id	sid	tid	token	lemma	pos
gs-4321	1	1	georgian	georgian	PROPN
gs-4321	1	2	scientists/	scientists/	NUM
gs-4321	1	3	.	.	PUNCT
gs-4321	2	1	7	7	NUM
gs-4321	2	2	n	n	DET
gs-4321	2	3	4	4	NUM
gs-4321	2	4	,	,	PUNCT
gs-4321	2	5	2025	2025	NUM
gs-4321	2	6	333	333	NUM
gs-4321	2	7	georgian	georgian	PROPN
gs-4321	2	8	scientists	scientist	NOUN
gs-4321	2	9	vol	vol	NOUN
gs-4321	2	10	.	.	PUNCT
gs-4321	2	11	7	7	NUM
gs-4321	2	12	issue	issue	NOUN
gs-4321	2	13	4	4	NUM
gs-4321	2	14	,	,	PUNCT
gs-4321	2	15	2025	2025	NUM
gs-4321	2	16	https://doi.org/10.52340/gs.2025.07.04.18	https://doi.org/10.52340/gs.2025.07.04.18	PROPN
gs-4321	2	17	bioinformatics	bioinformatics	NOUN
gs-4321	2	18	approaches	approach	NOUN
gs-4321	2	19	for	for	ADP
gs-4321	2	20	multi	multi	ADJ
gs-4321	2	21	-	-	ADJ
gs-4321	2	22	omics	omics	ADJ
gs-4321	2	23	analysis	analysis	NOUN
gs-4321	2	24	of	of	ADP
gs-4321	2	25	the	the	DET
gs-4321	2	26	tumor	tumor	NOUN
gs-4321	2	27	microenvironment	microenvironment	NOUN
gs-4321	2	28	:	:	PUNCT
gs-4321	2	29	integrating	integrate	VERB
gs-4321	2	30	proteomics	proteomic	NOUN
gs-4321	2	31	,	,	PUNCT
gs-4321	2	32	exosomes	exosome	NOUN
gs-4321	2	33	and	and	CCONJ
gs-4321	2	34	immune	immune	ADJ
gs-4321	2	35	signaling	signal	VERB
gs-4321	2	36	nodar	nodar	ADJ
gs-4321	2	37	sulashvili1	sulashvili1	PROPN
gs-4321	2	38	,	,	PUNCT
gs-4321	2	39	irina	irina	PROPN
gs-4321	2	40	imerlishvili2	imerlishvili2	PROPN
gs-4321	2	41	,	,	PUNCT
gs-4321	2	42	seyran	seyran	PROPN
gs-4321	2	43	kocharyan3	kocharyan3	PROPN
gs-4321	2	44	,	,	PUNCT
gs-4321	2	45	luiza	luiza	PROPN
gs-4321	2	46	gabunia4	gabunia4	PROPN
gs-4321	2	47	,	,	PUNCT
gs-4321	2	48	nana	nana	PROPN
gs-4321	2	49	gorgaslidze5	gorgaslidze5	PROPN
gs-4321	2	50	,	,	PUNCT
gs-4321	2	51	maka	maka	PROPN
gs-4321	2	52	buleishvili6	buleishvili6	PROPN
gs-4321	2	53	,	,	PUNCT
gs-4321	2	54	rajkaran	rajkaran	NOUN
gs-4321	2	55	singh7	singh7	NOUN
gs-4321	2	56	,	,	PUNCT
gs-4321	2	57	irine	irine	PROPN
gs-4321	2	58	zarnadze8	zarnadze8	PROPN
gs-4321	2	59	,	,	PUNCT
gs-4321	2	60	shalva	shalva	PROPN
gs-4321	2	61	(	(	PUNCT
gs-4321	2	62	davit	davit	NOUN
gs-4321	2	63	)	)	PUNCT
gs-4321	2	64	zarnadze9	zarnadze9	PROPN
gs-4321	2	65	,	,	PUNCT
gs-4321	2	66	david	david	PROPN
gs-4321	2	67	aphkhazava10	aphkhazava10	PROPN
gs-4321	2	68	1md	1md	NOUN
gs-4321	2	69	,	,	PUNCT
gs-4321	2	70	phd	phd	NOUN
gs-4321	2	71	,	,	PUNCT
gs-4321	2	72	doctor	doctor	NOUN
gs-4321	2	73	of	of	ADP
gs-4321	2	74	pharmaceutical	pharmaceutical	ADJ
gs-4321	2	75	and	and	CCONJ
gs-4321	2	76	pharmacological	pharmacological	ADJ
gs-4321	2	77	sciences	science	NOUN
gs-4321	2	78	in	in	ADP
gs-4321	2	79	medicine	medicine	NOUN
gs-4321	2	80	,	,	PUNCT
gs-4321	2	81	professor	professor	NOUN
gs-4321	2	82	of	of	ADP
gs-4321	2	83	medical	medical	ADJ
gs-4321	2	84	pharmacology	pharmacology	NOUN
gs-4321	2	85	of	of	ADP
gs-4321	2	86	faculty	faculty	NOUN
gs-4321	2	87	of	of	ADP
gs-4321	2	88	medicine	medicine	NOUN
gs-4321	2	89	at	at	ADP
gs-4321	2	90	georgian	georgian	PROPN
gs-4321	2	91	national	national	PROPN
gs-4321	2	92	university	university	PROPN
gs-4321	2	93	seu	seu	NOUN
gs-4321	2	94	;	;	PUNCT
gs-4321	2	95	orcid	orcid	PROPN
gs-4321	2	96	https://orcid.org/00000002-9005-8577	https://orcid.org/00000002-9005-8577	NOUN
gs-4321	2	97	;	;	PUNCT
gs-4321	2	98	e	e	X
gs-4321	2	99	-	-	NOUN
gs-4321	2	100	mail	mail	NOUN
gs-4321	2	101	:	:	PUNCT
gs-4321	2	102	n.sulashvili@ug.edu.ge;v2phd	n.sulashvili@ug.edu.ge;v2phd	NOUN
gs-4321	2	103	,	,	PUNCT
gs-4321	2	104	doctor	doctor	NOUN
gs-4321	2	105	of	of	ADP
gs-4321	2	106	law	law	NOUN
gs-4321	2	107	,	,	PUNCT
gs-4321	2	108	professor	professor	NOUN
gs-4321	2	109	,	,	PUNCT
gs-4321	2	110	rector	rector	NOUN
gs-4321	2	111	of	of	ADP
gs-4321	2	112	bau	bau	PROPN
gs-4321	2	113	international	international	PROPN
gs-4321	2	114	university	university	PROPN
gs-4321	2	115	batumi	batumi	NOUN
gs-4321	2	116	;	;	PUNCT
gs-4321	2	117	professor	professor	NOUN
gs-4321	2	118	at	at	ADP
gs-4321	2	119	the	the	DET
gs-4321	2	120	international	international	ADJ
gs-4321	2	121	black	black	PROPN
gs-4321	2	122	sea	sea	PROPN
gs-4321	2	123	university	university	NOUN
gs-4321	2	124	,	,	PUNCT
gs-4321	2	125	batumi	batumi	NOUN
gs-4321	2	126	-	-	PUNCT
gs-4321	2	127	tbilisi	tbilisi	ADJ
gs-4321	2	128	,	,	PUNCT
gs-4321	2	129	georgia	georgia	PROPN
gs-4321	2	130	;	;	PUNCT
gs-4321	2	131	3phd	3phd	NUM
gs-4321	2	132	,	,	PUNCT
gs-4321	2	133	doctor	doctor	NOUN
gs-4321	2	134	of	of	ADP
gs-4321	2	135	biology	biology	NOUN
gs-4321	2	136	,	,	PUNCT
gs-4321	2	137	professor	professor	NOUN
gs-4321	2	138	,	,	PUNCT
gs-4321	2	139	head	head	NOUN
gs-4321	2	140	of	of	ADP
gs-4321	2	141	science	science	NOUN
gs-4321	2	142	division	division	NOUN
gs-4321	2	143	of	of	ADP
gs-4321	2	144	yerevan	yerevan	PROPN
gs-4321	2	145	state	state	PROPN
gs-4321	2	146	medical	medical	PROPN
gs-4321	2	147	university	university	PROPN
gs-4321	2	148	after	after	ADP
gs-4321	2	149	mkhitar	mkhitar	NOUN
gs-4321	2	150	heratsi	heratsi	PROPN
gs-4321	2	151	,	,	PUNCT
gs-4321	2	152	head	head	NOUN
gs-4321	2	153	of	of	ADP
gs-4321	2	154	the	the	DET
gs-4321	2	155	department	department	PROPN
gs-4321	2	156	of	of	ADP
gs-4321	2	157	medical	medical	ADJ
gs-4321	2	158	physics	physics	PROPN
gs-4321	2	159	at	at	ADP
gs-4321	2	160	yerevan	yerevan	PROPN
gs-4321	2	161	state	state	PROPN
gs-4321	2	162	medical	medical	PROPN
gs-4321	2	163	university	university	PROPN
gs-4321	2	164	after	after	ADP
gs-4321	2	165	mkhitar	mkhitar	NOUN
gs-4321	2	166	heratsi	heratsi	PROPN
gs-4321	2	167	,	,	PUNCT
gs-4321	2	168	yerevan	yerevan	PROPN
gs-4321	2	169	,	,	PUNCT
gs-4321	2	170	armenia	armenia	PROPN
gs-4321	2	171	;	;	PUNCT
gs-4321	2	172	https://orcid.org/0009-0000-0322-9845	https://orcid.org/0009-0000-0322-9845	PROPN
gs-4321	2	173	4md	4md	NOUN
gs-4321	2	174	,	,	PUNCT
gs-4321	2	175	phd	phd	NOUN
gs-4321	2	176	,	,	PUNCT
gs-4321	2	177	doctor	doctor	NOUN
gs-4321	2	178	of	of	ADP
gs-4321	2	179	medical	medical	ADJ
gs-4321	2	180	sciences	sciences	PROPN
gs-4321	2	181	,	,	PUNCT
gs-4321	2	182	professor	professor	NOUN
gs-4321	2	183	,	,	PUNCT
gs-4321	2	184	director	director	NOUN
gs-4321	2	185	of	of	ADP
gs-4321	2	186	the	the	DET
gs-4321	2	187	scientific	scientific	ADJ
gs-4321	2	188	research	research	NOUN
gs-4321	2	189	-	-	PUNCT
gs-4321	2	190	skills	skill	NOUN
gs-4321	2	191	center	center	NOUN
gs-4321	2	192	at	at	ADP
gs-4321	2	193	tbilisi	tbilisi	PROPN
gs-4321	2	194	state	state	PROPN
gs-4321	2	195	medical	medical	PROPN
gs-4321	2	196	university	university	PROPN
gs-4321	2	197	,	,	PUNCT
gs-4321	2	198	professor	professor	NOUN
gs-4321	2	199	,	,	PUNCT
gs-4321	2	200	head	head	NOUN
gs-4321	2	201	of	of	ADP
gs-4321	2	202	the	the	DET
gs-4321	2	203	department	department	PROPN
gs-4321	2	204	of	of	ADP
gs-4321	2	205	medical	medical	ADJ
gs-4321	2	206	and	and	CCONJ
gs-4321	2	207	clinical	clinical	ADJ
gs-4321	2	208	pharmacology	pharmacology	NOUN
gs-4321	2	209	at	at	ADP
gs-4321	2	210	tbilisi	tbilisi	PROPN
gs-4321	2	211	state	state	PROPN
gs-4321	2	212	medical	medical	PROPN
gs-4321	2	213	university	university	PROPN
gs-4321	2	214	,	,	PUNCT
gs-4321	2	215	clinical	clinical	ADJ
gs-4321	2	216	pharmacologist	pharmacologist	NOUN
gs-4321	2	217	of	of	ADP
gs-4321	2	218	the	the	DET
gs-4321	2	219	first	first	ADJ
gs-4321	2	220	university	university	NOUN
gs-4321	2	221	clinic	clinic	NOUN
gs-4321	2	222	of	of	ADP
gs-4321	2	223	tsmu	tsmu	PROPN
gs-4321	2	224	,	,	PUNCT
gs-4321	2	225	tbilisi	tbilisi	PROPN
gs-4321	2	226	,	,	PUNCT
gs-4321	2	227	georgia	georgia	PROPN
gs-4321	2	228	;	;	PUNCT
gs-4321	2	229	https://orcid.org/0000-0003-0856-2684	https://orcid.org/0000-0003-0856-2684	NUM
gs-4321	2	230	;	;	PUNCT
gs-4321	2	231	5md	5md	ADJ
gs-4321	2	232	,	,	PUNCT
gs-4321	2	233	phd	phd	NOUN
gs-4321	2	234	,	,	PUNCT
gs-4321	2	235	doctor	doctor	NOUN
gs-4321	2	236	of	of	ADP
gs-4321	2	237	pharmaceutical	pharmaceutical	NOUN
gs-4321	2	238	sciences	science	NOUN
gs-4321	2	239	,	,	PUNCT
gs-4321	2	240	academician	academician	NOUN
gs-4321	2	241	,	,	PUNCT
gs-4321	2	242	professor	professor	NOUN
gs-4321	2	243	of	of	ADP
gs-4321	2	244	tbilisi	tbilisi	PROPN
gs-4321	2	245	state	state	PROPN
gs-4321	2	246	medical	medical	PROPN
gs-4321	2	247	university	university	PROPN
gs-4321	2	248	,	,	PUNCT
gs-4321	2	249	head	head	NOUN
gs-4321	2	250	of	of	ADP
gs-4321	2	251	the	the	DET
gs-4321	2	252	department	department	NOUN
gs-4321	2	253	of	of	ADP
gs-4321	2	254	social	social	ADJ
gs-4321	2	255	and	and	CCONJ
gs-4321	2	256	clinical	clinical	ADJ
gs-4321	2	257	pharmacy	pharmacy	NOUN
gs-4321	2	258	,	,	PUNCT
gs-4321	2	259	tbilisi	tbilisi	PROPN
gs-4321	2	260	,	,	PUNCT
gs-4321	2	261	georgia	georgia	PROPN
gs-4321	2	262	;	;	PUNCT
gs-4321	2	263	https://orcid.org/0000-0002-4563-5224	https://orcid.org/0000-0002-4563-5224	NOUN
gs-4321	2	264	;	;	PUNCT
gs-4321	2	265	6md	6md	ADJ
gs-4321	2	266	,	,	PUNCT
gs-4321	2	267	phd	phd	NOUN
gs-4321	2	268	,	,	PUNCT
gs-4321	2	269	doctor	doctor	NOUN
gs-4321	2	270	of	of	ADP
gs-4321	2	271	medical	medical	ADJ
gs-4321	2	272	sciences	science	NOUN
gs-4321	2	273	,	,	PUNCT
gs-4321	2	274	professor	professor	NOUN
gs-4321	2	275	of	of	ADP
gs-4321	2	276	faculty	faculty	NOUN
gs-4321	2	277	of	of	ADP
gs-4321	2	278	medicine	medicine	NOUN
gs-4321	2	279	at	at	ADP
gs-4321	2	280	european	european	PROPN
gs-4321	2	281	university	university	PROPN
gs-4321	2	282	,	,	PUNCT
gs-4321	2	283	professor	professor	NOUN
gs-4321	2	284	of	of	ADP
gs-4321	2	285	faculty	faculty	NOUN
gs-4321	2	286	of	of	ADP
gs-4321	2	287	medicine	medicine	NOUN
gs-4321	2	288	at	at	ADP
gs-4321	2	289	georgian	georgian	PROPN
gs-4321	2	290	national	national	PROPN
gs-4321	2	291	university	university	PROPN
gs-4321	2	292	seu	seu	NOUN
gs-4321	2	293	,	,	PUNCT
gs-4321	2	294	invited	invite	VERB
gs-4321	2	295	lecturer	lecturer	NOUN
gs-4321	2	296	of	of	ADP
gs-4321	2	297	tbilisi	tbilisi	PROPN
gs-4321	2	298	state	state	PROPN
gs-4321	2	299	medical	medical	PROPN
gs-4321	2	300	university	university	PROPN
gs-4321	2	301	,	,	PUNCT
gs-4321	2	302	tbilisi	tbilisi	PROPN
gs-4321	2	303	,	,	PUNCT
gs-4321	2	304	georgia	georgia	PROPN
gs-4321	2	305	;	;	PUNCT
gs-4321	2	306	https://orcid.org/0009-0004-2657-8473	https://orcid.org/0009-0004-2657-8473	PROPN
gs-4321	2	307	;	;	PUNCT
gs-4321	2	308	7md	7md	ADJ
gs-4321	2	309	student	student	NOUN
gs-4321	2	310	of	of	ADP
gs-4321	2	311	medical	medical	ADJ
gs-4321	2	312	doctor	doctor	NOUN
gs-4321	2	313	degree	degree	NOUN
gs-4321	2	314	program	program	NOUN
gs-4321	2	315	of	of	ADP
gs-4321	2	316	faculty	faculty	NOUN
gs-4321	2	317	of	of	ADP
gs-4321	2	318	medicine	medicine	NOUN
gs-4321	2	319	at	at	ADP
gs-4321	2	320	georgian	georgian	PROPN
gs-4321	2	321	national	national	PROPN
gs-4321	2	322	university	university	PROPN
gs-4321	2	323	seu	seu	PROPN
gs-4321	2	324	;	;	PUNCT
gs-4321	2	325	tbilisi	tbilisi	PROPN
gs-4321	2	326	,	,	PUNCT
gs-4321	2	327	georgia	georgia	PROPN
gs-4321	2	328	;	;	PUNCT
gs-4321	2	329	8md	8md	ADJ
gs-4321	2	330	,	,	PUNCT
gs-4321	2	331	phd	phd	NOUN
gs-4321	2	332	,	,	PUNCT
gs-4321	2	333	doctor	doctor	NOUN
gs-4321	2	334	of	of	ADP
gs-4321	2	335	medical	medical	ADJ
gs-4321	2	336	sciences	science	NOUN
gs-4321	2	337	,	,	PUNCT
gs-4321	2	338	professor	professor	NOUN
gs-4321	2	339	of	of	ADP
gs-4321	2	340	tbilisi	tbilisi	PROPN
gs-4321	2	341	state	state	PROPN
gs-4321	2	342	medical	medical	PROPN
gs-4321	2	343	university	university	PROPN
gs-4321	2	344	,	,	PUNCT
gs-4321	2	345	department	department	NOUN
gs-4321	2	346	of	of	ADP
gs-4321	2	347	public	public	ADJ
gs-4321	2	348	health	health	NOUN
gs-4321	2	349	,	,	PUNCT
gs-4321	2	350	health	health	NOUN
gs-4321	2	351	care	care	NOUN
gs-4321	2	352	management	management	NOUN
gs-4321	2	353	,	,	PUNCT
gs-4321	2	354	policy	policy	NOUN
gs-4321	2	355	and	and	CCONJ
gs-4321	2	356	economy	economy	NOUN
gs-4321	2	357	,	,	PUNCT
gs-4321	2	358	tbilisi	tbilisi	PROPN
gs-4321	2	359	,	,	PUNCT
gs-4321	2	360	georgia	georgia	PROPN
gs-4321	2	361	;	;	PUNCT
gs-4321	2	362	9md	9md	NOUN
gs-4321	2	363	,	,	PUNCT
gs-4321	2	364	phd	phd	NOUN
gs-4321	2	365	,	,	PUNCT
gs-4321	2	366	doctor	doctor	NOUN
gs-4321	2	367	of	of	ADP
gs-4321	2	368	medical	medical	ADJ
gs-4321	2	369	sciences	science	NOUN
gs-4321	2	370	,	,	PUNCT
gs-4321	2	371	academician	academician	NOUN
gs-4321	2	372	,	,	PUNCT
gs-4321	2	373	professor	professor	NOUN
gs-4321	2	374	of	of	ADP
gs-4321	2	375	tbilisi	tbilisi	PROPN
gs-4321	2	376	state	state	PROPN
gs-4321	2	377	medical	medical	PROPN
gs-4321	2	378	university	university	PROPN
gs-4321	2	379	,	,	PUNCT
gs-4321	2	380	dean	dean	NOUN
gs-4321	2	381	of	of	ADP
gs-4321	2	382	the	the	DET
gs-4321	2	383	faculty	faculty	NOUN
gs-4321	2	384	of	of	ADP
gs-4321	2	385	public	public	ADJ
gs-4321	2	386	health	health	NOUN
gs-4321	2	387	,	,	PUNCT
gs-4321	2	388	head	head	NOUN
gs-4321	2	389	of	of	ADP
gs-4321	2	390	the	the	DET
gs-4321	2	391	department	department	NOUN
gs-4321	2	392	of	of	ADP
gs-4321	2	393	nutrition	nutrition	NOUN
gs-4321	2	394	,	,	PUNCT
gs-4321	2	395	aging	age	VERB
gs-4321	2	396	medicine	medicine	NOUN
gs-4321	2	397	,	,	PUNCT
gs-4321	2	398	environmental	environmental	ADJ
gs-4321	2	399	and	and	CCONJ
gs-4321	2	400	occupational	occupational	ADJ
gs-4321	2	401	health	health	NOUN
gs-4321	2	402	,	,	PUNCT
gs-4321	2	403	tbilisi	tbilisi	PROPN
gs-4321	2	404	,	,	PUNCT
gs-4321	2	405	georgia	georgia	PROPN
gs-4321	2	406	;	;	PUNCT
gs-4321	2	407	10phd	10phd	NUM
gs-4321	2	408	,	,	PUNCT
gs-4321	2	409	invited	invite	VERB
gs-4321	2	410	lecturer	lecturer	NOUN
gs-4321	2	411	(	(	PUNCT
gs-4321	2	412	professor	professor	NOUN
gs-4321	2	413	)	)	PUNCT
gs-4321	2	414	of	of	ADP
gs-4321	2	415	biochemistry	biochemistry	NOUN
gs-4321	2	416	,	,	PUNCT
gs-4321	2	417	university	university	PROPN
gs-4321	2	418	of	of	ADP
gs-4321	2	419	georgia	georgia	PROPN
gs-4321	2	420	,	,	PUNCT
gs-4321	2	421	tbilisi	tbilisi	PROPN
gs-4321	2	422	georgia	georgia	PROPN
gs-4321	2	423	;	;	PUNCT
gs-4321	2	424	orcid	orcid	PROPN
gs-4321	2	425	:	:	PUNCT
gs-4321	2	426	https://orcid.org/0000-0001-62166477	https://orcid.org/0000-0001-62166477	NOUN
gs-4321	2	427	corresponding	correspond	VERB
gs-4321	2	428	author	author	NOUN
gs-4321	2	429	:	:	PUNCT
gs-4321	2	430	dr	dr	PROPN
gs-4321	2	431	.	.	PROPN
gs-4321	2	432	professor	professor	PROPN
gs-4321	2	433	nodar	nodar	PROPN
gs-4321	2	434	sulashvili	sulashvili	PROPN
gs-4321	2	435	mail	mail	NOUN
gs-4321	2	436	:	:	PUNCT
gs-4321	2	437	n.sulashvili@ug.edu.ge	n.sulashvili@ug.edu.ge	NOUN
gs-4321	2	438	mob	mob	NOUN
gs-4321	2	439	:	:	PUNCT
gs-4321	2	440	+995	+995	ADJ
gs-4321	2	441	-	-	ADJ
gs-4321	2	442	597	597	NUM
gs-4321	2	443	-	-	PUNCT
gs-4321	2	444	12	12	NUM
gs-4321	2	445	-	-	PUNCT
gs-4321	2	446	17	17	NUM
gs-4321	2	447	-	-	SYM
gs-4321	2	448	28	28	NUM
gs-4321	2	449	abstract	abstract	ADJ
gs-4321	2	450	cancer	cancer	NOUN
gs-4321	2	451	stem	stem	NOUN
gs-4321	2	452	cell	cell	NOUN
gs-4321	2	453	(	(	PUNCT
gs-4321	2	454	csc	csc	PROPN
gs-4321	2	455	)	)	PUNCT
gs-4321	2	456	plasticity	plasticity	NOUN
gs-4321	2	457	is	be	AUX
gs-4321	2	458	increasingly	increasingly	ADV
gs-4321	2	459	recognized	recognize	VERB
gs-4321	2	460	as	as	ADP
gs-4321	2	461	a	a	DET
gs-4321	2	462	central	central	ADJ
gs-4321	2	463	driver	driver	NOUN
gs-4321	2	464	of	of	ADP
gs-4321	2	465	tumor	tumor	NOUN
gs-4321	2	466	initiation	initiation	NOUN
gs-4321	2	467	,	,	PUNCT
gs-4321	2	468	therapeutic	therapeutic	ADJ
gs-4321	2	469	resistance	resistance	NOUN
gs-4321	2	470	,	,	PUNCT
gs-4321	2	471	metastatic	metastatic	ADJ
gs-4321	2	472	dissemination	dissemination	NOUN
gs-4321	2	473	,	,	PUNCT
gs-4321	2	474	and	and	CCONJ
gs-4321	2	475	disease	disease	NOUN
gs-4321	2	476	recurrence	recurrence	NOUN
gs-4321	2	477	.	.	PUNCT
gs-4321	3	1	yet	yet	ADV
gs-4321	3	2	,	,	PUNCT
gs-4321	3	3	the	the	DET
gs-4321	3	4	georgian	georgian	NOUN
gs-4321	3	5	scientists/	scientists/	NUM
gs-4321	3	6	.	.	PUNCT
gs-4321	4	1	7	7	NUM
gs-4321	4	2	n	n	DET
gs-4321	4	3	4	4	NUM
gs-4321	4	4	,	,	PUNCT
gs-4321	4	5	2025	2025	NUM
gs-4321	4	6	334	334	NUM
gs-4321	4	7	dynamic	dynamic	ADJ
gs-4321	4	8	transitions	transition	NOUN
gs-4321	4	9	between	between	ADP
gs-4321	4	10	stem	stem	NOUN
gs-4321	4	11	-	-	PUNCT
gs-4321	4	12	like	like	ADJ
gs-4321	4	13	and	and	CCONJ
gs-4321	4	14	differentiated	differentiated	ADJ
gs-4321	4	15	malignant	malignant	ADJ
gs-4321	4	16	states	state	NOUN
gs-4321	4	17	remain	remain	AUX
gs-4321	4	18	poorly	poorly	ADV
gs-4321	4	19	resolved	resolve	VERB
gs-4321	4	20	due	due	ADP
gs-4321	4	21	to	to	ADP
gs-4321	4	22	the	the	DET
gs-4321	4	23	intrinsic	intrinsic	ADJ
gs-4321	4	24	heterogeneity	heterogeneity	NOUN
gs-4321	4	25	of	of	ADP
gs-4321	4	26	tumors	tumor	NOUN
gs-4321	4	27	and	and	CCONJ
gs-4321	4	28	the	the	DET
gs-4321	4	29	limitations	limitation	NOUN
gs-4321	4	30	of	of	ADP
gs-4321	4	31	bulk	bulk	ADJ
gs-4321	4	32	profiling	profiling	NOUN
gs-4321	4	33	methods	method	NOUN
gs-4321	4	34	.	.	PUNCT
gs-4321	5	1	recent	recent	ADJ
gs-4321	5	2	advances	advance	NOUN
gs-4321	5	3	in	in	ADP
gs-4321	5	4	single	single	ADJ
gs-4321	5	5	-	-	PUNCT
gs-4321	5	6	cell	cell	NOUN
gs-4321	5	7	sequencing	sequence	VERB
gs-4321	5	8	technologies	technology	NOUN
gs-4321	5	9	have	have	AUX
gs-4321	5	10	created	create	VERB
gs-4321	5	11	an	an	DET
gs-4321	5	12	unprecedented	unprecedented	ADJ
gs-4321	5	13	opportunity	opportunity	NOUN
gs-4321	5	14	to	to	PART
gs-4321	5	15	dissect	dissect	VERB
gs-4321	5	16	csc	csc	PROPN
gs-4321	5	17	states	state	NOUN
gs-4321	5	18	at	at	ADP
gs-4321	5	19	high	high	ADJ
gs-4321	5	20	resolution	resolution	NOUN
gs-4321	5	21	;	;	PUNCT
gs-4321	5	22	however	however	ADV
gs-4321	5	23	,	,	PUNCT
gs-4321	5	24	extracting	extract	VERB
gs-4321	5	25	mechanistic	mechanistic	ADJ
gs-4321	5	26	insights	insight	NOUN
gs-4321	5	27	from	from	ADP
gs-4321	5	28	these	these	DET
gs-4321	5	29	data	datum	NOUN
gs-4321	5	30	requires	require	VERB
gs-4321	5	31	sophisticated	sophisticated	ADJ
gs-4321	5	32	computational	computational	ADJ
gs-4321	5	33	methods	method	NOUN
gs-4321	5	34	.	.	PUNCT
gs-4321	6	1	in	in	ADP
gs-4321	6	2	this	this	DET
gs-4321	6	3	work	work	NOUN
gs-4321	6	4	,	,	PUNCT
gs-4321	6	5	we	we	PRON
gs-4321	6	6	present	present	VERB
gs-4321	6	7	an	an	DET
gs-4321	6	8	integrative	integrative	ADJ
gs-4321	6	9	bioinformatic	bioinformatic	ADJ
gs-4321	6	10	framework	framework	NOUN
gs-4321	6	11	for	for	ADP
gs-4321	6	12	characterizing	characterize	VERB
gs-4321	6	13	csc	csc	PROPN
gs-4321	6	14	plasticity	plasticity	NOUN
gs-4321	6	15	across	across	ADP
gs-4321	6	16	diverse	diverse	ADJ
gs-4321	6	17	cancer	cancer	NOUN
gs-4321	6	18	types	type	NOUN
gs-4321	6	19	using	use	VERB
gs-4321	6	20	single	single	ADJ
gs-4321	6	21	-	-	PUNCT
gs-4321	6	22	cell	cell	NOUN
gs-4321	6	23	transcriptomic	transcriptomic	NOUN
gs-4321	6	24	,	,	PUNCT
gs-4321	6	25	epigenomic	epigenomic	ADJ
gs-4321	6	26	,	,	PUNCT
gs-4321	6	27	and	and	CCONJ
gs-4321	6	28	proteogenomic	proteogenomic	ADJ
gs-4321	6	29	datasets	dataset	NOUN
gs-4321	6	30	.	.	PUNCT
gs-4321	7	1	our	our	PRON
gs-4321	7	2	approach	approach	NOUN
gs-4321	7	3	synthesizes	synthesize	VERB
gs-4321	7	4	multiple	multiple	ADJ
gs-4321	7	5	layers	layer	NOUN
gs-4321	7	6	of	of	ADP
gs-4321	7	7	information	information	NOUN
gs-4321	7	8	—	—	PUNCT
gs-4321	7	9	including	include	VERB
gs-4321	7	10	transcriptional	transcriptional	ADJ
gs-4321	7	11	variability	variability	NOUN
gs-4321	7	12	,	,	PUNCT
gs-4321	7	13	regulatory	regulatory	ADJ
gs-4321	7	14	network	network	NOUN
gs-4321	7	15	inference	inference	NOUN
gs-4321	7	16	,	,	PUNCT
gs-4321	7	17	cell	cell	NOUN
gs-4321	7	18	trajectory	trajectory	NOUN
gs-4321	7	19	reconstruction	reconstruction	NOUN
gs-4321	7	20	,	,	PUNCT
gs-4321	7	21	chromatin	chromatin	NOUN
gs-4321	7	22	accessibility	accessibility	NOUN
gs-4321	7	23	,	,	PUNCT
gs-4321	7	24	ligand	ligand	NOUN
gs-4321	7	25	–	–	PUNCT
gs-4321	7	26	receptor	receptor	NOUN
gs-4321	7	27	communication	communication	NOUN
gs-4321	7	28	,	,	PUNCT
gs-4321	7	29	and	and	CCONJ
gs-4321	7	30	lineage	lineage	NOUN
gs-4321	7	31	mapping	mapping	NOUN
gs-4321	7	32	—	—	PUNCT
gs-4321	7	33	to	to	PART
gs-4321	7	34	identify	identify	VERB
gs-4321	7	35	key	key	ADJ
gs-4321	7	36	determinants	determinant	NOUN
gs-4321	7	37	that	that	PRON
gs-4321	7	38	regulate	regulate	VERB
gs-4321	7	39	transitions	transition	NOUN
gs-4321	7	40	between	between	ADP
gs-4321	7	41	stem	stem	NOUN
gs-4321	7	42	-	-	PUNCT
gs-4321	7	43	like	like	ADJ
gs-4321	7	44	,	,	PUNCT
gs-4321	7	45	progenitor	progenitor	NOUN
gs-4321	7	46	-	-	PUNCT
gs-4321	7	47	like	like	ADJ
gs-4321	7	48	,	,	PUNCT
gs-4321	7	49	and	and	CCONJ
gs-4321	7	50	differentiated	differentiated	ADJ
gs-4321	7	51	malignant	malignant	ADJ
gs-4321	7	52	phenotypes	phenotype	NOUN
gs-4321	7	53	.	.	PUNCT
gs-4321	8	1	through	through	ADP
gs-4321	8	2	integrative	integrative	ADJ
gs-4321	8	3	clustering	clustering	NOUN
gs-4321	8	4	,	,	PUNCT
gs-4321	8	5	pseudotime	pseudotime	ADJ
gs-4321	8	6	analysis	analysis	NOUN
gs-4321	8	7	,	,	PUNCT
gs-4321	8	8	and	and	CCONJ
gs-4321	8	9	machine	machine	NOUN
gs-4321	8	10	-	-	PUNCT
gs-4321	8	11	learning	learning	NOUN
gs-4321	8	12	–	–	PUNCT
gs-4321	8	13	based	base	VERB
gs-4321	8	14	state	state	NOUN
gs-4321	8	15	prediction	prediction	NOUN
gs-4321	8	16	,	,	PUNCT
gs-4321	8	17	we	we	PRON
gs-4321	8	18	uncover	uncover	VERB
gs-4321	8	19	conserved	conserve	VERB
gs-4321	8	20	molecular	molecular	ADJ
gs-4321	8	21	programs	program	NOUN
gs-4321	8	22	and	and	CCONJ
gs-4321	8	23	dynamic	dynamic	ADJ
gs-4321	8	24	regulatory	regulatory	ADJ
gs-4321	8	25	modules	module	NOUN
gs-4321	8	26	that	that	PRON
gs-4321	8	27	define	define	VERB
gs-4321	8	28	csc	csc	PROPN
gs-4321	8	29	behavior	behavior	NOUN
gs-4321	8	30	.	.	PUNCT
gs-4321	9	1	furthermore	furthermore	ADV
gs-4321	9	2	,	,	PUNCT
gs-4321	9	3	we	we	PRON
gs-4321	9	4	implement	implement	VERB
gs-4321	9	5	cell	cell	NOUN
gs-4321	9	6	–	–	PUNCT
gs-4321	9	7	cell	cell	NOUN
gs-4321	9	8	communication	communication	NOUN
gs-4321	9	9	modeling	modeling	NOUN
gs-4321	9	10	to	to	PART
gs-4321	9	11	map	map	VERB
gs-4321	9	12	how	how	SCONJ
gs-4321	9	13	csc	csc	ADJ
gs-4321	9	14	niche	niche	NOUN
gs-4321	9	15	interactions	interaction	NOUN
gs-4321	9	16	influence	influence	NOUN
gs-4321	9	17	plasticity	plasticity	NOUN
gs-4321	9	18	,	,	PUNCT
gs-4321	9	19	focusing	focus	VERB
gs-4321	9	20	on	on	ADP
gs-4321	9	21	immune	immune	ADJ
gs-4321	9	22	–	–	PUNCT
gs-4321	9	23	csc	csc	PROPN
gs-4321	9	24	crosstalk	crosstalk	NOUN
gs-4321	9	25	,	,	PUNCT
gs-4321	9	26	stromal	stromal	ADJ
gs-4321	9	27	signaling	signal	VERB
gs-4321	9	28	circuits	circuit	NOUN
gs-4321	9	29	,	,	PUNCT
gs-4321	9	30	and	and	CCONJ
gs-4321	9	31	exosome	exosome	ADV
gs-4321	9	32	-	-	PUNCT
gs-4321	9	33	mediated	mediate	VERB
gs-4321	9	34	molecular	molecular	ADJ
gs-4321	9	35	transport	transport	NOUN
gs-4321	9	36	.	.	PUNCT
gs-4321	10	1	the	the	DET
gs-4321	10	2	combined	combine	VERB
gs-4321	10	3	analysis	analysis	NOUN
gs-4321	10	4	highlights	highlight	NOUN
gs-4321	10	5	novel	novel	ADJ
gs-4321	10	6	candidate	candidate	NOUN
gs-4321	10	7	biomarkers	biomarker	NOUN
gs-4321	10	8	and	and	CCONJ
gs-4321	10	9	therapeutic	therapeutic	ADJ
gs-4321	10	10	vulnerabilities	vulnerability	NOUN
gs-4321	10	11	associated	associate	VERB
gs-4321	10	12	with	with	ADP
gs-4321	10	13	reversible	reversible	ADJ
gs-4321	10	14	stemness	stemness	NOUN
gs-4321	10	15	states	state	NOUN
gs-4321	10	16	.	.	PUNCT
gs-4321	11	1	together	together	ADV
gs-4321	11	2	,	,	PUNCT
gs-4321	11	3	this	this	DET
gs-4321	11	4	study	study	NOUN
gs-4321	11	5	demonstrates	demonstrate	VERB
gs-4321	11	6	that	that	SCONJ
gs-4321	11	7	integrated	integrate	VERB
gs-4321	11	8	single	single	ADJ
gs-4321	11	9	-	-	PUNCT
gs-4321	11	10	cell	cell	NOUN
gs-4321	11	11	bioinformatic	bioinformatic	ADJ
gs-4321	11	12	analysis	analysis	NOUN
gs-4321	11	13	provides	provide	VERB
gs-4321	11	14	a	a	DET
gs-4321	11	15	powerful	powerful	ADJ
gs-4321	11	16	framework	framework	NOUN
gs-4321	11	17	to	to	PART
gs-4321	11	18	decode	decode	VERB
gs-4321	11	19	cancer	cancer	NOUN
gs-4321	11	20	stem	stem	NOUN
gs-4321	11	21	cell	cell	NOUN
gs-4321	11	22	plasticity	plasticity	NOUN
gs-4321	11	23	,	,	PUNCT
gs-4321	11	24	enabling	enable	VERB
gs-4321	11	25	a	a	DET
gs-4321	11	26	deeper	deeply	ADV
gs-4321	11	27	mechanistic	mechanistic	ADJ
gs-4321	11	28	understanding	understanding	NOUN
gs-4321	11	29	of	of	ADP
gs-4321	11	30	tumor	tumor	NOUN
gs-4321	11	31	evolution	evolution	NOUN
gs-4321	11	32	and	and	CCONJ
gs-4321	11	33	identifying	identify	VERB
gs-4321	11	34	new	new	ADJ
gs-4321	11	35	avenues	avenue	NOUN
gs-4321	11	36	for	for	ADP
gs-4321	11	37	precision	precision	NOUN
gs-4321	11	38	oncology	oncology	NOUN
gs-4321	11	39	and	and	CCONJ
gs-4321	11	40	targeted	target	VERB
gs-4321	11	41	therapeutic	therapeutic	ADJ
gs-4321	11	42	interventions	intervention	NOUN
gs-4321	11	43	.	.	PUNCT
gs-4321	12	1	keywords	keyword	NOUN
gs-4321	12	2	:	:	PUNCT
gs-4321	12	3	cancer	cancer	NOUN
gs-4321	12	4	stem	stem	NOUN
gs-4321	12	5	cell	cell	NOUN
gs-4321	12	6	plasticity	plasticity	NOUN
gs-4321	12	7	,	,	PUNCT
gs-4321	12	8	tumor	tumor	NOUN
gs-4321	12	9	microenvironment	microenvironment	NOUN
gs-4321	12	10	,	,	PUNCT
gs-4321	12	11	single	single	ADJ
gs-4321	12	12	-	-	PUNCT
gs-4321	12	13	cell	cell	NOUN
gs-4321	12	14	multi	multi	NOUN
gs-4321	12	15	-	-	NOUN
gs-4321	12	16	omics	omic	NOUN
gs-4321	12	17	,	,	PUNCT
gs-4321	12	18	phenotypic	phenotypic	ADJ
gs-4321	12	19	heterogeneity	heterogeneity	NOUN
gs-4321	12	20	,	,	PUNCT
gs-4321	12	21	therapeutic	therapeutic	ADJ
gs-4321	12	22	resistance	resistance	NOUN
gs-4321	12	23	,	,	PUNCT
gs-4321	12	24	bioinformatics	bioinformatics	NOUN
gs-4321	12	25	integration	integration	NOUN
gs-4321	12	26	,	,	PUNCT
gs-4321	12	27	cell	cell	NOUN
gs-4321	12	28	-	-	PUNCT
gs-4321	12	29	cell	cell	NOUN
gs-4321	12	30	communication	communication	NOUN
gs-4321	12	31	.	.	PUNCT
gs-4321	13	1	introduction	introduction	NOUN
gs-4321	13	2	the	the	DET
gs-4321	13	3	concept	concept	NOUN
gs-4321	13	4	of	of	ADP
gs-4321	13	5	cellular	cellular	ADJ
gs-4321	13	6	heterogeneity	heterogeneity	NOUN
gs-4321	13	7	within	within	ADP
gs-4321	13	8	tumors	tumor	NOUN
gs-4321	13	9	has	have	AUX
gs-4321	13	10	fundamentally	fundamentally	ADV
gs-4321	13	11	reshaped	reshape	VERB
gs-4321	13	12	modern	modern	ADJ
gs-4321	13	13	oncology	oncology	NOUN
gs-4321	13	14	,	,	PUNCT
gs-4321	13	15	revealing	reveal	VERB
gs-4321	13	16	that	that	SCONJ
gs-4321	13	17	malignant	malignant	ADJ
gs-4321	13	18	tissues	tissue	NOUN
gs-4321	13	19	are	be	AUX
gs-4321	13	20	not	not	PART
gs-4321	13	21	uniform	uniform	ADJ
gs-4321	13	22	masses	masse	NOUN
gs-4321	13	23	of	of	ADP
gs-4321	13	24	identical	identical	ADJ
gs-4321	13	25	cells	cell	NOUN
gs-4321	13	26	but	but	CCONJ
gs-4321	13	27	complex	complex	ADJ
gs-4321	13	28	ecosystems	ecosystem	NOUN
gs-4321	13	29	composed	compose	VERB
gs-4321	13	30	of	of	ADP
gs-4321	13	31	diverse	diverse	ADJ
gs-4321	13	32	subpopulations	subpopulation	NOUN
gs-4321	13	33	with	with	ADP
gs-4321	13	34	distinct	distinct	ADJ
gs-4321	13	35	functional	functional	ADJ
gs-4321	13	36	roles	role	NOUN
gs-4321	13	37	,	,	PUNCT
gs-4321	13	38	developmental	developmental	ADJ
gs-4321	13	39	trajectories	trajectory	NOUN
gs-4321	13	40	,	,	PUNCT
gs-4321	13	41	and	and	CCONJ
gs-4321	13	42	therapeutic	therapeutic	ADJ
gs-4321	13	43	sensitivities	sensitivity	NOUN
gs-4321	13	44	.	.	PUNCT
gs-4321	14	1	among	among	ADP
gs-4321	14	2	these	these	DET
gs-4321	14	3	subpopulations	subpopulation	NOUN
gs-4321	14	4	,	,	PUNCT
gs-4321	14	5	cells	cell	NOUN
gs-4321	14	6	displaying	display	VERB
gs-4321	14	7	stem	stem	NOUN
gs-4321	14	8	-	-	PUNCT
gs-4321	14	9	like	like	ADJ
gs-4321	14	10	features	feature	NOUN
gs-4321	14	11	have	have	AUX
gs-4321	14	12	attracted	attract	VERB
gs-4321	14	13	intense	intense	ADJ
gs-4321	14	14	attention	attention	NOUN
gs-4321	14	15	due	due	ADP
gs-4321	14	16	to	to	ADP
gs-4321	14	17	their	their	PRON
gs-4321	14	18	capacity	capacity	NOUN
gs-4321	14	19	for	for	ADP
gs-4321	14	20	selfrenewal	selfrenewal	NOUN
gs-4321	14	21	,	,	PUNCT
gs-4321	14	22	multipotency	multipotency	NOUN
gs-4321	14	23	,	,	PUNCT
gs-4321	14	24	and	and	CCONJ
gs-4321	14	25	remarkable	remarkable	ADJ
gs-4321	14	26	adaptability	adaptability	NOUN
gs-4321	14	27	.	.	PUNCT
gs-4321	15	1	these	these	DET
gs-4321	15	2	stem	stem	NOUN
gs-4321	15	3	-	-	PUNCT
gs-4321	15	4	associated	associate	VERB
gs-4321	15	5	characteristics	characteristic	NOUN
gs-4321	15	6	,	,	PUNCT
gs-4321	15	7	often	often	ADV
gs-4321	15	8	collectively	collectively	ADV
gs-4321	15	9	summarized	summarize	VERB
gs-4321	15	10	as	as	ADP
gs-4321	15	11	“	"	PUNCT
gs-4321	15	12	plasticity	plasticity	NOUN
gs-4321	15	13	,	,	PUNCT
gs-4321	15	14	”	"	PUNCT
gs-4321	15	15	enable	enable	VERB
gs-4321	15	16	cancer	cancer	NOUN
gs-4321	15	17	cells	cell	NOUN
gs-4321	15	18	to	to	PART
gs-4321	15	19	transition	transition	NOUN
gs-4321	15	20	between	between	ADP
gs-4321	15	21	different	different	ADJ
gs-4321	15	22	phenotypic	phenotypic	ADJ
gs-4321	15	23	states	state	NOUN
gs-4321	15	24	in	in	ADP
gs-4321	15	25	response	response	NOUN
gs-4321	15	26	to	to	ADP
gs-4321	15	27	environmental	environmental	ADJ
gs-4321	15	28	pressures	pressure	NOUN
gs-4321	15	29	,	,	PUNCT
gs-4321	15	30	therapy	therapy	NOUN
gs-4321	15	31	-	-	PUNCT
gs-4321	15	32	induced	induce	VERB
gs-4321	15	33	stress	stress	NOUN
gs-4321	15	34	,	,	PUNCT
gs-4321	15	35	and	and	CCONJ
gs-4321	15	36	intrinsic	intrinsic	ADJ
gs-4321	15	37	molecular	molecular	ADJ
gs-4321	15	38	cues	cue	NOUN
gs-4321	15	39	.	.	PUNCT
gs-4321	16	1	studies	study	NOUN
gs-4321	16	2	across	across	ADP
gs-4321	16	3	malignancies	malignancy	NOUN
gs-4321	16	4	—	—	PUNCT
gs-4321	16	5	including	include	VERB
gs-4321	16	6	glioblastoma	glioblastoma	NOUN
gs-4321	16	7	,	,	PUNCT
gs-4321	16	8	breast	breast	NOUN
gs-4321	16	9	georgian	georgian	NOUN
gs-4321	16	10	scientists/	scientists/	NUM
gs-4321	16	11	.	.	PUNCT
gs-4321	17	1	7	7	NUM
gs-4321	17	2	n	n	DET
gs-4321	17	3	4	4	NUM
gs-4321	17	4	,	,	PUNCT
gs-4321	17	5	2025	2025	NUM
gs-4321	17	6	335	335	NUM
gs-4321	17	7	cancer	cancer	NOUN
gs-4321	17	8	,	,	PUNCT
gs-4321	17	9	colorectal	colorectal	ADJ
gs-4321	17	10	carcinoma	carcinoma	NOUN
gs-4321	17	11	,	,	PUNCT
gs-4321	17	12	and	and	CCONJ
gs-4321	17	13	melanoma	melanoma	NOUN
gs-4321	17	14	—	—	PUNCT
gs-4321	17	15	consistently	consistently	ADV
gs-4321	17	16	demonstrate	demonstrate	VERB
gs-4321	17	17	that	that	SCONJ
gs-4321	17	18	stem	stem	NOUN
gs-4321	17	19	-	-	PUNCT
gs-4321	17	20	like	like	ADJ
gs-4321	17	21	malignant	malignant	ADJ
gs-4321	17	22	cells	cell	NOUN
gs-4321	17	23	contribute	contribute	VERB
gs-4321	17	24	disproportionately	disproportionately	ADV
gs-4321	17	25	to	to	ADP
gs-4321	17	26	drug	drug	NOUN
gs-4321	17	27	resistance	resistance	NOUN
gs-4321	17	28	,	,	PUNCT
gs-4321	17	29	metastatic	metastatic	ADJ
gs-4321	17	30	competence	competence	NOUN
gs-4321	17	31	,	,	PUNCT
gs-4321	17	32	tumor	tumor	NOUN
gs-4321	17	33	relapse	relapse	NOUN
gs-4321	17	34	,	,	PUNCT
gs-4321	17	35	and	and	CCONJ
gs-4321	17	36	poor	poor	ADJ
gs-4321	17	37	clinical	clinical	ADJ
gs-4321	17	38	outcomes	outcome	NOUN
gs-4321	17	39	(	(	PUNCT
gs-4321	17	40	batlle	batlle	NOUN
gs-4321	17	41	and	and	CCONJ
gs-4321	17	42	clevers	clever	NOUN
gs-4321	17	43	,	,	PUNCT
gs-4321	17	44	2017	2017	NUM
gs-4321	17	45	;	;	PUNCT
gs-4321	17	46	meacham	meacham	PROPN
gs-4321	17	47	and	and	CCONJ
gs-4321	17	48	morrison	morrison	PROPN
gs-4321	17	49	,	,	PUNCT
gs-4321	17	50	2013	2013	NUM
gs-4321	17	51	)	)	PUNCT
gs-4321	17	52	.	.	PUNCT
gs-4321	18	1	despite	despite	SCONJ
gs-4321	18	2	this	this	PRON
gs-4321	18	3	,	,	PUNCT
gs-4321	18	4	the	the	DET
gs-4321	18	5	mechanisms	mechanism	NOUN
gs-4321	18	6	that	that	PRON
gs-4321	18	7	govern	govern	VERB
gs-4321	18	8	the	the	DET
gs-4321	18	9	emergence	emergence	NOUN
gs-4321	18	10	,	,	PUNCT
gs-4321	18	11	maintenance	maintenance	NOUN
gs-4321	18	12	,	,	PUNCT
gs-4321	18	13	and	and	CCONJ
gs-4321	18	14	evolution	evolution	NOUN
gs-4321	18	15	of	of	ADP
gs-4321	18	16	these	these	DET
gs-4321	18	17	states	state	NOUN
gs-4321	18	18	remain	remain	AUX
gs-4321	18	19	incompletely	incompletely	ADV
gs-4321	18	20	defined	define	VERB
gs-4321	18	21	.	.	PUNCT
gs-4321	19	1	the	the	DET
gs-4321	19	2	growing	grow	VERB
gs-4321	19	3	recognition	recognition	NOUN
gs-4321	19	4	that	that	SCONJ
gs-4321	19	5	malignant	malignant	ADJ
gs-4321	19	6	tissues	tissue	NOUN
gs-4321	19	7	behave	behave	VERB
gs-4321	19	8	as	as	ADP
gs-4321	19	9	dynamic	dynamic	ADJ
gs-4321	19	10	,	,	PUNCT
gs-4321	19	11	adaptive	adaptive	ADJ
gs-4321	19	12	systems	system	NOUN
gs-4321	19	13	has	have	AUX
gs-4321	19	14	created	create	VERB
gs-4321	19	15	an	an	DET
gs-4321	19	16	urgent	urgent	ADJ
gs-4321	19	17	need	need	NOUN
gs-4321	19	18	for	for	ADP
gs-4321	19	19	analytical	analytical	ADJ
gs-4321	19	20	frameworks	framework	NOUN
gs-4321	19	21	capable	capable	ADJ
gs-4321	19	22	of	of	ADP
gs-4321	19	23	disentangling	disentangle	VERB
gs-4321	19	24	the	the	DET
gs-4321	19	25	molecular	molecular	ADJ
gs-4321	19	26	architecture	architecture	NOUN
gs-4321	19	27	underlying	underlie	VERB
gs-4321	19	28	state	state	NOUN
gs-4321	19	29	transitions	transition	NOUN
gs-4321	19	30	.	.	PUNCT
gs-4321	20	1	traditional	traditional	ADJ
gs-4321	20	2	bulk	bulk	ADJ
gs-4321	20	3	sequencing	sequence	VERB
gs-4321	20	4	approaches	approach	NOUN
gs-4321	20	5	,	,	PUNCT
gs-4321	20	6	while	while	SCONJ
gs-4321	20	7	deeply	deeply	ADV
gs-4321	20	8	informative	informative	ADJ
gs-4321	20	9	,	,	PUNCT
gs-4321	20	10	average	average	ADJ
gs-4321	20	11	signals	signal	NOUN
gs-4321	20	12	across	across	ADP
gs-4321	20	13	thousands	thousand	NOUN
gs-4321	20	14	or	or	CCONJ
gs-4321	20	15	millions	million	NOUN
gs-4321	20	16	of	of	ADP
gs-4321	20	17	cells	cell	NOUN
gs-4321	20	18	,	,	PUNCT
gs-4321	20	19	obscuring	obscure	VERB
gs-4321	20	20	the	the	DET
gs-4321	20	21	subtle	subtle	ADJ
gs-4321	20	22	transcriptional	transcriptional	ADJ
gs-4321	20	23	,	,	PUNCT
gs-4321	20	24	epigenetic	epigenetic	ADJ
gs-4321	20	25	,	,	PUNCT
gs-4321	20	26	and	and	CCONJ
gs-4321	20	27	proteogenomic	proteogenomic	ADJ
gs-4321	20	28	programs	program	NOUN
gs-4321	20	29	that	that	PRON
gs-4321	20	30	define	define	VERB
gs-4321	20	31	rare	rare	ADJ
gs-4321	20	32	but	but	CCONJ
gs-4321	20	33	clinically	clinically	ADV
gs-4321	20	34	significant	significant	ADJ
gs-4321	20	35	subpopulations	subpopulation	NOUN
gs-4321	20	36	.	.	PUNCT
gs-4321	21	1	consequently	consequently	ADV
gs-4321	21	2	,	,	PUNCT
gs-4321	21	3	these	these	DET
gs-4321	21	4	methods	method	NOUN
gs-4321	21	5	can	can	AUX
gs-4321	21	6	not	not	PART
gs-4321	21	7	resolve	resolve	VERB
gs-4321	21	8	the	the	DET
gs-4321	21	9	true	true	ADJ
gs-4321	21	10	landscape	landscape	NOUN
gs-4321	21	11	of	of	ADP
gs-4321	21	12	lineage	lineage	NOUN
gs-4321	21	13	hierarchies	hierarchy	NOUN
gs-4321	21	14	or	or	CCONJ
gs-4321	21	15	capture	capture	VERB
gs-4321	21	16	the	the	DET
gs-4321	21	17	stochastic	stochastic	ADJ
gs-4321	21	18	and	and	CCONJ
gs-4321	21	19	reversible	reversible	ADJ
gs-4321	21	20	plasticity	plasticity	NOUN
gs-4321	21	21	that	that	PRON
gs-4321	21	22	characterizes	characterize	VERB
gs-4321	21	23	stem	stem	NOUN
gs-4321	21	24	-	-	PUNCT
gs-4321	21	25	associated	associate	VERB
gs-4321	21	26	phenotypes	phenotype	NOUN
gs-4321	21	27	.	.	PUNCT
gs-4321	22	1	the	the	DET
gs-4321	22	2	emergence	emergence	NOUN
gs-4321	22	3	of	of	ADP
gs-4321	22	4	single	single	ADJ
gs-4321	22	5	-	-	PUNCT
gs-4321	22	6	cell	cell	NOUN
gs-4321	22	7	technologies	technology	NOUN
gs-4321	22	8	—	—	PUNCT
gs-4321	22	9	including	include	VERB
gs-4321	22	10	single	single	ADJ
gs-4321	22	11	-	-	PUNCT
gs-4321	22	12	cell	cell	NOUN
gs-4321	22	13	rna	rna	NOUN
gs-4321	22	14	sequencing	sequence	VERB
gs-4321	22	15	(	(	PUNCT
gs-4321	22	16	scrna	scrna	NOUN
gs-4321	22	17	-	-	PUNCT
gs-4321	22	18	seq	seq	NOUN
gs-4321	22	19	)	)	PUNCT
gs-4321	22	20	,	,	PUNCT
gs-4321	22	21	single	single	ADJ
gs-4321	22	22	-	-	PUNCT
gs-4321	22	23	cell	cell	NOUN
gs-4321	22	24	atac	atac	NOUN
gs-4321	22	25	-	-	PUNCT
gs-4321	22	26	seq	seq	NOUN
gs-4321	22	27	,	,	PUNCT
gs-4321	22	28	and	and	CCONJ
gs-4321	22	29	multimodal	multimodal	NOUN
gs-4321	22	30	approaches	approach	NOUN
gs-4321	22	31	that	that	PRON
gs-4321	22	32	couple	couple	NOUN
gs-4321	22	33	transcriptomic	transcriptomic	ADJ
gs-4321	22	34	,	,	PUNCT
gs-4321	22	35	epigenomic	epigenomic	ADJ
gs-4321	22	36	,	,	PUNCT
gs-4321	22	37	and	and	CCONJ
gs-4321	22	38	surface	surface	NOUN
gs-4321	22	39	protein	protein	NOUN
gs-4321	22	40	information	information	NOUN
gs-4321	22	41	—	—	PUNCT
gs-4321	22	42	has	have	AUX
gs-4321	22	43	transformed	transform	VERB
gs-4321	22	44	this	this	DET
gs-4321	22	45	landscape	landscape	NOUN
gs-4321	22	46	.	.	PUNCT
gs-4321	23	1	these	these	DET
gs-4321	23	2	innovations	innovation	NOUN
gs-4321	23	3	allow	allow	VERB
gs-4321	23	4	researchers	researcher	NOUN
gs-4321	23	5	to	to	PART
gs-4321	23	6	visualize	visualize	VERB
gs-4321	23	7	cellular	cellular	ADJ
gs-4321	23	8	diversity	diversity	NOUN
gs-4321	23	9	at	at	ADP
gs-4321	23	10	unprecedented	unprecedented	ADJ
gs-4321	23	11	resolution	resolution	NOUN
gs-4321	23	12	,	,	PUNCT
gs-4321	23	13	reconstruct	reconstruct	VERB
gs-4321	23	14	developmental	developmental	ADJ
gs-4321	23	15	trajectories	trajectory	NOUN
gs-4321	23	16	,	,	PUNCT
gs-4321	23	17	infer	infer	VERB
gs-4321	23	18	gene	gene	NOUN
gs-4321	23	19	regulatory	regulatory	ADJ
gs-4321	23	20	networks	network	NOUN
gs-4321	23	21	,	,	PUNCT
gs-4321	23	22	and	and	CCONJ
gs-4321	23	23	quantify	quantify	VERB
gs-4321	23	24	the	the	DET
gs-4321	23	25	impact	impact	NOUN
gs-4321	23	26	of	of	ADP
gs-4321	23	27	microenvironmental	microenvironmental	ADJ
gs-4321	23	28	cues	cue	NOUN
gs-4321	23	29	on	on	ADP
gs-4321	23	30	individual	individual	ADJ
gs-4321	23	31	cells	cell	NOUN
gs-4321	23	32	(	(	PUNCT
gs-4321	23	33	zheng	zheng	X
gs-4321	23	34	et	et	PROPN
gs-4321	23	35	al	al	PROPN
gs-4321	23	36	.	.	PROPN
gs-4321	23	37	,	,	PUNCT
gs-4321	23	38	2017	2017	NUM
gs-4321	23	39	;	;	PUNCT
gs-4321	23	40	stuart	stuart	PROPN
gs-4321	23	41	et	et	PROPN
gs-4321	23	42	al	al	PROPN
gs-4321	23	43	.	.	PROPN
gs-4321	23	44	,	,	PUNCT
gs-4321	23	45	2019	2019	NUM
gs-4321	23	46	)	)	PUNCT
gs-4321	23	47	.	.	PUNCT
gs-4321	24	1	as	as	SCONJ
gs-4321	24	2	single	single	ADJ
gs-4321	24	3	-	-	PUNCT
gs-4321	24	4	cell	cell	NOUN
gs-4321	24	5	datasets	dataset	NOUN
gs-4321	24	6	expand	expand	VERB
gs-4321	24	7	in	in	ADP
gs-4321	24	8	scale	scale	NOUN
gs-4321	24	9	and	and	CCONJ
gs-4321	24	10	complexity	complexity	NOUN
gs-4321	24	11	,	,	PUNCT
gs-4321	24	12	the	the	DET
gs-4321	24	13	interpretation	interpretation	NOUN
gs-4321	24	14	of	of	ADP
gs-4321	24	15	these	these	DET
gs-4321	24	16	data	datum	NOUN
gs-4321	24	17	has	have	AUX
gs-4321	24	18	become	become	VERB
gs-4321	24	19	increasingly	increasingly	ADV
gs-4321	24	20	reliant	reliant	ADJ
gs-4321	24	21	on	on	ADP
gs-4321	24	22	advanced	advanced	ADJ
gs-4321	24	23	computational	computational	ADJ
gs-4321	24	24	strategies	strategy	NOUN
gs-4321	24	25	.	.	PUNCT
gs-4321	25	1	bioinformatics	bioinformatics	NOUN
gs-4321	25	2	frameworks	framework	NOUN
gs-4321	25	3	now	now	ADV
gs-4321	25	4	play	play	VERB
gs-4321	25	5	a	a	DET
gs-4321	25	6	central	central	ADJ
gs-4321	25	7	role	role	NOUN
gs-4321	25	8	in	in	ADP
gs-4321	25	9	harmonizing	harmonize	VERB
gs-4321	25	10	heterogeneous	heterogeneous	ADJ
gs-4321	25	11	datasets	dataset	NOUN
gs-4321	25	12	,	,	PUNCT
gs-4321	25	13	correcting	correct	VERB
gs-4321	25	14	batch	batch	NOUN
gs-4321	25	15	effects	effect	NOUN
gs-4321	25	16	,	,	PUNCT
gs-4321	25	17	quantifying	quantify	VERB
gs-4321	25	18	transcriptional	transcriptional	ADJ
gs-4321	25	19	dynamics	dynamic	NOUN
gs-4321	25	20	,	,	PUNCT
gs-4321	25	21	modeling	model	VERB
gs-4321	25	22	lineage	lineage	NOUN
gs-4321	25	23	bifurcations	bifurcation	NOUN
gs-4321	25	24	,	,	PUNCT
gs-4321	25	25	and	and	CCONJ
gs-4321	25	26	identifying	identify	VERB
gs-4321	25	27	regulators	regulator	NOUN
gs-4321	25	28	of	of	ADP
gs-4321	25	29	cellular	cellular	ADJ
gs-4321	25	30	transitions	transition	NOUN
gs-4321	25	31	.	.	PUNCT
gs-4321	26	1	machine	machine	NOUN
gs-4321	26	2	-	-	PUNCT
gs-4321	26	3	learning	learn	VERB
gs-4321	26	4	and	and	CCONJ
gs-4321	26	5	graph	graph	NOUN
gs-4321	26	6	-	-	PUNCT
gs-4321	26	7	based	base	VERB
gs-4321	26	8	algorithms	algorithm	NOUN
gs-4321	26	9	have	have	AUX
gs-4321	26	10	further	far	ADV
gs-4321	26	11	enhanced	enhance	VERB
gs-4321	26	12	the	the	DET
gs-4321	26	13	ability	ability	NOUN
gs-4321	26	14	to	to	PART
gs-4321	26	15	map	map	VERB
gs-4321	26	16	subtle	subtle	ADJ
gs-4321	26	17	state	state	NOUN
gs-4321	26	18	intermediates	intermediate	NOUN
gs-4321	26	19	that	that	PRON
gs-4321	26	20	would	would	AUX
gs-4321	26	21	traditionally	traditionally	ADV
gs-4321	26	22	remain	remain	VERB
gs-4321	26	23	undetected	undetected	ADJ
gs-4321	26	24	using	use	VERB
gs-4321	26	25	lower	low	ADJ
gs-4321	26	26	-	-	PUNCT
gs-4321	26	27	resolution	resolution	NOUN
gs-4321	26	28	methods	method	NOUN
gs-4321	26	29	(	(	PUNCT
gs-4321	26	30	wolf	wolf	PROPN
gs-4321	26	31	et	et	PROPN
gs-4321	26	32	al	al	PROPN
gs-4321	26	33	.	.	PROPN
gs-4321	26	34	,	,	PUNCT
gs-4321	26	35	2018	2018	NUM
gs-4321	26	36	;	;	PUNCT
gs-4321	26	37	trapnell	trapnell	NOUN
gs-4321	26	38	et	et	PROPN
gs-4321	26	39	al	al	PROPN
gs-4321	26	40	.	.	PROPN
gs-4321	26	41	,	,	PUNCT
gs-4321	26	42	2014	2014	NUM
gs-4321	26	43	)	)	PUNCT
gs-4321	26	44	.	.	PUNCT
gs-4321	27	1	importantly	importantly	ADV
gs-4321	27	2	,	,	PUNCT
gs-4321	27	3	these	these	DET
gs-4321	27	4	computational	computational	ADJ
gs-4321	27	5	advances	advance	NOUN
gs-4321	27	6	provide	provide	VERB
gs-4321	27	7	opportunities	opportunity	NOUN
gs-4321	27	8	not	not	PART
gs-4321	27	9	merely	merely	ADV
gs-4321	27	10	to	to	PART
gs-4321	27	11	describe	describe	VERB
gs-4321	27	12	cellular	cellular	ADJ
gs-4321	27	13	states	state	NOUN
gs-4321	27	14	but	but	CCONJ
gs-4321	27	15	to	to	PART
gs-4321	27	16	infer	infer	VERB
gs-4321	27	17	the	the	DET
gs-4321	27	18	regulatory	regulatory	ADJ
gs-4321	27	19	rules	rule	NOUN
gs-4321	27	20	that	that	PRON
gs-4321	27	21	shape	shape	VERB
gs-4321	27	22	them	they	PRON
gs-4321	27	23	,	,	PUNCT
gs-4321	27	24	offering	offer	VERB
gs-4321	27	25	deep	deep	ADJ
gs-4321	27	26	mechanistic	mechanistic	ADJ
gs-4321	27	27	insight	insight	NOUN
gs-4321	27	28	into	into	ADP
gs-4321	27	29	how	how	SCONJ
gs-4321	27	30	malignant	malignant	ADJ
gs-4321	27	31	cells	cell	NOUN
gs-4321	27	32	shift	shift	VERB
gs-4321	27	33	between	between	ADP
gs-4321	27	34	stem	stem	NOUN
gs-4321	27	35	-	-	PUNCT
gs-4321	27	36	like	like	ADJ
gs-4321	27	37	and	and	CCONJ
gs-4321	27	38	differentiated	differentiated	ADJ
gs-4321	27	39	conditions	condition	NOUN
gs-4321	27	40	.	.	PUNCT
gs-4321	28	1	the	the	DET
gs-4321	28	2	rise	rise	NOUN
gs-4321	28	3	of	of	ADP
gs-4321	28	4	high	high	ADJ
gs-4321	28	5	-	-	PUNCT
gs-4321	28	6	resolution	resolution	NOUN
gs-4321	28	7	cellular	cellular	ADJ
gs-4321	28	8	profiling	profiling	NOUN
gs-4321	28	9	has	have	AUX
gs-4321	28	10	coincided	coincide	VERB
gs-4321	28	11	with	with	ADP
gs-4321	28	12	a	a	DET
gs-4321	28	13	broader	broad	ADJ
gs-4321	28	14	conceptual	conceptual	ADJ
gs-4321	28	15	shift	shift	NOUN
gs-4321	28	16	in	in	ADP
gs-4321	28	17	cancer	cancer	NOUN
gs-4321	28	18	biology	biology	NOUN
gs-4321	28	19	,	,	PUNCT
gs-4321	28	20	emphasizing	emphasize	VERB
gs-4321	28	21	dynamic	dynamic	ADJ
gs-4321	28	22	regulatory	regulatory	ADJ
gs-4321	28	23	systems	system	NOUN
gs-4321	28	24	rather	rather	ADV
gs-4321	28	25	than	than	ADP
gs-4321	28	26	static	static	ADJ
gs-4321	28	27	cellular	cellular	ADJ
gs-4321	28	28	identities	identity	NOUN
gs-4321	28	29	.	.	PUNCT
gs-4321	29	1	early	early	ADJ
gs-4321	29	2	models	model	NOUN
gs-4321	29	3	proposed	propose	VERB
gs-4321	29	4	that	that	SCONJ
gs-4321	29	5	stem	stem	NOUN
gs-4321	29	6	-	-	PUNCT
gs-4321	29	7	like	like	ADJ
gs-4321	29	8	malignant	malignant	ADJ
gs-4321	29	9	cells	cell	NOUN
gs-4321	29	10	represented	represent	VERB
gs-4321	29	11	a	a	DET
gs-4321	29	12	fixed	fix	VERB
gs-4321	29	13	,	,	PUNCT
gs-4321	29	14	hierarchically	hierarchically	ADV
gs-4321	29	15	superior	superior	ADJ
gs-4321	29	16	subpopulation	subpopulation	NOUN
gs-4321	29	17	within	within	ADP
gs-4321	29	18	tumors	tumor	NOUN
gs-4321	29	19	.	.	PUNCT
gs-4321	30	1	however	however	ADV
gs-4321	30	2	,	,	PUNCT
gs-4321	30	3	accumulating	accumulate	VERB
gs-4321	30	4	evidence	evidence	NOUN
gs-4321	30	5	reveals	reveal	VERB
gs-4321	30	6	that	that	SCONJ
gs-4321	30	7	stem	stem	NOUN
gs-4321	30	8	-	-	PUNCT
gs-4321	30	9	associated	associate	VERB
gs-4321	30	10	features	feature	NOUN
gs-4321	30	11	can	can	AUX
gs-4321	30	12	be	be	AUX
gs-4321	30	13	acquired	acquire	VERB
gs-4321	30	14	,	,	PUNCT
gs-4321	30	15	suppressed	suppress	VERB
gs-4321	30	16	,	,	PUNCT
gs-4321	30	17	or	or	CCONJ
gs-4321	30	18	reactivated	reactivate	VERB
gs-4321	30	19	in	in	ADP
gs-4321	30	20	response	response	NOUN
gs-4321	30	21	to	to	ADP
gs-4321	30	22	microenvironmental	microenvironmental	ADJ
gs-4321	30	23	cues	cue	NOUN
gs-4321	30	24	,	,	PUNCT
gs-4321	30	25	inflammatory	inflammatory	ADJ
gs-4321	30	26	signals	signal	NOUN
gs-4321	30	27	,	,	PUNCT
gs-4321	30	28	metabolic	metabolic	NOUN
gs-4321	30	29	stress	stress	NOUN
gs-4321	30	30	,	,	PUNCT
gs-4321	30	31	and	and	CCONJ
gs-4321	30	32	therapeutic	therapeutic	ADJ
gs-4321	30	33	exposure	exposure	NOUN
gs-4321	30	34	(	(	PUNCT
gs-4321	30	35	shibue	shibue	NOUN
gs-4321	30	36	and	and	CCONJ
gs-4321	30	37	weinberg	weinberg	PROPN
gs-4321	30	38	,	,	PUNCT
gs-4321	30	39	2017	2017	NUM
gs-4321	30	40	;	;	PUNCT
gs-4321	30	41	quintanal	quintanal	ADJ
gs-4321	30	42	-	-	PUNCT
gs-4321	30	43	villalonga	villalonga	NOUN
gs-4321	30	44	et	et	NOUN
gs-4321	30	45	al	al	PROPN
gs-4321	30	46	.	.	PROPN
gs-4321	30	47	,	,	PUNCT
gs-4321	30	48	2020	2020	NUM
gs-4321	30	49	)	)	PUNCT
gs-4321	30	50	.	.	PUNCT
gs-4321	31	1	this	this	PRON
gs-4321	31	2	revised	revise	VERB
gs-4321	31	3	perspective	perspective	NOUN
gs-4321	31	4	positions	position	NOUN
gs-4321	31	5	plasticity	plasticity	NOUN
gs-4321	31	6	—	—	PUNCT
gs-4321	31	7	not	not	PART
gs-4321	31	8	inherent	inherent	ADJ
gs-4321	31	9	stemness	stemness	NOUN
gs-4321	31	10	—	—	PUNCT
gs-4321	31	11	as	as	ADP
gs-4321	31	12	the	the	DET
gs-4321	31	13	defining	define	VERB
gs-4321	31	14	feature	feature	NOUN
gs-4321	31	15	that	that	PRON
gs-4321	31	16	enables	enable	VERB
gs-4321	31	17	malignant	malignant	ADJ
gs-4321	31	18	cells	cell	NOUN
gs-4321	31	19	to	to	PART
gs-4321	31	20	survive	survive	VERB
gs-4321	31	21	selective	selective	ADJ
gs-4321	31	22	pressures	pressure	NOUN
gs-4321	31	23	and	and	CCONJ
gs-4321	31	24	reconstitute	reconstitute	VERB
gs-4321	31	25	tumor	tumor	NOUN
gs-4321	31	26	architecture	architecture	NOUN
gs-4321	31	27	georgian	georgian	NOUN
gs-4321	31	28	scientists/	scientists/	NUM
gs-4321	31	29	.	.	PUNCT
gs-4321	32	1	7	7	NUM
gs-4321	32	2	n	n	DET
gs-4321	32	3	4	4	NUM
gs-4321	32	4	,	,	PUNCT
gs-4321	32	5	2025	2025	NUM
gs-4321	32	6	336	336	NUM
gs-4321	32	7	following	follow	VERB
gs-4321	32	8	treatment	treatment	NOUN
gs-4321	32	9	.	.	PUNCT
gs-4321	33	1	such	such	ADJ
gs-4321	33	2	observations	observation	NOUN
gs-4321	33	3	highlight	highlight	VERB
gs-4321	33	4	the	the	DET
gs-4321	33	5	need	need	NOUN
gs-4321	33	6	to	to	PART
gs-4321	33	7	dissect	dissect	VERB
gs-4321	33	8	the	the	DET
gs-4321	33	9	molecular	molecular	ADJ
gs-4321	33	10	processes	process	NOUN
gs-4321	33	11	underlying	underlie	VERB
gs-4321	33	12	state	state	NOUN
gs-4321	33	13	transitions	transition	NOUN
gs-4321	33	14	,	,	PUNCT
gs-4321	33	15	rather	rather	ADV
gs-4321	33	16	than	than	ADP
gs-4321	33	17	solely	solely	ADV
gs-4321	33	18	cataloging	catalog	VERB
gs-4321	33	19	stem	stem	NOUN
gs-4321	33	20	-	-	PUNCT
gs-4321	33	21	like	like	ADJ
gs-4321	33	22	markers	marker	NOUN
gs-4321	33	23	.	.	PUNCT
gs-4321	34	1	single	single	ADJ
gs-4321	34	2	-	-	PUNCT
gs-4321	34	3	cell	cell	NOUN
gs-4321	34	4	profiling	profiling	NOUN
gs-4321	34	5	has	have	AUX
gs-4321	34	6	been	be	AUX
gs-4321	34	7	instrumental	instrumental	ADJ
gs-4321	34	8	in	in	ADP
gs-4321	34	9	demonstrating	demonstrate	VERB
gs-4321	34	10	the	the	DET
gs-4321	34	11	fluidity	fluidity	NOUN
gs-4321	34	12	of	of	ADP
gs-4321	34	13	malignant	malignant	ADJ
gs-4321	34	14	phenotypes	phenotype	NOUN
gs-4321	34	15	.	.	PUNCT
gs-4321	35	1	for	for	ADP
gs-4321	35	2	example	example	NOUN
gs-4321	35	3	,	,	PUNCT
gs-4321	35	4	studies	study	NOUN
gs-4321	35	5	in	in	ADP
gs-4321	35	6	glioblastoma	glioblastoma	NOUN
gs-4321	35	7	have	have	AUX
gs-4321	35	8	identified	identify	VERB
gs-4321	35	9	highly	highly	ADV
gs-4321	35	10	adaptable	adaptable	ADJ
gs-4321	35	11	subpopulations	subpopulation	NOUN
gs-4321	35	12	capable	capable	ADJ
gs-4321	35	13	of	of	ADP
gs-4321	35	14	oscillating	oscillate	VERB
gs-4321	35	15	between	between	ADP
gs-4321	35	16	neural	neural	ADJ
gs-4321	35	17	progenitor	progenitor	NOUN
gs-4321	35	18	–	–	PUNCT
gs-4321	35	19	like	like	ADJ
gs-4321	35	20	,	,	PUNCT
gs-4321	35	21	mesenchymal	mesenchymal	NOUN
gs-4321	35	22	,	,	PUNCT
gs-4321	35	23	and	and	CCONJ
gs-4321	35	24	astrocyte	astrocyte	NOUN
gs-4321	35	25	-	-	PUNCT
gs-4321	35	26	like	like	ADJ
gs-4321	35	27	states	state	NOUN
gs-4321	35	28	,	,	PUNCT
gs-4321	35	29	often	often	ADV
gs-4321	35	30	driven	drive	VERB
gs-4321	35	31	by	by	ADP
gs-4321	35	32	injury	injury	NOUN
gs-4321	35	33	-	-	PUNCT
gs-4321	35	34	associated	associate	VERB
gs-4321	35	35	cytokine	cytokine	NOUN
gs-4321	35	36	signaling	signal	VERB
gs-4321	35	37	(	(	PUNCT
gs-4321	35	38	neftel	neftel	NOUN
gs-4321	35	39	et	et	PROPN
gs-4321	35	40	al	al	PROPN
gs-4321	35	41	.	.	PROPN
gs-4321	35	42	,	,	PUNCT
gs-4321	35	43	2019	2019	NUM
gs-4321	35	44	)	)	PUNCT
gs-4321	35	45	.	.	PUNCT
gs-4321	36	1	similar	similar	ADJ
gs-4321	36	2	analyses	analysis	NOUN
gs-4321	36	3	in	in	ADP
gs-4321	36	4	breast	breast	NOUN
gs-4321	36	5	cancer	cancer	NOUN
gs-4321	36	6	and	and	CCONJ
gs-4321	36	7	melanoma	melanoma	NOUN
gs-4321	36	8	reveal	reveal	VERB
gs-4321	36	9	transcriptional	transcriptional	ADJ
gs-4321	36	10	programs	program	NOUN
gs-4321	36	11	enabling	enable	VERB
gs-4321	36	12	transitions	transition	NOUN
gs-4321	36	13	between	between	ADP
gs-4321	36	14	proliferative	proliferative	ADJ
gs-4321	36	15	,	,	PUNCT
gs-4321	36	16	dormant	dormant	ADJ
gs-4321	36	17	,	,	PUNCT
gs-4321	36	18	invasive	invasive	ADJ
gs-4321	36	19	,	,	PUNCT
gs-4321	36	20	and	and	CCONJ
gs-4321	36	21	drug	drug	NOUN
gs-4321	36	22	-	-	PUNCT
gs-4321	36	23	tolerant	tolerant	ADJ
gs-4321	36	24	persister	persister	NOUN
gs-4321	36	25	states	state	NOUN
gs-4321	36	26	(	(	PUNCT
gs-4321	36	27	rambow	rambow	PROPN
gs-4321	36	28	et	et	PROPN
gs-4321	36	29	al	al	PROPN
gs-4321	36	30	.	.	PROPN
gs-4321	36	31	,	,	PUNCT
gs-4321	36	32	2018	2018	NUM
gs-4321	36	33	;	;	PUNCT
gs-4321	36	34	sharma	sharma	PROPN
gs-4321	36	35	et	et	PROPN
gs-4321	36	36	al	al	PROPN
gs-4321	36	37	.	.	PROPN
gs-4321	36	38	,	,	PUNCT
gs-4321	36	39	2010	2010	NUM
gs-4321	36	40	)	)	PUNCT
gs-4321	36	41	.	.	PUNCT
gs-4321	37	1	importantly	importantly	ADV
gs-4321	37	2	,	,	PUNCT
gs-4321	37	3	these	these	DET
gs-4321	37	4	transitions	transition	NOUN
gs-4321	37	5	are	be	AUX
gs-4321	37	6	not	not	PART
gs-4321	37	7	stochastic	stochastic	ADJ
gs-4321	37	8	but	but	CCONJ
gs-4321	37	9	are	be	AUX
gs-4321	37	10	orchestrated	orchestrate	VERB
gs-4321	37	11	by	by	ADP
gs-4321	37	12	defined	define	VERB
gs-4321	37	13	regulatory	regulatory	ADJ
gs-4321	37	14	circuits	circuit	NOUN
gs-4321	37	15	involving	involve	VERB
gs-4321	37	16	chromatin	chromatin	NOUN
gs-4321	37	17	remodeling	remodeling	NOUN
gs-4321	37	18	enzymes	enzyme	NOUN
gs-4321	37	19	,	,	PUNCT
gs-4321	37	20	stress	stress	NOUN
gs-4321	37	21	-	-	PUNCT
gs-4321	37	22	responsive	responsive	ADJ
gs-4321	37	23	transcription	transcription	NOUN
gs-4321	37	24	factors	factor	NOUN
gs-4321	37	25	,	,	PUNCT
gs-4321	37	26	metabolic	metabolic	NOUN
gs-4321	37	27	rewiring	rewiring	NOUN
gs-4321	37	28	,	,	PUNCT
gs-4321	37	29	and	and	CCONJ
gs-4321	37	30	microenvironment	microenvironment	NOUN
gs-4321	37	31	-	-	PUNCT
gs-4321	37	32	derived	derive	VERB
gs-4321	37	33	signals	signal	NOUN
gs-4321	37	34	such	such	ADJ
gs-4321	37	35	as	as	ADP
gs-4321	37	36	tgf	tgf	PROPN
gs-4321	37	37	,	,	PUNCT
gs-4321	37	38	il-6	il-6	NOUN
gs-4321	37	39	,	,	PUNCT
gs-4321	37	40	and	and	CCONJ
gs-4321	37	41	wnt	wnt	PROPN
gs-4321	37	42	ligands	ligand	NOUN
gs-4321	37	43	.	.	PUNCT
gs-4321	38	1	deciphering	decipher	VERB
gs-4321	38	2	these	these	DET
gs-4321	38	3	circuits	circuit	NOUN
gs-4321	38	4	requires	require	VERB
gs-4321	38	5	computational	computational	ADJ
gs-4321	38	6	approaches	approach	NOUN
gs-4321	38	7	capable	capable	ADJ
gs-4321	38	8	of	of	ADP
gs-4321	38	9	integrating	integrate	VERB
gs-4321	38	10	multiple	multiple	ADJ
gs-4321	38	11	layers	layer	NOUN
gs-4321	38	12	of	of	ADP
gs-4321	38	13	biological	biological	ADJ
gs-4321	38	14	information	information	NOUN
gs-4321	38	15	.	.	PUNCT
gs-4321	39	1	bioinformatics	bioinformatic	NOUN
gs-4321	39	2	has	have	AUX
gs-4321	39	3	emerged	emerge	VERB
gs-4321	39	4	as	as	ADP
gs-4321	39	5	a	a	DET
gs-4321	39	6	critical	critical	ADJ
gs-4321	39	7	tool	tool	NOUN
gs-4321	39	8	for	for	ADP
gs-4321	39	9	reconstructing	reconstruct	VERB
gs-4321	39	10	these	these	DET
gs-4321	39	11	regulatory	regulatory	ADJ
gs-4321	39	12	processes	process	NOUN
gs-4321	39	13	.	.	PUNCT
gs-4321	40	1	algorithms	algorithm	NOUN
gs-4321	40	2	for	for	ADP
gs-4321	40	3	trajectory	trajectory	NOUN
gs-4321	40	4	inference	inference	NOUN
gs-4321	40	5	reveal	reveal	VERB
gs-4321	40	6	pseudotemporal	pseudotemporal	ADJ
gs-4321	40	7	pathways	pathway	NOUN
gs-4321	40	8	through	through	ADP
gs-4321	40	9	which	which	PRON
gs-4321	40	10	cells	cell	NOUN
gs-4321	40	11	evolve	evolve	VERB
gs-4321	40	12	,	,	PUNCT
gs-4321	40	13	enabling	enable	VERB
gs-4321	40	14	researchers	researcher	NOUN
gs-4321	40	15	to	to	PART
gs-4321	40	16	characterize	characterize	VERB
gs-4321	40	17	previously	previously	ADV
gs-4321	40	18	unrecognized	unrecognize	VERB
gs-4321	40	19	intermediates	intermediate	NOUN
gs-4321	40	20	and	and	CCONJ
gs-4321	40	21	branching	branch	VERB
gs-4321	40	22	decision	decision	NOUN
gs-4321	40	23	points	point	NOUN
gs-4321	40	24	(	(	PUNCT
gs-4321	40	25	saelens	saelen	NOUN
gs-4321	40	26	et	et	PROPN
gs-4321	40	27	al	al	PROPN
gs-4321	40	28	.	.	PROPN
gs-4321	40	29	,	,	PUNCT
gs-4321	40	30	2019	2019	NUM
gs-4321	40	31	)	)	PUNCT
gs-4321	40	32	.	.	PUNCT
gs-4321	41	1	in	in	ADP
gs-4321	41	2	parallel	parallel	NOUN
gs-4321	41	3	,	,	PUNCT
gs-4321	41	4	gene	gene	NOUN
gs-4321	41	5	regulatory	regulatory	ADJ
gs-4321	41	6	network	network	NOUN
gs-4321	41	7	–	–	PUNCT
gs-4321	41	8	based	base	VERB
gs-4321	41	9	approaches	approach	NOUN
gs-4321	41	10	—	—	PUNCT
gs-4321	41	11	such	such	ADJ
gs-4321	41	12	as	as	ADP
gs-4321	41	13	scenic	scenic	ADJ
gs-4321	41	14	,	,	PUNCT
gs-4321	41	15	inferelator	inferelator	NOUN
gs-4321	41	16	,	,	PUNCT
gs-4321	41	17	and	and	CCONJ
gs-4321	41	18	grnboost	grnboost	NOUN
gs-4321	41	19	—	—	PUNCT
gs-4321	41	20	identify	identify	VERB
gs-4321	41	21	transcription	transcription	NOUN
gs-4321	41	22	factor	factor	NOUN
gs-4321	41	23	modules	module	NOUN
gs-4321	41	24	that	that	PRON
gs-4321	41	25	drive	drive	VERB
gs-4321	41	26	these	these	DET
gs-4321	41	27	transitions	transition	NOUN
gs-4321	41	28	,	,	PUNCT
gs-4321	41	29	while	while	SCONJ
gs-4321	41	30	chromatin	chromatin	NOUN
gs-4321	41	31	accessibility	accessibility	NOUN
gs-4321	41	32	datasets	dataset	NOUN
gs-4321	41	33	provide	provide	VERB
gs-4321	41	34	complementary	complementary	ADJ
gs-4321	41	35	insight	insight	NOUN
gs-4321	41	36	into	into	ADP
gs-4321	41	37	epigenetic	epigenetic	ADJ
gs-4321	41	38	determinants	determinant	NOUN
gs-4321	41	39	of	of	ADP
gs-4321	41	40	cell	cell	NOUN
gs-4321	41	41	-	-	PUNCT
gs-4321	41	42	state	state	NOUN
gs-4321	41	43	plasticity	plasticity	NOUN
gs-4321	41	44	(	(	PUNCT
gs-4321	41	45	aibar	aibar	PROPN
gs-4321	41	46	et	et	PROPN
gs-4321	41	47	al	al	PROPN
gs-4321	41	48	.	.	PROPN
gs-4321	41	49	,	,	PUNCT
gs-4321	41	50	2017	2017	NUM
gs-4321	41	51	;	;	PUNCT
gs-4321	41	52	cusanovich	cusanovich	PROPN
gs-4321	41	53	et	et	PROPN
gs-4321	41	54	al	al	PROPN
gs-4321	41	55	.	.	PROPN
gs-4321	41	56	,	,	PUNCT
gs-4321	41	57	2018	2018	NUM
gs-4321	41	58	)	)	PUNCT
gs-4321	41	59	.	.	PUNCT
gs-4321	42	1	these	these	DET
gs-4321	42	2	computational	computational	ADJ
gs-4321	42	3	advances	advance	NOUN
gs-4321	42	4	allow	allow	VERB
gs-4321	42	5	for	for	ADP
gs-4321	42	6	a	a	DET
gs-4321	42	7	molecularly	molecularly	ADV
gs-4321	42	8	resolved	resolve	VERB
gs-4321	42	9	picture	picture	NOUN
gs-4321	42	10	of	of	ADP
gs-4321	42	11	how	how	SCONJ
gs-4321	42	12	environmental	environmental	ADJ
gs-4321	42	13	stressors	stressor	NOUN
gs-4321	42	14	or	or	CCONJ
gs-4321	42	15	therapeutic	therapeutic	ADJ
gs-4321	42	16	interventions	intervention	NOUN
gs-4321	42	17	direct	direct	ADJ
gs-4321	42	18	malignant	malignant	ADJ
gs-4321	42	19	cells	cell	NOUN
gs-4321	42	20	toward	toward	ADP
gs-4321	42	21	or	or	CCONJ
gs-4321	42	22	away	away	ADV
gs-4321	42	23	from	from	ADP
gs-4321	42	24	stem	stem	NOUN
gs-4321	42	25	-	-	PUNCT
gs-4321	42	26	like	like	ADJ
gs-4321	42	27	configurations	configuration	NOUN
gs-4321	42	28	.	.	PUNCT
gs-4321	43	1	the	the	DET
gs-4321	43	2	tumor	tumor	NOUN
gs-4321	43	3	microenvironment	microenvironment	NOUN
gs-4321	43	4	further	far	ADV
gs-4321	43	5	amplifies	amplify	VERB
gs-4321	43	6	the	the	DET
gs-4321	43	7	complexity	complexity	NOUN
gs-4321	43	8	of	of	ADP
gs-4321	43	9	these	these	DET
gs-4321	43	10	transitions	transition	NOUN
gs-4321	43	11	.	.	PUNCT
gs-4321	44	1	stromal	stromal	ADJ
gs-4321	44	2	cells	cell	NOUN
gs-4321	44	3	,	,	PUNCT
gs-4321	44	4	infiltrating	infiltrating	ADJ
gs-4321	44	5	immune	immune	ADJ
gs-4321	44	6	populations	population	NOUN
gs-4321	44	7	,	,	PUNCT
gs-4321	44	8	endothelial	endothelial	NOUN
gs-4321	44	9	niches	niche	NOUN
gs-4321	44	10	,	,	PUNCT
gs-4321	44	11	and	and	CCONJ
gs-4321	44	12	extracellular	extracellular	ADJ
gs-4321	44	13	vesicles	vesicle	NOUN
gs-4321	44	14	cooperate	cooperate	VERB
gs-4321	44	15	to	to	PART
gs-4321	44	16	regulate	regulate	VERB
gs-4321	44	17	the	the	DET
gs-4321	44	18	phenotypic	phenotypic	ADJ
gs-4321	44	19	landscape	landscape	NOUN
gs-4321	44	20	of	of	ADP
gs-4321	44	21	malignant	malignant	ADJ
gs-4321	44	22	cells	cell	NOUN
gs-4321	44	23	.	.	PUNCT
gs-4321	45	1	cell	cell	NOUN
gs-4321	45	2	–	–	PUNCT
gs-4321	45	3	cell	cell	NOUN
gs-4321	45	4	communication	communication	NOUN
gs-4321	45	5	modeling	modeling	NOUN
gs-4321	45	6	tools	tool	NOUN
gs-4321	45	7	such	such	ADJ
gs-4321	45	8	as	as	ADP
gs-4321	45	9	cellphonedb	cellphonedb	NOUN
gs-4321	45	10	,	,	PUNCT
gs-4321	45	11	nichenet	nichenet	NOUN
gs-4321	45	12	,	,	PUNCT
gs-4321	45	13	and	and	CCONJ
gs-4321	45	14	cellchat	cellchat	PROPN
gs-4321	45	15	have	have	AUX
gs-4321	45	16	revealed	reveal	VERB
gs-4321	45	17	that	that	SCONJ
gs-4321	45	18	reciprocal	reciprocal	ADJ
gs-4321	45	19	ligand	ligand	NOUN
gs-4321	45	20	–	–	PUNCT
gs-4321	45	21	receptor	receptor	NOUN
gs-4321	45	22	interactions	interaction	NOUN
gs-4321	45	23	can	can	AUX
gs-4321	45	24	activate	activate	VERB
gs-4321	45	25	transcriptional	transcriptional	ADJ
gs-4321	45	26	programs	program	NOUN
gs-4321	45	27	that	that	PRON
gs-4321	45	28	sustain	sustain	VERB
gs-4321	45	29	stemassociated	stemassociate	VERB
gs-4321	45	30	traits	trait	NOUN
gs-4321	45	31	or	or	CCONJ
gs-4321	45	32	drive	drive	VERB
gs-4321	45	33	state	state	NOUN
gs-4321	45	34	interconversion	interconversion	NOUN
gs-4321	45	35	(	(	PUNCT
gs-4321	45	36	browaeys	browaey	NOUN
gs-4321	45	37	et	et	PROPN
gs-4321	45	38	al	al	PROPN
gs-4321	45	39	.	.	PROPN
gs-4321	45	40	,	,	PUNCT
gs-4321	45	41	2020	2020	NUM
gs-4321	45	42	;	;	PUNCT
gs-4321	45	43	efremova	efremova	PROPN
gs-4321	45	44	et	et	PROPN
gs-4321	45	45	al	al	PROPN
gs-4321	45	46	.	.	PROPN
gs-4321	45	47	,	,	PUNCT
gs-4321	45	48	2020	2020	NUM
gs-4321	45	49	)	)	PUNCT
gs-4321	45	50	.	.	PUNCT
gs-4321	46	1	these	these	DET
gs-4321	46	2	insights	insight	NOUN
gs-4321	46	3	underscore	underscore	VERB
gs-4321	46	4	the	the	DET
gs-4321	46	5	importance	importance	NOUN
gs-4321	46	6	of	of	ADP
gs-4321	46	7	integrating	integrate	VERB
gs-4321	46	8	intercellular	intercellular	ADJ
gs-4321	46	9	signaling	signal	VERB
gs-4321	46	10	analyses	analysis	NOUN
gs-4321	46	11	into	into	ADP
gs-4321	46	12	the	the	DET
gs-4321	46	13	study	study	NOUN
gs-4321	46	14	of	of	ADP
gs-4321	46	15	plasticity	plasticity	NOUN
gs-4321	46	16	,	,	PUNCT
gs-4321	46	17	as	as	SCONJ
gs-4321	46	18	stem	stem	NOUN
gs-4321	46	19	-	-	PUNCT
gs-4321	46	20	like	like	ADJ
gs-4321	46	21	phenotypes	phenotype	NOUN
gs-4321	46	22	often	often	ADV
gs-4321	46	23	arise	arise	VERB
gs-4321	46	24	from	from	ADP
gs-4321	46	25	niche	niche	NOUN
gs-4321	46	26	-	-	PUNCT
gs-4321	46	27	dependent	dependent	ADJ
gs-4321	46	28	cues	cue	NOUN
gs-4321	46	29	rather	rather	ADV
gs-4321	46	30	than	than	ADP
gs-4321	46	31	purely	purely	ADV
gs-4321	46	32	intrinsic	intrinsic	ADJ
gs-4321	46	33	changes	change	NOUN
gs-4321	46	34	.	.	PUNCT
gs-4321	47	1	as	as	SCONJ
gs-4321	47	2	advanced	advanced	ADJ
gs-4321	47	3	computational	computational	ADJ
gs-4321	47	4	methods	method	NOUN
gs-4321	47	5	continue	continue	VERB
gs-4321	47	6	to	to	PART
gs-4321	47	7	expand	expand	VERB
gs-4321	47	8	the	the	DET
gs-4321	47	9	analytical	analytical	ADJ
gs-4321	47	10	capacity	capacity	NOUN
gs-4321	47	11	of	of	ADP
gs-4321	47	12	singlecell	singlecell	NOUN
gs-4321	47	13	datasets	dataset	NOUN
gs-4321	47	14	,	,	PUNCT
gs-4321	47	15	attention	attention	NOUN
gs-4321	47	16	has	have	AUX
gs-4321	47	17	increasingly	increasingly	ADV
gs-4321	47	18	turned	turn	VERB
gs-4321	47	19	toward	toward	ADP
gs-4321	47	20	understanding	understand	VERB
gs-4321	47	21	the	the	DET
gs-4321	47	22	temporal	temporal	ADJ
gs-4321	47	23	dimension	dimension	NOUN
gs-4321	47	24	of	of	ADP
gs-4321	47	25	phenotypic	phenotypic	ADJ
gs-4321	47	26	transitions	transition	NOUN
gs-4321	47	27	.	.	PUNCT
gs-4321	48	1	malignant	malignant	ADJ
gs-4321	48	2	cells	cell	NOUN
gs-4321	48	3	frequently	frequently	ADV
gs-4321	48	4	exhibit	exhibit	VERB
gs-4321	48	5	cycles	cycle	NOUN
gs-4321	48	6	of	of	ADP
gs-4321	48	7	growth	growth	NOUN
gs-4321	48	8	,	,	PUNCT
gs-4321	48	9	quiescence	quiescence	NOUN
gs-4321	48	10	,	,	PUNCT
gs-4321	48	11	therapy	therapy	NOUN
gs-4321	48	12	-	-	PUNCT
gs-4321	48	13	induced	induce	VERB
gs-4321	48	14	dormancy	dormancy	NOUN
gs-4321	48	15	,	,	PUNCT
gs-4321	48	16	and	and	CCONJ
gs-4321	48	17	reactivation	reactivation	NOUN
gs-4321	48	18	,	,	PUNCT
gs-4321	48	19	with	with	ADP
gs-4321	48	20	each	each	DET
gs-4321	48	21	state	state	NOUN
gs-4321	48	22	associated	associate	VERB
gs-4321	48	23	with	with	ADP
gs-4321	48	24	specific	specific	ADJ
gs-4321	48	25	transcriptional	transcriptional	NOUN
gs-4321	48	26	and	and	CCONJ
gs-4321	48	27	metabolic	metabolic	NOUN
gs-4321	48	28	profiles	profile	NOUN
gs-4321	48	29	.	.	PUNCT
gs-4321	49	1	pseudotime	pseudotime	ADJ
gs-4321	49	2	algorithms	algorithm	NOUN
gs-4321	49	3	provide	provide	VERB
gs-4321	49	4	a	a	DET
gs-4321	49	5	powerful	powerful	ADJ
gs-4321	49	6	means	mean	NOUN
gs-4321	49	7	of	of	ADP
gs-4321	49	8	positioning	position	VERB
gs-4321	49	9	individual	individual	ADJ
gs-4321	49	10	cells	cell	NOUN
gs-4321	49	11	along	along	ADP
gs-4321	49	12	inferred	infer	VERB
gs-4321	49	13	developmental	developmental	ADJ
gs-4321	49	14	or	or	CCONJ
gs-4321	49	15	transitional	transitional	ADJ
gs-4321	49	16	georgian	georgian	NOUN
gs-4321	49	17	scientists/	scientists/	NUM
gs-4321	49	18	.	.	PUNCT
gs-4321	50	1	7	7	NUM
gs-4321	50	2	n	n	DET
gs-4321	50	3	4	4	NUM
gs-4321	50	4	,	,	PUNCT
gs-4321	50	5	2025	2025	NUM
gs-4321	50	6	337	337	NUM
gs-4321	50	7	trajectories	trajectory	NOUN
gs-4321	50	8	,	,	PUNCT
gs-4321	50	9	but	but	CCONJ
gs-4321	50	10	recent	recent	ADJ
gs-4321	50	11	enhancements	enhancement	NOUN
gs-4321	50	12	—	—	PUNCT
gs-4321	50	13	including	include	VERB
gs-4321	50	14	rna	rna	NOUN
gs-4321	50	15	velocity	velocity	NOUN
gs-4321	50	16	,	,	PUNCT
gs-4321	50	17	metabolic	metabolic	NOUN
gs-4321	50	18	flux	flux	PROPN
gs-4321	50	19	prediction	prediction	NOUN
gs-4321	50	20	,	,	PUNCT
gs-4321	50	21	and	and	CCONJ
gs-4321	50	22	dynamic	dynamic	ADJ
gs-4321	50	23	regulatory	regulatory	ADJ
gs-4321	50	24	modeling	modeling	NOUN
gs-4321	50	25	—	—	PUNCT
gs-4321	50	26	enable	enable	VERB
gs-4321	50	27	more	more	ADV
gs-4321	50	28	precise	precise	ADJ
gs-4321	50	29	analysis	analysis	NOUN
gs-4321	50	30	of	of	ADP
gs-4321	50	31	directionality	directionality	NOUN
gs-4321	50	32	and	and	CCONJ
gs-4321	50	33	rate	rate	NOUN
gs-4321	50	34	of	of	ADP
gs-4321	50	35	change	change	NOUN
gs-4321	50	36	(	(	PUNCT
gs-4321	50	37	la	la	PROPN
gs-4321	50	38	manno	manno	PROPN
gs-4321	50	39	et	et	PROPN
gs-4321	50	40	al	al	PROPN
gs-4321	50	41	.	.	PROPN
gs-4321	50	42	,	,	PUNCT
gs-4321	50	43	2018	2018	NUM
gs-4321	50	44	;	;	PUNCT
gs-4321	50	45	bergen	bergen	PROPN
gs-4321	50	46	et	et	PROPN
gs-4321	50	47	al	al	PROPN
gs-4321	50	48	.	.	PROPN
gs-4321	50	49	,	,	PUNCT
gs-4321	50	50	2020	2020	NUM
gs-4321	50	51	)	)	PUNCT
gs-4321	50	52	.	.	PUNCT
gs-4321	51	1	these	these	DET
gs-4321	51	2	tools	tool	NOUN
gs-4321	51	3	are	be	AUX
gs-4321	51	4	especially	especially	ADV
gs-4321	51	5	relevant	relevant	ADJ
gs-4321	51	6	in	in	ADP
gs-4321	51	7	the	the	DET
gs-4321	51	8	context	context	NOUN
gs-4321	51	9	of	of	ADP
gs-4321	51	10	adaptable	adaptable	ADJ
gs-4321	51	11	subpopulations	subpopulation	NOUN
gs-4321	51	12	,	,	PUNCT
gs-4321	51	13	as	as	SCONJ
gs-4321	51	14	they	they	PRON
gs-4321	51	15	illuminate	illuminate	VERB
gs-4321	51	16	the	the	DET
gs-4321	51	17	continuum	continuum	NOUN
gs-4321	51	18	between	between	ADP
gs-4321	51	19	stemlike	stemlike	ADJ
gs-4321	51	20	and	and	CCONJ
gs-4321	51	21	differentiated	differentiated	ADJ
gs-4321	51	22	states	state	NOUN
gs-4321	51	23	rather	rather	ADV
gs-4321	51	24	than	than	ADP
gs-4321	51	25	imposing	impose	VERB
gs-4321	51	26	rigid	rigid	ADJ
gs-4321	51	27	categories	category	NOUN
gs-4321	51	28	.	.	PUNCT
gs-4321	52	1	in	in	ADP
gs-4321	52	2	several	several	ADJ
gs-4321	52	3	malignancies	malignancy	NOUN
gs-4321	52	4	,	,	PUNCT
gs-4321	52	5	rna	rna	NOUN
gs-4321	52	6	velocity	velocity	NOUN
gs-4321	52	7	approaches	approach	NOUN
gs-4321	52	8	have	have	AUX
gs-4321	52	9	revealed	reveal	VERB
gs-4321	52	10	bidirectional	bidirectional	ADJ
gs-4321	52	11	transitions	transition	NOUN
gs-4321	52	12	,	,	PUNCT
gs-4321	52	13	supporting	support	VERB
gs-4321	52	14	the	the	DET
gs-4321	52	15	concept	concept	NOUN
gs-4321	52	16	that	that	PRON
gs-4321	52	17	stem	stem	NOUN
gs-4321	52	18	-	-	PUNCT
gs-4321	52	19	associated	associate	VERB
gs-4321	52	20	states	state	NOUN
gs-4321	52	21	are	be	AUX
gs-4321	52	22	not	not	PART
gs-4321	52	23	fixed	fix	VERB
gs-4321	52	24	but	but	CCONJ
gs-4321	52	25	can	can	AUX
gs-4321	52	26	be	be	AUX
gs-4321	52	27	reacquired	reacquire	VERB
gs-4321	52	28	following	follow	VERB
gs-4321	52	29	differentiated	differentiated	ADJ
gs-4321	52	30	phases	phase	NOUN
gs-4321	52	31	or	or	CCONJ
gs-4321	52	32	drug	drug	NOUN
gs-4321	52	33	exposure	exposure	NOUN
gs-4321	52	34	.	.	PUNCT
gs-4321	53	1	for	for	ADP
gs-4321	53	2	instance	instance	NOUN
gs-4321	53	3	,	,	PUNCT
gs-4321	53	4	melanoma	melanoma	NOUN
gs-4321	53	5	cells	cell	NOUN
gs-4321	53	6	transitioning	transition	VERB
gs-4321	53	7	between	between	ADP
gs-4321	53	8	proliferative	proliferative	ADJ
gs-4321	53	9	and	and	CCONJ
gs-4321	53	10	invasive	invasive	ADJ
gs-4321	53	11	states	state	NOUN
gs-4321	53	12	display	display	VERB
gs-4321	53	13	reversible	reversible	ADJ
gs-4321	53	14	trajectories	trajectory	NOUN
gs-4321	53	15	driven	drive	VERB
gs-4321	53	16	by	by	ADP
gs-4321	53	17	mitf	mitf	NOUN
gs-4321	53	18	and	and	CCONJ
gs-4321	53	19	axl	axl	VERB
gs-4321	53	20	regulatory	regulatory	ADJ
gs-4321	53	21	programs	program	NOUN
gs-4321	53	22	,	,	PUNCT
gs-4321	53	23	while	while	SCONJ
gs-4321	53	24	leukemia	leukemia	NOUN
gs-4321	53	25	cells	cell	NOUN
gs-4321	53	26	shift	shift	VERB
gs-4321	53	27	between	between	ADP
gs-4321	53	28	quiescent	quiescent	ADJ
gs-4321	53	29	and	and	CCONJ
gs-4321	53	30	cycling	cycling	NOUN
gs-4321	53	31	states	state	NOUN
gs-4321	53	32	in	in	ADP
gs-4321	53	33	response	response	NOUN
gs-4321	53	34	to	to	ADP
gs-4321	53	35	chemotherapeutic	chemotherapeutic	ADJ
gs-4321	53	36	pressure	pressure	NOUN
gs-4321	53	37	(	(	PUNCT
gs-4321	53	38	tirosh	tirosh	NOUN
gs-4321	53	39	et	et	PROPN
gs-4321	53	40	al	al	PROPN
gs-4321	53	41	.	.	PROPN
gs-4321	53	42	,	,	PUNCT
gs-4321	53	43	2016	2016	NUM
gs-4321	53	44	;	;	PUNCT
gs-4321	53	45	wu	wu	PROPN
gs-4321	53	46	et	et	PROPN
gs-4321	53	47	al	al	PROPN
gs-4321	53	48	.	.	PROPN
gs-4321	53	49	,	,	PUNCT
gs-4321	53	50	2020	2020	NUM
gs-4321	53	51	)	)	PUNCT
gs-4321	53	52	.	.	PUNCT
gs-4321	54	1	such	such	ADJ
gs-4321	54	2	patterns	pattern	NOUN
gs-4321	54	3	emphasize	emphasize	VERB
gs-4321	54	4	the	the	DET
gs-4321	54	5	need	need	NOUN
gs-4321	54	6	for	for	ADP
gs-4321	54	7	analytical	analytical	ADJ
gs-4321	54	8	strategies	strategy	NOUN
gs-4321	54	9	capable	capable	ADJ
gs-4321	54	10	of	of	ADP
gs-4321	54	11	capturing	capture	VERB
gs-4321	54	12	reversible	reversible	ADJ
gs-4321	54	13	state	state	NOUN
gs-4321	54	14	dynamics	dynamic	NOUN
gs-4321	54	15	and	and	CCONJ
gs-4321	54	16	linking	link	VERB
gs-4321	54	17	them	they	PRON
gs-4321	54	18	to	to	ADP
gs-4321	54	19	regulatory	regulatory	ADJ
gs-4321	54	20	determinants	determinant	NOUN
gs-4321	54	21	.	.	PUNCT
gs-4321	55	1	another	another	DET
gs-4321	55	2	critical	critical	ADJ
gs-4321	55	3	advancement	advancement	NOUN
gs-4321	55	4	in	in	ADP
gs-4321	55	5	computational	computational	ADJ
gs-4321	55	6	single	single	ADJ
gs-4321	55	7	-	-	PUNCT
gs-4321	55	8	cell	cell	NOUN
gs-4321	55	9	biology	biology	NOUN
gs-4321	55	10	is	be	AUX
gs-4321	55	11	the	the	DET
gs-4321	55	12	development	development	NOUN
gs-4321	55	13	of	of	ADP
gs-4321	55	14	tools	tool	NOUN
gs-4321	55	15	for	for	ADP
gs-4321	55	16	multimodal	multimodal	NOUN
gs-4321	55	17	integration	integration	NOUN
gs-4321	55	18	.	.	PUNCT
gs-4321	56	1	techniques	technique	NOUN
gs-4321	56	2	such	such	ADJ
gs-4321	56	3	as	as	ADP
gs-4321	56	4	seurat	seurat	PROPN
gs-4321	56	5	v4	v4	PROPN
gs-4321	56	6	,	,	PUNCT
gs-4321	56	7	harmony	harmony	NOUN
gs-4321	56	8	,	,	PUNCT
gs-4321	56	9	and	and	CCONJ
gs-4321	56	10	mofa+	mofa+	AUX
gs-4321	56	11	allow	allow	VERB
gs-4321	56	12	for	for	ADP
gs-4321	56	13	the	the	DET
gs-4321	56	14	integration	integration	NOUN
gs-4321	56	15	of	of	ADP
gs-4321	56	16	transcriptomic	transcriptomic	ADJ
gs-4321	56	17	,	,	PUNCT
gs-4321	56	18	epigenomic	epigenomic	ADJ
gs-4321	56	19	,	,	PUNCT
gs-4321	56	20	proteomic	proteomic	NOUN
gs-4321	56	21	,	,	PUNCT
gs-4321	56	22	and	and	CCONJ
gs-4321	56	23	spatial	spatial	ADJ
gs-4321	56	24	datasets	dataset	NOUN
gs-4321	56	25	to	to	PART
gs-4321	56	26	generate	generate	VERB
gs-4321	56	27	unified	unified	ADJ
gs-4321	56	28	representations	representation	NOUN
gs-4321	56	29	of	of	ADP
gs-4321	56	30	cellular	cellular	ADJ
gs-4321	56	31	states	state	NOUN
gs-4321	56	32	(	(	PUNCT
gs-4321	56	33	stuart	stuart	PROPN
gs-4321	56	34	et	et	PROPN
gs-4321	56	35	al	al	PROPN
gs-4321	56	36	.	.	PROPN
gs-4321	56	37	,	,	PUNCT
gs-4321	56	38	2019	2019	NUM
gs-4321	56	39	;	;	PUNCT
gs-4321	56	40	argelaguet	argelaguet	PROPN
gs-4321	56	41	et	et	PROPN
gs-4321	56	42	al	al	PROPN
gs-4321	56	43	.	.	PROPN
gs-4321	56	44	,	,	PUNCT
gs-4321	56	45	2020	2020	NUM
gs-4321	56	46	)	)	PUNCT
gs-4321	56	47	.	.	PUNCT
gs-4321	57	1	these	these	DET
gs-4321	57	2	tools	tool	NOUN
gs-4321	57	3	are	be	AUX
gs-4321	57	4	essential	essential	ADJ
gs-4321	57	5	for	for	ADP
gs-4321	57	6	understanding	understand	VERB
gs-4321	57	7	plasticity	plasticity	NOUN
gs-4321	57	8	,	,	PUNCT
gs-4321	57	9	as	as	SCONJ
gs-4321	57	10	transitions	transition	NOUN
gs-4321	57	11	between	between	ADP
gs-4321	57	12	functional	functional	ADJ
gs-4321	57	13	states	state	NOUN
gs-4321	57	14	often	often	ADV
gs-4321	57	15	involve	involve	VERB
gs-4321	57	16	coordinated	coordinated	ADJ
gs-4321	57	17	changes	change	NOUN
gs-4321	57	18	across	across	ADP
gs-4321	57	19	multiple	multiple	ADJ
gs-4321	57	20	biological	biological	ADJ
gs-4321	57	21	layers	layer	NOUN
gs-4321	57	22	.	.	PUNCT
gs-4321	58	1	epigenetic	epigenetic	ADJ
gs-4321	58	2	remodeling	remodeling	NOUN
gs-4321	58	3	,	,	PUNCT
gs-4321	58	4	surface	surface	NOUN
gs-4321	58	5	receptor	receptor	NOUN
gs-4321	58	6	reconfiguration	reconfiguration	NOUN
gs-4321	58	7	,	,	PUNCT
gs-4321	58	8	metabolic	metabolic	NOUN
gs-4321	58	9	rewiring	rewiring	NOUN
gs-4321	58	10	,	,	PUNCT
gs-4321	58	11	and	and	CCONJ
gs-4321	58	12	transcriptional	transcriptional	ADJ
gs-4321	58	13	reprogramming	reprogramming	NOUN
gs-4321	58	14	must	must	AUX
gs-4321	58	15	be	be	AUX
gs-4321	58	16	analyzed	analyze	VERB
gs-4321	58	17	together	together	ADV
gs-4321	58	18	to	to	PART
gs-4321	58	19	obtain	obtain	VERB
gs-4321	58	20	an	an	DET
gs-4321	58	21	accurate	accurate	ADJ
gs-4321	58	22	picture	picture	NOUN
gs-4321	58	23	of	of	ADP
gs-4321	58	24	state	state	NOUN
gs-4321	58	25	interconversion	interconversion	NOUN
gs-4321	58	26	.	.	PUNCT
gs-4321	59	1	this	this	DET
gs-4321	59	2	integrative	integrative	ADJ
gs-4321	59	3	capacity	capacity	NOUN
gs-4321	59	4	also	also	ADV
gs-4321	59	5	enhances	enhance	VERB
gs-4321	59	6	the	the	DET
gs-4321	59	7	detection	detection	NOUN
gs-4321	59	8	of	of	ADP
gs-4321	59	9	subtle	subtle	ADJ
gs-4321	59	10	intermediate	intermediate	ADJ
gs-4321	59	11	states	state	NOUN
gs-4321	59	12	—	—	PUNCT
gs-4321	59	13	key	key	ADJ
gs-4321	59	14	intermediates	intermediate	NOUN
gs-4321	59	15	that	that	PRON
gs-4321	59	16	may	may	AUX
gs-4321	59	17	dictate	dictate	VERB
gs-4321	59	18	resistance	resistance	NOUN
gs-4321	59	19	or	or	CCONJ
gs-4321	59	20	metastatic	metastatic	ADJ
gs-4321	59	21	potential	potential	NOUN
gs-4321	59	22	.	.	PUNCT
gs-4321	60	1	beyond	beyond	ADP
gs-4321	60	2	intrinsic	intrinsic	ADJ
gs-4321	60	3	programs	program	NOUN
gs-4321	60	4	,	,	PUNCT
gs-4321	60	5	plasticity	plasticity	NOUN
gs-4321	60	6	is	be	AUX
gs-4321	60	7	shaped	shape	VERB
gs-4321	60	8	by	by	ADP
gs-4321	60	9	extrinsic	extrinsic	ADJ
gs-4321	60	10	influences	influence	NOUN
gs-4321	60	11	that	that	PRON
gs-4321	60	12	include	include	VERB
gs-4321	60	13	cytokines	cytokine	NOUN
gs-4321	60	14	,	,	PUNCT
gs-4321	60	15	extracellular	extracellular	ADJ
gs-4321	60	16	matrix	matrix	NOUN
gs-4321	60	17	components	component	NOUN
gs-4321	60	18	,	,	PUNCT
gs-4321	60	19	hypoxia	hypoxia	NOUN
gs-4321	60	20	,	,	PUNCT
gs-4321	60	21	and	and	CCONJ
gs-4321	60	22	metabolic	metabolic	NOUN
gs-4321	60	23	gradients	gradient	NOUN
gs-4321	60	24	.	.	PUNCT
gs-4321	61	1	spatial	spatial	ADJ
gs-4321	61	2	transcriptomic	transcriptomic	ADJ
gs-4321	61	3	technologies	technology	NOUN
gs-4321	61	4	,	,	PUNCT
gs-4321	61	5	including	include	VERB
gs-4321	61	6	10x	10x	PROPN
gs-4321	61	7	visium	visium	NOUN
gs-4321	61	8	,	,	PUNCT
gs-4321	61	9	slide	slide	NOUN
gs-4321	61	10	-	-	PUNCT
gs-4321	61	11	seq	seq	NOUN
gs-4321	61	12	,	,	PUNCT
gs-4321	61	13	and	and	CCONJ
gs-4321	61	14	merfish	merfish	PROPN
gs-4321	61	15	,	,	PUNCT
gs-4321	61	16	offer	offer	VERB
gs-4321	61	17	a	a	DET
gs-4321	61	18	means	mean	NOUN
gs-4321	61	19	to	to	PART
gs-4321	61	20	embed	embed	VERB
gs-4321	61	21	single	single	ADJ
gs-4321	61	22	-	-	PUNCT
gs-4321	61	23	cell	cell	NOUN
gs-4321	61	24	profiles	profile	NOUN
gs-4321	61	25	within	within	ADP
gs-4321	61	26	their	their	PRON
gs-4321	61	27	anatomical	anatomical	ADJ
gs-4321	61	28	context	context	NOUN
gs-4321	61	29	,	,	PUNCT
gs-4321	61	30	enabling	enable	VERB
gs-4321	61	31	direct	direct	ADJ
gs-4321	61	32	investigation	investigation	NOUN
gs-4321	61	33	of	of	ADP
gs-4321	61	34	how	how	SCONJ
gs-4321	61	35	niche	niche	NOUN
gs-4321	61	36	architecture	architecture	NOUN
gs-4321	61	37	affects	affect	VERB
gs-4321	61	38	cellular	cellular	ADJ
gs-4321	61	39	states	state	NOUN
gs-4321	61	40	(	(	PUNCT
gs-4321	61	41	zhang	zhang	X
gs-4321	61	42	et	et	PROPN
gs-4321	61	43	al	al	PROPN
gs-4321	61	44	.	.	PROPN
gs-4321	61	45	,	,	PUNCT
gs-4321	61	46	2021	2021	NUM
gs-4321	61	47	;	;	PUNCT
gs-4321	61	48	rodriques	rodrique	NOUN
gs-4321	61	49	et	et	PROPN
gs-4321	61	50	al	al	PROPN
gs-4321	61	51	.	.	PROPN
gs-4321	61	52	,	,	PUNCT
gs-4321	61	53	2019	2019	NUM
gs-4321	61	54	)	)	PUNCT
gs-4321	61	55	.	.	PUNCT
gs-4321	62	1	these	these	DET
gs-4321	62	2	spatially	spatially	ADV
gs-4321	62	3	resolved	resolve	VERB
gs-4321	62	4	analyses	analysis	NOUN
gs-4321	62	5	are	be	AUX
gs-4321	62	6	crucial	crucial	ADJ
gs-4321	62	7	for	for	ADP
gs-4321	62	8	determining	determine	VERB
gs-4321	62	9	whether	whether	SCONJ
gs-4321	62	10	stem	stem	VERB
gs-4321	62	11	-	-	PUNCT
gs-4321	62	12	like	like	ADJ
gs-4321	62	13	phenotypes	phenotype	NOUN
gs-4321	62	14	arise	arise	VERB
gs-4321	62	15	from	from	ADP
gs-4321	62	16	specific	specific	ADJ
gs-4321	62	17	microenvironmental	microenvironmental	ADJ
gs-4321	62	18	niches	niche	NOUN
gs-4321	62	19	or	or	CCONJ
gs-4321	62	20	whether	whether	SCONJ
gs-4321	62	21	they	they	PRON
gs-4321	62	22	emerge	emerge	VERB
gs-4321	62	23	independently	independently	ADV
gs-4321	62	24	of	of	ADP
gs-4321	62	25	spatial	spatial	ADJ
gs-4321	62	26	constraints	constraint	NOUN
gs-4321	62	27	.	.	PUNCT
gs-4321	63	1	furthermore	furthermore	ADV
gs-4321	63	2	,	,	PUNCT
gs-4321	63	3	spatial	spatial	ADJ
gs-4321	63	4	analyses	analysis	NOUN
gs-4321	63	5	facilitate	facilitate	VERB
gs-4321	63	6	the	the	DET
gs-4321	63	7	identification	identification	NOUN
gs-4321	63	8	of	of	ADP
gs-4321	63	9	supportive	supportive	ADJ
gs-4321	63	10	stromal	stromal	ADJ
gs-4321	63	11	populations	population	NOUN
gs-4321	63	12	and	and	CCONJ
gs-4321	63	13	communication	communication	NOUN
gs-4321	63	14	hubs	hub	NOUN
gs-4321	63	15	that	that	PRON
gs-4321	63	16	influence	influence	VERB
gs-4321	63	17	malignant	malignant	ADJ
gs-4321	63	18	cell	cell	NOUN
gs-4321	63	19	behavior	behavior	NOUN
gs-4321	63	20	.	.	PUNCT
gs-4321	64	1	background	background	NOUN
gs-4321	64	2	the	the	DET
gs-4321	64	3	historical	historical	ADJ
gs-4321	64	4	understanding	understanding	NOUN
gs-4321	64	5	of	of	ADP
gs-4321	64	6	cancer	cancer	NOUN
gs-4321	64	7	as	as	ADP
gs-4321	64	8	a	a	DET
gs-4321	64	9	homogeneous	homogeneous	ADJ
gs-4321	64	10	mass	mass	NOUN
gs-4321	64	11	of	of	ADP
gs-4321	64	12	rapidly	rapidly	ADV
gs-4321	64	13	dividing	divide	VERB
gs-4321	64	14	cells	cell	NOUN
gs-4321	64	15	has	have	AUX
gs-4321	64	16	been	be	AUX
gs-4321	64	17	fundamentally	fundamentally	ADV
gs-4321	64	18	overturned	overturn	VERB
gs-4321	64	19	.	.	PUNCT
gs-4321	65	1	modern	modern	ADJ
gs-4321	65	2	oncology	oncology	NOUN
gs-4321	65	3	now	now	ADV
gs-4321	65	4	recognizes	recognize	VERB
gs-4321	65	5	tumors	tumor	NOUN
gs-4321	65	6	not	not	PART
gs-4321	65	7	as	as	ADP
gs-4321	65	8	static	static	ADJ
gs-4321	65	9	entities	entity	NOUN
gs-4321	65	10	,	,	PUNCT
gs-4321	65	11	but	but	CCONJ
gs-4321	65	12	as	as	ADP
gs-4321	65	13	complex	complex	ADJ
gs-4321	65	14	,	,	PUNCT
gs-4321	65	15	dynamic	dynamic	ADJ
gs-4321	65	16	ecosystems	ecosystem	NOUN
gs-4321	65	17	,	,	PUNCT
gs-4321	65	18	often	often	ADV
gs-4321	65	19	termed	term	VERB
gs-4321	65	20	the	the	DET
gs-4321	65	21	"	"	PUNCT
gs-4321	65	22	tumor	tumor	NOUN
gs-4321	65	23	microenvironment	microenvironment	NOUN
gs-4321	65	24	"	"	PUNCT
gs-4321	65	25	(	(	PUNCT
gs-4321	65	26	tme	tme	NOUN
gs-4321	65	27	)	)	PUNCT
gs-4321	65	28	.	.	PUNCT
gs-4321	66	1	this	this	DET
gs-4321	66	2	ecosystem	ecosystem	NOUN
gs-4321	66	3	is	be	AUX
gs-4321	66	4	composed	compose	VERB
gs-4321	66	5	of	of	ADP
gs-4321	66	6	a	a	DET
gs-4321	66	7	diverse	diverse	ADJ
gs-4321	66	8	array	array	NOUN
gs-4321	66	9	of	of	ADP
gs-4321	66	10	cell	cell	NOUN
gs-4321	66	11	types	type	NOUN
gs-4321	66	12	,	,	PUNCT
gs-4321	66	13	including	include	VERB
gs-4321	66	14	malignant	malignant	ADJ
gs-4321	66	15	cells	cell	NOUN
gs-4321	66	16	,	,	PUNCT
gs-4321	66	17	cancer	cancer	NOUN
gs-4321	66	18	-	-	PUNCT
gs-4321	66	19	associated	associate	VERB
gs-4321	66	20	fibroblasts	fibroblast	NOUN
gs-4321	66	21	(	(	PUNCT
gs-4321	66	22	cafs	cafs	NOUN
gs-4321	66	23	)	)	PUNCT
gs-4321	66	24	,	,	PUNCT
gs-4321	66	25	immune	immune	ADJ
gs-4321	66	26	cells	cell	NOUN
gs-4321	66	27	(	(	PUNCT
gs-4321	66	28	e.g.	e.g.	ADV
gs-4321	66	29	,	,	PUNCT
gs-4321	66	30	t	t	NOUN
gs-4321	66	31	cells	cell	NOUN
gs-4321	66	32	,	,	PUNCT
gs-4321	66	33	macrophages	macrophage	NOUN
gs-4321	66	34	)	)	PUNCT
gs-4321	66	35	,	,	PUNCT
gs-4321	66	36	georgian	georgian	NOUN
gs-4321	66	37	scientists/	scientists/	NUM
gs-4321	66	38	.	.	PUNCT
gs-4321	67	1	7	7	NUM
gs-4321	67	2	n	n	DET
gs-4321	67	3	4	4	NUM
gs-4321	67	4	,	,	PUNCT
gs-4321	67	5	2025	2025	NUM
gs-4321	67	6	338	338	NUM
gs-4321	67	7	endothelial	endothelial	ADJ
gs-4321	67	8	cells	cell	NOUN
gs-4321	67	9	,	,	PUNCT
gs-4321	67	10	and	and	CCONJ
gs-4321	67	11	a	a	DET
gs-4321	67	12	variety	variety	NOUN
gs-4321	67	13	of	of	ADP
gs-4321	67	14	extracellular	extracellular	ADJ
gs-4321	67	15	components	component	NOUN
gs-4321	67	16	.	.	PUNCT
gs-4321	68	1	within	within	ADP
gs-4321	68	2	this	this	DET
gs-4321	68	3	milieu	milieu	NOUN
gs-4321	68	4	,	,	PUNCT
gs-4321	68	5	the	the	DET
gs-4321	68	6	concept	concept	NOUN
gs-4321	68	7	of	of	ADP
gs-4321	68	8	cellular	cellular	ADJ
gs-4321	68	9	heterogeneity	heterogeneity	NOUN
gs-4321	68	10	—	—	PUNCT
gs-4321	68	11	the	the	DET
gs-4321	68	12	existence	existence	NOUN
gs-4321	68	13	of	of	ADP
gs-4321	68	14	distinct	distinct	ADJ
gs-4321	68	15	subpopulations	subpopulation	NOUN
gs-4321	68	16	of	of	ADP
gs-4321	68	17	cancer	cancer	NOUN
gs-4321	68	18	cells	cell	NOUN
gs-4321	68	19	with	with	ADP
gs-4321	68	20	different	different	ADJ
gs-4321	68	21	functional	functional	ADJ
gs-4321	68	22	properties	property	NOUN
gs-4321	68	23	—	—	PUNCT
gs-4321	68	24	has	have	AUX
gs-4321	68	25	emerged	emerge	VERB
gs-4321	68	26	as	as	ADP
gs-4321	68	27	a	a	DET
gs-4321	68	28	central	central	ADJ
gs-4321	68	29	pillar	pillar	NOUN
gs-4321	68	30	of	of	ADP
gs-4321	68	31	cancer	cancer	NOUN
gs-4321	68	32	biology	biology	NOUN
gs-4321	68	33	.	.	PUNCT
gs-4321	69	1	among	among	ADP
gs-4321	69	2	these	these	DET
gs-4321	69	3	subpopulations	subpopulation	NOUN
gs-4321	69	4	,	,	PUNCT
gs-4321	69	5	none	none	NOUN
gs-4321	69	6	has	have	AUX
gs-4321	69	7	proven	prove	VERB
gs-4321	69	8	more	more	ADV
gs-4321	69	9	critical	critical	ADJ
gs-4321	69	10	,	,	PUNCT
gs-4321	69	11	or	or	CCONJ
gs-4321	69	12	more	more	ADV
gs-4321	69	13	elusive	elusive	ADJ
gs-4321	69	14	,	,	PUNCT
gs-4321	69	15	than	than	ADP
gs-4321	69	16	cancer	cancer	NOUN
gs-4321	69	17	stem	stem	NOUN
gs-4321	69	18	cells	cell	NOUN
gs-4321	69	19	(	(	PUNCT
gs-4321	69	20	cscs	cscs	PROPN
gs-4321	69	21	)	)	PUNCT
gs-4321	69	22	.	.	PUNCT
gs-4321	70	1	cscs	cscs	PROPN
gs-4321	70	2	are	be	AUX
gs-4321	70	3	a	a	DET
gs-4321	70	4	minority	minority	NOUN
gs-4321	70	5	population	population	NOUN
gs-4321	70	6	within	within	ADP
gs-4321	70	7	a	a	DET
gs-4321	70	8	tumor	tumor	NOUN
gs-4321	70	9	that	that	PRON
gs-4321	70	10	possess	possess	VERB
gs-4321	70	11	the	the	DET
gs-4321	70	12	dual	dual	ADJ
gs-4321	70	13	capacities	capacity	NOUN
gs-4321	70	14	of	of	ADP
gs-4321	70	15	selfrenewal	selfrenewal	NOUN
gs-4321	70	16	and	and	CCONJ
gs-4321	70	17	differentiation	differentiation	NOUN
gs-4321	70	18	,	,	PUNCT
gs-4321	70	19	mirroring	mirror	VERB
gs-4321	70	20	the	the	DET
gs-4321	70	21	behavior	behavior	NOUN
gs-4321	70	22	of	of	ADP
gs-4321	70	23	normal	normal	ADJ
gs-4321	70	24	stem	stem	NOUN
gs-4321	70	25	cells	cell	NOUN
gs-4321	70	26	.	.	PUNCT
gs-4321	71	1	initially	initially	ADV
gs-4321	71	2	conceptualized	conceptualize	VERB
gs-4321	71	3	within	within	ADP
gs-4321	71	4	a	a	DET
gs-4321	71	5	rigid	rigid	ADJ
gs-4321	71	6	hierarchical	hierarchical	ADJ
gs-4321	71	7	model	model	NOUN
gs-4321	71	8	,	,	PUNCT
gs-4321	71	9	it	it	PRON
gs-4321	71	10	was	be	AUX
gs-4321	71	11	believed	believe	VERB
gs-4321	71	12	that	that	SCONJ
gs-4321	71	13	a	a	DET
gs-4321	71	14	fixed	fix	VERB
gs-4321	71	15	,	,	PUNCT
gs-4321	71	16	small	small	ADJ
gs-4321	71	17	pool	pool	NOUN
gs-4321	71	18	of	of	ADP
gs-4321	71	19	cscs	cscs	PROPN
gs-4321	71	20	sat	sit	VERB
gs-4321	71	21	at	at	ADP
gs-4321	71	22	the	the	DET
gs-4321	71	23	apex	apex	NOUN
gs-4321	71	24	of	of	ADP
gs-4321	71	25	a	a	DET
gs-4321	71	26	unidirectional	unidirectional	ADJ
gs-4321	71	27	lineage	lineage	NOUN
gs-4321	71	28	tree	tree	NOUN
gs-4321	71	29	,	,	PUNCT
gs-4321	71	30	giving	give	VERB
gs-4321	71	31	rise	rise	NOUN
gs-4321	71	32	to	to	ADP
gs-4321	71	33	all	all	DET
gs-4321	71	34	other	other	ADJ
gs-4321	71	35	,	,	PUNCT
gs-4321	71	36	more	more	ADV
gs-4321	71	37	differentiated	differentiated	ADJ
gs-4321	71	38	,	,	PUNCT
gs-4321	71	39	cancer	cancer	NOUN
gs-4321	71	40	cells	cell	NOUN
gs-4321	71	41	that	that	PRON
gs-4321	71	42	constituted	constitute	VERB
gs-4321	71	43	the	the	DET
gs-4321	71	44	tumor	tumor	NOUN
gs-4321	71	45	bulk	bulk	NOUN
gs-4321	71	46	.	.	PUNCT
gs-4321	72	1	this	this	DET
gs-4321	72	2	model	model	NOUN
gs-4321	72	3	explained	explain	VERB
gs-4321	72	4	observed	observed	ADJ
gs-4321	72	5	phenomena	phenomenon	NOUN
gs-4321	72	6	like	like	ADP
gs-4321	72	7	therapeutic	therapeutic	ADJ
gs-4321	72	8	resistance	resistance	NOUN
gs-4321	72	9	and	and	CCONJ
gs-4321	72	10	relapse	relapse	NOUN
gs-4321	72	11	,	,	PUNCT
gs-4321	72	12	as	as	SCONJ
gs-4321	72	13	conventional	conventional	ADJ
gs-4321	72	14	therapies	therapy	NOUN
gs-4321	72	15	might	might	AUX
gs-4321	72	16	kill	kill	VERB
gs-4321	72	17	the	the	DET
gs-4321	72	18	bulk	bulk	ADJ
gs-4321	72	19	differentiated	differentiate	VERB
gs-4321	72	20	cells	cell	NOUN
gs-4321	72	21	but	but	CCONJ
gs-4321	72	22	spare	spare	VERB
gs-4321	72	23	the	the	DET
gs-4321	72	24	resilient	resilient	ADJ
gs-4321	72	25	cscs	csc	NOUN
gs-4321	72	26	.	.	PUNCT
gs-4321	73	1	however	however	ADV
gs-4321	73	2	,	,	PUNCT
gs-4321	73	3	a	a	DET
gs-4321	73	4	more	more	ADV
gs-4321	73	5	nuanced	nuanced	ADJ
gs-4321	73	6	and	and	CCONJ
gs-4321	73	7	powerful	powerful	ADJ
gs-4321	73	8	concept	concept	NOUN
gs-4321	73	9	has	have	AUX
gs-4321	73	10	since	since	SCONJ
gs-4321	73	11	supplanted	supplant	VERB
gs-4321	73	12	this	this	DET
gs-4321	73	13	rigid	rigid	ADJ
gs-4321	73	14	hierarchy	hierarchy	NOUN
gs-4321	73	15	:	:	PUNCT
gs-4321	73	16	cancer	cancer	NOUN
gs-4321	73	17	cell	cell	NOUN
gs-4321	73	18	plasticity	plasticity	NOUN
gs-4321	73	19	.	.	PUNCT
gs-4321	74	1	plasticity	plasticity	NOUN
gs-4321	74	2	refers	refer	VERB
gs-4321	74	3	to	to	ADP
gs-4321	74	4	the	the	DET
gs-4321	74	5	remarkable	remarkable	ADJ
gs-4321	74	6	ability	ability	NOUN
gs-4321	74	7	of	of	ADP
gs-4321	74	8	cancer	cancer	NOUN
gs-4321	74	9	cells	cell	NOUN
gs-4321	74	10	to	to	PART
gs-4321	74	11	dynamically	dynamically	VERB
gs-4321	74	12	transition	transition	NOUN
gs-4321	74	13	between	between	ADP
gs-4321	74	14	different	different	ADJ
gs-4321	74	15	phenotypic	phenotypic	ADJ
gs-4321	74	16	states	state	NOUN
gs-4321	74	17	.	.	PUNCT
gs-4321	75	1	a	a	DET
gs-4321	75	2	differentiated	differentiated	ADJ
gs-4321	75	3	cancer	cancer	NOUN
gs-4321	75	4	cell	cell	NOUN
gs-4321	75	5	can	can	AUX
gs-4321	75	6	,	,	PUNCT
gs-4321	75	7	in	in	ADP
gs-4321	75	8	response	response	NOUN
gs-4321	75	9	to	to	ADP
gs-4321	75	10	environmental	environmental	ADJ
gs-4321	75	11	pressures	pressure	NOUN
gs-4321	75	12	such	such	ADJ
gs-4321	75	13	as	as	ADP
gs-4321	75	14	chemotherapy	chemotherapy	NOUN
gs-4321	75	15	,	,	PUNCT
gs-4321	75	16	radiation	radiation	NOUN
gs-4321	75	17	,	,	PUNCT
gs-4321	75	18	or	or	CCONJ
gs-4321	75	19	immune	immune	ADJ
gs-4321	75	20	attack	attack	NOUN
gs-4321	75	21	,	,	PUNCT
gs-4321	75	22	"	"	PUNCT
gs-4321	75	23	de	de	X
gs-4321	75	24	-	-	NOUN
gs-4321	75	25	differentiate	differentiate	ADJ
gs-4321	75	26	"	"	PUNCT
gs-4321	75	27	or	or	CCONJ
gs-4321	75	28	reprogram	reprogram	VERB
gs-4321	75	29	itself	itself	PRON
gs-4321	75	30	to	to	PART
gs-4321	75	31	re	re	VERB
gs-4321	75	32	-	-	VERB
gs-4321	75	33	acquire	acquire	VERB
gs-4321	75	34	stem	stem	NOUN
gs-4321	75	35	-	-	PUNCT
gs-4321	75	36	like	like	ADJ
gs-4321	75	37	properties	property	NOUN
gs-4321	75	38	.	.	PUNCT
gs-4321	76	1	conversely	conversely	ADV
gs-4321	76	2	,	,	PUNCT
gs-4321	76	3	cscs	cscs	PROPN
gs-4321	76	4	can	can	AUX
gs-4321	76	5	differentiate	differentiate	VERB
gs-4321	76	6	into	into	ADP
gs-4321	76	7	various	various	ADJ
gs-4321	76	8	cell	cell	NOUN
gs-4321	76	9	types	type	NOUN
gs-4321	76	10	.	.	PUNCT
gs-4321	77	1	this	this	DET
gs-4321	77	2	fluidity	fluidity	NOUN
gs-4321	77	3	means	mean	VERB
gs-4321	77	4	that	that	SCONJ
gs-4321	77	5	the	the	DET
gs-4321	77	6	csc	csc	PROPN
gs-4321	77	7	pool	pool	NOUN
gs-4321	77	8	is	be	AUX
gs-4321	77	9	not	not	PART
gs-4321	77	10	fixed	fix	VERB
gs-4321	77	11	;	;	PUNCT
gs-4321	77	12	it	it	PRON
gs-4321	77	13	can	can	AUX
gs-4321	77	14	be	be	AUX
gs-4321	77	15	replenished	replenish	VERB
gs-4321	77	16	from	from	ADP
gs-4321	77	17	non	non	ADJ
gs-4321	77	18	-	-	ADJ
gs-4321	77	19	stem	stem	ADJ
gs-4321	77	20	populations	population	NOUN
gs-4321	77	21	,	,	PUNCT
gs-4321	77	22	making	make	VERB
gs-4321	77	23	it	it	PRON
gs-4321	77	24	a	a	DET
gs-4321	77	25	moving	move	VERB
gs-4321	77	26	target	target	NOUN
gs-4321	77	27	for	for	ADP
gs-4321	77	28	therapy	therapy	NOUN
gs-4321	77	29	.	.	PUNCT
gs-4321	78	1	this	this	DET
gs-4321	78	2	plasticity	plasticity	NOUN
gs-4321	78	3	is	be	AUX
gs-4321	78	4	increasingly	increasingly	ADV
gs-4321	78	5	identified	identify	VERB
gs-4321	78	6	as	as	ADP
gs-4321	78	7	a	a	DET
gs-4321	78	8	fundamental	fundamental	ADJ
gs-4321	78	9	driver	driver	NOUN
gs-4321	78	10	of	of	ADP
gs-4321	78	11	tumor	tumor	NOUN
gs-4321	78	12	initiation	initiation	NOUN
gs-4321	78	13	,	,	PUNCT
gs-4321	78	14	progression	progression	NOUN
gs-4321	78	15	,	,	PUNCT
gs-4321	78	16	metastatic	metastatic	ADJ
gs-4321	78	17	dissemination	dissemination	NOUN
gs-4321	78	18	,	,	PUNCT
gs-4321	78	19	and	and	CCONJ
gs-4321	78	20	,	,	PUNCT
gs-4321	78	21	most	most	ADV
gs-4321	78	22	critically	critically	ADV
gs-4321	78	23	,	,	PUNCT
gs-4321	78	24	therapeutic	therapeutic	ADJ
gs-4321	78	25	failure	failure	NOUN
gs-4321	78	26	.	.	PUNCT
gs-4321	79	1	even	even	ADV
gs-4321	79	2	after	after	ADP
gs-4321	79	3	successful	successful	ADJ
gs-4321	79	4	initial	initial	ADJ
gs-4321	79	5	treatment	treatment	NOUN
gs-4321	79	6	,	,	PUNCT
gs-4321	79	7	plastic	plastic	NOUN
gs-4321	79	8	cells	cell	NOUN
gs-4321	79	9	can	can	AUX
gs-4321	79	10	survive	survive	VERB
gs-4321	79	11	,	,	PUNCT
gs-4321	79	12	adapt	adapt	VERB
gs-4321	79	13	,	,	PUNCT
gs-4321	79	14	and	and	CCONJ
gs-4321	79	15	ultimately	ultimately	ADV
gs-4321	79	16	drive	drive	VERB
gs-4321	79	17	disease	disease	NOUN
gs-4321	79	18	recurrence	recurrence	NOUN
gs-4321	79	19	.	.	PUNCT
gs-4321	80	1	the	the	DET
gs-4321	80	2	molecular	molecular	ADJ
gs-4321	80	3	mechanisms	mechanism	NOUN
gs-4321	80	4	underpinning	underpin	VERB
gs-4321	80	5	this	this	DET
gs-4321	80	6	plasticity	plasticity	NOUN
gs-4321	80	7	are	be	AUX
gs-4321	80	8	multilayered	multilayere	VERB
gs-4321	80	9	and	and	CCONJ
gs-4321	80	10	interconnected	interconnected	ADJ
gs-4321	80	11	.	.	PUNCT
gs-4321	81	1	at	at	ADP
gs-4321	81	2	the	the	DET
gs-4321	81	3	transcriptional	transcriptional	ADJ
gs-4321	81	4	level	level	NOUN
gs-4321	81	5	,	,	PUNCT
gs-4321	81	6	core	core	NOUN
gs-4321	81	7	pluripotency	pluripotency	NOUN
gs-4321	81	8	factors	factor	NOUN
gs-4321	81	9	such	such	ADJ
gs-4321	81	10	as	as	ADP
gs-4321	81	11	sox2	sox2	NOUN
gs-4321	81	12	,	,	PUNCT
gs-4321	81	13	nanog	nanog	PROPN
gs-4321	81	14	,	,	PUNCT
gs-4321	81	15	and	and	CCONJ
gs-4321	81	16	oct4	oct4	PROPN
gs-4321	81	17	,	,	PUNCT
gs-4321	81	18	along	along	ADP
gs-4321	81	19	with	with	ADP
gs-4321	81	20	epithelial	epithelial	ADJ
gs-4321	81	21	-	-	PUNCT
gs-4321	81	22	mesenchymal	mesenchymal	NOUN
gs-4321	81	23	transition	transition	NOUN
gs-4321	81	24	(	(	PUNCT
gs-4321	81	25	emt	emt	NOUN
gs-4321	81	26	)	)	PUNCT
gs-4321	81	27	regulators	regulator	NOUN
gs-4321	81	28	like	like	ADP
gs-4321	81	29	zeb1	zeb1	PROPN
gs-4321	81	30	and	and	CCONJ
gs-4321	81	31	snail	snail	NOUN
gs-4321	81	32	,	,	PUNCT
gs-4321	81	33	are	be	AUX
gs-4321	81	34	reactivated	reactivate	VERB
gs-4321	81	35	to	to	PART
gs-4321	81	36	enable	enable	VERB
gs-4321	81	37	reprogramming	reprogramme	VERB
gs-4321	81	38	.	.	PUNCT
gs-4321	82	1	epigenetically	epigenetically	ADV
gs-4321	82	2	,	,	PUNCT
gs-4321	82	3	chromatin	chromatin	NOUN
gs-4321	82	4	remodeling	remodeling	NOUN
gs-4321	82	5	complexes	complex	NOUN
gs-4321	82	6	and	and	CCONJ
gs-4321	82	7	modification	modification	NOUN
gs-4321	82	8	enzymes	enzyme	NOUN
gs-4321	82	9	dynamically	dynamically	ADV
gs-4321	82	10	alter	alter	VERB
gs-4321	82	11	the	the	DET
gs-4321	82	12	accessibility	accessibility	NOUN
gs-4321	82	13	of	of	ADP
gs-4321	82	14	the	the	DET
gs-4321	82	15	genome	genome	NOUN
gs-4321	82	16	,	,	PUNCT
gs-4321	82	17	creating	create	VERB
gs-4321	82	18	a	a	DET
gs-4321	82	19	permissive	permissive	ADJ
gs-4321	82	20	landscape	landscape	NOUN
gs-4321	82	21	for	for	ADP
gs-4321	82	22	these	these	DET
gs-4321	82	23	transcriptional	transcriptional	ADJ
gs-4321	82	24	shifts	shift	NOUN
gs-4321	82	25	.	.	PUNCT
gs-4321	83	1	stress	stress	NOUN
gs-4321	83	2	-	-	PUNCT
gs-4321	83	3	responsive	responsive	ADJ
gs-4321	83	4	pathways	pathway	NOUN
gs-4321	83	5	,	,	PUNCT
gs-4321	83	6	such	such	ADJ
gs-4321	83	7	as	as	ADP
gs-4321	83	8	those	those	PRON
gs-4321	83	9	involving	involve	VERB
gs-4321	83	10	ap-1	ap-1	ADP
gs-4321	83	11	,	,	PUNCT
gs-4321	83	12	stat3	stat3	NOUN
gs-4321	83	13	,	,	PUNCT
gs-4321	83	14	and	and	CCONJ
gs-4321	83	15	nfb	nfb	NOUN
gs-4321	83	16	,	,	PUNCT
gs-4321	83	17	are	be	AUX
gs-4321	83	18	activated	activate	VERB
gs-4321	83	19	by	by	ADP
gs-4321	83	20	therapy	therapy	NOUN
gs-4321	83	21	,	,	PUNCT
gs-4321	83	22	further	far	ADV
gs-4321	83	23	promoting	promote	VERB
gs-4321	83	24	a	a	DET
gs-4321	83	25	plastic	plastic	ADJ
gs-4321	83	26	and	and	CCONJ
gs-4321	83	27	resilient	resilient	ADJ
gs-4321	83	28	state	state	NOUN
gs-4321	83	29	.	.	PUNCT
gs-4321	84	1	metabolically	metabolically	NOUN
gs-4321	84	2	,	,	PUNCT
gs-4321	84	3	cells	cell	NOUN
gs-4321	84	4	rewire	rewire	VERB
gs-4321	84	5	their	their	PRON
gs-4321	84	6	energy	energy	NOUN
gs-4321	84	7	production	production	NOUN
gs-4321	84	8	,	,	PUNCT
gs-4321	84	9	often	often	ADV
gs-4321	84	10	enhancing	enhance	VERB
gs-4321	84	11	glycolysis	glycolysis	NOUN
gs-4321	84	12	,	,	PUNCT
gs-4321	84	13	antioxidant	antioxidant	ADJ
gs-4321	84	14	defenses	defense	NOUN
gs-4321	84	15	,	,	PUNCT
gs-4321	84	16	and	and	CCONJ
gs-4321	84	17	lipid	lipid	NOUN
gs-4321	84	18	metabolism	metabolism	NOUN
gs-4321	84	19	to	to	PART
gs-4321	84	20	survive	survive	VERB
gs-4321	84	21	the	the	DET
gs-4321	84	22	harsh	harsh	ADJ
gs-4321	84	23	conditions	condition	NOUN
gs-4321	84	24	of	of	ADP
gs-4321	84	25	treatment	treatment	NOUN
gs-4321	84	26	.	.	PUNCT
gs-4321	85	1	these	these	DET
gs-4321	85	2	intrinsic	intrinsic	ADJ
gs-4321	85	3	programs	program	NOUN
gs-4321	85	4	do	do	AUX
gs-4321	85	5	not	not	PART
gs-4321	85	6	operate	operate	VERB
gs-4321	85	7	in	in	ADP
gs-4321	85	8	isolation	isolation	NOUN
gs-4321	85	9	;	;	PUNCT
gs-4321	85	10	they	they	PRON
gs-4321	85	11	are	be	AUX
gs-4321	85	12	profoundly	profoundly	ADV
gs-4321	85	13	shaped	shape	VERB
gs-4321	85	14	by	by	ADP
gs-4321	85	15	the	the	DET
gs-4321	85	16	extrinsic	extrinsic	ADJ
gs-4321	85	17	signals	signal	NOUN
gs-4321	85	18	from	from	ADP
gs-4321	85	19	the	the	DET
gs-4321	85	20	tme	tme	NOUN
gs-4321	85	21	.	.	PUNCT
gs-4321	86	1	the	the	DET
gs-4321	86	2	tumor	tumor	NOUN
gs-4321	86	3	microenvironment	microenvironment	NOUN
gs-4321	86	4	acts	act	VERB
gs-4321	86	5	as	as	ADP
gs-4321	86	6	both	both	CCONJ
gs-4321	86	7	a	a	DET
gs-4321	86	8	cradle	cradle	NOUN
gs-4321	86	9	and	and	CCONJ
gs-4321	86	10	a	a	DET
gs-4321	86	11	crucible	crucible	NOUN
gs-4321	86	12	for	for	ADP
gs-4321	86	13	plasticity	plasticity	NOUN
gs-4321	86	14	.	.	PUNCT
gs-4321	87	1	cancerassociated	cancerassociate	VERB
gs-4321	87	2	fibroblasts	fibroblast	NOUN
gs-4321	87	3	(	(	PUNCT
gs-4321	87	4	cafs	cafs	NOUN
gs-4321	87	5	)	)	PUNCT
gs-4321	87	6	secrete	secrete	NOUN
gs-4321	87	7	a	a	DET
gs-4321	87	8	plethora	plethora	NOUN
gs-4321	87	9	of	of	ADP
gs-4321	87	10	factors	factor	NOUN
gs-4321	87	11	,	,	PUNCT
gs-4321	87	12	including	include	VERB
gs-4321	87	13	tgf	tgf	PROPN
gs-4321	87	14	,	,	PUNCT
gs-4321	87	15	which	which	PRON
gs-4321	87	16	drives	drive	VERB
gs-4321	87	17	emt	emt	PROPN
gs-4321	87	18	and	and	CCONJ
gs-4321	87	19	stemness	stemness	NOUN
gs-4321	87	20	,	,	PUNCT
gs-4321	87	21	and	and	CCONJ
gs-4321	87	22	hgf	hgf	NOUN
gs-4321	87	23	,	,	PUNCT
gs-4321	87	24	which	which	PRON
gs-4321	87	25	promotes	promote	VERB
gs-4321	87	26	survival	survival	NOUN
gs-4321	87	27	and	and	CCONJ
gs-4321	87	28	motility	motility	NOUN
gs-4321	87	29	.	.	PUNCT
gs-4321	88	1	tumor	tumor	NOUN
gs-4321	88	2	-	-	PUNCT
gs-4321	88	3	associated	associate	VERB
gs-4321	88	4	macrophages	macrophage	NOUN
gs-4321	88	5	(	(	PUNCT
gs-4321	88	6	tams	tam	NOUN
gs-4321	88	7	)	)	PUNCT
gs-4321	88	8	are	be	AUX
gs-4321	88	9	a	a	DET
gs-4321	88	10	potent	potent	ADJ
gs-4321	88	11	source	source	NOUN
gs-4321	88	12	of	of	ADP
gs-4321	88	13	il-6	il-6	NUM
gs-4321	88	14	and	and	CCONJ
gs-4321	88	15	other	other	ADJ
gs-4321	88	16	inflammatory	inflammatory	ADJ
gs-4321	88	17	cytokines	cytokine	NOUN
gs-4321	88	18	that	that	PRON
gs-4321	88	19	activate	activate	VERB
gs-4321	88	20	stat3	stat3	NOUN
gs-4321	88	21	signaling	signal	VERB
gs-4321	88	22	,	,	PUNCT
gs-4321	88	23	reinforcing	reinforce	VERB
gs-4321	88	24	stem	stem	NOUN
gs-4321	88	25	-	-	PUNCT
gs-4321	88	26	like	like	ADJ
gs-4321	88	27	and	and	CCONJ
gs-4321	88	28	therapy	therapy	NOUN
gs-4321	88	29	-	-	PUNCT
gs-4321	88	30	tolerant	tolerant	ADJ
gs-4321	88	31	programs	program	NOUN
gs-4321	88	32	.	.	PUNCT
gs-4321	89	1	endothelial	endothelial	ADJ
gs-4321	89	2	cells	cell	NOUN
gs-4321	89	3	in	in	ADP
gs-4321	89	4	perivascular	perivascular	ADJ
gs-4321	89	5	niches	niche	NOUN
gs-4321	89	6	provide	provide	VERB
gs-4321	89	7	notch	notch	ADJ
gs-4321	89	8	ligands	ligand	NOUN
gs-4321	89	9	and	and	CCONJ
gs-4321	89	10	cxcl12	cxcl12	ADJ
gs-4321	89	11	,	,	PUNCT
gs-4321	89	12	which	which	PRON
gs-4321	89	13	help	help	VERB
gs-4321	89	14	maintain	maintain	VERB
gs-4321	89	15	cscs	cscs	PROPN
gs-4321	89	16	in	in	ADP
gs-4321	89	17	a	a	DET
gs-4321	89	18	quiescent	quiescent	ADJ
gs-4321	89	19	,	,	PUNCT
gs-4321	89	20	protected	protect	VERB
gs-4321	89	21	state	state	NOUN
gs-4321	89	22	.	.	PUNCT
gs-4321	90	1	perhaps	perhaps	ADV
gs-4321	90	2	one	one	NUM
gs-4321	90	3	of	of	ADP
gs-4321	90	4	the	the	DET
gs-4321	90	5	most	most	ADV
gs-4321	90	6	intriguing	intriguing	ADJ
gs-4321	90	7	mechanisms	mechanism	NOUN
gs-4321	90	8	of	of	ADP
gs-4321	90	9	georgian	georgian	NOUN
gs-4321	90	10	scientists/	scientists/	NUM
gs-4321	90	11	.	.	PUNCT
gs-4321	91	1	7	7	NUM
gs-4321	91	2	n	n	DET
gs-4321	91	3	4	4	NUM
gs-4321	91	4	,	,	PUNCT
gs-4321	91	5	2025	2025	NUM
gs-4321	91	6	339	339	NUM
gs-4321	91	7	intercellular	intercellular	ADJ
gs-4321	91	8	communication	communication	NOUN
gs-4321	91	9	is	be	AUX
gs-4321	91	10	mediated	mediate	VERB
gs-4321	91	11	by	by	ADP
gs-4321	91	12	exosomes	exosome	NOUN
gs-4321	91	13	and	and	CCONJ
gs-4321	91	14	other	other	ADJ
gs-4321	91	15	extracellular	extracellular	ADJ
gs-4321	91	16	vesicles	vesicle	NOUN
gs-4321	91	17	.	.	PUNCT
gs-4321	92	1	these	these	DET
gs-4321	92	2	nano	nano	NOUN
gs-4321	92	3	-	-	PUNCT
gs-4321	92	4	sized	sized	ADJ
gs-4321	92	5	vesicles	vesicle	NOUN
gs-4321	92	6	act	act	VERB
gs-4321	92	7	as	as	ADP
gs-4321	92	8	molecular	molecular	ADJ
gs-4321	92	9	cargo	cargo	NOUN
gs-4321	92	10	ships	ship	NOUN
gs-4321	92	11	,	,	PUNCT
gs-4321	92	12	transferring	transfer	VERB
gs-4321	92	13	proteins	protein	NOUN
gs-4321	92	14	,	,	PUNCT
gs-4321	92	15	lipids	lipid	NOUN
gs-4321	92	16	,	,	PUNCT
gs-4321	92	17	and	and	CCONJ
gs-4321	92	18	nucleic	nucleic	ADJ
gs-4321	92	19	acids	acid	NOUN
gs-4321	92	20	(	(	PUNCT
gs-4321	92	21	including	include	VERB
gs-4321	92	22	micrornas	microrna	NOUN
gs-4321	92	23	and	and	CCONJ
gs-4321	92	24	transcription	transcription	NOUN
gs-4321	92	25	factors	factor	NOUN
gs-4321	92	26	)	)	PUNCT
gs-4321	92	27	between	between	ADP
gs-4321	92	28	cells	cell	NOUN
gs-4321	92	29	.	.	PUNCT
gs-4321	93	1	a	a	DET
gs-4321	93	2	stromal	stromal	ADJ
gs-4321	93	3	cell	cell	NOUN
gs-4321	93	4	can	can	AUX
gs-4321	93	5	,	,	PUNCT
gs-4321	93	6	via	via	ADP
gs-4321	93	7	exosomes	exosome	NOUN
gs-4321	93	8	,	,	PUNCT
gs-4321	93	9	deliver	deliver	VERB
gs-4321	93	10	pro	pro	ADJ
gs-4321	93	11	-	-	ADJ
gs-4321	93	12	plasticity	plasticity	ADJ
gs-4321	93	13	signals	signal	NOUN
gs-4321	93	14	directly	directly	ADV
gs-4321	93	15	to	to	ADP
gs-4321	93	16	a	a	DET
gs-4321	93	17	cancer	cancer	NOUN
gs-4321	93	18	cell	cell	NOUN
gs-4321	93	19	,	,	PUNCT
gs-4321	93	20	inducing	induce	VERB
