id	sid	tid	token	lemma	pos
gs-4267	1	1	fullpdf070412025.pdf	fullpdf070412025.pdf	VERB
gs-4267	1	2	the	the	DET
gs-4267	1	3	importance	importance	NOUN
gs-4267	1	4	of	of	ADP
gs-4267	1	5	hyperlactatemia	hyperlactatemia	ADV
gs-4267	1	6	in	in	ADP
gs-4267	1	7	the	the	DET
gs-4267	1	8	outcome	outcome	NOUN
gs-4267	1	9	of	of	ADP
gs-4267	1	10	sepsis	sepsis	NOUN
gs-4267	1	11	and	and	CCONJ
gs-4267	1	12	septic	septic	ADJ
gs-4267	1	13	shock	shock	NOUN
gs-4267	1	14	tinatin	tinatin	ADJ
gs-4267	1	15	gaphrindashvili	gaphrindashvili	NOUN
gs-4267	1	16	,	,	PUNCT
gs-4267	1	17	ramaz	ramaz	VERB
gs-4267	1	18	kalandadze	kalandadze	PROPN
gs-4267	1	19	intensive	intensive	ADJ
gs-4267	1	20	care	care	NOUN
gs-4267	1	21	unit	unit	NOUN
gs-4267	1	22	,	,	PUNCT
gs-4267	1	23	the	the	DET
gs-4267	1	24	first	first	ADJ
gs-4267	1	25	university	university	NOUN
gs-4267	1	26	clinic	clinic	NOUN
gs-4267	1	27	,	,	PUNCT
gs-4267	1	28	tbilisi	tbilisi	PROPN
gs-4267	1	29	state	state	PROPN
gs-4267	1	30	medical	medical	PROPN
gs-4267	1	31	university	university	PROPN
gs-4267	1	32	,	,	PUNCT
gs-4267	1	33	tbilisi	tbilisi	PROPN
gs-4267	1	34	,	,	PUNCT
gs-4267	1	35	georgia	georgia	PROPN
gs-4267	1	36	sepsis	sepsis	NOUN
gs-4267	1	37	and	and	CCONJ
gs-4267	1	38	septic	septic	ADJ
gs-4267	1	39	shock	shock	NOUN
gs-4267	1	40	are	be	AUX
gs-4267	1	41	leading	lead	VERB
gs-4267	1	42	causes	cause	NOUN
gs-4267	1	43	of	of	ADP
gs-4267	1	44	morbidity	morbidity	NOUN
gs-4267	1	45	and	and	CCONJ
gs-4267	1	46	mortality	mortality	NOUN
gs-4267	1	47	in	in	ADP
gs-4267	1	48	intensive	intensive	ADJ
gs-4267	1	49	care	care	NOUN
gs-4267	1	50	units	unit	NOUN
gs-4267	1	51	worldwide	worldwide	ADV
gs-4267	1	52	.	.	PUNCT
gs-4267	2	1	hyperlactatemia	hyperlactatemia	ADV
gs-4267	2	2	,	,	PUNCT
gs-4267	2	3	defined	define	VERB
gs-4267	2	4	as	as	ADP
gs-4267	2	5	elevated	elevate	VERB
gs-4267	2	6	serum	serum	NOUN
gs-4267	2	7	lactate	lactate	NOUN
gs-4267	2	8	levels	level	NOUN
gs-4267	2	9	,	,	PUNCT
gs-4267	2	10	is	be	AUX
gs-4267	2	11	frequently	frequently	ADV
gs-4267	2	12	observed	observe	VERB
gs-4267	2	13	in	in	ADP
gs-4267	2	14	these	these	DET
gs-4267	2	15	conditions	condition	NOUN
gs-4267	2	16	and	and	CCONJ
gs-4267	2	17	serves	serve	VERB
gs-4267	2	18	as	as	ADP
gs-4267	2	19	both	both	CCONJ
gs-4267	2	20	a	a	DET
gs-4267	2	21	biomarker	biomarker	NOUN
gs-4267	2	22	and	and	CCONJ
gs-4267	2	23	mediator	mediator	NOUN
gs-4267	2	24	of	of	ADP
gs-4267	2	25	disease	disease	NOUN
gs-4267	2	26	severity	severity	NOUN
gs-4267	2	27	.	.	PUNCT
gs-4267	3	1	lactate	lactate	NOUN
gs-4267	3	2	accumulation	accumulation	NOUN
gs-4267	3	3	reflects	reflect	VERB
gs-4267	3	4	an	an	DET
gs-4267	3	5	imbalance	imbalance	NOUN
gs-4267	3	6	between	between	ADP
gs-4267	3	7	production	production	NOUN
gs-4267	3	8	and	and	CCONJ
gs-4267	3	9	clearance	clearance	NOUN
gs-4267	3	10	,	,	PUNCT
gs-4267	3	11	often	often	ADV
