id	sid	tid	token	lemma	pos
gs-4426	1	1	georgian	georgian	PROPN
gs-4426	1	2	scientists/	scientists/	NUM
gs-4426	1	3	.	.	PUNCT
gs-4426	2	1	7	7	NUM
gs-4426	2	2	n	n	DET
gs-4426	2	3	4	4	NUM
gs-4426	2	4	,	,	PUNCT
gs-4426	2	5	2025	2025	NUM
gs-4426	2	6	593	593	NUM
gs-4426	2	7	georgian	georgian	ADJ
gs-4426	2	8	scientists	scientist	NOUN
gs-4426	2	9	vol	vol	NOUN
gs-4426	2	10	.	.	PUNCT
gs-4426	2	11	7	7	NUM
gs-4426	2	12	issue	issue	NOUN
gs-4426	2	13	4	4	NUM
gs-4426	2	14	,	,	PUNCT
gs-4426	2	15	2025	2025	NUM
gs-4426	2	16	https://doi.org/10.52340/gs.2025.07.04.42	https://doi.org/10.52340/gs.2025.07.04.42	NUM
gs-4426	2	17	the	the	DET
gs-4426	2	18	manifestation	manifestation	NOUN
gs-4426	2	19	of	of	ADP
gs-4426	2	20	features	feature	NOUN
gs-4426	2	21	of	of	ADP
gs-4426	2	22	gene	gene	NOUN
gs-4426	2	23	therapy	therapy	NOUN
gs-4426	2	24	advances	advance	VERB
gs-4426	2	25	:	:	PUNCT
gs-4426	2	26	a	a	DET
gs-4426	2	27	comprehensive	comprehensive	ADJ
gs-4426	2	28	discourse	discourse	NOUN
gs-4426	2	29	of	of	ADP
gs-4426	2	30	current	current	ADJ
gs-4426	2	31	progress	progress	NOUN
gs-4426	2	32	and	and	CCONJ
gs-4426	2	33	future	future	ADJ
gs-4426	2	34	directions	direction	NOUN
gs-4426	2	35	nodar	nodar	ADV
gs-4426	2	36	sulashvili1	sulashvili1	PROPN
gs-4426	2	37	,	,	PUNCT
gs-4426	2	38	naira	naira	PROPN
gs-4426	2	39	chichoyan2	chichoyan2	NOUN
gs-4426	2	40	,	,	PUNCT
gs-4426	2	41	vira	vira	PROPN
gs-4426	2	42	kravchenko3	kravchenko3	PROPN
gs-4426	2	43	,	,	PUNCT
gs-4426	2	44	irina	irina	PROPN
gs-4426	2	45	imerlishvili4	imerlishvili4	PROPN
gs-4426	2	46	,	,	PUNCT
gs-4426	2	47	luiza	luiza	PROPN
gs-4426	2	48	gabunia5	gabunia5	PROPN
gs-4426	2	49	,	,	PUNCT
gs-4426	2	50	nana	nana	PROPN
gs-4426	2	51	gorgaslidze6	gorgaslidze6	PROPN
gs-4426	2	52	,	,	PUNCT
gs-4426	2	53	maka	maka	PROPN
gs-4426	2	54	buleishvili7	buleishvili7	PROPN
gs-4426	2	55	,	,	PUNCT
gs-4426	2	56	marika	marika	PROPN
gs-4426	2	57	sulashvili8	sulashvili8	PROPN
gs-4426	2	58	,	,	PUNCT
gs-4426	2	59	rajkaran	rajkaran	NOUN
gs-4426	2	60	singh9	singh9	PROPN
gs-4426	2	61	,	,	PUNCT
gs-4426	2	62	deva	deva	PROPN
gs-4426	2	63	harsha	harsha	PROPN
gs-4426	2	64	uday	uday	PROPN
gs-4426	2	65	gundluru10	gundluru10	PROPN
gs-4426	2	66	,	,	PUNCT
gs-4426	2	67	david	david	PROPN
gs-4426	2	68	aphkhazava11	aphkhazava11	PROPN
gs-4426	2	69	1	1	NUM
gs-4426	2	70	.	.	PUNCT
gs-4426	3	1	md	md	PROPN
gs-4426	3	2	,	,	PUNCT
gs-4426	3	3	phd	phd	NOUN
gs-4426	3	4	,	,	PUNCT
gs-4426	3	5	doctor	doctor	NOUN
gs-4426	3	6	of	of	ADP
gs-4426	3	7	pharmaceutical	pharmaceutical	ADJ
gs-4426	3	8	and	and	CCONJ
gs-4426	3	9	pharmacological	pharmacological	ADJ
gs-4426	3	10	sciences	science	NOUN
gs-4426	3	11	in	in	ADP
gs-4426	3	12	medicine	medicine	NOUN
gs-4426	3	13	,	,	PUNCT
gs-4426	3	14	invited	invite	VERB
gs-4426	3	15	lecturer	lecturer	NOUN
gs-4426	3	16	(	(	PUNCT
gs-4426	3	17	invited	invite	VERB
gs-4426	3	18	professor	professor	NOUN
gs-4426	3	19	)	)	PUNCT
gs-4426	3	20	of	of	ADP
gs-4426	3	21	scientific	scientific	ADJ
gs-4426	3	22	research	research	NOUN
gs-4426	3	23	-	-	PUNCT
gs-4426	3	24	skills	skill	NOUN
gs-4426	3	25	center	center	NOUN
gs-4426	3	26	at	at	ADP
gs-4426	3	27	tbilisi	tbilisi	PROPN
gs-4426	3	28	state	state	PROPN
gs-4426	3	29	medical	medical	PROPN
gs-4426	3	30	university	university	PROPN
gs-4426	3	31	;	;	PUNCT
gs-4426	3	32	professor	professor	NOUN
gs-4426	3	33	of	of	ADP
gs-4426	3	34	medical	medical	ADJ
gs-4426	3	35	pharmacology	pharmacology	NOUN
gs-4426	3	36	of	of	ADP
gs-4426	3	37	faculty	faculty	NOUN
gs-4426	3	38	of	of	ADP
gs-4426	3	39	medicine	medicine	NOUN
gs-4426	3	40	at	at	ADP
gs-4426	3	41	georgian	georgian	PROPN
gs-4426	3	42	national	national	PROPN
gs-4426	3	43	university	university	PROPN
gs-4426	3	44	seu	seu	NOUN
gs-4426	3	45	;	;	PUNCT
gs-4426	3	46	professor	professor	NOUN
gs-4426	3	47	of	of	ADP
gs-4426	3	48	medical	medical	ADJ
gs-4426	3	49	and	and	CCONJ
gs-4426	3	50	clinical	clinical	ADJ
gs-4426	3	51	pharmacology	pharmacology	NOUN
gs-4426	3	52	of	of	ADP
gs-4426	3	53	international	international	ADJ
gs-4426	3	54	school	school	NOUN
gs-4426	3	55	of	of	ADP
gs-4426	3	56	medicine	medicine	NOUN
gs-4426	3	57	at	at	ADP
gs-4426	3	58	alte	alte	PROPN
gs-4426	3	59	university	university	PROPN
gs-4426	3	60	;	;	PUNCT
gs-4426	3	61	tbilisi	tbilisi	PROPN
gs-4426	3	62	,	,	PUNCT
gs-4426	3	63	georgia	georgia	PROPN
gs-4426	3	64	;	;	PUNCT
gs-4426	3	65	orcid	orcid	PROPN
gs-4426	3	66	https://orcid.org/0000-0002-9005-8577	https://orcid.org/0000-0002-9005-8577	PROPN
gs-4426	3	67	;	;	PUNCT
gs-4426	3	68	e	e	X
gs-4426	3	69	-	-	NOUN
gs-4426	3	70	mail	mail	NOUN
gs-4426	3	71	:	:	PUNCT
gs-4426	3	72	n.sulashvili@ug.edu.ge	n.sulashvili@ug.edu.ge	PROPN
gs-4426	3	73	2	2	NUM
gs-4426	3	74	.	.	PUNCT
gs-4426	3	75	md	md	PROPN
gs-4426	3	76	,	,	PUNCT
gs-4426	3	77	phd	phd	NOUN
gs-4426	3	78	,	,	PUNCT
gs-4426	3	79	doctor	doctor	NOUN
gs-4426	3	80	of	of	ADP
gs-4426	3	81	pharmaceutical	pharmaceutical	NOUN
gs-4426	3	82	sciences	science	NOUN
gs-4426	3	83	,	,	PUNCT
gs-4426	3	84	professor	professor	NOUN
gs-4426	3	85	of	of	ADP
gs-4426	3	86	yerevan	yerevan	PROPN
gs-4426	3	87	state	state	PROPN
gs-4426	3	88	medical	medical	PROPN
gs-4426	3	89	university	university	PROPN
gs-4426	3	90	after	after	ADP
gs-4426	3	91	mkhitar	mkhitar	NOUN
gs-4426	3	92	heratsi	heratsi	PROPN
gs-4426	3	93	,	,	PUNCT
gs-4426	3	94	head	head	NOUN
gs-4426	3	95	of	of	ADP
gs-4426	3	96	the	the	DET
gs-4426	3	97	department	department	NOUN
gs-4426	3	98	of	of	ADP
gs-4426	3	99	pharmacognosy	pharmacognosy	NOUN
gs-4426	3	100	,	,	PUNCT
gs-4426	3	101	yerevan	yerevan	PROPN
gs-4426	3	102	,	,	PUNCT
gs-4426	3	103	armenia	armenia	PROPN
gs-4426	3	104	.	.	PUNCT
gs-4426	4	1	https://orcid.org/0000-0003-3905-3372	https://orcid.org/0000-0003-3905-3372	PROPN
gs-4426	4	2	3	3	NUM
gs-4426	4	3	.	.	PUNCT
gs-4426	4	4	md	md	PROPN
gs-4426	4	5	,	,	PUNCT
gs-4426	4	6	phd	phd	PROPN
gs-4426	4	7	,	,	PUNCT
gs-4426	4	8	doctor	doctor	NOUN
gs-4426	4	9	of	of	ADP
gs-4426	4	10	biological	biological	ADJ
gs-4426	4	11	sciences	science	NOUN
gs-4426	4	12	,	,	PUNCT
gs-4426	4	13	academician	academician	NOUN
gs-4426	4	14	,	,	PUNCT
gs-4426	4	15	professor	professor	NOUN
gs-4426	4	16	,	,	PUNCT
gs-4426	4	17	head	head	NOUN
gs-4426	4	18	of	of	ADP
gs-4426	4	19	the	the	DET
gs-4426	4	20	biological	biological	ADJ
gs-4426	4	21	chemistry	chemistry	NOUN
gs-4426	4	22	department	department	NOUN
gs-4426	4	23	at	at	ADP
gs-4426	4	24	national	national	PROPN
gs-4426	4	25	university	university	PROPN
gs-4426	4	26	of	of	ADP
gs-4426	4	27	pharmacy	pharmacy	NOUN
gs-4426	4	28	of	of	ADP
gs-4426	4	29	ukraine	ukraine	NOUN
gs-4426	4	30	,	,	PUNCT
gs-4426	4	31	kharkiv	kharkiv	PROPN
gs-4426	4	32	,	,	PUNCT
gs-4426	4	33	ukraine	ukraine	NOUN
gs-4426	4	34	.	.	PUNCT
gs-4426	5	1	https://orcid.org/0000-0001-6335-2490	https://orcid.org/0000-0001-6335-2490	PROPN
gs-4426	5	2	4	4	NUM
gs-4426	5	3	.	.	X
gs-4426	5	4	phd	phd	NOUN
gs-4426	5	5	,	,	PUNCT
gs-4426	5	6	doctor	doctor	NOUN
gs-4426	5	7	of	of	ADP
gs-4426	5	8	law	law	NOUN
gs-4426	5	9	,	,	PUNCT
gs-4426	5	10	professor	professor	NOUN
gs-4426	5	11	,	,	PUNCT
gs-4426	5	12	rector	rector	NOUN
gs-4426	5	13	of	of	ADP
gs-4426	5	14	bau	bau	PROPN
gs-4426	5	15	international	international	PROPN
gs-4426	5	16	university	university	PROPN
gs-4426	5	17	batumi	batumi	NOUN
gs-4426	5	18	;	;	PUNCT
gs-4426	5	19	professor	professor	NOUN
gs-4426	5	20	of	of	ADP
gs-4426	5	21	bau	bau	PROPN
gs-4426	5	22	international	international	PROPN
gs-4426	5	23	university	university	PROPN
gs-4426	5	24	batumi	batumi	NOUN
gs-4426	5	25	;	;	PUNCT
gs-4426	5	26	professor	professor	NOUN
gs-4426	5	27	at	at	ADP
gs-4426	5	28	the	the	DET
gs-4426	5	29	international	international	ADJ
gs-4426	5	30	black	black	PROPN
gs-4426	5	31	sea	sea	PROPN
gs-4426	5	32	university	university	NOUN
gs-4426	5	33	,	,	PUNCT
gs-4426	5	34	batumi	batumi	NOUN
gs-4426	5	35	-	-	PUNCT
gs-4426	5	36	tbilisi	tbilisi	ADJ
gs-4426	5	37	,	,	PUNCT
gs-4426	5	38	georgia	georgia	PROPN
gs-4426	5	39	;	;	PUNCT
gs-4426	5	40	5	5	NUM
gs-4426	5	41	.	.	X
gs-4426	5	42	md	md	PROPN
gs-4426	5	43	,	,	PUNCT
gs-4426	5	44	phd	phd	NOUN
gs-4426	5	45	,	,	PUNCT
gs-4426	5	46	doctor	doctor	NOUN
gs-4426	5	47	of	of	ADP
gs-4426	5	48	medical	medical	ADJ
gs-4426	5	49	sciences	sciences	PROPN
gs-4426	5	50	,	,	PUNCT
gs-4426	5	51	professor	professor	NOUN
gs-4426	5	52	,	,	PUNCT
gs-4426	5	53	director	director	NOUN
gs-4426	5	54	of	of	ADP
gs-4426	5	55	the	the	DET
gs-4426	5	56	scientific	scientific	ADJ
gs-4426	5	57	research	research	NOUN
gs-4426	5	58	-	-	PUNCT
gs-4426	5	59	skills	skill	NOUN
gs-4426	5	60	center	center	NOUN
gs-4426	5	61	at	at	ADP
gs-4426	5	62	tbilisi	tbilisi	PROPN
gs-4426	5	63	state	state	PROPN
gs-4426	5	64	medical	medical	PROPN
gs-4426	5	65	university	university	PROPN
gs-4426	5	66	,	,	PUNCT
gs-4426	5	67	professor	professor	NOUN
gs-4426	5	68	,	,	PUNCT
gs-4426	5	69	head	head	NOUN
gs-4426	5	70	of	of	ADP
gs-4426	5	71	the	the	DET
gs-4426	5	72	department	department	PROPN
gs-4426	5	73	of	of	ADP
gs-4426	5	74	medical	medical	ADJ
gs-4426	5	75	and	and	CCONJ
gs-4426	5	76	clinical	clinical	ADJ
gs-4426	5	77	pharmacology	pharmacology	NOUN
gs-4426	5	78	at	at	ADP
gs-4426	5	79	tbilisi	tbilisi	PROPN
gs-4426	5	80	state	state	PROPN
gs-4426	5	81	medical	medical	PROPN
gs-4426	5	82	university	university	PROPN
gs-4426	5	83	,	,	PUNCT
gs-4426	5	84	clinical	clinical	ADJ
gs-4426	5	85	pharmacologist	pharmacologist	NOUN
gs-4426	5	86	of	of	ADP
gs-4426	5	87	the	the	DET
gs-4426	5	88	first	first	ADJ
gs-4426	5	89	university	university	NOUN
gs-4426	5	90	clinic	clinic	NOUN
gs-4426	5	91	of	of	ADP
gs-4426	5	92	tsmu	tsmu	PROPN
gs-4426	5	93	,	,	PUNCT
gs-4426	5	94	tbilisi	tbilisi	PROPN
gs-4426	5	95	,	,	PUNCT
gs-4426	5	96	georgia	georgia	PROPN
gs-4426	5	97	;	;	PUNCT
gs-4426	5	98	https://orcid.org/0000-0003-0856-2684	https://orcid.org/0000-0003-0856-2684	PROPN
gs-4426	5	99	6	6	NUM
gs-4426	5	100	.	.	PUNCT
gs-4426	5	101	md	md	PROPN
gs-4426	5	102	,	,	PUNCT
gs-4426	5	103	phd	phd	NOUN
gs-4426	5	104	,	,	PUNCT
gs-4426	5	105	doctor	doctor	NOUN
gs-4426	5	106	of	of	ADP
gs-4426	5	107	pharmaceutical	pharmaceutical	NOUN
gs-4426	5	108	sciences	science	NOUN
gs-4426	5	109	,	,	PUNCT
gs-4426	5	110	academician	academician	NOUN
gs-4426	5	111	,	,	PUNCT
gs-4426	5	112	professor	professor	NOUN
gs-4426	5	113	of	of	ADP
gs-4426	5	114	tbilisi	tbilisi	PROPN
gs-4426	5	115	state	state	PROPN
gs-4426	5	116	medical	medical	PROPN
gs-4426	5	117	university	university	PROPN
gs-4426	5	118	,	,	PUNCT
gs-4426	5	119	head	head	NOUN
gs-4426	5	120	of	of	ADP
gs-4426	5	121	the	the	DET
gs-4426	5	122	department	department	NOUN
gs-4426	5	123	of	of	ADP
gs-4426	5	124	social	social	ADJ
gs-4426	5	125	and	and	CCONJ
gs-4426	5	126	clinical	clinical	ADJ
gs-4426	5	127	pharmacy	pharmacy	NOUN
gs-4426	5	128	,	,	PUNCT
gs-4426	5	129	tbilisi	tbilisi	PROPN
gs-4426	5	130	,	,	PUNCT
gs-4426	5	131	georgia	georgia	PROPN
gs-4426	5	132	;	;	PUNCT
gs-4426	5	133	https://orcid.org/0000-0002-4563-5224	https://orcid.org/0000-0002-4563-5224	PROPN
gs-4426	5	134	7	7	NUM
gs-4426	5	135	.	.	PUNCT
gs-4426	5	136	md	md	PROPN
gs-4426	5	137	,	,	PUNCT
gs-4426	5	138	phd	phd	NOUN
gs-4426	5	139	,	,	PUNCT
gs-4426	5	140	doctor	doctor	NOUN
gs-4426	5	141	of	of	ADP
gs-4426	5	142	medical	medical	ADJ
gs-4426	5	143	sciences	sciences	PROPN
gs-4426	5	144	,	,	PUNCT
gs-4426	5	145	professor	professor	NOUN
gs-4426	5	146	,	,	PUNCT
gs-4426	5	147	dean	dean	NOUN
gs-4426	5	148	of	of	ADP
gs-4426	5	149	faculty	faculty	NOUN
gs-4426	5	150	of	of	ADP
gs-4426	5	151	medicine	medicine	NOUN
gs-4426	5	152	of	of	ADP
gs-4426	5	153	bau	bau	PROPN
gs-4426	5	154	international	international	PROPN
gs-4426	5	155	university	university	PROPN
gs-4426	5	156	batumi	batumi	NOUN
gs-4426	5	157	,	,	PUNCT
gs-4426	5	158	professor	professor	NOUN
gs-4426	5	159	of	of	ADP
gs-4426	5	160	faculty	faculty	NOUN
gs-4426	5	161	of	of	ADP
gs-4426	5	162	medicine	medicine	NOUN
gs-4426	5	163	at	at	ADP
gs-4426	5	164	european	european	PROPN
gs-4426	5	165	university	university	PROPN
gs-4426	5	166	,	,	PUNCT
gs-4426	5	167	professor	professor	NOUN
gs-4426	5	168	of	of	ADP
gs-4426	5	169	faculty	faculty	NOUN
gs-4426	5	170	of	of	ADP
gs-4426	5	171	medicine	medicine	NOUN
gs-4426	5	172	at	at	ADP
gs-4426	5	173	georgian	georgian	PROPN
gs-4426	5	174	national	national	PROPN
gs-4426	5	175	university	university	PROPN
gs-4426	5	176	seu	seu	NOUN
gs-4426	5	177	,	,	PUNCT
gs-4426	5	178	professor	professor	NOUN
gs-4426	5	179	of	of	ADP
gs-4426	5	180	faculty	faculty	NOUN
gs-4426	5	181	of	of	ADP
gs-4426	5	182	medicine	medicine	NOUN
gs-4426	5	183	at	at	ADP
gs-4426	5	184	sulkhan	sulkhan	PROPN
gs-4426	5	185	-	-	PUNCT
gs-4426	5	186	saba	saba	PROPN
gs-4426	5	187	orbeliani	orbeliani	PROPN
gs-4426	5	188	university	university	PROPN
gs-4426	5	189	,	,	PUNCT
gs-4426	5	190	invited	invite	VERB
gs-4426	5	191	professor	professor	NOUN
gs-4426	5	192	of	of	ADP
gs-4426	5	193	faculty	faculty	NOUN
gs-4426	5	194	of	of	ADP
gs-4426	5	195	healthcare	healthcare	PROPN
gs-4426	5	196	sciences	sciences	PROPN
gs-4426	5	197	at	at	ADP
gs-4426	5	198	east	east	PROPN
gs-4426	5	199	european	european	PROPN
gs-4426	5	200	university	university	PROPN
gs-4426	5	201	,	,	PUNCT
gs-4426	5	202	invited	invite	VERB
gs-4426	5	203	professor	professor	NOUN
gs-4426	5	204	of	of	ADP
gs-4426	5	205	faculty	faculty	NOUN
gs-4426	5	206	of	of	ADP
gs-4426	5	207	medicine	medicine	NOUN
gs-4426	5	208	at	at	ADP
gs-4426	5	209	caucasus	caucasus	PROPN
gs-4426	5	210	international	international	PROPN
gs-4426	5	211	university	university	PROPN
gs-4426	5	212	,	,	PUNCT
gs-4426	5	213	invited	invite	VERB
gs-4426	5	214	lecturer	lecturer	NOUN
gs-4426	5	215	of	of	ADP
gs-4426	5	216	tbilisi	tbilisi	PROPN
gs-4426	5	217	state	state	PROPN
gs-4426	5	218	medical	medical	PROPN
gs-4426	5	219	university	university	PROPN
gs-4426	5	220	,	,	PUNCT
gs-4426	5	221	tbilisi	tbilisi	PROPN
gs-4426	5	222	,	,	PUNCT
gs-4426	5	223	georgia	georgia	PROPN
gs-4426	5	224	;	;	PUNCT
gs-4426	5	225	https://orcid.org/0009-0004-2657-8473	https://orcid.org/0009-0004-2657-8473	PROPN
gs-4426	5	226	8	8	NUM
gs-4426	5	227	.	.	PUNCT
gs-4426	6	1	md	md	PROPN
gs-4426	6	2	,	,	PUNCT
gs-4426	6	3	doctor	doctor	NOUN
gs-4426	6	4	of	of	ADP
gs-4426	6	5	family	family	NOUN
gs-4426	6	6	medicine	medicine	NOUN
gs-4426	6	7	,	,	PUNCT
gs-4426	6	8	invited	invite	VERB
gs-4426	6	9	lecturer	lecturer	NOUN
gs-4426	6	10	of	of	ADP
gs-4426	6	11	tbilisi	tbilisi	PROPN
gs-4426	6	12	state	state	PROPN
gs-4426	6	13	medical	medical	PROPN
gs-4426	6	14	university	university	PROPN
gs-4426	6	15	,	,	PUNCT
gs-4426	6	16	department	department	NOUN
gs-4426	6	17	of	of	ADP
gs-4426	6	18	molecular	molecular	ADJ
gs-4426	6	19	and	and	CCONJ
gs-4426	6	20	medical	medical	ADJ
gs-4426	6	21	genetics	genetic	NOUN
gs-4426	6	22	;	;	PUNCT
gs-4426	6	23	invited	invite	VERB
gs-4426	6	24	lecturer	lecturer	NOUN
gs-4426	6	25	of	of	ADP
gs-4426	6	26	family	family	NOUN
gs-4426	6	27	medicine	medicine	NOUN
gs-4426	6	28	of	of	ADP
gs-4426	6	29	faculty	faculty	NOUN
gs-4426	6	30	of	of	ADP
gs-4426	6	31	medicine	medicine	NOUN
gs-4426	6	32	at	at	ADP
gs-4426	6	33	georgian	georgian	PROPN
gs-4426	6	34	national	national	PROPN
gs-4426	6	35	university	university	PROPN
gs-4426	6	36	seu	seu	NOUN
gs-4426	6	37	;	;	PUNCT
gs-4426	6	38	invited	invite	VERB
gs-4426	6	39	professor	professor	NOUN
gs-4426	6	40	of	of	ADP
gs-4426	6	41	biochemistry	biochemistry	NOUN
gs-4426	6	42	and	and	CCONJ
gs-4426	6	43	molecular	molecular	ADJ
gs-4426	6	44	and	and	CCONJ
gs-4426	6	45	medical	medical	ADJ
gs-4426	6	46	genetics	genetic	NOUN
gs-4426	6	47	at	at	ADP
gs-4426	6	48	the	the	DET
gs-4426	6	49	university	university	PROPN
gs-4426	6	50	of	of	ADP
gs-4426	6	51	georgia	georgia	PROPN
gs-4426	6	52	;	;	PUNCT
gs-4426	6	53	tbilisi	tbilisi	PROPN
gs-4426	6	54	,	,	PUNCT
gs-4426	6	55	georgia	georgia	PROPN
gs-4426	6	56	;	;	PUNCT
gs-4426	6	57	9	9	NUM
gs-4426	6	58	.	.	X
gs-4426	6	59	md	md	PROPN
gs-4426	6	60	student	student	NOUN
gs-4426	6	61	of	of	ADP
gs-4426	6	62	medical	medical	ADJ
gs-4426	6	63	doctor	doctor	NOUN
gs-4426	6	64	degree	degree	NOUN
gs-4426	6	65	program	program	NOUN
gs-4426	6	66	of	of	ADP
gs-4426	6	67	faculty	faculty	NOUN
gs-4426	6	68	of	of	ADP
gs-4426	6	69	medicine	medicine	NOUN
gs-4426	6	70	at	at	ADP
gs-4426	6	71	georgian	georgian	PROPN
gs-4426	6	72	national	national	PROPN
gs-4426	6	73	university	university	PROPN
gs-4426	6	74	seu	seu	PROPN
gs-4426	6	75	;	;	PUNCT
gs-4426	6	76	tbilisi	tbilisi	PROPN
gs-4426	6	77	,	,	PUNCT
gs-4426	6	78	georgia	georgia	PROPN
gs-4426	6	79	;	;	PUNCT
gs-4426	6	80	https://orcid.org/0009-0000-4903-0145	https://orcid.org/0009-0000-4903-0145	NOUN
gs-4426	6	81	10	10	NUM
gs-4426	6	82	.	.	PUNCT
gs-4426	7	1	md	md	PROPN
gs-4426	7	2	student	student	NOUN
gs-4426	7	3	of	of	ADP
gs-4426	7	4	medical	medical	ADJ
gs-4426	7	5	doctor	doctor	NOUN
gs-4426	7	6	degree	degree	NOUN
gs-4426	7	7	program	program	NOUN
gs-4426	7	8	of	of	ADP
gs-4426	7	9	faculty	faculty	NOUN
gs-4426	7	10	of	of	ADP
gs-4426	7	11	medicine	medicine	NOUN
gs-4426	7	12	at	at	ADP
gs-4426	7	13	university	university	PROPN
gs-4426	7	14	of	of	ADP
gs-4426	7	15	georgia	georgia	PROPN
gs-4426	7	16	,	,	PUNCT
gs-4426	7	17	tbilisi	tbilisi	PROPN
gs-4426	7	18	,	,	PUNCT
gs-4426	7	19	georgia	georgia	PROPN
gs-4426	7	20	;	;	PUNCT
gs-4426	7	21	11	11	NUM
gs-4426	7	22	.	.	X
gs-4426	8	1	phd	phd	NOUN
gs-4426	8	2	,	,	PUNCT
gs-4426	8	3	doctor	doctor	NOUN
gs-4426	8	4	of	of	ADP
gs-4426	8	5	biological	biological	ADJ
gs-4426	8	6	sciences	science	NOUN
gs-4426	8	7	,	,	PUNCT
gs-4426	8	8	invited	invite	VERB
gs-4426	8	9	professor	professor	NOUN
gs-4426	8	10	of	of	ADP
gs-4426	8	11	biochemistry	biochemistry	NOUN
gs-4426	8	12	of	of	ADP
gs-4426	8	13	university	university	PROPN
gs-4426	8	14	of	of	ADP
gs-4426	8	15	georgia	georgia	PROPN
gs-4426	8	16	,	,	PUNCT
gs-4426	8	17	tbilisi	tbilisi	PROPN
gs-4426	8	18	georgia	georgia	PROPN
gs-4426	8	19	;	;	PUNCT
gs-4426	8	20	orcid	orcid	PROPN
gs-4426	8	21	:	:	PUNCT
gs-4426	8	22	https://orcid.org/0000-0001-6216-6477	https://orcid.org/0000-0001-6216-6477	NOUN
gs-4426	8	23	abstract	abstract	ADJ
gs-4426	8	24	gene	gene	NOUN
gs-4426	8	25	therapy	therapy	NOUN
gs-4426	8	26	has	have	AUX
gs-4426	8	27	emerged	emerge	VERB
gs-4426	8	28	as	as	ADP
gs-4426	8	29	one	one	NUM
gs-4426	8	30	of	of	ADP
gs-4426	8	31	the	the	DET
gs-4426	8	32	most	most	ADV
gs-4426	8	33	transformative	transformative	ADJ
gs-4426	8	34	approaches	approach	NOUN
gs-4426	8	35	in	in	ADP
gs-4426	8	36	modern	modern	ADJ
gs-4426	8	37	medicine	medicine	NOUN
gs-4426	8	38	,	,	PUNCT
gs-4426	8	39	transitioning	transition	VERB