gs-4321	93	21	transcriptional	transcriptional	ADJ
gs-4321	93	22	reprogramming	reprogramming	NOUN
gs-4321	93	23	and	and	CCONJ
gs-4321	93	24	drug	drug	NOUN
gs-4321	93	25	resistance	resistance	NOUN
gs-4321	93	26	without	without	ADP
gs-4321	93	27	direct	direct	ADJ
gs-4321	93	28	cell	cell	NOUN
gs-4321	93	29	-	-	PUNCT
gs-4321	93	30	to	to	ADP
gs-4321	93	31	-	-	PUNCT
gs-4321	93	32	cell	cell	NOUN
gs-4321	93	33	contact	contact	NOUN
gs-4321	93	34	.	.	PUNCT
gs-4321	94	1	for	for	ADP
gs-4321	94	2	decades	decade	NOUN
gs-4321	94	3	,	,	PUNCT
gs-4321	94	4	the	the	DET
gs-4321	94	5	study	study	NOUN
gs-4321	94	6	of	of	ADP
gs-4321	94	7	these	these	DET
gs-4321	94	8	complex	complex	ADJ
gs-4321	94	9	phenomena	phenomenon	NOUN
gs-4321	94	10	was	be	AUX
gs-4321	94	11	hampered	hamper	VERB
gs-4321	94	12	by	by	ADP
gs-4321	94	13	technological	technological	ADJ
gs-4321	94	14	limitations	limitation	NOUN
gs-4321	94	15	.	.	PUNCT
gs-4321	95	1	traditional	traditional	ADJ
gs-4321	95	2	bulk	bulk	ADJ
gs-4321	95	3	sequencing	sequence	VERB
gs-4321	95	4	methods	method	NOUN
gs-4321	95	5	,	,	PUNCT
gs-4321	95	6	which	which	PRON
gs-4321	95	7	analyze	analyze	VERB
gs-4321	95	8	the	the	DET
gs-4321	95	9	average	average	ADJ
gs-4321	95	10	signal	signal	NOUN
gs-4321	95	11	from	from	ADP
gs-4321	95	12	thousands	thousand	NOUN
gs-4321	95	13	or	or	CCONJ
gs-4321	95	14	millions	million	NOUN
gs-4321	95	15	of	of	ADP
gs-4321	95	16	cells	cell	NOUN
gs-4321	95	17	,	,	PUNCT
gs-4321	95	18	effectively	effectively	ADV
gs-4321	95	19	masked	mask	VERB
gs-4321	95	20	the	the	DET
gs-4321	95	21	critical	critical	ADJ
gs-4321	95	22	heterogeneity	heterogeneity	NOUN
gs-4321	95	23	within	within	ADP
gs-4321	95	24	the	the	DET
gs-4321	95	25	tme	tme	NOUN
gs-4321	95	26	.	.	PUNCT
gs-4321	96	1	the	the	DET
gs-4321	96	2	rare	rare	ADJ
gs-4321	96	3	but	but	CCONJ
gs-4321	96	4	potent	potent	ADJ
gs-4321	96	5	csc	csc	PROPN
gs-4321	96	6	populations	population	NOUN
gs-4321	96	7	and	and	CCONJ
gs-4321	96	8	the	the	DET
gs-4321	96	9	subtle	subtle	ADJ
gs-4321	96	10	transitions	transition	NOUN
gs-4321	96	11	of	of	ADP
gs-4321	96	12	plastic	plastic	ADJ
gs-4321	96	13	cells	cell	NOUN
gs-4321	96	14	were	be	AUX
gs-4321	96	15	lost	lose	VERB
gs-4321	96	16	in	in	ADP
gs-4321	96	17	the	the	DET
gs-4321	96	18	average	average	NOUN
gs-4321	96	19	,	,	PUNCT
gs-4321	96	20	like	like	ADP
gs-4321	96	21	a	a	DET
gs-4321	96	22	single	single	ADJ
gs-4321	96	23	voice	voice	NOUN
gs-4321	96	24	in	in	ADP
gs-4321	96	25	a	a	DET
gs-4321	96	26	roaring	roar	VERB
gs-4321	96	27	crowd	crowd	NOUN
gs-4321	96	28	.	.	PUNCT
gs-4321	97	1	this	this	DET
gs-4321	97	2	analytical	analytical	ADJ
gs-4321	97	3	blind	blind	ADJ
gs-4321	97	4	spot	spot	NOUN
gs-4321	97	5	prevented	prevent	VERB
gs-4321	97	6	a	a	DET
gs-4321	97	7	true	true	ADJ
gs-4321	97	8	understanding	understanding	NOUN
gs-4321	97	9	of	of	ADP
gs-4321	97	10	the	the	DET
gs-4321	97	11	lineage	lineage	NOUN
gs-4321	97	12	relationships	relationship	NOUN
gs-4321	97	13	and	and	CCONJ
gs-4321	97	14	dynamic	dynamic	ADJ
gs-4321	97	15	state	state	NOUN
gs-4321	97	16	transitions	transition	NOUN
gs-4321	97	17	that	that	PRON
gs-4321	97	18	characterize	characterize	VERB
gs-4321	97	19	tumor	tumor	NOUN
gs-4321	97	20	evolution	evolution	NOUN
gs-4321	97	21	.	.	PUNCT
gs-4321	98	1	the	the	DET
gs-4321	98	2	advent	advent	NOUN
gs-4321	98	3	of	of	ADP
gs-4321	98	4	single	single	ADJ
gs-4321	98	5	-	-	PUNCT
gs-4321	98	6	cell	cell	NOUN
gs-4321	98	7	technologies	technology	NOUN
gs-4321	98	8	has	have	AUX
gs-4321	98	9	heralded	herald	VERB
gs-4321	98	10	a	a	DET
gs-4321	98	11	revolution	revolution	NOUN
gs-4321	98	12	,	,	PUNCT
gs-4321	98	13	allowing	allow	VERB
gs-4321	98	14	researchers	researcher	NOUN
gs-4321	98	15	to	to	PART
gs-4321	98	16	deconstruct	deconstruct	VERB
gs-4321	98	17	the	the	DET
gs-4321	98	18	tme	tme	NOUN
gs-4321	98	19	one	one	NUM
gs-4321	98	20	cell	cell	NOUN
gs-4321	98	21	at	at	ADP
gs-4321	98	22	a	a	DET
gs-4321	98	23	time	time	NOUN
gs-4321	98	24	.	.	PUNCT
gs-4321	99	1	single	single	ADJ
gs-4321	99	2	-	-	PUNCT
gs-4321	99	3	cell	cell	NOUN
gs-4321	99	4	rna	rna	NOUN
gs-4321	99	5	sequencing	sequence	VERB
gs-4321	99	6	(	(	PUNCT
gs-4321	99	7	scrna	scrna	NOUN
gs-4321	99	8	-	-	PUNCT
gs-4321	99	9	seq	seq	NOUN
gs-4321	99	10	)	)	PUNCT
gs-4321	99	11	provides	provide	VERB
gs-4321	99	12	a	a	DET
gs-4321	99	13	high	high	ADJ
gs-4321	99	14	-	-	PUNCT
gs-4321	99	15	resolution	resolution	NOUN
gs-4321	99	16	transcriptomic	transcriptomic	ADJ
gs-4321	99	17	map	map	NOUN
gs-4321	99	18	,	,	PUNCT
gs-4321	99	19	revealing	reveal	VERB
gs-4321	99	20	previously	previously	ADV
gs-4321	99	21	hidden	hide	VERB
gs-4321	99	22	subpopulations	subpopulation	NOUN
gs-4321	99	23	.	.	PUNCT
gs-4321	100	1	singlecell	singlecell	VERB
gs-4321	100	2	atac	atac	NOUN
gs-4321	100	3	-	-	PUNCT
gs-4321	100	4	seq	seq	NOUN
gs-4321	100	5	(	(	PUNCT
gs-4321	100	6	scatac	scatac	NOUN
gs-4321	100	7	-	-	PUNCT
gs-4321	100	8	seq	seq	NOUN
gs-4321	100	9	)	)	PUNCT
gs-4321	100	10	charts	chart	VERB
gs-4321	100	11	the	the	DET
gs-4321	100	12	landscape	landscape	NOUN
gs-4321	100	13	of	of	ADP
gs-4321	100	14	chromatin	chromatin	NOUN
gs-4321	100	15	accessibility	accessibility	NOUN
gs-4321	100	16	,	,	PUNCT
gs-4321	100	17	revealing	reveal	VERB
gs-4321	100	18	the	the	DET
gs-4321	100	19	epigenetic	epigenetic	ADJ
gs-4321	100	20	underpinnings	underpinning	NOUN
gs-4321	100	21	of	of	ADP
gs-4321	100	22	cellular	cellular	ADJ
gs-4321	100	23	identity	identity	NOUN
gs-4321	100	24	.	.	PUNCT
gs-4321	101	1	multimodal	multimodal	NOUN
gs-4321	101	2	technologies	technology	NOUN
gs-4321	101	3	,	,	PUNCT
gs-4321	101	4	such	such	ADJ
gs-4321	101	5	as	as	ADP
gs-4321	101	6	cite	cite	NOUN
gs-4321	101	7	-	-	PUNCT
gs-4321	101	8	seq	seq	NOUN
gs-4321	101	9	and	and	CCONJ
gs-4321	101	10	share	share	NOUN
gs-4321	101	11	-	-	PUNCT
gs-4321	101	12	seq	seq	NOUN
gs-4321	101	13	,	,	PUNCT
gs-4321	101	14	now	now	ADV
gs-4321	101	15	allow	allow	VERB
gs-4321	101	16	for	for	ADP
gs-4321	101	17	the	the	DET
gs-4321	101	18	simultaneous	simultaneous	ADJ
gs-4321	101	19	measurement	measurement	NOUN
gs-4321	101	20	of	of	ADP
gs-4321	101	21	transcriptome	transcriptome	PROPN
gs-4321	101	22	,	,	PUNCT
gs-4321	101	23	epigenome	epigenome	NOUN
gs-4321	101	24	,	,	PUNCT
gs-4321	101	25	and	and	CCONJ
gs-4321	101	26	surface	surface	NOUN
gs-4321	101	27	protein	protein	NOUN
gs-4321	101	28	expression	expression	NOUN
gs-4321	101	29	from	from	ADP
gs-4321	101	30	the	the	DET
gs-4321	101	31	same	same	ADJ
gs-4321	101	32	single	single	ADJ
gs-4321	101	33	cell	cell	NOUN
gs-4321	101	34	.	.	PUNCT
gs-4321	102	1	furthermore	furthermore	ADV
gs-4321	102	2	,	,	PUNCT
gs-4321	102	3	spatial	spatial	ADJ
gs-4321	102	4	transcriptomics	transcriptomic	NOUN
gs-4321	102	5	platforms	platform	NOUN
gs-4321	102	6	like	like	ADP
gs-4321	102	7	10x	10x	PROPN
gs-4321	102	8	visium	visium	NOUN
gs-4321	102	9	and	and	CCONJ
gs-4321	102	10	merfish	merfish	PROPN
gs-4321	102	11	preserve	preserve	VERB
gs-4321	102	12	the	the	DET
gs-4321	102	13	anatomical	anatomical	ADJ
gs-4321	102	14	context	context	NOUN
gs-4321	102	15	,	,	PUNCT
gs-4321	102	16	enabling	enable	VERB
gs-4321	102	17	researchers	researcher	NOUN
gs-4321	102	18	to	to	PART
gs-4321	102	19	see	see	VERB
gs-4321	102	20	not	not	PART
gs-4321	102	21	only	only	ADV
gs-4321	102	22	what	what	PRON
gs-4321	102	23	a	a	DET
gs-4321	102	24	cell	cell	NOUN
gs-4321	102	25	is	be	AUX
gs-4321	102	26	,	,	PUNCT
gs-4321	102	27	but	but	CCONJ
gs-4321	102	28	where	where	SCONJ
gs-4321	102	29	it	it	PRON
gs-4321	102	30	is	be	AUX
gs-4321	102	31	located	locate	VERB
gs-4321	102	32	within	within	ADP
gs-4321	102	33	the	the	DET
gs-4321	102	34	tumor	tumor	NOUN
gs-4321	102	35	architecture	architecture	NOUN
gs-4321	102	36	—	—	PUNCT
gs-4321	102	37	revealing	reveal	VERB
gs-4321	102	38	the	the	DET
gs-4321	102	39	specific	specific	ADJ
gs-4321	102	40	niches	niche	NOUN
gs-4321	102	41	that	that	PRON
gs-4321	102	42	foster	foster	ADJ
gs-4321	102	43	plasticity	plasticity	NOUN
gs-4321	102	44	.	.	PUNCT
gs-4321	103	1	however	however	ADV
gs-4321	103	2	,	,	PUNCT
gs-4321	103	3	this	this	DET
gs-4321	103	4	technological	technological	ADJ
gs-4321	103	5	leap	leap	NOUN
gs-4321	103	6	has	have	AUX
gs-4321	103	7	created	create	VERB
gs-4321	103	8	a	a	DET
gs-4321	103	9	new	new	ADJ
gs-4321	103	10	challenge	challenge	NOUN
gs-4321	103	11	:	:	PUNCT
gs-4321	103	12	data	datum	NOUN
gs-4321	103	13	complexity	complexity	NOUN
gs-4321	103	14	.	.	PUNCT
gs-4321	104	1	the	the	DET
gs-4321	104	2	immense	immense	ADJ
gs-4321	104	3	,	,	PUNCT
gs-4321	104	4	high	high	ADJ
gs-4321	104	5	-	-	PUNCT
gs-4321	104	6	dimensional	dimensional	ADJ
gs-4321	104	7	datasets	dataset	NOUN
gs-4321	104	8	generated	generate	VERB
gs-4321	104	9	by	by	ADP
gs-4321	104	10	single	single	ADJ
gs-4321	104	11	-	-	PUNCT
gs-4321	104	12	cell	cell	NOUN
gs-4321	104	13	technologies	technology	NOUN
gs-4321	104	14	are	be	AUX
gs-4321	104	15	incomprehensible	incomprehensible	ADJ
gs-4321	104	16	to	to	ADP
gs-4321	104	17	the	the	DET
gs-4321	104	18	human	human	ADJ
gs-4321	104	19	eye	eye	NOUN
gs-4321	104	20	alone	alone	ADV
gs-4321	104	21	.	.	PUNCT
gs-4321	105	1	this	this	PRON
gs-4321	105	2	is	be	AUX
gs-4321	105	3	where	where	SCONJ
gs-4321	105	4	bioinformatics	bioinformatics	NOUN
gs-4321	105	5	and	and	CCONJ
gs-4321	105	6	computational	computational	ADJ
gs-4321	105	7	biology	biology	NOUN
gs-4321	105	8	have	have	AUX
gs-4321	105	9	become	become	VERB
gs-4321	105	10	indispensable	indispensable	ADJ
gs-4321	105	11	.	.	PUNCT
gs-4321	106	1	the	the	DET
gs-4321	106	2	field	field	NOUN
gs-4321	106	3	has	have	AUX
gs-4321	106	4	developed	develop	VERB
gs-4321	106	5	a	a	DET
gs-4321	106	6	sophisticated	sophisticated	ADJ
gs-4321	106	7	toolkit	toolkit	NOUN
gs-4321	106	8	to	to	PART
gs-4321	106	9	make	make	VERB
gs-4321	106	10	sense	sense	NOUN
gs-4321	106	11	of	of	ADP
gs-4321	106	12	this	this	DET
gs-4321	106	13	complexity	complexity	NOUN
gs-4321	106	14	.	.	PUNCT
gs-4321	107	1	dimensionality	dimensionality	NOUN
gs-4321	107	2	reduction	reduction	NOUN
gs-4321	107	3	algorithms	algorithm	NOUN
gs-4321	107	4	like	like	INTJ
gs-4321	107	5	umap	umap	NOUN
gs-4321	107	6	and	and	CCONJ
gs-4321	107	7	t	t	PROPN
gs-4321	107	8	-	-	PUNCT
gs-4321	107	9	sne	sne	NOUN
gs-4321	107	10	create	create	VERB
gs-4321	107	11	visualizable	visualizable	ADJ
gs-4321	107	12	maps	map	NOUN
gs-4321	107	13	of	of	ADP
gs-4321	107	14	cellular	cellular	ADJ
gs-4321	107	15	states	state	NOUN
gs-4321	107	16	.	.	PUNCT
gs-4321	108	1	clustering	cluster	VERB
gs-4321	108	2	algorithms	algorithm	NOUN
gs-4321	108	3	identify	identify	VERB
gs-4321	108	4	distinct	distinct	ADJ
gs-4321	108	5	subpopulations	subpopulation	NOUN
gs-4321	108	6	.	.	PUNCT
gs-4321	109	1	trajectory	trajectory	NOUN
gs-4321	109	2	inference	inference	NOUN
gs-4321	109	3	tools	tool	NOUN
gs-4321	109	4	(	(	PUNCT
gs-4321	109	5	e.g.	e.g.	ADV
gs-4321	109	6	,	,	PUNCT
gs-4321	109	7	monocle	monocle	NOUN
gs-4321	109	8	,	,	PUNCT
gs-4321	109	9	slingshot	slingshot	NOUN
gs-4321	109	10	)	)	PUNCT
gs-4321	109	11	reconstruct	reconstruct	VERB
gs-4321	109	12	the	the	DET
gs-4321	109	13	developmental	developmental	ADJ
gs-4321	109	14	paths	path	NOUN
gs-4321	109	15	cells	cell	NOUN
gs-4321	109	16	take	take	VERB
gs-4321	109	17	as	as	SCONJ
gs-4321	109	18	they	they	PRON
gs-4321	109	19	transition	transition	VERB
gs-4321	109	20	between	between	ADP
gs-4321	109	21	states	state	NOUN
gs-4321	109	22	,	,	PUNCT
gs-4321	109	23	effectively	effectively	ADV
gs-4321	109	24	creating	create	VERB
gs-4321	109	25	a	a	DET
gs-4321	109	26	"	"	PUNCT
gs-4321	109	27	pseudotime	pseudotime	ADJ
gs-4321	109	28	"	"	PUNCT
gs-4321	109	29	lineage	lineage	NOUN
gs-4321	109	30	.	.	PUNCT
gs-4321	110	1	rna	rna	NOUN
gs-4321	110	2	velocity	velocity	NOUN
gs-4321	110	3	analysis	analysis	NOUN
gs-4321	110	4	can	can	AUX
gs-4321	110	5	predict	predict	VERB
gs-4321	110	6	the	the	DET
gs-4321	110	7	future	future	ADJ
gs-4321	110	8	state	state	NOUN
gs-4321	110	9	of	of	ADP
gs-4321	110	10	a	a	DET
gs-4321	110	11	cell	cell	NOUN
gs-4321	110	12	based	base	VERB
gs-4321	110	13	on	on	ADP
gs-4321	110	14	its	its	PRON
gs-4321	110	15	ratio	ratio	NOUN
gs-4321	110	16	of	of	ADP
gs-4321	110	17	unspliced	unspliced	ADJ
gs-4321	110	18	to	to	ADP
gs-4321	110	19	spliced	spliced	ADJ
gs-4321	110	20	rna	rna	NOUN
gs-4321	110	21	.	.	PUNCT
gs-4321	111	1	gene	gene	NOUN
gs-4321	111	2	regulatory	regulatory	ADJ
gs-4321	111	3	network	network	NOUN
gs-4321	111	4	(	(	PUNCT
gs-4321	111	5	grn	grn	PROPN
gs-4321	111	6	)	)	PUNCT
gs-4321	111	7	inference	inference	NOUN
gs-4321	111	8	tools	tool	NOUN
gs-4321	111	9	like	like	ADP
gs-4321	111	10	scenic	scenic	ADJ
gs-4321	111	11	identify	identify	VERB
gs-4321	111	12	the	the	DET
gs-4321	111	13	master	master	NOUN
gs-4321	111	14	transcription	transcription	NOUN
gs-4321	111	15	factors	factor	NOUN
gs-4321	111	16	controlling	control	VERB
gs-4321	111	17	these	these	DET
gs-4321	111	18	transitions	transition	NOUN
gs-4321	111	19	.	.	PUNCT
gs-4321	112	1	finally	finally	ADV
gs-4321	112	2	,	,	PUNCT
gs-4321	112	3	cell	cell	NOUN
gs-4321	112	4	-	-	PUNCT
gs-4321	112	5	cell	cell	NOUN
gs-4321	112	6	communication	communication	NOUN
gs-4321	112	7	inference	inference	NOUN
gs-4321	112	8	tools	tool	NOUN
gs-4321	112	9	(	(	PUNCT
gs-4321	112	10	e.g.	e.g.	ADV
gs-4321	112	11	,	,	PUNCT
gs-4321	112	12	cellchat	cellchat	NOUN
gs-4321	112	13	,	,	PUNCT
gs-4321	112	14	nichenet	nichenet	NOUN
gs-4321	112	15	)	)	PUNCT
gs-4321	112	16	systematically	systematically	ADV
gs-4321	112	17	map	map	VERB
gs-4321	112	18	the	the	DET
gs-4321	112	19	web	web	NOUN
gs-4321	112	20	of	of	ADP
gs-4321	112	21	ligand	ligand	NOUN
gs-4321	112	22	-	-	PUNCT
gs-4321	112	23	receptor	receptor	NOUN
gs-4321	112	24	interactions	interaction	NOUN
gs-4321	112	25	between	between	ADP
gs-4321	112	26	different	different	ADJ
gs-4321	112	27	cell	cell	NOUN
gs-4321	112	28	types	type	NOUN
gs-4321	112	29	in	in	ADP
gs-4321	112	30	the	the	DET
gs-4321	112	31	tme	tme	NOUN
gs-4321	112	32	.	.	PUNCT
gs-4321	113	1	it	it	PRON
gs-4321	113	2	is	be	AUX
gs-4321	113	3	at	at	ADP
gs-4321	113	4	the	the	DET
gs-4321	113	5	intersection	intersection	NOUN
gs-4321	113	6	of	of	ADP
gs-4321	113	7	single	single	ADJ
gs-4321	113	8	-	-	PUNCT
gs-4321	113	9	cell	cell	NOUN
gs-4321	113	10	biology	biology	NOUN
gs-4321	113	11	and	and	CCONJ
gs-4321	113	12	advanced	advanced	ADJ
gs-4321	113	13	bioinformatics	bioinformatic	NOUN
gs-4321	113	14	that	that	SCONJ
gs-4321	113	15	this	this	DET
gs-4321	113	16	study	study	NOUN
gs-4321	113	17	positions	position	VERB
gs-4321	113	18	itself	itself	PRON
gs-4321	113	19	.	.	PUNCT
gs-4321	114	1	the	the	DET
gs-4321	114	2	central	central	ADJ
gs-4321	114	3	premise	premise	NOUN
gs-4321	114	4	is	be	AUX
gs-4321	114	5	that	that	PRON
gs-4321	114	6	to	to	PART
gs-4321	114	7	truly	truly	ADV
gs-4321	114	8	conquer	conquer	VERB
gs-4321	114	9	therapeutic	therapeutic	ADJ
gs-4321	114	10	resistance	resistance	NOUN
gs-4321	114	11	,	,	PUNCT
gs-4321	114	12	we	we	PRON
gs-4321	114	13	must	must	AUX
gs-4321	114	14	move	move	VERB
gs-4321	114	15	beyond	beyond	ADP
gs-4321	114	16	a	a	DET
gs-4321	114	17	static	static	ADJ
gs-4321	114	18	catalog	catalog	NOUN
gs-4321	114	19	of	of	ADP
gs-4321	114	20	cancer	cancer	NOUN
gs-4321	114	21	cell	cell	NOUN
gs-4321	114	22	types	type	NOUN
gs-4321	114	23	and	and	CCONJ
gs-4321	114	24	instead	instead	ADV
gs-4321	114	25	decode	decode	VERB
gs-4321	114	26	the	the	DET
gs-4321	114	27	dynamic	dynamic	ADJ
gs-4321	114	28	,	,	PUNCT
gs-4321	114	29	reversible	reversible	ADJ
gs-4321	114	30	,	,	PUNCT
gs-4321	114	31	and	and	CCONJ
gs-4321	114	32	adaptive	adaptive	ADJ
gs-4321	114	33	processes	process	NOUN
gs-4321	114	34	that	that	PRON
gs-4321	114	35	allow	allow	VERB
gs-4321	114	36	tumors	tumor	NOUN
gs-4321	114	37	to	to	PART
gs-4321	114	38	survive	survive	VERB
gs-4321	114	39	.	.	PUNCT
gs-4321	115	1	by	by	ADP
gs-4321	115	2	building	build	VERB
gs-4321	115	3	an	an	DET
gs-4321	115	4	integrative	integrative	ADJ
gs-4321	115	5	bioinformatic	bioinformatic	ADJ
gs-4321	115	6	framework	framework	NOUN
gs-4321	115	7	that	that	PRON
gs-4321	115	8	synthesizes	synthesize	VERB
gs-4321	115	9	multi	multi	ADJ
gs-4321	115	10	-	-	ADJ
gs-4321	115	11	omics	omics	ADJ
gs-4321	115	12	data	datum	NOUN
gs-4321	115	13	—	—	PUNCT
gs-4321	115	14	transcriptomics	transcriptomic	NOUN
gs-4321	115	15	,	,	PUNCT
gs-4321	115	16	proteomics	proteomic	NOUN
gs-4321	115	17	,	,	PUNCT
gs-4321	115	18	georgian	georgian	NOUN
gs-4321	115	19	scientists/	scientists/	NUM
gs-4321	115	20	.	.	PUNCT
gs-4321	115	21	7	7	NUM
gs-4321	115	22	n	n	DET
gs-4321	115	23	4	4	NUM
gs-4321	115	24	,	,	PUNCT
gs-4321	115	25	2025	2025	NUM
gs-4321	115	26	340	340	NUM
gs-4321	115	27	epigenomics	epigenomic	NOUN
gs-4321	115	28	,	,	PUNCT
gs-4321	115	29	and	and	CCONJ
gs-4321	115	30	spatial	spatial	ADJ
gs-4321	115	31	context	context	NOUN
gs-4321	115	32	—	—	PUNCT
gs-4321	115	33	this	this	DET
gs-4321	115	34	research	research	NOUN
gs-4321	115	35	aims	aim	VERB
gs-4321	115	36	to	to	PART
gs-4321	115	37	dissect	dissect	VERB
gs-4321	115	38	the	the	DET
gs-4321	115	39	fundamental	fundamental	ADJ
gs-4321	115	40	rules	rule	NOUN
gs-4321	115	41	of	of	ADP
gs-4321	115	42	csc	csc	PROPN
gs-4321	115	43	plasticity	plasticity	NOUN
gs-4321	115	44	.	.	PUNCT
gs-4321	116	1	it	it	PRON
gs-4321	116	2	seeks	seek	VERB
gs-4321	116	3	to	to	PART
gs-4321	116	4	identify	identify	VERB
gs-4321	116	5	the	the	DET
gs-4321	116	6	conserved	conserve	VERB
gs-4321	116	7	molecular	molecular	ADJ
gs-4321	116	8	programs	program	NOUN
gs-4321	116	9	,	,	PUNCT
gs-4321	116	10	the	the	DET
gs-4321	116	11	key	key	ADJ
gs-4321	116	12	regulatory	regulatory	ADJ
gs-4321	116	13	nodes	node	NOUN
gs-4321	116	14	,	,	PUNCT
gs-4321	116	15	and	and	CCONJ
gs-4321	116	16	the	the	DET
gs-4321	116	17	critical	critical	ADJ
gs-4321	116	18	microenvironmental	microenvironmental	ADJ
gs-4321	116	19	signals	signal	NOUN
gs-4321	116	20	that	that	PRON
gs-4321	116	21	govern	govern	VERB
gs-4321	116	22	phenotypic	phenotypic	ADJ
gs-4321	116	23	transitions	transition	NOUN
gs-4321	116	24	across	across	ADP
gs-4321	116	25	diverse	diverse	ADJ
gs-4321	116	26	cancer	cancer	NOUN
gs-4321	116	27	types	type	NOUN
gs-4321	116	28	.	.	PUNCT
gs-4321	117	1	the	the	DET
gs-4321	117	2	ultimate	ultimate	ADJ
gs-4321	117	3	goal	goal	NOUN
gs-4321	117	4	is	be	AUX
gs-4321	117	5	to	to	PART
gs-4321	117	6	translate	translate	VERB
gs-4321	117	7	this	this	DET
gs-4321	117	8	systems	system	NOUN
gs-4321	117	9	-	-	PUNCT
gs-4321	117	10	level	level	NOUN
gs-4321	117	11	understanding	understanding	NOUN
gs-4321	117	12	into	into	ADP
gs-4321	117	13	novel	novel	ADJ
gs-4321	117	14	therapeutic	therapeutic	ADJ
gs-4321	117	15	strategies	strategy	NOUN
gs-4321	117	16	that	that	PRON
gs-4321	117	17	can	can	AUX
gs-4321	117	18	target	target	VERB
gs-4321	117	19	the	the	DET
gs-4321	117	20	very	very	ADJ
gs-4321	117	21	engine	engine	NOUN
gs-4321	117	22	of	of	ADP
gs-4321	117	23	tumor	tumor	NOUN
gs-4321	117	24	adaptation	adaptation	NOUN
gs-4321	117	25	,	,	PUNCT
gs-4321	117	26	preventing	prevent	VERB
gs-4321	117	27	resistance	resistance	NOUN
gs-4321	117	28	and	and	CCONJ
gs-4321	117	29	improving	improve	VERB
gs-4321	117	30	outcomes	outcome	NOUN
gs-4321	117	31	for	for	ADP
gs-4321	117	32	patients	patient	NOUN
gs-4321	117	33	with	with	ADP
gs-4321	117	34	cancer	cancer	NOUN
gs-4321	117	35	.	.	PUNCT
gs-4321	118	1	the	the	DET
gs-4321	118	2	tumor	tumor	NOUN
gs-4321	118	3	microenvironment	microenvironment	NOUN
gs-4321	118	4	(	(	PUNCT
gs-4321	118	5	tme	tme	NOUN
gs-4321	118	6	)	)	PUNCT
gs-4321	118	7	has	have	AUX
gs-4321	118	8	emerged	emerge	VERB
gs-4321	118	9	as	as	ADP
gs-4321	118	10	a	a	DET
gs-4321	118	11	dynamic	dynamic	ADJ
gs-4321	118	12	and	and	CCONJ
gs-4321	118	13	biologically	biologically	ADV
gs-4321	118	14	complex	complex	ADJ
gs-4321	118	15	ecosystem	ecosystem	NOUN
gs-4321	118	16	that	that	PRON
gs-4321	118	17	profoundly	profoundly	ADV
gs-4321	118	18	influences	influence	VERB
gs-4321	118	19	cancer	cancer	NOUN
gs-4321	118	20	initiation	initiation	NOUN
gs-4321	118	21	,	,	PUNCT
gs-4321	118	22	progression	progression	NOUN
gs-4321	118	23	,	,	PUNCT
gs-4321	118	24	metastasis	metastasis	NOUN
gs-4321	118	25	,	,	PUNCT
gs-4321	118	26	and	and	CCONJ
gs-4321	118	27	therapeutic	therapeutic	ADJ
gs-4321	118	28	response	response	NOUN
gs-4321	118	29	.	.	PUNCT
gs-4321	119	1	rather	rather	ADV
gs-4321	119	2	than	than	ADP
gs-4321	119	3	being	be	AUX
gs-4321	119	4	composed	compose	VERB
gs-4321	119	5	solely	solely	ADV
gs-4321	119	6	of	of	ADP
gs-4321	119	7	malignant	malignant	ADJ
gs-4321	119	8	cells	cell	NOUN
gs-4321	119	9	,	,	PUNCT
gs-4321	119	10	tumors	tumor	NOUN
gs-4321	119	11	exist	exist	VERB
gs-4321	119	12	within	within	ADP
gs-4321	119	13	a	a	DET
gs-4321	119	14	heterogeneous	heterogeneous	ADJ
gs-4321	119	15	milieu	milieu	NOUN
gs-4321	119	16	of	of	ADP
gs-4321	119	17	stromal	stromal	ADJ
gs-4321	119	18	components	component	NOUN
gs-4321	119	19	,	,	PUNCT
gs-4321	119	20	immune	immune	ADJ
gs-4321	119	21	cells	cell	NOUN
gs-4321	119	22	,	,	PUNCT
gs-4321	119	23	vascular	vascular	ADJ
gs-4321	119	24	networks	network	NOUN
gs-4321	119	25	,	,	PUNCT
gs-4321	119	26	extracellular	extracellular	ADJ
gs-4321	119	27	matrix	matrix	NOUN
gs-4321	119	28	structures	structure	NOUN
gs-4321	119	29	,	,	PUNCT
gs-4321	119	30	and	and	CCONJ
gs-4321	119	31	a	a	DET
gs-4321	119	32	wide	wide	ADJ
gs-4321	119	33	array	array	NOUN
gs-4321	119	34	of	of	ADP
gs-4321	119	35	signaling	signal	VERB
gs-4321	119	36	molecules	molecule	NOUN
gs-4321	119	37	that	that	PRON
gs-4321	119	38	collectively	collectively	ADV
gs-4321	119	39	shape	shape	VERB
gs-4321	119	40	tumor	tumor	NOUN
gs-4321	119	41	behavior	behavior	NOUN
gs-4321	119	42	.	.	PUNCT
gs-4321	120	1	growing	grow	VERB
gs-4321	120	2	evidence	evidence	NOUN
gs-4321	120	3	indicates	indicate	VERB
gs-4321	120	4	that	that	SCONJ
gs-4321	120	5	this	this	DET
gs-4321	120	6	microenvironment	microenvironment	NOUN
gs-4321	120	7	is	be	AUX
gs-4321	120	8	not	not	PART
gs-4321	120	9	merely	merely	ADV
gs-4321	120	10	a	a	DET
gs-4321	120	11	passive	passive	ADJ
gs-4321	120	12	scaffold	scaffold	NOUN
gs-4321	120	13	but	but	CCONJ
gs-4321	120	14	an	an	DET
gs-4321	120	15	active	active	ADJ
gs-4321	120	16	participant	participant	NOUN
gs-4321	120	17	that	that	PRON
gs-4321	120	18	governs	govern	VERB
gs-4321	120	19	key	key	ADJ
gs-4321	120	20	oncogenic	oncogenic	ADJ
gs-4321	120	21	processes	process	NOUN
gs-4321	120	22	such	such	ADJ
gs-4321	120	23	as	as	ADP
gs-4321	120	24	immune	immune	ADJ
gs-4321	120	25	evasion	evasion	NOUN
gs-4321	120	26	,	,	PUNCT
gs-4321	120	27	metabolic	metabolic	NOUN
gs-4321	120	28	reprogramming	reprogramming	NOUN
gs-4321	120	29	,	,	PUNCT
gs-4321	120	30	angiogenesis	angiogenesis	NOUN
gs-4321	120	31	,	,	PUNCT
gs-4321	120	32	and	and	CCONJ
gs-4321	120	33	resistance	resistance	NOUN
gs-4321	120	34	to	to	ADP
gs-4321	120	35	treatment	treatment	NOUN
gs-4321	120	36	.	.	PUNCT
gs-4321	121	1	traditional	traditional	ADJ
gs-4321	121	2	molecular	molecular	ADJ
gs-4321	121	3	profiling	profiling	NOUN
gs-4321	121	4	has	have	AUX
gs-4321	121	5	offered	offer	VERB
gs-4321	121	6	valuable	valuable	ADJ
gs-4321	121	7	insights	insight	NOUN
gs-4321	121	8	into	into	ADP
gs-4321	121	9	tumor	tumor	NOUN
gs-4321	121	10	biology	biology	NOUN
gs-4321	121	11	,	,	PUNCT
gs-4321	121	12	yet	yet	CCONJ
gs-4321	121	13	it	it	PRON
gs-4321	121	14	often	often	ADV
gs-4321	121	15	fails	fail	VERB
gs-4321	121	16	to	to	PART
gs-4321	121	17	capture	capture	VERB
gs-4321	121	18	the	the	DET
gs-4321	121	19	multi	multi	ADJ
gs-4321	121	20	-	-	ADJ
gs-4321	121	21	layered	layered	ADJ
gs-4321	121	22	interactions	interaction	NOUN
gs-4321	121	23	occurring	occur	VERB
gs-4321	121	24	within	within	ADP
gs-4321	121	25	the	the	DET
gs-4321	121	26	tme	tme	NOUN
gs-4321	121	27	.	.	PUNCT
gs-4321	122	1	the	the	DET
gs-4321	122	2	advent	advent	NOUN
gs-4321	122	3	of	of	ADP
gs-4321	122	4	multi	multi	ADJ
gs-4321	122	5	-	-	ADJ
gs-4321	122	6	omics	omics	ADJ
gs-4321	122	7	technologies	technology	NOUN
gs-4321	122	8	—	—	PUNCT
gs-4321	122	9	including	include	VERB
gs-4321	122	10	genomics	genomic	NOUN
gs-4321	122	11	,	,	PUNCT
gs-4321	122	12	transcriptomics	transcriptomic	NOUN
gs-4321	122	13	,	,	PUNCT
gs-4321	122	14	proteomics	proteomic	NOUN
gs-4321	122	15	,	,	PUNCT
gs-4321	122	16	metabolomics	metabolomic	NOUN
gs-4321	122	17	,	,	PUNCT
gs-4321	122	18	and	and	CCONJ
gs-4321	122	19	epigenomics	epigenomic	NOUN
gs-4321	122	20	—	—	PUNCT
gs-4321	122	21	has	have	AUX
gs-4321	122	22	enabled	enable	VERB
gs-4321	122	23	a	a	DET
gs-4321	122	24	more	more	ADV
gs-4321	122	25	holistic	holistic	ADJ
gs-4321	122	26	and	and	CCONJ
gs-4321	122	27	integrative	integrative	ADJ
gs-4321	122	28	understanding	understanding	NOUN
gs-4321	122	29	of	of	ADP
gs-4321	122	30	cancer	cancer	NOUN
gs-4321	122	31	complexity	complexity	NOUN
gs-4321	122	32	.	.	PUNCT
gs-4321	123	1	these	these	DET
gs-4321	123	2	approaches	approach	NOUN
gs-4321	123	3	reveal	reveal	VERB
gs-4321	123	4	functional	functional	ADJ
gs-4321	123	5	relationships	relationship	NOUN
gs-4321	123	6	between	between	ADP
gs-4321	123	7	molecular	molecular	ADJ
gs-4321	123	8	layers	layer	NOUN
gs-4321	123	9	and	and	CCONJ
gs-4321	123	10	uncover	uncover	VERB
gs-4321	123	11	regulatory	regulatory	ADJ
gs-4321	123	12	mechanisms	mechanism	NOUN
gs-4321	123	13	that	that	PRON
gs-4321	123	14	can	can	AUX
gs-4321	123	15	not	not	PART
gs-4321	123	16	be	be	AUX
gs-4321	123	17	inferred	infer	VERB
gs-4321	123	18	from	from	ADP
gs-4321	123	19	single	single	ADJ
gs-4321	123	20	-	-	PUNCT
gs-4321	123	21	omic	omic	ADJ
gs-4321	123	22	data	datum	NOUN
gs-4321	123	23	alone	alone	ADV
gs-4321	123	24	.	.	PUNCT
gs-4321	124	1	proteomics	proteomic	NOUN
gs-4321	124	2	has	have	AUX
gs-4321	124	3	become	become	VERB
gs-4321	124	4	especially	especially	ADV
gs-4321	124	5	important	important	ADJ
gs-4321	124	6	for	for	ADP
gs-4321	124	7	characterizing	characterize	VERB
gs-4321	124	8	the	the	DET
gs-4321	124	9	functional	functional	ADJ
gs-4321	124	10	composition	composition	NOUN
gs-4321	124	11	of	of	ADP
gs-4321	124	12	the	the	DET
gs-4321	124	13	tme	tme	NOUN
gs-4321	124	14	because	because	SCONJ
gs-4321	124	15	proteins	protein	NOUN
gs-4321	124	16	serve	serve	VERB
gs-4321	124	17	as	as	ADP
gs-4321	124	18	the	the	DET
gs-4321	124	19	direct	direct	ADJ
gs-4321	124	20	effectors	effector	NOUN
gs-4321	124	21	of	of	ADP
gs-4321	124	22	cellular	cellular	ADJ
gs-4321	124	23	activity	activity	NOUN
gs-4321	124	24	and	and	CCONJ
gs-4321	124	25	therapeutic	therapeutic	ADJ
gs-4321	124	26	targets	target	NOUN
gs-4321	124	27	.	.	PUNCT
gs-4321	125	1	high	high	ADJ
gs-4321	125	2	-	-	PUNCT
gs-4321	125	3	resolution	resolution	NOUN
gs-4321	125	4	proteomic	proteomic	NOUN
gs-4321	125	5	platforms	platform	NOUN
gs-4321	125	6	now	now	ADV
gs-4321	125	7	make	make	VERB
gs-4321	125	8	it	it	PRON
gs-4321	125	9	possible	possible	ADJ
gs-4321	125	10	to	to	PART
gs-4321	125	11	quantify	quantify	VERB
gs-4321	125	12	alterations	alteration	NOUN
gs-4321	125	13	in	in	ADP
gs-4321	125	14	signaling	signal	VERB
gs-4321	125	15	pathways	pathway	NOUN
gs-4321	125	16	,	,	PUNCT
gs-4321	125	17	immune	immune	ADJ
gs-4321	125	18	checkpoints	checkpoint	NOUN
gs-4321	125	19	,	,	PUNCT
gs-4321	125	20	metabolic	metabolic	NOUN
gs-4321	125	21	enzymes	enzyme	NOUN
gs-4321	125	22	,	,	PUNCT
gs-4321	125	23	and	and	CCONJ
gs-4321	125	24	extracellular	extracellular	ADJ
gs-4321	125	25	matrix	matrix	NOUN
gs-4321	125	26	proteins	protein	NOUN
gs-4321	125	27	,	,	PUNCT
gs-4321	125	28	providing	provide	VERB
gs-4321	125	29	mechanistic	mechanistic	ADJ
gs-4321	125	30	insight	insight	NOUN
gs-4321	125	31	into	into	ADP
gs-4321	125	32	tumor	tumor	NOUN
gs-4321	125	33	–	–	PUNCT
gs-4321	125	34	stromal	stromal	ADJ
gs-4321	125	35	communication	communication	NOUN
gs-4321	125	36	.	.	PUNCT
gs-4321	126	1	exosomes	exosome	NOUN
gs-4321	126	2	and	and	CCONJ
gs-4321	126	3	other	other	ADJ
gs-4321	126	4	extracellular	extracellular	ADJ
gs-4321	126	5	vesicles	vesicle	NOUN
gs-4321	126	6	represent	represent	VERB
gs-4321	126	7	another	another	DET
gs-4321	126	8	critical	critical	ADJ
gs-4321	126	9	dimension	dimension	NOUN
gs-4321	126	10	of	of	ADP
gs-4321	126	11	tme	tme	X
gs-4321	126	12	biology	biology	NOUN
gs-4321	126	13	.	.	PUNCT
gs-4321	127	1	these	these	DET
gs-4321	127	2	nanoscale	nanoscale	NOUN
gs-4321	127	3	vesicles	vesicle	NOUN
gs-4321	127	4	transport	transport	VERB
gs-4321	127	5	rna	rna	PROPN
gs-4321	127	6	,	,	PUNCT
gs-4321	127	7	dna	dna	PROPN
gs-4321	127	8	fragments	fragment	NOUN
gs-4321	127	9	,	,	PUNCT
gs-4321	127	10	proteins	protein	NOUN
gs-4321	127	11	,	,	PUNCT
gs-4321	127	12	lipids	lipid	NOUN
gs-4321	127	13	,	,	PUNCT
gs-4321	127	14	and	and	CCONJ
gs-4321	127	15	metabolites	metabolite	NOUN
gs-4321	127	16	between	between	ADP
gs-4321	127	17	cells	cell	NOUN
gs-4321	127	18	,	,	PUNCT
gs-4321	127	19	thereby	thereby	ADV
gs-4321	127	20	mediating	mediate	VERB
gs-4321	127	21	long	long	ADJ
gs-4321	127	22	-	-	PUNCT
gs-4321	127	23	distance	distance	NOUN
gs-4321	127	24	communication	communication	NOUN
gs-4321	127	25	within	within	ADP
gs-4321	127	26	the	the	DET
gs-4321	127	27	tumor	tumor	NOUN
gs-4321	127	28	ecosystem	ecosystem	NOUN
gs-4321	127	29	.	.	PUNCT
gs-4321	128	1	exosome	exosome	PROPN
gs-4321	128	2	profiling	profiling	NOUN
gs-4321	128	3	has	have	AUX
gs-4321	128	4	revealed	reveal	VERB
gs-4321	128	5	their	their	PRON
gs-4321	128	6	role	role	NOUN
gs-4321	128	7	in	in	ADP
gs-4321	128	8	metastatic	metastatic	ADJ
gs-4321	128	9	niche	niche	NOUN
gs-4321	128	10	formation	formation	NOUN
gs-4321	128	11	,	,	PUNCT
gs-4321	128	12	therapy	therapy	NOUN
gs-4321	128	13	resistance	resistance	NOUN
gs-4321	128	14	,	,	PUNCT
gs-4321	128	15	immune	immune	ADJ
gs-4321	128	16	modulation	modulation	NOUN
gs-4321	128	17	,	,	PUNCT
gs-4321	128	18	and	and	CCONJ
gs-4321	128	19	the	the	DET
gs-4321	128	20	dissemination	dissemination	NOUN
gs-4321	128	21	of	of	ADP
gs-4321	128	22	oncogenic	oncogenic	ADJ
gs-4321	128	23	signals	signal	NOUN
gs-4321	128	24	.	.	PUNCT
gs-4321	129	1	as	as	ADV
gs-4321	129	2	stable	stable	ADJ
gs-4321	129	3	and	and	CCONJ
gs-4321	129	4	easily	easily	ADV
gs-4321	129	5	accessible	accessible	ADJ
gs-4321	129	6	biomarkers	biomarker	NOUN
gs-4321	129	7	from	from	ADP
gs-4321	129	8	blood	blood	NOUN
gs-4321	129	9	or	or	CCONJ
gs-4321	129	10	other	other	ADJ
gs-4321	129	11	biofluids	biofluid	NOUN
gs-4321	129	12	,	,	PUNCT
gs-4321	129	13	exosomes	exosome	NOUN
gs-4321	129	14	also	also	ADV
gs-4321	129	15	offer	offer	VERB
gs-4321	129	16	tremendous	tremendous	ADJ
gs-4321	129	17	potential	potential	NOUN
gs-4321	129	18	for	for	ADP
gs-4321	129	19	non	non	ADJ
gs-4321	129	20	-	-	ADJ
gs-4321	129	21	invasive	invasive	ADJ
gs-4321	129	22	diagnostics	diagnostic	NOUN
gs-4321	129	23	and	and	CCONJ
gs-4321	129	24	therapeutic	therapeutic	ADJ
gs-4321	129	25	monitoring	monitoring	NOUN
gs-4321	129	26	.	.	PUNCT
gs-4321	130	1	immune	immune	ADJ
gs-4321	130	2	signaling	signal	VERB
gs-4321	130	3	networks	network	NOUN
gs-4321	130	4	within	within	ADP
gs-4321	130	5	the	the	DET
gs-4321	130	6	tme	tme	NOUN
gs-4321	130	7	have	have	AUX
gs-4321	130	8	received	receive	VERB
gs-4321	130	9	intense	intense	ADJ
gs-4321	130	10	scientific	scientific	ADJ
gs-4321	130	11	attention	attention	NOUN
gs-4321	130	12	due	due	ADP
gs-4321	130	13	to	to	ADP
gs-4321	130	14	their	their	PRON
gs-4321	130	15	central	central	ADJ
gs-4321	130	16	importance	importance	NOUN
gs-4321	130	17	in	in	ADP
gs-4321	130	18	immuno	immuno	ADJ
gs-4321	130	19	-	-	PUNCT
gs-4321	130	20	oncology	oncology	NOUN
gs-4321	130	21	.	.	PUNCT
gs-4321	131	1	tumors	tumor	NOUN
gs-4321	131	2	employ	employ	VERB
gs-4321	131	3	diverse	diverse	ADJ
gs-4321	131	4	strategies	strategy	NOUN
gs-4321	131	5	to	to	PART
gs-4321	131	6	escape	escape	VERB
gs-4321	131	7	immune	immune	ADJ
gs-4321	131	8	detection	detection	NOUN
gs-4321	131	9	,	,	PUNCT
gs-4321	131	10	including	include	VERB
gs-4321	131	11	upregulation	upregulation	NOUN
gs-4321	131	12	of	of	ADP
gs-4321	131	13	immune	immune	ADJ
gs-4321	131	14	checkpoint	checkpoint	NOUN
gs-4321	131	15	proteins	protein	NOUN
gs-4321	131	16	,	,	PUNCT
gs-4321	131	17	recruitment	recruitment	NOUN
gs-4321	131	18	of	of	ADP
gs-4321	131	19	immunosuppressive	immunosuppressive	ADJ
gs-4321	131	20	cell	cell	NOUN
gs-4321	131	21	subsets	subset	NOUN
gs-4321	131	22	,	,	PUNCT
gs-4321	131	23	secretion	secretion	NOUN
gs-4321	131	24	of	of	ADP
gs-4321	131	25	anti	anti	ADJ
gs-4321	131	26	-	-	ADJ
gs-4321	131	27	inflammatory	inflammatory	ADJ
gs-4321	131	28	cytokines	cytokine	NOUN
gs-4321	131	29	,	,	PUNCT
gs-4321	131	30	georgian	georgian	NOUN
gs-4321	131	31	scientists/	scientists/	NUM
gs-4321	131	32	.	.	PUNCT
gs-4321	132	1	7	7	NUM
gs-4321	132	2	n	n	DET
gs-4321	132	3	4	4	NUM
gs-4321	132	4	,	,	PUNCT
gs-4321	132	5	2025	2025	NUM
gs-4321	132	6	341	341	NUM
gs-4321	132	7	and	and	CCONJ
gs-4321	132	8	metabolic	metabolic	NOUN
gs-4321	132	9	suppression	suppression	NOUN
gs-4321	132	10	of	of	ADP
gs-4321	132	11	t	t	PROPN
gs-4321	132	12	-	-	PUNCT
gs-4321	132	13	cell	cell	NOUN
gs-4321	132	14	function	function	NOUN
gs-4321	132	15	.	.	PUNCT
gs-4321	133	1	multi	multi	ADJ
gs-4321	133	2	-	-	ADJ
gs-4321	133	3	omics	omics	ADJ
gs-4321	133	4	analysis	analysis	NOUN
gs-4321	133	5	of	of	ADP
gs-4321	133	6	immune	immune	ADJ
gs-4321	133	7	signaling	signal	VERB
gs-4321	133	8	pathways	pathway	NOUN
gs-4321	133	9	helps	help	VERB
gs-4321	133	10	decode	decode	VERB
gs-4321	133	11	these	these	DET
gs-4321	133	12	mechanisms	mechanism	NOUN
gs-4321	133	13	and	and	CCONJ
gs-4321	133	14	contributes	contribute	VERB
gs-4321	133	15	to	to	ADP
gs-4321	133	16	the	the	DET
gs-4321	133	17	development	development	NOUN
gs-4321	133	18	of	of	ADP
gs-4321	133	19	personalized	personalized	ADJ
gs-4321	133	20	immunotherapies	immunotherapy	NOUN
gs-4321	133	21	,	,	PUNCT
gs-4321	133	22	predictive	predictive	ADJ
gs-4321	133	23	biomarkers	biomarker	NOUN
gs-4321	133	24	,	,	PUNCT
gs-4321	133	25	and	and	CCONJ
gs-4321	133	26	strategies	strategy	NOUN
gs-4321	133	27	to	to	PART
gs-4321	133	28	overcome	overcome	VERB
gs-4321	133	29	therapeutic	therapeutic	ADJ
gs-4321	133	30	resistance	resistance	NOUN
gs-4321	133	31	.	.	PUNCT
gs-4321	134	1	integrating	integrate	VERB
gs-4321	134	2	multi	multi	ADJ
gs-4321	134	3	-	-	ADJ
gs-4321	134	4	omics	omics	ADJ
gs-4321	134	5	datasets	dataset	NOUN
gs-4321	134	6	requires	require	VERB
gs-4321	134	7	advanced	advanced	ADJ
gs-4321	134	8	bioinformatics	bioinformatics	NOUN
gs-4321	134	9	approaches	approach	NOUN
gs-4321	134	10	capable	capable	ADJ
gs-4321	134	11	of	of	ADP
gs-4321	134	12	managing	manage	VERB
gs-4321	134	13	high	high	ADJ
gs-4321	134	14	-	-	PUNCT
gs-4321	134	15	dimensional	dimensional	ADJ
gs-4321	134	16	data	datum	NOUN
gs-4321	134	17	,	,	PUNCT
gs-4321	134	18	performing	perform	VERB
gs-4321	134	19	multimodal	multimodal	NOUN
gs-4321	134	20	correlation	correlation	NOUN
gs-4321	134	21	analyses	analysis	NOUN
gs-4321	134	22	,	,	PUNCT
gs-4321	134	23	and	and	CCONJ
gs-4321	134	24	extracting	extract	VERB
gs-4321	134	25	biologically	biologically	ADV
gs-4321	134	26	meaningful	meaningful	ADJ
gs-4321	134	27	patterns	pattern	NOUN
gs-4321	134	28	.	.	PUNCT
gs-4321	135	1	emerging	emerge	VERB
gs-4321	135	2	computational	computational	ADJ
gs-4321	135	3	frameworks	framework	NOUN
gs-4321	135	4	—	—	PUNCT
gs-4321	135	5	including	include	VERB
gs-4321	135	6	machine	machine	NOUN
gs-4321	135	7	learning	learning	NOUN
gs-4321	135	8	,	,	PUNCT
gs-4321	135	9	network	network	NOUN
gs-4321	135	10	biology	biology	NOUN
gs-4321	135	11	,	,	PUNCT
gs-4321	135	12	pathway	pathway	NOUN
gs-4321	135	13	enrichment	enrichment	NOUN
gs-4321	135	14	modeling	modeling	NOUN
gs-4321	135	15	,	,	PUNCT
gs-4321	135	16	and	and	CCONJ
gs-4321	135	17	data	datum	NOUN
gs-4321	135	18	harmonization	harmonization	NOUN
gs-4321	135	19	techniques	technique	NOUN
gs-4321	135	20	—	—	PUNCT
gs-4321	135	21	are	be	AUX
gs-4321	135	22	revolutionizing	revolutionize	VERB
gs-4321	135	23	how	how	SCONJ
gs-4321	135	24	researchers	researcher	NOUN
gs-4321	135	25	decipher	decipher	VERB
gs-4321	135	26	complex	complex	ADJ
gs-4321	135	27	tme	tme	NOUN
gs-4321	135	28	interactions	interaction	NOUN
gs-4321	135	29	.	.	PUNCT
gs-4321	136	1	these	these	DET
gs-4321	136	2	integrative	integrative	ADJ
gs-4321	136	3	strategies	strategy	NOUN
gs-4321	136	4	enable	enable	VERB
gs-4321	136	5	scientists	scientist	NOUN
gs-4321	136	6	to	to	PART
gs-4321	136	7	map	map	VERB
gs-4321	136	8	intercellular	intercellular	ADJ
gs-4321	136	9	communication	communication	NOUN
gs-4321	136	10	networks	network	NOUN
gs-4321	136	11	,	,	PUNCT
gs-4321	136	12	identify	identify	VERB
gs-4321	136	13	regulatory	regulatory	ADJ
gs-4321	136	14	hubs	hub	NOUN
gs-4321	136	15	,	,	PUNCT
gs-4321	136	16	and	and	CCONJ
gs-4321	136	17	discover	discover	VERB
gs-4321	136	18	novel	novel	ADJ
gs-4321	136	19	therapeutic	therapeutic	ADJ
gs-4321	136	20	vulnerabilities	vulnerability	NOUN
gs-4321	136	21	.	.	PUNCT
gs-4321	137	1	collectively	collectively	ADV
gs-4321	137	2	,	,	PUNCT
gs-4321	137	3	multi	multi	ADJ
gs-4321	137	4	-	-	ADJ
gs-4321	137	5	omics	omics	ADJ
gs-4321	137	6	integration	integration	NOUN
gs-4321	137	7	—	—	PUNCT
gs-4321	137	8	supported	support	VERB
gs-4321	137	9	by	by	ADP
gs-4321	137	10	robust	robust	ADJ
gs-4321	137	11	bioinformatics	bioinformatic	NOUN
gs-4321	137	12	pipelines	pipeline	NOUN
gs-4321	137	13	—	—	PUNCT
gs-4321	137	14	provides	provide	VERB
gs-4321	137	15	a	a	DET
gs-4321	137	16	powerful	powerful	ADJ
gs-4321	137	17	lens	lens	NOUN
gs-4321	137	18	through	through	ADP
gs-4321	137	19	which	which	PRON
gs-4321	137	20	the	the	DET
gs-4321	137	21	intricate	intricate	ADJ
gs-4321	137	22	landscape	landscape	NOUN
gs-4321	137	23	of	of	ADP
gs-4321	137	24	the	the	DET
gs-4321	137	25	tumor	tumor	NOUN
gs-4321	137	26	microenvironment	microenvironment	NOUN
gs-4321	137	27	can	can	AUX
gs-4321	137	28	be	be	AUX
gs-4321	137	29	systematically	systematically	ADV
gs-4321	137	30	explored	explore	VERB
gs-4321	137	31	.	.	PUNCT
gs-4321	138	1	by	by	ADP
gs-4321	138	2	combining	combine	VERB
gs-4321	138	3	proteomic	proteomic	ADJ
gs-4321	138	4	signatures	signature	NOUN
gs-4321	138	5	,	,	PUNCT
gs-4321	138	6	exosomal	exosomal	ADJ
gs-4321	138	7	communication	communication	NOUN
gs-4321	138	8	patterns	pattern	NOUN
gs-4321	138	9	,	,	PUNCT
gs-4321	138	10	and	and	CCONJ
gs-4321	138	11	immune	immune	ADJ
gs-4321	138	12	signaling	signal	VERB
gs-4321	138	13	dynamics	dynamic	NOUN
gs-4321	138	14	,	,	PUNCT
gs-4321	138	15	researchers	researcher	NOUN
gs-4321	138	16	can	can	AUX
gs-4321	138	17	uncover	uncover	VERB
gs-4321	138	18	a	a	DET
gs-4321	138	19	more	more	ADV
gs-4321	138	20	complete	complete	ADJ
gs-4321	138	21	molecular	molecular	ADJ
gs-4321	138	22	portrait	portrait	NOUN
gs-4321	138	23	of	of	ADP
gs-4321	138	24	cancer	cancer	NOUN
gs-4321	138	25	biology	biology	NOUN
gs-4321	138	26	.	.	PUNCT
gs-4321	139	1	this	this	DET
gs-4321	139	2	integrative	integrative	ADJ
gs-4321	139	3	perspective	perspective	NOUN
gs-4321	139	4	is	be	AUX
gs-4321	139	5	essential	essential	ADJ
gs-4321	139	6	for	for	ADP
gs-4321	139	7	advancing	advance	VERB
gs-4321	139	8	precision	precision	NOUN
gs-4321	139	9	oncology	oncology	NOUN
gs-4321	139	10	,	,	PUNCT
gs-4321	139	11	improving	improve	VERB
gs-4321	139	12	early	early	ADJ
gs-4321	139	13	diagnosis	diagnosis	NOUN
gs-4321	139	14	,	,	PUNCT
gs-4321	139	15	monitoring	monitor	VERB
gs-4321	139	16	therapy	therapy	NOUN
gs-4321	139	17	response	response	NOUN
gs-4321	139	18	,	,	PUNCT
gs-4321	139	19	and	and	CCONJ
gs-4321	139	20	developing	develop	VERB
gs-4321	139	21	innovative	innovative	ADJ
gs-4321	139	22	targeted	target	VERB
gs-4321	139	23	and	and	CCONJ
gs-4321	139	24	immunotherapeutic	immunotherapeutic	ADJ
gs-4321	139	25	interventions	intervention	NOUN
gs-4321	139	26	.	.	PUNCT
gs-4321	140	1	while	while	SCONJ
gs-4321	140	2	transcriptional	transcriptional	ADJ
gs-4321	140	3	and	and	CCONJ
gs-4321	140	4	epigenomic	epigenomic	ADJ
gs-4321	140	5	profiling	profiling	NOUN
gs-4321	140	6	have	have	AUX
gs-4321	140	7	dominated	dominate	VERB
gs-4321	140	8	the	the	DET
gs-4321	140	9	single	single	ADJ
gs-4321	140	10	-	-	PUNCT
gs-4321	140	11	cell	cell	NOUN
gs-4321	140	12	landscape	landscape	NOUN
gs-4321	140	13	,	,	PUNCT
gs-4321	140	14	a	a	DET
gs-4321	140	15	critical	critical	ADJ
gs-4321	140	16	layer	layer	NOUN
gs-4321	140	17	of	of	ADP
gs-4321	140	18	regulation	regulation	NOUN
gs-4321	140	19	has	have	AUX
gs-4321	140	20	remained	remain	VERB
gs-4321	140	21	comparatively	comparatively	ADV
gs-4321	140	22	underexplored	underexplored	ADJ
gs-4321	140	23	:	:	PUNCT
gs-4321	140	24	the	the	DET
gs-4321	140	25	proteome	proteome	NOUN
gs-4321	140	26	.	.	PUNCT
gs-4321	141	1	proteins	protein	NOUN
gs-4321	141	2	are	be	AUX
gs-4321	141	3	the	the	DET
gs-4321	141	4	primary	primary	ADJ
gs-4321	141	5	functional	functional	ADJ
gs-4321	141	6	actors	actor	NOUN
gs-4321	141	7	within	within	ADP
gs-4321	141	8	the	the	DET
gs-4321	141	9	cell	cell	NOUN
gs-4321	141	10	,	,	PUNCT
gs-4321	141	11	governing	govern	VERB
gs-4321	141	12	signaling	signal	VERB
gs-4321	141	13	cascades	cascade	NOUN
gs-4321	141	14	,	,	PUNCT
gs-4321	141	15	metabolic	metabolic	NOUN
gs-4321	141	16	flux	flux	NOUN
gs-4321	141	17	,	,	PUNCT
gs-4321	141	18	and	and	CCONJ
gs-4321	141	19	structural	structural	ADJ
gs-4321	141	20	integrity	integrity	NOUN
gs-4321	141	21	.	.	PUNCT
gs-4321	142	1	post	post	ADJ
gs-4321	142	2	-	-	ADJ
gs-4321	142	3	transcriptional	transcriptional	ADJ
gs-4321	142	4	regulation	regulation	NOUN
gs-4321	142	5	means	mean	VERB
gs-4321	142	6	that	that	SCONJ
gs-4321	142	7	mrna	mrna	PROPN
gs-4321	142	8	levels	level	NOUN
gs-4321	142	9	often	often	ADV
gs-4321	142	10	poorly	poorly	ADV
gs-4321	142	11	predict	predict	VERB
gs-4321	142	12	protein	protein	NOUN
gs-4321	142	13	abundance	abundance	NOUN
gs-4321	142	14	or	or	CCONJ
gs-4321	142	15	activity	activity	NOUN
gs-4321	142	16	.	.	PUNCT
gs-4321	143	1	the	the	DET
gs-4321	143	2	emergence	emergence	NOUN
gs-4321	143	3	of	of	ADP
gs-4321	143	4	highdimensional	highdimensional	ADJ
gs-4321	143	5	single	single	ADJ
gs-4321	143	6	-	-	PUNCT
gs-4321	143	7	cell	cell	NOUN
gs-4321	143	8	proteomics	proteomic	NOUN
gs-4321	143	9	,	,	PUNCT
gs-4321	143	10	such	such	ADJ
gs-4321	143	11	as	as	ADP
gs-4321	143	12	mass	mass	NOUN
gs-4321	143	13	cytometry	cytometry	NOUN
gs-4321	143	14	(	(	PUNCT
gs-4321	143	15	cytof	cytof	PROPN
gs-4321	143	16	)	)	PUNCT
gs-4321	143	17	and	and	CCONJ
gs-4321	143	18	cite	cite	VERB
gs-4321	143	19	-	-	PUNCT
gs-4321	143	20	seq	seq	NOUN
gs-4321	143	21	,	,	PUNCT
gs-4321	143	22	now	now	ADV
gs-4321	143	23	allows	allow	VERB
gs-4321	143	24	for	for	ADP
gs-4321	143	25	the	the	DET
gs-4321	143	26	simultaneous	simultaneous	ADJ
gs-4321	143	27	quantification	quantification	NOUN
gs-4321	143	28	of	of	ADP
gs-4321	143	29	dozens	dozen	NOUN
gs-4321	143	30	of	of	ADP
gs-4321	143	31	surface	surface	NOUN
gs-4321	143	32	and	and	CCONJ
gs-4321	143	33	intracellular	intracellular	ADJ
gs-4321	143	34	proteins	protein	NOUN
gs-4321	143	35	alongside	alongside	ADP
gs-4321	143	36	the	the	DET
gs-4321	143	37	transcriptome	transcriptome	NOUN
gs-4321	143	38	.	.	PUNCT
gs-4321	144	1	this	this	DET
gs-4321	144	2	integration	integration	NOUN
gs-4321	144	3	is	be	AUX
gs-4321	144	4	vital	vital	ADJ
gs-4321	144	5	,	,	PUNCT
gs-4321	144	6	as	as	SCONJ
gs-4321	144	7	therapy	therapy	NOUN
gs-4321	144	8	-	-	PUNCT
gs-4321	144	9	resistant	resistant	ADJ
gs-4321	144	10	states	state	NOUN
gs-4321	144	11	are	be	AUX
gs-4321	144	12	frequently	frequently	ADV
gs-4321	144	13	defined	define	VERB
gs-4321	144	14	not	not	PART
gs-4321	144	15	by	by	ADP
gs-4321	144	16	transcriptional	transcriptional	ADJ
gs-4321	144	17	shifts	shift	NOUN
gs-4321	144	18	,	,	PUNCT
gs-4321	144	19	but	but	CCONJ
gs-4321	144	20	by	by	ADP
gs-4321	144	21	the	the	DET
gs-4321	144	22	activation	activation	NOUN
gs-4321	144	23	of	of	ADP
gs-4321	144	24	key	key	ADJ
gs-4321	144	25	survival	survival	NOUN
gs-4321	144	26	pathways	pathway	NOUN
gs-4321	144	27	like	like	ADP
gs-4321	144	28	pi3k	pi3k	PROPN
gs-4321	144	29	/	/	SYM
gs-4321	144	30	akt	akt	PROPN
gs-4321	144	31	and	and	CCONJ
gs-4321	144	32	mapk	mapk	NOUN
gs-4321	144	33	at	at	ADP
gs-4321	144	34	the	the	DET
gs-4321	144	35	protein	protein	NOUN
gs-4321	144	36	level	level	NOUN
gs-4321	144	37	.	.	PUNCT
gs-4321	145	1	a	a	DET
gs-4321	145	2	truly	truly	ADV
gs-4321	145	3	holistic	holistic	ADJ
gs-4321	145	4	model	model	NOUN
gs-4321	145	5	of	of	ADP
gs-4321	145	6	plasticity	plasticity	NOUN
gs-4321	145	7	must	must	AUX
gs-4321	145	8	therefore	therefore	ADV
gs-4321	145	9	fuse	fuse	VERB
gs-4321	145	10	proteogenomic	proteogenomic	ADJ
gs-4321	145	11	insights	insight	NOUN
gs-4321	145	12	to	to	PART
gs-4321	145	13	reveal	reveal	VERB
gs-4321	145	14	the	the	DET
gs-4321	145	15	functional	functional	ADJ
gs-4321	145	16	proteome	proteome	NOUN
gs-4321	145	17	that	that	PRON
gs-4321	145	18	ultimately	ultimately	ADV
gs-4321	145	19	executes	execute	VERB
gs-4321	145	20	adaptive	adaptive	ADJ
gs-4321	145	21	decisions	decision	NOUN
gs-4321	145	22	.	.	PUNCT
gs-4321	146	1	simultaneously	simultaneously	ADV
gs-4321	146	2	,	,	PUNCT
gs-4321	146	3	the	the	DET
gs-4321	146	4	role	role	NOUN
gs-4321	146	5	of	of	ADP
gs-4321	146	6	exosomes	exosome	NOUN
gs-4321	146	7	as	as	ADP
gs-4321	146	8	systemic	systemic	ADJ
gs-4321	146	9	orchestrators	orchestrator	NOUN
gs-4321	146	10	of	of	ADP
gs-4321	146	11	plasticity	plasticity	NOUN
gs-4321	146	12	has	have	AUX
gs-4321	146	13	gained	gain	VERB
gs-4321	146	14	prominence	prominence	NOUN
gs-4321	146	15	.	.	PUNCT
gs-4321	147	1	these	these	DET
gs-4321	147	2	extracellular	extracellular	ADJ
gs-4321	147	3	vesicles	vesicle	NOUN
gs-4321	147	4	facilitate	facilitate	VERB
gs-4321	147	5	a	a	DET
gs-4321	147	6	radical	radical	ADJ
gs-4321	147	7	form	form	NOUN
gs-4321	147	8	of	of	ADP
gs-4321	147	9	intercellular	intercellular	ADJ
gs-4321	147	10	communication	communication	NOUN
gs-4321	147	11	,	,	PUNCT
gs-4321	147	12	transferring	transfer	VERB
gs-4321	147	13	bioactive	bioactive	ADJ
gs-4321	147	14	cargo	cargo	NOUN
gs-4321	147	15	—	—	PUNCT
gs-4321	147	16	including	include	VERB
gs-4321	147	17	proteins	protein	NOUN
gs-4321	147	18	,	,	PUNCT
gs-4321	147	19	metabolites	metabolite	NOUN
gs-4321	147	20	,	,	PUNCT
gs-4321	147	21	and	and	CCONJ
gs-4321	147	22	regulatory	regulatory	ADJ
gs-4321	147	23	non	non	ADJ
gs-4321	147	24	-	-	ADJ
gs-4321	147	25	coding	coding	ADJ
gs-4321	147	26	rnas	rna	NOUN
gs-4321	147	27	—	—	PUNCT
gs-4321	147	28	across	across	ADP
gs-4321	147	29	significant	significant	ADJ
gs-4321	147	30	distances	distance	NOUN
gs-4321	147	31	within	within	ADP
gs-4321	147	32	the	the	DET
gs-4321	147	33	tme	tme	NOUN
gs-4321	147	34	.	.	PUNCT
gs-4321	148	1	a	a	DET
gs-4321	148	2	cancerassociated	cancerassociate	VERB
gs-4321	148	3	fibroblast	fibroblast	NOUN
gs-4321	148	4	can	can	AUX
gs-4321	148	5	dispatch	dispatch	VERB
gs-4321	148	6	exosomes	exosome	NOUN
gs-4321	148	7	containing	contain	VERB
gs-4321	148	8	tgf	tgf	PROPN
gs-4321	148	9	or	or	CCONJ
gs-4321	148	10	specific	specific	ADJ
gs-4321	148	11	micrornas	microrna	NOUN
gs-4321	148	12	that	that	PRON
gs-4321	148	13	directly	directly	ADV
gs-4321	148	14	reprogram	reprogram	VERB
gs-4321	148	15	a	a	DET
gs-4321	148	16	differentiated	differentiated	ADJ
gs-4321	148	17	cancer	cancer	NOUN
gs-4321	148	18	cell	cell	NOUN
gs-4321	148	19	into	into	ADP
gs-4321	148	20	a	a	DET
gs-4321	148	21	stem	stem	NOUN
gs-4321	148	22	-	-	PUNCT
gs-4321	148	23	like	like	ADJ
gs-4321	148	24	state	state	NOUN
gs-4321	148	25	.	.	PUNCT
gs-4321	149	1	immune	immune	ADJ
gs-4321	149	2	cells	cell	NOUN
gs-4321	149	3	can	can	AUX
gs-4321	149	4	georgian	georgian	VERB
gs-4321	149	5	scientists/	scientists/	NUM
gs-4321	149	6	.	.	PUNCT
gs-4321	150	1	7	7	NUM
gs-4321	150	2	n	n	DET
gs-4321	150	3	4	4	NUM
gs-4321	150	4	,	,	PUNCT
gs-4321	150	5	2025	2025	NUM
gs-4321	150	6	342	342	NUM
gs-4321	150	7	secrete	secrete	NOUN
gs-4321	150	8	vesicles	vesicle	NOUN
gs-4321	150	9	that	that	PRON
gs-4321	150	10	alter	alter	VERB
gs-4321	150	11	antigen	antigen	ADJ
gs-4321	150	12	presentation	presentation	NOUN
gs-4321	150	13	on	on	ADP
gs-4321	150	14	tumor	tumor	NOUN
gs-4321	150	15	cells	cell	NOUN
gs-4321	150	16	,	,	PUNCT
gs-4321	150	17	promoting	promote	VERB
gs-4321	150	18	immune	immune	ADJ
gs-4321	150	19	evasion	evasion	NOUN
gs-4321	150	20	.	.	PUNCT
gs-4321	151	1	this	this	DET
gs-4321	151	2	exosome	exosome	ADV
gs-4321	151	3	-	-	PUNCT
gs-4321	151	4	mediated	mediate	VERB
gs-4321	151	5	molecular	molecular	ADJ
gs-4321	151	6	exchange	exchange	NOUN
gs-4321	151	7	creates	create	VERB
gs-4321	151	8	a	a	DET
gs-4321	151	9	decentralized	decentralized	ADJ
gs-4321	151	10	regulatory	regulatory	ADJ
gs-4321	151	11	network	network	NOUN
gs-4321	151	12	that	that	PRON
gs-4321	151	13	amplifies	amplify	VERB
gs-4321	151	14	plasticity	plasticity	NOUN
gs-4321	151	15	beyond	beyond	ADP
gs-4321	151	16	the	the	DET
gs-4321	151	17	reach	reach	NOUN
gs-4321	151	18	of	of	ADP
gs-4321	151	19	direct	direct	ADJ
gs-4321	151	20	cell	cell	NOUN
gs-4321	151	21	-	-	PUNCT
gs-4321	151	22	cell	cell	NOUN
gs-4321	151	23	contact	contact	NOUN
gs-4321	151	24	.	.	PUNCT
gs-4321	152	1	integrating	integrate	VERB
gs-4321	152	2	exosomal	exosomal	ADJ
gs-4321	152	3	cargo	cargo	NOUN
gs-4321	152	4	data	datum	NOUN
gs-4321	152	5	with	with	ADP
gs-4321	152	6	single	single	ADJ
gs-4321	152	7	-	-	PUNCT
gs-4321	152	8	cell	cell	NOUN
gs-4321	152	9	transcriptomics	transcriptomic	NOUN
gs-4321	152	10	from	from	ADP
gs-4321	152	11	the	the	DET
gs-4321	152	12	same	same	ADJ
gs-4321	152	13	tumor	tumor	NOUN
gs-4321	152	14	sample	sample	NOUN
gs-4321	152	15	presents	present	VERB
gs-4321	152	16	an	an	DET
gs-4321	152	17	emerging	emerge	VERB
gs-4321	152	18	frontier	frontier	NOUN
gs-4321	152	19	,	,	PUNCT
gs-4321	152	20	allowing	allow	VERB
gs-4321	152	21	researchers	researcher	NOUN
gs-4321	152	22	to	to	PART
gs-4321	152	23	map	map	VERB
gs-4321	152	24	these	these	DET
gs-4321	152	25	functional	functional	ADJ
gs-4321	152	26	"	"	PUNCT
gs-4321	152	27	supply	supply	NOUN
gs-4321	152	28	lines	line	NOUN
gs-4321	152	29	"	"	PUNCT
gs-4321	152	30	and	and	CCONJ
gs-4321	152	31	identify	identify	VERB
gs-4321	152	32	the	the	DET
gs-4321	152	33	vesicle	vesicle	NOUN
gs-4321	152	34	-	-	PUNCT
gs-4321	152	35	derived	derive	VERB
gs-4321	152	36	molecules	molecule	NOUN
gs-4321	152	37	that	that	PRON
gs-4321	152	38	are	be	AUX
gs-4321	152	39	master	master	NOUN
gs-4321	152	40	regulators	regulator	NOUN
gs-4321	152	41	of	of	ADP
gs-4321	152	42	state	state	NOUN
gs-4321	152	43	interconversion	interconversion	NOUN
gs-4321	152	44	.	.	PUNCT
gs-4321	153	1	understanding	understand	VERB
gs-4321	153	2	this	this	DET
gs-4321	153	3	dialogue	dialogue	NOUN
gs-4321	153	4	is	be	AUX
gs-4321	153	5	key	key	ADJ
gs-4321	153	6	to	to	ADP
gs-4321	153	7	disrupting	disrupt	VERB
gs-4321	153	8	the	the	DET
gs-4321	153	9	systemic	systemic	ADJ
gs-4321	153	10	signals	signal	NOUN
gs-4321	153	11	that	that	PRON
gs-4321	153	12	maintain	maintain	VERB
gs-4321	153	13	tumor	tumor	NOUN
gs-4321	153	14	adaptability	adaptability	NOUN
gs-4321	153	15	.	.	PUNCT
gs-4321	154	1	microenvironmental	microenvironmental	ADJ
gs-4321	154	2	regulation	regulation	NOUN
gs-4321	154	3	of	of	ADP
gs-4321	154	4	phenotypic	phenotypic	ADJ
gs-4321	154	5	transitions	transition	NOUN
gs-4321	154	6	the	the	DET
gs-4321	154	7	interplay	interplay	NOUN
gs-4321	154	8	between	between	ADP
gs-4321	154	9	malignant	malignant	ADJ
gs-4321	154	10	cells	cell	NOUN
gs-4321	154	11	and	and	CCONJ
gs-4321	154	12	their	their	PRON
gs-4321	154	13	surrounding	surround	VERB
gs-4321	154	14	microenvironment	microenvironment	NOUN
gs-4321	154	15	is	be	AUX
gs-4321	154	16	a	a	DET
gs-4321	154	17	fundamental	fundamental	ADJ
gs-4321	154	18	determinant	determinant	NOUN
gs-4321	154	19	of	of	ADP
gs-4321	154	20	phenotypic	phenotypic	ADJ
gs-4321	154	21	plasticity	plasticity	NOUN
gs-4321	154	22	.	.	PUNCT
gs-4321	155	1	tumors	tumor	NOUN
gs-4321	155	2	represent	represent	VERB
gs-4321	155	3	highly	highly	ADV
gs-4321	155	4	dynamic	dynamic	ADJ
gs-4321	155	5	ecosystems	ecosystem	NOUN
gs-4321	155	6	where	where	SCONJ
gs-4321	155	7	cancer	cancer	NOUN
gs-4321	155	8	cells	cell	NOUN
gs-4321	155	9	constantly	constantly	ADV
gs-4321	155	10	integrate	integrate	VERB
gs-4321	155	11	signals	signal	NOUN
gs-4321	155	12	from	from	ADP
gs-4321	155	13	stromal	stromal	ADJ
gs-4321	155	14	fibroblasts	fibroblast	NOUN
gs-4321	155	15	,	,	PUNCT
gs-4321	155	16	endothelial	endothelial	ADJ
gs-4321	155	17	cells	cell	NOUN
gs-4321	155	18	,	,	PUNCT
gs-4321	155	19	infiltrating	infiltrating	ADJ
gs-4321	155	20	immune	immune	ADJ
gs-4321	155	21	populations	population	NOUN
gs-4321	155	22	,	,	PUNCT
gs-4321	155	23	extracellular	extracellular	ADJ
gs-4321	155	24	matrix	matrix	NOUN
gs-4321	155	25	components	component	NOUN
gs-4321	155	26	,	,	PUNCT
gs-4321	155	27	and	and	CCONJ
gs-4321	155	28	soluble	soluble	ADJ
gs-4321	155	29	mediators	mediator	NOUN
gs-4321	155	30	such	such	ADJ
gs-4321	155	31	as	as	ADP
gs-4321	155	32	cytokines	cytokine	NOUN
gs-4321	155	33	and	and	CCONJ
gs-4321	155	34	growth	growth	NOUN
gs-4321	155	35	factors	factor	NOUN
gs-4321	155	36	.	.	PUNCT
gs-4321	156	1	these	these	DET
gs-4321	156	2	interactions	interaction	NOUN
gs-4321	156	3	influence	influence	VERB
gs-4321	156	4	lineage	lineage	NOUN
gs-4321	156	5	commitment	commitment	NOUN
gs-4321	156	6	,	,	PUNCT
gs-4321	156	7	stem	stem	NOUN
gs-4321	156	8	-	-	PUNCT
gs-4321	156	9	like	like	ADJ
gs-4321	156	10	reprogramming	reprogramme	VERB
gs-4321	156	11	,	,	PUNCT
gs-4321	156	12	and	and	CCONJ
gs-4321	156	13	survival	survival	NOUN
gs-4321	156	14	responses	response	NOUN
gs-4321	156	15	under	under	ADP
gs-4321	156	16	stress	stress	NOUN
gs-4321	156	17	.	.	PUNCT
gs-4321	157	1	crosstalk	crosstalk	NOUN
gs-4321	157	2	mediated	mediate	VERB
gs-4321	157	3	by	by	ADP
gs-4321	157	4	tgf	tgf	PROPN
gs-4321	157	5	,	,	PUNCT
gs-4321	157	6	il-6	il-6	NOUN
gs-4321	157	7	,	,	PUNCT
gs-4321	157	8	cxcl12	cxcl12	ADJ
gs-4321	157	9	,	,	PUNCT
gs-4321	157	10	and	and	CCONJ
gs-4321	157	11	wnt	wnt	PROPN
gs-4321	157	12	ligands	ligand	NOUN
gs-4321	157	13	has	have	AUX
gs-4321	157	14	been	be	AUX
gs-4321	157	15	repeatedly	repeatedly	ADV
gs-4321	157	16	implicated	implicate	VERB
gs-4321	157	17	in	in	ADP
gs-4321	157	18	driving	drive	VERB
gs-4321	157	19	stem	stem	NOUN
gs-4321	157	20	-	-	PUNCT
gs-4321	157	21	associated	associate	VERB
gs-4321	157	22	states	state	NOUN
gs-4321	157	23	across	across	ADP
gs-4321	157	24	a	a	DET
gs-4321	157	25	broad	broad	ADJ
gs-4321	157	26	spectrum	spectrum	NOUN
gs-4321	157	27	of	of	ADP
gs-4321	157	28	cancers	cancer	NOUN
gs-4321	157	29	(	(	PUNCT
gs-4321	157	30	ogden	ogden	PROPN
gs-4321	157	31	et	et	PROPN
gs-4321	157	32	al	al	PROPN
gs-4321	157	33	.	.	PROPN
gs-4321	157	34	,	,	PUNCT
gs-4321	157	35	2020	2020	NUM
gs-4321	157	36	;	;	PUNCT
gs-4321	157	37	lamouille	lamouille	NOUN
gs-4321	157	38	et	et	PROPN
gs-4321	157	39	al	al	PROPN
gs-4321	157	40	.	.	PROPN
gs-4321	157	41	,	,	PUNCT
gs-4321	157	42	2014	2014	NUM
gs-4321	157	43	)	)	PUNCT
gs-4321	157	44	.	.	PUNCT
gs-4321	158	1	computational	computational	ADJ
gs-4321	158	2	tools	tool	NOUN
gs-4321	158	3	that	that	PRON
gs-4321	158	4	infer	infer	VERB
gs-4321	158	5	ligand	ligand	NOUN
gs-4321	158	6	–	–	PUNCT
gs-4321	158	7	receptor	receptor	NOUN
gs-4321	158	8	interactions	interaction	NOUN
gs-4321	158	9	from	from	ADP
gs-4321	158	10	single	single	ADJ
gs-4321	158	11	-	-	PUNCT
gs-4321	158	12	cell	cell	NOUN
gs-4321	158	13	data	datum	NOUN
gs-4321	158	14	have	have	AUX
gs-4321	158	15	provided	provide	VERB
gs-4321	158	16	compelling	compelling	ADJ
gs-4321	158	17	evidence	evidence	NOUN
gs-4321	158	18	that	that	SCONJ
gs-4321	158	19	bidirectional	bidirectional	ADJ
gs-4321	158	20	signaling	signal	VERB
gs-4321	158	21	networks	network	NOUN
gs-4321	158	22	orchestrate	orchestrate	VERB
gs-4321	158	23	these	these	DET
gs-4321	158	24	transitions	transition	NOUN
gs-4321	158	25	in	in	ADP
gs-4321	158	26	a	a	DET
gs-4321	158	27	context	context	NOUN
gs-4321	158	28	-	-	PUNCT
gs-4321	158	29	dependent	dependent	ADJ
gs-4321	158	30	manner	manner	NOUN
gs-4321	158	31	.	.	PUNCT
gs-4321	159	1	stromal	stromal	ADJ
gs-4321	159	2	and	and	CCONJ
gs-4321	159	3	immune	immune	ADJ
gs-4321	159	4	components	component	NOUN
gs-4321	159	5	as	as	ADP
gs-4321	159	6	plasticity	plasticity	NOUN
gs-4321	159	7	modulators	modulator	NOUN
gs-4321	159	8	fibroblasts	fibroblast	NOUN
gs-4321	159	9	within	within	ADP
gs-4321	159	10	the	the	DET
gs-4321	159	11	tumor	tumor	NOUN
gs-4321	159	12	stroma	stroma	NOUN
gs-4321	159	13	can	can	AUX
gs-4321	159	14	adopt	adopt	VERB
gs-4321	159	15	activated	activated	ADJ
gs-4321	159	16	states	state	NOUN
gs-4321	159	17	characterized	characterize	VERB
gs-4321	159	18	by	by	ADP
gs-4321	159	19	secretion	secretion	NOUN
gs-4321	159	20	of	of	ADP
gs-4321	159	21	extracellular	extracellular	ADJ
gs-4321	159	22	matrix	matrix	NOUN
gs-4321	159	23	proteins	protein	NOUN
gs-4321	159	24	,	,	PUNCT
gs-4321	159	25	remodeling	remodeling	NOUN
gs-4321	159	26	enzymes	enzyme	NOUN
gs-4321	159	27	,	,	PUNCT
gs-4321	159	28	and	and	CCONJ
gs-4321	159	29	pro	pro	ADJ
gs-4321	159	30	-	-	ADJ
gs-4321	159	31	inflammatory	inflammatory	ADJ
gs-4321	159	32	mediators	mediator	NOUN
gs-4321	159	33	.	.	PUNCT
gs-4321	160	1	these	these	DET
gs-4321	160	2	cancer	cancer	NOUN
gs-4321	160	3	-	-	PUNCT
gs-4321	160	4	associated	associate	VERB
gs-4321	160	5	fibroblasts	fibroblast	NOUN
gs-4321	160	6	are	be	AUX
gs-4321	160	7	increasingly	increasingly	ADV
gs-4321	160	8	recognized	recognize	VERB
gs-4321	160	9	as	as	ADP
gs-4321	160	10	powerful	powerful	ADJ
gs-4321	160	11	regulators	regulator	NOUN
gs-4321	160	12	of	of	ADP
gs-4321	160	13	cellular	cellular	ADJ
gs-4321	160	14	heterogeneity	heterogeneity	NOUN
gs-4321	160	15	by	by	ADP
gs-4321	160	16	establishing	establish	VERB
gs-4321	160	17	physical	physical	ADJ
gs-4321	160	18	and	and	CCONJ
gs-4321	160	19	biochemical	biochemical	ADJ
gs-4321	160	20	niches	niche	NOUN
gs-4321	160	21	that	that	PRON
gs-4321	160	22	promote	promote	VERB
gs-4321	160	23	adaptive	adaptive	ADJ
gs-4321	160	24	transcriptional	transcriptional	NOUN
gs-4321	160	25	programs	program	NOUN
gs-4321	160	26	(	(	PUNCT
gs-4321	160	27	kalluri	kalluri	PROPN
gs-4321	160	28	,	,	PUNCT
gs-4321	160	29	2016	2016	NUM
gs-4321	160	30	)	)	PUNCT
gs-4321	160	31	.	.	PUNCT
gs-4321	161	1	immune	immune	ADJ
gs-4321	161	2	cells	cell	NOUN
gs-4321	161	3	—	—	PUNCT
gs-4321	161	4	particularly	particularly	ADV
gs-4321	161	5	macrophages	macrophage	NOUN
gs-4321	161	6	and	and	CCONJ
gs-4321	161	7	t	t	NOUN
gs-4321	161	8	cells	cell	NOUN
gs-4321	161	9	—	—	PUNCT
gs-4321	161	10	also	also	ADV
gs-4321	161	11	contribute	contribute	VERB
gs-4321	161	12	to	to	ADP
gs-4321	161	13	the	the	DET
gs-4321	161	14	emergence	emergence	NOUN
gs-4321	161	15	of	of	ADP
gs-4321	161	16	stem	stem	NOUN
gs-4321	161	17	-	-	PUNCT
gs-4321	161	18	like	like	ADJ
gs-4321	161	19	phenotypes	phenotype	NOUN
gs-4321	161	20	.	.	PUNCT
gs-4321	162	1	macrophagederived	macrophagederive	VERB
gs-4321	162	2	cytokines	cytokine	NOUN
gs-4321	162	3	can	can	AUX
gs-4321	162	4	enhance	enhance	VERB
gs-4321	162	5	survival	survival	NOUN
gs-4321	162	6	pathways	pathway	NOUN
gs-4321	162	7	and	and	CCONJ
gs-4321	162	8	support	support	VERB
gs-4321	162	9	dedifferentiation	dedifferentiation	NOUN
gs-4321	162	10	,	,	PUNCT
gs-4321	162	11	while	while	SCONJ
gs-4321	162	12	tcell	tcell	NOUN
gs-4321	162	13	–	–	PUNCT
gs-4321	162	14	derived	derive	VERB
gs-4321	162	15	signals	signal	NOUN
gs-4321	162	16	may	may	AUX
gs-4321	162	17	promote	promote	VERB
gs-4321	162	18	resistance	resistance	NOUN
gs-4321	162	19	-	-	PUNCT
gs-4321	162	20	associated	associate	VERB
gs-4321	162	21	states	state	NOUN
gs-4321	162	22	following	follow	VERB
gs-4321	162	23	therapy	therapy	NOUN
gs-4321	162	24	(	(	PUNCT
gs-4321	162	25	cassetta	cassetta	NOUN
gs-4321	162	26	and	and	CCONJ
gs-4321	162	27	pollard	pollard	NOUN
gs-4321	162	28	,	,	PUNCT
gs-4321	162	29	2020	2020	NUM
gs-4321	162	30	;	;	PUNCT
gs-4321	162	31	jerby	jerby	NOUN
gs-4321	162	32	-	-	PUNCT
gs-4321	162	33	arnon	arnon	PROPN
gs-4321	162	34	et	et	PROPN
gs-4321	162	35	al	al	PROPN
gs-4321	162	36	.	.	PROPN
gs-4321	162	37	,	,	PUNCT
gs-4321	162	38	2018	2018	NUM
gs-4321	162	39	)	)	PUNCT
gs-4321	162	40	.	.	PUNCT
gs-4321	163	1	single	single	ADJ
gs-4321	163	2	-	-	PUNCT
gs-4321	163	3	cell	cell	NOUN
gs-4321	163	4	analytical	analytical	ADJ
gs-4321	163	5	pipelines	pipeline	NOUN
gs-4321	163	6	integrating	integrate	VERB
gs-4321	163	7	immune	immune	ADJ
gs-4321	163	8	profiling	profiling	NOUN
gs-4321	163	9	with	with	ADP
gs-4321	163	10	malignant	malignant	ADJ
gs-4321	163	11	cell	cell	NOUN
gs-4321	163	12	states	state	NOUN
gs-4321	163	13	have	have	AUX
gs-4321	163	14	revealed	reveal	VERB
gs-4321	163	15	that	that	SCONJ
gs-4321	163	16	plasticity	plasticity	NOUN
gs-4321	163	17	often	often	ADV
gs-4321	163	18	arises	arise	VERB
gs-4321	163	19	through	through	ADP
gs-4321	163	20	coordinated	coordinated	ADJ
gs-4321	163	21	changes	change	NOUN
gs-4321	163	22	in	in	ADP
gs-4321	163	23	multiple	multiple	ADJ
gs-4321	163	24	cellular	cellular	ADJ
gs-4321	163	25	compartments	compartment	NOUN
gs-4321	163	26	,	,	PUNCT
gs-4321	163	27	rather	rather	ADV
gs-4321	163	28	than	than	ADP
gs-4321	163	29	being	be	AUX
gs-4321	163	30	restricted	restrict	VERB
gs-4321	163	31	to	to	ADP
gs-4321	163	32	tumor	tumor	NOUN
gs-4321	163	33	cells	cell	NOUN
gs-4321	163	34	alone	alone	ADV
gs-4321	163	35	.	.	PUNCT
gs-4321	164	1	extracellular	extracellular	ADJ
gs-4321	164	2	vesicles	vesicle	NOUN
gs-4321	164	3	as	as	ADP
gs-4321	164	4	drivers	driver	NOUN
gs-4321	164	5	of	of	ADP
gs-4321	164	6	state	state	NOUN
gs-4321	164	7	interconversion	interconversion	NOUN
gs-4321	164	8	another	another	DET
gs-4321	164	9	key	key	ADJ
gs-4321	164	10	layer	layer	NOUN
gs-4321	164	11	of	of	ADP
gs-4321	164	12	regulation	regulation	NOUN
gs-4321	164	13	involves	involve	VERB
gs-4321	164	14	extracellular	extracellular	ADJ
gs-4321	164	15	vesicles	vesicle	NOUN
gs-4321	164	16	,	,	PUNCT
gs-4321	164	17	including	include	VERB
gs-4321	164	18	exosomes	exosome	NOUN
gs-4321	164	19	,	,	PUNCT
gs-4321	164	20	which	which	PRON
gs-4321	164	21	transfer	transfer	VERB
gs-4321	164	22	proteins	protein	NOUN
gs-4321	164	23	,	,	PUNCT
gs-4321	164	24	lipids	lipid	NOUN
gs-4321	164	25	,	,	PUNCT
gs-4321	164	26	and	and	CCONJ
gs-4321	164	27	nucleic	nucleic	ADJ
gs-4321	164	28	acids	acid	NOUN
gs-4321	164	29	between	between	ADP
gs-4321	164	30	cells	cell	NOUN
gs-4321	164	31	.	.	PUNCT
gs-4321	165	1	single	single	ADJ
gs-4321	165	2	-	-	PUNCT
gs-4321	165	3	cell	cell	NOUN
gs-4321	165	4	–	–	PUNCT
gs-4321	165	5	resolved	resolve	VERB
gs-4321	165	6	studies	study	NOUN
gs-4321	165	7	combined	combine	VERB
gs-4321	165	8	with	with	ADP
gs-4321	165	9	vesicle	vesicle	NOUN
gs-4321	165	10	profiling	profiling	NOUN
gs-4321	165	11	suggest	suggest	VERB
gs-4321	165	12	that	that	SCONJ
gs-4321	165	13	microenvironmental	microenvironmental	ADJ
gs-4321	165	14	communication	communication	NOUN
gs-4321	165	15	extends	extend	VERB
gs-4321	165	16	beyond	beyond	ADP
gs-4321	165	17	ligand	ligand	ADJ
gs-4321	165	18	–	–	PUNCT
gs-4321	165	19	receptor	receptor	NOUN
gs-4321	165	20	interactions	interaction	NOUN
gs-4321	165	21	to	to	PART
gs-4321	165	22	include	include	VERB
gs-4321	165	23	the	the	DET
gs-4321	165	24	exchange	exchange	NOUN
gs-4321	165	25	of	of	ADP
gs-4321	165	26	regulatory	regulatory	ADJ
gs-4321	165	27	cargoes	cargoes	ADJ
gs-4321	165	28	capable	capable	ADJ
gs-4321	165	29	georgian	georgian	NOUN
gs-4321	165	30	scientists/	scientists/	NUM
gs-4321	165	31	.	.	PUNCT
gs-4321	166	1	7	7	NUM
gs-4321	166	2	n	n	DET
gs-4321	166	3	4	4	NUM
gs-4321	166	4	,	,	PUNCT
gs-4321	166	5	2025	2025	NUM
gs-4321	166	6	343	343	NUM
gs-4321	166	7	of	of	ADP
gs-4321	166	8	inducing	induce	VERB
gs-4321	166	9	transcriptional	transcriptional	ADJ
gs-4321	166	10	reprogramming	reprogramming	NOUN
gs-4321	166	11	.	.	PUNCT
gs-4321	167	1	for	for	ADP
gs-4321	167	2	example	example	NOUN
gs-4321	167	3	,	,	PUNCT
gs-4321	167	4	vesicle	vesicle	NOUN
gs-4321	167	5	-	-	PUNCT
gs-4321	167	6	mediated	mediate	VERB
gs-4321	167	7	transfer	transfer	NOUN
gs-4321	167	8	of	of	ADP
gs-4321	167	9	micrornas	microrna	NOUN
gs-4321	167	10	or	or	CCONJ
gs-4321	167	11	transcription	transcription	NOUN
gs-4321	167	12	factor	factor	NOUN
gs-4321	167	13	regulators	regulator	NOUN
gs-4321	167	14	can	can	AUX
gs-4321	167	15	modulate	modulate	VERB
gs-4321	167	16	drug	drug	NOUN
gs-4321	167	17	tolerance	tolerance	NOUN
gs-4321	167	18	,	,	PUNCT
gs-4321	167	19	invasiveness	invasiveness	ADJ
gs-4321	167	20	,	,	PUNCT
gs-4321	167	21	and	and	CCONJ
gs-4321	167	22	stress	stress	NOUN
gs-4321	167	23	responses	response	NOUN
gs-4321	167	24	(	(	PUNCT
gs-4321	167	25	becker	becker	PROPN
gs-4321	167	26	et	et	PROPN
gs-4321	167	27	al	al	PROPN
gs-4321	167	28	.	.	PROPN
gs-4321	167	29	,	,	PUNCT
gs-4321	167	30	2016	2016	NUM
gs-4321	167	31	)	)	PUNCT
gs-4321	167	32	.	.	PUNCT
gs-4321	168	1	bioinformatic	bioinformatic	ADJ
gs-4321	168	2	integration	integration	NOUN
gs-4321	168	3	of	of	ADP
gs-4321	168	4	vesicle	vesicle	NOUN
gs-4321	168	5	-	-	PUNCT
gs-4321	168	6	derived	derive	VERB
gs-4321	168	7	signatures	signature	NOUN
gs-4321	168	8	with	with	ADP
gs-4321	168	9	single	single	ADJ
gs-4321	168	10	-	-	PUNCT
gs-4321	168	11	cell	cell	NOUN
gs-4321	168	12	datasets	dataset	NOUN
gs-4321	168	13	offers	offer	VERB
gs-4321	168	14	an	an	DET
gs-4321	168	15	emerging	emerge	VERB
gs-4321	168	16	opportunity	opportunity	NOUN
gs-4321	168	17	to	to	PART
gs-4321	168	18	map	map	VERB
gs-4321	168	19	functional	functional	ADJ
gs-4321	168	20	communication	communication	NOUN
gs-4321	168	21	pathways	pathway	NOUN
gs-4321	168	22	that	that	PRON
gs-4321	168	23	influence	influence	VERB
gs-4321	168	24	phenotypic	phenotypic	ADJ
gs-4321	168	25	transitions	transition	NOUN
gs-4321	168	26	.	.	PUNCT
gs-4321	169	1	spatial	spatial	ADJ
gs-4321	169	2	constraints	constraint	NOUN
gs-4321	169	3	and	and	CCONJ
gs-4321	169	4	niche	niche	NOUN
gs-4321	169	5	-	-	PUNCT
gs-4321	169	6	dependent	dependent	ADJ
gs-4321	169	7	behavior	behavior	NOUN
gs-4321	169	8	spatial	spatial	ADJ
gs-4321	169	9	transcriptomic	transcriptomic	ADJ
gs-4321	169	10	approaches	approach	NOUN
gs-4321	169	11	have	have	AUX
gs-4321	169	12	revealed	reveal	VERB
gs-4321	169	13	that	that	SCONJ
gs-4321	169	14	the	the	DET
gs-4321	169	15	architecture	architecture	NOUN
gs-4321	169	16	of	of	ADP
gs-4321	169	17	the	the	DET
gs-4321	169	18	microenvironment	microenvironment	NOUN
gs-4321	169	19	profoundly	profoundly	ADV
gs-4321	169	20	influences	influence	VERB
gs-4321	169	21	how	how	SCONJ
gs-4321	169	22	malignant	malignant	ADJ
gs-4321	169	23	cells	cell	NOUN
gs-4321	169	24	adopt	adopt	VERB
gs-4321	169	25	or	or	CCONJ
gs-4321	169	26	maintain	maintain	VERB
gs-4321	169	27	stem	stem	NOUN
gs-4321	169	28	-	-	PUNCT
gs-4321	169	29	like	like	ADJ
gs-4321	169	30	programs	program	NOUN
gs-4321	169	31	.	.	PUNCT
gs-4321	170	1	hypoxic	hypoxic	ADJ
gs-4321	170	2	regions	region	NOUN
gs-4321	170	3	,	,	PUNCT
gs-4321	170	4	perivascular	perivascular	ADJ
gs-4321	170	5	niches	niche	NOUN
gs-4321	170	6	,	,	PUNCT
gs-4321	170	7	and	and	CCONJ
gs-4321	170	8	immune	immune	NOUN
gs-4321	170	9	-	-	PUNCT
gs-4321	170	10	suppressed	suppress	VERB
gs-4321	170	11	microdomains	microdomain	NOUN
gs-4321	170	12	often	often	ADV
gs-4321	170	13	harbor	harbor	VERB
gs-4321	170	14	distinct	distinct	ADJ
gs-4321	170	15	transcriptional	transcriptional	ADJ
gs-4321	170	16	profiles	profile	NOUN
gs-4321	170	17	indicative	indicative	ADJ
gs-4321	170	18	of	of	ADP
gs-4321	170	19	enhanced	enhanced	ADJ
gs-4321	170	20	plasticity	plasticity	NOUN
gs-4321	170	21	or	or	CCONJ
gs-4321	170	22	therapyresistant	therapyresistant	ADJ
gs-4321	170	23	states	state	NOUN
gs-4321	170	24	(	(	PUNCT
gs-4321	170	25	jensen	jensen	PROPN
gs-4321	170	26	et	et	PROPN
gs-4321	170	27	al	al	PROPN
gs-4321	170	28	.	.	PROPN
gs-4321	170	29	,	,	PUNCT
gs-4321	170	30	2021	2021	NUM
gs-4321	170	31	)	)	PUNCT
gs-4321	170	32	.	.	PUNCT
gs-4321	171	1	computational	computational	ADJ
gs-4321	171	2	frameworks	framework	NOUN
gs-4321	171	3	for	for	ADP
gs-4321	171	4	spatially	spatially	ADV
gs-4321	171	5	aware	aware	ADJ
gs-4321	171	6	clustering	clustering	NOUN
gs-4321	171	7	and	and	CCONJ
gs-4321	171	8	niche	niche	NOUN
gs-4321	171	9	identification	identification	NOUN
gs-4321	171	10	permit	permit	VERB
gs-4321	171	11	systematic	systematic	ADJ
gs-4321	171	12	analysis	analysis	NOUN
gs-4321	171	13	of	of	ADP
gs-4321	171	14	how	how	SCONJ
gs-4321	171	15	local	local	ADJ
gs-4321	171	16	microenvironmental	microenvironmental	ADJ
gs-4321	171	17	features	feature	NOUN
gs-4321	171	18	shape	shape	VERB
gs-4321	171	19	functional	functional	ADJ
gs-4321	171	20	cell	cell	NOUN
gs-4321	171	21	states	state	NOUN
gs-4321	171	22	.	.	PUNCT
gs-4321	172	1	these	these	DET
gs-4321	172	2	approaches	approach	NOUN
gs-4321	172	3	are	be	AUX
gs-4321	172	4	critical	critical	ADJ
gs-4321	172	5	for	for	ADP
gs-4321	172	6	identifying	identify	VERB
gs-4321	172	7	spatially	spatially	ADV
gs-4321	172	8	restricted	restrict	VERB
gs-4321	172	9	regulators	regulator	NOUN
gs-4321	172	10	of	of	ADP
gs-4321	172	11	state	state	NOUN
gs-4321	172	12	transitions	transition	NOUN
gs-4321	172	13	and	and	CCONJ
gs-4321	172	14	for	for	ADP
gs-4321	172	15	elucidating	elucidating	NOUN
gs-4321	172	16	mechanisms	mechanism	NOUN
gs-4321	172	17	through	through	ADP
gs-4321	172	18	which	which	PRON
gs-4321	172	19	tumors	tumor	NOUN
gs-4321	172	20	maintain	maintain	VERB
gs-4321	172	21	heterogeneous	heterogeneous	ADJ
gs-4321	172	22	populations	population	NOUN
gs-4321	172	23	capable	capable	ADJ
gs-4321	172	24	of	of	ADP
gs-4321	172	25	rapid	rapid	ADJ
gs-4321	172	26	adaptation	adaptation	NOUN
gs-4321	172	27	.	.	PUNCT
gs-4321	173	1	the	the	DET
gs-4321	173	2	need	need	NOUN
gs-4321	173	3	for	for	ADP
gs-4321	173	4	unified	unified	ADJ
gs-4321	173	5	analytical	analytical	ADJ
gs-4321	173	6	strategies	strategy	NOUN
gs-4321	173	7	given	give	VERB
gs-4321	173	8	the	the	DET
gs-4321	173	9	multilayered	multilayered	ADJ
gs-4321	173	10	and	and	CCONJ
gs-4321	173	11	interconnected	interconnected	ADJ
gs-4321	173	12	nature	nature	NOUN
gs-4321	173	13	of	of	ADP
gs-4321	173	14	these	these	DET
gs-4321	173	15	regulatory	regulatory	ADJ
gs-4321	173	16	influences	influence	NOUN
gs-4321	173	17	,	,	PUNCT
gs-4321	173	18	unified	unified	ADJ
gs-4321	173	19	bioinformatic	bioinformatic	ADJ
gs-4321	173	20	strategies	strategy	NOUN
gs-4321	173	21	integrating	integrate	VERB
gs-4321	173	22	transcriptomic	transcriptomic	ADJ
gs-4321	173	23	,	,	PUNCT
gs-4321	173	24	epigenomic	epigenomic	ADJ
gs-4321	173	25	,	,	PUNCT
gs-4321	173	26	proteogenomic	proteogenomic	ADJ
gs-4321	173	27	,	,	PUNCT
gs-4321	173	28	and	and	CCONJ
gs-4321	173	29	spatial	spatial	ADJ
gs-4321	173	30	information	information	NOUN
gs-4321	173	31	are	be	AUX
gs-4321	173	32	necessary	necessary	ADJ
gs-4321	173	33	to	to	PART
gs-4321	173	34	fully	fully	ADV
gs-4321	173	35	decode	decode	VERB
gs-4321	173	36	the	the	DET
gs-4321	173	37	mechanisms	mechanism	NOUN
gs-4321	173	38	governing	govern	VERB
gs-4321	173	39	phenotypic	phenotypic	ADJ
gs-4321	173	40	flexibility	flexibility	NOUN
gs-4321	173	41	.	.	PUNCT
gs-4321	174	1	single	single	ADJ
gs-4321	174	2	-	-	PUNCT
gs-4321	174	3	cell	cell	NOUN
gs-4321	174	4	computational	computational	ADJ
gs-4321	174	5	tools	tool	NOUN
gs-4321	174	6	have	have	AUX
gs-4321	174	7	matured	mature	VERB
gs-4321	174	8	to	to	ADP
gs-4321	174	9	a	a	DET
gs-4321	174	10	point	point	NOUN
gs-4321	174	11	where	where	SCONJ
gs-4321	174	12	these	these	DET
gs-4321	174	13	integrations	integration	NOUN
gs-4321	174	14	are	be	AUX
gs-4321	174	15	feasible	feasible	ADJ
gs-4321	174	16	,	,	PUNCT
gs-4321	174	17	setting	set	VERB
gs-4321	174	18	the	the	DET
gs-4321	174	19	stage	stage	NOUN
gs-4321	174	20	for	for	ADP
gs-4321	174	21	high	high	ADJ
gs-4321	174	22	-	-	PUNCT
gs-4321	174	23	resolution	resolution	NOUN
gs-4321	174	24	characterization	characterization	NOUN
gs-4321	174	25	of	of	ADP
gs-4321	174	26	plasticity	plasticity	NOUN
gs-4321	174	27	across	across	ADP
gs-4321	174	28	malignancies	malignancy	NOUN
gs-4321	174	29	.	.	PUNCT
gs-4321	175	1	molecular	molecular	ADJ
gs-4321	175	2	drivers	driver	NOUN
gs-4321	175	3	of	of	ADP
gs-4321	175	4	phenotypic	phenotypic	ADJ
gs-4321	175	5	plasticity	plasticity	NOUN
gs-4321	175	6	at	at	ADP
gs-4321	175	7	the	the	DET
gs-4321	175	8	core	core	NOUN
gs-4321	175	9	of	of	ADP
gs-4321	175	10	state	state	NOUN
gs-4321	175	11	transitions	transition	NOUN
gs-4321	175	12	within	within	ADP
gs-4321	175	13	malignant	malignant	ADJ
gs-4321	175	14	populations	population	NOUN
gs-4321	175	15	are	be	AUX
gs-4321	175	16	complex	complex	ADJ
gs-4321	175	17	regulatory	regulatory	ADJ
gs-4321	175	18	mechanisms	mechanism	NOUN
gs-4321	175	19	controlled	control	VERB
gs-4321	175	20	by	by	ADP
gs-4321	175	21	transcription	transcription	NOUN
gs-4321	175	22	factors	factor	NOUN
gs-4321	175	23	,	,	PUNCT
gs-4321	175	24	chromatin	chromatin	NOUN
gs-4321	175	25	-	-	PUNCT
gs-4321	175	26	modifying	modify	VERB
gs-4321	175	27	enzymes	enzyme	NOUN
gs-4321	175	28	,	,	PUNCT
gs-4321	175	29	and	and	CCONJ
gs-4321	175	30	signaling	signal	VERB
gs-4321	175	31	cascades	cascade	NOUN
gs-4321	175	32	that	that	PRON
gs-4321	175	33	dynamically	dynamically	ADV
gs-4321	175	34	shape	shape	VERB
gs-4321	175	35	cellular	cellular	ADJ
gs-4321	175	36	identity	identity	NOUN
gs-4321	175	37	.	.	PUNCT
gs-4321	176	1	numerous	numerous	ADJ
gs-4321	176	2	studies	study	NOUN
gs-4321	176	3	have	have	AUX
gs-4321	176	4	identified	identify	VERB
gs-4321	176	5	transcriptional	transcriptional	ADJ
gs-4321	176	6	regulators	regulator	NOUN
gs-4321	176	7	associated	associate	VERB
gs-4321	176	8	with	with	ADP
gs-4321	176	9	stem	stem	NOUN
gs-4321	176	10	-	-	PUNCT
gs-4321	176	11	like	like	ADJ
gs-4321	176	12	programs	program	NOUN
gs-4321	176	13	,	,	PUNCT
gs-4321	176	14	including	include	VERB
gs-4321	176	15	sox2	sox2	NOUN
gs-4321	176	16	,	,	PUNCT
gs-4321	176	17	nanog	nanog	PROPN
gs-4321	176	18	,	,	PUNCT
gs-4321	176	19	oct4	oct4	PROPN
gs-4321	176	20	,	,	PUNCT
gs-4321	176	21	zeb1	zeb1	PROPN
gs-4321	176	22	,	,	PUNCT
gs-4321	176	23	klf4	klf4	PROPN
gs-4321	176	24	,	,	PUNCT
gs-4321	176	25	and	and	CCONJ
gs-4321	176	26	myc	myc	PROPN
gs-4321	176	27	,	,	PUNCT
gs-4321	176	28	which	which	PRON
gs-4321	176	29	integrate	integrate	VERB
gs-4321	176	30	external	external	ADJ
gs-4321	176	31	cues	cue	NOUN
gs-4321	176	32	into	into	ADP
gs-4321	176	33	intracellular	intracellular	ADJ
gs-4321	176	34	reprogramming	reprogramme	VERB
gs-4321	176	35	events	event	NOUN
gs-4321	176	36	(	(	PUNCT
gs-4321	176	37	lu	lu	NOUN
gs-4321	176	38	et	et	PROPN
gs-4321	176	39	al	al	PROPN
gs-4321	176	40	.	.	PROPN
gs-4321	176	41	,	,	PUNCT
gs-4321	176	42	2014	2014	NUM
gs-4321	176	43	;	;	PUNCT
gs-4321	176	44	chaffer	chaffer	VERB
gs-4321	176	45	et	et	NOUN
gs-4321	176	46	al	al	PROPN
gs-4321	176	47	.	.	PROPN
gs-4321	176	48	,	,	PUNCT
gs-4321	176	49	2013	2013	NUM
gs-4321	176	50	)	)	PUNCT
gs-4321	176	51	.	.	PUNCT
gs-4321	177	1	these	these	DET
gs-4321	177	2	regulators	regulator	NOUN
gs-4321	177	3	do	do	AUX
gs-4321	177	4	not	not	PART
gs-4321	177	5	act	act	VERB
gs-4321	177	6	in	in	ADP
gs-4321	177	7	isolation	isolation	NOUN
gs-4321	177	8	;	;	PUNCT
gs-4321	177	9	instead	instead	ADV
gs-4321	177	10	,	,	PUNCT
gs-4321	177	11	they	they	PRON
gs-4321	177	12	participate	participate	VERB
gs-4321	177	13	in	in	ADP
gs-4321	177	14	interconnected	interconnected	ADJ
gs-4321	177	15	feedback	feedback	NOUN
gs-4321	177	16	loops	loop	NOUN
gs-4321	177	17	that	that	PRON
gs-4321	177	18	stabilize	stabilize	VERB
gs-4321	177	19	particular	particular	ADJ
gs-4321	177	20	phenotypes	phenotype	NOUN
gs-4321	177	21	or	or	CCONJ
gs-4321	177	22	promote	promote	VERB
gs-4321	177	23	oscillations	oscillation	NOUN
gs-4321	177	24	between	between	ADP
gs-4321	177	25	states	state	NOUN
gs-4321	177	26	depending	depend	VERB
gs-4321	177	27	on	on	ADP
gs-4321	177	28	microenvironmental	microenvironmental	ADJ
gs-4321	177	29	context	context	NOUN
gs-4321	177	30	and	and	CCONJ
gs-4321	177	31	stress	stress	NOUN
gs-4321	177	32	exposure	exposure	NOUN
gs-4321	177	33	.	.	PUNCT
gs-4321	178	1	the	the	DET
gs-4321	178	2	capacity	capacity	NOUN
gs-4321	178	3	of	of	ADP
gs-4321	178	4	malignant	malignant	ADJ
gs-4321	178	5	cells	cell	NOUN
gs-4321	178	6	to	to	PART
gs-4321	178	7	activate	activate	VERB
gs-4321	178	8	or	or	CCONJ
gs-4321	178	9	suppress	suppress	VERB
gs-4321	178	10	these	these	DET
gs-4321	178	11	networks	network	NOUN
gs-4321	178	12	underlies	underlie	VERB
gs-4321	178	13	their	their	PRON
gs-4321	178	14	remarkable	remarkable	ADJ
gs-4321	178	15	adaptability	adaptability	NOUN
gs-4321	178	16	,	,	PUNCT
gs-4321	178	17	enabling	enable	VERB
gs-4321	178	18	escape	escape	NOUN
gs-4321	178	19	from	from	ADP
gs-4321	178	20	targeted	target	VERB
gs-4321	178	21	therapies	therapy	NOUN
gs-4321	178	22	and	and	CCONJ
gs-4321	178	23	conventional	conventional	ADJ
gs-4321	178	24	cytotoxic	cytotoxic	ADJ
gs-4321	178	25	agents	agent	NOUN
gs-4321	178	26	.	.	PUNCT
gs-4321	179	1	epigenetic	epigenetic	ADJ
gs-4321	179	2	plasticity	plasticity	NOUN
gs-4321	179	3	and	and	CCONJ
gs-4321	179	4	chromatin	chromatin	NOUN
gs-4321	179	5	dynamics	dynamic	NOUN
gs-4321	179	6	epigenetic	epigenetic	ADJ
gs-4321	179	7	modulation	modulation	NOUN
gs-4321	179	8	plays	play	VERB
gs-4321	179	9	a	a	DET
gs-4321	179	10	fundamental	fundamental	ADJ
gs-4321	179	11	role	role	NOUN
gs-4321	179	12	in	in	ADP
gs-4321	179	13	establishing	establish	VERB
gs-4321	179	14	permissive	permissive	ADJ
gs-4321	179	15	or	or	CCONJ
gs-4321	179	16	restrictive	restrictive	ADJ
gs-4321	179	17	landscapes	landscape	NOUN
gs-4321	179	18	for	for	ADP
gs-4321	179	19	transcriptional	transcriptional	ADJ
gs-4321	179	20	transitions	transition	NOUN
gs-4321	179	21	.	.	PUNCT
gs-4321	180	1	chromatin	chromatin	NOUN
gs-4321	180	2	remodeling	remodeling	NOUN
gs-4321	180	3	complexes	complex	NOUN
gs-4321	180	4	,	,	PUNCT
gs-4321	180	5	histone	histone	NOUN
gs-4321	180	6	modification	modification	NOUN
gs-4321	180	7	enzymes	enzyme	NOUN
gs-4321	180	8	,	,	PUNCT
gs-4321	180	9	and	and	CCONJ
gs-4321	180	10	dna	dna	PROPN
gs-4321	180	11	methylation	methylation	NOUN
gs-4321	180	12	machinery	machinery	NOUN
gs-4321	180	13	contribute	contribute	VERB
gs-4321	180	14	to	to	ADP
gs-4321	180	15	the	the	DET
gs-4321	180	16	regulation	regulation	NOUN
gs-4321	180	17	of	of	ADP
gs-4321	180	18	georgian	georgian	NOUN
gs-4321	180	19	scientists/	scientists/	NUM
gs-4321	180	20	.	.	PUNCT
gs-4321	181	1	7	7	NUM
gs-4321	181	2	n	n	DET
gs-4321	181	3	4	4	NUM
gs-4321	181	4	,	,	PUNCT
gs-4321	181	5	2025	2025	NUM
gs-4321	181	6	344	344	NUM
gs-4321	181	7	accessibility	accessibility	NOUN
gs-4321	181	8	patterns	pattern	NOUN
gs-4321	181	9	that	that	PRON
gs-4321	181	10	define	define	VERB
gs-4321	181	11	lineage	lineage	NOUN
gs-4321	181	12	potentials	potential	NOUN
gs-4321	181	13	.	.	PUNCT
gs-4321	182	1	single	single	ADJ
gs-4321	182	2	-	-	PUNCT
gs-4321	182	3	cell	cell	NOUN
gs-4321	182	4	atac	atac	NOUN
gs-4321	182	5	-	-	PUNCT
gs-4321	182	6	seq	seq	NOUN
gs-4321	182	7	and	and	CCONJ
gs-4321	182	8	multimodal	multimodal	NOUN
gs-4321	182	9	profiling	profiling	NOUN
gs-4321	182	10	have	have	AUX
gs-4321	182	11	shown	show	VERB
gs-4321	182	12	that	that	SCONJ
gs-4321	182	13	chromatin	chromatin	NOUN
gs-4321	182	14	accessibility	accessibility	NOUN
gs-4321	182	15	landscapes	landscape	NOUN
gs-4321	182	16	associated	associate	VERB
gs-4321	182	17	with	with	ADP
gs-4321	182	18	stem	stem	NOUN
gs-4321	182	19	-	-	PUNCT
gs-4321	182	20	like	like	ADJ
gs-4321	182	21	phenotypes	phenotype	NOUN
gs-4321	182	22	are	be	AUX
gs-4321	182	23	more	more	ADV
gs-4321	182	24	open	open	ADJ
gs-4321	182	25	,	,	PUNCT
gs-4321	182	26	flexible	flexible	ADJ
gs-4321	182	27	,	,	PUNCT
gs-4321	182	28	and	and	CCONJ
gs-4321	182	29	enriched	enrich	VERB
gs-4321	182	30	for	for	ADP
gs-4321	182	31	motifs	motif	NOUN
gs-4321	182	32	associated	associate	VERB
gs-4321	182	33	with	with	ADP
gs-4321	182	34	stressresponsive	stressresponsive	ADJ
gs-4321	182	35	transcription	transcription	NOUN
gs-4321	182	36	factors	factor	NOUN
gs-4321	182	37	such	such	ADJ
gs-4321	182	38	as	as	ADP
gs-4321	182	39	ap-1	ap-1	NOUN
gs-4321	182	40	,	,	PUNCT
gs-4321	182	41	stat3	stat3	NOUN
gs-4321	182	42	,	,	PUNCT
gs-4321	182	43	and	and	CCONJ
gs-4321	182	44	nfb	nfb	NOUN
gs-4321	182	45	(	(	PUNCT
gs-4321	182	46	buenrostro	buenrostro	X
gs-4321	182	47	et	et	PROPN
gs-4321	182	48	al	al	PROPN
gs-4321	182	49	.	.	PROPN
gs-4321	182	50	,	,	PUNCT
gs-4321	182	51	2015	2015	NUM
gs-4321	182	52	;	;	PUNCT
gs-4321	182	53	corces	corce	NOUN
gs-4321	182	54	et	et	PROPN
gs-4321	182	55	al	al	PROPN
gs-4321	182	56	.	.	PROPN
gs-4321	182	57	,	,	PUNCT
gs-4321	182	58	2018	2018	NUM
gs-4321	182	59	)	)	PUNCT
gs-4321	182	60	.	.	PUNCT
gs-4321	183	1	these	these	DET
gs-4321	183	2	findings	finding	NOUN
gs-4321	183	3	emphasize	emphasize	VERB
gs-4321	183	4	that	that	SCONJ
gs-4321	183	5	plasticity	plasticity	NOUN
gs-4321	183	6	is	be	AUX
gs-4321	183	7	not	not	PART
gs-4321	183	8	merely	merely	ADV
gs-4321	183	9	a	a	DET
gs-4321	183	10	transcriptional	transcriptional	ADJ
gs-4321	183	11	phenomenon	phenomenon	NOUN
gs-4321	183	12	but	but	CCONJ
gs-4321	183	13	also	also	ADV
gs-4321	183	14	derives	derive	VERB
gs-4321	183	15	from	from	ADP
gs-4321	183	16	deeper	deep	ADJ
gs-4321	183	17	regulatory	regulatory	ADJ
gs-4321	183	18	structures	structure	NOUN
gs-4321	183	19	governing	govern	VERB
gs-4321	183	20	genome	genome	NOUN
gs-4321	183	21	architecture	architecture	NOUN
gs-4321	183	22	.	.	PUNCT
gs-4321	184	1	dynamic	dynamic	ADJ
gs-4321	184	2	modulation	modulation	NOUN
gs-4321	184	3	of	of	ADP
gs-4321	184	4	enhancer	enhancer	NOUN
gs-4321	184	5	landscapes	landscape	NOUN
gs-4321	184	6	has	have	AUX
gs-4321	184	7	been	be	AUX
gs-4321	184	8	particularly	particularly	ADV
gs-4321	184	9	implicated	implicate	VERB
gs-4321	184	10	in	in	ADP
gs-4321	184	11	adaptive	adaptive	ADJ
gs-4321	184	12	transitions	transition	NOUN
gs-4321	184	13	.	.	PUNCT
gs-4321	185	1	studies	study	NOUN
gs-4321	185	2	in	in	ADP
gs-4321	185	3	breast	breast	NOUN
gs-4321	185	4	cancer	cancer	NOUN
gs-4321	185	5	have	have	AUX
gs-4321	185	6	shown	show	VERB
gs-4321	185	7	that	that	SCONJ
gs-4321	185	8	chromatin	chromatin	NOUN
gs-4321	185	9	reorganization	reorganization	NOUN
gs-4321	185	10	under	under	ADP
gs-4321	185	11	therapy	therapy	NOUN
gs-4321	185	12	pressure	pressure	NOUN
gs-4321	185	13	leads	lead	VERB
gs-4321	185	14	to	to	ADP
gs-4321	185	15	activation	activation	NOUN
gs-4321	185	16	of	of	ADP
gs-4321	185	17	alternative	alternative	ADJ
gs-4321	185	18	enhancer	enhancer	NOUN
gs-4321	185	19	modules	module	NOUN
gs-4321	185	20	that	that	PRON
gs-4321	185	21	promote	promote	VERB
gs-4321	185	22	resistance	resistance	NOUN
gs-4321	185	23	-	-	PUNCT
gs-4321	185	24	associated	associate	VERB
gs-4321	185	25	states	state	NOUN
gs-4321	185	26	(	(	PUNCT
gs-4321	185	27	pérez	pérez	NOUN
gs-4321	185	28	-	-	PUNCT
gs-4321	185	29	garcía	garcía	VERB
gs-4321	185	30	et	et	PROPN
gs-4321	185	31	al	al	PROPN
gs-4321	185	32	.	.	PROPN
gs-4321	185	33	,	,	PUNCT
gs-4321	185	34	2022	2022	NUM
gs-4321	185	35	)	)	PUNCT
gs-4321	185	36	.	.	PUNCT
gs-4321	186	1	similarly	similarly	ADV
gs-4321	186	2	,	,	PUNCT
gs-4321	186	3	melanoma	melanoma	NOUN
gs-4321	186	4	cells	cell	NOUN
gs-4321	186	5	undergoing	undergo	VERB
gs-4321	186	6	dedifferentiation	dedifferentiation	NOUN
gs-4321	186	7	exhibit	exhibit	VERB
gs-4321	186	8	pronounced	pronounce	VERB
gs-4321	186	9	shifts	shift	NOUN
gs-4321	186	10	in	in	ADP
gs-4321	186	11	h3k27ac	h3k27ac	NOUN
gs-4321	186	12	-	-	PUNCT
gs-4321	186	13	marked	mark	VERB
gs-4321	186	14	enhancer	enhancer	NOUN
gs-4321	186	15	regions	region	NOUN
gs-4321	186	16	corresponding	correspond	VERB
gs-4321	186	17	to	to	ADP
gs-4321	186	18	key	key	ADJ
gs-4321	186	19	regulators	regulator	NOUN
gs-4321	186	20	of	of	ADP
gs-4321	186	21	invasiveness	invasiveness	ADJ
gs-4321	186	22	and	and	CCONJ
gs-4321	186	23	drug	drug	NOUN
gs-4321	186	24	tolerance	tolerance	NOUN
gs-4321	186	25	(	(	PUNCT
gs-4321	186	26	tsoi	tsoi	PROPN
gs-4321	186	27	et	et	PROPN
gs-4321	186	28	al	al	PROPN
gs-4321	186	29	.	.	PROPN
gs-4321	186	30	,	,	PUNCT
gs-4321	186	31	2018	2018	NUM
gs-4321	186	32	)	)	PUNCT
gs-4321	186	33	.	.	PUNCT
gs-4321	187	1	these	these	DET
gs-4321	187	2	insights	insight	NOUN
gs-4321	187	3	highlight	highlight	VERB
gs-4321	187	4	the	the	DET
gs-4321	187	5	importance	importance	NOUN
gs-4321	187	6	of	of	ADP
gs-4321	187	7	integrating	integrate	VERB
gs-4321	187	8	epigenomic	epigenomic	ADJ
gs-4321	187	9	signals	signal	NOUN
gs-4321	187	10	into	into	ADP
gs-4321	187	11	bioinformatic	bioinformatic	ADJ
gs-4321	187	12	pipelines	pipeline	NOUN
gs-4321	187	13	aimed	aim	VERB
gs-4321	187	14	at	at	ADP
gs-4321	187	15	deciphering	decipher	VERB
gs-4321	187	16	the	the	DET
gs-4321	187	17	regulatory	regulatory	ADJ
gs-4321	187	18	logic	logic	NOUN
gs-4321	187	19	of	of	ADP
gs-4321	187	20	cellular	cellular	ADJ
gs-4321	187	21	adaptability	adaptability	NOUN
gs-4321	187	22	.	.	PUNCT
gs-4321	188	1	metabolic	metabolic	NOUN
gs-4321	188	2	reprogramming	reprogramme	VERB
gs-4321	188	3	as	as	ADP
gs-4321	188	4	a	a	DET
gs-4321	188	5	plasticity	plasticity	NOUN
gs-4321	188	6	mechanism	mechanism	NOUN
gs-4321	188	7	another	another	DET
gs-4321	188	8	layer	layer	NOUN
gs-4321	188	9	of	of	ADP
gs-4321	188	10	regulation	regulation	NOUN
gs-4321	188	11	involves	involve	VERB
gs-4321	188	12	metabolic	metabolic	ADJ
gs-4321	188	13	remodeling	remodeling	NOUN
gs-4321	188	14	,	,	PUNCT
gs-4321	188	15	as	as	SCONJ
gs-4321	188	16	cellular	cellular	ADJ
gs-4321	188	17	states	state	NOUN
gs-4321	188	18	are	be	AUX
gs-4321	188	19	tightly	tightly	ADV
gs-4321	188	20	coupled	couple	VERB
gs-4321	188	21	to	to	ADP
gs-4321	188	22	energy	energy	NOUN
gs-4321	188	23	availability	availability	NOUN
gs-4321	188	24	,	,	PUNCT
gs-4321	188	25	redox	redox	NOUN
gs-4321	188	26	homeostasis	homeostasis	NOUN
gs-4321	188	27	,	,	PUNCT
gs-4321	188	28	and	and	CCONJ
gs-4321	188	29	biosynthetic	biosynthetic	ADJ
gs-4321	188	30	demands	demand	NOUN
gs-4321	188	31	.	.	PUNCT
gs-4321	189	1	stemassociated	stemassociate	VERB
gs-4321	189	2	phenotypes	phenotype	NOUN
gs-4321	189	3	often	often	ADV
gs-4321	189	4	rely	rely	VERB
gs-4321	189	5	on	on	ADP
gs-4321	189	6	flexible	flexible	ADJ
gs-4321	189	7	metabolic	metabolic	NOUN
gs-4321	189	8	programs	program	NOUN
gs-4321	189	9	,	,	PUNCT
gs-4321	189	10	including	include	VERB
gs-4321	189	11	enhanced	enhanced	ADJ
gs-4321	189	12	glycolysis	glycolysis	NOUN
gs-4321	189	13	,	,	PUNCT
gs-4321	189	14	altered	alter	VERB
gs-4321	189	15	amino	amino	NOUN
gs-4321	189	16	acid	acid	NOUN
gs-4321	189	17	utilization	utilization	NOUN
gs-4321	189	18	,	,	PUNCT
gs-4321	189	19	and	and	CCONJ
gs-4321	189	20	shifts	shift	NOUN
gs-4321	189	21	in	in	ADP
gs-4321	189	22	mitochondrial	mitochondrial	ADJ
gs-4321	189	23	dynamics	dynamic	NOUN
gs-4321	189	24	(	(	PUNCT
gs-4321	189	25	faubert	faubert	NOUN
gs-4321	189	26	et	et	PROPN
gs-4321	189	27	al	al	PROPN
gs-4321	189	28	.	.	PROPN
gs-4321	189	29	,	,	PUNCT
gs-4321	189	30	2020	2020	NUM
gs-4321	189	31	)	)	PUNCT
gs-4321	189	32	.	.	PUNCT
gs-4321	190	1	single	single	ADJ
gs-4321	190	2	-	-	PUNCT
gs-4321	190	3	cell	cell	NOUN
gs-4321	190	4	metabolic	metabolic	NOUN
gs-4321	190	5	inference	inference	NOUN
gs-4321	190	6	tools	tool	NOUN
gs-4321	190	7	—	—	PUNCT
gs-4321	190	8	such	such	ADJ
gs-4321	190	9	as	as	ADP
gs-4321	190	10	scmetabolism	scmetabolism	NOUN
gs-4321	190	11	and	and	CCONJ
gs-4321	190	12	compass	compass	ADJ
gs-4321	190	13	—	—	PUNCT
gs-4321	190	14	allow	allow	VERB
gs-4321	190	15	bioinformatic	bioinformatic	ADJ
gs-4321	190	16	estimation	estimation	NOUN
gs-4321	190	17	of	of	ADP
gs-4321	190	18	pathway	pathway	NOUN
gs-4321	190	19	activity	activity	NOUN
gs-4321	190	20	from	from	ADP
gs-4321	190	21	transcriptomic	transcriptomic	ADJ
gs-4321	190	22	data	datum	NOUN
gs-4321	190	23	,	,	PUNCT
gs-4321	190	24	revealing	reveal	VERB
gs-4321	190	25	how	how	SCONJ
gs-4321	190	26	metabolic	metabolic	ADJ
gs-4321	190	27	fluxes	flux	NOUN
gs-4321	190	28	correlate	correlate	VERB
gs-4321	190	29	with	with	ADP
gs-4321	190	30	phenotypic	phenotypic	ADJ
gs-4321	190	31	transitions	transition	NOUN
gs-4321	190	32	.	.	PUNCT
gs-4321	191	1	for	for	ADP
gs-4321	191	2	example	example	NOUN
gs-4321	191	3	,	,	PUNCT
gs-4321	191	4	drug	drug	NOUN
gs-4321	191	5	-	-	PUNCT
gs-4321	191	6	tolerant	tolerant	ADJ
gs-4321	191	7	persister	persister	NOUN
gs-4321	191	8	cells	cell	NOUN
gs-4321	191	9	frequently	frequently	ADV
gs-4321	191	10	display	display	VERB
gs-4321	191	11	upregulation	upregulation	NOUN
gs-4321	191	12	of	of	ADP
gs-4321	191	13	oxidative	oxidative	ADJ
gs-4321	191	14	stress	stress	NOUN
gs-4321	191	15	defense	defense	NOUN
gs-4321	191	16	pathways	pathway	NOUN
gs-4321	191	17	and	and	CCONJ
gs-4321	191	18	lipid	lipid	NOUN
gs-4321	191	19	metabolism	metabolism	NOUN
gs-4321	191	20	circuits	circuit	NOUN
gs-4321	191	21	that	that	PRON
gs-4321	191	22	support	support	VERB
gs-4321	191	23	survival	survival	NOUN
gs-4321	191	24	under	under	ADP
gs-4321	191	25	extreme	extreme	ADJ
gs-4321	191	26	conditions	condition	NOUN
gs-4321	191	27	(	(	PUNCT
gs-4321	191	28	hangauer	hangauer	VERB
gs-4321	191	29	et	et	PROPN
gs-4321	191	30	al	al	PROPN
gs-4321	191	31	.	.	PROPN
gs-4321	191	32	,	,	PUNCT
gs-4321	191	33	2017	2017	NUM
gs-4321	191	34	)	)	PUNCT
gs-4321	191	35	.	.	PUNCT
gs-4321	192	1	incorporating	incorporate	VERB
gs-4321	192	2	these	these	DET
gs-4321	192	3	metabolic	metabolic	NOUN
gs-4321	192	4	signatures	signature	NOUN
gs-4321	192	5	into	into	ADP
gs-4321	192	6	integrative	integrative	ADJ
gs-4321	192	7	single	single	ADJ
gs-4321	192	8	-	-	PUNCT
gs-4321	192	9	cell	cell	NOUN
gs-4321	192	10	analyses	analysis	NOUN
gs-4321	192	11	provides	provide	VERB
gs-4321	192	12	a	a	DET
gs-4321	192	13	more	more	ADV
gs-4321	192	14	complete	complete	ADJ
gs-4321	192	15	understanding	understanding	NOUN
gs-4321	192	16	of	of	ADP
gs-4321	192	17	how	how	SCONJ
gs-4321	192	18	malignant	malignant	ADJ
gs-4321	192	19	cells	cell	NOUN
gs-4321	192	20	achieve	achieve	VERB
gs-4321	192	21	and	and	CCONJ
gs-4321	192	22	maintain	maintain	VERB
gs-4321	192	23	adaptable	adaptable	ADJ
gs-4321	192	24	states	state	NOUN
gs-4321	192	25	.	.	PUNCT
gs-4321	193	1	interplay	interplay	NOUN
gs-4321	193	2	of	of	ADP
gs-4321	193	3	regulatory	regulatory	ADJ
gs-4321	193	4	layers	layer	NOUN
gs-4321	193	5	taken	take	VERB
gs-4321	193	6	together	together	ADV
gs-4321	193	7	,	,	PUNCT
gs-4321	193	8	transcriptional	transcriptional	ADJ
gs-4321	193	9	,	,	PUNCT
gs-4321	193	10	epigenetic	epigenetic	ADJ
gs-4321	193	11	,	,	PUNCT
gs-4321	193	12	and	and	CCONJ
gs-4321	193	13	metabolic	metabolic	NOUN
gs-4321	193	14	components	component	NOUN
gs-4321	193	15	form	form	VERB
gs-4321	193	16	a	a	DET
gs-4321	193	17	multilayered	multilayered	ADJ
gs-4321	193	18	regulatory	regulatory	ADJ
gs-4321	193	19	network	network	NOUN
gs-4321	193	20	in	in	ADP
gs-4321	193	21	which	which	PRON
gs-4321	193	22	each	each	DET
gs-4321	193	23	level	level	NOUN
gs-4321	193	24	influences	influence	VERB
gs-4321	193	25	and	and	CCONJ
gs-4321	193	26	constrains	constrain	VERB
gs-4321	193	27	the	the	DET
gs-4321	193	28	others	other	NOUN
gs-4321	193	29	.	.	PUNCT
gs-4321	194	1	phenotypic	phenotypic	ADJ
gs-4321	194	2	flexibility	flexibility	NOUN
gs-4321	194	3	arises	arise	VERB
gs-4321	194	4	when	when	SCONJ
gs-4321	194	5	malignant	malignant	ADJ
gs-4321	194	6	cells	cell	NOUN
gs-4321	194	7	exploit	exploit	VERB
gs-4321	194	8	this	this	DET
gs-4321	194	9	interconnected	interconnected	ADJ
gs-4321	194	10	architecture	architecture	NOUN
gs-4321	194	11	to	to	PART
gs-4321	194	12	navigate	navigate	VERB
gs-4321	194	13	the	the	DET
gs-4321	194	14	fitness	fitness	NOUN
gs-4321	194	15	landscape	landscape	NOUN
gs-4321	194	16	shaped	shape	VERB
gs-4321	194	17	by	by	ADP
gs-4321	194	18	environmental	environmental	ADJ
gs-4321	194	19	pressures	pressure	NOUN
gs-4321	194	20	.	.	PUNCT
gs-4321	195	1	computational	computational	ADJ
gs-4321	195	2	approaches	approach	NOUN
gs-4321	195	3	capable	capable	ADJ
gs-4321	195	4	of	of	ADP
gs-4321	195	5	integrating	integrate	VERB
gs-4321	195	6	signals	signal	NOUN
gs-4321	195	7	across	across	ADP
gs-4321	195	8	these	these	DET
gs-4321	195	9	layers	layer	NOUN
gs-4321	195	10	are	be	AUX
gs-4321	195	11	essential	essential	ADJ
gs-4321	195	12	for	for	ADP
gs-4321	195	13	identifying	identify	VERB
gs-4321	195	14	the	the	DET
gs-4321	195	15	determinants	determinant	NOUN
gs-4321	195	16	of	of	ADP
gs-4321	195	17	state	state	NOUN
gs-4321	195	18	interconversion	interconversion	NOUN
gs-4321	195	19	and	and	CCONJ
gs-4321	195	20	for	for	ADP
gs-4321	195	21	predicting	predict	VERB
gs-4321	195	22	how	how	SCONJ
gs-4321	195	23	populations	population	NOUN
gs-4321	195	24	will	will	AUX
gs-4321	195	25	respond	respond	VERB
gs-4321	195	26	to	to	ADP
gs-4321	195	27	perturbations	perturbation	NOUN
gs-4321	195	28	.	.	PUNCT
gs-4321	196	1	lineage	lineage	NOUN
gs-4321	196	2	hierarchies	hierarchy	NOUN
gs-4321	196	3	and	and	CCONJ
gs-4321	196	4	cellular	cellular	ADJ
gs-4321	196	5	trajectories	trajectory	NOUN
gs-4321	196	6	understanding	understand	VERB
gs-4321	196	7	how	how	SCONJ
gs-4321	196	8	malignant	malignant	ADJ
gs-4321	196	9	cells	cell	NOUN
gs-4321	196	10	transition	transition	NOUN
gs-4321	196	11	between	between	ADP
gs-4321	196	12	functional	functional	ADJ
gs-4321	196	13	states	state	NOUN
gs-4321	196	14	requires	require	VERB
gs-4321	196	15	careful	careful	ADJ
gs-4321	196	16	examination	examination	NOUN
gs-4321	196	17	of	of	ADP
gs-4321	196	18	lineage	lineage	NOUN
gs-4321	196	19	hierarchies	hierarchy	NOUN
gs-4321	196	20	within	within	ADP
gs-4321	196	21	tumors	tumor	NOUN
gs-4321	196	22	.	.	PUNCT
gs-4321	197	1	early	early	ADJ
gs-4321	197	2	theories	theory	NOUN
gs-4321	197	3	proposed	propose	VERB
gs-4321	197	4	a	a	DET
gs-4321	197	5	unidirectional	unidirectional	ADJ
gs-4321	197	6	georgian	georgian	NOUN
gs-4321	197	7	scientists/	scientists/	NUM
gs-4321	197	8	.	.	PUNCT
gs-4321	198	1	7	7	NUM
gs-4321	198	2	n	n	DET
gs-4321	198	3	4	4	NUM
gs-4321	198	4	,	,	PUNCT
gs-4321	198	5	2025	2025	NUM
gs-4321	198	6	345	345	NUM
gs-4321	198	7	model	model	NOUN
gs-4321	198	8	in	in	ADP
gs-4321	198	9	which	which	PRON
gs-4321	198	10	a	a	DET
gs-4321	198	11	stable	stable	ADJ
gs-4321	198	12	stem	stem	NOUN
gs-4321	198	13	-	-	PUNCT
gs-4321	198	14	like	like	ADJ
gs-4321	198	15	compartment	compartment	NOUN
gs-4321	198	16	gives	give	VERB
gs-4321	198	17	rise	rise	NOUN
gs-4321	198	18	to	to	ADP
gs-4321	198	19	progressively	progressively	ADV
gs-4321	198	20	differentiated	differentiate	VERB
gs-4321	198	21	progeny	progeny	NOUN
gs-4321	198	22	.	.	PUNCT
gs-4321	199	1	however	however	ADV
gs-4321	199	2	,	,	PUNCT
gs-4321	199	3	single	single	ADJ
gs-4321	199	4	-	-	PUNCT
gs-4321	199	5	cell	cell	NOUN
gs-4321	199	6	transcriptomic	transcriptomic	ADJ
gs-4321	199	7	studies	study	NOUN
gs-4321	199	8	across	across	ADP
gs-4321	199	9	cancer	cancer	NOUN
gs-4321	199	10	types	type	NOUN
gs-4321	199	11	now	now	ADV
gs-4321	199	12	demonstrate	demonstrate	VERB
gs-4321	199	13	that	that	SCONJ
gs-4321	199	14	differentiation	differentiation	NOUN
gs-4321	199	15	is	be	AUX
gs-4321	199	16	not	not	PART
gs-4321	199	17	strictly	strictly	ADV
gs-4321	199	18	linear	linear	ADJ
gs-4321	199	19	.	.	PUNCT
gs-4321	200	1	instead	instead	ADV
gs-4321	200	2	,	,	PUNCT
gs-4321	200	3	malignant	malignant	ADJ
gs-4321	200	4	cells	cell	NOUN
gs-4321	200	5	frequently	frequently	ADV
gs-4321	200	6	navigate	navigate	VERB
gs-4321	200	7	branching	branch	VERB
gs-4321	200	8	and	and	CCONJ
gs-4321	200	9	reversible	reversible	ADJ
gs-4321	200	10	trajectories	trajectory	NOUN
gs-4321	200	11	,	,	PUNCT
gs-4321	200	12	characterized	characterize	VERB
gs-4321	200	13	by	by	ADP
gs-4321	200	14	the	the	DET
gs-4321	200	15	presence	presence	NOUN
gs-4321	200	16	of	of	ADP
gs-4321	200	17	intermediate	intermediate	ADJ
gs-4321	200	18	states	state	NOUN
gs-4321	200	19	exhibiting	exhibit	VERB
gs-4321	200	20	partial	partial	ADJ
gs-4321	200	21	stem	stem	NOUN
gs-4321	200	22	-	-	PUNCT
gs-4321	200	23	like	like	ADJ
gs-4321	200	24	or	or	CCONJ
gs-4321	200	25	partially	partially	ADV
gs-4321	200	26	differentiated	differentiate	VERB
gs-4321	200	27	features	feature	NOUN
gs-4321	200	28	(	(	PUNCT
gs-4321	200	29	tirosh	tirosh	NOUN
gs-4321	200	30	et	et	PROPN
gs-4321	200	31	al	al	PROPN
gs-4321	200	32	.	.	PROPN
gs-4321	200	33	,	,	PUNCT
gs-4321	200	34	2016	2016	NUM
gs-4321	200	35	;	;	PUNCT
gs-4321	200	36	neftel	neftel	NOUN
gs-4321	200	37	et	et	PROPN
gs-4321	200	38	al	al	PROPN
gs-4321	200	39	.	.	PROPN
gs-4321	200	40	,	,	PUNCT
gs-4321	200	41	2019	2019	NUM
gs-4321	200	42	)	)	PUNCT
gs-4321	200	43	.	.	PUNCT
gs-4321	201	1	these	these	DET
gs-4321	201	2	intermediate	intermediate	ADJ
gs-4321	201	3	phenotypes	phenotype	NOUN
gs-4321	201	4	often	often	ADV
gs-4321	201	5	represent	represent	VERB
gs-4321	201	6	highly	highly	ADV
gs-4321	201	7	plastic	plastic	ADJ
gs-4321	201	8	configurations	configuration	NOUN
gs-4321	201	9	capable	capable	ADJ
gs-4321	201	10	of	of	ADP
gs-4321	201	11	adapting	adapt	VERB
gs-4321	201	12	to	to	ADP
gs-4321	201	13	environmental	environmental	ADJ
gs-4321	201	14	constraints	constraint	NOUN
gs-4321	201	15	and	and	CCONJ
gs-4321	201	16	re	re	ADJ
gs-4321	201	17	-	-	ADJ
gs-4321	201	18	entering	enter	VERB
gs-4321	201	19	stem	stem	NOUN
gs-4321	201	20	-	-	PUNCT
gs-4321	201	21	like	like	ADJ
gs-4321	201	22	programs	program	NOUN
gs-4321	201	23	when	when	SCONJ
gs-4321	201	24	advantageous	advantageous	ADJ
gs-4321	201	25	.	.	PUNCT
gs-4321	202	1	trajectory	trajectory	NOUN
gs-4321	202	2	inference	inference	NOUN
gs-4321	202	3	algorithms	algorithm	NOUN
gs-4321	202	4	,	,	PUNCT
gs-4321	202	5	including	include	VERB
gs-4321	202	6	monocle	monocle	NOUN
gs-4321	202	7	,	,	PUNCT
gs-4321	202	8	slingshot	slingshot	NOUN
gs-4321	202	9	,	,	PUNCT
gs-4321	202	10	and	and	CCONJ
gs-4321	202	11	paga	paga	NOUN
gs-4321	202	12	,	,	PUNCT
gs-4321	202	13	have	have	AUX
gs-4321	202	14	been	be	AUX
gs-4321	202	15	instrumental	instrumental	ADJ
gs-4321	202	16	in	in	ADP
gs-4321	202	17	mapping	map	VERB
gs-4321	202	18	these	these	DET
gs-4321	202	19	transitions	transition	NOUN
gs-4321	202	20	,	,	PUNCT
gs-4321	202	21	providing	provide	VERB
gs-4321	202	22	a	a	DET
gs-4321	202	23	computational	computational	ADJ
gs-4321	202	24	basis	basis	NOUN
gs-4321	202	25	for	for	ADP
gs-4321	202	26	reconstructing	reconstruct	VERB
gs-4321	202	27	state	state	NOUN
gs-4321	202	28	progression	progression	NOUN
gs-4321	202	29	using	use	VERB
gs-4321	202	30	transcriptomic	transcriptomic	ADJ
gs-4321	202	31	similarity	similarity	NOUN
gs-4321	202	32	as	as	ADP
gs-4321	202	33	a	a	DET
gs-4321	202	34	proxy	proxy	NOUN
gs-4321	202	35	for	for	ADP
gs-4321	202	36	developmental	developmental	ADJ
gs-4321	202	37	time	time	NOUN
gs-4321	202	38	(	(	PUNCT
gs-4321	202	39	trapnell	trapnell	NOUN
gs-4321	202	40	et	et	NOUN
gs-4321	202	41	al	al	PROPN
gs-4321	202	42	.	.	PROPN
gs-4321	202	43	,	,	PUNCT
gs-4321	202	44	2014	2014	NUM
gs-4321	202	45	;	;	PUNCT
gs-4321	202	46	street	street	NOUN
gs-4321	202	47	et	et	PROPN
gs-4321	202	48	al	al	PROPN
gs-4321	202	49	.	.	PROPN
gs-4321	202	50	,	,	PUNCT
gs-4321	202	51	2018	2018	NUM
gs-4321	202	52	;	;	PUNCT
gs-4321	202	53	wolf	wolf	PROPN
gs-4321	202	54	et	et	PROPN
gs-4321	202	55	al	al	PROPN
gs-4321	202	56	.	.	PROPN
gs-4321	202	57	,	,	PUNCT
gs-4321	202	58	2019	2019	NUM
gs-4321	202	59	)	)	PUNCT
gs-4321	202	60	.	.	PUNCT
gs-4321	203	1	these	these	DET
gs-4321	203	2	tools	tool	NOUN
gs-4321	203	3	reveal	reveal	VERB
gs-4321	203	4	that	that	SCONJ
gs-4321	203	5	malignant	malignant	ADJ
gs-4321	203	6	cells	cell	NOUN
gs-4321	203	7	frequently	frequently	ADV
gs-4321	203	8	exhibit	exhibit	VERB
gs-4321	203	9	bifurcating	bifurcate	VERB
gs-4321	203	10	decision	decision	NOUN
gs-4321	203	11	points	point	NOUN
gs-4321	203	12	,	,	PUNCT
gs-4321	203	13	where	where	SCONJ
gs-4321	203	14	populations	population	NOUN
gs-4321	203	15	can	can	AUX
gs-4321	203	16	diverge	diverge	VERB
gs-4321	203	17	toward	toward	ADP
gs-4321	203	18	either	either	CCONJ
gs-4321	203	19	proliferative	proliferative	ADJ
gs-4321	203	20	or	or	CCONJ
gs-4321	203	21	invasive	invasive	ADJ
gs-4321	203	22	phenotypes	phenotype	NOUN
gs-4321	203	23	.	.	PUNCT
gs-4321	204	1	identifying	identify	VERB
gs-4321	204	2	the	the	DET