gs-4267	3	12	indicating	indicate	VERB
gs-4267	3	13	tissue	tissue	NOUN
gs-4267	3	14	hypoperfusion	hypoperfusion	NOUN
gs-4267	3	15	,	,	PUNCT
gs-4267	3	16	mitochondrial	mitochondrial	ADJ
gs-4267	3	17	dysfunction	dysfunction	NOUN
gs-4267	3	18	,	,	PUNCT
gs-4267	3	19	and	and	CCONJ
gs-4267	3	20	catecholamine	catecholamine	NOUN
gs-4267	3	21	-	-	PUNCT
gs-4267	3	22	driven	drive	VERB
gs-4267	3	23	metabolic	metabolic	NOUN
gs-4267	3	24	alterations	alteration	NOUN
gs-4267	3	25	.	.	PUNCT
gs-4267	4	1	understanding	understand	VERB
gs-4267	4	2	its	its	PRON
gs-4267	4	3	pathophysiological	pathophysiological	ADJ
gs-4267	4	4	role	role	NOUN
gs-4267	4	5	is	be	AUX
gs-4267	4	6	crucial	crucial	ADJ
gs-4267	4	7	for	for	ADP
gs-4267	4	8	prognosis	prognosis	NOUN
gs-4267	4	9	and	and	CCONJ
gs-4267	4	10	therapeutic	therapeutic	ADJ
gs-4267	4	11	management	management	NOUN
gs-4267	4	12	.	.	PUNCT
gs-4267	5	1	this	this	DET
gs-4267	5	2	abstract	abstract	ADJ
gs-4267	5	3	reviews	review	VERB
gs-4267	5	4	current	current	ADJ
gs-4267	5	5	evidence	evidence	NOUN
gs-4267	5	6	on	on	ADP
gs-4267	5	7	the	the	DET
gs-4267	5	8	mechanisms	mechanism	NOUN
gs-4267	5	9	of	of	ADP
gs-4267	5	10	hyperlactatemia	hyperlactatemia	ADV
gs-4267	5	11	in	in	ADP
gs-4267	5	12	sepsis	sepsis	NOUN
gs-4267	5	13	and	and	CCONJ
gs-4267	5	14	septic	septic	ADJ
gs-4267	5	15	shock	shock	NOUN
gs-4267	5	16	,	,	PUNCT
gs-4267	5	17	highlighting	highlight	VERB
gs-4267	5	18	its	its	PRON
gs-4267	5	19	clinical	clinical	ADJ
gs-4267	5	20	implications	implication	NOUN
gs-4267	5	21	and	and	CCONJ
gs-4267	5	22	impact	impact	NOUN
gs-4267	5	23	on	on	ADP
gs-4267	5	24	patient	patient	ADJ
gs-4267	5	25	outcomes	outcome	NOUN
gs-4267	5	26	.	.	PUNCT
gs-4267	6	1	increased	increase	VERB
gs-4267	6	2	lactate	lactate	NOUN
gs-4267	6	3	production	production	NOUN
gs-4267	6	4	primarily	primarily	ADV
gs-4267	6	5	occurs	occur	VERB
gs-4267	6	6	through	through	ADP
gs-4267	6	7	anaerobic	anaerobic	NOUN
gs-4267	6	8	glycolysis	glycolysis	NOUN
gs-4267	6	9	caused	cause	VERB
gs-4267	6	10	by	by	ADP
gs-4267	6	11	tissue	tissue	NOUN
gs-4267	6	12	hypoperfusion	hypoperfusion	NOUN
gs-4267	6	13	,	,	PUNCT
gs-4267	6	14	while	while	SCONJ
gs-4267	6	15	catecholamine	catecholamine	NOUN
gs-4267	6	16	-	-	PUNCT
gs-4267	6	17	stimulated	stimulate	VERB
gs-4267	6	18	aerobic	aerobic	ADJ
gs-4267	6	19	glycolysis	glycolysis	NOUN
gs-4267	6	20	may	may	AUX
gs-4267	6	21	further	far	ADV
gs-4267	6	22	elevate	elevate	VERB
gs-4267	6	23	lactate	lactate	NOUN
gs-4267	6	24	levels	level	NOUN
gs-4267	6	25	.	.	PUNCT
gs-4267	7	1	impaired	impaired	ADJ
gs-4267	7	2	clearance	clearance	NOUN
gs-4267	7	3	,	,	PUNCT
gs-4267	7	4	mainly	mainly	ADV
gs-4267	7	5	due	due	ADP
gs-4267	7	6	to	to	ADP
gs-4267	7	7	hepatic	hepatic	ADJ
gs-4267	7	8	and	and	CCONJ
gs-4267	7	9	renal	renal	ADJ
gs-4267	7	10	dysfunction	dysfunction	NOUN
