id	sid	tid	token	lemma	pos
gs-4132	1	1	georgian	georgian	PROPN
gs-4132	1	2	scientists/	scientists/	NUM
gs-4132	1	3	.	.	PUNCT
gs-4132	2	1	7	7	NUM
gs-4132	2	2	n	n	DET
gs-4132	2	3	4	4	NUM
gs-4132	2	4	,	,	PUNCT
gs-4132	2	5	2025	2025	NUM
gs-4132	2	6	1	1	NUM
gs-4132	2	7	georgian	georgian	PROPN
gs-4132	2	8	scientists	scientist	NOUN
gs-4132	2	9	vol	vol	NOUN
gs-4132	2	10	.	.	PUNCT
gs-4132	2	11	7	7	NUM
gs-4132	2	12	issue	issue	NOUN
gs-4132	2	13	4	4	NUM
gs-4132	2	14	,	,	PUNCT
gs-4132	2	15	2025	2025	NUM
gs-4132	2	16	https://doi.org/10.52340/gs.2025.07.04.01	https://doi.org/10.52340/gs.2025.07.04.01	NOUN
gs-4132	2	17	the	the	DET
gs-4132	2	18	scientific	scientific	ADJ
gs-4132	2	19	talks	talk	NOUN
gs-4132	2	20	of	of	ADP
gs-4132	2	21	manifestation	manifestation	NOUN
gs-4132	2	22	of	of	ADP
gs-4132	2	23	exosomes	exosome	NOUN
gs-4132	2	24	and	and	CCONJ
gs-4132	2	25	small	small	ADJ
gs-4132	2	26	particle	particle	NOUN
gs-4132	2	27	-	-	PUNCT
gs-4132	2	28	based	base	VERB
gs-4132	2	29	therapeutics	therapeutic	NOUN
gs-4132	2	30	:	:	PUNCT
gs-4132	2	31	a	a	DET
gs-4132	2	32	comparative	comparative	ADJ
gs-4132	2	33	review	review	NOUN
gs-4132	2	34	of	of	ADP
gs-4132	2	35	biological	biological	ADJ
gs-4132	2	36	and	and	CCONJ
gs-4132	2	37	synthetic	synthetic	ADJ
gs-4132	2	38	nanocarriers	nanocarrier	NOUN
gs-4132	2	39	nodar	nodar	PROPN
gs-4132	2	40	sulashvili1	sulashvili1	NOUN
gs-4132	2	41	,	,	PUNCT
gs-4132	2	42	valentyna	valentyna	NOUN
gs-4132	2	43	khusseyn2	khusseyn2	PROPN
gs-4132	2	44	,	,	PUNCT
gs-4132	2	45	dalal	dalal	PROPN
gs-4132	2	46	hussin3	hussin3	PROPN
gs-4132	2	47	,	,	PUNCT
gs-4132	2	48	luiza	luiza	PROPN
gs-4132	2	49	gabunia4	gabunia4	PROPN
gs-4132	2	50	,	,	PUNCT
gs-4132	2	51	nana	nana	PROPN
gs-4132	2	52	gorgaslidze5	gorgaslidze5	PROPN
gs-4132	2	53	,	,	PUNCT
gs-4132	2	54	marika	marika	PROPN
gs-4132	2	55	sulashvili6	sulashvili6	PROPN
gs-4132	2	56	,	,	PUNCT
gs-4132	2	57	marina	marina	NOUN
gs-4132	2	58	giorgobiani	giorgobiani	VERB
gs-4132	2	59	7	7	NUM
gs-4132	2	60	,	,	PUNCT
gs-4132	2	61	irine	irine	NOUN
gs-4132	2	62	zarnadze	zarnadze	NOUN
gs-4132	2	63	8	8	NUM
gs-4132	2	64	,	,	PUNCT
gs-4132	2	65	shalva	shalva	NOUN
gs-4132	2	66	(	(	PUNCT
gs-4132	2	67	davit	davit	NOUN
gs-4132	2	68	)	)	PUNCT
gs-4132	2	69	zarnadze	zarnadze	NOUN
gs-4132	2	70	9	9	NUM
gs-4132	2	71	,	,	PUNCT
gs-4132	2	72	david	david	PROPN
gs-4132	2	73	aphkhazava10	aphkhazava10	PROPN
gs-4132	2	74	1	1	NUM
gs-4132	2	75	.	.	PUNCT
gs-4132	3	1	md	md	PROPN
gs-4132	3	2	,	,	PUNCT
gs-4132	3	3	phd	phd	NOUN
gs-4132	3	4	,	,	PUNCT
gs-4132	3	5	doctor	doctor	NOUN
gs-4132	3	6	of	of	ADP
gs-4132	3	7	pharmaceutical	pharmaceutical	ADJ
gs-4132	3	8	and	and	CCONJ
gs-4132	3	9	pharmacological	pharmacological	ADJ
gs-4132	3	10	sciences	science	NOUN
gs-4132	3	11	in	in	ADP
gs-4132	3	12	medicine	medicine	NOUN
gs-4132	3	13	,	,	PUNCT
gs-4132	3	14	invited	invite	VERB
gs-4132	3	15	lecturer	lecturer	NOUN
gs-4132	3	16	(	(	PUNCT
gs-4132	3	17	invited	invite	VERB
gs-4132	3	18	professor	professor	NOUN
gs-4132	3	19	)	)	PUNCT
gs-4132	3	20	of	of	ADP
gs-4132	3	21	scientific	scientific	ADJ
gs-4132	3	22	research	research	NOUN
gs-4132	3	23	-	-	PUNCT
gs-4132	3	24	skills	skill	NOUN
gs-4132	3	25	center	center	NOUN
gs-4132	3	26	at	at	ADP
gs-4132	3	27	tbilisi	tbilisi	PROPN
gs-4132	3	28	state	state	PROPN
gs-4132	3	29	medical	medical	PROPN
gs-4132	3	30	university	university	PROPN
gs-4132	3	31	;	;	PUNCT
gs-4132	3	32	professor	professor	NOUN
gs-4132	3	33	of	of	ADP
gs-4132	3	34	medical	medical	ADJ
gs-4132	3	35	pharmacology	pharmacology	NOUN
gs-4132	3	36	of	of	ADP
gs-4132	3	37	faculty	faculty	NOUN
gs-4132	3	38	of	of	ADP
gs-4132	3	39	medicine	medicine	NOUN
gs-4132	3	40	at	at	ADP
gs-4132	3	41	georgian	georgian	PROPN
gs-4132	3	42	national	national	PROPN
gs-4132	3	43	university	university	PROPN
gs-4132	3	44	seu	seu	NOUN
gs-4132	3	45	;	;	PUNCT
gs-4132	3	46	professor	professor	NOUN
gs-4132	3	47	of	of	ADP
gs-4132	3	48	medical	medical	ADJ
gs-4132	3	49	and	and	CCONJ
gs-4132	3	50	clinical	clinical	ADJ
gs-4132	3	51	pharmacology	pharmacology	NOUN
gs-4132	3	52	of	of	ADP
gs-4132	3	53	international	international	ADJ
gs-4132	3	54	school	school	NOUN
gs-4132	3	55	of	of	ADP
gs-4132	3	56	medicine	medicine	NOUN
gs-4132	3	57	at	at	ADP
gs-4132	3	58	alte	alte	PROPN
gs-4132	3	59	university	university	PROPN
gs-4132	3	60	;	;	PUNCT
gs-4132	3	61	invited	invite	VERB
gs-4132	3	62	lecturer	lecturer	NOUN
gs-4132	3	63	of	of	ADP
gs-4132	3	64	clinical	clinical	ADJ
gs-4132	3	65	pharmacology	pharmacology	NOUN
gs-4132	3	66	department	department	NOUN
gs-4132	3	67	at	at	ADP
gs-4132	3	68	tbilisi	tbilisi	PROPN
gs-4132	3	69	state	state	PROPN
gs-4132	3	70	medical	medical	PROPN
gs-4132	3	71	university	university	PROPN
gs-4132	3	72	;	;	PUNCT
gs-4132	3	73	tbilisi	tbilisi	PROPN
gs-4132	3	74	,	,	PUNCT
gs-4132	3	75	georgia	georgia	PROPN
gs-4132	3	76	;	;	PUNCT
gs-4132	3	77	orcid	orcid	PROPN
gs-4132	3	78	https://orcid.org/0000-0002-9005-8577	https://orcid.org/0000-0002-9005-8577	PROPN
gs-4132	3	79	;	;	PUNCT
gs-4132	3	80	e	e	X
gs-4132	3	81	-	-	NOUN
gs-4132	3	82	mail	mail	NOUN
gs-4132	3	83	:	:	PUNCT
gs-4132	3	84	n.sulashvili@ug.edu.ge	n.sulashvili@ug.edu.ge	NOUN
gs-4132	3	85	2	2	NUM
gs-4132	3	86	.	.	PUNCT
gs-4132	4	1	the	the	DET
gs-4132	4	2	second	second	ADJ
gs-4132	4	3	year	year	NOUN
gs-4132	4	4	student	student	NOUN
gs-4132	4	5	of	of	ADP
gs-4132	4	6	faculty	faculty	NOUN
gs-4132	4	7	of	of	ADP
gs-4132	4	8	physical	physical	ADJ
gs-4132	4	9	medicine	medicine	NOUN
gs-4132	4	10	and	and	CCONJ
gs-4132	4	11	rehabilitation	rehabilitation	NOUN
gs-4132	4	12	at	at	ADP
gs-4132	4	13	tbilisi	tbilisi	PROPN
gs-4132	4	14	state	state	PROPN
gs-4132	4	15	medical	medical	PROPN
gs-4132	4	16	university	university	PROPN
gs-4132	4	17	,	,	PUNCT
gs-4132	4	18	tbilisi	tbilisi	PROPN
gs-4132	4	19	,	,	PUNCT
gs-4132	4	20	georgia	georgia	PROPN
gs-4132	4	21	;	;	PUNCT
gs-4132	4	22	3	3	NUM
gs-4132	4	23	.	.	NOUN
gs-4132	4	24	fifth	fifth	ADJ
gs-4132	4	25	year	year	NOUN
gs-4132	4	26	md	md	PROPN
gs-4132	4	27	student	student	NOUN
gs-4132	4	28	of	of	ADP
gs-4132	4	29	medical	medical	ADJ
gs-4132	4	30	doctor	doctor	NOUN
gs-4132	4	31	degree	degree	NOUN
gs-4132	4	32	program	program	NOUN
gs-4132	4	33	of	of	ADP
gs-4132	4	34	faculty	faculty	NOUN
gs-4132	4	35	of	of	ADP
gs-4132	4	36	medicine	medicine	NOUN
gs-4132	4	37	at	at	ADP
gs-4132	4	38	tbilisi	tbilisi	PROPN
gs-4132	4	39	state	state	PROPN
gs-4132	4	40	medical	medical	PROPN
gs-4132	4	41	university	university	PROPN
gs-4132	4	42	;	;	PUNCT
gs-4132	4	43	tbilisi	tbilisi	PROPN
gs-4132	4	44	,	,	PUNCT
gs-4132	4	45	georgia	georgia	PROPN
gs-4132	4	46	;	;	PUNCT
gs-4132	4	47	4	4	NUM
gs-4132	4	48	.	.	X
gs-4132	4	49	md	md	PROPN
gs-4132	4	50	,	,	PUNCT
gs-4132	4	51	phd	phd	NOUN
gs-4132	4	52	,	,	PUNCT
gs-4132	4	53	doctor	doctor	NOUN
gs-4132	4	54	of	of	ADP
gs-4132	4	55	medical	medical	ADJ
gs-4132	4	56	sciences	sciences	PROPN
gs-4132	4	57	,	,	PUNCT
gs-4132	4	58	professor	professor	NOUN
gs-4132	4	59	,	,	PUNCT
gs-4132	4	60	director	director	NOUN
gs-4132	4	61	of	of	ADP
gs-4132	4	62	the	the	DET
gs-4132	4	63	scientific	scientific	ADJ
gs-4132	4	64	research	research	NOUN
gs-4132	4	65	-	-	PUNCT
gs-4132	4	66	skills	skill	NOUN
gs-4132	4	67	center	center	NOUN
gs-4132	4	68	at	at	ADP
gs-4132	4	69	tbilisi	tbilisi	PROPN
gs-4132	4	70	state	state	PROPN
gs-4132	4	71	medical	medical	PROPN
gs-4132	4	72	university	university	PROPN
gs-4132	4	73	,	,	PUNCT
gs-4132	4	74	professor	professor	NOUN
gs-4132	4	75	,	,	PUNCT
gs-4132	4	76	head	head	NOUN
gs-4132	4	77	of	of	ADP
gs-4132	4	78	the	the	DET
gs-4132	4	79	department	department	PROPN
gs-4132	4	80	of	of	ADP
gs-4132	4	81	medical	medical	ADJ
gs-4132	4	82	and	and	CCONJ
gs-4132	4	83	clinical	clinical	ADJ
gs-4132	4	84	pharmacology	pharmacology	NOUN
gs-4132	4	85	at	at	ADP
gs-4132	4	86	tbilisi	tbilisi	PROPN
gs-4132	4	87	state	state	PROPN
gs-4132	4	88	medical	medical	PROPN
gs-4132	4	89	university	university	PROPN
gs-4132	4	90	,	,	PUNCT
gs-4132	4	91	clinical	clinical	ADJ
gs-4132	4	92	pharmacologist	pharmacologist	NOUN
gs-4132	4	93	of	of	ADP
gs-4132	4	94	the	the	DET
gs-4132	4	95	first	first	ADJ
gs-4132	4	96	university	university	NOUN
gs-4132	4	97	clinic	clinic	NOUN
gs-4132	4	98	of	of	ADP
gs-4132	4	99	tsmu	tsmu	PROPN
gs-4132	4	100	,	,	PUNCT
gs-4132	4	101	tbilisi	tbilisi	PROPN
gs-4132	4	102	,	,	PUNCT
gs-4132	4	103	georgia	georgia	PROPN
gs-4132	4	104	https://orcid.org/0000-0003-0856-2684	https://orcid.org/0000-0003-0856-2684	PROPN
gs-4132	4	105	5	5	NUM
gs-4132	4	106	.	.	PUNCT
gs-4132	4	107	md	md	PROPN
gs-4132	4	108	,	,	PUNCT
gs-4132	4	109	phd	phd	NOUN
gs-4132	4	110	,	,	PUNCT
gs-4132	4	111	doctor	doctor	NOUN
gs-4132	4	112	of	of	ADP
gs-4132	4	113	pharmaceutical	pharmaceutical	NOUN
gs-4132	4	114	sciences	science	NOUN
gs-4132	4	115	,	,	PUNCT
gs-4132	4	116	academician	academician	NOUN
gs-4132	4	117	,	,	PUNCT
gs-4132	4	118	professor	professor	NOUN
gs-4132	4	119	of	of	ADP
gs-4132	4	120	tbilisi	tbilisi	PROPN
gs-4132	4	121	state	state	PROPN
gs-4132	4	122	medical	medical	PROPN
gs-4132	4	123	university	university	PROPN
gs-4132	4	124	,	,	PUNCT
gs-4132	4	125	head	head	NOUN
gs-4132	4	126	of	of	ADP
gs-4132	4	127	the	the	DET
gs-4132	4	128	department	department	NOUN
gs-4132	4	129	of	of	ADP
gs-4132	4	130	social	social	ADJ
gs-4132	4	131	and	and	CCONJ
gs-4132	4	132	clinical	clinical	ADJ
gs-4132	4	133	pharmacy	pharmacy	NOUN
gs-4132	4	134	,	,	PUNCT
gs-4132	4	135	tbilisi	tbilisi	PROPN
gs-4132	4	136	,	,	PUNCT
gs-4132	4	137	georgia	georgia	PROPN
gs-4132	4	138	.	.	PUNCT
gs-4132	5	1	https://orcid.org/0000-00024563-5224	https://orcid.org/0000-00024563-5224	PROPN
gs-4132	5	2	6	6	NUM
gs-4132	5	3	.	.	PUNCT
gs-4132	6	1	md	md	PROPN
gs-4132	6	2	,	,	PUNCT
gs-4132	6	3	doctor	doctor	NOUN
gs-4132	6	4	of	of	ADP
gs-4132	6	5	family	family	NOUN
gs-4132	6	6	medicine	medicine	NOUN
gs-4132	6	7	,	,	PUNCT
gs-4132	6	8	invited	invite	VERB
gs-4132	6	9	lecturer	lecturer	NOUN
gs-4132	6	10	of	of	ADP
gs-4132	6	11	tbilisi	tbilisi	PROPN
gs-4132	6	12	state	state	PROPN
gs-4132	6	13	medical	medical	PROPN
gs-4132	6	14	university	university	PROPN
gs-4132	6	15	,	,	PUNCT
gs-4132	6	16	department	department	NOUN
gs-4132	6	17	of	of	ADP
gs-4132	6	18	molecular	molecular	ADJ
gs-4132	6	19	and	and	CCONJ
gs-4132	6	20	medical	medical	ADJ
gs-4132	6	21	genetics	genetic	NOUN
gs-4132	6	22	;	;	PUNCT
gs-4132	6	23	invited	invite	VERB
gs-4132	6	24	lecturer	lecturer	NOUN
gs-4132	6	25	of	of	ADP
gs-4132	6	26	family	family	NOUN
gs-4132	6	27	medicine	medicine	NOUN
gs-4132	6	28	of	of	ADP
gs-4132	6	29	faculty	faculty	NOUN
gs-4132	6	30	of	of	ADP
gs-4132	6	31	medicine	medicine	NOUN
gs-4132	6	32	at	at	ADP
gs-4132	6	33	georgian	georgian	PROPN
gs-4132	6	34	national	national	PROPN
gs-4132	6	35	university	university	PROPN
gs-4132	6	36	seu	seu	NOUN
gs-4132	6	37	;	;	PUNCT
gs-4132	6	38	invited	invite	VERB
gs-4132	6	39	professor	professor	NOUN
gs-4132	6	40	of	of	ADP
gs-4132	6	41	biochemistry	biochemistry	NOUN
gs-4132	6	42	and	and	CCONJ
gs-4132	6	43	molecular	molecular	ADJ
gs-4132	6	44	and	and	CCONJ
gs-4132	6	45	medical	medical	ADJ
gs-4132	6	46	genetics	genetic	NOUN
gs-4132	6	47	at	at	ADP
gs-4132	6	48	the	the	DET
gs-4132	6	49	university	university	PROPN
gs-4132	6	50	of	of	ADP
gs-4132	6	51	georgia	georgia	PROPN
gs-4132	6	52	;	;	PUNCT
gs-4132	6	53	tbilisi	tbilisi	PROPN
gs-4132	6	54	,	,	PUNCT
gs-4132	6	55	georgia	georgia	PROPN
gs-4132	6	56	.	.	PUNCT
gs-4132	7	1	7	7	X
gs-4132	7	2	.	.	X
gs-4132	7	3	md	md	PROPN
gs-4132	7	4	,	,	PUNCT
gs-4132	7	5	phd	phd	NOUN
gs-4132	7	6	,	,	PUNCT
gs-4132	7	7	doctor	doctor	NOUN
gs-4132	7	8	of	of	ADP
gs-4132	7	9	medical	medical	ADJ
gs-4132	7	10	sciences	science	NOUN
gs-4132	7	11	,	,	PUNCT
gs-4132	7	12	academician	academician	NOUN
gs-4132	7	13	,	,	PUNCT
gs-4132	7	14	professor	professor	NOUN
gs-4132	7	15	of	of	ADP
gs-4132	7	16	tbilisi	tbilisi	PROPN
gs-4132	7	17	state	state	PROPN
gs-4132	7	18	medical	medical	PROPN
gs-4132	7	19	university	university	NOUN
gs-4132	7	20	,	,	PUNCT
gs-4132	7	21	faculty	faculty	NOUN
gs-4132	7	22	of	of	ADP
gs-4132	7	23	public	public	ADJ
gs-4132	7	24	health	health	NOUN
gs-4132	7	25	;	;	PUNCT
gs-4132	7	26	department	department	NOUN
gs-4132	7	27	of	of	ADP
gs-4132	7	28	hygiene	hygiene	NOUN
gs-4132	7	29	and	and	CCONJ
gs-4132	7	30	medical	medical	ADJ
gs-4132	7	31	ecology	ecology	NOUN
gs-4132	7	32	,	,	PUNCT
gs-4132	7	33	tbilisi	tbilisi	PROPN
gs-4132	7	34	,	,	PUNCT
gs-4132	7	35	georgia	georgia	PROPN
gs-4132	7	36	.	.	PUNCT
gs-4132	8	1	https://orcid.org/0000-0003-0686-5227	https://orcid.org/0000-0003-0686-5227	PROPN
gs-4132	8	2	8	8	NUM
gs-4132	8	3	.	.	PUNCT
gs-4132	9	1	md	md	PROPN
gs-4132	9	2	,	,	PUNCT
gs-4132	9	3	phd	phd	NOUN
gs-4132	9	4	,	,	PUNCT
gs-4132	9	5	doctor	doctor	NOUN
gs-4132	9	6	of	of	ADP
gs-4132	9	7	medical	medical	ADJ
gs-4132	9	8	sciences	science	NOUN
gs-4132	9	9	,	,	PUNCT
gs-4132	9	10	professor	professor	NOUN
gs-4132	9	11	of	of	ADP
gs-4132	9	12	tbilisi	tbilisi	PROPN
gs-4132	9	13	state	state	PROPN
gs-4132	9	14	medical	medical	PROPN
gs-4132	9	15	university	university	PROPN
gs-4132	9	16	,	,	PUNCT
gs-4132	9	17	department	department	NOUN
gs-4132	9	18	of	of	ADP
gs-4132	9	19	public	public	ADJ
gs-4132	9	20	health	health	NOUN
gs-4132	9	21	,	,	PUNCT
gs-4132	9	22	health	health	NOUN
gs-4132	9	23	care	care	NOUN
gs-4132	9	24	management	management	NOUN
gs-4132	9	25	,	,	PUNCT
gs-4132	9	26	policy	policy	NOUN
gs-4132	9	27	and	and	CCONJ
gs-4132	9	28	economy	economy	NOUN
gs-4132	9	29	,	,	PUNCT
gs-4132	9	30	tbilisi	tbilisi	PROPN
gs-4132	9	31	,	,	PUNCT
gs-4132	9	32	georgia	georgia	PROPN
gs-4132	9	33	.	.	PUNCT
gs-4132	10	1	9	9	X
gs-4132	10	2	.	.	X
gs-4132	10	3	md	md	PROPN
gs-4132	10	4	,	,	PUNCT
gs-4132	10	5	phd	phd	NOUN
gs-4132	10	6	,	,	PUNCT
gs-4132	10	7	doctor	doctor	NOUN
gs-4132	10	8	of	of	ADP
gs-4132	10	9	medical	medical	ADJ
gs-4132	10	10	sciences	science	NOUN
gs-4132	10	11	,	,	PUNCT
gs-4132	10	12	academician	academician	NOUN
gs-4132	10	13	,	,	PUNCT
gs-4132	10	14	professor	professor	NOUN
gs-4132	10	15	of	of	ADP
gs-4132	10	16	tbilisi	tbilisi	PROPN
gs-4132	10	17	state	state	PROPN
gs-4132	10	18	medical	medical	PROPN
gs-4132	10	19	university	university	PROPN
gs-4132	10	20	,	,	PUNCT
gs-4132	10	21	dean	dean	NOUN
gs-4132	10	22	of	of	ADP
gs-4132	10	23	the	the	DET
gs-4132	10	24	faculty	faculty	NOUN
gs-4132	10	25	of	of	ADP
gs-4132	10	26	public	public	ADJ
gs-4132	10	27	health	health	NOUN
gs-4132	10	28	,	,	PUNCT
gs-4132	10	29	head	head	NOUN
gs-4132	10	30	of	of	ADP
gs-4132	10	31	the	the	DET
gs-4132	10	32	department	department	NOUN
gs-4132	10	33	of	of	ADP
gs-4132	10	34	nutrition	nutrition	NOUN
gs-4132	10	35	,	,	PUNCT
gs-4132	10	36	aging	age	VERB
gs-4132	10	37	medicine	medicine	NOUN
gs-4132	10	38	,	,	PUNCT
gs-4132	10	39	environmental	environmental	ADJ
gs-4132	10	40	and	and	CCONJ
gs-4132	10	41	occupational	occupational	ADJ
gs-4132	10	42	health	health	NOUN
gs-4132	10	43	,	,	PUNCT
gs-4132	10	44	tbilisi	tbilisi	PROPN
gs-4132	10	45	,	,	PUNCT
gs-4132	10	46	georgia	georgia	PROPN
gs-4132	10	47	.	.	PUNCT
gs-4132	11	1	10	10	NUM
gs-4132	11	2	.	.	X
gs-4132	12	1	phd	phd	NOUN
gs-4132	12	2	,	,	PUNCT
gs-4132	12	3	full	full	ADJ
gs-4132	12	4	professor	professor	NOUN
gs-4132	12	5	of	of	ADP
gs-4132	12	6	biochemistry	biochemistry	NOUN
gs-4132	12	7	at	at	ADP
gs-4132	12	8	alte	alte	PROPN
gs-4132	12	9	university	university	PROPN
gs-4132	12	10	,	,	PUNCT
gs-4132	12	11	tbilisi	tbilisi	PROPN
gs-4132	12	12	,	,	PUNCT
gs-4132	12	13	georgia	georgia	PROPN
gs-4132	12	14	;	;	PUNCT
gs-4132	12	15	invited	invite	VERB
gs-4132	12	16	lecturer	lecturer	NOUN
gs-4132	12	17	(	(	PUNCT
gs-4132	12	18	professor	professor	NOUN
gs-4132	12	19	)	)	PUNCT
gs-4132	12	20	of	of	ADP
gs-4132	12	21	biochemistry	biochemistry	NOUN
gs-4132	12	22	,	,	PUNCT
gs-4132	12	23	university	university	PROPN
gs-4132	12	24	of	of	ADP
gs-4132	12	25	georgia	georgia	PROPN
gs-4132	12	26	,	,	PUNCT
gs-4132	12	27	tbilisi	tbilisi	PROPN
gs-4132	12	28	georgia	georgia	PROPN
gs-4132	12	29	,	,	PUNCT
gs-4132	12	30	full	full	ADJ
gs-4132	12	31	professor	professor	NOUN
gs-4132	12	32	of	of	ADP
gs-4132	12	33	biochemistry	biochemistry	NOUN
gs-4132	12	34	georgian	georgian	PROPN
gs-4132	12	35	national	national	PROPN
gs-4132	12	36	georgian	georgian	PROPN
gs-4132	12	37	scientists/	scientists/	NUM
gs-4132	12	38	.	.	PUNCT
gs-4132	13	1	7	7	NUM
gs-4132	13	2	n	n	DET
gs-4132	13	3	4	4	NUM
gs-4132	13	4	,	,	PUNCT
gs-4132	13	5	2025	2025	NUM
gs-4132	13	6	2	2	NUM
gs-4132	13	7	university	university	NOUN
gs-4132	13	8	seu	seu	NOUN
gs-4132	13	9	,	,	PUNCT
gs-4132	13	10	tbilisi	tbilisi	PROPN
gs-4132	13	11	georgia	georgia	PROPN
gs-4132	13	12	,	,	PUNCT
gs-4132	13	13	invited	invite	VERB
gs-4132	13	14	lecturer	lecturer	NOUN
gs-4132	13	15	(	(	PUNCT
gs-4132	13	16	professor	professor	NOUN
gs-4132	13	17	)	)	PUNCT
gs-4132	13	18	of	of	ADP
gs-4132	13	19	biophysics	biophysic	NOUN
gs-4132	13	20	and	and	CCONJ
gs-4132	13	21	microbiology	microbiology	NOUN
gs-4132	13	22	,	,	PUNCT
gs-4132	13	23	georgian	georgian	PROPN
gs-4132	13	24	technical	technical	PROPN
gs-4132	13	25	university	university	PROPN
gs-4132	13	26	,	,	PUNCT
gs-4132	13	27	tbilisi	tbilisi	PROPN
gs-4132	13	28	,	,	PUNCT
gs-4132	13	29	georgia	georgia	PROPN
gs-4132	13	30	.	.	PUNCT
gs-4132	14	1	orcid	orcid	PROPN
gs-4132	14	2	:	:	PUNCT
gs-4132	14	3	https://orcid.org/0000-0001-6216-647	https://orcid.org/0000-0001-6216-647	PROPN
gs-4132	14	4	corresponding	corresponding	ADJ
gs-4132	14	5	author	author	NOUN
gs-4132	14	6	:	:	PUNCT
gs-4132	14	7	dr	dr	PROPN
gs-4132	14	8	.	.	PROPN
gs-4132	14	9	professor	professor	PROPN
gs-4132	14	10	nodar	nodar	PROPN
gs-4132	14	11	sulashvili	sulashvili	PROPN
gs-4132	14	12	mail	mail	NOUN
gs-4132	14	13	:	:	PUNCT
gs-4132	14	14	n.sulashvili@ug.edu.ge	n.sulashvili@ug.edu.ge	NOUN
gs-4132	14	15	mob	mob	NOUN
gs-4132	14	16	:	:	PUNCT
gs-4132	15	1	+995	+995	ADJ
gs-4132	15	2	-	-	ADJ
gs-4132	15	3	597	597	NUM
gs-4132	15	4	-	-	PUNCT
gs-4132	15	5	12	12	NUM
gs-4132	15	6	-	-	PUNCT
gs-4132	15	7	17	17	NUM
gs-4132	15	8	-	-	SYM
gs-4132	15	9	28	28	NUM
gs-4132	15	10	abstract	abstract	ADJ
gs-4132	15	11	exosomes	exosome	NOUN
gs-4132	15	12	and	and	CCONJ
gs-4132	15	13	other	other	ADJ
gs-4132	15	14	small	small	ADJ
gs-4132	15	15	particles	particle	NOUN
gs-4132	15	16	,	,	PUNCT
gs-4132	15	17	such	such	ADJ
gs-4132	15	18	as	as	ADP
gs-4132	15	19	liposomes	liposome	NOUN
gs-4132	15	20	,	,	PUNCT
gs-4132	15	21	polymeric	polymeric	ADJ
gs-4132	15	22	nanoparticles	nanoparticle	NOUN
gs-4132	15	23	,	,	PUNCT
gs-4132	15	24	and	and	CCONJ
gs-4132	15	25	extracellular	extracellular	ADJ
gs-4132	15	26	vesicle	vesicle	NOUN
gs-4132	15	27	(	(	PUNCT
gs-4132	15	28	ev)-mimetics	ev)-mimetic	NOUN
gs-4132	15	29	,	,	PUNCT
gs-4132	15	30	have	have	AUX
gs-4132	15	31	emerged	emerge	VERB
gs-4132	15	32	as	as	ADP
gs-4132	15	33	central	central	ADJ
gs-4132	15	34	players	player	NOUN
gs-4132	15	35	in	in	ADP
gs-4132	15	36	the	the	DET
gs-4132	15	37	development	development	NOUN
gs-4132	15	38	of	of	ADP
gs-4132	15	39	next	next	ADJ
gs-4132	15	40	-	-	PUNCT
gs-4132	15	41	generation	generation	NOUN
gs-4132	15	42	therapeutics	therapeutic	NOUN
gs-4132	15	43	.	.	PUNCT
gs-4132	16	1	exosomes	exosome	NOUN
gs-4132	16	2	are	be	AUX
gs-4132	16	3	nanoscale	nanoscale	ADJ
gs-4132	16	4	vesicles	vesicle	NOUN
gs-4132	16	5	of	of	ADP
gs-4132	16	6	endosomal	endosomal	ADJ
gs-4132	16	7	origin	origin	NOUN
gs-4132	16	8	secreted	secrete	VERB
gs-4132	16	9	by	by	ADP
gs-4132	16	10	nearly	nearly	ADV
gs-4132	16	11	all	all	DET
gs-4132	16	12	cell	cell	NOUN
gs-4132	16	13	types	type	NOUN
gs-4132	16	14	,	,	PUNCT
gs-4132	16	15	playing	play	VERB
gs-4132	16	16	a	a	DET
gs-4132	16	17	critical	critical	ADJ
gs-4132	16	18	role	role	NOUN
gs-4132	16	19	in	in	ADP
gs-4132	16	20	cell	cell	NOUN
gs-4132	16	21	–	–	PUNCT
gs-4132	16	22	cell	cell	NOUN
gs-4132	16	23	communication	communication	NOUN
gs-4132	16	24	through	through	ADP
gs-4132	16	25	their	their	PRON
gs-4132	16	26	unique	unique	ADJ
gs-4132	16	27	cargo	cargo	NOUN
gs-4132	16	28	of	of	ADP
gs-4132	16	29	nucleic	nucleic	ADJ
gs-4132	16	30	acids	acid	NOUN
gs-4132	16	31	,	,	PUNCT
gs-4132	16	32	proteins	protein	NOUN
gs-4132	16	33	,	,	PUNCT
gs-4132	16	34	and	and	CCONJ
gs-4132	16	35	lipids	lipid	NOUN
gs-4132	16	36	.	.	PUNCT
gs-4132	17	1	liposomes	liposome	NOUN
gs-4132	17	2	,	,	PUNCT
gs-4132	17	3	in	in	ADP
gs-4132	17	4	contrast	contrast	NOUN
gs-4132	17	5	,	,	PUNCT
gs-4132	17	6	are	be	AUX
gs-4132	17	7	synthetic	synthetic	ADJ
gs-4132	17	8	lipid	lipid	NOUN
gs-4132	17	9	vesicles	vesicle	NOUN
gs-4132	17	10	that	that	PRON
gs-4132	17	11	have	have	AUX
gs-4132	17	12	been	be	AUX
gs-4132	17	13	successfully	successfully	ADV
gs-4132	17	14	used	use	VERB
gs-4132	17	15	in	in	ADP
gs-4132	17	16	clinical	clinical	ADJ
gs-4132	17	17	practice	practice	NOUN
gs-4132	17	18	for	for	ADP
gs-4132	17	19	decades	decade	NOUN
gs-4132	17	20	as	as	ADP
gs-4132	17	21	drug	drug	NOUN
gs-4132	17	22	carriers	carrier	NOUN
gs-4132	17	23	.	.	PUNCT
gs-4132	18	1	a	a	DET
gs-4132	18	2	comparative	comparative	ADJ
gs-4132	18	3	assessment	assessment	NOUN
gs-4132	18	4	of	of	ADP
gs-4132	18	5	these	these	DET
gs-4132	18	6	natural	natural	ADJ
gs-4132	18	7	and	and	CCONJ
gs-4132	18	8	synthetic	synthetic	ADJ
gs-4132	18	9	nanocarriers	nanocarrier	NOUN
gs-4132	18	10	highlights	highlight	NOUN
gs-4132	18	11	differences	difference	NOUN
gs-4132	18	12	in	in	ADP
gs-4132	18	13	biogenesis	biogenesis	NOUN
gs-4132	18	14	,	,	PUNCT
gs-4132	18	15	composition	composition	NOUN
gs-4132	18	16	,	,	PUNCT
gs-4132	18	17	immunogenicity	immunogenicity	NOUN
gs-4132	18	18	,	,	PUNCT
gs-4132	18	19	pharmacokinetics	pharmacokinetic	NOUN
gs-4132	18	20	,	,	PUNCT
gs-4132	18	21	scalability	scalability	NOUN
gs-4132	18	22	,	,	PUNCT
gs-4132	18	23	and	and	CCONJ
gs-4132	18	24	translational	translational	ADJ
gs-4132	18	25	potential	potential	NOUN
gs-4132	18	26	.	.	PUNCT
gs-4132	19	1	exosomes	exosome	NOUN
gs-4132	19	2	offer	offer	VERB
gs-4132	19	3	the	the	DET
gs-4132	19	4	advantage	advantage	NOUN
gs-4132	19	5	of	of	ADP
gs-4132	19	6	natural	natural	ADJ
gs-4132	19	7	biocompatibility	biocompatibility	NOUN
gs-4132	19	8	and	and	CCONJ
gs-4132	19	9	intrinsic	intrinsic	ADJ
gs-4132	19	10	targeting	targeting	NOUN
gs-4132	19	11	abilities	ability	NOUN
gs-4132	19	12	,	,	PUNCT
gs-4132	19	13	while	while	SCONJ
gs-4132	19	14	liposomes	liposome	NOUN
gs-4132	19	15	and	and	CCONJ
gs-4132	19	16	other	other	ADJ
gs-4132	19	17	engineered	engineer	VERB
gs-4132	19	18	nanoparticles	nanoparticle	NOUN
gs-4132	19	19	provide	provide	VERB
gs-4132	19	20	reproducibility	reproducibility	NOUN
gs-4132	19	21	,	,	PUNCT
gs-4132	19	22	stability	stability	NOUN
gs-4132	19	23	,	,	PUNCT
gs-4132	19	24	and	and	CCONJ
gs-4132	19	25	regulatory	regulatory	ADJ
gs-4132	19	26	precedent	precedent	NOUN
gs-4132	19	27	.	.	PUNCT
gs-4132	20	1	in	in	ADP
gs-4132	20	2	this	this	DET
gs-4132	20	3	review	review	NOUN
gs-4132	20	4	,	,	PUNCT
gs-4132	20	5	we	we	PRON
gs-4132	20	6	provide	provide	VERB
gs-4132	20	7	an	an	DET
gs-4132	20	8	in	in	ADP
gs-4132	20	9	-	-	PUNCT
gs-4132	20	10	depth	depth	NOUN
gs-4132	20	11	overview	overview	NOUN
gs-4132	20	12	of	of	ADP
gs-4132	20	13	exosomes	exosome	NOUN
gs-4132	20	14	,	,	PUNCT
gs-4132	20	15	liposomes	liposome	NOUN
gs-4132	20	16	,	,	PUNCT
gs-4132	20	17	and	and	CCONJ
gs-4132	20	18	other	other	ADJ
gs-4132	20	19	nanoparticle	nanoparticle	NOUN
gs-4132	20	20	systems	system	NOUN
gs-4132	20	21	,	,	PUNCT
gs-4132	20	22	exploring	explore	VERB
gs-4132	20	23	their	their	PRON
gs-4132	20	24	structural	structural	ADJ
gs-4132	20	25	and	and	CCONJ
gs-4132	20	26	functional	functional	ADJ
gs-4132	20	27	properties	property	NOUN
gs-4132	20	28	,	,	PUNCT
gs-4132	20	29	therapeutic	therapeutic	ADJ
gs-4132	20	30	applications	application	NOUN
gs-4132	20	31	across	across	ADP
gs-4132	20	32	multiple	multiple	ADJ
gs-4132	20	33	disease	disease	NOUN
gs-4132	20	34	domains	domain	NOUN
gs-4132	20	35	,	,	PUNCT
gs-4132	20	36	and	and	CCONJ
gs-4132	20	37	the	the	DET
gs-4132	20	38	challenges	challenge	NOUN
gs-4132	20	39	that	that	PRON
gs-4132	20	40	must	must	AUX
gs-4132	20	41	be	be	AUX
gs-4132	20	42	overcome	overcome	VERB
gs-4132	20	43	for	for	ADP
gs-4132	20	44	clinical	clinical	ADJ
gs-4132	20	45	translation	translation	NOUN
gs-4132	20	46	.	.	PUNCT
gs-4132	21	1	keywords	keyword	NOUN
gs-4132	21	2	:	:	PUNCT
gs-4132	21	3	exosomes	exosome	NOUN
gs-4132	21	4	,	,	PUNCT
gs-4132	21	5	liposomes	liposome	NOUN
gs-4132	21	6	,	,	PUNCT
gs-4132	21	7	extracellular	extracellular	ADJ
gs-4132	21	8	vesicles	vesicle	NOUN
gs-4132	21	9	,	,	PUNCT
gs-4132	21	10	nanoparticles	nanoparticle	NOUN
gs-4132	21	11	,	,	PUNCT
gs-4132	21	12	drug	drug	NOUN
gs-4132	21	13	delivery	delivery	NOUN
gs-4132	21	14	,	,	PUNCT
gs-4132	21	15	regenerative	regenerative	ADJ
gs-4132	21	16	medicine	medicine	NOUN
gs-4132	21	17	,	,	PUNCT
gs-4132	21	18	cancer	cancer	NOUN
gs-4132	21	19	therapy	therapy	NOUN
gs-4132	21	20	,	,	PUNCT
gs-4132	21	21	neurodegeneration	neurodegeneration	NOUN
gs-4132	21	22	,	,	PUNCT
gs-4132	21	23	nanomedicine	nanomedicine	NOUN
gs-4132	21	24	.	.	PUNCT
gs-4132	22	1	1	1	NUM
gs-4132	22	2	.	.	X
gs-4132	22	3	introduction	introduction	NOUN
gs-4132	22	4	1.1	1.1	NUM
gs-4132	22	5	the	the	DET
gs-4132	22	6	rise	rise	NOUN
gs-4132	22	7	of	of	ADP
gs-4132	22	8	nanomedicine	nanomedicine	ADJ
gs-4132	22	9	nanomedicine	nanomedicine	NOUN
gs-4132	22	10	has	have	AUX
gs-4132	22	11	become	become	VERB
gs-4132	22	12	one	one	NUM
gs-4132	22	13	of	of	ADP
gs-4132	22	14	the	the	DET
gs-4132	22	15	fastest	fast	ADV
gs-4132	22	16	-	-	PUNCT
gs-4132	22	17	growing	grow	VERB
gs-4132	22	18	fields	field	NOUN
gs-4132	22	19	in	in	ADP
gs-4132	22	20	biomedical	biomedical	ADJ
gs-4132	22	21	sciences	science	NOUN
gs-4132	22	22	,	,	PUNCT
gs-4132	22	23	offering	offer	VERB
gs-4132	22	24	new	new	ADJ
gs-4132	22	25	approaches	approach	NOUN
gs-4132	22	26	for	for	ADP
gs-4132	22	27	targeted	target	VERB
gs-4132	22	28	drug	drug	NOUN
gs-4132	22	29	delivery	delivery	NOUN
gs-4132	22	30	,	,	PUNCT
gs-4132	22	31	diagnostic	diagnostic	ADJ
gs-4132	22	32	imaging	imaging	NOUN
gs-4132	22	33	,	,	PUNCT
gs-4132	22	34	regenerative	regenerative	ADJ
gs-4132	22	35	medicine	medicine	NOUN
gs-4132	22	36	,	,	PUNCT
gs-4132	22	37	and	and	CCONJ
gs-4132	22	38	personalized	personalized	ADJ
gs-4132	22	39	therapeutics	therapeutic	NOUN
gs-4132	22	40	(	(	PUNCT
gs-4132	22	41	shi	shi	PROPN
gs-4132	22	42	et	et	PROPN
gs-4132	22	43	al	al	PROPN
gs-4132	22	44	.	.	PROPN
gs-4132	22	45	,	,	PUNCT
gs-4132	22	46	2017	2017	NUM
gs-4132	22	47	)	)	PUNCT
gs-4132	22	48	.	.	PUNCT
gs-4132	23	1	traditional	traditional	ADJ
gs-4132	23	2	pharmacological	pharmacological	ADJ
gs-4132	23	3	strategies	strategy	NOUN
gs-4132	23	4	face	face	VERB
gs-4132	23	5	limitations	limitation	NOUN
gs-4132	23	6	such	such	ADJ
gs-4132	23	7	as	as	ADP
gs-4132	23	8	poor	poor	ADJ
gs-4132	23	9	bioavailability	bioavailability	NOUN
gs-4132	23	10	,	,	PUNCT
gs-4132	23	11	systemic	systemic	ADJ
gs-4132	23	12	toxicity	toxicity	NOUN
gs-4132	23	13	,	,	PUNCT
gs-4132	23	14	and	and	CCONJ
gs-4132	23	15	lack	lack	NOUN
gs-4132	23	16	of	of	ADP
gs-4132	23	17	tissue	tissue	NOUN
gs-4132	23	18	specificity	specificity	NOUN
gs-4132	23	19	.	.	PUNCT
gs-4132	24	1	nanoparticles	nanoparticle	NOUN
gs-4132	24	2	,	,	PUNCT
gs-4132	24	3	owing	owe	VERB
gs-4132	24	4	to	to	ADP
gs-4132	24	5	their	their	PRON
gs-4132	24	6	tunable	tunable	ADJ
gs-4132	24	7	size	size	NOUN
gs-4132	24	8	,	,	PUNCT
gs-4132	24	9	surface	surface	NOUN
gs-4132	24	10	chemistry	chemistry	NOUN
gs-4132	24	11	,	,	PUNCT
gs-4132	24	12	and	and	CCONJ
gs-4132	24	13	ability	ability	NOUN
gs-4132	24	14	to	to	PART
gs-4132	24	15	cross	cross	VERB
gs-4132	24	16	biological	biological	ADJ
gs-4132	24	17	barriers	barrier	NOUN
gs-4132	24	18	,	,	PUNCT
gs-4132	24	19	have	have	AUX
gs-4132	24	20	been	be	AUX
gs-4132	24	21	developed	develop	VERB
gs-4132	24	22	to	to	PART
gs-4132	24	23	overcome	overcome	VERB
gs-4132	24	24	these	these	DET
gs-4132	24	25	challenges	challenge	NOUN
gs-4132	24	26	(	(	PUNCT
gs-4132	24	27	peer	peer	NOUN
gs-4132	24	28	et	et	NOUN
gs-4132	24	29	al	al	PROPN
gs-4132	24	30	.	.	PROPN
gs-4132	24	31	,	,	PUNCT
gs-4132	24	32	2007	2007	NUM
gs-4132	24	33	)	)	PUNCT
gs-4132	24	34	.	.	PUNCT
gs-4132	25	1	among	among	ADP
gs-4132	25	2	these	these	DET
gs-4132	25	3	systems	system	NOUN
gs-4132	25	4	,	,	PUNCT
gs-4132	25	5	liposomes	liposome	NOUN
gs-4132	25	6	were	be	AUX
gs-4132	25	7	the	the	DET
gs-4132	25	8	earliest	early	ADJ
gs-4132	25	9	to	to	PART
gs-4132	25	10	achieve	achieve	VERB
gs-4132	25	11	clinical	clinical	ADJ
gs-4132	25	12	approval	approval	NOUN
gs-4132	25	13	,	,	PUNCT
gs-4132	25	14	with	with	ADP
gs-4132	25	15	the	the	DET
gs-4132	25	16	approval	approval	NOUN
gs-4132	25	17	of	of	ADP
gs-4132	25	18	doxil	doxil	ADJ
gs-4132	25	19	®	®	NOUN
gs-4132	25	20	(	(	PUNCT
gs-4132	25	21	liposomal	liposomal	PROPN
gs-4132	25	22	doxorubicin	doxorubicin	PROPN
gs-4132	25	23	)	)	PUNCT
gs-4132	25	24	marking	mark	VERB
gs-4132	25	25	a	a	DET
gs-4132	25	26	breakthrough	breakthrough	NOUN
gs-4132	25	27	in	in	ADP
gs-4132	25	28	nano	nano	NOUN
gs-4132	25	29	-	-	PUNCT
gs-4132	25	30	drug	drug	NOUN
gs-4132	25	31	delivery	delivery	NOUN
gs-4132	25	32	(	(	PUNCT
gs-4132	25	33	barenholz	barenholz	NOUN
gs-4132	25	34	,	,	PUNCT
gs-4132	25	35	2012	2012	NUM
gs-4132	25	36	)	)	PUNCT
gs-4132	25	37	.	.	PUNCT
gs-4132	26	1	more	more	ADV
gs-4132	26	2	recently	recently	ADV
gs-4132	26	3	,	,	PUNCT
gs-4132	26	4	extracellular	extracellular	ADJ
gs-4132	26	5	vesicles	vesicle	NOUN
gs-4132	26	6	(	(	PUNCT
gs-4132	26	7	evs	evs	NOUN
gs-4132	26	8	)	)	PUNCT
gs-4132	26	9	,	,	PUNCT
gs-4132	26	10	including	include	VERB
gs-4132	26	11	exosomes	exosome	NOUN
gs-4132	26	12	and	and	CCONJ
gs-4132	26	13	microvesicles	microvesicle	NOUN
gs-4132	26	14	,	,	PUNCT
gs-4132	26	15	have	have	AUX
gs-4132	26	16	gained	gain	VERB
gs-4132	26	17	attention	attention	NOUN
gs-4132	26	18	as	as	ADP
gs-4132	26	19	natural	natural	ADJ
gs-4132	26	20	nanocarriers	nanocarrier	NOUN
gs-4132	26	21	.	.	PUNCT
gs-4132	27	1	unlike	unlike	ADP
gs-4132	27	2	synthetic	synthetic	ADJ
gs-4132	27	3	vesicles	vesicle	NOUN
gs-4132	27	4	,	,	PUNCT
gs-4132	27	5	evs	evs	NOUN
gs-4132	27	6	are	be	AUX
gs-4132	27	7	actively	actively	ADV
gs-4132	27	8	secreted	secrete	VERB
gs-4132	27	9	by	by	ADP
gs-4132	27	10	cells	cell	NOUN
gs-4132	27	11	and	and	CCONJ
gs-4132	27	12	serve	serve	VERB
gs-4132	27	13	as	as	ADP
gs-4132	27	14	biological	biological	ADJ
gs-4132	27	15	vehicles	vehicle	NOUN
gs-4132	27	16	for	for	ADP
gs-4132	27	17	proteins	protein	NOUN
gs-4132	27	18	,	,	PUNCT
gs-4132	27	19	lipids	lipid	NOUN
gs-4132	27	20	,	,	PUNCT
gs-4132	27	21	and	and	CCONJ
gs-4132	27	22	nucleic	nucleic	ADJ
gs-4132	27	23	acids	acid	NOUN
gs-4132	27	24	(	(	PUNCT
gs-4132	27	25	raposo	raposo	NOUN
gs-4132	27	26	and	and	CCONJ
gs-4132	27	27	stoorvogel	stoorvogel	NOUN
gs-4132	27	28	,	,	PUNCT
gs-4132	27	29	2013	2013	NUM
gs-4132	27	30	)	)	PUNCT
gs-4132	27	31	.	.	PUNCT
gs-4132	28	1	georgian	georgian	NOUN
gs-4132	28	2	scientists/	scientists/	NUM
gs-4132	28	3	.	.	PUNCT
gs-4132	29	1	7	7	NUM
gs-4132	29	2	n	n	DET
gs-4132	29	3	4	4	NUM
gs-4132	29	4	,	,	PUNCT
gs-4132	29	5	2025	2025	NUM
gs-4132	29	6	3	3	NUM
gs-4132	29	7	1.2	1.2	NUM
gs-4132	29	8	from	from	ADP
gs-4132	29	9	artificial	artificial	ADJ
gs-4132	29	10	to	to	ADP
gs-4132	29	11	biological	biological	ADJ
gs-4132	29	12	carriers	carrier	NOUN
gs-4132	29	13	liposomes	liposome	NOUN
gs-4132	29	14	have	have	AUX
gs-4132	29	15	demonstrated	demonstrate	VERB
gs-4132	29	16	advantages	advantage	NOUN
gs-4132	29	17	in	in	ADP
gs-4132	29	18	encapsulating	encapsulate	VERB
gs-4132	29	19	both	both	CCONJ
gs-4132	29	20	hydrophilic	hydrophilic	ADJ
gs-4132	29	21	and	and	CCONJ
gs-4132	29	22	hydrophobic	hydrophobic	NOUN
gs-4132	29	23	molecules	molecule	NOUN
gs-4132	29	24	,	,	PUNCT
gs-4132	29	25	providing	provide	VERB
gs-4132	29	26	controlled	control	VERB
gs-4132	29	27	release	release	NOUN
gs-4132	29	28	,	,	PUNCT
gs-4132	29	29	and	and	CCONJ
gs-4132	29	30	protecting	protect	VERB
gs-4132	29	31	cargo	cargo	NOUN
gs-4132	29	32	from	from	ADP
gs-4132	29	33	degradation	degradation	NOUN
gs-4132	29	34	(	(	PUNCT
gs-4132	29	35	allen	allen	NOUN
gs-4132	29	36	and	and	CCONJ
gs-4132	29	37	cullis	cullis	PROPN
gs-4132	29	38	,	,	PUNCT
gs-4132	29	39	2013	2013	NUM
gs-4132	29	40	)	)	PUNCT
gs-4132	29	41	.	.	PUNCT
gs-4132	30	1	however	however	ADV
gs-4132	30	2	,	,	PUNCT
gs-4132	30	3	they	they	PRON
gs-4132	30	4	often	often	ADV
gs-4132	30	5	require	require	VERB
gs-4132	30	6	surface	surface	NOUN
gs-4132	30	7	modifications	modification	NOUN
gs-4132	30	8	to	to	PART
gs-4132	30	9	evade	evade	VERB
gs-4132	30	10	immune	immune	ADJ
gs-4132	30	11	clearance	clearance	NOUN
gs-4132	30	12	and	and	CCONJ
gs-4132	30	13	achieve	achieve	VERB
gs-4132	30	14	targeted	target	VERB
gs-4132	30	15	delivery	delivery	NOUN
gs-4132	30	16	(	(	PUNCT
gs-4132	30	17	suk	suk	X
gs-4132	30	18	et	et	PROPN
gs-4132	30	19	al	al	PROPN
gs-4132	30	20	.	.	PROPN
gs-4132	30	21	,	,	PUNCT
gs-4132	30	22	2016	2016	NUM
gs-4132	30	23	)	)	PUNCT
gs-4132	30	24	.	.	PUNCT
gs-4132	31	1	exosomes	exosome	NOUN
gs-4132	31	2	,	,	PUNCT
gs-4132	31	3	on	on	ADP
gs-4132	31	4	the	the	DET
gs-4132	31	5	other	other	ADJ
gs-4132	31	6	hand	hand	NOUN
gs-4132	31	7	,	,	PUNCT
gs-4132	31	8	inherently	inherently	ADV
gs-4132	31	9	carry	carry	VERB
gs-4132	31	10	signaling	signal	VERB
gs-4132	31	11	molecules	molecule	NOUN
gs-4132	31	12	and	and	CCONJ
gs-4132	31	13	surface	surface	NOUN
gs-4132	31	14	proteins	protein	NOUN
gs-4132	31	15	that	that	PRON
gs-4132	31	16	mediate	mediate	VERB
gs-4132	31	17	cellspecific	cellspecific	ADJ
gs-4132	31	18	uptake	uptake	NOUN
gs-4132	31	19	,	,	PUNCT
gs-4132	31	20	making	make	VERB
gs-4132	31	21	them	they	PRON
gs-4132	31	22	uniquely	uniquely	ADV
gs-4132	31	23	suited	suited	ADJ
gs-4132	31	24	for	for	ADP
gs-4132	31	25	therapeutic	therapeutic	ADJ
gs-4132	31	26	use	use	NOUN
gs-4132	31	27	(	(	PUNCT
gs-4132	31	28	kalluri	kalluri	NOUN
gs-4132	31	29	and	and	CCONJ
gs-4132	31	30	lebleu	lebleu	PROPN
gs-4132	31	31	,	,	PUNCT
gs-4132	31	32	2020	2020	NUM
gs-4132	31	33	)	)	PUNCT
gs-4132	31	34	.	.	PUNCT
gs-4132	32	1	1.3	1.3	NUM
gs-4132	32	2	scope	scope	NOUN
gs-4132	32	3	of	of	ADP
gs-4132	32	4	this	this	DET
gs-4132	32	5	review	review	NOUN
gs-4132	32	6	this	this	DET
gs-4132	32	7	review	review	NOUN
gs-4132	32	8	will	will	AUX
gs-4132	32	9	compare	compare	VERB
gs-4132	32	10	exosomes	exosome	NOUN
gs-4132	32	11	,	,	PUNCT
gs-4132	32	12	liposomes	liposome	NOUN
gs-4132	32	13	,	,	PUNCT
gs-4132	32	14	and	and	CCONJ
gs-4132	32	15	other	other	ADJ
gs-4132	32	16	small	small	ADJ
gs-4132	32	17	particles	particle	NOUN
gs-4132	32	18	in	in	ADP
gs-4132	32	19	depth	depth	NOUN
gs-4132	32	20	.	.	PUNCT
gs-4132	33	1	we	we	PRON
gs-4132	33	2	will	will	AUX
gs-4132	33	3	first	first	ADV
gs-4132	33	4	explore	explore	VERB
gs-4132	33	5	the	the	DET
gs-4132	33	6	biology	biology	NOUN
gs-4132	33	7	and	and	CCONJ
gs-4132	33	8	therapeutic	therapeutic	ADJ
gs-4132	33	9	potential	potential	NOUN
gs-4132	33	10	of	of	ADP
gs-4132	33	11	exosomes	exosome	NOUN
gs-4132	33	12	,	,	PUNCT
gs-4132	33	13	followed	follow	VERB
gs-4132	33	14	by	by	ADP
gs-4132	33	15	a	a	DET
gs-4132	33	16	discussion	discussion	NOUN
gs-4132	33	17	of	of	ADP
gs-4132	33	18	liposomes	liposome	NOUN
gs-4132	33	19	,	,	PUNCT
gs-4132	33	20	polymeric	polymeric	ADJ
gs-4132	33	21	nanoparticles	nanoparticle	NOUN
gs-4132	33	22	,	,	PUNCT
gs-4132	33	23	and	and	CCONJ
gs-4132	33	24	engineered	engineer	VERB
gs-4132	33	25	ev	ev	NOUN
gs-4132	33	26	-	-	PUNCT
gs-4132	33	27	mimetics	mimetic	NOUN
gs-4132	33	28	.	.	PUNCT
gs-4132	34	1	comparative	comparative	ADJ
gs-4132	34	2	analysis	analysis	NOUN
gs-4132	34	3	will	will	AUX
gs-4132	34	4	then	then	ADV
gs-4132	34	5	highlight	highlight	VERB
gs-4132	34	6	key	key	ADJ
gs-4132	34	7	similarities	similarity	NOUN
gs-4132	34	8	and	and	CCONJ
gs-4132	34	9	differences	difference	NOUN
gs-4132	34	10	in	in	ADP
gs-4132	34	11	design	design	NOUN
gs-4132	34	12	,	,	PUNCT
gs-4132	34	13	safety	safety	NOUN
gs-4132	34	14	,	,	PUNCT
gs-4132	34	15	targeting	targeting	NOUN
gs-4132	34	16	,	,	PUNCT
gs-4132	34	17	and	and	CCONJ
gs-4132	34	18	scalability	scalability	NOUN
gs-4132	34	19	.	.	PUNCT
gs-4132	35	1	finally	finally	ADV
gs-4132	35	2	,	,	PUNCT
gs-4132	35	3	we	we	PRON
gs-4132	35	4	will	will	AUX
gs-4132	35	5	discuss	discuss	VERB
gs-4132	35	6	clinical	clinical	ADJ
gs-4132	35	7	applications	application	NOUN
gs-4132	35	8	,	,	PUNCT
gs-4132	35	9	challenges	challenge	NOUN
gs-4132	35	10	in	in	ADP
gs-4132	35	11	translation	translation	NOUN
gs-4132	35	12	,	,	PUNCT
gs-4132	35	13	and	and	CCONJ
gs-4132	35	14	future	future	ADJ
gs-4132	35	15	perspectives	perspective	NOUN
gs-4132	35	16	.	.	PUNCT
gs-4132	36	1	2	2	X
gs-4132	36	2	.	.	NUM
gs-4132	36	3	exosomes	exosome	NOUN
gs-4132	36	4	:	:	PUNCT
gs-4132	36	5	natural	natural	ADJ
gs-4132	36	6	nanocarriers	nanocarrier	NOUN
gs-4132	36	7	2.1	2.1	NUM
gs-4132	36	8	biogenesis	biogenesis	NOUN
gs-4132	36	9	of	of	ADP
gs-4132	36	10	exosomes	exosome	NOUN
gs-4132	36	11	exosomes	exosome	NOUN
gs-4132	36	12	originate	originate	VERB
gs-4132	36	13	from	from	ADP
gs-4132	36	14	the	the	DET
gs-4132	36	15	endosomal	endosomal	ADJ
gs-4132	36	16	system	system	NOUN
gs-4132	36	17	,	,	PUNCT
gs-4132	36	18	forming	form	VERB
gs-4132	36	19	as	as	ADP
gs-4132	36	20	intraluminal	intraluminal	ADJ
gs-4132	36	21	vesicles	vesicle	NOUN
gs-4132	36	22	within	within	ADP
gs-4132	36	23	multivesicular	multivesicular	ADJ
gs-4132	36	24	bodies	body	NOUN
gs-4132	36	25	(	(	PUNCT
gs-4132	36	26	mvbs	mvbs	PROPN
gs-4132	36	27	)	)	PUNCT
gs-4132	36	28	.	.	PUNCT
gs-4132	37	1	their	their	PRON
gs-4132	37	2	biogenesis	biogenesis	NOUN
gs-4132	37	3	involves	involve	VERB
gs-4132	37	4	both	both	DET
gs-4132	37	5	endosomal	endosomal	ADJ
gs-4132	37	6	sorting	sorting	NOUN
gs-4132	37	7	complex	complex	NOUN
gs-4132	37	8	required	require	VERB
gs-4132	37	9	for	for	ADP
gs-4132	37	10	transport	transport	NOUN
gs-4132	37	11	(	(	PUNCT
gs-4132	37	12	escrt)-dependent	escrt)-dependent	NOUN
gs-4132	37	13	and	and	CCONJ
gs-4132	37	14	escrt	escrt	ADJ
gs-4132	37	15	-	-	PUNCT
gs-4132	37	16	independent	independent	ADJ
gs-4132	37	17	mechanisms	mechanism	NOUN
gs-4132	37	18	(	(	PUNCT
gs-4132	37	19	colombo	colombo	NOUN
gs-4132	37	20	et	et	NOUN
gs-4132	37	21	al	al	PROPN
gs-4132	37	22	.	.	PROPN
gs-4132	37	23	,	,	PUNCT
gs-4132	37	24	2014	2014	NUM
gs-4132	37	25	)	)	PUNCT
gs-4132	37	26	.	.	PUNCT
gs-4132	38	1	escrt	escrt	NUM
gs-4132	38	2	proteins	protein	NOUN
gs-4132	38	3	orchestrate	orchestrate	VERB
gs-4132	38	4	cargo	cargo	NOUN
gs-4132	38	5	sorting	sorting	NOUN
gs-4132	38	6	,	,	PUNCT
gs-4132	38	7	while	while	SCONJ
gs-4132	38	8	escrtindependent	escrtindependent	ADJ
gs-4132	38	9	pathways	pathway	NOUN
gs-4132	38	10	involve	involve	VERB
gs-4132	38	11	lipids	lipid	NOUN
gs-4132	38	12	such	such	ADJ
gs-4132	38	13	as	as	ADP
gs-4132	38	14	ceramide	ceramide	NOUN
gs-4132	38	15	(	(	PUNCT
gs-4132	38	16	trajkovic	trajkovic	NOUN
gs-4132	38	17	et	et	PROPN
gs-4132	38	18	al	al	PROPN
gs-4132	38	19	.	.	PROPN
gs-4132	38	20	,	,	PUNCT
gs-4132	38	21	2008	2008	NUM
gs-4132	38	22	)	)	PUNCT
gs-4132	38	23	.	.	PUNCT
gs-4132	39	1	upon	upon	SCONJ
gs-4132	39	2	fusion	fusion	NOUN
gs-4132	39	3	of	of	ADP
gs-4132	39	4	mvbs	mvbs	NOUN
gs-4132	39	5	with	with	ADP
gs-4132	39	6	the	the	DET
gs-4132	39	7	plasma	plasma	NOUN
gs-4132	39	8	membrane	membrane	NOUN
gs-4132	39	9	,	,	PUNCT
gs-4132	39	10	exosomes	exosome	NOUN
gs-4132	39	11	are	be	AUX
gs-4132	39	12	released	release	VERB
gs-4132	39	13	into	into	ADP
gs-4132	39	14	the	the	DET
gs-4132	39	15	extracellular	extracellular	ADJ
gs-4132	39	16	space	space	NOUN
gs-4132	39	17	.	.	PUNCT
gs-4132	40	1	exosome	exosome	PROPN
gs-4132	40	2	biogenesis	biogenesis	NOUN
gs-4132	40	3	is	be	AUX
gs-4132	40	4	tightly	tightly	ADV
gs-4132	40	5	regulated	regulate	VERB
gs-4132	40	6	by	by	ADP
gs-4132	40	7	rab	rab	PROPN
gs-4132	40	8	family	family	PROPN
gs-4132	40	9	gtpases	gtpase	NOUN
gs-4132	40	10	,	,	PUNCT
gs-4132	40	11	including	include	VERB
gs-4132	40	12	rab27a	rab27a	SYM
gs-4132	40	13	/	/	SYM
gs-4132	40	14	b	b	NOUN
gs-4132	40	15	,	,	PUNCT
gs-4132	40	16	rab11	rab11	NOUN
gs-4132	40	17	,	,	PUNCT
gs-4132	40	18	and	and	CCONJ
gs-4132	40	19	rab35	rab35	VERB
gs-4132	40	20	,	,	PUNCT
gs-4132	40	21	which	which	PRON
gs-4132	40	22	control	control	VERB
gs-4132	40	23	vesicle	vesicle	NOUN
gs-4132	40	24	trafficking	trafficking	NOUN
gs-4132	40	25	and	and	CCONJ
gs-4132	40	26	secretion	secretion	NOUN
gs-4132	40	27	(	(	PUNCT
gs-4132	40	28	ostrowski	ostrowski	NOUN
gs-4132	40	29	et	et	PROPN
gs-4132	40	30	al	al	PROPN
gs-4132	40	31	.	.	PROPN
gs-4132	40	32	,	,	PUNCT
gs-4132	40	33	2010	2010	NUM
gs-4132	40	34	)	)	PUNCT
gs-4132	40	35	.	.	PUNCT
gs-4132	41	1	their	their	PRON
gs-4132	41	2	release	release	NOUN
gs-4132	41	3	is	be	AUX
gs-4132	41	4	influenced	influence	VERB
gs-4132	41	5	by	by	ADP
gs-4132	41	6	cellular	cellular	ADJ
gs-4132	41	7	conditions	condition	NOUN
gs-4132	41	8	such	such	ADJ
gs-4132	41	9	as	as	ADP
gs-4132	41	10	hypoxia	hypoxia	NOUN
gs-4132	41	11	,	,	PUNCT
gs-4132	41	12	stress	stress	NOUN
gs-4132	41	13	,	,	PUNCT
gs-4132	41	14	and	and	CCONJ
gs-4132	41	15	inflammation	inflammation	NOUN
gs-4132	41	16	,	,	PUNCT
gs-4132	41	17	which	which	PRON
gs-4132	41	18	alter	alter	VERB
gs-4132	41	19	exosome	exosome	PROPN
gs-4132	41	20	cargo	cargo	PROPN
gs-4132	41	21	and	and	CCONJ
gs-4132	41	22	function	function	NOUN
gs-4132	41	23	(	(	PUNCT
gs-4132	41	24	king	king	NOUN
gs-4132	41	25	et	et	PROPN
gs-4132	41	26	al	al	PROPN
gs-4132	41	27	.	.	PROPN
gs-4132	41	28	,	,	PUNCT
gs-4132	41	29	2012	2012	NUM
gs-4132	41	30	)	)	PUNCT
gs-4132	41	31	.	.	PUNCT
gs-4132	42	1	2.2	2.2	NUM
gs-4132	42	2	structure	structure	NOUN
gs-4132	42	3	and	and	CCONJ
gs-4132	42	4	composition	composition	NOUN
gs-4132	42	5	exosomes	exosome	NOUN
gs-4132	42	6	are	be	AUX
gs-4132	42	7	30–150	30–150	NUM
gs-4132	42	8	nm	nm	ADJ
gs-4132	42	9	lipid	lipid	NOUN
gs-4132	42	10	bilayer	bilayer	NOUN
gs-4132	42	11	vesicles	vesicle	NOUN
gs-4132	42	12	,	,	PUNCT
gs-4132	42	13	enriched	enrich	VERB
gs-4132	42	14	in	in	ADP
gs-4132	42	15	cholesterol	cholesterol	NOUN
gs-4132	42	16	,	,	PUNCT
gs-4132	42	17	sphingomyelin	sphingomyelin	NOUN
gs-4132	42	18	,	,	PUNCT
gs-4132	42	19	and	and	CCONJ
gs-4132	42	20	phosphatidylserine	phosphatidylserine	NOUN
gs-4132	42	21	.	.	PUNCT
gs-4132	43	1	their	their	PRON
gs-4132	43	2	surface	surface	NOUN
gs-4132	43	3	is	be	AUX
gs-4132	43	4	decorated	decorate	VERB
gs-4132	43	5	with	with	ADP
gs-4132	43	6	tetraspanins	tetraspanin	NOUN
gs-4132	43	7	(	(	PUNCT
gs-4132	43	8	cd9	cd9	NOUN
gs-4132	43	9	,	,	PUNCT
gs-4132	43	10	cd63	cd63	PROPN
gs-4132	43	11	,	,	PUNCT
gs-4132	43	12	cd81	cd81	PROPN
gs-4132	43	13	)	)	PUNCT
gs-4132	43	14	,	,	PUNCT
gs-4132	43	15	integrins	integrin	VERB
gs-4132	43	16	,	,	PUNCT
gs-4132	43	17	and	and	CCONJ
gs-4132	43	18	major	major	ADJ
gs-4132	43	19	histocompatibility	histocompatibility	NOUN
gs-4132	43	20	complex	complex	NOUN
gs-4132	43	21	(	(	PUNCT
gs-4132	43	22	mhc	mhc	NOUN
gs-4132	43	23	)	)	PUNCT
gs-4132	43	24	molecules	molecule	NOUN
gs-4132	43	25	(	(	PUNCT
gs-4132	43	26	théry	théry	NOUN
gs-4132	43	27	et	et	PROPN
gs-4132	43	28	al	al	PROPN
gs-4132	43	29	.	.	PROPN
gs-4132	43	30	,	,	PUNCT
gs-4132	43	31	2009	2009	NUM
gs-4132	43	32	)	)	PUNCT
gs-4132	43	33	.	.	PUNCT
gs-4132	44	1	the	the	DET
gs-4132	44	2	cargo	cargo	NOUN
gs-4132	44	3	includes	include	VERB
gs-4132	44	4	:	:	PUNCT
gs-4132	44	5	proteins	protein	NOUN
gs-4132	44	6	:	:	PUNCT
gs-4132	44	7	signaling	signal	VERB
gs-4132	44	8	molecules	molecule	NOUN
gs-4132	44	9	,	,	PUNCT
gs-4132	44	10	enzymes	enzyme	NOUN
gs-4132	44	11	,	,	PUNCT
gs-4132	44	12	heat	heat	NOUN
gs-4132	44	13	shock	shock	NOUN
gs-4132	44	14	proteins	protein	NOUN
gs-4132	44	15	.	.	PUNCT
gs-4132	45	1	lipids	lipid	NOUN
gs-4132	45	2	:	:	PUNCT
gs-4132	45	3	sphingolipids	sphingolipid	NOUN
gs-4132	45	4	,	,	PUNCT
gs-4132	45	5	ceramides	ceramide	NOUN
gs-4132	45	6	,	,	PUNCT
gs-4132	45	7	cholesterol	cholesterol	NOUN
gs-4132	45	8	.	.	PUNCT
gs-4132	46	1	georgian	georgian	NOUN
gs-4132	46	2	scientists/	scientists/	NUM
gs-4132	46	3	.	.	PUNCT
gs-4132	47	1	7	7	NUM
gs-4132	47	2	n	n	DET
gs-4132	47	3	4	4	NUM
gs-4132	47	4	,	,	PUNCT
gs-4132	47	5	2025	2025	NUM
gs-4132	47	6	4	4	NUM
gs-4132	47	7	nucleic	nucleic	ADJ
gs-4132	47	8	acids	acid	NOUN
gs-4132	47	9	:	:	PUNCT
gs-4132	47	10	mrnas	mrna	NOUN
gs-4132	47	11	,	,	PUNCT
gs-4132	47	12	micrornas	microrna	NOUN
gs-4132	47	13	,	,	PUNCT
gs-4132	47	14	long	long	ADJ
gs-4132	47	15	noncoding	noncoding	ADJ
gs-4132	47	16	rnas	rna	NOUN
gs-4132	47	17	,	,	PUNCT
gs-4132	47	18	dna	dna	NOUN
gs-4132	47	19	fragments	fragment	NOUN
gs-4132	47	20	(	(	PUNCT
gs-4132	47	21	valadi	valadi	NOUN
gs-4132	47	22	et	et	PROPN
gs-4132	47	23	al	al	PROPN
gs-4132	47	24	.	.	PROPN
gs-4132	47	25	,	,	PUNCT
gs-4132	47	26	2007	2007	NUM
gs-4132	47	27	)	)	PUNCT
gs-4132	47	28	.	.	PUNCT
gs-4132	48	1	this	this	DET
gs-4132	48	2	composition	composition	NOUN
gs-4132	48	3	reflects	reflect	VERB
gs-4132	48	4	the	the	DET
gs-4132	48	5	parental	parental	ADJ
gs-4132	48	6	cell	cell	NOUN
gs-4132	48	7	type	type	NOUN
gs-4132	48	8	and	and	CCONJ
gs-4132	48	9	microenvironment	microenvironment	NOUN
gs-4132	48	10	,	,	PUNCT
gs-4132	48	11	enabling	enable	VERB
gs-4132	48	12	exosomes	exosome	NOUN
gs-4132	48	13	to	to	PART
gs-4132	48	14	act	act	VERB
gs-4132	48	15	as	as	ADP
gs-4132	48	16	“	"	PUNCT
gs-4132	48	17	molecular	molecular	ADJ
gs-4132	48	18	fingerprints	fingerprint	NOUN
gs-4132	48	19	”	"	PUNCT
gs-4132	48	20	of	of	ADP
gs-4132	48	21	their	their	PRON
gs-4132	48	22	cells	cell	NOUN
gs-4132	48	23	of	of	ADP
gs-4132	48	24	origin	origin	NOUN
gs-4132	48	25	.	.	PUNCT
gs-4132	49	1	2.3	2.3	NUM
gs-4132	49	2	physiological	physiological	ADJ
gs-4132	49	3	functions	function	NOUN
gs-4132	49	4	of	of	ADP
gs-4132	49	5	exosomes	exosome	NOUN
gs-4132	49	6	exosomes	exosome	NOUN
gs-4132	49	7	mediate	mediate	VERB
gs-4132	49	8	cell	cell	NOUN
gs-4132	49	9	-	-	PUNCT
gs-4132	49	10	to	to	ADP
gs-4132	49	11	-	-	PUNCT
gs-4132	49	12	cell	cell	NOUN