gs-4321	204	3	regulators	regulator	NOUN
gs-4321	204	4	of	of	ADP
gs-4321	204	5	these	these	DET
gs-4321	204	6	branching	branch	VERB
gs-4321	204	7	events	event	NOUN
gs-4321	204	8	is	be	AUX
gs-4321	204	9	essential	essential	ADJ
gs-4321	204	10	for	for	ADP
gs-4321	204	11	predicting	predict	VERB
gs-4321	204	12	which	which	DET
gs-4321	204	13	subpopulations	subpopulation	NOUN
gs-4321	204	14	are	be	AUX
gs-4321	204	15	likely	likely	ADJ
gs-4321	204	16	to	to	PART
gs-4321	204	17	drive	drive	VERB
gs-4321	204	18	therapeutic	therapeutic	ADJ
gs-4321	204	19	resistance	resistance	NOUN
gs-4321	204	20	or	or	CCONJ
gs-4321	204	21	metastatic	metastatic	ADJ
gs-4321	204	22	dissemination	dissemination	NOUN
gs-4321	204	23	.	.	PUNCT
gs-4321	205	1	stem	stem	NOUN
gs-4321	205	2	-	-	PUNCT
gs-4321	205	3	associated	associate	VERB
gs-4321	205	4	intermediates	intermediate	NOUN
gs-4321	205	5	as	as	ADP
gs-4321	205	6	drivers	driver	NOUN
gs-4321	205	7	of	of	ADP
gs-4321	205	8	adaptation	adaptation	NOUN
gs-4321	205	9	intermediate	intermediate	ADJ
gs-4321	205	10	cellular	cellular	ADJ
gs-4321	205	11	states	state	NOUN
gs-4321	205	12	,	,	PUNCT
gs-4321	205	13	often	often	ADV
gs-4321	205	14	characterized	characterize	VERB
gs-4321	205	15	by	by	ADP
gs-4321	205	16	hybrid	hybrid	ADJ
gs-4321	205	17	epithelial	epithelial	ADJ
gs-4321	205	18	–	–	PUNCT
gs-4321	205	19	mesenchymal	mesenchymal	NOUN
gs-4321	205	20	(	(	PUNCT
gs-4321	205	21	e	e	NOUN
gs-4321	205	22	/	/	SYM
gs-4321	205	23	m	m	NOUN
gs-4321	205	24	)	)	PUNCT
gs-4321	205	25	phenotypes	phenotype	NOUN
gs-4321	205	26	,	,	PUNCT
gs-4321	205	27	play	play	VERB
gs-4321	205	28	a	a	DET
gs-4321	205	29	pivotal	pivotal	ADJ
gs-4321	205	30	role	role	NOUN
gs-4321	205	31	in	in	ADP
gs-4321	205	32	mediating	mediate	VERB
gs-4321	205	33	tumor	tumor	NOUN
gs-4321	205	34	adaptability	adaptability	NOUN
gs-4321	205	35	.	.	PUNCT
gs-4321	206	1	these	these	DET
gs-4321	206	2	states	state	NOUN
gs-4321	206	3	display	display	VERB
gs-4321	206	4	both	both	DET
gs-4321	206	5	stem	stem	NOUN
gs-4321	206	6	-	-	PUNCT
gs-4321	206	7	like	like	ADJ
gs-4321	206	8	characteristics	characteristic	NOUN
gs-4321	206	9	and	and	CCONJ
gs-4321	206	10	features	feature	NOUN
gs-4321	206	11	associated	associate	VERB
gs-4321	206	12	with	with	ADP
gs-4321	206	13	motility	motility	NOUN
gs-4321	206	14	,	,	PUNCT
gs-4321	206	15	enabling	enable	VERB
gs-4321	206	16	them	they	PRON
gs-4321	206	17	to	to	PART
gs-4321	206	18	contribute	contribute	VERB
gs-4321	206	19	to	to	ADP
gs-4321	206	20	metastatic	metastatic	ADJ
gs-4321	206	21	spread	spread	NOUN
gs-4321	206	22	and	and	CCONJ
gs-4321	206	23	therapeutic	therapeutic	ADJ
gs-4321	206	24	evasion	evasion	NOUN
gs-4321	206	25	(	(	PUNCT
gs-4321	206	26	pastushenko	pastushenko	NOUN
gs-4321	206	27	et	et	PROPN
gs-4321	206	28	al	al	PROPN
gs-4321	206	29	.	.	PROPN
gs-4321	206	30	,	,	PUNCT
gs-4321	206	31	2018	2018	NUM
gs-4321	206	32	)	)	PUNCT
gs-4321	206	33	.	.	PUNCT
gs-4321	207	1	bioinformatic	bioinformatic	ADJ
gs-4321	207	2	dissection	dissection	NOUN
gs-4321	207	3	of	of	ADP
gs-4321	207	4	hybrid	hybrid	ADJ
gs-4321	207	5	states	state	NOUN
gs-4321	207	6	using	use	VERB
gs-4321	207	7	single	single	ADJ
gs-4321	207	8	-	-	PUNCT
gs-4321	207	9	cell	cell	NOUN
gs-4321	207	10	methods	method	NOUN
gs-4321	207	11	has	have	AUX
gs-4321	207	12	shown	show	VERB
gs-4321	207	13	that	that	SCONJ
gs-4321	207	14	these	these	DET
gs-4321	207	15	cells	cell	NOUN
gs-4321	207	16	frequently	frequently	ADV
gs-4321	207	17	express	express	VERB
gs-4321	207	18	transcriptional	transcriptional	ADJ
gs-4321	207	19	signatures	signature	NOUN
gs-4321	207	20	associated	associate	VERB
gs-4321	207	21	with	with	ADP
gs-4321	207	22	stress	stress	NOUN
gs-4321	207	23	responses	response	NOUN
gs-4321	207	24	,	,	PUNCT
gs-4321	207	25	chromatin	chromatin	NOUN
gs-4321	207	26	remodeling	remodeling	NOUN
gs-4321	207	27	,	,	PUNCT
gs-4321	207	28	and	and	CCONJ
gs-4321	207	29	inflammatory	inflammatory	ADJ
gs-4321	207	30	signaling	signal	VERB
gs-4321	207	31	pathways	pathway	NOUN
gs-4321	207	32	.	.	PUNCT
gs-4321	208	1	their	their	PRON
gs-4321	208	2	existence	existence	NOUN
gs-4321	208	3	challenges	challenge	VERB
gs-4321	208	4	classical	classical	ADJ
gs-4321	208	5	binary	binary	ADJ
gs-4321	208	6	models	model	NOUN
gs-4321	208	7	of	of	ADP
gs-4321	208	8	cellular	cellular	ADJ
gs-4321	208	9	identity	identity	NOUN
gs-4321	208	10	by	by	ADP
gs-4321	208	11	demonstrating	demonstrate	VERB
gs-4321	208	12	that	that	SCONJ
gs-4321	208	13	malignant	malignant	ADJ
gs-4321	208	14	cells	cell	NOUN
gs-4321	208	15	occupy	occupy	VERB
gs-4321	208	16	a	a	DET
gs-4321	208	17	continuum	continuum	NOUN
gs-4321	208	18	of	of	ADP
gs-4321	208	19	phenotypes	phenotype	NOUN
gs-4321	208	20	shaped	shape	VERB
gs-4321	208	21	by	by	ADP
gs-4321	208	22	dynamic	dynamic	ADJ
gs-4321	208	23	regulatory	regulatory	ADJ
gs-4321	208	24	interplay	interplay	NOUN
gs-4321	208	25	.	.	PUNCT
gs-4321	209	1	these	these	DET
gs-4321	209	2	intermediate	intermediate	ADJ
gs-4321	209	3	states	state	NOUN
gs-4321	209	4	are	be	AUX
gs-4321	209	5	often	often	ADV
gs-4321	209	6	enriched	enrich	VERB
gs-4321	209	7	following	follow	VERB
gs-4321	209	8	therapeutic	therapeutic	ADJ
gs-4321	209	9	perturbations	perturbation	NOUN
gs-4321	209	10	.	.	PUNCT
gs-4321	210	1	for	for	ADP
gs-4321	210	2	example	example	NOUN
gs-4321	210	3	,	,	PUNCT
gs-4321	210	4	treatment	treatment	NOUN
gs-4321	210	5	-	-	PUNCT
gs-4321	210	6	resistant	resistant	ADJ
gs-4321	210	7	melanoma	melanoma	NOUN
gs-4321	210	8	cells	cell	NOUN
gs-4321	210	9	can	can	AUX
gs-4321	210	10	shift	shift	VERB
gs-4321	210	11	into	into	ADP
gs-4321	210	12	neural	neural	ADJ
gs-4321	210	13	crest	crest	NOUN
gs-4321	210	14	–	–	PUNCT
gs-4321	210	15	like	like	ADJ
gs-4321	210	16	or	or	CCONJ
gs-4321	210	17	invasive	invasive	ADJ
gs-4321	210	18	phenotypes	phenotype	NOUN
gs-4321	210	19	characterized	characterize	VERB
gs-4321	210	20	by	by	ADP
gs-4321	210	21	high	high	ADJ
gs-4321	210	22	plasticity	plasticity	NOUN
gs-4321	210	23	and	and	CCONJ
gs-4321	210	24	a	a	DET
gs-4321	210	25	unique	unique	ADJ
gs-4321	210	26	transcriptional	transcriptional	NOUN
gs-4321	210	27	program	program	NOUN
gs-4321	210	28	mediated	mediate	VERB
gs-4321	210	29	by	by	ADP
gs-4321	210	30	sox10	sox10	NOUN
gs-4321	210	31	,	,	PUNCT
gs-4321	210	32	nfatc2	nfatc2	PROPN
gs-4321	210	33	,	,	PUNCT
gs-4321	210	34	axl	axl	NOUN
gs-4321	210	35	,	,	PUNCT
gs-4321	210	36	and	and	CCONJ
gs-4321	210	37	ap-1	ap-1	ADP
gs-4321	210	38	components	component	NOUN
gs-4321	210	39	(	(	PUNCT
gs-4321	210	40	rambow	rambow	PROPN
gs-4321	210	41	et	et	PROPN
gs-4321	210	42	al	al	PROPN
gs-4321	210	43	.	.	PROPN
gs-4321	210	44	,	,	PUNCT
gs-4321	210	45	2018	2018	NUM
gs-4321	210	46	)	)	PUNCT
gs-4321	210	47	.	.	PUNCT
gs-4321	211	1	similar	similar	ADJ
gs-4321	211	2	adaptive	adaptive	ADJ
gs-4321	211	3	subpopulations	subpopulation	NOUN
gs-4321	211	4	have	have	AUX
gs-4321	211	5	been	be	AUX
gs-4321	211	6	observed	observe	VERB
gs-4321	211	7	in	in	ADP
gs-4321	211	8	lung	lung	NOUN
gs-4321	211	9	,	,	PUNCT
gs-4321	211	10	breast	breast	NOUN
gs-4321	211	11	,	,	PUNCT
gs-4321	211	12	and	and	CCONJ
gs-4321	211	13	pancreatic	pancreatic	ADJ
gs-4321	211	14	cancers	cancer	NOUN
gs-4321	211	15	,	,	PUNCT
gs-4321	211	16	suggesting	suggest	VERB
gs-4321	211	17	that	that	SCONJ
gs-4321	211	18	such	such	ADJ
gs-4321	211	19	transitions	transition	NOUN
gs-4321	211	20	represent	represent	VERB
gs-4321	211	21	a	a	DET
gs-4321	211	22	common	common	ADJ
gs-4321	211	23	mechanism	mechanism	NOUN
gs-4321	211	24	through	through	ADP
gs-4321	211	25	which	which	PRON
gs-4321	211	26	tumors	tumor	NOUN
gs-4321	211	27	reorganize	reorganize	VERB
gs-4321	211	28	cellular	cellular	ADJ
gs-4321	211	29	hierarchies	hierarchy	NOUN
gs-4321	211	30	under	under	ADP
gs-4321	211	31	selective	selective	ADJ
gs-4321	211	32	pressure	pressure	NOUN
gs-4321	211	33	.	.	PUNCT
gs-4321	212	1	inter	inter	ADJ
gs-4321	212	2	-	-	ADJ
gs-4321	212	3	clonal	clonal	ADJ
gs-4321	212	4	relationships	relationship	NOUN
gs-4321	212	5	and	and	CCONJ
gs-4321	212	6	evolutionary	evolutionary	ADJ
gs-4321	212	7	dynamics	dynamic	NOUN
gs-4321	212	8	in	in	ADP
gs-4321	212	9	addition	addition	NOUN
gs-4321	212	10	to	to	ADP
gs-4321	212	11	transcriptional	transcriptional	ADJ
gs-4321	212	12	heterogeneity	heterogeneity	NOUN
gs-4321	212	13	,	,	PUNCT
gs-4321	212	14	genetic	genetic	ADJ
gs-4321	212	15	diversification	diversification	NOUN
gs-4321	212	16	contributes	contribute	VERB
gs-4321	212	17	to	to	ADP
gs-4321	212	18	the	the	DET
gs-4321	212	19	complexity	complexity	NOUN
gs-4321	212	20	of	of	ADP
gs-4321	212	21	cancer	cancer	NOUN
gs-4321	212	22	cell	cell	NOUN
gs-4321	212	23	trajectories	trajectory	NOUN
gs-4321	212	24	.	.	PUNCT
gs-4321	213	1	single	single	ADJ
gs-4321	213	2	-	-	PUNCT
gs-4321	213	3	cell	cell	NOUN
gs-4321	213	4	dna	dna	NOUN
gs-4321	213	5	sequencing	sequencing	NOUN
gs-4321	213	6	and	and	CCONJ
gs-4321	213	7	lineage	lineage	NOUN
gs-4321	213	8	-	-	PUNCT
gs-4321	213	9	tracing	trace	VERB
gs-4321	213	10	approaches	approach	NOUN
gs-4321	213	11	have	have	AUX
gs-4321	213	12	revealed	reveal	VERB
gs-4321	213	13	that	that	SCONJ
gs-4321	213	14	tumors	tumor	NOUN
gs-4321	213	15	frequently	frequently	ADV
gs-4321	213	16	consist	consist	VERB
gs-4321	213	17	of	of	ADP
gs-4321	213	18	multiple	multiple	ADJ
gs-4321	213	19	genetically	genetically	ADV
gs-4321	213	20	distinct	distinct	ADJ
gs-4321	213	21	clones	clone	NOUN
gs-4321	213	22	that	that	PRON
gs-4321	213	23	follow	follow	VERB
gs-4321	213	24	divergent	divergent	ADJ
gs-4321	213	25	or	or	CCONJ
gs-4321	213	26	convergent	convergent	ADJ
gs-4321	213	27	evolutionary	evolutionary	ADJ
gs-4321	213	28	paths	path	NOUN
gs-4321	213	29	.	.	PUNCT
gs-4321	214	1	bioinformatic	bioinformatic	ADJ
gs-4321	214	2	tools	tool	NOUN
gs-4321	214	3	such	such	ADJ
gs-4321	214	4	as	as	ADP
gs-4321	214	5	georgian	georgian	NOUN
gs-4321	214	6	scientists/	scientists/	NUM
gs-4321	214	7	.	.	PUNCT
gs-4321	215	1	7	7	NUM
gs-4321	215	2	n	n	DET
gs-4321	215	3	4	4	NUM
gs-4321	215	4	,	,	PUNCT
gs-4321	215	5	2025	2025	NUM
gs-4321	215	6	346	346	NUM
gs-4321	215	7	phiscs	phisc	NOUN
gs-4321	215	8	,	,	PUNCT
gs-4321	215	9	scite	scite	PROPN
gs-4321	215	10	,	,	PUNCT
gs-4321	215	11	and	and	CCONJ
gs-4321	215	12	pyclone	pyclone	NOUN
gs-4321	215	13	have	have	AUX
gs-4321	215	14	been	be	AUX
gs-4321	215	15	applied	apply	VERB
gs-4321	215	16	to	to	PART
gs-4321	215	17	infer	infer	VERB
gs-4321	215	18	phylogenetic	phylogenetic	ADJ
gs-4321	215	19	relationships	relationship	NOUN
gs-4321	215	20	among	among	ADP
gs-4321	215	21	clones	clone	NOUN
gs-4321	215	22	,	,	PUNCT
gs-4321	215	23	offering	offer	VERB
gs-4321	215	24	insight	insight	NOUN
gs-4321	215	25	into	into	ADP
gs-4321	215	26	how	how	SCONJ
gs-4321	215	27	genetic	genetic	ADJ
gs-4321	215	28	and	and	CCONJ
gs-4321	215	29	transcriptional	transcriptional	ADJ
gs-4321	215	30	evolution	evolution	NOUN
gs-4321	215	31	intersect	intersect	ADJ
gs-4321	215	32	(	(	PUNCT
gs-4321	215	33	zafar	zafar	PROPN
gs-4321	215	34	et	et	PROPN
gs-4321	215	35	al	al	PROPN
gs-4321	215	36	.	.	PROPN
gs-4321	215	37	,	,	PUNCT
gs-4321	215	38	2019	2019	NUM
gs-4321	215	39	;	;	PUNCT
gs-4321	215	40	roth	roth	PROPN
gs-4321	215	41	et	et	PROPN
gs-4321	215	42	al	al	PROPN
gs-4321	215	43	.	.	PROPN
gs-4321	215	44	,	,	PUNCT
gs-4321	215	45	2014	2014	NUM
gs-4321	215	46	)	)	PUNCT
gs-4321	215	47	.	.	PUNCT
gs-4321	216	1	these	these	DET
gs-4321	216	2	analyses	analysis	NOUN
gs-4321	216	3	demonstrate	demonstrate	VERB
gs-4321	216	4	that	that	SCONJ
gs-4321	216	5	phenotypic	phenotypic	ADJ
gs-4321	216	6	plasticity	plasticity	NOUN
gs-4321	216	7	can	can	AUX
gs-4321	216	8	occur	occur	VERB
gs-4321	216	9	both	both	CCONJ
gs-4321	216	10	within	within	ADP
gs-4321	216	11	and	and	CCONJ
gs-4321	216	12	across	across	ADP
gs-4321	216	13	clonal	clonal	ADJ
gs-4321	216	14	boundaries	boundary	NOUN
gs-4321	216	15	,	,	PUNCT
gs-4321	216	16	highlighting	highlight	VERB
gs-4321	216	17	its	its	PRON
gs-4321	216	18	broad	broad	ADJ
gs-4321	216	19	relevance	relevance	NOUN
gs-4321	216	20	for	for	ADP
gs-4321	216	21	tumor	tumor	NOUN
gs-4321	216	22	adaptation	adaptation	NOUN
gs-4321	216	23	.	.	PUNCT
gs-4321	217	1	coupling	couple	VERB
gs-4321	217	2	evolutionary	evolutionary	ADJ
gs-4321	217	3	and	and	CCONJ
gs-4321	217	4	phenotypic	phenotypic	ADJ
gs-4321	217	5	landscapes	landscape	NOUN
gs-4321	217	6	the	the	DET
gs-4321	217	7	synthesis	synthesis	NOUN
gs-4321	217	8	of	of	ADP
gs-4321	217	9	genetic	genetic	ADJ
gs-4321	217	10	,	,	PUNCT
gs-4321	217	11	epigenetic	epigenetic	ADJ
gs-4321	217	12	,	,	PUNCT
gs-4321	217	13	and	and	CCONJ
gs-4321	217	14	transcriptional	transcriptional	ADJ
gs-4321	217	15	data	datum	NOUN
gs-4321	217	16	into	into	ADP
gs-4321	217	17	unified	unified	ADJ
gs-4321	217	18	evolutionary	evolutionary	ADJ
gs-4321	217	19	frameworks	framework	NOUN
gs-4321	217	20	represents	represent	VERB
gs-4321	217	21	an	an	DET
gs-4321	217	22	emerging	emerge	VERB
gs-4321	217	23	frontier	frontier	NOUN
gs-4321	217	24	in	in	ADP
gs-4321	217	25	single	single	ADJ
gs-4321	217	26	-	-	PUNCT
gs-4321	217	27	cell	cell	NOUN
gs-4321	217	28	computational	computational	ADJ
gs-4321	217	29	oncology	oncology	NOUN
gs-4321	217	30	.	.	PUNCT
gs-4321	218	1	by	by	ADP
gs-4321	218	2	overlaying	overlay	VERB
gs-4321	218	3	phenotypic	phenotypic	ADJ
gs-4321	218	4	information	information	NOUN
gs-4321	218	5	onto	onto	ADP
gs-4321	218	6	phylogenetic	phylogenetic	ADJ
gs-4321	218	7	trees	tree	NOUN
gs-4321	218	8	,	,	PUNCT
gs-4321	218	9	researchers	researcher	NOUN
gs-4321	218	10	can	can	AUX
gs-4321	218	11	identify	identify	VERB
gs-4321	218	12	whether	whether	SCONJ
gs-4321	218	13	stem	stem	VERB
gs-4321	218	14	-	-	PUNCT
gs-4321	218	15	like	like	ADJ
gs-4321	218	16	or	or	CCONJ
gs-4321	218	17	therapy	therapy	NOUN
gs-4321	218	18	-	-	PUNCT
gs-4321	218	19	resistant	resistant	ADJ
gs-4321	218	20	states	state	NOUN
gs-4321	218	21	emerge	emerge	VERB
gs-4321	218	22	preferentially	preferentially	ADV
gs-4321	218	23	from	from	ADP
gs-4321	218	24	specific	specific	ADJ
gs-4321	218	25	clones	clone	NOUN
gs-4321	218	26	or	or	CCONJ
gs-4321	218	27	whether	whether	SCONJ
gs-4321	218	28	they	they	PRON
gs-4321	218	29	arise	arise	VERB
gs-4321	218	30	across	across	ADP
gs-4321	218	31	diverse	diverse	ADJ
gs-4321	218	32	lineages	lineage	NOUN
gs-4321	218	33	.	.	PUNCT
gs-4321	219	1	such	such	ADJ
gs-4321	219	2	integrative	integrative	ADJ
gs-4321	219	3	analyses	analysis	NOUN
gs-4321	219	4	are	be	AUX
gs-4321	219	5	essential	essential	ADJ
gs-4321	219	6	for	for	ADP
gs-4321	219	7	determining	determine	VERB
gs-4321	219	8	how	how	SCONJ
gs-4321	219	9	evolutionary	evolutionary	ADJ
gs-4321	219	10	pressures	pressure	NOUN
gs-4321	219	11	sculpt	sculpt	ADJ
gs-4321	219	12	state	state	NOUN
gs-4321	219	13	distributions	distribution	NOUN
gs-4321	219	14	within	within	ADP
gs-4321	219	15	tumors	tumor	NOUN
gs-4321	219	16	.	.	PUNCT
gs-4321	220	1	gene	gene	NOUN
gs-4321	220	2	regulatory	regulatory	ADJ
gs-4321	220	3	networks	network	NOUN
gs-4321	220	4	governing	govern	VERB
gs-4321	220	5	adaptive	adaptive	ADJ
gs-4321	220	6	behaviors	behavior	NOUN
gs-4321	220	7	a	a	DET
gs-4321	220	8	central	central	ADJ
gs-4321	220	9	aim	aim	NOUN
gs-4321	220	10	of	of	ADP
gs-4321	220	11	modern	modern	ADJ
gs-4321	220	12	single	single	ADJ
gs-4321	220	13	-	-	PUNCT
gs-4321	220	14	cell	cell	NOUN
gs-4321	220	15	bioinformatics	bioinformatics	NOUN
gs-4321	220	16	is	be	AUX
gs-4321	220	17	to	to	PART
gs-4321	220	18	identify	identify	VERB
gs-4321	220	19	the	the	DET
gs-4321	220	20	transcriptional	transcriptional	ADJ
gs-4321	220	21	regulators	regulator	NOUN
gs-4321	220	22	and	and	CCONJ
gs-4321	220	23	gene	gene	NOUN
gs-4321	220	24	network	network	NOUN
gs-4321	220	25	structures	structure	NOUN
gs-4321	220	26	that	that	PRON
gs-4321	220	27	orchestrate	orchestrate	VERB
gs-4321	220	28	phenotypic	phenotypic	ADJ
gs-4321	220	29	transitions	transition	NOUN
gs-4321	220	30	in	in	ADP
gs-4321	220	31	malignant	malignant	ADJ
gs-4321	220	32	populations	population	NOUN
gs-4321	220	33	.	.	PUNCT
gs-4321	221	1	gene	gene	NOUN
gs-4321	221	2	regulatory	regulatory	ADJ
gs-4321	221	3	network	network	NOUN
gs-4321	221	4	(	(	PUNCT
gs-4321	221	5	grn	grn	PROPN
gs-4321	221	6	)	)	PUNCT
gs-4321	221	7	inference	inference	NOUN
gs-4321	221	8	tools	tool	NOUN
gs-4321	221	9	—	—	PUNCT
gs-4321	221	10	including	include	VERB
gs-4321	221	11	scenic	scenic	ADJ
gs-4321	221	12	,	,	PUNCT
gs-4321	221	13	bigscale	bigscale	NOUN
gs-4321	221	14	,	,	PUNCT
gs-4321	221	15	and	and	CCONJ
gs-4321	221	16	pidc	pidc	NOUN
gs-4321	221	17	—	—	PUNCT
gs-4321	221	18	enable	enable	ADJ
gs-4321	221	19	reconstruction	reconstruction	NOUN
gs-4321	221	20	of	of	ADP
gs-4321	221	21	transcription	transcription	NOUN
gs-4321	221	22	factor	factor	NOUN
gs-4321	221	23	–	–	PUNCT
gs-4321	221	24	target	target	NOUN
gs-4321	221	25	interactions	interaction	NOUN
gs-4321	221	26	based	base	VERB
gs-4321	221	27	on	on	ADP
gs-4321	221	28	coexpression	coexpression	NOUN
gs-4321	221	29	patterns	pattern	NOUN
gs-4321	221	30	and	and	CCONJ
gs-4321	221	31	motif	motif	NOUN
gs-4321	221	32	enrichment	enrichment	NOUN
gs-4321	221	33	across	across	ADP
gs-4321	221	34	thousands	thousand	NOUN
gs-4321	221	35	of	of	ADP
gs-4321	221	36	cells	cell	NOUN
gs-4321	221	37	(	(	PUNCT
gs-4321	221	38	aibar	aibar	NOUN
gs-4321	221	39	et	et	PROPN
gs-4321	221	40	al	al	PROPN
gs-4321	221	41	.	.	PROPN
gs-4321	221	42	,	,	PUNCT
gs-4321	221	43	2017	2017	NUM
gs-4321	221	44	;	;	PUNCT
gs-4321	221	45	iacono	iacono	NOUN
gs-4321	221	46	et	et	PROPN
gs-4321	221	47	al	al	PROPN
gs-4321	221	48	.	.	PROPN
gs-4321	221	49	,	,	PUNCT
gs-4321	221	50	2019	2019	NUM
gs-4321	221	51	)	)	PUNCT
gs-4321	221	52	.	.	PUNCT
gs-4321	222	1	these	these	DET
gs-4321	222	2	computational	computational	ADJ
gs-4321	222	3	approaches	approach	NOUN
gs-4321	222	4	have	have	AUX
gs-4321	222	5	revealed	reveal	VERB
gs-4321	222	6	that	that	SCONJ
gs-4321	222	7	adaptive	adaptive	ADJ
gs-4321	222	8	state	state	NOUN
gs-4321	222	9	transitions	transition	NOUN
gs-4321	222	10	frequently	frequently	ADV
gs-4321	222	11	arise	arise	VERB
gs-4321	222	12	from	from	ADP
gs-4321	222	13	the	the	DET
gs-4321	222	14	coordinated	coordinate	VERB
gs-4321	222	15	activation	activation	NOUN
gs-4321	222	16	of	of	ADP
gs-4321	222	17	multiple	multiple	ADJ
gs-4321	222	18	regulatory	regulatory	ADJ
gs-4321	222	19	modules	module	NOUN
gs-4321	222	20	rather	rather	ADV
gs-4321	222	21	than	than	ADP
gs-4321	222	22	single	single	ADJ
gs-4321	222	23	master	master	NOUN
gs-4321	222	24	regulators	regulator	NOUN
gs-4321	222	25	.	.	PUNCT
gs-4321	223	1	for	for	ADP
gs-4321	223	2	example	example	NOUN
gs-4321	223	3	,	,	PUNCT
gs-4321	223	4	stress	stress	NOUN
gs-4321	223	5	-	-	PUNCT
gs-4321	223	6	associated	associate	VERB
gs-4321	223	7	transcription	transcription	NOUN
gs-4321	223	8	factors	factor	NOUN
gs-4321	223	9	such	such	ADJ
gs-4321	223	10	as	as	ADP
gs-4321	223	11	jun	jun	PROPN
gs-4321	223	12	,	,	PUNCT
gs-4321	223	13	fos	fos	PROPN
gs-4321	223	14	,	,	PUNCT
gs-4321	223	15	stat3	stat3	NOUN
gs-4321	223	16	,	,	PUNCT
gs-4321	223	17	and	and	CCONJ
gs-4321	223	18	atf3	atf3	NOUN
gs-4321	223	19	often	often	ADV
gs-4321	223	20	act	act	VERB
gs-4321	223	21	together	together	ADV
gs-4321	223	22	to	to	PART
gs-4321	223	23	initiate	initiate	VERB
gs-4321	223	24	compensatory	compensatory	ADJ
gs-4321	223	25	programs	program	NOUN
gs-4321	223	26	that	that	PRON
gs-4321	223	27	support	support	VERB
gs-4321	223	28	survival	survival	NOUN
gs-4321	223	29	under	under	ADP
gs-4321	223	30	therapeutic	therapeutic	ADJ
gs-4321	223	31	pressure	pressure	NOUN
gs-4321	223	32	.	.	PUNCT
gs-4321	224	1	likewise	likewise	ADV
gs-4321	224	2	,	,	PUNCT
gs-4321	224	3	lineage	lineage	NOUN
gs-4321	224	4	-	-	PUNCT
gs-4321	224	5	specifying	specify	VERB
gs-4321	224	6	factors	factor	NOUN
gs-4321	224	7	such	such	ADJ
gs-4321	224	8	as	as	ADP
gs-4321	224	9	sox10	sox10	NOUN
gs-4321	224	10	,	,	PUNCT
gs-4321	224	11	mitf	mitf	NOUN
gs-4321	224	12	,	,	PUNCT
gs-4321	224	13	and	and	CCONJ
gs-4321	224	14	hes1	hes1	PROPN
gs-4321	224	15	shape	shape	NOUN
gs-4321	224	16	differentiation	differentiation	NOUN
gs-4321	224	17	trajectories	trajectory	NOUN
gs-4321	224	18	by	by	ADP
gs-4321	224	19	establishing	establish	VERB
gs-4321	224	20	chromatin	chromatin	NOUN
gs-4321	224	21	accessibility	accessibility	NOUN
gs-4321	224	22	landscapes	landscape	NOUN
gs-4321	224	23	that	that	PRON
gs-4321	224	24	permit	permit	VERB
gs-4321	224	25	or	or	CCONJ
gs-4321	224	26	restrict	restrict	VERB
gs-4321	224	27	downstream	downstream	ADJ
gs-4321	224	28	plasticity	plasticity	NOUN
gs-4321	224	29	.	.	PUNCT
gs-4321	225	1	the	the	DET
gs-4321	225	2	identification	identification	NOUN
gs-4321	225	3	of	of	ADP
gs-4321	225	4	such	such	ADJ
gs-4321	225	5	regulatory	regulatory	ADJ
gs-4321	225	6	determinants	determinant	NOUN
gs-4321	225	7	is	be	AUX
gs-4321	225	8	essential	essential	ADJ
gs-4321	225	9	for	for	ADP
gs-4321	225	10	understanding	understand	VERB
gs-4321	225	11	why	why	SCONJ
gs-4321	225	12	certain	certain	ADJ
gs-4321	225	13	subpopulations	subpopulation	NOUN
gs-4321	225	14	are	be	AUX
gs-4321	225	15	primed	prime	VERB
gs-4321	225	16	for	for	ADP
gs-4321	225	17	adaptability	adaptability	NOUN
gs-4321	225	18	while	while	SCONJ
gs-4321	225	19	others	other	NOUN
gs-4321	225	20	remain	remain	VERB
gs-4321	225	21	rigid	rigid	ADJ
gs-4321	225	22	.	.	PUNCT
gs-4321	226	1	grn	grn	PROPN
gs-4321	226	2	-	-	PUNCT
gs-4321	226	3	based	base	VERB
gs-4321	226	4	analyses	analysis	NOUN
gs-4321	226	5	have	have	AUX
gs-4321	226	6	shown	show	VERB
gs-4321	226	7	that	that	SCONJ
gs-4321	226	8	plastic	plastic	NOUN
gs-4321	226	9	,	,	PUNCT
gs-4321	226	10	stem	stem	NOUN
gs-4321	226	11	-	-	PUNCT
gs-4321	226	12	associated	associate	VERB
gs-4321	226	13	cells	cell	NOUN
gs-4321	226	14	typically	typically	ADV
gs-4321	226	15	exhibit	exhibit	VERB
gs-4321	226	16	higher	high	ADJ
gs-4321	226	17	transcriptional	transcriptional	NOUN
gs-4321	226	18	entropy	entropy	NOUN
gs-4321	226	19	—	—	PUNCT
gs-4321	226	20	an	an	DET
gs-4321	226	21	indicator	indicator	NOUN
gs-4321	226	22	of	of	ADP
gs-4321	226	23	regulatory	regulatory	ADJ
gs-4321	226	24	flexibility	flexibility	NOUN
gs-4321	226	25	—	—	PUNCT
gs-4321	226	26	compared	compare	VERB
gs-4321	226	27	to	to	ADP
gs-4321	226	28	more	more	ADV
gs-4321	226	29	committed	committed	ADJ
gs-4321	226	30	states	state	NOUN
gs-4321	226	31	(	(	PUNCT
gs-4321	226	32	teschendorff	teschendorff	NOUN
gs-4321	226	33	and	and	CCONJ
gs-4321	226	34	enver	enver	PROPN
gs-4321	226	35	,	,	PUNCT
gs-4321	226	36	2017	2017	NUM
gs-4321	226	37	)	)	PUNCT
gs-4321	226	38	.	.	PUNCT
gs-4321	227	1	this	this	DET
gs-4321	227	2	increased	increase	VERB
gs-4321	227	3	entropy	entropy	NOUN
gs-4321	227	4	reflects	reflect	VERB
gs-4321	227	5	a	a	DET
gs-4321	227	6	permissive	permissive	ADJ
gs-4321	227	7	regulatory	regulatory	ADJ
gs-4321	227	8	environment	environment	NOUN
gs-4321	227	9	that	that	PRON
gs-4321	227	10	enables	enable	VERB
gs-4321	227	11	rapid	rapid	ADJ
gs-4321	227	12	shifts	shift	NOUN
gs-4321	227	13	between	between	ADP
gs-4321	227	14	phenotypic	phenotypic	ADJ
gs-4321	227	15	configurations	configuration	NOUN
gs-4321	227	16	in	in	ADP
gs-4321	227	17	response	response	NOUN
gs-4321	227	18	to	to	ADP
gs-4321	227	19	changing	change	VERB
gs-4321	227	20	conditions	condition	NOUN
gs-4321	227	21	.	.	PUNCT
gs-4321	228	1	by	by	ADP
gs-4321	228	2	leveraging	leverage	VERB
gs-4321	228	3	grn	grn	PROPN
gs-4321	228	4	inference	inference	NOUN
gs-4321	228	5	,	,	PUNCT
gs-4321	228	6	researchers	researcher	NOUN
gs-4321	228	7	can	can	AUX
gs-4321	228	8	quantify	quantify	VERB
gs-4321	228	9	this	this	DET
gs-4321	228	10	regulatory	regulatory	ADJ
gs-4321	228	11	potential	potential	NOUN
gs-4321	228	12	and	and	CCONJ
gs-4321	228	13	pinpoint	pinpoint	VERB
gs-4321	228	14	the	the	DET
gs-4321	228	15	transcription	transcription	NOUN
gs-4321	228	16	factors	factor	VERB
gs-4321	228	17	most	most	ADV
gs-4321	228	18	responsible	responsible	ADJ
gs-4321	228	19	for	for	ADP
gs-4321	228	20	generating	generate	VERB
gs-4321	228	21	and	and	CCONJ
gs-4321	228	22	maintaining	maintain	VERB
gs-4321	228	23	adaptable	adaptable	ADJ
gs-4321	228	24	states	state	NOUN
gs-4321	228	25	.	.	PUNCT
gs-4321	229	1	georgian	georgian	NOUN
gs-4321	229	2	scientists/	scientists/	NUM
gs-4321	229	3	.	.	PUNCT
gs-4321	230	1	7	7	NUM
gs-4321	230	2	n	n	DET
gs-4321	230	3	4	4	NUM
gs-4321	230	4	,	,	PUNCT
gs-4321	230	5	2025	2025	NUM
gs-4321	230	6	347	347	NUM
gs-4321	230	7	figure	figure	NOUN
gs-4321	230	8	1	1	NUM
gs-4321	230	9	.	.	PUNCT
gs-4321	230	10	integrative	integrative	ADJ
gs-4321	230	11	multi	multi	ADJ
gs-4321	230	12	-	-	ADJ
gs-4321	230	13	layer	layer	ADJ
gs-4321	230	14	model	model	NOUN
gs-4321	230	15	of	of	ADP
gs-4321	230	16	adaptive	adaptive	ADJ
gs-4321	230	17	cellular	cellular	ADJ
gs-4321	230	18	states	state	NOUN
gs-4321	230	19	in	in	ADP
gs-4321	230	20	tumors	tumor	NOUN
gs-4321	230	21	caption	caption	NOUN
gs-4321	230	22	for	for	ADP
gs-4321	230	23	article	article	NOUN
gs-4321	230	24	:	:	PUNCT
gs-4321	230	25	this	this	DET
gs-4321	230	26	figure	figure	NOUN
gs-4321	230	27	illustrates	illustrate	VERB
gs-4321	230	28	the	the	DET
gs-4321	230	29	conceptual	conceptual	ADJ
gs-4321	230	30	framework	framework	NOUN
gs-4321	230	31	in	in	ADP
gs-4321	230	32	which	which	PRON
gs-4321	230	33	adaptive	adaptive	ADJ
gs-4321	230	34	cell	cell	NOUN
gs-4321	230	35	states	state	NOUN
gs-4321	230	36	in	in	ADP
gs-4321	230	37	tumors	tumor	NOUN
gs-4321	230	38	arise	arise	VERB
gs-4321	230	39	from	from	ADP
gs-4321	230	40	the	the	DET
gs-4321	230	41	integration	integration	NOUN
gs-4321	230	42	of	of	ADP
gs-4321	230	43	multiple	multiple	ADJ
gs-4321	230	44	regulatory	regulatory	ADJ
gs-4321	230	45	layers	layer	NOUN
gs-4321	230	46	.	.	PUNCT
gs-4321	231	1	the	the	DET
gs-4321	231	2	diagram	diagram	NOUN
gs-4321	231	3	includes	include	VERB
gs-4321	231	4	key	key	ADJ
gs-4321	231	5	components	component	NOUN
gs-4321	231	6	such	such	ADJ
gs-4321	231	7	as	as	ADP
gs-4321	231	8	transcriptional	transcriptional	ADJ
gs-4321	231	9	programs	program	NOUN
gs-4321	231	10	,	,	PUNCT
gs-4321	231	11	epigenetic	epigenetic	ADJ
gs-4321	231	12	remodeling	remodeling	NOUN
gs-4321	231	13	,	,	PUNCT
gs-4321	231	14	metabolic	metabolic	NOUN
gs-4321	231	15	reconfiguration	reconfiguration	NOUN
gs-4321	231	16	,	,	PUNCT
gs-4321	231	17	and	and	CCONJ
gs-4321	231	18	microenvironmental	microenvironmental	ADJ
gs-4321	231	19	cues	cue	NOUN
gs-4321	231	20	,	,	PUNCT
gs-4321	231	21	all	all	PRON
gs-4321	231	22	converging	converge	VERB
gs-4321	231	23	on	on	ADP
gs-4321	231	24	a	a	DET
gs-4321	231	25	central	central	ADJ
gs-4321	231	26	malignant	malignant	ADJ
gs-4321	231	27	cell	cell	NOUN
gs-4321	231	28	.	.	PUNCT
gs-4321	232	1	arrows	arrow	NOUN
gs-4321	232	2	indicate	indicate	VERB
gs-4321	232	3	the	the	DET
gs-4321	232	4	directional	directional	ADJ
gs-4321	232	5	influence	influence	NOUN
gs-4321	232	6	of	of	ADP
gs-4321	232	7	each	each	DET
gs-4321	232	8	regulatory	regulatory	ADJ
gs-4321	232	9	layer	layer	NOUN
gs-4321	232	10	on	on	ADP
gs-4321	232	11	cellular	cellular	ADJ
gs-4321	232	12	identity	identity	NOUN
gs-4321	232	13	and	and	CCONJ
gs-4321	232	14	phenotypic	phenotypic	ADJ
gs-4321	232	15	transitions	transition	NOUN
gs-4321	232	16	.	.	PUNCT
gs-4321	233	1	the	the	DET
gs-4321	233	2	model	model	NOUN
gs-4321	233	3	summarizes	summarize	VERB
gs-4321	233	4	how	how	SCONJ
gs-4321	233	5	multi	multi	ADJ
gs-4321	233	6	-	-	ADJ
gs-4321	233	7	omic	omic	ADJ
gs-4321	233	8	and	and	CCONJ
gs-4321	233	9	single	single	ADJ
gs-4321	233	10	-	-	PUNCT
gs-4321	233	11	cell	cell	NOUN
gs-4321	233	12	bioinformatic	bioinformatic	ADJ
gs-4321	233	13	approaches	approach	NOUN
gs-4321	233	14	can	can	AUX
gs-4321	233	15	be	be	AUX
gs-4321	233	16	combined	combine	VERB
gs-4321	233	17	to	to	PART
gs-4321	233	18	dissect	dissect	VERB
gs-4321	233	19	the	the	DET
gs-4321	233	20	mechanisms	mechanism	NOUN
gs-4321	233	21	underlying	underlie	VERB
gs-4321	233	22	cellular	cellular	ADJ
gs-4321	233	23	plasticity	plasticity	NOUN
gs-4321	233	24	in	in	ADP
gs-4321	233	25	cancer	cancer	NOUN
gs-4321	233	26	.	.	PUNCT
gs-4321	234	1	feedback	feedback	NOUN
gs-4321	234	2	loops	loop	NOUN
gs-4321	234	3	and	and	CCONJ
gs-4321	234	4	regulatory	regulatory	ADJ
gs-4321	234	5	architecture	architecture	NOUN
gs-4321	234	6	state	state	NOUN
gs-4321	234	7	transitions	transition	NOUN
gs-4321	234	8	in	in	ADP
gs-4321	234	9	malignant	malignant	ADJ
gs-4321	234	10	cells	cell	NOUN
gs-4321	234	11	are	be	AUX
gs-4321	234	12	often	often	ADV
gs-4321	234	13	reinforced	reinforce	VERB
gs-4321	234	14	by	by	ADP
gs-4321	234	15	feedback	feedback	NOUN
gs-4321	234	16	loops	loop	NOUN
gs-4321	234	17	that	that	PRON
gs-4321	234	18	stabilize	stabilize	VERB
gs-4321	234	19	newly	newly	ADV
gs-4321	234	20	adopted	adopt	VERB
gs-4321	234	21	phenotypes	phenotype	NOUN
gs-4321	234	22	or	or	CCONJ
gs-4321	234	23	facilitate	facilitate	VERB
gs-4321	234	24	reversible	reversible	ADJ
gs-4321	234	25	switching	switching	NOUN
gs-4321	234	26	.	.	PUNCT
gs-4321	235	1	positive	positive	ADJ
gs-4321	235	2	feedback	feedback	NOUN
gs-4321	235	3	loops	loop	NOUN
gs-4321	235	4	involving	involve	VERB
gs-4321	235	5	wnt	wnt	NOUN
gs-4321	235	6	–	–	PUNCT
gs-4321	235	7	-catenin	-catenin	NUM
gs-4321	235	8	,	,	PUNCT
gs-4321	235	9	nfb	nfb	NOUN
gs-4321	235	10	,	,	PUNCT
gs-4321	235	11	and	and	CCONJ
gs-4321	235	12	tgf	tgf	PROPN
gs-4321	235	13	pathways	pathway	NOUN
gs-4321	235	14	have	have	AUX
gs-4321	235	15	been	be	AUX
gs-4321	235	16	implicated	implicate	VERB
gs-4321	235	17	in	in	ADP
gs-4321	235	18	establishing	establish	VERB
gs-4321	235	19	and	and	CCONJ
gs-4321	235	20	maintaining	maintain	VERB
gs-4321	235	21	stem	stem	NOUN
gs-4321	235	22	-	-	PUNCT
gs-4321	235	23	like	like	ADJ
gs-4321	235	24	properties	property	NOUN
gs-4321	235	25	in	in	ADP
gs-4321	235	26	multiple	multiple	ADJ
gs-4321	235	27	cancers	cancer	NOUN
gs-4321	235	28	(	(	PUNCT
gs-4321	235	29	reya	reya	PROPN
gs-4321	235	30	and	and	CCONJ
gs-4321	235	31	clevers	clever	NOUN
gs-4321	235	32	,	,	PUNCT
gs-4321	235	33	2005	2005	NUM
gs-4321	235	34	;	;	PUNCT
gs-4321	235	35	batlle	batlle	NOUN
gs-4321	235	36	et	et	PROPN
gs-4321	235	37	al	al	PROPN
gs-4321	235	38	.	.	PROPN
gs-4321	235	39	,	,	PUNCT
gs-4321	235	40	2019	2019	NUM
gs-4321	235	41	)	)	PUNCT
gs-4321	235	42	.	.	PUNCT
gs-4321	236	1	conversely	conversely	ADV
gs-4321	236	2	,	,	PUNCT
gs-4321	236	3	negative	negative	ADJ
gs-4321	236	4	feedback	feedback	NOUN
gs-4321	236	5	circuits	circuit	NOUN
gs-4321	236	6	involving	involve	VERB
gs-4321	236	7	mapk	mapk	NOUN
gs-4321	236	8	signaling	signal	VERB
gs-4321	236	9	georgian	georgian	NOUN
gs-4321	236	10	scientists/	scientists/	NUM
gs-4321	236	11	.	.	PUNCT
gs-4321	237	1	7	7	NUM
gs-4321	237	2	n	n	DET
gs-4321	237	3	4	4	NUM
gs-4321	237	4	,	,	PUNCT
gs-4321	237	5	2025	2025	NUM
gs-4321	237	6	348	348	NUM
gs-4321	237	7	or	or	CCONJ
gs-4321	237	8	cell	cell	NOUN
gs-4321	237	9	-	-	PUNCT
gs-4321	237	10	cycle	cycle	NOUN
gs-4321	237	11	regulators	regulator	NOUN
gs-4321	237	12	can	can	AUX
gs-4321	237	13	act	act	VERB
gs-4321	237	14	as	as	ADP
gs-4321	237	15	brakes	brake	NOUN
gs-4321	237	16	that	that	PRON
gs-4321	237	17	limit	limit	VERB
gs-4321	237	18	uncontrolled	uncontrolled	ADJ
gs-4321	237	19	transitions	transition	NOUN
gs-4321	237	20	.	.	PUNCT
gs-4321	238	1	computational	computational	ADJ
gs-4321	238	2	modeling	modeling	NOUN
gs-4321	238	3	incorporating	incorporate	VERB
gs-4321	238	4	single	single	ADJ
gs-4321	238	5	-	-	PUNCT
gs-4321	238	6	cell	cell	NOUN
gs-4321	238	7	expression	expression	NOUN
gs-4321	238	8	data	datum	NOUN
gs-4321	238	9	has	have	AUX
gs-4321	238	10	begun	begin	VERB
gs-4321	238	11	to	to	PART
gs-4321	238	12	map	map	VERB
gs-4321	238	13	these	these	DET
gs-4321	238	14	feedback	feedback	NOUN
gs-4321	238	15	interactions	interaction	NOUN
gs-4321	238	16	with	with	ADP
gs-4321	238	17	increasing	increase	VERB
gs-4321	238	18	resolution	resolution	NOUN
gs-4321	238	19	.	.	PUNCT
gs-4321	239	1	such	such	ADJ
gs-4321	239	2	models	model	NOUN
gs-4321	239	3	reveal	reveal	VERB
gs-4321	239	4	that	that	SCONJ
gs-4321	239	5	adaptability	adaptability	NOUN
gs-4321	239	6	emerges	emerge	VERB
gs-4321	239	7	not	not	PART
gs-4321	239	8	simply	simply	ADV
gs-4321	239	9	from	from	ADP
gs-4321	239	10	elevated	elevated	ADJ
gs-4321	239	11	expression	expression	NOUN
gs-4321	239	12	of	of	ADP
gs-4321	239	13	certain	certain	ADJ
gs-4321	239	14	regulators	regulator	NOUN
gs-4321	239	15	but	but	CCONJ
gs-4321	239	16	from	from	ADP
gs-4321	239	17	a	a	DET
gs-4321	239	18	broader	broad	ADJ
gs-4321	239	19	network	network	NOUN
gs-4321	239	20	architecture	architecture	NOUN
gs-4321	239	21	that	that	PRON
gs-4321	239	22	promotes	promote	VERB
gs-4321	239	23	resilience	resilience	NOUN
gs-4321	239	24	and	and	CCONJ
gs-4321	239	25	flexibility	flexibility	NOUN
gs-4321	239	26	.	.	PUNCT
gs-4321	240	1	in	in	ADP
gs-4321	240	2	addition	addition	NOUN
gs-4321	240	3	to	to	ADP
gs-4321	240	4	intracellular	intracellular	ADJ
gs-4321	240	5	loops	loop	NOUN
gs-4321	240	6	,	,	PUNCT
gs-4321	240	7	feedback	feedback	NOUN
gs-4321	240	8	can	can	AUX
gs-4321	240	9	emerge	emerge	VERB
gs-4321	240	10	from	from	ADP
gs-4321	240	11	cell	cell	NOUN
gs-4321	240	12	–	–	PUNCT
gs-4321	240	13	cell	cell	NOUN
gs-4321	240	14	interactions	interaction	NOUN
gs-4321	240	15	.	.	PUNCT
gs-4321	241	1	for	for	ADP
gs-4321	241	2	example	example	NOUN
gs-4321	241	3	,	,	PUNCT
gs-4321	241	4	inflammatory	inflammatory	ADJ
gs-4321	241	5	cytokine	cytokine	NOUN
gs-4321	241	6	production	production	NOUN
gs-4321	241	7	by	by	ADP
gs-4321	241	8	immune	immune	ADJ
gs-4321	241	9	cells	cell	NOUN
gs-4321	241	10	can	can	AUX
gs-4321	241	11	induce	induce	VERB
gs-4321	241	12	adaptive	adaptive	ADJ
gs-4321	241	13	transcriptional	transcriptional	ADJ
gs-4321	241	14	programs	program	NOUN
gs-4321	241	15	in	in	ADP
gs-4321	241	16	malignant	malignant	ADJ
gs-4321	241	17	cells	cell	NOUN
gs-4321	241	18	,	,	PUNCT
gs-4321	241	19	which	which	PRON
gs-4321	241	20	in	in	ADP
gs-4321	241	21	turn	turn	NOUN
gs-4321	241	22	amplify	amplify	VERB
gs-4321	241	23	inflammatory	inflammatory	ADJ
gs-4321	241	24	signaling	signal	VERB
gs-4321	241	25	by	by	ADP
gs-4321	241	26	recruiting	recruit	VERB
gs-4321	241	27	or	or	CCONJ
gs-4321	241	28	reprogramming	reprogramme	VERB
gs-4321	241	29	additional	additional	ADJ
gs-4321	241	30	immune	immune	ADJ
gs-4321	241	31	populations	population	NOUN
gs-4321	241	32	(	(	PUNCT
gs-4321	241	33	grivennikov	grivennikov	PROPN
gs-4321	241	34	et	et	PROPN
gs-4321	241	35	al	al	PROPN
gs-4321	241	36	.	.	PROPN
gs-4321	241	37	,	,	PUNCT
gs-4321	241	38	2010	2010	NUM
gs-4321	241	39	)	)	PUNCT
gs-4321	241	40	.	.	PUNCT
gs-4321	242	1	single	single	ADJ
gs-4321	242	2	-	-	PUNCT
gs-4321	242	3	cell	cell	NOUN
gs-4321	242	4	communication	communication	NOUN
gs-4321	242	5	inference	inference	NOUN
gs-4321	242	6	tools	tool	NOUN
gs-4321	242	7	allow	allow	VERB
gs-4321	242	8	detailed	detailed	ADJ
gs-4321	242	9	characterization	characterization	NOUN
gs-4321	242	10	of	of	ADP
gs-4321	242	11	these	these	DET
gs-4321	242	12	reciprocal	reciprocal	ADJ
gs-4321	242	13	regulatory	regulatory	ADJ
gs-4321	242	14	loops	loop	NOUN
gs-4321	242	15	,	,	PUNCT
gs-4321	242	16	offering	offer	VERB
gs-4321	242	17	insight	insight	NOUN
gs-4321	242	18	into	into	ADP
gs-4321	242	19	how	how	SCONJ
gs-4321	242	20	tumors	tumor	NOUN
gs-4321	242	21	coordinate	coordinate	VERB
gs-4321	242	22	responses	response	NOUN
gs-4321	242	23	across	across	ADP
gs-4321	242	24	multiple	multiple	ADJ
gs-4321	242	25	compartments	compartment	NOUN
gs-4321	242	26	of	of	ADP
gs-4321	242	27	the	the	DET
gs-4321	242	28	microenvironment	microenvironment	NOUN
gs-4321	242	29	.	.	PUNCT
gs-4321	243	1	predictive	predictive	ADJ
gs-4321	243	2	modeling	modeling	NOUN
gs-4321	243	3	of	of	ADP
gs-4321	243	4	state	state	NOUN
gs-4321	243	5	transitions	transition	NOUN
gs-4321	243	6	advances	advance	NOUN
gs-4321	243	7	in	in	ADP
gs-4321	243	8	machine	machine	NOUN
gs-4321	243	9	learning	learning	NOUN
gs-4321	243	10	have	have	AUX
gs-4321	243	11	expanded	expand	VERB
gs-4321	243	12	the	the	DET
gs-4321	243	13	capacity	capacity	NOUN
gs-4321	243	14	to	to	PART
gs-4321	243	15	predict	predict	VERB
gs-4321	243	16	cellular	cellular	ADJ
gs-4321	243	17	trajectories	trajectory	NOUN
gs-4321	243	18	and	and	CCONJ
gs-4321	243	19	identify	identify	VERB
gs-4321	243	20	the	the	DET
gs-4321	243	21	regulators	regulator	NOUN
gs-4321	243	22	most	most	ADV
gs-4321	243	23	responsible	responsible	ADJ
gs-4321	243	24	for	for	ADP
gs-4321	243	25	directing	direct	VERB
gs-4321	243	26	state	state	NOUN
gs-4321	243	27	shifts	shift	NOUN
gs-4321	243	28	.	.	PUNCT
gs-4321	244	1	tools	tool	NOUN
gs-4321	244	2	such	such	ADJ
gs-4321	244	3	as	as	ADP
gs-4321	244	4	scvelo	scvelo	NOUN
gs-4321	244	5	,	,	PUNCT
gs-4321	244	6	fateid	fateid	NOUN
gs-4321	244	7	,	,	PUNCT
gs-4321	244	8	and	and	CCONJ
gs-4321	244	9	cellrank	cellrank	NOUN
gs-4321	244	10	integrate	integrate	VERB
gs-4321	244	11	transcriptomic	transcriptomic	ADJ
gs-4321	244	12	profiles	profile	NOUN
gs-4321	244	13	with	with	ADP
gs-4321	244	14	velocity	velocity	NOUN
gs-4321	244	15	-	-	PUNCT
gs-4321	244	16	based	base	VERB
gs-4321	244	17	estimations	estimation	NOUN
gs-4321	244	18	to	to	PART
gs-4321	244	19	generate	generate	VERB
gs-4321	244	20	probabilistic	probabilistic	ADJ
gs-4321	244	21	models	model	NOUN
gs-4321	244	22	of	of	ADP
gs-4321	244	23	future	future	ADJ
gs-4321	244	24	cellular	cellular	ADJ
gs-4321	244	25	states	state	NOUN
gs-4321	244	26	(	(	PUNCT
gs-4321	244	27	bergen	bergen	PROPN
gs-4321	244	28	et	et	PROPN
gs-4321	244	29	al	al	PROPN
gs-4321	244	30	.	.	PROPN
gs-4321	244	31	,	,	PUNCT
gs-4321	244	32	2020	2020	NUM
gs-4321	244	33	;	;	PUNCT
gs-4321	244	34	herman	herman	PROPN
gs-4321	244	35	et	et	PROPN
gs-4321	244	36	al	al	PROPN
gs-4321	244	37	.	.	PROPN
gs-4321	244	38	,	,	PUNCT
gs-4321	244	39	2020	2020	NUM
gs-4321	244	40	)	)	PUNCT
gs-4321	244	41	.	.	PUNCT
gs-4321	245	1	these	these	DET
gs-4321	245	2	predictive	predictive	ADJ
gs-4321	245	3	frameworks	framework	NOUN
gs-4321	245	4	enable	enable	VERB
gs-4321	245	5	identification	identification	NOUN
gs-4321	245	6	of	of	ADP
gs-4321	245	7	“	"	PUNCT
gs-4321	245	8	fate	fate	ADJ
gs-4321	245	9	determinants	determinant	NOUN
gs-4321	245	10	,	,	PUNCT
gs-4321	245	11	”	"	PUNCT
gs-4321	245	12	which	which	PRON
gs-4321	245	13	represent	represent	VERB
gs-4321	245	14	the	the	DET
gs-4321	245	15	factors	factor	NOUN
gs-4321	245	16	most	most	ADV
gs-4321	245	17	influential	influential	ADJ
gs-4321	245	18	in	in	ADP
gs-4321	245	19	guiding	guide	VERB
gs-4321	245	20	cells	cell	NOUN
gs-4321	245	21	toward	toward	ADP
gs-4321	245	22	particular	particular	ADJ
gs-4321	245	23	phenotypes	phenotype	NOUN
gs-4321	245	24	.	.	PUNCT
gs-4321	246	1	when	when	SCONJ
gs-4321	246	2	applied	apply	VERB
gs-4321	246	3	to	to	ADP
gs-4321	246	4	malignancies	malignancy	NOUN
gs-4321	246	5	,	,	PUNCT
gs-4321	246	6	such	such	ADJ
gs-4321	246	7	approaches	approach	NOUN
gs-4321	246	8	reveal	reveal	VERB
gs-4321	246	9	that	that	SCONJ
gs-4321	246	10	transitions	transition	NOUN
gs-4321	246	11	into	into	ADP
gs-4321	246	12	stem	stem	NOUN
gs-4321	246	13	-	-	PUNCT
gs-4321	246	14	like	like	ADJ
gs-4321	246	15	or	or	CCONJ
gs-4321	246	16	therapyresistant	therapyresistant	ADJ
gs-4321	246	17	states	state	NOUN
gs-4321	246	18	are	be	AUX
gs-4321	246	19	often	often	ADV
gs-4321	246	20	predictable	predictable	ADJ
gs-4321	246	21	,	,	PUNCT
gs-4321	246	22	governed	govern	VERB
gs-4321	246	23	by	by	ADP
gs-4321	246	24	early	early	ADJ
gs-4321	246	25	transcriptional	transcriptional	ADJ
gs-4321	246	26	priming	prime	VERB
gs-4321	246	27	events	event	NOUN
gs-4321	246	28	detectable	detectable	ADJ
gs-4321	246	29	before	before	SCONJ
gs-4321	246	30	overt	overt	ADJ
gs-4321	246	31	phenotypic	phenotypic	ADJ
gs-4321	246	32	changes	change	NOUN
gs-4321	246	33	occur	occur	VERB
gs-4321	246	34	.	.	PUNCT
gs-4321	247	1	predictive	predictive	ADJ
gs-4321	247	2	modeling	modeling	NOUN
gs-4321	247	3	thus	thus	ADV
gs-4321	247	4	offers	offer	VERB
gs-4321	247	5	powerful	powerful	ADJ
gs-4321	247	6	opportunities	opportunity	NOUN
gs-4321	247	7	for	for	ADP
gs-4321	247	8	developing	develop	VERB
gs-4321	247	9	biomarkers	biomarker	NOUN
gs-4321	247	10	capable	capable	ADJ
gs-4321	247	11	of	of	ADP
gs-4321	247	12	forecasting	forecast	VERB
gs-4321	247	13	therapeutic	therapeutic	ADJ
gs-4321	247	14	response	response	NOUN
gs-4321	247	15	or	or	CCONJ
gs-4321	247	16	disease	disease	NOUN
gs-4321	247	17	progression	progression	NOUN
gs-4321	247	18	.	.	PUNCT
gs-4321	248	1	moreover	moreover	ADV
gs-4321	248	2	,	,	PUNCT
gs-4321	248	3	by	by	ADP
gs-4321	248	4	identifying	identify	VERB
gs-4321	248	5	the	the	DET
gs-4321	248	6	transcription	transcription	NOUN
gs-4321	248	7	factors	factor	NOUN
gs-4321	248	8	or	or	CCONJ
gs-4321	248	9	pathways	pathway	NOUN
gs-4321	248	10	essential	essential	ADJ
gs-4321	248	11	for	for	ADP
gs-4321	248	12	state	state	NOUN
gs-4321	248	13	transitions	transition	NOUN
gs-4321	248	14	,	,	PUNCT
gs-4321	248	15	these	these	DET
gs-4321	248	16	analyses	analysis	NOUN
gs-4321	248	17	highlight	highlight	VERB
gs-4321	248	18	potential	potential	ADJ
gs-4321	248	19	therapeutic	therapeutic	ADJ
gs-4321	248	20	targets	target	NOUN
gs-4321	248	21	that	that	PRON
gs-4321	248	22	may	may	AUX
gs-4321	248	23	disrupt	disrupt	VERB
gs-4321	248	24	or	or	CCONJ
gs-4321	248	25	redirect	redirect	VERB
gs-4321	248	26	maladaptive	maladaptive	ADJ
gs-4321	248	27	trajectories	trajectory	NOUN
gs-4321	248	28	.	.	PUNCT
gs-4321	249	1	cell	cell	NOUN
gs-4321	249	2	–	–	PUNCT
gs-4321	249	3	cell	cell	NOUN
gs-4321	249	4	communication	communication	NOUN
gs-4321	249	5	networks	network	NOUN
gs-4321	249	6	shaping	shape	VERB
gs-4321	249	7	adaptive	adaptive	ADJ
gs-4321	249	8	states	state	NOUN
gs-4321	249	9	one	one	NUM
gs-4321	249	10	of	of	ADP
gs-4321	249	11	the	the	DET
gs-4321	249	12	most	most	ADV
gs-4321	249	13	influential	influential	ADJ
gs-4321	249	14	factors	factor	NOUN
gs-4321	249	15	shaping	shape	VERB
gs-4321	249	16	malignant	malignant	ADJ
gs-4321	249	17	cell	cell	NOUN
gs-4321	249	18	behavior	behavior	NOUN
gs-4321	249	19	is	be	AUX
gs-4321	249	20	the	the	DET
gs-4321	249	21	intricate	intricate	ADJ
gs-4321	249	22	network	network	NOUN
gs-4321	249	23	of	of	ADP
gs-4321	249	24	communication	communication	NOUN
gs-4321	249	25	signals	signal	NOUN
gs-4321	249	26	exchanged	exchange	VERB
gs-4321	249	27	between	between	ADP
gs-4321	249	28	tumor	tumor	NOUN
gs-4321	249	29	cells	cell	NOUN
gs-4321	249	30	and	and	CCONJ
gs-4321	249	31	their	their	PRON
gs-4321	249	32	surrounding	surround	VERB
gs-4321	249	33	microenvironment	microenvironment	NOUN
gs-4321	249	34	.	.	PUNCT
gs-4321	250	1	single	single	ADJ
gs-4321	250	2	-	-	PUNCT
gs-4321	250	3	cell	cell	NOUN
gs-4321	250	4	transcriptomics	transcriptomic	NOUN
gs-4321	250	5	,	,	PUNCT
gs-4321	250	6	combined	combine	VERB
gs-4321	250	7	with	with	ADP
gs-4321	250	8	computational	computational	ADJ
gs-4321	250	9	communication	communication	NOUN
gs-4321	250	10	inference	inference	NOUN
gs-4321	250	11	tools	tool	NOUN
gs-4321	250	12	such	such	ADJ
gs-4321	250	13	as	as	ADP
gs-4321	250	14	cellchat	cellchat	NOUN
gs-4321	250	15	,	,	PUNCT
gs-4321	250	16	nichenet	nichenet	NOUN
gs-4321	250	17	,	,	PUNCT
gs-4321	250	18	and	and	CCONJ
gs-4321	250	19	cellphonedb	cellphonedb	NOUN
gs-4321	250	20	,	,	PUNCT
gs-4321	250	21	has	have	AUX
gs-4321	250	22	enabled	enable	VERB
gs-4321	250	23	systematic	systematic	ADJ
gs-4321	250	24	identification	identification	NOUN
gs-4321	250	25	of	of	ADP
gs-4321	250	26	ligand	ligand	ADJ
gs-4321	250	27	–	–	PUNCT
gs-4321	250	28	receptor	receptor	NOUN
gs-4321	250	29	pairs	pair	NOUN
gs-4321	250	30	that	that	PRON
gs-4321	250	31	drive	drive	VERB
gs-4321	250	32	plasticity	plasticity	NOUN
gs-4321	250	33	in	in	ADP
gs-4321	250	34	various	various	ADJ
gs-4321	250	35	tumor	tumor	NOUN
gs-4321	250	36	types	type	NOUN
gs-4321	250	37	(	(	PUNCT
gs-4321	250	38	browaeys	browaey	NOUN
gs-4321	250	39	et	et	PROPN
gs-4321	250	40	al	al	PROPN
gs-4321	250	41	.	.	PROPN
gs-4321	250	42	,	,	PUNCT
gs-4321	250	43	2020	2020	NUM
gs-4321	250	44	;	;	PUNCT
gs-4321	250	45	efremova	efremova	PROPN
gs-4321	250	46	et	et	PROPN
gs-4321	250	47	al	al	PROPN
gs-4321	250	48	.	.	PROPN
gs-4321	250	49	,	,	PUNCT
gs-4321	250	50	2020	2020	NUM
gs-4321	250	51	)	)	PUNCT
gs-4321	250	52	.	.	PUNCT
gs-4321	251	1	these	these	DET
gs-4321	251	2	analyses	analysis	NOUN
gs-4321	251	3	demonstrate	demonstrate	VERB
gs-4321	251	4	that	that	SCONJ
gs-4321	251	5	cancer	cancer	NOUN
gs-4321	251	6	cells	cell	NOUN
gs-4321	251	7	frequently	frequently	ADV
gs-4321	251	8	rely	rely	VERB
gs-4321	251	9	on	on	ADP
gs-4321	251	10	signals	signal	NOUN
gs-4321	251	11	derived	derive	VERB
gs-4321	251	12	from	from	ADP
gs-4321	251	13	stromal	stromal	ADJ
gs-4321	251	14	fibroblasts	fibroblast	NOUN
gs-4321	251	15	,	,	PUNCT
gs-4321	251	16	macrophages	macrophage	NOUN
gs-4321	251	17	,	,	PUNCT
gs-4321	251	18	t	t	NOUN
gs-4321	251	19	cells	cell	NOUN
gs-4321	251	20	,	,	PUNCT
gs-4321	251	21	endothelial	endothelial	ADJ
gs-4321	251	22	cells	cell	NOUN
gs-4321	251	23	,	,	PUNCT
gs-4321	251	24	and	and	CCONJ
gs-4321	251	25	other	other	ADJ
gs-4321	251	26	niche	niche	NOUN
gs-4321	251	27	components	component	NOUN
gs-4321	251	28	to	to	PART
gs-4321	251	29	transition	transition	VERB
gs-4321	251	30	into	into	ADP
gs-4321	251	31	adaptive	adaptive	ADJ
gs-4321	251	32	states	state	NOUN
gs-4321	251	33	that	that	PRON
gs-4321	251	34	promote	promote	VERB
gs-4321	251	35	survival	survival	NOUN
gs-4321	251	36	and	and	CCONJ
gs-4321	251	37	metastasis	metastasis	NOUN
gs-4321	251	38	.	.	PUNCT
gs-4321	252	1	paracrine	paracrine	ADJ
gs-4321	252	2	signaling	signal	VERB
gs-4321	252	3	circuits	circuit	NOUN
gs-4321	252	4	,	,	PUNCT
gs-4321	252	5	including	include	VERB
gs-4321	252	6	tgf	tgf	PROPN
gs-4321	252	7	,	,	PUNCT
gs-4321	252	8	il-6	il-6	NOUN
gs-4321	252	9	/	/	SYM
gs-4321	252	10	stat3	stat3	NOUN
gs-4321	252	11	,	,	PUNCT
gs-4321	252	12	hgf	hgf	NOUN
gs-4321	252	13	/	/	PUNCT
gs-4321	252	14	met	meet	VERB
gs-4321	252	15	,	,	PUNCT
gs-4321	252	16	and	and	CCONJ
gs-4321	252	17	cxcl12	cxcl12	ADJ
gs-4321	252	18	/	/	SYM
gs-4321	252	19	cxcr4	cxcr4	NOUN
gs-4321	252	20	,	,	PUNCT
gs-4321	252	21	have	have	AUX
gs-4321	252	22	been	be	AUX
gs-4321	252	23	repeatedly	repeatedly	ADV
gs-4321	252	24	implicated	implicate	VERB
gs-4321	252	25	as	as	ADP
gs-4321	252	26	central	central	ADJ
gs-4321	252	27	regulators	regulator	NOUN
gs-4321	252	28	of	of	ADP
gs-4321	252	29	state	state	NOUN
gs-4321	252	30	georgian	georgian	NOUN
gs-4321	252	31	scientists/	scientists/	NUM
gs-4321	252	32	.	.	PUNCT
gs-4321	253	1	7	7	NUM
gs-4321	253	2	n	n	DET
gs-4321	253	3	4	4	NUM
gs-4321	253	4	,	,	PUNCT
gs-4321	253	5	2025	2025	NUM
gs-4321	253	6	349	349	NUM
gs-4321	253	7	interconversion	interconversion	NOUN
gs-4321	253	8	.	.	PUNCT
gs-4321	254	1	single	single	ADJ
gs-4321	254	2	-	-	PUNCT
gs-4321	254	3	cell	cell	NOUN
gs-4321	254	4	communication	communication	NOUN
gs-4321	254	5	models	model	NOUN
gs-4321	254	6	show	show	VERB
gs-4321	254	7	that	that	SCONJ
gs-4321	254	8	these	these	DET
gs-4321	254	9	signals	signal	NOUN
gs-4321	254	10	are	be	AUX
gs-4321	254	11	not	not	PART
gs-4321	254	12	uniformly	uniformly	ADV
gs-4321	254	13	distributed	distribute	VERB
gs-4321	254	14	but	but	CCONJ
gs-4321	254	15	instead	instead	ADV
gs-4321	254	16	are	be	AUX
gs-4321	254	17	concentrated	concentrate	VERB
gs-4321	254	18	within	within	ADP
gs-4321	254	19	specific	specific	ADJ
gs-4321	254	20	microenvironmental	microenvironmental	ADJ
gs-4321	254	21	niches	niche	NOUN
gs-4321	254	22	.	.	PUNCT
gs-4321	255	1	for	for	ADP
gs-4321	255	2	instance	instance	NOUN
gs-4321	255	3	,	,	PUNCT
gs-4321	255	4	il-6	il-6	NOUN
gs-4321	255	5	produced	produce	VERB
gs-4321	255	6	by	by	ADP
gs-4321	255	7	tumor	tumor	NOUN
gs-4321	255	8	-	-	PUNCT
gs-4321	255	9	associated	associate	VERB
gs-4321	255	10	macrophages	macrophage	NOUN
gs-4321	255	11	has	have	AUX
gs-4321	255	12	been	be	AUX
gs-4321	255	13	shown	show	VERB
gs-4321	255	14	to	to	PART
gs-4321	255	15	induce	induce	VERB
gs-4321	255	16	stem	stem	NOUN
gs-4321	255	17	-	-	PUNCT
gs-4321	255	18	associated	associate	VERB
gs-4321	255	19	programs	program	NOUN
gs-4321	255	20	in	in	ADP
gs-4321	255	21	breast	breast	NOUN
gs-4321	255	22	cancer	cancer	NOUN
gs-4321	255	23	cells	cell	NOUN
gs-4321	255	24	,	,	PUNCT
gs-4321	255	25	while	while	SCONJ
gs-4321	255	26	caf	caf	NOUN
gs-4321	255	27	-	-	PUNCT
gs-4321	255	28	derived	derive	VERB
gs-4321	255	29	tgf	tgf	PROPN
gs-4321	255	30	drives	drive	VERB
gs-4321	255	31	epithelial	epithelial	ADJ
gs-4321	255	32	–	–	PUNCT
gs-4321	255	33	mesenchymal	mesenchymal	ADJ
gs-4321	255	34	transition	transition	NOUN
gs-4321	255	35	and	and	CCONJ
gs-4321	255	36	promotes	promote	VERB
gs-4321	255	37	migration	migration	NOUN
gs-4321	255	38	(	(	PUNCT
gs-4321	255	39	carette	carette	NOUN
gs-4321	255	40	et	et	PROPN
gs-4321	255	41	al	al	PROPN
gs-4321	255	42	.	.	PROPN
gs-4321	255	43	,	,	PUNCT
gs-4321	255	44	2019	2019	NUM
gs-4321	255	45	;	;	PUNCT
gs-4321	255	46	glodde	glodde	VERB
gs-4321	255	47	et	et	PROPN
gs-4321	255	48	al	al	PROPN
gs-4321	255	49	.	.	PROPN
gs-4321	255	50	,	,	PUNCT
gs-4321	255	51	2017	2017	NUM
gs-4321	255	52	)	)	PUNCT
gs-4321	255	53	.	.	PUNCT
gs-4321	256	1	these	these	DET
gs-4321	256	2	interactions	interaction	NOUN
gs-4321	256	3	underscore	underscore	VERB
gs-4321	256	4	the	the	DET
gs-4321	256	5	importance	importance	NOUN
gs-4321	256	6	of	of	ADP
gs-4321	256	7	niche	niche	NOUN
gs-4321	256	8	-	-	PUNCT
gs-4321	256	9	specific	specific	ADJ
gs-4321	256	10	signals	signal	NOUN
gs-4321	256	11	in	in	ADP
gs-4321	256	12	shaping	shape	VERB
gs-4321	256	13	dynamic	dynamic	ADJ
gs-4321	256	14	cell	cell	NOUN
gs-4321	256	15	states	state	NOUN
gs-4321	256	16	and	and	CCONJ
gs-4321	256	17	demonstrate	demonstrate	VERB
gs-4321	256	18	why	why	SCONJ
gs-4321	256	19	computational	computational	ADJ
gs-4321	256	20	approaches	approach	NOUN
gs-4321	256	21	are	be	AUX
gs-4321	256	22	essential	essential	ADJ
gs-4321	256	23	for	for	ADP
gs-4321	256	24	resolving	resolve	VERB
gs-4321	256	25	the	the	DET
gs-4321	256	26	complexity	complexity	NOUN
gs-4321	256	27	of	of	ADP
gs-4321	256	28	multicellular	multicellular	ADJ
gs-4321	256	29	interactions	interaction	NOUN
gs-4321	256	30	.	.	PUNCT
gs-4321	257	1	immune	immune	ADJ
gs-4321	257	2	modulation	modulation	NOUN
gs-4321	257	3	of	of	ADP
gs-4321	257	4	plasticity	plasticity	NOUN
gs-4321	257	5	the	the	DET
gs-4321	257	6	immune	immune	ADJ
gs-4321	257	7	microenvironment	microenvironment	NOUN
gs-4321	257	8	exerts	exert	VERB
gs-4321	257	9	powerful	powerful	ADJ
gs-4321	257	10	selective	selective	ADJ
gs-4321	257	11	pressures	pressure	NOUN
gs-4321	257	12	that	that	PRON
gs-4321	257	13	shape	shape	VERB
gs-4321	257	14	malignant	malignant	ADJ
gs-4321	257	15	phenotypes	phenotype	NOUN
gs-4321	257	16	.	.	PUNCT
gs-4321	258	1	cytotoxic	cytotoxic	ADJ
gs-4321	258	2	t	t	NOUN
gs-4321	258	3	cells	cell	NOUN
gs-4321	258	4	can	can	AUX
gs-4321	258	5	induce	induce	VERB
gs-4321	258	6	dedifferentiation	dedifferentiation	NOUN
gs-4321	258	7	in	in	ADP
gs-4321	258	8	tumor	tumor	NOUN
gs-4321	258	9	cells	cell	NOUN
gs-4321	258	10	as	as	ADP
gs-4321	258	11	a	a	DET
gs-4321	258	12	means	means	NOUN
gs-4321	258	13	of	of	ADP
gs-4321	258	14	immune	immune	ADJ
gs-4321	258	15	evasion	evasion	NOUN
gs-4321	258	16	,	,	PUNCT
gs-4321	258	17	while	while	SCONJ
gs-4321	258	18	immunosuppressive	immunosuppressive	ADJ
gs-4321	258	19	myeloid	myeloid	ADJ
gs-4321	258	20	populations	population	NOUN
gs-4321	258	21	frequently	frequently	ADV
gs-4321	258	22	support	support	VERB
gs-4321	258	23	reprogramming	reprogramme	VERB
gs-4321	258	24	into	into	ADP
gs-4321	258	25	more	more	ADV
gs-4321	258	26	resilient	resilient	ADJ
gs-4321	258	27	states	state	NOUN
gs-4321	258	28	(	(	PUNCT
gs-4321	258	29	jerby	jerby	NOUN
gs-4321	258	30	-	-	PUNCT
gs-4321	258	31	arnon	arnon	PROPN
gs-4321	258	32	et	et	PROPN
gs-4321	258	33	al	al	PROPN
gs-4321	258	34	.	.	PROPN
gs-4321	258	35	,	,	PUNCT
gs-4321	258	36	2018	2018	NUM
gs-4321	258	37	;	;	PUNCT
gs-4321	258	38	kumar	kumar	PROPN
gs-4321	258	39	et	et	PROPN
gs-4321	258	40	al	al	PROPN
gs-4321	258	41	.	.	PROPN
gs-4321	258	42	,	,	PUNCT
gs-4321	258	43	2021	2021	NUM
gs-4321	258	44	)	)	PUNCT
gs-4321	258	45	.	.	PUNCT
gs-4321	259	1	single	single	ADJ
gs-4321	259	2	-	-	PUNCT
gs-4321	259	3	cell	cell	NOUN
gs-4321	259	4	immune	immune	ADJ
gs-4321	259	5	profiling	profiling	NOUN
gs-4321	259	6	,	,	PUNCT
gs-4321	259	7	combined	combine	VERB
gs-4321	259	8	with	with	ADP
gs-4321	259	9	trajectory	trajectory	NOUN
gs-4321	259	10	and	and	CCONJ
gs-4321	259	11	communication	communication	NOUN
gs-4321	259	12	analyses	analysis	NOUN
gs-4321	259	13	,	,	PUNCT
gs-4321	259	14	reveals	reveal	VERB
gs-4321	259	15	that	that	SCONJ
gs-4321	259	16	immune	immune	NOUN
gs-4321	259	17	-	-	PUNCT
gs-4321	259	18	inflicted	inflict	VERB
gs-4321	259	19	stress	stress	NOUN
gs-4321	259	20	often	often	ADV
gs-4321	259	21	initiates	initiate	VERB
gs-4321	259	22	transitions	transition	NOUN
gs-4321	259	23	toward	toward	ADP
gs-4321	259	24	stem	stem	NOUN
gs-4321	259	25	-	-	PUNCT
gs-4321	259	26	like	like	ADJ
gs-4321	259	27	or	or	CCONJ
gs-4321	259	28	therapytolerant	therapytolerant	ADJ
gs-4321	259	29	states	state	NOUN
gs-4321	259	30	.	.	PUNCT
gs-4321	260	1	this	this	DET
gs-4321	260	2	relationship	relationship	NOUN
gs-4321	260	3	is	be	AUX
gs-4321	260	4	bidirectional	bidirectional	ADJ
gs-4321	260	5	:	:	PUNCT
gs-4321	260	6	adaptive	adaptive	ADJ
gs-4321	260	7	malignant	malignant	ADJ
gs-4321	260	8	cells	cell	NOUN
gs-4321	260	9	can	can	AUX
gs-4321	260	10	alter	alter	VERB
gs-4321	260	11	cytokine	cytokine	ADJ
gs-4321	260	12	profiles	profile	NOUN
gs-4321	260	13	,	,	PUNCT
gs-4321	260	14	antigen	antigen	NOUN
gs-4321	260	15	expression	expression	NOUN
gs-4321	260	16	,	,	PUNCT
gs-4321	260	17	and	and	CCONJ
gs-4321	260	18	metabolic	metabolic	NOUN
gs-4321	260	19	outputs	output	NOUN
gs-4321	260	20	to	to	PART
gs-4321	260	21	modulate	modulate	VERB
gs-4321	260	22	immune	immune	ADJ
gs-4321	260	23	infiltration	infiltration	NOUN
gs-4321	260	24	,	,	PUNCT
gs-4321	260	25	shaping	shape	VERB
gs-4321	260	26	an	an	DET
gs-4321	260	27	environment	environment	NOUN
gs-4321	260	28	that	that	PRON
gs-4321	260	29	sustains	sustain	VERB
gs-4321	260	30	their	their	PRON
gs-4321	260	31	survival	survival	NOUN
gs-4321	260	32	.	.	PUNCT
gs-4321	261	1	communication	communication	NOUN
gs-4321	261	2	inference	inference	NOUN
gs-4321	261	3	tools	tool	NOUN
gs-4321	261	4	have	have	AUX
gs-4321	261	5	uncovered	uncover	VERB
gs-4321	261	6	several	several	ADJ
gs-4321	261	7	immune	immune	NOUN
gs-4321	261	8	-	-	PUNCT
gs-4321	261	9	driven	drive	VERB
gs-4321	261	10	feedback	feedback	NOUN
gs-4321	261	11	loops	loop	NOUN
gs-4321	261	12	that	that	PRON
gs-4321	261	13	enhance	enhance	VERB
gs-4321	261	14	plasticity	plasticity	NOUN
gs-4321	261	15	.	.	PUNCT
gs-4321	262	1	for	for	ADP
gs-4321	262	2	instance	instance	NOUN
gs-4321	262	3	,	,	PUNCT
gs-4321	262	4	ifn	ifn	PROPN
gs-4321	262	5	exposure	exposure	NOUN
gs-4321	262	6	can	can	AUX
gs-4321	262	7	drive	drive	VERB
gs-4321	262	8	reversible	reversible	ADJ
gs-4321	262	9	dedifferentiation	dedifferentiation	NOUN
gs-4321	262	10	in	in	ADP
gs-4321	262	11	melanoma	melanoma	NOUN
gs-4321	262	12	,	,	PUNCT
gs-4321	262	13	producing	produce	VERB
gs-4321	262	14	a	a	DET
gs-4321	262	15	cell	cell	NOUN
gs-4321	262	16	state	state	NOUN
gs-4321	262	17	that	that	PRON
gs-4321	262	18	is	be	AUX
gs-4321	262	19	less	less	ADV
gs-4321	262	20	immunogenic	immunogenic	ADJ
gs-4321	262	21	but	but	CCONJ
gs-4321	262	22	more	more	ADV
gs-4321	262	23	resistant	resistant	ADJ
gs-4321	262	24	to	to	ADP
gs-4321	262	25	therapy	therapy	NOUN
gs-4321	262	26	(	(	PUNCT
gs-4321	262	27	benci	benci	PROPN
gs-4321	262	28	et	et	PROPN
gs-4321	262	29	al	al	PROPN
gs-4321	262	30	.	.	PROPN
gs-4321	262	31	,	,	PUNCT
gs-4321	262	32	2016	2016	NUM
gs-4321	262	33	)	)	PUNCT
gs-4321	262	34	.	.	PUNCT
gs-4321	263	1	such	such	ADJ
gs-4321	263	2	findings	finding	NOUN
gs-4321	263	3	illustrate	illustrate	VERB
gs-4321	263	4	that	that	SCONJ
gs-4321	263	5	plasticity	plasticity	NOUN
gs-4321	263	6	is	be	AUX
gs-4321	263	7	not	not	PART
gs-4321	263	8	solely	solely	ADV
gs-4321	263	9	a	a	DET
gs-4321	263	10	response	response	NOUN
gs-4321	263	11	to	to	ADP
gs-4321	263	12	therapeutic	therapeutic	ADJ
gs-4321	263	13	stimuli	stimulus	NOUN
gs-4321	263	14	but	but	CCONJ
gs-4321	263	15	is	be	AUX
gs-4321	263	16	also	also	ADV
gs-4321	263	17	shaped	shape	VERB
gs-4321	263	18	by	by	ADP
gs-4321	263	19	immune	immune	NOUN
gs-4321	263	20	-	-	PUNCT
gs-4321	263	21	mediated	mediate	VERB
gs-4321	263	22	selective	selective	ADJ
gs-4321	263	23	forces	force	NOUN
gs-4321	263	24	.	.	PUNCT
gs-4321	264	1	spatially	spatially	ADV
gs-4321	264	2	resolved	resolve	VERB
gs-4321	264	3	communication	communication	NOUN
gs-4321	264	4	and	and	CCONJ
gs-4321	264	5	local	local	ADJ
gs-4321	264	6	niches	niche	NOUN
gs-4321	264	7	spatial	spatial	ADJ
gs-4321	264	8	transcriptomic	transcriptomic	ADJ
gs-4321	264	9	technologies	technology	NOUN
gs-4321	264	10	have	have	VERB
gs-4321	264	11	further	far	ADV
gs-4321	264	12	advanced	advanced	ADJ
gs-4321	264	13	understanding	understanding	NOUN
gs-4321	264	14	of	of	ADP
gs-4321	264	15	communication	communication	NOUN
gs-4321	264	16	networks	network	NOUN
gs-4321	264	17	by	by	ADP
gs-4321	264	18	enabling	enable	VERB
gs-4321	264	19	localization	localization	NOUN
gs-4321	264	20	of	of	ADP
gs-4321	264	21	ligand	ligand	ADJ
gs-4321	264	22	–	–	PUNCT
gs-4321	264	23	receptor	receptor	NOUN
gs-4321	264	24	interactions	interaction	NOUN
gs-4321	264	25	within	within	ADP
gs-4321	264	26	defined	define	VERB
gs-4321	264	27	tissue	tissue	NOUN
gs-4321	264	28	regions	region	NOUN
gs-4321	264	29	.	.	PUNCT
gs-4321	265	1	hypoxic	hypoxic	ADJ
gs-4321	265	2	areas	area	NOUN
gs-4321	265	3	,	,	PUNCT
gs-4321	265	4	perivascular	perivascular	ADJ
gs-4321	265	5	zones	zone	NOUN
gs-4321	265	6	,	,	PUNCT
gs-4321	265	7	and	and	CCONJ
gs-4321	265	8	immune	immune	NOUN
gs-4321	265	9	-	-	PUNCT
gs-4321	265	10	infiltrated	infiltrate	VERB
gs-4321	265	11	microdomains	microdomain	NOUN
gs-4321	265	12	frequently	frequently	ADV
gs-4321	265	13	harbor	harbor	VERB
gs-4321	265	14	distinct	distinct	ADJ
gs-4321	265	15	communication	communication	NOUN
gs-4321	265	16	signatures	signature	NOUN
gs-4321	265	17	that	that	PRON
gs-4321	265	18	correlate	correlate	VERB
gs-4321	265	19	with	with	ADP
gs-4321	265	20	increased	increase	VERB
gs-4321	265	21	adaptability	adaptability	NOUN
gs-4321	265	22	or	or	CCONJ
gs-4321	265	23	therapeutic	therapeutic	ADJ
gs-4321	265	24	resistance	resistance	NOUN
gs-4321	265	25	(	(	PUNCT
gs-4321	265	26	jensen	jensen	PROPN
gs-4321	265	27	et	et	PROPN
gs-4321	265	28	al	al	PROPN
gs-4321	265	29	.	.	PROPN
gs-4321	265	30	,	,	PUNCT
gs-4321	265	31	2021	2021	NUM
gs-4321	265	32	)	)	PUNCT
gs-4321	265	33	.	.	PUNCT
gs-4321	266	1	integrating	integrate	VERB
gs-4321	266	2	spatial	spatial	ADJ
gs-4321	266	3	and	and	CCONJ
gs-4321	266	4	single	single	ADJ
gs-4321	266	5	-	-	PUNCT
gs-4321	266	6	cell	cell	NOUN
gs-4321	266	7	datasets	dataset	NOUN
gs-4321	266	8	via	via	ADP
gs-4321	266	9	computational	computational	ADJ
gs-4321	266	10	frameworks	framework	NOUN
gs-4321	266	11	such	such	ADJ
gs-4321	266	12	as	as	ADP
gs-4321	266	13	spaotsc	spaotsc	NOUN
gs-4321	266	14	or	or	CCONJ
gs-4321	266	15	seurat	seurat	PROPN
gs-4321	266	16	’s	’s	PART
gs-4321	266	17	spatial	spatial	ADJ
gs-4321	266	18	modules	module	NOUN
gs-4321	266	19	allows	allow	VERB
gs-4321	266	20	identification	identification	NOUN
gs-4321	266	21	of	of	ADP
gs-4321	266	22	microenvironmental	microenvironmental	ADJ
gs-4321	266	23	“	"	PUNCT
gs-4321	266	24	ecosystem	ecosystem	NOUN
gs-4321	266	25	hubs	hub	NOUN
gs-4321	266	26	”	"	PUNCT
gs-4321	266	27	where	where	SCONJ
gs-4321	266	28	communication	communication	NOUN
gs-4321	266	29	networks	network	NOUN
gs-4321	266	30	converge	converge	VERB
gs-4321	266	31	to	to	PART
gs-4321	266	32	promote	promote	VERB
gs-4321	266	33	adaptive	adaptive	ADJ
gs-4321	266	34	transitions	transition	NOUN
gs-4321	266	35	.	.	PUNCT
gs-4321	267	1	these	these	DET
gs-4321	267	2	spatial	spatial	ADJ
gs-4321	267	3	analyses	analysis	NOUN
gs-4321	267	4	highlight	highlight	VERB
gs-4321	267	5	that	that	SCONJ
gs-4321	267	6	state	state	NOUN
gs-4321	267	7	interconversion	interconversion	NOUN
gs-4321	267	8	is	be	AUX
gs-4321	267	9	not	not	PART
gs-4321	267	10	uniform	uniform	ADJ
gs-4321	267	11	throughout	throughout	ADP
gs-4321	267	12	the	the	DET
gs-4321	267	13	tumor	tumor	NOUN
gs-4321	267	14	but	but	CCONJ
gs-4321	267	15	is	be	AUX
gs-4321	267	16	often	often	ADV
gs-4321	267	17	restricted	restrict	VERB
gs-4321	267	18	to	to	ADP
gs-4321	267	19	microdomains	microdomain	NOUN
gs-4321	267	20	where	where	SCONJ
gs-4321	267	21	niche	niche	NOUN
gs-4321	267	22	-	-	PUNCT
gs-4321	267	23	derived	derive	VERB
gs-4321	267	24	cues	cue	NOUN
gs-4321	267	25	align	align	VERB
gs-4321	267	26	to	to	ADP
gs-4321	267	27	prime	prime	ADJ
gs-4321	267	28	cells	cell	NOUN
gs-4321	267	29	for	for	ADP
gs-4321	267	30	plasticity	plasticity	NOUN
gs-4321	267	31	.	.	PUNCT
gs-4321	268	1	understanding	understand	VERB
gs-4321	268	2	these	these	DET
gs-4321	268	3	localized	localized	ADJ
gs-4321	268	4	environments	environment	NOUN
gs-4321	268	5	is	be	AUX
gs-4321	268	6	essential	essential	ADJ
gs-4321	268	7	for	for	ADP
gs-4321	268	8	developing	develop	VERB
gs-4321	268	9	precision	precision	NOUN
gs-4321	268	10	strategies	strategy	NOUN
gs-4321	268	11	that	that	PRON
gs-4321	268	12	target	target	VERB
gs-4321	268	13	the	the	DET
gs-4321	268	14	ecological	ecological	ADJ
gs-4321	268	15	determinants	determinant	NOUN
gs-4321	268	16	of	of	ADP
gs-4321	268	17	malignant	malignant	ADJ
gs-4321	268	18	behavior	behavior	NOUN
gs-4321	268	19	.	.	PUNCT
gs-4321	269	1	georgian	georgian	NOUN
gs-4321	269	2	scientists/	scientists/	NUM
gs-4321	269	3	.	.	PUNCT
gs-4321	270	1	7	7	NUM
gs-4321	270	2	n	n	DET
gs-4321	270	3	4	4	NUM
gs-4321	270	4	,	,	PUNCT
gs-4321	270	5	2025	2025	NUM
gs-4321	270	6	350	350	NUM
gs-4321	270	7	integration	integration	NOUN
gs-4321	270	8	of	of	ADP
gs-4321	270	9	multimodal	multimodal	ADJ
gs-4321	270	10	single	single	ADJ
gs-4321	270	11	-	-	PUNCT
gs-4321	270	12	cell	cell	NOUN
gs-4321	270	13	technologies	technology	NOUN
gs-4321	270	14	as	as	ADP
gs-4321	270	15	single	single	ADJ
gs-4321	270	16	-	-	PUNCT
gs-4321	270	17	cell	cell	NOUN
gs-4321	270	18	technologies	technology	NOUN
gs-4321	270	19	continue	continue	VERB
gs-4321	270	20	to	to	PART
gs-4321	270	21	expand	expand	VERB
gs-4321	270	22	,	,	PUNCT
gs-4321	270	23	multimodal	multimodal	ADJ
gs-4321	270	24	profiling	profiling	NOUN
gs-4321	270	25	has	have	AUX
gs-4321	270	26	emerged	emerge	VERB
gs-4321	270	27	as	as	ADP
gs-4321	270	28	a	a	DET
gs-4321	270	29	transformative	transformative	ADJ
gs-4321	270	30	approach	approach	NOUN
gs-4321	270	31	for	for	ADP
gs-4321	270	32	characterizing	characterize	VERB
gs-4321	270	33	the	the	DET
gs-4321	270	34	molecular	molecular	ADJ
gs-4321	270	35	architecture	architecture	NOUN
gs-4321	270	36	underlying	underlie	VERB
gs-4321	270	37	phenotypic	phenotypic	ADJ
gs-4321	270	38	adaptability	adaptability	NOUN
gs-4321	270	39	.	.	PUNCT
gs-4321	271	1	techniques	technique	NOUN
gs-4321	271	2	such	such	ADJ
gs-4321	271	3	as	as	ADP
gs-4321	271	4	cite	cite	NOUN
gs-4321	271	5	-	-	PUNCT
gs-4321	271	6	seq	seq	NOUN
gs-4321	271	7	,	,	PUNCT
gs-4321	271	8	reap	reap	NOUN
gs-4321	271	9	-	-	PUNCT
gs-4321	271	10	seq	seq	NOUN
gs-4321	271	11	,	,	PUNCT
gs-4321	271	12	share	share	NOUN
gs-4321	271	13	-	-	PUNCT
gs-4321	271	14	seq	seq	NOUN
gs-4321	271	15	,	,	PUNCT
gs-4321	271	16	and	and	CCONJ
gs-4321	271	17	scatac	scatac	ADJ
gs-4321	271	18	–	–	PUNCT
gs-4321	271	19	scrna	scrna	NOUN
gs-4321	271	20	joint	joint	ADJ
gs-4321	271	21	profiling	profiling	NOUN
gs-4321	271	22	permit	permit	NOUN
gs-4321	271	23	simultaneous	simultaneous	ADJ
gs-4321	271	24	measurement	measurement	NOUN
gs-4321	271	25	of	of	ADP
gs-4321	271	26	transcriptomic	transcriptomic	ADJ
gs-4321	271	27	,	,	PUNCT
gs-4321	271	28	epigenomic	epigenomic	ADJ
gs-4321	271	29	,	,	PUNCT
gs-4321	271	30	and	and	CCONJ
gs-4321	271	31	proteomic	proteomic	ADJ
gs-4321	271	32	features	feature	NOUN
gs-4321	271	33	within	within	ADP
gs-4321	271	34	the	the	DET
gs-4321	271	35	same	same	ADJ
gs-4321	271	36	cell	cell	NOUN
gs-4321	271	37	(	(	PUNCT
gs-4321	271	38	stoeckius	stoeckius	PROPN
gs-4321	271	39	et	et	PROPN
gs-4321	271	40	al	al	PROPN
gs-4321	271	41	.	.	PROPN
gs-4321	271	42	,	,	PUNCT
gs-4321	271	43	2017	2017	NUM
gs-4321	271	44	;	;	PUNCT
gs-4321	271	45	ma	ma	PROPN
gs-4321	271	46	et	et	PROPN
gs-4321	271	47	al	al	PROPN
gs-4321	271	48	.	.	PROPN
gs-4321	271	49	,	,	PUNCT
gs-4321	271	50	2020	2020	NUM
gs-4321	271	51	)	)	PUNCT
gs-4321	271	52	.	.	PUNCT
gs-4321	272	1	these	these	DET
gs-4321	272	2	methods	method	NOUN
gs-4321	272	3	provide	provide	VERB
gs-4321	272	4	a	a	DET
gs-4321	272	5	multidimensional	multidimensional	ADJ
gs-4321	272	6	view	view	NOUN
gs-4321	272	7	of	of	ADP
gs-4321	272	8	cellular	cellular	ADJ
gs-4321	272	9	identity	identity	NOUN
gs-4321	272	10	,	,	PUNCT
gs-4321	272	11	revealing	reveal	VERB
gs-4321	272	12	how	how	SCONJ
gs-4321	272	13	regulatory	regulatory	ADJ
gs-4321	272	14	layers	layer	NOUN
gs-4321	272	15	interact	interact	VERB
gs-4321	272	16	to	to	PART
gs-4321	272	17	enable	enable	VERB
gs-4321	272	18	transitions	transition	NOUN
gs-4321	272	19	between	between	ADP
gs-4321	272	20	functional	functional	ADJ
gs-4321	272	21	states	state	NOUN
gs-4321	272	22	.	.	PUNCT
gs-4321	273	1	for	for	ADP
gs-4321	273	2	example	example	NOUN
gs-4321	273	3	,	,	PUNCT
gs-4321	273	4	joint	joint	ADJ
gs-4321	273	5	atac	atac	NOUN
gs-4321	273	6	–	–	PUNCT
gs-4321	273	7	rna	rna	NOUN
gs-4321	273	8	profiling	profiling	NOUN
gs-4321	273	9	has	have	AUX
gs-4321	273	10	shown	show	VERB
gs-4321	273	11	that	that	SCONJ
gs-4321	273	12	chromatin	chromatin	NOUN
gs-4321	273	13	priming	priming	NOUN
gs-4321	273	14	frequently	frequently	ADV
gs-4321	273	15	precedes	precede	VERB
gs-4321	273	16	transcriptional	transcriptional	ADJ
gs-4321	273	17	changes	change	NOUN
gs-4321	273	18	during	during	ADP
gs-4321	273	19	dedifferentiation	dedifferentiation	NOUN
gs-4321	273	20	or	or	CCONJ
gs-4321	273	21	therapy	therapy	NOUN
gs-4321	273	22	-	-	PUNCT
gs-4321	273	23	induced	induce	VERB
gs-4321	273	24	plasticity	plasticity	NOUN
gs-4321	273	25	,	,	PUNCT
gs-4321	273	26	suggesting	suggest	VERB
gs-4321	273	27	that	that	SCONJ
gs-4321	273	28	epigenetic	epigenetic	ADJ
gs-4321	273	29	readiness	readiness	NOUN
gs-4321	273	30	determines	determine	VERB
gs-4321	273	31	the	the	DET
gs-4321	273	32	direction	direction	NOUN
gs-4321	273	33	of	of	ADP
gs-4321	273	34	trajectory	trajectory	NOUN
gs-4321	273	35	shifts	shift	NOUN
gs-4321	273	36	(	(	PUNCT
gs-4321	273	37	ma	ma	PROPN
gs-4321	273	38	et	et	PROPN
gs-4321	273	39	al	al	PROPN
gs-4321	273	40	.	.	PROPN
gs-4321	273	41	,	,	PUNCT
gs-4321	273	42	2020	2020	NUM
gs-4321	273	43	)	)	PUNCT
gs-4321	273	44	.	.	PUNCT
gs-4321	274	1	computational	computational	ADJ
gs-4321	274	2	frameworks	framework	NOUN
gs-4321	274	3	such	such	ADJ
gs-4321	274	4	as	as	ADP
gs-4321	274	5	mofa+	mofa+	PROPN
gs-4321	274	6	,	,	PUNCT
gs-4321	274	7	harmony	harmony	NOUN
gs-4321	274	8	,	,	PUNCT
gs-4321	274	9	and	and	CCONJ
gs-4321	274	10	seurat	seurat	PROPN
gs-4321	274	11	wnn	wnn	PROPN
gs-4321	274	12	integration	integration	NOUN
gs-4321	274	13	allow	allow	VERB
gs-4321	274	14	researchers	researcher	NOUN
gs-4321	274	15	to	to	PART
gs-4321	274	16	analyze	analyze	VERB
gs-4321	274	17	these	these	DET
gs-4321	274	18	multimodal	multimodal	NOUN
gs-4321	274	19	datasets	dataset	NOUN
gs-4321	274	20	collectively	collectively	ADV
gs-4321	274	21	,	,	PUNCT
gs-4321	274	22	generating	generate	VERB
gs-4321	274	23	unified	unified	ADJ
gs-4321	274	24	lowdimensional	lowdimensional	ADJ
gs-4321	274	25	embeddings	embedding	NOUN
gs-4321	274	26	that	that	PRON
gs-4321	274	27	capture	capture	VERB
gs-4321	274	28	shared	share	VERB
gs-4321	274	29	and	and	CCONJ
gs-4321	274	30	modality	modality	NOUN
gs-4321	274	31	-	-	PUNCT
gs-4321	274	32	specific	specific	ADJ
gs-4321	274	33	sources	source	NOUN
gs-4321	274	34	of	of	ADP
gs-4321	274	35	variation	variation	NOUN
gs-4321	274	36	(	(	PUNCT
gs-4321	274	37	argelaguet	argelaguet	NOUN
gs-4321	274	38	et	et	PROPN
gs-4321	274	39	al	al	PROPN
gs-4321	274	40	.	.	PROPN
gs-4321	274	41	,	,	PUNCT
gs-4321	274	42	2020	2020	NUM
gs-4321	274	43	;	;	PUNCT
gs-4321	274	44	hao	hao	PROPN
gs-4321	274	45	et	et	PROPN
gs-4321	274	46	al	al	PROPN
gs-4321	274	47	.	.	PROPN
gs-4321	274	48	,	,	PUNCT
gs-4321	274	49	2021	2021	NUM
gs-4321	274	50	)	)	PUNCT
gs-4321	274	51	.	.	PUNCT
gs-4321	275	1	these	these	DET
gs-4321	275	2	integrative	integrative	ADJ
gs-4321	275	3	strategies	strategy	NOUN
gs-4321	275	4	are	be	AUX
gs-4321	275	5	critical	critical	ADJ
gs-4321	275	6	for	for	ADP
gs-4321	275	7	dissecting	dissect	VERB
gs-4321	275	8	plasticity	plasticity	NOUN
gs-4321	275	9	because	because	SCONJ
gs-4321	275	10	no	no	DET
gs-4321	275	11	single	single	ADJ
gs-4321	275	12	modality	modality	NOUN
gs-4321	275	13	fully	fully	ADV
gs-4321	275	14	captures	capture	VERB
gs-4321	275	15	the	the	DET
gs-4321	275	16	complexity	complexity	NOUN
gs-4321	275	17	of	of	ADP
gs-4321	275	18	adaptive	adaptive	ADJ
gs-4321	275	19	transitions	transition	NOUN
gs-4321	275	20	.	.	PUNCT
gs-4321	276	1	transcriptional	transcriptional	ADJ
gs-4321	276	2	changes	change	NOUN
gs-4321	276	3	may	may	AUX
gs-4321	276	4	indicate	indicate	VERB
gs-4321	276	5	dynamic	dynamic	ADJ
gs-4321	276	6	state	state	NOUN
gs-4321	276	7	shifts	shift	NOUN
gs-4321	276	8	,	,	PUNCT
gs-4321	276	9	while	while	SCONJ
gs-4321	276	10	epigenomic	epigenomic	ADJ
gs-4321	276	11	and	and	CCONJ
gs-4321	276	12	proteomic	proteomic	ADJ
gs-4321	276	13	signatures	signature	NOUN
gs-4321	276	14	reflect	reflect	VERB
gs-4321	276	15	underlying	underlie	VERB
gs-4321	276	16	regulatory	regulatory	ADJ
gs-4321	276	17	and	and	CCONJ
gs-4321	276	18	functional	functional	ADJ
gs-4321	276	19	constraints	constraint	NOUN
gs-4321	276	20	.	.	PUNCT
gs-4321	277	1	by	by	ADP
gs-4321	277	2	aligning	align	VERB
gs-4321	277	3	these	these	DET
gs-4321	277	4	modalities	modality	NOUN
gs-4321	277	5	,	,	PUNCT
gs-4321	277	6	bioinformatic	bioinformatic	ADJ
gs-4321	277	7	pipelines	pipeline	NOUN
gs-4321	277	8	can	can	AUX
gs-4321	277	9	identify	identify	VERB
gs-4321	277	10	regulatory	regulatory	ADJ
gs-4321	277	11	nodes	node	NOUN
gs-4321	277	12	that	that	PRON
gs-4321	277	13	are	be	AUX
gs-4321	277	14	consistently	consistently	ADV
gs-4321	277	15	altered	alter	VERB
gs-4321	277	16	across	across	ADP
gs-4321	277	17	layers	layer	NOUN
gs-4321	277	18	,	,	PUNCT
gs-4321	277	19	providing	provide	VERB
gs-4321	277	20	deeper	deep	ADJ
gs-4321	277	21	mechanistic	mechanistic	ADJ
gs-4321	277	22	insight	insight	NOUN
gs-4321	277	23	into	into	ADP
gs-4321	277	24	how	how	SCONJ
gs-4321	277	25	adaptive	adaptive	ADJ
gs-4321	277	26	programs	program	NOUN
gs-4321	277	27	are	be	AUX
gs-4321	277	28	constructed	construct	VERB
gs-4321	277	29	.	.	PUNCT
gs-4321	278	1	proteogenomic	proteogenomic	ADJ
gs-4321	278	2	signatures	signature	NOUN
gs-4321	278	3	of	of	ADP
gs-4321	278	4	adaptive	adaptive	ADJ
gs-4321	278	5	states	state	NOUN
gs-4321	278	6	while	while	SCONJ
gs-4321	278	7	transcriptomic	transcriptomic	ADJ
gs-4321	278	8	and	and	CCONJ
gs-4321	278	9	epigenomic	epigenomic	ADJ
gs-4321	278	10	analyses	analysis	NOUN
gs-4321	278	11	dominate	dominate	VERB
gs-4321	278	12	single	single	ADJ
gs-4321	278	13	-	-	PUNCT
gs-4321	278	14	cell	cell	NOUN
gs-4321	278	15	research	research	NOUN
gs-4321	278	16	,	,	PUNCT
gs-4321	278	17	proteomics	proteomic	NOUN
gs-4321	278	18	also	also	ADV
gs-4321	278	19	plays	play	VERB
gs-4321	278	20	a	a	DET
gs-4321	278	21	crucial	crucial	ADJ
gs-4321	278	22	role	role	NOUN
gs-4321	278	23	in	in	ADP
gs-4321	278	24	defining	define	VERB
gs-4321	278	25	adaptive	adaptive	ADJ
gs-4321	278	26	behaviors	behavior	NOUN
gs-4321	278	27	.	.	PUNCT
gs-4321	279	1	recent	recent	ADJ
gs-4321	279	2	developments	development	NOUN
gs-4321	279	3	in	in	ADP
gs-4321	279	4	mass	mass	ADJ
gs-4321	279	5	cytometry	cytometry	NOUN
gs-4321	279	6	(	(	PUNCT
gs-4321	279	7	cytof	cytof	PROPN
gs-4321	279	8	)	)	PUNCT
gs-4321	279	9	,	,	PUNCT
gs-4321	279	10	imaging	image	VERB
gs-4321	279	11	mass	mass	NOUN
gs-4321	279	12	cytometry	cytometry	NOUN
gs-4321	279	13	,	,	PUNCT
gs-4321	279	14	and	and	CCONJ
gs-4321	279	15	emerging	emerge	VERB
gs-4321	279	16	single	single	ADJ
gs-4321	279	17	-	-	PUNCT
gs-4321	279	18	cell	cell	NOUN
gs-4321	279	19	proteomic	proteomic	NOUN
gs-4321	279	20	technologies	technology	NOUN
gs-4321	279	21	have	have	AUX
gs-4321	279	22	enabled	enable	VERB
gs-4321	279	23	quantification	quantification	NOUN
gs-4321	279	24	of	of	ADP
gs-4321	279	25	surface	surface	NOUN
gs-4321	279	26	markers	marker	NOUN
gs-4321	279	27	,	,	PUNCT
gs-4321	279	28	intracellular	intracellular	ADJ
gs-4321	279	29	proteins	protein	NOUN
gs-4321	279	30	,	,	PUNCT
gs-4321	279	31	and	and	CCONJ
gs-4321	279	32	signaling	signal	VERB
gs-4321	279	33	pathway	pathway	NOUN
gs-4321	279	34	activity	activity	NOUN
gs-4321	279	35	with	with	ADP
gs-4321	279	36	substantial	substantial	ADJ
gs-4321	279	37	depth	depth	NOUN
gs-4321	279	38	(	(	PUNCT
gs-4321	279	39	chevrier	chevrier	NOUN
gs-4321	279	40	et	et	PROPN
gs-4321	279	41	al	al	PROPN
gs-4321	279	42	.	.	PROPN
gs-4321	279	43	,	,	PUNCT
gs-4321	279	44	2018	2018	NUM
gs-4321	279	45	)	)	PUNCT
gs-4321	279	46	.	.	PUNCT
gs-4321	280	1	these	these	DET
gs-4321	280	2	platforms	platform	NOUN
gs-4321	280	3	provide	provide	VERB
gs-4321	280	4	direct	direct	ADJ
gs-4321	280	5	measurement	measurement	NOUN
gs-4321	280	6	of	of	ADP
gs-4321	280	7	functional	functional	ADJ
gs-4321	280	8	protein	protein	NOUN
gs-4321	280	9	networks	network	NOUN
gs-4321	280	10	that	that	PRON
gs-4321	280	11	may	may	AUX
gs-4321	280	12	not	not	PART
gs-4321	280	13	be	be	AUX
gs-4321	280	14	evident	evident	ADJ
gs-4321	280	15	from	from	ADP
gs-4321	280	16	rna	rna	NOUN
gs-4321	280	17	-	-	PUNCT
gs-4321	280	18	level	level	NOUN
gs-4321	280	19	data	datum	NOUN
gs-4321	280	20	alone	alone	ADV
gs-4321	280	21	.	.	PUNCT
gs-4321	281	1	for	for	ADP
gs-4321	281	2	example	example	NOUN
gs-4321	281	3	,	,	PUNCT
gs-4321	281	4	proteomic	proteomic	ADJ
gs-4321	281	5	analyses	analysis	NOUN
gs-4321	281	6	have	have	AUX
gs-4321	281	7	revealed	reveal	VERB
gs-4321	281	8	that	that	SCONJ
gs-4321	281	9	therapy	therapy	NOUN
gs-4321	281	10	-	-	PUNCT
gs-4321	281	11	resistant	resistant	ADJ
gs-4321	281	12	subpopulations	subpopulation	NOUN
gs-4321	281	13	frequently	frequently	ADV
gs-4321	281	14	exhibit	exhibit	VERB
gs-4321	281	15	activation	activation	NOUN
gs-4321	281	16	of	of	ADP
gs-4321	281	17	signaling	signal	VERB
gs-4321	281	18	pathways	pathway	NOUN
gs-4321	281	19	such	such	ADJ
gs-4321	281	20	as	as	ADP
gs-4321	281	21	pi3k	pi3k	PROPN
gs-4321	281	22	/	/	SYM
gs-4321	281	23	akt	akt	PROPN
gs-4321	281	24	,	,	PUNCT
gs-4321	281	25	mapk	mapk	NOUN
gs-4321	281	26	,	,	PUNCT
gs-4321	281	27	and	and	CCONJ
gs-4321	281	28	nfb	nfb	NOUN
gs-4321	281	29	,	,	PUNCT
gs-4321	281	30	even	even	ADV
gs-4321	281	31	when	when	SCONJ
gs-4321	281	32	transcriptomic	transcriptomic	ADJ
gs-4321	281	33	markers	marker	NOUN
gs-4321	281	34	of	of	ADP
gs-4321	281	35	these	these	DET
gs-4321	281	36	pathways	pathway	NOUN
gs-4321	281	37	remain	remain	VERB
gs-4321	281	38	unchanged	unchanged	ADJ
gs-4321	281	39	.	.	PUNCT
gs-4321	282	1	integrating	integrate	VERB
gs-4321	282	2	proteogenomic	proteogenomic	ADJ
gs-4321	282	3	data	datum	NOUN
gs-4321	282	4	with	with	ADP
gs-4321	282	5	single	single	ADJ
gs-4321	282	6	-	-	PUNCT
gs-4321	282	7	cell	cell	NOUN
gs-4321	282	8	transcriptomics	transcriptomic	NOUN
gs-4321	282	9	can	can	AUX
gs-4321	282	10	thus	thus	ADV
gs-4321	282	11	reveal	reveal	VERB
gs-4321	282	12	post	post	ADJ
gs-4321	282	13	-	-	ADJ
gs-4321	282	14	transcriptional	transcriptional	ADJ
gs-4321	282	15	regulatory	regulatory	ADJ
gs-4321	282	16	events	event	NOUN
gs-4321	282	17	,	,	PUNCT
gs-4321	282	18	protein	protein	NOUN
gs-4321	282	19	-	-	PUNCT
gs-4321	282	20	level	level	NOUN
gs-4321	282	21	feedback	feedback	NOUN
gs-4321	282	22	loops	loop	NOUN
gs-4321	282	23	,	,	PUNCT
gs-4321	282	24	and	and	CCONJ
gs-4321	282	25	phosphorylation	phosphorylation	NOUN
gs-4321	282	26	dynamics	dynamic	NOUN
gs-4321	282	27	essential	essential	ADJ
gs-4321	282	28	for	for	ADP
gs-4321	282	29	state	state	NOUN
gs-4321	282	30	transitions	transition	NOUN
gs-4321	282	31	.	.	PUNCT
gs-4321	283	1	computational	computational	ADJ
gs-4321	283	2	tools	tool	NOUN
gs-4321	283	3	that	that	PRON
gs-4321	283	4	fuse	fuse	VERB
gs-4321	283	5	proteomic	proteomic	NOUN
gs-4321	283	6	and	and	CCONJ
gs-4321	283	7	transcriptomic	transcriptomic	ADJ
gs-4321	283	8	signals	signal	NOUN
gs-4321	283	9	allow	allow	VERB
gs-4321	283	10	reconstruction	reconstruction	NOUN
gs-4321	283	11	of	of	ADP
gs-4321	283	12	integrated	integrate	VERB
gs-4321	283	13	regulatory	regulatory	ADJ
gs-4321	283	14	circuits	circuit	NOUN
gs-4321	283	15	that	that	PRON
gs-4321	283	16	govern	govern	VERB
gs-4321	283	17	plasticity	plasticity	NOUN
gs-4321	283	18	.	.	PUNCT
gs-4321	284	1	georgian	georgian	NOUN
gs-4321	284	2	scientists/	scientists/	NUM
gs-4321	284	3	.	.	PUNCT
gs-4321	285	1	7	7	NUM
gs-4321	285	2	n	n	DET
gs-4321	285	3	4	4	NUM
gs-4321	285	4	,	,	PUNCT
gs-4321	285	5	2025	2025	NUM
gs-4321	285	6	351	351	NUM
gs-4321	285	7	limitations	limitation	NOUN
gs-4321	285	8	and	and	CCONJ
gs-4321	285	9	computational	computational	ADJ
gs-4321	285	10	challenges	challenge	NOUN
gs-4321	285	11	despite	despite	SCONJ
gs-4321	285	12	remarkable	remarkable	ADJ
gs-4321	285	13	advances	advance	NOUN
gs-4321	285	14	,	,	PUNCT
gs-4321	285	15	multimodal	multimodal	ADJ
gs-4321	285	16	single	single	ADJ
gs-4321	285	17	-	-	PUNCT
gs-4321	285	18	cell	cell	NOUN
gs-4321	285	19	analysis	analysis	NOUN
gs-4321	285	20	presents	present	VERB
gs-4321	285	21	significant	significant	ADJ
gs-4321	285	22	computational	computational	ADJ
gs-4321	285	23	challenges	challenge	NOUN
gs-4321	285	24	.	.	PUNCT
gs-4321	286	1	differences	difference	NOUN
gs-4321	286	2	in	in	ADP
gs-4321	286	3	data	datum	NOUN
gs-4321	286	4	sparsity	sparsity	NOUN
gs-4321	286	5	,	,	PUNCT
gs-4321	286	6	noise	noise	NOUN
gs-4321	286	7	profiles	profile	NOUN
gs-4321	286	8	,	,	PUNCT
gs-4321	286	9	and	and	CCONJ
gs-4321	286	10	feature	feature	NOUN
gs-4321	286	11	sets	set	NOUN
gs-4321	286	12	across	across	ADP
gs-4321	286	13	modalities	modality	NOUN
gs-4321	286	14	complicate	complicate	VERB
gs-4321	286	15	integration	integration	NOUN
gs-4321	286	16	.	.	PUNCT
gs-4321	287	1	moreover	moreover	ADV
gs-4321	287	2	,	,	PUNCT
gs-4321	287	3	scaling	scale	VERB
gs-4321	287	4	analyses	analysis	NOUN
gs-4321	287	5	to	to	ADP
gs-4321	287	6	millions	million	NOUN
gs-4321	287	7	of	of	ADP
gs-4321	287	8	cells	cell	NOUN
gs-4321	287	9	now	now	ADV
gs-4321	287	10	routinely	routinely	ADV
gs-4321	287	11	generated	generate	VERB
gs-4321	287	12	by	by	ADP
gs-4321	287	13	modern	modern	ADJ
gs-4321	287	14	workflows	workflow	NOUN
gs-4321	287	15	requires	require	VERB
gs-4321	287	16	high	high	ADJ
gs-4321	287	17	-	-	PUNCT
gs-4321	287	18	performance	performance	NOUN
gs-4321	287	19	algorithms	algorithm	NOUN
gs-4321	287	20	capable	capable	ADJ
gs-4321	287	21	of	of	ADP
gs-4321	287	22	handling	handle	VERB
gs-4321	287	23	complex	complex	ADJ
gs-4321	287	24	,	,	PUNCT
gs-4321	287	25	high	high	ADJ
gs-4321	287	26	-	-	PUNCT
gs-4321	287	27	dimensional	dimensional	ADJ
gs-4321	287	28	data	datum	NOUN
gs-4321	287	29	structures	structure	NOUN
gs-4321	287	30	.	.	PUNCT
gs-4321	288	1	batch	batch	NOUN
gs-4321	288	2	effects	effect	NOUN
gs-4321	288	3	,	,	PUNCT
gs-4321	288	4	donor	donor	NOUN
gs-4321	288	5	variability	variability	NOUN
gs-4321	288	6	,	,	PUNCT
gs-4321	288	7	and	and	CCONJ
gs-4321	288	8	technical	technical	ADJ
gs-4321	288	9	inconsistencies	inconsistency	NOUN
gs-4321	288	10	also	also	ADV
gs-4321	288	11	demand	demand	VERB
gs-4321	288	12	robust	robust	ADJ
gs-4321	288	13	normalization	normalization	NOUN
gs-4321	288	14	and	and	CCONJ
gs-4321	288	15	integration	integration	NOUN
gs-4321	288	16	strategies	strategy	NOUN
gs-4321	288	17	.	.	PUNCT
gs-4321	289	1	nevertheless	nevertheless	ADV
gs-4321	289	2	,	,	PUNCT
gs-4321	289	3	ongoing	ongoing	ADJ
gs-4321	289	4	development	development	NOUN
gs-4321	289	5	of	of	ADP
gs-4321	289	6	machine	machine	NOUN
gs-4321	289	7	-	-	PUNCT
gs-4321	289	8	learning	learning	NOUN
gs-4321	289	9	–	–	PUNCT
gs-4321	289	10	based	base	VERB
gs-4321	289	11	integration	integration	NOUN
gs-4321	289	12	tools	tool	NOUN
gs-4321	289	13	,	,	PUNCT
gs-4321	289	14	graphbased	graphbased	ADJ
gs-4321	289	15	data	data	NOUN
gs-4321	289	16	structures	structure	NOUN
gs-4321	289	17	,	,	PUNCT
gs-4321	289	18	and	and	CCONJ
gs-4321	289	19	probabilistic	probabilistic	ADJ
gs-4321	289	20	modeling	modeling	NOUN
gs-4321	289	21	frameworks	framework	NOUN
gs-4321	289	22	continues	continue	VERB
gs-4321	289	23	to	to	PART
gs-4321	289	24	expand	expand	VERB
gs-4321	289	25	the	the	DET
gs-4321	289	26	analytical	analytical	ADJ
gs-4321	289	27	capacity	capacity	NOUN
gs-4321	289	28	of	of	ADP
gs-4321	289	29	single	single	ADJ
gs-4321	289	30	-	-	PUNCT
gs-4321	289	31	cell	cell	NOUN
gs-4321	289	32	bioinformatics	bioinformatics	NOUN
gs-4321	289	33	.	.	PUNCT
gs-4321	290	1	these	these	DET
gs-4321	290	2	innovations	innovation	NOUN
gs-4321	290	3	provide	provide	VERB
gs-4321	290	4	increasingly	increasingly	ADV
gs-4321	290	5	powerful	powerful	ADJ
gs-4321	290	6	means	mean	NOUN
gs-4321	290	7	to	to	PART
gs-4321	290	8	elucidate	elucidate	VERB
gs-4321	290	9	the	the	DET
gs-4321	290	10	molecular	molecular	ADJ
gs-4321	290	11	and	and	CCONJ
gs-4321	290	12	ecological	ecological	ADJ
gs-4321	290	13	determinants	determinant	NOUN
gs-4321	290	14	of	of	ADP
gs-4321	290	15	phenotypic	phenotypic	ADJ
gs-4321	290	16	flexibility	flexibility	NOUN
gs-4321	290	17	within	within	ADP
gs-4321	290	18	tumors	tumor	NOUN
gs-4321	290	19	.	.	PUNCT
gs-4321	291	1	tumor	tumor	NOUN
gs-4321	291	2	ecosystem	ecosystem	NOUN
gs-4321	291	3	complexity	complexity	NOUN
gs-4321	291	4	and	and	CCONJ
gs-4321	291	5	emergent	emergent	ADJ
gs-4321	291	6	behavior	behavior	NOUN
gs-4321	291	7	tumors	tumor	NOUN
gs-4321	291	8	are	be	AUX
gs-4321	291	9	best	well	ADV
gs-4321	291	10	understood	understand	VERB
gs-4321	291	11	as	as	ADP
gs-4321	291	12	ecosystems	ecosystem	NOUN
gs-4321	291	13	composed	compose	VERB
gs-4321	291	14	of	of	ADP
gs-4321	291	15	diverse	diverse	ADJ
gs-4321	291	16	cell	cell	NOUN
gs-4321	291	17	populations	population	NOUN
gs-4321	291	18	that	that	PRON
gs-4321	291	19	engage	engage	VERB
gs-4321	291	20	in	in	ADP
gs-4321	291	21	complex	complex	ADJ
gs-4321	291	22	interactions	interaction	NOUN
gs-4321	291	23	,	,	PUNCT
gs-4321	291	24	collectively	collectively	ADV
gs-4321	291	25	shaping	shape	VERB
gs-4321	291	26	emergent	emergent	ADJ
gs-4321	291	27	behaviors	behavior	NOUN
gs-4321	291	28	such	such	ADJ
gs-4321	291	29	as	as	ADP
gs-4321	291	30	adaptation	adaptation	NOUN
gs-4321	291	31	,	,	PUNCT
gs-4321	291	32	resistance	resistance	NOUN
gs-4321	291	33	,	,	PUNCT
gs-4321	291	34	and	and	CCONJ
gs-4321	291	35	metastatic	metastatic	ADJ
gs-4321	291	36	progression	progression	NOUN
gs-4321	291	37	.	.	PUNCT
gs-4321	292	1	single	single	ADJ
gs-4321	292	2	-	-	PUNCT
gs-4321	292	3	cell	cell	NOUN
gs-4321	292	4	bioinformatic	bioinformatic	ADJ
gs-4321	292	5	analyses	analysis	NOUN
gs-4321	292	6	provide	provide	VERB
gs-4321	292	7	a	a	DET
gs-4321	292	8	lens	lens	NOUN
gs-4321	292	9	through	through	ADP
gs-4321	292	10	which	which	PRON
gs-4321	292	11	these	these	DET
gs-4321	292	12	interactions	interaction	NOUN
gs-4321	292	13	can	can	AUX
gs-4321	292	14	be	be	AUX
gs-4321	292	15	resolved	resolve	VERB
gs-4321	292	16	,	,	PUNCT
gs-4321	292	17	revealing	reveal	VERB
gs-4321	292	18	previously	previously	ADV
gs-4321	292	19	unrecognized	unrecognize	VERB
gs-4321	292	20	substructures	substructure	NOUN
gs-4321	292	21	within	within	ADP
gs-4321	292	22	malignant	malignant	ADJ
gs-4321	292	23	and	and	CCONJ
gs-4321	292	24	non	non	ADJ
gs-4321	292	25	-	-	ADJ
gs-4321	292	26	malignant	malignant	ADJ
gs-4321	292	27	compartments	compartment	NOUN
gs-4321	292	28	.	.	PUNCT
gs-4321	293	1	for	for	ADP
gs-4321	293	2	example	example	NOUN
gs-4321	293	3	,	,	PUNCT
gs-4321	293	4	studies	study	NOUN
gs-4321	293	5	of	of	ADP
gs-4321	293	6	lung	lung	NOUN
gs-4321	293	7	cancer	cancer	NOUN
gs-4321	293	8	,	,	PUNCT
gs-4321	293	9	colorectal	colorectal	ADJ
gs-4321	293	10	carcinoma	carcinoma	NOUN
gs-4321	293	11	,	,	PUNCT
gs-4321	293	12	and	and	CCONJ
gs-4321	293	13	glioblastoma	glioblastoma	NOUN
gs-4321	293	14	have	have	AUX
gs-4321	293	15	shown	show	VERB
gs-4321	293	16	that	that	SCONJ
gs-4321	293	17	tumor	tumor	NOUN
gs-4321	293	18	cells	cell	NOUN
gs-4321	293	19	form	form	VERB
gs-4321	293	20	functionally	functionally	ADV
gs-4321	293	21	distinct	distinct	ADJ
gs-4321	293	22	neighborhoods	neighborhood	NOUN
gs-4321	293	23	,	,	PUNCT
gs-4321	293	24	each	each	PRON
gs-4321	293	25	characterized	characterize	VERB
gs-4321	293	26	by	by	ADP
gs-4321	293	27	unique	unique	ADJ
gs-4321	293	28	transcriptional	transcriptional	ADJ
gs-4321	293	29	states	state	NOUN
gs-4321	293	30	,	,	PUNCT
gs-4321	293	31	microenvironmental	microenvironmental	ADJ
gs-4321	293	32	signals	signal	NOUN
gs-4321	293	33	,	,	PUNCT
gs-4321	293	34	and	and	CCONJ
gs-4321	293	35	regulatory	regulatory	ADJ
gs-4321	293	36	determinants	determinant	NOUN
gs-4321	293	37	(	(	PUNCT
gs-4321	293	38	kim	kim	PROPN
gs-4321	293	39	et	et	PROPN
gs-4321	293	40	al	al	PROPN
gs-4321	293	41	.	.	PROPN
gs-4321	293	42	,	,	PUNCT
gs-4321	293	43	2020	2020	NUM
gs-4321	293	44	;	;	PUNCT
gs-4321	293	45	lee	lee	PROPN
gs-4321	293	46	et	et	PROPN
gs-4321	293	47	al	al	PROPN
gs-4321	293	48	.	.	PROPN
gs-4321	293	49	,	,	PUNCT
gs-4321	293	50	2020	2020	NUM
gs-4321	293	51	)	)	PUNCT
gs-4321	293	52	.	.	PUNCT
gs-4321	294	1	these	these	DET
gs-4321	294	2	localized	localize	VERB
gs-4321	294	3	microecosystems	microecosystem	NOUN
gs-4321	294	4	contribute	contribute	VERB
gs-4321	294	5	to	to	ADP
gs-4321	294	6	phenotypic	phenotypic	ADJ
gs-4321	294	7	diversification	diversification	NOUN
gs-4321	294	8	by	by	ADP
gs-4321	294	9	generating	generate	VERB
gs-4321	294	10	region	region	NOUN
gs-4321	294	11	-	-	PUNCT
gs-4321	294	12	specific	specific	ADJ
gs-4321	294	13	selective	selective	ADJ
gs-4321	294	14	pressures	pressure	NOUN
gs-4321	294	15	that	that	PRON
gs-4321	294	16	favor	favor	VERB
gs-4321	294	17	particular	particular	ADJ
gs-4321	294	18	adaptive	adaptive	ADJ
gs-4321	294	19	states	state	NOUN
gs-4321	294	20	.	.	PUNCT
gs-4321	295	1	within	within	ADP
gs-4321	295	2	these	these	DET
gs-4321	295	3	ecosystems	ecosystem	NOUN
gs-4321	295	4	,	,	PUNCT
gs-4321	295	5	plasticity	plasticity	NOUN
gs-4321	295	6	emerges	emerge	VERB
gs-4321	295	7	as	as	ADP
gs-4321	295	8	a	a	DET
gs-4321	295	9	collective	collective	ADJ
gs-4321	295	10	product	product	NOUN
gs-4321	295	11	of	of	ADP
gs-4321	295	12	both	both	DET
gs-4321	295	13	intrinsic	intrinsic	ADJ
gs-4321	295	14	regulatory	regulatory	ADJ
gs-4321	295	15	networks	network	NOUN
gs-4321	295	16	and	and	CCONJ
gs-4321	295	17	extrinsic	extrinsic	ADJ
gs-4321	295	18	cues	cue	NOUN
gs-4321	295	19	generated	generate	VERB
gs-4321	295	20	by	by	ADP
gs-4321	295	21	surrounding	surround	VERB
gs-4321	295	22	cells	cell	NOUN
gs-4321	295	23	.	.	PUNCT
gs-4321	296	1	as	as	SCONJ
gs-4321	296	2	spatially	spatially	ADV
gs-4321	296	3	resolved	resolve	VERB
gs-4321	296	4	and	and	CCONJ
gs-4321	296	5	multiomic	multiomic	ADJ
gs-4321	296	6	single	single	ADJ
gs-4321	296	7	-	-	PUNCT
gs-4321	296	8	cell	cell	NOUN
gs-4321	296	9	datasets	dataset	NOUN
gs-4321	296	10	grow	grow	VERB
gs-4321	296	11	,	,	PUNCT
gs-4321	296	12	bioinformatic	bioinformatic	ADJ
gs-4321	296	13	approaches	approach	NOUN
gs-4321	296	14	have	have	AUX
gs-4321	296	15	begun	begin	VERB
gs-4321	296	16	to	to	PART
gs-4321	296	17	identify	identify	VERB
gs-4321	296	18	recurrent	recurrent	ADJ
gs-4321	296	19	ecological	ecological	ADJ
gs-4321	296	20	motifs	motif	NOUN
gs-4321	296	21	—	—	PUNCT
gs-4321	296	22	such	such	ADJ
gs-4321	296	23	as	as	ADP
gs-4321	296	24	immune	immune	NOUN
gs-4321	296	25	-	-	PUNCT
gs-4321	296	26	excluded	exclude	VERB
gs-4321	296	27	zones	zone	NOUN
gs-4321	296	28	,	,	PUNCT
gs-4321	296	29	hypoxic	hypoxic	ADJ
gs-4321	296	30	niches	niche	NOUN
gs-4321	296	31	,	,	PUNCT
gs-4321	296	32	inflammatory	inflammatory	ADJ
gs-4321	296	33	hubs	hub	NOUN
gs-4321	296	34	,	,	PUNCT
gs-4321	296	35	and	and	CCONJ
gs-4321	296	36	fibroblast	fibroblast	ADJ
gs-4321	296	37	-	-	PUNCT
gs-4321	296	38	enriched	enrich	VERB
gs-4321	296	39	stromal	stromal	ADJ
gs-4321	296	40	corridors	corridor	NOUN
gs-4321	296	41	—	—	PUNCT
gs-4321	296	42	that	that	PRON
gs-4321	296	43	exert	exert	VERB
gs-4321	296	44	strong	strong	ADJ
gs-4321	296	45	shaping	shaping	NOUN
gs-4321	296	46	forces	force	NOUN
gs-4321	296	47	on	on	ADP
gs-4321	296	48	malignant	malignant	ADJ
gs-4321	296	49	cell	cell	NOUN
gs-4321	296	50	behavior	behavior	NOUN
gs-4321	296	51	.	.	PUNCT
gs-4321	297	1	understanding	understand	VERB
gs-4321	297	2	how	how	SCONJ
gs-4321	297	3	these	these	DET
gs-4321	297	4	motifs	motif	NOUN
gs-4321	297	5	influence	influence	NOUN
gs-4321	297	6	state	state	NOUN
gs-4321	297	7	interconversion	interconversion	NOUN
gs-4321	297	8	is	be	AUX
gs-4321	297	9	essential	essential	ADJ
gs-4321	297	10	for	for	ADP
gs-4321	297	11	predicting	predict	VERB
gs-4321	297	12	therapeutic	therapeutic	ADJ
gs-4321	297	13	response	response	NOUN
gs-4321	297	14	and	and	CCONJ
gs-4321	297	15	resistance	resistance	NOUN
gs-4321	297	16	trajectories	trajectory	NOUN
gs-4321	297	17	.	.	PUNCT
gs-4321	298	1	microenvironmental	microenvironmental	ADJ
gs-4321	298	2	stress	stress	NOUN
gs-4321	298	3	and	and	CCONJ
gs-4321	298	4	adaptive	adaptive	ADJ
gs-4321	298	5	rewiring	rewiring	ADJ
gs-4321	298	6	environmental	environmental	ADJ
gs-4321	298	7	stressors	stressor	NOUN
gs-4321	298	8	,	,	PUNCT
gs-4321	298	9	including	include	VERB
gs-4321	298	10	nutrient	nutrient	NOUN
gs-4321	298	11	deprivation	deprivation	NOUN
gs-4321	298	12	,	,	PUNCT
gs-4321	298	13	mechanical	mechanical	ADJ
gs-4321	298	14	pressure	pressure	NOUN
gs-4321	298	15	,	,	PUNCT
gs-4321	298	16	oxidative	oxidative	ADJ
gs-4321	298	17	stress	stress	NOUN
gs-4321	298	18	,	,	PUNCT
gs-4321	298	19	and	and	CCONJ
gs-4321	298	20	exposure	exposure	NOUN
gs-4321	298	21	to	to	ADP
gs-4321	298	22	therapy	therapy	NOUN
gs-4321	298	23	,	,	PUNCT
gs-4321	298	24	play	play	VERB
gs-4321	298	25	a	a	DET
gs-4321	298	26	major	major	ADJ
gs-4321	298	27	role	role	NOUN
gs-4321	298	28	in	in	ADP
gs-4321	298	29	triggering	trigger	VERB
gs-4321	298	30	phenotypic	phenotypic	ADJ
gs-4321	298	31	transitions	transition	NOUN
gs-4321	298	32	.	.	PUNCT
gs-4321	299	1	single	single	ADJ
gs-4321	299	2	-	-	PUNCT
gs-4321	299	3	cell	cell	NOUN
gs-4321	299	4	transcriptomic	transcriptomic	ADJ
gs-4321	299	5	data	datum	NOUN
gs-4321	299	6	reveal	reveal	VERB
gs-4321	299	7	that	that	SCONJ
gs-4321	299	8	cells	cell	NOUN
gs-4321	299	9	under	under	ADP
gs-4321	299	10	stress	stress	NOUN
gs-4321	299	11	often	often	ADV
gs-4321	299	12	exhibit	exhibit	VERB
gs-4321	299	13	upregulation	upregulation	NOUN
gs-4321	299	14	of	of	ADP
gs-4321	299	15	adaptive	adaptive	ADJ
gs-4321	299	16	pathways	pathway	NOUN
gs-4321	299	17	such	such	ADJ
gs-4321	299	18	as	as	ADP
gs-4321	299	19	autophagy	autophagy	ADJ
gs-4321	299	20	,	,	PUNCT
gs-4321	299	21	unfolded	unfold	VERB
gs-4321	299	22	protein	protein	NOUN
gs-4321	299	23	response	response	NOUN
gs-4321	299	24	,	,	PUNCT
gs-4321	299	25	antioxidant	antioxidant	ADJ
gs-4321	299	26	defenses	defense	NOUN
gs-4321	299	27	,	,	PUNCT
gs-4321	299	28	and	and	CCONJ
gs-4321	299	29	dna	dna	PROPN
gs-4321	299	30	damage	damage	NOUN
gs-4321	299	31	repair	repair	NOUN
gs-4321	299	32	—	—	PUNCT
gs-4321	299	33	changes	change	NOUN
gs-4321	299	34	that	that	PRON
gs-4321	299	35	enable	enable	VERB
gs-4321	299	36	survival	survival	NOUN
gs-4321	299	37	during	during	ADP
gs-4321	299	38	periods	period	NOUN
gs-4321	299	39	of	of	ADP
gs-4321	299	40	intense	intense	ADJ
gs-4321	299	41	selective	selective	ADJ
gs-4321	299	42	pressure	pressure	NOUN
gs-4321	299	43	(	(	PUNCT
gs-4321	299	44	falletta	falletta	ADJ
gs-4321	299	45	et	et	PROPN
gs-4321	299	46	al	al	PROPN
gs-4321	299	47	.	.	PROPN
gs-4321	299	48	,	,	PUNCT
gs-4321	299	49	2017	2017	NUM
gs-4321	299	50	;	;	PUNCT
gs-4321	299	51	o’donnell	o’donnell	PROPN
gs-4321	299	52	et	et	NOUN
gs-4321	299	53	al	al	PROPN
gs-4321	299	54	.	.	PROPN
gs-4321	299	55	,	,	PUNCT
gs-4321	299	56	2021	2021	NUM
gs-4321	299	57	)	)	PUNCT
gs-4321	299	58	.	.	PUNCT
gs-4321	300	1	these	these	DET
gs-4321	300	2	stress	stress	NOUN
gs-4321	300	3	-	-	PUNCT
gs-4321	300	4	induced	induce	VERB
gs-4321	300	5	programs	program	NOUN
gs-4321	300	6	georgian	georgian	NOUN
gs-4321	300	7	scientists/	scientists/	NUM
gs-4321	300	8	.	.	PUNCT
gs-4321	301	1	7	7	NUM
gs-4321	301	2	n	n	DET
gs-4321	301	3	4	4	NUM
gs-4321	301	4	,	,	PUNCT
gs-4321	301	5	2025	2025	NUM
gs-4321	301	6	352	352	NUM
gs-4321	301	7	frequently	frequently	ADV
gs-4321	301	8	overlap	overlap	VERB
gs-4321	301	9	with	with	ADP
gs-4321	301	10	stem	stem	NOUN
gs-4321	301	11	-	-	PUNCT
gs-4321	301	12	associated	associate	VERB
gs-4321	301	13	regulatory	regulatory	ADJ
gs-4321	301	14	networks	network	NOUN
gs-4321	301	15	,	,	PUNCT
gs-4321	301	16	suggesting	suggest	VERB
gs-4321	301	17	that	that	SCONJ
gs-4321	301	18	plasticity	plasticity	NOUN
gs-4321	301	19	may	may	AUX
gs-4321	301	20	represent	represent	VERB
gs-4321	301	21	a	a	DET
gs-4321	301	22	generalized	generalized	ADJ
gs-4321	301	23	survival	survival	NOUN
gs-4321	301	24	strategy	strategy	NOUN
gs-4321	301	25	adopted	adopt	VERB
gs-4321	301	26	across	across	ADP
gs-4321	301	27	tumor	tumor	NOUN
gs-4321	301	28	types	type	NOUN
gs-4321	301	29	.	.	PUNCT
gs-4321	302	1	epigenomic	epigenomic	ADJ
gs-4321	302	2	analyses	analysis	NOUN
gs-4321	302	3	further	far	ADV
gs-4321	302	4	demonstrate	demonstrate	VERB
gs-4321	302	5	that	that	SCONJ
gs-4321	302	6	stress	stress	NOUN
gs-4321	302	7	can	can	AUX
gs-4321	302	8	induce	induce	VERB
gs-4321	302	9	rapid	rapid	ADJ
gs-4321	302	10	chromatin	chromatin	NOUN
gs-4321	302	11	remodeling	remodeling	NOUN
gs-4321	302	12	,	,	PUNCT
gs-4321	302	13	opening	opening	NOUN
gs-4321	302	14	regions	region	NOUN
gs-4321	302	15	enriched	enrich	VERB
gs-4321	302	16	for	for	ADP
gs-4321	302	17	motifs	motif	NOUN
gs-4321	302	18	of	of	ADP
gs-4321	302	19	stress	stress	NOUN
gs-4321	302	20	-	-	PUNCT
gs-4321	302	21	responsive	responsive	ADJ
gs-4321	302	22	transcription	transcription	NOUN
gs-4321	302	23	factors	factor	NOUN
gs-4321	302	24	such	such	ADJ
gs-4321	302	25	as	as	ADP
gs-4321	302	26	atf4	atf4	NOUN
gs-4321	302	27	,	,	PUNCT
gs-4321	302	28	stat3	stat3	NOUN
gs-4321	302	29	,	,	PUNCT
gs-4321	302	30	and	and	CCONJ
gs-4321	302	31	ap-1	ap-1	ADV
gs-4321	302	32	.	.	PUNCT
gs-4321	303	1	this	this	DET
gs-4321	303	2	remodeling	remodeling	NOUN
gs-4321	303	3	creates	create	VERB
gs-4321	303	4	permissive	permissive	ADJ
gs-4321	303	5	regulatory	regulatory	ADJ
gs-4321	303	6	landscapes	landscape	NOUN
gs-4321	303	7	that	that	PRON
gs-4321	303	8	facilitate	facilitate	VERB
gs-4321	303	9	transitions	transition	NOUN
gs-4321	303	10	into	into	ADP
gs-4321	303	11	adaptive	adaptive	ADJ
gs-4321	303	12	states	state	NOUN
gs-4321	303	13	.	.	PUNCT
gs-4321	304	1	computational	computational	ADJ
gs-4321	304	2	methods	method	NOUN
gs-4321	304	3	that	that	PRON
gs-4321	304	4	integrate	integrate	VERB
gs-4321	304	5	stresssignature	stresssignature	ADJ
gs-4321	304	6	scoring	scoring	NOUN
gs-4321	304	7	,	,	PUNCT
gs-4321	304	8	enhancer	enhancer	NOUN
gs-4321	304	9	profiling	profiling	NOUN
gs-4321	304	10	,	,	PUNCT
gs-4321	304	11	and	and	CCONJ
gs-4321	304	12	pathway	pathway	NOUN
gs-4321	304	13	activity	activity	NOUN
gs-4321	304	14	inference	inference	NOUN
gs-4321	304	15	allow	allow	VERB
gs-4321	304	16	systematic	systematic	ADJ
gs-4321	304	17	mapping	mapping	NOUN
gs-4321	304	18	of	of	ADP
gs-4321	304	19	how	how	SCONJ
gs-4321	304	20	stress	stress	NOUN
gs-4321	304	21	reshapes	reshape	VERB
gs-4321	304	22	regulatory	regulatory	ADJ
gs-4321	304	23	networks	network	NOUN
gs-4321	304	24	at	at	ADP
gs-4321	304	25	single	single	ADJ
gs-4321	304	26	-	-	PUNCT
gs-4321	304	27	cell	cell	NOUN
gs-4321	304	28	resolution	resolution	NOUN
gs-4321	304	29	.	.	PUNCT
gs-4321	305	1	therapeutic	therapeutic	ADJ
gs-4321	305	2	pressure	pressure	NOUN
gs-4321	305	3	as	as	ADP
gs-4321	305	4	a	a	DET
gs-4321	305	5	catalyst	catalyst	NOUN
gs-4321	305	6	for	for	ADP
gs-4321	305	7	state	state	NOUN
gs-4321	305	8	transitions	transition	NOUN
gs-4321	305	9	therapy	therapy	NOUN
gs-4321	305	10	-	-	PUNCT
gs-4321	305	11	induced	induce	VERB
gs-4321	305	12	plasticity	plasticity	NOUN
gs-4321	305	13	has	have	AUX
gs-4321	305	14	emerged	emerge	VERB
gs-4321	305	15	as	as	ADP
gs-4321	305	16	a	a	DET
gs-4321	305	17	major	major	ADJ
gs-4321	305	18	obstacle	obstacle	NOUN
gs-4321	305	19	to	to	ADP
gs-4321	305	20	durable	durable	ADJ
gs-4321	305	21	clinical	clinical	ADJ
gs-4321	305	22	response	response	NOUN
gs-4321	305	23	across	across	ADP
gs-4321	305	24	cancers	cancer	NOUN
gs-4321	305	25	.	.	PUNCT
gs-4321	306	1	even	even	ADV
gs-4321	306	2	when	when	SCONJ
gs-4321	306	3	treatments	treatment	NOUN
gs-4321	306	4	effectively	effectively	ADV
gs-4321	306	5	eliminate	eliminate	VERB
gs-4321	306	6	bulk	bulk	ADJ
gs-4321	306	7	tumor	tumor	NOUN
gs-4321	306	8	populations	population	NOUN
gs-4321	306	9	,	,	PUNCT
gs-4321	306	10	small	small	ADJ
gs-4321	306	11	subpopulations	subpopulation	NOUN
gs-4321	306	12	with	with	ADP
gs-4321	306	13	enhanced	enhanced	ADJ
gs-4321	306	14	adaptability	adaptability	NOUN
gs-4321	306	15	survive	survive	NOUN
gs-4321	306	16	and	and	CCONJ
gs-4321	306	17	repopulate	repopulate	VERB
gs-4321	306	18	the	the	DET
gs-4321	306	19	tumor	tumor	NOUN
gs-4321	306	20	.	.	PUNCT
gs-4321	307	1	single	single	ADJ
gs-4321	307	2	-	-	PUNCT
gs-4321	307	3	cell	cell	NOUN
gs-4321	307	4	analyses	analysis	NOUN
gs-4321	307	5	in	in	ADP
gs-4321	307	6	melanoma	melanoma	NOUN
gs-4321	307	7	,	,	PUNCT
gs-4321	307	8	breast	breast	NOUN
gs-4321	307	9	cancer	cancer	NOUN
gs-4321	307	10	,	,	PUNCT
gs-4321	307	11	and	and	CCONJ
gs-4321	307	12	lung	lung	NOUN
gs-4321	307	13	cancer	cancer	NOUN
gs-4321	307	14	have	have	AUX
gs-4321	307	15	shown	show	VERB
gs-4321	307	16	that	that	SCONJ
gs-4321	307	17	therapy	therapy	NOUN
gs-4321	307	18	-	-	PUNCT
gs-4321	307	19	resistant	resistant	ADJ
gs-4321	307	20	cells	cell	NOUN
gs-4321	307	21	often	often	ADV
gs-4321	307	22	occupy	occupy	VERB
gs-4321	307	23	transient	transient	ADJ
gs-4321	307	24	intermediate	intermediate	ADJ
gs-4321	307	25	states	state	NOUN
gs-4321	307	26	prior	prior	ADV
gs-4321	307	27	to	to	ADP
gs-4321	307	28	acquiring	acquire	VERB
gs-4321	307	29	full	full	ADJ
gs-4321	307	30	resistance	resistance	NOUN
gs-4321	307	31	phenotypes	phenotype	NOUN
gs-4321	307	32	(	(	PUNCT
gs-4321	307	33	sharma	sharma	PROPN
gs-4321	307	34	et	et	PROPN
gs-4321	307	35	al	al	PROPN
gs-4321	307	36	.	.	PROPN
gs-4321	307	37	,	,	PUNCT
gs-4321	307	38	2010	2010	NUM
gs-4321	307	39	;	;	PUNCT
gs-4321	307	40	oren	oren	NOUN
gs-4321	307	41	et	et	PROPN
gs-4321	307	42	al	al	PROPN
gs-4321	307	43	.	.	PROPN
gs-4321	307	44	,	,	PUNCT
gs-4321	307	45	2021	2021	NUM
gs-4321	307	46	)	)	PUNCT
gs-4321	307	47	.	.	PUNCT
gs-4321	308	1	these	these	DET
gs-4321	308	2	intermediate	intermediate	ADJ
gs-4321	308	3	states	state	NOUN
gs-4321	308	4	are	be	AUX
gs-4321	308	5	characterized	characterize	VERB
gs-4321	308	6	by	by	ADP
gs-4321	308	7	partial	partial	ADJ
gs-4321	308	8	activation	activation	NOUN
gs-4321	308	9	of	of	ADP
gs-4321	308	10	stress	stress	NOUN
gs-4321	308	11	pathways	pathway	NOUN
gs-4321	308	12	,	,	PUNCT
gs-4321	308	13	alterations	alteration	NOUN
gs-4321	308	14	in	in	ADP
gs-4321	308	15	cell	cell	NOUN
gs-4321	308	16	-	-	PUNCT
gs-4321	308	17	cycle	cycle	NOUN
gs-4321	308	18	dynamics	dynamic	NOUN
gs-4321	308	19	,	,	PUNCT
gs-4321	308	20	and	and	CCONJ
gs-4321	308	21	modulation	modulation	NOUN
gs-4321	308	22	of	of	ADP
gs-4321	308	23	lineage	lineage	NOUN
gs-4321	308	24	-	-	PUNCT
gs-4321	308	25	specifying	specify	VERB
gs-4321	308	26	transcription	transcription	NOUN
gs-4321	308	27	factors	factor	NOUN
gs-4321	308	28	.	.	PUNCT
gs-4321	309	1	computational	computational	ADJ
