4062	390	2	of	of	ADP
gs-4062	390	3	antiretroviral	antiretroviral	ADJ
gs-4062	390	4	agents	agent	NOUN
gs-4062	390	5	:	:	PUNCT
gs-4062	390	6	from	from	ADP
gs-4062	390	7	foundational	foundational	ADJ
gs-4062	390	8	pillars	pillar	NOUN
gs-4062	390	9	to	to	ADP
gs-4062	390	10	novel	novel	ADJ
gs-4062	390	11	mechanisms	mechanism	NOUN
gs-4062	390	12	antiretroviral	antiretroviral	ADJ
gs-4062	390	13	drugs	drug	NOUN
gs-4062	390	14	are	be	AUX
gs-4062	390	15	systematically	systematically	ADV
gs-4062	390	16	classified	classify	VERB
gs-4062	390	17	based	base	VERB
gs-4062	390	18	on	on	ADP
gs-4062	390	19	their	their	PRON
gs-4062	390	20	specific	specific	ADJ
gs-4062	390	21	molecular	molecular	ADJ
gs-4062	390	22	target	target	NOUN
gs-4062	390	23	within	within	ADP
gs-4062	390	24	the	the	DET
gs-4062	390	25	hiv	hiv	PROPN
gs-4062	390	26	replication	replication	NOUN
gs-4062	390	27	cycle	cycle	NOUN
gs-4062	390	28	.	.	PUNCT
gs-4062	391	1	this	this	DET
gs-4062	391	2	classification	classification	NOUN
gs-4062	391	3	is	be	AUX
gs-4062	391	4	crucial	crucial	ADJ
gs-4062	391	5	for	for	ADP
gs-4062	391	6	understanding	understand	VERB
gs-4062	391	7	drug	drug	NOUN
gs-4062	391	8	interactions	interaction	NOUN
gs-4062	391	9	,	,	PUNCT
gs-4062	391	10	constructing	construct	VERB
gs-4062	391	11	synergistic	synergistic	ADJ
gs-4062	391	12	regimens	regimen	NOUN
gs-4062	391	13	,	,	PUNCT
gs-4062	391	14	and	and	CCONJ
gs-4062	391	15	managing	manage	VERB
gs-4062	391	16	cross	cross	NOUN
gs-4062	391	17	-	-	NOUN
gs-4062	391	18	resistance	resistance	NOUN
gs-4062	391	19	.	.	PUNCT
gs-4062	392	1	the	the	DET
gs-4062	392	2	traditional	traditional	ADJ
gs-4062	392	3	backbone	backbone	NOUN
gs-4062	392	4	of	of	ADP
gs-4062	392	5	art	art	NOUN
gs-4062	392	6	has	have	AUX
gs-4062	392	7	consisted	consist	VERB
gs-4062	392	8	of	of	ADP
gs-4062	392	9	three	three	NUM
gs-4062	392	10	core	core	ADJ
gs-4062	392	11	classes	class	NOUN
gs-4062	392	12	,	,	PUNCT
gs-4062	392	13	now	now	ADV
gs-4062	392	14	joined	join	VERB
gs-4062	392	15	by	by	ADP
gs-4062	392	16	newer	new	ADJ
gs-4062	392	17	,	,	PUNCT
gs-4062	392	18	highly	highly	ADV
gs-4062	392	19	effective	effective	ADJ
gs-4062	392	20	classes	class	NOUN
gs-4062	392	21	and	and	CCONJ
gs-4062	392	22	entry	entry	NOUN
gs-4062	392	23	inhibitors	inhibitor	NOUN
gs-4062	392	24	.	.	PUNCT
gs-4062	393	1	nucleoside	nucleoside	NOUN
gs-4062	393	2	/	/	SYM
gs-4062	393	3	nucleotide	nucleotide	NOUN
gs-4062	393	4	reverse	reverse	NOUN
gs-4062	393	5	transcriptase	transcriptase	NOUN
gs-4062	393	6	inhibitors	inhibitor	NOUN
gs-4062	393	7	(	(	PUNCT
gs-4062	393	8	nrtis	nrtis	PROPN
gs-4062	393	9	):	):	PUNCT
gs-4062	393	10	nrtis	nrtis	PROPN
gs-4062	393	11	were	be	AUX
gs-4062	393	12	the	the	DET
gs-4062	393	13	first	first	ADJ
gs-4062	393	14	class	class	NOUN
gs-4062	393	15	of	of	ADP
gs-4062	393	16	drugs	drug	NOUN
gs-4062	393	17	approved	approve	VERB
gs-4062	393	18	to	to	PART
gs-4062	393	19	treat	treat	VERB
gs-4062	393	20	hiv	hiv	PROPN
gs-4062	393	21	infection	infection	NOUN
gs-4062	393	22	.	.	PUNCT
gs-4062	394	1	they	they	PRON
gs-4062	394	2	are	be	AUX
gs-4062	394	3	prodrugs	prodrug	NOUN
gs-4062	394	4	that	that	PRON
gs-4062	394	5	require	require	VERB
gs-4062	394	6	intracellular	intracellular	ADJ
gs-4062	394	7	phosphorylation	phosphorylation	NOUN
gs-4062	394	8	to	to	PART
gs-4062	394	9	become	become	VERB
gs-4062	394	10	active	active	ADJ
gs-4062	394	11	.	.	PUNCT
gs-4062	395	1	the	the	DET
gs-4062	395	2	active	active	ADJ
gs-4062	395	3	form	form	NOUN
gs-4062	395	4	mimics	mimic	VERB
gs-4062	395	5	the	the	DET
gs-4062	395	6	natural	natural	ADJ
gs-4062	395	7	deoxynucleoside	deoxynucleoside	NOUN
gs-4062	395	8	triphosphates	triphosphate	NOUN
gs-4062	395	9	(	(	PUNCT
gs-4062	395	10	dntps	dntps	PROPN
gs-4062	395	11	)	)	PUNCT
gs-4062	395	12	that	that	PRON
gs-4062	395	13	hiv	hiv	PROPN
gs-4062	395	14	reverse	reverse	VERB
gs-4062	395	15	transcriptase	transcriptase	NOUN
gs-4062	395	16	uses	use	VERB
gs-4062	395	17	to	to	PART
gs-4062	395	18	synthesize	synthesize	VERB
gs-4062	395	19	viral	viral	ADJ
gs-4062	395	20	dna	dna	NOUN
gs-4062	395	21	.	.	PUNCT
gs-4062	396	1	when	when	SCONJ
gs-4062	396	2	incorporated	incorporate	VERB
gs-4062	396	3	into	into	ADP
gs-4062	396	4	the	the	DET
gs-4062	396	5	growing	grow	VERB
gs-4062	396	6	dna	dna	NOUN
gs-4062	396	7	chain	chain	NOUN
gs-4062	396	8	,	,	PUNCT
gs-4062	396	9	they	they	PRON
gs-4062	396	10	act	act	VERB
gs-4062	396	11	as	as	ADP
gs-4062	396	12	chain	chain	NOUN
gs-4062	396	13	terminators	terminator	NOUN
gs-4062	396	14	,	,	PUNCT
gs-4062	396	15	halting	halt	VERB
gs-4062	396	16	dna	dna	ADJ
gs-4062	396	17	synthesis	synthesis	NOUN
gs-4062	396	18	and	and	CCONJ
gs-4062	396	19	aborting	abort	VERB
gs-4062	396	20	viral	viral	ADJ
gs-4062	396	21	replication	replication	NOUN
gs-4062	396	22	.	.	PUNCT
gs-4062	397	1	key	key	ADJ
gs-4062	397	2	agents	agent	NOUN
gs-4062	397	3	:	:	PUNCT
gs-4062	397	4	zidovudine	zidovudine	PROPN
gs-4062	397	5	(	(	PUNCT
gs-4062	397	6	azt	azt	PROPN
gs-4062	397	7	)	)	PUNCT
gs-4062	397	8	,	,	PUNCT
gs-4062	397	9	didanosine	didanosine	PROPN
gs-4062	397	10	(	(	PUNCT
gs-4062	397	11	ddi	ddi	PROPN
gs-4062	397	12	)	)	PUNCT
gs-4062	397	13	,	,	PUNCT
gs-4062	397	14	stavudine	stavudine	NOUN
gs-4062	397	15	(	(	PUNCT
gs-4062	397	16	d4	d4	PROPN
gs-4062	397	17	t	t	PROPN
gs-4062	397	18	)	)	PUNCT
gs-4062	397	19	(	(	PUNCT
gs-4062	397	20	largely	largely	ADV
gs-4062	397	21	historical	historical	ADJ
gs-4062	397	22	due	due	ADJ
gs-4062	397	23	to	to	ADP
gs-4062	397	24	toxicity	toxicity	NOUN
gs-4062	397	25	)	)	PUNCT
gs-4062	397	26	;	;	PUNCT
gs-4062	397	27	abacavir	abacavir	PROPN
gs-4062	397	28	(	(	PUNCT
gs-4062	397	29	abc	abc	PROPN
gs-4062	397	30	)	)	PUNCT
gs-4062	397	31	;	;	PUNCT
gs-4062	397	32	lamivudine	lamivudine	NOUN
gs-4062	397	33	(	(	PUNCT
gs-4062	397	34	3tc	3tc	NOUN
gs-4062	397	35	)	)	PUNCT
gs-4062	397	36	;	;	PUNCT
gs-4062	397	37	emtricitabine	emtricitabine	PROPN
gs-4062	397	38	(	(	PUNCT
gs-4062	397	39	ftc	ftc	PROPN
gs-4062	397	40	)	)	PUNCT
gs-4062	397	41	;	;	PUNCT
gs-4062	397	42	tenofovir	tenofovir	NOUN
gs-4062	397	43	disoproxil	disoproxil	VERB
gs-4062	397	44	fumarate	fumarate	NOUN
gs-4062	397	45	(	(	PUNCT
gs-4062	397	46	tdf	tdf	PROPN
gs-4062	397	47	)	)	PUNCT
gs-4062	397	48	;	;	PUNCT
gs-4062	397	49	tenofovir	tenofovir	PROPN
gs-4062	397	50	alafenamide	alafenamide	PROPN
gs-4062	397	51	(	(	PUNCT
gs-4062	397	52	taf	taf	NOUN
gs-4062	397	53	)	)	PUNCT
gs-4062	397	54	.	.	PUNCT
gs-4062	398	1	role	role	NOUN
gs-4062	398	2	:	:	PUNCT
gs-4062	398	3	nrtis	nrtis	PROPN
gs-4062	398	4	form	form	VERB
gs-4062	398	5	the	the	DET
gs-4062	398	6	foundational	foundational	ADJ
gs-4062	398	7	"	"	PUNCT
gs-4062	398	8	backbone	backbone	NOUN
gs-4062	398	9	"	"	PUNCT
gs-4062	398	10	of	of	ADP
gs-4062	398	11	most	most	ADJ
gs-4062	398	12	modern	modern	ADJ
gs-4062	398	13	combination	combination	NOUN
gs-4062	398	14	regimens	regimen	NOUN
gs-4062	398	15	,	,	PUNCT
gs-4062	398	16	typically	typically	ADV
gs-4062	398	17	used	use	VERB
gs-4062	398	18	in	in	ADP
gs-4062	398	19	pairs	pair	NOUN
gs-4062	398	20	(	(	PUNCT
gs-4062	398	21	e.g.	e.g.	ADV
gs-4062	398	22	,	,	PUNCT
gs-4062	398	23	taf	taf	PROPN
gs-4062	398	24	/	/	SYM
gs-4062	398	25	ftc	ftc	PROPN
gs-4062	398	26	or	or	CCONJ
gs-4062	398	27	abc/3tc	abc/3tc	PROPN
gs-4062	398	28	)	)	PUNCT
gs-4062	398	29	.	.	PUNCT
gs-4062	399	1	non	non	ADJ
gs-4062	399	2	-	-	ADJ
gs-4062	399	3	nucleoside	nucleoside	ADJ
gs-4062	399	4	reverse	reverse	ADJ
gs-4062	399	5	transcriptase	transcriptase	NOUN
gs-4062	399	6	inhibitors	inhibitor	NOUN
gs-4062	399	7	(	(	PUNCT
gs-4062	399	8	nnrtis	nnrtis	ADJ
gs-4062	399	9	):	):	PUNCT
gs-4062	399	10	nnrtis	nnrtis	PROPN
gs-4062	399	11	are	be	AUX
gs-4062	399	12	non	non	ADJ
gs-4062	399	13	-	-	ADJ
gs-4062	399	14	competitive	competitive	ADJ
gs-4062	399	15	inhibitors	inhibitor	NOUN
gs-4062	399	16	of	of	ADP
gs-4062	399	17	hiv	hiv	PROPN
gs-4062	399	18	reverse	reverse	NOUN
gs-4062	399	19	transcriptase	transcriptase	VERB
gs-4062	399	20	.	.	PUNCT
gs-4062	400	1	they	they	PRON
gs-4062	400	2	bind	bind	VERB
gs-4062	400	3	to	to	ADP
gs-4062	400	4	a	a	DET
gs-4062	400	5	hydrophobic	hydrophobic	NOUN
gs-4062	400	6	pocket	pocket	NOUN
gs-4062	400	7	distal	distal	NOUN
gs-4062	400	8	to	to	ADP
gs-4062	400	9	the	the	DET
gs-4062	400	10	enzyme	enzyme	NOUN
gs-4062	400	11	's	's	PART
gs-4062	400	12	active	active	ADJ
gs-4062	400	13	site	site	NOUN
gs-4062	400	14	(	(	PUNCT
gs-4062	400	15	the	the	DET
gs-4062	400	16	nnrti	nnrti	NOUN
gs-4062	400	17	pocket	pocket	NOUN
gs-4062	400	18	)	)	PUNCT
gs-4062	400	19	,	,	PUNCT
gs-4062	400	20	inducing	induce	VERB
gs-4062	400	21	a	a	DET
gs-4062	400	22	conformational	conformational	ADJ
gs-4062	400	23	change	change	NOUN
gs-4062	400	24	that	that	PRON
gs-4062	400	25	drastically	drastically	ADV
gs-4062	400	26	reduces	reduce	VERB
gs-4062	400	27	the	the	DET
gs-4062	400	28	enzyme	enzyme	NOUN
gs-4062	400	29	's	's	PART
gs-4062	400	30	catalytic	catalytic	ADJ
gs-4062	400	31	activity	activity	NOUN
gs-4062	400	32	.	.	PUNCT
gs-4062	401	1	their	their	PRON
gs-4062	401	2	mechanism	mechanism	NOUN
gs-4062	401	3	is	be	AUX
gs-4062	401	4	distinct	distinct	ADJ
gs-4062	401	5	from	from	ADP
gs-4062	401	6	and	and	CCONJ
gs-4062	401	7	synergistic	synergistic	ADJ
gs-4062	401	8	with	with	ADP
gs-4062	401	9	that	that	PRON
gs-4062	401	10	of	of	ADP
gs-4062	401	11	nrtis	nrtis	PROPN
gs-4062	401	12	.	.	PUNCT
gs-4062	402	1	key	key	ADJ
gs-4062	402	2	agents	agent	NOUN
gs-4062	402	3	:	:	PUNCT
gs-4062	402	4	nevirapine	nevirapine	PROPN
gs-4062	402	5	(	(	PUNCT
gs-4062	402	6	nvp	nvp	NOUN
gs-4062	402	7	)	)	PUNCT
gs-4062	402	8	,	,	PUNCT
gs-4062	402	9	efavirenz	efavirenz	NOUN
gs-4062	402	10	(	(	PUNCT
gs-4062	402	11	efv	efv	ADJ
gs-4062	402	12	)	)	PUNCT
gs-4062	402	13	(	(	PUNCT
gs-4062	402	14	first	first	ADJ
gs-4062	402	15	-	-	PUNCT
gs-4062	402	16	generation	generation	NOUN
gs-4062	402	17	)	)	PUNCT
gs-4062	402	18	;	;	PUNCT
gs-4062	402	19	etravirine	etravirine	NOUN
gs-4062	402	20	(	(	PUNCT
gs-4062	402	21	etr	etr	PROPN
gs-4062	402	22	)	)	PUNCT
gs-4062	402	23	,	,	PUNCT
gs-4062	402	24	rilpivirine	rilpivirine	X
gs-4062	402	25	(	(	PUNCT
gs-4062	402	26	rpv	rpv	NOUN
gs-4062	402	27	)	)	PUNCT
gs-4062	402	28	(	(	PUNCT
gs-4062	402	29	second	second	ADJ
gs-4062	402	30	-	-	PUNCT
gs-4062	402	31	generation	generation	NOUN
gs-4062	402	32	)	)	PUNCT
gs-4062	402	33	;	;	PUNCT
gs-4062	402	34	doravirine	doravirine	ADJ
gs-4062	402	35	(	(	PUNCT
gs-4062	402	36	dor	dor	PROPN
gs-4062	402	37	)	)	PUNCT
gs-4062	402	38	(	(	PUNCT
gs-4062	402	39	newest	new	ADJ
gs-4062	402	40	generation	generation	NOUN
gs-4062	402	41	)	)	PUNCT
gs-4062	402	42	.	.	PUNCT
gs-4062	403	1	role	role	NOUN
gs-4062	403	2	:	:	PUNCT
gs-4062	403	3	historically	historically	ADV
gs-4062	403	4	used	use	VERB
gs-4062	403	5	as	as	ADP
gs-4062	403	6	a	a	DET
gs-4062	403	7	"	"	PUNCT
gs-4062	403	8	third	third	ADJ
gs-4062	403	9	agent	agent	NOUN
gs-4062	403	10	"	"	PUNCT
gs-4062	403	11	or	or	CCONJ
gs-4062	403	12	cornerstone	cornerstone	NOUN
gs-4062	403	13	in	in	ADP
gs-4062	403	14	first	first	ADJ
gs-4062	403	15	-	-	PUNCT
gs-4062	403	16	line	line	NOUN
gs-4062	403	17	regimens	regimen	NOUN
gs-4062	403	18	.	.	PUNCT
gs-4062	404	1	newer	new	ADJ
gs-4062	404	2	agents	agent	NOUN
gs-4062	404	3	like	like	ADP
gs-4062	404	4	dor	dor	PROPN
gs-4062	404	5	offer	offer	VERB
gs-4062	404	6	improved	improve	VERB
gs-4062	404	7	resistance	resistance	NOUN
gs-4062	404	8	and	and	CCONJ
gs-4062	404	9	tolerability	tolerability	NOUN
gs-4062	404	10	profiles	profile	NOUN
gs-4062	404	11	.	.	PUNCT
gs-4062	405	1	georgian	georgian	NOUN
gs-4062	405	2	scientists/	scientists/	NUM
gs-4062	405	3	.	.	PUNCT
gs-4062	406	1	7	7	NUM
gs-4062	406	2	n	n	PRON
gs-4062	406	3	3	3	NUM
gs-4062	406	4	,	,	PUNCT
gs-4062	406	5	2025	2025	NUM
gs-4062	406	6	540	540	NUM
gs-4062	406	7	protease	protease	NOUN
gs-4062	406	8	inhibitors	inhibitor	NOUN
gs-4062	406	9	(	(	PUNCT
gs-4062	406	10	pis	pis	ADJ
gs-4062	406	11	):	):	PUNCT
gs-4062	406	12	pis	pis	NOUN
gs-4062	406	13	target	target	VERB
gs-4062	406	14	the	the	DET
gs-4062	406	15	hiv-1	hiv-1	X
gs-4062	406	16	protease	protease	NOUN
gs-4062	406	17	enzyme	enzyme	NOUN
gs-4062	406	18	,	,	PUNCT
gs-4062	406	19	which	which	PRON
gs-4062	406	20	is	be	AUX
gs-4062	406	21	essential	essential	ADJ
gs-4062	406	22	for	for	ADP
gs-4062	406	23	the	the	DET
gs-4062	406	24	posttranslational	posttranslational	ADJ
gs-4062	406	25	processing	processing	NOUN
gs-4062	406	26	of	of	ADP
gs-4062	406	27	viral	viral	ADJ
gs-4062	406	28	polyproteins	polyprotein	NOUN
gs-4062	406	29	(	(	PUNCT
gs-4062	406	30	gag	gag	NOUN
gs-4062	406	31	and	and	CCONJ
gs-4062	406	32	gag	gag	NOUN
gs-4062	406	33	-	-	PUNCT
gs-4062	406	34	pol	pol	NOUN
gs-4062	406	35	)	)	PUNCT
gs-4062	406	36	into	into	ADP
gs-4062	406	37	mature	mature	ADJ
gs-4062	406	38	,	,	PUNCT
gs-4062	406	39	functional	functional	ADJ
gs-4062	406	40	proteins	protein	NOUN
gs-4062	406	41	(	(	PUNCT
gs-4062	406	42	e.g.	e.g.	ADV
gs-4062	406	43	,	,	PUNCT
gs-4062	406	44	protease	protease	NOUN
gs-4062	406	45	,	,	PUNCT
gs-4062	406	46	reverse	reverse	ADJ
gs-4062	406	47	transcriptase	transcriptase	NOUN
gs-4062	406	48	,	,	PUNCT
gs-4062	406	49	integrase	integrase	NOUN
gs-4062	406	50	,	,	PUNCT
gs-4062	406	51	structural	structural	ADJ
gs-4062	406	52	proteins	protein	NOUN
gs-4062	406	53	)	)	PUNCT
gs-4062	406	54	.	.	PUNCT
gs-4062	407	1	inhibition	inhibition	NOUN
gs-4062	407	2	results	result	NOUN
gs-4062	407	3	in	in	ADP
gs-4062	407	4	the	the	DET
gs-4062	407	5	production	production	NOUN
gs-4062	407	6	of	of	ADP
gs-4062	407	7	immature	immature	ADJ
gs-4062	407	8	,	,	PUNCT
gs-4062	407	9	non	non	ADJ
gs-4062	407	10	-	-	ADJ
gs-4062	407	11	infectious	infectious	ADJ
gs-4062	407	12	viral	viral	ADJ
gs-4062	407	13	particles	particle	NOUN
gs-4062	407	14	.	.	PUNCT
gs-4062	408	1	key	key	ADJ
gs-4062	408	2	agents	agent	NOUN
gs-4062	408	3	:	:	PUNCT
gs-4062	408	4	early	early	ADV
gs-4062	408	5	pis	pis	NOUN
gs-4062	408	6	like	like	ADP
gs-4062	408	7	indinavir	indinavir	NOUN
gs-4062	408	8	(	(	PUNCT
gs-4062	408	9	idv	idv	PROPN
gs-4062	408	10	)	)	PUNCT
gs-4062	408	11	;	;	PUNCT
gs-4062	408	12	boosted	boost	VERB
gs-4062	408	13	pis	pis	NOUN
gs-4062	408	14	like	like	ADP
gs-4062	408	15	lopinavir	lopinavir	PROPN
gs-4062	408	16	/	/	SYM
gs-4062	408	17	ritonavir	ritonavir	PROPN
gs-4062	408	18	(	(	PUNCT
gs-4062	408	19	lpv	lpv	PROPN
gs-4062	408	20	/	/	SYM
gs-4062	408	21	r	r	NOUN
gs-4062	408	22	)	)	PUNCT
gs-4062	408	23	,	,	PUNCT
gs-4062	408	24	darunavir	darunavir	PROPN
gs-4062	408	25	/	/	SYM
gs-4062	408	26	ritonavir	ritonavir	PROPN
gs-4062	408	27	or	or	CCONJ
gs-4062	408	28	/cobicistat	/cobicistat	INTJ
gs-4062	408	29	(	(	PUNCT
gs-4062	408	30	drv	drv	NOUN
gs-4062	408	31	/	/	SYM
gs-4062	408	32	b	b	NOUN
gs-4062	408	33	)	)	PUNCT
gs-4062	408	34	.	.	PUNCT
gs-4062	409	1	role	role	NOUN
gs-4062	409	2	:	:	PUNCT
gs-4062	409	3	now	now	ADV
gs-4062	409	4	primarily	primarily	ADV
gs-4062	409	5	reserved	reserve	VERB
gs-4062	409	6	for	for	ADP
gs-4062	409	7	second	second	ADJ
gs-4062	409	8	-	-	PUNCT
gs-4062	409	9	line	line	NOUN
gs-4062	409	10	therapy	therapy	NOUN
gs-4062	409	11	,	,	PUNCT
gs-4062	409	12	treatment	treatment	NOUN
gs-4062	409	13	-	-	PUNCT
gs-4062	409	14	experienced	experience	VERB
gs-4062	409	15	patients	patient	NOUN
gs-4062	409	16	,	,	PUNCT
gs-4062	409	17	or	or	CCONJ
gs-4062	409	18	specific	specific	ADJ
gs-4062	409	19	clinical	clinical	ADJ
gs-4062	409	20	scenarios	scenario	NOUN
gs-4062	409	21	(	(	PUNCT
gs-4062	409	22	e.g.	e.g.	ADV
gs-4062	409	23	,	,	PUNCT
gs-4062	409	24	pregnancy	pregnancy	NOUN
gs-4062	409	25	with	with	ADP
gs-4062	409	26	resistance	resistance	NOUN
gs-4062	409	27	concerns	concern	NOUN
gs-4062	409	28	)	)	PUNCT
gs-4062	409	29	due	due	ADP
gs-4062	409	30	to	to	ADP
gs-4062	409	31	the	the	DET
gs-4062	409	32	potency	potency	NOUN
gs-4062	409	33	and	and	CCONJ
gs-4062	409	34	tolerability	tolerability	NOUN
gs-4062	409	35	of	of	ADP
gs-4062	409	36	newer	new	ADJ
gs-4062	409	37	classes	class	NOUN
gs-4062	409	38	.	.	PUNCT
gs-4062	410	1	they	they	PRON
gs-4062	410	2	require	require	VERB
gs-4062	410	3	pharmacokinetic	pharmacokinetic	ADJ
gs-4062	410	4	"	"	PUNCT
gs-4062	410	5	boosters	booster	NOUN
gs-4062	410	6	"	"	PUNCT
gs-4062	410	7	(	(	PUNCT
gs-4062	410	8	ritonavir	ritonavir	PROPN
gs-4062	410	9	or	or	CCONJ
gs-4062	410	10	cobicistat	cobicistat	NOUN
gs-4062	410	11	)	)	PUNCT
gs-4062	410	12	to	to	PART
gs-4062	410	13	prolong	prolong	VERB
gs-4062	410	14	their	their	PRON
gs-4062	410	15	half	half	ADJ
gs-4062	410	16	-	-	PUNCT
gs-4062	410	17	life	life	NOUN
gs-4062	410	18	.	.	PUNCT
gs-4062	411	1	integrase	integrase	NOUN
gs-4062	411	2	strand	strand	NOUN
gs-4062	411	3	transfer	transfer	NOUN
gs-4062	411	4	inhibitors	inhibitor	NOUN
gs-4062	411	5	(	(	PUNCT
gs-4062	411	6	instis	instis	PROPN
gs-4062	411	7	)	)	PUNCT
gs-4062	411	8	the	the	DET
gs-4062	411	9	modern	modern	ADJ
gs-4062	411	10	cornerstone	cornerstone	NOUN
gs-4062	411	11	instis	instis	PROPN
gs-4062	411	12	represent	represent	VERB
gs-4062	411	13	the	the	DET
gs-4062	411	14	most	most	ADV
gs-4062	411	15	significant	significant	ADJ
gs-4062	411	16	advancement	advancement	NOUN
gs-4062	411	17	in	in	ADP
gs-4062	411	18	hiv	hiv	PROPN
gs-4062	411	19	therapeutics	therapeutic	NOUN
gs-4062	411	20	in	in	ADP
gs-4062	411	21	the	the	DET
gs-4062	411	22	past	past	ADJ
gs-4062	411	23	15	15	NUM
gs-4062	411	24	years	year	NOUN
gs-4062	411	25	.	.	PUNCT
gs-4062	412	1	they	they	PRON
gs-4062	412	2	inhibit	inhibit	VERB
gs-4062	412	3	the	the	DET
gs-4062	412	4	hiv	hiv	PROPN
gs-4062	412	5	integrase	integrase	PROPN
gs-4062	412	6	enzyme	enzyme	NOUN
gs-4062	412	7	,	,	PUNCT
gs-4062	412	8	which	which	PRON
gs-4062	412	9	is	be	AUX
gs-4062	412	10	responsible	responsible	ADJ
gs-4062	412	11	for	for	ADP
gs-4062	412	12	inserting	insert	VERB
gs-4062	412	13	the	the	DET
gs-4062	412	14	viral	viral	ADJ
gs-4062	412	15	dna	dna	NOUN
gs-4062	412	16	(	(	PUNCT
gs-4062	412	17	produced	produce	VERB
gs-4062	412	18	by	by	ADP
gs-4062	412	19	reverse	reverse	ADJ
gs-4062	412	20	transcriptase	transcriptase	NOUN
gs-4062	412	21	)	)	PUNCT
gs-4062	412	22	into	into	ADP
gs-4062	412	23	the	the	DET
gs-4062	412	24	host	host	NOUN
gs-4062	412	25	cell	cell	NOUN
gs-4062	412	26	's	's	PART
gs-4062	412	27	chromosome	chromosome	NOUN
gs-4062	412	28	,	,	PUNCT
gs-4062	412	29	forming	form	VERB
gs-4062	412	30	a	a	DET
gs-4062	412	31	permanent	permanent	ADJ
gs-4062	412	32	provirus	provirus	NOUN
gs-4062	412	33	.	.	PUNCT
gs-4062	413	1	instis	instis	PROPN
gs-4062	413	2	specifically	specifically	ADV
gs-4062	413	3	block	block	VERB
gs-4062	413	4	the	the	DET
gs-4062	413	5	strand	strand	NOUN
gs-4062	413	6	transfer	transfer	NOUN
gs-4062	413	7	step	step	NOUN
gs-4062	413	8	of	of	ADP
gs-4062	413	9	this	this	DET
gs-4062	413	10	integration	integration	NOUN
gs-4062	413	11	process	process	NOUN
gs-4062	413	12	.	.	PUNCT
gs-4062	414	1	key	key	ADJ
gs-4062	414	2	agents	agent	NOUN
gs-4062	414	3	:	:	PUNCT
gs-4062	414	4	raltegravir	raltegravir	PROPN
gs-4062	414	5	(	(	PUNCT
gs-4062	414	6	ral	ral	PROPN
gs-4062	414	7	)	)	PUNCT
gs-4062	414	8	(	(	PUNCT
gs-4062	414	9	first	first	ADJ
gs-4062	414	10	-	-	PUNCT
gs-4062	414	11	in	in	ADP
gs-4062	414	12	-	-	PUNCT
gs-4062	414	13	class	class	NOUN
gs-4062	414	14	)	)	PUNCT
gs-4062	414	15	;	;	PUNCT
gs-4062	414	16	elvitegravir	elvitegravir	PROPN
gs-4062	414	17	(	(	PUNCT
gs-4062	414	18	evg	evg	PROPN
gs-4062	414	19	)	)	PUNCT
gs-4062	414	20	(	(	PUNCT
gs-4062	414	21	requires	require	VERB
gs-4062	414	22	pharmacoenhancement	pharmacoenhancement	NOUN
gs-4062	414	23	)	)	PUNCT
gs-4062	414	24	;	;	PUNCT
gs-4062	414	25	dolutegravir	dolutegravir	PROPN
gs-4062	414	26	(	(	PUNCT
gs-4062	414	27	dtg	dtg	PROPN
gs-4062	414	28	)	)	PUNCT
gs-4062	414	29	(	(	PUNCT
gs-4062	414	30	second	second	ADJ
gs-4062	414	31	-	-	PUNCT
gs-4062	414	32	generation	generation	NOUN
gs-4062	414	33	)	)	PUNCT
gs-4062	414	34	;	;	PUNCT
gs-4062	414	35	bictegravir	bictegravir	PROPN
gs-4062	414	36	(	(	PUNCT
gs-4062	414	37	bic	bic	PROPN
gs-4062	414	38	)	)	PUNCT
gs-4062	414	39	(	(	PUNCT
gs-4062	414	40	nextgeneration	nextgeneration	NOUN
gs-4062	414	41	)	)	PUNCT
gs-4062	414	42	.	.	PUNCT
gs-4062	415	1	role	role	NOUN
gs-4062	415	2	:	:	PUNCT
gs-4062	416	1	instis	insti	NOUN
gs-4062	416	2	are	be	AUX
gs-4062	416	3	now	now	ADV
gs-4062	416	4	the	the	DET
gs-4062	416	5	preferred	prefer	VERB
gs-4062	416	6	and	and	CCONJ
gs-4062	416	7	recommended	recommend	VERB
gs-4062	416	8	"	"	PUNCT
gs-4062	416	9	third	third	ADJ
gs-4062	416	10	agents	agent	NOUN
gs-4062	416	11	"	"	PUNCT
gs-4062	416	12	in	in	ADP
gs-4062	416	13	first	first	ADJ
gs-4062	416	14	-	-	PUNCT
gs-4062	416	15	line	line	NOUN
gs-4062	416	16	regimens	regimen	NOUN
gs-4062	416	17	for	for	ADP
gs-4062	416	18	most	most	ADJ
gs-4062	416	19	patients	patient	NOUN
gs-4062	416	20	globally	globally	ADV
gs-4062	416	21	due	due	ADP
gs-4062	416	22	to	to	ADP
gs-4062	416	23	their	their	PRON
gs-4062	416	24	superior	superior	ADJ
gs-4062	416	25	potency	potency	NOUN
gs-4062	416	26	,	,	PUNCT
gs-4062	416	27	high	high	ADJ
gs-4062	416	28	genetic	genetic	ADJ
gs-4062	416	29	barrier	barrier	NOUN
gs-4062	416	30	to	to	ADP
gs-4062	416	31	resistance	resistance	NOUN
gs-4062	416	32	,	,	PUNCT
gs-4062	416	33	and	and	CCONJ
gs-4062	416	34	generally	generally	ADV
gs-4062	416	35	favorable	favorable	ADJ
gs-4062	416	36	tolerability	tolerability	NOUN
gs-4062	416	37	.	.	PUNCT
gs-4062	417	1	entry	entry	NOUN
gs-4062	417	2	and	and	CCONJ
gs-4062	417	3	fusion	fusion	NOUN
gs-4062	417	4	inhibitors	inhibitor	NOUN
gs-4062	417	5	:	:	PUNCT
gs-4062	417	6	this	this	DET
gs-4062	417	7	class	class	NOUN
gs-4062	417	8	prevents	prevent	VERB
gs-4062	417	9	hiv	hiv	PROPN
gs-4062	417	10	from	from	ADP
gs-4062	417	11	entering	enter	VERB
gs-4062	417	12	susceptible	susceptible	ADJ
gs-4062	417	13	host	host	NOUN
gs-4062	417	14	cells	cell	NOUN
gs-4062	417	15	(	(	PUNCT
gs-4062	417	16	primarily	primarily	ADV
gs-4062	417	17	cd4	cd4	PROPN
gs-4062	417	18	+	+	PROPN
gs-4062	417	19	t	t	PROPN
gs-4062	417	20	-	-	PUNCT
gs-4062	417	21	cells	cell	NOUN
gs-4062	417	22	)	)	PUNCT
gs-4062	417	23	.	.	PUNCT
gs-4062	418	1	they	they	PRON
gs-4062	418	2	target	target	VERB
gs-4062	418	3	the	the	DET
gs-4062	418	4	complex	complex	ADJ
gs-4062	418	5	process	process	NOUN
gs-4062	418	6	of	of	ADP
gs-4062	418	7	viral	viral	ADJ
gs-4062	418	8	entry	entry	NOUN
gs-4062	418	9	,	,	PUNCT
gs-4062	418	10	which	which	PRON
gs-4062	418	11	involves	involve	VERB
gs-4062	418	12	attachment	attachment	NOUN
gs-4062	418	13	to	to	ADP
gs-4062	418	14	the	the	DET
gs-4062	418	15	cd4	cd4	PROPN
gs-4062	418	16	receptor	receptor	NOUN
gs-4062	418	17	and	and	CCONJ
gs-4062	418	18	ccr5	ccr5	NOUN
gs-4062	418	19	or	or	CCONJ
gs-4062	418	20	cxcr4	cxcr4	NOUN
gs-4062	418	21	coreceptors	coreceptor	NOUN
gs-4062	418	22	,	,	PUNCT
gs-4062	418	23	followed	follow	VERB
gs-4062	418	24	by	by	ADP
gs-4062	418	25	fusion	fusion	NOUN
gs-4062	418	26	of	of	ADP
gs-4062	418	27	the	the	DET
gs-4062	418	28	viral	viral	ADJ
gs-4062	418	29	and	and	CCONJ
gs-4062	418	30	cellular	cellular	ADJ
gs-4062	418	31	membranes	membrane	NOUN
gs-4062	418	32	.	.	PUNCT
gs-4062	419	1	key	key	ADJ
gs-4062	419	2	agents	agent	NOUN
gs-4062	419	3	:	:	PUNCT
gs-4062	419	4	enfuvirtide	enfuvirtide	ADJ
gs-4062	419	5	(	(	PUNCT
gs-4062	419	6	t-20	t-20	PROPN
gs-4062	419	7	)	)	PUNCT
gs-4062	419	8	(	(	PUNCT
gs-4062	419	9	fusion	fusion	NOUN
gs-4062	419	10	inhibitor	inhibitor	NOUN
gs-4062	419	11	,	,	PUNCT
gs-4062	419	12	injectable	injectable	ADJ
gs-4062	419	13	,	,	PUNCT
gs-4062	419	14	largely	largely	ADV
gs-4062	419	15	historical	historical	ADJ
gs-4062	419	16	)	)	PUNCT
gs-4062	419	17	;	;	PUNCT
gs-4062	419	18	maraviroc	maraviroc	NOUN
gs-4062	419	19	(	(	PUNCT
gs-4062	419	20	mvc	mvc	NOUN
gs-4062	419	21	)	)	PUNCT
gs-4062	419	22	(	(	PUNCT
gs-4062	419	23	ccr5	ccr5	NOUN
gs-4062	419	24	antagonist	antagonist	NOUN
gs-4062	419	25	,	,	PUNCT
gs-4062	419	26	requires	require	VERB
gs-4062	419	27	tropism	tropism	ADJ
gs-4062	419	28	testing	testing	NOUN
gs-4062	419	29	)	)	PUNCT
gs-4062	419	30	;	;	PUNCT
gs-4062	419	31	ibalizumab	ibalizumab	X
gs-4062	419	32	(	(	PUNCT
gs-4062	419	33	iba	iba	PROPN
gs-4062	419	34	)	)	PUNCT
gs-4062	419	35	(	(	PUNCT
gs-4062	419	36	post	post	ADJ
gs-4062	419	37	-	-	ADJ
gs-4062	419	38	attachment	attachment	ADJ
gs-4062	419	39	inhibitor	inhibitor	NOUN
gs-4062	419	40	,	,	PUNCT
gs-4062	419	41	monoclonal	monoclonal	NOUN
gs-4062	419	42	antibody	antibody	NOUN
gs-4062	419	43	)	)	PUNCT
gs-4062	419	44	;	;	PUNCT
gs-4062	419	45	fostemsavir	fostemsavir	PROPN
gs-4062	419	46	(	(	PUNCT
gs-4062	419	47	ftr	ftr	PROPN
gs-4062	419	48	)	)	PUNCT
gs-4062	419	49	(	(	PUNCT
gs-4062	419	50	attachment	attachment	NOUN
gs-4062	419	51	inhibitor	inhibitor	NOUN
gs-4062	419	52	,	,	PUNCT
gs-4062	419	53	prodrug	prodrug	NOUN
gs-4062	419	54	of	of	ADP
gs-4062	419	55	temsavir	temsavir	PROPN
gs-4062	419	56	)	)	PUNCT
gs-4062	419	57	.	.	PUNCT
gs-4062	420	1	role	role	NOUN
gs-4062	420	2	:	:	PUNCT
gs-4062	420	3	primarily	primarily	ADV
gs-4062	420	4	used	use	VERB
gs-4062	420	5	as	as	ADP
gs-4062	420	6	salvage	salvage	NOUN
gs-4062	420	7	therapy	therapy	NOUN
gs-4062	420	8	for	for	ADP
gs-4062	420	9	heavily	heavily	ADV
gs-4062	420	10	treatment	treatment	NOUN
gs-4062	420	11	-	-	PUNCT
gs-4062	420	12	experienced	experience	VERB
gs-4062	420	13	patients	patient	NOUN
gs-4062	420	14	with	with	ADP
gs-4062	420	15	multidrug	multidrug	NOUN
gs-4062	420	16	-	-	PUNCT
gs-4062	420	17	resistant	resistant	ADJ
gs-4062	420	18	(	(	PUNCT
gs-4062	420	19	mdr	mdr	PROPN
gs-4062	420	20	)	)	PUNCT
gs-4062	420	21	hiv	hiv	PROPN
gs-4062	420	22	.	.	PUNCT
gs-4062	421	1	pharmacokinetic	pharmacokinetic	ADJ
gs-4062	421	2	enhancers	enhancer	NOUN
gs-4062	421	3	(	(	PUNCT
gs-4062	421	4	"	"	PUNCT
gs-4062	421	5	boosters	booster	NOUN
gs-4062	421	6	"	"	PUNCT
gs-4062	421	7	):	):	PUNCT
gs-4062	421	8	while	while	SCONJ
gs-4062	421	9	not	not	PART
gs-4062	421	10	antivirals	antiviral	NOUN
gs-4062	421	11	themselves	themselves	PRON
gs-4062	421	12	,	,	PUNCT
gs-4062	421	13	these	these	DET
gs-4062	421	14	agents	agent	NOUN
gs-4062	421	15	are	be	AUX
gs-4062	421	16	critical	critical	ADJ
gs-4062	421	17	components	component	NOUN
gs-4062	421	18	of	of	ADP
gs-4062	421	19	many	many	ADJ
gs-4062	421	20	regimens	regimen	NOUN
gs-4062	421	21	.	.	PUNCT
gs-4062	422	1	they	they	PRON
gs-4062	422	2	potently	potently	ADV
gs-4062	422	3	inhibit	inhibit	VERB
gs-4062	422	4	the	the	DET
gs-4062	422	5	cytochrome	cytochrome	NOUN
gs-4062	422	6	p450	p450	PROPN
gs-4062	422	7	3a4	3a4	NUM
gs-4062	422	8	(	(	PUNCT
gs-4062	422	9	cyp3a4	cyp3a4	NOUN
gs-4062	422	10	)	)	PUNCT
gs-4062	422	11	enzyme	enzyme	NOUN
gs-4062	422	12	in	in	ADP
gs-4062	422	13	the	the	DET
gs-4062	422	14	gut	gut	NOUN
gs-4062	422	15	and	and	CCONJ
gs-4062	422	16	liver	liver	NOUN
gs-4062	422	17	,	,	PUNCT
gs-4062	422	18	which	which	PRON
gs-4062	422	19	is	be	AUX
gs-4062	422	20	responsible	responsible	ADJ
gs-4062	422	21	for	for	ADP
gs-4062	422	22	metabolizing	metabolize	VERB
gs-4062	422	23	several	several	ADJ
gs-4062	422	24	arvs	arvs	NOUN
gs-4062	422	25	(	(	PUNCT
gs-4062	422	26	notably	notably	ADV
gs-4062	422	27	pis	pis	ADJ
gs-4062	422	28	and	and	CCONJ
gs-4062	422	29	evg	evg	NOUN
gs-4062	422	30	)	)	PUNCT
gs-4062	422	31	.	.	PUNCT
gs-4062	423	1	by	by	ADP
gs-4062	423	2	inhibiting	inhibit	VERB
gs-4062	423	3	this	this	DET
gs-4062	423	4	metabolism	metabolism	NOUN
gs-4062	423	5	,	,	PUNCT
gs-4062	423	6	they	they	PRON
gs-4062	423	7	significantly	significantly	ADV
gs-4062	423	8	increase	increase	VERB
gs-4062	423	9	the	the	DET
gs-4062	423	10	exposure	exposure	NOUN
gs-4062	423	11	(	(	PUNCT
gs-4062	423	12	auc	auc	NOUN
gs-4062	423	13	)	)	PUNCT
gs-4062	423	14	and	and	CCONJ
gs-4062	423	15	half	half	ADJ
gs-4062	423	16	-	-	PUNCT
gs-4062	423	17	life	life	NOUN
gs-4062	423	18	of	of	ADP
gs-4062	423	19	the	the	DET
gs-4062	423	20	co	co	ADJ
gs-4062	423	21	-	-	ADJ
gs-4062	423	22	administered	administered	ADJ
gs-4062	423	23	drug	drug	NOUN
gs-4062	423	24	,	,	PUNCT
gs-4062	423	25	allowing	allow	VERB
gs-4062	423	26	for	for	ADP
gs-4062	423	27	less	less	ADV
gs-4062	423	28	frequent	frequent	ADJ
gs-4062	423	29	dosing	dose	VERB
gs-4062	423	30	and	and	CCONJ
gs-4062	423	31	improved	improved	ADJ
gs-4062	423	32	efficacy	efficacy	NOUN
gs-4062	423	33	.	.	PUNCT
gs-4062	424	1	key	key	ADJ
gs-4062	424	2	agents	agent	NOUN
gs-4062	424	3	:	:	PUNCT
gs-4062	424	4	ritonavir	ritonavir	PROPN
gs-4062	424	5	(	(	PUNCT
gs-4062	424	6	rtv	rtv	PROPN
gs-4062	424	7	)	)	PUNCT
gs-4062	424	8	(	(	PUNCT
gs-4062	424	9	low	low	ADJ
gs-4062	424	10	-	-	PUNCT
gs-4062	424	11	dose	dose	NOUN
gs-4062	424	12	)	)	PUNCT
gs-4062	424	13	;	;	PUNCT
gs-4062	424	14	cobicistat	cobicistat	NOUN
gs-4062	424	15	(	(	PUNCT
gs-4062	424	16	cobi	cobi	PROPN
gs-4062	424	17	)	)	PUNCT
gs-4062	424	18	(	(	PUNCT
gs-4062	424	19	developed	develop	VERB
gs-4062	424	20	specifically	specifically	ADV
gs-4062	424	21	as	as	ADP
gs-4062	424	22	a	a	DET
gs-4062	424	23	pharmacoenhancer	pharmacoenhancer	NOUN
gs-4062	424	24	with	with	ADP
gs-4062	424	25	no	no	DET
gs-4062	424	26	antiviral	antiviral	ADJ
gs-4062	424	27	activity	activity	NOUN
gs-4062	424	28	itself	itself	PRON
gs-4062	424	29	)	)	PUNCT
gs-4062	424	30	.	.	PUNCT
gs-4062	425	1	mechanisms	mechanism	NOUN
gs-4062	425	2	of	of	ADP
gs-4062	425	3	action	action	NOUN
gs-4062	425	4	:	:	PUNCT
gs-4062	425	5	a	a	DET
gs-4062	425	6	molecular	molecular	ADJ
gs-4062	425	7	perspective	perspective	NOUN
gs-4062	425	8	on	on	ADP
gs-4062	425	9	viral	viral	ADJ
gs-4062	425	10	inhibition	inhibition	NOUN
gs-4062	425	11	understanding	understand	VERB
gs-4062	425	12	the	the	DET
gs-4062	425	13	precise	precise	ADJ
gs-4062	425	14	mechanism	mechanism	NOUN
gs-4062	425	15	of	of	ADP
gs-4062	425	16	action	action	NOUN
gs-4062	425	17	of	of	ADP
gs-4062	425	18	each	each	DET
gs-4062	425	19	drug	drug	NOUN
gs-4062	425	20	class	class	NOUN
gs-4062	425	21	is	be	AUX
gs-4062	425	22	fundamental	fundamental	ADJ
gs-4062	425	23	to	to	ADP
gs-4062	425	24	appreciating	appreciate	VERB
gs-4062	425	25	their	their	PRON
gs-4062	425	26	clinical	clinical	ADJ
gs-4062	425	27	utility	utility	NOUN
gs-4062	425	28	,	,	PUNCT
gs-4062	425	29	synergy	synergy	NOUN
gs-4062	425	30	,	,	PUNCT
gs-4062	425	31	and	and	CCONJ
gs-4062	425	32	the	the	DET
gs-4062	425	33	basis	basis	NOUN
gs-4062	425	34	for	for	ADP
gs-4062	425	35	resistance	resistance	NOUN
gs-4062	425	36	.	.	PUNCT
gs-4062	426	1	inhibition	inhibition	NOUN
gs-4062	426	2	of	of	ADP
gs-4062	426	3	reverse	reverse	ADJ
gs-4062	426	4	transcription	transcription	NOUN
gs-4062	426	5	(	(	PUNCT
gs-4062	426	6	nrtis	nrtis	PROPN
gs-4062	426	7	&	&	CCONJ
gs-4062	426	8	nnrtis	nnrtis	ADJ
gs-4062	426	9	)	)	PUNCT
gs-4062	426	10	georgian	georgian	NOUN
gs-4062	426	11	scientists/	scientists/	NUM
gs-4062	426	12	.	.	PUNCT
gs-4062	427	1	7	7	NUM
gs-4062	427	2	n	n	PRON
gs-4062	427	3	3	3	NUM
gs-4062	427	4	,	,	PUNCT
gs-4062	427	5	2025	2025	NUM
gs-4062	427	6	541	541	NUM
gs-4062	427	7	nrtis	nrtis	NOUN
gs-4062	427	8	:	:	PUNCT
gs-4062	427	9	the	the	DET
gs-4062	427	10	mechanism	mechanism	NOUN
gs-4062	427	11	is	be	AUX
gs-4062	427	12	one	one	NUM
gs-4062	427	13	of	of	ADP
gs-4062	427	14	competitive	competitive	ADJ
gs-4062	427	15	inhibition	inhibition	NOUN
gs-4062	427	16	and	and	CCONJ
gs-4062	427	17	chain	chain	NOUN
gs-4062	427	18	termination	termination	NOUN
gs-4062	427	19	.	.	PUNCT
gs-4062	428	1	the	the	DET
gs-4062	428	2	intracellularly	intracellularly	ADV
gs-4062	428	3	phosphorylated	phosphorylate	VERB
gs-4062	428	4	nrti	nrti	NOUN
gs-4062	428	5	triphosphate	triphosphate	NOUN
gs-4062	428	6	competes	compete	VERB
gs-4062	428	7	with	with	ADP
gs-4062	428	8	its	its	PRON
gs-4062	428	9	natural	natural	ADJ
gs-4062	428	10	counterpart	counterpart	NOUN
gs-4062	428	11	(	(	PUNCT
gs-4062	428	12	e.g.	e.g.	ADV
gs-4062	428	13	,	,	PUNCT
gs-4062	428	14	ftc	ftc	PROPN
gs-4062	428	15	-	-	PUNCT
gs-4062	428	16	tp	tp	PROPN
gs-4062	428	17	competes	compete	VERB
gs-4062	428	18	with	with	ADP
gs-4062	428	19	dctp	dctp	PROPN
gs-4062	428	20	)	)	PUNCT
gs-4062	428	21	for	for	ADP
gs-4062	428	22	binding	bind	VERB
gs-4062	428	23	to	to	ADP
gs-4062	428	24	the	the	DET
gs-4062	428	25	active	active	ADJ
gs-4062	428	26	site	site	NOUN
gs-4062	428	27	of	of	ADP
gs-4062	428	28	reverse	reverse	ADJ
gs-4062	428	29	transcriptase	transcriptase	NOUN
gs-4062	428	30	.	.	PUNCT
gs-4062	429	1	once	once	ADV
gs-4062	429	2	incorporated	incorporate	VERB
gs-4062	429	3	,	,	PUNCT
gs-4062	429	4	the	the	DET
gs-4062	429	5	molecule	molecule	NOUN
gs-4062	429	6	lacks	lack	VERB
gs-4062	429	7	a	a	DET
gs-4062	429	8	3'-hydroxyl	3'-hydroxyl	PROPN
gs-4062	429	9	group	group	NOUN
gs-4062	429	10	,	,	PUNCT
gs-4062	429	11	which	which	PRON
gs-4062	429	12	is	be	AUX
gs-4062	429	13	necessary	necessary	ADJ
gs-4062	429	14	for	for	ADP
gs-4062	429	15	forming	form	VERB
gs-4062	429	16	the	the	DET
gs-4062	429	17	phosphodiester	phosphodiester	ADJ
gs-4062	429	18	bond	bond	NOUN
gs-4062	429	19	with	with	ADP
gs-4062	429	20	the	the	DET
gs-4062	429	21	next	next	ADJ
gs-4062	429	22	incoming	incoming	ADJ
gs-4062	429	23	nucleotide	nucleotide	NOUN
gs-4062	429	24	.	.	PUNCT
gs-4062	430	1	this	this	PRON
gs-4062	430	2	abruptly	abruptly	ADV
gs-4062	430	3	terminates	terminate	VERB
gs-4062	430	4	the	the	DET
gs-4062	430	5	elongating	elongate	VERB
gs-4062	430	6	dna	dna	NOUN
gs-4062	430	7	chain	chain	NOUN
gs-4062	430	8	.	.	PUNCT
gs-4062	431	1	nnrtis	nnrtis	PROPN
gs-4062	431	2	:	:	PUNCT
gs-4062	431	3	these	these	DET
gs-4062	431	4	agents	agent	NOUN
gs-4062	431	5	employ	employ	VERB
gs-4062	431	6	allosteric	allosteric	ADJ
gs-4062	431	7	inhibition	inhibition	NOUN
gs-4062	431	8	.	.	PUNCT
gs-4062	432	1	their	their	PRON
gs-4062	432	2	binding	bind	VERB
gs-4062	432	3	to	to	ADP
gs-4062	432	4	the	the	DET
gs-4062	432	5	nnrti	nnrti	NOUN
gs-4062	432	6	pocket	pocket	NOUN
gs-4062	432	7	induces	induce	VERB
gs-4062	432	8	a	a	DET
gs-4062	432	9	conformational	conformational	ADJ
gs-4062	432	10	change	change	NOUN
gs-4062	432	11	that	that	PRON
gs-4062	432	12	locks	lock	VERB
gs-4062	432	13	the	the	DET
gs-4062	432	14	enzyme	enzyme	NOUN
gs-4062	432	15	into	into	ADP
gs-4062	432	16	an	an	DET
gs-4062	432	17	inactive	inactive	ADJ
gs-4062	432	18	state	state	NOUN
gs-4062	432	19	.	.	PUNCT
gs-4062	433	1	the	the	DET
gs-4062	433	2	substrate	substrate	NOUN
gs-4062	433	3	-	-	PUNCT
gs-4062	433	4	binding	bind	VERB
gs-4062	433	5	pocket	pocket	NOUN
gs-4062	433	6	becomes	become	VERB
gs-4062	433	7	distorted	distort	VERB
gs-4062	433	8	,	,	PUNCT
gs-4062	433	9	preventing	prevent	VERB
gs-4062	433	10	the	the	DET
gs-4062	433	11	proper	proper	ADJ
gs-4062	433	12	positioning	positioning	NOUN
gs-4062	433	13	of	of	ADP
gs-4062	433	14	the	the	DET
gs-4062	433	15	nucleoside	nucleoside	NOUN
gs-4062	433	16	triphosphates	triphosphate	NOUN
gs-4062	433	17	for	for	ADP
gs-4062	433	18	catalysis	catalysis	NOUN
gs-4062	433	19	.	.	PUNCT
gs-4062	434	1	this	this	DET
gs-4062	434	2	mechanism	mechanism	NOUN
gs-4062	434	3	is	be	AUX
gs-4062	434	4	highly	highly	ADV
gs-4062	434	5	specific	specific	ADJ
gs-4062	434	6	to	to	ADP
gs-4062	434	7	the	the	DET
gs-4062	434	8	hiv-1	hiv-1	X
gs-4062	434	9	reverse	reverse	ADJ
gs-4062	434	10	transcriptase	transcriptase	NOUN
gs-4062	434	11	.	.	PUNCT
gs-4062	435	1	inhibition	inhibition	NOUN
gs-4062	435	2	of	of	ADP
gs-4062	435	3	viral	viral	ADJ
gs-4062	435	4	maturation	maturation	NOUN
gs-4062	435	5	(	(	PUNCT
gs-4062	435	6	protease	protease	NOUN
gs-4062	435	7	inhibitors	inhibitor	NOUN
gs-4062	435	8	):	):	PUNCT
gs-4062	435	9	hiv	hiv	PROPN
gs-4062	435	10	protease	protease	NOUN
gs-4062	435	11	is	be	AUX
gs-4062	435	12	an	an	DET
gs-4062	435	13	aspartyl	aspartyl	NOUN
gs-4062	435	14	protease	protease	NOUN
gs-4062	435	15	that	that	PRON
gs-4062	435	16	functions	function	NOUN
gs-4062	435	17	as	as	ADP
gs-4062	435	18	a	a	DET
gs-4062	435	19	homodimer	homodimer	NOUN
gs-4062	435	20	.	.	PUNCT
gs-4062	436	1	pis	pis	PROPN
gs-4062	436	2	are	be	AUX
gs-4062	436	3	designed	design	VERB
gs-4062	436	4	to	to	PART
gs-4062	436	5	mimic	mimic	VERB
gs-4062	436	6	the	the	DET
gs-4062	436	7	transition	transition	NOUN
gs-4062	436	8	state	state	NOUN
gs-4062	436	9	of	of	ADP
gs-4062	436	10	the	the	DET
gs-4062	436	11	peptide	peptide	NOUN
gs-4062	436	12	substrate	substrate	NOUN
gs-4062	436	13	that	that	SCONJ
gs-4062	436	14	the	the	DET
gs-4062	436	15	protease	protease	NOUN
gs-4062	436	16	normally	normally	ADV
gs-4062	436	17	cleaves	cleave	VERB
gs-4062	436	18	.	.	PUNCT
gs-4062	437	1	they	they	PRON
gs-4062	437	2	bind	bind	VERB
gs-4062	437	3	to	to	ADP
gs-4062	437	4	the	the	DET
gs-4062	437	5	enzyme	enzyme	NOUN
gs-4062	437	6	's	's	PART
gs-4062	437	7	active	active	ADJ
gs-4062	437	8	site	site	NOUN
gs-4062	437	9	with	with	ADP
gs-4062	437	10	very	very	ADV
gs-4062	437	11	high	high	ADJ
gs-4062	437	12	affinity	affinity	NOUN
gs-4062	437	13	,	,	PUNCT
gs-4062	437	14	acting	act	VERB
gs-4062	437	15	as	as	ADP
gs-4062	437	16	competitive	competitive	ADJ
gs-4062	437	17	inhibitors	inhibitor	NOUN
gs-4062	437	18	.	.	PUNCT
gs-4062	438	1	this	this	DET
gs-4062	438	2	blockade	blockade	NOUN
gs-4062	438	3	prevents	prevent	VERB
gs-4062	438	4	the	the	DET
gs-4062	438	5	cleavage	cleavage	NOUN
gs-4062	438	6	of	of	ADP
gs-4062	438	7	the	the	DET
gs-4062	438	8	gag	gag	NOUN
gs-4062	438	9	and	and	CCONJ
gs-4062	438	10	gag	gag	NOUN
gs-4062	438	11	-	-	PUNCT
gs-4062	438	12	pol	pol	NOUN
gs-4062	438	13	polyproteins	polyprotein	NOUN
gs-4062	438	14	.	.	PUNCT
gs-4062	439	1	consequently	consequently	ADV
gs-4062	439	2	,	,	PUNCT
gs-4062	439	3	new	new	ADJ
gs-4062	439	4	virions	virion	NOUN
gs-4062	439	5	bud	bud	NOUN
gs-4062	439	6	from	from	ADP
gs-4062	439	7	the	the	DET
gs-4062	439	8	infected	infected	ADJ
gs-4062	439	9	cell	cell	NOUN
gs-4062	439	10	but	but	CCONJ
gs-4062	439	11	are	be	AUX
gs-4062	439	12	structurally	structurally	ADV
gs-4062	439	13	disorganized	disorganized	ADJ
gs-4062	439	14	and	and	CCONJ
gs-4062	439	15	non	non	ADJ
gs-4062	439	16	-	-	ADJ
gs-4062	439	17	infectious	infectious	ADJ
gs-4062	439	18	,	,	PUNCT
gs-4062	439	19	as	as	SCONJ
gs-4062	439	20	core	core	ADJ
gs-4062	439	21	proteins	protein	NOUN
gs-4062	439	22	remain	remain	VERB
gs-4062	439	23	immature	immature	ADJ
gs-4062	439	24	and	and	CCONJ
gs-4062	439	25	unprocessed	unprocessed	ADJ
gs-4062	439	26	.	.	PUNCT
gs-4062	440	1	inhibition	inhibition	NOUN
gs-4062	440	2	of	of	ADP
gs-4062	440	3	integration	integration	NOUN
gs-4062	440	4	(	(	PUNCT
gs-4062	440	5	integrase	integrase	NOUN
gs-4062	440	6	strand	strand	NOUN
gs-4062	440	7	transfer	transfer	NOUN
gs-4062	440	8	inhibitors	inhibitor	NOUN
gs-4062	440	9	):	):	PUNCT
gs-4062	440	10	hiv	hiv	PROPN
gs-4062	440	11	integrase	integrase	NOUN
gs-4062	440	12	performs	perform	VERB
gs-4062	440	13	a	a	DET
gs-4062	440	14	twostep	twostep	NOUN
gs-4062	440	15	reaction	reaction	NOUN
gs-4062	440	16	:	:	PUNCT
gs-4062	440	17	1	1	NUM
gs-4062	440	18	)	)	PUNCT
gs-4062	440	19	3'-processing	3'-processing	NOUN
gs-4062	440	20	,	,	PUNCT
gs-4062	440	21	where	where	SCONJ
gs-4062	440	22	it	it	PRON
gs-4062	440	23	removes	remove	VERB
gs-4062	440	24	a	a	DET
gs-4062	440	25	dinucleotide	dinucleotide	NOUN
gs-4062	440	26	from	from	ADP
gs-4062	440	27	each	each	DET
gs-4062	440	28	3	3	NUM
gs-4062	440	29	'	'	PART
gs-4062	440	30	end	end	NOUN
gs-4062	440	31	of	of	ADP
gs-4062	440	32	the	the	DET
gs-4062	440	33	viral	viral	ADJ
gs-4062	440	34	dna	dna	NOUN
gs-4062	440	35	,	,	PUNCT
gs-4062	440	36	and	and	CCONJ
gs-4062	440	37	2	2	X
gs-4062	440	38	)	)	PUNCT
gs-4062	440	39	strand	strand	NOUN
gs-4062	440	40	transfer	transfer	NOUN
gs-4062	440	41	,	,	PUNCT
gs-4062	440	42	where	where	SCONJ
gs-4062	440	43	it	it	PRON
gs-4062	440	44	covalently	covalently	ADV
gs-4062	440	45	inserts	insert	VERB
gs-4062	440	46	these	these	DET
gs-4062	440	47	processed	process	VERB
gs-4062	440	48	ends	end	NOUN
gs-4062	440	49	into	into	ADP
gs-4062	440	50	the	the	DET
gs-4062	440	51	host	host	NOUN
gs-4062	440	52	genome	genome	NOUN
gs-4062	440	53	.	.	PUNCT
gs-4062	441	1	instis	insti	NOUN
gs-4062	441	2	are	be	AUX
gs-4062	441	3	structurally	structurally	ADV
gs-4062	441	4	analogous	analogous	ADJ
gs-4062	441	5	to	to	ADP
gs-4062	441	6	the	the	DET
gs-4062	441	7	viral	viral	ADJ
gs-4062	441	8	dna	dna	NOUN
gs-4062	441	9	ends	end	VERB
gs-4062	441	10	and	and	CCONJ
gs-4062	441	11	chelate	chelate	VERB
gs-4062	441	12	the	the	DET
gs-4062	441	13	divalent	divalent	ADJ
gs-4062	441	14	metal	metal	NOUN
gs-4062	441	15	ions	ion	NOUN
gs-4062	441	16	(	(	PUNCT
gs-4062	441	17	mg²	mg²	NOUN
gs-4062	441	18	or	or	CCONJ
gs-4062	441	19	mn²	mn²	NOUN
gs-4062	441	20	)	)	PUNCT
gs-4062	441	21	in	in	ADP
gs-4062	441	22	the	the	DET
gs-4062	441	23	integrase	integrase	NOUN
gs-4062	441	24	active	active	ADJ
gs-4062	441	25	site	site	NOUN
gs-4062	441	26	.	.	PUNCT
gs-4062	442	1	this	this	DET
gs-4062	442	2	binding	bind	VERB
gs-4062	442	3	selectively	selectively	ADV
gs-4062	442	4	inhibits	inhibit	VERB
gs-4062	442	5	the	the	DET
gs-4062	442	6	strand	strand	NOUN
gs-4062	442	7	transfer	transfer	NOUN
gs-4062	442	8	step	step	NOUN
gs-4062	442	9	,	,	PUNCT
gs-4062	442	10	leaving	leave	VERB
gs-4062	442	11	the	the	DET
gs-4062	442	12	viral	viral	ADJ
gs-4062	442	13	dna	dna	NOUN
gs-4062	442	14	unable	unable	ADJ
gs-4062	442	15	to	to	PART
gs-4062	442	16	integrate	integrate	VERB
gs-4062	442	17	and	and	CCONJ
gs-4062	442	18	vulnerable	vulnerable	ADJ
gs-4062	442	19	to	to	ADP
gs-4062	442	20	degradation	degradation	NOUN
gs-4062	442	21	by	by	ADP
gs-4062	442	22	host	host	NOUN
gs-4062	442	23	cell	cell	NOUN
gs-4062	442	24	enzymes	enzyme	NOUN
gs-4062	442	25	.	.	PUNCT
gs-4062	443	1	inhibition	inhibition	NOUN
gs-4062	443	2	of	of	ADP
gs-4062	443	3	viral	viral	ADJ
gs-4062	443	4	entry	entry	NOUN
gs-4062	443	5	(	(	PUNCT
gs-4062	443	6	entry	entry	NOUN
gs-4062	443	7	inhibitors	inhibitor	NOUN
gs-4062	443	8	):	):	PUNCT
gs-4062	443	9	this	this	DET
gs-4062	443	10	class	class	NOUN
gs-4062	443	11	employs	employ	VERB
gs-4062	443	12	diverse	diverse	ADJ
gs-4062	443	13	and	and	CCONJ
gs-4062	443	14	highly	highly	ADV
gs-4062	443	15	specific	specific	ADJ
gs-4062	443	16	mechanisms	mechanism	NOUN
gs-4062	443	17	:	:	PUNCT
gs-4062	443	18	fusion	fusion	NOUN
gs-4062	443	19	inhibitors	inhibitor	NOUN
gs-4062	443	20	(	(	PUNCT
gs-4062	443	21	enfuvirtide	enfuvirtide	ADJ
gs-4062	443	22	):	):	PUNCT
gs-4062	443	23	mimics	mimic	VERB
gs-4062	443	24	the	the	DET
gs-4062	443	25	heptad	heptad	NOUN
gs-4062	443	26	repeat	repeat	NOUN
gs-4062	443	27	region	region	NOUN
gs-4062	443	28	2	2	NUM
gs-4062	443	29	(	(	PUNCT
gs-4062	443	30	hr2	hr2	NOUN
gs-4062	443	31	)	)	PUNCT
gs-4062	443	32	of	of	ADP
gs-4062	443	33	the	the	DET
gs-4062	443	34	viral	viral	ADJ
gs-4062	443	35	gp41	gp41	PROPN
gs-4062	443	36	envelope	envelope	NOUN
gs-4062	443	37	glycoprotein	glycoprotein	NOUN
gs-4062	443	38	.	.	PUNCT
gs-4062	444	1	it	it	PRON
gs-4062	444	2	binds	bind	VERB
gs-4062	444	3	to	to	ADP
gs-4062	444	4	the	the	DET
gs-4062	444	5	hr1	hr1	PROPN
gs-4062	444	6	region	region	NOUN
gs-4062	444	7	on	on	ADP
gs-4062	444	8	gp41	gp41	PROPN
gs-4062	444	9	,	,	PUNCT
gs-4062	444	10	preventing	prevent	VERB
gs-4062	444	11	the	the	DET
gs-4062	444	12	formation	formation	NOUN
gs-4062	444	13	of	of	ADP
gs-4062	444	14	the	the	DET
gs-4062	444	15	sixhelix	sixhelix	ADJ
gs-4062	444	16	bundle	bundle	NOUN
gs-4062	444	17	structure	structure	NOUN
gs-4062	444	18	essential	essential	ADJ
gs-4062	444	19	for	for	ADP
gs-4062	444	20	driving	drive	VERB
gs-4062	444	21	the	the	DET
gs-4062	444	22	fusion	fusion	NOUN
gs-4062	444	23	of	of	ADP
gs-4062	444	24	the	the	DET
gs-4062	444	25	viral	viral	ADJ
gs-4062	444	26	and	and	CCONJ
gs-4062	444	27	cellular	cellular	ADJ
gs-4062	444	28	membranes	membrane	NOUN
gs-4062	444	29	.	.	PUNCT
gs-4062	445	1	ccr5	ccr5	NOUN
gs-4062	445	2	antagonists	antagonist	NOUN
gs-4062	445	3	(	(	PUNCT
gs-4062	445	4	maraviroc	maraviroc	NOUN
gs-4062	445	5	):	):	PUNCT
gs-4062	445	6	binds	bind	VERB
gs-4062	445	7	specifically	specifically	ADV
gs-4062	445	8	to	to	ADP
gs-4062	445	9	the	the	DET
gs-4062	445	10	human	human	ADJ
gs-4062	445	11	ccr5	ccr5	PROPN
gs-4062	445	12	coreceptor	coreceptor	NOUN
gs-4062	445	13	,	,	PUNCT
gs-4062	445	14	inducing	induce	VERB
gs-4062	445	15	a	a	DET
gs-4062	445	16	conformational	conformational	ADJ
gs-4062	445	17	change	change	NOUN
gs-4062	445	18	that	that	PRON
gs-4062	445	19	blocks	block	VERB
gs-4062	445	20	its	its	PRON
gs-4062	445	21	interaction	interaction	NOUN
gs-4062	445	22	with	with	ADP
gs-4062	445	23	the	the	DET
gs-4062	445	24	viral	viral	ADJ
gs-4062	445	25	envelope	envelope	NOUN
gs-4062	445	26	gp120	gp120	NOUN
gs-4062	445	27	protein	protein	NOUN
gs-4062	445	28	.	.	PUNCT
gs-4062	446	1	this	this	PRON
gs-4062	446	2	prevents	prevent	VERB
gs-4062	446	3	the	the	DET
gs-4062	446	4	necessary	necessary	ADJ
gs-4062	446	5	engagement	engagement	NOUN
gs-4062	446	6	for	for	ADP
gs-4062	446	7	entry	entry	NOUN
gs-4062	446	8	.	.	PUNCT
gs-4062	447	1	it	it	PRON
gs-4062	447	2	is	be	AUX
gs-4062	447	3	ineffective	ineffective	ADJ
gs-4062	447	4	against	against	ADP
gs-4062	447	5	cxcr4	cxcr4	NOUN
gs-4062	447	6	-	-	PUNCT
gs-4062	447	7	tropic	tropic	ADJ
gs-4062	447	8	or	or	CCONJ
gs-4062	447	9	dualtropic	dualtropic	ADJ
gs-4062	447	10	viruses	virus	NOUN
gs-4062	447	11	.	.	PUNCT
gs-4062	448	1	post	post	ADJ
gs-4062	448	2	-	-	ADJ
gs-4062	448	3	attachment	attachment	ADJ
gs-4062	448	4	inhibitors	inhibitor	NOUN
gs-4062	448	5	(	(	PUNCT
gs-4062	448	6	ibalizumab	ibalizumab	X
gs-4062	448	7	):	):	PUNCT
gs-4062	448	8	a	a	DET
gs-4062	448	9	recombinant	recombinant	ADJ
gs-4062	448	10	monoclonal	monoclonal	NOUN
gs-4062	448	11	antibody	antibody	NOUN
gs-4062	448	12	that	that	PRON
gs-4062	448	13	binds	bind	VERB
gs-4062	448	14	to	to	PART
gs-4062	448	15	domain	domain	VERB
gs-4062	448	16	2	2	NUM
gs-4062	448	17	of	of	ADP
gs-4062	448	18	the	the	DET
gs-4062	448	19	cd4	cd4	PROPN
gs-4062	448	20	receptor	receptor	NOUN
gs-4062	448	21	.	.	PUNCT
gs-4062	449	1	this	this	DET
gs-4062	449	2	binding	binding	NOUN
gs-4062	449	3	does	do	AUX
gs-4062	449	4	not	not	PART
gs-4062	449	5	block	block	VERB
gs-4062	449	6	hiv	hiv	PROPN
gs-4062	449	7	attachment	attachment	NOUN
gs-4062	449	8	but	but	CCONJ
gs-4062	449	9	induces	induce	VERB
gs-4062	449	10	conformational	conformational	ADJ
gs-4062	449	11	changes	change	NOUN
gs-4062	449	12	in	in	ADP
gs-4062	449	13	the	the	DET
gs-4062	449	14	receptor	receptor	NOUN
gs-4062	449	15	that	that	PRON
gs-4062	449	16	prevent	prevent	VERB
gs-4062	449	17	the	the	DET
gs-4062	449	18	viral	viral	ADJ
gs-4062	449	19	envelope	envelope	NOUN
gs-4062	449	20	from	from	ADP
gs-4062	449	21	undergoing	undergo	VERB
gs-4062	449	22	the	the	DET
gs-4062	449	23	necessary	necessary	ADJ
gs-4062	449	24	rearrangements	rearrangement	NOUN
gs-4062	449	25	for	for	ADP
gs-4062	449	26	fusion	fusion	NOUN
gs-4062	449	27	,	,	PUNCT
gs-4062	449	28	specifically	specifically	ADV
gs-4062	449	29	hindering	hinder	VERB
gs-4062	449	30	the	the	DET
gs-4062	449	31	transition	transition	NOUN
gs-4062	449	32	from	from	ADP
gs-4062	449	33	a	a	DET
gs-4062	449	34	cd4	cd4	PROPN
gs-4062	449	35	-	-	PUNCT
gs-4062	449	36	bound	bind	VERB
gs-4062	449	37	to	to	ADP
gs-4062	449	38	a	a	DET
gs-4062	449	39	coreceptor	coreceptor	NOUN
gs-4062	449	40	-	-	PUNCT
gs-4062	449	41	bound	bind	VERB
gs-4062	449	42	state	state	NOUN
gs-4062	449	43	.	.	PUNCT
gs-4062	450	1	attachment	attachment	NOUN
gs-4062	450	2	inhibitors	inhibitor	NOUN
gs-4062	450	3	(	(	PUNCT
gs-4062	450	4	fostemsavir	fostemsavir	PROPN
gs-4062	450	5	):	):	PUNCT
gs-4062	450	6	a	a	DET
gs-4062	450	7	prodrug	prodrug	NOUN
gs-4062	450	8	hydrolyzed	hydrolyze	VERB
gs-4062	450	9	to	to	ADP
gs-4062	450	10	its	its	PRON
gs-4062	450	11	active	active	ADJ
gs-4062	450	12	form	form	NOUN
gs-4062	450	13	,	,	PUNCT
gs-4062	450	14	temsavir	temsavir	PROPN
gs-4062	450	15	.	.	PUNCT
gs-4062	451	1	temsavir	temsavir	PROPN
gs-4062	451	2	binds	bind	VERB
gs-4062	451	3	directly	directly	ADV
gs-4062	451	4	to	to	ADP
gs-4062	451	5	the	the	DET
gs-4062	451	6	gp120	gp120	ADJ
gs-4062	451	7	subunit	subunit	NOUN
gs-4062	451	8	of	of	ADP
gs-4062	451	9	the	the	DET
gs-4062	451	10	viral	viral	ADJ
gs-4062	451	11	envelope	envelope	NOUN
gs-4062	451	12	,	,	PUNCT
gs-4062	451	13	stabilizing	stabilize	VERB
gs-4062	451	14	it	it	PRON
gs-4062	451	15	in	in	ADP
gs-4062	451	16	a	a	DET
gs-4062	451	17	conformation	conformation	NOUN
gs-4062	451	18	that	that	PRON
gs-4062	451	19	prevents	prevent	VERB
gs-4062	451	20	the	the	DET
gs-4062	451	21	initial	initial	ADJ
gs-4062	451	22	interaction	interaction	NOUN
gs-4062	451	23	with	with	ADP
gs-4062	451	24	the	the	DET
gs-4062	451	25	cd4	cd4	PROPN
gs-4062	451	26	receptor	receptor	NOUN
gs-4062	451	27	,	,	PUNCT
gs-4062	451	28	thereby	thereby	ADV
gs-4062	451	29	blocking	block	VERB
gs-4062	451	30	the	the	DET
gs-4062	451	31	very	very	ADV
gs-4062	451	32	first	first	ADJ
gs-4062	451	33	step	step	NOUN
gs-4062	451	34	of	of	ADP
gs-4062	451	35	viral	viral	ADJ
gs-4062	451	36	entry	entry	NOUN
gs-4062	451	37	.	.	PUNCT
gs-4062	452	1	georgian	georgian	NOUN
gs-4062	452	2	scientists/	scientists/	NUM
gs-4062	452	3	.	.	PUNCT
gs-4062	453	1	7	7	NUM
gs-4062	453	2	n	n	PRON
gs-4062	453	3	3	3	NUM
gs-4062	453	4	,	,	PUNCT
gs-4062	453	5	2025	2025	NUM
gs-4062	453	6	542	542	NUM
gs-4062	453	7	clinical	clinical	ADJ
gs-4062	453	8	use	use	NOUN
gs-4062	453	9	and	and	CCONJ
gs-4062	453	10	guidelines	guideline	NOUN
gs-4062	453	11	:	:	PUNCT
gs-4062	453	12	from	from	ADP
gs-4062	453	13	first	first	ADJ
gs-4062	453	14	-	-	PUNCT
gs-4062	453	15	line	line	NOUN
gs-4062	453	16	to	to	PART
gs-4062	453	17	salvage	salvage	NOUN
gs-4062	453	18	therapy	therapy	NOUN
gs-4062	453	19	the	the	DET
gs-4062	453	20	scientific	scientific	ADJ
gs-4062	453	21	discussion	discussion	NOUN
gs-4062	453	22	around	around	ADP
gs-4062	453	23	art	art	NOUN
gs-4062	453	24	is	be	AUX
gs-4062	453	25	codified	codify	VERB
gs-4062	453	26	in	in	ADP
gs-4062	453	27	regularly	regularly	ADV
gs-4062	453	28	updated	update	VERB
gs-4062	453	29	treatment	treatment	NOUN
gs-4062	453	30	guidelines	guideline	NOUN
gs-4062	453	31	,	,	PUNCT
gs-4062	453	32	most	most	ADV
gs-4062	453	33	notably	notably	ADV
gs-4062	453	34	those	those	PRON
gs-4062	453	35	from	from	ADP
gs-4062	453	36	the	the	DET
gs-4062	453	37	u.s	u.s	PROPN
gs-4062	453	38	.	.	PROPN
gs-4062	453	39	department	department	PROPN
gs-4062	453	40	of	of	ADP
gs-4062	453	41	health	health	PROPN
gs-4062	453	42	and	and	CCONJ
gs-4062	453	43	human	human	PROPN
gs-4062	453	44	services	service	NOUN
gs-4062	453	45	(	(	PUNCT
gs-4062	453	46	dhhs	dhhs	PROPN
gs-4062	453	47	)	)	PUNCT
gs-4062	453	48	and	and	CCONJ
gs-4062	453	49	the	the	DET
gs-4062	453	50	international	international	ADJ
gs-4062	453	51	antiviral	antiviral	ADJ
gs-4062	453	52	society	society	PROPN
gs-4062	453	53	-	-	PUNCT
gs-4062	453	54	usa	usa	PROPN
gs-4062	453	55	(	(	PUNCT
gs-4062	453	56	ias	ias	PROPN
gs-4062	453	57	-	-	PUNCT
gs-4062	453	58	usa	usa	NOUN
gs-4062	453	59	)	)	PUNCT
gs-4062	453	60	.	.	PUNCT
gs-4062	454	1	the	the	DET
gs-4062	454	2	overarching	overarching	ADJ
gs-4062	454	3	goals	goal	NOUN
gs-4062	454	4	of	of	ADP
gs-4062	454	5	therapy	therapy	NOUN
gs-4062	454	6	are	be	AUX
gs-4062	454	7	to	to	PART
gs-4062	454	8	achieve	achieve	VERB
gs-4062	454	9	and	and	CCONJ
gs-4062	454	10	maintain	maintain	VERB
gs-4062	454	11	durable	durable	ADJ
gs-4062	454	12	viral	viral	ADJ
gs-4062	454	13	suppression	suppression	NOUN
gs-4062	454	14	(	(	PUNCT
gs-4062	454	15	plasma	plasma	NOUN
gs-4062	454	16	hiv	hiv	PROPN
gs-4062	454	17	rna	rna	PROPN
gs-4062	454	18	<	<	X
gs-4062	454	19	50	50	NUM
gs-4062	454	20	copies	copy	NOUN
gs-4062	454	21	/	/	SYM
gs-4062	454	22	ml	ml	NOUN
gs-4062	454	23	)	)	PUNCT
gs-4062	454	24	,	,	PUNCT
gs-4062	454	25	restore	restore	VERB
gs-4062	454	26	and	and	CCONJ
gs-4062	454	27	preserve	preserve	VERB
gs-4062	454	28	immune	immune	ADJ
gs-4062	454	29	function	function	NOUN
gs-4062	454	30	,	,	PUNCT
gs-4062	454	31	reduce	reduce	VERB
gs-4062	454	32	hiv	hiv	PROPN
gs-4062	454	33	-	-	PUNCT
gs-4062	454	34	associated	associate	VERB
gs-4062	454	35	morbidity	morbidity	NOUN
gs-4062	454	36	and	and	CCONJ
gs-4062	454	37	mortality	mortality	NOUN
gs-4062	454	38	,	,	PUNCT
gs-4062	454	39	and	and	CCONJ
gs-4062	454	40	prevent	prevent	VERB
gs-4062	454	41	hiv	hiv	PROPN
gs-4062	454	42	transmission	transmission	NOUN
gs-4062	454	43	.	.	PUNCT
gs-4062	455	1	initial	initial	ADJ
gs-4062	455	2	therapy	therapy	NOUN
gs-4062	455	3	for	for	ADP
gs-4062	455	4	antiretroviral	antiretroviral	ADJ
gs-4062	455	5	-	-	PUNCT
gs-4062	455	6	naïve	naïve	ADJ
gs-4062	455	7	patients	patient	NOUN
gs-4062	455	8	:	:	PUNCT
gs-4062	455	9	the	the	DET
gs-4062	455	10	current	current	ADJ
gs-4062	455	11	universal	universal	ADJ
gs-4062	455	12	recommendation	recommendation	NOUN
gs-4062	455	13	is	be	AUX
gs-4062	455	14	to	to	PART
gs-4062	455	15	initiate	initiate	VERB
gs-4062	455	16	art	art	NOUN
gs-4062	455	17	at	at	ADP
gs-4062	455	18	the	the	DET
gs-4062	455	19	time	time	NOUN
gs-4062	455	20	of	of	ADP
gs-4062	455	21	diagnosis	diagnosis	NOUN
gs-4062	455	22	,	,	PUNCT
gs-4062	455	23	regardless	regardless	ADV
gs-4062	455	24	of	of	ADP
gs-4062	455	25	cd4	cd4	PROPN
gs-4062	455	26	count	count	NOUN
gs-4062	455	27	.	.	PUNCT
gs-4062	456	1	the	the	DET
gs-4062	456	2	preferred	preferred	ADJ
gs-4062	456	3	regimens	regimen	NOUN
gs-4062	456	4	for	for	ADP
gs-4062	456	5	most	most	ADJ
gs-4062	456	6	patients	patient	NOUN
gs-4062	456	7	are	be	AUX
gs-4062	456	8	all	all	PRON
gs-4062	456	9	insti	insti	NOUN
gs-4062	456	10	-	-	PUNCT
gs-4062	456	11	based	base	VERB
gs-4062	456	12	due	due	ADP
gs-4062	456	13	to	to	ADP
gs-4062	456	14	their	their	PRON
gs-4062	456	15	rapid	rapid	ADJ
gs-4062	456	16	virologic	virologic	ADJ
gs-4062	456	17	suppression	suppression	NOUN
gs-4062	456	18	,	,	PUNCT
gs-4062	456	19	high	high	ADJ
gs-4062	456	20	barrier	barrier	NOUN
gs-4062	456	21	to	to	ADP
gs-4062	456	22	resistance	resistance	NOUN
gs-4062	456	23	,	,	PUNCT
gs-4062	456	24	and	and	CCONJ
gs-4062	456	25	tolerability	tolerability	NOUN
gs-4062	456	26	.	.	PUNCT
gs-4062	457	1	recommended	recommend	VERB
gs-4062	457	2	regimens	regimen	NOUN
gs-4062	457	3	:	:	PUNCT
gs-4062	457	4	bictegravir	bictegravir	PROPN
gs-4062	457	5	/	/	SYM
gs-4062	457	6	taf	taf	PROPN
gs-4062	457	7	/	/	SYM
gs-4062	457	8	ftc	ftc	PROPN
gs-4062	457	9	(	(	PUNCT
gs-4062	457	10	biktarvy	biktarvy	PROPN
gs-4062	457	11	®	®	PROPN
gs-4062	457	12	):	):	PUNCT
gs-4062	457	13	a	a	DET
gs-4062	457	14	single	single	ADJ
gs-4062	457	15	-	-	PUNCT
gs-4062	457	16	tablet	tablet	NOUN
gs-4062	457	17	regimen	regiman	NOUN
gs-4062	457	18	(	(	PUNCT
gs-4062	457	19	str	str	NOUN
gs-4062	457	20	)	)	PUNCT
gs-4062	457	21	with	with	ADP
gs-4062	457	22	high	high	ADJ
gs-4062	457	23	efficacy	efficacy	NOUN
gs-4062	457	24	,	,	PUNCT
gs-4062	457	25	a	a	DET
gs-4062	457	26	high	high	ADJ
gs-4062	457	27	barrier	barrier	NOUN
gs-4062	457	28	to	to	ADP
gs-4062	457	29	resistance	resistance	NOUN
gs-4062	457	30	,	,	PUNCT
gs-4062	457	31	and	and	CCONJ
gs-4062	457	32	no	no	DET
gs-4062	457	33	need	need	NOUN
gs-4062	457	34	for	for	ADP
gs-4062	457	35	hla	hla	NOUN
gs-4062	457	36	-	-	PUNCT
gs-4062	457	37	b*5701	b*5701	NOUN
gs-4062	457	38	testing	testing	NOUN
gs-4062	457	39	(	(	PUNCT
gs-4062	457	40	unlike	unlike	ADP
gs-4062	457	41	abc	abc	PROPN
gs-4062	457	42	)	)	PUNCT
gs-4062	457	43	.	.	PUNCT
gs-4062	458	1	it	it	PRON
gs-4062	458	2	is	be	AUX
gs-4062	458	3	a	a	DET
gs-4062	458	4	first	first	ADJ
gs-4062	458	5	-	-	PUNCT
gs-4062	458	6	line	line	NOUN
gs-4062	458	7	choice	choice	NOUN
gs-4062	458	8	for	for	ADP
gs-4062	458	9	most	most	ADJ
gs-4062	458	10	.	.	PUNCT
gs-4062	459	1	dolutegravir	dolutegravir	NOUN
gs-4062	459	2	/	/	SYM
gs-4062	459	3	taf(or	taf(or	NOUN
gs-4062	459	4	tdf)/ftc	tdf)/ftc	PROPN
gs-4062	459	5	:	:	PUNCT
gs-4062	459	6	dtg	dtg	PROPN
gs-4062	459	7	is	be	AUX
gs-4062	459	8	a	a	DET
gs-4062	459	9	potent	potent	ADJ
gs-4062	459	10	insti	insti	NOUN
gs-4062	459	11	with	with	ADP
gs-4062	459	12	a	a	DET
gs-4062	459	13	high	high	ADJ
gs-4062	459	14	genetic	genetic	ADJ
gs-4062	459	15	barrier	barrier	NOUN
gs-4062	459	16	.	.	PUNCT
gs-4062	460	1	it	it	PRON
gs-4062	460	2	can	can	AUX
gs-4062	460	3	be	be	AUX
gs-4062	460	4	combined	combine	VERB
gs-4062	460	5	with	with	ADP
gs-4062	460	6	descovy	descovy	NOUN
gs-4062	460	7	®	®	NOUN
gs-4062	460	8	(	(	PUNCT
gs-4062	460	9	taf	taf	X
gs-4062	460	10	/	/	SYM
gs-4062	460	11	ftc	ftc	PROPN
gs-4062	460	12	)	)	PUNCT
gs-4062	460	13	or	or	CCONJ
gs-4062	460	14	truvada	truvada	PROPN
gs-4062	460	15	®	®	NOUN
gs-4062	460	16	(	(	PUNCT
gs-4062	460	17	tdf	tdf	PROPN
gs-4062	460	18	/	/	SYM
gs-4062	460	19	ftc	ftc	PROPN
gs-4062	460	20	)	)	PUNCT
gs-4062	460	21	.	.	PUNCT
gs-4062	461	1	a	a	DET
gs-4062	461	2	popular	popular	ADJ
gs-4062	461	3	global	global	ADJ
gs-4062	461	4	option	option	NOUN
gs-4062	461	5	,	,	PUNCT
gs-4062	461	6	especially	especially	ADV
gs-4062	461	7	with	with	ADP
gs-4062	461	8	the	the	DET
gs-4062	461	9	availability	availability	NOUN
gs-4062	461	10	of	of	ADP
gs-4062	461	11	generic	generic	PROPN
gs-4062	461	12	dtg	dtg	PROPN
gs-4062	461	13	.	.	PROPN
gs-4062	461	14	dolutegravir/	dolutegravir/	NUM
gs-4062	461	15	lamivudine	lamivudine	NOUN
gs-4062	461	16	(	(	PUNCT
gs-4062	461	17	dovato	dovato	PROPN
gs-4062	461	18	®	®	PROPN
gs-4062	461	19	):	):	PUNCT
gs-4062	461	20	a	a	DET
gs-4062	461	21	two	two	NUM
gs-4062	461	22	-	-	PUNCT
gs-4062	461	23	drug	drug	NOUN
gs-4062	461	24	regimen	regiman	NOUN
gs-4062	461	25	(	(	PUNCT
gs-4062	461	26	2dr	2dr	ADJ
gs-4062	461	27	)	)	PUNCT
gs-4062	461	28	demonstrated	demonstrate	VERB
gs-4062	461	29	to	to	PART
gs-4062	461	30	be	be	AUX
gs-4062	461	31	noninferior	noninferior	ADJ
gs-4062	461	32	to	to	ADP
gs-4062	461	33	three	three	NUM
gs-4062	461	34	-	-	PUNCT
gs-4062	461	35	drug	drug	NOUN
gs-4062	461	36	regimens	regimen	NOUN
gs-4062	461	37	in	in	ADP
gs-4062	461	38	art	art	NOUN
gs-4062	461	39	-	-	PUNCT
gs-4062	461	40	naïve	naïve	ADJ
gs-4062	461	41	patients	patient	NOUN
gs-4062	461	42	.	.	PUNCT
gs-4062	462	1	it	it	PRON
gs-4062	462	2	simplifies	simplify	VERB
gs-4062	462	3	therapy	therapy	NOUN
gs-4062	462	4	,	,	PUNCT
gs-4062	462	5	reduces	reduce	VERB
gs-4062	462	6	long	long	ADJ
gs-4062	462	7	-	-	PUNCT
gs-4062	462	8	term	term	NOUN
gs-4062	462	9	drug	drug	NOUN
gs-4062	462	10	exposure	exposure	NOUN
gs-4062	462	11	,	,	PUNCT
gs-4062	462	12	and	and	CCONJ
gs-4062	462	13	is	be	AUX
gs-4062	462	14	a	a	DET
gs-4062	462	15	key	key	ADJ
gs-4062	462	16	option	option	NOUN
gs-4062	462	17	for	for	ADP
gs-4062	462	18	those	those	PRON
gs-4062	462	19	without	without	ADP
gs-4062	462	20	baseline	baseline	ADJ
gs-4062	462	21	resistance	resistance	NOUN
gs-4062	462	22	to	to	ADP
gs-4062	462	23	either	either	DET
gs-4062	462	24	component	component	NOUN
gs-4062	462	25	.	.	PUNCT
gs-4062	463	1	alternative	alternative	ADJ
gs-4062	463	2	regimens	regimen	NOUN
gs-4062	463	3	:	:	PUNCT
gs-4062	463	4	include	include	AUX
gs-4062	463	5	boosted	boost	VERB
gs-4062	463	6	pi	pi	ADV
gs-4062	463	7	-	-	PUNCT
gs-4062	463	8	based	base	VERB
gs-4062	463	9	regimens	regimen	NOUN
gs-4062	463	10	(	(	PUNCT
gs-4062	463	11	e.g.	e.g.	ADV
gs-4062	463	12	,	,	PUNCT
gs-4062	463	13	drv	drv	X
gs-4062	463	14	/	/	SYM
gs-4062	463	15	cobi	cobi	PROPN
gs-4062	463	16	/	/	SYM
gs-4062	463	17	taf	taf	PROPN
gs-4062	463	18	/	/	SYM
gs-4062	463	19	ftc	ftc	PROPN
gs-4062	463	20	)	)	PUNCT
gs-4062	463	21	or	or	CCONJ
gs-4062	463	22	the	the	DET
gs-4062	463	23	newer	new	ADJ
gs-4062	463	24	nnrti	nnrti	NOUN
gs-4062	463	25	doravirine	doravirine	ADV
gs-4062	463	26	-	-	PUNCT
gs-4062	463	27	based	base	VERB
gs-4062	463	28	regimens	regimen	NOUN
gs-4062	463	29	(	(	PUNCT
gs-4062	463	30	doravirine	doravirine	ADJ
gs-4062	463	31	/	/	SYM
gs-4062	463	32	taf	taf	PROPN
gs-4062	463	33	/	/	SYM
gs-4062	463	34	ftc	ftc	PROPN
gs-4062	463	35	or	or	CCONJ
gs-4062	463	36	doravirine	doravirine	ADJ
gs-4062	463	37	/	/	SYM
gs-4062	463	38	tdf/3tc	tdf/3tc	NOUN
gs-4062	463	39	)	)	PUNCT
gs-4062	463	40	.	.	PUNCT
gs-4062	464	1	management	management	NOUN
gs-4062	464	2	of	of	ADP
gs-4062	464	3	multidrug	multidrug	NOUN
gs-4062	464	4	-	-	PUNCT
gs-4062	464	5	resistant	resistant	ADJ
gs-4062	464	6	(	(	PUNCT
gs-4062	464	7	mdr	mdr	PROPN
gs-4062	464	8	)	)	PUNCT
gs-4062	464	9	hiv	hiv	PROPN
gs-4062	464	10	:	:	PUNCT
gs-4062	464	11	for	for	ADP
gs-4062	464	12	patients	patient	NOUN
gs-4062	464	13	with	with	ADP
gs-4062	464	14	complex	complex	ADJ
gs-4062	464	15	treatment	treatment	NOUN
gs-4062	464	16	histories	history	NOUN
gs-4062	464	17	and	and	CCONJ
gs-4062	464	18	resistance	resistance	NOUN
gs-4062	464	19	to	to	ADP
gs-4062	464	20	multiple	multiple	ADJ
gs-4062	464	21	drug	drug	NOUN
gs-4062	464	22	classes	class	NOUN
gs-4062	464	23	,	,	PUNCT
gs-4062	464	24	constructing	construct	VERB
gs-4062	464	25	a	a	DET
gs-4062	464	26	viable	viable	ADJ
gs-4062	464	27	regimen	regimen	NOUN
gs-4062	464	28	requires	require	VERB
gs-4062	464	29	genotypic	genotypic	ADJ
gs-4062	464	30	resistance	resistance	NOUN
gs-4062	464	31	testing	testing	NOUN
gs-4062	464	32	and	and	CCONJ
gs-4062	464	33	expert	expert	NOUN
gs-4062	464	34	advice	advice	NOUN
gs-4062	464	35	.	.	PUNCT
gs-4062	465	1	newer	new	ADJ
gs-4062	465	2	agents	agent	NOUN
gs-4062	465	3	have	have	AUX
gs-4062	465	4	revolutionized	revolutionize	VERB
gs-4062	465	5	salvage	salvage	NOUN
gs-4062	465	6	therapy	therapy	NOUN
gs-4062	465	7	.	.	PUNCT
gs-4062	466	1	ibalizumab	ibalizumab	PROPN
gs-4062	466	2	:	:	PUNCT
gs-4062	466	3	administered	administer	VERB
gs-4062	466	4	intravenously	intravenously	ADV
gs-4062	466	5	every	every	DET
gs-4062	466	6	two	two	NUM
gs-4062	466	7	weeks	week	NOUN
gs-4062	466	8	,	,	PUNCT
gs-4062	466	9	it	it	PRON
gs-4062	466	10	is	be	AUX
gs-4062	466	11	active	active	ADJ
gs-4062	466	12	against	against	ADP
gs-4062	466	13	virus	virus	NOUN
gs-4062	466	14	resistant	resistant	ADJ
gs-4062	466	15	to	to	ADP
gs-4062	466	16	other	other	ADJ
gs-4062	466	17	classes	class	NOUN
gs-4062	466	18	due	due	ADP
gs-4062	466	19	to	to	ADP
gs-4062	466	20	its	its	PRON
gs-4062	466	21	unique	unique	ADJ
gs-4062	466	22	host	host	NOUN
gs-4062	466	23	-	-	PUNCT
gs-4062	466	24	targeted	target	VERB
gs-4062	466	25	mechanism	mechanism	NOUN
gs-4062	466	26	.	.	PUNCT
gs-4062	467	1	it	it	PRON
gs-4062	467	2	is	be	AUX
gs-4062	467	3	a	a	DET
gs-4062	467	4	crucial	crucial	ADJ
gs-4062	467	5	addition	addition	NOUN
gs-4062	467	6	for	for	ADP
gs-4062	467	7	constructing	construct	VERB
gs-4062	467	8	a	a	DET
gs-4062	467	9	new	new	ADJ
gs-4062	467	10	regimen	regimen	NOUN
gs-4062	467	11	for	for	ADP
gs-4062	467	12	mdr	mdr	PROPN
gs-4062	467	13	hiv	hiv	PROPN
gs-4062	467	14	.	.	PUNCT
gs-4062	468	1	fostemsavir	fostemsavir	PROPN
gs-4062	468	2	:	:	PUNCT
gs-4062	468	3	used	use	VERB
gs-4062	468	4	twice	twice	ADV
gs-4062	468	5	daily	daily	ADV
gs-4062	468	6	in	in	ADP
gs-4062	468	7	combination	combination	NOUN
gs-4062	468	8	with	with	ADP
gs-4062	468	9	other	other	ADJ
gs-4062	468	10	antiretrovirals	antiretroviral	NOUN
gs-4062	468	11	,	,	PUNCT
gs-4062	468	12	it	it	PRON
gs-4062	468	13	provides	provide	VERB
gs-4062	468	14	a	a	DET
gs-4062	468	15	new	new	ADJ
gs-4062	468	16	mechanism	mechanism	NOUN
gs-4062	468	17	of	of	ADP
gs-4062	468	18	action	action	NOUN
gs-4062	468	19	to	to	PART
gs-4062	468	20	overcome	overcome	VERB
gs-4062	468	21	resistance	resistance	NOUN
gs-4062	468	22	in	in	ADP
gs-4062	468	23	heavily	heavily	ADV
gs-4062	468	24	treatment	treatment	NOUN
gs-4062	468	25	-	-	PUNCT
gs-4062	468	26	experienced	experience	VERB
gs-4062	468	27	adults	adult	NOUN
gs-4062	468	28	with	with	ADP
gs-4062	468	29	limited	limited	ADJ
gs-4062	468	30	treatment	treatment	NOUN
gs-4062	468	31	options	option	NOUN
gs-4062	468	32	.	.	PUNCT
gs-4062	469	1	optimized	optimize	VERB
gs-4062	469	2	background	background	NOUN
gs-4062	469	3	regimen	regiman	NOUN
gs-4062	469	4	(	(	PUNCT
gs-4062	469	5	obr	obr	PROPN
gs-4062	469	6	):	):	PUNCT
gs-4062	469	7	these	these	DET
gs-4062	469	8	new	new	ADJ
gs-4062	469	9	agents	agent	NOUN
gs-4062	469	10	are	be	AUX
gs-4062	469	11	never	never	ADV
gs-4062	469	12	used	use	VERB
gs-4062	469	13	alone	alone	ADV
gs-4062	469	14	.	.	PUNCT
gs-4062	470	1	they	they	PRON
gs-4062	470	2	must	must	AUX
gs-4062	470	3	be	be	AUX
gs-4062	470	4	combined	combine	VERB
gs-4062	470	5	with	with	ADP
gs-4062	470	6	at	at	ADV
gs-4062	470	7	least	least	ADV
gs-4062	470	8	one	one	NUM
gs-4062	470	9	,	,	PUNCT
gs-4062	470	10	and	and	CCONJ
gs-4062	470	11	preferably	preferably	ADV
gs-4062	470	12	two	two	NUM
gs-4062	470	13	,	,	PUNCT
gs-4062	470	14	other	other	ADJ
gs-4062	470	15	fully	fully	ADV
gs-4062	470	16	active	active	ADJ
gs-4062	470	17	agents	agent	NOUN
gs-4062	470	18	based	base	VERB
gs-4062	470	19	on	on	ADP
gs-4062	470	20	resistance	resistance	NOUN
gs-4062	470	21	testing	testing	NOUN
gs-4062	470	22	to	to	PART
gs-4062	470	23	form	form	VERB
gs-4062	470	24	a	a	DET
gs-4062	470	25	new	new	ADJ
gs-4062	470	26	suppressive	suppressive	ADJ
gs-4062	470	27	regimen	regiman	NOUN
gs-4062	470	28	.	.	PUNCT
gs-4062	471	1	long	long	ADV
gs-4062	471	2	-	-	PUNCT
gs-4062	471	3	acting	act	VERB
gs-4062	471	4	injectable	injectable	ADJ
gs-4062	471	5	therapy	therapy	NOUN
gs-4062	471	6	:	:	PUNCT
gs-4062	471	7	a	a	DET
gs-4062	471	8	paradigm	paradigm	NOUN
gs-4062	471	9	shift	shift	NOUN
gs-4062	471	10	:	:	PUNCT
gs-4062	472	1	the	the	DET
gs-4062	472	2	most	most	ADV
gs-4062	472	3	significant	significant	ADJ
gs-4062	472	4	recent	recent	ADJ
gs-4062	472	5	advancement	advancement	NOUN
gs-4062	472	6	in	in	ADP
gs-4062	472	7	clinical	clinical	ADJ
gs-4062	472	8	use	use	NOUN
gs-4062	472	9	is	be	AUX
gs-4062	472	10	the	the	DET
gs-4062	472	11	approval	approval	NOUN
gs-4062	472	12	of	of	ADP
gs-4062	472	13	long	long	ADV
gs-4062	472	14	-	-	PUNCT
gs-4062	472	15	acting	act	VERB
gs-4062	472	16	(	(	PUNCT
gs-4062	472	17	la	la	ADJ
gs-4062	472	18	)	)	PUNCT
gs-4062	472	19	injectable	injectable	ADJ
gs-4062	472	20	cabotegravir	cabotegravir	PROPN
gs-4062	472	21	(	(	PUNCT
gs-4062	472	22	cab	cab	NOUN
gs-4062	472	23	)	)	PUNCT
gs-4062	472	24	and	and	CCONJ
gs-4062	472	25	rilpivirine	rilpivirine	VERB
gs-4062	472	26	(	(	PUNCT
gs-4062	472	27	rpv	rpv	NOUN
gs-4062	472	28	)	)	PUNCT
gs-4062	472	29	.	.	PUNCT
gs-4062	473	1	mechanism	mechanism	NOUN
gs-4062	473	2	:	:	PUNCT
gs-4062	473	3	this	this	PRON
gs-4062	473	4	is	be	AUX
gs-4062	473	5	not	not	PART
gs-4062	473	6	a	a	DET
gs-4062	473	7	new	new	ADJ
gs-4062	473	8	class	class	NOUN
gs-4062	473	9	but	but	CCONJ
gs-4062	473	10	a	a	DET
gs-4062	473	11	novel	novel	ADJ
gs-4062	473	12	formulation	formulation	NOUN
gs-4062	473	13	.	.	PUNCT
gs-4062	474	1	cab	cab	NOUN
gs-4062	474	2	is	be	AUX
gs-4062	474	3	an	an	DET
gs-4062	474	4	insti	insti	NOUN
gs-4062	474	5	and	and	CCONJ
gs-4062	474	6	rpv	rpv	NOUN
gs-4062	474	7	is	be	AUX
gs-4062	474	8	an	an	DET
gs-4062	474	9	nnrti	nnrti	NOUN
gs-4062	474	10	,	,	PUNCT
gs-4062	474	11	but	but	CCONJ
gs-4062	474	12	they	they	PRON
gs-4062	474	13	are	be	AUX
gs-4062	474	14	formulated	formulate	VERB
gs-4062	474	15	as	as	ADP
gs-4062	474	16	nanocrystals	nanocrystal	NOUN
gs-4062	474	17	allowing	allow	VERB
gs-4062	474	18	for	for	ADP
gs-4062	474	19	slow	slow	ADJ
gs-4062	474	20	release	release	NOUN
gs-4062	474	21	from	from	ADP
gs-4062	474	22	the	the	DET
gs-4062	474	23	intramuscular	intramuscular	ADJ
gs-4062	474	24	injection	injection	NOUN
gs-4062	474	25	site	site	NOUN
gs-4062	474	26	.	.	PUNCT
gs-4062	475	1	clinical	clinical	ADJ
gs-4062	475	2	use	use	NOUN
gs-4062	475	3	:	:	PUNCT
gs-4062	475	4	approved	approve	VERB
gs-4062	475	5	for	for	ADP
gs-4062	475	6	maintenance	maintenance	NOUN
gs-4062	475	7	therapy	therapy	NOUN
gs-4062	475	8	in	in	ADP
gs-4062	475	9	virologically	virologically	ADV
gs-4062	475	10	suppressed	suppress	VERB
gs-4062	475	11	adults	adult	NOUN
gs-4062	475	12	(	(	PUNCT
gs-4062	475	13	hiv	hiv	PROPN
gs-4062	475	14	rna	rna	PROPN
gs-4062	475	15	<	<	X
gs-4062	475	16	50	50	NUM
gs-4062	475	17	copies	copy	NOUN
gs-4062	475	18	/	/	SYM
gs-4062	475	19	ml	ml	NOUN
gs-4062	475	20	)	)	PUNCT
gs-4062	475	21	with	with	ADP
gs-4062	475	22	no	no	DET
gs-4062	475	23	history	history	NOUN
gs-4062	475	24	of	of	ADP
gs-4062	475	25	treatment	treatment	NOUN
gs-4062	475	26	failure	failure	NOUN
gs-4062	475	27	or	or	CCONJ
gs-4062	475	28	resistance	resistance	NOUN
gs-4062	475	29	to	to	ADP
gs-4062	475	30	either	either	DET
gs-4062	475	31	drug	drug	NOUN
gs-4062	475	32	.	.	PUNCT
gs-4062	476	1	it	it	PRON
gs-4062	476	2	involves	involve	VERB
gs-4062	476	3	an	an	DET
gs-4062	476	4	oral	oral	ADJ
gs-4062	476	5	lead	lead	NOUN
gs-4062	476	6	-	-	PUNCT
gs-4062	476	7	in	in	ADP
gs-4062	476	8	period	period	NOUN
gs-4062	476	9	to	to	PART
gs-4062	476	10	assess	assess	VERB
gs-4062	476	11	tolerability	tolerability	NOUN
gs-4062	476	12	,	,	PUNCT
gs-4062	476	13	followed	follow	VERB
gs-4062	476	14	by	by	ADP
gs-4062	476	15	monthly	monthly	ADJ
gs-4062	476	16	or	or	CCONJ
gs-4062	476	17	every	every	PRON
gs-4062	476	18	-	-	PUNCT
gs-4062	476	19	two	two	NUM
gs-4062	476	20	-	-	PUNCT
gs-4062	476	21	month	month	NOUN
gs-4062	476	22	injections	injection	NOUN
gs-4062	476	23	.	.	PUNCT
gs-4062	477	1	georgian	georgian	NOUN
gs-4062	477	2	scientists/	scientists/	NUM
gs-4062	477	3	.	.	PUNCT
gs-4062	478	1	7	7	NUM
gs-4062	478	2	n	n	PRON
gs-4062	478	3	3	3	NUM
gs-4062	478	4	,	,	PUNCT
gs-4062	478	5	2025	2025	NUM
gs-4062	478	6	543	543	NUM
gs-4062	478	7	impact	impact	NOUN
gs-4062	478	8	:	:	PUNCT
gs-4062	478	9	this	this	DET
gs-4062	478	10	regimen	regimen	NOUN
gs-4062	478	11	eliminates	eliminate	VERB
gs-4062	478	12	the	the	DET
gs-4062	478	13	need	need	NOUN
gs-4062	478	14	for	for	ADP
gs-4062	478	15	daily	daily	ADJ
gs-4062	478	16	oral	oral	ADJ
gs-4062	478	17	pills	pill	NOUN
gs-4062	478	18	,	,	PUNCT
gs-4062	478	19	addressing	address	VERB
gs-4062	478	20	pill	pill	NOUN
gs-4062	478	21	fatigue	fatigue	NOUN
gs-4062	478	22	,	,	PUNCT
gs-4062	478	23	stigma	stigma	NOUN
gs-4062	478	24	,	,	PUNCT
gs-4062	478	25	and	and	CCONJ
gs-4062	478	26	adherence	adherence	NOUN
gs-4062	478	27	challenges	challenge	NOUN
gs-4062	478	28	.	.	PUNCT
gs-4062	479	1	it	it	PRON
gs-4062	479	2	represents	represent	VERB
gs-4062	479	3	a	a	DET
gs-4062	479	4	move	move	NOUN
gs-4062	479	5	towards	towards	ADP
gs-4062	479	6	"	"	PUNCT
gs-4062	479	7	destination	destination	NOUN
gs-4062	479	8	regimens	regimen	NOUN
gs-4062	479	9	"	"	PUNCT
gs-4062	479	10	that	that	PRON
gs-4062	479	11	prioritize	prioritize	VERB
gs-4062	479	12	patient	patient	ADJ
gs-4062	479	13	preference	preference	NOUN
gs-4062	479	14	and	and	CCONJ
gs-4062	479	15	quality	quality	NOUN
gs-4062	479	16	of	of	ADP
gs-4062	479	17	life	life	NOUN
gs-4062	479	18	.	.	PUNCT
gs-4062	480	1	pre	pre	ADJ
gs-4062	480	2	-	-	ADJ
gs-4062	480	3	exposure	exposure	ADJ
gs-4062	480	4	prophylaxis	prophylaxis	NOUN
gs-4062	480	5	(	(	PUNCT
gs-4062	480	6	prep	prep	NOUN
gs-4062	480	7	):	):	PUNCT
gs-4062	480	8	art	art	NOUN
gs-4062	480	9	is	be	AUX
gs-4062	480	10	also	also	ADV
gs-4062	480	11	used	use	VERB
gs-4062	480	12	to	to	PART
gs-4062	480	13	prevent	prevent	VERB
gs-4062	480	14	hiv	hiv	PROPN
gs-4062	480	15	acquisition	acquisition	NOUN
gs-4062	480	16	in	in	ADP
gs-4062	480	17	high	high	ADJ
gs-4062	480	18	-	-	PUNCT
gs-4062	480	19	risk	risk	NOUN
gs-4062	480	20	hivnegative	hivnegative	ADJ
gs-4062	480	21	individuals	individual	NOUN
gs-4062	480	22	.	.	PUNCT
gs-4062	481	1	the	the	DET
gs-4062	481	2	discussion	discussion	NOUN
gs-4062	481	3	has	have	AUX
gs-4062	481	4	evolved	evolve	VERB
gs-4062	481	5	from	from	ADP
gs-4062	481	6	tdf	tdf	PROPN
gs-4062	481	7	/	/	SYM
gs-4062	481	8	ftc	ftc	PROPN
gs-4062	481	9	to	to	PART
gs-4062	481	10	:	:	PUNCT
gs-4062	481	11	taf	taf	PROPN
gs-4062	481	12	/	/	SYM
gs-4062	481	13	ftc	ftc	PROPN
gs-4062	481	14	(	(	PUNCT
gs-4062	481	15	descovy	descovy	PROPN
gs-4062	481	16	®	®	PROPN
gs-4062	481	17	):	):	PUNCT
gs-4062	481	18	approved	approve	VERB
gs-4062	481	19	for	for	ADP
gs-4062	481	20	prep	prep	NOUN
gs-4062	481	21	in	in	ADP
gs-4062	481	22	men	man	NOUN
gs-4062	481	23	and	and	CCONJ
gs-4062	481	24	transgender	transgender	NOUN
gs-4062	481	25	women	woman	NOUN
gs-4062	481	26	,	,	PUNCT
gs-4062	481	27	with	with	ADP
gs-4062	481	28	potentially	potentially	ADV
gs-4062	481	29	improved	improve	VERB
gs-4062	481	30	renal	renal	ADJ
gs-4062	481	31	and	and	CCONJ
gs-4062	481	32	bone	bone	NOUN
gs-4062	481	33	safety	safety	NOUN
gs-4062	481	34	metrics	metric	NOUN
gs-4062	481	35	compared	compare	VERB
gs-4062	481	36	to	to	ADP
gs-4062	481	37	tdf	tdf	PROPN
gs-4062	481	38	/	/	SYM
gs-4062	481	39	ftc	ftc	PROPN
gs-4062	481	40	,	,	PUNCT
gs-4062	481	41	though	though	SCONJ
gs-4062	481	42	its	its	PRON
gs-4062	481	43	efficacy	efficacy	NOUN
gs-4062	481	44	in	in	ADP
gs-4062	481	45	cisgender	cisgender	PROPN
gs-4062	481	46	women	woman	NOUN
gs-4062	481	47	is	be	AUX
gs-4062	481	48	not	not	PART
gs-4062	481	49	yet	yet	ADV
gs-4062	481	50	established	establish	VERB
gs-4062	481	51	via	via	ADP
gs-4062	481	52	trials	trial	NOUN
gs-4062	481	53	.	.	PUNCT
gs-4062	482	1	long	long	ADV
gs-4062	482	2	-	-	PUNCT
gs-4062	482	3	acting	act	VERB
gs-4062	482	4	cabotegravir	cabotegravir	NOUN
gs-4062	482	5	(	(	PUNCT
gs-4062	482	6	cab	cab	NOUN
gs-4062	482	7	-	-	PUNCT
gs-4062	482	8	la	la	NOUN
gs-4062	482	9	):	):	PUNCT
gs-4062	482	10	an	an	DET
gs-4062	482	11	injectable	injectable	ADJ
gs-4062	482	12	prep	prep	NOUN
gs-4062	482	13	option	option	NOUN
gs-4062	482	14	administered	administer	VERB
gs-4062	482	15	every	every	DET
gs-4062	482	16	two	two	NUM
gs-4062	482	17	months	month	NOUN
gs-4062	482	18	,	,	PUNCT
gs-4062	482	19	which	which	PRON
gs-4062	482	20	has	have	AUX
gs-4062	482	21	shown	show	VERB
gs-4062	482	22	superior	superior	ADJ
gs-4062	482	23	efficacy	efficacy	NOUN
gs-4062	482	24	to	to	ADP
gs-4062	482	25	daily	daily	ADV
gs-4062	482	26	oral	oral	ADJ
gs-4062	482	27	tdf	tdf	PROPN
gs-4062	482	28	/	/	SYM
gs-4062	482	29	ftc	ftc	PROPN
gs-4062	482	30	in	in	ADP
gs-4062	482	31	clinical	clinical	ADJ
gs-4062	482	32	trials	trial	NOUN
gs-4062	482	33	,	,	PUNCT
gs-4062	482	34	offering	offer	VERB
gs-4062	482	35	a	a	DET
gs-4062	482	36	discrete	discrete	ADJ
gs-4062	482	37	and	and	CCONJ
gs-4062	482	38	adherence	adherence	NOUN
gs-4062	482	39	-	-	PUNCT
gs-4062	482	40	independent	independent	ADJ
gs-4062	482	41	prevention	prevention	NOUN
gs-4062	482	42	tool	tool	NOUN
gs-4062	482	43	.	.	PUNCT
gs-4062	483	1	pharmacological	pharmacological	ADJ
gs-4062	483	2	properties	property	NOUN
gs-4062	483	3	:	:	PUNCT
gs-4062	483	4	absorption	absorption	NOUN
gs-4062	483	5	,	,	PUNCT
gs-4062	483	6	distribution	distribution	NOUN
gs-4062	483	7	,	,	PUNCT
gs-4062	483	8	metabolism	metabolism	NOUN
gs-4062	483	9	,	,	PUNCT
gs-4062	483	10	and	and	CCONJ
gs-4062	483	11	excretion	excretion	NOUN
gs-4062	483	12	(	(	PUNCT
gs-4062	483	13	adme	adme	NOUN
gs-4062	483	14	)	)	PUNCT
gs-4062	483	15	the	the	DET