gs-4132	49	13	communication	communication	NOUN
gs-4132	49	14	by	by	ADP
gs-4132	49	15	transferring	transfer	VERB
gs-4132	49	16	their	their	PRON
gs-4132	49	17	cargo	cargo	NOUN
gs-4132	49	18	to	to	PART
gs-4132	49	19	recipient	recipient	NOUN
gs-4132	49	20	cells	cell	NOUN
gs-4132	49	21	,	,	PUNCT
gs-4132	49	22	influencing	influence	VERB
gs-4132	49	23	gene	gene	NOUN
gs-4132	49	24	expression	expression	NOUN
gs-4132	49	25	and	and	CCONJ
gs-4132	49	26	cellular	cellular	ADJ
gs-4132	49	27	behavior	behavior	NOUN
gs-4132	49	28	(	(	PUNCT
gs-4132	49	29	raposo	raposo	NOUN
gs-4132	49	30	and	and	CCONJ
gs-4132	49	31	stoorvogel	stoorvogel	NOUN
gs-4132	49	32	,	,	PUNCT
gs-4132	49	33	2013	2013	NUM
gs-4132	49	34	)	)	PUNCT
gs-4132	49	35	.	.	PUNCT
gs-4132	50	1	immune	immune	ADJ
gs-4132	50	2	regulation	regulation	NOUN
gs-4132	50	3	:	:	PUNCT
gs-4132	50	4	dendritic	dendritic	ADJ
gs-4132	50	5	cell	cell	NOUN
gs-4132	50	6	-	-	PUNCT
gs-4132	50	7	derived	derive	VERB
gs-4132	50	8	exosomes	exosome	NOUN
gs-4132	50	9	can	can	AUX
gs-4132	50	10	present	present	VERB
gs-4132	50	11	antigens	antigen	NOUN
gs-4132	50	12	and	and	CCONJ
gs-4132	50	13	modulate	modulate	VERB
gs-4132	50	14	t	t	NOUN
gs-4132	50	15	-	-	PUNCT
gs-4132	50	16	cell	cell	NOUN
gs-4132	50	17	responses	response	NOUN
gs-4132	50	18	(	(	PUNCT
gs-4132	50	19	théry	théry	NOUN
gs-4132	50	20	et	et	PROPN
gs-4132	50	21	al	al	PROPN
gs-4132	50	22	.	.	PROPN
gs-4132	50	23	,	,	PUNCT
gs-4132	50	24	2002	2002	NUM
gs-4132	50	25	)	)	PUNCT
gs-4132	50	26	.	.	PUNCT
gs-4132	51	1	tumor	tumor	NOUN
gs-4132	51	2	-	-	PUNCT
gs-4132	51	3	derived	derive	VERB
gs-4132	51	4	exosomes	exosome	NOUN
gs-4132	51	5	suppress	suppress	VERB
gs-4132	51	6	antitumor	antitumor	PROPN
gs-4132	51	7	immunity	immunity	NOUN
gs-4132	51	8	by	by	ADP
gs-4132	51	9	carrying	carry	VERB
gs-4132	51	10	pd	pd	NOUN
gs-4132	51	11	-	-	PROPN
gs-4132	51	12	l1	l1	PROPN
gs-4132	51	13	(	(	PUNCT
gs-4132	51	14	chen	chen	PROPN
gs-4132	51	15	et	et	PROPN
gs-4132	51	16	al	al	PROPN
gs-4132	51	17	.	.	PROPN
gs-4132	51	18	,	,	PUNCT
gs-4132	51	19	2018	2018	NUM
gs-4132	51	20	)	)	PUNCT
gs-4132	51	21	.	.	PUNCT
gs-4132	52	1	neural	neural	ADJ
gs-4132	52	2	communication	communication	NOUN
gs-4132	52	3	:	:	PUNCT
gs-4132	52	4	exosomes	exosome	NOUN
gs-4132	52	5	from	from	ADP
gs-4132	52	6	neurons	neuron	NOUN
gs-4132	52	7	and	and	CCONJ
gs-4132	52	8	glia	glia	NOUN
gs-4132	52	9	regulate	regulate	VERB
gs-4132	52	10	synaptic	synaptic	ADJ
gs-4132	52	11	activity	activity	NOUN
gs-4132	52	12	,	,	PUNCT
gs-4132	52	13	neurogenesis	neurogenesis	NOUN
gs-4132	52	14	,	,	PUNCT
gs-4132	52	15	and	and	CCONJ
gs-4132	52	16	propagation	propagation	NOUN
gs-4132	52	17	of	of	ADP
gs-4132	52	18	misfolded	misfolde	VERB
gs-4132	52	19	proteins	protein	NOUN
gs-4132	52	20	such	such	ADJ
gs-4132	52	21	as	as	ADP
gs-4132	52	22	-synuclein	-synuclein	ADJ
gs-4132	52	23	and	and	CCONJ
gs-4132	52	24	tau	tau	PROPN
gs-4132	52	25	(	(	PUNCT
gs-4132	52	26	quek	quek	PROPN
gs-4132	52	27	and	and	CCONJ
gs-4132	52	28	hill	hill	PROPN
gs-4132	52	29	,	,	PUNCT
gs-4132	52	30	2017	2017	NUM
gs-4132	52	31	)	)	PUNCT
gs-4132	52	32	.	.	PUNCT
gs-4132	53	1	tissue	tissue	NOUN
gs-4132	53	2	repair	repair	NOUN
gs-4132	53	3	:	:	PUNCT
gs-4132	53	4	mesenchymal	mesenchymal	ADJ
gs-4132	53	5	stem	stem	NOUN
gs-4132	53	6	cell	cell	NOUN
gs-4132	53	7	(	(	PUNCT
gs-4132	53	8	msc)-derived	msc)-derive	VERB
gs-4132	53	9	exosomes	exosome	NOUN
gs-4132	53	10	promote	promote	VERB
gs-4132	53	11	angiogenesis	angiogenesis	NOUN
gs-4132	53	12	and	and	CCONJ
gs-4132	53	13	suppress	suppress	VERB
gs-4132	53	14	inflammation	inflammation	NOUN
gs-4132	53	15	,	,	PUNCT
gs-4132	53	16	accelerating	accelerate	VERB
gs-4132	53	17	wound	wound	ADJ
gs-4132	53	18	healing	healing	NOUN
gs-4132	53	19	(	(	PUNCT
gs-4132	53	20	phinney	phinney	NOUN
gs-4132	53	21	and	and	CCONJ
gs-4132	53	22	pittenger	pittenger	PROPN
gs-4132	53	23	,	,	PUNCT
gs-4132	53	24	2017	2017	NUM
gs-4132	53	25	)	)	PUNCT
gs-4132	53	26	.	.	PUNCT
gs-4132	54	1	2.4	2.4	NUM
gs-4132	54	2	exosomes	exosome	NOUN
gs-4132	54	3	in	in	ADP
gs-4132	54	4	disease	disease	NOUN
gs-4132	54	5	pathophysiology	pathophysiology	NOUN
gs-4132	54	6	exosomes	exosome	NOUN
gs-4132	54	7	are	be	AUX
gs-4132	54	8	implicated	implicate	VERB
gs-4132	54	9	in	in	ADP
gs-4132	54	10	multiple	multiple	ADJ
gs-4132	54	11	disease	disease	NOUN
gs-4132	54	12	processes	process	NOUN
gs-4132	54	13	:	:	PUNCT
gs-4132	54	14	cancer	cancer	NOUN
gs-4132	54	15	:	:	PUNCT
gs-4132	54	16	promote	promote	VERB
gs-4132	54	17	metastasis	metastasis	NOUN
gs-4132	54	18	,	,	PUNCT
gs-4132	54	19	drug	drug	NOUN
gs-4132	54	20	resistance	resistance	NOUN
gs-4132	54	21	,	,	PUNCT
gs-4132	54	22	and	and	CCONJ
gs-4132	54	23	angiogenesis	angiogenesis	NOUN
gs-4132	54	24	(	(	PUNCT
gs-4132	54	25	kalluri	kalluri	PROPN
gs-4132	54	26	and	and	CCONJ
gs-4132	54	27	lebleu	lebleu	PROPN
gs-4132	54	28	,	,	PUNCT
gs-4132	54	29	2020	2020	NUM
gs-4132	54	30	)	)	PUNCT
gs-4132	54	31	.	.	PUNCT
gs-4132	55	1	neurodegeneration	neurodegeneration	NOUN
gs-4132	55	2	:	:	PUNCT
gs-4132	55	3	spread	spread	VERB
gs-4132	55	4	pathogenic	pathogenic	ADJ
gs-4132	55	5	proteins	protein	NOUN
gs-4132	55	6	such	such	ADJ
gs-4132	55	7	as	as	ADP
gs-4132	55	8	amyloid	amyloid	NOUN
gs-4132	55	9	and	and	CCONJ
gs-4132	55	10	tau	tau	PROPN
gs-4132	55	11	in	in	ADP
gs-4132	55	12	alzheimer	alzheimer	PROPN
gs-4132	55	13	’s	’s	PART
gs-4132	55	14	disease	disease	NOUN
gs-4132	55	15	(	(	PUNCT
gs-4132	55	16	rajendran	rajendran	PROPN
gs-4132	55	17	et	et	PROPN
gs-4132	55	18	al	al	PROPN
gs-4132	55	19	.	.	PROPN
gs-4132	55	20	,	,	PUNCT
gs-4132	55	21	2006	2006	NUM
gs-4132	55	22	)	)	PUNCT
gs-4132	55	23	.	.	PUNCT
gs-4132	56	1	cardiovascular	cardiovascular	ADJ
gs-4132	56	2	disease	disease	NOUN
gs-4132	56	3	:	:	PUNCT
gs-4132	56	4	contribute	contribute	VERB
gs-4132	56	5	to	to	ADP
gs-4132	56	6	endothelial	endothelial	ADJ
gs-4132	56	7	dysfunction	dysfunction	NOUN
gs-4132	56	8	and	and	CCONJ
gs-4132	56	9	atherosclerosis	atherosclerosis	NOUN
gs-4132	56	10	(	(	PUNCT
gs-4132	56	11	vicencio	vicencio	NOUN
gs-4132	56	12	et	et	PROPN
gs-4132	56	13	al	al	PROPN
gs-4132	56	14	.	.	PROPN
gs-4132	56	15	,	,	PUNCT
gs-4132	56	16	2015	2015	NUM
gs-4132	56	17	)	)	PUNCT
gs-4132	56	18	.	.	PUNCT
gs-4132	57	1	these	these	DET
gs-4132	57	2	features	feature	NOUN
gs-4132	57	3	also	also	ADV
gs-4132	57	4	make	make	VERB
gs-4132	57	5	them	they	PRON
gs-4132	57	6	potential	potential	ADJ
gs-4132	57	7	diagnostic	diagnostic	ADJ
gs-4132	57	8	biomarkers	biomarker	NOUN
gs-4132	57	9	,	,	PUNCT
gs-4132	57	10	as	as	ADP
gs-4132	57	11	exosomes	exosome	NOUN
gs-4132	57	12	isolated	isolate	VERB
gs-4132	57	13	from	from	ADP
gs-4132	57	14	blood	blood	NOUN
gs-4132	57	15	,	,	PUNCT
gs-4132	57	16	urine	urine	NOUN
gs-4132	57	17	,	,	PUNCT
gs-4132	57	18	or	or	CCONJ
gs-4132	57	19	cerebrospinal	cerebrospinal	ADJ
gs-4132	57	20	fluid	fluid	NOUN
gs-4132	57	21	reflect	reflect	NOUN
gs-4132	57	22	disease	disease	NOUN
gs-4132	57	23	states	state	NOUN
gs-4132	57	24	.	.	PUNCT
gs-4132	58	1	figure	figure	VERB
gs-4132	58	2	1	1	NUM
gs-4132	58	3	.	.	PUNCT
gs-4132	58	4	comparative	comparative	ADJ
gs-4132	58	5	drug	drug	NOUN
gs-4132	58	6	loading	loading	NOUN
gs-4132	58	7	efficiency	efficiency	NOUN
gs-4132	58	8	of	of	ADP
gs-4132	58	9	nanoparticles	nanoparticle	NOUN
gs-4132	58	10	.	.	PUNCT
gs-4132	59	1	bar	bar	NOUN
gs-4132	59	2	graph	graph	NOUN
gs-4132	59	3	comparing	compare	VERB
gs-4132	59	4	drug	drug	NOUN
gs-4132	59	5	loading	loading	NOUN
gs-4132	59	6	efficiency	efficiency	NOUN
gs-4132	59	7	(	(	PUNCT
gs-4132	59	8	%	%	INTJ
gs-4132	59	9	)	)	PUNCT
gs-4132	59	10	of	of	ADP
gs-4132	59	11	exosomes	exosome	NOUN
gs-4132	59	12	,	,	PUNCT
gs-4132	59	13	liposomes	liposome	NOUN
gs-4132	59	14	,	,	PUNCT
gs-4132	59	15	and	and	CCONJ
gs-4132	59	16	polymeric	polymeric	ADJ
gs-4132	59	17	nanoparticles	nanoparticle	NOUN
gs-4132	59	18	.	.	PUNCT
gs-4132	60	1	data	datum	NOUN
gs-4132	60	2	are	be	AUX
gs-4132	60	3	presented	present	VERB
gs-4132	60	4	as	as	ADP
gs-4132	60	5	mean	mean	NOUN
gs-4132	60	6	±	±	NUM
gs-4132	60	7	sd	sd	NOUN
gs-4132	60	8	from	from	ADP
gs-4132	60	9	simulated	simulate	VERB
gs-4132	60	10	replicates	replicate	NOUN
gs-4132	60	11	(	(	PUNCT
gs-4132	60	12	n=20	n=20	NOUN
gs-4132	60	13	per	per	ADP
gs-4132	60	14	group	group	NOUN
gs-4132	60	15	)	)	PUNCT
gs-4132	60	16	.	.	PUNCT
gs-4132	61	1	pairwise	pairwise	NOUN
gs-4132	61	2	comparisons	comparison	NOUN
gs-4132	61	3	were	be	AUX
gs-4132	61	4	performed	perform	VERB
gs-4132	61	5	using	use	VERB
gs-4132	61	6	independent	independent	ADJ
gs-4132	61	7	t	t	NOUN
gs-4132	61	8	-	-	PUNCT
gs-4132	61	9	tests	test	NOUN
gs-4132	61	10	,	,	PUNCT
gs-4132	61	11	with	with	ADP
gs-4132	61	12	significance	significance	NOUN
gs-4132	61	13	levels	level	NOUN
gs-4132	61	14	indicated	indicate	VERB
gs-4132	61	15	above	above	ADP
gs-4132	61	16	bars	bar	NOUN
gs-4132	61	17	.	.	PUNCT
gs-4132	62	1	liposomes	liposome	NOUN
gs-4132	62	2	demonstrated	demonstrate	VERB
gs-4132	62	3	the	the	DET
gs-4132	62	4	highest	high	ADJ
gs-4132	62	5	drug	drug	NOUN
gs-4132	62	6	loading	loading	NOUN
gs-4132	62	7	efficiency	efficiency	NOUN
gs-4132	62	8	,	,	PUNCT
gs-4132	62	9	followed	follow	VERB
gs-4132	62	10	by	by	ADP
gs-4132	62	11	polymeric	polymeric	ADJ
gs-4132	62	12	nanoparticles	nanoparticle	NOUN
gs-4132	62	13	,	,	PUNCT
gs-4132	62	14	whereas	whereas	SCONJ
gs-4132	62	15	exosomes	exosome	NOUN
gs-4132	62	16	exhibited	exhibit	VERB
gs-4132	62	17	lower	low	ADJ
gs-4132	62	18	but	but	CCONJ
gs-4132	62	19	biologically	biologically	ADV
gs-4132	62	20	relevant	relevant	ADJ
gs-4132	62	21	loading	loading	NOUN
gs-4132	62	22	capacity	capacity	NOUN
gs-4132	62	23	.	.	PUNCT
gs-4132	63	1	statistical	statistical	ADJ
gs-4132	63	2	differences	difference	NOUN
gs-4132	63	3	are	be	AUX
gs-4132	63	4	annotated	annotate	VERB
gs-4132	63	5	as	as	ADP
gs-4132	63	6	exact	exact	ADJ
gs-4132	63	7	p	p	NOUN
gs-4132	63	8	values	value	NOUN
gs-4132	63	9	,	,	PUNCT
gs-4132	63	10	with	with	ADP
gs-4132	63	11	p	p	X
gs-4132	63	12	<	<	X
gs-4132	63	13	0.001	0.001	NUM
gs-4132	63	14	for	for	ADP
gs-4132	63	15	highly	highly	ADV
gs-4132	63	16	significant	significant	ADJ
gs-4132	63	17	differences	difference	NOUN
gs-4132	63	18	.	.	PUNCT
gs-4132	64	1	georgian	georgian	NOUN
gs-4132	64	2	scientists/	scientists/	NUM
gs-4132	64	3	.	.	PUNCT
gs-4132	65	1	7	7	NUM
gs-4132	65	2	n	n	DET
gs-4132	65	3	4	4	NUM
gs-4132	65	4	,	,	PUNCT
gs-4132	65	5	2025	2025	NUM
gs-4132	65	6	5	5	NUM
gs-4132	65	7	3	3	NUM
gs-4132	65	8	.	.	PUNCT
gs-4132	65	9	other	other	ADJ
gs-4132	65	10	extracellular	extracellular	ADJ
gs-4132	65	11	vesicles	vesicle	NOUN
gs-4132	65	12	and	and	CCONJ
gs-4132	65	13	natural	natural	ADJ
gs-4132	65	14	nanoparticles	nanoparticle	NOUN
gs-4132	65	15	3.1	3.1	NUM
gs-4132	65	16	microvesicles	microvesicle	NOUN
gs-4132	65	17	and	and	CCONJ
gs-4132	65	18	apoptotic	apoptotic	ADJ
gs-4132	65	19	bodies	body	NOUN
gs-4132	65	20	while	while	SCONJ
gs-4132	65	21	exosomes	exosome	NOUN
gs-4132	65	22	are	be	AUX
gs-4132	65	23	defined	define	VERB
gs-4132	65	24	as	as	ADP
gs-4132	65	25	30–150	30–150	NUM
gs-4132	65	26	nm	nm	ADJ
gs-4132	65	27	vesicles	vesicle	NOUN
gs-4132	65	28	of	of	ADP
gs-4132	65	29	endosomal	endosomal	ADJ
gs-4132	65	30	origin	origin	NOUN
gs-4132	65	31	,	,	PUNCT
gs-4132	65	32	cells	cell	NOUN
gs-4132	65	33	release	release	VERB
gs-4132	65	34	a	a	DET
gs-4132	65	35	broader	broad	ADJ
gs-4132	65	36	spectrum	spectrum	NOUN
gs-4132	65	37	of	of	ADP
gs-4132	65	38	extracellular	extracellular	ADJ
gs-4132	65	39	vesicles	vesicle	NOUN
gs-4132	65	40	(	(	PUNCT
gs-4132	65	41	evs	evs	NOUN
gs-4132	65	42	)	)	PUNCT
gs-4132	65	43	.	.	PUNCT
gs-4132	66	1	microvesicles	microvesicle	NOUN
gs-4132	66	2	(	(	PUNCT
gs-4132	66	3	also	also	ADV
gs-4132	66	4	called	call	VERB
gs-4132	66	5	microparticles	microparticle	NOUN
gs-4132	66	6	or	or	CCONJ
gs-4132	66	7	ectosomes	ectosome	NOUN
gs-4132	66	8	)	)	PUNCT
gs-4132	66	9	are	be	AUX
gs-4132	66	10	larger	large	ADJ
gs-4132	66	11	vesicles	vesicle	NOUN
gs-4132	66	12	(	(	PUNCT
gs-4132	66	13	100–1000	100–1000	NUM
gs-4132	66	14	nm	nm	NOUN
gs-4132	66	15	)	)	PUNCT
gs-4132	66	16	shed	shed	VERB
gs-4132	66	17	directly	directly	ADV
gs-4132	66	18	from	from	ADP
gs-4132	66	19	the	the	DET
gs-4132	66	20	plasma	plasma	NOUN
gs-4132	66	21	membrane	membrane	NOUN
gs-4132	66	22	through	through	ADP
gs-4132	66	23	outward	outward	ADJ
gs-4132	66	24	budding	bud	VERB
gs-4132	66	25	(	(	PUNCT
gs-4132	66	26	cocucci	cocucci	NOUN
gs-4132	66	27	and	and	CCONJ
gs-4132	66	28	meldolesi	meldolesi	PROPN
gs-4132	66	29	,	,	PUNCT
gs-4132	66	30	2015	2015	NUM
gs-4132	66	31	)	)	PUNCT
gs-4132	66	32	.	.	PUNCT
gs-4132	67	1	they	they	PRON
gs-4132	67	2	carry	carry	VERB
gs-4132	67	3	membrane	membrane	NOUN
gs-4132	67	4	proteins	protein	NOUN
gs-4132	67	5	,	,	PUNCT
gs-4132	67	6	cytosolic	cytosolic	ADJ
gs-4132	67	7	enzymes	enzyme	NOUN
gs-4132	67	8	,	,	PUNCT
gs-4132	67	9	and	and	CCONJ
gs-4132	67	10	nucleic	nucleic	ADJ
gs-4132	67	11	acids	acid	NOUN
gs-4132	67	12	,	,	PUNCT
gs-4132	67	13	playing	play	VERB
gs-4132	67	14	important	important	ADJ
gs-4132	67	15	roles	role	NOUN
gs-4132	67	16	in	in	ADP
gs-4132	67	17	coagulation	coagulation	NOUN
gs-4132	67	18	,	,	PUNCT
gs-4132	67	19	inflammation	inflammation	NOUN
gs-4132	67	20	,	,	PUNCT
gs-4132	67	21	and	and	CCONJ
gs-4132	67	22	cancer	cancer	NOUN
gs-4132	67	23	progression	progression	NOUN
gs-4132	67	24	(	(	PUNCT
gs-4132	67	25	györgy	györgy	NOUN
gs-4132	67	26	et	et	PROPN
gs-4132	67	27	al	al	PROPN
gs-4132	67	28	.	.	PROPN
gs-4132	67	29	,	,	PUNCT
gs-4132	67	30	2011	2011	NUM
gs-4132	67	31	)	)	PUNCT
gs-4132	67	32	.	.	PUNCT
gs-4132	68	1	apoptotic	apoptotic	ADJ
gs-4132	68	2	bodies	body	NOUN
gs-4132	68	3	are	be	AUX
gs-4132	68	4	even	even	ADV
gs-4132	68	5	larger	large	ADJ
gs-4132	68	6	vesicles	vesicle	NOUN
gs-4132	68	7	(	(	PUNCT
gs-4132	68	8	500–2000	500–2000	NUM
gs-4132	68	9	nm	nm	NOUN
gs-4132	68	10	)	)	PUNCT
gs-4132	68	11	generated	generate	VERB
gs-4132	68	12	during	during	ADP
gs-4132	68	13	programmed	program	VERB
gs-4132	68	14	cell	cell	NOUN
gs-4132	68	15	death	death	NOUN
gs-4132	68	16	.	.	PUNCT
gs-4132	69	1	they	they	PRON
gs-4132	69	2	package	package	VERB
gs-4132	69	3	cellular	cellular	ADJ
gs-4132	69	4	contents	content	NOUN
gs-4132	69	5	,	,	PUNCT
gs-4132	69	6	including	include	VERB
gs-4132	69	7	organelles	organelle	NOUN
gs-4132	69	8	and	and	CCONJ
gs-4132	69	9	nuclear	nuclear	ADJ
gs-4132	69	10	fragments	fragment	NOUN
gs-4132	69	11	,	,	PUNCT
gs-4132	69	12	and	and	CCONJ
gs-4132	69	13	facilitate	facilitate	NOUN
gs-4132	69	14	clearance	clearance	NOUN
gs-4132	69	15	by	by	ADP
gs-4132	69	16	phagocytes	phagocyte	NOUN
gs-4132	69	17	(	(	PUNCT
gs-4132	69	18	kerr	kerr	PROPN
gs-4132	69	19	et	et	PROPN
gs-4132	69	20	al	al	PROPN
gs-4132	69	21	.	.	PROPN
gs-4132	69	22	,	,	PUNCT
gs-4132	69	23	1972	1972	NUM
gs-4132	69	24	)	)	PUNCT
gs-4132	69	25	.	.	PUNCT
gs-4132	70	1	though	though	SCONJ
gs-4132	70	2	less	less	ADV
gs-4132	70	3	commonly	commonly	ADV
gs-4132	70	4	investigated	investigate	VERB
gs-4132	70	5	for	for	ADP
gs-4132	70	6	therapeutic	therapeutic	ADJ
gs-4132	70	7	purposes	purpose	NOUN
gs-4132	70	8	,	,	PUNCT
gs-4132	70	9	apoptotic	apoptotic	ADJ
gs-4132	70	10	bodies	body	NOUN
gs-4132	70	11	contribute	contribute	VERB
gs-4132	70	12	to	to	ADP
gs-4132	70	13	immune	immune	ADJ
gs-4132	70	14	tolerance	tolerance	NOUN
gs-4132	70	15	and	and	CCONJ
gs-4132	70	16	tissue	tissue	NOUN
gs-4132	70	17	remodeling	remodeling	NOUN
gs-4132	70	18	(	(	PUNCT
gs-4132	70	19	atkin	atkin	PROPN
gs-4132	70	20	-	-	PUNCT
gs-4132	70	21	smith	smith	PROPN
gs-4132	70	22	and	and	CCONJ
gs-4132	70	23	poon	poon	NOUN
gs-4132	70	24	,	,	PUNCT
gs-4132	70	25	2017	2017	NUM
gs-4132	70	26	)	)	PUNCT
gs-4132	70	27	.	.	PUNCT
gs-4132	71	1	georgian	georgian	NOUN
gs-4132	71	2	scientists/	scientists/	NUM
gs-4132	71	3	.	.	PUNCT
gs-4132	72	1	7	7	NUM
gs-4132	72	2	n	n	DET
gs-4132	72	3	4	4	NUM
gs-4132	72	4	,	,	PUNCT
gs-4132	72	5	2025	2025	NUM
gs-4132	72	6	6	6	NUM
gs-4132	72	7	3.2	3.2	NUM
gs-4132	72	8	biological	biological	ADJ
gs-4132	72	9	similarities	similarity	NOUN
gs-4132	72	10	and	and	CCONJ
gs-4132	72	11	differences	difference	NOUN
gs-4132	72	12	with	with	ADP
gs-4132	72	13	exosomes	exosome	NOUN
gs-4132	72	14	compared	compare	VERB
gs-4132	72	15	to	to	ADP
gs-4132	72	16	exosomes	exosome	NOUN
gs-4132	72	17	,	,	PUNCT
gs-4132	72	18	microvesicles	microvesicle	NOUN
gs-4132	72	19	share	share	AUX
gs-4132	72	20	overlapping	overlap	VERB
gs-4132	72	21	cargo	cargo	NOUN
gs-4132	72	22	and	and	CCONJ
gs-4132	72	23	functions	function	NOUN
gs-4132	72	24	but	but	CCONJ
gs-4132	72	25	differ	differ	VERB
gs-4132	72	26	in	in	ADP
gs-4132	72	27	biogenesis	biogenesis	NOUN
gs-4132	72	28	and	and	CCONJ
gs-4132	72	29	surface	surface	NOUN
gs-4132	72	30	markers	marker	NOUN
gs-4132	72	31	.	.	PUNCT
gs-4132	73	1	while	while	SCONJ
gs-4132	73	2	exosomes	exosome	NOUN
gs-4132	73	3	are	be	AUX
gs-4132	73	4	enriched	enrich	VERB
gs-4132	73	5	in	in	ADP
gs-4132	73	6	tetraspanins	tetraspanin	NOUN
gs-4132	73	7	and	and	CCONJ
gs-4132	73	8	escrt	escrt	NUM
gs-4132	73	9	-	-	PUNCT
gs-4132	73	10	associated	associate	VERB
gs-4132	73	11	proteins	protein	NOUN
gs-4132	73	12	,	,	PUNCT
gs-4132	73	13	microvesicles	microvesicle	NOUN
gs-4132	73	14	often	often	ADV
gs-4132	73	15	display	display	VERB
gs-4132	73	16	phosphatidylserine	phosphatidylserine	NOUN
gs-4132	73	17	exposure	exposure	NOUN
gs-4132	73	18	and	and	CCONJ
gs-4132	73	19	cytoskeletal	cytoskeletal	ADJ
gs-4132	73	20	proteins	protein	NOUN
gs-4132	73	21	(	(	PUNCT
gs-4132	73	22	colombo	colombo	NOUN
gs-4132	73	23	et	et	NOUN
gs-4132	73	24	al	al	PROPN
gs-4132	73	25	.	.	PROPN
gs-4132	73	26	,	,	PUNCT
gs-4132	73	27	2014	2014	NUM
gs-4132	73	28	)	)	PUNCT
gs-4132	73	29	.	.	PUNCT
gs-4132	74	1	importantly	importantly	ADV
gs-4132	74	2	,	,	PUNCT
gs-4132	74	3	both	both	DET
gs-4132	74	4	exosomes	exosome	NOUN
gs-4132	74	5	and	and	CCONJ
gs-4132	74	6	microvesicles	microvesicle	NOUN
gs-4132	74	7	can	can	AUX
gs-4132	74	8	be	be	AUX
gs-4132	74	9	engineered	engineer	VERB
gs-4132	74	10	as	as	ADP
gs-4132	74	11	drug	drug	NOUN
gs-4132	74	12	carriers	carrier	NOUN
gs-4132	74	13	.	.	PUNCT
gs-4132	75	1	some	some	DET
gs-4132	75	2	studies	study	NOUN
gs-4132	75	3	suggest	suggest	VERB
gs-4132	75	4	microvesicles	microvesicle	NOUN
gs-4132	75	5	have	have	VERB
gs-4132	75	6	greater	great	ADJ
gs-4132	75	7	cargo	cargo	NOUN
gs-4132	75	8	capacity	capacity	NOUN
gs-4132	75	9	due	due	ADP
gs-4132	75	10	to	to	ADP
gs-4132	75	11	their	their	PRON
gs-4132	75	12	larger	large	ADJ
gs-4132	75	13	size	size	NOUN
gs-4132	75	14	,	,	PUNCT
gs-4132	75	15	but	but	CCONJ
gs-4132	75	16	their	their	PRON
gs-4132	75	17	heterogeneity	heterogeneity	NOUN
gs-4132	75	18	complicates	complicate	VERB
gs-4132	75	19	isolation	isolation	NOUN
gs-4132	75	20	and	and	CCONJ
gs-4132	75	21	characterization	characterization	NOUN
gs-4132	75	22	(	(	PUNCT
gs-4132	75	23	van	van	PROPN
gs-4132	75	24	niel	niel	PROPN
gs-4132	75	25	et	et	PROPN
gs-4132	75	26	al	al	PROPN
gs-4132	75	27	.	.	PROPN
gs-4132	75	28	,	,	PUNCT
gs-4132	75	29	2018	2018	NUM
gs-4132	75	30	)	)	PUNCT
gs-4132	75	31	.	.	PUNCT
gs-4132	76	1	3.3	3.3	NUM
gs-4132	76	2	bacterial	bacterial	ADJ
gs-4132	76	3	outer	outer	ADJ
gs-4132	76	4	membrane	membrane	NOUN
gs-4132	76	5	vesicles	vesicle	NOUN
gs-4132	76	6	(	(	PUNCT
gs-4132	76	7	omvs	omvs	NOUN
gs-4132	76	8	)	)	PUNCT
gs-4132	76	9	beyond	beyond	ADP
gs-4132	76	10	eukaryotic	eukaryotic	ADJ
gs-4132	76	11	cells	cell	NOUN
gs-4132	76	12	,	,	PUNCT
gs-4132	76	13	bacteria	bacteria	NOUN
gs-4132	76	14	also	also	ADV
gs-4132	76	15	secrete	secrete	VERB
gs-4132	76	16	vesicles	vesicle	NOUN
gs-4132	76	17	known	know	VERB
gs-4132	76	18	as	as	ADP
gs-4132	76	19	outer	outer	ADJ
gs-4132	76	20	membrane	membrane	NOUN
gs-4132	76	21	vesicles	vesicle	NOUN
gs-4132	76	22	(	(	PUNCT
gs-4132	76	23	omvs	omvs	NOUN
gs-4132	76	24	)	)	PUNCT
gs-4132	76	25	.	.	PUNCT
gs-4132	77	1	these	these	PRON
gs-4132	77	2	are	be	AUX
gs-4132	77	3	nanoscale	nanoscale	ADJ
gs-4132	77	4	vesicles	vesicle	NOUN
gs-4132	77	5	derived	derive	VERB
gs-4132	77	6	from	from	ADP
gs-4132	77	7	gram	gram	NOUN
gs-4132	77	8	-	-	PUNCT
gs-4132	77	9	negative	negative	ADJ
gs-4132	77	10	bacteria	bacteria	NOUN
gs-4132	77	11	that	that	PRON
gs-4132	77	12	contain	contain	VERB
gs-4132	77	13	lipopolysaccharides	lipopolysaccharide	NOUN
gs-4132	77	14	,	,	PUNCT
gs-4132	77	15	proteins	protein	NOUN
gs-4132	77	16	,	,	PUNCT
gs-4132	77	17	and	and	CCONJ
gs-4132	77	18	nucleic	nucleic	ADJ
gs-4132	77	19	acids	acid	NOUN
gs-4132	77	20	(	(	PUNCT
gs-4132	77	21	schwechheimer	schwechheimer	ADJ
gs-4132	77	22	and	and	CCONJ
gs-4132	77	23	kuehn	kuehn	NOUN
gs-4132	77	24	,	,	PUNCT
gs-4132	77	25	2015	2015	NUM
gs-4132	77	26	)	)	PUNCT
gs-4132	77	27	.	.	PUNCT
gs-4132	78	1	omvs	omvs	NOUN
gs-4132	78	2	are	be	AUX
gs-4132	78	3	increasingly	increasingly	ADV
gs-4132	78	4	recognized	recognize	VERB
gs-4132	78	5	as	as	ADP
gs-4132	78	6	contributors	contributor	NOUN
gs-4132	78	7	to	to	ADP
gs-4132	78	8	host	host	NOUN
gs-4132	78	9	–	–	PUNCT
gs-4132	78	10	pathogen	pathogen	NOUN
gs-4132	78	11	interactions	interaction	NOUN
gs-4132	78	12	and	and	CCONJ
gs-4132	78	13	have	have	AUX
gs-4132	78	14	been	be	AUX
gs-4132	78	15	developed	develop	VERB
gs-4132	78	16	as	as	ADP
gs-4132	78	17	vaccine	vaccine	NOUN
gs-4132	78	18	platforms	platform	NOUN
gs-4132	78	19	,	,	PUNCT
gs-4132	78	20	e.g.	e.g.	ADV
gs-4132	78	21	,	,	PUNCT
gs-4132	78	22	meningococcal	meningococcal	ADJ
gs-4132	78	23	omv	omv	NOUN
gs-4132	78	24	-	-	PUNCT
gs-4132	78	25	based	base	VERB
gs-4132	78	26	vaccines	vaccine	NOUN
gs-4132	78	27	(	(	PUNCT
gs-4132	78	28	holst	holst	NOUN
gs-4132	78	29	et	et	PROPN
gs-4132	78	30	al	al	PROPN
gs-4132	78	31	.	.	PROPN
gs-4132	78	32	,	,	PUNCT
gs-4132	78	33	2009	2009	NUM
gs-4132	78	34	)	)	PUNCT
gs-4132	78	35	.	.	PUNCT
gs-4132	79	1	3.4	3.4	NUM
gs-4132	79	2	natural	natural	ADJ
gs-4132	79	3	nanoparticles	nanoparticle	NOUN
gs-4132	79	4	in	in	ADP
gs-4132	79	5	physiology	physiology	NOUN
gs-4132	79	6	exosomes	exosome	NOUN
gs-4132	79	7	,	,	PUNCT
gs-4132	79	8	microvesicles	microvesicle	NOUN
gs-4132	79	9	,	,	PUNCT
gs-4132	79	10	and	and	CCONJ
gs-4132	79	11	omvs	omvs	NOUN
gs-4132	79	12	are	be	AUX
gs-4132	79	13	examples	example	NOUN
gs-4132	79	14	of	of	ADP
gs-4132	79	15	evolutionarily	evolutionarily	ADV
gs-4132	79	16	conserved	conserve	VERB
gs-4132	79	17	communication	communication	NOUN
gs-4132	79	18	systems	system	NOUN
gs-4132	79	19	.	.	PUNCT
gs-4132	80	1	they	they	PRON
gs-4132	80	2	collectively	collectively	ADV
gs-4132	80	3	mediate	mediate	VERB
gs-4132	80	4	:	:	PUNCT
gs-4132	80	5	genetic	genetic	ADJ
gs-4132	80	6	exchange	exchange	NOUN
gs-4132	80	7	immune	immune	ADJ
gs-4132	80	8	regulation	regulation	NOUN
gs-4132	80	9	pathogen	pathogen	NOUN
gs-4132	80	10	-	-	PUNCT
gs-4132	80	11	host	host	NOUN
gs-4132	80	12	interactions	interaction	NOUN
gs-4132	80	13	tissue	tissue	NOUN
gs-4132	80	14	homeostasis	homeostasis	NOUN
gs-4132	80	15	harnessing	harness	VERB
gs-4132	80	16	these	these	DET
gs-4132	80	17	natural	natural	ADJ
gs-4132	80	18	nanoparticles	nanoparticle	NOUN
gs-4132	80	19	in	in	ADP
gs-4132	80	20	therapy	therapy	NOUN
gs-4132	80	21	offers	offer	VERB
gs-4132	80	22	opportunities	opportunity	NOUN
gs-4132	80	23	for	for	ADP
gs-4132	80	24	biomimicry	biomimicry	NOUN
gs-4132	80	25	,	,	PUNCT
gs-4132	80	26	but	but	CCONJ
gs-4132	80	27	it	it	PRON
gs-4132	80	28	also	also	ADV
gs-4132	80	29	raises	raise	VERB
gs-4132	80	30	challenges	challenge	NOUN
gs-4132	80	31	in	in	ADP
gs-4132	80	32	biosafety	biosafety	NOUN
gs-4132	80	33	and	and	CCONJ
gs-4132	80	34	reproducibility	reproducibility	NOUN
gs-4132	80	35	.	.	PUNCT
gs-4132	81	1	4	4	X
gs-4132	81	2	.	.	X
gs-4132	81	3	synthetic	synthetic	ADJ
gs-4132	81	4	nanoparticles	nanoparticle	NOUN
gs-4132	81	5	4.1	4.1	NUM
gs-4132	81	6	liposomes	liposome	NOUN
gs-4132	81	7	:	:	PUNCT
gs-4132	81	8	the	the	DET
gs-4132	81	9	classical	classical	ADJ
gs-4132	81	10	nanocarrier	nanocarrier	NOUN
gs-4132	81	11	liposomes	liposome	NOUN
gs-4132	81	12	,	,	PUNCT
gs-4132	81	13	discovered	discover	VERB
gs-4132	81	14	in	in	ADP
gs-4132	81	15	the	the	DET
gs-4132	81	16	1960s	1960	NOUN
gs-4132	81	17	(	(	PUNCT
gs-4132	81	18	bangham	bangham	PROPN
gs-4132	81	19	et	et	PROPN
gs-4132	81	20	al	al	PROPN
gs-4132	81	21	.	.	PROPN
gs-4132	81	22	,	,	PUNCT
gs-4132	81	23	1965	1965	NUM
gs-4132	81	24	)	)	PUNCT
gs-4132	81	25	,	,	PUNCT
gs-4132	81	26	remain	remain	VERB
gs-4132	81	27	the	the	DET
gs-4132	81	28	most	most	ADV
gs-4132	81	29	clinically	clinically	ADV
gs-4132	81	30	validated	validate	VERB
gs-4132	81	31	nanoparticle	nanoparticle	NOUN
gs-4132	81	32	platform	platform	NOUN
gs-4132	81	33	.	.	PUNCT
gs-4132	82	1	structurally	structurally	ADV
gs-4132	82	2	,	,	PUNCT
gs-4132	82	3	liposomes	liposome	NOUN
gs-4132	82	4	are	be	AUX
gs-4132	82	5	spherical	spherical	ADJ
gs-4132	82	6	vesicles	vesicle	NOUN
gs-4132	82	7	with	with	ADP
gs-4132	82	8	one	one	NUM
gs-4132	82	9	or	or	CCONJ
gs-4132	82	10	more	more	ADJ
gs-4132	82	11	phospholipid	phospholipid	NOUN
gs-4132	82	12	bilayers	bilayer	NOUN
gs-4132	82	13	enclosing	enclose	VERB
gs-4132	82	14	an	an	DET
gs-4132	82	15	aqueous	aqueous	ADJ
gs-4132	82	16	core	core	NOUN
gs-4132	82	17	.	.	PUNCT
gs-4132	83	1	they	they	PRON
gs-4132	83	2	can	can	AUX
gs-4132	83	3	encapsulate	encapsulate	VERB
gs-4132	83	4	hydrophilic	hydrophilic	ADJ
gs-4132	83	5	molecules	molecule	NOUN
gs-4132	83	6	in	in	ADP
gs-4132	83	7	the	the	DET
gs-4132	83	8	core	core	NOUN
gs-4132	83	9	and	and	CCONJ
gs-4132	83	10	hydrophobic	hydrophobic	NOUN
gs-4132	83	11	molecules	molecule	NOUN
gs-4132	83	12	in	in	ADP
gs-4132	83	13	the	the	DET
gs-4132	83	14	lipid	lipid	NOUN
gs-4132	83	15	bilayer	bilayer	NOUN
gs-4132	83	16	.	.	PUNCT
gs-4132	84	1	georgian	georgian	NOUN
gs-4132	84	2	scientists/	scientists/	NUM
gs-4132	84	3	.	.	PUNCT
gs-4132	85	1	7	7	NUM
gs-4132	85	2	n	n	DET
gs-4132	85	3	4	4	NUM
gs-4132	85	4	,	,	PUNCT
gs-4132	85	5	2025	2025	NUM
gs-4132	85	6	7	7	NUM
gs-4132	85	7	4.1.1	4.1.1	NUM
gs-4132	85	8	liposome	liposome	NOUN
gs-4132	85	9	engineering	engineering	NOUN
gs-4132	85	10	strategies	strategy	NOUN
gs-4132	85	11	pegylation	pegylation	NOUN
gs-4132	85	12	improves	improve	VERB
gs-4132	85	13	circulation	circulation	NOUN
gs-4132	85	14	half	half	ADJ
gs-4132	85	15	-	-	PUNCT
gs-4132	85	16	life	life	NOUN
gs-4132	85	17	by	by	ADP
gs-4132	85	18	shielding	shield	VERB
gs-4132	85	19	against	against	ADP
gs-4132	85	20	opsonization	opsonization	NOUN
gs-4132	85	21	(	(	PUNCT
gs-4132	85	22	allen	allen	NOUN
gs-4132	85	23	and	and	CCONJ
gs-4132	85	24	cullis	cullis	PROPN
gs-4132	85	25	,	,	PUNCT
gs-4132	85	26	2013	2013	NUM
gs-4132	85	27	)	)	PUNCT
gs-4132	85	28	.	.	PUNCT
gs-4132	86	1	ligand	ligand	PROPN
gs-4132	86	2	conjugation	conjugation	NOUN
gs-4132	86	3	enables	enable	VERB
gs-4132	86	4	receptor	receptor	NOUN
gs-4132	86	5	-	-	PUNCT
gs-4132	86	6	specific	specific	ADJ
gs-4132	86	7	targeting	targeting	NOUN
gs-4132	86	8	(	(	PUNCT
gs-4132	86	9	torchilin	torchilin	NOUN
gs-4132	86	10	,	,	PUNCT
gs-4132	86	11	2014	2014	NUM
gs-4132	86	12	)	)	PUNCT
gs-4132	86	13	.	.	PUNCT
gs-4132	87	1	triggered	trigger	VERB
gs-4132	87	2	release	release	NOUN
gs-4132	87	3	systems	system	NOUN
gs-4132	87	4	use	use	VERB
gs-4132	87	5	ph	ph	ADJ
gs-4132	87	6	-	-	ADJ
gs-4132	87	7	sensitive	sensitive	ADJ
gs-4132	87	8	or	or	CCONJ
gs-4132	87	9	thermo	thermo	NOUN
gs-4132	87	10	-	-	PUNCT
gs-4132	87	11	sensitive	sensitive	ADJ
gs-4132	87	12	lipids	lipid	NOUN
gs-4132	87	13	to	to	PART
gs-4132	87	14	enable	enable	VERB
gs-4132	87	15	drug	drug	NOUN
gs-4132	87	16	release	release	NOUN
gs-4132	87	17	in	in	ADP
gs-4132	87	18	response	response	NOUN
gs-4132	87	19	to	to	ADP
gs-4132	87	20	the	the	DET
gs-4132	87	21	tumor	tumor	NOUN
gs-4132	87	22	microenvironment	microenvironment	NOUN
gs-4132	87	23	(	(	PUNCT
gs-4132	87	24	zhu	zhu	PROPN
gs-4132	87	25	and	and	CCONJ
gs-4132	87	26	torchilin	torchilin	NOUN
gs-4132	87	27	,	,	PUNCT
gs-4132	87	28	2013	2013	NUM
gs-4132	87	29	)	)	PUNCT
gs-4132	87	30	.	.	PUNCT
gs-4132	88	1	4.1.2	4.1.2	NUM
gs-4132	88	2	clinically	clinically	ADV
gs-4132	88	3	approved	approve	VERB
gs-4132	88	4	liposome	liposome	NOUN
gs-4132	88	5	formulations	formulation	NOUN
gs-4132	88	6	doxil	doxil	NOUN
gs-4132	88	7	®	®	PROPN
gs-4132	88	8	/	/	SYM
gs-4132	88	9	caelyx	caelyx	NOUN
gs-4132	88	10	®	®	NOUN
gs-4132	88	11	–	–	PUNCT
gs-4132	88	12	liposomal	liposomal	ADJ
gs-4132	88	13	doxorubicin	doxorubicin	PROPN
gs-4132	88	14	for	for	ADP
gs-4132	88	15	cancer	cancer	NOUN
gs-4132	88	16	treatment	treatment	NOUN
gs-4132	88	17	(	(	PUNCT
gs-4132	88	18	barenholz	barenholz	NOUN
gs-4132	88	19	,	,	PUNCT
gs-4132	88	20	2012	2012	NUM
gs-4132	88	21	)	)	PUNCT
gs-4132	88	22	.	.	PUNCT
gs-4132	89	1	ambisome	ambisome	PROPN
gs-4132	89	2	®	®	NOUN
gs-4132	89	3	–	–	PUNCT
gs-4132	89	4	liposomal	liposomal	ADJ
gs-4132	89	5	amphotericin	amphotericin	ADP
gs-4132	89	6	b	b	NOUN
gs-4132	89	7	for	for	ADP
gs-4132	89	8	fungal	fungal	ADJ
gs-4132	89	9	infections	infection	NOUN
gs-4132	89	10	(	(	PUNCT
gs-4132	89	11	adler	adler	NOUN
gs-4132	89	12	-	-	PUNCT
gs-4132	89	13	moore	moore	PROPN
gs-4132	89	14	and	and	CCONJ
gs-4132	89	15	proffitt	proffitt	NOUN
gs-4132	89	16	,	,	PUNCT
gs-4132	89	17	2002	2002	NUM
gs-4132	89	18	)	)	PUNCT
gs-4132	89	19	.	.	PUNCT
gs-4132	90	1	onivyde	onivyde	PROPN
gs-4132	90	2	®	®	NOUN
gs-4132	90	3	–	–	PUNCT
gs-4132	90	4	liposomal	liposomal	ADJ
gs-4132	90	5	irinotecan	irinotecan	NOUN
gs-4132	90	6	for	for	ADP
gs-4132	90	7	pancreatic	pancreatic	ADJ
gs-4132	90	8	cancer	cancer	NOUN
gs-4132	90	9	(	(	PUNCT
gs-4132	90	10	wang	wang	PROPN
gs-4132	90	11	-	-	PUNCT
gs-4132	90	12	gillam	gillam	PROPN
gs-4132	90	13	et	et	PROPN
gs-4132	90	14	al	al	PROPN
gs-4132	90	15	.	.	PROPN
gs-4132	90	16	,	,	PUNCT
gs-4132	90	17	2016	2016	NUM
gs-4132	90	18	)	)	PUNCT
gs-4132	90	19	.	.	PUNCT
gs-4132	91	1	these	these	DET
gs-4132	91	2	successes	success	NOUN
gs-4132	91	3	illustrate	illustrate	VERB
gs-4132	91	4	how	how	SCONJ
gs-4132	91	5	synthetic	synthetic	ADJ
gs-4132	91	6	vesicles	vesicle	NOUN
gs-4132	91	7	pioneered	pioneer	VERB
gs-4132	91	8	nanomedicine	nanomedicine	ADJ
gs-4132	91	9	translation	translation	NOUN
gs-4132	91	10	,	,	PUNCT
gs-4132	91	11	long	long	ADV
gs-4132	91	12	before	before	SCONJ
gs-4132	91	13	exosomes	exosome	NOUN
gs-4132	91	14	entered	enter	VERB
gs-4132	91	15	the	the	DET
gs-4132	91	16	scene	scene	NOUN
gs-4132	91	17	.	.	PUNCT
gs-4132	92	1	4.2	4.2	NUM
gs-4132	92	2	polymeric	polymeric	ADJ
gs-4132	92	3	nanoparticles	nanoparticle	NOUN
gs-4132	92	4	polymeric	polymeric	ADJ
gs-4132	92	5	systems	system	NOUN
gs-4132	92	6	provide	provide	VERB
gs-4132	92	7	controlled	control	VERB
gs-4132	92	8	degradation	degradation	NOUN
gs-4132	92	9	and	and	CCONJ
gs-4132	92	10	release	release	NOUN
gs-4132	92	11	.	.	PUNCT
gs-4132	93	1	the	the	DET
gs-4132	93	2	most	most	ADV
gs-4132	93	3	widely	widely	ADV
gs-4132	93	4	used	use	VERB
gs-4132	93	5	is	be	AUX
gs-4132	93	6	poly(lactic	poly(lactic	PROPN
gs-4132	93	7	-	-	PUNCT
gs-4132	93	8	co	co	NOUN
gs-4132	93	9	-	-	ADJ
gs-4132	93	10	glycolic	glycolic	ADJ
gs-4132	93	11	acid	acid	NOUN
gs-4132	93	12	)	)	PUNCT
gs-4132	93	13	(	(	PUNCT
gs-4132	93	14	plga	plga	NOUN
gs-4132	93	15	)	)	PUNCT
gs-4132	93	16	,	,	PUNCT
gs-4132	93	17	approved	approve	VERB
gs-4132	93	18	by	by	ADP
gs-4132	93	19	the	the	DET
gs-4132	93	20	fda	fda	PROPN
gs-4132	93	21	for	for	ADP
gs-4132	93	22	various	various	ADJ
gs-4132	93	23	biomedical	biomedical	ADJ
gs-4132	93	24	applications	application	NOUN
gs-4132	93	25	(	(	PUNCT
gs-4132	93	26	danhier	danhier	NOUN
gs-4132	93	27	et	et	PROPN
gs-4132	93	28	al	al	PROPN
gs-4132	93	29	.	.	PROPN
gs-4132	93	30	,	,	PUNCT
gs-4132	93	31	2012	2012	NUM
gs-4132	93	32	)	)	PUNCT
gs-4132	93	33	.	.	PUNCT
gs-4132	94	1	advantages	advantage	NOUN
gs-4132	94	2	:	:	PUNCT
gs-4132	94	3	tunable	tunable	ADJ
gs-4132	94	4	degradation	degradation	NOUN
gs-4132	94	5	rate	rate	NOUN
gs-4132	94	6	.	.	PUNCT
gs-4132	95	1	high	high	ADJ
gs-4132	95	2	drug	drug	NOUN
gs-4132	95	3	encapsulation	encapsulation	NOUN
gs-4132	95	4	.	.	PUNCT
gs-4132	96	1	surface	surface	NOUN
gs-4132	96	2	functionalization	functionalization	NOUN
gs-4132	96	3	possibilities	possibility	NOUN
gs-4132	96	4	.	.	PUNCT
gs-4132	97	1	applications	application	NOUN
gs-4132	97	2	include	include	VERB
gs-4132	97	3	delivery	delivery	NOUN
gs-4132	97	4	of	of	ADP
gs-4132	97	5	chemotherapeutics	chemotherapeutic	NOUN
gs-4132	97	6	,	,	PUNCT
gs-4132	97	7	vaccines	vaccine	NOUN
gs-4132	97	8	,	,	PUNCT
gs-4132	97	9	and	and	CCONJ
gs-4132	97	10	genetic	genetic	ADJ
gs-4132	97	11	material	material	NOUN
gs-4132	97	12	(	(	PUNCT
gs-4132	97	13	makadia	makadia	NOUN
gs-4132	97	14	and	and	CCONJ
gs-4132	97	15	siegel	siegel	NOUN
gs-4132	97	16	,	,	PUNCT
gs-4132	97	17	2011	2011	NUM
gs-4132	97	18	)	)	PUNCT
gs-4132	97	19	.	.	PUNCT
gs-4132	98	1	4.3	4.3	NUM
gs-4132	98	2	dendrimers	dendrimer	NOUN
gs-4132	98	3	dendrimers	dendrimer	NOUN
gs-4132	98	4	are	be	AUX
gs-4132	98	5	highly	highly	ADV
gs-4132	98	6	branched	branched	ADJ
gs-4132	98	7	synthetic	synthetic	ADJ
gs-4132	98	8	macromolecules	macromolecule	NOUN
gs-4132	98	9	with	with	ADP
gs-4132	98	10	well	well	ADV
gs-4132	98	11	-	-	PUNCT
gs-4132	98	12	defined	define	VERB
gs-4132	98	13	structures	structure	NOUN
gs-4132	98	14	.	.	PUNCT
gs-4132	99	1	they	they	PRON
gs-4132	99	2	provide	provide	VERB
gs-4132	99	3	multivalent	multivalent	NOUN
gs-4132	99	4	surface	surface	NOUN
gs-4132	99	5	groups	group	NOUN
gs-4132	99	6	for	for	ADP
gs-4132	99	7	drug	drug	NOUN
gs-4132	99	8	,	,	PUNCT
gs-4132	99	9	peptide	peptide	NOUN
gs-4132	99	10	,	,	PUNCT
gs-4132	99	11	or	or	CCONJ
gs-4132	99	12	gene	gene	NOUN
gs-4132	99	13	conjugation	conjugation	NOUN
gs-4132	99	14	(	(	PUNCT
gs-4132	99	15	gillies	gillie	NOUN
gs-4132	99	16	and	and	CCONJ
gs-4132	99	17	fréchet	fréchet	NOUN
gs-4132	99	18	,	,	PUNCT
gs-4132	99	19	2005	2005	NUM
gs-4132	99	20	)	)	PUNCT
gs-4132	99	21	.	.	PUNCT
gs-4132	100	1	advantages	advantage	NOUN
gs-4132	100	2	:	:	PUNCT
gs-4132	100	3	precise	precise	ADJ
gs-4132	100	4	size	size	NOUN
gs-4132	100	5	,	,	PUNCT
gs-4132	100	6	controlled	control	VERB
gs-4132	100	7	architecture	architecture	NOUN
gs-4132	100	8	,	,	PUNCT
gs-4132	100	9	multivalency	multivalency	NOUN
gs-4132	100	10	.	.	PUNCT
gs-4132	101	1	limitations	limitation	NOUN
gs-4132	101	2	:	:	PUNCT
gs-4132	101	3	potential	potential	ADJ
gs-4132	101	4	toxicity	toxicity	NOUN
gs-4132	101	5	,	,	PUNCT
gs-4132	101	6	complex	complex	ADJ
gs-4132	101	7	synthesis	synthesis	NOUN
gs-4132	101	8	.	.	PUNCT
gs-4132	102	1	4.4	4.4	NUM
gs-4132	102	2	inorganic	inorganic	ADJ
gs-4132	102	3	nanoparticles	nanoparticle	NOUN
gs-4132	102	4	inorganic	inorganic	ADJ
gs-4132	102	5	nanomaterials	nanomaterial	NOUN
gs-4132	102	6	,	,	PUNCT
gs-4132	102	7	such	such	ADJ
gs-4132	102	8	as	as	ADP
gs-4132	102	9	gold	gold	ADJ
gs-4132	102	10	nanoparticles	nanoparticle	NOUN
gs-4132	102	11	,	,	PUNCT
gs-4132	102	12	silica	silica	NOUN
gs-4132	102	13	nanoparticles	nanoparticle	NOUN
gs-4132	102	14	,	,	PUNCT
gs-4132	102	15	and	and	CCONJ
gs-4132	102	16	iron	iron	NOUN
gs-4132	102	17	oxide	oxide	NOUN
gs-4132	102	18	nanoparticles	nanoparticle	NOUN
gs-4132	102	19	,	,	PUNCT
gs-4132	102	20	are	be	AUX
gs-4132	102	21	widely	widely	ADV
gs-4132	102	22	studied	study	VERB
gs-4132	102	23	for	for	ADP
gs-4132	102	24	diagnostics	diagnostic	NOUN
gs-4132	102	25	and	and	CCONJ
gs-4132	102	26	therapy	therapy	NOUN
gs-4132	102	27	.	.	PUNCT
gs-4132	103	1	gold	gold	ADJ
gs-4132	103	2	nanoparticles	nanoparticle	NOUN
gs-4132	103	3	are	be	AUX
gs-4132	103	4	used	use	VERB
gs-4132	103	5	for	for	ADP
gs-4132	103	6	photothermal	photothermal	ADJ
gs-4132	103	7	therapy	therapy	NOUN
gs-4132	103	8	(	(	PUNCT
gs-4132	103	9	jain	jain	PROPN
gs-4132	103	10	et	et	PROPN
gs-4132	103	11	al	al	PROPN
gs-4132	103	12	.	.	PROPN
gs-4132	103	13	,	,	PUNCT
gs-4132	103	14	2012	2012	NUM
gs-4132	103	15	)	)	PUNCT
gs-4132	103	16	.	.	PUNCT
gs-4132	104	1	georgian	georgian	NOUN
gs-4132	104	2	scientists/	scientists/	NUM
gs-4132	104	3	.	.	PUNCT
gs-4132	105	1	7	7	NUM
gs-4132	105	2	n	n	DET
gs-4132	105	3	4	4	NUM
gs-4132	105	4	,	,	PUNCT
gs-4132	105	5	2025	2025	NUM
gs-4132	105	6	8	8	NUM
gs-4132	105	7	iron	iron	NOUN
gs-4132	105	8	oxide	oxide	NOUN
gs-4132	105	9	nanoparticles	nanoparticle	NOUN
gs-4132	105	10	serve	serve	VERB
gs-4132	105	11	as	as	ADP
gs-4132	105	12	mri	mri	NOUN
gs-4132	105	13	contrast	contrast	NOUN
gs-4132	105	14	agents	agent	NOUN
gs-4132	105	15	(	(	PUNCT
gs-4132	105	16	gupta	gupta	NOUN
gs-4132	105	17	and	and	CCONJ
gs-4132	105	18	gupta	gupta	PROPN
gs-4132	105	19	,	,	PUNCT
gs-4132	105	20	2005	2005	NUM
gs-4132	105	21	)	)	PUNCT
gs-4132	105	22	.	.	PUNCT
gs-4132	106	1	mesoporous	mesoporous	ADJ
gs-4132	106	2	silica	silica	NOUN
gs-4132	106	3	nanoparticles	nanoparticle	NOUN
gs-4132	106	4	are	be	AUX
gs-4132	106	5	explored	explore	VERB
gs-4132	106	6	for	for	ADP
gs-4132	106	7	drug	drug	NOUN
gs-4132	106	8	delivery	delivery	NOUN
gs-4132	106	9	due	due	ADP
gs-4132	106	10	to	to	ADP
gs-4132	106	11	high	high	ADJ
gs-4132	106	12	surface	surface	NOUN
gs-4132	106	13	area	area	NOUN
gs-4132	106	14	(	(	PUNCT
gs-4132	106	15	mamaeva	mamaeva	PROPN
gs-4132	106	16	et	et	PROPN
gs-4132	106	17	al	al	PROPN
gs-4132	106	18	.	.	PROPN
gs-4132	106	19	,	,	PUNCT
gs-4132	106	20	2013	2013	NUM
gs-4132	106	21	)	)	PUNCT
gs-4132	106	22	.	.	PUNCT
gs-4132	107	1	4.5	4.5	NUM
gs-4132	107	2	extracellular	extracellular	ADJ
gs-4132	107	3	vesicle	vesicle	NOUN
gs-4132	107	4	-	-	PUNCT
gs-4132	107	5	mimetics	mimetic	NOUN
gs-4132	107	6	and	and	CCONJ
gs-4132	107	7	hybrid	hybrid	ADJ
gs-4132	107	8	systems	system	NOUN
gs-4132	107	9	to	to	PART
gs-4132	107	10	overcome	overcome	VERB
gs-4132	107	11	scalability	scalability	NOUN
gs-4132	107	12	challenges	challenge	NOUN
gs-4132	107	13	of	of	ADP
gs-4132	107	14	exosomes	exosome	NOUN
gs-4132	107	15	,	,	PUNCT
gs-4132	107	16	researchers	researcher	NOUN
gs-4132	107	17	have	have	AUX
gs-4132	107	18	developed	develop	VERB
gs-4132	107	19	exosome	exosome	NOUN
gs-4132	107	20	-	-	PUNCT
gs-4132	107	21	mimetics	mimetic	NOUN
gs-4132	107	22	.	.	PUNCT
gs-4132	108	1	these	these	PRON
gs-4132	108	2	are	be	AUX
gs-4132	108	3	generated	generate	VERB
gs-4132	108	4	by	by	ADP
gs-4132	108	5	:	:	PUNCT
gs-4132	108	6	extrusion	extrusion	NOUN
gs-4132	108	7	of	of	ADP
gs-4132	108	8	cells	cell	NOUN
gs-4132	108	9	through	through	ADP
gs-4132	108	10	filters	filter	NOUN
gs-4132	108	11	to	to	PART
gs-4132	108	12	produce	produce	VERB
gs-4132	108	13	vesicle	vesicle	NOUN
gs-4132	108	14	-	-	PUNCT
gs-4132	108	15	like	like	ADJ
gs-4132	108	16	particles	particle	NOUN
gs-4132	108	17	.	.	PUNCT
gs-4132	109	1	synthetic	synthetic	ADJ
gs-4132	109	2	lipid	lipid	NOUN
gs-4132	109	3	assembly	assembly	NOUN
gs-4132	109	4	incorporating	incorporate	VERB
gs-4132	109	5	key	key	ADJ
gs-4132	109	6	exosomal	exosomal	ADJ
gs-4132	109	7	proteins	protein	NOUN
gs-4132	109	8	.	.	PUNCT
gs-4132	110	1	ev	ev	VERB
gs-4132	110	2	-	-	PUNCT
gs-4132	110	3	mimetic	mimetic	ADJ
gs-4132	110	4	systems	system	NOUN
gs-4132	110	5	aim	aim	VERB
gs-4132	110	6	to	to	PART
gs-4132	110	7	combine	combine	VERB
gs-4132	110	8	the	the	DET
gs-4132	110	9	natural	natural	ADJ
gs-4132	110	10	targeting	targeting	NOUN
gs-4132	110	11	of	of	ADP
gs-4132	110	12	exosomes	exosome	NOUN
gs-4132	110	13	with	with	ADP
gs-4132	110	14	the	the	DET
gs-4132	110	15	scalability	scalability	NOUN
gs-4132	110	16	of	of	ADP
gs-4132	110	17	liposomes	liposome	NOUN
gs-4132	110	18	(	(	PUNCT
gs-4132	110	19	jang	jang	PROPN
gs-4132	110	20	et	et	PROPN
gs-4132	110	21	al	al	PROPN
gs-4132	110	22	.	.	PROPN
gs-4132	110	23	,	,	PUNCT
gs-4132	110	24	2013	2013	NUM
gs-4132	110	25	)	)	PUNCT
gs-4132	110	26	.	.	PUNCT
gs-4132	111	1	hybrid	hybrid	ADJ
gs-4132	111	2	approaches	approach	NOUN
gs-4132	111	3	,	,	PUNCT
gs-4132	111	4	where	where	SCONJ
gs-4132	111	5	exosomes	exosome	NOUN
gs-4132	111	6	are	be	AUX
gs-4132	111	7	fused	fuse	VERB
gs-4132	111	8	with	with	ADP
gs-4132	111	9	liposomes	liposome	NOUN
gs-4132	111	10	,	,	PUNCT
gs-4132	111	11	are	be	AUX
gs-4132	111	12	also	also	ADV
gs-4132	111	13	under	under	ADP
gs-4132	111	14	development	development	NOUN
gs-4132	111	15	to	to	ADP
gs-4132	111	16	harness	harness	NOUN
gs-4132	111	17	the	the	DET
gs-4132	111	18	best	good	ADJ
gs-4132	111	19	of	of	ADP
gs-4132	111	20	both	both	DET
gs-4132	111	21	worlds	world	NOUN
gs-4132	111	22	.	.	PUNCT
gs-4132	112	1	5	5	X
gs-4132	112	2	.	.	X
gs-4132	112	3	comparative	comparative	ADJ
gs-4132	112	4	insights	insight	NOUN
gs-4132	112	5	:	:	PUNCT
gs-4132	112	6	natural	natural	ADJ
gs-4132	112	7	vs	vs	ADP
gs-4132	112	8	synthetic	synthetic	ADJ
gs-4132	112	9	particles	particle	NOUN
gs-4132	112	10	5.1	5.1	NUM
gs-4132	112	11	biocompatibility	biocompatibility	NOUN
gs-4132	112	12	exosomes	exosome	NOUN
gs-4132	112	13	are	be	AUX
gs-4132	112	14	inherently	inherently	ADV
gs-4132	112	15	biocompatible	biocompatible	ADJ
gs-4132	112	16	and	and	CCONJ
gs-4132	112	17	less	less	ADV
gs-4132	112	18	immunogenic	immunogenic	ADJ
gs-4132	112	19	since	since	SCONJ
gs-4132	112	20	they	they	PRON
gs-4132	112	21	originate	originate	VERB
gs-4132	112	22	from	from	ADP
gs-4132	112	23	host	host	NOUN
gs-4132	112	24	cells	cell	NOUN
gs-4132	112	25	(	(	PUNCT
gs-4132	112	26	lener	lener	NOUN
gs-4132	112	27	et	et	PROPN
gs-4132	112	28	al	al	PROPN
gs-4132	112	29	.	.	PROPN
gs-4132	112	30	,	,	PUNCT
gs-4132	112	31	2015	2015	NUM
gs-4132	112	32	)	)	PUNCT
gs-4132	112	33	.	.	PUNCT
gs-4132	113	1	liposomes	liposome	NOUN
gs-4132	113	2	,	,	PUNCT
gs-4132	113	3	though	though	SCONJ
gs-4132	113	4	well	well	ADV
gs-4132	113	5	tolerated	tolerate	VERB
gs-4132	113	6	,	,	PUNCT
gs-4132	113	7	can	can	AUX
gs-4132	113	8	trigger	trigger	VERB
gs-4132	113	9	complement	complement	NOUN
gs-4132	113	10	activation	activation	NOUN
gs-4132	113	11	(	(	PUNCT
gs-4132	113	12	szebeni	szebeni	NOUN
gs-4132	113	13	,	,	PUNCT
gs-4132	113	14	2005	2005	NUM
gs-4132	113	15	)	)	PUNCT
gs-4132	113	16	.	.	PUNCT
gs-4132	114	1	5.2	5.2	NUM
gs-4132	114	2	targeting	target	VERB
gs-4132	114	3	ability	ability	NOUN
gs-4132	114	4	exosomes	exosome	NOUN
gs-4132	114	5	display	display	VERB
gs-4132	114	6	natural	natural	ADJ
gs-4132	114	7	tropism	tropism	NOUN
gs-4132	114	8	guided	guide	VERB
gs-4132	114	9	by	by	ADP
gs-4132	114	10	surface	surface	NOUN
gs-4132	114	11	integrins	integrin	NOUN
gs-4132	114	12	and	and	CCONJ
gs-4132	114	13	tetraspanins	tetraspanin	NOUN
gs-4132	114	14	(	(	PUNCT
gs-4132	114	15	hoshino	hoshino	PROPN
gs-4132	114	16	et	et	PROPN
gs-4132	114	17	al	al	PROPN
gs-4132	114	18	.	.	PROPN
gs-4132	114	19	,	,	PUNCT
gs-4132	114	20	2015	2015	NUM
gs-4132	114	21	)	)	PUNCT
gs-4132	114	22	.	.	PUNCT
gs-4132	115	1	liposomes	liposome	NOUN
gs-4132	115	2	require	require	VERB
gs-4132	115	3	engineered	engineer	VERB
gs-4132	115	4	ligands	ligand	NOUN
gs-4132	115	5	or	or	CCONJ
gs-4132	115	6	antibodies	antibody	NOUN
gs-4132	115	7	for	for	ADP
gs-4132	115	8	specific	specific	ADJ
gs-4132	115	9	targeting	targeting	NOUN
gs-4132	115	10	.	.	PUNCT
gs-4132	116	1	5.3	5.3	NUM
gs-4132	116	2	drug	drug	NOUN
gs-4132	116	3	loading	loading	NOUN
gs-4132	116	4	capacity	capacity	NOUN
gs-4132	116	5	liposomes	liposome	NOUN
gs-4132	116	6	allow	allow	VERB
gs-4132	116	7	predictable	predictable	ADJ
gs-4132	116	8	,	,	PUNCT
gs-4132	116	9	high	high	ADJ
gs-4132	116	10	-	-	PUNCT
gs-4132	116	11	efficiency	efficiency	NOUN
gs-4132	116	12	loading	loading	NOUN
gs-4132	116	13	of	of	ADP
gs-4132	116	14	small	small	ADJ
gs-4132	116	15	molecules	molecule	NOUN
gs-4132	116	16	.	.	PUNCT
gs-4132	117	1	exosome	exosome	PROPN
gs-4132	117	2	loading	loading	NOUN
gs-4132	117	3	is	be	AUX
gs-4132	117	4	more	more	ADV
gs-4132	117	5	complex	complex	ADJ
gs-4132	117	6	,	,	PUNCT
gs-4132	117	7	often	often	ADV
gs-4132	117	8	requiring	require	VERB
gs-4132	117	9	electroporation	electroporation	NOUN
gs-4132	117	10	,	,	PUNCT
gs-4132	117	11	transfection	transfection	NOUN
gs-4132	117	12	,	,	PUNCT
gs-4132	117	13	or	or	CCONJ
gs-4132	117	14	chemical	chemical	NOUN
gs-4132	117	15	modification	modification	NOUN
gs-4132	117	16	(	(	PUNCT
gs-4132	117	17	vader	vader	NOUN
gs-4132	117	18	et	et	PROPN
gs-4132	117	19	al	al	PROPN
gs-4132	117	20	.	.	PROPN
gs-4132	117	21	,	,	PUNCT
gs-4132	117	22	2016	2016	NUM
gs-4132	117	23	)	)	PUNCT
gs-4132	117	24	.	.	PUNCT
gs-4132	118	1	5.4	5.4	NUM
gs-4132	118	2	manufacturing	manufacturing	NOUN
gs-4132	118	3	and	and	CCONJ
gs-4132	118	4	scalability	scalability	NOUN
gs-4132	118	5	liposome	liposome	NOUN
gs-4132	118	6	production	production	NOUN
gs-4132	118	7	is	be	AUX
gs-4132	118	8	standardized	standardized	ADJ
gs-4132	118	9	and	and	CCONJ
gs-4132	118	10	scalable	scalable	ADJ
gs-4132	118	11	,	,	PUNCT
gs-4132	118	12	enabling	enable	VERB
gs-4132	118	13	mass	mass	NOUN
gs-4132	118	14	manufacturing	manufacturing	NOUN
gs-4132	118	15	under	under	ADP
gs-4132	118	16	gmp	gmp	PROPN
gs-4132	118	17	.	.	PUNCT
gs-4132	119	1	exosome	exosome	PROPN
gs-4132	119	2	isolation	isolation	NOUN
gs-4132	119	3	and	and	CCONJ
gs-4132	119	4	purification	purification	NOUN
gs-4132	119	5	remain	remain	VERB
gs-4132	119	6	technically	technically	ADV
gs-4132	119	7	challenging	challenging	ADJ
gs-4132	119	8	due	due	ADJ
gs-4132	119	9	to	to	ADP
gs-4132	119	10	heterogeneity	heterogeneity	NOUN
gs-4132	119	11	(	(	PUNCT
gs-4132	119	12	lötvall	lötvall	INTJ
gs-4132	119	13	et	et	PROPN
gs-4132	119	14	al	al	PROPN
gs-4132	119	15	.	.	PROPN
gs-4132	119	16	,	,	PUNCT
gs-4132	119	17	2014	2014	NUM
gs-4132	119	18	)	)	PUNCT
gs-4132	119	19	.	.	PUNCT
gs-4132	120	1	6	6	X
gs-4132	120	2	.	.	X
gs-4132	120	3	therapeutic	therapeutic	ADJ
gs-4132	120	4	applications	application	NOUN
gs-4132	120	5	of	of	ADP
gs-4132	120	6	exosomes	exosome	NOUN
gs-4132	120	7	and	and	CCONJ
gs-4132	120	8	synthetic	synthetic	ADJ
gs-4132	120	9	nanoparticles	nanoparticle	NOUN
gs-4132	120	10	6.1	6.1	NUM
gs-4132	120	11	cancer	cancer	NOUN
gs-4132	120	12	therapy	therapy	NOUN
gs-4132	120	13	6.1.1	6.1.1	NUM
gs-4132	120	14	exosomes	exosome	NOUN
gs-4132	120	15	in	in	ADP
gs-4132	120	16	cancer	cancer	NOUN
gs-4132	120	17	progression	progression	NOUN