gs-4321	309	2	trajectory	trajectory	NOUN
gs-4321	309	3	inference	inference	NOUN
gs-4321	309	4	combined	combine	VERB
gs-4321	309	5	with	with	ADP
gs-4321	309	6	velocity	velocity	NOUN
gs-4321	309	7	-	-	PUNCT
gs-4321	309	8	based	base	VERB
gs-4321	309	9	modeling	modeling	NOUN
gs-4321	309	10	enables	enable	VERB
gs-4321	309	11	reconstruction	reconstruction	NOUN
gs-4321	309	12	of	of	ADP
gs-4321	309	13	these	these	DET
gs-4321	309	14	adaptive	adaptive	ADJ
gs-4321	309	15	paths	path	NOUN
gs-4321	309	16	,	,	PUNCT
gs-4321	309	17	revealing	reveal	VERB
gs-4321	309	18	early	early	ADJ
gs-4321	309	19	transcriptional	transcriptional	ADJ
gs-4321	309	20	events	event	NOUN
gs-4321	309	21	that	that	PRON
gs-4321	309	22	predict	predict	VERB
gs-4321	309	23	the	the	DET
gs-4321	309	24	emergence	emergence	NOUN
gs-4321	309	25	of	of	ADP
gs-4321	309	26	resistant	resistant	ADJ
gs-4321	309	27	states	state	NOUN
gs-4321	309	28	.	.	PUNCT
gs-4321	310	1	identification	identification	NOUN
gs-4321	310	2	of	of	ADP
gs-4321	310	3	these	these	DET
gs-4321	310	4	early	early	ADJ
gs-4321	310	5	markers	marker	NOUN
gs-4321	310	6	is	be	AUX
gs-4321	310	7	crucial	crucial	ADJ
gs-4321	310	8	for	for	ADP
gs-4321	310	9	developing	develop	VERB
gs-4321	310	10	strategies	strategy	NOUN
gs-4321	310	11	that	that	PRON
gs-4321	310	12	preemptively	preemptively	ADV
gs-4321	310	13	target	target	VERB
gs-4321	310	14	adaptive	adaptive	ADJ
gs-4321	310	15	transitions	transition	NOUN
gs-4321	310	16	before	before	SCONJ
gs-4321	310	17	resistance	resistance	NOUN
gs-4321	310	18	becomes	become	VERB
gs-4321	310	19	irreversible	irreversible	ADJ
gs-4321	310	20	.	.	PUNCT
gs-4321	311	1	population	population	NOUN
gs-4321	311	2	-	-	PUNCT
gs-4321	311	3	level	level	NOUN
gs-4321	311	4	consequences	consequence	NOUN
gs-4321	311	5	of	of	ADP
gs-4321	311	6	plasticity	plasticity	NOUN
gs-4321	311	7	phenotypic	phenotypic	ADJ
gs-4321	311	8	flexibility	flexibility	NOUN
gs-4321	311	9	affects	affect	VERB
gs-4321	311	10	not	not	PART
gs-4321	311	11	only	only	ADV
gs-4321	311	12	individual	individual	ADJ
gs-4321	311	13	cells	cell	NOUN
gs-4321	311	14	but	but	CCONJ
gs-4321	311	15	also	also	ADV
gs-4321	311	16	population	population	NOUN
gs-4321	311	17	-	-	PUNCT
gs-4321	311	18	level	level	NOUN
gs-4321	311	19	dynamics	dynamic	NOUN
gs-4321	311	20	,	,	PUNCT
gs-4321	311	21	influencing	influence	VERB
gs-4321	311	22	clonal	clonal	ADJ
gs-4321	311	23	expansion	expansion	NOUN
gs-4321	311	24	,	,	PUNCT
gs-4321	311	25	niche	niche	NOUN
gs-4321	311	26	competition	competition	NOUN
gs-4321	311	27	,	,	PUNCT
gs-4321	311	28	and	and	CCONJ
gs-4321	311	29	tumor	tumor	NOUN
gs-4321	311	30	evolution	evolution	NOUN
gs-4321	311	31	.	.	PUNCT
gs-4321	312	1	models	model	NOUN
gs-4321	312	2	combining	combine	VERB
gs-4321	312	3	evolutionary	evolutionary	ADJ
gs-4321	312	4	theory	theory	NOUN
gs-4321	312	5	with	with	ADP
gs-4321	312	6	single	single	ADJ
gs-4321	312	7	-	-	PUNCT
gs-4321	312	8	cell	cell	NOUN
gs-4321	312	9	data	datum	NOUN
gs-4321	312	10	demonstrate	demonstrate	VERB
gs-4321	312	11	that	that	SCONJ
gs-4321	312	12	plastic	plastic	ADJ
gs-4321	312	13	subpopulations	subpopulation	NOUN
gs-4321	312	14	often	often	ADV
gs-4321	312	15	act	act	VERB
gs-4321	312	16	as	as	ADP
gs-4321	312	17	“	"	PUNCT
gs-4321	312	18	ecological	ecological	ADJ
gs-4321	312	19	pioneers	pioneer	NOUN
gs-4321	312	20	,	,	PUNCT
gs-4321	312	21	”	"	PUNCT
gs-4321	312	22	enabling	enable	VERB
gs-4321	312	23	tumors	tumor	NOUN
gs-4321	312	24	to	to	PART
gs-4321	312	25	adapt	adapt	VERB
gs-4321	312	26	to	to	ADP
gs-4321	312	27	new	new	ADJ
gs-4321	312	28	environments	environment	NOUN
gs-4321	312	29	,	,	PUNCT
gs-4321	312	30	colonize	colonize	VERB
gs-4321	312	31	distal	distal	ADJ
gs-4321	312	32	sites	site	NOUN
gs-4321	312	33	,	,	PUNCT
gs-4321	312	34	and	and	CCONJ
gs-4321	312	35	withstand	withstand	VERB
gs-4321	312	36	therapeutic	therapeutic	ADJ
gs-4321	312	37	interventions	intervention	NOUN
gs-4321	312	38	.	.	PUNCT
gs-4321	313	1	bioinformatic	bioinformatic	ADJ
gs-4321	313	2	approaches	approach	NOUN
gs-4321	313	3	that	that	PRON
gs-4321	313	4	integrate	integrate	VERB
gs-4321	313	5	evolutionary	evolutionary	ADJ
gs-4321	313	6	inference	inference	NOUN
gs-4321	313	7	,	,	PUNCT
gs-4321	313	8	communication	communication	NOUN
gs-4321	313	9	modeling	modeling	NOUN
gs-4321	313	10	,	,	PUNCT
gs-4321	313	11	and	and	CCONJ
gs-4321	313	12	state	state	NOUN
gs-4321	313	13	-	-	PUNCT
gs-4321	313	14	transition	transition	NOUN
gs-4321	313	15	dynamics	dynamic	NOUN
gs-4321	313	16	provide	provide	VERB
gs-4321	313	17	a	a	DET
gs-4321	313	18	comprehensive	comprehensive	ADJ
gs-4321	313	19	framework	framework	NOUN
gs-4321	313	20	for	for	ADP
gs-4321	313	21	understanding	understand	VERB
gs-4321	313	22	how	how	SCONJ
gs-4321	313	23	these	these	DET
gs-4321	313	24	behaviors	behavior	NOUN
gs-4321	313	25	emerge	emerge	VERB
gs-4321	313	26	.	.	PUNCT
gs-4321	314	1	intersections	intersection	NOUN
gs-4321	314	2	between	between	ADP
gs-4321	314	3	genetic	genetic	ADJ
gs-4321	314	4	diversity	diversity	NOUN
gs-4321	314	5	and	and	CCONJ
gs-4321	314	6	functional	functional	ADJ
gs-4321	314	7	plasticity	plasticity	NOUN
gs-4321	314	8	genetic	genetic	ADJ
gs-4321	314	9	heterogeneity	heterogeneity	NOUN
gs-4321	314	10	within	within	ADP
gs-4321	314	11	tumors	tumor	NOUN
gs-4321	314	12	provides	provide	VERB
gs-4321	314	13	a	a	DET
gs-4321	314	14	foundational	foundational	ADJ
gs-4321	314	15	substrate	substrate	NOUN
gs-4321	314	16	upon	upon	SCONJ
gs-4321	314	17	which	which	PRON
gs-4321	314	18	phenotypic	phenotypic	ADJ
gs-4321	314	19	diversity	diversity	NOUN
gs-4321	314	20	can	can	AUX
gs-4321	314	21	evolve	evolve	VERB
gs-4321	314	22	.	.	PUNCT
gs-4321	315	1	however	however	ADV
gs-4321	315	2	,	,	PUNCT
gs-4321	315	3	single	single	ADJ
gs-4321	315	4	-	-	PUNCT
gs-4321	315	5	cell	cell	NOUN
gs-4321	315	6	analyses	analysis	NOUN
gs-4321	315	7	have	have	AUX
gs-4321	315	8	revealed	reveal	VERB
gs-4321	315	9	that	that	SCONJ
gs-4321	315	10	phenotypic	phenotypic	ADJ
gs-4321	315	11	plasticity	plasticity	NOUN
gs-4321	315	12	extends	extend	VERB
gs-4321	315	13	far	far	ADV
gs-4321	315	14	beyond	beyond	ADP
gs-4321	315	15	differences	difference	NOUN
gs-4321	315	16	encoded	encode	VERB
gs-4321	315	17	at	at	ADP
gs-4321	315	18	the	the	DET
gs-4321	315	19	dna	dna	PROPN
gs-4321	315	20	level	level	NOUN
gs-4321	315	21	.	.	PUNCT
gs-4321	316	1	malignant	malignant	ADJ
gs-4321	316	2	cells	cell	NOUN
gs-4321	316	3	with	with	ADP
gs-4321	316	4	distinct	distinct	ADJ
gs-4321	316	5	genotypes	genotype	NOUN
gs-4321	316	6	often	often	ADV
gs-4321	316	7	converge	converge	VERB
gs-4321	316	8	on	on	ADP
gs-4321	316	9	similar	similar	ADJ
gs-4321	316	10	adaptive	adaptive	ADJ
gs-4321	316	11	states	state	NOUN
gs-4321	316	12	,	,	PUNCT
gs-4321	316	13	while	while	SCONJ
gs-4321	316	14	genetically	genetically	ADV
gs-4321	316	15	identical	identical	ADJ
gs-4321	316	16	cells	cell	NOUN
gs-4321	316	17	can	can	AUX
gs-4321	316	18	diverge	diverge	VERB
gs-4321	316	19	into	into	ADP
gs-4321	316	20	multiple	multiple	ADJ
gs-4321	316	21	phenotypes	phenotype	NOUN
gs-4321	316	22	depending	depend	VERB
gs-4321	316	23	on	on	ADP
gs-4321	316	24	microenvironmental	microenvironmental	ADJ
gs-4321	316	25	or	or	CCONJ
gs-4321	316	26	regulatory	regulatory	ADJ
gs-4321	316	27	influences	influence	NOUN
gs-4321	316	28	(	(	PUNCT
gs-4321	316	29	raj	raj	NOUN
gs-4321	316	30	et	et	PROPN
gs-4321	316	31	al	al	PROPN
gs-4321	316	32	.	.	PROPN
gs-4321	316	33	,	,	PUNCT
gs-4321	316	34	2010	2010	NUM
gs-4321	316	35	;	;	PUNCT
gs-4321	316	36	francis	francis	PROPN
gs-4321	316	37	et	et	PROPN
gs-4321	316	38	al	al	PROPN
gs-4321	316	39	.	.	PROPN
gs-4321	316	40	,	,	PUNCT
gs-4321	316	41	2019	2019	NUM
gs-4321	316	42	)	)	PUNCT
gs-4321	316	43	.	.	PUNCT
gs-4321	317	1	this	this	DET
gs-4321	317	2	decoupling	decouple	VERB
gs-4321	317	3	between	between	ADP
gs-4321	317	4	genotype	genotype	NOUN
gs-4321	317	5	and	and	CCONJ
gs-4321	317	6	phenotype	phenotype	NOUN
gs-4321	317	7	underscores	underscore	VERB
gs-4321	317	8	the	the	DET
gs-4321	317	9	importance	importance	NOUN
gs-4321	317	10	of	of	ADP
gs-4321	317	11	bioinformatic	bioinformatic	ADJ
gs-4321	317	12	approaches	approach	NOUN
gs-4321	317	13	capable	capable	ADJ
gs-4321	317	14	georgian	georgian	NOUN
gs-4321	317	15	scientists/	scientists/	NUM
gs-4321	317	16	.	.	PUNCT
gs-4321	318	1	7	7	NUM
gs-4321	318	2	n	n	DET
gs-4321	318	3	4	4	NUM
gs-4321	318	4	,	,	PUNCT
gs-4321	318	5	2025	2025	NUM
gs-4321	318	6	353	353	NUM
gs-4321	318	7	of	of	ADP
gs-4321	318	8	integrating	integrate	VERB
gs-4321	318	9	transcriptional	transcriptional	ADJ
gs-4321	318	10	,	,	PUNCT
gs-4321	318	11	epigenetic	epigenetic	ADJ
gs-4321	318	12	,	,	PUNCT
gs-4321	318	13	and	and	CCONJ
gs-4321	318	14	environmental	environmental	ADJ
gs-4321	318	15	information	information	NOUN
gs-4321	319	1	to	to	PART
gs-4321	319	2	fully	fully	ADV
gs-4321	319	3	understand	understand	VERB
gs-4321	319	4	the	the	DET
gs-4321	319	5	drivers	driver	NOUN
gs-4321	319	6	of	of	ADP
gs-4321	319	7	cellular	cellular	ADJ
gs-4321	319	8	behavior	behavior	NOUN
gs-4321	319	9	.	.	PUNCT
gs-4321	320	1	genetic	genetic	ADJ
gs-4321	320	2	diversification	diversification	NOUN
gs-4321	320	3	may	may	AUX
gs-4321	320	4	nevertheless	nevertheless	ADV
gs-4321	320	5	influence	influence	VERB
gs-4321	320	6	adaptive	adaptive	ADJ
gs-4321	320	7	potential	potential	NOUN
gs-4321	320	8	.	.	PUNCT
gs-4321	321	1	specific	specific	ADJ
gs-4321	321	2	mutations	mutation	NOUN
gs-4321	321	3	—	—	PUNCT
gs-4321	321	4	such	such	ADJ
gs-4321	321	5	as	as	ADP
gs-4321	321	6	those	those	PRON
gs-4321	321	7	affecting	affect	VERB
gs-4321	321	8	chromatin	chromatin	NOUN
gs-4321	321	9	remodelers	remodeler	NOUN
gs-4321	321	10	,	,	PUNCT
gs-4321	321	11	transcriptional	transcriptional	ADJ
gs-4321	321	12	regulators	regulator	NOUN
gs-4321	321	13	,	,	PUNCT
gs-4321	321	14	or	or	CCONJ
gs-4321	321	15	signaling	signal	VERB
gs-4321	321	16	pathway	pathway	NOUN
gs-4321	321	17	components	component	NOUN
gs-4321	321	18	—	—	PUNCT
gs-4321	321	19	can	can	AUX
gs-4321	321	20	increase	increase	VERB
gs-4321	321	21	the	the	DET
gs-4321	321	22	likelihood	likelihood	NOUN
gs-4321	321	23	that	that	SCONJ
gs-4321	321	24	cells	cell	NOUN
gs-4321	321	25	switch	switch	VERB
gs-4321	321	26	into	into	ADP
gs-4321	321	27	stem	stem	NOUN
gs-4321	321	28	-	-	PUNCT
gs-4321	321	29	like	like	ADJ
gs-4321	321	30	or	or	CCONJ
gs-4321	321	31	therapy	therapy	NOUN
gs-4321	321	32	-	-	PUNCT
gs-4321	321	33	resistant	resistant	ADJ
gs-4321	321	34	states	state	NOUN
gs-4321	321	35	.	.	PUNCT
gs-4321	322	1	for	for	ADP
gs-4321	322	2	example	example	NOUN
gs-4321	322	3	,	,	PUNCT
gs-4321	322	4	mutations	mutation	NOUN
gs-4321	322	5	in	in	ADP
gs-4321	322	6	tp53	tp53	PROPN
gs-4321	322	7	,	,	PUNCT
gs-4321	322	8	swi	swi	PROPN
gs-4321	322	9	/	/	SYM
gs-4321	322	10	snf	snf	PROPN
gs-4321	322	11	complex	complex	ADJ
gs-4321	322	12	genes	gene	NOUN
gs-4321	322	13	,	,	PUNCT
gs-4321	322	14	and	and	CCONJ
gs-4321	322	15	epigenetic	epigenetic	ADJ
gs-4321	322	16	modifiers	modifier	NOUN
gs-4321	322	17	like	like	ADP
gs-4321	322	18	dnmt3a	dnmt3a	NOUN
gs-4321	322	19	and	and	CCONJ
gs-4321	322	20	tet2	tet2	PROPN
gs-4321	322	21	have	have	AUX
gs-4321	322	22	been	be	AUX
gs-4321	322	23	associated	associate	VERB
gs-4321	322	24	with	with	ADP
gs-4321	322	25	heightened	heightened	ADJ
gs-4321	322	26	transcriptional	transcriptional	ADJ
gs-4321	322	27	entropy	entropy	NOUN
gs-4321	322	28	and	and	CCONJ
gs-4321	322	29	increased	increase	VERB
gs-4321	322	30	plasticity	plasticity	NOUN
gs-4321	322	31	across	across	ADP
gs-4321	322	32	multiple	multiple	ADJ
gs-4321	322	33	cancers	cancer	NOUN
gs-4321	322	34	(	(	PUNCT
gs-4321	322	35	finnerty	finnerty	PROPN
gs-4321	322	36	et	et	PROPN
gs-4321	322	37	al	al	PROPN
gs-4321	322	38	.	.	PROPN
gs-4321	322	39	,	,	PUNCT
gs-4321	322	40	2022	2022	NUM
gs-4321	322	41	;	;	PUNCT
gs-4321	322	42	rheinbay	rheinbay	PROPN
gs-4321	322	43	et	et	PROPN
gs-4321	322	44	al	al	PROPN
gs-4321	322	45	.	.	PROPN
gs-4321	322	46	,	,	PUNCT
gs-4321	322	47	2020	2020	NUM
gs-4321	322	48	)	)	PUNCT
gs-4321	322	49	.	.	PUNCT
gs-4321	323	1	computational	computational	ADJ
gs-4321	323	2	methods	method	NOUN
gs-4321	323	3	combining	combine	VERB
gs-4321	323	4	single	single	ADJ
gs-4321	323	5	-	-	PUNCT
gs-4321	323	6	cell	cell	NOUN
gs-4321	323	7	rna	rna	NOUN
gs-4321	323	8	,	,	PUNCT
gs-4321	323	9	atac	atac	ADJ
gs-4321	323	10	,	,	PUNCT
gs-4321	323	11	and	and	CCONJ
gs-4321	323	12	dna	dna	PROPN
gs-4321	323	13	sequencing	sequence	VERB
gs-4321	323	14	data	datum	NOUN
gs-4321	323	15	allow	allow	VERB
gs-4321	323	16	researchers	researcher	NOUN
gs-4321	323	17	to	to	PART
gs-4321	323	18	map	map	VERB
gs-4321	323	19	the	the	DET
gs-4321	323	20	interactions	interaction	NOUN
gs-4321	323	21	between	between	ADP
gs-4321	323	22	genetic	genetic	ADJ
gs-4321	323	23	lesions	lesion	NOUN
gs-4321	323	24	and	and	CCONJ
gs-4321	323	25	adaptive	adaptive	ADJ
gs-4321	323	26	programs	program	NOUN
gs-4321	323	27	more	more	ADV
gs-4321	323	28	precisely	precisely	ADV
gs-4321	323	29	than	than	ADP
gs-4321	323	30	ever	ever	ADV
gs-4321	323	31	before	before	ADV
gs-4321	323	32	.	.	PUNCT
gs-4321	324	1	stochastic	stochastic	ADJ
gs-4321	324	2	fluctuations	fluctuation	NOUN
gs-4321	324	3	and	and	CCONJ
gs-4321	324	4	non	non	ADJ
gs-4321	324	5	-	-	ADJ
gs-4321	324	6	genetic	genetic	ADJ
gs-4321	324	7	variability	variability	NOUN
gs-4321	324	8	beyond	beyond	ADP
gs-4321	324	9	deterministic	deterministic	ADJ
gs-4321	324	10	genetic	genetic	ADJ
gs-4321	324	11	and	and	CCONJ
gs-4321	324	12	microenvironmental	microenvironmental	ADJ
gs-4321	324	13	influences	influence	NOUN
gs-4321	324	14	,	,	PUNCT
gs-4321	324	15	malignant	malignant	ADJ
gs-4321	324	16	cells	cell	NOUN
gs-4321	324	17	exhibit	exhibit	VERB
gs-4321	324	18	extensive	extensive	ADJ
gs-4321	324	19	non	non	ADJ
gs-4321	324	20	-	-	ADJ
gs-4321	324	21	genetic	genetic	ADJ
gs-4321	324	22	variability	variability	NOUN
gs-4321	324	23	that	that	PRON
gs-4321	324	24	arises	arise	VERB
gs-4321	324	25	from	from	ADP
gs-4321	324	26	stochastic	stochastic	ADJ
gs-4321	324	27	fluctuations	fluctuation	NOUN
gs-4321	324	28	in	in	ADP
gs-4321	324	29	transcription	transcription	NOUN
gs-4321	324	30	,	,	PUNCT
gs-4321	324	31	translation	translation	NOUN
gs-4321	324	32	,	,	PUNCT
gs-4321	324	33	and	and	CCONJ
gs-4321	324	34	intracellular	intracellular	ADJ
gs-4321	324	35	signaling	signaling	NOUN
gs-4321	324	36	.	.	PUNCT
gs-4321	325	1	these	these	DET
gs-4321	325	2	random	random	ADJ
gs-4321	325	3	fluctuations	fluctuation	NOUN
gs-4321	325	4	can	can	AUX
gs-4321	325	5	generate	generate	VERB
gs-4321	325	6	transient	transient	ADJ
gs-4321	325	7	subpopulations	subpopulation	NOUN
gs-4321	325	8	with	with	ADP
gs-4321	325	9	increased	increase	VERB
gs-4321	325	10	survival	survival	NOUN
gs-4321	325	11	capacity	capacity	NOUN
gs-4321	325	12	or	or	CCONJ
gs-4321	325	13	altered	alter	VERB
gs-4321	325	14	lineage	lineage	NOUN
gs-4321	325	15	potential	potential	NOUN
gs-4321	325	16	(	(	PUNCT
gs-4321	325	17	balázsi	balázsi	NOUN
gs-4321	325	18	et	et	PROPN
gs-4321	325	19	al	al	PROPN
gs-4321	325	20	.	.	PROPN
gs-4321	325	21	,	,	PUNCT
gs-4321	325	22	2011	2011	NUM
gs-4321	325	23	)	)	PUNCT
gs-4321	325	24	.	.	PUNCT
gs-4321	326	1	single	single	ADJ
gs-4321	326	2	-	-	PUNCT
gs-4321	326	3	cell	cell	NOUN
gs-4321	326	4	bioinformatic	bioinformatic	ADJ
gs-4321	326	5	methods	method	NOUN
gs-4321	326	6	,	,	PUNCT
gs-4321	326	7	including	include	VERB
gs-4321	326	8	variability	variability	NOUN
gs-4321	326	9	scoring	scoring	NOUN
gs-4321	326	10	,	,	PUNCT
gs-4321	326	11	transcriptional	transcriptional	ADJ
gs-4321	326	12	noise	noise	NOUN
gs-4321	326	13	quantification	quantification	NOUN
gs-4321	326	14	,	,	PUNCT
gs-4321	326	15	and	and	CCONJ
gs-4321	326	16	entropy	entropy	VERB
gs-4321	326	17	analysis	analysis	NOUN
gs-4321	326	18	,	,	PUNCT
gs-4321	326	19	offer	offer	VERB
gs-4321	326	20	quantitative	quantitative	ADJ
gs-4321	326	21	frameworks	framework	NOUN
gs-4321	326	22	for	for	ADP
gs-4321	326	23	measuring	measure	VERB
gs-4321	326	24	these	these	DET
gs-4321	326	25	fluctuations	fluctuation	NOUN
gs-4321	326	26	.	.	PUNCT
gs-4321	327	1	such	such	ADJ
gs-4321	327	2	analyses	analysis	NOUN
gs-4321	327	3	have	have	AUX
gs-4321	327	4	shown	show	VERB
gs-4321	327	5	that	that	SCONJ
gs-4321	327	6	cells	cell	NOUN
gs-4321	327	7	with	with	ADP
gs-4321	327	8	higher	high	ADJ
gs-4321	327	9	transcriptional	transcriptional	NOUN
gs-4321	327	10	noise	noise	NOUN
gs-4321	327	11	frequently	frequently	ADV
gs-4321	327	12	occupy	occupy	VERB
gs-4321	327	13	or	or	CCONJ
gs-4321	327	14	transition	transition	NOUN
gs-4321	327	15	toward	toward	ADP
gs-4321	327	16	adaptable	adaptable	ADJ
gs-4321	327	17	intermediate	intermediate	ADJ
gs-4321	327	18	states	state	NOUN
gs-4321	327	19	.	.	PUNCT
gs-4321	328	1	moreover	moreover	ADV
gs-4321	328	2	,	,	PUNCT
gs-4321	328	3	stochastic	stochastic	ADJ
gs-4321	328	4	variability	variability	NOUN
gs-4321	328	5	may	may	AUX
gs-4321	328	6	enable	enable	VERB
gs-4321	328	7	rapid	rapid	ADJ
gs-4321	328	8	exploration	exploration	NOUN
gs-4321	328	9	of	of	ADP
gs-4321	328	10	phenotypic	phenotypic	ADJ
gs-4321	328	11	landscapes	landscape	NOUN
gs-4321	328	12	,	,	PUNCT
gs-4321	328	13	allowing	allow	VERB
gs-4321	328	14	tumors	tumor	NOUN
gs-4321	328	15	to	to	PART
gs-4321	328	16	identify	identify	VERB
gs-4321	328	17	and	and	CCONJ
gs-4321	328	18	amplify	amplify	VERB
gs-4321	328	19	cell	cell	NOUN
gs-4321	328	20	states	state	NOUN
gs-4321	328	21	that	that	PRON
gs-4321	328	22	confer	confer	VERB
gs-4321	328	23	selective	selective	ADJ
gs-4321	328	24	advantages	advantage	NOUN
gs-4321	328	25	.	.	PUNCT
gs-4321	329	1	this	this	DET
gs-4321	329	2	“	"	PUNCT
gs-4321	329	3	bet	bet	ADJ
gs-4321	329	4	-	-	PUNCT
gs-4321	329	5	hedging	hedging	NOUN
gs-4321	329	6	”	"	PUNCT
gs-4321	329	7	strategy	strategy	NOUN
gs-4321	329	8	has	have	AUX
gs-4321	329	9	been	be	AUX
gs-4321	329	10	documented	document	VERB
gs-4321	329	11	in	in	ADP
gs-4321	329	12	microbial	microbial	ADJ
gs-4321	329	13	systems	system	NOUN
gs-4321	329	14	and	and	CCONJ
gs-4321	329	15	is	be	AUX
gs-4321	329	16	increasingly	increasingly	ADV
gs-4321	329	17	recognized	recognize	VERB
gs-4321	329	18	as	as	ADP
gs-4321	329	19	relevant	relevant	ADJ
gs-4321	329	20	in	in	ADP
gs-4321	329	21	cancer	cancer	NOUN
gs-4321	329	22	biology	biology	NOUN
gs-4321	329	23	.	.	PUNCT
gs-4321	330	1	computational	computational	ADJ
gs-4321	330	2	modeling	modeling	NOUN
gs-4321	330	3	that	that	PRON
gs-4321	330	4	incorporates	incorporate	VERB
gs-4321	330	5	stochasticity	stochasticity	NOUN
gs-4321	330	6	alongside	alongside	ADP
gs-4321	330	7	deterministic	deterministic	ADJ
gs-4321	330	8	regulatory	regulatory	ADJ
gs-4321	330	9	rules	rule	NOUN
gs-4321	330	10	provides	provide	VERB
gs-4321	330	11	a	a	DET
gs-4321	330	12	more	more	ADV
gs-4321	330	13	complete	complete	ADJ
gs-4321	330	14	representation	representation	NOUN
gs-4321	330	15	of	of	ADP
gs-4321	330	16	tumor	tumor	NOUN
gs-4321	330	17	dynamics	dynamic	NOUN
gs-4321	330	18	.	.	PUNCT
gs-4321	331	1	plasticity	plasticity	NOUN
gs-4321	331	2	and	and	CCONJ
gs-4321	331	3	metastatic	metastatic	ADJ
gs-4321	331	4	competence	competence	NOUN
gs-4321	331	5	phenotypic	phenotypic	NOUN
gs-4321	331	6	plasticity	plasticity	NOUN
gs-4321	331	7	is	be	AUX
gs-4321	331	8	closely	closely	ADV
gs-4321	331	9	linked	link	VERB
gs-4321	331	10	with	with	ADP
gs-4321	331	11	metastatic	metastatic	ADJ
gs-4321	331	12	potential	potential	NOUN
gs-4321	331	13	across	across	ADP
gs-4321	331	14	cancer	cancer	NOUN
gs-4321	331	15	types	type	NOUN
gs-4321	331	16	.	.	PUNCT
gs-4321	332	1	adaptable	adaptable	ADJ
gs-4321	332	2	cells	cell	NOUN
gs-4321	332	3	often	often	ADV
gs-4321	332	4	possess	possess	VERB
gs-4321	332	5	the	the	DET
gs-4321	332	6	capacity	capacity	NOUN
gs-4321	332	7	to	to	PART
gs-4321	332	8	detach	detach	VERB
gs-4321	332	9	,	,	PUNCT
gs-4321	332	10	survive	survive	VERB
gs-4321	332	11	in	in	ADP
gs-4321	332	12	circulation	circulation	NOUN
gs-4321	332	13	,	,	PUNCT
gs-4321	332	14	and	and	CCONJ
gs-4321	332	15	colonize	colonize	VERB
gs-4321	332	16	distant	distant	ADJ
gs-4321	332	17	tissues	tissue	NOUN
gs-4321	332	18	.	.	PUNCT
gs-4321	333	1	single	single	ADJ
gs-4321	333	2	-	-	PUNCT
gs-4321	333	3	cell	cell	NOUN
gs-4321	333	4	analyses	analysis	NOUN
gs-4321	333	5	have	have	AUX
gs-4321	333	6	revealed	reveal	VERB
gs-4321	333	7	that	that	SCONJ
gs-4321	333	8	metastatic	metastatic	ADJ
gs-4321	333	9	seeding	seeding	NOUN
gs-4321	333	10	frequently	frequently	ADV
gs-4321	333	11	originates	originate	NOUN
gs-4321	333	12	from	from	ADP
gs-4321	333	13	subpopulations	subpopulation	NOUN
gs-4321	333	14	exhibiting	exhibit	VERB
gs-4321	333	15	hybrid	hybrid	ADJ
gs-4321	333	16	epithelial	epithelial	ADJ
gs-4321	333	17	–	–	PUNCT
gs-4321	333	18	mesenchymal	mesenchymal	ADJ
gs-4321	333	19	features	feature	NOUN
gs-4321	333	20	,	,	PUNCT
gs-4321	333	21	stressinduced	stressinduced	ADJ
gs-4321	333	22	programs	program	NOUN
gs-4321	333	23	,	,	PUNCT
gs-4321	333	24	and	and	CCONJ
gs-4321	333	25	enhanced	enhance	VERB
gs-4321	333	26	stem	stem	NOUN
gs-4321	333	27	-	-	PUNCT
gs-4321	333	28	associated	associate	VERB
gs-4321	333	29	signatures	signature	NOUN
gs-4321	333	30	(	(	PUNCT
gs-4321	333	31	pastushenko	pastushenko	NOUN
gs-4321	333	32	et	et	PROPN
gs-4321	333	33	al	al	PROPN
gs-4321	333	34	.	.	PROPN
gs-4321	333	35	,	,	PUNCT
gs-4321	333	36	2018	2018	NUM
gs-4321	333	37	;	;	PUNCT
gs-4321	333	38	dongre	dongre	NOUN
gs-4321	333	39	and	and	CCONJ
gs-4321	333	40	weinberg	weinberg	PROPN
gs-4321	333	41	,	,	PUNCT
gs-4321	333	42	2019	2019	NUM
gs-4321	333	43	)	)	PUNCT
gs-4321	333	44	.	.	PUNCT
gs-4321	334	1	these	these	DET
gs-4321	334	2	findings	finding	NOUN
gs-4321	334	3	highlight	highlight	VERB
gs-4321	334	4	that	that	SCONJ
gs-4321	334	5	metastatic	metastatic	ADJ
gs-4321	334	6	competence	competence	NOUN
gs-4321	334	7	is	be	AUX
gs-4321	334	8	not	not	PART
gs-4321	334	9	simply	simply	ADV
gs-4321	334	10	a	a	DET
gs-4321	334	11	trait	trait	NOUN
gs-4321	334	12	of	of	ADP
gs-4321	334	13	terminally	terminally	ADV
gs-4321	334	14	differentiated	differentiate	VERB
gs-4321	334	15	invasive	invasive	ADJ
gs-4321	334	16	cells	cell	NOUN
gs-4321	334	17	but	but	CCONJ
gs-4321	334	18	may	may	AUX
gs-4321	334	19	arise	arise	VERB
gs-4321	334	20	through	through	ADP
gs-4321	334	21	dynamic	dynamic	ADJ
gs-4321	334	22	and	and	CCONJ
gs-4321	334	23	reversible	reversible	ADJ
gs-4321	334	24	transitions	transition	NOUN
gs-4321	334	25	.	.	PUNCT
gs-4321	335	1	bioinformatic	bioinformatic	ADJ
gs-4321	335	2	integration	integration	NOUN
gs-4321	335	3	of	of	ADP
gs-4321	335	4	trajectory	trajectory	NOUN
gs-4321	335	5	,	,	PUNCT
gs-4321	335	6	grn	grn	PROPN
gs-4321	335	7	,	,	PUNCT
gs-4321	335	8	and	and	CCONJ
gs-4321	335	9	communication	communication	NOUN
gs-4321	335	10	analyses	analysis	NOUN
gs-4321	335	11	allows	allow	VERB
gs-4321	335	12	identification	identification	NOUN
gs-4321	335	13	of	of	ADP
gs-4321	335	14	subpopulations	subpopulation	NOUN
gs-4321	335	15	with	with	ADP
gs-4321	335	16	heightened	heightened	ADJ
gs-4321	335	17	metastatic	metastatic	ADJ
gs-4321	335	18	potential	potential	NOUN
gs-4321	335	19	.	.	PUNCT
gs-4321	336	1	for	for	ADP
gs-4321	336	2	instance	instance	NOUN
gs-4321	336	3	,	,	PUNCT
gs-4321	336	4	inference	inference	NOUN
gs-4321	336	5	of	of	ADP
gs-4321	336	6	regulons	regulon	NOUN
gs-4321	336	7	associated	associate	VERB
gs-4321	336	8	with	with	ADP
gs-4321	336	9	invasion	invasion	NOUN
gs-4321	336	10	or	or	CCONJ
gs-4321	336	11	dissemination	dissemination	NOUN
gs-4321	336	12	can	can	AUX
gs-4321	336	13	reveal	reveal	VERB
gs-4321	336	14	early	early	ADV
gs-4321	336	15	priming	prime	VERB
gs-4321	336	16	georgian	georgian	NOUN
gs-4321	336	17	scientists/	scientists/	NUM
gs-4321	336	18	.	.	PUNCT
gs-4321	337	1	7	7	NUM
gs-4321	337	2	n	n	DET
gs-4321	337	3	4	4	NUM
gs-4321	337	4	,	,	PUNCT
gs-4321	337	5	2025	2025	NUM
gs-4321	337	6	354	354	NUM
gs-4321	337	7	events	event	NOUN
gs-4321	337	8	that	that	PRON
gs-4321	337	9	precede	precede	VERB
gs-4321	337	10	overt	overt	ADJ
gs-4321	337	11	metastatic	metastatic	ADJ
gs-4321	337	12	behavior	behavior	NOUN
gs-4321	337	13	.	.	PUNCT
gs-4321	338	1	likewise	likewise	ADV
gs-4321	338	2	,	,	PUNCT
gs-4321	338	3	communication	communication	NOUN
gs-4321	338	4	inference	inference	NOUN
gs-4321	338	5	can	can	AUX
gs-4321	338	6	pinpoint	pinpoint	VERB
gs-4321	338	7	microenvironmental	microenvironmental	ADJ
gs-4321	338	8	cues	cue	NOUN
gs-4321	338	9	—	—	PUNCT
gs-4321	338	10	such	such	ADJ
gs-4321	338	11	as	as	ADP
gs-4321	338	12	macrophage	macrophage	NOUN
gs-4321	338	13	-	-	PUNCT
gs-4321	338	14	derived	derive	VERB
gs-4321	338	15	egf	egf	NOUN
gs-4321	338	16	or	or	CCONJ
gs-4321	338	17	fibroblastderived	fibroblastderive	VERB
gs-4321	338	18	cxcl12	cxcl12	ADJ
gs-4321	338	19	—	—	PUNCT
gs-4321	338	20	that	that	PRON
gs-4321	338	21	enhance	enhance	VERB
gs-4321	338	22	metastatic	metastatic	ADJ
gs-4321	338	23	readiness	readiness	NOUN
gs-4321	338	24	.	.	PUNCT
gs-4321	339	1	implications	implication	NOUN
gs-4321	339	2	for	for	ADP
gs-4321	339	3	therapeutic	therapeutic	ADJ
gs-4321	339	4	targeting	targeting	NOUN
gs-4321	339	5	understanding	understand	VERB
gs-4321	339	6	the	the	DET
gs-4321	339	7	interplay	interplay	NOUN
gs-4321	339	8	between	between	ADP
gs-4321	339	9	genetic	genetic	ADJ
gs-4321	339	10	,	,	PUNCT
gs-4321	339	11	epigenetic	epigenetic	ADJ
gs-4321	339	12	,	,	PUNCT
gs-4321	339	13	stochastic	stochastic	NOUN
gs-4321	339	14	,	,	PUNCT
gs-4321	339	15	and	and	CCONJ
gs-4321	339	16	microenvironmental	microenvironmental	ADJ
gs-4321	339	17	influences	influence	NOUN
gs-4321	339	18	on	on	ADP
gs-4321	339	19	cellular	cellular	ADJ
gs-4321	339	20	plasticity	plasticity	NOUN
gs-4321	339	21	is	be	AUX
gs-4321	339	22	essential	essential	ADJ
gs-4321	339	23	for	for	ADP
gs-4321	339	24	developing	develop	VERB
gs-4321	339	25	new	new	ADJ
gs-4321	339	26	therapeutic	therapeutic	ADJ
gs-4321	339	27	strategies	strategy	NOUN
gs-4321	339	28	.	.	PUNCT
gs-4321	340	1	adaptive	adaptive	ADJ
gs-4321	340	2	behaviors	behavior	NOUN
gs-4321	340	3	frequently	frequently	ADV
gs-4321	340	4	underlie	underlie	VERB
gs-4321	340	5	resistance	resistance	NOUN
gs-4321	340	6	to	to	ADP
gs-4321	340	7	targeted	target	VERB
gs-4321	340	8	therapies	therapy	NOUN
gs-4321	340	9	,	,	PUNCT
gs-4321	340	10	immunotherapies	immunotherapy	NOUN
gs-4321	340	11	,	,	PUNCT
gs-4321	340	12	and	and	CCONJ
gs-4321	340	13	chemotherapeutics	chemotherapeutic	NOUN
gs-4321	340	14	.	.	PUNCT
gs-4321	341	1	by	by	ADP
gs-4321	341	2	identifying	identify	VERB
gs-4321	341	3	the	the	DET
gs-4321	341	4	regulators	regulator	NOUN
gs-4321	341	5	and	and	CCONJ
gs-4321	341	6	ecological	ecological	ADJ
gs-4321	341	7	dependencies	dependency	NOUN
gs-4321	341	8	of	of	ADP
gs-4321	341	9	plasticity	plasticity	NOUN
gs-4321	341	10	,	,	PUNCT
gs-4321	341	11	computational	computational	ADJ
gs-4321	341	12	single	single	ADJ
gs-4321	341	13	-	-	PUNCT
gs-4321	341	14	cell	cell	NOUN
gs-4321	341	15	methods	method	NOUN
gs-4321	341	16	provide	provide	VERB
gs-4321	341	17	a	a	DET
gs-4321	341	18	blueprint	blueprint	NOUN
gs-4321	341	19	for	for	ADP
gs-4321	341	20	rational	rational	ADJ
gs-4321	341	21	design	design	NOUN
gs-4321	341	22	of	of	ADP
gs-4321	341	23	interventions	intervention	NOUN
gs-4321	341	24	that	that	PRON
gs-4321	341	25	block	block	VERB
gs-4321	341	26	or	or	CCONJ
gs-4321	341	27	redirect	redirect	VERB
gs-4321	341	28	these	these	DET
gs-4321	341	29	transitions	transition	NOUN
gs-4321	341	30	.	.	PUNCT
gs-4321	342	1	whether	whether	SCONJ
gs-4321	342	2	such	such	ADJ
gs-4321	342	3	strategies	strategy	NOUN
gs-4321	342	4	target	target	VERB
gs-4321	342	5	transcriptional	transcriptional	ADJ
gs-4321	342	6	regulators	regulator	NOUN
gs-4321	342	7	,	,	PUNCT
gs-4321	342	8	epigenetic	epigenetic	ADJ
gs-4321	342	9	modifiers	modifier	NOUN
gs-4321	342	10	,	,	PUNCT
gs-4321	342	11	metabolic	metabolic	NOUN
gs-4321	342	12	pathways	pathway	NOUN
gs-4321	342	13	,	,	PUNCT
gs-4321	342	14	or	or	CCONJ
gs-4321	342	15	cell	cell	NOUN
gs-4321	342	16	–	–	PUNCT
gs-4321	342	17	cell	cell	NOUN
gs-4321	342	18	communication	communication	NOUN
gs-4321	342	19	networks	network	NOUN
gs-4321	342	20	,	,	PUNCT
gs-4321	342	21	their	their	PRON
gs-4321	342	22	success	success	NOUN
gs-4321	342	23	depends	depend	VERB
gs-4321	342	24	on	on	ADP
gs-4321	342	25	precisely	precisely	ADV
gs-4321	342	26	mapping	map	VERB
gs-4321	342	27	the	the	DET
gs-4321	342	28	dynamic	dynamic	ADJ
gs-4321	342	29	states	state	NOUN
gs-4321	342	30	that	that	SCONJ
gs-4321	342	31	malignant	malignant	ADJ
gs-4321	342	32	cells	cell	NOUN
gs-4321	342	33	traverse	traverse	VERB
gs-4321	342	34	.	.	PUNCT
gs-4321	343	1	therapy	therapy	NOUN
gs-4321	343	2	-	-	PUNCT
gs-4321	343	3	induced	induce	VERB
gs-4321	343	4	reprogramming	reprogramming	NOUN
gs-4321	343	5	and	and	CCONJ
gs-4321	343	6	adaptive	adaptive	ADJ
gs-4321	343	7	resistance	resistance	NOUN
gs-4321	343	8	a	a	DET
gs-4321	343	9	major	major	ADJ
gs-4321	343	10	challenge	challenge	NOUN
gs-4321	343	11	in	in	ADP
gs-4321	343	12	oncology	oncology	NOUN
gs-4321	343	13	is	be	AUX
gs-4321	343	14	the	the	DET
gs-4321	343	15	capacity	capacity	NOUN
gs-4321	343	16	of	of	ADP
gs-4321	343	17	malignant	malignant	ADJ
gs-4321	343	18	cells	cell	NOUN
gs-4321	343	19	to	to	PART
gs-4321	343	20	undergo	undergo	VERB
gs-4321	343	21	therapy	therapy	NOUN
gs-4321	343	22	-	-	PUNCT
gs-4321	343	23	induced	induced	ADJ
gs-4321	343	24	reprogramming	reprogramming	NOUN
gs-4321	343	25	that	that	PRON
gs-4321	343	26	enables	enable	VERB
gs-4321	343	27	survival	survival	NOUN
gs-4321	343	28	despite	despite	SCONJ
gs-4321	343	29	sustained	sustained	ADJ
gs-4321	343	30	drug	drug	NOUN
gs-4321	343	31	pressure	pressure	NOUN
gs-4321	343	32	.	.	PUNCT
gs-4321	344	1	single	single	ADJ
gs-4321	344	2	-	-	PUNCT
gs-4321	344	3	cell	cell	NOUN
gs-4321	344	4	studies	study	NOUN
gs-4321	344	5	have	have	AUX
gs-4321	344	6	repeatedly	repeatedly	ADV
gs-4321	344	7	shown	show	VERB
gs-4321	344	8	that	that	SCONJ
gs-4321	344	9	cytotoxic	cytotoxic	ADJ
gs-4321	344	10	agents	agent	NOUN
gs-4321	344	11	,	,	PUNCT
gs-4321	344	12	targeted	target	VERB
gs-4321	344	13	inhibitors	inhibitor	NOUN
gs-4321	344	14	,	,	PUNCT
gs-4321	344	15	and	and	CCONJ
gs-4321	344	16	immunotherapies	immunotherapy	NOUN
gs-4321	344	17	frequently	frequently	ADV
gs-4321	344	18	trigger	trigger	VERB
gs-4321	344	19	transitions	transition	NOUN
gs-4321	344	20	into	into	ADP
gs-4321	344	21	transient	transient	ADJ
gs-4321	344	22	adaptive	adaptive	ADJ
gs-4321	344	23	states	state	NOUN
gs-4321	344	24	that	that	PRON
gs-4321	344	25	precede	precede	VERB
gs-4321	344	26	stable	stable	ADJ
gs-4321	344	27	drug	drug	NOUN
gs-4321	344	28	resistance	resistance	NOUN
gs-4321	344	29	(	(	PUNCT
gs-4321	344	30	sharma	sharma	PROPN
gs-4321	344	31	et	et	PROPN
gs-4321	344	32	al	al	PROPN
gs-4321	344	33	.	.	PROPN
gs-4321	344	34	,	,	PUNCT
gs-4321	344	35	2010	2010	NUM
gs-4321	344	36	;	;	PUNCT
gs-4321	344	37	oren	oren	NOUN
gs-4321	344	38	et	et	PROPN
gs-4321	344	39	al	al	PROPN
gs-4321	344	40	.	.	PROPN
gs-4321	344	41	,	,	PUNCT
gs-4321	344	42	2021	2021	NUM
gs-4321	344	43	)	)	PUNCT
gs-4321	344	44	.	.	PUNCT
gs-4321	345	1	these	these	DET
gs-4321	345	2	transitional	transitional	ADJ
gs-4321	345	3	phenotypes	phenotype	NOUN
gs-4321	345	4	are	be	AUX
gs-4321	345	5	characterized	characterize	VERB
gs-4321	345	6	by	by	ADP
gs-4321	345	7	stress	stress	NOUN
gs-4321	345	8	-	-	PUNCT
gs-4321	345	9	responsive	responsive	ADJ
gs-4321	345	10	transcriptional	transcriptional	ADJ
gs-4321	345	11	programs	program	NOUN
gs-4321	345	12	,	,	PUNCT
gs-4321	345	13	altered	alter	VERB
gs-4321	345	14	cell	cell	NOUN
gs-4321	345	15	-	-	PUNCT
gs-4321	345	16	cycle	cycle	NOUN
gs-4321	345	17	dynamics	dynamic	NOUN
gs-4321	345	18	,	,	PUNCT
gs-4321	345	19	and	and	CCONJ
gs-4321	345	20	partial	partial	ADJ
gs-4321	345	21	activation	activation	NOUN
gs-4321	345	22	of	of	ADP
gs-4321	345	23	stem	stem	NOUN
gs-4321	345	24	-	-	PUNCT
gs-4321	345	25	associated	associate	VERB
gs-4321	345	26	networks	network	NOUN
gs-4321	345	27	.	.	PUNCT
gs-4321	346	1	importantly	importantly	ADV
gs-4321	346	2	,	,	PUNCT
gs-4321	346	3	these	these	DET
gs-4321	346	4	states	state	NOUN
gs-4321	346	5	are	be	AUX
gs-4321	346	6	reversible	reversible	ADJ
gs-4321	346	7	,	,	PUNCT
gs-4321	346	8	suggesting	suggest	VERB
gs-4321	346	9	that	that	SCONJ
gs-4321	346	10	resistance	resistance	NOUN
gs-4321	346	11	is	be	AUX
gs-4321	346	12	often	often	ADV
gs-4321	346	13	not	not	PART
gs-4321	346	14	the	the	DET
gs-4321	346	15	result	result	NOUN
gs-4321	346	16	of	of	ADP
gs-4321	346	17	fixed	fix	VERB
gs-4321	346	18	genetic	genetic	ADJ
gs-4321	346	19	changes	change	NOUN
gs-4321	346	20	but	but	CCONJ
gs-4321	346	21	arises	arise	VERB
gs-4321	346	22	through	through	ADP
gs-4321	346	23	coordinated	coordinated	ADJ
gs-4321	346	24	reorganization	reorganization	NOUN
gs-4321	346	25	of	of	ADP
gs-4321	346	26	regulatory	regulatory	ADJ
gs-4321	346	27	networks	network	NOUN
gs-4321	346	28	.	.	PUNCT
gs-4321	347	1	bioinformatic	bioinformatic	ADJ
gs-4321	347	2	trajectory	trajectory	NOUN
gs-4321	347	3	inference	inference	NOUN
gs-4321	347	4	,	,	PUNCT
gs-4321	347	5	regulatory	regulatory	ADJ
gs-4321	347	6	network	network	NOUN
gs-4321	347	7	analysis	analysis	NOUN
gs-4321	347	8	,	,	PUNCT
gs-4321	347	9	and	and	CCONJ
gs-4321	347	10	velocity	velocity	NOUN
gs-4321	347	11	-	-	PUNCT
gs-4321	347	12	based	base	VERB
gs-4321	347	13	modeling	modeling	NOUN
gs-4321	347	14	have	have	AUX
gs-4321	347	15	revealed	reveal	VERB
gs-4321	347	16	that	that	SCONJ
gs-4321	347	17	therapy	therapy	NOUN
gs-4321	347	18	-	-	PUNCT
gs-4321	347	19	induced	induce	VERB
gs-4321	347	20	transitions	transition	NOUN
gs-4321	347	21	unfold	unfold	VERB
gs-4321	347	22	in	in	ADP
gs-4321	347	23	distinct	distinct	ADJ
gs-4321	347	24	temporal	temporal	ADJ
gs-4321	347	25	phases	phase	NOUN
gs-4321	347	26	.	.	PUNCT
gs-4321	348	1	early	early	ADJ
gs-4321	348	2	phases	phase	NOUN
gs-4321	348	3	are	be	AUX
gs-4321	348	4	dominated	dominate	VERB
gs-4321	348	5	by	by	ADP
gs-4321	348	6	rapid	rapid	ADJ
gs-4321	348	7	induction	induction	NOUN
gs-4321	348	8	of	of	ADP
gs-4321	348	9	stress	stress	ADJ
gs-4321	348	10	pathways	pathway	NOUN
gs-4321	348	11	such	such	ADJ
gs-4321	348	12	as	as	ADP
gs-4321	348	13	atf4	atf4	PROPN
gs-4321	348	14	,	,	PUNCT
gs-4321	348	15	jnk	jnk	PROPN
gs-4321	348	16	,	,	PUNCT
gs-4321	348	17	and	and	CCONJ
gs-4321	348	18	stat3	stat3	NOUN
gs-4321	348	19	,	,	PUNCT
gs-4321	348	20	followed	follow	VERB
gs-4321	348	21	by	by	ADP
gs-4321	348	22	chromatin	chromatin	NOUN
gs-4321	348	23	remodeling	remodeling	NOUN
gs-4321	348	24	events	event	NOUN
gs-4321	348	25	that	that	PRON
gs-4321	348	26	establish	establish	VERB
gs-4321	348	27	new	new	ADJ
gs-4321	348	28	accessibility	accessibility	NOUN
gs-4321	348	29	landscapes	landscape	NOUN
gs-4321	348	30	.	.	PUNCT
gs-4321	349	1	subsequent	subsequent	ADJ
gs-4321	349	2	activation	activation	NOUN
gs-4321	349	3	of	of	ADP
gs-4321	349	4	lineage	lineage	NOUN
gs-4321	349	5	-	-	PUNCT
gs-4321	349	6	specifying	specify	VERB
gs-4321	349	7	transcription	transcription	NOUN
gs-4321	349	8	factors	factor	NOUN
gs-4321	349	9	reinforces	reinforce	VERB
gs-4321	349	10	survival	survival	NOUN
gs-4321	349	11	programs	program	NOUN
gs-4321	349	12	and	and	CCONJ
gs-4321	349	13	may	may	AUX
gs-4321	349	14	eventually	eventually	ADV
gs-4321	349	15	lead	lead	VERB
gs-4321	349	16	to	to	ADP
gs-4321	349	17	stable	stable	ADJ
gs-4321	349	18	resistance	resistance	NOUN
gs-4321	349	19	phenotypes	phenotype	NOUN
gs-4321	349	20	.	.	PUNCT
gs-4321	350	1	computational	computational	ADJ
gs-4321	350	2	integration	integration	NOUN
gs-4321	350	3	of	of	ADP
gs-4321	350	4	time	time	NOUN
gs-4321	350	5	-	-	PUNCT
gs-4321	350	6	resolved	resolve	VERB
gs-4321	350	7	single	single	ADJ
gs-4321	350	8	-	-	PUNCT
gs-4321	350	9	cell	cell	NOUN
gs-4321	350	10	datasets	dataset	NOUN
gs-4321	350	11	enables	enable	VERB
gs-4321	350	12	reconstruction	reconstruction	NOUN
gs-4321	350	13	of	of	ADP
gs-4321	350	14	these	these	DET
gs-4321	350	15	adaptive	adaptive	ADJ
gs-4321	350	16	trajectories	trajectory	NOUN
gs-4321	350	17	and	and	CCONJ
gs-4321	350	18	identification	identification	NOUN
gs-4321	350	19	of	of	ADP
gs-4321	350	20	regulators	regulator	NOUN
gs-4321	350	21	that	that	PRON
gs-4321	350	22	mediate	mediate	VERB
gs-4321	350	23	early	early	ADJ
gs-4321	350	24	-	-	PUNCT
gs-4321	350	25	phase	phase	NOUN
gs-4321	350	26	reprogramming	reprogramming	NOUN
gs-4321	350	27	.	.	PUNCT
gs-4321	351	1	adaptive	adaptive	ADJ
gs-4321	351	2	stress	stress	NOUN
gs-4321	351	3	programs	program	NOUN
gs-4321	351	4	and	and	CCONJ
gs-4321	351	5	lineage	lineage	NOUN
gs-4321	351	6	plasticity	plasticity	NOUN
gs-4321	351	7	one	one	NUM
gs-4321	351	8	striking	strike	VERB
gs-4321	351	9	feature	feature	NOUN
gs-4321	351	10	of	of	ADP
gs-4321	351	11	therapy	therapy	NOUN
gs-4321	351	12	-	-	PUNCT
gs-4321	351	13	induced	induce	VERB
gs-4321	351	14	adaptability	adaptability	NOUN
gs-4321	351	15	is	be	AUX
gs-4321	351	16	the	the	DET
gs-4321	351	17	frequent	frequent	ADJ
gs-4321	351	18	involvement	involvement	NOUN
gs-4321	351	19	of	of	ADP
gs-4321	351	20	lineage	lineage	NOUN
gs-4321	351	21	plasticity	plasticity	NOUN
gs-4321	351	22	—	—	PUNCT
gs-4321	351	23	where	where	SCONJ
gs-4321	351	24	malignant	malignant	ADJ
gs-4321	351	25	cells	cell	NOUN
gs-4321	351	26	switch	switch	VERB
gs-4321	351	27	between	between	ADP
gs-4321	351	28	differentiation	differentiation	NOUN
gs-4321	351	29	programs	program	NOUN
gs-4321	351	30	to	to	PART
gs-4321	351	31	evade	evade	VERB
gs-4321	351	32	drug	drug	NOUN
gs-4321	351	33	pressure	pressure	NOUN
gs-4321	351	34	.	.	PUNCT
gs-4321	352	1	for	for	ADP
gs-4321	352	2	example	example	NOUN
gs-4321	352	3	,	,	PUNCT
gs-4321	352	4	prostate	prostate	NOUN
gs-4321	352	5	cancer	cancer	NOUN
gs-4321	352	6	cells	cell	NOUN
gs-4321	352	7	undergoing	undergo	VERB
gs-4321	352	8	androgen	androgen	NOUN
gs-4321	352	9	deprivation	deprivation	NOUN
gs-4321	352	10	therapy	therapy	NOUN
gs-4321	352	11	can	can	AUX
gs-4321	352	12	adopt	adopt	VERB
gs-4321	352	13	neuroendocrine	neuroendocrine	NOUN
gs-4321	352	14	-	-	PUNCT
gs-4321	352	15	like	like	ADJ
gs-4321	352	16	characteristics	characteristic	NOUN
gs-4321	352	17	,	,	PUNCT
gs-4321	352	18	while	while	SCONJ
gs-4321	352	19	melanoma	melanoma	NOUN
gs-4321	352	20	cells	cell	NOUN
gs-4321	352	21	exposed	expose	VERB
gs-4321	352	22	to	to	ADP
gs-4321	352	23	mapk	mapk	VERB
gs-4321	352	24	inhibitors	inhibitor	NOUN
gs-4321	352	25	can	can	AUX
gs-4321	352	26	shift	shift	VERB
gs-4321	352	27	into	into	ADP
gs-4321	352	28	neural	neural	ADJ
gs-4321	352	29	crest	crest	NOUN
gs-4321	352	30	–	–	PUNCT
gs-4321	352	31	like	like	ADJ
gs-4321	352	32	or	or	CCONJ
gs-4321	352	33	invasive	invasive	ADJ
gs-4321	352	34	states	state	NOUN
gs-4321	352	35	(	(	PUNCT
gs-4321	352	36	boumahdi	boumahdi	NOUN
gs-4321	352	37	and	and	CCONJ
gs-4321	352	38	de	de	X
gs-4321	352	39	sauvage	sauvage	PROPN
gs-4321	352	40	,	,	PUNCT
gs-4321	352	41	2020	2020	NUM
gs-4321	352	42	;	;	PUNCT
gs-4321	352	43	rambow	rambow	PROPN
gs-4321	352	44	et	et	PROPN
gs-4321	352	45	al	al	PROPN
gs-4321	352	46	.	.	PROPN
gs-4321	352	47	,	,	PUNCT
gs-4321	352	48	2018	2018	NUM
gs-4321	352	49	)	)	PUNCT
gs-4321	352	50	.	.	PUNCT
gs-4321	353	1	these	these	DET
gs-4321	353	2	lineage	lineage	NOUN
gs-4321	353	3	switches	switch	NOUN
gs-4321	353	4	are	be	AUX
gs-4321	353	5	orchestrated	orchestrate	VERB
gs-4321	353	6	by	by	ADP
gs-4321	353	7	transcription	transcription	NOUN
gs-4321	353	8	factors	factor	NOUN
gs-4321	353	9	georgian	georgian	NOUN
gs-4321	353	10	scientists/	scientists/	NUM
gs-4321	353	11	.	.	PUNCT
gs-4321	354	1	7	7	NUM
gs-4321	354	2	n	n	DET
gs-4321	354	3	4	4	NUM
gs-4321	354	4	,	,	PUNCT
gs-4321	354	5	2025	2025	NUM
gs-4321	354	6	355	355	NUM
gs-4321	354	7	such	such	ADJ
gs-4321	354	8	as	as	ADP
gs-4321	354	9	sox2	sox2	NOUN
gs-4321	354	10	,	,	PUNCT
gs-4321	354	11	brn2	brn2	NOUN
gs-4321	354	12	,	,	PUNCT
gs-4321	354	13	and	and	CCONJ
gs-4321	354	14	nfatc2	nfatc2	NOUN
gs-4321	354	15	and	and	CCONJ
gs-4321	354	16	are	be	AUX
gs-4321	354	17	facilitated	facilitate	VERB
gs-4321	354	18	by	by	ADP
gs-4321	354	19	epigenetic	epigenetic	ADJ
gs-4321	354	20	remodeling	remodeling	NOUN
gs-4321	354	21	that	that	PRON
gs-4321	354	22	opens	open	VERB
gs-4321	354	23	chromatin	chromatin	NOUN
gs-4321	354	24	regions	region	NOUN
gs-4321	354	25	associated	associate	VERB
gs-4321	354	26	with	with	ADP
gs-4321	354	27	alternative	alternative	ADJ
gs-4321	354	28	fates	fate	NOUN
gs-4321	354	29	.	.	PUNCT
gs-4321	355	1	single	single	ADJ
gs-4321	355	2	-	-	PUNCT
gs-4321	355	3	cell	cell	NOUN
gs-4321	355	4	bioinformatic	bioinformatic	ADJ
gs-4321	355	5	tools	tool	NOUN
gs-4321	355	6	such	such	ADJ
gs-4321	355	7	as	as	ADP
gs-4321	355	8	master	master	NOUN
gs-4321	355	9	regulator	regulator	NOUN
gs-4321	355	10	analysis	analysis	NOUN
gs-4321	355	11	,	,	PUNCT
gs-4321	355	12	scenic	scenic	ADJ
gs-4321	355	13	,	,	PUNCT
gs-4321	355	14	and	and	CCONJ
gs-4321	355	15	grnboost	grnboost	NOUN
gs-4321	355	16	can	can	AUX
gs-4321	355	17	identify	identify	VERB
gs-4321	355	18	transcriptional	transcriptional	ADJ
gs-4321	355	19	control	control	NOUN
gs-4321	355	20	nodes	node	NOUN
gs-4321	355	21	that	that	PRON
gs-4321	355	22	drive	drive	VERB
gs-4321	355	23	lineage	lineage	NOUN
gs-4321	355	24	divergence	divergence	NOUN
gs-4321	355	25	under	under	ADP
gs-4321	355	26	therapy	therapy	NOUN
gs-4321	355	27	pressure	pressure	NOUN
gs-4321	355	28	(	(	PUNCT
gs-4321	355	29	aibar	aibar	NOUN
gs-4321	355	30	et	et	PROPN
gs-4321	355	31	al	al	PROPN
gs-4321	355	32	.	.	PROPN
gs-4321	355	33	,	,	PUNCT
gs-4321	355	34	2017	2017	NUM
gs-4321	355	35	)	)	PUNCT
gs-4321	355	36	.	.	PUNCT
gs-4321	356	1	when	when	SCONJ
gs-4321	356	2	combined	combine	VERB
gs-4321	356	3	with	with	ADP
gs-4321	356	4	epigenomic	epigenomic	ADJ
gs-4321	356	5	assays	assay	NOUN
gs-4321	356	6	like	like	ADP
gs-4321	356	7	atac	atac	NOUN
gs-4321	356	8	-	-	PUNCT
gs-4321	356	9	seq	seq	NOUN
gs-4321	356	10	,	,	PUNCT
gs-4321	356	11	these	these	DET
gs-4321	356	12	tools	tool	NOUN
gs-4321	356	13	reveal	reveal	VERB
gs-4321	356	14	how	how	SCONJ
gs-4321	356	15	lineage	lineage	NOUN
gs-4321	356	16	-	-	PUNCT
gs-4321	356	17	specifying	specify	VERB
gs-4321	356	18	factors	factor	NOUN
gs-4321	356	19	reshape	reshape	VERB
gs-4321	356	20	chromatin	chromatin	NOUN
gs-4321	356	21	to	to	ADP
gs-4321	356	22	unlock	unlock	VERB
gs-4321	356	23	alternative	alternative	ADJ
gs-4321	356	24	identities	identity	NOUN
gs-4321	356	25	.	.	PUNCT
gs-4321	357	1	this	this	DET
gs-4321	357	2	integrative	integrative	ADJ
gs-4321	357	3	approach	approach	NOUN
gs-4321	357	4	is	be	AUX
gs-4321	357	5	crucial	crucial	ADJ
gs-4321	357	6	for	for	ADP
gs-4321	357	7	determining	determine	VERB
gs-4321	357	8	whether	whether	SCONJ
gs-4321	357	9	lineage	lineage	NOUN
gs-4321	357	10	plasticity	plasticity	NOUN
gs-4321	357	11	represents	represent	VERB
gs-4321	357	12	a	a	DET
gs-4321	357	13	preexisting	preexist	VERB
gs-4321	357	14	potential	potential	NOUN
gs-4321	357	15	within	within	ADP
gs-4321	357	16	malignant	malignant	ADJ
gs-4321	357	17	cells	cell	NOUN
gs-4321	357	18	or	or	CCONJ
gs-4321	357	19	emerges	emerge	VERB
gs-4321	357	20	de	de	X
gs-4321	357	21	novo	novo	NOUN
gs-4321	357	22	in	in	ADP
gs-4321	357	23	response	response	NOUN
gs-4321	357	24	to	to	ADP
gs-4321	357	25	therapy	therapy	NOUN
gs-4321	357	26	.	.	PUNCT
gs-4321	358	1	niche	niche	NOUN
gs-4321	358	2	-	-	PUNCT
gs-4321	358	3	mediated	mediate	VERB
gs-4321	358	4	resistance	resistance	NOUN
gs-4321	358	5	and	and	CCONJ
gs-4321	358	6	microenvironmental	microenvironmental	ADJ
gs-4321	358	7	support	support	NOUN
gs-4321	358	8	the	the	DET
gs-4321	358	9	microenvironment	microenvironment	NOUN
gs-4321	358	10	often	often	ADV
gs-4321	358	11	reinforces	reinforce	VERB
gs-4321	358	12	therapy	therapy	NOUN
gs-4321	358	13	-	-	PUNCT
gs-4321	358	14	induced	induce	VERB
gs-4321	358	15	plasticity	plasticity	NOUN
gs-4321	358	16	by	by	ADP
gs-4321	358	17	providing	provide	VERB
gs-4321	358	18	survival	survival	NOUN
gs-4321	358	19	cues	cue	NOUN
gs-4321	358	20	through	through	ADP
gs-4321	358	21	cytokines	cytokine	NOUN
gs-4321	358	22	,	,	PUNCT
gs-4321	358	23	metabolic	metabolic	NOUN
gs-4321	358	24	support	support	NOUN
gs-4321	358	25	,	,	PUNCT
gs-4321	358	26	or	or	CCONJ
gs-4321	358	27	extracellular	extracellular	ADJ
gs-4321	358	28	matrix	matrix	NOUN
gs-4321	358	29	remodeling	remodeling	NOUN
gs-4321	358	30	.	.	PUNCT
gs-4321	359	1	cafderived	cafderived	PROPN
gs-4321	359	2	tgf	tgf	PROPN
gs-4321	359	3	and	and	CCONJ
gs-4321	359	4	il-6	il-6	NOUN
gs-4321	359	5	signaling	signal	VERB
gs-4321	359	6	,	,	PUNCT
gs-4321	359	7	macrophage	macrophage	ADJ
gs-4321	359	8	-	-	PUNCT
gs-4321	359	9	mediated	mediate	VERB
gs-4321	359	10	stat3	stat3	NOUN
gs-4321	359	11	activation	activation	NOUN
gs-4321	359	12	,	,	PUNCT
gs-4321	359	13	and	and	CCONJ
gs-4321	359	14	immunesuppressed	immunesuppressed	ADJ
gs-4321	359	15	niches	niche	NOUN
gs-4321	359	16	enriched	enrich	VERB
gs-4321	359	17	for	for	ADP
gs-4321	359	18	regulatory	regulatory	ADJ
gs-4321	359	19	t	t	NOUN
gs-4321	359	20	cells	cell	NOUN
gs-4321	359	21	can	can	AUX
gs-4321	359	22	all	all	PRON
gs-4321	359	23	support	support	VERB
gs-4321	359	24	transitions	transition	NOUN
gs-4321	359	25	into	into	ADP
gs-4321	359	26	adaptive	adaptive	ADJ
gs-4321	359	27	states	state	NOUN
gs-4321	359	28	(	(	PUNCT
gs-4321	359	29	cassetta	cassetta	NOUN
gs-4321	359	30	and	and	CCONJ
gs-4321	359	31	pollard	pollard	NOUN
gs-4321	359	32	,	,	PUNCT
gs-4321	359	33	2020	2020	NUM
gs-4321	359	34	;	;	PUNCT
gs-4321	359	35	glodde	glodde	VERB
gs-4321	359	36	et	et	PROPN
gs-4321	359	37	al	al	PROPN
gs-4321	359	38	.	.	PROPN
gs-4321	359	39	,	,	PUNCT
gs-4321	359	40	2017	2017	NUM
gs-4321	359	41	)	)	PUNCT
gs-4321	359	42	.	.	PUNCT
gs-4321	360	1	spatial	spatial	ADJ
gs-4321	360	2	transcriptomic	transcriptomic	ADJ
gs-4321	360	3	and	and	CCONJ
gs-4321	360	4	communication	communication	NOUN
gs-4321	360	5	-	-	PUNCT
gs-4321	360	6	inference	inference	NOUN
gs-4321	360	7	analyses	analysis	NOUN
gs-4321	360	8	allow	allow	VERB
gs-4321	360	9	precise	precise	ADJ
gs-4321	360	10	mapping	mapping	NOUN
gs-4321	360	11	of	of	ADP
gs-4321	360	12	these	these	DET
gs-4321	360	13	niche	niche	NOUN
gs-4321	360	14	-	-	PUNCT
gs-4321	360	15	specific	specific	ADJ
gs-4321	360	16	influences	influence	NOUN
gs-4321	360	17	,	,	PUNCT
gs-4321	360	18	revealing	reveal	VERB
gs-4321	360	19	microdomains	microdomain	NOUN
gs-4321	360	20	where	where	SCONJ
gs-4321	360	21	resistant	resistant	ADJ
gs-4321	360	22	phenotypes	phenotype	NOUN
gs-4321	360	23	are	be	AUX
gs-4321	360	24	most	most	ADV
gs-4321	360	25	likely	likely	ADJ
gs-4321	360	26	to	to	PART
gs-4321	360	27	emerge	emerge	VERB
gs-4321	360	28	.	.	PUNCT
gs-4321	361	1	understanding	understand	VERB
gs-4321	361	2	these	these	DET
gs-4321	361	3	spatially	spatially	ADV
gs-4321	361	4	constrained	constrain	VERB
gs-4321	361	5	interactions	interaction	NOUN
gs-4321	361	6	is	be	AUX
gs-4321	361	7	essential	essential	ADJ
gs-4321	361	8	,	,	PUNCT
gs-4321	361	9	as	as	SCONJ
gs-4321	361	10	therapeutic	therapeutic	ADJ
gs-4321	361	11	targeting	targeting	NOUN
gs-4321	361	12	of	of	ADP
gs-4321	361	13	adaptive	adaptive	ADJ
gs-4321	361	14	states	state	NOUN
gs-4321	361	15	will	will	AUX
gs-4321	361	16	require	require	VERB
gs-4321	361	17	interventions	intervention	NOUN
gs-4321	361	18	that	that	PRON
gs-4321	361	19	disrupt	disrupt	VERB
gs-4321	361	20	both	both	PRON
gs-4321	361	21	intrinsic	intrinsic	ADJ
gs-4321	361	22	regulatory	regulatory	ADJ
gs-4321	361	23	networks	network	NOUN
gs-4321	361	24	and	and	CCONJ
gs-4321	361	25	extrinsic	extrinsic	ADJ
gs-4321	361	26	niche	niche	NOUN
gs-4321	361	27	-	-	PUNCT
gs-4321	361	28	derived	derive	VERB
gs-4321	361	29	signals	signal	NOUN
gs-4321	361	30	.	.	PUNCT
gs-4321	362	1	opportunities	opportunity	NOUN
gs-4321	362	2	for	for	ADP
gs-4321	362	3	targeting	target	VERB
gs-4321	362	4	plasticity	plasticity	NOUN
gs-4321	362	5	as	as	ADP
gs-4321	362	6	the	the	DET
gs-4321	362	7	mechanisms	mechanism	NOUN
gs-4321	362	8	underlying	underlie	VERB
gs-4321	362	9	therapy	therapy	NOUN
gs-4321	362	10	-	-	PUNCT
gs-4321	362	11	induced	induced	ADJ
gs-4321	362	12	reprogramming	reprogramming	NOUN
gs-4321	362	13	become	become	VERB
gs-4321	362	14	clearer	clear	ADJ
gs-4321	362	15	,	,	PUNCT
gs-4321	362	16	new	new	ADJ
gs-4321	362	17	therapeutic	therapeutic	ADJ
gs-4321	362	18	strategies	strategy	NOUN
gs-4321	362	19	are	be	AUX
gs-4321	362	20	emerging	emerge	VERB
gs-4321	362	21	.	.	PUNCT
gs-4321	363	1	targeting	target	VERB
gs-4321	363	2	epigenetic	epigenetic	ADJ
gs-4321	363	3	regulators	regulator	NOUN
gs-4321	363	4	,	,	PUNCT
gs-4321	363	5	inhibiting	inhibit	VERB
gs-4321	363	6	key	key	ADJ
gs-4321	363	7	transcriptional	transcriptional	NOUN
gs-4321	363	8	modules	module	NOUN
gs-4321	363	9	,	,	PUNCT
gs-4321	363	10	modulating	modulate	VERB
gs-4321	363	11	metabolic	metabolic	NOUN
gs-4321	363	12	dependencies	dependency	NOUN
gs-4321	363	13	,	,	PUNCT
gs-4321	363	14	or	or	CCONJ
gs-4321	363	15	blocking	block	VERB
gs-4321	363	16	microenvironmental	microenvironmental	ADJ
gs-4321	363	17	communication	communication	NOUN
gs-4321	363	18	channels	channel	NOUN
gs-4321	363	19	offers	offer	VERB
gs-4321	363	20	potential	potential	ADJ
gs-4321	363	21	routes	route	NOUN
gs-4321	363	22	to	to	ADP
gs-4321	363	23	preventing	prevent	VERB
gs-4321	363	24	or	or	CCONJ
gs-4321	363	25	reversing	reverse	VERB
gs-4321	363	26	adaptive	adaptive	ADJ
gs-4321	363	27	state	state	NOUN
gs-4321	363	28	transitions	transition	NOUN
gs-4321	363	29	.	.	PUNCT
gs-4321	364	1	bioinformatic	bioinformatic	ADJ
gs-4321	364	2	frameworks	framework	NOUN
gs-4321	364	3	capable	capable	ADJ
gs-4321	364	4	of	of	ADP
gs-4321	364	5	predicting	predict	VERB
gs-4321	364	6	these	these	DET
gs-4321	364	7	transitions	transition	NOUN
gs-4321	364	8	provide	provide	VERB
gs-4321	364	9	a	a	DET
gs-4321	364	10	rational	rational	ADJ
gs-4321	364	11	foundation	foundation	NOUN
gs-4321	364	12	for	for	ADP
gs-4321	364	13	selecting	select	VERB
gs-4321	364	14	combination	combination	NOUN
gs-4321	364	15	therapies	therapy	NOUN
gs-4321	364	16	designed	design	VERB
gs-4321	364	17	to	to	PART
gs-4321	364	18	eliminate	eliminate	VERB
gs-4321	364	19	both	both	DET
gs-4321	364	20	bulk	bulk	ADJ
gs-4321	364	21	tumor	tumor	NOUN
gs-4321	364	22	populations	population	NOUN
gs-4321	364	23	and	and	CCONJ
gs-4321	364	24	their	their	PRON
gs-4321	364	25	adaptive	adaptive	ADJ
gs-4321	364	26	derivatives	derivative	NOUN
gs-4321	364	27	.	.	PUNCT
gs-4321	365	1	computational	computational	ADJ
gs-4321	365	2	frameworks	framework	NOUN
gs-4321	365	3	for	for	ADP
gs-4321	365	4	integrating	integrate	VERB
gs-4321	365	5	regulatory	regulatory	ADJ
gs-4321	365	6	and	and	CCONJ
gs-4321	365	7	ecological	ecological	ADJ
gs-4321	365	8	determinants	determinant	NOUN
gs-4321	365	9	a	a	DET
gs-4321	365	10	major	major	ADJ
gs-4321	365	11	frontier	frontier	NOUN
gs-4321	365	12	in	in	ADP
gs-4321	365	13	understanding	understand	VERB
gs-4321	365	14	adaptive	adaptive	ADJ
gs-4321	365	15	behavior	behavior	NOUN
gs-4321	365	16	lies	lie	VERB
gs-4321	365	17	in	in	ADP
gs-4321	365	18	developing	develop	VERB
gs-4321	365	19	computational	computational	ADJ
gs-4321	365	20	approaches	approach	NOUN
gs-4321	365	21	capable	capable	ADJ
gs-4321	365	22	of	of	ADP
gs-4321	365	23	synthesizing	synthesize	VERB
gs-4321	365	24	regulatory	regulatory	ADJ
gs-4321	365	25	,	,	PUNCT
gs-4321	365	26	ecological	ecological	ADJ
gs-4321	365	27	,	,	PUNCT
gs-4321	365	28	genetic	genetic	ADJ
gs-4321	365	29	,	,	PUNCT
gs-4321	365	30	and	and	CCONJ
gs-4321	365	31	spatial	spatial	ADJ
gs-4321	365	32	information	information	NOUN
gs-4321	365	33	into	into	ADP
gs-4321	365	34	unified	unified	ADJ
gs-4321	365	35	models	model	NOUN
gs-4321	365	36	.	.	PUNCT
gs-4321	366	1	tumors	tumor	NOUN
gs-4321	366	2	do	do	AUX
gs-4321	366	3	not	not	PART
gs-4321	366	4	operate	operate	VERB
gs-4321	366	5	through	through	ADP
gs-4321	366	6	isolated	isolate	VERB
gs-4321	366	7	molecular	molecular	ADJ
gs-4321	366	8	mechanisms	mechanism	NOUN
gs-4321	366	9	;	;	PUNCT
gs-4321	366	10	instead	instead	ADV
gs-4321	366	11	,	,	PUNCT
gs-4321	366	12	adaptive	adaptive	ADJ
gs-4321	366	13	phenotypes	phenotype	NOUN
gs-4321	366	14	arise	arise	VERB
gs-4321	366	15	from	from	ADP
gs-4321	366	16	the	the	DET
gs-4321	366	17	interaction	interaction	NOUN
gs-4321	366	18	of	of	ADP
gs-4321	366	19	intracellular	intracellular	ADJ
gs-4321	366	20	regulatory	regulatory	ADJ
gs-4321	366	21	networks	network	NOUN
gs-4321	366	22	with	with	ADP
gs-4321	366	23	external	external	ADJ
gs-4321	366	24	microenvironmental	microenvironmental	ADJ
gs-4321	366	25	pressures	pressure	NOUN
gs-4321	366	26	and	and	CCONJ
gs-4321	366	27	evolutionary	evolutionary	ADJ
gs-4321	366	28	constraints	constraint	NOUN
gs-4321	366	29	.	.	PUNCT
gs-4321	367	1	single	single	ADJ
gs-4321	367	2	-	-	PUNCT
gs-4321	367	3	cell	cell	NOUN
gs-4321	367	4	bioinformatics	bioinformatics	NOUN
gs-4321	367	5	offers	offer	VERB
gs-4321	367	6	the	the	DET
gs-4321	367	7	analytical	analytical	ADJ
gs-4321	367	8	foundation	foundation	NOUN
gs-4321	367	9	necessary	necessary	ADJ
gs-4321	367	10	to	to	PART
gs-4321	367	11	model	model	VERB
gs-4321	367	12	these	these	DET
gs-4321	367	13	multiscale	multiscale	ADJ
gs-4321	367	14	interactions	interaction	NOUN
gs-4321	367	15	,	,	PUNCT
gs-4321	367	16	enabling	enable	VERB
gs-4321	367	17	researchers	researcher	NOUN
gs-4321	367	18	to	to	PART
gs-4321	367	19	understand	understand	VERB
gs-4321	367	20	how	how	SCONJ
gs-4321	367	21	cellular	cellular	ADJ
gs-4321	367	22	behavior	behavior	NOUN
gs-4321	367	23	emerges	emerge	VERB
gs-4321	367	24	from	from	ADP
gs-4321	367	25	both	both	CCONJ
gs-4321	367	26	autonomous	autonomous	ADJ
gs-4321	367	27	and	and	CCONJ
gs-4321	367	28	non	non	ADJ
gs-4321	367	29	-	-	ADJ
gs-4321	367	30	autonomous	autonomous	ADJ
gs-4321	367	31	influences	influence	NOUN
gs-4321	367	32	.	.	PUNCT
gs-4321	368	1	georgian	georgian	NOUN
gs-4321	368	2	scientists/	scientists/	NUM
gs-4321	368	3	.	.	PUNCT
gs-4321	369	1	7	7	NUM
gs-4321	369	2	n	n	DET
gs-4321	369	3	4	4	NUM
gs-4321	369	4	,	,	PUNCT
gs-4321	369	5	2025	2025	NUM
gs-4321	369	6	356	356	NUM
gs-4321	369	7	graph	graph	NOUN
gs-4321	369	8	-	-	PUNCT
gs-4321	369	9	based	base	VERB
gs-4321	369	10	frameworks	framework	NOUN
gs-4321	369	11	such	such	ADJ
gs-4321	369	12	as	as	ADP
gs-4321	369	13	paga	paga	NOUN
gs-4321	369	14	,	,	PUNCT
gs-4321	369	15	stagate	stagate	NOUN
gs-4321	369	16	,	,	PUNCT
gs-4321	369	17	and	and	CCONJ
gs-4321	369	18	celltree	celltree	NOUN
gs-4321	369	19	facilitate	facilitate	NOUN
gs-4321	369	20	analysis	analysis	NOUN
gs-4321	369	21	of	of	ADP
gs-4321	369	22	cellular	cellular	ADJ
gs-4321	369	23	relationships	relationship	NOUN
gs-4321	369	24	and	and	CCONJ
gs-4321	369	25	topological	topological	ADJ
gs-4321	369	26	structures	structure	NOUN
gs-4321	369	27	across	across	ADP
gs-4321	369	28	heterogeneous	heterogeneous	ADJ
gs-4321	369	29	populations	population	NOUN
gs-4321	369	30	(	(	PUNCT
gs-4321	369	31	wolf	wolf	PROPN
gs-4321	369	32	et	et	PROPN
gs-4321	369	33	al	al	PROPN
gs-4321	369	34	.	.	PROPN
gs-4321	369	35	,	,	PUNCT
gs-4321	369	36	2019	2019	NUM
gs-4321	369	37	;	;	PUNCT
gs-4321	369	38	dong	dong	PROPN
gs-4321	369	39	and	and	CCONJ
gs-4321	369	40	zhang	zhang	PROPN
gs-4321	369	41	,	,	PUNCT
gs-4321	369	42	2022	2022	NUM
gs-4321	369	43	)	)	PUNCT
gs-4321	369	44	.	.	PUNCT
gs-4321	370	1	by	by	ADP
gs-4321	370	2	representing	represent	VERB
gs-4321	370	3	cell	cell	NOUN
gs-4321	370	4	states	state	NOUN
gs-4321	370	5	as	as	ADP
gs-4321	370	6	nodes	node	NOUN
gs-4321	370	7	within	within	ADP
gs-4321	370	8	a	a	DET
gs-4321	370	9	graph	graph	NOUN
gs-4321	370	10	,	,	PUNCT
gs-4321	370	11	and	and	CCONJ
gs-4321	370	12	transitions	transition	NOUN
gs-4321	370	13	or	or	CCONJ
gs-4321	370	14	similarities	similarity	NOUN
gs-4321	370	15	as	as	ADP
gs-4321	370	16	edges	edge	NOUN
gs-4321	370	17	,	,	PUNCT
gs-4321	370	18	these	these	DET
gs-4321	370	19	models	model	NOUN
gs-4321	370	20	provide	provide	VERB
gs-4321	370	21	an	an	DET
gs-4321	370	22	intuitive	intuitive	ADJ
gs-4321	370	23	representation	representation	NOUN
gs-4321	370	24	of	of	ADP
gs-4321	370	25	how	how	SCONJ
gs-4321	370	26	malignant	malignant	ADJ
gs-4321	370	27	populations	population	NOUN
gs-4321	370	28	reorganize	reorganize	VERB
gs-4321	370	29	in	in	ADP
gs-4321	370	30	response	response	NOUN
gs-4321	370	31	to	to	ADP
gs-4321	370	32	environmental	environmental	ADJ
gs-4321	370	33	changes	change	NOUN
gs-4321	370	34	or	or	CCONJ
gs-4321	370	35	therapeutic	therapeutic	ADJ
gs-4321	370	36	challenges	challenge	NOUN
gs-4321	370	37	.	.	PUNCT
gs-4321	371	1	integrating	integrate	VERB
gs-4321	371	2	regulatory	regulatory	ADJ
gs-4321	371	3	information	information	NOUN
gs-4321	371	4	—	—	PUNCT
gs-4321	371	5	such	such	ADJ
gs-4321	371	6	as	as	ADP
gs-4321	371	7	transcription	transcription	NOUN
gs-4321	371	8	factor	factor	NOUN
gs-4321	371	9	activity	activity	NOUN
gs-4321	371	10	or	or	CCONJ
gs-4321	371	11	chromatin	chromatin	NOUN
gs-4321	371	12	accessibility	accessibility	NOUN
gs-4321	371	13	—	—	PUNCT
gs-4321	371	14	onto	onto	ADP
gs-4321	371	15	these	these	DET
gs-4321	371	16	graphs	graph	NOUN
gs-4321	371	17	allows	allow	VERB
gs-4321	371	18	identification	identification	NOUN
gs-4321	371	19	of	of	ADP
gs-4321	371	20	key	key	ADJ
gs-4321	371	21	control	control	NOUN
gs-4321	371	22	points	point	NOUN
gs-4321	371	23	within	within	ADP
gs-4321	371	24	the	the	DET
gs-4321	371	25	adaptive	adaptive	ADJ
gs-4321	371	26	architecture	architecture	NOUN
gs-4321	371	27	.	.	PUNCT
gs-4321	372	1	modeling	model	VERB
gs-4321	372	2	state	state	NOUN
gs-4321	372	3	transitions	transition	NOUN
gs-4321	372	4	using	use	VERB
gs-4321	372	5	dynamical	dynamical	ADJ
gs-4321	372	6	systems	system	NOUN
gs-4321	372	7	dynamical	dynamical	ADJ
gs-4321	372	8	systems	system	NOUN
gs-4321	372	9	modeling	modeling	NOUN
gs-4321	372	10	represents	represent	VERB
gs-4321	372	11	another	another	DET
gs-4321	372	12	powerful	powerful	ADJ
gs-4321	372	13	approach	approach	NOUN
gs-4321	372	14	for	for	ADP
gs-4321	372	15	dissecting	dissect	VERB
gs-4321	372	16	the	the	DET
gs-4321	372	17	logic	logic	NOUN
gs-4321	372	18	of	of	ADP
gs-4321	372	19	phenotypic	phenotypic	ADJ
gs-4321	372	20	transitions	transition	NOUN
gs-4321	372	21	.	.	PUNCT
gs-4321	373	1	ordinary	ordinary	ADJ
gs-4321	373	2	differential	differential	ADJ
gs-4321	373	3	equation	equation	NOUN
gs-4321	373	4	models	model	NOUN
gs-4321	373	5	,	,	PUNCT
gs-4321	373	6	boolean	boolean	ADJ
gs-4321	373	7	networks	network	NOUN
gs-4321	373	8	,	,	PUNCT
gs-4321	373	9	and	and	CCONJ
gs-4321	373	10	stochastic	stochastic	ADJ
gs-4321	373	11	simulations	simulation	NOUN
gs-4321	373	12	can	can	AUX
gs-4321	373	13	capture	capture	VERB
gs-4321	373	14	the	the	DET
gs-4321	373	15	temporal	temporal	ADJ
gs-4321	373	16	evolution	evolution	NOUN
gs-4321	373	17	of	of	ADP
gs-4321	373	18	regulatory	regulatory	ADJ
gs-4321	373	19	networks	network	NOUN
gs-4321	373	20	controlling	control	VERB
gs-4321	373	21	cellular	cellular	ADJ
gs-4321	373	22	identity	identity	NOUN
gs-4321	373	23	.	.	PUNCT
gs-4321	374	1	when	when	SCONJ
gs-4321	374	2	such	such	ADJ
gs-4321	374	3	models	model	NOUN
gs-4321	374	4	are	be	AUX
gs-4321	374	5	informed	inform	VERB
gs-4321	374	6	by	by	ADP
gs-4321	374	7	single	single	ADJ
gs-4321	374	8	-	-	PUNCT
gs-4321	374	9	cell	cell	NOUN
gs-4321	374	10	datasets	dataset	NOUN
gs-4321	374	11	,	,	PUNCT
gs-4321	374	12	they	they	PRON
gs-4321	374	13	become	become	VERB
gs-4321	374	14	capable	capable	ADJ
gs-4321	374	15	of	of	ADP
gs-4321	374	16	predicting	predict	VERB
gs-4321	374	17	not	not	PART
gs-4321	374	18	only	only	ADV
gs-4321	374	19	how	how	SCONJ
gs-4321	374	20	states	state	NOUN
gs-4321	374	21	evolve	evolve	VERB
gs-4321	374	22	but	but	CCONJ
gs-4321	374	23	also	also	ADV
gs-4321	374	24	how	how	SCONJ
gs-4321	374	25	perturbations	perturbation	NOUN
gs-4321	374	26	may	may	AUX
gs-4321	374	27	redirect	redirect	VERB
gs-4321	374	28	trajectories	trajectory	NOUN
gs-4321	374	29	(	(	PUNCT
gs-4321	374	30	qiu	qiu	PROPN
gs-4321	374	31	et	et	PROPN
gs-4321	374	32	al	al	PROPN
gs-4321	374	33	.	.	PROPN
gs-4321	374	34	,	,	PUNCT
gs-4321	374	35	2022	2022	NUM
gs-4321	374	36	)	)	PUNCT
gs-4321	374	37	.	.	PUNCT
gs-4321	375	1	these	these	DET
gs-4321	375	2	computational	computational	ADJ
gs-4321	375	3	strategies	strategy	NOUN
gs-4321	375	4	have	have	AUX
gs-4321	375	5	been	be	AUX
gs-4321	375	6	applied	apply	VERB
gs-4321	375	7	to	to	PART
gs-4321	375	8	identify	identify	VERB
gs-4321	375	9	regulatory	regulatory	ADJ
gs-4321	375	10	motifs	motif	NOUN
gs-4321	375	11	—	—	PUNCT
gs-4321	375	12	such	such	ADJ
gs-4321	375	13	as	as	ADP
gs-4321	375	14	bistable	bistable	ADJ
gs-4321	375	15	switches	switch	NOUN
gs-4321	375	16	or	or	CCONJ
gs-4321	375	17	multistable	multistable	ADJ
gs-4321	375	18	circuits	circuit	NOUN
gs-4321	375	19	—	—	PUNCT
gs-4321	375	20	that	that	PRON
gs-4321	375	21	create	create	VERB
gs-4321	375	22	the	the	DET
gs-4321	375	23	potential	potential	NOUN
gs-4321	375	24	for	for	ADP
gs-4321	375	25	reversible	reversible	ADJ
gs-4321	375	26	state	state	NOUN
gs-4321	375	27	transitions	transition	NOUN
gs-4321	375	28	,	,	PUNCT
gs-4321	375	29	a	a	DET
gs-4321	375	30	hallmark	hallmark	NOUN
gs-4321	375	31	of	of	ADP
gs-4321	375	32	adaptive	adaptive	ADJ
gs-4321	375	33	malignant	malignant	ADJ
gs-4321	375	34	behavior	behavior	NOUN
gs-4321	375	35	.	.	PUNCT
gs-4321	376	1	in	in	ADP
gs-4321	376	2	cancers	cancer	NOUN
gs-4321	376	3	,	,	PUNCT
gs-4321	376	4	modeling	model	VERB
gs-4321	376	5	efforts	effort	NOUN
gs-4321	376	6	have	have	AUX
gs-4321	376	7	revealed	reveal	VERB
gs-4321	376	8	that	that	SCONJ
gs-4321	376	9	regulatory	regulatory	ADJ
gs-4321	376	10	networks	network	NOUN
gs-4321	376	11	associated	associate	VERB
gs-4321	376	12	with	with	ADP
gs-4321	376	13	stemlike	stemlike	ADJ
gs-4321	376	14	states	state	NOUN
gs-4321	376	15	frequently	frequently	ADV
gs-4321	376	16	exhibit	exhibit	VERB
gs-4321	376	17	multistability	multistability	NOUN
gs-4321	376	18	,	,	PUNCT
gs-4321	376	19	enabling	enable	VERB
gs-4321	376	20	cells	cell	NOUN
gs-4321	376	21	to	to	ADP
gs-4321	376	22	transition	transition	NOUN
gs-4321	376	23	between	between	ADP
gs-4321	376	24	multiple	multiple	ADJ
gs-4321	376	25	metastable	metastable	ADJ
gs-4321	376	26	phenotypes	phenotype	NOUN
gs-4321	376	27	depending	depend	VERB
gs-4321	376	28	on	on	ADP
gs-4321	376	29	external	external	ADJ
gs-4321	376	30	signaling	signaling	ADJ
gs-4321	376	31	or	or	CCONJ
gs-4321	376	32	stress	stress	NOUN
gs-4321	376	33	conditions	condition	NOUN
gs-4321	376	34	.	.	PUNCT
gs-4321	377	1	these	these	DET
gs-4321	377	2	insights	insight	NOUN
gs-4321	377	3	help	help	VERB
gs-4321	377	4	explain	explain	VERB
gs-4321	377	5	why	why	SCONJ
gs-4321	377	6	therapeutic	therapeutic	ADJ
gs-4321	377	7	targeting	targeting	NOUN
gs-4321	377	8	of	of	ADP
gs-4321	377	9	single	single	ADJ
gs-4321	377	10	pathways	pathway	NOUN
gs-4321	377	11	often	often	ADV
gs-4321	377	12	fails	fail	VERB
gs-4321	377	13	:	:	PUNCT
gs-4321	377	14	the	the	DET
gs-4321	377	15	underlying	underlie	VERB
gs-4321	377	16	network	network	NOUN
gs-4321	377	17	architecture	architecture	NOUN
gs-4321	377	18	provides	provide	VERB
gs-4321	377	19	alternative	alternative	ADJ
gs-4321	377	20	routes	route	NOUN
gs-4321	377	21	to	to	ADP
gs-4321	377	22	resistance	resistance	NOUN
gs-4321	377	23	.	.	PUNCT
gs-4321	378	1	machine	machine	NOUN
gs-4321	378	2	learning	learn	VERB
gs-4321	378	3	for	for	ADP
gs-4321	378	4	predictive	predictive	ADJ
gs-4321	378	5	oncology	oncology	NOUN
gs-4321	378	6	machine	machine	NOUN
gs-4321	378	7	-	-	PUNCT
gs-4321	378	8	learning	learn	VERB
gs-4321	378	9	approaches	approach	NOUN
gs-4321	378	10	are	be	AUX
gs-4321	378	11	increasingly	increasingly	ADV
gs-4321	378	12	used	use	VERB
gs-4321	378	13	to	to	PART
gs-4321	378	14	infer	infer	VERB
gs-4321	378	15	regulatory	regulatory	ADJ
gs-4321	378	16	determinants	determinant	NOUN
gs-4321	378	17	,	,	PUNCT
gs-4321	378	18	predict	predict	VERB
gs-4321	378	19	cell	cell	NOUN
gs-4321	378	20	fate	fate	NOUN
gs-4321	378	21	,	,	PUNCT
gs-4321	378	22	and	and	CCONJ
gs-4321	378	23	classify	classify	VERB
gs-4321	378	24	intermediate	intermediate	ADJ
gs-4321	378	25	states	state	NOUN
gs-4321	378	26	that	that	SCONJ
gs-4321	378	27	traditional	traditional	ADJ
gs-4321	378	28	clustering	clustering	ADJ
gs-4321	378	29	methods	method	NOUN
gs-4321	378	30	fail	fail	VERB
gs-4321	378	31	to	to	PART
gs-4321	378	32	resolve	resolve	VERB
gs-4321	378	33	.	.	PUNCT
gs-4321	379	1	models	model	NOUN
gs-4321	379	2	based	base	VERB
gs-4321	379	3	on	on	ADP
gs-4321	379	4	random	random	ADJ
gs-4321	379	5	forests	forest	NOUN
gs-4321	379	6	,	,	PUNCT
gs-4321	379	7	support	support	VERB
gs-4321	379	8	vector	vector	NOUN
gs-4321	379	9	machines	machine	NOUN
gs-4321	379	10	,	,	PUNCT
gs-4321	379	11	deep	deep	ADJ
gs-4321	379	12	neural	neural	ADJ
gs-4321	379	13	networks	network	NOUN
gs-4321	379	14	,	,	PUNCT
gs-4321	379	15	and	and	CCONJ
gs-4321	379	16	graph	graph	NOUN
gs-4321	379	17	neural	neural	ADJ
gs-4321	379	18	networks	network	NOUN
gs-4321	379	19	have	have	AUX
gs-4321	379	20	shown	show	VERB
gs-4321	379	21	remarkable	remarkable	ADJ
gs-4321	379	22	capacity	capacity	NOUN
gs-4321	379	23	to	to	PART
gs-4321	379	24	generalize	generalize	VERB
gs-4321	379	25	across	across	ADP
gs-4321	379	26	datasets	dataset	NOUN
gs-4321	379	27	and	and	CCONJ
gs-4321	379	28	recognize	recognize	VERB
gs-4321	379	29	subtle	subtle	ADJ
gs-4321	379	30	features	feature	NOUN
gs-4321	379	31	predictive	predictive	ADJ
gs-4321	379	32	of	of	ADP
gs-4321	379	33	adaptive	adaptive	ADJ
gs-4321	379	34	transitions	transition	NOUN
gs-4321	379	35	(	(	PUNCT
gs-4321	379	36	lotfollahi	lotfollahi	X
gs-4321	379	37	et	et	PROPN
gs-4321	379	38	al	al	PROPN
gs-4321	379	39	.	.	PROPN
gs-4321	379	40	,	,	PUNCT
gs-4321	379	41	2019	2019	NUM
gs-4321	379	42	;	;	PUNCT
gs-4321	379	43	bergen	bergen	PROPN
gs-4321	379	44	et	et	PROPN
gs-4321	379	45	al	al	PROPN
gs-4321	379	46	.	.	PROPN
gs-4321	379	47	,	,	PUNCT
gs-4321	379	48	2020	2020	NUM
gs-4321	379	49	)	)	PUNCT
gs-4321	379	50	.	.	PUNCT
gs-4321	380	1	for	for	ADP
gs-4321	380	2	example	example	NOUN
gs-4321	380	3	,	,	PUNCT
gs-4321	380	4	deep	deep	ADJ
gs-4321	380	5	-	-	PUNCT
gs-4321	380	6	learning	learning	NOUN
gs-4321	380	7	–	–	PUNCT
gs-4321	380	8	based	base	VERB
gs-4321	380	9	autoencoders	autoencoder	NOUN
gs-4321	380	10	can	can	AUX
gs-4321	380	11	identify	identify	VERB
gs-4321	380	12	rare	rare	ADJ
gs-4321	380	13	subpopulations	subpopulation	NOUN
gs-4321	380	14	enriched	enrich	VERB
gs-4321	380	15	for	for	ADP
gs-4321	380	16	stem	stem	NOUN
gs-4321	380	17	-	-	PUNCT
gs-4321	380	18	like	like	ADJ
gs-4321	380	19	or	or	CCONJ
gs-4321	380	20	therapy	therapy	NOUN
gs-4321	380	21	-	-	PUNCT
gs-4321	380	22	resistant	resistant	ADJ
gs-4321	380	23	features	feature	NOUN
gs-4321	380	24	by	by	ADP
gs-4321	380	25	learning	learn	VERB
gs-4321	380	26	nonlinear	nonlinear	ADJ
gs-4321	380	27	manifolds	manifold	NOUN
gs-4321	380	28	representing	represent	VERB
gs-4321	380	29	intrinsic	intrinsic	ADJ
gs-4321	380	30	state	state	NOUN
gs-4321	380	31	structure	structure	NOUN
gs-4321	380	32	.	.	PUNCT
gs-4321	381	1	integration	integration	NOUN
gs-4321	381	2	of	of	ADP
gs-4321	381	3	these	these	DET
gs-4321	381	4	models	model	NOUN
gs-4321	381	5	with	with	ADP
gs-4321	381	6	regulatory	regulatory	ADJ
gs-4321	381	7	and	and	CCONJ
gs-4321	381	8	spatial	spatial	ADJ
gs-4321	381	9	data	datum	NOUN
gs-4321	381	10	produces	produce	VERB
gs-4321	381	11	powerful	powerful	ADJ
gs-4321	381	12	predictive	predictive	ADJ
gs-4321	381	13	frameworks	framework	NOUN
gs-4321	381	14	capable	capable	ADJ
gs-4321	381	15	of	of	ADP
gs-4321	381	16	forecasting	forecasting	NOUN
gs-4321	381	17	which	which	PRON
gs-4321	381	18	cells	cell	NOUN
gs-4321	381	19	are	be	AUX
gs-4321	381	20	most	most	ADV
gs-4321	381	21	likely	likely	ADJ
gs-4321	381	22	to	to	PART
gs-4321	381	23	undergo	undergo	VERB
gs-4321	381	24	adaptive	adaptive	ADJ
gs-4321	381	25	shifts	shift	NOUN
gs-4321	381	26	when	when	SCONJ
gs-4321	381	27	exposed	expose	VERB
gs-4321	381	28	to	to	ADP
gs-4321	381	29	specific	specific	ADJ
gs-4321	381	30	perturbations	perturbation	NOUN
gs-4321	381	31	.	.	PUNCT
gs-4321	382	1	toward	toward	ADP
gs-4321	382	2	a	a	DET
gs-4321	382	3	unified	unified	ADJ
gs-4321	382	4	understanding	understanding	NOUN
gs-4321	382	5	of	of	ADP
gs-4321	382	6	plasticity	plasticity	NOUN
gs-4321	382	7	the	the	DET
gs-4321	382	8	integration	integration	NOUN
gs-4321	382	9	of	of	ADP
gs-4321	382	10	computational	computational	ADJ
gs-4321	382	11	,	,	PUNCT
gs-4321	382	12	molecular	molecular	ADJ
gs-4321	382	13	,	,	PUNCT
gs-4321	382	14	and	and	CCONJ
gs-4321	382	15	ecological	ecological	ADJ
gs-4321	382	16	insights	insight	NOUN
gs-4321	382	17	provides	provide	VERB
gs-4321	382	18	a	a	DET
gs-4321	382	19	comprehensive	comprehensive	ADJ
gs-4321	382	20	foundation	foundation	NOUN
gs-4321	382	21	for	for	ADP
gs-4321	382	22	understanding	understand	VERB
gs-4321	382	23	how	how	SCONJ
gs-4321	382	24	malignant	malignant	ADJ
gs-4321	382	25	cells	cell	NOUN
gs-4321	382	26	acquire	acquire	VERB
gs-4321	382	27	and	and	CCONJ
gs-4321	382	28	maintain	maintain	VERB
gs-4321	382	29	adaptable	adaptable	ADJ
gs-4321	382	30	states	state	NOUN
gs-4321	382	31	.	.	PUNCT
gs-4321	383	1	by	by	ADP
gs-4321	383	2	combining	combine	VERB
gs-4321	383	3	multiomic	multiomic	ADJ
gs-4321	383	4	single	single	ADJ
gs-4321	383	5	-	-	PUNCT
gs-4321	383	6	cell	cell	NOUN
gs-4321	383	7	techniques	technique	NOUN
gs-4321	383	8	with	with	ADP
gs-4321	383	9	advanced	advanced	ADJ
gs-4321	383	10	georgian	georgian	NOUN
gs-4321	383	11	scientists/	scientists/	NUM
gs-4321	383	12	.	.	PUNCT
gs-4321	383	13	7	7	NUM
gs-4321	383	14	n	n	DET
gs-4321	383	15	4	4	NUM
gs-4321	383	16	,	,	PUNCT
gs-4321	383	17	2025	2025	NUM
gs-4321	383	18	357	357	NUM
gs-4321	383	19	bioinformatic	bioinformatic	ADJ
gs-4321	383	20	and	and	CCONJ
gs-4321	383	21	machine	machine	NOUN
gs-4321	383	22	-	-	PUNCT
gs-4321	383	23	learning	learn	VERB
gs-4321	383	24	tools	tool	NOUN
gs-4321	383	25	,	,	PUNCT
gs-4321	383	26	researchers	researcher	NOUN
gs-4321	383	27	can	can	AUX
gs-4321	383	28	now	now	ADV
gs-4321	383	29	reconstruct	reconstruct	VERB
gs-4321	383	30	the	the	DET
gs-4321	383	31	full	full	ADJ
gs-4321	383	32	complexity	complexity	NOUN
gs-4321	383	33	of	of	ADP
gs-4321	383	34	adaptive	adaptive	ADJ
gs-4321	383	35	trajectories	trajectory	NOUN
gs-4321	383	36	—	—	PUNCT
gs-4321	383	37	from	from	ADP
gs-4321	383	38	early	early	ADJ
gs-4321	383	39	transcriptional	transcriptional	ADJ
gs-4321	383	40	priming	priming	NOUN
gs-4321	383	41	to	to	ADP
gs-4321	383	42	stable	stable	ADJ
gs-4321	383	43	resistant	resistant	ADJ
gs-4321	383	44	phenotypes	phenotype	NOUN
gs-4321	383	45	.	.	PUNCT
gs-4321	384	1	this	this	DET
gs-4321	384	2	rapidly	rapidly	ADV
gs-4321	384	3	expanding	expand	VERB
gs-4321	384	4	field	field	NOUN
gs-4321	384	5	is	be	AUX
gs-4321	384	6	reshaping	reshape	VERB
gs-4321	384	7	contemporary	contemporary	ADJ
gs-4321	384	8	views	view	NOUN
gs-4321	384	9	of	of	ADP
gs-4321	384	10	tumor	tumor	NOUN
gs-4321	384	11	evolution	evolution	NOUN
gs-4321	384	12	and	and	CCONJ
gs-4321	384	13	creating	create	VERB
gs-4321	384	14	new	new	ADJ
gs-4321	384	15	opportunities	opportunity	NOUN
gs-4321	384	16	for	for	ADP
gs-4321	384	17	therapeutic	therapeutic	ADJ
gs-4321	384	18	intervention	intervention	NOUN
gs-4321	384	19	.	.	PUNCT
gs-4321	385	1	materials	material	NOUN
gs-4321	385	2	and	and	CCONJ
gs-4321	385	3	methods	method	NOUN
gs-4321	385	4	data	datum	NOUN
gs-4321	385	5	sources	source	NOUN
gs-4321	385	6	single	single	ADJ
gs-4321	385	7	-	-	PUNCT
gs-4321	385	8	cell	cell	NOUN
gs-4321	385	9	and	and	CCONJ
gs-4321	385	10	bulk	bulk	ADJ
gs-4321	385	11	transcriptomic	transcriptomic	ADJ
gs-4321	385	12	datasets	dataset	NOUN
gs-4321	385	13	were	be	AUX
gs-4321	385	14	obtained	obtain	VERB
gs-4321	385	15	from	from	ADP
gs-4321	385	16	multiple	multiple	ADJ
gs-4321	385	17	publicly	publicly	ADV
gs-4321	385	18	available	available	ADJ
gs-4321	385	19	repositories	repository	NOUN
gs-4321	385	20	.	.	PUNCT
gs-4321	386	1	single	single	ADJ
gs-4321	386	2	-	-	PUNCT
gs-4321	386	3	cell	cell	NOUN
gs-4321	386	4	rna	rna	NOUN
gs-4321	386	5	sequencing	sequence	VERB
gs-4321	386	6	(	(	PUNCT
gs-4321	386	7	scrna	scrna	NOUN
gs-4321	386	8	-	-	PUNCT
gs-4321	386	9	seq	seq	NOUN
gs-4321	386	10	)	)	PUNCT
gs-4321	386	11	datasets	dataset	NOUN
gs-4321	386	12	from	from	ADP
gs-4321	386	13	lung	lung	NOUN
gs-4321	386	14	,	,	PUNCT
gs-4321	386	15	breast	breast	NOUN
gs-4321	386	16	,	,	PUNCT
gs-4321	386	17	melanoma	melanoma	NOUN
gs-4321	386	18	,	,	PUNCT
gs-4321	386	19	and	and	CCONJ
gs-4321	386	20	colorectal	colorectal	ADJ
gs-4321	386	21	cancers	cancer	NOUN
gs-4321	386	22	were	be	AUX
gs-4321	386	23	downloaded	download	VERB
gs-4321	386	24	from	from	ADP
gs-4321	386	25	the	the	DET
gs-4321	386	26	gene	gene	NOUN
gs-4321	386	27	expression	expression	NOUN
gs-4321	386	28	omnibus	omnibus	NOUN
gs-4321	386	29	(	(	PUNCT
gs-4321	386	30	geo	geo	PROPN
gs-4321	386	31	)	)	PUNCT
gs-4321	386	32	and	and	CCONJ
gs-4321	386	33	arrayexpress	arrayexpress	NOUN
gs-4321	386	34	.	.	PUNCT
gs-4321	387	1	the	the	DET
gs-4321	387	2	primary	primary	ADJ
gs-4321	387	3	datasets	dataset	NOUN
gs-4321	387	4	included	include	VERB
gs-4321	387	5	:	:	PUNCT
gs-4321	387	6	gse131907	gse131907	NOUN
gs-4321	387	7	(	(	PUNCT
gs-4321	387	8	lung	lung	NOUN
gs-4321	387	9	cancer	cancer	NOUN
gs-4321	387	10	)	)	PUNCT
gs-4321	387	11	,	,	PUNCT
gs-4321	387	12	gse176078	gse176078	X
gs-4321	387	13	(	(	PUNCT
gs-4321	387	14	breast	breast	NOUN
gs-4321	387	15	cancer	cancer	NOUN
gs-4321	387	16	)	)	PUNCT
gs-4321	387	17	,	,	PUNCT
gs-4321	387	18	gse120575	gse120575	X
gs-4321	387	19	(	(	PUNCT
gs-4321	387	20	melanoma	melanoma	NOUN
gs-4321	387	21	)	)	PUNCT
gs-4321	387	22	,	,	PUNCT
gs-4321	387	23	and	and	CCONJ
gs-4321	387	24	gse144735	gse144735	NOUN
gs-4321	387	25	(	(	PUNCT
gs-4321	387	26	colorectal	colorectal	ADJ
gs-4321	387	27	carcinoma	carcinoma	NOUN
gs-4321	387	28	)	)	PUNCT
gs-4321	387	29	.	.	PUNCT
gs-4321	388	1	bulk	bulk	PROPN
gs-4321	388	2	rna	rna	PROPN
gs-4321	388	3	-	-	PUNCT
gs-4321	388	4	seq	seq	NOUN
gs-4321	388	5	,	,	PUNCT
gs-4321	388	6	mutation	mutation	NOUN
gs-4321	388	7	,	,	PUNCT
gs-4321	388	8	and	and	CCONJ
gs-4321	388	9	clinical	clinical	ADJ
gs-4321	388	10	data	datum	NOUN
gs-4321	388	11	were	be	AUX
gs-4321	388	12	retrieved	retrieve	VERB
gs-4321	388	13	from	from	ADP
gs-4321	388	14	the	the	DET
gs-4321	388	15	cancer	cancer	NOUN
gs-4321	388	16	genome	genome	NOUN
gs-4321	388	17	atlas	atlas	PROPN
gs-4321	388	18	(	(	PUNCT
gs-4321	388	19	tcga	tcga	PROPN
gs-4321	388	20	)	)	PUNCT
gs-4321	388	21	through	through	ADP
gs-4321	388	22	the	the	DET
gs-4321	388	23	genomic	genomic	ADJ
gs-4321	388	24	data	datum	NOUN
gs-4321	388	25	commons	common	NOUN
gs-4321	388	26	(	(	PUNCT
gs-4321	388	27	gdc	gdc	PROPN
gs-4321	388	28	)	)	PUNCT
gs-4321	388	29	.	.	PUNCT
gs-4321	389	1	additional	additional	ADJ
gs-4321	389	2	expression	expression	NOUN
gs-4321	389	3	and	and	CCONJ
gs-4321	389	4	dependency	dependency	NOUN
gs-4321	389	5	datasets	dataset	NOUN
gs-4321	389	6	were	be	AUX
gs-4321	389	7	obtained	obtain	VERB
gs-4321	389	8	from	from	ADP
gs-4321	389	9	the	the	DET
gs-4321	389	10	cancer	cancer	NOUN
gs-4321	389	11	cell	cell	NOUN
gs-4321	389	12	line	line	NOUN
gs-4321	389	13	encyclopedia	encyclopedia	NOUN
gs-4321	389	14	(	(	PUNCT
gs-4321	389	15	ccle	ccle	NOUN
gs-4321	389	16	)	)	PUNCT
gs-4321	389	17	.	.	PUNCT
gs-4321	390	1	all	all	DET
gs-4321	390	2	datasets	dataset	NOUN
gs-4321	390	3	were	be	AUX
gs-4321	390	4	processed	process	VERB
gs-4321	390	5	under	under	ADP
gs-4321	390	6	the	the	DET
gs-4321	390	7	licensing	licensing	NOUN
gs-4321	390	8	and	and	CCONJ
gs-4321	390	9	usage	usage	NOUN
gs-4321	390	10	guidelines	guideline	NOUN
gs-4321	390	11	of	of	ADP
gs-4321	390	12	the	the	DET
gs-4321	390	13	corresponding	corresponding	ADJ
gs-4321	390	14	repositories	repository	NOUN
gs-4321	390	15	.	.	PUNCT
gs-4321	391	1	preprocessing	preprocesse	VERB
gs-4321	391	2	of	of	ADP
gs-4321	391	3	single	single	ADJ
gs-4321	391	4	-	-	PUNCT
gs-4321	391	5	cell	cell	NOUN
gs-4321	391	6	data	datum	NOUN
gs-4321	391	7	raw	raw	ADJ
gs-4321	391	8	scrna	scrna	NOUN
gs-4321	391	9	-	-	PUNCT
gs-4321	391	10	seq	seq	NOUN
gs-4321	391	11	matrices	matrix	NOUN
gs-4321	391	12	were	be	AUX
gs-4321	391	13	processed	process	VERB
gs-4321	391	14	using	use	VERB
gs-4321	391	15	seurat	seurat	PROPN
gs-4321	391	16	v4.0	v4.0	PROPN
gs-4321	391	17	.	.	PUNCT
gs-4321	392	1	cells	cell	NOUN
gs-4321	392	2	with	with	ADP
gs-4321	392	3	<	<	X
gs-4321	392	4	200	200	NUM
gs-4321	392	5	detected	detect	VERB
gs-4321	392	6	genes	gene	NOUN
gs-4321	392	7	,	,	PUNCT
gs-4321	392	8	>	>	SYM
gs-4321	392	9	20	20	NUM
gs-4321	392	10	%	%	NOUN
gs-4321	392	11	mitochondrial	mitochondrial	ADJ
gs-4321	392	12	rna	rna	NOUN
gs-4321	392	13	content	content	NOUN
gs-4321	392	14	,	,	PUNCT
gs-4321	392	15	or	or	CCONJ
gs-4321	392	16	>	>	SYM
gs-4321	392	17	50,000	50,000	NUM
gs-4321	392	18	umi	umi	ADJ
gs-4321	392	19	counts	count	NOUN
gs-4321	392	20	were	be	AUX
gs-4321	392	21	removed	remove	VERB
gs-4321	392	22	.	.	PUNCT
gs-4321	393	1	genes	gene	NOUN
gs-4321	393	2	expressed	express	VERB
gs-4321	393	3	in	in	ADP
gs-4321	393	4	fewer	few	ADJ
gs-4321	393	5	than	than	ADP
gs-4321	393	6	three	three	NUM
gs-4321	393	7	cells	cell	NOUN
gs-4321	393	8	were	be	AUX
gs-4321	393	9	excluded	exclude	VERB
gs-4321	393	10	.	.	PUNCT
gs-4321	394	1	data	datum	NOUN
gs-4321	394	2	were	be	AUX
gs-4321	394	3	normalized	normalize	VERB
gs-4321	394	4	using	use	VERB
gs-4321	394	5	the	the	DET
gs-4321	394	6	“	"	PUNCT
gs-4321	394	7	lognormalize	lognormalize	NOUN
gs-4321	394	8	”	"	PUNCT
gs-4321	394	9	method	method	NOUN
gs-4321	394	10	and	and	CCONJ
gs-4321	394	11	scaled	scale	VERB
gs-4321	394	12	to	to	ADP
gs-4321	394	13	10,000	10,000	NUM
gs-4321	394	14	transcripts	transcript	NOUN
gs-4321	394	15	per	per	ADP
gs-4321	394	16	cell	cell	NOUN
gs-4321	394	17	.	.	PUNCT
gs-4321	395	1	highly	highly	ADV
gs-4321	395	2	variable	variable	ADJ
gs-4321	395	3	genes	gene	NOUN
gs-4321	395	4	were	be	AUX
gs-4321	395	5	identified	identify	VERB
gs-4321	395	6	using	use	VERB
gs-4321	395	7	the	the	DET
gs-4321	395	8	vst	vst	NOUN
gs-4321	395	9	algorithm	algorithm	NOUN
gs-4321	395	10	.	.	PUNCT
gs-4321	396	1	batch	batch	NOUN
gs-4321	396	2	effects	effect	NOUN
gs-4321	396	3	between	between	ADP
gs-4321	396	4	donors	donor	NOUN
gs-4321	396	5	and	and	CCONJ
gs-4321	396	6	experiments	experiment	NOUN
gs-4321	396	7	were	be	AUX
gs-4321	396	8	harmonized	harmonize	VERB
gs-4321	396	9	using	use	VERB
gs-4321	396	10	harmony	harmony	NOUN
gs-4321	396	11	.	.	PUNCT
gs-4321	397	1	dimensionality	dimensionality	NOUN
gs-4321	397	2	reduction	reduction	NOUN
gs-4321	397	3	was	be	AUX
gs-4321	397	4	performed	perform	VERB
gs-4321	397	5	using	use	VERB
gs-4321	397	6	principal	principal	ADJ
gs-4321	397	7	component	component	NOUN
gs-4321	397	8	analysis	analysis	NOUN
gs-4321	397	9	(	(	PUNCT
gs-4321	397	10	pca	pca	NOUN
gs-4321	397	11	)	)	PUNCT
gs-4321	397	12	,	,	PUNCT
gs-4321	397	13	followed	follow	VERB
gs-4321	397	14	by	by	ADP
gs-4321	397	15	umap	umap	NOUN
gs-4321	397	16	for	for	ADP
gs-4321	397	17	visualization	visualization	NOUN
gs-4321	397	18	.	.	PUNCT
gs-4321	398	1	clustering	clustering	NOUN
gs-4321	398	2	and	and	CCONJ
gs-4321	398	3	cell	cell	NOUN
gs-4321	398	4	-	-	PUNCT
gs-4321	398	5	type	type	NOUN
gs-4321	398	6	annotation	annotation	NOUN
gs-4321	398	7	shared	share	VERB
gs-4321	398	8	nearest	near	ADJ
gs-4321	398	9	neighbor	neighbor	NOUN
gs-4321	398	10	(	(	PUNCT
gs-4321	398	11	snn	snn	PROPN
gs-4321	398	12	)	)	PUNCT
gs-4321	398	13	clustering	clustering	NOUN
gs-4321	398	14	was	be	AUX
gs-4321	398	15	performed	perform	VERB
gs-4321	398	16	with	with	ADP
gs-4321	398	17	a	a	DET
gs-4321	398	18	resolution	resolution	NOUN
gs-4321	398	19	range	range	NOUN
gs-4321	398	20	of	of	ADP
gs-4321	398	21	0.4	0.4	NUM
gs-4321	398	22	—	—	PUNCT
gs-4321	398	23	1.2	1.2	NUM
gs-4321	398	24	,	,	PUNCT
gs-4321	398	25	optimized	optimize	VERB
gs-4321	398	26	per	per	ADP
gs-4321	398	27	dataset	dataset	NOUN
gs-4321	398	28	using	use	VERB
gs-4321	398	29	silhouette	silhouette	NOUN
gs-4321	398	30	metrics	metric	NOUN
gs-4321	398	31	.	.	PUNCT
gs-4321	399	1	clusters	cluster	NOUN
gs-4321	399	2	were	be	AUX
gs-4321	399	3	annotated	annotate	VERB
gs-4321	399	4	using	use	VERB
gs-4321	399	5	canonical	canonical	ADJ
gs-4321	399	6	markers	marker	NOUN
gs-4321	399	7	and	and	CCONJ
gs-4321	399	8	the	the	DET
gs-4321	399	9	singler	singler	NOUN
gs-4321	399	10	reference	reference	NOUN
gs-4321	399	11	-	-	PUNCT
gs-4321	399	12	based	base	VERB
gs-4321	399	13	classifier	classifier	NOUN
gs-4321	399	14	.	.	PUNCT
gs-4321	400	1	malignant	malignant	ADJ
gs-4321	400	2	cells	cell	NOUN
gs-4321	400	3	were	be	AUX
gs-4321	400	4	distinguished	distinguish	VERB
gs-4321	400	5	from	from	ADP
gs-4321	400	6	stromal	stromal	ADJ
gs-4321	400	7	and	and	CCONJ
gs-4321	400	8	immune	immune	ADJ
gs-4321	400	9	populations	population	NOUN
gs-4321	400	10	using	use	VERB
gs-4321	400	11	inferred	infer	VERB
gs-4321	400	12	copy	copy	NOUN
gs-4321	400	13	-	-	PUNCT
gs-4321	400	14	number	number	NOUN
gs-4321	400	15	variation	variation	NOUN
gs-4321	400	16	(	(	PUNCT
gs-4321	400	17	cnv	cnv	NOUN
gs-4321	400	18	)	)	PUNCT
gs-4321	400	19	profiles	profile	NOUN
gs-4321	400	20	generated	generate	VERB
gs-4321	400	21	with	with	ADP
gs-4321	400	22	infercnv	infercnv	NOUN
gs-4321	400	23	.	.	PUNCT
gs-4321	401	1	only	only	ADV
gs-4321	401	2	malignant	malignant	ADJ
gs-4321	401	3	cells	cell	NOUN
gs-4321	401	4	with	with	ADP
gs-4321	401	5	high	high	ADJ
gs-4321	401	6	-	-	PUNCT
gs-4321	401	7	confidence	confidence	NOUN
gs-4321	401	8	cnv	cnv	NOUN
gs-4321	401	9	patterns	pattern	NOUN
gs-4321	401	10	were	be	AUX
gs-4321	401	11	used	use	VERB
gs-4321	401	12	for	for	ADP
gs-4321	401	13	downstream	downstream	ADJ
gs-4321	401	14	plasticity	plasticity	NOUN
gs-4321	401	15	analyses	analysis	NOUN
gs-4321	401	16	.	.	PUNCT
gs-4321	402	1	trajectory	trajectory	NOUN
gs-4321	402	2	and	and	CCONJ
gs-4321	402	3	lineage	lineage	NOUN
gs-4321	402	4	inference	inference	NOUN
gs-4321	402	5	cell	cell	NOUN
gs-4321	402	6	-	-	PUNCT
gs-4321	402	7	state	state	NOUN
gs-4321	402	8	transitions	transition	NOUN
gs-4321	402	9	were	be	AUX
gs-4321	402	10	reconstructed	reconstruct	VERB
gs-4321	402	11	using	use	VERB
gs-4321	402	12	monocle3	monocle3	PROPN
gs-4321	402	13	,	,	PUNCT
gs-4321	402	14	slingshot	slingshot	NOUN
gs-4321	402	15	,	,	PUNCT
gs-4321	402	16	and	and	CCONJ
gs-4321	402	17	paga	paga	PROPN
gs-4321	402	18	.	.	PUNCT
gs-4321	403	1	pseudotime	pseudotime	PROPN
gs-4321	403	2	ordering	ordering	NOUN
gs-4321	403	3	was	be	AUX
gs-4321	403	4	based	base	VERB
gs-4321	403	5	on	on	ADP
gs-4321	403	6	reversed	reverse	VERB
gs-4321	403	7	graph	graph	NOUN
gs-4321	403	8	embedding	embed	VERB
gs-4321	403	9	.	.	PUNCT
gs-4321	404	1	to	to	PART
gs-4321	404	2	estimate	estimate	VERB
gs-4321	404	3	transcriptional	transcriptional	ADJ
gs-4321	404	4	directionality	directionality	NOUN
gs-4321	404	5	,	,	PUNCT
gs-4321	404	6	rna	rna	NOUN
gs-4321	404	7	velocity	velocity	NOUN
gs-4321	404	8	analysis	analysis	NOUN
gs-4321	404	9	was	be	AUX
gs-4321	404	10	performed	perform	VERB
gs-4321	404	11	using	use	VERB
gs-4321	404	12	scvelo	scvelo	NOUN
gs-4321	404	13	with	with	ADP
gs-4321	404	14	dynamical	dynamical	ADJ
gs-4321	404	15	modeling	modeling	NOUN
gs-4321	404	16	.	.	PUNCT
gs-4321	405	1	fate	fate	NOUN
gs-4321	405	2	probability	probability	NOUN
gs-4321	405	3	distributions	distribution	NOUN
gs-4321	405	4	were	be	AUX
gs-4321	405	5	inferred	infer	VERB
gs-4321	405	6	using	use	VERB
gs-4321	405	7	cellrank	cellrank	NOUN
gs-4321	405	8	.	.	PUNCT
gs-4321	406	1	branching	branch	VERB
gs-4321	406	2	points	point	NOUN
gs-4321	406	3	georgian	georgian	NOUN
gs-4321	406	4	scientists/	scientists/	NUM
gs-4321	406	5	.	.	PUNCT
gs-4321	406	6	7	7	NUM
gs-4321	406	7	n	n	DET
gs-4321	406	8	4	4	NUM
gs-4321	406	9	,	,	PUNCT
gs-4321	406	10	2025	2025	NUM
gs-4321	406	11	358	358	NUM
gs-4321	406	12	were	be	AUX
gs-4321	406	13	identified	identify	VERB
gs-4321	406	14	from	from	ADP
gs-4321	406	15	paga	paga	NOUN
gs-4321	406	16	graphs	graph	NOUN
gs-4321	406	17	,	,	PUNCT
gs-4321	406	18	and	and	CCONJ
gs-4321	406	19	lineage	lineage	NOUN
gs-4321	406	20	commitment	commitment	NOUN
gs-4321	406	21	scores	score	NOUN
gs-4321	406	22	were	be	AUX
gs-4321	406	23	calculated	calculate	VERB
gs-4321	406	24	using	use	VERB
gs-4321	406	25	principal	principal	ADJ
gs-4321	406	26	graph	graph	NOUN
gs-4321	406	27	topology	topology	NOUN
gs-4321	406	28	.	.	PUNCT
gs-4321	407	1	gene	gene	NOUN
gs-4321	407	2	regulatory	regulatory	ADJ
gs-4321	407	3	network	network	NOUN
gs-4321	407	4	analysis	analysis	NOUN
gs-4321	407	5	regulatory	regulatory	ADJ
gs-4321	407	6	network	network	NOUN
gs-4321	407	7	inference	inference	NOUN
gs-4321	407	8	was	be	AUX
gs-4321	407	9	performed	perform	VERB
gs-4321	407	10	using	use	VERB
gs-4321	407	11	scenic	scenic	ADJ
gs-4321	407	12	(	(	PUNCT
gs-4321	407	13	using	use	VERB
gs-4321	407	14	genie3	genie3	NOUN
gs-4321	407	15	and	and	CCONJ
gs-4321	407	16	rcistarget	rcistarget	NOUN
gs-4321	407	17	)	)	PUNCT
gs-4321	407	18	.	.	PUNCT
gs-4321	408	1	for	for	ADP
gs-4321	408	2	robustness	robustness	NOUN
gs-4321	408	3	,	,	PUNCT
gs-4321	408	4	grnboost2	grnboost2	PROPN
gs-4321	408	5	was	be	AUX
gs-4321	408	6	used	use	VERB
gs-4321	408	7	as	as	ADP
gs-4321	408	8	a	a	DET
gs-4321	408	9	parallel	parallel	ADJ
gs-4321	408	10	inference	inference	NOUN
gs-4321	408	11	method	method	NOUN
gs-4321	408	12	.	.	PUNCT
gs-4321	409	1	regulon	regulon	NOUN
gs-4321	409	2	specificity	specificity	NOUN
gs-4321	409	3	scores	score	NOUN
gs-4321	409	4	(	(	PUNCT
gs-4321	409	5	rss	rss	PROPN
gs-4321	409	6	)	)	PUNCT
gs-4321	409	7	were	be	AUX
gs-4321	409	8	calculated	calculate	VERB
gs-4321	409	9	to	to	PART
gs-4321	409	10	identify	identify	VERB
gs-4321	409	11	regulators	regulator	NOUN
gs-4321	409	12	defining	define	VERB
gs-4321	409	13	stem	stem	NOUN
gs-4321	409	14	-	-	PUNCT
gs-4321	409	15	like	like	ADJ
gs-4321	409	16	,	,	PUNCT
gs-4321	409	17	intermediate	intermediate	ADJ
gs-4321	409	18	,	,	PUNCT
gs-4321	409	19	and	and	CCONJ
gs-4321	409	20	differentiated	differentiated	ADJ
gs-4321	409	21	states	state	NOUN
gs-4321	409	22	.	.	PUNCT
gs-4321	410	1	chromatin	chromatin	NOUN
gs-4321	410	2	accessibility	accessibility	NOUN
gs-4321	410	3	(	(	PUNCT
gs-4321	410	4	atac	atac	NOUN
gs-4321	410	5	-	-	PUNCT
gs-4321	410	6	seq	seq	NOUN
gs-4321	410	7	)	)	PUNCT
gs-4321	410	8	data	datum	NOUN
gs-4321	410	9	from	from	ADP
gs-4321	410	10	matched	match	VERB
gs-4321	410	11	tumors	tumor	NOUN
gs-4321	410	12	(	(	PUNCT
gs-4321	410	13	when	when	SCONJ
gs-4321	410	14	available	available	ADJ
gs-4321	410	15	)	)	PUNCT
gs-4321	410	16	were	be	AUX
gs-4321	410	17	integrated	integrate	VERB
gs-4321	410	18	using	use	VERB
gs-4321	410	19	cicero	cicero	NOUN
gs-4321	410	20	to	to	PART
gs-4321	410	21	link	link	VERB
gs-4321	410	22	distal	distal	ADJ
gs-4321	410	23	regulatory	regulatory	ADJ
gs-4321	410	24	elements	element	NOUN
gs-4321	410	25	with	with	ADP
gs-4321	410	26	target	target	NOUN
gs-4321	410	27	genes	gene	NOUN
gs-4321	410	28	.	.	PUNCT
gs-4321	411	1	cell	cell	NOUN
gs-4321	411	2	–	–	PUNCT
gs-4321	411	3	cell	cell	NOUN
gs-4321	411	4	communication	communication	NOUN
gs-4321	411	5	analysis	analysis	NOUN
gs-4321	411	6	ligand	ligand	NOUN
gs-4321	411	7	–	–	PUNCT
gs-4321	411	8	receptor	receptor	NOUN
gs-4321	411	9	interactions	interaction	NOUN
gs-4321	411	10	were	be	AUX
gs-4321	411	11	inferred	infer	VERB
gs-4321	411	12	from	from	ADP
gs-4321	411	13	scrna	scrna	NOUN
gs-4321	411	14	-	-	PUNCT
gs-4321	411	15	seq	seq	NOUN
gs-4321	411	16	data	datum	NOUN
gs-4321	411	17	using	use	VERB
gs-4321	411	18	cellphonedb	cellphonedb	NOUN
gs-4321	411	19	,	,	PUNCT
gs-4321	411	20	cellchat	cellchat	NOUN
gs-4321	411	21	,	,	PUNCT
gs-4321	411	22	and	and	CCONJ
gs-4321	411	23	nichenet	nichenet	NOUN
gs-4321	411	24	.	.	PUNCT
gs-4321	412	1	only	only	ADV
gs-4321	412	2	ligand	ligand	ADJ
gs-4321	412	3	–	–	PUNCT
gs-4321	412	4	receptor	receptor	NOUN
gs-4321	412	5	pairs	pair	NOUN
gs-4321	412	6	with	with	ADP
gs-4321	412	7	significant	significant	ADJ
gs-4321	412	8	permutation	permutation	NOUN
gs-4321	412	9	-	-	PUNCT
gs-4321	412	10	based	base	VERB
gs-4321	412	11	pvalues	pvalue	NOUN
gs-4321	412	12	(	(	PUNCT
gs-4321	412	13	<	<	X
gs-4321	412	14	0.05	0.05	NUM
gs-4321	412	15	)	)	PUNCT
gs-4321	412	16	were	be	AUX
gs-4321	412	17	included	include	VERB
gs-4321	412	18	.	.	PUNCT
gs-4321	413	1	communication	communication	NOUN
gs-4321	413	2	networks	network	NOUN
gs-4321	413	3	were	be	AUX
gs-4321	413	4	stratified	stratify	VERB
gs-4321	413	5	across	across	ADP
gs-4321	413	6	spatial	spatial	ADJ
gs-4321	413	7	niches	niche	NOUN
gs-4321	413	8	and	and	CCONJ
gs-4321	413	9	malignant	malignant	ADJ
gs-4321	413	10	subpopulations	subpopulation	NOUN
gs-4321	413	11	to	to	PART
gs-4321	413	12	identify	identify	VERB
gs-4321	413	13	microenvironmental	microenvironmental	ADJ
gs-4321	413	14	regulators	regulator	NOUN
gs-4321	413	15	influencing	influence	VERB
gs-4321	413	16	plasticity	plasticity	NOUN
gs-4321	413	17	.	.	PUNCT
gs-4321	414	1	metabolic	metabolic	NOUN
gs-4321	414	2	and	and	CCONJ
gs-4321	414	3	pathway	pathway	NOUN
gs-4321	414	4	activity	activity	NOUN
gs-4321	414	5	inference	inference	NOUN
gs-4321	414	6	single	single	ADJ
gs-4321	414	7	-	-	PUNCT
gs-4321	414	8	cell	cell	NOUN
gs-4321	414	9	metabolic	metabolic	NOUN
gs-4321	414	10	states	state	NOUN
gs-4321	414	11	were	be	AUX
gs-4321	414	12	inferred	infer	VERB
gs-4321	414	13	using	use	VERB
gs-4321	414	14	scmetabolism	scmetabolism	NOUN
gs-4321	414	15	and	and	CCONJ
gs-4321	414	16	compass	compass	ADJ
gs-4321	414	17	.	.	PUNCT
gs-4321	415	1	pathway	pathway	NOUN
gs-4321	415	2	activities	activity	NOUN
gs-4321	415	3	for	for	ADP
gs-4321	415	4	gene	gene	NOUN
gs-4321	415	5	sets	set	NOUN
gs-4321	415	6	(	(	PUNCT
gs-4321	415	7	e.g.	e.g.	ADV
gs-4321	415	8	,	,	PUNCT
gs-4321	415	9	oxidative	oxidative	ADJ
gs-4321	415	10	phosphorylation	phosphorylation	NOUN
gs-4321	415	11	,	,	PUNCT
gs-4321	415	12	glycolysis	glycolysis	NOUN
gs-4321	415	13	,	,	PUNCT
gs-4321	415	14	emt	emt	PROPN
gs-4321	415	15	,	,	PUNCT
gs-4321	415	16	stress	stress	NOUN
gs-4321	415	17	response	response	NOUN
gs-4321	415	18	)	)	PUNCT
gs-4321	415	19	were	be	AUX
gs-4321	415	20	quantified	quantify	VERB
gs-4321	415	21	using	use	VERB
gs-4321	415	22	aucell	aucell	NOUN
gs-4321	415	23	and	and	CCONJ
gs-4321	415	24	gsva	gsva	NOUN
gs-4321	415	25	.	.	PUNCT
gs-4321	416	1	metabolic	metabolic	NOUN
gs-4321	416	2	flexibility	flexibility	NOUN
gs-4321	416	3	indices	index	NOUN
gs-4321	416	4	were	be	AUX
gs-4321	416	5	defined	define	VERB
gs-4321	416	6	as	as	ADP
gs-4321	416	7	the	the	DET
gs-4321	416	8	variance	variance	NOUN
gs-4321	416	9	of	of	ADP
gs-4321	416	10	pathway	pathway	NOUN
gs-4321	416	11	activity	activity	NOUN
gs-4321	416	12	across	across	ADP
gs-4321	416	13	pseudotime	pseudotime	ADJ
gs-4321	416	14	trajectories	trajectory	NOUN
gs-4321	416	15	.	.	PUNCT
gs-4321	417	1	stress	stress	NOUN
gs-4321	417	2	-	-	PUNCT
gs-4321	417	3	signature	signature	NOUN
gs-4321	417	4	enrichment	enrichment	NOUN
gs-4321	417	5	was	be	AUX
gs-4321	417	6	computed	compute	VERB
gs-4321	417	7	from	from	ADP
gs-4321	417	8	published	publish	VERB
gs-4321	417	9	gene	gene	NOUN
gs-4321	417	10	sets	set	NOUN
gs-4321	417	11	(	(	PUNCT
gs-4321	417	12	e.g.	e.g.	ADV
gs-4321	417	13	,	,	PUNCT
gs-4321	417	14	atf4	atf4	PROPN
gs-4321	417	15	,	,	PUNCT
gs-4321	417	16	nrf2	nrf2	PROPN
gs-4321	417	17	,	,	PUNCT
gs-4321	417	18	jnk	jnk	PROPN
gs-4321	417	19	pathways	pathway	NOUN
gs-4321	417	20	)	)	PUNCT
gs-4321	417	21	.	.	PUNCT
gs-4321	418	1	integration	integration	NOUN
gs-4321	418	2	of	of	ADP
gs-4321	418	3	multimodal	multimodal	NOUN
gs-4321	418	4	data	datum	NOUN
gs-4321	418	5	multimodal	multimodal	NOUN
gs-4321	418	6	integration	integration	NOUN
gs-4321	418	7	combining	combine	VERB
gs-4321	418	8	transcriptomic	transcriptomic	ADJ
gs-4321	418	9	,	,	PUNCT
gs-4321	418	10	epigenomic	epigenomic	ADJ
gs-4321	418	11	,	,	PUNCT
gs-4321	418	12	and	and	CCONJ
gs-4321	418	13	proteomic	proteomic	ADJ
gs-4321	418	14	features	feature	NOUN
gs-4321	418	15	was	be	AUX
gs-4321	418	16	performed	perform	VERB
gs-4321	418	17	using	use	VERB
gs-4321	418	18	seurat	seurat	PROPN
gs-4321	418	19	wnn	wnn	NOUN
gs-4321	418	20	analysis	analysis	NOUN
gs-4321	418	21	and	and	CCONJ
gs-4321	418	22	mofa+	mofa+	NOUN
gs-4321	418	23	.	.	PUNCT
gs-4321	419	1	pseudo	pseudo	NOUN
gs-4321	419	2	-	-	ADJ
gs-4321	419	3	bulk	bulk	ADJ
gs-4321	419	4	atac	atac	NOUN
gs-4321	419	5	-	-	PUNCT
gs-4321	419	6	seq	seq	NOUN
gs-4321	419	7	tracks	track	NOUN
gs-4321	419	8	and	and	CCONJ
gs-4321	419	9	mass	mass	ADJ
gs-4321	419	10	cytometry	cytometry	NOUN
gs-4321	419	11	–	–	PUNCT
gs-4321	419	12	derived	derive	VERB
gs-4321	419	13	protein	protein	NOUN
gs-4321	419	14	markers	marker	NOUN
gs-4321	419	15	were	be	AUX
gs-4321	419	16	projected	project	VERB
gs-4321	419	17	into	into	ADP
gs-4321	419	18	the	the	DET
gs-4321	419	19	same	same	ADJ
gs-4321	419	20	low	low	ADJ
gs-4321	419	21	-	-	PUNCT
gs-4321	419	22	dimensional	dimensional	ADJ
gs-4321	419	23	manifold	manifold	ADJ
gs-4321	419	24	using	use	VERB
gs-4321	419	25	mutual	mutual	ADJ
gs-4321	419	26	nearest	near	ADJ
gs-4321	419	27	neighbors	neighbor	NOUN
gs-4321	419	28	(	(	PUNCT
gs-4321	419	29	mnn	mnn	PROPN
gs-4321	419	30	)	)	PUNCT
gs-4321	419	31	matching	matching	NOUN
gs-4321	419	32	.	.	PUNCT
gs-4321	420	1	evolutionary	evolutionary	ADJ
gs-4321	420	2	and	and	CCONJ
gs-4321	420	3	clonal	clonal	ADJ
gs-4321	420	4	analyses	analysis	NOUN
gs-4321	420	5	phylogenetic	phylogenetic	ADJ
gs-4321	420	6	inference	inference	NOUN
gs-4321	420	7	was	be	AUX
gs-4321	420	8	conducted	conduct	VERB
gs-4321	420	9	using	use	VERB
gs-4321	420	10	scite	scite	PROPN
gs-4321	420	11	,	,	PUNCT
gs-4321	420	12	phiscs	phisc	NOUN
gs-4321	420	13	,	,	PUNCT
gs-4321	420	14	and	and	CCONJ
gs-4321	420	15	pyclone	pyclone	NOUN
gs-4321	420	16	for	for	ADP
gs-4321	420	17	datasets	dataset	NOUN
gs-4321	420	18	containing	contain	VERB
gs-4321	420	19	single	single	ADJ
gs-4321	420	20	-	-	PUNCT
gs-4321	420	21	cell	cell	NOUN
gs-4321	420	22	dna	dna	NOUN
gs-4321	420	23	variants	variant	NOUN
gs-4321	420	24	.	.	PUNCT
gs-4321	421	1	clonal	clonal	ADJ
gs-4321	421	2	expansions	expansion	NOUN
gs-4321	421	3	were	be	AUX
gs-4321	421	4	correlated	correlate	VERB
gs-4321	421	5	with	with	ADP
gs-4321	421	6	transcriptional	transcriptional	ADJ
gs-4321	421	7	states	state	NOUN
gs-4321	421	8	,	,	PUNCT
gs-4321	421	9	and	and	CCONJ
gs-4321	421	10	spatial	spatial	ADJ
gs-4321	421	11	localization	localization	NOUN
gs-4321	421	12	of	of	ADP
gs-4321	421	13	clones	clone	NOUN
gs-4321	421	14	was	be	AUX
gs-4321	421	15	assessed	assess	VERB
gs-4321	421	16	using	use	VERB
gs-4321	421	17	slide	slide	NOUN
gs-4321	421	18	-	-	PUNCT
gs-4321	421	19	seq	seq	NOUN
gs-4321	421	20	and	and	CCONJ
gs-4321	421	21	visium	visium	NOUN
gs-4321	421	22	datasets	dataset	NOUN
gs-4321	421	23	where	where	SCONJ
gs-4321	421	24	available	available	ADJ
gs-4321	421	25	.	.	PUNCT
gs-4321	422	1	statistical	statistical	ADJ
gs-4321	422	2	analysis	analysis	NOUN
gs-4321	422	3	comparisons	comparison	NOUN
gs-4321	422	4	between	between	ADP
gs-4321	422	5	groups	group	NOUN
gs-4321	422	6	were	be	AUX
gs-4321	422	7	performed	perform	VERB
gs-4321	422	8	using	use	VERB
gs-4321	422	9	wilcoxon	wilcoxon	ADJ
gs-4321	422	10	rank	rank	NOUN
gs-4321	422	11	-	-	PUNCT
gs-4321	422	12	sum	sum	NOUN
gs-4321	422	13	tests	test	NOUN
gs-4321	422	14	,	,	PUNCT
gs-4321	422	15	kruskal	kruskal	PROPN
gs-4321	422	16	–	–	PUNCT
gs-4321	422	17	wallis	wallis	PROPN
gs-4321	422	18	tests	test	NOUN
gs-4321	422	19	,	,	PUNCT
gs-4321	422	20	or	or	CCONJ
gs-4321	422	21	anova	anova	X
gs-4321	422	22	as	as	ADP
gs-4321	422	23	appropriate	appropriate	ADJ
gs-4321	422	24	.	.	PUNCT
gs-4321	423	1	multiple	multiple	ADJ
gs-4321	423	2	testing	testing	NOUN
gs-4321	423	3	corrections	correction	NOUN
gs-4321	423	4	were	be	AUX
gs-4321	423	5	performed	perform	VERB
gs-4321	423	6	using	use	VERB
gs-4321	423	7	benjamini	benjamini	NOUN
gs-4321	423	8	–	–	PUNCT
gs-4321	423	9	hochberg	hochberg	X
gs-4321	423	10	false	false	ADJ
gs-4321	423	11	discovery	discovery	NOUN
gs-4321	423	12	rate	rate	NOUN
gs-4321	423	13	(	(	PUNCT
gs-4321	423	14	fdr	fdr	PROPN
gs-4321	423	15	)	)	PUNCT
gs-4321	423	16	.	.	PUNCT
gs-4321	424	1	survival	survival	PROPN
gs-4321	424	2	associations	association	NOUN
gs-4321	424	3	were	be	AUX
gs-4321	424	4	assessed	assess	VERB
gs-4321	424	5	using	use	VERB
gs-4321	424	6	georgian	georgian	PROPN
gs-4321	424	7	scientists/	scientists/	NUM
gs-4321	424	8	.	.	PUNCT
gs-4321	425	1	7	7	NUM
gs-4321	425	2	n	n	DET
gs-4321	425	3	4	4	NUM
gs-4321	425	4	,	,	PUNCT
gs-4321	425	5	2025	2025	NUM
gs-4321	425	6	359	359	NUM
gs-4321	425	7	cox	cox	PROPN
gs-4321	425	8	proportional	proportional	NOUN
gs-4321	425	9	hazards	hazard	NOUN
gs-4321	425	10	models	model	NOUN
gs-4321	425	11	applied	apply	VERB
gs-4321	425	12	to	to	AUX
gs-4321	425	13	tcga	tcga	VERB
gs-4321	425	14	patient	patient	ADJ
gs-4321	425	15	cohorts	cohort	NOUN
gs-4321	425	16	.	.	PUNCT
gs-4321	426	1	significance	significance	NOUN
gs-4321	426	2	was	be	AUX
gs-4321	426	3	defined	define	VERB
gs-4321	426	4	as	as	ADP
gs-4321	426	5	fdr	fdr	PROPN
gs-4321	426	6	<	<	X
gs-4321	426	7	0.05	0.05	NUM
gs-4321	426	8	.	.	PUNCT
gs-4321	427	1	computational	computational	ADJ
gs-4321	427	2	environment	environment	NOUN
gs-4321	427	3	all	all	DET
gs-4321	427	4	analyses	analysis	NOUN
gs-4321	427	5	were	be	AUX
gs-4321	427	6	conducted	conduct	VERB
gs-4321	427	7	using	use	VERB
gs-4321	427	8	r	r	NOUN
gs-4321	427	9	(	(	PUNCT
gs-4321	427	10	v4.2	v4.2	PROPN
gs-4321	427	11	)	)	PUNCT
gs-4321	427	12	,	,	PUNCT
gs-4321	427	13	python	python	NOUN
gs-4321	427	14	(	(	PUNCT
gs-4321	427	15	v3.10	v3.10	PROPN
gs-4321	427	16	)	)	PUNCT
gs-4321	427	17	,	,	PUNCT
gs-4321	427	18	and	and	CCONJ
gs-4321	427	19	bioconductor	bioconductor	NOUN
gs-4321	427	20	packages	package	NOUN
gs-4321	427	21	.	.	PUNCT
gs-4321	428	1	high	high	ADJ
gs-4321	428	2	-	-	PUNCT
gs-4321	428	3	performance	performance	NOUN
gs-4321	428	4	computing	compute	VERB
gs-4321	428	5	clusters	cluster	NOUN
gs-4321	428	6	were	be	AUX
gs-4321	428	7	used	use	VERB
gs-4321	428	8	for	for	ADP
gs-4321	428	9	velocity	velocity	NOUN
gs-4321	428	10	modeling	modeling	NOUN
gs-4321	428	11	,	,	PUNCT
gs-4321	428	12	grn	grn	PROPN
gs-4321	428	13	inference	inference	PROPN
gs-4321	428	14	,	,	PUNCT
gs-4321	428	15	and	and	CCONJ
gs-4321	428	16	large	large	ADJ
gs-4321	428	17	-	-	PUNCT
gs-4321	428	18	scale	scale	NOUN
gs-4321	428	19	integration	integration	NOUN
gs-4321	428	20	.	.	PUNCT
gs-4321	429	1	code	code	NOUN
gs-4321	429	2	reproducibility	reproducibility	NOUN
gs-4321	429	3	was	be	AUX
gs-4321	429	4	ensured	ensure	VERB
gs-4321	429	5	through	through	ADP
gs-4321	429	6	containerized	containerized	ADJ
gs-4321	429	7	environments	environment	NOUN
gs-4321	429	8	(	(	PUNCT
gs-4321	429	9	docker	docker	NOUN
gs-4321	429	10	/	/	SYM
gs-4321	429	11	singularity	singularity	NOUN
gs-4321	429	12	)	)	PUNCT
gs-4321	429	13	.	.	PUNCT
gs-4321	430	1	results	result	VERB
gs-4321	430	2	integrated	integrate	VERB
gs-4321	430	3	single	single	ADJ
gs-4321	430	4	-	-	PUNCT
gs-4321	430	5	cell	cell	NOUN
gs-4321	430	6	transcriptomic	transcriptomic	ADJ
gs-4321	430	7	analysis	analysis	NOUN
gs-4321	430	8	revealed	reveal	VERB
gs-4321	430	9	a	a	DET
gs-4321	430	10	clear	clear	ADJ
gs-4321	430	11	organization	organization	NOUN
gs-4321	430	12	of	of	ADP
gs-4321	430	13	malignant	malignant	ADJ
gs-4321	430	14	cells	cell	NOUN
gs-4321	430	15	into	into	ADP
gs-4321	430	16	distinct	distinct	ADJ
gs-4321	430	17	yet	yet	ADV
gs-4321	430	18	interconnected	interconnected	ADJ
gs-4321	430	19	adaptive	adaptive	ADJ
gs-4321	430	20	states	state	NOUN
gs-4321	430	21	,	,	PUNCT
gs-4321	430	22	highlighting	highlight	VERB
gs-4321	430	23	the	the	DET
gs-4321	430	24	continuum	continuum	NOUN
gs-4321	430	25	of	of	ADP
gs-4321	430	26	phenotypic	phenotypic	ADJ
gs-4321	430	27	plasticity	plasticity	NOUN
gs-4321	430	28	within	within	ADP
gs-4321	430	29	the	the	DET
gs-4321	430	30	tumor	tumor	NOUN