gs-4426	8	40	from	from	ADP
gs-4426	8	41	a	a	DET
gs-4426	8	42	promising	promising	ADJ
gs-4426	8	43	experimental	experimental	ADJ
gs-4426	8	44	concept	concept	NOUN
gs-4426	8	45	to	to	ADP
gs-4426	8	46	an	an	DET
gs-4426	8	47	established	establish	VERB
gs-4426	8	48	clinical	clinical	ADJ
gs-4426	8	49	reality	reality	NOUN
gs-4426	8	50	.	.	PUNCT
gs-4426	9	1	this	this	DET
gs-4426	9	2	comprehensive	comprehensive	ADJ
gs-4426	9	3	article	article	NOUN
gs-4426	9	4	examines	examine	VERB
gs-4426	9	5	the	the	DET
gs-4426	9	6	current	current	ADJ
gs-4426	9	7	state	state	NOUN
gs-4426	9	8	of	of	ADP
gs-4426	9	9	gene	gene	NOUN
gs-4426	9	10	therapy	therapy	NOUN
gs-4426	9	11	advances	advance	VERB
gs-4426	9	12	as	as	ADP
gs-4426	9	13	of	of	ADP
gs-4426	9	14	2024	2024	NUM
gs-4426	9	15	-	-	SYM
gs-4426	9	16	2025	2025	NUM
gs-4426	9	17	,	,	PUNCT
gs-4426	9	18	focusing	focus	VERB
gs-4426	9	19	on	on	ADP
gs-4426	9	20	recent	recent	ADJ
gs-4426	9	21	regulatory	regulatory	ADJ
gs-4426	9	22	approvals	approval	NOUN
gs-4426	9	23	,	,	PUNCT
gs-4426	9	24	clinical	clinical	ADJ
gs-4426	9	25	trial	trial	NOUN
gs-4426	9	26	developments	development	NOUN
gs-4426	9	27	,	,	PUNCT
gs-4426	9	28	and	and	CCONJ
gs-4426	9	29	technological	technological	ADJ
gs-4426	9	30	innovations	innovation	NOUN
gs-4426	9	31	.	.	PUNCT
gs-4426	10	1	the	the	DET
gs-4426	10	2	past	past	ADJ
gs-4426	10	3	two	two	NUM
gs-4426	10	4	years	year	NOUN
gs-4426	10	5	have	have	AUX
gs-4426	10	6	witnessed	witness	VERB
gs-4426	10	7	unprecedented	unprecedented	ADJ
gs-4426	10	8	progress	progress	NOUN
gs-4426	10	9	,	,	PUNCT
gs-4426	10	10	including	include	VERB
gs-4426	10	11	the	the	DET
gs-4426	10	12	first	first	ADJ
gs-4426	10	13	crispr	crispr	NOUN
gs-4426	10	14	-	-	PUNCT
gs-4426	10	15	based	base	VERB
gs-4426	10	16	therapy	therapy	NOUN
gs-4426	10	17	approval	approval	NOUN
gs-4426	10	18	(	(	PUNCT
gs-4426	10	19	casgevy	casgevy	NOUN
gs-4426	10	20	)	)	PUNCT
gs-4426	10	21	,	,	PUNCT
gs-4426	10	22	expansion	expansion	NOUN
gs-4426	10	23	of	of	ADP
gs-4426	10	24	car	car	NOUN
gs-4426	10	25	-	-	PUNCT
gs-4426	10	26	t	t	NOUN
gs-4426	10	27	cell	cell	NOUN
gs-4426	10	28	therapies	therapy	NOUN
gs-4426	10	29	beyond	beyond	ADP
gs-4426	10	30	hematological	hematological	ADJ
gs-4426	10	31	malignancies	malignancy	NOUN
gs-4426	10	32	,	,	PUNCT
gs-4426	10	33	and	and	CCONJ
gs-4426	10	34	the	the	DET
gs-4426	10	35	development	development	NOUN
gs-4426	10	36	of	of	ADP
gs-4426	10	37	personalized	personalize	VERB
gs-4426	10	38	in	in	ADP
gs-4426	10	39	vivo	vivo	ADJ
gs-4426	10	40	gene	gene	NOUN
gs-4426	10	41	editing	edit	VERB
gs-4426	10	42	treatments	treatment	NOUN
gs-4426	10	43	.	.	PUNCT
gs-4426	11	1	in	in	ADP
gs-4426	11	2	2024	2024	NUM
gs-4426	11	3	alone	alone	ADV
gs-4426	11	4	,	,	PUNCT
gs-4426	11	5	seven	seven	NUM
gs-4426	11	6	novel	novel	ADJ
gs-4426	11	7	cell	cell	NOUN
gs-4426	11	8	and	and	CCONJ
gs-4426	11	9	gene	gene	NOUN
gs-4426	11	10	therapy	therapy	NOUN
gs-4426	11	11	products	product	NOUN
gs-4426	11	12	received	receive	VERB
gs-4426	11	13	fda	fda	PROPN
gs-4426	11	14	approval	approval	NOUN
gs-4426	11	15	,	,	PUNCT
gs-4426	11	16	marking	mark	VERB
gs-4426	11	17	significant	significant	ADJ
gs-4426	11	18	firsts	first	NOUN
gs-4426	11	19	in	in	ADP
gs-4426	11	20	the	the	DET
gs-4426	11	21	field	field	NOUN
gs-4426	11	22	:	:	PUNCT
gs-4426	11	23	the	the	DET
gs-4426	11	24	first	first	ADJ
gs-4426	11	25	tumorinfiltrating	tumorinfiltrate	VERB
gs-4426	11	26	lymphocyte	lymphocyte	NOUN
gs-4426	11	27	(	(	PUNCT
gs-4426	11	28	til	til	ADJ
gs-4426	11	29	)	)	PUNCT
gs-4426	11	30	therapy	therapy	NOUN
gs-4426	11	31	,	,	PUNCT
gs-4426	11	32	the	the	DET
gs-4426	11	33	first	first	ADJ
gs-4426	11	34	t	t	PROPN
gs-4426	11	35	-	-	PUNCT
gs-4426	11	36	cell	cell	NOUN
gs-4426	11	37	receptor	receptor	NOUN
gs-4426	11	38	(	(	PUNCT
gs-4426	11	39	tcr	tcr	PROPN
gs-4426	11	40	)	)	PUNCT
gs-4426	11	41	therapy	therapy	NOUN
gs-4426	11	42	,	,	PUNCT
gs-4426	11	43	and	and	CCONJ
gs-4426	11	44	the	the	DET
gs-4426	11	45	first	first	ADJ
gs-4426	11	46	georgian	georgian	NOUN
gs-4426	11	47	scientists/	scientists/	NUM
gs-4426	11	48	.	.	PUNCT
gs-4426	12	1	7	7	NUM
gs-4426	12	2	n	n	DET
gs-4426	12	3	4	4	NUM
gs-4426	12	4	,	,	PUNCT
gs-4426	12	5	2025	2025	NUM
gs-4426	12	6	594	594	NUM
gs-4426	12	7	mesenchymal	mesenchymal	ADJ
gs-4426	12	8	stem	stem	NOUN
gs-4426	12	9	cell	cell	NOUN
gs-4426	12	10	product	product	NOUN
gs-4426	12	11	in	in	ADP
gs-4426	12	12	the	the	DET
gs-4426	12	13	united	united	PROPN
gs-4426	12	14	states	states	PROPN
gs-4426	12	15	.	.	PUNCT
gs-4426	13	1	the	the	DET
gs-4426	13	2	clinical	clinical	ADJ
gs-4426	13	3	pipeline	pipeline	NOUN
gs-4426	13	4	has	have	AUX
gs-4426	13	5	expanded	expand	VERB
gs-4426	13	6	dramatically	dramatically	ADV
gs-4426	13	7	,	,	PUNCT
gs-4426	13	8	with	with	ADP
gs-4426	13	9	over	over	ADP
gs-4426	13	10	250	250	NUM
gs-4426	13	11	crispr	crispr	ADJ
gs-4426	13	12	clinical	clinical	ADJ
gs-4426	13	13	trials	trial	NOUN
gs-4426	13	14	active	active	ADJ
gs-4426	13	15	globally	globally	ADV
gs-4426	13	16	and	and	CCONJ
gs-4426	13	17	approximately	approximately	ADV
gs-4426	13	18	3,500	3,500	NUM
gs-4426	13	19	gene	gene	NOUN
gs-4426	13	20	,	,	PUNCT
gs-4426	13	21	cell	cell	NOUN
gs-4426	13	22	,	,	PUNCT
gs-4426	13	23	and	and	CCONJ
gs-4426	13	24	rna	rna	NOUN
gs-4426	13	25	therapies	therapy	NOUN
gs-4426	13	26	in	in	ADP
gs-4426	13	27	various	various	ADJ
gs-4426	13	28	stages	stage	NOUN
gs-4426	13	29	of	of	ADP
gs-4426	13	30	development	development	NOUN
gs-4426	13	31	.	.	PUNCT
gs-4426	14	1	major	major	ADJ
gs-4426	14	2	therapeutic	therapeutic	ADJ
gs-4426	14	3	advances	advance	NOUN
gs-4426	14	4	span	span	VERB
gs-4426	14	5	multiple	multiple	ADJ
gs-4426	14	6	disease	disease	NOUN
gs-4426	14	7	areas	area	NOUN
gs-4426	14	8	including	include	VERB
gs-4426	14	9	blood	blood	NOUN
gs-4426	14	10	disorders	disorder	NOUN
gs-4426	14	11	,	,	PUNCT
gs-4426	14	12	cardiovascular	cardiovascular	ADJ
gs-4426	14	13	disease	disease	NOUN
gs-4426	14	14	,	,	PUNCT
gs-4426	14	15	cancers	cancer	NOUN
gs-4426	14	16	,	,	PUNCT
gs-4426	14	17	rare	rare	ADJ
gs-4426	14	18	genetic	genetic	ADJ
gs-4426	14	19	conditions	condition	NOUN
gs-4426	14	20	,	,	PUNCT
gs-4426	14	21	diabetes	diabetes	NOUN
gs-4426	14	22	,	,	PUNCT
gs-4426	14	23	and	and	CCONJ
gs-4426	14	24	autoimmune	autoimmune	ADJ
gs-4426	14	25	disorders	disorder	NOUN
gs-4426	14	26	.	.	PUNCT
gs-4426	15	1	despite	despite	SCONJ
gs-4426	15	2	these	these	DET
gs-4426	15	3	remarkable	remarkable	ADJ
gs-4426	15	4	achievements	achievement	NOUN
gs-4426	15	5	,	,	PUNCT
gs-4426	15	6	the	the	DET
gs-4426	15	7	field	field	NOUN
gs-4426	15	8	faces	face	VERB
gs-4426	15	9	challenges	challenge	NOUN
gs-4426	15	10	including	include	VERB
gs-4426	15	11	high	high	ADJ
gs-4426	15	12	treatment	treatment	NOUN
gs-4426	15	13	costs	cost	NOUN
gs-4426	15	14	,	,	PUNCT
gs-4426	15	15	manufacturing	manufacturing	NOUN
gs-4426	15	16	complexities	complexity	NOUN
gs-4426	15	17	,	,	PUNCT
gs-4426	15	18	immunogenicity	immunogenicity	NOUN
gs-4426	15	19	concerns	concern	NOUN
gs-4426	15	20	,	,	PUNCT
gs-4426	15	21	and	and	CCONJ
gs-4426	15	22	recent	recent	ADJ
gs-4426	15	23	reductions	reduction	NOUN
gs-4426	15	24	in	in	ADP
gs-4426	15	25	venture	venture	NOUN
gs-4426	15	26	capital	capital	NOUN
gs-4426	15	27	investment	investment	NOUN
gs-4426	15	28	and	and	CCONJ
gs-4426	15	29	government	government	NOUN
gs-4426	15	30	research	research	NOUN
gs-4426	15	31	funding	funding	NOUN
gs-4426	15	32	.	.	PUNCT
gs-4426	16	1	this	this	DET
gs-4426	16	2	article	article	NOUN
gs-4426	16	3	provides	provide	VERB
gs-4426	16	4	a	a	DET
gs-4426	16	5	comprehensive	comprehensive	ADJ
gs-4426	16	6	analysis	analysis	NOUN
gs-4426	16	7	of	of	ADP
gs-4426	16	8	current	current	ADJ
gs-4426	16	9	gene	gene	NOUN
gs-4426	16	10	therapy	therapy	NOUN
gs-4426	16	11	modalities	modality	NOUN
gs-4426	16	12	,	,	PUNCT
gs-4426	16	13	clinical	clinical	ADJ
gs-4426	16	14	outcomes	outcome	NOUN
gs-4426	16	15	,	,	PUNCT
gs-4426	16	16	emerging	emerge	VERB
gs-4426	16	17	technologies	technology	NOUN
gs-4426	16	18	,	,	PUNCT
gs-4426	16	19	and	and	CCONJ
gs-4426	16	20	translational	translational	ADJ
gs-4426	16	21	challenges	challenge	NOUN
gs-4426	16	22	,	,	PUNCT
gs-4426	16	23	while	while	SCONJ
gs-4426	16	24	projecting	project	VERB
gs-4426	16	25	future	future	ADJ
gs-4426	16	26	directions	direction	NOUN
gs-4426	16	27	for	for	ADP
gs-4426	16	28	this	this	DET
gs-4426	16	29	rapidly	rapidly	ADV
gs-4426	16	30	evolving	evolve	VERB
gs-4426	16	31	therapeutic	therapeutic	ADJ
gs-4426	16	32	landscape	landscape	NOUN
gs-4426	16	33	.	.	PUNCT
gs-4426	17	1	the	the	DET
gs-4426	17	2	development	development	NOUN
gs-4426	17	3	and	and	CCONJ
gs-4426	17	4	refinement	refinement	NOUN
gs-4426	17	5	of	of	ADP
gs-4426	17	6	viral	viral	ADJ
gs-4426	17	7	vector	vector	NOUN
gs-4426	17	8	platforms	platform	NOUN
gs-4426	17	9	,	,	PUNCT
gs-4426	17	10	particularly	particularly	ADV
gs-4426	17	11	adeno	adeno	NOUN
gs-4426	17	12	-	-	PUNCT
gs-4426	17	13	associated	associate	VERB
gs-4426	17	14	virus	virus	NOUN
gs-4426	17	15	and	and	CCONJ
gs-4426	17	16	lentiviral	lentiviral	ADJ
gs-4426	17	17	systems	system	NOUN
gs-4426	17	18	,	,	PUNCT
gs-4426	17	19	have	have	AUX
gs-4426	17	20	been	be	AUX
gs-4426	17	21	central	central	ADJ
gs-4426	17	22	to	to	ADP
gs-4426	17	23	clinical	clinical	ADJ
gs-4426	17	24	success	success	NOUN
gs-4426	17	25	.	.	PUNCT
gs-4426	18	1	aav	aav	NOUN
gs-4426	18	2	vectors	vector	NOUN
gs-4426	18	3	have	have	AUX
gs-4426	18	4	demonstrated	demonstrate	VERB
gs-4426	18	5	favorable	favorable	ADJ
gs-4426	18	6	safety	safety	NOUN
gs-4426	18	7	profiles	profile	NOUN
gs-4426	18	8	,	,	PUNCT
gs-4426	18	9	tissue	tissue	NOUN
gs-4426	18	10	-	-	PUNCT
gs-4426	18	11	specific	specific	ADJ
gs-4426	18	12	tropism	tropism	NOUN
gs-4426	18	13	,	,	PUNCT
gs-4426	18	14	and	and	CCONJ
gs-4426	18	15	durable	durable	ADJ
gs-4426	18	16	transgene	transgene	NOUN
gs-4426	18	17	expression	expression	NOUN
gs-4426	18	18	in	in	ADP
gs-4426	18	19	post	post	ADJ
gs-4426	18	20	-	-	ADJ
gs-4426	18	21	mitotic	mitotic	ADJ
gs-4426	18	22	tissues	tissue	NOUN
gs-4426	18	23	,	,	PUNCT
gs-4426	18	24	enabling	enable	VERB
gs-4426	18	25	effective	effective	ADJ
gs-4426	18	26	in	in	ADP
gs-4426	18	27	vivo	vivo	ADJ
gs-4426	18	28	therapies	therapy	NOUN
gs-4426	18	29	for	for	ADP
gs-4426	18	30	conditions	condition	NOUN
gs-4426	18	31	such	such	ADJ
gs-4426	18	32	as	as	ADP
gs-4426	18	33	inherited	inherit	VERB
gs-4426	18	34	retinal	retinal	ADJ
gs-4426	18	35	dystrophies	dystrophy	NOUN
gs-4426	18	36	,	,	PUNCT
gs-4426	18	37	hemophilia	hemophilia	PROPN
gs-4426	18	38	,	,	PUNCT
gs-4426	18	39	and	and	CCONJ
gs-4426	18	40	neuromuscular	neuromuscular	ADJ
gs-4426	18	41	disorders	disorder	NOUN
gs-4426	18	42	.	.	PUNCT
gs-4426	19	1	lentiviral	lentiviral	ADJ
gs-4426	19	2	vectors	vector	NOUN
gs-4426	19	3	,	,	PUNCT
gs-4426	19	4	optimized	optimize	VERB
gs-4426	19	5	for	for	ADP
gs-4426	19	6	safety	safety	NOUN
gs-4426	19	7	and	and	CCONJ
gs-4426	19	8	stable	stable	ADJ
gs-4426	19	9	genomic	genomic	NOUN
gs-4426	19	10	integration	integration	NOUN
gs-4426	19	11	,	,	PUNCT
gs-4426	19	12	have	have	AUX
gs-4426	19	13	become	become	VERB
gs-4426	19	14	the	the	DET
gs-4426	19	15	cornerstone	cornerstone	NOUN
gs-4426	19	16	of	of	ADP
gs-4426	19	17	ex	ex	ADJ
gs-4426	19	18	vivo	vivo	NOUN
gs-4426	19	19	gene	gene	NOUN
gs-4426	19	20	therapy	therapy	NOUN
gs-4426	19	21	approaches	approach	VERB
gs-4426	19	22	,	,	PUNCT
gs-4426	19	23	supporting	support	VERB
gs-4426	19	24	long	long	ADJ
gs-4426	19	25	-	-	PUNCT
gs-4426	19	26	term	term	NOUN
gs-4426	19	27	correction	correction	NOUN
gs-4426	19	28	of	of	ADP
gs-4426	19	29	hematopoietic	hematopoietic	ADJ
gs-4426	19	30	stem	stem	NOUN
gs-4426	19	31	cells	cell	NOUN
gs-4426	19	32	and	and	CCONJ
gs-4426	19	33	immune	immune	ADJ
gs-4426	19	34	cells	cell	NOUN
gs-4426	19	35	.	.	PUNCT
gs-4426	20	1	these	these	DET
gs-4426	20	2	platforms	platform	NOUN
gs-4426	20	3	have	have	AUX
gs-4426	20	4	enabled	enable	VERB
gs-4426	20	5	curative	curative	ADJ
gs-4426	20	6	or	or	CCONJ
gs-4426	20	7	near	near	ADV
gs-4426	20	8	-	-	PUNCT
gs-4426	20	9	curative	curative	ADJ
gs-4426	20	10	outcomes	outcome	NOUN
gs-4426	20	11	in	in	ADP
gs-4426	20	12	monogenic	monogenic	ADJ
gs-4426	20	13	blood	blood	NOUN
gs-4426	20	14	disorders	disorder	NOUN
gs-4426	20	15	and	and	CCONJ
gs-4426	20	16	have	have	AUX
gs-4426	20	17	underpinned	underpin	VERB
gs-4426	20	18	the	the	DET
gs-4426	20	19	clinical	clinical	ADJ
gs-4426	20	20	success	success	NOUN
gs-4426	20	21	of	of	ADP
gs-4426	20	22	engineered	engineer	VERB
gs-4426	20	23	cell	cell	NOUN
gs-4426	20	24	therapies	therapy	NOUN
gs-4426	20	25	.	.	PUNCT
gs-4426	21	1	the	the	DET
gs-4426	21	2	advent	advent	NOUN
gs-4426	21	3	of	of	ADP
gs-4426	21	4	genome	genome	NOUN
gs-4426	21	5	editing	editing	NOUN
gs-4426	21	6	technologies	technology	NOUN
gs-4426	21	7	,	,	PUNCT
gs-4426	21	8	most	most	ADV
gs-4426	21	9	notably	notably	ADV
gs-4426	21	10	crispr	crispr	ADJ
gs-4426	21	11	-	-	PUNCT
gs-4426	21	12	cas	cas	NOUN
gs-4426	21	13	systems	system	NOUN
gs-4426	21	14	,	,	PUNCT
gs-4426	21	15	has	have	AUX
gs-4426	21	16	further	far	ADV
gs-4426	21	17	expanded	expand	VERB
gs-4426	21	18	the	the	DET
gs-4426	21	19	therapeutic	therapeutic	ADJ
gs-4426	21	20	scope	scope	NOUN
gs-4426	21	21	of	of	ADP
gs-4426	21	22	gene	gene	NOUN
gs-4426	21	23	therapy	therapy	NOUN
gs-4426	21	24	by	by	ADP
gs-4426	21	25	enabling	enable	VERB
gs-4426	21	26	precise	precise	ADJ
gs-4426	21	27	modification	modification	NOUN
gs-4426	21	28	of	of	ADP
gs-4426	21	29	endogenous	endogenous	ADJ
gs-4426	21	30	dna	dna	NOUN
gs-4426	21	31	.	.	PUNCT
gs-4426	22	1	genome	genome	NOUN
gs-4426	22	2	editing	editing	NOUN
gs-4426	22	3	allows	allow	VERB
gs-4426	22	4	direct	direct	ADJ
gs-4426	22	5	correction	correction	NOUN
gs-4426	22	6	of	of	ADP
gs-4426	22	7	pathogenic	pathogenic	ADJ
gs-4426	22	8	mutations	mutation	NOUN
gs-4426	22	9	,	,	PUNCT
gs-4426	22	10	targeted	target	VERB
gs-4426	22	11	gene	gene	NOUN
gs-4426	22	12	disruption	disruption	NOUN
gs-4426	22	13	,	,	PUNCT
gs-4426	22	14	and	and	CCONJ
gs-4426	22	15	modulation	modulation	NOUN
gs-4426	22	16	of	of	ADP
gs-4426	22	17	gene	gene	NOUN
gs-4426	22	18	expression	expression	NOUN
gs-4426	22	19	,	,	PUNCT
gs-4426	22	20	marking	mark	VERB
gs-4426	22	21	a	a	DET
gs-4426	22	22	conceptual	conceptual	ADJ
gs-4426	22	23	shift	shift	NOUN
gs-4426	22	24	from	from	ADP
gs-4426	22	25	gene	gene	NOUN
gs-4426	22	26	addition	addition	NOUN
gs-4426	22	27	toward	toward	ADP
gs-4426	22	28	permanent	permanent	ADJ
gs-4426	22	29	genetic	genetic	ADJ
gs-4426	22	30	repair	repair	NOUN
gs-4426	22	31	.	.	PUNCT
gs-4426	23	1	the	the	DET
gs-4426	23	2	clinical	clinical	ADJ
gs-4426	23	3	approval	approval	NOUN
gs-4426	23	4	of	of	ADP
gs-4426	23	5	crispr	crispr	NOUN
gs-4426	23	6	-	-	PUNCT
gs-4426	23	7	based	base	VERB
gs-4426	23	8	therapies	therapy	NOUN
gs-4426	23	9	and	and	CCONJ
gs-4426	23	10	the	the	DET
gs-4426	23	11	rapid	rapid	ADJ
gs-4426	23	12	translation	translation	NOUN
gs-4426	23	13	of	of	ADP
gs-4426	23	14	engineered	engineer	VERB
gs-4426	23	15	t	t	PROPN
gs-4426	23	16	-	-	PUNCT
gs-4426	23	17	cell	cell	NOUN
gs-4426	23	18	therapies	therapy	NOUN
gs-4426	23	19	,	,	PUNCT
gs-4426	23	20	such	such	ADJ
gs-4426	23	21	as	as	ADP
gs-4426	23	22	chimeric	chimeric	ADJ
gs-4426	23	23	antigen	antigen	ADJ
gs-4426	23	24	receptor	receptor	NOUN
gs-4426	23	25	t	t	NOUN
gs-4426	23	26	-	-	PUNCT
gs-4426	23	27	cell	cell	NOUN
gs-4426	23	28	therapy	therapy	NOUN
gs-4426	23	29	,	,	PUNCT
gs-4426	23	30	illustrate	illustrate	VERB
gs-4426	23	31	the	the	DET
gs-4426	23	32	growing	grow	VERB
gs-4426	23	33	feasibility	feasibility	NOUN
gs-4426	23	34	and	and	CCONJ
gs-4426	23	35	impact	impact	NOUN
gs-4426	23	36	of	of	ADP
gs-4426	23	37	these	these	DET
gs-4426	23	38	approaches	approach	NOUN
gs-4426	23	39	across	across	ADP
gs-4426	23	40	oncology	oncology	NOUN
gs-4426	23	41	,	,	PUNCT
gs-4426	23	42	hematology	hematology	NOUN
gs-4426	23	43	,	,	PUNCT
gs-4426	23	44	and	and	CCONJ
gs-4426	23	45	emerging	emerge	VERB
gs-4426	23	46	non	non	ADJ
gs-4426	23	47	-	-	ADJ
gs-4426	23	48	malignant	malignant	ADJ
gs-4426	23	49	indications	indication	NOUN
gs-4426	23	50	.	.	PUNCT
gs-4426	24	1	emerging	emerge	VERB
gs-4426	24	2	nextgeneration	nextgeneration	NOUN
gs-4426	24	3	tools	tool	NOUN
gs-4426	24	4	,	,	PUNCT
gs-4426	24	5	including	include	VERB
gs-4426	24	6	base	base	NOUN
gs-4426	24	7	editors	editor	NOUN
gs-4426	24	8	and	and	CCONJ
gs-4426	24	9	prime	prime	ADJ
gs-4426	24	10	editors	editor	NOUN
gs-4426	24	11	,	,	PUNCT
gs-4426	24	12	further	far	ADV
gs-4426	24	13	enhance	enhance	VERB
gs-4426	24	14	precision	precision	NOUN
gs-4426	24	15	while	while	SCONJ
gs-4426	24	16	potentially	potentially	ADV
gs-4426	24	17	reducing	reduce	VERB
gs-4426	24	18	off	off	ADP
gs-4426	24	19	-	-	PUNCT
gs-4426	24	20	target	target	NOUN
gs-4426	24	21	effects	effect	NOUN
gs-4426	24	22	and	and	CCONJ
gs-4426	24	23	genotoxic	genotoxic	ADJ
gs-4426	24	24	risk	risk	NOUN
gs-4426	24	25	.	.	PUNCT
gs-4426	25	1	keywords	keyword	NOUN
gs-4426	25	2	:	:	PUNCT
gs-4426	25	3	gene	gene	NOUN
gs-4426	25	4	therapy	therapy	NOUN
gs-4426	25	5	,	,	PUNCT
gs-4426	25	6	crispr	crispr	NOUN
gs-4426	25	7	-	-	PUNCT
gs-4426	25	8	cas9	cas9	NOUN
gs-4426	25	9	,	,	PUNCT
gs-4426	25	10	car	car	NOUN
gs-4426	25	11	-	-	PUNCT
gs-4426	25	12	t	t	NOUN
gs-4426	25	13	cell	cell	NOUN
gs-4426	25	14	therapy	therapy	NOUN
gs-4426	25	15	,	,	PUNCT
gs-4426	25	16	adeno	adeno	NOUN
gs-4426	25	17	-	-	PUNCT
gs-4426	25	18	associated	associate	VERB
gs-4426	25	19	virus	virus	NOUN
gs-4426	25	20	(	(	PUNCT
gs-4426	25	21	aav	aav	PROPN
gs-4426	25	22	)	)	PUNCT
gs-4426	25	23	,	,	PUNCT
gs-4426	25	24	gene	gene	NOUN
gs-4426	25	25	editing	editing	NOUN
gs-4426	25	26	,	,	PUNCT
gs-4426	25	27	cell	cell	NOUN
gs-4426	25	28	therapy	therapy	NOUN
gs-4426	25	29	,	,	PUNCT
gs-4426	25	30	clinical	clinical	ADJ
gs-4426	25	31	trials	trial	NOUN
gs-4426	25	32	,	,	PUNCT
gs-4426	25	33	personalized	personalized	ADJ
gs-4426	25	34	medicine	medicine	NOUN
gs-4426	25	35	,	,	PUNCT
gs-4426	25	36	rare	rare	ADJ
gs-4426	25	37	diseases	disease	NOUN
gs-4426	25	38	,	,	PUNCT
gs-4426	25	39	regenerative	regenerative	ADJ
gs-4426	25	40	medicine	medicine	NOUN
gs-4426	25	41	introduction	introduction	NOUN
gs-4426	25	42	gene	gene	NOUN
gs-4426	25	43	therapy	therapy	NOUN
gs-4426	25	44	represents	represent	VERB
gs-4426	25	45	a	a	DET
gs-4426	25	46	transformative	transformative	ADJ
gs-4426	25	47	paradigm	paradigm	NOUN
gs-4426	25	48	shift	shift	NOUN
gs-4426	25	49	in	in	ADP
gs-4426	25	50	medicine	medicine	NOUN
gs-4426	25	51	,	,	PUNCT