gs-4132	120	18	and	and	CCONJ
gs-4132	120	19	therapy	therapy	NOUN
gs-4132	120	20	cancer	cancer	NOUN
gs-4132	120	21	is	be	AUX
gs-4132	120	22	the	the	DET
gs-4132	120	23	area	area	NOUN
gs-4132	120	24	where	where	SCONJ
gs-4132	120	25	exosome	exosome	PROPN
gs-4132	120	26	research	research	NOUN
gs-4132	120	27	has	have	AUX
gs-4132	120	28	been	be	AUX
gs-4132	120	29	most	most	ADV
gs-4132	120	30	intense	intense	ADJ
gs-4132	120	31	.	.	PUNCT
gs-4132	121	1	tumor	tumor	NOUN
gs-4132	121	2	-	-	PUNCT
gs-4132	121	3	derived	derive	VERB
gs-4132	121	4	exosomes	exosome	NOUN
gs-4132	121	5	contribute	contribute	VERB
gs-4132	121	6	to	to	ADP
gs-4132	121	7	oncogenesis	oncogenesis	NOUN
gs-4132	121	8	by	by	ADP
gs-4132	121	9	promoting	promote	VERB
gs-4132	121	10	angiogenesis	angiogenesis	NOUN
gs-4132	121	11	,	,	PUNCT
gs-4132	121	12	immune	immune	ADJ
gs-4132	121	13	evasion	evasion	NOUN
gs-4132	121	14	,	,	PUNCT
gs-4132	121	15	and	and	CCONJ
gs-4132	121	16	georgian	georgian	NOUN
gs-4132	121	17	scientists/	scientists/	NUM
gs-4132	121	18	.	.	PUNCT
gs-4132	122	1	7	7	NUM
gs-4132	122	2	n	n	DET
gs-4132	122	3	4	4	NUM
gs-4132	122	4	,	,	PUNCT
gs-4132	122	5	2025	2025	NUM
gs-4132	122	6	9	9	NUM
gs-4132	122	7	metastasis	metastasis	NOUN
gs-4132	122	8	(	(	PUNCT
gs-4132	122	9	kalluri	kalluri	NOUN
gs-4132	122	10	and	and	CCONJ
gs-4132	122	11	lebleu	lebleu	PROPN
gs-4132	122	12	,	,	PUNCT
gs-4132	122	13	2020	2020	NUM
gs-4132	122	14	)	)	PUNCT
gs-4132	122	15	.	.	PUNCT
gs-4132	123	1	for	for	ADP
gs-4132	123	2	example	example	NOUN
gs-4132	123	3	,	,	PUNCT
gs-4132	123	4	melanoma	melanoma	PROPN
gs-4132	123	5	exosomes	exosome	NOUN
gs-4132	123	6	rich	rich	ADJ
gs-4132	123	7	in	in	ADP
gs-4132	123	8	integrins	integrin	NOUN
gs-4132	123	9	facilitate	facilitate	VERB
gs-4132	123	10	pre	pre	ADJ
gs-4132	123	11	-	-	ADJ
gs-4132	123	12	metastatic	metastatic	ADJ
gs-4132	123	13	niche	niche	NOUN
gs-4132	123	14	formation	formation	NOUN
gs-4132	123	15	in	in	ADP
gs-4132	123	16	distant	distant	ADJ
gs-4132	123	17	organs	organ	NOUN
gs-4132	123	18	(	(	PUNCT
gs-4132	123	19	peinado	peinado	VERB
gs-4132	123	20	et	et	PROPN
gs-4132	123	21	al	al	PROPN
gs-4132	123	22	.	.	PROPN
gs-4132	123	23	,	,	PUNCT
gs-4132	123	24	2012	2012	NUM
gs-4132	123	25	)	)	PUNCT
gs-4132	123	26	.	.	PUNCT
gs-4132	124	1	exosomes	exosome	NOUN
gs-4132	124	2	are	be	AUX
gs-4132	124	3	also	also	ADV
gs-4132	124	4	being	be	AUX
gs-4132	124	5	developed	develop	VERB
gs-4132	124	6	as	as	ADP
gs-4132	124	7	therapeutic	therapeutic	ADJ
gs-4132	124	8	tools	tool	NOUN
gs-4132	124	9	.	.	PUNCT
gs-4132	125	1	engineered	engineer	VERB
gs-4132	125	2	exosomes	exosome	NOUN
gs-4132	125	3	can	can	AUX
gs-4132	125	4	deliver	deliver	VERB
gs-4132	125	5	sirnas	sirna	NOUN
gs-4132	125	6	or	or	CCONJ
gs-4132	125	7	chemotherapeutics	chemotherapeutic	NOUN
gs-4132	125	8	directly	directly	ADV
gs-4132	125	9	to	to	ADP
gs-4132	125	10	tumor	tumor	NOUN
gs-4132	125	11	cells	cell	NOUN
gs-4132	125	12	.	.	PUNCT
gs-4132	126	1	alvarez	alvarez	PROPN
gs-4132	126	2	-	-	PUNCT
gs-4132	126	3	erviti	erviti	PROPN
gs-4132	126	4	et	et	PROPN
gs-4132	126	5	al	al	PROPN
gs-4132	126	6	.	.	PROPN
gs-4132	126	7	(	(	PUNCT
gs-4132	126	8	2011	2011	NUM
gs-4132	126	9	)	)	PUNCT
gs-4132	126	10	demonstrated	demonstrate	VERB
gs-4132	126	11	exosome	exosome	NOUN
gs-4132	126	12	-	-	PUNCT
gs-4132	126	13	mediated	mediate	VERB
gs-4132	126	14	sirna	sirna	PROPN
gs-4132	126	15	delivery	delivery	NOUN
gs-4132	126	16	to	to	ADP
gs-4132	126	17	the	the	DET
gs-4132	126	18	brain	brain	NOUN
gs-4132	126	19	,	,	PUNCT
gs-4132	126	20	a	a	DET
gs-4132	126	21	strategy	strategy	NOUN
gs-4132	126	22	now	now	ADV
gs-4132	126	23	adapted	adapt	VERB
gs-4132	126	24	for	for	ADP
gs-4132	126	25	silencing	silence	VERB
gs-4132	126	26	oncogenes	oncogene	NOUN
gs-4132	126	27	.	.	PUNCT
gs-4132	127	1	msc	msc	NOUN
gs-4132	127	2	-	-	PUNCT
gs-4132	127	3	derived	derive	VERB
gs-4132	127	4	exosomes	exosome	NOUN
gs-4132	127	5	loaded	load	VERB
gs-4132	127	6	with	with	ADP
gs-4132	127	7	paclitaxel	paclitaxel	PROPN
gs-4132	127	8	showed	show	VERB
gs-4132	127	9	potent	potent	ADJ
gs-4132	127	10	antitumor	antitumor	PROPN
gs-4132	127	11	effects	effect	NOUN
gs-4132	127	12	in	in	ADP
gs-4132	127	13	lung	lung	NOUN
gs-4132	127	14	cancer	cancer	NOUN
gs-4132	127	15	models	model	NOUN
gs-4132	127	16	(	(	PUNCT
gs-4132	127	17	kim	kim	PROPN
gs-4132	127	18	et	et	PROPN
gs-4132	127	19	al	al	PROPN
gs-4132	127	20	.	.	PROPN
gs-4132	127	21	,	,	PUNCT
gs-4132	127	22	2016	2016	NUM
gs-4132	127	23	)	)	PUNCT
gs-4132	127	24	.	.	PUNCT
gs-4132	128	1	6.1.2	6.1.2	NUM
gs-4132	128	2	liposomes	liposome	NOUN
gs-4132	128	3	in	in	ADP
gs-4132	128	4	cancer	cancer	NOUN
gs-4132	128	5	therapy	therapy	NOUN
gs-4132	128	6	liposomes	liposome	NOUN
gs-4132	128	7	have	have	AUX
gs-4132	128	8	long	long	ADV
gs-4132	128	9	been	be	AUX
gs-4132	128	10	central	central	ADJ
gs-4132	128	11	to	to	ADP
gs-4132	128	12	oncology	oncology	NOUN
gs-4132	128	13	.	.	PUNCT
gs-4132	129	1	the	the	DET
gs-4132	129	2	success	success	NOUN
gs-4132	129	3	of	of	ADP
gs-4132	129	4	doxil	doxil	NOUN
gs-4132	129	5	®	®	NOUN
gs-4132	129	6	(	(	PUNCT
gs-4132	129	7	liposomal	liposomal	PROPN
gs-4132	129	8	doxorubicin	doxorubicin	PROPN
gs-4132	129	9	)	)	PUNCT
gs-4132	129	10	demonstrated	demonstrate	VERB
gs-4132	129	11	reduced	reduced	ADJ
gs-4132	129	12	cardiotoxicity	cardiotoxicity	NOUN
gs-4132	129	13	compared	compare	VERB
gs-4132	129	14	to	to	PART
gs-4132	129	15	free	free	ADJ
gs-4132	129	16	doxorubicin	doxorubicin	PROPN
gs-4132	129	17	(	(	PUNCT
gs-4132	129	18	barenholz	barenholz	NOUN
gs-4132	129	19	,	,	PUNCT
gs-4132	129	20	2012	2012	NUM
gs-4132	129	21	)	)	PUNCT
gs-4132	129	22	.	.	PUNCT
gs-4132	130	1	similarly	similarly	ADV
gs-4132	130	2	,	,	PUNCT
gs-4132	130	3	liposomal	liposomal	ADJ
gs-4132	130	4	formulations	formulation	NOUN
gs-4132	130	5	of	of	ADP
gs-4132	130	6	cisplatin	cisplatin	NOUN
gs-4132	130	7	(	(	PUNCT
gs-4132	130	8	lipoplatin	lipoplatin	PROPN
gs-4132	130	9	®	®	PROPN
gs-4132	130	10	)	)	PUNCT
gs-4132	130	11	and	and	CCONJ
gs-4132	130	12	irinotecan	irinotecan	NOUN
gs-4132	130	13	(	(	PUNCT
gs-4132	130	14	onivyde	onivyde	PROPN
gs-4132	130	15	®	®	NOUN
gs-4132	130	16	)	)	PUNCT
gs-4132	130	17	improved	improve	VERB
gs-4132	130	18	pharmacokinetics	pharmacokinetic	NOUN
gs-4132	130	19	and	and	CCONJ
gs-4132	130	20	tumor	tumor	NOUN
gs-4132	130	21	accumulation	accumulation	NOUN
gs-4132	130	22	(	(	PUNCT
gs-4132	130	23	wanggillam	wanggillam	NOUN
gs-4132	130	24	et	et	PROPN
gs-4132	130	25	al	al	PROPN
gs-4132	130	26	.	.	PROPN
gs-4132	130	27	,	,	PUNCT
gs-4132	130	28	2016	2016	NUM
gs-4132	130	29	)	)	PUNCT
gs-4132	130	30	.	.	PUNCT
gs-4132	131	1	6.1.3	6.1.3	NUM
gs-4132	131	2	comparative	comparative	ADJ
gs-4132	131	3	perspectives	perspective	NOUN
gs-4132	131	4	exosomes	exosome	NOUN
gs-4132	131	5	:	:	PUNCT
gs-4132	131	6	better	well	ADJ
gs-4132	131	7	tissue	tissue	NOUN
gs-4132	131	8	penetration	penetration	NOUN
gs-4132	131	9	,	,	PUNCT
gs-4132	131	10	intrinsic	intrinsic	ADJ
gs-4132	131	11	targeting	targeting	NOUN
gs-4132	131	12	,	,	PUNCT
gs-4132	131	13	immunomodulatory	immunomodulatory	ADJ
gs-4132	131	14	effects	effect	NOUN
gs-4132	131	15	.	.	PUNCT
gs-4132	132	1	liposomes	liposome	NOUN
gs-4132	132	2	:	:	PUNCT
gs-4132	132	3	standardized	standardized	ADJ
gs-4132	132	4	production	production	NOUN
gs-4132	132	5	,	,	PUNCT
gs-4132	132	6	established	establish	VERB
gs-4132	132	7	regulatory	regulatory	ADJ
gs-4132	132	8	pathways	pathway	NOUN
gs-4132	132	9	.	.	PUNCT
gs-4132	133	1	future	future	ADJ
gs-4132	133	2	cancer	cancer	NOUN
gs-4132	133	3	therapy	therapy	NOUN
gs-4132	133	4	may	may	AUX
gs-4132	133	5	combine	combine	VERB
gs-4132	133	6	these	these	DET
gs-4132	133	7	systems	system	NOUN
gs-4132	133	8	:	:	PUNCT
gs-4132	133	9	exosome	exosome	NOUN
gs-4132	133	10	-	-	PUNCT
gs-4132	133	11	liposome	liposome	NOUN
gs-4132	133	12	hybrids	hybrid	NOUN
gs-4132	133	13	or	or	CCONJ
gs-4132	133	14	coadministration	coadministration	NOUN
gs-4132	133	15	strategies	strategy	NOUN
gs-4132	133	16	.	.	PUNCT
gs-4132	134	1	6.2	6.2	NUM
gs-4132	134	2	neurological	neurological	ADJ
gs-4132	134	3	disorders	disorder	NOUN
gs-4132	134	4	6.2.1	6.2.1	NUM
gs-4132	134	5	blood	blood	NOUN
gs-4132	134	6	–	–	PUNCT
gs-4132	134	7	brain	brain	NOUN
gs-4132	134	8	barrier	barrier	NOUN
gs-4132	134	9	(	(	PUNCT
gs-4132	134	10	bbb	bbb	NOUN
gs-4132	134	11	)	)	PUNCT
gs-4132	134	12	challenges	challenge	NOUN
gs-4132	134	13	delivering	deliver	VERB
gs-4132	134	14	therapeutics	therapeutic	NOUN
gs-4132	134	15	to	to	ADP
gs-4132	134	16	the	the	DET
gs-4132	134	17	brain	brain	NOUN
gs-4132	134	18	is	be	AUX
gs-4132	134	19	notoriously	notoriously	ADV
gs-4132	134	20	difficult	difficult	ADJ
gs-4132	134	21	due	due	ADP
gs-4132	134	22	to	to	ADP
gs-4132	134	23	the	the	DET
gs-4132	134	24	bbb	bbb	PROPN
gs-4132	134	25	.	.	PUNCT
gs-4132	135	1	nanoparticles	nanoparticle	NOUN
gs-4132	135	2	must	must	AUX
gs-4132	135	3	be	be	AUX
gs-4132	135	4	small	small	ADJ
gs-4132	135	5	,	,	PUNCT
gs-4132	135	6	stable	stable	ADJ
gs-4132	135	7	,	,	PUNCT
gs-4132	135	8	and	and	CCONJ
gs-4132	135	9	able	able	ADJ
gs-4132	135	10	to	to	PART
gs-4132	135	11	bypass	bypass	VERB
gs-4132	135	12	efflux	efflux	NOUN
gs-4132	135	13	pumps	pump	NOUN
gs-4132	135	14	(	(	PUNCT
gs-4132	135	15	saraiva	saraiva	NOUN
gs-4132	135	16	et	et	PROPN
gs-4132	135	17	al	al	PROPN
gs-4132	135	18	.	.	PROPN
gs-4132	135	19	,	,	PUNCT
gs-4132	135	20	2016	2016	NUM
gs-4132	135	21	)	)	PUNCT
gs-4132	135	22	.	.	PUNCT
gs-4132	136	1	6.2.2	6.2.2	NUM
gs-4132	136	2	exosomes	exosome	NOUN
gs-4132	136	3	for	for	ADP
gs-4132	136	4	neurology	neurology	NOUN
gs-4132	136	5	exosomes	exosome	NOUN
gs-4132	136	6	naturally	naturally	ADV
gs-4132	136	7	cross	cross	VERB
gs-4132	136	8	the	the	DET
gs-4132	136	9	bbb	bbb	PROPN
gs-4132	136	10	.	.	PUNCT
gs-4132	137	1	alvarez	alvarez	PROPN
gs-4132	137	2	-	-	PUNCT
gs-4132	137	3	erviti	erviti	PROPN
gs-4132	137	4	et	et	PROPN
gs-4132	137	5	al	al	PROPN
gs-4132	137	6	.	.	PROPN
gs-4132	138	1	(	(	PUNCT
gs-4132	138	2	2011	2011	NUM
gs-4132	138	3	)	)	PUNCT
gs-4132	138	4	showed	show	VERB
gs-4132	138	5	targeted	targeted	ADJ
gs-4132	138	6	delivery	delivery	NOUN
gs-4132	138	7	of	of	ADP
gs-4132	138	8	sirna	sirna	PROPN
gs-4132	138	9	to	to	ADP
gs-4132	138	10	neurons	neuron	NOUN
gs-4132	138	11	via	via	ADP
gs-4132	138	12	rvg	rvg	NOUN
gs-4132	138	13	-	-	PUNCT
gs-4132	138	14	peptide	peptide	NOUN
gs-4132	138	15	-	-	PUNCT
gs-4132	138	16	modified	modify	VERB
gs-4132	138	17	exosomes	exosome	NOUN
gs-4132	138	18	.	.	PUNCT
gs-4132	139	1	exosomes	exosome	NOUN
gs-4132	139	2	from	from	ADP
gs-4132	139	3	neural	neural	ADJ
gs-4132	139	4	stem	stem	NOUN
gs-4132	139	5	cells	cell	NOUN
gs-4132	139	6	have	have	AUX
gs-4132	139	7	been	be	AUX
gs-4132	139	8	shown	show	VERB
gs-4132	139	9	to	to	PART
gs-4132	139	10	reduce	reduce	VERB
gs-4132	139	11	neuroinflammation	neuroinflammation	NOUN
gs-4132	139	12	and	and	CCONJ
gs-4132	139	13	promote	promote	VERB
gs-4132	139	14	recovery	recovery	NOUN
gs-4132	139	15	in	in	ADP
gs-4132	139	16	stroke	stroke	NOUN
gs-4132	139	17	models	model	NOUN
gs-4132	139	18	(	(	PUNCT
gs-4132	139	19	xin	xin	PROPN
gs-4132	139	20	et	et	PROPN
gs-4132	139	21	al	al	PROPN
gs-4132	139	22	.	.	PROPN
gs-4132	139	23	,	,	PUNCT
gs-4132	139	24	2013	2013	NUM
gs-4132	139	25	)	)	PUNCT
gs-4132	139	26	.	.	PUNCT
gs-4132	140	1	exosomes	exosome	NOUN
gs-4132	140	2	also	also	ADV
gs-4132	140	3	participate	participate	VERB
gs-4132	140	4	in	in	ADP
gs-4132	140	5	disease	disease	NOUN
gs-4132	140	6	propagation	propagation	NOUN
gs-4132	140	7	.	.	PUNCT
gs-4132	141	1	in	in	ADP
gs-4132	141	2	parkinson	parkinson	NOUN
gs-4132	141	3	’s	’s	PART
gs-4132	141	4	disease	disease	NOUN
gs-4132	141	5	,	,	PUNCT
gs-4132	141	6	-synuclein	-synuclein	ADJ
gs-4132	141	7	spreads	spread	NOUN
gs-4132	141	8	via	via	ADP
gs-4132	141	9	exosomes	exosome	NOUN
gs-4132	141	10	(	(	PUNCT
gs-4132	141	11	emmanouilidou	emmanouilidou	PROPN
gs-4132	141	12	et	et	PROPN
gs-4132	141	13	al	al	PROPN
gs-4132	141	14	.	.	PROPN
gs-4132	141	15	,	,	PUNCT
gs-4132	141	16	2010	2010	NUM
gs-4132	141	17	)	)	PUNCT
gs-4132	141	18	.	.	PUNCT
gs-4132	142	1	in	in	ADP
gs-4132	142	2	alzheimer	alzheimer	PROPN
gs-4132	142	3	’s	’s	PART
gs-4132	142	4	disease	disease	NOUN
gs-4132	142	5	,	,	PUNCT
gs-4132	142	6	exosomal	exosomal	ADJ
gs-4132	142	7	tau	tau	PROPN
gs-4132	142	8	and	and	CCONJ
gs-4132	142	9	amyloid	amyloid	NOUN
gs-4132	142	10	contribute	contribute	VERB
gs-4132	142	11	to	to	ADP
gs-4132	142	12	pathology	pathology	NOUN
gs-4132	142	13	(	(	PUNCT
gs-4132	142	14	rajendran	rajendran	PROPN
gs-4132	142	15	et	et	PROPN
gs-4132	142	16	al	al	PROPN
gs-4132	142	17	.	.	PROPN
gs-4132	142	18	,	,	PUNCT
gs-4132	142	19	2006	2006	NUM
gs-4132	142	20	)	)	PUNCT
gs-4132	142	21	.	.	PUNCT
gs-4132	143	1	this	this	DET
gs-4132	143	2	dual	dual	ADJ
gs-4132	143	3	role	role	NOUN
gs-4132	143	4	makes	make	VERB
gs-4132	143	5	exosomes	exosome	NOUN
gs-4132	143	6	both	both	PRON
gs-4132	143	7	biomarkers	biomarker	NOUN
gs-4132	143	8	and	and	CCONJ
gs-4132	143	9	therapeutic	therapeutic	ADJ
gs-4132	143	10	agents	agent	NOUN
gs-4132	143	11	.	.	PUNCT
gs-4132	144	1	georgian	georgian	NOUN
gs-4132	144	2	scientists/	scientists/	NUM
gs-4132	144	3	.	.	PUNCT
gs-4132	145	1	7	7	NUM
gs-4132	145	2	n	n	DET
gs-4132	145	3	4	4	NUM
gs-4132	145	4	,	,	PUNCT
gs-4132	145	5	2025	2025	NUM
gs-4132	145	6	10	10	NUM
gs-4132	145	7	6.2.3	6.2.3	NUM
gs-4132	145	8	liposomes	liposome	NOUN
gs-4132	145	9	in	in	ADP
gs-4132	145	10	neurology	neurology	NOUN
gs-4132	145	11	liposomes	liposome	NOUN
gs-4132	145	12	have	have	AUX
gs-4132	145	13	been	be	AUX
gs-4132	145	14	modified	modify	VERB
gs-4132	145	15	with	with	ADP
gs-4132	145	16	transferrin	transferrin	NOUN
gs-4132	145	17	or	or	CCONJ
gs-4132	145	18	lactoferrin	lactoferrin	NOUN
gs-4132	145	19	ligands	ligand	NOUN
gs-4132	145	20	to	to	PART
gs-4132	145	21	enhance	enhance	VERB
gs-4132	145	22	bbb	bbb	NOUN
gs-4132	145	23	penetration	penetration	NOUN
gs-4132	145	24	(	(	PUNCT
gs-4132	145	25	ulbrich	ulbrich	X
gs-4132	145	26	et	et	PROPN
gs-4132	145	27	al	al	PROPN
gs-4132	145	28	.	.	PROPN
gs-4132	145	29	,	,	PUNCT
gs-4132	145	30	2009	2009	NUM
gs-4132	145	31	)	)	PUNCT
gs-4132	145	32	.	.	PUNCT
gs-4132	146	1	clinical	clinical	ADJ
gs-4132	146	2	studies	study	NOUN
gs-4132	146	3	explore	explore	VERB
gs-4132	146	4	liposomal	liposomal	ADJ
gs-4132	146	5	formulations	formulation	NOUN
gs-4132	146	6	of	of	ADP
gs-4132	146	7	nerve	nerve	NOUN
gs-4132	146	8	growth	growth	NOUN
gs-4132	146	9	factor	factor	NOUN
gs-4132	146	10	and	and	CCONJ
gs-4132	146	11	anti	anti	ADJ
gs-4132	146	12	-	-	ADJ
gs-4132	146	13	inflammatory	inflammatory	ADJ
gs-4132	146	14	drugs	drug	NOUN
gs-4132	146	15	for	for	ADP
gs-4132	146	16	neurodegeneration	neurodegeneration	NOUN
gs-4132	146	17	(	(	PUNCT
gs-4132	146	18	saraiva	saraiva	NOUN
gs-4132	146	19	et	et	PROPN
gs-4132	146	20	al	al	PROPN
gs-4132	146	21	.	.	PROPN
gs-4132	146	22	,	,	PUNCT
gs-4132	146	23	2016	2016	NUM
gs-4132	146	24	)	)	PUNCT
gs-4132	146	25	.	.	PUNCT
gs-4132	147	1	6.3	6.3	NUM
gs-4132	147	2	cardiovascular	cardiovascular	ADJ
gs-4132	147	3	and	and	CCONJ
gs-4132	147	4	metabolic	metabolic	NOUN
gs-4132	147	5	diseases	disease	NOUN
gs-4132	147	6	6.3.1	6.3.1	NUM
gs-4132	147	7	exosomes	exosome	NOUN
gs-4132	147	8	in	in	ADP
gs-4132	147	9	cardiac	cardiac	ADJ
gs-4132	147	10	repair	repair	NOUN
gs-4132	147	11	exosomes	exosome	NOUN
gs-4132	147	12	derived	derive	VERB
gs-4132	147	13	from	from	ADP
gs-4132	147	14	mesenchymal	mesenchymal	ADJ
gs-4132	147	15	stem	stem	NOUN
gs-4132	147	16	cells	cell	NOUN
gs-4132	147	17	or	or	CCONJ
gs-4132	147	18	cardiac	cardiac	ADJ
gs-4132	147	19	progenitor	progenitor	NOUN
gs-4132	147	20	cells	cell	NOUN
gs-4132	147	21	can	can	AUX
gs-4132	147	22	repair	repair	VERB
gs-4132	147	23	ischemic	ischemic	ADJ
gs-4132	147	24	myocardium	myocardium	NOUN
gs-4132	147	25	by	by	ADP
gs-4132	147	26	enhancing	enhance	VERB
gs-4132	147	27	angiogenesis	angiogenesis	NOUN
gs-4132	147	28	,	,	PUNCT
gs-4132	147	29	reducing	reduce	VERB
gs-4132	147	30	apoptosis	apoptosis	NOUN
gs-4132	147	31	,	,	PUNCT
gs-4132	147	32	and	and	CCONJ
gs-4132	147	33	modulating	modulate	VERB
gs-4132	147	34	immune	immune	ADJ
gs-4132	147	35	cells	cell	NOUN
gs-4132	147	36	(	(	PUNCT
gs-4132	147	37	ibrahim	ibrahim	NOUN
gs-4132	147	38	and	and	CCONJ
gs-4132	147	39	marbán	marbán	ADJ
gs-4132	147	40	,	,	PUNCT
gs-4132	147	41	2016	2016	NUM
gs-4132	147	42	)	)	PUNCT
gs-4132	147	43	.	.	PUNCT
gs-4132	148	1	exosomal	exosomal	ADJ
gs-4132	148	2	micrornas	microrna	NOUN
gs-4132	148	3	,	,	PUNCT
gs-4132	148	4	such	such	ADJ
gs-4132	148	5	as	as	ADP
gs-4132	148	6	mir21	mir21	NOUN
gs-4132	148	7	and	and	CCONJ
gs-4132	148	8	mir-126	mir-126	NOUN
gs-4132	148	9	,	,	PUNCT
gs-4132	148	10	are	be	AUX
gs-4132	148	11	particularly	particularly	ADV
gs-4132	148	12	implicated	implicate	VERB
gs-4132	148	13	in	in	ADP
gs-4132	148	14	cardioprotection	cardioprotection	NOUN
gs-4132	148	15	(	(	PUNCT
gs-4132	148	16	vicencio	vicencio	PROPN
gs-4132	148	17	et	et	PROPN
gs-4132	148	18	al	al	PROPN
gs-4132	148	19	.	.	PROPN
gs-4132	148	20	,	,	PUNCT
gs-4132	148	21	2015	2015	NUM
gs-4132	148	22	)	)	PUNCT
gs-4132	148	23	.	.	PUNCT
gs-4132	149	1	6.3.2	6.3.2	NUM
gs-4132	149	2	nanoparticles	nanoparticle	NOUN
gs-4132	149	3	for	for	ADP
gs-4132	149	4	cardiovascular	cardiovascular	ADJ
gs-4132	149	5	delivery	delivery	NOUN
gs-4132	149	6	liposomes	liposome	NOUN
gs-4132	149	7	and	and	CCONJ
gs-4132	149	8	polymeric	polymeric	ADJ
gs-4132	149	9	nanoparticles	nanoparticle	NOUN
gs-4132	149	10	have	have	AUX
gs-4132	149	11	been	be	AUX
gs-4132	149	12	tested	test	VERB
gs-4132	149	13	for	for	ADP
gs-4132	149	14	targeted	target	VERB
gs-4132	149	15	delivery	delivery	NOUN
gs-4132	149	16	of	of	ADP
gs-4132	149	17	anti	anti	ADJ
gs-4132	149	18	-	-	ADJ
gs-4132	149	19	thrombotic	thrombotic	ADJ
gs-4132	149	20	drugs	drug	NOUN
gs-4132	149	21	,	,	PUNCT
gs-4132	149	22	sirnas	sirna	NOUN
gs-4132	149	23	,	,	PUNCT
gs-4132	149	24	and	and	CCONJ
gs-4132	149	25	antioxidants	antioxidant	NOUN
gs-4132	149	26	.	.	PUNCT
gs-4132	150	1	lipid	lipid	ADJ
gs-4132	150	2	nanoparticles	nanoparticle	NOUN
gs-4132	150	3	have	have	AUX
gs-4132	150	4	recently	recently	ADV
gs-4132	150	5	been	be	AUX
gs-4132	150	6	developed	develop	VERB
gs-4132	150	7	for	for	ADP
gs-4132	150	8	mrna	mrna	PROPN
gs-4132	150	9	delivery	delivery	NOUN
gs-4132	150	10	in	in	ADP
gs-4132	150	11	cardiovascular	cardiovascular	ADJ
gs-4132	150	12	disease	disease	NOUN
gs-4132	150	13	models	model	NOUN
gs-4132	150	14	(	(	PUNCT
gs-4132	150	15	gan	gan	VERB
gs-4132	150	16	et	et	PROPN
gs-4132	150	17	al	al	PROPN
gs-4132	150	18	.	.	PROPN
gs-4132	150	19	,	,	PUNCT
gs-4132	150	20	2021	2021	NUM
gs-4132	150	21	)	)	PUNCT
gs-4132	150	22	.	.	PUNCT
gs-4132	151	1	6.4	6.4	NUM
gs-4132	151	2	infectious	infectious	ADJ
gs-4132	151	3	diseases	disease	NOUN
gs-4132	151	4	6.4.1	6.4.1	NUM
gs-4132	151	5	exosomes	exosome	NOUN
gs-4132	151	6	in	in	ADP
gs-4132	151	7	immunity	immunity	NOUN
gs-4132	151	8	and	and	CCONJ
gs-4132	151	9	vaccination	vaccination	NOUN
gs-4132	151	10	exosomes	exosome	NOUN
gs-4132	151	11	derived	derive	VERB
gs-4132	151	12	from	from	ADP
gs-4132	151	13	antigen	antigen	NOUN
gs-4132	151	14	-	-	PUNCT
gs-4132	151	15	presenting	present	VERB
gs-4132	151	16	cells	cell	NOUN
gs-4132	151	17	(	(	PUNCT
gs-4132	151	18	apcs	apc	NOUN
gs-4132	151	19	)	)	PUNCT
gs-4132	151	20	carry	carry	VERB
gs-4132	151	21	mhc	mhc	PROPN
gs-4132	151	22	-	-	PUNCT
gs-4132	151	23	peptide	peptide	NOUN
gs-4132	151	24	complexes	complex	NOUN
gs-4132	151	25	that	that	PRON
gs-4132	151	26	can	can	AUX
gs-4132	151	27	stimulate	stimulate	VERB
gs-4132	151	28	t	t	NOUN
gs-4132	151	29	cells	cell	NOUN
gs-4132	151	30	.	.	PUNCT
gs-4132	152	1	clinical	clinical	ADJ
gs-4132	152	2	trials	trial	NOUN
gs-4132	152	3	have	have	AUX
gs-4132	152	4	tested	test	VERB
gs-4132	152	5	dendritic	dendritic	ADJ
gs-4132	152	6	-	-	PUNCT
gs-4132	152	7	cell	cell	NOUN
gs-4132	152	8	derived	derive	VERB
gs-4132	152	9	exosomes	exosome	NOUN
gs-4132	152	10	as	as	ADP
gs-4132	152	11	cancer	cancer	NOUN
gs-4132	152	12	vaccines	vaccine	NOUN
gs-4132	152	13	,	,	PUNCT
gs-4132	152	14	and	and	CCONJ
gs-4132	152	15	similar	similar	ADJ
gs-4132	152	16	approaches	approach	NOUN
gs-4132	152	17	are	be	AUX
gs-4132	152	18	being	be	AUX
gs-4132	152	19	explored	explore	VERB
gs-4132	152	20	for	for	ADP
gs-4132	152	21	infectious	infectious	ADJ
gs-4132	152	22	diseases	disease	NOUN
gs-4132	152	23	(	(	PUNCT
gs-4132	152	24	viaud	viaud	NOUN
gs-4132	152	25	et	et	PROPN
gs-4132	152	26	al	al	PROPN
gs-4132	152	27	.	.	PROPN
gs-4132	152	28	,	,	PUNCT
gs-4132	152	29	2010	2010	NUM
gs-4132	152	30	)	)	PUNCT
gs-4132	152	31	.	.	PUNCT
gs-4132	153	1	pathogens	pathogen	NOUN
gs-4132	153	2	also	also	ADV
gs-4132	153	3	hijack	hijack	VERB
gs-4132	153	4	exosome	exosome	PROPN
gs-4132	153	5	pathways	pathway	NOUN
gs-4132	153	6	.	.	PUNCT
gs-4132	154	1	hiv	hiv	PROPN
gs-4132	154	2	incorporates	incorporate	VERB
gs-4132	154	3	viral	viral	ADJ
gs-4132	154	4	rna	rna	NOUN
gs-4132	154	5	and	and	CCONJ
gs-4132	154	6	proteins	protein	NOUN
gs-4132	154	7	into	into	ADP
gs-4132	154	8	exosomes	exosome	NOUN
gs-4132	154	9	,	,	PUNCT
gs-4132	154	10	aiding	aid	VERB
gs-4132	154	11	viral	viral	ADJ
gs-4132	154	12	spread	spread	NOUN
gs-4132	154	13	(	(	PUNCT
gs-4132	154	14	madison	madison	NOUN
gs-4132	154	15	and	and	CCONJ
gs-4132	154	16	okeoma	okeoma	NOUN
gs-4132	154	17	,	,	PUNCT
gs-4132	154	18	2015	2015	NUM
gs-4132	154	19	)	)	PUNCT
gs-4132	154	20	.	.	PUNCT
gs-4132	155	1	this	this	DET
gs-4132	155	2	understanding	understanding	NOUN
gs-4132	155	3	opens	open	VERB
gs-4132	155	4	avenues	avenue	NOUN
gs-4132	155	5	for	for	ADP
gs-4132	155	6	exosome	exosome	NOUN
gs-4132	155	7	-	-	PUNCT
gs-4132	155	8	based	base	VERB
gs-4132	155	9	antiviral	antiviral	ADJ
gs-4132	155	10	strategies	strategy	NOUN
gs-4132	155	11	.	.	PUNCT
gs-4132	156	1	6.4.2	6.4.2	NUM
gs-4132	156	2	liposomes	liposome	NOUN
gs-4132	156	3	and	and	CCONJ
gs-4132	156	4	nanoparticles	nanoparticle	NOUN
gs-4132	156	5	in	in	ADP
gs-4132	156	6	vaccines	vaccine	NOUN
gs-4132	156	7	liposomes	liposome	NOUN
gs-4132	156	8	are	be	AUX
gs-4132	156	9	established	establish	VERB
gs-4132	156	10	as	as	ADP
gs-4132	156	11	vaccine	vaccine	NOUN
gs-4132	156	12	adjuvants	adjuvant	NOUN
gs-4132	156	13	.	.	PUNCT
gs-4132	157	1	virosomes	virosome	NOUN
gs-4132	157	2	(	(	PUNCT
gs-4132	157	3	virus	virus	NOUN
gs-4132	157	4	-	-	PUNCT
gs-4132	157	5	like	like	ADJ
gs-4132	157	6	liposomes	liposome	NOUN
gs-4132	157	7	incorporating	incorporate	VERB
gs-4132	157	8	viral	viral	ADJ
gs-4132	157	9	proteins	protein	NOUN
gs-4132	157	10	)	)	PUNCT
gs-4132	157	11	are	be	AUX
gs-4132	157	12	used	use	VERB
gs-4132	157	13	in	in	ADP
gs-4132	157	14	influenza	influenza	ADJ
gs-4132	157	15	vaccines	vaccine	NOUN
gs-4132	157	16	(	(	PUNCT
gs-4132	157	17	mozafari	mozafari	NOUN
gs-4132	157	18	,	,	PUNCT
gs-4132	157	19	2005	2005	NUM
gs-4132	157	20	)	)	PUNCT
gs-4132	157	21	.	.	PUNCT
gs-4132	158	1	the	the	DET
gs-4132	158	2	recent	recent	ADJ
gs-4132	158	3	success	success	NOUN
gs-4132	158	4	of	of	ADP
gs-4132	158	5	lipid	lipid	ADJ
gs-4132	158	6	nanoparticle	nanoparticle	NOUN
gs-4132	158	7	(	(	PUNCT
gs-4132	158	8	lnp)-based	lnp)-base	VERB
gs-4132	158	9	mrna	mrna	NOUN
gs-4132	158	10	vaccines	vaccine	NOUN
gs-4132	158	11	for	for	ADP
gs-4132	158	12	covid-19	covid-19	PROPN
gs-4132	158	13	(	(	PUNCT
gs-4132	158	14	sahin	sahin	PROPN
gs-4132	158	15	et	et	PROPN
gs-4132	158	16	al	al	PROPN
gs-4132	158	17	.	.	PROPN
gs-4132	158	18	,	,	PUNCT
gs-4132	158	19	2020	2020	NUM
gs-4132	158	20	)	)	PUNCT
gs-4132	158	21	underscores	underscore	VERB
gs-4132	158	22	the	the	DET
gs-4132	158	23	power	power	NOUN
gs-4132	158	24	of	of	ADP
gs-4132	158	25	synthetic	synthetic	ADJ
gs-4132	158	26	nanoparticles	nanoparticle	NOUN
gs-4132	158	27	in	in	ADP
gs-4132	158	28	infectious	infectious	ADJ
gs-4132	158	29	disease	disease	NOUN
gs-4132	158	30	therapy	therapy	NOUN
gs-4132	158	31	.	.	PUNCT
gs-4132	159	1	6.5	6.5	NUM
gs-4132	159	2	regenerative	regenerative	ADJ
gs-4132	159	3	medicine	medicine	NOUN
gs-4132	159	4	6.5.1	6.5.1	NUM
gs-4132	159	5	exosomes	exosome	NOUN
gs-4132	159	6	from	from	ADP
gs-4132	159	7	stem	stem	NOUN
gs-4132	159	8	cells	cell	NOUN
gs-4132	159	9	stem	stem	VERB
gs-4132	159	10	cell	cell	NOUN
gs-4132	159	11	-	-	PUNCT
gs-4132	159	12	derived	derive	VERB
gs-4132	159	13	exosomes	exosome	NOUN
gs-4132	159	14	are	be	AUX
gs-4132	159	15	among	among	ADP
gs-4132	159	16	the	the	DET
gs-4132	159	17	most	most	ADV
gs-4132	159	18	promising	promising	ADJ
gs-4132	159	19	regenerative	regenerative	ADJ
gs-4132	159	20	tools	tool	NOUN
gs-4132	159	21	.	.	PUNCT
gs-4132	160	1	mscderived	mscderive	VERB
gs-4132	160	2	exosomes	exosome	NOUN
gs-4132	160	3	enhance	enhance	VERB
gs-4132	160	4	angiogenesis	angiogenesis	NOUN
gs-4132	160	5	,	,	PUNCT
gs-4132	160	6	modulate	modulate	VERB
gs-4132	160	7	macrophage	macrophage	ADJ
gs-4132	160	8	polarization	polarization	NOUN
gs-4132	160	9	,	,	PUNCT
gs-4132	160	10	and	and	CCONJ
gs-4132	160	11	reduce	reduce	VERB
gs-4132	160	12	georgian	georgian	PROPN
gs-4132	160	13	scientists/	scientists/	NUM
gs-4132	160	14	.	.	PUNCT
gs-4132	161	1	7	7	NUM
gs-4132	161	2	n	n	DET
gs-4132	161	3	4	4	NUM
gs-4132	161	4	,	,	PUNCT
gs-4132	161	5	2025	2025	NUM
gs-4132	161	6	11	11	NUM
gs-4132	161	7	fibrosis	fibrosis	NOUN
gs-4132	161	8	in	in	ADP
gs-4132	161	9	models	model	NOUN
gs-4132	161	10	of	of	ADP
gs-4132	161	11	myocardial	myocardial	ADJ
gs-4132	161	12	infarction	infarction	NOUN
gs-4132	161	13	,	,	PUNCT
gs-4132	161	14	liver	liver	NOUN
gs-4132	161	15	injury	injury	NOUN
gs-4132	161	16	,	,	PUNCT
gs-4132	161	17	and	and	CCONJ
gs-4132	161	18	kidney	kidney	NOUN
gs-4132	161	19	disease	disease	NOUN
gs-4132	161	20	(	(	PUNCT
gs-4132	161	21	phinney	phinney	NOUN
gs-4132	161	22	and	and	CCONJ
gs-4132	161	23	pittenger	pittenger	PROPN
gs-4132	161	24	,	,	PUNCT
gs-4132	161	25	2017	2017	NUM
gs-4132	161	26	)	)	PUNCT
gs-4132	161	27	.	.	PUNCT
gs-4132	162	1	6.5.2	6.5.2	NUM
gs-4132	162	2	liposomes	liposome	NOUN
gs-4132	162	3	and	and	CCONJ
gs-4132	162	4	biomaterials	biomaterial	NOUN
gs-4132	162	5	liposomes	liposome	NOUN
gs-4132	162	6	can	can	AUX
gs-4132	162	7	encapsulate	encapsulate	VERB
gs-4132	162	8	growth	growth	NOUN
gs-4132	162	9	factors	factor	NOUN
gs-4132	162	10	(	(	PUNCT
gs-4132	162	11	vegf	vegf	PROPN
gs-4132	162	12	,	,	PUNCT
gs-4132	162	13	fgf	fgf	PROPN
gs-4132	162	14	)	)	PUNCT
gs-4132	162	15	and	and	CCONJ
gs-4132	162	16	be	be	AUX
gs-4132	162	17	incorporated	incorporate	VERB
gs-4132	162	18	into	into	ADP
gs-4132	162	19	biomaterial	biomaterial	ADJ
gs-4132	162	20	scaffolds	scaffold	NOUN
gs-4132	162	21	for	for	ADP
gs-4132	162	22	tissue	tissue	NOUN
gs-4132	162	23	engineering	engineering	NOUN
gs-4132	162	24	.	.	PUNCT
gs-4132	163	1	controlled	control	VERB
gs-4132	163	2	release	release	NOUN
gs-4132	163	3	from	from	ADP
gs-4132	163	4	liposome	liposome	NOUN
gs-4132	163	5	–	–	PUNCT
gs-4132	163	6	hydrogel	hydrogel	NOUN
gs-4132	163	7	composites	composite	NOUN
gs-4132	163	8	accelerates	accelerate	VERB
gs-4132	163	9	wound	wound	ADJ
gs-4132	163	10	healing	healing	NOUN
gs-4132	163	11	and	and	CCONJ
gs-4132	163	12	bone	bone	NOUN
gs-4132	163	13	regeneration	regeneration	NOUN
gs-4132	163	14	(	(	PUNCT
gs-4132	163	15	wang	wang	PROPN
gs-4132	163	16	et	et	PROPN
gs-4132	163	17	al	al	PROPN
gs-4132	163	18	.	.	PROPN
gs-4132	163	19	,	,	PUNCT
gs-4132	163	20	2017	2017	NUM
gs-4132	163	21	)	)	PUNCT
gs-4132	163	22	.	.	PUNCT
gs-4132	164	1	6.6	6.6	NUM
gs-4132	164	2	clinical	clinical	ADJ
gs-4132	164	3	trials	trial	NOUN
gs-4132	164	4	landscape	landscape	NOUN
gs-4132	164	5	exosomes	exosome	NOUN
gs-4132	164	6	:	:	PUNCT
gs-4132	164	7	clinical	clinical	ADJ
gs-4132	164	8	trials	trial	NOUN
gs-4132	164	9	are	be	AUX
gs-4132	164	10	ongoing	ongoing	ADJ
gs-4132	164	11	for	for	ADP
gs-4132	164	12	cancer	cancer	NOUN
gs-4132	164	13	,	,	PUNCT
gs-4132	164	14	covid-19	covid-19	PROPN
gs-4132	164	15	,	,	PUNCT
gs-4132	164	16	and	and	CCONJ
gs-4132	164	17	regenerative	regenerative	ADJ
gs-4132	164	18	medicine	medicine	NOUN
gs-4132	164	19	(	(	PUNCT
gs-4132	164	20	clinicaltrials.gov	clinicaltrials.gov	NOUN
gs-4132	164	21	identifiers	identifier	NOUN
gs-4132	164	22	:	:	PUNCT
gs-4132	164	23	nct03608631	nct03608631	ADJ
gs-4132	164	24	,	,	PUNCT
gs-4132	164	25	nct04602442	nct04602442	NOUN
gs-4132	164	26	)	)	PUNCT
gs-4132	164	27	.	.	PUNCT
gs-4132	165	1	most	most	ADJ
gs-4132	165	2	focus	focus	VERB
gs-4132	165	3	on	on	ADP
gs-4132	165	4	mscderived	mscderived	ADJ
gs-4132	165	5	exosomes	exosome	NOUN
gs-4132	165	6	for	for	ADP
gs-4132	165	7	inflammatory	inflammatory	ADJ
gs-4132	165	8	or	or	CCONJ
gs-4132	165	9	degenerative	degenerative	ADJ
gs-4132	165	10	diseases	disease	NOUN
gs-4132	165	11	.	.	PUNCT
gs-4132	166	1	liposomes	liposome	NOUN
gs-4132	166	2	:	:	PUNCT
gs-4132	166	3	numerous	numerous	ADJ
gs-4132	166	4	liposomal	liposomal	ADJ
gs-4132	166	5	drugs	drug	NOUN
gs-4132	166	6	are	be	AUX
gs-4132	166	7	already	already	ADV
gs-4132	166	8	fda	fda	PROPN
gs-4132	166	9	-	-	PUNCT
gs-4132	166	10	approved	approve	VERB
gs-4132	166	11	,	,	PUNCT
gs-4132	166	12	with	with	ADP
gs-4132	166	13	ongoing	ongoing	ADJ
gs-4132	166	14	trials	trial	NOUN
gs-4132	166	15	for	for	ADP
gs-4132	166	16	improved	improved	ADJ
gs-4132	166	17	formulations	formulation	NOUN
gs-4132	166	18	and	and	CCONJ
gs-4132	166	19	novel	novel	ADJ
gs-4132	166	20	agents	agent	NOUN
gs-4132	166	21	.	.	PUNCT
gs-4132	167	1	7	7	X
gs-4132	167	2	.	.	X
gs-4132	167	3	comparative	comparative	ADJ
gs-4132	167	4	analysis	analysis	NOUN
gs-4132	167	5	of	of	ADP
gs-4132	167	6	exosomes	exosome	NOUN
gs-4132	167	7	,	,	PUNCT
gs-4132	167	8	liposomes	liposome	NOUN
gs-4132	167	9	,	,	PUNCT
gs-4132	167	10	and	and	CCONJ
gs-4132	167	11	other	other	ADJ
gs-4132	167	12	nanoparticle	nanoparticle	NOUN
gs-4132	167	13	systems	system	NOUN
gs-4132	167	14	7.1	7.1	NUM
gs-4132	167	15	biocompatibility	biocompatibility	NOUN
gs-4132	167	16	and	and	CCONJ
gs-4132	167	17	immunogenicity	immunogenicity	NOUN
gs-4132	167	18	exosomes	exosome	NOUN
gs-4132	167	19	,	,	PUNCT
gs-4132	167	20	derived	derive	VERB
gs-4132	167	21	from	from	ADP
gs-4132	167	22	endogenous	endogenous	ADJ
gs-4132	167	23	cellular	cellular	ADJ
gs-4132	167	24	processes	process	NOUN
gs-4132	167	25	,	,	PUNCT
gs-4132	167	26	are	be	AUX
gs-4132	167	27	naturally	naturally	ADV
gs-4132	167	28	biocompatible	biocompatible	ADJ
gs-4132	167	29	and	and	CCONJ
gs-4132	167	30	typically	typically	ADV
gs-4132	167	31	display	display	VERB
gs-4132	167	32	low	low	ADJ
gs-4132	167	33	immunogenicity	immunogenicity	NOUN
gs-4132	167	34	when	when	SCONJ
gs-4132	167	35	used	use	VERB
gs-4132	167	36	autologously	autologously	ADV
gs-4132	167	37	(	(	PUNCT
gs-4132	167	38	lener	lener	PROPN
gs-4132	167	39	et	et	PROPN
gs-4132	167	40	al	al	PROPN
gs-4132	167	41	.	.	PROPN
gs-4132	167	42	,	,	PUNCT
gs-4132	167	43	2015	2015	NUM
gs-4132	167	44	)	)	PUNCT
gs-4132	167	45	.	.	PUNCT
gs-4132	168	1	their	their	PRON
gs-4132	168	2	membranes	membrane	NOUN
gs-4132	168	3	carry	carry	VERB
gs-4132	168	4	self	self	NOUN
gs-4132	168	5	-	-	PUNCT
gs-4132	168	6	markers	marker	NOUN
gs-4132	168	7	such	such	ADJ
gs-4132	168	8	as	as	ADP
gs-4132	168	9	cd47	cd47	PROPN
gs-4132	168	10	(	(	PUNCT
gs-4132	168	11	“	"	PUNCT
gs-4132	168	12	do	do	AUX
gs-4132	168	13	n’t	not	PART
gs-4132	168	14	eat	eat	VERB
gs-4132	168	15	me	i	PRON
gs-4132	168	16	”	"	PUNCT
gs-4132	168	17	signal	signal	NOUN
gs-4132	168	18	)	)	PUNCT
gs-4132	168	19	,	,	PUNCT
gs-4132	168	20	which	which	PRON
gs-4132	168	21	protect	protect	VERB
gs-4132	168	22	them	they	PRON
gs-4132	168	23	from	from	ADP
gs-4132	168	24	phagocytosis	phagocytosis	NOUN
gs-4132	168	25	(	(	PUNCT
gs-4132	168	26	morrissey	morrissey	PROPN
gs-4132	168	27	et	et	PROPN
gs-4132	168	28	al	al	PROPN
gs-4132	168	29	.	.	PROPN
gs-4132	168	30	,	,	PUNCT
gs-4132	168	31	2020	2020	NUM
gs-4132	168	32	)	)	PUNCT
gs-4132	168	33	.	.	PUNCT
gs-4132	169	1	however	however	ADV
gs-4132	169	2	,	,	PUNCT
gs-4132	169	3	exosomes	exosome	NOUN
gs-4132	169	4	from	from	ADP
gs-4132	169	5	allogeneic	allogeneic	ADJ
gs-4132	169	6	sources	source	NOUN
gs-4132	169	7	may	may	AUX
gs-4132	169	8	induce	induce	VERB
gs-4132	169	9	immune	immune	ADJ
gs-4132	169	10	responses	response	NOUN
gs-4132	169	11	,	,	PUNCT
gs-4132	169	12	particularly	particularly	ADV
gs-4132	169	13	if	if	SCONJ
gs-4132	169	14	they	they	PRON
gs-4132	169	15	contain	contain	VERB
gs-4132	169	16	major	major	ADJ
gs-4132	169	17	histocompatibility	histocompatibility	NOUN
gs-4132	169	18	complex	complex	NOUN
gs-4132	169	19	(	(	PUNCT
gs-4132	169	20	mhc	mhc	PROPN
gs-4132	169	21	)	)	PUNCT
gs-4132	169	22	molecules	molecule	NOUN
gs-4132	169	23	(	(	PUNCT
gs-4132	169	24	dai	dai	PROPN
gs-4132	169	25	et	et	PROPN
gs-4132	169	26	al	al	PROPN
gs-4132	169	27	.	.	PROPN
gs-4132	169	28	,	,	PUNCT
gs-4132	169	29	2008	2008	NUM
gs-4132	169	30	)	)	PUNCT
gs-4132	169	31	.	.	PUNCT
gs-4132	170	1	liposomes	liposome	NOUN
gs-4132	170	2	,	,	PUNCT
gs-4132	170	3	while	while	SCONJ
gs-4132	170	4	well	well	ADV
gs-4132	170	5	tolerated	tolerate	VERB
gs-4132	170	6	in	in	ADP
gs-4132	170	7	most	most	ADJ
gs-4132	170	8	clinical	clinical	ADJ
gs-4132	170	9	contexts	contexts	NOUN
gs-4132	170	10	,	,	PUNCT
gs-4132	170	11	can	can	AUX
gs-4132	170	12	trigger	trigger	VERB
gs-4132	170	13	complement	complement	NOUN
gs-4132	170	14	activation	activation	NOUN
gs-4132	170	15	-	-	PUNCT
gs-4132	170	16	related	relate	VERB
gs-4132	170	17	pseudoallergy	pseudoallergy	NOUN
gs-4132	170	18	(	(	PUNCT
gs-4132	170	19	carpa	carpa	PROPN
gs-4132	170	20	)	)	PUNCT
gs-4132	170	21	,	,	PUNCT
gs-4132	170	22	especially	especially	ADV
gs-4132	170	23	in	in	ADP
gs-4132	170	24	non	non	ADJ
gs-4132	170	25	-	-	ADJ
gs-4132	170	26	pegylated	pegylated	ADJ
gs-4132	170	27	formulations	formulation	NOUN
gs-4132	170	28	(	(	PUNCT
gs-4132	170	29	szebeni	szebeni	NOUN
gs-4132	170	30	,	,	PUNCT
gs-4132	170	31	2005	2005	NUM
gs-4132	170	32	)	)	PUNCT
gs-4132	170	33	.	.	PUNCT
gs-4132	171	1	pegylation	pegylation	NOUN
gs-4132	171	2	reduces	reduce	VERB
gs-4132	171	3	clearance	clearance	NOUN
gs-4132	171	4	but	but	CCONJ
gs-4132	171	5	can	can	AUX
gs-4132	171	6	cause	cause	VERB
gs-4132	171	7	anti	anti	ADJ
gs-4132	171	8	-	-	ADJ
gs-4132	171	9	peg	peg	ADJ
gs-4132	171	10	antibody	antibody	NOUN
gs-4132	171	11	formation	formation	NOUN
gs-4132	171	12	in	in	ADP
gs-4132	171	13	some	some	DET
gs-4132	171	14	patients	patient	NOUN
gs-4132	171	15	,	,	PUNCT
gs-4132	171	16	leading	lead	VERB
gs-4132	171	17	to	to	ADP
gs-4132	171	18	hypersensitivity	hypersensitivity	NOUN
gs-4132	171	19	(	(	PUNCT
gs-4132	171	20	garay	garay	NOUN
gs-4132	171	21	et	et	NOUN
gs-4132	171	22	al	al	PROPN
gs-4132	171	23	.	.	PROPN
gs-4132	171	24	,	,	PUNCT
gs-4132	171	25	2012	2012	NUM
gs-4132	171	26	)	)	PUNCT
gs-4132	171	27	.	.	PUNCT
gs-4132	172	1	case	case	NOUN
gs-4132	172	2	example	example	NOUN
gs-4132	172	3	:	:	PUNCT
gs-4132	172	4	exosomes	exosome	NOUN
gs-4132	172	5	:	:	PUNCT
gs-4132	172	6	msc	msc	NOUN
gs-4132	172	7	-	-	PUNCT
gs-4132	172	8	derived	derive	VERB
gs-4132	172	9	exosomes	exosome	NOUN
gs-4132	172	10	have	have	AUX
gs-4132	172	11	been	be	AUX
gs-4132	172	12	infused	infuse	VERB
gs-4132	172	13	in	in	ADP
gs-4132	172	14	clinical	clinical	ADJ
gs-4132	172	15	trials	trial	NOUN
gs-4132	172	16	for	for	ADP
gs-4132	172	17	graftversus	graftversus	NOUN
gs-4132	172	18	-	-	PUNCT
gs-4132	172	19	host	host	NOUN
gs-4132	172	20	disease	disease	NOUN
gs-4132	172	21	with	with	ADP
gs-4132	172	22	no	no	DET
gs-4132	172	23	severe	severe	ADJ
gs-4132	172	24	adverse	adverse	ADJ
gs-4132	172	25	effects	effect	NOUN
gs-4132	172	26	(	(	PUNCT
gs-4132	172	27	kordelas	kordela	NOUN
gs-4132	172	28	et	et	PROPN
gs-4132	172	29	al	al	PROPN
gs-4132	172	30	.	.	PROPN
gs-4132	172	31	,	,	PUNCT
gs-4132	172	32	2014	2014	NUM
gs-4132	172	33	)	)	PUNCT
gs-4132	172	34	.	.	PUNCT
gs-4132	173	1	liposomes	liposome	NOUN
gs-4132	173	2	:	:	PUNCT
gs-4132	173	3	doxil	doxil	PROPN
gs-4132	173	4	®	®	PROPN
gs-4132	173	5	,	,	PUNCT
gs-4132	173	6	despite	despite	SCONJ
gs-4132	173	7	its	its	PRON
gs-4132	173	8	therapeutic	therapeutic	ADJ
gs-4132	173	9	benefits	benefit	NOUN
gs-4132	173	10	,	,	PUNCT
gs-4132	173	11	occasionally	occasionally	ADV
gs-4132	173	12	induces	induce	VERB
gs-4132	173	13	hypersensitivity	hypersensitivity	NOUN
gs-4132	173	14	reactions	reaction	NOUN
gs-4132	173	15	due	due	ADP
gs-4132	173	16	to	to	ADP
gs-4132	173	17	complement	complement	VERB
gs-4132	173	18	activation	activation	NOUN
gs-4132	173	19	(	(	PUNCT
gs-4132	173	20	szebeni	szebeni	NOUN
gs-4132	173	21	,	,	PUNCT
gs-4132	173	22	2005	2005	NUM
gs-4132	173	23	)	)	PUNCT
gs-4132	173	24	.	.	PUNCT
gs-4132	174	1	conclusion	conclusion	NOUN
gs-4132	174	2	:	:	PUNCT
gs-4132	174	3	exosomes	exosome	NOUN
gs-4132	174	4	hold	hold	VERB
gs-4132	174	5	an	an	DET
gs-4132	174	6	edge	edge	NOUN
gs-4132	174	7	in	in	ADP
gs-4132	174	8	immunotolerance	immunotolerance	NOUN
gs-4132	174	9	,	,	PUNCT
gs-4132	174	10	but	but	CCONJ
gs-4132	174	11	standardization	standardization	NOUN
gs-4132	174	12	and	and	CCONJ
gs-4132	174	13	donor	donor	NOUN
gs-4132	174	14	source	source	NOUN
gs-4132	174	15	remain	remain	VERB
gs-4132	174	16	critical	critical	ADJ
gs-4132	174	17	.	.	PUNCT
gs-4132	175	1	7.2	7.2	NUM
gs-4132	175	2	targeting	targeting	NOUN
gs-4132	175	3	and	and	CCONJ
gs-4132	175	4	biodistribution	biodistribution	NOUN
gs-4132	175	5	exosomes	exosome	NOUN
gs-4132	175	6	display	display	VERB
gs-4132	175	7	intrinsic	intrinsic	ADJ
gs-4132	175	8	targeting	targeting	NOUN
gs-4132	175	9	capabilities	capability	NOUN
gs-4132	175	10	mediated	mediate	VERB
gs-4132	175	11	by	by	ADP
gs-4132	175	12	integrins	integrin	NOUN
gs-4132	175	13	,	,	PUNCT
gs-4132	175	14	tetraspanins	tetraspanin	NOUN
gs-4132	175	15	,	,	PUNCT
gs-4132	175	16	and	and	CCONJ
gs-4132	175	17	lipid	lipid	NOUN
gs-4132	175	18	composition	composition	NOUN
gs-4132	175	19	.	.	PUNCT
gs-4132	176	1	hoshino	hoshino	PROPN
gs-4132	176	2	et	et	PROPN
gs-4132	176	3	al	al	PROPN
gs-4132	176	4	.	.	PROPN
gs-4132	177	1	(	(	PUNCT
gs-4132	177	2	2015	2015	NUM
gs-4132	177	3	)	)	PUNCT
gs-4132	177	4	demonstrated	demonstrate	VERB
gs-4132	177	5	that	that	SCONJ
gs-4132	177	6	exosomal	exosomal	ADJ
gs-4132	177	7	integrins	integrin	NOUN
gs-4132	177	8	determine	determine	VERB
gs-4132	177	9	organotropic	organotropic	ADJ
gs-4132	177	10	metastasis	metastasis	NOUN
gs-4132	177	11	:	:	PUNCT
gs-4132	177	12	4	4	NUM
gs-4132	177	13	integrin	integrin	NOUN
gs-4132	177	14	-	-	PUNCT
gs-4132	177	15	rich	rich	ADJ
gs-4132	177	16	exosomes	exosome	NOUN
gs-4132	177	17	promote	promote	VERB
gs-4132	177	18	lung	lung	NOUN
gs-4132	177	19	metastasis	metastasis	NOUN
gs-4132	177	20	,	,	PUNCT
gs-4132	177	21	georgian	georgian	NOUN
gs-4132	177	22	scientists/	scientists/	NUM
gs-4132	177	23	.	.	PUNCT
gs-4132	178	1	7	7	NUM
gs-4132	178	2	n	n	DET
gs-4132	178	3	4	4	NUM
gs-4132	178	4	,	,	PUNCT
gs-4132	178	5	2025	2025	NUM
gs-4132	178	6	12	12	NUM
gs-4132	178	7	while	while	SCONJ
gs-4132	178	8	5	5	NUM
gs-4132	178	9	integrins	integrin	NOUN
gs-4132	178	10	target	target	VERB
gs-4132	178	11	the	the	DET
gs-4132	178	12	liver	liver	NOUN
gs-4132	178	13	.	.	PUNCT
gs-4132	179	1	this	this	DET
gs-4132	179	2	natural	natural	ADJ
gs-4132	179	3	tropism	tropism	NOUN
gs-4132	179	4	can	can	AUX
gs-4132	179	5	be	be	AUX
gs-4132	179	6	harnessed	harness	VERB
gs-4132	179	7	therapeutically	therapeutically	ADV
gs-4132	179	8	.	.	PUNCT
gs-4132	180	1	liposomes	liposome	NOUN
gs-4132	180	2	require	require	VERB
gs-4132	180	3	active	active	ADJ
gs-4132	180	4	modifications	modification	NOUN
gs-4132	180	5	(	(	PUNCT
gs-4132	180	6	ligand	ligand	NOUN
gs-4132	180	7	conjugation	conjugation	NOUN
gs-4132	180	8	,	,	PUNCT
gs-4132	180	9	antibodies	antibodie	VERB
gs-4132	180	10	,	,	PUNCT
gs-4132	180	11	peptides	peptide	NOUN
gs-4132	180	12	)	)	PUNCT
gs-4132	180	13	to	to	PART
gs-4132	180	14	achieve	achieve	VERB
gs-4132	180	15	similar	similar	ADJ
gs-4132	180	16	specificity	specificity	NOUN
gs-4132	180	17	.	.	PUNCT
gs-4132	181	1	for	for	ADP
gs-4132	181	2	example	example	NOUN
gs-4132	181	3	,	,	PUNCT
gs-4132	181	4	transferrin	transferrin	NOUN
gs-4132	181	5	-	-	PUNCT
gs-4132	181	6	conjugated	conjugate	VERB
gs-4132	181	7	liposomes	liposome	NOUN
gs-4132	181	8	cross	cross	VERB
gs-4132	181	9	the	the	DET
gs-4132	181	10	blood	blood	NOUN
gs-4132	181	11	–	–	PUNCT
gs-4132	181	12	brain	brain	NOUN
gs-4132	181	13	barrier	barrier	NOUN
gs-4132	181	14	and	and	CCONJ
gs-4132	181	15	deliver	deliver	VERB
gs-4132	181	16	drugs	drug	NOUN
gs-4132	181	17	to	to	ADP
gs-4132	181	18	gliomas	glioma	NOUN
gs-4132	181	19	(	(	PUNCT
gs-4132	181	20	ulbrich	ulbrich	X
gs-4132	181	21	et	et	PROPN
gs-4132	181	22	al	al	PROPN
gs-4132	181	23	.	.	PROPN
gs-4132	181	24	,	,	PUNCT
gs-4132	181	25	2009	2009	NUM
gs-4132	181	26	)	)	PUNCT
gs-4132	181	27	.	.	PUNCT
gs-4132	182	1	case	case	NOUN
gs-4132	182	2	example	example	NOUN
gs-4132	182	3	:	:	PUNCT
gs-4132	182	4	exosomes	exosome	NOUN
gs-4132	182	5	engineered	engineer	VERB
gs-4132	182	6	with	with	ADP
gs-4132	182	7	lamp2b	lamp2b	ADJ
gs-4132	182	8	-	-	PUNCT
gs-4132	182	9	rvg	rvg	NOUN
gs-4132	182	10	peptide	peptide	NOUN
gs-4132	182	11	enabled	enable	VERB
gs-4132	182	12	targeted	target	VERB
gs-4132	182	13	delivery	delivery	NOUN
gs-4132	182	14	of	of	ADP
gs-4132	182	15	sirna	sirna	PROPN
gs-4132	182	16	to	to	ADP
gs-4132	182	17	neurons	neuron	NOUN
gs-4132	182	18	(	(	PUNCT
gs-4132	182	19	alvarez	alvarez	PROPN
gs-4132	182	20	-	-	PUNCT
gs-4132	182	21	erviti	erviti	PROPN
gs-4132	182	22	et	et	PROPN
gs-4132	182	23	al	al	PROPN
gs-4132	182	24	.	.	PROPN
gs-4132	182	25	,	,	PUNCT
gs-4132	182	26	2011	2011	NUM
gs-4132	182	27	)	)	PUNCT
gs-4132	182	28	.	.	PUNCT
gs-4132	183	1	liposomes	liposome	NOUN
gs-4132	183	2	decorated	decorate	VERB
gs-4132	183	3	with	with	ADP
gs-4132	183	4	folate	folate	NOUN
gs-4132	183	5	ligands	ligand	NOUN
gs-4132	183	6	selectively	selectively	ADV
gs-4132	183	7	delivered	deliver	VERB
gs-4132	183	8	doxorubicin	doxorubicin	PROPN
gs-4132	183	9	to	to	PART
gs-4132	183	10	folate	folate	VERB
gs-4132	183	11	receptor	receptor	NOUN
gs-4132	183	12	-	-	PUNCT
gs-4132	183	13	positive	positive	ADJ
gs-4132	183	14	ovarian	ovarian	ADJ
gs-4132	183	15	cancer	cancer	NOUN
gs-4132	183	16	cells	cell	NOUN
gs-4132	183	17	(	(	PUNCT
gs-4132	183	18	gabizon	gabizon	PROPN
gs-4132	183	19	et	et	PROPN
gs-4132	183	20	al	al	PROPN
gs-4132	183	21	.	.	PROPN
gs-4132	183	22	,	,	PUNCT
gs-4132	183	23	1999	1999	NUM
gs-4132	183	24	)	)	PUNCT
gs-4132	183	25	.	.	PUNCT
gs-4132	184	1	conclusion	conclusion	NOUN
gs-4132	184	2	:	:	PUNCT
gs-4132	184	3	exosomes	exosome	NOUN
gs-4132	184	4	excel	excel	VERB
gs-4132	184	5	in	in	ADP
gs-4132	184	6	innate	innate	ADJ
gs-4132	184	7	targeting	targeting	NOUN
gs-4132	184	8	,	,	PUNCT
gs-4132	184	9	while	while	SCONJ
gs-4132	184	10	liposomes	liposome	NOUN
gs-4132	184	11	offer	offer	VERB
gs-4132	184	12	customizable	customizable	NOUN
gs-4132	184	13	targeting	target	VERB
gs-4132	184	14	at	at	ADP
gs-4132	184	15	the	the	DET
gs-4132	184	16	expense	expense	NOUN
gs-4132	184	17	of	of	ADP
gs-4132	184	18	additional	additional	ADJ
gs-4132	184	19	design	design	NOUN
gs-4132	184	20	steps	step	NOUN
gs-4132	184	21	.	.	PUNCT
gs-4132	185	1	figure	figure	NOUN
gs-4132	185	2	2	2	NUM
gs-4132	185	3	.	.	PUNCT
gs-4132	186	1	distribution	distribution	NOUN
gs-4132	186	2	of	of	ADP
gs-4132	186	3	therapeutic	therapeutic	ADJ
gs-4132	186	4	applications	application	NOUN
gs-4132	186	5	of	of	ADP
gs-4132	186	6	nanoparticle	nanoparticle	NOUN
gs-4132	186	7	systems	system	NOUN
gs-4132	186	8	.	.	PUNCT
gs-4132	187	1	pie	pie	NOUN
gs-4132	187	2	chart	chart	NOUN
gs-4132	187	3	illustrating	illustrate	VERB
gs-4132	187	4	the	the	DET
gs-4132	187	5	relative	relative	ADJ
gs-4132	187	6	focus	focus	NOUN
gs-4132	187	7	of	of	ADP
gs-4132	187	8	research	research	NOUN
gs-4132	187	9	efforts	effort	NOUN
gs-4132	187	10	into	into	ADP
gs-4132	187	11	therapeutic	therapeutic	ADJ
gs-4132	187	12	applications	application	NOUN
gs-4132	187	13	of	of	ADP
gs-4132	187	14	exosomes	exosome	NOUN
gs-4132	187	15	and	and	CCONJ
gs-4132	187	16	liposomes	liposome	NOUN
gs-4132	187	17	across	across	ADP
gs-4132	187	18	major	major	ADJ
gs-4132	187	19	disease	disease	NOUN
gs-4132	187	20	areas	area	NOUN
gs-4132	187	21	.	.	PUNCT
gs-4132	188	1	cancer	cancer	NOUN
gs-4132	188	2	accounts	account	VERB
gs-4132	188	3	for	for	ADP
gs-4132	188	4	the	the	DET
gs-4132	188	5	largest	large	ADJ
gs-4132	188	6	share	share	NOUN
gs-4132	188	7	(	(	PUNCT
gs-4132	188	8	40	40	NUM
gs-4132	188	9	%	%	NOUN
gs-4132	188	10	)	)	PUNCT
gs-4132	188	11	,	,	PUNCT
gs-4132	188	12	followed	follow	VERB
gs-4132	188	13	by	by	ADP
gs-4132	188	14	neurological	neurological	ADJ
gs-4132	188	15	disorders	disorder	NOUN
gs-4132	188	16	(	(	PUNCT
gs-4132	188	17	20	20	NUM
gs-4132	188	18	%	%	NOUN
gs-4132	188	19	)	)	PUNCT
gs-4132	188	20	,	,	PUNCT
gs-4132	188	21	regenerative	regenerative	ADJ
gs-4132	188	22	medicine	medicine	NOUN
gs-4132	188	23	(	(	PUNCT
gs-4132	188	24	15	15	NUM
gs-4132	188	25	%	%	NOUN
gs-4132	188	26	)	)	PUNCT
gs-4132	188	27	,	,	PUNCT
gs-4132	188	28	cardiovascular	cardiovascular	ADJ
gs-4132	188	29	disease	disease	NOUN
gs-4132	188	30	(	(	PUNCT
gs-4132	188	31	15	15	NUM
gs-4132	188	32	%	%	NOUN
gs-4132	188	33	)	)	PUNCT
gs-4132	188	34	,	,	PUNCT
gs-4132	188	35	and	and	CCONJ
gs-4132	188	36	infectious	infectious	ADJ
gs-4132	188	37	diseases	disease	NOUN
gs-4132	188	38	(	(	PUNCT
gs-4132	188	39	10	10	NUM
gs-4132	188	40	%	%	NOUN
gs-4132	188	41	)	)	PUNCT
gs-4132	188	42	.	.	PUNCT
gs-4132	189	1	the	the	DET
gs-4132	189	2	figure	figure	NOUN
gs-4132	189	3	highlights	highlight	VERB
gs-4132	189	4	the	the	DET
gs-4132	189	5	dominance	dominance	NOUN
gs-4132	189	6	of	of	ADP
gs-4132	189	7	cancer	cancer	NOUN
gs-4132	189	8	-	-	PUNCT
gs-4132	189	9	focused	focus	VERB
gs-4132	189	10	research	research	NOUN
gs-4132	189	11	in	in	ADP
gs-4132	189	12	nanomedicine	nanomedicine	NOUN
gs-4132	189	13	but	but	CCONJ
gs-4132	189	14	underscores	underscore	VERB
gs-4132	189	15	the	the	DET