gs-4321	430	31	ecosystem	ecosystem	NOUN
gs-4321	430	32	.	.	PUNCT
gs-4321	431	1	see	see	VERB
gs-4321	431	2	fig-2	fig-2	NOUN
gs-4321	431	3	.	.	PUNCT
gs-4321	432	1	the	the	DET
gs-4321	432	2	umap	umap	ADJ
gs-4321	432	3	projection	projection	NOUN
gs-4321	432	4	(	(	PUNCT
gs-4321	432	5	figure	figure	NOUN
gs-4321	432	6	2a	2a	NUM
gs-4321	432	7	)	)	PUNCT
gs-4321	432	8	demonstrated	demonstrate	VERB
gs-4321	432	9	three	three	NUM
gs-4321	432	10	dominant	dominant	ADJ
gs-4321	432	11	transcriptionally	transcriptionally	ADV
gs-4321	432	12	defined	define	VERB
gs-4321	432	13	states	state	NOUN
gs-4321	432	14	—	—	PUNCT
gs-4321	432	15	differentiated	differentiated	ADJ
gs-4321	432	16	,	,	PUNCT
gs-4321	432	17	intermediate	intermediate	ADJ
gs-4321	432	18	,	,	PUNCT
gs-4321	432	19	and	and	CCONJ
gs-4321	432	20	stem	stem	NOUN
gs-4321	432	21	-	-	PUNCT
gs-4321	432	22	like	like	NOUN
gs-4321	432	23	—	—	PUNCT
gs-4321	432	24	each	each	DET
gs-4321	432	25	forming	form	VERB
gs-4321	432	26	coherent	coherent	ADJ
gs-4321	432	27	clusters	cluster	NOUN
gs-4321	432	28	but	but	CCONJ
gs-4321	432	29	maintaining	maintain	VERB
gs-4321	432	30	smooth	smooth	ADJ
gs-4321	432	31	spatial	spatial	ADJ
gs-4321	432	32	transitions	transition	NOUN
gs-4321	432	33	between	between	ADP
gs-4321	432	34	one	one	NUM
gs-4321	432	35	another	another	DET
gs-4321	432	36	.	.	PUNCT
gs-4321	433	1	differentiated	differentiated	ADJ
gs-4321	433	2	cells	cell	NOUN
gs-4321	433	3	occupied	occupy	VERB
gs-4321	433	4	a	a	DET
gs-4321	433	5	more	more	ADV
gs-4321	433	6	compact	compact	ADJ
gs-4321	433	7	and	and	CCONJ
gs-4321	433	8	transcriptionally	transcriptionally	ADV
gs-4321	433	9	stable	stable	ADJ
gs-4321	433	10	region	region	NOUN
gs-4321	433	11	,	,	PUNCT
gs-4321	433	12	whereas	whereas	SCONJ
gs-4321	433	13	intermediate	intermediate	ADJ
gs-4321	433	14	cells	cell	NOUN
gs-4321	433	15	bridged	bridge	VERB
gs-4321	433	16	this	this	DET
gs-4321	433	17	compartment	compartment	NOUN
gs-4321	433	18	with	with	ADP
gs-4321	433	19	the	the	DET
gs-4321	433	20	more	more	ADV
gs-4321	433	21	dispersed	disperse	VERB
gs-4321	433	22	stem	stem	NOUN
gs-4321	433	23	-	-	PUNCT
gs-4321	433	24	like	like	ADJ
gs-4321	433	25	population	population	NOUN
gs-4321	433	26	.	.	PUNCT
gs-4321	434	1	this	this	DET
gs-4321	434	2	spatial	spatial	ADJ
gs-4321	434	3	arrangement	arrangement	NOUN
gs-4321	434	4	suggested	suggest	VERB
gs-4321	434	5	that	that	SCONJ
gs-4321	434	6	malignant	malignant	ADJ
gs-4321	434	7	cells	cell	NOUN
gs-4321	434	8	do	do	AUX
gs-4321	434	9	not	not	PART
gs-4321	434	10	exist	exist	VERB
gs-4321	434	11	as	as	ADP
gs-4321	434	12	fixed	fix	VERB
gs-4321	434	13	entities	entity	NOUN
gs-4321	434	14	but	but	CCONJ
gs-4321	434	15	rather	rather	ADV
gs-4321	434	16	populate	populate	VERB
gs-4321	434	17	a	a	DET
gs-4321	434	18	dynamic	dynamic	ADJ
gs-4321	434	19	landscape	landscape	NOUN
gs-4321	434	20	governed	govern	VERB
gs-4321	434	21	by	by	ADP
gs-4321	434	22	continuous	continuous	ADJ
gs-4321	434	23	regulatory	regulatory	ADJ
gs-4321	434	24	gradients	gradient	NOUN
gs-4321	434	25	.	.	PUNCT
gs-4321	435	1	the	the	DET
gs-4321	435	2	computation	computation	NOUN
gs-4321	435	3	of	of	ADP
gs-4321	435	4	stemness	stemness	ADJ
gs-4321	435	5	scores	score	NOUN
gs-4321	435	6	across	across	ADP
gs-4321	435	7	the	the	DET
gs-4321	435	8	embedding	embed	VERB
gs-4321	435	9	(	(	PUNCT
gs-4321	435	10	figure	figure	NOUN
gs-4321	435	11	2b	2b	NOUN
gs-4321	435	12	)	)	PUNCT
gs-4321	435	13	reinforced	reinforce	VERB
gs-4321	435	14	this	this	DET
gs-4321	435	15	observation	observation	NOUN
gs-4321	435	16	.	.	PUNCT
gs-4321	436	1	cells	cell	NOUN
gs-4321	436	2	within	within	ADP
gs-4321	436	3	the	the	DET
gs-4321	436	4	differentiated	differentiated	ADJ
gs-4321	436	5	compartment	compartment	NOUN
gs-4321	436	6	displayed	display	VERB
gs-4321	436	7	the	the	DET
gs-4321	436	8	lowest	low	ADJ
gs-4321	436	9	stemness	stemness	ADJ
gs-4321	436	10	levels	level	NOUN
gs-4321	436	11	,	,	PUNCT
gs-4321	436	12	whereas	whereas	SCONJ
gs-4321	436	13	the	the	DET
gs-4321	436	14	intermediate	intermediate	ADJ
gs-4321	436	15	state	state	NOUN
gs-4321	436	16	exhibited	exhibit	VERB
gs-4321	436	17	a	a	DET
gs-4321	436	18	measurable	measurable	ADJ
gs-4321	436	19	increase	increase	NOUN
gs-4321	436	20	,	,	PUNCT
gs-4321	436	21	positioning	position	VERB
gs-4321	436	22	it	it	PRON
gs-4321	436	23	as	as	ADP
gs-4321	436	24	a	a	DET
gs-4321	436	25	transitional	transitional	ADJ
gs-4321	436	26	phenotype	phenotype	NOUN
gs-4321	436	27	.	.	PUNCT
gs-4321	437	1	the	the	DET
gs-4321	437	2	stem	stem	NOUN
gs-4321	437	3	-	-	PUNCT
gs-4321	437	4	like	like	ADJ
gs-4321	437	5	cluster	cluster	NOUN
gs-4321	437	6	displayed	display	VERB
gs-4321	437	7	the	the	DET
gs-4321	437	8	highest	high	ADJ
gs-4321	437	9	stemness	stemness	ADJ
gs-4321	437	10	scores	score	NOUN
gs-4321	437	11	,	,	PUNCT
gs-4321	437	12	corresponding	correspond	VERB
gs-4321	437	13	to	to	ADP
gs-4321	437	14	enriched	enrich	VERB
gs-4321	437	15	activation	activation	NOUN
gs-4321	437	16	of	of	ADP
gs-4321	437	17	programs	program	NOUN
gs-4321	437	18	associated	associate	VERB
gs-4321	437	19	with	with	ADP
gs-4321	437	20	self	self	NOUN
gs-4321	437	21	-	-	PUNCT
gs-4321	437	22	renewal	renewal	NOUN
gs-4321	437	23	,	,	PUNCT
gs-4321	437	24	survival	survival	NOUN
gs-4321	437	25	,	,	PUNCT
gs-4321	437	26	and	and	CCONJ
gs-4321	437	27	therapeutic	therapeutic	ADJ
gs-4321	437	28	resilience	resilience	NOUN
gs-4321	437	29	.	.	PUNCT
gs-4321	438	1	the	the	DET
gs-4321	438	2	gradient	gradient	NOUN
gs-4321	438	3	-	-	PUNCT
gs-4321	438	4	like	like	ADJ
gs-4321	438	5	distribution	distribution	NOUN
gs-4321	438	6	across	across	ADP
gs-4321	438	7	all	all	DET
gs-4321	438	8	malignant	malignant	ADJ
gs-4321	438	9	cells	cell	NOUN
gs-4321	438	10	supported	support	VERB
gs-4321	438	11	a	a	DET
gs-4321	438	12	model	model	NOUN
gs-4321	438	13	in	in	ADP
gs-4321	438	14	which	which	PRON
gs-4321	438	15	dedifferentiation	dedifferentiation	NOUN
gs-4321	438	16	proceeds	proceed	VERB
gs-4321	438	17	incrementally	incrementally	ADV
gs-4321	438	18	,	,	PUNCT
gs-4321	438	19	rather	rather	ADV
gs-4321	438	20	than	than	ADP
gs-4321	438	21	through	through	ADP
gs-4321	438	22	abrupt	abrupt	ADJ
gs-4321	438	23	shifts	shift	NOUN
gs-4321	438	24	,	,	PUNCT
gs-4321	438	25	thereby	thereby	ADV
gs-4321	438	26	enabling	enable	VERB
gs-4321	438	27	tumors	tumor	NOUN
gs-4321	438	28	to	to	PART
gs-4321	438	29	diversify	diversify	VERB
gs-4321	438	30	their	their	PRON
gs-4321	438	31	phenotypic	phenotypic	ADJ
gs-4321	438	32	repertoire	repertoire	NOUN
gs-4321	438	33	.	.	PUNCT
gs-4321	439	1	dynamic	dynamic	ADJ
gs-4321	439	2	transition	transition	NOUN
gs-4321	439	3	mapping	mapping	NOUN
gs-4321	439	4	(	(	PUNCT
gs-4321	439	5	figure	figure	NOUN
gs-4321	439	6	2c	2c	NUM
gs-4321	439	7	)	)	PUNCT
gs-4321	439	8	provided	provide	VERB
gs-4321	439	9	further	further	ADJ
gs-4321	439	10	insight	insight	NOUN
gs-4321	439	11	into	into	ADP
gs-4321	439	12	the	the	DET
gs-4321	439	13	directional	directional	ADJ
gs-4321	439	14	behavior	behavior	NOUN
gs-4321	439	15	of	of	ADP
gs-4321	439	16	malignant	malignant	ADJ
gs-4321	439	17	cells	cell	NOUN
gs-4321	439	18	.	.	PUNCT
gs-4321	440	1	streamline	streamline	PROPN
gs-4321	440	2	trajectories	trajectory	NOUN
gs-4321	440	3	indicated	indicate	VERB
gs-4321	440	4	a	a	DET
gs-4321	440	5	consistent	consistent	ADJ
gs-4321	440	6	flow	flow	NOUN
gs-4321	440	7	from	from	ADP
gs-4321	440	8	differentiated	differentiate	VERB
gs-4321	440	9	toward	toward	ADP
gs-4321	440	10	intermediate	intermediate	ADJ
gs-4321	440	11	and	and	CCONJ
gs-4321	440	12	subsequently	subsequently	ADV
gs-4321	440	13	stem	stem	VERB
gs-4321	440	14	-	-	PUNCT
gs-4321	440	15	like	like	ADJ
gs-4321	440	16	regions	region	NOUN
gs-4321	440	17	,	,	PUNCT
gs-4321	440	18	reflecting	reflect	VERB
gs-4321	440	19	a	a	DET
gs-4321	440	20	longitudinal	longitudinal	ADJ
gs-4321	440	21	process	process	NOUN
gs-4321	440	22	of	of	ADP
gs-4321	440	23	phenotypic	phenotypic	ADJ
gs-4321	440	24	adaptation	adaptation	NOUN
gs-4321	440	25	.	.	PUNCT
gs-4321	441	1	this	this	DET
gs-4321	441	2	directional	directional	ADJ
gs-4321	441	3	movement	movement	NOUN
gs-4321	441	4	underscores	underscore	VERB
gs-4321	441	5	the	the	DET
gs-4321	441	6	active	active	ADJ
gs-4321	441	7	engagement	engagement	NOUN
gs-4321	441	8	of	of	ADP
gs-4321	441	9	malignant	malignant	ADJ
gs-4321	441	10	cells	cell	NOUN
gs-4321	441	11	in	in	ADP
gs-4321	441	12	acquiring	acquire	VERB
gs-4321	441	13	traits	trait	NOUN
gs-4321	441	14	associated	associate	VERB
gs-4321	441	15	with	with	ADP
gs-4321	441	16	invasiveness	invasiveness	ADJ
gs-4321	441	17	,	,	PUNCT
gs-4321	441	18	resistance	resistance	NOUN
gs-4321	441	19	,	,	PUNCT
gs-4321	441	20	and	and	CCONJ
gs-4321	441	21	metabolic	metabolic	NOUN
gs-4321	441	22	reprogramming	reprogramming	NOUN
gs-4321	441	23	.	.	PUNCT
gs-4321	442	1	the	the	DET
gs-4321	442	2	dominance	dominance	NOUN
gs-4321	442	3	of	of	ADP
gs-4321	442	4	forward	forward	ADV
gs-4321	442	5	-	-	PUNCT
gs-4321	442	6	directed	direct	VERB
gs-4321	442	7	transitions	transition	NOUN
gs-4321	442	8	suggested	suggest	VERB
gs-4321	442	9	that	that	SCONJ
gs-4321	442	10	the	the	DET
gs-4321	442	11	tumor	tumor	NOUN
gs-4321	442	12	microenvironment	microenvironment	NOUN
gs-4321	442	13	may	may	AUX
gs-4321	442	14	exert	exert	VERB
gs-4321	442	15	selective	selective	ADJ
gs-4321	442	16	pressures	pressure	NOUN
gs-4321	442	17	that	that	PRON
gs-4321	442	18	favor	favor	VERB
gs-4321	442	19	the	the	DET
gs-4321	442	20	emergence	emergence	NOUN
gs-4321	442	21	and	and	CCONJ
gs-4321	442	22	persistence	persistence	NOUN
gs-4321	442	23	of	of	ADP
gs-4321	442	24	higher	high	ADJ
gs-4321	442	25	-	-	PUNCT
gs-4321	442	26	plasticity	plasticity	NOUN
gs-4321	442	27	cellular	cellular	ADJ
gs-4321	442	28	states	state	NOUN
gs-4321	442	29	.	.	PUNCT
gs-4321	443	1	regulatory	regulatory	ADJ
gs-4321	443	2	factor	factor	NOUN
gs-4321	443	3	analysis	analysis	NOUN
gs-4321	443	4	revealed	reveal	VERB
gs-4321	443	5	coordinated	coordinated	ADJ
gs-4321	443	6	shifts	shift	NOUN
gs-4321	443	7	in	in	ADP
gs-4321	443	8	the	the	DET
gs-4321	443	9	activity	activity	NOUN
gs-4321	443	10	of	of	ADP
gs-4321	443	11	key	key	ADJ
gs-4321	443	12	transcriptional	transcriptional	ADJ
gs-4321	443	13	regulators	regulator	NOUN
gs-4321	443	14	across	across	ADP
gs-4321	443	15	the	the	DET
gs-4321	443	16	three	three	NUM
gs-4321	443	17	states	state	NOUN
gs-4321	443	18	(	(	PUNCT
gs-4321	443	19	figure	figure	NOUN
gs-4321	443	20	2d	2d	NUM
gs-4321	443	21	)	)	PUNCT
gs-4321	443	22	.	.	PUNCT
gs-4321	444	1	sox2	sox2	NOUN
gs-4321	444	2	and	and	CCONJ
gs-4321	444	3	zeb1	zeb1	PROPN
gs-4321	444	4	,	,	PUNCT
gs-4321	444	5	widely	widely	ADV
gs-4321	444	6	associated	associate	VERB
gs-4321	444	7	with	with	ADP
gs-4321	444	8	stemness	stemness	ADJ
gs-4321	444	9	and	and	CCONJ
gs-4321	444	10	epithelial	epithelial	ADJ
gs-4321	444	11	–	–	PUNCT
gs-4321	444	12	mesenchymal	mesenchymal	ADJ
gs-4321	444	13	transition	transition	NOUN
gs-4321	444	14	,	,	PUNCT
gs-4321	444	15	exhibited	exhibit	VERB
gs-4321	444	16	the	the	DET
gs-4321	444	17	most	most	ADV
gs-4321	444	18	pronounced	pronounce	VERB
gs-4321	444	19	georgian	georgian	NOUN
gs-4321	444	20	scientists/	scientists/	NUM
gs-4321	444	21	.	.	PUNCT
gs-4321	445	1	7	7	NUM
gs-4321	445	2	n	n	DET
gs-4321	445	3	4	4	NUM
gs-4321	445	4	,	,	PUNCT
gs-4321	445	5	2025	2025	NUM
gs-4321	445	6	360	360	NUM
gs-4321	445	7	upregulation	upregulation	NOUN
gs-4321	445	8	in	in	ADP
gs-4321	445	9	stem	stem	NOUN
gs-4321	445	10	-	-	PUNCT
gs-4321	445	11	like	like	ADJ
gs-4321	445	12	cells	cell	NOUN
gs-4321	445	13	.	.	PUNCT
gs-4321	446	1	jun	jun	PROPN
gs-4321	446	2	showed	show	VERB
gs-4321	446	3	a	a	DET
gs-4321	446	4	steady	steady	ADJ
gs-4321	446	5	increase	increase	NOUN
gs-4321	446	6	from	from	ADP
gs-4321	446	7	differentiated	differentiate	VERB
gs-4321	446	8	to	to	ADP
gs-4321	446	9	intermediate	intermediate	ADJ
gs-4321	446	10	states	state	NOUN
gs-4321	446	11	,	,	PUNCT
gs-4321	446	12	consistent	consistent	ADJ
gs-4321	446	13	with	with	ADP
gs-4321	446	14	its	its	PRON
gs-4321	446	15	involvement	involvement	NOUN
gs-4321	446	16	in	in	ADP
gs-4321	446	17	stress	stress	NOUN
gs-4321	446	18	-	-	PUNCT
gs-4321	446	19	response	response	NOUN
gs-4321	446	20	pathways	pathway	NOUN
gs-4321	446	21	that	that	PRON
gs-4321	446	22	promote	promote	VERB
gs-4321	446	23	adaptability	adaptability	NOUN
gs-4321	446	24	.	.	PUNCT
gs-4321	447	1	conversely	conversely	ADV
gs-4321	447	2	,	,	PUNCT
gs-4321	447	3	mitf	mitf	PROPN
gs-4321	447	4	displayed	display	VERB
gs-4321	447	5	a	a	DET
gs-4321	447	6	more	more	ADV
gs-4321	447	7	complex	complex	ADJ
gs-4321	447	8	pattern	pattern	NOUN
gs-4321	447	9	,	,	PUNCT
gs-4321	447	10	declining	decline	VERB
gs-4321	447	11	in	in	ADP
gs-4321	447	12	intermediate	intermediate	ADJ
gs-4321	447	13	states	state	NOUN
gs-4321	447	14	and	and	CCONJ
gs-4321	447	15	rising	rise	VERB
gs-4321	447	16	modestly	modestly	ADV
gs-4321	447	17	in	in	ADP
gs-4321	447	18	stem	stem	NOUN
gs-4321	447	19	-	-	PUNCT
gs-4321	447	20	like	like	ADJ
gs-4321	447	21	cells	cell	NOUN
gs-4321	447	22	,	,	PUNCT
gs-4321	447	23	suggesting	suggest	VERB
gs-4321	447	24	context	context	NOUN
gs-4321	447	25	-	-	PUNCT
gs-4321	447	26	dependent	dependent	ADJ
gs-4321	447	27	roles	role	NOUN
gs-4321	447	28	in	in	ADP
gs-4321	447	29	balancing	balance	VERB
gs-4321	447	30	differentiation	differentiation	NOUN
gs-4321	447	31	and	and	CCONJ
gs-4321	447	32	plasticity	plasticity	NOUN
gs-4321	447	33	.	.	PUNCT
gs-4321	448	1	collectively	collectively	ADV
gs-4321	448	2	,	,	PUNCT
gs-4321	448	3	the	the	DET
gs-4321	448	4	graded	grade	VERB
gs-4321	448	5	expression	expression	NOUN
gs-4321	448	6	and	and	CCONJ
gs-4321	448	7	activity	activity	NOUN
gs-4321	448	8	profiles	profile	NOUN
gs-4321	448	9	of	of	ADP
gs-4321	448	10	these	these	DET
gs-4321	448	11	regulators	regulator	NOUN
gs-4321	448	12	aligned	align	VERB
gs-4321	448	13	with	with	ADP
gs-4321	448	14	the	the	DET
gs-4321	448	15	observed	observe	VERB
gs-4321	448	16	trajectory	trajectory	NOUN
gs-4321	448	17	patterns	pattern	NOUN
gs-4321	448	18	and	and	CCONJ
gs-4321	448	19	stemness	stemness	ADJ
gs-4321	448	20	gradients	gradient	NOUN
gs-4321	448	21	.	.	PUNCT
gs-4321	449	1	overall	overall	ADV
gs-4321	449	2	,	,	PUNCT
gs-4321	449	3	the	the	DET
gs-4321	449	4	integrated	integrate	VERB
gs-4321	449	5	analysis	analysis	NOUN
gs-4321	449	6	delineates	delineate	VERB
gs-4321	449	7	a	a	DET
gs-4321	449	8	hierarchical	hierarchical	ADJ
gs-4321	449	9	yet	yet	CCONJ
gs-4321	449	10	fluid	fluid	ADJ
gs-4321	449	11	malignant	malignant	ADJ
gs-4321	449	12	cell	cell	NOUN
gs-4321	449	13	spectrum	spectrum	NOUN
gs-4321	449	14	,	,	PUNCT
gs-4321	449	15	governed	govern	VERB
gs-4321	449	16	by	by	ADP
gs-4321	449	17	progressive	progressive	ADJ
gs-4321	449	18	transcriptomic	transcriptomic	ADJ
gs-4321	449	19	reprogramming	reprogramming	NOUN
gs-4321	449	20	and	and	CCONJ
gs-4321	449	21	orchestrated	orchestrate	VERB
gs-4321	449	22	by	by	ADP
gs-4321	449	23	key	key	ADJ
gs-4321	449	24	regulatory	regulatory	ADJ
gs-4321	449	25	networks	network	NOUN
gs-4321	449	26	that	that	PRON
gs-4321	449	27	enable	enable	VERB
gs-4321	449	28	tumors	tumor	NOUN
gs-4321	449	29	to	to	PART
gs-4321	449	30	transition	transition	VERB
gs-4321	449	31	toward	toward	ADP
gs-4321	449	32	more	more	ADV
gs-4321	449	33	adaptive	adaptive	ADJ
gs-4321	449	34	and	and	CCONJ
gs-4321	449	35	stem	stem	NOUN
gs-4321	449	36	-	-	PUNCT
gs-4321	449	37	like	like	ADJ
gs-4321	449	38	phenotypes	phenotype	NOUN
gs-4321	449	39	.	.	PUNCT
gs-4321	450	1	further	further	ADJ
gs-4321	450	2	examination	examination	NOUN
gs-4321	450	3	of	of	ADP
gs-4321	450	4	intercellular	intercellular	ADJ
gs-4321	450	5	variability	variability	NOUN
gs-4321	450	6	within	within	ADP
gs-4321	450	7	each	each	DET
gs-4321	450	8	malignant	malignant	ADJ
gs-4321	450	9	state	state	NOUN
gs-4321	450	10	revealed	reveal	VERB
gs-4321	450	11	substantial	substantial	ADJ
gs-4321	450	12	heterogeneity	heterogeneity	NOUN
gs-4321	450	13	that	that	PRON
gs-4321	450	14	reflects	reflect	VERB
gs-4321	450	15	microenvironmental	microenvironmental	ADJ
gs-4321	450	16	influences	influence	NOUN
gs-4321	450	17	and	and	CCONJ
gs-4321	450	18	intrinsic	intrinsic	ADJ
gs-4321	450	19	regulatory	regulatory	ADJ
gs-4321	450	20	divergence	divergence	NOUN
gs-4321	450	21	.	.	PUNCT
gs-4321	451	1	within	within	ADP
gs-4321	451	2	the	the	DET
gs-4321	451	3	intermediate	intermediate	ADJ
gs-4321	451	4	population	population	NOUN
gs-4321	451	5	,	,	PUNCT
gs-4321	451	6	subclusters	subcluster	NOUN
gs-4321	451	7	emerged	emerge	VERB
gs-4321	451	8	that	that	PRON
gs-4321	451	9	displayed	display	VERB
gs-4321	451	10	partial	partial	ADJ
gs-4321	451	11	activation	activation	NOUN
gs-4321	451	12	of	of	ADP
gs-4321	451	13	stem	stem	NOUN
gs-4321	451	14	-	-	PUNCT
gs-4321	451	15	like	like	ADJ
gs-4321	451	16	programs	program	NOUN
gs-4321	451	17	while	while	SCONJ
gs-4321	451	18	retaining	retain	VERB
gs-4321	451	19	elements	element	NOUN
gs-4321	451	20	of	of	ADP
gs-4321	451	21	differentiated	differentiated	ADJ
gs-4321	451	22	identity	identity	NOUN
gs-4321	451	23	.	.	PUNCT
gs-4321	452	1	this	this	DET
gs-4321	452	2	hybrid	hybrid	ADJ
gs-4321	452	3	transcriptional	transcriptional	ADJ
gs-4321	452	4	configuration	configuration	NOUN
gs-4321	452	5	suggests	suggest	VERB
gs-4321	452	6	that	that	SCONJ
gs-4321	452	7	intermediate	intermediate	ADJ
gs-4321	452	8	cells	cell	NOUN
gs-4321	452	9	may	may	AUX
gs-4321	452	10	function	function	VERB
gs-4321	452	11	as	as	ADP
gs-4321	452	12	a	a	DET
gs-4321	452	13	reservoir	reservoir	NOUN
gs-4321	452	14	of	of	ADP
gs-4321	452	15	adaptable	adaptable	ADJ
gs-4321	452	16	phenotypes	phenotype	NOUN
gs-4321	452	17	capable	capable	ADJ
gs-4321	452	18	of	of	ADP
gs-4321	452	19	rapidly	rapidly	ADV
gs-4321	452	20	shifting	shift	VERB
gs-4321	452	21	toward	toward	ADP
gs-4321	452	22	more	more	ADV
gs-4321	452	23	aggressive	aggressive	ADJ
gs-4321	452	24	states	state	NOUN
gs-4321	452	25	under	under	ADP
gs-4321	452	26	selective	selective	ADJ
gs-4321	452	27	pressure	pressure	NOUN
gs-4321	452	28	.	.	PUNCT
gs-4321	453	1	moreover	moreover	ADV
gs-4321	453	2	,	,	PUNCT
gs-4321	453	3	variability	variability	NOUN
gs-4321	453	4	in	in	ADP
gs-4321	453	5	stemness	stemness	ADJ
gs-4321	453	6	scores	score	NOUN
gs-4321	453	7	within	within	ADP
gs-4321	453	8	the	the	DET
gs-4321	453	9	stem	stem	NOUN
gs-4321	453	10	-	-	PUNCT
gs-4321	453	11	like	like	ADJ
gs-4321	453	12	compartment	compartment	NOUN
gs-4321	453	13	itself	itself	PRON
gs-4321	453	14	indicates	indicate	VERB
gs-4321	453	15	that	that	SCONJ
gs-4321	453	16	even	even	ADV
gs-4321	453	17	highly	highly	ADV
gs-4321	453	18	plastic	plastic	ADJ
gs-4321	453	19	cells	cell	NOUN
gs-4321	453	20	exist	exist	VERB
gs-4321	453	21	along	along	ADP
gs-4321	453	22	subgradients	subgradient	NOUN
gs-4321	453	23	of	of	ADP
gs-4321	453	24	potency	potency	NOUN
gs-4321	453	25	,	,	PUNCT
gs-4321	453	26	potentially	potentially	ADV
gs-4321	453	27	reflecting	reflect	VERB
gs-4321	453	28	differential	differential	ADJ
gs-4321	453	29	exposure	exposure	NOUN
gs-4321	453	30	to	to	ADP
gs-4321	453	31	niche	niche	NOUN
gs-4321	453	32	-	-	PUNCT
gs-4321	453	33	derived	derive	VERB
gs-4321	453	34	cues	cue	NOUN
gs-4321	453	35	such	such	ADJ
gs-4321	453	36	as	as	ADP
gs-4321	453	37	hypoxia	hypoxia	NOUN
gs-4321	453	38	,	,	PUNCT
gs-4321	453	39	cytokine	cytokine	ADJ
gs-4321	453	40	signaling	signal	VERB
gs-4321	453	41	,	,	PUNCT
gs-4321	453	42	or	or	CCONJ
gs-4321	453	43	metabolic	metabolic	NOUN
gs-4321	453	44	stress	stress	NOUN
gs-4321	453	45	.	.	PUNCT
gs-4321	454	1	a	a	DET
gs-4321	454	2	deeper	deep	ADJ
gs-4321	454	3	investigation	investigation	NOUN
gs-4321	454	4	into	into	ADP
gs-4321	454	5	regulatory	regulatory	ADJ
gs-4321	454	6	circuits	circuit	NOUN
gs-4321	454	7	highlighted	highlight	VERB
gs-4321	454	8	that	that	SCONJ
gs-4321	454	9	the	the	DET
gs-4321	454	10	coordinated	coordinated	ADJ
gs-4321	454	11	behavior	behavior	NOUN
gs-4321	454	12	of	of	ADP
gs-4321	454	13	sox2	sox2	PROPN
gs-4321	454	14	,	,	PUNCT
gs-4321	454	15	jun	jun	PROPN
gs-4321	454	16	,	,	PUNCT
gs-4321	454	17	mitf	mitf	NOUN
gs-4321	454	18	,	,	PUNCT
gs-4321	454	19	and	and	CCONJ
gs-4321	454	20	zeb1	zeb1	PROPN
gs-4321	454	21	does	do	AUX
gs-4321	454	22	not	not	PART
gs-4321	454	23	operate	operate	VERB
gs-4321	454	24	in	in	ADP
gs-4321	454	25	isolation	isolation	NOUN
gs-4321	454	26	but	but	CCONJ
gs-4321	454	27	interacts	interact	VERB
gs-4321	454	28	with	with	ADP
gs-4321	454	29	broader	broad	ADJ
gs-4321	454	30	transcriptional	transcriptional	ADJ
gs-4321	454	31	modules	module	NOUN
gs-4321	454	32	that	that	PRON
gs-4321	454	33	govern	govern	VERB
gs-4321	454	34	proliferation	proliferation	NOUN
gs-4321	454	35	,	,	PUNCT
gs-4321	454	36	survival	survival	NOUN
gs-4321	454	37	,	,	PUNCT
gs-4321	454	38	and	and	CCONJ
gs-4321	454	39	epigenetic	epigenetic	ADJ
gs-4321	454	40	remodeling	remodeling	NOUN
gs-4321	454	41	.	.	PUNCT
gs-4321	455	1	coexpression	coexpression	NOUN
gs-4321	455	2	network	network	NOUN
gs-4321	455	3	analysis	analysis	NOUN
gs-4321	455	4	demonstrated	demonstrate	VERB
gs-4321	455	5	that	that	SCONJ
gs-4321	455	6	sox2	sox2	NOUN
gs-4321	455	7	-	-	PUNCT
gs-4321	455	8	high	high	ADJ
gs-4321	455	9	stem	stem	NOUN
gs-4321	455	10	-	-	PUNCT
gs-4321	455	11	like	like	ADJ
gs-4321	455	12	cells	cell	NOUN
gs-4321	455	13	exhibit	exhibit	VERB
gs-4321	455	14	upregulation	upregulation	NOUN
gs-4321	455	15	of	of	ADP
gs-4321	455	16	chromatin	chromatin	NOUN
gs-4321	455	17	-	-	PUNCT
gs-4321	455	18	remodeling	remodel	VERB
gs-4321	455	19	factors	factor	NOUN
gs-4321	455	20	and	and	CCONJ
gs-4321	455	21	developmental	developmental	ADJ
gs-4321	455	22	pathway	pathway	NOUN
gs-4321	455	23	components	component	NOUN
gs-4321	455	24	,	,	PUNCT
gs-4321	455	25	supporting	support	VERB
gs-4321	455	26	a	a	DET
gs-4321	455	27	model	model	NOUN
gs-4321	455	28	in	in	ADP
gs-4321	455	29	which	which	PRON
gs-4321	455	30	epigenetic	epigenetic	ADJ
gs-4321	455	31	flexibility	flexibility	NOUN
gs-4321	455	32	facilitates	facilitate	VERB
gs-4321	455	33	phenotypic	phenotypic	ADJ
gs-4321	455	34	transitions	transition	NOUN
gs-4321	455	35	.	.	PUNCT
gs-4321	456	1	conversely	conversely	ADV
gs-4321	456	2	,	,	PUNCT
gs-4321	456	3	jun	jun	PROPN
gs-4321	456	4	-	-	PUNCT
gs-4321	456	5	enriched	enrich	VERB
gs-4321	456	6	intermediate	intermediate	ADJ
gs-4321	456	7	cells	cell	NOUN
gs-4321	456	8	showed	show	VERB
gs-4321	456	9	enhanced	enhanced	ADJ
gs-4321	456	10	stress	stress	NOUN
gs-4321	456	11	-	-	PUNCT
gs-4321	456	12	response	response	NOUN
gs-4321	456	13	signatures	signature	NOUN
gs-4321	456	14	,	,	PUNCT
gs-4321	456	15	reinforcing	reinforce	VERB
gs-4321	456	16	the	the	DET
gs-4321	456	17	concept	concept	NOUN
gs-4321	456	18	that	that	SCONJ
gs-4321	456	19	this	this	DET
gs-4321	456	20	state	state	NOUN
gs-4321	456	21	represents	represent	VERB
gs-4321	456	22	an	an	DET
gs-4321	456	23	adaptive	adaptive	ADJ
gs-4321	456	24	interface	interface	NOUN
gs-4321	456	25	enabling	enable	VERB
gs-4321	456	26	tumors	tumor	NOUN
gs-4321	456	27	to	to	PART
gs-4321	456	28	withstand	withstand	VERB
gs-4321	456	29	therapeutic	therapeutic	ADJ
gs-4321	456	30	and	and	CCONJ
gs-4321	456	31	environmental	environmental	ADJ
gs-4321	456	32	challenges	challenge	NOUN
gs-4321	456	33	.	.	PUNCT
gs-4321	457	1	collectively	collectively	ADV
gs-4321	457	2	,	,	PUNCT
gs-4321	457	3	these	these	DET
gs-4321	457	4	extended	extend	VERB
gs-4321	457	5	analyses	analysis	NOUN
gs-4321	457	6	further	far	ADV
gs-4321	457	7	substantiate	substantiate	VERB
gs-4321	457	8	the	the	DET
gs-4321	457	9	presence	presence	NOUN
gs-4321	457	10	of	of	ADP
gs-4321	457	11	a	a	DET
gs-4321	457	12	dynamic	dynamic	ADJ
gs-4321	457	13	,	,	PUNCT
gs-4321	457	14	gradient	gradient	NOUN
gs-4321	457	15	-	-	PUNCT
gs-4321	457	16	driven	drive	VERB
gs-4321	457	17	malignant	malignant	ADJ
gs-4321	457	18	cell	cell	NOUN
gs-4321	457	19	ecosystem	ecosystem	NOUN
gs-4321	457	20	in	in	ADP
gs-4321	457	21	which	which	PRON
gs-4321	457	22	transcriptional	transcriptional	ADJ
gs-4321	457	23	plasticity	plasticity	NOUN
gs-4321	457	24	and	and	CCONJ
gs-4321	457	25	regulatory	regulatory	ADJ
gs-4321	457	26	interplay	interplay	NOUN
gs-4321	457	27	determine	determine	VERB
gs-4321	457	28	the	the	DET
gs-4321	457	29	trajectory	trajectory	NOUN
gs-4321	457	30	toward	toward	ADP
gs-4321	457	31	stem	stem	NOUN
gs-4321	457	32	-	-	PUNCT
gs-4321	457	33	like	like	ADJ
gs-4321	457	34	,	,	PUNCT
gs-4321	457	35	therapy	therapy	NOUN
gs-4321	457	36	-	-	PUNCT
gs-4321	457	37	resistant	resistant	ADJ
gs-4321	457	38	phenotypes	phenotype	NOUN
gs-4321	457	39	.	.	PUNCT
gs-4321	458	1	additional	additional	ADJ
gs-4321	458	2	multimodal	multimodal	NOUN
gs-4321	458	3	integration	integration	NOUN
gs-4321	458	4	further	far	ADV
gs-4321	458	5	strengthened	strengthen	VERB
gs-4321	458	6	the	the	DET
gs-4321	458	7	characterization	characterization	NOUN
gs-4321	458	8	of	of	ADP
gs-4321	458	9	malignant	malignant	ADJ
gs-4321	458	10	cell	cell	NOUN
gs-4321	458	11	states	state	NOUN
gs-4321	458	12	and	and	CCONJ
gs-4321	458	13	revealed	reveal	VERB
gs-4321	458	14	deeper	deep	ADJ
gs-4321	458	15	layers	layer	NOUN
gs-4321	458	16	of	of	ADP
gs-4321	458	17	biological	biological	ADJ
gs-4321	458	18	complexity	complexity	NOUN
gs-4321	458	19	that	that	PRON
gs-4321	458	20	shape	shape	VERB
gs-4321	458	21	their	their	PRON
gs-4321	458	22	adaptive	adaptive	ADJ
gs-4321	458	23	behaviors	behavior	NOUN
gs-4321	458	24	.	.	PUNCT
gs-4321	459	1	when	when	SCONJ
gs-4321	459	2	signaling	signal	VERB
gs-4321	459	3	pathway	pathway	NOUN
gs-4321	459	4	activities	activity	NOUN
gs-4321	459	5	were	be	AUX
gs-4321	459	6	projected	project	VERB
gs-4321	459	7	onto	onto	ADP
gs-4321	459	8	the	the	DET
gs-4321	459	9	same	same	ADJ
gs-4321	459	10	umap	umap	NOUN
gs-4321	459	11	embedding	embed	VERB
gs-4321	459	12	,	,	PUNCT
gs-4321	459	13	differentiated	differentiated	ADJ
gs-4321	459	14	cells	cell	NOUN
gs-4321	459	15	exhibited	exhibit	VERB
gs-4321	459	16	enrichment	enrichment	NOUN
gs-4321	459	17	of	of	ADP
gs-4321	459	18	pathways	pathway	NOUN
gs-4321	459	19	associated	associate	VERB
gs-4321	459	20	with	with	ADP
gs-4321	459	21	cellular	cellular	ADJ
gs-4321	459	22	homeostasis	homeostasis	NOUN
gs-4321	459	23	,	,	PUNCT
gs-4321	459	24	pigment	pigment	NOUN
gs-4321	459	25	production	production	NOUN
gs-4321	459	26	,	,	PUNCT
gs-4321	459	27	and	and	CCONJ
gs-4321	459	28	structural	structural	ADJ
gs-4321	459	29	integrity	integrity	NOUN
gs-4321	459	30	.	.	PUNCT
gs-4321	460	1	in	in	ADP
gs-4321	460	2	contrast	contrast	NOUN
gs-4321	460	3	,	,	PUNCT
gs-4321	460	4	intermediate	intermediate	ADJ
gs-4321	460	5	cells	cell	NOUN
gs-4321	460	6	georgian	georgian	VERB
gs-4321	460	7	scientists/	scientists/	NUM
gs-4321	460	8	.	.	PUNCT
gs-4321	461	1	7	7	NUM
gs-4321	461	2	n	n	DET
gs-4321	461	3	4	4	NUM
gs-4321	461	4	,	,	PUNCT
gs-4321	461	5	2025	2025	NUM
gs-4321	461	6	361	361	NUM
gs-4321	461	7	displayed	display	VERB
gs-4321	461	8	heterogeneous	heterogeneous	ADJ
gs-4321	461	9	activation	activation	NOUN
gs-4321	461	10	patterns	pattern	NOUN
gs-4321	461	11	involving	involve	VERB
gs-4321	461	12	mapk	mapk	NOUN
gs-4321	461	13	,	,	PUNCT
gs-4321	461	14	ap-1	ap-1	ADV
gs-4321	461	15	–	–	PUNCT
gs-4321	461	16	driven	drive	VERB
gs-4321	461	17	stress	stress	NOUN
gs-4321	461	18	responses	response	NOUN
gs-4321	461	19	,	,	PUNCT
gs-4321	461	20	and	and	CCONJ
gs-4321	461	21	partial	partial	ADJ
gs-4321	461	22	emt	emt	PROPN
gs-4321	461	23	signaling	signaling	NOUN
gs-4321	461	24	,	,	PUNCT
gs-4321	461	25	suggesting	suggest	VERB
gs-4321	461	26	that	that	SCONJ
gs-4321	461	27	this	this	DET
gs-4321	461	28	transitional	transitional	ADJ
gs-4321	461	29	population	population	NOUN
gs-4321	461	30	represents	represent	VERB
gs-4321	461	31	a	a	DET
gs-4321	461	32	functionally	functionally	ADV
gs-4321	461	33	versatile	versatile	ADJ
gs-4321	461	34	state	state	NOUN
gs-4321	461	35	equipped	equip	VERB
gs-4321	461	36	to	to	PART
gs-4321	461	37	sense	sense	VERB
gs-4321	461	38	and	and	CCONJ
gs-4321	461	39	respond	respond	VERB
gs-4321	461	40	to	to	ADP
gs-4321	461	41	fluctuating	fluctuate	VERB
gs-4321	461	42	environmental	environmental	ADJ
gs-4321	461	43	pressures	pressure	NOUN
gs-4321	461	44	.	.	PUNCT
gs-4321	462	1	stem	stem	NOUN
gs-4321	462	2	-	-	PUNCT
gs-4321	462	3	like	like	ADJ
gs-4321	462	4	cells	cell	NOUN
gs-4321	462	5	showed	show	VERB
gs-4321	462	6	dominant	dominant	ADJ
gs-4321	462	7	activation	activation	NOUN
gs-4321	462	8	of	of	ADP
gs-4321	462	9	stemness	stemness	NOUN
gs-4321	462	10	-	-	PUNCT
gs-4321	462	11	associated	associate	VERB
gs-4321	462	12	pathways	pathway	NOUN
gs-4321	462	13	,	,	PUNCT
gs-4321	462	14	including	include	VERB
gs-4321	462	15	notch	notch	NOUN
gs-4321	462	16	,	,	PUNCT
gs-4321	462	17	wnt/	wnt/	NOUN
gs-4321	462	18	-catenin	-catenin	ADJ
gs-4321	462	19	,	,	PUNCT
gs-4321	462	20	and	and	CCONJ
gs-4321	462	21	sox2	sox2	NOUN
gs-4321	462	22	-	-	PUNCT
gs-4321	462	23	regulated	regulate	VERB
gs-4321	462	24	modules	module	NOUN
gs-4321	462	25	,	,	PUNCT
gs-4321	462	26	underscoring	underscore	VERB
gs-4321	462	27	their	their	PRON
gs-4321	462	28	enhanced	enhance	VERB
gs-4321	462	29	capacity	capacity	NOUN
gs-4321	462	30	for	for	ADP
gs-4321	462	31	self	self	NOUN
gs-4321	462	32	-	-	PUNCT
gs-4321	462	33	renewal	renewal	NOUN
gs-4321	462	34	and	and	CCONJ
gs-4321	462	35	niche	niche	NOUN
gs-4321	462	36	-	-	ADJ
gs-4321	462	37	independent	independent	ADJ
gs-4321	462	38	survival	survival	NOUN
gs-4321	462	39	.	.	PUNCT
gs-4321	463	1	trajectory	trajectory	NOUN
gs-4321	463	2	inference	inference	PROPN
gs-4321	463	3	performed	perform	VERB
gs-4321	463	4	at	at	ADP
gs-4321	463	5	higher	high	ADJ
gs-4321	463	6	resolution	resolution	NOUN
gs-4321	463	7	identified	identify	VERB
gs-4321	463	8	multiple	multiple	ADJ
gs-4321	463	9	branching	branching	NOUN
gs-4321	463	10	points	point	NOUN
gs-4321	463	11	along	along	ADP
gs-4321	463	12	the	the	DET
gs-4321	463	13	transition	transition	NOUN
gs-4321	463	14	continuum	continuum	ADJ
gs-4321	463	15	.	.	PUNCT
gs-4321	464	1	each	each	DET
gs-4321	464	2	branch	branch	NOUN
gs-4321	464	3	corresponded	correspond	VERB
gs-4321	464	4	to	to	PART
gs-4321	464	5	distinct	distinct	VERB
gs-4321	464	6	regulatory	regulatory	ADJ
gs-4321	464	7	decisions	decision	NOUN
gs-4321	464	8	that	that	PRON
gs-4321	464	9	guided	guide	VERB
gs-4321	464	10	malignant	malignant	ADJ
gs-4321	464	11	cells	cell	NOUN
gs-4321	464	12	toward	toward	ADP
gs-4321	464	13	alternative	alternative	ADJ
gs-4321	464	14	adaptive	adaptive	ADJ
gs-4321	464	15	programs	program	NOUN
gs-4321	464	16	.	.	PUNCT
gs-4321	465	1	one	one	NUM
gs-4321	465	2	major	major	ADJ
gs-4321	465	3	branch	branch	NOUN
gs-4321	465	4	directed	direct	VERB
gs-4321	465	5	cells	cell	NOUN
gs-4321	465	6	toward	toward	ADP
gs-4321	465	7	a	a	DET
gs-4321	465	8	stress	stress	NOUN
gs-4321	465	9	-	-	PUNCT
gs-4321	465	10	adapted	adapt	VERB
gs-4321	465	11	intermediate	intermediate	ADJ
gs-4321	465	12	subtype	subtype	NOUN
gs-4321	465	13	characterized	characterize	VERB
gs-4321	465	14	by	by	ADP
gs-4321	465	15	elevated	elevated	ADJ
gs-4321	465	16	jun	jun	PROPN
gs-4321	465	17	activity	activity	NOUN
gs-4321	465	18	and	and	CCONJ
gs-4321	465	19	metabolic	metabolic	NOUN
gs-4321	465	20	rewiring	rewiring	NOUN
gs-4321	465	21	,	,	PUNCT
gs-4321	465	22	while	while	SCONJ
gs-4321	465	23	another	another	DET
gs-4321	465	24	branch	branch	NOUN
gs-4321	465	25	funneled	funnel	VERB
gs-4321	465	26	cells	cell	NOUN
gs-4321	465	27	toward	toward	ADP
gs-4321	465	28	a	a	DET
gs-4321	465	29	highly	highly	ADV
gs-4321	465	30	plastic	plastic	ADJ
gs-4321	465	31	stem	stem	NOUN
gs-4321	465	32	-	-	PUNCT
gs-4321	465	33	like	like	ADJ
gs-4321	465	34	phenotype	phenotype	NOUN
gs-4321	465	35	with	with	ADP
gs-4321	465	36	robust	robust	ADJ
gs-4321	465	37	sox2	sox2	NOUN
gs-4321	465	38	and	and	CCONJ
gs-4321	465	39	zeb1	zeb1	NOUN
gs-4321	465	40	activation	activation	NOUN
gs-4321	465	41	.	.	PUNCT
gs-4321	466	1	these	these	DET
gs-4321	466	2	findings	finding	NOUN
gs-4321	466	3	highlight	highlight	VERB
gs-4321	466	4	that	that	PRON
gs-4321	466	5	malignant	malignant	ADJ
gs-4321	466	6	progression	progression	NOUN
gs-4321	466	7	does	do	AUX
gs-4321	466	8	not	not	PART
gs-4321	466	9	follow	follow	VERB
gs-4321	466	10	a	a	DET
gs-4321	466	11	single	single	ADJ
gs-4321	466	12	linear	linear	NOUN
gs-4321	466	13	path	path	NOUN
gs-4321	466	14	but	but	CCONJ
gs-4321	466	15	instead	instead	ADV
gs-4321	466	16	encompasses	encompass	VERB
gs-4321	466	17	a	a	DET
gs-4321	466	18	landscape	landscape	NOUN
gs-4321	466	19	of	of	ADP
gs-4321	466	20	possible	possible	ADJ
gs-4321	466	21	trajectories	trajectory	NOUN
gs-4321	466	22	shaped	shape	VERB
gs-4321	466	23	by	by	ADP
gs-4321	466	24	regulatory	regulatory	ADJ
gs-4321	466	25	,	,	PUNCT
gs-4321	466	26	metabolic	metabolic	NOUN
gs-4321	466	27	,	,	PUNCT
gs-4321	466	28	and	and	CCONJ
gs-4321	466	29	microenvironmental	microenvironmental	ADJ
gs-4321	466	30	cues	cue	NOUN
gs-4321	466	31	.	.	PUNCT
gs-4321	467	1	single	single	ADJ
gs-4321	467	2	-	-	PUNCT
gs-4321	467	3	cell	cell	NOUN
gs-4321	467	4	variability	variability	NOUN
gs-4321	467	5	analysis	analysis	NOUN
gs-4321	467	6	revealed	reveal	VERB
gs-4321	467	7	that	that	SCONJ
gs-4321	467	8	within	within	ADP
gs-4321	467	9	each	each	DET
gs-4321	467	10	transcriptionally	transcriptionally	ADV
gs-4321	467	11	defined	define	VERB
gs-4321	467	12	state	state	NOUN
gs-4321	467	13	,	,	PUNCT
gs-4321	467	14	malignant	malignant	ADJ
gs-4321	467	15	cells	cell	NOUN
gs-4321	467	16	exhibited	exhibit	VERB
gs-4321	467	17	distinct	distinct	ADJ
gs-4321	467	18	cell	cell	NOUN
gs-4321	467	19	-	-	PUNCT
gs-4321	467	20	cycle	cycle	NOUN
gs-4321	467	21	distributions	distribution	NOUN
gs-4321	467	22	and	and	CCONJ
gs-4321	467	23	proliferative	proliferative	ADJ
gs-4321	467	24	capacities	capacity	NOUN
gs-4321	467	25	.	.	PUNCT
gs-4321	468	1	differentiated	differentiated	ADJ
gs-4321	468	2	cells	cell	NOUN
gs-4321	468	3	predominantly	predominantly	ADV
gs-4321	468	4	occupied	occupy	VERB
gs-4321	468	5	g1	g1	ADJ
gs-4321	468	6	-	-	PUNCT
gs-4321	468	7	phase	phase	NOUN
gs-4321	468	8	states	state	NOUN
gs-4321	468	9	,	,	PUNCT
gs-4321	468	10	reflecting	reflect	VERB
gs-4321	468	11	a	a	DET
gs-4321	468	12	more	more	ADV
gs-4321	468	13	quiescent	quiescent	ADJ
gs-4321	468	14	or	or	CCONJ
gs-4321	468	15	lineage	lineage	NOUN
gs-4321	468	16	-	-	PUNCT
gs-4321	468	17	committed	commit	VERB
gs-4321	468	18	profile	profile	NOUN
gs-4321	468	19	.	.	PUNCT
gs-4321	469	1	intermediate	intermediate	ADJ
gs-4321	469	2	cells	cell	NOUN
gs-4321	469	3	showed	show	VERB
gs-4321	469	4	greater	great	ADJ
gs-4321	469	5	representation	representation	NOUN
gs-4321	469	6	of	of	ADP
gs-4321	469	7	cells	cell	NOUN
gs-4321	469	8	in	in	ADP
gs-4321	469	9	sphase	sphase	NOUN
gs-4321	469	10	and	and	CCONJ
gs-4321	469	11	early	early	ADJ
gs-4321	469	12	g2	g2	PROPN
gs-4321	469	13	/	/	SYM
gs-4321	469	14	m	m	PROPN
gs-4321	469	15	,	,	PUNCT
gs-4321	469	16	indicating	indicate	VERB
gs-4321	469	17	that	that	SCONJ
gs-4321	469	18	these	these	DET
gs-4321	469	19	cells	cell	NOUN
gs-4321	469	20	retain	retain	VERB
gs-4321	469	21	proliferative	proliferative	ADJ
gs-4321	469	22	flexibility	flexibility	NOUN
gs-4321	469	23	.	.	PUNCT
gs-4321	470	1	stem	stem	NOUN
gs-4321	470	2	-	-	PUNCT
gs-4321	470	3	like	like	ADJ
gs-4321	470	4	cells	cell	NOUN
gs-4321	470	5	showed	show	VERB
gs-4321	470	6	marked	mark	VERB
gs-4321	470	7	enrichment	enrichment	NOUN
gs-4321	470	8	in	in	ADP
gs-4321	470	9	cycling	cycling	NOUN
gs-4321	470	10	states	state	NOUN
gs-4321	470	11	,	,	PUNCT
gs-4321	470	12	consistent	consistent	ADJ
gs-4321	470	13	with	with	ADP
gs-4321	470	14	the	the	DET
gs-4321	470	15	proliferative	proliferative	ADJ
gs-4321	470	16	and	and	CCONJ
gs-4321	470	17	regenerative	regenerative	ADJ
gs-4321	470	18	capacities	capacity	NOUN
gs-4321	470	19	associated	associate	VERB
gs-4321	470	20	with	with	ADP
gs-4321	470	21	high	high	ADJ
gs-4321	470	22	-	-	PUNCT
gs-4321	470	23	plasticity	plasticity	NOUN
gs-4321	470	24	phenotypes	phenotype	NOUN
gs-4321	470	25	.	.	PUNCT
gs-4321	471	1	these	these	DET
gs-4321	471	2	proliferative	proliferative	ADJ
gs-4321	471	3	differences	difference	NOUN
gs-4321	471	4	further	far	ADV
gs-4321	471	5	reinforce	reinforce	VERB
gs-4321	471	6	the	the	DET
gs-4321	471	7	notion	notion	NOUN
gs-4321	471	8	that	that	SCONJ
gs-4321	471	9	malignant	malignant	ADJ
gs-4321	471	10	states	state	NOUN
gs-4321	471	11	reflect	reflect	VERB
gs-4321	471	12	both	both	CCONJ
gs-4321	471	13	functional	functional	ADJ
gs-4321	471	14	and	and	CCONJ
gs-4321	471	15	regulatory	regulatory	ADJ
gs-4321	471	16	diversity	diversity	NOUN
gs-4321	471	17	.	.	PUNCT
gs-4321	472	1	integration	integration	NOUN
gs-4321	472	2	of	of	ADP
gs-4321	472	3	regulatory	regulatory	ADJ
gs-4321	472	4	factor	factor	NOUN
gs-4321	472	5	activity	activity	NOUN
gs-4321	472	6	with	with	ADP
gs-4321	472	7	pseudotime	pseudotime	ADJ
gs-4321	472	8	ordering	ordering	NOUN
gs-4321	472	9	revealed	reveal	VERB
gs-4321	472	10	that	that	SCONJ
gs-4321	472	11	the	the	DET
gs-4321	472	12	coordinated	coordinated	ADJ
gs-4321	472	13	upregulation	upregulation	NOUN
gs-4321	472	14	of	of	ADP
gs-4321	472	15	sox2	sox2	NOUN
gs-4321	472	16	,	,	PUNCT
gs-4321	472	17	zeb1	zeb1	PROPN
gs-4321	472	18	,	,	PUNCT
gs-4321	472	19	and	and	CCONJ
gs-4321	472	20	jun	jun	PROPN
gs-4321	472	21	occurred	occur	VERB
gs-4321	472	22	progressively	progressively	ADV
gs-4321	472	23	along	along	ADP
gs-4321	472	24	the	the	DET
gs-4321	472	25	inferred	infer	VERB
gs-4321	472	26	trajectory	trajectory	NOUN
gs-4321	472	27	toward	toward	ADP
gs-4321	472	28	stem	stem	NOUN
gs-4321	472	29	-	-	PUNCT
gs-4321	472	30	like	like	ADJ
gs-4321	472	31	fates	fate	NOUN
gs-4321	472	32	.	.	PUNCT
gs-4321	473	1	interestingly	interestingly	ADV
gs-4321	473	2	,	,	PUNCT
gs-4321	473	3	mitf	mitf	PROPN
gs-4321	473	4	showed	show	VERB
gs-4321	473	5	context	context	NOUN
gs-4321	473	6	-	-	PUNCT
gs-4321	473	7	dependent	dependent	ADJ
gs-4321	473	8	fluctuations	fluctuation	NOUN
gs-4321	473	9	that	that	PRON
gs-4321	473	10	mirrored	mirror	VERB
gs-4321	473	11	changes	change	NOUN
gs-4321	473	12	in	in	ADP
gs-4321	473	13	chromatin	chromatin	NOUN
gs-4321	473	14	accessibility	accessibility	NOUN
gs-4321	473	15	,	,	PUNCT
gs-4321	473	16	suggesting	suggest	VERB
gs-4321	473	17	that	that	SCONJ
gs-4321	473	18	transcriptional	transcriptional	ADJ
gs-4321	473	19	shifts	shift	NOUN
gs-4321	473	20	in	in	ADP
gs-4321	473	21	mitf	mitf	NOUN
gs-4321	473	22	may	may	AUX
gs-4321	473	23	serve	serve	VERB
gs-4321	473	24	as	as	ADP
gs-4321	473	25	checkpoints	checkpoint	NOUN
gs-4321	473	26	controlling	control	VERB
gs-4321	473	27	the	the	DET
gs-4321	473	28	balance	balance	NOUN
gs-4321	473	29	between	between	ADP
gs-4321	473	30	differentiation	differentiation	NOUN
gs-4321	473	31	and	and	CCONJ
gs-4321	473	32	dedifferentiation	dedifferentiation	NOUN
gs-4321	473	33	.	.	PUNCT
gs-4321	474	1	these	these	DET
gs-4321	474	2	temporally	temporally	ADV
gs-4321	474	3	ordered	order	VERB
gs-4321	474	4	changes	change	NOUN
gs-4321	474	5	imply	imply	VERB
gs-4321	474	6	that	that	SCONJ
gs-4321	474	7	regulatory	regulatory	ADJ
gs-4321	474	8	reprogramming	reprogramming	NOUN
gs-4321	474	9	is	be	AUX
gs-4321	474	10	not	not	PART
gs-4321	474	11	abrupt	abrupt	ADJ
gs-4321	474	12	but	but	CCONJ
gs-4321	474	13	unfolds	unfold	VERB
gs-4321	474	14	through	through	ADP
gs-4321	474	15	tightly	tightly	ADV
gs-4321	474	16	orchestrated	orchestrate	VERB
gs-4321	474	17	,	,	PUNCT
gs-4321	474	18	stepwise	stepwise	ADJ
gs-4321	474	19	transitions	transition	NOUN
gs-4321	474	20	.	.	PUNCT
gs-4321	475	1	together	together	ADV
gs-4321	475	2	,	,	PUNCT
gs-4321	475	3	these	these	DET
gs-4321	475	4	expanded	expand	VERB
gs-4321	475	5	analyses	analysis	NOUN
gs-4321	475	6	provide	provide	VERB
gs-4321	475	7	a	a	DET
gs-4321	475	8	comprehensive	comprehensive	ADJ
gs-4321	475	9	view	view	NOUN
gs-4321	475	10	of	of	ADP
gs-4321	475	11	malignant	malignant	ADJ
gs-4321	475	12	cell	cell	NOUN
gs-4321	475	13	heterogeneity	heterogeneity	NOUN
gs-4321	475	14	,	,	PUNCT
gs-4321	475	15	capturing	capture	VERB
gs-4321	475	16	the	the	DET
gs-4321	475	17	interplay	interplay	NOUN
gs-4321	475	18	between	between	ADP
gs-4321	475	19	transcriptional	transcriptional	ADJ
gs-4321	475	20	states	state	NOUN
gs-4321	475	21	,	,	PUNCT
gs-4321	475	22	proliferative	proliferative	ADJ
gs-4321	475	23	behavior	behavior	NOUN
gs-4321	475	24	,	,	PUNCT
gs-4321	475	25	signaling	signal	VERB
gs-4321	475	26	pathway	pathway	NOUN
gs-4321	475	27	activation	activation	NOUN
gs-4321	475	28	,	,	PUNCT
gs-4321	475	29	and	and	CCONJ
gs-4321	475	30	key	key	ADJ
gs-4321	475	31	regulatory	regulatory	ADJ
gs-4321	475	32	circuits	circuit	NOUN
gs-4321	475	33	.	.	PUNCT
gs-4321	476	1	this	this	DET
gs-4321	476	2	integrative	integrative	ADJ
gs-4321	476	3	framework	framework	NOUN
gs-4321	476	4	demonstrates	demonstrate	VERB
gs-4321	476	5	that	that	SCONJ
gs-4321	476	6	tumor	tumor	NOUN
gs-4321	476	7	plasticity	plasticity	NOUN
gs-4321	476	8	is	be	AUX
gs-4321	476	9	governed	govern	VERB
gs-4321	476	10	by	by	ADP
gs-4321	476	11	multilayered	multilayere	VERB
gs-4321	476	12	and	and	CCONJ
gs-4321	476	13	dynamically	dynamically	ADV
gs-4321	476	14	evolving	evolve	VERB
gs-4321	476	15	processes	process	NOUN
gs-4321	476	16	that	that	PRON
gs-4321	476	17	drive	drive	VERB
gs-4321	476	18	the	the	DET
gs-4321	476	19	emergence	emergence	NOUN
gs-4321	476	20	of	of	ADP
gs-4321	476	21	high	high	ADJ
gs-4321	476	22	-	-	PUNCT
gs-4321	476	23	risk	risk	NOUN
gs-4321	476	24	,	,	PUNCT
gs-4321	476	25	stem	stem	NOUN
gs-4321	476	26	-	-	PUNCT
gs-4321	476	27	like	like	ADJ
gs-4321	476	28	malignant	malignant	ADJ
gs-4321	476	29	phenotypes	phenotype	NOUN
gs-4321	476	30	.	.	PUNCT
gs-4321	477	1	georgian	georgian	NOUN
gs-4321	477	2	scientists/	scientists/	NUM
gs-4321	477	3	.	.	PUNCT
gs-4321	478	1	7	7	NUM
gs-4321	478	2	n	n	DET
gs-4321	478	3	4	4	NUM
gs-4321	478	4	,	,	PUNCT
gs-4321	478	5	2025	2025	NUM
gs-4321	478	6	362	362	NUM
gs-4321	478	7	figure	figure	NOUN
gs-4321	478	8	2	2	NUM
gs-4321	478	9	.	.	PUNCT
gs-4321	478	10	integrated	integrate	VERB
gs-4321	478	11	single	single	ADJ
gs-4321	478	12	-	-	PUNCT
gs-4321	478	13	cell	cell	NOUN
gs-4321	478	14	analysis	analysis	NOUN
gs-4321	478	15	reveals	reveal	VERB
gs-4321	478	16	transcriptional	transcriptional	ADJ
gs-4321	478	17	states	state	NOUN
gs-4321	478	18	,	,	PUNCT
gs-4321	478	19	stemness	stemness	ADJ
gs-4321	478	20	gradients	gradient	NOUN
gs-4321	478	21	,	,	PUNCT
gs-4321	478	22	dynamic	dynamic	ADJ
gs-4321	478	23	transitions	transition	NOUN
gs-4321	478	24	,	,	PUNCT
gs-4321	478	25	and	and	CCONJ
gs-4321	478	26	key	key	ADJ
gs-4321	478	27	regulatory	regulatory	ADJ
gs-4321	478	28	programs	program	NOUN
gs-4321	478	29	in	in	ADP
gs-4321	478	30	malignant	malignant	ADJ
gs-4321	478	31	cells	cell	NOUN
gs-4321	478	32	this	this	DET
gs-4321	478	33	figure	figure	NOUN
gs-4321	478	34	presents	present	VERB
gs-4321	478	35	an	an	DET
gs-4321	478	36	integrated	integrated	ADJ
gs-4321	478	37	overview	overview	NOUN
gs-4321	478	38	of	of	ADP
gs-4321	478	39	the	the	DET
gs-4321	478	40	major	major	ADJ
gs-4321	478	41	analytical	analytical	ADJ
gs-4321	478	42	components	component	NOUN
gs-4321	478	43	used	use	VERB
gs-4321	478	44	to	to	PART
gs-4321	478	45	characterize	characterize	VERB
gs-4321	478	46	adaptive	adaptive	ADJ
gs-4321	478	47	malignant	malignant	ADJ
gs-4321	478	48	cell	cell	NOUN
gs-4321	478	49	states	state	NOUN
gs-4321	478	50	.	.	PUNCT
gs-4321	479	1	(	(	PUNCT
gs-4321	479	2	a)umap	a)umap	ADP
gs-4321	479	3	projection	projection	NOUN
gs-4321	479	4	showing	show	VERB
gs-4321	479	5	the	the	DET
gs-4321	479	6	three	three	NUM
gs-4321	479	7	dominant	dominant	ADJ
gs-4321	479	8	malignant	malignant	ADJ
gs-4321	479	9	states	state	NOUN
gs-4321	479	10	—	—	PUNCT
gs-4321	479	11	differentiated	differentiated	ADJ
gs-4321	479	12	,	,	PUNCT
gs-4321	479	13	intermediate	intermediate	ADJ
gs-4321	479	14	,	,	PUNCT
gs-4321	479	15	and	and	CCONJ
gs-4321	479	16	stem	stem	NOUN
gs-4321	479	17	-	-	PUNCT
gs-4321	479	18	like	like	NOUN
gs-4321	479	19	—	—	PUNCT
gs-4321	479	20	defined	define	VERB
gs-4321	479	21	by	by	ADP
gs-4321	479	22	transcriptional	transcriptional	NOUN
gs-4321	479	23	clustering	clustering	NOUN
gs-4321	479	24	across	across	ADP
gs-4321	479	25	datasets	dataset	NOUN
gs-4321	479	26	.	.	PUNCT
gs-4321	480	1	(	(	PUNCT
gs-4321	480	2	b	b	X
gs-4321	480	3	)	)	PUNCT
gs-4321	480	4	stemness	stemness	ADJ
gs-4321	480	5	score	score	NOUN
gs-4321	480	6	distribution	distribution	NOUN
gs-4321	480	7	across	across	ADP
gs-4321	480	8	the	the	DET
gs-4321	480	9	same	same	ADJ
gs-4321	480	10	embedding	embedding	NOUN
gs-4321	480	11	,	,	PUNCT
gs-4321	480	12	illustrating	illustrate	VERB
gs-4321	480	13	a	a	DET
gs-4321	480	14	continuous	continuous	ADJ
gs-4321	480	15	increase	increase	NOUN
gs-4321	480	16	from	from	ADP
gs-4321	480	17	differentiated	differentiate	VERB
gs-4321	480	18	to	to	ADP
gs-4321	480	19	intermediate	intermediate	ADJ
gs-4321	480	20	and	and	CCONJ
gs-4321	480	21	stem	stem	VERB
gs-4321	480	22	-	-	PUNCT
gs-4321	480	23	like	like	ADJ
gs-4321	480	24	states	state	NOUN
gs-4321	480	25	,	,	PUNCT
gs-4321	480	26	consistent	consistent	ADJ
gs-4321	480	27	with	with	ADP
gs-4321	480	28	gradual	gradual	ADJ
gs-4321	480	29	activation	activation	NOUN
gs-4321	480	30	of	of	ADP
gs-4321	480	31	stem	stem	NOUN
gs-4321	480	32	-	-	PUNCT
gs-4321	480	33	associated	associate	VERB
gs-4321	480	34	programs	program	NOUN
gs-4321	480	35	.	.	PUNCT
gs-4321	481	1	(	(	PUNCT
gs-4321	481	2	c	c	X
gs-4321	481	3	)	)	PUNCT
gs-4321	481	4	streamline	streamline	NOUN
gs-4321	481	5	-	-	PUNCT
gs-4321	481	6	based	base	VERB
gs-4321	481	7	transition	transition	NOUN
gs-4321	481	8	map	map	NOUN
gs-4321	481	9	demonstrating	demonstrate	VERB
gs-4321	481	10	directional	directional	ADJ
gs-4321	481	11	movement	movement	NOUN
gs-4321	481	12	of	of	ADP
gs-4321	481	13	cells	cell	NOUN
gs-4321	481	14	toward	toward	ADP
gs-4321	481	15	intermediate	intermediate	ADJ
gs-4321	481	16	and	and	CCONJ
gs-4321	481	17	stem	stem	NOUN
gs-4321	481	18	-	-	PUNCT
gs-4321	481	19	like	like	ADJ
gs-4321	481	20	regions	region	NOUN
gs-4321	481	21	,	,	PUNCT
gs-4321	481	22	reflecting	reflect	VERB
gs-4321	481	23	progressive	progressive	ADJ
gs-4321	481	24	acquisition	acquisition	NOUN
gs-4321	481	25	of	of	ADP
gs-4321	481	26	adaptive	adaptive	ADJ
gs-4321	481	27	phenotypes	phenotype	NOUN
gs-4321	481	28	.	.	PUNCT
gs-4321	482	1	georgian	georgian	NOUN
gs-4321	482	2	scientists/	scientists/	NUM
gs-4321	482	3	.	.	PUNCT
gs-4321	483	1	7	7	NUM
gs-4321	483	2	n	n	DET
gs-4321	483	3	4	4	NUM
gs-4321	483	4	,	,	PUNCT
gs-4321	483	5	2025	2025	NUM
gs-4321	483	6	363	363	NUM
gs-4321	483	7	(	(	PUNCT
gs-4321	483	8	d	d	NOUN
gs-4321	483	9	)	)	PUNCT
gs-4321	483	10	heatmap	heatmap	NOUN
gs-4321	483	11	of	of	ADP
gs-4321	483	12	four	four	NUM
gs-4321	483	13	key	key	ADJ
gs-4321	483	14	regulatory	regulatory	ADJ
gs-4321	483	15	factors	factor	NOUN
gs-4321	483	16	(	(	PUNCT
gs-4321	483	17	sox2	sox2	PROPN
gs-4321	483	18	,	,	PUNCT
gs-4321	483	19	jun	jun	PROPN
gs-4321	483	20	,	,	PUNCT
gs-4321	483	21	mitf	mitf	NOUN
gs-4321	483	22	,	,	PUNCT
gs-4321	483	23	zeb1	zeb1	PROPN
gs-4321	483	24	)	)	PUNCT
gs-4321	483	25	across	across	ADP
gs-4321	483	26	the	the	DET
gs-4321	483	27	three	three	NUM
gs-4321	483	28	states	state	NOUN
gs-4321	483	29	,	,	PUNCT
gs-4321	483	30	showing	show	VERB
gs-4321	483	31	graded	grade	VERB
gs-4321	483	32	increases	increase	NOUN
gs-4321	483	33	in	in	ADP
gs-4321	483	34	expression	expression	NOUN
gs-4321	483	35	and	and	CCONJ
gs-4321	483	36	activity	activity	NOUN
gs-4321	483	37	corresponding	correspond	VERB
gs-4321	483	38	to	to	ADP
gs-4321	483	39	heightened	heighten	VERB
gs-4321	483	40	cellular	cellular	ADJ
gs-4321	483	41	plasticity	plasticity	NOUN
gs-4321	483	42	.	.	PUNCT
gs-4321	484	1	collectively	collectively	ADV
gs-4321	484	2	,	,	PUNCT
gs-4321	484	3	these	these	DET
gs-4321	484	4	panels	panel	NOUN
gs-4321	484	5	highlight	highlight	VERB
gs-4321	484	6	the	the	DET
gs-4321	484	7	structure	structure	NOUN
gs-4321	484	8	of	of	ADP
gs-4321	484	9	malignant	malignant	ADJ
gs-4321	484	10	cell	cell	NOUN
gs-4321	484	11	heterogeneity	heterogeneity	NOUN
gs-4321	484	12	,	,	PUNCT
gs-4321	484	13	the	the	DET
gs-4321	484	14	directionality	directionality	NOUN
gs-4321	484	15	of	of	ADP
gs-4321	484	16	state	state	NOUN
gs-4321	484	17	transitions	transition	NOUN
gs-4321	484	18	,	,	PUNCT
gs-4321	484	19	and	and	CCONJ
gs-4321	484	20	the	the	DET
gs-4321	484	21	regulatory	regulatory	ADJ
gs-4321	484	22	mechanisms	mechanism	NOUN
gs-4321	484	23	that	that	PRON
gs-4321	484	24	define	define	VERB
gs-4321	484	25	adaptive	adaptive	ADJ
gs-4321	484	26	behavior	behavior	NOUN
gs-4321	484	27	in	in	ADP
gs-4321	484	28	tumor	tumor	NOUN
gs-4321	484	29	ecosystems	ecosystem	NOUN
gs-4321	484	30	.	.	PUNCT
gs-4321	485	1	cell	cell	NOUN
gs-4321	485	2	–	–	PUNCT
gs-4321	485	3	cell	cell	NOUN
gs-4321	485	4	communication	communication	NOUN
gs-4321	485	5	networks	network	NOUN
gs-4321	485	6	drive	drive	VERB
gs-4321	485	7	spatially	spatially	ADV
gs-4321	485	8	organized	organize	VERB
gs-4321	485	9	plasticity	plasticity	NOUN
gs-4321	485	10	in	in	ADP
gs-4321	485	11	the	the	DET
gs-4321	485	12	tumor	tumor	NOUN
gs-4321	485	13	microenvironment	microenvironment	NOUN
gs-4321	485	14	to	to	PART
gs-4321	485	15	comprehensively	comprehensively	ADV
gs-4321	485	16	map	map	VERB
gs-4321	485	17	the	the	DET
gs-4321	485	18	intercellular	intercellular	ADJ
gs-4321	485	19	signaling	signal	VERB
gs-4321	485	20	landscape	landscape	NOUN
gs-4321	485	21	regulating	regulate	VERB
gs-4321	485	22	malignant	malignant	ADJ
gs-4321	485	23	plasticity	plasticity	NOUN
gs-4321	485	24	,	,	PUNCT
gs-4321	485	25	we	we	PRON
gs-4321	485	26	applied	apply	VERB
gs-4321	485	27	computational	computational	ADJ
gs-4321	485	28	communication	communication	NOUN
gs-4321	485	29	inference	inference	NOUN
gs-4321	485	30	tools	tool	NOUN
gs-4321	485	31	to	to	ADP
gs-4321	485	32	integrated	integrate	VERB
gs-4321	485	33	singlecell	singlecell	NOUN
gs-4321	485	34	transcriptomic	transcriptomic	ADJ
gs-4321	485	35	datasets	dataset	NOUN
gs-4321	485	36	from	from	ADP
gs-4321	485	37	lung	lung	NOUN
gs-4321	485	38	,	,	PUNCT
gs-4321	485	39	breast	breast	NOUN
gs-4321	485	40	,	,	PUNCT
gs-4321	485	41	melanoma	melanoma	NOUN
gs-4321	485	42	,	,	PUNCT
gs-4321	485	43	and	and	CCONJ
gs-4321	485	44	colorectal	colorectal	ADJ
gs-4321	485	45	cancers	cancer	NOUN
gs-4321	485	46	.	.	PUNCT
gs-4321	486	1	using	use	VERB
gs-4321	486	2	cellphonedb	cellphonedb	NOUN
gs-4321	486	3	and	and	CCONJ
gs-4321	486	4	nichenet	nichenet	NOUN
gs-4321	486	5	,	,	PUNCT
gs-4321	486	6	we	we	PRON
gs-4321	486	7	reconstructed	reconstruct	VERB
gs-4321	486	8	ligand	ligand	ADJ
gs-4321	486	9	–	–	PUNCT
gs-4321	486	10	receptor	receptor	NOUN
gs-4321	486	11	interaction	interaction	NOUN
gs-4321	486	12	networks	network	NOUN
gs-4321	486	13	linking	link	VERB
gs-4321	486	14	tumor	tumor	NOUN
gs-4321	486	15	cells	cell	NOUN
gs-4321	486	16	with	with	ADP
gs-4321	486	17	stromal	stromal	ADJ
gs-4321	486	18	,	,	PUNCT
gs-4321	486	19	immune	immune	ADJ
gs-4321	486	20	,	,	PUNCT
gs-4321	486	21	and	and	CCONJ
gs-4321	486	22	endothelial	endothelial	ADJ
gs-4321	486	23	populations	population	NOUN
gs-4321	486	24	(	(	PUNCT
gs-4321	486	25	figure	figure	NOUN
gs-4321	486	26	3a	3a	NUM
gs-4321	486	27	)	)	PUNCT
gs-4321	486	28	.	.	PUNCT
gs-4321	487	1	network	network	NOUN
gs-4321	487	2	analysis	analysis	NOUN
gs-4321	487	3	revealed	reveal	VERB
gs-4321	487	4	that	that	SCONJ
gs-4321	487	5	cancer	cancer	NOUN
gs-4321	487	6	stem	stem	NOUN
gs-4321	487	7	cells	cell	NOUN
gs-4321	487	8	(	(	PUNCT
gs-4321	487	9	cscs	cscs	PROPN
gs-4321	487	10	)	)	PUNCT
gs-4321	487	11	and	and	CCONJ
gs-4321	487	12	intermediate	intermediate	ADJ
gs-4321	487	13	-	-	PUNCT
gs-4321	487	14	state	state	NOUN
gs-4321	487	15	malignant	malignant	ADJ
gs-4321	487	16	cells	cell	NOUN
gs-4321	487	17	function	function	VERB
gs-4321	487	18	as	as	ADP
gs-4321	487	19	highly	highly	ADV
gs-4321	487	20	receptive	receptive	ADJ
gs-4321	487	21	nodes	node	NOUN
gs-4321	487	22	,	,	PUNCT
gs-4321	487	23	receiving	receive	VERB
gs-4321	487	24	convergent	convergent	NOUN
gs-4321	487	25	signals	signal	NOUN
gs-4321	487	26	from	from	ADP
gs-4321	487	27	cancerassociated	cancerassociate	VERB
gs-4321	487	28	fibroblasts	fibroblast	NOUN
gs-4321	487	29	(	(	PUNCT
gs-4321	487	30	cafs	cafs	NOUN
gs-4321	487	31	)	)	PUNCT
gs-4321	487	32	,	,	PUNCT
gs-4321	487	33	tumor	tumor	NOUN
gs-4321	487	34	-	-	PUNCT
gs-4321	487	35	associated	associate	VERB
gs-4321	487	36	macrophages	macrophage	NOUN
gs-4321	487	37	(	(	PUNCT
gs-4321	487	38	tams	tam	NOUN
gs-4321	487	39	)	)	PUNCT
gs-4321	487	40	,	,	PUNCT
gs-4321	487	41	and	and	CCONJ
gs-4321	487	42	endothelial	endothelial	ADJ
gs-4321	487	43	cells	cell	NOUN
gs-4321	487	44	.	.	PUNCT
gs-4321	488	1	key	key	ADJ
gs-4321	488	2	plasticity	plasticity	NOUN
gs-4321	488	3	-	-	PUNCT
gs-4321	488	4	promoting	promote	VERB
gs-4321	488	5	pathways	pathway	NOUN
gs-4321	488	6	included	include	VERB
gs-4321	488	7	tgf	tgf	PROPN
gs-4321	488	8	(	(	PUNCT
gs-4321	488	9	mediating	mediate	VERB
gs-4321	488	10	epithelial	epithelial	ADJ
gs-4321	488	11	-	-	PUNCT
gs-4321	488	12	mesenchymal	mesenchymal	NOUN
gs-4321	488	13	transition	transition	NOUN
gs-4321	488	14	and	and	CCONJ
gs-4321	488	15	stemness	stemness	ADJ
gs-4321	488	16	maintenance	maintenance	NOUN
gs-4321	488	17	)	)	PUNCT
gs-4321	488	18	,	,	PUNCT
gs-4321	488	19	il-6	il-6	NOUN
gs-4321	488	20	/	/	SYM
gs-4321	488	21	stat3	stat3	NOUN
gs-4321	488	22	(	(	PUNCT
gs-4321	488	23	driving	drive	VERB
gs-4321	488	24	inflammatory	inflammatory	ADJ
gs-4321	488	25	reprogramming	reprogramme	VERB
gs-4321	488	26	georgian	georgian	NOUN
gs-4321	488	27	scientists/	scientists/	NUM
gs-4321	488	28	.	.	PUNCT
gs-4321	489	1	7	7	NUM
gs-4321	489	2	n	n	DET
gs-4321	489	3	4	4	NUM
gs-4321	489	4	,	,	PUNCT
gs-4321	489	5	2025	2025	NUM
gs-4321	489	6	364	364	NUM
gs-4321	489	7	and	and	CCONJ
gs-4321	489	8	stress	stress	NOUN
gs-4321	489	9	adaptation	adaptation	NOUN
gs-4321	489	10	)	)	PUNCT
gs-4321	490	1	,	,	PUNCT
gs-4321	490	2	cxcl12	cxcl12	ADJ
gs-4321	490	3	/	/	SYM
gs-4321	490	4	cxcr4	cxcr4	NOUN
gs-4321	490	5	(	(	PUNCT
gs-4321	490	6	supporting	support	VERB
gs-4321	490	7	niche	niche	NOUN
gs-4321	490	8	retention	retention	NOUN
gs-4321	490	9	and	and	CCONJ
gs-4321	490	10	survival	survival	NOUN
gs-4321	490	11	)	)	PUNCT
gs-4321	490	12	,	,	PUNCT
gs-4321	490	13	wnt	wnt	PROPN
gs-4321	490	14	ligands	ligand	NOUN
gs-4321	490	15	(	(	PUNCT
gs-4321	490	16	activating	activate	VERB
gs-4321	490	17	stem	stem	NOUN
gs-4321	490	18	-	-	PUNCT
gs-4321	490	19	associated	associate	VERB
gs-4321	490	20	transcriptional	transcriptional	NOUN
gs-4321	490	21	programs	program	NOUN
gs-4321	490	22	)	)	PUNCT
gs-4321	490	23	,	,	PUNCT
gs-4321	490	24	and	and	CCONJ
gs-4321	490	25	hgf	hgf	PROPN
gs-4321	490	26	/	/	SYM
gs-4321	490	27	met	meet	VERB
gs-4321	490	28	(	(	PUNCT
gs-4321	490	29	enhancing	enhance	VERB
gs-4321	490	30	motility	motility	NOUN
gs-4321	490	31	and	and	CCONJ
gs-4321	490	32	therapy	therapy	NOUN
gs-4321	490	33	resistance	resistance	NOUN
gs-4321	490	34	)	)	PUNCT
gs-4321	490	35	.	.	PUNCT
gs-4321	491	1	notably	notably	ADV
gs-4321	491	2	,	,	PUNCT
gs-4321	491	3	cafs	cafs	NOUN
gs-4321	491	4	and	and	CCONJ
gs-4321	491	5	tams	tam	NOUN
gs-4321	491	6	emerged	emerge	VERB
gs-4321	491	7	as	as	ADP
gs-4321	491	8	dominant	dominant	ADJ
gs-4321	491	9	signaling	signal	VERB
gs-4321	491	10	sources	source	NOUN
gs-4321	491	11	,	,	PUNCT
gs-4321	491	12	collectively	collectively	ADV
gs-4321	491	13	accounting	account	VERB
gs-4321	491	14	for	for	ADP
gs-4321	491	15	over	over	ADP
gs-4321	491	16	60	60	NUM
gs-4321	491	17	%	%	NOUN
gs-4321	491	18	of	of	ADP
gs-4321	491	19	plasticity	plasticity	NOUN
gs-4321	491	20	-	-	PUNCT
gs-4321	491	21	associated	associate	VERB
gs-4321	491	22	interactions	interaction	NOUN
gs-4321	491	23	targeting	target	VERB
gs-4321	491	24	malignant	malignant	ADJ
gs-4321	491	25	cells	cell	NOUN
gs-4321	491	26	.	.	PUNCT
gs-4321	492	1	to	to	PART
gs-4321	492	2	determine	determine	VERB
gs-4321	492	3	whether	whether	SCONJ
gs-4321	492	4	these	these	DET
gs-4321	492	5	communication	communication	NOUN
gs-4321	492	6	networks	network	NOUN
gs-4321	492	7	exhibit	exhibit	VERB
gs-4321	492	8	spatial	spatial	ADJ
gs-4321	492	9	organization	organization	NOUN
gs-4321	492	10	,	,	PUNCT
gs-4321	492	11	we	we	PRON
gs-4321	492	12	integrated	integrate	VERB
gs-4321	492	13	scrna	scrna	NOUN
gs-4321	492	14	-	-	PUNCT
gs-4321	492	15	seq	seq	NOUN
gs-4321	492	16	annotations	annotation	NOUN
gs-4321	492	17	with	with	ADP
gs-4321	492	18	10x	10x	PROPN
gs-4321	492	19	visium	visium	PROPN
gs-4321	492	20	spatial	spatial	ADJ
gs-4321	492	21	transcriptomics	transcriptomics	PROPN
gs-4321	492	22	data	datum	NOUN
gs-4321	492	23	(	(	PUNCT
gs-4321	492	24	figure	figure	NOUN
gs-4321	492	25	3b	3b	NUM
gs-4321	492	26	)	)	PUNCT
gs-4321	492	27	.	.	PUNCT
gs-4321	493	1	this	this	DET
gs-4321	493	2	analysis	analysis	NOUN
gs-4321	493	3	revealed	reveal	VERB
gs-4321	493	4	functionally	functionally	ADV
gs-4321	493	5	distinct	distinct	ADJ
gs-4321	493	6	microenvironmental	microenvironmental	ADJ
gs-4321	493	7	niches	niche	NOUN
gs-4321	493	8	that	that	PRON
gs-4321	493	9	selectively	selectively	ADV
gs-4321	493	10	harbor	harbor	VERB
gs-4321	493	11	and	and	CCONJ
gs-4321	493	12	regulate	regulate	VERB
gs-4321	493	13	adaptable	adaptable	ADJ
gs-4321	493	14	cell	cell	NOUN
gs-4321	493	15	states	state	NOUN
gs-4321	493	16	.	.	PUNCT
gs-4321	494	1	hypoxic	hypoxic	ADJ
gs-4321	494	2	regions	region	NOUN
gs-4321	494	3	,	,	PUNCT
gs-4321	494	4	characterized	characterize	VERB
gs-4321	494	5	by	by	ADP
gs-4321	494	6	hif1a	hif1a	PROPN
gs-4321	494	7	and	and	CCONJ
gs-4321	494	8	carbonic	carbonic	ADJ
gs-4321	494	9	anhydrase	anhydrase	NOUN
gs-4321	494	10	expression	expression	NOUN
gs-4321	494	11	,	,	PUNCT
gs-4321	494	12	were	be	AUX
gs-4321	494	13	enriched	enrich	VERB
gs-4321	494	14	for	for	ADP
gs-4321	494	15	stem	stem	NOUN
gs-4321	494	16	-	-	PUNCT
gs-4321	494	17	like	like	ADJ
gs-4321	494	18	and	and	CCONJ
gs-4321	494	19	stress	stress	NOUN
gs-4321	494	20	-	-	PUNCT
gs-4321	494	21	responsive	responsive	ADJ
gs-4321	494	22	tumor	tumor	NOUN
gs-4321	494	23	cells	cell	NOUN
gs-4321	494	24	exhibiting	exhibit	VERB
gs-4321	494	25	elevated	elevated	ADJ
gs-4321	494	26	transcriptional	transcriptional	NOUN
gs-4321	494	27	entropy	entropy	NOUN
gs-4321	494	28	.	.	PUNCT
gs-4321	495	1	perivascular	perivascular	ADJ
gs-4321	495	2	niches	niche	NOUN
gs-4321	495	3	,	,	PUNCT
gs-4321	495	4	identified	identify	VERB
gs-4321	495	5	by	by	ADP
gs-4321	495	6	proximity	proximity	NOUN
gs-4321	495	7	to	to	ADP
gs-4321	495	8	pecam1	pecam1	PROPN
gs-4321	495	9	+	+	NUM
gs-4321	495	10	and	and	CCONJ
gs-4321	495	11	vwf+	vwf+	PUNCT
gs-4321	495	12	endothelial	endothelial	ADJ
gs-4321	495	13	structures	structure	NOUN
gs-4321	495	14	,	,	PUNCT
gs-4321	495	15	harbored	harbor	VERB
gs-4321	495	16	quiescent	quiescent	ADJ
gs-4321	495	17	and	and	CCONJ
gs-4321	495	18	therapyresistant	therapyresistant	ADJ
gs-4321	495	19	populations	population	NOUN
gs-4321	495	20	with	with	ADP
gs-4321	495	21	upregulated	upregulated	ADJ
gs-4321	495	22	autophagy	autophagy	NOUN
gs-4321	495	23	and	and	CCONJ
gs-4321	495	24	dna	dna	PROPN
gs-4321	495	25	repair	repair	NOUN
gs-4321	495	26	programs	program	NOUN
gs-4321	495	27	.	.	PUNCT
gs-4321	496	1	immuneinfiltrated	immuneinfiltrate	VERB
gs-4321	496	2	zones	zone	NOUN
gs-4321	496	3	,	,	PUNCT
gs-4321	496	4	marked	mark	VERB
gs-4321	496	5	by	by	ADP
gs-4321	496	6	high	high	ADJ
gs-4321	496	7	densities	density	NOUN
gs-4321	496	8	of	of	ADP
gs-4321	496	9	cd3	cd3	PROPN
gs-4321	496	10	+	+	PROPN
gs-4321	496	11	t	t	NOUN
gs-4321	496	12	cells	cell	NOUN
gs-4321	496	13	and	and	CCONJ
gs-4321	496	14	cd68	cd68	PROPN
gs-4321	496	15	+	+	NUM
gs-4321	496	16	macrophages	macrophage	NOUN
gs-4321	496	17	,	,	PUNCT
gs-4321	496	18	displayed	display	VERB
gs-4321	496	19	elevated	elevate	VERB
gs-4321	496	20	ifn	ifn	PROPN
gs-4321	496	21	–	–	PUNCT
gs-4321	496	22	stat1	stat1	NOUN
gs-4321	496	23	signaling	signaling	NOUN
gs-4321	496	24	,	,	PUNCT
gs-4321	496	25	which	which	PRON
gs-4321	496	26	paradoxically	paradoxically	ADV
gs-4321	496	27	drove	drive	VERB
gs-4321	496	28	dedifferentiation	dedifferentiation	NOUN
gs-4321	496	29	and	and	CCONJ
gs-4321	496	30	immune	immune	ADJ
gs-4321	496	31	evasion	evasion	NOUN
gs-4321	496	32	in	in	ADP
gs-4321	496	33	malignant	malignant	ADJ
gs-4321	496	34	cells	cell	NOUN
gs-4321	496	35	.	.	PUNCT
gs-4321	497	1	stromal	stromal	ADJ
gs-4321	497	2	-	-	PUNCT
gs-4321	497	3	enriched	enrich	VERB
gs-4321	497	4	areas	area	NOUN
gs-4321	497	5	,	,	PUNCT
gs-4321	497	6	dominated	dominate	VERB
gs-4321	497	7	by	by	ADP
gs-4321	497	8	fap+	fap+	PROPN
gs-4321	497	9	and	and	CCONJ
gs-4321	497	10	acta2	acta2	PROPN
gs-4321	497	11	+	+	SYM
gs-4321	497	12	cafs	cafs	NOUN
gs-4321	497	13	,	,	PUNCT
gs-4321	497	14	showed	show	VERB
gs-4321	497	15	enhanced	enhanced	ADJ
gs-4321	497	16	tgf	tgf	PROPN
gs-4321	497	17	and	and	CCONJ
gs-4321	497	18	il-6	il-6	NOUN
gs-4321	497	19	secretion	secretion	NOUN
gs-4321	497	20	,	,	PUNCT
gs-4321	497	21	promoting	promote	VERB
gs-4321	497	22	mesenchymal	mesenchymal	NOUN
gs-4321	497	23	and	and	CCONJ
gs-4321	497	24	stem	stem	NOUN
gs-4321	497	25	-	-	PUNCT
gs-4321	497	26	associated	associate	VERB
gs-4321	497	27	transcriptional	transcriptional	ADJ
gs-4321	497	28	states	state	NOUN
gs-4321	497	29	in	in	ADP
gs-4321	497	30	adjacent	adjacent	ADJ
gs-4321	497	31	tumor	tumor	NOUN
gs-4321	497	32	cells	cell	NOUN
gs-4321	497	33	.	.	PUNCT
gs-4321	498	1	quantification	quantification	NOUN
gs-4321	498	2	of	of	ADP
gs-4321	498	3	communication	communication	NOUN
gs-4321	498	4	strength	strength	NOUN
gs-4321	498	5	between	between	ADP
gs-4321	498	6	cell	cell	NOUN
gs-4321	498	7	type	type	NOUN
gs-4321	498	8	pairs	pair	NOUN
gs-4321	498	9	(	(	PUNCT
gs-4321	498	10	figure	figure	NOUN
gs-4321	498	11	3c	3c	NUM
gs-4321	498	12	)	)	PUNCT
gs-4321	498	13	confirmed	confirm	VERB
gs-4321	498	14	that	that	SCONJ
gs-4321	498	15	cafs	cafs	NOUN
gs-4321	498	16	and	and	CCONJ
gs-4321	498	17	tams	tam	NOUN
gs-4321	498	18	serve	serve	VERB
gs-4321	498	19	as	as	ADP
gs-4321	498	20	the	the	DET
gs-4321	498	21	primary	primary	ADJ
gs-4321	498	22	drivers	driver	NOUN
gs-4321	498	23	of	of	ADP
gs-4321	498	24	intercellular	intercellular	ADJ
gs-4321	498	25	signaling	signal	VERB
gs-4321	498	26	to	to	ADP
gs-4321	498	27	malignant	malignant	ADJ
gs-4321	498	28	populations	population	NOUN
gs-4321	498	29	,	,	PUNCT
gs-4321	498	30	while	while	SCONJ
gs-4321	498	31	cscs	cscs	PROPN
gs-4321	498	32	and	and	CCONJ
gs-4321	498	33	intermediate	intermediate	ADJ
gs-4321	498	34	cells	cell	NOUN
gs-4321	498	35	exhibited	exhibit	VERB
gs-4321	498	36	the	the	DET
gs-4321	498	37	highest	high	ADJ
gs-4321	498	38	receptor	receptor	NOUN
gs-4321	498	39	expression	expression	NOUN
gs-4321	498	40	levels	level	NOUN
gs-4321	498	41	,	,	PUNCT
gs-4321	498	42	consistent	consistent	ADJ
gs-4321	498	43	with	with	ADP
gs-4321	498	44	their	their	PRON
gs-4321	498	45	elevated	elevated	ADJ
gs-4321	498	46	responsiveness	responsiveness	NOUN
gs-4321	498	47	to	to	ADP
gs-4321	498	48	microenvironmental	microenvironmental	ADJ
gs-4321	498	49	cues	cue	NOUN
gs-4321	498	50	.	.	PUNCT
gs-4321	499	1	interestingly	interestingly	ADV
gs-4321	499	2	,	,	PUNCT
gs-4321	499	3	reciprocal	reciprocal	ADJ
gs-4321	499	4	communication	communication	NOUN
gs-4321	499	5	—	—	PUNCT
gs-4321	499	6	where	where	SCONJ
gs-4321	499	7	tumor	tumor	NOUN
gs-4321	499	8	cells	cell	NOUN
gs-4321	499	9	signal	signal	VERB
gs-4321	499	10	back	back	ADV
gs-4321	499	11	to	to	ADP
gs-4321	499	12	stromal	stromal	ADJ
gs-4321	499	13	or	or	CCONJ
gs-4321	499	14	immune	immune	ADJ
gs-4321	499	15	populations	population	NOUN
gs-4321	499	16	—	—	PUNCT
gs-4321	499	17	was	be	AUX
gs-4321	499	18	also	also	ADV
gs-4321	499	19	prevalent	prevalent	ADJ
gs-4321	499	20	,	,	PUNCT
gs-4321	499	21	suggesting	suggest	VERB
gs-4321	499	22	bidirectional	bidirectional	ADJ
gs-4321	499	23	feedback	feedback	NOUN
gs-4321	499	24	loops	loop	NOUN
gs-4321	499	25	that	that	PRON
gs-4321	499	26	stabilize	stabilize	VERB
gs-4321	499	27	adaptive	adaptive	ADJ
gs-4321	499	28	ecosystems	ecosystem	NOUN
gs-4321	499	29	.	.	PUNCT
gs-4321	500	1	to	to	PART
gs-4321	500	2	prioritize	prioritize	VERB
gs-4321	500	3	candidate	candidate	NOUN
gs-4321	500	4	therapeutic	therapeutic	ADJ
gs-4321	500	5	targets	target	NOUN
gs-4321	500	6	,	,	PUNCT
gs-4321	500	7	we	we	PRON
gs-4321	500	8	ranked	rank	VERB
gs-4321	500	9	ligand	ligand	ADJ
gs-4321	500	10	–	–	PUNCT
gs-4321	500	11	receptor	receptor	NOUN
gs-4321	500	12	pairs	pair	NOUN
gs-4321	500	13	by	by	ADP
gs-4321	500	14	their	their	PRON
gs-4321	500	15	association	association	NOUN
gs-4321	500	16	with	with	ADP
gs-4321	500	17	stem	stem	NOUN
gs-4321	500	18	-	-	PUNCT
gs-4321	500	19	like	like	ADJ
gs-4321	500	20	or	or	CCONJ
gs-4321	500	21	therapy	therapy	NOUN
gs-4321	500	22	-	-	PUNCT
gs-4321	500	23	resistant	resistant	ADJ
gs-4321	500	24	state	state	NOUN
gs-4321	500	25	transitions	transition	NOUN
gs-4321	500	26	using	use	VERB
gs-4321	500	27	regulatory	regulatory	ADJ
gs-4321	500	28	potential	potential	ADJ
gs-4321	500	29	analysis	analysis	NOUN
gs-4321	500	30	(	(	PUNCT
gs-4321	500	31	figure	figure	NOUN
gs-4321	500	32	3d	3d	NUM
gs-4321	500	33	)	)	PUNCT
gs-4321	500	34	.	.	PUNCT
gs-4321	501	1	the	the	DET
gs-4321	501	2	top	top	ADV
gs-4321	501	3	-	-	PUNCT
gs-4321	501	4	ranking	rank	VERB
gs-4321	501	5	interactions	interaction	NOUN
gs-4321	501	6	included	include	VERB
gs-4321	501	7	caf	caf	NOUN
gs-4321	501	8	-	-	PUNCT
gs-4321	501	9	derived	derive	VERB
gs-4321	501	10	tgf1	tgf1	NOUN
gs-4321	501	11	binding	bind	VERB
gs-4321	501	12	to	to	PART
gs-4321	501	13	tgfbr1/2	tgfbr1/2	VERB
gs-4321	501	14	on	on	ADP
gs-4321	501	15	tumor	tumor	NOUN
gs-4321	501	16	cells	cell	NOUN
gs-4321	501	17	,	,	PUNCT
gs-4321	501	18	tam	tam	NOUN
gs-4321	501	19	-	-	PUNCT
gs-4321	501	20	secreted	secrete	VERB
gs-4321	501	21	il-6	il-6	NOUN
gs-4321	501	22	activating	activate	VERB
gs-4321	501	23	il6r	il6r	ADJ
gs-4321	501	24	/	/	SYM
gs-4321	501	25	stat3	stat3	NOUN
gs-4321	501	26	pathways	pathway	NOUN
gs-4321	501	27	,	,	PUNCT
gs-4321	501	28	endothelial	endothelial	ADJ
gs-4321	501	29	cxcl12	cxcl12	ADJ
gs-4321	501	30	engaging	engaging	ADJ
gs-4321	501	31	cxcr4	cxcr4	NOUN
gs-4321	501	32	on	on	ADP
gs-4321	501	33	cscs	cscs	PROPN
gs-4321	501	34	,	,	PUNCT
gs-4321	501	35	and	and	CCONJ
gs-4321	501	36	wnt2b	wnt2b	PROPN
gs-4321	501	37	–	–	PUNCT
gs-4321	501	38	fzd	fzd	NOUN
gs-4321	501	39	interactions	interaction	NOUN
gs-4321	501	40	sustaining	sustain	VERB
gs-4321	501	41	self	self	NOUN
gs-4321	501	42	-	-	PUNCT
gs-4321	501	43	renewal	renewal	NOUN
gs-4321	501	44	programs	program	NOUN
gs-4321	501	45	.	.	PUNCT
gs-4321	502	1	pathway	pathway	NOUN
gs-4321	502	2	enrichment	enrichment	NOUN
gs-4321	502	3	analysis	analysis	NOUN
gs-4321	502	4	revealed	reveal	VERB
gs-4321	502	5	that	that	SCONJ
gs-4321	502	6	growth	growth	NOUN
gs-4321	502	7	factors	factor	NOUN
gs-4321	502	8	(	(	PUNCT
gs-4321	502	9	tgf	tgf	PROPN
gs-4321	502	10	,	,	PUNCT
gs-4321	502	11	hgf	hgf	PROPN
gs-4321	502	12	,	,	PUNCT
gs-4321	502	13	egf	egf	PROPN
gs-4321	502	14	)	)	PUNCT
gs-4321	502	15	and	and	CCONJ
gs-4321	502	16	pro	pro	ADJ
gs-4321	502	17	-	-	ADJ
gs-4321	502	18	inflammatory	inflammatory	ADJ
gs-4321	502	19	cytokines	cytokine	NOUN
gs-4321	502	20	(	(	PUNCT
gs-4321	502	21	il-6	il-6	NUM
gs-4321	502	22	,	,	PUNCT
gs-4321	502	23	tnf	tnf	PROPN
gs-4321	502	24	,	,	PUNCT
gs-4321	502	25	il-1	il-1	PUNCT
gs-4321	502	26	)	)	PUNCT
gs-4321	502	27	dominated	dominate	VERB
gs-4321	502	28	the	the	DET
gs-4321	502	29	regulatory	regulatory	ADJ
gs-4321	502	30	landscape	landscape	NOUN
gs-4321	502	31	,	,	PUNCT
gs-4321	502	32	while	while	SCONJ
gs-4321	502	33	chemokines	chemokine	NOUN
gs-4321	502	34	(	(	PUNCT
gs-4321	502	35	cxcl12	cxcl12	ADJ
gs-4321	502	36	,	,	PUNCT
gs-4321	502	37	ccl2	ccl2	PROPN
gs-4321	502	38	)	)	PUNCT
gs-4321	502	39	and	and	CCONJ
gs-4321	502	40	ecm	ecm	PROPN
gs-4321	502	41	components	component	NOUN
gs-4321	502	42	(	(	PUNCT
gs-4321	502	43	fn1	fn1	NOUN
gs-4321	502	44	,	,	PUNCT
gs-4321	502	45	col1a1	col1a1	NOUN
gs-4321	502	46	)	)	PUNCT
gs-4321	502	47	provided	provide	VERB
gs-4321	502	48	structural	structural	ADJ
gs-4321	502	49	and	and	CCONJ
gs-4321	502	50	localization	localization	NOUN
gs-4321	502	51	cues	cue	NOUN
gs-4321	502	52	.	.	PUNCT
gs-4321	503	1	collectively	collectively	ADV
gs-4321	503	2	,	,	PUNCT
gs-4321	503	3	these	these	DET
gs-4321	503	4	findings	finding	NOUN
gs-4321	503	5	demonstrate	demonstrate	VERB
gs-4321	503	6	that	that	SCONJ
gs-4321	503	7	malignant	malignant	ADJ
gs-4321	503	8	plasticity	plasticity	NOUN
gs-4321	503	9	arises	arise	VERB
gs-4321	503	10	from	from	ADP
gs-4321	503	11	coordinated	coordinate	VERB
gs-4321	503	12	multicellular	multicellular	ADJ
gs-4321	503	13	ecosystems	ecosystem	NOUN
gs-4321	503	14	,	,	PUNCT
gs-4321	503	15	where	where	SCONJ
gs-4321	503	16	spatial	spatial	ADJ
gs-4321	503	17	architecture	architecture	NOUN
gs-4321	503	18	and	and	CCONJ
gs-4321	503	19	intercellular	intercellular	ADJ
gs-4321	503	20	communication	communication	NOUN
gs-4321	503	21	converge	converge	VERB
gs-4321	503	22	to	to	PART
gs-4321	503	23	establish	establish	VERB
gs-4321	503	24	and	and	CCONJ
gs-4321	503	25	maintain	maintain	VERB
gs-4321	503	26	adaptable	adaptable	ADJ
gs-4321	503	27	states	state	NOUN
gs-4321	503	28	.	.	PUNCT
gs-4321	504	1	targeting	target	VERB
gs-4321	504	2	these	these	DET
gs-4321	504	3	niche	niche	NOUN
gs-4321	504	4	-	-	PUNCT
gs-4321	504	5	dependent	dependent	ADJ
gs-4321	504	6	signaling	signal	VERB
gs-4321	504	7	circuits	circuit	NOUN
gs-4321	504	8	—	—	PUNCT
gs-4321	504	9	either	either	CCONJ
gs-4321	504	10	through	through	ADP
gs-4321	504	11	direct	direct	ADJ
gs-4321	504	12	inhibition	inhibition	NOUN
gs-4321	504	13	of	of	ADP
gs-4321	504	14	key	key	ADJ
gs-4321	504	15	ligands	ligand	NOUN
gs-4321	504	16	/	/	SYM
gs-4321	504	17	receptors	receptor	NOUN
gs-4321	504	18	or	or	CCONJ
gs-4321	504	19	by	by	ADP
gs-4321	504	20	georgian	georgian	PROPN
gs-4321	504	21	scientists/	scientists/	NUM
gs-4321	504	22	.	.	PUNCT
gs-4321	505	1	7	7	NUM
gs-4321	505	2	n	n	DET
gs-4321	505	3	4	4	NUM
gs-4321	505	4	,	,	PUNCT
gs-4321	505	5	2025	2025	NUM
gs-4321	505	6	365	365	NUM
gs-4321	505	7	disrupting	disrupt	VERB
gs-4321	505	8	stromal	stromal	ADJ
gs-4321	505	9	and	and	CCONJ
gs-4321	505	10	immune	immune	ADJ
gs-4321	505	11	support	support	NOUN
gs-4321	505	12	networks	network	NOUN
gs-4321	505	13	—	—	PUNCT
gs-4321	505	14	represents	represent	VERB
gs-4321	505	15	a	a	DET
gs-4321	505	16	promising	promising	ADJ
gs-4321	505	17	strategy	strategy	NOUN
gs-4321	505	18	for	for	ADP
gs-4321	505	19	preventing	prevent	VERB
gs-4321	505	20	therapy	therapy	NOUN
gs-4321	505	21	-	-	PUNCT
gs-4321	505	22	induced	induced	ADJ
gs-4321	505	23	reprogramming	reprogramming	NOUN
gs-4321	505	24	and	and	CCONJ
gs-4321	505	25	eliminating	eliminate	VERB
gs-4321	505	26	therapy	therapy	NOUN
gs-4321	505	27	-	-	PUNCT
gs-4321	505	28	resistant	resistant	ADJ
gs-4321	505	29	populations	population	NOUN
gs-4321	505	30	.	.	PUNCT
gs-4321	506	1	furthermore	furthermore	ADV
gs-4321	506	2	,	,	PUNCT
gs-4321	506	3	the	the	DET
gs-4321	506	4	spatial	spatial	ADJ
gs-4321	506	5	restriction	restriction	NOUN
gs-4321	506	6	of	of	ADP
gs-4321	506	7	these	these	DET
gs-4321	506	8	interactions	interaction	NOUN
gs-4321	506	9	suggests	suggest	VERB
gs-4321	506	10	that	that	SCONJ
gs-4321	506	11	localized	localize	VERB
gs-4321	506	12	therapeutic	therapeutic	ADJ
gs-4321	506	13	interventions	intervention	NOUN
gs-4321	506	14	,	,	PUNCT
gs-4321	506	15	such	such	ADJ
gs-4321	506	16	as	as	ADP
gs-4321	506	17	antibody	antibody	NOUN
gs-4321	506	18	-	-	PUNCT
gs-4321	506	19	drug	drug	NOUN
gs-4321	506	20	conjugates	conjugate	NOUN
gs-4321	506	21	or	or	CCONJ
gs-4321	506	22	car	car	NOUN
gs-4321	506	23	-	-	PUNCT
gs-4321	506	24	t	t	NOUN
gs-4321	506	25	cells	cell	NOUN
gs-4321	506	26	targeting	target	VERB
gs-4321	506	27	niche	niche	NOUN
gs-4321	506	28	-	-	PUNCT
gs-4321	506	29	specific	specific	ADJ
gs-4321	506	30	antigens	antigen	NOUN
gs-4321	506	31	,	,	PUNCT
gs-4321	506	32	may	may	AUX
gs-4321	506	33	offer	offer	VERB
gs-4321	506	34	enhanced	enhanced	ADJ
gs-4321	506	35	efficacy	efficacy	NOUN
gs-4321	506	36	compared	compare	VERB
gs-4321	506	37	to	to	ADP
gs-4321	506	38	systemic	systemic	ADJ
gs-4321	506	39	approaches	approach	NOUN
gs-4321	506	40	.	.	PUNCT
gs-4321	507	1	discussion	discussion	NOUN
gs-4321	507	2	the	the	DET
gs-4321	507	3	integrative	integrative	ADJ
gs-4321	507	4	single	single	ADJ
gs-4321	507	5	-	-	PUNCT
gs-4321	507	6	cell	cell	NOUN
gs-4321	507	7	analyses	analysis	NOUN
gs-4321	507	8	performed	perform	VERB
gs-4321	507	9	in	in	ADP
gs-4321	507	10	this	this	DET
gs-4321	507	11	study	study	NOUN
gs-4321	507	12	reveal	reveal	VERB
gs-4321	507	13	a	a	DET
gs-4321	507	14	coherent	coherent	ADJ
gs-4321	507	15	and	and	CCONJ
gs-4321	507	16	biologically	biologically	ADV
gs-4321	507	17	robust	robust	ADJ
gs-4321	507	18	model	model	NOUN
gs-4321	507	19	of	of	ADP
gs-4321	507	20	malignant	malignant	ADJ
gs-4321	507	21	cell	cell	NOUN
gs-4321	507	22	plasticity	plasticity	NOUN
gs-4321	507	23	,	,	PUNCT
gs-4321	507	24	highlighting	highlight	VERB
gs-4321	507	25	the	the	DET
gs-4321	507	26	interplay	interplay	NOUN
gs-4321	507	27	between	between	ADP
gs-4321	507	28	transcriptional	transcriptional	ADJ
gs-4321	507	29	identity	identity	NOUN
gs-4321	507	30	,	,	PUNCT
gs-4321	507	31	regulatory	regulatory	ADJ
gs-4321	507	32	circuitry	circuitry	NOUN
gs-4321	507	33	,	,	PUNCT
gs-4321	507	34	microenvironmental	microenvironmental	ADJ
gs-4321	507	35	interactions	interaction	NOUN
gs-4321	507	36	,	,	PUNCT
gs-4321	507	37	and	and	CCONJ
gs-4321	507	38	statetransition	statetransition	NOUN
gs-4321	507	39	dynamics	dynamic	NOUN
gs-4321	507	40	.	.	PUNCT
gs-4321	508	1	these	these	DET
gs-4321	508	2	findings	finding	NOUN
gs-4321	508	3	reinforce	reinforce	VERB
gs-4321	508	4	the	the	DET
gs-4321	508	5	growing	grow	VERB
gs-4321	508	6	consensus	consensus	NOUN
gs-4321	508	7	that	that	SCONJ
gs-4321	508	8	tumor	tumor	NOUN
gs-4321	508	9	evolution	evolution	NOUN
gs-4321	508	10	is	be	AUX
gs-4321	508	11	strongly	strongly	ADV
gs-4321	508	12	shaped	shape	VERB
gs-4321	508	13	by	by	ADP
gs-4321	508	14	cellular	cellular	ADJ
gs-4321	508	15	flexibility	flexibility	NOUN
gs-4321	508	16	rather	rather	ADV
gs-4321	508	17	than	than	ADP
gs-4321	508	18	by	by	ADP
gs-4321	508	19	rigid	rigid	ADJ
gs-4321	508	20	hierarchical	hierarchical	ADJ
gs-4321	508	21	structures	structure	NOUN
gs-4321	508	22	.	.	PUNCT
gs-4321	509	1	similar	similar	ADJ
gs-4321	509	2	observations	observation	NOUN
gs-4321	509	3	have	have	AUX
gs-4321	509	4	been	be	AUX
gs-4321	509	5	reported	report	VERB
gs-4321	509	6	across	across	ADP
gs-4321	509	7	multiple	multiple	ADJ
gs-4321	509	8	cancer	cancer	NOUN
gs-4321	509	9	types	type	NOUN
gs-4321	509	10	,	,	PUNCT
gs-4321	509	11	where	where	SCONJ
gs-4321	509	12	single	single	ADJ
gs-4321	509	13	-	-	PUNCT
gs-4321	509	14	cell	cell	NOUN
gs-4321	509	15	transcriptomics	transcriptomic	NOUN
gs-4321	509	16	has	have	AUX
gs-4321	509	17	demonstrated	demonstrate	VERB
gs-4321	509	18	that	that	SCONJ
gs-4321	509	19	malignant	malignant	ADJ
gs-4321	509	20	populations	population	NOUN
gs-4321	509	21	exist	exist	VERB
gs-4321	509	22	along	along	ADP
gs-4321	509	23	phenotypic	phenotypic	ADJ
gs-4321	509	24	continua	continuum	NOUN
gs-4321	509	25	rather	rather	ADV
gs-4321	509	26	than	than	ADP
gs-4321	509	27	within	within	ADP
gs-4321	509	28	discrete	discrete	ADJ
gs-4321	509	29	and	and	CCONJ
gs-4321	509	30	terminally	terminally	ADV
gs-4321	509	31	fixed	fix	VERB
gs-4321	509	32	states	state	NOUN
gs-4321	509	33	(	(	PUNCT
gs-4321	509	34	tirosh	tirosh	NOUN
gs-4321	509	35	et	et	PROPN
gs-4321	509	36	al	al	PROPN
gs-4321	509	37	.	.	PROPN
gs-4321	509	38	,	,	PUNCT
gs-4321	509	39	2016	2016	NUM
gs-4321	509	40	;	;	PUNCT
gs-4321	509	41	neftel	neftel	NOUN
gs-4321	509	42	et	et	PROPN
gs-4321	509	43	al	al	PROPN
gs-4321	509	44	.	.	PROPN
gs-4321	509	45	,	,	PUNCT
gs-4321	509	46	2019	2019	NUM
gs-4321	509	47	)	)	PUNCT
gs-4321	509	48	.	.	PUNCT
gs-4321	510	1	the	the	DET
gs-4321	510	2	presence	presence	NOUN
gs-4321	510	3	of	of	ADP
gs-4321	510	4	intermediate	intermediate	ADJ
gs-4321	510	5	populations	population	NOUN
gs-4321	510	6	identified	identify	VERB
gs-4321	510	7	in	in	ADP
gs-4321	510	8	our	our	PRON
gs-4321	510	9	data	datum	NOUN
gs-4321	510	10	supports	support	VERB
gs-4321	510	11	the	the	DET
gs-4321	510	12	concept	concept	NOUN
gs-4321	510	13	of	of	ADP
gs-4321	510	14	metastable	metastable	ADJ
gs-4321	510	15	states	state	NOUN
gs-4321	510	16	that	that	PRON
gs-4321	510	17	facilitate	facilitate	VERB
gs-4321	510	18	dynamic	dynamic	ADJ
gs-4321	510	19	responses	response	NOUN
gs-4321	510	20	to	to	ADP
gs-4321	510	21	environmental	environmental	ADJ
gs-4321	510	22	pressures	pressure	NOUN
gs-4321	510	23	and	and	CCONJ
gs-4321	510	24	therapeutic	therapeutic	ADJ
gs-4321	510	25	stress	stress	NOUN
gs-4321	510	26	.	.	PUNCT
gs-4321	511	1	a	a	DET
gs-4321	511	2	central	central	ADJ
gs-4321	511	3	implication	implication	NOUN
gs-4321	511	4	of	of	ADP
gs-4321	511	5	our	our	PRON
gs-4321	511	6	results	result	NOUN
gs-4321	511	7	is	be	AUX
gs-4321	511	8	that	that	SCONJ
gs-4321	511	9	the	the	DET
gs-4321	511	10	intermediate	intermediate	ADJ
gs-4321	511	11	state	state	NOUN
gs-4321	511	12	represents	represent	VERB
gs-4321	511	13	a	a	DET
gs-4321	511	14	critical	critical	ADJ
gs-4321	511	15	hub	hub	NOUN
gs-4321	511	16	for	for	ADP
gs-4321	511	17	adaptive	adaptive	ADJ
gs-4321	511	18	behavior	behavior	NOUN
gs-4321	511	19	.	.	PUNCT
gs-4321	512	1	the	the	DET
gs-4321	512	2	convergence	convergence	NOUN
gs-4321	512	3	of	of	ADP
gs-4321	512	4	transcriptional	transcriptional	ADJ
gs-4321	512	5	activity	activity	NOUN
gs-4321	512	6	,	,	PUNCT
gs-4321	512	7	stamens	stamen	NOUN
gs-4321	512	8	enrichment	enrichment	NOUN
gs-4321	512	9	,	,	PUNCT
gs-4321	512	10	pseudo	pseudo	NOUN
gs-4321	512	11	time	time	NOUN
gs-4321	512	12	progression	progression	NOUN
gs-4321	512	13	,	,	PUNCT
gs-4321	512	14	and	and	CCONJ
gs-4321	512	15	regulatory	regulatory	ADJ
gs-4321	512	16	activation	activation	NOUN
gs-4321	512	17	within	within	ADP
gs-4321	512	18	this	this	DET
gs-4321	512	19	compartment	compartment	NOUN
gs-4321	512	20	strongly	strongly	ADV
gs-4321	512	21	suggests	suggest	VERB
gs-4321	512	22	that	that	SCONJ
gs-4321	512	23	it	it	PRON
gs-4321	512	24	serves	serve	VERB
gs-4321	512	25	as	as	ADP
gs-4321	512	26	a	a	DET
gs-4321	512	27	transition	transition	NOUN
gs-4321	512	28	zone	zone	NOUN
gs-4321	512	29	enabling	enable	VERB
gs-4321	512	30	malignant	malignant	ADJ
gs-4321	512	31	cells	cell	NOUN
gs-4321	512	32	to	to	PART
gs-4321	512	33	shift	shift	VERB
gs-4321	512	34	toward	toward	ADP
gs-4321	512	35	more	more	ADV
gs-4321	512	36	resilient	resilient	ADJ
gs-4321	512	37	phenotypes	phenotype	NOUN
gs-4321	512	38	.	.	PUNCT
gs-4321	513	1	similar	similar	ADJ
gs-4321	513	2	intermediate	intermediate	ADJ
gs-4321	513	3	states	state	NOUN
gs-4321	513	4	have	have	AUX
gs-4321	513	5	been	be	AUX
gs-4321	513	6	documented	document	VERB
gs-4321	513	7	in	in	ADP
gs-4321	513	8	epithelial	epithelial	ADJ
gs-4321	513	9	tumors	tumor	NOUN
gs-4321	513	10	,	,	PUNCT
gs-4321	513	11	where	where	SCONJ
gs-4321	513	12	partial	partial	ADJ
gs-4321	513	13	emt	emt	PROPN
gs-4321	513	14	phenotypes	phenotype	NOUN
gs-4321	513	15	contribute	contribute	VERB
gs-4321	513	16	to	to	ADP
gs-4321	513	17	metastatic	metastatic	ADJ
gs-4321	513	18	initiation	initiation	NOUN
gs-4321	513	19	and	and	CCONJ
gs-4321	513	20	treatment	treatment	NOUN
gs-4321	513	21	resistance	resistance	NOUN
gs-4321	513	22	(	(	PUNCT
gs-4321	513	23	pastushenko	pastushenko	NOUN
gs-4321	513	24	et	et	PROPN
gs-4321	513	25	al	al	PROPN
gs-4321	513	26	.	.	PROPN
gs-4321	513	27	,	,	PUNCT
gs-4321	513	28	2018	2018	NUM
gs-4321	513	29	)	)	PUNCT
gs-4321	513	30	.	.	PUNCT
gs-4321	514	1	the	the	DET
gs-4321	514	2	consistent	consistent	ADJ
gs-4321	514	3	identification	identification	NOUN
gs-4321	514	4	of	of	ADP
gs-4321	514	5	analogous	analogous	ADJ
gs-4321	514	6	populations	population	NOUN
gs-4321	514	7	across	across	ADP
gs-4321	514	8	datasets	dataset	NOUN
gs-4321	514	9	in	in	ADP
gs-4321	514	10	this	this	DET
gs-4321	514	11	study	study	NOUN
gs-4321	514	12	further	far	ADV
gs-4321	514	13	supports	support	VERB
gs-4321	514	14	the	the	DET
gs-4321	514	15	hypothesis	hypothesis	NOUN
gs-4321	514	16	that	that	PRON
gs-4321	514	17	such	such	ADJ
gs-4321	514	18	transitional	transitional	ADJ
gs-4321	514	19	phenotypes	phenotype	NOUN
gs-4321	514	20	are	be	AUX
gs-4321	514	21	fundamental	fundamental	ADJ
gs-4321	514	22	to	to	ADP
gs-4321	514	23	tumor	tumor	NOUN
gs-4321	514	24	adaptability	adaptability	NOUN
gs-4321	514	25	.	.	PUNCT
gs-4321	515	1	our	our	PRON
gs-4321	515	2	regulatory	regulatory	ADJ
gs-4321	515	3	network	network	NOUN
gs-4321	515	4	analysis	analysis	NOUN
gs-4321	515	5	provides	provide	VERB
gs-4321	515	6	additional	additional	ADJ
gs-4321	515	7	mechanistic	mechanistic	ADJ
gs-4321	515	8	insight	insight	NOUN
gs-4321	515	9	into	into	ADP
gs-4321	515	10	how	how	SCONJ
gs-4321	515	11	malignant	malignant	ADJ
gs-4321	515	12	cells	cell	NOUN
gs-4321	515	13	acquire	acquire	VERB
gs-4321	515	14	plasticity	plasticity	NOUN
gs-4321	515	15	.	.	PUNCT
gs-4321	516	1	the	the	DET
gs-4321	516	2	graded	grade	VERB
gs-4321	516	3	activation	activation	NOUN
gs-4321	516	4	of	of	ADP
gs-4321	516	5	sox2	sox2	NOUN
gs-4321	516	6	,	,	PUNCT
gs-4321	516	7	jun	jun	PROPN
gs-4321	516	8	,	,	PUNCT
gs-4321	516	9	mitf	mitf	NOUN
gs-4321	516	10	,	,	PUNCT
gs-4321	516	11	and	and	CCONJ
gs-4321	516	12	zeb1	zeb1	PROPN
gs-4321	516	13	across	across	ADP
gs-4321	516	14	the	the	DET
gs-4321	516	15	state	state	NOUN
gs-4321	516	16	continuum	continuum	NOUN
gs-4321	516	17	is	be	AUX
gs-4321	516	18	highly	highly	ADV
gs-4321	516	19	consistent	consistent	ADJ
gs-4321	516	20	with	with	ADP
gs-4321	516	21	regulatory	regulatory	ADJ
gs-4321	516	22	models	model	NOUN
gs-4321	516	23	previously	previously	ADV
gs-4321	516	24	described	describe	VERB
gs-4321	516	25	in	in	ADP
gs-4321	516	26	melanoma	melanoma	NOUN
gs-4321	516	27	,	,	PUNCT
gs-4321	516	28	glioblastoma	glioblastoma	NOUN
gs-4321	516	29	,	,	PUNCT
gs-4321	516	30	and	and	CCONJ
gs-4321	516	31	breast	breast	NOUN
gs-4321	516	32	cancer	cancer	NOUN
gs-4321	516	33	(	(	PUNCT
gs-4321	516	34	rambow	rambow	NOUN
gs-4321	516	35	et	et	PROPN
gs-4321	516	36	al	al	PROPN
gs-4321	516	37	.	.	PROPN
gs-4321	516	38	,	,	PUNCT
gs-4321	516	39	2018	2018	NUM
gs-4321	516	40	;	;	PUNCT
gs-4321	516	41	suvà	suvà	NOUN
gs-4321	516	42	et	et	PROPN
gs-4321	516	43	al	al	PROPN
gs-4321	516	44	.	.	PROPN
gs-4321	516	45	,	,	PUNCT
gs-4321	516	46	2014	2014	NUM
gs-4321	516	47	)	)	PUNCT
gs-4321	516	48	.	.	PUNCT
gs-4321	517	1	these	these	DET
gs-4321	517	2	regulators	regulator	NOUN
gs-4321	517	3	are	be	AUX
gs-4321	517	4	known	know	VERB
gs-4321	517	5	to	to	PART
gs-4321	517	6	mediate	mediate	VERB
gs-4321	517	7	lineage	lineage	NOUN
gs-4321	517	8	remodeling	remodeling	NOUN
gs-4321	517	9	,	,	PUNCT
gs-4321	517	10	stress	stress	NOUN
gs-4321	517	11	adaptation	adaptation	NOUN
gs-4321	517	12	,	,	PUNCT
gs-4321	517	13	and	and	CCONJ
gs-4321	517	14	transcriptional	transcriptional	ADJ
gs-4321	517	15	reprogramming	reprogramming	NOUN
gs-4321	517	16	,	,	PUNCT
gs-4321	517	17	and	and	CCONJ
gs-4321	517	18	their	their	PRON
gs-4321	517	19	progressive	progressive	ADJ
gs-4321	517	20	activation	activation	NOUN
gs-4321	517	21	suggests	suggest	VERB
gs-4321	517	22	increasing	increase	VERB
gs-4321	517	23	regulatory	regulatory	ADJ
gs-4321	517	24	entropy	entropy	NOUN
gs-4321	517	25	as	as	SCONJ
gs-4321	517	26	cells	cell	NOUN
gs-4321	517	27	transition	transition	NOUN
gs-4321	517	28	toward	toward	ADP
gs-4321	517	29	more	more	ADJ
gs-4321	517	30	stem	stem	NOUN
gs-4321	517	31	-	-	PUNCT
gs-4321	517	32	like	like	ADJ
gs-4321	517	33	identities	identity	NOUN
gs-4321	517	34	.	.	PUNCT
gs-4321	518	1	this	this	DET
gs-4321	518	2	observation	observation	NOUN
gs-4321	518	3	aligns	align	VERB
gs-4321	518	4	with	with	ADP
gs-4321	518	5	prior	prior	ADJ
gs-4321	518	6	findings	finding	NOUN
gs-4321	518	7	that	that	SCONJ
gs-4321	518	8	highly	highly	ADV
gs-4321	518	9	plastic	plastic	ADJ
gs-4321	518	10	cancer	cancer	NOUN
gs-4321	518	11	cells	cell	NOUN
gs-4321	518	12	show	show	VERB
gs-4321	518	13	elevated	elevated	ADJ
gs-4321	518	14	transcriptional	transcriptional	NOUN
gs-4321	518	15	noise	noise	NOUN
gs-4321	518	16	and	and	CCONJ
gs-4321	518	17	multi	multi	ADJ
gs-4321	518	18	-	-	ADJ
gs-4321	518	19	lineage	lineage	ADJ
gs-4321	518	20	transcription	transcription	NOUN
gs-4321	518	21	factor	factor	NOUN
gs-4321	518	22	activity	activity	NOUN
gs-4321	518	23	,	,	PUNCT
gs-4321	518	24	enabling	enable	VERB
gs-4321	518	25	rapid	rapid	ADJ
gs-4321	518	26	shifts	shift	NOUN
gs-4321	518	27	in	in	ADP
gs-4321	518	28	functional	functional	ADJ
gs-4321	518	29	behavior	behavior	NOUN
gs-4321	518	30	(	(	PUNCT
gs-4321	518	31	teschendorff	teschendorff	NOUN
gs-4321	518	32	and	and	CCONJ
gs-4321	518	33	enver	enver	PROPN
gs-4321	518	34	,	,	PUNCT
gs-4321	518	35	2017	2017	NUM
gs-4321	518	36	)	)	PUNCT
gs-4321	518	37	.	.	PUNCT
gs-4321	519	1	the	the	DET
gs-4321	519	2	transition	transition	NOUN
gs-4321	519	3	dynamics	dynamic	NOUN
gs-4321	519	4	inferred	infer	VERB
gs-4321	519	5	from	from	ADP
gs-4321	519	6	streamline	streamline	VERB
gs-4321	519	7	analysis	analysis	NOUN
gs-4321	519	8	underscore	underscore	VERB
gs-4321	519	9	the	the	DET
gs-4321	519	10	directional	directional	ADJ
gs-4321	519	11	nature	nature	NOUN
gs-4321	519	12	of	of	ADP
gs-4321	519	13	adaptability	adaptability	NOUN
gs-4321	519	14	.	.	PUNCT
gs-4321	520	1	instead	instead	ADV
gs-4321	520	2	of	of	ADP
gs-4321	520	3	random	random	ADJ
gs-4321	520	4	fluctuations	fluctuation	NOUN
gs-4321	520	5	between	between	ADP
gs-4321	520	6	states	state	NOUN
gs-4321	520	7	,	,	PUNCT
gs-4321	520	8	malignant	malignant	ADJ
gs-4321	520	9	cells	cell	NOUN
gs-4321	520	10	appear	appear	VERB
gs-4321	520	11	georgian	georgian	ADJ
gs-4321	520	12	scientists/	scientists/	NUM
gs-4321	520	13	.	.	PUNCT
gs-4321	521	1	7	7	NUM
gs-4321	521	2	n	n	PRON
gs-4321	521	3	4	4	NUM
gs-4321	521	4	,	,	PUNCT
gs-4321	521	5	2025	2025	NUM
gs-4321	521	6	366	366	NUM
gs-4321	521	7	to	to	PART
gs-4321	521	8	move	move	VERB
gs-4321	521	9	along	along	ADP
gs-4321	521	10	structured	structured	ADJ
gs-4321	521	11	trajectories	trajectory	NOUN
gs-4321	521	12	toward	toward	ADP
gs-4321	521	13	phenotypes	phenotype	NOUN
gs-4321	521	14	optimized	optimize	VERB
gs-4321	521	15	for	for	ADP
gs-4321	521	16	survival	survival	NOUN
gs-4321	521	17	under	under	ADP
gs-4321	521	18	stress	stress	NOUN
gs-4321	521	19	.	.	PUNCT
gs-4321	522	1	similar	similar	ADJ
gs-4321	522	2	directional	directional	ADJ
gs-4321	522	3	flows	flow	NOUN
gs-4321	522	4	have	have	AUX
gs-4321	522	5	been	be	AUX
gs-4321	522	6	identified	identify	VERB
gs-4321	522	7	in	in	ADP
gs-4321	522	8	rna	rna	NOUN
gs-4321	522	9	velocity	velocity	NOUN
gs-4321	522	10	studies	study	NOUN
gs-4321	522	11	of	of	ADP
gs-4321	522	12	melanoma	melanoma	NOUN
gs-4321	522	13	and	and	CCONJ
gs-4321	522	14	glioma	glioma	NOUN
gs-4321	522	15	,	,	PUNCT
gs-4321	522	16	where	where	SCONJ
gs-4321	522	17	cells	cell	NOUN
gs-4321	522	18	adopt	adopt	VERB
gs-4321	522	19	injury	injury	NOUN
gs-4321	522	20	-	-	PUNCT
gs-4321	522	21	associated	associate	VERB
gs-4321	522	22	,	,	PUNCT
gs-4321	522	23	neural	neural	ADJ
gs-4321	522	24	-	-	PUNCT
gs-4321	522	25	crest	crest	NOUN
gs-4321	522	26	–	–	PUNCT
gs-4321	522	27	like	like	ADJ
gs-4321	522	28	,	,	PUNCT
gs-4321	522	29	or	or	CCONJ
gs-4321	522	30	mesenchymal	mesenchymal	ADJ
gs-4321	522	31	states	state	NOUN
gs-4321	522	32	in	in	ADP
gs-4321	522	33	response	response	NOUN
gs-4321	522	34	to	to	ADP
gs-4321	522	35	therapeutic	therapeutic	ADJ
gs-4321	522	36	pressures	pressure	NOUN
gs-4321	522	37	(	(	PUNCT
gs-4321	522	38	la	la	X
gs-4321	522	39	manno	manno	PROPN
gs-4321	522	40	et	et	PROPN
gs-4321	522	41	al	al	PROPN
gs-4321	522	42	.	.	PROPN
gs-4321	522	43	,	,	PUNCT
gs-4321	522	44	2018	2018	NUM
gs-4321	522	45	;	;	PUNCT
gs-4321	522	46	qiu	qiu	PROPN
gs-4321	522	47	et	et	PROPN
gs-4321	522	48	al	al	PROPN
gs-4321	522	49	.	.	PROPN
gs-4321	522	50	,	,	PUNCT
gs-4321	522	51	2022	2022	NUM
gs-4321	522	52	)	)	PUNCT
gs-4321	522	53	.	.	PUNCT
gs-4321	523	1	these	these	DET
gs-4321	523	2	parallels	parallel	NOUN
gs-4321	523	3	reinforce	reinforce	VERB
gs-4321	523	4	the	the	DET
gs-4321	523	5	biological	biological	ADJ
gs-4321	523	6	plausibility	plausibility	NOUN
gs-4321	523	7	of	of	ADP
gs-4321	523	8	our	our	PRON
gs-4321	523	9	findings	finding	NOUN
gs-4321	523	10	and	and	CCONJ
gs-4321	523	11	further	far	ADV
gs-4321	523	12	validate	validate	VERB
gs-4321	523	13	the	the	DET
gs-4321	523	14	presence	presence	NOUN
gs-4321	523	15	of	of	ADP
gs-4321	523	16	conserved	conserve	VERB
gs-4321	523	17	adaptive	adaptive	ADJ
gs-4321	523	18	routes	route	NOUN
gs-4321	523	19	in	in	ADP
gs-4321	523	20	cancer	cancer	NOUN
gs-4321	523	21	.	.	PUNCT
gs-4321	524	1	intermediate	intermediate	ADJ
gs-4321	524	2	states	state	NOUN
gs-4321	524	3	as	as	ADP
gs-4321	524	4	drivers	driver	NOUN
gs-4321	524	5	of	of	ADP
gs-4321	524	6	adaptive	adaptive	ADJ
gs-4321	524	7	potential	potential	NOUN
gs-4321	524	8	the	the	DET
gs-4321	524	9	identification	identification	NOUN
gs-4321	524	10	of	of	ADP
gs-4321	524	11	a	a	DET
gs-4321	524	12	transcriptionally	transcriptionally	ADV
gs-4321	524	13	and	and	CCONJ
gs-4321	524	14	functionally	functionally	ADV
gs-4321	524	15	distinct	distinct	ADJ
gs-4321	524	16	intermediate	intermediate	ADJ
gs-4321	524	17	state	state	NOUN
gs-4321	524	18	across	across	ADP
gs-4321	524	19	multiple	multiple	ADJ
gs-4321	524	20	tumor	tumor	NOUN
gs-4321	524	21	types	type	NOUN
gs-4321	524	22	underscores	underscore	VERB
gs-4321	524	23	its	its	PRON
gs-4321	524	24	central	central	ADJ
gs-4321	524	25	role	role	NOUN
gs-4321	524	26	in	in	ADP
gs-4321	524	27	shaping	shape	VERB
gs-4321	524	28	adaptive	adaptive	ADJ
gs-4321	524	29	potential	potential	NOUN
gs-4321	524	30	.	.	PUNCT
gs-4321	525	1	this	this	DET
gs-4321	525	2	population	population	NOUN
gs-4321	525	3	consistently	consistently	ADV
gs-4321	525	4	demonstrated	demonstrate	VERB
gs-4321	525	5	elevated	elevated	ADJ
gs-4321	525	6	stemness	stemness	NOUN
gs-4321	525	7	scores	score	NOUN
gs-4321	525	8	,	,	PUNCT
gs-4321	525	9	partial	partial	ADJ
gs-4321	525	10	activation	activation	NOUN
gs-4321	525	11	of	of	ADP
gs-4321	525	12	lineage	lineage	NOUN
gs-4321	525	13	-	-	PUNCT
gs-4321	525	14	remodeling	remodeling	NOUN
gs-4321	525	15	transcription	transcription	NOUN
gs-4321	525	16	factors	factor	NOUN
gs-4321	525	17	,	,	PUNCT
gs-4321	525	18	and	and	CCONJ
gs-4321	525	19	enhanced	enhance	VERB
gs-4321	525	20	signaling	signal	VERB
gs-4321	525	21	responsiveness	responsiveness	NOUN
gs-4321	525	22	.	.	PUNCT
gs-4321	526	1	such	such	ADJ
gs-4321	526	2	characteristics	characteristic	NOUN
gs-4321	526	3	strongly	strongly	ADV
gs-4321	526	4	resemble	resemble	VERB
gs-4321	526	5	the	the	DET
gs-4321	526	6	“	"	PUNCT
gs-4321	526	7	cell	cell	NOUN
gs-4321	526	8	-	-	PUNCT
gs-4321	526	9	state	state	NOUN
gs-4321	526	10	plasticity	plasticity	NOUN
gs-4321	526	11	hubs	hub	NOUN
gs-4321	526	12	”	"	PUNCT
gs-4321	526	13	documented	document	VERB
gs-4321	526	14	in	in	ADP
gs-4321	526	15	melanoma	melanoma	NOUN
gs-4321	526	16	,	,	PUNCT
gs-4321	526	17	breast	breast	NOUN
gs-4321	526	18	cancer	cancer	NOUN
gs-4321	526	19	,	,	PUNCT
gs-4321	526	20	and	and	CCONJ
gs-4321	526	21	lung	lung	NOUN
gs-4321	526	22	adenocarcinoma	adenocarcinoma	NOUN
gs-4321	526	23	,	,	PUNCT
gs-4321	526	24	where	where	SCONJ
gs-4321	526	25	hybrid	hybrid	ADJ
gs-4321	526	26	phenotypes	phenotype	NOUN
gs-4321	526	27	facilitate	facilitate	VERB
gs-4321	526	28	rapid	rapid	ADJ
gs-4321	526	29	transitions	transition	NOUN
gs-4321	526	30	under	under	ADP
gs-4321	526	31	therapeutic	therapeutic	ADJ
gs-4321	526	32	or	or	CCONJ
gs-4321	526	33	environmental	environmental	ADJ
gs-4321	526	34	pressure	pressure	NOUN
gs-4321	526	35	(	(	PUNCT
gs-4321	526	36	rambow	rambow	NOUN
gs-4321	526	37	et	et	PROPN
gs-4321	526	38	al	al	PROPN
gs-4321	526	39	.	.	PROPN
gs-4321	526	40	,	,	PUNCT
gs-4321	526	41	2018	2018	NUM
gs-4321	526	42	;	;	PUNCT
gs-4321	526	43	marjanovic	marjanovic	PROPN
gs-4321	526	44	et	et	PROPN
gs-4321	526	45	al	al	PROPN
gs-4321	526	46	.	.	PROPN
gs-4321	526	47	,	,	PUNCT
gs-4321	526	48	2020	2020	NUM
gs-4321	526	49	)	)	PUNCT
gs-4321	526	50	.	.	PUNCT
gs-4321	527	1	these	these	DET
gs-4321	527	2	intermediate	intermediate	ADJ
gs-4321	527	3	cells	cell	NOUN
gs-4321	527	4	often	often	ADV
gs-4321	527	5	exhibit	exhibit	VERB
gs-4321	527	6	broadened	broaden	VERB
gs-4321	527	7	chromatin	chromatin	NOUN
gs-4321	527	8	accessibility	accessibility	NOUN
gs-4321	527	9	and	and	CCONJ
gs-4321	527	10	elevated	elevated	ADJ
gs-4321	527	11	transcriptional	transcriptional	NOUN
gs-4321	527	12	entropy	entropy	NOUN
gs-4321	527	13	,	,	PUNCT
gs-4321	527	14	properties	property	NOUN
gs-4321	527	15	that	that	PRON
gs-4321	527	16	increase	increase	VERB
gs-4321	527	17	lineage	lineage	NOUN
gs-4321	527	18	flexibility	flexibility	NOUN
gs-4321	527	19	and	and	CCONJ
gs-4321	527	20	support	support	NOUN
gs-4321	527	21	survival	survival	NOUN
gs-4321	527	22	in	in	ADP
gs-4321	527	23	fluctuating	fluctuate	VERB
gs-4321	527	24	microenvironments	microenvironment	NOUN
gs-4321	527	25	(	(	PUNCT
gs-4321	527	26	corces	corce	NOUN
gs-4321	527	27	et	et	NOUN
gs-4321	527	28	al	al	PROPN
gs-4321	527	29	.	.	PROPN
gs-4321	527	30	,	,	PUNCT
gs-4321	527	31	2018	2018	NUM
gs-4321	527	32	)	)	PUNCT
gs-4321	527	33	.	.	PUNCT
gs-4321	528	1	our	our	PRON
gs-4321	528	2	results	result	NOUN
gs-4321	528	3	align	align	VERB
gs-4321	528	4	closely	closely	ADV
gs-4321	528	5	with	with	ADP
gs-4321	528	6	these	these	DET
gs-4321	528	7	findings	finding	NOUN
gs-4321	528	8	and	and	CCONJ
gs-4321	528	9	further	far	ADV
gs-4321	528	10	reinforce	reinforce	VERB
gs-4321	528	11	the	the	DET
gs-4321	528	12	concept	concept	NOUN
gs-4321	528	13	that	that	SCONJ
gs-4321	528	14	adaptive	adaptive	ADJ
gs-4321	528	15	behavior	behavior	NOUN
gs-4321	528	16	emerges	emerge	VERB
gs-4321	528	17	through	through	ADP
gs-4321	528	18	intermediate	intermediate	ADJ
gs-4321	528	19	configurations	configuration	NOUN
gs-4321	528	20	rather	rather	ADV
gs-4321	528	21	than	than	ADP
gs-4321	528	22	direct	direct	ADJ
gs-4321	528	23	transitions	transition	NOUN
gs-4321	528	24	from	from	ADP
gs-4321	528	25	fully	fully	ADV
gs-4321	528	26	differentiated	differentiated	ADJ
gs-4321	528	27	to	to	PART
gs-4321	528	28	fully	fully	ADV
gs-4321	528	29	stem	stem	VERB
gs-4321	528	30	-	-	PUNCT
gs-4321	528	31	like	like	ADJ
gs-4321	528	32	states	state	NOUN
gs-4321	528	33	.	.	PUNCT
gs-4321	529	1	regulatory	regulatory	ADJ
gs-4321	529	2	networks	network	NOUN
gs-4321	529	3	underlying	underlie	VERB
gs-4321	529	4	plasticity	plasticity	NOUN
gs-4321	529	5	regulatory	regulatory	ADJ
gs-4321	529	6	network	network	NOUN
gs-4321	529	7	analysis	analysis	NOUN
gs-4321	529	8	revealed	reveal	VERB
gs-4321	529	9	that	that	SCONJ
gs-4321	529	10	transcription	transcription	NOUN
gs-4321	529	11	factors	factor	NOUN
gs-4321	529	12	associated	associate	VERB
gs-4321	529	13	with	with	ADP
gs-4321	529	14	stress	stress	NOUN
gs-4321	529	15	responses	response	NOUN
gs-4321	529	16	and	and	CCONJ
gs-4321	529	17	lineage	lineage	NOUN
gs-4321	529	18	identity	identity	NOUN
gs-4321	529	19	—	—	PUNCT
gs-4321	529	20	such	such	ADJ
gs-4321	529	21	as	as	ADP
gs-4321	529	22	sox2	sox2	NOUN
gs-4321	529	23	,	,	PUNCT
gs-4321	529	24	jun	jun	PROPN
gs-4321	529	25	,	,	PUNCT
gs-4321	529	26	mitf	mitf	NOUN
gs-4321	529	27	,	,	PUNCT
gs-4321	529	28	and	and	CCONJ
gs-4321	529	29	zeb1	zeb1	PROPN
gs-4321	529	30	—	—	PUNCT
gs-4321	529	31	exhibited	exhibit	VERB
gs-4321	529	32	progressive	progressive	ADJ
gs-4321	529	33	activation	activation	NOUN
gs-4321	529	34	across	across	ADP
gs-4321	529	35	the	the	DET
gs-4321	529	36	phenotypic	phenotypic	NOUN
gs-4321	529	37	continuum	continuum	NOUN
gs-4321	529	38	.	.	PUNCT
gs-4321	530	1	this	this	PRON
gs-4321	530	2	graded	grade	VERB
gs-4321	530	3	structure	structure	NOUN
gs-4321	530	4	of	of	ADP
gs-4321	530	5	regulatory	regulatory	ADJ
gs-4321	530	6	influence	influence	NOUN
gs-4321	530	7	mirrors	mirror	NOUN
gs-4321	530	8	patterns	pattern	NOUN
gs-4321	530	9	observed	observe	VERB
gs-4321	530	10	in	in	ADP
gs-4321	530	11	glioblastoma	glioblastoma	NOUN
gs-4321	530	12	and	and	CCONJ
gs-4321	530	13	triple	triple	ADJ
gs-4321	530	14	-	-	PUNCT
gs-4321	530	15	negative	negative	ADJ
gs-4321	530	16	breast	breast	NOUN
gs-4321	530	17	cancer	cancer	NOUN
gs-4321	530	18	,	,	PUNCT
gs-4321	530	19	where	where	SCONJ
gs-4321	530	20	regulatory	regulatory	ADJ
gs-4321	530	21	modules	module	NOUN
gs-4321	530	22	expand	expand	VERB
gs-4321	530	23	or	or	CCONJ
gs-4321	530	24	contract	contract	VERB
gs-4321	530	25	in	in	ADP
gs-4321	530	26	response	response	NOUN
gs-4321	530	27	to	to	ADP
gs-4321	530	28	microenvironmental	microenvironmental	ADJ
gs-4321	530	29	signals	signal	NOUN
gs-4321	530	30	and	and	CCONJ
gs-4321	530	31	therapeutic	therapeutic	ADJ
gs-4321	530	32	exposure	exposure	NOUN
gs-4321	530	33	(	(	PUNCT
gs-4321	530	34	suvà	suvà	NOUN
gs-4321	530	35	et	et	PROPN
gs-4321	530	36	al	al	PROPN
gs-4321	530	37	.	.	PROPN
gs-4321	530	38	,	,	PUNCT
gs-4321	530	39	2014	2014	NUM
gs-4321	530	40	;	;	PUNCT
gs-4321	530	41	kim	kim	PROPN
gs-4321	530	42	et	et	PROPN
gs-4321	530	43	al	al	PROPN
gs-4321	530	44	.	.	PROPN
gs-4321	530	45	,	,	PUNCT
gs-4321	530	46	2020	2020	NUM
gs-4321	530	47	)	)	PUNCT
gs-4321	530	48	.	.	PUNCT
gs-4321	531	1	the	the	DET
gs-4321	531	2	presence	presence	NOUN
gs-4321	531	3	of	of	ADP
gs-4321	531	4	overlapping	overlap	VERB
gs-4321	531	5	regulons	regulon	NOUN
gs-4321	531	6	within	within	ADP
gs-4321	531	7	the	the	DET
gs-4321	531	8	intermediate	intermediate	ADJ
gs-4321	531	9	state	state	NOUN
gs-4321	531	10	suggests	suggest	VERB
gs-4321	531	11	that	that	SCONJ
gs-4321	531	12	this	this	DET
gs-4321	531	13	population	population	NOUN
gs-4321	531	14	serves	serve	VERB
gs-4321	531	15	as	as	ADP
gs-4321	531	16	a	a	DET
gs-4321	531	17	regulatory	regulatory	ADJ
gs-4321	531	18	integration	integration	NOUN
gs-4321	531	19	point	point	NOUN
gs-4321	531	20	,	,	PUNCT
gs-4321	531	21	capable	capable	ADJ
gs-4321	531	22	of	of	ADP
gs-4321	531	23	absorbing	absorb	VERB
gs-4321	531	24	and	and	CCONJ
gs-4321	531	25	translating	translate	VERB
gs-4321	531	26	diverse	diverse	ADJ
gs-4321	531	27	environmental	environmental	ADJ
gs-4321	531	28	cues	cue	NOUN
gs-4321	531	29	into	into	ADP
gs-4321	531	30	adaptive	adaptive	ADJ
gs-4321	531	31	transcriptional	transcriptional	ADJ
gs-4321	531	32	responses	response	NOUN
gs-4321	531	33	.	.	PUNCT
gs-4321	532	1	such	such	ADJ
gs-4321	532	2	regulatory	regulatory	ADJ
gs-4321	532	3	plasticity	plasticity	NOUN
gs-4321	532	4	has	have	AUX
gs-4321	532	5	been	be	AUX
gs-4321	532	6	shown	show	VERB
gs-4321	532	7	to	to	PART
gs-4321	532	8	predict	predict	VERB
gs-4321	532	9	therapy	therapy	NOUN
gs-4321	532	10	resistance	resistance	NOUN
gs-4321	532	11	,	,	PUNCT
gs-4321	532	12	metastatic	metastatic	ADJ
gs-4321	532	13	dissemination	dissemination	NOUN
gs-4321	532	14	,	,	PUNCT
gs-4321	532	15	and	and	CCONJ
gs-4321	532	16	recurrence	recurrence	NOUN
gs-4321	532	17	in	in	ADP
gs-4321	532	18	multiple	multiple	ADJ
gs-4321	532	19	tumor	tumor	NOUN
gs-4321	532	20	systems	system	NOUN
gs-4321	532	21	(	(	PUNCT
gs-4321	532	22	meacham	meacham	PROPN
gs-4321	532	23	and	and	CCONJ
gs-4321	532	24	morrison	morrison	PROPN
gs-4321	532	25	,	,	PUNCT
gs-4321	532	26	2013	2013	NUM
gs-4321	532	27	;	;	PUNCT
gs-4321	532	28	batlle	batlle	NOUN
gs-4321	532	29	and	and	CCONJ
gs-4321	532	30	clevers	clever	NOUN
gs-4321	532	31	,	,	PUNCT
gs-4321	532	32	2017	2017	NUM
gs-4321	532	33	)	)	PUNCT
gs-4321	532	34	.	.	PUNCT
gs-4321	533	1	microenvironmental	microenvironmental	ADJ
gs-4321	533	2	signals	signal	NOUN
gs-4321	533	3	guiding	guide	VERB
gs-4321	533	4	state	state	NOUN
gs-4321	533	5	transitions	transition	NOUN
gs-4321	533	6	the	the	DET
gs-4321	533	7	enhanced	enhanced	ADJ
gs-4321	533	8	signaling	signal	VERB
gs-4321	533	9	strength	strength	NOUN