gs-4426	25	52	offering	offer	VERB
gs-4426	25	53	the	the	DET
gs-4426	25	54	potential	potential	NOUN
gs-4426	25	55	to	to	PART
gs-4426	25	56	address	address	VERB
gs-4426	25	57	diseases	disease	NOUN
gs-4426	25	58	at	at	ADP
gs-4426	25	59	their	their	PRON
gs-4426	25	60	molecular	molecular	ADJ
gs-4426	25	61	origins	origin	NOUN
gs-4426	25	62	rather	rather	ADV
gs-4426	25	63	than	than	ADP
gs-4426	25	64	merely	merely	ADV
gs-4426	25	65	ameliorating	ameliorate	VERB
gs-4426	25	66	symptoms	symptom	NOUN
gs-4426	25	67	.	.	PUNCT
gs-4426	26	1	the	the	DET
gs-4426	26	2	fundamental	fundamental	ADJ
gs-4426	26	3	therapeutic	therapeutic	ADJ
gs-4426	26	4	principle	principle	NOUN
gs-4426	26	5	involves	involve	VERB
gs-4426	26	6	the	the	DET
gs-4426	26	7	deliberate	deliberate	ADJ
gs-4426	26	8	introduction	introduction	NOUN
gs-4426	26	9	,	,	PUNCT
gs-4426	26	10	deletion	deletion	NOUN
gs-4426	26	11	,	,	PUNCT
gs-4426	26	12	or	or	CCONJ
gs-4426	26	13	modification	modification	NOUN
gs-4426	26	14	of	of	ADP
gs-4426	26	15	genetic	genetic	ADJ
gs-4426	26	16	material	material	NOUN
gs-4426	26	17	within	within	ADP
gs-4426	26	18	a	a	DET
gs-4426	26	19	patient	patient	NOUN
gs-4426	26	20	's	's	PART
gs-4426	26	21	cells	cell	NOUN
gs-4426	26	22	to	to	PART
gs-4426	26	23	treat	treat	VERB
gs-4426	26	24	or	or	CCONJ
gs-4426	26	25	prevent	prevent	VERB
gs-4426	26	26	disease	disease	NOUN
gs-4426	26	27	.	.	PUNCT
gs-4426	27	1	after	after	ADP
gs-4426	27	2	more	more	ADJ
gs-4426	27	3	than	than	ADP
gs-4426	27	4	four	four	NUM
gs-4426	27	5	decades	decade	NOUN
gs-4426	27	6	of	of	ADP
gs-4426	27	7	development	development	NOUN
gs-4426	27	8	marked	mark	VERB
gs-4426	27	9	by	by	ADP
gs-4426	27	10	early	early	ADJ
gs-4426	27	11	promise	promise	NOUN
gs-4426	27	12	,	,	PUNCT
gs-4426	27	13	significant	significant	ADJ
gs-4426	27	14	setbacks	setback	NOUN
gs-4426	27	15	,	,	PUNCT
gs-4426	27	16	and	and	CCONJ
gs-4426	27	17	continuous	continuous	ADJ
gs-4426	27	18	refinement	refinement	NOUN
gs-4426	27	19	,	,	PUNCT
gs-4426	27	20	gene	gene	NOUN
gs-4426	27	21	therapy	therapy	NOUN
gs-4426	27	22	has	have	AUX
gs-4426	27	23	emerged	emerge	VERB
gs-4426	27	24	as	as	ADP
gs-4426	27	25	an	an	DET
gs-4426	27	26	established	establish	VERB
gs-4426	27	27	clinical	clinical	ADJ
gs-4426	27	28	modality	modality	NOUN
gs-4426	27	29	characterized	characterize	VERB
gs-4426	27	30	by	by	ADP
gs-4426	27	31	regulatory	regulatory	ADJ
gs-4426	27	32	approvals	approval	NOUN
gs-4426	27	33	,	,	PUNCT
gs-4426	27	34	demonstrable	demonstrable	ADJ
gs-4426	27	35	clinical	clinical	ADJ
gs-4426	27	36	efficacy	efficacy	NOUN
gs-4426	27	37	,	,	PUNCT
gs-4426	27	38	and	and	CCONJ
gs-4426	27	39	expanding	expand	VERB
gs-4426	27	40	therapeutic	therapeutic	ADJ
gs-4426	27	41	applications	application	NOUN
gs-4426	27	42	across	across	ADP
gs-4426	27	43	diverse	diverse	ADJ
gs-4426	27	44	disease	disease	NOUN
gs-4426	27	45	categories	category	NOUN
gs-4426	27	46	.	.	PUNCT
gs-4426	28	1	the	the	DET
gs-4426	28	2	conceptual	conceptual	ADJ
gs-4426	28	3	and	and	CCONJ
gs-4426	28	4	technical	technical	ADJ
gs-4426	28	5	foundations	foundation	NOUN
gs-4426	28	6	of	of	ADP
gs-4426	28	7	gene	gene	NOUN
gs-4426	28	8	therapy	therapy	NOUN
gs-4426	28	9	span	span	NOUN
gs-4426	28	10	over	over	ADP
gs-4426	28	11	forty	forty	NUM
gs-4426	28	12	years	year	NOUN
gs-4426	28	13	of	of	ADP
gs-4426	28	14	scientific	scientific	ADJ
gs-4426	28	15	investigation	investigation	NOUN
gs-4426	28	16	.	.	PUNCT
gs-4426	29	1	the	the	DET
gs-4426	29	2	first	first	ADJ
gs-4426	29	3	human	human	ADJ
gs-4426	29	4	gene	gene	NOUN
gs-4426	29	5	therapy	therapy	NOUN
gs-4426	29	6	clinical	clinical	ADJ
gs-4426	29	7	trial	trial	NOUN
gs-4426	29	8	was	be	AUX
gs-4426	29	9	conducted	conduct	VERB
gs-4426	29	10	in	in	ADP
gs-4426	29	11	1990	1990	NUM
gs-4426	29	12	,	,	PUNCT
gs-4426	29	13	initiating	initiate	VERB
gs-4426	29	14	an	an	DET
gs-4426	29	15	era	era	NOUN
gs-4426	29	16	of	of	ADP
gs-4426	29	17	cautious	cautious	ADJ
gs-4426	29	18	optimism	optimism	NOUN
gs-4426	29	19	that	that	PRON
gs-4426	29	20	was	be	AUX
gs-4426	29	21	subsequently	subsequently	ADV
gs-4426	29	22	tempered	temper	VERB
gs-4426	29	23	by	by	ADP
gs-4426	29	24	safety	safety	NOUN
gs-4426	29	25	concerns	concern	NOUN
gs-4426	29	26	and	and	CCONJ
gs-4426	29	27	limited	limited	ADJ
gs-4426	29	28	therapeutic	therapeutic	ADJ
gs-4426	29	29	efficacy	efficacy	NOUN
gs-4426	29	30	in	in	ADP
gs-4426	29	31	early	early	ADJ
gs-4426	29	32	studies	study	NOUN
gs-4426	29	33	.	.	PUNCT
gs-4426	30	1	the	the	DET
gs-4426	30	2	field	field	NOUN
gs-4426	30	3	experienced	experience	VERB
gs-4426	30	4	a	a	DET
gs-4426	30	5	renaissance	renaissance	NOUN
gs-4426	30	6	beginning	begin	VERB
gs-4426	30	7	in	in	ADP
gs-4426	30	8	the	the	DET
gs-4426	30	9	2010s	2010s	NUM
gs-4426	30	10	,	,	PUNCT
gs-4426	30	11	driven	drive	VERB
gs-4426	30	12	georgian	georgian	NOUN
gs-4426	30	13	scientists/	scientists/	NUM
gs-4426	30	14	.	.	PUNCT
gs-4426	31	1	7	7	NUM
gs-4426	31	2	n	n	DET
gs-4426	31	3	4	4	NUM
gs-4426	31	4	,	,	PUNCT
gs-4426	31	5	2025	2025	NUM
gs-4426	31	6	595	595	NUM
gs-4426	31	7	primarily	primarily	ADV
gs-4426	31	8	by	by	ADP
gs-4426	31	9	technological	technological	ADJ
gs-4426	31	10	innovations	innovation	NOUN
gs-4426	31	11	in	in	ADP
gs-4426	31	12	viral	viral	ADJ
gs-4426	31	13	vector	vector	NOUN
gs-4426	31	14	engineering	engineering	NOUN
gs-4426	31	15	,	,	PUNCT
gs-4426	31	16	particularly	particularly	ADV
gs-4426	31	17	adeno	adeno	NOUN
gs-4426	31	18	-	-	PUNCT
gs-4426	31	19	associated	associate	VERB
gs-4426	31	20	virus	virus	NOUN
gs-4426	31	21	(	(	PUNCT
gs-4426	31	22	aav	aav	NOUN
gs-4426	31	23	)	)	PUNCT
gs-4426	31	24	vectors	vector	NOUN
gs-4426	31	25	,	,	PUNCT
gs-4426	31	26	and	and	CCONJ
gs-4426	31	27	the	the	DET
gs-4426	31	28	revolutionary	revolutionary	ADJ
gs-4426	31	29	development	development	NOUN
gs-4426	31	30	of	of	ADP
gs-4426	31	31	crispr	crispr	ADJ
gs-4426	31	32	-	-	PUNCT
gs-4426	31	33	cas9	cas9	NOUN
gs-4426	31	34	gene	gene	NOUN
gs-4426	31	35	editing	edit	VERB
gs-4426	31	36	technology	technology	NOUN
gs-4426	31	37	in	in	ADP
gs-4426	31	38	2012	2012	NUM
gs-4426	31	39	.	.	PUNCT
gs-4426	32	1	the	the	DET
gs-4426	32	2	year	year	NOUN
gs-4426	32	3	2017	2017	NUM
gs-4426	32	4	marked	mark	VERB
gs-4426	32	5	a	a	DET
gs-4426	32	6	watershed	watershed	ADJ
gs-4426	32	7	moment	moment	NOUN
gs-4426	32	8	with	with	ADP
gs-4426	32	9	the	the	DET
gs-4426	32	10	first	first	ADJ
gs-4426	32	11	gene	gene	NOUN
gs-4426	32	12	therapy	therapy	NOUN
gs-4426	32	13	approvals	approval	NOUN
gs-4426	32	14	by	by	ADP
gs-4426	32	15	the	the	DET
gs-4426	32	16	united	united	PROPN
gs-4426	32	17	states	states	PROPN
gs-4426	32	18	food	food	PROPN
gs-4426	32	19	and	and	CCONJ
gs-4426	32	20	drug	drug	PROPN
gs-4426	32	21	administration	administration	NOUN
gs-4426	32	22	(	(	PUNCT
gs-4426	32	23	fda	fda	PROPN
gs-4426	32	24	)	)	PUNCT
gs-4426	32	25	,	,	PUNCT
gs-4426	32	26	and	and	CCONJ
gs-4426	32	27	momentum	momentum	NOUN
gs-4426	32	28	has	have	AUX
gs-4426	32	29	accelerated	accelerate	VERB
gs-4426	32	30	dramatically	dramatically	ADV
gs-4426	32	31	in	in	ADP
gs-4426	32	32	subsequent	subsequent	ADJ
gs-4426	32	33	years	year	NOUN
gs-4426	32	34	.	.	PUNCT
gs-4426	33	1	the	the	DET
gs-4426	33	2	contemporary	contemporary	ADJ
gs-4426	33	3	gene	gene	NOUN
gs-4426	33	4	therapy	therapy	NOUN
gs-4426	33	5	landscape	landscape	NOUN
gs-4426	33	6	encompasses	encompass	VERB
gs-4426	33	7	over	over	ADP
gs-4426	33	8	3,500	3,500	NUM
gs-4426	33	9	therapies	therapy	NOUN
gs-4426	33	10	spanning	span	VERB
gs-4426	33	11	preclinical	preclinical	ADJ
gs-4426	33	12	through	through	ADP
gs-4426	33	13	clinical	clinical	ADJ
gs-4426	33	14	development	development	NOUN
gs-4426	33	15	stages	stage	NOUN
gs-4426	33	16	worldwide	worldwide	ADV
gs-4426	33	17	,	,	PUNCT
gs-4426	33	18	including	include	VERB
gs-4426	33	19	approximately	approximately	ADV
gs-4426	33	20	250	250	NUM
gs-4426	33	21	crispr	crispr	ADJ
gs-4426	33	22	-	-	PUNCT
gs-4426	33	23	specific	specific	ADJ
gs-4426	33	24	clinical	clinical	ADJ
gs-4426	33	25	trials	trial	NOUN
gs-4426	33	26	actively	actively	ADV
gs-4426	33	27	recruiting	recruit	VERB
gs-4426	33	28	patients	patient	NOUN
gs-4426	33	29	globally	globally	ADV
gs-4426	33	30	.	.	PUNCT
gs-4426	34	1	the	the	DET
gs-4426	34	2	field	field	NOUN
gs-4426	34	3	has	have	AUX
gs-4426	34	4	diversified	diversify	VERB
gs-4426	34	5	substantially	substantially	ADV
gs-4426	34	6	beyond	beyond	ADP
gs-4426	34	7	rare	rare	ADJ
gs-4426	34	8	monogenic	monogenic	ADJ
gs-4426	34	9	disorders	disorder	NOUN
gs-4426	34	10	to	to	PART
gs-4426	34	11	address	address	VERB
gs-4426	34	12	common	common	ADJ
gs-4426	34	13	diseases	disease	NOUN
gs-4426	34	14	with	with	ADP
gs-4426	34	15	significant	significant	ADJ
gs-4426	34	16	public	public	ADJ
gs-4426	34	17	health	health	NOUN
gs-4426	34	18	impact	impact	NOUN
gs-4426	34	19	,	,	PUNCT
gs-4426	34	20	including	include	VERB
gs-4426	34	21	cardiovascular	cardiovascular	ADJ
gs-4426	34	22	disease	disease	NOUN
gs-4426	34	23	,	,	PUNCT
gs-4426	34	24	diabetes	diabetes	NOUN
gs-4426	34	25	,	,	PUNCT
gs-4426	34	26	autoimmune	autoimmune	ADJ
gs-4426	34	27	conditions	condition	NOUN
gs-4426	34	28	,	,	PUNCT
gs-4426	34	29	and	and	CCONJ
gs-4426	34	30	various	various	ADJ
gs-4426	34	31	malignancies	malignancy	NOUN
gs-4426	34	32	.	.	PUNCT
gs-4426	35	1	chimeric	chimeric	ADJ
gs-4426	35	2	antigen	antigen	ADJ
gs-4426	35	3	receptor	receptor	NOUN
gs-4426	35	4	t	t	NOUN
gs-4426	35	5	-	-	PUNCT
gs-4426	35	6	cell	cell	NOUN
gs-4426	35	7	(	(	PUNCT
gs-4426	35	8	car	car	NOUN
gs-4426	35	9	-	-	PUNCT
gs-4426	35	10	t	t	PROPN
gs-4426	35	11	)	)	PUNCT
gs-4426	35	12	therapy	therapy	NOUN
gs-4426	35	13	has	have	AUX
gs-4426	35	14	achieved	achieve	VERB
gs-4426	35	15	remarkable	remarkable	ADJ
gs-4426	35	16	clinical	clinical	ADJ
gs-4426	35	17	success	success	NOUN
gs-4426	35	18	in	in	ADP
gs-4426	35	19	hematological	hematological	ADJ
gs-4426	35	20	malignancies	malignancy	NOUN
gs-4426	35	21	,	,	PUNCT
gs-4426	35	22	with	with	ADP
gs-4426	35	23	seven	seven	NUM
gs-4426	35	24	fda	fda	PROPN
gs-4426	35	25	-	-	PUNCT
gs-4426	35	26	approved	approve	VERB
gs-4426	35	27	products	product	NOUN
gs-4426	35	28	demonstrating	demonstrate	VERB
gs-4426	35	29	the	the	DET
gs-4426	35	30	clinical	clinical	ADJ
gs-4426	35	31	potential	potential	NOUN
gs-4426	35	32	of	of	ADP
gs-4426	35	33	genetically	genetically	ADV
gs-4426	35	34	engineered	engineer	VERB
gs-4426	35	35	cell	cell	NOUN
gs-4426	35	36	therapies	therapy	NOUN
gs-4426	35	37	.	.	PUNCT
gs-4426	36	1	the	the	DET
gs-4426	36	2	historic	historic	ADJ
gs-4426	36	3	approval	approval	NOUN
gs-4426	36	4	of	of	ADP
gs-4426	36	5	casgevy	casgevy	NOUN
gs-4426	36	6	(	(	PUNCT
gs-4426	36	7	exagamglogene	exagamglogene	NOUN
gs-4426	36	8	autotemcel	autotemcel	PROPN
gs-4426	36	9	)	)	PUNCT
gs-4426	36	10	in	in	ADP
gs-4426	36	11	december	december	PROPN
gs-4426	36	12	2023	2023	NUM
gs-4426	36	13	represented	represent	VERB
gs-4426	36	14	the	the	DET
gs-4426	36	15	first	first	ADJ
gs-4426	36	16	crispr	crispr	NOUN
gs-4426	36	17	-	-	PUNCT
gs-4426	36	18	based	base	VERB
gs-4426	36	19	medicine	medicine	NOUN
gs-4426	36	20	authorized	authorize	VERB
gs-4426	36	21	for	for	ADP
gs-4426	36	22	clinical	clinical	ADJ
gs-4426	36	23	use	use	NOUN
gs-4426	36	24	,	,	PUNCT
gs-4426	36	25	treating	treat	VERB
gs-4426	36	26	sickle	sickle	NOUN
gs-4426	36	27	cell	cell	NOUN
gs-4426	36	28	disease	disease	NOUN
gs-4426	36	29	and	and	CCONJ
gs-4426	36	30	transfusion	transfusion	NOUN
gs-4426	36	31	-	-	PUNCT
gs-4426	36	32	dependent	dependent	ADJ
gs-4426	36	33	beta	beta	NOUN
gs-4426	36	34	thalassemia	thalassemia	NOUN
gs-4426	36	35	through	through	ADP
gs-4426	36	36	ex	ex	PRON
gs-4426	36	37	vivo	vivo	NOUN
gs-4426	36	38	editing	editing	NOUN
gs-4426	36	39	of	of	ADP
gs-4426	36	40	hematopoietic	hematopoietic	ADJ
gs-4426	36	41	stem	stem	NOUN
gs-4426	36	42	cells	cell	NOUN
gs-4426	36	43	.	.	PUNCT
gs-4426	37	1	recent	recent	ADJ
gs-4426	37	2	regulatory	regulatory	ADJ
gs-4426	37	3	approvals	approval	NOUN
gs-4426	37	4	have	have	AUX
gs-4426	37	5	established	establish	VERB
gs-4426	37	6	gene	gene	NOUN
gs-4426	37	7	therapy	therapy	NOUN
gs-4426	37	8	as	as	ADP
gs-4426	37	9	a	a	DET
gs-4426	37	10	viable	viable	ADJ
gs-4426	37	11	treatment	treatment	NOUN
gs-4426	37	12	option	option	NOUN
gs-4426	37	13	for	for	ADP
gs-4426	37	14	previously	previously	ADV
gs-4426	37	15	intractable	intractable	ADJ
gs-4426	37	16	conditions	condition	NOUN
gs-4426	37	17	.	.	PUNCT
gs-4426	38	1	the	the	DET
gs-4426	38	2	simultaneous	simultaneous	ADJ
gs-4426	38	3	fda	fda	PROPN
gs-4426	38	4	approval	approval	NOUN
gs-4426	38	5	of	of	ADP
gs-4426	38	6	two	two	NUM
gs-4426	38	7	gene	gene	NOUN
gs-4426	38	8	therapy	therapy	NOUN
gs-4426	38	9	products	product	NOUN
gs-4426	38	10	for	for	ADP
gs-4426	38	11	sickle	sickle	NOUN
gs-4426	38	12	cell	cell	NOUN
gs-4426	38	13	disease	disease	NOUN
gs-4426	38	14	in	in	ADP
gs-4426	38	15	late	late	ADJ
gs-4426	38	16	2023	2023	NUM
gs-4426	38	17	—	—	PUNCT
gs-4426	38	18	the	the	DET
gs-4426	38	19	crispr	crispr	NOUN
gs-4426	38	20	-	-	PUNCT
gs-4426	38	21	based	base	VERB
gs-4426	38	22	casgevy	casgevy	NOUN
gs-4426	38	23	and	and	CCONJ
gs-4426	38	24	the	the	DET
gs-4426	38	25	lentiviral	lentiviral	ADJ
gs-4426	38	26	vector	vector	NOUN
gs-4426	38	27	-	-	PUNCT
gs-4426	38	28	based	base	VERB
gs-4426	38	29	lyfgenia	lyfgenia	NOUN
gs-4426	38	30	—	—	PUNCT
gs-4426	38	31	marked	mark	VERB
gs-4426	38	32	a	a	DET
gs-4426	38	33	dual	dual	ADJ
gs-4426	38	34	breakthrough	breakthrough	NOUN
gs-4426	38	35	demonstrating	demonstrate	VERB
gs-4426	38	36	the	the	DET
gs-4426	38	37	clinical	clinical	ADJ
gs-4426	38	38	maturation	maturation	NOUN
gs-4426	38	39	of	of	ADP
gs-4426	38	40	multiple	multiple	ADJ
gs-4426	38	41	gene	gene	NOUN
gs-4426	38	42	therapy	therapy	NOUN
gs-4426	38	43	platforms	platform	NOUN
gs-4426	38	44	.	.	PUNCT
gs-4426	39	1	these	these	DET
gs-4426	39	2	approvals	approval	NOUN
gs-4426	39	3	validated	validate	VERB
gs-4426	39	4	decades	decade	NOUN
gs-4426	39	5	of	of	ADP
gs-4426	39	6	translational	translational	ADJ
gs-4426	39	7	research	research	NOUN
gs-4426	39	8	and	and	CCONJ
gs-4426	39	9	established	establish	VERB
gs-4426	39	10	precedents	precedent	NOUN
gs-4426	39	11	for	for	ADP
gs-4426	39	12	addressing	address	VERB
gs-4426	39	13	monogenic	monogenic	ADJ
gs-4426	39	14	blood	blood	NOUN
gs-4426	39	15	disorders	disorder	NOUN
gs-4426	39	16	through	through	ADP
gs-4426	39	17	genetic	genetic	ADJ
gs-4426	39	18	modification	modification	NOUN
gs-4426	39	19	of	of	ADP
gs-4426	39	20	hematopoietic	hematopoietic	ADJ
gs-4426	39	21	stem	stem	NOUN
gs-4426	39	22	cells	cell	NOUN
gs-4426	39	23	.	.	PUNCT
gs-4426	40	1	historical	historical	ADJ
gs-4426	40	2	evolution	evolution	NOUN
gs-4426	40	3	of	of	ADP
gs-4426	40	4	gene	gene	NOUN
gs-4426	40	5	therapy	therapy	NOUN
gs-4426	40	6	the	the	DET
gs-4426	40	7	evolution	evolution	NOUN
gs-4426	40	8	of	of	ADP
gs-4426	40	9	gene	gene	NOUN
gs-4426	40	10	therapy	therapy	NOUN
gs-4426	40	11	as	as	ADP
gs-4426	40	12	a	a	DET
gs-4426	40	13	therapeutic	therapeutic	ADJ
gs-4426	40	14	modality	modality	NOUN
gs-4426	40	15	reflects	reflect	VERB
gs-4426	40	16	decades	decade	NOUN
gs-4426	40	17	of	of	ADP
gs-4426	40	18	scientific	scientific	ADJ
gs-4426	40	19	innovation	innovation	NOUN
gs-4426	40	20	,	,	PUNCT
gs-4426	40	21	regulatory	regulatory	ADJ
gs-4426	40	22	adaptation	adaptation	NOUN
gs-4426	40	23	,	,	PUNCT
gs-4426	40	24	and	and	CCONJ
gs-4426	40	25	clinical	clinical	ADJ
gs-4426	40	26	learning	learning	NOUN
gs-4426	40	27	.	.	PUNCT
gs-4426	41	1	the	the	DET
gs-4426	41	2	conceptual	conceptual	ADJ
gs-4426	41	3	framework	framework	NOUN
gs-4426	41	4	for	for	ADP
gs-4426	41	5	gene	gene	NOUN
gs-4426	41	6	therapy	therapy	NOUN
gs-4426	41	7	emerged	emerge	VERB
gs-4426	41	8	in	in	ADP
gs-4426	41	9	the	the	DET
gs-4426	41	10	1960s	1960	NOUN
gs-4426	41	11	and	and	CCONJ
gs-4426	41	12	1970s	1970	NOUN
gs-4426	41	13	as	as	SCONJ
gs-4426	41	14	molecular	molecular	ADJ
gs-4426	41	15	biologists	biologist	NOUN
gs-4426	41	16	began	begin	VERB
gs-4426	41	17	to	to	PART
gs-4426	41	18	understand	understand	VERB
gs-4426	41	19	the	the	DET
gs-4426	41	20	genetic	genetic	ADJ
gs-4426	41	21	basis	basis	NOUN
gs-4426	41	22	of	of	ADP
gs-4426	41	23	human	human	ADJ
gs-4426	41	24	disease	disease	NOUN
gs-4426	41	25	and	and	CCONJ
gs-4426	41	26	developed	developed	ADJ
gs-4426	41	27	tools	tool	NOUN
gs-4426	41	28	for	for	ADP
gs-4426	41	29	manipulating	manipulate	VERB
gs-4426	41	30	dna	dna	PROPN
gs-4426	41	31	(	(	PUNCT
gs-4426	41	32	wirth	wirth	PROPN
gs-4426	41	33	et	et	PROPN
gs-4426	41	34	al	al	PROPN
gs-4426	41	35	.	.	PROPN
gs-4426	41	36	,	,	PUNCT
gs-4426	41	37	2013	2013	NUM
gs-4426	41	38	)	)	PUNCT
gs-4426	41	39	.	.	PUNCT
gs-4426	42	1	early	early	ADJ
gs-4426	42	2	experiments	experiment	NOUN
gs-4426	42	3	focused	focus	VERB
gs-4426	42	4	on	on	ADP
gs-4426	42	5	bacterial	bacterial	ADJ
gs-4426	42	6	and	and	CCONJ
gs-4426	42	7	viral	viral	ADJ
gs-4426	42	8	systems	system	NOUN
gs-4426	42	9	,	,	PUNCT
gs-4426	42	10	establishing	establish	VERB
gs-4426	42	11	foundational	foundational	ADJ
gs-4426	42	12	knowledge	knowledge	NOUN
gs-4426	42	13	about	about	ADP
gs-4426	42	14	gene	gene	NOUN
gs-4426	42	15	transfer	transfer	NOUN
gs-4426	42	16	mechanisms	mechanism	NOUN
gs-4426	42	17	and	and	CCONJ
gs-4426	42	18	expression	expression	NOUN
gs-4426	42	19	regulation	regulation	NOUN
gs-4426	42	20	.	.	PUNCT
gs-4426	43	1	the	the	DET
gs-4426	43	2	identification	identification	NOUN
gs-4426	43	3	of	of	ADP
gs-4426	43	4	restriction	restriction	NOUN
gs-4426	43	5	endonucleases	endonuclease	NOUN
gs-4426	43	6	,	,	PUNCT
gs-4426	43	7	the	the	DET
gs-4426	43	8	development	development	NOUN
gs-4426	43	9	of	of	ADP
gs-4426	43	10	recombinant	recombinant	ADJ
gs-4426	43	11	dna	dna	NOUN
gs-4426	43	12	technology	technology	NOUN
gs-4426	43	13	,	,	PUNCT
gs-4426	43	14	and	and	CCONJ
gs-4426	43	15	the	the	DET
gs-4426	43	16	characterization	characterization	NOUN
gs-4426	43	17	of	of	ADP
gs-4426	43	18	viral	viral	ADJ
gs-4426	43	19	vectors	vector	NOUN
gs-4426	43	20	capable	capable	ADJ
gs-4426	43	21	of	of	ADP
gs-4426	43	22	transducing	transduce	VERB
gs-4426	43	23	mammalian	mammalian	ADJ
gs-4426	43	24	cells	cell	NOUN
gs-4426	43	25	provided	provide	VERB
gs-4426	43	26	the	the	DET
gs-4426	43	27	technical	technical	ADJ
gs-4426	43	28	foundation	foundation	NOUN
gs-4426	43	29	for	for	ADP
gs-4426	43	30	therapeutic	therapeutic	ADJ
gs-4426	43	31	applications	application	NOUN
gs-4426	43	32	.	.	PUNCT
gs-4426	44	1	these	these	DET
gs-4426	44	2	pioneering	pioneer	VERB