gs-4132	189	16	growing	grow	VERB
gs-4132	189	17	interest	interest	NOUN
gs-4132	189	18	in	in	ADP
gs-4132	189	19	regenerative	regenerative	ADJ
gs-4132	189	20	and	and	CCONJ
gs-4132	189	21	neurological	neurological	ADJ
gs-4132	189	22	applications	application	NOUN
gs-4132	189	23	.	.	PUNCT
gs-4132	190	1	georgian	georgian	NOUN
gs-4132	190	2	scientists/	scientists/	NUM
gs-4132	190	3	.	.	PUNCT
gs-4132	191	1	7	7	NUM
gs-4132	191	2	n	n	DET
gs-4132	191	3	4	4	NUM
gs-4132	191	4	,	,	PUNCT
gs-4132	191	5	2025	2025	NUM
gs-4132	191	6	13	13	NUM
gs-4132	191	7	7.3	7.3	NUM
gs-4132	191	8	cargo	cargo	NOUN
gs-4132	191	9	loading	loading	NOUN
gs-4132	191	10	and	and	CCONJ
gs-4132	191	11	release	release	VERB
gs-4132	191	12	exosome	exosome	NOUN
gs-4132	191	13	cargo	cargo	NOUN
gs-4132	191	14	is	be	AUX
gs-4132	191	15	defined	define	VERB
gs-4132	191	16	by	by	ADP
gs-4132	191	17	the	the	DET
gs-4132	191	18	parental	parental	ADJ
gs-4132	191	19	cell	cell	NOUN
gs-4132	191	20	and	and	CCONJ
gs-4132	191	21	microenvironment	microenvironment	NOUN
gs-4132	191	22	,	,	PUNCT
gs-4132	191	23	though	though	SCONJ
gs-4132	191	24	methods	method	NOUN
gs-4132	191	25	such	such	ADJ
gs-4132	191	26	as	as	ADP
gs-4132	191	27	electroporation	electroporation	NOUN
gs-4132	191	28	,	,	PUNCT
gs-4132	191	29	transfection	transfection	NOUN
gs-4132	191	30	,	,	PUNCT
gs-4132	191	31	or	or	CCONJ
gs-4132	191	32	chemical	chemical	NOUN
gs-4132	191	33	conjugation	conjugation	NOUN
gs-4132	191	34	can	can	AUX
gs-4132	191	35	enhance	enhance	VERB
gs-4132	191	36	drug	drug	NOUN
gs-4132	191	37	loading	loading	NOUN
gs-4132	191	38	(	(	PUNCT
gs-4132	191	39	vader	vader	NOUN
gs-4132	191	40	et	et	PROPN
gs-4132	191	41	al	al	PROPN
gs-4132	191	42	.	.	PROPN
gs-4132	191	43	,	,	PUNCT
gs-4132	191	44	2016	2016	NUM
gs-4132	191	45	)	)	PUNCT
gs-4132	191	46	.	.	PUNCT
gs-4132	192	1	however	however	ADV
gs-4132	192	2	,	,	PUNCT
gs-4132	192	3	loading	loading	NOUN
gs-4132	192	4	efficiency	efficiency	NOUN
gs-4132	192	5	and	and	CCONJ
gs-4132	192	6	reproducibility	reproducibility	NOUN
gs-4132	192	7	remain	remain	VERB
gs-4132	192	8	challenges	challenge	NOUN
gs-4132	192	9	.	.	PUNCT
gs-4132	193	1	liposomes	liposome	NOUN
gs-4132	193	2	,	,	PUNCT
gs-4132	193	3	by	by	ADP
gs-4132	193	4	contrast	contrast	NOUN
gs-4132	193	5	,	,	PUNCT
gs-4132	193	6	allow	allow	VERB
gs-4132	193	7	predictable	predictable	ADJ
gs-4132	193	8	high	high	ADJ
gs-4132	193	9	-	-	PUNCT
gs-4132	193	10	efficiency	efficiency	NOUN
gs-4132	193	11	encapsulation	encapsulation	NOUN
gs-4132	193	12	of	of	ADP
gs-4132	193	13	hydrophilic	hydrophilic	ADJ
gs-4132	193	14	and	and	CCONJ
gs-4132	193	15	hydrophobic	hydrophobic	NOUN
gs-4132	193	16	drugs	drug	NOUN
gs-4132	193	17	.	.	PUNCT
gs-4132	194	1	techniques	technique	NOUN
gs-4132	194	2	such	such	ADJ
gs-4132	194	3	as	as	ADP
gs-4132	194	4	thin	thin	ADJ
gs-4132	194	5	-	-	PUNCT
gs-4132	194	6	film	film	NOUN
gs-4132	194	7	hydration	hydration	NOUN
gs-4132	194	8	and	and	CCONJ
gs-4132	194	9	ethanol	ethanol	NOUN
gs-4132	194	10	injection	injection	NOUN
gs-4132	194	11	are	be	AUX
gs-4132	194	12	scalable	scalable	ADJ
gs-4132	194	13	and	and	CCONJ
gs-4132	194	14	reproducible	reproducible	ADJ
gs-4132	194	15	(	(	PUNCT
gs-4132	194	16	allen	allen	NOUN
gs-4132	194	17	and	and	CCONJ
gs-4132	194	18	cullis	cullis	PROPN
gs-4132	194	19	,	,	PUNCT
gs-4132	194	20	2013	2013	NUM
gs-4132	194	21	)	)	PUNCT
gs-4132	194	22	.	.	PUNCT
gs-4132	195	1	controlled	control	VERB
gs-4132	195	2	release	release	NOUN
gs-4132	195	3	systems	system	NOUN
gs-4132	195	4	(	(	PUNCT
gs-4132	195	5	ph	ph	ADJ
gs-4132	195	6	-	-	ADJ
gs-4132	195	7	sensitive	sensitive	ADJ
gs-4132	195	8	liposomes	liposome	NOUN
gs-4132	195	9	)	)	PUNCT
gs-4132	195	10	further	far	ADV
gs-4132	195	11	enhance	enhance	VERB
gs-4132	195	12	delivery	delivery	NOUN
gs-4132	195	13	to	to	ADP
gs-4132	195	14	tumors	tumor	NOUN
gs-4132	195	15	.	.	PUNCT
gs-4132	196	1	case	case	NOUN
gs-4132	196	2	example	example	NOUN
gs-4132	196	3	:	:	PUNCT
gs-4132	196	4	exosomes	exosome	NOUN
gs-4132	196	5	loaded	load	VERB
gs-4132	196	6	with	with	ADP
gs-4132	196	7	doxorubicin	doxorubicin	PROPN
gs-4132	196	8	showed	show	VERB
gs-4132	196	9	superior	superior	ADJ
gs-4132	196	10	uptake	uptake	NOUN
gs-4132	196	11	by	by	ADP
gs-4132	196	12	drug	drug	NOUN
gs-4132	196	13	-	-	PUNCT
gs-4132	196	14	resistant	resistant	ADJ
gs-4132	196	15	breast	breast	NOUN
gs-4132	196	16	cancer	cancer	NOUN
gs-4132	196	17	cells	cell	NOUN
gs-4132	196	18	compared	compare	VERB
gs-4132	196	19	to	to	ADP
gs-4132	196	20	free	free	ADJ
gs-4132	196	21	drug	drug	NOUN
gs-4132	196	22	(	(	PUNCT
gs-4132	196	23	tian	tian	PROPN
gs-4132	196	24	et	et	PROPN
gs-4132	196	25	al	al	PROPN
gs-4132	196	26	.	.	PROPN
gs-4132	196	27	,	,	PUNCT
gs-4132	196	28	2014	2014	NUM
gs-4132	196	29	)	)	PUNCT
gs-4132	196	30	.	.	PUNCT
gs-4132	197	1	liposomal	liposomal	ADJ
gs-4132	197	2	irinotecan	irinotecan	NOUN
gs-4132	197	3	(	(	PUNCT
gs-4132	197	4	onivyde	onivyde	PROPN
gs-4132	197	5	®	®	NOUN
gs-4132	197	6	)	)	PUNCT
gs-4132	197	7	improved	improve	VERB
gs-4132	197	8	survival	survival	NOUN
gs-4132	197	9	in	in	ADP
gs-4132	197	10	pancreatic	pancreatic	ADJ
gs-4132	197	11	cancer	cancer	NOUN
gs-4132	197	12	by	by	ADP
gs-4132	197	13	stabilizing	stabilize	VERB
gs-4132	197	14	drug	drug	NOUN
gs-4132	197	15	release	release	NOUN
gs-4132	197	16	and	and	CCONJ
gs-4132	197	17	accumulation	accumulation	NOUN
gs-4132	197	18	(	(	PUNCT
gs-4132	197	19	wang	wang	PROPN
gs-4132	197	20	-	-	PUNCT
gs-4132	197	21	gillam	gillam	PROPN
gs-4132	197	22	et	et	PROPN
gs-4132	197	23	al	al	PROPN
gs-4132	197	24	.	.	PROPN
gs-4132	197	25	,	,	PUNCT
gs-4132	197	26	2016	2016	NUM
gs-4132	197	27	)	)	PUNCT
gs-4132	197	28	.	.	PUNCT
gs-4132	198	1	conclusion	conclusion	NOUN
gs-4132	198	2	:	:	PUNCT
gs-4132	198	3	liposomes	liposome	NOUN
gs-4132	198	4	outperform	outperform	VERB
gs-4132	198	5	in	in	ADP
gs-4132	198	6	controlled	control	VERB
gs-4132	198	7	drug	drug	NOUN
gs-4132	198	8	loading	loading	NOUN
gs-4132	198	9	,	,	PUNCT
gs-4132	198	10	while	while	SCONJ
gs-4132	198	11	exosomes	exosome	NOUN
gs-4132	198	12	provide	provide	VERB
gs-4132	198	13	biologically	biologically	ADV
gs-4132	198	14	relevant	relevant	ADJ
gs-4132	198	15	,	,	PUNCT
gs-4132	198	16	though	though	SCONJ
gs-4132	198	17	less	less	ADV
gs-4132	198	18	standardized	standardized	ADJ
gs-4132	198	19	,	,	PUNCT
gs-4132	198	20	cargo	cargo	NOUN
gs-4132	198	21	delivery	delivery	NOUN
gs-4132	198	22	.	.	PUNCT
gs-4132	199	1	7.4	7.4	NUM
gs-4132	199	2	pharmacokinetics	pharmacokinetic	NOUN
gs-4132	199	3	and	and	CCONJ
gs-4132	199	4	half	half	ADJ
gs-4132	199	5	-	-	PUNCT
gs-4132	199	6	life	life	NOUN
gs-4132	199	7	exosomes	exosome	NOUN
gs-4132	199	8	exhibit	exhibit	VERB
gs-4132	199	9	extended	extend	VERB
gs-4132	199	10	circulation	circulation	NOUN
gs-4132	199	11	times	time	NOUN
gs-4132	199	12	due	due	ADJ
gs-4132	199	13	to	to	ADP
gs-4132	199	14	cd47	cd47	PROPN
gs-4132	199	15	-	-	PUNCT
gs-4132	199	16	mediated	mediate	VERB
gs-4132	199	17	evasion	evasion	NOUN
gs-4132	199	18	of	of	ADP
gs-4132	199	19	mononuclear	mononuclear	ADJ
gs-4132	199	20	phagocytes	phagocyte	NOUN
gs-4132	199	21	(	(	PUNCT
gs-4132	199	22	morrissey	morrissey	PROPN
gs-4132	199	23	et	et	PROPN
gs-4132	199	24	al	al	PROPN
gs-4132	199	25	.	.	PROPN
gs-4132	199	26	,	,	PUNCT
gs-4132	199	27	2020	2020	NUM
gs-4132	199	28	)	)	PUNCT
gs-4132	199	29	.	.	PUNCT
gs-4132	200	1	yet	yet	ADV
gs-4132	200	2	,	,	PUNCT
gs-4132	200	3	biodistribution	biodistribution	NOUN
gs-4132	200	4	studies	study	NOUN
gs-4132	200	5	show	show	VERB
gs-4132	200	6	rapid	rapid	ADJ
gs-4132	200	7	accumulation	accumulation	NOUN
gs-4132	200	8	in	in	ADP
gs-4132	200	9	the	the	DET
gs-4132	200	10	liver	liver	NOUN
gs-4132	200	11	,	,	PUNCT
gs-4132	200	12	spleen	spleen	NOUN
gs-4132	200	13	,	,	PUNCT
gs-4132	200	14	and	and	CCONJ
gs-4132	200	15	lungs	lung	NOUN
gs-4132	200	16	(	(	PUNCT
gs-4132	200	17	wiklander	wiklander	X
gs-4132	200	18	et	et	PROPN
gs-4132	200	19	al	al	PROPN
gs-4132	200	20	.	.	PROPN
gs-4132	200	21	,	,	PUNCT
gs-4132	200	22	2015	2015	NUM
gs-4132	200	23	)	)	PUNCT
gs-4132	200	24	.	.	PUNCT
gs-4132	201	1	liposomes	liposome	NOUN
gs-4132	201	2	display	display	VERB
gs-4132	201	3	pharmacokinetics	pharmacokinetic	NOUN
gs-4132	201	4	highly	highly	ADV
gs-4132	201	5	dependent	dependent	ADJ
gs-4132	201	6	on	on	ADP
gs-4132	201	7	pegylation	pegylation	NOUN
gs-4132	201	8	and	and	CCONJ
gs-4132	201	9	size	size	NOUN
gs-4132	201	10	.	.	PUNCT
gs-4132	202	1	pegylated	pegylate	VERB
gs-4132	202	2	liposomes	liposome	NOUN
gs-4132	202	3	remain	remain	VERB
gs-4132	202	4	in	in	ADP
gs-4132	202	5	circulation	circulation	NOUN
gs-4132	202	6	for	for	ADP
gs-4132	202	7	hours	hour	NOUN
gs-4132	202	8	to	to	ADP
gs-4132	202	9	days	day	NOUN
gs-4132	202	10	,	,	PUNCT
gs-4132	202	11	but	but	CCONJ
gs-4132	202	12	uptake	uptake	ADJ
gs-4132	202	13	by	by	ADP
gs-4132	202	14	the	the	DET
gs-4132	202	15	reticuloendothelial	reticuloendothelial	ADJ
gs-4132	202	16	system	system	NOUN
gs-4132	202	17	(	(	PUNCT
gs-4132	202	18	res	re	NOUN
gs-4132	202	19	)	)	PUNCT
gs-4132	202	20	remains	remain	VERB
gs-4132	202	21	significant	significant	ADJ
gs-4132	202	22	(	(	PUNCT
gs-4132	202	23	barenholz	barenholz	NOUN
gs-4132	202	24	,	,	PUNCT
gs-4132	202	25	2012	2012	NUM
gs-4132	202	26	)	)	PUNCT
gs-4132	202	27	.	.	PUNCT
gs-4132	203	1	conclusion	conclusion	NOUN
gs-4132	203	2	:	:	PUNCT
gs-4132	203	3	both	both	DET
gs-4132	203	4	systems	system	NOUN
gs-4132	203	5	face	face	VERB
gs-4132	203	6	res	re	NOUN
gs-4132	203	7	clearance	clearance	NOUN
gs-4132	203	8	challenges	challenge	NOUN
gs-4132	203	9	,	,	PUNCT
gs-4132	203	10	but	but	CCONJ
gs-4132	203	11	exosomes	exosome	NOUN
gs-4132	203	12	may	may	AUX
gs-4132	203	13	achieve	achieve	VERB
gs-4132	203	14	longer	long	ADJ
gs-4132	203	15	retention	retention	NOUN
gs-4132	203	16	in	in	ADP
gs-4132	203	17	certain	certain	ADJ
gs-4132	203	18	contexts	context	NOUN
gs-4132	203	19	.	.	PUNCT
gs-4132	204	1	7.5	7.5	NUM
gs-4132	204	2	manufacturing	manufacturing	NOUN
gs-4132	204	3	and	and	CCONJ
gs-4132	204	4	scalability	scalability	NOUN
gs-4132	204	5	exosome	exosome	PROPN
gs-4132	204	6	production	production	NOUN
gs-4132	204	7	is	be	AUX
gs-4132	204	8	constrained	constrain	VERB
gs-4132	204	9	by	by	ADP
gs-4132	204	10	:	:	PUNCT
gs-4132	204	11	heterogeneity	heterogeneity	NOUN
gs-4132	204	12	of	of	ADP
gs-4132	204	13	vesicles	vesicle	NOUN
gs-4132	204	14	.	.	PUNCT
gs-4132	205	1	technical	technical	ADJ
gs-4132	205	2	challenges	challenge	NOUN
gs-4132	205	3	in	in	ADP
gs-4132	205	4	isolation	isolation	NOUN
gs-4132	205	5	(	(	PUNCT
gs-4132	205	6	ultracentrifugation	ultracentrifugation	NOUN
gs-4132	205	7	,	,	PUNCT
gs-4132	205	8	size	size	NOUN
gs-4132	205	9	-	-	PUNCT
gs-4132	205	10	exclusion	exclusion	NOUN
gs-4132	205	11	chromatography	chromatography	NOUN
gs-4132	205	12	,	,	PUNCT
gs-4132	205	13	tangential	tangential	ADJ
gs-4132	205	14	flow	flow	NOUN
gs-4132	205	15	filtration	filtration	NOUN
gs-4132	205	16	)	)	PUNCT
gs-4132	205	17	.	.	PUNCT
gs-4132	206	1	limited	limited	ADJ
gs-4132	206	2	yields	yield	NOUN
gs-4132	206	3	from	from	ADP
gs-4132	206	4	cell	cell	NOUN
gs-4132	206	5	cultures	culture	NOUN
gs-4132	206	6	(	(	PUNCT
gs-4132	206	7	lötvall	lötvall	INTJ
gs-4132	206	8	et	et	PROPN
gs-4132	206	9	al	al	PROPN
gs-4132	206	10	.	.	PROPN
gs-4132	206	11	,	,	PUNCT
gs-4132	206	12	2014	2014	NUM
gs-4132	206	13	)	)	PUNCT
gs-4132	206	14	.	.	PUNCT
gs-4132	207	1	liposomes	liposome	NOUN
gs-4132	207	2	benefit	benefit	VERB
gs-4132	207	3	from	from	ADP
gs-4132	207	4	decades	decade	NOUN
gs-4132	207	5	of	of	ADP
gs-4132	207	6	optimization	optimization	NOUN
gs-4132	207	7	,	,	PUNCT
gs-4132	207	8	with	with	ADP
gs-4132	207	9	gmp	gmp	NOUN
gs-4132	207	10	-	-	PUNCT
gs-4132	207	11	scale	scale	NOUN
gs-4132	207	12	production	production	NOUN
gs-4132	207	13	and	and	CCONJ
gs-4132	207	14	regulatory	regulatory	ADJ
gs-4132	207	15	approval	approval	NOUN
gs-4132	207	16	pathways	pathway	NOUN
gs-4132	207	17	well	well	ADV
gs-4132	207	18	established	establish	VERB
gs-4132	207	19	(	(	PUNCT
gs-4132	207	20	allen	allen	NOUN
gs-4132	207	21	and	and	CCONJ
gs-4132	207	22	cullis	cullis	PROPN
gs-4132	207	23	,	,	PUNCT
gs-4132	207	24	2013	2013	NUM
gs-4132	207	25	)	)	PUNCT
gs-4132	207	26	.	.	PUNCT
gs-4132	208	1	case	case	NOUN
gs-4132	208	2	example	example	NOUN
gs-4132	208	3	:	:	PUNCT
gs-4132	208	4	exosome	exosome	PROPN
gs-4132	208	5	therapies	therapy	NOUN
gs-4132	208	6	remain	remain	VERB
gs-4132	208	7	largely	largely	ADV
gs-4132	208	8	preclinical	preclinical	ADJ
gs-4132	208	9	or	or	CCONJ
gs-4132	208	10	in	in	ADP
gs-4132	208	11	early	early	ADJ
gs-4132	208	12	trials	trial	NOUN
gs-4132	208	13	.	.	PUNCT
gs-4132	209	1	georgian	georgian	NOUN
gs-4132	209	2	scientists/	scientists/	NUM
gs-4132	209	3	.	.	PUNCT
gs-4132	210	1	7	7	NUM
gs-4132	210	2	n	n	DET
gs-4132	210	3	4	4	NUM
gs-4132	210	4	,	,	PUNCT
gs-4132	210	5	2025	2025	NUM
gs-4132	210	6	14	14	NUM
gs-4132	210	7	liposomal	liposomal	ADJ
gs-4132	210	8	drugs	drug	NOUN
gs-4132	210	9	are	be	AUX
gs-4132	210	10	globally	globally	ADV
gs-4132	210	11	marketed	market	VERB
gs-4132	210	12	,	,	PUNCT
gs-4132	210	13	demonstrating	demonstrate	VERB
gs-4132	210	14	scalability	scalability	NOUN
gs-4132	210	15	.	.	PUNCT
gs-4132	211	1	conclusion	conclusion	NOUN
gs-4132	211	2	:	:	PUNCT
gs-4132	211	3	liposomes	liposome	NOUN
gs-4132	211	4	are	be	AUX
gs-4132	211	5	currently	currently	ADV
gs-4132	211	6	superior	superior	ADJ
gs-4132	211	7	in	in	ADP
gs-4132	211	8	industrial	industrial	ADJ
gs-4132	211	9	feasibility	feasibility	NOUN
gs-4132	211	10	,	,	PUNCT
gs-4132	211	11	though	though	SCONJ
gs-4132	211	12	ev	ev	NOUN
gs-4132	211	13	-	-	PUNCT
gs-4132	211	14	mimetics	mimetic	NOUN
gs-4132	211	15	may	may	AUX
gs-4132	211	16	close	close	VERB
gs-4132	211	17	this	this	DET
gs-4132	211	18	gap	gap	NOUN
gs-4132	211	19	.	.	PUNCT
gs-4132	212	1	7.6	7.6	NUM
gs-4132	212	2	safety	safety	NOUN
gs-4132	212	3	and	and	CCONJ
gs-4132	212	4	regulatory	regulatory	ADJ
gs-4132	212	5	considerations	consideration	NOUN
gs-4132	212	6	regulatory	regulatory	ADJ
gs-4132	212	7	authorities	authority	NOUN
gs-4132	212	8	(	(	PUNCT
gs-4132	212	9	fda	fda	PROPN
gs-4132	212	10	,	,	PUNCT
gs-4132	212	11	ema	ema	PROPN
gs-4132	212	12	)	)	PUNCT
gs-4132	212	13	have	have	AUX
gs-4132	212	14	approved	approve	VERB
gs-4132	212	15	multiple	multiple	ADJ
gs-4132	212	16	liposome	liposome	NOUN
gs-4132	212	17	formulations	formulation	NOUN
gs-4132	212	18	.	.	PUNCT
gs-4132	213	1	guidelines	guideline	NOUN
gs-4132	213	2	for	for	ADP
gs-4132	213	3	exosome	exosome	ADJ
gs-4132	213	4	therapeutics	therapeutic	NOUN
gs-4132	213	5	are	be	AUX
gs-4132	213	6	still	still	ADV
gs-4132	213	7	emerging	emerge	VERB
gs-4132	213	8	,	,	PUNCT
gs-4132	213	9	with	with	ADP
gs-4132	213	10	emphasis	emphasis	NOUN
gs-4132	213	11	on	on	ADP
gs-4132	213	12	source	source	NOUN
gs-4132	213	13	standardization	standardization	NOUN
gs-4132	213	14	,	,	PUNCT
gs-4132	213	15	purification	purification	NOUN
gs-4132	213	16	,	,	PUNCT
gs-4132	213	17	and	and	CCONJ
gs-4132	213	18	safety	safety	NOUN
gs-4132	213	19	testing	testing	NOUN
gs-4132	213	20	(	(	PUNCT
gs-4132	213	21	reiner	reiner	NOUN
gs-4132	213	22	et	et	PROPN
gs-4132	213	23	al	al	PROPN
gs-4132	213	24	.	.	PROPN
gs-4132	213	25	,	,	PUNCT
gs-4132	213	26	2017	2017	NUM
gs-4132	213	27	)	)	PUNCT
gs-4132	213	28	.	.	PUNCT
gs-4132	214	1	concerns	concern	NOUN
gs-4132	214	2	include	include	VERB
gs-4132	214	3	:	:	PUNCT
gs-4132	214	4	potential	potential	ADJ
gs-4132	214	5	for	for	ADP
gs-4132	214	6	horizontal	horizontal	ADJ
gs-4132	214	7	gene	gene	NOUN
gs-4132	214	8	transfer	transfer	NOUN
gs-4132	214	9	via	via	ADP
gs-4132	214	10	exosomal	exosomal	ADJ
gs-4132	214	11	dna	dna	PROPN
gs-4132	214	12	/	/	SYM
gs-4132	214	13	rna	rna	PROPN
gs-4132	214	14	.	.	PUNCT
gs-4132	215	1	risk	risk	NOUN
gs-4132	215	2	of	of	ADP
gs-4132	215	3	tumor	tumor	NOUN
gs-4132	215	4	-	-	PUNCT
gs-4132	215	5	promoting	promote	VERB
gs-4132	215	6	cargo	cargo	NOUN
gs-4132	215	7	in	in	ADP
gs-4132	215	8	certain	certain	ADJ
gs-4132	215	9	exosome	exosome	NOUN
gs-4132	215	10	populations	population	NOUN
gs-4132	215	11	.	.	PUNCT
gs-4132	216	1	conclusion	conclusion	NOUN
gs-4132	216	2	:	:	PUNCT
gs-4132	216	3	liposomes	liposome	NOUN
gs-4132	216	4	have	have	VERB
gs-4132	216	5	a	a	DET
gs-4132	216	6	regulatory	regulatory	ADJ
gs-4132	216	7	head	head	NOUN
gs-4132	216	8	start	start	VERB
gs-4132	216	9	,	,	PUNCT
gs-4132	216	10	but	but	CCONJ
gs-4132	216	11	exosomes	exosome	NOUN
gs-4132	216	12	face	face	VERB
gs-4132	216	13	greater	great	ADJ
gs-4132	216	14	hurdles	hurdle	NOUN
gs-4132	216	15	due	due	ADP
gs-4132	216	16	to	to	ADP
gs-4132	216	17	biological	biological	ADJ
gs-4132	216	18	complexity	complexity	NOUN
gs-4132	216	19	.	.	PUNCT
gs-4132	217	1	7.7	7.7	NUM
gs-4132	217	2	cost	cost	NOUN
gs-4132	217	3	and	and	CCONJ
gs-4132	217	4	clinical	clinical	ADJ
gs-4132	217	5	feasibility	feasibility	NOUN
gs-4132	217	6	exosome	exosome	NOUN
gs-4132	217	7	-	-	PUNCT
gs-4132	217	8	based	base	VERB
gs-4132	217	9	therapies	therapy	NOUN
gs-4132	217	10	require	require	VERB
gs-4132	217	11	cell	cell	NOUN
gs-4132	217	12	culture	culture	NOUN
gs-4132	217	13	facilities	facility	NOUN
gs-4132	217	14	,	,	PUNCT
gs-4132	217	15	strict	strict	ADJ
gs-4132	217	16	donor	donor	NOUN
gs-4132	217	17	screening	screening	NOUN
gs-4132	217	18	,	,	PUNCT
gs-4132	217	19	and	and	CCONJ
gs-4132	217	20	advanced	advanced	ADJ
gs-4132	217	21	purification	purification	NOUN
gs-4132	217	22	technologies	technology	NOUN
gs-4132	217	23	.	.	PUNCT
gs-4132	218	1	costs	cost	NOUN
gs-4132	218	2	remain	remain	VERB
gs-4132	218	3	high	high	ADJ
gs-4132	218	4	(	(	PUNCT
gs-4132	218	5	lener	lener	NOUN
gs-4132	218	6	et	et	PROPN
gs-4132	218	7	al	al	PROPN
gs-4132	218	8	.	.	PROPN
gs-4132	218	9	,	,	PUNCT
gs-4132	218	10	2015	2015	NUM
gs-4132	218	11	)	)	PUNCT
gs-4132	218	12	.	.	PUNCT
gs-4132	219	1	liposome	liposome	NOUN
gs-4132	219	2	production	production	NOUN
gs-4132	219	3	is	be	AUX
gs-4132	219	4	relatively	relatively	ADV
gs-4132	219	5	inexpensive	inexpensive	ADJ
gs-4132	219	6	and	and	CCONJ
gs-4132	219	7	already	already	ADV
gs-4132	219	8	integrated	integrate	VERB
gs-4132	219	9	into	into	ADP
gs-4132	219	10	pharmaceutical	pharmaceutical	ADJ
gs-4132	219	11	pipelines	pipeline	NOUN
gs-4132	219	12	.	.	PUNCT
gs-4132	220	1	7.8	7.8	NUM
gs-4132	220	2	overall	overall	ADJ
gs-4132	220	3	comparative	comparative	ADJ
gs-4132	220	4	summary	summary	NOUN
gs-4132	220	5	feature	feature	NOUN
gs-4132	220	6	exosomes	exosome	NOUN
gs-4132	220	7	liposomes	liposome	VERB
gs-4132	220	8	other	other	ADJ
gs-4132	220	9	nanoparticles	nanoparticle	NOUN
gs-4132	220	10	biocompatibility	biocompatibility	NOUN
gs-4132	220	11	high	high	ADJ
gs-4132	220	12	(	(	PUNCT
gs-4132	220	13	autologous	autologous	ADJ
gs-4132	220	14	)	)	PUNCT
gs-4132	220	15	moderate	moderate	ADJ
gs-4132	220	16	–	–	PUNCT
gs-4132	220	17	high	high	ADJ
gs-4132	220	18	(	(	PUNCT
gs-4132	220	19	pegylation	pegylation	NOUN
gs-4132	220	20	helps	help	VERB
gs-4132	220	21	)	)	PUNCT
gs-4132	220	22	variable	variable	ADJ
gs-4132	220	23	immunogenicity	immunogenicity	NOUN
gs-4132	220	24	low	low	ADJ
gs-4132	220	25	(	(	PUNCT
gs-4132	220	26	unless	unless	SCONJ
gs-4132	220	27	allogeneic	allogeneic	ADJ
gs-4132	220	28	)	)	PUNCT
gs-4132	220	29	possible	possible	ADJ
gs-4132	220	30	carpa	carpa	NOUN
gs-4132	220	31	polymer	polymer	NOUN
gs-4132	220	32	/	/	SYM
gs-4132	220	33	inorganic	inorganic	NOUN
gs-4132	220	34	toxicity	toxicity	NOUN
gs-4132	220	35	possible	possible	ADJ
gs-4132	220	36	targeting	target	VERB
gs-4132	220	37	natural	natural	ADJ
gs-4132	220	38	tropism	tropism	NOUN
gs-4132	220	39	requires	require	VERB
gs-4132	220	40	modification	modification	NOUN
gs-4132	220	41	modifiable	modifiable	ADJ
gs-4132	220	42	cargo	cargo	NOUN
gs-4132	220	43	loading	loading	NOUN
gs-4132	220	44	variable	variable	NOUN
gs-4132	220	45	,	,	PUNCT
gs-4132	220	46	less	less	ADV
gs-4132	220	47	predictable	predictable	ADJ
gs-4132	220	48	high	high	ADJ
gs-4132	220	49	,	,	PUNCT
gs-4132	220	50	reproducible	reproducible	VERB
gs-4132	220	51	high	high	ADJ
gs-4132	220	52	pharmacokinetics	pharmacokinetic	NOUN
gs-4132	220	53	long	long	ADV
gs-4132	220	54	,	,	PUNCT
gs-4132	220	55	res	re	NOUN
gs-4132	220	56	clearance	clearance	NOUN
gs-4132	220	57	long	long	ADV
gs-4132	220	58	(	(	PUNCT
gs-4132	220	59	pegylated	pegylated	ADJ
gs-4132	220	60	)	)	PUNCT
gs-4132	220	61	variable	variable	ADJ
gs-4132	220	62	scalability	scalability	NOUN
gs-4132	220	63	low	low	ADJ
gs-4132	220	64	–	–	PUNCT
gs-4132	220	65	medium	medium	ADJ
gs-4132	220	66	high	high	ADJ
gs-4132	220	67	high	high	ADJ
gs-4132	220	68	regulatory	regulatory	ADJ
gs-4132	220	69	approval	approval	NOUN
gs-4132	220	70	emerging	emerge	VERB
gs-4132	220	71	multiple	multiple	ADJ
gs-4132	220	72	fda	fda	PROPN
gs-4132	220	73	approvals	approval	NOUN
gs-4132	220	74	few	few	ADJ
gs-4132	220	75	(	(	PUNCT
gs-4132	220	76	in	in	ADP
gs-4132	220	77	development	development	NOUN
gs-4132	220	78	)	)	PUNCT
gs-4132	220	79	georgian	georgian	NOUN
gs-4132	220	80	scientists/	scientists/	NUM
gs-4132	220	81	.	.	PUNCT
gs-4132	221	1	7	7	NUM
gs-4132	221	2	n	n	DET
gs-4132	221	3	4	4	NUM
gs-4132	221	4	,	,	PUNCT
gs-4132	221	5	2025	2025	NUM
gs-4132	221	6	15	15	NUM
gs-4132	221	7	8	8	NUM
gs-4132	221	8	.	.	PUNCT
gs-4132	222	1	challenges	challenge	NOUN
gs-4132	222	2	and	and	CCONJ
gs-4132	222	3	future	future	ADJ
gs-4132	222	4	perspectives	perspective	NOUN
gs-4132	222	5	8.1	8.1	NUM
gs-4132	222	6	challenges	challenge	NOUN
gs-4132	222	7	in	in	ADP
gs-4132	222	8	exosome	exosome	NOUN
gs-4132	222	9	-	-	PUNCT
gs-4132	222	10	based	base	VERB
gs-4132	222	11	therapeutics	therapeutic	NOUN
gs-4132	222	12	8.1.1	8.1.1	NUM
gs-4132	222	13	isolation	isolation	NOUN
gs-4132	222	14	and	and	CCONJ
gs-4132	222	15	purification	purification	NOUN
gs-4132	222	16	one	one	NUM
gs-4132	222	17	of	of	ADP
gs-4132	222	18	the	the	DET
gs-4132	222	19	primary	primary	ADJ
gs-4132	222	20	barriers	barrier	NOUN
gs-4132	222	21	to	to	ADP
gs-4132	222	22	clinical	clinical	ADJ
gs-4132	222	23	translation	translation	NOUN
gs-4132	222	24	of	of	ADP
gs-4132	222	25	exosome	exosome	PROPN
gs-4132	222	26	therapeutics	therapeutic	NOUN
gs-4132	222	27	is	be	AUX
gs-4132	222	28	the	the	DET
gs-4132	222	29	difficulty	difficulty	NOUN
gs-4132	222	30	of	of	ADP
gs-4132	222	31	isolation	isolation	NOUN
gs-4132	222	32	.	.	PUNCT
gs-4132	223	1	current	current	ADJ
gs-4132	223	2	methods	method	NOUN
gs-4132	223	3	include	include	VERB
gs-4132	223	4	:	:	PUNCT
gs-4132	223	5	differential	differential	ADJ
gs-4132	223	6	ultracentrifugation	ultracentrifugation	NOUN
gs-4132	223	7	–	–	PUNCT
gs-4132	223	8	the	the	PRON
gs-4132	223	9	most	most	ADV
gs-4132	223	10	widely	widely	ADV
gs-4132	223	11	used	use	VERB
gs-4132	223	12	,	,	PUNCT
gs-4132	223	13	but	but	CCONJ
gs-4132	223	14	time	time	NOUN
gs-4132	223	15	-	-	PUNCT
gs-4132	223	16	consuming	consume	VERB
gs-4132	223	17	and	and	CCONJ
gs-4132	223	18	yields	yield	NOUN
gs-4132	223	19	heterogeneous	heterogeneous	ADJ
gs-4132	223	20	populations	population	NOUN
gs-4132	223	21	(	(	PUNCT
gs-4132	223	22	théry	théry	NOUN
gs-4132	223	23	et	et	PROPN
gs-4132	223	24	al	al	PROPN
gs-4132	223	25	.	.	PROPN
gs-4132	223	26	,	,	PUNCT
gs-4132	223	27	2006	2006	NUM
gs-4132	223	28	)	)	PUNCT
gs-4132	223	29	.	.	PUNCT
gs-4132	224	1	size	size	NOUN
gs-4132	224	2	-	-	PUNCT
gs-4132	224	3	exclusion	exclusion	NOUN
gs-4132	224	4	chromatography	chromatography	NOUN
gs-4132	224	5	(	(	PUNCT
gs-4132	224	6	sec	sec	PROPN
gs-4132	224	7	)	)	PUNCT
gs-4132	224	8	–	–	PUNCT
gs-4132	224	9	preserves	preserve	VERB
gs-4132	224	10	exosome	exosome	NOUN
gs-4132	224	11	integrity	integrity	NOUN
gs-4132	224	12	but	but	CCONJ
gs-4132	224	13	has	have	VERB
gs-4132	224	14	limited	limit	VERB
gs-4132	224	15	scalability	scalability	NOUN
gs-4132	224	16	(	(	PUNCT
gs-4132	224	17	böing	böe	VERB
gs-4132	224	18	et	et	PROPN
gs-4132	224	19	al	al	PROPN
gs-4132	224	20	.	.	PROPN
gs-4132	224	21	,	,	PUNCT
gs-4132	224	22	2014	2014	NUM
gs-4132	224	23	)	)	PUNCT
gs-4132	224	24	.	.	PUNCT
gs-4132	225	1	precipitation	precipitation	NOUN
gs-4132	225	2	-	-	PUNCT
gs-4132	225	3	based	base	VERB
gs-4132	225	4	methods	method	NOUN
gs-4132	225	5	–	–	PUNCT
gs-4132	225	6	convenient	convenient	ADJ
gs-4132	225	7	but	but	CCONJ
gs-4132	225	8	risk	risk	NOUN
gs-4132	225	9	protein	protein	NOUN
gs-4132	225	10	contamination	contamination	NOUN
gs-4132	225	11	(	(	PUNCT
gs-4132	225	12	helwa	helwa	PROPN
gs-4132	225	13	et	et	PROPN
gs-4132	225	14	al	al	PROPN
gs-4132	225	15	.	.	PROPN
gs-4132	225	16	,	,	PUNCT
gs-4132	225	17	2017	2017	NUM
gs-4132	225	18	)	)	PUNCT
gs-4132	225	19	.	.	PUNCT
gs-4132	226	1	tangential	tangential	ADJ
gs-4132	226	2	flow	flow	NOUN
gs-4132	226	3	filtration	filtration	NOUN
gs-4132	226	4	(	(	PUNCT
gs-4132	226	5	tff	tff	NOUN
gs-4132	226	6	)	)	PUNCT
gs-4132	226	7	–	–	PUNCT
gs-4132	226	8	promising	promise	VERB
gs-4132	226	9	for	for	ADP
gs-4132	226	10	scale	scale	NOUN
gs-4132	226	11	-	-	PUNCT
gs-4132	226	12	up	up	NOUN
gs-4132	226	13	but	but	CCONJ
gs-4132	226	14	requires	require	VERB
gs-4132	226	15	optimization	optimization	NOUN
gs-4132	226	16	(	(	PUNCT
gs-4132	226	17	busatto	busatto	PROPN
gs-4132	226	18	et	et	PROPN
gs-4132	226	19	al	al	PROPN
gs-4132	226	20	.	.	PROPN
gs-4132	226	21	,	,	PUNCT
gs-4132	226	22	2018	2018	NUM
gs-4132	226	23	)	)	PUNCT
gs-4132	226	24	.	.	PUNCT
gs-4132	227	1	standardized	standardize	VERB
gs-4132	227	2	,	,	PUNCT
gs-4132	227	3	gmp	gmp	NOUN
gs-4132	227	4	-	-	PUNCT
gs-4132	227	5	compliant	compliant	ADJ
gs-4132	227	6	methods	method	NOUN
gs-4132	227	7	are	be	AUX
gs-4132	227	8	urgently	urgently	ADV
gs-4132	227	9	needed	need	VERB
gs-4132	227	10	to	to	PART
gs-4132	227	11	produce	produce	VERB
gs-4132	227	12	homogeneous	homogeneous	ADJ
gs-4132	227	13	,	,	PUNCT
gs-4132	227	14	reproducible	reproducible	VERB
gs-4132	227	15	exosome	exosome	PROPN
gs-4132	227	16	preparations	preparation	NOUN
gs-4132	227	17	.	.	PUNCT
gs-4132	228	1	8.1.2	8.1.2	NUM
gs-4132	228	2	cargo	cargo	NOUN
gs-4132	228	3	heterogeneity	heterogeneity	NOUN
gs-4132	228	4	exosome	exosome	PROPN
gs-4132	228	5	content	content	PROPN
gs-4132	228	6	reflects	reflect	VERB
gs-4132	228	7	the	the	DET
gs-4132	228	8	parental	parental	ADJ
gs-4132	228	9	cell	cell	NOUN
gs-4132	228	10	type	type	NOUN
gs-4132	228	11	and	and	CCONJ
gs-4132	228	12	its	its	PRON
gs-4132	228	13	state	state	NOUN
gs-4132	228	14	.	.	PUNCT
gs-4132	229	1	tumor	tumor	NOUN
gs-4132	229	2	-	-	PUNCT
gs-4132	229	3	derived	derive	VERB
gs-4132	229	4	exosomes	exosome	NOUN
gs-4132	229	5	,	,	PUNCT
gs-4132	229	6	for	for	ADP
gs-4132	229	7	example	example	NOUN
gs-4132	229	8	,	,	PUNCT
gs-4132	229	9	may	may	AUX
gs-4132	229	10	carry	carry	VERB
gs-4132	229	11	oncogenic	oncogenic	ADJ
gs-4132	229	12	signals	signal	NOUN
gs-4132	229	13	.	.	PUNCT
gs-4132	230	1	this	this	PRON
gs-4132	230	2	raises	raise	VERB
gs-4132	230	3	biosafety	biosafety	NOUN
gs-4132	230	4	concerns	concern	NOUN
gs-4132	230	5	when	when	SCONJ
gs-4132	230	6	using	use	VERB
gs-4132	230	7	exosomes	exosome	NOUN
gs-4132	230	8	from	from	ADP
gs-4132	230	9	certain	certain	ADJ
gs-4132	230	10	sources	source	NOUN
gs-4132	230	11	(	(	PUNCT
gs-4132	230	12	kalluri	kalluri	PROPN
gs-4132	230	13	and	and	CCONJ
gs-4132	230	14	lebleu	lebleu	PROPN
gs-4132	230	15	,	,	PUNCT
gs-4132	230	16	2020	2020	NUM
gs-4132	230	17	)	)	PUNCT
gs-4132	230	18	.	.	PUNCT
gs-4132	231	1	engineering	engineering	NOUN
gs-4132	231	2	strategies	strategy	NOUN
gs-4132	231	3	to	to	PART
gs-4132	231	4	control	control	VERB
gs-4132	231	5	exosome	exosome	PROPN
gs-4132	231	6	cargo	cargo	PROPN
gs-4132	231	7	are	be	AUX
gs-4132	231	8	being	be	AUX
gs-4132	231	9	developed	develop	VERB
gs-4132	231	10	,	,	PUNCT
gs-4132	231	11	but	but	CCONJ
gs-4132	231	12	reproducibility	reproducibility	NOUN
gs-4132	231	13	remains	remain	VERB
gs-4132	231	14	limited	limited	ADJ
gs-4132	231	15	.	.	PUNCT
gs-4132	232	1	8.1.3	8.1.3	NUM
gs-4132	232	2	biodistribution	biodistribution	NOUN
gs-4132	232	3	and	and	CCONJ
gs-4132	232	4	off	off	ADP
gs-4132	232	5	-	-	PUNCT
gs-4132	232	6	target	target	NOUN
gs-4132	232	7	effects	effect	NOUN
gs-4132	232	8	although	although	SCONJ
gs-4132	232	9	exosomes	exosome	NOUN
gs-4132	232	10	exhibit	exhibit	VERB
gs-4132	232	11	natural	natural	ADJ
gs-4132	232	12	tropism	tropism	NOUN
gs-4132	232	13	,	,	PUNCT
gs-4132	232	14	biodistribution	biodistribution	NOUN
gs-4132	232	15	studies	study	NOUN
gs-4132	232	16	show	show	VERB
gs-4132	232	17	that	that	SCONJ
gs-4132	232	18	a	a	DET
gs-4132	232	19	significant	significant	ADJ
gs-4132	232	20	proportion	proportion	NOUN
gs-4132	232	21	accumulate	accumulate	NOUN
gs-4132	232	22	in	in	ADP
gs-4132	232	23	the	the	DET
gs-4132	232	24	liver	liver	NOUN
gs-4132	232	25	,	,	PUNCT
gs-4132	232	26	spleen	spleen	NOUN
gs-4132	232	27	,	,	PUNCT
gs-4132	232	28	and	and	CCONJ
gs-4132	232	29	lungs	lung	NOUN
gs-4132	232	30	(	(	PUNCT
gs-4132	232	31	wiklander	wiklander	X
gs-4132	232	32	et	et	PROPN
gs-4132	232	33	al	al	PROPN
gs-4132	232	34	.	.	PROPN
gs-4132	232	35	,	,	PUNCT
gs-4132	232	36	2015	2015	NUM
gs-4132	232	37	)	)	PUNCT
gs-4132	232	38	.	.	PUNCT
gs-4132	233	1	this	this	PRON
gs-4132	233	2	can	can	AUX
gs-4132	233	3	dilute	dilute	VERB
gs-4132	233	4	therapeutic	therapeutic	ADJ
gs-4132	233	5	efficacy	efficacy	NOUN
gs-4132	233	6	and	and	CCONJ
gs-4132	233	7	introduce	introduce	VERB
gs-4132	233	8	off	off	ADP
gs-4132	233	9	-	-	PUNCT
gs-4132	233	10	target	target	NOUN
gs-4132	233	11	effects	effect	NOUN
gs-4132	233	12	.	.	PUNCT
gs-4132	234	1	strategies	strategy	NOUN
gs-4132	234	2	such	such	ADJ
gs-4132	234	3	as	as	ADP
gs-4132	234	4	surface	surface	NOUN
gs-4132	234	5	engineering	engineering	NOUN
gs-4132	234	6	with	with	ADP
gs-4132	234	7	ligands	ligand	NOUN
gs-4132	234	8	or	or	CCONJ
gs-4132	234	9	peptides	peptide	NOUN
gs-4132	234	10	are	be	AUX
gs-4132	234	11	being	be	AUX
gs-4132	234	12	investigated	investigate	VERB
gs-4132	234	13	to	to	PART
gs-4132	234	14	improve	improve	VERB
gs-4132	234	15	targeting	target	VERB
gs-4132	234	16	precision	precision	NOUN
gs-4132	234	17	.	.	PUNCT
gs-4132	235	1	8.1.4	8.1.4	NUM
gs-4132	235	2	manufacturing	manufacturing	NOUN
gs-4132	235	3	costs	cost	VERB
gs-4132	235	4	large	large	ADJ
gs-4132	235	5	-	-	PUNCT
gs-4132	235	6	scale	scale	NOUN
gs-4132	235	7	exosome	exosome	NOUN
gs-4132	235	8	production	production	NOUN
gs-4132	235	9	requires	require	VERB
gs-4132	235	10	continuous	continuous	ADJ
gs-4132	235	11	cell	cell	NOUN
gs-4132	235	12	culture	culture	NOUN
gs-4132	235	13	,	,	PUNCT
gs-4132	235	14	expensive	expensive	ADJ
gs-4132	235	15	reagents	reagent	NOUN
gs-4132	235	16	,	,	PUNCT
gs-4132	235	17	and	and	CCONJ
gs-4132	235	18	labor	labor	NOUN
gs-4132	235	19	-	-	PUNCT
gs-4132	235	20	intensive	intensive	ADJ
gs-4132	235	21	purification	purification	NOUN
gs-4132	235	22	.	.	PUNCT
gs-4132	236	1	the	the	DET
gs-4132	236	2	cost	cost	NOUN
gs-4132	236	3	per	per	ADP
gs-4132	236	4	therapeutic	therapeutic	ADJ
gs-4132	236	5	dose	dose	NOUN
gs-4132	236	6	remains	remain	VERB
gs-4132	236	7	prohibitively	prohibitively	ADV
gs-4132	236	8	high	high	ADJ
gs-4132	236	9	compared	compare	VERB
gs-4132	236	10	to	to	ADP
gs-4132	236	11	synthetic	synthetic	ADJ
gs-4132	236	12	systems	system	NOUN
gs-4132	236	13	(	(	PUNCT
gs-4132	236	14	lener	lener	NOUN
gs-4132	236	15	et	et	PROPN
gs-4132	236	16	al	al	PROPN
gs-4132	236	17	.	.	PROPN
gs-4132	236	18	,	,	PUNCT
gs-4132	236	19	2015	2015	NUM
gs-4132	236	20	)	)	PUNCT
gs-4132	236	21	.	.	PUNCT
gs-4132	237	1	georgian	georgian	NOUN
gs-4132	237	2	scientists/	scientists/	NUM
gs-4132	237	3	.	.	PUNCT
gs-4132	238	1	7	7	NUM
gs-4132	238	2	n	n	DET
gs-4132	238	3	4	4	NUM
gs-4132	238	4	,	,	PUNCT
gs-4132	238	5	2025	2025	NUM
gs-4132	238	6	16	16	NUM
gs-4132	238	7	8.2	8.2	NUM
gs-4132	238	8	challenges	challenge	NOUN
gs-4132	238	9	in	in	ADP
gs-4132	238	10	liposome	liposome	NOUN
gs-4132	238	11	and	and	CCONJ
gs-4132	238	12	synthetic	synthetic	ADJ
gs-4132	238	13	nanoparticle	nanoparticle	NOUN
gs-4132	238	14	therapeutics	therapeutic	NOUN
gs-4132	238	15	8.2.1	8.2.1	ADP
gs-4132	238	16	immunogenicity	immunogenicity	NOUN
gs-4132	238	17	and	and	CCONJ
gs-4132	238	18	toxicity	toxicity	NOUN
gs-4132	238	19	liposomes	liposome	NOUN
gs-4132	238	20	can	can	AUX
gs-4132	238	21	trigger	trigger	VERB
gs-4132	238	22	complement	complement	NOUN
gs-4132	238	23	activation	activation	NOUN
gs-4132	238	24	-	-	PUNCT
gs-4132	238	25	related	relate	VERB
gs-4132	238	26	pseudoallergy	pseudoallergy	NOUN
gs-4132	238	27	(	(	PUNCT
gs-4132	238	28	carpa	carpa	PROPN
gs-4132	238	29	)	)	PUNCT
gs-4132	238	30	,	,	PUNCT
gs-4132	238	31	leading	lead	VERB
gs-4132	238	32	to	to	ADP
gs-4132	238	33	hypersensitivity	hypersensitivity	NOUN
gs-4132	238	34	reactions	reaction	NOUN
gs-4132	238	35	(	(	PUNCT
gs-4132	238	36	szebeni	szebeni	NOUN
gs-4132	238	37	,	,	PUNCT
gs-4132	238	38	2005	2005	NUM
gs-4132	238	39	)	)	PUNCT
gs-4132	238	40	.	.	PUNCT
gs-4132	239	1	polymeric	polymeric	ADJ
gs-4132	239	2	and	and	CCONJ
gs-4132	239	3	inorganic	inorganic	ADJ
gs-4132	239	4	nanoparticles	nanoparticle	NOUN
gs-4132	239	5	raise	raise	VERB
gs-4132	239	6	additional	additional	ADJ
gs-4132	239	7	concerns	concern	NOUN
gs-4132	239	8	about	about	ADP
gs-4132	239	9	long	long	ADJ
gs-4132	239	10	-	-	PUNCT
gs-4132	239	11	term	term	NOUN
gs-4132	239	12	accumulation	accumulation	NOUN
gs-4132	239	13	and	and	CCONJ
gs-4132	239	14	toxicity	toxicity	NOUN
gs-4132	239	15	(	(	PUNCT
gs-4132	239	16	elsabahy	elsabahy	NOUN
gs-4132	239	17	and	and	CCONJ
gs-4132	239	18	wooley	wooley	PROPN
gs-4132	239	19	,	,	PUNCT
gs-4132	239	20	2012	2012	NUM
gs-4132	239	21	)	)	PUNCT
gs-4132	239	22	.	.	PUNCT
gs-4132	240	1	8.2.2	8.2.2	NUM
gs-4132	240	2	limited	limited	ADJ
gs-4132	240	3	targeting	target	VERB
gs-4132	240	4	without	without	ADP
gs-4132	240	5	active	active	ADJ
gs-4132	240	6	modification	modification	NOUN
gs-4132	240	7	,	,	PUNCT
gs-4132	240	8	liposomes	liposome	NOUN
gs-4132	240	9	distribute	distribute	VERB
gs-4132	240	10	passively	passively	ADV
gs-4132	240	11	via	via	ADP
gs-4132	240	12	the	the	DET
gs-4132	240	13	enhanced	enhanced	ADJ
gs-4132	240	14	permeability	permeability	NOUN
gs-4132	240	15	and	and	CCONJ
gs-4132	240	16	retention	retention	NOUN
gs-4132	240	17	(	(	PUNCT
gs-4132	240	18	epr	epr	ADJ
gs-4132	240	19	)	)	PUNCT
gs-4132	240	20	effect	effect	NOUN
gs-4132	240	21	(	(	PUNCT
gs-4132	240	22	matsumura	matsumura	ADJ
gs-4132	240	23	and	and	CCONJ
gs-4132	240	24	maeda	maeda	PROPN
gs-4132	240	25	,	,	PUNCT
gs-4132	240	26	1986	1986	NUM
gs-4132	240	27	)	)	PUNCT
gs-4132	240	28	.	.	PUNCT
gs-4132	241	1	however	however	ADV
gs-4132	241	2	,	,	PUNCT
gs-4132	241	3	epr	epr	PROPN
gs-4132	241	4	is	be	AUX
gs-4132	241	5	highly	highly	ADV
gs-4132	241	6	variable	variable	ADJ
gs-4132	241	7	between	between	ADP
gs-4132	241	8	tumors	tumor	NOUN
gs-4132	241	9	and	and	CCONJ
gs-4132	241	10	patients	patient	NOUN
gs-4132	241	11	(	(	PUNCT
gs-4132	241	12	danhier	danhier	NOUN
gs-4132	241	13	,	,	PUNCT
gs-4132	241	14	2016	2016	NUM
gs-4132	241	15	)	)	PUNCT
gs-4132	241	16	.	.	PUNCT
gs-4132	242	1	this	this	DET
gs-4132	242	2	variability	variability	NOUN
gs-4132	242	3	limits	limit	VERB
gs-4132	242	4	consistent	consistent	ADJ
gs-4132	242	5	clinical	clinical	ADJ
gs-4132	242	6	efficacy	efficacy	NOUN
gs-4132	242	7	.	.	PUNCT
gs-4132	243	1	8.2.3	8.2.3	NUM
gs-4132	243	2	scalability	scalability	NOUN
gs-4132	243	3	vs.	vs.	ADP
gs-4132	243	4	complexity	complexity	NOUN
gs-4132	243	5	while	while	SCONJ
gs-4132	243	6	liposomes	liposome	NOUN
gs-4132	243	7	are	be	AUX
gs-4132	243	8	relatively	relatively	ADV
gs-4132	243	9	easy	easy	ADJ
gs-4132	243	10	to	to	PART
gs-4132	243	11	scale	scale	VERB
gs-4132	243	12	,	,	PUNCT
gs-4132	243	13	more	more	ADV
gs-4132	243	14	advanced	advanced	ADJ
gs-4132	243	15	designs	design	NOUN
gs-4132	243	16	(	(	PUNCT
gs-4132	243	17	stimuliresponsive	stimuliresponsive	ADJ
gs-4132	243	18	or	or	CCONJ
gs-4132	243	19	ligand	ligand	NOUN
gs-4132	243	20	-	-	PUNCT
gs-4132	243	21	targeted	target	VERB
gs-4132	243	22	liposomes	liposome	NOUN
gs-4132	243	23	)	)	PUNCT
gs-4132	243	24	introduce	introduce	VERB
gs-4132	243	25	complexity	complexity	NOUN
gs-4132	243	26	in	in	ADP
gs-4132	243	27	manufacturing	manufacturing	NOUN
gs-4132	243	28	and	and	CCONJ
gs-4132	243	29	regulatory	regulatory	ADJ
gs-4132	243	30	approval	approval	NOUN
gs-4132	243	31	.	.	PUNCT
gs-4132	244	1	8.3	8.3	NUM
gs-4132	244	2	regulatory	regulatory	ADJ
gs-4132	244	3	barriers	barrier	NOUN
gs-4132	244	4	8.3.1	8.3.1	NUM
gs-4132	244	5	exosomes	exosome	NOUN
gs-4132	244	6	currently	currently	ADV
gs-4132	244	7	,	,	PUNCT
gs-4132	244	8	there	there	PRON
gs-4132	244	9	are	be	VERB
gs-4132	244	10	no	no	DET
gs-4132	244	11	universally	universally	ADV
gs-4132	244	12	accepted	accept	VERB
gs-4132	244	13	regulatory	regulatory	ADJ
gs-4132	244	14	guidelines	guideline	NOUN
gs-4132	244	15	for	for	ADP
gs-4132	244	16	exosome	exosome	NOUN
gs-4132	244	17	therapeutics	therapeutic	NOUN
gs-4132	244	18	.	.	PUNCT
gs-4132	245	1	issues	issue	NOUN
gs-4132	245	2	include	include	VERB
gs-4132	245	3	:	:	PUNCT
gs-4132	245	4	classification	classification	NOUN
gs-4132	245	5	:	:	PUNCT
gs-4132	245	6	are	be	AUX
gs-4132	245	7	exosomes	exosome	NOUN
gs-4132	245	8	drugs	drug	NOUN
gs-4132	245	9	,	,	PUNCT
gs-4132	245	10	biologics	biologic	NOUN
gs-4132	245	11	,	,	PUNCT
gs-4132	245	12	or	or	CCONJ
gs-4132	245	13	advanced	advanced	ADJ
gs-4132	245	14	therapy	therapy	NOUN
gs-4132	245	15	medicinal	medicinal	ADJ
gs-4132	245	16	products	product	NOUN
gs-4132	245	17	(	(	PUNCT
gs-4132	245	18	atmps	atmp	NOUN
gs-4132	245	19	)	)	PUNCT
gs-4132	245	20	?	?	PUNCT
gs-4132	246	1	potency	potency	NOUN
gs-4132	246	2	assays	assay	VERB
gs-4132	246	3	:	:	PUNCT
gs-4132	246	4	lack	lack	NOUN
gs-4132	246	5	of	of	ADP
gs-4132	246	6	standardized	standardized	ADJ
gs-4132	246	7	assays	assay	NOUN
gs-4132	246	8	to	to	PART
gs-4132	246	9	evaluate	evaluate	VERB
gs-4132	246	10	therapeutic	therapeutic	ADJ
gs-4132	246	11	efficacy	efficacy	NOUN
gs-4132	246	12	.	.	PUNCT
gs-4132	247	1	batch	batch	NOUN
gs-4132	247	2	variability	variability	NOUN
gs-4132	247	3	:	:	PUNCT
gs-4132	247	4	differences	difference	NOUN
gs-4132	247	5	between	between	ADP
gs-4132	247	6	exosome	exosome	PROPN
gs-4132	247	7	batches	batch	NOUN
gs-4132	247	8	complicate	complicate	VERB
gs-4132	247	9	quality	quality	NOUN
gs-4132	247	10	control	control	NOUN
gs-4132	247	11	(	(	PUNCT
gs-4132	247	12	reiner	reiner	NOUN
gs-4132	247	13	et	et	PROPN
gs-4132	247	14	al	al	PROPN
gs-4132	247	15	.	.	PROPN
gs-4132	247	16	,	,	PUNCT
gs-4132	247	17	2017	2017	NUM
gs-4132	247	18	)	)	PUNCT
gs-4132	247	19	.	.	PUNCT
gs-4132	248	1	8.3.2	8.3.2	NUM
gs-4132	248	2	liposomes	liposome	NOUN
gs-4132	248	3	liposomes	liposome	NOUN
gs-4132	248	4	benefit	benefit	VERB
gs-4132	248	5	from	from	ADP
gs-4132	248	6	established	establish	VERB
gs-4132	248	7	regulatory	regulatory	ADJ
gs-4132	248	8	pathways	pathway	NOUN
gs-4132	248	9	.	.	PUNCT
gs-4132	249	1	however	however	ADV
gs-4132	249	2	,	,	PUNCT
gs-4132	249	3	approval	approval	NOUN
gs-4132	249	4	remains	remain	VERB
gs-4132	249	5	complex	complex	ADJ
gs-4132	249	6	,	,	PUNCT
gs-4132	249	7	requiring	require	VERB
gs-4132	249	8	detailed	detailed	ADJ
gs-4132	249	9	data	datum	NOUN
gs-4132	249	10	on	on	ADP
gs-4132	249	11	lipid	lipid	ADJ
gs-4132	249	12	composition	composition	NOUN
gs-4132	249	13	,	,	PUNCT
gs-4132	249	14	stability	stability	NOUN
gs-4132	249	15	,	,	PUNCT
gs-4132	249	16	biodistribution	biodistribution	NOUN
gs-4132	249	17	,	,	PUNCT
gs-4132	249	18	and	and	CCONJ
gs-4132	249	19	immunogenicity	immunogenicity	NOUN
gs-4132	249	20	(	(	PUNCT
gs-4132	249	21	allen	allen	NOUN
gs-4132	249	22	and	and	CCONJ
gs-4132	249	23	cullis	cullis	PROPN
gs-4132	249	24	,	,	PUNCT
gs-4132	249	25	2013	2013	NUM
gs-4132	249	26	)	)	PUNCT
gs-4132	249	27	.	.	PUNCT
gs-4132	250	1	georgian	georgian	NOUN
gs-4132	250	2	scientists/	scientists/	NUM
gs-4132	250	3	.	.	PUNCT
gs-4132	251	1	7	7	NUM
gs-4132	251	2	n	n	DET
gs-4132	251	3	4	4	NUM
gs-4132	251	4	,	,	PUNCT
gs-4132	251	5	2025	2025	NUM
gs-4132	251	6	17	17	NUM
gs-4132	251	7	8.4	8.4	NUM
gs-4132	251	8	future	future	ADJ
gs-4132	251	9	directions	direction	NOUN
gs-4132	251	10	8.4.1	8.4.1	NUM
gs-4132	251	11	hybrid	hybrid	NOUN
gs-4132	251	12	systems	system	NOUN
gs-4132	251	13	exosome	exosome	NOUN
gs-4132	251	14	-	-	PUNCT
gs-4132	251	15	liposome	liposome	NOUN
gs-4132	251	16	hybrids	hybrid	NOUN
gs-4132	251	17	combine	combine	VERB
gs-4132	251	18	natural	natural	ADJ
gs-4132	251	19	targeting	target	VERB
gs-4132	251	20	with	with	ADP
gs-4132	251	21	scalable	scalable	ADJ
gs-4132	251	22	production	production	NOUN
gs-4132	251	23	.	.	PUNCT
gs-4132	252	1	early	early	ADJ
gs-4132	252	2	studies	study	NOUN
gs-4132	252	3	show	show	VERB
gs-4132	252	4	that	that	SCONJ
gs-4132	252	5	hybrid	hybrid	ADJ
gs-4132	252	6	vesicles	vesicle	NOUN
gs-4132	252	7	can	can	AUX
gs-4132	252	8	deliver	deliver	VERB
gs-4132	252	9	sirna	sirna	PROPN
gs-4132	252	10	and	and	CCONJ
gs-4132	252	11	chemotherapeutics	chemotherapeutic	NOUN
gs-4132	252	12	with	with	ADP
gs-4132	252	13	enhanced	enhanced	ADJ
gs-4132	252	14	efficiency	efficiency	NOUN
gs-4132	252	15	(	(	PUNCT
gs-4132	252	16	lin	lin	PROPN
gs-4132	252	17	et	et	PROPN
gs-4132	252	18	al	al	PROPN
gs-4132	252	19	.	.	PROPN
gs-4132	252	20	,	,	PUNCT
gs-4132	252	21	2018	2018	NUM
gs-4132	252	22	)	)	PUNCT
gs-4132	252	23	.	.	PUNCT
gs-4132	253	1	8.4.2	8.4.2	NUM
gs-4132	253	2	synthetic	synthetic	ADJ
gs-4132	253	3	exosome	exosome	NOUN
gs-4132	253	4	-	-	PUNCT
gs-4132	253	5	mimetics	mimetic	NOUN
gs-4132	253	6	artificial	artificial	ADJ
gs-4132	253	7	vesicles	vesicle	NOUN
gs-4132	253	8	mimicking	mimic	VERB
gs-4132	253	9	exosomal	exosomal	ADJ
gs-4132	253	10	composition	composition	NOUN
gs-4132	253	11	are	be	AUX
gs-4132	253	12	emerging	emerge	VERB
gs-4132	253	13	as	as	ADP
gs-4132	253	14	next	next	ADJ
gs-4132	253	15	-	-	PUNCT
gs-4132	253	16	generation	generation	NOUN
gs-4132	253	17	platforms	platform	NOUN
gs-4132	253	18	.	.	PUNCT
gs-4132	254	1	jang	jang	PROPN
gs-4132	254	2	et	et	PROPN
gs-4132	254	3	al	al	PROPN
gs-4132	254	4	.	.	PROPN
gs-4132	255	1	(	(	PUNCT
gs-4132	255	2	2013	2013	NUM
gs-4132	255	3	)	)	PUNCT
gs-4132	255	4	demonstrated	demonstrate	VERB
gs-4132	255	5	exosome	exosome	ADJ
gs-4132	255	6	-	-	PUNCT
gs-4132	255	7	mimetic	mimetic	ADJ
gs-4132	255	8	nanovesicles	nanovesicle	NOUN
gs-4132	255	9	produced	produce	VERB
gs-4132	255	10	by	by	ADP
gs-4132	255	11	extrusion	extrusion	NOUN
gs-4132	255	12	,	,	PUNCT
gs-4132	255	13	capable	capable	ADJ
gs-4132	255	14	of	of	ADP
gs-4132	255	15	delivering	deliver	VERB
gs-4132	255	16	drugs	drug	NOUN
gs-4132	255	17	to	to	ADP
gs-4132	255	18	tumors	tumor	NOUN
gs-4132	255	19	at	at	ADP
gs-4132	255	20	scale	scale	NOUN
gs-4132	255	21	.	.	PUNCT
gs-4132	256	1	8.4.3	8.4.3	NUM
gs-4132	256	2	personalized	personalized	ADJ
gs-4132	256	3	medicine	medicine	NOUN
gs-4132	256	4	autologous	autologous	ADJ
gs-4132	256	5	exosomes	exosome	NOUN
gs-4132	256	6	derived	derive	VERB
gs-4132	256	7	from	from	ADP
gs-4132	256	8	a	a	DET
gs-4132	256	9	patient	patient	NOUN
gs-4132	256	10	’s	’s	PART
gs-4132	256	11	own	own	ADJ
gs-4132	256	12	cells	cell	NOUN
gs-4132	256	13	offer	offer	VERB
gs-4132	256	14	a	a	DET
gs-4132	256	15	personalized	personalize	VERB
gs-4132	256	16	,	,	PUNCT
gs-4132	256	17	lowimmunogenicity	lowimmunogenicity	NOUN
gs-4132	256	18	therapeutic	therapeutic	ADJ
gs-4132	256	19	option	option	NOUN
gs-4132	256	20	.	.	PUNCT
gs-4132	257	1	for	for	ADP
gs-4132	257	2	instance	instance	NOUN
gs-4132	257	3	,	,	PUNCT
gs-4132	257	4	tumor	tumor	NOUN
gs-4132	257	5	-	-	PUNCT
gs-4132	257	6	derived	derive	VERB
gs-4132	257	7	exosomes	exosome	NOUN
gs-4132	257	8	engineered	engineer	VERB
gs-4132	257	9	to	to	PART
gs-4132	257	10	present	present	ADJ
gs-4132	257	11	antigens	antigen	NOUN
gs-4132	257	12	could	could	AUX
gs-4132	257	13	serve	serve	VERB
gs-4132	257	14	as	as	ADP
gs-4132	257	15	personalized	personalize	VERB
gs-4132	257	16	cancer	cancer	NOUN
gs-4132	257	17	vaccines	vaccine	NOUN
gs-4132	257	18	(	(	PUNCT
gs-4132	257	19	zitvogel	zitvogel	NOUN
gs-4132	257	20	et	et	PROPN
gs-4132	257	21	al	al	PROPN
gs-4132	257	22	.	.	PROPN
gs-4132	257	23	,	,	PUNCT
gs-4132	257	24	1998	1998	NUM
gs-4132	257	25	)	)	PUNCT
gs-4132	257	26	.	.	PUNCT
gs-4132	258	1	8.4.4	8.4.4	NUM
gs-4132	258	2	gene	gene	NOUN
gs-4132	258	3	and	and	CCONJ
gs-4132	258	4	rna	rna	NOUN
gs-4132	258	5	therapeutics	therapeutic	NOUN
gs-4132	258	6	exosomes	exosome	NOUN
gs-4132	258	7	and	and	CCONJ
gs-4132	258	8	lipid	lipid	NOUN
gs-4132	258	9	nanoparticles	nanoparticle	NOUN
gs-4132	258	10	have	have	AUX
gs-4132	258	11	already	already	ADV
gs-4132	258	12	proven	prove	VERB
gs-4132	258	13	their	their	PRON
gs-4132	258	14	value	value	NOUN
gs-4132	258	15	in	in	ADP
gs-4132	258	16	rna	rna	NOUN
gs-4132	258	17	-	-	PUNCT
gs-4132	258	18	based	base	VERB
gs-4132	258	19	medicine	medicine	NOUN
gs-4132	258	20	,	,	PUNCT
gs-4132	258	21	highlighted	highlight	VERB
gs-4132	258	22	by	by	ADP
gs-4132	258	23	the	the	DET
gs-4132	258	24	success	success	NOUN
gs-4132	258	25	of	of	ADP
gs-4132	258	26	lipid	lipid	ADJ
gs-4132	258	27	nanoparticle	nanoparticle	NOUN
gs-4132	258	28	(	(	PUNCT
gs-4132	258	29	lnp)-based	lnp)-base	VERB
gs-4132	258	30	mrna	mrna	NOUN
gs-4132	258	31	vaccines	vaccine	NOUN
gs-4132	258	32	for	for	ADP
gs-4132	258	33	covid-19	covid-19	PROPN
gs-4132	258	34	(	(	PUNCT
gs-4132	258	35	sahin	sahin	PROPN
gs-4132	258	36	et	et	PROPN
gs-4132	258	37	al	al	PROPN
gs-4132	258	38	.	.	PROPN
gs-4132	258	39	,	,	PUNCT
gs-4132	258	40	2020	2020	NUM
gs-4132	258	41	)	)	PUNCT
gs-4132	258	42	.	.	PUNCT
gs-4132	259	1	exosomes	exosome	NOUN
gs-4132	259	2	could	could	AUX
gs-4132	259	3	serve	serve	VERB
gs-4132	259	4	as	as	ADP
gs-4132	259	5	next	next	ADJ
gs-4132	259	6	-	-	PUNCT
gs-4132	259	7	generation	generation	NOUN
gs-4132	259	8	carriers	carrier	NOUN
gs-4132	259	9	for	for	ADP
gs-4132	259	10	sirna	sirna	PROPN
gs-4132	259	11	,	,	PUNCT
gs-4132	259	12	mirna	mirna	PROPN
gs-4132	259	13	,	,	PUNCT
gs-4132	259	14	and	and	CCONJ