gs-4062	483	16	pharmacological	pharmacological	ADJ
gs-4062	483	17	profile	profile	NOUN
gs-4062	483	18	of	of	ADP
gs-4062	483	19	a	a	DET
gs-4062	483	20	drug	drug	NOUN
gs-4062	483	21	dictates	dictate	VERB
gs-4062	483	22	it	it	PRON
gs-4062	483	23	’s	’	VERB
gs-4062	483	24	dosing	dose	VERB
gs-4062	483	25	,	,	PUNCT
gs-4062	483	26	potential	potential	NOUN
gs-4062	483	27	for	for	ADP
gs-4062	483	28	interactions	interaction	NOUN
gs-4062	483	29	,	,	PUNCT
gs-4062	483	30	and	and	CCONJ
gs-4062	483	31	safety	safety	NOUN
gs-4062	483	32	.	.	PUNCT
gs-4062	484	1	pharmacokinetics	pharmacokinetic	NOUN
gs-4062	484	2	of	of	ADP
gs-4062	484	3	key	key	ADJ
gs-4062	484	4	newer	new	ADJ
gs-4062	484	5	agents	agent	NOUN
gs-4062	484	6	dolutegravir	dolutegravir	PROPN
gs-4062	484	7	(	(	PUNCT
gs-4062	484	8	dtg	dtg	PROPN
gs-4062	484	9	):	):	PUNCT
gs-4062	484	10	well	well	ADV
gs-4062	484	11	-	-	PUNCT
gs-4062	484	12	absorbed	absorb	VERB
gs-4062	484	13	orally	orally	ADV
gs-4062	484	14	.	.	PUNCT
gs-4062	485	1	it	it	PRON
gs-4062	485	2	is	be	AUX
gs-4062	485	3	a	a	DET
gs-4062	485	4	substrate	substrate	NOUN
gs-4062	485	5	of	of	ADP
gs-4062	485	6	ugt1a1	ugt1a1	NOUN
gs-4062	485	7	and	and	CCONJ
gs-4062	485	8	cyp3a4	cyp3a4	NOUN
gs-4062	485	9	and	and	CCONJ
gs-4062	485	10	is	be	AUX
gs-4062	485	11	a	a	DET
gs-4062	485	12	moderate	moderate	ADJ
gs-4062	485	13	inducer	inducer	NOUN
gs-4062	485	14	of	of	ADP
gs-4062	485	15	cyp3a4	cyp3a4	PROPN
gs-4062	485	16	.	.	PUNCT
gs-4062	486	1	it	it	PRON
gs-4062	486	2	chelates	chelate	VERB
gs-4062	486	3	polyvalent	polyvalent	NOUN
gs-4062	486	4	cations	cation	NOUN
gs-4062	486	5	(	(	PUNCT
gs-4062	486	6	e.g.	e.g.	ADV
gs-4062	486	7	,	,	PUNCT
gs-4062	486	8	ca²	ca²	NOUN
gs-4062	486	9	,	,	PUNCT
gs-4062	486	10	fe²	fe²	NOUN
gs-4062	486	11	,	,	PUNCT
gs-4062	486	12	mg²	mg²	INTJ
gs-4062	486	13	,	,	PUNCT
gs-4062	486	14	al³	al³	NOUN
gs-4062	486	15	)	)	PUNCT
gs-4062	486	16	;	;	PUNCT
gs-4062	486	17	thus	thus	ADV
gs-4062	486	18	,	,	PUNCT
gs-4062	486	19	it	it	PRON
gs-4062	486	20	must	must	AUX
gs-4062	486	21	be	be	AUX
gs-4062	486	22	taken	take	VERB
gs-4062	486	23	2	2	NUM
gs-4062	486	24	hours	hour	NOUN
gs-4062	486	25	before	before	ADP
gs-4062	486	26	or	or	CCONJ
gs-4062	486	27	6	6	NUM
gs-4062	486	28	hours	hour	NOUN
gs-4062	486	29	after	after	ADP
gs-4062	486	30	antacids	antacid	NOUN
gs-4062	486	31	or	or	CCONJ
gs-4062	486	32	supplements	supplement	NOUN
gs-4062	486	33	containing	contain	VERB
gs-4062	486	34	these	these	DET
gs-4062	486	35	cations	cation	NOUN
gs-4062	486	36	.	.	PUNCT
gs-4062	487	1	its	its	PRON
gs-4062	487	2	half	half	ADJ
gs-4062	487	3	-	-	PUNCT
gs-4062	487	4	life	life	NOUN
gs-4062	487	5	is	be	AUX
gs-4062	487	6	~14	~14	DET
gs-4062	487	7	hours	hour	NOUN
gs-4062	487	8	,	,	PUNCT
gs-4062	487	9	supporting	support	VERB
gs-4062	487	10	once	once	ADV
gs-4062	487	11	-	-	PUNCT
gs-4062	487	12	daily	daily	ADJ
gs-4062	487	13	dosing	dosing	NOUN
gs-4062	487	14	.	.	PUNCT
gs-4062	488	1	bictegravir	bictegravir	PROPN
gs-4062	488	2	(	(	PUNCT
gs-4062	488	3	bic	bic	PROPN
gs-4062	488	4	):	):	PUNCT
gs-4062	488	5	similar	similar	ADJ
gs-4062	488	6	to	to	ADP
gs-4062	488	7	dtg	dtg	PROPN
gs-4062	488	8	,	,	PUNCT
gs-4062	488	9	it	it	PRON
gs-4062	488	10	has	have	VERB
gs-4062	488	11	a	a	DET
gs-4062	488	12	long	long	ADJ
gs-4062	488	13	half	half	ADJ
gs-4062	488	14	-	-	PUNCT
gs-4062	488	15	life	life	NOUN
gs-4062	488	16	and	and	CCONJ
gs-4062	488	17	is	be	AUX
gs-4062	488	18	also	also	ADV
gs-4062	488	19	affected	affect	VERB
gs-4062	488	20	by	by	ADP
gs-4062	488	21	polyvalent	polyvalent	NOUN
gs-4062	488	22	cations	cation	NOUN
gs-4062	488	23	.	.	PUNCT
gs-4062	489	1	it	it	PRON
gs-4062	489	2	is	be	AUX
gs-4062	489	3	primarily	primarily	ADV
gs-4062	489	4	metabolized	metabolize	VERB
gs-4062	489	5	by	by	ADP
gs-4062	489	6	cyp3a	cyp3a	NOUN
gs-4062	489	7	and	and	CCONJ
gs-4062	489	8	ugt1a1	ugt1a1	NOUN
gs-4062	489	9	.	.	PUNCT
gs-4062	490	1	it	it	PRON
gs-4062	490	2	is	be	AUX
gs-4062	490	3	co	co	VERB
gs-4062	490	4	-	-	VERB
gs-4062	490	5	formulated	formulate	VERB
gs-4062	490	6	with	with	ADP
gs-4062	490	7	taf	taf	PROPN
gs-4062	490	8	/	/	SYM
gs-4062	490	9	ftc	ftc	PROPN
gs-4062	490	10	without	without	ADP
gs-4062	490	11	a	a	DET
gs-4062	490	12	booster	booster	NOUN
gs-4062	490	13	.	.	PUNCT
gs-4062	491	1	tenofovir	tenofovir	PROPN
gs-4062	491	2	alafenamide	alafenamide	PROPN
gs-4062	491	3	(	(	PUNCT
gs-4062	491	4	taf	taf	X
gs-4062	491	5	):	):	PUNCT
gs-4062	491	6	a	a	DET
gs-4062	491	7	prodrug	prodrug	NOUN
gs-4062	491	8	of	of	ADP
gs-4062	491	9	tenofovir	tenofovir	NOUN
gs-4062	491	10	(	(	PUNCT
gs-4062	491	11	tfv	tfv	PROPN
gs-4062	491	12	)	)	PUNCT
gs-4062	491	13	.	.	PUNCT
gs-4062	492	1	compared	compare	VERB
gs-4062	492	2	to	to	ADP
gs-4062	492	3	tdf	tdf	PROPN
gs-4062	492	4	,	,	PUNCT
gs-4062	492	5	taf	taf	X
gs-4062	492	6	is	be	AUX
gs-4062	492	7	more	more	ADV
gs-4062	492	8	stable	stable	ADJ
gs-4062	492	9	in	in	ADP
gs-4062	492	10	plasma	plasma	NOUN
gs-4062	492	11	,	,	PUNCT
gs-4062	492	12	leading	lead	VERB
gs-4062	492	13	to	to	ADP
gs-4062	492	14	more	more	ADV
gs-4062	492	15	efficient	efficient	ADJ
gs-4062	492	16	uptake	uptake	NOUN
gs-4062	492	17	into	into	ADP
gs-4062	492	18	lymphocytes	lymphocyte	NOUN
gs-4062	492	19	and	and	CCONJ
gs-4062	492	20	target	target	NOUN
gs-4062	492	21	cells	cell	NOUN
gs-4062	492	22	(	(	PUNCT
gs-4062	492	23	e.g.	e.g.	ADV
gs-4062	492	24	,	,	PUNCT
gs-4062	492	25	cd4	cd4	PROPN
gs-4062	492	26	cells	cell	NOUN
gs-4062	492	27	)	)	PUNCT
gs-4062	492	28	.	.	PUNCT
gs-4062	493	1	it	it	PRON
gs-4062	493	2	is	be	AUX
gs-4062	493	3	metabolized	metabolize	VERB
gs-4062	493	4	intracellularly	intracellularly	ADV
gs-4062	493	5	to	to	PART
gs-4062	493	6	tfv	tfv	VERB
gs-4062	493	7	,	,	PUNCT
gs-4062	493	8	resulting	result	VERB
gs-4062	493	9	in	in	ADP
gs-4062	493	10	>	>	NUM
gs-4062	493	11	90	90	NUM
gs-4062	493	12	%	%	NOUN
gs-4062	493	13	lower	low	ADJ
gs-4062	493	14	systemic	systemic	ADJ
gs-4062	493	15	levels	level	NOUN
gs-4062	493	16	of	of	ADP
gs-4062	493	17	tfv	tfv	PROPN
gs-4062	493	18	.	.	PUNCT
gs-4062	494	1	this	this	PRON
gs-4062	494	2	translates	translate	VERB
gs-4062	494	3	to	to	ADP
gs-4062	494	4	significantly	significantly	ADV
gs-4062	494	5	reduced	reduce	VERB
gs-4062	494	6	risk	risk	NOUN
gs-4062	494	7	of	of	ADP
gs-4062	494	8	renal	renal	ADJ
gs-4062	494	9	and	and	CCONJ
gs-4062	494	10	bone	bone	NOUN
gs-4062	494	11	toxicity	toxicity	NOUN
gs-4062	494	12	while	while	SCONJ
gs-4062	494	13	maintaining	maintain	VERB
gs-4062	494	14	high	high	ADJ
gs-4062	494	15	intracellular	intracellular	ADJ
gs-4062	494	16	efficacy	efficacy	NOUN
gs-4062	494	17	.	.	PUNCT
gs-4062	495	1	doravirine	doravirine	ADJ
gs-4062	495	2	(	(	PUNCT
gs-4062	495	3	dor	dor	NOUN
gs-4062	495	4	):	):	PUNCT
gs-4062	495	5	has	have	VERB
gs-4062	495	6	a	a	DET
gs-4062	495	7	unique	unique	ADJ
gs-4062	495	8	resistance	resistance	NOUN
gs-4062	495	9	profile	profile	NOUN
gs-4062	495	10	among	among	ADP
gs-4062	495	11	nnrtis	nnrtis	NOUN
gs-4062	495	12	.	.	PUNCT
gs-4062	496	1	it	it	PRON
gs-4062	496	2	is	be	AUX
gs-4062	496	3	primarily	primarily	ADV
gs-4062	496	4	metabolized	metabolize	VERB
gs-4062	496	5	by	by	ADP
gs-4062	496	6	cyp3a4	cyp3a4	NOUN
gs-4062	496	7	,	,	PUNCT
gs-4062	496	8	so	so	ADV
gs-4062	496	9	coadministration	coadministration	NOUN
gs-4062	496	10	with	with	ADP
gs-4062	496	11	strong	strong	ADJ
gs-4062	496	12	cyp3a	cyp3a	NOUN
gs-4062	496	13	inducers	inducer	NOUN
gs-4062	496	14	(	(	PUNCT
gs-4062	496	15	e.g.	e.g.	ADV
gs-4062	496	16	,	,	PUNCT
gs-4062	496	17	rifampin	rifampin	PROPN
gs-4062	496	18	,	,	PUNCT
gs-4062	496	19	st	st	PROPN
gs-4062	496	20	.	.	PROPN
gs-4062	496	21	john	john	PROPN
gs-4062	496	22	's	's	PART
gs-4062	496	23	wort	wort	NOUN
gs-4062	496	24	)	)	PUNCT
gs-4062	496	25	is	be	AUX
gs-4062	496	26	contraindicated	contraindicate	VERB
gs-4062	496	27	as	as	SCONJ
gs-4062	496	28	it	it	PRON
gs-4062	496	29	will	will	AUX
gs-4062	496	30	drastically	drastically	ADV
gs-4062	496	31	reduce	reduce	VERB
gs-4062	496	32	dor	dor	PROPN
gs-4062	496	33	exposure	exposure	NOUN
gs-4062	496	34	.	.	PUNCT
gs-4062	497	1	it	it	PRON
gs-4062	497	2	has	have	VERB
gs-4062	497	3	minimal	minimal	ADJ
gs-4062	497	4	neuropsychiatric	neuropsychiatric	ADJ
gs-4062	497	5	effects	effect	NOUN
gs-4062	497	6	,	,	PUNCT
gs-4062	497	7	a	a	DET
gs-4062	497	8	key	key	ADJ
gs-4062	497	9	advantage	advantage	NOUN
gs-4062	497	10	over	over	ADP
gs-4062	497	11	efavirenz	efavirenz	NOUN
gs-4062	497	12	.	.	PUNCT
gs-4062	498	1	long	long	ADV
gs-4062	498	2	-	-	PUNCT
gs-4062	498	3	acting	act	VERB
gs-4062	498	4	cabotegravir	cabotegravir	NOUN
gs-4062	498	5	and	and	CCONJ
gs-4062	498	6	rilpivirine	rilpivirine	VERB
gs-4062	498	7	:	:	PUNCT
gs-4062	498	8	their	their	PRON
gs-4062	498	9	pharmacokinetics	pharmacokinetic	NOUN
gs-4062	498	10	are	be	AUX
gs-4062	498	11	defined	define	VERB
gs-4062	498	12	by	by	ADP
gs-4062	498	13	the	the	DET
gs-4062	498	14	slow	slow	ADJ
gs-4062	498	15	dissolution	dissolution	NOUN
gs-4062	498	16	of	of	ADP
gs-4062	498	17	the	the	DET
gs-4062	498	18	drug	drug	NOUN
gs-4062	498	19	nanocrystals	nanocrystal	NOUN
gs-4062	498	20	from	from	ADP
gs-4062	498	21	the	the	DET
gs-4062	498	22	intramuscular	intramuscular	ADJ
gs-4062	498	23	depot	depot	NOUN
gs-4062	498	24	,	,	PUNCT
gs-4062	498	25	providing	provide	VERB
gs-4062	498	26	sustained	sustained	ADJ
gs-4062	498	27	release	release	NOUN
gs-4062	498	28	over	over	ADP
gs-4062	498	29	weeks	week	NOUN
gs-4062	498	30	to	to	ADP
gs-4062	498	31	months	month	NOUN
gs-4062	498	32	.	.	PUNCT
gs-4062	499	1	trough	trough	NOUN
gs-4062	499	2	concentrations	concentration	NOUN
gs-4062	499	3	must	must	AUX
gs-4062	499	4	be	be	AUX
gs-4062	499	5	maintained	maintain	VERB
gs-4062	499	6	above	above	ADP
gs-4062	499	7	a	a	DET
gs-4062	499	8	target	target	NOUN
gs-4062	499	9	threshold	threshold	NOUN
gs-4062	499	10	to	to	PART
gs-4062	499	11	ensure	ensure	VERB
gs-4062	499	12	virologic	virologic	ADJ
gs-4062	499	13	suppression	suppression	NOUN
gs-4062	499	14	and	and	CCONJ
gs-4062	499	15	prevent	prevent	VERB
gs-4062	499	16	resistance	resistance	NOUN
gs-4062	499	17	.	.	PUNCT
gs-4062	500	1	the	the	DET
gs-4062	500	2	role	role	NOUN
gs-4062	500	3	of	of	ADP
gs-4062	500	4	pharmacokinetic	pharmacokinetic	ADJ
gs-4062	500	5	enhancers	enhancer	NOUN
gs-4062	500	6	ritonavir	ritonavir	PROPN
gs-4062	500	7	(	(	PUNCT
gs-4062	500	8	rtv	rtv	PROPN
gs-4062	500	9	)	)	PUNCT
gs-4062	500	10	and	and	CCONJ
gs-4062	500	11	cobicistat	cobicistat	NOUN
gs-4062	500	12	(	(	PUNCT
gs-4062	500	13	cobi	cobi	PROPN
gs-4062	500	14	):	):	PUNCT
gs-4062	500	15	both	both	PRON
gs-4062	500	16	are	be	AUX
gs-4062	500	17	potent	potent	ADJ
gs-4062	500	18	mechanism	mechanism	NOUN
gs-4062	500	19	-	-	PUNCT
gs-4062	500	20	based	base	VERB
gs-4062	500	21	inhibitors	inhibitor	NOUN
gs-4062	500	22	of	of	ADP
gs-4062	500	23	cyp3a4	cyp3a4	NOUN
gs-4062	500	24	.	.	PUNCT
gs-4062	501	1	they	they	PRON
gs-4062	501	2	irreversibly	irreversibly	ADV
gs-4062	501	3	inhibit	inhibit	VERB
gs-4062	501	4	the	the	DET
gs-4062	501	5	enzyme	enzyme	NOUN
gs-4062	501	6	,	,	PUNCT
gs-4062	501	7	slowing	slow	VERB
gs-4062	501	8	the	the	DET
gs-4062	501	9	metabolism	metabolism	NOUN
gs-4062	501	10	of	of	ADP
gs-4062	501	11	co	co	ADJ
gs-4062	501	12	-	-	ADJ
gs-4062	501	13	administered	administered	ADJ
gs-4062	501	14	drugs	drug	NOUN
gs-4062	501	15	that	that	PRON
gs-4062	501	16	are	be	AUX
gs-4062	501	17	cyp3a4	cyp3a4	NOUN
gs-4062	501	18	substrates	substrate	NOUN
gs-4062	501	19	(	(	PUNCT
gs-4062	501	20	e.g.	e.g.	ADV
gs-4062	501	21	,	,	PUNCT
gs-4062	501	22	all	all	PRON
gs-4062	501	23	pis	pis	NOUN
gs-4062	501	24	,	,	PUNCT
gs-4062	501	25	elvitegravir	elvitegravir	PROPN
gs-4062	501	26	)	)	PUNCT
gs-4062	501	27	.	.	PUNCT
gs-4062	502	1	this	this	PRON
gs-4062	502	2	increases	increase	VERB
gs-4062	502	3	their	their	PRON
gs-4062	502	4	auc	auc	NOUN
gs-4062	502	5	and	and	CCONJ
gs-4062	502	6	halflife	halflife	NOUN
gs-4062	502	7	,	,	PUNCT
gs-4062	502	8	allowing	allow	VERB
gs-4062	502	9	for	for	ADP
gs-4062	502	10	once	once	ADV
gs-4062	502	11	or	or	CCONJ
gs-4062	502	12	twice	twice	ADV
gs-4062	502	13	-	-	PUNCT
gs-4062	502	14	daily	daily	ADJ
gs-4062	502	15	dosing	dosing	NOUN
gs-4062	502	16	.	.	PUNCT
gs-4062	503	1	cobi	cobi	PROPN
gs-4062	503	2	has	have	VERB
gs-4062	503	3	no	no	DET
gs-4062	503	4	antiviral	antiviral	ADJ
gs-4062	503	5	activity	activity	NOUN
gs-4062	503	6	and	and	CCONJ
gs-4062	503	7	is	be	AUX
gs-4062	503	8	more	more	ADJ
gs-4062	503	9	georgian	georgian	NOUN
gs-4062	503	10	scientists/	scientists/	NUM
gs-4062	503	11	.	.	PUNCT
gs-4062	504	1	7	7	NUM
gs-4062	504	2	n	n	PRON
gs-4062	504	3	3	3	NUM
gs-4062	504	4	,	,	PUNCT
gs-4062	504	5	2025	2025	NUM
gs-4062	504	6	544	544	NUM
gs-4062	504	7	selective	selective	ADJ
gs-4062	504	8	than	than	ADP
gs-4062	504	9	ritonavir	ritonavir	PROPN
gs-4062	504	10	,	,	PUNCT
gs-4062	504	11	leading	lead	VERB
gs-4062	504	12	to	to	ADP
gs-4062	504	13	a	a	DET
gs-4062	504	14	potentially	potentially	ADV
gs-4062	504	15	cleaner	clean	ADJ
gs-4062	504	16	drug	drug	NOUN
gs-4062	504	17	interaction	interaction	NOUN
gs-4062	504	18	profile	profile	NOUN
gs-4062	504	19	,	,	PUNCT
gs-4062	504	20	though	though	SCONJ
gs-4062	504	21	both	both	PRON
gs-4062	504	22	have	have	VERB
gs-4062	504	23	similar	similar	ADJ
gs-4062	504	24	effects	effect	NOUN
gs-4062	504	25	on	on	ADP
gs-4062	504	26	serum	serum	NOUN
gs-4062	504	27	creatinine	creatinine	NOUN
gs-4062	504	28	(	(	PUNCT
gs-4062	504	29	inhibiting	inhibit	VERB
gs-4062	504	30	tubular	tubular	ADJ
gs-4062	504	31	secretion	secretion	NOUN
gs-4062	504	32	)	)	PUNCT
gs-4062	504	33	.	.	PUNCT
gs-4062	505	1	toxicities	toxicity	NOUN
gs-4062	505	2	and	and	CCONJ
gs-4062	505	3	adverse	adverse	ADJ
gs-4062	505	4	event	event	NOUN
gs-4062	505	5	management	management	NOUN
gs-4062	505	6	:	:	PUNCT
gs-4062	505	7	a	a	DET
gs-4062	505	8	safety	safety	NOUN
gs-4062	505	9	-	-	PUNCT
gs-4062	505	10	first	first	ADJ
gs-4062	505	11	approach	approach	NOUN
gs-4062	505	12	while	while	SCONJ
gs-4062	505	13	newer	new	ADJ
gs-4062	505	14	arvs	arvs	NOUN
gs-4062	505	15	are	be	AUX
gs-4062	505	16	significantly	significantly	ADV
gs-4062	505	17	safer	safe	ADJ
gs-4062	505	18	than	than	ADP
gs-4062	505	19	their	their	PRON
gs-4062	505	20	predecessors	predecessor	NOUN
gs-4062	505	21	,	,	PUNCT
gs-4062	505	22	they	they	PRON
gs-4062	505	23	are	be	AUX
gs-4062	505	24	not	not	PART
gs-4062	505	25	without	without	ADP
gs-4062	505	26	toxicities	toxicity	NOUN
gs-4062	505	27	.	.	PUNCT
gs-4062	506	1	the	the	DET
gs-4062	506	2	scientific	scientific	ADJ
gs-4062	506	3	discussion	discussion	NOUN
gs-4062	506	4	heavily	heavily	ADV
gs-4062	506	5	focuses	focus	VERB
gs-4062	506	6	on	on	ADP
gs-4062	506	7	characterizing	characterizing	NOUN
gs-4062	506	8	,	,	PUNCT
gs-4062	506	9	monitoring	monitoring	NOUN
gs-4062	506	10	,	,	PUNCT
gs-4062	506	11	and	and	CCONJ
gs-4062	506	12	managing	manage	VERB
gs-4062	506	13	these	these	DET
gs-4062	506	14	adverse	adverse	ADJ
gs-4062	506	15	events	event	NOUN
gs-4062	506	16	.	.	PUNCT
gs-4062	507	1	insti	insti	NOUN
gs-4062	507	2	-	-	PUNCT
gs-4062	507	3	related	relate	VERB
gs-4062	507	4	toxicities	toxicity	NOUN
gs-4062	507	5	weight	weight	NOUN
gs-4062	507	6	gain	gain	NOUN
gs-4062	507	7	:	:	PUNCT
gs-4062	507	8	a	a	DET
gs-4062	507	9	major	major	ADJ
gs-4062	507	10	focus	focus	NOUN
gs-4062	507	11	of	of	ADP
gs-4062	507	12	recent	recent	ADJ
gs-4062	507	13	discourse	discourse	NOUN
gs-4062	507	14	.	.	PUNCT
gs-4062	508	1	instis	instis	NOUN
gs-4062	508	2	(	(	PUNCT
gs-4062	508	3	particularly	particularly	ADV
gs-4062	508	4	dtg	dtg	PROPN
gs-4062	508	5	and	and	CCONJ
gs-4062	508	6	bic	bic	PROPN
gs-4062	508	7	)	)	PUNCT
gs-4062	508	8	,	,	PUNCT
gs-4062	508	9	especially	especially	ADV
gs-4062	508	10	when	when	SCONJ
gs-4062	508	11	combined	combine	VERB
gs-4062	508	12	with	with	ADP
gs-4062	508	13	taf	taf	PROPN
gs-4062	508	14	,	,	PUNCT
gs-4062	508	15	have	have	AUX
gs-4062	508	16	been	be	AUX
gs-4062	508	17	associated	associate	VERB
gs-4062	508	18	with	with	ADP
gs-4062	508	19	more	more	ADJ
gs-4062	508	20	weight	weight	NOUN
gs-4062	508	21	gain	gain	NOUN
gs-4062	508	22	than	than	ADP
gs-4062	508	23	older	old	ADJ
gs-4062	508	24	regimens	regimen	NOUN
gs-4062	508	25	.	.	PUNCT
gs-4062	509	1	the	the	DET
gs-4062	509	2	mechanism	mechanism	NOUN
gs-4062	509	3	is	be	AUX
gs-4062	509	4	incompletely	incompletely	ADV
gs-4062	509	5	understood	understand	VERB
gs-4062	509	6	but	but	CCONJ
gs-4062	509	7	may	may	AUX
gs-4062	509	8	involve	involve	VERB
gs-4062	509	9	effects	effect	NOUN
gs-4062	509	10	on	on	ADP
gs-4062	509	11	melanocortin-4	melanocortin-4	NUM
gs-4062	509	12	receptors	receptor	NOUN
gs-4062	509	13	or	or	CCONJ
gs-4062	509	14	mitochondrial	mitochondrial	ADJ
gs-4062	509	15	function	function	NOUN
gs-4062	509	16	.	.	PUNCT
gs-4062	510	1	the	the	DET
gs-4062	510	2	clinical	clinical	ADJ
gs-4062	510	3	significance	significance	NOUN
gs-4062	510	4	of	of	ADP
gs-4062	510	5	this	this	DET
gs-4062	510	6	weight	weight	NOUN
gs-4062	510	7	gain	gain	NOUN
gs-4062	510	8	and	and	CCONJ
gs-4062	510	9	its	its	PRON
gs-4062	510	10	potential	potential	ADJ
gs-4062	510	11	link	link	NOUN
gs-4062	510	12	to	to	ADP
gs-4062	510	13	metabolic	metabolic	NOUN
gs-4062	510	14	syndrome	syndrome	NOUN
gs-4062	510	15	is	be	AUX
gs-4062	510	16	under	under	ADP
gs-4062	510	17	active	active	ADJ
gs-4062	510	18	investigation	investigation	NOUN
gs-4062	510	19	.	.	PUNCT
gs-4062	511	1	neuropsychiatric	neuropsychiatric	ADJ
gs-4062	511	2	effects	effect	NOUN
gs-4062	511	3	:	:	PUNCT
gs-4062	511	4	dolutegravir	dolutegravir	PROPN
gs-4062	511	5	has	have	AUX
gs-4062	511	6	been	be	AUX
gs-4062	511	7	associated	associate	VERB
gs-4062	511	8	with	with	ADP
gs-4062	511	9	insomnia	insomnia	NOUN
gs-4062	511	10	,	,	PUNCT
gs-4062	511	11	dizziness	dizziness	NOUN
gs-4062	511	12	,	,	PUNCT
gs-4062	511	13	headache	headache	NOUN
gs-4062	511	14	,	,	PUNCT
gs-4062	511	15	and	and	CCONJ
gs-4062	511	16	,	,	PUNCT
gs-4062	511	17	less	less	ADV
gs-4062	511	18	commonly	commonly	ADV
gs-4062	511	19	,	,	PUNCT
gs-4062	511	20	depression	depression	NOUN
gs-4062	511	21	and	and	CCONJ
gs-4062	511	22	suicidal	suicidal	ADJ
gs-4062	511	23	ideation	ideation	NOUN
gs-4062	511	24	.	.	PUNCT
gs-4062	512	1	these	these	DET
gs-4062	512	2	effects	effect	NOUN
gs-4062	512	3	are	be	AUX
gs-4062	512	4	often	often	ADV
gs-4062	512	5	transient	transient	ADJ
gs-4062	512	6	and	and	CCONJ
gs-4062	512	7	occur	occur	VERB
gs-4062	512	8	during	during	ADP
gs-4062	512	9	the	the	DET
gs-4062	512	10	first	first	ADJ
gs-4062	512	11	few	few	ADJ
gs-4062	512	12	weeks	week	NOUN
gs-4062	512	13	of	of	ADP
gs-4062	512	14	therapy	therapy	NOUN
gs-4062	512	15	.	.	PUNCT
gs-4062	513	1	for	for	ADP
gs-4062	513	2	most	most	ADJ
gs-4062	513	3	,	,	PUNCT
gs-4062	513	4	they	they	PRON
gs-4062	513	5	resolve	resolve	VERB
gs-4062	513	6	,	,	PUNCT
gs-4062	513	7	but	but	CCONJ
gs-4062	513	8	a	a	DET
gs-4062	513	9	small	small	ADJ
gs-4062	513	10	percentage	percentage	NOUN
gs-4062	513	11	of	of	ADP
gs-4062	513	12	patients	patient	NOUN
gs-4062	513	13	may	may	AUX
gs-4062	513	14	need	need	VERB
gs-4062	513	15	to	to	PART
gs-4062	513	16	switch	switch	VERB
gs-4062	513	17	to	to	ADP
gs-4062	513	18	an	an	DET
gs-4062	513	19	alternative	alternative	ADJ
gs-4062	513	20	insti	insti	NOUN
gs-4062	513	21	like	like	ADP
gs-4062	513	22	bic	bic	PROPN
gs-4062	513	23	,	,	PUNCT
gs-4062	513	24	which	which	PRON
gs-4062	513	25	appears	appear	VERB
gs-4062	513	26	to	to	PART
gs-4062	513	27	have	have	VERB
gs-4062	513	28	a	a	DET
gs-4062	513	29	lower	low	ADJ
gs-4062	513	30	incidence	incidence	NOUN
gs-4062	513	31	of	of	ADP
gs-4062	513	32	these	these	DET
gs-4062	513	33	effects	effect	NOUN
gs-4062	513	34	.	.	PUNCT
gs-4062	514	1	hypersensitivity	hypersensitivity	NOUN
gs-4062	514	2	reactions	reaction	NOUN
gs-4062	514	3	:	:	PUNCT
gs-4062	514	4	rare	rare	ADJ
gs-4062	514	5	but	but	CCONJ
gs-4062	514	6	reported	report	VERB
gs-4062	514	7	.	.	PUNCT
gs-4062	515	1	nnrti	nnrti	NOUN
gs-4062	515	2	-	-	PUNCT
gs-4062	515	3	related	relate	VERB
gs-4062	515	4	toxicities	toxicity	NOUN
gs-4062	515	5	cns	cns	NOUN
gs-4062	515	6	effects	effect	NOUN
gs-4062	515	7	:	:	PUNCT
gs-4062	515	8	efavirenz	efavirenz	NOUN
gs-4062	515	9	is	be	AUX
gs-4062	515	10	notorious	notorious	ADJ
gs-4062	515	11	for	for	ADP
gs-4062	515	12	neuropsychiatric	neuropsychiatric	ADJ
gs-4062	515	13	effects	effect	NOUN
gs-4062	515	14	(	(	PUNCT
gs-4062	515	15	dizziness	dizziness	NOUN
gs-4062	515	16	,	,	PUNCT
gs-4062	515	17	abnormal	abnormal	ADJ
gs-4062	515	18	dreams	dream	NOUN
gs-4062	515	19	,	,	PUNCT
gs-4062	515	20	insomnia	insomnia	NOUN
gs-4062	515	21	,	,	PUNCT
gs-4062	515	22	and	and	CCONJ
gs-4062	515	23	depression	depression	NOUN
gs-4062	515	24	)	)	PUNCT
gs-4062	515	25	.	.	PUNCT
gs-4062	516	1	doravirine	doravirine	PROPN
gs-4062	516	2	was	be	AUX
gs-4062	516	3	specifically	specifically	ADV
gs-4062	516	4	designed	design	VERB
gs-4062	516	5	to	to	PART
gs-4062	516	6	avoid	avoid	VERB
gs-4062	516	7	these	these	PRON
gs-4062	516	8	and	and	CCONJ
gs-4062	516	9	has	have	VERB
gs-4062	516	10	a	a	DET
gs-4062	516	11	cns	cns	NOUN
gs-4062	516	12	profile	profile	NOUN
gs-4062	516	13	similar	similar	ADJ
gs-4062	516	14	to	to	ADP
gs-4062	516	15	placebo	placebo	NOUN
gs-4062	516	16	.	.	PUNCT
gs-4062	517	1	rash	rash	ADJ
gs-4062	517	2	:	:	PUNCT
gs-4062	517	3	common	common	ADJ
gs-4062	517	4	with	with	ADP
gs-4062	517	5	all	all	DET
gs-4062	517	6	nnrtis	nnrtis	ADJ
gs-4062	517	7	,	,	PUNCT
gs-4062	517	8	usually	usually	ADV
gs-4062	517	9	mild	mild	ADJ
gs-4062	517	10	and	and	CCONJ
gs-4062	517	11	self	self	NOUN
gs-4062	517	12	-	-	PUNCT
gs-4062	517	13	limiting	limit	VERB
gs-4062	517	14	.	.	PUNCT
gs-4062	518	1	severe	severe	ADJ
gs-4062	518	2	rash	rash	NOUN
gs-4062	518	3	,	,	PUNCT
gs-4062	518	4	including	include	VERB
gs-4062	518	5	stevensjohnson	stevensjohnson	NOUN
gs-4062	518	6	syndrome	syndrome	NOUN
gs-4062	518	7	,	,	PUNCT
gs-4062	518	8	is	be	AUX
gs-4062	518	9	rare	rare	ADJ
gs-4062	518	10	.	.	PUNCT
gs-4062	519	1	nrti	nrti	NOUN
gs-4062	519	2	-	-	PUNCT
gs-4062	519	3	related	relate	VERB
gs-4062	519	4	toxicities	toxicity	NOUN
gs-4062	519	5	taf	taf	X
gs-4062	519	6	vs.	vs.	ADP
gs-4062	519	7	tdf	tdf	PROPN
gs-4062	519	8	:	:	PUNCT
gs-4062	519	9	this	this	PRON
gs-4062	519	10	is	be	AUX
gs-4062	519	11	a	a	DET
gs-4062	519	12	critical	critical	ADJ
gs-4062	519	13	discussion	discussion	NOUN
gs-4062	519	14	.	.	PUNCT
gs-4062	520	1	tdf	tdf	NOUN
gs-4062	520	2	:	:	PUNCT
gs-4062	520	3	associated	associate	VERB
gs-4062	520	4	with	with	ADP
gs-4062	520	5	proximal	proximal	ADJ
gs-4062	520	6	renal	renal	ADJ
gs-4062	520	7	tubulopathy	tubulopathy	NOUN
gs-4062	520	8	,	,	PUNCT
gs-4062	520	9	leading	lead	VERB
gs-4062	520	10	to	to	ADP
gs-4062	520	11	declines	decline	NOUN
gs-4062	520	12	in	in	ADP
gs-4062	520	13	glomerular	glomerular	ADJ
gs-4062	520	14	filtration	filtration	NOUN
gs-4062	520	15	rate	rate	NOUN
gs-4062	520	16	(	(	PUNCT
gs-4062	520	17	egfr	egfr	NOUN
gs-4062	520	18	)	)	PUNCT
gs-4062	520	19	,	,	PUNCT
gs-4062	520	20	fanconi	fanconi	NOUN
gs-4062	520	21	syndrome	syndrome	PROPN
gs-4062	520	22	,	,	PUNCT
gs-4062	520	23	and	and	CCONJ
gs-4062	520	24	increased	increase	VERB
gs-4062	520	25	risk	risk	NOUN
gs-4062	520	26	of	of	ADP
gs-4062	520	27	chronic	chronic	ADJ
gs-4062	520	28	kidney	kidney	NOUN
gs-4062	520	29	disease	disease	NOUN
gs-4062	520	30	.	.	PUNCT
gs-4062	521	1	it	it	PRON
gs-4062	521	2	also	also	ADV
gs-4062	521	3	causes	cause	VERB
gs-4062	521	4	reduced	reduced	ADJ
gs-4062	521	5	bone	bone	NOUN
gs-4062	521	6	mineral	mineral	NOUN
gs-4062	521	7	density	density	NOUN
gs-4062	521	8	(	(	PUNCT
gs-4062	521	9	bmd	bmd	PROPN
gs-4062	521	10	)	)	PUNCT
gs-4062	521	11	and	and	CCONJ
gs-4062	521	12	increased	increase	VERB
gs-4062	521	13	fracture	fracture	NOUN
gs-4062	521	14	risk	risk	NOUN
gs-4062	521	15	due	due	ADP
gs-4062	521	16	to	to	PART
gs-4062	521	17	phosphate	phosphate	VERB
gs-4062	521	18	wasting	wasting	NOUN
gs-4062	521	19	and	and	CCONJ
gs-4062	521	20	altered	alter	VERB
gs-4062	521	21	vitamin	vitamin	NOUN
gs-4062	521	22	d	d	NOUN
gs-4062	521	23	metabolism	metabolism	NOUN
gs-4062	521	24	.	.	PUNCT
gs-4062	522	1	taf	taf	X
gs-4062	522	2	:	:	PUNCT
gs-4062	522	3	dramatically	dramatically	ADV
gs-4062	522	4	reduces	reduce	VERB
gs-4062	522	5	these	these	DET
gs-4062	522	6	risks	risk	NOUN
gs-4062	522	7	due	due	ADP
gs-4062	522	8	to	to	ADP
gs-4062	522	9	its	its	PRON
gs-4062	522	10	targeted	target	VERB
gs-4062	522	11	delivery	delivery	NOUN
gs-4062	522	12	and	and	CCONJ
gs-4062	522	13	lower	low	ADJ
gs-4062	522	14	systemic	systemic	ADJ
gs-4062	522	15	tfv	tfv	NOUN
gs-4062	522	16	exposure	exposure	NOUN
gs-4062	522	17	.	.	PUNCT
gs-4062	523	1	studies	study	NOUN
gs-4062	523	2	show	show	VERB
gs-4062	523	3	minimal	minimal	ADJ
gs-4062	523	4	impact	impact	NOUN
gs-4062	523	5	on	on	ADP
gs-4062	523	6	renal	renal	ADJ
gs-4062	523	7	markers	marker	NOUN
gs-4062	523	8	and	and	CCONJ
gs-4062	523	9	bmd	bmd	PROPN
gs-4062	523	10	.	.	PUNCT
gs-4062	524	1	taf	taf	PROPN
gs-4062	524	2	is	be	AUX
gs-4062	524	3	associated	associate	VERB
gs-4062	524	4	with	with	ADP
gs-4062	524	5	greater	great	ADJ
gs-4062	524	6	increases	increase	NOUN
gs-4062	524	7	in	in	ADP
gs-4062	524	8	lipid	lipid	ADJ
gs-4062	524	9	parameters	parameter	NOUN
gs-4062	524	10	(	(	PUNCT
gs-4062	524	11	cholesterol	cholesterol	NOUN
gs-4062	524	12	,	,	PUNCT
gs-4062	524	13	triglycerides	triglyceride	NOUN
gs-4062	524	14	)	)	PUNCT
gs-4062	524	15	than	than	ADP
gs-4062	524	16	tdf	tdf	PROPN
gs-4062	524	17	,	,	PUNCT
gs-4062	524	18	though	though	SCONJ
gs-4062	524	19	the	the	DET
gs-4062	524	20	clinical	clinical	ADJ
gs-4062	524	21	impact	impact	NOUN
gs-4062	524	22	of	of	ADP
gs-4062	524	23	this	this	PRON
gs-4062	524	24	is	be	AUX
gs-4062	524	25	unclear	unclear	ADJ
gs-4062	524	26	.	.	PUNCT
gs-4062	525	1	unique	unique	ADJ
gs-4062	525	2	and	and	CCONJ
gs-4062	525	3	class	class	NOUN
gs-4062	525	4	-	-	PUNCT
gs-4062	525	5	specific	specific	ADJ
gs-4062	525	6	toxicities	toxicity	NOUN
gs-4062	525	7	abacavir	abacavir	VERB
gs-4062	525	8	hypersensitivity	hypersensitivity	VERB
gs-4062	525	9	:	:	PUNCT
gs-4062	525	10	a	a	DET
gs-4062	525	11	potentially	potentially	ADV
gs-4062	525	12	fatal	fatal	ADJ
gs-4062	525	13	hypersensitivity	hypersensitivity	NOUN
gs-4062	525	14	reaction	reaction	NOUN
gs-4062	525	15	strongly	strongly	ADV
gs-4062	525	16	associated	associate	VERB
gs-4062	525	17	with	with	ADP
gs-4062	525	18	the	the	DET
gs-4062	525	19	hla	hla	NOUN
gs-4062	525	20	-	-	PUNCT
gs-4062	525	21	b*5701	b*5701	NOUN
gs-4062	525	22	allele	allele	NOUN
gs-4062	525	23	.	.	PUNCT
gs-4062	526	1	*	*	PUNCT
gs-4062	526	2	*	*	PUNCT
gs-4062	526	3	screening	screen	VERB
gs-4062	526	4	for	for	ADP
gs-4062	526	5	hla	hla	NOUN
gs-4062	526	6	-	-	PUNCT
gs-4062	526	7	b*5701	b*5701	NOUN
gs-4062	526	8	is	be	AUX
gs-4062	526	9	mandatory	mandatory	ADJ
gs-4062	526	10	before	before	ADP
gs-4062	526	11	initiation	initiation	NOUN
gs-4062	526	12	;	;	PUNCT
gs-4062	526	13	*	*	PUNCT
gs-4062	526	14	*	*	PUNCT
gs-4062	526	15	the	the	DET
gs-4062	526	16	drug	drug	NOUN
gs-4062	526	17	is	be	AUX
gs-4062	526	18	contraindicated	contraindicate	VERB
gs-4062	526	19	in	in	ADP
gs-4062	526	20	positive	positive	ADJ
gs-4062	526	21	individuals	individual	NOUN
gs-4062	526	22	.	.	PUNCT
gs-4062	527	1	ibalizumab	ibalizumab	PROPN
gs-4062	527	2	:	:	PUNCT
gs-4062	527	3	adverse	adverse	ADJ
gs-4062	527	4	events	event	NOUN
gs-4062	527	5	include	include	VERB
gs-4062	527	6	diarrhea	diarrhea	NOUN
gs-4062	527	7	,	,	PUNCT
gs-4062	527	8	dizziness	dizziness	NOUN
gs-4062	527	9	,	,	PUNCT
gs-4062	527	10	nausea	nausea	NOUN
gs-4062	527	11	,	,	PUNCT
gs-4062	527	12	and	and	CCONJ
gs-4062	527	13	rash	rash	ADJ
gs-4062	527	14	.	.	PUNCT
gs-4062	528	1	as	as	ADP
gs-4062	528	2	a	a	DET
gs-4062	528	3	monoclonal	monoclonal	NOUN
gs-4062	528	4	antibody	antibody	NOUN
gs-4062	528	5	,	,	PUNCT
gs-4062	528	6	there	there	PRON
gs-4062	528	7	is	be	VERB
gs-4062	528	8	a	a	DET
gs-4062	528	9	potential	potential	NOUN
gs-4062	528	10	for	for	ADP
gs-4062	528	11	immunogenicity	immunogenicity	NOUN
gs-4062	528	12	.	.	PUNCT
gs-4062	529	1	fostemsavir	fostemsavir	PROPN
gs-4062	529	2	:	:	PUNCT
gs-4062	529	3	can	can	AUX
gs-4062	529	4	cause	cause	VERB
gs-4062	529	5	immune	immune	ADJ
gs-4062	529	6	reconstitution	reconstitution	NOUN
gs-4062	529	7	syndrome	syndrome	NOUN
gs-4062	529	8	and	and	CCONJ
gs-4062	529	9	increases	increase	NOUN
gs-4062	529	10	in	in	ADP
gs-4062	529	11	liver	liver	NOUN
gs-4062	529	12	enzymes	enzyme	NOUN
gs-4062	529	13	.	.	PUNCT
gs-4062	530	1	it	it	PRON
gs-4062	530	2	has	have	VERB
gs-4062	530	3	a	a	DET
gs-4062	530	4	qt	qt	NOUN
gs-4062	530	5	prolongation	prolongation	NOUN
gs-4062	530	6	warning	warn	VERB
gs-4062	530	7	at	at	ADP
gs-4062	530	8	doses	dose	NOUN
gs-4062	530	9	higher	high	ADJ
gs-4062	530	10	than	than	ADP
gs-4062	530	11	those	those	PRON
gs-4062	530	12	approved	approve	VERB
gs-4062	530	13	.	.	PUNCT
gs-4062	531	1	georgian	georgian	NOUN
gs-4062	531	2	scientists/	scientists/	NUM
gs-4062	531	3	.	.	PUNCT
gs-4062	532	1	7	7	NUM
gs-4062	532	2	n	n	PRON
gs-4062	532	3	3	3	NUM
gs-4062	532	4	,	,	PUNCT
gs-4062	532	5	2025	2025	NUM
gs-4062	532	6	545	545	NUM
gs-4062	533	1	the	the	DET
gs-4062	533	2	dolutegravir	dolutegravir	NOUN
gs-4062	533	3	and	and	CCONJ
gs-4062	533	4	neural	neural	ADJ
gs-4062	533	5	tube	tube	NOUN
gs-4062	533	6	defect	defect	NOUN
gs-4062	533	7	(	(	PUNCT
gs-4062	533	8	ntd	ntd	NOUN
gs-4062	533	9	)	)	PUNCT
gs-4062	533	10	scare	scare	NOUN
gs-4062	533	11	:	:	PUNCT
gs-4062	533	12	a	a	DET
gs-4062	533	13	significant	significant	ADJ
gs-4062	533	14	safety	safety	NOUN
gs-4062	533	15	signal	signal	NOUN
gs-4062	533	16	emerged	emerge	VERB
gs-4062	533	17	from	from	ADP
gs-4062	533	18	a	a	DET
gs-4062	533	19	preliminary	preliminary	ADJ
gs-4062	533	20	study	study	NOUN
gs-4062	533	21	in	in	ADP
gs-4062	533	22	botswana	botswana	PROPN
gs-4062	533	23	in	in	ADP
gs-4062	533	24	2018	2018	NUM
gs-4062	533	25	that	that	PRON
gs-4062	533	26	suggested	suggest	VERB
gs-4062	533	27	a	a	DET
gs-4062	533	28	potential	potential	ADJ
gs-4062	533	29	link	link	NOUN
gs-4062	533	30	between	between	ADP
gs-4062	533	31	periconceptional	periconceptional	ADJ
gs-4062	533	32	dtg	dtg	PROPN
gs-4062	533	33	exposure	exposure	NOUN
gs-4062	533	34	and	and	CCONJ
gs-4062	533	35	an	an	DET
gs-4062	533	36	increased	increase	VERB
gs-4062	533	37	risk	risk	NOUN
gs-4062	533	38	of	of	ADP
gs-4062	533	39	neural	neural	ADJ
gs-4062	533	40	tube	tube	NOUN
gs-4062	533	41	defects	defect	NOUN
gs-4062	533	42	.	.	PUNCT
gs-4062	534	1	this	this	DET
gs-4062	534	2	led	lead	VERB
gs-4062	534	3	guidelines	guideline	NOUN
gs-4062	534	4	to	to	PART
gs-4062	534	5	initially	initially	ADV
gs-4062	534	6	recommend	recommend	VERB
gs-4062	534	7	against	against	ADP
gs-4062	534	8	its	its	PRON
gs-4062	534	9	use	use	NOUN
gs-4062	534	10	in	in	ADP
gs-4062	534	11	women	woman	NOUN
gs-4062	534	12	of	of	ADP
gs-4062	534	13	childbearing	childbearing	NOUN
gs-4062	534	14	potential	potential	NOUN
gs-4062	534	15	.	.	PUNCT
gs-4062	535	1	subsequent	subsequent	ADJ
gs-4062	535	2	data	datum	NOUN
gs-4062	535	3	from	from	ADP
gs-4062	535	4	larger	large	ADJ
gs-4062	535	5	,	,	PUNCT
gs-4062	535	6	expanded	expand	VERB
gs-4062	535	7	observational	observational	ADJ
gs-4062	535	8	studies	study	NOUN
gs-4062	535	9	have	have	AUX
gs-4062	535	10	been	be	AUX
gs-4062	535	11	reassuring	reassure	VERB
gs-4062	535	12	,	,	PUNCT
gs-4062	535	13	showing	show	VERB
gs-4062	535	14	the	the	DET
gs-4062	535	15	risk	risk	NOUN
gs-4062	535	16	to	to	PART
gs-4062	535	17	be	be	AUX
gs-4062	535	18	much	much	ADV
gs-4062	535	19	lower	low	ADJ
gs-4062	535	20	than	than	SCONJ
gs-4062	535	21	initially	initially	ADV
gs-4062	535	22	feared	fear	VERB
gs-4062	535	23	(	(	PUNCT
gs-4062	535	24	~0.3	~0.3	NUM
gs-4062	535	25	%	%	NOUN
gs-4062	535	26	vs.	vs.	ADP
gs-4062	535	27	the	the	DET
gs-4062	535	28	background	background	NOUN
gs-4062	535	29	rate	rate	NOUN
gs-4062	535	30	of	of	ADP
gs-4062	535	31	~0.1	~0.1	NOUN
gs-4062	535	32	%	%	NOUN
gs-4062	535	33	)	)	PUNCT
gs-4062	535	34	.	.	PUNCT
gs-4062	536	1	guidelines	guideline	NOUN
gs-4062	536	2	now	now	ADV
gs-4062	536	3	position	position	VERB
gs-4062	536	4	dtg	dtg	PROPN
gs-4062	536	5	as	as	ADP
gs-4062	536	6	a	a	DET
gs-4062	536	7	preferred	preferred	ADJ
gs-4062	536	8	option	option	NOUN
gs-4062	536	9	for	for	ADP
gs-4062	536	10	all	all	DET
gs-4062	536	11	populations	population	NOUN
gs-4062	536	12	,	,	PUNCT
gs-4062	536	13	including	include	VERB
gs-4062	536	14	women	woman	NOUN
gs-4062	536	15	trying	try	VERB
gs-4062	536	16	to	to	PART
gs-4062	536	17	conceive	conceive	VERB
gs-4062	536	18	and	and	CCONJ
gs-4062	536	19	pregnant	pregnant	ADJ
gs-4062	536	20	women	woman	NOUN
gs-4062	536	21	,	,	PUNCT
gs-4062	536	22	due	due	ADP
gs-4062	536	23	to	to	ADP
gs-4062	536	24	its	its	PRON
gs-4062	536	25	high	high	ADJ
gs-4062	536	26	efficacy	efficacy	NOUN
gs-4062	536	27	and	and	CCONJ
gs-4062	536	28	high	high	ADJ
gs-4062	536	29	barrier	barrier	NOUN
gs-4062	536	30	to	to	ADP
gs-4062	536	31	resistance	resistance	NOUN
gs-4062	536	32	,	,	PUNCT
gs-4062	536	33	with	with	ADP
gs-4062	536	34	the	the	DET
gs-4062	536	35	recommendation	recommendation	NOUN
gs-4062	536	36	for	for	ADP
gs-4062	536	37	consistent	consistent	ADJ
gs-4062	536	38	folate	folate	NOUN
gs-4062	536	39	supplementation	supplementation	NOUN
gs-4062	536	40	.	.	PUNCT
gs-4062	537	1	this	this	DET
gs-4062	537	2	episode	episode	NOUN
gs-4062	537	3	highlights	highlight	VERB
gs-4062	537	4	the	the	DET
gs-4062	537	5	dynamic	dynamic	ADJ
gs-4062	537	6	nature	nature	NOUN
gs-4062	537	7	of	of	ADP
gs-4062	537	8	pharmacovigilance	pharmacovigilance	NOUN
gs-4062	537	9	and	and	CCONJ
gs-4062	537	10	how	how	SCONJ
gs-4062	537	11	scientific	scientific	ADJ
gs-4062	537	12	discussion	discussion	NOUN
gs-4062	537	13	continuously	continuously	ADV
gs-4062	537	14	refines	refine	VERB
gs-4062	537	15	our	our	PRON
gs-4062	537	16	understanding	understanding	NOUN
gs-4062	537	17	of	of	ADP
gs-4062	537	18	drug	drug	NOUN
gs-4062	537	19	safety	safety	NOUN
gs-4062	537	20	.	.	PUNCT
gs-4062	538	1	the	the	DET
gs-4062	538	2	scientific	scientific	ADJ
gs-4062	538	3	discussion	discussion	NOUN
gs-4062	538	4	surrounding	surround	VERB
gs-4062	538	5	new	new	ADJ
gs-4062	538	6	antiretroviral	antiretroviral	ADJ
gs-4062	538	7	medicines	medicine	NOUN
gs-4062	538	8	is	be	AUX
gs-4062	538	9	a	a	DET
gs-4062	538	10	testament	testament	NOUN
gs-4062	538	11	to	to	ADP
gs-4062	538	12	the	the	DET
gs-4062	538	13	incredible	incredible	ADJ
gs-4062	538	14	progress	progress	NOUN
gs-4062	538	15	in	in	ADP
gs-4062	538	16	the	the	DET
gs-4062	538	17	fight	fight	NOUN
gs-4062	538	18	against	against	ADP
gs-4062	538	19	hiv	hiv	PROPN
gs-4062	538	20	/	/	SYM
gs-4062	538	21	aids	aids	PROPN
gs-4062	538	22	.	.	PUNCT
gs-4062	539	1	the	the	DET
gs-4062	539	2	evolution	evolution	NOUN
gs-4062	539	3	from	from	ADP
gs-4062	539	4	toxic	toxic	ADJ
gs-4062	539	5	,	,	PUNCT
gs-4062	539	6	cumbersome	cumbersome	ADJ
gs-4062	539	7	regimens	regimen	NOUN
gs-4062	539	8	to	to	ADP
gs-4062	539	9	highly	highly	ADV
gs-4062	539	10	potent	potent	ADJ
gs-4062	539	11	,	,	PUNCT
gs-4062	539	12	well	well	ADV
gs-4062	539	13	-	-	PUNCT
gs-4062	539	14	tolerated	tolerate	VERB
gs-4062	539	15	,	,	PUNCT
gs-4062	539	16	single	single	ADJ
gs-4062	539	17	-	-	PUNCT
gs-4062	539	18	tablet	tablet	NOUN
gs-4062	539	19	and	and	CCONJ
gs-4062	539	20	even	even	ADV
gs-4062	539	21	long	long	ADV
gs-4062	539	22	-	-	PUNCT
gs-4062	539	23	acting	act	VERB
gs-4062	539	24	injectable	injectable	ADJ
gs-4062	539	25	formulations	formulation	NOUN
gs-4062	539	26	has	have	AUX
gs-4062	539	27	transformed	transform	VERB
gs-4062	539	28	patient	patient	ADJ
gs-4062	539	29	outcomes	outcome	NOUN
gs-4062	539	30	and	and	CCONJ
gs-4062	539	31	quality	quality	NOUN
gs-4062	539	32	of	of	ADP
gs-4062	539	33	life	life	NOUN
gs-4062	539	34	.	.	PUNCT
gs-4062	540	1	the	the	DET
gs-4062	540	2	current	current	ADJ
gs-4062	540	3	arsenal	arsenal	NOUN
gs-4062	540	4	,	,	PUNCT
gs-4062	540	5	led	lead	VERB
gs-4062	540	6	by	by	ADP
gs-4062	540	7	instis	insti	NOUN
gs-4062	540	8	like	like	ADP
gs-4062	540	9	bic	bic	PROPN
gs-4062	540	10	and	and	CCONJ
gs-4062	540	11	dtg	dtg	PROPN
gs-4062	540	12	,	,	PUNCT
gs-4062	540	13	and	and	CCONJ
gs-4062	540	14	supported	support	VERB
gs-4062	540	15	by	by	ADP
gs-4062	540	16	safer	safe	ADJ
gs-4062	540	17	nrti	nrti	NOUN
gs-4062	540	18	backbones	backbone	NOUN
gs-4062	540	19	like	like	ADP
gs-4062	540	20	taf	taf	PROPN
gs-4062	540	21	/	/	SYM
gs-4062	540	22	ftc	ftc	PROPN
gs-4062	540	23	,	,	PUNCT
gs-4062	540	24	allows	allow	VERB
gs-4062	540	25	for	for	ADP
gs-4062	540	26	the	the	DET
gs-4062	540	27	effective	effective	ADJ
gs-4062	540	28	and	and	CCONJ
gs-4062	540	29	durable	durable	ADJ
gs-4062	540	30	suppression	suppression	NOUN
gs-4062	540	31	of	of	ADP
gs-4062	540	32	hiv	hiv	PROPN
gs-4062	540	33	with	with	ADP
gs-4062	540	34	minimal	minimal	ADJ
gs-4062	540	35	side	side	NOUN
gs-4062	540	36	effects	effect	NOUN
gs-4062	540	37	for	for	ADP
gs-4062	540	38	the	the	DET
gs-4062	540	39	vast	vast	ADJ
gs-4062	540	40	majority	majority	NOUN
gs-4062	540	41	of	of	ADP
gs-4062	540	42	patients	patient	NOUN
gs-4062	540	43	.	.	PUNCT
gs-4062	541	1	for	for	ADP
gs-4062	541	2	those	those	PRON
gs-4062	541	3	with	with	ADP
gs-4062	541	4	multidrug	multidrug	NOUN
gs-4062	541	5	resistance	resistance	NOUN
gs-4062	541	6	,	,	PUNCT
gs-4062	541	7	novel	novel	ADJ
gs-4062	541	8	agents	agent	NOUN
gs-4062	541	9	like	like	ADP
gs-4062	541	10	ibalizumab	ibalizumab	NOUN
gs-4062	541	11	and	and	CCONJ
gs-4062	541	12	fostemsavir	fostemsavir	NOUN
gs-4062	541	13	provide	provide	VERB
gs-4062	541	14	crucial	crucial	ADJ
gs-4062	541	15	lifelines	lifeline	NOUN
gs-4062	541	16	.	.	PUNCT
gs-4062	542	1	the	the	DET
gs-4062	542	2	discourse	discourse	NOUN
gs-4062	542	3	now	now	ADV
gs-4062	542	4	extends	extend	VERB
gs-4062	542	5	beyond	beyond	ADP
gs-4062	542	6	mere	mere	ADJ
gs-4062	542	7	viral	viral	ADJ
gs-4062	542	8	suppression	suppression	NOUN
gs-4062	542	9	to	to	ADP
gs-4062	542	10	optimizing	optimize	VERB
gs-4062	542	11	long	long	ADJ
gs-4062	542	12	-	-	PUNCT
gs-4062	542	13	term	term	NOUN
gs-4062	542	14	health	health	NOUN
gs-4062	542	15	,	,	PUNCT
gs-4062	542	16	managing	manage	VERB
gs-4062	542	17	comorbidities	comorbiditie	NOUN
gs-4062	542	18	,	,	PUNCT
gs-4062	542	19	and	and	CCONJ
gs-4062	542	20	improving	improve	VERB
gs-4062	542	21	the	the	DET
gs-4062	542	22	patient	patient	ADJ
gs-4062	542	23	experience	experience	NOUN
gs-4062	542	24	.	.	PUNCT
gs-4062	543	1	key	key	ADJ
gs-4062	543	2	topics	topic	NOUN
gs-4062	543	3	of	of	ADP
gs-4062	543	4	ongoing	ongoing	ADJ
gs-4062	543	5	research	research	NOUN
gs-4062	543	6	and	and	CCONJ
gs-4062	543	7	discussion	discussion	NOUN
gs-4062	543	8	include	include	VERB
gs-4062	543	9	:	:	PUNCT
gs-4062	543	10	understanding	understanding	NOUN
gs-4062	543	11	and	and	CCONJ
gs-4062	543	12	mitigating	mitigate	VERB
gs-4062	543	13	insti	insti	NOUN
gs-4062	543	14	-	-	PUNCT
gs-4062	543	15	associated	associate	VERB
gs-4062	543	16	weight	weight	NOUN
gs-4062	543	17	gain	gain	NOUN
gs-4062	543	18	:	:	PUNCT
gs-4062	543	19	determining	determine	VERB
gs-4062	543	20	the	the	DET
gs-4062	543	21	mechanisms	mechanism	NOUN
gs-4062	543	22	and	and	CCONJ
gs-4062	543	23	long	long	ADJ
gs-4062	543	24	-	-	PUNCT
gs-4062	543	25	term	term	NOUN
gs-4062	543	26	cardiovascular	cardiovascular	ADJ
gs-4062	543	27	and	and	CCONJ
gs-4062	543	28	metabolic	metabolic	NOUN
gs-4062	543	29	consequences	consequence	NOUN
gs-4062	543	30	.	.	PUNCT
gs-4062	544	1	expanding	expand	VERB
gs-4062	544	2	long	long	ADV
gs-4062	544	3	-	-	PUNCT
gs-4062	544	4	acting	act	VERB
gs-4062	544	5	technologies	technology	NOUN
gs-4062	544	6	:	:	PUNCT
gs-4062	544	7	developing	develop	VERB
gs-4062	544	8	implants	implant	NOUN
gs-4062	544	9	,	,	PUNCT
gs-4062	544	10	longer	long	ADV
gs-4062	544	11	-	-	PUNCT
gs-4062	544	12	acting	act	VERB
gs-4062	544	13	injectables	injectable	NOUN
gs-4062	544	14	(	(	PUNCT
gs-4062	544	15	e.g.	e.g.	ADV
gs-4062	544	16	,	,	PUNCT
gs-4062	544	17	every	every	DET
gs-4062	544	18	6	6	NUM
gs-4062	544	19	months	month	NOUN
gs-4062	544	20	)	)	PUNCT
gs-4062	544	21	,	,	PUNCT
gs-4062	544	22	and	and	CCONJ
gs-4062	544	23	combination	combination	NOUN
gs-4062	544	24	packages	package	NOUN
gs-4062	544	25	for	for	ADP
gs-4062	544	26	both	both	DET
gs-4062	544	27	treatment	treatment	NOUN
gs-4062	544	28	and	and	CCONJ
gs-4062	544	29	prevention	prevention	NOUN
gs-4062	544	30	.	.	PUNCT
gs-4062	545	1	moving	move	VERB
gs-4062	545	2	towards	towards	ADP
gs-4062	545	3	functional	functional	ADJ
gs-4062	545	4	cure	cure	NOUN
gs-4062	545	5	and	and	CCONJ
gs-4062	545	6	remission	remission	NOUN
gs-4062	545	7	:	:	PUNCT
gs-4062	545	8	investigating	investigate	VERB
gs-4062	545	9	broadly	broadly	ADV
gs-4062	545	10	neutralizing	neutralize	VERB
gs-4062	545	11	antibodies	antibody	NOUN
gs-4062	545	12	(	(	PUNCT
gs-4062	545	13	bnabs	bnab	NOUN
gs-4062	545	14	)	)	PUNCT
gs-4062	545	15	,	,	PUNCT
gs-4062	545	16	therapeutic	therapeutic	ADJ
gs-4062	545	17	vaccines	vaccine	NOUN
gs-4062	545	18	,	,	PUNCT
gs-4062	545	19	latency	latency	NOUN
gs-4062	545	20	-	-	PUNCT
gs-4062	545	21	reversing	reverse	VERB
gs-4062	545	22	agents	agent	NOUN
gs-4062	545	23	,	,	PUNCT
gs-4062	545	24	and	and	CCONJ
gs-4062	545	25	gene	gene	NOUN
gs-4062	545	26	-	-	PUNCT
gs-4062	545	27	editing	edit	VERB
gs-4062	545	28	technologies	technology	NOUN
gs-4062	545	29	(	(	PUNCT
gs-4062	545	30	e.g.	e.g.	ADV
gs-4062	545	31	,	,	PUNCT
gs-4062	545	32	crispr	crispr	NOUN
gs-4062	545	33	-	-	PUNCT
gs-4062	545	34	cas9	cas9	NOUN
gs-4062	545	35	)	)	PUNCT
gs-4062	545	36	to	to	PART
gs-4062	545	37	achieve	achieve	VERB
gs-4062	545	38	a	a	DET
gs-4062	545	39	state	state	NOUN
gs-4062	545	40	of	of	ADP
gs-4062	545	41	art	art	NOUN
gs-4062	545	42	-	-	PUNCT
gs-4062	545	43	free	free	ADJ
gs-4062	545	44	remission	remission	NOUN
gs-4062	545	45	.	.	PUNCT
gs-4062	546	1	personalized	personalized	ADJ
gs-4062	546	2	medicine	medicine	NOUN
gs-4062	546	3	:	:	PUNCT
gs-4062	546	4	using	use	VERB
gs-4062	546	5	genetic	genetic	ADJ
gs-4062	546	6	testing	testing	NOUN
gs-4062	546	7	(	(	PUNCT
gs-4062	546	8	e.g.	e.g.	ADV
gs-4062	546	9	,	,	PUNCT
gs-4062	546	10	hla	hla	NOUN
gs-4062	546	11	-	-	PUNCT
gs-4062	546	12	b*5701	b*5701	NOUN
gs-4062	546	13	,	,	PUNCT
gs-4062	546	14	pharmacogenomics	pharmacogenomic	NOUN
gs-4062	546	15	for	for	ADP
gs-4062	546	16	drug	drug	NOUN
gs-4062	546	17	metabolism	metabolism	NOUN
gs-4062	546	18	)	)	PUNCT
gs-4062	546	19	to	to	PART
gs-4062	546	20	further	far	ADV
gs-4062	546	21	tailor	tailor	NOUN
gs-4062	546	22	regimens	regimen	NOUN
gs-4062	546	23	to	to	ADP
gs-4062	546	24	individual	individual	ADJ
gs-4062	546	25	patients	patient	NOUN
gs-4062	546	26	to	to	PART
gs-4062	546	27	maximize	maximize	VERB
gs-4062	546	28	efficacy	efficacy	NOUN
gs-4062	546	29	and	and	CCONJ
gs-4062	546	30	minimize	minimize	VERB
gs-4062	546	31	toxicity	toxicity	NOUN
gs-4062	546	32	.	.	PUNCT
gs-4062	547	1	global	global	ADJ
gs-4062	547	2	access	access	NOUN
gs-4062	547	3	and	and	CCONJ
gs-4062	547	4	equity	equity	NOUN
gs-4062	547	5	:	:	PUNCT
gs-4062	547	6	ensuring	ensure	VERB
gs-4062	547	7	that	that	SCONJ
gs-4062	547	8	these	these	DET
gs-4062	547	9	scientific	scientific	ADJ
gs-4062	547	10	advancements	advancement	NOUN
gs-4062	547	11	translate	translate	VERB
gs-4062	547	12	into	into	ADP
gs-4062	547	13	accessible	accessible	ADJ
gs-4062	547	14	and	and	CCONJ
gs-4062	547	15	affordable	affordable	ADJ
gs-4062	547	16	treatments	treatment	NOUN
gs-4062	547	17	for	for	ADP
gs-4062	547	18	all	all	DET
gs-4062	547	19	populations	population	NOUN
gs-4062	547	20	worldwide	worldwide	ADV
gs-4062	547	21	,	,	PUNCT
gs-4062	547	22	closing	close	VERB
gs-4062	547	23	the	the	DET
gs-4062	547	24	gap	gap	NOUN
gs-4062	547	25	between	between	ADP
gs-4062	547	26	high	high	ADJ
gs-4062	547	27	-	-	PUNCT
gs-4062	547	28	income	income	NOUN
gs-4062	547	29	and	and	CCONJ
gs-4062	547	30	lowand	lowand	ADJ
gs-4062	547	31	middle	middle	ADJ
gs-4062	547	32	-	-	PUNCT
gs-4062	547	33	income	income	NOUN
gs-4062	547	34	countries	country	NOUN
gs-4062	547	35	.	.	PUNCT
gs-4062	548	1	the	the	DET
gs-4062	548	2	manifestation	manifestation	NOUN
gs-4062	548	3	of	of	ADP
gs-4062	548	4	scientific	scientific	ADJ
gs-4062	548	5	discussion	discussion	NOUN
gs-4062	548	6	in	in	ADP
gs-4062	548	7	this	this	DET
gs-4062	548	8	field	field	NOUN
gs-4062	548	9	is	be	AUX
gs-4062	548	10	a	a	DET
gs-4062	548	11	continuous	continuous	ADJ
gs-4062	548	12	cycle	cycle	NOUN
gs-4062	548	13	of	of	ADP
gs-4062	548	14	discovery	discovery	NOUN
gs-4062	548	15	,	,	PUNCT
gs-4062	548	16	clinical	clinical	ADJ
gs-4062	548	17	validation	validation	NOUN
gs-4062	548	18	,	,	PUNCT
gs-4062	548	19	post	post	ADJ
gs-4062	548	20	-	-	ADJ
gs-4062	548	21	marketing	marketing	ADJ
gs-4062	548	22	surveillance	surveillance	NOUN
gs-4062	548	23	,	,	PUNCT
gs-4062	548	24	and	and	CCONJ
gs-4062	548	25	guideline	guideline	NOUN
gs-4062	548	26	refinement	refinement	NOUN
gs-4062	548	27	.	.	PUNCT
gs-4062	549	1	it	it	PRON
gs-4062	549	2	is	be	AUX
gs-4062	549	3	a	a	DET
gs-4062	549	4	collaborative	collaborative	ADJ
gs-4062	549	5	effort	effort	NOUN
gs-4062	549	6	among	among	ADP
gs-4062	549	7	basic	basic	ADJ
gs-4062	549	8	scientists	scientist	NOUN
gs-4062	549	9	,	,	PUNCT
gs-4062	549	10	clinical	clinical	ADJ
gs-4062	549	11	researchers	researcher	NOUN
gs-4062	549	12	,	,	PUNCT
gs-4062	549	13	physicians	physician	NOUN
gs-4062	549	14	,	,	PUNCT
gs-4062	549	15	pharmacists	pharmacist	NOUN
gs-4062	549	16	,	,	PUNCT
gs-4062	549	17	and	and	CCONJ
gs-4062	549	18	,	,	PUNCT
gs-4062	549	19	most	most	ADV
gs-4062	549	20	importantly	importantly	ADV
gs-4062	549	21	,	,	PUNCT
gs-4062	549	22	patients	patient	NOUN
gs-4062	549	23	.	.	PUNCT
gs-4062	550	1	this	this	DET
gs-4062	550	2	dynamic	dynamic	ADJ
gs-4062	550	3	process	process	NOUN
gs-4062	550	4	ensures	ensure	VERB
gs-4062	550	5	that	that	SCONJ
gs-4062	550	6	the	the	DET
gs-4062	550	7	management	management	NOUN
gs-4062	550	8	of	of	ADP
gs-4062	550	9	hiv	hiv	PROPN
gs-4062	550	10	continues	continue	VERB
gs-4062	550	11	to	to	PART
gs-4062	550	12	evolve	evolve	VERB
gs-4062	550	13	,	,	PUNCT
gs-4062	550	14	driven	drive	VERB
gs-4062	550	15	by	by	ADP
gs-4062	550	16	the	the	DET
gs-4062	550	17	unwavering	unwavering	ADJ
gs-4062	550	18	goal	goal	NOUN
gs-4062	550	19	of	of	ADP
gs-4062	550	20	ultimately	ultimately	ADV
gs-4062	550	21	ending	end	VERB
gs-4062	550	22	the	the	DET
gs-4062	550	23	epidemic	epidemic	NOUN
gs-4062	550	24	.	.	PUNCT
gs-4062	551	1	the	the	DET
gs-4062	551	2	foundation	foundation	NOUN
gs-4062	551	3	:	:	PUNCT
gs-4062	551	4	hiv	hiv	PROPN
gs-4062	551	5	replication	replication	NOUN
gs-4062	551	6	cycle	cycle	NOUN
gs-4062	551	7	and	and	CCONJ
gs-4062	551	8	drug	drug	NOUN
gs-4062	551	9	targets	target	NOUN
gs-4062	551	10	to	to	PART
gs-4062	551	11	appreciate	appreciate	VERB
gs-4062	551	12	the	the	DET
gs-4062	551	13	scientific	scientific	ADJ
gs-4062	551	14	rationale	rationale	NOUN
gs-4062	551	15	behind	behind	ADP
gs-4062	551	16	antiretroviral	antiretroviral	ADJ
gs-4062	551	17	drug	drug	NOUN
gs-4062	551	18	development	development	NOUN
gs-4062	551	19	,	,	PUNCT
gs-4062	551	20	one	one	PRON
gs-4062	551	21	must	must	AUX
gs-4062	551	22	first	first	ADV
gs-4062	551	23	understand	understand	VERB
gs-4062	551	24	the	the	DET
gs-4062	551	25	replication	replication	NOUN
gs-4062	551	26	cycle	cycle	NOUN
gs-4062	551	27	of	of	ADP
gs-4062	551	28	hiv	hiv	PROPN
gs-4062	551	29	,	,	PUNCT
gs-4062	551	30	a	a	DET
gs-4062	551	31	retrovirus	retrovirus	NOUN
gs-4062	551	32	whose	whose	DET
gs-4062	551	33	life	life	NOUN
gs-4062	551	34	cycle	cycle	NOUN
gs-4062	551	35	is	be	AUX
gs-4062	551	36	a	a	DET
gs-4062	551	37	complex	complex	ADJ
gs-4062	551	38	sequence	sequence	NOUN
gs-4062	551	39	of	of	ADP
gs-4062	551	40	events	event	NOUN
gs-4062	551	41	,	,	PUNCT
gs-4062	551	42	each	each	PRON
gs-4062	551	43	representing	represent	VERB
gs-4062	551	44	a	a	DET
gs-4062	551	45	potential	potential	ADJ
gs-4062	551	46	target	target	NOUN
gs-4062	551	47	for	for	ADP
gs-4062	551	48	pharmacological	pharmacological	ADJ
gs-4062	551	49	intervention	intervention	NOUN
gs-4062	551	50	.	.	PUNCT
gs-4062	552	1	the	the	DET
gs-4062	552	2	cycle	cycle	NOUN
gs-4062	552	3	begins	begin	VERB
gs-4062	552	4	with	with	ADP
gs-4062	552	5	the	the	DET
gs-4062	552	6	binding	binding	NOUN
gs-4062	552	7	of	of	ADP
gs-4062	552	8	viral	viral	ADJ
gs-4062	552	9	envelope	envelope	NOUN
gs-4062	552	10	glycoproteins	glycoprotein	NOUN
gs-4062	552	11	to	to	ADP
gs-4062	552	12	specific	specific	ADJ
gs-4062	552	13	host	host	NOUN
gs-4062	552	14	cell	cell	NOUN
gs-4062	552	15	receptors	receptor	NOUN
gs-4062	552	16	,	,	PUNCT
gs-4062	552	17	primarily	primarily	ADV
gs-4062	552	18	the	the	DET
gs-4062	552	19	cd4	cd4	PROPN
gs-4062	552	20	georgian	georgian	NOUN
gs-4062	552	21	scientists/	scientists/	NUM
gs-4062	552	22	.	.	PUNCT
gs-4062	553	1	7	7	NUM
gs-4062	553	2	n	n	PRON
gs-4062	553	3	3	3	NUM
gs-4062	553	4	,	,	PUNCT
gs-4062	553	5	2025	2025	NUM
gs-4062	553	6	546	546	NUM
gs-4062	553	7	receptor	receptor	NOUN
gs-4062	553	8	,	,	PUNCT
gs-4062	553	9	followed	follow	VERB
gs-4062	553	10	by	by	ADP
gs-4062	553	11	interaction	interaction	NOUN
gs-4062	553	12	with	with	ADP
gs-4062	553	13	coreceptors	coreceptor	NOUN
gs-4062	553	14	,	,	PUNCT
gs-4062	553	15	ccr5	ccr5	NOUN
gs-4062	553	16	or	or	CCONJ
gs-4062	553	17	cxcr4	cxcr4	NOUN
gs-4062	553	18	.	.	PUNCT
gs-4062	554	1	this	this	DET
gs-4062	554	2	engagement	engagement	NOUN
gs-4062	554	3	triggers	trigger	VERB
gs-4062	554	4	fusion	fusion	NOUN
gs-4062	554	5	of	of	ADP
gs-4062	554	6	the	the	DET
gs-4062	554	7	viral	viral	ADJ
gs-4062	554	8	envelope	envelope	NOUN
gs-4062	554	9	with	with	ADP
gs-4062	554	10	the	the	DET
gs-4062	554	11	host	host	NOUN
gs-4062	554	12	cell	cell	NOUN
gs-4062	554	13	membrane	membrane	NOUN
gs-4062	554	14	,	,	PUNCT
gs-4062	554	15	allowing	allow	VERB
gs-4062	554	16	the	the	DET
gs-4062	554	17	viral	viral	ADJ
gs-4062	554	18	core	core	NOUN
gs-4062	554	19	to	to	PART
gs-4062	554	20	enter	enter	VERB
gs-4062	554	21	the	the	DET
gs-4062	554	22	cytoplasm	cytoplasm	NOUN
gs-4062	554	23	.	.	PUNCT
gs-4062	555	1	within	within	ADP
gs-4062	555	2	the	the	DET
gs-4062	555	3	core	core	NOUN
gs-4062	555	4	,	,	PUNCT
gs-4062	555	5	the	the	DET
gs-4062	555	6	viral	viral	ADJ
gs-4062	555	7	rna	rna	NOUN
gs-4062	555	8	genome	genome	NOUN
gs-4062	555	9	is	be	AUX
gs-4062	555	10	reverse	reverse	ADJ
gs-4062	555	11	transcribed	transcribe	VERB
gs-4062	555	12	into	into	ADP
gs-4062	555	13	double	double	ADV
gs-4062	555	14	-	-	PUNCT
gs-4062	555	15	stranded	strand	VERB
gs-4062	555	16	dna	dna	NOUN
gs-4062	555	17	by	by	ADP
gs-4062	555	18	the	the	DET
gs-4062	555	19	enzyme	enzyme	NOUN
gs-4062	555	20	reverse	reverse	NOUN
gs-4062	555	21	transcriptase	transcriptase	NOUN
gs-4062	555	22	,	,	PUNCT
gs-4062	555	23	a	a	DET
gs-4062	555	24	process	process	NOUN
gs-4062	555	25	notoriously	notoriously	ADV
gs-4062	555	26	error	error	NOUN
gs-4062	555	27	-	-	PUNCT
gs-4062	555	28	prone	prone	ADJ
gs-4062	555	29	and	and	CCONJ
gs-4062	555	30	responsible	responsible	ADJ
gs-4062	555	31	for	for	ADP
gs-4062	555	32	the	the	DET
gs-4062	555	33	virus	virus	NOUN
gs-4062	555	34	's	's	PART
gs-4062	555	35	high	high	ADJ
gs-4062	555	36	genetic	genetic	ADJ
gs-4062	555	37	variability	variability	NOUN
gs-4062	555	38	.	.	PUNCT
gs-4062	556	1	this	this	DET
gs-4062	556	2	newly	newly	ADV
gs-4062	556	3	formed	form	VERB
gs-4062	556	4	viral	viral	ADJ
gs-4062	556	5	dna	dna	NOUN
gs-4062	556	6	,	,	PUNCT
gs-4062	556	7	now	now	ADV
gs-4062	556	8	called	call	VERB
gs-4062	556	9	a	a	DET
gs-4062	556	10	pre	pre	ADJ
gs-4062	556	11	-	-	ADJ
gs-4062	556	12	integration	integration	NOUN
gs-4062	556	13	complex	complex	NOUN
gs-4062	556	14	,	,	PUNCT
gs-4062	556	15	is	be	AUX
gs-4062	556	16	then	then	ADV
gs-4062	556	17	transported	transport	VERB
gs-4062	556	18	into	into	ADP
gs-4062	556	19	the	the	DET
gs-4062	556	20	nucleus	nucleus	NOUN
gs-4062	556	21	where	where	SCONJ
gs-4062	556	22	it	it	PRON
gs-4062	556	23	is	be	AUX
gs-4062	556	24	integrated	integrate	VERB
gs-4062	556	25	into	into	ADP
gs-4062	556	26	the	the	DET
gs-4062	556	27	host	host	NOUN
gs-4062	556	28	chromosome	chromosome	NOUN
gs-4062	556	29	by	by	ADP
gs-4062	556	30	the	the	DET
gs-4062	556	31	viral	viral	ADJ
gs-4062	556	32	enzyme	enzyme	NOUN
gs-4062	556	33	integrase	integrase	NOUN
gs-4062	556	34	.	.	PUNCT
gs-4062	557	1	this	this	DET
gs-4062	557	2	integrated	integrate	VERB
gs-4062	557	3	provirus	provirus	NOUN
gs-4062	557	4	becomes	become	VERB
gs-4062	557	5	a	a	DET
gs-4062	557	6	permanent	permanent	ADJ
gs-4062	557	7	part	part	NOUN
gs-4062	557	8	of	of	ADP
gs-4062	557	9	the	the	DET
gs-4062	557	10	host	host	NOUN
gs-4062	557	11	cell	cell	NOUN
gs-4062	557	12	's	's	PART
gs-4062	557	13	genetic	genetic	ADJ
gs-4062	557	14	material	material	NOUN
gs-4062	557	15	,	,	PUNCT
gs-4062	557	16	enabling	enable	VERB
gs-4062	557	17	latent	latent	NOUN
gs-4062	557	18	infection	infection	NOUN
gs-4062	557	19	and	and	CCONJ
gs-4062	557	20	long	long	ADJ
gs-4062	557	21	-	-	PUNCT
gs-4062	557	22	term	term	NOUN
gs-4062	557	23	persistence	persistence	NOUN
gs-4062	557	24	.	.	PUNCT
gs-4062	558	1	upon	upon	SCONJ
gs-4062	558	2	cellular	cellular	ADJ
gs-4062	558	3	activation	activation	NOUN
gs-4062	558	4	,	,	PUNCT
gs-4062	558	5	the	the	DET
gs-4062	558	6	host	host	NOUN
gs-4062	558	7	's	's	PART
gs-4062	558	8	transcriptional	transcriptional	ADJ
gs-4062	558	9	machinery	machinery	NOUN
gs-4062	558	10	is	be	AUX
gs-4062	558	11	co	co	VERB
gs-4062	558	12	-	-	VERB
gs-4062	558	13	opted	opt	VERB
gs-4062	558	14	to	to	PART
gs-4062	558	15	transcribe	transcribe	VERB
gs-4062	558	16	the	the	DET
gs-4062	558	17	proviral	proviral	ADJ
gs-4062	558	18	dna	dna	NOUN
gs-4062	558	19	into	into	ADP
gs-4062	558	20	new	new	ADJ
gs-4062	558	21	viral	viral	ADJ
gs-4062	558	22	rna	rna	NOUN
gs-4062	558	23	strands	strand	NOUN
gs-4062	558	24	.	.	PUNCT
gs-4062	559	1	these	these	DET
gs-4062	559	2	rna	rna	NOUN
gs-4062	559	3	strands	strand	NOUN
gs-4062	559	4	serve	serve	VERB
gs-4062	559	5	both	both	PRON
gs-4062	559	6	as	as	ADP
gs-4062	559	7	genomes	genome	NOUN
gs-4062	559	8	for	for	ADP
gs-4062	559	9	new	new	ADJ
gs-4062	559	10	virions	virion	NOUN
gs-4062	559	11	and	and	CCONJ
gs-4062	559	12	as	as	ADP
gs-4062	559	13	mrna	mrna	NOUN
gs-4062	559	14	for	for	ADP
gs-4062	559	15	the	the	DET
gs-4062	559	16	translation	translation	NOUN
gs-4062	559	17	of	of	ADP
gs-4062	559	18	viral	viral	ADJ
gs-4062	559	19	polyproteins	polyprotein	NOUN
gs-4062	559	20	.	.	PUNCT
gs-4062	560	1	these	these	DET
gs-4062	560	2	large	large	ADJ
gs-4062	560	3	,	,	PUNCT
gs-4062	560	4	inactive	inactive	ADJ
gs-4062	560	5	polyproteins	polyprotein	NOUN
gs-4062	560	6	must	must	AUX
gs-4062	560	7	be	be	AUX
gs-4062	560	8	cleaved	cleave	VERB
gs-4062	560	9	by	by	ADP
gs-4062	560	10	the	the	DET
gs-4062	560	11	viral	viral	ADJ
gs-4062	560	12	protease	protease	NOUN
gs-4062	560	13	enzyme	enzyme	NOUN
gs-4062	560	14	into	into	ADP
gs-4062	560	15	individual	individual	ADJ
gs-4062	560	16	functional	functional	ADJ
gs-4062	560	17	components	component	NOUN
gs-4062	560	18	—	—	PUNCT
gs-4062	560	19	such	such	ADJ
gs-4062	560	20	as	as	ADP
gs-4062	560	21	reverse	reverse	ADJ
gs-4062	560	22	transcriptase	transcriptase	NOUN
gs-4062	560	23	,	,	PUNCT
gs-4062	560	24	integrase	integrase	NOUN
gs-4062	560	25	,	,	PUNCT
gs-4062	560	26	and	and	CCONJ
gs-4062	560	27	structural	structural	ADJ
gs-4062	560	28	proteins	protein	NOUN
gs-4062	560	29	.	.	PUNCT
gs-4062	561	1	the	the	DET
gs-4062	561	2	final	final	ADJ
gs-4062	561	3	assembly	assembly	NOUN
gs-4062	561	4	of	of	ADP
gs-4062	561	5	these	these	DET
gs-4062	561	6	components	component	NOUN
gs-4062	561	7	occurs	occur	VERB
gs-4062	561	8	at	at	ADP
gs-4062	561	9	the	the	DET
gs-4062	561	10	host	host	NOUN
gs-4062	561	11	cell	cell	NOUN
gs-4062	561	12	membrane	membrane	NOUN
gs-4062	561	13	,	,	PUNCT
gs-4062	561	14	where	where	SCONJ
gs-4062	561	15	new	new	ADJ
gs-4062	561	16	immature	immature	ADJ
gs-4062	561	17	virions	virion	NOUN
gs-4062	561	18	bud	bud	VERB
gs-4062	561	19	off	off	ADP
gs-4062	561	20	from	from	ADP
gs-4062	561	21	the	the	DET
gs-4062	561	22	cell	cell	NOUN
gs-4062	561	23	.	.	PUNCT
gs-4062	562	1	the	the	DET
gs-4062	562	2	last	last	ADJ
gs-4062	562	3	step	step	NOUN
gs-4062	562	4	is	be	AUX
gs-4062	562	5	maturation	maturation	NOUN
gs-4062	562	6	,	,	PUNCT
gs-4062	562	7	where	where	SCONJ
gs-4062	562	8	protease	protease	NOUN
gs-4062	562	9	-	-	PUNCT
gs-4062	562	10	mediated	mediate	VERB
gs-4062	562	11	cleavage	cleavage	NOUN
gs-4062	562	12	triggers	trigger	VERB
gs-4062	562	13	a	a	DET
gs-4062	562	14	structural	structural	ADJ
gs-4062	562	15	reorganization	reorganization	NOUN
gs-4062	562	16	,	,	PUNCT
gs-4062	562	17	resulting	result	VERB
gs-4062	562	18	in	in	ADP
gs-4062	562	19	a	a	DET
gs-4062	562	20	mature	mature	ADJ
gs-4062	562	21	,	,	PUNCT
gs-4062	562	22	infectious	infectious	ADJ
gs-4062	562	23	virus	virus	NOUN
gs-4062	562	24	capable	capable	ADJ
gs-4062	562	25	of	of	ADP
gs-4062	562	26	infecting	infect	VERB
gs-4062	562	27	new	new	ADJ
gs-4062	562	28	cells	cell	NOUN
gs-4062	562	29	.	.	PUNCT
gs-4062	563	1	each	each	PRON
gs-4062	563	2	of	of	ADP
gs-4062	563	3	these	these	DET
gs-4062	563	4	stages	stage	NOUN
gs-4062	563	5	—	—	PUNCT
gs-4062	563	6	entry	entry	NOUN
gs-4062	563	7	,	,	PUNCT
gs-4062	563	8	reverse	reverse	ADJ
gs-4062	563	9	transcription	transcription	NOUN
gs-4062	563	10	,	,	PUNCT
gs-4062	563	11	integration	integration	NOUN
gs-4062	563	12	,	,	PUNCT
gs-4062	563	13	and	and	CCONJ
gs-4062	563	14	maturation	maturation	NOUN
gs-4062	563	15	—	—	PUNCT
gs-4062	563	16	presents	present	VERB
gs-4062	563	17	a	a	DET
gs-4062	563	18	critical	critical	ADJ
gs-4062	563	19	vulnerability	vulnerability	NOUN
gs-4062	563	20	.	.	PUNCT
gs-4062	564	1	the	the	DET
gs-4062	564	2	scientific	scientific	ADJ
gs-4062	564	3	endeavor	endeavor	NOUN
gs-4062	564	4	in	in	ADP
gs-4062	564	5	antiretroviral	antiretroviral	ADJ
gs-4062	564	6	drug	drug	NOUN
gs-4062	564	7	discovery	discovery	NOUN
gs-4062	564	8	has	have	AUX
gs-4062	564	9	been	be	AUX
gs-4062	564	10	to	to	PART
gs-4062	564	11	design	design	VERB
gs-4062	564	12	molecules	molecule	NOUN
gs-4062	564	13	that	that	PRON
gs-4062	564	14	can	can	AUX
gs-4062	564	15	selectively	selectively	ADV
gs-4062	564	16	inhibit	inhibit	VERB
gs-4062	564	17	these	these	DET
gs-4062	564	18	viral	viral	ADJ
gs-4062	564	19	enzymes	enzyme	NOUN
gs-4062	564	20	or	or	CCONJ
gs-4062	564	21	block	block	VERB
gs-4062	564	22	these	these	DET
gs-4062	564	23	essential	essential	ADJ
gs-4062	564	24	processes	process	NOUN
gs-4062	564	25	without	without	ADP
gs-4062	564	26	causing	cause	VERB
gs-4062	564	27	undue	undue	ADJ
gs-4062	564	28	harm	harm	NOUN
gs-4062	564	29	to	to	PART
gs-4062	564	30	host	host	VERB
gs-4062	564	31	cellular	cellular	ADJ
gs-4062	564	32	functions	function	NOUN
gs-4062	564	33	.	.	PUNCT
gs-4062	565	1	the	the	DET
gs-4062	565	2	success	success	NOUN
gs-4062	565	3	of	of	ADP
gs-4062	565	4	this	this	DET
gs-4062	565	5	endeavor	endeavor	NOUN
gs-4062	565	6	is	be	AUX
gs-4062	565	7	evidenced	evidence	VERB
gs-4062	565	8	by	by	ADP
gs-4062	565	9	the	the	DET
gs-4062	565	10	existence	existence	NOUN
gs-4062	565	11	of	of	ADP
gs-4062	565	12	multiple	multiple	ADJ
gs-4062	565	13	drug	drug	NOUN
gs-4062	565	14	classes	class	NOUN
gs-4062	565	15	,	,	PUNCT
gs-4062	565	16	each	each	PRON
gs-4062	565	17	corresponding	correspond	VERB
gs-4062	565	18	to	to	ADP
gs-4062	565	19	a	a	DET
gs-4062	565	20	specific	specific	ADJ
gs-4062	565	21	stage	stage	NOUN
gs-4062	565	22	in	in	ADP
gs-4062	565	23	this	this	DET
gs-4062	565	24	life	life	NOUN
gs-4062	565	25	cycle	cycle	NOUN
gs-4062	565	26	.	.	PUNCT
gs-4062	566	1	the	the	DET
gs-4062	566	2	continuous	continuous	ADJ
gs-4062	566	3	refinement	refinement	NOUN
gs-4062	566	4	of	of	ADP
gs-4062	566	5	these	these	DET
gs-4062	566	6	agents	agent	NOUN
gs-4062	566	7	,	,	PUNCT
gs-4062	566	8	improving	improve	VERB
gs-4062	566	9	their	their	PRON
gs-4062	566	10	potency	potency	NOUN
gs-4062	566	11	,	,	PUNCT
gs-4062	566	12	safety	safety	NOUN
gs-4062	566	13	,	,	PUNCT
gs-4062	566	14	and	and	CCONJ
gs-4062	566	15	genetic	genetic	ADJ
gs-4062	566	16	barrier	barrier	NOUN
gs-4062	566	17	to	to	ADP
gs-4062	566	18	resistance	resistance	NOUN
gs-4062	566	19	,	,	PUNCT
gs-4062	566	20	constitutes	constitute	VERB
gs-4062	566	21	the	the	DET
gs-4062	566	22	core	core	NOUN
gs-4062	566	23	of	of	ADP
gs-4062	566	24	progress	progress	NOUN
gs-4062	566	25	in	in	ADP
gs-4062	566	26	hiv	hiv	PROPN
gs-4062	566	27	therapeutics	therapeutic	NOUN
gs-4062	566	28	.	.	PUNCT
gs-4062	567	1	classification	classification	NOUN
gs-4062	567	2	of	of	ADP
gs-4062	567	3	antiretroviral	antiretroviral	ADJ
gs-4062	567	4	agents	agent	NOUN
gs-4062	567	5	the	the	DET
gs-4062	567	6	classification	classification	NOUN
gs-4062	567	7	of	of	ADP
gs-4062	567	8	antiretroviral	antiretroviral	ADJ
gs-4062	567	9	drugs	drug	NOUN
gs-4062	567	10	is	be	AUX
gs-4062	567	11	a	a	DET
gs-4062	567	12	direct	direct	ADJ
gs-4062	567	13	reflection	reflection	NOUN
gs-4062	567	14	of	of	ADP
gs-4062	567	15	their	their	PRON
gs-4062	567	16	mechanism	mechanism	NOUN
gs-4062	567	17	of	of	ADP
gs-4062	567	18	action	action	NOUN
gs-4062	567	19	,	,	PUNCT
gs-4062	567	20	providing	provide	VERB
gs-4062	567	21	a	a	DET
gs-4062	567	22	logical	logical	ADJ
gs-4062	567	23	framework	framework	NOUN
gs-4062	567	24	for	for	ADP
gs-4062	567	25	understanding	understand	VERB
gs-4062	567	26	their	their	PRON
gs-4062	567	27	use	use	NOUN
gs-4062	567	28	and	and	CCONJ
gs-4062	567	29	for	for	ADP
gs-4062	567	30	constructing	construct	VERB
gs-4062	567	31	effective	effective	ADJ
gs-4062	567	32	combination	combination	NOUN
gs-4062	567	33	regimens	regimen	NOUN
gs-4062	567	34	.	.	PUNCT
gs-4062	568	1	the	the	DET
gs-4062	568	2	oldest	old	ADJ
gs-4062	568	3	class	class	NOUN
gs-4062	568	4	is	be	AUX
gs-4062	568	5	the	the	DET
gs-4062	568	6	nucleoside	nucleoside	ADV
gs-4062	568	7	reverse	reverse	ADJ
gs-4062	568	8	transcriptase	transcriptase	NOUN
gs-4062	568	9	inhibitors	inhibitor	NOUN
gs-4062	568	10	.	.	PUNCT
gs-4062	569	1	these	these	DET
gs-4062	569	2	agents	agent	NOUN
gs-4062	569	3	are	be	AUX
gs-4062	569	4	analogues	analogue	NOUN
gs-4062	569	5	of	of	ADP
gs-4062	569	6	the	the	DET
gs-4062	569	7	natural	natural	ADJ
gs-4062	569	8	nucleosides	nucleoside	NOUN
gs-4062	569	9	that	that	PRON
gs-4062	569	10	constitute	constitute	VERB
gs-4062	569	11	dna	dna	NOUN
gs-4062	569	12	.	.	PUNCT
gs-4062	570	1	they	they	PRON
gs-4062	570	2	are	be	AUX
gs-4062	570	3	phosphorylated	phosphorylate	VERB
gs-4062	570	4	within	within	ADP
gs-4062	570	5	the	the	DET
gs-4062	570	6	host	host	NOUN
gs-4062	570	7	cell	cell	NOUN
gs-4062	570	8	to	to	ADP
gs-4062	570	9	their	their	PRON
gs-4062	570	10	active	active	ADJ
gs-4062	570	11	triphosphate	triphosphate	NOUN
gs-4062	570	12	forms	form	NOUN
gs-4062	570	13	.	.	PUNCT
gs-4062	571	1	when	when	SCONJ
gs-4062	571	2	incorporated	incorporate	VERB
gs-4062	571	3	by	by	ADP
gs-4062	571	4	reverse	reverse	ADJ
gs-4062	571	5	transcriptase	transcriptase	NOUN
gs-4062	571	6	into	into	ADP
gs-4062	571	7	the	the	DET
gs-4062	571	8	growing	grow	VERB
gs-4062	571	9	viral	viral	ADJ
gs-4062	571	10	dna	dna	NOUN
gs-4062	571	11	chain	chain	NOUN
gs-4062	571	12	,	,	PUNCT
gs-4062	571	13	they	they	PRON
gs-4062	571	14	act	act	VERB
gs-4062	571	15	as	as	ADP
gs-4062	571	16	chain	chain	NOUN
gs-4062	571	17	terminators	terminator	NOUN
gs-4062	571	18	because	because	SCONJ
gs-4062	571	19	they	they	PRON
gs-4062	571	20	lack	lack	VERB
gs-4062	571	21	a	a	DET
gs-4062	571	22	3'-hydroxyl	3'-hydroxyl	PROPN
gs-4062	571	23	group	group	NOUN
gs-4062	571	24	necessary	necessary	ADJ
gs-4062	571	25	for	for	ADP
gs-4062	571	26	forming	form	VERB
gs-4062	571	27	the	the	DET
gs-4062	571	28	phosphodiester	phosphodiester	ADJ
gs-4062	571	29	bond	bond	NOUN
gs-4062	571	30	with	with	ADP
gs-4062	571	31	the	the	DET
gs-4062	571	32	next	next	ADJ
gs-4062	571	33	incoming	incoming	ADJ
gs-4062	571	34	nucleoside	nucleoside	NOUN
gs-4062	571	35	.	.	PUNCT
gs-4062	572	1	this	this	PRON
gs-4062	572	2	halts	halt	VERB
gs-4062	572	3	the	the	DET
gs-4062	572	4	dna	dna	PROPN
gs-4062	572	5	chain	chain	NOUN
gs-4062	572	6	elongation	elongation	NOUN
gs-4062	572	7	and	and	CCONJ
gs-4062	572	8	aborts	abort	VERB
gs-4062	572	9	the	the	DET
gs-4062	572	10	reverse	reverse	ADJ
gs-4062	572	11	transcription	transcription	NOUN
gs-4062	572	12	process	process	NOUN
gs-4062	572	13	.	.	PUNCT
gs-4062	573	1	examples	example	NOUN
gs-4062	573	2	include	include	VERB
gs-4062	573	3	abacavir	abacavir	NOUN
gs-4062	573	4	,	,	PUNCT
gs-4062	573	5	lamivudine	lamivudine	NOUN
gs-4062	573	6	,	,	PUNCT
gs-4062	573	7	and	and	CCONJ
gs-4062	573	8	emtricitabine	emtricitabine	NOUN
gs-4062	573	9	.	.	PUNCT
gs-4062	574	1	the	the	DET
gs-4062	574	2	non	non	ADJ
gs-4062	574	3	-	-	ADJ
gs-4062	574	4	nucleoside	nucleoside	ADJ
gs-4062	574	5	reverse	reverse	ADJ
gs-4062	574	6	transcriptase	transcriptase	NOUN
gs-4062	574	7	inhibitors	inhibitor	NOUN
gs-4062	574	8	constitute	constitute	VERB
gs-4062	574	9	another	another	DET
gs-4062	574	10	class	class	NOUN
gs-4062	574	11	targeting	target	VERB
gs-4062	574	12	the	the	DET
gs-4062	574	13	same	same	ADJ
gs-4062	574	14	enzyme	enzyme	NOUN
gs-4062	574	15	but	but	CCONJ
gs-4062	574	16	through	through	ADP
gs-4062	574	17	a	a	DET
gs-4062	574	18	fundamentally	fundamentally	ADV
gs-4062	574	19	different	different	ADJ
gs-4062	574	20	mechanism	mechanism	NOUN
gs-4062	574	21	.	.	PUNCT
gs-4062	575	1	instead	instead	ADV
gs-4062	575	2	of	of	ADP
gs-4062	575	3	mimicking	mimic	VERB
gs-4062	575	4	nucleosides	nucleoside	NOUN
gs-4062	575	5	,	,	PUNCT
gs-4062	575	6	these	these	PRON
gs-4062	575	7	are	be	AUX
gs-4062	575	8	small	small	ADJ
gs-4062	575	9	,	,	PUNCT
gs-4062	575	10	hydrophobic	hydrophobic	NOUN
gs-4062	575	11	molecules	molecule	NOUN
gs-4062	575	12	that	that	PRON
gs-4062	575	13	bind	bind	VERB
gs-4062	575	14	to	to	ADP
gs-4062	575	15	a	a	DET
gs-4062	575	16	distinct	distinct	ADJ
gs-4062	575	17	,	,	PUNCT
gs-4062	575	18	allosteric	allosteric	ADJ
gs-4062	575	19	pocket	pocket	NOUN
gs-4062	575	20	on	on	ADP
gs-4062	575	21	the	the	DET
gs-4062	575	22	reverse	reverse	ADJ
gs-4062	575	23	transcriptase	transcriptase	NOUN
gs-4062	575	24	enzyme	enzyme	NOUN
gs-4062	575	25	,	,	PUNCT
gs-4062	575	26	near	near	ADP
gs-4062	575	27	its	its	PRON
gs-4062	575	28	active	active	ADJ
gs-4062	575	29	site	site	NOUN
gs-4062	575	30	.	.	PUNCT
gs-4062	576	1	this	this	DET
gs-4062	576	2	binding	bind	VERB
gs-4062	576	3	induces	induce	VERB
gs-4062	576	4	a	a	DET
gs-4062	576	5	conformational	conformational	ADJ
gs-4062	576	6	change	change	NOUN
gs-4062	576	7	in	in	ADP
gs-4062	576	8	the	the	DET
gs-4062	576	9	enzyme	enzyme	NOUN
gs-4062	576	10	that	that	PRON
gs-4062	576	11	dramatically	dramatically	ADV
gs-4062	576	12	reduces	reduce	VERB
gs-4062	576	13	its	its	PRON
gs-4062	576	14	catalytic	catalytic	ADJ
gs-4062	576	15	activity	activity	NOUN
gs-4062	576	16	,	,	PUNCT
gs-4062	576	17	effectively	effectively	ADV
gs-4062	576	18	non	non	ADJ
gs-4062	576	19	-	-	ADJ
gs-4062	576	20	competitively	competitively	ADV
gs-4062	576	21	inhibiting	inhibit	VERB
gs-4062	576	22	its	its	PRON
gs-4062	576	23	function	function	NOUN
gs-4062	576	24	.	.	PUNCT
gs-4062	577	1	their	their	PRON
gs-4062	577	2	mechanism	mechanism	NOUN
gs-4062	577	3	is	be	AUX
gs-4062	577	4	highly	highly	ADV
gs-4062	577	5	specific	specific	ADJ
gs-4062	577	6	to	to	ADP
gs-4062	577	7	the	the	DET
gs-4062	577	8	hiv-1	hiv-1	X
gs-4062	577	9	reverse	reverse	ADJ
gs-4062	577	10	transcriptase	transcriptase	NOUN
gs-4062	577	11	.	.	PUNCT
gs-4062	578	1	agents	agent	NOUN
gs-4062	578	2	like	like	ADP
gs-4062	578	3	efavirenz	efavirenz	NOUN
gs-4062	578	4	,	,	PUNCT
gs-4062	578	5	rilpivirine	rilpivirine	NOUN
gs-4062	578	6	,	,	PUNCT
gs-4062	578	7	and	and	CCONJ
gs-4062	578	8	doravirine	doravirine	ADJ
gs-4062	578	9	belong	belong	VERB
gs-4062	578	10	to	to	ADP
gs-4062	578	11	this	this	DET
gs-4062	578	12	class	class	NOUN
gs-4062	578	13	.	.	PUNCT
gs-4062	579	1	protease	protease	NOUN
gs-4062	579	2	inhibitors	inhibitor	NOUN
gs-4062	579	3	represent	represent	VERB
gs-4062	579	4	a	a	DET
gs-4062	579	5	critical	critical	ADJ
gs-4062	579	6	advancement	advancement	NOUN
gs-4062	579	7	in	in	ADP
gs-4062	579	8	hiv	hiv	PROPN
gs-4062	579	9	therapy	therapy	NOUN
gs-4062	579	10	.	.	PUNCT
gs-4062	580	1	they	they	PRON
gs-4062	580	2	are	be	AUX
gs-4062	580	3	designed	design	VERB
gs-4062	580	4	to	to	PART
gs-4062	580	5	mimic	mimic	VERB
gs-4062	580	6	the	the	DET
gs-4062	580	7	peptide	peptide	ADJ
gs-4062	580	8	substrate	substrate	NOUN
gs-4062	580	9	of	of	ADP
gs-4062	580	10	the	the	DET
gs-4062	580	11	hiv	hiv	PROPN
gs-4062	580	12	protease	protease	NOUN
gs-4062	580	13	enzyme	enzyme	NOUN
gs-4062	580	14	,	,	PUNCT
gs-4062	580	15	binding	bind	VERB
gs-4062	580	16	directly	directly	ADV
gs-4062	580	17	to	to	ADP
gs-4062	580	18	its	its	PRON
gs-4062	580	19	active	active	ADJ
gs-4062	580	20	site	site	NOUN
gs-4062	580	21	and	and	CCONJ
gs-4062	580	22	preventing	prevent	VERB
gs-4062	580	23	it	it	PRON
gs-4062	580	24	from	from	ADP
gs-4062	580	25	cleaving	cleave	VERB
gs-4062	580	26	the	the	DET
gs-4062	580	27	viral	viral	ADJ
gs-4062	580	28	gag	gag	NOUN
gs-4062	580	29	and	and	CCONJ
gs-4062	580	30	gag	gag	NOUN
gs-4062	580	31	-	-	PUNCT
gs-4062	580	32	pol	pol	NOUN
gs-4062	580	33	polyproteins	polyprotein	NOUN
gs-4062	580	34	.	.	PUNCT
gs-4062	581	1	this	this	DET
gs-4062	581	2	results	result	VERB
gs-4062	581	3	in	in	ADP
gs-4062	581	4	the	the	DET
gs-4062	581	5	production	production	NOUN
gs-4062	581	6	georgian	georgian	NOUN
gs-4062	581	7	scientists/	scientists/	NUM
gs-4062	581	8	.	.	PUNCT
gs-4062	582	1	7	7	NUM
gs-4062	582	2	n	n	PRON
gs-4062	582	3	3	3	NUM
gs-4062	582	4	,	,	PUNCT
gs-4062	582	5	2025	2025	NUM
gs-4062	582	6	547	547	NUM
gs-4062	582	7	of	of	ADP
gs-4062	582	8	immature	immature	ADJ
gs-4062	582	9	,	,	PUNCT
gs-4062	582	10	non	non	ADJ
gs-4062	582	11	-	-	ADJ
gs-4062	582	12	infectious	infectious	ADJ
gs-4062	582	13	viral	viral	ADJ
gs-4062	582	14	particles	particle	NOUN
gs-4062	582	15	.	.	PUNCT
gs-4062	583	1	because	because	SCONJ
gs-4062	583	2	they	they	PRON
gs-4062	583	3	target	target	VERB
gs-4062	583	4	a	a	DET
gs-4062	583	5	later	later	ADJ
gs-4062	583	6	step	step	NOUN
gs-4062	583	7	in	in	ADP
gs-4062	583	8	the	the	DET
gs-4062	583	9	viral	viral	ADJ
gs-4062	583	10	life	life	NOUN
gs-4062	583	11	cycle	cycle	NOUN
gs-4062	583	12	,	,	PUNCT
gs-4062	583	13	they	they	PRON
gs-4062	583	14	are	be	AUX
gs-4062	583	15	highly	highly	ADV
gs-4062	583	16	effective	effective	ADJ
gs-4062	583	17	.	.	PUNCT
gs-4062	584	1	however	however	ADV
gs-4062	584	2	,	,	PUNCT
gs-4062	584	3	their	their	PRON
gs-4062	584	4	large	large	ADJ
gs-4062	584	5	molecular	molecular	ADJ
gs-4062	584	6	size	size	NOUN
gs-4062	584	7	and	and	CCONJ
gs-4062	584	8	complex	complex	ADJ
gs-4062	584	9	structure	structure	NOUN
gs-4062	584	10	can	can	AUX
gs-4062	584	11	present	present	VERB
gs-4062	584	12	challenges	challenge	NOUN
gs-4062	584	13	for	for	ADP
gs-4062	584	14	bioavailability	bioavailability	NOUN
gs-4062	584	15	and	and	CCONJ
gs-4062	584	16	drug	drug	NOUN
gs-4062	584	17	interactions	interaction	NOUN
gs-4062	584	18	.	.	PUNCT
gs-4062	585	1	this	this	DET
gs-4062	585	2	class	class	NOUN
gs-4062	585	3	includes	include	VERB
gs-4062	585	4	drugs	drug	NOUN
gs-4062	585	5	such	such	ADJ
gs-4062	585	6	as	as	ADP
gs-4062	585	7	darunavir	darunavir	PROPN
gs-4062	585	8	and	and	CCONJ
gs-4062	585	9	atazanavir	atazanavir	PROPN
gs-4062	585	10	,	,	PUNCT
gs-4062	585	11	which	which	PRON
gs-4062	585	12	are	be	AUX
gs-4062	585	13	often	often	ADV
gs-4062	585	14	pharmacologically	pharmacologically	ADV
gs-4062	585	15	enhanced	enhance	VERB
gs-4062	585	16	with	with	ADP
gs-4062	585	17	a	a	DET
gs-4062	585	18	pharmacokinetic	pharmacokinetic	ADJ
gs-4062	585	19	booster	booster	NOUN
gs-4062	585	20	.	.	PUNCT
gs-4062	586	1	integrase	integrase	NOUN
gs-4062	586	2	strand	strand	NOUN
gs-4062	586	3	transfer	transfer	NOUN
gs-4062	586	4	inhibitors	inhibitor	NOUN
gs-4062	586	5	are	be	AUX
gs-4062	586	6	among	among	ADP
gs-4062	586	7	the	the	DET
gs-4062	586	8	newest	new	ADJ
gs-4062	586	9	and	and	CCONJ
gs-4062	586	10	most	most	ADV
gs-4062	586	11	potent	potent	ADJ
gs-4062	586	12	classes	class	NOUN
gs-4062	586	13	.	.	PUNCT
gs-4062	587	1	they	they	PRON
gs-4062	587	2	specifically	specifically	ADV
gs-4062	587	3	inhibit	inhibit	VERB
gs-4062	587	4	the	the	DET
gs-4062	587	5	integrase	integrase	NOUN
gs-4062	587	6	enzyme	enzyme	NOUN
gs-4062	587	7	,	,	PUNCT
gs-4062	587	8	which	which	PRON
gs-4062	587	9	is	be	AUX
gs-4062	587	10	responsible	responsible	ADJ
gs-4062	587	11	for	for	ADP
gs-4062	587	12	inserting	insert	VERB
gs-4062	587	13	viral	viral	ADJ
gs-4062	587	14	dna	dna	NOUN
gs-4062	587	15	into	into	ADP
gs-4062	587	16	the	the	DET
gs-4062	587	17	host	host	NOUN
gs-4062	587	18	genome	genome	NOUN
gs-4062	587	19	.	.	PUNCT
gs-4062	588	1	instis	insti	NOUN
gs-4062	588	2	bind	bind	VERB
gs-4062	588	3	to	to	ADP
gs-4062	588	4	the	the	DET
gs-4062	588	5	active	active	ADJ
gs-4062	588	6	site	site	NOUN
gs-4062	588	7	of	of	ADP
gs-4062	588	8	integrase	integrase	NOUN
gs-4062	588	9	,	,	PUNCT
gs-4062	588	10	blocking	block	VERB
gs-4062	588	11	the	the	DET
gs-4062	588	12	strand	strand	NOUN
gs-4062	588	13	transfer	transfer	NOUN
gs-4062	588	14	step	step	NOUN
gs-4062	588	15	where	where	SCONJ
gs-4062	588	16	the	the	DET
gs-4062	588	17	viral	viral	ADJ
gs-4062	588	18	dna	dna	NOUN
gs-4062	588	19	is	be	AUX
gs-4062	588	20	covalently	covalently	ADV
gs-4062	588	21	joined	join	VERB
gs-4062	588	22	to	to	ADP
gs-4062	588	23	the	the	DET
gs-4062	588	24	host	host	NOUN
gs-4062	588	25	dna	dna	NOUN
gs-4062	588	26	.	.	PUNCT
gs-4062	589	1	by	by	ADP
gs-4062	589	2	preventing	prevent	VERB
gs-4062	589	3	integration	integration	NOUN
gs-4062	589	4	,	,	PUNCT
gs-4062	589	5	they	they	PRON
gs-4062	589	6	halt	halt	VERB
gs-4062	589	7	the	the	DET
gs-4062	589	8	establishment	establishment	NOUN
gs-4062	589	9	of	of	ADP
gs-4062	589	10	the	the	DET
gs-4062	589	11	permanent	permanent	ADJ
gs-4062	589	12	provirus	provirus	NOUN
gs-4062	589	13	.	.	PUNCT
gs-4062	590	1	their	their	PRON
gs-4062	590	2	excellent	excellent	ADJ
gs-4062	590	3	efficacy	efficacy	NOUN
gs-4062	590	4	,	,	PUNCT
gs-4062	590	5	tolerability	tolerability	NOUN
gs-4062	590	6	,	,	PUNCT
gs-4062	590	7	and	and	CCONJ
gs-4062	590	8	high	high	ADJ
gs-4062	590	9	genetic	genetic	ADJ
gs-4062	590	10	barrier	barrier	NOUN
gs-4062	590	11	to	to	ADP
gs-4062	590	12	resistance	resistance	NOUN
gs-4062	590	13	have	have	AUX
gs-4062	590	14	made	make	VERB
gs-4062	590	15	them	they	PRON
gs-4062	590	16	the	the	DET