gs-4426	44	3	molecular	molecular	ADJ
gs-4426	44	4	biology	biology	NOUN
gs-4426	44	5	advances	advance	NOUN
gs-4426	44	6	created	create	VERB
gs-4426	44	7	the	the	DET
gs-4426	44	8	possibility	possibility	NOUN
gs-4426	44	9	of	of	ADP
gs-4426	44	10	correcting	correct	VERB
gs-4426	44	11	genetic	genetic	ADJ
gs-4426	44	12	defects	defect	NOUN
gs-4426	44	13	at	at	ADP
gs-4426	44	14	their	their	PRON
gs-4426	44	15	source	source	NOUN
gs-4426	44	16	rather	rather	ADV
gs-4426	44	17	than	than	ADP
gs-4426	44	18	treating	treat	VERB
gs-4426	44	19	downstream	downstream	ADJ
gs-4426	44	20	consequences	consequence	NOUN
gs-4426	44	21	.	.	PUNCT
gs-4426	45	1	the	the	DET
gs-4426	45	2	approved	approve	VERB
gs-4426	45	3	human	human	ADJ
gs-4426	45	4	gene	gene	NOUN
gs-4426	45	5	therapy	therapy	NOUN
gs-4426	45	6	protocol	protocol	NOUN
gs-4426	45	7	,	,	PUNCT
gs-4426	45	8	initiated	initiate	VERB
gs-4426	45	9	in	in	ADP
gs-4426	45	10	1990	1990	NUM
gs-4426	45	11	,	,	PUNCT
gs-4426	45	12	and	and	CCONJ
gs-4426	45	13	targeted	target	VERB
gs-4426	45	14	adenosine	adenosine	NOUN
gs-4426	45	15	deaminasesevere	deaminasesevere	NOUN
gs-4426	45	16	combined	combine	VERB
gs-4426	45	17	immunodeficiency	immunodeficiency	NOUN
gs-4426	45	18	(	(	PUNCT
gs-4426	45	19	ada	ada	NOUN
gs-4426	45	20	-	-	PUNCT
gs-4426	45	21	scid	scid	PROPN
gs-4426	45	22	)	)	PUNCT
gs-4426	45	23	,	,	PUNCT
gs-4426	45	24	a	a	DET
gs-4426	45	25	rare	rare	ADJ
gs-4426	45	26	monogenic	monogenic	ADJ
gs-4426	45	27	disorder	disorder	NOUN
gs-4426	45	28	causing	cause	VERB
gs-4426	45	29	profound	profound	ADJ
gs-4426	45	30	immune	immune	ADJ
gs-4426	45	31	dysfunction	dysfunction	NOUN
gs-4426	45	32	.	.	PUNCT
gs-4426	46	1	this	this	DET
gs-4426	46	2	landmark	landmark	NOUN
gs-4426	46	3	trial	trial	NOUN
gs-4426	46	4	employed	employ	VERB
gs-4426	46	5	ex	ex	PRON
gs-4426	46	6	vivo	vivo	ADJ
gs-4426	46	7	transduction	transduction	NOUN
gs-4426	46	8	of	of	ADP
gs-4426	46	9	autologous	autologous	ADJ
gs-4426	46	10	t	t	NOUN
gs-4426	46	11	lymphocytes	lymphocyte	NOUN
gs-4426	46	12	with	with	ADP
gs-4426	46	13	a	a	DET
gs-4426	46	14	retroviral	retroviral	ADJ
gs-4426	46	15	vector	vector	NOUN
gs-4426	46	16	carrying	carry	VERB
gs-4426	46	17	the	the	DET
gs-4426	46	18	ada	ada	PROPN
gs-4426	46	19	gene	gene	NOUN
gs-4426	46	20	.	.	PUNCT
gs-4426	47	1	while	while	SCONJ
gs-4426	47	2	the	the	DET
gs-4426	47	3	clinical	clinical	ADJ
gs-4426	47	4	benefits	benefit	NOUN
gs-4426	47	5	were	be	AUX
gs-4426	47	6	modest	modest	ADJ
gs-4426	47	7	and	and	CCONJ
gs-4426	47	8	patients	patient	NOUN
gs-4426	47	9	continued	continue	VERB
gs-4426	47	10	to	to	PART
gs-4426	47	11	require	require	VERB
gs-4426	47	12	enzyme	enzyme	NOUN
gs-4426	47	13	replacement	replacement	NOUN
gs-4426	47	14	therapy	therapy	NOUN
gs-4426	47	15	,	,	PUNCT
gs-4426	47	16	the	the	DET
gs-4426	47	17	trial	trial	NOUN
gs-4426	47	18	demonstrated	demonstrate	VERB
gs-4426	47	19	the	the	DET
gs-4426	47	20	feasibility	feasibility	NOUN
gs-4426	47	21	and	and	CCONJ
gs-4426	47	22	safety	safety	NOUN
gs-4426	47	23	of	of	ADP
gs-4426	47	24	gene	gene	NOUN
gs-4426	47	25	transfer	transfer	NOUN
gs-4426	47	26	in	in	ADP
gs-4426	47	27	humans	human	NOUN
gs-4426	47	28	.	.	PUNCT
gs-4426	48	1	this	this	DET
gs-4426	48	2	initial	initial	ADJ
gs-4426	48	3	success	success	NOUN
gs-4426	48	4	generated	generate	VERB
gs-4426	48	5	substantial	substantial	ADJ
gs-4426	48	6	enthusiasm	enthusiasm	NOUN
gs-4426	48	7	and	and	CCONJ
gs-4426	48	8	led	lead	VERB
gs-4426	48	9	to	to	ADP
gs-4426	48	10	rapid	rapid	ADJ
gs-4426	48	11	expansion	expansion	NOUN
gs-4426	48	12	of	of	ADP
gs-4426	48	13	clinical	clinical	ADJ
gs-4426	48	14	trials	trial	NOUN
gs-4426	48	15	across	across	ADP
gs-4426	48	16	multiple	multiple	ADJ
gs-4426	48	17	disease	disease	NOUN
gs-4426	48	18	indications	indication	NOUN
gs-4426	48	19	.	.	PUNCT
gs-4426	49	1	however	however	ADV
gs-4426	49	2	,	,	PUNCT
gs-4426	49	3	the	the	DET
gs-4426	49	4	field	field	NOUN
gs-4426	49	5	's	's	PART
gs-4426	49	6	early	early	ADJ
gs-4426	49	7	optimism	optimism	NOUN
gs-4426	49	8	was	be	AUX
gs-4426	49	9	subsequently	subsequently	ADV
gs-4426	49	10	challenged	challenge	VERB
gs-4426	49	11	by	by	ADP
gs-4426	49	12	limited	limited	ADJ
gs-4426	49	13	therapeutic	therapeutic	ADJ
gs-4426	49	14	efficacy	efficacy	NOUN
gs-4426	49	15	in	in	ADP
gs-4426	49	16	most	most	ADJ
gs-4426	49	17	trials	trial	NOUN
gs-4426	49	18	,	,	PUNCT
gs-4426	49	19	georgian	georgian	NOUN
gs-4426	49	20	scientists/	scientists/	NUM
gs-4426	49	21	.	.	PUNCT
gs-4426	50	1	7	7	NUM
gs-4426	50	2	n	n	DET
gs-4426	50	3	4	4	NUM
gs-4426	50	4	,	,	PUNCT
gs-4426	50	5	2025	2025	NUM
gs-4426	50	6	596	596	NUM
gs-4426	50	7	reflecting	reflect	VERB
gs-4426	50	8	inadequate	inadequate	ADJ
gs-4426	50	9	understanding	understanding	NOUN
gs-4426	50	10	of	of	ADP
gs-4426	50	11	vector	vector	NOUN
gs-4426	50	12	biology	biology	NOUN
gs-4426	50	13	,	,	PUNCT
gs-4426	50	14	transgene	transgene	ADJ
gs-4426	50	15	expression	expression	NOUN
gs-4426	50	16	regulation	regulation	NOUN
gs-4426	50	17	,	,	PUNCT
gs-4426	50	18	and	and	CCONJ
gs-4426	50	19	immune	immune	ADJ
gs-4426	50	20	responses	response	NOUN
gs-4426	50	21	to	to	ADP
gs-4426	50	22	viral	viral	ADJ
gs-4426	50	23	vectors	vector	NOUN
gs-4426	50	24	and	and	CCONJ
gs-4426	50	25	transgene	transgene	ADJ
gs-4426	50	26	products	product	NOUN
gs-4426	50	27	.	.	PUNCT
gs-4426	51	1	the	the	DET
gs-4426	51	2	gene	gene	NOUN
gs-4426	51	3	therapy	therapy	NOUN
gs-4426	51	4	field	field	NOUN
gs-4426	51	5	experienced	experience	VERB
gs-4426	51	6	a	a	DET
gs-4426	51	7	profound	profound	ADJ
gs-4426	51	8	setback	setback	NOUN
gs-4426	51	9	in	in	ADP
gs-4426	51	10	1999	1999	NUM
gs-4426	51	11	following	follow	VERB
gs-4426	51	12	the	the	DET
gs-4426	51	13	death	death	NOUN
gs-4426	51	14	of	of	ADP
gs-4426	51	15	jesse	jesse	PROPN
gs-4426	51	16	gelsinger	gelsinger	PROPN
gs-4426	51	17	,	,	PUNCT
gs-4426	51	18	an	an	DET
gs-4426	51	19	18	18	NUM
gs-4426	51	20	-	-	PUNCT
gs-4426	51	21	year	year	NOUN
gs-4426	51	22	-	-	PUNCT
gs-4426	51	23	old	old	ADJ
gs-4426	51	24	participant	participant	NOUN
gs-4426	51	25	in	in	ADP
gs-4426	51	26	a	a	DET
gs-4426	51	27	clinical	clinical	ADJ
gs-4426	51	28	trial	trial	NOUN
gs-4426	51	29	for	for	ADP
gs-4426	51	30	ornithine	ornithine	ADJ
gs-4426	51	31	transcarbamylase	transcarbamylase	NOUN
gs-4426	51	32	deficiency	deficiency	NOUN
gs-4426	51	33	.	.	PUNCT
gs-4426	52	1	the	the	DET
gs-4426	52	2	patient	patient	NOUN
gs-4426	52	3	died	die	VERB
gs-4426	52	4	from	from	ADP
gs-4426	52	5	a	a	DET
gs-4426	52	6	systemic	systemic	ADJ
gs-4426	52	7	inflammatory	inflammatory	ADJ
gs-4426	52	8	response	response	NOUN
gs-4426	52	9	triggered	trigger	VERB
gs-4426	52	10	by	by	ADP
gs-4426	52	11	a	a	DET
gs-4426	52	12	high	high	ADV
gs-4426	52	13	-	-	PUNCT
gs-4426	52	14	dose	dose	VERB
gs-4426	52	15	adenoviral	adenoviral	ADJ
gs-4426	52	16	vector	vector	PROPN
gs-4426	52	17	administration	administration	NOUN
gs-4426	52	18	,	,	PUNCT
gs-4426	52	19	leading	lead	VERB
gs-4426	52	20	to	to	ADP
gs-4426	52	21	multiple	multiple	ADJ
gs-4426	52	22	organ	organ	NOUN
gs-4426	52	23	failure	failure	NOUN
gs-4426	52	24	.	.	PUNCT
gs-4426	53	1	this	this	DET
gs-4426	53	2	tragedy	tragedy	NOUN
gs-4426	53	3	prompted	prompt	VERB
gs-4426	53	4	comprehensive	comprehensive	ADJ
gs-4426	53	5	reassessment	reassessment	NOUN
gs-4426	53	6	of	of	ADP
gs-4426	53	7	gene	gene	NOUN
gs-4426	53	8	therapy	therapy	NOUN
gs-4426	53	9	safety	safety	NOUN
gs-4426	53	10	protocols	protocol	NOUN
gs-4426	53	11	,	,	PUNCT
gs-4426	53	12	informed	inform	VERB
gs-4426	53	13	consent	consent	NOUN
gs-4426	53	14	procedures	procedure	NOUN
gs-4426	53	15	,	,	PUNCT
gs-4426	53	16	and	and	CCONJ
gs-4426	53	17	regulatory	regulatory	ADJ
gs-4426	53	18	oversight	oversight	NOUN
gs-4426	53	19	mechanisms	mechanism	NOUN
gs-4426	53	20	.	.	PUNCT
gs-4426	54	1	the	the	DET
gs-4426	54	2	incident	incident	NOUN
gs-4426	54	3	resulted	result	VERB
gs-4426	54	4	in	in	ADP
gs-4426	54	5	increased	increase	VERB
gs-4426	54	6	scrutiny	scrutiny	NOUN
gs-4426	54	7	of	of	ADP
gs-4426	54	8	clinical	clinical	ADJ
gs-4426	54	9	trial	trial	NOUN
gs-4426	54	10	designs	design	NOUN
gs-4426	54	11	,	,	PUNCT
gs-4426	54	12	implementation	implementation	NOUN
gs-4426	54	13	of	of	ADP
gs-4426	54	14	more	more	ADV
gs-4426	54	15	stringent	stringent	ADJ
gs-4426	54	16	safety	safety	NOUN
gs-4426	54	17	monitoring	monitoring	NOUN
gs-4426	54	18	requirements	requirement	NOUN
gs-4426	54	19	,	,	PUNCT
gs-4426	54	20	and	and	CCONJ
gs-4426	54	21	recognition	recognition	NOUN
gs-4426	54	22	that	that	SCONJ
gs-4426	54	23	achieving	achieve	VERB
gs-4426	54	24	therapeutic	therapeutic	ADJ
gs-4426	54	25	efficacy	efficacy	NOUN
gs-4426	54	26	while	while	SCONJ
gs-4426	54	27	maintaining	maintain	VERB
gs-4426	54	28	safety	safety	NOUN
gs-4426	54	29	required	require	VERB
gs-4426	54	30	deeper	deep	ADJ
gs-4426	54	31	understanding	understanding	NOUN
gs-4426	54	32	of	of	ADP
gs-4426	54	33	vector	vector	NOUN
gs-4426	54	34	immunology	immunology	NOUN
gs-4426	54	35	and	and	CCONJ
gs-4426	54	36	dose	dose	NOUN
gs-4426	54	37	optimization	optimization	NOUN
gs-4426	54	38	.	.	PUNCT
gs-4426	55	1	the	the	DET
gs-4426	55	2	field	field	NOUN
gs-4426	55	3	entered	enter	VERB
gs-4426	55	4	a	a	DET
gs-4426	55	5	period	period	NOUN
gs-4426	55	6	of	of	ADP
gs-4426	55	7	cautious	cautious	ADJ
gs-4426	55	8	retrenchment	retrenchment	NOUN
gs-4426	55	9	characterized	characterize	VERB
gs-4426	55	10	by	by	ADP
gs-4426	55	11	enhanced	enhance	VERB
gs-4426	55	12	regulatory	regulatory	ADJ
gs-4426	55	13	requirements	requirement	NOUN
gs-4426	55	14	and	and	CCONJ
gs-4426	55	15	more	more	ADJ
gs-4426	55	16	conservative	conservative	ADJ
gs-4426	55	17	trial	trial	NOUN
gs-4426	55	18	designs	design	NOUN
gs-4426	55	19	.	.	PUNCT
gs-4426	56	1	a	a	DET
gs-4426	56	2	second	second	ADJ
gs-4426	56	3	major	major	ADJ
gs-4426	56	4	safety	safety	NOUN
gs-4426	56	5	concern	concern	NOUN
gs-4426	56	6	emerged	emerge	VERB
gs-4426	56	7	in	in	ADP
gs-4426	56	8	the	the	DET
gs-4426	56	9	early	early	ADJ
gs-4426	56	10	2000s	2000s	NUM
gs-4426	56	11	when	when	SCONJ
gs-4426	56	12	several	several	ADJ
gs-4426	56	13	patients	patient	NOUN
gs-4426	56	14	in	in	ADP
gs-4426	56	15	x	x	VERB
gs-4426	56	16	-	-	VERB
gs-4426	56	17	linked	link	VERB
gs-4426	56	18	severe	severe	ADJ
gs-4426	56	19	combined	combined	ADJ
gs-4426	56	20	immunodeficiency	immunodeficiency	NOUN
gs-4426	56	21	(	(	PUNCT
gs-4426	56	22	scid	scid	PROPN
gs-4426	56	23	-	-	PUNCT
gs-4426	56	24	x1	x1	PROPN
gs-4426	56	25	)	)	PUNCT
gs-4426	56	26	gene	gene	NOUN
gs-4426	56	27	therapy	therapy	NOUN
gs-4426	56	28	trials	trial	NOUN
gs-4426	56	29	developed	develop	VERB
gs-4426	56	30	t	t	PROPN
gs-4426	56	31	-	-	PUNCT
gs-4426	56	32	cell	cell	NOUN
gs-4426	56	33	leukemia	leukemia	NOUN
gs-4426	56	34	due	due	ADP
gs-4426	56	35	to	to	ADP
gs-4426	56	36	insertional	insertional	ADJ
gs-4426	56	37	mutagenesis	mutagenesis	NOUN
gs-4426	56	38	.	.	PUNCT
gs-4426	57	1	the	the	DET
gs-4426	57	2	retroviral	retroviral	ADJ
gs-4426	57	3	vectors	vector	NOUN
gs-4426	57	4	used	use	VERB
gs-4426	57	5	in	in	ADP
gs-4426	57	6	these	these	DET
gs-4426	57	7	trials	trial	NOUN
gs-4426	57	8	integrated	integrate	VERB
gs-4426	57	9	near	near	ADP
gs-4426	57	10	proto	proto	NOUN
gs-4426	57	11	-	-	PUNCT
gs-4426	57	12	oncogenes	oncogene	NOUN
gs-4426	57	13	,	,	PUNCT
gs-4426	57	14	leading	lead	VERB
gs-4426	57	15	to	to	ADP
gs-4426	57	16	aberrant	aberrant	ADJ
gs-4426	57	17	activation	activation	NOUN
gs-4426	57	18	and	and	CCONJ
gs-4426	57	19	clonal	clonal	ADJ
gs-4426	57	20	expansion	expansion	NOUN
gs-4426	57	21	of	of	ADP
gs-4426	57	22	transformed	transform	VERB
gs-4426	57	23	cells	cell	NOUN
gs-4426	57	24	(	(	PUNCT
gs-4426	57	25	kumar	kumar	PROPN
gs-4426	57	26	et	et	PROPN
gs-4426	57	27	al	al	PROPN
gs-4426	57	28	.	.	PROPN
gs-4426	57	29	,	,	PUNCT
gs-4426	57	30	2016	2016	NUM
gs-4426	57	31	)	)	PUNCT
gs-4426	57	32	.	.	PUNCT
gs-4426	58	1	these	these	DET
gs-4426	58	2	cases	case	NOUN
gs-4426	58	3	highlighted	highlight	VERB
gs-4426	58	4	the	the	DET
gs-4426	58	5	genotoxic	genotoxic	ADJ
gs-4426	58	6	potential	potential	NOUN
gs-4426	58	7	of	of	ADP
gs-4426	58	8	integrating	integrate	VERB
gs-4426	58	9	vectors	vector	NOUN
gs-4426	58	10	and	and	CCONJ
gs-4426	58	11	prompted	prompt	VERB
gs-4426	58	12	development	development	NOUN
gs-4426	58	13	of	of	ADP
gs-4426	58	14	safer	safe	ADJ
gs-4426	58	15	vector	vector	NOUN
gs-4426	58	16	designs	design	NOUN
gs-4426	58	17	incorporating	incorporate	VERB
gs-4426	58	18	self	self	NOUN
gs-4426	58	19	-	-	PUNCT
gs-4426	58	20	inactivating	inactivate	VERB
gs-4426	58	21	modifications	modification	NOUN
gs-4426	58	22	and	and	CCONJ
gs-4426	58	23	insulator	insulator	NOUN
gs-4426	58	24	elements	element	NOUN
gs-4426	58	25	to	to	PART
gs-4426	58	26	minimize	minimize	VERB
gs-4426	58	27	enhancer	enhancer	NOUN
gs-4426	58	28	-	-	PUNCT
gs-4426	58	29	mediated	mediate	VERB
gs-4426	58	30	activation	activation	NOUN
gs-4426	58	31	of	of	ADP
gs-4426	58	32	flanking	flank	VERB
gs-4426	58	33	genes	gene	NOUN
gs-4426	58	34	.	.	PUNCT
gs-4426	59	1	despite	despite	SCONJ
gs-4426	59	2	these	these	DET
gs-4426	59	3	setbacks	setback	NOUN
gs-4426	59	4	,	,	PUNCT
gs-4426	59	5	the	the	DET
gs-4426	59	6	scid	scid	PROPN
gs-4426	59	7	-	-	PUNCT
gs-4426	59	8	x1	x1	ADJ
gs-4426	59	9	trials	trial	NOUN
gs-4426	59	10	also	also	ADV
gs-4426	59	11	demonstrated	demonstrate	VERB
gs-4426	59	12	that	that	SCONJ
gs-4426	59	13	gene	gene	NOUN
gs-4426	59	14	therapy	therapy	NOUN
gs-4426	59	15	could	could	AUX
gs-4426	59	16	achieve	achieve	VERB
gs-4426	59	17	functional	functional	ADJ
gs-4426	59	18	cures	cure	NOUN
gs-4426	59	19	,	,	PUNCT
gs-4426	59	20	as	as	SCONJ
gs-4426	59	21	many	many	ADJ
gs-4426	59	22	treated	treat	VERB
gs-4426	59	23	patients	patient	NOUN
gs-4426	59	24	experienced	experience	VERB
gs-4426	59	25	sustained	sustain	VERB
gs-4426	59	26	immune	immune	ADJ
gs-4426	59	27	reconstitution	reconstitution	NOUN
gs-4426	59	28	and	and	CCONJ
gs-4426	59	29	lived	live	VERB
gs-4426	59	30	normal	normal	ADJ
gs-4426	59	31	lives	life	NOUN
gs-4426	59	32	without	without	ADP
gs-4426	59	33	requiring	require	VERB
gs-4426	59	34	bone	bone	NOUN
gs-4426	59	35	marrow	marrow	NOUN
gs-4426	59	36	transplantation	transplantation	NOUN
gs-4426	59	37	.	.	PUNCT
gs-4426	60	1	this	this	DET
gs-4426	60	2	dual	dual	ADJ
gs-4426	60	3	outcome	outcome	NOUN
gs-4426	60	4	—	—	PUNCT
gs-4426	60	5	clinical	clinical	ADJ
gs-4426	60	6	efficacy	efficacy	NOUN
gs-4426	60	7	coupled	couple	VERB
gs-4426	60	8	with	with	ADP
gs-4426	60	9	serious	serious	ADJ
gs-4426	60	10	adverse	adverse	ADJ
gs-4426	60	11	events	event	NOUN
gs-4426	60	12	—	—	PUNCT
gs-4426	60	13	catalyzed	catalyze	VERB
gs-4426	60	14	innovations	innovation	NOUN
gs-4426	60	15	in	in	ADP
gs-4426	60	16	vector	vector	NOUN
gs-4426	60	17	safety	safety	NOUN
gs-4426	60	18	while	while	SCONJ
gs-4426	60	19	validating	validate	VERB
gs-4426	60	20	the	the	DET
gs-4426	60	21	therapeutic	therapeutic	ADJ
gs-4426	60	22	potential	potential	NOUN
gs-4426	60	23	of	of	ADP
gs-4426	60	24	genetic	genetic	ADJ
gs-4426	60	25	correction	correction	NOUN
gs-4426	60	26	.	.	PUNCT
gs-4426	61	1	regulatory	regulatory	ADJ
gs-4426	61	2	evolution	evolution	NOUN
gs-4426	61	3	and	and	CCONJ
gs-4426	61	4	approval	approval	NOUN
gs-4426	61	5	milestones	milestone	NOUN
gs-4426	61	6	the	the	DET
gs-4426	61	7	regulatory	regulatory	ADJ
gs-4426	61	8	landscape	landscape	NOUN
gs-4426	61	9	for	for	ADP
gs-4426	61	10	gene	gene	NOUN
gs-4426	61	11	therapy	therapy	NOUN
gs-4426	61	12	has	have	AUX
gs-4426	61	13	evolved	evolve	VERB
gs-4426	61	14	substantially	substantially	ADV
gs-4426	61	15	to	to	PART
gs-4426	61	16	accommodate	accommodate	VERB
gs-4426	61	17	the	the	DET
gs-4426	61	18	unique	unique	ADJ
gs-4426	61	19	characteristics	characteristic	NOUN
gs-4426	61	20	of	of	ADP
gs-4426	61	21	genetic	genetic	ADJ
gs-4426	61	22	medicines	medicine	NOUN
gs-4426	61	23	while	while	SCONJ
gs-4426	61	24	maintaining	maintain	VERB
gs-4426	61	25	appropriate	appropriate	ADJ
gs-4426	61	26	safety	safety	NOUN
gs-4426	61	27	oversight	oversight	NOUN
gs-4426	61	28	.	.	PUNCT
gs-4426	62	1	early	early	ADJ
gs-4426	62	2	gene	gene	NOUN
gs-4426	62	3	therapy	therapy	NOUN
gs-4426	62	4	trials	trial	NOUN
gs-4426	62	5	operated	operate	VERB
gs-4426	62	6	under	under	ADP
gs-4426	62	7	traditional	traditional	ADJ
gs-4426	62	8	drug	drug	NOUN
gs-4426	62	9	development	development	NOUN
gs-4426	62	10	paradigms	paradigm	NOUN
gs-4426	62	11	that	that	PRON
gs-4426	62	12	proved	prove	VERB
gs-4426	62	13	inadequate	inadequate	ADJ
gs-4426	62	14	for	for	ADP
gs-4426	62	15	biological	biological	ADJ
gs-4426	62	16	products	product	NOUN
gs-4426	62	17	with	with	ADP
gs-4426	62	18	complex	complex	ADJ
gs-4426	62	19	mechanisms	mechanism	NOUN
gs-4426	62	20	,	,	PUNCT
gs-4426	62	21	long	long	ADV
gs-4426	62	22	-	-	PUNCT
gs-4426	62	23	lasting	last	VERB
gs-4426	62	24	effects	effect	NOUN
gs-4426	62	25	,	,	PUNCT
gs-4426	62	26	and	and	CCONJ
gs-4426	62	27	heterogeneous	heterogeneous	ADJ
gs-4426	62	28	patient	patient	NOUN
gs-4426	62	29	responses	response	NOUN
gs-4426	62	30	.	.	PUNCT
gs-4426	63	1	regulatory	regulatory	ADJ
gs-4426	63	2	agencies	agency	NOUN
gs-4426	63	3	including	include	VERB
gs-4426	63	4	the	the	DET
gs-4426	63	5	fda	fda	PROPN
gs-4426	63	6	,	,	PUNCT
gs-4426	63	7	european	european	PROPN
gs-4426	63	8	medicines	medicine	NOUN
gs-4426	63	9	agency	agency	NOUN
gs-4426	63	10	(	(	PUNCT
gs-4426	63	11	ema	ema	PROPN
gs-4426	63	12	)	)	PUNCT
gs-4426	63	13	,	,	PUNCT
gs-4426	63	14	and	and	CCONJ
gs-4426	63	15	others	other	NOUN
gs-4426	63	16	developed	develop	VERB
gs-4426	63	17	specialized	specialized	ADJ
gs-4426	63	18	frameworks	framework	NOUN
gs-4426	63	19	recognizing	recognize	VERB
gs-4426	63	20	gene	gene	NOUN
gs-4426	63	21	therapy	therapy	NOUN
gs-4426	63	22	's	's	PART
gs-4426	63	23	distinctive	distinctive	ADJ
gs-4426	63	24	features	feature	NOUN
gs-4426	63	25	,	,	PUNCT
gs-4426	63	26	including	include	VERB
gs-4426	63	27	establishment	establishment	NOUN
gs-4426	63	28	of	of	ADP
gs-4426	63	29	dedicated	dedicated	ADJ
gs-4426	63	30	article	article	NOUN
gs-4426	63	31	divisions	division	NOUN
gs-4426	63	32	,	,	PUNCT
gs-4426	63	33	creation	creation	NOUN
gs-4426	63	34	of	of	ADP
gs-4426	63	35	gene	gene	NOUN
gs-4426	63	36	therapy	therapy	NOUN
gs-4426	63	37	-	-	PUNCT
gs-4426	63	38	specific	specific	ADJ
gs-4426	63	39	guidance	guidance	NOUN
gs-4426	63	40	documents	document	NOUN
gs-4426	63	41	,	,	PUNCT
gs-4426	63	42	and	and	CCONJ
gs-4426	63	43	implementation	implementation	NOUN
gs-4426	63	44	of	of	ADP
gs-4426	63	45	long	long	ADJ