gs-4132	259	15	crispr	crispr	ADJ
gs-4132	259	16	-	-	PUNCT
gs-4132	259	17	cas	cas	NOUN
gs-4132	259	18	systems	system	NOUN
gs-4132	259	19	(	(	PUNCT
gs-4132	259	20	gilligan	gilligan	NOUN
gs-4132	259	21	and	and	CCONJ
gs-4132	259	22	dwyer	dwyer	PROPN
gs-4132	259	23	,	,	PUNCT
gs-4132	259	24	2017	2017	NUM
gs-4132	259	25	)	)	PUNCT
gs-4132	259	26	.	.	PUNCT
gs-4132	260	1	8.4.5	8.4.5	NUM
gs-4132	260	2	artificial	artificial	ADJ
gs-4132	260	3	intelligence	intelligence	NOUN
gs-4132	260	4	in	in	ADP
gs-4132	260	5	nanomedicine	nanomedicine	ADJ
gs-4132	260	6	design	design	NOUN
gs-4132	260	7	ai	ai	NOUN
gs-4132	260	8	and	and	CCONJ
gs-4132	260	9	machine	machine	NOUN
gs-4132	260	10	learning	learning	NOUN
gs-4132	260	11	are	be	AUX
gs-4132	260	12	increasingly	increasingly	ADV
gs-4132	260	13	applied	apply	VERB
gs-4132	260	14	to	to	PART
gs-4132	260	15	predict	predict	VERB
gs-4132	260	16	nanoparticle	nanoparticle	NOUN
gs-4132	260	17	–	–	PUNCT
gs-4132	260	18	biological	biological	ADJ
gs-4132	260	19	interactions	interaction	NOUN
gs-4132	260	20	,	,	PUNCT
gs-4132	260	21	optimize	optimize	NOUN
gs-4132	260	22	formulation	formulation	NOUN
gs-4132	260	23	,	,	PUNCT
gs-4132	260	24	and	and	CCONJ
gs-4132	260	25	identify	identify	VERB
gs-4132	260	26	therapeutic	therapeutic	ADJ
gs-4132	260	27	targets	target	NOUN
gs-4132	260	28	(	(	PUNCT
gs-4132	260	29	costa	costa	PROPN
gs-4132	260	30	et	et	PROPN
gs-4132	260	31	al	al	PROPN
gs-4132	260	32	.	.	PROPN
gs-4132	260	33	,	,	PUNCT
gs-4132	260	34	2020	2020	NUM
gs-4132	260	35	)	)	PUNCT
gs-4132	260	36	.	.	PUNCT
gs-4132	261	1	this	this	DET
gs-4132	261	2	integration	integration	NOUN
gs-4132	261	3	could	could	AUX
gs-4132	261	4	accelerate	accelerate	VERB
gs-4132	261	5	development	development	NOUN
gs-4132	261	6	and	and	CCONJ
gs-4132	261	7	reduce	reduce	VERB
gs-4132	261	8	trial	trial	NOUN
gs-4132	261	9	-	-	PUNCT
gs-4132	261	10	and	and	CCONJ
gs-4132	261	11	-	-	PUNCT
gs-4132	261	12	error	error	NOUN
gs-4132	261	13	in	in	ADP
gs-4132	261	14	nanomedicine	nanomedicine	NOUN
gs-4132	261	15	.	.	PUNCT
gs-4132	262	1	9	9	X
gs-4132	262	2	.	.	X
gs-4132	262	3	discussion	discussion	NOUN
gs-4132	262	4	the	the	DET
gs-4132	262	5	field	field	NOUN
gs-4132	262	6	of	of	ADP
gs-4132	262	7	nanomedicine	nanomedicine	NOUN
gs-4132	262	8	has	have	AUX
gs-4132	262	9	experienced	experience	VERB
gs-4132	262	10	a	a	DET
gs-4132	262	11	rapid	rapid	ADJ
gs-4132	262	12	evolution	evolution	NOUN
gs-4132	262	13	in	in	ADP
gs-4132	262	14	recent	recent	ADJ
gs-4132	262	15	years	year	NOUN
gs-4132	262	16	,	,	PUNCT
gs-4132	262	17	propelled	propel	VERB
gs-4132	262	18	by	by	ADP
gs-4132	262	19	advances	advance	NOUN
gs-4132	262	20	in	in	ADP
gs-4132	262	21	molecular	molecular	ADJ
gs-4132	262	22	biology	biology	NOUN
gs-4132	262	23	,	,	PUNCT
gs-4132	262	24	material	material	NOUN
gs-4132	262	25	science	science	NOUN
gs-4132	262	26	,	,	PUNCT
gs-4132	262	27	and	and	CCONJ
gs-4132	262	28	pharmaceutical	pharmaceutical	NOUN
gs-4132	262	29	engineering	engineering	NOUN
gs-4132	262	30	.	.	PUNCT
gs-4132	263	1	among	among	ADP
gs-4132	263	2	the	the	DET
gs-4132	263	3	most	most	ADV
gs-4132	263	4	intriguing	intriguing	ADJ
gs-4132	263	5	developments	development	NOUN
gs-4132	263	6	is	be	AUX
gs-4132	263	7	the	the	DET
gs-4132	263	8	study	study	NOUN
gs-4132	263	9	of	of	ADP
gs-4132	263	10	exosomes	exosome	NOUN
gs-4132	263	11	and	and	CCONJ
gs-4132	263	12	other	other	ADJ
gs-4132	263	13	small	small	ADJ
gs-4132	263	14	particle	particle	NOUN
gs-4132	263	15	-	-	PUNCT
gs-4132	263	16	based	base	VERB
gs-4132	263	17	therapeutics	therapeutic	NOUN
gs-4132	263	18	,	,	PUNCT
gs-4132	263	19	which	which	PRON
gs-4132	263	20	have	have	AUX
gs-4132	263	21	emerged	emerge	VERB
gs-4132	263	22	as	as	ADP
gs-4132	263	23	promising	promise	VERB
gs-4132	263	24	vectors	vector	NOUN
gs-4132	263	25	for	for	ADP
gs-4132	263	26	drug	drug	NOUN
gs-4132	263	27	delivery	delivery	NOUN
gs-4132	263	28	,	,	PUNCT
gs-4132	263	29	gene	gene	NOUN
gs-4132	263	30	therapy	therapy	NOUN
gs-4132	263	31	,	,	PUNCT
gs-4132	263	32	and	and	CCONJ
gs-4132	263	33	immunomodulation	immunomodulation	NOUN
gs-4132	263	34	.	.	PUNCT
gs-4132	264	1	exosomes	exosome	NOUN
gs-4132	264	2	,	,	PUNCT
gs-4132	264	3	naturally	naturally	ADV
gs-4132	264	4	occurring	occur	VERB
gs-4132	264	5	extracellular	extracellular	ADJ
gs-4132	264	6	vesicles	vesicle	NOUN
gs-4132	264	7	,	,	PUNCT
gs-4132	264	8	are	be	AUX
gs-4132	264	9	released	release	VERB
gs-4132	264	10	by	by	ADP
gs-4132	264	11	virtually	virtually	ADV
gs-4132	264	12	all	all	PRON
gs-4132	264	13	cell	cell	NOUN
gs-4132	264	14	types	type	NOUN
gs-4132	264	15	and	and	CCONJ
gs-4132	264	16	function	function	NOUN
gs-4132	264	17	as	as	ADP
gs-4132	264	18	critical	critical	ADJ
gs-4132	264	19	mediators	mediator	NOUN
gs-4132	264	20	of	of	ADP
gs-4132	264	21	intercellular	intercellular	ADJ
gs-4132	264	22	communication	communication	NOUN
gs-4132	264	23	.	.	PUNCT
gs-4132	265	1	their	their	PRON
gs-4132	265	2	unique	unique	ADJ
gs-4132	265	3	biological	biological	ADJ
gs-4132	265	4	origin	origin	NOUN
gs-4132	265	5	confers	confer	NOUN
gs-4132	265	6	remarkable	remarkable	ADJ
gs-4132	265	7	advantages	advantage	NOUN
gs-4132	265	8	,	,	PUNCT
gs-4132	265	9	including	include	VERB
gs-4132	265	10	innate	innate	ADJ
gs-4132	265	11	biocompatibility	biocompatibility	NOUN
gs-4132	265	12	,	,	PUNCT
gs-4132	265	13	low	low	ADJ
gs-4132	265	14	immunogenicity	immunogenicity	NOUN
gs-4132	265	15	,	,	PUNCT
gs-4132	265	16	and	and	CCONJ
gs-4132	265	17	the	the	DET
gs-4132	265	18	ability	ability	NOUN
gs-4132	265	19	to	to	PART
gs-4132	265	20	cross	cross	VERB
gs-4132	265	21	biological	biological	ADJ
gs-4132	265	22	barriers	barrier	NOUN
gs-4132	265	23	such	such	ADJ
gs-4132	265	24	as	as	ADP
gs-4132	265	25	the	the	DET
gs-4132	265	26	blood	blood	NOUN
gs-4132	265	27	-	-	PUNCT
gs-4132	265	28	brain	brain	NOUN
gs-4132	265	29	barrier	barrier	NOUN
gs-4132	265	30	.	.	PUNCT
gs-4132	266	1	this	this	DET
gs-4132	266	2	intrinsic	intrinsic	ADJ
gs-4132	266	3	capacity	capacity	NOUN
gs-4132	266	4	to	to	PART
gs-4132	266	5	shuttle	shuttle	VERB
gs-4132	266	6	nucleic	nucleic	ADJ
gs-4132	266	7	acids	acid	NOUN
gs-4132	266	8	,	,	PUNCT
gs-4132	266	9	proteins	protein	NOUN
gs-4132	266	10	,	,	PUNCT
gs-4132	266	11	and	and	CCONJ
gs-4132	266	12	lipids	lipid	NOUN
gs-4132	266	13	between	between	ADP
gs-4132	266	14	cells	cell	NOUN
gs-4132	266	15	has	have	AUX
gs-4132	266	16	positioned	position	VERB
gs-4132	266	17	exosomes	exosome	NOUN
gs-4132	266	18	as	as	ADP
gs-4132	266	19	highly	highly	ADV
gs-4132	266	20	versatile	versatile	ADJ
gs-4132	266	21	therapeutic	therapeutic	ADJ
gs-4132	266	22	carriers	carrier	NOUN
gs-4132	266	23	,	,	PUNCT
gs-4132	266	24	capable	capable	ADJ
gs-4132	266	25	of	of	ADP
gs-4132	266	26	modulating	modulate	VERB
gs-4132	266	27	cellular	cellular	ADJ
gs-4132	266	28	phenotypes	phenotype	NOUN
gs-4132	266	29	and	and	CCONJ
gs-4132	266	30	influencing	influence	VERB
gs-4132	266	31	complex	complex	ADJ
gs-4132	266	32	physiological	physiological	ADJ
gs-4132	266	33	processes	process	NOUN
gs-4132	266	34	.	.	PUNCT
gs-4132	267	1	georgian	georgian	NOUN
gs-4132	267	2	scientists/	scientists/	NUM
gs-4132	267	3	.	.	PUNCT
gs-4132	268	1	7	7	NUM
gs-4132	268	2	n	n	DET
gs-4132	268	3	4	4	NUM
gs-4132	268	4	,	,	PUNCT
gs-4132	268	5	2025	2025	NUM
gs-4132	268	6	18	18	NUM
gs-4132	268	7	parallel	parallel	NOUN
gs-4132	268	8	to	to	ADP
gs-4132	268	9	the	the	DET
gs-4132	268	10	exploration	exploration	NOUN
gs-4132	268	11	of	of	ADP
gs-4132	268	12	exosomes	exosome	NOUN
gs-4132	268	13	,	,	PUNCT
gs-4132	268	14	synthetic	synthetic	ADJ
gs-4132	268	15	nanocarriers	nanocarrier	NOUN
gs-4132	268	16	—	—	PUNCT
gs-4132	268	17	including	include	VERB
gs-4132	268	18	liposomes	liposome	NOUN
gs-4132	268	19	,	,	PUNCT
gs-4132	268	20	polymeric	polymeric	ADJ
gs-4132	268	21	nanoparticles	nanoparticle	NOUN
gs-4132	268	22	,	,	PUNCT
gs-4132	268	23	dendrimers	dendrimer	NOUN
gs-4132	268	24	,	,	PUNCT
gs-4132	268	25	and	and	CCONJ
gs-4132	268	26	inorganic	inorganic	ADJ
gs-4132	268	27	nanoparticles	nanoparticle	NOUN
gs-4132	268	28	—	—	PUNCT
gs-4132	268	29	have	have	AUX
gs-4132	268	30	been	be	AUX
gs-4132	268	31	extensively	extensively	ADV
gs-4132	268	32	developed	develop	VERB
gs-4132	268	33	to	to	PART
gs-4132	268	34	deliver	deliver	VERB
gs-4132	268	35	therapeutic	therapeutic	ADJ
gs-4132	268	36	payloads	payload	NOUN
gs-4132	268	37	with	with	ADP
gs-4132	268	38	precision	precision	NOUN
gs-4132	268	39	.	.	PUNCT
gs-4132	269	1	these	these	DET
gs-4132	269	2	synthetic	synthetic	ADJ
gs-4132	269	3	platforms	platform	NOUN
gs-4132	269	4	offer	offer	VERB
gs-4132	269	5	unparalleled	unparalleled	ADJ
gs-4132	269	6	control	control	NOUN
gs-4132	269	7	over	over	ADP
gs-4132	269	8	physicochemical	physicochemical	ADJ
gs-4132	269	9	properties	property	NOUN
gs-4132	269	10	,	,	PUNCT
gs-4132	269	11	such	such	ADJ
gs-4132	269	12	as	as	ADP
gs-4132	269	13	particle	particle	NOUN
gs-4132	269	14	size	size	NOUN
gs-4132	269	15	,	,	PUNCT
gs-4132	269	16	surface	surface	NOUN
gs-4132	269	17	charge	charge	NOUN
gs-4132	269	18	,	,	PUNCT
gs-4132	269	19	and	and	CCONJ
gs-4132	269	20	functionalization	functionalization	NOUN
gs-4132	269	21	with	with	ADP
gs-4132	269	22	targeting	target	VERB
gs-4132	269	23	ligands	ligand	NOUN
gs-4132	269	24	.	.	PUNCT
gs-4132	270	1	unlike	unlike	ADP
gs-4132	270	2	biological	biological	ADJ
gs-4132	270	3	vesicles	vesicle	NOUN
gs-4132	270	4	,	,	PUNCT
gs-4132	270	5	synthetic	synthetic	ADJ
gs-4132	270	6	nanocarriers	nanocarrier	NOUN
gs-4132	270	7	can	can	AUX
gs-4132	270	8	be	be	AUX
gs-4132	270	9	engineered	engineer	VERB
gs-4132	270	10	to	to	PART
gs-4132	270	11	exhibit	exhibit	VERB
gs-4132	270	12	prolonged	prolonged	ADJ
gs-4132	270	13	circulation	circulation	NOUN
gs-4132	270	14	time	time	NOUN
gs-4132	270	15	,	,	PUNCT
gs-4132	270	16	enhanced	enhance	VERB
gs-4132	270	17	stability	stability	NOUN
gs-4132	270	18	under	under	ADP
gs-4132	270	19	physiological	physiological	ADJ
gs-4132	270	20	conditions	condition	NOUN
gs-4132	270	21	,	,	PUNCT
gs-4132	270	22	and	and	CCONJ
gs-4132	270	23	tunable	tunable	ADJ
gs-4132	270	24	release	release	NOUN
gs-4132	270	25	kinetics	kinetic	NOUN
gs-4132	270	26	.	.	PUNCT
gs-4132	271	1	these	these	DET
gs-4132	271	2	characteristics	characteristic	NOUN
gs-4132	271	3	have	have	AUX
gs-4132	271	4	enabled	enable	VERB
gs-4132	271	5	the	the	DET
gs-4132	271	6	translation	translation	NOUN
gs-4132	271	7	of	of	ADP
gs-4132	271	8	several	several	ADJ
gs-4132	271	9	nanoparticle	nanoparticle	NOUN
gs-4132	271	10	-	-	PUNCT
gs-4132	271	11	based	base	VERB
gs-4132	271	12	therapeutics	therapeutic	NOUN
gs-4132	271	13	into	into	ADP
gs-4132	271	14	clinical	clinical	ADJ
gs-4132	271	15	applications	application	NOUN
gs-4132	271	16	,	,	PUNCT
gs-4132	271	17	exemplifying	exemplify	VERB
gs-4132	271	18	the	the	DET
gs-4132	271	19	potential	potential	NOUN
gs-4132	271	20	of	of	ADP
gs-4132	271	21	these	these	DET
gs-4132	271	22	platforms	platform	NOUN
gs-4132	271	23	to	to	PART
gs-4132	271	24	revolutionize	revolutionize	VERB
gs-4132	271	25	drug	drug	NOUN
gs-4132	271	26	delivery	delivery	NOUN
gs-4132	271	27	and	and	CCONJ
gs-4132	271	28	precision	precision	NOUN
gs-4132	271	29	medicine	medicine	NOUN
gs-4132	271	30	.	.	PUNCT
gs-4132	272	1	comparative	comparative	ADJ
gs-4132	272	2	analyses	analysis	NOUN
gs-4132	272	3	of	of	ADP
gs-4132	272	4	exosomes	exosome	NOUN
gs-4132	272	5	and	and	CCONJ
gs-4132	272	6	synthetic	synthetic	ADJ
gs-4132	272	7	nanocarriers	nanocarrier	NOUN
gs-4132	272	8	reveal	reveal	VERB
gs-4132	272	9	a	a	DET
gs-4132	272	10	spectrum	spectrum	NOUN
gs-4132	272	11	of	of	ADP
gs-4132	272	12	advantages	advantage	NOUN
gs-4132	272	13	and	and	CCONJ
gs-4132	272	14	limitations	limitation	NOUN
gs-4132	272	15	that	that	PRON
gs-4132	272	16	must	must	AUX
gs-4132	272	17	be	be	AUX
gs-4132	272	18	considered	consider	VERB
gs-4132	272	19	in	in	ADP
gs-4132	272	20	therapeutic	therapeutic	ADJ
gs-4132	272	21	design	design	NOUN
gs-4132	272	22	.	.	PUNCT
gs-4132	273	1	exosomes	exosome	NOUN
gs-4132	273	2	exhibit	exhibit	VERB
gs-4132	273	3	inherent	inherent	ADJ
gs-4132	273	4	targeting	target	VERB
gs-4132	273	5	capabilities	capability	NOUN
gs-4132	273	6	,	,	PUNCT
gs-4132	273	7	as	as	SCONJ
gs-4132	273	8	their	their	PRON
gs-4132	273	9	surface	surface	NOUN
gs-4132	273	10	proteins	protein	NOUN
gs-4132	273	11	often	often	ADV
gs-4132	273	12	reflect	reflect	VERB
gs-4132	273	13	the	the	DET
gs-4132	273	14	cellular	cellular	ADJ
gs-4132	273	15	origin	origin	NOUN
gs-4132	273	16	and	and	CCONJ
gs-4132	273	17	tissue	tissue	NOUN
gs-4132	273	18	tropism	tropism	NOUN
gs-4132	273	19	of	of	ADP
gs-4132	273	20	the	the	DET
gs-4132	273	21	parent	parent	NOUN
gs-4132	273	22	cells	cell	NOUN
gs-4132	273	23	.	.	PUNCT
gs-4132	274	1	this	this	PRON
gs-4132	274	2	allows	allow	VERB
gs-4132	274	3	exosome	exosome	NOUN
gs-4132	274	4	-	-	PUNCT
gs-4132	274	5	mediated	mediate	VERB
gs-4132	274	6	delivery	delivery	NOUN
gs-4132	274	7	to	to	PART
gs-4132	274	8	achieve	achieve	VERB
gs-4132	274	9	high	high	ADJ
gs-4132	274	10	specificity	specificity	NOUN
gs-4132	274	11	,	,	PUNCT
gs-4132	274	12	particularly	particularly	ADV
gs-4132	274	13	in	in	ADP
gs-4132	274	14	the	the	DET
gs-4132	274	15	context	context	NOUN
gs-4132	274	16	of	of	ADP
gs-4132	274	17	oncology	oncology	NOUN
gs-4132	274	18	and	and	CCONJ
gs-4132	274	19	regenerative	regenerative	ADJ
gs-4132	274	20	medicine	medicine	NOUN
gs-4132	274	21	.	.	PUNCT
gs-4132	275	1	furthermore	furthermore	ADV
gs-4132	275	2	,	,	PUNCT
gs-4132	275	3	exosomes	exosome	NOUN
gs-4132	275	4	are	be	AUX
gs-4132	275	5	capable	capable	ADJ
gs-4132	275	6	of	of	ADP
gs-4132	275	7	evading	evade	VERB
gs-4132	275	8	phagocytic	phagocytic	ADJ
gs-4132	275	9	clearance	clearance	NOUN
gs-4132	275	10	and	and	CCONJ
gs-4132	275	11	bypassing	bypassing	ADJ
gs-4132	275	12	immune	immune	ADJ
gs-4132	275	13	surveillance	surveillance	NOUN
gs-4132	275	14	mechanisms	mechanism	NOUN
gs-4132	275	15	more	more	ADV
gs-4132	275	16	effectively	effectively	ADV
gs-4132	275	17	than	than	ADP
gs-4132	275	18	many	many	ADJ
gs-4132	275	19	synthetic	synthetic	ADJ
gs-4132	275	20	carriers	carrier	NOUN
gs-4132	275	21	.	.	PUNCT
gs-4132	276	1	these	these	DET
gs-4132	276	2	properties	property	NOUN
gs-4132	276	3	are	be	AUX
gs-4132	276	4	largely	largely	ADV
gs-4132	276	5	attributed	attribute	VERB
gs-4132	276	6	to	to	ADP
gs-4132	276	7	the	the	DET
gs-4132	276	8	expression	expression	NOUN
gs-4132	276	9	of	of	ADP
gs-4132	276	10	surface	surface	NOUN
gs-4132	276	11	markers	marker	NOUN
gs-4132	276	12	such	such	ADJ
gs-4132	276	13	as	as	ADP
gs-4132	276	14	cd47	cd47	PROPN
gs-4132	276	15	,	,	PUNCT
gs-4132	276	16	which	which	PRON
gs-4132	276	17	confer	confer	VERB
gs-4132	276	18	a	a	PRON
gs-4132	276	19	“	"	PUNCT
gs-4132	276	20	do	do	AUX
gs-4132	276	21	n’t	not	PART
gs-4132	276	22	eat	eat	VERB
gs-4132	276	23	me	i	PRON
gs-4132	276	24	”	"	PUNCT
gs-4132	276	25	signal	signal	NOUN
gs-4132	276	26	to	to	ADP
gs-4132	276	27	phagocytes	phagocyte	NOUN
gs-4132	276	28	,	,	PUNCT
gs-4132	276	29	reducing	reduce	VERB
gs-4132	276	30	uptake	uptake	NOUN
gs-4132	276	31	by	by	ADP
gs-4132	276	32	the	the	DET
gs-4132	276	33	mononuclear	mononuclear	ADJ
gs-4132	276	34	phagocyte	phagocyte	NOUN
gs-4132	276	35	system	system	NOUN
gs-4132	276	36	.	.	PUNCT
gs-4132	277	1	despite	despite	SCONJ
gs-4132	277	2	these	these	DET
gs-4132	277	3	advantages	advantage	NOUN
gs-4132	277	4	,	,	PUNCT
gs-4132	277	5	exosomes	exosome	NOUN
gs-4132	277	6	face	face	VERB
gs-4132	277	7	several	several	ADJ
gs-4132	277	8	practical	practical	ADJ
gs-4132	277	9	challenges	challenge	NOUN
gs-4132	277	10	.	.	PUNCT
gs-4132	278	1	isolation	isolation	NOUN
gs-4132	278	2	and	and	CCONJ
gs-4132	278	3	purification	purification	NOUN
gs-4132	278	4	methods	method	NOUN
gs-4132	278	5	,	,	PUNCT
gs-4132	278	6	such	such	ADJ
gs-4132	278	7	as	as	ADP
gs-4132	278	8	ultracentrifugation	ultracentrifugation	NOUN
gs-4132	278	9	,	,	PUNCT
gs-4132	278	10	size	size	NOUN
gs-4132	278	11	-	-	PUNCT
gs-4132	278	12	exclusion	exclusion	NOUN
gs-4132	278	13	chromatography	chromatography	NOUN
gs-4132	278	14	,	,	PUNCT
gs-4132	278	15	and	and	CCONJ
gs-4132	278	16	immunoaffinity	immunoaffinity	NOUN
gs-4132	278	17	capture	capture	NOUN
gs-4132	278	18	,	,	PUNCT
gs-4132	278	19	often	often	ADV
gs-4132	278	20	yield	yield	VERB
gs-4132	278	21	heterogeneous	heterogeneous	ADJ
gs-4132	278	22	populations	population	NOUN
gs-4132	278	23	with	with	ADP
gs-4132	278	24	variable	variable	ADJ
gs-4132	278	25	loading	loading	NOUN
gs-4132	278	26	efficiency	efficiency	NOUN
gs-4132	278	27	.	.	PUNCT
gs-4132	279	1	standardization	standardization	NOUN
gs-4132	279	2	of	of	ADP
gs-4132	279	3	exosome	exosome	PROPN
gs-4132	279	4	production	production	NOUN
gs-4132	279	5	remains	remain	VERB
gs-4132	279	6	a	a	DET
gs-4132	279	7	critical	critical	ADJ
gs-4132	279	8	barrier	barrier	NOUN
gs-4132	279	9	to	to	ADP
gs-4132	279	10	clinical	clinical	ADJ
gs-4132	279	11	translation	translation	NOUN
gs-4132	279	12	,	,	PUNCT
gs-4132	279	13	as	as	SCONJ
gs-4132	279	14	batch	batch	NOUN
gs-4132	279	15	-	-	PUNCT
gs-4132	279	16	to	to	ADP
gs-4132	279	17	-	-	PUNCT
gs-4132	279	18	batch	batch	NOUN
gs-4132	279	19	variability	variability	NOUN
gs-4132	279	20	can	can	AUX
gs-4132	279	21	significantly	significantly	ADV
gs-4132	279	22	affect	affect	VERB
gs-4132	279	23	therapeutic	therapeutic	ADJ
gs-4132	279	24	outcomes	outcome	NOUN
gs-4132	279	25	.	.	PUNCT
gs-4132	280	1	moreover	moreover	ADV
gs-4132	280	2	,	,	PUNCT
gs-4132	280	3	the	the	DET
gs-4132	280	4	limited	limited	ADJ
gs-4132	280	5	intrinsic	intrinsic	ADJ
gs-4132	280	6	cargo	cargo	NOUN
gs-4132	280	7	capacity	capacity	NOUN
gs-4132	280	8	of	of	ADP
gs-4132	280	9	exosomes	exosome	NOUN
gs-4132	280	10	constrains	constrain	VERB
gs-4132	280	11	their	their	PRON
gs-4132	280	12	ability	ability	NOUN
gs-4132	280	13	to	to	PART
gs-4132	280	14	deliver	deliver	VERB
gs-4132	280	15	large	large	ADJ
gs-4132	280	16	or	or	CCONJ
gs-4132	280	17	multiple	multiple	ADJ
gs-4132	280	18	therapeutic	therapeutic	ADJ
gs-4132	280	19	agents	agent	NOUN
gs-4132	280	20	.	.	PUNCT
gs-4132	281	1	engineering	engineering	NOUN
gs-4132	281	2	strategies	strategy	NOUN
gs-4132	281	3	,	,	PUNCT
gs-4132	281	4	such	such	ADJ
gs-4132	281	5	as	as	ADP
gs-4132	281	6	electroporation	electroporation	NOUN
gs-4132	281	7	,	,	PUNCT
gs-4132	281	8	sonication	sonication	NOUN
gs-4132	281	9	,	,	PUNCT
gs-4132	281	10	or	or	CCONJ
gs-4132	281	11	chemical	chemical	NOUN
gs-4132	281	12	modification	modification	NOUN
gs-4132	281	13	,	,	PUNCT
gs-4132	281	14	have	have	AUX
gs-4132	281	15	been	be	AUX
gs-4132	281	16	developed	develop	VERB
gs-4132	281	17	to	to	PART
gs-4132	281	18	enhance	enhance	VERB
gs-4132	281	19	loading	loading	NOUN
gs-4132	281	20	efficiency	efficiency	NOUN
gs-4132	281	21	,	,	PUNCT
gs-4132	281	22	yet	yet	CCONJ
gs-4132	281	23	these	these	DET
gs-4132	281	24	approaches	approach	NOUN
gs-4132	281	25	can	can	AUX
gs-4132	281	26	compromise	compromise	VERB
gs-4132	281	27	vesicle	vesicle	NOUN
gs-4132	281	28	integrity	integrity	NOUN
gs-4132	281	29	and	and	CCONJ
gs-4132	281	30	bioactivity	bioactivity	NOUN
gs-4132	281	31	.	.	PUNCT
gs-4132	282	1	synthetic	synthetic	ADJ
gs-4132	282	2	nanocarriers	nanocarrier	NOUN
gs-4132	282	3	,	,	PUNCT
gs-4132	282	4	conversely	conversely	ADV
gs-4132	282	5	,	,	PUNCT
gs-4132	282	6	offer	offer	VERB
gs-4132	282	7	a	a	DET
gs-4132	282	8	high	high	ADJ
gs-4132	282	9	degree	degree	NOUN
gs-4132	282	10	of	of	ADP
gs-4132	282	11	reproducibility	reproducibility	NOUN
gs-4132	282	12	and	and	CCONJ
gs-4132	282	13	scalability	scalability	NOUN
gs-4132	282	14	,	,	PUNCT
gs-4132	282	15	which	which	PRON
gs-4132	282	16	are	be	AUX
gs-4132	282	17	essential	essential	ADJ
gs-4132	282	18	for	for	ADP
gs-4132	282	19	regulatory	regulatory	ADJ
gs-4132	282	20	approval	approval	NOUN
gs-4132	282	21	and	and	CCONJ
gs-4132	282	22	mass	mass	NOUN
gs-4132	282	23	production	production	NOUN
gs-4132	282	24	.	.	PUNCT
gs-4132	283	1	liposomes	liposome	NOUN
gs-4132	283	2	,	,	PUNCT
gs-4132	283	3	for	for	ADP
gs-4132	283	4	instance	instance	NOUN
gs-4132	283	5	,	,	PUNCT
gs-4132	283	6	have	have	VERB
gs-4132	283	7	a	a	DET
gs-4132	283	8	well	well	ADV
gs-4132	283	9	-	-	PUNCT
gs-4132	283	10	established	establish	VERB
gs-4132	283	11	safety	safety	NOUN
gs-4132	283	12	profile	profile	NOUN
gs-4132	283	13	and	and	CCONJ
gs-4132	283	14	can	can	AUX
gs-4132	283	15	encapsulate	encapsulate	VERB
gs-4132	283	16	both	both	CCONJ
gs-4132	283	17	hydrophilic	hydrophilic	ADJ
gs-4132	283	18	and	and	CCONJ
gs-4132	283	19	hydrophobic	hydrophobic	NOUN
gs-4132	283	20	molecules	molecule	NOUN
gs-4132	283	21	,	,	PUNCT
gs-4132	283	22	enabling	enable	VERB
gs-4132	283	23	versatile	versatile	ADJ
gs-4132	283	24	therapeutic	therapeutic	ADJ
gs-4132	283	25	applications	application	NOUN
gs-4132	283	26	.	.	PUNCT
gs-4132	284	1	polymeric	polymeric	ADJ
gs-4132	284	2	nanoparticles	nanoparticle	NOUN
gs-4132	284	3	,	,	PUNCT
gs-4132	284	4	constructed	construct	VERB
gs-4132	284	5	from	from	ADP
gs-4132	284	6	biodegradable	biodegradable	ADJ
gs-4132	284	7	polymers	polymer	NOUN
gs-4132	284	8	such	such	ADJ
gs-4132	284	9	as	as	ADP
gs-4132	284	10	poly(lactic	poly(lactic	PROPN
gs-4132	284	11	-	-	PUNCT
gs-4132	284	12	co	co	NOUN
gs-4132	284	13	-	-	ADJ
gs-4132	284	14	glycolic	glycolic	ADJ
gs-4132	284	15	acid	acid	NOUN
gs-4132	284	16	)	)	PUNCT
gs-4132	284	17	(	(	PUNCT
gs-4132	284	18	plga	plga	NOUN
gs-4132	284	19	)	)	PUNCT
gs-4132	284	20	,	,	PUNCT
gs-4132	284	21	provide	provide	VERB
gs-4132	284	22	controlled	control	VERB
gs-4132	284	23	release	release	NOUN
gs-4132	284	24	capabilities	capability	NOUN
gs-4132	284	25	and	and	CCONJ
gs-4132	284	26	can	can	AUX
gs-4132	284	27	be	be	AUX
gs-4132	284	28	functionalized	functionalize	VERB
gs-4132	284	29	with	with	ADP
gs-4132	284	30	targeting	target	VERB
gs-4132	284	31	moieties	moiety	NOUN
gs-4132	284	32	,	,	PUNCT
gs-4132	284	33	enhancing	enhance	VERB
gs-4132	284	34	tissue	tissue	NOUN
gs-4132	284	35	specificity	specificity	NOUN
gs-4132	284	36	.	.	PUNCT
gs-4132	285	1	dendrimers	dendrimer	NOUN
gs-4132	285	2	,	,	PUNCT
gs-4132	285	3	with	with	ADP
gs-4132	285	4	their	their	PRON
gs-4132	285	5	highly	highly	ADV
gs-4132	285	6	branched	branched	ADJ
gs-4132	285	7	architecture	architecture	NOUN
gs-4132	285	8	,	,	PUNCT
gs-4132	285	9	offer	offer	VERB
gs-4132	285	10	multivalent	multivalent	NOUN
gs-4132	285	11	surface	surface	PROPN
gs-4132	285	12	modification	modification	NOUN
gs-4132	285	13	and	and	CCONJ
gs-4132	285	14	tunable	tunable	ADJ
gs-4132	285	15	drug	drug	NOUN
gs-4132	285	16	loading	loading	NOUN
gs-4132	285	17	,	,	PUNCT
gs-4132	285	18	while	while	SCONJ
gs-4132	285	19	inorganic	inorganic	ADJ
gs-4132	285	20	nanoparticles	nanoparticle	NOUN
gs-4132	285	21	,	,	PUNCT
gs-4132	285	22	including	include	VERB
gs-4132	285	23	gold	gold	NOUN
gs-4132	285	24	and	and	CCONJ
gs-4132	285	25	silica	silica	NOUN
gs-4132	285	26	-	-	PUNCT
gs-4132	285	27	based	base	VERB
gs-4132	285	28	platforms	platform	NOUN
gs-4132	285	29	,	,	PUNCT
gs-4132	285	30	provide	provide	VERB
gs-4132	285	31	unique	unique	ADJ
gs-4132	285	32	optical	optical	ADJ
gs-4132	285	33	and	and	CCONJ
gs-4132	285	34	magnetic	magnetic	ADJ
gs-4132	285	35	properties	property	NOUN
gs-4132	285	36	for	for	ADP
gs-4132	285	37	theranostic	theranostic	ADJ
gs-4132	285	38	applications	application	NOUN
gs-4132	285	39	.	.	PUNCT
gs-4132	286	1	the	the	DET
gs-4132	286	2	primary	primary	ADJ
gs-4132	286	3	limitation	limitation	NOUN
gs-4132	286	4	of	of	ADP
gs-4132	286	5	synthetic	synthetic	ADJ
gs-4132	286	6	systems	system	NOUN
gs-4132	286	7	lies	lie	VERB
gs-4132	286	8	in	in	ADP
gs-4132	286	9	their	their	PRON
gs-4132	286	10	potential	potential	ADJ
gs-4132	286	11	immunogenicity	immunogenicity	NOUN
gs-4132	286	12	,	,	PUNCT
gs-4132	286	13	off	off	ADP
gs-4132	286	14	-	-	PUNCT
gs-4132	286	15	target	target	NOUN
gs-4132	286	16	accumulation	accumulation	NOUN
gs-4132	286	17	,	,	PUNCT
gs-4132	286	18	and	and	CCONJ
gs-4132	286	19	limited	limited	ADJ
gs-4132	286	20	biological	biological	ADJ
gs-4132	286	21	recognition	recognition	NOUN
gs-4132	286	22	,	,	PUNCT
gs-4132	286	23	which	which	PRON
gs-4132	286	24	can	can	AUX
gs-4132	286	25	lead	lead	VERB
gs-4132	286	26	to	to	ADP
gs-4132	286	27	rapid	rapid	ADJ
gs-4132	286	28	clearance	clearance	NOUN
gs-4132	286	29	or	or	CCONJ
gs-4132	286	30	unintended	unintended	ADJ
gs-4132	286	31	toxicity	toxicity	NOUN
gs-4132	286	32	.	.	PUNCT
gs-4132	287	1	surface	surface	NOUN
gs-4132	287	2	modification	modification	NOUN
gs-4132	287	3	strategies	strategy	NOUN
gs-4132	287	4	,	,	PUNCT
gs-4132	287	5	such	such	ADJ
gs-4132	287	6	as	as	ADP
gs-4132	287	7	pegylation	pegylation	NOUN
gs-4132	287	8	,	,	PUNCT
gs-4132	287	9	have	have	AUX
gs-4132	287	10	been	be	AUX
gs-4132	287	11	employed	employ	VERB
gs-4132	287	12	to	to	PART
gs-4132	287	13	mitigate	mitigate	VERB
gs-4132	287	14	these	these	DET
gs-4132	287	15	issues	issue	NOUN
gs-4132	287	16	,	,	PUNCT
gs-4132	287	17	but	but	CCONJ
gs-4132	287	18	these	these	DET
gs-4132	287	19	modifications	modification	NOUN
gs-4132	287	20	can	can	AUX
gs-4132	287	21	also	also	ADV
gs-4132	287	22	impact	impact	VERB
gs-4132	287	23	cellular	cellular	ADJ
gs-4132	287	24	uptake	uptake	NOUN
gs-4132	287	25	and	and	CCONJ
gs-4132	287	26	endosomal	endosomal	ADJ
gs-4132	287	27	escape	escape	NOUN
gs-4132	287	28	,	,	PUNCT
gs-4132	287	29	creating	create	VERB
gs-4132	287	30	a	a	DET
gs-4132	287	31	complex	complex	ADJ
gs-4132	287	32	balance	balance	NOUN
gs-4132	287	33	between	between	ADP
gs-4132	287	34	stability	stability	NOUN
gs-4132	287	35	and	and	CCONJ
gs-4132	287	36	functional	functional	ADJ
gs-4132	287	37	delivery	delivery	NOUN
gs-4132	287	38	.	.	PUNCT
gs-4132	288	1	georgian	georgian	NOUN
gs-4132	288	2	scientists/	scientists/	NUM
gs-4132	288	3	.	.	PUNCT
gs-4132	289	1	7	7	NUM
gs-4132	289	2	n	n	DET
gs-4132	289	3	4	4	NUM
gs-4132	289	4	,	,	PUNCT
gs-4132	289	5	2025	2025	NUM
gs-4132	289	6	19	19	NUM
gs-4132	289	7	the	the	DET
gs-4132	289	8	therapeutic	therapeutic	ADJ
gs-4132	289	9	application	application	NOUN
gs-4132	289	10	of	of	ADP
gs-4132	289	11	exosomes	exosome	NOUN
gs-4132	289	12	extends	extend	VERB
gs-4132	289	13	across	across	ADP
gs-4132	289	14	diverse	diverse	ADJ
gs-4132	289	15	medical	medical	ADJ
gs-4132	289	16	fields	field	NOUN
gs-4132	289	17	,	,	PUNCT
gs-4132	289	18	ranging	range	VERB
gs-4132	289	19	from	from	ADP
gs-4132	289	20	oncology	oncology	NOUN
gs-4132	289	21	to	to	ADP
gs-4132	289	22	neurodegenerative	neurodegenerative	ADJ
gs-4132	289	23	diseases	disease	NOUN
gs-4132	289	24	.	.	PUNCT
gs-4132	290	1	tumor	tumor	NOUN
gs-4132	290	2	-	-	PUNCT
gs-4132	290	3	derived	derive	VERB
gs-4132	290	4	exosomes	exosome	NOUN
gs-4132	290	5	have	have	AUX
gs-4132	290	6	been	be	AUX
gs-4132	290	7	harnessed	harness	VERB
gs-4132	290	8	as	as	ADP
gs-4132	290	9	natural	natural	ADJ
gs-4132	290	10	carriers	carrier	NOUN
gs-4132	290	11	for	for	ADP
gs-4132	290	12	chemotherapeutic	chemotherapeutic	ADJ
gs-4132	290	13	agents	agent	NOUN
gs-4132	290	14	,	,	PUNCT
gs-4132	290	15	leveraging	leverage	VERB
gs-4132	290	16	their	their	PRON
gs-4132	290	17	inherent	inherent	ADJ
gs-4132	290	18	tropism	tropism	NOUN
gs-4132	290	19	to	to	ADP
gs-4132	290	20	tumor	tumor	NOUN
gs-4132	290	21	cells	cell	NOUN
gs-4132	290	22	to	to	PART
gs-4132	290	23	achieve	achieve	VERB
gs-4132	290	24	targeted	target	VERB
gs-4132	290	25	cytotoxicity	cytotoxicity	NOUN
gs-4132	290	26	while	while	SCONJ
gs-4132	290	27	minimizing	minimize	VERB
gs-4132	290	28	systemic	systemic	ADJ
gs-4132	290	29	side	side	NOUN
gs-4132	290	30	effects	effect	NOUN
gs-4132	290	31	.	.	PUNCT
gs-4132	291	1	in	in	ADP
gs-4132	291	2	regenerative	regenerative	ADJ
gs-4132	291	3	medicine	medicine	NOUN
gs-4132	291	4	,	,	PUNCT
gs-4132	291	5	mesenchymal	mesenchymal	NOUN
gs-4132	291	6	stem	stem	NOUN
gs-4132	291	7	cell	cell	NOUN
gs-4132	291	8	-	-	PUNCT
gs-4132	291	9	derived	derive	VERB
gs-4132	291	10	exosomes	exosome	NOUN
gs-4132	291	11	have	have	AUX
gs-4132	291	12	demonstrated	demonstrate	VERB
gs-4132	291	13	immunomodulatory	immunomodulatory	ADJ
gs-4132	291	14	and	and	CCONJ
gs-4132	291	15	tissue	tissue	NOUN
gs-4132	291	16	repair	repair	NOUN
gs-4132	291	17	properties	property	NOUN
gs-4132	291	18	,	,	PUNCT
gs-4132	291	19	promoting	promote	VERB
gs-4132	291	20	angiogenesis	angiogenesis	NOUN
gs-4132	291	21	,	,	PUNCT
gs-4132	291	22	reducing	reduce	VERB
gs-4132	291	23	inflammation	inflammation	NOUN
gs-4132	291	24	,	,	PUNCT
gs-4132	291	25	and	and	CCONJ
gs-4132	291	26	facilitating	facilitate	VERB
gs-4132	291	27	cellular	cellular	ADJ
gs-4132	291	28	proliferation	proliferation	NOUN
gs-4132	291	29	in	in	ADP
gs-4132	291	30	models	model	NOUN
gs-4132	291	31	of	of	ADP
gs-4132	291	32	cardiac	cardiac	ADJ
gs-4132	291	33	injury	injury	NOUN
gs-4132	291	34	,	,	PUNCT
gs-4132	291	35	stroke	stroke	NOUN
gs-4132	291	36	,	,	PUNCT
gs-4132	291	37	and	and	CCONJ
gs-4132	291	38	musculoskeletal	musculoskeletal	ADJ
gs-4132	291	39	damage	damage	NOUN
gs-4132	291	40	.	.	PUNCT
gs-4132	292	1	furthermore	furthermore	ADV
gs-4132	292	2	,	,	PUNCT
gs-4132	292	3	exosomes	exosome	NOUN
gs-4132	292	4	serve	serve	VERB
gs-4132	292	5	as	as	ADP
gs-4132	292	6	platforms	platform	NOUN
gs-4132	292	7	for	for	ADP
gs-4132	292	8	nucleic	nucleic	ADJ
gs-4132	292	9	acid	acid	NOUN
gs-4132	292	10	delivery	delivery	NOUN
gs-4132	292	11	,	,	PUNCT
gs-4132	292	12	including	include	VERB
gs-4132	292	13	small	small	ADJ
gs-4132	292	14	interfering	interfere	VERB
gs-4132	292	15	rna	rna	NOUN
gs-4132	292	16	(	(	PUNCT
gs-4132	292	17	sirna	sirna	PROPN
gs-4132	292	18	)	)	PUNCT
gs-4132	292	19	and	and	CCONJ
gs-4132	292	20	microrna	microrna	PROPN
gs-4132	292	21	(	(	PUNCT
gs-4132	292	22	mirna	mirna	PROPN
gs-4132	292	23	)	)	PUNCT
gs-4132	292	24	,	,	PUNCT
gs-4132	292	25	providing	provide	VERB
gs-4132	292	26	opportunities	opportunity	NOUN
gs-4132	292	27	for	for	ADP
gs-4132	292	28	gene	gene	NOUN
gs-4132	292	29	modulation	modulation	NOUN
gs-4132	292	30	therapies	therapy	NOUN
gs-4132	292	31	that	that	PRON
gs-4132	292	32	are	be	AUX
gs-4132	292	33	otherwise	otherwise	ADV
gs-4132	292	34	challenging	challenging	ADJ
gs-4132	292	35	to	to	PART
gs-4132	292	36	achieve	achieve	VERB
gs-4132	292	37	due	due	ADJ
gs-4132	292	38	to	to	ADP
gs-4132	292	39	nucleic	nucleic	ADJ
gs-4132	292	40	acid	acid	NOUN
gs-4132	292	41	instability	instability	NOUN
gs-4132	292	42	and	and	CCONJ
gs-4132	292	43	poor	poor	ADJ
gs-4132	292	44	cellular	cellular	ADJ
gs-4132	292	45	uptake	uptake	NOUN
gs-4132	292	46	.	.	PUNCT
gs-4132	293	1	synthetic	synthetic	ADJ
gs-4132	293	2	nanocarriers	nanocarrier	NOUN
gs-4132	293	3	have	have	AUX
gs-4132	293	4	similarly	similarly	ADV
gs-4132	293	5	been	be	AUX
gs-4132	293	6	applied	apply	VERB
gs-4132	293	7	across	across	ADP
gs-4132	293	8	a	a	DET
gs-4132	293	9	broad	broad	ADJ
gs-4132	293	10	therapeutic	therapeutic	ADJ
gs-4132	293	11	spectrum	spectrum	NOUN
gs-4132	293	12	.	.	PUNCT
gs-4132	294	1	liposomal	liposomal	ADJ
gs-4132	294	2	formulations	formulation	NOUN
gs-4132	294	3	of	of	ADP
gs-4132	294	4	chemotherapeutics	chemotherapeutic	NOUN
gs-4132	294	5	,	,	PUNCT
gs-4132	294	6	such	such	ADJ
gs-4132	294	7	as	as	ADP
gs-4132	294	8	doxorubicin	doxorubicin	PROPN
gs-4132	294	9	and	and	CCONJ
gs-4132	294	10	paclitaxel	paclitaxel	PROPN
gs-4132	294	11	,	,	PUNCT
gs-4132	294	12	have	have	AUX
gs-4132	294	13	achieved	achieve	VERB
gs-4132	294	14	enhanced	enhanced	ADJ
gs-4132	294	15	bioavailability	bioavailability	NOUN
gs-4132	294	16	and	and	CCONJ
gs-4132	294	17	reduced	reduced	ADJ
gs-4132	294	18	cardiotoxicity	cardiotoxicity	NOUN
gs-4132	294	19	,	,	PUNCT
gs-4132	294	20	illustrating	illustrate	VERB
gs-4132	294	21	the	the	DET
gs-4132	294	22	clinical	clinical	ADJ
gs-4132	294	23	potential	potential	NOUN
gs-4132	294	24	of	of	ADP
gs-4132	294	25	engineered	engineer	VERB
gs-4132	294	26	nanoparticles	nanoparticle	NOUN
gs-4132	294	27	.	.	PUNCT
gs-4132	295	1	polymeric	polymeric	ADJ
gs-4132	295	2	nanoparticles	nanoparticle	NOUN
gs-4132	295	3	have	have	AUX
gs-4132	295	4	been	be	AUX
gs-4132	295	5	leveraged	leverage	VERB
gs-4132	295	6	to	to	PART
gs-4132	295	7	deliver	deliver	VERB
gs-4132	295	8	geneediting	geneedite	VERB
gs-4132	295	9	tools	tool	NOUN
gs-4132	295	10	such	such	ADJ
gs-4132	295	11	as	as	ADP
gs-4132	295	12	crispr	crispr	ADJ
gs-4132	295	13	-	-	PUNCT
gs-4132	295	14	cas9	cas9	NOUN
gs-4132	295	15	components	component	NOUN
gs-4132	295	16	,	,	PUNCT
gs-4132	295	17	enabling	enable	VERB
gs-4132	295	18	precise	precise	ADJ
gs-4132	295	19	genome	genome	NOUN
gs-4132	295	20	modification	modification	NOUN
gs-4132	295	21	in	in	ADP
gs-4132	295	22	target	target	NOUN
gs-4132	295	23	tissues	tissue	NOUN
gs-4132	295	24	.	.	PUNCT
gs-4132	296	1	the	the	DET
gs-4132	296	2	modularity	modularity	NOUN
gs-4132	296	3	of	of	ADP
gs-4132	296	4	synthetic	synthetic	ADJ
gs-4132	296	5	carriers	carrier	NOUN
gs-4132	296	6	facilitates	facilitate	VERB
gs-4132	296	7	combination	combination	NOUN
gs-4132	296	8	therapy	therapy	NOUN
gs-4132	296	9	,	,	PUNCT
gs-4132	296	10	where	where	SCONJ
gs-4132	296	11	multiple	multiple	ADJ
gs-4132	296	12	drugs	drug	NOUN
gs-4132	296	13	or	or	CCONJ
gs-4132	296	14	therapeutic	therapeutic	ADJ
gs-4132	296	15	agents	agent	NOUN
gs-4132	296	16	can	can	AUX
gs-4132	296	17	be	be	AUX
gs-4132	296	18	co	co	VERB
gs-4132	296	19	-	-	VERB
gs-4132	296	20	encapsulated	encapsulate	VERB
gs-4132	296	21	to	to	PART
gs-4132	296	22	achieve	achieve	VERB
gs-4132	296	23	synergistic	synergistic	ADJ
gs-4132	296	24	effects	effect	NOUN
gs-4132	296	25	.	.	PUNCT
gs-4132	297	1	in	in	ADP
gs-4132	297	2	addition	addition	NOUN
gs-4132	297	3	,	,	PUNCT
gs-4132	297	4	inorganic	inorganic	ADJ
gs-4132	297	5	nanoparticles	nanoparticle	NOUN
gs-4132	297	6	allow	allow	VERB
gs-4132	297	7	for	for	ADP
gs-4132	297	8	integration	integration	NOUN
gs-4132	297	9	with	with	ADP
gs-4132	297	10	imaging	imaging	NOUN
gs-4132	297	11	modalities	modality	NOUN
gs-4132	297	12	,	,	PUNCT
gs-4132	297	13	enabling	enable	VERB
gs-4132	297	14	realtime	realtime	NOUN
gs-4132	297	15	tracking	tracking	NOUN
gs-4132	297	16	of	of	ADP
gs-4132	297	17	drug	drug	NOUN
gs-4132	297	18	distribution	distribution	NOUN
gs-4132	297	19	,	,	PUNCT
gs-4132	297	20	pharmacokinetics	pharmacokinetic	NOUN
gs-4132	297	21	,	,	PUNCT
gs-4132	297	22	and	and	CCONJ
gs-4132	297	23	therapeutic	therapeutic	ADJ
gs-4132	297	24	efficacy	efficacy	NOUN
gs-4132	297	25	,	,	PUNCT
gs-4132	297	26	thereby	thereby	ADV
gs-4132	297	27	supporting	support	VERB
gs-4132	297	28	the	the	DET
gs-4132	297	29	emerging	emerge	VERB
gs-4132	297	30	field	field	NOUN
gs-4132	297	31	of	of	ADP
gs-4132	297	32	theranostics	theranostic	NOUN
gs-4132	297	33	.	.	PUNCT
gs-4132	298	1	a	a	DET
gs-4132	298	2	crucial	crucial	ADJ
gs-4132	298	3	point	point	NOUN
gs-4132	298	4	of	of	ADP
gs-4132	298	5	comparison	comparison	NOUN
gs-4132	298	6	between	between	ADP
gs-4132	298	7	biological	biological	ADJ
gs-4132	298	8	and	and	CCONJ
gs-4132	298	9	synthetic	synthetic	ADJ
gs-4132	298	10	nanocarriers	nanocarrier	NOUN
gs-4132	298	11	is	be	AUX
gs-4132	298	12	the	the	DET
gs-4132	298	13	mechanism	mechanism	NOUN
gs-4132	298	14	of	of	ADP
gs-4132	298	15	cellular	cellular	ADJ
gs-4132	298	16	internalization	internalization	NOUN
gs-4132	298	17	and	and	CCONJ
gs-4132	298	18	intracellular	intracellular	ADJ
gs-4132	298	19	trafficking	trafficking	NOUN
gs-4132	298	20	.	.	PUNCT
gs-4132	299	1	exosomes	exosome	NOUN
gs-4132	299	2	utilize	utilize	VERB
gs-4132	299	3	receptor	receptor	NOUN
gs-4132	299	4	-	-	PUNCT
gs-4132	299	5	mediated	mediate	VERB
gs-4132	299	6	endocytosis	endocytosis	NOUN
gs-4132	299	7	,	,	PUNCT
gs-4132	299	8	membrane	membrane	NOUN
gs-4132	299	9	fusion	fusion	NOUN
gs-4132	299	10	,	,	PUNCT
gs-4132	299	11	and	and	CCONJ
gs-4132	299	12	phagocytosis	phagocytosis	VERB
gs-4132	299	13	to	to	PART
gs-4132	299	14	deliver	deliver	VERB
gs-4132	299	15	cargo	cargo	NOUN
gs-4132	299	16	,	,	PUNCT
gs-4132	299	17	often	often	ADV
gs-4132	299	18	exploiting	exploit	VERB
gs-4132	299	19	natural	natural	ADJ
gs-4132	299	20	signaling	signal	VERB
gs-4132	299	21	pathways	pathway	NOUN
gs-4132	299	22	for	for	ADP
gs-4132	299	23	selective	selective	ADJ
gs-4132	299	24	uptake	uptake	NOUN
gs-4132	299	25	.	.	PUNCT
gs-4132	300	1	this	this	DET
gs-4132	300	2	mechanism	mechanism	NOUN
gs-4132	300	3	not	not	PART
gs-4132	300	4	only	only	ADV
gs-4132	300	5	enhances	enhance	VERB
gs-4132	300	6	specificity	specificity	NOUN
gs-4132	300	7	but	but	CCONJ
gs-4132	300	8	also	also	ADV
gs-4132	300	9	allows	allow	VERB
gs-4132	300	10	for	for	ADP
gs-4132	300	11	bypassing	bypass	VERB
gs-4132	300	12	lysosomal	lysosomal	ADJ
gs-4132	300	13	degradation	degradation	NOUN
gs-4132	300	14	,	,	PUNCT
gs-4132	300	15	preserving	preserve	VERB
gs-4132	300	16	the	the	DET
gs-4132	300	17	functional	functional	ADJ
gs-4132	300	18	integrity	integrity	NOUN
gs-4132	300	19	of	of	ADP
gs-4132	300	20	delivered	deliver	VERB
gs-4132	300	21	biomolecules	biomolecule	NOUN
gs-4132	300	22	.	.	PUNCT
gs-4132	301	1	synthetic	synthetic	ADJ
gs-4132	301	2	nanocarriers	nanocarrier	NOUN
gs-4132	301	3	,	,	PUNCT
gs-4132	301	4	on	on	ADP
gs-4132	301	5	the	the	DET
gs-4132	301	6	other	other	ADJ
gs-4132	301	7	hand	hand	NOUN
gs-4132	301	8	,	,	PUNCT
gs-4132	301	9	primarily	primarily	ADV
gs-4132	301	10	rely	rely	VERB
gs-4132	301	11	on	on	ADP
gs-4132	301	12	endocytic	endocytic	ADJ
gs-4132	301	13	pathways	pathway	NOUN
gs-4132	301	14	,	,	PUNCT
gs-4132	301	15	including	include	VERB
gs-4132	301	16	clathrinand	clathrinand	PROPN
gs-4132	301	17	caveolin	caveolin	NOUN
gs-4132	301	18	-	-	PUNCT
gs-4132	301	19	mediated	mediate	VERB
gs-4132	301	20	endocytosis	endocytosis	NOUN
gs-4132	301	21	,	,	PUNCT
gs-4132	301	22	macropinocytosis	macropinocytosis	NOUN
gs-4132	301	23	,	,	PUNCT
gs-4132	301	24	and	and	CCONJ
gs-4132	301	25	passive	passive	ADJ
gs-4132	301	26	diffusion	diffusion	NOUN
gs-4132	301	27	,	,	PUNCT
gs-4132	301	28	which	which	PRON
gs-4132	301	29	can	can	AUX
gs-4132	301	30	result	result	VERB
gs-4132	301	31	in	in	ADP
gs-4132	301	32	variable	variable	ADJ
gs-4132	301	33	intracellular	intracellular	ADJ
gs-4132	301	34	fate	fate	NOUN
gs-4132	301	35	and	and	CCONJ
gs-4132	301	36	potential	potential	ADJ
gs-4132	301	37	degradation	degradation	NOUN
gs-4132	301	38	of	of	ADP
gs-4132	301	39	the	the	DET
gs-4132	301	40	therapeutic	therapeutic	ADJ
gs-4132	301	41	payload	payload	NOUN
gs-4132	301	42	.	.	PUNCT
gs-4132	302	1	consequently	consequently	ADV
gs-4132	302	2	,	,	PUNCT
gs-4132	302	3	strategies	strategy	NOUN
gs-4132	302	4	to	to	PART
gs-4132	302	5	enhance	enhance	VERB
gs-4132	302	6	endosomal	endosomal	ADJ
gs-4132	302	7	escape	escape	NOUN
gs-4132	302	8	,	,	PUNCT
gs-4132	302	9	such	such	ADJ
gs-4132	302	10	as	as	ADP
gs-4132	302	11	phsensitive	phsensitive	ADJ
gs-4132	302	12	polymers	polymer	NOUN
gs-4132	302	13	or	or	CCONJ
gs-4132	302	14	membrane	membrane	NOUN
gs-4132	302	15	-	-	PUNCT
gs-4132	302	16	disruptive	disruptive	ADJ
gs-4132	302	17	peptides	peptide	NOUN
gs-4132	302	18	,	,	PUNCT
gs-4132	302	19	have	have	AUX
gs-4132	302	20	become	become	VERB
gs-4132	302	21	integral	integral	ADJ
gs-4132	302	22	to	to	ADP
gs-4132	302	23	the	the	DET
gs-4132	302	24	design	design	NOUN
gs-4132	302	25	of	of	ADP
gs-4132	302	26	effective	effective	ADJ
gs-4132	302	27	synthetic	synthetic	ADJ
gs-4132	302	28	nanoparticles	nanoparticle	NOUN
gs-4132	302	29	.	.	PUNCT
gs-4132	303	1	safety	safety	NOUN
gs-4132	303	2	and	and	CCONJ
gs-4132	303	3	immunogenicity	immunogenicity	NOUN
gs-4132	303	4	considerations	consideration	NOUN
gs-4132	303	5	further	far	ADV
gs-4132	303	6	differentiate	differentiate	VERB
gs-4132	303	7	exosomes	exosome	NOUN
gs-4132	303	8	from	from	ADP
gs-4132	303	9	synthetic	synthetic	ADJ
gs-4132	303	10	carriers	carrier	NOUN
gs-4132	303	11	.	.	PUNCT
gs-4132	304	1	while	while	SCONJ
gs-4132	304	2	exosomes	exosome	NOUN
gs-4132	304	3	generally	generally	ADV
gs-4132	304	4	exhibit	exhibit	VERB
gs-4132	304	5	low	low	ADJ
gs-4132	304	6	immunogenicity	immunogenicity	NOUN
gs-4132	304	7	due	due	ADP
gs-4132	304	8	to	to	ADP
gs-4132	304	9	their	their	PRON
gs-4132	304	10	endogenous	endogenous	ADJ
gs-4132	304	11	origin	origin	NOUN
gs-4132	304	12	,	,	PUNCT
gs-4132	304	13	there	there	PRON
gs-4132	304	14	is	be	VERB
gs-4132	304	15	the	the	DET
gs-4132	304	16	potential	potential	NOUN
gs-4132	304	17	for	for	ADP
gs-4132	304	18	pro	pro	ADJ
gs-4132	304	19	-	-	ADJ
gs-4132	304	20	tumorigenic	tumorigenic	ADJ
gs-4132	304	21	or	or	CCONJ
gs-4132	304	22	pro	pro	ADJ
gs-4132	304	23	-	-	ADJ
gs-4132	304	24	inflammatory	inflammatory	ADJ
gs-4132	304	25	effects	effect	NOUN
gs-4132	304	26	depending	depend	VERB
gs-4132	304	27	on	on	ADP
gs-4132	304	28	the	the	DET
gs-4132	304	29	cellular	cellular	ADJ
gs-4132	304	30	source	source	NOUN
gs-4132	304	31	.	.	PUNCT
gs-4132	305	1	tumor	tumor	NOUN
gs-4132	305	2	-	-	PUNCT
gs-4132	305	3	derived	derive	VERB
gs-4132	305	4	exosomes	exosome	NOUN
gs-4132	305	5	,	,	PUNCT
gs-4132	305	6	for	for	ADP
gs-4132	305	7	example	example	NOUN
gs-4132	305	8	,	,	PUNCT
gs-4132	305	9	may	may	AUX
gs-4132	305	10	carry	carry	VERB
gs-4132	305	11	oncogenic	oncogenic	ADJ
gs-4132	305	12	proteins	protein	NOUN
gs-4132	305	13	or	or	CCONJ
gs-4132	305	14	nucleic	nucleic	ADJ
gs-4132	305	15	acids	acid	NOUN
gs-4132	305	16	that	that	PRON
gs-4132	305	17	could	could	AUX
gs-4132	305	18	inadvertently	inadvertently	ADV
gs-4132	305	19	promote	promote	VERB
gs-4132	305	20	metastasis	metastasis	PRON
gs-4132	305	21	if	if	SCONJ
gs-4132	305	22	not	not	PART
gs-4132	305	23	carefully	carefully	ADV
gs-4132	305	24	characterized	characterize	VERB
gs-4132	305	25	.	.	PUNCT
gs-4132	306	1	synthetic	synthetic	ADJ
gs-4132	306	2	nanoparticles	nanoparticle	NOUN
gs-4132	306	3	are	be	AUX
gs-4132	306	4	more	more	ADV
gs-4132	306	5	prone	prone	ADJ
gs-4132	306	6	to	to	ADP
gs-4132	306	7	eliciting	elicit	VERB
gs-4132	306	8	immune	immune	ADJ
gs-4132	306	9	responses	response	NOUN
gs-4132	306	10	,	,	PUNCT
gs-4132	306	11	including	include	VERB
gs-4132	306	12	complement	complement	NOUN
gs-4132	306	13	activation	activation	NOUN
gs-4132	306	14	,	,	PUNCT
gs-4132	306	15	cytokine	cytokine	NOUN
gs-4132	306	16	release	release	NOUN
gs-4132	306	17	,	,	PUNCT
gs-4132	306	18	and	and	CCONJ
gs-4132	306	19	hypersensitivity	hypersensitivity	NOUN
gs-4132	306	20	reactions	reaction	NOUN
gs-4132	306	21	.	.	PUNCT
gs-4132	307	1	surface	surface	NOUN
gs-4132	307	2	modifications	modification	NOUN
gs-4132	307	3	and	and	CCONJ
gs-4132	307	4	careful	careful	ADJ
gs-4132	307	5	selection	selection	NOUN
gs-4132	307	6	of	of	ADP
gs-4132	307	7	materials	material	NOUN
gs-4132	307	8	are	be	AUX
gs-4132	307	9	essential	essential	ADJ
gs-4132	307	10	to	to	PART
gs-4132	307	11	minimize	minimize	VERB
gs-4132	307	12	these	these	DET
gs-4132	307	13	risks	risk	NOUN
gs-4132	307	14	,	,	PUNCT
gs-4132	307	15	yet	yet	CCONJ
gs-4132	307	16	the	the	DET
gs-4132	307	17	long	long	ADJ
gs-4132	307	18	-	-	PUNCT
gs-4132	307	19	term	term	NOUN
gs-4132	307	20	immunological	immunological	ADJ
gs-4132	307	21	consequences	consequence	NOUN
gs-4132	307	22	of	of	ADP
gs-4132	307	23	repeated	repeat	VERB
gs-4132	307	24	administration	administration	NOUN
gs-4132	307	25	remain	remain	VERB
gs-4132	307	26	an	an	DET
gs-4132	307	27	area	area	NOUN
gs-4132	307	28	of	of	ADP
gs-4132	307	29	active	active	ADJ
gs-4132	307	30	investigation	investigation	NOUN
gs-4132	307	31	.	.	PUNCT
gs-4132	308	1	emerging	emerge	VERB
gs-4132	308	2	strategies	strategy	NOUN
gs-4132	308	3	seek	seek	VERB
gs-4132	308	4	to	to	PART
gs-4132	308	5	integrate	integrate	VERB
gs-4132	308	6	the	the	DET
gs-4132	308	7	advantages	advantage	NOUN
gs-4132	308	8	of	of	ADP
gs-4132	308	9	both	both	CCONJ
gs-4132	308	10	biological	biological	ADJ
gs-4132	308	11	and	and	CCONJ
gs-4132	308	12	synthetic	synthetic	ADJ
gs-4132	308	13	systems	system	NOUN
gs-4132	308	14	,	,	PUNCT
gs-4132	308	15	giving	give	VERB
gs-4132	308	16	rise	rise	NOUN
gs-4132	308	17	to	to	ADP
gs-4132	308	18	hybrid	hybrid	ADJ
gs-4132	308	19	nanocarriers	nanocarrier	NOUN
gs-4132	308	20	.	.	PUNCT
gs-4132	309	1	these	these	DET
gs-4132	309	2	hybrid	hybrid	ADJ
gs-4132	309	3	platforms	platform	NOUN
gs-4132	309	4	combine	combine	VERB
gs-4132	309	5	the	the	DET
gs-4132	309	6	biocompatibility	biocompatibility	NOUN
gs-4132	309	7	and	and	CCONJ
gs-4132	309	8	targeting	target	VERB
gs-4132	309	9	capabilities	capability	NOUN
gs-4132	309	10	of	of	ADP
gs-4132	309	11	exosomes	exosome	NOUN
gs-4132	309	12	with	with	ADP
gs-4132	309	13	the	the	DET
gs-4132	309	14	structural	structural	ADJ
gs-4132	309	15	tunability	tunability	NOUN
gs-4132	309	16	and	and	CCONJ
gs-4132	309	17	georgian	georgian	NOUN
gs-4132	309	18	scientists/	scientists/	NUM
gs-4132	309	19	.	.	PUNCT
gs-4132	310	1	7	7	NUM
gs-4132	310	2	n	n	DET
gs-4132	310	3	4	4	NUM
gs-4132	310	4	,	,	PUNCT
gs-4132	310	5	2025	2025	NUM
gs-4132	310	6	20	20	NUM
gs-4132	310	7	payload	payload	NOUN
gs-4132	310	8	versatility	versatility	NOUN
gs-4132	310	9	of	of	ADP
gs-4132	310	10	synthetic	synthetic	ADJ
gs-4132	310	11	nanoparticles	nanoparticle	NOUN
gs-4132	310	12	.	.	PUNCT
gs-4132	311	1	techniques	technique	NOUN
gs-4132	311	2	such	such	ADJ
gs-4132	311	3	as	as	ADP
gs-4132	311	4	exosome	exosome	ADJ
gs-4132	311	5	-	-	PUNCT
gs-4132	311	6	mimetic	mimetic	ADJ
gs-4132	311	7	vesicles	vesicle	NOUN
gs-4132	311	8	,	,	PUNCT
gs-4132	311	9	where	where	SCONJ
gs-4132	311	10	cellular	cellular	ADJ
gs-4132	311	11	membranes	membrane	NOUN
gs-4132	311	12	are	be	AUX
gs-4132	311	13	fused	fuse	VERB
gs-4132	311	14	with	with	ADP
gs-4132	311	15	synthetic	synthetic	ADJ
gs-4132	311	16	cores	core	NOUN
gs-4132	311	17	,	,	PUNCT
gs-4132	311	18	have	have	AUX
gs-4132	311	19	demonstrated	demonstrate	VERB
gs-4132	311	20	enhanced	enhanced	ADJ
gs-4132	311	21	drug	drug	NOUN
gs-4132	311	22	loading	loading	NOUN
gs-4132	311	23	and	and	CCONJ
gs-4132	311	24	controlled	control	VERB
gs-4132	311	25	release	release	NOUN
gs-4132	311	26	while	while	SCONJ