gs-4267	7	11	,	,	PUNCT
gs-4267	7	12	exacerbates	exacerbate	VERB
gs-4267	7	13	accumulation	accumulation	NOUN
gs-4267	7	14	.	.	PUNCT
gs-4267	8	1	inflammatory	inflammatory	ADJ
gs-4267	8	2	cytokines	cytokine	NOUN
gs-4267	8	3	and	and	CCONJ
gs-4267	8	4	mitochondrial	mitochondrial	ADJ
gs-4267	8	5	impairment	impairment	NOUN
gs-4267	8	6	contribute	contribute	VERB
gs-4267	8	7	to	to	ADP
gs-4267	8	8	metabolic	metabolic	NOUN
gs-4267	8	9	dysregulation	dysregulation	NOUN
gs-4267	8	10	.	.	PUNCT
gs-4267	9	1	clinically	clinically	ADV
gs-4267	9	2	,	,	PUNCT
gs-4267	9	3	elevated	elevated	ADJ
gs-4267	9	4	lactate	lactate	NOUN
gs-4267	9	5	is	be	AUX
gs-4267	9	6	strongly	strongly	ADV
gs-4267	9	7	associated	associate	VERB
gs-4267	9	8	with	with	ADP
gs-4267	9	9	organ	organ	NOUN
gs-4267	9	10	dysfunction	dysfunction	NOUN
gs-4267	9	11	and	and	CCONJ
gs-4267	9	12	increased	increase	VERB
gs-4267	9	13	mortality	mortality	NOUN
gs-4267	9	14	.	.	PUNCT
gs-4267	10	1	serial	serial	ADJ
gs-4267	10	2	lactate	lactate	NOUN
gs-4267	10	3	measurements	measurement	NOUN
gs-4267	10	4	provide	provide	VERB
gs-4267	10	5	valuable	valuable	ADJ
gs-4267	10	6	information	information	NOUN
gs-4267	10	7	for	for	ADP
gs-4267	10	8	guiding	guide	VERB
gs-4267	10	9	resuscitation	resuscitation	NOUN
gs-4267	10	10	and	and	CCONJ
gs-4267	10	11	therapeutic	therapeutic	ADJ
gs-4267	10	12	interventions	intervention	NOUN
gs-4267	10	13	,	,	PUNCT
gs-4267	10	14	including	include	VERB
gs-4267	10	15	fluid	fluid	ADJ
gs-4267	10	16	management	management	NOUN
gs-4267	10	17	,	,	PUNCT
gs-4267	10	18	vasopressor	vasopressor	NOUN
gs-4267	10	19	administration	administration	NOUN
gs-4267	10	20	and	and	CCONJ
gs-4267	10	21	optimization	optimization	NOUN
gs-4267	10	22	of	of	ADP
gs-4267	10	23	tissue	tissue	NOUN
gs-4267	10	24	oxygen	oxygen	NOUN
gs-4267	10	25	delivery	delivery	NOUN
gs-4267	10	26	.	.	PUNCT
gs-4267	11	1	early	early	ADJ
gs-4267	11	2	recognition	recognition	NOUN
gs-4267	11	3	of	of	ADP
gs-4267	11	4	hyperlactatemia	hyperlactatemia	ADV
gs-4267	11	5	and	and	CCONJ
gs-4267	11	6	targeted	target	VERB
gs-4267	11	7	interventions	intervention	NOUN
gs-4267	11	8	based	base	VERB
gs-4267	11	9	on	on	ADP
gs-4267	11	10	lactate	lactate	NOUN
gs-4267	11	11	trends	trend	NOUN
gs-4267	11	12	can	can	AUX
gs-4267	11	13	improve	improve	VERB
gs-4267	11	14	outcomes	outcome	NOUN
gs-4267	11	15	,	,	PUNCT
gs-4267	11	16	reduce	reduce	VERB
gs-4267	11	17	complications	complication	NOUN
gs-4267	11	18	,	,	PUNCT
gs-4267	11	19	and	and	CCONJ
gs-4267	11	20	support	support	VERB
gs-4267	11	21	individualized	individualize	VERB
gs-4267	11	22	critical	critical	ADJ
gs-4267	11	23	care	care	NOUN
gs-4267	11	24	strategies	strategy	NOUN
gs-4267	11	25	.	.	PUNCT
gs-4267	12	1	in	in	ADP
gs-4267	12	2	conclusion	conclusion	NOUN
gs-4267	12	3	,	,	PUNCT
gs-4267	12	4	hyperlactatemia	hyperlactatemia	ADV
gs-4267	12	5	is	be	AUX