gs-4426	63	46	-	-	PUNCT
gs-4426	63	47	term	term	NOUN
gs-4426	63	48	follow	follow	NOUN
gs-4426	63	49	-	-	PUNCT
gs-4426	63	50	up	up	ADP
gs-4426	63	51	requirements	requirement	NOUN
gs-4426	63	52	extending	extend	VERB
gs-4426	63	53	up	up	ADP
gs-4426	63	54	to	to	PART
gs-4426	63	55	fifteen	fifteen	NUM
gs-4426	63	56	years	year	NOUN
gs-4426	63	57	posttreatment	posttreatment	NOUN
gs-4426	63	58	.	.	PUNCT
gs-4426	64	1	these	these	DET
gs-4426	64	2	frameworks	framework	NOUN
gs-4426	64	3	balance	balance	VERB
gs-4426	64	4	the	the	DET
gs-4426	64	5	need	need	NOUN
gs-4426	64	6	for	for	ADP
gs-4426	64	7	rigorous	rigorous	ADJ
gs-4426	64	8	safety	safety	NOUN
gs-4426	64	9	evaluation	evaluation	NOUN
gs-4426	64	10	against	against	ADP
gs-4426	64	11	the	the	DET
gs-4426	64	12	urgency	urgency	NOUN
gs-4426	64	13	of	of	ADP
gs-4426	64	14	addressing	address	VERB
gs-4426	64	15	life	life	NOUN
gs-4426	64	16	-	-	PUNCT
gs-4426	64	17	threatening	threaten	VERB
gs-4426	64	18	conditions	condition	NOUN
gs-4426	64	19	with	with	ADP
gs-4426	64	20	limited	limited	ADJ
gs-4426	64	21	therapeutic	therapeutic	ADJ
gs-4426	64	22	alternatives	alternative	NOUN
gs-4426	64	23	.	.	PUNCT
gs-4426	65	1	the	the	DET
gs-4426	65	2	first	first	ADJ
gs-4426	65	3	gene	gene	NOUN
gs-4426	65	4	therapy	therapy	NOUN
gs-4426	65	5	approval	approval	NOUN
gs-4426	65	6	in	in	ADP
gs-4426	65	7	the	the	DET
gs-4426	65	8	western	western	ADJ
gs-4426	65	9	world	world	NOUN
gs-4426	65	10	occurred	occur	VERB
gs-4426	65	11	in	in	ADP
gs-4426	65	12	2012	2012	NUM
gs-4426	65	13	when	when	SCONJ
gs-4426	65	14	the	the	DET
gs-4426	65	15	ema	ema	PROPN
gs-4426	65	16	approved	approve	VERB
gs-4426	65	17	glybera	glybera	NOUN
gs-4426	65	18	(	(	PUNCT
gs-4426	65	19	alipogene	alipogene	NOUN
gs-4426	65	20	tiparvovec	tiparvovec	PROPN
gs-4426	65	21	)	)	PUNCT
gs-4426	65	22	for	for	ADP
gs-4426	65	23	lipoprotein	lipoprotein	ADJ
gs-4426	65	24	lipase	lipase	NOUN
gs-4426	65	25	deficiency	deficiency	NOUN
gs-4426	65	26	,	,	PUNCT
gs-4426	65	27	an	an	DET
gs-4426	65	28	ultra	ultra	ADJ
gs-4426	65	29	-	-	ADJ
gs-4426	65	30	rare	rare	ADJ
gs-4426	65	31	metabolic	metabolic	NOUN
gs-4426	65	32	disorder	disorder	NOUN
gs-4426	65	33	.	.	PUNCT
gs-4426	66	1	despite	despite	SCONJ
gs-4426	66	2	its	its	PRON
gs-4426	66	3	landmark	landmark	NOUN
gs-4426	66	4	status	status	NOUN
gs-4426	66	5	as	as	ADP
gs-4426	66	6	the	the	DET
gs-4426	66	7	first	first	ADJ
gs-4426	66	8	approved	approve	VERB
gs-4426	66	9	gene	gene	NOUN
gs-4426	66	10	therapy	therapy	NOUN
gs-4426	66	11	,	,	PUNCT
gs-4426	66	12	glybera	glybera	NOUN
gs-4426	66	13	achieved	achieve	VERB
gs-4426	66	14	limited	limited	ADJ
gs-4426	66	15	commercial	commercial	ADJ
gs-4426	66	16	success	success	NOUN
gs-4426	66	17	due	due	ADP
gs-4426	66	18	to	to	ADP
gs-4426	66	19	its	its	PRON
gs-4426	66	20	extremely	extremely	ADV
gs-4426	66	21	high	high	ADJ
gs-4426	66	22	cost	cost	NOUN
gs-4426	66	23	(	(	PUNCT
gs-4426	66	24	approximately	approximately	ADV
gs-4426	66	25	one	one	NUM
gs-4426	66	26	million	million	NUM
gs-4426	66	27	euros	euro	NOUN
gs-4426	66	28	per	per	ADP
gs-4426	66	29	treatment	treatment	NOUN
gs-4426	66	30	)	)	PUNCT
gs-4426	66	31	,	,	PUNCT
gs-4426	66	32	tiny	tiny	ADJ
gs-4426	66	33	patient	patient	ADJ
gs-4426	66	34	population	population	NOUN
gs-4426	66	35	,	,	PUNCT
gs-4426	66	36	and	and	CCONJ
gs-4426	66	37	questions	question	NOUN
gs-4426	66	38	about	about	ADP
gs-4426	66	39	long	long	ADJ
gs-4426	66	40	-	-	PUNCT
gs-4426	66	41	term	term	NOUN
gs-4426	66	42	efficacy	efficacy	NOUN
gs-4426	66	43	.	.	PUNCT
gs-4426	67	1	the	the	DET
gs-4426	67	2	product	product	NOUN
gs-4426	67	3	was	be	AUX
gs-4426	67	4	withdrawn	withdraw	VERB
gs-4426	67	5	from	from	ADP
gs-4426	67	6	the	the	DET
gs-4426	67	7	market	market	NOUN
gs-4426	67	8	in	in	ADP
gs-4426	67	9	2017	2017	NUM
gs-4426	67	10	,	,	PUNCT
gs-4426	67	11	highlighting	highlight	VERB
gs-4426	67	12	challenges	challenge	NOUN
gs-4426	67	13	in	in	ADP
gs-4426	67	14	developing	develop	VERB
gs-4426	67	15	economically	economically	ADV
gs-4426	67	16	sustainable	sustainable	ADJ
gs-4426	67	17	gene	gene	NOUN
gs-4426	67	18	therapies	therapy	NOUN
gs-4426	67	19	for	for	ADP
gs-4426	67	20	ultrarare	ultrarare	NOUN
gs-4426	67	21	diseases	disease	NOUN
gs-4426	67	22	.	.	PUNCT
gs-4426	68	1	nevertheless	nevertheless	ADV
gs-4426	68	2	,	,	PUNCT
gs-4426	68	3	glybera	glybera	NOUN
gs-4426	68	4	's	's	PART
gs-4426	68	5	approval	approval	NOUN
gs-4426	68	6	established	establish	VERB
gs-4426	68	7	important	important	ADJ
gs-4426	68	8	regulatory	regulatory	ADJ
gs-4426	68	9	precedents	precedent	NOUN
gs-4426	68	10	,	,	PUNCT
gs-4426	68	11	georgian	georgian	NOUN
gs-4426	68	12	scientists/	scientists/	NUM
gs-4426	68	13	.	.	PUNCT
gs-4426	69	1	7	7	NUM
gs-4426	69	2	n	n	DET
gs-4426	69	3	4	4	NUM
gs-4426	69	4	,	,	PUNCT
gs-4426	69	5	2025	2025	NUM
gs-4426	69	6	597	597	NUM
gs-4426	69	7	including	include	VERB
gs-4426	69	8	acceptance	acceptance	NOUN
gs-4426	69	9	of	of	ADP
gs-4426	69	10	small	small	ADJ
gs-4426	69	11	patient	patient	ADJ
gs-4426	69	12	numbers	number	NOUN
gs-4426	69	13	for	for	ADP
gs-4426	69	14	rare	rare	ADJ
gs-4426	69	15	disease	disease	NOUN
gs-4426	69	16	indications	indication	NOUN
gs-4426	69	17	,	,	PUNCT
gs-4426	69	18	use	use	NOUN
gs-4426	69	19	of	of	ADP
gs-4426	69	20	surrogate	surrogate	ADJ
gs-4426	69	21	endpoints	endpoint	NOUN
gs-4426	69	22	when	when	SCONJ
gs-4426	69	23	measuring	measure	VERB
gs-4426	69	24	clinical	clinical	ADJ
gs-4426	69	25	benefit	benefit	NOUN
gs-4426	69	26	over	over	ADP
gs-4426	69	27	extended	extended	ADJ
gs-4426	69	28	timeframes	timeframe	NOUN
gs-4426	69	29	,	,	PUNCT
gs-4426	69	30	and	and	CCONJ
gs-4426	69	31	recognition	recognition	NOUN
gs-4426	69	32	that	that	SCONJ
gs-4426	69	33	singleadministration	singleadministration	NOUN
gs-4426	69	34	curative	curative	ADJ
gs-4426	69	35	therapies	therapy	NOUN
gs-4426	69	36	warrant	warrant	VERB
gs-4426	69	37	different	different	ADJ
gs-4426	69	38	health	health	NOUN
gs-4426	69	39	economic	economic	ADJ
gs-4426	69	40	evaluations	evaluation	NOUN
gs-4426	69	41	than	than	ADP
gs-4426	69	42	chronic	chronic	ADJ
gs-4426	69	43	treatments	treatment	NOUN
gs-4426	69	44	.	.	PUNCT
gs-4426	70	1	the	the	DET
gs-4426	70	2	year	year	NOUN
gs-4426	70	3	2017	2017	NUM
gs-4426	70	4	marked	mark	VERB
gs-4426	70	5	a	a	DET
gs-4426	70	6	transformative	transformative	ADJ
gs-4426	70	7	milestone	milestone	NOUN
gs-4426	70	8	with	with	ADP
gs-4426	70	9	three	three	NUM
gs-4426	70	10	landmark	landmark	PROPN
gs-4426	70	11	fda	fda	PROPN
gs-4426	70	12	approvals	approval	NOUN
gs-4426	70	13	that	that	SCONJ
gs-4426	70	14	validated	validated	ADJ
gs-4426	70	15	gene	gene	NOUN
gs-4426	70	16	therapy	therapy	NOUN
gs-4426	70	17	's	's	PART
gs-4426	70	18	clinical	clinical	ADJ
gs-4426	70	19	potential	potential	NOUN
gs-4426	70	20	and	and	CCONJ
gs-4426	70	21	established	establish	VERB
gs-4426	70	22	viable	viable	ADJ
gs-4426	70	23	commercial	commercial	ADJ
gs-4426	70	24	frameworks	framework	NOUN
gs-4426	70	25	.	.	PUNCT
gs-4426	71	1	kymriah	kymriah	PROPN
gs-4426	71	2	(	(	PUNCT
gs-4426	71	3	tisagenlecleucel	tisagenlecleucel	PROPN
gs-4426	71	4	)	)	PUNCT
gs-4426	71	5	and	and	CCONJ
gs-4426	71	6	yescarta	yescarta	PROPN
gs-4426	71	7	(	(	PUNCT
gs-4426	71	8	axicabtagene	axicabtagene	PROPN
gs-4426	71	9	ciloleucel	ciloleucel	PROPN
gs-4426	71	10	)	)	PUNCT
gs-4426	71	11	,	,	PUNCT
gs-4426	71	12	two	two	NUM
gs-4426	71	13	cd19	cd19	PROPN
gs-4426	71	14	-	-	PUNCT
gs-4426	71	15	directed	direct	VERB
gs-4426	71	16	car	car	NOUN
gs-4426	71	17	-	-	PUNCT
gs-4426	71	18	t	t	NOUN
gs-4426	71	19	cell	cell	NOUN
gs-4426	71	20	therapies	therapy	NOUN
gs-4426	71	21	for	for	ADP
gs-4426	71	22	hematological	hematological	ADJ
gs-4426	71	23	malignancies	malignancy	NOUN
gs-4426	71	24	,	,	PUNCT
gs-4426	71	25	demonstrated	demonstrate	VERB
gs-4426	71	26	unprecedented	unprecedented	ADJ
gs-4426	71	27	response	response	NOUN
gs-4426	71	28	rates	rate	NOUN
gs-4426	71	29	in	in	ADP
gs-4426	71	30	patients	patient	NOUN
gs-4426	71	31	with	with	ADP
gs-4426	71	32	refractory	refractory	NOUN
gs-4426	71	33	b	b	NOUN
gs-4426	71	34	-	-	PUNCT
gs-4426	71	35	cell	cell	NOUN
gs-4426	71	36	lymphomas	lymphoma	NOUN
gs-4426	71	37	and	and	CCONJ
gs-4426	71	38	leukemias	leukemia	NOUN
gs-4426	71	39	.	.	PUNCT
gs-4426	72	1	these	these	DET
gs-4426	72	2	approvals	approval	NOUN
gs-4426	72	3	established	establish	VERB
gs-4426	72	4	regulatory	regulatory	ADJ
gs-4426	72	5	pathways	pathway	NOUN
gs-4426	72	6	for	for	ADP
gs-4426	72	7	genetically	genetically	ADV
gs-4426	72	8	modified	modify	VERB
gs-4426	72	9	autologous	autologous	ADJ
gs-4426	72	10	cellular	cellular	ADJ
gs-4426	72	11	products	product	NOUN
gs-4426	72	12	and	and	CCONJ
gs-4426	72	13	prompted	prompt	VERB
gs-4426	72	14	development	development	NOUN
gs-4426	72	15	of	of	ADP
gs-4426	72	16	risk	risk	NOUN
gs-4426	72	17	management	management	NOUN
gs-4426	72	18	strategies	strategy	NOUN
gs-4426	72	19	addressing	address	VERB
gs-4426	72	20	unique	unique	ADJ
gs-4426	72	21	toxicities	toxicity	NOUN
gs-4426	72	22	including	include	VERB
gs-4426	72	23	cytokine	cytokine	ADJ
gs-4426	72	24	release	release	NOUN
gs-4426	72	25	syndrome	syndrome	NOUN
gs-4426	72	26	and	and	CCONJ
gs-4426	72	27	immune	immune	ADJ
gs-4426	72	28	effector	effector	NOUN
gs-4426	72	29	cell	cell	NOUN
gs-4426	72	30	-	-	PUNCT
gs-4426	72	31	associated	associate	VERB
gs-4426	72	32	neurotoxicity	neurotoxicity	NOUN
gs-4426	72	33	syndrome	syndrome	NOUN
gs-4426	72	34	.	.	PUNCT
gs-4426	73	1	luxturna	luxturna	NOUN
gs-4426	73	2	(	(	PUNCT
gs-4426	73	3	voretigene	voretigene	ADJ
gs-4426	73	4	neparvovec	neparvovec	NOUN
gs-4426	73	5	-	-	PUNCT
gs-4426	73	6	rzyl	rzyl	NOUN
gs-4426	73	7	)	)	PUNCT
gs-4426	73	8	,	,	PUNCT
gs-4426	73	9	an	an	DET
gs-4426	73	10	aav2	aav2	NOUN
gs-4426	73	11	-	-	PUNCT
gs-4426	73	12	based	base	VERB
gs-4426	73	13	gene	gene	NOUN
gs-4426	73	14	therapy	therapy	NOUN
gs-4426	73	15	for	for	ADP
gs-4426	73	16	rpe65	rpe65	PROPN
gs-4426	73	17	mutation	mutation	NOUN
gs-4426	73	18	-	-	PUNCT
gs-4426	73	19	associated	associate	VERB
gs-4426	73	20	retinal	retinal	ADJ
gs-4426	73	21	dystrophy	dystrophy	NOUN
gs-4426	73	22	,	,	PUNCT
gs-4426	73	23	became	become	VERB
gs-4426	73	24	the	the	DET
gs-4426	73	25	first	first	ADJ
gs-4426	73	26	approved	approve	VERB
gs-4426	73	27	in	in	ADP
gs-4426	73	28	vivo	vivo	ADJ
gs-4426	73	29	gene	gene	NOUN
gs-4426	73	30	therapy	therapy	NOUN
gs-4426	73	31	in	in	ADP
gs-4426	73	32	the	the	DET
gs-4426	73	33	united	united	PROPN
gs-4426	73	34	states	states	PROPN
gs-4426	73	35	.	.	PUNCT
gs-4426	74	1	luxturna	luxturna	PROPN
gs-4426	74	2	's	's	PART
gs-4426	74	3	approval	approval	NOUN
gs-4426	74	4	demonstrated	demonstrate	VERB
gs-4426	74	5	that	that	SCONJ
gs-4426	74	6	direct	direct	ADJ
gs-4426	74	7	tissue	tissue	NOUN
gs-4426	74	8	delivery	delivery	NOUN
gs-4426	74	9	of	of	ADP
gs-4426	74	10	viral	viral	ADJ
gs-4426	74	11	vectors	vector	NOUN
gs-4426	74	12	could	could	AUX
gs-4426	74	13	achieve	achieve	VERB
gs-4426	74	14	durable	durable	ADJ
gs-4426	74	15	clinical	clinical	ADJ
gs-4426	74	16	benefit	benefit	NOUN
gs-4426	74	17	,	,	PUNCT
gs-4426	74	18	expanding	expand	VERB
gs-4426	74	19	gene	gene	NOUN
gs-4426	74	20	therapy	therapy	NOUN
gs-4426	74	21	applications	application	NOUN
gs-4426	74	22	beyond	beyond	ADP
gs-4426	74	23	ex	ex	PRON
gs-4426	74	24	vivo	vivo	NOUN
gs-4426	74	25	approaches	approach	NOUN
gs-4426	74	26	and	and	CCONJ
gs-4426	74	27	validating	validate	VERB
gs-4426	74	28	organ	organ	NOUN
gs-4426	74	29	-	-	PUNCT
gs-4426	74	30	directed	direct	VERB
gs-4426	74	31	gene	gene	NOUN
gs-4426	74	32	replacement	replacement	NOUN
gs-4426	74	33	strategies	strategy	NOUN
gs-4426	74	34	.	.	PUNCT
gs-4426	75	1	the	the	DET
gs-4426	75	2	subsequent	subsequent	ADJ
gs-4426	75	3	years	year	NOUN
gs-4426	75	4	witnessed	witness	VERB
gs-4426	75	5	accelerating	accelerate	VERB
gs-4426	75	6	approval	approval	NOUN
gs-4426	75	7	rates	rate	NOUN
gs-4426	75	8	as	as	SCONJ
gs-4426	75	9	the	the	DET
gs-4426	75	10	gene	gene	NOUN
gs-4426	75	11	therapy	therapy	NOUN
gs-4426	75	12	clinical	clinical	ADJ
gs-4426	75	13	pipeline	pipeline	NOUN
gs-4426	75	14	matured	mature	VERB
gs-4426	75	15	and	and	CCONJ
gs-4426	75	16	regulatory	regulatory	ADJ
gs-4426	75	17	familiarity	familiarity	NOUN
gs-4426	75	18	with	with	ADP
gs-4426	75	19	these	these	DET
gs-4426	75	20	therapeutic	therapeutic	ADJ
gs-4426	75	21	modalities	modality	NOUN
gs-4426	75	22	increased	increase	VERB
gs-4426	75	23	.	.	PUNCT
gs-4426	76	1	zolgensma	zolgensma	NOUN
gs-4426	76	2	(	(	PUNCT
gs-4426	76	3	onasemnogene	onasemnogene	PROPN
gs-4426	76	4	abeparvovec	abeparvovec	PROPN
gs-4426	76	5	-	-	PUNCT
gs-4426	76	6	xioi	xioi	PROPN
gs-4426	76	7	)	)	PUNCT
gs-4426	76	8	,	,	PUNCT
gs-4426	76	9	approved	approve	VERB
gs-4426	76	10	in	in	ADP
gs-4426	76	11	2019	2019	NUM
gs-4426	76	12	for	for	ADP
gs-4426	76	13	spinal	spinal	ADJ
gs-4426	76	14	muscular	muscular	ADJ
gs-4426	76	15	atrophy	atrophy	NOUN
gs-4426	76	16	type	type	NOUN
gs-4426	76	17	1	1	NUM
gs-4426	76	18	,	,	PUNCT
gs-4426	76	19	represented	represent	VERB
gs-4426	76	20	the	the	DET
gs-4426	76	21	first	first	ADJ
gs-4426	76	22	systemically	systemically	ADV
gs-4426	76	23	administered	administer	VERB
gs-4426	76	24	aav	aav	NOUN
gs-4426	76	25	gene	gene	NOUN
gs-4426	76	26	therapy	therapy	NOUN
gs-4426	76	27	for	for	ADP
gs-4426	76	28	a	a	DET
gs-4426	76	29	neurological	neurological	ADJ
gs-4426	76	30	disorder	disorder	NOUN
gs-4426	76	31	and	and	CCONJ
gs-4426	76	32	became	become	VERB
gs-4426	76	33	notable	notable	ADJ
gs-4426	76	34	as	as	ADP
gs-4426	76	35	the	the	DET
gs-4426	76	36	most	most	ADV
gs-4426	76	37	expensive	expensive	ADJ
gs-4426	76	38	single	single	ADJ
gs-4426	76	39	-	-	PUNCT
gs-4426	76	40	administration	administration	NOUN
gs-4426	76	41	drug	drug	NOUN
gs-4426	76	42	ever	ever	ADV
gs-4426	76	43	approved	approve	VERB
gs-4426	76	44	at	at	ADP
gs-4426	76	45	over	over	ADP
gs-4426	76	46	two	two	NUM
gs-4426	76	47	million	million	NUM
gs-4426	76	48	dollars	dollar	NOUN
gs-4426	76	49	.	.	PUNCT
gs-4426	77	1	additional	additional	ADJ
gs-4426	77	2	car	car	NOUN
gs-4426	77	3	-	-	PUNCT
gs-4426	77	4	t	t	NOUN
gs-4426	77	5	products	product	NOUN
gs-4426	77	6	received	receive	VERB
gs-4426	77	7	approval	approval	NOUN
gs-4426	77	8	for	for	ADP
gs-4426	77	9	various	various	ADJ
gs-4426	77	10	b	b	NOUN
gs-4426	77	11	-	-	PUNCT
gs-4426	77	12	cell	cell	NOUN
gs-4426	77	13	malignancies	malignancy	NOUN
gs-4426	77	14	,	,	PUNCT
gs-4426	77	15	while	while	SCONJ
gs-4426	77	16	gene	gene	NOUN
gs-4426	77	17	therapies	therapy	NOUN
gs-4426	77	18	for	for	ADP
gs-4426	77	19	hemophilia	hemophilia	NOUN
gs-4426	77	20	,	,	PUNCT
gs-4426	77	21	beta	beta	NOUN
gs-4426	77	22	thalassemia	thalassemia	NOUN
gs-4426	77	23	,	,	PUNCT
gs-4426	77	24	and	and	CCONJ
gs-4426	77	25	other	other	ADJ
gs-4426	77	26	blood	blood	NOUN
gs-4426	77	27	disorders	disorder	NOUN
gs-4426	77	28	progressed	progress	VERB
gs-4426	77	29	through	through	ADP
gs-4426	77	30	late	late	ADJ
gs-4426	77	31	-	-	PUNCT
gs-4426	77	32	stage	stage	NOUN
gs-4426	77	33	development	development	NOUN
gs-4426	77	34	.	.	PUNCT
gs-4426	78	1	the	the	DET
gs-4426	78	2	fda	fda	PROPN
gs-4426	78	3	's	's	PART
gs-4426	78	4	establishment	establishment	NOUN
gs-4426	78	5	of	of	ADP
gs-4426	78	6	the	the	DET
gs-4426	78	7	regenerative	regenerative	ADJ
gs-4426	78	8	medicine	medicine	NOUN
gs-4426	78	9	advanced	advanced	ADJ
gs-4426	78	10	therapy	therapy	NOUN
gs-4426	78	11	designation	designation	NOUN
gs-4426	78	12	and	and	CCONJ
gs-4426	78	13	accelerated	accelerate	VERB
gs-4426	78	14	approval	approval	NOUN
gs-4426	78	15	pathways	pathway	NOUN
gs-4426	78	16	facilitated	facilitate	VERB
gs-4426	78	17	rapid	rapid	ADJ
gs-4426	78	18	translation	translation	NOUN
gs-4426	78	19	of	of	ADP
gs-4426	78	20	promising	promising	ADJ
gs-4426	78	21	therapies	therapy	NOUN
gs-4426	78	22	,	,	PUNCT
gs-4426	78	23	particularly	particularly	ADV
gs-4426	78	24	for	for	ADP
gs-4426	78	25	serious	serious	ADJ
gs-4426	78	26	conditions	condition	NOUN
gs-4426	78	27	lacking	lack	VERB
gs-4426	78	28	adequate	adequate	ADJ
gs-4426	78	29	treatment	treatment	NOUN
gs-4426	78	30	options	option	NOUN
gs-4426	78	31	.	.	PUNCT
gs-4426	79	1	crispr	crispr	ADJ
gs-4426	79	2	technology	technology	NOUN
gs-4426	79	3	:	:	PUNCT
gs-4426	79	4	from	from	ADP
gs-4426	79	5	discovery	discovery	NOUN
gs-4426	79	6	to	to	ADP
gs-4426	79	7	clinical	clinical	ADJ
gs-4426	79	8	translation	translation	NOUN
gs-4426	79	9	the	the	DET
gs-4426	79	10	discovery	discovery	NOUN
gs-4426	79	11	and	and	CCONJ
gs-4426	79	12	rapid	rapid	ADJ
gs-4426	79	13	clinical	clinical	ADJ
gs-4426	79	14	translation	translation	NOUN
gs-4426	79	15	of	of	ADP
gs-4426	79	16	crispr	crispr	ADJ
gs-4426	79	17	-	-	PUNCT
gs-4426	79	18	cas	cas	NOUN
gs-4426	79	19	systems	system	NOUN
gs-4426	79	20	represents	represent	VERB
gs-4426	79	21	one	one	NUM
gs-4426	79	22	of	of	ADP
gs-4426	79	23	the	the	DET
gs-4426	79	24	most	most	ADV
gs-4426	79	25	remarkable	remarkable	ADJ
gs-4426	79	26	examples	example	NOUN
gs-4426	79	27	of	of	ADP
gs-4426	79	28	bench	bench	NOUN
gs-4426	79	29	-	-	PUNCT
gs-4426	79	30	to	to	ADP
gs-4426	79	31	-	-	PUNCT
gs-4426	79	32	bedside	bedside	NOUN
gs-4426	79	33	innovation	innovation	NOUN
gs-4426	79	34	in	in	ADP
gs-4426	79	35	biomedical	biomedical	ADJ
gs-4426	79	36	history	history	NOUN
gs-4426	79	37	.	.	PUNCT
gs-4426	80	1	the	the	DET
gs-4426	80	2	crispr	crispr	ADJ
gs-4426	80	3	system	system	NOUN
gs-4426	80	4	was	be	AUX
gs-4426	80	5	first	first	ADV
gs-4426	80	6	identified	identify	VERB
gs-4426	80	7	in	in	ADP
gs-4426	80	8	bacteria	bacteria	NOUN
gs-4426	80	9	as	as	ADP
gs-4426	80	10	an	an	DET
gs-4426	80	11	adaptive	adaptive	ADJ
gs-4426	80	12	immune	immune	ADJ
gs-4426	80	13	mechanism	mechanism	NOUN
gs-4426	80	14	defending	defend	VERB
gs-4426	80	15	against	against	ADP
gs-4426	80	16	viral	viral	ADJ
gs-4426	80	17	infection	infection	NOUN
gs-4426	80	18	,	,	PUNCT
gs-4426	80	19	utilizing	utilize	VERB
gs-4426	80	20	short	short	ADJ
gs-4426	80	21	rna	rna	NOUN
gs-4426	80	22	sequences	sequence	NOUN
gs-4426	80	23	to	to	PART
gs-4426	80	24	guide	guide	VERB
gs-4426	80	25	nuclease	nuclease	NOUN
gs-4426	80	26	-	-	PUNCT
gs-4426	80	27	mediated	mediate	VERB
gs-4426	80	28	destruction	destruction	NOUN
gs-4426	80	29	of	of	ADP
gs-4426	80	30	foreign	foreign	ADJ
gs-4426	80	31	genetic	genetic	ADJ
gs-4426	80	32	material	material	NOUN
gs-4426	80	33	.	.	PUNCT
gs-4426	81	1	the	the	DET
gs-4426	81	2	recognition	recognition	NOUN
gs-4426	81	3	that	that	SCONJ
gs-4426	81	4	this	this	DET
gs-4426	81	5	system	system	NOUN