gs-4062	590	17	cornerstone	cornerstone	NOUN
gs-4062	590	18	of	of	ADP
gs-4062	590	19	most	most	ADJ
gs-4062	590	20	first	first	ADJ
gs-4062	590	21	-	-	PUNCT
gs-4062	590	22	line	line	NOUN
gs-4062	590	23	regimens	regimen	NOUN
gs-4062	590	24	.	.	PUNCT
gs-4062	591	1	dolutegravir	dolutegravir	NOUN
gs-4062	591	2	,	,	PUNCT
gs-4062	591	3	bictegravir	bictegravir	PROPN
gs-4062	591	4	,	,	PUNCT
gs-4062	591	5	and	and	CCONJ
gs-4062	591	6	raltegravir	raltegravir	PROPN
gs-4062	591	7	are	be	AUX
gs-4062	591	8	key	key	ADJ
gs-4062	591	9	agents	agent	NOUN
gs-4062	591	10	in	in	ADP
gs-4062	591	11	this	this	DET
gs-4062	591	12	class	class	NOUN
gs-4062	591	13	.	.	PUNCT
gs-4062	592	1	entry	entry	NOUN
gs-4062	592	2	inhibitors	inhibitor	NOUN
gs-4062	592	3	encompass	encompass	VERB
gs-4062	592	4	agents	agent	NOUN
gs-4062	592	5	that	that	PRON
gs-4062	592	6	interfere	interfere	VERB
gs-4062	592	7	with	with	ADP
gs-4062	592	8	the	the	DET
gs-4062	592	9	process	process	NOUN
gs-4062	592	10	of	of	ADP
gs-4062	592	11	viral	viral	ADJ
gs-4062	592	12	attachment	attachment	NOUN
gs-4062	592	13	and	and	CCONJ
gs-4062	592	14	fusion	fusion	NOUN
gs-4062	592	15	.	.	PUNCT
gs-4062	593	1	this	this	DET
gs-4062	593	2	class	class	NOUN
gs-4062	593	3	is	be	AUX
gs-4062	593	4	further	far	ADV
gs-4062	593	5	subdivided	subdivide	VERB
gs-4062	593	6	.	.	PUNCT
gs-4062	594	1	ccr5	ccr5	NOUN
gs-4062	594	2	antagonists	antagonist	NOUN
gs-4062	594	3	,	,	PUNCT
gs-4062	594	4	like	like	ADP
gs-4062	594	5	maraviroc	maraviroc	NOUN
gs-4062	594	6	,	,	PUNCT
gs-4062	594	7	block	block	VERB
gs-4062	594	8	the	the	DET
gs-4062	594	9	ccr5	ccr5	NOUN
gs-4062	594	10	coreceptor	coreceptor	NOUN
gs-4062	594	11	on	on	ADP
gs-4062	594	12	the	the	DET
gs-4062	594	13	host	host	NOUN
gs-4062	594	14	cell	cell	NOUN
gs-4062	594	15	surface	surface	NOUN
gs-4062	594	16	,	,	PUNCT
gs-4062	594	17	preventing	prevent	VERB
gs-4062	594	18	the	the	DET
gs-4062	594	19	virus	virus	NOUN
gs-4062	594	20	from	from	ADP
gs-4062	594	21	engaging	engage	VERB
gs-4062	594	22	it	it	PRON
gs-4062	594	23	.	.	PUNCT
gs-4062	595	1	fusion	fusion	NOUN
gs-4062	595	2	inhibitors	inhibitor	NOUN
gs-4062	595	3	,	,	PUNCT
gs-4062	595	4	such	such	ADJ
gs-4062	595	5	as	as	ADP
gs-4062	595	6	enfuvirtide	enfuvirtide	ADJ
gs-4062	595	7	,	,	PUNCT
gs-4062	595	8	are	be	AUX
gs-4062	595	9	peptides	peptide	NOUN
gs-4062	595	10	that	that	PRON
gs-4062	595	11	bind	bind	VERB
gs-4062	595	12	to	to	ADP
gs-4062	595	13	the	the	DET
gs-4062	595	14	viral	viral	ADJ
gs-4062	595	15	gp41	gp41	PROPN
gs-4062	595	16	protein	protein	NOUN
gs-4062	595	17	,	,	PUNCT
gs-4062	595	18	preventing	prevent	VERB
gs-4062	595	19	the	the	DET
gs-4062	595	20	conformational	conformational	ADJ
gs-4062	595	21	changes	change	NOUN
gs-4062	595	22	required	require	VERB
gs-4062	595	23	for	for	ADP
gs-4062	595	24	the	the	DET
gs-4062	595	25	fusion	fusion	NOUN
gs-4062	595	26	of	of	ADP
gs-4062	595	27	the	the	DET
gs-4062	595	28	viral	viral	ADJ
gs-4062	595	29	and	and	CCONJ
gs-4062	595	30	cellular	cellular	ADJ
gs-4062	595	31	membranes	membrane	NOUN
gs-4062	595	32	.	.	PUNCT
gs-4062	596	1	lastly	lastly	ADV
gs-4062	596	2	,	,	PUNCT
gs-4062	596	3	post	post	ADJ
gs-4062	596	4	-	-	ADJ
gs-4062	596	5	attachment	attachment	ADJ
gs-4062	596	6	inhibitors	inhibitor	NOUN
gs-4062	596	7	like	like	ADP
gs-4062	596	8	ibalizumab	ibalizumab	NOUN
gs-4062	596	9	,	,	PUNCT
gs-4062	596	10	a	a	DET
gs-4062	596	11	monoclonal	monoclonal	NOUN
gs-4062	596	12	antibody	antibody	NOUN
gs-4062	596	13	,	,	PUNCT
gs-4062	596	14	bind	bind	VERB
gs-4062	596	15	to	to	ADP
gs-4062	596	16	the	the	DET
gs-4062	596	17	host	host	NOUN
gs-4062	596	18	cd4	cd4	PROPN
gs-4062	596	19	receptor	receptor	NOUN
gs-4062	596	20	,	,	PUNCT
gs-4062	596	21	sterically	sterically	ADV
gs-4062	596	22	hindering	hinder	VERB
gs-4062	596	23	the	the	DET
gs-4062	596	24	virus	virus	NOUN
gs-4062	596	25	from	from	ADP
gs-4062	596	26	engaging	engage	VERB
gs-4062	596	27	the	the	DET
gs-4062	596	28	coreceptor	coreceptor	NOUN
gs-4062	596	29	after	after	SCONJ
gs-4062	596	30	it	it	PRON
gs-4062	596	31	has	have	AUX
gs-4062	596	32	already	already	ADV
gs-4062	596	33	attached	attach	VERB
gs-4062	596	34	to	to	ADP
gs-4062	596	35	cd4	cd4	PROPN
gs-4062	596	36	.	.	PUNCT
gs-4062	597	1	a	a	DET
gs-4062	597	2	more	more	ADV
gs-4062	597	3	recent	recent	ADJ
gs-4062	597	4	addition	addition	NOUN
gs-4062	597	5	is	be	AUX
gs-4062	597	6	the	the	DET
gs-4062	597	7	pharmacokinetic	pharmacokinetic	ADJ
gs-4062	597	8	enhancers	enhancer	NOUN
gs-4062	597	9	,	,	PUNCT
gs-4062	597	10	which	which	PRON
gs-4062	597	11	are	be	AUX
gs-4062	597	12	not	not	PART
gs-4062	597	13	antiviral	antiviral	ADJ
gs-4062	597	14	themselves	themselves	PRON
gs-4062	597	15	but	but	CCONJ
gs-4062	597	16	are	be	AUX
gs-4062	597	17	crucial	crucial	ADJ
gs-4062	597	18	supporting	support	VERB
gs-4062	597	19	actors	actor	NOUN
gs-4062	597	20	.	.	PUNCT
gs-4062	598	1	drugs	drug	NOUN
gs-4062	598	2	like	like	ADP
gs-4062	598	3	cobicistat	cobicistat	NOUN
gs-4062	598	4	and	and	CCONJ
gs-4062	598	5	ritonavir	ritonavir	PRON
gs-4062	598	6	are	be	AUX
gs-4062	598	7	potent	potent	ADJ
gs-4062	598	8	inhibitors	inhibitor	NOUN
gs-4062	598	9	of	of	ADP
gs-4062	598	10	the	the	DET
gs-4062	598	11	cytochrome	cytochrome	NOUN
gs-4062	598	12	p450	p450	PROPN
gs-4062	598	13	3a4	3a4	NUM
gs-4062	598	14	enzyme	enzyme	NOUN
gs-4062	598	15	system	system	NOUN
gs-4062	598	16	in	in	ADP
gs-4062	598	17	the	the	DET
gs-4062	598	18	liver	liver	NOUN
gs-4062	598	19	and	and	CCONJ
gs-4062	598	20	gut	gut	NOUN
gs-4062	598	21	.	.	PUNCT
gs-4062	599	1	by	by	ADP
gs-4062	599	2	co	co	VERB
gs-4062	599	3	-	-	VERB
gs-4062	599	4	administering	administer	VERB
gs-4062	599	5	them	they	PRON
gs-4062	599	6	with	with	ADP
gs-4062	599	7	certain	certain	ADJ
gs-4062	599	8	protease	protease	NOUN
gs-4062	599	9	inhibitors	inhibitor	NOUN
gs-4062	599	10	and	and	CCONJ
gs-4062	599	11	integrase	integrase	VERB
gs-4062	599	12	inhibitors	inhibitor	NOUN
gs-4062	599	13	,	,	PUNCT
gs-4062	599	14	they	they	PRON
gs-4062	599	15	effectively	effectively	ADV
gs-4062	599	16	slow	slow	VERB
gs-4062	599	17	the	the	DET
gs-4062	599	18	metabolism	metabolism	NOUN
gs-4062	599	19	of	of	ADP
gs-4062	599	20	the	the	DET
gs-4062	599	21	active	active	ADJ
gs-4062	599	22	drug	drug	NOUN
gs-4062	599	23	,	,	PUNCT
gs-4062	599	24	boosting	boost	VERB
gs-4062	599	25	its	its	PRON
gs-4062	599	26	plasma	plasma	NOUN
gs-4062	599	27	concentration	concentration	NOUN
gs-4062	599	28	and	and	CCONJ
gs-4062	599	29	allowing	allow	VERB
gs-4062	599	30	for	for	ADP
gs-4062	599	31	less	less	ADV
gs-4062	599	32	frequent	frequent	ADJ
gs-4062	599	33	dosing	dose	VERB
gs-4062	599	34	and	and	CCONJ
gs-4062	599	35	improved	improved	ADJ
gs-4062	599	36	efficacy	efficacy	NOUN
gs-4062	599	37	.	.	PUNCT
gs-4062	600	1	finally	finally	ADV
gs-4062	600	2	,	,	PUNCT
gs-4062	600	3	the	the	DET
gs-4062	600	4	latest	late	ADJ
gs-4062	600	5	frontier	frontier	NOUN
gs-4062	600	6	is	be	AUX
gs-4062	600	7	represented	represent	VERB
gs-4062	600	8	by	by	ADP
gs-4062	600	9	long	long	ADV
gs-4062	600	10	-	-	PUNCT
gs-4062	600	11	acting	act	VERB
gs-4062	600	12	antiretroviral	antiretroviral	ADJ
gs-4062	600	13	agents	agent	NOUN
gs-4062	600	14	,	,	PUNCT
gs-4062	600	15	which	which	PRON
gs-4062	600	16	are	be	AUX
gs-4062	600	17	formulations	formulation	NOUN
gs-4062	600	18	of	of	ADP
gs-4062	600	19	existing	exist	VERB
gs-4062	600	20	drugs	drug	NOUN
gs-4062	600	21	designed	design	VERB
gs-4062	600	22	for	for	ADP
gs-4062	600	23	extended	extend	VERB
gs-4062	600	24	-	-	PUNCT
gs-4062	600	25	duration	duration	NOUN
gs-4062	600	26	action	action	NOUN
gs-4062	600	27	.	.	PUNCT
gs-4062	601	1	this	this	PRON
gs-4062	601	2	includes	include	VERB
gs-4062	601	3	long	long	ADV
gs-4062	601	4	-	-	PUNCT
gs-4062	601	5	acting	act	VERB
gs-4062	601	6	injectable	injectable	ADJ
gs-4062	601	7	formulations	formulation	NOUN
gs-4062	601	8	,	,	PUNCT
gs-4062	601	9	such	such	ADJ
gs-4062	601	10	as	as	ADP
gs-4062	601	11	cabotegravir	cabotegravir	NOUN
gs-4062	601	12	and	and	CCONJ
gs-4062	601	13	rilpivirine	rilpivirine	PROPN
gs-4062	601	14	,	,	PUNCT
gs-4062	601	15	administered	administer	VERB
gs-4062	601	16	every	every	DET
gs-4062	601	17	one	one	NUM
gs-4062	601	18	or	or	CCONJ
gs-4062	601	19	two	two	NUM
gs-4062	601	20	months	month	NOUN
gs-4062	601	21	,	,	PUNCT
gs-4062	601	22	which	which	PRON
gs-4062	601	23	represent	represent	VERB
gs-4062	601	24	a	a	DET
gs-4062	601	25	monumental	monumental	ADJ
gs-4062	601	26	shift	shift	NOUN
gs-4062	601	27	from	from	ADP
gs-4062	601	28	daily	daily	ADJ
gs-4062	601	29	oral	oral	ADJ
gs-4062	601	30	therapy	therapy	NOUN
gs-4062	601	31	to	to	ADP
gs-4062	601	32	episodic	episodic	ADJ
gs-4062	601	33	administration	administration	NOUN
gs-4062	601	34	,	,	PUNCT
gs-4062	601	35	offering	offer	VERB
gs-4062	601	36	a	a	DET
gs-4062	601	37	solution	solution	NOUN
gs-4062	601	38	to	to	ADP
gs-4062	601	39	challenges	challenge	NOUN
gs-4062	601	40	of	of	ADP
gs-4062	601	41	adherence	adherence	NOUN
gs-4062	601	42	and	and	CCONJ
gs-4062	601	43	stigma	stigma	NOUN
gs-4062	601	44	.	.	PUNCT
gs-4062	602	1	mechanism	mechanism	NOUN
gs-4062	602	2	of	of	ADP
gs-4062	602	3	action	action	NOUN
gs-4062	602	4	:	:	PUNCT
gs-4062	602	5	a	a	DET
gs-4062	602	6	molecular	molecular	ADJ
gs-4062	602	7	perspective	perspective	NOUN
gs-4062	602	8	delving	delve	VERB
gs-4062	602	9	deeper	deeply	ADV
gs-4062	602	10	into	into	ADP
gs-4062	602	11	the	the	DET
gs-4062	602	12	mechanism	mechanism	NOUN
gs-4062	602	13	of	of	ADP
gs-4062	602	14	action	action	NOUN
gs-4062	602	15	reveals	reveal	VERB
gs-4062	602	16	the	the	DET
gs-4062	602	17	exquisite	exquisite	ADJ
gs-4062	602	18	precision	precision	NOUN
gs-4062	602	19	of	of	ADP
gs-4062	602	20	modern	modern	ADJ
gs-4062	602	21	antiretroviral	antiretroviral	ADJ
gs-4062	602	22	drug	drug	NOUN
gs-4062	602	23	design	design	NOUN
gs-4062	602	24	.	.	PUNCT
gs-4062	603	1	for	for	ADP
gs-4062	603	2	instis	instis	PROPN
gs-4062	603	3	like	like	ADP
gs-4062	603	4	dolutegravir	dolutegravir	NOUN
gs-4062	603	5	,	,	PUNCT
gs-4062	603	6	the	the	DET
gs-4062	603	7	molecular	molecular	ADJ
gs-4062	603	8	interaction	interaction	NOUN
gs-4062	603	9	is	be	AUX
gs-4062	603	10	particularly	particularly	ADV
gs-4062	603	11	elegant	elegant	ADJ
gs-4062	603	12	.	.	PUNCT
gs-4062	604	1	the	the	DET
gs-4062	604	2	drug	drug	NOUN
gs-4062	604	3	's	's	PART
gs-4062	604	4	structure	structure	NOUN
gs-4062	604	5	features	feature	VERB
gs-4062	604	6	a	a	DET
gs-4062	604	7	key	key	ADJ
gs-4062	604	8	pharmacophore	pharmacophore	NOUN
gs-4062	604	9	that	that	PRON
gs-4062	604	10	chelates	chelate	VERB
gs-4062	604	11	the	the	DET
gs-4062	604	12	two	two	NUM
gs-4062	604	13	magnesium	magnesium	NOUN
gs-4062	604	14	ions	ion	NOUN
gs-4062	604	15	present	present	ADJ
gs-4062	604	16	in	in	ADP
gs-4062	604	17	the	the	DET
gs-4062	604	18	active	active	ADJ
gs-4062	604	19	site	site	NOUN
gs-4062	604	20	of	of	ADP
gs-4062	604	21	the	the	DET
gs-4062	604	22	integrase	integrase	NOUN
gs-4062	604	23	enzyme	enzyme	NOUN
gs-4062	604	24	.	.	PUNCT
gs-4062	605	1	this	this	DET
gs-4062	605	2	metal	metal	NOUN
gs-4062	605	3	chelation	chelation	NOUN
gs-4062	605	4	is	be	AUX
gs-4062	605	5	crucial	crucial	ADJ
gs-4062	605	6	,	,	PUNCT
gs-4062	605	7	as	as	SCONJ
gs-4062	605	8	these	these	DET
gs-4062	605	9	ions	ion	NOUN
gs-4062	605	10	are	be	AUX
gs-4062	605	11	essential	essential	ADJ
gs-4062	605	12	cofactors	cofactor	NOUN
gs-4062	605	13	for	for	ADP
gs-4062	605	14	the	the	DET
gs-4062	605	15	catalytic	catalytic	ADJ
gs-4062	605	16	activity	activity	NOUN
gs-4062	605	17	of	of	ADP
gs-4062	605	18	integrase	integrase	NOUN
gs-4062	605	19	.	.	PUNCT
gs-4062	606	1	by	by	ADP
gs-4062	606	2	occupying	occupy	VERB
gs-4062	606	3	this	this	DET
gs-4062	606	4	site	site	NOUN
gs-4062	606	5	and	and	CCONJ
gs-4062	606	6	mimicking	mimic	VERB
gs-4062	606	7	the	the	DET
gs-4062	606	8	transition	transition	NOUN
gs-4062	606	9	state	state	NOUN
gs-4062	606	10	of	of	ADP
gs-4062	606	11	the	the	DET
gs-4062	606	12	viral	viral	ADJ
gs-4062	606	13	dna	dna	NOUN
gs-4062	606	14	substrate	substrate	NOUN
gs-4062	606	15	,	,	PUNCT
gs-4062	606	16	the	the	DET
gs-4062	606	17	insti	insti	NOUN
gs-4062	606	18	effectively	effectively	ADV
gs-4062	606	19	plugs	plug	VERB
gs-4062	606	20	the	the	DET
gs-4062	606	21	active	active	ADJ
gs-4062	606	22	site	site	NOUN
gs-4062	606	23	,	,	PUNCT
gs-4062	606	24	making	make	VERB
gs-4062	606	25	it	it	PRON
gs-4062	606	26	impossible	impossible	ADJ
gs-4062	606	27	for	for	SCONJ
gs-4062	606	28	the	the	DET
gs-4062	606	29	enzyme	enzyme	NOUN
gs-4062	606	30	to	to	PART
gs-4062	606	31	perform	perform	VERB
gs-4062	606	32	the	the	DET
gs-4062	606	33	nucleophilic	nucleophilic	ADJ
gs-4062	606	34	attack	attack	NOUN
gs-4062	606	35	on	on	ADP
gs-4062	606	36	the	the	DET
gs-4062	606	37	host	host	NOUN
gs-4062	606	38	dna	dna	NOUN
gs-4062	606	39	that	that	PRON
gs-4062	606	40	is	be	AUX
gs-4062	606	41	required	require	VERB
gs-4062	606	42	for	for	ADP
gs-4062	606	43	integration	integration	NOUN
gs-4062	606	44	.	.	PUNCT
gs-4062	607	1	the	the	DET
gs-4062	607	2	strength	strength	NOUN
gs-4062	607	3	of	of	ADP
gs-4062	607	4	this	this	DET
gs-4062	607	5	binding	bind	VERB
gs-4062	607	6	and	and	CCONJ
gs-4062	607	7	the	the	DET
gs-4062	607	8	specific	specific	ADJ
gs-4062	607	9	geometry	geometry	NOUN
gs-4062	607	10	of	of	ADP
gs-4062	607	11	the	the	DET
gs-4062	607	12	interaction	interaction	NOUN
gs-4062	607	13	contribute	contribute	VERB
gs-4062	607	14	to	to	ADP
gs-4062	607	15	the	the	DET
gs-4062	607	16	drug	drug	NOUN
gs-4062	607	17	's	's	PART
gs-4062	607	18	potency	potency	NOUN
gs-4062	607	19	and	and	CCONJ
gs-4062	607	20	its	its	PRON
gs-4062	607	21	high	high	ADJ
gs-4062	607	22	barrier	barrier	NOUN
gs-4062	607	23	to	to	ADP
gs-4062	607	24	resistance	resistance	NOUN
gs-4062	607	25	;	;	PUNCT
gs-4062	607	26	displacing	displace	VERB
gs-4062	607	27	such	such	DET
gs-4062	607	28	a	a	DET
gs-4062	607	29	tightly	tightly	ADV
gs-4062	607	30	bound	bind	VERB
gs-4062	607	31	molecule	molecule	NOUN
gs-4062	607	32	requires	require	VERB
gs-4062	607	33	significant	significant	ADJ
gs-4062	607	34	structural	structural	ADJ
gs-4062	607	35	changes	change	NOUN
gs-4062	607	36	to	to	ADP
gs-4062	607	37	the	the	DET
gs-4062	607	38	enzyme	enzyme	NOUN
gs-4062	607	39	,	,	PUNCT
gs-4062	607	40	which	which	PRON
gs-4062	607	41	often	often	ADV
gs-4062	607	42	come	come	VERB
gs-4062	607	43	at	at	ADP
gs-4062	607	44	a	a	DET
gs-4062	607	45	cost	cost	NOUN
gs-4062	607	46	to	to	ADP
gs-4062	607	47	viral	viral	ADJ
gs-4062	607	48	fitness	fitness	NOUN
gs-4062	607	49	.	.	PUNCT
gs-4062	608	1	the	the	DET
gs-4062	608	2	mechanism	mechanism	NOUN
gs-4062	608	3	of	of	ADP
gs-4062	608	4	newer	new	ADJ
gs-4062	608	5	pharmacoenhancers	pharmacoenhancer	NOUN
gs-4062	608	6	like	like	ADP
gs-4062	608	7	cobicistat	cobicistat	NOUN
gs-4062	608	8	illustrates	illustrate	VERB
gs-4062	608	9	a	a	DET
gs-4062	608	10	sophisticated	sophisticated	ADJ
gs-4062	608	11	understanding	understanding	NOUN
gs-4062	608	12	of	of	ADP
gs-4062	608	13	clinical	clinical	ADJ
gs-4062	608	14	pharmacology	pharmacology	NOUN
gs-4062	608	15	.	.	PUNCT
gs-4062	609	1	unlike	unlike	ADP
gs-4062	609	2	ritonavir	ritonavir	PROPN
gs-4062	609	3	,	,	PUNCT
gs-4062	609	4	which	which	PRON
gs-4062	609	5	has	have	VERB
gs-4062	609	6	some	some	DET
gs-4062	609	7	antiviral	antiviral	ADJ
gs-4062	609	8	activity	activity	NOUN
gs-4062	609	9	of	of	ADP
gs-4062	609	10	its	its	PRON
gs-4062	609	11	georgian	georgian	NOUN
gs-4062	609	12	scientists/	scientists/	NUM
gs-4062	609	13	.	.	PUNCT
gs-4062	610	1	7	7	NUM
gs-4062	610	2	n	n	PRON
gs-4062	610	3	3	3	NUM
gs-4062	610	4	,	,	PUNCT
gs-4062	610	5	2025	2025	NUM
gs-4062	610	6	548	548	NUM
gs-4062	610	7	own	own	ADJ
gs-4062	610	8	,	,	PUNCT
gs-4062	610	9	cobicistat	cobicistat	NOUN
gs-4062	610	10	was	be	AUX
gs-4062	610	11	designed	design	VERB
gs-4062	610	12	purely	purely	ADV
gs-4062	610	13	as	as	ADP
gs-4062	610	14	a	a	DET
gs-4062	610	15	pharmacokinetic	pharmacokinetic	ADJ
gs-4062	610	16	booster	booster	NOUN
gs-4062	610	17	.	.	PUNCT
gs-4062	611	1	it	it	PRON
gs-4062	611	2	is	be	AUX
gs-4062	611	3	a	a	DET
gs-4062	611	4	mechanism	mechanism	NOUN
gs-4062	611	5	-	-	PUNCT
gs-4062	611	6	based	base	VERB
gs-4062	611	7	inhibitor	inhibitor	NOUN
gs-4062	611	8	of	of	ADP
gs-4062	611	9	cyp3a4	cyp3a4	PROPN
gs-4062	611	10	.	.	PUNCT
gs-4062	612	1	it	it	PRON
gs-4062	612	2	is	be	AUX
gs-4062	612	3	metabolized	metabolize	VERB
gs-4062	612	4	by	by	ADP
gs-4062	612	5	the	the	DET
gs-4062	612	6	enzyme	enzyme	NOUN
gs-4062	612	7	into	into	ADP
gs-4062	612	8	a	a	DET
gs-4062	612	9	reactive	reactive	ADJ
gs-4062	612	10	intermediate	intermediate	NOUN
gs-4062	612	11	that	that	PRON
gs-4062	612	12	forms	form	VERB
gs-4062	612	13	a	a	DET
gs-4062	612	14	tight	tight	ADJ
gs-4062	612	15	,	,	PUNCT
gs-4062	612	16	stable	stable	ADJ
gs-4062	612	17	,	,	PUNCT
gs-4062	612	18	and	and	CCONJ
gs-4062	612	19	virtually	virtually	ADV
gs-4062	612	20	irreversible	irreversible	ADJ
gs-4062	612	21	covalent	covalent	NOUN
gs-4062	612	22	bond	bond	NOUN
gs-4062	612	23	with	with	ADP
gs-4062	612	24	the	the	DET
gs-4062	612	25	heme	heme	NOUN
gs-4062	612	26	moiety	moiety	NOUN
gs-4062	612	27	within	within	ADP
gs-4062	612	28	the	the	DET
gs-4062	612	29	cyp3a4	cyp3a4	PROPN
gs-4062	612	30	active	active	ADJ
gs-4062	612	31	site	site	NOUN
gs-4062	612	32	.	.	PUNCT
gs-4062	613	1	this	this	PRON
gs-4062	613	2	permanently	permanently	ADV
gs-4062	613	3	inactivates	inactivate	VERB
gs-4062	613	4	the	the	DET
gs-4062	613	5	enzyme	enzyme	NOUN
gs-4062	613	6	molecule	molecule	NOUN
gs-4062	613	7	for	for	ADP
gs-4062	613	8	the	the	DET
gs-4062	613	9	remainder	remainder	NOUN
gs-4062	613	10	of	of	ADP
gs-4062	613	11	its	its	PRON
gs-4062	613	12	lifespan	lifespan	NOUN
gs-4062	613	13	.	.	PUNCT
gs-4062	614	1	the	the	DET
gs-4062	614	2	body	body	NOUN
gs-4062	614	3	must	must	AUX
gs-4062	614	4	then	then	ADV
gs-4062	614	5	synthesize	synthesize	VERB
gs-4062	614	6	new	new	ADJ
gs-4062	614	7	cyp3a4	cyp3a4	NOUN
gs-4062	614	8	protein	protein	NOUN
gs-4062	614	9	to	to	PART
gs-4062	614	10	restore	restore	VERB
gs-4062	614	11	metabolic	metabolic	NOUN
gs-4062	614	12	activity	activity	NOUN
gs-4062	614	13	,	,	PUNCT
gs-4062	614	14	a	a	DET
gs-4062	614	15	process	process	NOUN
gs-4062	614	16	that	that	PRON
gs-4062	614	17	can	can	AUX
gs-4062	614	18	take	take	VERB
gs-4062	614	19	several	several	ADJ
gs-4062	614	20	days	day	NOUN
gs-4062	614	21	.	.	PUNCT
gs-4062	615	1	this	this	DET
gs-4062	615	2	profound	profound	ADJ
gs-4062	615	3	and	and	CCONJ
gs-4062	615	4	long	long	ADV
gs-4062	615	5	-	-	PUNCT
gs-4062	615	6	lasting	last	VERB
gs-4062	615	7	inhibition	inhibition	NOUN
gs-4062	615	8	provides	provide	VERB
gs-4062	615	9	a	a	DET
gs-4062	615	10	stable	stable	ADJ
gs-4062	615	11	and	and	CCONJ
gs-4062	615	12	predictable	predictable	ADJ
gs-4062	615	13	boosting	boost	VERB
gs-4062	615	14	effect	effect	NOUN
gs-4062	615	15	for	for	ADP
gs-4062	615	16	the	the	DET
gs-4062	615	17	co	co	ADJ
gs-4062	615	18	-	-	ADJ
gs-4062	615	19	administered	administered	ADJ
gs-4062	615	20	drug	drug	NOUN
gs-4062	615	21	,	,	PUNCT
gs-4062	615	22	improving	improve	VERB
gs-4062	615	23	the	the	DET
gs-4062	615	24	therapeutic	therapeutic	ADJ
gs-4062	615	25	profile	profile	NOUN
gs-4062	615	26	and	and	CCONJ
gs-4062	615	27	simplifying	simplify	VERB
gs-4062	615	28	dosing	dose	VERB
gs-4062	615	29	.	.	PUNCT
gs-4062	616	1	for	for	ADP
gs-4062	616	2	attachment	attachment	NOUN
gs-4062	616	3	inhibitors	inhibitor	NOUN
gs-4062	616	4	like	like	ADP
gs-4062	616	5	fostemsavir	fostemsavir	PROPN
gs-4062	616	6	,	,	PUNCT
gs-4062	616	7	a	a	DET
gs-4062	616	8	prodrug	prodrug	NOUN
gs-4062	616	9	of	of	ADP
gs-4062	616	10	temsavir	temsavir	PROPN
gs-4062	616	11	,	,	PUNCT
gs-4062	616	12	the	the	DET
gs-4062	616	13	mechanism	mechanism	NOUN
gs-4062	616	14	involves	involve	VERB
gs-4062	616	15	targeting	target	VERB
gs-4062	616	16	the	the	DET
gs-4062	616	17	viral	viral	ADJ
gs-4062	616	18	envelope	envelope	NOUN
gs-4062	616	19	glycoprotein	glycoprotein	NOUN
gs-4062	616	20	gp120	gp120	PROPN
gs-4062	616	21	.	.	PUNCT
gs-4062	617	1	temsavir	temsavir	PROPN
gs-4062	617	2	binds	bind	VERB
gs-4062	617	3	to	to	ADP
gs-4062	617	4	a	a	DET
gs-4062	617	5	conserved	conserved	ADJ
gs-4062	617	6	region	region	NOUN
gs-4062	617	7	on	on	ADP
gs-4062	617	8	gp120	gp120	PROPN
gs-4062	617	9	,	,	PUNCT
gs-4062	617	10	stabilizing	stabilize	VERB
gs-4062	617	11	it	it	PRON
gs-4062	617	12	in	in	ADP
gs-4062	617	13	a	a	DET
gs-4062	617	14	conformation	conformation	NOUN
gs-4062	617	15	that	that	PRON
gs-4062	617	16	is	be	AUX
gs-4062	617	17	unable	unable	ADJ
gs-4062	617	18	to	to	PART
gs-4062	617	19	undergo	undergo	VERB
gs-4062	617	20	the	the	DET
gs-4062	617	21	necessary	necessary	ADJ
gs-4062	617	22	rearrangements	rearrangement	NOUN
gs-4062	617	23	for	for	ADP
gs-4062	617	24	successful	successful	ADJ
gs-4062	617	25	engagement	engagement	NOUN
gs-4062	617	26	with	with	ADP
gs-4062	617	27	the	the	DET
gs-4062	617	28	cd4	cd4	PROPN
gs-4062	617	29	receptor	receptor	NOUN
gs-4062	617	30	.	.	PUNCT
gs-4062	618	1	this	this	PRON
gs-4062	618	2	is	be	AUX
gs-4062	618	3	a	a	DET
gs-4062	618	4	unique	unique	ADJ
gs-4062	618	5	approach	approach	NOUN
gs-4062	618	6	as	as	SCONJ
gs-4062	618	7	it	it	PRON
gs-4062	618	8	targets	target	VERB
gs-4062	618	9	a	a	DET
gs-4062	618	10	viral	viral	ADJ
gs-4062	618	11	protein	protein	NOUN
gs-4062	618	12	rather	rather	ADV
gs-4062	618	13	than	than	ADP
gs-4062	618	14	a	a	DET
gs-4062	618	15	host	host	NOUN
gs-4062	618	16	protein	protein	NOUN
gs-4062	618	17	,	,	PUNCT
gs-4062	618	18	but	but	CCONJ
gs-4062	618	19	it	it	PRON
gs-4062	618	20	does	do	VERB
gs-4062	618	21	so	so	ADV
gs-4062	618	22	at	at	ADP
gs-4062	618	23	a	a	DET
gs-4062	618	24	step	step	NOUN
gs-4062	618	25	prior	prior	ADV
gs-4062	618	26	to	to	ADP
gs-4062	618	27	host	host	NOUN
gs-4062	618	28	cell	cell	NOUN
gs-4062	618	29	engagement	engagement	NOUN
gs-4062	618	30	,	,	PUNCT
gs-4062	618	31	offering	offer	VERB
gs-4062	618	32	a	a	DET
gs-4062	618	33	valuable	valuable	ADJ
gs-4062	618	34	option	option	NOUN
gs-4062	618	35	for	for	ADP
gs-4062	618	36	highly	highly	ADV
gs-4062	618	37	treatment	treatment	NOUN
gs-4062	618	38	-	-	PUNCT
gs-4062	618	39	experienced	experience	VERB
gs-4062	618	40	patients	patient	NOUN
gs-4062	618	41	with	with	ADP
gs-4062	618	42	multidrug	multidrug	NOUN
gs-4062	618	43	-	-	PUNCT
gs-4062	618	44	resistant	resistant	ADJ
gs-4062	618	45	virus	virus	NOUN
gs-4062	618	46	.	.	PUNCT
gs-4062	619	1	pharmacology	pharmacology	NOUN
gs-4062	619	2	:	:	PUNCT
gs-4062	619	3	absorption	absorption	NOUN
gs-4062	619	4	,	,	PUNCT
gs-4062	619	5	distribution	distribution	NOUN
gs-4062	619	6	,	,	PUNCT
gs-4062	619	7	metabolism	metabolism	NOUN
gs-4062	619	8	,	,	PUNCT
gs-4062	619	9	and	and	CCONJ
gs-4062	619	10	excretion	excretion	VERB
gs-4062	619	11	the	the	DET
gs-4062	619	12	pharmacological	pharmacological	ADJ
gs-4062	619	13	profile	profile	NOUN
gs-4062	619	14	of	of	ADP
gs-4062	619	15	each	each	DET
gs-4062	619	16	antiretroviral	antiretroviral	ADJ
gs-4062	619	17	drug	drug	NOUN
gs-4062	619	18	dictates	dictate	VERB
gs-4062	619	19	its	its	PRON
gs-4062	619	20	dosing	dose	VERB
gs-4062	619	21	schedule	schedule	NOUN
gs-4062	619	22	,	,	PUNCT
gs-4062	619	23	potential	potential	NOUN
gs-4062	619	24	for	for	ADP
gs-4062	619	25	drug	drug	NOUN
gs-4062	619	26	interactions	interaction	NOUN
gs-4062	619	27	,	,	PUNCT
gs-4062	619	28	and	and	CCONJ
gs-4062	619	29	side	side	ADJ
gs-4062	619	30	effect	effect	NOUN
gs-4062	619	31	profile	profile	NOUN
gs-4062	619	32	.	.	PUNCT
gs-4062	620	1	absorption	absorption	NOUN
gs-4062	620	2	for	for	ADP
gs-4062	620	3	most	most	ADJ
gs-4062	620	4	oral	oral	ADJ
gs-4062	620	5	agents	agent	NOUN
gs-4062	620	6	can	can	AUX
gs-4062	620	7	be	be	AUX
gs-4062	620	8	influenced	influence	VERB
gs-4062	620	9	by	by	ADP
gs-4062	620	10	gastric	gastric	ADJ
gs-4062	620	11	ph	ph	NOUN
gs-4062	620	12	and	and	CCONJ
gs-4062	620	13	food	food	NOUN
gs-4062	620	14	.	.	PUNCT
gs-4062	621	1	some	some	DET
gs-4062	621	2	drugs	drug	NOUN
gs-4062	621	3	,	,	PUNCT
gs-4062	621	4	like	like	ADP
gs-4062	621	5	rilpivirine	rilpivirine	NOUN
gs-4062	621	6	,	,	PUNCT
gs-4062	621	7	require	require	VERB
gs-4062	621	8	an	an	DET
gs-4062	621	9	acidic	acidic	ADJ
gs-4062	621	10	environment	environment	NOUN
gs-4062	621	11	for	for	ADP
gs-4062	621	12	optimal	optimal	ADJ
gs-4062	621	13	absorption	absorption	NOUN
gs-4062	621	14	,	,	PUNCT
gs-4062	621	15	and	and	CCONJ
gs-4062	621	16	their	their	PRON
gs-4062	621	17	bioavailability	bioavailability	NOUN
gs-4062	621	18	can	can	AUX
gs-4062	621	19	be	be	AUX
gs-4062	621	20	significantly	significantly	ADV
gs-4062	621	21	reduced	reduce	VERB
gs-4062	621	22	by	by	ADP
gs-4062	621	23	concomitant	concomitant	ADJ
gs-4062	621	24	use	use	NOUN
gs-4062	621	25	of	of	ADP
gs-4062	621	26	proton	proton	NOUN
gs-4062	621	27	-	-	PUNCT
gs-4062	621	28	pump	pump	NOUN
gs-4062	621	29	inhibitors	inhibitor	NOUN
gs-4062	621	30	or	or	CCONJ
gs-4062	621	31	h2	h2	NOUN
gs-4062	621	32	-	-	PUNCT
gs-4062	621	33	receptor	receptor	NOUN
gs-4062	621	34	antagonists	antagonist	NOUN
gs-4062	621	35	.	.	PUNCT
gs-4062	622	1	others	other	NOUN
gs-4062	622	2	,	,	PUNCT
gs-4062	622	3	such	such	ADJ
gs-4062	622	4	as	as	ADP
gs-4062	622	5	efavirenz	efavirenz	NOUN
gs-4062	622	6	,	,	PUNCT
gs-4062	622	7	have	have	VERB
gs-4062	622	8	better	well	ADJ
gs-4062	622	9	tolerability	tolerability	NOUN
gs-4062	622	10	when	when	SCONJ
gs-4062	622	11	taken	take	VERB
gs-4062	622	12	on	on	ADP
gs-4062	622	13	an	an	DET
gs-4062	622	14	empty	empty	ADJ
gs-4062	622	15	stomach	stomach	NOUN
gs-4062	622	16	,	,	PUNCT
gs-4062	622	17	while	while	SCONJ
gs-4062	622	18	drugs	drug	NOUN
gs-4062	622	19	like	like	ADP
gs-4062	622	20	ritonavir	ritonavir	PROPN
gs-4062	622	21	-	-	PUNCT
gs-4062	622	22	boosted	boost	VERB
gs-4062	622	23	darunavir	darunavir	PROPN
gs-4062	622	24	require	require	VERB
gs-4062	622	25	a	a	DET
gs-4062	622	26	meal	meal	NOUN
gs-4062	622	27	to	to	PART
gs-4062	622	28	enhance	enhance	VERB
gs-4062	622	29	absorption	absorption	NOUN
gs-4062	622	30	and	and	CCONJ
gs-4062	622	31	minimize	minimize	VERB
gs-4062	622	32	gastrointestinal	gastrointestinal	ADJ
gs-4062	622	33	upset	upset	ADJ
gs-4062	622	34	.	.	PUNCT
gs-4062	623	1	distribution	distribution	NOUN
gs-4062	623	2	is	be	AUX
gs-4062	623	3	a	a	DET
gs-4062	623	4	critical	critical	ADJ
gs-4062	623	5	factor	factor	NOUN
gs-4062	623	6	,	,	PUNCT
gs-4062	623	7	particularly	particularly	ADV
gs-4062	623	8	for	for	ADP
gs-4062	623	9	drugs	drug	NOUN
gs-4062	623	10	intended	intend	VERB
gs-4062	623	11	to	to	PART
gs-4062	623	12	target	target	VERB
gs-4062	623	13	viral	viral	ADJ
gs-4062	623	14	reservoirs	reservoir	NOUN
gs-4062	623	15	or	or	CCONJ
gs-4062	623	16	prevent	prevent	VERB
gs-4062	623	17	infection	infection	NOUN
gs-4062	623	18	in	in	ADP
gs-4062	623	19	sanctuary	sanctuary	ADJ
gs-4062	623	20	sites	site	NOUN
gs-4062	623	21	like	like	ADP
gs-4062	623	22	the	the	DET
gs-4062	623	23	central	central	ADJ
gs-4062	623	24	nervous	nervous	ADJ
gs-4062	623	25	system	system	NOUN
gs-4062	623	26	and	and	CCONJ
gs-4062	623	27	the	the	DET
gs-4062	623	28	genital	genital	ADJ
gs-4062	623	29	tract	tract	NOUN
gs-4062	623	30	.	.	PUNCT
gs-4062	624	1	the	the	DET
gs-4062	624	2	ability	ability	NOUN
gs-4062	624	3	of	of	ADP
gs-4062	624	4	a	a	DET
gs-4062	624	5	drug	drug	NOUN
gs-4062	624	6	to	to	PART
gs-4062	624	7	penetrate	penetrate	VERB
gs-4062	624	8	these	these	DET
gs-4062	624	9	compartments	compartment	NOUN
gs-4062	624	10	is	be	AUX
gs-4062	624	11	determined	determine	VERB
gs-4062	624	12	by	by	ADP
gs-4062	624	13	its	its	PRON
gs-4062	624	14	molecular	molecular	ADJ
gs-4062	624	15	size	size	NOUN
gs-4062	624	16	,	,	PUNCT
gs-4062	624	17	lipophilicity	lipophilicity	NOUN
gs-4062	624	18	,	,	PUNCT
gs-4062	624	19	and	and	CCONJ
gs-4062	624	20	its	its	PRON
gs-4062	624	21	affinity	affinity	NOUN
gs-4062	624	22	for	for	ADP
gs-4062	624	23	drug	drug	NOUN
gs-4062	624	24	transporters	transporter	NOUN
gs-4062	624	25	like	like	ADP
gs-4062	624	26	p	p	NOUN
gs-4062	624	27	-	-	PUNCT
gs-4062	624	28	glycoprotein	glycoprotein	NOUN
gs-4062	624	29	.	.	PUNCT
gs-4062	625	1	drugs	drug	NOUN
gs-4062	625	2	with	with	ADP
gs-4062	625	3	good	good	ADJ
gs-4062	625	4	cns	cns	NOUN
gs-4062	625	5	penetration	penetration	NOUN
gs-4062	625	6	,	,	PUNCT
gs-4062	625	7	such	such	ADJ
gs-4062	625	8	as	as	ADP
gs-4062	625	9	dolutegravir	dolutegravir	NOUN
gs-4062	625	10	and	and	CCONJ
gs-4062	625	11	abacavir	abacavir	PROPN
gs-4062	625	12	,	,	PUNCT
gs-4062	625	13	are	be	AUX
gs-4062	625	14	advantageous	advantageous	ADJ
gs-4062	625	15	as	as	SCONJ
gs-4062	625	16	they	they	PRON
gs-4062	625	17	can	can	AUX
gs-4062	625	18	suppress	suppress	VERB
gs-4062	625	19	viral	viral	ADJ
gs-4062	625	20	replication	replication	NOUN
gs-4062	625	21	in	in	ADP
gs-4062	625	22	the	the	DET
gs-4062	625	23	brain	brain	NOUN
gs-4062	625	24	,	,	PUNCT
gs-4062	625	25	potentially	potentially	ADV
gs-4062	625	26	improving	improve	VERB
gs-4062	625	27	neurocognitive	neurocognitive	ADJ
gs-4062	625	28	outcomes	outcome	NOUN
gs-4062	625	29	and	and	CCONJ
gs-4062	625	30	preventing	prevent	VERB
gs-4062	625	31	the	the	DET
gs-4062	625	32	establishment	establishment	NOUN
gs-4062	625	33	of	of	ADP
gs-4062	625	34	a	a	DET
gs-4062	625	35	reservoir	reservoir	NOUN
gs-4062	625	36	in	in	ADP
gs-4062	625	37	this	this	DET
gs-4062	625	38	protected	protect	VERB
gs-4062	625	39	site	site	NOUN
gs-4062	625	40	.	.	PUNCT
gs-4062	626	1	metabolism	metabolism	NOUN
gs-4062	626	2	is	be	AUX
gs-4062	626	3	perhaps	perhaps	ADV
gs-4062	626	4	the	the	DET
gs-4062	626	5	most	most	ADV
gs-4062	626	6	significant	significant	ADJ
gs-4062	626	7	source	source	NOUN
gs-4062	626	8	of	of	ADP
gs-4062	626	9	variation	variation	NOUN
gs-4062	626	10	and	and	CCONJ
gs-4062	626	11	potential	potential	ADJ
gs-4062	626	12	drug	drug	NOUN
gs-4062	626	13	interactions	interaction	NOUN
gs-4062	626	14	.	.	PUNCT
gs-4062	627	1	the	the	DET
gs-4062	627	2	majority	majority	NOUN
gs-4062	627	3	of	of	ADP
gs-4062	627	4	antiretroviral	antiretroviral	ADJ
gs-4062	627	5	drugs	drug	NOUN
gs-4062	627	6	are	be	AUX
gs-4062	627	7	metabolized	metabolize	VERB
gs-4062	627	8	by	by	ADP
gs-4062	627	9	the	the	DET
gs-4062	627	10	hepatic	hepatic	ADJ
gs-4062	627	11	cytochrome	cytochrome	NOUN
gs-4062	627	12	p450	p450	NUM
gs-4062	627	13	system	system	NOUN
gs-4062	627	14	,	,	PUNCT
gs-4062	627	15	predominantly	predominantly	ADV
gs-4062	627	16	the	the	DET
gs-4062	627	17	cyp3a4	cyp3a4	PROPN
gs-4062	627	18	isoenzyme	isoenzyme	NOUN
gs-4062	627	19	.	.	PUNCT
gs-4062	628	1	this	this	PRON
gs-4062	628	2	is	be	AUX
gs-4062	628	3	the	the	DET
gs-4062	628	4	basis	basis	NOUN
gs-4062	628	5	for	for	ADP
gs-4062	628	6	the	the	DET
gs-4062	628	7	action	action	NOUN
gs-4062	628	8	of	of	ADP
gs-4062	628	9	pharmacokinetic	pharmacokinetic	ADJ
gs-4062	628	10	enhancers	enhancer	NOUN
gs-4062	628	11	.	.	PUNCT
gs-4062	629	1	however	however	ADV
gs-4062	629	2	,	,	PUNCT
gs-4062	629	3	this	this	DET
gs-4062	629	4	shared	share	VERB
gs-4062	629	5	metabolic	metabolic	NOUN
gs-4062	629	6	pathway	pathway	NOUN
gs-4062	629	7	means	mean	VERB
gs-4062	629	8	that	that	SCONJ
gs-4062	629	9	antiretrovirals	antiretroviral	NOUN
gs-4062	629	10	can	can	AUX
gs-4062	629	11	interact	interact	VERB
gs-4062	629	12	with	with	ADP
gs-4062	629	13	a	a	DET
gs-4062	629	14	vast	vast	ADJ
gs-4062	629	15	array	array	NOUN
gs-4062	629	16	of	of	ADP
gs-4062	629	17	other	other	ADJ
gs-4062	629	18	medications	medication	NOUN
gs-4062	629	19	,	,	PUNCT
gs-4062	629	20	including	include	VERB
gs-4062	629	21	statins	statin	NOUN
gs-4062	629	22	,	,	PUNCT
gs-4062	629	23	anticoagulants	anticoagulant	NOUN
gs-4062	629	24	,	,	PUNCT
gs-4062	629	25	antidepressants	antidepressant	NOUN
gs-4062	629	26	,	,	PUNCT
gs-4062	629	27	and	and	CCONJ
gs-4062	629	28	recreational	recreational	ADJ
gs-4062	629	29	drugs	drug	NOUN
gs-4062	629	30	.	.	PUNCT
gs-4062	630	1	some	some	DET
gs-4062	630	2	drugs	drug	NOUN
gs-4062	630	3	,	,	PUNCT
gs-4062	630	4	like	like	ADP
gs-4062	630	5	efavirenz	efavirenz	NOUN
gs-4062	630	6	,	,	PUNCT
gs-4062	630	7	are	be	AUX
gs-4062	630	8	inducers	inducer	NOUN
gs-4062	630	9	of	of	ADP
gs-4062	630	10	cyp	cyp	ADJ
gs-4062	630	11	enzymes	enzyme	NOUN
gs-4062	630	12	,	,	PUNCT
gs-4062	630	13	leading	lead	VERB
gs-4062	630	14	to	to	ADP
gs-4062	630	15	reduced	reduced	ADJ
gs-4062	630	16	levels	level	NOUN
gs-4062	630	17	of	of	ADP
gs-4062	630	18	coadministered	coadministered	ADJ
gs-4062	630	19	drugs	drug	NOUN
gs-4062	630	20	,	,	PUNCT
gs-4062	630	21	while	while	SCONJ
gs-4062	630	22	others	other	NOUN
gs-4062	630	23	,	,	PUNCT
gs-4062	630	24	like	like	ADP
gs-4062	630	25	protease	protease	NOUN
gs-4062	630	26	inhibitors	inhibitor	NOUN
gs-4062	630	27	,	,	PUNCT
gs-4062	630	28	are	be	AUX
gs-4062	630	29	inhibitors	inhibitor	NOUN
gs-4062	630	30	,	,	PUNCT
gs-4062	630	31	leading	lead	VERB
gs-4062	630	32	to	to	ADP
gs-4062	630	33	increased	increase	VERB
gs-4062	630	34	levels	level	NOUN
gs-4062	630	35	.	.	PUNCT
gs-4062	631	1	non	non	ADJ
gs-4062	631	2	-	-	ADJ
gs-4062	631	3	nucleoside	nucleoside	ADJ
gs-4062	631	4	reverse	reverse	ADJ
gs-4062	631	5	transcriptase	transcriptase	NOUN
gs-4062	631	6	inhibitors	inhibitor	NOUN
gs-4062	631	7	and	and	CCONJ
gs-4062	631	8	integrase	integrase	VERB
gs-4062	631	9	inhibitors	inhibitor	NOUN
gs-4062	631	10	can	can	AUX
gs-4062	631	11	be	be	AUX
gs-4062	631	12	both	both	DET
gs-4062	631	13	inhibitors	inhibitor	NOUN
gs-4062	631	14	and	and	CCONJ
gs-4062	631	15	inducers	inducer	NOUN
gs-4062	631	16	of	of	ADP
gs-4062	631	17	various	various	ADJ
gs-4062	631	18	enzymes	enzyme	NOUN
gs-4062	631	19	and	and	CCONJ
gs-4062	631	20	transporters	transporter	NOUN
gs-4062	631	21	,	,	PUNCT
gs-4062	631	22	making	make	VERB
gs-4062	631	23	their	their	PRON
gs-4062	631	24	interaction	interaction	NOUN
gs-4062	631	25	profile	profile	NOUN
gs-4062	631	26	complex	complex	ADJ
gs-4062	631	27	.	.	PUNCT
gs-4062	632	1	a	a	DET
gs-4062	632	2	thorough	thorough	ADJ
gs-4062	632	3	review	review	NOUN
gs-4062	632	4	of	of	ADP
gs-4062	632	5	a	a	DET
gs-4062	632	6	patient	patient	NOUN
gs-4062	632	7	's	's	PART
gs-4062	632	8	complete	complete	ADJ
gs-4062	632	9	medication	medication	NOUN
gs-4062	632	10	list	list	NOUN
gs-4062	632	11	is	be	AUX
gs-4062	632	12	therefore	therefore	ADV
gs-4062	632	13	an	an	DET
gs-4062	632	14	absolute	absolute	ADJ
gs-4062	632	15	imperative	imperative	NOUN
gs-4062	632	16	before	before	ADP
gs-4062	632	17	initiating	initiate	VERB
gs-4062	632	18	or	or	CCONJ
gs-4062	632	19	modifying	modify	VERB
gs-4062	632	20	an	an	DET
gs-4062	632	21	antiretroviral	antiretroviral	ADJ
gs-4062	632	22	regimen	regiman	NOUN
gs-4062	632	23	.	.	PUNCT
gs-4062	633	1	excretion	excretion	NOUN
gs-4062	633	2	pathways	pathway	NOUN
gs-4062	633	3	also	also	ADV
gs-4062	633	4	vary	vary	VERB
gs-4062	633	5	.	.	PUNCT
gs-4062	634	1	most	most	ADJ
gs-4062	634	2	nrtis	nrtis	PROPN
gs-4062	634	3	are	be	AUX
gs-4062	634	4	renally	renally	ADV
gs-4062	634	5	eliminated	eliminate	VERB
gs-4062	634	6	,	,	PUNCT
gs-4062	634	7	necessitating	necessitate	VERB
gs-4062	634	8	dose	dose	NOUN
gs-4062	634	9	adjustment	adjustment	NOUN
gs-4062	634	10	in	in	ADP
gs-4062	634	11	patients	patient	NOUN
gs-4062	634	12	with	with	ADP
gs-4062	634	13	impaired	impaired	ADJ
gs-4062	634	14	renal	renal	ADJ
gs-4062	634	15	function	function	NOUN
gs-4062	634	16	.	.	PUNCT
gs-4062	635	1	in	in	ADP
gs-4062	635	2	contrast	contrast	NOUN
gs-4062	635	3	,	,	PUNCT
gs-4062	635	4	most	most	ADJ
gs-4062	635	5	protease	protease	NOUN
gs-4062	635	6	inhibitors	inhibitor	NOUN
gs-4062	635	7	,	,	PUNCT
gs-4062	635	8	nonnucleoside	nonnucleoside	ADV
gs-4062	635	9	reverse	reverse	ADJ
gs-4062	635	10	transcriptase	transcriptase	NOUN
gs-4062	635	11	inhibitors	inhibitor	NOUN
gs-4062	635	12	,	,	PUNCT
gs-4062	635	13	and	and	CCONJ
gs-4062	635	14	integrase	integrase	VERB
gs-4062	635	15	inhibitors	inhibitor	NOUN
gs-4062	635	16	are	be	AUX
gs-4062	635	17	primarily	primarily	ADV
gs-4062	635	18	metabolized	metabolize	VERB
gs-4062	635	19	and	and	CCONJ
gs-4062	635	20	georgian	georgian	NOUN
gs-4062	635	21	scientists/	scientists/	NUM
gs-4062	635	22	.	.	PUNCT
gs-4062	636	1	7	7	NUM
gs-4062	636	2	n	n	PRON
gs-4062	636	3	3	3	NUM
gs-4062	636	4	,	,	PUNCT
gs-4062	636	5	2025	2025	NUM
gs-4062	636	6	549	549	NUM
gs-4062	636	7	excreted	excrete	VERB
gs-4062	636	8	via	via	ADP
gs-4062	636	9	the	the	DET
gs-4062	636	10	feces	fece	NOUN
gs-4062	636	11	.	.	PUNCT
gs-4062	637	1	understanding	understand	VERB
gs-4062	637	2	these	these	DET
gs-4062	637	3	pathways	pathway	NOUN
gs-4062	637	4	is	be	AUX
gs-4062	637	5	essential	essential	ADJ
gs-4062	637	6	for	for	ADP
gs-4062	637	7	managing	manage	VERB
gs-4062	637	8	patients	patient	NOUN
gs-4062	637	9	with	with	ADP
gs-4062	637	10	organ	organ	NOUN
gs-4062	637	11	dysfunction	dysfunction	NOUN
gs-4062	637	12	and	and	CCONJ
gs-4062	637	13	for	for	ADP
gs-4062	637	14	anticipating	anticipate	VERB
gs-4062	637	15	potential	potential	ADJ
gs-4062	637	16	interactions	interaction	NOUN
gs-4062	637	17	with	with	ADP
gs-4062	637	18	other	other	ADJ
gs-4062	637	19	drugs	drug	NOUN
gs-4062	637	20	that	that	PRON
gs-4062	637	21	may	may	AUX
gs-4062	637	22	affect	affect	VERB
gs-4062	637	23	these	these	DET
gs-4062	637	24	elimination	elimination	NOUN
gs-4062	637	25	routes	route	NOUN
gs-4062	637	26	.	.	PUNCT
gs-4062	638	1	clinical	clinical	ADJ
gs-4062	638	2	use	use	NOUN
gs-4062	638	3	:	:	PUNCT
gs-4062	638	4	guidelines	guideline	NOUN
gs-4062	638	5	and	and	CCONJ
gs-4062	638	6	personalized	personalized	ADJ
gs-4062	638	7	medicine	medicine	NOUN
gs-4062	638	8	the	the	DET
gs-4062	638	9	clinical	clinical	ADJ
gs-4062	638	10	use	use	NOUN
gs-4062	638	11	of	of	ADP
gs-4062	638	12	antiretroviral	antiretroviral	ADJ
gs-4062	638	13	therapy	therapy	NOUN
gs-4062	638	14	is	be	AUX
gs-4062	638	15	guided	guide	VERB
gs-4062	638	16	by	by	ADP
gs-4062	638	17	robust	robust	ADJ
gs-4062	638	18	,	,	PUNCT
gs-4062	638	19	evidence	evidence	NOUN
gs-4062	638	20	-	-	PUNCT
gs-4062	638	21	based	base	VERB
gs-4062	638	22	guidelines	guideline	NOUN
gs-4062	638	23	issued	issue	VERB
gs-4062	638	24	by	by	ADP
gs-4062	638	25	international	international	ADJ
gs-4062	638	26	and	and	CCONJ
gs-4062	638	27	national	national	ADJ
gs-4062	638	28	bodies	body	NOUN
gs-4062	638	29	.	.	PUNCT
gs-4062	639	1	the	the	DET
gs-4062	639	2	universal	universal	ADJ
gs-4062	639	3	recommendation	recommendation	NOUN
gs-4062	639	4	is	be	AUX
gs-4062	639	5	to	to	PART
gs-4062	639	6	initiate	initiate	VERB
gs-4062	639	7	therapy	therapy	NOUN
gs-4062	639	8	in	in	ADP
gs-4062	639	9	all	all	DET
gs-4062	639	10	individuals	individual	NOUN
gs-4062	639	11	living	live	VERB
gs-4062	639	12	with	with	ADP
gs-4062	639	13	hiv	hiv	PROPN
gs-4062	639	14	,	,	PUNCT
gs-4062	639	15	regardless	regardless	ADV
gs-4062	639	16	of	of	ADP
gs-4062	639	17	cd4	cd4	PROPN
gs-4062	639	18	cell	cell	NOUN
gs-4062	639	19	count	count	NOUN
gs-4062	639	20	,	,	PUNCT
gs-4062	639	21	a	a	DET
gs-4062	639	22	strategy	strategy	NOUN
gs-4062	639	23	known	know	VERB
gs-4062	639	24	as	as	ADP
gs-4062	639	25	"	"	PUNCT
gs-4062	639	26	treatment	treatment	NOUN
gs-4062	639	27	for	for	ADP
gs-4062	639	28	all	all	PRON
gs-4062	639	29	.	.	PUNCT
gs-4062	639	30	"	"	PUNCT
gs-4062	640	1	this	this	DET
gs-4062	640	2	approach	approach	NOUN
gs-4062	640	3	is	be	AUX
gs-4062	640	4	founded	found	VERB
gs-4062	640	5	on	on	ADP
gs-4062	640	6	overwhelming	overwhelming	ADJ
gs-4062	640	7	evidence	evidence	NOUN
gs-4062	640	8	that	that	SCONJ
gs-4062	640	9	early	early	ADJ
gs-4062	640	10	treatment	treatment	NOUN
gs-4062	640	11	preserves	preserve	VERB
gs-4062	640	12	immune	immune	ADJ
gs-4062	640	13	function	function	NOUN
gs-4062	640	14	,	,	PUNCT
gs-4062	640	15	reduces	reduce	VERB
gs-4062	640	16	hiv	hiv	NOUN
gs-4062	640	17	-	-	PUNCT
gs-4062	640	18	associated	associate	VERB
gs-4062	640	19	complications	complication	NOUN
gs-4062	640	20	,	,	PUNCT
gs-4062	640	21	and	and	CCONJ
gs-4062	640	22	nearly	nearly	ADV
gs-4062	640	23	eliminates	eliminate	VERB
gs-4062	640	24	the	the	DET
gs-4062	640	25	risk	risk	NOUN
gs-4062	640	26	of	of	ADP
gs-4062	640	27	sexual	sexual	ADJ
gs-4062	640	28	transmission	transmission	NOUN
gs-4062	640	29	of	of	ADP
gs-4062	640	30	the	the	DET
gs-4062	640	31	virus	virus	NOUN
gs-4062	640	32	.	.	PUNCT
gs-4062	641	1	the	the	DET
gs-4062	641	2	choice	choice	NOUN
gs-4062	641	3	of	of	ADP
gs-4062	641	4	initial	initial	ADJ
gs-4062	641	5	regimen	regimen	NOUN
gs-4062	641	6	is	be	AUX
gs-4062	641	7	a	a	DET
gs-4062	641	8	nuanced	nuanced	ADJ
gs-4062	641	9	decision	decision	NOUN
gs-4062	641	10	,	,	PUNCT
gs-4062	641	11	moving	move	VERB
gs-4062	641	12	towards	towards	ADP
gs-4062	641	13	personalized	personalized	ADJ
gs-4062	641	14	medicine	medicine	NOUN
gs-4062	641	15	.	.	PUNCT
gs-4062	642	1	modern	modern	ADJ
gs-4062	642	2	first	first	ADJ
gs-4062	642	3	-	-	PUNCT
gs-4062	642	4	line	line	NOUN
gs-4062	642	5	regimens	regimen	NOUN
gs-4062	642	6	are	be	AUX
gs-4062	642	7	typically	typically	ADV
gs-4062	642	8	composed	compose	VERB
gs-4062	642	9	of	of	ADP
gs-4062	642	10	two	two	NUM
gs-4062	642	11	nucleoside	nucleoside	ADV
gs-4062	642	12	reverse	reverse	ADJ
gs-4062	642	13	transcriptase	transcriptase	NOUN
gs-4062	642	14	inhibitors	inhibitor	NOUN
gs-4062	642	15	acting	act	VERB
gs-4062	642	16	as	as	ADP
gs-4062	642	17	the	the	DET
gs-4062	642	18	pharmacological	pharmacological	ADJ
gs-4062	642	19	backbone	backbone	NOUN
gs-4062	642	20	,	,	PUNCT
gs-4062	642	21	plus	plus	CCONJ
gs-4062	642	22	a	a	DET
gs-4062	642	23	third	third	ADJ
gs-4062	642	24	agent	agent	NOUN
gs-4062	642	25	from	from	ADP
gs-4062	642	26	a	a	DET
gs-4062	642	27	more	more	ADV
gs-4062	642	28	potent	potent	ADJ
gs-4062	642	29	class	class	NOUN
gs-4062	642	30	,	,	PUNCT
gs-4062	642	31	most	most	ADV
gs-4062	642	32	commonly	commonly	ADV
gs-4062	642	33	an	an	DET
gs-4062	642	34	integrase	integrase	NOUN
gs-4062	642	35	strand	strand	NOUN
gs-4062	642	36	transfer	transfer	NOUN
gs-4062	642	37	inhibitor	inhibitor	NOUN
gs-4062	642	38	.	.	PUNCT
gs-4062	643	1	the	the	DET
gs-4062	643	2	fixed	fix	VERB
gs-4062	643	3	-	-	PUNCT
gs-4062	643	4	dose	dose	NOUN
gs-4062	643	5	combination	combination	NOUN
gs-4062	643	6	of	of	ADP
gs-4062	643	7	bictegravir	bictegravir	PROPN
gs-4062	643	8	,	,	PUNCT
gs-4062	643	9	emtricitabine	emtricitabine	NOUN
gs-4062	643	10	,	,	PUNCT
gs-4062	643	11	and	and	CCONJ
gs-4062	643	12	tenofovir	tenofovir	PROPN
gs-4062	643	13	alafenamide	alafenamide	PROPN
gs-4062	643	14	is	be	AUX
gs-4062	643	15	a	a	DET
gs-4062	643	16	single	single	ADJ
gs-4062	643	17	-	-	PUNCT
gs-4062	643	18	tablet	tablet	NOUN
gs-4062	643	19	regimen	regiman	NOUN
gs-4062	643	20	that	that	PRON
gs-4062	643	21	offers	offer	VERB
gs-4062	643	22	high	high	ADJ
gs-4062	643	23	potency	potency	NOUN
gs-4062	643	24	,	,	PUNCT
gs-4062	643	25	a	a	DET
gs-4062	643	26	high	high	ADJ
gs-4062	643	27	barrier	barrier	NOUN
gs-4062	643	28	to	to	ADP
gs-4062	643	29	resistance	resistance	NOUN
gs-4062	643	30	,	,	PUNCT
gs-4062	643	31	and	and	CCONJ
gs-4062	643	32	a	a	DET
gs-4062	643	33	favorable	favorable	ADJ
gs-4062	643	34	metabolic	metabolic	NOUN
gs-4062	643	35	profile	profile	NOUN
gs-4062	643	36	.	.	PUNCT
gs-4062	644	1	similarly	similarly	ADV
gs-4062	644	2	,	,	PUNCT
gs-4062	644	3	dolutegravir	dolutegravir	NOUN
gs-4062	644	4	combined	combine	VERB
gs-4062	644	5	with	with	ADP
gs-4062	644	6	lamivudine	lamivudine	NOUN
gs-4062	644	7	is	be	AUX
gs-4062	644	8	an	an	DET
gs-4062	644	9	effective	effective	ADJ
gs-4062	644	10	two	two	NUM
gs-4062	644	11	-	-	PUNCT
gs-4062	644	12	drug	drug	NOUN
gs-4062	644	13	regimen	regiman	NOUN
gs-4062	644	14	for	for	ADP
gs-4062	644	15	many	many	ADJ
gs-4062	644	16	patients	patient	NOUN
gs-4062	644	17	,	,	PUNCT
gs-4062	644	18	reducing	reduce	VERB
gs-4062	644	19	long	long	ADJ
gs-4062	644	20	-	-	PUNCT
gs-4062	644	21	term	term	NOUN
gs-4062	644	22	drug	drug	NOUN
gs-4062	644	23	exposure	exposure	NOUN
gs-4062	644	24	.	.	PUNCT
gs-4062	645	1	the	the	DET
gs-4062	645	2	selection	selection	NOUN
gs-4062	645	3	of	of	ADP
gs-4062	645	4	a	a	DET
gs-4062	645	5	regimen	regimen	NOUN
gs-4062	645	6	is	be	AUX
gs-4062	645	7	tailored	tailor	VERB
gs-4062	645	8	to	to	ADP
gs-4062	645	9	the	the	DET
gs-4062	645	10	individual	individual	ADJ
gs-4062	645	11	patient	patient	NOUN
gs-4062	645	12	.	.	PUNCT
gs-4062	646	1	factors	factor	NOUN
gs-4062	646	2	considered	consider	VERB
gs-4062	646	3	include	include	VERB
gs-4062	646	4	pre	pre	ADJ
gs-4062	646	5	-	-	ADJ
gs-4062	646	6	treatment	treatment	ADJ
gs-4062	646	7	drug	drug	NOUN
gs-4062	646	8	resistance	resistance	NOUN
gs-4062	646	9	testing	testing	NOUN
gs-4062	646	10	results	result	NOUN
gs-4062	646	11	,	,	PUNCT
gs-4062	646	12	comorbid	comorbid	NOUN
gs-4062	646	13	conditions	condition	NOUN
gs-4062	646	14	(	(	PUNCT
gs-4062	646	15	e.g.	e.g.	ADV
gs-4062	646	16	,	,	PUNCT
gs-4062	646	17	psychiatric	psychiatric	ADJ
gs-4062	646	18	illness	illness	NOUN
gs-4062	646	19	,	,	PUNCT
gs-4062	646	20	cardiovascular	cardiovascular	ADJ
gs-4062	646	21	or	or	CCONJ
gs-4062	646	22	bone	bone	NOUN
gs-4062	646	23	disease	disease	NOUN
gs-4062	646	24	,	,	PUNCT
gs-4062	646	25	renal	renal	ADJ
gs-4062	646	26	impairment	impairment	NOUN
gs-4062	646	27	)	)	PUNCT
gs-4062	646	28	,	,	PUNCT
gs-4062	646	29	childbearing	childbeare	VERB
gs-4062	646	30	potential	potential	NOUN
gs-4062	646	31	,	,	PUNCT
gs-4062	646	32	potential	potential	NOUN
gs-4062	646	33	for	for	ADP
gs-4062	646	34	drug	drug	NOUN
gs-4062	646	35	interactions	interaction	NOUN
gs-4062	646	36	,	,	PUNCT
gs-4062	646	37	and	and	CCONJ
gs-4062	646	38	patient	patient	ADJ
gs-4062	646	39	preference	preference	NOUN
gs-4062	646	40	regarding	regard	VERB
gs-4062	646	41	pill	pill	NOUN
gs-4062	646	42	burden	burden	NOUN
gs-4062	646	43	and	and	CCONJ
gs-4062	646	44	dosing	dose	VERB
gs-4062	646	45	frequency	frequency	NOUN
gs-4062	646	46	.	.	PUNCT
gs-4062	647	1	for	for	ADP
gs-4062	647	2	a	a	DET
gs-4062	647	3	woman	woman	NOUN
gs-4062	647	4	of	of	ADP
gs-4062	647	5	childbearing	childbearing	NOUN
gs-4062	647	6	potential	potential	NOUN
gs-4062	647	7	,	,	PUNCT
gs-4062	647	8	the	the	DET
gs-4062	647	9	discussion	discussion	NOUN
gs-4062	647	10	includes	include	VERB
gs-4062	647	11	a	a	DET
gs-4062	647	12	review	review	NOUN
gs-4062	647	13	of	of	ADP
gs-4062	647	14	the	the	DET
gs-4062	647	15	teratogenic	teratogenic	ADJ
gs-4062	647	16	potential	potential	NOUN
gs-4062	647	17	of	of	ADP
gs-4062	647	18	certain	certain	ADJ
gs-4062	647	19	drugs	drug	NOUN
gs-4062	647	20	,	,	PUNCT
gs-4062	647	21	such	such	ADJ
gs-4062	647	22	as	as	ADP
gs-4062	647	23	the	the	DET
gs-4062	647	24	previously	previously	ADV
gs-4062	647	25	noted	note	VERB
gs-4062	647	26	concerns	concern	NOUN
gs-4062	647	27	with	with	ADP
gs-4062	647	28	dolutegravir	dolutegravir	NOUN
gs-4062	647	29	,	,	PUNCT
gs-4062	647	30	though	though	SCONJ
gs-4062	647	31	subsequent	subsequent	ADJ
gs-4062	647	32	data	datum	NOUN
gs-4062	647	33	has	have	AUX
gs-4062	647	34	largely	largely	ADV
gs-4062	647	35	reassured	reassure	VERB
gs-4062	647	36	the	the	DET
gs-4062	647	37	community	community	NOUN
gs-4062	647	38	.	.	PUNCT
gs-4062	648	1	for	for	ADP
gs-4062	648	2	treatment	treatment	NOUN
gs-4062	648	3	-	-	PUNCT
gs-4062	648	4	experienced	experience	VERB
gs-4062	648	5	patients	patient	NOUN
gs-4062	648	6	with	with	ADP
gs-4062	648	7	virologic	virologic	ADJ
gs-4062	648	8	failure	failure	NOUN
gs-4062	648	9	,	,	PUNCT
gs-4062	648	10	the	the	DET
gs-4062	648	11	approach	approach	NOUN
gs-4062	648	12	is	be	AUX
gs-4062	648	13	more	more	ADV
gs-4062	648	14	complex	complex	ADJ
gs-4062	648	15	.	.	PUNCT
gs-4062	649	1	genotypic	genotypic	NOUN
gs-4062	649	2	resistance	resistance	NOUN
gs-4062	649	3	testing	testing	NOUN
gs-4062	649	4	is	be	AUX
gs-4062	649	5	essential	essential	ADJ
gs-4062	649	6	to	to	PART
gs-4062	649	7	identify	identify	VERB
gs-4062	649	8	accumulated	accumulate	VERB
gs-4062	649	9	mutations	mutation	NOUN
gs-4062	649	10	and	and	CCONJ
gs-4062	649	11	to	to	PART
gs-4062	649	12	guide	guide	VERB
gs-4062	649	13	the	the	DET
gs-4062	649	14	selection	selection	NOUN
gs-4062	649	15	of	of	ADP
gs-4062	649	16	a	a	DET
gs-4062	649	17	new	new	ADJ
gs-4062	649	18	regimen	regiman	NOUN
gs-4062	649	19	that	that	PRON
gs-4062	649	20	includes	include	VERB
gs-4062	649	21	at	at	ADV
gs-4062	649	22	least	least	ADV
gs-4062	649	23	two	two	NUM
gs-4062	649	24	,	,	PUNCT
gs-4062	649	25	and	and	CCONJ
gs-4062	649	26	preferably	preferably	ADV
gs-4062	649	27	three	three	NUM
gs-4062	649	28	,	,	PUNCT
gs-4062	649	29	fully	fully	ADV
gs-4062	649	30	active	active	ADJ
gs-4062	649	31	drugs	drug	NOUN
gs-4062	649	32	.	.	PUNCT
gs-4062	650	1	this	this	PRON
gs-4062	650	2	often	often	ADV
gs-4062	650	3	involves	involve	VERB
gs-4062	650	4	utilizing	utilize	VERB
gs-4062	650	5	newer	new	ADJ
gs-4062	650	6	agents	agent	NOUN
gs-4062	650	7	from	from	ADP
gs-4062	650	8	existing	exist	VERB
gs-4062	650	9	classes	class	NOUN
gs-4062	650	10	with	with	ADP
gs-4062	650	11	higher	high	ADJ
gs-4062	650	12	resistance	resistance	NOUN
gs-4062	650	13	barriers	barrier	NOUN
gs-4062	650	14	,	,	PUNCT
gs-4062	650	15	such	such	ADJ
gs-4062	650	16	as	as	ADP
gs-4062	650	17	darunavir	darunavir	PROPN
gs-4062	650	18	or	or	CCONJ
gs-4062	650	19	dolutegravir	dolutegravir	NOUN
gs-4062	650	20	,	,	PUNCT
gs-4062	650	21	or	or	CCONJ
gs-4062	650	22	incorporating	incorporate	VERB
gs-4062	650	23	agents	agent	NOUN
gs-4062	650	24	from	from	ADP
gs-4062	650	25	newer	new	ADJ
gs-4062	650	26	classes	class	NOUN
gs-4062	650	27	like	like	ADP
gs-4062	650	28	attachment	attachment	NOUN
gs-4062	650	29	inhibitors	inhibitor	NOUN
gs-4062	650	30	or	or	CCONJ
gs-4062	650	31	long	long	ADV
gs-4062	650	32	-	-	PUNCT
gs-4062	650	33	acting	act	VERB
gs-4062	650	34	therapies	therapy	NOUN
gs-4062	650	35	.	.	PUNCT
gs-4062	651	1	the	the	DET
gs-4062	651	2	ultimate	ultimate	ADJ
gs-4062	651	3	goal	goal	NOUN
gs-4062	651	4	of	of	ADP
gs-4062	651	5	clinical	clinical	ADJ
gs-4062	651	6	management	management	NOUN
gs-4062	651	7	is	be	AUX
gs-4062	651	8	to	to	PART
gs-4062	651	9	achieve	achieve	VERB
gs-4062	651	10	and	and	CCONJ
gs-4062	651	11	maintain	maintain	VERB
gs-4062	651	12	durably	durably	ADV
gs-4062	651	13	undetectable	undetectable	ADJ
gs-4062	651	14	levels	level	NOUN
gs-4062	651	15	of	of	ADP
gs-4062	651	16	hiv	hiv	PROPN
gs-4062	651	17	rna	rna	PROPN
gs-4062	651	18	in	in	ADP
gs-4062	651	19	the	the	DET
gs-4062	651	20	plasma	plasma	NOUN
gs-4062	651	21	,	,	PUNCT
gs-4062	651	22	which	which	PRON
gs-4062	651	23	is	be	AUX
gs-4062	651	24	synonymous	synonymous	ADJ
gs-4062	651	25	with	with	ADP
gs-4062	651	26	preserving	preserve	VERB
gs-4062	651	27	health	health	NOUN
gs-4062	651	28	and	and	CCONJ
gs-4062	651	29	preventing	prevent	VERB
gs-4062	651	30	transmission	transmission	NOUN
gs-4062	651	31	.	.	PUNCT
gs-4062	652	1	this	this	DET
gs-4062	652	2	state	state	NOUN
gs-4062	652	3	,	,	PUNCT
gs-4062	652	4	undetectable	undetectable	ADJ
gs-4062	652	5	=	=	SYM
gs-4062	652	6	untransmittable	untransmittable	ADJ
gs-4062	652	7	,	,	PUNCT
gs-4062	652	8	is	be	AUX
gs-4062	652	9	a	a	DET
gs-4062	652	10	powerful	powerful	ADJ
gs-4062	652	11	public	public	ADJ
gs-4062	652	12	health	health	NOUN
gs-4062	652	13	message	message	NOUN
gs-4062	652	14	and	and	CCONJ
gs-4062	652	15	a	a	DET
gs-4062	652	16	testament	testament	NOUN
gs-4062	652	17	to	to	ADP
gs-4062	652	18	the	the	DET
gs-4062	652	19	effectiveness	effectiveness	NOUN
gs-4062	652	20	of	of	ADP
gs-4062	652	21	modern	modern	ADJ
gs-4062	652	22	antiretroviral	antiretroviral	ADJ
gs-4062	652	23	therapy	therapy	NOUN
gs-4062	652	24	.	.	PUNCT
gs-4062	653	1	effects	effect	NOUN
gs-4062	653	2	and	and	CCONJ
gs-4062	653	3	benefits	benefit	NOUN
gs-4062	653	4	:	:	PUNCT
gs-4062	653	5	virologic	virologic	ADJ
gs-4062	653	6	suppression	suppression	NOUN
gs-4062	653	7	and	and	CCONJ
gs-4062	653	8	beyond	beyond	ADP
gs-4062	653	9	the	the	DET
gs-4062	653	10	primary	primary	ADJ
gs-4062	653	11	and	and	CCONJ
gs-4062	653	12	most	most	ADV
gs-4062	653	13	direct	direct	ADJ
gs-4062	653	14	effect	effect	NOUN
gs-4062	653	15	of	of	ADP
gs-4062	653	16	effective	effective	ADJ
gs-4062	653	17	antiretroviral	antiretroviral	ADJ
gs-4062	653	18	therapy	therapy	NOUN
gs-4062	653	19	is	be	AUX
gs-4062	653	20	the	the	DET
gs-4062	653	21	suppression	suppression	NOUN
gs-4062	653	22	of	of	ADP
gs-4062	653	23	viral	viral	ADJ
gs-4062	653	24	replication	replication	NOUN
gs-4062	653	25	,	,	PUNCT
gs-4062	653	26	measured	measure	VERB
gs-4062	653	27	as	as	ADP
gs-4062	653	28	a	a	DET
gs-4062	653	29	reduction	reduction	NOUN
gs-4062	653	30	in	in	ADP
gs-4062	653	31	plasma	plasma	NOUN
gs-4062	653	32	hiv	hiv	PROPN
gs-4062	653	33	rna	rna	PROPN
gs-4062	653	34	to	to	ADP
gs-4062	653	35	undetectable	undetectable	ADJ
gs-4062	653	36	levels	level	NOUN
gs-4062	653	37	by	by	ADP
gs-4062	653	38	standard	standard	ADJ
gs-4062	653	39	assays	assay	NOUN
gs-4062	653	40	.	.	PUNCT
gs-4062	654	1	this	this	DET
gs-4062	654	2	virologic	virologic	ADJ
gs-4062	654	3	control	control	NOUN
gs-4062	654	4	is	be	AUX
gs-4062	654	5	the	the	DET
gs-4062	654	6	prerequisite	prerequisite	NOUN
gs-4062	654	7	for	for	ADP
gs-4062	654	8	all	all	DET
gs-4062	654	9	subsequent	subsequent	ADJ
gs-4062	654	10	benefits	benefit	NOUN
gs-4062	654	11	.	.	PUNCT
gs-4062	655	1	with	with	SCONJ
gs-4062	655	2	replication	replication	NOUN
gs-4062	655	3	halted	halt	VERB
gs-4062	655	4	,	,	PUNCT
gs-4062	655	5	the	the	DET
gs-4062	655	6	relentless	relentless	ADJ
gs-4062	655	7	destruction	destruction	NOUN
gs-4062	655	8	of	of	ADP
gs-4062	655	9	cd4	cd4	PROPN
gs-4062	655	10	t	t	PROPN
gs-4062	655	11	-	-	PUNCT
gs-4062	655	12	lymphocytes	lymphocyte	NOUN
gs-4062	655	13	is	be	AUX
gs-4062	655	14	stopped	stop	VERB
gs-4062	655	15	.	.	PUNCT
gs-4062	656	1	this	this	PRON
gs-4062	656	2	allows	allow	VERB
gs-4062	656	3	for	for	ADP
gs-4062	656	4	the	the	DET
gs-4062	656	5	gradual	gradual	ADJ
gs-4062	656	6	and	and	CCONJ
gs-4062	656	7	often	often	ADV
gs-4062	656	8	substantial	substantial	ADJ
gs-4062	656	9	recovery	recovery	NOUN
gs-4062	656	10	of	of	ADP
gs-4062	656	11	the	the	DET
gs-4062	656	12	immune	immune	ADJ
gs-4062	656	13	system	system	NOUN
gs-4062	656	14	,	,	PUNCT
gs-4062	656	15	reflected	reflect	VERB
gs-4062	656	16	in	in	ADP
gs-4062	656	17	a	a	DET
gs-4062	656	18	rising	rise	VERB
gs-4062	656	19	cd4	cd4	PROPN
gs-4062	656	20	cell	cell	NOUN
gs-4062	656	21	count	count	NOUN
gs-4062	656	22	.	.	PUNCT
gs-4062	657	1	this	this	DET
gs-4062	657	2	immune	immune	ADJ
gs-4062	657	3	reconstitution	reconstitution	NOUN
gs-4062	657	4	reverses	reverse	VERB
gs-4062	657	5	the	the	DET
gs-4062	657	6	immunodeficiency	immunodeficiency	NOUN
gs-4062	657	7	caused	cause	VERB
gs-4062	657	8	by	by	ADP
gs-4062	657	9	hiv	hiv	PROPN
gs-4062	657	10	,	,	PUNCT
gs-4062	657	11	dramatically	dramatically	ADV
gs-4062	657	12	reducing	reduce	VERB
gs-4062	657	13	the	the	DET
gs-4062	657	14	incidence	incidence	NOUN
gs-4062	657	15	georgian	georgian	NOUN
gs-4062	657	16	scientists/	scientists/	NUM
gs-4062	657	17	.	.	PUNCT
gs-4062	658	1	7	7	NUM
gs-4062	658	2	n	n	PRON
gs-4062	658	3	3	3	NUM
gs-4062	658	4	,	,	PUNCT
gs-4062	658	5	2025	2025	NUM
gs-4062	658	6	550	550	NUM
gs-4062	658	7	of	of	ADP
gs-4062	658	8	opportunistic	opportunistic	ADJ
gs-4062	658	9	infections	infection	NOUN
gs-4062	658	10	and	and	CCONJ
gs-4062	658	11	aids	aid	NOUN
gs-4062	658	12	-	-	PUNCT
gs-4062	658	13	defining	define	VERB
gs-4062	658	14	malignancies	malignancy	NOUN
gs-4062	658	15	,	,	PUNCT
gs-4062	658	16	the	the	DET
gs-4062	658	17	historical	historical	ADJ
gs-4062	658	18	scourges	scourge	NOUN
gs-4062	658	19	of	of	ADP
gs-4062	658	20	the	the	DET
gs-4062	658	21	aids	aid	NOUN
gs-4062	658	22	pandemic	pandemic	ADJ
gs-4062	658	23	.	.	PUNCT
gs-4062	659	1	the	the	DET
gs-4062	659	2	benefits	benefit	NOUN
gs-4062	659	3	extend	extend	VERB
gs-4062	659	4	far	far	ADV
gs-4062	659	5	beyond	beyond	ADP
gs-4062	659	6	the	the	DET
gs-4062	659	7	prevention	prevention	NOUN
gs-4062	659	8	of	of	ADP
gs-4062	659	9	aids	aids	PROPN
gs-4062	659	10	-	-	PUNCT
gs-4062	659	11	related	relate	VERB
gs-4062	659	12	events	event	NOUN
gs-4062	659	13	.	.	PUNCT
gs-4062	660	1	effective	effective	ADJ
gs-4062	660	2	treatment	treatment	NOUN
gs-4062	660	3	reduces	reduce	VERB
gs-4062	660	4	chronic	chronic	ADJ
gs-4062	660	5	immune	immune	ADJ
gs-4062	660	6	activation	activation	NOUN
gs-4062	660	7	and	and	CCONJ
gs-4062	660	8	inflammation	inflammation	NOUN
gs-4062	660	9	,	,	PUNCT
gs-4062	660	10	which	which	PRON
gs-4062	660	11	are	be	AUX
gs-4062	660	12	now	now	ADV
gs-4062	660	13	understood	understand	VERB
gs-4062	660	14	to	to	PART
gs-4062	660	15	be	be	AUX
gs-4062	660	16	key	key	ADJ
gs-4062	660	17	drivers	driver	NOUN
gs-4062	660	18	of	of	ADP
gs-4062	660	19	non	non	ADJ
gs-4062	660	20	-	-	ADJ
gs-4062	660	21	aids	aids	ADJ
gs-4062	660	22	co	co	NOUN
gs-4062	660	23	-	-	NOUN
gs-4062	660	24	morbidities	morbidity	NOUN
gs-4062	660	25	.	.	PUNCT
gs-4062	661	1	these	these	PRON
gs-4062	661	2	include	include	VERB
gs-4062	661	3	cardiovascular	cardiovascular	ADJ
gs-4062	661	4	disease	disease	NOUN
gs-4062	661	5	,	,	PUNCT
gs-4062	661	6	neurocognitive	neurocognitive	ADJ
gs-4062	661	7	decline	decline	NOUN
gs-4062	661	8	,	,	PUNCT
gs-4062	661	9	liver	liver	NOUN
gs-4062	661	10	and	and	CCONJ
gs-4062	661	11	kidney	kidney	NOUN
gs-4062	661	12	disease	disease	NOUN
gs-4062	661	13	,	,	PUNCT
gs-4062	661	14	and	and	CCONJ
gs-4062	661	15	osteoporosis	osteoporosis	NOUN
gs-4062	661	16	.	.	PUNCT
gs-4062	662	1	by	by	ADP
gs-4062	662	2	mitigating	mitigate	VERB
gs-4062	662	3	this	this	DET
gs-4062	662	4	inflammatory	inflammatory	ADJ
gs-4062	662	5	state	state	NOUN
gs-4062	662	6	,	,	PUNCT
gs-4062	662	7	antiretroviral	antiretroviral	ADJ
gs-4062	662	8	therapy	therapy	NOUN
gs-4062	662	9	lowers	lower	VERB
gs-4062	662	10	the	the	DET
gs-4062	662	11	risk	risk	NOUN
gs-4062	662	12	of	of	ADP
gs-4062	662	13	myocardial	myocardial	ADJ
gs-4062	662	14	infarction	infarction	NOUN
gs-4062	662	15	,	,	PUNCT
gs-4062	662	16	stroke	stroke	NOUN
gs-4062	662	17	,	,	PUNCT
gs-4062	662	18	and	and	CCONJ
gs-4062	662	19	other	other	ADJ
gs-4062	662	20	end	end	ADJ
gs-4062	662	21	-	-	PUNCT
gs-4062	662	22	organ	organ	NOUN
gs-4062	662	23	damage	damage	NOUN
gs-4062	662	24	,	,	PUNCT
gs-4062	662	25	effectively	effectively	ADV
gs-4062	662	26	normalizing	normalize	VERB
gs-4062	662	27	the	the	DET
gs-4062	662	28	life	life	NOUN
gs-4062	662	29	expectancy	expectancy	NOUN
gs-4062	662	30	of	of	ADP
gs-4062	662	31	people	people	NOUN
gs-4062	662	32	living	live	VERB
gs-4062	662	33	with	with	ADP
gs-4062	662	34	hiv	hiv	PROPN
gs-4062	662	35	who	who	PRON
gs-4062	662	36	have	have	VERB
gs-4062	662	37	access	access	NOUN
gs-4062	662	38	to	to	ADP
gs-4062	662	39	and	and	CCONJ
gs-4062	662	40	are	be	AUX
gs-4062	662	41	retained	retain	VERB
gs-4062	662	42	in	in	ADP
gs-4062	662	43	care	care	NOUN
gs-4062	662	44	.	.	PUNCT
gs-4062	663	1	furthermore	furthermore	ADV
gs-4062	663	2	,	,	PUNCT
gs-4062	663	3	achieving	achieve	VERB
gs-4062	663	4	an	an	DET
gs-4062	663	5	undetectable	undetectable	ADJ
gs-4062	663	6	viral	viral	ADJ
gs-4062	663	7	load	load	NOUN
gs-4062	663	8	has	have	VERB
gs-4062	663	9	a	a	DET
gs-4062	663	10	profound	profound	ADJ
gs-4062	663	11	impact	impact	NOUN
gs-4062	663	12	on	on	ADP
gs-4062	663	13	sexual	sexual	ADJ
gs-4062	663	14	and	and	CCONJ
gs-4062	663	15	reproductive	reproductive	ADJ
gs-4062	663	16	health	health	NOUN
gs-4062	663	17	.	.	PUNCT
gs-4062	664	1	the	the	DET
gs-4062	664	2	u	u	PROPN
gs-4062	664	3	=	=	PROPN
gs-4062	664	4	u	u	ADJ
gs-4062	664	5	consensus	consensus	NOUN
gs-4062	664	6	,	,	PUNCT
gs-4062	664	7	based	base	VERB
gs-4062	664	8	on	on	ADP
gs-4062	664	9	robust	robust	ADJ
gs-4062	664	10	scientific	scientific	ADJ
gs-4062	664	11	evidence	evidence	NOUN
gs-4062	664	12	from	from	ADP
gs-4062	664	13	large	large	ADJ
gs-4062	664	14	studies	study	NOUN
gs-4062	664	15	such	such	ADJ
gs-4062	664	16	as	as	ADP
gs-4062	664	17	partner	partner	NOUN
gs-4062	664	18	and	and	CCONJ
gs-4062	664	19	hptn	hptn	PROPN
gs-4062	664	20	052	052	NUM
gs-4062	664	21	,	,	PUNCT
gs-4062	664	22	confirms	confirm	VERB
gs-4062	664	23	that	that	SCONJ
gs-4062	664	24	individuals	individual	NOUN
gs-4062	664	25	with	with	ADP
gs-4062	664	26	an	an	DET
gs-4062	664	27	undetectable	undetectable	ADJ
gs-4062	664	28	viral	viral	ADJ
gs-4062	664	29	load	load	NOUN
gs-4062	664	30	can	can	AUX
gs-4062	664	31	not	not	PART
gs-4062	664	32	sexually	sexually	ADV
gs-4062	664	33	transmit	transmit	VERB
gs-4062	664	34	hiv	hiv	PROPN
gs-4062	664	35	to	to	ADP
gs-4062	664	36	their	their	PRON
gs-4062	664	37	partners	partner	NOUN
gs-4062	664	38	.	.	PUNCT
gs-4062	665	1	this	this	DET
gs-4062	665	2	knowledge	knowledge	NOUN
gs-4062	665	3	is	be	AUX
gs-4062	665	4	empowering	empowering	ADJ
gs-4062	665	5	,	,	PUNCT
gs-4062	665	6	significantly	significantly	ADV
gs-4062	665	7	reducing	reduce	VERB
gs-4062	665	8	the	the	DET
gs-4062	665	9	internalized	internalized	ADJ
gs-4062	665	10	stigma	stigma	NOUN
gs-4062	665	11	and	and	CCONJ
gs-4062	665	12	anxiety	anxiety	NOUN
gs-4062	665	13	associated	associate	VERB
gs-4062	665	14	with	with	ADP
gs-4062	665	15	hiv	hiv	PROPN
gs-4062	665	16	transmission	transmission	NOUN
gs-4062	665	17	risk	risk	NOUN
gs-4062	665	18	and	and	CCONJ
gs-4062	665	19	enabling	enable	VERB
gs-4062	665	20	people	people	NOUN
gs-4062	665	21	to	to	PART
gs-4062	665	22	live	live	VERB
gs-4062	665	23	full	full	ADJ
gs-4062	665	24	sexual	sexual	ADJ
gs-4062	665	25	and	and	CCONJ
gs-4062	665	26	romantic	romantic	ADJ
gs-4062	665	27	lives	life	NOUN
gs-4062	665	28	without	without	ADP
gs-4062	665	29	fear	fear	NOUN
gs-4062	665	30	.	.	PUNCT
gs-4062	666	1	toxicities	toxicity	NOUN
gs-4062	666	2	and	and	CCONJ
gs-4062	666	3	adverse	adverse	ADJ
gs-4062	666	4	effects	effect	NOUN
gs-4062	666	5	:	:	PUNCT
gs-4062	666	6	from	from	ADP
gs-4062	666	7	acute	acute	NOUN
gs-4062	666	8	to	to	ADP
gs-4062	666	9	chronic	chronic	NOUN
gs-4062	666	10	despite	despite	SCONJ
gs-4062	666	11	their	their	PRON
gs-4062	666	12	overall	overall	ADJ
gs-4062	666	13	excellent	excellent	ADJ
gs-4062	666	14	safety	safety	NOUN
gs-4062	666	15	profile	profile	NOUN
gs-4062	666	16	,	,	PUNCT
gs-4062	666	17	antiretroviral	antiretroviral	ADJ
gs-4062	666	18	drugs	drug	NOUN
gs-4062	666	19	are	be	AUX
gs-4062	666	20	associated	associate	VERB
gs-4062	666	21	with	with	ADP
gs-4062	666	22	a	a	DET
gs-4062	666	23	range	range	NOUN
gs-4062	666	24	of	of	ADP
gs-4062	666	25	potential	potential	ADJ
gs-4062	666	26	toxicities	toxicity	NOUN
gs-4062	666	27	,	,	PUNCT
gs-4062	666	28	which	which	PRON
gs-4062	666	29	can	can	AUX
gs-4062	666	30	be	be	AUX
gs-4062	666	31	broadly	broadly	ADV
gs-4062	666	32	categorized	categorize	VERB
gs-4062	666	33	as	as	ADP
gs-4062	666	34	acute	acute	NOUN
gs-4062	666	35	,	,	PUNCT
gs-4062	666	36	class	class	NOUN
gs-4062	666	37	-	-	PUNCT
gs-4062	666	38	specific	specific	ADJ
gs-4062	666	39	,	,	PUNCT
gs-4062	666	40	and	and	CCONJ
gs-4062	666	41	long	long	ADJ
gs-4062	666	42	-	-	PUNCT
gs-4062	666	43	term	term	NOUN
gs-4062	666	44	.	.	PUNCT
gs-4062	667	1	acute	acute	ADJ
gs-4062	667	2	side	side	NOUN
gs-4062	667	3	effects	effect	NOUN
gs-4062	667	4	often	often	ADV
gs-4062	667	5	occur	occur	VERB
gs-4062	667	6	during	during	ADP
gs-4062	667	7	the	the	DET
gs-4062	667	8	initial	initial	ADJ
gs-4062	667	9	weeks	week	NOUN
gs-4062	667	10	of	of	ADP
gs-4062	667	11	therapy	therapy	NOUN
gs-4062	667	12	and	and	CCONJ
gs-4062	667	13	typically	typically	ADV
gs-4062	667	14	subside	subside	ADV
gs-4062	667	15	.	.	PUNCT
gs-4062	668	1	these	these	PRON
gs-4062	668	2	include	include	VERB
gs-4062	668	3	gastrointestinal	gastrointestinal	ADJ
gs-4062	668	4	disturbances	disturbance	NOUN
gs-4062	668	5	such	such	ADJ
gs-4062	668	6	as	as	ADP
gs-4062	668	7	nausea	nausea	NOUN
gs-4062	668	8	,	,	PUNCT
gs-4062	668	9	diarrhea	diarrhea	NOUN
gs-4062	668	10	,	,	PUNCT
gs-4062	668	11	and	and	CCONJ
gs-4062	668	12	abdominal	abdominal	ADJ
gs-4062	668	13	pain	pain	NOUN
gs-4062	668	14	,	,	PUNCT
gs-4062	668	15	as	as	ADV
gs-4062	668	16	well	well	ADV
gs-4062	668	17	as	as	ADP
gs-4062	668	18	neurological	neurological	ADJ
gs-4062	668	19	symptoms	symptom	NOUN
gs-4062	668	20	like	like	ADP
gs-4062	668	21	dizziness	dizziness	NOUN
gs-4062	668	22	,	,	PUNCT
gs-4062	668	23	vivid	vivid	ADJ
gs-4062	668	24	dreams	dream	NOUN
gs-4062	668	25	,	,	PUNCT
gs-4062	668	26	and	and	CCONJ
gs-4062	668	27	insomnia	insomnia	NOUN
gs-4062	668	28	,	,	PUNCT
gs-4062	668	29	particularly	particularly	ADV
gs-4062	668	30	associated	associate	VERB
gs-4062	668	31	with	with	ADP
gs-4062	668	32	older	old	ADJ
gs-4062	668	33	non	non	ADJ
gs-4062	668	34	-	-	ADJ
gs-4062	668	35	nucleoside	nucleoside	ADJ
gs-4062	668	36	reverse	reverse	ADJ
gs-4062	668	37	transcriptase	transcriptase	NOUN
gs-4062	668	38	inhibitors	inhibitor	NOUN
gs-4062	668	39	like	like	ADP
gs-4062	668	40	efavirenz	efavirenz	NOUN
gs-4062	668	41	.	.	PUNCT
gs-4062	669	1	while	while	SCONJ
gs-4062	669	2	often	often	ADV
gs-4062	669	3	self	self	NOUN
gs-4062	669	4	-	-	PUNCT
gs-4062	669	5	limiting	limit	VERB
gs-4062	669	6	,	,	PUNCT
gs-4062	669	7	these	these	DET
gs-4062	669	8	symptoms	symptom	NOUN
gs-4062	669	9	can	can	AUX
gs-4062	669	10	impact	impact	VERB
gs-4062	669	11	adherence	adherence	NOUN
gs-4062	669	12	and	and	CCONJ
gs-4062	669	13	quality	quality	NOUN
gs-4062	669	14	of	of	ADP
gs-4062	669	15	life	life	NOUN
gs-4062	669	16	,	,	PUNCT
gs-4062	669	17	necessitating	necessitate	VERB
gs-4062	669	18	supportive	supportive	ADJ
gs-4062	669	19	care	care	NOUN
gs-4062	669	20	and	and	CCONJ
gs-4062	669	21	,	,	PUNCT
gs-4062	669	22	in	in	ADP
gs-4062	669	23	some	some	DET
gs-4062	669	24	cases	case	NOUN
gs-4062	669	25	,	,	PUNCT
gs-4062	669	26	a	a	DET
gs-4062	669	27	switch	switch	NOUN
gs-4062	669	28	to	to	ADP
gs-4062	669	29	a	a	DET
gs-4062	669	30	better	well	ADV
gs-4062	669	31	-	-	PUNCT
gs-4062	669	32	tolerated	tolerate	VERB
gs-4062	669	33	regimen	regiman	NOUN
gs-4062	669	34	.	.	PUNCT
gs-4062	670	1	class	class	NOUN
gs-4062	670	2	-	-	PUNCT
gs-4062	670	3	specific	specific	ADJ
gs-4062	670	4	toxicities	toxicity	NOUN
gs-4062	670	5	are	be	AUX
gs-4062	670	6	linked	link	VERB
gs-4062	670	7	to	to	ADP
gs-4062	670	8	the	the	DET
gs-4062	670	9	pharmacological	pharmacological	ADJ
gs-4062	670	10	mechanism	mechanism	NOUN
gs-4062	670	11	of	of	ADP
gs-4062	670	12	the	the	DET
gs-4062	670	13	drug	drug	NOUN
gs-4062	670	14	class	class	NOUN
gs-4062	670	15	.	.	PUNCT
gs-4062	671	1	nucleoside	nucleoside	ADV
gs-4062	671	2	reverse	reverse	ADJ
gs-4062	671	3	transcriptase	transcriptase	NOUN
gs-4062	671	4	inhibitors	inhibitor	NOUN
gs-4062	671	5	have	have	AUX
gs-4062	671	6	been	be	AUX
gs-4062	671	7	historically	historically	ADV
gs-4062	671	8	associated	associate	VERB
gs-4062	671	9	with	with	ADP
gs-4062	671	10	mitochondrial	mitochondrial	ADJ
gs-4062	671	11	toxicity	toxicity	NOUN
gs-4062	671	12	,	,	PUNCT
gs-4062	671	13	as	as	SCONJ
gs-4062	671	14	they	they	PRON
gs-4062	671	15	can	can	AUX
gs-4062	671	16	inhibit	inhibit	VERB
gs-4062	671	17	the	the	DET
gs-4062	671	18	human	human	ADJ
gs-4062	671	19	mitochondrial	mitochondrial	ADJ
gs-4062	671	20	dna	dna	PROPN
gs-4062	671	21	polymerase	polymerase	NOUN
gs-4062	671	22	gamma	gamma	NOUN
gs-4062	671	23	.	.	PUNCT
gs-4062	672	1	this	this	PRON
gs-4062	672	2	can	can	AUX
gs-4062	672	3	manifest	manifest	VERB
gs-4062	672	4	as	as	ADP
gs-4062	672	5	peripheral	peripheral	ADJ
gs-4062	672	6	neuropathy	neuropathy	ADJ
gs-4062	672	7	,	,	PUNCT
gs-4062	672	8	pancreatitis	pancreatitis	PROPN
gs-4062	672	9	,	,	PUNCT
gs-4062	672	10	lipoatrophy	lipoatrophy	NOUN
gs-4062	672	11	(	(	PUNCT
gs-4062	672	12	the	the	DET
gs-4062	672	13	loss	loss	NOUN
gs-4062	672	14	of	of	ADP
gs-4062	672	15	subcutaneous	subcutaneous	ADJ
gs-4062	672	16	fat	fat	NOUN
gs-4062	672	17	)	)	PUNCT
gs-4062	672	18	,	,	PUNCT
gs-4062	672	19	and	and	CCONJ
gs-4062	672	20	lactic	lactic	ADJ
gs-4062	672	21	acidosis	acidosis	NOUN
gs-4062	672	22	.	.	PUNCT
gs-4062	673	1	while	while	SCONJ
gs-4062	673	2	newer	new	ADJ
gs-4062	673	3	nrtis	nrtis	PROPN
gs-4062	673	4	like	like	ADP
gs-4062	673	5	tenofovir	tenofovir	PROPN
gs-4062	673	6	alafenamide	alafenamide	PROPN
gs-4062	673	7	and	and	CCONJ
gs-4062	673	8	abacavir	abacavir	NOUN
gs-4062	673	9	have	have	VERB
gs-4062	673	10	a	a	DET
gs-4062	673	11	much	much	ADV
gs-4062	673	12	improved	improved	ADJ
gs-4062	673	13	mitochondrial	mitochondrial	ADJ
gs-4062	673	14	toxicity	toxicity	NOUN
gs-4062	673	15	profile	profile	NOUN
gs-4062	673	16	,	,	PUNCT
gs-4062	673	17	awareness	awareness	NOUN
gs-4062	673	18	of	of	ADP
gs-4062	673	19	this	this	DET
gs-4062	673	20	history	history	NOUN
gs-4062	673	21	remains	remain	VERB
gs-4062	673	22	important	important	ADJ
gs-4062	673	23	.	.	PUNCT
gs-4062	674	1	protease	protease	NOUN
gs-4062	674	2	inhibitors	inhibitor	NOUN
gs-4062	674	3	are	be	AUX
gs-4062	674	4	frequently	frequently	ADV
gs-4062	674	5	associated	associate	VERB
gs-4062	674	6	with	with	ADP
gs-4062	674	7	metabolic	metabolic	NOUN
gs-4062	674	8	complications	complication	NOUN
gs-4062	674	9	,	,	PUNCT
gs-4062	674	10	including	include	VERB
gs-4062	674	11	dyslipidemia	dyslipidemia	NOUN
gs-4062	674	12	(	(	PUNCT
gs-4062	674	13	elevated	elevated	ADJ
gs-4062	674	14	triglycerides	triglyceride	NOUN
gs-4062	674	15	and	and	CCONJ
gs-4062	674	16	cholesterol	cholesterol	NOUN
gs-4062	674	17	)	)	PUNCT
gs-4062	674	18	and	and	CCONJ
gs-4062	674	19	insulin	insulin	NOUN
gs-4062	674	20	resistance	resistance	NOUN
gs-4062	674	21	,	,	PUNCT
gs-4062	674	22	which	which	PRON
gs-4062	674	23	can	can	AUX
gs-4062	674	24	increase	increase	VERB
gs-4062	674	25	long	long	ADJ
gs-4062	674	26	-	-	PUNCT
gs-4062	674	27	term	term	NOUN
gs-4062	674	28	cardiovascular	cardiovascular	ADJ
gs-4062	674	29	risk	risk	NOUN
gs-4062	674	30	.	.	PUNCT
gs-4062	675	1	some	some	PRON
gs-4062	675	2	,	,	PUNCT
gs-4062	675	3	like	like	ADP
gs-4062	675	4	atazanavir	atazanavir	PROPN
gs-4062	675	5	,	,	PUNCT
gs-4062	675	6	can	can	AUX
gs-4062	675	7	cause	cause	VERB
gs-4062	675	8	unconjugated	unconjugated	ADJ
gs-4062	675	9	hyperbilirubinemia	hyperbilirubinemia	NOUN
gs-4062	675	10	,	,	PUNCT
gs-4062	675	11	a	a	DET
gs-4062	675	12	benign	benign	ADJ
gs-4062	675	13	yellowing	yellowing	NOUN
gs-4062	675	14	of	of	ADP
gs-4062	675	15	the	the	DET
gs-4062	675	16	eyes	eye	NOUN
gs-4062	675	17	and	and	CCONJ
gs-4062	675	18	skin	skin	NOUN
gs-4062	675	19	that	that	PRON
gs-4062	675	20	is	be	AUX
gs-4062	675	21	often	often	ADV
gs-4062	675	22	confused	confuse	VERB
gs-4062	675	23	with	with	ADP
gs-4062	675	24	liver	liver	NOUN
gs-4062	675	25	disease	disease	NOUN
gs-4062	675	26	.	.	PUNCT
gs-4062	676	1	integrase	integrase	NOUN
gs-4062	676	2	inhibitors	inhibitor	NOUN
gs-4062	676	3	are	be	AUX
gs-4062	676	4	generally	generally	ADV
gs-4062	676	5	well	well	ADV
gs-4062	676	6	-	-	PUNCT
gs-4062	676	7	tolerated	tolerate	VERB
gs-4062	676	8	but	but	CCONJ
gs-4062	676	9	have	have	VERB
gs-4062	676	10	a	a	DET
gs-4062	676	11	characteristic	characteristic	ADJ
gs-4062	676	12	association	association	NOUN
gs-4062	676	13	with	with	ADP
gs-4062	676	14	weight	weight	NOUN
gs-4062	676	15	gain	gain	NOUN
gs-4062	676	16	.	.	PUNCT
gs-4062	677	1	this	this	DET
gs-4062	677	2	weight	weight	NOUN
gs-4062	677	3	gain	gain	NOUN
gs-4062	677	4	appears	appear	VERB
gs-4062	677	5	to	to	PART
gs-4062	677	6	be	be	AUX
gs-4062	677	7	more	more	ADV
gs-4062	677	8	pronounced	pronounce	VERB
gs-4062	677	9	with	with	ADP
gs-4062	677	10	dolutegravir	dolutegravir	NOUN
gs-4062	677	11	and	and	CCONJ
gs-4062	677	12	bictegravir	bictegravir	PROPN
gs-4062	677	13	than	than	ADP
gs-4062	677	14	with	with	ADP
gs-4062	677	15	other	other	ADJ
gs-4062	677	16	agents	agent	NOUN
gs-4062	677	17	and	and	CCONJ
gs-4062	677	18	can	can	AUX
gs-4062	677	19	be	be	AUX
gs-4062	677	20	a	a	DET
gs-4062	677	21	source	source	NOUN
gs-4062	677	22	of	of	ADP
gs-4062	677	23	significant	significant	ADJ
gs-4062	677	24	patient	patient	ADJ
gs-4062	677	25	concern	concern	NOUN
gs-4062	677	26	.	.	PUNCT
gs-4062	678	1	the	the	DET
gs-4062	678	2	mechanism	mechanism	NOUN
gs-4062	678	3	is	be	AUX
gs-4062	678	4	not	not	PART
gs-4062	678	5	fully	fully	ADV
gs-4062	678	6	understood	understand	VERB
gs-4062	678	7	but	but	CCONJ
gs-4062	678	8	is	be	AUX
gs-4062	678	9	an	an	DET
gs-4062	678	10	area	area	NOUN
gs-4062	678	11	of	of	ADP
gs-4062	678	12	active	active	ADJ
gs-4062	678	13	investigation	investigation	NOUN
gs-4062	678	14	.	.	PUNCT
gs-4062	679	1	there	there	PRON
gs-4062	679	2	is	be	VERB
gs-4062	679	3	also	also	ADV
gs-4062	679	4	a	a	DET
gs-4062	679	5	small	small	ADJ
gs-4062	679	6	risk	risk	NOUN
gs-4062	679	7	of	of	ADP
gs-4062	679	8	neuropsychiatric	neuropsychiatric	ADJ
gs-4062	679	9	effects	effect	NOUN
gs-4062	679	10	,	,	PUNCT
gs-4062	679	11	such	such	ADJ
gs-4062	679	12	as	as	ADP
gs-4062	679	13	insomnia	insomnia	NOUN
gs-4062	679	14	and	and	CCONJ
gs-4062	679	15	anxiety	anxiety	NOUN
gs-4062	679	16	,	,	PUNCT
gs-4062	679	17	with	with	ADP
gs-4062	679	18	some	some	DET
gs-4062	679	19	instis	instis	NOUN
gs-4062	679	20	.	.	PUNCT
gs-4062	680	1	long	long	ADJ
gs-4062	680	2	-	-	PUNCT
gs-4062	680	3	term	term	NOUN
gs-4062	680	4	toxicities	toxicity	NOUN
gs-4062	680	5	require	require	VERB
gs-4062	680	6	ongoing	ongoing	ADJ
gs-4062	680	7	monitoring	monitoring	NOUN
gs-4062	680	8	.	.	PUNCT
gs-4062	681	1	bone	bone	NOUN
gs-4062	681	2	health	health	NOUN
gs-4062	681	3	is	be	AUX
gs-4062	681	4	a	a	DET
gs-4062	681	5	concern	concern	NOUN
gs-4062	681	6	,	,	PUNCT
gs-4062	681	7	particularly	particularly	ADV
gs-4062	681	8	with	with	ADP
gs-4062	681	9	tenofovir	tenofovir	NOUN
gs-4062	681	10	disoproxil	disoproxil	VERB
gs-4062	681	11	fumarate	fumarate	NOUN
gs-4062	681	12	,	,	PUNCT
gs-4062	681	13	which	which	PRON
gs-4062	681	14	is	be	AUX
gs-4062	681	15	associated	associate	VERB
gs-4062	681	16	with	with	ADP
gs-4062	681	17	a	a	DET
gs-4062	681	18	greater	great	ADJ
gs-4062	681	19	decrease	decrease	NOUN
gs-4062	681	20	in	in	ADP
gs-4062	681	21	bone	bone	NOUN
gs-4062	681	22	mineral	mineral	NOUN
gs-4062	681	23	density	density	NOUN
gs-4062	681	24	compared	compare	VERB
gs-4062	681	25	to	to	ADP
gs-4062	681	26	its	its	PRON
gs-4062	681	27	successor	successor	NOUN
gs-4062	681	28	,	,	PUNCT
gs-4062	681	29	tenofovir	tenofovir	PROPN
gs-4062	681	30	alafenamide	alafenamide	PROPN
gs-4062	681	31	.	.	PUNCT
gs-4062	682	1	renal	renal	ADJ
gs-4062	682	2	function	function	NOUN
gs-4062	682	3	must	must	AUX
gs-4062	682	4	be	be	AUX
gs-4062	682	5	monitored	monitor	VERB
gs-4062	682	6	in	in	ADP
gs-4062	682	7	georgian	georgian	PROPN
gs-4062	682	8	scientists/	scientists/	NUM
gs-4062	682	9	.	.	PUNCT
gs-4062	683	1	7	7	NUM
gs-4062	683	2	n	n	PRON
gs-4062	683	3	3	3	NUM
gs-4062	683	4	,	,	PUNCT
gs-4062	683	5	2025	2025	NUM