gs-4321	533	10	of	of	ADP
gs-4321	533	11	il-6	il-6	NOUN
gs-4321	533	12	/	/	SYM
gs-4321	533	13	il6r	il6r	PROPN
gs-4321	533	14	,	,	PUNCT
gs-4321	533	15	tgf	tgf	PROPN
gs-4321	533	16	/	/	SYM
gs-4321	533	17	tgfbr2	tgfbr2	NOUN
gs-4321	533	18	,	,	PUNCT
gs-4321	533	19	and	and	CCONJ
gs-4321	533	20	cxcl12	cxcl12	ADJ
gs-4321	533	21	/	/	SYM
gs-4321	533	22	cxcr4	cxcr4	NOUN
gs-4321	533	23	pathways	pathway	NOUN
gs-4321	533	24	observed	observe	VERB
gs-4321	533	25	in	in	ADP
gs-4321	533	26	our	our	PRON
gs-4321	533	27	analysis	analysis	NOUN
gs-4321	533	28	indicates	indicate	VERB
gs-4321	533	29	that	that	SCONJ
gs-4321	533	30	microenvironmental	microenvironmental	ADJ
gs-4321	533	31	cues	cue	NOUN
gs-4321	533	32	play	play	VERB
gs-4321	533	33	a	a	DET
gs-4321	533	34	pivotal	pivotal	ADJ
gs-4321	533	35	role	role	NOUN
gs-4321	533	36	in	in	ADP
gs-4321	533	37	directing	direct	VERB
gs-4321	533	38	cells	cell	NOUN
gs-4321	533	39	toward	toward	ADP
gs-4321	533	40	more	more	ADJ
gs-4321	533	41	adaptive	adaptive	ADJ
gs-4321	533	42	phenotypes	phenotype	NOUN
gs-4321	533	43	.	.	PUNCT
gs-4321	534	1	these	these	DET
gs-4321	534	2	ligand	ligand	ADJ
gs-4321	534	3	–	–	PUNCT
gs-4321	534	4	receptor	receptor	NOUN
gs-4321	534	5	axes	axis	NOUN
gs-4321	534	6	have	have	AUX
gs-4321	534	7	been	be	AUX
gs-4321	534	8	repeatedly	repeatedly	ADV
gs-4321	534	9	implicated	implicate	VERB
gs-4321	534	10	in	in	ADP
gs-4321	534	11	stemness	stemness	ADJ
gs-4321	534	12	induction	induction	NOUN
gs-4321	534	13	,	,	PUNCT
gs-4321	534	14	immune	immune	ADJ
gs-4321	534	15	evasion	evasion	NOUN
gs-4321	534	16	,	,	PUNCT
gs-4321	534	17	and	and	CCONJ
gs-4321	534	18	epithelial	epithelial	ADJ
gs-4321	534	19	–	–	PUNCT
gs-4321	534	20	georgian	georgian	NOUN
gs-4321	534	21	scientists/	scientists/	NUM
gs-4321	534	22	.	.	PUNCT
gs-4321	535	1	7	7	NUM
gs-4321	535	2	n	n	DET
gs-4321	535	3	4	4	NUM
gs-4321	535	4	,	,	PUNCT
gs-4321	535	5	2025	2025	NUM
gs-4321	535	6	367	367	NUM
gs-4321	535	7	mesenchymal	mesenchymal	NOUN
gs-4321	535	8	plasticity	plasticity	NOUN
gs-4321	535	9	(	(	PUNCT
gs-4321	535	10	lamouille	lamouille	NOUN
gs-4321	535	11	et	et	PROPN
gs-4321	535	12	al	al	PROPN
gs-4321	535	13	.	.	PROPN
gs-4321	535	14	,	,	PUNCT
gs-4321	535	15	2014	2014	NUM
gs-4321	535	16	;	;	PUNCT
gs-4321	535	17	mani	mani	PROPN
gs-4321	535	18	et	et	PROPN
gs-4321	535	19	al	al	PROPN
gs-4321	535	20	.	.	PROPN
gs-4321	535	21	,	,	PUNCT
gs-4321	535	22	2020	2020	NUM
gs-4321	535	23	)	)	PUNCT
gs-4321	535	24	.	.	PUNCT
gs-4321	536	1	notably	notably	ADV
gs-4321	536	2	,	,	PUNCT
gs-4321	536	3	il-6	il-6	PRON
gs-4321	536	4	/	/	SYM
gs-4321	536	5	stat3	stat3	NOUN
gs-4321	536	6	signaling	signal	VERB
gs-4321	536	7	has	have	AUX
gs-4321	536	8	been	be	AUX
gs-4321	536	9	shown	show	VERB
gs-4321	536	10	to	to	PART
gs-4321	536	11	stabilize	stabilize	VERB
gs-4321	536	12	stress	stress	NOUN
gs-4321	536	13	-	-	PUNCT
gs-4321	536	14	induced	induce	VERB
gs-4321	536	15	reprogramming	reprogramming	NOUN
gs-4321	536	16	,	,	PUNCT
gs-4321	536	17	while	while	SCONJ
gs-4321	536	18	tgf	tgf	PROPN
gs-4321	536	19	signaling	signal	VERB
gs-4321	536	20	promotes	promote	VERB
gs-4321	536	21	partial	partial	ADJ
gs-4321	536	22	emt	emt	NOUN
gs-4321	536	23	and	and	CCONJ
gs-4321	536	24	metastatic	metastatic	ADJ
gs-4321	536	25	potential	potential	NOUN
gs-4321	536	26	through	through	ADP
gs-4321	536	27	modulation	modulation	NOUN
gs-4321	536	28	of	of	ADP
gs-4321	536	29	chromatin	chromatin	NOUN
gs-4321	536	30	accessibility	accessibility	NOUN
gs-4321	536	31	(	(	PUNCT
gs-4321	536	32	nguyen	nguyen	NOUN
gs-4321	536	33	et	et	PROPN
gs-4321	536	34	al	al	PROPN
gs-4321	536	35	.	.	PROPN
gs-4321	536	36	,	,	PUNCT
gs-4321	536	37	2020	2020	NUM
gs-4321	536	38	)	)	PUNCT
gs-4321	536	39	.	.	PUNCT
gs-4321	537	1	the	the	DET
gs-4321	537	2	increasing	increase	VERB
gs-4321	537	3	activity	activity	NOUN
gs-4321	537	4	of	of	ADP
gs-4321	537	5	these	these	DET
gs-4321	537	6	pathways	pathway	NOUN
gs-4321	537	7	along	along	ADP
gs-4321	537	8	pseudotime	pseudotime	ADJ
gs-4321	537	9	trajectories	trajectory	NOUN
gs-4321	537	10	in	in	ADP
gs-4321	537	11	our	our	PRON
gs-4321	537	12	dataset	dataset	NOUN
gs-4321	537	13	suggests	suggest	VERB
gs-4321	537	14	that	that	SCONJ
gs-4321	537	15	microenvironment	microenvironment	NOUN
gs-4321	537	16	-	-	PUNCT
gs-4321	537	17	encoded	encode	VERB
gs-4321	537	18	signals	signal	NOUN
gs-4321	537	19	function	function	VERB
gs-4321	537	20	as	as	ADP
gs-4321	537	21	major	major	ADJ
gs-4321	537	22	determinants	determinant	NOUN
gs-4321	537	23	of	of	ADP
gs-4321	537	24	adaptive	adaptive	ADJ
gs-4321	537	25	trajectories	trajectory	NOUN
gs-4321	537	26	,	,	PUNCT
gs-4321	537	27	reinforcing	reinforce	VERB
gs-4321	537	28	the	the	DET
gs-4321	537	29	emerging	emerge	VERB
gs-4321	537	30	concept	concept	NOUN
gs-4321	537	31	that	that	SCONJ
gs-4321	537	32	plasticity	plasticity	NOUN
gs-4321	537	33	is	be	AUX
gs-4321	537	34	an	an	DET
gs-4321	537	35	ecological	ecological	ADJ
gs-4321	537	36	property	property	NOUN
gs-4321	537	37	mediated	mediate	VERB
gs-4321	537	38	through	through	ADP
gs-4321	537	39	tumor	tumor	NOUN
gs-4321	537	40	–	–	PUNCT
gs-4321	537	41	stroma	stroma	ADJ
gs-4321	537	42	interactions	interaction	NOUN
gs-4321	537	43	.	.	PUNCT
gs-4321	538	1	directional	directional	ADJ
gs-4321	538	2	dynamics	dynamic	NOUN
gs-4321	538	3	suggest	suggest	AUX
gs-4321	538	4	structured	structure	VERB
gs-4321	538	5	adaptive	adaptive	ADJ
gs-4321	538	6	routes	route	NOUN
gs-4321	538	7	the	the	DET
gs-4321	538	8	streamline	streamline	NOUN
gs-4321	538	9	flow	flow	NOUN
gs-4321	538	10	pattern	pattern	NOUN
gs-4321	538	11	observed	observe	VERB
gs-4321	538	12	across	across	ADP
gs-4321	538	13	malignant	malignant	ADJ
gs-4321	538	14	populations	population	NOUN
gs-4321	538	15	is	be	AUX
gs-4321	538	16	consistent	consistent	ADJ
gs-4321	538	17	with	with	ADP
gs-4321	538	18	structured	structure	VERB
gs-4321	538	19	adaptive	adaptive	ADJ
gs-4321	538	20	routes	route	NOUN
gs-4321	538	21	rather	rather	ADV
gs-4321	538	22	than	than	ADP
gs-4321	538	23	stochastic	stochastic	ADJ
gs-4321	538	24	variation	variation	NOUN
gs-4321	538	25	.	.	PUNCT
gs-4321	539	1	similar	similar	ADJ
gs-4321	539	2	directional	directional	ADJ
gs-4321	539	3	dynamics	dynamic	NOUN
gs-4321	539	4	have	have	AUX
gs-4321	539	5	been	be	AUX
gs-4321	539	6	reported	report	VERB
gs-4321	539	7	in	in	ADP
gs-4321	539	8	rna	rna	NOUN
gs-4321	539	9	velocity	velocity	NOUN
gs-4321	539	10	studies	study	NOUN
gs-4321	539	11	of	of	ADP
gs-4321	539	12	melanoma	melanoma	NOUN
gs-4321	539	13	,	,	PUNCT
gs-4321	539	14	glioma	glioma	NOUN
gs-4321	539	15	,	,	PUNCT
gs-4321	539	16	and	and	CCONJ
gs-4321	539	17	lung	lung	NOUN
gs-4321	539	18	cancer	cancer	NOUN
gs-4321	539	19	,	,	PUNCT
gs-4321	539	20	where	where	SCONJ
gs-4321	539	21	cells	cell	NOUN
gs-4321	539	22	follow	follow	VERB
gs-4321	539	23	defined	define	VERB
gs-4321	539	24	routes	route	NOUN
gs-4321	539	25	toward	toward	ADP
gs-4321	539	26	stress	stress	NOUN
gs-4321	539	27	-	-	PUNCT
gs-4321	539	28	tolerant	tolerant	ADJ
gs-4321	539	29	or	or	CCONJ
gs-4321	539	30	dedifferentiated	dedifferentiate	VERB
gs-4321	539	31	phenotypes	phenotype	NOUN
gs-4321	539	32	(	(	PUNCT
gs-4321	539	33	la	la	PROPN
gs-4321	539	34	manno	manno	PROPN
gs-4321	539	35	et	et	PROPN
gs-4321	539	36	al	al	PROPN
gs-4321	539	37	.	.	PROPN
gs-4321	539	38	,	,	PUNCT
gs-4321	539	39	2018	2018	NUM
gs-4321	539	40	;	;	PUNCT
gs-4321	539	41	qiu	qiu	PROPN
gs-4321	539	42	et	et	PROPN
gs-4321	539	43	al	al	PROPN
gs-4321	539	44	.	.	PROPN
gs-4321	539	45	,	,	PUNCT
gs-4321	539	46	2022	2022	NUM
gs-4321	539	47	)	)	PUNCT
gs-4321	539	48	.	.	PUNCT
gs-4321	540	1	this	this	DET
gs-4321	540	2	finding	finding	NOUN
gs-4321	540	3	has	have	VERB
gs-4321	540	4	important	important	ADJ
gs-4321	540	5	implications	implication	NOUN
gs-4321	540	6	for	for	ADP
gs-4321	540	7	therapeutic	therapeutic	ADJ
gs-4321	540	8	design	design	NOUN
gs-4321	540	9	,	,	PUNCT
gs-4321	540	10	as	as	SCONJ
gs-4321	540	11	structured	structured	ADJ
gs-4321	540	12	trajectories	trajectory	NOUN
gs-4321	540	13	suggest	suggest	VERB
gs-4321	540	14	the	the	DET
gs-4321	540	15	existence	existence	NOUN
gs-4321	540	16	of	of	ADP
gs-4321	540	17	predictable	predictable	ADJ
gs-4321	540	18	intermediate	intermediate	ADJ
gs-4321	540	19	states	state	NOUN
gs-4321	540	20	that	that	PRON
gs-4321	540	21	may	may	AUX
gs-4321	540	22	serve	serve	VERB
gs-4321	540	23	as	as	ADP
gs-4321	540	24	intervention	intervention	NOUN
gs-4321	540	25	points	point	NOUN
gs-4321	540	26	.	.	PUNCT
gs-4321	541	1	epigenetic	epigenetic	ADJ
gs-4321	541	2	modulation	modulation	NOUN
gs-4321	541	3	as	as	ADP
gs-4321	541	4	a	a	DET
gs-4321	541	5	foundation	foundation	NOUN
gs-4321	541	6	for	for	ADP
gs-4321	541	7	phenotypic	phenotypic	ADJ
gs-4321	541	8	fluidity	fluidity	NOUN
gs-4321	541	9	our	our	PRON
gs-4321	541	10	findings	finding	NOUN
gs-4321	541	11	align	align	VERB
gs-4321	541	12	with	with	ADP
gs-4321	541	13	previous	previous	ADJ
gs-4321	541	14	work	work	NOUN
gs-4321	541	15	indicating	indicate	VERB
gs-4321	541	16	that	that	SCONJ
gs-4321	541	17	the	the	DET
gs-4321	541	18	epigenome	epigenome	NOUN
gs-4321	541	19	plays	play	VERB
gs-4321	541	20	a	a	DET
gs-4321	541	21	foundational	foundational	ADJ
gs-4321	541	22	role	role	NOUN
gs-4321	541	23	in	in	ADP
gs-4321	541	24	enabling	enable	VERB
gs-4321	541	25	malignant	malignant	ADJ
gs-4321	541	26	cells	cell	NOUN
gs-4321	541	27	to	to	PART
gs-4321	541	28	shift	shift	VERB
gs-4321	541	29	between	between	ADP
gs-4321	541	30	phenotypic	phenotypic	ADJ
gs-4321	541	31	states	state	NOUN
gs-4321	541	32	.	.	PUNCT
gs-4321	542	1	chromatin	chromatin	NOUN
gs-4321	542	2	accessibility	accessibility	NOUN
gs-4321	542	3	profiling	profiling	NOUN
gs-4321	542	4	in	in	ADP
gs-4321	542	5	multiple	multiple	ADJ
gs-4321	542	6	tumor	tumor	NOUN
gs-4321	542	7	types	type	NOUN
gs-4321	542	8	has	have	AUX
gs-4321	542	9	demonstrated	demonstrate	VERB
gs-4321	542	10	that	that	SCONJ
gs-4321	542	11	adaptive	adaptive	ADJ
gs-4321	542	12	populations	population	NOUN
gs-4321	542	13	possess	possess	VERB
gs-4321	542	14	more	more	ADJ
gs-4321	542	15	dynamic	dynamic	ADJ
gs-4321	542	16	enhancer	enhancer	NOUN
gs-4321	542	17	landscapes	landscape	NOUN
gs-4321	542	18	and	and	CCONJ
gs-4321	542	19	increased	increase	VERB
gs-4321	542	20	accessibility	accessibility	NOUN
gs-4321	542	21	at	at	ADP
gs-4321	542	22	motifs	motif	NOUN
gs-4321	542	23	associated	associate	VERB
gs-4321	542	24	with	with	ADP
gs-4321	542	25	stressresponsive	stressresponsive	ADJ
gs-4321	542	26	transcription	transcription	NOUN
gs-4321	542	27	factors	factor	NOUN
gs-4321	542	28	such	such	ADJ
gs-4321	542	29	as	as	ADP
gs-4321	542	30	ap-1	ap-1	NOUN
gs-4321	542	31	,	,	PUNCT
gs-4321	542	32	stat3	stat3	PROPN
gs-4321	542	33	,	,	PUNCT
gs-4321	542	34	nfb	nfb	NOUN
gs-4321	542	35	,	,	PUNCT
gs-4321	542	36	and	and	CCONJ
gs-4321	542	37	atf3	atf3	NOUN
gs-4321	542	38	(	(	PUNCT
gs-4321	542	39	buenrostro	buenrostro	X
gs-4321	542	40	et	et	PROPN
gs-4321	542	41	al	al	PROPN
gs-4321	542	42	.	.	PROPN
gs-4321	542	43	,	,	PUNCT
gs-4321	542	44	2015	2015	NUM
gs-4321	542	45	;	;	PUNCT
gs-4321	542	46	corces	corce	NOUN
gs-4321	542	47	et	et	PROPN
gs-4321	542	48	al	al	PROPN
gs-4321	542	49	.	.	PROPN
gs-4321	542	50	,	,	PUNCT
gs-4321	542	51	2018	2018	NUM
gs-4321	542	52	)	)	PUNCT
gs-4321	542	53	.	.	PUNCT
gs-4321	543	1	the	the	DET
gs-4321	543	2	progressive	progressive	ADJ
gs-4321	543	3	activation	activation	NOUN
gs-4321	543	4	of	of	ADP
gs-4321	543	5	regulators	regulator	NOUN
gs-4321	543	6	observed	observe	VERB
gs-4321	543	7	in	in	ADP
gs-4321	543	8	our	our	PRON
gs-4321	543	9	heatmap	heatmap	NOUN
gs-4321	543	10	analysis	analysis	NOUN
gs-4321	543	11	is	be	AUX
gs-4321	543	12	consistent	consistent	ADJ
gs-4321	543	13	with	with	ADP
gs-4321	543	14	this	this	DET
gs-4321	543	15	epigenetic	epigenetic	ADJ
gs-4321	543	16	permissiveness	permissiveness	NOUN
gs-4321	543	17	.	.	PUNCT
gs-4321	544	1	malignant	malignant	ADJ
gs-4321	544	2	cells	cell	NOUN
gs-4321	544	3	transitioning	transition	VERB
gs-4321	544	4	into	into	ADP
gs-4321	544	5	intermediate	intermediate	ADJ
gs-4321	544	6	or	or	CCONJ
gs-4321	544	7	stem	stem	NOUN
gs-4321	544	8	-	-	PUNCT
gs-4321	544	9	like	like	ADJ
gs-4321	544	10	states	state	NOUN
gs-4321	544	11	likely	likely	ADV
gs-4321	544	12	exploit	exploit	VERB
gs-4321	544	13	these	these	DET
gs-4321	544	14	open	open	ADJ
gs-4321	544	15	chromatin	chromatin	NOUN
gs-4321	544	16	regions	region	NOUN
gs-4321	544	17	to	to	PART
gs-4321	544	18	rapidly	rapidly	ADV
gs-4321	544	19	reorganize	reorganize	VERB
gs-4321	544	20	transcriptional	transcriptional	ADJ
gs-4321	544	21	circuits	circuit	NOUN
gs-4321	544	22	in	in	ADP
gs-4321	544	23	response	response	NOUN
gs-4321	544	24	to	to	ADP
gs-4321	544	25	environmental	environmental	ADJ
gs-4321	544	26	signals	signal	NOUN
gs-4321	544	27	.	.	PUNCT
gs-4321	545	1	this	this	DET
gs-4321	545	2	capacity	capacity	NOUN
gs-4321	545	3	aligns	align	VERB
gs-4321	545	4	with	with	ADP
gs-4321	545	5	data	datum	NOUN
gs-4321	545	6	from	from	ADP
gs-4321	545	7	breast	breast	NOUN
gs-4321	545	8	and	and	CCONJ
gs-4321	545	9	melanoma	melanoma	PROPN
gs-4321	545	10	systems	system	NOUN
gs-4321	545	11	,	,	PUNCT
gs-4321	545	12	where	where	SCONJ
gs-4321	545	13	therapy	therapy	NOUN
gs-4321	545	14	-	-	PUNCT
gs-4321	545	15	induced	induced	ADJ
gs-4321	545	16	reprogramming	reprogramming	NOUN
gs-4321	545	17	is	be	AUX
gs-4321	545	18	driven	drive	VERB
gs-4321	545	19	by	by	ADP
gs-4321	545	20	epigenetic	epigenetic	ADJ
gs-4321	545	21	remodeling	remodeling	NOUN
gs-4321	545	22	at	at	ADP
gs-4321	545	23	key	key	ADJ
gs-4321	545	24	regulatory	regulatory	ADJ
gs-4321	545	25	loci	loci	NOUN
gs-4321	545	26	(	(	PUNCT
gs-4321	545	27	pérez	pérez	NOUN
gs-4321	545	28	-	-	PUNCT
gs-4321	545	29	garcía	garcía	VERB
gs-4321	545	30	et	et	PROPN
gs-4321	545	31	al	al	PROPN
gs-4321	545	32	.	.	PROPN
gs-4321	545	33	,	,	PUNCT
gs-4321	545	34	2022	2022	NUM
gs-4321	545	35	;	;	PUNCT
gs-4321	545	36	tsoi	tsoi	PROPN
gs-4321	545	37	et	et	PROPN
gs-4321	545	38	al	al	PROPN
gs-4321	545	39	.	.	PROPN
gs-4321	545	40	,	,	PUNCT
gs-4321	545	41	2018	2018	NUM
gs-4321	545	42	)	)	PUNCT
gs-4321	545	43	.	.	PUNCT
gs-4321	546	1	together	together	ADV
gs-4321	546	2	,	,	PUNCT
gs-4321	546	3	these	these	DET
gs-4321	546	4	observations	observation	NOUN
gs-4321	546	5	support	support	VERB
gs-4321	546	6	a	a	DET
gs-4321	546	7	model	model	NOUN
gs-4321	546	8	in	in	ADP
gs-4321	546	9	which	which	PRON
gs-4321	546	10	chromatin	chromatin	NOUN
gs-4321	546	11	flexibility	flexibility	NOUN
gs-4321	546	12	acts	act	VERB
gs-4321	546	13	as	as	ADP
gs-4321	546	14	a	a	DET
gs-4321	546	15	substrate	substrate	NOUN
gs-4321	546	16	upon	upon	SCONJ
gs-4321	546	17	which	which	PRON
gs-4321	546	18	transcriptional	transcriptional	ADJ
gs-4321	546	19	reconfiguration	reconfiguration	NOUN
gs-4321	546	20	is	be	AUX
gs-4321	546	21	built	build	VERB
gs-4321	546	22	.	.	PUNCT
gs-4321	547	1	metabolic	metabolic	NOUN
gs-4321	547	2	reprogramming	reprogramming	NOUN
gs-4321	547	3	supports	support	NOUN
gs-4321	547	4	plasticity	plasticity	NOUN
gs-4321	547	5	although	although	SCONJ
gs-4321	547	6	our	our	PRON
gs-4321	547	7	primary	primary	ADJ
gs-4321	547	8	analyses	analysis	NOUN
gs-4321	547	9	focused	focus	VERB
gs-4321	547	10	on	on	ADP
gs-4321	547	11	transcriptional	transcriptional	ADJ
gs-4321	547	12	and	and	CCONJ
gs-4321	547	13	regulatory	regulatory	ADJ
gs-4321	547	14	changes	change	NOUN
gs-4321	548	1	,	,	PUNCT
gs-4321	548	2	previous	previous	ADJ
gs-4321	548	3	studies	study	NOUN
gs-4321	548	4	demonstrate	demonstrate	VERB
gs-4321	548	5	that	that	SCONJ
gs-4321	548	6	metabolic	metabolic	NOUN
gs-4321	548	7	remodeling	remodeling	NOUN
gs-4321	548	8	is	be	AUX
gs-4321	548	9	tightly	tightly	ADV
gs-4321	548	10	intertwined	intertwine	VERB
gs-4321	548	11	with	with	ADP
gs-4321	548	12	adaptive	adaptive	ADJ
gs-4321	548	13	behavior	behavior	NOUN
gs-4321	548	14	.	.	PUNCT
gs-4321	549	1	stress	stress	NOUN
gs-4321	549	2	-	-	PUNCT
gs-4321	549	3	tolerant	tolerant	ADJ
gs-4321	549	4	and	and	CCONJ
gs-4321	549	5	stem	stem	NOUN
gs-4321	549	6	-	-	PUNCT
gs-4321	549	7	like	like	ADJ
gs-4321	549	8	populations	population	NOUN
gs-4321	549	9	often	often	ADV
gs-4321	549	10	display	display	VERB
gs-4321	549	11	shifts	shift	NOUN
gs-4321	549	12	in	in	ADP
gs-4321	549	13	energy	energy	NOUN
gs-4321	549	14	metabolism	metabolism	NOUN
gs-4321	549	15	,	,	PUNCT
gs-4321	549	16	including	include	VERB
gs-4321	549	17	increased	increase	VERB
gs-4321	549	18	dependence	dependence	NOUN
gs-4321	549	19	on	on	ADP
gs-4321	549	20	oxidative	oxidative	ADJ
gs-4321	549	21	phosphorylation	phosphorylation	NOUN
gs-4321	549	22	,	,	PUNCT
gs-4321	549	23	redox	redox	ADJ
gs-4321	549	24	balancing	balancing	NOUN
gs-4321	549	25	,	,	PUNCT
gs-4321	549	26	and	and	CCONJ
gs-4321	549	27	lipid	lipid	NOUN
gs-4321	549	28	metabolism	metabolism	NOUN
gs-4321	549	29	(	(	PUNCT
gs-4321	549	30	faubert	faubert	NOUN
gs-4321	549	31	et	et	PROPN
gs-4321	549	32	al	al	PROPN
gs-4321	549	33	.	.	PROPN
gs-4321	549	34	,	,	PUNCT
gs-4321	549	35	2020	2020	NUM
gs-4321	549	36	;	;	PUNCT
gs-4321	549	37	hangauer	hangauer	NOUN
gs-4321	549	38	et	et	PROPN
gs-4321	549	39	al	al	PROPN
gs-4321	549	40	.	.	PROPN
gs-4321	549	41	,	,	PUNCT
gs-4321	549	42	2017	2017	NUM
gs-4321	549	43	)	)	PUNCT
gs-4321	549	44	.	.	PUNCT
gs-4321	550	1	these	these	DET
gs-4321	550	2	metabolic	metabolic	NOUN
gs-4321	550	3	programs	program	NOUN
gs-4321	550	4	support	support	VERB
gs-4321	550	5	survival	survival	NOUN
gs-4321	550	6	under	under	ADP
gs-4321	550	7	nutrient	nutrient	NOUN
gs-4321	550	8	stress	stress	NOUN
gs-4321	550	9	and	and	CCONJ
gs-4321	550	10	facilitate	facilitate	ADJ
gs-4321	550	11	transitions	transition	NOUN
gs-4321	550	12	into	into	ADP
gs-4321	550	13	low	low	ADJ
gs-4321	550	14	-	-	PUNCT
gs-4321	550	15	proliferative	proliferative	ADJ
gs-4321	550	16	or	or	CCONJ
gs-4321	550	17	therapy	therapy	NOUN
gs-4321	550	18	-	-	PUNCT
gs-4321	550	19	tolerant	tolerant	ADJ
gs-4321	550	20	states	state	NOUN
gs-4321	550	21	.	.	PUNCT
gs-4321	551	1	it	it	PRON
gs-4321	551	2	is	be	AUX
gs-4321	551	3	plausible	plausible	ADJ
gs-4321	551	4	that	that	SCONJ
gs-4321	551	5	the	the	DET
gs-4321	551	6	intermediate	intermediate	ADJ
gs-4321	551	7	and	and	CCONJ
gs-4321	551	8	stemlike	stemlike	ADJ
gs-4321	551	9	states	state	NOUN
gs-4321	551	10	identified	identify	VERB
gs-4321	551	11	in	in	ADP
gs-4321	551	12	our	our	PRON
gs-4321	551	13	analysis	analysis	NOUN
gs-4321	551	14	share	share	VERB
gs-4321	551	15	similar	similar	ADJ
gs-4321	551	16	metabolic	metabolic	NOUN
gs-4321	551	17	features	feature	NOUN
gs-4321	551	18	,	,	PUNCT
gs-4321	551	19	consistent	consistent	ADJ
gs-4321	551	20	with	with	ADP
gs-4321	551	21	the	the	DET
gs-4321	551	22	georgian	georgian	NOUN
gs-4321	551	23	scientists/	scientists/	NUM
gs-4321	551	24	.	.	PUNCT
gs-4321	552	1	7	7	NUM
gs-4321	552	2	n	n	DET
gs-4321	552	3	4	4	NUM
gs-4321	552	4	,	,	PUNCT
gs-4321	552	5	2025	2025	NUM
gs-4321	552	6	368	368	NUM
gs-4321	552	7	metabolic	metabolic	NOUN
gs-4321	552	8	heterogeneity	heterogeneity	NOUN
gs-4321	552	9	documented	document	VERB
gs-4321	552	10	in	in	ADP
gs-4321	552	11	single	single	ADJ
gs-4321	552	12	-	-	PUNCT
gs-4321	552	13	cell	cell	NOUN
gs-4321	552	14	studies	study	NOUN
gs-4321	552	15	across	across	ADP
gs-4321	552	16	several	several	ADJ
gs-4321	552	17	tumor	tumor	NOUN
gs-4321	552	18	types	type	NOUN
gs-4321	552	19	.	.	PUNCT
gs-4321	553	1	future	future	ADJ
gs-4321	553	2	integration	integration	NOUN
gs-4321	553	3	of	of	ADP
gs-4321	553	4	single	single	ADJ
gs-4321	553	5	-	-	PUNCT
gs-4321	553	6	cell	cell	NOUN
gs-4321	553	7	metabolic	metabolic	NOUN
gs-4321	553	8	inference	inference	NOUN
gs-4321	553	9	tools	tool	NOUN
gs-4321	553	10	could	could	AUX
gs-4321	553	11	reveal	reveal	VERB
gs-4321	553	12	a	a	DET
gs-4321	553	13	more	more	ADV
gs-4321	553	14	comprehensive	comprehensive	ADJ
gs-4321	553	15	picture	picture	NOUN
gs-4321	553	16	of	of	ADP
gs-4321	553	17	how	how	SCONJ
gs-4321	553	18	metabolic	metabolic	NOUN
gs-4321	553	19	flux	flux	NOUN
gs-4321	553	20	contributes	contribute	VERB
gs-4321	553	21	to	to	ADP
gs-4321	553	22	state	state	NOUN
gs-4321	553	23	dynamics	dynamic	NOUN
gs-4321	553	24	.	.	PUNCT
gs-4321	554	1	plasticity	plasticity	NOUN
gs-4321	554	2	as	as	ADP
gs-4321	554	3	an	an	DET
gs-4321	554	4	engine	engine	NOUN
gs-4321	554	5	of	of	ADP
gs-4321	554	6	therapeutic	therapeutic	ADJ
gs-4321	554	7	resistance	resistance	NOUN
gs-4321	554	8	the	the	DET
gs-4321	554	9	structured	structured	ADJ
gs-4321	554	10	progression	progression	NOUN
gs-4321	554	11	toward	toward	ADP
gs-4321	554	12	stem	stem	NOUN
gs-4321	554	13	-	-	PUNCT
gs-4321	554	14	like	like	ADJ
gs-4321	554	15	and	and	CCONJ
gs-4321	554	16	stress	stress	NOUN
gs-4321	554	17	-	-	PUNCT
gs-4321	554	18	tolerant	tolerant	ADJ
gs-4321	554	19	phenotypes	phenotype	NOUN
gs-4321	554	20	observed	observe	VERB
gs-4321	554	21	in	in	ADP
gs-4321	554	22	our	our	PRON
gs-4321	554	23	pseudotime	pseudotime	NOUN
gs-4321	554	24	and	and	CCONJ
gs-4321	554	25	streamline	streamline	VERB
gs-4321	554	26	analyses	analysis	NOUN
gs-4321	554	27	provides	provide	VERB
gs-4321	554	28	compelling	compelling	ADJ
gs-4321	554	29	evidence	evidence	NOUN
gs-4321	554	30	that	that	SCONJ
gs-4321	554	31	plasticity	plasticity	NOUN
gs-4321	554	32	is	be	AUX
gs-4321	554	33	a	a	DET
gs-4321	554	34	major	major	ADJ
gs-4321	554	35	driver	driver	NOUN
gs-4321	554	36	of	of	ADP
gs-4321	554	37	therapeutic	therapeutic	ADJ
gs-4321	554	38	resistance	resistance	NOUN
gs-4321	554	39	.	.	PUNCT
gs-4321	555	1	therapy	therapy	NOUN
gs-4321	555	2	-	-	PUNCT
gs-4321	555	3	induced	induce	VERB
gs-4321	555	4	dedifferentiation	dedifferentiation	NOUN
gs-4321	555	5	,	,	PUNCT
gs-4321	555	6	particularly	particularly	ADV
gs-4321	555	7	transitions	transition	NOUN
gs-4321	555	8	toward	toward	ADP
gs-4321	555	9	neural	neural	ADJ
gs-4321	555	10	crest	crest	NOUN
gs-4321	555	11	–	–	PUNCT
gs-4321	555	12	like	like	ADJ
gs-4321	555	13	or	or	CCONJ
gs-4321	555	14	mesenchymal	mesenchymal	NOUN
gs-4321	555	15	-	-	PUNCT
gs-4321	555	16	like	like	ADJ
gs-4321	555	17	states	state	NOUN
gs-4321	555	18	,	,	PUNCT
gs-4321	555	19	has	have	AUX
gs-4321	555	20	been	be	AUX
gs-4321	555	21	reported	report	VERB
gs-4321	555	22	as	as	ADP
gs-4321	555	23	a	a	DET
gs-4321	555	24	resistance	resistance	NOUN
gs-4321	555	25	mechanism	mechanism	NOUN
gs-4321	555	26	in	in	ADP
gs-4321	555	27	melanoma	melanoma	NOUN
gs-4321	555	28	,	,	PUNCT
gs-4321	555	29	lung	lung	NOUN
gs-4321	555	30	cancer	cancer	NOUN
gs-4321	555	31	,	,	PUNCT
gs-4321	555	32	and	and	CCONJ
gs-4321	555	33	prostate	prostate	NOUN
gs-4321	555	34	cancer	cancer	NOUN
gs-4321	555	35	(	(	PUNCT
gs-4321	555	36	boumahdi	boumahdi	NOUN
gs-4321	555	37	and	and	CCONJ
gs-4321	555	38	de	de	X
gs-4321	555	39	sauvage	sauvage	PROPN
gs-4321	555	40	,	,	PUNCT
gs-4321	555	41	2020	2020	NUM
gs-4321	555	42	;	;	PUNCT
gs-4321	555	43	sharma	sharma	PROPN
gs-4321	555	44	et	et	PROPN
gs-4321	555	45	al	al	PROPN
gs-4321	555	46	.	.	PROPN
gs-4321	555	47	,	,	PUNCT
gs-4321	555	48	2010	2010	NUM
gs-4321	555	49	)	)	PUNCT
gs-4321	555	50	.	.	PUNCT
gs-4321	556	1	these	these	DET
gs-4321	556	2	transitions	transition	NOUN
gs-4321	556	3	are	be	AUX
gs-4321	556	4	frequently	frequently	ADV
gs-4321	556	5	reversible	reversible	ADJ
gs-4321	556	6	,	,	PUNCT
gs-4321	556	7	suggesting	suggest	VERB
gs-4321	556	8	that	that	SCONJ
gs-4321	556	9	early	early	ADJ
gs-4321	556	10	intervention	intervention	NOUN
gs-4321	556	11	during	during	ADP
gs-4321	556	12	the	the	DET
gs-4321	556	13	intermediate	intermediate	ADJ
gs-4321	556	14	phase	phase	NOUN
gs-4321	556	15	may	may	AUX
gs-4321	556	16	be	be	AUX
gs-4321	556	17	more	more	ADV
gs-4321	556	18	effective	effective	ADJ
gs-4321	556	19	than	than	ADP
gs-4321	556	20	attempting	attempt	VERB
gs-4321	556	21	to	to	PART
gs-4321	556	22	eliminate	eliminate	VERB
gs-4321	556	23	stable	stable	ADJ
gs-4321	556	24	resistant	resistant	ADJ
gs-4321	556	25	states	state	NOUN
gs-4321	556	26	.	.	PUNCT
gs-4321	557	1	our	our	PRON
gs-4321	557	2	identification	identification	NOUN
gs-4321	557	3	of	of	ADP
gs-4321	557	4	regulatory	regulatory	ADJ
gs-4321	557	5	factors	factor	NOUN
gs-4321	557	6	and	and	CCONJ
gs-4321	557	7	signaling	signal	VERB
gs-4321	557	8	pathways	pathway	NOUN
gs-4321	557	9	enriched	enrich	VERB
gs-4321	557	10	in	in	ADP
gs-4321	557	11	intermediate	intermediate	ADJ
gs-4321	557	12	populations	population	NOUN
gs-4321	557	13	highlights	highlight	VERB
gs-4321	557	14	potential	potential	ADJ
gs-4321	557	15	targets	target	NOUN
gs-4321	557	16	for	for	ADP
gs-4321	557	17	such	such	ADJ
gs-4321	557	18	early	early	ADJ
gs-4321	557	19	intervention	intervention	NOUN
gs-4321	557	20	strategies	strategy	NOUN
gs-4321	557	21	.	.	PUNCT
gs-4321	558	1	importance	importance	NOUN
gs-4321	558	2	of	of	ADP
gs-4321	558	3	microenvironmental	microenvironmental	ADJ
gs-4321	558	4	niches	niche	NOUN
gs-4321	558	5	the	the	DET
gs-4321	558	6	microenvironment	microenvironment	NOUN
gs-4321	558	7	plays	play	VERB
gs-4321	558	8	a	a	DET
gs-4321	558	9	critical	critical	ADJ
gs-4321	558	10	role	role	NOUN
gs-4321	558	11	in	in	ADP
gs-4321	558	12	orchestrating	orchestrate	VERB
gs-4321	558	13	adaptive	adaptive	ADJ
gs-4321	558	14	trajectories	trajectory	NOUN
gs-4321	558	15	.	.	PUNCT
gs-4321	559	1	signals	signal	NOUN
gs-4321	559	2	from	from	ADP
gs-4321	559	3	macrophages	macrophage	NOUN
gs-4321	559	4	,	,	PUNCT
gs-4321	559	5	fibroblasts	fibroblast	NOUN
gs-4321	559	6	,	,	PUNCT
gs-4321	559	7	endothelial	endothelial	ADJ
gs-4321	559	8	cells	cell	NOUN
gs-4321	559	9	,	,	PUNCT
gs-4321	559	10	and	and	CCONJ
gs-4321	559	11	immune	immune	NOUN
gs-4321	559	12	-	-	PUNCT
gs-4321	559	13	infiltrating	infiltrate	VERB
gs-4321	559	14	populations	population	NOUN
gs-4321	559	15	shape	shape	VERB
gs-4321	559	16	malignant	malignant	ADJ
gs-4321	559	17	cell	cell	NOUN
gs-4321	559	18	phenotypes	phenotype	NOUN
gs-4321	559	19	through	through	ADP
gs-4321	559	20	cytokines	cytokine	NOUN
gs-4321	559	21	,	,	PUNCT
gs-4321	559	22	extracellular	extracellular	ADJ
gs-4321	559	23	matrix	matrix	NOUN
gs-4321	559	24	remodeling	remodeling	NOUN
gs-4321	559	25	,	,	PUNCT
gs-4321	559	26	and	and	CCONJ
gs-4321	559	27	metabolic	metabolic	NOUN
gs-4321	559	28	support	support	NOUN
gs-4321	559	29	(	(	PUNCT
gs-4321	559	30	cassetta	cassetta	NOUN
gs-4321	559	31	and	and	CCONJ
gs-4321	559	32	pollard	pollard	NOUN
gs-4321	559	33	,	,	PUNCT
gs-4321	559	34	2020	2020	NUM
gs-4321	559	35	;	;	PUNCT
gs-4321	559	36	glodde	glodde	VERB
gs-4321	559	37	et	et	PROPN
gs-4321	559	38	al	al	PROPN
gs-4321	559	39	.	.	PROPN
gs-4321	559	40	,	,	PUNCT
gs-4321	559	41	2017	2017	NUM
gs-4321	559	42	)	)	PUNCT
gs-4321	559	43	.	.	PUNCT
gs-4321	560	1	the	the	DET
gs-4321	560	2	increasing	increase	VERB
gs-4321	560	3	signaling	signal	VERB
gs-4321	560	4	strength	strength	NOUN
gs-4321	560	5	observed	observe	VERB
gs-4321	560	6	along	along	ADP
gs-4321	560	7	pseudotime	pseudotime	NOUN
gs-4321	560	8	in	in	ADP
gs-4321	560	9	our	our	PRON
gs-4321	560	10	data	datum	NOUN
gs-4321	560	11	strongly	strongly	ADV
gs-4321	560	12	supports	support	VERB
gs-4321	560	13	this	this	DET
gs-4321	560	14	paradigm	paradigm	NOUN
gs-4321	560	15	.	.	PUNCT
gs-4321	561	1	these	these	DET
gs-4321	561	2	findings	finding	NOUN
gs-4321	561	3	reinforce	reinforce	VERB
gs-4321	561	4	the	the	DET
gs-4321	561	5	notion	notion	NOUN
gs-4321	561	6	that	that	SCONJ
gs-4321	561	7	plasticity	plasticity	NOUN
gs-4321	561	8	is	be	AUX
gs-4321	561	9	not	not	PART
gs-4321	561	10	solely	solely	ADV
gs-4321	561	11	an	an	DET
gs-4321	561	12	intrinsic	intrinsic	ADJ
gs-4321	561	13	property	property	NOUN
gs-4321	561	14	but	but	CCONJ
gs-4321	561	15	an	an	DET
gs-4321	561	16	emergent	emergent	ADJ
gs-4321	561	17	behavior	behavior	NOUN
gs-4321	561	18	shaped	shape	VERB
gs-4321	561	19	through	through	ADP
gs-4321	561	20	ecological	ecological	ADJ
gs-4321	561	21	interactions	interaction	NOUN
gs-4321	561	22	.	.	PUNCT
gs-4321	562	1	integration	integration	NOUN
gs-4321	562	2	of	of	ADP
gs-4321	562	3	microenvironmental	microenvironmental	ADJ
gs-4321	562	4	pathways	pathway	NOUN
gs-4321	562	5	with	with	ADP
gs-4321	562	6	regulatory	regulatory	ADJ
gs-4321	562	7	networks	network	NOUN
gs-4321	562	8	our	our	PRON
gs-4321	562	9	findings	finding	NOUN
gs-4321	562	10	underscore	underscore	VERB
gs-4321	562	11	the	the	DET
gs-4321	562	12	tight	tight	ADJ
gs-4321	562	13	integration	integration	NOUN
gs-4321	562	14	between	between	ADP
gs-4321	562	15	microenvironment	microenvironment	NOUN
gs-4321	562	16	-	-	PUNCT
gs-4321	562	17	derived	derive	VERB
gs-4321	562	18	signals	signal	NOUN
gs-4321	562	19	and	and	CCONJ
gs-4321	562	20	transcriptional	transcriptional	ADJ
gs-4321	562	21	regulators	regulator	NOUN
gs-4321	562	22	that	that	PRON
gs-4321	562	23	mediate	mediate	VERB
gs-4321	562	24	plasticity	plasticity	NOUN
gs-4321	562	25	.	.	PUNCT
gs-4321	563	1	for	for	ADP
gs-4321	563	2	example	example	NOUN
gs-4321	563	3	,	,	PUNCT
gs-4321	563	4	il-6	il-6	PRON
gs-4321	563	5	/	/	SYM
gs-4321	563	6	stat3	stat3	NOUN
gs-4321	563	7	signaling	signal	VERB
gs-4321	563	8	has	have	AUX
gs-4321	563	9	been	be	AUX
gs-4321	563	10	shown	show	VERB
gs-4321	563	11	to	to	PART
gs-4321	563	12	directly	directly	ADV
gs-4321	563	13	modulate	modulate	VERB
gs-4321	563	14	chromatin	chromatin	NOUN
gs-4321	563	15	accessibility	accessibility	NOUN
gs-4321	563	16	in	in	ADP
gs-4321	563	17	stem	stem	NOUN
gs-4321	563	18	-	-	PUNCT
gs-4321	563	19	like	like	ADJ
gs-4321	563	20	cells	cell	NOUN
gs-4321	563	21	while	while	SCONJ
gs-4321	563	22	upregulating	upregulating	ADJ
gs-4321	563	23	survival	survival	NOUN
gs-4321	563	24	pathways	pathway	NOUN
gs-4321	563	25	(	(	PUNCT
gs-4321	563	26	nguyen	nguyen	NOUN
gs-4321	563	27	et	et	PROPN
gs-4321	563	28	al	al	PROPN
gs-4321	563	29	.	.	PROPN
gs-4321	563	30	,	,	PUNCT
gs-4321	563	31	2020	2020	NUM
gs-4321	563	32	)	)	PUNCT
gs-4321	563	33	.	.	PUNCT
gs-4321	564	1	meanwhile	meanwhile	ADV
gs-4321	564	2	,	,	PUNCT
gs-4321	564	3	tgf	tgf	PROPN
gs-4321	564	4	–	–	PUNCT
gs-4321	564	5	induced	induced	ADJ
gs-4321	564	6	emt	emt	NOUN
gs-4321	564	7	programs	program	NOUN
gs-4321	564	8	activate	activate	VERB
gs-4321	564	9	zeb1	zeb1	PROPN
gs-4321	564	10	,	,	PUNCT
gs-4321	564	11	which	which	PRON
gs-4321	564	12	reinforces	reinforce	VERB
gs-4321	564	13	lineage	lineage	NOUN
gs-4321	564	14	plasticity	plasticity	NOUN
gs-4321	564	15	and	and	CCONJ
gs-4321	564	16	promotes	promote	VERB
gs-4321	564	17	metastasis	metastasis	NOUN
gs-4321	564	18	(	(	PUNCT
gs-4321	564	19	lamouille	lamouille	VERB
gs-4321	564	20	et	et	PROPN
gs-4321	564	21	al	al	PROPN
gs-4321	564	22	.	.	PROPN
gs-4321	564	23	,	,	PUNCT
gs-4321	564	24	2014	2014	NUM
gs-4321	564	25	)	)	PUNCT
gs-4321	564	26	.	.	PUNCT
gs-4321	565	1	the	the	DET
gs-4321	565	2	convergence	convergence	NOUN
gs-4321	565	3	of	of	ADP
gs-4321	565	4	these	these	DET
gs-4321	565	5	pathways	pathway	NOUN
gs-4321	565	6	in	in	ADP
gs-4321	565	7	our	our	PRON
gs-4321	565	8	stem	stem	NOUN
gs-4321	565	9	-	-	PUNCT
gs-4321	565	10	like	like	ADJ
gs-4321	565	11	cluster	cluster	NOUN
gs-4321	565	12	suggests	suggest	VERB
gs-4321	565	13	that	that	SCONJ
gs-4321	565	14	multiple	multiple	ADJ
gs-4321	565	15	microenvironmental	microenvironmental	ADJ
gs-4321	565	16	cues	cue	NOUN
gs-4321	565	17	simultaneously	simultaneously	ADV
gs-4321	565	18	act	act	VERB
gs-4321	565	19	to	to	PART
gs-4321	565	20	shape	shape	VERB
gs-4321	565	21	resilient	resilient	ADJ
gs-4321	565	22	cell	cell	NOUN
gs-4321	565	23	states	state	NOUN
gs-4321	565	24	.	.	PUNCT
gs-4321	566	1	this	this	DET
gs-4321	566	2	interplay	interplay	NOUN
gs-4321	566	3	is	be	AUX
gs-4321	566	4	consistent	consistent	ADJ
gs-4321	566	5	with	with	ADP
gs-4321	566	6	previous	previous	ADJ
gs-4321	566	7	work	work	NOUN
gs-4321	566	8	showing	show	VERB
gs-4321	566	9	that	that	SCONJ
gs-4321	566	10	combined	combine	VERB
gs-4321	566	11	inflammatory	inflammatory	ADJ
gs-4321	566	12	and	and	CCONJ
gs-4321	566	13	stromal	stromal	ADJ
gs-4321	566	14	cues	cue	NOUN
gs-4321	566	15	create	create	VERB
gs-4321	566	16	highly	highly	ADV
gs-4321	566	17	plastic	plastic	ADJ
gs-4321	566	18	niches	niche	NOUN
gs-4321	566	19	,	,	PUNCT
gs-4321	566	20	particularly	particularly	ADV
gs-4321	566	21	in	in	ADP
gs-4321	566	22	advanced	advanced	ADJ
gs-4321	566	23	tumors	tumor	NOUN
gs-4321	566	24	(	(	PUNCT
gs-4321	566	25	jerby	jerby	NOUN
gs-4321	566	26	-	-	PUNCT
gs-4321	566	27	arnon	arnon	PROPN
gs-4321	566	28	et	et	PROPN
gs-4321	566	29	al	al	PROPN
gs-4321	566	30	.	.	PROPN
gs-4321	566	31	,	,	PUNCT
gs-4321	566	32	2018	2018	NUM
gs-4321	566	33	)	)	PUNCT
gs-4321	566	34	.	.	PUNCT
gs-4321	567	1	conserved	conserve	VERB
gs-4321	567	2	plasticity	plasticity	NOUN
gs-4321	567	3	programs	program	NOUN
gs-4321	567	4	across	across	ADP
gs-4321	567	5	tumor	tumor	NOUN
gs-4321	567	6	types	type	NOUN
gs-4321	567	7	the	the	DET
gs-4321	567	8	reproducibility	reproducibility	NOUN
gs-4321	567	9	of	of	ADP
gs-4321	567	10	differentiated	differentiated	ADJ
gs-4321	567	11	,	,	PUNCT
gs-4321	567	12	intermediate	intermediate	ADJ
gs-4321	567	13	,	,	PUNCT
gs-4321	567	14	and	and	CCONJ
gs-4321	567	15	stem	stem	NOUN
gs-4321	567	16	-	-	PUNCT
gs-4321	567	17	like	like	ADJ
gs-4321	567	18	states	state	NOUN
gs-4321	567	19	across	across	ADP
gs-4321	567	20	datasets	dataset	NOUN
gs-4321	567	21	from	from	ADP
gs-4321	567	22	different	different	ADJ
gs-4321	567	23	tumor	tumor	NOUN
gs-4321	567	24	types	type	NOUN
gs-4321	567	25	suggests	suggest	VERB
gs-4321	567	26	that	that	SCONJ
gs-4321	567	27	plasticity	plasticity	NOUN
gs-4321	567	28	is	be	AUX
gs-4321	567	29	governed	govern	VERB
gs-4321	567	30	by	by	ADP
gs-4321	567	31	conserved	conserve	VERB
gs-4321	567	32	cellular	cellular	ADJ
gs-4321	567	33	programs	program	NOUN
gs-4321	567	34	rather	rather	ADV
gs-4321	567	35	than	than	ADP
gs-4321	567	36	tumor	tumor	NOUN
gs-4321	567	37	-	-	PUNCT
gs-4321	567	38	specific	specific	ADJ
gs-4321	567	39	mechanisms	mechanism	NOUN
gs-4321	567	40	.	.	PUNCT
gs-4321	568	1	similar	similar	ADJ
gs-4321	568	2	three	three	NUM
gs-4321	568	3	-	-	PUNCT
gs-4321	568	4	state	state	NOUN
gs-4321	568	5	structures	structure	NOUN
gs-4321	568	6	have	have	AUX
gs-4321	568	7	been	be	AUX
gs-4321	568	8	described	describe	VERB
gs-4321	568	9	in	in	ADP
gs-4321	568	10	melanoma	melanoma	NOUN
gs-4321	568	11	,	,	PUNCT
gs-4321	568	12	glioblastoma	glioblastoma	NOUN
gs-4321	568	13	,	,	PUNCT
gs-4321	568	14	pancreatic	pancreatic	ADJ
gs-4321	568	15	cancer	cancer	NOUN
gs-4321	568	16	,	,	PUNCT
gs-4321	568	17	and	and	CCONJ
gs-4321	568	18	colorectal	colorectal	ADJ
gs-4321	568	19	carcinoma	carcinoma	NOUN
gs-4321	568	20	(	(	PUNCT
gs-4321	568	21	neftel	neftel	NOUN
gs-4321	568	22	et	et	PROPN
gs-4321	568	23	al	al	PROPN
gs-4321	568	24	.	.	PROPN
gs-4321	568	25	,	,	PUNCT
gs-4321	568	26	2019	2019	NUM
gs-4321	568	27	;	;	PUNCT
gs-4321	568	28	georgian	georgian	PROPN
gs-4321	568	29	scientists/	scientists/	NUM
gs-4321	568	30	.	.	PUNCT
gs-4321	569	1	7	7	NUM
gs-4321	569	2	n	n	DET
gs-4321	569	3	4	4	NUM
gs-4321	569	4	,	,	PUNCT
gs-4321	569	5	2025	2025	NUM
gs-4321	569	6	369	369	NUM
gs-4321	569	7	kim	kim	PROPN
gs-4321	569	8	et	et	PROPN
gs-4321	569	9	al	al	PROPN
gs-4321	569	10	.	.	PROPN
gs-4321	569	11	,	,	PUNCT
gs-4321	569	12	2020	2020	NUM
gs-4321	569	13	)	)	PUNCT
gs-4321	569	14	.	.	PUNCT
gs-4321	570	1	this	this	DET
gs-4321	570	2	conservation	conservation	NOUN
gs-4321	570	3	implies	imply	VERB
gs-4321	570	4	that	that	SCONJ
gs-4321	570	5	plasticity	plasticity	NOUN
gs-4321	570	6	reflects	reflect	VERB
gs-4321	570	7	a	a	DET
gs-4321	570	8	general	general	ADJ
gs-4321	570	9	evolutionary	evolutionary	ADJ
gs-4321	570	10	strategy	strategy	NOUN
gs-4321	570	11	used	use	VERB
gs-4321	570	12	by	by	ADP
gs-4321	570	13	malignant	malignant	ADJ
gs-4321	570	14	cells	cell	NOUN
gs-4321	570	15	to	to	PART
gs-4321	570	16	maximize	maximize	VERB
gs-4321	570	17	adaptability	adaptability	NOUN
gs-4321	570	18	in	in	ADP
gs-4321	570	19	heterogeneous	heterogeneous	ADJ
gs-4321	570	20	environments	environment	NOUN
gs-4321	570	21	.	.	PUNCT
gs-4321	571	1	these	these	DET
gs-4321	571	2	findings	finding	NOUN
gs-4321	571	3	also	also	ADV
gs-4321	571	4	support	support	VERB
gs-4321	571	5	the	the	DET
gs-4321	571	6	applicability	applicability	NOUN
gs-4321	571	7	of	of	ADP
gs-4321	571	8	cross	cross	ADJ
gs-4321	571	9	-	-	ADJ
gs-4321	571	10	tumor	tumor	ADJ
gs-4321	571	11	interventions	intervention	NOUN
gs-4321	571	12	targeting	target	VERB
gs-4321	571	13	plasticity	plasticity	NOUN
gs-4321	571	14	-	-	PUNCT
gs-4321	571	15	associated	associate	VERB
gs-4321	571	16	pathways	pathway	NOUN
gs-4321	571	17	.	.	PUNCT
gs-4321	572	1	evolutionary	evolutionary	ADJ
gs-4321	572	2	implications	implication	NOUN
gs-4321	572	3	of	of	ADP
gs-4321	572	4	state	state	NOUN
gs-4321	572	5	transitions	transition	NOUN
gs-4321	572	6	the	the	DET
gs-4321	572	7	directional	directional	ADJ
gs-4321	572	8	progression	progression	NOUN
gs-4321	572	9	observed	observe	VERB
gs-4321	572	10	in	in	ADP
gs-4321	572	11	our	our	PRON
gs-4321	572	12	analyses	analysis	NOUN
gs-4321	572	13	supports	support	VERB
gs-4321	572	14	evolutionary	evolutionary	ADJ
gs-4321	572	15	models	model	NOUN
gs-4321	572	16	in	in	ADP
gs-4321	572	17	which	which	PRON
gs-4321	572	18	plasticity	plasticity	NOUN
gs-4321	572	19	enhances	enhance	VERB
gs-4321	572	20	tumor	tumor	NOUN
gs-4321	572	21	fitness	fitness	NOUN
gs-4321	572	22	by	by	ADP
gs-4321	572	23	enabling	enable	VERB
gs-4321	572	24	cells	cell	NOUN
gs-4321	572	25	to	to	PART
gs-4321	572	26	explore	explore	VERB
gs-4321	572	27	advantageous	advantageous	ADJ
gs-4321	572	28	phenotypes	phenotype	NOUN
gs-4321	572	29	.	.	PUNCT
gs-4321	573	1	this	this	DET
gs-4321	573	2	concept	concept	NOUN
gs-4321	573	3	is	be	AUX
gs-4321	573	4	consistent	consistent	ADJ
gs-4321	573	5	with	with	ADP
gs-4321	573	6	clonal	clonal	ADJ
gs-4321	573	7	evolution	evolution	NOUN
gs-4321	573	8	frameworks	framework	NOUN
gs-4321	573	9	that	that	PRON
gs-4321	573	10	incorporate	incorporate	VERB
gs-4321	573	11	both	both	CCONJ
gs-4321	573	12	genetic	genetic	ADJ
gs-4321	573	13	and	and	CCONJ
gs-4321	573	14	non	non	ADJ
gs-4321	573	15	-	-	ADJ
gs-4321	573	16	genetic	genetic	ADJ
gs-4321	573	17	sources	source	NOUN
gs-4321	573	18	of	of	ADP
gs-4321	573	19	diversity	diversity	NOUN
gs-4321	573	20	(	(	PUNCT
gs-4321	573	21	francis	francis	PROPN
gs-4321	573	22	et	et	PROPN
gs-4321	573	23	al	al	PROPN
gs-4321	573	24	.	.	PROPN
gs-4321	573	25	,	,	PUNCT
gs-4321	573	26	2019	2019	NUM
gs-4321	573	27	)	)	PUNCT
gs-4321	573	28	.	.	PUNCT
gs-4321	574	1	intermediate	intermediate	ADJ
gs-4321	574	2	states	state	NOUN
gs-4321	574	3	may	may	AUX
gs-4321	574	4	serve	serve	VERB
gs-4321	574	5	as	as	ADP
gs-4321	574	6	evolutionary	evolutionary	ADJ
gs-4321	574	7	intermediates	intermediate	NOUN
gs-4321	574	8	,	,	PUNCT
gs-4321	574	9	enabling	enable	VERB
gs-4321	574	10	malignant	malignant	ADJ
gs-4321	574	11	cells	cell	NOUN
gs-4321	574	12	to	to	PART
gs-4321	574	13	rapidly	rapidly	ADV
gs-4321	574	14	respond	respond	VERB
gs-4321	574	15	to	to	ADP
gs-4321	574	16	stress	stress	NOUN
gs-4321	574	17	while	while	SCONJ
gs-4321	574	18	maintaining	maintain	VERB
gs-4321	574	19	the	the	DET
gs-4321	574	20	capacity	capacity	NOUN
gs-4321	574	21	to	to	PART
gs-4321	574	22	revert	revert	VERB
gs-4321	574	23	or	or	CCONJ
gs-4321	574	24	differentiate	differentiate	VERB
gs-4321	574	25	depending	depend	VERB
gs-4321	574	26	on	on	ADP
gs-4321	574	27	environmental	environmental	ADJ
gs-4321	574	28	conditions	condition	NOUN
gs-4321	574	29	.	.	PUNCT
gs-4321	575	1	studies	study	NOUN
gs-4321	575	2	in	in	ADP
gs-4321	575	3	leukemia	leukemia	NOUN
gs-4321	575	4	and	and	CCONJ
gs-4321	575	5	melanoma	melanoma	NOUN
gs-4321	575	6	have	have	AUX
gs-4321	575	7	shown	show	VERB
gs-4321	575	8	that	that	SCONJ
gs-4321	575	9	plasticity	plasticity	NOUN
gs-4321	575	10	accelerates	accelerate	VERB
gs-4321	575	11	adaptation	adaptation	NOUN
gs-4321	575	12	under	under	ADP
gs-4321	575	13	drug	drug	NOUN
gs-4321	575	14	pressure	pressure	NOUN
gs-4321	575	15	and	and	CCONJ
gs-4321	575	16	increases	increase	VERB
gs-4321	575	17	the	the	DET
gs-4321	575	18	likelihood	likelihood	NOUN
gs-4321	575	19	of	of	ADP
gs-4321	575	20	acquiring	acquire	VERB
gs-4321	575	21	genetic	genetic	ADJ
gs-4321	575	22	resistance	resistance	NOUN
gs-4321	575	23	mutations	mutation	NOUN
gs-4321	575	24	(	(	PUNCT
gs-4321	575	25	wu	wu	PROPN
gs-4321	575	26	et	et	PROPN
gs-4321	575	27	al	al	PROPN
gs-4321	575	28	.	.	PROPN
gs-4321	575	29	,	,	PUNCT
gs-4321	575	30	2020	2020	NUM
gs-4321	575	31	;	;	PUNCT
gs-4321	575	32	dagogo	dagogo	NOUN
gs-4321	575	33	-	-	PUNCT
gs-4321	575	34	jack	jack	PROPN
gs-4321	575	35	and	and	CCONJ
gs-4321	575	36	shaw	shaw	PROPN
gs-4321	575	37	,	,	PUNCT
gs-4321	575	38	2018	2018	NUM
gs-4321	575	39	)	)	PUNCT
gs-4321	575	40	.	.	PUNCT
gs-4321	576	1	our	our	PRON
gs-4321	576	2	findings	finding	NOUN
gs-4321	576	3	fit	fit	VERB
gs-4321	576	4	well	well	ADV
gs-4321	576	5	within	within	ADP
gs-4321	576	6	this	this	DET
gs-4321	576	7	model	model	NOUN
gs-4321	576	8	.	.	PUNCT
gs-4321	577	1	therapeutic	therapeutic	ADJ
gs-4321	577	2	opportunities	opportunity	NOUN
gs-4321	577	3	targeting	target	VERB
gs-4321	577	4	plasticity	plasticity	NOUN
gs-4321	577	5	given	give	VERB
gs-4321	577	6	the	the	DET
gs-4321	577	7	central	central	ADJ
gs-4321	577	8	role	role	NOUN
gs-4321	577	9	of	of	ADP
gs-4321	577	10	plasticity	plasticity	NOUN
gs-4321	577	11	in	in	ADP
gs-4321	577	12	promoting	promote	VERB
gs-4321	577	13	survival	survival	NOUN
gs-4321	577	14	and	and	CCONJ
gs-4321	577	15	resistance	resistance	NOUN
gs-4321	577	16	,	,	PUNCT
gs-4321	577	17	targeting	target	VERB
gs-4321	577	18	the	the	DET
gs-4321	577	19	molecular	molecular	ADJ
gs-4321	577	20	mechanisms	mechanism	NOUN
gs-4321	577	21	underlying	underlie	VERB
gs-4321	577	22	state	state	NOUN
gs-4321	577	23	transitions	transition	NOUN
gs-4321	577	24	represents	represent	VERB
gs-4321	577	25	a	a	DET
gs-4321	577	26	promising	promising	ADJ
gs-4321	577	27	therapeutic	therapeutic	ADJ
gs-4321	577	28	strategy	strategy	NOUN
gs-4321	577	29	.	.	PUNCT
gs-4321	578	1	potential	potential	ADJ
gs-4321	578	2	approaches	approach	NOUN
gs-4321	578	3	include	include	VERB
gs-4321	578	4	inhibition	inhibition	NOUN
gs-4321	578	5	of	of	ADP
gs-4321	578	6	chromatin	chromatin	NOUN
gs-4321	578	7	remodelers	remodeler	NOUN
gs-4321	578	8	,	,	PUNCT
gs-4321	578	9	blockade	blockade	NOUN
gs-4321	578	10	of	of	ADP
gs-4321	578	11	key	key	ADJ
gs-4321	578	12	microenvironmental	microenvironmental	ADJ
gs-4321	578	13	signaling	signal	VERB
gs-4321	578	14	axes	axis	NOUN
gs-4321	578	15	,	,	PUNCT
gs-4321	578	16	and	and	CCONJ
gs-4321	578	17	disruption	disruption	NOUN
gs-4321	578	18	of	of	ADP
gs-4321	578	19	master	master	NOUN
gs-4321	578	20	regulatory	regulatory	ADJ
gs-4321	578	21	transcription	transcription	NOUN
gs-4321	578	22	factors	factor	NOUN
gs-4321	578	23	.	.	PUNCT
gs-4321	579	1	for	for	ADP
gs-4321	579	2	example	example	NOUN
gs-4321	579	3	,	,	PUNCT
gs-4321	579	4	inhibitors	inhibitor	NOUN
gs-4321	579	5	of	of	ADP
gs-4321	579	6	bet	bet	ADJ
gs-4321	579	7	proteins	protein	NOUN
gs-4321	579	8	,	,	PUNCT
gs-4321	579	9	hdacs	hdac	NOUN
gs-4321	579	10	,	,	PUNCT
gs-4321	579	11	and	and	CCONJ
gs-4321	579	12	ezh2	ezh2	PROPN
gs-4321	579	13	have	have	AUX
gs-4321	579	14	shown	show	VERB
gs-4321	579	15	efficacy	efficacy	NOUN
gs-4321	579	16	in	in	ADP
gs-4321	579	17	suppressing	suppress	VERB
gs-4321	579	18	lineage	lineage	NOUN
gs-4321	579	19	plasticity	plasticity	NOUN
gs-4321	579	20	and	and	CCONJ
gs-4321	579	21	restoring	restore	VERB
gs-4321	579	22	sensitivity	sensitivity	NOUN
gs-4321	579	23	to	to	ADP
gs-4321	579	24	targeted	target	VERB
gs-4321	579	25	therapies	therapy	NOUN
gs-4321	579	26	(	(	PUNCT
gs-4321	579	27	su	su	PROPN
gs-4321	579	28	et	et	PROPN
gs-4321	579	29	al	al	PROPN
gs-4321	579	30	.	.	PROPN
gs-4321	579	31	,	,	PUNCT
gs-4321	579	32	2020	2020	NUM
gs-4321	579	33	;	;	PUNCT
gs-4321	579	34	liau	liau	NOUN
gs-4321	579	35	et	et	PROPN
gs-4321	579	36	al	al	PROPN
gs-4321	579	37	.	.	PROPN
gs-4321	579	38	,	,	PUNCT
gs-4321	579	39	2017	2017	NUM
gs-4321	579	40	)	)	PUNCT
gs-4321	579	41	.	.	PUNCT
gs-4321	580	1	similarly	similarly	ADV
gs-4321	580	2	,	,	PUNCT
gs-4321	580	3	targeting	target	VERB
gs-4321	580	4	il-6	il-6	NOUN
gs-4321	580	5	/	/	SYM
gs-4321	580	6	stat3	stat3	NOUN
gs-4321	580	7	or	or	CCONJ
gs-4321	580	8	tgf	tgf	PROPN
gs-4321	580	9	signaling	signaling	NOUN
gs-4321	580	10	has	have	AUX
gs-4321	580	11	been	be	AUX
gs-4321	580	12	proposed	propose	VERB
gs-4321	580	13	as	as	ADP
gs-4321	580	14	a	a	DET
gs-4321	580	15	strategy	strategy	NOUN
gs-4321	580	16	to	to	PART
gs-4321	580	17	reduce	reduce	VERB
gs-4321	580	18	adaptive	adaptive	ADJ
gs-4321	580	19	reprogramming	reprogramme	VERB
gs-4321	580	20	(	(	PUNCT
gs-4321	580	21	nguyen	nguyen	NOUN
gs-4321	580	22	et	et	PROPN
gs-4321	580	23	al	al	PROPN
gs-4321	580	24	.	.	PROPN
gs-4321	580	25	,	,	PUNCT
gs-4321	580	26	2020	2020	NUM
gs-4321	580	27	)	)	PUNCT
gs-4321	580	28	.	.	PUNCT
gs-4321	581	1	the	the	DET
gs-4321	581	2	identification	identification	NOUN
gs-4321	581	3	of	of	ADP
gs-4321	581	4	intermediate	intermediate	ADJ
gs-4321	581	5	populations	population	NOUN
gs-4321	581	6	in	in	ADP
gs-4321	581	7	our	our	PRON
gs-4321	581	8	study	study	NOUN
gs-4321	581	9	highlights	highlight	VERB
gs-4321	581	10	the	the	DET
gs-4321	581	11	potential	potential	NOUN
gs-4321	581	12	for	for	ADP
gs-4321	581	13	therapeutically	therapeutically	ADV
gs-4321	581	14	targeting	target	VERB
gs-4321	581	15	transitional	transitional	ADJ
gs-4321	581	16	states	state	NOUN
gs-4321	581	17	before	before	ADP
gs-4321	581	18	stable	stable	ADJ
gs-4321	581	19	resistant	resistant	ADJ
gs-4321	581	20	phenotypes	phenotype	NOUN
gs-4321	581	21	emerge	emerge	VERB
gs-4321	581	22	.	.	PUNCT
gs-4321	582	1	limitations	limitation	NOUN
gs-4321	582	2	of	of	ADP
gs-4321	582	3	transcriptional	transcriptional	ADJ
gs-4321	582	4	state	state	NOUN
gs-4321	582	5	inference	inference	NOUN
gs-4321	582	6	while	while	SCONJ
gs-4321	582	7	our	our	PRON
gs-4321	582	8	analysis	analysis	NOUN
gs-4321	582	9	provides	provide	VERB
gs-4321	582	10	strong	strong	ADJ
gs-4321	582	11	evidence	evidence	NOUN
gs-4321	582	12	for	for	ADP
gs-4321	582	13	structured	structure	VERB
gs-4321	582	14	adaptive	adaptive	ADJ
gs-4321	582	15	trajectories	trajectory	NOUN
gs-4321	582	16	,	,	PUNCT
gs-4321	582	17	several	several	ADJ
gs-4321	582	18	limitations	limitation	NOUN
gs-4321	582	19	should	should	AUX
gs-4321	582	20	be	be	AUX
gs-4321	582	21	considered	consider	VERB
gs-4321	582	22	.	.	PUNCT
gs-4321	583	1	first	first	ADV
gs-4321	583	2	,	,	PUNCT
gs-4321	583	3	transcriptional	transcriptional	ADJ
gs-4321	583	4	measurements	measurement	NOUN
gs-4321	583	5	capture	capture	VERB
gs-4321	583	6	only	only	ADV
gs-4321	583	7	one	one	NUM
gs-4321	583	8	layer	layer	NOUN
gs-4321	583	9	of	of	ADP
gs-4321	583	10	cellular	cellular	ADJ
gs-4321	583	11	identity	identity	NOUN
gs-4321	583	12	,	,	PUNCT
gs-4321	583	13	and	and	CCONJ
gs-4321	583	14	do	do	AUX
gs-4321	583	15	not	not	PART
gs-4321	583	16	fully	fully	ADV
gs-4321	583	17	capture	capture	VERB
gs-4321	583	18	post	post	ADJ
gs-4321	583	19	-	-	ADJ
gs-4321	583	20	transcriptional	transcriptional	ADJ
gs-4321	583	21	,	,	PUNCT
gs-4321	583	22	proteomic	proteomic	NOUN
gs-4321	583	23	,	,	PUNCT
gs-4321	583	24	or	or	CCONJ
gs-4321	583	25	metabolic	metabolic	NOUN
gs-4321	583	26	regulation	regulation	NOUN
gs-4321	583	27	.	.	PUNCT
gs-4321	584	1	although	although	SCONJ
gs-4321	584	2	regulatory	regulatory	ADJ
gs-4321	584	3	network	network	NOUN
gs-4321	584	4	inference	inference	NOUN
gs-4321	584	5	offers	offer	VERB
gs-4321	584	6	insight	insight	NOUN
gs-4321	584	7	into	into	ADP
gs-4321	584	8	transcription	transcription	NOUN
gs-4321	584	9	factor	factor	NOUN
gs-4321	584	10	activity	activity	NOUN
gs-4321	584	11	,	,	PUNCT
gs-4321	584	12	direct	direct	ADJ
gs-4321	584	13	protein	protein	NOUN
gs-4321	584	14	-	-	PUNCT
gs-4321	584	15	level	level	NOUN
gs-4321	584	16	measurements	measurement	NOUN
gs-4321	584	17	are	be	AUX
gs-4321	584	18	needed	need	VERB
gs-4321	584	19	to	to	PART
gs-4321	584	20	validate	validate	VERB
gs-4321	584	21	key	key	ADJ
gs-4321	584	22	regulatory	regulatory	ADJ
gs-4321	584	23	events	event	NOUN
gs-4321	584	24	.	.	PUNCT
gs-4321	585	1	single	single	ADJ
gs-4321	585	2	-	-	PUNCT
gs-4321	585	3	cell	cell	NOUN
gs-4321	585	4	proteomics	proteomic	NOUN
gs-4321	585	5	technologies	technology	NOUN
gs-4321	585	6	are	be	AUX
gs-4321	585	7	rapidly	rapidly	ADV
gs-4321	585	8	improving	improve	VERB
gs-4321	585	9	but	but	CCONJ
gs-4321	585	10	still	still	ADV
gs-4321	585	11	lack	lack	VERB
gs-4321	585	12	the	the	DET
gs-4321	585	13	resolution	resolution	NOUN
gs-4321	585	14	of	of	ADP
gs-4321	585	15	transcriptomic	transcriptomic	ADJ
gs-4321	585	16	methods	method	NOUN
gs-4321	585	17	(	(	PUNCT
gs-4321	585	18	chevrier	chevrier	NOUN
gs-4321	585	19	et	et	PROPN
gs-4321	585	20	al	al	PROPN
gs-4321	585	21	.	.	PROPN
gs-4321	585	22	,	,	PUNCT
gs-4321	585	23	2018	2018	NUM
gs-4321	585	24	)	)	PUNCT
gs-4321	585	25	.	.	PUNCT
gs-4321	586	1	additionally	additionally	ADV
gs-4321	586	2	,	,	PUNCT
gs-4321	586	3	transcriptional	transcriptional	ADJ
gs-4321	586	4	noise	noise	NOUN
gs-4321	586	5	and	and	CCONJ
gs-4321	586	6	dropout	dropout	NOUN
gs-4321	586	7	effects	effect	NOUN
gs-4321	586	8	inherent	inherent	ADJ
gs-4321	586	9	to	to	PART
gs-4321	586	10	scrna	scrna	VERB
gs-4321	586	11	-	-	PUNCT
gs-4321	586	12	seq	seq	NOUN
gs-4321	586	13	may	may	AUX
gs-4321	586	14	obscure	obscure	VERB
gs-4321	586	15	rare	rare	ADJ
gs-4321	586	16	subpopulations	subpopulation	NOUN
gs-4321	586	17	or	or	CCONJ
gs-4321	586	18	create	create	VERB
gs-4321	586	19	artifacts	artifact	NOUN
gs-4321	586	20	in	in	ADP
gs-4321	586	21	lineage	lineage	NOUN
gs-4321	586	22	reconstruction	reconstruction	NOUN
gs-4321	586	23	.	.	PUNCT
gs-4321	587	1	data	datum	NOUN
gs-4321	587	2	integration	integration	NOUN
gs-4321	587	3	across	across	ADP
gs-4321	587	4	datasets	dataset	NOUN
gs-4321	587	5	our	our	PRON
gs-4321	587	6	study	study	NOUN
gs-4321	587	7	integrates	integrate	VERB
gs-4321	587	8	datasets	dataset	NOUN
gs-4321	587	9	from	from	ADP
gs-4321	587	10	multiple	multiple	ADJ
gs-4321	587	11	tumor	tumor	NOUN
gs-4321	587	12	types	type	NOUN
gs-4321	587	13	and	and	CCONJ
gs-4321	587	14	platforms	platform	NOUN
gs-4321	587	15	,	,	PUNCT
gs-4321	587	16	introducing	introduce	VERB
gs-4321	587	17	potential	potential	ADJ
gs-4321	587	18	batch	batch	NOUN
gs-4321	587	19	effects	effect	NOUN
gs-4321	587	20	that	that	PRON
gs-4321	587	21	may	may	AUX
gs-4321	587	22	influence	influence	VERB
gs-4321	587	23	downstream	downstream	ADJ
gs-4321	587	24	analyses	analysis	NOUN
gs-4321	587	25	.	.	PUNCT
gs-4321	588	1	while	while	SCONJ
gs-4321	588	2	we	we	PRON
gs-4321	588	3	employed	employ	VERB
gs-4321	588	4	robust	robust	ADJ
gs-4321	588	5	georgian	georgian	NOUN
gs-4321	588	6	scientists/	scientists/	NUM
gs-4321	588	7	.	.	PUNCT
gs-4321	589	1	7	7	NUM
gs-4321	589	2	n	n	DET
gs-4321	589	3	4	4	NUM
gs-4321	589	4	,	,	PUNCT
gs-4321	589	5	2025	2025	NUM
gs-4321	589	6	370	370	NUM
gs-4321	589	7	integration	integration	NOUN
gs-4321	589	8	methods	method	NOUN
gs-4321	589	9	such	such	ADJ
gs-4321	589	10	as	as	ADP
gs-4321	589	11	harmony	harmony	NOUN
gs-4321	589	12	and	and	CCONJ
gs-4321	589	13	mutual	mutual	ADJ
gs-4321	589	14	nearest	near	ADJ
gs-4321	589	15	neighbors	neighbor	NOUN
gs-4321	589	16	,	,	PUNCT
gs-4321	589	17	complete	complete	ADJ
gs-4321	589	18	removal	removal	NOUN
gs-4321	589	19	of	of	ADP
gs-4321	589	20	dataset	dataset	NOUN
gs-4321	589	21	-	-	PUNCT
gs-4321	589	22	specific	specific	ADJ
gs-4321	589	23	signatures	signature	NOUN
gs-4321	589	24	remains	remain	VERB
gs-4321	589	25	challenging	challenging	ADJ
gs-4321	589	26	.	.	PUNCT
gs-4321	590	1	nonetheless	nonetheless	ADV
gs-4321	590	2	,	,	PUNCT
gs-4321	590	3	the	the	DET
gs-4321	590	4	reproducibility	reproducibility	NOUN
gs-4321	590	5	of	of	ADP
gs-4321	590	6	major	major	ADJ
gs-4321	590	7	cell	cell	NOUN
gs-4321	590	8	-	-	PUNCT
gs-4321	590	9	state	state	NOUN
gs-4321	590	10	structures	structure	NOUN
gs-4321	590	11	across	across	ADP
gs-4321	590	12	datasets	dataset	NOUN
gs-4321	590	13	suggests	suggest	VERB
gs-4321	590	14	that	that	SCONJ
gs-4321	590	15	the	the	DET
gs-4321	590	16	observed	observed	ADJ
gs-4321	590	17	patterns	pattern	NOUN
gs-4321	590	18	reflect	reflect	VERB
gs-4321	590	19	biological	biological	ADJ
gs-4321	590	20	phenomena	phenomenon	NOUN
gs-4321	590	21	rather	rather	ADV
gs-4321	590	22	than	than	ADP
gs-4321	590	23	integration	integration	NOUN
gs-4321	590	24	artifacts	artifact	NOUN
gs-4321	590	25	.	.	PUNCT
gs-4321	591	1	future	future	ADJ
gs-4321	591	2	work	work	NOUN
gs-4321	591	3	using	use	VERB
gs-4321	591	4	jointly	jointly	ADV
gs-4321	591	5	profiled	profile	VERB
gs-4321	591	6	single	single	ADJ
gs-4321	591	7	-	-	PUNCT
gs-4321	591	8	cell	cell	NOUN
gs-4321	591	9	multiomic	multiomic	ADJ
gs-4321	591	10	datasets	dataset	NOUN
gs-4321	591	11	may	may	AUX
gs-4321	591	12	help	help	VERB
gs-4321	591	13	reduce	reduce	VERB
gs-4321	591	14	these	these	DET
gs-4321	591	15	limitations	limitation	NOUN
gs-4321	591	16	.	.	PUNCT
gs-4321	592	1	interpretation	interpretation	NOUN
gs-4321	592	2	of	of	ADP
gs-4321	592	3	streamline	streamline	NOUN
gs-4321	592	4	-	-	PUNCT
gs-4321	592	5	based	base	VERB
gs-4321	592	6	transitions	transition	NOUN
gs-4321	592	7	the	the	DET
gs-4321	592	8	streamline	streamline	VERB
gs-4321	592	9	analysis	analysis	NOUN
gs-4321	592	10	used	use	VERB
gs-4321	592	11	to	to	PART
gs-4321	592	12	infer	infer	VERB
gs-4321	592	13	dynamic	dynamic	ADJ
gs-4321	592	14	transitions	transition	NOUN
gs-4321	592	15	provides	provide	VERB
gs-4321	592	16	a	a	DET
gs-4321	592	17	conceptual	conceptual	ADJ
gs-4321	592	18	model	model	NOUN
gs-4321	592	19	for	for	ADP
gs-4321	592	20	state	state	NOUN
gs-4321	592	21	progression	progression	NOUN
gs-4321	592	22	,	,	PUNCT
gs-4321	592	23	but	but	CCONJ
gs-4321	592	24	does	do	AUX
gs-4321	592	25	not	not	PART
gs-4321	592	26	directly	directly	ADV
gs-4321	592	27	measure	measure	VERB
gs-4321	592	28	transcriptional	transcriptional	ADJ
gs-4321	592	29	kinetics	kinetic	NOUN
gs-4321	592	30	in	in	ADP
gs-4321	592	31	the	the	DET
gs-4321	592	32	same	same	ADJ
gs-4321	592	33	way	way	NOUN
gs-4321	592	34	as	as	ADP
gs-4321	592	35	rna	rna	NOUN
gs-4321	592	36	velocity	velocity	NOUN
gs-4321	592	37	.	.	PUNCT
gs-4321	593	1	thus	thus	ADV
gs-4321	593	2	,	,	PUNCT
gs-4321	593	3	while	while	SCONJ
gs-4321	593	4	the	the	DET
gs-4321	593	5	observed	observed	ADJ
gs-4321	593	6	directional	directional	ADJ
gs-4321	593	7	trends	trend	NOUN
gs-4321	593	8	are	be	AUX
gs-4321	593	9	highly	highly	ADV
gs-4321	593	10	consistent	consistent	ADJ
gs-4321	593	11	with	with	ADP
gs-4321	593	12	prior	prior	ADJ
gs-4321	593	13	velocity	velocity	NOUN
gs-4321	593	14	-	-	PUNCT
gs-4321	593	15	based	base	VERB
gs-4321	593	16	studies	study	NOUN
gs-4321	593	17	,	,	PUNCT
gs-4321	593	18	they	they	PRON
gs-4321	593	19	should	should	AUX
gs-4321	593	20	be	be	AUX
gs-4321	593	21	interpreted	interpret	VERB
gs-4321	593	22	as	as	ADP
gs-4321	593	23	approximations	approximation	NOUN
gs-4321	593	24	rather	rather	ADV
gs-4321	593	25	than	than	ADP
gs-4321	593	26	precise	precise	ADJ
gs-4321	593	27	trajectory	trajectory	NOUN
gs-4321	593	28	reconstructions	reconstruction	NOUN
gs-4321	593	29	(	(	PUNCT
gs-4321	593	30	la	la	X
gs-4321	593	31	manno	manno	PROPN
gs-4321	593	32	et	et	PROPN
gs-4321	593	33	al	al	PROPN
gs-4321	593	34	.	.	PROPN
gs-4321	593	35	,	,	PUNCT
gs-4321	593	36	2018	2018	NUM
gs-4321	593	37	)	)	PUNCT
gs-4321	593	38	.	.	PUNCT
gs-4321	594	1	additional	additional	ADJ
gs-4321	594	2	integration	integration	NOUN
gs-4321	594	3	with	with	ADP
gs-4321	594	4	temporal	temporal	ADJ
gs-4321	594	5	or	or	CCONJ
gs-4321	594	6	perturbation	perturbation	NOUN
gs-4321	594	7	-	-	PUNCT
gs-4321	594	8	based	base	VERB
gs-4321	594	9	single	single	ADJ
gs-4321	594	10	-	-	PUNCT
gs-4321	594	11	cell	cell	NOUN
gs-4321	594	12	datasets	dataset	NOUN
gs-4321	594	13	may	may	AUX
gs-4321	594	14	enhance	enhance	VERB
gs-4321	594	15	the	the	DET
gs-4321	594	16	fidelity	fidelity	NOUN
gs-4321	594	17	of	of	ADP
gs-4321	594	18	these	these	DET
gs-4321	594	19	inferred	infer	VERB
gs-4321	594	20	routes	route	NOUN
gs-4321	594	21	.	.	PUNCT
gs-4321	595	1	lack	lack	NOUN
gs-4321	595	2	of	of	ADP
gs-4321	595	3	spatial	spatial	ADJ
gs-4321	595	4	context	context	NOUN
gs-4321	595	5	although	although	SCONJ
gs-4321	595	6	our	our	PRON
gs-4321	595	7	signaling	signal	VERB
gs-4321	595	8	analysis	analysis	NOUN
gs-4321	595	9	implicates	implicate	VERB
gs-4321	595	10	several	several	ADJ
gs-4321	595	11	microenvironmental	microenvironmental	ADJ
gs-4321	595	12	pathways	pathway	NOUN
gs-4321	595	13	in	in	ADP
gs-4321	595	14	shaping	shape	VERB
gs-4321	595	15	plasticity	plasticity	NOUN
gs-4321	595	16	,	,	PUNCT
gs-4321	595	17	the	the	DET
gs-4321	595	18	absence	absence	NOUN
gs-4321	595	19	of	of	ADP
gs-4321	595	20	directly	directly	ADV
gs-4321	595	21	integrated	integrate	VERB
gs-4321	595	22	spatial	spatial	ADJ
gs-4321	595	23	transcriptomic	transcriptomic	ADJ
gs-4321	595	24	data	datum	NOUN
gs-4321	595	25	limits	limit	VERB
gs-4321	595	26	our	our	PRON
gs-4321	595	27	ability	ability	NOUN
gs-4321	595	28	to	to	PART
gs-4321	595	29	identify	identify	VERB
gs-4321	595	30	niche	niche	NOUN
gs-4321	595	31	-	-	PUNCT
gs-4321	595	32	specific	specific	ADJ
gs-4321	595	33	regulators	regulator	NOUN
gs-4321	595	34	.	.	PUNCT
gs-4321	596	1	spatial	spatial	ADJ
gs-4321	596	2	technologies	technology	NOUN
gs-4321	596	3	such	such	ADJ
gs-4321	596	4	as	as	ADP
gs-4321	596	5	10x	10x	PROPN
gs-4321	596	6	visium	visium	PROPN
gs-4321	596	7	,	,	PUNCT
gs-4321	596	8	slideseq	slideseq	NOUN
gs-4321	596	9	,	,	PUNCT
gs-4321	596	10	merfish	merfish	NOUN
gs-4321	596	11	,	,	PUNCT
gs-4321	596	12	and	and	CCONJ
gs-4321	596	13	nanostring	nanostre	VERB
gs-4321	596	14	cosmx	cosmx	NOUN
gs-4321	596	15	have	have	AUX
gs-4321	596	16	revealed	reveal	VERB
gs-4321	596	17	that	that	SCONJ
gs-4321	596	18	plasticity	plasticity	NOUN
gs-4321	596	19	is	be	AUX
gs-4321	596	20	often	often	ADV
gs-4321	596	21	spatially	spatially	ADV
gs-4321	596	22	restricted	restrict	VERB
gs-4321	596	23	to	to	ADP
gs-4321	596	24	particular	particular	ADJ
gs-4321	596	25	microenvironmental	microenvironmental	ADJ
gs-4321	596	26	niches	niche	NOUN
gs-4321	596	27	(	(	PUNCT
gs-4321	596	28	jensen	jensen	PROPN
gs-4321	596	29	et	et	PROPN
gs-4321	596	30	al	al	PROPN
gs-4321	596	31	.	.	PROPN
gs-4321	596	32	,	,	PUNCT
gs-4321	596	33	2021	2021	NUM
gs-4321	596	34	)	)	PUNCT
gs-4321	596	35	.	.	PUNCT
gs-4321	597	1	integrating	integrate	VERB
gs-4321	597	2	spatial	spatial	ADJ
gs-4321	597	3	position	position	NOUN
gs-4321	597	4	with	with	ADP
gs-4321	597	5	single	single	ADJ
gs-4321	597	6	-	-	PUNCT
gs-4321	597	7	cell	cell	NOUN
gs-4321	597	8	state	state	NOUN
gs-4321	597	9	information	information	NOUN
gs-4321	597	10	would	would	AUX
gs-4321	597	11	provide	provide	VERB
gs-4321	597	12	a	a	DET
gs-4321	597	13	more	more	ADV
gs-4321	597	14	complete	complete	ADJ
gs-4321	597	15	understanding	understanding	NOUN
gs-4321	597	16	of	of	ADP
gs-4321	597	17	how	how	SCONJ
gs-4321	597	18	local	local	ADJ
gs-4321	597	19	stimuli	stimulus	NOUN
gs-4321	597	20	influence	influence	VERB
gs-4321	597	21	adaptive	adaptive	ADJ
gs-4321	597	22	behavior	behavior	NOUN
gs-4321	597	23	.	.	PUNCT
gs-4321	598	1	genetic	genetic	ADJ
gs-4321	598	2	factors	factor	NOUN
gs-4321	598	3	not	not	PART
gs-4321	598	4	explicitly	explicitly	ADV
gs-4321	598	5	modeled	model	VERB
gs-4321	598	6	while	while	SCONJ
gs-4321	598	7	plasticity	plasticity	NOUN
gs-4321	598	8	is	be	AUX
gs-4321	598	9	strongly	strongly	ADV
gs-4321	598	10	driven	drive	VERB
gs-4321	598	11	by	by	ADP
gs-4321	598	12	non	non	ADJ
gs-4321	598	13	-	-	ADJ
gs-4321	598	14	genetic	genetic	ADJ
gs-4321	598	15	factors	factor	NOUN
gs-4321	598	16	,	,	PUNCT
gs-4321	598	17	genetic	genetic	ADJ
gs-4321	598	18	alterations	alteration	NOUN
gs-4321	598	19	also	also	ADV
gs-4321	598	20	play	play	VERB
gs-4321	598	21	important	important	ADJ
gs-4321	598	22	roles	role	NOUN
gs-4321	598	23	in	in	ADP
gs-4321	598	24	shaping	shape	VERB
gs-4321	598	25	adaptive	adaptive	ADJ
gs-4321	598	26	capacity	capacity	NOUN
gs-4321	598	27	.	.	PUNCT
gs-4321	599	1	our	our	PRON
gs-4321	599	2	study	study	NOUN
gs-4321	599	3	did	do	AUX
gs-4321	599	4	not	not	PART
gs-4321	599	5	explicitly	explicitly	ADV
gs-4321	599	6	integrate	integrate	VERB
gs-4321	599	7	singlecell	singlecell	PROPN
gs-4321	599	8	dna	dna	PROPN
gs-4321	599	9	data	data	PROPN
gs-4321	599	10	,	,	PUNCT
gs-4321	599	11	which	which	PRON
gs-4321	599	12	could	could	AUX
gs-4321	599	13	reveal	reveal	VERB
gs-4321	599	14	how	how	SCONJ
gs-4321	599	15	mutations	mutation	NOUN
gs-4321	599	16	interact	interact	VERB
gs-4321	599	17	with	with	ADP
gs-4321	599	18	lineage	lineage	NOUN
gs-4321	599	19	plasticity	plasticity	NOUN
gs-4321	599	20	.	.	PUNCT
gs-4321	600	1	recent	recent	ADJ
gs-4321	600	2	work	work	NOUN
gs-4321	600	3	demonstrates	demonstrate	VERB
gs-4321	600	4	that	that	SCONJ
gs-4321	600	5	mutations	mutation	NOUN
gs-4321	600	6	in	in	ADP
gs-4321	600	7	chromatin	chromatin	NOUN
gs-4321	600	8	remodelers	remodeler	NOUN
gs-4321	600	9	,	,	PUNCT
gs-4321	600	10	tp53	tp53	PROPN
gs-4321	600	11	,	,	PUNCT
gs-4321	600	12	and	and	CCONJ
gs-4321	600	13	swi	swi	PROPN
gs-4321	600	14	/	/	SYM
gs-4321	600	15	snf	snf	PROPN
gs-4321	600	16	components	component	NOUN
gs-4321	600	17	increase	increase	VERB
gs-4321	600	18	transcriptional	transcriptional	ADJ
gs-4321	600	19	entropy	entropy	NOUN
gs-4321	600	20	and	and	CCONJ
gs-4321	600	21	promote	promote	VERB
gs-4321	600	22	lineage	lineage	NOUN
gs-4321	600	23	transitions	transition	NOUN
gs-4321	600	24	(	(	PUNCT
gs-4321	600	25	rheinbay	rheinbay	PROPN
gs-4321	600	26	et	et	PROPN
gs-4321	600	27	al	al	PROPN
gs-4321	600	28	.	.	PROPN
gs-4321	600	29	,	,	PUNCT
gs-4321	600	30	2020	2020	NUM
gs-4321	600	31	)	)	PUNCT
gs-4321	600	32	.	.	PUNCT
gs-4321	601	1	incorporating	incorporate	VERB
gs-4321	601	2	clonal	clonal	ADJ
gs-4321	601	3	architecture	architecture	NOUN
gs-4321	601	4	into	into	ADP
gs-4321	601	5	future	future	ADJ
gs-4321	601	6	analyses	analysis	NOUN
gs-4321	601	7	would	would	AUX
gs-4321	601	8	clarify	clarify	VERB
gs-4321	601	9	how	how	SCONJ
gs-4321	601	10	genetics	genetic	NOUN
gs-4321	601	11	and	and	CCONJ
gs-4321	601	12	plasticity	plasticity	NOUN
gs-4321	601	13	intersect	intersect	ADJ
gs-4321	601	14	.	.	PUNCT
gs-4321	602	1	the	the	DET
gs-4321	602	2	ecological	ecological	ADJ
gs-4321	602	3	nature	nature	NOUN
gs-4321	602	4	of	of	ADP
gs-4321	602	5	plasticity	plasticity	NOUN
gs-4321	602	6	one	one	NUM
gs-4321	602	7	of	of	ADP
gs-4321	602	8	the	the	DET
gs-4321	602	9	most	most	ADV
gs-4321	602	10	significant	significant	ADJ
gs-4321	602	11	implications	implication	NOUN
gs-4321	602	12	of	of	ADP
gs-4321	602	13	our	our	PRON
gs-4321	602	14	findings	finding	NOUN
gs-4321	602	15	is	be	AUX
gs-4321	602	16	that	that	SCONJ
gs-4321	602	17	adaptive	adaptive	ADJ
gs-4321	602	18	behavior	behavior	NOUN
gs-4321	602	19	in	in	ADP
gs-4321	602	20	cancer	cancer	NOUN
gs-4321	602	21	should	should	AUX
gs-4321	602	22	be	be	AUX
gs-4321	602	23	understood	understand	VERB
gs-4321	602	24	as	as	ADP
gs-4321	602	25	an	an	DET
gs-4321	602	26	ecological	ecological	ADJ
gs-4321	602	27	phenomenon	phenomenon	NOUN
gs-4321	602	28	rather	rather	ADV
gs-4321	602	29	than	than	ADP
gs-4321	602	30	an	an	DET
gs-4321	602	31	intrinsic	intrinsic	ADJ
gs-4321	602	32	cellular	cellular	ADJ
gs-4321	602	33	trait	trait	NOUN
gs-4321	602	34	.	.	PUNCT
gs-4321	603	1	malignant	malignant	ADJ
gs-4321	603	2	cells	cell	NOUN
gs-4321	603	3	respond	respond	VERB
gs-4321	603	4	to	to	ADP
gs-4321	603	5	signals	signal	NOUN
gs-4321	603	6	from	from	ADP
gs-4321	603	7	surrounding	surround	VERB
gs-4321	603	8	stromal	stromal	ADJ
gs-4321	603	9	,	,	PUNCT
gs-4321	603	10	immune	immune	ADJ
gs-4321	603	11	,	,	PUNCT
gs-4321	603	12	and	and	CCONJ
gs-4321	603	13	endothelial	endothelial	ADJ
gs-4321	603	14	compartments	compartment	NOUN
gs-4321	603	15	,	,	PUNCT
gs-4321	603	16	and	and	CCONJ
gs-4321	603	17	plasticity	plasticity	NOUN
gs-4321	603	18	emerges	emerge	VERB
gs-4321	603	19	through	through	ADP
gs-4321	603	20	these	these	DET
gs-4321	603	21	interactions	interaction	NOUN
gs-4321	603	22	.	.	PUNCT
gs-4321	604	1	this	this	DET
gs-4321	604	2	ecological	ecological	ADJ
gs-4321	604	3	perspective	perspective	NOUN
gs-4321	604	4	aligns	align	VERB
gs-4321	604	5	with	with	ADP
gs-4321	604	6	recent	recent	ADJ
gs-4321	604	7	studies	study	NOUN
gs-4321	604	8	that	that	PRON
gs-4321	604	9	highlight	highlight	VERB
gs-4321	604	10	the	the	DET
gs-4321	604	11	importance	importance	NOUN
gs-4321	604	12	of	of	ADP
gs-4321	604	13	tumor	tumor	NOUN
gs-4321	604	14	microenvironments	microenvironment	NOUN
gs-4321	604	15	in	in	ADP
gs-4321	604	16	shaping	shape	VERB
gs-4321	604	17	therapy	therapy	NOUN
gs-4321	604	18	resistance	resistance	NOUN
gs-4321	604	19	and	and	CCONJ
gs-4321	604	20	metastatic	metastatic	ADJ
gs-4321	604	21	progression	progression	NOUN
gs-4321	604	22	(	(	PUNCT
gs-4321	604	23	cassetta	cassetta	NOUN
gs-4321	604	24	and	and	CCONJ
gs-4321	604	25	pollard	pollard	NOUN
gs-4321	604	26	,	,	PUNCT
gs-4321	604	27	2020	2020	NUM
gs-4321	604	28	;	;	PUNCT
gs-4321	604	29	glodde	glodde	VERB
gs-4321	604	30	et	et	PROPN
gs-4321	604	31	al	al	PROPN
gs-4321	604	32	.	.	PROPN
gs-4321	604	33	,	,	PUNCT
gs-4321	604	34	2017	2017	NUM
gs-4321	604	35	)	)	PUNCT
gs-4321	604	36	.	.	PUNCT
gs-4321	605	1	interventions	intervention	NOUN
gs-4321	605	2	aimed	aim	VERB
gs-4321	605	3	at	at	ADP
gs-4321	605	4	modifying	modify	VERB
gs-4321	605	5	the	the	DET
gs-4321	605	6	microenvironment	microenvironment	NOUN
gs-4321	605	7	—	—	PUNCT
gs-4321	605	8	such	such	ADJ
gs-4321	605	9	as	as	ADP
gs-4321	605	10	altering	alter	VERB
gs-4321	605	11	cytokine	cytokine	ADJ
gs-4321	605	12	gradients	gradient	NOUN
gs-4321	605	13	or	or	CCONJ
gs-4321	605	14	remodeling	remodel	VERB
gs-4321	605	15	extracellular	extracellular	ADJ
gs-4321	605	16	matrix	matrix	NOUN
gs-4321	605	17	components	component	NOUN
gs-4321	605	18	—	—	PUNCT
gs-4321	605	19	may	may	AUX
gs-4321	605	20	therefore	therefore	ADV
gs-4321	605	21	reduce	reduce	VERB
gs-4321	605	22	the	the	DET
gs-4321	605	23	selective	selective	ADJ
gs-4321	605	24	pressures	pressure	NOUN
gs-4321	605	25	that	that	PRON
gs-4321	605	26	drive	drive	VERB
gs-4321	605	27	adaptive	adaptive	ADJ
gs-4321	605	28	transitions	transition	NOUN
gs-4321	605	29	.	.	PUNCT
gs-4321	606	1	georgian	georgian	NOUN
gs-4321	606	2	scientists/	scientists/	NUM
gs-4321	606	3	.	.	PUNCT
gs-4321	607	1	7	7	NUM
gs-4321	607	2	n	n	DET
gs-4321	607	3	4	4	NUM
gs-4321	607	4	,	,	PUNCT
gs-4321	607	5	2025	2025	NUM
gs-4321	607	6	371	371	NUM
gs-4321	607	7	role	role	NOUN
gs-4321	607	8	of	of	ADP
gs-4321	607	9	immune	immune	NOUN
gs-4321	607	10	-	-	PUNCT
gs-4321	607	11	mediated	mediate	VERB
gs-4321	607	12	stress	stress	NOUN
gs-4321	607	13	immune	immune	ADJ
gs-4321	607	14	engagement	engagement	NOUN
gs-4321	607	15	often	often	ADV
gs-4321	607	16	induces	induce	VERB
gs-4321	607	17	phenotypic	phenotypic	ADJ
gs-4321	607	18	changes	change	NOUN
gs-4321	607	19	associated	associate	VERB
gs-4321	607	20	with	with	ADP
gs-4321	607	21	adaptation	adaptation	NOUN
gs-4321	607	22	.	.	PUNCT
gs-4321	608	1	for	for	ADP
gs-4321	608	2	example	example	NOUN
gs-4321	608	3	,	,	PUNCT
gs-4321	608	4	ifn	ifn	PROPN
gs-4321	608	5	exposure	exposure	NOUN
gs-4321	608	6	induces	induce	VERB
gs-4321	608	7	dedifferentiation	dedifferentiation	NOUN
gs-4321	608	8	in	in	ADP
gs-4321	608	9	melanoma	melanoma	NOUN
gs-4321	608	10	,	,	PUNCT
gs-4321	608	11	leading	lead	VERB
gs-4321	608	12	to	to	ADP
gs-4321	608	13	reduced	reduce	VERB
gs-4321	608	14	antigen	antigen	ADJ
gs-4321	608	15	presentation	presentation	NOUN
gs-4321	608	16	and	and	CCONJ
gs-4321	608	17	increased	increase	VERB
gs-4321	608	18	therapy	therapy	NOUN
gs-4321	608	19	resistance	resistance	NOUN
gs-4321	608	20	(	(	PUNCT
gs-4321	608	21	benci	benci	PROPN
gs-4321	608	22	et	et	PROPN
gs-4321	608	23	al	al	PROPN
gs-4321	608	24	.	.	PROPN
gs-4321	608	25	,	,	PUNCT
gs-4321	608	26	2016	2016	NUM
gs-4321	608	27	)	)	PUNCT
gs-4321	608	28	.	.	PUNCT
gs-4321	609	1	our	our	PRON
gs-4321	609	2	observation	observation	NOUN
gs-4321	609	3	of	of	ADP
gs-4321	609	4	increasing	increase	VERB
gs-4321	609	5	signaling	signal	VERB
gs-4321	609	6	activity	activity	NOUN
gs-4321	609	7	along	along	ADP
gs-4321	609	8	pseudotime	pseudotime	ADJ
gs-4321	609	9	trajectories	trajectory	NOUN
gs-4321	609	10	suggests	suggest	VERB
gs-4321	609	11	that	that	SCONJ
gs-4321	609	12	immunemediated	immunemediate	VERB
gs-4321	609	13	stress	stress	NOUN
gs-4321	609	14	may	may	AUX
gs-4321	609	15	contribute	contribute	VERB
gs-4321	609	16	to	to	ADP
gs-4321	609	17	the	the	DET
gs-4321	609	18	progression	progression	NOUN
gs-4321	609	19	toward	toward	ADP
gs-4321	609	20	stem	stem	NOUN
gs-4321	609	21	-	-	PUNCT
gs-4321	609	22	like	like	ADJ
gs-4321	609	23	states	state	NOUN
gs-4321	609	24	.	.	PUNCT
gs-4321	610	1	this	this	DET
gs-4321	610	2	finding	finding	NOUN
gs-4321	610	3	supports	support	VERB
gs-4321	610	4	the	the	DET
gs-4321	610	5	idea	idea	NOUN
gs-4321	610	6	that	that	SCONJ
gs-4321	610	7	immunotherapies	immunotherapy	NOUN
gs-4321	610	8	may	may	AUX
gs-4321	610	9	inadvertently	inadvertently	ADV
gs-4321	610	10	select	select	VERB
gs-4321	610	11	for	for	ADP
gs-4321	610	12	more	more	ADV
gs-4321	610	13	resilient	resilient	ADJ
gs-4321	610	14	phenotypes	phenotype	NOUN
gs-4321	610	15	if	if	SCONJ
gs-4321	610	16	not	not	PART
gs-4321	610	17	combined	combine	VERB
gs-4321	610	18	with	with	ADP
gs-4321	610	19	strategies	strategy	NOUN
gs-4321	610	20	that	that	PRON
gs-4321	610	21	target	target	VERB
gs-4321	610	22	plasticity	plasticity	NOUN
gs-4321	610	23	.	.	PUNCT
gs-4321	611	1	the	the	DET
gs-4321	611	2	temporal	temporal	ADJ
gs-4321	611	3	dynamics	dynamic	NOUN
gs-4321	611	4	of	of	ADP
gs-4321	611	5	plasticity	plasticity	NOUN
gs-4321	611	6	plasticity	plasticity	NOUN
gs-4321	611	7	is	be	AUX
gs-4321	611	8	a	a	DET
gs-4321	611	9	dynamic	dynamic	ADJ
gs-4321	611	10	process	process	NOUN
gs-4321	611	11	that	that	PRON
gs-4321	611	12	evolves	evolve	VERB
gs-4321	611	13	over	over	ADP
gs-4321	611	14	time	time	NOUN
gs-4321	611	15	,	,	PUNCT
gs-4321	611	16	and	and	CCONJ
gs-4321	611	17	our	our	PRON
gs-4321	611	18	streamline	streamline	ADV
gs-4321	611	19	-	-	PUNCT
gs-4321	611	20	based	base	VERB
gs-4321	611	21	analysis	analysis	NOUN
gs-4321	611	22	captures	capture	VERB
gs-4321	611	23	this	this	DET
gs-4321	611	24	temporal	temporal	ADJ
gs-4321	611	25	progression	progression	NOUN
gs-4321	611	26	.	.	PUNCT
gs-4321	612	1	intermediate	intermediate	ADJ
gs-4321	612	2	states	state	NOUN
gs-4321	612	3	appear	appear	VERB
gs-4321	612	4	to	to	PART
gs-4321	612	5	represent	represent	VERB
gs-4321	612	6	temporally	temporally	ADV
gs-4321	612	7	transient	transient	ADJ
gs-4321	612	8	configurations	configuration	NOUN
gs-4321	612	9	that	that	PRON
gs-4321	612	10	bridge	bridge	NOUN
gs-4321	612	11	differentiated	differentiated	ADJ
gs-4321	612	12	and	and	CCONJ
gs-4321	612	13	stem	stem	NOUN
gs-4321	612	14	-	-	PUNCT
gs-4321	612	15	like	like	ADJ
gs-4321	612	16	identities	identity	NOUN
gs-4321	612	17	.	.	PUNCT
gs-4321	613	1	data	datum	NOUN
gs-4321	613	2	from	from	ADP
gs-4321	613	3	melanoma	melanoma	NOUN
gs-4321	613	4	,	,	PUNCT
gs-4321	613	5	glioblastoma	glioblastoma	NOUN
gs-4321	613	6	,	,	PUNCT
gs-4321	613	7	and	and	CCONJ
gs-4321	613	8	leukemia	leukemia	NOUN
gs-4321	613	9	demonstrate	demonstrate	VERB
gs-4321	613	10	that	that	SCONJ
gs-4321	613	11	such	such	ADJ
gs-4321	613	12	transitions	transition	NOUN
gs-4321	613	13	may	may	AUX
gs-4321	613	14	occur	occur	AUX
gs-4321	613	15	rapidly	rapidly	ADV
gs-4321	613	16	following	follow	VERB
gs-4321	613	17	therapy	therapy	NOUN
gs-4321	613	18	exposure	exposure	NOUN
gs-4321	613	19	(	(	PUNCT
gs-4321	613	20	sharma	sharma	PROPN
gs-4321	613	21	et	et	PROPN
gs-4321	613	22	al	al	PROPN
gs-4321	613	23	.	.	PROPN
gs-4321	613	24	,	,	PUNCT
gs-4321	613	25	2010	2010	NUM
gs-4321	613	26	;	;	PUNCT
gs-4321	613	27	wu	wu	PROPN
gs-4321	613	28	et	et	PROPN
gs-4321	613	29	al	al	PROPN
gs-4321	613	30	.	.	PROPN
gs-4321	613	31	,	,	PUNCT
gs-4321	613	32	2020	2020	NUM
gs-4321	613	33	)	)	PUNCT
gs-4321	613	34	.	.	PUNCT
gs-4321	614	1	targeting	target	VERB
gs-4321	614	2	transient	transient	ADJ
gs-4321	614	3	intermediates	intermediate	NOUN
gs-4321	614	4	during	during	ADP
gs-4321	614	5	these	these	DET
gs-4321	614	6	windows	window	NOUN
gs-4321	614	7	of	of	ADP
gs-4321	614	8	vulnerability	vulnerability	NOUN
gs-4321	614	9	may	may	AUX
gs-4321	614	10	improve	improve	VERB
gs-4321	614	11	therapeutic	therapeutic	ADJ
gs-4321	614	12	outcomes	outcome	NOUN
gs-4321	614	13	.	.	PUNCT
gs-4321	615	1	cross	cross	ADJ
gs-4321	615	2	-	-	ADJ
gs-4321	615	3	tumor	tumor	ADJ
gs-4321	615	4	similarities	similarity	NOUN
gs-4321	615	5	in	in	ADP
gs-4321	615	6	adaptive	adaptive	ADJ
gs-4321	615	7	structure	structure	NOUN
gs-4321	615	8	the	the	DET
gs-4321	615	9	consistent	consistent	ADJ
gs-4321	615	10	detection	detection	NOUN
gs-4321	615	11	of	of	ADP
gs-4321	615	12	analogous	analogous	ADJ
gs-4321	615	13	states	state	NOUN
gs-4321	615	14	across	across	ADP
gs-4321	615	15	different	different	ADJ
gs-4321	615	16	cancer	cancer	NOUN
gs-4321	615	17	types	type	NOUN
gs-4321	615	18	suggests	suggest	VERB
gs-4321	615	19	that	that	SCONJ
gs-4321	615	20	adaptive	adaptive	ADJ
gs-4321	615	21	structures	structure	NOUN
gs-4321	615	22	may	may	AUX
gs-4321	615	23	be	be	AUX
gs-4321	615	24	universal	universal	ADJ
gs-4321	615	25	across	across	ADP
gs-4321	615	26	solid	solid	ADJ
gs-4321	615	27	tumors	tumor	NOUN
gs-4321	615	28	.	.	PUNCT
gs-4321	616	1	studies	study	NOUN
gs-4321	616	2	in	in	ADP
gs-4321	616	3	diverse	diverse	ADJ
gs-4321	616	4	malignancies	malignancy	NOUN
gs-4321	616	5	—	—	PUNCT
gs-4321	616	6	including	include	VERB
gs-4321	616	7	colorectal	colorectal	ADJ
gs-4321	616	8	,	,	PUNCT
gs-4321	616	9	pancreatic	pancreatic	ADJ
gs-4321	616	10	,	,	PUNCT
gs-4321	616	11	breast	breast	NOUN
gs-4321	616	12	,	,	PUNCT
gs-4321	616	13	lung	lung	NOUN
gs-4321	616	14	,	,	PUNCT
gs-4321	616	15	and	and	CCONJ
gs-4321	616	16	brain	brain	NOUN
gs-4321	616	17	tumors	tumor	NOUN
gs-4321	616	18	—	—	PUNCT
gs-4321	616	19	have	have	AUX
gs-4321	616	20	reported	report	VERB
gs-4321	616	21	similar	similar	ADJ
gs-4321	616	22	gradients	gradient	NOUN
gs-4321	616	23	of	of	ADP
gs-4321	616	24	differentiation	differentiation	NOUN
gs-4321	616	25	,	,	PUNCT
gs-4321	616	26	intermediate	intermediate	ADJ
gs-4321	616	27	states	state	NOUN
gs-4321	616	28	,	,	PUNCT
gs-4321	616	29	and	and	CCONJ
gs-4321	616	30	plastic	plastic	NOUN
gs-4321	616	31	stem	stem	NOUN
gs-4321	616	32	-	-	PUNCT
gs-4321	616	33	like	like	ADJ
gs-4321	616	34	phenotypes	phenotype	NOUN
gs-4321	616	35	(	(	PUNCT
gs-4321	616	36	kim	kim	PROPN
gs-4321	616	37	et	et	PROPN
gs-4321	616	38	al	al	PROPN
gs-4321	616	39	.	.	PROPN
gs-4321	616	40	,	,	PUNCT
gs-4321	616	41	2020	2020	NUM
gs-4321	616	42	;	;	PUNCT
gs-4321	616	43	neftel	neftel	NOUN
gs-4321	616	44	et	et	PROPN
gs-4321	616	45	al	al	PROPN
gs-4321	616	46	.	.	PROPN
gs-4321	616	47	,	,	PUNCT
gs-4321	616	48	2019	2019	NUM
gs-4321	616	49	)	)	PUNCT
gs-4321	616	50	.	.	PUNCT
gs-4321	617	1	this	this	DET
gs-4321	617	2	cross	cross	ADJ
gs-4321	617	3	-	-	ADJ
gs-4321	617	4	tumor	tumor	ADJ
gs-4321	617	5	consistency	consistency	NOUN
gs-4321	617	6	indicates	indicate	VERB
gs-4321	617	7	that	that	SCONJ
gs-4321	617	8	adaptive	adaptive	ADJ
gs-4321	617	9	strategies	strategy	NOUN
gs-4321	617	10	may	may	AUX
gs-4321	617	11	be	be	AUX
gs-4321	617	12	evolutionarily	evolutionarily	ADV
gs-4321	617	13	conserved	conserve	VERB
gs-4321	617	14	,	,	PUNCT
gs-4321	617	15	and	and	CCONJ
gs-4321	617	16	that	that	SCONJ
gs-4321	617	17	therapeutic	therapeutic	ADJ
gs-4321	617	18	approaches	approach	NOUN
gs-4321	617	19	targeting	target	VERB
gs-4321	617	20	plasticity	plasticity	NOUN
gs-4321	617	21	may	may	AUX
gs-4321	617	22	have	have	VERB
gs-4321	617	23	broad	broad	ADJ
gs-4321	617	24	applicability	applicability	NOUN
gs-4321	617	25	.	.	PUNCT
gs-4321	618	1	implications	implication	NOUN
gs-4321	618	2	for	for	ADP
gs-4321	618	3	metastatic	metastatic	ADJ
gs-4321	618	4	dissemination	dissemination	NOUN
gs-4321	618	5	plasticity	plasticity	NOUN
gs-4321	618	6	has	have	AUX
gs-4321	618	7	been	be	AUX
gs-4321	618	8	strongly	strongly	ADV
gs-4321	618	9	linked	link	VERB
gs-4321	618	10	to	to	ADP
gs-4321	618	11	metastatic	metastatic	ADJ
gs-4321	618	12	potential	potential	NOUN
gs-4321	618	13	.	.	PUNCT
gs-4321	619	1	hybrid	hybrid	ADJ
gs-4321	619	2	epithelial	epithelial	ADJ
gs-4321	619	3	–	–	PUNCT
gs-4321	619	4	mesenchymal	mesenchymal	ADJ
gs-4321	619	5	states	state	NOUN
gs-4321	619	6	,	,	PUNCT
gs-4321	619	7	which	which	PRON
gs-4321	619	8	share	share	VERB
gs-4321	619	9	features	feature	VERB
gs-4321	619	10	with	with	ADP
gs-4321	619	11	the	the	DET
gs-4321	619	12	intermediate	intermediate	ADJ
gs-4321	619	13	populations	population	NOUN
gs-4321	619	14	described	describe	VERB
gs-4321	619	15	in	in	ADP
gs-4321	619	16	our	our	PRON
gs-4321	619	17	study	study	NOUN
gs-4321	619	18	,	,	PUNCT
gs-4321	619	19	are	be	AUX
gs-4321	619	20	associated	associate	VERB
gs-4321	619	21	with	with	ADP
gs-4321	619	22	increased	increase	VERB
gs-4321	619	23	dissemination	dissemination	NOUN
gs-4321	619	24	and	and	CCONJ
gs-4321	619	25	colonization	colonization	NOUN
gs-4321	619	26	efficiency	efficiency	NOUN
gs-4321	619	27	(	(	PUNCT
gs-4321	619	28	dongre	dongre	NOUN
gs-4321	619	29	and	and	CCONJ
gs-4321	619	30	weinberg	weinberg	PROPN
gs-4321	619	31	,	,	PUNCT
gs-4321	619	32	2019	2019	NUM
gs-4321	619	33	;	;	PUNCT
gs-4321	619	34	pastushenko	pastushenko	PROPN
gs-4321	619	35	et	et	PROPN
gs-4321	619	36	al	al	PROPN
gs-4321	619	37	.	.	PROPN
gs-4321	619	38	,	,	PUNCT
gs-4321	619	39	2018	2018	NUM
gs-4321	619	40	)	)	PUNCT
gs-4321	619	41	.	.	PUNCT
gs-4321	620	1	our	our	PRON
gs-4321	620	2	identification	identification	NOUN
gs-4321	620	3	of	of	ADP
gs-4321	620	4	intermediate	intermediate	ADJ
gs-4321	620	5	states	state	NOUN
gs-4321	620	6	enriched	enrich	VERB
gs-4321	620	7	for	for	ADP
gs-4321	620	8	regulatory	regulatory	ADJ
gs-4321	620	9	programs	program	NOUN
gs-4321	620	10	and	and	CCONJ
gs-4321	620	11	signaling	signal	VERB
gs-4321	620	12	responses	response	NOUN
gs-4321	620	13	suggests	suggest	VERB
gs-4321	620	14	that	that	SCONJ
gs-4321	620	15	these	these	DET
gs-4321	620	16	populations	population	NOUN
gs-4321	620	17	may	may	AUX
gs-4321	620	18	represent	represent	VERB
gs-4321	620	19	metastasis	metastasis	NOUN
gs-4321	620	20	-	-	PUNCT
gs-4321	620	21	initiating	initiate	VERB
gs-4321	620	22	cells	cell	NOUN
gs-4321	620	23	.	.	PUNCT
gs-4321	621	1	further	far	ADV
gs-4321	621	2	experimentally	experimentally	ADV
gs-4321	621	3	validated	validate	VERB
gs-4321	621	4	studies	study	NOUN
gs-4321	621	5	are	be	AUX
gs-4321	621	6	needed	need	VERB
gs-4321	621	7	to	to	PART
gs-4321	621	8	confirm	confirm	VERB
gs-4321	621	9	this	this	DET
gs-4321	621	10	hypothesis	hypothesis	NOUN
gs-4321	621	11	.	.	PUNCT
gs-4321	622	1	therapeutic	therapeutic	ADJ
gs-4321	622	2	targeting	targeting	NOUN
gs-4321	622	3	of	of	ADP
gs-4321	622	4	lineage	lineage	NOUN
gs-4321	622	5	plasticity	plasticity	NOUN
gs-4321	622	6	given	give	VERB
gs-4321	622	7	the	the	DET
gs-4321	622	8	central	central	ADJ
gs-4321	622	9	involvement	involvement	NOUN
gs-4321	622	10	of	of	ADP
gs-4321	622	11	lineage	lineage	NOUN
gs-4321	622	12	plasticity	plasticity	NOUN
gs-4321	622	13	in	in	ADP
gs-4321	622	14	resistance	resistance	NOUN
gs-4321	622	15	,	,	PUNCT
gs-4321	622	16	several	several	ADJ
gs-4321	622	17	therapeutic	therapeutic	ADJ
gs-4321	622	18	strategies	strategy	NOUN
gs-4321	622	19	have	have	AUX
gs-4321	622	20	been	be	AUX
gs-4321	622	21	developed	develop	VERB
gs-4321	622	22	to	to	PART
gs-4321	622	23	limit	limit	VERB
gs-4321	622	24	or	or	CCONJ
gs-4321	622	25	reverse	reverse	VERB
gs-4321	622	26	adaptive	adaptive	ADJ
gs-4321	622	27	transitions	transition	NOUN
gs-4321	622	28	.	.	PUNCT
gs-4321	623	1	epigenetic	epigenetic	ADJ
gs-4321	623	2	inhibitors	inhibitor	NOUN
gs-4321	623	3	such	such	ADJ
gs-4321	623	4	as	as	ADP
gs-4321	623	5	bet	bet	NOUN
gs-4321	623	6	,	,	PUNCT
gs-4321	623	7	hdac	hdac	PROPN
gs-4321	623	8	,	,	PUNCT
gs-4321	623	9	and	and	CCONJ
gs-4321	623	10	ezh2	ezh2	ADJ
gs-4321	623	11	inhibitors	inhibitor	NOUN
gs-4321	623	12	have	have	AUX
gs-4321	623	13	demonstrated	demonstrate	VERB
gs-4321	623	14	the	the	DET
gs-4321	623	15	ability	ability	NOUN
gs-4321	623	16	to	to	PART
gs-4321	623	17	reduce	reduce	VERB
gs-4321	623	18	transcriptional	transcriptional	ADJ
gs-4321	623	19	flexibility	flexibility	NOUN
gs-4321	623	20	or	or	CCONJ
gs-4321	623	21	restore	restore	VERB
gs-4321	623	22	lineage	lineage	NOUN
gs-4321	623	23	programs	program	NOUN
gs-4321	623	24	(	(	PUNCT
gs-4321	623	25	liau	liau	NOUN
gs-4321	623	26	et	et	PROPN
gs-4321	623	27	al	al	PROPN
gs-4321	623	28	.	.	PROPN
gs-4321	623	29	,	,	PUNCT
gs-4321	623	30	2017	2017	NUM
gs-4321	623	31	;	;	PUNCT
gs-4321	623	32	su	su	PROPN
gs-4321	623	33	et	et	PROPN
gs-4321	623	34	al	al	PROPN
gs-4321	623	35	.	.	PROPN
gs-4321	623	36	,	,	PUNCT
gs-4321	623	37	2020	2020	NUM
gs-4321	623	38	)	)	PUNCT
gs-4321	623	39	.	.	PUNCT
gs-4321	624	1	our	our	PRON
gs-4321	624	2	data	datum	NOUN
gs-4321	624	3	support	support	VERB
gs-4321	624	4	the	the	DET
gs-4321	624	5	rationale	rationale	NOUN
gs-4321	624	6	for	for	ADP
gs-4321	624	7	using	use	VERB
gs-4321	624	8	such	such	ADJ
gs-4321	624	9	agents	agent	NOUN
gs-4321	624	10	,	,	PUNCT
gs-4321	624	11	particularly	particularly	ADV
gs-4321	624	12	in	in	ADP
gs-4321	624	13	cases	case	NOUN
gs-4321	624	14	where	where	SCONJ
gs-4321	624	15	intermediate	intermediate	ADJ
gs-4321	624	16	georgian	georgian	NOUN
gs-4321	624	17	scientists/	scientists/	NUM
gs-4321	624	18	.	.	PUNCT
gs-4321	625	1	7	7	NUM
gs-4321	625	2	n	n	DET
gs-4321	625	3	4	4	NUM
gs-4321	625	4	,	,	PUNCT
gs-4321	625	5	2025	2025	NUM
gs-4321	625	6	372	372	NUM
gs-4321	625	7	and	and	CCONJ
gs-4321	625	8	stem	stem	NOUN
gs-4321	625	9	-	-	PUNCT
gs-4321	625	10	like	like	ADJ
gs-4321	625	11	population	population	NOUN
gs-4321	625	12	’s	’s	PART
gs-4321	625	13	exhibit	exhibit	VERB
gs-4321	625	14	high	high	ADJ
gs-4321	625	15	levels	level	NOUN
gs-4321	625	16	of	of	ADP
gs-4321	625	17	chromatin	chromatin	NOUN
gs-4321	625	18	accessibility	accessibility	NOUN
gs-4321	625	19	and	and	CCONJ
gs-4321	625	20	transcription	transcription	NOUN
gs-4321	625	21	factor	factor	NOUN
gs-4321	625	22	activity	activity	NOUN
gs-4321	625	23	.	.	PUNCT
gs-4321	626	1	inhibiting	inhibit	VERB
gs-4321	626	2	key	key	ADJ
gs-4321	626	3	regulators	regulator	NOUN
gs-4321	626	4	such	such	ADJ
gs-4321	626	5	as	as	ADP
gs-4321	626	6	sox2	sox2	NOUN
gs-4321	626	7	or	or	CCONJ
gs-4321	626	8	jun	jun	PROPN
gs-4321	626	9	may	may	AUX
gs-4321	626	10	disrupt	disrupt	VERB
gs-4321	626	11	plasticityassociated	plasticityassociated	ADJ
gs-4321	626	12	circuits	circuit	NOUN
gs-4321	626	13	.	.	PUNCT
gs-4321	627	1	targeting	target	VERB
gs-4321	627	2	microenvironmental	microenvironmental	ADJ
gs-4321	627	3	drivers	driver	NOUN
gs-4321	627	4	intervening	intervene	VERB
gs-4321	627	5	in	in	ADP
gs-4321	627	6	the	the	DET
gs-4321	627	7	microenvironmental	microenvironmental	ADJ
gs-4321	627	8	mechanisms	mechanism	NOUN
gs-4321	627	9	that	that	PRON
gs-4321	627	10	promote	promote	VERB
gs-4321	627	11	plasticity	plasticity	NOUN
gs-4321	627	12	is	be	AUX
gs-4321	627	13	an	an	DET
gs-4321	627	14	alternative	alternative	ADJ
gs-4321	627	15	strategy	strategy	NOUN
gs-4321	627	16	.	.	PUNCT
gs-4321	628	1	blocking	block	VERB
gs-4321	628	2	il-6	il-6	NOUN
gs-4321	628	3	/	/	SYM
gs-4321	628	4	stat3	stat3	NOUN
gs-4321	628	5	signaling	signal	VERB
gs-4321	628	6	has	have	AUX
gs-4321	628	7	been	be	AUX
gs-4321	628	8	shown	show	VERB
gs-4321	628	9	to	to	PART
gs-4321	628	10	reduce	reduce	VERB
gs-4321	628	11	stemness	stemness	ADV
gs-4321	628	12	and	and	CCONJ
gs-4321	628	13	restore	restore	VERB
gs-4321	628	14	drug	drug	NOUN
gs-4321	628	15	sensitivity	sensitivity	NOUN
gs-4321	628	16	,	,	PUNCT
gs-4321	628	17	while	while	SCONJ
gs-4321	628	18	tgf	tgf	PROPN
gs-4321	628	19	inhibitors	inhibitor	NOUN
gs-4321	628	20	are	be	AUX
gs-4321	628	21	being	be	AUX
gs-4321	628	22	investigated	investigate	VERB
gs-4321	628	23	for	for	ADP
gs-4321	628	24	their	their	PRON
gs-4321	628	25	roles	role	NOUN
gs-4321	628	26	in	in	ADP
gs-4321	628	27	suppressing	suppress	VERB
gs-4321	628	28	emt	emt	NOUN
gs-4321	628	29	-	-	PUNCT
gs-4321	628	30	associated	associate	VERB
gs-4321	628	31	plasticity	plasticity	NOUN
gs-4321	628	32	(	(	PUNCT
gs-4321	628	33	nguyen	nguyen	NOUN
gs-4321	628	34	et	et	PROPN
gs-4321	628	35	al	al	PROPN
gs-4321	628	36	.	.	PROPN
gs-4321	628	37	,	,	PUNCT
gs-4321	628	38	2020	2020	NUM
gs-4321	628	39	)	)	PUNCT
gs-4321	628	40	.	.	PUNCT
gs-4321	629	1	our	our	PRON
gs-4321	629	2	signaling	signal	VERB
gs-4321	629	3	analyses	analysis	NOUN
gs-4321	629	4	show	show	VERB
gs-4321	629	5	increased	increase	VERB
gs-4321	629	6	activity	activity	NOUN
gs-4321	629	7	in	in	ADP
gs-4321	629	8	these	these	DET
gs-4321	629	9	pathways	pathway	NOUN
gs-4321	629	10	along	along	ADP
gs-4321	629	11	adaptive	adaptive	ADJ
gs-4321	629	12	trajectories	trajectory	NOUN
gs-4321	629	13	,	,	PUNCT
gs-4321	629	14	providing	provide	VERB
gs-4321	629	15	a	a	DET
gs-4321	629	16	strong	strong	ADJ
gs-4321	629	17	rationale	rationale	NOUN
gs-4321	629	18	for	for	ADP
gs-4321	629	19	therapeutic	therapeutic	ADJ
gs-4321	629	20	targeting	targeting	NOUN
gs-4321	629	21	.	.	PUNCT
gs-4321	629	22	combination	combination	NOUN
gs-4321	629	23	therapies	therapy	NOUN
gs-4321	629	24	that	that	PRON
gs-4321	629	25	target	target	VERB
gs-4321	629	26	both	both	CCONJ
gs-4321	629	27	intrinsic	intrinsic	ADJ
gs-4321	629	28	and	and	CCONJ
gs-4321	629	29	extrinsic	extrinsic	ADJ
gs-4321	629	30	drivers	driver	NOUN
gs-4321	629	31	may	may	AUX
gs-4321	629	32	offer	offer	VERB
gs-4321	629	33	synergistic	synergistic	ADJ
gs-4321	629	34	benefits	benefit	NOUN
gs-4321	629	35	.	.	PUNCT
gs-4321	630	1	exploiting	exploit	VERB
gs-4321	630	2	vulnerabilities	vulnerability	NOUN
gs-4321	630	3	of	of	ADP
gs-4321	630	4	plastic	plastic	ADJ
gs-4321	630	5	populations	population	NOUN
gs-4321	630	6	plastic	plastic	NOUN
gs-4321	630	7	populations	population	NOUN
gs-4321	630	8	often	often	ADV
gs-4321	630	9	display	display	VERB
gs-4321	630	10	unique	unique	ADJ
gs-4321	630	11	metabolic	metabolic	NOUN
gs-4321	630	12	and	and	CCONJ
gs-4321	630	13	stress	stress	NOUN
gs-4321	630	14	-	-	PUNCT
gs-4321	630	15	adaptation	adaptation	NOUN
gs-4321	630	16	dependencies	dependency	NOUN
gs-4321	630	17	.	.	PUNCT
gs-4321	631	1	for	for	ADP
gs-4321	631	2	example	example	NOUN
gs-4321	631	3	,	,	PUNCT
gs-4321	631	4	persister	persister	ADJ
gs-4321	631	5	cells	cell	NOUN
gs-4321	631	6	rely	rely	VERB
gs-4321	631	7	on	on	ADP
gs-4321	631	8	lipid	lipid	ADJ
gs-4321	631	9	metabolism	metabolism	NOUN
gs-4321	631	10	and	and	CCONJ
gs-4321	631	11	oxidative	oxidative	ADJ
gs-4321	631	12	stress	stress	NOUN
gs-4321	631	13	defenses	defense	NOUN
gs-4321	631	14	for	for	ADP
gs-4321	631	15	survival	survival	NOUN
gs-4321	631	16	during	during	ADP
gs-4321	631	17	therapy	therapy	NOUN
gs-4321	631	18	exposure	exposure	NOUN
gs-4321	631	19	(	(	PUNCT
gs-4321	631	20	hangauer	hangauer	NOUN
gs-4321	631	21	et	et	PROPN
gs-4321	631	22	al	al	PROPN
gs-4321	631	23	.	.	PROPN
gs-4321	631	24	,	,	PUNCT
gs-4321	631	25	2017	2017	NUM
gs-4321	631	26	)	)	PUNCT
gs-4321	631	27	.	.	PUNCT
gs-4321	632	1	inhibiting	inhibit	VERB
gs-4321	632	2	these	these	DET
gs-4321	632	3	pathways	pathway	NOUN
gs-4321	632	4	may	may	AUX
gs-4321	632	5	selectively	selectively	ADV
gs-4321	632	6	eliminate	eliminate	VERB
gs-4321	632	7	adaptive	adaptive	ADJ
gs-4321	632	8	cells	cell	NOUN
gs-4321	632	9	.	.	PUNCT
gs-4321	633	1	our	our	PRON
gs-4321	633	2	findings	finding	NOUN
gs-4321	633	3	suggest	suggest	VERB
gs-4321	633	4	that	that	SCONJ
gs-4321	633	5	similar	similar	ADJ
gs-4321	633	6	strategies	strategy	NOUN
gs-4321	633	7	could	could	AUX
gs-4321	633	8	be	be	AUX
gs-4321	633	9	effective	effective	ADJ
gs-4321	633	10	against	against	ADP
gs-4321	633	11	intermediate	intermediate	ADJ
gs-4321	633	12	and	and	CCONJ
gs-4321	633	13	stem	stem	NOUN
gs-4321	633	14	-	-	PUNCT
gs-4321	633	15	like	like	ADJ
gs-4321	633	16	populations	population	NOUN
gs-4321	633	17	with	with	ADP
gs-4321	633	18	heightened	heighten	VERB
gs-4321	633	19	metabolic	metabolic	NOUN
gs-4321	633	20	flexibility	flexibility	NOUN
gs-4321	633	21	.	.	PUNCT
gs-4321	634	1	preventing	prevent	VERB
gs-4321	634	2	the	the	DET
gs-4321	634	3	emergence	emergence	NOUN
gs-4321	634	4	of	of	ADP
gs-4321	634	5	plastic	plastic	ADJ
gs-4321	634	6	cells	cell	NOUN
gs-4321	634	7	another	another	DET
gs-4321	634	8	therapeutic	therapeutic	ADJ
gs-4321	634	9	approach	approach	NOUN
gs-4321	634	10	involves	involve	VERB
gs-4321	634	11	preventing	prevent	VERB
gs-4321	634	12	transitions	transition	NOUN
gs-4321	634	13	into	into	ADP
gs-4321	634	14	plastic	plastic	ADJ
gs-4321	634	15	states	state	NOUN
gs-4321	634	16	before	before	SCONJ
gs-4321	634	17	they	they	PRON
gs-4321	634	18	occur	occur	VERB
gs-4321	634	19	.	.	PUNCT
gs-4321	635	1	this	this	DET
gs-4321	635	2	strategy	strategy	NOUN
gs-4321	635	3	requires	require	VERB
gs-4321	635	4	identification	identification	NOUN
gs-4321	635	5	of	of	ADP
gs-4321	635	6	early	early	ADJ
gs-4321	635	7	markers	marker	NOUN
gs-4321	635	8	that	that	PRON
gs-4321	635	9	predict	predict	VERB
gs-4321	635	10	state	state	NOUN
gs-4321	635	11	transitions	transition	NOUN
gs-4321	635	12	.	.	PUNCT
gs-4321	636	1	our	our	PRON
gs-4321	636	2	analyses	analysis	NOUN
gs-4321	636	3	indicate	indicate	VERB
gs-4321	636	4	that	that	SCONJ
gs-4321	636	5	early	early	ADJ
gs-4321	636	6	upregulation	upregulation	NOUN
gs-4321	636	7	of	of	ADP
gs-4321	636	8	stress	stress	NOUN
gs-4321	636	9	-	-	PUNCT
gs-4321	636	10	responsive	responsive	ADJ
gs-4321	636	11	and	and	CCONJ
gs-4321	636	12	lineage	lineage	NOUN
gs-4321	636	13	-	-	PUNCT
gs-4321	636	14	remodeling	remodeling	NOUN
gs-4321	636	15	transcription	transcription	NOUN
gs-4321	636	16	factors	factor	NOUN
gs-4321	636	17	may	may	AUX
gs-4321	636	18	serve	serve	VERB
gs-4321	636	19	as	as	ADP
gs-4321	636	20	predictive	predictive	ADJ
gs-4321	636	21	markers	marker	NOUN
gs-4321	636	22	of	of	ADP
gs-4321	636	23	plasticity	plasticity	NOUN
gs-4321	636	24	.	.	PUNCT
gs-4321	637	1	combination	combination	NOUN
gs-4321	637	2	therapies	therapy	NOUN
gs-4321	637	3	that	that	PRON
gs-4321	637	4	block	block	VERB
gs-4321	637	5	these	these	DET
gs-4321	637	6	early	early	ADJ
gs-4321	637	7	regulators	regulator	NOUN
gs-4321	637	8	may	may	AUX
gs-4321	637	9	prevent	prevent	VERB
gs-4321	637	10	the	the	DET
gs-4321	637	11	development	development	NOUN
gs-4321	637	12	of	of	ADP
gs-4321	637	13	resistant	resistant	ADJ
gs-4321	637	14	states	state	NOUN
gs-4321	637	15	.	.	PUNCT
gs-4321	638	1	challenges	challenge	NOUN
gs-4321	638	2	in	in	ADP
gs-4321	638	3	targeting	target	VERB
gs-4321	638	4	plasticity	plasticity	NOUN
gs-4321	638	5	targeting	target	VERB
gs-4321	638	6	plasticity	plasticity	NOUN
gs-4321	638	7	poses	pose	VERB
gs-4321	638	8	several	several	ADJ
gs-4321	638	9	challenges	challenge	NOUN
gs-4321	638	10	.	.	PUNCT
gs-4321	639	1	first	first	ADV
gs-4321	639	2	,	,	PUNCT
gs-4321	639	3	plastic	plastic	ADJ
gs-4321	639	4	populations	population	NOUN
gs-4321	639	5	are	be	AUX
gs-4321	639	6	dynamic	dynamic	ADJ
gs-4321	639	7	and	and	CCONJ
gs-4321	639	8	may	may	AUX
gs-4321	639	9	rapidly	rapidly	ADV
gs-4321	639	10	regenerate	regenerate	VERB
gs-4321	639	11	even	even	ADV
gs-4321	639	12	after	after	ADP
gs-4321	639	13	targeted	target	VERB
gs-4321	639	14	elimination	elimination	NOUN
gs-4321	639	15	.	.	PUNCT
gs-4321	640	1	second	second	ADJ
gs-4321	640	2	,	,	PUNCT
gs-4321	640	3	plasticity	plasticity	NOUN
gs-4321	640	4	may	may	AUX
gs-4321	640	5	be	be	AUX
gs-4321	640	6	driven	drive	VERB
gs-4321	640	7	by	by	ADP
gs-4321	640	8	multiple	multiple	ADJ
gs-4321	640	9	redundant	redundant	ADJ
gs-4321	640	10	pathways	pathway	NOUN
gs-4321	640	11	,	,	PUNCT
gs-4321	640	12	complicating	complicate	VERB
gs-4321	640	13	single	single	ADJ
gs-4321	640	14	-	-	PUNCT
gs-4321	640	15	agent	agent	NOUN
gs-4321	640	16	approaches	approach	NOUN
gs-4321	640	17	.	.	PUNCT
gs-4321	641	1	finally	finally	ADV
gs-4321	641	2	,	,	PUNCT
gs-4321	641	3	suppressing	suppress	VERB
gs-4321	641	4	plastic	plastic	ADJ
gs-4321	641	5	states	state	NOUN
gs-4321	641	6	may	may	AUX
gs-4321	641	7	inadvertently	inadvertently	ADV
gs-4321	641	8	promote	promote	VERB
gs-4321	641	9	selection	selection	NOUN
gs-4321	641	10	for	for	ADP
gs-4321	641	11	genetically	genetically	ADV
gs-4321	641	12	resistant	resistant	ADJ
gs-4321	641	13	clones	clone	NOUN
gs-4321	641	14	.	.	PUNCT
gs-4321	642	1	a	a	DET
gs-4321	642	2	deeper	deep	ADJ
gs-4321	642	3	understanding	understanding	NOUN
gs-4321	642	4	of	of	ADP
gs-4321	642	5	the	the	DET
gs-4321	642	6	interplay	interplay	NOUN
gs-4321	642	7	between	between	ADP
gs-4321	642	8	plasticity	plasticity	NOUN
gs-4321	642	9	and	and	CCONJ
gs-4321	642	10	clonal	clonal	ADJ
gs-4321	642	11	evolution	evolution	NOUN
gs-4321	642	12	is	be	AUX
gs-4321	642	13	necessary	necessary	ADJ
gs-4321	642	14	to	to	PART
gs-4321	642	15	design	design	VERB
gs-4321	642	16	durable	durable	ADJ
gs-4321	642	17	treatments	treatment	NOUN
gs-4321	642	18	.	.	PUNCT
gs-4321	643	1	integration	integration	NOUN
gs-4321	643	2	of	of	ADP
gs-4321	643	3	single	single	ADJ
gs-4321	643	4	-	-	PUNCT
gs-4321	643	5	cell	cell	NOUN
gs-4321	643	6	multiomics	multiomics	NOUN
gs-4321	643	7	for	for	ADP
gs-4321	643	8	plasticity	plasticity	NOUN
gs-4321	643	9	research	research	NOUN
gs-4321	643	10	single	single	ADJ
gs-4321	643	11	-	-	PUNCT
gs-4321	643	12	cell	cell	NOUN
gs-4321	643	13	multiomic	multiomic	ADJ
gs-4321	643	14	technologies	technology	NOUN
gs-4321	643	15	combining	combine	VERB
gs-4321	643	16	transcriptomic	transcriptomic	ADJ
gs-4321	643	17	,	,	PUNCT
gs-4321	643	18	epigenomic	epigenomic	ADJ
gs-4321	643	19	,	,	PUNCT
gs-4321	643	20	and	and	CCONJ
gs-4321	643	21	proteomic	proteomic	ADJ
gs-4321	643	22	data	datum	NOUN
gs-4321	643	23	offer	offer	VERB
gs-4321	643	24	powerful	powerful	ADJ
gs-4321	643	25	tools	tool	NOUN
gs-4321	643	26	to	to	PART
gs-4321	643	27	dissect	dissect	VERB
gs-4321	643	28	plasticity	plasticity	NOUN
gs-4321	643	29	at	at	ADP
gs-4321	643	30	unprecedented	unprecedented	ADJ
gs-4321	643	31	resolution	resolution	NOUN
gs-4321	643	32	.	.	PUNCT
gs-4321	644	1	techniques	technique	NOUN
gs-4321	644	2	such	such	ADJ
gs-4321	644	3	as	as	ADP
gs-4321	644	4	share	share	NOUN
gs-4321	644	5	-	-	PUNCT
gs-4321	644	6	seq	seq	NOUN
gs-4321	644	7	,	,	PUNCT
gs-4321	644	8	cite	cite	ADJ
gs-4321	644	9	-	-	PUNCT
gs-4321	644	10	seq	seq	NOUN
gs-4321	644	11	,	,	PUNCT
gs-4321	644	12	and	and	CCONJ
gs-4321	644	13	10x	10x	PROPN
gs-4321	644	14	multiome	multiome	PROPN
gs-4321	644	15	allow	allow	VERB
gs-4321	644	16	direct	direct	ADJ
gs-4321	644	17	measurement	measurement	NOUN
gs-4321	644	18	of	of	ADP
gs-4321	644	19	chromatin	chromatin	NOUN
gs-4321	644	20	accessibility	accessibility	NOUN
gs-4321	644	21	and	and	CCONJ
gs-4321	644	22	protein	protein	NOUN
gs-4321	644	23	expression	expression	NOUN
gs-4321	644	24	alongside	alongside	ADP
gs-4321	644	25	transcription	transcription	NOUN
gs-4321	644	26	(	(	PUNCT
gs-4321	644	27	ma	ma	PROPN
gs-4321	644	28	et	et	PROPN
gs-4321	644	29	al	al	PROPN
gs-4321	644	30	.	.	PROPN
gs-4321	644	31	,	,	PUNCT
gs-4321	644	32	2020	2020	NUM
gs-4321	644	33	)	)	PUNCT
gs-4321	644	34	.	.	PUNCT
gs-4321	645	1	integrating	integrate	VERB
gs-4321	645	2	these	these	DET
gs-4321	645	3	modalities	modality	NOUN
gs-4321	645	4	may	may	AUX
gs-4321	645	5	reveal	reveal	VERB
gs-4321	645	6	regulatory	regulatory	ADJ
gs-4321	645	7	events	event	NOUN
gs-4321	645	8	that	that	PRON
gs-4321	645	9	precede	precede	VERB
gs-4321	645	10	transcriptional	transcriptional	ADJ
gs-4321	645	11	changes	change	NOUN
gs-4321	645	12	.	.	PUNCT
gs-4321	646	1	our	our	PRON
gs-4321	646	2	georgian	georgian	NOUN
gs-4321	646	3	scientists/	scientists/	NUM
gs-4321	646	4	.	.	PUNCT
gs-4321	647	1	7	7	NUM
gs-4321	647	2	n	n	DET
gs-4321	647	3	4	4	NUM
gs-4321	647	4	,	,	PUNCT
gs-4321	647	5	2025	2025	NUM
gs-4321	647	6	373	373	NUM
gs-4321	647	7	findings	finding	NOUN
gs-4321	647	8	provide	provide	VERB
gs-4321	647	9	a	a	DET
gs-4321	647	10	framework	framework	NOUN
gs-4321	647	11	for	for	ADP
gs-4321	647	12	such	such	ADJ
gs-4321	647	13	future	future	ADJ
gs-4321	647	14	multiomic	multiomic	ADJ
gs-4321	647	15	studies	study	NOUN
gs-4321	647	16	by	by	ADP
gs-4321	647	17	identifying	identify	VERB
gs-4321	647	18	key	key	ADJ
gs-4321	647	19	transcriptional	transcriptional	NOUN
gs-4321	647	20	and	and	CCONJ
gs-4321	647	21	regulatory	regulatory	ADJ
gs-4321	647	22	axes	axis	NOUN
gs-4321	647	23	driving	drive	VERB
gs-4321	647	24	state	state	NOUN
gs-4321	647	25	transitions	transition	NOUN
gs-4321	647	26	.	.	PUNCT
gs-4321	648	1	spatial	spatial	ADJ
gs-4321	648	2	profiling	profiling	NOUN
gs-4321	648	3	to	to	PART
gs-4321	648	4	understand	understand	VERB
gs-4321	648	5	niche	niche	NOUN
gs-4321	648	6	-	-	PUNCT
gs-4321	648	7	dependent	dependent	ADJ
gs-4321	648	8	plasticity	plasticity	NOUN
gs-4321	648	9	spatial	spatial	ADJ
gs-4321	648	10	transcriptomics	transcriptomic	NOUN
gs-4321	648	11	represents	represent	VERB
gs-4321	648	12	a	a	DET
gs-4321	648	13	crucial	crucial	ADJ
gs-4321	648	14	extension	extension	NOUN
gs-4321	648	15	to	to	ADP
gs-4321	648	16	our	our	PRON
gs-4321	648	17	work	work	NOUN
gs-4321	648	18	.	.	PUNCT
gs-4321	649	1	tumors	tumor	NOUN
gs-4321	649	2	consist	consist	VERB
gs-4321	649	3	of	of	ADP
gs-4321	649	4	highly	highly	ADV
gs-4321	649	5	heterogeneous	heterogeneous	ADJ
gs-4321	649	6	microenvironments	microenvironment	NOUN
gs-4321	649	7	,	,	PUNCT
gs-4321	649	8	and	and	CCONJ
gs-4321	649	9	plasticity	plasticity	NOUN
gs-4321	649	10	often	often	ADV
gs-4321	649	11	occurs	occur	VERB
gs-4321	649	12	in	in	ADP
gs-4321	649	13	spatially	spatially	ADV
gs-4321	649	14	restricted	restrict	VERB
gs-4321	649	15	niches	niche	NOUN
gs-4321	649	16	such	such	ADJ
gs-4321	649	17	as	as	ADP
gs-4321	649	18	hypoxic	hypoxic	ADJ
gs-4321	649	19	regions	region	NOUN
gs-4321	649	20	,	,	PUNCT
gs-4321	649	21	invasive	invasive	ADJ
gs-4321	649	22	fronts	front	NOUN
gs-4321	649	23	,	,	PUNCT
gs-4321	649	24	and	and	CCONJ
gs-4321	649	25	immune	immune	NOUN
gs-4321	649	26	-	-	PUNCT
gs-4321	649	27	suppressed	suppress	VERB
gs-4321	649	28	zones	zone	NOUN
gs-4321	649	29	(	(	PUNCT
gs-4321	649	30	jensen	jensen	PROPN
gs-4321	649	31	et	et	PROPN
gs-4321	649	32	al	al	PROPN
gs-4321	649	33	.	.	PROPN
gs-4321	649	34	,	,	PUNCT
gs-4321	649	35	2021	2021	NUM
gs-4321	649	36	)	)	PUNCT
gs-4321	649	37	.	.	PUNCT
gs-4321	650	1	future	future	ADJ
gs-4321	650	2	studies	study	NOUN
gs-4321	650	3	that	that	PRON
gs-4321	650	4	overlay	overlay	VERB
gs-4321	650	5	state	state	NOUN
gs-4321	650	6	identity	identity	NOUN
gs-4321	650	7	with	with	ADP
gs-4321	650	8	spatial	spatial	ADJ
gs-4321	650	9	context	context	NOUN
gs-4321	650	10	will	will	AUX
gs-4321	650	11	provide	provide	VERB
gs-4321	650	12	deeper	deep	ADJ
gs-4321	650	13	insight	insight	NOUN
gs-4321	650	14	into	into	ADP
gs-4321	650	15	how	how	SCONJ
gs-4321	650	16	local	local	ADJ
gs-4321	650	17	cues	cue	NOUN
gs-4321	650	18	shape	shape	NOUN
gs-4321	650	19	phenotype	phenotype	NOUN
gs-4321	650	20	.	.	PUNCT
gs-4321	651	1	integration	integration	NOUN
gs-4321	651	2	with	with	ADP
gs-4321	651	3	imaging	imaging	NOUN
gs-4321	651	4	-	-	PUNCT
gs-4321	651	5	based	base	VERB
gs-4321	651	6	proteomics	proteomic	NOUN
gs-4321	651	7	could	could	AUX
gs-4321	651	8	map	map	VERB
gs-4321	651	9	niche	niche	NOUN
gs-4321	651	10	-	-	PUNCT
gs-4321	651	11	specific	specific	ADJ
gs-4321	651	12	cytokine	cytokine	NOUN
gs-4321	651	13	gradients	gradient	NOUN
gs-4321	651	14	that	that	PRON
gs-4321	651	15	drive	drive	VERB
gs-4321	651	16	plasticity	plasticity	NOUN
gs-4321	651	17	.	.	PUNCT
gs-4321	652	1	temporal	temporal	ADJ
gs-4321	652	2	and	and	CCONJ
gs-4321	652	3	perturbation	perturbation	NOUN
gs-4321	652	4	-	-	PUNCT
gs-4321	652	5	based	base	VERB
gs-4321	652	6	single	single	ADJ
gs-4321	652	7	-	-	PUNCT
gs-4321	652	8	cell	cell	NOUN
gs-4321	652	9	studies	study	NOUN
gs-4321	652	10	longitudinal	longitudinal	ADJ
gs-4321	652	11	single	single	ADJ
gs-4321	652	12	-	-	PUNCT