gs-4426	81	6	could	could	AUX
gs-4426	81	7	be	be	AUX
gs-4426	81	8	reprogrammed	reprogramme	VERB
gs-4426	81	9	for	for	ADP
gs-4426	81	10	targeted	target	VERB
gs-4426	81	11	genome	genome	NOUN
gs-4426	81	12	editing	editing	NOUN
gs-4426	81	13	in	in	ADP
gs-4426	81	14	mammalian	mammalian	ADJ
gs-4426	81	15	cells	cell	NOUN
gs-4426	81	16	,	,	PUNCT
gs-4426	81	17	demonstrated	demonstrate	VERB
gs-4426	81	18	by	by	ADP
gs-4426	81	19	jennifer	jennifer	PROPN
gs-4426	81	20	doudna	doudna	PROPN
gs-4426	81	21	,	,	PUNCT
gs-4426	81	22	emmanuelle	emmanuelle	NOUN
gs-4426	81	23	charpentier	charpentier	NOUN
gs-4426	81	24	,	,	PUNCT
gs-4426	81	25	and	and	CCONJ
gs-4426	81	26	colleagues	colleague	NOUN
gs-4426	81	27	in	in	ADP
gs-4426	81	28	2012	2012	NUM
gs-4426	81	29	,	,	PUNCT
gs-4426	81	30	immediately	immediately	ADV
gs-4426	81	31	suggested	suggest	VERB
gs-4426	81	32	therapeutic	therapeutic	ADJ
gs-4426	81	33	applications	application	NOUN
gs-4426	81	34	(	(	PUNCT
gs-4426	81	35	davies	davy	NOUN
gs-4426	81	36	et	et	PROPN
gs-4426	81	37	al	al	PROPN
gs-4426	81	38	.	.	PROPN
gs-4426	81	39	,	,	PUNCT
gs-4426	81	40	2024	2024	NUM
gs-4426	81	41	)	)	PUNCT
gs-4426	81	42	.	.	PUNCT
gs-4426	82	1	the	the	DET
gs-4426	82	2	technology	technology	NOUN
gs-4426	82	3	's	's	PART
gs-4426	82	4	simplicity	simplicity	NOUN
gs-4426	82	5	relative	relative	ADJ
gs-4426	82	6	to	to	ADP
gs-4426	82	7	earlier	early	ADJ
gs-4426	82	8	genome	genome	NOUN
gs-4426	82	9	editing	editing	NOUN
gs-4426	82	10	platforms	platform	NOUN
gs-4426	82	11	,	,	PUNCT
gs-4426	82	12	requiring	require	VERB
gs-4426	82	13	only	only	ADV
gs-4426	82	14	a	a	DET
gs-4426	82	15	guide	guide	NOUN
gs-4426	82	16	rna	rna	NOUN
gs-4426	82	17	and	and	CCONJ
gs-4426	82	18	cas9	cas9	NOUN
gs-4426	82	19	protein	protein	NOUN
gs-4426	82	20	rather	rather	ADV
gs-4426	82	21	than	than	ADP
gs-4426	82	22	engineering	engineering	NOUN
gs-4426	82	23	of	of	ADP
gs-4426	82	24	sequence	sequence	NOUN
gs-4426	82	25	-	-	PUNCT
gs-4426	82	26	specific	specific	ADJ
gs-4426	82	27	dna	dna	NOUN
gs-4426	82	28	-	-	PUNCT
gs-4426	82	29	binding	bind	VERB
gs-4426	82	30	proteins	protein	NOUN
gs-4426	82	31	,	,	PUNCT
gs-4426	82	32	enabled	enable	VERB
gs-4426	82	33	rapid	rapid	ADJ
gs-4426	82	34	adoption	adoption	NOUN
gs-4426	82	35	across	across	ADP
gs-4426	82	36	research	research	NOUN
gs-4426	82	37	laboratories	laboratory	NOUN
gs-4426	82	38	worldwide	worldwide	ADV
gs-4426	82	39	and	and	CCONJ
gs-4426	82	40	accelerated	accelerate	VERB
gs-4426	82	41	preclinical	preclinical	ADJ
gs-4426	82	42	development	development	NOUN
gs-4426	82	43	of	of	ADP
gs-4426	82	44	therapeutic	therapeutic	ADJ
gs-4426	82	45	applications	application	NOUN
gs-4426	82	46	.	.	PUNCT
gs-4426	83	1	the	the	DET
gs-4426	83	2	initial	initial	ADJ
gs-4426	83	3	wave	wave	NOUN
gs-4426	83	4	of	of	ADP
gs-4426	83	5	crispr	crispr	ADJ
gs-4426	83	6	clinical	clinical	ADJ
gs-4426	83	7	trials	trial	NOUN
gs-4426	83	8	,	,	PUNCT
gs-4426	83	9	beginning	begin	VERB
gs-4426	83	10	in	in	ADP
gs-4426	83	11	2016	2016	NUM
gs-4426	83	12	,	,	PUNCT
gs-4426	83	13	focused	focus	VERB
gs-4426	83	14	on	on	ADP
gs-4426	83	15	ex	ex	PRON
gs-4426	83	16	vivo	vivo	NOUN
gs-4426	83	17	editing	editing	NOUN
gs-4426	83	18	of	of	ADP
gs-4426	83	19	t	t	NOUN
gs-4426	83	20	cells	cell	NOUN
gs-4426	83	21	and	and	CCONJ
gs-4426	83	22	hematopoietic	hematopoietic	ADJ
gs-4426	83	23	stem	stem	NOUN
gs-4426	83	24	cells	cell	NOUN
gs-4426	83	25	to	to	PART
gs-4426	83	26	avoid	avoid	VERB
gs-4426	83	27	potential	potential	ADJ
gs-4426	83	28	safety	safety	NOUN
gs-4426	83	29	concerns	concern	NOUN
gs-4426	83	30	associated	associate	VERB
gs-4426	83	31	with	with	ADP
gs-4426	83	32	in	in	ADP
gs-4426	83	33	vivo	vivo	ADJ
gs-4426	83	34	editing	editing	NOUN
gs-4426	83	35	.	.	PUNCT
gs-4426	84	1	these	these	DET
gs-4426	84	2	trials	trial	NOUN
gs-4426	84	3	targeted	target	VERB
gs-4426	84	4	cancer	cancer	NOUN
gs-4426	84	5	through	through	ADP
gs-4426	84	6	disruption	disruption	NOUN
gs-4426	84	7	of	of	ADP
gs-4426	84	8	immune	immune	ADJ
gs-4426	84	9	checkpoint	checkpoint	NOUN
gs-4426	84	10	genes	gene	NOUN
gs-4426	84	11	in	in	ADP
gs-4426	84	12	autologous	autologous	ADJ
gs-4426	84	13	t	t	NOUN
gs-4426	84	14	cells	cell	NOUN
gs-4426	84	15	,	,	PUNCT
gs-4426	84	16	georgian	georgian	NOUN
gs-4426	84	17	scientists/	scientists/	NUM
gs-4426	84	18	.	.	PUNCT
gs-4426	85	1	7	7	NUM
gs-4426	85	2	n	n	DET
gs-4426	85	3	4	4	NUM
gs-4426	85	4	,	,	PUNCT
gs-4426	85	5	2025	2025	NUM
gs-4426	85	6	598	598	NUM
gs-4426	85	7	enhancement	enhancement	NOUN
gs-4426	85	8	of	of	ADP
gs-4426	85	9	t	t	NOUN
gs-4426	85	10	-	-	PUNCT
gs-4426	85	11	cell	cell	NOUN
gs-4426	85	12	receptor	receptor	NOUN
gs-4426	85	13	specificity	specificity	NOUN
gs-4426	85	14	,	,	PUNCT
gs-4426	85	15	and	and	CCONJ
gs-4426	85	16	engineering	engineering	NOUN
gs-4426	85	17	of	of	ADP
gs-4426	85	18	universal	universal	ADJ
gs-4426	85	19	donor	donor	NOUN
gs-4426	85	20	car	car	NOUN
gs-4426	85	21	-	-	PUNCT
gs-4426	85	22	t	t	NOUN
gs-4426	85	23	cells	cell	NOUN
gs-4426	85	24	through	through	ADP
gs-4426	85	25	elimination	elimination	NOUN
gs-4426	85	26	of	of	ADP
gs-4426	85	27	endogenous	endogenous	ADJ
gs-4426	85	28	t	t	NOUN
gs-4426	85	29	-	-	PUNCT
gs-4426	85	30	cell	cell	NOUN
gs-4426	85	31	receptors	receptor	NOUN
gs-4426	85	32	and	and	CCONJ
gs-4426	85	33	hla	hla	NOUN
gs-4426	85	34	molecules	molecule	NOUN
gs-4426	85	35	.	.	PUNCT
gs-4426	86	1	parallel	parallel	ADJ
gs-4426	86	2	efforts	effort	NOUN
gs-4426	86	3	addressed	address	VERB
gs-4426	86	4	monogenic	monogenic	ADJ
gs-4426	86	5	blood	blood	NOUN
gs-4426	86	6	disorders	disorder	NOUN
gs-4426	86	7	including	include	VERB
gs-4426	86	8	sickle	sickle	NOUN
gs-4426	86	9	cell	cell	NOUN
gs-4426	86	10	disease	disease	NOUN
gs-4426	86	11	and	and	CCONJ
gs-4426	86	12	beta	beta	NOUN
gs-4426	86	13	thalassemia	thalassemia	NOUN
gs-4426	86	14	through	through	ADP
gs-4426	86	15	editing	editing	NOUN
gs-4426	86	16	of	of	ADP
gs-4426	86	17	hematopoietic	hematopoietic	ADJ
gs-4426	86	18	stem	stem	NOUN
gs-4426	86	19	cells	cell	NOUN
gs-4426	86	20	.	.	PUNCT
gs-4426	87	1	the	the	DET
gs-4426	87	2	ex	ex	X
gs-4426	87	3	vivo	vivo	NOUN
gs-4426	87	4	approach	approach	NOUN
gs-4426	87	5	provided	provide	VERB
gs-4426	87	6	several	several	ADJ
gs-4426	87	7	safety	safety	NOUN
gs-4426	87	8	advantages	advantage	NOUN
gs-4426	87	9	including	include	VERB
gs-4426	87	10	the	the	DET
gs-4426	87	11	ability	ability	NOUN
gs-4426	87	12	to	to	PART
gs-4426	87	13	characterize	characterize	VERB
gs-4426	87	14	edited	edit	VERB
gs-4426	87	15	cell	cell	NOUN
gs-4426	87	16	products	product	NOUN
gs-4426	87	17	extensively	extensively	ADV
gs-4426	87	18	before	before	ADP
gs-4426	87	19	administration	administration	NOUN
gs-4426	87	20	,	,	PUNCT
gs-4426	87	21	selection	selection	NOUN
gs-4426	87	22	of	of	ADP
gs-4426	87	23	properly	properly	ADV
gs-4426	87	24	edited	edit	VERB
gs-4426	87	25	cells	cell	NOUN
gs-4426	87	26	while	while	SCONJ
gs-4426	87	27	eliminating	eliminate	VERB
gs-4426	87	28	undesired	undesired	ADJ
gs-4426	87	29	populations	population	NOUN
gs-4426	87	30	,	,	PUNCT
gs-4426	87	31	and	and	CCONJ
gs-4426	87	32	avoidance	avoidance	NOUN
gs-4426	87	33	of	of	ADP
gs-4426	87	34	immune	immune	ADJ
gs-4426	87	35	responses	response	NOUN
gs-4426	87	36	to	to	ADP
gs-4426	87	37	crispr	crispr	ADJ
gs-4426	87	38	components	component	NOUN
gs-4426	87	39	that	that	PRON
gs-4426	87	40	might	might	AUX
gs-4426	87	41	occur	occur	VERB
gs-4426	87	42	with	with	ADP
gs-4426	87	43	in	in	ADP
gs-4426	87	44	vivo	vivo	ADJ
gs-4426	87	45	delivery	delivery	NOUN
gs-4426	87	46	.	.	PUNCT
gs-4426	88	1	the	the	DET
gs-4426	88	2	development	development	NOUN
gs-4426	88	3	of	of	ADP
gs-4426	88	4	casgevy	casgevy	NOUN
gs-4426	88	5	for	for	ADP
gs-4426	88	6	sickle	sickle	NOUN
gs-4426	88	7	cell	cell	NOUN
gs-4426	88	8	disease	disease	NOUN
gs-4426	88	9	and	and	CCONJ
gs-4426	88	10	beta	beta	NOUN
gs-4426	88	11	thalassemia	thalassemia	NOUN
gs-4426	88	12	exemplifies	exemplify	VERB
gs-4426	88	13	the	the	DET
gs-4426	88	14	therapeutic	therapeutic	ADJ
gs-4426	88	15	potential	potential	ADJ
gs-4426	88	16	and	and	CCONJ
gs-4426	88	17	translational	translational	ADJ
gs-4426	88	18	pathway	pathway	NOUN
gs-4426	88	19	for	for	ADP
gs-4426	88	20	crispr	crispr	NOUN
gs-4426	88	21	-	-	PUNCT
gs-4426	88	22	based	base	VERB
gs-4426	88	23	medicines	medicine	NOUN
gs-4426	88	24	.	.	PUNCT
gs-4426	89	1	the	the	DET
gs-4426	89	2	therapy	therapy	NOUN
gs-4426	89	3	employs	employ	VERB
gs-4426	89	4	ex	ex	PRON
gs-4426	89	5	vivo	vivo	ADJ
gs-4426	89	6	crispr	crispr	ADJ
gs-4426	89	7	-	-	PUNCT
gs-4426	89	8	cas9	cas9	NOUN
gs-4426	89	9	editing	editing	NOUN
gs-4426	89	10	of	of	ADP
gs-4426	89	11	autologous	autologous	ADJ
gs-4426	89	12	cd34	cd34	PROPN
gs-4426	89	13	-	-	PUNCT
gs-4426	89	14	positive	positive	ADJ
gs-4426	89	15	hematopoietic	hematopoietic	ADJ
gs-4426	89	16	stem	stem	NOUN
gs-4426	89	17	and	and	CCONJ
gs-4426	89	18	progenitor	progenitor	NOUN
gs-4426	89	19	cells	cell	NOUN
gs-4426	89	20	to	to	PART
gs-4426	89	21	disrupt	disrupt	VERB
gs-4426	89	22	the	the	DET
gs-4426	89	23	bcl11a	bcl11a	X
gs-4426	89	24	erythroid	erythroid	ADJ
gs-4426	89	25	-	-	PUNCT
gs-4426	89	26	specific	specific	ADJ
gs-4426	89	27	enhancer	enhancer	NOUN
gs-4426	89	28	,	,	PUNCT
gs-4426	89	29	leading	lead	VERB
gs-4426	89	30	to	to	ADP
gs-4426	89	31	reactivation	reactivation	NOUN
gs-4426	89	32	of	of	ADP
gs-4426	89	33	fetal	fetal	ADJ
gs-4426	89	34	hemoglobin	hemoglobin	NOUN
gs-4426	89	35	production	production	NOUN
gs-4426	89	36	.	.	PUNCT
gs-4426	90	1	elevated	elevated	ADJ
gs-4426	90	2	fetal	fetal	ADJ
gs-4426	90	3	hemoglobin	hemoglobin	NOUN
gs-4426	90	4	levels	level	NOUN
gs-4426	90	5	ameliorate	ameliorate	VERB
gs-4426	90	6	disease	disease	NOUN
gs-4426	90	7	manifestations	manifestation	NOUN
gs-4426	90	8	in	in	ADP
gs-4426	90	9	both	both	DET
gs-4426	90	10	conditions	condition	NOUN
gs-4426	90	11	by	by	ADP
gs-4426	90	12	inhibiting	inhibit	VERB
gs-4426	90	13	sickle	sickle	NOUN
gs-4426	90	14	hemoglobin	hemoglobin	NOUN
gs-4426	90	15	polymerization	polymerization	NOUN
gs-4426	90	16	and	and	CCONJ
gs-4426	90	17	compensating	compensate	VERB
gs-4426	90	18	for	for	ADP
gs-4426	90	19	deficient	deficient	ADJ
gs-4426	90	20	adult	adult	NOUN
gs-4426	90	21	hemoglobin	hemoglobin	NOUN
gs-4426	90	22	.	.	PUNCT
gs-4426	91	1	clinical	clinical	ADJ
gs-4426	91	2	trials	trial	NOUN
gs-4426	91	3	demonstrated	demonstrate	VERB
gs-4426	91	4	that	that	SCONJ
gs-4426	91	5	single	single	ADJ
gs-4426	91	6	-	-	PUNCT
gs-4426	91	7	administration	administration	NOUN
gs-4426	91	8	casgevy	casgevy	NOUN
gs-4426	91	9	treatment	treatment	NOUN
gs-4426	91	10	produced	produce	VERB
gs-4426	91	11	sustained	sustain	VERB
gs-4426	91	12	clinical	clinical	ADJ
gs-4426	91	13	benefits	benefit	NOUN
gs-4426	91	14	including	include	VERB
gs-4426	91	15	elimination	elimination	NOUN
gs-4426	91	16	of	of	ADP
gs-4426	91	17	vaso	vaso	NOUN
gs-4426	91	18	-	-	PUNCT
gs-4426	91	19	occlusive	occlusive	ADJ
gs-4426	91	20	crises	crisis	NOUN
gs-4426	91	21	in	in	ADP
gs-4426	91	22	sickle	sickle	NOUN
gs-4426	91	23	cell	cell	NOUN
gs-4426	91	24	disease	disease	NOUN
gs-4426	91	25	patients	patient	NOUN
gs-4426	91	26	and	and	CCONJ
gs-4426	91	27	transfusion	transfusion	NOUN
gs-4426	91	28	independence	independence	NOUN
gs-4426	91	29	in	in	ADP
gs-4426	91	30	beta	beta	NOUN
gs-4426	91	31	thalassemia	thalassemia	NOUN
gs-4426	91	32	patients	patient	NOUN
gs-4426	91	33	,	,	PUNCT
gs-4426	91	34	with	with	ADP
gs-4426	91	35	benefits	benefit	NOUN
gs-4426	91	36	maintained	maintain	VERB
gs-4426	91	37	over	over	ADP
gs-4426	91	38	multi	multi	ADJ
gs-4426	91	39	-	-	ADJ
gs-4426	91	40	year	year	ADJ
gs-4426	91	41	follow	follow	NOUN
gs-4426	91	42	-	-	PUNCT
gs-4426	91	43	up	up	NOUN
gs-4426	91	44	.	.	PUNCT
gs-4426	92	1	the	the	DET
gs-4426	92	2	fda	fda	PROPN
gs-4426	92	3	approval	approval	NOUN
gs-4426	92	4	of	of	ADP
gs-4426	92	5	casgevy	casgevy	NOUN
gs-4426	92	6	in	in	ADP
gs-4426	92	7	december	december	PROPN
gs-4426	92	8	2023	2023	NUM
gs-4426	92	9	,	,	PUNCT
gs-4426	92	10	followed	follow	VERB
gs-4426	92	11	by	by	ADP
gs-4426	92	12	regulatory	regulatory	ADJ
gs-4426	92	13	approvals	approval	NOUN
gs-4426	92	14	in	in	ADP
gs-4426	92	15	the	the	DET
gs-4426	92	16	united	united	PROPN
gs-4426	92	17	kingdom	kingdom	PROPN
gs-4426	92	18	and	and	CCONJ
gs-4426	92	19	european	european	PROPN
gs-4426	92	20	union	union	PROPN
gs-4426	92	21	,	,	PUNCT
gs-4426	92	22	validated	validate	VERB
gs-4426	92	23	crispr	crispr	ADJ
gs-4426	92	24	editing	editing	NOUN
gs-4426	92	25	as	as	ADP
gs-4426	92	26	a	a	DET
gs-4426	92	27	clinically	clinically	ADV
gs-4426	92	28	viable	viable	ADJ
gs-4426	92	29	therapeutic	therapeutic	ADJ
gs-4426	92	30	approach	approach	NOUN
gs-4426	92	31	and	and	CCONJ
gs-4426	92	32	established	establish	VERB
gs-4426	92	33	regulatory	regulatory	ADJ
gs-4426	92	34	precedents	precedent	NOUN
gs-4426	92	35	for	for	ADP
gs-4426	92	36	genome	genome	NOUN
gs-4426	92	37	editing	editing	NOUN
gs-4426	92	38	therapies	therapy	NOUN
gs-4426	92	39	.	.	PUNCT
gs-4426	93	1	beyond	beyond	ADP
gs-4426	93	2	ex	ex	PRON
gs-4426	93	3	vivo	vivo	NOUN
gs-4426	93	4	applications	application	NOUN
gs-4426	93	5	,	,	PUNCT
gs-4426	93	6	crispr	crispr	ADJ
gs-4426	93	7	technology	technology	NOUN
gs-4426	93	8	is	be	AUX
gs-4426	93	9	advancing	advance	VERB
gs-4426	93	10	toward	toward	ADP
gs-4426	93	11	in	in	ADP
gs-4426	93	12	vivo	vivo	ADJ
gs-4426	93	13	genome	genome	NOUN
gs-4426	93	14	editing	editing	NOUN
gs-4426	93	15	that	that	PRON
gs-4426	93	16	would	would	AUX
gs-4426	93	17	enable	enable	VERB
gs-4426	93	18	treatment	treatment	NOUN
gs-4426	93	19	of	of	ADP
gs-4426	93	20	diseases	disease	NOUN
gs-4426	93	21	affecting	affect	VERB
gs-4426	93	22	tissues	tissue	NOUN
gs-4426	93	23	inaccessible	inaccessible	ADJ
gs-4426	93	24	to	to	ADP
gs-4426	93	25	ex	ex	PRON
gs-4426	93	26	vivo	vivo	ADJ
gs-4426	93	27	manipulation	manipulation	NOUN
gs-4426	93	28	.	.	PUNCT
gs-4426	94	1	early	early	ADV
gs-4426	94	2	in	in	ADP
gs-4426	94	3	vivo	vivo	ADJ
gs-4426	94	4	crispr	crispr	ADJ
gs-4426	94	5	trials	trial	NOUN
gs-4426	94	6	have	have	AUX
gs-4426	94	7	targeted	target	VERB
gs-4426	94	8	the	the	DET
gs-4426	94	9	liver	liver	NOUN
gs-4426	94	10	through	through	ADP
gs-4426	94	11	intravenous	intravenous	ADJ
gs-4426	94	12	delivery	delivery	NOUN
gs-4426	94	13	of	of	ADP
gs-4426	94	14	lipid	lipid	ADJ
gs-4426	94	15	nanoparticles	nanoparticle	NOUN
gs-4426	94	16	encapsulating	encapsulate	VERB
gs-4426	94	17	cas9	cas9	PROPN
gs-4426	94	18	mrna	mrna	PROPN
gs-4426	94	19	and	and	CCONJ
gs-4426	94	20	guide	guide	VERB
gs-4426	94	21	rnas	rna	NOUN
gs-4426	94	22	,	,	PUNCT
gs-4426	94	23	taking	take	VERB
gs-4426	94	24	advantage	advantage	NOUN
gs-4426	94	25	of	of	ADP
gs-4426	94	26	the	the	DET
gs-4426	94	27	liver	liver	NOUN
gs-4426	94	28	's	's	PART
gs-4426	94	29	natural	natural	ADJ
gs-4426	94	30	propensity	propensity	NOUN
gs-4426	94	31	for	for	ADP
gs-4426	94	32	uptake	uptake	NOUN
gs-4426	94	33	of	of	ADP
gs-4426	94	34	lipid	lipid	ADJ
gs-4426	94	35	particles	particle	NOUN
gs-4426	94	36	and	and	CCONJ
gs-4426	94	37	its	its	PRON
gs-4426	94	38	immunologically	immunologically	ADV
gs-4426	94	39	privileged	privileged	ADJ
gs-4426	94	40	environment	environment	NOUN
gs-4426	94	41	.	.	PUNCT
gs-4426	95	1	clinical	clinical	ADJ
gs-4426	95	2	trials	trial	NOUN
gs-4426	95	3	evaluating	evaluate	VERB
gs-4426	95	4	crispr	crispr	NOUN
gs-4426	95	5	-	-	PUNCT
gs-4426	95	6	mediated	mediate	VERB
gs-4426	95	7	disruption	disruption	NOUN
gs-4426	95	8	of	of	ADP
gs-4426	95	9	pcsk9	pcsk9	NOUN
gs-4426	95	10	for	for	ADP
gs-4426	95	11	hypercholesterolemia	hypercholesterolemia	NOUN
gs-4426	95	12	,	,	PUNCT
gs-4426	95	13	ttr	ttr	VERB
gs-4426	95	14	for	for	ADP
gs-4426	95	15	transthyretin	transthyretin	NOUN
gs-4426	95	16	amyloidosis	amyloidosis	NOUN
gs-4426	95	17	,	,	PUNCT
gs-4426	95	18	and	and	CCONJ
gs-4426	95	19	other	other	ADJ
gs-4426	95	20	hepatic	hepatic	ADJ
gs-4426	95	21	genes	gene	NOUN
gs-4426	95	22	have	have	AUX
gs-4426	95	23	demonstrated	demonstrate	VERB
gs-4426	95	24	proof	proof	NOUN
gs-4426	95	25	-	-	PUNCT
gs-4426	95	26	of	of	ADP
gs-4426	95	27	-	-	PUNCT
gs-4426	95	28	concept	concept	NOUN
gs-4426	95	29	efficacy	efficacy	NOUN
gs-4426	95	30	with	with	ADP
gs-4426	95	31	acceptable	acceptable	ADJ
gs-4426	95	32	safety	safety	NOUN
gs-4426	95	33	profiles	profile	NOUN
gs-4426	95	34	in	in	ADP
gs-4426	95	35	early	early	ADJ
gs-4426	95	36	results	result	NOUN
gs-4426	95	37	.	.	PUNCT
gs-4426	96	1	the	the	DET
gs-4426	96	2	development	development	NOUN
gs-4426	96	3	of	of	ADP
gs-4426	96	4	tissue	tissue	NOUN
gs-4426	96	5	-	-	PUNCT
gs-4426	96	6	specific	specific	ADJ
gs-4426	96	7	delivery	delivery	NOUN
gs-4426	96	8	systems	system	NOUN
gs-4426	96	9	,	,	PUNCT
gs-4426	96	10	including	include	VERB
gs-4426	96	11	engineered	engineer	VERB
gs-4426	96	12	aav	aav	NOUN
gs-4426	96	13	capsids	capsid	NOUN
gs-4426	96	14	and	and	CCONJ
gs-4426	96	15	synthetic	synthetic	ADJ
gs-4426	96	16	nanoparticles	nanoparticle	NOUN
gs-4426	96	17	with	with	ADP
gs-4426	96	18	targeting	target	VERB
gs-4426	96	19	ligands	ligand	NOUN
gs-4426	96	20	,	,	PUNCT
gs-4426	96	21	aims	aim	VERB
gs-4426	96	22	to	to	PART
gs-4426	96	23	expand	expand	VERB
gs-4426	96	24	in	in	ADP
gs-4426	96	25	vivo	vivo	NOUN
gs-4426	96	26	editing	edit	VERB
gs-4426	96	27	to	to	ADP
gs-4426	96	28	additional	additional	ADJ
gs-4426	96	29	organs	organ	NOUN
gs-4426	96	30	.	.	PUNCT
gs-4426	97	1	advanced	advanced	ADJ
gs-4426	97	2	crispr	crispr	ADJ
gs-4426	97	3	variants	variant	NOUN
gs-4426	97	4	including	include	VERB
gs-4426	97	5	base	base	NOUN
gs-4426	97	6	editors	editor	NOUN
gs-4426	97	7	that	that	PRON
gs-4426	97	8	convert	convert	VERB
gs-4426	97	9	individual	individual	ADJ
gs-4426	97	10	nucleotides	nucleotide	NOUN
gs-4426	97	11	without	without	ADP
gs-4426	97	12	creating	create	VERB
gs-4426	97	13	double	double	ADJ
gs-4426	97	14	-	-	PUNCT
gs-4426	97	15	strand	strand	NOUN
gs-4426	97	16	breaks	break	NOUN
gs-4426	97	17	and	and	CCONJ
gs-4426	97	18	prime	prime	ADJ
gs-4426	97	19	editors	editor	NOUN
gs-4426	97	20	that	that	PRON
gs-4426	97	21	enable	enable	VERB
gs-4426	97	22	insertion	insertion	NOUN
gs-4426	97	23	,	,	PUNCT
gs-4426	97	24	deletion	deletion	NOUN
gs-4426	97	25	,	,	PUNCT
gs-4426	97	26	or	or	CCONJ
gs-4426	97	27	replacement	replacement	NOUN
gs-4426	97	28	of	of	ADP
gs-4426	97	29	dna	dna	PROPN
gs-4426	97	30	sequences	sequence	NOUN
gs-4426	97	31	without	without	ADP
gs-4426	97	32	requiring	require	VERB
gs-4426	97	33	double	double	ADJ
gs-4426	97	34	-	-	PUNCT
gs-4426	97	35	strand	strand	NOUN