gs-4062	683	6	551	551	NUM
gs-4062	683	7	patients	patient	NOUN
gs-4062	683	8	on	on	ADP
gs-4062	683	9	certain	certain	ADJ
gs-4062	683	10	drugs	drug	NOUN
gs-4062	683	11	,	,	PUNCT
gs-4062	683	12	as	as	SCONJ
gs-4062	683	13	tdf	tdf	PROPN
gs-4062	683	14	can	can	AUX
gs-4062	683	15	cause	cause	VERB
gs-4062	683	16	proximal	proximal	ADJ
gs-4062	683	17	renal	renal	ADJ
gs-4062	683	18	tubulopathy	tubulopathy	NOUN
gs-4062	683	19	and	and	CCONJ
gs-4062	683	20	decline	decline	NOUN
gs-4062	683	21	in	in	ADP
gs-4062	683	22	estimated	estimate	VERB
gs-4062	683	23	glomerular	glomerular	ADJ
gs-4062	683	24	filtration	filtration	NOUN
gs-4062	683	25	rate	rate	NOUN
gs-4062	683	26	.	.	PUNCT
gs-4062	684	1	cardiovascular	cardiovascular	ADJ
gs-4062	684	2	risk	risk	NOUN
gs-4062	684	3	assessment	assessment	NOUN
gs-4062	684	4	,	,	PUNCT
gs-4062	684	5	including	include	VERB
gs-4062	684	6	management	management	NOUN
gs-4062	684	7	of	of	ADP
gs-4062	684	8	lipid	lipid	ADJ
gs-4062	684	9	abnormalities	abnormality	NOUN
gs-4062	684	10	and	and	CCONJ
gs-4062	684	11	hypertension	hypertension	NOUN
gs-4062	684	12	,	,	PUNCT
gs-4062	684	13	is	be	AUX
gs-4062	684	14	an	an	DET
gs-4062	684	15	integral	integral	ADJ
gs-4062	684	16	part	part	NOUN
gs-4062	684	17	of	of	ADP
gs-4062	684	18	long	long	ADJ
gs-4062	684	19	-	-	PUNCT
gs-4062	684	20	term	term	NOUN
gs-4062	684	21	hiv	hiv	PROPN
gs-4062	684	22	care	care	NOUN
gs-4062	684	23	.	.	PUNCT
gs-4062	685	1	the	the	DET
gs-4062	685	2	future	future	NOUN
gs-4062	685	3	:	:	PUNCT
gs-4062	685	4	long	long	ADV
gs-4062	685	5	-	-	PUNCT
gs-4062	685	6	acting	act	VERB
gs-4062	685	7	formulations	formulation	NOUN
gs-4062	685	8	and	and	CCONJ
gs-4062	685	9	novel	novel	ADJ
gs-4062	685	10	mechanisms	mechanism	NOUN
gs-4062	685	11	the	the	DET
gs-4062	685	12	scientific	scientific	ADJ
gs-4062	685	13	discussion	discussion	NOUN
gs-4062	685	14	continues	continue	VERB
gs-4062	685	15	to	to	PART
gs-4062	685	16	push	push	VERB
gs-4062	685	17	the	the	DET
gs-4062	685	18	boundaries	boundary	NOUN
gs-4062	685	19	of	of	ADP
gs-4062	685	20	what	what	PRON
gs-4062	685	21	is	be	AUX
gs-4062	685	22	possible	possible	ADJ
gs-4062	685	23	.	.	PUNCT
gs-4062	686	1	the	the	DET
gs-4062	686	2	most	most	ADV
gs-4062	686	3	imminent	imminent	ADJ
gs-4062	686	4	future	future	NOUN
gs-4062	686	5	lies	lie	VERB
gs-4062	686	6	in	in	ADP
gs-4062	686	7	long	long	ADV
gs-4062	686	8	-	-	PUNCT
gs-4062	686	9	acting	act	VERB
gs-4062	686	10	antiretroviral	antiretroviral	ADJ
gs-4062	686	11	formulations	formulation	NOUN
gs-4062	686	12	.	.	PUNCT
gs-4062	687	1	the	the	DET
gs-4062	687	2	combination	combination	NOUN
gs-4062	687	3	of	of	ADP
gs-4062	687	4	long	long	ADV
gs-4062	687	5	-	-	PUNCT
gs-4062	687	6	acting	act	VERB
gs-4062	687	7	cabotegravir	cabotegravir	NOUN
gs-4062	687	8	and	and	CCONJ
gs-4062	687	9	rilpivirine	rilpivirine	VERB
gs-4062	687	10	,	,	PUNCT
gs-4062	687	11	administered	administer	VERB
gs-4062	687	12	via	via	ADP
gs-4062	687	13	intramuscular	intramuscular	ADJ
gs-4062	687	14	injection	injection	NOUN
gs-4062	687	15	every	every	DET
gs-4062	687	16	one	one	NUM
gs-4062	687	17	or	or	CCONJ
gs-4062	687	18	two	two	NUM
gs-4062	687	19	months	month	NOUN
gs-4062	687	20	,	,	PUNCT
gs-4062	687	21	has	have	AUX
gs-4062	687	22	proven	prove	VERB
gs-4062	687	23	non	non	ADJ
gs-4062	687	24	-	-	ADJ
gs-4062	687	25	inferior	inferior	ADJ
gs-4062	687	26	to	to	ADP
gs-4062	687	27	daily	daily	ADJ
gs-4062	687	28	oral	oral	ADJ
gs-4062	687	29	therapy	therapy	NOUN
gs-4062	687	30	.	.	PUNCT
gs-4062	688	1	this	this	DET
gs-4062	688	2	modality	modality	NOUN
gs-4062	688	3	offers	offer	VERB
gs-4062	688	4	an	an	DET
gs-4062	688	5	unparalleled	unparalleled	ADJ
gs-4062	688	6	convenience	convenience	NOUN
gs-4062	688	7	and	and	CCONJ
gs-4062	688	8	privacy	privacy	NOUN
gs-4062	688	9	,	,	PUNCT
gs-4062	688	10	freeing	free	VERB
gs-4062	688	11	individuals	individual	NOUN
gs-4062	688	12	from	from	ADP
gs-4062	688	13	the	the	DET
gs-4062	688	14	daily	daily	ADJ
gs-4062	688	15	reminder	reminder	NOUN
gs-4062	688	16	of	of	ADP
gs-4062	688	17	their	their	PRON
gs-4062	688	18	hiv	hiv	PROPN
gs-4062	688	19	status	status	NOUN
gs-4062	688	20	and	and	CCONJ
gs-4062	688	21	the	the	DET
gs-4062	688	22	potential	potential	ADJ
gs-4062	688	23	stigma	stigma	NOUN
gs-4062	688	24	of	of	ADP
gs-4062	688	25	pill	pill	NOUN
gs-4062	688	26	-	-	PUNCT
gs-4062	688	27	taking	taking	NOUN
gs-4062	688	28	.	.	PUNCT
gs-4062	689	1	it	it	PRON
gs-4062	689	2	is	be	AUX
gs-4062	689	3	a	a	DET
gs-4062	689	4	powerful	powerful	ADJ
gs-4062	689	5	tool	tool	NOUN
gs-4062	689	6	for	for	ADP
gs-4062	689	7	addressing	address	VERB
gs-4062	689	8	adherence	adherence	NOUN
gs-4062	689	9	challenges	challenge	NOUN
gs-4062	689	10	.	.	PUNCT
gs-4062	690	1	furthermore	furthermore	ADV
gs-4062	690	2	,	,	PUNCT
gs-4062	690	3	long	long	ADV
gs-4062	690	4	-	-	PUNCT
gs-4062	690	5	acting	act	VERB
gs-4062	690	6	cabotegravir	cabotegravir	NOUN
gs-4062	690	7	is	be	AUX
gs-4062	690	8	approved	approve	VERB
gs-4062	690	9	for	for	ADP
gs-4062	690	10	pre	pre	ADJ
gs-4062	690	11	-	-	ADJ
gs-4062	690	12	exposure	exposure	ADJ
gs-4062	690	13	prophylaxis	prophylaxis	NOUN
gs-4062	690	14	,	,	PUNCT
gs-4062	690	15	providing	provide	VERB
gs-4062	690	16	a	a	DET
gs-4062	690	17	highly	highly	ADV
gs-4062	690	18	effective	effective	ADJ
gs-4062	690	19	option	option	NOUN
gs-4062	690	20	for	for	ADP
gs-4062	690	21	hiv	hiv	PROPN
gs-4062	690	22	prevention	prevention	NOUN
gs-4062	690	23	.	.	PUNCT
gs-4062	691	1	research	research	NOUN
gs-4062	691	2	into	into	ADP
gs-4062	691	3	even	even	ADV
gs-4062	691	4	longer	long	ADV
gs-4062	691	5	-	-	PUNCT
gs-4062	691	6	acting	act	VERB
gs-4062	691	7	modalities	modality	NOUN
gs-4062	691	8	is	be	AUX
gs-4062	691	9	underway	underway	ADJ
gs-4062	691	10	,	,	PUNCT
gs-4062	691	11	including	include	VERB
gs-4062	691	12	implantable	implantable	ADJ
gs-4062	691	13	devices	device	NOUN
gs-4062	691	14	that	that	PRON
gs-4062	691	15	could	could	AUX
gs-4062	691	16	deliver	deliver	VERB
gs-4062	691	17	antiretrovirals	antiretroviral	NOUN
gs-4062	691	18	for	for	ADP
gs-4062	691	19	a	a	DET
gs-4062	691	20	year	year	NOUN
gs-4062	691	21	or	or	CCONJ
gs-4062	691	22	more	more	ADJ
gs-4062	691	23	.	.	PUNCT
gs-4062	692	1	beyond	beyond	ADP
gs-4062	692	2	delivery	delivery	NOUN
gs-4062	692	3	systems	system	NOUN
gs-4062	692	4	,	,	PUNCT
gs-4062	692	5	novel	novel	ADJ
gs-4062	692	6	mechanisms	mechanism	NOUN
gs-4062	692	7	of	of	ADP
gs-4062	692	8	action	action	NOUN
gs-4062	692	9	are	be	AUX
gs-4062	692	10	being	be	AUX
gs-4062	692	11	explored	explore	VERB
gs-4062	692	12	.	.	PUNCT
gs-4062	693	1	maturation	maturation	NOUN
gs-4062	693	2	inhibitors	inhibitor	NOUN
gs-4062	693	3	,	,	PUNCT
gs-4062	693	4	which	which	PRON
gs-4062	693	5	target	target	VERB
gs-4062	693	6	a	a	DET
gs-4062	693	7	later	later	ADJ
gs-4062	693	8	stage	stage	NOUN
gs-4062	693	9	of	of	ADP
gs-4062	693	10	the	the	DET
gs-4062	693	11	viral	viral	ADJ
gs-4062	693	12	life	life	NOUN
gs-4062	693	13	cycle	cycle	NOUN
gs-4062	693	14	than	than	ADP
gs-4062	693	15	protease	protease	NOUN
gs-4062	693	16	inhibitors	inhibitor	NOUN
gs-4062	693	17	,	,	PUNCT
gs-4062	693	18	are	be	AUX
gs-4062	693	19	in	in	ADP
gs-4062	693	20	development	development	NOUN
gs-4062	693	21	.	.	PUNCT
gs-4062	694	1	broadly	broadly	ADV
gs-4062	694	2	neutralizing	neutralize	VERB
gs-4062	694	3	antibodies	antibody	NOUN
gs-4062	694	4	,	,	PUNCT
gs-4062	694	5	capable	capable	ADJ
gs-4062	694	6	of	of	ADP
gs-4062	694	7	targeting	target	VERB
gs-4062	694	8	a	a	DET
gs-4062	694	9	wide	wide	ADJ
gs-4062	694	10	range	range	NOUN
gs-4062	694	11	of	of	ADP
gs-4062	694	12	hiv	hiv	PROPN
gs-4062	694	13	strains	strain	VERB
gs-4062	694	14	by	by	ADP
gs-4062	694	15	recognizing	recognize	VERB
gs-4062	694	16	conserved	conserved	ADJ
gs-4062	694	17	regions	region	NOUN
gs-4062	694	18	of	of	ADP
gs-4062	694	19	the	the	DET
gs-4062	694	20	envelope	envelope	NOUN
gs-4062	694	21	protein	protein	NOUN
gs-4062	694	22	,	,	PUNCT
gs-4062	694	23	are	be	AUX
gs-4062	694	24	being	be	AUX
gs-4062	694	25	investigated	investigate	VERB
gs-4062	694	26	for	for	ADP
gs-4062	694	27	both	both	DET
gs-4062	694	28	treatment	treatment	NOUN
gs-4062	694	29	and	and	CCONJ
gs-4062	694	30	prevention	prevention	NOUN
gs-4062	694	31	,	,	PUNCT
gs-4062	694	32	potentially	potentially	ADV
gs-4062	694	33	offering	offer	VERB
gs-4062	694	34	long	long	ADJ
gs-4062	694	35	periods	period	NOUN
gs-4062	694	36	of	of	ADP
gs-4062	694	37	virologic	virologic	ADJ
gs-4062	694	38	control	control	NOUN
gs-4062	694	39	without	without	ADP
gs-4062	694	40	daily	daily	ADJ
gs-4062	694	41	medication	medication	NOUN
gs-4062	694	42	.	.	PUNCT
gs-4062	695	1	the	the	DET
gs-4062	695	2	ultimate	ultimate	ADJ
gs-4062	695	3	goal	goal	NOUN
gs-4062	695	4	remains	remain	VERB
gs-4062	695	5	a	a	DET
gs-4062	695	6	cure	cure	NOUN
gs-4062	695	7	—	—	PUNCT
gs-4062	695	8	a	a	DET
gs-4062	695	9	strategy	strategy	NOUN
gs-4062	695	10	to	to	PART
gs-4062	695	11	eradicate	eradicate	VERB
gs-4062	695	12	the	the	DET
gs-4062	695	13	reservoir	reservoir	NOUN
gs-4062	695	14	of	of	ADP
gs-4062	695	15	latently	latently	ADV
gs-4062	695	16	infected	infect	VERB
gs-4062	695	17	cells	cell	NOUN
gs-4062	695	18	that	that	PRON
gs-4062	695	19	persist	persist	VERB
gs-4062	695	20	despite	despite	SCONJ
gs-4062	695	21	effective	effective	ADJ
gs-4062	695	22	art	art	NOUN
gs-4062	695	23	.	.	PUNCT
gs-4062	696	1	strategies	strategy	NOUN
gs-4062	696	2	include	include	VERB
gs-4062	696	3	"	"	PUNCT
gs-4062	696	4	shock	shock	NOUN
gs-4062	696	5	and	and	CCONJ
gs-4062	696	6	kill	kill	VERB
gs-4062	696	7	,	,	PUNCT
gs-4062	696	8	"	"	PUNCT
gs-4062	696	9	using	use	VERB
gs-4062	696	10	latency	latency	NOUN
gs-4062	696	11	-	-	PUNCT
gs-4062	696	12	reversing	reverse	VERB
gs-4062	696	13	agents	agent	NOUN
gs-4062	696	14	to	to	PART
gs-4062	696	15	wake	wake	VERB
gs-4062	696	16	up	up	ADP
gs-4062	696	17	the	the	DET
gs-4062	696	18	dormant	dormant	ADJ
gs-4062	696	19	virus	virus	NOUN
gs-4062	696	20	so	so	SCONJ
gs-4062	696	21	it	it	PRON
gs-4062	696	22	can	can	AUX
gs-4062	696	23	be	be	AUX
gs-4062	696	24	targeted	target	VERB
gs-4062	696	25	by	by	ADP
gs-4062	696	26	the	the	DET
gs-4062	696	27	immune	immune	ADJ
gs-4062	696	28	system	system	NOUN
gs-4062	696	29	or	or	CCONJ
gs-4062	696	30	antiviral	antiviral	ADJ
gs-4062	696	31	drugs	drug	NOUN
gs-4062	696	32	,	,	PUNCT
gs-4062	696	33	and	and	CCONJ
gs-4062	696	34	"	"	PUNCT
gs-4062	696	35	block	block	NOUN
gs-4062	696	36	and	and	CCONJ
gs-4062	696	37	lock	lock	NOUN
gs-4062	696	38	,	,	PUNCT
gs-4062	696	39	"	"	PUNCT
gs-4062	696	40	which	which	PRON
gs-4062	696	41	aims	aim	VERB
gs-4062	696	42	to	to	PART
gs-4062	696	43	deepen	deepen	VERB
gs-4062	696	44	latency	latency	NOUN
gs-4062	696	45	into	into	ADP
gs-4062	696	46	a	a	DET
gs-4062	696	47	permanent	permanent	ADJ
gs-4062	696	48	state	state	NOUN
gs-4062	696	49	of	of	ADP
gs-4062	696	50	silence	silence	NOUN
gs-4062	696	51	.	.	PUNCT
gs-4062	697	1	gene	gene	NOUN
gs-4062	697	2	editing	edit	VERB
gs-4062	697	3	technologies	technology	NOUN
gs-4062	697	4	,	,	PUNCT
gs-4062	697	5	such	such	ADJ
gs-4062	697	6	as	as	ADP
gs-4062	697	7	crispr	crispr	NOUN
gs-4062	697	8	-	-	PUNCT
gs-4062	697	9	cas9	cas9	NOUN
gs-4062	697	10	,	,	PUNCT
gs-4062	697	11	are	be	AUX
gs-4062	697	12	being	be	AUX
gs-4062	697	13	explored	explore	VERB
gs-4062	697	14	to	to	PART
gs-4062	697	15	literally	literally	ADV
gs-4062	697	16	cut	cut	VERB
gs-4062	697	17	the	the	DET
gs-4062	697	18	proviral	proviral	ADJ
gs-4062	697	19	dna	dna	NOUN
gs-4062	697	20	out	out	ADP
gs-4062	697	21	of	of	ADP
gs-4062	697	22	the	the	DET
gs-4062	697	23	host	host	NOUN
gs-4062	697	24	genome	genome	NOUN
gs-4062	697	25	.	.	PUNCT
gs-4062	698	1	while	while	SCONJ
gs-4062	698	2	these	these	DET
gs-4062	698	3	approaches	approach	NOUN
gs-4062	698	4	remain	remain	VERB
gs-4062	698	5	experimental	experimental	ADJ
gs-4062	698	6	,	,	PUNCT
gs-4062	698	7	they	they	PRON
gs-4062	698	8	represent	represent	VERB
gs-4062	698	9	the	the	DET
gs-4062	698	10	vanguard	vanguard	NOUN
gs-4062	698	11	of	of	ADP
gs-4062	698	12	hiv	hiv	PROPN
gs-4062	698	13	research	research	NOUN
gs-4062	698	14	,	,	PUNCT
gs-4062	698	15	aiming	aim	VERB
gs-4062	698	16	to	to	PART
gs-4062	698	17	finally	finally	ADV
gs-4062	698	18	end	end	VERB
gs-4062	698	19	the	the	DET
gs-4062	698	20	epidemic	epidemic	NOUN
gs-4062	698	21	.	.	PUNCT
gs-4062	699	1	the	the	DET
gs-4062	699	2	relentless	relentless	ADJ
gs-4062	699	3	pursuit	pursuit	NOUN
gs-4062	699	4	of	of	ADP
gs-4062	699	5	scientific	scientific	ADJ
gs-4062	699	6	advancement	advancement	NOUN
gs-4062	699	7	in	in	ADP
gs-4062	699	8	antiretroviral	antiretroviral	ADJ
gs-4062	699	9	therapy	therapy	NOUN
gs-4062	699	10	has	have	AUX
gs-4062	699	11	ushered	usher	VERB
gs-4062	699	12	in	in	ADP
gs-4062	699	13	an	an	DET
gs-4062	699	14	epoch	epoch	NOUN
gs-4062	699	15	defined	define	VERB
gs-4062	699	16	not	not	PART
gs-4062	699	17	merely	merely	ADV
gs-4062	699	18	by	by	ADP
gs-4062	699	19	incremental	incremental	ADJ
gs-4062	699	20	improvement	improvement	NOUN
gs-4062	699	21	,	,	PUNCT
gs-4062	699	22	but	but	CCONJ
gs-4062	699	23	by	by	ADP
gs-4062	699	24	transformative	transformative	ADJ
gs-4062	699	25	leaps	leap	NOUN
gs-4062	699	26	that	that	PRON
gs-4062	699	27	are	be	AUX
gs-4062	699	28	redefining	redefine	VERB
gs-4062	699	29	the	the	DET
gs-4062	699	30	very	very	ADJ
gs-4062	699	31	essence	essence	NOUN
gs-4062	699	32	of	of	ADP
gs-4062	699	33	hiv	hiv	PROPN
gs-4062	699	34	management	management	NOUN
gs-4062	699	35	.	.	PUNCT
gs-4062	700	1	the	the	DET
gs-4062	700	2	synthesis	synthesis	NOUN
gs-4062	700	3	of	of	ADP
gs-4062	700	4	results	result	NOUN
gs-4062	700	5	from	from	ADP
gs-4062	700	6	pioneering	pioneer	VERB
gs-4062	700	7	clinical	clinical	ADJ
gs-4062	700	8	trials	trial	NOUN
gs-4062	700	9	,	,	PUNCT
gs-4062	700	10	sophisticated	sophisticated	ADJ
gs-4062	700	11	pharmacological	pharmacological	ADJ
gs-4062	700	12	analyses	analysis	NOUN
gs-4062	700	13	,	,	PUNCT
gs-4062	700	14	and	and	CCONJ
gs-4062	700	15	expansive	expansive	ADJ
gs-4062	700	16	real	real	ADJ
gs-4062	700	17	-	-	PUNCT
gs-4062	700	18	world	world	NOUN
gs-4062	700	19	evidence	evidence	NOUN
gs-4062	700	20	datasets	dataset	NOUN
gs-4062	700	21	reveals	reveal	VERB
gs-4062	700	22	a	a	DET
gs-4062	700	23	therapeutic	therapeutic	ADJ
gs-4062	700	24	landscape	landscape	NOUN
gs-4062	700	25	in	in	ADP
gs-4062	700	26	the	the	DET
gs-4062	700	27	midst	midst	NOUN
gs-4062	700	28	of	of	ADP
gs-4062	700	29	a	a	DET
gs-4062	700	30	profound	profound	ADJ
gs-4062	700	31	metamorphosis	metamorphosis	NOUN
gs-4062	700	32	.	.	PUNCT
gs-4062	701	1	this	this	DET
gs-4062	701	2	discussion	discussion	NOUN
gs-4062	701	3	delves	delve	VERB
gs-4062	701	4	beyond	beyond	ADP
gs-4062	701	5	the	the	DET
gs-4062	701	6	established	establish	VERB
gs-4062	701	7	narrative	narrative	NOUN
gs-4062	701	8	of	of	ADP
gs-4062	701	9	efficacy	efficacy	NOUN
gs-4062	701	10	and	and	CCONJ
gs-4062	701	11	safety	safety	NOUN
gs-4062	701	12	to	to	PART
gs-4062	701	13	explore	explore	VERB
gs-4062	701	14	the	the	DET
gs-4062	701	15	frontiers	frontier	NOUN
gs-4062	701	16	of	of	ADP
gs-4062	701	17	ultra	ultra	ADJ
gs-4062	701	18	-	-	ADJ
gs-4062	701	19	long	long	ADV
gs-4062	701	20	-	-	PUNCT
gs-4062	701	21	acting	act	VERB
gs-4062	701	22	delivery	delivery	NOUN
gs-4062	701	23	systems	system	NOUN
gs-4062	701	24	,	,	PUNCT
gs-4062	701	25	the	the	DET
gs-4062	701	26	nuanced	nuanced	ADJ
gs-4062	701	27	interplay	interplay	NOUN
gs-4062	701	28	between	between	ADP
gs-4062	701	29	host	host	NOUN
gs-4062	701	30	genetics	genetic	NOUN
gs-4062	701	31	and	and	CCONJ
gs-4062	701	32	drug	drug	NOUN
gs-4062	701	33	response	response	NOUN
gs-4062	701	34	,	,	PUNCT
gs-4062	701	35	the	the	DET
gs-4062	701	36	application	application	NOUN
gs-4062	701	37	of	of	ADP
gs-4062	701	38	artificial	artificial	ADJ
gs-4062	701	39	intelligence	intelligence	NOUN
gs-4062	701	40	in	in	ADP
gs-4062	701	41	predicting	predict	VERB
gs-4062	701	42	outcomes	outcome	NOUN
gs-4062	701	43	,	,	PUNCT
gs-4062	701	44	and	and	CCONJ
gs-4062	701	45	the	the	DET
gs-4062	701	46	bold	bold	ADJ
gs-4062	701	47	,	,	PUNCT
gs-4062	701	48	nascent	nascent	ADJ
gs-4062	701	49	steps	step	NOUN
gs-4062	701	50	toward	toward	ADP
gs-4062	701	51	curative	curative	ADJ
gs-4062	701	52	interventions	intervention	NOUN
gs-4062	701	53	.	.	PUNCT
gs-4062	702	1	the	the	DET
gs-4062	702	2	results	result	NOUN
gs-4062	702	3	presented	present	VERB
gs-4062	702	4	herein	herein	ADJ
gs-4062	702	5	paint	paint	NOUN
gs-4062	702	6	a	a	DET
gs-4062	702	7	picture	picture	NOUN
gs-4062	702	8	of	of	ADP
gs-4062	702	9	a	a	DET
gs-4062	702	10	field	field	NOUN
gs-4062	702	11	transitioning	transition	VERB
gs-4062	702	12	from	from	ADP
gs-4062	702	13	chronic	chronic	ADJ
gs-4062	702	14	suppression	suppression	NOUN
gs-4062	702	15	to	to	ADP
gs-4062	702	16	a	a	DET
gs-4062	702	17	future	future	NOUN
gs-4062	702	18	of	of	ADP
gs-4062	702	19	potential	potential	ADJ
gs-4062	702	20	remission	remission	NOUN
gs-4062	702	21	,	,	PUNCT
gs-4062	702	22	all	all	PRON
gs-4062	702	23	while	while	SCONJ
gs-4062	702	24	grappling	grapple	VERB
gs-4062	702	25	with	with	ADP
gs-4062	702	26	the	the	DET
gs-4062	702	27	formidable	formidable	ADJ
gs-4062	702	28	challenges	challenge	NOUN
gs-4062	702	29	of	of	ADP
gs-4062	702	30	equity	equity	NOUN
gs-4062	702	31	,	,	PUNCT
gs-4062	702	32	personalized	personalized	ADJ
gs-4062	702	33	medicine	medicine	NOUN
gs-4062	702	34	,	,	PUNCT
gs-4062	702	35	and	and	CCONJ
gs-4062	702	36	the	the	DET
gs-4062	702	37	long	long	ADJ
gs-4062	702	38	-	-	PUNCT
gs-4062	702	39	term	term	NOUN
gs-4062	702	40	biological	biological	ADJ
gs-4062	702	41	implications	implication	NOUN
gs-4062	702	42	of	of	ADP
gs-4062	702	43	half	half	DET
gs-4062	702	44	a	a	DET
gs-4062	702	45	century	century	NOUN
gs-4062	702	46	of	of	ADP
gs-4062	702	47	therapy	therapy	NOUN
gs-4062	702	48	.	.	PUNCT
gs-4062	703	1	the	the	DET
gs-4062	703	2	ascendancy	ascendancy	NOUN
gs-4062	703	3	of	of	ADP
gs-4062	703	4	second	second	ADJ
gs-4062	703	5	-	-	PUNCT
gs-4062	703	6	generation	generation	NOUN
gs-4062	703	7	integrase	integrase	NOUN
gs-4062	703	8	strand	strand	NOUN
gs-4062	703	9	transfer	transfer	NOUN
gs-4062	703	10	inhibitors	inhibitor	NOUN
gs-4062	703	11	has	have	AUX
gs-4062	703	12	solidified	solidify	VERB
gs-4062	703	13	into	into	ADP
gs-4062	703	14	a	a	DET
gs-4062	703	15	new	new	ADJ
gs-4062	703	16	standard	standard	NOUN
gs-4062	703	17	of	of	ADP
gs-4062	703	18	care	care	NOUN
gs-4062	703	19	,	,	PUNCT
gs-4062	703	20	but	but	CCONJ
gs-4062	703	21	the	the	DET
gs-4062	703	22	results	result	NOUN
gs-4062	703	23	now	now	ADV
gs-4062	703	24	extend	extend	VERB
gs-4062	703	25	far	far	ADV
gs-4062	703	26	beyond	beyond	ADP
gs-4062	703	27	their	their	PRON
gs-4062	703	28	well	well	ADV
gs-4062	703	29	-	-	PUNCT
gs-4062	703	30	documented	document	VERB
gs-4062	703	31	virological	virological	ADJ
gs-4062	703	32	superiority	superiority	NOUN
gs-4062	703	33	.	.	PUNCT
gs-4062	704	1	long	long	ADJ
gs-4062	704	2	-	-	PUNCT
gs-4062	704	3	term	term	NOUN
gs-4062	704	4	data	datum	NOUN
gs-4062	704	5	,	,	PUNCT
gs-4062	704	6	spanning	span	VERB
gs-4062	704	7	seven	seven	NUM
gs-4062	704	8	years	year	NOUN
gs-4062	704	9	and	and	CCONJ
gs-4062	704	10	more	more	ADJ
gs-4062	704	11	from	from	ADP
gs-4062	704	12	initial	initial	ADJ
gs-4062	704	13	clinical	clinical	ADJ
gs-4062	704	14	trials	trial	NOUN
gs-4062	704	15	,	,	PUNCT
gs-4062	704	16	provide	provide	VERB
gs-4062	704	17	an	an	DET
gs-4062	704	18	unprecedented	unprecedented	ADJ
gs-4062	704	19	view	view	NOUN
gs-4062	704	20	into	into	ADP
gs-4062	704	21	their	their	PRON
gs-4062	704	22	enduring	endure	VERB
gs-4062	704	23	impact	impact	NOUN
gs-4062	704	24	on	on	ADP
gs-4062	704	25	human	human	ADJ
gs-4062	704	26	physiology	physiology	NOUN
gs-4062	704	27	.	.	PUNCT
gs-4062	705	1	a	a	DET
gs-4062	705	2	critical	critical	ADJ
gs-4062	705	3	result	result	NOUN
gs-4062	705	4	emerging	emerge	VERB
gs-4062	705	5	from	from	ADP
gs-4062	705	6	these	these	DET
gs-4062	705	7	extended	extended	ADJ
gs-4062	705	8	studies	study	NOUN
gs-4062	705	9	is	be	AUX
gs-4062	705	10	the	the	DET
gs-4062	705	11	detailed	detailed	ADJ
gs-4062	705	12	characterization	characterization	NOUN
gs-4062	705	13	of	of	ADP
gs-4062	705	14	their	their	PRON
gs-4062	705	15	metabolic	metabolic	NOUN
gs-4062	705	16	profile	profile	NOUN
gs-4062	705	17	.	.	PUNCT
gs-4062	706	1	while	while	SCONJ
gs-4062	706	2	weight	weight	NOUN
gs-4062	706	3	georgian	georgian	NOUN
gs-4062	706	4	scientists/	scientists/	NUM
gs-4062	706	5	.	.	PUNCT
gs-4062	707	1	7	7	NUM
gs-4062	707	2	n	n	PRON
gs-4062	707	3	3	3	NUM
gs-4062	707	4	,	,	PUNCT
gs-4062	707	5	2025	2025	NUM
gs-4062	707	6	552	552	NUM
gs-4062	707	7	gain	gain	NOUN
gs-4062	707	8	has	have	AUX
gs-4062	707	9	been	be	AUX
gs-4062	707	10	widely	widely	ADV
gs-4062	707	11	discussed	discuss	VERB
gs-4062	707	12	,	,	PUNCT
gs-4062	707	13	more	more	ADV
gs-4062	707	14	nuanced	nuanced	ADJ
gs-4062	707	15	results	result	NOUN
gs-4062	707	16	differentiate	differentiate	VERB
gs-4062	707	17	the	the	DET
gs-4062	707	18	nature	nature	NOUN
gs-4062	707	19	of	of	ADP
gs-4062	707	20	this	this	DET
gs-4062	707	21	gain	gain	NOUN
gs-4062	707	22	.	.	PUNCT
gs-4062	708	1	sophisticated	sophisticated	ADJ
gs-4062	708	2	body	body	NOUN
gs-4062	708	3	composition	composition	NOUN
gs-4062	708	4	analyses	analysis	NOUN
gs-4062	708	5	using	use	VERB
gs-4062	708	6	dexa	dexa	NOUN
gs-4062	708	7	and	and	CCONJ
gs-4062	708	8	mri	mri	NOUN
gs-4062	708	9	scans	scan	NOUN
gs-4062	708	10	reveal	reveal	VERB
gs-4062	708	11	that	that	SCONJ
gs-4062	708	12	dolutegravir	dolutegravir	PRON
gs-4062	708	13	and	and	CCONJ
gs-4062	708	14	bictegravir	bictegravir	PROPN
gs-4062	708	15	are	be	AUX
gs-4062	708	16	associated	associate	VERB
gs-4062	708	17	with	with	ADP
gs-4062	708	18	a	a	DET
gs-4062	708	19	significant	significant	ADJ
gs-4062	708	20	increase	increase	NOUN
gs-4062	708	21	in	in	ADP
gs-4062	708	22	lean	lean	ADJ
gs-4062	708	23	body	body	NOUN
gs-4062	708	24	mass	mass	NOUN
gs-4062	708	25	,	,	PUNCT
gs-4062	708	26	not	not	PART
gs-4062	708	27	just	just	ADV
gs-4062	708	28	adiposity	adiposity	NOUN
gs-4062	708	29	.	.	PUNCT
gs-4062	709	1	this	this	PRON
gs-4062	709	2	is	be	AUX
gs-4062	709	3	a	a	DET
gs-4062	709	4	pivotal	pivotal	ADJ
gs-4062	709	5	distinction	distinction	NOUN
gs-4062	709	6	;	;	PUNCT
gs-4062	709	7	the	the	DET
gs-4062	709	8	clinical	clinical	ADJ
gs-4062	709	9	implications	implication	NOUN
gs-4062	709	10	of	of	ADP
gs-4062	709	11	gaining	gain	VERB
gs-4062	709	12	muscle	muscle	NOUN
gs-4062	709	13	mass	mass	NOUN
gs-4062	709	14	are	be	AUX
gs-4062	709	15	vastly	vastly	ADV
gs-4062	709	16	different	different	ADJ
gs-4062	709	17	from	from	ADP
gs-4062	709	18	those	those	PRON
gs-4062	709	19	associated	associate	VERB
gs-4062	709	20	with	with	ADP
gs-4062	709	21	pure	pure	ADJ
gs-4062	709	22	fat	fat	ADJ
gs-4062	709	23	accumulation	accumulation	NOUN
gs-4062	709	24	.	.	PUNCT
gs-4062	710	1	the	the	DET
gs-4062	710	2	discussion	discussion	NOUN
gs-4062	710	3	now	now	ADV
gs-4062	710	4	centers	center	VERB
gs-4062	710	5	on	on	ADP
gs-4062	710	6	whether	whether	SCONJ
gs-4062	710	7	this	this	PRON
gs-4062	710	8	represents	represent	VERB
gs-4062	710	9	an	an	DET
gs-4062	710	10	anabolic	anabolic	ADJ
gs-4062	710	11	effect	effect	NOUN
gs-4062	710	12	,	,	PUNCT
gs-4062	710	13	perhaps	perhaps	ADV
gs-4062	710	14	through	through	ADP
gs-4062	710	15	indirect	indirect	ADJ
gs-4062	710	16	mechanisms	mechanism	NOUN
gs-4062	710	17	involving	involve	VERB
gs-4062	710	18	improved	improve	VERB
gs-4062	710	19	overall	overall	ADJ
gs-4062	710	20	health	health	NOUN
gs-4062	710	21	and	and	CCONJ
gs-4062	710	22	reduced	reduced	ADJ
gs-4062	710	23	chronic	chronic	ADJ
gs-4062	710	24	inflammation	inflammation	NOUN
gs-4062	710	25	,	,	PUNCT
gs-4062	710	26	or	or	CCONJ
gs-4062	710	27	something	something	PRON
gs-4062	710	28	more	more	ADV
gs-4062	710	29	direct	direct	ADJ
gs-4062	710	30	.	.	PUNCT
gs-4062	711	1	concurrently	concurrently	ADV
gs-4062	711	2	,	,	PUNCT
gs-4062	711	3	results	result	VERB
gs-4062	711	4	from	from	ADP
gs-4062	711	5	large	large	ADJ
gs-4062	711	6	observational	observational	ADJ
gs-4062	711	7	cohorts	cohort	NOUN
gs-4062	711	8	like	like	ADP
gs-4062	711	9	the	the	DET
gs-4062	711	10	respond	respond	NOUN
gs-4062	711	11	study	study	NOUN
gs-4062	711	12	are	be	AUX
gs-4062	711	13	providing	provide	VERB
gs-4062	711	14	granularity	granularity	NOUN
gs-4062	711	15	on	on	ADP
gs-4062	711	16	the	the	DET
gs-4062	711	17	weight	weight	NOUN
gs-4062	711	18	trajectory	trajectory	NOUN
gs-4062	711	19	,	,	PUNCT
gs-4062	711	20	indicating	indicate	VERB
gs-4062	711	21	that	that	SCONJ
gs-4062	711	22	the	the	DET
gs-4062	711	23	rate	rate	NOUN
gs-4062	711	24	of	of	ADP
gs-4062	711	25	gain	gain	NOUN
gs-4062	711	26	plateaus	plateaus	NOUN
gs-4062	711	27	after	after	ADP
gs-4062	711	28	approximately	approximately	ADV
gs-4062	711	29	two	two	NUM
gs-4062	711	30	years	year	NOUN
gs-4062	711	31	,	,	PUNCT
gs-4062	711	32	offering	offer	VERB
gs-4062	711	33	reassurance	reassurance	NOUN
gs-4062	711	34	to	to	ADP
gs-4062	711	35	patients	patient	NOUN
gs-4062	711	36	and	and	CCONJ
gs-4062	711	37	clinicians	clinician	NOUN
gs-4062	711	38	concerned	concerned	ADJ
gs-4062	711	39	about	about	ADP
gs-4062	711	40	unbounded	unbounded	ADJ
gs-4062	711	41	increases	increase	NOUN
gs-4062	711	42	.	.	PUNCT
gs-4062	712	1	furthermore	furthermore	ADV
gs-4062	712	2	,	,	PUNCT
gs-4062	712	3	results	result	NOUN
gs-4062	712	4	investigating	investigate	VERB
gs-4062	712	5	the	the	DET
gs-4062	712	6	potential	potential	ADJ
gs-4062	712	7	moderating	moderate	VERB
gs-4062	712	8	effect	effect	NOUN
gs-4062	712	9	of	of	ADP
gs-4062	712	10	concomitant	concomitant	ADJ
gs-4062	712	11	nrtis	nrtis	PROPN
gs-4062	712	12	show	show	VERB
gs-4062	712	13	that	that	SCONJ
gs-4062	712	14	the	the	DET
gs-4062	712	15	weight	weight	NOUN
gs-4062	712	16	gain	gain	NOUN
gs-4062	712	17	effect	effect	NOUN
gs-4062	712	18	is	be	AUX
gs-4062	712	19	most	most	ADV
gs-4062	712	20	pronounced	pronounce	VERB
gs-4062	712	21	when	when	SCONJ
gs-4062	712	22	these	these	DET
gs-4062	712	23	instis	insti	NOUN
gs-4062	712	24	are	be	AUX
gs-4062	712	25	paired	pair	VERB
gs-4062	712	26	with	with	ADP
gs-4062	712	27	tenofovir	tenofovir	PROPN
gs-4062	712	28	alafenamide	alafenamide	PROPN
gs-4062	712	29	,	,	PUNCT
gs-4062	712	30	suggesting	suggest	VERB
gs-4062	712	31	a	a	DET
gs-4062	712	32	complex	complex	ADJ
gs-4062	712	33	drugdrug	drugdrug	NOUN
gs-4062	712	34	interaction	interaction	NOUN
gs-4062	712	35	that	that	PRON
gs-4062	712	36	potentiates	potentiate	VERB
gs-4062	712	37	this	this	DET
gs-4062	712	38	effect	effect	NOUN
gs-4062	712	39	,	,	PUNCT
gs-4062	712	40	a	a	DET
gs-4062	712	41	finding	finding	NOUN
gs-4062	712	42	that	that	PRON
gs-4062	712	43	is	be	AUX
gs-4062	712	44	reshaping	reshape	VERB
gs-4062	712	45	the	the	DET
gs-4062	712	46	rationale	rationale	NOUN
gs-4062	712	47	for	for	ADP
gs-4062	712	48	fixed	fix	VERB
gs-4062	712	49	-	-	PUNCT
gs-4062	712	50	dose	dose	NOUN
gs-4062	712	51	combination	combination	NOUN
gs-4062	712	52	development	development	NOUN
gs-4062	712	53	.	.	PUNCT
gs-4062	713	1	the	the	DET
gs-4062	713	2	pharmacological	pharmacological	ADJ
gs-4062	713	3	story	story	NOUN
gs-4062	713	4	of	of	ADP
gs-4062	713	5	tenofovir	tenofovir	PROPN
gs-4062	713	6	alafenamide	alafenamide	PROPN
gs-4062	713	7	continues	continue	VERB
gs-4062	713	8	to	to	PART
gs-4062	713	9	evolve	evolve	VERB
gs-4062	713	10	with	with	ADP
gs-4062	713	11	compelling	compelling	ADJ
gs-4062	713	12	new	new	ADJ
gs-4062	713	13	results	result	NOUN
gs-4062	713	14	regarding	regard	VERB
gs-4062	713	15	its	its	PRON
gs-4062	713	16	long	long	ADJ
gs-4062	713	17	-	-	PUNCT
gs-4062	713	18	term	term	NOUN
gs-4062	713	19	organ	organ	NOUN
gs-4062	713	20	safety	safety	NOUN
gs-4062	713	21	.	.	PUNCT
gs-4062	714	1	five	five	NUM
gs-4062	714	2	-	-	PUNCT
gs-4062	714	3	year	year	NOUN
gs-4062	714	4	data	datum	NOUN
gs-4062	714	5	from	from	ADP
gs-4062	714	6	registry	registry	NOUN
gs-4062	714	7	studies	study	NOUN
gs-4062	714	8	now	now	ADV
gs-4062	714	9	demonstrate	demonstrate	VERB
gs-4062	714	10	a	a	DET
gs-4062	714	11	statistically	statistically	ADV
gs-4062	714	12	significant	significant	ADJ
gs-4062	714	13	reduction	reduction	NOUN
gs-4062	714	14	in	in	ADP
gs-4062	714	15	the	the	DET
gs-4062	714	16	incidence	incidence	NOUN
gs-4062	714	17	of	of	ADP
gs-4062	714	18	end	end	NOUN
gs-4062	714	19	-	-	PUNCT
gs-4062	714	20	stage	stage	NOUN
gs-4062	714	21	renal	renal	ADJ
gs-4062	714	22	disease	disease	NOUN
gs-4062	714	23	and	and	CCONJ
gs-4062	714	24	fragility	fragility	NOUN
gs-4062	714	25	fractures	fracture	NOUN
gs-4062	714	26	compared	compare	VERB
gs-4062	714	27	to	to	ADP
gs-4062	714	28	cohorts	cohort	NOUN
gs-4062	714	29	historically	historically	ADV
gs-4062	714	30	treated	treat	VERB
gs-4062	714	31	with	with	ADP
gs-4062	714	32	tenofovir	tenofovir	NOUN
gs-4062	714	33	disoproxil	disoproxil	VERB
gs-4062	714	34	fumarate	fumarate	NOUN
gs-4062	714	35	.	.	PUNCT
gs-4062	715	1	however	however	ADV
gs-4062	715	2	,	,	PUNCT
gs-4062	715	3	a	a	DET
gs-4062	715	4	more	more	ADV
gs-4062	715	5	complex	complex	ADJ
gs-4062	715	6	and	and	CCONJ
gs-4062	715	7	concerning	concern	VERB
gs-4062	715	8	result	result	NOUN
gs-4062	715	9	has	have	AUX
gs-4062	715	10	emerged	emerge	VERB
gs-4062	715	11	regarding	regard	VERB
gs-4062	715	12	taf	taf	PROPN
gs-4062	715	13	's	's	PART
gs-4062	715	14	impact	impact	NOUN
gs-4062	715	15	on	on	ADP
gs-4062	715	16	lipid	lipid	ADJ
gs-4062	715	17	metabolism	metabolism	NOUN
gs-4062	715	18	.	.	PUNCT
gs-4062	716	1	while	while	SCONJ
gs-4062	716	2	it	it	PRON
gs-4062	716	3	is	be	AUX
gs-4062	716	4	renaland	renaland	VERB
gs-4062	716	5	bone	bone	NOUN
gs-4062	716	6	-	-	PUNCT
gs-4062	716	7	safe	safe	ADJ
gs-4062	716	8	,	,	PUNCT
gs-4062	716	9	taf	taf	PROPN
gs-4062	716	10	consistently	consistently	ADV
gs-4062	716	11	results	result	VERB
gs-4062	716	12	in	in	ADP
gs-4062	716	13	a	a	DET
gs-4062	716	14	greater	great	ADJ
gs-4062	716	15	increase	increase	NOUN
gs-4062	716	16	in	in	ADP
gs-4062	716	17	total	total	ADJ
gs-4062	716	18	cholesterol	cholesterol	NOUN
gs-4062	716	19	,	,	PUNCT
gs-4062	716	20	ldl	ldl	NOUN
gs-4062	716	21	cholesterol	cholesterol	NOUN
gs-4062	716	22	,	,	PUNCT
gs-4062	716	23	and	and	CCONJ
gs-4062	716	24	triglycerides	triglyceride	NOUN
gs-4062	716	25	than	than	ADP
gs-4062	716	26	tdf	tdf	PROPN
gs-4062	716	27	,	,	PUNCT
gs-4062	716	28	which	which	PRON
gs-4062	716	29	has	have	VERB
gs-4062	716	30	a	a	DET
gs-4062	716	31	lipid	lipid	NOUN
gs-4062	716	32	-	-	PUNCT
gs-4062	716	33	lowering	lower	VERB
gs-4062	716	34	effect	effect	NOUN
gs-4062	716	35	.	.	PUNCT
gs-4062	717	1	this	this	PRON
gs-4062	717	2	has	have	AUX
gs-4062	717	3	sparked	spark	VERB
gs-4062	717	4	a	a	DET
gs-4062	717	5	vigorous	vigorous	ADJ
gs-4062	717	6	discussion	discussion	NOUN
gs-4062	717	7	about	about	ADP
gs-4062	717	8	the	the	DET
gs-4062	717	9	long	long	ADJ
gs-4062	717	10	-	-	PUNCT
gs-4062	717	11	term	term	NOUN
gs-4062	717	12	cardiovascular	cardiovascular	ADJ
gs-4062	717	13	risk	risk	NOUN
gs-4062	717	14	profile	profile	NOUN
gs-4062	717	15	of	of	ADP
gs-4062	717	16	modern	modern	ADJ
gs-4062	717	17	regimens	regimen	NOUN
gs-4062	717	18	.	.	PUNCT
gs-4062	718	1	sophisticated	sophisticated	ADJ
gs-4062	718	2	risk	risk	NOUN
gs-4062	718	3	-	-	PUNCT
gs-4062	718	4	calculation	calculation	NOUN
gs-4062	718	5	models	model	NOUN
gs-4062	718	6	,	,	PUNCT
gs-4062	718	7	such	such	ADJ
gs-4062	718	8	as	as	ADP
gs-4062	718	9	the	the	DET
gs-4062	718	10	pooled	pool	VERB
gs-4062	718	11	cohort	cohort	NOUN
gs-4062	718	12	equations	equation	NOUN
gs-4062	718	13	and	and	CCONJ
gs-4062	718	14	d	d	NOUN
gs-4062	718	15	:	:	PUNCT
gs-4062	718	16	a	a	PRON
gs-4062	718	17	:	:	PUNCT
gs-4062	718	18	d	d	NOUN
gs-4062	718	19	risk	risk	NOUN
gs-4062	718	20	scores	score	NOUN
gs-4062	718	21	,	,	PUNCT
gs-4062	718	22	applied	apply	VERB
gs-4062	718	23	to	to	ADP
gs-4062	718	24	large	large	ADJ
gs-4062	718	25	patient	patient	ADJ
gs-4062	718	26	datasets	dataset	NOUN
gs-4062	718	27	,	,	PUNCT
gs-4062	718	28	yield	yield	VERB
gs-4062	718	29	a	a	DET
gs-4062	718	30	critical	critical	ADJ
gs-4062	718	31	result	result	NOUN
gs-4062	718	32	:	:	PUNCT
gs-4062	718	33	the	the	DET
gs-4062	718	34	absolute	absolute	ADJ
gs-4062	718	35	increase	increase	NOUN
gs-4062	718	36	in	in	ADP
gs-4062	718	37	cardiovascular	cardiovascular	ADJ
gs-4062	718	38	risk	risk	NOUN
gs-4062	718	39	from	from	ADP
gs-4062	718	40	taf	taf	PROPN
gs-4062	718	41	's	's	PART
gs-4062	718	42	dyslipidemia	dyslipidemia	NOUN
gs-4062	718	43	is	be	AUX
gs-4062	718	44	offset	offset	VERB
gs-4062	718	45	by	by	ADP
gs-4062	718	46	the	the	DET
gs-4062	718	47	overall	overall	ADJ
gs-4062	718	48	benefit	benefit	NOUN
gs-4062	718	49	of	of	ADP
gs-4062	718	50	improved	improve	VERB
gs-4062	718	51	viral	viral	ADJ
gs-4062	718	52	suppression	suppression	NOUN
gs-4062	718	53	,	,	PUNCT
gs-4062	718	54	better	well	ADJ
gs-4062	718	55	adherence	adherence	NOUN
gs-4062	718	56	,	,	PUNCT
gs-4062	718	57	and	and	CCONJ
gs-4062	718	58	the	the	DET
gs-4062	718	59	absence	absence	NOUN
gs-4062	718	60	of	of	ADP
gs-4062	718	61	renal	renal	ADJ
gs-4062	718	62	and	and	CCONJ
gs-4062	718	63	bone	bone	NOUN
gs-4062	718	64	toxicity	toxicity	NOUN
gs-4062	718	65	.	.	PUNCT
gs-4062	719	1	this	this	DET
gs-4062	719	2	nuanced	nuanced	ADJ
gs-4062	719	3	risk	risk	NOUN
gs-4062	719	4	-	-	PUNCT
gs-4062	719	5	benefit	benefit	NOUN
gs-4062	719	6	analysis	analysis	NOUN
gs-4062	719	7	is	be	AUX
gs-4062	719	8	a	a	DET
gs-4062	719	9	prime	prime	ADJ
gs-4062	719	10	example	example	NOUN
gs-4062	719	11	of	of	ADP
gs-4062	719	12	how	how	SCONJ
gs-4062	719	13	modern	modern	ADJ
gs-4062	719	14	hiv	hiv	PROPN
gs-4062	719	15	medicine	medicine	NOUN
gs-4062	719	16	must	must	AUX
gs-4062	719	17	balance	balance	VERB
gs-4062	719	18	competing	compete	VERB
gs-4062	719	19	physiological	physiological	ADJ
gs-4062	719	20	interests	interest	NOUN
gs-4062	719	21	,	,	PUNCT
gs-4062	719	22	moving	move	VERB
gs-4062	719	23	away	away	ADV
gs-4062	719	24	from	from	ADP
gs-4062	719	25	simplistic	simplistic	ADJ
gs-4062	719	26	notions	notion	NOUN
gs-4062	719	27	of	of	ADP
gs-4062	719	28	"	"	PUNCT
gs-4062	719	29	good	good	ADJ
gs-4062	719	30	"	"	PUNCT
gs-4062	719	31	or	or	CCONJ
gs-4062	719	32	"	"	PUNCT
gs-4062	719	33	bad	bad	ADJ
gs-4062	719	34	"	"	PUNCT
gs-4062	719	35	drugs	drug	NOUN
gs-4062	719	36	towards	towards	ADP
gs-4062	719	37	a	a	DET
gs-4062	719	38	more	more	ADV
gs-4062	719	39	holistic	holistic	ADJ
gs-4062	719	40	,	,	PUNCT
gs-4062	719	41	personalized	personalized	ADJ
gs-4062	719	42	assessment	assessment	NOUN
gs-4062	719	43	of	of	ADP
gs-4062	719	44	net	net	ADJ
gs-4062	719	45	health	health	NOUN
gs-4062	719	46	benefit	benefit	NOUN
gs-4062	719	47	for	for	ADP
gs-4062	719	48	each	each	DET
gs-4062	719	49	individual	individual	ADJ
gs-4062	719	50	patient	patient	NOUN
gs-4062	719	51	.	.	PUNCT
gs-4062	720	1	the	the	DET
gs-4062	720	2	most	most	ADJ
gs-4062	720	3	paradigm	paradigm	NOUN
gs-4062	720	4	-	-	PUNCT
gs-4062	720	5	shifting	shift	VERB
gs-4062	720	6	results	result	NOUN
gs-4062	720	7	emanate	emanate	VERB
gs-4062	720	8	from	from	ADP
gs-4062	720	9	the	the	DET
gs-4062	720	10	successful	successful	ADJ
gs-4062	720	11	deployment	deployment	NOUN
gs-4062	720	12	of	of	ADP
gs-4062	720	13	long	long	ADV
gs-4062	720	14	-	-	PUNCT
gs-4062	720	15	acting	act	VERB
gs-4062	720	16	injectable	injectable	ADJ
gs-4062	720	17	antiretroviral	antiretroviral	ADJ
gs-4062	720	18	therapy	therapy	NOUN
gs-4062	720	19	.	.	PUNCT
gs-4062	721	1	the	the	DET
gs-4062	721	2	outcomes	outcome	NOUN
gs-4062	721	3	from	from	ADP
gs-4062	721	4	the	the	DET
gs-4062	721	5	cares	care	NOUN
gs-4062	721	6	and	and	CCONJ
gs-4062	721	7	salsa	salsa	NOUN
gs-4062	721	8	studies	study	NOUN
gs-4062	721	9	,	,	PUNCT
gs-4062	721	10	which	which	PRON
gs-4062	721	11	evaluated	evaluate	VERB
gs-4062	721	12	the	the	DET
gs-4062	721	13	real	real	ADJ
gs-4062	721	14	-	-	PUNCT
gs-4062	721	15	world	world	NOUN
gs-4062	721	16	implementation	implementation	NOUN
gs-4062	721	17	of	of	ADP
gs-4062	721	18	cabotegravir	cabotegravir	PRON
gs-4062	721	19	and	and	CCONJ
gs-4062	721	20	rilpivirine	rilpivirine	VERB
gs-4062	721	21	injections	injection	NOUN
gs-4062	721	22	,	,	PUNCT
gs-4062	721	23	have	have	AUX
gs-4062	721	24	confirmed	confirm	VERB
gs-4062	721	25	the	the	DET
gs-4062	721	26	trial	trial	NOUN
gs-4062	721	27	results	result	NOUN
gs-4062	721	28	and	and	CCONJ
gs-4062	721	29	revealed	reveal	VERB
gs-4062	721	30	new	new	ADJ
gs-4062	721	31	,	,	PUNCT
gs-4062	721	32	practical	practical	ADJ
gs-4062	721	33	insights	insight	NOUN
gs-4062	721	34	.	.	PUNCT
gs-4062	722	1	a	a	DET
gs-4062	722	2	pivotal	pivotal	ADJ
gs-4062	722	3	result	result	NOUN
gs-4062	722	4	is	be	AUX
gs-4062	722	5	the	the	DET
gs-4062	722	6	importance	importance	NOUN
gs-4062	722	7	of	of	ADP
gs-4062	722	8	the	the	DET
gs-4062	722	9	leadin	leadin	NOUN
gs-4062	722	10	period	period	NOUN
gs-4062	722	11	with	with	ADP
gs-4062	722	12	oral	oral	ADJ
gs-4062	722	13	therapy	therapy	NOUN
gs-4062	722	14	.	.	PUNCT
gs-4062	723	1	patients	patient	NOUN
gs-4062	723	2	who	who	PRON
gs-4062	723	3	experienced	experience	VERB
gs-4062	723	4	even	even	ADV
gs-4062	723	5	minor	minor	ADJ
gs-4062	723	6	side	side	NOUN
gs-4062	723	7	effects	effect	NOUN
gs-4062	723	8	during	during	ADP
gs-4062	723	9	the	the	DET
gs-4062	723	10	oral	oral	ADJ
gs-4062	723	11	leadin	leadin	NOUN
gs-4062	723	12	were	be	AUX
gs-4062	723	13	significantly	significantly	ADV
gs-4062	723	14	more	more	ADV
gs-4062	723	15	likely	likely	ADJ
gs-4062	723	16	to	to	PART
gs-4062	723	17	discontinue	discontinue	VERB
gs-4062	723	18	the	the	DET
gs-4062	723	19	injectable	injectable	ADJ
gs-4062	723	20	regimen	regiman	NOUN
gs-4062	723	21	due	due	ADP
gs-4062	723	22	to	to	ADP
gs-4062	723	23	related	related	ADJ
gs-4062	723	24	side	side	NOUN
gs-4062	723	25	effects	effect	NOUN
gs-4062	723	26	,	,	PUNCT
gs-4062	723	27	providing	provide	VERB
gs-4062	723	28	a	a	DET
gs-4062	723	29	valuable	valuable	ADJ
gs-4062	723	30	predictive	predictive	ADJ
gs-4062	723	31	tool	tool	NOUN
gs-4062	723	32	for	for	ADP
gs-4062	723	33	clinicians	clinician	NOUN
gs-4062	723	34	.	.	PUNCT
gs-4062	724	1	furthermore	furthermore	ADV
gs-4062	724	2	,	,	PUNCT
gs-4062	724	3	results	result	NOUN
gs-4062	724	4	on	on	ADP
gs-4062	724	5	the	the	DET
gs-4062	724	6	management	management	NOUN
gs-4062	724	7	of	of	ADP
gs-4062	724	8	injection	injection	NOUN
gs-4062	724	9	site	site	NOUN
gs-4062	724	10	reactions	reaction	NOUN
gs-4062	724	11	(	(	PUNCT
gs-4062	724	12	isrs	isrs	PROPN
gs-4062	724	13	)	)	PUNCT
gs-4062	724	14	have	have	AUX
gs-4062	724	15	evolved	evolve	VERB
gs-4062	724	16	.	.	PUNCT
gs-4062	725	1	while	while	SCONJ
gs-4062	725	2	nearly	nearly	ADV
gs-4062	725	3	ubiquitous	ubiquitous	ADJ
gs-4062	725	4	,	,	PUNCT
gs-4062	725	5	the	the	DET
gs-4062	725	6	data	datum	NOUN
gs-4062	725	7	show	show	VERB
gs-4062	725	8	that	that	SCONJ
gs-4062	725	9	the	the	DET
gs-4062	725	10	severity	severity	NOUN
gs-4062	725	11	and	and	CCONJ
gs-4062	725	12	frequency	frequency	NOUN
gs-4062	725	13	of	of	ADP
gs-4062	725	14	isrs	isrs	ADJ
gs-4062	725	15	decrease	decrease	NOUN
gs-4062	725	16	markedly	markedly	ADV
gs-4062	725	17	over	over	ADP
gs-4062	725	18	time	time	NOUN
gs-4062	725	19	,	,	PUNCT
gs-4062	725	20	with	with	ADP
gs-4062	725	21	most	most	ADJ
gs-4062	725	22	patients	patient	NOUN
gs-4062	725	23	reporting	report	VERB
gs-4062	725	24	that	that	SCONJ
gs-4062	725	25	they	they	PRON
gs-4062	725	26	become	become	VERB
gs-4062	725	27	a	a	DET
gs-4062	725	28	minor	minor	ADJ
gs-4062	725	29	nuisance	nuisance	NOUN
gs-4062	725	30	rather	rather	ADV
gs-4062	725	31	than	than	ADP
gs-4062	725	32	a	a	DET
gs-4062	725	33	significant	significant	ADJ
gs-4062	725	34	barrier	barrier	NOUN
gs-4062	725	35	.	.	PUNCT
gs-4062	726	1	a	a	DET
gs-4062	726	2	fascinating	fascinating	ADJ
gs-4062	726	3	psychological	psychological	ADJ
gs-4062	726	4	result	result	NOUN
gs-4062	726	5	from	from	ADP
gs-4062	726	6	qualitative	qualitative	ADJ
gs-4062	726	7	sub	sub	NOUN
gs-4062	726	8	-	-	NOUN
gs-4062	726	9	studies	study	NOUN
gs-4062	726	10	is	be	AUX
gs-4062	726	11	that	that	SCONJ
gs-4062	726	12	many	many	ADJ
gs-4062	726	13	patients	patient	NOUN
gs-4062	726	14	begin	begin	VERB
gs-4062	726	15	to	to	PART
gs-4062	726	16	view	view	VERB
gs-4062	726	17	the	the	DET
gs-4062	726	18	post	post	ADJ
gs-4062	726	19	-	-	ADJ
gs-4062	726	20	injection	injection	ADJ
gs-4062	726	21	soreness	soreness	NOUN
gs-4062	726	22	as	as	ADP
gs-4062	726	23	a	a	DET
gs-4062	726	24	positive	positive	ADJ
gs-4062	726	25	,	,	PUNCT
gs-4062	726	26	tangible	tangible	ADJ
gs-4062	726	27	reminder	reminder	NOUN
gs-4062	726	28	of	of	ADP
gs-4062	726	29	their	their	PRON
gs-4062	726	30	months	month	NOUN
gs-4062	726	31	of	of	ADP
gs-4062	726	32	protection	protection	NOUN
gs-4062	726	33	,	,	PUNCT
gs-4062	726	34	reframing	reframe	VERB
gs-4062	726	35	the	the	DET
gs-4062	726	36	side	side	ADJ
gs-4062	726	37	effect	effect	NOUN
gs-4062	726	38	into	into	ADP
gs-4062	726	39	a	a	DET
gs-4062	726	40	symbol	symbol	NOUN
gs-4062	726	41	of	of	ADP
gs-4062	726	42	empowerment	empowerment	NOUN
gs-4062	726	43	and	and	CCONJ
gs-4062	726	44	freedom	freedom	NOUN
gs-4062	726	45	from	from	ADP
gs-4062	726	46	daily	daily	ADJ
gs-4062	726	47	pills	pill	NOUN
gs-4062	726	48	.	.	PUNCT
gs-4062	727	1	this	this	PRON
gs-4062	727	2	represents	represent	VERB
gs-4062	727	3	a	a	DET
gs-4062	727	4	profound	profound	ADJ
gs-4062	727	5	shift	shift	NOUN
gs-4062	727	6	in	in	ADP
gs-4062	727	7	the	the	DET
gs-4062	727	8	patient	patient	NOUN
gs-4062	727	9	-	-	PUNCT
gs-4062	727	10	clinician	clinician	NOUN
gs-4062	727	11	dialogue	dialogue	NOUN
gs-4062	727	12	,	,	PUNCT
gs-4062	727	13	from	from	ADP
gs-4062	727	14	merely	merely	ADV
gs-4062	727	15	tolerating	tolerate	VERB
gs-4062	727	16	side	side	ADJ
gs-4062	727	17	effects	effect	NOUN
gs-4062	727	18	to	to	ADP
gs-4062	727	19	finding	find	VERB
gs-4062	727	20	meaning	meaning	NOUN
gs-4062	727	21	and	and	CCONJ
gs-4062	727	22	value	value	NOUN
gs-4062	727	23	in	in	ADP
gs-4062	727	24	them	they	PRON
gs-4062	727	25	.	.	PUNCT
gs-4062	728	1	georgian	georgian	NOUN
gs-4062	728	2	scientists/	scientists/	NUM
gs-4062	728	3	.	.	PUNCT
gs-4062	729	1	7	7	NUM
gs-4062	729	2	n	n	PRON
gs-4062	729	3	3	3	NUM
gs-4062	729	4	,	,	PUNCT
gs-4062	729	5	2025	2025	NUM
gs-4062	729	6	553	553	NUM
gs-4062	729	7	the	the	DET
gs-4062	729	8	prevention	prevention	NOUN
gs-4062	729	9	landscape	landscape	NOUN
gs-4062	729	10	has	have	AUX
gs-4062	729	11	been	be	AUX
gs-4062	729	12	equally	equally	ADV
gs-4062	729	13	revolutionized	revolutionize	VERB
gs-4062	729	14	by	by	ADP
gs-4062	729	15	the	the	DET
gs-4062	729	16	results	result	NOUN
gs-4062	729	17	of	of	ADP
gs-4062	729	18	long	long	ADV
gs-4062	729	19	-	-	PUNCT
gs-4062	729	20	acting	act	VERB
gs-4062	729	21	cabotegravir	cabotegravir	NOUN
gs-4062	729	22	for	for	ADP
gs-4062	729	23	prep	prep	NOUN
gs-4062	729	24	.	.	PUNCT
gs-4062	730	1	the	the	DET
gs-4062	730	2	hptn	hptn	NOUN
gs-4062	730	3	084	084	NUM
gs-4062	730	4	trial	trial	NOUN
gs-4062	730	5	,	,	PUNCT
gs-4062	730	6	which	which	PRON
gs-4062	730	7	demonstrated	demonstrate	VERB
gs-4062	730	8	its	its	PRON
gs-4062	730	9	superiority	superiority	NOUN
gs-4062	730	10	to	to	ADP
gs-4062	730	11	oral	oral	ADJ
gs-4062	730	12	emtricitabine	emtricitabine	NOUN
gs-4062	730	13	/	/	SYM
gs-4062	730	14	tenofovir	tenofovir	PROPN
gs-4062	730	15	disoproxil	disoproxil	VERB
gs-4062	730	16	fumarate	fumarate	NOUN
gs-4062	730	17	in	in	ADP
gs-4062	730	18	cisgender	cisgender	PROPN
gs-4062	730	19	women	woman	NOUN
gs-4062	730	20	,	,	PUNCT
gs-4062	730	21	has	have	AUX
gs-4062	730	22	now	now	ADV
gs-4062	730	23	yielded	yield	VERB
gs-4062	730	24	results	result	NOUN
gs-4062	730	25	from	from	ADP
gs-4062	730	26	its	its	PRON
gs-4062	730	27	open	open	ADJ
gs-4062	730	28	-	-	PUNCT
gs-4062	730	29	label	label	NOUN
gs-4062	730	30	extension	extension	NOUN
gs-4062	730	31	phase	phase	NOUN
gs-4062	730	32	.	.	PUNCT
gs-4062	731	1	these	these	DET
gs-4062	731	2	results	result	NOUN
gs-4062	731	3	show	show	VERB
gs-4062	731	4	near	near	ADP
gs-4062	731	5	-	-	PUNCT
gs-4062	731	6	perfect	perfect	ADJ
gs-4062	731	7	efficacy	efficacy	NOUN
gs-4062	731	8	,	,	PUNCT
gs-4062	731	9	with	with	ADP
gs-4062	731	10	an	an	DET
gs-4062	731	11	hiv	hiv	PROPN
gs-4062	731	12	incidence	incidence	NOUN
gs-4062	731	13	rate	rate	NOUN
gs-4062	731	14	approaching	approach	VERB
gs-4062	731	15	zero	zero	NUM
gs-4062	731	16	,	,	PUNCT
gs-4062	731	17	solidifying	solidify	VERB
gs-4062	731	18	its	its	PRON
gs-4062	731	19	role	role	NOUN
gs-4062	731	20	as	as	ADP
gs-4062	731	21	a	a	DET
gs-4062	731	22	transformative	transformative	ADJ
gs-4062	731	23	tool	tool	NOUN
gs-4062	731	24	for	for	ADP
gs-4062	731	25	women	woman	NOUN
gs-4062	731	26	in	in	ADP
gs-4062	731	27	high	high	ADJ
gs-4062	731	28	-	-	PUNCT
gs-4062	731	29	incidence	incidence	NOUN
gs-4062	731	30	settings	setting	NOUN
gs-4062	731	31	.	.	PUNCT
gs-4062	732	1	however	however	ADV
gs-4062	732	2	,	,	PUNCT
gs-4062	732	3	a	a	DET
gs-4062	732	4	critical	critical	ADJ
gs-4062	732	5	discussion	discussion	NOUN
gs-4062	732	6	point	point	NOUN
gs-4062	732	7	has	have	AUX
gs-4062	732	8	emerged	emerge	VERB
gs-4062	732	9	from	from	ADP
gs-4062	732	10	these	these	DET
gs-4062	732	11	results	result	NOUN
gs-4062	732	12	:	:	PUNCT
gs-4062	732	13	the	the	DET
gs-4062	732	14	issue	issue	NOUN
gs-4062	732	15	of	of	ADP
gs-4062	732	16	integrase	integrase	NOUN
gs-4062	732	17	resistance	resistance	NOUN
gs-4062	732	18	upon	upon	SCONJ
gs-4062	732	19	breakthrough	breakthrough	NOUN
gs-4062	732	20	infection	infection	NOUN
gs-4062	732	21	.	.	PUNCT
gs-4062	733	1	several	several	ADJ
gs-4062	733	2	cases	case	NOUN
gs-4062	733	3	have	have	AUX
gs-4062	733	4	now	now	ADV
gs-4062	733	5	been	be	AUX
gs-4062	733	6	documented	document	VERB
gs-4062	733	7	where	where	SCONJ
gs-4062	733	8	individuals	individual	NOUN
gs-4062	733	9	acquired	acquire	VERB
gs-4062	733	10	hiv	hiv	PROPN
gs-4062	733	11	despite	despite	SCONJ
gs-4062	733	12	having	have	VERB
gs-4062	733	13	low	low	ADJ
gs-4062	733	14	but	but	CCONJ
gs-4062	733	15	detectable	detectable	ADJ
gs-4062	733	16	levels	level	NOUN
gs-4062	733	17	of	of	ADP
gs-4062	733	18	cabotegravir	cabotegravir	PROPN
gs-4062	733	19	,	,	PUNCT
gs-4062	733	20	and	and	CCONJ
gs-4062	733	21	the	the	DET
gs-4062	733	22	acquired	acquire	VERB
gs-4062	733	23	virus	virus	NOUN
gs-4062	733	24	possessed	possess	VERB
gs-4062	733	25	insti	insti	PROPN
gs-4062	733	26	resistance	resistance	NOUN
gs-4062	733	27	mutations	mutation	NOUN
gs-4062	733	28	,	,	PUNCT
gs-4062	733	29	including	include	VERB
gs-4062	733	30	to	to	ADP
gs-4062	733	31	dolutegravir	dolutegravir	PROPN
gs-4062	733	32	and	and	CCONJ
gs-4062	733	33	bictegravir	bictegravir	PROPN
gs-4062	733	34	.	.	PUNCT
gs-4062	734	1	this	this	DET
gs-4062	734	2	result	result	NOUN
gs-4062	734	3	has	have	VERB
gs-4062	734	4	urgent	urgent	ADJ
gs-4062	734	5	implications	implication	NOUN
gs-4062	734	6	for	for	ADP
gs-4062	734	7	clinical	clinical	ADJ
gs-4062	734	8	monitoring	monitoring	NOUN
gs-4062	734	9	protocols	protocol	NOUN
gs-4062	734	10	.	.	PUNCT
gs-4062	735	1	it	it	PRON
gs-4062	735	2	necessitates	necessitate	VERB
gs-4062	735	3	the	the	DET
gs-4062	735	4	development	development	NOUN
gs-4062	735	5	of	of	ADP
gs-4062	735	6	ultra	ultra	ADJ
gs-4062	735	7	-	-	ADJ
gs-4062	735	8	sensitive	sensitive	ADJ
gs-4062	735	9	point	point	NOUN
gs-4062	735	10	-	-	PUNCT
gs-4062	735	11	of	of	ADP
gs-4062	735	12	-	-	PUNCT
gs-4062	735	13	care	care	NOUN
gs-4062	735	14	tests	test	NOUN
gs-4062	735	15	for	for	ADP
gs-4062	735	16	hiv	hiv	PROPN
gs-4062	735	17	rna	rna	NOUN
gs-4062	735	18	that	that	PRON
gs-4062	735	19	can	can	AUX
gs-4062	735	20	detect	detect	VERB
gs-4062	735	21	infection	infection	NOUN
gs-4062	735	22	before	before	SCONJ
gs-4062	735	23	drug	drug	NOUN
gs-4062	735	24	levels	level	NOUN
gs-4062	735	25	wane	wane	VERB
gs-4062	735	26	too	too	ADV
gs-4062	735	27	far	far	ADV
gs-4062	735	28	,	,	PUNCT
gs-4062	735	29	and	and	CCONJ
gs-4062	735	30	it	it	PRON
gs-4062	735	31	mandates	mandate	VERB
gs-4062	735	32	rapid	rapid	ADJ
gs-4062	735	33	resistance	resistance	NOUN
gs-4062	735	34	testing	testing	NOUN
gs-4062	735	35	at	at	ADP
gs-4062	735	36	the	the	DET
gs-4062	735	37	first	first	ADJ
gs-4062	735	38	positive	positive	ADJ
gs-4062	735	39	result	result	NOUN
gs-4062	735	40	to	to	PART
gs-4062	735	41	guide	guide	VERB
gs-4062	735	42	the	the	DET
gs-4062	735	43	choice	choice	NOUN
gs-4062	735	44	of	of	ADP
gs-4062	735	45	a	a	DET
gs-4062	735	46	fully	fully	ADV
gs-4062	735	47	active	active	ADJ
gs-4062	735	48	regimen	regiman	NOUN
gs-4062	735	49	.	.	PUNCT
gs-4062	736	1	this	this	PRON
gs-4062	736	2	has	have	AUX
gs-4062	736	3	sparked	spark	VERB
gs-4062	736	4	a	a	DET
gs-4062	736	5	new	new	ADJ
gs-4062	736	6	field	field	NOUN
gs-4062	736	7	of	of	ADP
gs-4062	736	8	research	research	NOUN
gs-4062	736	9	into	into	ADP
gs-4062	736	10	"	"	PUNCT
gs-4062	736	11	resistance	resistance	NOUN
gs-4062	736	12	mitigation	mitigation	NOUN
gs-4062	736	13	strategies	strategy	NOUN
gs-4062	736	14	,	,	PUNCT
gs-4062	736	15	"	"	PUNCT
gs-4062	736	16	including	include	VERB
gs-4062	736	17	the	the	DET
gs-4062	736	18	use	use	NOUN
gs-4062	736	19	of	of	ADP
gs-4062	736	20	oral	oral	ADJ
gs-4062	736	21	tail	tail	NOUN
gs-4062	736	22	therapy	therapy	NOUN
gs-4062	736	23	with	with	ADP
gs-4062	736	24	a	a	DET
gs-4062	736	25	different	different	ADJ
gs-4062	736	26	drug	drug	NOUN
gs-4062	736	27	class	class	NOUN
gs-4062	736	28	and	and	CCONJ
gs-4062	736	29	more	more	ADV
gs-4062	736	30	frequent	frequent	ADJ
gs-4062	736	31	testing	testing	NOUN
gs-4062	736	32	during	during	ADP
gs-4062	736	33	the	the	DET
gs-4062	736	34	injection	injection	NOUN
gs-4062	736	35	tail	tail	NOUN
gs-4062	736	36	period	period	NOUN
gs-4062	736	37	.	.	PUNCT
gs-4062	737	1	the	the	DET
gs-4062	737	2	development	development	NOUN
gs-4062	737	3	of	of	ADP
gs-4062	737	4	lenacapavir	lenacapavir	PROPN
gs-4062	737	5	,	,	PUNCT
gs-4062	737	6	a	a	DET
gs-4062	737	7	first	first	ADJ
gs-4062	737	8	-	-	PUNCT
gs-4062	737	9	in	in	ADP
gs-4062	737	10	-	-	PUNCT
gs-4062	737	11	class	class	NOUN
gs-4062	737	12	capsid	capsid	NOUN
gs-4062	737	13	inhibitor	inhibitor	NOUN
gs-4062	737	14	,	,	PUNCT
gs-4062	737	15	represents	represent	VERB
gs-4062	737	16	one	one	NUM
gs-4062	737	17	of	of	ADP
gs-4062	737	18	the	the	DET
gs-4062	737	19	most	most	ADV
gs-4062	737	20	significant	significant	ADJ
gs-4062	737	21	therapeutic	therapeutic	ADJ
gs-4062	737	22	breakthroughs	breakthrough	NOUN
gs-4062	737	23	in	in	ADP
gs-4062	737	24	a	a	DET
gs-4062	737	25	decade	decade	NOUN
gs-4062	737	26	.	.	PUNCT
gs-4062	738	1	the	the	DET
gs-4062	738	2	pivotal	pivotal	ADJ
gs-4062	738	3	capella	capella	NOUN
gs-4062	738	4	trial	trial	NOUN
gs-4062	738	5	results	result	NOUN
gs-4062	738	6	in	in	ADP
gs-4062	738	7	heavily	heavily	ADV
gs-4062	738	8	treatment	treatment	NOUN
gs-4062	738	9	-	-	PUNCT
gs-4062	738	10	experienced	experience	VERB
gs-4062	738	11	patients	patient	NOUN
gs-4062	738	12	were	be	AUX
gs-4062	738	13	striking	strike	VERB
gs-4062	738	14	,	,	PUNCT
gs-4062	738	15	with	with	ADP
gs-4062	738	16	a	a	DET
gs-4062	738	17	majority	majority	NOUN
gs-4062	738	18	achieving	achieve	VERB
gs-4062	738	19	undetectable	undetectable	ADJ
gs-4062	738	20	viral	viral	ADJ
gs-4062	738	21	loads	load	NOUN
gs-4062	738	22	where	where	SCONJ
gs-4062	738	23	previous	previous	ADJ
gs-4062	738	24	regimens	regimen	NOUN
gs-4062	738	25	had	have	AUX
gs-4062	738	26	failed	fail	VERB
gs-4062	738	27	.	.	PUNCT
gs-4062	739	1	but	but	CCONJ
gs-4062	739	2	the	the	DET
gs-4062	739	3	newer	new	ADJ
gs-4062	739	4	results	result	NOUN
gs-4062	739	5	are	be	AUX
gs-4062	739	6	even	even	ADV
gs-4062	739	7	more	more	ADV
gs-4062	739	8	compelling	compelling	ADJ
gs-4062	739	9	.	.	PUNCT
gs-4062	740	1	phase	phase	NOUN
gs-4062	740	2	ii	ii	PROPN
gs-4062	740	3	/	/	SYM
gs-4062	740	4	iii	iii	PROPN
gs-4062	740	5	data	datum	NOUN
gs-4062	740	6	in	in	ADP
gs-4062	740	7	treatment	treatment	NOUN
gs-4062	740	8	-	-	PUNCT
gs-4062	740	9	naïve	naïve	ADJ
gs-4062	740	10	patient	patient	NOUN
gs-4062	740	11	’s	’s	PART
gs-4062	740	12	show	show	VERB
gs-4062	740	13	that	that	SCONJ
gs-4062	740	14	a	a	DET
gs-4062	740	15	combination	combination	NOUN
gs-4062	740	16	of	of	ADP
gs-4062	740	17	subcutaneous	subcutaneous	ADJ
gs-4062	740	18	lenacapavir	lenacapavir	NOUN
gs-4062	740	19	(	(	PUNCT
gs-4062	740	20	every	every	DET
gs-4062	740	21	six	six	NUM
gs-4062	740	22	months	month	NOUN
gs-4062	740	23	)	)	PUNCT
gs-4062	740	24	with	with	ADP
gs-4062	740	25	daily	daily	ADJ
gs-4062	740	26	oral	oral	ADJ
gs-4062	740	27	islatravir	islatravir	NOUN
gs-4062	740	28	(	(	PUNCT
gs-4062	740	29	a	a	DET
gs-4062	740	30	novel	novel	NOUN
gs-4062	740	31	nucleoside	nucleoside	NOUN
gs-4062	740	32	reverse	reverse	ADJ
gs-4062	740	33	transcriptase	transcriptase	NOUN
gs-4062	740	34	translocation	translocation	NOUN
gs-4062	740	35	inhibitor	inhibitor	NOUN
gs-4062	740	36	)	)	PUNCT
gs-4062	740	37	achieves	achieve	VERB
gs-4062	740	38	suppression	suppression	NOUN
gs-4062	740	39	rates	rate	NOUN
gs-4062	740	40	non	non	ADJ
gs-4062	740	41	-	-	ADJ
gs-4062	740	42	inferior	inferior	ADJ
gs-4062	740	43	to	to	ADP
gs-4062	740	44	standard	standard	ADJ
gs-4062	740	45	three	three	NUM
gs-4062	740	46	-	-	PUNCT
gs-4062	740	47	drug	drug	NOUN
gs-4062	740	48	daily	daily	ADJ
gs-4062	740	49	therapy	therapy	NOUN
gs-4062	740	50	.	.	PUNCT
gs-4062	741	1	this	this	DET
gs-4062	741	2	result	result	NOUN
gs-4062	741	3	is	be	AUX
gs-4062	741	4	the	the	DET
gs-4062	741	5	first	first	ADJ
gs-4062	741	6	concrete	concrete	ADJ
gs-4062	741	7	evidence	evidence	NOUN
gs-4062	741	8	that	that	SCONJ
gs-4062	741	9	a	a	DET
gs-4062	741	10	fully	fully	ADV
gs-4062	741	11	oral	oral	ADJ
gs-4062	741	12	,	,	PUNCT
gs-4062	741	13	long	long	ADV
gs-4062	741	14	-	-	PUNCT
gs-4062	741	15	acting	act	VERB
gs-4062	741	16	,	,	PUNCT
gs-4062	741	17	two	two	NUM
gs-4062	741	18	-	-	PUNCT
gs-4062	741	19	drug	drug	NOUN
gs-4062	741	20	regimen	regimen	NOUN
gs-4062	741	21	is	be	AUX
gs-4062	741	22	feasible	feasible	ADJ
gs-4062	741	23	.	.	PUNCT
gs-4062	742	1	the	the	DET
gs-4062	742	2	discussion	discussion	NOUN
gs-4062	742	3	surrounding	surround	VERB
gs-4062	742	4	lenacapavir	lenacapavir	NOUN
gs-4062	742	5	now	now	ADV
gs-4062	742	6	focuses	focus	VERB
gs-4062	742	7	on	on	ADP
gs-4062	742	8	its	its	PRON
gs-4062	742	9	unique	unique	ADJ
gs-4062	742	10	mechanism	mechanism	NOUN
gs-4062	742	11	.	.	PUNCT
gs-4062	743	1	biochemical	biochemical	ADJ
gs-4062	743	2	results	result	NOUN
gs-4062	743	3	show	show	VERB
gs-4062	743	4	it	it	PRON
gs-4062	743	5	not	not	PART
gs-4062	743	6	only	only	ADV
gs-4062	743	7	disrupts	disrupt	VERB
gs-4062	743	8	capsid	capsid	NOUN
gs-4062	743	9	uncoating	uncoating	NOUN
gs-4062	743	10	and	and	CCONJ
gs-4062	743	11	nuclear	nuclear	ADJ
gs-4062	743	12	import	import	NOUN
gs-4062	743	13	but	but	CCONJ
gs-4062	743	14	also	also	ADV
gs-4062	743	15	promotes	promote	VERB
gs-4062	743	16	the	the	DET
gs-4062	743	17	formation	formation	NOUN
gs-4062	743	18	of	of	ADP
gs-4062	743	19	aberrant	aberrant	NOUN
gs-4062	743	20	,	,	PUNCT
gs-4062	743	21	nonfunctional	nonfunctional	ADJ
gs-4062	743	22	capsids	capsid	NOUN
gs-4062	743	23	that	that	PRON
gs-4062	743	24	are	be	AUX
gs-4062	743	25	unable	unable	ADJ
gs-4062	743	26	to	to	PART
gs-4062	743	27	mature	mature	VERB
gs-4062	743	28	into	into	ADP
gs-4062	743	29	infectious	infectious	ADJ
gs-4062	743	30	virions	virion	NOUN
gs-4062	743	31	.	.	PUNCT
gs-4062	744	1	this	this	DET
gs-4062	744	2	multi	multi	ADJ
gs-4062	744	3	-	-	ADJ
gs-4062	744	4	stage	stage	ADJ
gs-4062	744	5	inhibition	inhibition	NOUN
gs-4062	744	6	creates	create	VERB
gs-4062	744	7	a	a	DET
gs-4062	744	8	formidable	formidable	ADJ
gs-4062	744	9	barrier	barrier	NOUN
gs-4062	744	10	to	to	ADP
gs-4062	744	11	resistance	resistance	NOUN
gs-4062	744	12	.	.	PUNCT
gs-4062	745	1	furthermore	furthermore	ADV
gs-4062	745	2	,	,	PUNCT
gs-4062	745	3	its	its	PRON
gs-4062	745	4	pharmacokinetic	pharmacokinetic	ADJ
gs-4062	745	5	profile	profile	NOUN
gs-4062	745	6	is	be	AUX
gs-4062	745	7	unparalleled	unparalleled	ADJ
gs-4062	745	8	;	;	PUNCT
gs-4062	745	9	its	its	PRON
gs-4062	745	10	half	half	ADJ
gs-4062	745	11	-	-	PUNCT
gs-4062	745	12	life	life	NOUN
gs-4062	745	13	of	of	ADP
gs-4062	745	14	over	over	ADP
gs-4062	745	15	ten	ten	NUM
gs-4062	745	16	weeks	week	NOUN
gs-4062	745	17	allows	allow	VERB
gs-4062	745	18	for	for	ADP
gs-4062	745	19	semi	semi	ADJ
gs-4062	745	20	-	-	ADJ
gs-4062	745	21	annual	annual	ADJ
gs-4062	745	22	dosing	dosing	NOUN
gs-4062	745	23	,	,	PUNCT
gs-4062	745	24	and	and	CCONJ
gs-4062	745	25	its	its	PRON
gs-4062	745	26	metabolism	metabolism	NOUN
gs-4062	745	27	is	be	AUX
gs-4062	745	28	independent	independent	ADJ
gs-4062	745	29	of	of	ADP
gs-4062	745	30	the	the	DET
gs-4062	745	31	cytochrome	cytochrome	ADJ
gs-4062	745	32	p450	p450	NUM
gs-4062	745	33	system	system	NOUN
gs-4062	745	34	,	,	PUNCT
gs-4062	745	35	rendering	render	VERB
gs-4062	745	36	it	it	PRON
gs-4062	745	37	virtually	virtually	ADV
gs-4062	745	38	free	free	ADJ
gs-4062	745	39	of	of	ADP
gs-4062	745	40	drug	drug	NOUN
gs-4062	745	41	-	-	PUNCT
gs-4062	745	42	drug	drug	NOUN
gs-4062	745	43	interactions	interaction	NOUN
gs-4062	745	44	—	—	PUNCT
gs-4062	745	45	a	a	DET
gs-4062	745	46	result	result	NOUN
gs-4062	745	47	that	that	PRON
gs-4062	745	48	is	be	AUX
gs-4062	745	49	a	a	DET
gs-4062	745	50	major	major	ADJ
gs-4062	745	51	advantage	advantage	NOUN
gs-4062	745	52	over	over	ADP
gs-4062	745	53	boosted	boost	VERB
gs-4062	745	54	protease	protease	NOUN
gs-4062	745	55	inhibitors	inhibitor	NOUN
gs-4062	745	56	and	and	CCONJ
gs-4062	745	57	some	some	DET
gs-4062	745	58	instis	instis	NOUN
gs-4062	745	59	.	.	PUNCT
gs-4062	746	1	the	the	DET
gs-4062	746	2	field	field	NOUN
gs-4062	746	3	of	of	ADP
gs-4062	746	4	broadly	broadly	ADV
gs-4062	746	5	neutralizing	neutralize	VERB
gs-4062	746	6	antibodies	antibody	NOUN
gs-4062	746	7	(	(	PUNCT
gs-4062	746	8	bnabs	bnab	NOUN
gs-4062	746	9	)	)	PUNCT
gs-4062	746	10	is	be	AUX
gs-4062	746	11	generating	generate	VERB
gs-4062	746	12	complex	complex	ADJ
gs-4062	746	13	and	and	CCONJ
gs-4062	746	14	fascinating	fascinating	ADJ
gs-4062	746	15	results	result	NOUN
gs-4062	746	16	that	that	PRON
gs-4062	746	17	are	be	AUX
gs-4062	746	18	charting	chart	VERB
gs-4062	746	19	a	a	DET
gs-4062	746	20	path	path	NOUN
gs-4062	746	21	toward	toward	ADP
gs-4062	746	22	both	both	CCONJ
gs-4062	746	23	advanced	advanced	ADJ
gs-4062	746	24	treatment	treatment	NOUN
gs-4062	746	25	and	and	CCONJ
gs-4062	746	26	cure	cure	NOUN
gs-4062	746	27	strategies	strategy	NOUN
gs-4062	746	28	.	.	PUNCT
gs-4062	747	1	the	the	DET
gs-4062	747	2	initial	initial	ADJ
gs-4062	747	3	results	result	NOUN
gs-4062	747	4	of	of	ADP
gs-4062	747	5	bnab	bnab	NOUN
gs-4062	747	6	monotherapy	monotherapy	NOUN
gs-4062	747	7	were	be	AUX
gs-4062	747	8	disappointing	disappointing	ADJ
gs-4062	747	9	due	due	ADJ
gs-4062	747	10	to	to	ADP
gs-4062	747	11	rapid	rapid	ADJ
gs-4062	747	12	viral	viral	ADJ
gs-4062	747	13	escape	escape	NOUN
gs-4062	747	14	.	.	PUNCT
gs-4062	748	1	however	however	ADV
gs-4062	748	2	,	,	PUNCT
gs-4062	748	3	combination	combination	NOUN
gs-4062	748	4	therapy	therapy	NOUN
gs-4062	748	5	with	with	ADP
gs-4062	748	6	two	two	NUM
gs-4062	748	7	or	or	CCONJ
gs-4062	748	8	three	three	NUM
gs-4062	748	9	bnabs	bnab	NOUN
gs-4062	748	10	targeting	target	VERB
gs-4062	748	11	non	non	ADJ
gs-4062	748	12	-	-	ADJ
gs-4062	748	13	overlapping	overlapping	ADJ
gs-4062	748	14	epitopes	epitope	NOUN
gs-4062	748	15	on	on	ADP
gs-4062	748	16	the	the	DET
gs-4062	748	17	hiv	hiv	PROPN
gs-4062	748	18	envelope	envelope	NOUN
gs-4062	748	19	has	have	AUX
gs-4062	748	20	yielded	yield	VERB
gs-4062	748	21	dramatically	dramatically	ADV
gs-4062	748	22	better	well	ADJ
gs-4062	748	23	results	result	NOUN
gs-4062	748	24	.	.	PUNCT
gs-4062	749	1	the	the	DET
gs-4062	749	2	antibody	antibody	NOUN
gs-4062	749	3	-	-	PUNCT
gs-4062	749	4	mediated	mediate	VERB
gs-4062	749	5	prevention	prevention	NOUN
gs-4062	749	6	(	(	PUNCT
gs-4062	749	7	amp	amp	PROPN
gs-4062	749	8	)	)	PUNCT
gs-4062	749	9	trials	trial	NOUN
gs-4062	749	10	and	and	CCONJ
gs-4062	749	11	subsequent	subsequent	ADJ
gs-4062	749	12	studies	study	NOUN
gs-4062	749	13	have	have	AUX
gs-4062	749	14	shown	show	VERB
gs-4062	749	15	that	that	PRON
gs-4062	749	16	combination	combination	NOUN
gs-4062	749	17	bnab	bnab	NOUN
gs-4062	749	18	infusions	infusion	NOUN
gs-4062	749	19	can	can	AUX
gs-4062	749	20	maintain	maintain	VERB
gs-4062	749	21	virological	virological	ADJ
gs-4062	749	22	suppression	suppression	NOUN
gs-4062	749	23	for	for	ADP
gs-4062	749	24	months	month	NOUN
gs-4062	749	25	in	in	ADP
gs-4062	749	26	selected	select	VERB
gs-4062	749	27	individuals	individual	NOUN
gs-4062	749	28	whose	whose	DET
gs-4062	749	29	virus	virus	NOUN
gs-4062	749	30	is	be	AUX
gs-4062	749	31	sensitive	sensitive	ADJ
gs-4062	749	32	to	to	ADP
gs-4062	749	33	the	the	DET
gs-4062	749	34	antibody	antibody	NOUN
gs-4062	749	35	cocktail	cocktail	NOUN
gs-4062	749	36	.	.	PUNCT
gs-4062	750	1	the	the	DET
gs-4062	750	2	most	most	ADV
gs-4062	750	3	exciting	exciting	ADJ
gs-4062	750	4	new	new	ADJ
gs-4062	750	5	results	result	NOUN
gs-4062	750	6	come	come	VERB
gs-4062	750	7	from	from	ADP
gs-4062	750	8	their	their	PRON
gs-4062	750	9	application	application	NOUN
gs-4062	750	10	in	in	ADP
gs-4062	750	11	cure	cure	NOUN
gs-4062	750	12	research	research	NOUN
gs-4062	750	13	.	.	PUNCT
gs-4062	751	1	in	in	ADP
gs-4062	751	2	a	a	DET
gs-4062	751	3	series	series	NOUN
gs-4062	751	4	of	of	ADP
gs-4062	751	5	elegant	elegant	ADJ
gs-4062	751	6	"	"	PUNCT
gs-4062	751	7	kickand	kickand	ADJ
gs-4062	751	8	-	-	PUNCT
gs-4062	751	9	kill	kill	NOUN
gs-4062	751	10	"	"	PUNCT
gs-4062	751	11	studies	study	NOUN
gs-4062	751	12	in	in	ADP
gs-4062	751	13	humanized	humanize	VERB
gs-4062	751	14	mouse	mouse	NOUN
gs-4062	751	15	models	model	NOUN
gs-4062	751	16	and	and	CCONJ
gs-4062	751	17	a	a	DET
gs-4062	751	18	handful	handful	NOUN
gs-4062	751	19	of	of	ADP
gs-4062	751	20	human	human	ADJ
gs-4062	751	21	clinical	clinical	ADJ
gs-4062	751	22	trials	trial	NOUN
gs-4062	751	23	,	,	PUNCT
gs-4062	751	24	the	the	DET
gs-4062	751	25	combination	combination	NOUN
gs-4062	751	26	of	of	ADP
gs-4062	751	27	a	a	DET
gs-4062	751	28	latency	latency	NOUN
gs-4062	751	29	-	-	PUNCT
gs-4062	751	30	reversing	reverse	VERB
gs-4062	751	31	agent	agent	NOUN
gs-4062	751	32	(	(	PUNCT
gs-4062	751	33	the	the	DET
gs-4062	751	34	"	"	PUNCT
gs-4062	751	35	kick	kick	NOUN
gs-4062	751	36	"	"	PUNCT
gs-4062	751	37	)	)	PUNCT
gs-4062	751	38	with	with	ADP
gs-4062	751	39	potent	potent	ADJ
gs-4062	751	40	bnabs	bnab	NOUN
gs-4062	751	41	(	(	PUNCT
gs-4062	751	42	the	the	DET
gs-4062	751	43	"	"	PUNCT
gs-4062	751	44	kill	kill	NOUN
gs-4062	751	45	"	"	PUNCT
gs-4062	751	46	)	)	PUNCT
gs-4062	751	47	has	have	AUX
gs-4062	751	48	shown	show	VERB
gs-4062	751	49	a	a	DET
gs-4062	751	50	measurable	measurable	ADJ
gs-4062	751	51	reduction	reduction	NOUN
gs-4062	751	52	in	in	ADP
gs-4062	751	53	the	the	DET
gs-4062	751	54	size	size	NOUN
gs-4062	751	55	of	of	ADP
gs-4062	751	56	the	the	DET
gs-4062	751	57	latent	latent	ADJ
gs-4062	751	58	viral	viral	ADJ
gs-4062	751	59	reservoir	reservoir	NOUN
gs-4062	751	60	.	.	PUNCT
gs-4062	752	1	the	the	DET
gs-4062	752	2	bnabs	bnabs	PROPN
gs-4062	752	3	act	act	VERB
gs-4062	752	4	by	by	ADP
gs-4062	752	5	binding	bind	VERB
gs-4062	752	6	to	to	ADP
gs-4062	752	7	viral	viral	ADJ
gs-4062	752	8	proteins	protein	NOUN
gs-4062	752	9	expressed	express	VERB
gs-4062	752	10	on	on	ADP
gs-4062	752	11	the	the	DET
gs-4062	752	12	surface	surface	NOUN
gs-4062	752	13	of	of	ADP
gs-4062	752	14	recently	recently	ADV
gs-4062	752	15	reactivated	reactivate	VERB
gs-4062	752	16	infected	infected	ADJ
gs-4062	752	17	cells	cell	NOUN
gs-4062	752	18	,	,	PUNCT
gs-4062	752	19	flagging	flag	VERB
gs-4062	752	20	them	they	PRON
gs-4062	752	21	for	for	ADP
gs-4062	752	22	destruction	destruction	NOUN
gs-4062	752	23	by	by	ADP
gs-4062	752	24	natural	natural	ADJ
gs-4062	752	25	killer	killer	NOUN
gs-4062	752	26	cells	cell	NOUN
gs-4062	752	27	through	through	ADP
gs-4062	752	28	antibody	antibody	NOUN
gs-4062	752	29	-	-	PUNCT
gs-4062	752	30	dependent	dependent	ADJ
gs-4062	752	31	cellular	cellular	ADJ
gs-4062	752	32	cytotoxicity	cytotoxicity	NOUN
gs-4062	752	33	(	(	PUNCT
gs-4062	752	34	adcc	adcc	NOUN
gs-4062	752	35	)	)	PUNCT
gs-4062	752	36	.	.	PUNCT
gs-4062	753	1	this	this	PRON
gs-4062	753	2	result	result	VERB
gs-4062	753	3	georgian	georgian	NOUN
gs-4062	753	4	scientists/	scientists/	NUM
gs-4062	753	5	.	.	PUNCT
gs-4062	754	1	7	7	NUM
gs-4062	754	2	n	n	PRON
gs-4062	754	3	3	3	NUM
gs-4062	754	4	,	,	PUNCT
gs-4062	754	5	2025	2025	NUM
gs-4062	754	6	554	554	NUM
gs-4062	754	7	provides	provide	VERB
gs-4062	754	8	a	a	DET
gs-4062	754	9	proof	proof	NOUN
gs-4062	754	10	-	-	PUNCT
gs-4062	754	11	of	of	ADP
gs-4062	754	12	-	-	PUNCT
gs-4062	754	13	concept	concept	NOUN
gs-4062	754	14	that	that	SCONJ
gs-4062	754	15	the	the	DET
gs-4062	754	16	immune	immune	ADJ
gs-4062	754	17	system	system	NOUN
gs-4062	754	18	can	can	AUX
gs-4062	754	19	be	be	AUX
gs-4062	754	20	harnessed	harness	VERB
gs-4062	754	21	to	to	ADP
gs-4062	754	22	clear	clear	ADJ
gs-4062	754	23	infected	infected	ADJ
gs-4062	754	24	cells	cell	NOUN
gs-4062	754	25	,	,	PUNCT
gs-4062	754	26	a	a	DET
gs-4062	754	27	crucial	crucial	ADJ
gs-4062	754	28	step	step	NOUN
gs-4062	754	29	towards	towards	ADP
gs-4062	754	30	a	a	DET
gs-4062	754	31	functional	functional	ADJ
gs-4062	754	32	cure	cure	NOUN
gs-4062	754	33	.	.	PUNCT
gs-4062	755	1	beyond	beyond	ADP
gs-4062	755	2	bnabs	bnab	NOUN
gs-4062	755	3	,	,	PUNCT
gs-4062	755	4	the	the	DET
gs-4062	755	5	cure	cure	NOUN
gs-4062	755	6	research	research	NOUN
gs-4062	755	7	landscape	landscape	NOUN
gs-4062	755	8	is	be	AUX
gs-4062	755	9	yielding	yield	VERB
gs-4062	755	10	results	result	NOUN
gs-4062	755	11	from	from	ADP
gs-4062	755	12	even	even	ADV
gs-4062	755	13	more	more	ADJ
gs-4062	755	14	novel	novel	ADJ
gs-4062	755	15	approaches	approach	NOUN
gs-4062	755	16	.	.	PUNCT
gs-4062	756	1	gene	gene	NOUN
gs-4062	756	2	editing	edit	VERB
gs-4062	756	3	technologies	technology	NOUN
gs-4062	756	4	,	,	PUNCT
gs-4062	756	5	particularly	particularly	ADV
gs-4062	756	6	crispr	crispr	ADJ
gs-4062	756	7	-	-	PUNCT
gs-4062	756	8	cas9	cas9	NOUN
gs-4062	756	9	,	,	PUNCT
gs-4062	756	10	have	have	AUX
gs-4062	756	11	moved	move	VERB
gs-4062	756	12	from	from	ADP
gs-4062	756	13	theory	theory	NOUN
gs-4062	756	14	to	to	ADP
gs-4062	756	15	early	early	ADJ
gs-4062	756	16	.	.	PUNCT
gs-4062	757	1	results	result	NOUN
gs-4062	757	2	from	from	ADP
gs-4062	757	3	ex	ex	PRON
gs-4062	757	4	vivo	vivo	ADJ
gs-4062	757	5	experiments	experiment	NOUN
gs-4062	757	6	show	show	VERB
gs-4062	757	7	that	that	SCONJ
gs-4062	757	8	crispr	crispr	ADJ
gs-4062	757	9	systems	system	NOUN
gs-4062	757	10	can	can	AUX
gs-4062	757	11	successfully	successfully	ADV
gs-4062	757	12	excise	excise	VERB
gs-4062	757	13	integrated	integrate	VERB
gs-4062	757	14	proviral	proviral	ADJ
gs-4062	757	15	dna	dna	NOUN
gs-4062	757	16	from	from	ADP
gs-4062	757	17	the	the	DET
gs-4062	757	18	genome	genome	NOUN
gs-4062	757	19	of	of	ADP
gs-4062	757	20	infected	infect	VERB
gs-4062	757	21	cd4	cd4	PROPN
gs-4062	757	22	+	+	PROPN
gs-4062	757	23	t	t	PROPN
gs-4062	757	24	-	-	PUNCT
gs-4062	757	25	cells	cell	NOUN
gs-4062	757	26	.	.	PUNCT
gs-4062	758	1	while	while	SCONJ
gs-4062	758	2	delivery	delivery	NOUN
gs-4062	758	3	of	of	ADP
gs-4062	758	4	these	these	DET
gs-4062	758	5	gene	gene	NOUN
gs-4062	758	6	editors	editor	NOUN
gs-4062	758	7	in	in	ADP
gs-4062	758	8	vivo	vivo	NOUN
gs-4062	758	9	remains	remain	VERB
gs-4062	758	10	a	a	DET
gs-4062	758	11	monumental	monumental	ADJ
gs-4062	758	12	challenge	challenge	NOUN
gs-4062	758	13	,	,	PUNCT
gs-4062	758	14	recent	recent	ADJ
gs-4062	758	15	results	result	NOUN
gs-4062	758	16	using	use	VERB
gs-4062	758	17	advanced	advanced	ADJ
gs-4062	758	18	viral	viral	ADJ
gs-4062	758	19	vectors	vector	NOUN
gs-4062	758	20	(	(	PUNCT
gs-4062	758	21	like	like	ADP
gs-4062	758	22	adenoassociated	adenoassociate	VERB
gs-4062	758	23	virus	virus	NOUN
gs-4062	758	24	)	)	PUNCT
gs-4062	758	25	or	or	CCONJ
gs-4062	758	26	lipid	lipid	NOUN
gs-4062	758	27	nanoparticles	nanoparticle	NOUN
gs-4062	758	28	(	(	PUNCT
gs-4062	758	29	similar	similar	ADJ
gs-4062	758	30	to	to	ADP
gs-4062	758	31	those	those	PRON
gs-4062	758	32	used	use	VERB
gs-4062	758	33	in	in	ADP
gs-4062	758	34	mrna	mrna	PROPN
gs-4062	758	35	covid-19	covid-19	PROPN
gs-4062	758	36	vaccines	vaccine	NOUN
gs-4062	758	37	)	)	PUNCT
gs-4062	758	38	have	have	AUX
gs-4062	758	39	shown	show	VERB
gs-4062	758	40	promise	promise	NOUN
gs-4062	758	41	in	in	ADP
gs-4062	758	42	animal	animal	NOUN
gs-4062	758	43	models	model	NOUN
gs-4062	758	44	.	.	PUNCT
gs-4062	759	1	another	another	DET
gs-4062	759	2	frontier	frontier	NOUN
gs-4062	759	3	is	be	AUX
gs-4062	759	4	the	the	DET
gs-4062	759	5	use	use	NOUN
gs-4062	759	6	of	of	ADP
gs-4062	759	7	therapeutic	therapeutic	ADJ
gs-4062	759	8	vaccines	vaccine	NOUN
gs-4062	759	9	to	to	PART
gs-4062	759	10	boost	boost	VERB
gs-4062	759	11	hivspecific	hivspecific	ADJ
gs-4062	759	12	immune	immune	ADJ
gs-4062	759	13	responses	response	NOUN
gs-4062	759	14	.	.	PUNCT
gs-4062	760	1	results	result	NOUN
gs-4062	760	2	from	from	ADP
gs-4062	760	3	the	the	DET
gs-4062	760	4	aelix-002	aelix-002	NOUN
gs-4062	760	5	trial	trial	NOUN
gs-4062	760	6	using	use	VERB
gs-4062	760	7	a	a	DET
gs-4062	760	8	combination	combination	NOUN
gs-4062	760	9	of	of	ADP
gs-4062	760	10	a	a	DET
gs-4062	760	11	dendritic	dendritic	ADJ
gs-4062	760	12	cell	cell	NOUN
gs-4062	760	13	vaccine	vaccine	NOUN
gs-4062	760	14	and	and	CCONJ
gs-4062	760	15	a	a	DET
gs-4062	760	16	viral	viral	ADJ
gs-4062	760	17	vector	vector	NOUN
gs-4062	760	18	vaccine	vaccine	NOUN
gs-4062	760	19	showed	show	VERB
gs-4062	760	20	that	that	SCONJ
gs-4062	760	21	a	a	DET
gs-4062	760	22	small	small	ADJ
gs-4062	760	23	subset	subset	NOUN
gs-4062	760	24	of	of	ADP
gs-4062	760	25	participants	participant	NOUN
gs-4062	760	26	who	who	PRON
gs-4062	760	27	underwent	undergo	VERB
gs-4062	760	28	analytical	analytical	ADJ
gs-4062	760	29	treatment	treatment	NOUN
gs-4062	760	30	interruption	interruption	NOUN
gs-4062	760	31	were	be	AUX
gs-4062	760	32	able	able	ADJ
gs-4062	760	33	to	to	PART
gs-4062	760	34	control	control	VERB
gs-4062	760	35	their	their	PRON
gs-4062	760	36	viral	viral	ADJ
gs-4062	760	37	load	load	NOUN
gs-4062	760	38	without	without	ADP
gs-4062	760	39	art	art	NOUN
gs-4062	760	40	for	for	ADP
gs-4062	760	41	several	several	ADJ
gs-4062	760	42	months	month	NOUN
gs-4062	760	43	.	.	PUNCT
gs-4062	761	1	although	although	SCONJ
gs-4062	761	2	not	not	PART
gs-4062	761	3	a	a	DET
gs-4062	761	4	cure	cure	NOUN
gs-4062	761	5	,	,	PUNCT
gs-4062	761	6	this	this	DET
gs-4062	761	7	result	result	NOUN
gs-4062	761	8	of	of	ADP
gs-4062	761	9	"	"	PUNCT
gs-4062	761	10	durable	durable	ADJ
gs-4062	761	11	virological	virological	ADJ
gs-4062	761	12	control	control	NOUN
gs-4062	761	13	"	"	PUNCT
gs-4062	761	14	is	be	AUX
gs-4062	761	15	a	a	DET
gs-4062	761	16	significant	significant	ADJ
gs-4062	761	17	milestone	milestone	NOUN
gs-4062	761	18	,	,	PUNCT
gs-4062	761	19	suggesting	suggest	VERB
gs-4062	761	20	that	that	SCONJ
gs-4062	761	21	immune	immune	NOUN
gs-4062	761	22	-	-	PUNCT
gs-4062	761	23	mediated	mediate	VERB
gs-4062	761	24	remission	remission	NOUN
gs-4062	761	25	is	be	AUX
gs-4062	761	26	a	a	DET
gs-4062	761	27	plausible	plausible	ADJ
gs-4062	761	28	goal	goal	NOUN
gs-4062	761	29	.	.	PUNCT
gs-4062	762	1	the	the	DET
gs-4062	762	2	scientific	scientific	ADJ
gs-4062	762	3	discussion	discussion	NOUN
gs-4062	762	4	surrounding	surround	VERB
gs-4062	762	5	new	new	ADJ
gs-4062	762	6	anti	anti	ADJ
gs-4062	762	7	-	-	ADJ
gs-4062	762	8	hiv	hiv	ADJ
gs-4062	762	9	medicines	medicine	NOUN
gs-4062	762	10	is	be	AUX
gs-4062	762	11	a	a	DET
gs-4062	762	12	testament	testament	NOUN
gs-4062	762	13	to	to	ADP
gs-4062	762	14	decades	decade	NOUN
gs-4062	762	15	of	of	ADP
gs-4062	762	16	collaborative	collaborative	ADJ
gs-4062	762	17	,	,	PUNCT
gs-4062	762	18	multidisciplinary	multidisciplinary	ADJ
gs-4062	762	19	effort	effort	NOUN
gs-4062	762	20	.	.	PUNCT
gs-4062	763	1	it	it	PRON
gs-4062	763	2	is	be	AUX
gs-4062	763	3	a	a	DET
gs-4062	763	4	narrative	narrative	NOUN
gs-4062	763	5	of	of	ADP
gs-4062	763	6	progress	progress	NOUN
gs-4062	763	7	,	,	PUNCT
gs-4062	763	8	from	from	ADP
gs-4062	763	9	blunt	blunt	ADJ
gs-4062	763	10	cytotoxic	cytotoxic	ADJ
gs-4062	763	11	agents	agent	NOUN
gs-4062	763	12	to	to	PART
gs-4062	763	13	exquisitely	exquisitely	ADV
gs-4062	763	14	targeted	target	VERB
gs-4062	763	15	molecular	molecular	ADJ
gs-4062	763	16	therapeutics	therapeutic	NOUN
gs-4062	763	17	.	.	PUNCT
gs-4062	764	1	this	this	DET
gs-4062	764	2	discourse	discourse	NOUN
gs-4062	764	3	,	,	PUNCT
gs-4062	764	4	encompassing	encompass	VERB
gs-4062	764	5	precise	precise	ADJ
gs-4062	764	6	classification	classification	NOUN
gs-4062	764	7	,	,	PUNCT
gs-4062	764	8	detailed	detailed	ADJ
gs-4062	764	9	mechanistic	mechanistic	ADJ
gs-4062	764	10	understanding	understanding	NOUN
gs-4062	764	11	,	,	PUNCT
gs-4062	764	12	sophisticated	sophisticated	ADJ
gs-4062	764	13	pharmacology	pharmacology	NOUN
gs-4062	764	14	,	,	PUNCT
gs-4062	764	15	and	and	CCONJ
gs-4062	764	16	evidence	evidence	NOUN
gs-4062	764	17	-	-	PUNCT
gs-4062	764	18	based	base	VERB
gs-4062	764	19	clinical	clinical	ADJ
gs-4062	764	20	application	application	NOUN
gs-4062	764	21	,	,	PUNCT
gs-4062	764	22	has	have	AUX
gs-4062	764	23	transformed	transform	VERB
gs-4062	764	24	hiv	hiv	PROPN
gs-4062	764	25	care	care	NOUN
gs-4062	764	26	.	.	PUNCT
gs-4062	765	1	the	the	DET
gs-4062	765	2	balance	balance	NOUN
gs-4062	765	3	between	between	ADP
gs-4062	765	4	profound	profound	ADJ
gs-4062	765	5	life	life	NOUN
gs-4062	765	6	-	-	PUNCT
gs-4062	765	7	saving	save	VERB
gs-4062	765	8	effects	effect	NOUN
gs-4062	765	9	and	and	CCONJ
gs-4062	765	10	manageable	manageable	ADJ
gs-4062	765	11	toxicities	toxicity	NOUN
gs-4062	765	12	is	be	AUX
gs-4062	765	13	constantly	constantly	ADV
gs-4062	765	14	being	be	AUX
gs-4062	765	15	refined	refine	VERB
gs-4062	765	16	.	.	PUNCT
gs-4062	766	1	as	as	SCONJ
gs-4062	766	2	long	long	ADV
gs-4062	766	3	-	-	PUNCT
gs-4062	766	4	acting	act	VERB
gs-4062	766	5	therapies	therapy	NOUN
gs-4062	766	6	redefine	redefine	VERB
gs-4062	766	7	convenience	convenience	NOUN
gs-4062	766	8	and	and	CCONJ
gs-4062	766	9	novel	novel	ADJ
gs-4062	766	10	mechanisms	mechanism	NOUN
gs-4062	766	11	offer	offer	VERB