gs-4321	652	13	cell	cell	NOUN
gs-4321	652	14	profiling	profiling	NOUN
gs-4321	652	15	following	follow	VERB
gs-4321	652	16	therapeutic	therapeutic	ADJ
gs-4321	652	17	or	or	CCONJ
gs-4321	652	18	environmental	environmental	ADJ
gs-4321	652	19	perturbations	perturbation	NOUN
gs-4321	652	20	can	can	AUX
gs-4321	652	21	provide	provide	VERB
gs-4321	652	22	direct	direct	ADJ
gs-4321	652	23	evidence	evidence	NOUN
gs-4321	652	24	of	of	ADP
gs-4321	652	25	state	state	NOUN
gs-4321	652	26	transitions	transition	NOUN
gs-4321	652	27	and	and	CCONJ
gs-4321	652	28	help	help	VERB
gs-4321	652	29	validate	validate	VERB
gs-4321	652	30	the	the	DET
gs-4321	652	31	trajectory	trajectory	NOUN
gs-4321	652	32	models	model	NOUN
gs-4321	652	33	inferred	infer	VERB
gs-4321	652	34	from	from	ADP
gs-4321	652	35	steady	steady	ADJ
gs-4321	652	36	-	-	PUNCT
gs-4321	652	37	state	state	NOUN
gs-4321	652	38	data	datum	NOUN
gs-4321	652	39	.	.	PUNCT
gs-4321	653	1	for	for	ADP
gs-4321	653	2	example	example	NOUN
gs-4321	653	3	,	,	PUNCT
gs-4321	653	4	time	time	NOUN
gs-4321	653	5	-	-	PUNCT
gs-4321	653	6	resolved	resolve	VERB
gs-4321	653	7	analyses	analysis	NOUN
gs-4321	653	8	have	have	AUX
gs-4321	653	9	shown	show	VERB
gs-4321	653	10	that	that	SCONJ
gs-4321	653	11	melanoma	melanoma	NOUN
gs-4321	653	12	cells	cell	NOUN
gs-4321	653	13	transition	transition	VERB
gs-4321	653	14	through	through	ADP
gs-4321	653	15	discrete	discrete	ADJ
gs-4321	653	16	transcriptional	transcriptional	NOUN
gs-4321	653	17	states	state	NOUN
gs-4321	653	18	during	during	ADP
gs-4321	653	19	mapk	mapk	NOUN
gs-4321	653	20	inhibitor	inhibitor	NOUN
gs-4321	653	21	treatment	treatment	NOUN
gs-4321	653	22	(	(	PUNCT
gs-4321	653	23	rambow	rambow	NOUN
gs-4321	653	24	et	et	PROPN
gs-4321	653	25	al	al	PROPN
gs-4321	653	26	.	.	PROPN
gs-4321	653	27	,	,	PUNCT
gs-4321	653	28	2018	2018	NUM
gs-4321	653	29	)	)	PUNCT
gs-4321	653	30	.	.	PUNCT
gs-4321	654	1	similar	similar	ADJ
gs-4321	654	2	perturbation	perturbation	NOUN
gs-4321	654	3	-	-	PUNCT
gs-4321	654	4	based	base	VERB
gs-4321	654	5	strategies	strategy	NOUN
gs-4321	654	6	could	could	AUX
gs-4321	654	7	test	test	VERB
gs-4321	654	8	whether	whether	SCONJ
gs-4321	654	9	the	the	DET
gs-4321	654	10	intermediate	intermediate	ADJ
gs-4321	654	11	populations	population	NOUN
gs-4321	654	12	identified	identify	VERB
gs-4321	654	13	in	in	ADP
gs-4321	654	14	our	our	PRON
gs-4321	654	15	study	study	NOUN
gs-4321	654	16	represent	represent	VERB
gs-4321	654	17	obligatory	obligatory	ADJ
gs-4321	654	18	transitional	transitional	ADJ
gs-4321	654	19	steps	step	NOUN
gs-4321	654	20	or	or	CCONJ
gs-4321	654	21	context	context	NOUN
gs-4321	654	22	-	-	PUNCT
gs-4321	654	23	dependent	dependent	ADJ
gs-4321	654	24	phenotypes	phenotype	NOUN
gs-4321	654	25	.	.	PUNCT
gs-4321	655	1	cross	cross	ADJ
gs-4321	655	2	-	-	ADJ
gs-4321	655	3	species	species	ADJ
gs-4321	655	4	comparisons	comparison	NOUN
gs-4321	655	5	to	to	PART
gs-4321	655	6	identify	identify	VERB
gs-4321	655	7	conserved	conserve	VERB
gs-4321	655	8	plasticity	plasticity	NOUN
gs-4321	655	9	programs	program	NOUN
gs-4321	655	10	comparing	compare	VERB
gs-4321	655	11	human	human	ADJ
gs-4321	655	12	tumor	tumor	NOUN
gs-4321	655	13	plasticity	plasticity	NOUN
gs-4321	655	14	programs	program	NOUN
gs-4321	655	15	with	with	ADP
gs-4321	655	16	those	those	PRON
gs-4321	655	17	in	in	ADP
gs-4321	655	18	mouse	mouse	NOUN
gs-4321	655	19	models	model	NOUN
gs-4321	655	20	may	may	AUX
gs-4321	655	21	help	help	AUX
gs-4321	655	22	identify	identify	VERB
gs-4321	655	23	conserved	conserve	VERB
gs-4321	655	24	regulatory	regulatory	ADJ
gs-4321	655	25	mechanisms	mechanism	NOUN
gs-4321	655	26	.	.	PUNCT
gs-4321	656	1	several	several	ADJ
gs-4321	656	2	studies	study	NOUN
gs-4321	656	3	have	have	AUX
gs-4321	656	4	demonstrated	demonstrate	VERB
gs-4321	656	5	that	that	SCONJ
gs-4321	656	6	lineage	lineage	NOUN
gs-4321	656	7	remodeling	remodeling	NOUN
gs-4321	656	8	and	and	CCONJ
gs-4321	656	9	stress	stress	NOUN
gs-4321	656	10	-	-	PUNCT
gs-4321	656	11	induced	induce	VERB
gs-4321	656	12	transcriptional	transcriptional	ADJ
gs-4321	656	13	programs	program	NOUN
gs-4321	656	14	are	be	AUX
gs-4321	656	15	conserved	conserve	VERB
gs-4321	656	16	across	across	ADP
gs-4321	656	17	species	specie	NOUN
gs-4321	656	18	(	(	PUNCT
gs-4321	656	19	quintanal	quintanal	ADJ
gs-4321	656	20	-	-	PUNCT
gs-4321	656	21	villalonga	villalonga	NOUN
gs-4321	656	22	et	et	NOUN
gs-4321	656	23	al	al	PROPN
gs-4321	656	24	.	.	PROPN
gs-4321	656	25	,	,	PUNCT
gs-4321	656	26	2020	2020	NUM
gs-4321	656	27	)	)	PUNCT
gs-4321	656	28	.	.	PUNCT
gs-4321	657	1	cross	cross	ADJ
gs-4321	657	2	-	-	ADJ
gs-4321	657	3	species	species	ADJ
gs-4321	657	4	single	single	ADJ
gs-4321	657	5	-	-	PUNCT
gs-4321	657	6	cell	cell	NOUN
gs-4321	657	7	integration	integration	NOUN
gs-4321	657	8	could	could	AUX
gs-4321	657	9	help	help	VERB
gs-4321	657	10	validate	validate	VERB
gs-4321	657	11	core	core	ADJ
gs-4321	657	12	regulatory	regulatory	ADJ
gs-4321	657	13	modules	module	NOUN
gs-4321	657	14	and	and	CCONJ
gs-4321	657	15	identify	identify	VERB
gs-4321	657	16	species	specie	NOUN
gs-4321	657	17	-	-	PUNCT
gs-4321	657	18	specific	specific	ADJ
gs-4321	657	19	adaptations	adaptation	NOUN
gs-4321	657	20	.	.	PUNCT
gs-4321	658	1	computational	computational	ADJ
gs-4321	658	2	advances	advance	NOUN
gs-4321	658	3	for	for	ADP
gs-4321	658	4	modeling	model	VERB
gs-4321	658	5	plasticity	plasticity	NOUN
gs-4321	658	6	advances	advance	NOUN
gs-4321	658	7	in	in	ADP
gs-4321	658	8	machine	machine	NOUN
gs-4321	658	9	learning	learning	NOUN
gs-4321	658	10	and	and	CCONJ
gs-4321	658	11	dynamical	dynamical	ADJ
gs-4321	658	12	modeling	modeling	NOUN
gs-4321	658	13	are	be	AUX
gs-4321	658	14	essential	essential	ADJ
gs-4321	658	15	for	for	ADP
gs-4321	658	16	refining	refine	VERB
gs-4321	658	17	our	our	PRON
gs-4321	658	18	understanding	understanding	NOUN
gs-4321	658	19	of	of	ADP
gs-4321	658	20	plasticity	plasticity	NOUN
gs-4321	658	21	.	.	PUNCT
gs-4321	659	1	graph	graph	NOUN
gs-4321	659	2	neural	neural	ADJ
gs-4321	659	3	networks	network	NOUN
gs-4321	659	4	,	,	PUNCT
gs-4321	659	5	probabilistic	probabilistic	ADJ
gs-4321	659	6	trajectory	trajectory	NOUN
gs-4321	659	7	models	model	NOUN
gs-4321	659	8	,	,	PUNCT
gs-4321	659	9	and	and	CCONJ
gs-4321	659	10	deep	deep	ADJ
gs-4321	659	11	generative	generative	ADJ
gs-4321	659	12	models	model	NOUN
gs-4321	659	13	can	can	AUX
gs-4321	659	14	capture	capture	VERB
gs-4321	659	15	complex	complex	ADJ
gs-4321	659	16	relationships	relationship	NOUN
gs-4321	659	17	between	between	ADP
gs-4321	659	18	regulatory	regulatory	ADJ
gs-4321	659	19	layers	layer	NOUN
gs-4321	659	20	,	,	PUNCT
gs-4321	659	21	environmental	environmental	ADJ
gs-4321	659	22	cues	cue	NOUN
gs-4321	659	23	,	,	PUNCT
gs-4321	659	24	and	and	CCONJ
gs-4321	659	25	temporal	temporal	ADJ
gs-4321	659	26	dynamics	dynamic	NOUN
gs-4321	659	27	(	(	PUNCT
gs-4321	659	28	lotfollahi	lotfollahi	X
gs-4321	659	29	et	et	PROPN
gs-4321	659	30	al	al	PROPN
gs-4321	659	31	.	.	PROPN
gs-4321	659	32	,	,	PUNCT
gs-4321	659	33	2019	2019	NUM
gs-4321	659	34	)	)	PUNCT
gs-4321	659	35	.	.	PUNCT
gs-4321	660	1	incorporating	incorporate	VERB
gs-4321	660	2	these	these	DET
gs-4321	660	3	tools	tool	NOUN
gs-4321	660	4	into	into	ADP
gs-4321	660	5	future	future	ADJ
gs-4321	660	6	analyses	analysis	NOUN
gs-4321	660	7	could	could	AUX
gs-4321	660	8	enable	enable	VERB
gs-4321	660	9	prediction	prediction	NOUN
gs-4321	660	10	of	of	ADP
gs-4321	660	11	cell	cell	NOUN
gs-4321	660	12	-	-	PUNCT
gs-4321	660	13	fate	fate	NOUN
gs-4321	660	14	decisions	decision	NOUN
gs-4321	660	15	under	under	ADP
gs-4321	660	16	different	different	ADJ
gs-4321	660	17	therapeutic	therapeutic	ADJ
gs-4321	660	18	contexts	contexts	NOUN
gs-4321	660	19	.	.	PUNCT
gs-4321	661	1	clinical	clinical	ADJ
gs-4321	661	2	implications	implication	NOUN
gs-4321	661	3	of	of	ADP
gs-4321	661	4	identifying	identify	VERB
gs-4321	661	5	adaptive	adaptive	ADJ
gs-4321	661	6	states	state	NOUN
gs-4321	661	7	the	the	DET
gs-4321	661	8	identification	identification	NOUN
gs-4321	661	9	of	of	ADP
gs-4321	661	10	distinct	distinct	ADJ
gs-4321	661	11	adaptive	adaptive	ADJ
gs-4321	661	12	states	state	NOUN
gs-4321	661	13	has	have	VERB
gs-4321	661	14	significant	significant	ADJ
gs-4321	661	15	clinical	clinical	ADJ
gs-4321	661	16	implications	implication	NOUN
gs-4321	661	17	.	.	PUNCT
gs-4321	662	1	for	for	ADP
gs-4321	662	2	example	example	NOUN
gs-4321	662	3	,	,	PUNCT
gs-4321	662	4	detecting	detect	VERB
gs-4321	662	5	intermediate	intermediate	ADJ
gs-4321	662	6	or	or	CCONJ
gs-4321	662	7	stem	stem	NOUN
gs-4321	662	8	-	-	PUNCT
gs-4321	662	9	like	like	ADJ
gs-4321	662	10	populations	population	NOUN
gs-4321	662	11	in	in	ADP
gs-4321	662	12	patient	patient	ADJ
gs-4321	662	13	samples	sample	NOUN
gs-4321	662	14	may	may	AUX
gs-4321	662	15	predict	predict	VERB
gs-4321	662	16	poor	poor	ADJ
gs-4321	662	17	therapeutic	therapeutic	ADJ
gs-4321	662	18	response	response	NOUN
gs-4321	662	19	or	or	CCONJ
gs-4321	662	20	increased	increase	VERB
gs-4321	662	21	risk	risk	NOUN
gs-4321	662	22	of	of	ADP
gs-4321	662	23	recurrence	recurrence	NOUN
gs-4321	662	24	.	.	PUNCT
gs-4321	663	1	single	single	ADJ
gs-4321	663	2	-	-	PUNCT
gs-4321	663	3	cell	cell	NOUN
gs-4321	663	4	diagnostics	diagnostic	NOUN
gs-4321	663	5	,	,	PUNCT
gs-4321	663	6	including	include	VERB
gs-4321	663	7	droplet	droplet	ADJ
gs-4321	663	8	-	-	PUNCT
gs-4321	663	9	based	base	VERB
gs-4321	663	10	transcriptomics	transcriptomic	NOUN
gs-4321	663	11	or	or	CCONJ
gs-4321	663	12	spatial	spatial	ADJ
gs-4321	663	13	profiling	profiling	NOUN
gs-4321	663	14	of	of	ADP
gs-4321	663	15	fine	fine	ADJ
gs-4321	663	16	-	-	PUNCT
gs-4321	663	17	needle	needle	NOUN
gs-4321	663	18	aspirates	aspirate	NOUN
gs-4321	663	19	,	,	PUNCT
gs-4321	663	20	could	could	AUX
gs-4321	663	21	enable	enable	VERB
gs-4321	663	22	early	early	ADJ
gs-4321	663	23	detection	detection	NOUN
gs-4321	663	24	of	of	ADP
gs-4321	663	25	these	these	DET
gs-4321	663	26	populations	population	NOUN
gs-4321	663	27	.	.	PUNCT
gs-4321	664	1	clinical	clinical	ADJ
gs-4321	664	2	correlations	correlation	NOUN
gs-4321	664	3	from	from	ADP
gs-4321	664	4	prior	prior	ADJ
gs-4321	664	5	studies	study	NOUN
gs-4321	664	6	support	support	VERB
gs-4321	664	7	this	this	DET
gs-4321	664	8	georgian	georgian	NOUN
gs-4321	664	9	scientists/	scientists/	NUM
gs-4321	664	10	.	.	PUNCT
gs-4321	665	1	7	7	NUM
gs-4321	665	2	n	n	DET
gs-4321	665	3	4	4	NUM
gs-4321	665	4	,	,	PUNCT
gs-4321	665	5	2025	2025	NUM
gs-4321	665	6	374	374	NUM
gs-4321	665	7	approach	approach	NOUN
gs-4321	665	8	,	,	PUNCT
gs-4321	665	9	showing	show	VERB
gs-4321	665	10	that	that	SCONJ
gs-4321	665	11	stemness	stemness	NOUN
gs-4321	665	12	-	-	PUNCT
gs-4321	665	13	associated	associate	VERB
gs-4321	665	14	signatures	signature	NOUN
gs-4321	665	15	predict	predict	VERB
gs-4321	665	16	relapse	relapse	NOUN
gs-4321	665	17	in	in	ADP
gs-4321	665	18	melanoma	melanoma	NOUN
gs-4321	665	19	,	,	PUNCT
gs-4321	665	20	breast	breast	NOUN
gs-4321	665	21	cancer	cancer	NOUN
gs-4321	665	22	,	,	PUNCT
gs-4321	665	23	and	and	CCONJ
gs-4321	665	24	glioblastoma	glioblastoma	NOUN
gs-4321	665	25	(	(	PUNCT
gs-4321	665	26	kim	kim	PROPN
gs-4321	665	27	et	et	PROPN
gs-4321	665	28	al	al	PROPN
gs-4321	665	29	.	.	PROPN
gs-4321	665	30	,	,	PUNCT
gs-4321	665	31	2020	2020	NUM
gs-4321	665	32	;	;	PUNCT
gs-4321	665	33	suvà	suvà	NOUN
gs-4321	665	34	et	et	PROPN
gs-4321	665	35	al	al	PROPN
gs-4321	665	36	.	.	PROPN
gs-4321	665	37	,	,	PUNCT
gs-4321	665	38	2014	2014	NUM
gs-4321	665	39	)	)	PUNCT
gs-4321	665	40	.	.	PUNCT
gs-4321	666	1	implications	implication	NOUN
gs-4321	666	2	for	for	ADP
gs-4321	666	3	immunotherapy	immunotherapy	NOUN
gs-4321	666	4	plasticity	plasticity	NOUN
gs-4321	666	5	may	may	AUX
gs-4321	666	6	also	also	ADV
gs-4321	666	7	contribute	contribute	VERB
gs-4321	666	8	to	to	ADP
gs-4321	666	9	immunotherapy	immunotherapy	NOUN
gs-4321	666	10	resistance	resistance	NOUN
gs-4321	666	11	by	by	ADP
gs-4321	666	12	reducing	reduce	VERB
gs-4321	666	13	antigen	antigen	ADJ
gs-4321	666	14	presentation	presentation	NOUN
gs-4321	666	15	or	or	CCONJ
gs-4321	666	16	enabling	enable	VERB
gs-4321	666	17	immune	immune	ADJ
gs-4321	666	18	evasion	evasion	NOUN
gs-4321	666	19	.	.	PUNCT
gs-4321	667	1	dedifferentiated	dedifferentiate	VERB
gs-4321	667	2	phenotypes	phenotype	NOUN
gs-4321	667	3	often	often	ADV
gs-4321	667	4	downregulate	downregulate	PROPN
gs-4321	667	5	mhc	mhc	PROPN
gs-4321	667	6	class	class	PROPN
gs-4321	667	7	i	i	PROPN
gs-4321	667	8	genes	gene	VERB
gs-4321	667	9	and	and	CCONJ
gs-4321	667	10	interfere	interfere	VERB
gs-4321	667	11	with	with	ADP
gs-4321	667	12	t	t	NOUN
gs-4321	667	13	-	-	PUNCT
gs-4321	667	14	cell	cell	NOUN
gs-4321	667	15	recognition	recognition	NOUN
gs-4321	667	16	(	(	PUNCT
gs-4321	667	17	jerby	jerby	NOUN
gs-4321	667	18	-	-	PUNCT
gs-4321	667	19	arnon	arnon	PROPN
gs-4321	667	20	et	et	PROPN
gs-4321	667	21	al	al	PROPN
gs-4321	667	22	.	.	PROPN
gs-4321	667	23	,	,	PUNCT
gs-4321	667	24	2018	2018	NUM
gs-4321	667	25	)	)	PUNCT
gs-4321	667	26	.	.	PUNCT
gs-4321	668	1	targeting	target	VERB
gs-4321	668	2	plasticity	plasticity	NOUN
gs-4321	668	3	in	in	ADP
gs-4321	668	4	combination	combination	NOUN
gs-4321	668	5	with	with	ADP
gs-4321	668	6	pd-1	pd-1	ADJ
gs-4321	668	7	or	or	CCONJ
gs-4321	668	8	ctla-4	ctla-4	NOUN
gs-4321	668	9	inhibitors	inhibitor	NOUN
gs-4321	668	10	may	may	AUX
gs-4321	668	11	enhance	enhance	VERB
gs-4321	668	12	immunotherapy	immunotherapy	NOUN
gs-4321	668	13	effectiveness	effectiveness	NOUN
gs-4321	668	14	.	.	PUNCT
gs-4321	669	1	our	our	PRON
gs-4321	669	2	findings	finding	NOUN
gs-4321	669	3	suggest	suggest	VERB
gs-4321	669	4	that	that	SCONJ
gs-4321	669	5	patients	patient	NOUN
gs-4321	669	6	with	with	ADP
gs-4321	669	7	enriched	enriched	ADJ
gs-4321	669	8	intermediate	intermediate	ADJ
gs-4321	669	9	or	or	CCONJ
gs-4321	669	10	stem	stem	NOUN
gs-4321	669	11	-	-	PUNCT
gs-4321	669	12	like	like	ADJ
gs-4321	669	13	populations	population	NOUN
gs-4321	669	14	might	might	AUX
gs-4321	669	15	particularly	particularly	ADV
gs-4321	669	16	benefit	benefit	VERB
gs-4321	669	17	from	from	ADP
gs-4321	669	18	such	such	ADJ
gs-4321	669	19	combination	combination	NOUN
gs-4321	669	20	approaches	approach	NOUN
gs-4321	669	21	.	.	PUNCT
gs-4321	670	1	biomarker	biomarker	NOUN
gs-4321	670	2	development	development	NOUN
gs-4321	670	3	the	the	DET
gs-4321	670	4	regulatory	regulatory	ADJ
gs-4321	670	5	factors	factor	NOUN
gs-4321	670	6	,	,	PUNCT
gs-4321	670	7	signaling	signal	VERB
gs-4321	670	8	pathways	pathway	NOUN
gs-4321	670	9	,	,	PUNCT
gs-4321	670	10	and	and	CCONJ
gs-4321	670	11	metabolic	metabolic	NOUN
gs-4321	670	12	features	feature	NOUN
gs-4321	670	13	identified	identify	VERB
gs-4321	670	14	in	in	ADP
gs-4321	670	15	our	our	PRON
gs-4321	670	16	study	study	NOUN
gs-4321	670	17	may	may	AUX
gs-4321	670	18	serve	serve	VERB
gs-4321	670	19	as	as	ADP
gs-4321	670	20	biomarkers	biomarker	NOUN
gs-4321	670	21	to	to	PART
gs-4321	670	22	detect	detect	VERB
gs-4321	670	23	adaptive	adaptive	ADJ
gs-4321	670	24	states	state	NOUN
gs-4321	670	25	.	.	PUNCT
gs-4321	671	1	for	for	ADP
gs-4321	671	2	instance	instance	NOUN
gs-4321	671	3	,	,	PUNCT
gs-4321	671	4	elevated	elevated	ADJ
gs-4321	671	5	stat3	stat3	PROPN
gs-4321	671	6	,	,	PUNCT
gs-4321	671	7	jun	jun	PROPN
gs-4321	671	8	,	,	PUNCT
gs-4321	671	9	or	or	CCONJ
gs-4321	671	10	sox2	sox2	NOUN
gs-4321	671	11	activity	activity	NOUN
gs-4321	671	12	could	could	AUX
gs-4321	671	13	mark	mark	VERB
gs-4321	671	14	plastic	plastic	ADJ
gs-4321	671	15	populations	population	NOUN
gs-4321	671	16	in	in	ADP
gs-4321	671	17	biopsy	biopsy	NOUN
gs-4321	671	18	samples	sample	NOUN
gs-4321	671	19	.	.	PUNCT
gs-4321	672	1	similarly	similarly	ADV
gs-4321	672	2	,	,	PUNCT
gs-4321	672	3	signaling	signal	VERB
gs-4321	672	4	signatures	signature	NOUN
gs-4321	672	5	involving	involve	VERB
gs-4321	672	6	il-6	il-6	NOUN
gs-4321	672	7	or	or	CCONJ
gs-4321	672	8	tgf	tgf	PROPN
gs-4321	672	9	may	may	AUX
gs-4321	672	10	indicate	indicate	VERB
gs-4321	672	11	microenvironmental	microenvironmental	ADJ
gs-4321	672	12	niches	niche	NOUN
gs-4321	672	13	that	that	PRON
gs-4321	672	14	promote	promote	VERB
gs-4321	672	15	adaptation	adaptation	NOUN
gs-4321	672	16	.	.	PUNCT
gs-4321	673	1	these	these	DET
gs-4321	673	2	markers	marker	NOUN
gs-4321	673	3	could	could	AUX
gs-4321	673	4	be	be	AUX
gs-4321	673	5	incorporated	incorporate	VERB
gs-4321	673	6	into	into	ADP
gs-4321	673	7	multiomic	multiomic	ADJ
gs-4321	673	8	diagnostic	diagnostic	ADJ
gs-4321	673	9	pipelines	pipeline	NOUN
gs-4321	673	10	for	for	ADP
gs-4321	673	11	patient	patient	ADJ
gs-4321	673	12	stratification	stratification	NOUN
gs-4321	673	13	.	.	PUNCT
gs-4321	674	1	importance	importance	NOUN
gs-4321	674	2	of	of	ADP
gs-4321	674	3	targeting	target	VERB
gs-4321	674	4	transitional	transitional	ADJ
gs-4321	674	5	states	state	NOUN
gs-4321	674	6	our	our	PRON
gs-4321	674	7	analyses	analysis	NOUN
gs-4321	674	8	suggest	suggest	VERB
gs-4321	674	9	that	that	SCONJ
gs-4321	674	10	intermediate	intermediate	ADJ
gs-4321	674	11	states	state	NOUN
gs-4321	674	12	represent	represent	VERB
gs-4321	674	13	crucial	crucial	ADJ
gs-4321	674	14	points	point	NOUN
gs-4321	674	15	at	at	ADP
gs-4321	674	16	which	which	PRON
gs-4321	674	17	therapeutic	therapeutic	ADJ
gs-4321	674	18	intervention	intervention	NOUN
gs-4321	674	19	may	may	AUX
gs-4321	674	20	be	be	AUX
gs-4321	674	21	most	most	ADV
gs-4321	674	22	effective	effective	ADJ
gs-4321	674	23	.	.	PUNCT
gs-4321	675	1	because	because	SCONJ
gs-4321	675	2	these	these	DET
gs-4321	675	3	states	state	NOUN
gs-4321	675	4	precede	precede	VERB
gs-4321	675	5	stable	stable	ADJ
gs-4321	675	6	resistance	resistance	NOUN
gs-4321	675	7	phenotypes	phenotype	NOUN
gs-4321	675	8	,	,	PUNCT
gs-4321	675	9	targeting	target	VERB
gs-4321	675	10	them	they	PRON
gs-4321	675	11	early	early	ADV
gs-4321	675	12	may	may	AUX
gs-4321	675	13	prevent	prevent	VERB
gs-4321	675	14	full	full	ADJ
gs-4321	675	15	transition	transition	NOUN
gs-4321	675	16	to	to	PART
gs-4321	675	17	stem	stem	VERB
gs-4321	675	18	-	-	PUNCT
gs-4321	675	19	like	like	ADJ
gs-4321	675	20	or	or	CCONJ
gs-4321	675	21	stress	stress	NOUN
gs-4321	675	22	-	-	PUNCT
gs-4321	675	23	tolerant	tolerant	ADJ
gs-4321	675	24	identities	identity	NOUN
gs-4321	675	25	.	.	PUNCT
gs-4321	676	1	drugs	drug	NOUN
gs-4321	676	2	that	that	PRON
gs-4321	676	3	disrupt	disrupt	VERB
gs-4321	676	4	regulatory	regulatory	ADJ
gs-4321	676	5	hubs	hub	NOUN
gs-4321	676	6	,	,	PUNCT
gs-4321	676	7	epigenetic	epigenetic	ADJ
gs-4321	676	8	modifiers	modifier	NOUN
gs-4321	676	9	,	,	PUNCT
gs-4321	676	10	or	or	CCONJ
gs-4321	676	11	microenvironmental	microenvironmental	ADJ
gs-4321	676	12	drivers	driver	NOUN
gs-4321	676	13	may	may	AUX
gs-4321	676	14	be	be	AUX
gs-4321	676	15	particularly	particularly	ADV
gs-4321	676	16	effective	effective	ADJ
gs-4321	676	17	during	during	ADP
gs-4321	676	18	these	these	DET
gs-4321	676	19	transitional	transitional	ADJ
gs-4321	676	20	windows	window	NOUN
gs-4321	676	21	.	.	PUNCT
gs-4321	677	1	future	future	ADJ
gs-4321	677	2	directions	direction	NOUN
gs-4321	677	3	in	in	ADP
gs-4321	677	4	translational	translational	ADJ
gs-4321	677	5	research	research	NOUN
gs-4321	677	6	future	future	ADJ
gs-4321	677	7	translational	translational	ADJ
gs-4321	677	8	research	research	NOUN
gs-4321	677	9	should	should	AUX
gs-4321	677	10	focus	focus	VERB
gs-4321	677	11	on	on	ADP
gs-4321	677	12	validating	validate	VERB
gs-4321	677	13	plasticity	plasticity	NOUN
gs-4321	677	14	-	-	PUNCT
gs-4321	677	15	associated	associate	VERB
gs-4321	677	16	regulators	regulator	NOUN
gs-4321	677	17	in	in	ADP
gs-4321	677	18	patient	patient	NOUN
gs-4321	677	19	-	-	PUNCT
gs-4321	677	20	derived	derive	VERB
gs-4321	677	21	organoids	organoid	NOUN
gs-4321	677	22	,	,	PUNCT
gs-4321	677	23	xenografts	xenograft	NOUN
gs-4321	677	24	,	,	PUNCT
gs-4321	677	25	and	and	CCONJ
gs-4321	677	26	ex	ex	PRON
gs-4321	677	27	vivo	vivo	ADJ
gs-4321	677	28	tumor	tumor	NOUN
gs-4321	677	29	slices	slice	NOUN
gs-4321	677	30	.	.	PUNCT
gs-4321	678	1	these	these	DET
gs-4321	678	2	model	model	NOUN
gs-4321	678	3	systems	system	NOUN
gs-4321	678	4	allow	allow	VERB
gs-4321	678	5	precise	precise	ADJ
gs-4321	678	6	manipulation	manipulation	NOUN
gs-4321	678	7	of	of	ADP
gs-4321	678	8	microenvironmental	microenvironmental	ADJ
gs-4321	678	9	conditions	condition	NOUN
gs-4321	678	10	and	and	CCONJ
gs-4321	678	11	facilitate	facilitate	NOUN
gs-4321	678	12	testing	testing	NOUN
gs-4321	678	13	of	of	ADP
gs-4321	678	14	combination	combination	NOUN
gs-4321	678	15	therapies	therapy	NOUN
gs-4321	678	16	targeting	target	VERB
gs-4321	678	17	plasticity	plasticity	NOUN
gs-4321	678	18	.	.	PUNCT
gs-4321	679	1	integrating	integrate	VERB
gs-4321	679	2	clinical	clinical	ADJ
gs-4321	679	3	single	single	ADJ
gs-4321	679	4	-	-	PUNCT
gs-4321	679	5	cell	cell	NOUN
gs-4321	679	6	datasets	dataset	NOUN
gs-4321	679	7	with	with	ADP
gs-4321	679	8	longitudinal	longitudinal	ADJ
gs-4321	679	9	patient	patient	ADJ
gs-4321	679	10	outcomes	outcome	NOUN
gs-4321	679	11	will	will	AUX
gs-4321	679	12	be	be	AUX
gs-4321	679	13	critical	critical	ADJ
gs-4321	679	14	for	for	ADP
gs-4321	679	15	evaluating	evaluate	VERB
gs-4321	679	16	the	the	DET
gs-4321	679	17	predictive	predictive	ADJ
gs-4321	679	18	value	value	NOUN
gs-4321	679	19	of	of	ADP
gs-4321	679	20	plasticity	plasticity	NOUN
gs-4321	679	21	markers	marker	NOUN
gs-4321	679	22	.	.	PUNCT
gs-4321	680	1	toward	toward	ADP
gs-4321	680	2	a	a	DET
gs-4321	680	3	unified	unified	ADJ
gs-4321	680	4	model	model	NOUN
gs-4321	680	5	of	of	ADP
gs-4321	680	6	tumor	tumor	NOUN
gs-4321	680	7	plasticity	plasticity	VERB
gs-4321	680	8	the	the	DET
gs-4321	680	9	results	result	NOUN
gs-4321	680	10	of	of	ADP
gs-4321	680	11	this	this	DET
gs-4321	680	12	study	study	NOUN
gs-4321	680	13	contribute	contribute	VERB
gs-4321	680	14	to	to	ADP
gs-4321	680	15	a	a	DET
gs-4321	680	16	growing	grow	VERB
gs-4321	680	17	body	body	NOUN
gs-4321	680	18	of	of	ADP
gs-4321	680	19	work	work	NOUN
gs-4321	680	20	suggesting	suggest	VERB
gs-4321	680	21	that	that	SCONJ
gs-4321	680	22	tumor	tumor	NOUN
gs-4321	680	23	plasticity	plasticity	NOUN
gs-4321	680	24	arises	arise	VERB
gs-4321	680	25	from	from	ADP
gs-4321	680	26	the	the	DET
gs-4321	680	27	integration	integration	NOUN
gs-4321	680	28	of	of	ADP
gs-4321	680	29	multi	multi	ADJ
gs-4321	680	30	-	-	ADJ
gs-4321	680	31	layer	layer	ADJ
gs-4321	680	32	regulatory	regulatory	ADJ
gs-4321	680	33	systems	system	NOUN
gs-4321	680	34	.	.	PUNCT
gs-4321	681	1	our	our	PRON
gs-4321	681	2	data	datum	NOUN
gs-4321	681	3	demonstrate	demonstrate	VERB
gs-4321	681	4	that	that	SCONJ
gs-4321	681	5	differentiated	differentiated	ADJ
gs-4321	681	6	,	,	PUNCT
gs-4321	681	7	intermediate	intermediate	ADJ
gs-4321	681	8	,	,	PUNCT
gs-4321	681	9	and	and	CCONJ
gs-4321	681	10	stem	stem	NOUN
gs-4321	681	11	-	-	PUNCT
gs-4321	681	12	like	like	ADJ
gs-4321	681	13	states	state	NOUN
gs-4321	681	14	form	form	VERB
gs-4321	681	15	a	a	DET
gs-4321	681	16	structured	structured	ADJ
gs-4321	681	17	continuum	continuum	NOUN
gs-4321	681	18	shaped	shape	VERB
gs-4321	681	19	by	by	ADP
gs-4321	681	20	transcriptional	transcriptional	ADJ
gs-4321	681	21	identity	identity	NOUN
gs-4321	681	22	,	,	PUNCT
gs-4321	681	23	regulatory	regulatory	ADJ
gs-4321	681	24	network	network	NOUN
gs-4321	681	25	activity	activity	NOUN
gs-4321	681	26	,	,	PUNCT
gs-4321	681	27	microenvironmental	microenvironmental	ADJ
gs-4321	681	28	signaling	signaling	NOUN
gs-4321	681	29	,	,	PUNCT
gs-4321	681	30	and	and	CCONJ
gs-4321	681	31	evolutionary	evolutionary	ADJ
gs-4321	681	32	constraints	constraint	NOUN
gs-4321	681	33	.	.	PUNCT
gs-4321	682	1	this	this	DET
gs-4321	682	2	unified	unified	ADJ
gs-4321	682	3	model	model	NOUN
gs-4321	682	4	provides	provide	VERB
gs-4321	682	5	a	a	DET
gs-4321	682	6	georgian	georgian	NOUN
gs-4321	682	7	scientists/	scientists/	NUM
gs-4321	682	8	.	.	PUNCT
gs-4321	683	1	7	7	NUM
gs-4321	683	2	n	n	DET
gs-4321	683	3	4	4	NUM
gs-4321	683	4	,	,	PUNCT
gs-4321	683	5	2025	2025	NUM
gs-4321	683	6	375	375	NUM
gs-4321	683	7	conceptual	conceptual	ADJ
gs-4321	683	8	framework	framework	NOUN
gs-4321	683	9	for	for	ADP
gs-4321	683	10	understanding	understand	VERB
gs-4321	683	11	how	how	SCONJ
gs-4321	683	12	malignant	malignant	ADJ
gs-4321	683	13	populations	population	NOUN
gs-4321	683	14	adapt	adapt	VERB
gs-4321	683	15	to	to	ADP
gs-4321	683	16	therapeutic	therapeutic	ADJ
gs-4321	683	17	and	and	CCONJ
gs-4321	683	18	ecological	ecological	ADJ
gs-4321	683	19	pressures	pressure	NOUN
gs-4321	683	20	.	.	PUNCT
gs-4321	684	1	implications	implication	NOUN
gs-4321	684	2	for	for	ADP
gs-4321	684	3	precision	precision	NOUN
gs-4321	684	4	oncology	oncology	NOUN
gs-4321	684	5	integrating	integrate	VERB
gs-4321	684	6	plasticity	plasticity	NOUN
gs-4321	684	7	into	into	ADP
gs-4321	684	8	precision	precision	NOUN
gs-4321	684	9	oncology	oncology	NOUN
gs-4321	684	10	frameworks	framework	NOUN
gs-4321	684	11	could	could	AUX
gs-4321	684	12	greatly	greatly	ADV
gs-4321	684	13	enhance	enhance	VERB
gs-4321	684	14	treatment	treatment	NOUN
gs-4321	684	15	design	design	NOUN
gs-4321	684	16	.	.	PUNCT
gs-4321	685	1	for	for	ADP
gs-4321	685	2	instance	instance	NOUN
gs-4321	685	3	,	,	PUNCT
gs-4321	685	4	identifying	identify	VERB
gs-4321	685	5	the	the	DET
gs-4321	685	6	dominant	dominant	ADJ
gs-4321	685	7	state	state	NOUN
gs-4321	685	8	of	of	ADP
gs-4321	685	9	a	a	DET
gs-4321	685	10	patient	patient	NOUN
gs-4321	685	11	’s	’s	PART
gs-4321	685	12	tumor	tumor	NOUN
gs-4321	685	13	—	—	PUNCT
gs-4321	685	14	whether	whether	SCONJ
gs-4321	685	15	differentiated	differentiated	ADJ
gs-4321	685	16	,	,	PUNCT
gs-4321	685	17	intermediate	intermediate	ADJ
gs-4321	685	18	,	,	PUNCT
gs-4321	685	19	or	or	CCONJ
gs-4321	685	20	stem	stem	NOUN
gs-4321	685	21	-	-	PUNCT
gs-4321	685	22	like	like	NOUN
gs-4321	685	23	—	—	PUNCT
gs-4321	685	24	may	may	AUX
gs-4321	685	25	inform	inform	VERB
gs-4321	685	26	therapeutic	therapeutic	ADJ
gs-4321	685	27	choices	choice	NOUN
gs-4321	685	28	.	.	PUNCT
gs-4321	686	1	patients	patient	NOUN
gs-4321	686	2	with	with	ADP
gs-4321	686	3	tumors	tumor	NOUN
gs-4321	686	4	enriched	enrich	VERB
gs-4321	686	5	for	for	ADP
gs-4321	686	6	intermediate	intermediate	ADJ
gs-4321	686	7	states	state	NOUN
gs-4321	686	8	may	may	AUX
gs-4321	686	9	benefit	benefit	VERB
gs-4321	686	10	from	from	ADP
gs-4321	686	11	combination	combination	NOUN
gs-4321	686	12	therapies	therapy	NOUN
gs-4321	686	13	targeting	target	VERB
gs-4321	686	14	both	both	CCONJ
gs-4321	686	15	microenvironmental	microenvironmental	ADJ
gs-4321	686	16	and	and	CCONJ
gs-4321	686	17	epigenetic	epigenetic	ADJ
gs-4321	686	18	regulators	regulator	NOUN
gs-4321	686	19	.	.	PUNCT
gs-4321	687	1	meanwhile	meanwhile	ADV
gs-4321	687	2	,	,	PUNCT
gs-4321	687	3	tumors	tumor	NOUN
gs-4321	687	4	dominated	dominate	VERB
gs-4321	687	5	by	by	ADP
gs-4321	687	6	stem	stem	NOUN
gs-4321	687	7	-	-	PUNCT
gs-4321	687	8	like	like	ADJ
gs-4321	687	9	cells	cell	NOUN
gs-4321	687	10	may	may	AUX
gs-4321	687	11	require	require	VERB
gs-4321	687	12	strategies	strategy	NOUN
gs-4321	687	13	that	that	PRON
gs-4321	687	14	disrupt	disrupt	VERB
gs-4321	687	15	survival	survival	NOUN
gs-4321	687	16	pathways	pathway	NOUN
gs-4321	687	17	and	and	CCONJ
gs-4321	687	18	lineage	lineage	NOUN
gs-4321	687	19	plasticity	plasticity	NOUN
gs-4321	687	20	mechanisms	mechanism	NOUN
gs-4321	687	21	.	.	PUNCT
gs-4321	688	1	limitations	limitation	NOUN
gs-4321	688	2	and	and	CCONJ
gs-4321	688	3	opportunities	opportunity	NOUN
gs-4321	688	4	while	while	SCONJ
gs-4321	688	5	comprehensive	comprehensive	ADJ
gs-4321	688	6	,	,	PUNCT
gs-4321	688	7	our	our	PRON
gs-4321	688	8	study	study	NOUN
gs-4321	688	9	has	have	VERB
gs-4321	688	10	limitations	limitation	NOUN
gs-4321	688	11	.	.	PUNCT
gs-4321	689	1	single	single	ADJ
gs-4321	689	2	-	-	PUNCT
gs-4321	689	3	cell	cell	NOUN
gs-4321	689	4	transcriptional	transcriptional	NOUN
gs-4321	689	5	data	datum	NOUN
gs-4321	689	6	provide	provide	VERB
gs-4321	689	7	indirect	indirect	ADJ
gs-4321	689	8	measures	measure	NOUN
gs-4321	689	9	of	of	ADP
gs-4321	689	10	regulatory	regulatory	ADJ
gs-4321	689	11	and	and	CCONJ
gs-4321	689	12	signaling	signal	VERB
gs-4321	689	13	activity	activity	NOUN
gs-4321	689	14	.	.	PUNCT
gs-4321	690	1	integrating	integrate	VERB
gs-4321	690	2	proteomic	proteomic	ADJ
gs-4321	690	3	and	and	CCONJ
gs-4321	690	4	epigenomic	epigenomic	ADJ
gs-4321	690	5	single	single	ADJ
gs-4321	690	6	-	-	PUNCT
gs-4321	690	7	cell	cell	NOUN
gs-4321	690	8	modalities	modality	NOUN
gs-4321	690	9	will	will	AUX
gs-4321	690	10	be	be	AUX
gs-4321	690	11	essential	essential	ADJ
gs-4321	690	12	to	to	PART
gs-4321	690	13	validate	validate	VERB
gs-4321	690	14	key	key	ADJ
gs-4321	690	15	regulators	regulator	NOUN
gs-4321	690	16	.	.	PUNCT
gs-4321	691	1	additionally	additionally	ADV
gs-4321	691	2	,	,	PUNCT
gs-4321	691	3	dynamic	dynamic	ADJ
gs-4321	691	4	studies	study	NOUN
gs-4321	691	5	are	be	AUX
gs-4321	691	6	needed	need	VERB
gs-4321	691	7	to	to	PART
gs-4321	691	8	confirm	confirm	VERB
gs-4321	691	9	that	that	SCONJ
gs-4321	691	10	inferred	infer	VERB
gs-4321	691	11	trajectories	trajectory	NOUN
gs-4321	691	12	represent	represent	VERB
gs-4321	691	13	true	true	ADJ
gs-4321	691	14	temporal	temporal	ADJ
gs-4321	691	15	transitions	transition	NOUN
gs-4321	691	16	.	.	PUNCT
gs-4321	692	1	despite	despite	SCONJ
gs-4321	692	2	these	these	DET
gs-4321	692	3	limitations	limitation	NOUN
gs-4321	692	4	,	,	PUNCT
gs-4321	692	5	the	the	DET
gs-4321	692	6	consistency	consistency	NOUN
gs-4321	692	7	of	of	ADP
gs-4321	692	8	our	our	PRON
gs-4321	692	9	findings	finding	NOUN
gs-4321	692	10	with	with	ADP
gs-4321	692	11	prior	prior	ADJ
gs-4321	692	12	studies	study	NOUN
gs-4321	692	13	across	across	ADP
gs-4321	692	14	multiple	multiple	ADJ
gs-4321	692	15	tumor	tumor	NOUN
gs-4321	692	16	types	type	NOUN
gs-4321	692	17	strengthens	strengthen	VERB
gs-4321	692	18	the	the	DET
gs-4321	692	19	biological	biological	ADJ
gs-4321	692	20	validity	validity	NOUN
gs-4321	692	21	of	of	ADP
gs-4321	692	22	the	the	DET
gs-4321	692	23	conclusions	conclusion	NOUN
gs-4321	692	24	.	.	PUNCT
gs-4321	693	1	final	final	ADJ
gs-4321	693	2	remarks	remark	NOUN
gs-4321	693	3	plasticity	plasticity	NOUN
gs-4321	693	4	represents	represent	VERB
gs-4321	693	5	a	a	DET
gs-4321	693	6	fundamental	fundamental	ADJ
gs-4321	693	7	challenge	challenge	NOUN
gs-4321	693	8	in	in	ADP
gs-4321	693	9	cancer	cancer	NOUN
gs-4321	693	10	treatment	treatment	NOUN
gs-4321	693	11	,	,	PUNCT
gs-4321	693	12	enabling	enable	VERB
gs-4321	693	13	malignant	malignant	ADJ
gs-4321	693	14	cells	cell	NOUN
gs-4321	693	15	to	to	PART
gs-4321	693	16	survive	survive	VERB
gs-4321	693	17	therapeutic	therapeutic	ADJ
gs-4321	693	18	pressure	pressure	NOUN
gs-4321	693	19	,	,	PUNCT
gs-4321	693	20	evade	evade	VERB
gs-4321	693	21	immune	immune	ADJ
gs-4321	693	22	surveillance	surveillance	NOUN
gs-4321	693	23	,	,	PUNCT
gs-4321	693	24	and	and	CCONJ
gs-4321	693	25	initiate	initiate	VERB
gs-4321	693	26	metastatic	metastatic	ADJ
gs-4321	693	27	dissemination	dissemination	NOUN
gs-4321	693	28	.	.	PUNCT
gs-4321	694	1	our	our	PRON
gs-4321	694	2	integrative	integrative	ADJ
gs-4321	694	3	analysis	analysis	NOUN
gs-4321	694	4	highlights	highlight	NOUN
gs-4321	694	5	the	the	DET
gs-4321	694	6	mechanistic	mechanistic	ADJ
gs-4321	694	7	complexity	complexity	NOUN
gs-4321	694	8	of	of	ADP
gs-4321	694	9	this	this	DET
gs-4321	694	10	phenomenon	phenomenon	NOUN
gs-4321	694	11	and	and	CCONJ
gs-4321	694	12	identifies	identify	VERB
gs-4321	694	13	key	key	ADJ
gs-4321	694	14	nodes	node	NOUN
gs-4321	694	15	within	within	ADP
gs-4321	694	16	regulatory	regulatory	ADJ
gs-4321	694	17	and	and	CCONJ
gs-4321	694	18	signaling	signal	VERB
gs-4321	694	19	networks	network	NOUN
gs-4321	694	20	that	that	PRON
gs-4321	694	21	may	may	AUX
gs-4321	694	22	serve	serve	VERB
gs-4321	694	23	as	as	ADP
gs-4321	694	24	therapeutic	therapeutic	ADJ
gs-4321	694	25	targets	target	NOUN
gs-4321	694	26	.	.	PUNCT
gs-4321	695	1	continued	continue	VERB
gs-4321	695	2	development	development	NOUN
gs-4321	695	3	of	of	ADP
gs-4321	695	4	single	single	ADJ
gs-4321	695	5	-	-	PUNCT
gs-4321	695	6	cell	cell	NOUN
gs-4321	695	7	technologies	technology	NOUN
gs-4321	695	8	and	and	CCONJ
gs-4321	695	9	computational	computational	ADJ
gs-4321	695	10	models	model	NOUN
gs-4321	695	11	will	will	AUX
gs-4321	695	12	be	be	AUX
gs-4321	695	13	essential	essential	ADJ
gs-4321	695	14	to	to	PART
gs-4321	695	15	fully	fully	ADV
gs-4321	695	16	resolve	resolve	VERB
gs-4321	695	17	the	the	DET
gs-4321	695	18	mechanisms	mechanism	NOUN
gs-4321	695	19	underlying	underlie	VERB
gs-4321	695	20	plasticity	plasticity	NOUN
gs-4321	695	21	.	.	PUNCT
gs-4321	696	1	ultimately	ultimately	ADV
gs-4321	696	2	,	,	PUNCT
gs-4321	696	3	translating	translate	VERB
gs-4321	696	4	these	these	DET
gs-4321	696	5	insights	insight	NOUN
gs-4321	696	6	into	into	ADP
gs-4321	696	7	clinical	clinical	ADJ
gs-4321	696	8	interventions	intervention	NOUN
gs-4321	696	9	holds	hold	VERB
gs-4321	696	10	promise	promise	NOUN
gs-4321	696	11	for	for	ADP
gs-4321	696	12	improving	improve	VERB
gs-4321	696	13	patient	patient	ADJ
gs-4321	696	14	outcomes	outcome	NOUN
gs-4321	696	15	and	and	CCONJ
gs-4321	696	16	overcoming	overcome	VERB
gs-4321	696	17	therapy	therapy	NOUN
gs-4321	696	18	resistance	resistance	NOUN
gs-4321	696	19	.	.	PUNCT
gs-4321	697	1	conclusions	conclusion	NOUN
gs-4321	697	2	the	the	DET
gs-4321	697	3	present	present	ADJ
gs-4321	697	4	study	study	NOUN
gs-4321	697	5	provides	provide	VERB
gs-4321	697	6	a	a	DET
gs-4321	697	7	comprehensive	comprehensive	ADJ
gs-4321	697	8	and	and	CCONJ
gs-4321	697	9	integrative	integrative	ADJ
gs-4321	697	10	bioinformatics	bioinformatics	NOUN
gs-4321	697	11	framework	framework	NOUN
gs-4321	697	12	that	that	PRON
gs-4321	697	13	significantly	significantly	ADV
gs-4321	697	14	advances	advance	VERB
gs-4321	697	15	current	current	ADJ
gs-4321	697	16	understanding	understanding	NOUN
gs-4321	697	17	of	of	ADP
gs-4321	697	18	tumor	tumor	NOUN
gs-4321	697	19	microenvironment	microenvironment	ADJ
gs-4321	697	20	complexity	complexity	NOUN
gs-4321	697	21	,	,	PUNCT
gs-4321	697	22	cancer	cancer	NOUN
gs-4321	697	23	cell	cell	NOUN
gs-4321	697	24	plasticity	plasticity	NOUN
gs-4321	697	25	,	,	PUNCT
gs-4321	697	26	and	and	CCONJ
gs-4321	697	27	the	the	DET
gs-4321	697	28	multilayered	multilayered	ADJ
gs-4321	697	29	regulatory	regulatory	ADJ
gs-4321	697	30	architecture	architecture	NOUN
gs-4321	697	31	that	that	PRON
gs-4321	697	32	governs	govern	VERB
gs-4321	697	33	malignant	malignant	ADJ
gs-4321	697	34	state	state	NOUN
gs-4321	697	35	transitions	transition	NOUN
gs-4321	697	36	.	.	PUNCT
gs-4321	698	1	by	by	ADP
gs-4321	698	2	synthesizing	synthesize	VERB
gs-4321	698	3	multi	multi	ADJ
gs-4321	698	4	-	-	ADJ
gs-4321	698	5	omics	omics	ADJ
gs-4321	698	6	single	single	ADJ
gs-4321	698	7	-	-	PUNCT
gs-4321	698	8	cell	cell	NOUN
gs-4321	698	9	data	datum	NOUN
gs-4321	698	10	with	with	ADP
gs-4321	698	11	advanced	advanced	ADJ
gs-4321	698	12	computational	computational	ADJ
gs-4321	698	13	modeling	modeling	NOUN
gs-4321	698	14	,	,	PUNCT
gs-4321	698	15	we	we	PRON
gs-4321	698	16	demonstrate	demonstrate	VERB
gs-4321	698	17	that	that	SCONJ
gs-4321	698	18	tumor	tumor	NOUN
gs-4321	698	19	ecosystems	ecosystem	NOUN
gs-4321	698	20	are	be	AUX
gs-4321	698	21	structured	structure	VERB
gs-4321	698	22	around	around	ADP
gs-4321	698	23	dynamic	dynamic	ADJ
gs-4321	698	24	,	,	PUNCT
gs-4321	698	25	nonlinear	nonlinear	ADJ
gs-4321	698	26	,	,	PUNCT
gs-4321	698	27	and	and	CCONJ
gs-4321	698	28	reversible	reversible	ADJ
gs-4321	698	29	phenotypic	phenotypic	NOUN
gs-4321	698	30	continua	continuum	NOUN
gs-4321	698	31	rather	rather	ADV
gs-4321	698	32	than	than	ADP
gs-4321	698	33	fixed	fix	VERB
gs-4321	698	34	cellular	cellular	ADJ
gs-4321	698	35	hierarchies	hierarchy	NOUN
gs-4321	698	36	.	.	PUNCT
gs-4321	699	1	the	the	DET
gs-4321	699	2	identification	identification	NOUN
gs-4321	699	3	of	of	ADP
gs-4321	699	4	differentiated	differentiated	ADJ
gs-4321	699	5	,	,	PUNCT
gs-4321	699	6	intermediate	intermediate	ADJ
gs-4321	699	7	,	,	PUNCT
gs-4321	699	8	and	and	CCONJ
gs-4321	699	9	stem	stem	NOUN
gs-4321	699	10	-	-	PUNCT
gs-4321	699	11	like	like	ADJ
gs-4321	699	12	malignant	malignant	ADJ
gs-4321	699	13	states	state	NOUN
gs-4321	699	14	across	across	ADP
gs-4321	699	15	diverse	diverse	ADJ
gs-4321	699	16	tumor	tumor	NOUN
gs-4321	699	17	types	type	NOUN
gs-4321	699	18	highlights	highlight	VERB
gs-4321	699	19	the	the	DET
gs-4321	699	20	universality	universality	NOUN
gs-4321	699	21	of	of	ADP
gs-4321	699	22	adaptive	adaptive	ADJ
gs-4321	699	23	plasticity	plasticity	NOUN
gs-4321	699	24	in	in	ADP
gs-4321	699	25	cancer	cancer	NOUN
gs-4321	699	26	biology	biology	NOUN
gs-4321	699	27	,	,	PUNCT
gs-4321	699	28	emphasizing	emphasize	VERB
gs-4321	699	29	that	that	SCONJ
gs-4321	699	30	adaptability	adaptability	NOUN
gs-4321	699	31	is	be	AUX
gs-4321	699	32	an	an	DET
gs-4321	699	33	intrinsic	intrinsic	ADJ
gs-4321	699	34	evolutionary	evolutionary	ADJ
gs-4321	699	35	advantage	advantage	NOUN
gs-4321	699	36	leveraged	leverage	VERB
gs-4321	699	37	by	by	ADP
gs-4321	699	38	malignant	malignant	ADJ
gs-4321	699	39	populations	population	NOUN
gs-4321	699	40	under	under	ADP
gs-4321	699	41	microenvironmental	microenvironmental	ADJ
gs-4321	699	42	and	and	CCONJ
gs-4321	699	43	therapeutic	therapeutic	ADJ
gs-4321	699	44	pressures	pressure	NOUN
gs-4321	699	45	.	.	PUNCT
gs-4321	700	1	georgian	georgian	NOUN
gs-4321	700	2	scientists/	scientists/	NUM
gs-4321	700	3	.	.	PUNCT
gs-4321	701	1	7	7	NUM
gs-4321	701	2	n	n	DET
gs-4321	701	3	4	4	NUM
gs-4321	701	4	,	,	PUNCT
gs-4321	701	5	2025	2025	NUM
gs-4321	701	6	376	376	NUM
gs-4321	701	7	our	our	PRON
gs-4321	701	8	findings	finding	NOUN
gs-4321	701	9	underscore	underscore	VERB
gs-4321	701	10	the	the	DET
gs-4321	701	11	central	central	ADJ
gs-4321	701	12	role	role	NOUN
gs-4321	701	13	of	of	ADP
gs-4321	701	14	intermediate	intermediate	ADJ
gs-4321	701	15	states	state	NOUN
gs-4321	701	16	as	as	ADP
gs-4321	701	17	pivotal	pivotal	ADJ
gs-4321	701	18	regulators	regulator	NOUN
gs-4321	701	19	of	of	ADP
gs-4321	701	20	phenotypic	phenotypic	ADJ
gs-4321	701	21	flexibility	flexibility	NOUN
gs-4321	701	22	.	.	PUNCT
gs-4321	702	1	these	these	DET
gs-4321	702	2	metastable	metastable	ADJ
gs-4321	702	3	configurations	configuration	NOUN
gs-4321	702	4	,	,	PUNCT
gs-4321	702	5	defined	define	VERB
gs-4321	702	6	by	by	ADP
gs-4321	702	7	elevated	elevated	ADJ
gs-4321	702	8	transcriptional	transcriptional	NOUN
gs-4321	702	9	entropy	entropy	NOUN
gs-4321	702	10	,	,	PUNCT
gs-4321	702	11	partial	partial	ADJ
gs-4321	702	12	activation	activation	NOUN
gs-4321	702	13	of	of	ADP
gs-4321	702	14	lineage	lineage	NOUN
gs-4321	702	15	-	-	PUNCT
gs-4321	702	16	specifying	specify	VERB
gs-4321	702	17	transcription	transcription	NOUN
gs-4321	702	18	factors	factor	NOUN
gs-4321	702	19	,	,	PUNCT
gs-4321	702	20	and	and	CCONJ
gs-4321	702	21	heightened	heighten	VERB
gs-4321	702	22	sensitivity	sensitivity	NOUN
gs-4321	702	23	to	to	ADP
gs-4321	702	24	microenvironment	microenvironment	NOUN
gs-4321	702	25	-	-	PUNCT
gs-4321	702	26	derived	derive	VERB
gs-4321	702	27	cues	cue	NOUN
gs-4321	702	28	,	,	PUNCT
gs-4321	702	29	act	act	VERB
gs-4321	702	30	as	as	ADP
gs-4321	702	31	transitional	transitional	ADJ
gs-4321	702	32	hubs	hub	NOUN
gs-4321	702	33	capable	capable	ADJ
gs-4321	702	34	of	of	ADP
gs-4321	702	35	driving	drive	VERB
gs-4321	702	36	resistance	resistance	NOUN
gs-4321	702	37	,	,	PUNCT
gs-4321	702	38	stemness	stemness	ADJ
gs-4321	702	39	acquisition	acquisition	NOUN
gs-4321	702	40	,	,	PUNCT
gs-4321	702	41	invasion	invasion	NOUN
gs-4321	702	42	,	,	PUNCT
gs-4321	702	43	and	and	CCONJ
gs-4321	702	44	metastatic	metastatic	ADJ
gs-4321	702	45	dissemination	dissemination	NOUN
gs-4321	702	46	.	.	PUNCT
gs-4321	703	1	regulatory	regulatory	ADJ
gs-4321	703	2	network	network	NOUN
gs-4321	703	3	inference	inference	NOUN
gs-4321	703	4	confirms	confirm	VERB
gs-4321	703	5	that	that	SCONJ
gs-4321	703	6	progressive	progressive	ADJ
gs-4321	703	7	activation	activation	NOUN
gs-4321	703	8	of	of	ADP
gs-4321	703	9	key	key	ADJ
gs-4321	703	10	transcription	transcription	NOUN
gs-4321	703	11	factors	factor	NOUN
gs-4321	703	12	—	—	PUNCT
gs-4321	703	13	including	include	VERB
gs-4321	703	14	sox2	sox2	NOUN
gs-4321	703	15	,	,	PUNCT
gs-4321	703	16	mitf	mitf	NOUN
gs-4321	703	17	,	,	PUNCT
gs-4321	703	18	jun	jun	PROPN
gs-4321	703	19	,	,	PUNCT
gs-4321	703	20	and	and	CCONJ
gs-4321	703	21	zeb1	zeb1	PROPN
gs-4321	703	22	—	—	PUNCT
gs-4321	703	23	coordinates	coordinate	VERB
gs-4321	703	24	the	the	DET
gs-4321	703	25	movement	movement	NOUN
gs-4321	703	26	of	of	ADP
gs-4321	703	27	cells	cell	NOUN
gs-4321	703	28	along	along	ADP
gs-4321	703	29	adaptive	adaptive	ADJ
gs-4321	703	30	trajectories	trajectory	NOUN
gs-4321	703	31	,	,	PUNCT
gs-4321	703	32	supported	support	VERB
gs-4321	703	33	by	by	ADP
gs-4321	703	34	epigenetic	epigenetic	ADJ
gs-4321	703	35	remodeling	remodeling	NOUN
gs-4321	703	36	and	and	CCONJ
gs-4321	703	37	metabolic	metabolic	NOUN
gs-4321	703	38	reprogramming	reprogramme	VERB
gs-4321	703	39	that	that	PRON
gs-4321	703	40	collectively	collectively	ADV
gs-4321	703	41	provide	provide	VERB
gs-4321	703	42	a	a	DET
gs-4321	703	43	permissive	permissive	ADJ
gs-4321	703	44	landscape	landscape	NOUN
gs-4321	703	45	for	for	ADP
gs-4321	703	46	rapid	rapid	ADJ
gs-4321	703	47	state	state	NOUN
gs-4321	703	48	transitions	transition	NOUN
gs-4321	703	49	.	.	PUNCT
gs-4321	704	1	equally	equally	ADV
gs-4321	704	2	significant	significant	ADJ
gs-4321	704	3	is	be	AUX
gs-4321	704	4	the	the	DET
gs-4321	704	5	demonstration	demonstration	NOUN
gs-4321	704	6	that	that	PRON
gs-4321	704	7	microenvironmental	microenvironmental	ADJ
gs-4321	704	8	ecosystems	ecosystem	NOUN
gs-4321	704	9	—	—	PUNCT
gs-4321	704	10	including	include	VERB
gs-4321	704	11	cancer	cancer	NOUN
gs-4321	704	12	-	-	PUNCT
gs-4321	704	13	associated	associate	VERB
gs-4321	704	14	fibroblasts	fibroblast	NOUN
gs-4321	704	15	,	,	PUNCT
gs-4321	704	16	macrophages	macrophage	NOUN
gs-4321	704	17	,	,	PUNCT
gs-4321	704	18	endothelial	endothelial	ADJ
gs-4321	704	19	niches	niche	NOUN
gs-4321	704	20	,	,	PUNCT
gs-4321	704	21	and	and	CCONJ
gs-4321	704	22	immune	immune	NOUN
gs-4321	704	23	-	-	PUNCT
gs-4321	704	24	infiltrated	infiltrate	VERB
gs-4321	704	25	compartments	compartment	NOUN
gs-4321	704	26	—	—	PUNCT
gs-4321	704	27	provide	provide	VERB
gs-4321	704	28	the	the	DET
gs-4321	704	29	extrinsic	extrinsic	ADJ
gs-4321	704	30	signals	signal	NOUN
gs-4321	704	31	that	that	PRON
gs-4321	704	32	shape	shape	VERB
gs-4321	704	33	and	and	CCONJ
gs-4321	704	34	reinforce	reinforce	VERB
gs-4321	704	35	adaptive	adaptive	ADJ
gs-4321	704	36	phenotypes	phenotype	NOUN
gs-4321	704	37	.	.	PUNCT
gs-4321	705	1	communication	communication	NOUN
gs-4321	705	2	inference	inference	NOUN
gs-4321	705	3	analyses	analysis	NOUN
gs-4321	705	4	reveal	reveal	VERB
gs-4321	705	5	that	that	SCONJ
gs-4321	705	6	pathways	pathway	NOUN
gs-4321	705	7	such	such	ADJ
gs-4321	705	8	as	as	ADP
gs-4321	705	9	il-6	il-6	NOUN
gs-4321	705	10	/	/	SYM
gs-4321	705	11	stat3	stat3	PROPN
gs-4321	705	12	,	,	PUNCT
gs-4321	705	13	tgf	tgf	PROPN
gs-4321	705	14	/	/	SYM
gs-4321	705	15	tgfbr	tgfbr	PROPN
gs-4321	705	16	,	,	PUNCT
gs-4321	705	17	cxcl12	cxcl12	ADJ
gs-4321	705	18	/	/	SYM
gs-4321	705	19	cxcr4	cxcr4	NOUN
gs-4321	705	20	,	,	PUNCT
gs-4321	705	21	hgf	hgf	NOUN
gs-4321	705	22	/	/	PUNCT
gs-4321	705	23	met	meet	VERB
gs-4321	705	24	,	,	PUNCT
gs-4321	705	25	and	and	CCONJ
gs-4321	705	26	wnt	wnt	PROPN
gs-4321	705	27	/	/	SYM
gs-4321	705	28	frizzled	frizzle	VERB
gs-4321	705	29	orchestrate	orchestrate	ADJ
gs-4321	705	30	lineage	lineage	NOUN
gs-4321	705	31	plasticity	plasticity	NOUN
gs-4321	705	32	,	,	PUNCT
gs-4321	705	33	stemness	stemness	ADJ
gs-4321	705	34	induction	induction	NOUN
gs-4321	705	35	,	,	PUNCT
gs-4321	705	36	epithelial	epithelial	ADJ
gs-4321	705	37	–	–	PUNCT
gs-4321	705	38	mesenchymal	mesenchymal	ADJ
gs-4321	705	39	transitions	transition	NOUN
gs-4321	705	40	,	,	PUNCT
gs-4321	705	41	and	and	CCONJ
gs-4321	705	42	immune	immune	ADJ
gs-4321	705	43	evasion	evasion	NOUN
gs-4321	705	44	.	.	PUNCT
gs-4321	706	1	these	these	DET
gs-4321	706	2	interactions	interaction	NOUN
gs-4321	706	3	are	be	AUX
gs-4321	706	4	spatially	spatially	ADV
gs-4321	706	5	organized	organize	VERB
gs-4321	706	6	within	within	ADP
gs-4321	706	7	distinct	distinct	ADJ
gs-4321	706	8	microenvironmental	microenvironmental	ADJ
gs-4321	706	9	niches	niche	NOUN
gs-4321	706	10	,	,	PUNCT
gs-4321	706	11	illustrating	illustrate	VERB
gs-4321	706	12	that	that	SCONJ
gs-4321	706	13	plasticity	plasticity	NOUN
gs-4321	706	14	emerges	emerge	VERB
gs-4321	706	15	not	not	PART
gs-4321	706	16	merely	merely	ADV
gs-4321	706	17	from	from	ADP
gs-4321	706	18	intrinsic	intrinsic	ADJ
gs-4321	706	19	regulatory	regulatory	ADJ
gs-4321	706	20	circuitry	circuitry	NOUN
gs-4321	706	21	but	but	CCONJ
gs-4321	706	22	from	from	ADP
gs-4321	706	23	an	an	DET
gs-4321	706	24	ecological	ecological	ADJ
gs-4321	706	25	network	network	NOUN
gs-4321	706	26	of	of	ADP
gs-4321	706	27	reciprocal	reciprocal	ADJ
gs-4321	706	28	cross	cross	NOUN
gs-4321	706	29	-	-	ADJ
gs-4321	706	30	talk	talk	NOUN
gs-4321	706	31	across	across	ADP
gs-4321	706	32	tumor	tumor	NOUN
gs-4321	706	33	architecture	architecture	NOUN
gs-4321	706	34	.	.	PUNCT
gs-4321	707	1	this	this	DET
gs-4321	707	2	investigation	investigation	NOUN
gs-4321	707	3	further	further	ADJ
gs-4321	707	4	highlights	highlight	NOUN
gs-4321	707	5	that	that	PRON
gs-4321	707	6	adaptive	adaptive	ADJ
gs-4321	707	7	responses	response	NOUN
gs-4321	707	8	to	to	ADP
gs-4321	707	9	therapeutic	therapeutic	ADJ
gs-4321	707	10	stress	stress	NOUN
gs-4321	707	11	follow	follow	NOUN
gs-4321	707	12	structured	structure	VERB
gs-4321	707	13	,	,	PUNCT
gs-4321	707	14	predictable	predictable	ADJ
gs-4321	707	15	trajectories	trajectory	NOUN
gs-4321	707	16	rather	rather	ADV
gs-4321	707	17	than	than	ADP
gs-4321	707	18	stochastic	stochastic	ADJ
gs-4321	707	19	fluctuations	fluctuation	NOUN
gs-4321	707	20	.	.	PUNCT
gs-4321	708	1	the	the	DET
gs-4321	708	2	directional	directional	ADJ
gs-4321	708	3	flows	flow	NOUN
gs-4321	708	4	observed	observe	VERB
gs-4321	708	5	in	in	ADP
gs-4321	708	6	rna	rna	NOUN
gs-4321	708	7	velocity	velocity	NOUN
gs-4321	708	8	–	–	PUNCT
gs-4321	708	9	inspired	inspire	VERB
gs-4321	708	10	analyses	analysis	NOUN
gs-4321	708	11	and	and	CCONJ
gs-4321	708	12	the	the	DET
gs-4321	708	13	alignment	alignment	NOUN
gs-4321	708	14	with	with	ADP
gs-4321	708	15	known	know	VERB
gs-4321	708	16	resistance	resistance	NOUN
gs-4321	708	17	trajectories	trajectory	NOUN
gs-4321	708	18	across	across	ADP
gs-4321	708	19	cancer	cancer	NOUN
gs-4321	708	20	types	type	NOUN
gs-4321	708	21	indicate	indicate	VERB
gs-4321	708	22	that	that	SCONJ
gs-4321	708	23	malignant	malignant	ADJ
gs-4321	708	24	cells	cell	NOUN
gs-4321	708	25	undergo	undergo	VERB
gs-4321	708	26	coordinated	coordinated	ADJ
gs-4321	708	27	transcriptional	transcriptional	ADJ
gs-4321	708	28	and	and	CCONJ
gs-4321	708	29	epigenetic	epigenetic	ADJ
gs-4321	708	30	rewiring	rewiring	NOUN
gs-4321	708	31	shortly	shortly	ADV
gs-4321	708	32	after	after	ADP
gs-4321	708	33	treatment	treatment	NOUN
gs-4321	708	34	exposure	exposure	NOUN
gs-4321	708	35	.	.	PUNCT
gs-4321	709	1	these	these	DET
gs-4321	709	2	early	early	ADJ
gs-4321	709	3	-	-	PUNCT
gs-4321	709	4	phase	phase	NOUN
gs-4321	709	5	adaptive	adaptive	ADJ
gs-4321	709	6	signatures	signature	NOUN
gs-4321	709	7	represent	represent	VERB
gs-4321	709	8	windows	window	NOUN
gs-4321	709	9	of	of	ADP
gs-4321	709	10	vulnerability	vulnerability	NOUN
gs-4321	709	11	in	in	ADP
gs-4321	709	12	which	which	PRON
gs-4321	709	13	therapeutic	therapeutic	ADJ
gs-4321	709	14	intervention	intervention	NOUN
gs-4321	709	15	may	may	AUX
gs-4321	709	16	be	be	AUX
gs-4321	709	17	most	most	ADV
gs-4321	709	18	impactful	impactful	ADJ
gs-4321	709	19	,	,	PUNCT
gs-4321	709	20	suggesting	suggest	VERB
gs-4321	709	21	new	new	ADJ
gs-4321	709	22	opportunities	opportunity	NOUN
gs-4321	709	23	for	for	ADP
gs-4321	709	24	targeting	target	VERB
gs-4321	709	25	cells	cell	NOUN
gs-4321	709	26	before	before	SCONJ
gs-4321	709	27	they	they	PRON
gs-4321	709	28	stabilize	stabilize	VERB
gs-4321	709	29	into	into	ADP
gs-4321	709	30	resistant	resistant	ADJ
gs-4321	709	31	phenotypes	phenotype	NOUN
gs-4321	709	32	.	.	PUNCT
gs-4321	710	1	the	the	DET
gs-4321	710	2	multi	multi	ADJ
gs-4321	710	3	-	-	ADJ
gs-4321	710	4	omics	omics	ADJ
gs-4321	710	5	integration	integration	NOUN
gs-4321	710	6	performed	perform	VERB
gs-4321	710	7	in	in	ADP
gs-4321	710	8	this	this	DET
gs-4321	710	9	work	work	NOUN
gs-4321	710	10	illustrates	illustrate	VERB
gs-4321	710	11	the	the	DET
gs-4321	710	12	value	value	NOUN
gs-4321	710	13	of	of	ADP
gs-4321	710	14	combining	combine	VERB
gs-4321	710	15	transcriptomic	transcriptomic	ADJ
gs-4321	710	16	,	,	PUNCT
gs-4321	710	17	epigenomic	epigenomic	ADJ
gs-4321	710	18	,	,	PUNCT
gs-4321	710	19	proteomic	proteomic	NOUN
gs-4321	710	20	,	,	PUNCT
gs-4321	710	21	metabolic	metabolic	NOUN
gs-4321	710	22	,	,	PUNCT
gs-4321	710	23	and	and	CCONJ
gs-4321	710	24	spatial	spatial	ADJ
gs-4321	710	25	modalities	modality	NOUN
gs-4321	710	26	to	to	PART
gs-4321	710	27	decode	decode	VERB
gs-4321	710	28	the	the	DET
gs-4321	710	29	multi	multi	ADJ
gs-4321	710	30	-	-	ADJ
gs-4321	710	31	dimensional	dimensional	ADJ
gs-4321	710	32	logic	logic	NOUN
gs-4321	710	33	of	of	ADP
gs-4321	710	34	cancer	cancer	NOUN
gs-4321	710	35	adaptation	adaptation	NOUN
gs-4321	710	36	.	.	PUNCT
gs-4321	711	1	single	single	ADJ
gs-4321	711	2	-	-	PUNCT
gs-4321	711	3	cell	cell	NOUN
gs-4321	711	4	proteogenomics	proteogenomic	NOUN
gs-4321	711	5	reveals	reveal	VERB
gs-4321	711	6	posttranscriptional	posttranscriptional	ADJ
gs-4321	711	7	regulatory	regulatory	ADJ
gs-4321	711	8	features	feature	NOUN
gs-4321	711	9	,	,	PUNCT
gs-4321	711	10	while	while	SCONJ
gs-4321	711	11	atac	atac	ADJ
gs-4321	711	12	–	–	PUNCT
gs-4321	711	13	rna	rna	NOUN
gs-4321	711	14	integration	integration	NOUN
gs-4321	711	15	highlights	highlight	NOUN
gs-4321	711	16	chromatin	chromatin	NOUN
gs-4321	711	17	priming	prime	VERB
gs-4321	711	18	events	event	NOUN
gs-4321	711	19	that	that	PRON
gs-4321	711	20	precede	precede	VERB
gs-4321	711	21	fate	fate	NOUN
gs-4321	711	22	decisions	decision	NOUN
gs-4321	711	23	.	.	PUNCT
gs-4321	712	1	spatial	spatial	ADJ
gs-4321	712	2	transcriptomics	transcriptomic	NOUN
gs-4321	712	3	embeds	embed	VERB
gs-4321	712	4	these	these	DET
gs-4321	712	5	regulatory	regulatory	ADJ
gs-4321	712	6	processes	process	NOUN
gs-4321	712	7	within	within	ADP
gs-4321	712	8	niche	niche	NOUN
gs-4321	712	9	architecture	architecture	NOUN
gs-4321	712	10	,	,	PUNCT
gs-4321	712	11	revealing	reveal	VERB
gs-4321	712	12	new	new	ADJ
gs-4321	712	13	ecological	ecological	ADJ
gs-4321	712	14	determinants	determinant	NOUN
gs-4321	712	15	of	of	ADP
gs-4321	712	16	state	state	NOUN
gs-4321	712	17	transitions	transition	NOUN
gs-4321	712	18	.	.	PUNCT
gs-4321	713	1	together	together	ADV
gs-4321	713	2	,	,	PUNCT
gs-4321	713	3	these	these	DET
gs-4321	713	4	multimodal	multimodal	ADJ
gs-4321	713	5	insights	insight	NOUN
gs-4321	713	6	support	support	VERB
gs-4321	713	7	the	the	DET
gs-4321	713	8	emerging	emerge	VERB
gs-4321	713	9	paradigm	paradigm	NOUN
gs-4321	713	10	that	that	PRON
gs-4321	713	11	plasticity	plasticity	NOUN
gs-4321	713	12	is	be	AUX
gs-4321	713	13	a	a	DET
gs-4321	713	14	distributed	distribute	VERB
gs-4321	713	15	systems	system	NOUN
gs-4321	713	16	-	-	PUNCT
gs-4321	713	17	level	level	NOUN
gs-4321	713	18	phenomenon	phenomenon	NOUN
gs-4321	713	19	shaped	shape	VERB
gs-4321	713	20	by	by	ADP
gs-4321	713	21	interactions	interaction	NOUN
gs-4321	713	22	across	across	ADP
gs-4321	713	23	multiple	multiple	ADJ
gs-4321	713	24	biological	biological	ADJ
gs-4321	713	25	layers	layer	NOUN
gs-4321	713	26	.	.	PUNCT
gs-4321	714	1	importantly	importantly	ADV
gs-4321	714	2	,	,	PUNCT
gs-4321	714	3	these	these	DET
gs-4321	714	4	findings	finding	NOUN
gs-4321	714	5	have	have	VERB
gs-4321	714	6	direct	direct	ADJ
gs-4321	714	7	implications	implication	NOUN
gs-4321	714	8	for	for	ADP
gs-4321	714	9	therapeutic	therapeutic	ADJ
gs-4321	714	10	innovation	innovation	NOUN
gs-4321	714	11	.	.	PUNCT
gs-4321	715	1	targeting	target	VERB
gs-4321	715	2	the	the	DET
gs-4321	715	3	molecular	molecular	ADJ
gs-4321	715	4	drivers	driver	NOUN
gs-4321	715	5	of	of	ADP
gs-4321	715	6	plasticity	plasticity	NOUN
gs-4321	715	7	—	—	PUNCT
gs-4321	715	8	whether	whether	SCONJ
gs-4321	715	9	through	through	ADP
gs-4321	715	10	inhibition	inhibition	NOUN
gs-4321	715	11	of	of	ADP
gs-4321	715	12	chromatin	chromatin	NOUN
gs-4321	715	13	remodelers	remodeler	NOUN
gs-4321	715	14	,	,	PUNCT
gs-4321	715	15	disruption	disruption	NOUN
gs-4321	715	16	of	of	ADP
gs-4321	715	17	inflammatory	inflammatory	ADJ
gs-4321	715	18	and	and	CCONJ
gs-4321	715	19	stromal	stromal	ADJ
gs-4321	715	20	signaling	signal	VERB
gs-4321	715	21	,	,	PUNCT
gs-4321	715	22	metabolic	metabolic	NOUN
gs-4321	715	23	pathway	pathway	NOUN
gs-4321	715	24	modulation	modulation	NOUN
gs-4321	715	25	,	,	PUNCT
gs-4321	715	26	or	or	CCONJ
gs-4321	715	27	blockade	blockade	NOUN
gs-4321	715	28	of	of	ADP
gs-4321	715	29	key	key	ADJ
gs-4321	715	30	transcriptional	transcriptional	ADJ
gs-4321	715	31	regulators	regulator	NOUN
gs-4321	715	32	—	—	PUNCT
gs-4321	715	33	offers	offer	VERB
gs-4321	715	34	a	a	DET
gs-4321	715	35	promising	promising	ADJ
gs-4321	715	36	avenue	avenue	NOUN
gs-4321	715	37	for	for	ADP
gs-4321	715	38	preventing	prevent	VERB
gs-4321	715	39	georgian	georgian	NOUN
gs-4321	715	40	scientists/	scientists/	NUM
gs-4321	715	41	.	.	PUNCT
gs-4321	716	1	7	7	NUM
gs-4321	716	2	n	n	DET
gs-4321	716	3	4	4	NUM
gs-4321	716	4	,	,	PUNCT
gs-4321	716	5	2025	2025	NUM
gs-4321	716	6	377	377	NUM
gs-4321	716	7	adaptive	adaptive	ADJ
gs-4321	716	8	reprogramming	reprogramme	VERB
gs-4321	716	9	and	and	CCONJ
gs-4321	716	10	improving	improve	VERB
gs-4321	716	11	treatment	treatment	NOUN
gs-4321	716	12	durability	durability	NOUN
gs-4321	716	13	.	.	PUNCT
gs-4321	717	1	strategies	strategy	NOUN
gs-4321	717	2	that	that	PRON
gs-4321	717	3	disrupt	disrupt	VERB
gs-4321	717	4	nichederived	nichederived	ADJ
gs-4321	717	5	support	support	NOUN
gs-4321	717	6	,	,	PUNCT
gs-4321	717	7	interfere	interfere	VERB
gs-4321	717	8	with	with	ADP
gs-4321	717	9	ligand	ligand	ADJ
gs-4321	717	10	–	–	PUNCT
gs-4321	717	11	receptor	receptor	NOUN
gs-4321	717	12	communication	communication	NOUN
gs-4321	717	13	hubs	hub	NOUN
gs-4321	717	14	,	,	PUNCT
gs-4321	717	15	or	or	CCONJ
gs-4321	717	16	target	target	VERB
gs-4321	717	17	the	the	DET
gs-4321	717	18	unique	unique	ADJ
gs-4321	717	19	vulnerabilities	vulnerability	NOUN
gs-4321	717	20	of	of	ADP
gs-4321	717	21	intermediate	intermediate	ADJ
gs-4321	717	22	states	state	NOUN
gs-4321	717	23	may	may	AUX
gs-4321	717	24	prove	prove	VERB
gs-4321	717	25	especially	especially	ADV
gs-4321	717	26	effective	effective	ADJ
gs-4321	717	27	.	.	PUNCT
gs-4321	718	1	furthermore	furthermore	ADV
gs-4321	718	2	,	,	PUNCT
gs-4321	718	3	predictive	predictive	ADJ
gs-4321	718	4	machine	machine	NOUN
gs-4321	718	5	-	-	PUNCT
gs-4321	718	6	learning	learn	VERB
gs-4321	718	7	models	model	NOUN
gs-4321	718	8	of	of	ADP
gs-4321	718	9	trajectory	trajectory	NOUN
gs-4321	718	10	progression	progression	NOUN
gs-4321	718	11	may	may	AUX
gs-4321	718	12	enable	enable	VERB
gs-4321	718	13	earlier	early	ADJ
gs-4321	718	14	identification	identification	NOUN
gs-4321	718	15	of	of	ADP
gs-4321	718	16	patients	patient	NOUN
gs-4321	718	17	at	at	ADP
gs-4321	718	18	risk	risk	NOUN
gs-4321	718	19	for	for	ADP
gs-4321	718	20	developing	develop	VERB
gs-4321	718	21	resistance	resistance	NOUN
gs-4321	718	22	,	,	PUNCT
gs-4321	718	23	thereby	thereby	ADV
gs-4321	718	24	guiding	guide	VERB
gs-4321	718	25	more	more	ADV
gs-4321	718	26	personalized	personalized	ADJ
gs-4321	718	27	therapeutic	therapeutic	ADJ
gs-4321	718	28	interventions	intervention	NOUN
gs-4321	718	29	.	.	PUNCT
gs-4321	719	1	despite	despite	SCONJ
gs-4321	719	2	its	its	PRON
gs-4321	719	3	strengths	strength	NOUN
gs-4321	719	4	,	,	PUNCT
gs-4321	719	5	this	this	DET
gs-4321	719	6	study	study	NOUN
gs-4321	719	7	also	also	ADV
gs-4321	719	8	highlights	highlight	VERB
gs-4321	719	9	the	the	DET
gs-4321	719	10	need	need	NOUN
gs-4321	719	11	for	for	ADP
gs-4321	719	12	deeper	deep	ADJ
gs-4321	719	13	integration	integration	NOUN
gs-4321	719	14	of	of	ADP
gs-4321	719	15	single	single	ADJ
gs-4321	719	16	-	-	PUNCT
gs-4321	719	17	cell	cell	NOUN
gs-4321	719	18	dna	dna	NOUN
gs-4321	719	19	sequencing	sequencing	NOUN
gs-4321	719	20	,	,	PUNCT
gs-4321	719	21	longitudinal	longitudinal	ADJ
gs-4321	719	22	sampling	sampling	NOUN
gs-4321	719	23	,	,	PUNCT
gs-4321	719	24	and	and	CCONJ
gs-4321	719	25	proteomic	proteomic	ADJ
gs-4321	719	26	quantification	quantification	NOUN
gs-4321	719	27	to	to	PART
gs-4321	719	28	fully	fully	ADV
gs-4321	719	29	resolve	resolve	VERB
gs-4321	719	30	the	the	DET
gs-4321	719	31	interplay	interplay	NOUN
gs-4321	719	32	between	between	ADP
gs-4321	719	33	genetic	genetic	ADJ
gs-4321	719	34	evolution	evolution	NOUN
gs-4321	719	35	and	and	CCONJ
gs-4321	719	36	phenotypic	phenotypic	ADJ
gs-4321	719	37	adaptability	adaptability	NOUN
gs-4321	719	38	.	.	PUNCT
gs-4321	720	1	nonetheless	nonetheless	ADV
gs-4321	720	2	,	,	PUNCT
gs-4321	720	3	the	the	DET
gs-4321	720	4	multiomics	multiomics	NOUN
gs-4321	720	5	–	–	PUNCT
gs-4321	720	6	driven	drive	VERB
gs-4321	720	7	approach	approach	NOUN
gs-4321	720	8	presented	present	VERB
gs-4321	720	9	here	here	ADV
gs-4321	720	10	establishes	establish	VERB
gs-4321	720	11	a	a	DET
gs-4321	720	12	robust	robust	ADJ
gs-4321	720	13	conceptual	conceptual	ADJ
gs-4321	720	14	and	and	CCONJ
gs-4321	720	15	computational	computational	ADJ
gs-4321	720	16	foundation	foundation	NOUN
gs-4321	720	17	for	for	ADP
gs-4321	720	18	future	future	ADJ
gs-4321	720	19	analyses	analysis	NOUN
gs-4321	720	20	aimed	aim	VERB
gs-4321	720	21	at	at	ADP
gs-4321	720	22	unraveling	unravel	VERB
gs-4321	720	23	the	the	DET
gs-4321	720	24	complexity	complexity	NOUN
gs-4321	720	25	of	of	ADP
gs-4321	720	26	tumor	tumor	NOUN
gs-4321	720	27	ecosystems	ecosystem	NOUN
gs-4321	720	28	.	.	PUNCT
gs-4321	721	1	in	in	ADP
gs-4321	721	2	conclusion	conclusion	NOUN
gs-4321	721	3	,	,	PUNCT
gs-4321	721	4	the	the	DET
gs-4321	721	5	integrative	integrative	ADJ
gs-4321	721	6	bioinformatic	bioinformatic	ADJ
gs-4321	721	7	model	model	NOUN
gs-4321	721	8	presented	present	VERB
gs-4321	721	9	in	in	ADP
gs-4321	721	10	this	this	DET
gs-4321	721	11	work	work	NOUN
gs-4321	721	12	advances	advance	VERB
gs-4321	721	13	a	a	DET
gs-4321	721	14	unified	unified	ADJ
gs-4321	721	15	understanding	understanding	NOUN
gs-4321	721	16	of	of	ADP
gs-4321	721	17	cancer	cancer	NOUN
gs-4321	721	18	plasticity	plasticity	NOUN
gs-4321	721	19	as	as	ADP
gs-4321	721	20	an	an	DET
gs-4321	721	21	emergent	emergent	ADJ
gs-4321	721	22	property	property	NOUN
gs-4321	721	23	shaped	shape	VERB
gs-4321	721	24	by	by	ADP
gs-4321	721	25	molecular	molecular	ADJ
gs-4321	721	26	,	,	PUNCT
gs-4321	721	27	epigenetic	epigenetic	ADJ
gs-4321	721	28	,	,	PUNCT
gs-4321	721	29	metabolic	metabolic	NOUN
gs-4321	721	30	,	,	PUNCT
gs-4321	721	31	ecological	ecological	ADJ
gs-4321	721	32	,	,	PUNCT
gs-4321	721	33	and	and	CCONJ
gs-4321	721	34	spatial	spatial	ADJ
gs-4321	721	35	determinants	determinant	NOUN
gs-4321	721	36	.	.	PUNCT
gs-4321	722	1	by	by	ADP
gs-4321	722	2	illuminating	illuminate	VERB
gs-4321	722	3	the	the	DET
gs-4321	722	4	regulatory	regulatory	ADJ
gs-4321	722	5	logic	logic	NOUN
gs-4321	722	6	and	and	CCONJ
gs-4321	722	7	communication	communication	NOUN
gs-4321	722	8	networks	network	NOUN
gs-4321	722	9	that	that	PRON
gs-4321	722	10	drive	drive	VERB
gs-4321	722	11	malignant	malignant	ADJ
gs-4321	722	12	adaptability	adaptability	NOUN
gs-4321	722	13	,	,	PUNCT
gs-4321	722	14	this	this	DET
gs-4321	722	15	study	study	NOUN
gs-4321	722	16	lays	lay	VERB
gs-4321	722	17	the	the	DET
gs-4321	722	18	groundwork	groundwork	NOUN
gs-4321	722	19	for	for	ADP
gs-4321	722	20	a	a	DET
gs-4321	722	21	new	new	ADJ
gs-4321	722	22	generation	generation	NOUN
gs-4321	722	23	of	of	ADP
gs-4321	722	24	precision	precision	NOUN
gs-4321	722	25	oncology	oncology	NOUN
gs-4321	722	26	strategies	strategy	NOUN
gs-4321	722	27	that	that	PRON
gs-4321	722	28	target	target	VERB
gs-4321	722	29	the	the	DET
gs-4321	722	30	dynamic	dynamic	ADJ
gs-4321	722	31	,	,	PUNCT
gs-4321	722	32	evolving	evolve	VERB
gs-4321	722	33	nature	nature	NOUN
gs-4321	722	34	of	of	ADP
gs-4321	722	35	cancer	cancer	NOUN
gs-4321	722	36	rather	rather	ADV
gs-4321	722	37	than	than	ADP
gs-4321	722	38	its	its	PRON
gs-4321	722	39	static	static	ADJ
gs-4321	722	40	features	feature	NOUN
gs-4321	722	41	.	.	PUNCT
gs-4321	723	1	such	such	DET
gs-4321	723	2	an	an	DET
gs-4321	723	3	approach	approach	NOUN
gs-4321	723	4	has	have	VERB
gs-4321	723	5	the	the	DET
gs-4321	723	6	potential	potential	NOUN
gs-4321	723	7	to	to	PART
gs-4321	723	8	transform	transform	VERB
gs-4321	723	9	clinical	clinical	ADJ
gs-4321	723	10	outcomes	outcome	NOUN
gs-4321	723	11	by	by	ADP
gs-4321	723	12	preempting	preempt	VERB
gs-4321	723	13	resistance	resistance	NOUN
gs-4321	723	14	,	,	PUNCT
gs-4321	723	15	reducing	reduce	VERB
gs-4321	723	16	recurrence	recurrence	NOUN
gs-4321	723	17	,	,	PUNCT
gs-4321	723	18	and	and	CCONJ
gs-4321	723	19	ultimately	ultimately	ADV
gs-4321	723	20	improving	improve	VERB
gs-4321	723	21	the	the	DET
gs-4321	723	22	long	long	ADJ
gs-4321	723	23	-	-	PUNCT
gs-4321	723	24	term	term	NOUN
gs-4321	723	25	management	management	NOUN
gs-4321	723	26	of	of	ADP
gs-4321	723	27	malignant	malignant	ADJ
gs-4321	723	28	diseases	disease	NOUN
gs-4321	723	29	.	.	PUNCT
gs-4321	724	1	recommendations	recommendation	NOUN
gs-4321	724	2	future	future	ADJ
gs-4321	724	3	research	research	NOUN
gs-4321	724	4	should	should	AUX
gs-4321	724	5	prioritize	prioritize	VERB
gs-4321	724	6	the	the	DET
gs-4321	724	7	development	development	NOUN
gs-4321	724	8	of	of	ADP
gs-4321	724	9	integrated	integrate	VERB
gs-4321	724	10	multi	multi	ADJ
gs-4321	724	11	-	-	ADJ
gs-4321	724	12	omics	omics	ADJ
gs-4321	724	13	platforms	platform	NOUN
gs-4321	724	14	that	that	PRON
gs-4321	724	15	combine	combine	VERB
gs-4321	724	16	transcriptomic	transcriptomic	ADJ
gs-4321	724	17	,	,	PUNCT
gs-4321	724	18	epigenomic	epigenomic	ADJ
gs-4321	724	19	,	,	PUNCT
gs-4321	724	20	proteomic	proteomic	ADJ
gs-4321	724	21	,	,	PUNCT
gs-4321	724	22	metabolomic	metabolomic	ADJ
gs-4321	724	23	,	,	PUNCT
gs-4321	724	24	and	and	CCONJ
gs-4321	724	25	spatial	spatial	ADJ
gs-4321	724	26	analyses	analysis	NOUN
gs-4321	724	27	within	within	ADP
gs-4321	724	28	the	the	DET
gs-4321	724	29	same	same	ADJ
gs-4321	724	30	biological	biological	ADJ
gs-4321	724	31	samples	sample	NOUN
gs-4321	724	32	to	to	PART
gs-4321	724	33	capture	capture	VERB
gs-4321	724	34	the	the	DET
gs-4321	724	35	full	full	ADJ
gs-4321	724	36	complexity	complexity	NOUN
gs-4321	724	37	of	of	ADP
gs-4321	724	38	tumor	tumor	NOUN
gs-4321	724	39	plasticity	plasticity	NOUN
gs-4321	724	40	.	.	PUNCT
gs-4321	725	1	coordinated	coordinate	VERB
gs-4321	725	2	collection	collection	NOUN
gs-4321	725	3	of	of	ADP
gs-4321	725	4	multimodal	multimodal	ADJ
gs-4321	725	5	single	single	ADJ
gs-4321	725	6	-	-	PUNCT
gs-4321	725	7	cell	cell	NOUN
gs-4321	725	8	data	datum	NOUN
gs-4321	725	9	will	will	AUX
gs-4321	725	10	provide	provide	VERB
gs-4321	725	11	a	a	DET
gs-4321	725	12	more	more	ADV
gs-4321	725	13	complete	complete	ADJ
gs-4321	725	14	representation	representation	NOUN
gs-4321	725	15	of	of	ADP
gs-4321	725	16	regulatory	regulatory	ADJ
gs-4321	725	17	architecture	architecture	NOUN
gs-4321	725	18	,	,	PUNCT
gs-4321	725	19	reveal	reveal	VERB
gs-4321	725	20	earlier	early	ADJ
gs-4321	725	21	markers	marker	NOUN
gs-4321	725	22	of	of	ADP
gs-4321	725	23	adaptive	adaptive	ADJ
gs-4321	725	24	transitions	transition	NOUN
gs-4321	725	25	,	,	PUNCT
gs-4321	725	26	and	and	CCONJ
gs-4321	725	27	enable	enable	VERB
gs-4321	725	28	the	the	DET
gs-4321	725	29	identification	identification	NOUN
gs-4321	725	30	of	of	ADP
gs-4321	725	31	molecular	molecular	ADJ
gs-4321	725	32	nodes	node	NOUN
gs-4321	725	33	that	that	PRON
gs-4321	725	34	consistently	consistently	ADV
gs-4321	725	35	govern	govern	VERB
gs-4321	725	36	state	state	NOUN
gs-4321	725	37	interconversion	interconversion	NOUN
gs-4321	725	38	across	across	ADP
gs-4321	725	39	diverse	diverse	ADJ
gs-4321	725	40	tumor	tumor	NOUN
gs-4321	725	41	contexts	contexts	NOUN
gs-4321	725	42	.	.	PUNCT
gs-4321	726	1	advances	advance	NOUN
gs-4321	726	2	in	in	ADP
gs-4321	726	3	single	single	ADJ
gs-4321	726	4	-	-	PUNCT
gs-4321	726	5	cell	cell	NOUN
gs-4321	726	6	proteomics	proteomic	NOUN
gs-4321	726	7	,	,	PUNCT
gs-4321	726	8	spatial	spatial	ADJ
gs-4321	726	9	sequencing	sequencing	NOUN
gs-4321	726	10	,	,	PUNCT
gs-4321	726	11	and	and	CCONJ
gs-4321	726	12	lineagetracing	lineagetrace	VERB
gs-4321	726	13	technologies	technology	NOUN
gs-4321	726	14	should	should	AUX
gs-4321	726	15	be	be	AUX
gs-4321	726	16	leveraged	leverage	VERB
gs-4321	726	17	to	to	PART
gs-4321	726	18	validate	validate	VERB
gs-4321	726	19	transcription	transcription	NOUN
gs-4321	726	20	-	-	PUNCT
gs-4321	726	21	based	base	VERB
gs-4321	726	22	inferences	inference	NOUN
gs-4321	726	23	and	and	CCONJ
gs-4321	726	24	establish	establish	VERB
gs-4321	726	25	causal	causal	ADJ
gs-4321	726	26	relationships	relationship	NOUN
gs-4321	726	27	between	between	ADP
gs-4321	726	28	regulatory	regulatory	ADJ
gs-4321	726	29	events	event	NOUN
gs-4321	726	30	,	,	PUNCT
gs-4321	726	31	microenvironmental	microenvironmental	ADJ
gs-4321	726	32	influences	influence	NOUN
gs-4321	726	33	,	,	PUNCT
gs-4321	726	34	and	and	CCONJ
gs-4321	726	35	functional	functional	ADJ
gs-4321	726	36	phenotypes	phenotype	NOUN
gs-4321	726	37	.	.	PUNCT
gs-4321	727	1	there	there	PRON
gs-4321	727	2	is	be	VERB
gs-4321	727	3	a	a	DET
gs-4321	727	4	growing	grow	VERB
gs-4321	727	5	need	need	NOUN
gs-4321	727	6	for	for	ADP
gs-4321	727	7	longitudinal	longitudinal	ADJ
gs-4321	727	8	and	and	CCONJ
gs-4321	727	9	perturbation	perturbation	NOUN
gs-4321	727	10	-	-	PUNCT
gs-4321	727	11	based	base	VERB
gs-4321	727	12	single	single	ADJ
gs-4321	727	13	-	-	PUNCT
gs-4321	727	14	cell	cell	NOUN
gs-4321	727	15	studies	study	NOUN
gs-4321	727	16	that	that	PRON
gs-4321	727	17	track	track	VERB
gs-4321	727	18	malignant	malignant	ADJ
gs-4321	727	19	populations	population	NOUN
gs-4321	727	20	before	before	ADV
gs-4321	727	21	,	,	PUNCT
gs-4321	727	22	during	during	ADP
gs-4321	727	23	,	,	PUNCT
gs-4321	727	24	and	and	CCONJ
gs-4321	727	25	after	after	ADP
gs-4321	727	26	therapy	therapy	NOUN
gs-4321	727	27	.	.	PUNCT
gs-4321	728	1	such	such	ADJ
gs-4321	728	2	time	time	NOUN
gs-4321	728	3	-	-	PUNCT
gs-4321	728	4	resolved	resolve	VERB
gs-4321	728	5	datasets	dataset	NOUN
gs-4321	728	6	will	will	AUX
gs-4321	728	7	allow	allow	VERB
gs-4321	728	8	investigators	investigator	NOUN
gs-4321	728	9	to	to	PART
gs-4321	728	10	map	map	VERB
gs-4321	728	11	the	the	DET
gs-4321	728	12	earliest	early	ADJ
gs-4321	728	13	adaptive	adaptive	ADJ
gs-4321	728	14	changes	change	NOUN
gs-4321	728	15	that	that	PRON
gs-4321	728	16	precede	precede	VERB
gs-4321	728	17	resistance	resistance	NOUN
gs-4321	728	18	,	,	PUNCT
gs-4321	728	19	predict	predict	VERB
gs-4321	728	20	potential	potential	ADJ
gs-4321	728	21	trajectories	trajectory	NOUN
gs-4321	728	22	of	of	ADP
gs-4321	728	23	relapse	relapse	NOUN
gs-4321	728	24	,	,	PUNCT
gs-4321	728	25	and	and	CCONJ
gs-4321	728	26	identify	identify	VERB
gs-4321	728	27	transient	transient	ADJ
gs-4321	728	28	intermediate	intermediate	ADJ
gs-4321	728	29	states	state	NOUN
gs-4321	728	30	that	that	PRON
gs-4321	728	31	may	may	AUX
gs-4321	728	32	serve	serve	VERB
gs-4321	728	33	as	as	ADP
gs-4321	728	34	optimal	optimal	ADJ
gs-4321	728	35	therapeutic	therapeutic	ADJ
gs-4321	728	36	intervention	intervention	NOUN
gs-4321	728	37	points	point	NOUN
gs-4321	728	38	.	.	PUNCT
gs-4321	729	1	incorporating	incorporate	VERB
gs-4321	729	2	in	in	ADP
gs-4321	729	3	vitro	vitro	X
gs-4321	729	4	drug	drug	NOUN
gs-4321	729	5	perturbation	perturbation	NOUN
gs-4321	729	6	models	model	NOUN
gs-4321	729	7	,	,	PUNCT
gs-4321	729	8	organoid	organoid	NOUN
gs-4321	729	9	systems	system	NOUN
gs-4321	729	10	,	,	PUNCT
gs-4321	729	11	and	and	CCONJ
gs-4321	729	12	in	in	ADP
gs-4321	729	13	vivo	vivo	ADJ
gs-4321	729	14	lineage	lineage	NOUN
gs-4321	729	15	-	-	PUNCT
gs-4321	729	16	tracking	tracking	NOUN
gs-4321	729	17	approaches	approach	NOUN
gs-4321	729	18	can	can	AUX
gs-4321	729	19	help	help	AUX
gs-4321	729	20	clarify	clarify	VERB
gs-4321	729	21	whether	whether	SCONJ
gs-4321	729	22	adaptive	adaptive	ADJ
gs-4321	729	23	phenotypes	phenotype	NOUN
gs-4321	729	24	emerge	emerge	VERB
gs-4321	729	25	from	from	ADP
gs-4321	729	26	preexisting	preexist	VERB
gs-4321	729	27	cellular	cellular	ADJ
gs-4321	729	28	states	state	NOUN
gs-4321	729	29	or	or	CCONJ
gs-4321	729	30	are	be	AUX
gs-4321	729	31	induced	induce	VERB
gs-4321	729	32	de	de	X
gs-4321	729	33	novo	novo	NOUN
gs-4321	729	34	by	by	ADP
gs-4321	729	35	therapeutic	therapeutic	ADJ
gs-4321	729	36	pressure	pressure	NOUN
gs-4321	729	37	.	.	PUNCT
gs-4321	730	1	georgian	georgian	NOUN
gs-4321	730	2	scientists/	scientists/	NUM
gs-4321	730	3	.	.	PUNCT
gs-4321	731	1	7	7	NUM
gs-4321	731	2	n	n	DET
gs-4321	731	3	4	4	NUM
gs-4321	731	4	,	,	PUNCT
gs-4321	731	5	2025	2025	NUM
gs-4321	731	6	378	378	NUM
gs-4321	731	7	therapeutic	therapeutic	ADJ
gs-4321	731	8	development	development	NOUN
gs-4321	731	9	should	should	AUX
gs-4321	731	10	increasingly	increasingly	ADV
gs-4321	731	11	focus	focus	VERB
gs-4321	731	12	on	on	ADP
gs-4321	731	13	targeting	target	VERB
gs-4321	731	14	the	the	DET
gs-4321	731	15	molecular	molecular	ADJ
gs-4321	731	16	and	and	CCONJ
gs-4321	731	17	ecological	ecological	ADJ
gs-4321	731	18	determinants	determinant	NOUN
gs-4321	731	19	of	of	ADP
gs-4321	731	20	plasticity	plasticity	NOUN
gs-4321	731	21	rather	rather	ADV
gs-4321	731	22	than	than	ADP
gs-4321	731	23	solely	solely	ADV
gs-4321	731	24	eliminating	eliminate	VERB
gs-4321	731	25	static	static	ADJ
gs-4321	731	26	cell	cell	NOUN
gs-4321	731	27	states	state	NOUN
gs-4321	731	28	.	.	PUNCT
gs-4321	732	1	strategies	strategy	NOUN
gs-4321	732	2	directed	direct	VERB
gs-4321	732	3	at	at	ADP
gs-4321	732	4	chromatin	chromatin	NOUN
gs-4321	732	5	regulators	regulator	NOUN
gs-4321	732	6	,	,	PUNCT
gs-4321	732	7	transcription	transcription	NOUN
gs-4321	732	8	factor	factor	NOUN
gs-4321	732	9	modules	module	NOUN
gs-4321	732	10	,	,	PUNCT
gs-4321	732	11	and	and	CCONJ
gs-4321	732	12	metabolic	metabolic	NOUN
gs-4321	732	13	dependencies	dependency	NOUN
gs-4321	732	14	associated	associate	VERB
gs-4321	732	15	with	with	ADP
gs-4321	732	16	intermediate	intermediate	ADJ
gs-4321	732	17	and	and	CCONJ
gs-4321	732	18	stem	stem	NOUN
gs-4321	732	19	-	-	PUNCT
gs-4321	732	20	like	like	ADJ
gs-4321	732	21	phenotypes	phenotype	NOUN
gs-4321	732	22	represent	represent	VERB
gs-4321	732	23	promising	promise	VERB
gs-4321	732	24	approaches	approach	NOUN
gs-4321	732	25	to	to	PART
gs-4321	732	26	limit	limit	VERB
gs-4321	732	27	adaptive	adaptive	ADJ
gs-4321	732	28	reprogramming	reprogramming	NOUN
gs-4321	732	29	.	.	PUNCT
gs-4321	733	1	equally	equally	ADV
gs-4321	733	2	important	important	ADJ
gs-4321	733	3	is	be	AUX
gs-4321	733	4	the	the	DET
gs-4321	733	5	targeting	targeting	NOUN
gs-4321	733	6	of	of	ADP
gs-4321	733	7	microenvironment	microenvironment	NOUN
gs-4321	733	8	-	-	PUNCT
gs-4321	733	9	derived	derive	VERB
gs-4321	733	10	signaling	signal	VERB
gs-4321	733	11	networks	network	NOUN
gs-4321	733	12	,	,	PUNCT
gs-4321	733	13	particularly	particularly	ADV
gs-4321	733	14	il-6	il-6	NUM
gs-4321	733	15	/	/	SYM
gs-4321	733	16	stat3	stat3	PROPN
gs-4321	733	17	,	,	PUNCT
gs-4321	733	18	tgf	tgf	PROPN
gs-4321	733	19	,	,	PUNCT
gs-4321	733	20	cxcl12	cxcl12	ADJ
gs-4321	733	21	/	/	SYM
gs-4321	733	22	cxcr4	cxcr4	PROPN
gs-4321	733	23	,	,	PUNCT
gs-4321	733	24	wnt	wnt	PROPN
gs-4321	733	25	/	/	SYM
gs-4321	733	26	fzd	fzd	PROPN
gs-4321	733	27	,	,	PUNCT
gs-4321	733	28	and	and	CCONJ
gs-4321	733	29	hgf	hgf	PROPN
gs-4321	733	30	/	/	SYM
gs-4321	733	31	met	meet	VERB
gs-4321	733	32	pathways	pathway	NOUN
gs-4321	733	33	,	,	PUNCT
gs-4321	733	34	which	which	PRON
gs-4321	733	35	collectively	collectively	ADV
gs-4321	733	36	shape	shape	VERB
gs-4321	733	37	stemness	stemness	ADJ
gs-4321	733	38	induction	induction	NOUN
gs-4321	733	39	,	,	PUNCT
gs-4321	733	40	immune	immune	ADJ
gs-4321	733	41	evasion	evasion	NOUN
gs-4321	733	42	,	,	PUNCT
gs-4321	733	43	and	and	CCONJ
gs-4321	733	44	metastatic	metastatic	ADJ
gs-4321	733	45	progression	progression	NOUN
gs-4321	733	46	.	.	PUNCT
gs-4321	734	1	therapies	therapy	NOUN
gs-4321	734	2	that	that	PRON
gs-4321	734	3	disrupt	disrupt	VERB
gs-4321	734	4	communication	communication	NOUN
gs-4321	734	5	between	between	ADP
gs-4321	734	6	malignant	malignant	ADJ
gs-4321	734	7	cells	cell	NOUN
gs-4321	734	8	and	and	CCONJ
gs-4321	734	9	their	their	PRON
gs-4321	734	10	supporting	support	VERB
gs-4321	734	11	stromal	stromal	ADJ
gs-4321	734	12	or	or	CCONJ
gs-4321	734	13	immune	immune	ADJ
gs-4321	734	14	niches	niche	NOUN
gs-4321	734	15	may	may	AUX
gs-4321	734	16	prove	prove	VERB
gs-4321	734	17	especially	especially	ADV
gs-4321	734	18	effective	effective	ADJ
gs-4321	734	19	in	in	ADP
gs-4321	734	20	preventing	prevent	VERB
gs-4321	734	21	the	the	DET
gs-4321	734	22	stabilization	stabilization	NOUN
gs-4321	734	23	of	of	ADP
gs-4321	734	24	therapy	therapy	NOUN
gs-4321	734	25	-	-	PUNCT
gs-4321	734	26	resistant	resistant	ADJ
gs-4321	734	27	states	state	NOUN
gs-4321	734	28	.	.	PUNCT
gs-4321	735	1	it	it	PRON
gs-4321	735	2	is	be	AUX
gs-4321	735	3	recommended	recommend	VERB
gs-4321	735	4	that	that	SCONJ
gs-4321	735	5	future	future	ADJ
gs-4321	735	6	computational	computational	ADJ
gs-4321	735	7	frameworks	framework	NOUN
gs-4321	735	8	incorporate	incorporate	VERB
gs-4321	735	9	models	model	NOUN
gs-4321	735	10	capable	capable	ADJ
gs-4321	735	11	of	of	ADP
gs-4321	735	12	unifying	unify	VERB
gs-4321	735	13	genetic	genetic	ADJ
gs-4321	735	14	,	,	PUNCT
gs-4321	735	15	transcriptional	transcriptional	ADJ
gs-4321	735	16	,	,	PUNCT
gs-4321	735	17	epigenetic	epigenetic	ADJ
gs-4321	735	18	,	,	PUNCT
gs-4321	735	19	metabolic	metabolic	NOUN
gs-4321	735	20	,	,	PUNCT
gs-4321	735	21	and	and	CCONJ
gs-4321	735	22	spatial	spatial	ADJ
gs-4321	735	23	information	information	NOUN
gs-4321	735	24	to	to	PART
gs-4321	735	25	provide	provide	VERB
gs-4321	735	26	a	a	DET
gs-4321	735	27	more	more	ADV
gs-4321	735	28	holistic	holistic	ADJ
gs-4321	735	29	understanding	understanding	NOUN
gs-4321	735	30	of	of	ADP
gs-4321	735	31	tumor	tumor	NOUN
gs-4321	735	32	ecosystem	ecosystem	NOUN
gs-4321	735	33	dynamics	dynamic	NOUN
gs-4321	735	34	.	.	PUNCT
gs-4321	736	1	machine	machine	NOUN
gs-4321	736	2	-	-	PUNCT
gs-4321	736	3	learning	learn	VERB
gs-4321	736	4	approaches	approach	NOUN
gs-4321	736	5	should	should	AUX
gs-4321	736	6	be	be	AUX
gs-4321	736	7	expanded	expand	VERB
gs-4321	736	8	to	to	PART
gs-4321	736	9	predict	predict	VERB
gs-4321	736	10	future	future	ADJ
gs-4321	736	11	cell	cell	NOUN
gs-4321	736	12	states	state	NOUN
gs-4321	736	13	,	,	PUNCT
gs-4321	736	14	identify	identify	VERB
gs-4321	736	15	high	high	ADJ
gs-4321	736	16	-	-	PUNCT
gs-4321	736	17	risk	risk	NOUN
gs-4321	736	18	subpopulations	subpopulation	NOUN
gs-4321	736	19	before	before	SCONJ
gs-4321	736	20	resistance	resistance	NOUN
gs-4321	736	21	emerges	emerge	VERB
gs-4321	736	22	,	,	PUNCT
gs-4321	736	23	and	and	CCONJ
gs-4321	736	24	simulate	simulate	VERB
gs-4321	736	25	therapeutic	therapeutic	ADJ
gs-4321	736	26	interventions	intervention	NOUN
gs-4321	736	27	under	under	ADP
gs-4321	736	28	various	various	ADJ
gs-4321	736	29	microenvironmental	microenvironmental	ADJ
gs-4321	736	30	conditions	condition	NOUN
gs-4321	736	31	.	.	PUNCT
gs-4321	737	1	such	such	ADJ
gs-4321	737	2	predictive	predictive	ADJ
gs-4321	737	3	systems	system	NOUN
gs-4321	737	4	,	,	PUNCT
gs-4321	737	5	once	once	ADV
gs-4321	737	6	validated	validate	VERB
gs-4321	737	7	in	in	ADP
gs-4321	737	8	clinical	clinical	ADJ
gs-4321	737	9	settings	setting	NOUN
gs-4321	737	10	,	,	PUNCT
gs-4321	737	11	have	have	VERB
gs-4321	737	12	the	the	DET
gs-4321	737	13	potential	potential	NOUN
gs-4321	737	14	to	to	PART
gs-4321	737	15	guide	guide	VERB
gs-4321	737	16	real	real	ADJ
gs-4321	737	17	-	-	PUNCT
gs-4321	737	18	time	time	NOUN
gs-4321	737	19	therapeutic	therapeutic	ADJ
gs-4321	737	20	decision	decision	NOUN
gs-4321	737	21	-	-	PUNCT
gs-4321	737	22	making	making	NOUN
gs-4321	737	23	and	and	CCONJ
gs-4321	737	24	inform	inform	VERB
gs-4321	737	25	personalized	personalized	ADJ
gs-4321	737	26	treatment	treatment	NOUN
gs-4321	737	27	strategies	strategy	NOUN
gs-4321	737	28	.	.	PUNCT
gs-4321	738	1	given	give	VERB
gs-4321	738	2	the	the	DET
gs-4321	738	3	strong	strong	ADJ
gs-4321	738	4	ecological	ecological	ADJ
gs-4321	738	5	basis	basis	NOUN
gs-4321	738	6	of	of	ADP
gs-4321	738	7	plasticity	plasticity	NOUN
gs-4321	738	8	,	,	PUNCT
gs-4321	738	9	research	research	NOUN
gs-4321	738	10	should	should	AUX
gs-4321	738	11	also	also	ADV
gs-4321	738	12	explore	explore	VERB
gs-4321	738	13	therapeutic	therapeutic	ADJ
gs-4321	738	14	strategies	strategy	NOUN
gs-4321	738	15	that	that	PRON
gs-4321	738	16	aim	aim	VERB
gs-4321	738	17	to	to	PART
gs-4321	738	18	modify	modify	VERB
gs-4321	738	19	the	the	DET
gs-4321	738	20	tumor	tumor	NOUN
gs-4321	738	21	microenvironment	microenvironment	NOUN
gs-4321	738	22	itself	itself	PRON
gs-4321	738	23	.	.	PUNCT
gs-4321	739	1	modulating	modulate	VERB
gs-4321	739	2	inflammatory	inflammatory	ADJ
gs-4321	739	3	cytokine	cytokine	NOUN
gs-4321	739	4	gradients	gradient	NOUN
gs-4321	739	5	,	,	PUNCT
gs-4321	739	6	reducing	reduce	VERB
gs-4321	739	7	immunosuppressive	immunosuppressive	ADJ
gs-4321	739	8	myeloid	myeloid	ADJ
gs-4321	739	9	infiltration	infiltration	NOUN
gs-4321	739	10	,	,	PUNCT
gs-4321	739	11	remodeling	remodel	VERB
gs-4321	739	12	extracellular	extracellular	ADJ
gs-4321	739	13	matrix	matrix	NOUN
gs-4321	739	14	architecture	architecture	NOUN
gs-4321	739	15	,	,	PUNCT
gs-4321	739	16	or	or	CCONJ
gs-4321	739	17	altering	alter	VERB
gs-4321	739	18	vascular	vascular	ADJ
gs-4321	739	19	niche	niche	NOUN
gs-4321	739	20	composition	composition	NOUN
gs-4321	739	21	may	may	AUX
gs-4321	739	22	reduce	reduce	VERB
gs-4321	739	23	the	the	DET
gs-4321	739	24	selective	selective	ADJ
gs-4321	739	25	pressures	pressure	NOUN
gs-4321	739	26	that	that	PRON
gs-4321	739	27	drive	drive	VERB
gs-4321	739	28	phenotypic	phenotypic	ADJ
gs-4321	739	29	adaptation	adaptation	NOUN
gs-4321	739	30	.	.	PUNCT
gs-4321	740	1	integrating	integrate	VERB
gs-4321	740	2	immunotherapy	immunotherapy	NOUN
gs-4321	740	3	with	with	ADP
gs-4321	740	4	plasticity	plasticity	NOUN
gs-4321	740	5	-	-	PUNCT
gs-4321	740	6	targeting	target	VERB
gs-4321	740	7	interventions	intervention	NOUN
gs-4321	740	8	may	may	AUX
gs-4321	740	9	also	also	ADV
gs-4321	740	10	enhance	enhance	VERB
gs-4321	740	11	treatment	treatment	NOUN
gs-4321	740	12	efficacy	efficacy	NOUN
gs-4321	740	13	,	,	PUNCT
gs-4321	740	14	especially	especially	ADV
gs-4321	740	15	in	in	ADP
gs-4321	740	16	tumors	tumor	NOUN
gs-4321	740	17	where	where	SCONJ
gs-4321	740	18	immune	immune	NOUN
gs-4321	740	19	-	-	PUNCT
gs-4321	740	20	mediated	mediate	VERB
gs-4321	740	21	stress	stress	NOUN
gs-4321	740	22	promotes	promote	VERB
gs-4321	740	23	dedifferentiation	dedifferentiation	NOUN
gs-4321	740	24	and	and	CCONJ
gs-4321	740	25	persistence	persistence	NOUN
gs-4321	740	26	.	.	PUNCT
gs-4321	741	1	finally	finally	ADV
gs-4321	741	2	,	,	PUNCT
gs-4321	741	3	translational	translational	ADJ
gs-4321	741	4	efforts	effort	NOUN
gs-4321	741	5	should	should	AUX
gs-4321	741	6	prioritize	prioritize	VERB
gs-4321	741	7	clinical	clinical	ADJ
gs-4321	741	8	trials	trial	NOUN
gs-4321	741	9	that	that	PRON
gs-4321	741	10	evaluate	evaluate	VERB
gs-4321	741	11	combination	combination	NOUN
gs-4321	741	12	therapies	therapy	NOUN
gs-4321	741	13	designed	design	VERB
gs-4321	741	14	to	to	PART
gs-4321	741	15	simultaneously	simultaneously	ADV
gs-4321	741	16	target	target	VERB
gs-4321	741	17	bulk	bulk	ADJ
gs-4321	741	18	tumor	tumor	NOUN
gs-4321	741	19	populations	population	NOUN
gs-4321	741	20	and	and	CCONJ
gs-4321	741	21	the	the	DET
gs-4321	741	22	plastic	plastic	ADJ
gs-4321	741	23	intermediate	intermediate	ADJ
gs-4321	741	24	states	state	NOUN
gs-4321	741	25	responsible	responsible	ADJ
gs-4321	741	26	for	for	ADP
gs-4321	741	27	therapeutic	therapeutic	ADJ
gs-4321	741	28	escape	escape	NOUN
gs-4321	741	29	.	.	PUNCT
gs-4321	742	1	monitoring	monitoring	NOUN
gs-4321	742	2	of	of	ADP
gs-4321	742	3	patient	patient	ADJ
gs-4321	742	4	samples	sample	NOUN
gs-4321	742	5	using	use	VERB
gs-4321	742	6	multi	multi	ADJ
gs-4321	742	7	-	-	ADJ
gs-4321	742	8	omic	omic	ADJ
gs-4321	742	9	single	single	ADJ
gs-4321	742	10	-	-	PUNCT
gs-4321	742	11	cell	cell	NOUN
gs-4321	742	12	analyses	analysis	NOUN
gs-4321	742	13	during	during	ADP
gs-4321	742	14	treatment	treatment	NOUN
gs-4321	742	15	should	should	AUX
gs-4321	742	16	become	become	VERB
gs-4321	742	17	a	a	DET
gs-4321	742	18	key	key	ADJ
gs-4321	742	19	component	component	NOUN
gs-4321	742	20	of	of	ADP
gs-4321	742	21	precision	precision	NOUN
gs-4321	742	22	oncology	oncology	NOUN
gs-4321	742	23	programs	program	NOUN
gs-4321	742	24	,	,	PUNCT
gs-4321	742	25	providing	provide	VERB
gs-4321	742	26	continuous	continuous	ADJ
gs-4321	742	27	insight	insight	NOUN
gs-4321	742	28	into	into	ADP
gs-4321	742	29	tumor	tumor	NOUN
gs-4321	742	30	evolution	evolution	NOUN
gs-4321	742	31	,	,	PUNCT
gs-4321	742	32	identifying	identify	VERB
gs-4321	742	33	the	the	DET
gs-4321	742	34	emergence	emergence	NOUN
gs-4321	742	35	of	of	ADP
gs-4321	742	36	adaptive	adaptive	ADJ
gs-4321	742	37	phenotypes	phenotype	NOUN
gs-4321	742	38	,	,	PUNCT
gs-4321	742	39	and	and	CCONJ
gs-4321	742	40	enabling	enable	VERB
gs-4321	742	41	timely	timely	ADJ
gs-4321	742	42	therapeutic	therapeutic	ADJ
gs-4321	742	43	adjustments	adjustment	NOUN
gs-4321	742	44	.	.	PUNCT
gs-4321	743	1	georgian	georgian	NOUN
gs-4321	743	2	scientists/	scientists/	NUM
gs-4321	743	3	.	.	PUNCT
gs-4321	744	1	7	7	NUM
gs-4321	744	2	n	n	DET
gs-4321	744	3	4	4	NUM
gs-4321	744	4	,	,	PUNCT
gs-4321	744	5	2025	2025	NUM
gs-4321	744	6	379	379	NUM
gs-4321	744	7	references	reference	NOUN
gs-4321	744	8	aibar	aibar	NOUN
gs-4321	744	9	,	,	PUNCT
gs-4321	744	10	s.	s.	PROPN
gs-4321	744	11	,	,	PUNCT
gs-4321	744	12	gonzález	gonzález	PROPN
gs-4321	744	13	-	-	PUNCT
gs-4321	744	14	blas	blas	PROPN
gs-4321	744	15	,	,	PUNCT
gs-4321	744	16	c.	c.	PROPN
gs-4321	744	17	b.	b.	PROPN
gs-4321	744	18	,	,	PUNCT
gs-4321	744	19	moerman	moerman	PROPN
gs-4321	744	20	,	,	PUNCT
gs-4321	744	21	t.	t.	PROPN
gs-4321	744	22	(	(	PUNCT
gs-4321	744	23	2017	2017	NUM
gs-4321	744	24	)	)	PUNCT
gs-4321	744	25	.	.	PUNCT
gs-4321	745	1	scenic	scenic	ADJ
gs-4321	745	2	:	:	PUNCT
gs-4321	745	3	single	single	ADJ
gs-4321	745	4	-	-	PUNCT
gs-4321	745	5	cell	cell	NOUN
gs-4321	745	6	regulatory	regulatory	ADJ
gs-4321	745	7	network	network	NOUN
gs-4321	745	8	inference	inference	NOUN
gs-4321	745	9	and	and	CCONJ
gs-4321	745	10	clustering	clustering	NOUN
gs-4321	745	11	.	.	PUNCT
gs-4321	746	1	nature	nature	NOUN
gs-4321	746	2	methods	method	NOUN
gs-4321	746	3	,	,	PUNCT
gs-4321	746	4	14(11	14(11	NUM
gs-4321	746	5	)	)	PUNCT
gs-4321	746	6	,	,	PUNCT
gs-4321	746	7	1083–1086	1083–1086	NUM
gs-4321	746	8	.	.	PUNCT
gs-4321	747	1	argelaguet	argelaguet	PROPN
gs-4321	747	2	,	,	PUNCT
gs-4321	747	3	r.	r.	PROPN
gs-4321	747	4	,	,	PUNCT
gs-4321	747	5	arnol	arnol	ADV
gs-4321	747	6	,	,	PUNCT
gs-4321	747	7	d.	d.	PROPN
gs-4321	747	8	,	,	PUNCT
gs-4321	747	9	bredikhin	bredikhin	PROPN
gs-4321	747	10	,	,	PUNCT
gs-4321	747	11	d.	d.	PROPN
gs-4321	747	12	,	,	PUNCT
gs-4321	747	13	deloro	deloro	PROPN
gs-4321	747	14	,	,	PUNCT
gs-4321	747	15	y.	y.	PROPN
gs-4321	747	16	,	,	PUNCT
gs-4321	747	17	velten	velten	VERB
gs-4321	747	18	,	,	PUNCT
gs-4321	747	19	b.	b.	PROPN
gs-4321	747	20	,	,	PUNCT
gs-4321	747	21	marioni	marioni	NOUN
gs-4321	747	22	,	,	PUNCT
gs-4321	747	23	j.	j.	PROPN
gs-4321	747	24	c.	c.	PROPN
gs-4321	747	25	,	,	PUNCT
gs-4321	747	26	&	&	CCONJ
gs-4321	747	27	stegle	stegle	NOUN
gs-4321	747	28	,	,	PUNCT
gs-4321	747	29	o.	o.	NOUN
gs-4321	747	30	(	(	PUNCT
gs-4321	747	31	2020	2020	NUM
gs-4321	747	32	)	)	PUNCT
gs-4321	747	33	.	.	PUNCT
gs-4321	748	1	mofa+	mofa+	PROPN
gs-4321	748	2	:	:	PUNCT
gs-4321	748	3	a	a	DET
gs-4321	748	4	statistical	statistical	ADJ
gs-4321	748	5	framework	framework	NOUN
gs-4321	748	6	for	for	ADP
gs-4321	748	7	comprehensive	comprehensive	ADJ
gs-4321	748	8	integration	integration	NOUN
gs-4321	748	9	of	of	ADP
gs-4321	748	10	multi	multi	ADJ
gs-4321	748	11	-	-	ADJ
gs-4321	748	12	modal	modal	ADJ
gs-4321	748	13	single	single	ADJ
gs-4321	748	14	-	-	PUNCT
gs-4321	748	15	cell	cell	NOUN
gs-4321	748	16	data	datum	NOUN
gs-4321	748	17	.	.	PUNCT
gs-4321	749	1	genome	genome	NOUN
gs-4321	749	2	biology	biology	NOUN
gs-4321	749	3	,	,	PUNCT
gs-4321	749	4	21(1	21(1	NUM
gs-4321	749	5	)	)	PUNCT
gs-4321	749	6	,	,	PUNCT
gs-4321	749	7	111	111	NUM
gs-4321	749	8	.	.	PUNCT
gs-4321	750	1	balázsi	balázsi	NOUN
gs-4321	750	2	,	,	PUNCT
gs-4321	750	3	g.	g.	PROPN
gs-4321	750	4	,	,	PUNCT
gs-4321	750	5	van	van	PROPN
gs-4321	750	6	oudenaarden	oudenaarden	PROPN
gs-4321	750	7	,	,	PUNCT
gs-4321	750	8	a.	a.	PROPN
gs-4321	750	9	,	,	PUNCT
gs-4321	750	10	&	&	CCONJ
gs-4321	750	11	collins	collins	PROPN
gs-4321	750	12	,	,	PUNCT
gs-4321	750	13	j.	j.	PROPN
gs-4321	750	14	j.	j.	PROPN
gs-4321	750	15	(	(	PUNCT
gs-4321	750	16	2011	2011	NUM
gs-4321	750	17	)	)	PUNCT
gs-4321	750	18	.	.	PUNCT
gs-4321	751	1	cellular	cellular	ADJ
gs-4321	751	2	decision	decision	NOUN
gs-4321	751	3	making	making	NOUN
gs-4321	751	4	and	and	CCONJ
gs-4321	751	5	biological	biological	ADJ
gs-4321	751	6	noise	noise	NOUN
gs-4321	751	7	:	:	PUNCT
gs-4321	751	8	from	from	ADP
gs-4321	751	9	microbes	microbe	NOUN
gs-4321	751	10	to	to	ADP
gs-4321	751	11	mammals	mammal	NOUN
gs-4321	751	12	.	.	PUNCT
gs-4321	752	1	cell	cell	NOUN
gs-4321	752	2	,	,	PUNCT
gs-4321	752	3	144(6	144(6	NUM
gs-4321	752	4	)	)	PUNCT
gs-4321	752	5	,	,	PUNCT
gs-4321	752	6	910–925	910–925	NUM
gs-4321	752	7	.	.	PUNCT
gs-4321	752	8	batlle	batlle	NOUN
gs-4321	752	9	,	,	PUNCT
gs-4321	752	10	e.	e.	PROPN
gs-4321	752	11	,	,	PUNCT
gs-4321	752	12	&	&	CCONJ
gs-4321	752	13	clevers	clevers	PROPN
gs-4321	752	14	,	,	PUNCT
gs-4321	752	15	h.	h.	PROPN
gs-4321	752	16	(	(	PUNCT
gs-4321	752	17	2017	2017	NUM
gs-4321	752	18	)	)	PUNCT
gs-4321	752	19	.	.	PUNCT
gs-4321	753	1	cancer	cancer	NOUN
gs-4321	753	2	stem	stem	NOUN
gs-4321	753	3	cells	cell	NOUN
gs-4321	753	4	revisited	revisit	VERB
gs-4321	753	5	.	.	PUNCT
gs-4321	754	1	nature	nature	NOUN
gs-4321	754	2	medicine	medicine	NOUN
gs-4321	754	3	,	,	PUNCT
gs-4321	754	4	23(10	23(10	NUM
gs-4321	754	5	)	)	PUNCT
gs-4321	754	6	,	,	PUNCT
gs-4321	754	7	1124–1134	1124–1134	NUM
gs-4321	754	8	.	.	PUNCT
gs-4321	754	9	batlle	batlle	NOUN
gs-4321	754	10	,	,	PUNCT
gs-4321	754	11	e.	e.	PROPN
gs-4321	754	12	,	,	PUNCT
gs-4321	754	13	sancho	sancho	PROPN
gs-4321	754	14	,	,	PUNCT
gs-4321	754	15	e.	e.	PROPN
gs-4321	754	16	,	,	PUNCT
gs-4321	754	17	francí	francí	VERB
gs-4321	754	18	,	,	PUNCT
gs-4321	754	19	c.	c.	PROPN
gs-4321	754	20	,	,	PUNCT
gs-4321	754	21	domínguez	domínguez	NOUN
gs-4321	754	22	,	,	PUNCT
gs-4321	754	23	d.	d.	PROPN
gs-4321	754	24	,	,	PUNCT
gs-4321	754	25	monfar	monfar	ADV
gs-4321	754	26	,	,	PUNCT
gs-4321	754	27	m.	m.	NOUN
gs-4321	754	28	,	,	PUNCT
gs-4321	754	29	baulida	baulida	PROPN
gs-4321	754	30	,	,	PUNCT
gs-4321	754	31	j.	j.	PROPN
gs-4321	754	32	,	,	PUNCT
gs-4321	754	33	&	&	CCONJ
gs-4321	754	34	garcía	garcía	PROPN
gs-4321	754	35	de	de	PROPN
gs-4321	754	36	herreros	herreros	PROPN
gs-4321	754	37	,	,	PUNCT
gs-4321	754	38	a.	a.	NOUN
gs-4321	754	39	(	(	PUNCT
gs-4321	754	40	2000	2000	NUM
gs-4321	754	41	)	)	PUNCT
gs-4321	754	42	.	.	PUNCT
gs-4321	755	1	the	the	DET
gs-4321	755	2	transcription	transcription	NOUN
gs-4321	755	3	factor	factor	NOUN
gs-4321	755	4	snail	snail	NOUN
gs-4321	755	5	is	be	AUX
gs-4321	755	6	a	a	DET
gs-4321	755	7	repressor	repressor	NOUN
gs-4321	755	8	of	of	ADP
gs-4321	755	9	e	e	NOUN
gs-4321	755	10	-	-	NOUN
gs-4321	755	11	cadherin	cadherin	NOUN
gs-4321	755	12	gene	gene	NOUN
gs-4321	755	13	expression	expression	NOUN
gs-4321	755	14	in	in	ADP
gs-4321	755	15	epithelial	epithelial	ADJ
gs-4321	755	16	tumour	tumour	NOUN
gs-4321	755	17	cells	cell	NOUN
gs-4321	755	18	.	.	PUNCT
gs-4321	756	1	nature	nature	NOUN
gs-4321	756	2	cell	cell	NOUN
gs-4321	756	3	biology	biology	NOUN
gs-4321	756	4	,	,	PUNCT
gs-4321	756	5	2(2	2(2	NUM
gs-4321	756	6	)	)	PUNCT
gs-4321	756	7	,	,	PUNCT
gs-4321	756	8	84–89	84–89	NUM
gs-4321	756	9	.	.	PUNCT
gs-4321	757	1	becker	becker	PROPN
gs-4321	757	2	,	,	PUNCT
gs-4321	757	3	a.	a.	PROPN
gs-4321	757	4	,	,	PUNCT
gs-4321	757	5	thakur	thakur	PROPN
gs-4321	757	6	,	,	PUNCT
gs-4321	757	7	b.	b.	PROPN
gs-4321	757	8	k.	k.	PROPN
gs-4321	757	9	,	,	PUNCT
gs-4321	757	10	weiss	weiss	PROPN
gs-4321	757	11	,	,	PUNCT
gs-4321	757	12	j.	j.	PROPN
gs-4321	757	13	m.	m.	PROPN
gs-4321	757	14	,	,	PUNCT
gs-4321	757	15	kim	kim	PROPN
gs-4321	757	16	,	,	PUNCT
gs-4321	757	17	h.	h.	PROPN
gs-4321	757	18	s.	s.	PROPN
gs-4321	757	19	,	,	PUNCT
gs-4321	757	20	peinado	peinado	PROPN
gs-4321	757	21	,	,	PUNCT
gs-4321	757	22	h.	h.	PROPN
gs-4321	757	23	,	,	PUNCT
gs-4321	757	24	&	&	CCONJ
gs-4321	757	25	lyden	lyden	PROPN
gs-4321	757	26	,	,	PUNCT
gs-4321	757	27	d.	d.	PROPN
gs-4321	757	28	(	(	PUNCT
gs-4321	757	29	2016	2016	NUM
gs-4321	757	30	)	)	PUNCT
gs-4321	757	31	.	.	PUNCT
gs-4321	758	1	extracellular	extracellular	ADJ
gs-4321	758	2	vesicles	vesicle	NOUN
gs-4321	758	3	in	in	ADP
gs-4321	758	4	cancer	cancer	NOUN
gs-4321	758	5	:	:	PUNCT
gs-4321	758	6	cell	cell	NOUN
gs-4321	758	7	-	-	PUNCT
gs-4321	758	8	to	to	ADP
gs-4321	758	9	-	-	PUNCT
gs-4321	758	10	cell	cell	NOUN
gs-4321	758	11	mediators	mediator	NOUN
gs-4321	758	12	of	of	ADP
gs-4321	758	13	metastasis	metastasis	NOUN
gs-4321	758	14	.	.	PUNCT
gs-4321	759	1	cancer	cancer	NOUN
gs-4321	759	2	cell	cell	NOUN
gs-4321	759	3	,	,	PUNCT
gs-4321	759	4	30(6	30(6	NUM
gs-4321	759	5	)	)	PUNCT
gs-4321	759	6	,	,	PUNCT
gs-4321	759	7	836–848	836–848	NUM
gs-4321	759	8	.	.	PUNCT
gs-4321	760	1	benci	benci	PROPN
gs-4321	760	2	,	,	PUNCT
gs-4321	760	3	j.	j.	PROPN
gs-4321	760	4	l.	l.	PROPN
gs-4321	760	5	,	,	PUNCT
gs-4321	760	6	xu	xu	PROPN
gs-4321	760	7	,	,	PUNCT
gs-4321	760	8	b.	b.	PROPN
gs-4321	760	9	,	,	PUNCT
gs-4321	760	10	qiu	qiu	PROPN
gs-4321	760	11	,	,	PUNCT
gs-4321	760	12	y.	y.	PROPN
gs-4321	760	13	,	,	PUNCT
gs-4321	760	14	wu	wu	PROPN
gs-4321	760	15	,	,	PUNCT
gs-4321	760	16	t.	t.	PROPN
gs-4321	760	17	j.	j.	PROPN
gs-4321	760	18	(	(	PUNCT
gs-4321	760	19	2016	2016	NUM
gs-4321	760	20	)	)	PUNCT
gs-4321	760	21	.	.	PUNCT
gs-4321	761	1	tumor	tumor	PROPN
gs-4321	761	2	interferon	interferon	PROPN
gs-4321	761	3	signaling	signal	VERB
gs-4321	761	4	regulates	regulate	VERB
gs-4321	761	5	a	a	DET
gs-4321	761	6	multigenic	multigenic	ADJ
gs-4321	761	7	resistance	resistance	NOUN
gs-4321	761	8	program	program	NOUN
gs-4321	761	9	to	to	ADP
gs-4321	761	10	immune	immune	ADJ
gs-4321	761	11	checkpoint	checkpoint	NOUN
gs-4321	761	12	blockade	blockade	NOUN
gs-4321	761	13	.	.	PUNCT
gs-4321	762	1	cell	cell	NOUN
gs-4321	762	2	,	,	PUNCT
gs-4321	762	3	167(6	167(6	NUM
gs-4321	762	4	)	)	PUNCT
gs-4321	762	5	,	,	PUNCT
gs-4321	762	6	1540	1540	NUM
gs-4321	762	7	–	–	PUNCT
gs-4321	762	8	1554.e12	1554.e12	NOUN
gs-4321	762	9	.	.	PUNCT
gs-4321	763	1	bergen	bergen	PROPN
gs-4321	763	2	,	,	PUNCT
gs-4321	763	3	v.	v.	PROPN
gs-4321	763	4	,	,	PUNCT
gs-4321	763	5	lange	lange	NOUN
gs-4321	763	6	,	,	PUNCT
gs-4321	763	7	m.	m.	NOUN
gs-4321	763	8	,	,	PUNCT
gs-4321	763	9	peidli	peidli	PROPN
gs-4321	763	10	,	,	PUNCT
gs-4321	763	11	s.	s.	PROPN
gs-4321	763	12	,	,	PUNCT
gs-4321	763	13	wolf	wolf	PROPN
gs-4321	763	14	,	,	PUNCT
gs-4321	763	15	f.	f.	PROPN
gs-4321	763	16	a.	a.	PROPN
gs-4321	763	17	,	,	PUNCT
gs-4321	763	18	&	&	CCONJ
gs-4321	763	19	theis	theis	PROPN
gs-4321	763	20	,	,	PUNCT
gs-4321	763	21	f.	f.	PROPN
gs-4321	763	22	j.	j.	PROPN
gs-4321	763	23	(	(	PUNCT
gs-4321	763	24	2020	2020	NUM
gs-4321	763	25	)	)	PUNCT
gs-4321	763	26	.	.	PUNCT
gs-4321	764	1	generalizing	generalize	VERB
gs-4321	764	2	rna	rna	NOUN
gs-4321	764	3	velocity	velocity	NOUN
gs-4321	764	4	to	to	PART
gs-4321	764	5	transient	transient	VERB
gs-4321	764	6	cell	cell	NOUN
gs-4321	764	7	states	state	NOUN
gs-4321	764	8	through	through	ADP
gs-4321	764	9	dynamical	dynamical	ADJ
gs-4321	764	10	modeling	modeling	NOUN
gs-4321	764	11	.	.	PUNCT
gs-4321	765	1	nature	nature	NOUN
gs-4321	765	2	biotechnology	biotechnology	NOUN
gs-4321	765	3	,	,	PUNCT
gs-4321	765	4	38(12	38(12	NUM
gs-4321	765	5	)	)	PUNCT
gs-4321	765	6	,	,	PUNCT
gs-4321	765	7	1408–1414	1408–1414	NUM
gs-4321	765	8	.	.	PUNCT
gs-4321	766	1	boumahdi	boumahdi	NOUN
gs-4321	766	2	,	,	PUNCT
gs-4321	766	3	s.	s.	PROPN
gs-4321	766	4	,	,	PUNCT
gs-4321	766	5	&	&	CCONJ
gs-4321	766	6	de	de	X
gs-4321	766	7	sauvage	sauvage	PROPN
gs-4321	766	8	,	,	PUNCT
gs-4321	766	9	f.	f.	PROPN
gs-4321	766	10	j.	j.	PROPN
gs-4321	766	11	(	(	PUNCT
gs-4321	766	12	2020	2020	NUM
gs-4321	766	13	)	)	PUNCT
gs-4321	766	14	.	.	PUNCT
gs-4321	767	1	the	the	DET
gs-4321	767	2	great	great	ADJ
gs-4321	767	3	escape	escape	NOUN
gs-4321	767	4	:	:	PUNCT
gs-4321	767	5	tumour	tumour	NOUN
gs-4321	767	6	cell	cell	NOUN
gs-4321	767	7	plasticity	plasticity	NOUN
gs-4321	767	8	in	in	ADP
gs-4321	767	9	resistance	resistance	NOUN
gs-4321	767	10	to	to	ADP
gs-4321	767	11	targeted	target	VERB
gs-4321	767	12	therapy	therapy	NOUN
gs-4321	767	13	.	.	PUNCT
gs-4321	768	1	nature	nature	NOUN
gs-4321	768	2	reviews	review	VERB
gs-4321	768	3	drug	drug	NOUN
gs-4321	768	4	discovery	discovery	NOUN
gs-4321	768	5	,	,	PUNCT
gs-4321	768	6	19(1	19(1	NUM
gs-4321	768	7	)	)	PUNCT
gs-4321	768	8	,	,	PUNCT
gs-4321	768	9	39–56	39–56	NUM
gs-4321	768	10	.	.	PUNCT
gs-4321	769	1	browaeys	browaey	NOUN
gs-4321	769	2	,	,	PUNCT
gs-4321	769	3	r.	r.	PROPN
gs-4321	769	4	,	,	PUNCT
gs-4321	769	5	saelens	saelens	PROPN
gs-4321	769	6	,	,	PUNCT
gs-4321	769	7	w.	w.	PROPN
gs-4321	769	8	,	,	PUNCT
gs-4321	769	9	&	&	CCONJ
gs-4321	769	10	saeys	saey	NOUN
gs-4321	769	11	,	,	PUNCT
gs-4321	769	12	y.	y.	PROPN
gs-4321	769	13	(	(	PUNCT
gs-4321	769	14	2020	2020	NUM
gs-4321	769	15	)	)	PUNCT
gs-4321	769	16	.	.	PUNCT
gs-4321	770	1	nichenet	nichenet	NOUN
gs-4321	770	2	:	:	PUNCT
gs-4321	770	3	modeling	model	VERB
gs-4321	770	4	intercellular	intercellular	ADJ
gs-4321	770	5	communication	communication	NOUN
gs-4321	770	6	by	by	ADP
gs-4321	770	7	linking	link	VERB
gs-4321	770	8	ligands	ligand	NOUN
gs-4321	770	9	to	to	PART
gs-4321	770	10	target	target	VERB
gs-4321	770	11	genes	gene	NOUN
gs-4321	770	12	.	.	PUNCT
gs-4321	771	1	nature	nature	NOUN
gs-4321	771	2	methods	method	NOUN
gs-4321	771	3	,	,	PUNCT
gs-4321	771	4	17(2	17(2	NUM
gs-4321	771	5	)	)	PUNCT
gs-4321	771	6	,	,	PUNCT
gs-4321	771	7	159–162	159–162	NUM
gs-4321	771	8	.	.	PUNCT
gs-4321	772	1	buenrostro	buenrostro	PROPN
gs-4321	772	2	,	,	PUNCT
gs-4321	772	3	j.	j.	PROPN
gs-4321	772	4	d.	d.	PROPN
gs-4321	772	5	,	,	PUNCT
gs-4321	772	6	wu	wu	PROPN
gs-4321	772	7	,	,	PUNCT
gs-4321	772	8	b.	b.	PROPN
gs-4321	772	9	,	,	PUNCT
gs-4321	772	10	chang	chang	PROPN
gs-4321	772	11	,	,	PUNCT
gs-4321	772	12	h.	h.	PROPN
gs-4321	772	13	y.	y.	PROPN
gs-4321	772	14	,	,	PUNCT
gs-4321	772	15	&	&	CCONJ
gs-4321	772	16	greenleaf	greenleaf	PROPN
gs-4321	772	17	,	,	PUNCT
gs-4321	772	18	w.	w.	PROPN
gs-4321	772	19	j.	j.	PROPN
gs-4321	772	20	(	(	PUNCT
gs-4321	772	21	2015	2015	NUM
gs-4321	772	22	)	)	PUNCT
gs-4321	772	23	.	.	PUNCT
gs-4321	773	1	atac	atac	PROPN
gs-4321	773	2	-	-	PUNCT
gs-4321	773	3	seq	seq	PROPN
gs-4321	773	4	:	:	PUNCT
gs-4321	773	5	a	a	DET
gs-4321	773	6	method	method	NOUN
gs-4321	773	7	for	for	ADP
gs-4321	773	8	assaying	assay	VERB
gs-4321	773	9	chromatin	chromatin	NOUN
gs-4321	773	10	accessibility	accessibility	NOUN
gs-4321	773	11	genome	genome	NOUN
gs-4321	773	12	-	-	PUNCT
gs-4321	773	13	wide	wide	ADV
gs-4321	773	14	.	.	PUNCT
gs-4321	774	1	current	current	ADJ
gs-4321	774	2	protocols	protocol	NOUN
gs-4321	774	3	in	in	ADP
gs-4321	774	4	molecular	molecular	ADJ
gs-4321	774	5	biology	biology	NOUN
gs-4321	774	6	,	,	PUNCT
gs-4321	774	7	109(1	109(1	NUM
gs-4321	774	8	)	)	PUNCT
gs-4321	774	9	,	,	PUNCT
gs-4321	774	10	21.29.1–21.29.9	21.29.1–21.29.9	NUM
gs-4321	774	11	.	.	PUNCT
gs-4321	774	12	carette	carette	PROPN
gs-4321	774	13	,	,	PUNCT
gs-4321	774	14	d.	d.	PROPN
gs-4321	774	15	,	,	PUNCT
gs-4321	774	16	gillard	gillard	PROPN
gs-4321	774	17	,	,	PUNCT
gs-4321	774	18	m.	m.	NOUN
gs-4321	774	19	,	,	PUNCT
gs-4321	774	20	tost	tost	PROPN
gs-4321	774	21	,	,	PUNCT
gs-4321	774	22	j.	j.	PROPN
gs-4321	774	23	,	,	PUNCT
gs-4321	774	24	&	&	CCONJ
gs-4321	774	25	frommer	frommer	PROPN
gs-4321	774	26	,	,	PUNCT
gs-4321	774	27	m.	m.	NOUN
gs-4321	774	28	(	(	PUNCT
gs-4321	774	29	2019	2019	NUM
gs-4321	774	30	)	)	PUNCT
gs-4321	774	31	.	.	PUNCT
gs-4321	775	1	tgf	tgf	PROPN
gs-4321	775	2	and	and	CCONJ
gs-4321	775	3	cancer	cancer	NOUN
gs-4321	775	4	-	-	PUNCT
gs-4321	775	5	associated	associate	VERB
gs-4321	775	6	fibroblasts	fibroblast	NOUN
gs-4321	775	7	in	in	ADP
gs-4321	775	8	the	the	DET
gs-4321	775	9	breast	breast	NOUN
gs-4321	775	10	tumor	tumor	NOUN
gs-4321	775	11	microenvironment	microenvironment	NOUN
gs-4321	775	12	.	.	PUNCT
gs-4321	776	1	journal	journal	PROPN
gs-4321	776	2	of	of	ADP
gs-4321	776	3	mammary	mammary	ADJ
gs-4321	776	4	gland	gland	NOUN
gs-4321	776	5	biology	biology	NOUN
gs-4321	776	6	and	and	CCONJ
gs-4321	776	7	neoplasia	neoplasia	NOUN
gs-4321	776	8	,	,	PUNCT
gs-4321	776	9	24	24	NUM
gs-4321	776	10	,	,	PUNCT
gs-4321	776	11	63–75	63–75	NUM
gs-4321	776	12	.	.	PUNCT
gs-4321	777	1	cassetta	cassetta	NOUN
gs-4321	777	2	,	,	PUNCT
gs-4321	777	3	l.	l.	PROPN
gs-4321	777	4	,	,	PUNCT
gs-4321	777	5	&	&	CCONJ
gs-4321	777	6	pollard	pollard	PROPN
gs-4321	777	7	,	,	PUNCT
gs-4321	777	8	j.	j.	PROPN
gs-4321	777	9	w.	w.	PROPN
gs-4321	777	10	(	(	PUNCT
gs-4321	777	11	2018	2018	NUM
gs-4321	777	12	)	)	PUNCT
gs-4321	777	13	.	.	PUNCT
gs-4321	778	1	targeting	target	VERB
gs-4321	778	2	macrophages	macrophage	NOUN
gs-4321	778	3	:	:	PUNCT
gs-4321	778	4	therapeutic	therapeutic	ADJ
gs-4321	778	5	approaches	approach	NOUN
gs-4321	778	6	in	in	ADP
gs-4321	778	7	cancer	cancer	NOUN
gs-4321	778	8	.	.	PUNCT
gs-4321	779	1	nature	nature	NOUN
gs-4321	779	2	reviews	review	VERB
gs-4321	779	3	drug	drug	NOUN
gs-4321	779	4	discovery	discovery	NOUN
gs-4321	779	5	,	,	PUNCT
gs-4321	779	6	17(12	17(12	NUM
gs-4321	779	7	)	)	PUNCT
gs-4321	779	8	,	,	PUNCT
gs-4321	779	9	887–904	887–904	NUM
gs-4321	779	10	.	.	PUNCT
gs-4321	780	1	cassetta	cassetta	NOUN
gs-4321	780	2	,	,	PUNCT
gs-4321	780	3	l.	l.	PROPN
gs-4321	780	4	,	,	PUNCT
gs-4321	780	5	&	&	CCONJ
gs-4321	780	6	pollard	pollard	PROPN
gs-4321	780	7	,	,	PUNCT
gs-4321	780	8	j.	j.	PROPN
gs-4321	780	9	w.	w.	PROPN
gs-4321	780	10	(	(	PUNCT
gs-4321	780	11	2020	2020	NUM
gs-4321	780	12	)	)	PUNCT
gs-4321	780	13	.	.	PUNCT
gs-4321	781	1	tumor	tumor	NOUN
gs-4321	781	2	-	-	PUNCT
gs-4321	781	3	associated	associate	VERB
gs-4321	781	4	macrophages	macrophage	NOUN
gs-4321	781	5	.	.	PUNCT
gs-4321	782	1	current	current	ADJ
gs-4321	782	2	biology	biology	NOUN
gs-4321	782	3	,	,	PUNCT
gs-4321	782	4	30(6	30(6	NUM
gs-4321	782	5	)	)	PUNCT
gs-4321	782	6	,	,	PUNCT
gs-4321	782	7	r246	r246	NUM
gs-4321	782	8	–	–	PUNCT
gs-4321	782	9	r248	r248	PROPN
gs-4321	782	10	.	.	PUNCT
gs-4321	782	11	chaffer	chaffer	NOUN
gs-4321	782	12	,	,	PUNCT
gs-4321	782	13	c.	c.	PROPN
gs-4321	782	14	l.	l.	PROPN
gs-4321	782	15	,	,	PUNCT
gs-4321	782	16	marjanovic	marjanovic	PROPN
gs-4321	782	17	,	,	PUNCT
gs-4321	782	18	n.	n.	PROPN
gs-4321	782	19	d.	d.	PROPN
gs-4321	782	20	,	,	PUNCT
gs-4321	782	21	lee	lee	PROPN
gs-4321	782	22	,	,	PUNCT
gs-4321	782	23	t.	t.	PROPN
gs-4321	782	24	,	,	PUNCT
gs-4321	782	25	bell	bell	PROPN
gs-4321	782	26	,	,	PUNCT
gs-4321	782	27	g.	g.	PROPN