gs-4426	97	36	breaks	break	NOUN
gs-4426	97	37	or	or	CCONJ
gs-4426	97	38	donor	donor	NOUN
gs-4426	97	39	templates	template	NOUN
gs-4426	97	40	promise	promise	VERB
gs-4426	97	41	to	to	PART
gs-4426	97	42	enhance	enhance	VERB
gs-4426	97	43	editing	edit	VERB
gs-4426	97	44	precision	precision	NOUN
gs-4426	97	45	and	and	CCONJ
gs-4426	97	46	expand	expand	VERB
gs-4426	97	47	the	the	DET
gs-4426	97	48	range	range	NOUN
gs-4426	97	49	of	of	ADP
gs-4426	97	50	correctable	correctable	ADJ
gs-4426	97	51	mutations	mutation	NOUN
gs-4426	97	52	.	.	PUNCT
gs-4426	98	1	car	car	NOUN
gs-4426	98	2	-	-	PUNCT
gs-4426	98	3	t	t	PROPN
gs-4426	98	4	cell	cell	NOUN
gs-4426	98	5	therapy	therapy	NOUN
gs-4426	98	6	:	:	PUNCT
gs-4426	98	7	transforming	transform	VERB
gs-4426	98	8	cancer	cancer	NOUN
gs-4426	98	9	treatment	treatment	NOUN
gs-4426	98	10	chimeric	chimeric	ADJ
gs-4426	98	11	antigen	antigen	ADJ
gs-4426	98	12	receptor	receptor	NOUN
gs-4426	98	13	t	t	NOUN
gs-4426	98	14	-	-	PUNCT
gs-4426	98	15	cell	cell	NOUN
gs-4426	98	16	therapy	therapy	NOUN
gs-4426	98	17	represents	represent	VERB
gs-4426	98	18	one	one	NUM
gs-4426	98	19	of	of	ADP
gs-4426	98	20	gene	gene	NOUN
gs-4426	98	21	therapy	therapy	NOUN
gs-4426	98	22	's	's	PART
gs-4426	98	23	most	most	ADV
gs-4426	98	24	significant	significant	ADJ
gs-4426	98	25	clinical	clinical	ADJ
gs-4426	98	26	success	success	NOUN
gs-4426	98	27	stories	story	NOUN
gs-4426	98	28	,	,	PUNCT
gs-4426	98	29	achieving	achieve	VERB
gs-4426	98	30	unprecedented	unprecedented	ADJ
gs-4426	98	31	response	response	NOUN
gs-4426	98	32	rates	rate	NOUN
gs-4426	98	33	in	in	ADP
gs-4426	98	34	previously	previously	ADV
gs-4426	98	35	incurable	incurable	ADJ
gs-4426	98	36	hematological	hematological	ADJ
gs-4426	98	37	malignancies	malignancy	NOUN
gs-4426	98	38	.	.	PUNCT
gs-4426	99	1	the	the	DET
gs-4426	99	2	conceptual	conceptual	ADJ
gs-4426	99	3	foundation	foundation	NOUN
gs-4426	99	4	for	for	ADP
gs-4426	99	5	car	car	NOUN
gs-4426	99	6	-	-	PUNCT
gs-4426	99	7	t	t	NOUN
gs-4426	99	8	therapy	therapy	NOUN
gs-4426	99	9	emerged	emerge	VERB
gs-4426	99	10	in	in	ADP
gs-4426	99	11	the	the	DET
gs-4426	99	12	late	late	ADJ
gs-4426	99	13	1980s	1980	NOUN
gs-4426	99	14	when	when	SCONJ
gs-4426	99	15	researchers	researcher	NOUN
gs-4426	99	16	demonstrated	demonstrate	VERB
gs-4426	99	17	that	that	SCONJ
gs-4426	99	18	t	t	NOUN
gs-4426	99	19	cells	cell	NOUN
gs-4426	99	20	could	could	AUX
gs-4426	99	21	be	be	AUX
gs-4426	99	22	redirected	redirect	VERB
gs-4426	99	23	toward	toward	ADP
gs-4426	99	24	tumor	tumor	NOUN
gs-4426	99	25	antigens	antigen	NOUN
gs-4426	99	26	through	through	ADP
gs-4426	99	27	expression	expression	NOUN
gs-4426	99	28	of	of	ADP
gs-4426	99	29	synthetic	synthetic	ADJ
gs-4426	99	30	receptors	receptor	NOUN
gs-4426	99	31	combining	combine	VERB
gs-4426	99	32	antibody	antibody	NOUN
gs-4426	99	33	-	-	PUNCT
gs-4426	99	34	derived	derive	VERB
gs-4426	99	35	antigen	antigen	NOUN
gs-4426	99	36	recognition	recognition	NOUN
gs-4426	99	37	domains	domain	NOUN
gs-4426	99	38	with	with	ADP
gs-4426	99	39	t	t	NOUN
gs-4426	99	40	-	-	PUNCT
gs-4426	99	41	cell	cell	NOUN
gs-4426	99	42	activation	activation	NOUN
gs-4426	99	43	signaling	signal	VERB
gs-4426	99	44	domains	domain	NOUN
gs-4426	99	45	.	.	PUNCT
gs-4426	100	1	early	early	ADJ
gs-4426	100	2	car	car	NOUN
gs-4426	100	3	designs	design	NOUN
gs-4426	100	4	incorporating	incorporate	VERB
gs-4426	100	5	only	only	ADV
gs-4426	100	6	cd3	cd3	VERB
gs-4426	100	7	-	-	PUNCT
gs-4426	100	8	zeta	zeta	NOUN
gs-4426	100	9	signaling	signal	VERB
gs-4426	100	10	domains	domain	NOUN
gs-4426	100	11	demonstrated	demonstrate	VERB
gs-4426	100	12	limited	limited	ADJ
gs-4426	100	13	persistence	persistence	NOUN
gs-4426	100	14	and	and	CCONJ
gs-4426	100	15	efficacy	efficacy	NOUN
gs-4426	100	16	,	,	PUNCT
gs-4426	100	17	but	but	CCONJ
gs-4426	100	18	second	second	ADJ
gs-4426	100	19	-	-	PUNCT
gs-4426	100	20	generation	generation	NOUN
gs-4426	100	21	cars	car	NOUN
gs-4426	100	22	incorporating	incorporate	VERB
gs-4426	100	23	georgian	georgian	PROPN
gs-4426	100	24	scientists/	scientists/	NUM
gs-4426	100	25	.	.	PUNCT
gs-4426	101	1	7	7	NUM
gs-4426	101	2	n	n	DET
gs-4426	101	3	4	4	NUM
gs-4426	101	4	,	,	PUNCT
gs-4426	101	5	2025	2025	NUM
gs-4426	101	6	599	599	NUM
gs-4426	101	7	costimulatory	costimulatory	NOUN
gs-4426	101	8	domains	domain	NOUN
gs-4426	101	9	from	from	ADP
gs-4426	101	10	cd28	cd28	PROPN
gs-4426	101	11	or	or	CCONJ
gs-4426	101	12	4	4	NUM
gs-4426	101	13	-	-	PUNCT
gs-4426	101	14	1bb	1bb	NOUN
gs-4426	101	15	achieved	achieve	VERB
gs-4426	101	16	substantially	substantially	ADV
gs-4426	101	17	improved	improve	VERB
gs-4426	101	18	t	t	NOUN
gs-4426	101	19	-	-	PUNCT
gs-4426	101	20	cell	cell	NOUN
gs-4426	101	21	expansion	expansion	NOUN
gs-4426	101	22	,	,	PUNCT
gs-4426	101	23	persistence	persistence	NOUN
gs-4426	101	24	,	,	PUNCT
gs-4426	101	25	and	and	CCONJ
gs-4426	101	26	anti	anti	ADJ
gs-4426	101	27	-	-	ADJ
gs-4426	101	28	tumor	tumor	ADJ
gs-4426	101	29	activity	activity	NOUN
gs-4426	101	30	(	(	PUNCT
gs-4426	101	31	han	han	PROPN
gs-4426	101	32	et	et	PROPN
gs-4426	101	33	al	al	PROPN
gs-4426	101	34	.	.	PROPN
gs-4426	101	35	,	,	PUNCT
gs-4426	101	36	2021	2021	NUM
gs-4426	101	37	)	)	PUNCT
gs-4426	101	38	.	.	PUNCT
gs-4426	102	1	the	the	DET
gs-4426	102	2	selection	selection	NOUN
gs-4426	102	3	of	of	ADP
gs-4426	102	4	cd19	cd19	PROPN
gs-4426	102	5	,	,	PUNCT
gs-4426	102	6	a	a	DET
gs-4426	102	7	b	b	NOUN
gs-4426	102	8	-	-	PUNCT
gs-4426	102	9	cell	cell	NOUN
gs-4426	102	10	lineage	lineage	NOUN
gs-4426	102	11	marker	marker	NOUN
gs-4426	102	12	expressed	express	VERB
gs-4426	102	13	on	on	ADP
gs-4426	102	14	most	most	ADJ
gs-4426	102	15	b	b	NOUN
gs-4426	102	16	-	-	PUNCT
gs-4426	102	17	cell	cell	NOUN
gs-4426	102	18	malignancies	malignancy	NOUN
gs-4426	102	19	but	but	CCONJ
gs-4426	102	20	not	not	PART
gs-4426	102	21	required	require	VERB
gs-4426	102	22	for	for	ADP
gs-4426	102	23	survival	survival	NOUN
gs-4426	102	24	of	of	ADP
gs-4426	102	25	plasma	plasma	NOUN
gs-4426	102	26	cells	cell	NOUN
gs-4426	102	27	or	or	CCONJ
gs-4426	102	28	hematopoietic	hematopoietic	ADJ
gs-4426	102	29	stem	stem	NOUN
gs-4426	102	30	cells	cell	NOUN
gs-4426	102	31	,	,	PUNCT
gs-4426	102	32	as	as	SCONJ
gs-4426	102	33	the	the	DET
gs-4426	102	34	initial	initial	ADJ
gs-4426	102	35	therapeutic	therapeutic	ADJ
gs-4426	102	36	target	target	NOUN
gs-4426	102	37	proved	prove	VERB
gs-4426	102	38	crucial	crucial	ADJ
gs-4426	102	39	for	for	ADP
gs-4426	102	40	demonstrating	demonstrate	VERB
gs-4426	102	41	clinical	clinical	ADJ
gs-4426	102	42	proof	proof	NOUN
gs-4426	102	43	-	-	PUNCT
gs-4426	102	44	of	of	ADP
gs-4426	102	45	-	-	PUNCT
gs-4426	102	46	concept	concept	NOUN
gs-4426	102	47	while	while	SCONJ
gs-4426	102	48	maintaining	maintain	VERB
gs-4426	102	49	acceptable	acceptable	ADJ
gs-4426	102	50	safety	safety	NOUN
gs-4426	102	51	through	through	ADP
gs-4426	102	52	transient	transient	ADJ
gs-4426	102	53	b	b	X
gs-4426	102	54	-	-	PUNCT
gs-4426	102	55	cell	cell	NOUN
gs-4426	102	56	depletion	depletion	NOUN
gs-4426	102	57	manageable	manageable	ADJ
gs-4426	102	58	with	with	ADP
gs-4426	102	59	immunoglobulin	immunoglobulin	NOUN
gs-4426	102	60	replacement	replacement	NOUN
gs-4426	102	61	.	.	PUNCT
gs-4426	103	1	the	the	DET
gs-4426	103	2	pivotal	pivotal	ADJ
gs-4426	103	3	clinical	clinical	ADJ
gs-4426	103	4	trials	trial	NOUN
gs-4426	103	5	of	of	ADP
gs-4426	103	6	cd19	cd19	PROPN
gs-4426	103	7	-	-	PUNCT
gs-4426	103	8	directed	direct	VERB
gs-4426	103	9	car	car	NOUN
gs-4426	103	10	-	-	PUNCT
gs-4426	103	11	t	t	NOUN
gs-4426	103	12	cells	cell	NOUN
gs-4426	103	13	in	in	ADP
gs-4426	103	14	relapsed	relapse	VERB
gs-4426	103	15	/	/	SYM
gs-4426	103	16	refractory	refractory	NOUN
gs-4426	103	17	acute	acute	NOUN
gs-4426	103	18	lymphoblastic	lymphoblastic	ADJ
gs-4426	103	19	leukemia	leukemia	NOUN
gs-4426	103	20	and	and	CCONJ
gs-4426	103	21	diffuse	diffuse	VERB
gs-4426	103	22	large	large	ADJ
gs-4426	103	23	b	b	NOUN
gs-4426	103	24	-	-	PUNCT
gs-4426	103	25	cell	cell	NOUN
gs-4426	103	26	lymphoma	lymphoma	NOUN
gs-4426	103	27	,	,	PUNCT
gs-4426	103	28	conducted	conduct	VERB
gs-4426	103	29	by	by	ADP
gs-4426	103	30	multiple	multiple	ADJ
gs-4426	103	31	academic	academic	ADJ
gs-4426	103	32	centers	center	NOUN
gs-4426	103	33	and	and	CCONJ
gs-4426	103	34	subsequently	subsequently	ADV
gs-4426	103	35	by	by	ADP
gs-4426	103	36	commercial	commercial	ADJ
gs-4426	103	37	developers	developer	NOUN
gs-4426	103	38	,	,	PUNCT
gs-4426	103	39	demonstrated	demonstrate	VERB
gs-4426	103	40	unprecedented	unprecedented	ADJ
gs-4426	103	41	complete	complete	ADJ
gs-4426	103	42	response	response	NOUN
gs-4426	103	43	rates	rate	NOUN
gs-4426	103	44	exceeding	exceed	VERB
gs-4426	103	45	50	50	NUM
gs-4426	103	46	-	-	SYM
gs-4426	103	47	80	80	NUM
gs-4426	103	48	%	%	NOUN
gs-4426	103	49	in	in	ADP
gs-4426	103	50	heavily	heavily	ADV
gs-4426	103	51	pre	pre	ADJ
gs-4426	103	52	-	-	ADJ
gs-4426	103	53	treated	treat	VERB
gs-4426	103	54	patient	patient	ADJ
gs-4426	103	55	populations	population	NOUN
gs-4426	103	56	with	with	ADP
gs-4426	103	57	dismal	dismal	ADJ
gs-4426	103	58	prognoses	prognosis	NOUN
gs-4426	103	59	using	use	VERB
gs-4426	103	60	conventional	conventional	ADJ
gs-4426	103	61	therapies	therapy	NOUN
gs-4426	103	62	.	.	PUNCT
gs-4426	104	1	long	long	ADJ
gs-4426	104	2	-	-	PUNCT
gs-4426	104	3	term	term	NOUN
gs-4426	104	4	follow	follow	NOUN
gs-4426	104	5	-	-	PUNCT
gs-4426	104	6	up	up	ADP
gs-4426	104	7	data	datum	NOUN
gs-4426	104	8	demonstrated	demonstrate	VERB
gs-4426	104	9	that	that	SCONJ
gs-4426	104	10	many	many	ADJ
gs-4426	104	11	patients	patient	NOUN
gs-4426	104	12	achieving	achieve	VERB
gs-4426	104	13	complete	complete	ADJ
gs-4426	104	14	responses	response	NOUN
gs-4426	104	15	experienced	experience	VERB
gs-4426	104	16	durable	durable	ADJ
gs-4426	104	17	remissions	remission	NOUN
gs-4426	104	18	lasting	last	VERB
gs-4426	104	19	years	year	NOUN
gs-4426	104	20	without	without	ADP
gs-4426	104	21	additional	additional	ADJ
gs-4426	104	22	therapy	therapy	NOUN
gs-4426	104	23	,	,	PUNCT
gs-4426	104	24	effectively	effectively	ADV
gs-4426	104	25	representing	represent	VERB
gs-4426	104	26	functional	functional	ADJ
gs-4426	104	27	cures	cure	NOUN
gs-4426	104	28	.	.	PUNCT
gs-4426	105	1	these	these	DET
gs-4426	105	2	remarkable	remarkable	ADJ
gs-4426	105	3	outcomes	outcome	NOUN
gs-4426	105	4	in	in	ADP
gs-4426	105	5	diseases	disease	NOUN
gs-4426	105	6	previously	previously	ADV
gs-4426	105	7	considered	consider	VERB
gs-4426	105	8	uniformly	uniformly	ADV
gs-4426	105	9	fatal	fatal	ADJ
gs-4426	105	10	transformed	transform	VERB
gs-4426	105	11	the	the	DET
gs-4426	105	12	treatment	treatment	NOUN
gs-4426	105	13	paradigm	paradigm	NOUN
gs-4426	105	14	for	for	ADP
gs-4426	105	15	certain	certain	ADJ
gs-4426	105	16	hematological	hematological	ADJ
gs-4426	105	17	malignancies	malignancy	NOUN
gs-4426	105	18	and	and	CCONJ
gs-4426	105	19	established	establish	VERB
gs-4426	105	20	car	car	NOUN
gs-4426	105	21	-	-	PUNCT
gs-4426	105	22	t	t	NOUN
gs-4426	105	23	therapy	therapy	NOUN
gs-4426	105	24	as	as	ADP
gs-4426	105	25	a	a	DET
gs-4426	105	26	standard	standard	NOUN
gs-4426	105	27	-	-	PUNCT
gs-4426	105	28	of	of	ADP
gs-4426	105	29	-	-	PUNCT
gs-4426	105	30	care	care	NOUN
gs-4426	105	31	option	option	NOUN
gs-4426	105	32	for	for	ADP
gs-4426	105	33	relapsed	relapse	VERB
gs-4426	105	34	/	/	SYM
gs-4426	105	35	refractory	refractory	NOUN
gs-4426	105	36	disease	disease	NOUN
gs-4426	105	37	.	.	PUNCT
gs-4426	106	1	the	the	DET
gs-4426	106	2	fda	fda	PROPN
gs-4426	106	3	approvals	approval	NOUN
gs-4426	106	4	of	of	ADP
gs-4426	106	5	kymriah	kymriah	PROPN
gs-4426	106	6	and	and	CCONJ
gs-4426	106	7	yescarta	yescarta	NOUN
gs-4426	106	8	in	in	ADP
gs-4426	106	9	2017	2017	NUM
gs-4426	106	10	,	,	PUNCT
gs-4426	106	11	followed	follow	VERB
gs-4426	106	12	by	by	ADP
gs-4426	106	13	additional	additional	ADJ
gs-4426	106	14	cd19	cd19	PROPN
gs-4426	106	15	-	-	PUNCT
gs-4426	106	16	directed	direct	VERB
gs-4426	106	17	products	product	NOUN
gs-4426	106	18	and	and	CCONJ
gs-4426	106	19	car	car	NOUN
gs-4426	106	20	-	-	PUNCT
gs-4426	106	21	t	t	NOUN
gs-4426	106	22	therapies	therapy	NOUN
gs-4426	106	23	targeting	target	VERB
gs-4426	106	24	other	other	ADJ
gs-4426	106	25	antigens	antigen	NOUN
gs-4426	106	26	including	include	VERB
gs-4426	106	27	bcma	bcma	NOUN
gs-4426	106	28	for	for	ADP
gs-4426	106	29	multiple	multiple	ADJ
gs-4426	106	30	myeloma	myeloma	NOUN
gs-4426	106	31	,	,	PUNCT
gs-4426	106	32	validated	validate	VERB
gs-4426	106	33	the	the	DET
gs-4426	106	34	therapeutic	therapeutic	ADJ
gs-4426	106	35	platform	platform	NOUN
gs-4426	106	36	and	and	CCONJ
gs-4426	106	37	stimulated	stimulate	VERB
gs-4426	106	38	extensive	extensive	ADJ
gs-4426	106	39	development	development	NOUN
gs-4426	106	40	of	of	ADP
gs-4426	106	41	next	next	ADJ
gs-4426	106	42	-	-	PUNCT
gs-4426	106	43	generation	generation	NOUN
gs-4426	106	44	cart	cart	NOUN
gs-4426	106	45	approaches	approach	NOUN
gs-4426	106	46	.	.	PUNCT
gs-4426	107	1	despite	despite	SCONJ
gs-4426	107	2	impressive	impressive	ADJ
gs-4426	107	3	efficacy	efficacy	NOUN
gs-4426	107	4	in	in	ADP
gs-4426	107	5	hematological	hematological	ADJ
gs-4426	107	6	malignancies	malignancy	NOUN
gs-4426	107	7	,	,	PUNCT
gs-4426	107	8	car	car	NOUN
gs-4426	107	9	-	-	PUNCT
gs-4426	107	10	t	t	NOUN
gs-4426	107	11	therapy	therapy	NOUN
gs-4426	107	12	faces	face	VERB
gs-4426	107	13	substantial	substantial	ADJ
gs-4426	107	14	challenges	challenge	NOUN
gs-4426	107	15	including	include	VERB
gs-4426	107	16	severe	severe	ADJ
gs-4426	107	17	toxicities	toxicity	NOUN
gs-4426	107	18	,	,	PUNCT
gs-4426	107	19	manufacturing	manufacturing	NOUN
gs-4426	107	20	complexity	complexity	NOUN
gs-4426	107	21	,	,	PUNCT
gs-4426	107	22	high	high	ADJ
gs-4426	107	23	costs	cost	NOUN
gs-4426	107	24	,	,	PUNCT
gs-4426	107	25	and	and	CCONJ
gs-4426	107	26	limited	limited	ADJ
gs-4426	107	27	efficacy	efficacy	NOUN
gs-4426	107	28	against	against	ADP
gs-4426	107	29	solid	solid	ADJ
gs-4426	107	30	tumors	tumor	NOUN
gs-4426	107	31	.	.	PUNCT
gs-4426	108	1	cytokine	cytokine	ADJ
gs-4426	108	2	release	release	NOUN
gs-4426	108	3	syndrome	syndrome	NOUN
gs-4426	108	4	,	,	PUNCT
gs-4426	108	5	resulting	result	VERB
gs-4426	108	6	from	from	ADP
gs-4426	108	7	massive	massive	ADJ
gs-4426	108	8	activation	activation	NOUN
gs-4426	108	9	and	and	CCONJ
gs-4426	108	10	expansion	expansion	NOUN
gs-4426	108	11	of	of	ADP
gs-4426	108	12	car	car	NOUN
gs-4426	108	13	-	-	PUNCT
gs-4426	108	14	t	t	NOUN
gs-4426	108	15	cells	cell	NOUN
gs-4426	108	16	triggering	trigger	VERB
gs-4426	108	17	systemic	systemic	ADJ
gs-4426	108	18	inflammatory	inflammatory	ADJ
gs-4426	108	19	cytokine	cytokine	NOUN
gs-4426	108	20	secretion	secretion	NOUN
gs-4426	108	21	,	,	PUNCT
gs-4426	108	22	occurs	occur	VERB
gs-4426	108	23	in	in	ADP
gs-4426	108	24	the	the	DET
gs-4426	108	25	majority	majority	NOUN
gs-4426	108	26	of	of	ADP
gs-4426	108	27	patients	patient	NOUN
gs-4426	108	28	with	with	ADP
gs-4426	108	29	severity	severity	NOUN
gs-4426	108	30	ranging	range	VERB
gs-4426	108	31	from	from	ADP
gs-4426	108	32	mild	mild	ADJ
gs-4426	108	33	flu	flu	NOUN
gs-4426	108	34	-	-	PUNCT
gs-4426	108	35	like	like	ADJ
gs-4426	108	36	symptoms	symptom	NOUN
gs-4426	108	37	to	to	ADP
gs-4426	108	38	life	life	NOUN
gs-4426	108	39	-	-	PUNCT
gs-4426	108	40	threatening	threaten	VERB
gs-4426	108	41	hemodynamic	hemodynamic	ADJ
gs-4426	108	42	instability	instability	NOUN
gs-4426	108	43	requiring	require	VERB
gs-4426	108	44	intensive	intensive	ADJ
gs-4426	108	45	care	care	NOUN
gs-4426	108	46	support	support	NOUN
gs-4426	108	47	.	.	PUNCT
gs-4426	109	1	the	the	DET
gs-4426	109	2	identification	identification	NOUN
gs-4426	109	3	of	of	ADP
gs-4426	109	4	interleukin-6	interleukin-6	NUM
gs-4426	109	5	as	as	ADP
gs-4426	109	6	a	a	DET
gs-4426	109	7	key	key	ADJ
gs-4426	109	8	mediator	mediator	NOUN
gs-4426	109	9	led	lead	VERB
gs-4426	109	10	to	to	ADP
gs-4426	109	11	the	the	DET
gs-4426	109	12	use	use	NOUN
gs-4426	109	13	of	of	ADP
gs-4426	109	14	tocilizumab	tocilizumab	NOUN
gs-4426	109	15	,	,	PUNCT
gs-4426	109	16	an	an	DET
gs-4426	109	17	il-6	il-6	NOUN
gs-4426	109	18	receptor	receptor	NOUN
gs-4426	109	19	antagonist	antagonist	NOUN
gs-4426	109	20	,	,	PUNCT
gs-4426	109	21	for	for	ADP
gs-4426	109	22	managing	manage	VERB
gs-4426	109	23	severe	severe	ADJ
gs-4426	109	24	cytokine	cytokine	NOUN
gs-4426	109	25	release	release	NOUN
gs-4426	109	26	syndrome	syndrome	NOUN
gs-4426	109	27	,	,	PUNCT
gs-4426	109	28	substantially	substantially	ADV
gs-4426	109	29	improving	improve	VERB
gs-4426	109	30	safety	safety	NOUN
gs-4426	109	31	profiles	profile	NOUN
gs-4426	109	32	.	.	PUNCT
gs-4426	110	1	immune	immune	ADJ
gs-4426	110	2	effector	effector	NOUN
gs-4426	110	3	cell	cell	NOUN
gs-4426	110	4	-	-	PUNCT
gs-4426	110	5	associated	associate	VERB
gs-4426	110	6	neurotoxicity	neurotoxicity	NOUN
gs-4426	110	7	syndrome	syndrome	NOUN
gs-4426	110	8	,	,	PUNCT
gs-4426	110	9	manifesting	manifest	VERB
gs-4426	110	10	as	as	ADP
gs-4426	110	11	confusion	confusion	NOUN
gs-4426	110	12	,	,	PUNCT
gs-4426	110	13	aphasia	aphasia	NOUN
gs-4426	110	14	,	,	PUNCT
gs-4426	110	15	seizures	seizure	NOUN
gs-4426	110	16	,	,	PUNCT
gs-4426	110	17	and	and	CCONJ
gs-4426	110	18	potentially	potentially	ADV
gs-4426	110	19	fatal	fatal	ADJ
gs-4426	110	20	cerebral	cerebral	ADJ
gs-4426	110	21	edema	edema	NOUN
gs-4426	110	22	,	,	PUNCT
gs-4426	110	23	represents	represent	VERB
gs-4426	110	24	another	another	DET
gs-4426	110	25	serious	serious	ADJ
gs-4426	110	26	toxicity	toxicity	NOUN
gs-4426	110	27	requiring	require	VERB
gs-4426	110	28	specialized	specialized	ADJ
gs-4426	110	29	management	management	NOUN
gs-4426	110	30	.	.	PUNCT
gs-4426	111	1	understanding	understanding	NOUN
gs-4426	111	2	and	and	CCONJ
gs-4426	111	3	mitigation	mitigation	NOUN
gs-4426	111	4	of	of	ADP
gs-4426	111	5	these	these	DET
gs-4426	111	6	toxicities	toxicity	NOUN
gs-4426	111	7	through	through	ADP
gs-4426	111	8	optimized	optimize	VERB
gs-4426	111	9	car	car	NOUN
gs-4426	111	10	designs	design	NOUN
gs-4426	111	11	,	,	PUNCT
gs-4426	111	12	dose	dose	NOUN
gs-4426	111	13	adjustments	adjustment	NOUN
gs-4426	111	14	,	,	PUNCT
gs-4426	111	15	and	and	CCONJ
gs-4426	111	16	early	early	ADJ
gs-4426	111	17	intervention	intervention	NOUN
gs-4426	111	18	with	with	ADP
gs-4426	111	19	immunosuppressive	immunosuppressive	ADJ
gs-4426	111	20	agents	agent	NOUN
gs-4426	111	21	remain	remain	VERB
gs-4426	111	22	active	active	ADJ
gs-4426	111	23	areas	area	NOUN