gs-4062	766	12	new	new	ADJ
gs-4062	766	13	hope	hope	NOUN
gs-4062	766	14	,	,	PUNCT
gs-4062	766	15	the	the	DET
gs-4062	766	16	scientific	scientific	ADJ
gs-4062	766	17	conversation	conversation	NOUN
gs-4062	766	18	grows	grow	VERB
gs-4062	766	19	ever	ever	ADV
gs-4062	766	20	more	more	ADV
gs-4062	766	21	complex	complex	ADJ
gs-4062	766	22	and	and	CCONJ
gs-4062	766	23	promising	promising	ADJ
gs-4062	766	24	.	.	PUNCT
gs-4062	767	1	this	this	DET
gs-4062	767	2	ongoing	ongoing	ADJ
gs-4062	767	3	manifestation	manifestation	NOUN
gs-4062	767	4	of	of	ADP
gs-4062	767	5	knowledge	knowledge	NOUN
gs-4062	767	6	ensures	ensure	VERB
gs-4062	767	7	that	that	SCONJ
gs-4062	767	8	the	the	DET
gs-4062	767	9	response	response	NOUN
gs-4062	767	10	to	to	ADP
gs-4062	767	11	hiv	hiv	PROPN
gs-4062	767	12	remains	remain	VERB
gs-4062	767	13	dynamic	dynamic	ADJ
gs-4062	767	14	,	,	PUNCT
gs-4062	767	15	patient	patient	NOUN
gs-4062	767	16	-	-	PUNCT
gs-4062	767	17	centered	center	VERB
gs-4062	767	18	,	,	PUNCT
gs-4062	767	19	and	and	CCONJ
gs-4062	767	20	relentlessly	relentlessly	ADV
gs-4062	767	21	focused	focus	VERB
gs-4062	767	22	on	on	ADP
gs-4062	767	23	improving	improve	VERB
gs-4062	767	24	the	the	DET
gs-4062	767	25	lives	life	NOUN
gs-4062	767	26	of	of	ADP
gs-4062	767	27	millions	million	NOUN
gs-4062	767	28	of	of	ADP
gs-4062	767	29	people	people	NOUN
gs-4062	767	30	around	around	ADP
gs-4062	767	31	the	the	DET
gs-4062	767	32	world	world	NOUN
gs-4062	767	33	.	.	PUNCT
gs-4062	768	1	the	the	DET
gs-4062	768	2	results	result	NOUN
gs-4062	768	3	presented	present	VERB
gs-4062	768	4	in	in	ADP
gs-4062	768	5	the	the	DET
gs-4062	768	6	preceding	precede	VERB
gs-4062	768	7	section	section	NOUN
gs-4062	768	8	illuminate	illuminate	VERB
gs-4062	768	9	a	a	DET
gs-4062	768	10	period	period	NOUN
gs-4062	768	11	of	of	ADP
gs-4062	768	12	unprecedented	unprecedented	ADJ
gs-4062	768	13	innovation	innovation	NOUN
gs-4062	768	14	and	and	CCONJ
gs-4062	768	15	paradigm	paradigm	NOUN
gs-4062	768	16	shift	shift	NOUN
gs-4062	768	17	in	in	ADP
gs-4062	768	18	the	the	DET
gs-4062	768	19	management	management	NOUN
gs-4062	768	20	of	of	ADP
gs-4062	768	21	human	human	ADJ
gs-4062	768	22	immunodeficiency	immunodeficiency	NOUN
gs-4062	768	23	virus	virus	NOUN
gs-4062	768	24	infection	infection	NOUN
gs-4062	768	25	.	.	PUNCT
gs-4062	769	1	the	the	DET
gs-4062	769	2	transition	transition	NOUN
gs-4062	769	3	from	from	ADP
gs-4062	769	4	the	the	DET
gs-4062	769	5	historic	historic	ADJ
gs-4062	769	6	goal	goal	NOUN
gs-4062	769	7	of	of	ADP
gs-4062	769	8	survival	survival	NOUN
gs-4062	769	9	to	to	ADP
gs-4062	769	10	the	the	DET
gs-4062	769	11	contemporary	contemporary	ADJ
gs-4062	769	12	objectives	objective	NOUN
gs-4062	769	13	of	of	ADP
gs-4062	769	14	holistic	holistic	ADJ
gs-4062	769	15	health	health	NOUN
gs-4062	769	16	,	,	PUNCT
gs-4062	769	17	normalcy	normalcy	NOUN
gs-4062	769	18	,	,	PUNCT
gs-4062	769	19	and	and	CCONJ
gs-4062	769	20	potential	potential	ADJ
gs-4062	769	21	remission	remission	NOUN
gs-4062	769	22	represents	represent	VERB
gs-4062	769	23	the	the	DET
gs-4062	769	24	culmination	culmination	NOUN
gs-4062	769	25	of	of	ADP
gs-4062	769	26	four	four	NUM
gs-4062	769	27	decades	decade	NOUN
gs-4062	769	28	of	of	ADP
gs-4062	769	29	scientific	scientific	ADJ
gs-4062	769	30	perseverance	perseverance	NOUN
gs-4062	769	31	.	.	PUNCT
gs-4062	770	1	this	this	DET
gs-4062	770	2	discussion	discussion	NOUN
gs-4062	770	3	aims	aim	VERB
gs-4062	770	4	to	to	PART
gs-4062	770	5	synthesize	synthesize	VERB
gs-4062	770	6	these	these	DET
gs-4062	770	7	complex	complex	ADJ
gs-4062	770	8	findings	finding	NOUN
gs-4062	770	9	,	,	PUNCT
gs-4062	770	10	moving	move	VERB
gs-4062	770	11	beyond	beyond	ADP
gs-4062	770	12	a	a	DET
gs-4062	770	13	mere	mere	ADJ
gs-4062	770	14	recapitulation	recapitulation	NOUN
gs-4062	770	15	of	of	ADP
gs-4062	770	16	efficacy	efficacy	NOUN
gs-4062	770	17	and	and	CCONJ
gs-4062	770	18	safety	safety	NOUN
gs-4062	770	19	data	datum	NOUN
gs-4062	770	20	to	to	PART
gs-4062	770	21	engage	engage	VERB
gs-4062	770	22	in	in	ADP
gs-4062	770	23	a	a	DET
gs-4062	770	24	critical	critical	ADJ
gs-4062	770	25	,	,	PUNCT
gs-4062	770	26	multi	multi	ADJ
gs-4062	770	27	-	-	ADJ
gs-4062	770	28	faceted	faceted	ADJ
gs-4062	770	29	analysis	analysis	NOUN
gs-4062	770	30	of	of	ADP
gs-4062	770	31	what	what	PRON
gs-4062	770	32	these	these	DET
gs-4062	770	33	advancements	advancement	NOUN
gs-4062	770	34	truly	truly	ADV
gs-4062	770	35	mean	mean	VERB
gs-4062	770	36	for	for	ADP
gs-4062	770	37	patients	patient	NOUN
gs-4062	770	38	,	,	PUNCT
gs-4062	770	39	clinicians	clinician	NOUN
gs-4062	770	40	,	,	PUNCT
gs-4062	770	41	public	public	ADJ
gs-4062	770	42	health	health	NOUN
gs-4062	770	43	systems	system	NOUN
gs-4062	770	44	,	,	PUNCT
gs-4062	770	45	and	and	CCONJ
gs-4062	770	46	the	the	DET
gs-4062	770	47	future	future	ADJ
gs-4062	770	48	trajectory	trajectory	NOUN
gs-4062	770	49	of	of	ADP
gs-4062	770	50	the	the	DET
gs-4062	770	51	hiv	hiv	PROPN
gs-4062	770	52	epidemic	epidemic	NOUN
gs-4062	770	53	.	.	PUNCT
gs-4062	771	1	we	we	PRON
gs-4062	771	2	will	will	AUX
gs-4062	771	3	explore	explore	VERB
gs-4062	771	4	the	the	DET
gs-4062	771	5	profound	profound	ADJ
gs-4062	771	6	implications	implication	NOUN
gs-4062	771	7	of	of	ADP
gs-4062	771	8	long	long	ADV
gs-4062	771	9	-	-	PUNCT
gs-4062	771	10	acting	act	VERB
gs-4062	771	11	therapies	therapy	NOUN
gs-4062	771	12	,	,	PUNCT
gs-4062	771	13	deconstruct	deconstruct	VERB
gs-4062	771	14	the	the	DET
gs-4062	771	15	challenges	challenge	NOUN
gs-4062	771	16	and	and	CCONJ
gs-4062	771	17	opportunities	opportunity	NOUN
gs-4062	771	18	presented	present	VERB
gs-4062	771	19	by	by	ADP
gs-4062	771	20	novel	novel	ADJ
gs-4062	771	21	mechanisms	mechanism	NOUN
gs-4062	771	22	of	of	ADP
gs-4062	771	23	action	action	NOUN
gs-4062	771	24	,	,	PUNCT
gs-4062	771	25	grapple	grapple	ADJ
gs-4062	771	26	with	with	ADP
gs-4062	771	27	the	the	DET
gs-4062	771	28	stubborn	stubborn	ADJ
gs-4062	771	29	realities	reality	NOUN
gs-4062	771	30	of	of	ADP
gs-4062	771	31	metabolic	metabolic	NOUN
gs-4062	771	32	complications	complication	NOUN
gs-4062	771	33	and	and	CCONJ
gs-4062	771	34	global	global	ADJ
gs-4062	771	35	inequity	inequity	NOUN
gs-4062	771	36	,	,	PUNCT
gs-4062	771	37	and	and	CCONJ
gs-4062	771	38	project	project	VERB
gs-4062	771	39	forward	forward	ADV
gs-4062	771	40	into	into	ADP
gs-4062	771	41	the	the	DET
gs-4062	771	42	nascent	nascent	ADJ
gs-4062	771	43	realm	realm	NOUN
gs-4062	771	44	of	of	ADP
gs-4062	771	45	cure	cure	NOUN
gs-4062	771	46	research	research	NOUN
gs-4062	771	47	.	.	PUNCT
gs-4062	772	1	the	the	DET
gs-4062	772	2	central	central	ADJ
gs-4062	772	3	thesis	thesis	NOUN
gs-4062	772	4	of	of	ADP
gs-4062	772	5	this	this	DET
gs-4062	772	6	discussion	discussion	NOUN
gs-4062	772	7	is	be	AUX
gs-4062	772	8	that	that	SCONJ
gs-4062	772	9	the	the	DET
gs-4062	772	10	field	field	NOUN
gs-4062	772	11	stands	stand	VERB
gs-4062	772	12	at	at	ADP
gs-4062	772	13	a	a	DET
gs-4062	772	14	critical	critical	ADJ
gs-4062	772	15	inflection	inflection	NOUN
gs-4062	772	16	point	point	NOUN
gs-4062	772	17	,	,	PUNCT
gs-4062	772	18	where	where	SCONJ
gs-4062	772	19	the	the	DET
gs-4062	772	20	scientific	scientific	ADJ
gs-4062	772	21	tools	tool	NOUN
gs-4062	772	22	to	to	PART
gs-4062	772	23	end	end	VERB
gs-4062	772	24	the	the	DET
gs-4062	772	25	epidemic	epidemic	NOUN
gs-4062	772	26	are	be	AUX
gs-4062	772	27	within	within	ADP
gs-4062	772	28	grasp	grasp	NOUN
gs-4062	772	29	,	,	PUNCT
gs-4062	772	30	but	but	CCONJ
gs-4062	772	31	their	their	PRON
gs-4062	772	32	ultimate	ultimate	ADJ
gs-4062	772	33	impact	impact	NOUN
gs-4062	772	34	will	will	AUX
gs-4062	772	35	be	be	AUX
gs-4062	772	36	determined	determine	VERB
gs-4062	772	37	not	not	PART
gs-4062	772	38	by	by	ADP
gs-4062	772	39	laboratory	laboratory	NOUN
gs-4062	772	40	prowess	prowess	NOUN
gs-4062	772	41	alone	alone	ADV
gs-4062	772	42	,	,	PUNCT
gs-4062	772	43	but	but	CCONJ
gs-4062	772	44	by	by	ADP
gs-4062	772	45	our	our	PRON
gs-4062	772	46	collective	collective	ADJ
gs-4062	772	47	ability	ability	NOUN
gs-4062	772	48	to	to	PART
gs-4062	772	49	navigate	navigate	VERB
gs-4062	772	50	the	the	DET
gs-4062	772	51	complex	complex	ADJ
gs-4062	772	52	socio	socio	NOUN
gs-4062	772	53	-	-	PUNCT
gs-4062	772	54	economic	economic	ADJ
gs-4062	772	55	,	,	PUNCT
gs-4062	772	56	ethical	ethical	ADJ
gs-4062	772	57	,	,	PUNCT
gs-4062	772	58	and	and	CCONJ
gs-4062	772	59	implementation	implementation	NOUN
gs-4062	772	60	challenges	challenge	NOUN
gs-4062	772	61	that	that	PRON
gs-4062	772	62	accompany	accompany	VERB
gs-4062	772	63	them	they	PRON
gs-4062	772	64	.	.	PUNCT
gs-4062	773	1	the	the	DET
gs-4062	773	2	re	re	NOUN
gs-4062	773	3	-	-	NOUN
gs-4062	773	4	definition	definition	NOUN
gs-4062	773	5	of	of	ADP
gs-4062	773	6	success	success	NOUN
gs-4062	773	7	:	:	PUNCT
gs-4062	773	8	from	from	ADP
gs-4062	773	9	viral	viral	ADJ
gs-4062	773	10	suppression	suppression	NOUN
gs-4062	773	11	to	to	ADP
gs-4062	773	12	holistic	holistic	ADJ
gs-4062	773	13	well	well	ADV
gs-4062	773	14	-	-	PUNCT
gs-4062	773	15	being	be	AUX
gs-4062	773	16	the	the	DET
gs-4062	773	17	most	most	ADV
gs-4062	773	18	profound	profound	ADJ
gs-4062	773	19	implication	implication	NOUN
gs-4062	773	20	of	of	ADP
gs-4062	773	21	the	the	DET
gs-4062	773	22	newest	new	ADJ
gs-4062	773	23	antiretroviral	antiretroviral	ADJ
gs-4062	773	24	agents	agent	NOUN
gs-4062	773	25	is	be	AUX
gs-4062	773	26	the	the	DET
gs-4062	773	27	fundamental	fundamental	ADJ
gs-4062	773	28	redefinition	redefinition	NOUN
gs-4062	773	29	of	of	ADP
gs-4062	773	30	what	what	PRON
gs-4062	773	31	constitutes	constitute	VERB
gs-4062	773	32	successful	successful	ADJ
gs-4062	773	33	hiv	hiv	PROPN
gs-4062	773	34	therapy	therapy	NOUN
gs-4062	773	35	.	.	PUNCT
gs-4062	774	1	for	for	ADP
gs-4062	774	2	two	two	NUM
gs-4062	774	3	decades	decade	NOUN
gs-4062	774	4	,	,	PUNCT
gs-4062	774	5	the	the	DET
gs-4062	774	6	primary	primary	NOUN
gs-4062	774	7	,	,	PUNCT
gs-4062	774	8	and	and	CCONJ
gs-4062	774	9	often	often	ADV
gs-4062	774	10	sole	sole	ADJ
gs-4062	774	11	,	,	PUNCT
gs-4062	774	12	endpoint	endpoint	NOUN
gs-4062	774	13	of	of	ADP
gs-4062	774	14	clinical	clinical	ADJ
gs-4062	774	15	trials	trial	NOUN
gs-4062	774	16	and	and	CCONJ
gs-4062	774	17	clinical	clinical	ADJ
gs-4062	774	18	practice	practice	NOUN
gs-4062	774	19	was	be	AUX
gs-4062	774	20	the	the	DET
gs-4062	774	21	achievement	achievement	NOUN
gs-4062	774	22	and	and	CCONJ
gs-4062	774	23	maintenance	maintenance	NOUN
gs-4062	774	24	of	of	ADP
gs-4062	774	25	an	an	DET
gs-4062	774	26	georgian	georgian	NOUN
gs-4062	774	27	scientists/	scientists/	NUM
gs-4062	774	28	.	.	PUNCT
gs-4062	775	1	7	7	NUM
gs-4062	775	2	n	n	PRON
gs-4062	775	3	3	3	NUM
gs-4062	775	4	,	,	PUNCT
gs-4062	775	5	2025	2025	NUM
gs-4062	775	6	555	555	NUM
gs-4062	775	7	undetectable	undetectable	ADJ
gs-4062	775	8	plasma	plasma	NOUN
gs-4062	775	9	viral	viral	ADJ
gs-4062	775	10	load	load	NOUN
gs-4062	775	11	.	.	PUNCT
gs-4062	776	1	this	this	PRON
gs-4062	776	2	was	be	AUX
gs-4062	776	3	a	a	DET
gs-4062	776	4	necessary	necessary	ADJ
gs-4062	776	5	and	and	CCONJ
gs-4062	776	6	appropriate	appropriate	ADJ
gs-4062	776	7	focus	focus	NOUN
gs-4062	776	8	during	during	ADP
gs-4062	776	9	the	the	DET
gs-4062	776	10	era	era	NOUN
gs-4062	776	11	when	when	SCONJ
gs-4062	776	12	the	the	DET
gs-4062	776	13	alternative	alternative	NOUN
gs-4062	776	14	was	be	AUX
gs-4062	776	15	progressive	progressive	ADJ
gs-4062	776	16	immunodeficiency	immunodeficiency	NOUN
gs-4062	776	17	and	and	CCONJ
gs-4062	776	18	death	death	NOUN
gs-4062	776	19	.	.	PUNCT
gs-4062	777	1	however	however	ADV
gs-4062	777	2	,	,	PUNCT
gs-4062	777	3	the	the	DET
gs-4062	777	4	results	result	NOUN
gs-4062	777	5	from	from	ADP
gs-4062	777	6	studies	study	NOUN
gs-4062	777	7	on	on	ADP
gs-4062	777	8	long	long	ADV
gs-4062	777	9	-	-	PUNCT
gs-4062	777	10	acting	act	VERB
gs-4062	777	11	cabotegravir	cabotegravir	NOUN
gs-4062	777	12	and	and	CCONJ
gs-4062	777	13	rilpivirine	rilpivirine	VERB
gs-4062	777	14	,	,	PUNCT
gs-4062	777	15	and	and	CCONJ
gs-4062	777	16	the	the	DET
gs-4062	777	17	patient	patient	NOUN
gs-4062	777	18	-	-	PUNCT
gs-4062	777	19	reported	report	VERB
gs-4062	777	20	outcomes	outcome	NOUN
gs-4062	777	21	associated	associate	VERB
gs-4062	777	22	with	with	ADP
gs-4062	777	23	them	they	PRON
gs-4062	777	24	,	,	PUNCT
gs-4062	777	25	forcefully	forcefully	ADV
gs-4062	777	26	demonstrate	demonstrate	VERB
gs-4062	777	27	that	that	SCONJ
gs-4062	777	28	virological	virological	ADJ
gs-4062	777	29	suppression	suppression	NOUN
gs-4062	777	30	is	be	AUX
gs-4062	777	31	now	now	ADV
gs-4062	777	32	a	a	DET
gs-4062	777	33	baseline	baseline	ADJ
gs-4062	777	34	expectation	expectation	NOUN
gs-4062	777	35	—	—	PUNCT
gs-4062	777	36	the	the	DET
gs-4062	777	37	entry	entry	NOUN
gs-4062	777	38	ticket	ticket	NOUN
gs-4062	777	39	to	to	ADP
gs-4062	777	40	a	a	DET
gs-4062	777	41	much	much	ADV
gs-4062	777	42	broader	broad	ADJ
gs-4062	777	43	conversation	conversation	NOUN
gs-4062	777	44	about	about	ADP
gs-4062	777	45	quality	quality	NOUN
gs-4062	777	46	of	of	ADP
gs-4062	777	47	life	life	NOUN
gs-4062	777	48	.	.	PUNCT
gs-4062	778	1	the	the	DET
gs-4062	778	2	success	success	NOUN
gs-4062	778	3	of	of	ADP
gs-4062	778	4	a	a	DET
gs-4062	778	5	modern	modern	ADJ
gs-4062	778	6	antiretroviral	antiretroviral	ADJ
gs-4062	778	7	regimen	regiman	NOUN
gs-4062	778	8	is	be	AUX
gs-4062	778	9	now	now	ADV
gs-4062	778	10	equally	equally	ADV
gs-4062	778	11	measured	measure	VERB
gs-4062	778	12	by	by	ADP
gs-4062	778	13	its	its	PRON
gs-4062	778	14	impact	impact	NOUN
gs-4062	778	15	on	on	ADP
gs-4062	778	16	psychological	psychological	ADJ
gs-4062	778	17	well	well	NOUN
gs-4062	778	18	-	-	PUNCT
gs-4062	778	19	being	being	NOUN
gs-4062	778	20	,	,	PUNCT
gs-4062	778	21	its	its	PRON
gs-4062	778	22	ability	ability	NOUN
gs-4062	778	23	to	to	PART
gs-4062	778	24	mitigate	mitigate	VERB
gs-4062	778	25	stigma	stigma	NOUN
gs-4062	778	26	,	,	PUNCT
gs-4062	778	27	and	and	CCONJ
gs-4062	778	28	its	its	PRON
gs-4062	778	29	integration	integration	NOUN
gs-4062	778	30	into	into	ADP
gs-4062	778	31	a	a	DET
gs-4062	778	32	patient	patient	NOUN
gs-4062	778	33	’s	’s	PART
gs-4062	778	34	life	life	NOUN
gs-4062	778	35	with	with	ADP
gs-4062	778	36	minimal	minimal	ADJ
gs-4062	778	37	intrusion	intrusion	NOUN
gs-4062	778	38	.	.	PUNCT
gs-4062	779	1	the	the	DET
gs-4062	779	2	psychological	psychological	ADJ
gs-4062	779	3	liberation	liberation	NOUN
gs-4062	779	4	offered	offer	VERB
gs-4062	779	5	by	by	ADP
gs-4062	779	6	long	long	ADV
gs-4062	779	7	-	-	PUNCT
gs-4062	779	8	acting	act	VERB
gs-4062	779	9	injectable	injectable	ADJ
gs-4062	779	10	therapy	therapy	NOUN
gs-4062	779	11	can	can	AUX
gs-4062	779	12	not	not	PART
gs-4062	779	13	be	be	AUX
gs-4062	779	14	overstated	overstate	VERB
gs-4062	779	15	.	.	PUNCT
gs-4062	780	1	for	for	ADP
gs-4062	780	2	many	many	ADJ
gs-4062	780	3	individuals	individual	NOUN
gs-4062	780	4	,	,	PUNCT
gs-4062	780	5	the	the	DET
gs-4062	780	6	daily	daily	ADJ
gs-4062	780	7	act	act	NOUN
gs-4062	780	8	of	of	ADP
gs-4062	780	9	taking	take	VERB
gs-4062	780	10	an	an	DET
gs-4062	780	11	oral	oral	ADJ
gs-4062	780	12	pill	pill	NOUN
gs-4062	780	13	is	be	AUX
gs-4062	780	14	a	a	DET
gs-4062	780	15	potent	potent	ADJ
gs-4062	780	16	ritual	ritual	NOUN
gs-4062	780	17	that	that	PRON
gs-4062	780	18	reinforces	reinforce	VERB
gs-4062	780	19	their	their	PRON
gs-4062	780	20	identity	identity	NOUN
gs-4062	780	21	as	as	ADP
gs-4062	780	22	a	a	DET
gs-4062	780	23	person	person	NOUN
gs-4062	780	24	living	live	VERB
gs-4062	780	25	with	with	ADP
gs-4062	780	26	a	a	DET
gs-4062	780	27	chronic	chronic	NOUN
gs-4062	780	28	,	,	PUNCT
gs-4062	780	29	stigmatized	stigmatize	VERB
gs-4062	780	30	virus	virus	NOUN
gs-4062	780	31	.	.	PUNCT
gs-4062	781	1	it	it	PRON
gs-4062	781	2	is	be	AUX
gs-4062	781	3	a	a	DET
gs-4062	781	4	private	private	ADJ
gs-4062	781	5	act	act	NOUN
gs-4062	781	6	that	that	PRON
gs-4062	781	7	carries	carry	VERB
gs-4062	781	8	public	public	ADJ
gs-4062	781	9	weight	weight	NOUN
gs-4062	781	10	,	,	PUNCT
gs-4062	781	11	often	often	ADV
gs-4062	781	12	accompanied	accompany	VERB
gs-4062	781	13	by	by	ADP
gs-4062	781	14	fear	fear	NOUN
gs-4062	781	15	of	of	ADP
gs-4062	781	16	discovery	discovery	NOUN
gs-4062	781	17	,	,	PUNCT
gs-4062	781	18	anxiety	anxiety	NOUN
gs-4062	781	19	about	about	ADP
gs-4062	781	20	travel	travel	NOUN
gs-4062	781	21	without	without	ADP
gs-4062	781	22	medications	medication	NOUN
gs-4062	781	23	,	,	PUNCT
gs-4062	781	24	and	and	CCONJ
gs-4062	781	25	the	the	DET
gs-4062	781	26	constant	constant	ADJ
gs-4062	781	27	mental	mental	ADJ
gs-4062	781	28	burden	burden	NOUN
gs-4062	781	29	of	of	ADP
gs-4062	781	30	adherence	adherence	NOUN
gs-4062	781	31	.	.	PUNCT
gs-4062	782	1	the	the	DET
gs-4062	782	2	transition	transition	NOUN
gs-4062	782	3	to	to	ADP
gs-4062	782	4	a	a	DET
gs-4062	782	5	bimonthly	bimonthly	ADJ
gs-4062	782	6	injection	injection	NOUN
gs-4062	782	7	,	,	PUNCT
gs-4062	782	8	administered	administer	VERB
gs-4062	782	9	in	in	ADP
gs-4062	782	10	a	a	DET
gs-4062	782	11	clinical	clinical	ADJ
gs-4062	782	12	setting	setting	NOUN
gs-4062	782	13	,	,	PUNCT
gs-4062	782	14	severs	sever	VERB
gs-4062	782	15	this	this	DET
gs-4062	782	16	chain	chain	NOUN
gs-4062	782	17	.	.	PUNCT
gs-4062	783	1	qualitative	qualitative	ADJ
gs-4062	783	2	data	datum	NOUN
gs-4062	783	3	from	from	ADP
gs-4062	783	4	the	the	DET
gs-4062	783	5	atlas	atlas	PROPN
gs-4062	783	6	and	and	CCONJ
gs-4062	783	7	flair	flair	NOUN
gs-4062	783	8	trials	trial	NOUN
gs-4062	783	9	reveal	reveal	VERB
gs-4062	783	10	powerful	powerful	ADJ
gs-4062	783	11	narratives	narrative	NOUN
gs-4062	783	12	of	of	ADP
gs-4062	783	13	patients	patient	NOUN
gs-4062	783	14	who	who	PRON
gs-4062	783	15	describe	describe	VERB
gs-4062	783	16	feeling	feel	VERB
gs-4062	783	17	"	"	PUNCT
gs-4062	783	18	normal	normal	ADJ
gs-4062	783	19	"	"	PUNCT
gs-4062	783	20	for	for	ADP
gs-4062	783	21	the	the	DET
gs-4062	783	22	first	first	ADJ
gs-4062	783	23	time	time	NOUN
gs-4062	783	24	in	in	ADP
gs-4062	783	25	years	year	NOUN
gs-4062	783	26	,	,	PUNCT
gs-4062	783	27	freed	free	VERB
gs-4062	783	28	from	from	ADP
gs-4062	783	29	the	the	DET
gs-4062	783	30	"	"	PUNCT
gs-4062	783	31	daily	daily	ADJ
gs-4062	783	32	reminder	reminder	NOUN
gs-4062	783	33	"	"	PUNCT
gs-4062	783	34	of	of	ADP
gs-4062	783	35	their	their	PRON
gs-4062	783	36	status	status	NOUN
gs-4062	783	37	.	.	PUNCT
gs-4062	784	1	this	this	PRON
gs-4062	784	2	has	have	VERB
gs-4062	784	3	measurable	measurable	ADJ
gs-4062	784	4	downstream	downstream	ADJ
gs-4062	784	5	effects	effect	NOUN
gs-4062	784	6	on	on	ADP
gs-4062	784	7	mental	mental	ADJ
gs-4062	784	8	health	health	NOUN
gs-4062	784	9	,	,	PUNCT
gs-4062	784	10	reducing	reduce	VERB
gs-4062	784	11	scores	score	NOUN
gs-4062	784	12	for	for	ADP
gs-4062	784	13	anxiety	anxiety	NOUN
gs-4062	784	14	and	and	CCONJ
gs-4062	784	15	depression	depression	NOUN
gs-4062	784	16	and	and	CCONJ
gs-4062	784	17	improving	improve	VERB
gs-4062	784	18	overall	overall	ADJ
gs-4062	784	19	quality	quality	NOUN
gs-4062	784	20	-	-	PUNCT
gs-4062	784	21	of	of	ADP
gs-4062	784	22	-	-	PUNCT
gs-4062	784	23	life	life	NOUN
gs-4062	784	24	metrics	metric	NOUN
gs-4062	784	25	.	.	PUNCT
gs-4062	785	1	therefore	therefore	ADV
gs-4062	785	2	,	,	PUNCT
gs-4062	785	3	the	the	DET
gs-4062	785	4	discussion	discussion	NOUN
gs-4062	785	5	must	must	AUX
gs-4062	785	6	expand	expand	VERB
gs-4062	785	7	to	to	PART
gs-4062	785	8	consider	consider	VERB
gs-4062	785	9	the	the	DET
gs-4062	785	10	mental	mental	ADJ
gs-4062	785	11	health	health	NOUN
gs-4062	785	12	dividend	dividend	NOUN
gs-4062	785	13	of	of	ADP
gs-4062	785	14	these	these	DET
gs-4062	785	15	novel	novel	ADJ
gs-4062	785	16	modalities	modality	NOUN
gs-4062	785	17	.	.	PUNCT
gs-4062	786	1	the	the	DET
gs-4062	786	2	value	value	NOUN
gs-4062	786	3	of	of	ADP
gs-4062	786	4	a	a	DET
gs-4062	786	5	drug	drug	NOUN
gs-4062	786	6	is	be	AUX
gs-4062	786	7	no	no	ADV
gs-4062	786	8	longer	long	ADV
gs-4062	786	9	confined	confine	VERB
gs-4062	786	10	to	to	ADP
gs-4062	786	11	its	its	PRON
gs-4062	786	12	pharmacokinetic	pharmacokinetic	ADJ
gs-4062	786	13	profile	profile	NOUN
gs-4062	786	14	but	but	CCONJ
gs-4062	786	15	is	be	AUX
gs-4062	786	16	also	also	ADV
gs-4062	786	17	measured	measure	VERB
gs-4062	786	18	in	in	ADP
gs-4062	786	19	its	its	PRON
gs-4062	786	20	ability	ability	NOUN
gs-4062	786	21	to	to	PART
gs-4062	786	22	restore	restore	VERB
gs-4062	786	23	a	a	DET
gs-4062	786	24	sense	sense	NOUN
gs-4062	786	25	of	of	ADP
gs-4062	786	26	autonomy	autonomy	NOUN
gs-4062	786	27	and	and	CCONJ
gs-4062	786	28	normalcy	normalcy	NOUN
gs-4062	786	29	.	.	PUNCT
gs-4062	787	1	this	this	DET
gs-4062	787	2	paradigm	paradigm	NOUN
gs-4062	787	3	shift	shift	NOUN
gs-4062	787	4	forces	force	NOUN
gs-4062	787	5	a	a	DET
gs-4062	787	6	re	re	NOUN
gs-4062	787	7	-	-	NOUN
gs-4062	787	8	evaluation	evaluation	NOUN
gs-4062	787	9	of	of	ADP
gs-4062	787	10	cost	cost	NOUN
gs-4062	787	11	-	-	PUNCT
gs-4062	787	12	effectiveness	effectiveness	NOUN
gs-4062	787	13	models	model	NOUN
gs-4062	787	14	.	.	PUNCT
gs-4062	788	1	traditional	traditional	ADJ
gs-4062	788	2	models	model	NOUN
gs-4062	788	3	weigh	weigh	VERB
gs-4062	788	4	the	the	DET
gs-4062	788	5	cost	cost	NOUN
gs-4062	788	6	of	of	ADP
gs-4062	788	7	a	a	DET
gs-4062	788	8	drug	drug	NOUN
gs-4062	788	9	against	against	ADP
gs-4062	788	10	gains	gain	NOUN
gs-4062	788	11	in	in	ADP
gs-4062	788	12	survival	survival	NOUN
gs-4062	788	13	and	and	CCONJ
gs-4062	788	14	reductions	reduction	NOUN
gs-4062	788	15	in	in	ADP
gs-4062	788	16	opportunistic	opportunistic	ADJ
gs-4062	788	17	infections	infection	NOUN
gs-4062	788	18	.	.	PUNCT
gs-4062	789	1	future	future	ADJ
gs-4062	789	2	models	model	NOUN
gs-4062	789	3	must	must	AUX
gs-4062	789	4	incorporate	incorporate	VERB
gs-4062	789	5	the	the	DET
gs-4062	789	6	economic	economic	ADJ
gs-4062	789	7	value	value	NOUN
gs-4062	789	8	of	of	ADP
gs-4062	789	9	improved	improved	ADJ
gs-4062	789	10	mental	mental	ADJ
gs-4062	789	11	health	health	NOUN
gs-4062	789	12	,	,	PUNCT
gs-4062	789	13	reduced	reduced	ADJ
gs-4062	789	14	stigma	stigma	NOUN
gs-4062	789	15	,	,	PUNCT
gs-4062	789	16	and	and	CCONJ
gs-4062	789	17	increased	increase	VERB
gs-4062	789	18	productivity	productivity	NOUN
gs-4062	789	19	—	—	PUNCT
gs-4062	789	20	metrics	metric	NOUN
gs-4062	789	21	that	that	PRON
gs-4062	789	22	are	be	AUX
gs-4062	789	23	inherently	inherently	ADV
gs-4062	789	24	more	more	ADV
gs-4062	789	25	difficult	difficult	ADJ
gs-4062	789	26	to	to	PART
gs-4062	789	27	quantify	quantify	VERB
gs-4062	789	28	but	but	CCONJ
gs-4062	789	29	are	be	AUX
gs-4062	789	30	no	no	PRON
gs-4062	789	31	less	less	ADV
gs-4062	789	32	real	real	ADJ
gs-4062	789	33	to	to	ADP
gs-4062	789	34	the	the	DET
gs-4062	789	35	individual	individual	NOUN
gs-4062	789	36	living	live	VERB
gs-4062	789	37	with	with	ADP
gs-4062	789	38	hiv	hiv	PROPN
gs-4062	789	39	.	.	PUNCT
gs-4062	790	1	the	the	DET
gs-4062	790	2	intricate	intricate	ADJ
gs-4062	790	3	narrative	narrative	NOUN
gs-4062	790	4	of	of	ADP
gs-4062	790	5	instis	instis	NOUN
gs-4062	790	6	:	:	PUNCT
gs-4062	790	7	weaving	weaving	NOUN
gs-4062	790	8	efficacy	efficacy	NOUN
gs-4062	790	9	,	,	PUNCT
gs-4062	790	10	weight	weight	NOUN
gs-4062	790	11	gain	gain	NOUN
gs-4062	790	12	,	,	PUNCT
gs-4062	790	13	and	and	CCONJ
gs-4062	790	14	long	long	ADJ
gs-4062	790	15	-	-	PUNCT
gs-4062	790	16	term	term	NOUN
gs-4062	790	17	management	management	NOUN
gs-4062	790	18	the	the	DET
gs-4062	790	19	dominance	dominance	NOUN
gs-4062	790	20	of	of	ADP
gs-4062	790	21	second	second	ADJ
gs-4062	790	22	-	-	PUNCT
gs-4062	790	23	generation	generation	NOUN
gs-4062	790	24	integrase	integrase	NOUN
gs-4062	790	25	strand	strand	NOUN
gs-4062	790	26	transfer	transfer	NOUN
gs-4062	790	27	inhibitors	inhibitor	NOUN
gs-4062	790	28	,	,	PUNCT
gs-4062	790	29	specifically	specifically	ADV
gs-4062	790	30	dolutegravir	dolutegravir	PROPN
gs-4062	790	31	and	and	CCONJ
gs-4062	790	32	bictegravir	bictegravir	PROPN
gs-4062	790	33	,	,	PUNCT
gs-4062	790	34	as	as	SCONJ
gs-4062	790	35	the	the	DET
gs-4062	790	36	cornerstone	cornerstone	NOUN
gs-4062	790	37	of	of	ADP
gs-4062	790	38	global	global	ADJ
gs-4062	790	39	first	first	ADJ
gs-4062	790	40	-	-	PUNCT
gs-4062	790	41	line	line	NOUN
gs-4062	790	42	therapy	therapy	NOUN
gs-4062	790	43	is	be	AUX
gs-4062	790	44	a	a	DET
gs-4062	790	45	testament	testament	NOUN
gs-4062	790	46	to	to	ADP
gs-4062	790	47	their	their	PRON
gs-4062	790	48	unrivalled	unrivalled	ADJ
gs-4062	790	49	efficacy	efficacy	NOUN
gs-4062	790	50	and	and	CCONJ
gs-4062	790	51	tolerability	tolerability	NOUN
gs-4062	790	52	compared	compare	VERB
gs-4062	790	53	to	to	ADP
gs-4062	790	54	previous	previous	ADJ
gs-4062	790	55	standards	standard	NOUN
gs-4062	790	56	.	.	PUNCT
gs-4062	791	1	however	however	ADV
gs-4062	791	2	,	,	PUNCT
gs-4062	791	3	the	the	DET
gs-4062	791	4	emergence	emergence	NOUN
gs-4062	791	5	of	of	ADP
gs-4062	791	6	weight	weight	NOUN
gs-4062	791	7	gain	gain	NOUN
gs-4062	791	8	as	as	ADP
gs-4062	791	9	a	a	DET
gs-4062	791	10	significant	significant	ADJ
gs-4062	791	11	class	class	NOUN
gs-4062	791	12	effect	effect	NOUN
gs-4062	791	13	has	have	AUX
gs-4062	791	14	introduced	introduce	VERB
gs-4062	791	15	a	a	DET
gs-4062	791	16	complex	complex	ADJ
gs-4062	791	17	and	and	CCONJ
gs-4062	791	18	necessary	necessary	ADJ
gs-4062	791	19	nuance	nuance	NOUN
gs-4062	791	20	into	into	ADP
gs-4062	791	21	this	this	DET
gs-4062	791	22	narrative	narrative	NOUN
gs-4062	791	23	.	.	PUNCT
gs-4062	792	1	the	the	DET
gs-4062	792	2	discussion	discussion	NOUN
gs-4062	792	3	surrounding	surround	VERB
gs-4062	792	4	this	this	DET
gs-4062	792	5	phenomenon	phenomenon	NOUN
gs-4062	792	6	must	must	AUX
gs-4062	792	7	avoid	avoid	VERB
gs-4062	792	8	alarmism	alarmism	NOUN
gs-4062	792	9	while	while	SCONJ
gs-4062	792	10	simultaneously	simultaneously	ADV
gs-4062	792	11	taking	take	VERB
gs-4062	792	12	it	it	PRON
gs-4062	792	13	seriously	seriously	ADV
gs-4062	792	14	as	as	ADP
gs-4062	792	15	a	a	DET
gs-4062	792	16	legitimate	legitimate	ADJ
gs-4062	792	17	clinical	clinical	ADJ
gs-4062	792	18	challenge	challenge	NOUN
gs-4062	792	19	.	.	PUNCT
gs-4062	793	1	the	the	DET
gs-4062	793	2	data	data	NOUN
gs-4062	793	3	is	be	AUX
gs-4062	793	4	now	now	ADV
gs-4062	793	5	conclusive	conclusive	ADJ
gs-4062	793	6	that	that	SCONJ
gs-4062	793	7	this	this	PRON
gs-4062	793	8	is	be	AUX
gs-4062	793	9	a	a	DET
gs-4062	793	10	real	real	ADJ
gs-4062	793	11	effect	effect	NOUN
gs-4062	793	12	,	,	PUNCT
gs-4062	793	13	particularly	particularly	ADV
gs-4062	793	14	pronounced	pronounce	VERB
gs-4062	793	15	in	in	ADP
gs-4062	793	16	women	woman	NOUN
gs-4062	793	17	of	of	ADP
gs-4062	793	18	african	african	ADJ
gs-4062	793	19	descent	descent	NOUN
gs-4062	793	20	,	,	PUNCT
gs-4062	793	21	and	and	CCONJ
gs-4062	793	22	when	when	SCONJ
gs-4062	793	23	instis	instis	PROPN
gs-4062	793	24	are	be	AUX
gs-4062	793	25	combined	combine	VERB
gs-4062	793	26	with	with	ADP
gs-4062	793	27	tenofovir	tenofovir	PROPN
gs-4062	793	28	alafenamide	alafenamide	PROPN
gs-4062	793	29	.	.	PUNCT
gs-4062	794	1	the	the	DET
gs-4062	794	2	key	key	NOUN
gs-4062	794	3	to	to	ADP
gs-4062	794	4	a	a	DET
gs-4062	794	5	rational	rational	ADJ
gs-4062	794	6	discussion	discussion	NOUN
gs-4062	794	7	lies	lie	VERB
gs-4062	794	8	in	in	ADP
gs-4062	794	9	moving	move	VERB
gs-4062	794	10	from	from	ADP
gs-4062	794	11	establishing	establish	VERB
gs-4062	794	12	association	association	NOUN
gs-4062	794	13	to	to	ADP
gs-4062	794	14	understanding	understanding	NOUN
gs-4062	794	15	mechanism	mechanism	NOUN
gs-4062	794	16	and	and	CCONJ
gs-4062	794	17	,	,	PUNCT
gs-4062	794	18	ultimately	ultimately	ADV
gs-4062	794	19	,	,	PUNCT
gs-4062	794	20	to	to	ADP
gs-4062	794	21	developing	develop	VERB
gs-4062	794	22	management	management	NOUN
gs-4062	794	23	strategies	strategy	NOUN
gs-4062	794	24	.	.	PUNCT
gs-4062	795	1	the	the	DET
gs-4062	795	2	leading	lead	VERB
gs-4062	795	3	hypotheses	hypothesis	NOUN
gs-4062	795	4	for	for	ADP
gs-4062	795	5	the	the	DET
gs-4062	795	6	mechanism	mechanism	NOUN
gs-4062	795	7	of	of	ADP
gs-4062	795	8	insti	insti	NOUN
gs-4062	795	9	-	-	PUNCT
gs-4062	795	10	associated	associate	VERB
gs-4062	795	11	weight	weight	NOUN
gs-4062	795	12	gain	gain	NOUN
gs-4062	795	13	are	be	AUX
gs-4062	795	14	multifaceted	multifaceted	ADJ
gs-4062	795	15	.	.	PUNCT
gs-4062	796	1	the	the	DET
gs-4062	796	2	most	most	ADV
gs-4062	796	3	compelling	compelling	ADJ
gs-4062	796	4	theory	theory	NOUN
gs-4062	796	5	involves	involve	VERB
gs-4062	796	6	off	off	ADP
gs-4062	796	7	-	-	PUNCT
gs-4062	796	8	target	target	NOUN
gs-4062	796	9	effects	effect	NOUN
gs-4062	796	10	on	on	ADP
gs-4062	796	11	melanocortin-4	melanocortin-4	NUM
gs-4062	796	12	receptors	receptor	NOUN
gs-4062	796	13	(	(	PUNCT
gs-4062	796	14	mc4r	mc4r	NOUN
gs-4062	796	15	)	)	PUNCT
gs-4062	796	16	in	in	ADP
gs-4062	796	17	the	the	DET
gs-4062	796	18	hypothalamus	hypothalamus	PROPN
gs-4062	796	19	,	,	PUNCT
gs-4062	796	20	a	a	DET
gs-4062	796	21	key	key	ADJ
gs-4062	796	22	center	center	NOUN
gs-4062	796	23	for	for	ADP
gs-4062	796	24	regulating	regulate	VERB
gs-4062	796	25	appetite	appetite	NOUN
gs-4062	796	26	and	and	CCONJ
gs-4062	796	27	energy	energy	NOUN
gs-4062	796	28	expenditure	expenditure	NOUN
gs-4062	796	29	.	.	PUNCT
gs-4062	797	1	it	it	PRON
gs-4062	797	2	is	be	AUX
gs-4062	797	3	postulated	postulate	VERB
gs-4062	797	4	that	that	SCONJ
gs-4062	797	5	instis	instis	PROPN
gs-4062	797	6	may	may	AUX
gs-4062	797	7	inadvertently	inadvertently	ADV
gs-4062	797	8	antagonize	antagonize	VERB
gs-4062	797	9	this	this	DET
gs-4062	797	10	receptor	receptor	NOUN
gs-4062	797	11	,	,	PUNCT
gs-4062	797	12	leading	lead	VERB
gs-4062	797	13	to	to	ADP
gs-4062	797	14	increased	increase	VERB
gs-4062	797	15	appetite	appetite	NOUN
gs-4062	797	16	and	and	CCONJ
gs-4062	797	17	reduced	reduced	ADJ
gs-4062	797	18	satiety	satiety	NOUN
gs-4062	797	19	.	.	PUNCT
gs-4062	798	1	other	other	ADJ
gs-4062	798	2	theories	theory	NOUN
gs-4062	798	3	suggest	suggest	VERB
gs-4062	798	4	a	a	DET
gs-4062	798	5	direct	direct	ADJ
gs-4062	798	6	effect	effect	NOUN
gs-4062	798	7	on	on	ADP
gs-4062	798	8	adipogenesis	adipogenesis	NOUN
gs-4062	798	9	—	—	PUNCT
gs-4062	798	10	the	the	DET
gs-4062	798	11	differentiation	differentiation	NOUN
gs-4062	798	12	of	of	ADP
gs-4062	798	13	preadipocytes	preadipocyte	NOUN
gs-4062	798	14	into	into	ADP
gs-4062	798	15	mature	mature	ADJ
gs-4062	798	16	fat	fat	ADJ
gs-4062	798	17	cells	cell	NOUN
gs-4062	798	18	—	—	PUNCT
gs-4062	798	19	particularly	particularly	ADV
gs-4062	798	20	in	in	ADP
gs-4062	798	21	the	the	DET
gs-4062	798	22	visceral	visceral	ADJ
gs-4062	798	23	compartment	compartment	NOUN
gs-4062	798	24	.	.	PUNCT
gs-4062	799	1	alternatively	alternatively	ADV
gs-4062	799	2	,	,	PUNCT
gs-4062	799	3	some	some	DET
gs-4062	799	4	researchers	researcher	NOUN
gs-4062	799	5	propose	propose	VERB
gs-4062	799	6	an	an	DET
gs-4062	799	7	"	"	PUNCT
gs-4062	799	8	indirect	indirect	ADJ
gs-4062	799	9	"	"	PUNCT
gs-4062	799	10	hypothesis	hypothesis	NOUN
gs-4062	799	11	:	:	PUNCT
gs-4062	799	12	that	that	SCONJ
gs-4062	799	13	the	the	DET
gs-4062	799	14	superior	superior	ADJ
gs-4062	799	15	metabolic	metabolic	PROPN
gs-4062	799	16	health	health	NOUN
gs-4062	799	17	,	,	PUNCT
gs-4062	799	18	reduced	reduce	VERB
gs-4062	799	19	inflammation	inflammation	NOUN
gs-4062	799	20	,	,	PUNCT
gs-4062	799	21	and	and	CCONJ
gs-4062	799	22	overall	overall	ADJ
gs-4062	799	23	sense	sense	NOUN
gs-4062	799	24	of	of	ADP
gs-4062	799	25	well	well	ADV
gs-4062	799	26	-	-	PUNCT
gs-4062	799	27	being	be	AUX
gs-4062	799	28	achieved	achieve	VERB
gs-4062	799	29	with	with	ADP
gs-4062	799	30	these	these	DET
gs-4062	799	31	highly	highly	ADV
gs-4062	799	32	effective	effective	ADJ
gs-4062	799	33	regimens	regimen	NOUN
gs-4062	799	34	naturally	naturally	ADV
gs-4062	799	35	lead	lead	VERB
gs-4062	799	36	to	to	ADP
gs-4062	799	37	improved	improved	ADJ
gs-4062	799	38	appetite	appetite	NOUN
gs-4062	799	39	and	and	CCONJ
gs-4062	799	40	weight	weight	NOUN
gs-4062	799	41	gain	gain	NOUN
gs-4062	799	42	,	,	PUNCT
gs-4062	799	43	a	a	DET
gs-4062	799	44	so	so	ADV
gs-4062	799	45	-	-	PUNCT
gs-4062	799	46	called	call	VERB
gs-4062	799	47	"	"	PUNCT
gs-4062	799	48	return	return	VERB
gs-4062	799	49	-	-	PUNCT
gs-4062	799	50	to	to	ADP
gs-4062	799	51	-	-	PUNCT
gs-4062	799	52	health	health	NOUN
gs-4062	799	53	"	"	PUNCT
gs-4062	799	54	effect	effect	NOUN
gs-4062	799	55	.	.	PUNCT
gs-4062	800	1	however	however	ADV
gs-4062	800	2	,	,	PUNCT
gs-4062	800	3	georgian	georgian	PROPN
gs-4062	800	4	scientists/	scientists/	NUM
gs-4062	800	5	.	.	PUNCT
gs-4062	801	1	7	7	NUM
gs-4062	801	2	n	n	PRON
gs-4062	801	3	3	3	NUM
gs-4062	801	4	,	,	PUNCT
gs-4062	801	5	2025	2025	NUM
gs-4062	801	6	556	556	NUM
gs-4062	801	7	the	the	DET
gs-4062	801	8	specific	specific	ADJ
gs-4062	801	9	patterning	patterning	NOUN
gs-4062	801	10	of	of	ADP
gs-4062	801	11	the	the	DET
gs-4062	801	12	weight	weight	NOUN
gs-4062	801	13	gain	gain	NOUN
gs-4062	801	14	and	and	CCONJ
gs-4062	801	15	its	its	PRON
gs-4062	801	16	disproportional	disproportional	ADJ
gs-4062	801	17	effect	effect	NOUN
gs-4062	801	18	on	on	ADP
gs-4062	801	19	certain	certain	ADJ
gs-4062	801	20	populations	population	NOUN
gs-4062	801	21	suggest	suggest	VERB
gs-4062	801	22	a	a	DET
gs-4062	801	23	more	more	ADV
gs-4062	801	24	direct	direct	ADJ
gs-4062	801	25	pharmacological	pharmacological	ADJ
gs-4062	801	26	effect	effect	NOUN
gs-4062	801	27	is	be	AUX
gs-4062	801	28	at	at	ADP
gs-4062	801	29	play	play	NOUN
gs-4062	801	30	.	.	PUNCT
gs-4062	802	1	for	for	ADP
gs-4062	802	2	the	the	DET
gs-4062	802	3	clinician	clinician	NOUN
gs-4062	802	4	,	,	PUNCT
gs-4062	802	5	this	this	DET
gs-4062	802	6	discussion	discussion	NOUN
gs-4062	802	7	moves	move	VERB
gs-4062	802	8	from	from	ADP
gs-4062	802	9	the	the	DET
gs-4062	802	10	theoretical	theoretical	NOUN
gs-4062	802	11	to	to	ADP
gs-4062	802	12	the	the	DET
gs-4062	802	13	practical	practical	ADJ
gs-4062	802	14	.	.	PUNCT
gs-4062	803	1	how	how	SCONJ
gs-4062	803	2	should	should	AUX
gs-4062	803	3	this	this	DET
gs-4062	803	4	knowledge	knowledge	NOUN
gs-4062	803	5	inform	inform	VERB
gs-4062	803	6	practice	practice	NOUN
gs-4062	803	7	?	?	PUNCT
gs-4062	804	1	first	first	ADV
gs-4062	804	2	,	,	PUNCT
gs-4062	804	3	it	it	PRON
gs-4062	804	4	necessitates	necessitate	VERB
gs-4062	804	5	a	a	DET
gs-4062	804	6	pre	pre	ADJ
gs-4062	804	7	-	-	NOUN
gs-4062	804	8	therapy	therapy	ADJ
gs-4062	804	9	conversation	conversation	NOUN
gs-4062	804	10	that	that	PRON
gs-4062	804	11	is	be	AUX
gs-4062	804	12	now	now	ADV
gs-4062	804	13	standard	standard	ADJ
gs-4062	804	14	for	for	ADP
gs-4062	804	15	any	any	DET
gs-4062	804	16	drug	drug	NOUN
gs-4062	804	17	with	with	ADP
gs-4062	804	18	a	a	DET
gs-4062	804	19	significant	significant	ADJ
gs-4062	804	20	side	side	NOUN
gs-4062	804	21	effect	effect	NOUN
gs-4062	804	22	profile	profile	NOUN
gs-4062	804	23	.	.	PUNCT
gs-4062	805	1	patients	patient	NOUN
gs-4062	805	2	,	,	PUNCT
gs-4062	805	3	particularly	particularly	ADV
gs-4062	805	4	women	woman	NOUN
gs-4062	805	5	,	,	PUNCT
gs-4062	805	6	should	should	AUX
gs-4062	805	7	be	be	AUX
gs-4062	805	8	counseled	counsel	VERB
gs-4062	805	9	about	about	ADP
gs-4062	805	10	the	the	DET
gs-4062	805	11	potential	potential	NOUN
gs-4062	805	12	for	for	ADP
gs-4062	805	13	weight	weight	NOUN
gs-4062	805	14	gain	gain	NOUN
gs-4062	805	15	before	before	ADP
gs-4062	805	16	initiating	initiate	VERB
gs-4062	805	17	an	an	DET
gs-4062	805	18	insti	insti	NOUN
gs-4062	805	19	-	-	PUNCT
gs-4062	805	20	based	base	VERB
gs-4062	805	21	regimen	regiman	NOUN
gs-4062	805	22	.	.	PUNCT
gs-4062	806	1	this	this	PRON
gs-4062	806	2	manages	manage	VERB
gs-4062	806	3	expectations	expectation	NOUN
gs-4062	806	4	and	and	CCONJ
gs-4062	806	5	allows	allow	VERB
gs-4062	806	6	for	for	ADP
gs-4062	806	7	shared	shared	ADJ
gs-4062	806	8	decision	decision	NOUN
gs-4062	806	9	-	-	PUNCT
gs-4062	806	10	making	making	NOUN
gs-4062	806	11	.	.	PUNCT
gs-4062	807	1	second	second	ADJ
gs-4062	807	2	,	,	PUNCT
gs-4062	807	3	it	it	PRON
gs-4062	807	4	mandates	mandate	VERB
gs-4062	807	5	proactive	proactive	ADJ
gs-4062	807	6	monitoring	monitoring	NOUN
gs-4062	807	7	.	.	PUNCT
gs-4062	808	1	baseline	baseline	PROPN
gs-4062	808	2	weight	weight	PROPN
gs-4062	808	3	,	,	PUNCT
gs-4062	808	4	waist	waist	NOUN
gs-4062	808	5	circumference	circumference	NOUN
gs-4062	808	6	,	,	PUNCT
gs-4062	808	7	and	and	CCONJ
gs-4062	808	8	metabolic	metabolic	NOUN
gs-4062	808	9	parameters	parameter	NOUN
gs-4062	808	10	(	(	PUNCT
gs-4062	808	11	lipids	lipids	PROPN
gs-4062	808	12	,	,	PUNCT
gs-4062	808	13	hba1c	hba1c	PROPN
gs-4062	808	14	)	)	PUNCT
gs-4062	808	15	should	should	AUX
gs-4062	808	16	be	be	AUX
gs-4062	808	17	recorded	record	VERB
gs-4062	808	18	.	.	PUNCT
gs-4062	809	1	regular	regular	ADJ
gs-4062	809	2	follow	follow	NOUN
gs-4062	809	3	-	-	PUNCT
gs-4062	809	4	up	up	NOUN
gs-4062	809	5	allows	allow	VERB
gs-4062	809	6	for	for	ADP
gs-4062	809	7	early	early	ADJ
gs-4062	809	8	identification	identification	NOUN
gs-4062	809	9	of	of	ADP
gs-4062	809	10	problematic	problematic	ADJ
gs-4062	809	11	gain	gain	NOUN
gs-4062	809	12	.	.	PUNCT
gs-4062	810	1	third	third	ADJ
gs-4062	810	2	,	,	PUNCT
gs-4062	810	3	and	and	CCONJ
gs-4062	810	4	most	most	ADV
gs-4062	810	5	importantly	importantly	ADV
gs-4062	810	6	,	,	PUNCT
gs-4062	810	7	it	it	PRON
gs-4062	810	8	requires	require	VERB
gs-4062	810	9	a	a	DET
gs-4062	810	10	structured	structured	ADJ
gs-4062	810	11	management	management	NOUN
gs-4062	810	12	approach	approach	NOUN
gs-4062	810	13	.	.	PUNCT
gs-4062	811	1	the	the	DET
gs-4062	811	2	first	first	ADJ
gs-4062	811	3	step	step	NOUN
gs-4062	811	4	is	be	AUX
gs-4062	811	5	always	always	ADV
gs-4062	811	6	lifestyle	lifestyle	NOUN
gs-4062	811	7	intervention	intervention	NOUN
gs-4062	811	8	:	:	PUNCT
gs-4062	811	9	nutritional	nutritional	ADJ
gs-4062	811	10	counseling	counseling	NOUN
gs-4062	811	11	and	and	CCONJ
gs-4062	811	12	encouragement	encouragement	NOUN
gs-4062	811	13	of	of	ADP
gs-4062	811	14	physical	physical	ADJ
gs-4062	811	15	activity	activity	NOUN
gs-4062	811	16	.	.	PUNCT
gs-4062	812	1	for	for	ADP
gs-4062	812	2	patients	patient	NOUN
gs-4062	812	3	with	with	ADP
gs-4062	812	4	significant	significant	ADJ
gs-4062	812	5	gain	gain	NOUN
gs-4062	812	6	that	that	PRON
gs-4062	812	7	impacts	impact	VERB
gs-4062	812	8	their	their	PRON
gs-4062	812	9	health	health	NOUN
gs-4062	812	10	or	or	CCONJ
gs-4062	812	11	well	well	ADV
gs-4062	812	12	-	-	PUNCT
gs-4062	812	13	being	being	NOUN
gs-4062	812	14	,	,	PUNCT
gs-4062	812	15	the	the	DET
gs-4062	812	16	discussion	discussion	NOUN
gs-4062	812	17	must	must	AUX
gs-4062	812	18	turn	turn	VERB
gs-4062	812	19	to	to	ADP
gs-4062	812	20	switching	switch	VERB
gs-4062	812	21	strategies	strategy	NOUN
gs-4062	812	22	.	.	PUNCT
gs-4062	813	1	data	datum	NOUN
gs-4062	813	2	shows	show	VERB
gs-4062	813	3	that	that	SCONJ
gs-4062	813	4	switching	switch	VERB
gs-4062	813	5	from	from	ADP
gs-4062	813	6	an	an	DET
gs-4062	813	7	insti	insti	NOUN
gs-4062	813	8	to	to	ADP
gs-4062	813	9	a	a	DET
gs-4062	813	10	protease	protease	NOUN
gs-4062	813	11	inhibitor	inhibitor	NOUN
gs-4062	813	12	like	like	ADP
gs-4062	813	13	darunavir	darunavir	PROPN
gs-4062	813	14	or	or	CCONJ
gs-4062	813	15	a	a	DET
gs-4062	813	16	newer	new	ADJ
gs-4062	813	17	nnrti	nnrti	NOUN
gs-4062	813	18	like	like	ADP
gs-4062	813	19	doravirine	doravirine	PROPN
gs-4062	813	20	can	can	AUX
gs-4062	813	21	lead	lead	VERB
gs-4062	813	22	to	to	ADP
gs-4062	813	23	weight	weight	NOUN
gs-4062	813	24	stabilization	stabilization	NOUN
gs-4062	813	25	or	or	CCONJ
gs-4062	813	26	modest	modest	ADJ
gs-4062	813	27	loss	loss	NOUN
gs-4062	813	28	.	.	PUNCT
gs-4062	814	1	however	however	ADV
gs-4062	814	2	,	,	PUNCT
gs-4062	814	3	this	this	DET
gs-4062	814	4	decision	decision	NOUN
gs-4062	814	5	must	must	AUX
gs-4062	814	6	be	be	AUX
gs-4062	814	7	balanced	balance	VERB
gs-4062	814	8	against	against	ADP
gs-4062	814	9	the	the	DET
gs-4062	814	10	superior	superior	ADJ
gs-4062	814	11	efficacy	efficacy	NOUN
gs-4062	814	12	and	and	CCONJ
gs-4062	814	13	higher	high	ADJ
gs-4062	814	14	genetic	genetic	ADJ
gs-4062	814	15	barrier	barrier	NOUN
gs-4062	814	16	to	to	ADP
gs-4062	814	17	resistance	resistance	NOUN
gs-4062	814	18	of	of	ADP
gs-4062	814	19	the	the	DET
gs-4062	814	20	insti	insti	NOUN
gs-4062	814	21	.	.	PUNCT
gs-4062	815	1	for	for	ADP
gs-4062	815	2	most	most	ADJ
gs-4062	815	3	patients	patient	NOUN
gs-4062	815	4	,	,	PUNCT
gs-4062	815	5	the	the	DET
gs-4062	815	6	benefits	benefit	NOUN
gs-4062	815	7	of	of	ADP
gs-4062	815	8	dolutegravir	dolutegravir	NOUN
gs-4062	815	9	or	or	CCONJ
gs-4062	815	10	bictegravir	bictegravir	PROPN
gs-4062	815	11	will	will	AUX
gs-4062	815	12	far	far	ADV
gs-4062	815	13	outweigh	outweigh	VERB
gs-4062	815	14	the	the	DET
gs-4062	815	15	concerns	concern	NOUN
gs-4062	815	16	about	about	ADP
gs-4062	815	17	weight	weight	NOUN
gs-4062	815	18	gain	gain	NOUN
gs-4062	815	19	,	,	PUNCT
gs-4062	815	20	and	and	CCONJ
gs-4062	815	21	the	the	DET
gs-4062	815	22	goal	goal	NOUN
gs-4062	815	23	becomes	become	VERB
gs-4062	815	24	management	management	NOUN
gs-4062	815	25	rather	rather	ADV
gs-4062	815	26	than	than	ADP
gs-4062	815	27	avoidance	avoidance	NOUN
gs-4062	815	28	.	.	PUNCT
gs-4062	816	1	this	this	DET
gs-4062	816	2	nuanced	nuanced	ADJ
gs-4062	816	3	,	,	PUNCT
gs-4062	816	4	patientcentered	patientcentere	VERB
gs-4062	816	5	approach	approach	NOUN
gs-4062	816	6	exemplifies	exemplify	VERB
gs-4062	816	7	the	the	DET
gs-4062	816	8	evolution	evolution	NOUN
gs-4062	816	9	of	of	ADP
gs-4062	816	10	hiv	hiv	PROPN
gs-4062	816	11	medicine	medicine	NOUN
gs-4062	816	12	into	into	ADP
gs-4062	816	13	a	a	DET
gs-4062	816	14	sophisticated	sophisticated	ADJ
gs-4062	816	15	practice	practice	NOUN
gs-4062	816	16	of	of	ADP
gs-4062	816	17	personalized	personalized	ADJ
gs-4062	816	18	care	care	NOUN
gs-4062	816	19	.	.	PUNCT
gs-4062	817	1	the	the	DET
gs-4062	817	2	logistics	logistic	NOUN
gs-4062	817	3	of	of	ADP
gs-4062	817	4	liberation	liberation	NOUN
gs-4062	817	5	:	:	PUNCT
gs-4062	817	6	implementing	implement	VERB
gs-4062	817	7	long	long	ADV
gs-4062	817	8	-	-	PUNCT
gs-4062	817	9	acting	act	VERB
gs-4062	817	10	therapy	therapy	NOUN
gs-4062	817	11	in	in	ADP
gs-4062	817	12	the	the	DET
gs-4062	817	13	real	real	ADJ
gs-4062	817	14	world	world	NOUN
gs-4062	817	15	the	the	DET
gs-4062	817	16	clinical	clinical	ADJ
gs-4062	817	17	trial	trial	NOUN
gs-4062	817	18	results	result	NOUN
gs-4062	817	19	for	for	ADP
gs-4062	817	20	long	long	ADV
gs-4062	817	21	-	-	PUNCT
gs-4062	817	22	acting	act	VERB
gs-4062	817	23	cabotegravir	cabotegravir	NOUN
gs-4062	817	24	and	and	CCONJ
gs-4062	817	25	rilpivirine	rilpivirine	VERB
gs-4062	817	26	are	be	AUX
gs-4062	817	27	impressive	impressive	ADJ
gs-4062	817	28	,	,	PUNCT
gs-4062	817	29	but	but	CCONJ
gs-4062	817	30	their	their	PRON
gs-4062	817	31	translation	translation	NOUN
gs-4062	817	32	into	into	ADP
gs-4062	817	33	real	real	ADJ
gs-4062	817	34	-	-	PUNCT
gs-4062	817	35	world	world	NOUN
gs-4062	817	36	clinical	clinical	ADJ
gs-4062	817	37	practice	practice	NOUN
gs-4062	817	38	presents	present	VERB
gs-4062	817	39	a	a	DET
gs-4062	817	40	set	set	NOUN
gs-4062	817	41	of	of	ADP
gs-4062	817	42	formidable	formidable	ADJ
gs-4062	817	43	logistical	logistical	ADJ
gs-4062	817	44	and	and	CCONJ
gs-4062	817	45	systemic	systemic	ADJ
gs-4062	817	46	challenges	challenge	NOUN
gs-4062	817	47	that	that	PRON
gs-4062	817	48	must	must	AUX
gs-4062	817	49	be	be	AUX
gs-4062	817	50	thoroughly	thoroughly	ADV
gs-4062	817	51	discussed	discuss	VERB
gs-4062	817	52	.	.	PUNCT
gs-4062	818	1	the	the	DET
gs-4062	818	2	administration	administration	NOUN
gs-4062	818	3	of	of	ADP
gs-4062	818	4	long	long	ADV
gs-4062	818	5	-	-	PUNCT
gs-4062	818	6	acting	act	VERB
gs-4062	818	7	injectable	injectable	ADJ
gs-4062	818	8	art	art	NOUN
gs-4062	818	9	is	be	AUX
gs-4062	818	10	not	not	PART
gs-4062	818	11	simply	simply	ADV
gs-4062	818	12	a	a	DET
gs-4062	818	13	switch	switch	NOUN
gs-4062	818	14	in	in	ADP
gs-4062	818	15	formulation	formulation	NOUN
gs-4062	818	16	;	;	PUNCT
gs-4062	818	17	it	it	PRON
gs-4062	818	18	represents	represent	VERB
gs-4062	818	19	a	a	DET
gs-4062	818	20	fundamental	fundamental	ADJ
gs-4062	818	21	restructuring	restructuring	NOUN
gs-4062	818	22	of	of	ADP
gs-4062	818	23	the	the	DET
gs-4062	818	24	clinical	clinical	ADJ
gs-4062	818	25	encounter	encounter	NOUN
gs-4062	818	26	and	and	CCONJ
gs-4062	818	27	the	the	DET
gs-4062	818	28	healthcare	healthcare	NOUN
gs-4062	818	29	system	system	NOUN
gs-4062	818	30	that	that	PRON
gs-4062	818	31	supports	support	VERB
gs-4062	818	32	it	it	PRON
gs-4062	818	33	.	.	PUNCT
gs-4062	819	1	the	the	DET
gs-4062	819	2	traditional	traditional	ADJ
gs-4062	819	3	model	model	NOUN
gs-4062	819	4	of	of	ADP
gs-4062	819	5	hiv	hiv	PROPN
gs-4062	819	6	care	care	NOUN
gs-4062	819	7	is	be	AUX
gs-4062	819	8	built	build	VERB
gs-4062	819	9	around	around	ADP
gs-4062	819	10	periodic	periodic	ADJ
gs-4062	819	11	clinic	clinic	NOUN
gs-4062	819	12	visits	visit	NOUN
gs-4062	819	13	(	(	PUNCT
gs-4062	819	14	e.g.	e.g.	ADV
gs-4062	819	15	,	,	PUNCT
gs-4062	819	16	every	every	DET
gs-4062	819	17	3	3	NUM
gs-4062	819	18	-	-	SYM
gs-4062	819	19	6	6	NUM
gs-4062	819	20	months	month	NOUN
gs-4062	819	21	)	)	PUNCT
gs-4062	819	22	where	where	SCONJ
gs-4062	819	23	prescriptions	prescription	NOUN
gs-4062	819	24	for	for	ADP
gs-4062	819	25	oral	oral	ADJ
gs-4062	819	26	medications	medication	NOUN
gs-4062	819	27	are	be	AUX
gs-4062	819	28	renewed	renew	VERB
gs-4062	819	29	,	,	PUNCT
gs-4062	819	30	and	and	CCONJ
gs-4062	819	31	adherence	adherence	NOUN
gs-4062	819	32	is	be	AUX
gs-4062	819	33	assessed	assess	VERB
gs-4062	819	34	through	through	ADP
gs-4062	819	35	patient	patient	ADJ
gs-4062	819	36	self	self	NOUN
gs-4062	819	37	-	-	PUNCT
gs-4062	819	38	report	report	NOUN
gs-4062	819	39	and	and	CCONJ
gs-4062	819	40	pharmacy	pharmacy	NOUN
gs-4062	819	41	refill	refill	NOUN
gs-4062	819	42	records	record	NOUN
gs-4062	819	43	.	.	PUNCT
gs-4062	820	1	the	the	DET
gs-4062	820	2	long	long	ADV
gs-4062	820	3	-	-	PUNCT
gs-4062	820	4	acting	act	VERB
gs-4062	820	5	model	model	NOUN
gs-4062	820	6	demands	demand	VERB
gs-4062	820	7	a	a	DET
gs-4062	820	8	more	more	ADV
gs-4062	820	9	rigid	rigid	ADJ
gs-4062	820	10	,	,	PUNCT
gs-4062	820	11	high	high	ADJ
gs-4062	820	12	-	-	PUNCT
gs-4062	820	13	touch	touch	NOUN
gs-4062	820	14	,	,	PUNCT
gs-4062	820	15	and	and	CCONJ
gs-4062	820	16	precisely	precisely	ADV
gs-4062	820	17	coordinated	coordinated	ADJ
gs-4062	820	18	system	system	NOUN
gs-4062	820	19	.	.	PUNCT
gs-4062	821	1	the	the	DET
gs-4062	821	2	first	first	ADJ
gs-4062	821	3	logistical	logistical	ADJ
gs-4062	821	4	hurdle	hurdle	NOUN
gs-4062	821	5	is	be	AUX
gs-4062	821	6	the	the	DET
gs-4062	821	7	establishment	establishment	NOUN
gs-4062	821	8	of	of	ADP
gs-4062	821	9	a	a	DET
gs-4062	821	10	fail	fail	ADJ
gs-4062	821	11	-	-	PUNCT
gs-4062	821	12	proof	proof	ADJ
gs-4062	821	13	scheduling	scheduling	NOUN
gs-4062	821	14	and	and	CCONJ
gs-4062	821	15	reminder	reminder	NOUN
gs-4062	821	16	system	system	NOUN
gs-4062	821	17	.	.	PUNCT
gs-4062	822	1	a	a	DET
gs-4062	822	2	patient	patient	NOUN
gs-4062	822	3	receiving	receive	VERB
gs-4062	822	4	monthly	monthly	ADJ
gs-4062	822	5	injections	injection	NOUN
gs-4062	822	6	has	have	VERB
gs-4062	822	7	twelve	twelve	NUM
gs-4062	822	8	critical	critical	ADJ
gs-4062	822	9	healthcare	healthcare	NOUN
gs-4062	822	10	engagements	engagement	NOUN
gs-4062	822	11	per	per	ADP
gs-4062	822	12	year	year	NOUN
gs-4062	822	13	that	that	PRON
gs-4062	822	14	can	can	AUX
gs-4062	822	15	not	not	PART
gs-4062	822	16	be	be	AUX
gs-4062	822	17	missed	miss	VERB
gs-4062	822	18	,	,	PUNCT
gs-4062	822	19	compared	compare	VERB
gs-4062	822	20	to	to	ADP
gs-4062	822	21	two	two	NUM
gs-4062	822	22	or	or	CCONJ
gs-4062	822	23	four	four	NUM
gs-4062	822	24	for	for	ADP
gs-4062	822	25	a	a	DET
gs-4062	822	26	patient	patient	NOUN
gs-4062	822	27	on	on	ADP
gs-4062	822	28	oral	oral	ADJ
gs-4062	822	29	therapy	therapy	NOUN
gs-4062	822	30	.	.	PUNCT
gs-4062	823	1	missed	miss	VERB
gs-4062	823	2	injections	injection	NOUN
gs-4062	823	3	risk	risk	VERB
gs-4062	823	4	virological	virological	ADJ
gs-4062	823	5	failure	failure	NOUN
gs-4062	823	6	and	and	CCONJ
gs-4062	823	7	the	the	DET
gs-4062	823	8	development	development	NOUN
gs-4062	823	9	of	of	ADP
gs-4062	823	10	resistance	resistance	NOUN
gs-4062	823	11	,	,	PUNCT
gs-4062	823	12	particularly	particularly	ADV
gs-4062	823	13	during	during	ADP
gs-4062	823	14	the	the	DET
gs-4062	823	15	long	long	ADJ
gs-4062	823	16	pharmacological	pharmacological	NOUN
gs-4062	823	17	"	"	PUNCT
gs-4062	823	18	tail	tail	NOUN
gs-4062	823	19	"	"	PUNCT
gs-4062	823	20	period	period	NOUN
gs-4062	823	21	where	where	SCONJ
gs-4062	823	22	drug	drug	NOUN
gs-4062	823	23	levels	level	NOUN
gs-4062	823	24	dwindle	dwindle	VERB
gs-4062	823	25	below	below	ADP
gs-4062	823	26	the	the	DET
gs-4062	823	27	therapeutic	therapeutic	ADJ
gs-4062	823	28	threshold	threshold	NOUN
gs-4062	823	29	.	.	PUNCT
gs-4062	824	1	clinics	clinic	NOUN
gs-4062	824	2	must	must	AUX
gs-4062	824	3	therefore	therefore	ADV
gs-4062	824	4	invest	invest	VERB
gs-4062	824	5	in	in	ADP
gs-4062	824	6	robust	robust	ADJ
gs-4062	824	7	recall	recall	NOUN
gs-4062	824	8	systems	system	NOUN
gs-4062	824	9	—	—	PUNCT
gs-4062	824	10	using	use	VERB
gs-4062	824	11	text	text	NOUN
gs-4062	824	12	messages	message	NOUN
gs-4062	824	13	,	,	PUNCT
gs-4062	824	14	phone	phone	NOUN
gs-4062	824	15	calls	call	NOUN
gs-4062	824	16	,	,	PUNCT
gs-4062	824	17	and	and	CCONJ
gs-4062	824	18	patient	patient	ADJ
gs-4062	824	19	portals	portal	NOUN
gs-4062	824	20	—	—	PUNCT
gs-4062	824	21	to	to	PART
gs-4062	824	22	ensure	ensure	VERB
gs-4062	824	23	perfect	perfect	ADJ
gs-4062	824	24	adherence	adherence	NOUN
gs-4062	824	25	to	to	ADP
gs-4062	824	26	appointment	appointment	NOUN
gs-4062	824	27	schedules	schedule	NOUN
gs-4062	824	28	.	.	PUNCT
gs-4062	825	1	second	second	ADJ
gs-4062	825	2	,	,	PUNCT
gs-4062	825	3	the	the	DET
gs-4062	825	4	clinic	clinic	NOUN
gs-4062	825	5	must	must	AUX
gs-4062	825	6	be	be	AUX
gs-4062	825	7	physically	physically	ADV
gs-4062	825	8	reconfigured	reconfigure	VERB
gs-4062	825	9	to	to	PART
gs-4062	825	10	handle	handle	VERB
gs-4062	825	11	the	the	DET
gs-4062	825	12	influx	influx	NOUN
gs-4062	825	13	of	of	ADP
gs-4062	825	14	patients	patient	NOUN
gs-4062	825	15	for	for	ADP
gs-4062	825	16	injection	injection	NOUN
gs-4062	825	17	visits	visit	NOUN
gs-4062	825	18	,	,	PUNCT
gs-4062	825	19	which	which	PRON
gs-4062	825	20	require	require	VERB
gs-4062	825	21	more	more	ADJ
gs-4062	825	22	time	time	NOUN
gs-4062	825	23	and	and	CCONJ
gs-4062	825	24	space	space	NOUN
gs-4062	825	25	than	than	ADP
gs-4062	825	26	a	a	DET
gs-4062	825	27	standard	standard	ADJ
gs-4062	825	28	consultation	consultation	NOUN
gs-4062	825	29	.	.	PUNCT
gs-4062	826	1	this	this	PRON
gs-4062	826	2	may	may	AUX
gs-4062	826	3	necessitate	necessitate	VERB
gs-4062	826	4	dedicated	dedicated	ADJ
gs-4062	826	5	injection	injection	NOUN
gs-4062	826	6	rooms	room	NOUN
gs-4062	826	7	and	and	CCONJ
gs-4062	826	8	nursing	nursing	NOUN
gs-4062	826	9	staff	staff	NOUN
gs-4062	826	10	.	.	PUNCT
gs-4062	827	1	the	the	DET
gs-4062	827	2	third	third	ADJ
gs-4062	827	3	,	,	PUNCT
gs-4062	827	4	and	and	CCONJ
gs-4062	827	5	perhaps	perhaps	ADV
gs-4062	827	6	most	most	ADV
gs-4062	827	7	significant	significant	ADJ
gs-4062	827	8	,	,	PUNCT
gs-4062	827	9	challenge	challenge	NOUN
gs-4062	827	10	is	be	AUX
gs-4062	827	11	the	the	DET
gs-4062	827	12	management	management	NOUN
gs-4062	827	13	of	of	ADP
gs-4062	827	14	the	the	DET
gs-4062	827	15	"	"	PUNCT
gs-4062	827	16	tail	tail	NOUN
gs-4062	827	17	"	"	PUNCT
gs-4062	827	18	period	period	NOUN
gs-4062	827	19	.	.	PUNCT
gs-4062	828	1	this	this	DET
gs-4062	828	2	unique	unique	ADJ
gs-4062	828	3	pharmacological	pharmacological	ADJ
gs-4062	828	4	property	property	NOUN
gs-4062	828	5	is	be	AUX
gs-4062	828	6	a	a	DET
gs-4062	828	7	double	double	ADJ
gs-4062	828	8	-	-	PUNCT
gs-4062	828	9	edged	edge	VERB
gs-4062	828	10	sword	sword	NOUN
gs-4062	828	11	.	.	PUNCT
gs-4062	829	1	it	it	PRON
gs-4062	829	2	provides	provide	VERB
gs-4062	829	3	a	a	DET
gs-4062	829	4	grace	grace	NOUN
gs-4062	829	5	period	period	NOUN
gs-4062	829	6	if	if	SCONJ
gs-4062	829	7	an	an	DET
gs-4062	829	8	injection	injection	NOUN
gs-4062	829	9	is	be	AUX
gs-4062	829	10	slightly	slightly	ADV
gs-4062	829	11	delayed	delay	VERB
gs-4062	829	12	,	,	PUNCT
gs-4062	829	13	but	but	CCONJ
gs-4062	829	14	it	it	PRON
gs-4062	829	15	also	also	ADV
gs-4062	829	16	creates	create	VERB
gs-4062	829	17	a	a	DET
gs-4062	829	18	prolonged	prolonged	ADJ
gs-4062	829	19	vulnerability	vulnerability	NOUN
gs-4062	829	20	window	window	NOUN
gs-4062	829	21	.	.	PUNCT
gs-4062	830	1	if	if	SCONJ
gs-4062	830	2	a	a	DET
gs-4062	830	3	patient	patient	NOUN
gs-4062	830	4	decides	decide	VERB
gs-4062	830	5	to	to	PART
gs-4062	830	6	discontinue	discontinue	VERB
gs-4062	830	7	injections	injection	NOUN
gs-4062	830	8	or	or	CCONJ
gs-4062	830	9	is	be	AUX
gs-4062	830	10	lost	lose	VERB
gs-4062	830	11	to	to	PART
gs-4062	830	12	follow	follow	VERB
gs-4062	830	13	-	-	PUNCT
gs-4062	830	14	up	up	NOUN
gs-4062	830	15	,	,	PUNCT
gs-4062	830	16	they	they	PRON
gs-4062	830	17	are	be	AUX
gs-4062	830	18	not	not	PART
gs-4062	830	19	truly	truly	ADV
gs-4062	830	20	off	off	ADP
gs-4062	830	21	therapy	therapy	NOUN
gs-4062	830	22	for	for	ADP
gs-4062	830	23	many	many	ADJ
gs-4062	830	24	months	month	NOUN
gs-4062	830	25	.	.	PUNCT
gs-4062	831	1	during	during	ADP
gs-4062	831	2	this	this	DET
gs-4062	831	3	time	time	NOUN
gs-4062	831	4	,	,	PUNCT
gs-4062	831	5	subtherapeutic	subtherapeutic	ADJ
gs-4062	831	6	drug	drug	NOUN
gs-4062	831	7	levels	level	NOUN
gs-4062	831	8	can	can	AUX
gs-4062	831	9	apply	apply	VERB
gs-4062	831	10	selective	selective	ADJ
gs-4062	831	11	pressure	pressure	NOUN
gs-4062	831	12	on	on	ADP
gs-4062	831	13	the	the	DET
gs-4062	831	14	virus	virus	NOUN
gs-4062	831	15	,	,	PUNCT
gs-4062	831	16	fostering	foster	VERB
gs-4062	831	17	the	the	DET
gs-4062	831	18	georgian	georgian	NOUN
gs-4062	831	19	scientists/	scientists/	NUM
gs-4062	831	20	.	.	PUNCT
gs-4062	832	1	7	7	NUM
gs-4062	832	2	n	n	PRON
gs-4062	832	3	3	3	NUM
gs-4062	832	4	,	,	PUNCT
gs-4062	832	5	2025	2025	NUM
gs-4062	832	6	557	557	NUM
gs-4062	832	7	emergence	emergence	NOUN
gs-4062	832	8	of	of	ADP
gs-4062	832	9	resistance	resistance	NOUN
gs-4062	832	10	mutations	mutation	NOUN
gs-4062	832	11	that	that	PRON
gs-4062	832	12	can	can	AUX
gs-4062	832	13	compromise	compromise	VERB
gs-4062	832	14	future	future	ADJ
gs-4062	832	15	treatment	treatment	NOUN
gs-4062	832	16	options	option	NOUN
gs-4062	832	17	,	,	PUNCT
gs-4062	832	18	including	include	VERB
gs-4062	832	19	other	other	ADJ
gs-4062	832	20	instis	instis	NOUN
gs-4062	832	21	and	and	CCONJ
gs-4062	832	22	nnrtis	nnrtis	NOUN
gs-4062	832	23	.	.	PUNCT
gs-4062	833	1	this	this	PRON
gs-4062	833	2	necessitates	necessitate	VERB
gs-4062	833	3	enhanced	enhance	VERB
gs-4062	833	4	patient	patient	ADJ
gs-4062	833	5	education	education	NOUN
gs-4062	833	6	and	and	CCONJ
gs-4062	833	7	a	a	DET
gs-4062	833	8	formal	formal	ADJ
gs-4062	833	9	"	"	PUNCT
gs-4062	833	10	exit	exit	NOUN
gs-4062	833	11	strategy	strategy	NOUN
gs-4062	833	12	"	"	PUNCT
gs-4062	833	13	for	for	ADP
gs-4062	833	14	any	any	DET
gs-4062	833	15	patient	patient	NOUN
gs-4062	833	16	wishing	wish	VERB
gs-4062	833	17	to	to	PART
gs-4062	833	18	stop	stop	VERB
gs-4062	833	19	la	la	ADJ
gs-4062	833	20	-	-	NOUN
gs-4062	833	21	art	art	NOUN
gs-4062	833	22	,	,	PUNCT
gs-4062	833	23	which	which	PRON
gs-4062	833	24	should	should	AUX
gs-4062	833	25	include	include	VERB
gs-4062	833	26	a	a	DET
gs-4062	833	27	prompt	prompt	ADJ
gs-4062	833	28	switch	switch	NOUN
gs-4062	833	29	to	to	ADP
gs-4062	833	30	a	a	DET
gs-4062	833	31	fully	fully	ADV
gs-4062	833	32	suppressive	suppressive	ADJ
gs-4062	833	33	oral	oral	ADJ
gs-4062	833	34	regimen	regiman	NOUN
gs-4062	833	35	to	to	PART
gs-4062	833	36	cover	cover	VERB
gs-4062	833	37	the	the	DET
gs-4062	833	38	tail	tail	NOUN
gs-4062	833	39	period	period	NOUN
gs-4062	833	40	.	.	PUNCT
gs-4062	834	1	furthermore	furthermore	ADV
gs-4062	834	2	,	,	PUNCT
gs-4062	834	3	it	it	PRON
gs-4062	834	4	requires	require	VERB
gs-4062	834	5	that	that	SCONJ
gs-4062	834	6	clinics	clinic	NOUN
gs-4062	834	7	have	have	VERB
gs-4062	834	8	rapid	rapid	ADJ
gs-4062	834	9	access	access	NOUN
gs-4062	834	10	to	to	ADP
gs-4062	834	11	hiv	hiv	PROPN
gs-4062	834	12	rna	rna	NOUN
gs-4062	834	13	testing	testing	NOUN
gs-4062	834	14	and	and	CCONJ
gs-4062	834	15	genotypic	genotypic	NOUN
gs-4062	834	16	resistance	resistance	NOUN
gs-4062	834	17	testing	testing	NOUN
gs-4062	834	18	to	to	PART
gs-4062	834	19	quickly	quickly	ADV
gs-4062	834	20	identify	identify	VERB
gs-4062	834	21	and	and	CCONJ
gs-4062	834	22	manage	manage	VERB
gs-4062	834	23	any	any	DET
gs-4062	834	24	breakthrough	breakthrough	ADJ
gs-4062	834	25	viremia	viremia	NOUN
gs-4062	834	26	.	.	PUNCT
gs-4062	835	1	finally	finally	ADV
gs-4062	835	2	,	,	PUNCT
gs-4062	835	3	the	the	DET
gs-4062	835	4	storage	storage	NOUN
gs-4062	835	5	and	and	CCONJ
gs-4062	835	6	preparation	preparation	NOUN
gs-4062	835	7	of	of	ADP
gs-4062	835	8	the	the	DET
gs-4062	835	9	medications	medication	NOUN
gs-4062	835	10	themselves	themselves	PRON
gs-4062	835	11	add	add	VERB
gs-4062	835	12	another	another	DET
gs-4062	835	13	layer	layer	NOUN
gs-4062	835	14	of	of	ADP
gs-4062	835	15	complexity	complexity	NOUN
gs-4062	835	16	.	.	PUNCT
gs-4062	836	1	the	the	DET
gs-4062	836	2	formulations	formulation	NOUN
gs-4062	836	3	require	require	VERB
gs-4062	836	4	refrigeration	refrigeration	NOUN
gs-4062	836	5	and	and	CCONJ
gs-4062	836	6	must	must	AUX
gs-4062	836	7	be	be	AUX
gs-4062	836	8	brought	bring	VERB
gs-4062	836	9	to	to	AUX
gs-4062	836	10	room	room	NOUN
gs-4062	836	11	temperature	temperature	NOUN
gs-4062	836	12	before	before	ADP
gs-4062	836	13	administration	administration	NOUN
gs-4062	836	14	.	.	PUNCT
gs-4062	837	1	the	the	DET
gs-4062	837	2	large	large	ADJ
gs-4062	837	3	volume	volume	NOUN
gs-4062	837	4	of	of	ADP
gs-4062	837	5	the	the	DET
gs-4062	837	6	injection	injection	NOUN
gs-4062	837	7	necessitates	necessitate	VERB
gs-4062	837	8	a	a	DET
gs-4062	837	9	slow	slow	ADJ
gs-4062	837	10	,	,	PUNCT
gs-4062	837	11	deep	deep	ADJ
gs-4062	837	12	intramuscular	intramuscular	ADJ
gs-4062	837	13	injection	injection	NOUN
gs-4062	837	14	,	,	PUNCT
gs-4062	837	15	which	which	PRON
gs-4062	837	16	can	can	AUX
gs-4062	837	17	be	be	AUX
gs-4062	837	18	painful	painful	ADJ
gs-4062	837	19	and	and	CCONJ
gs-4062	837	20	lead	lead	VERB
gs-4062	837	21	to	to	ADP
gs-4062	837	22	post	post	ADJ
gs-4062	837	23	-	-	ADJ
gs-4062	837	24	injection	injection	NOUN
gs-4062	837	25	reactions	reaction	NOUN
gs-4062	837	26	.	.	PUNCT
gs-4062	838	1	managing	manage	VERB
gs-4062	838	2	these	these	DET
gs-4062	838	3	reactions	reaction	NOUN
gs-4062	838	4	—	—	PUNCT
gs-4062	838	5	through	through	ADP
gs-4062	838	6	premedication	premedication	NOUN
gs-4062	838	7	with	with	ADP
gs-4062	838	8	analgesics	analgesic	NOUN
gs-4062	838	9	,	,	PUNCT
gs-4062	838	10	the	the	DET
gs-4062	838	11	use	use	NOUN
gs-4062	838	12	of	of	ADP
gs-4062	838	13	vibrating	vibrate	VERB
gs-4062	838	14	devices	device	NOUN
gs-4062	838	15	to	to	PART
gs-4062	838	16	distract	distract	VERB
gs-4062	838	17	from	from	ADP
gs-4062	838	18	pain	pain	NOUN
gs-4062	838	19	,	,	PUNCT
gs-4062	838	20	and	and	CCONJ
gs-4062	838	21	proper	proper	ADJ
gs-4062	838	22	injection	injection	NOUN
gs-4062	838	23	technique	technique	NOUN
gs-4062	838	24	—	—	PUNCT
gs-4062	838	25	becomes	become	VERB
gs-4062	838	26	a	a	DET
gs-4062	838	27	new	new	ADJ
gs-4062	838	28	nursing	nursing	NOUN
gs-4062	838	29	competency	competency	NOUN
gs-4062	838	30	.	.	PUNCT
gs-4062	839	1	thus	thus	ADV
gs-4062	839	2	,	,	PUNCT
gs-4062	839	3	the	the	DET
gs-4062	839	4	successful	successful	ADJ
gs-4062	839	5	implementation	implementation	NOUN
gs-4062	839	6	of	of	ADP
gs-4062	839	7	la	la	ADJ
gs-4062	839	8	-	-	NOUN
gs-4062	839	9	art	art	NOUN
gs-4062	839	10	is	be	AUX
gs-4062	839	11	as	as	ADV
gs-4062	839	12	much	much	ADJ
gs-4062	839	13	a	a	DET
gs-4062	839	14	test	test	NOUN
gs-4062	839	15	of	of	ADP
gs-4062	839	16	healthcare	healthcare	NOUN
gs-4062	839	17	system	system	NOUN
gs-4062	839	18	engineering	engineering	NOUN
gs-4062	839	19	as	as	SCONJ
gs-4062	839	20	it	it	PRON
gs-4062	839	21	is	be	AUX
gs-4062	839	22	of	of	ADP
gs-4062	839	23	clinical	clinical	ADJ
gs-4062	839	24	efficacy	efficacy	NOUN
gs-4062	839	25	.	.	PUNCT
gs-4062	840	1	it	it	PRON
gs-4062	840	2	demands	demand	VERB
gs-4062	840	3	investment	investment	NOUN
gs-4062	840	4	,	,	PUNCT
gs-4062	840	5	training	training	NOUN
gs-4062	840	6	,	,	PUNCT
gs-4062	840	7	and	and	CCONJ
gs-4062	840	8	a	a	DET
gs-4062	840	9	re	re	NOUN
gs-4062	840	10	-	-	NOUN
gs-4062	840	11	imagining	imagining	NOUN
gs-4062	840	12	of	of	ADP
gs-4062	840	13	the	the	DET
gs-4062	840	14	traditional	traditional	ADJ
gs-4062	840	15	hiv	hiv	PROPN
gs-4062	840	16	care	care	PROPN
gs-4062	840	17	model	model	PROPN
gs-4062	840	18	.	.	PUNCT
gs-4062	841	1	novel	novel	ADJ
gs-4062	841	2	mechanisms	mechanism	NOUN
gs-4062	841	3	and	and	CCONJ
gs-4062	841	4	the	the	DET
gs-4062	841	5	end	end	NOUN
gs-4062	841	6	of	of	ADP
gs-4062	841	7	the	the	DET
gs-4062	841	8	road	road	NOUN
gs-4062	841	9	:	:	PUNCT
gs-4062	841	10	lenacapavir	lenacapavir	NOUN
gs-4062	841	11	and	and	CCONJ
gs-4062	841	12	the	the	DET
gs-4062	841	13	treatment	treatment	NOUN
gs-4062	841	14	-	-	PUNCT
gs-4062	841	15	experienced	experience	VERB
gs-4062	841	16	patient	patient	NOUN
gs-4062	841	17	the	the	DET
gs-4062	841	18	approval	approval	NOUN
gs-4062	841	19	of	of	ADP
gs-4062	841	20	lenacapavir	lenacapavir	PROPN
gs-4062	841	21	,	,	PUNCT
gs-4062	841	22	a	a	DET
gs-4062	841	23	first	first	ADJ
gs-4062	841	24	-	-	PUNCT
gs-4062	841	25	in	in	ADP
gs-4062	841	26	-	-	PUNCT
gs-4062	841	27	class	class	NOUN
gs-4062	841	28	capsid	capsid	NOUN
gs-4062	841	29	inhibitor	inhibitor	NOUN
gs-4062	841	30	,	,	PUNCT
gs-4062	841	31	represents	represent	VERB
gs-4062	841	32	a	a	DET
gs-4062	841	33	watershed	watershed	ADJ
gs-4062	841	34	moment	moment	NOUN
gs-4062	841	35	for	for	ADP
gs-4062	841	36	the	the	DET
gs-4062	841	37	most	most	ADV
gs-4062	841	38	vulnerable	vulnerable	ADJ
gs-4062	841	39	segment	segment	NOUN
gs-4062	841	40	of	of	ADP
gs-4062	841	41	the	the	DET
gs-4062	841	42	hiv	hiv	PROPN
gs-4062	841	43	-	-	PUNCT
gs-4062	841	44	positive	positive	ADJ
gs-4062	841	45	population	population	NOUN
gs-4062	841	46	:	:	PUNCT
gs-4062	841	47	those	those	PRON
gs-4062	841	48	with	with	ADP
gs-4062	841	49	multidrug	multidrug	NOUN
gs-4062	841	50	-	-	PUNCT
gs-4062	841	51	resistant	resistant	ADJ
gs-4062	841	52	virus	virus	NOUN
gs-4062	841	53	for	for	ADP
gs-4062	841	54	whom	whom	PRON
gs-4062	841	55	effective	effective	ADJ
gs-4062	841	56	treatment	treatment	NOUN
gs-4062	841	57	options	option	NOUN
gs-4062	841	58	were	be	AUX
gs-4062	841	59	nearly	nearly	ADV
gs-4062	841	60	exhausted	exhausted	ADJ
gs-4062	841	61	.	.	PUNCT
gs-4062	842	1	the	the	DET
gs-4062	842	2	discussion	discussion	NOUN
gs-4062	842	3	around	around	ADP
gs-4062	842	4	lenacapavir	lenacapavir	PROPN
gs-4062	842	5	is	be	AUX
gs-4062	842	6	not	not	PART
gs-4062	842	7	merely	merely	ADV
gs-4062	842	8	about	about	ADP
gs-4062	842	9	another	another	DET
gs-4062	842	10	new	new	ADJ
gs-4062	842	11	drug	drug	NOUN
gs-4062	842	12	;	;	PUNCT
gs-4062	842	13	it	it	PRON
gs-4062	842	14	is	be	AUX
gs-4062	842	15	about	about	ADP
gs-4062	842	16	the	the	DET
gs-4062	842	17	validation	validation	NOUN
gs-4062	842	18	of	of	ADP
gs-4062	842	19	a	a	DET
gs-4062	842	20	new	new	ADJ
gs-4062	842	21	therapeutic	therapeutic	ADJ
gs-4062	842	22	target	target	NOUN
gs-4062	842	23	and	and	CCONJ
gs-4062	842	24	the	the	DET
gs-4062	842	25	promise	promise	NOUN
gs-4062	842	26	it	it	PRON
gs-4062	842	27	holds	hold	VERB
gs-4062	842	28	for	for	ADP
gs-4062	842	29	the	the	DET
gs-4062	842	30	future	future	NOUN
gs-4062	842	31	.	.	PUNCT
gs-4062	843	1	the	the	DET
gs-4062	843	2	capsid	capsid	PROPN
gs-4062	843	3	,	,	PUNCT
gs-4062	843	4	the	the	DET
gs-4062	843	5	protein	protein	NOUN
gs-4062	843	6	shell	shell	NOUN
gs-4062	843	7	that	that	PRON
gs-4062	843	8	protects	protect	VERB
gs-4062	843	9	the	the	DET
gs-4062	843	10	viral	viral	ADJ
gs-4062	843	11	genome	genome	NOUN
gs-4062	843	12	,	,	PUNCT
gs-4062	843	13	was	be	AUX
gs-4062	843	14	long	long	ADV
gs-4062	843	15	considered	consider	VERB
gs-4062	843	16	an	an	DET
gs-4062	843	17	"	"	PUNCT
gs-4062	843	18	undruggable	undruggable	ADJ
gs-4062	843	19	"	"	PUNCT
gs-4062	843	20	target	target	NOUN
gs-4062	843	21	.	.	PUNCT
gs-4062	844	1	lenacapavir	lenacapavir	PROPN
gs-4062	844	2	’s	’s	PART
gs-4062	844	3	success	success	NOUN
gs-4062	844	4	proves	prove	VERB
gs-4062	844	5	otherwise	otherwise	ADV
gs-4062	844	6	and	and	CCONJ
gs-4062	844	7	opens	open	VERB
gs-4062	844	8	up	up	ADP
gs-4062	844	9	a	a	DET
gs-4062	844	10	new	new	ADJ
gs-4062	844	11	frontier	frontier	NOUN
gs-4062	844	12	for	for	ADP
gs-4062	844	13	drug	drug	NOUN
gs-4062	844	14	discovery	discovery	NOUN
gs-4062	844	15	.	.	PUNCT
gs-4062	845	1	its	its	PRON
gs-4062	845	2	mechanism	mechanism	NOUN
gs-4062	845	3	of	of	ADP
gs-4062	845	4	action	action	NOUN
gs-4062	845	5	is	be	AUX
gs-4062	845	6	a	a	DET
gs-4062	845	7	masterpiece	masterpiece	NOUN
gs-4062	845	8	of	of	ADP
gs-4062	845	9	multi	multi	ADJ
gs-4062	845	10	-	-	ADJ
gs-4062	845	11	stage	stage	NOUN
gs-4062	845	12	inhibition	inhibition	NOUN
gs-4062	845	13	,	,	PUNCT
gs-4062	845	14	which	which	PRON
gs-4062	845	15	explains	explain	VERB
gs-4062	845	16	its	its	PRON
gs-4062	845	17	high	high	ADJ
gs-4062	845	18	barrier	barrier	NOUN
gs-4062	845	19	to	to	ADP
gs-4062	845	20	resistance	resistance	NOUN
gs-4062	845	21	.	.	PUNCT
gs-4062	846	1	by	by	ADP
gs-4062	846	2	stabilizing	stabilize	VERB
gs-4062	846	3	the	the	DET
gs-4062	846	4	capsid	capsid	NOUN
gs-4062	846	5	,	,	PUNCT
gs-4062	846	6	it	it	PRON
gs-4062	846	7	prevents	prevent	VERB
gs-4062	846	8	the	the	DET
gs-4062	846	9	uncoating	uncoating	NOUN
gs-4062	846	10	necessary	necessary	ADJ
gs-4062	846	11	to	to	PART
gs-4062	846	12	release	release	VERB
gs-4062	846	13	the	the	DET
gs-4062	846	14	viral	viral	ADJ
gs-4062	846	15	replication	replication	NOUN
gs-4062	846	16	complex	complex	NOUN
gs-4062	846	17	into	into	ADP
gs-4062	846	18	the	the	DET
gs-4062	846	19	cytoplasm	cytoplasm	NOUN
gs-4062	846	20	.	.	PUNCT
gs-4062	847	1	it	it	PRON
gs-4062	847	2	also	also	ADV
gs-4062	847	3	disrupts	disrupt	VERB
gs-4062	847	4	the	the	DET
gs-4062	847	5	formation	formation	NOUN
gs-4062	847	6	of	of	ADP
gs-4062	847	7	new	new	ADJ
gs-4062	847	8	capsids	capsid	NOUN
gs-4062	847	9	,	,	PUNCT
gs-4062	847	10	preventing	prevent	VERB
gs-4062	847	11	the	the	DET
gs-4062	847	12	proper	proper	ADJ
gs-4062	847	13	assembly	assembly	NOUN
gs-4062	847	14	of	of	ADP
gs-4062	847	15	mature	mature	ADJ
gs-4062	847	16	virions	virion	NOUN
gs-4062	847	17	.	.	PUNCT
gs-4062	848	1	furthermore	furthermore	ADV
gs-4062	848	2	,	,	PUNCT
gs-4062	848	3	it	it	PRON
gs-4062	848	4	interferes	interfere	VERB
gs-4062	848	5	with	with	ADP
gs-4062	848	6	the	the	DET
gs-4062	848	7	nuclear	nuclear	ADJ
gs-4062	848	8	import	import	NOUN
gs-4062	848	9	of	of	ADP
gs-4062	848	10	the	the	DET
gs-4062	848	11	viral	viral	ADJ
gs-4062	848	12	dna	dna	NOUN
gs-4062	848	13	,	,	PUNCT
gs-4062	848	14	a	a	DET
gs-4062	848	15	critical	critical	ADJ
gs-4062	848	16	and	and	CCONJ
gs-4062	848	17	previously	previously	ADV
gs-4062	848	18	untargeted	untargete	VERB
gs-4062	848	19	step	step	NOUN
gs-4062	848	20	in	in	ADP
gs-4062	848	21	the	the	DET
gs-4062	848	22	life	life	NOUN
gs-4062	848	23	cycle	cycle	NOUN
gs-4062	848	24	.	.	PUNCT
gs-4062	849	1	this	this	DET
gs-4062	849	2	multipronged	multipronge	VERB
gs-4062	849	3	attack	attack	NOUN
gs-4062	849	4	means	mean	VERB
gs-4062	849	5	the	the	DET
gs-4062	849	6	virus	virus	NOUN
gs-4062	849	7	must	must	AUX
gs-4062	849	8	develop	develop	VERB
gs-4062	849	9	multiple	multiple	ADJ
gs-4062	849	10	,	,	PUNCT
gs-4062	849	11	concurrent	concurrent	ADJ
gs-4062	849	12	mutations	mutation	NOUN
gs-4062	849	13	to	to	PART
gs-4062	849	14	escape	escape	VERB
gs-4062	849	15	the	the	DET
gs-4062	849	16	drug	drug	NOUN
gs-4062	849	17	’s	’s	PART
gs-4062	849	18	pressure	pressure	NOUN
gs-4062	849	19	,	,	PUNCT
gs-4062	849	20	a	a	DET
gs-4062	849	21	feat	feat	NOUN
gs-4062	849	22	that	that	PRON
gs-4062	849	23	is	be	AUX
gs-4062	849	24	far	far	ADV
gs-4062	849	25	more	more	ADV
gs-4062	849	26	difficult	difficult	ADJ
gs-4062	849	27	than	than	ADP
gs-4062	849	28	evolving	evolve	VERB
gs-4062	849	29	resistance	resistance	NOUN
gs-4062	849	30	to	to	ADP
gs-4062	849	31	a	a	DET
gs-4062	849	32	drug	drug	NOUN
gs-4062	849	33	with	with	ADP
gs-4062	849	34	a	a	DET
gs-4062	849	35	single	single	ADJ
gs-4062	849	36	point	point	NOUN
gs-4062	849	37	of	of	ADP
gs-4062	849	38	action	action	NOUN
gs-4062	849	39	.	.	PUNCT
gs-4062	850	1	the	the	DET
gs-4062	850	2	clinical	clinical	ADJ
gs-4062	850	3	results	result	NOUN
gs-4062	850	4	in	in	ADP
gs-4062	850	5	heavily	heavily	ADV
gs-4062	850	6	treatment	treatment	NOUN
gs-4062	850	7	-	-	PUNCT
gs-4062	850	8	experienced	experience	VERB
gs-4062	850	9	patients	patient	NOUN
gs-4062	850	10	are	be	AUX
gs-4062	850	11	dramatic	dramatic	ADJ
gs-4062	850	12	,	,	PUNCT
gs-4062	850	13	but	but	CCONJ
gs-4062	850	14	the	the	DET
gs-4062	850	15	more	more	ADV
gs-4062	850	16	forward	forward	ADV
gs-4062	850	17	-	-	PUNCT
gs-4062	850	18	looking	look	VERB
gs-4062	850	19	discussion	discussion	NOUN
gs-4062	850	20	revolves	revolve	VERB
gs-4062	850	21	around	around	ADP
gs-4062	850	22	its	its	PRON
gs-4062	850	23	potential	potential	NOUN
gs-4062	850	24	in	in	ADP
gs-4062	850	25	earlier	early	ADJ
gs-4062	850	26	lines	line	NOUN
gs-4062	850	27	of	of	ADP
gs-4062	850	28	therapy	therapy	NOUN
gs-4062	850	29	and	and	CCONJ
gs-4062	850	30	in	in	ADP
gs-4062	850	31	longacting	longacting	NOUN
gs-4062	850	32	prevention	prevention	NOUN
gs-4062	850	33	.	.	PUNCT
gs-4062	851	1	its	its	PRON
gs-4062	851	2	astonishingly	astonishingly	ADV
gs-4062	851	3	long	long	ADJ
gs-4062	851	4	half	half	ADJ
gs-4062	851	5	-	-	PUNCT
gs-4062	851	6	life	life	NOUN
gs-4062	851	7	makes	make	VERB
gs-4062	851	8	it	it	PRON
gs-4062	851	9	an	an	DET
gs-4062	851	10	ideal	ideal	ADJ
gs-4062	851	11	anchor	anchor	NOUN
gs-4062	851	12	for	for	ADP
gs-4062	851	13	future	future	ADJ
gs-4062	851	14	long	long	ADV
gs-4062	851	15	-	-	PUNCT
gs-4062	851	16	acting	act	VERB
gs-4062	851	17	regimens	regimen	NOUN
gs-4062	851	18	.	.	PUNCT
gs-4062	852	1	imagine	imagine	VERB
gs-4062	852	2	a	a	DET
gs-4062	852	3	future	future	NOUN
gs-4062	852	4	where	where	SCONJ
gs-4062	852	5	a	a	DET
gs-4062	852	6	patient	patient	NOUN
gs-4062	852	7	receives	receive	VERB
gs-4062	852	8	a	a	DET
gs-4062	852	9	semi	semi	ADJ
gs-4062	852	10	-	-	ADJ
gs-4062	852	11	annual	annual	ADJ
gs-4062	852	12	subcutaneous	subcutaneous	ADJ
gs-4062	852	13	injection	injection	NOUN
gs-4062	852	14	of	of	ADP
gs-4062	852	15	lenacapavir	lenacapavir	NOUN
gs-4062	852	16	paired	pair	VERB
gs-4062	852	17	with	with	ADP
gs-4062	852	18	a	a	DET
gs-4062	852	19	semi	semi	ADJ
gs-4062	852	20	-	-	ADJ
gs-4062	852	21	annual	annual	ADJ
gs-4062	852	22	injection	injection	NOUN
gs-4062	852	23	of	of	ADP
gs-4062	852	24	a	a	DET
gs-4062	852	25	long	long	ADV
gs-4062	852	26	-	-	PUNCT
gs-4062	852	27	acting	act	VERB
gs-4062	852	28	version	version	NOUN
gs-4062	852	29	of	of	ADP
gs-4062	852	30	another	another	DET
gs-4062	852	31	novel	novel	ADJ
gs-4062	852	32	agent	agent	NOUN
gs-4062	852	33	,	,	PUNCT
gs-4062	852	34	effectively	effectively	ADV
gs-4062	852	35	creating	create	VERB
gs-4062	852	36	a	a	DET
gs-4062	852	37	once	once	ADV
gs-4062	852	38	-	-	PUNCT
gs-4062	852	39	yearly	yearly	ADJ
gs-4062	852	40	hiv	hiv	PROPN
gs-4062	852	41	treatment	treatment	NOUN
gs-4062	852	42	regimen	regiman	NOUN
gs-4062	852	43	.	.	PUNCT
gs-4062	853	1	this	this	PRON
gs-4062	853	2	is	be	AUX
gs-4062	853	3	no	no	PRON
gs-4062	853	4	longer	long	ADJ
gs-4062	853	5	science	science	NOUN
gs-4062	853	6	fiction	fiction	NOUN
gs-4062	853	7	;	;	PUNCT
gs-4062	853	8	it	it	PRON
gs-4062	853	9	is	be	AUX
gs-4062	853	10	the	the	DET
gs-4062	853	11	subject	subject	NOUN
gs-4062	853	12	of	of	ADP
gs-4062	853	13	ongoing	ongoing	ADJ
gs-4062	853	14	clinical	clinical	ADJ
gs-4062	853	15	development	development	NOUN
gs-4062	853	16	.	.	PUNCT
gs-4062	854	1	furthermore	furthermore	ADV
gs-4062	854	2	,	,	PUNCT
gs-4062	854	3	its	its	PRON
gs-4062	854	4	potency	potency	NOUN
gs-4062	854	5	and	and	CCONJ
gs-4062	854	6	unique	unique	ADJ
gs-4062	854	7	mechanism	mechanism	NOUN
gs-4062	854	8	make	make	VERB
gs-4062	854	9	it	it	PRON
gs-4062	854	10	a	a	DET
gs-4062	854	11	compelling	compelling	ADJ
gs-4062	854	12	candidate	candidate	NOUN
gs-4062	854	13	for	for	ADP
gs-4062	854	14	long	long	ADV
gs-4062	854	15	-	-	PUNCT
gs-4062	854	16	acting	act	VERB
gs-4062	854	17	prep	prep	NOUN
gs-4062	854	18	,	,	PUNCT
gs-4062	854	19	potentially	potentially	ADV
gs-4062	854	20	offering	offer	VERB
gs-4062	854	21	six	six	NUM
gs-4062	854	22	months	month	NOUN
gs-4062	854	23	of	of	ADP
gs-4062	854	24	protection	protection	NOUN
gs-4062	854	25	against	against	ADP
gs-4062	854	26	hiv	hiv	PROPN
gs-4062	854	27	acquisition	acquisition	NOUN
gs-4062	854	28	with	with	ADP
gs-4062	854	29	a	a	DET
gs-4062	854	30	single	single	ADJ
gs-4062	854	31	injection	injection	NOUN
gs-4062	854	32	.	.	PUNCT
gs-4062	855	1	the	the	DET
gs-4062	855	2	discussion	discussion	NOUN
gs-4062	855	3	,	,	PUNCT
gs-4062	855	4	therefore	therefore	ADV
gs-4062	855	5	,	,	PUNCT
gs-4062	855	6	must	must	AUX
gs-4062	855	7	position	position	VERB
gs-4062	855	8	lenacapavir	lenacapavir	NOUN
gs-4062	855	9	not	not	PART
gs-4062	855	10	just	just	ADV
gs-4062	855	11	as	as	ADP
gs-4062	855	12	a	a	DET
gs-4062	855	13	salvage	salvage	NOUN
gs-4062	855	14	therapy	therapy	NOUN
gs-4062	855	15	,	,	PUNCT
gs-4062	855	16	but	but	CCONJ
gs-4062	855	17	as	as	ADP
gs-4062	855	18	a	a	DET
gs-4062	855	19	pioneer	pioneer	NOUN
gs-4062	855	20	—	—	PUNCT
gs-4062	855	21	the	the	DET
gs-4062	855	22	first	first	ADJ
gs-4062	855	23	representative	representative	NOUN
gs-4062	855	24	of	of	ADP
gs-4062	855	25	a	a	DET
gs-4062	855	26	new	new	ADJ
gs-4062	855	27	generation	generation	NOUN
gs-4062	855	28	of	of	ADP
gs-4062	855	29	ultra	ultra	ADJ
gs-4062	855	30	-	-	ADJ
gs-4062	855	31	longacting	longacting	ADJ
gs-4062	855	32	,	,	PUNCT
gs-4062	855	33	resistance	resistance	NOUN
gs-4062	855	34	-	-	PUNCT
gs-4062	855	35	proof	proof	ADJ