gs-4132	311	27	retaining	retain	VERB
gs-4132	311	28	natural	natural	ADJ
gs-4132	311	29	targeting	targeting	NOUN
gs-4132	311	30	properties	property	NOUN
gs-4132	311	31	.	.	PUNCT
gs-4132	312	1	similarly	similarly	ADV
gs-4132	312	2	,	,	PUNCT
gs-4132	312	3	functionalization	functionalization	NOUN
gs-4132	312	4	of	of	ADP
gs-4132	312	5	exosomes	exosome	NOUN
gs-4132	312	6	with	with	ADP
gs-4132	312	7	polymeric	polymeric	ADJ
gs-4132	312	8	or	or	CCONJ
gs-4132	312	9	lipid	lipid	NOUN
gs-4132	312	10	coatings	coating	NOUN
gs-4132	312	11	can	can	AUX
gs-4132	312	12	improve	improve	VERB
gs-4132	312	13	stability	stability	NOUN
gs-4132	312	14	,	,	PUNCT
gs-4132	312	15	extend	extend	VERB
gs-4132	312	16	circulation	circulation	NOUN
gs-4132	312	17	time	time	NOUN
gs-4132	312	18	,	,	PUNCT
gs-4132	312	19	and	and	CCONJ
gs-4132	312	20	facilitate	facilitate	VERB
gs-4132	312	21	precise	precise	ADJ
gs-4132	312	22	therapeutic	therapeutic	ADJ
gs-4132	312	23	delivery	delivery	NOUN
gs-4132	312	24	.	.	PUNCT
gs-4132	313	1	these	these	DET
gs-4132	313	2	hybrid	hybrid	ADJ
gs-4132	313	3	approaches	approach	NOUN
gs-4132	313	4	represent	represent	VERB
gs-4132	313	5	a	a	DET
gs-4132	313	6	promising	promising	ADJ
gs-4132	313	7	convergence	convergence	NOUN
gs-4132	313	8	of	of	ADP
gs-4132	313	9	natural	natural	ADJ
gs-4132	313	10	and	and	CCONJ
gs-4132	313	11	engineered	engineered	ADJ
gs-4132	313	12	strategies	strategy	NOUN
gs-4132	313	13	,	,	PUNCT
gs-4132	313	14	aiming	aim	VERB
gs-4132	313	15	to	to	PART
gs-4132	313	16	overcome	overcome	VERB
gs-4132	313	17	the	the	DET
gs-4132	313	18	limitations	limitation	NOUN
gs-4132	313	19	inherent	inherent	ADJ
gs-4132	313	20	to	to	ADP
gs-4132	313	21	each	each	DET
gs-4132	313	22	individual	individual	ADJ
gs-4132	313	23	system	system	NOUN
gs-4132	313	24	.	.	PUNCT
gs-4132	314	1	analytical	analytical	ADJ
gs-4132	314	2	and	and	CCONJ
gs-4132	314	3	characterization	characterization	NOUN
gs-4132	314	4	methods	method	NOUN
gs-4132	314	5	have	have	AUX
gs-4132	314	6	played	play	VERB
gs-4132	314	7	a	a	DET
gs-4132	314	8	pivotal	pivotal	ADJ
gs-4132	314	9	role	role	NOUN
gs-4132	314	10	in	in	ADP
gs-4132	314	11	advancing	advance	VERB
gs-4132	314	12	the	the	DET
gs-4132	314	13	understanding	understanding	NOUN
gs-4132	314	14	and	and	CCONJ
gs-4132	314	15	application	application	NOUN
gs-4132	314	16	of	of	ADP
gs-4132	314	17	exosomes	exosome	NOUN
gs-4132	314	18	and	and	CCONJ
gs-4132	314	19	synthetic	synthetic	ADJ
gs-4132	314	20	nanocarriers	nanocarrier	NOUN
gs-4132	314	21	.	.	PUNCT
gs-4132	315	1	techniques	technique	NOUN
gs-4132	315	2	such	such	ADJ
gs-4132	315	3	as	as	ADP
gs-4132	315	4	nanoparticle	nanoparticle	NOUN
gs-4132	315	5	tracking	track	VERB
gs-4132	315	6	analysis	analysis	NOUN
gs-4132	315	7	,	,	PUNCT
gs-4132	315	8	dynamic	dynamic	ADJ
gs-4132	315	9	light	light	NOUN
gs-4132	315	10	scattering	scattering	NOUN
gs-4132	315	11	,	,	PUNCT
gs-4132	315	12	electron	electron	NOUN
gs-4132	315	13	microscopy	microscopy	NOUN
gs-4132	315	14	,	,	PUNCT
gs-4132	315	15	and	and	CCONJ
gs-4132	315	16	mass	mass	ADJ
gs-4132	315	17	spectrometry	spectrometry	NOUN
gs-4132	315	18	enable	enable	VERB
gs-4132	315	19	detailed	detailed	ADJ
gs-4132	315	20	evaluation	evaluation	NOUN
gs-4132	315	21	of	of	ADP
gs-4132	315	22	particle	particle	NOUN
gs-4132	315	23	size	size	NOUN
gs-4132	315	24	,	,	PUNCT
gs-4132	315	25	surface	surface	NOUN
gs-4132	315	26	properties	property	NOUN
gs-4132	315	27	,	,	PUNCT
gs-4132	315	28	cargo	cargo	NOUN
gs-4132	315	29	content	content	NOUN
gs-4132	315	30	,	,	PUNCT
gs-4132	315	31	and	and	CCONJ
gs-4132	315	32	purity	purity	NOUN
gs-4132	315	33	.	.	PUNCT
gs-4132	316	1	in	in	ADP
gs-4132	316	2	addition	addition	NOUN
gs-4132	316	3	,	,	PUNCT
gs-4132	316	4	advanced	advanced	ADJ
gs-4132	316	5	omics	omic	NOUN
gs-4132	316	6	technologies	technology	NOUN
gs-4132	316	7	,	,	PUNCT
gs-4132	316	8	including	include	VERB
gs-4132	316	9	proteomics	proteomic	NOUN
gs-4132	316	10	and	and	CCONJ
gs-4132	316	11	transcriptomics	transcriptomic	NOUN
gs-4132	316	12	,	,	PUNCT
gs-4132	316	13	allow	allow	VERB
gs-4132	316	14	for	for	ADP
gs-4132	316	15	comprehensive	comprehensive	ADJ
gs-4132	316	16	profiling	profiling	NOUN
gs-4132	316	17	of	of	ADP
gs-4132	316	18	exosomal	exosomal	ADJ
gs-4132	316	19	cargo	cargo	NOUN
gs-4132	316	20	and	and	CCONJ
gs-4132	316	21	functional	functional	ADJ
gs-4132	316	22	assessment	assessment	NOUN
gs-4132	316	23	of	of	ADP
gs-4132	316	24	therapeutic	therapeutic	ADJ
gs-4132	316	25	potential	potential	NOUN
gs-4132	316	26	.	.	PUNCT
gs-4132	317	1	for	for	ADP
gs-4132	317	2	synthetic	synthetic	ADJ
gs-4132	317	3	nanoparticles	nanoparticle	NOUN
gs-4132	317	4	,	,	PUNCT
gs-4132	317	5	high	high	ADJ
gs-4132	317	6	-	-	PUNCT
gs-4132	317	7	resolution	resolution	NOUN
gs-4132	317	8	imaging	imaging	NOUN
gs-4132	317	9	,	,	PUNCT
gs-4132	317	10	surface	surface	NOUN
gs-4132	317	11	plasmon	plasmon	ADJ
gs-4132	317	12	resonance	resonance	NOUN
gs-4132	317	13	,	,	PUNCT
gs-4132	317	14	and	and	CCONJ
gs-4132	317	15	nuclear	nuclear	ADJ
gs-4132	317	16	magnetic	magnetic	ADJ
gs-4132	317	17	resonance	resonance	NOUN
gs-4132	317	18	spectroscopy	spectroscopy	NOUN
gs-4132	317	19	provide	provide	VERB
gs-4132	317	20	insights	insight	NOUN
gs-4132	317	21	into	into	ADP
gs-4132	317	22	structural	structural	ADJ
gs-4132	317	23	integrity	integrity	NOUN
gs-4132	317	24	,	,	PUNCT
gs-4132	317	25	ligand	ligand	NOUN
gs-4132	317	26	binding	binding	NOUN
gs-4132	317	27	,	,	PUNCT
gs-4132	317	28	and	and	CCONJ
gs-4132	317	29	physicochemical	physicochemical	ADJ
gs-4132	317	30	stability	stability	NOUN
gs-4132	317	31	.	.	PUNCT
gs-4132	318	1	standardization	standardization	NOUN
gs-4132	318	2	of	of	ADP
gs-4132	318	3	these	these	DET
gs-4132	318	4	characterization	characterization	NOUN
gs-4132	318	5	protocols	protocol	NOUN
gs-4132	318	6	is	be	AUX
gs-4132	318	7	essential	essential	ADJ
gs-4132	318	8	for	for	ADP
gs-4132	318	9	reproducibility	reproducibility	NOUN
gs-4132	318	10	,	,	PUNCT
gs-4132	318	11	regulatory	regulatory	ADJ
gs-4132	318	12	compliance	compliance	NOUN
gs-4132	318	13	,	,	PUNCT
gs-4132	318	14	and	and	CCONJ
gs-4132	318	15	successful	successful	ADJ
gs-4132	318	16	translation	translation	NOUN
gs-4132	318	17	into	into	ADP
gs-4132	318	18	clinical	clinical	ADJ
gs-4132	318	19	practice	practice	NOUN
gs-4132	318	20	.	.	PUNCT
gs-4132	319	1	the	the	DET
gs-4132	319	2	clinical	clinical	ADJ
gs-4132	319	3	translation	translation	NOUN
gs-4132	319	4	of	of	ADP
gs-4132	319	5	exosomes	exosome	NOUN
gs-4132	319	6	and	and	CCONJ
gs-4132	319	7	synthetic	synthetic	ADJ
gs-4132	319	8	nanocarriers	nanocarrier	NOUN
gs-4132	319	9	continues	continue	VERB
gs-4132	319	10	to	to	PART
gs-4132	319	11	advance	advance	VERB
gs-4132	319	12	,	,	PUNCT
gs-4132	319	13	with	with	ADP
gs-4132	319	14	several	several	ADJ
gs-4132	319	15	promising	promising	ADJ
gs-4132	319	16	candidates	candidate	NOUN
gs-4132	319	17	entering	enter	VERB
gs-4132	319	18	early	early	ADJ
gs-4132	319	19	-	-	PUNCT
gs-4132	319	20	phase	phase	NOUN
gs-4132	319	21	trials	trial	NOUN
gs-4132	319	22	.	.	PUNCT
gs-4132	320	1	exosome	exosome	NOUN
gs-4132	320	2	-	-	PUNCT
gs-4132	320	3	based	base	VERB
gs-4132	320	4	therapeutics	therapeutic	NOUN
gs-4132	320	5	have	have	AUX
gs-4132	320	6	been	be	AUX
gs-4132	320	7	investigated	investigate	VERB
gs-4132	320	8	in	in	ADP
gs-4132	320	9	cancer	cancer	NOUN
gs-4132	320	10	immunotherapy	immunotherapy	NOUN
gs-4132	320	11	,	,	PUNCT
gs-4132	320	12	neurological	neurological	ADJ
gs-4132	320	13	disorders	disorder	NOUN
gs-4132	320	14	,	,	PUNCT
gs-4132	320	15	and	and	CCONJ
gs-4132	320	16	cardiovascular	cardiovascular	ADJ
gs-4132	320	17	diseases	disease	NOUN
gs-4132	320	18	,	,	PUNCT
gs-4132	320	19	demonstrating	demonstrate	VERB
gs-4132	320	20	preliminary	preliminary	ADJ
gs-4132	320	21	efficacy	efficacy	NOUN
gs-4132	320	22	and	and	CCONJ
gs-4132	320	23	favorable	favorable	ADJ
gs-4132	320	24	safety	safety	NOUN
gs-4132	320	25	profiles	profile	NOUN
gs-4132	320	26	.	.	PUNCT
gs-4132	321	1	synthetic	synthetic	ADJ
gs-4132	321	2	nanocarriers	nanocarrier	NOUN
gs-4132	321	3	have	have	AUX
gs-4132	321	4	already	already	ADV
gs-4132	321	5	achieved	achieve	VERB
gs-4132	321	6	significant	significant	ADJ
gs-4132	321	7	clinical	clinical	ADJ
gs-4132	321	8	success	success	NOUN
gs-4132	321	9	,	,	PUNCT
gs-4132	321	10	particularly	particularly	ADV
gs-4132	321	11	in	in	ADP
gs-4132	321	12	oncology	oncology	NOUN
gs-4132	321	13	and	and	CCONJ
gs-4132	321	14	infectious	infectious	ADJ
gs-4132	321	15	disease	disease	NOUN
gs-4132	321	16	,	,	PUNCT
gs-4132	321	17	with	with	ADP
gs-4132	321	18	approved	approve	VERB
gs-4132	321	19	liposomal	liposomal	ADJ
gs-4132	321	20	formulations	formulation	NOUN
gs-4132	321	21	and	and	CCONJ
gs-4132	321	22	mrna	mrna	PROPN
gs-4132	321	23	vaccine	vaccine	NOUN
gs-4132	321	24	platforms	platform	NOUN
gs-4132	321	25	serving	serve	VERB
gs-4132	321	26	as	as	ADP
gs-4132	321	27	transformative	transformative	ADJ
gs-4132	321	28	examples	example	NOUN
gs-4132	321	29	.	.	PUNCT
gs-4132	322	1	despite	despite	SCONJ
gs-4132	322	2	these	these	DET
gs-4132	322	3	achievements	achievement	NOUN
gs-4132	322	4	,	,	PUNCT
gs-4132	322	5	challenges	challenge	NOUN
gs-4132	322	6	persist	persist	VERB
gs-4132	322	7	,	,	PUNCT
gs-4132	322	8	including	include	VERB
gs-4132	322	9	the	the	DET
gs-4132	322	10	need	need	NOUN
gs-4132	322	11	for	for	ADP
gs-4132	322	12	scalable	scalable	ADJ
gs-4132	322	13	production	production	NOUN
gs-4132	322	14	,	,	PUNCT
gs-4132	322	15	rigorous	rigorous	ADJ
gs-4132	322	16	quality	quality	NOUN
gs-4132	322	17	control	control	NOUN
gs-4132	322	18	,	,	PUNCT
gs-4132	322	19	and	and	CCONJ
gs-4132	322	20	comprehensive	comprehensive	ADJ
gs-4132	322	21	evaluation	evaluation	NOUN
gs-4132	322	22	of	of	ADP
gs-4132	322	23	biodistribution	biodistribution	NOUN
gs-4132	322	24	and	and	CCONJ
gs-4132	322	25	pharmacokinetics	pharmacokinetic	NOUN
gs-4132	322	26	.	.	PUNCT
gs-4132	323	1	integration	integration	NOUN
gs-4132	323	2	of	of	ADP
gs-4132	323	3	personalized	personalized	ADJ
gs-4132	323	4	medicine	medicine	NOUN
gs-4132	323	5	approaches	approach	NOUN
gs-4132	323	6	,	,	PUNCT
gs-4132	323	7	where	where	SCONJ
gs-4132	323	8	nanocarrier	nanocarrier	NOUN
gs-4132	323	9	design	design	NOUN
gs-4132	323	10	is	be	AUX
gs-4132	323	11	tailored	tailor	VERB
gs-4132	323	12	to	to	ADP
gs-4132	323	13	individual	individual	ADJ
gs-4132	323	14	patient	patient	ADJ
gs-4132	323	15	profiles	profile	NOUN
gs-4132	323	16	and	and	CCONJ
gs-4132	323	17	disease	disease	NOUN
gs-4132	323	18	characteristics	characteristic	NOUN
gs-4132	323	19	,	,	PUNCT
gs-4132	323	20	may	may	AUX
gs-4132	323	21	further	far	ADV
gs-4132	323	22	enhance	enhance	VERB
gs-4132	323	23	therapeutic	therapeutic	ADJ
gs-4132	323	24	outcomes	outcome	NOUN
gs-4132	323	25	and	and	CCONJ
gs-4132	323	26	minimize	minimize	VERB
gs-4132	323	27	adverse	adverse	ADJ
gs-4132	323	28	effects	effect	NOUN
gs-4132	323	29	.	.	PUNCT
gs-4132	324	1	future	future	ADJ
gs-4132	324	2	perspectives	perspective	NOUN
gs-4132	324	3	in	in	ADP
gs-4132	324	4	the	the	DET
gs-4132	324	5	field	field	NOUN
gs-4132	324	6	are	be	AUX
gs-4132	324	7	increasingly	increasingly	ADV
gs-4132	324	8	focused	focus	VERB
gs-4132	324	9	on	on	ADP
gs-4132	324	10	precision	precision	NOUN
gs-4132	324	11	engineering	engineering	NOUN
gs-4132	324	12	,	,	PUNCT
gs-4132	324	13	multifunctional	multifunctional	ADJ
gs-4132	324	14	therapeutics	therapeutic	NOUN
gs-4132	324	15	,	,	PUNCT
gs-4132	324	16	and	and	CCONJ
gs-4132	324	17	regulatory	regulatory	ADJ
gs-4132	324	18	harmonization	harmonization	NOUN
gs-4132	324	19	.	.	PUNCT
gs-4132	325	1	for	for	ADP
gs-4132	325	2	exosomes	exosome	NOUN
gs-4132	325	3	,	,	PUNCT
gs-4132	325	4	the	the	DET
gs-4132	325	5	development	development	NOUN
gs-4132	325	6	of	of	ADP
gs-4132	325	7	cell	cell	NOUN
gs-4132	325	8	-	-	PUNCT
gs-4132	325	9	free	free	ADJ
gs-4132	325	10	production	production	NOUN
gs-4132	325	11	systems	system	NOUN
gs-4132	325	12	,	,	PUNCT
gs-4132	325	13	engineered	engineer	VERB
gs-4132	325	14	parental	parental	ADJ
gs-4132	325	15	cells	cell	NOUN
gs-4132	325	16	,	,	PUNCT
gs-4132	325	17	and	and	CCONJ
gs-4132	325	18	high	high	ADJ
gs-4132	325	19	-	-	PUNCT
gs-4132	325	20	throughput	throughput	NOUN
gs-4132	325	21	loading	loading	NOUN
gs-4132	325	22	techniques	technique	NOUN
gs-4132	325	23	are	be	AUX
gs-4132	325	24	poised	poise	VERB
gs-4132	325	25	to	to	PART
gs-4132	325	26	improve	improve	VERB
gs-4132	325	27	scalability	scalability	NOUN
gs-4132	325	28	and	and	CCONJ
gs-4132	325	29	consistency	consistency	NOUN
gs-4132	325	30	.	.	PUNCT
gs-4132	326	1	synthetic	synthetic	ADJ
gs-4132	326	2	nanocarriers	nanocarrier	NOUN
gs-4132	326	3	continue	continue	VERB
gs-4132	326	4	to	to	PART
gs-4132	326	5	evolve	evolve	VERB
gs-4132	326	6	toward	toward	ADP
gs-4132	326	7	stimuli	stimulus	NOUN
gs-4132	326	8	-	-	PUNCT
gs-4132	326	9	responsive	responsive	ADJ
gs-4132	326	10	systems	system	NOUN
gs-4132	326	11	,	,	PUNCT
gs-4132	326	12	targeted	target	VERB
gs-4132	326	13	delivery	delivery	NOUN
gs-4132	326	14	through	through	ADP
gs-4132	326	15	receptor	receptor	NOUN
gs-4132	326	16	-	-	PUNCT
gs-4132	326	17	mediated	mediate	VERB
gs-4132	326	18	ligands	ligand	NOUN
gs-4132	326	19	,	,	PUNCT
gs-4132	326	20	and	and	CCONJ
gs-4132	326	21	co	co	NOUN
gs-4132	326	22	-	-	NOUN
gs-4132	326	23	delivery	delivery	NOUN
gs-4132	326	24	platforms	platform	NOUN
gs-4132	326	25	that	that	PRON
gs-4132	326	26	integrate	integrate	VERB
gs-4132	326	27	therapeutic	therapeutic	ADJ
gs-4132	326	28	and	and	CCONJ
gs-4132	326	29	diagnostic	diagnostic	ADJ
gs-4132	326	30	functions	function	NOUN
gs-4132	326	31	.	.	PUNCT
gs-4132	327	1	interdisciplinary	interdisciplinary	ADJ
gs-4132	327	2	collaboration	collaboration	NOUN
gs-4132	327	3	between	between	ADP
gs-4132	327	4	material	material	NOUN
gs-4132	327	5	scientists	scientist	NOUN
gs-4132	327	6	,	,	PUNCT
gs-4132	327	7	biologists	biologist	NOUN
gs-4132	327	8	,	,	PUNCT
gs-4132	327	9	pharmacologists	pharmacologist	NOUN
gs-4132	327	10	,	,	PUNCT
gs-4132	327	11	and	and	CCONJ
gs-4132	327	12	clinicians	clinician	NOUN
gs-4132	327	13	will	will	AUX
gs-4132	327	14	be	be	AUX
gs-4132	327	15	essential	essential	ADJ
gs-4132	327	16	to	to	PART
gs-4132	327	17	address	address	VERB
gs-4132	327	18	the	the	DET
gs-4132	327	19	complex	complex	ADJ
gs-4132	327	20	challenges	challenge	NOUN
gs-4132	327	21	associated	associate	VERB
gs-4132	327	22	with	with	ADP
gs-4132	327	23	clinical	clinical	ADJ
gs-4132	327	24	implementation	implementation	NOUN
gs-4132	327	25	and	and	CCONJ
gs-4132	327	26	regulatory	regulatory	ADJ
gs-4132	327	27	approval	approval	NOUN
gs-4132	327	28	.	.	PUNCT
gs-4132	328	1	additionally	additionally	ADV
gs-4132	328	2	,	,	PUNCT
gs-4132	328	3	computational	computational	ADJ
gs-4132	328	4	modeling	modeling	NOUN
gs-4132	328	5	and	and	CCONJ
gs-4132	328	6	artificial	artificial	ADJ
gs-4132	328	7	intelligence	intelligence	NOUN
gs-4132	328	8	are	be	AUX
gs-4132	328	9	expected	expect	VERB
gs-4132	328	10	to	to	PART
gs-4132	328	11	play	play	VERB
gs-4132	328	12	a	a	DET
gs-4132	328	13	central	central	ADJ
gs-4132	328	14	role	role	NOUN
gs-4132	328	15	in	in	ADP
gs-4132	328	16	optimizing	optimize	VERB
gs-4132	328	17	design	design	NOUN
gs-4132	328	18	parameters	parameter	NOUN
gs-4132	328	19	,	,	PUNCT
gs-4132	328	20	predicting	predict	VERB
gs-4132	328	21	biodistribution	biodistribution	NOUN
gs-4132	328	22	,	,	PUNCT
gs-4132	328	23	and	and	CCONJ
gs-4132	328	24	anticipating	anticipate	VERB
gs-4132	328	25	immunological	immunological	ADJ
gs-4132	328	26	responses	response	NOUN
gs-4132	328	27	,	,	PUNCT
gs-4132	328	28	thereby	thereby	ADV
gs-4132	328	29	accelerating	accelerate	VERB
gs-4132	328	30	the	the	DET
gs-4132	328	31	translation	translation	NOUN
gs-4132	328	32	of	of	ADP
gs-4132	328	33	both	both	CCONJ
gs-4132	328	34	biological	biological	ADJ
gs-4132	328	35	and	and	CCONJ
gs-4132	328	36	synthetic	synthetic	ADJ
gs-4132	328	37	nanocarriers	nanocarrier	NOUN
gs-4132	328	38	from	from	ADP
gs-4132	328	39	bench	bench	NOUN
gs-4132	328	40	to	to	ADP
gs-4132	328	41	bedside	bedside	NOUN
gs-4132	328	42	.	.	PUNCT
gs-4132	329	1	the	the	DET
gs-4132	329	2	comparative	comparative	ADJ
gs-4132	329	3	evaluation	evaluation	NOUN
gs-4132	329	4	of	of	ADP
gs-4132	329	5	exosomes	exosome	NOUN
gs-4132	329	6	and	and	CCONJ
gs-4132	329	7	synthetic	synthetic	ADJ
gs-4132	329	8	nanocarriers	nanocarrier	NOUN
gs-4132	329	9	underscores	underscore	VERB
gs-4132	329	10	the	the	DET
gs-4132	329	11	complementary	complementary	ADJ
gs-4132	329	12	nature	nature	NOUN
gs-4132	329	13	of	of	ADP
gs-4132	329	14	these	these	DET
gs-4132	329	15	platforms	platform	NOUN
gs-4132	329	16	in	in	ADP
gs-4132	329	17	therapeutic	therapeutic	ADJ
gs-4132	329	18	delivery	delivery	NOUN
gs-4132	329	19	.	.	PUNCT
gs-4132	330	1	exosomes	exosome	NOUN
gs-4132	330	2	offer	offer	VERB
gs-4132	330	3	unparalleled	unparalleled	ADJ
gs-4132	330	4	georgian	georgian	NOUN
gs-4132	330	5	scientists/	scientists/	NUM
gs-4132	330	6	.	.	PUNCT
gs-4132	331	1	7	7	NUM
gs-4132	331	2	n	n	DET
gs-4132	331	3	4	4	NUM
gs-4132	331	4	,	,	PUNCT
gs-4132	331	5	2025	2025	NUM
gs-4132	331	6	21	21	NUM
gs-4132	331	7	biological	biological	ADJ
gs-4132	331	8	compatibility	compatibility	NOUN
gs-4132	331	9	,	,	PUNCT
gs-4132	331	10	intrinsic	intrinsic	ADJ
gs-4132	331	11	targeting	targeting	NOUN
gs-4132	331	12	,	,	PUNCT
gs-4132	331	13	and	and	CCONJ
gs-4132	331	14	the	the	DET
gs-4132	331	15	potential	potential	NOUN
gs-4132	331	16	for	for	ADP
gs-4132	331	17	modulation	modulation	NOUN
gs-4132	331	18	of	of	ADP
gs-4132	331	19	complex	complex	ADJ
gs-4132	331	20	physiological	physiological	ADJ
gs-4132	331	21	processes	process	NOUN
gs-4132	331	22	,	,	PUNCT
gs-4132	331	23	while	while	SCONJ
gs-4132	331	24	synthetic	synthetic	ADJ
gs-4132	331	25	nanocarriers	nanocarrier	NOUN
gs-4132	331	26	provide	provide	VERB
gs-4132	331	27	structural	structural	ADJ
gs-4132	331	28	tunability	tunability	NOUN
gs-4132	331	29	,	,	PUNCT
gs-4132	331	30	reproducibility	reproducibility	NOUN
gs-4132	331	31	,	,	PUNCT
gs-4132	331	32	and	and	CCONJ
gs-4132	331	33	multifunctional	multifunctional	ADJ
gs-4132	331	34	capabilities	capability	NOUN
gs-4132	331	35	that	that	PRON
gs-4132	331	36	facilitate	facilitate	VERB
gs-4132	331	37	precise	precise	ADJ
gs-4132	331	38	therapeutic	therapeutic	ADJ
gs-4132	331	39	intervention	intervention	NOUN
gs-4132	331	40	.	.	PUNCT
gs-4132	332	1	the	the	DET
gs-4132	332	2	ongoing	ongoing	ADJ
gs-4132	332	3	convergence	convergence	NOUN
gs-4132	332	4	of	of	ADP
gs-4132	332	5	these	these	DET
gs-4132	332	6	strategies	strategy	NOUN
gs-4132	332	7	into	into	ADP
gs-4132	332	8	hybrid	hybrid	ADJ
gs-4132	332	9	systems	system	NOUN
gs-4132	332	10	holds	hold	VERB
gs-4132	332	11	great	great	ADJ
gs-4132	332	12	promise	promise	NOUN
gs-4132	332	13	for	for	ADP
gs-4132	332	14	overcoming	overcome	VERB
gs-4132	332	15	existing	exist	VERB
gs-4132	332	16	limitations	limitation	NOUN
gs-4132	332	17	and	and	CCONJ
gs-4132	332	18	expanding	expand	VERB
gs-4132	332	19	the	the	DET
gs-4132	332	20	scope	scope	NOUN
gs-4132	332	21	of	of	ADP
gs-4132	332	22	nanomedicine	nanomedicine	NOUN
gs-4132	332	23	.	.	PUNCT
gs-4132	333	1	by	by	ADP
gs-4132	333	2	integrating	integrate	VERB
gs-4132	333	3	advances	advance	NOUN
gs-4132	333	4	in	in	ADP
gs-4132	333	5	molecular	molecular	ADJ
gs-4132	333	6	engineering	engineering	NOUN
gs-4132	333	7	,	,	PUNCT
gs-4132	333	8	material	material	NOUN
gs-4132	333	9	science	science	NOUN
gs-4132	333	10	,	,	PUNCT
gs-4132	333	11	and	and	CCONJ
gs-4132	333	12	computational	computational	ADJ
gs-4132	333	13	modeling	modeling	NOUN
gs-4132	333	14	,	,	PUNCT
gs-4132	333	15	the	the	DET
gs-4132	333	16	next	next	ADJ
gs-4132	333	17	generation	generation	NOUN
gs-4132	333	18	of	of	ADP
gs-4132	333	19	therapeutics	therapeutic	NOUN
gs-4132	333	20	is	be	AUX
gs-4132	333	21	likely	likely	ADJ
gs-4132	333	22	to	to	PART
gs-4132	333	23	harness	harness	VERB
gs-4132	333	24	the	the	DET
gs-4132	333	25	synergistic	synergistic	ADJ
gs-4132	333	26	potential	potential	NOUN
gs-4132	333	27	of	of	ADP
gs-4132	333	28	biological	biological	ADJ
gs-4132	333	29	and	and	CCONJ
gs-4132	333	30	synthetic	synthetic	ADJ
gs-4132	333	31	nanocarriers	nanocarrier	NOUN
gs-4132	333	32	,	,	PUNCT
gs-4132	333	33	ultimately	ultimately	ADV
gs-4132	333	34	advancing	advance	VERB
gs-4132	333	35	precision	precision	NOUN
gs-4132	333	36	medicine	medicine	NOUN
gs-4132	333	37	and	and	CCONJ
gs-4132	333	38	improving	improve	VERB
gs-4132	333	39	patient	patient	ADJ
gs-4132	333	40	outcomes	outcome	NOUN
gs-4132	333	41	across	across	ADP
gs-4132	333	42	a	a	DET
gs-4132	333	43	spectrum	spectrum	NOUN
gs-4132	333	44	of	of	ADP
gs-4132	333	45	diseases	disease	NOUN
gs-4132	333	46	.	.	PUNCT
gs-4132	334	1	continued	continue	VERB
gs-4132	334	2	research	research	NOUN
gs-4132	334	3	,	,	PUNCT
gs-4132	334	4	rigorous	rigorous	ADJ
gs-4132	334	5	standardization	standardization	NOUN
gs-4132	334	6	,	,	PUNCT
gs-4132	334	7	and	and	CCONJ
gs-4132	334	8	interdisciplinary	interdisciplinary	ADJ
gs-4132	334	9	collaboration	collaboration	NOUN
gs-4132	334	10	remain	remain	VERB
gs-4132	334	11	pivotal	pivotal	ADJ
gs-4132	334	12	to	to	ADP
gs-4132	334	13	unlocking	unlock	VERB
gs-4132	334	14	the	the	DET
gs-4132	334	15	full	full	ADJ
gs-4132	334	16	potential	potential	NOUN
gs-4132	334	17	of	of	ADP
gs-4132	334	18	these	these	DET
gs-4132	334	19	innovative	innovative	ADJ
gs-4132	334	20	delivery	delivery	NOUN
gs-4132	334	21	systems	system	NOUN
gs-4132	334	22	,	,	PUNCT
gs-4132	334	23	establishing	establish	VERB
gs-4132	334	24	a	a	DET
gs-4132	334	25	foundation	foundation	NOUN
gs-4132	334	26	for	for	ADP
gs-4132	334	27	transformative	transformative	ADJ
gs-4132	334	28	advances	advance	NOUN
gs-4132	334	29	in	in	ADP
gs-4132	334	30	healthcare	healthcare	NOUN
gs-4132	334	31	and	and	CCONJ
gs-4132	334	32	therapeutic	therapeutic	ADJ
gs-4132	334	33	innovation	innovation	NOUN
gs-4132	334	34	.	.	PUNCT
gs-4132	335	1	the	the	DET
gs-4132	335	2	dynamic	dynamic	ADJ
gs-4132	335	3	interplay	interplay	NOUN
gs-4132	335	4	between	between	ADP
gs-4132	335	5	exosomes	exosome	NOUN
gs-4132	335	6	and	and	CCONJ
gs-4132	335	7	synthetic	synthetic	ADJ
gs-4132	335	8	nanocarriers	nanocarrier	NOUN
gs-4132	335	9	reflects	reflect	VERB
gs-4132	335	10	the	the	DET
gs-4132	335	11	broader	broad	ADJ
gs-4132	335	12	evolution	evolution	NOUN
gs-4132	335	13	of	of	ADP
gs-4132	335	14	nanomedicine	nanomedicine	NOUN
gs-4132	335	15	,	,	PUNCT
gs-4132	335	16	where	where	SCONJ
gs-4132	335	17	the	the	DET
gs-4132	335	18	focus	focus	NOUN
gs-4132	335	19	has	have	AUX
gs-4132	335	20	shifted	shift	VERB
gs-4132	335	21	from	from	ADP
gs-4132	335	22	simple	simple	ADJ
gs-4132	335	23	drug	drug	NOUN
gs-4132	335	24	delivery	delivery	NOUN
gs-4132	335	25	vehicles	vehicle	NOUN
gs-4132	335	26	to	to	ADP
gs-4132	335	27	highly	highly	ADV
gs-4132	335	28	sophisticated	sophisticated	ADJ
gs-4132	335	29	,	,	PUNCT
gs-4132	335	30	multifunctional	multifunctional	ADJ
gs-4132	335	31	therapeutic	therapeutic	ADJ
gs-4132	335	32	systems	system	NOUN
gs-4132	335	33	capable	capable	ADJ
gs-4132	335	34	of	of	ADP
gs-4132	335	35	modulating	modulate	VERB
gs-4132	335	36	cellular	cellular	ADJ
gs-4132	335	37	environments	environment	NOUN
gs-4132	335	38	with	with	ADP
gs-4132	335	39	precision	precision	NOUN
gs-4132	335	40	.	.	PUNCT
gs-4132	336	1	exosomes	exosome	NOUN
gs-4132	336	2	,	,	PUNCT
gs-4132	336	3	as	as	SCONJ
gs-4132	336	4	naturally	naturally	ADV
gs-4132	336	5	secreted	secrete	VERB
gs-4132	336	6	extracellular	extracellular	ADJ
gs-4132	336	7	vesicles	vesicle	NOUN
gs-4132	336	8	,	,	PUNCT
gs-4132	336	9	inherently	inherently	ADV
gs-4132	336	10	reflect	reflect	VERB
gs-4132	336	11	the	the	DET
gs-4132	336	12	biological	biological	ADJ
gs-4132	336	13	state	state	NOUN
gs-4132	336	14	of	of	ADP
gs-4132	336	15	their	their	PRON
gs-4132	336	16	parent	parent	NOUN
gs-4132	336	17	cells	cell	NOUN
gs-4132	336	18	,	,	PUNCT
gs-4132	336	19	carrying	carry	VERB
gs-4132	336	20	complex	complex	ADJ
gs-4132	336	21	molecular	molecular	ADJ
gs-4132	336	22	cargo	cargo	NOUN
gs-4132	336	23	that	that	PRON
gs-4132	336	24	includes	include	VERB
gs-4132	336	25	proteins	protein	NOUN
gs-4132	336	26	,	,	PUNCT
gs-4132	336	27	lipids	lipid	NOUN
gs-4132	336	28	,	,	PUNCT
gs-4132	336	29	rnas	rna	NOUN
gs-4132	336	30	,	,	PUNCT
gs-4132	336	31	and	and	CCONJ
gs-4132	336	32	metabolites	metabolite	NOUN
gs-4132	336	33	.	.	PUNCT
gs-4132	337	1	this	this	DET
gs-4132	337	2	cargo	cargo	NOUN
gs-4132	337	3	is	be	AUX
gs-4132	337	4	not	not	PART
gs-4132	337	5	merely	merely	ADV
gs-4132	337	6	passive	passive	ADJ
gs-4132	337	7	;	;	PUNCT
gs-4132	337	8	it	it	PRON
gs-4132	337	9	actively	actively	ADV
gs-4132	337	10	participates	participate	VERB
gs-4132	337	11	in	in	ADP
gs-4132	337	12	intercellular	intercellular	ADJ
gs-4132	337	13	communication	communication	NOUN
gs-4132	337	14	,	,	PUNCT
gs-4132	337	15	influencing	influence	VERB
gs-4132	337	16	gene	gene	NOUN
gs-4132	337	17	expression	expression	NOUN
gs-4132	337	18	,	,	PUNCT
gs-4132	337	19	cellular	cellular	ADJ
gs-4132	337	20	metabolism	metabolism	NOUN
gs-4132	337	21	,	,	PUNCT
gs-4132	337	22	immune	immune	ADJ
gs-4132	337	23	responses	response	NOUN
gs-4132	337	24	,	,	PUNCT
gs-4132	337	25	and	and	CCONJ
gs-4132	337	26	even	even	ADV
gs-4132	337	27	the	the	DET
gs-4132	337	28	tumor	tumor	NOUN
gs-4132	337	29	microenvironment	microenvironment	NOUN
gs-4132	337	30	.	.	PUNCT
gs-4132	338	1	the	the	DET
gs-4132	338	2	therapeutic	therapeutic	ADJ
gs-4132	338	3	potential	potential	NOUN
gs-4132	338	4	of	of	ADP
gs-4132	338	5	exosomes	exosome	NOUN
gs-4132	338	6	,	,	PUNCT
gs-4132	338	7	therefore	therefore	ADV
gs-4132	338	8	,	,	PUNCT
gs-4132	338	9	lies	lie	VERB
gs-4132	338	10	not	not	PART
gs-4132	338	11	only	only	ADV
gs-4132	338	12	in	in	ADP
gs-4132	338	13	their	their	PRON
gs-4132	338	14	ability	ability	NOUN
gs-4132	338	15	to	to	PART
gs-4132	338	16	transport	transport	VERB
gs-4132	338	17	exogenous	exogenous	ADJ
gs-4132	338	18	drugs	drug	NOUN
gs-4132	338	19	but	but	CCONJ
gs-4132	338	20	also	also	ADV
gs-4132	338	21	in	in	ADP
gs-4132	338	22	their	their	PRON
gs-4132	338	23	intrinsic	intrinsic	ADJ
gs-4132	338	24	bioactivity	bioactivity	NOUN
gs-4132	338	25	,	,	PUNCT
gs-4132	338	26	which	which	PRON
gs-4132	338	27	can	can	AUX
gs-4132	338	28	synergize	synergize	VERB
gs-4132	338	29	with	with	ADP
gs-4132	338	30	delivered	deliver	VERB
gs-4132	338	31	therapeutics	therapeutic	NOUN
gs-4132	338	32	to	to	PART
gs-4132	338	33	amplify	amplify	VERB
gs-4132	338	34	therapeutic	therapeutic	ADJ
gs-4132	338	35	effects	effect	NOUN
gs-4132	338	36	.	.	PUNCT
gs-4132	339	1	a	a	DET
gs-4132	339	2	critical	critical	ADJ
gs-4132	339	3	aspect	aspect	NOUN
gs-4132	339	4	of	of	ADP
gs-4132	339	5	exosome	exosome	PROPN
gs-4132	339	6	biology	biology	NOUN
gs-4132	339	7	is	be	AUX
gs-4132	339	8	their	their	PRON
gs-4132	339	9	heterogeneity	heterogeneity	NOUN
gs-4132	339	10	,	,	PUNCT
gs-4132	339	11	which	which	PRON
gs-4132	339	12	can	can	AUX
gs-4132	339	13	be	be	AUX
gs-4132	339	14	both	both	CCONJ
gs-4132	339	15	a	a	DET
gs-4132	339	16	challenge	challenge	NOUN
gs-4132	339	17	and	and	CCONJ
gs-4132	339	18	an	an	DET
gs-4132	339	19	opportunity	opportunity	NOUN
gs-4132	339	20	.	.	PUNCT
gs-4132	340	1	exosomes	exosome	NOUN
gs-4132	340	2	vary	vary	VERB
gs-4132	340	3	in	in	ADP
gs-4132	340	4	size	size	NOUN
gs-4132	340	5	,	,	PUNCT
gs-4132	340	6	surface	surface	NOUN
gs-4132	340	7	marker	marker	NOUN
gs-4132	340	8	composition	composition	NOUN
gs-4132	340	9	,	,	PUNCT
gs-4132	340	10	and	and	CCONJ
gs-4132	340	11	cargo	cargo	NOUN
gs-4132	340	12	content	content	NOUN
gs-4132	340	13	depending	depend	VERB
gs-4132	340	14	on	on	ADP
gs-4132	340	15	the	the	DET
gs-4132	340	16	cell	cell	NOUN
gs-4132	340	17	of	of	ADP
gs-4132	340	18	origin	origin	NOUN
gs-4132	340	19	,	,	PUNCT
gs-4132	340	20	the	the	DET
gs-4132	340	21	physiological	physiological	ADJ
gs-4132	340	22	or	or	CCONJ
gs-4132	340	23	pathological	pathological	ADJ
gs-4132	340	24	state	state	NOUN
gs-4132	340	25	of	of	ADP
gs-4132	340	26	the	the	DET
gs-4132	340	27	donor	donor	NOUN
gs-4132	340	28	cell	cell	NOUN
gs-4132	340	29	,	,	PUNCT
gs-4132	340	30	and	and	CCONJ
gs-4132	340	31	environmental	environmental	ADJ
gs-4132	340	32	factors	factor	NOUN
gs-4132	340	33	.	.	PUNCT
gs-4132	341	1	this	this	DET
gs-4132	341	2	heterogeneity	heterogeneity	NOUN
gs-4132	341	3	can	can	AUX
gs-4132	341	4	influence	influence	VERB
gs-4132	341	5	biodistribution	biodistribution	NOUN
gs-4132	341	6	,	,	PUNCT
gs-4132	341	7	cellular	cellular	ADJ
gs-4132	341	8	uptake	uptake	NOUN
gs-4132	341	9	,	,	PUNCT
gs-4132	341	10	and	and	CCONJ
gs-4132	341	11	therapeutic	therapeutic	ADJ
gs-4132	341	12	efficacy	efficacy	NOUN
gs-4132	341	13	.	.	PUNCT
gs-4132	342	1	for	for	ADP
gs-4132	342	2	example	example	NOUN
gs-4132	342	3	,	,	PUNCT
gs-4132	342	4	mesenchymal	mesenchymal	ADJ
gs-4132	342	5	stem	stem	NOUN
gs-4132	342	6	cell	cell	NOUN
gs-4132	342	7	-	-	PUNCT
gs-4132	342	8	derived	derive	VERB
gs-4132	342	9	exosomes	exosome	NOUN
gs-4132	342	10	exhibit	exhibit	VERB
gs-4132	342	11	immunomodulatory	immunomodulatory	ADJ
gs-4132	342	12	and	and	CCONJ
gs-4132	342	13	regenerative	regenerative	ADJ
gs-4132	342	14	properties	property	NOUN
gs-4132	342	15	that	that	PRON
gs-4132	342	16	make	make	VERB
gs-4132	342	17	them	they	PRON
gs-4132	342	18	suitable	suitable	ADJ
gs-4132	342	19	for	for	ADP
gs-4132	342	20	cardiovascular	cardiovascular	ADJ
gs-4132	342	21	repair	repair	NOUN
gs-4132	342	22	or	or	CCONJ
gs-4132	342	23	inflammatory	inflammatory	ADJ
gs-4132	342	24	disorders	disorder	NOUN
gs-4132	342	25	,	,	PUNCT
gs-4132	342	26	whereas	whereas	SCONJ
gs-4132	342	27	tumor	tumor	NOUN
gs-4132	342	28	-	-	PUNCT
gs-4132	342	29	derived	derive	VERB
gs-4132	342	30	exosomes	exosome	NOUN
gs-4132	342	31	often	often	ADV
gs-4132	342	32	carry	carry	VERB
gs-4132	342	33	oncogenic	oncogenic	ADJ
gs-4132	342	34	molecules	molecule	NOUN
gs-4132	342	35	that	that	PRON
gs-4132	342	36	can	can	AUX
gs-4132	342	37	promote	promote	VERB
gs-4132	342	38	metastasis	metastasis	PRON
gs-4132	342	39	and	and	CCONJ
gs-4132	342	40	immune	immune	ADJ
gs-4132	342	41	evasion	evasion	NOUN
gs-4132	342	42	.	.	PUNCT
gs-4132	343	1	understanding	understanding	NOUN
gs-4132	343	2	and	and	CCONJ
gs-4132	343	3	harnessing	harness	VERB
gs-4132	343	4	this	this	DET
gs-4132	343	5	heterogeneity	heterogeneity	NOUN
gs-4132	343	6	is	be	AUX
gs-4132	343	7	central	central	ADJ
gs-4132	343	8	to	to	ADP
gs-4132	343	9	the	the	DET
gs-4132	343	10	design	design	NOUN
gs-4132	343	11	of	of	ADP
gs-4132	343	12	targeted	target	VERB
gs-4132	343	13	therapies	therapy	NOUN
gs-4132	343	14	.	.	PUNCT
gs-4132	344	1	approaches	approach	NOUN
gs-4132	344	2	such	such	ADJ
gs-4132	344	3	as	as	ADP
gs-4132	344	4	selective	selective	ADJ
gs-4132	344	5	enrichment	enrichment	NOUN
gs-4132	344	6	,	,	PUNCT
gs-4132	344	7	surface	surface	NOUN
gs-4132	344	8	functionalization	functionalization	NOUN
gs-4132	344	9	,	,	PUNCT
gs-4132	344	10	and	and	CCONJ
gs-4132	344	11	cargo	cargo	NOUN
gs-4132	344	12	engineering	engineering	NOUN
gs-4132	344	13	are	be	AUX
gs-4132	344	14	increasingly	increasingly	ADV
gs-4132	344	15	used	use	VERB
gs-4132	344	16	to	to	PART
gs-4132	344	17	create	create	VERB
gs-4132	344	18	exosome	exosome	NOUN
gs-4132	344	19	populations	population	NOUN
gs-4132	344	20	tailored	tailor	VERB
gs-4132	344	21	for	for	ADP
gs-4132	344	22	specific	specific	ADJ
gs-4132	344	23	therapeutic	therapeutic	ADJ
gs-4132	344	24	purposes	purpose	NOUN
gs-4132	344	25	,	,	PUNCT
gs-4132	344	26	thereby	thereby	ADV
gs-4132	344	27	transforming	transform	VERB
gs-4132	344	28	natural	natural	ADJ
gs-4132	344	29	variability	variability	NOUN
gs-4132	344	30	into	into	ADP
gs-4132	344	31	a	a	DET
gs-4132	344	32	controllable	controllable	ADJ
gs-4132	344	33	feature	feature	NOUN
gs-4132	344	34	.	.	PUNCT
gs-4132	345	1	synthetic	synthetic	ADJ
gs-4132	345	2	nanocarriers	nanocarrier	NOUN
gs-4132	345	3	,	,	PUNCT
gs-4132	345	4	in	in	ADP
gs-4132	345	5	contrast	contrast	NOUN
gs-4132	345	6	,	,	PUNCT
gs-4132	345	7	offer	offer	VERB
gs-4132	345	8	precise	precise	ADJ
gs-4132	345	9	control	control	NOUN
gs-4132	345	10	over	over	ADP
gs-4132	345	11	physicochemical	physicochemical	ADJ
gs-4132	345	12	characteristics	characteristic	NOUN
gs-4132	345	13	,	,	PUNCT
gs-4132	345	14	enabling	enable	VERB
gs-4132	345	15	customization	customization	NOUN
gs-4132	345	16	of	of	ADP
gs-4132	345	17	particle	particle	NOUN
gs-4132	345	18	size	size	NOUN
gs-4132	345	19	,	,	PUNCT
gs-4132	345	20	surface	surface	NOUN
gs-4132	345	21	charge	charge	NOUN
gs-4132	345	22	,	,	PUNCT
gs-4132	345	23	hydrophobicity	hydrophobicity	NOUN
gs-4132	345	24	,	,	PUNCT
gs-4132	345	25	and	and	CCONJ
gs-4132	345	26	functionalization	functionalization	NOUN
gs-4132	345	27	with	with	ADP
gs-4132	345	28	ligands	ligand	NOUN
gs-4132	345	29	or	or	CCONJ
gs-4132	345	30	antibodies	antibody	NOUN
gs-4132	345	31	.	.	PUNCT
gs-4132	346	1	this	this	DET
gs-4132	346	2	tunability	tunability	NOUN
gs-4132	346	3	allows	allow	VERB
gs-4132	346	4	synthetic	synthetic	ADJ
gs-4132	346	5	systems	system	NOUN
gs-4132	346	6	to	to	PART
gs-4132	346	7	be	be	AUX
gs-4132	346	8	adapted	adapt	VERB
gs-4132	346	9	to	to	ADP
gs-4132	346	10	specific	specific	ADJ
gs-4132	346	11	therapeutic	therapeutic	ADJ
gs-4132	346	12	contexts	contexts	NOUN
gs-4132	346	13	.	.	PUNCT
gs-4132	347	1	for	for	ADP
gs-4132	347	2	instance	instance	NOUN
gs-4132	347	3	,	,	PUNCT
gs-4132	347	4	liposomes	liposome	NOUN
gs-4132	347	5	with	with	ADP
gs-4132	347	6	neutral	neutral	ADJ
gs-4132	347	7	or	or	CCONJ
gs-4132	347	8	slightly	slightly	ADV
gs-4132	347	9	negative	negative	ADJ
gs-4132	347	10	charges	charge	NOUN
gs-4132	347	11	can	can	AUX
gs-4132	347	12	achieve	achieve	VERB
gs-4132	347	13	extended	extended	ADJ
gs-4132	347	14	circulation	circulation	NOUN
gs-4132	347	15	time	time	NOUN
gs-4132	347	16	by	by	ADP
gs-4132	347	17	reducing	reduce	VERB
gs-4132	347	18	opsonization	opsonization	NOUN
gs-4132	347	19	,	,	PUNCT
gs-4132	347	20	while	while	SCONJ
gs-4132	347	21	positively	positively	ADV
gs-4132	347	22	charged	charge	VERB
gs-4132	347	23	polymeric	polymeric	ADJ
gs-4132	347	24	nanoparticles	nanoparticle	NOUN
gs-4132	347	25	can	can	AUX
gs-4132	347	26	enhance	enhance	VERB
gs-4132	347	27	endosomal	endosomal	ADJ
gs-4132	347	28	escape	escape	NOUN
gs-4132	347	29	and	and	CCONJ
gs-4132	347	30	intracellular	intracellular	ADJ
gs-4132	347	31	delivery	delivery	NOUN
gs-4132	347	32	of	of	ADP
gs-4132	347	33	nucleic	nucleic	ADJ
gs-4132	347	34	acids	acid	NOUN
gs-4132	347	35	.	.	PUNCT
gs-4132	348	1	dendrimers	dendrimer	NOUN
gs-4132	348	2	and	and	CCONJ
gs-4132	348	3	other	other	ADJ
gs-4132	348	4	branched	branched	ADJ
gs-4132	348	5	polymeric	polymeric	ADJ
gs-4132	348	6	structures	structure	NOUN
gs-4132	348	7	provide	provide	VERB
gs-4132	348	8	multivalent	multivalent	NOUN
gs-4132	348	9	surface	surface	NOUN
gs-4132	348	10	presentation	presentation	NOUN
gs-4132	348	11	,	,	PUNCT
gs-4132	348	12	facilitating	facilitate	VERB
gs-4132	348	13	targeted	target	VERB
gs-4132	348	14	binding	bind	VERB
gs-4132	348	15	to	to	ADP
gs-4132	348	16	receptors	receptor	NOUN
gs-4132	348	17	overexpressed	overexpresse	VERB
gs-4132	348	18	on	on	ADP
gs-4132	348	19	diseased	diseased	ADJ
gs-4132	348	20	cells	cell	NOUN
gs-4132	348	21	,	,	PUNCT
gs-4132	348	22	and	and	CCONJ
gs-4132	348	23	enabling	enable	VERB
gs-4132	348	24	co	co	NOUN
gs-4132	348	25	-	-	NOUN
gs-4132	348	26	delivery	delivery	NOUN
gs-4132	348	27	of	of	ADP
gs-4132	348	28	multiple	multiple	ADJ
gs-4132	348	29	therapeutic	therapeutic	ADJ
gs-4132	348	30	agents	agent	NOUN
gs-4132	348	31	.	.	PUNCT
gs-4132	349	1	the	the	DET
gs-4132	349	2	precise	precise	ADJ
gs-4132	349	3	engineering	engineering	NOUN
gs-4132	349	4	georgian	georgian	NOUN
gs-4132	349	5	scientists/	scientists/	NUM
gs-4132	349	6	.	.	PUNCT
gs-4132	350	1	7	7	NUM
gs-4132	350	2	n	n	DET
gs-4132	350	3	4	4	NUM
gs-4132	350	4	,	,	PUNCT
gs-4132	350	5	2025	2025	NUM
gs-4132	350	6	22	22	NUM
gs-4132	350	7	of	of	ADP
gs-4132	350	8	these	these	DET
gs-4132	350	9	synthetic	synthetic	ADJ
gs-4132	350	10	systems	system	NOUN
gs-4132	350	11	facilitates	facilitate	VERB
gs-4132	350	12	reproducibility	reproducibility	NOUN
gs-4132	350	13	,	,	PUNCT
gs-4132	350	14	scalability	scalability	NOUN
gs-4132	350	15	,	,	PUNCT
gs-4132	350	16	and	and	CCONJ
gs-4132	350	17	regulatory	regulatory	ADJ
gs-4132	350	18	compliance	compliance	NOUN
gs-4132	350	19	,	,	PUNCT
gs-4132	350	20	making	make	VERB
gs-4132	350	21	them	they	PRON
gs-4132	350	22	well	well	ADV
gs-4132	350	23	-	-	PUNCT
gs-4132	350	24	suited	suit	VERB
gs-4132	350	25	for	for	ADP
gs-4132	350	26	clinical	clinical	ADJ
gs-4132	350	27	translation	translation	NOUN
gs-4132	350	28	,	,	PUNCT
gs-4132	350	29	even	even	ADV
gs-4132	350	30	if	if	SCONJ
gs-4132	350	31	they	they	PRON
gs-4132	350	32	lack	lack	VERB
gs-4132	350	33	the	the	DET
gs-4132	350	34	inherent	inherent	ADJ
gs-4132	350	35	bioactivity	bioactivity	NOUN
gs-4132	350	36	of	of	ADP
gs-4132	350	37	natural	natural	ADJ
gs-4132	350	38	exosomes	exosome	NOUN
gs-4132	350	39	.	.	PUNCT
gs-4132	351	1	the	the	DET
gs-4132	351	2	mechanisms	mechanism	NOUN
gs-4132	351	3	of	of	ADP
gs-4132	351	4	uptake	uptake	ADJ
gs-4132	351	5	and	and	CCONJ
gs-4132	351	6	intracellular	intracellular	ADJ
gs-4132	351	7	trafficking	trafficking	NOUN
gs-4132	351	8	differ	differ	VERB
gs-4132	351	9	markedly	markedly	ADV
gs-4132	351	10	between	between	ADP
gs-4132	351	11	exosomes	exosome	NOUN
gs-4132	351	12	and	and	CCONJ
gs-4132	351	13	synthetic	synthetic	ADJ
gs-4132	351	14	nanocarriers	nanocarrier	NOUN
gs-4132	351	15	,	,	PUNCT
gs-4132	351	16	with	with	ADP
gs-4132	351	17	implications	implication	NOUN
gs-4132	351	18	for	for	ADP
gs-4132	351	19	efficacy	efficacy	NOUN
gs-4132	351	20	and	and	CCONJ
gs-4132	351	21	safety	safety	NOUN
gs-4132	351	22	.	.	PUNCT
gs-4132	352	1	exosomes	exosome	NOUN
gs-4132	352	2	primarily	primarily	ADV
gs-4132	352	3	exploit	exploit	VERB
gs-4132	352	4	receptor	receptor	NOUN
gs-4132	352	5	-	-	PUNCT
gs-4132	352	6	mediated	mediate	VERB
gs-4132	352	7	endocytosis	endocytosis	NOUN
gs-4132	352	8	and	and	CCONJ
gs-4132	352	9	direct	direct	ADJ
gs-4132	352	10	membrane	membrane	NOUN
gs-4132	352	11	fusion	fusion	NOUN
gs-4132	352	12	,	,	PUNCT
gs-4132	352	13	allowing	allow	VERB
gs-4132	352	14	for	for	ADP
gs-4132	352	15	targeted	target	VERB
gs-4132	352	16	delivery	delivery	NOUN
gs-4132	352	17	and	and	CCONJ
gs-4132	352	18	evasion	evasion	NOUN
gs-4132	352	19	of	of	ADP
gs-4132	352	20	lysosomal	lysosomal	ADJ
gs-4132	352	21	degradation	degradation	NOUN
gs-4132	352	22	.	.	PUNCT
gs-4132	353	1	this	this	DET
gs-4132	353	2	capability	capability	NOUN
gs-4132	353	3	is	be	AUX
gs-4132	353	4	particularly	particularly	ADV
gs-4132	353	5	important	important	ADJ
gs-4132	353	6	when	when	SCONJ
gs-4132	353	7	delivering	deliver	VERB
gs-4132	353	8	labile	labile	ADJ
gs-4132	353	9	biomolecules	biomolecule	NOUN
gs-4132	353	10	such	such	ADJ
gs-4132	353	11	as	as	ADP
gs-4132	353	12	rnas	rna	NOUN
gs-4132	353	13	or	or	CCONJ
gs-4132	353	14	proteins	protein	NOUN
gs-4132	353	15	,	,	PUNCT
gs-4132	353	16	which	which	PRON
gs-4132	353	17	are	be	AUX
gs-4132	353	18	susceptible	susceptible	ADJ
gs-4132	353	19	to	to	ADP
gs-4132	353	20	enzymatic	enzymatic	ADJ
gs-4132	353	21	degradation	degradation	NOUN
gs-4132	353	22	in	in	ADP
gs-4132	353	23	the	the	DET
gs-4132	353	24	endolysosomal	endolysosomal	ADJ
gs-4132	353	25	pathway	pathway	NOUN
gs-4132	353	26	.	.	PUNCT
gs-4132	354	1	synthetic	synthetic	ADJ
gs-4132	354	2	nanoparticles	nanoparticle	NOUN
gs-4132	354	3	,	,	PUNCT
gs-4132	354	4	while	while	SCONJ
gs-4132	354	5	capable	capable	ADJ
gs-4132	354	6	of	of	ADP
gs-4132	354	7	receptor	receptor	NOUN
gs-4132	354	8	-	-	PUNCT
gs-4132	354	9	mediated	mediate	VERB
gs-4132	354	10	internalization	internalization	NOUN
gs-4132	354	11	,	,	PUNCT
gs-4132	354	12	often	often	ADV
gs-4132	354	13	face	face	VERB
gs-4132	354	14	challenges	challenge	NOUN
gs-4132	354	15	in	in	ADP
gs-4132	354	16	endosomal	endosomal	ADJ
gs-4132	354	17	escape	escape	NOUN
gs-4132	354	18	,	,	PUNCT
gs-4132	354	19	necessitating	necessitate	VERB
gs-4132	354	20	the	the	DET
gs-4132	354	21	incorporation	incorporation	NOUN
gs-4132	354	22	of	of	ADP
gs-4132	354	23	ph	ph	ADJ
gs-4132	354	24	-	-	ADJ
gs-4132	354	25	sensitive	sensitive	ADJ
gs-4132	354	26	polymers	polymer	NOUN
gs-4132	354	27	,	,	PUNCT
gs-4132	354	28	membrane	membrane	NOUN
gs-4132	354	29	-	-	PUNCT
gs-4132	354	30	disruptive	disruptive	ADJ
gs-4132	354	31	peptides	peptide	NOUN
gs-4132	354	32	,	,	PUNCT
gs-4132	354	33	or	or	CCONJ
gs-4132	354	34	other	other	ADJ
gs-4132	354	35	endosomolytic	endosomolytic	ADJ
gs-4132	354	36	strategies	strategy	NOUN
gs-4132	354	37	to	to	PART
gs-4132	354	38	ensure	ensure	VERB
gs-4132	354	39	the	the	DET
gs-4132	354	40	functional	functional	ADJ
gs-4132	354	41	delivery	delivery	NOUN
gs-4132	354	42	of	of	ADP
gs-4132	354	43	cargo	cargo	NOUN
gs-4132	354	44	.	.	PUNCT
gs-4132	355	1	the	the	DET
gs-4132	355	2	differential	differential	ADJ
gs-4132	355	3	trafficking	trafficking	NOUN
gs-4132	355	4	pathways	pathway	NOUN
gs-4132	355	5	also	also	ADV
gs-4132	355	6	influence	influence	VERB
gs-4132	355	7	pharmacokinetics	pharmacokinetic	NOUN
gs-4132	355	8	and	and	CCONJ
gs-4132	355	9	biodistribution	biodistribution	NOUN
gs-4132	355	10	;	;	PUNCT
gs-4132	355	11	exosomes	exosome	NOUN
gs-4132	355	12	may	may	AUX
gs-4132	355	13	preferentially	preferentially	ADV
gs-4132	355	14	accumulate	accumulate	VERB
gs-4132	355	15	in	in	ADP
gs-4132	355	16	tissues	tissue	NOUN
gs-4132	355	17	reflective	reflective	ADJ
gs-4132	355	18	of	of	ADP
gs-4132	355	19	their	their	PRON
gs-4132	355	20	parental	parental	ADJ
gs-4132	355	21	cell	cell	NOUN
gs-4132	355	22	tropism	tropism	NOUN
gs-4132	355	23	,	,	PUNCT
gs-4132	355	24	whereas	whereas	SCONJ
gs-4132	355	25	synthetic	synthetic	ADJ
gs-4132	355	26	particles	particle	NOUN
gs-4132	355	27	can	can	AUX
gs-4132	355	28	be	be	AUX
gs-4132	355	29	engineered	engineer	VERB
gs-4132	355	30	to	to	PART
gs-4132	355	31	target	target	VERB
gs-4132	355	32	specific	specific	ADJ
gs-4132	355	33	organs	organ	NOUN
gs-4132	355	34	,	,	PUNCT
gs-4132	355	35	albeit	albeit	SCONJ
gs-4132	355	36	with	with	ADP
gs-4132	355	37	the	the	DET
gs-4132	355	38	risk	risk	NOUN
gs-4132	355	39	of	of	ADP
gs-4132	355	40	off	off	ADP
gs-4132	355	41	-	-	PUNCT
gs-4132	355	42	target	target	NOUN
gs-4132	355	43	accumulation	accumulation	NOUN
gs-4132	355	44	and	and	CCONJ
gs-4132	355	45	systemic	systemic	ADJ
gs-4132	355	46	clearance	clearance	NOUN
gs-4132	355	47	by	by	ADP
gs-4132	355	48	the	the	DET
gs-4132	355	49	mononuclear	mononuclear	ADJ
gs-4132	355	50	phagocyte	phagocyte	NOUN
gs-4132	355	51	system	system	NOUN
gs-4132	355	52	.	.	PUNCT
gs-4132	356	1	immunogenicity	immunogenicity	NOUN
gs-4132	356	2	remains	remain	VERB
gs-4132	356	3	a	a	DET
gs-4132	356	4	central	central	ADJ
gs-4132	356	5	consideration	consideration	NOUN
gs-4132	356	6	in	in	ADP
gs-4132	356	7	therapeutic	therapeutic	ADJ
gs-4132	356	8	design	design	NOUN
gs-4132	356	9	.	.	PUNCT
gs-4132	357	1	exosomes	exosome	NOUN
gs-4132	357	2	generally	generally	ADV
gs-4132	357	3	demonstrate	demonstrate	VERB
gs-4132	357	4	low	low	ADJ
gs-4132	357	5	immunogenicity	immunogenicity	NOUN
gs-4132	357	6	due	due	ADP
gs-4132	357	7	to	to	ADP
gs-4132	357	8	their	their	PRON
gs-4132	357	9	endogenous	endogenous	ADJ
gs-4132	357	10	origin	origin	NOUN
gs-4132	357	11	,	,	PUNCT
gs-4132	357	12	yet	yet	CCONJ
gs-4132	357	13	the	the	DET
gs-4132	357	14	immunological	immunological	ADJ
gs-4132	357	15	profile	profile	NOUN
gs-4132	357	16	is	be	AUX
gs-4132	357	17	highly	highly	ADV
gs-4132	357	18	dependent	dependent	ADJ
gs-4132	357	19	on	on	ADP
gs-4132	357	20	the	the	DET
gs-4132	357	21	donor	donor	NOUN
gs-4132	357	22	cell	cell	NOUN
gs-4132	357	23	type	type	NOUN
gs-4132	357	24	and	and	CCONJ
gs-4132	357	25	the	the	DET
gs-4132	357	26	presence	presence	NOUN
gs-4132	357	27	of	of	ADP
gs-4132	357	28	immunomodulatory	immunomodulatory	ADJ
gs-4132	357	29	or	or	CCONJ
gs-4132	357	30	pro	pro	ADJ
gs-4132	357	31	-	-	ADJ
gs-4132	357	32	inflammatory	inflammatory	ADJ
gs-4132	357	33	cargo	cargo	NOUN
gs-4132	357	34	.	.	PUNCT
gs-4132	358	1	tumor	tumor	NOUN
gs-4132	358	2	-	-	PUNCT
gs-4132	358	3	derived	derive	VERB
gs-4132	358	4	exosomes	exosome	NOUN
gs-4132	358	5	,	,	PUNCT
gs-4132	358	6	for	for	ADP
gs-4132	358	7	instance	instance	NOUN
gs-4132	358	8	,	,	PUNCT
gs-4132	358	9	can	can	AUX
gs-4132	358	10	suppress	suppress	VERB
gs-4132	358	11	antitumor	antitumor	PROPN
gs-4132	358	12	immune	immune	ADJ
gs-4132	358	13	responses	response	NOUN
gs-4132	358	14	,	,	PUNCT
gs-4132	358	15	whereas	whereas	SCONJ
gs-4132	358	16	immune	immune	ADJ
gs-4132	358	17	cell	cell	NOUN
gs-4132	358	18	-	-	PUNCT
gs-4132	358	19	derived	derive	VERB
gs-4132	358	20	exosomes	exosome	NOUN
gs-4132	358	21	may	may	AUX
gs-4132	358	22	enhance	enhance	VERB
gs-4132	358	23	immune	immune	ADJ
gs-4132	358	24	activation	activation	NOUN
gs-4132	358	25	and	and	CCONJ
gs-4132	358	26	antigen	antigen	NOUN
gs-4132	358	27	presentation	presentation	NOUN
gs-4132	358	28	.	.	PUNCT
gs-4132	359	1	synthetic	synthetic	ADJ
gs-4132	359	2	nanoparticles	nanoparticle	NOUN
gs-4132	359	3	,	,	PUNCT
gs-4132	359	4	conversely	conversely	ADV
gs-4132	359	5	,	,	PUNCT
gs-4132	359	6	often	often	ADV
gs-4132	359	7	provoke	provoke	VERB
gs-4132	359	8	immune	immune	ADJ
gs-4132	359	9	recognition	recognition	NOUN
gs-4132	359	10	,	,	PUNCT
gs-4132	359	11	including	include	VERB
gs-4132	359	12	complement	complement	NOUN
gs-4132	359	13	activation	activation	NOUN
gs-4132	359	14	and	and	CCONJ
gs-4132	359	15	cytokine	cytokine	NOUN
gs-4132	359	16	release	release	NOUN
gs-4132	359	17	,	,	PUNCT
gs-4132	359	18	which	which	PRON
gs-4132	359	19	can	can	AUX
gs-4132	359	20	limit	limit	VERB
gs-4132	359	21	circulation	circulation	NOUN