gs-4267	12	6	a	a	DET
gs-4267	12	7	key	key	ADJ
gs-4267	12	8	marker	marker	NOUN
gs-4267	12	9	in	in	ADP
gs-4267	12	10	the	the	DET
gs-4267	12	11	pathogenesis	pathogenesis	NOUN
gs-4267	12	12	and	and	CCONJ
gs-4267	12	13	progression	progression	NOUN
gs-4267	12	14	of	of	ADP
gs-4267	12	15	sepsis	sepsis	NOUN
gs-4267	12	16	and	and	CCONJ
gs-4267	12	17	septic	septic	ADJ
gs-4267	12	18	shock	shock	NOUN
gs-4267	12	19	.	.	PUNCT
gs-4267	13	1	it	it	PRON
gs-4267	13	2	reflects	reflect	VERB
gs-4267	13	3	underlying	underlie	VERB
gs-4267	13	4	metabolic	metabolic	NOUN
gs-4267	13	5	derangements	derangement	NOUN
gs-4267	13	6	,	,	PUNCT
gs-4267	13	7	tissue	tissue	NOUN
gs-4267	13	8	hypoxia	hypoxia	NOUN
gs-4267	13	9	and	and	CCONJ
gs-4267	13	10	impaired	impaired	ADJ
gs-4267	13	11	oxygen	oxygen	NOUN
gs-4267	13	12	utilization	utilization	NOUN
gs-4267	13	13	,	,	PUNCT
gs-4267	13	14	contributing	contribute	VERB
gs-4267	13	15	to	to	PART
gs-4267	13	16	multi	multi	ADJ
gs-4267	13	17	-	-	ADJ
gs-4267	13	18	organ	organ	ADJ
gs-4267	13	19	dysfunction	dysfunction	NOUN
gs-4267	13	20	.	.	PUNCT
gs-4267	14	1	monitoring	monitor	VERB
gs-4267	14	2	lactate	lactate	NOUN
gs-4267	14	3	levels	level	NOUN
gs-4267	14	4	and	and	CCONJ
gs-4267	14	5	promoting	promote	VERB
gs-4267	14	6	lactate	lactate	NOUN
gs-4267	14	7	clearance	clearance	NOUN
gs-4267	14	8	are	be	AUX
gs-4267	14	9	essential	essential	ADJ
gs-4267	14	10	for	for	ADP
gs-4267	14	11	effective	effective	ADJ
gs-4267	14	12	resuscitation	resuscitation	NOUN
gs-4267	14	13	and	and	CCONJ
gs-4267	14	14	patient	patient	ADJ
gs-4267	14	15	management	management	NOUN
gs-4267	14	16	.	.	PUNCT
gs-4267	15	1	a	a	DET
gs-4267	15	2	comprehensive	comprehensive	ADJ
gs-4267	15	3	understanding	understanding	NOUN
gs-4267	15	4	of	of	ADP
gs-4267	15	5	hyperlactatemia	hyperlactatemia	ADV
gs-4267	15	6	allows	allow	VERB
gs-4267	15	7	clinicians	clinician	NOUN
gs-4267	15	8	to	to	PART
gs-4267	15	9	implement	implement	VERB
gs-4267	15	10	timely	timely	ADJ
gs-4267	15	11	interventions	intervention	NOUN
gs-4267	15	12	,	,	PUNCT
gs-4267	15	13	optimize	optimize	NOUN
gs-4267	15	14	perfusion	perfusion	NOUN
gs-4267	15	15	,	,	PUNCT
gs-4267	15	16	and	and	CCONJ
gs-4267	15	17	improve	improve	VERB
gs-4267	15	18	prognosis	prognosis	NOUN
gs-4267	15	19	in	in	ADP
gs-4267	15	20	critically	critically	ADV
gs-4267	15	21	ill	ill	ADJ
gs-4267	15	22	patients	patient	NOUN
gs-4267	15	23	.	.	PUNCT
gs-4267	16	1	keywords	keyword	NOUN
gs-4267	16	2	:	:	PUNCT
gs-4267	16	3	hyperlactatemia	hyperlactatemia	ADV
gs-4267	16	4	,	,	PUNCT
gs-4267	16	5	sepsis	sepsis	NOUN
gs-4267	16	6	,	,	PUNCT
gs-4267	16	7	septic	septic	ADJ
gs-4267	16	8	shock	shock	NOUN
gs-4267	16	9	,	,	PUNCT
gs-4267	16	10	lactate	lactate	NOUN
gs-4267	16	11	clearance	clearance	NOUN
gs-4267	16	12	,	,	PUNCT
gs-4267	16	13	prognosis	prognosis	NOUN
gs-4267	16	14	.	.	PUNCT