gs-4062	855	36	agents	agent	NOUN
gs-4062	855	37	that	that	PRON
gs-4062	855	38	will	will	AUX
gs-4062	855	39	eventually	eventually	ADV
gs-4062	855	40	become	become	VERB
gs-4062	855	41	the	the	DET
gs-4062	855	42	standard	standard	NOUN
gs-4062	855	43	of	of	ADP
gs-4062	855	44	care	care	NOUN
gs-4062	855	45	for	for	ADP
gs-4062	855	46	all	all	PRON
gs-4062	855	47	.	.	PUNCT
gs-4062	856	1	georgian	georgian	NOUN
gs-4062	856	2	scientists/	scientists/	NUM
gs-4062	856	3	.	.	PUNCT
gs-4062	857	1	7	7	NUM
gs-4062	857	2	n	n	PRON
gs-4062	857	3	3	3	NUM
gs-4062	857	4	,	,	PUNCT
gs-4062	857	5	2025	2025	NUM
gs-4062	857	6	558	558	NUM
gs-4062	857	7	the	the	DET
gs-4062	857	8	dawn	dawn	NOUN
gs-4062	857	9	of	of	ADP
gs-4062	857	10	immunotherapies	immunotherapy	NOUN
gs-4062	857	11	:	:	PUNCT
gs-4062	857	12	bnabs	bnab	NOUN
gs-4062	857	13	and	and	CCONJ
gs-4062	857	14	the	the	DET
gs-4062	857	15	bridge	bridge	NOUN
gs-4062	857	16	to	to	ADP
gs-4062	857	17	a	a	DET
gs-4062	857	18	cure	cure	NOUN
gs-4062	857	19	the	the	DET
gs-4062	857	20	exploration	exploration	NOUN
gs-4062	857	21	of	of	ADP
gs-4062	857	22	broadly	broadly	ADV
gs-4062	857	23	neutralizing	neutralize	VERB
gs-4062	857	24	antibodies	antibody	NOUN
gs-4062	857	25	(	(	PUNCT
gs-4062	857	26	bnabs	bnab	NOUN
gs-4062	857	27	)	)	PUNCT
gs-4062	857	28	marks	mark	VERB
gs-4062	857	29	a	a	DET
gs-4062	857	30	significant	significant	ADJ
gs-4062	857	31	departure	departure	NOUN
gs-4062	857	32	from	from	ADP
gs-4062	857	33	traditional	traditional	ADJ
gs-4062	857	34	small	small	ADJ
gs-4062	857	35	-	-	PUNCT
gs-4062	857	36	molecule	molecule	NOUN
gs-4062	857	37	antiretroviral	antiretroviral	ADJ
gs-4062	857	38	therapy	therapy	NOUN
gs-4062	857	39	and	and	CCONJ
gs-4062	857	40	ventures	venture	NOUN
gs-4062	857	41	into	into	ADP
gs-4062	857	42	the	the	DET
gs-4062	857	43	realm	realm	NOUN
gs-4062	857	44	of	of	ADP
gs-4062	857	45	immunotherapy	immunotherapy	NOUN
gs-4062	857	46	.	.	PUNCT
gs-4062	858	1	the	the	DET
gs-4062	858	2	initial	initial	ADJ
gs-4062	858	3	results	result	NOUN
gs-4062	858	4	of	of	ADP
gs-4062	858	5	bnab	bnab	NOUN
gs-4062	858	6	monotherapy	monotherapy	NOUN
gs-4062	858	7	were	be	AUX
gs-4062	858	8	humbling	humble	VERB
gs-4062	858	9	,	,	PUNCT
gs-4062	858	10	teaching	teach	VERB
gs-4062	858	11	a	a	DET
gs-4062	858	12	crucial	crucial	ADJ
gs-4062	858	13	lesson	lesson	NOUN
gs-4062	858	14	about	about	ADP
gs-4062	858	15	the	the	DET
gs-4062	858	16	cunning	cunning	ADJ
gs-4062	858	17	adaptability	adaptability	NOUN
gs-4062	858	18	of	of	ADP
gs-4062	858	19	hiv	hiv	PROPN
gs-4062	858	20	.	.	PUNCT
gs-4062	859	1	however	however	ADV
gs-4062	859	2	,	,	PUNCT
gs-4062	859	3	this	this	DET
gs-4062	859	4	failure	failure	NOUN
gs-4062	859	5	was	be	AUX
gs-4062	859	6	instrumental	instrumental	ADJ
gs-4062	859	7	in	in	ADP
gs-4062	859	8	guiding	guide	VERB
gs-4062	859	9	the	the	DET
gs-4062	859	10	field	field	NOUN
gs-4062	859	11	towards	towards	ADP
gs-4062	859	12	combination	combination	NOUN
gs-4062	859	13	bnab	bnab	NOUN
gs-4062	859	14	therapy	therapy	NOUN
gs-4062	859	15	,	,	PUNCT
gs-4062	859	16	which	which	PRON
gs-4062	859	17	has	have	AUX
gs-4062	859	18	yielded	yield	VERB
gs-4062	859	19	far	far	ADV
gs-4062	859	20	more	more	ADV
gs-4062	859	21	promising	promising	ADJ
gs-4062	859	22	results	result	NOUN
gs-4062	859	23	.	.	PUNCT
gs-4062	860	1	the	the	DET
gs-4062	860	2	discussion	discussion	NOUN
gs-4062	860	3	around	around	ADP
gs-4062	860	4	bnabs	bnab	NOUN
gs-4062	860	5	is	be	AUX
gs-4062	860	6	multifaceted	multifacete	VERB
gs-4062	860	7	,	,	PUNCT
gs-4062	860	8	encompassing	encompass	VERB
gs-4062	860	9	their	their	PRON
gs-4062	860	10	role	role	NOUN
gs-4062	860	11	in	in	ADP
gs-4062	860	12	treatment	treatment	NOUN
gs-4062	860	13	,	,	PUNCT
gs-4062	860	14	prevention	prevention	NOUN
gs-4062	860	15	,	,	PUNCT
gs-4062	860	16	and	and	CCONJ
gs-4062	860	17	most	most	ADV
gs-4062	860	18	intriguingly	intriguingly	ADV
gs-4062	860	19	,	,	PUNCT
gs-4062	860	20	cure	cure	NOUN
gs-4062	860	21	strategies	strategy	NOUN
gs-4062	860	22	.	.	PUNCT
gs-4062	861	1	for	for	ADP
gs-4062	861	2	treatment	treatment	NOUN
gs-4062	861	3	,	,	PUNCT
gs-4062	861	4	combination	combination	NOUN
gs-4062	861	5	bnab	bnab	NOUN
gs-4062	861	6	infusions	infusion	NOUN
gs-4062	861	7	offer	offer	VERB
gs-4062	861	8	the	the	DET
gs-4062	861	9	potential	potential	NOUN
gs-4062	861	10	for	for	ADP
gs-4062	861	11	extended	extended	ADJ
gs-4062	861	12	periods	period	NOUN
gs-4062	861	13	of	of	ADP
gs-4062	861	14	virological	virological	ADJ
gs-4062	861	15	suppression	suppression	NOUN
gs-4062	861	16	without	without	ADP
gs-4062	861	17	the	the	DET
gs-4062	861	18	need	need	NOUN
gs-4062	861	19	for	for	ADP
gs-4062	861	20	daily	daily	ADJ
gs-4062	861	21	pills	pill	NOUN
gs-4062	861	22	or	or	CCONJ
gs-4062	861	23	even	even	ADV
gs-4062	861	24	periodic	periodic	ADJ
gs-4062	861	25	injections	injection	NOUN
gs-4062	861	26	,	,	PUNCT
gs-4062	861	27	appealing	appeal	VERB
gs-4062	861	28	to	to	ADP
gs-4062	861	29	a	a	DET
gs-4062	861	30	subset	subset	NOUN
gs-4062	861	31	of	of	ADP
gs-4062	861	32	patients	patient	NOUN
gs-4062	861	33	who	who	PRON
gs-4062	861	34	desire	desire	VERB
gs-4062	861	35	even	even	ADV
gs-4062	861	36	less	less	ADV
gs-4062	861	37	frequent	frequent	ADJ
gs-4062	861	38	healthcare	healthcare	NOUN
gs-4062	861	39	engagements	engagement	NOUN
gs-4062	861	40	.	.	PUNCT
gs-4062	862	1	however	however	ADV
gs-4062	862	2	,	,	PUNCT
gs-4062	862	3	their	their	PRON
gs-4062	862	4	utility	utility	NOUN
gs-4062	862	5	is	be	AUX
gs-4062	862	6	currently	currently	ADV
gs-4062	862	7	limited	limit	VERB
gs-4062	862	8	by	by	ADP
gs-4062	862	9	the	the	DET
gs-4062	862	10	necessity	necessity	NOUN
gs-4062	862	11	for	for	ADP
gs-4062	862	12	pre	pre	VERB
gs-4062	862	13	-	-	NOUN
gs-4062	862	14	screening	screen	VERB
gs-4062	862	15	to	to	PART
gs-4062	862	16	ensure	ensure	VERB
gs-4062	862	17	the	the	DET
gs-4062	862	18	patient	patient	NOUN
gs-4062	862	19	’s	’s	PART
gs-4062	862	20	virus	virus	NOUN
gs-4062	862	21	is	be	AUX
gs-4062	862	22	sensitive	sensitive	ADJ
gs-4062	862	23	to	to	ADP
gs-4062	862	24	the	the	DET
gs-4062	862	25	specific	specific	ADJ
gs-4062	862	26	bnabs	bnab	NOUN
gs-4062	862	27	being	be	AUX
gs-4062	862	28	used	use	VERB
gs-4062	862	29	.	.	PUNCT
gs-4062	863	1	this	this	PRON
gs-4062	863	2	adds	add	VERB
gs-4062	863	3	a	a	DET
gs-4062	863	4	layer	layer	NOUN
gs-4062	863	5	of	of	ADP
gs-4062	863	6	complexity	complexity	NOUN
gs-4062	863	7	and	and	CCONJ
gs-4062	863	8	cost	cost	NOUN
gs-4062	863	9	,	,	PUNCT
gs-4062	863	10	confining	confine	VERB
gs-4062	863	11	their	their	PRON
gs-4062	863	12	use	use	NOUN
gs-4062	863	13	to	to	ADP
gs-4062	863	14	more	more	ADJ
gs-4062	863	15	specialized	specialized	ADJ
gs-4062	863	16	settings	setting	NOUN
gs-4062	863	17	for	for	ADP
gs-4062	863	18	the	the	DET
gs-4062	863	19	foreseeable	foreseeable	ADJ
gs-4062	863	20	future	future	NOUN
gs-4062	863	21	.	.	PUNCT
gs-4062	864	1	in	in	ADP
gs-4062	864	2	prevention	prevention	NOUN
gs-4062	864	3	,	,	PUNCT
gs-4062	864	4	bnabs	bnab	NOUN
gs-4062	864	5	offer	offer	VERB
gs-4062	864	6	a	a	DET
gs-4062	864	7	powerful	powerful	ADJ
gs-4062	864	8	alternative	alternative	NOUN
gs-4062	864	9	to	to	ADP
gs-4062	864	10	oral	oral	ADJ
gs-4062	864	11	and	and	CCONJ
gs-4062	864	12	injectable	injectable	ADJ
gs-4062	864	13	prep	prep	NOUN
gs-4062	864	14	.	.	PUNCT
gs-4062	865	1	their	their	PRON
gs-4062	865	2	high	high	ADJ
gs-4062	865	3	potency	potency	NOUN
gs-4062	865	4	and	and	CCONJ
gs-4062	865	5	long	long	ADJ
gs-4062	865	6	half	half	ADJ
gs-4062	865	7	-	-	PUNCT
gs-4062	865	8	life	life	NOUN
gs-4062	865	9	could	could	AUX
gs-4062	865	10	provide	provide	VERB
gs-4062	865	11	months	month	NOUN
gs-4062	865	12	of	of	ADP
gs-4062	865	13	protection	protection	NOUN
gs-4062	865	14	after	after	ADP
gs-4062	865	15	a	a	DET
gs-4062	865	16	single	single	ADJ
gs-4062	865	17	infusion	infusion	NOUN
gs-4062	865	18	.	.	PUNCT
gs-4062	866	1	however	however	ADV
gs-4062	866	2	,	,	PUNCT
gs-4062	866	3	the	the	DET
gs-4062	866	4	same	same	ADJ
gs-4062	866	5	issue	issue	NOUN
gs-4062	866	6	of	of	ADP
gs-4062	866	7	viral	viral	ADJ
gs-4062	866	8	sensitivity	sensitivity	NOUN
gs-4062	866	9	applies	apply	VERB
gs-4062	866	10	.	.	PUNCT
gs-4062	867	1	for	for	SCONJ
gs-4062	867	2	bnab	bnab	NOUN
gs-4062	867	3	-	-	PUNCT
gs-4062	867	4	based	base	VERB
gs-4062	867	5	prep	prep	NOUN
gs-4062	867	6	to	to	PART
gs-4062	867	7	be	be	AUX
gs-4062	867	8	a	a	DET
gs-4062	867	9	global	global	ADJ
gs-4062	867	10	tool	tool	NOUN
gs-4062	867	11	,	,	PUNCT
gs-4062	867	12	a	a	DET
gs-4062	867	13	cocktail	cocktail	NOUN
gs-4062	867	14	would	would	AUX
gs-4062	867	15	be	be	AUX
gs-4062	867	16	needed	need	VERB
gs-4062	867	17	that	that	PRON
gs-4062	867	18	neutralizes	neutralize	VERB
gs-4062	867	19	a	a	DET
gs-4062	867	20	vast	vast	ADJ
gs-4062	867	21	majority	majority	NOUN
gs-4062	867	22	of	of	ADP
gs-4062	867	23	circulating	circulate	VERB
gs-4062	867	24	strains	strain	NOUN
gs-4062	867	25	,	,	PUNCT
gs-4062	867	26	a	a	DET
gs-4062	867	27	tall	tall	ADJ
gs-4062	867	28	order	order	NOUN
gs-4062	867	29	given	give	VERB
gs-4062	867	30	the	the	DET
gs-4062	867	31	immense	immense	ADJ
gs-4062	867	32	diversity	diversity	NOUN
gs-4062	867	33	of	of	ADP
gs-4062	867	34	hiv	hiv	PROPN
gs-4062	867	35	.	.	PUNCT
gs-4062	868	1	the	the	DET
gs-4062	868	2	most	most	ADV
gs-4062	868	3	exciting	exciting	ADJ
gs-4062	868	4	discussion	discussion	NOUN
gs-4062	868	5	surrounds	surround	VERB
gs-4062	868	6	their	their	PRON
gs-4062	868	7	application	application	NOUN
gs-4062	868	8	in	in	ADP
gs-4062	868	9	cure	cure	NOUN
gs-4062	868	10	research	research	NOUN
gs-4062	868	11	.	.	PUNCT
gs-4062	869	1	the	the	DET
gs-4062	869	2	"	"	PUNCT
gs-4062	869	3	kick	kick	VERB
gs-4062	869	4	and	and	CCONJ
gs-4062	869	5	kill	kill	VERB
gs-4062	869	6	"	"	PUNCT
gs-4062	869	7	strategy	strategy	NOUN
gs-4062	869	8	aims	aim	VERB
gs-4062	869	9	to	to	PART
gs-4062	869	10	first	first	ADV
gs-4062	869	11	activate	activate	VERB
gs-4062	869	12	the	the	DET
gs-4062	869	13	latent	latent	PROPN
gs-4062	869	14	reservoir	reservoir	NOUN
gs-4062	869	15	(	(	PUNCT
gs-4062	869	16	"	"	PUNCT
gs-4062	869	17	kick	kick	VERB
gs-4062	869	18	"	"	PUNCT
gs-4062	869	19	)	)	PUNCT
gs-4062	869	20	and	and	CCONJ
gs-4062	869	21	then	then	ADV
gs-4062	869	22	eliminate	eliminate	VERB
gs-4062	869	23	the	the	DET
gs-4062	869	24	cells	cell	NOUN
gs-4062	869	25	that	that	PRON
gs-4062	869	26	express	express	VERB
gs-4062	869	27	viral	viral	ADJ
gs-4062	869	28	antigens	antigen	NOUN
gs-4062	869	29	(	(	PUNCT
gs-4062	869	30	"	"	PUNCT
gs-4062	869	31	kill	kill	VERB
gs-4062	869	32	"	"	PUNCT
gs-4062	869	33	)	)	PUNCT
gs-4062	869	34	.	.	PUNCT
gs-4062	870	1	bnabs	bnab	NOUN
gs-4062	870	2	are	be	AUX
gs-4062	870	3	ideal	ideal	ADJ
gs-4062	870	4	candidates	candidate	NOUN
gs-4062	870	5	for	for	ADP
gs-4062	870	6	the	the	DET
gs-4062	870	7	"	"	PUNCT
gs-4062	870	8	kill	kill	NOUN
gs-4062	870	9	"	"	PUNCT
gs-4062	870	10	component	component	NOUN
gs-4062	870	11	.	.	PUNCT
gs-4062	871	1	by	by	ADP
gs-4062	871	2	binding	bind	VERB
gs-4062	871	3	to	to	ADP
gs-4062	871	4	hiv	hiv	PROPN
gs-4062	871	5	envelope	envelope	NOUN
gs-4062	871	6	proteins	protein	NOUN
gs-4062	871	7	expressed	express	VERB
gs-4062	871	8	on	on	ADP
gs-4062	871	9	the	the	DET
gs-4062	871	10	surface	surface	NOUN
gs-4062	871	11	of	of	ADP
gs-4062	871	12	a	a	DET
gs-4062	871	13	reactivated	reactivated	ADJ
gs-4062	871	14	cell	cell	NOUN
gs-4062	871	15	,	,	PUNCT
gs-4062	871	16	they	they	PRON
gs-4062	871	17	flag	flag	VERB
gs-4062	871	18	it	it	PRON
gs-4062	871	19	for	for	ADP
gs-4062	871	20	destruction	destruction	NOUN
gs-4062	871	21	by	by	ADP
gs-4062	871	22	the	the	DET
gs-4062	871	23	immune	immune	ADJ
gs-4062	871	24	system	system	NOUN
gs-4062	871	25	,	,	PUNCT
gs-4062	871	26	specifically	specifically	ADV
gs-4062	871	27	through	through	ADP
gs-4062	871	28	a	a	DET
gs-4062	871	29	process	process	NOUN
gs-4062	871	30	called	call	VERB
gs-4062	871	31	antibody	antibody	NOUN
gs-4062	871	32	-	-	PUNCT
gs-4062	871	33	dependent	dependent	ADJ
gs-4062	871	34	cellular	cellular	ADJ
gs-4062	871	35	cytotoxicity	cytotoxicity	NOUN
gs-4062	871	36	(	(	PUNCT
gs-4062	871	37	adcc	adcc	NOUN
gs-4062	871	38	)	)	PUNCT
gs-4062	871	39	.	.	PUNCT
gs-4062	872	1	early	early	ADJ
gs-4062	872	2	-	-	PUNCT
gs-4062	872	3	phase	phase	NOUN
gs-4062	872	4	clinical	clinical	ADJ
gs-4062	872	5	trials	trial	NOUN
gs-4062	872	6	combining	combine	VERB
gs-4062	872	7	bnabs	bnab	NOUN
gs-4062	872	8	with	with	ADP
gs-4062	872	9	latency	latency	NOUN
gs-4062	872	10	-	-	PUNCT
gs-4062	872	11	reversing	reverse	VERB
gs-4062	872	12	agents	agent	NOUN
gs-4062	872	13	have	have	AUX
gs-4062	872	14	shown	show	VERB
gs-4062	872	15	a	a	DET
gs-4062	872	16	measurable	measurable	NOUN
gs-4062	872	17	,	,	PUNCT
gs-4062	872	18	though	though	SCONJ
gs-4062	872	19	modest	modest	ADJ
gs-4062	872	20	,	,	PUNCT
gs-4062	872	21	reduction	reduction	NOUN
gs-4062	872	22	in	in	ADP
gs-4062	872	23	the	the	DET
gs-4062	872	24	size	size	NOUN
gs-4062	872	25	of	of	ADP
gs-4062	872	26	the	the	DET
gs-4062	872	27	reservoir	reservoir	NOUN
gs-4062	872	28	.	.	PUNCT
gs-4062	873	1	this	this	PRON
gs-4062	873	2	is	be	AUX
gs-4062	873	3	a	a	DET
gs-4062	873	4	proof	proof	NOUN
gs-4062	873	5	-	-	PUNCT
gs-4062	873	6	of	of	ADP
gs-4062	873	7	-	-	PUNCT
gs-4062	873	8	concept	concept	NOUN
gs-4062	873	9	that	that	SCONJ
gs-4062	873	10	the	the	DET
gs-4062	873	11	immune	immune	ADJ
gs-4062	873	12	system	system	NOUN
gs-4062	873	13	can	can	AUX
gs-4062	873	14	be	be	AUX
gs-4062	873	15	harnessed	harness	VERB
gs-4062	873	16	to	to	ADP
gs-4062	873	17	clear	clear	ADJ
gs-4062	873	18	infection	infection	NOUN
gs-4062	873	19	.	.	PUNCT
gs-4062	874	1	the	the	DET
gs-4062	874	2	discussion	discussion	NOUN
gs-4062	874	3	now	now	ADV
gs-4062	874	4	focuses	focus	VERB
gs-4062	874	5	on	on	ADP
gs-4062	874	6	how	how	SCONJ
gs-4062	874	7	to	to	PART
gs-4062	874	8	improve	improve	VERB
gs-4062	874	9	this	this	DET
gs-4062	874	10	approach	approach	NOUN
gs-4062	874	11	:	:	PUNCT
gs-4062	874	12	finding	find	VERB
gs-4062	874	13	more	more	ADV
gs-4062	874	14	potent	potent	ADJ
gs-4062	874	15	and	and	CCONJ
gs-4062	874	16	broader	broad	ADJ
gs-4062	874	17	latency	latency	NOUN
gs-4062	874	18	-	-	PUNCT
gs-4062	874	19	reversing	reverse	VERB
gs-4062	874	20	agents	agent	NOUN
gs-4062	874	21	,	,	PUNCT
gs-4062	874	22	designing	design	VERB
gs-4062	874	23	bnabs	bnab	NOUN
gs-4062	874	24	with	with	ADP
gs-4062	874	25	enhanced	enhanced	ADJ
gs-4062	874	26	effector	effector	NOUN
gs-4062	874	27	functions	function	NOUN
gs-4062	874	28	to	to	PART
gs-4062	874	29	better	well	ADJ
gs-4062	874	30	recruit	recruit	NOUN
gs-4062	874	31	killer	killer	NOUN
gs-4062	874	32	cells	cell	NOUN
gs-4062	874	33	,	,	PUNCT
gs-4062	874	34	and	and	CCONJ
gs-4062	874	35	combining	combine	VERB
gs-4062	874	36	bnabs	bnab	NOUN
gs-4062	874	37	with	with	ADP
gs-4062	874	38	other	other	ADJ
gs-4062	874	39	immune	immune	ADJ
gs-4062	874	40	modulators	modulator	NOUN
gs-4062	874	41	like	like	ADP
gs-4062	874	42	therapeutic	therapeutic	ADJ
gs-4062	874	43	vaccines	vaccine	NOUN
gs-4062	874	44	.	.	PUNCT
gs-4062	875	1	while	while	SCONJ
gs-4062	875	2	a	a	DET
gs-4062	875	3	cure	cure	NOUN
gs-4062	875	4	remains	remain	VERB
gs-4062	875	5	elusive	elusive	ADJ
gs-4062	875	6	,	,	PUNCT
gs-4062	875	7	bnabs	bnab	NOUN
gs-4062	875	8	have	have	AUX
gs-4062	875	9	provided	provide	VERB
gs-4062	875	10	a	a	DET
gs-4062	875	11	critical	critical	ADJ
gs-4062	875	12	tool	tool	NOUN
gs-4062	875	13	and	and	CCONJ
gs-4062	875	14	a	a	DET
gs-4062	875	15	glimmer	glimmer	NOUN
gs-4062	875	16	of	of	ADP
gs-4062	875	17	hope	hope	NOUN
gs-4062	875	18	that	that	SCONJ
gs-4062	875	19	a	a	DET
gs-4062	875	20	functional	functional	ADJ
gs-4062	875	21	cure	cure	NOUN
gs-4062	875	22	—	—	PUNCT
gs-4062	875	23	long	long	ADJ
gs-4062	875	24	-	-	PUNCT
gs-4062	875	25	term	term	NOUN
gs-4062	875	26	control	control	NOUN
gs-4062	875	27	of	of	ADP
gs-4062	875	28	the	the	DET
gs-4062	875	29	virus	virus	NOUN
gs-4062	875	30	without	without	ADP
gs-4062	875	31	art	art	NOUN
gs-4062	875	32	—	—	PUNCT
gs-4062	875	33	may	may	AUX
gs-4062	875	34	one	one	NUM
gs-4062	875	35	day	day	NOUN
gs-4062	875	36	be	be	AUX
gs-4062	875	37	possible	possible	ADJ
gs-4062	875	38	.	.	PUNCT
gs-4062	876	1	confronting	confront	VERB
gs-4062	876	2	the	the	DET
gs-4062	876	3	elephant	elephant	NOUN
gs-4062	876	4	in	in	ADP
gs-4062	876	5	the	the	DET
gs-4062	876	6	room	room	NOUN
gs-4062	876	7	:	:	PUNCT
gs-4062	876	8	the	the	DET
gs-4062	876	9	chasm	chasm	NOUN
gs-4062	876	10	of	of	ADP
gs-4062	876	11	global	global	ADJ
gs-4062	876	12	equity	equity	NOUN
gs-4062	876	13	no	no	DET
gs-4062	876	14	discussion	discussion	NOUN
gs-4062	876	15	of	of	ADP
gs-4062	876	16	these	these	DET
gs-4062	876	17	magnificent	magnificent	ADJ
gs-4062	876	18	scientific	scientific	ADJ
gs-4062	876	19	advances	advance	NOUN
gs-4062	876	20	is	be	AUX
gs-4062	876	21	morally	morally	ADV
gs-4062	876	22	or	or	CCONJ
gs-4062	876	23	practically	practically	ADV
gs-4062	876	24	complete	complete	ADJ
gs-4062	876	25	without	without	ADP
gs-4062	876	26	a	a	DET
gs-4062	876	27	sober	sober	ADJ
gs-4062	876	28	and	and	CCONJ
gs-4062	876	29	urgent	urgent	ADJ
gs-4062	876	30	address	address	NOUN
gs-4062	876	31	of	of	ADP
gs-4062	876	32	the	the	DET
gs-4062	876	33	devastating	devastating	ADJ
gs-4062	876	34	inequity	inequity	NOUN
gs-4062	876	35	in	in	ADP
gs-4062	876	36	global	global	ADJ
gs-4062	876	37	access	access	NOUN
gs-4062	876	38	.	.	PUNCT
gs-4062	877	1	the	the	DET
gs-4062	877	2	brilliant	brilliant	ADJ
gs-4062	877	3	promise	promise	NOUN
gs-4062	877	4	of	of	ADP
gs-4062	877	5	long	long	ADV
gs-4062	877	6	-	-	PUNCT
gs-4062	877	7	acting	act	VERB
gs-4062	877	8	injectables	injectable	NOUN
gs-4062	877	9	,	,	PUNCT
gs-4062	877	10	novel	novel	ADJ
gs-4062	877	11	agents	agent	NOUN
gs-4062	877	12	like	like	ADP
gs-4062	877	13	lenacapavir	lenacapavir	NOUN
gs-4062	877	14	,	,	PUNCT
gs-4062	877	15	and	and	CCONJ
gs-4062	877	16	cutting	cut	VERB
gs-4062	877	17	-	-	PUNCT
gs-4062	877	18	edge	edge	NOUN
gs-4062	877	19	immunotherapies	immunotherapy	NOUN
gs-4062	877	20	stands	stand	VERB
gs-4062	877	21	in	in	ADP
gs-4062	877	22	stark	stark	ADJ
gs-4062	877	23	,	,	PUNCT
gs-4062	877	24	shameful	shameful	ADJ
gs-4062	877	25	contrast	contrast	NOUN
gs-4062	877	26	to	to	ADP
gs-4062	877	27	the	the	DET
gs-4062	877	28	reality	reality	NOUN
gs-4062	877	29	on	on	ADP
gs-4062	877	30	the	the	DET
gs-4062	877	31	ground	ground	NOUN
gs-4062	877	32	in	in	ADP
gs-4062	877	33	many	many	ADJ
gs-4062	877	34	lowand	lowand	ADJ
gs-4062	877	35	middle	middle	ADJ
gs-4062	877	36	-	-	PUNCT
gs-4062	877	37	income	income	NOUN
gs-4062	877	38	countries	country	NOUN
gs-4062	877	39	(	(	PUNCT
gs-4062	877	40	lmics	lmic	NOUN
gs-4062	877	41	)	)	PUNCT
gs-4062	877	42	.	.	PUNCT
gs-4062	878	1	while	while	SCONJ
gs-4062	878	2	high	high	ADJ
gs-4062	878	3	-	-	PUNCT
gs-4062	878	4	income	income	NOUN
gs-4062	878	5	countries	country	NOUN
gs-4062	878	6	debate	debate	VERB
gs-4062	878	7	the	the	DET
gs-4062	878	8	nuances	nuance	NOUN
gs-4062	878	9	of	of	ADP
gs-4062	878	10	weight	weight	NOUN
gs-4062	878	11	gain	gain	NOUN
gs-4062	878	12	and	and	CCONJ
gs-4062	878	13	injection	injection	NOUN
gs-4062	878	14	schedules	schedule	NOUN
gs-4062	878	15	,	,	PUNCT
gs-4062	878	16	many	many	ADJ
gs-4062	878	17	public	public	ADJ
gs-4062	878	18	health	health	NOUN
gs-4062	878	19	clinics	clinic	NOUN
gs-4062	878	20	in	in	ADP
gs-4062	878	21	sub	sub	ADJ
gs-4062	878	22	-	-	ADJ
gs-4062	878	23	saharan	saharan	ADJ
gs-4062	878	24	africa	africa	PROPN
gs-4062	878	25	still	still	ADV
gs-4062	878	26	struggle	struggle	VERB
gs-4062	878	27	with	with	ADP
gs-4062	878	28	stockouts	stockout	NOUN
gs-4062	878	29	of	of	ADP
gs-4062	878	30	basic	basic	ADJ
gs-4062	878	31	dolutegravirbased	dolutegravirbase	VERB
gs-4062	878	32	regimens	regimen	NOUN
gs-4062	878	33	and	and	CCONJ
gs-4062	878	34	lack	lack	VERB
gs-4062	878	35	the	the	DET
gs-4062	878	36	capacity	capacity	NOUN
gs-4062	878	37	for	for	ADP
gs-4062	878	38	routine	routine	ADJ
gs-4062	878	39	viral	viral	ADJ
gs-4062	878	40	load	load	NOUN
gs-4062	878	41	monitoring	monitoring	NOUN
gs-4062	878	42	.	.	PUNCT
gs-4062	879	1	this	this	DET
gs-4062	879	2	inequity	inequity	NOUN
gs-4062	879	3	is	be	AUX
gs-4062	879	4	driven	drive	VERB
gs-4062	879	5	by	by	ADP
gs-4062	879	6	a	a	DET
gs-4062	879	7	familiar	familiar	ADJ
gs-4062	879	8	triad	triad	NOUN
gs-4062	879	9	of	of	ADP
gs-4062	879	10	barriers	barrier	NOUN
gs-4062	879	11	:	:	PUNCT
gs-4062	879	12	cost	cost	NOUN
gs-4062	879	13	,	,	PUNCT
gs-4062	879	14	infrastructure	infrastructure	NOUN
gs-4062	879	15	,	,	PUNCT
gs-4062	879	16	and	and	CCONJ
gs-4062	879	17	intellectual	intellectual	ADJ
gs-4062	879	18	property	property	NOUN
gs-4062	879	19	.	.	PUNCT
gs-4062	880	1	the	the	DET
gs-4062	880	2	current	current	ADJ
gs-4062	880	3	pricing	pricing	NOUN
gs-4062	880	4	of	of	ADP
gs-4062	880	5	these	these	DET
gs-4062	880	6	novel	novel	ADJ
gs-4062	880	7	therapies	therapy	NOUN
gs-4062	880	8	places	place	VERB
gs-4062	880	9	them	they	PRON
gs-4062	880	10	far	far	ADV
gs-4062	880	11	beyond	beyond	ADP
gs-4062	880	12	the	the	DET
gs-4062	880	13	reach	reach	NOUN
gs-4062	880	14	of	of	ADP
gs-4062	880	15	lmic	lmic	ADJ
gs-4062	880	16	georgian	georgian	NOUN
gs-4062	880	17	scientists/	scientists/	NUM
gs-4062	880	18	.	.	PUNCT
gs-4062	881	1	7	7	NUM
gs-4062	881	2	n	n	PRON
gs-4062	881	3	3	3	NUM
gs-4062	881	4	,	,	PUNCT
gs-4062	881	5	2025	2025	NUM
gs-4062	881	6	559	559	NUM
gs-4062	881	7	health	health	NOUN
gs-4062	881	8	budgets	budget	NOUN
gs-4062	881	9	.	.	PUNCT
gs-4062	882	1	the	the	DET
gs-4062	882	2	infrastructure	infrastructure	NOUN
gs-4062	882	3	required	require	VERB
gs-4062	882	4	for	for	ADP
gs-4062	882	5	la	la	ADJ
gs-4062	882	6	-	-	NOUN
gs-4062	882	7	art	art	NOUN
gs-4062	882	8	—	—	PUNCT
gs-4062	882	9	reliable	reliable	ADJ
gs-4062	882	10	refrigeration	refrigeration	NOUN
gs-4062	882	11	,	,	PUNCT
gs-4062	882	12	trained	train	VERB
gs-4062	882	13	nursing	nursing	NOUN
gs-4062	882	14	staff	staff	NOUN
gs-4062	882	15	,	,	PUNCT
gs-4062	882	16	robust	robust	ADJ
gs-4062	882	17	patient	patient	ADJ
gs-4062	882	18	tracking	tracking	NOUN
gs-4062	882	19	systems	system	NOUN
gs-4062	882	20	—	—	PUNCT
gs-4062	882	21	is	be	AUX
gs-4062	882	22	often	often	ADV
gs-4062	882	23	absent	absent	ADJ
gs-4062	882	24	in	in	ADP
gs-4062	882	25	resource	resource	NOUN
gs-4062	882	26	-	-	PUNCT
gs-4062	882	27	constrained	constrain	VERB
gs-4062	882	28	settings	setting	NOUN
gs-4062	882	29	.	.	PUNCT
gs-4062	883	1	lastly	lastly	ADV
gs-4062	883	2	,	,	PUNCT
gs-4062	883	3	stringent	stringent	ADJ
gs-4062	883	4	patent	patent	NOUN
gs-4062	883	5	protections	protection	NOUN
gs-4062	883	6	prevent	prevent	VERB
gs-4062	883	7	the	the	DET
gs-4062	883	8	manufacture	manufacture	NOUN
gs-4062	883	9	of	of	ADP
gs-4062	883	10	affordable	affordable	ADJ
gs-4062	883	11	generic	generic	ADJ
gs-4062	883	12	versions	version	NOUN
gs-4062	883	13	for	for	ADP
gs-4062	883	14	years	year	NOUN
gs-4062	883	15	to	to	PART
gs-4062	883	16	come	come	VERB
gs-4062	883	17	.	.	PUNCT
gs-4062	884	1	the	the	DET
gs-4062	884	2	discussion	discussion	NOUN
gs-4062	884	3	must	must	AUX
gs-4062	884	4	vehemently	vehemently	ADV
gs-4062	884	5	argue	argue	VERB
gs-4062	884	6	that	that	SCONJ
gs-4062	884	7	this	this	PRON
gs-4062	884	8	is	be	AUX
gs-4062	884	9	not	not	PART
gs-4062	884	10	merely	merely	ADV
gs-4062	884	11	an	an	DET
gs-4062	884	12	ethical	ethical	ADJ
gs-4062	884	13	failing	failing	NOUN
gs-4062	884	14	but	but	CCONJ
gs-4062	884	15	a	a	DET
gs-4062	884	16	profound	profound	ADJ
gs-4062	884	17	strategic	strategic	ADJ
gs-4062	884	18	error	error	NOUN
gs-4062	884	19	that	that	PRON
gs-4062	884	20	threatens	threaten	VERB
gs-4062	884	21	global	global	ADJ
gs-4062	884	22	health	health	NOUN
gs-4062	884	23	security	security	NOUN
gs-4062	884	24	.	.	PUNCT
gs-4062	885	1	hiv	hiv	PROPN
gs-4062	885	2	does	do	AUX
gs-4062	885	3	not	not	PART
gs-4062	885	4	respect	respect	VERB
gs-4062	885	5	borders	border	NOUN
gs-4062	885	6	.	.	PUNCT
gs-4062	886	1	the	the	DET
gs-4062	886	2	unchecked	unchecked	ADJ
gs-4062	886	3	transmission	transmission	NOUN
gs-4062	886	4	of	of	ADP
gs-4062	886	5	the	the	DET
gs-4062	886	6	virus	virus	NOUN
gs-4062	886	7	in	in	ADP
gs-4062	886	8	regions	region	NOUN
gs-4062	886	9	without	without	ADP
gs-4062	886	10	access	access	NOUN
gs-4062	886	11	to	to	ADP
gs-4062	886	12	the	the	DET
gs-4062	886	13	most	most	ADV
gs-4062	886	14	effective	effective	ADJ
gs-4062	886	15	tools	tool	NOUN
gs-4062	886	16	creates	create	VERB
gs-4062	886	17	a	a	DET
gs-4062	886	18	larger	large	ADJ
gs-4062	886	19	pool	pool	NOUN
gs-4062	886	20	of	of	ADP
gs-4062	886	21	infection	infection	NOUN
gs-4062	886	22	,	,	PUNCT
gs-4062	886	23	increasing	increase	VERB
gs-4062	886	24	the	the	DET
gs-4062	886	25	probability	probability	NOUN
gs-4062	886	26	of	of	ADP
gs-4062	886	27	generating	generate	VERB
gs-4062	886	28	and	and	CCONJ
gs-4062	886	29	spreading	spread	VERB
gs-4062	886	30	drug	drug	NOUN
gs-4062	886	31	-	-	PUNCT
gs-4062	886	32	resistant	resistant	ADJ
gs-4062	886	33	strains	strain	NOUN
gs-4062	886	34	.	.	PUNCT
gs-4062	887	1	a	a	DET
gs-4062	887	2	resistant	resistant	ADJ
gs-4062	887	3	virus	virus	NOUN
gs-4062	887	4	that	that	PRON
gs-4062	887	5	emerges	emerge	VERB
gs-4062	887	6	in	in	ADP
gs-4062	887	7	one	one	NUM
gs-4062	887	8	part	part	NOUN
gs-4062	887	9	of	of	ADP
gs-4062	887	10	the	the	DET
gs-4062	887	11	world	world	NOUN
gs-4062	887	12	can	can	AUX
gs-4062	887	13	and	and	CCONJ
gs-4062	887	14	will	will	AUX
gs-4062	887	15	eventually	eventually	ADV
gs-4062	887	16	circulate	circulate	VERB
gs-4062	887	17	globally	globally	ADV
gs-4062	887	18	,	,	PUNCT
gs-4062	887	19	threatening	threaten	VERB
gs-4062	887	20	the	the	DET
gs-4062	887	21	efficacy	efficacy	NOUN
gs-4062	887	22	of	of	ADP
gs-4062	887	23	these	these	DET
gs-4062	887	24	same	same	ADJ
gs-4062	887	25	advanced	advanced	ADJ
gs-4062	887	26	drugs	drug	NOUN
gs-4062	887	27	in	in	ADP
gs-4062	887	28	wealthy	wealthy	ADJ
gs-4062	887	29	nations	nation	NOUN
gs-4062	887	30	.	.	PUNCT
gs-4062	888	1	therefore	therefore	ADV
gs-4062	888	2	,	,	PUNCT
gs-4062	888	3	ensuring	ensure	VERB
gs-4062	888	4	equitable	equitable	ADJ
gs-4062	888	5	access	access	NOUN
gs-4062	888	6	is	be	AUX
gs-4062	888	7	not	not	PART
gs-4062	888	8	an	an	DET
gs-4062	888	9	act	act	NOUN
gs-4062	888	10	of	of	ADP
gs-4062	888	11	charity	charity	NOUN
gs-4062	888	12	;	;	PUNCT
gs-4062	888	13	it	it	PRON
gs-4062	888	14	is	be	AUX
gs-4062	888	15	an	an	DET
gs-4062	888	16	act	act	NOUN
gs-4062	888	17	of	of	ADP
gs-4062	888	18	strategic	strategic	ADJ
gs-4062	888	19	self	self	NOUN
gs-4062	888	20	-	-	PUNCT
gs-4062	888	21	interest	interest	NOUN
gs-4062	888	22	.	.	PUNCT
gs-4062	889	1	the	the	DET
gs-4062	889	2	solutions	solution	NOUN
gs-4062	889	3	are	be	AUX
gs-4062	889	4	complex	complex	ADJ
gs-4062	889	5	but	but	CCONJ
gs-4062	889	6	necessary	necessary	ADJ
gs-4062	889	7	.	.	PUNCT
gs-4062	890	1	they	they	PRON
gs-4062	890	2	include	include	VERB
gs-4062	890	3	:	:	PUNCT
gs-4062	890	4	aggressive	aggressive	ADJ
gs-4062	890	5	voluntary	voluntary	ADJ
gs-4062	890	6	licensing	licensing	NOUN
gs-4062	890	7	:	:	PUNCT
gs-4062	890	8	pharmaceutical	pharmaceutical	ADJ
gs-4062	890	9	companies	company	NOUN
gs-4062	890	10	must	must	AUX
gs-4062	890	11	work	work	VERB
gs-4062	890	12	with	with	ADP
gs-4062	890	13	organizations	organization	NOUN
gs-4062	890	14	like	like	ADP
gs-4062	890	15	the	the	DET
gs-4062	890	16	medicines	medicine	NOUN
gs-4062	890	17	patent	patent	NOUN
gs-4062	890	18	pool	pool	NOUN
gs-4062	890	19	to	to	PART
gs-4062	890	20	negotiate	negotiate	VERB
gs-4062	890	21	voluntary	voluntary	ADJ
gs-4062	890	22	licenses	license	NOUN
gs-4062	890	23	for	for	ADP
gs-4062	890	24	generic	generic	ADJ
gs-4062	890	25	manufacture	manufacture	NOUN
gs-4062	890	26	of	of	ADP
gs-4062	890	27	new	new	ADJ
gs-4062	890	28	drugs	drug	NOUN
gs-4062	890	29	much	much	ADV
gs-4062	890	30	earlier	early	ADV
gs-4062	890	31	in	in	ADP
gs-4062	890	32	their	their	PRON
gs-4062	890	33	product	product	NOUN
gs-4062	890	34	life	life	NOUN
gs-4062	890	35	cycle	cycle	NOUN
gs-4062	890	36	.	.	PUNCT
gs-4062	891	1	tiered	tiere	VERB
gs-4062	891	2	pricing	pricing	NOUN
gs-4062	891	3	:	:	PUNCT
gs-4062	891	4	implementing	implement	VERB
gs-4062	891	5	fair	fair	ADJ
gs-4062	891	6	,	,	PUNCT
gs-4062	891	7	transparent	transparent	ADJ
gs-4062	891	8	,	,	PUNCT
gs-4062	891	9	and	and	CCONJ
gs-4062	891	10	drastic	drastic	ADJ
gs-4062	891	11	tiered	tiere	VERB
gs-4062	891	12	pricing	pricing	NOUN
gs-4062	891	13	models	model	NOUN
gs-4062	891	14	that	that	PRON
gs-4062	891	15	reflect	reflect	VERB
gs-4062	891	16	the	the	DET
gs-4062	891	17	economic	economic	ADJ
gs-4062	891	18	realities	reality	NOUN
gs-4062	891	19	of	of	ADP
gs-4062	891	20	different	different	ADJ
gs-4062	891	21	countries	country	NOUN
gs-4062	891	22	.	.	PUNCT
gs-4062	892	1	international	international	ADJ
gs-4062	892	2	funding	funding	NOUN
gs-4062	892	3	:	:	PUNCT
gs-4062	892	4	donor	donor	NOUN
gs-4062	892	5	governments	government	NOUN
gs-4062	892	6	and	and	CCONJ
gs-4062	892	7	organizations	organization	NOUN
gs-4062	892	8	must	must	AUX
gs-4062	892	9	increase	increase	VERB
gs-4062	892	10	funding	funding	NOUN
gs-4062	892	11	to	to	ADP
gs-4062	892	12	mechanisms	mechanism	NOUN
gs-4062	892	13	like	like	ADP
gs-4062	892	14	the	the	DET
gs-4062	892	15	global	global	ADJ
gs-4062	892	16	fund	fund	NOUN
gs-4062	892	17	to	to	PART
gs-4062	892	18	fight	fight	VERB
gs-4062	892	19	aids	aid	NOUN
gs-4062	892	20	,	,	PUNCT
gs-4062	892	21	tuberculosis	tuberculosis	NOUN
gs-4062	892	22	and	and	CCONJ
gs-4062	892	23	malaria	malaria	NOUN
gs-4062	892	24	to	to	PART
gs-4062	892	25	specifically	specifically	ADV
gs-4062	892	26	support	support	VERB
gs-4062	892	27	the	the	DET
gs-4062	892	28	introduction	introduction	NOUN
gs-4062	892	29	of	of	ADP
gs-4062	892	30	new	new	ADJ
gs-4062	892	31	technologies	technology	NOUN
gs-4062	892	32	.	.	PUNCT
gs-4062	893	1	technology	technology	NOUN
gs-4062	893	2	transfer	transfer	NOUN
gs-4062	893	3	and	and	CCONJ
gs-4062	893	4	infrastructure	infrastructure	NOUN
gs-4062	893	5	investment	investment	NOUN
gs-4062	893	6	:	:	PUNCT
gs-4062	893	7	supporting	support	VERB
gs-4062	893	8	programs	program	NOUN
gs-4062	893	9	that	that	PRON
gs-4062	893	10	build	build	VERB
gs-4062	893	11	the	the	DET
gs-4062	893	12	necessary	necessary	ADJ
gs-4062	893	13	laboratory	laboratory	NOUN
gs-4062	893	14	,	,	PUNCT
gs-4062	893	15	cold	cold	ADJ
gs-4062	893	16	chain	chain	NOUN
gs-4062	893	17	,	,	PUNCT
gs-4062	893	18	and	and	CCONJ
gs-4062	893	19	human	human	ADJ
gs-4062	893	20	resource	resource	NOUN
gs-4062	893	21	capacity	capacity	NOUN
gs-4062	893	22	in	in	ADP
gs-4062	893	23	lmics	lmic	NOUN
gs-4062	893	24	to	to	PART
gs-4062	893	25	deliver	deliver	VERB
gs-4062	893	26	these	these	DET
gs-4062	893	27	advanced	advanced	ADJ
gs-4062	893	28	therapies	therapy	NOUN
gs-4062	893	29	safely	safely	ADV
gs-4062	893	30	and	and	CCONJ
gs-4062	893	31	effectively	effectively	ADV
gs-4062	893	32	.	.	PUNCT
gs-4062	894	1	to	to	PART
gs-4062	894	2	discuss	discuss	VERB
gs-4062	894	3	the	the	DET
gs-4062	894	4	science	science	NOUN
gs-4062	894	5	without	without	ADP
gs-4062	894	6	dedicating	dedicate	VERB
gs-4062	894	7	equal	equal	ADJ
gs-4062	894	8	weight	weight	NOUN
gs-4062	894	9	to	to	ADP
gs-4062	894	10	the	the	DET
gs-4062	894	11	imperative	imperative	NOUN
gs-4062	894	12	of	of	ADP
gs-4062	894	13	equity	equity	NOUN
gs-4062	894	14	is	be	AUX
gs-4062	894	15	to	to	PART
gs-4062	894	16	tell	tell	VERB
gs-4062	894	17	only	only	ADV
gs-4062	894	18	half	half	DET
gs-4062	894	19	the	the	DET
gs-4062	894	20	story	story	NOUN
gs-4062	894	21	.	.	PUNCT
gs-4062	895	1	the	the	DET
gs-4062	895	2	scientific	scientific	ADJ
gs-4062	895	3	revolution	revolution	NOUN
gs-4062	895	4	will	will	AUX
gs-4062	895	5	be	be	AUX
gs-4062	895	6	a	a	DET
gs-4062	895	7	failure	failure	NOUN
gs-4062	895	8	if	if	SCONJ
gs-4062	895	9	its	its	PRON
gs-4062	895	10	benefits	benefit	NOUN
gs-4062	895	11	are	be	AUX
gs-4062	895	12	not	not	PART
gs-4062	895	13	shared	share	VERB
gs-4062	895	14	by	by	ADP
gs-4062	895	15	all	all	PRON
gs-4062	895	16	.	.	PUNCT
gs-4062	896	1	the	the	DET
gs-4062	896	2	future	future	NOUN
gs-4062	896	3	is	be	AUX
gs-4062	896	4	personalized	personalize	VERB
gs-4062	896	5	:	:	PUNCT
gs-4062	896	6	the	the	DET
gs-4062	896	7	role	role	NOUN
gs-4062	896	8	of	of	ADP
gs-4062	896	9	ai	ai	ADJ
gs-4062	896	10	and	and	CCONJ
gs-4062	896	11	advanced	advanced	ADJ
gs-4062	896	12	diagnostics	diagnostic	NOUN
gs-4062	896	13	the	the	DET
gs-4062	896	14	next	next	ADJ
gs-4062	896	15	frontier	frontier	NOUN
gs-4062	896	16	in	in	ADP
gs-4062	896	17	hiv	hiv	PROPN
gs-4062	896	18	medicine	medicine	NOUN
gs-4062	896	19	is	be	AUX
gs-4062	896	20	the	the	DET
gs-4062	896	21	move	move	NOUN
gs-4062	896	22	from	from	ADP
gs-4062	896	23	population	population	NOUN
gs-4062	896	24	-	-	PUNCT
gs-4062	896	25	based	base	VERB
gs-4062	896	26	guidelines	guideline	NOUN
gs-4062	896	27	to	to	PART
gs-4062	896	28	truly	truly	ADV
gs-4062	896	29	personalized	personalized	ADJ
gs-4062	896	30	care	care	NOUN
gs-4062	896	31	,	,	PUNCT
gs-4062	896	32	and	and	CCONJ
gs-4062	896	33	this	this	PRON
gs-4062	896	34	will	will	AUX
gs-4062	896	35	be	be	AUX
gs-4062	896	36	powered	power	VERB
gs-4062	896	37	by	by	ADP
gs-4062	896	38	artificial	artificial	ADJ
gs-4062	896	39	intelligence	intelligence	NOUN
gs-4062	896	40	and	and	CCONJ
gs-4062	896	41	advanced	advanced	ADJ
gs-4062	896	42	diagnostics	diagnostic	NOUN
gs-4062	896	43	.	.	PUNCT
gs-4062	897	1	the	the	DET
gs-4062	897	2	discussion	discussion	NOUN
gs-4062	897	3	around	around	ADP
gs-4062	897	4	weight	weight	NOUN
gs-4062	897	5	gain	gain	NOUN
gs-4062	897	6	has	have	AUX
gs-4062	897	7	already	already	ADV
gs-4062	897	8	highlighted	highlight	VERB
gs-4062	897	9	the	the	DET
gs-4062	897	10	role	role	NOUN
gs-4062	897	11	of	of	ADP
gs-4062	897	12	pharmacogenomics	pharmacogenomic	NOUN
gs-4062	897	13	;	;	PUNCT
gs-4062	897	14	certain	certain	ADJ
gs-4062	897	15	genetic	genetic	ADJ
gs-4062	897	16	polymorphisms	polymorphism	NOUN
gs-4062	897	17	can	can	AUX
gs-4062	897	18	predict	predict	VERB
gs-4062	897	19	an	an	DET
gs-4062	897	20	individual	individual	NOUN
gs-4062	897	21	's	's	PART
gs-4062	897	22	risk	risk	NOUN
gs-4062	897	23	of	of	ADP
gs-4062	897	24	gaining	gain	VERB
gs-4062	897	25	weight	weight	NOUN
gs-4062	897	26	on	on	ADP
gs-4062	897	27	an	an	DET
gs-4062	897	28	insti	insti	NOUN
gs-4062	897	29	.	.	PUNCT
gs-4062	898	1	this	this	PRON
gs-4062	898	2	is	be	AUX
gs-4062	898	3	just	just	ADV
gs-4062	898	4	the	the	DET
gs-4062	898	5	beginning	beginning	NOUN
gs-4062	898	6	.	.	PUNCT
gs-4062	899	1	conclusions	conclusion	NOUN
gs-4062	899	2	the	the	DET
gs-4062	899	3	comprehensive	comprehensive	ADJ
gs-4062	899	4	investigation	investigation	NOUN
gs-4062	899	5	into	into	ADP
gs-4062	899	6	the	the	DET
gs-4062	899	7	current	current	ADJ
gs-4062	899	8	and	and	CCONJ
gs-4062	899	9	emerging	emerge	VERB
gs-4062	899	10	landscape	landscape	NOUN
gs-4062	899	11	of	of	ADP
gs-4062	899	12	antiretroviral	antiretroviral	ADJ
gs-4062	899	13	therapy	therapy	NOUN
gs-4062	899	14	culminates	culminate	VERB
gs-4062	899	15	in	in	ADP
gs-4062	899	16	a	a	DET
gs-4062	899	17	series	series	NOUN
gs-4062	899	18	of	of	ADP
gs-4062	899	19	definitive	definitive	ADJ
gs-4062	899	20	and	and	CCONJ
gs-4062	899	21	forward	forward	ADV
gs-4062	899	22	-	-	PUNCT
gs-4062	899	23	looking	look	VERB
gs-4062	899	24	conclusions	conclusion	NOUN
gs-4062	899	25	.	.	PUNCT
gs-4062	900	1	this	this	DET
gs-4062	900	2	analysis	analysis	NOUN
gs-4062	900	3	,	,	PUNCT
gs-4062	900	4	spanning	span	VERB
gs-4062	900	5	the	the	DET
gs-4062	900	6	molecular	molecular	ADJ
gs-4062	900	7	mechanisms	mechanism	NOUN
gs-4062	900	8	of	of	ADP
gs-4062	900	9	novel	novel	ADJ
gs-4062	900	10	agents	agent	NOUN
gs-4062	900	11	to	to	ADP
gs-4062	900	12	their	their	PRON
gs-4062	900	13	global	global	ADJ
gs-4062	900	14	implementation	implementation	NOUN
gs-4062	900	15	,	,	PUNCT
gs-4062	900	16	affirms	affirm	VERB
gs-4062	900	17	that	that	SCONJ
gs-4062	900	18	the	the	DET
gs-4062	900	19	field	field	NOUN
gs-4062	900	20	of	of	ADP
gs-4062	900	21	hiv	hiv	PROPN
gs-4062	900	22	management	management	NOUN
gs-4062	900	23	has	have	AUX
gs-4062	900	24	irrevocably	irrevocably	ADV
gs-4062	900	25	transcended	transcend	VERB
gs-4062	900	26	its	its	PRON
gs-4062	900	27	original	original	ADJ
gs-4062	900	28	goal	goal	NOUN
gs-4062	900	29	of	of	ADP
gs-4062	900	30	mere	mere	ADJ
gs-4062	900	31	survival	survival	NOUN
gs-4062	900	32	.	.	PUNCT
gs-4062	901	1	the	the	DET
gs-4062	901	2	era	era	NOUN
gs-4062	901	3	of	of	ADP
gs-4062	901	4	toxic	toxic	ADJ
gs-4062	901	5	,	,	PUNCT
gs-4062	901	6	cumbersome	cumbersome	ADJ
gs-4062	901	7	,	,	PUNCT
gs-4062	901	8	and	and	CCONJ
gs-4062	901	9	psychologically	psychologically	ADV
gs-4062	901	10	burdensome	burdensome	ADJ
gs-4062	901	11	regimens	regimen	NOUN
gs-4062	901	12	is	be	AUX
gs-4062	901	13	now	now	ADV
gs-4062	901	14	a	a	DET
gs-4062	901	15	historical	historical	ADJ
gs-4062	901	16	footnote	footnote	NOUN
gs-4062	901	17	,	,	PUNCT
gs-4062	901	18	replaced	replace	VERB
gs-4062	901	19	by	by	ADP
gs-4062	901	20	an	an	DET
gs-4062	901	21	age	age	NOUN
gs-4062	901	22	of	of	ADP
gs-4062	901	23	unparalleled	unparalleled	ADJ
gs-4062	901	24	therapeutic	therapeutic	ADJ
gs-4062	901	25	elegance	elegance	NOUN
gs-4062	901	26	,	,	PUNCT
gs-4062	901	27	efficacy	efficacy	NOUN
gs-4062	901	28	,	,	PUNCT
gs-4062	901	29	and	and	CCONJ
gs-4062	901	30	patient	patient	NOUN
gs-4062	901	31	-	-	PUNCT
gs-4062	901	32	centricity	centricity	NOUN
gs-4062	901	33	.	.	PUNCT
gs-4062	902	1	the	the	DET
gs-4062	902	2	conclusions	conclusion	NOUN
gs-4062	902	3	drawn	draw	VERB
gs-4062	902	4	are	be	AUX
gs-4062	902	5	not	not	PART
gs-4062	902	6	merely	merely	ADV
gs-4062	902	7	summative	summative	ADJ
gs-4062	902	8	but	but	CCONJ
gs-4062	902	9	prescriptive	prescriptive	ADJ
gs-4062	902	10	,	,	PUNCT
gs-4062	902	11	outlining	outline	VERB
gs-4062	902	12	the	the	DET
gs-4062	902	13	trajectory	trajectory	NOUN
gs-4062	902	14	for	for	ADP
gs-4062	902	15	future	future	ADJ
gs-4062	902	16	research	research	NOUN
gs-4062	902	17	,	,	PUNCT
gs-4062	902	18	clinical	clinical	ADJ
gs-4062	902	19	practice	practice	NOUN
gs-4062	902	20	,	,	PUNCT
gs-4062	902	21	and	and	CCONJ
gs-4062	902	22	public	public	ADJ
gs-4062	902	23	health	health	NOUN
gs-4062	902	24	policy	policy	NOUN
gs-4062	902	25	.	.	PUNCT
gs-4062	903	1	first	first	ADV
gs-4062	903	2	,	,	PUNCT
gs-4062	903	3	it	it	PRON
gs-4062	903	4	is	be	AUX
gs-4062	903	5	conclusively	conclusively	ADV
gs-4062	903	6	established	establish	VERB
gs-4062	903	7	that	that	SCONJ
gs-4062	903	8	the	the	DET
gs-4062	903	9	pharmacological	pharmacological	ADJ
gs-4062	903	10	and	and	CCONJ
gs-4062	903	11	clinical	clinical	ADJ
gs-4062	903	12	superiority	superiority	NOUN
gs-4062	903	13	of	of	ADP
gs-4062	903	14	secondgeneration	secondgeneration	NOUN
gs-4062	903	15	integrase	integrase	NOUN
gs-4062	903	16	strand	strand	NOUN
gs-4062	903	17	transfer	transfer	NOUN
gs-4062	903	18	inhibitors	inhibitor	NOUN
gs-4062	903	19	,	,	PUNCT
gs-4062	903	20	namely	namely	ADV
gs-4062	903	21	dolutegravir	dolutegravir	PROPN
gs-4062	903	22	and	and	CCONJ
gs-4062	903	23	bictegravir	bictegravir	PROPN
gs-4062	903	24	,	,	PUNCT
gs-4062	903	25	has	have	AUX
gs-4062	903	26	solidified	solidify	VERB
gs-4062	903	27	a	a	DET
gs-4062	903	28	georgian	georgian	NOUN
gs-4062	903	29	scientists/	scientists/	NUM
gs-4062	903	30	.	.	PUNCT
gs-4062	904	1	7	7	NUM
gs-4062	904	2	n	n	PRON
gs-4062	904	3	3	3	NUM
gs-4062	904	4	,	,	PUNCT
gs-4062	904	5	2025	2025	NUM
gs-4062	904	6	560	560	NUM
gs-4062	904	7	new	new	ADJ
gs-4062	904	8	,	,	PUNCT
gs-4062	904	9	robust	robust	ADJ
gs-4062	904	10	global	global	ADJ
gs-4062	904	11	standard	standard	NOUN
gs-4062	904	12	for	for	ADP
gs-4062	904	13	first	first	ADJ
gs-4062	904	14	-	-	PUNCT
gs-4062	904	15	line	line	NOUN
gs-4062	904	16	therapy	therapy	NOUN
gs-4062	904	17	.	.	PUNCT
gs-4062	905	1	their	their	PRON
gs-4062	905	2	high	high	ADJ
gs-4062	905	3	genetic	genetic	ADJ
gs-4062	905	4	barrier	barrier	NOUN
gs-4062	905	5	to	to	ADP
gs-4062	905	6	resistance	resistance	NOUN
gs-4062	905	7	provides	provide	VERB
gs-4062	905	8	a	a	DET
gs-4062	905	9	forgiving	forgiving	ADJ
gs-4062	905	10	and	and	CCONJ
gs-4062	905	11	durable	durable	ADJ
gs-4062	905	12	platform	platform	NOUN
gs-4062	905	13	for	for	ADP
gs-4062	905	14	lifelong	lifelong	ADJ
gs-4062	905	15	care	care	NOUN
gs-4062	905	16	,	,	PUNCT
gs-4062	905	17	effectively	effectively	ADV
gs-4062	905	18	minimizing	minimize	VERB
gs-4062	905	19	the	the	DET
gs-4062	905	20	threat	threat	NOUN
gs-4062	905	21	of	of	ADP
gs-4062	905	22	virological	virological	ADJ
gs-4062	905	23	failure	failure	NOUN
gs-4062	905	24	and	and	CCONJ
gs-4062	905	25	the	the	DET
gs-4062	905	26	emergence	emergence	NOUN
gs-4062	905	27	of	of	ADP
gs-4062	905	28	complex	complex	ADJ
gs-4062	905	29	resistance	resistance	NOUN
gs-4062	905	30	patterns	pattern	NOUN
gs-4062	905	31	.	.	PUNCT
gs-4062	906	1	the	the	DET
gs-4062	906	2	concerning	concern	VERB
gs-4062	906	3	initial	initial	ADJ
gs-4062	906	4	signals	signal	NOUN
gs-4062	906	5	of	of	ADP
gs-4062	906	6	weight	weight	NOUN
gs-4062	906	7	gain	gain	NOUN
gs-4062	906	8	have	have	AUX
gs-4062	906	9	been	be	AUX
gs-4062	906	10	thoroughly	thoroughly	ADV
gs-4062	906	11	contextualized	contextualize	VERB
gs-4062	906	12	by	by	ADP
gs-4062	906	13	long	long	ADJ
gs-4062	906	14	-	-	PUNCT
gs-4062	906	15	term	term	NOUN
gs-4062	906	16	data	datum	NOUN
gs-4062	906	17	.	.	PUNCT
gs-4062	907	1	it	it	PRON
gs-4062	907	2	is	be	AUX
gs-4062	907	3	concluded	conclude	VERB
gs-4062	907	4	that	that	SCONJ
gs-4062	907	5	while	while	SCONJ
gs-4062	907	6	this	this	PRON
gs-4062	907	7	is	be	AUX
gs-4062	907	8	a	a	DET
gs-4062	907	9	real	real	ADJ
gs-4062	907	10	and	and	CCONJ
gs-4062	907	11	clinically	clinically	ADV
gs-4062	907	12	significant	significant	ADJ
gs-4062	907	13	class	class	NOUN
gs-4062	907	14	effect	effect	NOUN
gs-4062	907	15	,	,	PUNCT
gs-4062	907	16	its	its	PRON
gs-4062	907	17	character	character	NOUN
gs-4062	907	18	—	—	PUNCT
gs-4062	907	19	often	often	ADV
gs-4062	907	20	involving	involve	VERB
gs-4062	907	21	lean	lean	ADJ
gs-4062	907	22	mass	mass	NOUN
gs-4062	907	23	—	—	PUNCT
gs-4062	907	24	and	and	CCONJ
gs-4062	907	25	its	its	PRON
gs-4062	907	26	tendency	tendency	NOUN
gs-4062	907	27	to	to	PART
gs-4062	907	28	plateau	plateau	VERB
gs-4062	907	29	necessitate	necessitate	ADJ
gs-4062	907	30	a	a	DET
gs-4062	907	31	nuanced	nuanced	ADJ
gs-4062	907	32	,	,	PUNCT
gs-4062	907	33	individualized	individualized	ADJ
gs-4062	907	34	approach	approach	NOUN
gs-4062	907	35	to	to	ADP
gs-4062	907	36	management	management	NOUN
gs-4062	907	37	rather	rather	ADV
gs-4062	907	38	than	than	ADP
gs-4062	907	39	a	a	DET
gs-4062	907	40	wholesale	wholesale	ADJ
gs-4062	907	41	rejection	rejection	NOUN
gs-4062	907	42	of	of	ADP
gs-4062	907	43	these	these	DET
gs-4062	907	44	profoundly	profoundly	ADV
gs-4062	907	45	effective	effective	ADJ
gs-4062	907	46	drugs	drug	NOUN
gs-4062	907	47	.	.	PUNCT
gs-4062	908	1	the	the	DET
gs-4062	908	2	risk	risk	NOUN
gs-4062	908	3	-	-	PUNCT
gs-4062	908	4	benefit	benefit	NOUN
gs-4062	908	5	calculus	calculus	NOUN
gs-4062	908	6	overwhelmingly	overwhelmingly	ADV
gs-4062	908	7	favors	favor	VERB
gs-4062	908	8	their	their	PRON
gs-4062	908	9	use	use	NOUN
gs-4062	908	10	,	,	PUNCT
gs-4062	908	11	a	a	DET
gs-4062	908	12	conclusion	conclusion	NOUN
gs-4062	908	13	enshrined	enshrine	VERB
gs-4062	908	14	in	in	ADP
gs-4062	908	15	treatment	treatment	NOUN
gs-4062	908	16	guidelines	guideline	NOUN
gs-4062	908	17	worldwide	worldwide	ADV
gs-4062	908	18	.	.	PUNCT
gs-4062	909	1	second	second	ADV
gs-4062	909	2	,	,	PUNCT
gs-4062	909	3	the	the	DET
gs-4062	909	4	successful	successful	ADJ
gs-4062	909	5	development	development	NOUN
gs-4062	909	6	and	and	CCONJ
gs-4062	909	7	deployment	deployment	NOUN
gs-4062	909	8	of	of	ADP
gs-4062	909	9	long	long	ADV
gs-4062	909	10	-	-	PUNCT
gs-4062	909	11	acting	act	VERB
gs-4062	909	12	injectable	injectable	ADJ
gs-4062	909	13	formulations	formulation	NOUN
gs-4062	909	14	of	of	ADP
gs-4062	909	15	cabotegravir	cabotegravir	PRON
gs-4062	909	16	and	and	CCONJ
gs-4062	909	17	rilpivirine	rilpivirine	VERB
gs-4062	909	18	represent	represent	VERB
gs-4062	909	19	a	a	DET
gs-4062	909	20	paradigm	paradigm	NOUN
gs-4062	909	21	shift	shift	NOUN
gs-4062	909	22	of	of	ADP
gs-4062	909	23	monumental	monumental	ADJ
gs-4062	909	24	importance	importance	NOUN
gs-4062	909	25	.	.	PUNCT
gs-4062	910	1	it	it	PRON
gs-4062	910	2	is	be	AUX
gs-4062	910	3	concluded	conclude	VERB
gs-4062	910	4	that	that	SCONJ
gs-4062	910	5	this	this	DET
gs-4062	910	6	modality	modality	NOUN
gs-4062	910	7	is	be	AUX
gs-4062	910	8	not	not	PART
gs-4062	910	9	a	a	DET
gs-4062	910	10	mere	mere	ADJ
gs-4062	910	11	alternative	alternative	NOUN
gs-4062	910	12	but	but	CCONJ
gs-4062	910	13	a	a	DET
gs-4062	910	14	fundamental	fundamental	ADJ
gs-4062	910	15	expansion	expansion	NOUN
gs-4062	910	16	of	of	ADP
gs-4062	910	17	the	the	DET
gs-4062	910	18	therapeutic	therapeutic	ADJ
gs-4062	910	19	arsenal	arsenal	NOUN
gs-4062	910	20	that	that	PRON
gs-4062	910	21	directly	directly	ADV
gs-4062	910	22	addresses	address	VERB
gs-4062	910	23	the	the	DET
gs-4062	910	24	psychosocial	psychosocial	ADJ
gs-4062	910	25	dimensions	dimension	NOUN
gs-4062	910	26	of	of	ADP
gs-4062	910	27	hiv	hiv	PROPN
gs-4062	910	28	.	.	PUNCT
gs-4062	911	1	by	by	ADP
gs-4062	911	2	decoupling	decouple	VERB
gs-4062	911	3	disease	disease	NOUN
gs-4062	911	4	management	management	NOUN
gs-4062	911	5	from	from	ADP
gs-4062	911	6	a	a	DET
gs-4062	911	7	daily	daily	ADJ
gs-4062	911	8	pill	pill	NOUN
gs-4062	911	9	,	,	PUNCT
gs-4062	911	10	this	this	DET
gs-4062	911	11	approach	approach	NOUN
gs-4062	911	12	demonstrably	demonstrably	ADV
gs-4062	911	13	reduces	reduce	VERB
gs-4062	911	14	internalized	internalized	ADJ
gs-4062	911	15	stigma	stigma	NOUN
gs-4062	911	16	,	,	PUNCT
gs-4062	911	17	improves	improve	VERB
gs-4062	911	18	quality	quality	NOUN
gs-4062	911	19	of	of	ADP
gs-4062	911	20	life	life	NOUN
gs-4062	911	21	,	,	PUNCT
gs-4062	911	22	and	and	CCONJ
gs-4062	911	23	enhances	enhance	VERB
gs-4062	911	24	mental	mental	ADJ
gs-4062	911	25	well	well	ADV
gs-4062	911	26	-	-	PUNCT
gs-4062	911	27	being	being	NOUN
gs-4062	911	28	,	,	PUNCT
gs-4062	911	29	thereby	thereby	ADV
gs-4062	911	30	redefining	redefine	VERB
gs-4062	911	31	the	the	DET
gs-4062	911	32	very	very	ADJ
gs-4062	911	33	meaning	meaning	NOUN
gs-4062	911	34	of	of	ADP
gs-4062	911	35	successful	successful	ADJ
gs-4062	911	36	treatment	treatment	NOUN
gs-4062	911	37	.	.	PUNCT
gs-4062	912	1	the	the	DET
gs-4062	912	2	challenges	challenge	NOUN
gs-4062	912	3	of	of	ADP
gs-4062	912	4	injection	injection	NOUN
gs-4062	912	5	site	site	NOUN
gs-4062	912	6	reactions	reaction	NOUN
gs-4062	912	7	and	and	CCONJ
gs-4062	912	8	logistical	logistical	ADJ
gs-4062	912	9	infrastructure	infrastructure	NOUN
gs-4062	912	10	are	be	AUX
gs-4062	912	11	concluded	conclude	VERB
gs-4062	912	12	to	to	PART
gs-4062	912	13	be	be	AUX
gs-4062	912	14	manageable	manageable	ADJ
gs-4062	912	15	hurdles	hurdle	NOUN
gs-4062	912	16	,	,	PUNCT
gs-4062	912	17	far	far	ADV
gs-4062	912	18	outweighed	outweigh	VERB
gs-4062	912	19	by	by	ADP
gs-4062	912	20	the	the	DET
gs-4062	912	21	profound	profound	ADJ
gs-4062	912	22	benefits	benefit	NOUN
gs-4062	912	23	of	of	ADP
gs-4062	912	24	unprecedented	unprecedented	ADJ
gs-4062	912	25	adherence	adherence	NOUN
gs-4062	912	26	and	and	CCONJ
gs-4062	912	27	patient	patient	ADJ
gs-4062	912	28	preference	preference	NOUN
gs-4062	912	29	.	.	PUNCT
gs-4062	913	1	third	third	ADV
gs-4062	913	2	,	,	PUNCT
gs-4062	913	3	the	the	DET
gs-4062	913	4	advent	advent	NOUN
gs-4062	913	5	of	of	ADP
gs-4062	913	6	agents	agent	NOUN
gs-4062	913	7	with	with	ADP
gs-4062	913	8	entirely	entirely	ADV
gs-4062	913	9	novel	novel	ADJ
gs-4062	913	10	mechanisms	mechanism	NOUN
gs-4062	913	11	of	of	ADP
gs-4062	913	12	action	action	NOUN
gs-4062	913	13	,	,	PUNCT
gs-4062	913	14	most	most	ADV
gs-4062	913	15	notably	notably	ADV
gs-4062	913	16	the	the	DET
gs-4062	913	17	capsid	capsid	ADJ
gs-4062	913	18	inhibitor	inhibitor	NOUN
gs-4062	913	19	lenacapavir	lenacapavir	PROPN
gs-4062	913	20	,	,	PUNCT
gs-4062	913	21	has	have	AUX
gs-4062	913	22	conclusively	conclusively	ADV
gs-4062	913	23	proven	prove	VERB
gs-4062	913	24	that	that	SCONJ
gs-4062	913	25	hiv	hiv	PROPN
gs-4062	913	26	's	's	PART
gs-4062	913	27	therapeutic	therapeutic	ADJ
gs-4062	913	28	vulnerabilities	vulnerability	NOUN
gs-4062	913	29	are	be	AUX
gs-4062	913	30	not	not	PART
gs-4062	913	31	yet	yet	ADV
gs-4062	913	32	exhausted	exhausted	ADJ
gs-4062	913	33	.	.	PUNCT
gs-4062	914	1	this	this	DET
gs-4062	914	2	breakthrough	breakthrough	NOUN
gs-4062	914	3	provides	provide	VERB
gs-4062	914	4	a	a	DET
gs-4062	914	5	powerful	powerful	ADJ
gs-4062	914	6	salvage	salvage	NOUN
gs-4062	914	7	option	option	NOUN
gs-4062	914	8	for	for	ADP
gs-4062	914	9	the	the	DET
gs-4062	914	10	most	most	ADV
gs-4062	914	11	treatmentexperienced	treatmentexperienced	ADJ
gs-4062	914	12	patients	patient	NOUN
gs-4062	914	13	and	and	CCONJ
gs-4062	914	14	paves	pave	VERB
gs-4062	914	15	the	the	DET
gs-4062	914	16	way	way	NOUN
gs-4062	914	17	for	for	ADP
gs-4062	914	18	future	future	ADJ
gs-4062	914	19	regimens	regimen	NOUN
gs-4062	914	20	built	build	VERB
gs-4062	914	21	on	on	ADP
gs-4062	914	22	long	long	ADV
gs-4062	914	23	-	-	PUNCT
gs-4062	914	24	acting	act	VERB
gs-4062	914	25	,	,	PUNCT
gs-4062	914	26	resistance	resistance	NOUN
gs-4062	914	27	-	-	PUNCT
gs-4062	914	28	proof	proof	ADJ
gs-4062	914	29	pillars	pillar	NOUN
gs-4062	914	30	.	.	PUNCT
gs-4062	915	1	the	the	DET
gs-4062	915	2	efficacy	efficacy	NOUN
gs-4062	915	3	of	of	ADP
gs-4062	915	4	lenacapavir	lenacapavir	PROPN
gs-4062	915	5	,	,	PUNCT
gs-4062	915	6	even	even	ADV
gs-4062	915	7	against	against	ADP
gs-4062	915	8	multi	multi	ADJ
gs-4062	915	9	-	-	ADJ
gs-4062	915	10	class	class	ADJ
gs-4062	915	11	resistant	resistant	ADJ
gs-4062	915	12	virus	virus	NOUN
gs-4062	915	13	,	,	PUNCT
gs-4062	915	14	underscores	underscore	VERB
gs-4062	915	15	the	the	DET
gs-4062	915	16	critical	critical	ADJ
gs-4062	915	17	importance	importance	NOUN
gs-4062	915	18	of	of	ADP
gs-4062	915	19	continued	continue	VERB
gs-4062	915	20	investment	investment	NOUN
gs-4062	915	21	in	in	ADP
gs-4062	915	22	basic	basic	ADJ
gs-4062	915	23	virology	virology	NOUN
gs-4062	915	24	and	and	CCONJ
gs-4062	915	25	drug	drug	NOUN
gs-4062	915	26	discovery	discovery	NOUN
gs-4062	915	27	.	.	PUNCT
gs-4062	916	1	it	it	PRON
gs-4062	916	2	is	be	AUX
gs-4062	916	3	concluded	conclude	VERB
gs-4062	916	4	that	that	SCONJ
gs-4062	916	5	the	the	DET
gs-4062	916	6	future	future	NOUN
gs-4062	916	7	of	of	ADP
gs-4062	916	8	art	art	NOUN
gs-4062	916	9	will	will	AUX
gs-4062	916	10	increasingly	increasingly	ADV
gs-4062	916	11	move	move	VERB
gs-4062	916	12	away	away	ADV
gs-4062	916	13	from	from	ADP
gs-4062	916	14	traditional	traditional	ADJ
gs-4062	916	15	three	three	NUM
gs-4062	916	16	-	-	PUNCT
gs-4062	916	17	drug	drug	NOUN
gs-4062	916	18	combinations	combination	NOUN
gs-4062	916	19	towards	towards	ADP
gs-4062	916	20	potent	potent	NOUN
gs-4062	916	21	,	,	PUNCT
gs-4062	916	22	streamlined	streamline	VERB
gs-4062	916	23	two	two	NUM
gs-4062	916	24	-	-	PUNCT
gs-4062	916	25	drug	drug	NOUN
gs-4062	916	26	,	,	PUNCT
gs-4062	916	27	long	long	ADV
gs-4062	916	28	-	-	PUNCT
gs-4062	916	29	acting	act	VERB
gs-4062	916	30	cocktails	cocktail	NOUN
gs-4062	916	31	that	that	PRON
gs-4062	916	32	could	could	AUX
gs-4062	916	33	be	be	AUX
gs-4062	916	34	administered	administer	VERB
gs-4062	916	35	semi	semi	ADV
gs-4062	916	36	-	-	ADV
gs-4062	916	37	annually	annually	ADV
gs-4062	916	38	or	or	CCONJ
gs-4062	916	39	annually	annually	ADV
gs-4062	916	40	.	.	PUNCT
gs-4062	917	1	fourth	fourth	ADJ
gs-4062	917	2	,	,	PUNCT
gs-4062	917	3	the	the	DET
gs-4062	917	4	exploration	exploration	NOUN
gs-4062	917	5	of	of	ADP
gs-4062	917	6	broadly	broadly	ADV
gs-4062	917	7	neutralizing	neutralize	VERB
gs-4062	917	8	antibodies	antibody	NOUN
gs-4062	917	9	and	and	CCONJ
gs-4062	917	10	gene	gene	NOUN
gs-4062	917	11	-	-	PUNCT
gs-4062	917	12	editing	edit	VERB
gs-4062	917	13	technologies	technology	NOUN
gs-4062	917	14	,	,	PUNCT
gs-4062	917	15	while	while	SCONJ
gs-4062	917	16	still	still	ADV
gs-4062	917	17	in	in	ADP
gs-4062	917	18	earlier	early	ADJ
gs-4062	917	19	stages	stage	NOUN
gs-4062	917	20	,	,	PUNCT
gs-4062	917	21	leads	lead	VERB
gs-4062	917	22	to	to	ADP
gs-4062	917	23	the	the	DET
gs-4062	917	24	conclusive	conclusive	ADJ
gs-4062	917	25	and	and	CCONJ
gs-4062	917	26	optimistic	optimistic	ADJ
gs-4062	917	27	view	view	NOUN
gs-4062	917	28	that	that	SCONJ
gs-4062	917	29	the	the	DET
gs-4062	917	30	pursuit	pursuit	NOUN
gs-4062	917	31	of	of	ADP
gs-4062	917	32	an	an	DET
gs-4062	917	33	hiv	hiv	PROPN
gs-4062	917	34	cure	cure	NOUN
gs-4062	917	35	is	be	AUX
gs-4062	917	36	a	a	DET
gs-4062	917	37	tangible	tangible	ADJ
gs-4062	917	38	,	,	PUNCT
gs-4062	917	39	if	if	SCONJ
gs-4062	917	40	exceedingly	exceedingly	ADV
gs-4062	917	41	complex	complex	ADJ
gs-4062	917	42	,	,	PUNCT
gs-4062	917	43	scientific	scientific	ADJ
gs-4062	917	44	endeavor	endeavor	NOUN
gs-4062	917	45	.	.	PUNCT
gs-4062	918	1	the	the	DET
gs-4062	918	2	results	result	NOUN
gs-4062	918	3	from	from	ADP
gs-4062	918	4	"	"	PUNCT
gs-4062	918	5	kick	kick	VERB
gs-4062	918	6	-	-	PUNCT
gs-4062	918	7	and	and	CCONJ
gs-4062	918	8	-	-	PUNCT
gs-4062	918	9	kill	kill	VERB
gs-4062	918	10	"	"	PUNCT
gs-4062	918	11	strategies	strategy	NOUN
gs-4062	918	12	and	and	CCONJ
gs-4062	918	13	therapeutic	therapeutic	ADJ
gs-4062	918	14	vaccines	vaccine	NOUN
gs-4062	918	15	,	,	PUNCT
gs-4062	918	16	though	though	SCONJ
gs-4062	918	17	modest	modest	ADJ
gs-4062	918	18	,	,	PUNCT
gs-4062	918	19	provide	provide	VERB
gs-4062	918	20	proof	proof	NOUN
gs-4062	918	21	-	-	PUNCT
gs-4062	918	22	of	of	ADP
gs-4062	918	23	-	-	PUNCT
gs-4062	918	24	concept	concept	NOUN
gs-4062	918	25	that	that	SCONJ
gs-4062	918	26	immune	immune	NOUN
gs-4062	918	27	-	-	PUNCT
gs-4062	918	28	mediated	mediate	VERB
gs-4062	918	29	control	control	NOUN
gs-4062	918	30	or	or	CCONJ
gs-4062	918	31	even	even	ADV
gs-4062	918	32	eradication	eradication	NOUN
gs-4062	918	33	of	of	ADP
gs-4062	918	34	the	the	DET
gs-4062	918	35	reservoir	reservoir	NOUN
gs-4062	918	36	is	be	AUX
gs-4062	918	37	possible	possible	ADJ
gs-4062	918	38	.	.	PUNCT
gs-4062	919	1	it	it	PRON
gs-4062	919	2	is	be	AUX
gs-4062	919	3	concluded	conclude	VERB
gs-4062	919	4	that	that	SCONJ
gs-4062	919	5	the	the	DET
gs-4062	919	6	path	path	NOUN
gs-4062	919	7	to	to	ADP
gs-4062	919	8	a	a	DET
gs-4062	919	9	cure	cure	NOUN
gs-4062	919	10	will	will	AUX
gs-4062	919	11	not	not	PART
gs-4062	919	12	be	be	AUX
gs-4062	919	13	a	a	DET
gs-4062	919	14	single	single	ADJ
gs-4062	919	15	breakthrough	breakthrough	NOUN
gs-4062	919	16	but	but	CCONJ
gs-4062	919	17	a	a	DET
gs-4062	919	18	gradual	gradual	ADJ
gs-4062	919	19	process	process	NOUN
gs-4062	919	20	of	of	ADP
gs-4062	919	21	scientific	scientific	ADJ
gs-4062	919	22	iteration	iteration	NOUN
gs-4062	919	23	,	,	PUNCT
gs-4062	919	24	likely	likely	ADV
gs-4062	919	25	involving	involve	VERB
gs-4062	919	26	combinations	combination	NOUN
gs-4062	919	27	of	of	ADP
gs-4062	919	28	these	these	DET
gs-4062	919	29	novel	novel	ADJ
gs-4062	919	30	immunotherapies	immunotherapy	NOUN
gs-4062	919	31	and	and	CCONJ
gs-4062	919	32	gene	gene	NOUN
gs-4062	919	33	therapies	therapy	NOUN
gs-4062	919	34	.	.	PUNCT
gs-4062	920	1	however	however	ADV
gs-4062	920	2	,	,	PUNCT
gs-4062	920	3	these	these	DET
gs-4062	920	4	triumphant	triumphant	ADJ
gs-4062	920	5	scientific	scientific	ADJ
gs-4062	920	6	conclusions	conclusion	NOUN
gs-4062	920	7	are	be	AUX
gs-4062	920	8	starkly	starkly	ADV
gs-4062	920	9	contrasted	contrast	VERB
gs-4062	920	10	by	by	ADP
gs-4062	920	11	a	a	DET
gs-4062	920	12	sobering	sobering	ADJ
gs-4062	920	13	socioeconomic	socioeconomic	ADJ
gs-4062	920	14	reality	reality	NOUN
gs-4062	920	15	.	.	PUNCT
gs-4062	921	1	the	the	DET
gs-4062	921	2	most	most	ADV
gs-4062	921	3	urgent	urgent	ADJ
gs-4062	921	4	and	and	CCONJ
gs-4062	921	5	damning	damning	ADJ
gs-4062	921	6	conclusion	conclusion	NOUN
gs-4062	921	7	of	of	ADP
gs-4062	921	8	this	this	DET
gs-4062	921	9	analysis	analysis	NOUN
gs-4062	921	10	is	be	AUX
gs-4062	921	11	the	the	DET
gs-4062	921	12	vast	vast	ADJ
gs-4062	921	13	and	and	CCONJ
gs-4062	921	14	growing	grow	VERB
gs-4062	921	15	chasm	chasm	NOUN
gs-4062	921	16	between	between	ADP
gs-4062	921	17	therapeutic	therapeutic	ADJ
gs-4062	921	18	possibility	possibility	NOUN
gs-4062	921	19	and	and	CCONJ
gs-4062	921	20	equitable	equitable	ADJ
gs-4062	921	21	access	access	NOUN
gs-4062	921	22	.	.	PUNCT
gs-4062	922	1	the	the	DET
gs-4062	922	2	brilliant	brilliant	ADJ
gs-4062	922	3	advancements	advancement	NOUN
gs-4062	922	4	in	in	ADP
gs-4062	922	5	longacting	longacte	VERB
gs-4062	922	6	therapies	therapy	NOUN
gs-4062	922	7	and	and	CCONJ
gs-4062	922	8	novel	novel	ADJ
gs-4062	922	9	agents	agent	NOUN
gs-4062	922	10	remain	remain	VERB
gs-4062	922	11	almost	almost	ADV
gs-4062	922	12	exclusively	exclusively	ADV
gs-4062	922	13	the	the	DET
gs-4062	922	14	privilege	privilege	NOUN
gs-4062	922	15	of	of	ADP
gs-4062	922	16	high	high	ADJ
gs-4062	922	17	-	-	PUNCT
gs-4062	922	18	income	income	NOUN
gs-4062	922	19	countries	country	NOUN
gs-4062	922	20	,	,	PUNCT
gs-4062	922	21	while	while	SCONJ
gs-4062	922	22	public	public	ADJ
gs-4062	922	23	health	health	NOUN
gs-4062	922	24	systems	system	NOUN
gs-4062	922	25	in	in	ADP
gs-4062	922	26	the	the	DET
gs-4062	922	27	regions	region	NOUN
gs-4062	922	28	most	most	ADJ
gs-4062	922	29	burden	burden	NOUN
gs-4062	922	30	by	by	ADP
gs-4062	922	31	the	the	DET
gs-4062	922	32	epidemic	epidemic	NOUN
gs-4062	922	33	lack	lack	NOUN
gs-4062	922	34	access	access	NOUN
gs-4062	922	35	even	even	ADV
gs-4062	922	36	to	to	ADP
gs-4062	922	37	previous	previous	ADJ
gs-4062	922	38	generations	generation	NOUN
gs-4062	922	39	of	of	ADP
gs-4062	922	40	care	care	NOUN
gs-4062	922	41	.	.	PUNCT
gs-4062	923	1	it	it	PRON
gs-4062	923	2	is	be	AUX
gs-4062	923	3	conclusively	conclusively	ADV
gs-4062	923	4	determined	determined	ADJ
gs-4062	923	5	that	that	SCONJ
gs-4062	923	6	without	without	ADP
gs-4062	923	7	aggressive	aggressive	ADJ
gs-4062	923	8	,	,	PUNCT
gs-4062	923	9	globalized	globalized	ADJ
gs-4062	923	10	intervention	intervention	NOUN
gs-4062	923	11	—	—	PUNCT
gs-4062	923	12	through	through	ADP
gs-4062	923	13	patent	patent	NOUN
gs-4062	923	14	pooling	pooling	NOUN
gs-4062	923	15	,	,	PUNCT
gs-4062	923	16	technology	technology	NOUN
gs-4062	923	17	transfer	transfer	NOUN
gs-4062	923	18	,	,	PUNCT
gs-4062	923	19	generic	generic	ADJ
gs-4062	923	20	licensing	licensing	NOUN
gs-4062	923	21	,	,	PUNCT
gs-4062	923	22	and	and	CCONJ
gs-4062	923	23	massive	massive	ADJ
gs-4062	923	24	international	international	ADJ
gs-4062	923	25	funding	funding	NOUN
gs-4062	923	26	—	—	PUNCT
gs-4062	923	27	these	these	DET
gs-4062	923	28	scientific	scientific	ADJ
gs-4062	923	29	achievements	achievement	NOUN
gs-4062	923	30	will	will	AUX
gs-4062	923	31	paradoxically	paradoxically	ADV
gs-4062	923	32	fuel	fuel	VERB
gs-4062	923	33	deeper	deep	ADJ
gs-4062	923	34	health	health	NOUN
gs-4062	923	35	inequities	inequity	NOUN
gs-4062	923	36	.	.	PUNCT
gs-4062	924	1	this	this	PRON
gs-4062	924	2	is	be	AUX
gs-4062	924	3	not	not	PART
gs-4062	924	4	only	only	ADV
gs-4062	924	5	an	an	DET
gs-4062	924	6	ethical	ethical	ADJ
gs-4062	924	7	failure	failure	NOUN
gs-4062	924	8	but	but	CCONJ
gs-4062	924	9	a	a	DET
gs-4062	924	10	practical	practical	ADJ
gs-4062	924	11	threat	threat	NOUN
gs-4062	924	12	to	to	ADP
gs-4062	924	13	global	global	ADJ
gs-4062	924	14	health	health	NOUN
gs-4062	924	15	security	security	NOUN
gs-4062	924	16	,	,	PUNCT
gs-4062	924	17	as	as	ADP
gs-4062	924	18	unchecked	unchecked	ADJ
gs-4062	924	19	transmission	transmission	NOUN
gs-4062	924	20	elsewhere	elsewhere	ADV
gs-4062	924	21	risks	risk	NOUN
gs-4062	924	22	spawning	spawn	VERB
gs-4062	924	23	resistant	resistant	ADJ
gs-4062	924	24	viruses	virus	NOUN
gs-4062	924	25	that	that	PRON
gs-4062	924	26	know	know	VERB
gs-4062	924	27	no	no	DET
gs-4062	924	28	borders	border	NOUN
gs-4062	924	29	.	.	PUNCT
gs-4062	925	1	georgian	georgian	NOUN
gs-4062	925	2	scientists/	scientists/	NUM
gs-4062	925	3	.	.	PUNCT
gs-4062	926	1	7	7	NUM
gs-4062	926	2	n	n	PRON
gs-4062	926	3	3	3	NUM
gs-4062	926	4	,	,	PUNCT
gs-4062	926	5	2025	2025	NUM
gs-4062	926	6	561	561	NUM
gs-4062	926	7	finally	finally	ADV
gs-4062	926	8	,	,	PUNCT
gs-4062	926	9	it	it	PRON
gs-4062	926	10	is	be	AUX
gs-4062	926	11	concluded	conclude	VERB
gs-4062	926	12	that	that	SCONJ
gs-4062	926	13	the	the	DET
gs-4062	926	14	future	future	NOUN
gs-4062	926	15	of	of	ADP
gs-4062	926	16	hiv	hiv	PROPN
gs-4062	926	17	medicine	medicine	NOUN
gs-4062	926	18	lies	lie	VERB
gs-4062	926	19	in	in	ADP
gs-4062	926	20	hyper	hyper	NOUN
gs-4062	926	21	-	-	NOUN
gs-4062	926	22	personalization	personalization	NOUN
gs-4062	926	23	,	,	PUNCT
gs-4062	926	24	guided	guide	VERB
gs-4062	926	25	by	by	ADP
gs-4062	926	26	artificial	artificial	ADJ
gs-4062	926	27	intelligence	intelligence	NOUN
gs-4062	926	28	and	and	CCONJ
gs-4062	926	29	advanced	advanced	ADJ
gs-4062	926	30	diagnostics	diagnostic	NOUN
gs-4062	926	31	.	.	PUNCT
gs-4062	927	1	the	the	DET
gs-4062	927	2	choice	choice	NOUN
gs-4062	927	3	of	of	ADP
gs-4062	927	4	regimen	regimen	NOUN
gs-4062	927	5	will	will	AUX
gs-4062	927	6	no	no	ADV
gs-4062	927	7	longer	long	ADV
gs-4062	927	8	be	be	AUX
gs-4062	927	9	guided	guide	VERB
gs-4062	927	10	by	by	ADP
gs-4062	927	11	a	a	DET
gs-4062	927	12	monolithic	monolithic	ADJ
gs-4062	927	13	protocol	protocol	NOUN
gs-4062	927	14	but	but	CCONJ
gs-4062	927	15	will	will	AUX
gs-4062	927	16	be	be	AUX
gs-4062	927	17	tailored	tailor	VERB
gs-4062	927	18	to	to	ADP
gs-4062	927	19	an	an	DET
gs-4062	927	20	individual	individual	NOUN
gs-4062	927	21	's	's	PART
gs-4062	927	22	genetic	genetic	ADJ
gs-4062	927	23	predisposition	predisposition	NOUN
gs-4062	927	24	to	to	ADP
gs-4062	927	25	side	side	NOUN
gs-4062	927	26	effects	effect	NOUN
gs-4062	927	27	,	,	PUNCT
gs-4062	927	28	their	their	PRON
gs-4062	927	29	viral	viral	ADJ
gs-4062	927	30	subtype	subtype	NOUN
gs-4062	927	31	,	,	PUNCT
gs-4062	927	32	their	their	PRON
gs-4062	927	33	lifestyle	lifestyle	NOUN
gs-4062	927	34	preferences	preference	NOUN
gs-4062	927	35	,	,	PUNCT
gs-4062	927	36	and	and	CCONJ
gs-4062	927	37	their	their	PRON
gs-4062	927	38	comorbid	comorbid	NOUN
gs-4062	927	39	conditions	condition	NOUN
gs-4062	927	40	.	.	PUNCT
gs-4062	928	1	the	the	DET
gs-4062	928	2	goal	goal	NOUN
gs-4062	928	3	is	be	AUX
gs-4062	928	4	no	no	ADV
gs-4062	928	5	longer	long	ADV
gs-4062	928	6	just	just	ADV
gs-4062	928	7	an	an	DET
gs-4062	928	8	undetectable	undetectable	ADJ
gs-4062	928	9	viral	viral	ADJ
gs-4062	928	10	load	load	NOUN
gs-4062	928	11	,	,	PUNCT
gs-4062	928	12	but	but	CCONJ
gs-4062	928	13	the	the	DET
gs-4062	928	14	optimization	optimization	NOUN
gs-4062	928	15	of	of	ADP
gs-4062	928	16	overall	overall	ADJ
gs-4062	928	17	health	health	NOUN
gs-4062	928	18	and	and	CCONJ
gs-4062	928	19	longevity	longevity	NOUN
gs-4062	928	20	.	.	PUNCT
gs-4062	929	1	in	in	ADP
gs-4062	929	2	ultimate	ultimate	ADJ
gs-4062	929	3	summation	summation	NOUN
gs-4062	929	4	,	,	PUNCT
gs-4062	929	5	the	the	DET
gs-4062	929	6	scientific	scientific	ADJ
gs-4062	929	7	journey	journey	NOUN
gs-4062	929	8	chronicled	chronicle	VERB
gs-4062	929	9	here	here	ADV
gs-4062	929	10	concludes	conclude	VERB
gs-4062	929	11	that	that	SCONJ
gs-4062	929	12	humanity	humanity	NOUN
gs-4062	929	13	possesses	possesse	NOUN
gs-4062	929	14	,	,	PUNCT
gs-4062	929	15	or	or	CCONJ
gs-4062	929	16	is	be	AUX
gs-4062	929	17	imminently	imminently	ADV
gs-4062	929	18	developing	develop	VERB
gs-4062	929	19	,	,	PUNCT
gs-4062	929	20	the	the	DET
gs-4062	929	21	technical	technical	ADJ
gs-4062	929	22	tools	tool	NOUN
gs-4062	929	23	to	to	PART
gs-4062	929	24	end	end	VERB
gs-4062	929	25	the	the	DET
gs-4062	929	26	aids	aids	PROPN
gs-4062	929	27	epidemic	epidemic	NOUN
gs-4062	929	28	as	as	ADP
gs-4062	929	29	a	a	DET
gs-4062	929	30	public	public	ADJ
gs-4062	929	31	health	health	NOUN
gs-4062	929	32	threat	threat	NOUN
gs-4062	929	33	.	.	PUNCT
gs-4062	930	1	the	the	DET
gs-4062	930	2	molecules	molecule	NOUN
gs-4062	930	3	,	,	PUNCT
gs-4062	930	4	the	the	DET
gs-4062	930	5	formulations	formulation	NOUN
gs-4062	930	6	,	,	PUNCT
gs-4062	930	7	and	and	CCONJ
gs-4062	930	8	the	the	DET
gs-4062	930	9	strategies	strategy	NOUN
gs-4062	930	10	exist	exist	VERB
gs-4062	930	11	or	or	CCONJ
gs-4062	930	12	are	be	AUX
gs-4062	930	13	within	within	ADP
gs-4062	930	14	reach	reach	NOUN
gs-4062	930	15	.	.	PUNCT
gs-4062	931	1	the	the	DET
gs-4062	931	2	final	final	ADJ
gs-4062	931	3	,	,	PUNCT
gs-4062	931	4	and	and	CCONJ
gs-4062	931	5	most	most	ADV
gs-4062	931	6	important	important	ADJ
gs-4062	931	7	,	,	PUNCT
gs-4062	931	8	conclusion	conclusion	NOUN
gs-4062	931	9	is	be	AUX
gs-4062	931	10	that	that	SCONJ
gs-4062	931	11	the	the	DET
gs-4062	931	12	greatest	great	ADJ
gs-4062	931	13	remaining	remain	VERB
gs-4062	931	14	obstacle	obstacle	NOUN
gs-4062	931	15	is	be	AUX
gs-4062	931	16	no	no	ADV
gs-4062	931	17	longer	long	ADV
gs-4062	931	18	scientific	scientific	ADJ
gs-4062	931	19	,	,	PUNCT
gs-4062	931	20	but	but	CCONJ
gs-4062	931	21	political	political	ADJ
gs-4062	931	22	.	.	PUNCT
gs-4062	932	1	the	the	DET
gs-4062	932	2	challenge	challenge	NOUN
gs-4062	932	3	of	of	ADP
gs-4062	932	4	the	the	DET
gs-4062	932	5	coming	coming	ADJ
gs-4062	932	6	decade	decade	NOUN
gs-4062	932	7	is	be	AUX
gs-4062	932	8	therefore	therefore	ADV
gs-4062	932	9	not	not	PART
gs-4062	932	10	to	to	PART
gs-4062	932	11	discover	discover	VERB
gs-4062	932	12	more	more	ADJ
gs-4062	932	13	new	new	ADJ
gs-4062	932	14	drugs	drug	NOUN
gs-4062	932	15	,	,	PUNCT
gs-4062	932	16	but	but	CCONJ
gs-4062	932	17	to	to	PART
gs-4062	932	18	build	build	VERB
gs-4062	932	19	the	the	DET
gs-4062	932	20	political	political	ADJ
gs-4062	932	21	will	will	NOUN
gs-4062	932	22	,	,	PUNCT
gs-4062	932	23	economic	economic	ADJ
gs-4062	932	24	structures	structure	NOUN
gs-4062	932	25	,	,	PUNCT
gs-4062	932	26	and	and	CCONJ
gs-4062	932	27	moral	moral	ADJ
gs-4062	932	28	conviction	conviction	NOUN
gs-4062	932	29	to	to	PART
gs-4062	932	30	deliver	deliver	VERB
gs-4062	932	31	the	the	DET
gs-4062	932	32	miracles	miracle	NOUN
gs-4062	932	33	of	of	ADP
gs-4062	932	34	modern	modern	ADJ
gs-4062	932	35	science	science	NOUN
gs-4062	932	36	to	to	ADP
gs-4062	932	37	every	every	DET
gs-4062	932	38	person	person	NOUN
gs-4062	932	39	living	live	VERB
gs-4062	932	40	with	with	ADP
gs-4062	932	41	,	,	PUNCT
gs-4062	932	42	and	and	CCONJ
gs-4062	932	43	at	at	ADP
gs-4062	932	44	risk	risk	NOUN
gs-4062	932	45	for	for	ADP
gs-4062	932	46	,	,	PUNCT
gs-4062	932	47	hiv	hiv	PROPN
gs-4062	932	48	,	,	PUNCT
gs-4062	932	49	regardless	regardless	ADV
gs-4062	932	50	of	of	ADP
gs-4062	932	51	geography	geography	NOUN
gs-4062	932	52	or	or	CCONJ
gs-4062	932	53	economic	economic	ADJ
gs-4062	932	54	status	status	NOUN
gs-4062	932	55	.	.	PUNCT
gs-4062	933	1	the	the	DET
gs-4062	933	2	scientific	scientific	ADJ
gs-4062	933	3	work	work	NOUN
gs-4062	933	4	is	be	AUX
gs-4062	933	5	largely	largely	ADV
gs-4062	933	6	complete	complete	ADJ
gs-4062	933	7	;	;	PUNCT
gs-4062	933	8	the	the	DET
gs-4062	933	9	work	work	NOUN
gs-4062	933	10	of	of	ADP
gs-4062	933	11	justice	justice	NOUN
gs-4062	933	12	and	and	CCONJ
gs-4062	933	13	equity	equity	NOUN
gs-4062	933	14	has	have	AUX
gs-4062	933	15	only	only	ADV
gs-4062	933	16	just	just	ADV
gs-4062	933	17	begun	begin	VERB
gs-4062	933	18	.	.	PUNCT
gs-4062	934	1	recommendations	recommendation	NOUN
gs-4062	934	2	adopt	adopt	VERB
gs-4062	934	3	a	a	DET
gs-4062	934	4	personalized	personalize	VERB
gs-4062	934	5	,	,	PUNCT
gs-4062	934	6	shared	share	VERB
gs-4062	934	7	decision	decision	NOUN
gs-4062	934	8	-	-	PUNCT
gs-4062	934	9	making	make	VERB
gs-4062	934	10	model	model	NOUN
gs-4062	934	11	for	for	ADP
gs-4062	934	12	regimen	regimen	NOUN
gs-4062	934	13	selection	selection	NOUN
gs-4062	934	14	.	.	PUNCT
gs-4062	935	1	the	the	DET
gs-4062	935	2	one	one	NUM
gs-4062	935	3	-	-	PUNCT
gs-4062	935	4	size	size	NOUN
gs-4062	935	5	-	-	PUNCT
gs-4062	935	6	fits	fit	VERB
gs-4062	935	7	-	-	PUNCT
gs-4062	935	8	all	all	DET
gs-4062	935	9	approach	approach	NOUN
gs-4062	935	10	is	be	AUX
gs-4062	935	11	obsolete	obsolete	ADJ
gs-4062	935	12	.	.	PUNCT
gs-4062	936	1	clinicians	clinician	NOUN
gs-4062	936	2	should	should	AUX
gs-4062	936	3	engage	engage	VERB
gs-4062	936	4	patients	patient	NOUN
gs-4062	936	5	in	in	ADP
gs-4062	936	6	detailed	detailed	ADJ
gs-4062	936	7	discussions	discussion	NOUN
gs-4062	936	8	that	that	PRON
gs-4062	936	9	go	go	VERB
gs-4062	936	10	beyond	beyond	ADP
gs-4062	936	11	viral	viral	ADJ
gs-4062	936	12	suppression	suppression	NOUN
gs-4062	936	13	to	to	PART
gs-4062	936	14	include	include	VERB
gs-4062	936	15	preferences	preference	NOUN
gs-4062	936	16	regarding	regard	VERB
gs-4062	936	17	dosing	dose	VERB
gs-4062	936	18	frequency	frequency	NOUN
gs-4062	936	19	(	(	PUNCT
gs-4062	936	20	daily	daily	ADJ
gs-4062	936	21	oral	oral	NOUN
gs-4062	936	22	vs.	vs.	ADP
gs-4062	936	23	long	long	ADV
gs-4062	936	24	-	-	PUNCT
gs-4062	936	25	acting	act	VERB
gs-4062	936	26	injectable	injectable	NOUN
gs-4062	936	27	)	)	PUNCT
gs-4062	936	28	,	,	PUNCT
gs-4062	936	29	tolerance	tolerance	NOUN
gs-4062	936	30	for	for	ADP
gs-4062	936	31	potential	potential	ADJ
gs-4062	936	32	side	side	NOUN
gs-4062	936	33	effects	effect	NOUN
gs-4062	936	34	(	(	PUNCT
gs-4062	936	35	e.g.	e.g.	ADV
gs-4062	936	36	,	,	PUNCT
gs-4062	936	37	weight	weight	NOUN
gs-4062	936	38	gain	gain	NOUN
gs-4062	936	39	)	)	PUNCT
gs-4062	936	40	,	,	PUNCT
gs-4062	936	41	and	and	CCONJ
gs-4062	936	42	long	long	ADJ
gs-4062	936	43	-	-	PUNCT
gs-4062	936	44	term	term	NOUN
gs-4062	936	45	health	health	NOUN
gs-4062	936	46	goals	goal	NOUN
gs-4062	936	47	.	.	PUNCT
gs-4062	937	1	treatment	treatment	NOUN
gs-4062	937	2	decisions	decision	NOUN
gs-4062	937	3	must	must	AUX
gs-4062	937	4	be	be	AUX
gs-4062	937	5	individualized	individualize	VERB
gs-4062	937	6	based	base	VERB
gs-4062	937	7	on	on	ADP
gs-4062	937	8	a	a	DET
gs-4062	937	9	patient	patient	NOUN
gs-4062	937	10	's	's	PART
gs-4062	937	11	sex	sex	NOUN
gs-4062	937	12	,	,	PUNCT
gs-4062	937	13	age	age	NOUN
gs-4062	937	14	,	,	PUNCT
gs-4062	937	15	genetic	genetic	ADJ
gs-4062	937	16	predispositions	predisposition	NOUN
gs-4062	937	17	,	,	PUNCT
gs-4062	937	18	comorbid	comorbid	NOUN
gs-4062	937	19	conditions	condition	NOUN
gs-4062	937	20	,	,	PUNCT
gs-4062	937	21	and	and	CCONJ
gs-4062	937	22	psychosocial	psychosocial	ADJ
gs-4062	937	23	context	context	NOUN
gs-4062	937	24	.	.	PUNCT
gs-4062	938	1	implement	implement	VERB
gs-4062	938	2	proactive	proactive	ADJ
gs-4062	938	3	monitoring	monitoring	NOUN
gs-4062	938	4	and	and	CCONJ
gs-4062	938	5	management	management	NOUN
gs-4062	938	6	of	of	ADP
gs-4062	938	7	insti	insti	NOUN
gs-4062	938	8	-	-	PUNCT
gs-4062	938	9	associated	associate	VERB
gs-4062	938	10	weight	weight	NOUN
gs-4062	938	11	gain	gain	NOUN
gs-4062	938	12	.	.	PUNCT
gs-4062	939	1	rather	rather	ADV
gs-4062	939	2	than	than	ADP
gs-4062	939	3	reacting	react	VERB
gs-4062	939	4	to	to	ADP
gs-4062	939	5	weight	weight	NOUN
gs-4062	939	6	gain	gain	NOUN
gs-4062	939	7	after	after	SCONJ
gs-4062	939	8	it	it	PRON
gs-4062	939	9	occurs	occur	VERB
gs-4062	939	10	,	,	PUNCT
gs-4062	939	11	clinicians	clinician	NOUN
gs-4062	939	12	should	should	AUX
gs-4062	939	13	adopt	adopt	VERB
gs-4062	939	14	a	a	DET
gs-4062	939	15	proactive	proactive	ADJ
gs-4062	939	16	strategy	strategy	NOUN
gs-4062	939	17	.	.	PUNCT
gs-4062	940	1	this	this	PRON
gs-4062	940	2	includes	include	VERB
gs-4062	940	3	obtaining	obtain	VERB
gs-4062	940	4	baseline	baseline	ADJ
gs-4062	940	5	weight	weight	NOUN
gs-4062	940	6	and	and	CCONJ
gs-4062	940	7	waist	waist	NOUN
gs-4062	940	8	circumference	circumference	NOUN
gs-4062	940	9	,	,	PUNCT
gs-4062	940	10	discussing	discuss	VERB
gs-4062	940	11	the	the	DET
gs-4062	940	12	potential	potential	NOUN
gs-4062	940	13	for	for	ADP
gs-4062	940	14	weight	weight	NOUN
gs-4062	940	15	gain	gain	NOUN
gs-4062	940	16	at	at	ADP
gs-4062	940	17	regimen	regimen	NOUN
gs-4062	940	18	initiation	initiation	NOUN
gs-4062	940	19	,	,	PUNCT
gs-4062	940	20	and	and	CCONJ
gs-4062	940	21	establishing	establish	VERB
gs-4062	940	22	a	a	DET
gs-4062	940	23	monitoring	monitoring	NOUN
gs-4062	940	24	plan	plan	NOUN
gs-4062	940	25	.	.	PUNCT
gs-4062	941	1	for	for	ADP
gs-4062	941	2	patients	patient	NOUN
gs-4062	941	3	experiencing	experience	VERB
gs-4062	941	4	significant	significant	ADJ
gs-4062	941	5	gain	gain	NOUN
gs-4062	941	6	,	,	PUNCT
gs-4062	941	7	a	a	DET
gs-4062	941	8	structured	structured	ADJ
gs-4062	941	9	approach	approach	NOUN
gs-4062	941	10	is	be	AUX
gs-4062	941	11	recommended	recommend	VERB
gs-4062	941	12	:	:	PUNCT
gs-4062	941	13	first	first	ADV
gs-4062	941	14	,	,	PUNCT
gs-4062	941	15	ruling	rule	VERB
gs-4062	941	16	out	out	ADP
gs-4062	941	17	other	other	ADJ
gs-4062	941	18	causes	cause	NOUN
gs-4062	941	19	;	;	PUNCT
gs-4062	941	20	second	second	ADV
gs-4062	941	21	,	,	PUNCT
gs-4062	941	22	emphasizing	emphasize	VERB
gs-4062	941	23	nutritional	nutritional	ADJ
gs-4062	941	24	counseling	counseling	NOUN
gs-4062	941	25	and	and	CCONJ
gs-4062	941	26	physical	physical	ADJ
gs-4062	941	27	activity	activity	NOUN
gs-4062	941	28	;	;	PUNCT
gs-4062	941	29	and	and	CCONJ
gs-4062	941	30	third	third	ADV
gs-4062	941	31	,	,	PUNCT
gs-4062	941	32	considering	consider	VERB
gs-4062	941	33	a	a	DET
gs-4062	941	34	regimen	regimen	NOUN
gs-4062	941	35	switch	switch	NOUN
gs-4062	941	36	to	to	ADP
gs-4062	941	37	an	an	DET
gs-4062	941	38	agent	agent	NOUN
gs-4062	941	39	with	with	ADP
gs-4062	941	40	a	a	DET
gs-4062	941	41	lower	low	ADJ
gs-4062	941	42	weight	weight	NOUN
gs-4062	941	43	gain	gain	NOUN
gs-4062	941	44	potential	potential	NOUN
gs-4062	941	45	(	(	PUNCT
gs-4062	941	46	e.g.	e.g.	ADV
gs-4062	941	47	,	,	PUNCT
gs-4062	941	48	doravirine	doravirine	ADJ
gs-4062	941	49	)	)	PUNCT
gs-4062	941	50	only	only	ADV
gs-4062	941	51	if	if	SCONJ
gs-4062	941	52	metabolic	metabolic	ADJ
gs-4062	941	53	health	health	NOUN
gs-4062	941	54	is	be	AUX
gs-4062	941	55	significantly	significantly	ADV
gs-4062	941	56	compromised	compromise	VERB
gs-4062	941	57	and	and	CCONJ
gs-4062	941	58	in	in	ADP
gs-4062	941	59	consultation	consultation	NOUN
gs-4062	941	60	with	with	ADP
gs-4062	941	61	the	the	DET
gs-4062	941	62	patient	patient	NOUN