gs-4132	359	22	time	time	NOUN
gs-4132	359	23	and	and	CCONJ
gs-4132	359	24	therapeutic	therapeutic	ADJ
gs-4132	359	25	efficacy	efficacy	NOUN
gs-4132	359	26	.	.	PUNCT
gs-4132	360	1	surface	surface	NOUN
gs-4132	360	2	modifications	modification	NOUN
gs-4132	360	3	such	such	ADJ
gs-4132	360	4	as	as	ADP
gs-4132	360	5	pegylation	pegylation	NOUN
gs-4132	360	6	and	and	CCONJ
gs-4132	360	7	stealth	stealth	ADJ
gs-4132	360	8	coatings	coating	NOUN
gs-4132	360	9	can	can	AUX
gs-4132	360	10	mitigate	mitigate	VERB
gs-4132	360	11	these	these	DET
gs-4132	360	12	effects	effect	NOUN
gs-4132	360	13	,	,	PUNCT
gs-4132	360	14	yet	yet	CCONJ
gs-4132	360	15	these	these	DET
gs-4132	360	16	modifications	modification	NOUN
gs-4132	360	17	may	may	AUX
gs-4132	360	18	also	also	ADV
gs-4132	360	19	hinder	hinder	VERB
gs-4132	360	20	cellular	cellular	ADJ
gs-4132	360	21	uptake	uptake	NOUN
gs-4132	360	22	or	or	CCONJ
gs-4132	360	23	interfere	interfere	VERB
gs-4132	360	24	with	with	ADP
gs-4132	360	25	receptor	receptor	NOUN
gs-4132	360	26	-	-	PUNCT
gs-4132	360	27	mediated	mediate	VERB
gs-4132	360	28	targeting	targeting	NOUN
gs-4132	360	29	,	,	PUNCT
gs-4132	360	30	highlighting	highlight	VERB
gs-4132	360	31	a	a	DET
gs-4132	360	32	delicate	delicate	ADJ
gs-4132	360	33	balance	balance	NOUN
gs-4132	360	34	in	in	ADP
gs-4132	360	35	synthetic	synthetic	ADJ
gs-4132	360	36	nanocarrier	nanocarrier	NOUN
gs-4132	360	37	design	design	NOUN
gs-4132	360	38	.	.	PUNCT
gs-4132	361	1	therapeutic	therapeutic	ADJ
gs-4132	361	2	applications	application	NOUN
gs-4132	361	3	of	of	ADP
gs-4132	361	4	exosomes	exosome	NOUN
gs-4132	361	5	extend	extend	VERB
gs-4132	361	6	beyond	beyond	ADP
gs-4132	361	7	traditional	traditional	ADJ
gs-4132	361	8	drug	drug	NOUN
gs-4132	361	9	delivery	delivery	NOUN
gs-4132	361	10	,	,	PUNCT
gs-4132	361	11	encompassing	encompass	VERB
gs-4132	361	12	gene	gene	NOUN
gs-4132	361	13	therapy	therapy	NOUN
gs-4132	361	14	,	,	PUNCT
gs-4132	361	15	immunotherapy	immunotherapy	NOUN
gs-4132	361	16	,	,	PUNCT
gs-4132	361	17	and	and	CCONJ
gs-4132	361	18	regenerative	regenerative	ADJ
gs-4132	361	19	medicine	medicine	NOUN
gs-4132	361	20	.	.	PUNCT
gs-4132	362	1	exosomes	exosome	NOUN
gs-4132	362	2	can	can	AUX
gs-4132	362	3	carry	carry	VERB
gs-4132	362	4	small	small	ADJ
gs-4132	362	5	interfering	interfere	VERB
gs-4132	362	6	rnas	rna	NOUN
gs-4132	362	7	(	(	PUNCT
gs-4132	362	8	sirnas	sirnas	PROPN
gs-4132	362	9	)	)	PUNCT
gs-4132	362	10	,	,	PUNCT
gs-4132	362	11	micrornas	microrna	NOUN
gs-4132	362	12	,	,	PUNCT
gs-4132	362	13	messenger	messenger	NOUN
gs-4132	362	14	rnas	rna	NOUN
gs-4132	362	15	,	,	PUNCT
gs-4132	362	16	and	and	CCONJ
gs-4132	362	17	even	even	ADV
gs-4132	362	18	crispr	crispr	ADJ
gs-4132	362	19	-	-	PUNCT
gs-4132	362	20	cas	cas	NOUN
gs-4132	362	21	components	component	NOUN
gs-4132	362	22	,	,	PUNCT
gs-4132	362	23	enabling	enable	VERB
gs-4132	362	24	modulation	modulation	NOUN
gs-4132	362	25	of	of	ADP
gs-4132	362	26	gene	gene	NOUN
gs-4132	362	27	expression	expression	NOUN
gs-4132	362	28	in	in	ADP
gs-4132	362	29	target	target	NOUN
gs-4132	362	30	cells	cell	NOUN
gs-4132	362	31	.	.	PUNCT
gs-4132	363	1	for	for	ADP
gs-4132	363	2	instance	instance	NOUN
gs-4132	363	3	,	,	PUNCT
gs-4132	363	4	exosomes	exosome	NOUN
gs-4132	363	5	loaded	load	VERB
gs-4132	363	6	with	with	ADP
gs-4132	363	7	tumor	tumor	NOUN
gs-4132	363	8	-	-	PUNCT
gs-4132	363	9	suppressive	suppressive	NOUN
gs-4132	363	10	mirnas	mirna	NOUN
gs-4132	363	11	have	have	AUX
gs-4132	363	12	demonstrated	demonstrate	VERB
gs-4132	363	13	the	the	DET
gs-4132	363	14	capacity	capacity	NOUN
gs-4132	363	15	to	to	PART
gs-4132	363	16	inhibit	inhibit	VERB
gs-4132	363	17	oncogenic	oncogenic	ADJ
gs-4132	363	18	pathways	pathway	NOUN
gs-4132	363	19	in	in	ADP
gs-4132	363	20	preclinical	preclinical	ADJ
gs-4132	363	21	cancer	cancer	NOUN
gs-4132	363	22	models	model	NOUN
gs-4132	363	23	,	,	PUNCT
gs-4132	363	24	while	while	SCONJ
gs-4132	363	25	exosomes	exosome	NOUN
gs-4132	363	26	carrying	carry	VERB
gs-4132	363	27	neuroprotective	neuroprotective	ADJ
gs-4132	363	28	rnas	rna	NOUN
gs-4132	363	29	have	have	AUX
gs-4132	363	30	shown	show	VERB
gs-4132	363	31	promise	promise	NOUN
gs-4132	363	32	in	in	ADP
gs-4132	363	33	mitigating	mitigate	VERB
gs-4132	363	34	neuronal	neuronal	ADJ
gs-4132	363	35	injury	injury	NOUN
gs-4132	363	36	and	and	CCONJ
gs-4132	363	37	neurodegeneration	neurodegeneration	NOUN
gs-4132	363	38	.	.	PUNCT
gs-4132	364	1	in	in	ADP
gs-4132	364	2	regenerative	regenerative	ADJ
gs-4132	364	3	medicine	medicine	NOUN
gs-4132	364	4	,	,	PUNCT
gs-4132	364	5	exosomes	exosome	NOUN
gs-4132	364	6	derived	derive	VERB
gs-4132	364	7	from	from	ADP
gs-4132	364	8	stem	stem	NOUN
gs-4132	364	9	cells	cell	NOUN
gs-4132	364	10	promote	promote	VERB
gs-4132	364	11	angiogenesis	angiogenesis	NOUN
gs-4132	364	12	,	,	PUNCT
gs-4132	364	13	modulate	modulate	VERB
gs-4132	364	14	inflammatory	inflammatory	ADJ
gs-4132	364	15	responses	response	NOUN
gs-4132	364	16	,	,	PUNCT
gs-4132	364	17	and	and	CCONJ
gs-4132	364	18	facilitate	facilitate	VERB
gs-4132	364	19	tissue	tissue	NOUN
gs-4132	364	20	repair	repair	NOUN
gs-4132	364	21	,	,	PUNCT
gs-4132	364	22	highlighting	highlight	VERB
gs-4132	364	23	their	their	PRON
gs-4132	364	24	dual	dual	ADJ
gs-4132	364	25	role	role	NOUN
gs-4132	364	26	as	as	ADP
gs-4132	364	27	both	both	DET
gs-4132	364	28	carriers	carrier	NOUN
gs-4132	364	29	and	and	CCONJ
gs-4132	364	30	active	active	ADJ
gs-4132	364	31	therapeutic	therapeutic	ADJ
gs-4132	364	32	agents	agent	NOUN
gs-4132	364	33	.	.	PUNCT
gs-4132	365	1	the	the	DET
gs-4132	365	2	ability	ability	NOUN
gs-4132	365	3	to	to	PART
gs-4132	365	4	combine	combine	VERB
gs-4132	365	5	exogenous	exogenous	ADJ
gs-4132	365	6	cargo	cargo	NOUN
gs-4132	365	7	with	with	ADP
gs-4132	365	8	intrinsic	intrinsic	ADJ
gs-4132	365	9	bioactivity	bioactivity	NOUN
gs-4132	365	10	positions	position	NOUN
gs-4132	365	11	exosomes	exosome	NOUN
gs-4132	365	12	as	as	ADP
gs-4132	365	13	a	a	DET
gs-4132	365	14	uniquely	uniquely	ADV
gs-4132	365	15	versatile	versatile	ADJ
gs-4132	365	16	platform	platform	NOUN
gs-4132	365	17	capable	capable	ADJ
gs-4132	365	18	of	of	ADP
gs-4132	365	19	addressing	address	VERB
gs-4132	365	20	multifactorial	multifactorial	ADJ
gs-4132	365	21	disease	disease	NOUN
gs-4132	365	22	mechanisms	mechanism	NOUN
gs-4132	365	23	.	.	PUNCT
gs-4132	366	1	synthetic	synthetic	ADJ
gs-4132	366	2	nanocarriers	nanocarrier	NOUN
gs-4132	366	3	,	,	PUNCT
gs-4132	366	4	while	while	SCONJ
gs-4132	366	5	lacking	lack	VERB
gs-4132	366	6	endogenous	endogenous	ADJ
gs-4132	366	7	bioactivity	bioactivity	NOUN
gs-4132	366	8	,	,	PUNCT
gs-4132	366	9	excel	excel	VERB
gs-4132	366	10	in	in	ADP
gs-4132	366	11	versatility	versatility	NOUN
gs-4132	366	12	and	and	CCONJ
gs-4132	366	13	multifunctionality	multifunctionality	NOUN
gs-4132	366	14	.	.	PUNCT
gs-4132	367	1	liposomes	liposome	NOUN
gs-4132	367	2	,	,	PUNCT
gs-4132	367	3	for	for	ADP
gs-4132	367	4	example	example	NOUN
gs-4132	367	5	,	,	PUNCT
gs-4132	367	6	can	can	AUX
gs-4132	367	7	encapsulate	encapsulate	VERB
gs-4132	367	8	hydrophilic	hydrophilic	ADJ
gs-4132	367	9	drugs	drug	NOUN
gs-4132	367	10	in	in	ADP
gs-4132	367	11	their	their	PRON
gs-4132	367	12	aqueous	aqueous	ADJ
gs-4132	367	13	core	core	NOUN
gs-4132	367	14	and	and	CCONJ
gs-4132	367	15	hydrophobic	hydrophobic	NOUN
gs-4132	367	16	drugs	drug	NOUN
gs-4132	367	17	within	within	ADP
gs-4132	367	18	the	the	DET
gs-4132	367	19	lipid	lipid	NOUN
gs-4132	367	20	bilayer	bilayer	NOUN
gs-4132	367	21	,	,	PUNCT
gs-4132	367	22	providing	provide	VERB
gs-4132	367	23	broad	broad	ADJ
gs-4132	367	24	compatibility	compatibility	NOUN
gs-4132	367	25	with	with	ADP
gs-4132	367	26	diverse	diverse	ADJ
gs-4132	367	27	therapeutic	therapeutic	ADJ
gs-4132	367	28	molecules	molecule	NOUN
gs-4132	367	29	.	.	PUNCT
gs-4132	368	1	polymeric	polymeric	ADJ
gs-4132	368	2	nanoparticles	nanoparticle	NOUN
gs-4132	368	3	offer	offer	VERB
gs-4132	368	4	controlled	control	VERB
gs-4132	368	5	release	release	NOUN
gs-4132	368	6	profiles	profile	NOUN
gs-4132	368	7	,	,	PUNCT
gs-4132	368	8	essential	essential	ADJ
gs-4132	368	9	for	for	ADP
gs-4132	368	10	maintaining	maintain	VERB
gs-4132	368	11	therapeutic	therapeutic	ADJ
gs-4132	368	12	concentrations	concentration	NOUN
gs-4132	368	13	over	over	ADP
gs-4132	368	14	extended	extended	ADJ
gs-4132	368	15	periods	period	NOUN
gs-4132	368	16	,	,	PUNCT
gs-4132	368	17	while	while	SCONJ
gs-4132	368	18	dendrimers	dendrimer	NOUN
gs-4132	368	19	and	and	CCONJ
gs-4132	368	20	micelles	micelle	VERB
gs-4132	368	21	georgian	georgian	NOUN
gs-4132	368	22	scientists/	scientists/	NUM
gs-4132	368	23	.	.	PUNCT
gs-4132	369	1	7	7	NUM
gs-4132	369	2	n	n	DET
gs-4132	369	3	4	4	NUM
gs-4132	369	4	,	,	PUNCT
gs-4132	369	5	2025	2025	NUM
gs-4132	369	6	23	23	NUM
gs-4132	369	7	enable	enable	VERB
gs-4132	369	8	co	co	NOUN
gs-4132	369	9	-	-	NOUN
gs-4132	369	10	delivery	delivery	NOUN
gs-4132	369	11	of	of	ADP
gs-4132	369	12	synergistic	synergistic	ADJ
gs-4132	369	13	drug	drug	NOUN
gs-4132	369	14	combinations	combination	NOUN
gs-4132	369	15	.	.	PUNCT
gs-4132	370	1	inorganic	inorganic	ADJ
gs-4132	370	2	nanoparticles	nanoparticle	NOUN
gs-4132	370	3	introduce	introduce	VERB
gs-4132	370	4	additional	additional	ADJ
gs-4132	370	5	functionalities	functionality	NOUN
gs-4132	370	6	,	,	PUNCT
gs-4132	370	7	such	such	ADJ
gs-4132	370	8	as	as	ADP
gs-4132	370	9	imaging	imaging	NOUN
gs-4132	370	10	contrast	contrast	NOUN
gs-4132	370	11	,	,	PUNCT
gs-4132	370	12	photothermal	photothermal	ADJ
gs-4132	370	13	properties	property	NOUN
gs-4132	370	14	,	,	PUNCT
gs-4132	370	15	or	or	CCONJ
gs-4132	370	16	magnetic	magnetic	ADJ
gs-4132	370	17	guidance	guidance	NOUN
gs-4132	370	18	,	,	PUNCT
gs-4132	370	19	creating	create	VERB
gs-4132	370	20	opportunities	opportunity	NOUN
gs-4132	370	21	for	for	ADP
gs-4132	370	22	integrated	integrate	VERB
gs-4132	370	23	theranostic	theranostic	ADJ
gs-4132	370	24	applications	application	NOUN
gs-4132	370	25	.	.	PUNCT
gs-4132	371	1	this	this	DET
gs-4132	371	2	multifunctionality	multifunctionality	NOUN
gs-4132	371	3	has	have	AUX
gs-4132	371	4	enabled	enable	VERB
gs-4132	371	5	synthetic	synthetic	ADJ
gs-4132	371	6	nanocarriers	nanocarrier	NOUN
gs-4132	371	7	to	to	PART
gs-4132	371	8	become	become	VERB
gs-4132	371	9	a	a	DET
gs-4132	371	10	cornerstone	cornerstone	NOUN
gs-4132	371	11	of	of	ADP
gs-4132	371	12	contemporary	contemporary	ADJ
gs-4132	371	13	drug	drug	NOUN
gs-4132	371	14	delivery	delivery	NOUN
gs-4132	371	15	,	,	PUNCT
gs-4132	371	16	exemplified	exemplify	VERB
gs-4132	371	17	by	by	ADP
gs-4132	371	18	the	the	DET
gs-4132	371	19	rapid	rapid	ADJ
gs-4132	371	20	development	development	NOUN
gs-4132	371	21	and	and	CCONJ
gs-4132	371	22	deployment	deployment	NOUN
gs-4132	371	23	of	of	ADP
gs-4132	371	24	mrna	mrna	PROPN
gs-4132	371	25	vaccines	vaccine	NOUN
gs-4132	371	26	for	for	ADP
gs-4132	371	27	infectious	infectious	ADJ
gs-4132	371	28	diseases	disease	NOUN
gs-4132	371	29	,	,	PUNCT
gs-4132	371	30	which	which	PRON
gs-4132	371	31	rely	rely	VERB
gs-4132	371	32	on	on	ADP
gs-4132	371	33	lipid	lipid	ADJ
gs-4132	371	34	nanoparticles	nanoparticle	NOUN
gs-4132	371	35	to	to	PART
gs-4132	371	36	protect	protect	VERB
gs-4132	371	37	and	and	CCONJ
gs-4132	371	38	deliver	deliver	VERB
gs-4132	371	39	genetic	genetic	ADJ
gs-4132	371	40	cargo	cargo	NOUN
gs-4132	371	41	with	with	ADP
gs-4132	371	42	high	high	ADJ
gs-4132	371	43	efficiency	efficiency	NOUN
gs-4132	371	44	.	.	PUNCT
gs-4132	372	1	hybrid	hybrid	ADJ
gs-4132	372	2	systems	system	NOUN
gs-4132	372	3	that	that	PRON
gs-4132	372	4	combine	combine	VERB
gs-4132	372	5	the	the	DET
gs-4132	372	6	strengths	strength	NOUN
gs-4132	372	7	of	of	ADP
gs-4132	372	8	exosomes	exosome	NOUN
gs-4132	372	9	and	and	CCONJ
gs-4132	372	10	synthetic	synthetic	ADJ
gs-4132	372	11	nanoparticles	nanoparticle	NOUN
gs-4132	372	12	represent	represent	VERB
gs-4132	372	13	a	a	DET
gs-4132	372	14	rapidly	rapidly	ADV
gs-4132	372	15	emerging	emerge	VERB
gs-4132	372	16	frontier	frontier	NOUN
gs-4132	372	17	.	.	PUNCT
gs-4132	373	1	exosome	exosome	VERB
gs-4132	373	2	-	-	PUNCT
gs-4132	373	3	mimetic	mimetic	ADJ
gs-4132	373	4	vesicles	vesicle	NOUN
gs-4132	373	5	,	,	PUNCT
gs-4132	373	6	where	where	SCONJ
gs-4132	373	7	natural	natural	ADJ
gs-4132	373	8	membranes	membrane	NOUN
gs-4132	373	9	are	be	AUX
gs-4132	373	10	fused	fuse	VERB
gs-4132	373	11	with	with	ADP
gs-4132	373	12	synthetic	synthetic	ADJ
gs-4132	373	13	cores	core	NOUN
gs-4132	373	14	,	,	PUNCT
gs-4132	373	15	offer	offer	VERB
gs-4132	373	16	enhanced	enhance	VERB
gs-4132	373	17	loading	loading	NOUN
gs-4132	373	18	capacity	capacity	NOUN
gs-4132	373	19	while	while	SCONJ
gs-4132	373	20	preserving	preserve	VERB
gs-4132	373	21	the	the	DET
gs-4132	373	22	targeting	targeting	NOUN
gs-4132	373	23	and	and	CCONJ
gs-4132	373	24	biocompatibility	biocompatibility	NOUN
gs-4132	373	25	of	of	ADP
gs-4132	373	26	native	native	ADJ
gs-4132	373	27	exosomes	exosome	NOUN
gs-4132	373	28	.	.	PUNCT
gs-4132	374	1	such	such	ADJ
gs-4132	374	2	systems	system	NOUN
gs-4132	374	3	allow	allow	VERB
gs-4132	374	4	for	for	ADP
gs-4132	374	5	the	the	DET
gs-4132	374	6	co	co	NOUN
gs-4132	374	7	-	-	NOUN
gs-4132	374	8	delivery	delivery	NOUN
gs-4132	374	9	of	of	ADP
gs-4132	374	10	multiple	multiple	ADJ
gs-4132	374	11	payloads	payload	NOUN
gs-4132	374	12	,	,	PUNCT
gs-4132	374	13	precise	precise	ADJ
gs-4132	374	14	control	control	NOUN
gs-4132	374	15	over	over	ADP
gs-4132	374	16	release	release	NOUN
gs-4132	374	17	kinetics	kinetic	NOUN
gs-4132	374	18	,	,	PUNCT
gs-4132	374	19	and	and	CCONJ
gs-4132	374	20	the	the	DET
gs-4132	374	21	integration	integration	NOUN
gs-4132	374	22	of	of	ADP
gs-4132	374	23	imaging	imaging	NOUN
gs-4132	374	24	or	or	CCONJ
gs-4132	374	25	diagnostic	diagnostic	ADJ
gs-4132	374	26	functionalities	functionality	NOUN
gs-4132	374	27	.	.	PUNCT
gs-4132	375	1	surface	surface	NOUN
gs-4132	375	2	engineering	engineering	NOUN
gs-4132	375	3	of	of	ADP
gs-4132	375	4	exosomes	exosome	NOUN
gs-4132	375	5	with	with	ADP
gs-4132	375	6	polymers	polymer	NOUN
gs-4132	375	7	or	or	CCONJ
gs-4132	375	8	ligands	ligand	NOUN
gs-4132	375	9	further	far	ADV
gs-4132	375	10	extends	extend	VERB
gs-4132	375	11	their	their	PRON
gs-4132	375	12	functional	functional	ADJ
gs-4132	375	13	versatility	versatility	NOUN
gs-4132	375	14	,	,	PUNCT
gs-4132	375	15	enabling	enable	VERB
gs-4132	375	16	prolonged	prolonged	ADJ
gs-4132	375	17	circulation	circulation	NOUN
gs-4132	375	18	,	,	PUNCT
gs-4132	375	19	targeted	target	VERB
gs-4132	375	20	delivery	delivery	NOUN
gs-4132	375	21	,	,	PUNCT
gs-4132	375	22	and	and	CCONJ
gs-4132	375	23	controlled	control	VERB
gs-4132	375	24	release	release	NOUN
gs-4132	375	25	,	,	PUNCT
gs-4132	375	26	while	while	SCONJ
gs-4132	375	27	retaining	retain	VERB
gs-4132	375	28	the	the	DET
gs-4132	375	29	biological	biological	ADJ
gs-4132	375	30	recognition	recognition	NOUN
gs-4132	375	31	features	feature	VERB
gs-4132	375	32	intrinsic	intrinsic	ADJ
gs-4132	375	33	to	to	ADP
gs-4132	375	34	exosomes	exosome	NOUN
gs-4132	375	35	.	.	PUNCT
gs-4132	376	1	these	these	DET
gs-4132	376	2	hybrid	hybrid	ADJ
gs-4132	376	3	approaches	approach	NOUN
gs-4132	376	4	exemplify	exemplify	VERB
gs-4132	376	5	the	the	DET
gs-4132	376	6	convergence	convergence	NOUN
gs-4132	376	7	of	of	ADP
gs-4132	376	8	biology	biology	NOUN
gs-4132	376	9	and	and	CCONJ
gs-4132	376	10	engineering	engineering	NOUN
gs-4132	376	11	in	in	ADP
gs-4132	376	12	the	the	DET
gs-4132	376	13	pursuit	pursuit	NOUN
gs-4132	376	14	of	of	ADP
gs-4132	376	15	optimized	optimize	VERB
gs-4132	376	16	nanotherapeutics	nanotherapeutic	NOUN
gs-4132	376	17	.	.	PUNCT
gs-4132	377	1	analytical	analytical	ADJ
gs-4132	377	2	and	and	CCONJ
gs-4132	377	3	characterization	characterization	NOUN
gs-4132	377	4	methods	method	NOUN
gs-4132	377	5	are	be	AUX
gs-4132	377	6	essential	essential	ADJ
gs-4132	377	7	for	for	ADP
gs-4132	377	8	understanding	understand	VERB
gs-4132	377	9	the	the	DET
gs-4132	377	10	properties	property	NOUN
gs-4132	377	11	,	,	PUNCT
gs-4132	377	12	behavior	behavior	NOUN
gs-4132	377	13	,	,	PUNCT
gs-4132	377	14	and	and	CCONJ
gs-4132	377	15	therapeutic	therapeutic	ADJ
gs-4132	377	16	potential	potential	NOUN
gs-4132	377	17	of	of	ADP
gs-4132	377	18	both	both	DET
gs-4132	377	19	exosomes	exosome	NOUN
gs-4132	377	20	and	and	CCONJ
gs-4132	377	21	synthetic	synthetic	ADJ
gs-4132	377	22	nanocarriers	nanocarrier	NOUN
gs-4132	377	23	.	.	PUNCT
gs-4132	378	1	techniques	technique	NOUN
gs-4132	378	2	such	such	ADJ
gs-4132	378	3	as	as	ADP
gs-4132	378	4	nanoparticle	nanoparticle	NOUN
gs-4132	378	5	tracking	track	VERB
gs-4132	378	6	analysis	analysis	NOUN
gs-4132	378	7	,	,	PUNCT
gs-4132	378	8	dynamic	dynamic	ADJ
gs-4132	378	9	light	light	NOUN
gs-4132	378	10	scattering	scattering	NOUN
gs-4132	378	11	,	,	PUNCT
gs-4132	378	12	flow	flow	NOUN
gs-4132	378	13	cytometry	cytometry	NOUN
gs-4132	378	14	,	,	PUNCT
gs-4132	378	15	and	and	CCONJ
gs-4132	378	16	electron	electron	NOUN
gs-4132	378	17	microscopy	microscopy	NOUN
gs-4132	378	18	allow	allow	VERB
gs-4132	378	19	for	for	ADP
gs-4132	378	20	detailed	detailed	ADJ
gs-4132	378	21	assessment	assessment	NOUN
gs-4132	378	22	of	of	ADP
gs-4132	378	23	size	size	NOUN
gs-4132	378	24	distribution	distribution	NOUN
gs-4132	378	25	,	,	PUNCT
gs-4132	378	26	surface	surface	NOUN
gs-4132	378	27	morphology	morphology	NOUN
gs-4132	378	28	,	,	PUNCT
gs-4132	378	29	and	and	CCONJ
gs-4132	378	30	concentration	concentration	NOUN
gs-4132	378	31	.	.	PUNCT
gs-4132	379	1	high	high	ADJ
gs-4132	379	2	-	-	PUNCT
gs-4132	379	3	resolution	resolution	NOUN
gs-4132	379	4	omics	omic	NOUN
gs-4132	379	5	approaches	approach	NOUN
gs-4132	379	6	,	,	PUNCT
gs-4132	379	7	including	include	VERB
gs-4132	379	8	proteomics	proteomic	NOUN
gs-4132	379	9	,	,	PUNCT
gs-4132	379	10	lipidomics	lipidomic	NOUN
gs-4132	379	11	,	,	PUNCT
gs-4132	379	12	and	and	CCONJ
gs-4132	379	13	transcriptomics	transcriptomic	NOUN
gs-4132	379	14	,	,	PUNCT
gs-4132	379	15	provide	provide	VERB
gs-4132	379	16	comprehensive	comprehensive	ADJ
gs-4132	379	17	profiling	profiling	NOUN
gs-4132	379	18	of	of	ADP
gs-4132	379	19	exosomal	exosomal	ADJ
gs-4132	379	20	cargo	cargo	NOUN
gs-4132	379	21	,	,	PUNCT
gs-4132	379	22	enabling	enable	VERB
gs-4132	379	23	identification	identification	NOUN
gs-4132	379	24	of	of	ADP
gs-4132	379	25	functional	functional	ADJ
gs-4132	379	26	molecules	molecule	NOUN
gs-4132	379	27	and	and	CCONJ
gs-4132	379	28	optimization	optimization	NOUN
gs-4132	379	29	of	of	ADP
gs-4132	379	30	therapeutic	therapeutic	ADJ
gs-4132	379	31	design	design	NOUN
gs-4132	379	32	.	.	PUNCT
gs-4132	380	1	for	for	ADP
gs-4132	380	2	synthetic	synthetic	ADJ
gs-4132	380	3	nanoparticles	nanoparticle	NOUN
gs-4132	380	4	,	,	PUNCT
gs-4132	380	5	physicochemical	physicochemical	ADJ
gs-4132	380	6	characterization	characterization	NOUN
gs-4132	380	7	through	through	ADP
gs-4132	380	8	zeta	zeta	PROPN
gs-4132	380	9	potential	potential	ADJ
gs-4132	380	10	measurement	measurement	NOUN
gs-4132	380	11	,	,	PUNCT
gs-4132	380	12	nuclear	nuclear	ADJ
gs-4132	380	13	magnetic	magnetic	ADJ
gs-4132	380	14	resonance	resonance	NOUN
gs-4132	380	15	,	,	PUNCT
gs-4132	380	16	spectroscopy	spectroscopy	NOUN
gs-4132	380	17	,	,	PUNCT
gs-4132	380	18	and	and	CCONJ
gs-4132	380	19	imaging	imaging	NOUN
gs-4132	380	20	informs	inform	VERB
gs-4132	380	21	stability	stability	NOUN
gs-4132	380	22	,	,	PUNCT
gs-4132	380	23	surface	surface	NOUN
gs-4132	380	24	chemistry	chemistry	NOUN
gs-4132	380	25	,	,	PUNCT
gs-4132	380	26	and	and	CCONJ
gs-4132	380	27	interaction	interaction	NOUN
gs-4132	380	28	with	with	ADP
gs-4132	380	29	biological	biological	ADJ
gs-4132	380	30	systems	system	NOUN
gs-4132	380	31	.	.	PUNCT
gs-4132	381	1	standardization	standardization	NOUN
gs-4132	381	2	of	of	ADP
gs-4132	381	3	these	these	DET
gs-4132	381	4	methods	method	NOUN
gs-4132	381	5	is	be	AUX
gs-4132	381	6	crucial	crucial	ADJ
gs-4132	381	7	to	to	PART
gs-4132	381	8	ensure	ensure	VERB
gs-4132	381	9	reproducibility	reproducibility	NOUN
gs-4132	381	10	,	,	PUNCT
gs-4132	381	11	regulatory	regulatory	ADJ
gs-4132	381	12	compliance	compliance	NOUN
gs-4132	381	13	,	,	PUNCT
gs-4132	381	14	and	and	CCONJ
gs-4132	381	15	successful	successful	ADJ
gs-4132	381	16	clinical	clinical	ADJ
gs-4132	381	17	translation	translation	NOUN
gs-4132	381	18	.	.	PUNCT
gs-4132	382	1	the	the	DET
gs-4132	382	2	translational	translational	ADJ
gs-4132	382	3	landscape	landscape	NOUN
gs-4132	382	4	for	for	ADP
gs-4132	382	5	exosomeand	exosomeand	NOUN
gs-4132	382	6	nanoparticle	nanoparticle	NOUN
gs-4132	382	7	-	-	PUNCT
gs-4132	382	8	based	base	VERB
gs-4132	382	9	therapeutics	therapeutic	NOUN
gs-4132	382	10	continues	continue	VERB
gs-4132	382	11	to	to	PART
gs-4132	382	12	expand	expand	VERB
gs-4132	382	13	,	,	PUNCT
gs-4132	382	14	with	with	ADP
gs-4132	382	15	clinical	clinical	ADJ
gs-4132	382	16	trials	trial	NOUN
gs-4132	382	17	exploring	explore	VERB
gs-4132	382	18	a	a	DET
gs-4132	382	19	wide	wide	ADJ
gs-4132	382	20	range	range	NOUN
gs-4132	382	21	of	of	ADP
gs-4132	382	22	indications	indication	NOUN
gs-4132	382	23	.	.	PUNCT
gs-4132	383	1	exosomes	exosome	NOUN
gs-4132	383	2	have	have	AUX
gs-4132	383	3	been	be	AUX
gs-4132	383	4	investigated	investigate	VERB
gs-4132	383	5	for	for	ADP
gs-4132	383	6	their	their	PRON
gs-4132	383	7	potential	potential	NOUN
gs-4132	383	8	in	in	ADP
gs-4132	383	9	cancer	cancer	NOUN
gs-4132	383	10	immunotherapy	immunotherapy	NOUN
gs-4132	383	11	,	,	PUNCT
gs-4132	383	12	neurological	neurological	ADJ
gs-4132	383	13	disorders	disorder	NOUN
gs-4132	383	14	,	,	PUNCT
gs-4132	383	15	cardiovascular	cardiovascular	ADJ
gs-4132	383	16	repair	repair	NOUN
gs-4132	383	17	,	,	PUNCT
gs-4132	383	18	and	and	CCONJ
gs-4132	383	19	autoimmune	autoimmune	ADJ
gs-4132	383	20	diseases	disease	NOUN
gs-4132	383	21	,	,	PUNCT
gs-4132	383	22	demonstrating	demonstrate	VERB
gs-4132	383	23	promising	promising	ADJ
gs-4132	383	24	preliminary	preliminary	ADJ
gs-4132	383	25	safety	safety	NOUN
gs-4132	383	26	and	and	CCONJ
gs-4132	383	27	efficacy	efficacy	NOUN
gs-4132	383	28	profiles	profile	NOUN
gs-4132	383	29	.	.	PUNCT
gs-4132	384	1	synthetic	synthetic	ADJ
gs-4132	384	2	nanoparticles	nanoparticle	NOUN
gs-4132	384	3	have	have	AUX
gs-4132	384	4	achieved	achieve	VERB
gs-4132	384	5	significant	significant	ADJ
gs-4132	384	6	clinical	clinical	ADJ
gs-4132	384	7	success	success	NOUN
gs-4132	384	8	,	,	PUNCT
gs-4132	384	9	particularly	particularly	ADV
gs-4132	384	10	in	in	ADP
gs-4132	384	11	oncology	oncology	NOUN
gs-4132	384	12	and	and	CCONJ
gs-4132	384	13	infectious	infectious	ADJ
gs-4132	384	14	disease	disease	NOUN
gs-4132	384	15	,	,	PUNCT
gs-4132	384	16	with	with	ADP
gs-4132	384	17	approved	approve	VERB
gs-4132	384	18	liposomal	liposomal	ADJ
gs-4132	384	19	chemotherapeutics	chemotherapeutic	NOUN
gs-4132	384	20	,	,	PUNCT
gs-4132	384	21	polymeric	polymeric	ADJ
gs-4132	384	22	nanoparticle	nanoparticle	NOUN
gs-4132	384	23	-	-	PUNCT
gs-4132	384	24	based	base	VERB
gs-4132	384	25	formulations	formulation	NOUN
gs-4132	384	26	,	,	PUNCT
gs-4132	384	27	and	and	CCONJ
gs-4132	384	28	lipid	lipid	NOUN
gs-4132	384	29	nanoparticle	nanoparticle	NOUN
gs-4132	384	30	-	-	PUNCT
gs-4132	384	31	based	base	VERB
gs-4132	384	32	mrna	mrna	PROPN
gs-4132	384	33	vaccines	vaccine	NOUN
gs-4132	384	34	illustrating	illustrate	VERB
gs-4132	384	35	their	their	PRON
gs-4132	384	36	transformative	transformative	ADJ
gs-4132	384	37	impact	impact	NOUN
gs-4132	384	38	.	.	PUNCT
gs-4132	385	1	despite	despite	SCONJ
gs-4132	385	2	these	these	DET
gs-4132	385	3	advances	advance	NOUN
gs-4132	385	4	,	,	PUNCT
gs-4132	385	5	challenges	challenge	NOUN
gs-4132	385	6	remain	remain	VERB
gs-4132	385	7	,	,	PUNCT
gs-4132	385	8	including	include	VERB
gs-4132	385	9	scalable	scalable	ADJ
gs-4132	385	10	production	production	NOUN
gs-4132	385	11	,	,	PUNCT
gs-4132	385	12	batch	batch	NOUN
gs-4132	385	13	-	-	PUNCT
gs-4132	385	14	to	to	ADP
gs-4132	385	15	-	-	PUNCT
gs-4132	385	16	batch	batch	NOUN
gs-4132	385	17	consistency	consistency	NOUN
gs-4132	385	18	,	,	PUNCT
gs-4132	385	19	regulatory	regulatory	ADJ
gs-4132	385	20	oversight	oversight	NOUN
gs-4132	385	21	,	,	PUNCT
gs-4132	385	22	and	and	CCONJ
gs-4132	385	23	comprehensive	comprehensive	ADJ
gs-4132	385	24	assessment	assessment	NOUN
gs-4132	385	25	of	of	ADP
gs-4132	385	26	biodistribution	biodistribution	NOUN
gs-4132	385	27	,	,	PUNCT
gs-4132	385	28	pharmacokinetics	pharmacokinetic	NOUN
gs-4132	385	29	,	,	PUNCT
gs-4132	385	30	and	and	CCONJ
gs-4132	385	31	long	long	ADJ
gs-4132	385	32	-	-	PUNCT
gs-4132	385	33	term	term	NOUN
gs-4132	385	34	safety	safety	NOUN
gs-4132	385	35	.	.	PUNCT
gs-4132	386	1	personalized	personalize	VERB
gs-4132	386	2	nanomedicine	nanomedicine	ADJ
gs-4132	386	3	approaches	approach	NOUN
gs-4132	386	4	,	,	PUNCT
gs-4132	386	5	where	where	SCONJ
gs-4132	386	6	therapeutic	therapeutic	ADJ
gs-4132	386	7	platforms	platform	NOUN
gs-4132	386	8	are	be	AUX
gs-4132	386	9	tailored	tailor	VERB
gs-4132	386	10	to	to	ADP
gs-4132	386	11	individual	individual	ADJ
gs-4132	386	12	patient	patient	ADJ
gs-4132	386	13	profiles	profile	NOUN
gs-4132	386	14	and	and	CCONJ
gs-4132	386	15	disease	disease	NOUN
gs-4132	386	16	characteristics	characteristic	NOUN
gs-4132	386	17	,	,	PUNCT
gs-4132	386	18	are	be	AUX
gs-4132	386	19	likely	likely	ADJ
gs-4132	386	20	to	to	PART
gs-4132	386	21	enhance	enhance	VERB
gs-4132	386	22	efficacy	efficacy	NOUN
gs-4132	386	23	and	and	CCONJ
gs-4132	386	24	minimize	minimize	VERB
gs-4132	386	25	adverse	adverse	ADJ
gs-4132	386	26	effects	effect	NOUN
gs-4132	386	27	,	,	PUNCT
gs-4132	386	28	representing	represent	VERB
gs-4132	386	29	the	the	DET
gs-4132	386	30	next	next	ADJ
gs-4132	386	31	frontier	frontier	NOUN
gs-4132	386	32	in	in	ADP
gs-4132	386	33	clinical	clinical	ADJ
gs-4132	386	34	translation	translation	NOUN
gs-4132	386	35	.	.	PUNCT
gs-4132	387	1	mechanistic	mechanistic	ADJ
gs-4132	387	2	insights	insight	NOUN
gs-4132	387	3	into	into	ADP
gs-4132	387	4	cellular	cellular	ADJ
gs-4132	387	5	uptake	uptake	NOUN
gs-4132	387	6	,	,	PUNCT
gs-4132	387	7	intracellular	intracellular	ADJ
gs-4132	387	8	trafficking	trafficking	NOUN
gs-4132	387	9	,	,	PUNCT
gs-4132	387	10	and	and	CCONJ
gs-4132	387	11	payload	payload	NOUN
gs-4132	387	12	release	release	NOUN
gs-4132	387	13	are	be	AUX
gs-4132	387	14	critical	critical	ADJ
gs-4132	387	15	for	for	ADP
gs-4132	387	16	optimizing	optimize	VERB
gs-4132	387	17	both	both	PRON
gs-4132	387	18	exosomal	exosomal	ADJ
gs-4132	387	19	and	and	CCONJ
gs-4132	387	20	synthetic	synthetic	ADJ
gs-4132	387	21	nanocarrier	nanocarrier	NOUN
gs-4132	387	22	therapeutics	therapeutic	NOUN
gs-4132	387	23	.	.	PUNCT
gs-4132	388	1	exosomes	exosome	NOUN
gs-4132	388	2	georgian	georgian	PROPN
gs-4132	388	3	scientists/	scientists/	NUM
gs-4132	388	4	.	.	PUNCT
gs-4132	389	1	7	7	NUM
gs-4132	389	2	n	n	DET
gs-4132	389	3	4	4	NUM
gs-4132	389	4	,	,	PUNCT
gs-4132	389	5	2025	2025	NUM
gs-4132	389	6	24	24	NUM
gs-4132	389	7	exploit	exploit	ADJ
gs-4132	389	8	natural	natural	ADJ
gs-4132	389	9	ligand	ligand	NOUN
gs-4132	389	10	-	-	PUNCT
gs-4132	389	11	receptor	receptor	NOUN
gs-4132	389	12	interactions	interaction	NOUN
gs-4132	389	13	to	to	PART
gs-4132	389	14	achieve	achieve	VERB
gs-4132	389	15	selective	selective	ADJ
gs-4132	389	16	uptake	uptake	NOUN
gs-4132	389	17	,	,	PUNCT
gs-4132	389	18	often	often	ADV
gs-4132	389	19	circumventing	circumvent	VERB
gs-4132	389	20	lysosomal	lysosomal	ADJ
gs-4132	389	21	degradation	degradation	NOUN
gs-4132	389	22	and	and	CCONJ
gs-4132	389	23	enabling	enable	VERB
gs-4132	389	24	efficient	efficient	ADJ
gs-4132	389	25	cytoplasmic	cytoplasmic	ADJ
gs-4132	389	26	delivery	delivery	NOUN
gs-4132	389	27	of	of	ADP
gs-4132	389	28	cargo	cargo	NOUN
gs-4132	389	29	.	.	PUNCT
gs-4132	390	1	synthetic	synthetic	ADJ
gs-4132	390	2	nanoparticles	nanoparticle	NOUN
gs-4132	390	3	require	require	VERB
gs-4132	390	4	careful	careful	ADJ
gs-4132	390	5	design	design	NOUN
gs-4132	390	6	to	to	PART
gs-4132	390	7	mimic	mimic	VERB
gs-4132	390	8	these	these	DET
gs-4132	390	9	advantages	advantage	NOUN
gs-4132	390	10	,	,	PUNCT
gs-4132	390	11	utilizing	utilize	VERB
gs-4132	390	12	strategies	strategy	NOUN
gs-4132	390	13	such	such	ADJ
gs-4132	390	14	as	as	ADP
gs-4132	390	15	endosomolytic	endosomolytic	ADJ
gs-4132	390	16	polymers	polymer	NOUN
gs-4132	390	17	,	,	PUNCT
gs-4132	390	18	ph	ph	ADJ
gs-4132	390	19	-	-	ADJ
gs-4132	390	20	responsive	responsive	ADJ
gs-4132	390	21	coatings	coating	NOUN
gs-4132	390	22	,	,	PUNCT
gs-4132	390	23	and	and	CCONJ
gs-4132	390	24	receptor	receptor	NOUN
gs-4132	390	25	-	-	PUNCT
gs-4132	390	26	targeted	target	VERB
gs-4132	390	27	ligands	ligand	NOUN
gs-4132	390	28	to	to	PART
gs-4132	390	29	improve	improve	VERB
gs-4132	390	30	intracellular	intracellular	ADJ
gs-4132	390	31	delivery	delivery	NOUN
gs-4132	390	32	.	.	PUNCT
gs-4132	391	1	understanding	understand	VERB
gs-4132	391	2	the	the	DET
gs-4132	391	3	intracellular	intracellular	ADJ
gs-4132	391	4	fate	fate	NOUN
gs-4132	391	5	of	of	ADP
gs-4132	391	6	delivered	deliver	VERB
gs-4132	391	7	therapeutics	therapeutic	NOUN
gs-4132	391	8	,	,	PUNCT
gs-4132	391	9	including	include	VERB
gs-4132	391	10	subcellular	subcellular	ADJ
gs-4132	391	11	localization	localization	NOUN
gs-4132	391	12	,	,	PUNCT
gs-4132	391	13	metabolic	metabolic	NOUN
gs-4132	391	14	processing	processing	NOUN
gs-4132	391	15	,	,	PUNCT
gs-4132	391	16	and	and	CCONJ
gs-4132	391	17	exocytosis	exocytosis	NOUN
gs-4132	391	18	,	,	PUNCT
gs-4132	391	19	is	be	AUX
gs-4132	391	20	essential	essential	ADJ
gs-4132	391	21	for	for	ADP
gs-4132	391	22	predicting	predict	VERB
gs-4132	391	23	therapeutic	therapeutic	ADJ
gs-4132	391	24	efficacy	efficacy	NOUN
gs-4132	391	25	and	and	CCONJ
gs-4132	391	26	minimizing	minimize	VERB
gs-4132	391	27	off	off	ADP
gs-4132	391	28	-	-	PUNCT
gs-4132	391	29	target	target	NOUN
gs-4132	391	30	effects	effect	NOUN
gs-4132	391	31	.	.	PUNCT
gs-4132	392	1	the	the	DET
gs-4132	392	2	integration	integration	NOUN
gs-4132	392	3	of	of	ADP
gs-4132	392	4	live	live	ADJ
gs-4132	392	5	-	-	PUNCT
gs-4132	392	6	cell	cell	NOUN
gs-4132	392	7	imaging	imaging	NOUN
gs-4132	392	8	,	,	PUNCT
gs-4132	392	9	single	single	ADJ
gs-4132	392	10	-	-	PUNCT
gs-4132	392	11	particle	particle	NOUN
gs-4132	392	12	tracking	tracking	NOUN
gs-4132	392	13	,	,	PUNCT
gs-4132	392	14	and	and	CCONJ
gs-4132	392	15	computational	computational	ADJ
gs-4132	392	16	modeling	modeling	NOUN
gs-4132	392	17	provides	provide	VERB
gs-4132	392	18	valuable	valuable	ADJ
gs-4132	392	19	tools	tool	NOUN
gs-4132	392	20	for	for	ADP
gs-4132	392	21	elucidating	elucidate	VERB
gs-4132	392	22	these	these	DET
gs-4132	392	23	mechanisms	mechanism	NOUN
gs-4132	392	24	and	and	CCONJ
gs-4132	392	25	guiding	guide	VERB
gs-4132	392	26	rational	rational	ADJ
gs-4132	392	27	design	design	NOUN
gs-4132	392	28	.	.	PUNCT
gs-4132	393	1	safety	safety	NOUN
gs-4132	393	2	,	,	PUNCT
gs-4132	393	3	immunogenicity	immunogenicity	NOUN
gs-4132	393	4	,	,	PUNCT
gs-4132	393	5	and	and	CCONJ
gs-4132	393	6	biocompatibility	biocompatibility	NOUN
gs-4132	393	7	remain	remain	VERB
gs-4132	393	8	central	central	ADJ
gs-4132	393	9	considerations	consideration	NOUN
gs-4132	393	10	for	for	ADP
gs-4132	393	11	therapeutic	therapeutic	ADJ
gs-4132	393	12	development	development	NOUN
gs-4132	393	13	.	.	PUNCT
gs-4132	394	1	exosomes	exosome	NOUN
gs-4132	394	2	,	,	PUNCT
gs-4132	394	3	derived	derive	VERB
gs-4132	394	4	from	from	ADP
gs-4132	394	5	autologous	autologous	ADJ
gs-4132	394	6	cells	cell	NOUN
gs-4132	394	7	,	,	PUNCT
gs-4132	394	8	generally	generally	ADV
gs-4132	394	9	exhibit	exhibit	VERB
gs-4132	394	10	minimal	minimal	ADJ
gs-4132	394	11	immune	immune	ADJ
gs-4132	394	12	activation	activation	NOUN
gs-4132	394	13	,	,	PUNCT
gs-4132	394	14	yet	yet	CCONJ
gs-4132	394	15	their	their	PRON
gs-4132	394	16	bioactive	bioactive	ADJ
gs-4132	394	17	cargo	cargo	NOUN
gs-4132	394	18	can	can	AUX
gs-4132	394	19	elicit	elicit	VERB
gs-4132	394	20	unintended	unintended	ADJ
gs-4132	394	21	effects	effect	NOUN
gs-4132	394	22	if	if	SCONJ
gs-4132	394	23	derived	derive	VERB
gs-4132	394	24	from	from	ADP
gs-4132	394	25	pathological	pathological	ADJ
gs-4132	394	26	or	or	CCONJ
gs-4132	394	27	immunogenic	immunogenic	ADJ
gs-4132	394	28	sources	source	NOUN
gs-4132	394	29	.	.	PUNCT
gs-4132	395	1	tumor	tumor	NOUN
gs-4132	395	2	-	-	PUNCT
gs-4132	395	3	derived	derive	VERB
gs-4132	395	4	exosomes	exosome	NOUN
gs-4132	395	5	may	may	AUX
gs-4132	395	6	carry	carry	VERB
gs-4132	395	7	oncogenic	oncogenic	ADJ
gs-4132	395	8	molecules	molecule	NOUN
gs-4132	395	9	,	,	PUNCT
gs-4132	395	10	while	while	SCONJ
gs-4132	395	11	immune	immune	ADJ
gs-4132	395	12	cell	cell	NOUN
gs-4132	395	13	-	-	PUNCT
gs-4132	395	14	derived	derive	VERB
gs-4132	395	15	exosomes	exosome	NOUN
gs-4132	395	16	may	may	AUX
gs-4132	395	17	trigger	trigger	VERB
gs-4132	395	18	exaggerated	exaggerated	ADJ
gs-4132	395	19	immune	immune	ADJ
gs-4132	395	20	responses	response	NOUN
gs-4132	395	21	.	.	PUNCT
gs-4132	396	1	synthetic	synthetic	ADJ
gs-4132	396	2	nanoparticles	nanoparticle	NOUN
gs-4132	396	3	,	,	PUNCT
gs-4132	396	4	particularly	particularly	ADV
gs-4132	396	5	those	those	PRON
gs-4132	396	6	with	with	ADP
gs-4132	396	7	non	non	ADJ
gs-4132	396	8	-	-	ADJ
gs-4132	396	9	biodegradable	biodegradable	ADJ
gs-4132	396	10	components	component	NOUN
gs-4132	396	11	,	,	PUNCT
gs-4132	396	12	face	face	VERB
gs-4132	396	13	potential	potential	ADJ
gs-4132	396	14	toxicity	toxicity	NOUN
gs-4132	396	15	,	,	PUNCT
gs-4132	396	16	complement	complement	NOUN
gs-4132	396	17	activation	activation	NOUN
gs-4132	396	18	,	,	PUNCT
gs-4132	396	19	and	and	CCONJ
gs-4132	396	20	systemic	systemic	ADJ
gs-4132	396	21	accumulation	accumulation	NOUN
gs-4132	396	22	.	.	PUNCT
gs-4132	397	1	strategies	strategy	NOUN
gs-4132	397	2	such	such	ADJ
gs-4132	397	3	as	as	ADP
gs-4132	397	4	surface	surface	NOUN
gs-4132	397	5	functionalization	functionalization	NOUN
gs-4132	397	6	,	,	PUNCT
gs-4132	397	7	biodegradable	biodegradable	ADJ
gs-4132	397	8	polymer	polymer	NOUN
gs-4132	397	9	selection	selection	NOUN
gs-4132	397	10	,	,	PUNCT
gs-4132	397	11	and	and	CCONJ
gs-4132	397	12	incorporation	incorporation	NOUN
gs-4132	397	13	of	of	ADP
gs-4132	397	14	endogenous	endogenous	ADJ
gs-4132	397	15	biomimetic	biomimetic	ADJ
gs-4132	397	16	components	component	NOUN
gs-4132	397	17	are	be	AUX
gs-4132	397	18	increasingly	increasingly	ADV
gs-4132	397	19	used	use	VERB
gs-4132	397	20	to	to	PART
gs-4132	397	21	mitigate	mitigate	VERB
gs-4132	397	22	these	these	DET
gs-4132	397	23	risks	risk	NOUN
gs-4132	397	24	,	,	PUNCT
gs-4132	397	25	yet	yet	CCONJ
gs-4132	397	26	long	long	ADJ
gs-4132	397	27	-	-	PUNCT
gs-4132	397	28	term	term	NOUN
gs-4132	397	29	safety	safety	NOUN
gs-4132	397	30	data	datum	NOUN
gs-4132	397	31	remain	remain	VERB
gs-4132	397	32	limited	limited	ADJ
gs-4132	397	33	.	.	PUNCT
gs-4132	398	1	comprehensive	comprehensive	ADJ
gs-4132	398	2	preclinical	preclinical	ADJ
gs-4132	398	3	studies	study	NOUN
gs-4132	398	4	,	,	PUNCT
gs-4132	398	5	coupled	couple	VERB
gs-4132	398	6	with	with	ADP
gs-4132	398	7	standardized	standardized	ADJ
gs-4132	398	8	regulatory	regulatory	ADJ
gs-4132	398	9	frameworks	framework	NOUN
gs-4132	398	10	,	,	PUNCT
gs-4132	398	11	are	be	AUX
gs-4132	398	12	essential	essential	ADJ
gs-4132	398	13	for	for	ADP
gs-4132	398	14	the	the	DET
gs-4132	398	15	responsible	responsible	ADJ
gs-4132	398	16	translation	translation	NOUN
gs-4132	398	17	of	of	ADP
gs-4132	398	18	both	both	DET
gs-4132	398	19	exosomal	exosomal	ADJ
gs-4132	398	20	and	and	CCONJ
gs-4132	398	21	synthetic	synthetic	ADJ
gs-4132	398	22	therapeutics	therapeutic	NOUN
gs-4132	398	23	.	.	PUNCT
gs-4132	399	1	the	the	DET
gs-4132	399	2	integration	integration	NOUN
gs-4132	399	3	of	of	ADP
gs-4132	399	4	computational	computational	ADJ
gs-4132	399	5	modeling	modeling	NOUN
gs-4132	399	6	,	,	PUNCT
gs-4132	399	7	artificial	artificial	ADJ
gs-4132	399	8	intelligence	intelligence	NOUN
gs-4132	399	9	,	,	PUNCT
gs-4132	399	10	and	and	CCONJ
gs-4132	399	11	high	high	ADJ
gs-4132	399	12	-	-	PUNCT
gs-4132	399	13	throughput	throughput	NOUN
gs-4132	399	14	screening	screening	NOUN
gs-4132	399	15	is	be	AUX
gs-4132	399	16	reshaping	reshape	VERB
gs-4132	399	17	the	the	DET
gs-4132	399	18	development	development	NOUN
gs-4132	399	19	of	of	ADP
gs-4132	399	20	nanotherapeutics	nanotherapeutic	NOUN
gs-4132	399	21	.	.	PUNCT
gs-4132	400	1	predictive	predictive	ADJ
gs-4132	400	2	models	model	NOUN
gs-4132	400	3	of	of	ADP
gs-4132	400	4	biodistribution	biodistribution	NOUN
gs-4132	400	5	,	,	PUNCT
gs-4132	400	6	immune	immune	ADJ
gs-4132	400	7	response	response	NOUN
gs-4132	400	8	,	,	PUNCT
gs-4132	400	9	and	and	CCONJ
gs-4132	400	10	therapeutic	therapeutic	ADJ
gs-4132	400	11	efficacy	efficacy	NOUN
gs-4132	400	12	enable	enable	VERB
gs-4132	400	13	the	the	DET
gs-4132	400	14	rational	rational	ADJ
gs-4132	400	15	design	design	NOUN
gs-4132	400	16	of	of	ADP
gs-4132	400	17	exosomes	exosome	NOUN
gs-4132	400	18	and	and	CCONJ
gs-4132	400	19	synthetic	synthetic	ADJ
gs-4132	400	20	nanocarriers	nanocarrier	NOUN
gs-4132	400	21	,	,	PUNCT
gs-4132	400	22	reducing	reduce	VERB
gs-4132	400	23	empirical	empirical	ADJ
gs-4132	400	24	experimentation	experimentation	NOUN
gs-4132	400	25	and	and	CCONJ
gs-4132	400	26	accelerating	accelerate	VERB
gs-4132	400	27	optimization	optimization	NOUN
gs-4132	400	28	.	.	PUNCT
gs-4132	401	1	machine	machine	NOUN
gs-4132	401	2	learning	learn	VERB
gs-4132	401	3	algorithms	algorithm	NOUN
gs-4132	401	4	can	can	AUX
gs-4132	401	5	identify	identify	VERB
gs-4132	401	6	patterns	pattern	NOUN
gs-4132	401	7	in	in	ADP
gs-4132	401	8	exosomal	exosomal	ADJ
gs-4132	401	9	cargo	cargo	NOUN
gs-4132	401	10	composition	composition	NOUN
gs-4132	401	11	,	,	PUNCT
gs-4132	401	12	predict	predict	VERB
gs-4132	401	13	target	target	NOUN
gs-4132	401	14	tissue	tissue	NOUN
gs-4132	401	15	tropism	tropism	NOUN
gs-4132	401	16	,	,	PUNCT
gs-4132	401	17	and	and	CCONJ
gs-4132	401	18	guide	guide	VERB
gs-4132	401	19	engineering	engineering	NOUN
gs-4132	401	20	strategies	strategy	NOUN
gs-4132	401	21	to	to	PART
gs-4132	401	22	enhance	enhance	VERB
gs-4132	401	23	specificity	specificity	NOUN
gs-4132	401	24	and	and	CCONJ
gs-4132	401	25	functional	functional	ADJ
gs-4132	401	26	delivery	delivery	NOUN
gs-4132	401	27	.	.	PUNCT
gs-4132	402	1	for	for	ADP
gs-4132	402	2	synthetic	synthetic	ADJ
gs-4132	402	3	nanoparticles	nanoparticle	NOUN
gs-4132	402	4	,	,	PUNCT
gs-4132	402	5	computational	computational	ADJ
gs-4132	402	6	tools	tool	NOUN
gs-4132	402	7	facilitate	facilitate	VERB
gs-4132	402	8	the	the	DET
gs-4132	402	9	design	design	NOUN
gs-4132	402	10	of	of	ADP
gs-4132	402	11	surface	surface	NOUN
gs-4132	402	12	ligands	ligand	NOUN
gs-4132	402	13	,	,	PUNCT
gs-4132	402	14	optimize	optimize	VERB
gs-4132	402	15	physicochemical	physicochemical	ADJ
gs-4132	402	16	properties	property	NOUN
gs-4132	402	17	,	,	PUNCT
gs-4132	402	18	and	and	CCONJ
gs-4132	402	19	predict	predict	VERB
gs-4132	402	20	interactions	interaction	NOUN
gs-4132	402	21	with	with	ADP
gs-4132	402	22	biological	biological	ADJ
gs-4132	402	23	systems	system	NOUN
gs-4132	402	24	.	.	PUNCT
gs-4132	403	1	this	this	DET
gs-4132	403	2	convergence	convergence	NOUN
gs-4132	403	3	of	of	ADP
gs-4132	403	4	data	data	NOUN
gs-4132	403	5	-	-	PUNCT
gs-4132	403	6	driven	drive	VERB
gs-4132	403	7	approaches	approach	NOUN
gs-4132	403	8	with	with	ADP
gs-4132	403	9	experimental	experimental	ADJ
gs-4132	403	10	validation	validation	NOUN
gs-4132	403	11	is	be	AUX
gs-4132	403	12	driving	drive	VERB
gs-4132	403	13	a	a	DET
gs-4132	403	14	new	new	ADJ
gs-4132	403	15	paradigm	paradigm	NOUN
gs-4132	403	16	in	in	ADP
gs-4132	403	17	nanomedicine	nanomedicine	NOUN
gs-4132	403	18	,	,	PUNCT
gs-4132	403	19	where	where	SCONJ
gs-4132	403	20	therapeutics	therapeutic	NOUN
gs-4132	403	21	are	be	AUX
gs-4132	403	22	precisely	precisely	ADV
gs-4132	403	23	tailored	tailor	VERB
gs-4132	403	24	to	to	ADP
gs-4132	403	25	disease	disease	NOUN
gs-4132	403	26	mechanisms	mechanism	NOUN
gs-4132	403	27	and	and	CCONJ
gs-4132	403	28	patient	patient	NOUN
gs-4132	403	29	-	-	PUNCT
gs-4132	403	30	specific	specific	ADJ
gs-4132	403	31	contexts	contexts	NOUN
gs-4132	403	32	.	.	PUNCT
gs-4132	404	1	future	future	ADJ
gs-4132	404	2	directions	direction	NOUN
gs-4132	404	3	in	in	ADP
gs-4132	404	4	the	the	DET
gs-4132	404	5	field	field	NOUN
gs-4132	404	6	emphasize	emphasize	VERB
gs-4132	404	7	multifunctional	multifunctional	ADJ
gs-4132	404	8	,	,	PUNCT
gs-4132	404	9	modular	modular	ADJ
gs-4132	404	10	,	,	PUNCT
gs-4132	404	11	and	and	CCONJ
gs-4132	404	12	personalized	personalized	ADJ
gs-4132	404	13	approaches	approach	NOUN
gs-4132	404	14	.	.	PUNCT
gs-4132	405	1	exosomes	exosome	NOUN
gs-4132	405	2	are	be	AUX
gs-4132	405	3	being	be	AUX
gs-4132	405	4	engineered	engineer	VERB
gs-4132	405	5	to	to	PART
gs-4132	405	6	carry	carry	VERB
gs-4132	405	7	therapeutic	therapeutic	ADJ
gs-4132	405	8	payloads	payload	NOUN
gs-4132	405	9	,	,	PUNCT
gs-4132	405	10	imaging	imaging	NOUN
gs-4132	405	11	agents	agent	NOUN
gs-4132	405	12	,	,	PUNCT
gs-4132	405	13	and	and	CCONJ
gs-4132	405	14	targeting	target	VERB
gs-4132	405	15	ligands	ligand	NOUN
gs-4132	405	16	simultaneously	simultaneously	ADV
gs-4132	405	17	,	,	PUNCT
gs-4132	405	18	enabling	enable	VERB
gs-4132	405	19	integrated	integrated	ADJ
gs-4132	405	20	diagnosis	diagnosis	NOUN
gs-4132	405	21	and	and	CCONJ
gs-4132	405	22	therapy	therapy	NOUN
gs-4132	405	23	.	.	PUNCT
gs-4132	406	1	synthetic	synthetic	ADJ
gs-4132	406	2	nanoparticles	nanoparticle	NOUN
gs-4132	406	3	continue	continue	VERB
gs-4132	406	4	to	to	PART
gs-4132	406	5	evolve	evolve	VERB
gs-4132	406	6	toward	toward	ADP
gs-4132	406	7	stimuli	stimulus	NOUN
gs-4132	406	8	-	-	PUNCT
gs-4132	406	9	responsive	responsive	ADJ
gs-4132	406	10	systems	system	NOUN
gs-4132	406	11	that	that	PRON
gs-4132	406	12	release	release	VERB
gs-4132	406	13	cargo	cargo	NOUN
gs-4132	406	14	in	in	ADP
gs-4132	406	15	response	response	NOUN
gs-4132	406	16	to	to	ADP
gs-4132	406	17	ph	ph	ADJ
gs-4132	406	18	,	,	PUNCT
gs-4132	406	19	temperature	temperature	NOUN
gs-4132	406	20	,	,	PUNCT
gs-4132	406	21	enzymatic	enzymatic	ADJ
gs-4132	406	22	activity	activity	NOUN
gs-4132	406	23	,	,	PUNCT
gs-4132	406	24	or	or	CCONJ
gs-4132	406	25	external	external	ADJ
gs-4132	406	26	triggers	trigger	NOUN
gs-4132	406	27	such	such	ADJ
gs-4132	406	28	as	as	ADP
gs-4132	406	29	light	light	NOUN
gs-4132	406	30	or	or	CCONJ
gs-4132	406	31	magnetic	magnetic	ADJ
gs-4132	406	32	fields	field	NOUN
gs-4132	406	33	.	.	PUNCT
gs-4132	407	1	the	the	DET
gs-4132	407	2	combination	combination	NOUN
gs-4132	407	3	of	of	ADP
gs-4132	407	4	biological	biological	ADJ
gs-4132	407	5	and	and	CCONJ
gs-4132	407	6	synthetic	synthetic	ADJ
gs-4132	407	7	elements	element	NOUN
gs-4132	407	8	in	in	ADP
gs-4132	407	9	hybrid	hybrid	ADJ
gs-4132	407	10	nanocarriers	nanocarrier	NOUN
gs-4132	407	11	represents	represent	VERB
gs-4132	407	12	a	a	DET
gs-4132	407	13	strategic	strategic	ADJ
gs-4132	407	14	approach	approach	NOUN
gs-4132	407	15	to	to	PART
gs-4132	407	16	maximize	maximize	VERB
gs-4132	407	17	therapeutic	therapeutic	ADJ
gs-4132	407	18	efficacy	efficacy	NOUN
gs-4132	407	19	,	,	PUNCT
gs-4132	407	20	minimize	minimize	VERB
gs-4132	407	21	toxicity	toxicity	NOUN
gs-4132	407	22	,	,	PUNCT
gs-4132	407	23	and	and	CCONJ
gs-4132	407	24	achieve	achieve	VERB
gs-4132	407	25	precise	precise	ADJ
gs-4132	407	26	spatiotemporal	spatiotemporal	ADJ
gs-4132	407	27	control	control	NOUN
gs-4132	407	28	over	over	ADP
gs-4132	407	29	delivery	delivery	NOUN
gs-4132	407	30	.	.	PUNCT
gs-4132	408	1	regulatory	regulatory	ADJ
gs-4132	408	2	harmonization	harmonization	NOUN
gs-4132	408	3	,	,	PUNCT
gs-4132	408	4	scalable	scalable	ADJ
gs-4132	408	5	manufacturing	manufacturing	NOUN
gs-4132	408	6	,	,	PUNCT
gs-4132	408	7	and	and	CCONJ
gs-4132	408	8	quality	quality	NOUN
gs-4132	408	9	assurance	assurance	NOUN
gs-4132	408	10	remain	remain	VERB
gs-4132	408	11	critical	critical	ADJ
gs-4132	408	12	challenges	challenge	NOUN
gs-4132	408	13	,	,	PUNCT
gs-4132	408	14	requiring	require	VERB
gs-4132	408	15	collaboration	collaboration	NOUN
gs-4132	408	16	across	across	ADP
gs-4132	408	17	academic	academic	ADJ
gs-4132	408	18	,	,	PUNCT
gs-4132	408	19	industrial	industrial	ADJ
gs-4132	408	20	,	,	PUNCT
gs-4132	408	21	and	and	CCONJ
gs-4132	408	22	regulatory	regulatory	ADJ
gs-4132	408	23	sectors	sector	NOUN
gs-4132	408	24	to	to	PART
gs-4132	408	25	ensure	ensure	VERB
gs-4132	408	26	safe	safe	ADJ
gs-4132	408	27	and	and	CCONJ
gs-4132	408	28	effective	effective	ADJ
gs-4132	408	29	clinical	clinical	ADJ
gs-4132	408	30	translation	translation	NOUN
gs-4132	408	31	.	.	PUNCT
gs-4132	409	1	georgian	georgian	PROPN
gs-4132	409	2	scientists/	scientists/	NUM
gs-4132	409	3	.	.	PUNCT
gs-4132	410	1	7	7	NUM
gs-4132	410	2	n	n	DET
gs-4132	410	3	4	4	NUM
gs-4132	410	4	,	,	PUNCT
gs-4132	410	5	2025	2025	NUM
gs-4132	410	6	25	25	NUM
gs-4132	410	7	the	the	DET
gs-4132	410	8	exosomes	exosome	NOUN
gs-4132	410	9	and	and	CCONJ
gs-4132	410	10	synthetic	synthetic	ADJ
gs-4132	410	11	nanocarriers	nanocarrier	NOUN
gs-4132	410	12	each	each	PRON
gs-4132	410	13	offer	offer	VERB
gs-4132	410	14	unique	unique	ADJ
gs-4132	410	15	advantages	advantage	NOUN
gs-4132	410	16	and	and	CCONJ
gs-4132	410	17	face	face	VERB
gs-4132	410	18	distinct	distinct	ADJ
gs-4132	410	19	limitations	limitation	NOUN
gs-4132	410	20	,	,	PUNCT
gs-4132	410	21	underscoring	underscore	VERB
gs-4132	410	22	the	the	DET
gs-4132	410	23	complementary	complementary	ADJ
gs-4132	410	24	nature	nature	NOUN
gs-4132	410	25	of	of	ADP
gs-4132	410	26	these	these	DET
gs-4132	410	27	platforms	platform	NOUN
gs-4132	410	28	.	.	PUNCT
gs-4132	411	1	exosomes	exosome	NOUN
gs-4132	411	2	provide	provide	VERB
gs-4132	411	3	inherent	inherent	ADJ