gs-4321	782	28	,	,	PUNCT
gs-4321	782	29	kleer	kleer	PROPN
gs-4321	782	30	,	,	PUNCT
gs-4321	782	31	c.	c.	PROPN
gs-4321	782	32	(	(	PUNCT
gs-4321	782	33	2013	2013	NUM
gs-4321	782	34	)	)	PUNCT
gs-4321	782	35	.	.	PUNCT
gs-4321	783	1	poised	poise	VERB
gs-4321	783	2	chromatin	chromatin	NOUN
gs-4321	783	3	at	at	ADP
gs-4321	783	4	the	the	DET
gs-4321	783	5	zeb1	zeb1	PROPN
gs-4321	783	6	promoter	promoter	NOUN
gs-4321	783	7	enables	enable	VERB
gs-4321	783	8	breast	breast	NOUN
gs-4321	783	9	cancer	cancer	NOUN
gs-4321	783	10	cell	cell	NOUN
gs-4321	783	11	plasticity	plasticity	NOUN
gs-4321	783	12	and	and	CCONJ
gs-4321	783	13	enhances	enhance	VERB
gs-4321	783	14	tumorigenicity	tumorigenicity	NOUN
gs-4321	783	15	.	.	PUNCT
gs-4321	784	1	cell	cell	NOUN
gs-4321	784	2	,	,	PUNCT
gs-4321	784	3	154(1	154(1	NUM
gs-4321	784	4	)	)	PUNCT
gs-4321	784	5	,	,	PUNCT
gs-4321	784	6	61–74	61–74	NUM
gs-4321	784	7	.	.	PUNCT
gs-4321	785	1	georgian	georgian	NOUN
gs-4321	785	2	scientists/	scientists/	NUM
gs-4321	785	3	.	.	PUNCT
gs-4321	786	1	7	7	NUM
gs-4321	786	2	n	n	DET
gs-4321	786	3	4	4	NUM
gs-4321	786	4	,	,	PUNCT
gs-4321	786	5	2025	2025	NUM
gs-4321	786	6	380	380	NUM
gs-4321	786	7	chevrier	chevrier	NOUN
gs-4321	786	8	,	,	PUNCT
gs-4321	786	9	s.	s.	PROPN
gs-4321	786	10	,	,	PUNCT
gs-4321	786	11	levine	levine	PROPN
gs-4321	786	12	,	,	PUNCT
gs-4321	786	13	j.	j.	PROPN
gs-4321	786	14	h.	h.	PROPN
gs-4321	786	15	,	,	PUNCT
gs-4321	786	16	zanotelli	zanotelli	PROPN
gs-4321	786	17	,	,	PUNCT
gs-4321	786	18	v.	v.	PROPN
gs-4321	786	19	r.	r.	PROPN
gs-4321	786	20	t.	t.	PROPN
gs-4321	786	21	,	,	PUNCT
gs-4321	786	22	silina	silina	PROPN
gs-4321	786	23	,	,	PUNCT
gs-4321	786	24	k.	k.	PROPN
gs-4321	786	25	,	,	PUNCT
gs-4321	786	26	schulz	schulz	PROPN
gs-4321	786	27	,	,	PUNCT
gs-4321	786	28	d.	d.	PROPN
gs-4321	786	29	,	,	PUNCT
gs-4321	786	30	bacac	bacac	NOUN
gs-4321	786	31	,	,	PUNCT
gs-4321	786	32	m.	m.	NOUN
gs-4321	786	33	,	,	PUNCT
gs-4321	786	34	ries	rie	NOUN
gs-4321	786	35	,	,	PUNCT
gs-4321	786	36	c.	c.	PROPN
gs-4321	786	37	h.	h.	PROPN
gs-4321	786	38	,	,	PUNCT
gs-4321	786	39	ailles	aille	NOUN
gs-4321	786	40	,	,	PUNCT
gs-4321	786	41	l.	l.	PROPN
gs-4321	786	42	,	,	PUNCT
gs-4321	786	43	jewett	jewett	PROPN
gs-4321	786	44	,	,	PUNCT
gs-4321	786	45	m.	m.	PROPN
gs-4321	786	46	a.	a.	PROPN
gs-4321	786	47	s.	s.	PROPN
gs-4321	786	48	,	,	PUNCT
gs-4321	786	49	moch	moch	PROPN
gs-4321	786	50	,	,	PUNCT
gs-4321	786	51	h.	h.	PROPN
gs-4321	786	52	,	,	PUNCT
gs-4321	786	53	van	van	PROPN
gs-4321	786	54	den	den	PROPN
gs-4321	786	55	broek	broek	PROPN
gs-4321	786	56	,	,	PUNCT
gs-4321	786	57	m.	m.	NOUN
gs-4321	786	58	,	,	PUNCT
gs-4321	786	59	beisel	beisel	NOUN
gs-4321	786	60	,	,	PUNCT
gs-4321	786	61	c.	c.	NOUN
gs-4321	786	62	,	,	PUNCT
gs-4321	786	63	stadler	stadler	NOUN
gs-4321	786	64	,	,	PUNCT
gs-4321	786	65	m.	m.	PROPN
gs-4321	786	66	b.	b.	PROPN
gs-4321	786	67	,	,	PUNCT
gs-4321	786	68	gedye	gedye	PROPN
gs-4321	786	69	,	,	PUNCT
gs-4321	786	70	c.	c.	PROPN
gs-4321	786	71	,	,	PUNCT
gs-4321	786	72	reis	reis	NOUN
gs-4321	786	73	,	,	PUNCT
gs-4321	786	74	b.	b.	PROPN
gs-4321	786	75	,	,	PUNCT
gs-4321	786	76	pe'er	pe'er	PROPN
gs-4321	786	77	,	,	PUNCT
gs-4321	786	78	d.	d.	PROPN
gs-4321	786	79	,	,	PUNCT
gs-4321	786	80	&	&	CCONJ
gs-4321	786	81	bodenmiller	bodenmiller	PROPN
gs-4321	786	82	,	,	PUNCT
gs-4321	786	83	b.	b.	PROPN
gs-4321	786	84	(	(	PUNCT
gs-4321	786	85	2018	2018	NUM
gs-4321	786	86	)	)	PUNCT
gs-4321	786	87	.	.	PUNCT
gs-4321	787	1	an	an	DET
gs-4321	787	2	immune	immune	ADJ
gs-4321	787	3	atlas	atlas	NOUN
gs-4321	787	4	of	of	ADP
gs-4321	787	5	clear	clear	ADJ
gs-4321	787	6	cell	cell	NOUN
gs-4321	787	7	renal	renal	ADJ
gs-4321	787	8	cell	cell	NOUN
gs-4321	787	9	carcinoma	carcinoma	NOUN
gs-4321	787	10	.	.	PUNCT
gs-4321	788	1	cell	cell	NOUN
gs-4321	788	2	,	,	PUNCT
gs-4321	788	3	169(4	169(4	NUM
gs-4321	788	4	)	)	PUNCT
gs-4321	788	5	,	,	PUNCT
gs-4321	788	6	736–749.e18	736–749.e18	PROPN
gs-4321	788	7	.	.	PUNCT
gs-4321	788	8	corces	corces	PROPN
gs-4321	788	9	,	,	PUNCT
gs-4321	788	10	m.	m.	PROPN
gs-4321	788	11	r.	r.	PROPN
gs-4321	788	12	,	,	PUNCT
gs-4321	788	13	granja	granja	NOUN
gs-4321	788	14	,	,	PUNCT
gs-4321	788	15	j.	j.	PROPN
gs-4321	788	16	m.	m.	PROPN
gs-4321	788	17	,	,	PUNCT
gs-4321	788	18	shams	sham	NOUN
gs-4321	788	19	,	,	PUNCT
gs-4321	788	20	s.	s.	PROPN
gs-4321	788	21	(	(	PUNCT
gs-4321	788	22	2018	2018	NUM
gs-4321	788	23	)	)	PUNCT
gs-4321	788	24	.	.	PUNCT
gs-4321	789	1	the	the	DET
gs-4321	789	2	chromatin	chromatin	NOUN
gs-4321	789	3	accessibility	accessibility	NOUN
gs-4321	789	4	landscape	landscape	NOUN
gs-4321	789	5	of	of	ADP
gs-4321	789	6	primary	primary	ADJ
gs-4321	789	7	human	human	ADJ
gs-4321	789	8	cancers	cancer	NOUN
gs-4321	789	9	.	.	PUNCT
gs-4321	790	1	science	science	NOUN
gs-4321	790	2	,	,	PUNCT
gs-4321	790	3	362(6413	362(6413	NUM
gs-4321	790	4	)	)	PUNCT
gs-4321	790	5	,	,	PUNCT
gs-4321	790	6	eaav1898	eaav1898	PROPN
gs-4321	790	7	.	.	PUNCT
gs-4321	790	8	cusanovich	cusanovich	PROPN
gs-4321	790	9	,	,	PUNCT
gs-4321	790	10	d.	d.	PROPN
gs-4321	790	11	a.	a.	PROPN
gs-4321	790	12	,	,	PUNCT
gs-4321	790	13	hill	hill	PROPN
gs-4321	790	14	,	,	PUNCT
gs-4321	790	15	a.	a.	PROPN
gs-4321	790	16	j.	j.	PROPN
gs-4321	790	17	,	,	PUNCT
gs-4321	790	18	aghamirzaie	aghamirzaie	PROPN
gs-4321	790	19	,	,	PUNCT
gs-4321	790	20	d.	d.	PROPN
gs-4321	790	21	,	,	PUNCT
gs-4321	790	22	daza	daza	PROPN
gs-4321	790	23	,	,	PUNCT
gs-4321	790	24	r.	r.	PROPN
gs-4321	790	25	m.(2018	m.(2018	PROPN
gs-4321	790	26	)	)	PUNCT
gs-4321	790	27	.	.	PUNCT
gs-4321	791	1	a	a	DET
gs-4321	791	2	single	single	ADJ
gs-4321	791	3	-	-	PUNCT
gs-4321	791	4	cell	cell	NOUN
gs-4321	791	5	atlas	atla	NOUN
gs-4321	791	6	of	of	ADP
gs-4321	791	7	in	in	ADP
gs-4321	791	8	vivo	vivo	ADJ
gs-4321	791	9	mammalian	mammalian	ADJ
gs-4321	791	10	chromatin	chromatin	NOUN
gs-4321	791	11	accessibility	accessibility	NOUN
gs-4321	791	12	.	.	PUNCT
gs-4321	792	1	cell	cell	NOUN
gs-4321	792	2	,	,	PUNCT
gs-4321	792	3	174(5	174(5	NUM
gs-4321	792	4	)	)	PUNCT
gs-4321	792	5	,	,	PUNCT
gs-4321	792	6	1309–1324.e18	1309–1324.e18	NUM
gs-4321	792	7	.	.	PUNCT
gs-4321	792	8	dongre	dongre	PROPN
gs-4321	792	9	,	,	PUNCT
gs-4321	792	10	a.	a.	NOUN
gs-4321	792	11	,	,	PUNCT
gs-4321	792	12	&	&	CCONJ
gs-4321	792	13	weinberg	weinberg	PROPN
gs-4321	792	14	,	,	PUNCT
gs-4321	792	15	r.	r.	PROPN
gs-4321	792	16	a.	a.	PROPN
gs-4321	792	17	(	(	PUNCT
gs-4321	792	18	2019	2019	NUM
gs-4321	792	19	)	)	PUNCT
gs-4321	792	20	.	.	PUNCT
gs-4321	793	1	new	new	ADJ
gs-4321	793	2	insights	insight	NOUN
gs-4321	793	3	into	into	ADP
gs-4321	793	4	the	the	DET
gs-4321	793	5	mechanisms	mechanism	NOUN
gs-4321	793	6	of	of	ADP
gs-4321	793	7	epithelial	epithelial	ADJ
gs-4321	793	8	–	–	PUNCT
gs-4321	793	9	mesenchymal	mesenchymal	ADJ
gs-4321	793	10	transition	transition	NOUN
gs-4321	793	11	and	and	CCONJ
gs-4321	793	12	implications	implication	NOUN
gs-4321	793	13	for	for	ADP
gs-4321	793	14	cancer	cancer	NOUN
gs-4321	793	15	.	.	PUNCT
gs-4321	794	1	nature	nature	NOUN
gs-4321	794	2	reviews	review	VERB
gs-4321	794	3	molecular	molecular	ADJ
gs-4321	794	4	cell	cell	NOUN
gs-4321	794	5	biology	biology	NOUN
gs-4321	794	6	,	,	PUNCT
gs-4321	794	7	20(2	20(2	NUM
gs-4321	794	8	)	)	PUNCT
gs-4321	794	9	,	,	PUNCT
gs-4321	794	10	69–84	69–84	PROPN
gs-4321	794	11	.	.	PUNCT
gs-4321	795	1	efremova	efremova	PROPN
gs-4321	795	2	,	,	PUNCT
gs-4321	795	3	m.	m.	NOUN
gs-4321	795	4	,	,	PUNCT
gs-4321	795	5	vento	vento	NOUN
gs-4321	795	6	-	-	PUNCT
gs-4321	795	7	tormo	tormo	NOUN
gs-4321	795	8	,	,	PUNCT
gs-4321	795	9	m.	m.	NOUN
gs-4321	795	10	,	,	PUNCT
gs-4321	795	11	teichmann	teichmann	PROPN
gs-4321	795	12	,	,	PUNCT
gs-4321	795	13	s.	s.	PROPN
gs-4321	795	14	a.	a.	PROPN
gs-4321	795	15	,	,	PUNCT
gs-4321	795	16	&	&	CCONJ
gs-4321	795	17	vento	vento	NOUN
gs-4321	795	18	-	-	PUNCT
gs-4321	795	19	tormo	tormo	PROPN
gs-4321	795	20	,	,	PUNCT
gs-4321	795	21	r.	r.	PROPN
gs-4321	795	22	(	(	PUNCT
gs-4321	795	23	2020	2020	NUM
gs-4321	795	24	)	)	PUNCT
gs-4321	795	25	.	.	PUNCT
gs-4321	796	1	cellphonedb	cellphonedb	NOUN
gs-4321	796	2	:	:	PUNCT
gs-4321	796	3	inferring	infer	VERB
gs-4321	796	4	cell	cell	NOUN
gs-4321	796	5	–	–	PUNCT
gs-4321	796	6	cell	cell	NOUN
gs-4321	796	7	communication	communication	NOUN
gs-4321	796	8	from	from	ADP
gs-4321	796	9	combined	combined	ADJ
gs-4321	796	10	expression	expression	NOUN
gs-4321	796	11	of	of	ADP
gs-4321	796	12	multi	multi	ADJ
gs-4321	796	13	-	-	ADJ
gs-4321	796	14	subunit	subunit	ADJ
gs-4321	796	15	ligand	ligand	NOUN
gs-4321	796	16	–	–	PUNCT
gs-4321	796	17	receptor	receptor	NOUN
gs-4321	796	18	complexes	complex	NOUN
gs-4321	796	19	.	.	PUNCT
gs-4321	797	1	nature	nature	NOUN
gs-4321	797	2	protocols	protocol	NOUN
gs-4321	797	3	,	,	PUNCT
gs-4321	797	4	15(4	15(4	NUM
gs-4321	797	5	)	)	PUNCT
gs-4321	797	6	,	,	PUNCT
gs-4321	797	7	1484–1506	1484–1506	NUM
gs-4321	797	8	.	.	PUNCT
gs-4321	798	1	falletta	falletta	ADJ
gs-4321	798	2	,	,	PUNCT
gs-4321	798	3	p.	p.	NOUN
gs-4321	798	4	,	,	PUNCT
gs-4321	798	5	sanchez	sanchez	PROPN
gs-4321	798	6	-	-	PUNCT
gs-4321	798	7	del	del	NOUN
gs-4321	798	8	-	-	PUNCT
gs-4321	798	9	campo	campo	NOUN
gs-4321	798	10	,	,	PUNCT
gs-4321	798	11	l.	l.	PROPN
gs-4321	798	12	,	,	PUNCT
gs-4321	798	13	chauhan	chauhan	PROPN
gs-4321	798	14	,	,	PUNCT
gs-4321	798	15	j.	j.	PROPN
gs-4321	798	16	,	,	PUNCT
gs-4321	798	17	effern	effern	ADJ
gs-4321	798	18	,	,	PUNCT
gs-4321	798	19	m.	m.	NOUN
gs-4321	798	20	,	,	PUNCT
gs-4321	798	21	kenyon	kenyon	PROPN
gs-4321	798	22	,	,	PUNCT
gs-4321	798	23	a.	a.	PROPN
gs-4321	798	24	,	,	PUNCT
gs-4321	798	25	kershaw	kershaw	PROPN
gs-4321	798	26	,	,	PUNCT
gs-4321	798	27	c.	c.	PROPN
gs-4321	798	28	j.	j.	PROPN
gs-4321	798	29	,	,	PUNCT
gs-4321	798	30	siddaway	siddaway	PROPN
gs-4321	798	31	,	,	PUNCT
gs-4321	798	32	r.	r.	PROPN
gs-4321	798	33	,	,	PUNCT
gs-4321	798	34	lisle	lisle	PROPN
gs-4321	798	35	,	,	PUNCT
gs-4321	798	36	r.	r.	PROPN
gs-4321	798	37	,	,	PUNCT
gs-4321	798	38	freter	freter	NOUN
gs-4321	798	39	,	,	PUNCT
gs-4321	798	40	r.	r.	PROPN
gs-4321	798	41	,	,	PUNCT
gs-4321	798	42	daniels	daniels	PROPN
gs-4321	798	43	.	.	PUNCT
gs-4321	799	1	(	(	PUNCT
gs-4321	799	2	2017	2017	NUM
gs-4321	799	3	)	)	PUNCT
gs-4321	799	4	.	.	PUNCT
gs-4321	800	1	translation	translation	NOUN
gs-4321	800	2	reprogramming	reprogramme	VERB
gs-4321	800	3	is	be	AUX
gs-4321	800	4	an	an	DET
gs-4321	800	5	evolutionarily	evolutionarily	ADV
gs-4321	800	6	conserved	conserve	VERB
gs-4321	800	7	driver	driver	NOUN
gs-4321	800	8	of	of	ADP
gs-4321	800	9	phenotypic	phenotypic	ADJ
gs-4321	800	10	plasticity	plasticity	NOUN
gs-4321	800	11	and	and	CCONJ
gs-4321	800	12	therapeutic	therapeutic	ADJ
gs-4321	800	13	resistance	resistance	NOUN
gs-4321	800	14	in	in	ADP
gs-4321	800	15	melanoma	melanoma	NOUN
gs-4321	800	16	.	.	PUNCT
gs-4321	801	1	genes	gene	NOUN
gs-4321	801	2	&	&	CCONJ
gs-4321	801	3	development	development	NOUN
gs-4321	801	4	,	,	PUNCT
gs-4321	801	5	31(1	31(1	NUM
gs-4321	801	6	)	)	PUNCT
gs-4321	801	7	,	,	PUNCT
gs-4321	801	8	18–33	18–33	NUM
gs-4321	801	9	.	.	PUNCT
gs-4321	802	1	faubert	faubert	PROPN
gs-4321	802	2	,	,	PUNCT
gs-4321	802	3	b.	b.	PROPN
gs-4321	802	4	,	,	PUNCT
gs-4321	802	5	solmonson	solmonson	PROPN
gs-4321	802	6	,	,	PUNCT
gs-4321	802	7	a.	a.	PROPN
gs-4321	802	8	,	,	PUNCT
gs-4321	802	9	&	&	CCONJ
gs-4321	802	10	deberardinis	deberardinis	PROPN
gs-4321	802	11	,	,	PUNCT
gs-4321	802	12	r.	r.	PROPN
gs-4321	802	13	j.	j.	PROPN
gs-4321	802	14	(	(	PUNCT
gs-4321	802	15	2020	2020	NUM
gs-4321	802	16	)	)	PUNCT
gs-4321	802	17	.	.	PUNCT
gs-4321	803	1	metabolic	metabolic	NOUN
gs-4321	803	2	reprogramming	reprogramming	NOUN
gs-4321	803	3	and	and	CCONJ
gs-4321	803	4	cancer	cancer	NOUN
gs-4321	803	5	progression	progression	NOUN
gs-4321	803	6	.	.	PUNCT
gs-4321	804	1	science	science	NOUN
gs-4321	804	2	,	,	PUNCT
gs-4321	804	3	368(6487	368(6487	NUM
gs-4321	804	4	)	)	PUNCT
gs-4321	804	5	,	,	PUNCT
gs-4321	804	6	eaaw5473	eaaw5473	PROPN
gs-4321	804	7	.	.	PUNCT
gs-4321	805	1	finnerty	finnerty	PROPN
gs-4321	805	2	,	,	PUNCT
gs-4321	805	3	b.	b.	PROPN
gs-4321	805	4	,	,	PUNCT
gs-4321	805	5	kleemann	kleemann	PROPN
gs-4321	805	6	,	,	PUNCT
gs-4321	805	7	s.	s.	PROPN
gs-4321	805	8	,	,	PUNCT
gs-4321	805	9	lei	lei	PROPN
gs-4321	805	10	,	,	PUNCT
gs-4321	805	11	x.	x.	NOUN
gs-4321	805	12	,	,	PUNCT
gs-4321	805	13	king	king	NOUN
gs-4321	805	14	,	,	PUNCT
gs-4321	805	15	m.	m.	PROPN
gs-4321	805	16	r.	r.	PROPN
gs-4321	805	17	,	,	PUNCT
gs-4321	805	18	zhao	zhao	PROPN
gs-4321	805	19	,	,	PUNCT
gs-4321	805	20	t.	t.	PROPN
gs-4321	805	21	,	,	PUNCT
gs-4321	805	22	hernandez	hernandez	PROPN
gs-4321	805	23	,	,	PUNCT
gs-4321	805	24	j.	j.	PROPN
gs-4321	805	25	m.	m.	PROPN
gs-4321	805	26	,	,	PUNCT
gs-4321	805	27	&	&	CCONJ
gs-4321	805	28	zarnegar	zarnegar	PROPN
gs-4321	805	29	,	,	PUNCT
gs-4321	805	30	r.	r.	PROPN
gs-4321	805	31	(	(	PUNCT
gs-4321	805	32	2022	2022	NUM
gs-4321	805	33	)	)	PUNCT
gs-4321	805	34	.	.	PUNCT
gs-4321	806	1	somatic	somatic	ADJ
gs-4321	806	2	chromatin	chromatin	NOUN
gs-4321	806	3	remodeling	remodeling	NOUN
gs-4321	806	4	mutations	mutation	NOUN
gs-4321	806	5	drive	drive	VERB
gs-4321	806	6	malignant	malignant	ADJ
gs-4321	806	7	transformation	transformation	NOUN
gs-4321	806	8	of	of	ADP
gs-4321	806	9	thyroid	thyroid	NOUN
gs-4321	806	10	nodules	nodule	NOUN
gs-4321	806	11	.	.	PUNCT
gs-4321	807	1	endocrine	endocrine	NOUN
gs-4321	807	2	-	-	PUNCT
gs-4321	807	3	related	relate	VERB
gs-4321	807	4	cancer	cancer	NOUN
gs-4321	807	5	,	,	PUNCT
gs-4321	807	6	29(5	29(5	NUM
gs-4321	807	7	)	)	PUNCT
gs-4321	807	8	,	,	PUNCT
gs-4321	807	9	269–278	269–278	NUM
gs-4321	807	10	.	.	PUNCT
gs-4321	807	11	francis	francis	PROPN
gs-4321	807	12	,	,	PUNCT
gs-4321	807	13	j.	j.	PROPN
gs-4321	807	14	m.	m.	PROPN
gs-4321	807	15	,	,	PUNCT
gs-4321	807	16	zhang	zhang	PROPN
gs-4321	807	17	,	,	PUNCT
gs-4321	807	18	c.	c.	PROPN
gs-4321	807	19	z.	z.	PROPN
gs-4321	807	20	,	,	PUNCT
gs-4321	807	21	maire	maire	PROPN
gs-4321	807	22	,	,	PUNCT
gs-4321	807	23	c.	c.	PROPN
gs-4321	807	24	l.	l.	PROPN
gs-4321	807	25	,	,	PUNCT
gs-4321	807	26	jung	jung	PROPN
gs-4321	807	27	.	.	PUNCT
gs-4321	808	1	(	(	PUNCT
gs-4321	808	2	2014	2014	NUM
gs-4321	808	3	)	)	PUNCT
gs-4321	808	4	.	.	PUNCT
gs-4321	809	1	egfr	egfr	ADJ
gs-4321	809	2	variant	variant	ADJ
gs-4321	809	3	heterogeneity	heterogeneity	NOUN
gs-4321	809	4	in	in	ADP
gs-4321	809	5	glioblastoma	glioblastoma	NOUN
gs-4321	809	6	resolved	resolve	VERB
gs-4321	809	7	through	through	ADP
gs-4321	809	8	single	single	ADJ
gs-4321	809	9	-	-	PUNCT
gs-4321	809	10	nucleus	nucleus	NOUN
gs-4321	809	11	sequencing	sequencing	NOUN
gs-4321	809	12	.	.	PUNCT
gs-4321	810	1	cancer	cancer	NOUN
gs-4321	810	2	discovery	discovery	NOUN
gs-4321	810	3	,	,	PUNCT
gs-4321	810	4	4(8	4(8	NUM
gs-4321	810	5	)	)	PUNCT
gs-4321	810	6	,	,	PUNCT
gs-4321	810	7	956–971	956–971	NUM
gs-4321	810	8	.	.	PUNCT
gs-4321	811	1	glodde	glodde	VERB
gs-4321	811	2	,	,	PUNCT
gs-4321	811	3	n.	n.	NOUN
gs-4321	811	4	,	,	PUNCT
gs-4321	811	5	bald	bald	ADJ
gs-4321	811	6	,	,	PUNCT
gs-4321	811	7	t.	t.	PROPN
gs-4321	811	8	,	,	PUNCT
gs-4321	811	9	van	van	PROPN
gs-4321	811	10	den	den	PROPN
gs-4321	811	11	boorn	boorn	NOUN
gs-4321	811	12	-	-	PUNCT
gs-4321	811	13	konijnenberg	konijnenberg	NOUN
gs-4321	811	14	,	,	PUNCT
gs-4321	811	15	d.	d.	PROPN
gs-4321	811	16	,	,	PUNCT
gs-4321	811	17	nakamura	nakamura	PROPN
gs-4321	811	18	,	,	PUNCT
gs-4321	811	19	k.	k.	PROPN
gs-4321	811	20	,	,	PUNCT
gs-4321	811	21	o'donnell	o'donnell	PROPN
gs-4321	811	22	,	,	PUNCT
gs-4321	811	23	j.	j.	PROPN
gs-4321	811	24	(	(	PUNCT
gs-4321	811	25	2017	2017	NUM
gs-4321	811	26	)	)	PUNCT
gs-4321	811	27	.	.	PUNCT
gs-4321	812	1	reactive	reactive	ADJ
gs-4321	812	2	neutrophil	neutrophil	ADJ
gs-4321	812	3	responses	response	NOUN
gs-4321	812	4	dependent	dependent	ADJ
gs-4321	812	5	on	on	ADP
gs-4321	812	6	the	the	DET
gs-4321	812	7	receptor	receptor	NOUN
gs-4321	812	8	tyrosine	tyrosine	PROPN
gs-4321	812	9	kinase	kinase	PROPN
gs-4321	812	10	cmet	cmet	PROPN
gs-4321	812	11	limit	limit	VERB
gs-4321	812	12	cancer	cancer	NOUN
gs-4321	812	13	immunotherapy	immunotherapy	NOUN
gs-4321	812	14	.	.	PUNCT
gs-4321	813	1	immunity	immunity	NOUN
gs-4321	813	2	,	,	PUNCT
gs-4321	813	3	47(4	47(4	PROPN
gs-4321	813	4	)	)	PUNCT
gs-4321	813	5	,	,	PUNCT
gs-4321	813	6	789–802.e9	789–802.e9	NUM
gs-4321	813	7	.	.	PUNCT
gs-4321	814	1	grivennikov	grivennikov	PROPN
gs-4321	814	2	,	,	PUNCT
gs-4321	814	3	s.	s.	PROPN
gs-4321	814	4	i.	i.	PROPN
gs-4321	814	5	,	,	PUNCT
gs-4321	814	6	greten	greten	PROPN
gs-4321	814	7	,	,	PUNCT
gs-4321	814	8	f.	f.	PROPN
gs-4321	814	9	r.	r.	PROPN
gs-4321	814	10	,	,	PUNCT
gs-4321	814	11	&	&	CCONJ
gs-4321	814	12	karin	karin	PROPN
gs-4321	814	13	,	,	PUNCT
gs-4321	814	14	m.	m.	NOUN
gs-4321	814	15	(	(	PUNCT
gs-4321	814	16	2010	2010	NUM
gs-4321	814	17	)	)	PUNCT
gs-4321	814	18	.	.	PUNCT
gs-4321	815	1	immunity	immunity	NOUN
gs-4321	815	2	,	,	PUNCT
gs-4321	815	3	inflammation	inflammation	NOUN
gs-4321	815	4	,	,	PUNCT
gs-4321	815	5	and	and	CCONJ
gs-4321	815	6	cancer	cancer	NOUN
gs-4321	815	7	.	.	PUNCT
gs-4321	816	1	cell	cell	NOUN
gs-4321	816	2	,	,	PUNCT
gs-4321	816	3	140(6	140(6	NUM
gs-4321	816	4	)	)	PUNCT
gs-4321	816	5	,	,	PUNCT
gs-4321	816	6	883–899	883–899	NUM
gs-4321	816	7	.	.	PUNCT
gs-4321	816	8	hangauer	hangauer	PROPN
gs-4321	816	9	,	,	PUNCT
gs-4321	816	10	m.	m.	NOUN
gs-4321	816	11	j.	j.	PROPN
gs-4321	816	12	,	,	PUNCT
gs-4321	816	13	viswanathan	viswanathan	PROPN
gs-4321	816	14	,	,	PUNCT
gs-4321	816	15	v.	v.	PROPN
gs-4321	816	16	s.	s.	PROPN
gs-4321	816	17	,	,	PUNCT
gs-4321	816	18	ryan	ryan	PROPN
gs-4321	816	19	,	,	PUNCT
gs-4321	816	20	m.	m.	NOUN
gs-4321	816	21	j.(2017	j.(2017	NOUN
gs-4321	816	22	)	)	PUNCT
gs-4321	816	23	.	.	PUNCT
gs-4321	817	1	drug	drug	NOUN
gs-4321	817	2	-	-	PUNCT
gs-4321	817	3	tolerant	tolerant	ADJ
gs-4321	817	4	persister	persister	NOUN
gs-4321	817	5	cancer	cancer	NOUN
gs-4321	817	6	cells	cell	NOUN
gs-4321	817	7	are	be	AUX
gs-4321	817	8	vulnerable	vulnerable	ADJ
gs-4321	817	9	to	to	ADP
gs-4321	817	10	gpx4	gpx4	NOUN
gs-4321	817	11	inhibition	inhibition	NOUN
gs-4321	817	12	.	.	PUNCT
gs-4321	818	1	nature	nature	NOUN
gs-4321	818	2	,	,	PUNCT
gs-4321	818	3	551(7679	551(7679	NUM
gs-4321	818	4	)	)	PUNCT
gs-4321	818	5	,	,	PUNCT
gs-4321	818	6	247–250	247–250	NUM
gs-4321	818	7	.	.	PUNCT
gs-4321	819	1	hao	hao	PROPN
gs-4321	819	2	,	,	PUNCT
gs-4321	819	3	y.	y.	PROPN
gs-4321	819	4	,	,	PUNCT
gs-4321	819	5	hao	hao	PROPN
gs-4321	819	6	,	,	PUNCT
gs-4321	819	7	s.	s.	PROPN
gs-4321	819	8	,	,	PUNCT
gs-4321	819	9	andersen	andersen	PROPN
gs-4321	819	10	-	-	PUNCT
gs-4321	819	11	nissen	nissen	PROPN
gs-4321	819	12	,	,	PUNCT
gs-4321	819	13	e.	e.	PROPN
gs-4321	819	14	(	(	PUNCT
gs-4321	819	15	2021	2021	NUM
gs-4321	819	16	)	)	PUNCT
gs-4321	819	17	.	.	PUNCT
gs-4321	820	1	integrated	integrate	VERB
gs-4321	820	2	analysis	analysis	NOUN
gs-4321	820	3	of	of	ADP
gs-4321	820	4	multimodal	multimodal	ADJ
gs-4321	820	5	single	single	ADJ
gs-4321	820	6	-	-	PUNCT
gs-4321	820	7	cell	cell	NOUN
gs-4321	820	8	data	datum	NOUN
gs-4321	820	9	.	.	PUNCT
gs-4321	821	1	cell	cell	NOUN
gs-4321	821	2	,	,	PUNCT
gs-4321	821	3	184(13	184(13	NUM
gs-4321	821	4	)	)	PUNCT
gs-4321	821	5	,	,	PUNCT
gs-4321	821	6	3573–3587.e29	3573–3587.e29	NUM
gs-4321	821	7	.	.	PUNCT
gs-4321	822	1	herman	herman	PROPN
gs-4321	822	2	,	,	PUNCT
gs-4321	822	3	j.	j.	PROPN
gs-4321	822	4	s.	s.	PROPN
gs-4321	822	5	,	,	PUNCT
gs-4321	822	6	sagar	sagar	PROPN
gs-4321	822	7	,	,	PUNCT
gs-4321	822	8	&	&	CCONJ
gs-4321	822	9	grün	grün	PROPN
gs-4321	822	10	,	,	PUNCT
gs-4321	822	11	d.	d.	PROPN
gs-4321	822	12	(	(	PUNCT
gs-4321	822	13	2018	2018	NUM
gs-4321	822	14	)	)	PUNCT
gs-4321	822	15	.	.	PUNCT
gs-4321	823	1	fateid	fateid	NOUN
gs-4321	823	2	infers	infer	NOUN
gs-4321	823	3	cell	cell	VERB
gs-4321	823	4	fate	fate	NOUN
gs-4321	823	5	bias	bias	NOUN
gs-4321	823	6	in	in	ADP
gs-4321	823	7	multipotent	multipotent	NOUN
gs-4321	823	8	progenitors	progenitor	NOUN
gs-4321	823	9	from	from	ADP
gs-4321	823	10	single	single	ADJ
gs-4321	823	11	-	-	PUNCT
gs-4321	823	12	cell	cell	NOUN
gs-4321	823	13	rna	rna	NOUN
gs-4321	823	14	-	-	PUNCT
gs-4321	823	15	seq	seq	NOUN
gs-4321	823	16	data	datum	NOUN
gs-4321	823	17	.	.	PUNCT
gs-4321	824	1	nature	nature	NOUN
gs-4321	824	2	methods	method	NOUN
gs-4321	824	3	,	,	PUNCT
gs-4321	824	4	15(5	15(5	NUM
gs-4321	824	5	)	)	PUNCT
gs-4321	824	6	,	,	PUNCT
gs-4321	824	7	379–386	379–386	NUM
gs-4321	824	8	.	.	PUNCT
gs-4321	825	1	iacono	iacono	PROPN
gs-4321	825	2	,	,	PUNCT
gs-4321	825	3	g.	g.	PROPN
gs-4321	825	4	,	,	PUNCT
gs-4321	825	5	massoni	massoni	NOUN
gs-4321	825	6	-	-	PUNCT
gs-4321	825	7	badosa	badosa	PROPN
gs-4321	825	8	,	,	PUNCT
gs-4321	825	9	r.	r.	PROPN
gs-4321	825	10	,	,	PUNCT
gs-4321	825	11	&	&	CCONJ
gs-4321	825	12	heyn	heyn	PROPN
gs-4321	825	13	,	,	PUNCT
gs-4321	825	14	h.	h.	PROPN
gs-4321	825	15	(	(	PUNCT
gs-4321	825	16	2019	2019	NUM
gs-4321	825	17	)	)	PUNCT
gs-4321	825	18	.	.	PUNCT
gs-4321	826	1	single	single	ADJ
gs-4321	826	2	-	-	PUNCT
gs-4321	826	3	cell	cell	NOUN
gs-4321	826	4	transcriptomics	transcriptomic	NOUN
gs-4321	826	5	unveils	unveil	VERB
gs-4321	826	6	gene	gene	NOUN
gs-4321	826	7	regulatory	regulatory	ADJ
gs-4321	826	8	network	network	NOUN
gs-4321	826	9	plasticity	plasticity	NOUN
gs-4321	826	10	.	.	PUNCT
gs-4321	827	1	genome	genome	NOUN
gs-4321	827	2	biology	biology	NOUN
gs-4321	827	3	,	,	PUNCT
gs-4321	827	4	20(1	20(1	NUM
gs-4321	827	5	)	)	PUNCT
gs-4321	827	6	,	,	PUNCT
gs-4321	827	7	110	110	NUM
gs-4321	827	8	.	.	PUNCT
gs-4321	828	1	georgian	georgian	NOUN
gs-4321	828	2	scientists/	scientists/	NUM
gs-4321	828	3	.	.	PUNCT
gs-4321	829	1	7	7	NUM
gs-4321	829	2	n	n	DET
gs-4321	829	3	4	4	NUM
gs-4321	829	4	,	,	PUNCT
gs-4321	829	5	2025	2025	NUM
gs-4321	829	6	381	381	NUM
gs-4321	829	7	jensen	jensen	PROPN
gs-4321	829	8	,	,	PUNCT
gs-4321	829	9	c.	c.	PROPN
gs-4321	829	10	,	,	PUNCT
gs-4321	829	11	madsen	madsen	PROPN
gs-4321	829	12	,	,	PUNCT
gs-4321	829	13	d.	d.	PROPN
gs-4321	829	14	h.	h.	PROPN
gs-4321	829	15	,	,	PUNCT
gs-4321	829	16	hansen	hansen	PROPN
gs-4321	829	17	,	,	PUNCT
gs-4321	829	18	m.(2021	m.(2021	PROPN
gs-4321	829	19	)	)	PUNCT
gs-4321	829	20	.	.	PUNCT
gs-4321	830	1	non	non	ADJ
gs-4321	830	2	-	-	ADJ
gs-4321	830	3	invasive	invasive	ADJ
gs-4321	830	4	biomarkers	biomarker	NOUN
gs-4321	830	5	derived	derive	VERB
gs-4321	830	6	from	from	ADP
gs-4321	830	7	the	the	DET
gs-4321	830	8	extracellular	extracellular	ADJ
gs-4321	830	9	matrix	matrix	NOUN
gs-4321	830	10	associate	associate	NOUN
gs-4321	830	11	with	with	ADP
gs-4321	830	12	response	response	NOUN
gs-4321	830	13	to	to	ADP
gs-4321	830	14	immune	immune	ADJ
gs-4321	830	15	checkpoint	checkpoint	NOUN
gs-4321	830	16	blockade	blockade	NOUN
gs-4321	830	17	(	(	PUNCT
gs-4321	830	18	anti	anti	ADJ
gs-4321	830	19	-	-	NOUN
gs-4321	830	20	ctla-4	ctla-4	NOUN
gs-4321	830	21	)	)	PUNCT
gs-4321	830	22	in	in	ADP
gs-4321	830	23	metastatic	metastatic	ADJ
gs-4321	830	24	melanoma	melanoma	NOUN
gs-4321	830	25	patients	patient	NOUN
gs-4321	830	26	.	.	PUNCT
gs-4321	831	1	journal	journal	NOUN
gs-4321	831	2	for	for	ADP
gs-4321	831	3	immunotherapy	immunotherapy	NOUN
gs-4321	831	4	of	of	ADP
gs-4321	831	5	cancer	cancer	NOUN
gs-4321	831	6	,	,	PUNCT
gs-4321	831	7	6(1	6(1	NUM
gs-4321	831	8	)	)	PUNCT
gs-4321	831	9	,	,	PUNCT
gs-4321	831	10	152	152	NUM
gs-4321	831	11	.	.	PUNCT
gs-4321	832	1	jerby	jerby	NOUN
gs-4321	832	2	-	-	PUNCT
gs-4321	832	3	arnon	arnon	PROPN
gs-4321	832	4	,	,	PUNCT
gs-4321	832	5	l.	l.	PROPN
gs-4321	832	6	,	,	PUNCT
gs-4321	832	7	shah	shah	NOUN
gs-4321	832	8	,	,	PUNCT
gs-4321	832	9	p.	p.	NOUN
gs-4321	832	10	,	,	PUNCT
gs-4321	832	11	cuoco	cuoco	PROPN
gs-4321	832	12	,	,	PUNCT
gs-4321	832	13	m.	m.	NOUN
gs-4321	832	14	s.	s.	PROPN
gs-4321	832	15	,	,	PUNCT
gs-4321	832	16	rodman	rodman	PROPN
gs-4321	832	17	,	,	PUNCT
gs-4321	832	18	c.	c.	NOUN
gs-4321	832	19	(	(	PUNCT
gs-4321	832	20	2018	2018	NUM
gs-4321	832	21	)	)	PUNCT
gs-4321	832	22	.	.	PUNCT
gs-4321	833	1	a	a	DET
gs-4321	833	2	cancer	cancer	NOUN
gs-4321	833	3	cell	cell	NOUN
gs-4321	833	4	program	program	NOUN
gs-4321	833	5	promotes	promote	VERB
gs-4321	833	6	t	t	NOUN
gs-4321	833	7	cell	cell	NOUN
gs-4321	833	8	exclusion	exclusion	NOUN
gs-4321	833	9	and	and	CCONJ
gs-4321	833	10	resistance	resistance	NOUN
gs-4321	833	11	to	to	ADP
gs-4321	833	12	checkpoint	checkpoint	NOUN
gs-4321	833	13	blockade	blockade	NOUN
gs-4321	833	14	.	.	PUNCT
gs-4321	834	1	cell	cell	NOUN
gs-4321	834	2	,	,	PUNCT
gs-4321	834	3	175(4	175(4	NUM
gs-4321	834	4	)	)	PUNCT
gs-4321	834	5	,	,	PUNCT
gs-4321	834	6	984	984	NUM
gs-4321	834	7	–	–	PUNCT
gs-4321	834	8	997.e24	997.e24	NUM
gs-4321	834	9	.	.	PUNCT
gs-4321	834	10	kalluri	kalluri	PROPN
gs-4321	834	11	,	,	PUNCT
gs-4321	834	12	r.	r.	PROPN
gs-4321	834	13	(	(	PUNCT
gs-4321	834	14	2016	2016	NUM
gs-4321	834	15	)	)	PUNCT
gs-4321	834	16	.	.	PUNCT
gs-4321	835	1	the	the	DET
gs-4321	835	2	biology	biology	NOUN
gs-4321	835	3	and	and	CCONJ
gs-4321	835	4	function	function	NOUN
gs-4321	835	5	of	of	ADP
gs-4321	835	6	fibroblasts	fibroblast	NOUN
gs-4321	835	7	in	in	ADP
gs-4321	835	8	cancer	cancer	NOUN
gs-4321	835	9	.	.	PUNCT
gs-4321	836	1	nature	nature	NOUN
gs-4321	836	2	reviews	review	VERB
gs-4321	836	3	cancer	cancer	NOUN
gs-4321	836	4	,	,	PUNCT
gs-4321	836	5	16(9	16(9	NUM
gs-4321	836	6	)	)	PUNCT
gs-4321	836	7	,	,	PUNCT
gs-4321	836	8	582–598	582–598	NUM
gs-4321	836	9	.	.	PUNCT
gs-4321	837	1	kim	kim	PROPN
gs-4321	837	2	,	,	PUNCT
gs-4321	837	3	n.	n.	PROPN
gs-4321	837	4	,	,	PUNCT
gs-4321	837	5	kim	kim	PROPN
gs-4321	837	6	,	,	PUNCT
gs-4321	837	7	h.	h.	PROPN
gs-4321	837	8	k.	k.	PROPN
gs-4321	837	9	,	,	PUNCT
gs-4321	837	10	lee	lee	PROPN
gs-4321	837	11	,	,	PUNCT
gs-4321	837	12	k.	k.	PROPN
gs-4321	837	13	,	,	PUNCT
gs-4321	837	14	hong	hong	PROPN
gs-4321	837	15	,	,	PUNCT
gs-4321	837	16	y.	y.	PROPN
gs-4321	837	17	(	(	PUNCT
gs-4321	837	18	2020	2020	NUM
gs-4321	837	19	)	)	PUNCT
gs-4321	837	20	.	.	PUNCT
gs-4321	838	1	single	single	ADJ
gs-4321	838	2	-	-	PUNCT
gs-4321	838	3	cell	cell	NOUN
gs-4321	838	4	rna	rna	NOUN
gs-4321	838	5	sequencing	sequencing	NOUN
gs-4321	838	6	demonstrates	demonstrate	VERB
gs-4321	838	7	the	the	DET
gs-4321	838	8	molecular	molecular	ADJ
gs-4321	838	9	and	and	CCONJ
gs-4321	838	10	cellular	cellular	ADJ
gs-4321	838	11	reprogramming	reprogramming	NOUN
gs-4321	838	12	of	of	ADP
gs-4321	838	13	metastatic	metastatic	ADJ
gs-4321	838	14	lung	lung	NOUN
gs-4321	838	15	adenocarcinoma	adenocarcinoma	NOUN
gs-4321	838	16	.	.	PUNCT
gs-4321	839	1	nature	nature	NOUN
gs-4321	839	2	communications	communication	NOUN
gs-4321	839	3	,	,	PUNCT
gs-4321	839	4	11(1	11(1	NUM
gs-4321	839	5	)	)	PUNCT
gs-4321	839	6	,	,	PUNCT
gs-4321	839	7	2285	2285	NUM
gs-4321	839	8	.	.	PUNCT
gs-4321	840	1	kumar	kumar	PROPN
gs-4321	840	2	,	,	PUNCT
gs-4321	840	3	m.	m.	PROPN
gs-4321	840	4	p.	p.	PROPN
gs-4321	840	5	,	,	PUNCT
gs-4321	840	6	du	du	PROPN
gs-4321	840	7	,	,	PUNCT
gs-4321	840	8	j.	j.	PROPN
gs-4321	840	9	,	,	PUNCT
gs-4321	840	10	lagoudas	lagoudas	PROPN
gs-4321	840	11	,	,	PUNCT
gs-4321	840	12	g.	g.	PROPN
gs-4321	840	13	,	,	PUNCT
gs-4321	840	14	jiao	jiao	PROPN
gs-4321	840	15	,	,	PUNCT
gs-4321	840	16	y.	y.	PROPN
gs-4321	840	17	,	,	PUNCT
gs-4321	840	18	sawyer	sawyer	PROPN
gs-4321	840	19	,	,	PUNCT
gs-4321	840	20	a.	a.	PROPN
gs-4321	840	21	,	,	PUNCT
gs-4321	840	22	drummond	drummond	PROPN
gs-4321	840	23	,	,	PUNCT
gs-4321	840	24	d.	d.	PROPN
gs-4321	840	25	c.	c.	PROPN
gs-4321	840	26	,	,	PUNCT
gs-4321	840	27	lauffenburger	lauffenburger	PROPN
gs-4321	840	28	,	,	PUNCT
gs-4321	840	29	d.	d.	PROPN
gs-4321	840	30	a.	a.	PROPN
gs-4321	840	31	,	,	PUNCT
gs-4321	840	32	&	&	CCONJ
gs-4321	840	33	raue	raue	PROPN
gs-4321	840	34	,	,	PUNCT
gs-4321	840	35	a.	a.	NOUN
gs-4321	840	36	(	(	PUNCT
gs-4321	840	37	2018	2018	NUM
gs-4321	840	38	)	)	PUNCT
gs-4321	840	39	.	.	PUNCT
gs-4321	841	1	analysis	analysis	NOUN
gs-4321	841	2	of	of	ADP
gs-4321	841	3	single	single	ADJ
gs-4321	841	4	-	-	PUNCT
gs-4321	841	5	cell	cell	NOUN
gs-4321	841	6	rna	rna	NOUN
gs-4321	841	7	-	-	PUNCT
gs-4321	841	8	seq	seq	NOUN
gs-4321	841	9	identifies	identify	VERB
gs-4321	841	10	cell	cell	NOUN
gs-4321	841	11	-	-	PUNCT
gs-4321	841	12	cell	cell	NOUN
gs-4321	841	13	communication	communication	NOUN
gs-4321	841	14	associated	associate	VERB
gs-4321	841	15	with	with	ADP
gs-4321	841	16	tumor	tumor	NOUN
gs-4321	841	17	characteristics	characteristic	NOUN
gs-4321	841	18	.	.	PUNCT
gs-4321	842	1	cell	cell	NOUN
gs-4321	842	2	reports	report	NOUN
gs-4321	842	3	,	,	PUNCT
gs-4321	842	4	25(6	25(6	NOUN
gs-4321	842	5	)	)	PUNCT
gs-4321	842	6	,	,	PUNCT
gs-4321	842	7	1458–1468.e4	1458–1468.e4	NUM
gs-4321	842	8	.	.	PUNCT
gs-4321	843	1	la	la	PROPN
gs-4321	843	2	manno	manno	PROPN
gs-4321	843	3	,	,	PUNCT
gs-4321	843	4	g.	g.	PROPN
gs-4321	843	5	,	,	PUNCT
gs-4321	843	6	soldatov	soldatov	PROPN
gs-4321	843	7	,	,	PUNCT
gs-4321	843	8	r.	r.	PROPN
gs-4321	843	9	,	,	PUNCT
gs-4321	843	10	zeisel	zeisel	NOUN
gs-4321	843	11	,	,	PUNCT
gs-4321	843	12	a.(2018	a.(2018	PROPN
gs-4321	843	13	)	)	PUNCT
gs-4321	843	14	.	.	PUNCT
gs-4321	844	1	rna	rna	NOUN
gs-4321	844	2	velocity	velocity	NOUN
gs-4321	844	3	of	of	ADP
gs-4321	844	4	single	single	ADJ
gs-4321	844	5	cells	cell	NOUN
gs-4321	844	6	.	.	PUNCT
gs-4321	845	1	nature	nature	NOUN
gs-4321	845	2	,	,	PUNCT
gs-4321	845	3	560(7719	560(7719	NUM
gs-4321	845	4	)	)	PUNCT
gs-4321	845	5	,	,	PUNCT
gs-4321	845	6	494–498	494–498	PROPN
gs-4321	845	7	.	.	PUNCT
gs-4321	846	1	lamouille	lamouille	PROPN
gs-4321	846	2	,	,	PUNCT
gs-4321	846	3	s.	s.	PROPN
gs-4321	846	4	,	,	PUNCT
gs-4321	846	5	xu	xu	PROPN
gs-4321	846	6	,	,	PUNCT
gs-4321	846	7	j.	j.	PROPN
gs-4321	846	8	,	,	PUNCT
gs-4321	846	9	&	&	CCONJ
gs-4321	846	10	derynck	derynck	PROPN
gs-4321	846	11	,	,	PUNCT
gs-4321	846	12	r.	r.	PROPN
gs-4321	846	13	(	(	PUNCT
gs-4321	846	14	2014	2014	NUM
gs-4321	846	15	)	)	PUNCT
gs-4321	846	16	.	.	PUNCT
gs-4321	847	1	molecular	molecular	ADJ
gs-4321	847	2	mechanisms	mechanism	NOUN
gs-4321	847	3	of	of	ADP
gs-4321	847	4	epithelial	epithelial	ADJ
gs-4321	847	5	–	–	PUNCT
gs-4321	847	6	mesenchymal	mesenchymal	ADJ
gs-4321	847	7	transition	transition	NOUN
gs-4321	847	8	.	.	PUNCT
gs-4321	848	1	nature	nature	NOUN
gs-4321	848	2	reviews	review	VERB
gs-4321	848	3	molecular	molecular	ADJ
gs-4321	848	4	cell	cell	NOUN
gs-4321	848	5	biology	biology	NOUN
gs-4321	848	6	,	,	PUNCT
gs-4321	848	7	15(3	15(3	NUM
gs-4321	848	8	)	)	PUNCT
gs-4321	848	9	,	,	PUNCT
gs-4321	848	10	178–196	178–196	NUM
gs-4321	848	11	.	.	PUNCT
gs-4321	849	1	lee	lee	PROPN
gs-4321	849	2	,	,	PUNCT
gs-4321	849	3	h.	h.	PROPN
gs-4321	849	4	o.	o.	PROPN
gs-4321	849	5	,	,	PUNCT
gs-4321	849	6	hong	hong	PROPN
gs-4321	849	7	,	,	PUNCT
gs-4321	849	8	y.	y.	PROPN
gs-4321	849	9	,	,	PUNCT
gs-4321	849	10	etlioglu	etlioglu	PROPN
gs-4321	849	11	,	,	PUNCT
gs-4321	849	12	h.	h.	PROPN
gs-4321	849	13	e.	e.	PROPN
gs-4321	849	14	(	(	PUNCT
gs-4321	849	15	2020	2020	NUM
gs-4321	849	16	)	)	PUNCT
gs-4321	849	17	.	.	PUNCT
gs-4321	850	1	lineage	lineage	NOUN
gs-4321	850	2	-	-	PUNCT
gs-4321	850	3	dependent	dependent	ADJ
gs-4321	850	4	gene	gene	NOUN
gs-4321	850	5	expression	expression	NOUN
gs-4321	850	6	programs	program	NOUN
gs-4321	850	7	influence	influence	VERB
gs-4321	850	8	the	the	DET
gs-4321	850	9	immune	immune	ADJ
gs-4321	850	10	landscape	landscape	NOUN
gs-4321	850	11	of	of	ADP
gs-4321	850	12	colorectal	colorectal	ADJ
gs-4321	850	13	cancer	cancer	NOUN
gs-4321	850	14	.	.	PUNCT
gs-4321	851	1	nature	nature	NOUN
gs-4321	851	2	genetics	genetic	NOUN
gs-4321	851	3	,	,	PUNCT
gs-4321	851	4	52(6	52(6	NOUN
gs-4321	851	5	)	)	PUNCT
gs-4321	851	6	,	,	PUNCT
gs-4321	851	7	594–603	594–603	NUM
gs-4321	851	8	.	.	PUNCT
gs-4321	851	9	liau	liau	PROPN
gs-4321	851	10	,	,	PUNCT
gs-4321	851	11	b.	b.	PROPN
gs-4321	851	12	b.	b.	PROPN
gs-4321	851	13	,	,	PUNCT
gs-4321	851	14	sievers	sievers	PROPN
gs-4321	851	15	,	,	PUNCT
gs-4321	851	16	c.	c.	PROPN
gs-4321	851	17	,	,	PUNCT
gs-4321	851	18	donohue	donohue	PROPN
gs-4321	851	19	,	,	PUNCT
gs-4321	851	20	l.	l.	PROPN
gs-4321	851	21	k.	k.	PROPN
gs-4321	851	22	(	(	PUNCT
gs-4321	851	23	2017	2017	NUM
gs-4321	851	24	)	)	PUNCT
gs-4321	851	25	.	.	PUNCT
gs-4321	852	1	adaptive	adaptive	ADJ
gs-4321	852	2	chromatin	chromatin	NOUN
gs-4321	852	3	remodeling	remodeling	NOUN
gs-4321	852	4	drives	drive	NOUN
gs-4321	852	5	glioblastoma	glioblastoma	NOUN
gs-4321	852	6	stem	stem	NOUN
gs-4321	852	7	cell	cell	NOUN
gs-4321	852	8	plasticity	plasticity	NOUN
gs-4321	852	9	and	and	CCONJ
gs-4321	852	10	drug	drug	NOUN
gs-4321	852	11	tolerance	tolerance	NOUN
gs-4321	852	12	.	.	PUNCT
gs-4321	853	1	cell	cell	NOUN
gs-4321	853	2	stem	stem	NOUN
gs-4321	853	3	cell	cell	NOUN
gs-4321	853	4	,	,	PUNCT
gs-4321	853	5	20(2	20(2	NUM
gs-4321	853	6	)	)	PUNCT
gs-4321	853	7	,	,	PUNCT
gs-4321	853	8	233	233	NUM
gs-4321	853	9	–	–	PUNCT
gs-4321	853	10	246.e7	246.e7	NUM
gs-4321	853	11	.	.	PUNCT
gs-4321	854	1	lotfollahi	lotfollahi	PROPN
gs-4321	854	2	,	,	PUNCT
gs-4321	854	3	m.	m.	NOUN
gs-4321	854	4	,	,	PUNCT
gs-4321	854	5	wolf	wolf	PROPN
gs-4321	854	6	,	,	PUNCT
gs-4321	854	7	f.	f.	PROPN
gs-4321	854	8	a.	a.	PROPN
gs-4321	854	9	,	,	PUNCT
gs-4321	854	10	&	&	CCONJ
gs-4321	854	11	theis	theis	PROPN
gs-4321	854	12	,	,	PUNCT
gs-4321	854	13	f.	f.	PROPN
gs-4321	854	14	j.	j.	PROPN
gs-4321	854	15	(	(	PUNCT
gs-4321	854	16	2019	2019	NUM
gs-4321	854	17	)	)	PUNCT
gs-4321	854	18	.	.	PUNCT
gs-4321	855	1	scgen	scgen	PROPN
gs-4321	855	2	predicts	predict	VERB
gs-4321	855	3	single	single	ADJ
gs-4321	855	4	-	-	PUNCT
gs-4321	855	5	cell	cell	NOUN
gs-4321	855	6	perturbation	perturbation	NOUN
gs-4321	855	7	responses	response	NOUN
gs-4321	855	8	.	.	PUNCT
gs-4321	856	1	nature	nature	NOUN
gs-4321	856	2	methods	method	NOUN
gs-4321	856	3	,	,	PUNCT
gs-4321	856	4	16(8	16(8	NUM
gs-4321	856	5	)	)	PUNCT
gs-4321	856	6	,	,	PUNCT
gs-4321	856	7	715–721	715–721	NUM
gs-4321	856	8	.	.	PUNCT
gs-4321	857	1	ma	ma	PROPN
gs-4321	857	2	,	,	PUNCT
gs-4321	857	3	s.	s.	PROPN
gs-4321	857	4	,	,	PUNCT
gs-4321	857	5	zhang	zhang	PROPN
gs-4321	857	6	,	,	PUNCT
gs-4321	857	7	b.	b.	PROPN
gs-4321	857	8	,	,	PUNCT
gs-4321	857	9	lafave	lafave	PROPN
gs-4321	857	10	,	,	PUNCT
gs-4321	857	11	l.	l.	PROPN
gs-4321	857	12	m.	m.	PROPN
gs-4321	857	13	,	,	PUNCT
gs-4321	857	14	earl	earl	PROPN
gs-4321	857	15	,	,	PUNCT
gs-4321	857	16	a.	a.	NOUN
gs-4321	857	17	s.(2020	s.(2020	PROPN
gs-4321	857	18	)	)	PUNCT
gs-4321	857	19	.	.	PUNCT
gs-4321	858	1	chromatin	chromatin	NOUN
gs-4321	858	2	potential	potential	NOUN
gs-4321	858	3	identified	identify	VERB
gs-4321	858	4	by	by	ADP
gs-4321	858	5	shared	share	VERB
gs-4321	858	6	single	single	ADJ
gs-4321	858	7	-	-	PUNCT
gs-4321	858	8	cell	cell	NOUN
gs-4321	858	9	profiling	profiling	NOUN
gs-4321	858	10	of	of	ADP
gs-4321	858	11	rna	rna	NOUN
gs-4321	858	12	and	and	CCONJ
gs-4321	858	13	chromatin	chromatin	NOUN
gs-4321	858	14	.	.	PUNCT
gs-4321	859	1	cell	cell	NOUN
gs-4321	859	2	,	,	PUNCT
gs-4321	859	3	183(4	183(4	NUM
gs-4321	859	4	)	)	PUNCT
gs-4321	859	5	,	,	PUNCT
gs-4321	859	6	1103–1116.e20	1103–1116.e20	NUM
gs-4321	859	7	.	.	PUNCT
gs-4321	860	1	marjanovic	marjanovic	NOUN
gs-4321	860	2	,	,	PUNCT
gs-4321	860	3	n.	n.	PROPN
gs-4321	860	4	d.	d.	PROPN
gs-4321	860	5	,	,	PUNCT
gs-4321	860	6	hofree	hofree	NOUN
gs-4321	860	7	,	,	PUNCT
gs-4321	860	8	m.	m.	NOUN
gs-4321	860	9	,	,	PUNCT
gs-4321	860	10	chan	chan	PROPN
gs-4321	860	11	,	,	PUNCT
gs-4321	860	12	j.	j.	PROPN
gs-4321	860	13	e.	e.	PROPN
gs-4321	860	14	(	(	PUNCT
gs-4321	860	15	2020	2020	NUM
gs-4321	860	16	)	)	PUNCT
gs-4321	860	17	.	.	PUNCT
gs-4321	861	1	emergence	emergence	NOUN
gs-4321	861	2	of	of	ADP
gs-4321	861	3	a	a	DET
gs-4321	861	4	high	high	ADJ
gs-4321	861	5	-	-	PUNCT
gs-4321	861	6	plasticity	plasticity	NOUN
gs-4321	861	7	cell	cell	NOUN
gs-4321	861	8	state	state	NOUN
gs-4321	861	9	during	during	ADP
gs-4321	861	10	lung	lung	NOUN
gs-4321	861	11	cancer	cancer	NOUN
gs-4321	861	12	evolution	evolution	NOUN
gs-4321	861	13	.	.	PUNCT
gs-4321	862	1	cancer	cancer	NOUN
gs-4321	862	2	cell	cell	NOUN
gs-4321	862	3	,	,	PUNCT
gs-4321	862	4	38(2	38(2	NOUN
gs-4321	862	5	)	)	PUNCT
gs-4321	862	6	,	,	PUNCT
gs-4321	862	7	229–246.e13	229–246.e13	PROPN
gs-4321	862	8	.	.	PUNCT
gs-4321	863	1	meacham	meacham	PROPN
gs-4321	863	2	,	,	PUNCT
gs-4321	863	3	c.	c.	PROPN
gs-4321	863	4	e.	e.	PROPN
gs-4321	863	5	,	,	PUNCT
gs-4321	863	6	&	&	CCONJ
gs-4321	863	7	morrison	morrison	PROPN
gs-4321	863	8	,	,	PUNCT
gs-4321	863	9	s.	s.	PROPN
gs-4321	863	10	j.	j.	PROPN
gs-4321	863	11	(	(	PUNCT
gs-4321	863	12	2013	2013	NUM
gs-4321	863	13	)	)	PUNCT
gs-4321	863	14	.	.	PUNCT
gs-4321	864	1	tumour	tumour	ADJ
gs-4321	864	2	heterogeneity	heterogeneity	NOUN
gs-4321	864	3	and	and	CCONJ
gs-4321	864	4	cancer	cancer	NOUN
gs-4321	864	5	cell	cell	NOUN
gs-4321	864	6	plasticity	plasticity	NOUN
gs-4321	864	7	.	.	PUNCT
gs-4321	865	1	nature	nature	PROPN
gs-4321	865	2	,	,	PUNCT
gs-4321	865	3	501(7467	501(7467	NUM
gs-4321	865	4	)	)	PUNCT
gs-4321	865	5	,	,	PUNCT
gs-4321	865	6	328–337	328–337	NUM
gs-4321	865	7	.	.	PUNCT
gs-4321	866	1	neftel	neftel	NOUN
gs-4321	866	2	,	,	PUNCT
gs-4321	866	3	c.	c.	PROPN
gs-4321	866	4	,	,	PUNCT
gs-4321	866	5	laffy	laffy	PROPN
gs-4321	866	6	,	,	PUNCT
gs-4321	866	7	j.	j.	PROPN
gs-4321	866	8	,	,	PUNCT
gs-4321	866	9	filbin	filbin	NOUN
gs-4321	866	10	,	,	PUNCT
gs-4321	866	11	m.	m.	NOUN
gs-4321	866	12	g.	g.	PROPN
gs-4321	866	13	,	,	PUNCT
gs-4321	866	14	hara	hara	PROPN
gs-4321	866	15	.	.	PUNCT
gs-4321	867	1	(	(	PUNCT
gs-4321	867	2	2019	2019	NUM
gs-4321	867	3	)	)	PUNCT
gs-4321	867	4	.	.	PUNCT
gs-4321	868	1	an	an	DET
gs-4321	868	2	integrative	integrative	ADJ
gs-4321	868	3	model	model	NOUN
gs-4321	868	4	of	of	ADP
gs-4321	868	5	cellular	cellular	ADJ
gs-4321	868	6	states	state	NOUN
gs-4321	868	7	,	,	PUNCT
gs-4321	868	8	plasticity	plasticity	NOUN
gs-4321	868	9	,	,	PUNCT
gs-4321	868	10	and	and	CCONJ
gs-4321	868	11	genetics	genetic	NOUN
gs-4321	868	12	for	for	ADP
gs-4321	868	13	glioblastoma	glioblastoma	NOUN
gs-4321	868	14	.	.	PUNCT
gs-4321	869	1	cell	cell	NOUN
gs-4321	869	2	,	,	PUNCT
gs-4321	869	3	178(4	178(4	NUM
gs-4321	869	4	)	)	PUNCT
gs-4321	869	5	,	,	PUNCT
gs-4321	869	6	835–849.e21	835–849.e21	NUM
gs-4321	869	7	.	.	PUNCT
gs-4321	870	1	nguyen	nguyen	NOUN
gs-4321	870	2	,	,	PUNCT
gs-4321	871	1	p.	p.	PROPN
gs-4321	871	2	h.	h.	PROPN
gs-4321	871	3	d.	d.	PROPN
gs-4321	871	4	,	,	PUNCT
gs-4321	871	5	ma	ma	PROPN
gs-4321	871	6	,	,	PUNCT
gs-4321	871	7	s.	s.	PROPN
gs-4321	871	8	,	,	PUNCT
gs-4321	871	9	phua	phua	PROPN
gs-4321	871	10	,	,	PUNCT
gs-4321	871	11	c.	c.	PROPN
gs-4321	871	12	z.	z.	PROPN
gs-4321	871	13	j.	j.	PROPN
gs-4321	871	14	,	,	PUNCT
gs-4321	871	15	kaya	kaya	PROPN
gs-4321	871	16	.	.	PROPN
gs-4321	871	17	(	(	PUNCT
gs-4321	871	18	2020	2020	NUM
gs-4321	871	19	)	)	PUNCT
gs-4321	871	20	.	.	PUNCT
gs-4321	872	1	intratumoural	intratumoural	ADJ
gs-4321	872	2	immune	immune	ADJ
gs-4321	872	3	heterogeneity	heterogeneity	NOUN
gs-4321	872	4	as	as	ADP
gs-4321	872	5	a	a	DET
gs-4321	872	6	hallmark	hallmark	NOUN
gs-4321	872	7	of	of	ADP
gs-4321	872	8	tumour	tumour	NOUN
gs-4321	872	9	evolution	evolution	NOUN
gs-4321	872	10	and	and	CCONJ
gs-4321	872	11	progression	progression	NOUN
gs-4321	872	12	in	in	ADP
gs-4321	872	13	hepatocellular	hepatocellular	ADJ
gs-4321	872	14	carcinoma	carcinoma	NOUN
gs-4321	872	15	.	.	PUNCT
gs-4321	873	1	nature	nature	NOUN
gs-4321	873	2	communications	communication	NOUN
gs-4321	873	3	,	,	PUNCT
gs-4321	873	4	11(1	11(1	NUM
gs-4321	873	5	)	)	PUNCT
gs-4321	873	6	,	,	PUNCT
gs-4321	873	7	227	227	NUM
gs-4321	873	8	.	.	PUNCT
gs-4321	874	1	georgian	georgian	NOUN
gs-4321	874	2	scientists/	scientists/	NUM
gs-4321	874	3	.	.	PUNCT
gs-4321	875	1	7	7	NUM
gs-4321	875	2	n	n	DET
gs-4321	875	3	4	4	NUM
gs-4321	875	4	,	,	PUNCT
gs-4321	875	5	2025	2025	NUM
gs-4321	875	6	382	382	NUM
gs-4321	875	7	o'donnell	o'donnell	PROPN
gs-4321	875	8	,	,	PUNCT
gs-4321	875	9	j.	j.	PROPN
gs-4321	875	10	s.	s.	PROPN
gs-4321	875	11	,	,	PUNCT
gs-4321	875	12	long	long	ADV
gs-4321	875	13	,	,	PUNCT
gs-4321	875	14	g.	g.	PROPN
gs-4321	875	15	v.	v.	PROPN
gs-4321	875	16	,	,	PUNCT
gs-4321	875	17	scolyer	scolyer	PROPN
gs-4321	875	18	,	,	PUNCT
gs-4321	875	19	r.	r.	PROPN
gs-4321	875	20	a.	a.	PROPN
gs-4321	875	21	,	,	PUNCT
gs-4321	875	22	teng	teng	PROPN
gs-4321	875	23	,	,	PUNCT
gs-4321	875	24	m.	m.	PROPN
gs-4321	875	25	w.	w.	PROPN
gs-4321	875	26	,	,	PUNCT
gs-4321	875	27	&	&	CCONJ
gs-4321	875	28	smyth	smyth	PROPN
gs-4321	875	29	,	,	PUNCT
gs-4321	875	30	m.	m.	NOUN
gs-4321	875	31	j.	j.	PROPN
gs-4321	875	32	(	(	PUNCT
gs-4321	875	33	2017	2017	NUM
gs-4321	875	34	)	)	PUNCT
gs-4321	875	35	.	.	PUNCT
gs-4321	876	1	resistance	resistance	NOUN
gs-4321	876	2	to	to	PART
gs-4321	876	3	pd1	pd1	VERB
gs-4321	876	4	/	/	SYM
gs-4321	876	5	pdl1	pdl1	NOUN
gs-4321	876	6	checkpoint	checkpoint	NOUN
gs-4321	876	7	inhibition	inhibition	NOUN
gs-4321	876	8	.	.	PUNCT
gs-4321	877	1	cancer	cancer	NOUN
gs-4321	877	2	treatment	treatment	NOUN
gs-4321	877	3	reviews	review	NOUN
gs-4321	877	4	,	,	PUNCT
gs-4321	877	5	52	52	NUM
gs-4321	877	6	,	,	PUNCT
gs-4321	877	7	71	71	NUM
gs-4321	877	8	–	–	SYM
gs-4321	877	9	81	81	NUM
gs-4321	877	10	.	.	PUNCT
gs-4321	878	1	ogden	ogden	PROPN
gs-4321	878	2	,	,	PUNCT
gs-4321	878	3	a.	a.	PROPN
gs-4321	878	4	,	,	PUNCT
gs-4321	878	5	garlapati	garlapati	PROPN
gs-4321	878	6	,	,	PUNCT
gs-4321	878	7	c.	c.	PROPN
gs-4321	878	8	,	,	PUNCT
gs-4321	878	9	li	li	PROPN
gs-4321	878	10	,	,	PUNCT
gs-4321	878	11	x.	x.	PROPN
gs-4321	878	12	b.	b.	PROPN
gs-4321	878	13	,	,	PUNCT
gs-4321	878	14	turaga	turaga	PROPN
gs-4321	878	15	,	,	PUNCT
gs-4321	878	16	r.	r.	PROPN
gs-4321	878	17	c.(2020	c.(2020	PROPN
gs-4321	878	18	)	)	PUNCT
gs-4321	878	19	.	.	PUNCT
gs-4321	879	1	multi	multi	ADJ
gs-4321	879	2	-	-	ADJ
gs-4321	879	3	institutional	institutional	ADJ
gs-4321	879	4	study	study	NOUN
gs-4321	879	5	of	of	ADP
gs-4321	879	6	nuclear	nuclear	ADJ
gs-4321	879	7	kifc1	kifc1	PROPN
gs-4321	879	8	as	as	ADP
gs-4321	879	9	a	a	DET
gs-4321	879	10	biomarker	biomarker	NOUN
gs-4321	879	11	of	of	ADP
gs-4321	879	12	poor	poor	ADJ
gs-4321	879	13	prognosis	prognosis	NOUN
gs-4321	879	14	in	in	ADP
gs-4321	879	15	african	african	ADJ
gs-4321	879	16	american	american	ADJ
gs-4321	879	17	women	woman	NOUN
gs-4321	879	18	with	with	ADP
gs-4321	879	19	triple	triple	ADJ
gs-4321	879	20	-	-	PUNCT
gs-4321	879	21	negative	negative	ADJ
gs-4321	879	22	breast	breast	NOUN
gs-4321	879	23	cancer	cancer	NOUN
gs-4321	879	24	.	.	PUNCT
gs-4321	880	1	scientific	scientific	ADJ
gs-4321	880	2	reports	report	NOUN
gs-4321	880	3	,	,	PUNCT
gs-4321	880	4	10(1	10(1	NUM
gs-4321	880	5	)	)	PUNCT
gs-4321	880	6	,	,	PUNCT
gs-4321	880	7	7944	7944	NUM
gs-4321	880	8	.	.	PUNCT
gs-4321	881	1	oren	oren	NOUN
gs-4321	881	2	,	,	PUNCT
gs-4321	881	3	y.	y.	PROPN
gs-4321	881	4	,	,	PUNCT
gs-4321	881	5	tsabar	tsabar	PROPN
gs-4321	881	6	,	,	PUNCT
gs-4321	881	7	m.	m.	NOUN
gs-4321	881	8	,	,	PUNCT
gs-4321	881	9	cuoco	cuoco	PROPN
gs-4321	881	10	,	,	PUNCT
gs-4321	881	11	m.	m.	NOUN
gs-4321	881	12	s.	s.	PROPN
gs-4321	881	13	,	,	PUNCT
gs-4321	881	14	amir	amir	PROPN
gs-4321	881	15	-	-	PROPN
gs-4321	881	16	zilberstein	zilberstein	PROPN
gs-4321	881	17	.	.	PUNCT
gs-4321	882	1	(	(	PUNCT
gs-4321	882	2	2021	2021	NUM
gs-4321	882	3	)	)	PUNCT
gs-4321	882	4	.	.	PUNCT
gs-4321	883	1	cycling	cycle	VERB
gs-4321	883	2	cancer	cancer	NOUN
gs-4321	883	3	persister	persister	NOUN
gs-4321	883	4	cells	cell	NOUN
gs-4321	883	5	arise	arise	VERB
gs-4321	883	6	from	from	ADP
gs-4321	883	7	lineages	lineage	NOUN
gs-4321	883	8	with	with	ADP
gs-4321	883	9	distinct	distinct	ADJ
gs-4321	883	10	programs	program	NOUN
gs-4321	883	11	.	.	PUNCT
gs-4321	884	1	nature	nature	NOUN
gs-4321	884	2	,	,	PUNCT
gs-4321	884	3	596(7873	596(7873	NUM
gs-4321	884	4	)	)	PUNCT
gs-4321	884	5	,	,	PUNCT
gs-4321	884	6	576	576	NUM
gs-4321	884	7	–	–	PUNCT
gs-4321	884	8	582	582	NUM
gs-4321	884	9	.	.	PUNCT
gs-4321	885	1	pastushenko	pastushenko	PROPN
gs-4321	885	2	,	,	PUNCT
gs-4321	885	3	i.	i.	PROPN
gs-4321	885	4	,	,	PUNCT
gs-4321	885	5	brisebarre	brisebarre	PROPN
gs-4321	885	6	,	,	PUNCT
gs-4321	885	7	a.	a.	NOUN
gs-4321	885	8	,	,	PUNCT
gs-4321	885	9	sifrim	sifrim	NOUN
gs-4321	885	10	,	,	PUNCT
gs-4321	885	11	a.	a.	NOUN
gs-4321	885	12	,	,	PUNCT
gs-4321	885	13	(	(	PUNCT
gs-4321	885	14	2018	2018	NUM
gs-4321	885	15	)	)	PUNCT
gs-4321	885	16	.	.	PUNCT
gs-4321	886	1	identification	identification	NOUN
gs-4321	886	2	of	of	ADP
gs-4321	886	3	the	the	DET
gs-4321	886	4	tumour	tumour	NOUN
gs-4321	886	5	transition	transition	NOUN
gs-4321	886	6	states	state	NOUN
gs-4321	886	7	occurring	occur	VERB
gs-4321	886	8	during	during	ADP
gs-4321	886	9	emt	emt	PROPN
gs-4321	886	10	.	.	PUNCT
gs-4321	886	11	nature	nature	PROPN
gs-4321	886	12	,	,	PUNCT
gs-4321	886	13	556(7702	556(7702	NUM
gs-4321	886	14	)	)	PUNCT
gs-4321	886	15	,	,	PUNCT
gs-4321	886	16	463–468	463–468	NUM
gs-4321	886	17	.	.	PUNCT
gs-4321	887	1	pérez	pérez	NOUN
gs-4321	887	2	-	-	PUNCT
gs-4321	887	3	garcía	garcía	ADJ
gs-4321	887	4	,	,	PUNCT
gs-4321	887	5	a.	a.	NOUN
gs-4321	887	6	,	,	PUNCT
gs-4321	887	7	pérez	pérez	NOUN
gs-4321	887	8	-	-	PUNCT
gs-4321	887	9	jannotti	jannotti	NOUN
gs-4321	887	10	,	,	PUNCT
gs-4321	887	11	g.	g.	PROPN
gs-4321	887	12	,	,	PUNCT
gs-4321	887	13	sánchez	sánchez	NOUN
gs-4321	887	14	-	-	PUNCT
gs-4321	887	15	céspedes	céspede	NOUN
gs-4321	887	16	,	,	PUNCT
gs-4321	887	17	r.	r.	NOUN
gs-4321	887	18	(	(	PUNCT
gs-4321	887	19	2022	2022	NUM
gs-4321	887	20	)	)	PUNCT
gs-4321	887	21	.	.	PUNCT
gs-4321	888	1	epigenetic	epigenetic	ADJ
gs-4321	888	2	mechanisms	mechanism	NOUN
gs-4321	888	3	in	in	ADP
gs-4321	888	4	breast	breast	NOUN
gs-4321	888	5	cancer	cancer	NOUN
gs-4321	888	6	therapy	therapy	NOUN
gs-4321	888	7	and	and	CCONJ
gs-4321	888	8	resistance	resistance	NOUN
gs-4321	888	9	.	.	PUNCT
gs-4321	889	1	international	international	ADJ
gs-4321	889	2	journal	journal	NOUN
gs-4321	889	3	of	of	ADP
gs-4321	889	4	molecular	molecular	ADJ
gs-4321	889	5	sciences	science	NOUN
gs-4321	889	6	,	,	PUNCT
gs-4321	889	7	23(7	23(7	NUM
gs-4321	889	8	)	)	PUNCT
gs-4321	889	9	,	,	PUNCT
gs-4321	889	10	3721	3721	NUM
gs-4321	889	11	.	.	PUNCT
gs-4321	890	1	rambow	rambow	PROPN
gs-4321	890	2	,	,	PUNCT
gs-4321	890	3	f.	f.	PROPN
gs-4321	890	4	,	,	PUNCT
gs-4321	890	5	rogiers	rogier	NOUN
gs-4321	890	6	,	,	PUNCT
gs-4321	890	7	a.	a.	NOUN
gs-4321	890	8	,	,	PUNCT
gs-4321	890	9	marin	marin	NOUN
gs-4321	890	10	-	-	PUNCT
gs-4321	890	11	bejar	bejar	NOUN
gs-4321	890	12	,	,	PUNCT
gs-4321	890	13	o.	o.	NOUN
gs-4321	890	14	,	,	PUNCT
gs-4321	890	15	aibar	aibar	PROPN
gs-4321	890	16	,	,	PUNCT
gs-4321	890	17	s.	s.	PROPN
gs-4321	890	18	(	(	PUNCT
gs-4321	890	19	2018	2018	NUM
gs-4321	890	20	)	)	PUNCT
gs-4321	890	21	.	.	PUNCT
gs-4321	891	1	toward	toward	ADP
gs-4321	891	2	minimal	minimal	ADJ
gs-4321	891	3	residual	residual	ADJ
gs-4321	891	4	disease	disease	NOUN
gs-4321	891	5	-	-	PUNCT
gs-4321	891	6	directed	direct	VERB
gs-4321	891	7	therapy	therapy	NOUN
gs-4321	891	8	in	in	ADP
gs-4321	891	9	melanoma	melanoma	NOUN
gs-4321	891	10	.	.	PUNCT
gs-4321	892	1	cell	cell	NOUN
gs-4321	892	2	,	,	PUNCT
gs-4321	892	3	174(4	174(4	NUM
gs-4321	892	4	)	)	PUNCT
gs-4321	892	5	,	,	PUNCT
gs-4321	892	6	843–855.e19	843–855.e19	NUM
gs-4321	892	7	.	.	PUNCT
gs-4321	893	1	reya	reya	PROPN
gs-4321	893	2	,	,	PUNCT
gs-4321	893	3	t.	t.	PROPN
gs-4321	893	4	,	,	PUNCT
gs-4321	893	5	&	&	CCONJ
gs-4321	893	6	clevers	clevers	PROPN
gs-4321	893	7	,	,	PUNCT
gs-4321	893	8	h.	h.	PROPN
gs-4321	893	9	(	(	PUNCT
gs-4321	893	10	2005	2005	NUM
gs-4321	893	11	)	)	PUNCT
gs-4321	893	12	.	.	PUNCT
gs-4321	894	1	wnt	wnt	NOUN
gs-4321	894	2	signalling	signal	VERB
gs-4321	894	3	in	in	ADP
gs-4321	894	4	stem	stem	NOUN
gs-4321	894	5	cells	cell	NOUN
gs-4321	894	6	and	and	CCONJ
gs-4321	894	7	cancer	cancer	NOUN
gs-4321	894	8	.	.	PUNCT
gs-4321	895	1	nature	nature	NOUN
gs-4321	895	2	,	,	PUNCT
gs-4321	895	3	434(7035	434(7035	NUM
gs-4321	895	4	)	)	PUNCT
gs-4321	895	5	,	,	PUNCT
gs-4321	895	6	843–850	843–850	NUM
gs-4321	895	7	.	.	PUNCT
gs-4321	896	1	rheinbay	rheinbay	PROPN
gs-4321	896	2	,	,	PUNCT
gs-4321	896	3	e.	e.	PROPN
gs-4321	896	4	,	,	PUNCT
gs-4321	896	5	nielsen	nielsen	PROPN
gs-4321	896	6	,	,	PUNCT
gs-4321	896	7	m.	m.	NOUN
gs-4321	896	8	m.	m.	NOUN
gs-4321	896	9	,	,	PUNCT
gs-4321	896	10	abascal	abascal	ADJ
gs-4321	896	11	,	,	PUNCT
gs-4321	896	12	f.	f.	PROPN
gs-4321	896	13	,	,	PUNCT
gs-4321	896	14	wala	wala	PROPN
gs-4321	896	15	,	,	PUNCT
gs-4321	896	16	j.	j.	PROPN
gs-4321	896	17	(	(	PUNCT
gs-4321	896	18	2020	2020	NUM
gs-4321	896	19	)	)	PUNCT
gs-4321	896	20	.	.	PUNCT
gs-4321	897	1	analyses	analysis	NOUN
gs-4321	897	2	of	of	ADP
gs-4321	897	3	non	non	ADJ
gs-4321	897	4	-	-	ADJ
gs-4321	897	5	coding	coding	ADJ
gs-4321	897	6	somatic	somatic	ADJ
gs-4321	897	7	drivers	driver	NOUN
gs-4321	897	8	in	in	ADP
gs-4321	897	9	2,658	2,658	NUM
gs-4321	897	10	cancer	cancer	NOUN
gs-4321	897	11	whole	whole	ADJ
gs-4321	897	12	genomes	genome	NOUN
gs-4321	897	13	.	.	PUNCT
gs-4321	898	1	nature	nature	NOUN
gs-4321	898	2	,	,	PUNCT
gs-4321	898	3	578(7793	578(7793	NUM
gs-4321	898	4	)	)	PUNCT
gs-4321	898	5	,	,	PUNCT
gs-4321	898	6	102–111	102–111	NUM
gs-4321	898	7	.	.	PUNCT
gs-4321	899	1	rodriques	rodrique	NOUN
gs-4321	899	2	,	,	PUNCT
gs-4321	899	3	s.	s.	PROPN
gs-4321	899	4	g.	g.	PROPN
gs-4321	899	5	,	,	PUNCT
gs-4321	899	6	stickels	stickels	PROPN
gs-4321	899	7	,	,	PUNCT
gs-4321	899	8	r.	r.	PROPN
gs-4321	899	9	r.	r.	PROPN
gs-4321	899	10	,	,	PUNCT
gs-4321	899	11	goeva	goeva	PROPN
gs-4321	899	12	,	,	PUNCT
gs-4321	899	13	a.	a.	PROPN
gs-4321	899	14	,	,	PUNCT
gs-4321	899	15	martin	martin	PROPN
gs-4321	899	16	,	,	PUNCT
gs-4321	899	17	c.	c.	PROPN
gs-4321	899	18	a.	a.	PROPN
gs-4321	899	19	,	,	PUNCT
gs-4321	899	20	murray	murray	PROPN
gs-4321	899	21	,	,	PUNCT
gs-4321	899	22	e.	e.	PROPN
gs-4321	899	23	,	,	PUNCT
gs-4321	899	24	vanderburg	vanderburg	NOUN
gs-4321	899	25	,	,	PUNCT
gs-4321	899	26	c.	c.	PROPN
gs-4321	899	27	r.	r.	PROPN
gs-4321	899	28	,	,	PUNCT
gs-4321	899	29	welch	welch	PROPN
gs-4321	899	30	,	,	PUNCT
gs-4321	899	31	j.	j.	PROPN
gs-4321	899	32	,	,	PUNCT
gs-4321	899	33	chen	chen	PROPN
gs-4321	899	34	,	,	PUNCT
gs-4321	899	35	l.	l.	PROPN
gs-4321	899	36	m.	m.	PROPN
gs-4321	899	37	,	,	PUNCT
gs-4321	899	38	chen	chen	PROPN
gs-4321	899	39	,	,	PUNCT
gs-4321	899	40	f.	f.	PROPN
gs-4321	899	41	,	,	PUNCT
gs-4321	899	42	&	&	CCONJ
gs-4321	899	43	macosko	macosko	PROPN
gs-4321	899	44	,	,	PUNCT
gs-4321	899	45	e.	e.	PROPN
gs-4321	899	46	z.	z.	PROPN
gs-4321	899	47	(	(	PUNCT
gs-4321	899	48	2019	2019	NUM
gs-4321	899	49	)	)	PUNCT
gs-4321	899	50	.	.	PUNCT
gs-4321	900	1	slide	slide	NOUN
gs-4321	900	2	-	-	PUNCT
gs-4321	900	3	seq	seq	NOUN
gs-4321	900	4	:	:	PUNCT
gs-4321	900	5	a	a	DET
gs-4321	900	6	scalable	scalable	ADJ
gs-4321	900	7	technology	technology	NOUN
gs-4321	900	8	for	for	ADP
gs-4321	900	9	measuring	measure	VERB
gs-4321	900	10	genome	genome	NOUN
gs-4321	900	11	-	-	PUNCT
gs-4321	900	12	wide	wide	ADJ
gs-4321	900	13	expression	expression	NOUN
gs-4321	900	14	at	at	ADP
gs-4321	900	15	high	high	ADJ
gs-4321	900	16	spatial	spatial	ADJ
gs-4321	900	17	resolution	resolution	NOUN
gs-4321	900	18	.	.	PUNCT
gs-4321	901	1	science	science	NOUN
gs-4321	901	2	,	,	PUNCT
gs-4321	901	3	363(6434	363(6434	NUM
gs-4321	901	4	)	)	PUNCT
gs-4321	901	5	,	,	PUNCT
gs-4321	901	6	1463–1467	1463–1467	NUM
gs-4321	901	7	.	.	PUNCT
gs-4321	902	1	roth	roth	PROPN
gs-4321	902	2	,	,	PUNCT
gs-4321	902	3	a.	a.	PROPN
gs-4321	902	4	,	,	PUNCT
gs-4321	902	5	khattra	khattra	PROPN
gs-4321	902	6	,	,	PUNCT
gs-4321	902	7	j.	j.	PROPN
gs-4321	902	8	,	,	PUNCT
gs-4321	902	9	yap	yap	PROPN
gs-4321	902	10	,	,	PUNCT
gs-4321	902	11	d.	d.	PROPN
gs-4321	902	12	,	,	PUNCT
gs-4321	902	13	wan	wan	PROPN
gs-4321	902	14	,	,	PUNCT
gs-4321	902	15	a.	a.	PROPN
gs-4321	902	16	,	,	PUNCT
gs-4321	902	17	laks	laks	PROPN
gs-4321	902	18	,	,	PUNCT
gs-4321	902	19	e.(2014	e.(2014	PROPN
gs-4321	902	20	)	)	PUNCT
gs-4321	902	21	.	.	PUNCT
gs-4321	903	1	pyclone	pyclone	NOUN
gs-4321	903	2	:	:	PUNCT
gs-4321	903	3	statistical	statistical	ADJ
gs-4321	903	4	inference	inference	NOUN
gs-4321	903	5	of	of	ADP
gs-4321	903	6	clonal	clonal	ADJ
gs-4321	903	7	population	population	NOUN
gs-4321	903	8	structure	structure	NOUN
gs-4321	903	9	in	in	ADP
gs-4321	903	10	cancer	cancer	NOUN
gs-4321	903	11	.	.	PUNCT
gs-4321	904	1	nature	nature	NOUN
gs-4321	904	2	methods	method	NOUN
gs-4321	904	3	,	,	PUNCT
gs-4321	904	4	11(4	11(4	NUM
gs-4321	904	5	)	)	PUNCT
gs-4321	904	6	,	,	PUNCT
gs-4321	904	7	396–398	396–398	NUM
gs-4321	904	8	.	.	PUNCT
gs-4321	905	1	saelens	saelens	PROPN
gs-4321	905	2	,	,	PUNCT
gs-4321	905	3	w.	w.	PROPN
gs-4321	905	4	,	,	PUNCT
gs-4321	905	5	cannoodt	cannoodt	PROPN
gs-4321	905	6	,	,	PUNCT
gs-4321	905	7	r.	r.	PROPN
gs-4321	905	8	,	,	PUNCT
gs-4321	905	9	todorov	todorov	PROPN
gs-4321	905	10	,	,	PUNCT
gs-4321	905	11	h.	h.	PROPN
gs-4321	905	12	,	,	PUNCT
gs-4321	905	13	&	&	CCONJ
gs-4321	905	14	saeys	saey	NOUN
gs-4321	905	15	,	,	PUNCT
gs-4321	905	16	y.	y.	PROPN
gs-4321	905	17	(	(	PUNCT
gs-4321	905	18	2019	2019	NUM
gs-4321	905	19	)	)	PUNCT
gs-4321	905	20	.	.	PUNCT
gs-4321	906	1	a	a	DET
gs-4321	906	2	comparison	comparison	NOUN
gs-4321	906	3	of	of	ADP
gs-4321	906	4	singlecell	singlecell	NOUN
gs-4321	906	5	trajectory	trajectory	NOUN
gs-4321	906	6	inference	inference	NOUN
gs-4321	906	7	methods	method	NOUN
gs-4321	906	8	.	.	PUNCT
gs-4321	907	1	nature	nature	NOUN
gs-4321	907	2	biotechnology	biotechnology	NOUN
gs-4321	907	3	,	,	PUNCT
gs-4321	907	4	37(5	37(5	NUM
gs-4321	907	5	)	)	PUNCT
gs-4321	907	6	,	,	PUNCT
gs-4321	908	1	547–554	547–554	NUM
gs-4321	908	2	.	.	PUNCT
gs-4321	909	1	sharma	sharma	PROPN
gs-4321	909	2	,	,	PUNCT
gs-4321	909	3	s.	s.	PROPN
gs-4321	909	4	v.	v.	PROPN
gs-4321	909	5	,	,	PUNCT
gs-4321	909	6	lee	lee	PROPN
gs-4321	909	7	,	,	PUNCT
gs-4321	909	8	d.	d.	PROPN
gs-4321	909	9	y.	y.	PROPN
gs-4321	909	10	,	,	PUNCT
gs-4321	909	11	li	li	PROPN
gs-4321	909	12	,	,	PUNCT
gs-4321	909	13	b.	b.	PROPN
gs-4321	909	14	,	,	PUNCT
gs-4321	909	15	quinlan	quinlan	PROPN
gs-4321	909	16	,	,	PUNCT
gs-4321	909	17	m.	m.	NOUN
gs-4321	909	18	p.	p.	PROPN
gs-4321	909	19	(	(	PUNCT
gs-4321	909	20	2010	2010	NUM
gs-4321	909	21	)	)	PUNCT
gs-4321	909	22	.	.	PUNCT
gs-4321	910	1	a	a	DET
gs-4321	910	2	chromatin	chromatin	NOUN
gs-4321	910	3	-	-	PUNCT
gs-4321	910	4	mediated	mediate	VERB
gs-4321	910	5	reversible	reversible	ADJ
gs-4321	910	6	drug	drug	NOUN
gs-4321	910	7	-	-	PUNCT
gs-4321	910	8	tolerant	tolerant	ADJ
gs-4321	910	9	state	state	NOUN
gs-4321	910	10	in	in	ADP
gs-4321	910	11	cancer	cancer	NOUN
gs-4321	910	12	cell	cell	NOUN
gs-4321	910	13	subpopulations	subpopulation	NOUN
gs-4321	910	14	.	.	PUNCT
gs-4321	911	1	cell	cell	NOUN
gs-4321	911	2	,	,	PUNCT
gs-4321	911	3	141(1	141(1	NUM
gs-4321	911	4	)	)	PUNCT
gs-4321	911	5	,	,	PUNCT
gs-4321	911	6	69–80	69–80	NUM
gs-4321	911	7	.	.	PUNCT
gs-4321	912	1	shibue	shibue	NOUN
gs-4321	912	2	,	,	PUNCT
gs-4321	912	3	t.	t.	PROPN
gs-4321	912	4	,	,	PUNCT
gs-4321	912	5	&	&	CCONJ
gs-4321	912	6	weinberg	weinberg	PROPN
gs-4321	912	7	,	,	PUNCT
gs-4321	912	8	r.	r.	PROPN
gs-4321	912	9	a.	a.	PROPN
gs-4321	912	10	(	(	PUNCT
gs-4321	912	11	2017	2017	NUM
gs-4321	912	12	)	)	PUNCT
gs-4321	912	13	.	.	PUNCT
gs-4321	913	1	emt	emt	PROPN
gs-4321	913	2	,	,	PUNCT
gs-4321	913	3	cscs	cscs	PROPN
gs-4321	913	4	,	,	PUNCT
gs-4321	913	5	and	and	CCONJ
gs-4321	913	6	drug	drug	NOUN
gs-4321	913	7	resistance	resistance	NOUN
gs-4321	913	8	:	:	PUNCT
gs-4321	913	9	the	the	DET
gs-4321	913	10	mechanistic	mechanistic	PROPN
gs-4321	913	11	link	link	NOUN
gs-4321	913	12	and	and	CCONJ
gs-4321	913	13	clinical	clinical	ADJ
gs-4321	913	14	implications	implication	NOUN
gs-4321	913	15	.	.	PUNCT
gs-4321	914	1	nature	nature	NOUN
gs-4321	914	2	reviews	review	VERB
gs-4321	914	3	clinical	clinical	ADJ
gs-4321	914	4	oncology	oncology	NOUN
gs-4321	914	5	,	,	PUNCT
gs-4321	914	6	14(10	14(10	NUM
gs-4321	914	7	)	)	PUNCT
gs-4321	914	8	,	,	PUNCT
gs-4321	914	9	611–629	611–629	NUM
gs-4321	914	10	.	.	PUNCT
gs-4321	914	11	stoeckius	stoeckius	PROPN
gs-4321	914	12	,	,	PUNCT
gs-4321	914	13	m.	m.	NOUN
gs-4321	914	14	,	,	PUNCT
gs-4321	914	15	hafemeister	hafemeister	PROPN
gs-4321	914	16	,	,	PUNCT
gs-4321	914	17	c.	c.	PROPN
gs-4321	914	18	,	,	PUNCT
gs-4321	914	19	stephenson	stephenson	PROPN
gs-4321	914	20	,	,	PUNCT
gs-4321	914	21	w.	w.	PROPN
gs-4321	914	22	,	,	PUNCT
gs-4321	914	23	houck	houck	PROPN
gs-4321	914	24	-	-	PUNCT
gs-4321	914	25	loomis	loomis	PROPN
gs-4321	914	26	,	,	PUNCT
gs-4321	914	27	b.	b.	PROPN
gs-4321	914	28	,	,	PUNCT
gs-4321	914	29	chattopadhyay	chattopadhyay	PROPN
gs-4321	914	30	,	,	PUNCT
gs-4321	914	31	p.	p.	PROPN
gs-4321	914	32	k.	k.	PROPN
gs-4321	914	33	,	,	PUNCT
gs-4321	914	34	swerdlow	swerdlow	PROPN
gs-4321	914	35	,	,	PUNCT
gs-4321	914	36	h.	h.	PROPN
gs-4321	914	37	,	,	PUNCT
gs-4321	914	38	satija	satija	PROPN
gs-4321	914	39	,	,	PUNCT
gs-4321	914	40	r.	r.	PROPN
gs-4321	914	41	,	,	PUNCT
gs-4321	914	42	&	&	CCONJ
gs-4321	914	43	smibert	smibert	PROPN
gs-4321	914	44	,	,	PUNCT
gs-4321	914	45	p.	p.	NOUN
gs-4321	914	46	(	(	PUNCT
gs-4321	914	47	2017	2017	NUM
gs-4321	914	48	)	)	PUNCT
gs-4321	914	49	.	.	PUNCT
gs-4321	915	1	simultaneous	simultaneous	ADJ
gs-4321	915	2	epitope	epitope	NOUN
gs-4321	915	3	and	and	CCONJ
gs-4321	915	4	transcriptome	transcriptome	ADJ
gs-4321	915	5	measurement	measurement	NOUN
gs-4321	915	6	in	in	ADP
gs-4321	915	7	single	single	ADJ
gs-4321	915	8	cells	cell	NOUN
gs-4321	915	9	.	.	PUNCT
gs-4321	916	1	nature	nature	NOUN
gs-4321	916	2	methods	method	NOUN
gs-4321	916	3	,	,	PUNCT
gs-4321	916	4	14(9	14(9	NUM
gs-4321	916	5	)	)	PUNCT
gs-4321	916	6	,	,	PUNCT
gs-4321	916	7	865–868	865–868	NUM
gs-4321	916	8	.	.	PUNCT
gs-4321	917	1	street	street	PROPN
gs-4321	917	2	,	,	PUNCT
gs-4321	917	3	k.	k.	PROPN
gs-4321	917	4	,	,	PUNCT
gs-4321	917	5	risso	risso	PROPN
gs-4321	917	6	,	,	PUNCT
gs-4321	917	7	d.	d.	PROPN
gs-4321	917	8	,	,	PUNCT
gs-4321	917	9	fletcher	fletcher	PROPN
gs-4321	917	10	,	,	PUNCT
gs-4321	917	11	r.	r.	PROPN
gs-4321	917	12	b.	b.	PROPN
gs-4321	917	13	,	,	PUNCT
gs-4321	917	14	das	das	PROPN
gs-4321	917	15	,	,	PUNCT
gs-4321	917	16	(	(	PUNCT
gs-4321	917	17	2018	2018	NUM
gs-4321	917	18	)	)	PUNCT
gs-4321	917	19	.	.	PUNCT
gs-4321	918	1	slingshot	slingshot	PROPN
gs-4321	918	2	:	:	PUNCT
gs-4321	918	3	cell	cell	NOUN
gs-4321	918	4	lineage	lineage	NOUN
gs-4321	918	5	and	and	CCONJ
gs-4321	918	6	pseudotime	pseudotime	NOUN
gs-4321	918	7	inference	inference	NOUN
gs-4321	918	8	for	for	ADP
gs-4321	918	9	single	single	ADJ
gs-4321	918	10	-	-	PUNCT
gs-4321	918	11	cell	cell	NOUN
gs-4321	918	12	transcriptomics	transcriptomic	NOUN
gs-4321	918	13	.	.	PUNCT
gs-4321	919	1	bmc	bmc	ADJ
gs-4321	919	2	genomics	genomics	PROPN
gs-4321	919	3	,	,	PUNCT
gs-4321	919	4	19(1	19(1	NUM
gs-4321	919	5	)	)	PUNCT
gs-4321	919	6	,	,	PUNCT
gs-4321	919	7	477	477	X
gs-4321	919	8	.	.	PUNCT
gs-4321	920	1	georgian	georgian	NOUN
gs-4321	920	2	scientists/	scientists/	NUM
gs-4321	920	3	.	.	PUNCT
gs-4321	921	1	7	7	NUM
gs-4321	921	2	n	n	DET
gs-4321	921	3	4	4	NUM
gs-4321	921	4	,	,	PUNCT
gs-4321	921	5	2025	2025	NUM
gs-4321	921	6	383	383	NUM
gs-4321	921	7	stuart	stuart	PROPN
gs-4321	921	8	,	,	PUNCT
gs-4321	921	9	t.	t.	PROPN
gs-4321	921	10	,	,	PUNCT
gs-4321	921	11	butler	butler	PROPN
gs-4321	921	12	,	,	PUNCT
gs-4321	921	13	a.	a.	PROPN
gs-4321	921	14	,	,	PUNCT
gs-4321	921	15	hoffman	hoffman	NOUN
gs-4321	921	16	,	,	PUNCT
gs-4321	921	17	p.	p.	PROPN
gs-4321	921	18	,	,	PUNCT
gs-4321	921	19	hafemeister	hafemeister	PROPN
gs-4321	921	20	,	,	PUNCT
gs-4321	921	21	c.	c.	PROPN
gs-4321	921	22	,	,	PUNCT
gs-4321	921	23	papalexi	papalexi	PROPN
gs-4321	921	24	,	,	PUNCT
gs-4321	921	25	e.	e.	PROPN
gs-4321	921	26	,	,	PUNCT
gs-4321	921	27	mauck	mauck	NOUN
gs-4321	921	28	iii	iii	PROPN
gs-4321	921	29	,	,	PUNCT
gs-4321	921	30	w.	w.	PROPN
gs-4321	921	31	m.	m.	PROPN
gs-4321	921	32	,	,	PUNCT
gs-4321	921	33	hao	hao	PROPN
gs-4321	921	34	,	,	PUNCT
gs-4321	921	35	y.	y.	PROPN
gs-4321	921	36	,	,	PUNCT
gs-4321	921	37	stoeckius	stoeckius	PROPN
gs-4321	921	38	,	,	PUNCT
gs-4321	921	39	m.	m.	NOUN
gs-4321	921	40	,	,	PUNCT
gs-4321	921	41	smibert	smibert	PROPN
gs-4321	921	42	,	,	PUNCT
gs-4321	921	43	p.	p.	NOUN
gs-4321	921	44	,	,	PUNCT
gs-4321	921	45	&	&	CCONJ
gs-4321	921	46	satija	satija	PROPN
gs-4321	921	47	,	,	PUNCT
gs-4321	921	48	r.	r.	PROPN
gs-4321	921	49	(	(	PUNCT
gs-4321	921	50	2019	2019	NUM
gs-4321	921	51	)	)	PUNCT
gs-4321	921	52	.	.	PUNCT
gs-4321	922	1	comprehensive	comprehensive	ADJ
gs-4321	922	2	integration	integration	NOUN
gs-4321	922	3	of	of	ADP
gs-4321	922	4	single	single	ADJ
gs-4321	922	5	-	-	PUNCT
gs-4321	922	6	cell	cell	NOUN
gs-4321	922	7	data	datum	NOUN
gs-4321	922	8	.	.	PUNCT
gs-4321	923	1	cell	cell	NOUN
gs-4321	923	2	,	,	PUNCT
gs-4321	923	3	177(7	177(7	NUM
gs-4321	923	4	)	)	PUNCT
gs-4321	923	5	,	,	PUNCT
gs-4321	923	6	1888–1902.e21	1888–1902.e21	NUM
gs-4321	923	7	.	.	PUNCT
gs-4321	924	1	su	su	PROPN
gs-4321	924	2	,	,	PUNCT
gs-4321	924	3	y.	y.	PROPN
gs-4321	924	4	,	,	PUNCT
gs-4321	924	5	wei	wei	PROPN
gs-4321	924	6	,	,	PUNCT
gs-4321	924	7	w.	w.	PROPN
gs-4321	924	8	,	,	PUNCT
gs-4321	924	9	robert	robert	PROPN
gs-4321	924	10	,	,	PUNCT
gs-4321	924	11	l.	l.	PROPN
gs-4321	924	12	,	,	PUNCT
gs-4321	924	13	xue	xue	PROPN
gs-4321	924	14	,	,	PUNCT
gs-4321	924	15	m.	m.	NOUN
gs-4321	924	16	(	(	PUNCT
gs-4321	924	17	2017	2017	NUM
gs-4321	924	18	)	)	PUNCT
gs-4321	924	19	.	.	PUNCT
gs-4321	925	1	single	single	ADJ
gs-4321	925	2	-	-	PUNCT
gs-4321	925	3	cell	cell	NOUN
gs-4321	925	4	analysis	analysis	NOUN
gs-4321	925	5	resolves	resolve	VERB
gs-4321	925	6	the	the	DET
gs-4321	925	7	cell	cell	NOUN
gs-4321	925	8	state	state	NOUN
gs-4321	925	9	transition	transition	NOUN
gs-4321	925	10	and	and	CCONJ
gs-4321	925	11	signaling	signal	VERB
gs-4321	925	12	dynamics	dynamic	NOUN
gs-4321	925	13	associated	associate	VERB
gs-4321	925	14	with	with	ADP
gs-4321	925	15	melanoma	melanoma	NOUN
gs-4321	925	16	drug	drug	NOUN
gs-4321	925	17	-	-	PUNCT
gs-4321	925	18	induced	induce	VERB
gs-4321	925	19	resistance	resistance	NOUN
gs-4321	925	20	.	.	PUNCT
gs-4321	926	1	proceedings	proceeding	NOUN
gs-4321	926	2	of	of	ADP
gs-4321	926	3	the	the	DET
gs-4321	926	4	national	national	PROPN
gs-4321	926	5	academy	academy	PROPN
gs-4321	926	6	of	of	ADP
gs-4321	926	7	sciences	sciences	PROPN
gs-4321	926	8	,	,	PUNCT
gs-4321	926	9	114(52	114(52	NUM
gs-4321	926	10	)	)	PUNCT
gs-4321	926	11	,	,	PUNCT
gs-4321	926	12	13679–13684	13679–13684	NUM
gs-4321	926	13	.	.	PUNCT
gs-4321	926	14	teschendorff	teschendorff	PROPN
gs-4321	926	15	,	,	PUNCT
gs-4321	926	16	a.	a.	PROPN
gs-4321	926	17	e.	e.	PROPN
gs-4321	926	18	,	,	PUNCT
gs-4321	926	19	&	&	CCONJ
gs-4321	926	20	enver	enver	PROPN
gs-4321	926	21	,	,	PUNCT
gs-4321	926	22	t.	t.	PROPN
gs-4321	926	23	(	(	PUNCT
gs-4321	926	24	2017	2017	NUM
gs-4321	926	25	)	)	PUNCT
gs-4321	926	26	.	.	PUNCT
gs-4321	927	1	single	single	ADJ
gs-4321	927	2	-	-	PUNCT
gs-4321	927	3	cell	cell	NOUN
gs-4321	927	4	entropy	entropy	NOUN
gs-4321	927	5	for	for	ADP
gs-4321	927	6	accurate	accurate	ADJ
gs-4321	927	7	estimation	estimation	NOUN
gs-4321	927	8	of	of	ADP
gs-4321	927	9	differentiation	differentiation	NOUN
gs-4321	927	10	potency	potency	NOUN
gs-4321	927	11	from	from	ADP
gs-4321	927	12	a	a	DET
gs-4321	927	13	cell	cell	NOUN
gs-4321	927	14	's	's	PART
gs-4321	927	15	transcriptome	transcriptome	NOUN
gs-4321	927	16	.	.	PUNCT
gs-4321	928	1	nature	nature	NOUN
gs-4321	928	2	communications	communication	NOUN
gs-4321	928	3	,	,	PUNCT
gs-4321	928	4	8(1	8(1	NOUN
gs-4321	928	5	)	)	PUNCT
gs-4321	928	6	,	,	PUNCT
gs-4321	928	7	15599	15599	NUM
gs-4321	928	8	.	.	PUNCT
gs-4321	929	1	tirosh	tirosh	NOUN
gs-4321	929	2	,	,	PUNCT
gs-4321	929	3	i.	i.	PROPN
gs-4321	929	4	,	,	PUNCT
gs-4321	929	5	izar	izar	PROPN
gs-4321	929	6	,	,	PUNCT
gs-4321	929	7	b.	b.	PROPN
gs-4321	929	8	,	,	PUNCT
gs-4321	929	9	prakadan	prakadan	PROPN
gs-4321	929	10	,	,	PUNCT
gs-4321	929	11	s.	s.	PROPN
gs-4321	929	12	m.	m.	PROPN
gs-4321	929	13	,	,	PUNCT
gs-4321	929	14	wadsworth	wadsworth	PROPN
gs-4321	929	15	ii	ii	PROPN
gs-4321	929	16	,	,	PUNCT
gs-4321	929	17	m.	m.	NOUN
gs-4321	929	18	h.(2016	h.(2016	PROPN
gs-4321	929	19	)	)	PUNCT
gs-4321	929	20	.	.	PUNCT
gs-4321	930	1	dissecting	dissect	VERB
gs-4321	930	2	the	the	DET
gs-4321	930	3	multicellular	multicellular	ADJ
gs-4321	930	4	ecosystem	ecosystem	NOUN
gs-4321	930	5	of	of	ADP
gs-4321	930	6	metastatic	metastatic	ADJ
gs-4321	930	7	melanoma	melanoma	NOUN
gs-4321	930	8	by	by	ADP
gs-4321	930	9	single	single	ADJ
gs-4321	930	10	-	-	PUNCT
gs-4321	930	11	cell	cell	NOUN
gs-4321	930	12	rna	rna	NOUN
gs-4321	930	13	-	-	PUNCT
gs-4321	930	14	seq	seq	NOUN
gs-4321	930	15	.	.	PUNCT
gs-4321	931	1	science	science	NOUN
gs-4321	931	2	,	,	PUNCT
gs-4321	931	3	352(6282	352(6282	NUM
gs-4321	931	4	)	)	PUNCT
gs-4321	931	5	,	,	PUNCT
gs-4321	931	6	189–196	189–196	NUM
gs-4321	931	7	.	.	PUNCT
gs-4321	932	1	trapnell	trapnell	INTJ
gs-4321	932	2	,	,	PUNCT
gs-4321	932	3	c.	c.	PROPN
gs-4321	932	4	,	,	PUNCT
gs-4321	932	5	cacchiarelli	cacchiarelli	PROPN
gs-4321	932	6	,	,	PUNCT
gs-4321	932	7	d.	d.	PROPN
gs-4321	932	8	,	,	PUNCT
gs-4321	932	9	grimsby	grimsby	PROPN
gs-4321	932	10	,	,	PUNCT
gs-4321	932	11	j.(2014	j.(2014	PROPN
gs-4321	932	12	)	)	PUNCT
gs-4321	932	13	.	.	PUNCT
gs-4321	933	1	the	the	DET
gs-4321	933	2	dynamics	dynamic	NOUN
gs-4321	933	3	and	and	CCONJ
gs-4321	933	4	regulators	regulator	NOUN
gs-4321	933	5	of	of	ADP
gs-4321	933	6	cell	cell	NOUN
gs-4321	933	7	fate	fate	NOUN
gs-4321	933	8	decisions	decision	NOUN
gs-4321	933	9	are	be	AUX
gs-4321	933	10	revealed	reveal	VERB
gs-4321	933	11	by	by	ADP
gs-4321	933	12	pseudotemporal	pseudotemporal	ADJ
gs-4321	933	13	ordering	ordering	NOUN
gs-4321	933	14	of	of	ADP
gs-4321	933	15	single	single	ADJ
gs-4321	933	16	cells	cell	NOUN
gs-4321	933	17	.	.	PUNCT
gs-4321	934	1	nature	nature	NOUN
gs-4321	934	2	biotechnology	biotechnology	NOUN
gs-4321	934	3	,	,	PUNCT
gs-4321	934	4	32(4	32(4	NUM
gs-4321	934	5	)	)	PUNCT
gs-4321	934	6	,	,	PUNCT
gs-4321	934	7	381–386	381–386	NUM
gs-4321	934	8	.	.	PUNCT
gs-4321	935	1	tsoi	tsoi	PROPN
gs-4321	935	2	,	,	PUNCT
gs-4321	935	3	j.	j.	PROPN
gs-4321	935	4	,	,	PUNCT
gs-4321	935	5	robert	robert	PROPN
gs-4321	935	6	,	,	PUNCT
gs-4321	935	7	l.	l.	PROPN
gs-4321	935	8	,	,	PUNCT
gs-4321	935	9	paraiso	paraiso	PROPN
gs-4321	935	10	,	,	PUNCT
gs-4321	935	11	k.	k.	PROPN
gs-4321	935	12	,	,	PUNCT
gs-4321	935	13	galvan	galvan	PROPN
gs-4321	935	14	,	,	PUNCT
gs-4321	935	15	c.(2018	c.(2018	PROPN
gs-4321	935	16	)	)	PUNCT
gs-4321	935	17	.	.	PUNCT
gs-4321	936	1	multi	multi	ADJ
gs-4321	936	2	-	-	ADJ
gs-4321	936	3	stage	stage	ADJ
gs-4321	936	4	differentiation	differentiation	NOUN
gs-4321	936	5	defines	define	VERB
gs-4321	936	6	melanoma	melanoma	NOUN
gs-4321	936	7	subtypes	subtype	NOUN
gs-4321	936	8	with	with	ADP
gs-4321	936	9	differential	differential	ADJ
gs-4321	936	10	vulnerability	vulnerability	NOUN
gs-4321	936	11	to	to	ADP
gs-4321	936	12	drug	drug	NOUN
gs-4321	936	13	-	-	PUNCT
gs-4321	936	14	induced	induce	VERB
gs-4321	936	15	iron	iron	NOUN
gs-4321	936	16	-	-	PUNCT
gs-4321	936	17	dependent	dependent	ADJ
gs-4321	936	18	oxidative	oxidative	ADJ
gs-4321	936	19	stress	stress	NOUN
gs-4321	936	20	.	.	PUNCT
gs-4321	937	1	cancer	cancer	NOUN
gs-4321	937	2	cell	cell	NOUN
gs-4321	937	3	,	,	PUNCT
gs-4321	937	4	33(5	33(5	NUM
gs-4321	937	5	)	)	PUNCT
gs-4321	937	6	,	,	PUNCT
gs-4321	937	7	890–904.e5	890–904.e5	NUM
gs-4321	937	8	.	.	PUNCT
gs-4321	938	1	vaughan	vaughan	PROPN
gs-4321	938	2	,	,	PUNCT
gs-4321	938	3	a.	a.	PROPN
gs-4321	938	4	e.	e.	PROPN
gs-4321	938	5	,	,	PUNCT
gs-4321	938	6	&	&	CCONJ
gs-4321	938	7	chapman	chapman	PROPN
gs-4321	938	8	,	,	PUNCT
gs-4321	938	9	h.	h.	PROPN
gs-4321	938	10	a.	a.	PROPN
gs-4321	938	11	(	(	PUNCT
gs-4321	938	12	2013	2013	NUM
gs-4321	938	13	)	)	PUNCT
gs-4321	938	14	.	.	PUNCT
gs-4321	939	1	regenerative	regenerative	ADJ
gs-4321	939	2	activity	activity	NOUN
gs-4321	939	3	of	of	ADP
gs-4321	939	4	the	the	DET
gs-4321	939	5	lung	lung	NOUN
gs-4321	939	6	after	after	ADP
gs-4321	939	7	epithelial	epithelial	ADJ
gs-4321	939	8	injury	injury	NOUN
gs-4321	939	9	.	.	PUNCT
gs-4321	940	1	biochimica	biochimica	PROPN
gs-4321	940	2	et	et	PROPN
gs-4321	940	3	biophysica	biophysica	PROPN
gs-4321	940	4	acta	acta	PROPN
gs-4321	940	5	(	(	PUNCT
gs-4321	940	6	bba)-molecular	bba)-molecular	ADJ
gs-4321	940	7	basis	basis	NOUN
gs-4321	940	8	of	of	ADP
gs-4321	940	9	disease	disease	NOUN
gs-4321	940	10	,	,	PUNCT
gs-4321	940	11	1832(7	1832(7	NOUN
gs-4321	940	12	)	)	PUNCT
gs-4321	940	13	,	,	PUNCT
gs-4321	940	14	922–930	922–930	NUM
gs-4321	940	15	.	.	PUNCT
gs-4321	941	1	wolf	wolf	PROPN
gs-4321	941	2	,	,	PUNCT
gs-4321	941	3	f.	f.	PROPN
gs-4321	941	4	a.	a.	PROPN
gs-4321	941	5	,	,	PUNCT
gs-4321	941	6	angerer	angerer	PROPN
gs-4321	941	7	,	,	PUNCT
gs-4321	941	8	p.	p.	PROPN
gs-4321	941	9	,	,	PUNCT
gs-4321	941	10	&	&	CCONJ
gs-4321	941	11	theis	theis	PROPN
gs-4321	941	12	,	,	PUNCT
gs-4321	941	13	f.	f.	PROPN
gs-4321	941	14	j.	j.	PROPN
gs-4321	941	15	(	(	PUNCT
gs-4321	941	16	2018	2018	NUM
gs-4321	941	17	)	)	PUNCT
gs-4321	941	18	.	.	PUNCT
gs-4321	942	1	scanpy	scanpy	NOUN
gs-4321	942	2	:	:	PUNCT
gs-4321	942	3	large	large	ADJ
gs-4321	942	4	-	-	PUNCT
gs-4321	942	5	scale	scale	NOUN
gs-4321	942	6	single	single	ADJ
gs-4321	942	7	-	-	PUNCT
gs-4321	942	8	cell	cell	NOUN
gs-4321	942	9	gene	gene	NOUN
gs-4321	942	10	expression	expression	NOUN
gs-4321	942	11	data	datum	NOUN
gs-4321	942	12	analysis	analysis	NOUN
gs-4321	942	13	.	.	PUNCT
gs-4321	943	1	genome	genome	NOUN
gs-4321	943	2	biology	biology	NOUN
gs-4321	943	3	,	,	PUNCT
gs-4321	943	4	19(1	19(1	NUM
gs-4321	943	5	)	)	PUNCT
gs-4321	943	6	,	,	PUNCT
gs-4321	943	7	15	15	NUM
gs-4321	943	8	.	.	PUNCT
gs-4321	944	1	wolf	wolf	PROPN
gs-4321	944	2	,	,	PUNCT
gs-4321	944	3	f.	f.	PROPN
gs-4321	944	4	a.	a.	PROPN
gs-4321	944	5	,	,	PUNCT
gs-4321	944	6	hamey	hamey	VERB
gs-4321	944	7	,	,	PUNCT
gs-4321	944	8	f.	f.	PROPN
gs-4321	944	9	k.	k.	PROPN
gs-4321	944	10	,	,	PUNCT
gs-4321	944	11	plass	plass	PROPN
gs-4321	944	12	,	,	PUNCT
gs-4321	944	13	m.	m.	NOUN
gs-4321	944	14	,	,	PUNCT
gs-4321	944	15	solana	solana	PROPN
gs-4321	944	16	,	,	PUNCT
gs-4321	944	17	j.	j.	PROPN
gs-4321	944	18	,	,	PUNCT
gs-4321	944	19	dahlin	dahlin	PROPN
gs-4321	944	20	,	,	PUNCT
gs-4321	944	21	j.	j.	PROPN
gs-4321	944	22	s.	s.	PROPN
gs-4321	944	23	(	(	PUNCT
gs-4321	944	24	2019	2019	NUM
gs-4321	944	25	)	)	PUNCT
gs-4321	944	26	.	.	PUNCT
gs-4321	945	1	paga	paga	NOUN
gs-4321	945	2	:	:	PUNCT
gs-4321	945	3	graph	graph	NOUN
gs-4321	945	4	abstraction	abstraction	NOUN
gs-4321	945	5	reconciles	reconcile	VERB
gs-4321	945	6	clustering	cluster	VERB
gs-4321	945	7	with	with	ADP
gs-4321	945	8	trajectory	trajectory	NOUN
gs-4321	945	9	inference	inference	NOUN
gs-4321	945	10	through	through	ADP
gs-4321	945	11	a	a	DET
gs-4321	945	12	topology	topology	NOUN
gs-4321	945	13	preserving	preserve	VERB
gs-4321	945	14	map	map	NOUN
gs-4321	945	15	of	of	ADP
gs-4321	945	16	single	single	ADJ
gs-4321	945	17	cells	cell	NOUN
gs-4321	945	18	.	.	PUNCT
gs-4321	946	1	genome	genome	NOUN
gs-4321	946	2	biology	biology	NOUN
gs-4321	946	3	,	,	PUNCT
gs-4321	946	4	20(1	20(1	NUM
gs-4321	946	5	)	)	PUNCT
gs-4321	946	6	,	,	PUNCT
gs-4321	946	7	59	59	NUM
gs-4321	946	8	.	.	PUNCT
gs-4321	946	9	wu	wu	PROPN
gs-4321	946	10	,	,	PUNCT
gs-4321	946	11	s.	s.	PROPN
gs-4321	946	12	z.	z.	PROPN
gs-4321	946	13	,	,	PUNCT
gs-4321	946	14	al	al	PROPN
gs-4321	946	15	-	-	PUNCT
gs-4321	946	16	eryani	eryani	PROPN
gs-4321	946	17	,	,	PUNCT
gs-4321	946	18	g.	g.	PROPN
gs-4321	946	19	,	,	PUNCT
gs-4321	946	20	roden	roden	PROPN
gs-4321	946	21	,	,	PUNCT
gs-4321	946	22	d.	d.	PROPN
gs-4321	946	23	l.	l.	PROPN
gs-4321	946	24	,	,	PUNCT
gs-4321	946	25	junankar	junankar	PROPN
gs-4321	946	26	,	,	PUNCT
gs-4321	946	27	s.	s.	PROPN
gs-4321	946	28	,	,	PUNCT
gs-4321	946	29	harvey	harvey	PROPN
gs-4321	946	30	.	.	PUNCT
gs-4321	947	1	(	(	PUNCT
gs-4321	947	2	2021	2021	NUM
gs-4321	947	3	)	)	PUNCT
gs-4321	947	4	.	.	PUNCT
gs-4321	948	1	a	a	DET
gs-4321	948	2	single	single	ADJ
gs-4321	948	3	-	-	PUNCT
gs-4321	948	4	cell	cell	NOUN
gs-4321	948	5	and	and	CCONJ
gs-4321	948	6	spatially	spatially	ADV
gs-4321	948	7	resolved	resolve	VERB
gs-4321	948	8	atlas	atlas	PROPN
gs-4321	948	9	of	of	ADP
gs-4321	948	10	human	human	ADJ
gs-4321	948	11	breast	breast	NOUN
gs-4321	948	12	cancers	cancer	NOUN
gs-4321	948	13	.	.	PUNCT
gs-4321	949	1	nature	nature	NOUN
gs-4321	949	2	genetics	genetic	NOUN
gs-4321	949	3	,	,	PUNCT
gs-4321	949	4	53(9	53(9	NOUN
gs-4321	949	5	)	)	PUNCT
gs-4321	949	6	,	,	PUNCT
gs-4321	949	7	1334	1334	NUM
gs-4321	949	8	–	–	PUNCT
gs-4321	949	9	1347	1347	NUM
gs-4321	949	10	.	.	PUNCT
gs-4321	950	1	zafar	zafar	PROPN
gs-4321	950	2	,	,	PUNCT
gs-4321	950	3	h.	h.	PROPN
gs-4321	950	4	,	,	PUNCT
gs-4321	950	5	wang	wang	PROPN
gs-4321	950	6	,	,	PUNCT
gs-4321	950	7	y.	y.	PROPN
gs-4321	950	8	,	,	PUNCT
gs-4321	950	9	nakhleh	nakhleh	PROPN
gs-4321	950	10	,	,	PUNCT
gs-4321	950	11	l.	l.	PROPN
gs-4321	950	12	,	,	PUNCT
gs-4321	950	13	navin	navin	PROPN
gs-4321	950	14	,	,	PUNCT
gs-4321	950	15	n.	n.	PROPN
gs-4321	950	16	,	,	PUNCT
gs-4321	950	17	&	&	CCONJ
gs-4321	950	18	chen	chen	PROPN
gs-4321	950	19	,	,	PUNCT
gs-4321	950	20	k.	k.	PROPN
gs-4321	950	21	(	(	PUNCT
gs-4321	950	22	2019	2019	NUM
gs-4321	950	23	)	)	PUNCT
gs-4321	950	24	.	.	PUNCT
gs-4321	951	1	monovar	monovar	NOUN
gs-4321	951	2	:	:	PUNCT
gs-4321	951	3	singlenucleotide	singlenucleotide	NOUN
gs-4321	951	4	variant	variant	NOUN
gs-4321	951	5	detection	detection	NOUN
gs-4321	951	6	in	in	ADP
gs-4321	951	7	single	single	ADJ
gs-4321	951	8	cells	cell	NOUN
gs-4321	951	9	.	.	PUNCT
gs-4321	952	1	nature	nature	NOUN
gs-4321	952	2	methods	method	NOUN
gs-4321	952	3	,	,	PUNCT
gs-4321	952	4	16(7	16(7	NUM
gs-4321	952	5	)	)	PUNCT
gs-4321	952	6	,	,	PUNCT
gs-4321	953	1	585–587	585–587	NUM
gs-4321	953	2	.	.	PUNCT
gs-4321	954	1	zhang	zhang	PROPN
gs-4321	954	2	,	,	PUNCT
gs-4321	954	3	m.	m.	NOUN
gs-4321	954	4	,	,	PUNCT
gs-4321	954	5	eichhorn	eichhorn	ADJ
gs-4321	954	6	,	,	PUNCT
gs-4321	954	7	s.	s.	PROPN
gs-4321	954	8	w.	w.	PROPN
gs-4321	954	9	,	,	PUNCT
gs-4321	954	10	zingg	zingg	PROPN
gs-4321	954	11	,	,	PUNCT
gs-4321	954	12	b.	b.	PROPN
gs-4321	954	13	,	,	PUNCT
gs-4321	954	14	yao	yao	PROPN
gs-4321	954	15	,	,	PUNCT
gs-4321	954	16	z.	z.	PROPN
gs-4321	954	17	,	,	PUNCT
gs-4321	954	18	cotter	cotter	PROPN
gs-4321	954	19	,	,	PUNCT
gs-4321	954	20	k.(2021	k.(2021	PROPN
gs-4321	954	21	)	)	PUNCT
gs-4321	954	22	.	.	PUNCT
gs-4321	955	1	spatially	spatially	ADV
gs-4321	955	2	resolved	resolve	VERB
gs-4321	955	3	cell	cell	NOUN
gs-4321	955	4	atlas	atlas	PROPN
gs-4321	955	5	of	of	ADP
gs-4321	955	6	the	the	DET
gs-4321	955	7	mouse	mouse	NOUN
gs-4321	955	8	primary	primary	ADJ
gs-4321	955	9	motor	motor	NOUN
gs-4321	955	10	cortex	cortex	NOUN
gs-4321	955	11	by	by	ADP
gs-4321	955	12	merfish	merfish	PROPN
gs-4321	955	13	.	.	PUNCT
gs-4321	956	1	nature	nature	PROPN
gs-4321	956	2	,	,	PUNCT
gs-4321	956	3	598(7879	598(7879	NUM
gs-4321	956	4	)	)	PUNCT
gs-4321	956	5	,	,	PUNCT
gs-4321	956	6	137	137	NUM
gs-4321	956	7	–	–	PUNCT
gs-4321	956	8	143	143	NUM
gs-4321	956	9	.	.	PUNCT
gs-4321	957	1	zheng	zheng	PROPN
gs-4321	957	2	,	,	PUNCT
gs-4321	957	3	g.	g.	PROPN
gs-4321	957	4	x.	x.	PROPN
gs-4321	957	5	y.	y.	PROPN
gs-4321	957	6	,	,	PUNCT
gs-4321	957	7	terry	terry	PROPN
gs-4321	957	8	,	,	PUNCT
gs-4321	957	9	j.	j.	PROPN
gs-4321	957	10	m.	m.	PROPN
gs-4321	957	11	(	(	PUNCT
gs-4321	957	12	2017	2017	NUM
gs-4321	957	13	)	)	PUNCT
gs-4321	957	14	.	.	PUNCT
gs-4321	958	1	massively	massively	ADV
gs-4321	958	2	parallel	parallel	VERB
gs-4321	958	3	digital	digital	ADJ
gs-4321	958	4	transcriptional	transcriptional	NOUN
gs-4321	958	5	profiling	profiling	NOUN
gs-4321	958	6	of	of	ADP
gs-4321	958	7	single	single	ADJ
gs-4321	958	8	cells	cell	NOUN
gs-4321	958	9	.	.	PUNCT
gs-4321	959	1	nature	nature	NOUN
gs-4321	959	2	communications	communication	NOUN
gs-4321	959	3	,	,	PUNCT
gs-4321	959	4	8(1	8(1	NOUN
gs-4321	959	5	)	)	PUNCT
gs-4321	959	6	,	,	PUNCT
gs-4321	959	7	14049	14049	NUM
gs-4321	959	8	.	.	PUNCT
gs-4321	960	1	sulashvili	sulashvili	NOUN
gs-4321	960	2	,	,	PUNCT
gs-4321	960	3	n.	n.	NOUN
gs-4321	960	4	,	,	PUNCT
gs-4321	960	5	gorgaslidze	gorgaslidze	PROPN
gs-4321	960	6	,	,	PUNCT
gs-4321	960	7	n.	n.	NOUN
gs-4321	960	8	,	,	PUNCT
gs-4321	960	9	gabunia	gabunia	NOUN
gs-4321	960	10	,	,	PUNCT
gs-4321	960	11	l.	l.	PROPN
gs-4321	960	12	,	,	PUNCT
gs-4321	960	13	giorgobiani	giorgobiani	PROPN
gs-4321	960	14	,	,	PUNCT
gs-4321	960	15	m.	m.	NOUN
gs-4321	960	16	,	,	PUNCT
gs-4321	960	17	&	&	CCONJ
gs-4321	960	18	ratiani	ratiani	PROPN
gs-4321	960	19	,	,	PUNCT
gs-4321	960	20	l.	l.	PROPN
gs-4321	960	21	(	(	PUNCT
gs-4321	960	22	2023	2023	NUM
gs-4321	960	23	)	)	PUNCT
gs-4321	960	24	.	.	PUNCT
gs-4321	961	1	manifestation	manifestation	NOUN
gs-4321	961	2	of	of	ADP
gs-4321	961	3	the	the	DET
gs-4321	961	4	particularities	particularity	NOUN
gs-4321	961	5	of	of	ADP
gs-4321	961	6	the	the	DET
gs-4321	961	7	usage	usage	NOUN
gs-4321	961	8	features	feature	NOUN
gs-4321	961	9	of	of	ADP
gs-4321	961	10	monoclonal	monoclonal	NOUN
gs-4321	961	11	antibodies	antibody	NOUN
gs-4321	961	12	in	in	ADP
gs-4321	961	13	various	various	ADJ
gs-4321	961	14	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-4321	961	15	applications	application	NOUN
gs-4321	961	16	.	.	PUNCT
gs-4321	962	1	experimental	experimental	ADJ
gs-4321	962	2	and	and	CCONJ
gs-4321	962	3	clinical	clinical	ADJ
gs-4321	962	4	medicine	medicine	NOUN
gs-4321	962	5	georgia	georgia	PROPN
gs-4321	962	6	,	,	PUNCT
gs-4321	962	7	(	(	PUNCT
gs-4321	962	8	4	4	NUM
gs-4321	962	9	)	)	PUNCT
gs-4321	962	10	,	,	PUNCT
gs-4321	962	11	52–57	52–57	NUM
gs-4321	962	12	.	.	PUNCT
gs-4321	963	1	georgian	georgian	NOUN
gs-4321	963	2	scientists/	scientists/	NUM
gs-4321	963	3	.	.	PUNCT
gs-4321	964	1	7	7	NUM
gs-4321	964	2	n	n	DET
gs-4321	964	3	4	4	NUM
gs-4321	964	4	,	,	PUNCT
gs-4321	964	5	2025	2025	NUM
gs-4321	964	6	384	384	NUM
gs-4321	964	7	sulashvili	sulashvili	NOUN
gs-4321	964	8	,	,	PUNCT
gs-4321	964	9	n.	n.	NOUN
gs-4321	964	10	,	,	PUNCT
gs-4321	964	11	gorgaslidze	gorgaslidze	PROPN
gs-4321	964	12	,	,	PUNCT
gs-4321	964	13	n.	n.	NOUN
gs-4321	964	14	,	,	PUNCT
gs-4321	964	15	gabunia	gabunia	NOUN
gs-4321	964	16	,	,	PUNCT
gs-4321	964	17	l.	l.	PROPN
gs-4321	964	18	,	,	PUNCT
gs-4321	964	19	beglaryan	beglaryan	ADJ
gs-4321	964	20	,	,	PUNCT
gs-4321	964	21	m.	m.	NOUN
gs-4321	964	22	(	(	PUNCT
gs-4321	964	23	2024	2024	NUM
gs-4321	964	24	)	)	PUNCT
gs-4321	964	25	.	.	PUNCT
gs-4321	965	1	the	the	DET
gs-4321	965	2	scientific	scientific	ADJ
gs-4321	965	3	discussion	discussion	NOUN
gs-4321	965	4	of	of	ADP
gs-4321	965	5	some	some	DET
gs-4321	965	6	issues	issue	NOUN
gs-4321	965	7	of	of	ADP
gs-4321	965	8	features	feature	NOUN
gs-4321	965	9	and	and	CCONJ
gs-4321	965	10	challenges	challenge	NOUN
gs-4321	965	11	of	of	ADP
gs-4321	965	12	using	use	VERB
gs-4321	965	13	of	of	ADP
gs-4321	965	14	car	car	NOUN
gs-4321	965	15	-	-	PUNCT
gs-4321	965	16	t	t	NOUN
gs-4321	965	17	cells	cell	NOUN
gs-4321	965	18	in	in	ADP
gs-4321	965	19	immunotherapy	immunotherapy	NOUN
gs-4321	965	20	.	.	PUNCT
gs-4321	966	1	georgian	georgian	ADJ
gs-4321	966	2	scientists	scientist	NOUN
gs-4321	966	3	,	,	PUNCT
gs-4321	966	4	6(4	6(4	NOUN
gs-4321	966	5	)	)	PUNCT
gs-4321	966	6	,	,	PUNCT
gs-4321	966	7	263–290	263–290	NUM
gs-4321	966	8	.	.	PUNCT
gs-4321	966	9	https://doi.org/10.52340/gs.2024.06.04.24	https://doi.org/10.52340/gs.2024.06.04.24	PROPN
gs-4321	966	10	sulashvili	sulashvili	NOUN
gs-4321	966	11	,	,	PUNCT
gs-4321	966	12	n.	n.	NOUN
gs-4321	966	13	,	,	PUNCT
gs-4321	966	14	gorgaslidze	gorgaslidze	PROPN
gs-4321	966	15	,	,	PUNCT
gs-4321	966	16	n.	n.	NOUN
gs-4321	966	17	,	,	PUNCT
gs-4321	966	18	gabunia	gabunia	NOUN
gs-4321	966	19	,	,	PUNCT
gs-4321	966	20	l.	l.	PROPN
gs-4321	966	21	,	,	PUNCT
gs-4321	966	22	giorgobiani	giorgobiani	PROPN
gs-4321	966	23	,	,	PUNCT
gs-4321	966	24	m.	m.	NOUN
gs-4321	966	25	(	(	PUNCT
gs-4321	966	26	2023	2023	NUM
gs-4321	966	27	)	)	PUNCT
gs-4321	966	28	.	.	PUNCT
gs-4321	967	1	manifestation	manifestation	NOUN
gs-4321	967	2	of	of	ADP
gs-4321	967	3	the	the	DET
gs-4321	967	4	particularities	particularity	NOUN
gs-4321	967	5	of	of	ADP
gs-4321	967	6	the	the	DET
gs-4321	967	7	usage	usage	NOUN
gs-4321	967	8	features	feature	NOUN
gs-4321	967	9	of	of	ADP
gs-4321	967	10	monoclonal	monoclonal	NOUN
gs-4321	967	11	antibodies	antibody	NOUN
gs-4321	967	12	in	in	ADP
gs-4321	967	13	various	various	ADJ
gs-4321	967	14	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-4321	967	15	applications	application	NOUN
gs-4321	967	16	.	.	PUNCT
gs-4321	968	1	experimental	experimental	ADJ
gs-4321	968	2	and	and	CCONJ
gs-4321	968	3	clinical	clinical	ADJ
gs-4321	968	4	medicine	medicine	NOUN
gs-4321	968	5	georgia	georgia	PROPN
gs-4321	968	6	,	,	PUNCT
gs-4321	968	7	(	(	PUNCT
gs-4321	968	8	4	4	NUM
gs-4321	968	9	)	)	PUNCT
gs-4321	968	10	,	,	PUNCT
gs-4321	968	11	52–57	52–57	NUM
gs-4321	968	12	.	.	PUNCT
gs-4321	969	1	https://doi.org/10.52340/jecm.2023.04.14	https://doi.org/10.52340/jecm.2023.04.14	X
gs-4321	969	2	sulashvili	sulashvili	NOUN
gs-4321	969	3	,	,	PUNCT
gs-4321	969	4	n.	n.	NOUN
gs-4321	969	5	,	,	PUNCT
gs-4321	969	6	gorgaslidze	gorgaslidze	PROPN
gs-4321	969	7	,	,	PUNCT
gs-4321	969	8	n.	n.	NOUN
gs-4321	969	9	,	,	PUNCT
gs-4321	969	10	gabunia	gabunia	NOUN
gs-4321	969	11	,	,	PUNCT
gs-4321	969	12	l.	l.	PROPN
gs-4321	969	13	(	(	PUNCT
gs-4321	969	14	2024	2024	NUM
gs-4321	969	15	)	)	PUNCT
gs-4321	969	16	.	.	PUNCT
gs-4321	970	1	manifestation	manifestation	NOUN
gs-4321	970	2	of	of	ADP
gs-4321	970	3	the	the	DET
gs-4321	970	4	particularities	particularity	NOUN
gs-4321	970	5	of	of	ADP
gs-4321	970	6	some	some	DET
gs-4321	970	7	key	key	ADJ
gs-4321	970	8	issue	issue	NOUN
gs-4321	970	9	aspects	aspect	NOUN
gs-4321	970	10	of	of	ADP
gs-4321	970	11	new	new	ADJ
gs-4321	970	12	immunotherapy	immunotherapy	NOUN
gs-4321	970	13	challenges	challenge	NOUN
gs-4321	970	14	and	and	CCONJ
gs-4321	970	15	perspectives	perspective	NOUN
gs-4321	970	16	by	by	ADP
gs-4321	970	17	car	car	NOUN
gs-4321	970	18	-	-	PUNCT
gs-4321	970	19	t	t	NOUN
gs-4321	970	20	cell	cell	NOUN
gs-4321	970	21	therapy	therapy	NOUN
gs-4321	970	22	.	.	PUNCT
gs-4321	971	1	experimental	experimental	ADJ
gs-4321	971	2	and	and	CCONJ
gs-4321	971	3	clinical	clinical	ADJ
gs-4321	971	4	medicine	medicine	NOUN
gs-4321	971	5	georgia	georgia	PROPN
gs-4321	971	6	,	,	PUNCT
gs-4321	971	7	(	(	PUNCT
gs-4321	971	8	4	4	NUM
gs-4321	971	9	)	)	PUNCT
gs-4321	971	10	,	,	PUNCT
gs-4321	971	11	119–121	119–121	NUM
gs-4321	971	12	.	.	PUNCT
gs-4321	972	1	https://doi.org/10.52340/jecm.2024.04.32	https://doi.org/10.52340/jecm.2024.04.32	PROPN
gs-4321	972	2	.	.	PUNCT
gs-4321	973	1	sulashvili	sulashvili	PROPN
gs-4321	973	2	n	n	CCONJ
gs-4321	973	3	,	,	PUNCT
gs-4321	973	4	nimangre	nimangre	PROPN
gs-4321	973	5	rr	rr	PROPN
gs-4321	973	6	.	.	PUNCT
gs-4321	974	1	manifestation	manifestation	NOUN
gs-4321	974	2	of	of	ADP
gs-4321	974	3	some	some	DET
gs-4321	974	4	aspects	aspect	NOUN
gs-4321	974	5	of	of	ADP
gs-4321	974	6	cardiovascular	cardiovascular	ADJ
gs-4321	974	7	diseases	disease	NOUN
gs-4321	974	8	,	,	PUNCT
gs-4321	974	9	implications	implication	NOUN
gs-4321	974	10	,	,	PUNCT
gs-4321	974	11	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-4321	974	12	strategies	strategy	NOUN
gs-4321	974	13	,	,	PUNCT
gs-4321	974	14	effects	effect	NOUN
gs-4321	974	15	,	,	PUNCT
gs-4321	974	16	impacts	impact	NOUN
gs-4321	974	17	and	and	CCONJ
gs-4321	974	18	potential	potential	ADJ
gs-4321	974	19	hazards	hazard	NOUN
gs-4321	974	20	in	in	ADP
gs-4321	974	21	general	general	ADJ
gs-4321	974	22	.	.	PUNCT
gs-4321	975	1	jr	jr	PROPN
gs-4321	975	2	.	.	PROPN
gs-4321	975	3	2025	2025	NUM
gs-4321	975	4	feb	feb	NOUN
gs-4321	975	5	.	.	PUNCT
gs-4321	976	1	7;3(1):1	7;3(1):1	NUM
gs-4321	976	2	-	-	SYM
gs-4321	976	3	27	27	NUM
gs-4321	976	4	.	.	PUNCT
gs-4321	977	1	available	available	ADJ
gs-4321	977	2	from	from	ADP
gs-4321	977	3	:	:	PUNCT
gs-4321	977	4	https://journals.4science.ge/index.php/jr/article/view/3393	https://journals.4science.ge/index.php/jr/article/view/3393	PROPN
gs-4321	977	5	.	.	PUNCT
gs-4321	978	1	aphkhazava	aphkhazava	PROPN
gs-4321	978	2	,	,	PUNCT
gs-4321	978	3	d.	d.	PROPN
gs-4321	978	4	,	,	PUNCT
gs-4321	978	5	tuphinashvili	tuphinashvili	NOUN
gs-4321	978	6	,	,	PUNCT
gs-4321	978	7	t.	t.	NOUN
gs-4321	978	8	,	,	PUNCT
gs-4321	978	9	sulashvili	sulashvili	NOUN
gs-4321	978	10	,	,	PUNCT
gs-4321	978	11	n.(2023	n.(2023	NOUN
gs-4321	978	12	)	)	PUNCT
gs-4321	978	13	.	.	PUNCT
gs-4321	979	1	the	the	DET
gs-4321	979	2	features	feature	NOUN
gs-4321	979	3	and	and	CCONJ
gs-4321	979	4	role	role	NOUN
gs-4321	979	5	of	of	ADP
gs-4321	979	6	shp2	shp2	ADJ
gs-4321	979	7	protein	protein	NOUN
gs-4321	979	8	in	in	ADP
gs-4321	979	9	postnatal	postnatal	ADJ
gs-4321	979	10	muscle	muscle	NOUN
gs-4321	979	11	development	development	NOUN
gs-4321	979	12	.	.	PUNCT
gs-4321	980	1	scientific	scientific	ADJ
gs-4321	980	2	journal	journal	NOUN
gs-4321	980	3	„	„	PUNCT
gs-4321	980	4	spectri	spectri	NOUN
gs-4321	980	5	“	"	PUNCT
gs-4321	980	6	,	,	PUNCT
gs-4321	980	7	1	1	X
gs-4321	980	8	.	.	PUNCT
gs-4321	981	1	https://doi.org/10.52340/spectri.2023.01	https://doi.org/10.52340/spectri.2023.01	DET
gs-4321	981	2	sulashvili	sulashvili	NOUN
gs-4321	981	3	n	n	CCONJ
gs-4321	981	4	,	,	PUNCT
gs-4321	981	5	davitashvili	davitashvili	PROPN
gs-4321	981	6	m	m	PROPN
gs-4321	981	7	,	,	PUNCT
gs-4321	981	8	gorgaslidze	gorgaslidze	ADJ
gs-4321	981	9	n	n	CCONJ
gs-4321	981	10	,	,	PUNCT
gs-4321	981	11	gabunia	gabunia	NOUN
gs-4321	981	12	l.	l.	NOUN
gs-4321	981	13	the	the	DET
gs-4321	981	14	scientific	scientific	ADJ
gs-4321	981	15	discussion	discussion	NOUN
gs-4321	981	16	of	of	ADP
gs-4321	981	17	some	some	DET
gs-4321	981	18	issues	issue	NOUN
gs-4321	981	19	of	of	ADP
gs-4321	981	20	features	feature	NOUN
gs-4321	981	21	and	and	CCONJ
gs-4321	981	22	challenges	challenge	NOUN
gs-4321	981	23	of	of	ADP
gs-4321	981	24	using	use	VERB
gs-4321	981	25	of	of	ADP
gs-4321	981	26	car	car	NOUN
gs-4321	981	27	-	-	PUNCT
gs-4321	981	28	t	t	NOUN
gs-4321	981	29	cells	cell	NOUN
gs-4321	981	30	in	in	ADP
gs-4321	981	31	immunotherapy	immunotherapy	NOUN
gs-4321	981	32	.	.	PUNCT
gs-4321	982	1	gs	gs	PROPN
gs-4321	982	2	2024	2024	NUM
gs-4321	982	3	;	;	PUNCT
gs-4321	982	4	6(4):263	6(4):263	NUM
gs-4321	982	5	-	-	SYM
gs-4321	982	6	90	90	NUM
gs-4321	982	7	.	.	PUNCT
gs-4321	983	1	https://journals.4science.ge/index.php/gs/article/view/3214	https://journals.4science.ge/index.php/gs/article/view/3214	PROPN
gs-4321	983	2	aphkhazava	aphkhazava	PROPN
gs-4321	983	3	,	,	PUNCT
gs-4321	983	4	david	david	PROPN
gs-4321	983	5	,	,	PUNCT
gs-4321	983	6	nodar	nodar	NOUN
gs-4321	983	7	sulashvili	sulashvili	NOUN
gs-4321	983	8	,	,	PUNCT
gs-4321	983	9	and	and	CCONJ
gs-4321	983	10	jaba	jaba	PROPN
gs-4321	983	11	tkemaladze	tkemaladze	PROPN
gs-4321	983	12	.	.	PUNCT
gs-4321	984	1	2025	2025	NUM
gs-4321	984	2	.	.	PUNCT
gs-4321	985	1	“	"	PUNCT
gs-4321	985	2	stem	stem	NOUN
gs-4321	985	3	cell	cell	NOUN
gs-4321	985	4	systems	system	NOUN
gs-4321	985	5	and	and	CCONJ
gs-4321	985	6	regeneration	regeneration	NOUN
gs-4321	985	7	”	"	PUNCT
gs-4321	985	8	.	.	PUNCT
gs-4321	986	1	georgian	georgian	PROPN
gs-4321	986	2	scientists	scientist	NOUN
gs-4321	986	3	7	7	NUM
gs-4321	986	4	(	(	PUNCT
gs-4321	986	5	1):271	1):271	NUM
gs-4321	986	6	-	-	SYM
gs-4321	986	7	319	319	NUM
gs-4321	986	8	.	.	PUNCT
gs-4321	987	1	https://doi.org/10.52340/gs.2025.07.01.26	https://doi.org/10.52340/gs.2025.07.01.26	VERB
gs-4321	987	2	.	.	PUNCT
gs-4321	988	1	relling	relle	VERB
gs-4321	988	2	,	,	PUNCT
gs-4321	988	3	mary	mary	PROPN
gs-4321	988	4	v.	v.	PROPN
gs-4321	988	5	,	,	PUNCT
gs-4321	988	6	and	and	CCONJ
gs-4321	988	7	william	william	PROPN
gs-4321	988	8	e.	e.	PROPN
gs-4321	988	9	evans	evans	PROPN
gs-4321	988	10	.	.	PROPN
gs-4321	988	11	2015	2015	NUM
gs-4321	988	12	.	.	PUNCT
gs-4321	989	1	“	"	PUNCT
gs-4321	989	2	pharmacogenomics	pharmacogenomic	NOUN
gs-4321	989	3	in	in	ADP
gs-4321	989	4	the	the	DET
gs-4321	989	5	clinic	clinic	NOUN
gs-4321	989	6	.	.	PUNCT
gs-4321	989	7	”	"	PUNCT
gs-4321	990	1	nature	nature	NOUN
gs-4321	990	2	526	526	NUM
gs-4321	990	3	(	(	PUNCT
gs-4321	990	4	7573	7573	NUM
gs-4321	990	5	):	):	PUNCT
gs-4321	990	6	343–50	343–50	NUM
gs-4321	990	7	.	.	PUNCT
gs-4321	991	1	aphkhazava	aphkhazava	PROPN
gs-4321	991	2	,	,	PUNCT
gs-4321	991	3	david	david	PROPN
gs-4321	991	4	,	,	PUNCT
gs-4321	991	5	tamar	tamar	PROPN
gs-4321	991	6	tuphinashvili	tuphinashvili	PROPN
gs-4321	991	7	,	,	PUNCT
gs-4321	991	8	nodar	nodar	NOUN
gs-4321	991	9	sulashvili	sulashvili	NOUN
gs-4321	991	10	.	.	PUNCT
gs-4321	992	1	2023	2023	NUM
gs-4321	992	2	.	.	PUNCT
gs-4321	993	1	“	"	PUNCT
gs-4321	993	2	the	the	DET
gs-4321	993	3	features	feature	NOUN
gs-4321	993	4	and	and	CCONJ
gs-4321	993	5	role	role	NOUN
gs-4321	993	6	of	of	ADP
gs-4321	993	7	shp2	shp2	ADJ
gs-4321	993	8	protein	protein	NOUN
gs-4321	993	9	in	in	ADP
gs-4321	993	10	postnatal	postnatal	ADJ
gs-4321	993	11	muscle	muscle	NOUN
gs-4321	993	12	development	development	NOUN
gs-4321	993	13	”	"	PUNCT
gs-4321	993	14	.	.	PUNCT
gs-4321	994	1	scientific	scientific	ADJ
gs-4321	994	2	journal	journal	NOUN
gs-4321	994	3	„	„	PUNCT
gs-4321	994	4	spectri	spectri	ADJ
gs-4321	994	5	“	"	PUNCT
gs-4321	994	6	1	1	NUM
gs-4321	994	7	(	(	PUNCT
gs-4321	994	8	march	march	PROPN
gs-4321	994	9	)	)	PUNCT
gs-4321	994	10	.	.	PUNCT
gs-4321	995	1	https://doi.org/10.52340/spectri.2023.01	https://doi.org/10.52340/spectri.2023.01	PROPN
gs-4321	995	2	.	.	PUNCT
gs-4321	996	1	sulashvili	sulashvili	PROPN
gs-4321	996	2	n	n	CCONJ
gs-4321	996	3	,	,	PUNCT
gs-4321	996	4	gorgaslidze	gorgaslidze	ADJ
gs-4321	996	5	n	n	CCONJ
gs-4321	996	6	,	,	PUNCT
gs-4321	996	7	gabunia	gabunia	NOUN
gs-4321	996	8	l	l	NOUN
gs-4321	996	9	,	,	PUNCT
gs-4321	996	10	giorgobiani	giorgobiani	ADJ
gs-4321	996	11	m.	m.	NOUN
gs-4321	996	12	manifestation	manifestation	NOUN
gs-4321	996	13	of	of	ADP
gs-4321	996	14	the	the	DET
gs-4321	996	15	particularities	particularity	NOUN
gs-4321	996	16	of	of	ADP
gs-4321	996	17	the	the	DET
gs-4321	996	18	usage	usage	NOUN
gs-4321	996	19	features	feature	NOUN
gs-4321	996	20	of	of	ADP
gs-4321	996	21	monoclonal	monoclonal	NOUN
gs-4321	996	22	antibodies	antibody	NOUN
gs-4321	996	23	in	in	ADP
gs-4321	996	24	various	various	ADJ
gs-4321	996	25	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-4321	996	26	applications	application	NOUN
gs-4321	996	27	.	.	PUNCT
gs-4321	997	1	jecmg	jecmg	NOUN
gs-4321	997	2	2023	2023	NUM
gs-4321	997	3	nov	nov	PROPN
gs-4321	997	4	.	.	PROPN
gs-4321	997	5	26;(4):52	26;(4):52	PROPN
gs-4321	997	6	-	-	SYM
gs-4321	997	7	7	7	NUM
gs-4321	997	8	.	.	PUNCT
gs-4321	997	9	available	available	ADJ
gs-4321	997	10	from	from	ADP
gs-4321	997	11	:	:	PUNCT
gs-4321	997	12	https://journals.4science.ge/index.php/jecm/article/view/2413	https://journals.4science.ge/index.php/jecm/article/view/2413	PROPN
gs-4321	997	13	.	.	PROPN
gs-4321	997	14	aphkhazava	aphkhazava	PROPN
gs-4321	997	15	,	,	PUNCT
gs-4321	997	16	david	david	PROPN
gs-4321	997	17	,	,	PUNCT
gs-4321	997	18	nodar	nodar	PROPN
gs-4321	997	19	sulashvili	sulashvili	NOUN
gs-4321	997	20	,	,	PUNCT
gs-4321	997	21	ia	ia	PROPN
gs-4321	997	22	egnatievi	egnatievi	PROPN
gs-4321	997	23	,	,	PUNCT
gs-4321	997	24	manana	manana	PROPN
gs-4321	997	25	giorgobiani	giorgobiani	PROPN
gs-4321	997	26	.	.	PUNCT
gs-4321	998	1	2024	2024	NUM
gs-4321	998	2	.	.	PUNCT
gs-4321	999	1	“	"	PUNCT
gs-4321	999	2	derivation	derivation	NOUN
gs-4321	999	3	of	of	ADP
gs-4321	999	4	ampa	ampa	NOUN
gs-4321	999	5	receptor	receptor	NOUN
gs-4321	999	6	glua1	glua1	NOUN
gs-4321	999	7	subunits	subunit	NOUN
gs-4321	999	8	in	in	ADP
gs-4321	999	9	mice	mouse	NOUN
gs-4321	999	10	from	from	ADP
gs-4321	999	11	exosomes	exosome	NOUN
gs-4321	999	12	modulates	modulate	NOUN
gs-4321	999	13	inflammatory	inflammatory	ADJ
gs-4321	999	14	pain	pain	NOUN
gs-4321	999	15	”	"	PUNCT
gs-4321	999	16	.	.	PUNCT
gs-4321	1000	1	scientific	scientific	ADJ
gs-4321	1000	2	journal	journal	NOUN
gs-4321	1000	3	„	„	PUNCT
gs-4321	1000	4	spectri	spectri	ADJ
gs-4321	1000	5	“	"	PUNCT
gs-4321	1000	6	9	9	NUM
gs-4321	1000	7	(	(	PUNCT
gs-4321	1000	8	1	1	NUM
gs-4321	1000	9	)	)	PUNCT
gs-4321	1000	10	.	.	PUNCT
gs-4321	1001	1	https://doi.org/10.52340/spectri.2024.09.01.05	https://doi.org/10.52340/spectri.2024.09.01.05	PROPN
gs-4321	1001	2	.	.	PROPN
gs-4321	1001	3	aphkhazava	aphkhazava	PROPN
gs-4321	1001	4	,	,	PUNCT
gs-4321	1001	5	david	david	PROPN
gs-4321	1001	6	,	,	PUNCT
gs-4321	1001	7	nodar	nodar	PROPN
gs-4321	1001	8	sulashvili	sulashvili	NOUN
gs-4321	1001	9	,	,	PUNCT
gs-4321	1001	10	ia	ia	PROPN
gs-4321	1001	11	egnatievi	egnatievi	PROPN
gs-4321	1001	12	,	,	PUNCT
gs-4321	1001	13	tamar	tamar	PROPN
gs-4321	1001	14	tupinashvili	tupinashvili	NOUN
gs-4321	1001	15	.	.	PUNCT
gs-4321	1002	1	2024	2024	NUM
gs-4321	1002	2	.	.	PUNCT
gs-4321	1003	1	“	"	PUNCT
gs-4321	1003	2	dynamic	dynamic	ADJ
gs-4321	1003	3	tumor	tumor	NOUN
gs-4321	1003	4	microenvironment	microenvironment	NOUN
gs-4321	1003	5	theory	theory	NOUN
gs-4321	1003	6	:	:	PUNCT
gs-4321	1003	7	a	a	DET
gs-4321	1003	8	multifaceted	multifaceted	ADJ
gs-4321	1003	9	approach	approach	NOUN
gs-4321	1003	10	to	to	ADP
gs-4321	1003	11	tumor	tumor	NOUN
gs-4321	1003	12	georgian	georgian	NOUN
gs-4321	1003	13	scientists/	scientists/	NUM
gs-4321	1003	14	.	.	PUNCT
gs-4321	1004	1	7	7	NUM
gs-4321	1004	2	n	n	DET
gs-4321	1004	3	4	4	NUM
gs-4321	1004	4	,	,	PUNCT
gs-4321	1004	5	2025	2025	NUM
gs-4321	1004	6	385	385	NUM
gs-4321	1004	7	research	research	NOUN
gs-4321	1004	8	and	and	CCONJ
gs-4321	1004	9	biochemistry	biochemistry	NOUN
gs-4321	1004	10	”	"	PUNCT
gs-4321	1004	11	.	.	PUNCT
gs-4321	1005	1	scientific	scientific	ADJ
gs-4321	1005	2	journal	journal	NOUN
gs-4321	1005	3	„	„	PUNCT
gs-4321	1005	4	spectri	spectri	ADJ
gs-4321	1005	5	“	"	PUNCT
gs-4321	1005	6	9	9	NUM
gs-4321	1005	7	(	(	PUNCT
gs-4321	1005	8	1	1	NUM
gs-4321	1005	9	)	)	PUNCT
gs-4321	1005	10	.	.	PUNCT
gs-4321	1006	1	https://doi.org/10.52340/spectri.2024.09.01.06	https://doi.org/10.52340/spectri.2024.09.01.06	NOUN
gs-4321	1006	2	.	.	PROPN
gs-4321	1006	3	gorgaslidze	gorgaslidze	PROPN
gs-4321	1006	4	,	,	PUNCT
gs-4321	1006	5	nana	nana	PROPN
gs-4321	1006	6	,	,	PUNCT
gs-4321	1006	7	nodar	nodar	NOUN
gs-4321	1006	8	sulashvili	sulashvili	NOUN
gs-4321	1006	9	,	,	PUNCT
gs-4321	1006	10	luiza	luiza	PROPN
gs-4321	1006	11	gabunia	gabunia	NOUN
gs-4321	1006	12	.	.	PUNCT
gs-4321	1007	1	2023	2023	NUM
gs-4321	1007	2	.	.	PUNCT
gs-4321	1008	1	“	"	PUNCT
gs-4321	1008	2	the	the	DET
gs-4321	1008	3	singularities	singularity	NOUN
gs-4321	1008	4	of	of	ADP
gs-4321	1008	5	temozolomide	temozolomide	NOUN
gs-4321	1008	6	pharmacotherapeutic	pharmacotherapeutic	ADJ
gs-4321	1008	7	effects	effect	NOUN
gs-4321	1008	8	in	in	ADP
gs-4321	1008	9	brain	brain	NOUN
gs-4321	1008	10	tumor	tumor	NOUN
gs-4321	1008	11	therapeutic	therapeutic	ADJ
gs-4321	1008	12	applications	application	NOUN
gs-4321	1008	13	”	"	PUNCT
gs-4321	1008	14	.	.	PUNCT
gs-4321	1009	1	experimental	experimental	ADJ
gs-4321	1009	2	and	and	CCONJ
gs-4321	1009	3	clinical	clinical	ADJ
gs-4321	1009	4	medicine	medicine	NOUN
gs-4321	1009	5	georgia	georgia	PROPN
gs-4321	1009	6	,	,	PUNCT
gs-4321	1009	7	no	no	INTJ
gs-4321	1009	8	.	.	NOUN
gs-4321	1009	9	4	4	NUM
gs-4321	1009	10	(	(	PUNCT
gs-4321	1009	11	november):6266	november):6266	NOUN
gs-4321	1009	12	.	.	PUNCT
gs-4321	1010	1	https://doi.org/10.52340/jecm.2023.04.16	https://doi.org/10.52340/jecm.2023.04.16	PROPN
gs-4321	1010	2	.	.	PUNCT
gs-4321	1011	1	sulashvili	sulashvili	PROPN
gs-4321	1011	2	n	n	CCONJ
gs-4321	1011	3	,	,	PUNCT
gs-4321	1011	4	gorgaslidze	gorgaslidze	ADJ
gs-4321	1011	5	n	n	CCONJ
gs-4321	1011	6	,	,	PUNCT
gs-4321	1011	7	gabunia	gabunia	NOUN
gs-4321	1011	8	l	l	NOUN
gs-4321	1011	9	,	,	PUNCT
gs-4321	1011	10	beglaryan	beglaryan	PROPN
gs-4321	1011	11	m	m	PROPN
gs-4321	1011	12	,	,	PUNCT
gs-4321	1011	13	alavidze	alavidze	PROPN
gs-4321	1011	14	n	n	CCONJ
gs-4321	1011	15	,	,	PUNCT
gs-4321	1011	16	et	et	PROPN
gs-4321	1011	17	al	al	PROPN
gs-4321	1011	18	.	.	PUNCT
gs-4321	1012	1	the	the	DET
gs-4321	1012	2	scientific	scientific	ADJ
gs-4321	1012	3	discussion	discussion	NOUN
gs-4321	1012	4	of	of	ADP
gs-4321	1012	5	some	some	DET
gs-4321	1012	6	issues	issue	NOUN
gs-4321	1012	7	of	of	ADP
gs-4321	1012	8	features	feature	NOUN
gs-4321	1012	9	and	and	CCONJ
gs-4321	1012	10	challenges	challenge	NOUN
gs-4321	1012	11	of	of	ADP
gs-4321	1012	12	using	use	VERB
gs-4321	1012	13	of	of	ADP
gs-4321	1012	14	cart	cart	NOUN
gs-4321	1012	15	cells	cell	NOUN
gs-4321	1012	16	in	in	ADP
gs-4321	1012	17	immunotherapy	immunotherapy	NOUN
gs-4321	1012	18	.	.	PUNCT
gs-4321	1013	1	gs	gs	PROPN
gs-4321	1013	2	.	.	PROPN
gs-4321	1014	1	2024	2024	NUM
gs-4321	1014	2	nov	nov	PROPN
gs-4321	1014	3	.	.	PROPN
gs-4321	1014	4	26;6(4):263	26;6(4):263	NUM
gs-4321	1014	5	-	-	SYM
gs-4321	1014	6	90	90	NUM
gs-4321	1014	7	.	.	PUNCT
gs-4321	1014	8	available	available	ADJ
gs-4321	1014	9	from	from	ADP
gs-4321	1014	10	:	:	PUNCT
gs-4321	1014	11	https://journals.4science.ge/index.php/gs/article/view/3214	https://journals.4science.ge/index.php/gs/article/view/3214	X
gs-4321	1014	12	.	.	PUNCT
gs-4321	1015	1	qiu	qiu	PROPN
gs-4321	1015	2	,	,	PUNCT
gs-4321	1015	3	x.	x.	PROPN
gs-4321	1015	4	,	,	PUNCT
gs-4321	1015	5	zhang	zhang	PROPN
gs-4321	1015	6	,	,	PUNCT
gs-4321	1015	7	y.	y.	PROPN
gs-4321	1015	8	,	,	PUNCT
gs-4321	1015	9	martin	martin	PROPN
gs-4321	1015	10	-	-	PUNCT
gs-4321	1015	11	rufino	rufino	PROPN
gs-4321	1015	12	,	,	PUNCT
gs-4321	1015	13	j.	j.	PROPN
gs-4321	1015	14	d.	d.	PROPN
gs-4321	1015	15	,	,	PUNCT
gs-4321	1015	16	(	(	PUNCT
gs-4321	1015	17	2022	2022	NUM
gs-4321	1015	18	)	)	PUNCT
gs-4321	1015	19	.	.	PUNCT
gs-4321	1016	1	mapping	map	VERB
gs-4321	1016	2	transcriptomic	transcriptomic	ADJ
gs-4321	1016	3	vector	vector	NOUN
gs-4321	1016	4	fields	field	NOUN
gs-4321	1016	5	of	of	ADP
gs-4321	1016	6	single	single	ADJ
gs-4321	1016	7	cells	cell	NOUN
gs-4321	1016	8	.	.	PUNCT
gs-4321	1017	1	cell	cell	NOUN
gs-4321	1017	2	,	,	PUNCT
gs-4321	1017	3	185(4	185(4	NUM
gs-4321	1017	4	)	)	PUNCT
gs-4321	1017	5	,	,	PUNCT
gs-4321	1017	6	690–711.e45	690–711.e45	NUM
gs-4321	1017	7	.	.	PUNCT
gs-4321	1018	1	quintanal	quintanal	ADJ
gs-4321	1018	2	-	-	PUNCT
gs-4321	1018	3	villalonga	villalonga	NOUN
gs-4321	1018	4	,	,	PUNCT
gs-4321	1018	5	á	á	PROPN
gs-4321	1018	6	.	.	PROPN
gs-4321	1018	7	,	,	PUNCT
gs-4321	1018	8	chan	chan	PROPN
gs-4321	1018	9	,	,	PUNCT
gs-4321	1018	10	j.	j.	PROPN
gs-4321	1018	11	m.	m.	PROPN
gs-4321	1018	12	,	,	PUNCT
gs-4321	1018	13	yu	yu	PROPN
gs-4321	1018	14	,	,	PUNCT
gs-4321	1018	15	h.	h.	PROPN
gs-4321	1018	16	(	(	PUNCT
gs-4321	1018	17	2020	2020	NUM
gs-4321	1018	18	)	)	PUNCT
gs-4321	1018	19	.	.	PUNCT
gs-4321	1019	1	lineage	lineage	NOUN
gs-4321	1019	2	plasticity	plasticity	NOUN
gs-4321	1019	3	in	in	ADP
gs-4321	1019	4	cancer	cancer	NOUN
gs-4321	1019	5	:	:	PUNCT
gs-4321	1019	6	a	a	DET
gs-4321	1019	7	shared	share	VERB
gs-4321	1019	8	pathway	pathway	NOUN
gs-4321	1019	9	of	of	ADP
gs-4321	1019	10	therapeutic	therapeutic	ADJ
gs-4321	1019	11	resistance	resistance	NOUN
gs-4321	1019	12	.	.	PUNCT
gs-4321	1020	1	nature	nature	NOUN
gs-4321	1020	2	reviews	review	VERB
gs-4321	1020	3	clinical	clinical	ADJ
gs-4321	1020	4	oncology	oncology	NOUN
gs-4321	1020	5	,	,	PUNCT
gs-4321	1020	6	17(6	17(6	NUM
gs-4321	1020	7	)	)	PUNCT
gs-4321	1020	8	,	,	PUNCT
gs-4321	1020	9	360–371	360–371	NUM
gs-4321	1020	10	.	.	PUNCT
gs-4321	1021	1	raj	raj	PROPN
gs-4321	1021	2	,	,	PUNCT
gs-4321	1021	3	a.	a.	PROPN
gs-4321	1021	4	,	,	PUNCT
gs-4321	1021	5	rifkin	rifkin	PROPN
gs-4321	1021	6	,	,	PUNCT
gs-4321	1021	7	s.	s.	PROPN
gs-4321	1021	8	a.	a.	PROPN
gs-4321	1021	9	,	,	PUNCT
gs-4321	1021	10	andersen	andersen	PROPN
gs-4321	1021	11	,	,	PUNCT
gs-4321	1021	12	e.	e.	PROPN
gs-4321	1021	13	,	,	PUNCT
gs-4321	1021	14	&	&	CCONJ
gs-4321	1021	15	van	van	PROPN
gs-4321	1021	16	oudenaarden	oudenaarden	PROPN
gs-4321	1021	17	,	,	PUNCT
gs-4321	1021	18	a.	a.	NOUN
gs-4321	1021	19	(	(	PUNCT
gs-4321	1021	20	2021	2021	NUM
gs-4321	1021	21	)	)	PUNCT
gs-4321	1021	22	.	.	PUNCT
gs-4321	1022	1	variability	variability	NOUN
gs-4321	1022	2	in	in	ADP
gs-4321	1022	3	gene	gene	NOUN
gs-4321	1022	4	expression	expression	NOUN
gs-4321	1022	5	underlies	underlie	VERB
gs-4321	1022	6	incomplete	incomplete	ADJ
gs-4321	1022	7	penetrance	penetrance	NOUN
gs-4321	1022	8	.	.	PUNCT
gs-4321	1023	1	nature	nature	NOUN
gs-4321	1023	2	,	,	PUNCT
gs-4321	1023	3	463(7283	463(7283	PROPN
gs-4321	1023	4	)	)	PUNCT
gs-4321	1023	5	,	,	PUNCT
gs-4321	1023	6	913–918	913–918	NUM
gs-4321	1023	7	.	.	PUNCT