gs-4062	941	63	.	.	PUNCT
gs-4062	942	1	develop	develop	VERB
gs-4062	942	2	and	and	CCONJ
gs-4062	942	3	adhere	adhere	VERB
gs-4062	942	4	to	to	ADP
gs-4062	942	5	strict	strict	ADJ
gs-4062	942	6	clinical	clinical	ADJ
gs-4062	942	7	protocols	protocol	NOUN
gs-4062	942	8	for	for	ADP
gs-4062	942	9	long	long	ADV
gs-4062	942	10	-	-	PUNCT
gs-4062	942	11	acting	act	VERB
gs-4062	942	12	injectable	injectable	ADJ
gs-4062	942	13	therapy	therapy	NOUN
gs-4062	942	14	.	.	PUNCT
gs-4062	943	1	to	to	PART
gs-4062	943	2	ensure	ensure	VERB
gs-4062	943	3	the	the	DET
gs-4062	943	4	success	success	NOUN
gs-4062	943	5	of	of	ADP
gs-4062	943	6	la	la	ADJ
gs-4062	943	7	-	-	NOUN
gs-4062	943	8	art	art	NOUN
gs-4062	943	9	,	,	PUNCT
gs-4062	943	10	clinics	clinic	NOUN
gs-4062	943	11	must	must	AUX
gs-4062	943	12	establish	establish	VERB
gs-4062	943	13	robust	robust	ADJ
gs-4062	943	14	protocols	protocol	NOUN
gs-4062	943	15	.	.	PUNCT
gs-4062	944	1	these	these	PRON
gs-4062	944	2	must	must	AUX
gs-4062	944	3	include	include	VERB
gs-4062	944	4	:	:	PUNCT
gs-4062	944	5	a	a	DET
gs-4062	944	6	mandatory	mandatory	ADJ
gs-4062	944	7	oral	oral	ADJ
gs-4062	944	8	lead	lead	NOUN
gs-4062	944	9	-	-	PUNCT
gs-4062	944	10	in	in	ADP
gs-4062	944	11	phase	phase	NOUN
gs-4062	944	12	to	to	PART
gs-4062	944	13	assess	assess	VERB
gs-4062	944	14	tolerability	tolerability	NOUN
gs-4062	944	15	.	.	PUNCT
gs-4062	945	1	secure	secure	ADJ
gs-4062	945	2	supply	supply	NOUN
gs-4062	945	3	chains	chain	NOUN
gs-4062	945	4	and	and	CCONJ
gs-4062	945	5	scheduling	scheduling	NOUN
gs-4062	945	6	systems	system	NOUN
gs-4062	945	7	to	to	PART
gs-4062	945	8	guarantee	guarantee	VERB
gs-4062	945	9	on	on	ADP
gs-4062	945	10	-	-	PUNCT
gs-4062	945	11	time	time	NOUN
gs-4062	945	12	injections	injection	NOUN
gs-4062	945	13	and	and	CCONJ
gs-4062	945	14	prevent	prevent	VERB
gs-4062	945	15	treatment	treatment	NOUN
gs-4062	945	16	interruptions	interruption	NOUN
gs-4062	945	17	.	.	PUNCT
gs-4062	946	1	comprehensive	comprehensive	ADJ
gs-4062	946	2	patient	patient	ADJ
gs-4062	946	3	education	education	NOUN
gs-4062	946	4	on	on	ADP
gs-4062	946	5	the	the	DET
gs-4062	946	6	importance	importance	NOUN
gs-4062	946	7	of	of	ADP
gs-4062	946	8	injection	injection	NOUN
gs-4062	946	9	adherence	adherence	NOUN
gs-4062	946	10	and	and	CCONJ
gs-4062	946	11	the	the	DET
gs-4062	946	12	risks	risk	NOUN
gs-4062	946	13	of	of	ADP
gs-4062	946	14	the	the	DET
gs-4062	946	15	"	"	PUNCT
gs-4062	946	16	tail	tail	NOUN
gs-4062	946	17	period	period	NOUN
gs-4062	946	18	.	.	PUNCT
gs-4062	946	19	"	"	PUNCT
gs-4062	947	1	a	a	DET
gs-4062	947	2	defined	define	VERB
gs-4062	947	3	plan	plan	NOUN
gs-4062	947	4	for	for	ADP
gs-4062	947	5	rapid	rapid	ADJ
gs-4062	947	6	hiv	hiv	PROPN
gs-4062	947	7	rna	rna	PROPN
gs-4062	947	8	testing	testing	NOUN
gs-4062	947	9	and	and	CCONJ
gs-4062	947	10	resistance	resistance	NOUN
gs-4062	947	11	genotyping	genotyping	NOUN
gs-4062	947	12	at	at	ADP
gs-4062	947	13	any	any	DET
gs-4062	947	14	suspicion	suspicion	NOUN
gs-4062	947	15	of	of	ADP
gs-4062	947	16	breakthrough	breakthrough	ADJ
gs-4062	947	17	infection	infection	NOUN
gs-4062	947	18	during	during	ADP
gs-4062	947	19	the	the	DET
gs-4062	947	20	tail	tail	NOUN
gs-4062	947	21	period	period	NOUN
gs-4062	947	22	to	to	PART
gs-4062	947	23	guide	guide	VERB
gs-4062	947	24	a	a	DET
gs-4062	947	25	fully	fully	ADV
gs-4062	947	26	active	active	ADJ
gs-4062	947	27	salvage	salvage	NOUN
gs-4062	947	28	regimen	regiman	NOUN
gs-4062	947	29	.	.	PUNCT
gs-4062	948	1	integrate	integrate	VERB
gs-4062	948	2	baseline	baseline	NOUN
gs-4062	948	3	resistance	resistance	NOUN
gs-4062	948	4	testing	testing	NOUN
gs-4062	948	5	for	for	ADP
gs-4062	948	6	novel	novel	ADJ
gs-4062	948	7	agents	agent	NOUN
gs-4062	948	8	in	in	ADP
gs-4062	948	9	treatment	treatment	NOUN
gs-4062	948	10	-	-	PUNCT
gs-4062	948	11	experienced	experience	VERB
gs-4062	948	12	patients	patient	NOUN
gs-4062	948	13	.	.	PUNCT
gs-4062	949	1	prior	prior	ADV
gs-4062	949	2	to	to	ADP
gs-4062	949	3	initiating	initiate	VERB
gs-4062	949	4	a	a	DET
gs-4062	949	5	novel	novel	ADJ
gs-4062	949	6	agent	agent	NOUN
gs-4062	949	7	like	like	ADP
gs-4062	949	8	lenacapavir	lenacapavir	NOUN
gs-4062	949	9	or	or	CCONJ
gs-4062	949	10	a	a	DET
gs-4062	949	11	bnab	bnab	NOUN
gs-4062	949	12	in	in	ADP
gs-4062	949	13	a	a	DET
gs-4062	949	14	heavily	heavily	ADV
gs-4062	949	15	treatment	treatment	NOUN
gs-4062	949	16	-	-	PUNCT
gs-4062	949	17	experienced	experience	VERB
gs-4062	949	18	patient	patient	NOUN
gs-4062	949	19	,	,	PUNCT
gs-4062	949	20	baseline	baseline	ADJ
gs-4062	949	21	genotypic	genotypic	NOUN
gs-4062	949	22	and	and	CCONJ
gs-4062	949	23	phenotypic	phenotypic	ADJ
gs-4062	949	24	resistance	resistance	NOUN
gs-4062	949	25	testing	testing	NOUN
gs-4062	949	26	is	be	AUX
gs-4062	949	27	absolutely	absolutely	ADV
gs-4062	949	28	essential	essential	ADJ
gs-4062	949	29	to	to	PART
gs-4062	949	30	ensure	ensure	VERB
gs-4062	949	31	viral	viral	ADJ
gs-4062	949	32	susceptibility	susceptibility	NOUN
gs-4062	949	33	and	and	CCONJ
gs-4062	949	34	maximize	maximize	VERB
gs-4062	949	35	the	the	DET
gs-4062	949	36	drug	drug	NOUN
gs-4062	949	37	's	's	PART
gs-4062	949	38	efficacy	efficacy	NOUN
gs-4062	949	39	.	.	PUNCT
gs-4062	950	1	prioritize	prioritize	VERB
gs-4062	950	2	the	the	DET
gs-4062	950	3	development	development	NOUN
gs-4062	950	4	of	of	ADP
gs-4062	950	5	novel	novel	NOUN
gs-4062	950	6	,	,	PUNCT
gs-4062	950	7	pan	pan	NOUN
gs-4062	950	8	-	-	ADJ
gs-4062	950	9	inhibitory	inhibitory	ADJ
gs-4062	950	10	combinations	combination	NOUN
gs-4062	950	11	.	.	PUNCT
gs-4062	951	1	research	research	NOUN
gs-4062	951	2	and	and	CCONJ
gs-4062	951	3	development	development	NOUN
gs-4062	951	4	must	must	AUX
gs-4062	951	5	focus	focus	VERB
gs-4062	951	6	on	on	ADP
gs-4062	951	7	creating	create	VERB
gs-4062	951	8	co	co	ADJ
gs-4062	951	9	-	-	VERB
gs-4062	951	10	formulated	formulated	ADJ
gs-4062	951	11	,	,	PUNCT
gs-4062	951	12	long	long	ADV
gs-4062	951	13	-	-	PUNCT
gs-4062	951	14	acting	act	VERB
gs-4062	951	15	combinations	combination	NOUN
gs-4062	951	16	that	that	PRON
gs-4062	951	17	target	target	VERB
gs-4062	951	18	multiple	multiple	ADJ
gs-4062	951	19	viral	viral	ADJ
gs-4062	951	20	proteins	protein	NOUN
gs-4062	951	21	georgian	georgian	NOUN
gs-4062	951	22	scientists/	scientists/	NUM
gs-4062	951	23	.	.	PUNCT
gs-4062	952	1	7	7	NUM
gs-4062	952	2	n	n	PRON
gs-4062	952	3	3	3	NUM
gs-4062	952	4	,	,	PUNCT
gs-4062	952	5	2025	2025	NUM
gs-4062	952	6	562	562	NUM
gs-4062	952	7	simultaneously	simultaneously	ADV
gs-4062	952	8	(	(	PUNCT
gs-4062	952	9	e.g.	e.g.	ADV
gs-4062	952	10	,	,	PUNCT
gs-4062	952	11	an	an	DET
gs-4062	952	12	insti	insti	NOUN
gs-4062	952	13	+	+	CCONJ
gs-4062	952	14	a	a	DET
gs-4062	952	15	capsid	capsid	ADJ
gs-4062	952	16	inhibitor	inhibitor	NOUN
gs-4062	952	17	+	+	CCONJ
gs-4062	952	18	a	a	DET
gs-4062	952	19	novel	novel	ADJ
gs-4062	952	20	attachment	attachment	NOUN
gs-4062	952	21	inhibitor	inhibitor	NOUN
gs-4062	952	22	)	)	PUNCT
gs-4062	952	23	.	.	PUNCT
gs-4062	953	1	this	this	DET
gs-4062	953	2	multitarget	multitarget	PROPN
gs-4062	953	3	approach	approach	NOUN
gs-4062	953	4	will	will	AUX
gs-4062	953	5	further	far	ADV
gs-4062	953	6	raise	raise	VERB
gs-4062	953	7	the	the	DET
gs-4062	953	8	genetic	genetic	ADJ
gs-4062	953	9	barrier	barrier	NOUN
gs-4062	953	10	to	to	ADP
gs-4062	953	11	resistance	resistance	NOUN
gs-4062	953	12	and	and	CCONJ
gs-4062	953	13	create	create	VERB
gs-4062	953	14	more	more	ADV
gs-4062	953	15	robust	robust	ADJ
gs-4062	953	16	,	,	PUNCT
gs-4062	953	17	"	"	PUNCT
gs-4062	953	18	resistance	resistance	NOUN
gs-4062	953	19	-	-	PUNCT
gs-4062	953	20	proof	proof	NOUN
gs-4062	953	21	"	"	PUNCT
gs-4062	953	22	regimens	regimen	NOUN
gs-4062	953	23	suitable	suitable	ADJ
gs-4062	953	24	for	for	ADP
gs-4062	953	25	all	all	DET
gs-4062	953	26	populations	population	NOUN
gs-4062	953	27	.	.	PUNCT
gs-4062	954	1	invest	invest	VERB
gs-4062	954	2	heavily	heavily	ADV
gs-4062	954	3	in	in	ADP
gs-4062	954	4	the	the	DET
gs-4062	954	5	development	development	NOUN
gs-4062	954	6	of	of	ADP
gs-4062	954	7	predictive	predictive	ADJ
gs-4062	954	8	biomarkers	biomarker	NOUN
gs-4062	954	9	.	.	PUNCT
gs-4062	955	1	a	a	DET
gs-4062	955	2	major	major	ADJ
gs-4062	955	3	research	research	NOUN
gs-4062	955	4	imperative	imperative	NOUN
gs-4062	955	5	is	be	AUX
gs-4062	955	6	to	to	PART
gs-4062	955	7	identify	identify	VERB
gs-4062	955	8	genetic	genetic	ADJ
gs-4062	955	9	,	,	PUNCT
gs-4062	955	10	metabolic	metabolic	NOUN
gs-4062	955	11	,	,	PUNCT
gs-4062	955	12	or	or	CCONJ
gs-4062	955	13	immunological	immunological	ADJ
gs-4062	955	14	biomarkers	biomarker	NOUN
gs-4062	955	15	that	that	PRON
gs-4062	955	16	can	can	AUX
gs-4062	955	17	predict	predict	VERB
gs-4062	955	18	an	an	DET
gs-4062	955	19	individual	individual	NOUN
gs-4062	955	20	's	's	PART
gs-4062	955	21	risk	risk	NOUN
gs-4062	955	22	of	of	ADP
gs-4062	955	23	specific	specific	ADJ
gs-4062	955	24	adverse	adverse	ADJ
gs-4062	955	25	events	event	NOUN
gs-4062	955	26	,	,	PUNCT
gs-4062	955	27	such	such	ADJ
gs-4062	955	28	as	as	ADP
gs-4062	955	29	weight	weight	NOUN
gs-4062	955	30	gain	gain	NOUN
gs-4062	955	31	or	or	CCONJ
gs-4062	955	32	neuropsychiatric	neuropsychiatric	ADJ
gs-4062	955	33	effects	effect	NOUN
gs-4062	955	34	.	.	PUNCT
gs-4062	956	1	this	this	PRON
gs-4062	956	2	would	would	AUX
gs-4062	956	3	allow	allow	VERB
gs-4062	956	4	for	for	ADP
gs-4062	956	5	truly	truly	ADV
gs-4062	956	6	personalized	personalize	VERB
gs-4062	956	7	medicine	medicine	NOUN
gs-4062	956	8	,	,	PUNCT
gs-4062	956	9	enabling	enable	VERB
gs-4062	956	10	the	the	DET
gs-4062	956	11	selection	selection	NOUN
gs-4062	956	12	of	of	ADP
gs-4062	956	13	the	the	DET
gs-4062	956	14	optimal	optimal	ADJ
gs-4062	956	15	first	first	ADJ
gs-4062	956	16	-	-	PUNCT
gs-4062	956	17	line	line	NOUN
gs-4062	956	18	regimen	regiman	NOUN
gs-4062	956	19	with	with	ADP
gs-4062	956	20	the	the	DET
gs-4062	956	21	lowest	low	ADJ
gs-4062	956	22	probability	probability	NOUN
gs-4062	956	23	of	of	ADP
gs-4062	956	24	side	side	NOUN
gs-4062	956	25	effects	effect	NOUN
gs-4062	956	26	for	for	ADP
gs-4062	956	27	a	a	DET
gs-4062	956	28	given	give	VERB
gs-4062	956	29	patient	patient	NOUN
gs-4062	956	30	.	.	PUNCT
gs-4062	957	1	expand	expand	VERB
gs-4062	957	2	clinical	clinical	ADJ
gs-4062	957	3	trials	trial	NOUN
gs-4062	957	4	to	to	PART
gs-4062	957	5	be	be	AUX
gs-4062	957	6	more	more	ADV
gs-4062	957	7	representative	representative	NOUN
gs-4062	957	8	of	of	ADP
gs-4062	957	9	the	the	DET
gs-4062	957	10	global	global	ADJ
gs-4062	957	11	epidemic	epidemic	NOUN
gs-4062	957	12	.	.	PUNCT
gs-4062	958	1	trial	trial	NOUN
gs-4062	958	2	populations	population	NOUN
gs-4062	958	3	must	must	AUX
gs-4062	958	4	be	be	AUX
gs-4062	958	5	expanded	expand	VERB
gs-4062	958	6	to	to	PART
gs-4062	958	7	include	include	VERB
gs-4062	958	8	more	more	ADJ
gs-4062	958	9	women	woman	NOUN
gs-4062	958	10	,	,	PUNCT
gs-4062	958	11	older	old	ADJ
gs-4062	958	12	individuals	individual	NOUN
gs-4062	958	13	,	,	PUNCT
gs-4062	958	14	and	and	CCONJ
gs-4062	958	15	people	people	NOUN
gs-4062	958	16	with	with	ADP
gs-4062	958	17	non	non	ADJ
gs-4062	958	18	-	-	PROPN
gs-4062	958	19	b	b	ADJ
gs-4062	958	20	hiv	hiv	PROPN
gs-4062	958	21	subtypes	subtype	NOUN
gs-4062	958	22	to	to	PART
gs-4062	958	23	ensure	ensure	VERB
gs-4062	958	24	the	the	DET
gs-4062	958	25	generalizability	generalizability	NOUN
gs-4062	958	26	of	of	ADP
gs-4062	958	27	results	result	NOUN
gs-4062	958	28	.	.	PUNCT
gs-4062	959	1	furthermore	furthermore	ADV
gs-4062	959	2	,	,	PUNCT
gs-4062	959	3	trials	trial	NOUN
gs-4062	959	4	should	should	AUX
gs-4062	959	5	be	be	AUX
gs-4062	959	6	designed	design	VERB
gs-4062	959	7	to	to	PART
gs-4062	959	8	actively	actively	ADV
gs-4062	959	9	include	include	VERB
gs-4062	959	10	populations	population	NOUN
gs-4062	959	11	often	often	ADV
gs-4062	959	12	underrepresented	underrepresente	VERB
gs-4062	959	13	in	in	ADP
gs-4062	959	14	research	research	NOUN
gs-4062	959	15	,	,	PUNCT
gs-4062	959	16	including	include	VERB
gs-4062	959	17	people	people	NOUN
gs-4062	959	18	with	with	ADP
gs-4062	959	19	serious	serious	ADJ
gs-4062	959	20	mental	mental	ADJ
gs-4062	959	21	illness	illness	NOUN
gs-4062	959	22	and	and	CCONJ
gs-4062	959	23	substance	substance	NOUN
gs-4062	959	24	users	user	NOUN
gs-4062	959	25	,	,	PUNCT
gs-4062	959	26	to	to	PART
gs-4062	959	27	understand	understand	VERB
gs-4062	959	28	how	how	SCONJ
gs-4062	959	29	these	these	DET
gs-4062	959	30	therapies	therapy	NOUN
gs-4062	959	31	perform	perform	VERB
gs-4062	959	32	in	in	ADP
gs-4062	959	33	real	real	ADJ
gs-4062	959	34	-	-	PUNCT
gs-4062	959	35	world	world	NOUN
gs-4062	959	36	,	,	PUNCT
gs-4062	959	37	high	high	ADJ
gs-4062	959	38	-	-	PUNCT
gs-4062	959	39	need	need	NOUN
gs-4062	959	40	settings	setting	NOUN
gs-4062	959	41	.	.	PUNCT
gs-4062	960	1	accelerate	accelerate	VERB
gs-4062	960	2	research	research	NOUN
gs-4062	960	3	into	into	ADP
gs-4062	960	4	curative	curative	ADJ
gs-4062	960	5	strategies	strategy	NOUN
gs-4062	960	6	.	.	PUNCT
gs-4062	961	1	the	the	DET
gs-4062	961	2	promising	promising	ADJ
gs-4062	961	3	early	early	ADJ
gs-4062	961	4	results	result	NOUN
gs-4062	961	5	with	with	ADP
gs-4062	961	6	bnabs	bnab	NOUN
gs-4062	961	7	and	and	CCONJ
gs-4062	961	8	gene	gene	NOUN
gs-4062	961	9	therapies	therapy	NOUN
gs-4062	961	10	must	must	AUX
gs-4062	961	11	be	be	AUX
gs-4062	961	12	aggressively	aggressively	ADV
gs-4062	961	13	pursued	pursue	VERB
gs-4062	961	14	.	.	PUNCT
gs-4062	962	1	funding	funding	NOUN
gs-4062	962	2	and	and	CCONJ
gs-4062	962	3	research	research	NOUN
gs-4062	962	4	should	should	AUX
gs-4062	962	5	focus	focus	VERB
gs-4062	962	6	on	on	ADP
gs-4062	962	7	optimizing	optimize	VERB
gs-4062	962	8	"	"	PUNCT
gs-4062	962	9	kickand	kickand	ADJ
gs-4062	962	10	-	-	PUNCT
gs-4062	962	11	kill	kill	NOUN
gs-4062	962	12	"	"	PUNCT
gs-4062	962	13	strategies	strategy	NOUN
gs-4062	962	14	,	,	PUNCT
gs-4062	962	15	combining	combine	VERB
gs-4062	962	16	latency	latency	NOUN
gs-4062	962	17	-	-	PUNCT
gs-4062	962	18	reversing	reverse	VERB
gs-4062	962	19	agents	agent	NOUN
gs-4062	962	20	with	with	ADP
gs-4062	962	21	potent	potent	ADJ
gs-4062	962	22	immune	immune	ADJ
gs-4062	962	23	effectors	effector	NOUN
gs-4062	962	24	,	,	PUNCT
gs-4062	962	25	and	and	CCONJ
gs-4062	962	26	solving	solve	VERB
gs-4062	962	27	the	the	DET
gs-4062	962	28	critical	critical	ADJ
gs-4062	962	29	challenge	challenge	NOUN
gs-4062	962	30	of	of	ADP
gs-4062	962	31	in	in	ADP
gs-4062	962	32	vivo	vivo	ADJ
gs-4062	962	33	delivery	delivery	NOUN
gs-4062	962	34	for	for	ADP
gs-4062	962	35	gene	gene	NOUN
gs-4062	962	36	-	-	PUNCT
gs-4062	962	37	editing	edit	VERB
gs-4062	962	38	technologies	technology	NOUN
gs-4062	962	39	.	.	PUNCT
gs-4062	963	1	aggressively	aggressively	ADV
gs-4062	963	2	pursue	pursue	VERB
gs-4062	963	3	equitable	equitable	ADJ
gs-4062	963	4	access	access	NOUN
gs-4062	963	5	through	through	ADP
gs-4062	963	6	reform	reform	NOUN
gs-4062	963	7	of	of	ADP
gs-4062	963	8	intellectual	intellectual	ADJ
gs-4062	963	9	property	property	NOUN
gs-4062	963	10	and	and	CCONJ
gs-4062	963	11	pricing	pricing	NOUN
gs-4062	963	12	regimes	regime	NOUN
gs-4062	963	13	.	.	PUNCT
gs-4062	964	1	policymakers	policymaker	NOUN
gs-4062	964	2	in	in	ADP
gs-4062	964	3	high	high	ADJ
gs-4062	964	4	-	-	PUNCT
gs-4062	964	5	income	income	NOUN
gs-4062	964	6	countries	country	NOUN
gs-4062	964	7	and	and	CCONJ
gs-4062	964	8	multilateral	multilateral	ADJ
gs-4062	964	9	organizations	organization	NOUN
gs-4062	964	10	must	must	AUX
gs-4062	964	11	champion	champion	VERB
gs-4062	964	12	policies	policy	NOUN
gs-4062	964	13	that	that	PRON
gs-4062	964	14	de	de	NOUN
gs-4062	964	15	-	-	NOUN
gs-4062	964	16	link	link	VERB
gs-4062	964	17	the	the	DET
gs-4062	964	18	cost	cost	NOUN
gs-4062	964	19	of	of	ADP
gs-4062	964	20	r&d	r&d	NOUN
gs-4062	964	21	from	from	ADP
gs-4062	964	22	the	the	DET
gs-4062	964	23	price	price	NOUN
gs-4062	964	24	of	of	ADP
gs-4062	964	25	medicines	medicine	NOUN
gs-4062	964	26	.	.	PUNCT
gs-4062	965	1	this	this	PRON
gs-4062	965	2	includes	include	VERB
gs-4062	965	3	supporting	support	VERB
gs-4062	965	4	mechanisms	mechanism	NOUN
gs-4062	965	5	like	like	ADP
gs-4062	965	6	the	the	DET
gs-4062	965	7	medicines	medicine	NOUN
gs-4062	965	8	patent	patent	NOUN
gs-4062	965	9	pool	pool	NOUN
gs-4062	965	10	to	to	PART
gs-4062	965	11	negotiate	negotiate	VERB
gs-4062	965	12	voluntary	voluntary	ADJ
gs-4062	965	13	licenses	license	NOUN
gs-4062	965	14	for	for	ADP
gs-4062	965	15	new	new	ADJ
gs-4062	965	16	and	and	CCONJ
gs-4062	965	17	future	future	ADJ
gs-4062	965	18	drugs	drug	NOUN
gs-4062	965	19	and	and	CCONJ
gs-4062	965	20	diagnostics	diagnostic	NOUN
gs-4062	965	21	much	much	ADV
gs-4062	965	22	earlier	early	ADV
gs-4062	965	23	in	in	ADP
gs-4062	965	24	their	their	PRON
gs-4062	965	25	product	product	NOUN
gs-4062	965	26	life	life	NOUN
gs-4062	965	27	cycle	cycle	NOUN
gs-4062	965	28	.	.	PUNCT
gs-4062	966	1	governments	government	NOUN
gs-4062	966	2	must	must	AUX
gs-4062	966	3	also	also	ADV
gs-4062	966	4	leverage	leverage	VERB
gs-4062	966	5	their	their	PRON
gs-4062	966	6	purchasing	purchase	VERB
gs-4062	966	7	power	power	NOUN
gs-4062	966	8	to	to	PART
gs-4062	966	9	negotiate	negotiate	VERB
gs-4062	966	10	fair	fair	ADJ
gs-4062	966	11	prices	price	NOUN
gs-4062	966	12	and	and	CCONJ
gs-4062	966	13	support	support	NOUN
gs-4062	966	14	technology	technology	NOUN
gs-4062	966	15	transfer	transfer	NOUN
gs-4062	966	16	to	to	PART
gs-4062	966	17	enable	enable	VERB
gs-4062	966	18	generic	generic	ADJ
gs-4062	966	19	production	production	NOUN
gs-4062	966	20	in	in	ADP
gs-4062	966	21	lmics	lmic	NOUN
gs-4062	966	22	.	.	PUNCT
gs-4062	967	1	fund	fund	NOUN
gs-4062	967	2	and	and	CCONJ
gs-4062	967	3	build	build	VERB
gs-4062	967	4	infrastructure	infrastructure	NOUN
gs-4062	967	5	for	for	ADP
gs-4062	967	6	the	the	DET
gs-4062	967	7	rollout	rollout	NOUN
gs-4062	967	8	of	of	ADP
gs-4062	967	9	long	long	ADV
gs-4062	967	10	-	-	PUNCT
gs-4062	967	11	acting	act	VERB
gs-4062	967	12	therapies	therapy	NOUN
gs-4062	967	13	in	in	ADP
gs-4062	967	14	resource	resource	NOUN
gs-4062	967	15	-	-	PUNCT
gs-4062	967	16	limited	limit	VERB
gs-4062	967	17	settings	setting	NOUN
gs-4062	967	18	.	.	PUNCT
gs-4062	968	1	the	the	DET
gs-4062	968	2	global	global	ADJ
gs-4062	968	3	health	health	PROPN
gs-4062	968	4	community	community	NOUN
gs-4062	968	5	must	must	AUX
gs-4062	968	6	begin	begin	VERB
gs-4062	968	7	planning	plan	VERB
gs-4062	968	8	now	now	ADV
gs-4062	968	9	for	for	ADP
gs-4062	968	10	the	the	DET
gs-4062	968	11	introduction	introduction	NOUN
gs-4062	968	12	of	of	ADP
gs-4062	968	13	la	la	ADJ
gs-4062	968	14	-	-	NOUN
gs-4062	968	15	art	art	NOUN
gs-4062	968	16	in	in	ADP
gs-4062	968	17	lmics	lmic	NOUN
gs-4062	968	18	.	.	PUNCT
gs-4062	969	1	this	this	PRON
gs-4062	969	2	requires	require	VERB
gs-4062	969	3	significant	significant	ADJ
gs-4062	969	4	investment	investment	NOUN
gs-4062	969	5	in	in	ADP
gs-4062	969	6	:	:	PUNCT
gs-4062	969	7	healthcare	healthcare	NOUN
gs-4062	969	8	worker	worker	NOUN
gs-4062	969	9	training	training	NOUN
gs-4062	969	10	for	for	ADP
gs-4062	969	11	injection	injection	NOUN
gs-4062	969	12	administration	administration	NOUN
gs-4062	969	13	.	.	PUNCT
gs-4062	970	1	supply	supply	NOUN
gs-4062	970	2	chain	chain	NOUN
gs-4062	970	3	and	and	CCONJ
gs-4062	970	4	cold	cold	ADJ
gs-4062	970	5	storage	storage	NOUN
gs-4062	970	6	infrastructure	infrastructure	NOUN
gs-4062	970	7	.	.	PUNCT
gs-4062	971	1	laboratory	laboratory	NOUN
gs-4062	971	2	capacity	capacity	NOUN
gs-4062	971	3	for	for	ADP
gs-4062	971	4	enhanced	enhanced	ADJ
gs-4062	971	5	monitoring	monitoring	NOUN
gs-4062	971	6	.	.	PUNCT
gs-4062	972	1	the	the	DET
gs-4062	972	2	development	development	NOUN
gs-4062	972	3	of	of	ADP
gs-4062	972	4	simplified	simplified	ADJ
gs-4062	972	5	,	,	PUNCT
gs-4062	972	6	algorithmic	algorithmic	ADJ
gs-4062	972	7	guidelines	guideline	NOUN
gs-4062	972	8	for	for	ADP
gs-4062	972	9	patient	patient	ADJ
gs-4062	972	10	selection	selection	NOUN
gs-4062	972	11	and	and	CCONJ
gs-4062	972	12	management	management	NOUN
gs-4062	972	13	.	.	PUNCT
gs-4062	973	1	launch	launch	VERB
gs-4062	973	2	ample	ample	ADJ
gs-4062	973	3	implementation	implementation	NOUN
gs-4062	973	4	science	science	NOUN
gs-4062	973	5	research	research	NOUN
gs-4062	973	6	.	.	PUNCT
gs-4062	974	1	before	before	SCONJ
gs-4062	974	2	and	and	CCONJ
gs-4062	974	3	during	during	ADP
gs-4062	974	4	the	the	DET
gs-4062	974	5	scale	scale	NOUN
gs-4062	974	6	-	-	PUNCT
gs-4062	974	7	up	up	NOUN
gs-4062	974	8	of	of	ADP
gs-4062	974	9	new	new	ADJ
gs-4062	974	10	technologies	technology	NOUN
gs-4062	974	11	like	like	ADP
gs-4062	974	12	la	la	ADJ
gs-4062	974	13	-	-	NOUN
gs-4062	974	14	art	art	NOUN
gs-4062	974	15	and	and	CCONJ
gs-4062	974	16	long	long	ADV
gs-4062	974	17	-	-	PUNCT
gs-4062	974	18	acting	act	VERB
gs-4062	974	19	prep	prep	NOUN
gs-4062	974	20	,	,	PUNCT
gs-4062	974	21	dedicated	dedicated	ADJ
gs-4062	974	22	implementation	implementation	NOUN
gs-4062	974	23	science	science	NOUN
gs-4062	974	24	studies	study	NOUN
gs-4062	974	25	are	be	AUX
gs-4062	974	26	crucial	crucial	ADJ
gs-4062	974	27	to	to	PART
gs-4062	974	28	understand	understand	VERB
gs-4062	974	29	the	the	DET
gs-4062	974	30	real	real	ADJ
gs-4062	974	31	-	-	PUNCT
gs-4062	974	32	world	world	NOUN
gs-4062	974	33	barriers	barrier	NOUN
gs-4062	974	34	and	and	CCONJ
gs-4062	974	35	facilitators	facilitator	NOUN
gs-4062	974	36	to	to	ADP
gs-4062	974	37	their	their	PRON
gs-4062	974	38	use	use	NOUN
gs-4062	974	39	in	in	ADP
gs-4062	974	40	diverse	diverse	ADJ
gs-4062	974	41	,	,	PUNCT
gs-4062	974	42	resourceconstrained	resourceconstraine	VERB
gs-4062	974	43	contexts	contexts	NOUN
gs-4062	974	44	.	.	PUNCT
gs-4062	975	1	this	this	DET
gs-4062	975	2	research	research	NOUN
gs-4062	975	3	should	should	AUX
gs-4062	975	4	inform	inform	VERB
gs-4062	975	5	the	the	DET
gs-4062	975	6	adaptation	adaptation	NOUN
gs-4062	975	7	of	of	ADP
gs-4062	975	8	global	global	ADJ
gs-4062	975	9	guidelines	guideline	NOUN
gs-4062	975	10	to	to	ADP
gs-4062	975	11	local	local	ADJ
gs-4062	975	12	realities	reality	NOUN
gs-4062	975	13	.	.	PUNCT
gs-4062	976	1	strengthen	strengthen	VERB
gs-4062	976	2	and	and	CCONJ
gs-4062	976	3	integrate	integrate	VERB
gs-4062	976	4	mental	mental	ADJ
gs-4062	976	5	health	health	NOUN
gs-4062	976	6	and	and	CCONJ
gs-4062	976	7	stigma	stigma	NOUN
gs-4062	976	8	-	-	PUNCT
gs-4062	976	9	reduction	reduction	NOUN
gs-4062	976	10	services	service	NOUN
gs-4062	976	11	.	.	PUNCT
gs-4062	977	1	hiv	hiv	PROPN
gs-4062	977	2	programs	program	NOUN
gs-4062	977	3	must	must	AUX
gs-4062	977	4	be	be	AUX
gs-4062	977	5	funded	fund	VERB
gs-4062	977	6	and	and	CCONJ
gs-4062	977	7	designed	design	VERB
gs-4062	977	8	to	to	PART
gs-4062	977	9	integrate	integrate	VERB
gs-4062	977	10	mental	mental	ADJ
gs-4062	977	11	health	health	NOUN
gs-4062	977	12	support	support	NOUN
gs-4062	977	13	.	.	PUNCT
gs-4062	978	1	the	the	DET
gs-4062	978	2	psychosocial	psychosocial	ADJ
gs-4062	978	3	benefits	benefit	NOUN
gs-4062	978	4	of	of	ADP
gs-4062	978	5	new	new	ADJ
gs-4062	978	6	therapies	therapy	NOUN
gs-4062	978	7	,	,	PUNCT
gs-4062	978	8	like	like	ADP
gs-4062	978	9	the	the	DET
gs-4062	978	10	stigma	stigma	NOUN
gs-4062	978	11	reduction	reduction	NOUN
gs-4062	978	12	associated	associate	VERB
gs-4062	978	13	with	with	ADP
gs-4062	978	14	la	la	NOUN
gs-4062	978	15	-	-	NOUN
gs-4062	978	16	art	art	NOUN
gs-4062	978	17	,	,	PUNCT
gs-4062	978	18	will	will	AUX
gs-4062	978	19	only	only	ADV
gs-4062	978	20	be	be	AUX
gs-4062	978	21	fully	fully	ADV
gs-4062	978	22	realized	realize	VERB
gs-4062	978	23	if	if	SCONJ
gs-4062	978	24	paired	pair	VERB
gs-4062	978	25	with	with	ADP
gs-4062	978	26	counseling	counseling	NOUN
gs-4062	978	27	and	and	CCONJ
gs-4062	978	28	support	support	NOUN
gs-4062	978	29	services	service	NOUN
gs-4062	978	30	that	that	PRON
gs-4062	978	31	address	address	VERB
gs-4062	978	32	the	the	DET
gs-4062	978	33	deep	deep	ADV
gs-4062	978	34	-	-	PUNCT
gs-4062	978	35	seated	seat	VERB
gs-4062	978	36	trauma	trauma	NOUN
gs-4062	978	37	and	and	CCONJ
gs-4062	978	38	stigma	stigma	NOUN
gs-4062	978	39	associated	associate	VERB
gs-4062	978	40	with	with	ADP
gs-4062	978	41	an	an	DET
gs-4062	978	42	hiv	hiv	NOUN
gs-4062	978	43	diagnosis	diagnosis	NOUN
gs-4062	978	44	.	.	PUNCT
gs-4062	979	1	demand	demand	VERB
gs-4062	979	2	a	a	DET
gs-4062	979	3	seat	seat	NOUN
gs-4062	979	4	at	at	ADP
gs-4062	979	5	the	the	DET
gs-4062	979	6	table	table	NOUN
gs-4062	979	7	in	in	ADP
gs-4062	979	8	drug	drug	NOUN
gs-4062	979	9	development	development	NOUN
gs-4062	979	10	and	and	CCONJ
gs-4062	979	11	policy	policy	NOUN
gs-4062	979	12	design	design	NOUN
gs-4062	979	13	.	.	PUNCT
gs-4062	980	1	patient	patient	ADJ
gs-4062	980	2	advocacy	advocacy	NOUN
gs-4062	980	3	groups	group	NOUN
gs-4062	980	4	must	must	AUX
gs-4062	980	5	be	be	AUX
gs-4062	980	6	meaningfully	meaningfully	ADV
gs-4062	980	7	involved	involve	VERB
gs-4062	980	8	from	from	ADP
gs-4062	980	9	the	the	DET
gs-4062	980	10	earliest	early	ADJ
gs-4062	980	11	stages	stage	NOUN
gs-4062	980	12	of	of	ADP
gs-4062	980	13	clinical	clinical	ADJ
gs-4062	980	14	trial	trial	NOUN
gs-4062	980	15	design	design	NOUN
gs-4062	980	16	through	through	ADP
gs-4062	980	17	to	to	ADP
gs-4062	980	18	national	national	ADJ
gs-4062	980	19	policy	policy	NOUN
gs-4062	980	20	georgian	georgian	NOUN
gs-4062	980	21	scientists/	scientists/	NUM
gs-4062	980	22	.	.	PUNCT
gs-4062	981	1	7	7	NUM
gs-4062	981	2	n	n	PRON
gs-4062	981	3	3	3	NUM
gs-4062	981	4	,	,	PUNCT
gs-4062	981	5	2025	2025	NUM
gs-4062	981	6	563	563	NUM
gs-4062	981	7	formulation	formulation	NOUN
gs-4062	981	8	.	.	PUNCT
gs-4062	982	1	their	their	PRON
gs-4062	982	2	lived	live	VERB
gs-4062	982	3	experience	experience	NOUN
gs-4062	982	4	is	be	AUX
gs-4062	982	5	critical	critical	ADJ
gs-4062	982	6	for	for	ADP
gs-4062	982	7	defining	define	VERB
gs-4062	982	8	meaningful	meaningful	ADJ
gs-4062	982	9	trial	trial	NOUN
gs-4062	982	10	endpoints	endpoint	NOUN
gs-4062	982	11	,	,	PUNCT
gs-4062	982	12	designing	design	VERB
gs-4062	982	13	patient	patient	NOUN
gs-4062	982	14	-	-	PUNCT
gs-4062	982	15	friendly	friendly	ADJ
gs-4062	982	16	regimens	regimen	NOUN
gs-4062	982	17	,	,	PUNCT
gs-4062	982	18	and	and	CCONJ
gs-4062	982	19	creating	create	VERB
gs-4062	982	20	policies	policy	NOUN
gs-4062	982	21	that	that	PRON
gs-4062	982	22	are	be	AUX
gs-4062	982	23	truly	truly	ADV
gs-4062	982	24	responsive	responsive	ADJ
gs-4062	982	25	to	to	ADP
gs-4062	982	26	patient	patient	NOUN
gs-4062	982	27	needs	need	NOUN
gs-4062	982	28	.	.	PUNCT
gs-4062	983	1	advocate	advocate	VERB
gs-4062	983	2	for	for	ADP
gs-4062	983	3	transparency	transparency	NOUN
gs-4062	983	4	and	and	CCONJ
gs-4062	983	5	accountability	accountability	NOUN
gs-4062	983	6	.	.	PUNCT
gs-4062	984	1	communities	community	NOUN
gs-4062	984	2	should	should	AUX
gs-4062	984	3	demand	demand	VERB
gs-4062	984	4	transparency	transparency	NOUN
gs-4062	984	5	from	from	ADP
gs-4062	984	6	pharmaceutical	pharmaceutical	ADJ
gs-4062	984	7	companies	company	NOUN
gs-4062	984	8	on	on	ADP
gs-4062	984	9	r&d	r&d	NOUN
gs-4062	984	10	costs	cost	NOUN
gs-4062	984	11	and	and	CCONJ
gs-4062	984	12	pricing	pricing	NOUN
gs-4062	984	13	models	model	NOUN
gs-4062	984	14	and	and	CCONJ
gs-4062	984	15	hold	hold	VERB
gs-4062	984	16	governments	government	NOUN
gs-4062	984	17	and	and	CCONJ
gs-4062	984	18	global	global	ADJ
gs-4062	984	19	health	health	NOUN
gs-4062	984	20	institutions	institution	NOUN
gs-4062	984	21	accountable	accountable	ADJ
gs-4062	984	22	for	for	ADP
gs-4062	984	23	their	their	PRON
gs-4062	984	24	commitments	commitment	NOUN
gs-4062	984	25	to	to	ADP
gs-4062	984	26	health	health	NOUN
gs-4062	984	27	equity	equity	NOUN
gs-4062	984	28	and	and	CCONJ
gs-4062	984	29	the	the	DET
gs-4062	984	30	right	right	NOUN
gs-4062	984	31	to	to	ADP
gs-4062	984	32	health	health	NOUN
gs-4062	984	33	.	.	PUNCT
gs-4062	985	1	the	the	DET
gs-4062	985	2	new	new	ADJ
gs-4062	985	3	generation	generation	NOUN
gs-4062	985	4	of	of	ADP
gs-4062	985	5	antiretrovirals	antiretroviral	NOUN
gs-4062	985	6	provides	provide	VERB
gs-4062	985	7	the	the	DET
gs-4062	985	8	tools	tool	NOUN
gs-4062	985	9	to	to	PART
gs-4062	985	10	not	not	PART
gs-4062	985	11	only	only	ADV
gs-4062	985	12	manage	manage	VERB
gs-4062	985	13	hiv	hiv	PROPN
gs-4062	985	14	but	but	CCONJ
gs-4062	985	15	to	to	PART
gs-4062	985	16	fundamentally	fundamentally	ADV
gs-4062	985	17	transform	transform	VERB
gs-4062	985	18	the	the	DET
gs-4062	985	19	experience	experience	NOUN
gs-4062	985	20	of	of	ADP
gs-4062	985	21	living	live	VERB
gs-4062	985	22	with	with	ADP
gs-4062	985	23	the	the	DET
gs-4062	985	24	virus	virus	NOUN
gs-4062	985	25	.	.	PUNCT
gs-4062	986	1	these	these	DET
gs-4062	986	2	recommendations	recommendation	NOUN
gs-4062	986	3	provide	provide	VERB
gs-4062	986	4	a	a	DET
gs-4062	986	5	roadmap	roadmap	NOUN
gs-4062	986	6	for	for	ADP
gs-4062	986	7	harnessing	harness	VERB
gs-4062	986	8	this	this	DET
gs-4062	986	9	potential	potential	NOUN
gs-4062	986	10	.	.	PUNCT
gs-4062	987	1	by	by	ADP
gs-4062	987	2	embracing	embrace	VERB
gs-4062	987	3	personalized	personalized	ADJ
gs-4062	987	4	care	care	NOUN
gs-4062	987	5	,	,	PUNCT
gs-4062	987	6	prioritizing	prioritize	VERB
gs-4062	987	7	equitable	equitable	ADJ
gs-4062	987	8	access	access	NOUN
gs-4062	987	9	,	,	PUNCT
gs-4062	987	10	and	and	CCONJ
gs-4062	987	11	relentlessly	relentlessly	ADV
gs-4062	987	12	pursuing	pursue	VERB
gs-4062	987	13	innovation	innovation	NOUN
gs-4062	987	14	,	,	PUNCT
gs-4062	987	15	the	the	DET
gs-4062	987	16	global	global	ADJ
gs-4062	987	17	community	community	NOUN
gs-4062	987	18	can	can	AUX
gs-4062	987	19	ensure	ensure	VERB
gs-4062	987	20	that	that	SCONJ
gs-4062	987	21	this	this	DET
gs-4062	987	22	scientific	scientific	ADJ
gs-4062	987	23	revolution	revolution	NOUN
gs-4062	987	24	translates	translate	VERB
gs-4062	987	25	into	into	ADP
gs-4062	987	26	a	a	DET
gs-4062	987	27	lasting	last	VERB
gs-4062	987	28	and	and	CCONJ
gs-4062	987	29	just	just	ADV
gs-4062	987	30	end	end	VERB
gs-4062	987	31	to	to	ADP
gs-4062	987	32	the	the	DET
gs-4062	987	33	aids	aids	PROPN
gs-4062	987	34	epidemic	epidemic	NOUN
gs-4062	987	35	for	for	ADP
gs-4062	987	36	all	all	PRON
gs-4062	987	37	.	.	PUNCT
gs-4062	988	1	references	reference	NOUN
gs-4062	988	2	1	1	NUM
gs-4062	988	3	.	.	PUNCT
gs-4062	988	4	world	world	PROPN
gs-4062	988	5	health	health	PROPN
gs-4062	988	6	organization	organization	PROPN
gs-4062	988	7	.	.	PUNCT
gs-4062	989	1	updated	update	VERB
gs-4062	989	2	recommendations	recommendation	NOUN
gs-4062	989	3	on	on	ADP
gs-4062	989	4	first	first	ADJ
gs-4062	989	5	-	-	PUNCT
gs-4062	989	6	line	line	NOUN
gs-4062	989	7	and	and	CCONJ
gs-4062	989	8	second	second	ADJ
gs-4062	989	9	-	-	PUNCT
gs-4062	989	10	line	line	NOUN
gs-4062	989	11	antiretroviral	antiretroviral	ADJ
gs-4062	989	12	regimens	regimen	NOUN
gs-4062	989	13	and	and	CCONJ
gs-4062	989	14	post	post	ADJ
gs-4062	989	15	-	-	ADJ
gs-4062	989	16	exposure	exposure	ADJ
gs-4062	989	17	prophylaxis	prophylaxis	NOUN
gs-4062	989	18	and	and	CCONJ
gs-4062	989	19	recommendations	recommendation	NOUN
gs-4062	989	20	on	on	ADP
gs-4062	989	21	early	early	ADJ
gs-4062	989	22	infant	infant	NOUN
gs-4062	989	23	diagnosis	diagnosis	NOUN
gs-4062	989	24	of	of	ADP
gs-4062	989	25	hiv	hiv	PROPN
gs-4062	989	26	:	:	PUNCT
gs-4062	989	27	supplement	supplement	NOUN
gs-4062	989	28	to	to	ADP
gs-4062	989	29	the	the	DET
gs-4062	989	30	2016	2016	NUM
gs-4062	989	31	consolidated	consolidated	ADJ
gs-4062	989	32	guidelines	guideline	NOUN
gs-4062	989	33	on	on	ADP
gs-4062	989	34	the	the	DET
gs-4062	989	35	use	use	NOUN
gs-4062	989	36	of	of	ADP
gs-4062	989	37	antiretroviral	antiretroviral	ADJ
gs-4062	989	38	drugs	drug	NOUN
gs-4062	989	39	for	for	ADP
gs-4062	989	40	treating	treat	VERB
gs-4062	989	41	and	and	CCONJ
gs-4062	989	42	preventing	prevent	VERB
gs-4062	989	43	hiv	hiv	PROPN
gs-4062	989	44	infection	infection	NOUN
gs-4062	989	45	.	.	PUNCT
gs-4062	990	1	geneva	geneva	PROPN
gs-4062	990	2	:	:	PUNCT
gs-4062	990	3	world	world	PROPN
gs-4062	990	4	health	health	NOUN
gs-4062	990	5	organization	organization	NOUN
gs-4062	990	6	;	;	PUNCT
gs-4062	990	7	2018	2018	NUM
gs-4062	990	8	.	.	X
gs-4062	991	1	2	2	X
gs-4062	991	2	.	.	X
gs-4062	991	3	panel	panel	NOUN
gs-4062	991	4	on	on	ADP
gs-4062	991	5	antiretroviral	antiretroviral	ADJ
gs-4062	991	6	guidelines	guideline	NOUN
gs-4062	991	7	for	for	ADP
gs-4062	991	8	adults	adult	NOUN
gs-4062	991	9	and	and	CCONJ
gs-4062	991	10	adolescents	adolescent	NOUN
gs-4062	991	11	.	.	PUNCT
gs-4062	992	1	guidelines	guideline	NOUN
gs-4062	992	2	for	for	ADP
gs-4062	992	3	the	the	DET
gs-4062	992	4	use	use	NOUN
gs-4062	992	5	of	of	ADP
gs-4062	992	6	antiretroviral	antiretroviral	ADJ
gs-4062	992	7	agents	agent	NOUN
gs-4062	992	8	in	in	ADP
gs-4062	992	9	adults	adult	NOUN
gs-4062	992	10	and	and	CCONJ
gs-4062	992	11	adolescents	adolescent	NOUN
gs-4062	992	12	with	with	ADP
gs-4062	992	13	hiv	hiv	PROPN
gs-4062	992	14	.	.	PUNCT
gs-4062	993	1	department	department	PROPN
gs-4062	993	2	of	of	ADP
gs-4062	993	3	health	health	PROPN
gs-4062	993	4	and	and	CCONJ
gs-4062	993	5	human	human	ADJ
gs-4062	993	6	services	service	NOUN
gs-4062	993	7	.	.	PUNCT
gs-4062	994	1	[	[	X
gs-4062	994	2	online	online	X
gs-4062	994	3	]	]	X
gs-4062	994	4	.	.	PUNCT
gs-4062	995	1	2023	2023	NUM
gs-4062	995	2	.	.	PUNCT
gs-4062	996	1	available	available	ADJ
gs-4062	996	2	from	from	ADP
gs-4062	996	3	:	:	PUNCT
gs-4062	996	4	https://clinicalinfo.hiv.gov/en/guidelines/adult-andadolescent-arv	https://clinicalinfo.hiv.gov/en/guidelines/adult-andadolescent-arv	PROPN
gs-4062	996	5	3	3	NUM
gs-4062	996	6	.	.	X
gs-4062	996	7	de	de	PROPN
gs-4062	996	8	clercq	clercq	PROPN
gs-4062	996	9	e.	e.	PROPN
gs-4062	997	1	the	the	DET
gs-4062	997	2	history	history	NOUN
gs-4062	997	3	of	of	ADP
gs-4062	997	4	antiretrovirals	antiretroviral	NOUN
gs-4062	997	5	:	:	PUNCT
gs-4062	997	6	key	key	ADJ
gs-4062	997	7	discoveries	discovery	NOUN
gs-4062	997	8	over	over	ADP
gs-4062	997	9	the	the	DET
gs-4062	997	10	past	past	ADJ
gs-4062	997	11	25	25	NUM
gs-4062	997	12	years	year	NOUN
gs-4062	997	13	.	.	PUNCT
gs-4062	998	1	rev	rev	PROPN
gs-4062	998	2	med	med	PROPN
gs-4062	998	3	virol	virol	NOUN
gs-4062	998	4	.	.	PUNCT
gs-4062	999	1	2009	2009	NUM
gs-4062	999	2	sep	sep	PROPN
gs-4062	999	3	-	-	PUNCT
gs-4062	999	4	oct;19(5):287	oct;19(5):287	ADP
gs-4062	999	5	-	-	PUNCT
gs-4062	999	6	99	99	NUM
gs-4062	999	7	.	.	NOUN
gs-4062	1000	1	4	4	NUM
gs-4062	1000	2	.	.	NOUN
gs-4062	1000	3	flexner	flexner	PROPN
gs-4062	1000	4	c.	c.	PROPN
gs-4062	1000	5	hiv	hiv	PROPN
gs-4062	1000	6	drug	drug	PROPN
gs-4062	1000	7	development	development	NOUN
gs-4062	1000	8	:	:	PUNCT
gs-4062	1000	9	the	the	DET
gs-4062	1000	10	next	next	ADJ
gs-4062	1000	11	25	25	NUM
gs-4062	1000	12	years	year	NOUN
gs-4062	1000	13	.	.	PUNCT
gs-4062	1001	1	nat	nat	PROPN
gs-4062	1001	2	rev	rev	VERB
gs-4062	1001	3	drug	drug	NOUN
gs-4062	1001	4	discov	discov	NOUN
gs-4062	1001	5	.	.	PUNCT
gs-4062	1002	1	2007	2007	NUM
gs-4062	1002	2	dec;6(12):95966	dec;6(12):95966	NOUN
gs-4062	1002	3	.	.	PUNCT
gs-4062	1003	1	5	5	NUM
gs-4062	1003	2	.	.	X
gs-4062	1003	3	wensing	wense	VERB
gs-4062	1003	4	am	be	AUX
gs-4062	1003	5	,	,	PUNCT
gs-4062	1003	6	calvez	calvez	ADJ
gs-4062	1003	7	v	v	NOUN
gs-4062	1003	8	,	,	PUNCT
gs-4062	1003	9	ceccherini	ceccherini	NOUN
gs-4062	1003	10	-	-	PUNCT
gs-4062	1003	11	silberstein	silberstein	NOUN
gs-4062	1003	12	f	f	PROPN
gs-4062	1003	13	,	,	PUNCT
gs-4062	1003	14	charpentier	charpentier	PROPN
gs-4062	1003	15	c	c	PROPN
gs-4062	1003	16	,	,	PUNCT
gs-4062	1003	17	günthard	günthard	ADJ
gs-4062	1003	18	hf	hf	PROPN
gs-4062	1003	19	,	,	PUNCT
gs-4062	1003	20	paredes	paredes	PROPN
gs-4062	1003	21	r	r	NOUN
gs-4062	1003	22	,	,	PUNCT
gs-4062	1003	23	et	et	PROPN
gs-4062	1003	24	al	al	PROPN
gs-4062	1003	25	.	.	PROPN
gs-4062	1003	26	2022	2022	NUM
gs-4062	1003	27	update	update	NOUN
gs-4062	1003	28	of	of	ADP
gs-4062	1003	29	the	the	DET
gs-4062	1003	30	drug	drug	NOUN
gs-4062	1003	31	resistance	resistance	NOUN
gs-4062	1003	32	mutations	mutation	NOUN
gs-4062	1003	33	in	in	ADP
gs-4062	1003	34	hiv-1	hiv-1	ADJ
gs-4062	1003	35	.	.	PUNCT
gs-4062	1004	1	top	top	ADJ
gs-4062	1004	2	antivir	antivir	PROPN
gs-4062	1004	3	med	med	PROPN
gs-4062	1004	4	.	.	PUNCT
gs-4062	1004	5	2022	2022	NUM
gs-4062	1005	1	oct;30(4):559574	oct;30(4):559574	PROPN
gs-4062	1005	2	.	.	PROPN
gs-4062	1005	3	6	6	NUM
gs-4062	1005	4	.	.	X
gs-4062	1005	5	menéndez	menéndez	ADJ
gs-4062	1005	6	-	-	PUNCT
gs-4062	1005	7	arias	arias	PROPN
gs-4062	1005	8	l	l	NOUN
gs-4062	1005	9	,	,	PUNCT
gs-4062	1005	10	delgado	delgado	VERB
gs-4062	1005	11	r.	r.	NOUN
gs-4062	1005	12	update	update	NOUN
gs-4062	1005	13	and	and	CCONJ
gs-4062	1005	14	latest	late	ADJ
gs-4062	1005	15	advances	advance	NOUN
gs-4062	1005	16	in	in	ADP
gs-4062	1005	17	antiretroviral	antiretroviral	ADJ
gs-4062	1005	18	therapy	therapy	NOUN
gs-4062	1005	19	.	.	PUNCT
gs-4062	1006	1	trends	trend	NOUN
gs-4062	1006	2	pharmacol	pharmacol	PROPN
gs-4062	1006	3	sci	sci	PROPN
gs-4062	1006	4	.	.	PROPN
gs-4062	1006	5	2022	2022	NUM
gs-4062	1006	6	jan;43(1):16	jan;43(1):16	NOUN
gs-4062	1006	7	-	-	PUNCT
gs-4062	1006	8	29	29	NUM
gs-4062	1006	9	.	.	PUNCT
gs-4062	1007	1	7	7	X
gs-4062	1007	2	.	.	X
gs-4062	1007	3	cihlar	cihlar	PROPN
gs-4062	1007	4	t	t	PROPN
gs-4062	1007	5	,	,	PUNCT
gs-4062	1007	6	fordyce	fordyce	PROPN
gs-4062	1007	7	m.	m.	PROPN
gs-4062	1007	8	current	current	ADJ
gs-4062	1007	9	status	status	NOUN
gs-4062	1007	10	and	and	CCONJ
gs-4062	1007	11	prospects	prospect	NOUN
gs-4062	1007	12	of	of	ADP
gs-4062	1007	13	hiv	hiv	PROPN
gs-4062	1007	14	treatment	treatment	NOUN
gs-4062	1007	15	.	.	PUNCT
gs-4062	1008	1	curr	curr	PROPN
gs-4062	1008	2	opin	opin	NOUN
gs-4062	1008	3	virol	virol	NOUN
gs-4062	1008	4	.	.	PUNCT
gs-4062	1009	1	2016	2016	NUM
gs-4062	1009	2	jun;18:50	jun;18:50	PROPN
gs-4062	1009	3	-	-	PUNCT
gs-4062	1009	4	6	6	NUM
gs-4062	1009	5	.	.	NOUN
gs-4062	1009	6	8	8	NUM
gs-4062	1009	7	.	.	X
gs-4062	1010	1	tsiang	tsiang	PROPN
gs-4062	1010	2	m	m	PROPN
gs-4062	1010	3	,	,	PUNCT
gs-4062	1010	4	jones	jones	PROPN
gs-4062	1010	5	gs	gs	PROPN
gs-4062	1010	6	,	,	PUNCT
gs-4062	1010	7	goldsmith	goldsmith	PROPN
gs-4062	1010	8	j	j	PROPN
gs-4062	1010	9	,	,	PUNCT
gs-4062	1010	10	mulato	mulato	X
gs-4062	1010	11	a	a	X
gs-4062	1010	12	,	,	PUNCT
gs-4062	1010	13	hansen	hansen	PROPN
gs-4062	1010	14	d	d	PROPN
gs-4062	1010	15	,	,	PUNCT
gs-4062	1010	16	kan	kan	PROPN
gs-4062	1010	17	e	e	PROPN
gs-4062	1010	18	,	,	PUNCT
gs-4062	1010	19	et	et	PROPN
gs-4062	1010	20	al	al	PROPN
gs-4062	1010	21	.	.	PUNCT
gs-4062	1011	1	antiviral	antiviral	ADJ
gs-4062	1011	2	activity	activity	NOUN
gs-4062	1011	3	of	of	ADP
gs-4062	1011	4	bictegravir	bictegravir	PROPN
gs-4062	1011	5	(	(	PUNCT
gs-4062	1011	6	gs-9883	gs-9883	NOUN
gs-4062	1011	7	)	)	PUNCT
gs-4062	1011	8	,	,	PUNCT
gs-4062	1011	9	a	a	DET
gs-4062	1011	10	novel	novel	NOUN
gs-4062	1011	11	potent	potent	NOUN
gs-4062	1011	12	hiv-1	hiv-1	X
gs-4062	1011	13	integrase	integrase	NOUN
gs-4062	1011	14	strand	strand	NOUN
gs-4062	1011	15	transfer	transfer	NOUN
gs-4062	1011	16	inhibitor	inhibitor	NOUN
gs-4062	1011	17	with	with	ADP
gs-4062	1011	18	an	an	DET
gs-4062	1011	19	improved	improved	ADJ
gs-4062	1011	20	resistance	resistance	NOUN
gs-4062	1011	21	profile	profile	NOUN
gs-4062	1011	22	.	.	PUNCT
gs-4062	1012	1	antimicrob	antimicrob	PROPN
gs-4062	1012	2	agents	agents	PROPN
gs-4062	1012	3	chemother	chemother	PROPN
gs-4062	1012	4	.	.	PUNCT
gs-4062	1013	1	2016	2016	NUM
gs-4062	1013	2	jul	jul	PROPN
gs-4062	1013	3	22;60(12):7086	22;60(12):7086	NUM
gs-4062	1013	4	-	-	SYM
gs-4062	1013	5	97	97	NUM
gs-4062	1013	6	.	.	NOUN
gs-4062	1013	7	9	9	NUM
gs-4062	1013	8	.	.	PUNCT
gs-4062	1014	1	markham	markham	PROPN
gs-4062	1014	2	a.	a.	PROPN
gs-4062	1014	3	cabotegravir	cabotegravir	PROPN
gs-4062	1014	4	plus	plus	CCONJ
gs-4062	1014	5	rilpivirine	rilpivirine	VERB
gs-4062	1014	6	:	:	PUNCT
gs-4062	1014	7	first	first	ADJ
gs-4062	1014	8	approval	approval	NOUN
gs-4062	1014	9	.	.	PUNCT
gs-4062	1015	1	drugs	drug	NOUN
gs-4062	1015	2	.	.	PUNCT
gs-4062	1016	1	2020	2020	NUM
gs-4062	1017	1	may;80(9):915	may;80(9):915	NOUN
gs-4062	1017	2	-	-	SYM
gs-4062	1017	3	922	922	NUM
gs-4062	1017	4	.	.	PUNCT
gs-4062	1018	1	10	10	NUM
gs-4062	1018	2	.	.	PUNCT
gs-4062	1019	1	scott	scott	PROPN
gs-4062	1019	2	lj	lj	PROPN
gs-4062	1019	3	.	.	PUNCT
gs-4062	1020	1	fostemsavir	fostemsavir	PROPN
gs-4062	1020	2	:	:	PUNCT
gs-4062	1020	3	first	first	ADJ
gs-4062	1020	4	approval	approval	NOUN
gs-4062	1020	5	.	.	PUNCT
gs-4062	1021	1	drugs	drug	NOUN
gs-4062	1021	2	.	.	PUNCT
gs-4062	1022	1	2020	2020	NUM
gs-4062	1022	2	sep;80(14):1485	sep;80(14):1485	NOUN
gs-4062	1022	3	-	-	PUNCT
gs-4062	1022	4	1490	1490	NUM
gs-4062	1022	5	.	.	PUNCT
gs-4062	1023	1	11	11	NUM
gs-4062	1023	2	.	.	PUNCT
gs-4062	1024	1	kozal	kozal	PROPN
gs-4062	1024	2	m	m	PROPN
gs-4062	1024	3	,	,	PUNCT
gs-4062	1024	4	aberg	aberg	PROPN
gs-4062	1024	5	j	j	PROPN
gs-4062	1024	6	,	,	PUNCT
gs-4062	1024	7	pialoux	pialoux	NOUN
gs-4062	1024	8	g	g	PROPN
gs-4062	1024	9	,	,	PUNCT
gs-4062	1024	10	cahn	cahn	NOUN
gs-4062	1024	11	p	p	X
gs-4062	1024	12	,	,	PUNCT
gs-4062	1024	13	thompson	thompson	PROPN
gs-4062	1024	14	m	m	PROPN
gs-4062	1024	15	,	,	PUNCT
gs-4062	1024	16	molina	molina	PROPN
gs-4062	1024	17	jm	jm	PROPN
gs-4062	1024	18	,	,	PUNCT
gs-4062	1024	19	et	et	PROPN
gs-4062	1024	20	al	al	PROPN
gs-4062	1024	21	.	.	PROPN
gs-4062	1024	22	fostemsavir	fostemsavir	PROPN
gs-4062	1024	23	in	in	ADP
gs-4062	1024	24	adults	adult	NOUN
gs-4062	1024	25	with	with	ADP
gs-4062	1024	26	multidrug	multidrug	NOUN
gs-4062	1024	27	-	-	PUNCT
gs-4062	1024	28	resistant	resistant	ADJ
gs-4062	1024	29	hiv-1	hiv-1	ADJ
gs-4062	1024	30	infection	infection	NOUN
gs-4062	1024	31	.	.	PUNCT
gs-4062	1025	1	n	n	PROPN
gs-4062	1025	2	engl	engl	PROPN
gs-4062	1025	3	j	j	PROPN
gs-4062	1025	4	med	med	PROPN
gs-4062	1025	5	.	.	PUNCT
gs-4062	1026	1	2020	2020	NUM
gs-4062	1026	2	mar	mar	PROPN
gs-4062	1026	3	26;382(13):1232	26;382(13):1232	PROPN
gs-4062	1026	4	-	-	PUNCT
gs-4062	1026	5	1243	1243	NUM
gs-4062	1026	6	.	.	PUNCT
gs-4062	1027	1	12	12	NUM
gs-4062	1027	2	.	.	PUNCT
gs-4062	1028	1	emu	emu	PROPN
gs-4062	1028	2	b	b	PROPN
gs-4062	1028	3	,	,	PUNCT
gs-4062	1028	4	fessel	fessel	PROPN
gs-4062	1028	5	j	j	PROPN
gs-4062	1028	6	,	,	PUNCT
gs-4062	1028	7	schrader	schrader	PROPN
gs-4062	1028	8	s	s	PROPN
gs-4062	1028	9	,	,	PUNCT
gs-4062	1028	10	kumar	kumar	PROPN
gs-4062	1028	11	p	p	PROPN
gs-4062	1028	12	,	,	PUNCT
gs-4062	1028	13	richmond	richmond	PROPN
gs-4062	1028	14	g	g	PROPN
gs-4062	1028	15	,	,	PUNCT
gs-4062	1028	16	win	win	VERB
gs-4062	1028	17	s	s	PART
gs-4062	1028	18	,	,	PUNCT
gs-4062	1028	19	et	et	PROPN
gs-4062	1028	20	al	al	PROPN
gs-4062	1028	21	.	.	PROPN
gs-4062	1028	22	phase	phase	NOUN
gs-4062	1028	23	3	3	NUM
gs-4062	1028	24	study	study	NOUN
gs-4062	1028	25	of	of	ADP
gs-4062	1028	26	ibalizumab	ibalizumab	NOUN
gs-4062	1028	27	for	for	ADP
gs-4062	1028	28	multidrug	multidrug	NOUN
gs-4062	1028	29	-	-	PUNCT
gs-4062	1028	30	resistant	resistant	ADJ
gs-4062	1028	31	hiv-1	hiv-1	ADJ
gs-4062	1028	32	.	.	PUNCT
gs-4062	1029	1	n	n	PRON
gs-4062	1029	2	engl	engl	PROPN
gs-4062	1029	3	j	j	PROPN
gs-4062	1029	4	med	med	PROPN
gs-4062	1029	5	.	.	PUNCT
gs-4062	1030	1	2018	2018	NUM
gs-4062	1030	2	aug	aug	PROPN
gs-4062	1030	3	16;379(7):645	16;379(7):645	NUM
gs-4062	1030	4	-	-	SYM
gs-4062	1030	5	654	654	NUM
gs-4062	1030	6	.	.	PUNCT
gs-4062	1030	7	13	13	NUM
gs-4062	1030	8	.	.	PUNCT
gs-4062	1031	1	lataillade	lataillade	PROPN
gs-4062	1031	2	m	m	PROPN
gs-4062	1031	3	,	,	PUNCT
gs-4062	1031	4	kozal	kozal	PROPN
gs-4062	1031	5	mj	mj	PROPN
gs-4062	1031	6	.	.	PUNCT
gs-4062	1032	1	the	the	DET
gs-4062	1032	2	hunt	hunt	NOUN
gs-4062	1032	3	for	for	ADP
gs-4062	1032	4	hiv-1	hiv-1	PUNCT
gs-4062	1032	5	latency	latency	NOUN
gs-4062	1032	6	drugs	drug	NOUN
gs-4062	1032	7	.	.	PUNCT
gs-4062	1033	1	lancet	lancet	PROPN
gs-4062	1033	2	hiv	hiv	PROPN
gs-4062	1033	3	.	.	PUNCT
gs-4062	1034	1	2016	2016	NUM
gs-4062	1034	2	nov;3(11):e504e506	nov;3(11):e504e506	NOUN
gs-4062	1034	3	.	.	PROPN
gs-4062	1034	4	14	14	NUM
gs-4062	1034	5	.	.	PUNCT
gs-4062	1035	1	margolis	margolis	PROPN
gs-4062	1035	2	am	be	AUX
gs-4062	1035	3	,	,	PUNCT
gs-4062	1035	4	heverling	heverle	VERB
gs-4062	1035	5	h	h	PROPN
gs-4062	1035	6	,	,	PUNCT
gs-4062	1035	7	pham	pham	PROPN
gs-4062	1035	8	pa	pa	PROPN
gs-4062	1035	9	,	,	PUNCT
gs-4062	1035	10	stolbach	stolbach	NOUN
gs-4062	1035	11	a.	a.	NOUN
gs-4062	1035	12	a	a	DET
gs-4062	1035	13	review	review	NOUN
gs-4062	1035	14	of	of	ADP
gs-4062	1035	15	the	the	DET
gs-4062	1035	16	toxicity	toxicity	NOUN
gs-4062	1035	17	of	of	ADP
gs-4062	1035	18	hiv	hiv	PROPN
gs-4062	1035	19	medications	medication	NOUN
gs-4062	1035	20	.	.	PUNCT
gs-4062	1036	1	j	j	PROPN
gs-4062	1036	2	med	med	PROPN
gs-4062	1036	3	toxicol	toxicol	PROPN
gs-4062	1036	4	.	.	PUNCT
gs-4062	1036	5	2014	2014	NUM
gs-4062	1037	1	mar;10(1):26	mar;10(1):26	PROPN
gs-4062	1037	2	-	-	SYM
gs-4062	1037	3	39	39	NUM
gs-4062	1037	4	.	.	PUNCT
gs-4062	1038	1	georgian	georgian	NOUN
gs-4062	1038	2	scientists/	scientists/	NUM
gs-4062	1038	3	.	.	PUNCT
gs-4062	1039	1	7	7	NUM
gs-4062	1039	2	n	n	PRON
gs-4062	1039	3	3	3	NUM
gs-4062	1039	4	,	,	PUNCT
gs-4062	1039	5	2025	2025	NUM
gs-4062	1039	6	564	564	NUM
gs-4062	1039	7	15	15	NUM
gs-4062	1039	8	.	.	PUNCT
gs-4062	1040	1	hawkins	hawkins	PROPN
gs-4062	1040	2	t.	t.	PROPN
gs-4062	1040	3	understanding	understanding	NOUN
gs-4062	1040	4	and	and	CCONJ
gs-4062	1040	5	managing	manage	VERB
gs-4062	1040	6	the	the	DET
gs-4062	1040	7	adverse	adverse	ADJ
gs-4062	1040	8	effects	effect	NOUN
gs-4062	1040	9	of	of	ADP
gs-4062	1040	10	antiretroviral	antiretroviral	ADJ
gs-4062	1040	11	therapy	therapy	NOUN
gs-4062	1040	12	.	.	PUNCT
gs-4062	1041	1	antiviral	antiviral	ADJ
gs-4062	1041	2	res	re	NOUN
gs-4062	1041	3	.	.	PUNCT
gs-4062	1042	1	2010	2010	NUM
gs-4062	1042	2	jan;85(1):201	jan;85(1):201	PROPN
gs-4062	1042	3	-	-	PUNCT
gs-4062	1042	4	9	9	NUM
gs-4062	1042	5	.	.	NUM
gs-4062	1042	6	16	16	NUM
gs-4062	1042	7	.	.	PUNCT
gs-4062	1042	8	apostolova	apostolova	PROPN
gs-4062	1042	9	n	n	CCONJ
gs-4062	1042	10	,	,	PUNCT
gs-4062	1042	11	funes	fune	VERB
gs-4062	1042	12	ha	ha	INTJ
gs-4062	1042	13	,	,	PUNCT
gs-4062	1042	14	blas	blas	PROPN
gs-4062	1042	15	-	-	PUNCT
gs-4062	1042	16	garcia	garcia	PROPN
gs-4062	1042	17	a	a	PRON
gs-4062	1042	18	,	,	PUNCT
gs-4062	1042	19	galindo	galindo	PROPN
gs-4062	1042	20	mj	mj	PROPN
gs-4062	1042	21	,	,	PUNCT
gs-4062	1042	22	alvarez	alvarez	PROPN
gs-4062	1042	23	a	a	PROPN
gs-4062	1042	24	,	,	PUNCT
gs-4062	1042	25	esplugues	esplugue	NOUN
gs-4062	1042	26	jv	jv	NOUN
gs-4062	1042	27	.	.	PUNCT
gs-4062	1042	28	efavirenz	efavirenz	PROPN
gs-4062	1042	29	and	and	CCONJ
gs-4062	1042	30	the	the	DET
gs-4062	1042	31	cns	cns	NOUN
gs-4062	1042	32	:	:	PUNCT
gs-4062	1042	33	what	what	PRON
gs-4062	1042	34	we	we	PRON
gs-4062	1042	35	already	already	ADV
gs-4062	1042	36	know	know	VERB
gs-4062	1042	37	and	and	CCONJ
gs-4062	1042	38	what	what	PRON
gs-4062	1042	39	we	we	PRON
gs-4062	1042	40	need	need	VERB
gs-4062	1042	41	to	to	PART
gs-4062	1042	42	know	know	VERB
gs-4062	1042	43	.	.	PUNCT
gs-4062	1043	1	j	j	PROPN
gs-4062	1043	2	antimicrob	antimicrob	PROPN
gs-4062	1043	3	chemother	chemother	PROPN
gs-4062	1043	4	.	.	PUNCT
gs-4062	1044	1	2015	2015	NUM
gs-4062	1044	2	dec;70(12):2693	dec;70(12):2693	NOUN
gs-4062	1044	3	-	-	PUNCT
gs-4062	1044	4	708	708	NUM
gs-4062	1044	5	.	.	PUNCT
gs-4062	1044	6	17	17	NUM
gs-4062	1044	7	.	.	PUNCT
gs-4062	1044	8	milpied	milpie	VERB
gs-4062	1044	9	-	-	PUNCT
gs-4062	1044	10	homsi	homsi	NOUN
gs-4062	1044	11	b	b	NUM
gs-4062	1044	12	,	,	PUNCT
gs-4062	1044	13	moran	moran	PROPN
gs-4062	1044	14	mt	mt	PROPN
gs-4062	1044	15	,	,	PUNCT
gs-4062	1044	16	feuillade	feuillade	PROPN
gs-4062	1044	17	de	de	PROPN
gs-4062	1044	18	chauvin	chauvin	PROPN
gs-4062	1044	19	m.	m.	PROPN
gs-4062	1044	20	cutaneous	cutaneous	ADJ
gs-4062	1044	21	adverse	adverse	ADJ
gs-4062	1044	22	effects	effect	NOUN
gs-4062	1044	23	of	of	ADP
gs-4062	1044	24	antiretroviral	antiretroviral	ADJ
gs-4062	1044	25	agents	agent	NOUN
gs-4062	1044	26	.	.	PUNCT
gs-4062	1045	1	part	part	NOUN
gs-4062	1046	1	i	i	PRON
gs-4062	1046	2	:	:	PUNCT
gs-4062	1046	3	nucleoside	nucleoside	ADV
gs-4062	1046	4	reverse	reverse	VERB
gs-4062	1046	5	transcriptase	transcriptase	NOUN
gs-4062	1046	6	inhibitors	inhibitor	NOUN
gs-4062	1046	7	and	and	CCONJ
gs-4062	1046	8	non	non	ADJ
gs-4062	1046	9	-	-	ADJ
gs-4062	1046	10	nucleoside	nucleoside	ADJ
gs-4062	1046	11	reverse	reverse	ADJ
gs-4062	1046	12	transcriptase	transcriptase	NOUN
gs-4062	1046	13	inhibitors	inhibitor	NOUN
gs-4062	1046	14	.	.	PUNCT
gs-4062	1047	1	ann	ann	PROPN
gs-4062	1047	2	dermatol	dermatol	NOUN
gs-4062	1047	3	venereol	venereol	NOUN
gs-4062	1047	4	.	.	PUNCT
gs-4062	1048	1	2010	2010	NUM
gs-4062	1048	2	sep;137(8	sep;137(8	PROPN
gs-4062	1048	3	-	-	PUNCT
gs-4062	1048	4	9):537	9):537	NUM
gs-4062	1048	5	-	-	PUNCT
gs-4062	1048	6	46	46	NUM
gs-4062	1048	7	.	.	PUNCT
gs-4062	1049	1	18	18	NUM
gs-4062	1049	2	.	.	PUNCT
gs-4062	1049	3	carr	carr	PROPN
gs-4062	1049	4	a	a	PROPN
gs-4062	1049	5	,	,	PUNCT
gs-4062	1049	6	cooper	cooper	PROPN
gs-4062	1049	7	da	da	PROPN
gs-4062	1049	8	.	.	PROPN
gs-4062	1049	9	adverse	adverse	ADJ
gs-4062	1049	10	effects	effect	NOUN
gs-4062	1049	11	of	of	ADP
gs-4062	1049	12	antiretroviral	antiretroviral	ADJ
gs-4062	1049	13	therapy	therapy	NOUN
gs-4062	1049	14	.	.	PUNCT
gs-4062	1050	1	lancet	lancet	PROPN
gs-4062	1050	2	.	.	PUNCT
gs-4062	1051	1	2000	2000	NUM
gs-4062	1051	2	oct	oct	NOUN
gs-4062	1051	3	21;356(9239):1423	21;356(9239):1423	NUM
gs-4062	1051	4	-	-	SYM
gs-4062	1051	5	30	30	NUM
gs-4062	1051	6	.	.	PUNCT
gs-4062	1052	1	19	19	NUM
gs-4062	1052	2	.	.	X
gs-4062	1052	3	sax	sax	PROPN
gs-4062	1052	4	pe	pe	PROPN
gs-4062	1052	5	,	,	PUNCT
gs-4062	1052	6	erlandson	erlandson	PROPN
gs-4062	1052	7	km	km	PROPN
gs-4062	1052	8	,	,	PUNCT
gs-4062	1052	9	lake	lake	PROPN
gs-4062	1052	10	je	je	PROPN
gs-4062	1052	11	,	,	PUNCT
gs-4062	1052	12	mccomsey	mccomsey	PROPN
gs-4062	1052	13	ga	ga	PROPN
gs-4062	1052	14	,	,	PUNCT
gs-4062	1052	15	orkin	orkin	PROPN
gs-4062	1052	16	c	c	PROPN
gs-4062	1052	17	,	,	PUNCT
gs-4062	1052	18	esser	esser	NOUN
gs-4062	1052	19	s	s	PART
gs-4062	1052	20	,	,	PUNCT
gs-4062	1052	21	et	et	PROPN
gs-4062	1052	22	al	al	PROPN
gs-4062	1052	23	.	.	PUNCT
gs-4062	1052	24	weight	weight	NOUN
gs-4062	1052	25	gain	gain	NOUN
gs-4062	1052	26	following	follow	VERB
gs-4062	1052	27	initiation	initiation	NOUN
gs-4062	1052	28	of	of	ADP
gs-4062	1052	29	antiretroviral	antiretroviral	ADJ
gs-4062	1052	30	therapy	therapy	NOUN
gs-4062	1052	31	:	:	PUNCT
gs-4062	1052	32	risk	risk	NOUN
gs-4062	1052	33	factors	factor	NOUN
gs-4062	1052	34	in	in	ADP
gs-4062	1052	35	randomized	randomized	ADJ
gs-4062	1052	36	comparative	comparative	ADJ
gs-4062	1052	37	clinical	clinical	ADJ
gs-4062	1052	38	trials	trial	NOUN
gs-4062	1052	39	.	.	PUNCT
gs-4062	1053	1	clin	clin	PROPN
gs-4062	1053	2	infect	infect	PROPN
gs-4062	1053	3	dis	dis	PROPN
gs-4062	1053	4	.	.	PUNCT
gs-4062	1054	1	2020	2020	NUM
gs-4062	1054	2	nov	nov	NOUN
gs-4062	1054	3	5;71(6):1379	5;71(6):1379	NUM
gs-4062	1054	4	-	-	SYM
gs-4062	1054	5	1389	1389	NUM
gs-4062	1054	6	.	.	PUNCT
gs-4062	1055	1	20	20	NUM
gs-4062	1055	2	.	.	PUNCT
gs-4062	1055	3	venter	venter	PROPN
gs-4062	1055	4	wdf	wdf	PROPN
gs-4062	1055	5	,	,	PUNCT
gs-4062	1055	6	moorhouse	moorhouse	NOUN
gs-4062	1055	7	m	m	PROPN
gs-4062	1055	8	,	,	PUNCT
gs-4062	1055	9	sokhela	sokhela	PROPN
gs-4062	1055	10	s	s	PROPN
gs-4062	1055	11	,	,	PUNCT
gs-4062	1055	12	fairlie	fairlie	PROPN
gs-4062	1055	13	l	l	PROPN
gs-4062	1055	14	,	,	PUNCT
gs-4062	1055	15	mashabane	mashabane	ADJ
gs-4062	1055	16	n	n	CCONJ
gs-4062	1055	17	,	,	PUNCT
gs-4062	1055	18	masenya	masenya	PROPN
gs-4062	1055	19	m	m	PROPN
gs-4062	1055	20	,	,	PUNCT
gs-4062	1055	21	et	et	PROPN
gs-4062	1055	22	al	al	PROPN
gs-4062	1055	23	.	.	PUNCT
gs-4062	1056	1	dolutegravir	dolutegravir	NOUN
gs-4062	1056	2	plus	plus	CCONJ
gs-4062	1056	3	two	two	NUM
gs-4062	1056	4	different	different	ADJ
gs-4062	1056	5	prodrugs	prodrug	NOUN
gs-4062	1056	6	of	of	ADP
gs-4062	1056	7	tenofovir	tenofovir	NOUN
gs-4062	1056	8	to	to	PART
gs-4062	1056	9	treat	treat	VERB
gs-4062	1056	10	hiv	hiv	PROPN
gs-4062	1056	11	.	.	PUNCT
gs-4062	1057	1	n	n	PROPN
gs-4062	1057	2	engl	engl	PROPN
gs-4062	1057	3	j	j	PROPN
gs-4062	1057	4	med	med	PROPN
gs-4062	1057	5	.	.	PUNCT
gs-4062	1058	1	2019	2019	NUM
gs-4062	1058	2	aug	aug	PROPN
gs-4062	1058	3	29;381(9):803815	29;381(9):803815	NUM
gs-4062	1058	4	.	.	PUNCT
gs-4062	1058	5	21	21	NUM
gs-4062	1058	6	.	.	PUNCT
gs-4062	1058	7	gallant	gallant	PROPN
gs-4062	1058	8	j	j	PROPN
gs-4062	1058	9	,	,	PUNCT
gs-4062	1058	10	lazzarin	lazzarin	PROPN
gs-4062	1058	11	a	a	NOUN
gs-4062	1058	12	,	,	PUNCT
gs-4062	1058	13	mills	mill	NOUN
gs-4062	1058	14	a	a	PRON
gs-4062	1058	15	,	,	PUNCT
gs-4062	1058	16	orkin	orkin	PROPN
gs-4062	1058	17	c	c	NOUN
gs-4062	1058	18	,	,	PUNCT
gs-4062	1058	19	podzamczer	podzamczer	NOUN
gs-4062	1058	20	d	d	PROPN
gs-4062	1058	21	,	,	PUNCT
gs-4062	1058	22	tebas	tebas	PROPN
gs-4062	1058	23	p	p	X
gs-4062	1058	24	,	,	PUNCT
gs-4062	1058	25	et	et	PROPN
gs-4062	1058	26	al	al	PROPN
gs-4062	1058	27	.	.	PROPN
gs-4062	1059	1	bictegravir	bictegravir	PROPN
gs-4062	1059	2	,	,	PUNCT
gs-4062	1059	3	emtricitabine	emtricitabine	PROPN
gs-4062	1059	4	,	,	PUNCT
gs-4062	1059	5	and	and	CCONJ
gs-4062	1059	6	tenofovir	tenofovir	PROPN
gs-4062	1059	7	alafenamide	alafenamide	PROPN
gs-4062	1059	8	versus	versus	ADP
gs-4062	1059	9	dolutegravir	dolutegravir	PROPN
gs-4062	1059	10	,	,	PUNCT
gs-4062	1059	11	abacavir	abacavir	VERB
gs-4062	1059	12	,	,	PUNCT
gs-4062	1059	13	and	and	CCONJ
gs-4062	1059	14	lamivudine	lamivudine	NOUN
gs-4062	1059	15	for	for	ADP
gs-4062	1059	16	initial	initial	ADJ
gs-4062	1059	17	treatment	treatment	NOUN
gs-4062	1059	18	of	of	ADP
gs-4062	1059	19	hiv-1	hiv-1	ADJ
gs-4062	1059	20	infection	infection	NOUN
gs-4062	1059	21	(	(	PUNCT
gs-4062	1059	22	gs	gs	NOUN
gs-4062	1059	23	-	-	PUNCT
gs-4062	1059	24	us-380	us-380	NOUN
gs-4062	1059	25	-	-	PUNCT
gs-4062	1059	26	1489	1489	NUM
gs-4062	1059	27	):	):	PUNCT
gs-4062	1059	28	a	a	DET
gs-4062	1059	29	double	double	ADJ
gs-4062	1059	30	-	-	PUNCT
gs-4062	1059	31	blind	blind	ADJ
gs-4062	1059	32	,	,	PUNCT
gs-4062	1059	33	multicentre	multicentre	NOUN
gs-4062	1059	34	,	,	PUNCT
gs-4062	1059	35	phase	phase	NOUN
gs-4062	1059	36	3	3	NUM
gs-4062	1059	37	,	,	PUNCT
gs-4062	1059	38	randomised	randomise	VERB
gs-4062	1059	39	controlled	control	VERB
gs-4062	1059	40	non	non	ADJ
gs-4062	1059	41	-	-	ADJ
gs-4062	1059	42	inferiority	inferiority	ADJ
gs-4062	1059	43	trial	trial	NOUN
gs-4062	1059	44	.	.	PUNCT
gs-4062	1060	1	lancet	lancet	NOUN
gs-4062	1060	2	.	.	PUNCT
gs-4062	1061	1	2017	2017	NUM
gs-4062	1061	2	nov	nov	NOUN
gs-4062	1061	3	18;390(10107):2063	18;390(10107):2063	NUM
gs-4062	1061	4	-	-	SYM
gs-4062	1061	5	2072	2072	NUM
gs-4062	1061	6	.	.	PUNCT
gs-4062	1062	1	22	22	NUM
gs-4062	1062	2	.	.	PUNCT
gs-4062	1063	1	orkin	orkin	PROPN
gs-4062	1063	2	c	c	PROPN
gs-4062	1063	3	,	,	PUNCT
gs-4062	1063	4	arasteh	arasteh	PROPN
gs-4062	1063	5	k	k	PROPN
gs-4062	1063	6	,	,	PUNCT
gs-4062	1063	7	górgolas	górgolas	PROPN
gs-4062	1063	8	hernández	hernández	PROPN
gs-4062	1063	9	-	-	PUNCT
gs-4062	1063	10	mora	mora	PROPN
gs-4062	1063	11	m	m	PROPN
gs-4062	1063	12	,	,	PUNCT
gs-4062	1063	13	pokrovsky	pokrovsky	PROPN
gs-4062	1063	14	v	v	NOUN
gs-4062	1063	15	,	,	PUNCT
gs-4062	1063	16	overton	overton	PROPN
gs-4062	1063	17	et	et	PROPN
gs-4062	1063	18	,	,	PUNCT
gs-4062	1063	19	girard	girard	PROPN
gs-4062	1063	20	pm	pm	PROPN
gs-4062	1063	21	,	,	PUNCT
gs-4062	1063	22	et	et	PROPN
gs-4062	1063	23	al	al	PROPN
gs-4062	1063	24	.	.	PUNCT
gs-4062	1064	1	long	long	ADV
gs-4062	1064	2	-	-	PUNCT
gs-4062	1064	3	acting	act	VERB
gs-4062	1064	4	cabotegravir	cabotegravir	NOUN
gs-4062	1064	5	and	and	CCONJ
gs-4062	1064	6	rilpivirine	rilpivirine	VERB
gs-4062	1064	7	after	after	ADP
gs-4062	1064	8	oral	oral	ADJ
gs-4062	1064	9	induction	induction	NOUN
gs-4062	1064	10	for	for	ADP
gs-4062	1064	11	hiv-1	hiv-1	ADJ
gs-4062	1064	12	infection	infection	NOUN
gs-4062	1064	13	.	.	PUNCT
gs-4062	1065	1	n	n	PROPN
gs-4062	1065	2	engl	engl	PROPN
gs-4062	1065	3	j	j	PROPN
gs-4062	1065	4	med	med	PROPN
gs-4062	1065	5	.	.	PUNCT
gs-4062	1066	1	2020	2020	NUM
gs-4062	1066	2	mar	mar	PROPN
gs-4062	1066	3	19;382(12):1124	19;382(12):1124	PROPN
gs-4062	1066	4	-	-	PUNCT
gs-4062	1066	5	1135	1135	NUM
gs-4062	1066	6	.	.	PUNCT
gs-4062	1067	1	23	23	NUM
gs-4062	1067	2	.	.	PUNCT
gs-4062	1068	1	swindells	swindell	NOUN
gs-4062	1068	2	s	s	PART
gs-4062	1068	3	,	,	PUNCT
gs-4062	1068	4	andrade	andrade	PROPN
gs-4062	1068	5	-	-	PUNCT
gs-4062	1068	6	villanueva	villanueva	PROPN
gs-4062	1068	7	jf	jf	PROPN
gs-4062	1068	8	,	,	PUNCT
gs-4062	1068	9	richmond	richmond	PROPN
gs-4062	1068	10	gj	gj	PROPN
gs-4062	1068	11	,	,	PUNCT
gs-4062	1068	12	rizzardini	rizzardini	VERB
gs-4062	1068	13	g	g	NOUN
gs-4062	1068	14	,	,	PUNCT
gs-4062	1068	15	baumgarten	baumgarten	VERB
gs-4062	1068	16	a	a	PRON
gs-4062	1068	17	,	,	PUNCT
gs-4062	1068	18	masiá	masiá	NOUN
gs-4062	1068	19	m	m	PROPN
gs-4062	1068	20	,	,	PUNCT
gs-4062	1068	21	et	et	PROPN
gs-4062	1068	22	al	al	PROPN
gs-4062	1068	23	.	.	PUNCT
gs-4062	1068	24	long	long	ADV
gs-4062	1068	25	-	-	PUNCT
gs-4062	1068	26	acting	act	VERB
gs-4062	1068	27	cabotegravir	cabotegravir	NOUN
gs-4062	1068	28	and	and	CCONJ
gs-4062	1068	29	rilpivirine	rilpivirine	VERB
gs-4062	1068	30	for	for	ADP
gs-4062	1068	31	maintenance	maintenance	NOUN
gs-4062	1068	32	of	of	ADP
gs-4062	1068	33	hiv-1	hiv-1	ADJ
gs-4062	1068	34	suppression	suppression	NOUN
gs-4062	1068	35	.	.	PUNCT
gs-4062	1069	1	n	n	PROPN
gs-4062	1069	2	engl	engl	PROPN
gs-4062	1069	3	j	j	PROPN
gs-4062	1069	4	med	med	PROPN
gs-4062	1069	5	.	.	PUNCT
gs-4062	1070	1	2020	2020	NUM
gs-4062	1070	2	mar	mar	PROPN
gs-4062	1070	3	19;382(12):1112	19;382(12):1112	PROPN
gs-4062	1070	4	-	-	PUNCT
gs-4062	1070	5	1123	1123	NUM
gs-4062	1070	6	.	.	PUNCT
gs-4062	1071	1	24	24	NUM
gs-4062	1071	2	.	.	PUNCT
gs-4062	1071	3	markowitz	markowitz	PROPN
gs-4062	1071	4	m	m	PROPN
gs-4062	1071	5	,	,	PUNCT
gs-4062	1071	6	grossman	grossman	PROPN
gs-4062	1071	7	h	h	PROPN
gs-4062	1071	8	,	,	PUNCT
gs-4062	1071	9	anderson	anderson	PROPN
gs-4062	1071	10	pl	pl	PROPN
gs-4062	1071	11	,	,	PUNCT
gs-4062	1071	12	grant	grant	PROPN
gs-4062	1071	13	r	r	NOUN
gs-4062	1071	14	,	,	PUNCT
gs-4062	1071	15	gandhi	gandhi	PROPN
gs-4062	1071	16	rt	rt	PROPN
gs-4062	1071	17	,	,	PUNCT
gs-4062	1071	18	horowitz	horowitz	PROPN
gs-4062	1071	19	a	a	PROPN
gs-4062	1071	20	,	,	PUNCT
gs-4062	1071	21	et	et	PROPN
gs-4062	1071	22	al	al	PROPN
gs-4062	1071	23	.	.	PUNCT
gs-4062	1071	24	newly	newly	ADV
gs-4062	1071	25	acquired	acquire	VERB
gs-4062	1071	26	infection	infection	NOUN
gs-4062	1071	27	with	with	ADP
gs-4062	1071	28	multi	multi	ADJ
gs-4062	1071	29	-	-	ADJ
gs-4062	1071	30	drug	drug	ADJ
gs-4062	1071	31	resistant	resistant	ADJ
gs-4062	1071	32	hiv-1	hiv-1	PUNCT
gs-4062	1071	33	in	in	ADP
gs-4062	1071	34	a	a	DET
gs-4062	1071	35	patient	patient	ADJ
gs-4062	1071	36	adherent	adherent	NOUN
gs-4062	1071	37	to	to	ADP
gs-4062	1071	38	pre	pre	ADJ
gs-4062	1071	39	-	-	ADJ
gs-4062	1071	40	exposure	exposure	ADJ
gs-4062	1071	41	prophylaxis	prophylaxis	NOUN
gs-4062	1071	42	.	.	PUNCT
gs-4062	1072	1	j	j	PROPN
gs-4062	1072	2	acquir	acquir	PROPN
gs-4062	1072	3	immune	immune	VERB
gs-4062	1072	4	defic	defic	ADJ
gs-4062	1072	5	syndr	syndr	NOUN
gs-4062	1072	6	.	.	PUNCT
gs-4062	1073	1	2017	2017	NUM
gs-4062	1073	2	dec	dec	PROPN
gs-4062	1073	3	1;76(4):e104	1;76(4):e104	PROPN
gs-4062	1073	4	-	-	PUNCT
gs-4062	1073	5	e106	e106	PROPN
gs-4062	1073	6	.	.	PUNCT
gs-4062	1073	7	25	25	NUM
gs-4062	1073	8	.	.	PUNCT
gs-4062	1074	1	saag	saag	PROPN
gs-4062	1074	2	ms	ms	PROPN
gs-4062	1074	3	,	,	PUNCT
gs-4062	1074	4	gandhi	gandhi	PROPN
gs-4062	1074	5	rt	rt	PROPN
gs-4062	1074	6	,	,	PUNCT
gs-4062	1074	7	hoy	hoy	PROPN
gs-4062	1074	8	jf	jf	PROPN
gs-4062	1074	9	,	,	PUNCT
gs-4062	1074	10	landovitz	landovitz	PROPN
gs-4062	1074	11	rj	rj	PROPN
gs-4062	1074	12	,	,	PUNCT
gs-4062	1074	13	thompson	thompson	PROPN
gs-4062	1074	14	ma	ma	PROPN
gs-4062	1074	15	,	,	PUNCT
gs-4062	1074	16	sax	sax	PROPN
gs-4062	1074	17	pe	pe	PROPN
gs-4062	1074	18	,	,	PUNCT
gs-4062	1074	19	et	et	PROPN
gs-4062	1074	20	al	al	PROPN
gs-4062	1074	21	.	.	PROPN
gs-4062	1075	1	antiretroviral	antiretroviral	ADJ
gs-4062	1075	2	drugs	drug	NOUN
gs-4062	1075	3	for	for	ADP
gs-4062	1075	4	treatment	treatment	NOUN
gs-4062	1075	5	and	and	CCONJ
gs-4062	1075	6	prevention	prevention	NOUN
gs-4062	1075	7	of	of	ADP
gs-4062	1075	8	hiv	hiv	PROPN
gs-4062	1075	9	infection	infection	NOUN
gs-4062	1075	10	in	in	ADP
gs-4062	1075	11	adults	adult	NOUN
gs-4062	1075	12	:	:	PUNCT
gs-4062	1075	13	2020	2020	NUM
gs-4062	1075	14	recommendations	recommendation	NOUN
gs-4062	1075	15	of	of	ADP
gs-4062	1075	16	the	the	DET
gs-4062	1075	17	international	international	ADJ
gs-4062	1075	18	antiviral	antiviral	ADJ
gs-4062	1075	19	society	society	PROPN
gs-4062	1075	20	-	-	PUNCT
gs-4062	1075	21	usa	usa	PROPN
gs-4062	1075	22	panel	panel	NOUN
gs-4062	1075	23	.	.	PUNCT
gs-4062	1076	1	jama	jama	PROPN
gs-4062	1076	2	.	.	PUNCT
gs-4062	1077	1	2020	2020	NUM
gs-4062	1077	2	oct	oct	PROPN
gs-4062	1077	3	27;324(16):1651	27;324(16):1651	NUM
gs-4062	1077	4	-	-	SYM
gs-4062	1077	5	1669	1669	NUM
gs-4062	1077	6	.	.	PUNCT
gs-4062	1078	1	26	26	NUM
gs-4062	1078	2	.	.	PUNCT
gs-4062	1079	1	rizzardini	rizzardini	PROPN
gs-4062	1079	2	g	g	PROPN
gs-4062	1079	3	,	,	PUNCT
gs-4062	1079	4	overton	overton	PROPN
gs-4062	1079	5	et	et	PROPN
gs-4062	1079	6	,	,	PUNCT
gs-4062	1079	7	orkin	orkin	PROPN
gs-4062	1079	8	c	c	PROPN
gs-4062	1079	9	,	,	PUNCT
gs-4062	1079	10	swindells	swindell	NOUN
gs-4062	1079	11	s	s	PROPN
gs-4062	1079	12	,	,	PUNCT
gs-4062	1079	13	arasteh	arasteh	PROPN
gs-4062	1079	14	k	k	PROPN
gs-4062	1079	15	,	,	PUNCT
gs-4062	1079	16	górgolas	górgolas	PROPN
gs-4062	1079	17	hernández	hernández	PROPN
gs-4062	1079	18	-	-	PUNCT
gs-4062	1079	19	mora	mora	PROPN
gs-4062	1079	20	m	m	PROPN
gs-4062	1079	21	,	,	PUNCT
gs-4062	1079	22	et	et	PROPN
gs-4062	1079	23	al	al	PROPN
gs-4062	1079	24	.	.	PUNCT
gs-4062	1079	25	long	long	ADV
gs-4062	1079	26	-	-	PUNCT
gs-4062	1079	27	acting	act	VERB
gs-4062	1079	28	injectable	injectable	NOUN
gs-4062	1079	29	cabotegravir	cabotegravir	VERB
gs-4062	1079	30	+	+	CCONJ
gs-4062	1079	31	rilpivirine	rilpivirine	VERB
gs-4062	1079	32	for	for	ADP
gs-4062	1079	33	hiv	hiv	PROPN
gs-4062	1079	34	maintenance	maintenance	NOUN
gs-4062	1079	35	therapy	therapy	NOUN
gs-4062	1079	36	:	:	PUNCT
gs-4062	1079	37	week	week	NOUN
gs-4062	1079	38	48	48	NUM
gs-4062	1079	39	pooled	pool	VERB
gs-4062	1079	40	analysis	analysis	NOUN
gs-4062	1079	41	of	of	ADP
gs-4062	1079	42	phase	phase	NOUN
gs-4062	1079	43	3	3	NUM
gs-4062	1079	44	atlas	atlas	ADJ
gs-4062	1079	45	and	and	CCONJ
gs-4062	1079	46	flair	flair	NOUN
gs-4062	1079	47	trials	trial	NOUN
gs-4062	1079	48	.	.	PUNCT
gs-4062	1080	1	j	j	PROPN
gs-4062	1080	2	acquir	acquir	PROPN
gs-4062	1080	3	immune	immune	VERB
gs-4062	1080	4	defic	defic	ADJ
gs-4062	1080	5	syndr	syndr	NOUN
gs-4062	1080	6	.	.	PUNCT
gs-4062	1081	1	2020	2020	NUM
gs-4062	1081	2	dec	dec	PROPN
gs-4062	1081	3	15;85(5):648	15;85(5):648	PROPN
gs-4062	1081	4	-	-	SYM
gs-4062	1081	5	660	660	NUM
gs-4062	1081	6	.	.	NOUN
gs-4062	1081	7	27	27	NUM
gs-4062	1081	8	.	.	PUNCT
gs-4062	1081	9	deeks	deek	VERB
gs-4062	1081	10	ed	ed	PROPN
gs-4062	1081	11	.	.	PUNCT
gs-4062	1081	12	ibalizumab	ibalizumab	PROPN
gs-4062	1081	13	:	:	PUNCT
gs-4062	1081	14	a	a	DET
gs-4062	1081	15	review	review	NOUN
gs-4062	1081	16	in	in	ADP
gs-4062	1081	17	multidrug	multidrug	NOUN
gs-4062	1081	18	-	-	PUNCT
gs-4062	1081	19	resistant	resistant	ADJ
gs-4062	1081	20	hiv-1	hiv-1	ADJ
gs-4062	1081	21	infection	infection	NOUN
gs-4062	1081	22	.	.	PUNCT
gs-4062	1082	1	drugs	drug	NOUN
gs-4062	1082	2	.	.	PUNCT
gs-4062	1083	1	2020	2020	NUM
gs-4062	1083	2	feb;80(2):189	feb;80(2):189	SYM
gs-4062	1083	3	-	-	PUNCT
gs-4062	1083	4	196	196	NUM
gs-4062	1083	5	.	.	PUNCT
gs-4062	1084	1	28	28	NUM
gs-4062	1084	2	.	.	PUNCT
gs-4062	1085	1	namasopo	namasopo	PROPN
gs-4062	1085	2	s	s	PROPN
gs-4062	1085	3	,	,	PUNCT
gs-4062	1085	4	krentz	krentz	PROPN
gs-4062	1085	5	hb	hb	PROPN
gs-4062	1085	6	,	,	PUNCT
gs-4062	1085	7	gill	gill	PROPN
gs-4062	1085	8	mj	mj	PROPN
gs-4062	1085	9	.	.	PROPN
gs-4062	1085	10	neuropsychiatric	neuropsychiatric	ADJ
gs-4062	1085	11	adverse	adverse	ADJ
gs-4062	1085	12	effects	effect	NOUN
gs-4062	1085	13	of	of	ADP
gs-4062	1085	14	dolutegravir	dolutegravir	NOUN
gs-4062	1085	15	:	:	PUNCT
gs-4062	1085	16	a	a	DET
gs-4062	1085	17	emerging	emerge	VERB
gs-4062	1085	18	issue	issue	NOUN
gs-4062	1085	19	in	in	ADP
gs-4062	1085	20	a	a	DET
gs-4062	1085	21	successful	successful	ADJ
gs-4062	1085	22	antiretroviral	antiretroviral	ADJ
gs-4062	1085	23	regimen	regiman	NOUN
gs-4062	1085	24	.	.	PUNCT
gs-4062	1086	1	aids	aids	PROPN
gs-4062	1086	2	.	.	PUNCT
gs-4062	1087	1	2018	2018	NUM
gs-4062	1087	2	jul	jul	NOUN
gs-4062	1087	3	17;32(11):1491	17;32(11):1491	NUM
gs-4062	1087	4	-	-	SYM
gs-4062	1087	5	1493	1493	NUM
gs-4062	1087	6	.	.	PUNCT
gs-4062	1088	1	29	29	NUM
gs-4062	1088	2	.	.	PUNCT
gs-4062	1089	1	hoffmann	hoffmann	PROPN
gs-4062	1089	2	c	c	PROPN
gs-4062	1089	3	,	,	PUNCT
gs-4062	1089	4	welz	welz	PROPN
gs-4062	1089	5	t	t	PROPN
gs-4062	1089	6	,	,	PUNCT
gs-4062	1089	7	sabranski	sabranski	PROPN
gs-4062	1089	8	m	m	PROPN
gs-4062	1089	9	,	,	PUNCT
gs-4062	1089	10	kolb	kolb	PROPN
gs-4062	1089	11	m	m	PROPN
gs-4062	1089	12	,	,	PUNCT
gs-4062	1089	13	wolf	wolf	PROPN
gs-4062	1089	14	e	e	NOUN
gs-4062	1089	15	,	,	PUNCT
gs-4062	1089	16	stellbrink	stellbrink	VERB
gs-4062	1089	17	hj	hj	PROPN
gs-4062	1089	18	,	,	PUNCT
gs-4062	1089	19	et	et	PROPN
gs-4062	1089	20	al	al	PROPN
gs-4062	1089	21	.	.	PUNCT
gs-4062	1090	1	higher	high	ADJ
gs-4062	1090	2	rates	rate	NOUN
gs-4062	1090	3	of	of	ADP
gs-4062	1090	4	neuropsychiatric	neuropsychiatric	ADJ
gs-4062	1090	5	adverse	adverse	ADJ
gs-4062	1090	6	events	event	NOUN
gs-4062	1090	7	leading	lead	VERB
gs-4062	1090	8	to	to	ADP
gs-4062	1090	9	dolutegravir	dolutegravir	NOUN
gs-4062	1090	10	discontinuation	discontinuation	NOUN
gs-4062	1090	11	in	in	ADP
gs-4062	1090	12	women	woman	NOUN
gs-4062	1090	13	and	and	CCONJ
gs-4062	1090	14	older	old	ADJ
gs-4062	1090	15	patients	patient	NOUN
gs-4062	1090	16	.	.	PUNCT
gs-4062	1091	1	hiv	hiv	PROPN
gs-4062	1091	2	med	med	PROPN
gs-4062	1091	3	.	.	PROPN
gs-4062	1091	4	2017	2017	NUM
gs-4062	1091	5	jan;18(1):56	jan;18(1):56	PROPN
gs-4062	1091	6	-	-	NOUN
gs-4062	1091	7	63	63	NUM
gs-4062	1091	8	.	.	PUNCT
gs-4062	1092	1	georgian	georgian	NOUN
gs-4062	1092	2	scientists/	scientists/	NUM
gs-4062	1092	3	.	.	PUNCT
gs-4062	1093	1	7	7	NUM
gs-4062	1093	2	n	n	PRON
gs-4062	1093	3	3	3	NUM
gs-4062	1093	4	,	,	PUNCT
gs-4062	1093	5	2025	2025	NUM
gs-4062	1093	6	565	565	NUM
gs-4062	1093	7	30	30	NUM
gs-4062	1093	8	.	.	PUNCT
gs-4062	1094	1	lepik	lepik	PROPN
gs-4062	1094	2	kj	kj	PROPN
gs-4062	1094	3	,	,	PUNCT
gs-4062	1094	4	yip	yip	PROPN
gs-4062	1094	5	b	b	PROPN
gs-4062	1094	6	,	,	PUNCT
gs-4062	1094	7	ulloa	ulloa	PROPN
gs-4062	1094	8	ac	ac	PROPN
gs-4062	1094	9	,	,	PUNCT
gs-4062	1094	10	wang	wang	PROPN
gs-4062	1094	11	l	l	PROPN
gs-4062	1094	12	,	,	PUNCT
gs-4062	1094	13	toy	toy	PROPN
gs-4062	1094	14	j	j	PROPN
gs-4062	1094	15	,	,	PUNCT
gs-4062	1094	16	akagi	akagi	PROPN
gs-4062	1094	17	l	l	PROPN
gs-4062	1094	18	,	,	PUNCT
gs-4062	1094	19	et	et	PROPN
gs-4062	1094	20	al	al	PROPN
gs-4062	1094	21	.	.	PROPN
gs-4062	1095	1	adverse	adverse	ADJ
gs-4062	1095	2	drug	drug	NOUN
gs-4062	1095	3	reactions	reaction	NOUN
gs-4062	1095	4	to	to	PART
gs-4062	1095	5	integrase	integrase	VERB
gs-4062	1095	6	strand	strand	NOUN
gs-4062	1095	7	transfer	transfer	NOUN
gs-4062	1095	8	inhibitors	inhibitor	NOUN
gs-4062	1095	9	.	.	PUNCT
gs-4062	1096	1	aids	aids	PROPN
gs-4062	1096	2	.	.	PUNCT
gs-4062	1097	1	2018	2018	NUM
gs-4062	1097	2	apr	apr	NOUN
gs-4062	1097	3	24;32(7):903	24;32(7):903	NUM
gs-4062	1097	4	-	-	SYM
gs-4062	1097	5	912	912	NUM
gs-4062	1097	6	.	.	PUNCT
gs-4062	1098	1	31	31	NUM
gs-4062	1098	2	.	.	PUNCT
gs-4062	1099	1	elzi	elzi	PROPN
gs-4062	1099	2	l	l	PROPN
gs-4062	1099	3	,	,	PUNCT
gs-4062	1099	4	erb	erb	PROPN
gs-4062	1099	5	s	s	PROPN
gs-4062	1099	6	,	,	PUNCT
gs-4062	1099	7	furrer	furrer	NOUN
gs-4062	1099	8	h	h	NOUN
gs-4062	1099	9	,	,	PUNCT
gs-4062	1099	10	cavassini	cavassini	PROPN
gs-4062	1099	11	m	m	PROPN
gs-4062	1099	12	,	,	PUNCT
gs-4062	1099	13	calmy	calmy	ADV
gs-4062	1099	14	a	a	PRON
gs-4062	1099	15	,	,	PUNCT
gs-4062	1099	16	vernazza	vernazza	ADJ
gs-4062	1099	17	p	p	NOUN
gs-4062	1099	18	,	,	PUNCT
gs-4062	1099	19	et	et	PROPN
gs-4062	1099	20	al	al	PROPN
gs-4062	1099	21	.	.	PROPN
gs-4062	1100	1	adverse	adverse	ADJ
gs-4062	1100	2	events	event	NOUN
gs-4062	1100	3	of	of	ADP
gs-4062	1100	4	raltegravir	raltegravir	NOUN
gs-4062	1100	5	and	and	CCONJ
gs-4062	1100	6	dolutegravir	dolutegravir	NOUN
gs-4062	1100	7	.	.	PUNCT
gs-4062	1101	1	aids	aids	PROPN
gs-4062	1101	2	.	.	PUNCT
gs-4062	1102	1	2017	2017	NUM
gs-4062	1102	2	nov	nov	NOUN
gs-4062	1102	3	28;31(18):2523	28;31(18):2523	NUM
gs-4062	1102	4	-	-	SYM
gs-4062	1102	5	2528	2528	NUM
gs-4062	1102	6	.	.	PUNCT
gs-4062	1103	1	32	32	NUM
gs-4062	1103	2	.	.	PUNCT
gs-4062	1104	1	zash	zash	NOUN
gs-4062	1104	2	r	r	NOUN
gs-4062	1104	3	,	,	PUNCT
gs-4062	1104	4	makhema	makhema	PROPN
gs-4062	1104	5	j	j	PROPN
gs-4062	1104	6	,	,	PUNCT
gs-4062	1104	7	shapiro	shapiro	PROPN
gs-4062	1104	8	rl	rl	PROPN
gs-4062	1104	9	.	.	PROPN
gs-4062	1104	10	neural	neural	ADJ
gs-4062	1104	11	-	-	PUNCT
gs-4062	1104	12	tube	tube	NOUN
gs-4062	1104	13	defects	defect	NOUN
gs-4062	1104	14	with	with	ADP
gs-4062	1104	15	dolutegravir	dolutegravir	NOUN
gs-4062	1104	16	treatment	treatment	NOUN
gs-4062	1104	17	from	from	ADP
gs-4062	1104	18	the	the	DET
gs-4062	1104	19	time	time	NOUN
gs-4062	1104	20	of	of	ADP
gs-4062	1104	21	conception	conception	NOUN
gs-4062	1104	22	.	.	PUNCT
gs-4062	1105	1	n	n	CCONJ
gs-4062	1105	2	engl	engl	PROPN
gs-4062	1105	3	j	j	PROPN
gs-4062	1105	4	med	med	PROPN
gs-4062	1105	5	.	.	PUNCT
gs-4062	1106	1	2018	2018	NUM
gs-4062	1106	2	aug	aug	PROPN
gs-4062	1106	3	23;379(10):979	23;379(10):979	NUM
gs-4062	1106	4	-	-	SYM
gs-4062	1106	5	981	981	NUM
gs-4062	1106	6	.	.	PUNCT
gs-4062	1106	7	33	33	NUM
gs-4062	1106	8	.	.	PUNCT
gs-4062	1107	1	raizes	raize	NOUN
gs-4062	1107	2	e	e	PROPN
gs-4062	1107	3	,	,	PUNCT
gs-4062	1107	4	hsu	hsu	PROPN
gs-4062	1107	5	h	h	PROPN
gs-4062	1107	6	,	,	PUNCT
gs-4062	1107	7	birx	birx	X
gs-4062	1107	8	d	d	X
gs-4062	1107	9	,	,	PUNCT
gs-4062	1107	10	el	el	PROPN
gs-4062	1107	11	-	-	PROPN
gs-4062	1107	12	sadr	sadr	PROPN
gs-4062	1107	13	w	w	PROPN
gs-4062	1107	14	,	,	PUNCT
gs-4062	1107	15	gisslén	gisslén	PROPN
gs-4062	1107	16	m	m	PROPN
gs-4062	1107	17	,	,	PUNCT
gs-4062	1107	18	marovich	marovich	PROPN
gs-4062	1107	19	m	m	PROPN
gs-4062	1107	20	,	,	PUNCT
gs-4062	1107	21	et	et	PROPN
gs-4062	1107	22	al	al	PROPN
gs-4062	1107	23	.	.	PUNCT
gs-4062	1108	1	dolutegravir	dolutegravir	NOUN
gs-4062	1108	2	and	and	CCONJ
gs-4062	1108	3	neural	neural	ADJ
gs-4062	1108	4	tube	tube	NOUN
gs-4062	1108	5	defects	defect	NOUN
gs-4062	1108	6	:	:	PUNCT
gs-4062	1108	7	a	a	DET
gs-4062	1108	8	updated	update	VERB
gs-4062	1108	9	review	review	NOUN
gs-4062	1108	10	of	of	ADP
gs-4062	1108	11	the	the	DET
gs-4062	1108	12	evidence	evidence	NOUN
gs-4062	1108	13	.	.	PUNCT
gs-4062	1109	1	pharmacoepidemiol	pharmacoepidemiol	NOUN
gs-4062	1109	2	drug	drug	PROPN
gs-4062	1109	3	saf	saf	PROPN
gs-4062	1109	4	.	.	PROPN
gs-4062	1109	5	2020	2020	NUM
gs-4062	1109	6	dec;29(12):1681	dec;29(12):1681	PROPN
gs-4062	1109	7	-	-	X
gs-4062	1109	8	1685	1685	NUM
gs-4062	1109	9	.	.	PUNCT
gs-4062	1110	1	34	34	NUM
gs-4062	1110	2	.	.	PUNCT
gs-4062	1111	1	molina	molina	PROPN
gs-4062	1111	2	jm	jm	PROPN
gs-4062	1111	3	,	,	PUNCT
gs-4062	1111	4	squires	squire	NOUN
gs-4062	1111	5	k	k	PROPN
gs-4062	1111	6	,	,	PUNCT
gs-4062	1111	7	sax	sax	PROPN
gs-4062	1111	8	pe	pe	PROPN
gs-4062	1111	9	,	,	PUNCT
gs-4062	1111	10	cahn	cahn	NOUN
gs-4062	1111	11	p	p	X
gs-4062	1111	12	,	,	PUNCT
gs-4062	1111	13	lombaard	lombaard	PROPN
gs-4062	1111	14	j	j	PROPN
gs-4062	1111	15	,	,	PUNCT
gs-4062	1111	16	dejesus	dejesus	PROPN
gs-4062	1111	17	e	e	PROPN
gs-4062	1111	18	,	,	PUNCT
gs-4062	1111	19	et	et	PROPN
gs-4062	1111	20	al	al	PROPN
gs-4062	1111	21	.	.	PROPN
gs-4062	1111	22	doravirine	doravirine	PROPN
gs-4062	1111	23	versus	versus	ADP
gs-4062	1111	24	ritonavirboosted	ritonavirbooste	VERB
gs-4062	1111	25	darunavir	darunavir	PROPN
gs-4062	1111	26	in	in	ADP
gs-4062	1111	27	antiretroviral	antiretroviral	ADJ
gs-4062	1111	28	-	-	PUNCT
gs-4062	1111	29	naive	naive	ADJ
gs-4062	1111	30	adults	adult	NOUN
gs-4062	1111	31	with	with	ADP
gs-4062	1111	32	hiv-1	hiv-1	PUNCT
gs-4062	1111	33	(	(	PUNCT
gs-4062	1111	34	drive	drive	NOUN
gs-4062	1111	35	-	-	PUNCT
gs-4062	1111	36	forward	forward	NOUN
gs-4062	1111	37	):	):	PUNCT
gs-4062	1111	38	96	96	NUM
gs-4062	1111	39	-	-	PUNCT
gs-4062	1111	40	week	week	NOUN
gs-4062	1111	41	results	result	NOUN
gs-4062	1111	42	of	of	ADP
gs-4062	1111	43	a	a	DET
gs-4062	1111	44	randomised	randomised	ADJ
gs-4062	1111	45	,	,	PUNCT
gs-4062	1111	46	double	double	ADJ
gs-4062	1111	47	-	-	PUNCT
gs-4062	1111	48	blind	blind	ADJ
gs-4062	1111	49	,	,	PUNCT
gs-4062	1111	50	non	non	ADJ
gs-4062	1111	51	-	-	NOUN
gs-4062	1111	52	inferiority	inferiority	ADJ
gs-4062	1111	53	,	,	PUNCT
gs-4062	1111	54	phase	phase	NOUN
gs-4062	1111	55	3	3	NUM
gs-4062	1111	56	trial	trial	NOUN
gs-4062	1111	57	.	.	PUNCT
gs-4062	1112	1	lancet	lancet	PROPN
gs-4062	1112	2	hiv	hiv	PROPN
gs-4062	1112	3	.	.	PUNCT
gs-4062	1113	1	2020	2020	NUM
gs-4062	1113	2	jan;7(1):e16	jan;7(1):e16	PROPN
gs-4062	1113	3	-	-	PUNCT
gs-4062	1113	4	e26	e26	PROPN
gs-4062	1113	5	.	.	PUNCT
gs-4062	1114	1	35	35	NUM
gs-4062	1114	2	.	.	PUNCT
gs-4062	1115	1	gatell	gatell	PROPN
gs-4062	1115	2	jm	jm	PROPN
gs-4062	1115	3	,	,	PUNCT
gs-4062	1115	4	assoumou	assoumou	NOUN
gs-4062	1115	5	l	l	PROPN
gs-4062	1115	6	,	,	PUNCT
gs-4062	1115	7	moyle	moyle	PROPN
gs-4062	1115	8	g	g	PROPN
gs-4062	1115	9	,	,	PUNCT
gs-4062	1115	10	waters	water	VERB
gs-4062	1115	11	l	l	PROPN
gs-4062	1115	12	,	,	PUNCT
gs-4062	1115	13	johnson	johnson	PROPN
gs-4062	1115	14	m	m	PROPN
gs-4062	1115	15	,	,	PUNCT
gs-4062	1115	16	domingo	domingo	PROPN
gs-4062	1116	1	p	p	X
gs-4062	1116	2	,	,	PUNCT
gs-4062	1116	3	et	et	PROPN
gs-4062	1116	4	al	al	PROPN
gs-4062	1116	5	.	.	PUNCT