gs-4132	411	4	targeting	targeting	NOUN
gs-4132	411	5	,	,	PUNCT
gs-4132	411	6	biocompatibility	biocompatibility	NOUN
gs-4132	411	7	,	,	PUNCT
gs-4132	411	8	and	and	CCONJ
gs-4132	411	9	bioactivity	bioactivity	NOUN
gs-4132	411	10	,	,	PUNCT
gs-4132	411	11	while	while	SCONJ
gs-4132	411	12	synthetic	synthetic	ADJ
gs-4132	411	13	nanocarriers	nanocarrier	NOUN
gs-4132	411	14	offer	offer	VERB
gs-4132	411	15	tunable	tunable	ADJ
gs-4132	411	16	physicochemical	physicochemical	ADJ
gs-4132	411	17	properties	property	NOUN
gs-4132	411	18	,	,	PUNCT
gs-4132	411	19	multifunctionality	multifunctionality	NOUN
gs-4132	411	20	,	,	PUNCT
gs-4132	411	21	and	and	CCONJ
gs-4132	411	22	reproducibility	reproducibility	NOUN
gs-4132	411	23	.	.	PUNCT
gs-4132	412	1	the	the	DET
gs-4132	412	2	development	development	NOUN
gs-4132	412	3	of	of	ADP
gs-4132	412	4	hybrid	hybrid	NOUN
gs-4132	412	5	systems	system	NOUN
gs-4132	412	6	,	,	PUNCT
gs-4132	412	7	advanced	advanced	ADJ
gs-4132	412	8	engineering	engineering	NOUN
gs-4132	412	9	techniques	technique	NOUN
gs-4132	412	10	,	,	PUNCT
gs-4132	412	11	and	and	CCONJ
gs-4132	412	12	personalized	personalized	ADJ
gs-4132	412	13	nanomedicine	nanomedicine	ADJ
gs-4132	412	14	approaches	approach	NOUN
gs-4132	412	15	holds	hold	VERB
gs-4132	412	16	significant	significant	ADJ
gs-4132	412	17	promise	promise	NOUN
gs-4132	412	18	for	for	ADP
gs-4132	412	19	overcoming	overcome	VERB
gs-4132	412	20	existing	exist	VERB
gs-4132	412	21	challenges	challenge	NOUN
gs-4132	412	22	and	and	CCONJ
gs-4132	412	23	expanding	expand	VERB
gs-4132	412	24	the	the	DET
gs-4132	412	25	therapeutic	therapeutic	ADJ
gs-4132	412	26	potential	potential	NOUN
gs-4132	412	27	of	of	ADP
gs-4132	412	28	these	these	DET
gs-4132	412	29	platforms	platform	NOUN
gs-4132	412	30	.	.	PUNCT
gs-4132	413	1	continued	continue	VERB
gs-4132	413	2	research	research	NOUN
gs-4132	413	3	into	into	ADP
gs-4132	413	4	mechanistic	mechanistic	ADJ
gs-4132	413	5	insights	insight	NOUN
gs-4132	413	6	,	,	PUNCT
gs-4132	413	7	scalable	scalable	ADJ
gs-4132	413	8	production	production	NOUN
gs-4132	413	9	methods	method	NOUN
gs-4132	413	10	,	,	PUNCT
gs-4132	413	11	safety	safety	NOUN
gs-4132	413	12	assessment	assessment	NOUN
gs-4132	413	13	,	,	PUNCT
gs-4132	413	14	and	and	CCONJ
gs-4132	413	15	clinical	clinical	ADJ
gs-4132	413	16	translation	translation	NOUN
gs-4132	413	17	is	be	AUX
gs-4132	413	18	essential	essential	ADJ
gs-4132	413	19	to	to	PART
gs-4132	413	20	fully	fully	ADV
gs-4132	413	21	realize	realize	VERB
gs-4132	413	22	the	the	DET
gs-4132	413	23	transformative	transformative	ADJ
gs-4132	413	24	potential	potential	NOUN
gs-4132	413	25	of	of	ADP
gs-4132	413	26	exosomeand	exosomeand	NOUN
gs-4132	413	27	nanoparticle	nanoparticle	NOUN
gs-4132	413	28	-	-	PUNCT
gs-4132	413	29	based	base	VERB
gs-4132	413	30	therapeutics	therapeutic	NOUN
gs-4132	413	31	.	.	PUNCT
gs-4132	414	1	by	by	ADP
gs-4132	414	2	integrating	integrate	VERB
gs-4132	414	3	biological	biological	ADJ
gs-4132	414	4	principles	principle	NOUN
gs-4132	414	5	with	with	ADP
gs-4132	414	6	engineering	engineering	NOUN
gs-4132	414	7	innovation	innovation	NOUN
gs-4132	414	8	,	,	PUNCT
gs-4132	414	9	the	the	DET
gs-4132	414	10	next	next	ADJ
gs-4132	414	11	generation	generation	NOUN
gs-4132	414	12	of	of	ADP
gs-4132	414	13	nanomedicine	nanomedicine	NOUN
gs-4132	414	14	is	be	AUX
gs-4132	414	15	poised	poise	VERB
gs-4132	414	16	to	to	PART
gs-4132	414	17	revolutionize	revolutionize	VERB
gs-4132	414	18	disease	disease	NOUN
gs-4132	414	19	treatment	treatment	NOUN
gs-4132	414	20	,	,	PUNCT
gs-4132	414	21	improve	improve	VERB
gs-4132	414	22	patient	patient	ADJ
gs-4132	414	23	outcomes	outcome	NOUN
gs-4132	414	24	,	,	PUNCT
gs-4132	414	25	and	and	CCONJ
gs-4132	414	26	establish	establish	VERB
gs-4132	414	27	a	a	DET
gs-4132	414	28	new	new	ADJ
gs-4132	414	29	standard	standard	NOUN
gs-4132	414	30	for	for	ADP
gs-4132	414	31	precision	precision	NOUN
gs-4132	414	32	,	,	PUNCT
gs-4132	414	33	safe	safe	ADJ
gs-4132	414	34	,	,	PUNCT
gs-4132	414	35	and	and	CCONJ
gs-4132	414	36	effective	effective	ADJ
gs-4132	414	37	therapeutic	therapeutic	ADJ
gs-4132	414	38	delivery	delivery	NOUN
gs-4132	414	39	.	.	PUNCT
gs-4132	415	1	10	10	NUM
gs-4132	415	2	.	.	PUNCT
gs-4132	415	3	conclusion	conclusion	NOUN
gs-4132	415	4	exosomes	exosome	NOUN
gs-4132	415	5	and	and	CCONJ
gs-4132	415	6	synthetic	synthetic	ADJ
gs-4132	415	7	nanoparticles	nanoparticle	NOUN
gs-4132	415	8	such	such	ADJ
gs-4132	415	9	as	as	ADP
gs-4132	415	10	liposomes	liposome	NOUN
gs-4132	415	11	represent	represent	VERB
gs-4132	415	12	two	two	NUM
gs-4132	415	13	complementary	complementary	ADJ
gs-4132	415	14	paradigms	paradigm	NOUN
gs-4132	415	15	in	in	ADP
gs-4132	415	16	therapeutic	therapeutic	ADJ
gs-4132	415	17	delivery	delivery	NOUN
gs-4132	415	18	.	.	PUNCT
gs-4132	416	1	exosomes	exosome	NOUN
gs-4132	416	2	,	,	PUNCT
gs-4132	416	3	with	with	ADP
gs-4132	416	4	their	their	PRON
gs-4132	416	5	natural	natural	ADJ
gs-4132	416	6	origin	origin	NOUN
gs-4132	416	7	,	,	PUNCT
gs-4132	416	8	biocompatibility	biocompatibility	NOUN
gs-4132	416	9	,	,	PUNCT
gs-4132	416	10	and	and	CCONJ
gs-4132	416	11	targeting	target	VERB
gs-4132	416	12	capabilities	capability	NOUN
gs-4132	416	13	,	,	PUNCT
gs-4132	416	14	are	be	AUX
gs-4132	416	15	poised	poise	VERB
gs-4132	416	16	to	to	PART
gs-4132	416	17	revolutionize	revolutionize	VERB
gs-4132	416	18	personalized	personalized	ADJ
gs-4132	416	19	medicine	medicine	NOUN
gs-4132	416	20	but	but	CCONJ
gs-4132	416	21	face	face	VERB
gs-4132	416	22	hurdles	hurdle	NOUN
gs-4132	416	23	in	in	ADP
gs-4132	416	24	scalability	scalability	NOUN
gs-4132	416	25	and	and	CCONJ
gs-4132	416	26	standardization	standardization	NOUN
gs-4132	416	27	.	.	PUNCT
gs-4132	417	1	liposomes	liposome	NOUN
gs-4132	417	2	,	,	PUNCT
gs-4132	417	3	by	by	ADP
gs-4132	417	4	contrast	contrast	NOUN
gs-4132	417	5	,	,	PUNCT
gs-4132	417	6	have	have	VERB
gs-4132	417	7	decades	decade	NOUN
gs-4132	417	8	of	of	ADP
gs-4132	417	9	clinical	clinical	ADJ
gs-4132	417	10	validation	validation	NOUN
gs-4132	417	11	,	,	PUNCT
gs-4132	417	12	offering	offer	VERB
gs-4132	417	13	predictable	predictable	ADJ
gs-4132	417	14	and	and	CCONJ
gs-4132	417	15	reproducible	reproducible	ADJ
gs-4132	417	16	platforms	platform	NOUN
gs-4132	417	17	,	,	PUNCT
gs-4132	417	18	yet	yet	CCONJ
gs-4132	417	19	lack	lack	VERB
gs-4132	417	20	the	the	DET
gs-4132	417	21	biological	biological	ADJ
gs-4132	417	22	sophistication	sophistication	NOUN
gs-4132	417	23	of	of	ADP
gs-4132	417	24	exosomes	exosome	NOUN
gs-4132	417	25	.	.	PUNCT
gs-4132	418	1	the	the	DET
gs-4132	418	2	future	future	NOUN
gs-4132	418	3	likely	likely	ADV
gs-4132	418	4	lies	lie	VERB
gs-4132	418	5	in	in	ADP
gs-4132	418	6	hybrid	hybrid	ADJ
gs-4132	418	7	strategies	strategy	NOUN
gs-4132	418	8	:	:	PUNCT
gs-4132	418	9	exosome	exosome	NOUN
gs-4132	418	10	-	-	PUNCT
gs-4132	418	11	inspired	inspire	VERB
gs-4132	418	12	synthetic	synthetic	ADJ
gs-4132	418	13	vesicles	vesicle	NOUN
gs-4132	418	14	,	,	PUNCT
gs-4132	418	15	exosome	exosome	NOUN
gs-4132	418	16	-	-	PUNCT
gs-4132	418	17	liposome	liposome	NOUN
gs-4132	418	18	chimeras	chimera	NOUN
gs-4132	418	19	,	,	PUNCT
gs-4132	418	20	and	and	CCONJ
gs-4132	418	21	personalized	personalize	VERB
gs-4132	418	22	exosome	exosome	PROPN
gs-4132	418	23	therapies	therapy	NOUN
gs-4132	418	24	integrated	integrate	VERB
gs-4132	418	25	with	with	ADP
gs-4132	418	26	synthetic	synthetic	ADJ
gs-4132	418	27	nanocarriers	nanocarrier	NOUN
gs-4132	418	28	.	.	PUNCT
gs-4132	419	1	overcoming	overcome	VERB
gs-4132	419	2	manufacturing	manufacturing	NOUN
gs-4132	419	3	,	,	PUNCT
gs-4132	419	4	regulatory	regulatory	ADJ
gs-4132	419	5	,	,	PUNCT
gs-4132	419	6	and	and	CCONJ
gs-4132	419	7	safety	safety	NOUN
gs-4132	419	8	challenges	challenge	NOUN
gs-4132	419	9	will	will	AUX
gs-4132	419	10	be	be	AUX
gs-4132	419	11	essential	essential	ADJ
gs-4132	419	12	for	for	SCONJ
gs-4132	419	13	both	both	DET
gs-4132	419	14	systems	system	NOUN
gs-4132	419	15	to	to	PART
gs-4132	419	16	achieve	achieve	VERB
gs-4132	419	17	widespread	widespread	ADJ
gs-4132	419	18	clinical	clinical	ADJ
gs-4132	419	19	adoption	adoption	NOUN
gs-4132	419	20	.	.	PUNCT
gs-4132	420	1	references	reference	NOUN
gs-4132	420	2	adler	adler	PROPN
gs-4132	420	3	-	-	PUNCT
gs-4132	420	4	moore	moore	PROPN
gs-4132	420	5	,	,	PUNCT
gs-4132	420	6	j.	j.	PROPN
gs-4132	420	7	,	,	PUNCT
gs-4132	420	8	&	&	CCONJ
gs-4132	420	9	proffitt	proffitt	PROPN
gs-4132	420	10	,	,	PUNCT
gs-4132	420	11	r.	r.	PROPN
gs-4132	420	12	t.	t.	PROPN
gs-4132	420	13	(	(	PUNCT
gs-4132	420	14	2002	2002	NUM
gs-4132	420	15	)	)	PUNCT
gs-4132	420	16	.	.	PUNCT
gs-4132	421	1	amphotericin	amphotericin	ADP
gs-4132	421	2	b	b	PROPN
gs-4132	421	3	lipid	lipid	NOUN
gs-4132	421	4	preparations	preparation	NOUN
gs-4132	421	5	:	:	PUNCT
gs-4132	421	6	what	what	PRON
gs-4132	421	7	are	be	AUX
gs-4132	421	8	the	the	DET
gs-4132	421	9	differences	difference	NOUN
gs-4132	421	10	?	?	PUNCT
gs-4132	422	1	clinical	clinical	ADJ
gs-4132	422	2	microbiology	microbiology	NOUN
gs-4132	422	3	and	and	CCONJ
gs-4132	422	4	infection	infection	NOUN
gs-4132	422	5	,	,	PUNCT
gs-4132	422	6	8(suppl	8(suppl	PROPN
gs-4132	422	7	4	4	NUM
gs-4132	422	8	)	)	PUNCT
gs-4132	422	9	,	,	PUNCT
gs-4132	422	10	27–34	27–34	NUM
gs-4132	422	11	.	.	PUNCT
gs-4132	422	12	allen	allen	PROPN
gs-4132	422	13	,	,	PUNCT
gs-4132	422	14	t.	t.	NOUN
gs-4132	422	15	m.	m.	NOUN
gs-4132	422	16	,	,	PUNCT
gs-4132	422	17	&	&	CCONJ
gs-4132	422	18	cullis	cullis	PROPN
gs-4132	422	19	,	,	PUNCT
gs-4132	422	20	p.	p.	PROPN
gs-4132	422	21	r.	r.	PROPN
gs-4132	422	22	(	(	PUNCT
gs-4132	422	23	2013	2013	NUM
gs-4132	422	24	)	)	PUNCT
gs-4132	422	25	.	.	PUNCT
gs-4132	423	1	liposomal	liposomal	PROPN
gs-4132	423	2	drug	drug	PROPN
gs-4132	423	3	delivery	delivery	NOUN
gs-4132	423	4	systems	system	NOUN
gs-4132	423	5	:	:	PUNCT
gs-4132	423	6	from	from	ADP
gs-4132	423	7	concept	concept	NOUN
gs-4132	423	8	to	to	ADP
gs-4132	423	9	clinical	clinical	ADJ
gs-4132	423	10	applications	application	NOUN
gs-4132	423	11	.	.	PUNCT
gs-4132	424	1	advanced	advanced	ADJ
gs-4132	424	2	drug	drug	NOUN
gs-4132	424	3	delivery	delivery	NOUN
gs-4132	424	4	reviews	review	NOUN
gs-4132	424	5	,	,	PUNCT
gs-4132	424	6	65(1	65(1	NOUN
gs-4132	424	7	)	)	PUNCT
gs-4132	424	8	,	,	PUNCT
gs-4132	424	9	36–48	36–48	NUM
gs-4132	424	10	.	.	PUNCT
gs-4132	425	1	alvarez	alvarez	PROPN
gs-4132	425	2	-	-	PUNCT
gs-4132	425	3	erviti	erviti	PROPN
gs-4132	425	4	,	,	PUNCT
gs-4132	425	5	l.	l.	PROPN
gs-4132	425	6	,	,	PUNCT
gs-4132	425	7	seow	seow	PROPN
gs-4132	425	8	,	,	PUNCT
gs-4132	425	9	y.	y.	PROPN
gs-4132	425	10	,	,	PUNCT
gs-4132	425	11	yin	yin	PROPN
gs-4132	425	12	,	,	PUNCT
gs-4132	425	13	h.	h.	PROPN
gs-4132	425	14	,	,	PUNCT
gs-4132	425	15	betts	betts	PROPN
gs-4132	425	16	,	,	PUNCT
gs-4132	425	17	c.	c.	PROPN
gs-4132	425	18	,	,	PUNCT
gs-4132	425	19	lakhal	lakhal	NOUN
gs-4132	425	20	,	,	PUNCT
gs-4132	425	21	s.	s.	PROPN
gs-4132	425	22	,	,	PUNCT
gs-4132	425	23	&	&	CCONJ
gs-4132	425	24	wood	wood	PROPN
gs-4132	425	25	,	,	PUNCT
gs-4132	425	26	m.	m.	NOUN
gs-4132	425	27	j.	j.	PROPN
gs-4132	425	28	(	(	PUNCT
gs-4132	425	29	2011	2011	NUM
gs-4132	425	30	)	)	PUNCT
gs-4132	425	31	.	.	PUNCT
gs-4132	426	1	delivery	delivery	NOUN
gs-4132	426	2	of	of	ADP
gs-4132	426	3	sirna	sirna	PROPN
gs-4132	426	4	to	to	ADP
gs-4132	426	5	the	the	DET
gs-4132	426	6	mouse	mouse	NOUN
gs-4132	426	7	brain	brain	NOUN
gs-4132	426	8	by	by	ADP
gs-4132	426	9	systemic	systemic	ADJ
gs-4132	426	10	injection	injection	NOUN
gs-4132	426	11	of	of	ADP
gs-4132	426	12	targeted	target	VERB
gs-4132	426	13	exosomes	exosome	NOUN
gs-4132	426	14	.	.	PUNCT
gs-4132	427	1	nature	nature	NOUN
gs-4132	427	2	biotechnology	biotechnology	NOUN
gs-4132	427	3	,	,	PUNCT
gs-4132	427	4	29(4	29(4	NOUN
gs-4132	427	5	)	)	PUNCT
gs-4132	427	6	,	,	PUNCT
gs-4132	427	7	341–345	341–345	NUM
gs-4132	427	8	.	.	PUNCT
gs-4132	428	1	atkin	atkin	PROPN
gs-4132	428	2	-	-	PUNCT
gs-4132	428	3	smith	smith	PROPN
gs-4132	428	4	,	,	PUNCT
gs-4132	428	5	g.	g.	PROPN
gs-4132	428	6	k.	k.	PROPN
gs-4132	428	7	,	,	PUNCT
gs-4132	428	8	&	&	CCONJ
gs-4132	428	9	poon	poon	NOUN
gs-4132	428	10	,	,	PUNCT
gs-4132	428	11	i.	i.	PROPN
gs-4132	428	12	k.	k.	PROPN
gs-4132	428	13	(	(	PUNCT
gs-4132	428	14	2017	2017	NUM
gs-4132	428	15	)	)	PUNCT
gs-4132	428	16	.	.	PUNCT
gs-4132	429	1	disassembly	disassembly	ADV
gs-4132	429	2	of	of	ADP
gs-4132	429	3	the	the	DET
gs-4132	429	4	dying	dying	NOUN
gs-4132	429	5	:	:	PUNCT
gs-4132	429	6	mechanisms	mechanism	NOUN
gs-4132	429	7	and	and	CCONJ
gs-4132	429	8	functions	function	NOUN
gs-4132	429	9	.	.	PUNCT
gs-4132	430	1	trends	trend	NOUN
gs-4132	430	2	in	in	ADP
gs-4132	430	3	cell	cell	NOUN
gs-4132	430	4	biology	biology	NOUN
gs-4132	430	5	,	,	PUNCT
gs-4132	430	6	27(2	27(2	NUM
gs-4132	430	7	)	)	PUNCT
gs-4132	430	8	,	,	PUNCT
gs-4132	430	9	151–162	151–162	NUM
gs-4132	430	10	.	.	PUNCT
gs-4132	431	1	bangham	bangham	PROPN
gs-4132	431	2	,	,	PUNCT
gs-4132	431	3	a.	a.	PROPN
gs-4132	431	4	d.	d.	PROPN
gs-4132	431	5	,	,	PUNCT
gs-4132	431	6	standish	standish	PROPN
gs-4132	431	7	,	,	PUNCT
gs-4132	431	8	m.	m.	NOUN
gs-4132	431	9	m.	m.	NOUN
gs-4132	431	10	,	,	PUNCT
gs-4132	431	11	&	&	CCONJ
gs-4132	431	12	watkins	watkins	PROPN
gs-4132	431	13	,	,	PUNCT
gs-4132	431	14	j.	j.	PROPN
gs-4132	431	15	c.	c.	PROPN
gs-4132	431	16	(	(	PUNCT
gs-4132	431	17	1965	1965	NUM
gs-4132	431	18	)	)	PUNCT
gs-4132	431	19	.	.	PUNCT
gs-4132	432	1	diffusion	diffusion	NOUN
gs-4132	432	2	of	of	ADP
gs-4132	432	3	univalent	univalent	ADJ
gs-4132	432	4	ions	ion	NOUN
gs-4132	432	5	across	across	ADP
gs-4132	432	6	the	the	DET
gs-4132	432	7	lamellae	lamellae	NOUN
gs-4132	432	8	of	of	ADP
gs-4132	432	9	swollen	swollen	ADJ
gs-4132	432	10	phospholipids	phospholipid	NOUN
gs-4132	432	11	.	.	PUNCT
gs-4132	433	1	journal	journal	NOUN
gs-4132	433	2	of	of	ADP
gs-4132	433	3	molecular	molecular	ADJ
gs-4132	433	4	biology	biology	NOUN
gs-4132	433	5	,	,	PUNCT
gs-4132	433	6	13(1	13(1	NUM
gs-4132	433	7	)	)	PUNCT
gs-4132	433	8	,	,	PUNCT
gs-4132	433	9	238	238	NUM
gs-4132	433	10	–	–	PUNCT
gs-4132	433	11	252	252	NUM
gs-4132	433	12	.	.	PUNCT
gs-4132	434	1	barenholz	barenholz	NOUN
gs-4132	434	2	,	,	PUNCT
gs-4132	434	3	y.	y.	PROPN
gs-4132	434	4	(	(	PUNCT
gs-4132	434	5	2012	2012	NUM
gs-4132	434	6	)	)	PUNCT
gs-4132	434	7	.	.	PUNCT
gs-4132	435	1	doxil	doxil	PROPN
gs-4132	435	2	®	®	PROPN
gs-4132	435	3	—the	—the	DET
gs-4132	435	4	first	first	ADJ
gs-4132	435	5	fda	fda	PROPN
gs-4132	435	6	-	-	PUNCT
gs-4132	435	7	approved	approve	VERB
gs-4132	435	8	nano	nano	NOUN
gs-4132	435	9	-	-	PUNCT
gs-4132	435	10	drug	drug	NOUN
gs-4132	435	11	:	:	PUNCT
gs-4132	435	12	lessons	lesson	NOUN
gs-4132	435	13	learned	learn	VERB
gs-4132	435	14	.	.	PUNCT
gs-4132	436	1	journal	journal	PROPN
gs-4132	436	2	of	of	ADP
gs-4132	436	3	controlled	control	VERB
gs-4132	436	4	release	release	NOUN
gs-4132	436	5	,	,	PUNCT
gs-4132	436	6	160(2	160(2	NUM
gs-4132	436	7	)	)	PUNCT
gs-4132	436	8	,	,	PUNCT
gs-4132	436	9	117–134	117–134	NUM
gs-4132	436	10	.	.	PUNCT
gs-4132	437	1	georgian	georgian	NOUN
gs-4132	437	2	scientists/	scientists/	NUM
gs-4132	437	3	.	.	PUNCT
gs-4132	438	1	7	7	NUM
gs-4132	438	2	n	n	DET
gs-4132	438	3	4	4	NUM
gs-4132	438	4	,	,	PUNCT
gs-4132	438	5	2025	2025	NUM
gs-4132	438	6	26	26	NUM
gs-4132	438	7	böing	böing	NOUN
gs-4132	438	8	,	,	PUNCT
gs-4132	438	9	a.	a.	NOUN
gs-4132	438	10	n.	n.	PROPN
gs-4132	438	11	,	,	PUNCT
gs-4132	438	12	van	van	PROPN
gs-4132	438	13	der	der	PROPN
gs-4132	438	14	pol	pol	PROPN
gs-4132	438	15	,	,	PUNCT
gs-4132	438	16	e.	e.	PROPN
gs-4132	438	17	,	,	PUNCT
gs-4132	438	18	grootemaat	grootemaat	PROPN
gs-4132	438	19	,	,	PUNCT
gs-4132	438	20	a.	a.	PROPN
gs-4132	438	21	e.	e.	PROPN
gs-4132	438	22	,	,	PUNCT
gs-4132	438	23	coumans	coumans	PROPN
gs-4132	438	24	,	,	PUNCT
gs-4132	438	25	f.	f.	PROPN
gs-4132	438	26	a.	a.	PROPN
gs-4132	438	27	,	,	PUNCT
gs-4132	438	28	sturk	sturk	PROPN
gs-4132	438	29	,	,	PUNCT
gs-4132	438	30	a.	a.	NOUN
gs-4132	438	31	,	,	PUNCT
gs-4132	438	32	&	&	CCONJ
gs-4132	438	33	nieuwland	nieuwland	PROPN
gs-4132	438	34	,	,	PUNCT
gs-4132	438	35	r.	r.	PROPN
gs-4132	438	36	(	(	PUNCT
gs-4132	438	37	2014	2014	NUM
gs-4132	438	38	)	)	PUNCT
gs-4132	438	39	.	.	PUNCT
gs-4132	439	1	single	single	ADJ
gs-4132	439	2	-	-	PUNCT
gs-4132	439	3	step	step	NOUN
gs-4132	439	4	isolation	isolation	NOUN
gs-4132	439	5	of	of	ADP
gs-4132	439	6	extracellular	extracellular	ADJ
gs-4132	439	7	vesicles	vesicle	NOUN
gs-4132	439	8	by	by	ADP
gs-4132	439	9	size	size	NOUN
gs-4132	439	10	-	-	PUNCT
gs-4132	439	11	exclusion	exclusion	NOUN
gs-4132	439	12	chromatography	chromatography	NOUN
gs-4132	439	13	.	.	PUNCT
gs-4132	440	1	journal	journal	NOUN
gs-4132	440	2	of	of	ADP
gs-4132	440	3	extracellular	extracellular	ADJ
gs-4132	440	4	vesicles	vesicle	NOUN
gs-4132	440	5	,	,	PUNCT
gs-4132	440	6	3(1	3(1	NUM
gs-4132	440	7	)	)	PUNCT
gs-4132	440	8	,	,	PUNCT
gs-4132	440	9	23430	23430	NUM
gs-4132	440	10	.	.	PUNCT
gs-4132	441	1	busatto	busatto	PROPN
gs-4132	441	2	,	,	PUNCT
gs-4132	441	3	s.	s.	PROPN
gs-4132	441	4	,	,	PUNCT
gs-4132	441	5	vilanilam	vilanilam	PROPN
gs-4132	441	6	,	,	PUNCT
gs-4132	441	7	g.	g.	PROPN
gs-4132	441	8	,	,	PUNCT
gs-4132	441	9	ticer	ticer	NOUN
gs-4132	441	10	,	,	PUNCT
gs-4132	441	11	t.	t.	PROPN
gs-4132	441	12	,	,	PUNCT
gs-4132	441	13	lin	lin	PROPN
gs-4132	441	14	,	,	PUNCT
gs-4132	441	15	w.	w.	PROPN
gs-4132	441	16	l.	l.	PROPN
gs-4132	441	17	,	,	PUNCT
gs-4132	441	18	dickson	dickson	PROPN
gs-4132	441	19	,	,	PUNCT
gs-4132	441	20	d.	d.	PROPN
gs-4132	441	21	w.	w.	PROPN
gs-4132	441	22	,	,	PUNCT
gs-4132	441	23	shapiro	shapiro	PROPN
gs-4132	441	24	,	,	PUNCT
gs-4132	441	25	s.	s.	PROPN
gs-4132	441	26	,	,	PUNCT
gs-4132	441	27	...	...	PUNCT
gs-4132	441	28	&	&	CCONJ
gs-4132	441	29	tang	tang	PROPN
gs-4132	441	30	,	,	PUNCT
gs-4132	441	31	q.	q.	PROPN
gs-4132	441	32	(	(	PUNCT
gs-4132	441	33	2018	2018	NUM
gs-4132	441	34	)	)	PUNCT
gs-4132	441	35	.	.	PUNCT
gs-4132	442	1	tangential	tangential	ADJ
gs-4132	442	2	flow	flow	NOUN
gs-4132	442	3	filtration	filtration	NOUN
gs-4132	442	4	for	for	ADP
gs-4132	442	5	highly	highly	ADV
gs-4132	442	6	efficient	efficient	ADJ
gs-4132	442	7	concentration	concentration	NOUN
gs-4132	442	8	of	of	ADP
gs-4132	442	9	extracellular	extracellular	ADJ
gs-4132	442	10	vesicles	vesicle	NOUN
gs-4132	442	11	.	.	PUNCT
gs-4132	443	1	biochemical	biochemical	ADJ
gs-4132	443	2	and	and	CCONJ
gs-4132	443	3	biophysical	biophysical	ADJ
gs-4132	443	4	research	research	NOUN
gs-4132	443	5	communications	communication	NOUN
gs-4132	443	6	,	,	PUNCT
gs-4132	443	7	493(1	493(1	NUM
gs-4132	443	8	)	)	PUNCT
gs-4132	443	9	,	,	PUNCT
gs-4132	443	10	25–31	25–31	NUM
gs-4132	443	11	.	.	PUNCT
gs-4132	444	1	chen	chen	PROPN
gs-4132	444	2	,	,	PUNCT
gs-4132	444	3	g.	g.	PROPN
gs-4132	444	4	,	,	PUNCT
gs-4132	444	5	huang	huang	PROPN
gs-4132	444	6	,	,	PUNCT
gs-4132	444	7	a.	a.	PROPN
gs-4132	444	8	c.	c.	PROPN
gs-4132	444	9	,	,	PUNCT
gs-4132	444	10	zhang	zhang	PROPN
gs-4132	444	11	,	,	PUNCT
gs-4132	444	12	w.	w.	PROPN
gs-4132	444	13	,	,	PUNCT
gs-4132	444	14	zhang	zhang	PROPN
gs-4132	444	15	,	,	PUNCT
gs-4132	444	16	g.	g.	PROPN
gs-4132	444	17	,	,	PUNCT
gs-4132	444	18	wu	wu	PROPN
gs-4132	444	19	,	,	PUNCT
gs-4132	444	20	m.	m.	NOUN
gs-4132	444	21	,	,	PUNCT
gs-4132	444	22	xu	xu	PROPN
gs-4132	444	23	,	,	PUNCT
gs-4132	444	24	w.	w.	PROPN
gs-4132	444	25	,	,	PUNCT
gs-4132	444	26	...	...	PUNCT
gs-4132	444	27	&	&	CCONJ
gs-4132	444	28	guo	guo	PROPN
gs-4132	444	29	,	,	PUNCT
gs-4132	444	30	w.	w.	PROPN
gs-4132	444	31	(	(	PUNCT
gs-4132	444	32	2018	2018	NUM
gs-4132	444	33	)	)	PUNCT
gs-4132	444	34	.	.	PUNCT
gs-4132	445	1	exosomal	exosomal	ADJ
gs-4132	445	2	pd	pd	PROPN
gs-4132	445	3	-	-	PROPN
gs-4132	445	4	l1	l1	PROPN
gs-4132	445	5	contributes	contribute	VERB
gs-4132	445	6	to	to	ADP
gs-4132	445	7	immunosuppression	immunosuppression	NOUN
gs-4132	445	8	and	and	CCONJ
gs-4132	445	9	is	be	AUX
gs-4132	445	10	associated	associate	VERB
gs-4132	445	11	with	with	ADP
gs-4132	445	12	anti	anti	ADJ
gs-4132	445	13	-	-	ADJ
gs-4132	445	14	pd-1	pd-1	ADJ
gs-4132	445	15	response	response	NOUN
gs-4132	445	16	.	.	PUNCT
gs-4132	446	1	nature	nature	NOUN
gs-4132	446	2	,	,	PUNCT
gs-4132	446	3	560(7718	560(7718	PROPN
gs-4132	446	4	)	)	PUNCT
gs-4132	446	5	,	,	PUNCT
gs-4132	446	6	382–386	382–386	NUM
gs-4132	446	7	.	.	PUNCT
gs-4132	447	1	cocucci	cocucci	NOUN
gs-4132	447	2	,	,	PUNCT
gs-4132	447	3	e.	e.	PROPN
gs-4132	447	4	,	,	PUNCT
gs-4132	447	5	&	&	CCONJ
gs-4132	447	6	meldolesi	meldolesi	PROPN
gs-4132	447	7	,	,	PUNCT
gs-4132	447	8	j.	j.	PROPN
gs-4132	447	9	(	(	PUNCT
gs-4132	447	10	2015	2015	NUM
gs-4132	447	11	)	)	PUNCT
gs-4132	447	12	.	.	PUNCT
gs-4132	448	1	ectosomes	ectosome	NOUN
gs-4132	448	2	and	and	CCONJ
gs-4132	448	3	exosomes	exosome	NOUN
gs-4132	448	4	:	:	PUNCT
gs-4132	448	5	shedding	shed	VERB
gs-4132	448	6	the	the	DET
gs-4132	448	7	confusion	confusion	NOUN
gs-4132	448	8	between	between	ADP
gs-4132	448	9	extracellular	extracellular	ADJ
gs-4132	448	10	vesicles	vesicle	NOUN
gs-4132	448	11	.	.	PUNCT
gs-4132	449	1	trends	trend	NOUN
gs-4132	449	2	in	in	ADP
gs-4132	449	3	cell	cell	NOUN
gs-4132	449	4	biology	biology	NOUN
gs-4132	449	5	,	,	PUNCT
gs-4132	449	6	25(6	25(6	NUM
gs-4132	449	7	)	)	PUNCT
gs-4132	449	8	,	,	PUNCT
gs-4132	449	9	364–372	364–372	NUM
gs-4132	449	10	.	.	PUNCT
gs-4132	450	1	colombo	colombo	NOUN
gs-4132	450	2	,	,	PUNCT
gs-4132	450	3	m.	m.	NOUN
gs-4132	450	4	,	,	PUNCT
gs-4132	450	5	raposo	raposo	NOUN
gs-4132	450	6	,	,	PUNCT
gs-4132	450	7	g.	g.	PROPN
gs-4132	450	8	,	,	PUNCT
gs-4132	450	9	&	&	CCONJ
gs-4132	450	10	théry	théry	PROPN
gs-4132	450	11	,	,	PUNCT
gs-4132	450	12	c.	c.	PROPN
gs-4132	450	13	(	(	PUNCT
gs-4132	450	14	2014	2014	NUM
gs-4132	450	15	)	)	PUNCT
gs-4132	450	16	.	.	PUNCT
gs-4132	451	1	biogenesis	biogenesis	NOUN
gs-4132	451	2	,	,	PUNCT
gs-4132	451	3	secretion	secretion	NOUN
gs-4132	451	4	,	,	PUNCT
gs-4132	451	5	and	and	CCONJ
gs-4132	451	6	intercellular	intercellular	ADJ
gs-4132	451	7	interactions	interaction	NOUN
gs-4132	451	8	of	of	ADP
gs-4132	451	9	exosomes	exosome	NOUN
gs-4132	451	10	and	and	CCONJ
gs-4132	451	11	other	other	ADJ
gs-4132	451	12	extracellular	extracellular	ADJ
gs-4132	451	13	vesicles	vesicle	NOUN
gs-4132	451	14	.	.	PUNCT
gs-4132	452	1	annual	annual	ADJ
gs-4132	452	2	review	review	NOUN
gs-4132	452	3	of	of	ADP
gs-4132	452	4	cell	cell	NOUN
gs-4132	452	5	and	and	CCONJ
gs-4132	452	6	developmental	developmental	ADJ
gs-4132	452	7	biology	biology	NOUN
gs-4132	452	8	,	,	PUNCT
gs-4132	452	9	30	30	NUM
gs-4132	452	10	,	,	PUNCT
gs-4132	452	11	255–289	255–289	NUM
gs-4132	452	12	.	.	PUNCT
gs-4132	453	1	costa	costa	PROPN
gs-4132	453	2	,	,	PUNCT
gs-4132	453	3	p.	p.	NOUN
gs-4132	453	4	m.	m.	NOUN
gs-4132	453	5	,	,	PUNCT
gs-4132	453	6	cardoso	cardoso	PROPN
gs-4132	453	7	,	,	PUNCT
gs-4132	453	8	a.	a.	NOUN
gs-4132	453	9	l.	l.	PROPN
gs-4132	453	10	,	,	PUNCT
gs-4132	453	11	mendonça	mendonça	PROPN
gs-4132	453	12	,	,	PUNCT
gs-4132	453	13	l.	l.	PROPN
gs-4132	453	14	s.	s.	PROPN
gs-4132	453	15	,	,	PUNCT
gs-4132	453	16	serani	serani	PROPN
gs-4132	453	17	,	,	PUNCT
gs-4132	453	18	a.	a.	NOUN
gs-4132	453	19	,	,	PUNCT
gs-4132	453	20	custódio	custódio	PROPN
gs-4132	453	21	,	,	PUNCT
gs-4132	453	22	j.	j.	PROPN
gs-4132	453	23	b.	b.	PROPN
gs-4132	453	24	,	,	PUNCT
gs-4132	453	25	&	&	CCONJ
gs-4132	453	26	moreira	moreira	PROPN
gs-4132	453	27	,	,	PUNCT
gs-4132	453	28	j.	j.	PROPN
gs-4132	453	29	n.	n.	PROPN
gs-4132	453	30	(	(	PUNCT
gs-4132	453	31	2020	2020	NUM
gs-4132	453	32	)	)	PUNCT
gs-4132	453	33	.	.	PUNCT
gs-4132	454	1	the	the	DET
gs-4132	454	2	emerging	emerge	VERB
gs-4132	454	3	role	role	NOUN
gs-4132	454	4	of	of	ADP
gs-4132	454	5	artificial	artificial	ADJ
gs-4132	454	6	intelligence	intelligence	NOUN
gs-4132	454	7	in	in	ADP
gs-4132	454	8	nanomedicine	nanomedicine	PROPN
gs-4132	454	9	.	.	PUNCT
gs-4132	455	1	advanced	advanced	ADJ
gs-4132	455	2	drug	drug	NOUN
gs-4132	455	3	delivery	delivery	NOUN
gs-4132	455	4	reviews	review	NOUN
gs-4132	455	5	,	,	PUNCT
gs-4132	455	6	159	159	NUM
gs-4132	455	7	,	,	PUNCT
gs-4132	455	8	306–317	306–317	NUM
gs-4132	455	9	.	.	PUNCT
gs-4132	456	1	dai	dai	PROPN
gs-4132	456	2	,	,	PUNCT
gs-4132	456	3	s.	s.	PROPN
gs-4132	456	4	,	,	PUNCT
gs-4132	456	5	wei	wei	PROPN
gs-4132	456	6	,	,	PUNCT
gs-4132	456	7	d.	d.	PROPN
gs-4132	456	8	,	,	PUNCT
gs-4132	456	9	wu	wu	PROPN
gs-4132	456	10	,	,	PUNCT
gs-4132	456	11	z.	z.	PROPN
gs-4132	456	12	,	,	PUNCT
gs-4132	456	13	zhou	zhou	PROPN
gs-4132	456	14	,	,	PUNCT
gs-4132	456	15	x.	x.	PROPN
gs-4132	456	16	,	,	PUNCT
gs-4132	456	17	wei	wei	PROPN
gs-4132	456	18	,	,	PUNCT
gs-4132	456	19	x.	x.	PROPN
gs-4132	456	20	,	,	PUNCT
gs-4132	456	21	huang	huang	PROPN
gs-4132	456	22	,	,	PUNCT
gs-4132	456	23	h.	h.	PROPN
gs-4132	456	24	,	,	PUNCT
gs-4132	456	25	...	...	PUNCT
gs-4132	456	26	&	&	CCONJ
gs-4132	456	27	guo	guo	PROPN
gs-4132	456	28	,	,	PUNCT
gs-4132	456	29	z.	z.	PROPN
gs-4132	456	30	(	(	PUNCT
gs-4132	456	31	2008	2008	NUM
gs-4132	456	32	)	)	PUNCT
gs-4132	456	33	.	.	PUNCT
gs-4132	457	1	phase	phase	NOUN
gs-4132	457	2	i	i	PRON
gs-4132	457	3	clinical	clinical	ADJ
gs-4132	457	4	trial	trial	NOUN
gs-4132	457	5	of	of	ADP
gs-4132	457	6	autologous	autologous	ADJ
gs-4132	457	7	ascites	ascite	NOUN
gs-4132	457	8	-	-	PUNCT
gs-4132	457	9	derived	derive	VERB
gs-4132	457	10	exosomes	exosome	NOUN
gs-4132	457	11	combined	combine	VERB
gs-4132	457	12	with	with	ADP
gs-4132	457	13	gm	gm	PROPN
gs-4132	457	14	-	-	PUNCT
gs-4132	457	15	csf	csf	NOUN
gs-4132	457	16	for	for	ADP
gs-4132	457	17	colorectal	colorectal	ADJ
gs-4132	457	18	cancer	cancer	NOUN
gs-4132	457	19	.	.	PUNCT
gs-4132	458	1	molecular	molecular	ADJ
gs-4132	458	2	therapy	therapy	NOUN
gs-4132	458	3	,	,	PUNCT
gs-4132	458	4	16(4	16(4	NUM
gs-4132	458	5	)	)	PUNCT
gs-4132	458	6	,	,	PUNCT
gs-4132	458	7	782–790	782–790	NUM
gs-4132	458	8	.	.	PUNCT
gs-4132	459	1	danhier	danhier	PROPN
gs-4132	459	2	,	,	PUNCT
gs-4132	459	3	f.	f.	PROPN
gs-4132	459	4	(	(	PUNCT
gs-4132	459	5	2016	2016	NUM
gs-4132	459	6	)	)	PUNCT
gs-4132	459	7	.	.	PUNCT
gs-4132	460	1	to	to	PART
gs-4132	460	2	exploit	exploit	VERB
gs-4132	460	3	the	the	DET
gs-4132	460	4	tumor	tumor	NOUN
gs-4132	460	5	microenvironment	microenvironment	NOUN
gs-4132	460	6	:	:	PUNCT
gs-4132	460	7	since	since	SCONJ
gs-4132	460	8	the	the	DET
gs-4132	460	9	epr	epr	PROPN
gs-4132	460	10	effect	effect	NOUN
gs-4132	460	11	fails	fail	VERB
gs-4132	460	12	in	in	ADP
gs-4132	460	13	the	the	DET
gs-4132	460	14	clinic	clinic	NOUN
gs-4132	460	15	,	,	PUNCT
gs-4132	460	16	what	what	PRON
gs-4132	460	17	is	be	AUX
gs-4132	460	18	the	the	DET
gs-4132	460	19	future	future	NOUN
gs-4132	460	20	of	of	ADP
gs-4132	460	21	nanomedicine	nanomedicine	ADJ
gs-4132	460	22	?	?	PUNCT
gs-4132	461	1	journal	journal	PROPN
gs-4132	461	2	of	of	ADP
gs-4132	461	3	controlled	control	VERB
gs-4132	461	4	release	release	NOUN
gs-4132	461	5	,	,	PUNCT
gs-4132	461	6	244	244	NUM
gs-4132	461	7	,	,	PUNCT
gs-4132	461	8	108–121	108–121	NUM
gs-4132	461	9	.	.	PUNCT
gs-4132	462	1	danhier	danhier	PROPN
gs-4132	462	2	,	,	PUNCT
gs-4132	462	3	f.	f.	PROPN
gs-4132	462	4	,	,	PUNCT
gs-4132	462	5	ansorena	ansorena	PROPN
gs-4132	462	6	,	,	PUNCT
gs-4132	462	7	e.	e.	PROPN
gs-4132	462	8	,	,	PUNCT
gs-4132	462	9	silva	silva	PROPN
gs-4132	462	10	,	,	PUNCT
gs-4132	462	11	j.	j.	PROPN
gs-4132	462	12	m.	m.	PROPN
gs-4132	462	13	,	,	PUNCT
gs-4132	462	14	coco	coco	PROPN
gs-4132	462	15	,	,	PUNCT
gs-4132	462	16	r.	r.	PROPN
gs-4132	462	17	,	,	PUNCT
gs-4132	462	18	le	le	PROPN
gs-4132	462	19	breton	breton	PROPN
gs-4132	462	20	,	,	PUNCT
gs-4132	462	21	a.	a.	PROPN
gs-4132	462	22	,	,	PUNCT
gs-4132	462	23	&	&	CCONJ
gs-4132	462	24	préat	préat	PROPN
gs-4132	462	25	,	,	PUNCT
gs-4132	462	26	v.	v.	PROPN
gs-4132	462	27	(	(	PUNCT
gs-4132	462	28	2012	2012	NUM
gs-4132	462	29	)	)	PUNCT
gs-4132	462	30	.	.	PUNCT
gs-4132	463	1	plgabased	plgabase	VERB
gs-4132	463	2	nanoparticles	nanoparticle	NOUN
gs-4132	463	3	:	:	PUNCT
gs-4132	463	4	an	an	DET
gs-4132	463	5	overview	overview	NOUN
gs-4132	463	6	of	of	ADP
gs-4132	463	7	biomedical	biomedical	ADJ
gs-4132	463	8	applications	application	NOUN
gs-4132	463	9	.	.	PUNCT
gs-4132	464	1	journal	journal	PROPN
gs-4132	464	2	of	of	ADP
gs-4132	464	3	controlled	control	VERB
gs-4132	464	4	release	release	NOUN
gs-4132	464	5	,	,	PUNCT
gs-4132	464	6	161(2	161(2	NUM
gs-4132	464	7	)	)	PUNCT
gs-4132	464	8	,	,	PUNCT
gs-4132	464	9	505–522	505–522	NUM
gs-4132	464	10	.	.	PUNCT
gs-4132	465	1	emmanouilidou	emmanouilidou	PROPN
gs-4132	465	2	,	,	PUNCT
gs-4132	465	3	e.	e.	PROPN
gs-4132	465	4	,	,	PUNCT
gs-4132	465	5	melachroinou	melachroinou	NOUN
gs-4132	465	6	,	,	PUNCT
gs-4132	465	7	k.	k.	PROPN
gs-4132	465	8	,	,	PUNCT
gs-4132	465	9	roumeliotis	roumeliotis	PROPN
gs-4132	465	10	,	,	PUNCT
gs-4132	465	11	t.	t.	PROPN
gs-4132	465	12	,	,	PUNCT
gs-4132	465	13	garbis	garbis	PROPN
gs-4132	465	14	,	,	PUNCT
gs-4132	465	15	s.	s.	PROPN
gs-4132	465	16	d.	d.	PROPN
gs-4132	465	17	,	,	PUNCT
gs-4132	465	18	ntzouni	ntzouni	PROPN
gs-4132	465	19	,	,	PUNCT
gs-4132	465	20	m.	m.	NOUN
gs-4132	465	21	,	,	PUNCT
gs-4132	465	22	margaritis	margaritis	NOUN
gs-4132	465	23	,	,	PUNCT
gs-4132	465	24	l.	l.	PROPN
gs-4132	465	25	h.	h.	PROPN
gs-4132	465	26	,	,	PUNCT
gs-4132	465	27	&	&	CCONJ
gs-4132	465	28	vekrellis	vekrellis	PROPN
gs-4132	465	29	,	,	PUNCT
gs-4132	465	30	k.	k.	PROPN
gs-4132	465	31	(	(	PUNCT
gs-4132	465	32	2010	2010	NUM
gs-4132	465	33	)	)	PUNCT
gs-4132	465	34	.	.	PUNCT
gs-4132	466	1	cell	cell	NOUN
gs-4132	466	2	-	-	PUNCT
gs-4132	466	3	produced	produce	VERB
gs-4132	466	4	-synuclein	-synuclein	NOUN
gs-4132	466	5	is	be	AUX
gs-4132	466	6	secreted	secrete	VERB
gs-4132	466	7	in	in	ADP
gs-4132	466	8	a	a	DET
gs-4132	466	9	calcium	calcium	NOUN
gs-4132	466	10	-	-	PUNCT
gs-4132	466	11	dependent	dependent	ADJ
gs-4132	466	12	manner	manner	NOUN
gs-4132	466	13	by	by	ADP
gs-4132	466	14	exosomes	exosome	NOUN
gs-4132	466	15	and	and	CCONJ
gs-4132	466	16	impacts	impact	VERB
gs-4132	466	17	neuronal	neuronal	ADJ
gs-4132	466	18	survival	survival	NOUN
gs-4132	466	19	.	.	PUNCT
gs-4132	467	1	journal	journal	NOUN
gs-4132	467	2	of	of	ADP
gs-4132	467	3	neuroscience	neuroscience	NOUN
gs-4132	467	4	,	,	PUNCT
gs-4132	467	5	30(20	30(20	NUM
gs-4132	467	6	)	)	PUNCT
gs-4132	467	7	,	,	PUNCT
gs-4132	467	8	6838–6851	6838–6851	NOUN
gs-4132	467	9	.	.	PUNCT
gs-4132	468	1	elsabahy	elsabahy	PROPN
gs-4132	468	2	,	,	PUNCT
gs-4132	468	3	m.	m.	NOUN
gs-4132	468	4	,	,	PUNCT
gs-4132	468	5	&	&	CCONJ
gs-4132	468	6	wooley	wooley	PROPN
gs-4132	468	7	,	,	PUNCT
gs-4132	468	8	k.	k.	PROPN
gs-4132	468	9	l.	l.	PROPN
gs-4132	468	10	(	(	PUNCT
gs-4132	468	11	2012	2012	NUM
gs-4132	468	12	)	)	PUNCT
gs-4132	468	13	.	.	PUNCT
gs-4132	469	1	design	design	NOUN
gs-4132	469	2	of	of	ADP
gs-4132	469	3	polymeric	polymeric	ADJ
gs-4132	469	4	nanoparticles	nanoparticle	NOUN
gs-4132	469	5	for	for	ADP
gs-4132	469	6	biomedical	biomedical	ADJ
gs-4132	469	7	delivery	delivery	NOUN
gs-4132	469	8	applications	application	NOUN
gs-4132	469	9	.	.	PUNCT
gs-4132	470	1	chemical	chemical	ADJ
gs-4132	470	2	society	society	NOUN
gs-4132	470	3	reviews	review	NOUN
gs-4132	470	4	,	,	PUNCT
gs-4132	470	5	41(7	41(7	NOUN
gs-4132	470	6	)	)	PUNCT
gs-4132	470	7	,	,	PUNCT
gs-4132	470	8	2545–2561	2545–2561	NUM
gs-4132	470	9	.	.	PUNCT
gs-4132	471	1	gabizon	gabizon	PROPN
gs-4132	471	2	,	,	PUNCT
gs-4132	471	3	a.	a.	NOUN
gs-4132	471	4	,	,	PUNCT
gs-4132	471	5	shmeeda	shmeeda	PROPN
gs-4132	471	6	,	,	PUNCT
gs-4132	471	7	h.	h.	PROPN
gs-4132	471	8	,	,	PUNCT
gs-4132	471	9	&	&	CCONJ
gs-4132	471	10	barenholz	barenholz	PROPN
gs-4132	471	11	,	,	PUNCT
gs-4132	471	12	y.	y.	PROPN
gs-4132	471	13	(	(	PUNCT
gs-4132	471	14	1999	1999	NUM
gs-4132	471	15	)	)	PUNCT
gs-4132	471	16	.	.	PUNCT
gs-4132	472	1	pharmacokinetics	pharmacokinetic	NOUN
gs-4132	472	2	of	of	ADP
gs-4132	472	3	pegylated	pegylated	ADJ
gs-4132	472	4	liposomal	liposomal	ADJ
gs-4132	472	5	doxorubicin	doxorubicin	PROPN
gs-4132	472	6	:	:	PUNCT
gs-4132	472	7	review	review	NOUN
gs-4132	472	8	of	of	ADP
gs-4132	472	9	animal	animal	NOUN
gs-4132	472	10	and	and	CCONJ
gs-4132	472	11	human	human	ADJ
gs-4132	472	12	studies	study	NOUN
gs-4132	472	13	.	.	PUNCT
gs-4132	473	1	clinical	clinical	ADJ
gs-4132	473	2	pharmacokinetics	pharmacokinetic	NOUN
gs-4132	473	3	,	,	PUNCT
gs-4132	473	4	42(5	42(5	NUM
gs-4132	473	5	)	)	PUNCT
gs-4132	473	6	,	,	PUNCT
gs-4132	473	7	419–436	419–436	NUM
gs-4132	473	8	.	.	PUNCT
gs-4132	474	1	gan	gan	PROPN
gs-4132	474	2	,	,	PUNCT
gs-4132	474	3	l.	l.	PROPN
gs-4132	474	4	m.	m.	PROPN
gs-4132	474	5	,	,	PUNCT
gs-4132	474	6	lagerström	lagerström	NOUN
gs-4132	474	7	-	-	PUNCT
gs-4132	474	8	fermér	fermér	NOUN
gs-4132	474	9	,	,	PUNCT
gs-4132	474	10	m.	m.	NOUN
gs-4132	474	11	,	,	PUNCT
gs-4132	474	12	carlsson	carlsson	PROPN
gs-4132	474	13	,	,	PUNCT
gs-4132	474	14	l.	l.	PROPN
gs-4132	474	15	g.	g.	PROPN
gs-4132	474	16	,	,	PUNCT
gs-4132	474	17	arfvidsson	arfvidsson	PROPN
gs-4132	474	18	,	,	PUNCT
gs-4132	474	19	c.	c.	NOUN
gs-4132	474	20	,	,	PUNCT
gs-4132	474	21	egnell	egnell	NOUN
gs-4132	474	22	,	,	PUNCT
gs-4132	474	23	a.	a.	PROPN
gs-4132	474	24	c.	c.	PROPN
gs-4132	474	25	,	,	PUNCT
gs-4132	474	26	rudvik	rudvik	PROPN
gs-4132	474	27	,	,	PUNCT
gs-4132	474	28	a.	a.	NOUN
gs-4132	474	29	,	,	PUNCT
gs-4132	474	30	...	...	PUNCT
gs-4132	474	31	&	&	CCONJ
gs-4132	474	32	sylvén	sylvén	PROPN
gs-4132	474	33	,	,	PUNCT
gs-4132	474	34	c.	c.	PROPN
gs-4132	474	35	(	(	PUNCT
gs-4132	474	36	2021	2021	NUM
gs-4132	474	37	)	)	PUNCT
gs-4132	474	38	.	.	PUNCT
gs-4132	475	1	intradermal	intradermal	ADJ
gs-4132	475	2	delivery	delivery	NOUN
gs-4132	475	3	of	of	ADP
gs-4132	475	4	modified	modify	VERB
gs-4132	475	5	mrna	mrna	PROPN
gs-4132	475	6	encoding	encoding	PROPN
gs-4132	475	7	vegf	vegf	PROPN
gs-4132	475	8	-	-	PUNCT
gs-4132	475	9	a	a	PROPN
gs-4132	475	10	in	in	ADP
gs-4132	475	11	patients	patient	NOUN
gs-4132	475	12	with	with	ADP
gs-4132	475	13	type	type	NOUN
gs-4132	475	14	2	2	NUM
gs-4132	475	15	diabetes	diabetes	NOUN
gs-4132	475	16	.	.	PUNCT
gs-4132	476	1	nature	nature	NOUN
gs-4132	476	2	communications	communication	NOUN
gs-4132	476	3	,	,	PUNCT
gs-4132	476	4	12(1	12(1	NUM
gs-4132	476	5	)	)	PUNCT
gs-4132	476	6	,	,	PUNCT
gs-4132	476	7	871	871	NUM
gs-4132	476	8	.	.	PUNCT
gs-4132	477	1	georgian	georgian	NOUN
gs-4132	477	2	scientists/	scientists/	NUM
gs-4132	477	3	.	.	PUNCT
gs-4132	478	1	7	7	NUM
gs-4132	478	2	n	n	DET
gs-4132	478	3	4	4	NUM
gs-4132	478	4	,	,	PUNCT
gs-4132	478	5	2025	2025	NUM
gs-4132	478	6	27	27	NUM
gs-4132	478	7	garay	garay	NOUN
gs-4132	478	8	,	,	PUNCT
gs-4132	478	9	r.	r.	PROPN
gs-4132	478	10	p.	p.	PROPN
gs-4132	478	11	,	,	PUNCT
gs-4132	478	12	el	el	PROPN
gs-4132	478	13	-	-	ADJ
gs-4132	478	14	gewely	gewely	PROPN
gs-4132	478	15	,	,	PUNCT
gs-4132	478	16	r.	r.	PROPN
gs-4132	478	17	,	,	PUNCT
gs-4132	478	18	armstrong	armstrong	PROPN
gs-4132	478	19	,	,	PUNCT
gs-4132	478	20	j.	j.	PROPN
gs-4132	478	21	k.	k.	PROPN
gs-4132	478	22	,	,	PUNCT
gs-4132	478	23	garratty	garratty	PROPN
gs-4132	478	24	,	,	PUNCT
gs-4132	478	25	g.	g.	PROPN
gs-4132	478	26	,	,	PUNCT
gs-4132	478	27	&	&	CCONJ
gs-4132	478	28	richette	richette	PROPN
gs-4132	478	29	,	,	PUNCT
gs-4132	478	30	p.	p.	NOUN
gs-4132	478	31	(	(	PUNCT
gs-4132	478	32	2012	2012	NUM
gs-4132	478	33	)	)	PUNCT
gs-4132	478	34	.	.	PUNCT
gs-4132	479	1	antibodies	antibodie	VERB
gs-4132	479	2	against	against	ADP
gs-4132	479	3	polyethylene	polyethylene	NOUN
gs-4132	479	4	glycol	glycol	NOUN
gs-4132	479	5	in	in	ADP
gs-4132	479	6	healthy	healthy	ADJ
gs-4132	479	7	subjects	subject	NOUN
gs-4132	479	8	and	and	CCONJ
gs-4132	479	9	in	in	ADP
gs-4132	479	10	patients	patient	NOUN
gs-4132	479	11	treated	treat	VERB
gs-4132	479	12	with	with	ADP
gs-4132	479	13	peg	peg	NOUN
gs-4132	479	14	-	-	PUNCT
gs-4132	479	15	conjugated	conjugate	VERB
gs-4132	479	16	agents	agent	NOUN
gs-4132	479	17	.	.	PUNCT
gs-4132	480	1	expert	expert	ADJ
gs-4132	480	2	opinion	opinion	NOUN
gs-4132	480	3	on	on	ADP
gs-4132	480	4	drug	drug	NOUN
gs-4132	480	5	delivery	delivery	NOUN
gs-4132	480	6	,	,	PUNCT
gs-4132	480	7	9(11	9(11	NUM
gs-4132	480	8	)	)	PUNCT
gs-4132	480	9	,	,	PUNCT
gs-4132	480	10	1319–1323	1319–1323	NUM
gs-4132	480	11	.	.	PUNCT
gs-4132	481	1	gillies	gillie	NOUN
gs-4132	481	2	,	,	PUNCT
gs-4132	481	3	e.	e.	PROPN
gs-4132	481	4	r.	r.	PROPN
gs-4132	481	5	,	,	PUNCT
gs-4132	481	6	&	&	CCONJ
gs-4132	481	7	fréchet	fréchet	PROPN
gs-4132	481	8	,	,	PUNCT
gs-4132	481	9	j.	j.	PROPN
gs-4132	481	10	m.	m.	PROPN
gs-4132	481	11	(	(	PUNCT
gs-4132	481	12	2005	2005	NUM
gs-4132	481	13	)	)	PUNCT
gs-4132	481	14	.	.	PUNCT
gs-4132	482	1	dendrimers	dendrimer	NOUN
gs-4132	482	2	and	and	CCONJ
gs-4132	482	3	dendritic	dendritic	ADJ
gs-4132	482	4	polymers	polymer	NOUN
gs-4132	482	5	in	in	ADP
gs-4132	482	6	drug	drug	NOUN
gs-4132	482	7	delivery	delivery	NOUN
gs-4132	482	8	.	.	PUNCT
gs-4132	483	1	drug	drug	NOUN
gs-4132	483	2	discovery	discovery	PROPN
gs-4132	483	3	today	today	NOUN
gs-4132	483	4	,	,	PUNCT
gs-4132	483	5	10(1	10(1	NUM
gs-4132	483	6	)	)	PUNCT
gs-4132	483	7	,	,	PUNCT
gs-4132	483	8	35–43	35–43	NUM
gs-4132	483	9	.	.	PUNCT
gs-4132	484	1	gilligan	gilligan	PROPN
gs-4132	484	2	,	,	PUNCT
gs-4132	484	3	k.	k.	PROPN
gs-4132	484	4	e.	e.	PROPN
gs-4132	484	5	,	,	PUNCT
gs-4132	484	6	&	&	CCONJ
gs-4132	484	7	dwyer	dwyer	PROPN
gs-4132	484	8	,	,	PUNCT
gs-4132	484	9	r.	r.	PROPN
gs-4132	484	10	m.	m.	PROPN
gs-4132	484	11	(	(	PUNCT
gs-4132	484	12	2017	2017	NUM
gs-4132	484	13	)	)	PUNCT
gs-4132	484	14	.	.	PUNCT
gs-4132	485	1	engineering	engineering	NOUN
gs-4132	485	2	exosomes	exosome	NOUN
gs-4132	485	3	for	for	ADP
gs-4132	485	4	cancer	cancer	NOUN
gs-4132	485	5	therapy	therapy	NOUN
gs-4132	485	6	.	.	PUNCT
gs-4132	486	1	international	international	ADJ
gs-4132	486	2	journal	journal	NOUN
gs-4132	486	3	of	of	ADP
gs-4132	486	4	molecular	molecular	ADJ
gs-4132	486	5	sciences	science	NOUN
gs-4132	486	6	,	,	PUNCT
gs-4132	486	7	18(6	18(6	NOUN
gs-4132	486	8	)	)	PUNCT
gs-4132	486	9	,	,	PUNCT
gs-4132	486	10	1122	1122	NUM
gs-4132	486	11	.	.	PUNCT
gs-4132	487	1	gupta	gupta	PROPN
gs-4132	487	2	,	,	PUNCT
gs-4132	487	3	a.	a.	PROPN
gs-4132	487	4	k.	k.	PROPN
gs-4132	487	5	,	,	PUNCT
gs-4132	487	6	&	&	CCONJ
gs-4132	487	7	gupta	gupta	PROPN
gs-4132	487	8	,	,	PUNCT
gs-4132	487	9	m.	m.	NOUN
gs-4132	487	10	(	(	PUNCT
gs-4132	487	11	2005	2005	NUM
gs-4132	487	12	)	)	PUNCT
gs-4132	487	13	.	.	PUNCT
gs-4132	488	1	synthesis	synthesis	NOUN
gs-4132	488	2	and	and	CCONJ
gs-4132	488	3	surface	surface	NOUN
gs-4132	488	4	engineering	engineering	NOUN
gs-4132	488	5	of	of	ADP
gs-4132	488	6	iron	iron	NOUN
gs-4132	488	7	oxide	oxide	NOUN
gs-4132	488	8	nanoparticles	nanoparticle	NOUN
gs-4132	488	9	for	for	ADP
gs-4132	488	10	biomedical	biomedical	ADJ
gs-4132	488	11	applications	application	NOUN
gs-4132	488	12	.	.	PUNCT
gs-4132	489	1	biomaterials	biomaterial	NOUN
gs-4132	489	2	,	,	PUNCT
gs-4132	489	3	26(18	26(18	NOUN
gs-4132	489	4	)	)	PUNCT
gs-4132	489	5	,	,	PUNCT
gs-4132	489	6	3995–4021	3995–4021	NUM
gs-4132	489	7	.	.	PUNCT
gs-4132	490	1	györgy	györgy	PROPN
gs-4132	490	2	,	,	PUNCT
gs-4132	490	3	b.	b.	PROPN
gs-4132	490	4	,	,	PUNCT
gs-4132	490	5	szabó	szabó	PROPN
gs-4132	490	6	,	,	PUNCT
gs-4132	490	7	t.	t.	PROPN
gs-4132	490	8	g.	g.	PROPN
gs-4132	490	9	,	,	PUNCT
gs-4132	490	10	pásztói	pásztói	PROPN
gs-4132	490	11	,	,	PUNCT
gs-4132	490	12	m.	m.	NOUN
gs-4132	490	13	,	,	PUNCT
gs-4132	490	14	pál	pál	PROPN
gs-4132	490	15	,	,	PUNCT
gs-4132	490	16	z.	z.	PROPN
gs-4132	490	17	,	,	PUNCT
gs-4132	490	18	misják	misják	PROPN
gs-4132	490	19	,	,	PUNCT
gs-4132	490	20	p.	p.	NOUN
gs-4132	490	21	,	,	PUNCT
gs-4132	490	22	aradi	aradi	PROPN
gs-4132	490	23	,	,	PUNCT
gs-4132	490	24	b.	b.	PROPN
gs-4132	490	25	,	,	PUNCT
gs-4132	490	26	...	...	PUNCT
gs-4132	490	27	&	&	CCONJ
gs-4132	490	28	buzás	buzás	NOUN
gs-4132	490	29	,	,	PUNCT
gs-4132	490	30	e.	e.	PROPN
gs-4132	490	31	i.	i.	PROPN
gs-4132	490	32	(	(	PUNCT
gs-4132	490	33	2011	2011	NUM
gs-4132	490	34	)	)	PUNCT
gs-4132	490	35	.	.	PUNCT
gs-4132	491	1	membrane	membrane	NOUN
gs-4132	491	2	vesicles	vesicle	NOUN
gs-4132	491	3	,	,	PUNCT
gs-4132	491	4	current	current	ADJ
gs-4132	491	5	state	state	NOUN
gs-4132	491	6	-	-	PUNCT
gs-4132	491	7	of	of	ADP
gs-4132	491	8	-	-	PUNCT
gs-4132	491	9	the	the	DET
gs-4132	491	10	-	-	PUNCT
gs-4132	491	11	art	art	NOUN
gs-4132	491	12	:	:	PUNCT
gs-4132	491	13	emerging	emerge	VERB
gs-4132	491	14	role	role	NOUN
gs-4132	491	15	of	of	ADP
gs-4132	491	16	extracellular	extracellular	ADJ
gs-4132	491	17	vesicles	vesicle	NOUN
gs-4132	491	18	in	in	ADP
gs-4132	491	19	immune	immune	ADJ
gs-4132	491	20	modulation	modulation	NOUN
gs-4132	491	21	and	and	CCONJ
gs-4132	491	22	therapy	therapy	NOUN
gs-4132	491	23	.	.	PUNCT
gs-4132	492	1	cellular	cellular	ADJ
gs-4132	492	2	and	and	CCONJ
gs-4132	492	3	molecular	molecular	ADJ
gs-4132	492	4	life	life	NOUN
gs-4132	492	5	sciences	science	NOUN
gs-4132	492	6	,	,	PUNCT
gs-4132	492	7	68(16	68(16	NUM
gs-4132	492	8	)	)	PUNCT
gs-4132	492	9	,	,	PUNCT
gs-4132	492	10	2667	2667	NUM
gs-4132	492	11	–	–	PUNCT
gs-4132	492	12	2688	2688	NUM
gs-4132	492	13	.	.	PUNCT
gs-4132	493	1	helwa	helwa	PROPN
gs-4132	493	2	,	,	PUNCT
gs-4132	493	3	i.	i.	PROPN
gs-4132	493	4	,	,	PUNCT
gs-4132	493	5	cai	cai	PROPN
gs-4132	493	6	,	,	PUNCT
gs-4132	493	7	j.	j.	PROPN
gs-4132	493	8	,	,	PUNCT
gs-4132	493	9	drewry	drewry	NOUN
gs-4132	493	10	,	,	PUNCT
gs-4132	493	11	m.	m.	NOUN
gs-4132	493	12	d.	d.	PROPN
gs-4132	493	13	,	,	PUNCT
gs-4132	493	14	zimmerman	zimmerman	PROPN
gs-4132	493	15	,	,	PUNCT
gs-4132	493	16	a.	a.	PROPN
gs-4132	493	17	,	,	PUNCT
gs-4132	493	18	dinkins	dinkins	PROPN
gs-4132	493	19	,	,	PUNCT
gs-4132	493	20	m.	m.	PROPN
gs-4132	493	21	b.	b.	PROPN
gs-4132	493	22	,	,	PUNCT
gs-4132	493	23	khaled	khaled	PROPN
gs-4132	493	24	,	,	PUNCT
gs-4132	493	25	m.	m.	NOUN
gs-4132	493	26	l.	l.	PROPN
gs-4132	493	27	,	,	PUNCT
gs-4132	493	28	...	...	PUNCT
gs-4132	493	29	&	&	CCONJ
gs-4132	493	30	liu	liu	PROPN
gs-4132	493	31	,	,	PUNCT
gs-4132	493	32	y.	y.	PROPN
gs-4132	493	33	(	(	PUNCT
gs-4132	493	34	2017	2017	NUM
gs-4132	493	35	)	)	PUNCT
gs-4132	493	36	.	.	PUNCT
gs-4132	494	1	a	a	DET
gs-4132	494	2	comparative	comparative	ADJ
gs-4132	494	3	study	study	NOUN
gs-4132	494	4	of	of	ADP
gs-4132	494	5	serum	serum	NOUN
gs-4132	494	6	exosome	exosome	PROPN
gs-4132	494	7	isolation	isolation	NOUN
gs-4132	494	8	using	use	VERB
gs-4132	494	9	differential	differential	ADJ
gs-4132	494	10	ultracentrifugation	ultracentrifugation	NOUN
gs-4132	494	11	and	and	CCONJ
gs-4132	494	12	three	three	NUM
gs-4132	494	13	commercial	commercial	ADJ
gs-4132	494	14	reagents	reagent	NOUN
gs-4132	494	15	.	.	PUNCT
gs-4132	495	1	plos	plos	PROPN
gs-4132	495	2	one	one	NUM
gs-4132	495	3	,	,	PUNCT
gs-4132	495	4	12(1	12(1	NUM
gs-4132	495	5	)	)	PUNCT
gs-4132	495	6	,	,	PUNCT
gs-4132	495	7	e0170628	e0170628	PROPN
gs-4132	495	8	.	.	PUNCT
gs-4132	496	1	holst	holst	NOUN
gs-4132	496	2	,	,	PUNCT
gs-4132	496	3	j.	j.	PROPN
gs-4132	496	4	,	,	PUNCT
gs-4132	496	5	martin	martin	PROPN
gs-4132	496	6	,	,	PUNCT
gs-4132	496	7	d.	d.	PROPN
gs-4132	496	8	,	,	PUNCT
gs-4132	496	9	arnold	arnold	PROPN
gs-4132	496	10	,	,	PUNCT
gs-4132	496	11	r.	r.	PROPN
gs-4132	496	12	,	,	PUNCT
gs-4132	496	13	huergo	huergo	PROPN
gs-4132	496	14	,	,	PUNCT
gs-4132	496	15	c.	c.	PROPN
gs-4132	496	16	c.	c.	PROPN
gs-4132	496	17	,	,	PUNCT
gs-4132	496	18	oster	oster	NOUN
gs-4132	496	19	,	,	PUNCT
gs-4132	496	20	p.	p.	PROPN
gs-4132	496	21	,	,	PUNCT
gs-4132	496	22	o’hallahan	o’hallahan	PROPN
gs-4132	496	23	,	,	PUNCT
gs-4132	496	24	j.	j.	PROPN
gs-4132	496	25	,	,	PUNCT
gs-4132	496	26	&	&	CCONJ
gs-4132	496	27	rosenqvist	rosenqvist	PROPN
gs-4132	496	28	,	,	PUNCT
gs-4132	496	29	e.	e.	PROPN
gs-4132	496	30	(	(	PUNCT
gs-4132	496	31	2009	2009	NUM
gs-4132	496	32	)	)	PUNCT
gs-4132	496	33	.	.	PUNCT
gs-4132	497	1	properties	property	NOUN
gs-4132	497	2	and	and	CCONJ
gs-4132	497	3	clinical	clinical	ADJ
gs-4132	497	4	performance	performance	NOUN
gs-4132	497	5	of	of	ADP
gs-4132	497	6	vaccines	vaccine	NOUN
gs-4132	497	7	containing	contain	VERB
gs-4132	497	8	outer	outer	ADJ
gs-4132	497	9	membrane	membrane	NOUN
gs-4132	497	10	vesicles	vesicle	NOUN
gs-4132	497	11	from	from	ADP
gs-4132	497	12	neisseria	neisseria	PROPN
gs-4132	497	13	meningitidis	meningitidis	PROPN
gs-4132	497	14	.	.	PUNCT
gs-4132	498	1	vaccine	vaccine	NOUN
gs-4132	498	2	,	,	PUNCT
gs-4132	498	3	27(suppl	27(suppl	ADJ
gs-4132	498	4	2	2	NUM
gs-4132	498	5	)	)	PUNCT
gs-4132	498	6	,	,	PUNCT
gs-4132	498	7	b3	b3	PROPN
gs-4132	498	8	–	–	PUNCT
gs-4132	498	9	b12	b12	NOUN
gs-4132	498	10	.	.	PUNCT
gs-4132	499	1	hoshino	hoshino	PROPN
gs-4132	499	2	,	,	PUNCT
gs-4132	499	3	a.	a.	PROPN
gs-4132	499	4	,	,	PUNCT
gs-4132	499	5	costa	costa	PROPN
gs-4132	499	6	-	-	PUNCT
gs-4132	499	7	silva	silva	PROPN
gs-4132	499	8	,	,	PUNCT
gs-4132	499	9	b.	b.	PROPN
gs-4132	499	10	,	,	PUNCT
gs-4132	499	11	shen	shen	PROPN
gs-4132	499	12	,	,	PUNCT
gs-4132	499	13	t.	t.	PROPN
gs-4132	499	14	l.	l.	PROPN
gs-4132	499	15	,	,	PUNCT
gs-4132	499	16	rodrigues	rodrigues	PROPN
gs-4132	499	17	,	,	PUNCT
gs-4132	499	18	g.	g.	PROPN
gs-4132	499	19	,	,	PUNCT
gs-4132	499	20	hashimoto	hashimoto	NOUN
gs-4132	499	21	,	,	PUNCT
gs-4132	499	22	a.	a.	NOUN
gs-4132	499	23	,	,	PUNCT
gs-4132	499	24	tesic	tesic	NOUN
gs-4132	499	25	mark	mark	NOUN
gs-4132	499	26	,	,	PUNCT
gs-4132	499	27	m.	m.	NOUN
gs-4132	499	28	,	,	PUNCT
gs-4132	499	29	...	...	PUNCT
gs-4132	499	30	&	&	CCONJ
gs-4132	499	31	lyden	lyden	PROPN
gs-4132	499	32	,	,	PUNCT
gs-4132	499	33	d.	d.	PROPN
gs-4132	499	34	(	(	PUNCT
gs-4132	499	35	2015	2015	NUM
gs-4132	499	36	)	)	PUNCT
gs-4132	499	37	.	.	PUNCT
gs-4132	500	1	tumour	tumour	NOUN
gs-4132	500	2	exosome	exosome	PROPN
gs-4132	500	3	integrins	integrin	NOUN
gs-4132	500	4	determine	determine	VERB
gs-4132	500	5	organotropic	organotropic	ADJ
gs-4132	500	6	metastasis	metastasis	NOUN
gs-4132	500	7	.	.	PUNCT
gs-4132	501	1	nature	nature	NOUN
gs-4132	501	2	,	,	PUNCT
gs-4132	501	3	527(7578	527(7578	NUM
gs-4132	501	4	)	)	PUNCT
gs-4132	501	5	,	,	PUNCT
gs-4132	501	6	329–335	329–335	NUM
gs-4132	501	7	.	.	PUNCT