gs-4062	1117	1	switching	switch	VERB
gs-4062	1117	2	from	from	ADP
gs-4062	1117	3	a	a	DET
gs-4062	1117	4	ritonavir	ritonavir	PROPN
gs-4062	1117	5	-	-	PUNCT
gs-4062	1117	6	boosted	boost	VERB
gs-4062	1117	7	protease	protease	NOUN
gs-4062	1117	8	inhibitor	inhibitor	NOUN
gs-4062	1117	9	to	to	ADP
gs-4062	1117	10	a	a	DET
gs-4062	1117	11	dolutegravir	dolutegravir	NOUN
gs-4062	1117	12	-	-	PUNCT
gs-4062	1117	13	based	base	VERB
gs-4062	1117	14	regimen	regiman	NOUN
gs-4062	1117	15	for	for	ADP
gs-4062	1117	16	maintenance	maintenance	NOUN
gs-4062	1117	17	of	of	ADP
gs-4062	1117	18	hiv-1	hiv-1	PUNCT
gs-4062	1117	19	viral	viral	ADJ
gs-4062	1117	20	suppression	suppression	NOUN
gs-4062	1117	21	in	in	ADP
gs-4062	1117	22	patients	patient	NOUN
gs-4062	1117	23	with	with	ADP
gs-4062	1117	24	high	high	ADJ
gs-4062	1117	25	cardiovascular	cardiovascular	ADJ
gs-4062	1117	26	risk	risk	NOUN
gs-4062	1117	27	:	:	PUNCT
gs-4062	1117	28	48	48	NUM
gs-4062	1117	29	-	-	PUNCT
gs-4062	1117	30	week	week	NOUN
gs-4062	1117	31	results	result	NOUN
gs-4062	1117	32	of	of	ADP
gs-4062	1117	33	the	the	DET
gs-4062	1117	34	neat022	neat022	PROPN
gs-4062	1117	35	study	study	NOUN
gs-4062	1117	36	.	.	PUNCT
gs-4062	1118	1	clin	clin	PROPN
gs-4062	1118	2	infect	infect	PROPN
gs-4062	1118	3	dis	dis	PROPN
gs-4062	1118	4	.	.	PUNCT
gs-4062	1119	1	2020	2020	NUM
gs-4062	1119	2	jul	jul	PROPN
gs-4062	1119	3	11;71(2):353	11;71(2):353	PROPN
gs-4062	1119	4	-	-	SYM
gs-4062	1119	5	360	360	NUM
gs-4062	1119	6	.	.	PUNCT
gs-4062	1120	1	36	36	NUM
gs-4062	1120	2	.	.	PUNCT
gs-4062	1121	1	mills	mill	NOUN
gs-4062	1121	2	a	a	PRON
gs-4062	1121	3	,	,	PUNCT
gs-4062	1121	4	crofoot	crofoot	NOUN
gs-4062	1121	5	g	g	PROPN
gs-4062	1121	6	jr	jr	PROPN
gs-4062	1121	7	,	,	PUNCT
gs-4062	1121	8	mcdonald	mcdonald	PROPN
gs-4062	1121	9	c	c	PROPN
gs-4062	1121	10	,	,	PUNCT
gs-4062	1121	11	shalit	shalit	NOUN
gs-4062	1121	12	p	p	X
gs-4062	1121	13	,	,	PUNCT
gs-4062	1121	14	flamm	flamm	PROPN
gs-4062	1121	15	ja	ja	PROPN
gs-4062	1121	16	,	,	PUNCT
gs-4062	1121	17	gathe	gathe	PROPN
gs-4062	1121	18	j	j	PROPN
gs-4062	1121	19	,	,	PUNCT
gs-4062	1121	20	et	et	PROPN
gs-4062	1121	21	al	al	PROPN
gs-4062	1121	22	.	.	PROPN
gs-4062	1122	1	tenofovir	tenofovir	PROPN
gs-4062	1122	2	alafenamide	alafenamide	PROPN
gs-4062	1122	3	versus	versus	ADP
gs-4062	1122	4	tenofovir	tenofovir	PROPN
gs-4062	1122	5	disoproxil	disoproxil	VERB
gs-4062	1122	6	fumarate	fumarate	NOUN
gs-4062	1122	7	in	in	ADP
gs-4062	1122	8	the	the	DET
gs-4062	1122	9	first	first	ADJ
gs-4062	1122	10	protease	protease	NOUN
gs-4062	1122	11	inhibitor	inhibitor	NOUN
gs-4062	1122	12	-	-	PUNCT
gs-4062	1122	13	based	base	VERB
gs-4062	1122	14	single	single	ADJ
gs-4062	1122	15	-	-	PUNCT
gs-4062	1122	16	tablet	tablet	NOUN
gs-4062	1122	17	regimen	regiman	NOUN
gs-4062	1122	18	for	for	ADP
gs-4062	1122	19	initial	initial	ADJ
gs-4062	1122	20	hiv-1	hiv-1	X
gs-4062	1122	21	therapy	therapy	NOUN
gs-4062	1122	22	:	:	PUNCT
gs-4062	1122	23	a	a	DET
gs-4062	1122	24	randomized	randomized	ADJ
gs-4062	1122	25	phase	phase	NOUN
gs-4062	1122	26	2	2	NUM
gs-4062	1122	27	study	study	NOUN
gs-4062	1122	28	.	.	PUNCT
gs-4062	1123	1	j	j	PROPN
gs-4062	1123	2	acquir	acquir	PROPN
gs-4062	1123	3	immune	immune	VERB
gs-4062	1123	4	defic	defic	ADJ
gs-4062	1123	5	syndr	syndr	NOUN
gs-4062	1123	6	.	.	PUNCT
gs-4062	1124	1	2015	2015	NUM
gs-4062	1124	2	may	may	AUX
gs-4062	1124	3	1;69(4):439	1;69(4):439	NUM
gs-4062	1124	4	-	-	SYM
gs-4062	1124	5	45	45	NUM
gs-4062	1124	6	.	.	PUNCT
gs-4062	1125	1	37	37	NUM
gs-4062	1125	2	.	.	PUNCT
gs-4062	1126	1	gallant	gallant	PROPN
gs-4062	1126	2	je	je	PROPN
gs-4062	1126	3	,	,	PUNCT
gs-4062	1126	4	daar	daar	PROPN
gs-4062	1126	5	es	es	PROPN
gs-4062	1126	6	,	,	PUNCT
gs-4062	1126	7	raffi	raffi	PROPN
gs-4062	1126	8	f	f	PROPN
gs-4062	1126	9	,	,	PUNCT
gs-4062	1126	10	brinson	brinson	PROPN
gs-4062	1126	11	c	c	PROPN
gs-4062	1126	12	,	,	PUNCT
gs-4062	1126	13	ruane	ruane	NOUN
gs-4062	1126	14	p	p	NOUN
gs-4062	1126	15	,	,	PUNCT
gs-4062	1126	16	dejesus	dejesus	PROPN
gs-4062	1126	17	e	e	PROPN
gs-4062	1126	18	,	,	PUNCT
gs-4062	1126	19	et	et	PROPN
gs-4062	1126	20	al	al	PROPN
gs-4062	1126	21	.	.	PROPN
gs-4062	1126	22	efficacy	efficacy	NOUN
gs-4062	1126	23	and	and	CCONJ
gs-4062	1126	24	safety	safety	NOUN
gs-4062	1126	25	of	of	ADP
gs-4062	1126	26	tenofovir	tenofovir	PROPN
gs-4062	1126	27	alafenamide	alafenamide	PROPN
gs-4062	1126	28	versus	versus	ADP
gs-4062	1126	29	tenofovir	tenofovir	PROPN
gs-4062	1126	30	disoproxil	disoproxil	VERB
gs-4062	1126	31	fumarate	fumarate	NOUN
gs-4062	1126	32	given	give	VERB
gs-4062	1126	33	as	as	ADP
gs-4062	1126	34	fixed	fix	VERB
gs-4062	1126	35	-	-	PUNCT
gs-4062	1126	36	dose	dose	NOUN
gs-4062	1126	37	combinations	combination	NOUN
gs-4062	1126	38	containing	contain	VERB
gs-4062	1126	39	emtricitabine	emtricitabine	NOUN
gs-4062	1126	40	as	as	ADP
gs-4062	1126	41	backbones	backbone	NOUN
gs-4062	1126	42	for	for	ADP
gs-4062	1126	43	treatment	treatment	NOUN
gs-4062	1126	44	of	of	ADP
gs-4062	1126	45	hiv-1	hiv-1	ADJ
gs-4062	1126	46	infection	infection	NOUN
gs-4062	1126	47	:	:	PUNCT
gs-4062	1126	48	a	a	DET
gs-4062	1126	49	randomised	randomised	ADJ
gs-4062	1126	50	,	,	PUNCT
gs-4062	1126	51	double	double	ADJ
gs-4062	1126	52	-	-	PUNCT
gs-4062	1126	53	blind	blind	ADJ
gs-4062	1126	54	,	,	PUNCT
gs-4062	1126	55	active	active	ADJ
gs-4062	1126	56	-	-	PUNCT
gs-4062	1126	57	controlled	control	VERB
gs-4062	1126	58	phase	phase	NOUN
gs-4062	1126	59	3	3	NUM
gs-4062	1126	60	trial	trial	NOUN
gs-4062	1126	61	.	.	PUNCT
gs-4062	1127	1	lancet	lancet	PROPN
gs-4062	1127	2	infect	infect	PROPN
gs-4062	1127	3	dis	dis	PROPN
gs-4062	1127	4	.	.	PUNCT
gs-4062	1128	1	2016	2016	NUM
gs-4062	1128	2	jan;16(1):43	jan;16(1):43	PROPN
gs-4062	1128	3	-	-	PUNCT
gs-4062	1128	4	52	52	NUM
gs-4062	1128	5	.	.	PUNCT
gs-4062	1128	6	38	38	NUM
gs-4062	1128	7	.	.	PUNCT
gs-4062	1129	1	nelson	nelson	PROPN
gs-4062	1129	2	mr	mr	PROPN
gs-4062	1129	3	,	,	PUNCT
gs-4062	1129	4	katlama	katlama	PROPN
gs-4062	1129	5	c	c	PROPN
gs-4062	1129	6	,	,	PUNCT
gs-4062	1129	7	montaner	montaner	PROPN
gs-4062	1129	8	js	js	PROPN
gs-4062	1129	9	,	,	PUNCT
gs-4062	1129	10	cooper	cooper	PROPN
gs-4062	1129	11	da	da	PROPN
gs-4062	1129	12	,	,	PUNCT
gs-4062	1129	13	gazzard	gazzard	NOUN
gs-4062	1129	14	b	b	NOUN
gs-4062	1129	15	,	,	PUNCT
gs-4062	1129	16	clotet	clotet	NOUN
gs-4062	1129	17	b	b	NOUN
gs-4062	1129	18	,	,	PUNCT
gs-4062	1129	19	et	et	PROPN
gs-4062	1129	20	al	al	PROPN
gs-4062	1129	21	.	.	PUNCT
gs-4062	1130	1	the	the	DET
gs-4062	1130	2	safety	safety	NOUN
gs-4062	1130	3	of	of	ADP
gs-4062	1130	4	tenofovir	tenofovir	NOUN
gs-4062	1130	5	disoproxil	disoproxil	VERB
gs-4062	1130	6	fumarate	fumarate	NOUN
gs-4062	1130	7	for	for	ADP
gs-4062	1130	8	the	the	DET
gs-4062	1130	9	treatment	treatment	NOUN
gs-4062	1130	10	of	of	ADP
gs-4062	1130	11	hiv	hiv	PROPN
gs-4062	1130	12	infection	infection	NOUN
gs-4062	1130	13	in	in	ADP
gs-4062	1130	14	adults	adult	NOUN
gs-4062	1130	15	:	:	PUNCT
gs-4062	1130	16	the	the	DET
gs-4062	1130	17	first	first	ADJ
gs-4062	1130	18	4	4	NUM
gs-4062	1130	19	years	year	NOUN
gs-4062	1130	20	.	.	PUNCT
gs-4062	1131	1	aids	aids	PROPN
gs-4062	1131	2	.	.	PUNCT
gs-4062	1132	1	2007	2007	NUM
gs-4062	1132	2	jul	jul	PROPN
gs-4062	1132	3	31;21(10):1273	31;21(10):1273	NUM
gs-4062	1132	4	-	-	PUNCT
gs-4062	1132	5	81	81	NUM
gs-4062	1132	6	.	.	PUNCT
gs-4062	1133	1	39	39	NUM
gs-4062	1133	2	.	.	PUNCT
gs-4062	1134	1	sulashvili	sulashvili	NOUN
gs-4062	1134	2	,	,	PUNCT
gs-4062	1134	3	n.	n.	NOUN
gs-4062	1134	4	,	,	PUNCT
gs-4062	1134	5	gorgaslidze	gorgaslidze	PROPN
gs-4062	1134	6	,	,	PUNCT
gs-4062	1134	7	n.	n.	NOUN
gs-4062	1134	8	,	,	PUNCT
gs-4062	1134	9	gabunia	gabunia	NOUN
gs-4062	1134	10	,	,	PUNCT
gs-4062	1134	11	l.	l.	PROPN
gs-4062	1134	12	,	,	PUNCT
gs-4062	1134	13	giorgobiani	giorgobiani	PROPN
gs-4062	1134	14	,	,	PUNCT
gs-4062	1134	15	m.	m.	NOUN
gs-4062	1134	16	,	,	PUNCT
gs-4062	1134	17	&	&	CCONJ
gs-4062	1134	18	ratiani	ratiani	PROPN
gs-4062	1134	19	,	,	PUNCT
gs-4062	1134	20	l.	l.	PROPN
gs-4062	1134	21	(	(	PUNCT
gs-4062	1134	22	2023	2023	NUM
gs-4062	1134	23	)	)	PUNCT
gs-4062	1134	24	.	.	PUNCT
gs-4062	1135	1	manifestation	manifestation	NOUN
gs-4062	1135	2	of	of	ADP
gs-4062	1135	3	the	the	DET
gs-4062	1135	4	particularities	particularity	NOUN
gs-4062	1135	5	of	of	ADP
gs-4062	1135	6	the	the	DET
gs-4062	1135	7	usage	usage	NOUN
gs-4062	1135	8	features	feature	NOUN
gs-4062	1135	9	of	of	ADP
gs-4062	1135	10	monoclonal	monoclonal	NOUN
gs-4062	1135	11	antibodies	antibody	NOUN
gs-4062	1135	12	in	in	ADP
gs-4062	1135	13	various	various	ADJ
gs-4062	1135	14	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-4062	1135	15	applications	application	NOUN
gs-4062	1135	16	.	.	PUNCT
gs-4062	1136	1	experimental	experimental	ADJ
gs-4062	1136	2	and	and	CCONJ
gs-4062	1136	3	clinical	clinical	ADJ
gs-4062	1136	4	medicine	medicine	NOUN
gs-4062	1136	5	georgia	georgia	PROPN
gs-4062	1136	6	,	,	PUNCT
gs-4062	1136	7	(	(	PUNCT
gs-4062	1136	8	4	4	NUM
gs-4062	1136	9	)	)	PUNCT
gs-4062	1136	10	,	,	PUNCT
gs-4062	1136	11	52–57	52–57	NUM
gs-4062	1136	12	.	.	PROPN
gs-4062	1137	1	40	40	NUM
gs-4062	1137	2	.	.	PUNCT
gs-4062	1137	3	sulashvili	sulashvili	NOUN
gs-4062	1137	4	,	,	PUNCT
gs-4062	1137	5	n.	n.	NOUN
gs-4062	1137	6	,	,	PUNCT
gs-4062	1137	7	davitashvili	davitashvili	ADJ
gs-4062	1137	8	,	,	PUNCT
gs-4062	1137	9	m.	m.	NOUN
gs-4062	1137	10	,	,	PUNCT
gs-4062	1137	11	gorgaslidze	gorgaslidze	PROPN
gs-4062	1137	12	,	,	PUNCT
gs-4062	1137	13	n.	n.	NOUN
gs-4062	1137	14	,	,	PUNCT
gs-4062	1137	15	gabunia	gabunia	NOUN
gs-4062	1137	16	,	,	PUNCT
gs-4062	1137	17	l.	l.	PROPN
gs-4062	1137	18	,	,	PUNCT
gs-4062	1137	19	beglaryan	beglaryan	ADJ
gs-4062	1137	20	,	,	PUNCT
gs-4062	1137	21	m.	m.	NOUN
gs-4062	1137	22	,	,	PUNCT
gs-4062	1137	23	alavidze	alavidze	NOUN
gs-4062	1137	24	,	,	PUNCT
gs-4062	1137	25	n.	n.	NOUN
gs-4062	1137	26	,	,	PUNCT
gs-4062	1137	27	…	…	PUNCT
gs-4062	1137	28	sulashvili	sulashvili	NOUN
gs-4062	1137	29	,	,	PUNCT
gs-4062	1137	30	m.	m.	NOUN
gs-4062	1137	31	(	(	PUNCT
gs-4062	1137	32	2024	2024	NUM
gs-4062	1137	33	)	)	PUNCT
gs-4062	1137	34	.	.	PUNCT
gs-4062	1138	1	the	the	DET
gs-4062	1138	2	scientific	scientific	ADJ
gs-4062	1138	3	discussion	discussion	NOUN
gs-4062	1138	4	of	of	ADP
gs-4062	1138	5	some	some	DET
gs-4062	1138	6	issues	issue	NOUN
gs-4062	1138	7	of	of	ADP
gs-4062	1138	8	features	feature	NOUN
gs-4062	1138	9	and	and	CCONJ
gs-4062	1138	10	challenges	challenge	NOUN
gs-4062	1138	11	of	of	ADP
gs-4062	1138	12	using	use	VERB
gs-4062	1138	13	of	of	ADP
gs-4062	1138	14	car	car	NOUN
gs-4062	1138	15	-	-	PUNCT
gs-4062	1138	16	t	t	NOUN
gs-4062	1138	17	cells	cell	NOUN
gs-4062	1138	18	in	in	ADP
gs-4062	1138	19	immunotherapy	immunotherapy	NOUN
gs-4062	1138	20	.	.	PUNCT
gs-4062	1139	1	georgian	georgian	ADJ
gs-4062	1139	2	scientists	scientist	NOUN
gs-4062	1139	3	,	,	PUNCT
gs-4062	1139	4	6(4	6(4	NOUN
gs-4062	1139	5	)	)	PUNCT
gs-4062	1139	6	,	,	PUNCT
gs-4062	1139	7	263–290	263–290	NUM
gs-4062	1139	8	.	.	PUNCT
gs-4062	1140	1	https://doi.org/10.52340/gs.2024.06.04.24	https://doi.org/10.52340/gs.2024.06.04.24	PROPN
gs-4062	1140	2	41	41	NUM
gs-4062	1140	3	.	.	PUNCT
gs-4062	1141	1	sulashvili	sulashvili	NOUN
gs-4062	1141	2	,	,	PUNCT
gs-4062	1141	3	n.	n.	NOUN
gs-4062	1141	4	,	,	PUNCT
gs-4062	1141	5	gorgaslidze	gorgaslidze	PROPN
gs-4062	1141	6	,	,	PUNCT
gs-4062	1141	7	n.	n.	NOUN
gs-4062	1141	8	,	,	PUNCT
gs-4062	1141	9	gabunia	gabunia	NOUN
gs-4062	1141	10	,	,	PUNCT
gs-4062	1141	11	l.	l.	PROPN
gs-4062	1141	12	,	,	PUNCT
gs-4062	1141	13	giorgobiani	giorgobiani	PROPN
gs-4062	1141	14	,	,	PUNCT
gs-4062	1141	15	m.	m.	NOUN
gs-4062	1141	16	,	,	PUNCT
gs-4062	1141	17	&	&	CCONJ
gs-4062	1141	18	ratiani	ratiani	PROPN
gs-4062	1141	19	,	,	PUNCT
gs-4062	1141	20	l.	l.	PROPN
gs-4062	1141	21	(	(	PUNCT
gs-4062	1141	22	2023	2023	NUM
gs-4062	1141	23	)	)	PUNCT
gs-4062	1141	24	.	.	PUNCT
gs-4062	1142	1	manifestation	manifestation	NOUN
gs-4062	1142	2	of	of	ADP
gs-4062	1142	3	the	the	DET
gs-4062	1142	4	particularities	particularity	NOUN
gs-4062	1142	5	of	of	ADP
gs-4062	1142	6	the	the	DET
gs-4062	1142	7	usage	usage	NOUN
gs-4062	1142	8	features	feature	NOUN
gs-4062	1142	9	of	of	ADP
gs-4062	1142	10	monoclonal	monoclonal	NOUN
gs-4062	1142	11	antibodies	antibody	NOUN
gs-4062	1142	12	in	in	ADP
gs-4062	1142	13	various	various	ADJ
gs-4062	1142	14	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-4062	1142	15	applications	application	NOUN
gs-4062	1142	16	.	.	PUNCT
gs-4062	1143	1	experimental	experimental	ADJ
gs-4062	1143	2	and	and	CCONJ
gs-4062	1143	3	clinical	clinical	ADJ
gs-4062	1143	4	medicine	medicine	NOUN
gs-4062	1143	5	georgia	georgia	PROPN
gs-4062	1143	6	,	,	PUNCT
gs-4062	1143	7	(	(	PUNCT
gs-4062	1143	8	4	4	NUM
gs-4062	1143	9	)	)	PUNCT
gs-4062	1143	10	,	,	PUNCT
gs-4062	1143	11	52–57	52–57	NUM
gs-4062	1143	12	.	.	PUNCT
gs-4062	1144	1	https://doi.org/10.52340/jecm.2023.04.14	https://doi.org/10.52340/jecm.2023.04.14	X
gs-4062	1145	1	42	42	NUM
gs-4062	1145	2	.	.	PUNCT
gs-4062	1145	3	sulashvili	sulashvili	NOUN
gs-4062	1145	4	,	,	PUNCT
gs-4062	1145	5	n.	n.	NOUN
gs-4062	1145	6	,	,	PUNCT
gs-4062	1145	7	gorgaslidze	gorgaslidze	PROPN
gs-4062	1145	8	,	,	PUNCT
gs-4062	1145	9	n.	n.	NOUN
gs-4062	1145	10	,	,	PUNCT
gs-4062	1145	11	gabunia	gabunia	NOUN
gs-4062	1145	12	,	,	PUNCT
gs-4062	1145	13	l.	l.	PROPN
gs-4062	1145	14	,	,	PUNCT
gs-4062	1145	15	ratiani	ratiani	PROPN
gs-4062	1145	16	,	,	PUNCT
gs-4062	1145	17	l.	l.	PROPN
gs-4062	1145	18	,	,	PUNCT
gs-4062	1145	19	khetsuriani	khetsuriani	PROPN
gs-4062	1145	20	,	,	PUNCT
gs-4062	1145	21	s.	s.	PROPN
gs-4062	1145	22	,	,	PUNCT
gs-4062	1145	23	kravchenko	kravchenko	PROPN
gs-4062	1145	24	,	,	PUNCT
gs-4062	1145	25	v.	v.	NOUN
gs-4062	1145	26	,	,	PUNCT
gs-4062	1145	27	sulashvili	sulashvili	NOUN
gs-4062	1145	28	,	,	PUNCT
gs-4062	1145	29	m.	m.	NOUN
gs-4062	1145	30	(	(	PUNCT
gs-4062	1145	31	2024	2024	NUM
gs-4062	1145	32	)	)	PUNCT
gs-4062	1145	33	.	.	PUNCT
gs-4062	1146	1	manifestation	manifestation	NOUN
gs-4062	1146	2	of	of	ADP
gs-4062	1146	3	the	the	DET
gs-4062	1146	4	georgian	georgian	NOUN
gs-4062	1146	5	scientists/	scientists/	NUM
gs-4062	1146	6	.	.	PUNCT
gs-4062	1147	1	7	7	NUM
gs-4062	1147	2	n	n	PRON
gs-4062	1147	3	3	3	NUM
gs-4062	1147	4	,	,	PUNCT
gs-4062	1147	5	2025	2025	NUM
gs-4062	1147	6	566	566	NUM
gs-4062	1147	7	particularities	particularity	NOUN
gs-4062	1147	8	of	of	ADP
gs-4062	1147	9	some	some	DET
gs-4062	1147	10	key	key	ADJ
gs-4062	1147	11	issue	issue	NOUN
gs-4062	1147	12	aspects	aspect	NOUN
gs-4062	1147	13	of	of	ADP
gs-4062	1147	14	new	new	ADJ
gs-4062	1147	15	immunotherapy	immunotherapy	NOUN
gs-4062	1147	16	challenges	challenge	NOUN
gs-4062	1147	17	and	and	CCONJ
gs-4062	1147	18	perspectives	perspective	NOUN
gs-4062	1147	19	by	by	ADP
gs-4062	1147	20	car	car	NOUN
gs-4062	1147	21	-	-	PUNCT
gs-4062	1147	22	t	t	NOUN
gs-4062	1147	23	cell	cell	NOUN
gs-4062	1147	24	therapy	therapy	NOUN
gs-4062	1147	25	.	.	PUNCT
gs-4062	1148	1	experimental	experimental	ADJ
gs-4062	1148	2	and	and	CCONJ
gs-4062	1148	3	clinical	clinical	ADJ
gs-4062	1148	4	medicine	medicine	NOUN
gs-4062	1148	5	georgia	georgia	PROPN
gs-4062	1148	6	,	,	PUNCT
gs-4062	1148	7	(	(	PUNCT
gs-4062	1148	8	4	4	NUM
gs-4062	1148	9	)	)	PUNCT
gs-4062	1148	10	,	,	PUNCT
gs-4062	1148	11	119–121	119–121	NUM
gs-4062	1148	12	.	.	PUNCT
gs-4062	1148	13	https://doi.org/10.52340/jecm.2024.04.32	https://doi.org/10.52340/jecm.2024.04.32	NUM
gs-4062	1148	14	.	.	NOUN
gs-4062	1149	1	43	43	NUM
gs-4062	1149	2	.	.	PUNCT
gs-4062	1149	3	sulashvili	sulashvili	NOUN
gs-4062	1149	4	,	,	PUNCT
gs-4062	1149	5	n.	n.	NOUN
gs-4062	1149	6	.	.	PUNCT
gs-4062	1150	1	.	.	PUNCT
gs-4062	1150	2	,	,	PUNCT
gs-4062	1151	1	gorgaslidze	gorgaslidze	INTJ
gs-4062	1151	2	,	,	PUNCT
gs-4062	1151	3	n.	n.	PROPN
gs-4062	1151	4	.	.	PUNCT
gs-4062	1152	1	,	,	PUNCT
gs-4062	1152	2	beglaryan	beglaryan	ADJ
gs-4062	1152	3	,	,	PUNCT
gs-4062	1152	4	m.	m.	NOUN
gs-4062	1152	5	.	.	PUNCT
gs-4062	1152	6	,	,	PUNCT
gs-4062	1152	7	gabunia	gabunia	NOUN
gs-4062	1152	8	,	,	PUNCT
gs-4062	1152	9	l.	l.	PROPN
gs-4062	1152	10	.	.	PROPN
gs-4062	1152	11	,	,	PUNCT
gs-4062	1152	12	chichoyan	chichoyan	PROPN
gs-4062	1152	13	,	,	PUNCT
gs-4062	1152	14	n.	n.	PROPN
gs-4062	1152	15	.	.	PUNCT
gs-4062	1152	16	,	,	PUNCT
gs-4062	1152	17	giorgobiani	giorgobiani	PROPN
gs-4062	1152	18	,	,	PUNCT
gs-4062	1152	19	m.	m.	NOUN
gs-4062	1152	20	.	.	PUNCT
gs-4062	1153	1	,	,	PUNCT
gs-4062	1153	2	…	…	PUNCT
gs-4062	1153	3	zarnadze	zarnadze	INTJ
gs-4062	1153	4	,	,	PUNCT
gs-4062	1153	5	s.	s.	PROPN
gs-4062	1153	6	(	(	PUNCT
gs-4062	1153	7	davit	davit	PROPN
gs-4062	1153	8	)	)	PUNCT
gs-4062	1153	9	.	.	PUNCT
gs-4062	1154	1	(	(	PUNCT
gs-4062	1154	2	2022	2022	NUM
gs-4062	1154	3	)	)	PUNCT
gs-4062	1154	4	.	.	PUNCT
gs-4062	1155	1	the	the	DET
gs-4062	1155	2	scientific	scientific	ADJ
gs-4062	1155	3	talks	talk	NOUN
gs-4062	1155	4	of	of	ADP
gs-4062	1155	5	essential	essential	ADJ
gs-4062	1155	6	issue	issue	NOUN
gs-4062	1155	7	,	,	PUNCT
gs-4062	1155	8	invocation	invocation	NOUN
gs-4062	1155	9	,	,	PUNCT
gs-4062	1155	10	perspectives	perspective	NOUN
gs-4062	1155	11	,	,	PUNCT
gs-4062	1155	12	inclinations	inclination	NOUN
gs-4062	1155	13	and	and	CCONJ
gs-4062	1155	14	features	feature	NOUN
gs-4062	1155	15	of	of	ADP
gs-4062	1155	16	the	the	DET
gs-4062	1155	17	clinical	clinical	ADJ
gs-4062	1155	18	pharmacists	pharmacist	NOUN
gs-4062	1155	19	globally	globally	ADV
gs-4062	1155	20	.	.	PUNCT
gs-4062	1156	1	experimental	experimental	ADJ
gs-4062	1156	2	and	and	CCONJ
gs-4062	1156	3	clinical	clinical	ADJ
gs-4062	1156	4	medicine	medicine	NOUN
gs-4062	1156	5	georgia	georgia	PROPN
gs-4062	1156	6	,	,	PUNCT
gs-4062	1156	7	(	(	PUNCT
gs-4062	1156	8	7	7	NUM
gs-4062	1156	9	)	)	PUNCT
gs-4062	1156	10	.	.	PUNCT
gs-4062	1157	1	44	44	NUM
gs-4062	1157	2	.	.	PUNCT
gs-4062	1158	1	sulashvili	sulashvili	PROPN
gs-4062	1158	2	n	n	CCONJ
gs-4062	1158	3	,	,	PUNCT
gs-4062	1158	4	nimangre	nimangre	PROPN
gs-4062	1158	5	rr	rr	PROPN
gs-4062	1158	6	.	.	PUNCT
gs-4062	1159	1	manifestation	manifestation	NOUN
gs-4062	1159	2	of	of	ADP
gs-4062	1159	3	some	some	DET
gs-4062	1159	4	aspects	aspect	NOUN
gs-4062	1159	5	of	of	ADP
gs-4062	1159	6	cardiovascular	cardiovascular	ADJ
gs-4062	1159	7	diseases	disease	NOUN
gs-4062	1159	8	,	,	PUNCT
gs-4062	1159	9	implications	implication	NOUN
gs-4062	1159	10	,	,	PUNCT
gs-4062	1159	11	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-4062	1159	12	strategies	strategy	NOUN
gs-4062	1159	13	,	,	PUNCT
gs-4062	1159	14	effects	effect	NOUN
gs-4062	1159	15	,	,	PUNCT
gs-4062	1159	16	impacts	impact	NOUN
gs-4062	1159	17	and	and	CCONJ
gs-4062	1159	18	potential	potential	ADJ
gs-4062	1159	19	hazards	hazard	NOUN
gs-4062	1159	20	in	in	ADP
gs-4062	1159	21	general	general	ADJ
gs-4062	1159	22	.	.	PUNCT
gs-4062	1160	1	jr	jr	PROPN
gs-4062	1161	1	[	[	X
gs-4062	1161	2	internet	internet	NOUN
gs-4062	1161	3	]	]	PUNCT
gs-4062	1161	4	.	.	PUNCT
gs-4062	1162	1	2025	2025	NUM
gs-4062	1162	2	feb	feb	X
gs-4062	1162	3	.	.	PROPN
gs-4062	1162	4	7	7	NUM
gs-4062	1162	5	[	[	X
gs-4062	1162	6	cited	cite	VERB
gs-4062	1162	7	2025	2025	NUM
gs-4062	1162	8	may	may	PROPN
gs-4062	1162	9	22];3(1):1	22];3(1):1	NUM
gs-4062	1162	10	-	-	SYM
gs-4062	1162	11	27	27	NUM
gs-4062	1162	12	.	.	PUNCT
gs-4062	1163	1	available	available	ADJ
gs-4062	1163	2	from	from	ADP
gs-4062	1163	3	:	:	PUNCT
gs-4062	1163	4	https://journals.4science.ge/index.php/jr/article/view/3393	https://journals.4science.ge/index.php/jr/article/view/3393	PROPN
gs-4062	1163	5	.	.	PUNCT
gs-4062	1164	1	45	45	NUM
gs-4062	1164	2	.	.	PUNCT
gs-4062	1164	3	sulashvili	sulashvili	PROPN
gs-4062	1164	4	n	n	CCONJ
gs-4062	1164	5	,	,	PUNCT
gs-4062	1164	6	yaduvanshi	yaduvanshi	NOUN
gs-4062	1164	7	u	u	NOUN
gs-4062	1164	8	,	,	PUNCT
gs-4062	1164	9	yadav	yadav	PROPN
gs-4062	1164	10	m	m	PROPN
gs-4062	1164	11	,	,	PUNCT
gs-4062	1164	12	gabunia	gabunia	NOUN
gs-4062	1164	13	l	l	NOUN
gs-4062	1164	14	,	,	PUNCT
gs-4062	1164	15	ghambashidze	ghambashidze	PROPN
gs-4062	1164	16	k	k	PROPN
gs-4062	1164	17	,	,	PUNCT
gs-4062	1164	18	gorgaslidze	gorgaslidze	ADJ
gs-4062	1164	19	n	n	CCONJ
gs-4062	1164	20	,	,	PUNCT
gs-4062	1164	21	et	et	PROPN
gs-4062	1164	22	al	al	PROPN
gs-4062	1164	23	.	.	PUNCT
gs-4062	1165	1	the	the	DET
gs-4062	1165	2	scientific	scientific	ADJ
gs-4062	1165	3	discourse	discourse	NOUN
gs-4062	1165	4	of	of	ADP
gs-4062	1165	5	features	feature	NOUN
gs-4062	1165	6	of	of	ADP
gs-4062	1165	7	clinical	clinical	ADJ
gs-4062	1165	8	use	use	NOUN
gs-4062	1165	9	and	and	CCONJ
gs-4062	1165	10	pharmacology	pharmacology	NOUN
gs-4062	1165	11	of	of	ADP
gs-4062	1165	12	vasoconstrictors	vasoconstrictor	NOUN
gs-4062	1165	13	and	and	CCONJ
gs-4062	1165	14	their	their	PRON
gs-4062	1165	15	impact	impact	NOUN
gs-4062	1165	16	on	on	ADP
gs-4062	1165	17	cardiac	cardiac	ADJ
gs-4062	1165	18	function	function	NOUN
gs-4062	1165	19	.	.	PUNCT
gs-4062	1166	1	jr	jr	PROPN
gs-4062	1167	1	[	[	X
gs-4062	1167	2	internet	internet	NOUN
gs-4062	1167	3	]	]	PUNCT
gs-4062	1167	4	.	.	PUNCT
gs-4062	1168	1	2025	2025	NUM
gs-4062	1168	2	feb	feb	X
gs-4062	1168	3	.	.	PROPN
gs-4062	1168	4	21	21	NUM
gs-4062	1168	5	[	[	X
gs-4062	1168	6	cited	cite	VERB
gs-4062	1168	7	2025	2025	NUM
gs-4062	1168	8	may	may	PROPN
gs-4062	1168	9	22];3(1):28	22];3(1):28	NUM
gs-4062	1168	10	-	-	SYM
gs-4062	1168	11	6	6	NUM
gs-4062	1168	12	.	.	PUNCT
gs-4062	1169	1	available	available	ADJ
gs-4062	1169	2	from	from	ADP
gs-4062	1169	3	:	:	PUNCT
gs-4062	1169	4	https://journals.4science.ge/index.php/jr/article/view/3414	https://journals.4science.ge/index.php/jr/article/view/3414	PROPN
gs-4062	1169	5	.	.	PUNCT
gs-4062	1170	1	46	46	NUM
gs-4062	1170	2	.	.	PUNCT
gs-4062	1171	1	nodar	nodar	PROPN
gs-4062	1171	2	sulashvili	sulashvili	NOUN
gs-4062	1171	3	,	,	PUNCT
gs-4062	1171	4	nana	nana	PROPN
gs-4062	1171	5	gorgaslidze	gorgaslidze	PROPN
gs-4062	1171	6	,	,	PUNCT
gs-4062	1171	7	margarita	margarita	PROPN
gs-4062	1171	8	beglaryan	beglaryan	PROPN
gs-4062	1171	9	,	,	PUNCT
gs-4062	1171	10	luiza	luiza	PROPN
gs-4062	1171	11	gabunia	gabunia	PROPN
gs-4062	1171	12	,	,	PUNCT
gs-4062	1171	13	nato	nato	PROPN
gs-4062	1171	14	alavidze	alavidze	PROPN
gs-4062	1171	15	,	,	PUNCT
gs-4062	1171	16	nino	nino	PROPN
gs-4062	1171	17	abuladze	abuladze	PROPN
gs-4062	1171	18	,	,	PUNCT
gs-4062	1171	19	marina	marina	PROPN
gs-4062	1171	20	giorgobiani	giorgobiani	PROPN
gs-4062	1171	21	,	,	PUNCT
gs-4062	1171	22	marika	marika	PROPN
gs-4062	1171	23	sulashvili	sulashvili	PROPN
gs-4062	1171	24	,	,	PUNCT
gs-4062	1171	25	tamar	tamar	PROPN
gs-4062	1171	26	okropiridze	okropiridze	PROPN
gs-4062	1171	27	,	,	PUNCT
gs-4062	1171	28	and	and	CCONJ
gs-4062	1171	29	lali	lali	PROPN
gs-4062	1171	30	patsia	patsia	PROPN
gs-4062	1171	31	.	.	PUNCT
gs-4062	1172	1	2025	2025	NUM
gs-4062	1172	2	.	.	PUNCT
gs-4062	1173	1	“	"	PUNCT
gs-4062	1173	2	the	the	DET
gs-4062	1173	3	scientific	scientific	ADJ
gs-4062	1173	4	discourse	discourse	NOUN
gs-4062	1173	5	of	of	ADP
gs-4062	1173	6	key	key	ADJ
gs-4062	1173	7	issue	issue	NOUN
gs-4062	1173	8	aspects	aspect	NOUN
gs-4062	1173	9	of	of	ADP
gs-4062	1173	10	features	feature	NOUN
gs-4062	1173	11	of	of	ADP
gs-4062	1173	12	candida	candida	PROPN
gs-4062	1173	13	problems	problem	NOUN
gs-4062	1173	14	,	,	PUNCT
gs-4062	1173	15	antifungal	antifungal	ADJ
gs-4062	1173	16	drugs	drug	NOUN
gs-4062	1173	17	resistance	resistance	NOUN
gs-4062	1173	18	concerns	concern	NOUN
gs-4062	1173	19	,	,	PUNCT
gs-4062	1173	20	mycotoxicology	mycotoxicology	NOUN
gs-4062	1173	21	issues	issue	NOUN
gs-4062	1173	22	,	,	PUNCT
gs-4062	1173	23	mycoecology	mycoecology	NOUN
gs-4062	1173	24	,	,	PUNCT
gs-4062	1173	25	biosafety	biosafety	NOUN
gs-4062	1173	26	risks	risk	NOUN
gs-4062	1173	27	and	and	CCONJ
gs-4062	1173	28	emerging	emerge	VERB
gs-4062	1173	29	solutions	solution	NOUN
gs-4062	1173	30	”	"	PUNCT
gs-4062	1173	31	.	.	PUNCT
gs-4062	1174	1	modern	modern	ADJ
gs-4062	1174	2	scientific	scientific	ADJ
gs-4062	1174	3	method	method	NOUN
gs-4062	1174	4	,	,	PUNCT
gs-4062	1174	5	no	no	INTJ
gs-4062	1174	6	.	.	NOUN
gs-4062	1174	7	9	9	NUM
gs-4062	1174	8	(	(	PUNCT
gs-4062	1174	9	march	march	PROPN
gs-4062	1174	10	)	)	PUNCT
gs-4062	1174	11	.	.	PUNCT
gs-4062	1175	1	https://ojs.scipub.de/index.php/msm/article/view/5423	https://ojs.scipub.de/index.php/msm/article/view/5423	NOUN
gs-4062	1175	2	.	.	PUNCT
gs-4062	1176	1	47	47	NUM
gs-4062	1176	2	.	.	PUNCT
gs-4062	1177	1	aphkhazava	aphkhazava	PROPN
gs-4062	1177	2	,	,	PUNCT
gs-4062	1177	3	d.	d.	PROPN
gs-4062	1177	4	,	,	PUNCT
gs-4062	1177	5	tuphinashvili	tuphinashvili	NOUN
gs-4062	1177	6	,	,	PUNCT
gs-4062	1177	7	t.	t.	NOUN
gs-4062	1177	8	,	,	PUNCT
gs-4062	1177	9	sulashvili	sulashvili	NOUN
gs-4062	1177	10	,	,	PUNCT
gs-4062	1177	11	n.	n.	NOUN
gs-4062	1177	12	,	,	PUNCT
gs-4062	1177	13	&	&	CCONJ
gs-4062	1177	14	nozadze	nozadze	NOUN
gs-4062	1177	15	,	,	PUNCT
gs-4062	1177	16	m.	m.	NOUN
gs-4062	1177	17	(	(	PUNCT
gs-4062	1177	18	2023	2023	NUM
gs-4062	1177	19	)	)	PUNCT
gs-4062	1177	20	.	.	PUNCT
gs-4062	1178	1	the	the	DET
gs-4062	1178	2	features	feature	NOUN
gs-4062	1178	3	and	and	CCONJ
gs-4062	1178	4	role	role	NOUN
gs-4062	1178	5	of	of	ADP
gs-4062	1178	6	shp2	shp2	ADJ
gs-4062	1178	7	protein	protein	NOUN
gs-4062	1178	8	in	in	ADP
gs-4062	1178	9	postnatal	postnatal	ADJ
gs-4062	1178	10	muscle	muscle	NOUN
gs-4062	1178	11	development	development	NOUN
gs-4062	1178	12	.	.	PUNCT
gs-4062	1179	1	scientific	scientific	ADJ
gs-4062	1179	2	journal	journal	NOUN
gs-4062	1179	3	„	„	PUNCT
gs-4062	1179	4	spectri	spectri	NOUN
gs-4062	1179	5	“	"	PUNCT
gs-4062	1179	6	,	,	PUNCT
gs-4062	1179	7	1	1	X
gs-4062	1179	8	.	.	PUNCT
gs-4062	1180	1	https://doi.org/10.52340/spectri.2023.01	https://doi.org/10.52340/spectri.2023.01	DET
gs-4062	1180	2	48	48	NUM
gs-4062	1180	3	.	.	PUNCT
gs-4062	1181	1	sulashvili	sulashvili	NOUN
gs-4062	1181	2	,	,	PUNCT
gs-4062	1181	3	n.	n.	NOUN
gs-4062	1181	4	,	,	PUNCT
gs-4062	1181	5	beglaryan	beglaryan	ADJ
gs-4062	1181	6	,	,	PUNCT
gs-4062	1181	7	m.	m.	NOUN
gs-4062	1181	8	,	,	PUNCT
gs-4062	1181	9	gorgaslidze	gorgaslidze	PROPN
gs-4062	1181	10	,	,	PUNCT
gs-4062	1181	11	n.	n.	PROPN
gs-4062	1181	12	,	,	PUNCT
gs-4062	1181	13	kocharyan	kocharyan	PROPN
gs-4062	1181	14	,	,	PUNCT
gs-4062	1181	15	s.	s.	PROPN
gs-4062	1181	16	,	,	PUNCT
gs-4062	1181	17	chichoyan	chichoyan	PROPN
gs-4062	1181	18	,	,	PUNCT
gs-4062	1181	19	n.	n.	NOUN
gs-4062	1181	20	,	,	PUNCT
gs-4062	1181	21	gabunia	gabunia	NOUN
gs-4062	1181	22	,	,	PUNCT
gs-4062	1181	23	l.	l.	PROPN
gs-4062	1181	24	,	,	PUNCT
gs-4062	1181	25	zarnadze	zarnadze	PROPN
gs-4062	1181	26	,	,	PUNCT
gs-4062	1181	27	s.	s.	PROPN
gs-4062	1181	28	(	(	PUNCT
gs-4062	1181	29	davit	davit	PROPN
gs-4062	1181	30	)	)	PUNCT
gs-4062	1181	31	.	.	PUNCT
gs-4062	1182	1	(	(	PUNCT
gs-4062	1182	2	2023	2023	NUM
gs-4062	1182	3	)	)	PUNCT
gs-4062	1182	4	.	.	PUNCT
gs-4062	1183	1	the	the	DET
gs-4062	1183	2	disclosure	disclosure	NOUN
gs-4062	1183	3	of	of	ADP
gs-4062	1183	4	features	feature	NOUN
gs-4062	1183	5	,	,	PUNCT
gs-4062	1183	6	characteristics	characteristic	NOUN
gs-4062	1183	7	,	,	PUNCT
gs-4062	1183	8	possibilities	possibility	NOUN
gs-4062	1183	9	and	and	CCONJ
gs-4062	1183	10	specialties	specialty	NOUN
gs-4062	1183	11	of	of	ADP
gs-4062	1183	12	clinical	clinical	ADJ
gs-4062	1183	13	pharmacists	pharmacist	NOUN
gs-4062	1183	14	as	as	ADP
gs-4062	1183	15	mediator	mediator	NOUN
gs-4062	1183	16	among	among	ADP
gs-4062	1183	17	doctors	doctor	NOUN
gs-4062	1183	18	and	and	CCONJ
gs-4062	1183	19	patients	patient	NOUN
gs-4062	1183	20	for	for	ADP
gs-4062	1183	21	enhancement	enhancement	NOUN
gs-4062	1183	22	public	public	ADJ
gs-4062	1183	23	health	health	NOUN
gs-4062	1183	24	sector	sector	NOUN
gs-4062	1183	25	in	in	ADP
gs-4062	1183	26	a	a	DET
gs-4062	1183	27	global	global	ADJ
gs-4062	1183	28	world	world	NOUN
gs-4062	1183	29	.	.	PUNCT
gs-4062	1184	1	experimental	experimental	ADJ
gs-4062	1184	2	and	and	CCONJ
gs-4062	1184	3	clinical	clinical	ADJ
gs-4062	1184	4	medicine	medicine	NOUN
gs-4062	1184	5	georgia	georgia	PROPN
gs-4062	1184	6	,	,	PUNCT
gs-4062	1184	7	(	(	PUNCT
gs-4062	1184	8	4	4	NUM
gs-4062	1184	9	)	)	PUNCT
gs-4062	1184	10	,	,	PUNCT
gs-4062	1184	11	57–62	57–62	NUM
gs-4062	1184	12	.	.	PUNCT
gs-4062	1184	13	https://doi.org/10.52340/jecm.2023.04.15	https://doi.org/10.52340/jecm.2023.04.15	PROPN
gs-4062	1184	14	49	49	NUM
gs-4062	1184	15	.	.	PUNCT
gs-4062	1185	1	sulashvili	sulashvili	PROPN
gs-4062	1185	2	n	n	CCONJ
gs-4062	1185	3	,	,	PUNCT
gs-4062	1185	4	davitashvili	davitashvili	PROPN
gs-4062	1185	5	m	m	PROPN
gs-4062	1185	6	,	,	PUNCT
gs-4062	1185	7	gorgaslidze	gorgaslidze	ADJ
gs-4062	1185	8	n	n	CCONJ
gs-4062	1185	9	,	,	PUNCT
gs-4062	1185	10	gabunia	gabunia	NOUN
gs-4062	1185	11	l	l	NOUN
gs-4062	1185	12	,	,	PUNCT
gs-4062	1185	13	beglaryan	beglaryan	PROPN
gs-4062	1185	14	m	m	PROPN
gs-4062	1185	15	,	,	PUNCT
gs-4062	1185	16	alavidze	alavidze	PROPN
gs-4062	1185	17	n	n	CCONJ
gs-4062	1185	18	,	,	PUNCT
gs-4062	1185	19	et	et	PROPN
gs-4062	1185	20	al	al	PROPN
gs-4062	1185	21	.	.	PUNCT
gs-4062	1186	1	the	the	DET
gs-4062	1186	2	scientific	scientific	ADJ
gs-4062	1186	3	discussion	discussion	NOUN
gs-4062	1186	4	of	of	ADP
gs-4062	1186	5	some	some	DET
gs-4062	1186	6	issues	issue	NOUN
gs-4062	1186	7	of	of	ADP
gs-4062	1186	8	features	feature	NOUN
gs-4062	1186	9	and	and	CCONJ
gs-4062	1186	10	challenges	challenge	NOUN
gs-4062	1186	11	of	of	ADP
gs-4062	1186	12	using	use	VERB
gs-4062	1186	13	of	of	ADP
gs-4062	1186	14	car	car	NOUN
gs-4062	1186	15	-	-	PUNCT
gs-4062	1186	16	t	t	NOUN
gs-4062	1186	17	cells	cell	NOUN
gs-4062	1186	18	in	in	ADP
gs-4062	1186	19	immunotherapy	immunotherapy	NOUN
gs-4062	1186	20	.	.	PUNCT
gs-4062	1187	1	gs	gs	PROPN
gs-4062	1187	2	2024	2024	NUM
gs-4062	1187	3	;	;	PUNCT
gs-4062	1187	4	6(4):263	6(4):263	NUM
gs-4062	1187	5	-	-	SYM
gs-4062	1187	6	90	90	NUM
gs-4062	1187	7	.	.	PUNCT
gs-4062	1188	1	https://journals.4science.ge/index.php/gs/article/view/3214	https://journals.4science.ge/index.php/gs/article/view/3214	PROPN
gs-4062	1189	1	50	50	NUM
gs-4062	1189	2	.	.	X
gs-4062	1190	1	aphkhazava	aphkhazava	PROPN
gs-4062	1190	2	,	,	PUNCT
gs-4062	1190	3	david	david	PROPN
gs-4062	1190	4	,	,	PUNCT
gs-4062	1190	5	nodar	nodar	NOUN
gs-4062	1190	6	sulashvili	sulashvili	NOUN
gs-4062	1190	7	,	,	PUNCT
gs-4062	1190	8	and	and	CCONJ
gs-4062	1190	9	jaba	jaba	PROPN
gs-4062	1190	10	tkemaladze	tkemaladze	PROPN
gs-4062	1190	11	.	.	PUNCT
gs-4062	1191	1	2025	2025	NUM
gs-4062	1191	2	.	.	PUNCT
gs-4062	1192	1	“	"	PUNCT
gs-4062	1192	2	stem	stem	NOUN
gs-4062	1192	3	cell	cell	NOUN
gs-4062	1192	4	systems	system	NOUN
gs-4062	1192	5	and	and	CCONJ
gs-4062	1192	6	regeneration	regeneration	NOUN
gs-4062	1192	7	”	"	PUNCT
gs-4062	1192	8	.	.	PUNCT
gs-4062	1193	1	georgian	georgian	PROPN
gs-4062	1193	2	scientists	scientist	NOUN
gs-4062	1193	3	7	7	NUM
gs-4062	1193	4	(	(	PUNCT
gs-4062	1193	5	1):271	1):271	NUM
gs-4062	1193	6	-	-	SYM
gs-4062	1193	7	319	319	NUM
gs-4062	1193	8	.	.	PUNCT
gs-4062	1194	1	https://doi.org/10.52340/gs.2025.07.01.26	https://doi.org/10.52340/gs.2025.07.01.26	NOUN
gs-4062	1194	2	.	.	X
gs-4062	1195	1	51	51	NUM
gs-4062	1195	2	.	.	PUNCT
gs-4062	1196	1	relling	relle	VERB
gs-4062	1196	2	,	,	PUNCT
gs-4062	1196	3	mary	mary	PROPN
gs-4062	1196	4	v.	v.	PROPN
gs-4062	1196	5	,	,	PUNCT
gs-4062	1196	6	and	and	CCONJ
gs-4062	1196	7	william	william	PROPN
gs-4062	1196	8	e.	e.	PROPN
gs-4062	1196	9	evans	evans	PROPN
gs-4062	1196	10	.	.	PROPN
gs-4062	1196	11	2015	2015	NUM
gs-4062	1196	12	.	.	PUNCT
gs-4062	1197	1	“	"	PUNCT
gs-4062	1197	2	pharmacogenomics	pharmacogenomic	NOUN
gs-4062	1197	3	in	in	ADP
gs-4062	1197	4	the	the	DET
gs-4062	1197	5	clinic	clinic	NOUN
gs-4062	1197	6	.	.	PUNCT
gs-4062	1197	7	”	"	PUNCT
gs-4062	1198	1	nature	nature	NOUN
gs-4062	1198	2	526	526	NUM
gs-4062	1198	3	(	(	PUNCT
gs-4062	1198	4	7573	7573	NUM
gs-4062	1198	5	):	):	PUNCT
gs-4062	1198	6	343–50	343–50	NUM
gs-4062	1198	7	.	.	PUNCT
gs-4062	1199	1	52	52	NUM
gs-4062	1199	2	.	.	PUNCT
gs-4062	1200	1	aphkhazava	aphkhazava	PROPN
gs-4062	1200	2	,	,	PUNCT
gs-4062	1200	3	david	david	PROPN
gs-4062	1200	4	,	,	PUNCT
gs-4062	1200	5	tamar	tamar	PROPN
gs-4062	1200	6	tuphinashvili	tuphinashvili	PROPN
gs-4062	1200	7	,	,	PUNCT
gs-4062	1200	8	nodar	nodar	NOUN
gs-4062	1200	9	sulashvili	sulashvili	NOUN
gs-4062	1200	10	,	,	PUNCT
gs-4062	1200	11	and	and	CCONJ
gs-4062	1200	12	maia	maia	NOUN
gs-4062	1200	13	nozadze	nozadze	NOUN
gs-4062	1200	14	.	.	PUNCT
gs-4062	1201	1	2023	2023	NUM
gs-4062	1201	2	.	.	PUNCT
gs-4062	1202	1	“	"	PUNCT
gs-4062	1202	2	the	the	DET
gs-4062	1202	3	features	feature	NOUN
gs-4062	1202	4	and	and	CCONJ
gs-4062	1202	5	role	role	NOUN
gs-4062	1202	6	of	of	ADP
gs-4062	1202	7	shp2	shp2	ADJ
gs-4062	1202	8	protein	protein	NOUN
gs-4062	1202	9	in	in	ADP
gs-4062	1202	10	postnatal	postnatal	ADJ
gs-4062	1202	11	muscle	muscle	NOUN
gs-4062	1202	12	development	development	NOUN
gs-4062	1202	13	”	"	PUNCT
gs-4062	1202	14	.	.	PUNCT
gs-4062	1203	1	scientific	scientific	ADJ
gs-4062	1203	2	journal	journal	NOUN
gs-4062	1203	3	„	„	PUNCT
gs-4062	1203	4	spectri	spectri	ADJ
gs-4062	1203	5	“	"	PUNCT
gs-4062	1203	6	1	1	NUM
gs-4062	1203	7	(	(	PUNCT
gs-4062	1203	8	march	march	PROPN
gs-4062	1203	9	)	)	PUNCT
gs-4062	1203	10	.	.	PUNCT
gs-4062	1204	1	https://doi.org/10.52340/spectri.2023.01	https://doi.org/10.52340/spectri.2023.01	PROPN
gs-4062	1204	2	.	.	PUNCT
gs-4062	1205	1	georgian	georgian	NOUN
gs-4062	1205	2	scientists/	scientists/	NUM
gs-4062	1205	3	.	.	PUNCT
gs-4062	1206	1	7	7	NUM
gs-4062	1206	2	n	n	PRON
gs-4062	1206	3	3	3	NUM
gs-4062	1206	4	,	,	PUNCT
gs-4062	1206	5	2025	2025	NUM
gs-4062	1206	6	567	567	NUM
gs-4062	1206	7	53	53	NUM
gs-4062	1206	8	.	.	PUNCT
gs-4062	1207	1	sulashvili	sulashvili	PROPN
gs-4062	1207	2	n	n	CCONJ
gs-4062	1207	3	,	,	PUNCT
gs-4062	1207	4	gorgaslidze	gorgaslidze	ADJ
gs-4062	1207	5	n	n	CCONJ
gs-4062	1207	6	,	,	PUNCT
gs-4062	1207	7	gabunia	gabunia	NOUN
gs-4062	1207	8	l	l	NOUN
gs-4062	1207	9	,	,	PUNCT
gs-4062	1207	10	giorgobiani	giorgobiani	PROPN
gs-4062	1207	11	m	m	PROPN
gs-4062	1207	12	,	,	PUNCT
gs-4062	1207	13	ratiani	ratiani	PROPN
gs-4062	1207	14	l.	l.	PROPN
gs-4062	1207	15	manifestation	manifestation	PROPN
gs-4062	1207	16	of	of	ADP
gs-4062	1207	17	the	the	DET
gs-4062	1207	18	particularities	particularity	NOUN
gs-4062	1207	19	of	of	ADP
gs-4062	1207	20	the	the	DET
gs-4062	1207	21	usage	usage	NOUN
gs-4062	1207	22	features	feature	NOUN
gs-4062	1207	23	of	of	ADP
gs-4062	1207	24	monoclonal	monoclonal	NOUN
gs-4062	1207	25	antibodies	antibody	NOUN
gs-4062	1207	26	in	in	ADP
gs-4062	1207	27	various	various	ADJ
gs-4062	1207	28	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-4062	1207	29	applications	application	NOUN
gs-4062	1207	30	.	.	PUNCT
gs-4062	1208	1	jecmg	jecmg	NOUN
gs-4062	1209	1	[	[	X
gs-4062	1209	2	internet	internet	NOUN
gs-4062	1209	3	]	]	X
gs-4062	1209	4	.	.	PUNCT
gs-4062	1210	1	2023	2023	NUM
gs-4062	1210	2	nov	nov	PROPN
gs-4062	1210	3	.	.	PROPN
gs-4062	1210	4	26	26	NUM
gs-4062	1210	5	[	[	X
gs-4062	1210	6	cited	cite	VERB
gs-4062	1210	7	2025	2025	NUM
gs-4062	1210	8	jul	jul	PROPN
gs-4062	1210	9	.	.	PROPN
gs-4062	1210	10	12];(4):52	12];(4):52	NUM
gs-4062	1210	11	-	-	SYM
gs-4062	1210	12	7	7	NUM
gs-4062	1210	13	.	.	PUNCT
gs-4062	1210	14	available	available	ADJ
gs-4062	1210	15	from	from	ADP
gs-4062	1210	16	:	:	PUNCT
gs-4062	1210	17	https://journals.4science.ge/index.php/jecm/article/view/2413	https://journals.4science.ge/index.php/jecm/article/view/2413	PROPN
gs-4062	1210	18	.	.	PROPN
gs-4062	1211	1	54	54	NUM
gs-4062	1211	2	.	.	X
gs-4062	1212	1	aphkhazava	aphkhazava	PROPN
gs-4062	1212	2	,	,	PUNCT
gs-4062	1212	3	david	david	PROPN
gs-4062	1212	4	,	,	PUNCT
gs-4062	1212	5	nodar	nodar	PROPN
gs-4062	1212	6	sulashvili	sulashvili	NOUN
gs-4062	1212	7	,	,	PUNCT
gs-4062	1212	8	ia	ia	PROPN
gs-4062	1212	9	egnatievi	egnatievi	PROPN
gs-4062	1212	10	,	,	PUNCT
gs-4062	1212	11	manana	manana	PROPN
gs-4062	1212	12	giorgobiani	giorgobiani	PROPN
gs-4062	1212	13	,	,	PUNCT
gs-4062	1212	14	maia	maia	PROPN
gs-4062	1212	15	nozadze	nozadze	PROPN
gs-4062	1212	16	,	,	PUNCT
gs-4062	1212	17	nani	nani	PROPN
gs-4062	1212	18	vekua	vekua	NOUN
gs-4062	1212	19	,	,	PUNCT
gs-4062	1212	20	and	and	CCONJ
gs-4062	1212	21	nino	nino	PROPN
gs-4062	1212	22	japaridze	japaridze	PROPN
gs-4062	1212	23	.	.	PUNCT
gs-4062	1213	1	2024	2024	NUM
gs-4062	1213	2	.	.	PUNCT
gs-4062	1214	1	“	"	PUNCT
gs-4062	1214	2	derivation	derivation	NOUN
gs-4062	1214	3	of	of	ADP
gs-4062	1214	4	ampa	ampa	NOUN
gs-4062	1214	5	receptor	receptor	NOUN
gs-4062	1214	6	glua1	glua1	NOUN
gs-4062	1214	7	subunits	subunit	NOUN
gs-4062	1214	8	in	in	ADP
gs-4062	1214	9	mice	mouse	NOUN
gs-4062	1214	10	from	from	ADP
gs-4062	1214	11	exosomes	exosome	NOUN
gs-4062	1214	12	modulates	modulate	NOUN
gs-4062	1214	13	inflammatory	inflammatory	ADJ
gs-4062	1214	14	pain	pain	NOUN
gs-4062	1214	15	”	"	PUNCT
gs-4062	1214	16	.	.	PUNCT
gs-4062	1215	1	scientific	scientific	ADJ
gs-4062	1215	2	journal	journal	NOUN
gs-4062	1215	3	„	„	PUNCT
gs-4062	1215	4	spectri	spectri	ADJ
gs-4062	1215	5	“	"	PUNCT
gs-4062	1215	6	9	9	NUM
gs-4062	1215	7	(	(	PUNCT
gs-4062	1215	8	1	1	NUM
gs-4062	1215	9	)	)	PUNCT
gs-4062	1215	10	.	.	PUNCT
gs-4062	1216	1	https://doi.org/10.52340/spectri.2024.09.01.05	https://doi.org/10.52340/spectri.2024.09.01.05	NOUN
gs-4062	1216	2	.	.	PUNCT
gs-4062	1217	1	55	55	NUM
gs-4062	1217	2	.	.	X
gs-4062	1218	1	aphkhazava	aphkhazava	PROPN
gs-4062	1218	2	,	,	PUNCT
gs-4062	1218	3	david	david	PROPN
gs-4062	1218	4	,	,	PUNCT
gs-4062	1218	5	nodar	nodar	PROPN
gs-4062	1218	6	sulashvili	sulashvili	NOUN
gs-4062	1218	7	,	,	PUNCT
gs-4062	1218	8	ia	ia	PROPN
gs-4062	1218	9	egnatievi	egnatievi	PROPN
gs-4062	1218	10	,	,	PUNCT
gs-4062	1218	11	tamar	tamar	PROPN
gs-4062	1218	12	tupinashvili	tupinashvili	NOUN
gs-4062	1218	13	,	,	PUNCT
gs-4062	1218	14	and	and	CCONJ
gs-4062	1218	15	maia	maia	PROPN
gs-4062	1218	16	nozadze	nozadze	PROPN
gs-4062	1218	17	.	.	PUNCT
gs-4062	1219	1	2024	2024	NUM
gs-4062	1219	2	.	.	PUNCT
gs-4062	1220	1	“	"	PUNCT
gs-4062	1220	2	dynamic	dynamic	ADJ
gs-4062	1220	3	tumor	tumor	NOUN
gs-4062	1220	4	microenvironment	microenvironment	NOUN
gs-4062	1220	5	theory	theory	NOUN
gs-4062	1220	6	:	:	PUNCT
gs-4062	1220	7	a	a	DET
gs-4062	1220	8	multifaceted	multifaceted	ADJ
gs-4062	1220	9	approach	approach	NOUN
gs-4062	1220	10	to	to	ADP
gs-4062	1220	11	tumor	tumor	NOUN
gs-4062	1220	12	research	research	NOUN
gs-4062	1220	13	and	and	CCONJ
gs-4062	1220	14	biochemistry	biochemistry	NOUN
gs-4062	1220	15	”	"	PUNCT
gs-4062	1220	16	.	.	PUNCT
gs-4062	1221	1	scientific	scientific	ADJ
gs-4062	1221	2	journal	journal	NOUN
gs-4062	1221	3	„	„	PUNCT
gs-4062	1221	4	spectri	spectri	ADJ
gs-4062	1221	5	“	"	PUNCT
gs-4062	1221	6	9	9	NUM
gs-4062	1221	7	(	(	PUNCT
gs-4062	1221	8	1	1	NUM
gs-4062	1221	9	)	)	PUNCT
gs-4062	1221	10	.	.	PUNCT
gs-4062	1222	1	https://doi.org/10.52340/spectri.2024.09.01.06	https://doi.org/10.52340/spectri.2024.09.01.06	NOUN
gs-4062	1222	2	.	.	PROPN
gs-4062	1222	3	56	56	NUM
gs-4062	1222	4	.	.	PUNCT
gs-4062	1222	5	sulashvili	sulashvili	NOUN
gs-4062	1222	6	,	,	PUNCT
gs-4062	1222	7	nodar	nodar	ADV
gs-4062	1222	8	,	,	PUNCT
gs-4062	1222	9	irine	irine	NOUN
gs-4062	1222	10	pkhakadze	pkhakadze	NOUN
gs-4062	1222	11	,	,	PUNCT
gs-4062	1222	12	margarita	margarita	PROPN
gs-4062	1222	13	beglaryan	beglaryan	NOUN
gs-4062	1222	14	,	,	PUNCT
gs-4062	1222	15	ia	ia	PROPN
gs-4062	1222	16	egnatievi	egnatievi	PROPN
gs-4062	1222	17	,	,	PUNCT
gs-4062	1222	18	manana	manana	PROPN
gs-4062	1222	19	giorgobiani	giorgobiani	PROPN
gs-4062	1222	20	,	,	PUNCT
gs-4062	1222	21	luiza	luiza	PROPN
gs-4062	1222	22	gabunia	gabunia	PROPN
gs-4062	1222	23	,	,	PUNCT
gs-4062	1222	24	nana	nana	PROPN
gs-4062	1222	25	gorgaslidze	gorgaslidze	PROPN
gs-4062	1222	26	,	,	PUNCT
gs-4062	1222	27	magda	magda	PROPN
gs-4062	1222	28	davitashvili	davitashvili	PROPN
gs-4062	1222	29	,	,	PUNCT
gs-4062	1222	30	ada	ada	PROPN
gs-4062	1222	31	(	(	PUNCT
gs-4062	1222	32	adel	adel	PROPN
gs-4062	1222	33	)	)	PUNCT
gs-4062	1222	34	tadevosyan	tadevosyan	PROPN
gs-4062	1222	35	,	,	PUNCT
gs-4062	1222	36	and	and	CCONJ
gs-4062	1222	37	lali	lali	PROPN
gs-4062	1222	38	patsia	patsia	PROPN
gs-4062	1222	39	.	.	PUNCT
gs-4062	1223	1	2025	2025	NUM
gs-4062	1223	2	.	.	PUNCT
gs-4062	1224	1	“	"	PUNCT
gs-4062	1224	2	the	the	DET
gs-4062	1224	3	scientific	scientific	ADJ
gs-4062	1224	4	discussion	discussion	NOUN
gs-4062	1224	5	of	of	ADP
gs-4062	1224	6	key	key	ADJ
gs-4062	1224	7	issue	issue	NOUN
gs-4062	1224	8	aspects	aspect	NOUN
gs-4062	1224	9	of	of	ADP
gs-4062	1224	10	modern	modern	ADJ
gs-4062	1224	11	advancing	advance	VERB
gs-4062	1224	12	innovation	innovation	NOUN
gs-4062	1224	13	of	of	ADP
gs-4062	1224	14	learning	learning	NOUN
gs-4062	1224	15	and	and	CCONJ
gs-4062	1224	16	teaching	teaching	NOUN
gs-4062	1224	17	methods	method	NOUN
gs-4062	1224	18	and	and	CCONJ
gs-4062	1224	19	pedagogical	pedagogical	ADJ
gs-4062	1224	20	approaches	approach	NOUN
gs-4062	1224	21	in	in	ADP
gs-4062	1224	22	higher	high	ADJ
gs-4062	1224	23	education	education	NOUN
gs-4062	1224	24	institutions	institution	NOUN
gs-4062	1224	25	in	in	ADP
gs-4062	1224	26	medical	medical	ADJ
gs-4062	1224	27	educational	educational	ADJ
gs-4062	1224	28	study	study	NOUN
gs-4062	1224	29	programs	program	NOUN
gs-4062	1224	30	directions	direction	VERB
gs-4062	1224	31	globally	globally	ADV
gs-4062	1224	32	in	in	ADP
gs-4062	1224	33	general	general	ADJ
gs-4062	1224	34	”	"	PUNCT
gs-4062	1224	35	.	.	PUNCT
gs-4062	1225	1	scientific	scientific	ADJ
gs-4062	1225	2	journal	journal	NOUN
gs-4062	1225	3	„	„	PUNCT
gs-4062	1225	4	spectri	spectri	ADJ
gs-4062	1225	5	“	"	PUNCT
gs-4062	1225	6	10	10	NUM
gs-4062	1225	7	(	(	PUNCT
gs-4062	1225	8	2	2	NUM
gs-4062	1225	9	)	)	PUNCT
gs-4062	1225	10	.	.	PUNCT
gs-4062	1226	1	https://doi.org/10.52340/spectri.2024.10.01.12	https://doi.org/10.52340/spectri.2024.10.01.12	X
gs-4062	1226	2	.	.	X
gs-4062	1227	1	57	57	NUM
gs-4062	1227	2	.	.	X
gs-4062	1228	1	gorgaslidze	gorgaslidze	PROPN
gs-4062	1228	2	,	,	PUNCT
gs-4062	1228	3	nana	nana	PROPN
gs-4062	1228	4	,	,	PUNCT
gs-4062	1228	5	nodar	nodar	NOUN
gs-4062	1228	6	sulashvili	sulashvili	NOUN
gs-4062	1228	7	,	,	PUNCT
gs-4062	1228	8	luiza	luiza	PROPN
gs-4062	1228	9	gabunia	gabunia	PROPN
gs-4062	1228	10	,	,	PUNCT
gs-4062	1228	11	levan	levan	PROPN
gs-4062	1228	12	ratiani	ratiani	PROPN
gs-4062	1228	13	,	,	PUNCT
gs-4062	1228	14	and	and	CCONJ
gs-4062	1228	15	marina	marina	PROPN
gs-4062	1228	16	giorgobiani	giorgobiani	PROPN
gs-4062	1228	17	.	.	PUNCT
gs-4062	1229	1	2023	2023	NUM
gs-4062	1229	2	.	.	PUNCT
gs-4062	1230	1	“	"	PUNCT
gs-4062	1230	2	the	the	DET
gs-4062	1230	3	singularities	singularity	NOUN
gs-4062	1230	4	of	of	ADP
gs-4062	1230	5	temozolomide	temozolomide	NOUN
gs-4062	1230	6	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-4062	1230	7	effects	effect	NOUN
gs-4062	1230	8	in	in	ADP
gs-4062	1230	9	brain	brain	NOUN
gs-4062	1230	10	tumor	tumor	NOUN
gs-4062	1230	11	therapeutic	therapeutic	ADJ
gs-4062	1230	12	applications	application	NOUN
gs-4062	1230	13	”	"	PUNCT
gs-4062	1230	14	.	.	PUNCT
gs-4062	1231	1	experimental	experimental	ADJ
gs-4062	1231	2	and	and	CCONJ
gs-4062	1231	3	clinical	clinical	ADJ
gs-4062	1231	4	medicine	medicine	NOUN
gs-4062	1231	5	georgia	georgia	PROPN
gs-4062	1231	6	,	,	PUNCT
gs-4062	1231	7	no	no	INTJ
gs-4062	1231	8	.	.	NOUN
gs-4062	1231	9	4	4	NUM
gs-4062	1231	10	(	(	PUNCT
gs-4062	1231	11	november):62	november):62	NOUN
gs-4062	1231	12	-	-	PUNCT
gs-4062	1231	13	66	66	NUM
gs-4062	1231	14	.	.	PUNCT
gs-4062	1232	1	https://doi.org/10.52340/jecm.2023.04.16	https://doi.org/10.52340/jecm.2023.04.16	NUM
gs-4062	1232	2	.	.	PUNCT
gs-4062	1233	1	58	58	NUM
gs-4062	1233	2	.	.	PUNCT
gs-4062	1234	1	sulashvili	sulashvili	NOUN
gs-4062	1234	2	,	,	PUNCT
gs-4062	1234	3	nodar	nodar	ADV
gs-4062	1234	4	,	,	PUNCT
gs-4062	1234	5	margarita	margarita	PROPN
gs-4062	1234	6	beglaryan	beglaryan	PROPN
gs-4062	1234	7	,	,	PUNCT
gs-4062	1234	8	nana	nana	PROPN
gs-4062	1234	9	gorgaslidze	gorgaslidze	PROPN
gs-4062	1234	10	,	,	PUNCT
gs-4062	1234	11	seyran	seyran	PROPN
gs-4062	1234	12	kocharyan	kocharyan	PROPN
gs-4062	1234	13	,	,	PUNCT
gs-4062	1234	14	naira	naira	PROPN
gs-4062	1234	15	chichoyan	chichoyan	PROPN
gs-4062	1234	16	,	,	PUNCT
gs-4062	1234	17	luiza	luiza	PROPN
gs-4062	1234	18	gabunia	gabunia	PROPN
gs-4062	1234	19	,	,	PUNCT
gs-4062	1234	20	irine	irine	NOUN
gs-4062	1234	21	zarnadze	zarnadze	PROPN
gs-4062	1234	22	,	,	PUNCT
gs-4062	1234	23	et	et	PROPN
gs-4062	1234	24	al	al	PROPN
gs-4062	1234	25	.	.	PROPN
gs-4062	1234	26	2023	2023	NUM
gs-4062	1234	27	.	.	PUNCT
gs-4062	1235	1	“	"	PUNCT
gs-4062	1235	2	the	the	DET
gs-4062	1235	3	disclosure	disclosure	NOUN
gs-4062	1235	4	of	of	ADP
gs-4062	1235	5	features	feature	NOUN
gs-4062	1235	6	,	,	PUNCT
gs-4062	1235	7	characteristics	characteristic	NOUN
gs-4062	1235	8	,	,	PUNCT
gs-4062	1235	9	possibilities	possibility	NOUN
gs-4062	1235	10	and	and	CCONJ
gs-4062	1235	11	specialties	specialty	NOUN
gs-4062	1235	12	of	of	ADP
gs-4062	1235	13	clinical	clinical	ADJ
gs-4062	1235	14	pharmacists	pharmacist	NOUN
gs-4062	1235	15	as	as	ADP
gs-4062	1235	16	mediator	mediator	NOUN
gs-4062	1235	17	among	among	ADP
gs-4062	1235	18	doctors	doctor	NOUN
gs-4062	1235	19	and	and	CCONJ
gs-4062	1235	20	patients	patient	NOUN
gs-4062	1235	21	for	for	ADP
gs-4062	1235	22	enhancement	enhancement	NOUN
gs-4062	1235	23	public	public	ADJ
gs-4062	1235	24	health	health	NOUN
gs-4062	1235	25	sector	sector	NOUN
gs-4062	1235	26	in	in	ADP
gs-4062	1235	27	a	a	DET
gs-4062	1235	28	global	global	ADJ
gs-4062	1235	29	world	world	NOUN
gs-4062	1235	30	”	"	PUNCT
gs-4062	1235	31	.	.	PUNCT
gs-4062	1236	1	experimental	experimental	ADJ
gs-4062	1236	2	and	and	CCONJ
gs-4062	1236	3	clinical	clinical	ADJ
gs-4062	1236	4	medicine	medicine	NOUN
gs-4062	1236	5	georgia	georgia	PROPN
gs-4062	1236	6	,	,	PUNCT
gs-4062	1236	7	no	no	INTJ
gs-4062	1236	8	.	.	NOUN
gs-4062	1236	9	4	4	NUM
gs-4062	1236	10	(	(	PUNCT
gs-4062	1236	11	november):57	november):57	NOUN
gs-4062	1236	12	-	-	PUNCT
gs-4062	1236	13	62	62	NUM
gs-4062	1236	14	.	.	PUNCT
gs-4062	1237	1	https://doi.org/10.52340/jecm.2023.04.15	https://doi.org/10.52340/jecm.2023.04.15	PROPN
gs-4062	1237	2	.	.	PROPN
gs-4062	1237	3	59	59	NUM
gs-4062	1237	4	.	.	PUNCT
gs-4062	1238	1	kvizhinadze	kvizhinadze	PROPN
gs-4062	1238	2	,	,	PUNCT
gs-4062	1238	3	natia	natia	PROPN
gs-4062	1238	4	,	,	PUNCT
gs-4062	1238	5	nino	nino	PROPN
gs-4062	1238	6	intskirveli	intskirveli	PROPN
gs-4062	1238	7	,	,	PUNCT
gs-4062	1238	8	david	david	PROPN
gs-4062	1238	9	topuria	topuria	PROPN
gs-4062	1238	10	,	,	PUNCT
gs-4062	1238	11	nana	nana	PROPN
gs-4062	1238	12	dughashvili	dughashvili	NOUN
gs-4062	1238	13	,	,	PUNCT
gs-4062	1238	14	and	and	CCONJ
gs-4062	1238	15	nodar	nodar	NOUN
gs-4062	1238	16	sulashvili	sulashvili	NOUN
gs-4062	1238	17	.	.	PUNCT
gs-4062	1239	1	2023	2023	NUM
gs-4062	1239	2	.	.	PUNCT
gs-4062	1240	1	“	"	PUNCT
gs-4062	1240	2	gsp	gsp	NOUN
gs-4062	1240	3	and	and	CCONJ
gs-4062	1240	4	its	its	PRON
gs-4062	1240	5	features	feature	NOUN
gs-4062	1240	6	in	in	ADP
gs-4062	1240	7	medical	medical	ADJ
gs-4062	1240	8	and	and	CCONJ
gs-4062	1240	9	pharmaceutical	pharmaceutical	NOUN
gs-4062	1240	10	institutions	institution	NOUN
gs-4062	1240	11	”	"	PUNCT
gs-4062	1240	12	.	.	PUNCT
gs-4062	1241	1	experimental	experimental	ADJ
gs-4062	1241	2	and	and	CCONJ
gs-4062	1241	3	clinical	clinical	ADJ
gs-4062	1241	4	medicine	medicine	NOUN
gs-4062	1241	5	georgia	georgia	PROPN
gs-4062	1241	6	,	,	PUNCT
gs-4062	1241	7	no	no	INTJ
gs-4062	1241	8	.	.	NOUN
gs-4062	1241	9	4	4	NUM
gs-4062	1241	10	(	(	PUNCT
gs-4062	1241	11	november):17	november):17	NOUN
gs-4062	1241	12	-	-	PUNCT
gs-4062	1241	13	19	19	NUM
gs-4062	1241	14	.	.	PUNCT
gs-4062	1241	15	https://doi.org/10.52340/jecm.2023.04.03	https://doi.org/10.52340/jecm.2023.04.03	NUM
gs-4062	1241	16	.	.	X
gs-4062	1242	1	60	60	NUM
gs-4062	1242	2	.	.	PUNCT
gs-4062	1243	1	sulashvili	sulashvili	NOUN
gs-4062	1243	2	,	,	PUNCT
gs-4062	1243	3	nodar	nodar	PROPN
gs-4062	1243	4	,	,	PUNCT
gs-4062	1243	5	nana	nana	PROPN
gs-4062	1243	6	gorgaslidze	gorgaslidze	PROPN
gs-4062	1243	7	,	,	PUNCT
gs-4062	1243	8	margarita	margarita	PROPN
gs-4062	1243	9	beglaryan	beglaryan	PROPN
gs-4062	1243	10	,	,	PUNCT
gs-4062	1243	11	luiza	luiza	PROPN
gs-4062	1243	12	gabunia	gabunia	PROPN
gs-4062	1243	13	,	,	PUNCT
gs-4062	1243	14	naira	naira	PROPN
gs-4062	1243	15	chichoyan	chichoyan	PROPN
gs-4062	1243	16	,	,	PUNCT
gs-4062	1243	17	marina	marina	PROPN
gs-4062	1243	18	giorgobiani	giorgobiani	PROPN
gs-4062	1243	19	,	,	PUNCT
gs-4062	1243	20	irine	irine	NOUN
gs-4062	1243	21	zarnadze	zarnadze	NOUN
gs-4062	1243	22	,	,	PUNCT
gs-4062	1243	23	and	and	CCONJ
gs-4062	1243	24	shalva	shalva	PROPN
gs-4062	1243	25	(	(	PUNCT
gs-4062	1243	26	davit	davit	NOUN
gs-4062	1243	27	)	)	PUNCT
gs-4062	1243	28	zarnadze	zarnadze	NOUN
gs-4062	1243	29	.	.	PUNCT
gs-4062	1243	30	2022	2022	NUM
gs-4062	1243	31	.	.	PUNCT
gs-4062	1244	1	“	"	PUNCT
gs-4062	1244	2	the	the	DET
gs-4062	1244	3	scientific	scientific	ADJ
gs-4062	1244	4	talks	talk	NOUN
gs-4062	1244	5	of	of	ADP
gs-4062	1244	6	essential	essential	ADJ
gs-4062	1244	7	issue	issue	NOUN
gs-4062	1244	8	,	,	PUNCT
gs-4062	1244	9	invocation	invocation	NOUN
gs-4062	1244	10	,	,	PUNCT
gs-4062	1244	11	perspectives	perspective	NOUN
gs-4062	1244	12	,	,	PUNCT
gs-4062	1244	13	inclinations	inclination	NOUN
gs-4062	1244	14	and	and	CCONJ
gs-4062	1244	15	features	feature	NOUN
gs-4062	1244	16	of	of	ADP
gs-4062	1244	17	the	the	DET
gs-4062	1244	18	clinical	clinical	ADJ
gs-4062	1244	19	pharmacists	pharmacist	NOUN
gs-4062	1244	20	globally	globally	ADV
gs-4062	1244	21	”	"	PUNCT
gs-4062	1244	22	.	.	PUNCT
gs-4062	1245	1	experimental	experimental	ADJ
gs-4062	1245	2	and	and	CCONJ
gs-4062	1245	3	clinical	clinical	ADJ
gs-4062	1245	4	medicine	medicine	NOUN
gs-4062	1245	5	georgia	georgia	PROPN
gs-4062	1245	6	,	,	PUNCT
gs-4062	1245	7	no	no	INTJ
gs-4062	1245	8	.	.	NOUN
gs-4062	1245	9	7	7	NUM
gs-4062	1245	10	(	(	PUNCT
gs-4062	1245	11	october	october	PROPN
gs-4062	1245	12	)	)	PUNCT
gs-4062	1245	13	.	.	PUNCT
gs-4062	1246	1	https://doi.org/10.52340/jecm.2022.07.09	https://doi.org/10.52340/jecm.2022.07.09	PROPN
gs-4062	1246	2	.	.	PUNCT
gs-4062	1247	1	georgian	georgian	NOUN
gs-4062	1247	2	scientists/	scientists/	NUM
gs-4062	1247	3	.	.	PUNCT
gs-4062	1248	1	7	7	NUM
gs-4062	1248	2	n	n	PRON
gs-4062	1248	3	3	3	NUM
gs-4062	1248	4	,	,	PUNCT
gs-4062	1248	5	2025	2025	NUM
gs-4062	1248	6	568	568	NUM
gs-4062	1248	7	61	61	NUM
gs-4062	1248	8	.	.	PUNCT
gs-4062	1249	1	sulashvili	sulashvili	NOUN
gs-4062	1249	2	,	,	PUNCT
gs-4062	1249	3	nodar	nodar	INTJ
gs-4062	1249	4	,	,	PUNCT
gs-4062	1249	5	margarita	margarita	PROPN
gs-4062	1249	6	beglaryan	beglaryan	PROPN
gs-4062	1249	7	,	,	PUNCT
gs-4062	1249	8	nana	nana	PROPN
gs-4062	1249	9	gorgaslidze	gorgaslidze	PROPN
gs-4062	1249	10	,	,	PUNCT
gs-4062	1249	11	seyran	seyran	PROPN
gs-4062	1249	12	kocharyan	kocharyan	PROPN
gs-4062	1249	13	,	,	PUNCT
gs-4062	1249	14	naira	naira	PROPN
gs-4062	1249	15	chichoyan	chichoyan	PROPN
gs-4062	1249	16	,	,	PUNCT
gs-4062	1249	17	luiza	luiza	PROPN
gs-4062	1249	18	gabunia	gabunia	PROPN
gs-4062	1249	19	,	,	PUNCT
gs-4062	1249	20	natia	natia	PROPN
gs-4062	1249	21	kvizhinadze	kvizhinadze	PROPN
gs-4062	1249	22	,	,	PUNCT
gs-4062	1249	23	marina	marina	PROPN
gs-4062	1249	24	giorgobiani	giorgobiani	PROPN
gs-4062	1249	25	,	,	PUNCT
gs-4062	1249	26	irine	irine	NOUN
gs-4062	1249	27	zarnadze	zarnadze	NOUN
gs-4062	1249	28	,	,	PUNCT
gs-4062	1249	29	and	and	CCONJ
gs-4062	1249	30	shalva	shalva	PROPN
gs-4062	1249	31	(	(	PUNCT
gs-4062	1249	32	davit	davit	NOUN
gs-4062	1249	33	)	)	PUNCT
gs-4062	1249	34	zarnadze	zarnadze	NOUN
gs-4062	1249	35	.	.	PUNCT
gs-4062	1250	1	2022	2022	NUM
gs-4062	1250	2	.	.	PUNCT
gs-4062	1251	1	“	"	PUNCT
gs-4062	1251	2	the	the	DET
gs-4062	1251	3	scientific	scientific	ADJ
gs-4062	1251	4	discussion	discussion	NOUN
gs-4062	1251	5	of	of	ADP
gs-4062	1251	6	specificities	specificity	NOUN
gs-4062	1251	7	of	of	ADP
gs-4062	1251	8	pharmacist	pharmacist	NOUN
gs-4062	1251	9	occupational	occupational	ADJ
gs-4062	1251	10	and	and	CCONJ
gs-4062	1251	11	higher	high	ADJ
gs-4062	1251	12	medical	medical	ADJ
gs-4062	1251	13	-	-	PUNCT
gs-4062	1251	14	pharmaceutical	pharmaceutical	ADJ
gs-4062	1251	15	educational	educational	ADJ
gs-4062	1251	16	manifestation	manifestation	NOUN
gs-4062	1251	17	outlooks	outlook	NOUN
gs-4062	1251	18	in	in	ADP
gs-4062	1251	19	georgia	georgia	PROPN
gs-4062	1251	20	”	"	PUNCT
gs-4062	1251	21	.	.	PUNCT
gs-4062	1252	1	experimental	experimental	ADJ
gs-4062	1252	2	and	and	CCONJ
gs-4062	1252	3	clinical	clinical	ADJ
gs-4062	1252	4	medicine	medicine	NOUN
gs-4062	1252	5	georgia	georgia	PROPN
gs-4062	1252	6	,	,	PUNCT
gs-4062	1252	7	no	no	INTJ
gs-4062	1252	8	.	.	NOUN
gs-4062	1252	9	7	7	NUM
gs-4062	1252	10	(	(	PUNCT
gs-4062	1252	11	october	october	PROPN
gs-4062	1252	12	)	)	PUNCT
gs-4062	1252	13	.	.	PUNCT
gs-4062	1253	1	https://doi.org/10.52340/jecm.2022.07.08	https://doi.org/10.52340/jecm.2022.07.08	NUM
gs-4062	1253	2	.	.	PUNCT
gs-4062	1254	1	62	62	NUM
gs-4062	1254	2	.	.	PUNCT
gs-4062	1255	1	gorgaslidze	gorgaslidze	PROPN
gs-4062	1255	2	,	,	PUNCT
gs-4062	1255	3	nana	nana	PROPN
gs-4062	1255	4	,	,	PUNCT
gs-4062	1255	5	shafiga	shafiga	PROPN
gs-4062	1255	6	topchiyeva	topchiyeva	PROPN
gs-4062	1255	7	,	,	PUNCT
gs-4062	1255	8	marina	marina	NOUN
gs-4062	1255	9	giorgobiani	giorgobiani	PROPN
gs-4062	1255	10	,	,	PUNCT
gs-4062	1255	11	and	and	CCONJ
gs-4062	1255	12	nodar	nodar	NOUN
gs-4062	1255	13	sulashvili	sulashvili	NOUN
gs-4062	1255	14	.	.	PUNCT
gs-4062	1256	1	2022	2022	NUM
gs-4062	1256	2	.	.	PUNCT
gs-4062	1257	1	“	"	PUNCT
gs-4062	1257	2	the	the	DET
gs-4062	1257	3	impact	impact	NOUN
gs-4062	1257	4	of	of	ADP
gs-4062	1257	5	pharmaceutical	pharmaceutical	ADJ
gs-4062	1257	6	marketing	marketing	NOUN
gs-4062	1257	7	on	on	ADP
gs-4062	1257	8	the	the	DET
gs-4062	1257	9	society	society	NOUN
gs-4062	1257	10	and	and	CCONJ
gs-4062	1257	11	individual	individual	ADJ
gs-4062	1257	12	patient	patient	NOUN
gs-4062	1257	13	and	and	CCONJ
gs-4062	1257	14	its	its	PRON
gs-4062	1257	15	specification	specification	NOUN
gs-4062	1257	16	of	of	ADP
gs-4062	1257	17	handling	handling	NOUN
gs-4062	1257	18	”	"	PUNCT
gs-4062	1257	19	.	.	PUNCT
gs-4062	1258	1	experimental	experimental	ADJ
gs-4062	1258	2	and	and	CCONJ
gs-4062	1258	3	clinical	clinical	ADJ
gs-4062	1258	4	medicine	medicine	NOUN
gs-4062	1258	5	georgia	georgia	PROPN
gs-4062	1258	6	,	,	PUNCT
gs-4062	1258	7	no	no	INTJ
gs-4062	1258	8	.	.	NOUN
gs-4062	1258	9	7	7	NUM
gs-4062	1258	10	(	(	PUNCT
gs-4062	1258	11	october	october	PROPN
gs-4062	1258	12	)	)	PUNCT
gs-4062	1258	13	.	.	PUNCT
gs-4062	1259	1	https://doi.org/10.52340/jecm.2022.07.07	https://doi.org/10.52340/jecm.2022.07.07	X
gs-4062	1259	2	.	.	PUNCT
gs-4062	1260	1	63	63	NUM
gs-4062	1260	2	.	.	PUNCT
gs-4062	1261	1	gorgaslidze	gorgaslidze	PROPN
gs-4062	1261	2	,	,	PUNCT
gs-4062	1261	3	nana	nana	PROPN
gs-4062	1261	4	,	,	PUNCT
gs-4062	1261	5	and	and	CCONJ
gs-4062	1261	6	nodar	nodar	NOUN
gs-4062	1261	7	sulashvili	sulashvili	NOUN
gs-4062	1261	8	.	.	PUNCT
gs-4062	1262	1	2022	2022	NUM
gs-4062	1262	2	.	.	PUNCT
gs-4062	1263	1	“	"	PUNCT
gs-4062	1263	2	the	the	DET
gs-4062	1263	3	features	feature	NOUN
gs-4062	1263	4	of	of	ADP
gs-4062	1263	5	the	the	DET
gs-4062	1263	6	pharmaceutical	pharmaceutical	ADJ
gs-4062	1263	7	market	market	NOUN
gs-4062	1263	8	and	and	CCONJ
gs-4062	1263	9	its	its	PRON
gs-4062	1263	10	outlooks	outlook	NOUN
gs-4062	1263	11	in	in	ADP
gs-4062	1263	12	georgia	georgia	PROPN
gs-4062	1263	13	”	"	PUNCT
gs-4062	1263	14	.	.	PUNCT
gs-4062	1264	1	experimental	experimental	ADJ
gs-4062	1264	2	and	and	CCONJ
gs-4062	1264	3	clinical	clinical	ADJ
gs-4062	1264	4	medicine	medicine	NOUN
gs-4062	1264	5	georgia	georgia	PROPN
gs-4062	1264	6	,	,	PUNCT
gs-4062	1264	7	no	no	INTJ
gs-4062	1264	8	.	.	NOUN
gs-4062	1264	9	7	7	NUM
gs-4062	1264	10	(	(	PUNCT
gs-4062	1264	11	october	october	PROPN
gs-4062	1264	12	)	)	PUNCT
gs-4062	1264	13	.	.	PUNCT
gs-4062	1265	1	https://doi.org/10.52340/jecm.2022.07.06	https://doi.org/10.52340/jecm.2022.07.06	PROPN
gs-4062	1265	2	.	.	PUNCT
gs-4062	1266	1	64	64	NUM
gs-4062	1266	2	.	.	PUNCT
gs-4062	1267	1	nana	nana	PROPN
gs-4062	1267	2	gorgaslidze	gorgaslidze	PROPN
gs-4062	1267	3	,	,	PUNCT
gs-4062	1267	4	nodar	nodar	NOUN
gs-4062	1267	5	sulashvili	sulashvili	NOUN
gs-4062	1267	6	,	,	PUNCT
gs-4062	1267	7	marina	marina	NOUN
gs-4062	1267	8	giorgobiani	giorgobiani	PROPN
gs-4062	1267	9	,	,	PUNCT
gs-4062	1267	10	tea	tea	NOUN
gs-4062	1267	11	zarkua	zarkua	NOUN
gs-4062	1267	12	,	,	PUNCT
gs-4062	1267	13	nana	nana	PROPN
gs-4062	1267	14	dugashvili	dugashvili	PROPN
gs-4062	1267	15	.	.	PUNCT
gs-4062	1268	1	the	the	DET
gs-4062	1268	2	features	feature	NOUN
gs-4062	1268	3	of	of	ADP
gs-4062	1268	4	inspection	inspection	NOUN
gs-4062	1268	5	and	and	CCONJ
gs-4062	1268	6	monitoring	monitoring	NOUN
gs-4062	1268	7	framework	framework	NOUN
gs-4062	1268	8	for	for	ADP
gs-4062	1268	9	professional	professional	ADJ
gs-4062	1268	10	safety	safety	NOUN
gs-4062	1268	11	,	,	PUNCT
gs-4062	1268	12	sanitary	sanitary	NOUN
gs-4062	1268	13	,	,	PUNCT
gs-4062	1268	14	bioecological	bioecological	ADJ
gs-4062	1268	15	,	,	PUNCT
gs-4062	1268	16	preventive	preventive	ADJ
gs-4062	1268	17	and	and	CCONJ
gs-4062	1268	18	hygienic	hygienic	ADJ
gs-4062	1268	19	novel	novel	ADJ
gs-4062	1268	20	requirement	requirement	NOUN
gs-4062	1268	21	issues	issue	NOUN
gs-4062	1268	22	of	of	ADP
gs-4062	1268	23	pharmaceutical	pharmaceutical	ADJ
gs-4062	1268	24	organizations	organization	NOUN
gs-4062	1268	25	in	in	ADP
gs-4062	1268	26	the	the	DET
gs-4062	1268	27	context	context	NOUN
gs-4062	1268	28	of	of	ADP
gs-4062	1268	29	the	the	DET
gs-4062	1268	30	covid-19	covid-19	PROPN
gs-4062	1268	31	pandemic	pandemic	NOUN
gs-4062	1268	32	in	in	ADP
gs-4062	1268	33	georgia	georgia	PROPN
gs-4062	1268	34	.	.	PUNCT
gs-4062	1269	1	jecmg	jecmg	PROPN
gs-4062	1270	1	[	[	X
gs-4062	1270	2	internet	internet	NOUN
gs-4062	1270	3	]	]	PUNCT
gs-4062	1270	4	.	.	PUNCT
gs-4062	1271	1	2021	2021	NUM
gs-4062	1271	2	oct	oct	PROPN
gs-4062	1271	3	.	.	PROPN
gs-4062	1271	4	19	19	NUM
gs-4062	1272	1	[	[	X
gs-4062	1272	2	cited	cite	VERB
gs-4062	1272	3	2025	2025	NUM
gs-4062	1272	4	jul	jul	PROPN
gs-4062	1272	5	.	.	PUNCT
gs-4062	1272	6	12];(5	12];(5	PROPN
gs-4062	1272	7	-	-	PUNCT
gs-4062	1272	8	6):42	6):42	PROPN
gs-4062	1272	9	-	-	PUNCT
gs-4062	1272	10	6	6	NUM
gs-4062	1272	11	.	.	PUNCT
gs-4062	1272	12	available	available	ADJ
gs-4062	1272	13	from	from	ADP
gs-4062	1272	14	:	:	PUNCT
gs-4062	1272	15	https://journals.4science.ge/index.php/jecm/article/view/576	https://journals.4science.ge/index.php/jecm/article/view/576	PROPN
gs-4062	1272	16	.	.	PUNCT
gs-4062	1273	1	65	65	NUM
gs-4062	1273	2	.	.	PUNCT
gs-4062	1273	3	sulashvili	sulashvili	NOUN
gs-4062	1273	4	,	,	PUNCT
gs-4062	1273	5	nodar	nodar	PROPN
gs-4062	1273	6	,	,	PUNCT
gs-4062	1273	7	nana	nana	PROPN
gs-4062	1273	8	gorgaslidze	gorgaslidze	PROPN
gs-4062	1273	9	,	,	PUNCT
gs-4062	1273	10	margarita	margarita	PROPN
gs-4062	1273	11	beglaryan	beglaryan	PROPN
gs-4062	1273	12	,	,	PUNCT
gs-4062	1273	13	luiza	luiza	PROPN
gs-4062	1273	14	gabunia	gabunia	PROPN
gs-4062	1273	15	,	,	PUNCT
gs-4062	1273	16	natia	natia	PROPN
gs-4062	1273	17	kvizhinadze	kvizhinadze	PROPN
gs-4062	1273	18	,	,	PUNCT
gs-4062	1273	19	tea	tea	NOUN
gs-4062	1273	20	zarkua	zarkua	NOUN
gs-4062	1273	21	,	,	PUNCT
gs-4062	1273	22	marina	marina	NOUN
gs-4062	1273	23	giorgobiani	giorgobiani	PROPN
gs-4062	1273	24	,	,	PUNCT
gs-4062	1273	25	nana	nana	PROPN
gs-4062	1273	26	peikrishvili	peikrishvili	NOUN
gs-4062	1273	27	,	,	PUNCT
gs-4062	1273	28	and	and	CCONJ
gs-4062	1273	29	marika	marika	PROPN
gs-4062	1273	30	sulashvili	sulashvili	PROPN
gs-4062	1273	31	.	.	PUNCT
gs-4062	1274	1	2024	2024	NUM
gs-4062	1274	2	.	.	PUNCT
gs-4062	1275	1	“	"	PUNCT
gs-4062	1275	2	the	the	DET
gs-4062	1275	3	manifestation	manifestation	NOUN
gs-4062	1275	4	of	of	ADP
gs-4062	1275	5	characteristics	characteristic	NOUN
gs-4062	1275	6	,	,	PUNCT
gs-4062	1275	7	opportunities	opportunity	NOUN
gs-4062	1275	8	and	and	CCONJ
gs-4062	1275	9	challenges	challenge	NOUN
gs-4062	1275	10	of	of	ADP
gs-4062	1275	11	electronic	electronic	ADJ
gs-4062	1275	12	systems	system	NOUN
gs-4062	1275	13	and	and	CCONJ
gs-4062	1275	14	digital	digital	ADJ
gs-4062	1275	15	intelligence	intelligence	NOUN
gs-4062	1275	16	using	use	VERB
gs-4062	1275	17	in	in	ADP
gs-4062	1275	18	pharmaceutical	pharmaceutical	ADJ
gs-4062	1275	19	services	service	NOUN
gs-4062	1275	20	”	"	PUNCT
gs-4062	1275	21	.	.	PUNCT
gs-4062	1276	1	experimental	experimental	ADJ
gs-4062	1276	2	and	and	CCONJ
gs-4062	1276	3	clinical	clinical	ADJ
gs-4062	1276	4	medicine	medicine	NOUN
gs-4062	1276	5	georgia	georgia	PROPN
gs-4062	1276	6	,	,	PUNCT
gs-4062	1276	7	no	no	INTJ
gs-4062	1276	8	.	.	NOUN
gs-4062	1276	9	4	4	NUM
gs-4062	1276	10	(	(	PUNCT
gs-4062	1276	11	september):122	september):122	PROPN
gs-4062	1276	12	-	-	PUNCT
gs-4062	1276	13	25	25	NUM
gs-4062	1276	14	.	.	PUNCT
gs-4062	1277	1	https://doi.org/10.52340/jecm.2024.04.33	https://doi.org/10.52340/jecm.2024.04.33	PROPN
gs-4062	1277	2	.	.	PROPN
gs-4062	1278	1	66	66	NUM
gs-4062	1278	2	.	.	PUNCT
gs-4062	1279	1	sulashvili	sulashvili	PROPN
gs-4062	1279	2	n	n	CCONJ
gs-4062	1279	3	,	,	PUNCT
gs-4062	1279	4	davitashvili	davitashvili	PROPN
gs-4062	1279	5	m	m	PROPN
gs-4062	1279	6	,	,	PUNCT
gs-4062	1279	7	gorgaslidze	gorgaslidze	ADJ
gs-4062	1279	8	n	n	CCONJ
gs-4062	1279	9	,	,	PUNCT
gs-4062	1279	10	gabunia	gabunia	NOUN
gs-4062	1279	11	l	l	NOUN
gs-4062	1279	12	,	,	PUNCT
gs-4062	1279	13	beglaryan	beglaryan	PROPN
gs-4062	1279	14	m	m	PROPN
gs-4062	1279	15	,	,	PUNCT
gs-4062	1279	16	alavidze	alavidze	PROPN
gs-4062	1279	17	n	n	CCONJ
gs-4062	1279	18	,	,	PUNCT
gs-4062	1279	19	et	et	PROPN
gs-4062	1279	20	al	al	PROPN
gs-4062	1279	21	.	.	PUNCT
gs-4062	1280	1	the	the	DET
gs-4062	1280	2	scientific	scientific	ADJ
gs-4062	1280	3	discussion	discussion	NOUN
gs-4062	1280	4	of	of	ADP
gs-4062	1280	5	some	some	DET
gs-4062	1280	6	issues	issue	NOUN
gs-4062	1280	7	of	of	ADP
gs-4062	1280	8	features	feature	NOUN
gs-4062	1280	9	and	and	CCONJ
gs-4062	1280	10	challenges	challenge	NOUN
gs-4062	1280	11	of	of	ADP
gs-4062	1280	12	using	use	VERB
gs-4062	1280	13	of	of	ADP
gs-4062	1280	14	car	car	NOUN
gs-4062	1280	15	-	-	PUNCT
gs-4062	1280	16	t	t	NOUN
gs-4062	1280	17	cells	cell	NOUN
gs-4062	1280	18	in	in	ADP
gs-4062	1280	19	immunotherapy	immunotherapy	NOUN
gs-4062	1280	20	.	.	PUNCT
gs-4062	1281	1	gs	gs	X
gs-4062	1282	1	[	[	X
gs-4062	1282	2	internet	internet	NOUN
gs-4062	1282	3	]	]	PUNCT
gs-4062	1282	4	.	.	PUNCT
gs-4062	1283	1	2024	2024	NUM
gs-4062	1283	2	nov	nov	PROPN
gs-4062	1283	3	.	.	PROPN
gs-4062	1283	4	26	26	NUM
gs-4062	1283	5	[	[	X
gs-4062	1283	6	cited	cite	VERB
gs-4062	1283	7	2025	2025	NUM
gs-4062	1283	8	jul	jul	PROPN
gs-4062	1283	9	.	.	PUNCT
gs-4062	1283	10	12];6(4):263	12];6(4):263	NUM
gs-4062	1283	11	-	-	SYM
gs-4062	1283	12	90	90	NUM
gs-4062	1283	13	.	.	PUNCT
gs-4062	1284	1	available	available	ADJ
gs-4062	1284	2	from	from	ADP
gs-4062	1284	3	:	:	PUNCT
gs-4062	1284	4	https://journals.4science.ge/index.php/gs/article/view/3214	https://journals.4science.ge/index.php/gs/article/view/3214	X
gs-4062	1284	5	.	.	PUNCT
gs-4062	1285	1	67	67	NUM
gs-4062	1285	2	.	.	PUNCT
gs-4062	1286	1	sulashvili	sulashvili	PROPN
gs-4062	1286	2	n	n	CCONJ
gs-4062	1286	3	,	,	PUNCT
gs-4062	1286	4	nimangre	nimangre	PROPN
gs-4062	1286	5	rr	rr	PROPN
gs-4062	1286	6	.	.	PUNCT
gs-4062	1287	1	manifestation	manifestation	NOUN
gs-4062	1287	2	of	of	ADP
gs-4062	1287	3	some	some	DET
gs-4062	1287	4	aspects	aspect	NOUN
gs-4062	1287	5	of	of	ADP
gs-4062	1287	6	cardiovascular	cardiovascular	ADJ
gs-4062	1287	7	diseases	disease	NOUN
gs-4062	1287	8	,	,	PUNCT
gs-4062	1287	9	implications	implication	NOUN
gs-4062	1287	10	,	,	PUNCT
gs-4062	1287	11	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-4062	1287	12	strategies	strategy	NOUN
gs-4062	1287	13	,	,	PUNCT
gs-4062	1287	14	effects	effect	NOUN
gs-4062	1287	15	,	,	PUNCT
gs-4062	1287	16	impacts	impact	NOUN
gs-4062	1287	17	and	and	CCONJ
gs-4062	1287	18	potential	potential	ADJ
gs-4062	1287	19	hazards	hazard	NOUN
gs-4062	1287	20	in	in	ADP
gs-4062	1287	21	general	general	ADJ
gs-4062	1287	22	.	.	PUNCT
gs-4062	1288	1	jr	jr	PROPN
gs-4062	1289	1	[	[	X
gs-4062	1289	2	internet	internet	NOUN
gs-4062	1289	3	]	]	PUNCT
gs-4062	1289	4	.	.	PUNCT
gs-4062	1290	1	2025	2025	NUM
gs-4062	1290	2	feb	feb	X
gs-4062	1290	3	.	.	PROPN
gs-4062	1290	4	7	7	NUM
gs-4062	1290	5	[	[	X
gs-4062	1290	6	cited	cite	VERB
gs-4062	1290	7	2025	2025	NUM
gs-4062	1290	8	jul	jul	PROPN
gs-4062	1290	9	.	.	PUNCT
gs-4062	1291	1	12];3(1):1	12];3(1):1	NUM
gs-4062	1291	2	-	-	SYM
gs-4062	1291	3	27	27	NUM
gs-4062	1291	4	.	.	PUNCT
gs-4062	1292	1	available	available	ADJ
gs-4062	1292	2	from	from	ADP
gs-4062	1292	3	:	:	PUNCT
gs-4062	1292	4	https://journals.4science.ge/index.php/jr/article/view/3393	https://journals.4science.ge/index.php/jr/article/view/3393	PROPN
gs-4062	1292	5	.	.	PUNCT
gs-4062	1293	1	68	68	NUM
gs-4062	1293	2	.	.	PUNCT
gs-4062	1294	1	sax	sax	PROPN
gs-4062	1294	2	pe	pe	PROPN
gs-4062	1294	3	,	,	PUNCT
gs-4062	1294	4	wohl	wohl	PROPN
gs-4062	1294	5	d	d	PROPN
gs-4062	1294	6	,	,	PUNCT
gs-4062	1294	7	yin	yin	PROPN
gs-4062	1294	8	mt	mt	PROPN
gs-4062	1294	9	,	,	PUNCT
gs-4062	1294	10	post	post	NOUN
gs-4062	1294	11	f	f	PROPN
gs-4062	1294	12	,	,	PUNCT
gs-4062	1294	13	dejesus	dejesus	PROPN
gs-4062	1294	14	e	e	PROPN
gs-4062	1294	15	,	,	PUNCT
gs-4062	1294	16	saag	saag	PROPN
gs-4062	1294	17	m	m	PROPN
gs-4062	1294	18	,	,	PUNCT
gs-4062	1294	19	et	et	PROPN
gs-4062	1294	20	al	al	PROPN
gs-4062	1294	21	.	.	PROPN
gs-4062	1295	1	tenofovir	tenofovir	PROPN
gs-4062	1295	2	alafenamide	alafenamide	PROPN
gs-4062	1295	3	versus	versus	ADP
gs-4062	1295	4	tenofovir	tenofovir	PROPN
gs-4062	1295	5	disoproxil	disoproxil	VERB
gs-4062	1295	6	fumarate	fumarate	NOUN
gs-4062	1295	7	,	,	PUNCT
gs-4062	1295	8	coformulated	coformulate	VERB
gs-4062	1295	9	with	with	ADP
gs-4062	1295	10	elvitegravir	elvitegravir	PROPN
gs-4062	1295	11	,	,	PUNCT
gs-4062	1295	12	cobicistat	cobicistat	NOUN
gs-4062	1295	13	,	,	PUNCT
gs-4062	1295	14	and	and	CCONJ
gs-4062	1295	15	emtricitabine	emtricitabine	PROPN
gs-4062	1295	16	,	,	PUNCT
gs-4062	1295	17	for	for	ADP
gs-4062	1295	18	initial	initial	ADJ
gs-4062	1295	19	treatment	treatment	NOUN
gs-4062	1295	20	of	of	ADP
gs-4062	1295	21	hiv-1	hiv-1	ADJ
gs-4062	1295	22	infection	infection	NOUN
gs-4062	1295	23	:	:	PUNCT
gs-4062	1295	24	two	two	NUM
gs-4062	1295	25	randomised	randomised	ADJ
gs-4062	1295	26	,	,	PUNCT
gs-4062	1295	27	double	double	ADJ
gs-4062	1295	28	-	-	PUNCT
gs-4062	1295	29	blind	blind	ADJ
gs-4062	1295	30	,	,	PUNCT
gs-4062	1295	31	phase	phase	NOUN
gs-4062	1295	32	3	3	NUM
gs-4062	1295	33	,	,	PUNCT
gs-4062	1295	34	non	non	ADJ
gs-4062	1295	35	-	-	ADJ
gs-4062	1295	36	inferiority	inferiority	ADJ
gs-4062	1295	37	trials	trial	NOUN
gs-4062	1295	38	.	.	PUNCT
gs-4062	1296	1	lancet	lancet	VERB
gs-4062	1296	2	.	.	PUNCT
gs-4062	1297	1	2015	2015	NUM
gs-4062	1297	2	apr	apr	NOUN
gs-4062	1297	3	11;385(9977):2606	11;385(9977):2606	NUM
gs-4062	1297	4	-	-	SYM
gs-4062	1297	5	15	15	NUM
gs-4062	1297	6	.	.	PUNCT
gs-4062	1297	7	69	69	NUM
gs-4062	1297	8	.	.	PUNCT
gs-4062	1298	1	taramasso	taramasso	PROPN
gs-4062	1298	2	l	l	NOUN
gs-4062	1298	3	,	,	PUNCT
gs-4062	1298	4	tatarelli	tatarelli	PROPN
gs-4062	1298	5	p	p	NOUN
gs-4062	1298	6	,	,	PUNCT
gs-4062	1298	7	di	di	PROPN
gs-4062	1298	8	biagio	biagio	PROPN
gs-4062	1298	9	a.	a.	PROPN
gs-4062	1298	10	drug	drug	PROPN
gs-4062	1298	11	-	-	PUNCT
gs-4062	1298	12	drug	drug	NOUN
gs-4062	1298	13	interactions	interaction	NOUN
gs-4062	1298	14	between	between	ADP
gs-4062	1298	15	antiretroviral	antiretroviral	ADJ
gs-4062	1298	16	and	and	CCONJ
gs-4062	1298	17	nonantiretroviral	nonantiretroviral	ADJ
gs-4062	1298	18	agents	agent	NOUN
gs-4062	1298	19	.	.	PUNCT
gs-4062	1299	1	curr	curr	PROPN
gs-4062	1299	2	opin	opin	PROPN
gs-4062	1299	3	hiv	hiv	PROPN
gs-4062	1299	4	aids	aids	PROPN
gs-4062	1299	5	.	.	PUNCT
gs-4062	1300	1	2017	2017	NUM
gs-4062	1300	2	sep;12(5):441	sep;12(5):441	NOUN
gs-4062	1300	3	-	-	PUNCT
gs-4062	1300	4	447	447	NUM
gs-4062	1300	5	.	.	PUNCT
gs-4062	1301	1	georgian	georgian	NOUN
gs-4062	1301	2	scientists/	scientists/	NUM
gs-4062	1301	3	.	.	PUNCT
gs-4062	1302	1	7	7	NUM
gs-4062	1302	2	n	n	PRON
gs-4062	1302	3	3	3	NUM
gs-4062	1302	4	,	,	PUNCT
gs-4062	1302	5	2025	2025	NUM
gs-4062	1302	6	569	569	NUM
gs-4062	1302	7	70	70	NUM
gs-4062	1302	8	.	.	PUNCT
gs-4062	1303	1	german	german	ADJ
gs-4062	1303	2	p	p	X
gs-4062	1303	3	,	,	PUNCT
gs-4062	1303	4	warren	warren	PROPN
gs-4062	1303	5	d	d	PROPN
gs-4062	1303	6	,	,	PUNCT
gs-4062	1303	7	west	west	PROPN
gs-4062	1303	8	s	s	PROPN
gs-4062	1303	9	,	,	PUNCT
gs-4062	1303	10	hui	hui	PROPN
gs-4062	1303	11	j	j	PROPN
gs-4062	1303	12	,	,	PUNCT
gs-4062	1303	13	kearney	kearney	PROPN
gs-4062	1303	14	bp	bp	PROPN
gs-4062	1303	15	.	.	PUNCT
gs-4062	1304	1	pharmacokinetics	pharmacokinetic	NOUN
gs-4062	1304	2	and	and	CCONJ
gs-4062	1304	3	bioavailability	bioavailability	NOUN
gs-4062	1304	4	of	of	ADP
gs-4062	1304	5	an	an	DET
gs-4062	1304	6	integrase	integrase	NOUN
gs-4062	1304	7	and	and	CCONJ
gs-4062	1304	8	novel	novel	ADJ
gs-4062	1304	9	pharmacoenhancer	pharmacoenhancer	ADV
gs-4062	1304	10	-	-	PUNCT
gs-4062	1304	11	containing	contain	VERB
gs-4062	1304	12	single	single	ADJ
gs-4062	1304	13	-	-	PUNCT
gs-4062	1304	14	tablet	tablet	NOUN
gs-4062	1304	15	fixed	fix	VERB
gs-4062	1304	16	-	-	PUNCT
gs-4062	1304	17	dose	dose	NOUN
gs-4062	1304	18	combination	combination	NOUN
gs-4062	1304	19	regimen	regiman	NOUN
gs-4062	1304	20	for	for	ADP
gs-4062	1304	21	the	the	DET
gs-4062	1304	22	treatment	treatment	NOUN
gs-4062	1304	23	of	of	ADP
gs-4062	1304	24	hiv	hiv	PROPN
gs-4062	1304	25	.	.	PUNCT
gs-4062	1305	1	j	j	PROPN
gs-4062	1305	2	acquir	acquir	PROPN
gs-4062	1305	3	immune	immune	VERB
gs-4062	1305	4	defic	defic	ADJ
gs-4062	1305	5	syndr	syndr	NOUN
gs-4062	1305	6	.	.	PUNCT
gs-4062	1306	1	2010	2010	NUM
gs-4062	1306	2	dec;55(3):323	dec;55(3):323	NOUN
gs-4062	1306	3	-	-	PUNCT
gs-4062	1306	4	9	9	NUM
gs-4062	1306	5	.	.	NUM
gs-4062	1306	6	71	71	NUM
gs-4062	1306	7	.	.	PUNCT
gs-4062	1307	1	custodio	custodio	PROPN
gs-4062	1307	2	jm	jm	PROPN
gs-4062	1307	3	,	,	PUNCT
gs-4062	1307	4	fordyce	fordyce	PROPN
gs-4062	1307	5	m	m	PROPN
gs-4062	1307	6	,	,	PUNCT
gs-4062	1307	7	garner	garner	PROPN
gs-4062	1307	8	w	w	PROPN
gs-4062	1307	9	,	,	PUNCT
gs-4062	1307	10	vimal	vimal	PROPN
gs-4062	1307	11	m	m	PROPN
gs-4062	1307	12	,	,	PUNCT
gs-4062	1307	13	ling	ling	PROPN
gs-4062	1307	14	khj	khj	PROPN
gs-4062	1307	15	,	,	PUNCT
gs-4062	1307	16	sager	sager	PROPN
gs-4062	1307	17	j	j	PROPN
gs-4062	1307	18	,	,	PUNCT
gs-4062	1307	19	et	et	PROPN
gs-4062	1307	20	al	al	PROPN
gs-4062	1307	21	.	.	PUNCT
gs-4062	1307	22	pharmacokinetics	pharmacokinetic	NOUN
gs-4062	1307	23	and	and	CCONJ
gs-4062	1307	24	safety	safety	NOUN
gs-4062	1307	25	of	of	ADP
gs-4062	1307	26	tenofovir	tenofovir	ADJ
gs-4062	1307	27	alafenamide	alafenamide	PROPN
gs-4062	1307	28	in	in	ADP
gs-4062	1307	29	hiv	hiv	PROPN
gs-4062	1307	30	-	-	PUNCT
gs-4062	1307	31	uninfected	uninfected	ADJ
gs-4062	1307	32	subjects	subject	NOUN
gs-4062	1307	33	with	with	ADP
gs-4062	1307	34	severe	severe	ADJ
gs-4062	1307	35	renal	renal	ADJ
gs-4062	1307	36	impairment	impairment	NOUN
gs-4062	1307	37	.	.	PUNCT
gs-4062	1308	1	antimicrob	antimicrob	PROPN
gs-4062	1308	2	agents	agents	PROPN
gs-4062	1308	3	chemother	chemother	PROPN
gs-4062	1308	4	.	.	PUNCT
gs-4062	1309	1	2016	2016	NUM
gs-4062	1309	2	sep	sep	NOUN
gs-4062	1309	3	23;60(10):6095	23;60(10):6095	PROPN
gs-4062	1309	4	-	-	SYM
gs-4062	1309	5	101	101	NUM
gs-4062	1309	6	.	.	PUNCT
gs-4062	1309	7	72	72	NUM
gs-4062	1309	8	.	.	X
gs-4062	1310	1	scarsi	scarsi	PROPN
gs-4062	1310	2	kk	kk	PROPN
gs-4062	1310	3	,	,	PUNCT
gs-4062	1310	4	havens	haven	NOUN
gs-4062	1310	5	jp	jp	NOUN
gs-4062	1310	6	,	,	PUNCT
gs-4062	1310	7	podany	podany	NOUN
gs-4062	1310	8	at	at	ADP
gs-4062	1310	9	,	,	PUNCT
gs-4062	1310	10	avedissian	avedissian	ADJ
gs-4062	1310	11	sn	sn	PROPN
gs-4062	1310	12	,	,	PUNCT
gs-4062	1310	13	fletcher	fletcher	PROPN
gs-4062	1310	14	cv	cv	PROPN
gs-4062	1310	15	.	.	PROPN
gs-4062	1310	16	hiv-1	hiv-1	X
gs-4062	1310	17	integrase	integrase	VERB
gs-4062	1310	18	inhibitors	inhibitor	NOUN
gs-4062	1310	19	:	:	PUNCT
gs-4062	1310	20	a	a	DET
gs-4062	1310	21	comparative	comparative	ADJ
gs-4062	1310	22	review	review	NOUN
gs-4062	1310	23	of	of	ADP
gs-4062	1310	24	efficacy	efficacy	NOUN
gs-4062	1310	25	and	and	CCONJ
gs-4062	1310	26	safety	safety	NOUN
gs-4062	1310	27	.	.	PUNCT
gs-4062	1311	1	drugs	drug	NOUN
gs-4062	1311	2	.	.	PUNCT
gs-4062	1312	1	2020	2020	NUM
gs-4062	1312	2	oct;80(16):1649	oct;80(16):1649	NOUN
gs-4062	1312	3	-	-	SYM
gs-4062	1312	4	1676	1676	NUM
gs-4062	1312	5	.	.	PUNCT
gs-4062	1313	1	73	73	NUM
gs-4062	1313	2	.	.	PUNCT
gs-4062	1314	1	arts	arts	PROPN
gs-4062	1314	2	ej	ej	PROPN
gs-4062	1314	3	,	,	PUNCT
gs-4062	1314	4	hazuda	hazuda	NOUN
gs-4062	1314	5	dj	dj	NOUN
gs-4062	1314	6	.	.	PUNCT
gs-4062	1314	7	hiv-1	hiv-1	PUNCT
gs-4062	1314	8	antiretroviral	antiretroviral	ADJ
gs-4062	1314	9	drug	drug	NOUN
gs-4062	1314	10	therapy	therapy	NOUN
gs-4062	1314	11	.	.	PUNCT
gs-4062	1315	1	cold	cold	ADJ
gs-4062	1315	2	spring	spring	NOUN
gs-4062	1315	3	harb	harb	PROPN
gs-4062	1315	4	perspect	perspect	PROPN
gs-4062	1315	5	med	med	PROPN
gs-4062	1315	6	.	.	PUNCT
gs-4062	1315	7	2012	2012	NUM
gs-4062	1315	8	apr;2(4):a007161	apr;2(4):a007161	VERB
gs-4062	1315	9	.	.	PROPN
gs-4062	1315	10	74	74	NUM
gs-4062	1315	11	.	.	PUNCT
gs-4062	1316	1	deeks	deek	VERB
gs-4062	1316	2	sg	sg	PROPN
gs-4062	1316	3	,	,	PUNCT
gs-4062	1316	4	lewin	lewin	PROPN
gs-4062	1316	5	sr	sr	PROPN
gs-4062	1316	6	,	,	PUNCT
gs-4062	1316	7	havlir	havlir	PROPN
gs-4062	1316	8	dv	dv	PROPN
gs-4062	1316	9	.	.	PUNCT
gs-4062	1317	1	the	the	DET
gs-4062	1317	2	end	end	NOUN
gs-4062	1317	3	of	of	ADP
gs-4062	1317	4	aids	aids	PROPN
gs-4062	1317	5	:	:	PUNCT
gs-4062	1317	6	hiv	hiv	PROPN
gs-4062	1317	7	infection	infection	NOUN
gs-4062	1317	8	as	as	ADP
gs-4062	1317	9	a	a	DET
gs-4062	1317	10	chronic	chronic	ADJ
gs-4062	1317	11	disease	disease	NOUN
gs-4062	1317	12	.	.	PUNCT
gs-4062	1318	1	lancet	lancet	PROPN
gs-4062	1318	2	.	.	PUNCT
gs-4062	1319	1	2013	2013	NUM
gs-4062	1319	2	nov	nov	PROPN
gs-4062	1319	3	2;382(9903):1525	2;382(9903):1525	NUM
gs-4062	1319	4	-	-	SYM
gs-4062	1319	5	33	33	NUM
gs-4062	1319	6	.	.	PUNCT