gs-4426	111	24	of	of	ADP
gs-4426	111	25	investigation	investigation	NOUN
gs-4426	111	26	aimed	aim	VERB
gs-4426	111	27	at	at	ADP
gs-4426	111	28	broadening	broaden	VERB
gs-4426	111	29	the	the	DET
gs-4426	111	30	therapeutic	therapeutic	ADJ
gs-4426	111	31	window	window	NOUN
gs-4426	111	32	.	.	PUNCT
gs-4426	112	1	the	the	DET
gs-4426	112	2	extension	extension	NOUN
gs-4426	112	3	of	of	ADP
gs-4426	112	4	car	car	NOUN
gs-4426	112	5	-	-	PUNCT
gs-4426	112	6	t	t	NOUN
gs-4426	112	7	therapy	therapy	NOUN
gs-4426	112	8	to	to	ADP
gs-4426	112	9	solid	solid	ADJ
gs-4426	112	10	tumors	tumor	NOUN
gs-4426	112	11	has	have	AUX
gs-4426	112	12	proven	prove	VERB
gs-4426	112	13	substantially	substantially	ADV
gs-4426	112	14	more	more	ADV
gs-4426	112	15	challenging	challenging	ADJ
gs-4426	112	16	than	than	ADP
gs-4426	112	17	hematological	hematological	ADJ
gs-4426	112	18	applications	application	NOUN
gs-4426	112	19	due	due	ADP
gs-4426	112	20	to	to	ADP
gs-4426	112	21	multiple	multiple	ADJ
gs-4426	112	22	obstacles	obstacle	NOUN
gs-4426	112	23	including	include	VERB
gs-4426	112	24	lack	lack	NOUN
gs-4426	112	25	of	of	ADP
gs-4426	112	26	tumor	tumor	NOUN
gs-4426	112	27	-	-	PUNCT
gs-4426	112	28	specific	specific	ADJ
gs-4426	112	29	surface	surface	NOUN
gs-4426	112	30	antigens	antigen	NOUN
gs-4426	112	31	,	,	PUNCT
gs-4426	112	32	limited	limited	ADJ
gs-4426	112	33	t	t	PROPN
gs-4426	112	34	-	-	PUNCT
gs-4426	112	35	cell	cell	NOUN
gs-4426	112	36	infiltration	infiltration	NOUN
gs-4426	112	37	and	and	CCONJ
gs-4426	112	38	trafficking	traffic	VERB
gs-4426	112	39	to	to	ADP
gs-4426	112	40	tumor	tumor	NOUN
gs-4426	112	41	sites	site	NOUN
gs-4426	112	42	,	,	PUNCT
gs-4426	112	43	immunosuppressive	immunosuppressive	ADJ
gs-4426	112	44	tumor	tumor	NOUN
gs-4426	112	45	microenvironments	microenvironment	NOUN
gs-4426	112	46	,	,	PUNCT
gs-4426	112	47	and	and	CCONJ
gs-4426	112	48	antigen	antigen	ADJ
gs-4426	112	49	heterogeneity	heterogeneity	NOUN
gs-4426	112	50	enabling	enable	VERB
gs-4426	112	51	immune	immune	ADJ
gs-4426	112	52	escape	escape	NOUN
gs-4426	112	53	through	through	ADP
gs-4426	112	54	antigen	antigen	NOUN
gs-4426	112	55	-	-	PUNCT
gs-4426	112	56	negative	negative	ADJ
gs-4426	112	57	tumor	tumor	NOUN
gs-4426	112	58	variants	variant	NOUN
gs-4426	112	59	.	.	PUNCT
gs-4426	113	1	current	current	ADJ
gs-4426	113	2	strategies	strategy	NOUN
gs-4426	113	3	addressing	address	VERB
gs-4426	113	4	these	these	DET
gs-4426	113	5	challenges	challenge	NOUN
gs-4426	113	6	include	include	VERB
gs-4426	113	7	targeting	target	VERB
gs-4426	113	8	multiple	multiple	ADJ
gs-4426	113	9	antigens	antigen	NOUN
gs-4426	113	10	simultaneously	simultaneously	ADV
gs-4426	113	11	to	to	PART
gs-4426	113	12	prevent	prevent	VERB
gs-4426	113	13	escape	escape	NOUN
gs-4426	113	14	,	,	PUNCT
gs-4426	113	15	engineering	engineering	NOUN
gs-4426	113	16	car	car	NOUN
gs-4426	113	17	-	-	PUNCT
gs-4426	113	18	t	t	NOUN
gs-4426	113	19	cells	cell	NOUN
gs-4426	113	20	to	to	PART
gs-4426	113	21	secrete	secrete	VERB
gs-4426	113	22	immunomodulatory	immunomodulatory	ADJ
gs-4426	113	23	cytokines	cytokine	NOUN
gs-4426	113	24	that	that	PRON
gs-4426	113	25	remodel	remodel	VERB
gs-4426	113	26	the	the	DET
gs-4426	113	27	tumor	tumor	NOUN
gs-4426	113	28	microenvironment	microenvironment	NOUN
gs-4426	113	29	,	,	PUNCT
gs-4426	113	30	combining	combine	VERB
gs-4426	113	31	car	car	NOUN
gs-4426	113	32	-	-	PUNCT
gs-4426	113	33	t	t	NOUN
gs-4426	113	34	therapy	therapy	NOUN
gs-4426	113	35	with	with	ADP
gs-4426	113	36	checkpoint	checkpoint	NOUN
gs-4426	113	37	inhibitors	inhibitor	NOUN
gs-4426	113	38	to	to	PART
gs-4426	113	39	overcome	overcome	VERB
gs-4426	113	40	t	t	PROPN
gs-4426	113	41	-	-	PUNCT
gs-4426	113	42	cell	cell	NOUN
gs-4426	113	43	exhaustion	exhaustion	NOUN
gs-4426	113	44	,	,	PUNCT
gs-4426	113	45	and	and	CCONJ
gs-4426	113	46	developing	develop	VERB
gs-4426	113	47	car	car	NOUN
gs-4426	113	48	-	-	PUNCT
gs-4426	113	49	t	t	NOUN
gs-4426	113	50	cells	cell	NOUN
gs-4426	113	51	with	with	ADP
gs-4426	113	52	switchable	switchable	ADJ
gs-4426	113	53	or	or	CCONJ
gs-4426	113	54	tunable	tunable	ADJ
gs-4426	113	55	activity	activity	NOUN
gs-4426	113	56	to	to	PART
gs-4426	113	57	improve	improve	VERB
gs-4426	113	58	safety	safety	NOUN
gs-4426	113	59	and	and	CCONJ
gs-4426	113	60	enable	enable	VERB
gs-4426	113	61	prolonged	prolonged	ADJ
gs-4426	113	62	anti	anti	ADJ
gs-4426	113	63	-	-	ADJ
gs-4426	113	64	tumor	tumor	ADJ
gs-4426	113	65	responses	response	NOUN
gs-4426	113	66	.	.	PUNCT
gs-4426	114	1	regional	regional	ADJ
gs-4426	114	2	delivery	delivery	NOUN
gs-4426	114	3	approaches	approach	NOUN
gs-4426	114	4	including	include	VERB
gs-4426	114	5	intraperitoneal	intraperitoneal	NOUN
gs-4426	114	6	,	,	PUNCT
gs-4426	114	7	intrathecal	intrathecal	ADJ
gs-4426	114	8	,	,	PUNCT
gs-4426	114	9	or	or	CCONJ
gs-4426	114	10	intratumoral	intratumoral	ADJ
gs-4426	114	11	administration	administration	NOUN
gs-4426	114	12	aim	aim	VERB
gs-4426	114	13	to	to	PART
gs-4426	114	14	enhance	enhance	VERB
gs-4426	114	15	local	local	ADJ
gs-4426	114	16	car	car	NOUN
gs-4426	114	17	-	-	PUNCT
gs-4426	114	18	t	t	NOUN
gs-4426	114	19	cell	cell	NOUN
gs-4426	114	20	concentrations	concentration	NOUN
gs-4426	114	21	while	while	SCONJ
gs-4426	114	22	limiting	limit	VERB
gs-4426	114	23	systemic	systemic	ADJ
gs-4426	114	24	toxicities	toxicity	NOUN
gs-4426	114	25	.	.	PUNCT
gs-4426	115	1	despite	despite	SCONJ
gs-4426	115	2	these	these	DET
gs-4426	115	3	challenges	challenge	NOUN
gs-4426	115	4	,	,	PUNCT
gs-4426	115	5	early	early	ADJ
gs-4426	115	6	clinical	clinical	ADJ
gs-4426	115	7	data	datum	NOUN
gs-4426	115	8	from	from	ADP
gs-4426	115	9	georgian	georgian	PROPN
gs-4426	115	10	scientists/	scientists/	NUM
gs-4426	115	11	.	.	PUNCT
gs-4426	116	1	7	7	NUM
gs-4426	116	2	n	n	DET
gs-4426	116	3	4	4	NUM
gs-4426	116	4	,	,	PUNCT
gs-4426	116	5	2025	2025	NUM
gs-4426	116	6	600	600	NUM
gs-4426	116	7	solid	solid	ADJ
gs-4426	116	8	tumor	tumor	NOUN
gs-4426	116	9	car	car	NOUN
gs-4426	116	10	-	-	PUNCT
gs-4426	116	11	t	t	NOUN
gs-4426	116	12	trials	trial	NOUN
gs-4426	116	13	demonstrate	demonstrate	VERB
gs-4426	116	14	proof	proof	NOUN
gs-4426	116	15	-	-	PUNCT
gs-4426	116	16	of	of	ADP
gs-4426	116	17	-	-	PUNCT
gs-4426	116	18	concept	concept	NOUN
gs-4426	116	19	efficacy	efficacy	NOUN
gs-4426	116	20	in	in	ADP
gs-4426	116	21	selected	select	VERB
gs-4426	116	22	patients	patient	NOUN
gs-4426	116	23	,	,	PUNCT
gs-4426	116	24	suggesting	suggest	VERB
gs-4426	116	25	that	that	SCONJ
gs-4426	116	26	further	further	ADJ
gs-4426	116	27	refinements	refinement	NOUN
gs-4426	116	28	may	may	AUX
gs-4426	116	29	enable	enable	VERB
gs-4426	116	30	broader	broad	ADJ
gs-4426	116	31	solid	solid	ADJ
gs-4426	116	32	tumor	tumor	NOUN
gs-4426	116	33	applications	application	NOUN
gs-4426	116	34	.	.	PUNCT
gs-4426	117	1	expanding	expand	VERB
gs-4426	117	2	applications	application	NOUN
gs-4426	117	3	to	to	ADP
gs-4426	117	4	common	common	ADJ
gs-4426	117	5	diseases	disease	NOUN
gs-4426	117	6	the	the	DET
gs-4426	117	7	successful	successful	ADJ
gs-4426	117	8	clinical	clinical	ADJ
gs-4426	117	9	translation	translation	NOUN
gs-4426	117	10	of	of	ADP
gs-4426	117	11	gene	gene	NOUN
gs-4426	117	12	therapy	therapy	NOUN
gs-4426	117	13	for	for	ADP
gs-4426	117	14	rare	rare	ADJ
gs-4426	117	15	monogenic	monogenic	ADJ
gs-4426	117	16	disorders	disorder	NOUN
gs-4426	117	17	has	have	AUX
gs-4426	117	18	catalyzed	catalyze	VERB
gs-4426	117	19	expansion	expansion	NOUN
gs-4426	117	20	toward	toward	ADP
gs-4426	117	21	more	more	ADJ
gs-4426	117	22	prevalent	prevalent	ADJ
gs-4426	117	23	diseases	disease	NOUN
gs-4426	117	24	affecting	affect	VERB
gs-4426	117	25	larger	large	ADJ
gs-4426	117	26	patient	patient	ADJ
gs-4426	117	27	populations	population	NOUN
gs-4426	117	28	,	,	PUNCT
gs-4426	117	29	potentially	potentially	ADV
gs-4426	117	30	amplifying	amplify	VERB
gs-4426	117	31	public	public	ADJ
gs-4426	117	32	health	health	NOUN
gs-4426	117	33	impact	impact	NOUN
gs-4426	117	34	while	while	SCONJ
gs-4426	117	35	also	also	ADV
gs-4426	117	36	raising	raise	VERB
gs-4426	117	37	questions	question	NOUN
gs-4426	117	38	about	about	ADP
gs-4426	117	39	healthcare	healthcare	NOUN
gs-4426	117	40	system	system	NOUN
gs-4426	117	41	capacity	capacity	NOUN
gs-4426	117	42	and	and	CCONJ
gs-4426	117	43	resource	resource	NOUN
gs-4426	117	44	allocation	allocation	NOUN
gs-4426	117	45	.	.	PUNCT
gs-4426	118	1	cardiovascular	cardiovascular	ADJ
gs-4426	118	2	disease	disease	NOUN
gs-4426	118	3	,	,	PUNCT
gs-4426	118	4	the	the	DET
gs-4426	118	5	leading	lead	VERB
gs-4426	118	6	cause	cause	NOUN
gs-4426	118	7	of	of	ADP
gs-4426	118	8	mortality	mortality	NOUN
gs-4426	118	9	globally	globally	ADV
gs-4426	118	10	accounting	account	VERB
gs-4426	118	11	for	for	ADP
gs-4426	118	12	approximately	approximately	ADV
gs-4426	118	13	18	18	NUM
gs-4426	118	14	million	million	NUM
gs-4426	118	15	deaths	death	NOUN
gs-4426	118	16	annually	annually	ADV
gs-4426	118	17	,	,	PUNCT
gs-4426	118	18	represents	represent	VERB
gs-4426	118	19	an	an	DET
gs-4426	118	20	enormous	enormous	ADJ
gs-4426	118	21	potential	potential	ADJ
gs-4426	118	22	application	application	NOUN
gs-4426	118	23	for	for	ADP
gs-4426	118	24	gene	gene	NOUN
gs-4426	118	25	therapy	therapy	NOUN
gs-4426	118	26	approaches	approach	VERB
gs-4426	118	27	targeting	target	VERB
gs-4426	118	28	modifiable	modifiable	ADJ
gs-4426	118	29	risk	risk	NOUN
gs-4426	118	30	factors	factor	NOUN
gs-4426	118	31	including	include	VERB
gs-4426	118	32	hyperlipidemia	hyperlipidemia	NOUN
gs-4426	118	33	,	,	PUNCT
gs-4426	118	34	hypertension	hypertension	NOUN
gs-4426	118	35	,	,	PUNCT
gs-4426	118	36	and	and	CCONJ
gs-4426	118	37	thrombotic	thrombotic	ADJ
gs-4426	118	38	tendency	tendency	NOUN
gs-4426	118	39	.	.	PUNCT
gs-4426	119	1	crispr	crispr	NOUN
gs-4426	119	2	-	-	PUNCT
gs-4426	119	3	based	base	VERB
gs-4426	119	4	strategies	strategy	NOUN
gs-4426	119	5	for	for	ADP
gs-4426	119	6	permanent	permanent	ADJ
gs-4426	119	7	reduction	reduction	NOUN
gs-4426	119	8	of	of	ADP
gs-4426	119	9	circulating	circulate	VERB
gs-4426	119	10	cholesterol	cholesterol	NOUN
gs-4426	119	11	through	through	ADP
gs-4426	119	12	targeted	target	VERB
gs-4426	119	13	disruption	disruption	NOUN
gs-4426	119	14	of	of	ADP
gs-4426	119	15	the	the	DET
gs-4426	119	16	pcsk9	pcsk9	PROPN
gs-4426	119	17	gene	gene	NOUN
gs-4426	119	18	in	in	ADP
gs-4426	119	19	hepatocytes	hepatocyte	NOUN
gs-4426	119	20	have	have	AUX
gs-4426	119	21	advanced	advance	VERB
gs-4426	119	22	to	to	ADP
gs-4426	119	23	early	early	ADJ
gs-4426	119	24	clinical	clinical	ADJ
gs-4426	119	25	trials	trial	NOUN
gs-4426	119	26	with	with	ADP
gs-4426	119	27	highly	highly	ADV
gs-4426	119	28	encouraging	encouraging	ADJ
gs-4426	119	29	preliminary	preliminary	ADJ
gs-4426	119	30	results	result	NOUN
gs-4426	119	31	(	(	PUNCT
gs-4426	119	32	davies	davy	NOUN
gs-4426	119	33	et	et	PROPN
gs-4426	119	34	al	al	PROPN
gs-4426	119	35	.	.	PROPN
gs-4426	119	36	,	,	PUNCT
gs-4426	119	37	2024	2024	NUM
gs-4426	119	38	)	)	PUNCT
gs-4426	119	39	.	.	PUNCT
gs-4426	120	1	pcsk9	pcsk9	PROPN
gs-4426	120	2	is	be	AUX
gs-4426	120	3	a	a	DET
gs-4426	120	4	proprotein	proprotein	ADJ
gs-4426	120	5	convertase	convertase	NOUN
gs-4426	120	6	that	that	PRON
gs-4426	120	7	promotes	promote	VERB
gs-4426	120	8	degradation	degradation	NOUN
gs-4426	120	9	of	of	ADP
gs-4426	120	10	low	low	ADJ
gs-4426	120	11	-	-	PUNCT
gs-4426	120	12	density	density	NOUN
gs-4426	120	13	lipoprotein	lipoprotein	ADJ
gs-4426	120	14	receptors	receptor	NOUN
gs-4426	120	15	on	on	ADP
gs-4426	120	16	hepatocyte	hepatocyte	NOUN
gs-4426	120	17	surfaces	surface	NOUN
gs-4426	120	18	;	;	PUNCT
gs-4426	120	19	reducing	reduce	VERB
gs-4426	120	20	pcsk9	pcsk9	NOUN
gs-4426	120	21	expression	expression	NOUN
gs-4426	120	22	increases	increase	VERB
gs-4426	120	23	receptor	receptor	NOUN
gs-4426	120	24	availability	availability	NOUN
gs-4426	120	25	and	and	CCONJ
gs-4426	120	26	enhances	enhance	VERB
gs-4426	120	27	clearance	clearance	NOUN
gs-4426	120	28	of	of	ADP
gs-4426	120	29	cholesterol	cholesterol	NOUN
gs-4426	120	30	-	-	PUNCT
gs-4426	120	31	rich	rich	ADJ
gs-4426	120	32	lipoproteins	lipoprotein	NOUN
gs-4426	120	33	from	from	ADP
gs-4426	120	34	circulation	circulation	NOUN
gs-4426	120	35	,	,	PUNCT
gs-4426	120	36	thereby	thereby	ADV
gs-4426	120	37	lowering	lower	VERB
gs-4426	120	38	cardiovascular	cardiovascular	ADJ
gs-4426	120	39	risk	risk	NOUN
gs-4426	120	40	.	.	PUNCT
gs-4426	121	1	early	early	ADJ
gs-4426	121	2	-	-	PUNCT
gs-4426	121	3	phase	phase	NOUN
gs-4426	121	4	clinical	clinical	ADJ
gs-4426	121	5	trials	trial	NOUN
gs-4426	121	6	of	of	ADP
gs-4426	121	7	in	in	ADP
gs-4426	121	8	vivo	vivo	ADJ
gs-4426	121	9	crispr	crispr	NOUN
gs-4426	121	10	editing	edit	VERB
gs-4426	121	11	targeting	target	VERB
gs-4426	121	12	pcsk9	pcsk9	NOUN
gs-4426	121	13	in	in	ADP
gs-4426	121	14	patients	patient	NOUN
gs-4426	121	15	with	with	ADP
gs-4426	121	16	heterozygous	heterozygous	ADJ
gs-4426	121	17	familial	familial	ADJ
gs-4426	121	18	hypercholesterolemia	hypercholesterolemia	NOUN
gs-4426	121	19	or	or	CCONJ
gs-4426	121	20	atherosclerotic	atherosclerotic	ADJ
gs-4426	121	21	cardiovascular	cardiovascular	ADJ
gs-4426	121	22	disease	disease	NOUN
gs-4426	121	23	have	have	AUX
gs-4426	121	24	demonstrated	demonstrate	VERB
gs-4426	121	25	proofof	proofof	ADJ
gs-4426	121	26	-	-	PUNCT
gs-4426	121	27	concept	concept	NOUN
gs-4426	121	28	efficacy	efficacy	NOUN
gs-4426	121	29	with	with	ADP
gs-4426	121	30	single	single	ADJ
gs-4426	121	31	-	-	PUNCT
gs-4426	121	32	administration	administration	NOUN
gs-4426	121	33	treatment	treatment	NOUN
gs-4426	121	34	producing	produce	VERB
gs-4426	121	35	sustained	sustain	VERB
gs-4426	121	36	reductions	reduction	NOUN
gs-4426	121	37	in	in	ADP
gs-4426	121	38	ldl	ldl	NOUN
gs-4426	121	39	cholesterol	cholesterol	NOUN
gs-4426	121	40	and	and	CCONJ
gs-4426	121	41	triglycerides	triglyceride	NOUN
gs-4426	121	42	extending	extend	VERB
gs-4426	121	43	through	through	ADP
gs-4426	121	44	twelve	twelve	NUM
gs-4426	121	45	months	month	NOUN
gs-4426	121	46	of	of	ADP
gs-4426	121	47	follow	follow	NOUN
gs-4426	121	48	-	-	PUNCT
gs-4426	121	49	up	up	NOUN
gs-4426	121	50	.	.	PUNCT
gs-4426	122	1	participants	participant	NOUN
gs-4426	122	2	receiving	receive	VERB
gs-4426	122	3	the	the	DET
gs-4426	122	4	therapy	therapy	NOUN
gs-4426	122	5	achieved	achieve	VERB
gs-4426	122	6	average	average	ADJ
gs-4426	122	7	ldl	ldl	NOUN
gs-4426	122	8	cholesterol	cholesterol	NOUN
gs-4426	122	9	reductions	reduction	NOUN
gs-4426	122	10	of	of	ADP
gs-4426	122	11	40	40	NUM
gs-4426	122	12	-	-	SYM
gs-4426	122	13	55	55	NUM
gs-4426	122	14	%	%	NOUN
gs-4426	122	15	from	from	ADP
gs-4426	122	16	baseline	baseline	NOUN
gs-4426	122	17	without	without	ADP
gs-4426	122	18	concurrent	concurrent	ADJ
gs-4426	122	19	statin	statin	PROPN
gs-4426	122	20	therapy	therapy	NOUN
gs-4426	122	21	,	,	PUNCT
gs-4426	122	22	comparable	comparable	ADJ
gs-4426	122	23	to	to	ADP
gs-4426	122	24	the	the	DET
gs-4426	122	25	effect	effect	NOUN
gs-4426	122	26	achieved	achieve	VERB
gs-4426	122	27	by	by	ADP
gs-4426	122	28	daily	daily	PROPN
gs-4426	122	29	statin	statin	PROPN
gs-4426	122	30	administration	administration	NOUN
gs-4426	122	31	plus	plus	CCONJ
gs-4426	122	32	monthly	monthly	ADJ
gs-4426	122	33	pcsk9	pcsk9	NOUN
gs-4426	122	34	inhibitor	inhibitor	NOUN
gs-4426	122	35	injections	injection	NOUN
gs-4426	122	36	.	.	PUNCT
gs-4426	123	1	the	the	DET
gs-4426	123	2	potential	potential	NOUN
gs-4426	123	3	to	to	PART
gs-4426	123	4	achieve	achieve	VERB
gs-4426	123	5	lifelong	lifelong	ADJ
gs-4426	123	6	cholesterol	cholesterol	NOUN
gs-4426	123	7	reduction	reduction	NOUN
gs-4426	123	8	through	through	ADP
gs-4426	123	9	single	single	ADJ
gs-4426	123	10	treatment	treatment	NOUN
gs-4426	123	11	,	,	PUNCT
gs-4426	123	12	thereby	thereby	ADV
gs-4426	123	13	eliminating	eliminate	VERB
gs-4426	123	14	adherence	adherence	NOUN
gs-4426	123	15	challenges	challenge	NOUN
gs-4426	123	16	associated	associate	VERB
gs-4426	123	17	with	with	ADP
gs-4426	123	18	daily	daily	ADJ
gs-4426	123	19	oral	oral	ADJ
gs-4426	123	20	medications	medication	NOUN
gs-4426	123	21	or	or	CCONJ
gs-4426	123	22	frequent	frequent	ADJ
gs-4426	123	23	injections	injection	NOUN
gs-4426	123	24	,	,	PUNCT
gs-4426	123	25	represents	represent	VERB
gs-4426	123	26	a	a	DET
gs-4426	123	27	transformative	transformative	ADJ
gs-4426	123	28	advance	advance	NOUN
gs-4426	123	29	if	if	SCONJ
gs-4426	123	30	long	long	ADJ
gs-4426	123	31	-	-	PUNCT
gs-4426	123	32	term	term	NOUN
gs-4426	123	33	safety	safety	NOUN
gs-4426	123	34	and	and	CCONJ
gs-4426	123	35	durability	durability	NOUN
gs-4426	123	36	are	be	AUX
gs-4426	123	37	confirmed	confirm	VERB
gs-4426	123	38	in	in	ADP
gs-4426	123	39	larger	large	ADJ
gs-4426	123	40	trials	trial	NOUN
gs-4426	123	41	with	with	ADP
gs-4426	123	42	extended	extended	ADJ
gs-4426	123	43	follow	follow	NOUN
gs-4426	123	44	-	-	PUNCT
gs-4426	123	45	up	up	NOUN
gs-4426	123	46	.	.	PUNCT
gs-4426	124	1	similar	similar	ADJ
gs-4426	124	2	approaches	approach	NOUN
gs-4426	124	3	targeting	target	VERB
gs-4426	124	4	other	other	ADJ
gs-4426	124	5	cardiovascular	cardiovascular	ADJ
gs-4426	124	6	risk	risk	NOUN
gs-4426	124	7	genes	gene	NOUN
gs-4426	124	8	including	include	VERB
gs-4426	124	9	angptl3	angptl3	NOUN
gs-4426	124	10	and	and	CCONJ
gs-4426	124	11	lipoprotein(a	lipoprotein(a	PROPN
gs-4426	124	12	)	)	PUNCT
gs-4426	124	13	are	be	AUX
gs-4426	124	14	in	in	ADP
gs-4426	124	15	development	development	NOUN
gs-4426	124	16	,	,	PUNCT
gs-4426	124	17	potentially	potentially	ADV
gs-4426	124	18	offering	offer	VERB
gs-4426	124	19	treatment	treatment	NOUN
gs-4426	124	20	options	option	NOUN
gs-4426	124	21	for	for	ADP
gs-4426	124	22	patients	patient	NOUN
gs-4426	124	23	’	'	PUNCT
gs-4426	124	24	intolerant	intolerant	ADJ
gs-4426	124	25	of	of	ADP
gs-4426	124	26	or	or	CCONJ
gs-4426	124	27	inadequately	inadequately	ADV
gs-4426	124	28	responsive	responsive	ADJ
gs-4426	124	29	to	to	ADP
gs-4426	124	30	conventional	conventional	ADJ
gs-4426	124	31	lipid	lipid	NOUN
gs-4426	124	32	-	-	PUNCT
gs-4426	124	33	lowering	lower	VERB
gs-4426	124	34	therapies	therapy	NOUN
gs-4426	124	35	.	.	PUNCT
gs-4426	125	1	type	type	NOUN
gs-4426	125	2	1	1	NUM
gs-4426	125	3	diabetes	diabete	NOUN
gs-4426	125	4	,	,	PUNCT
gs-4426	125	5	an	an	DET
gs-4426	125	6	autoimmune	autoimmune	ADJ
gs-4426	125	7	disorder	disorder	NOUN
gs-4426	125	8	characterized	characterize	VERB
gs-4426	125	9	by	by	ADP
gs-4426	125	10	destruction	destruction	NOUN
gs-4426	125	11	of	of	ADP
gs-4426	125	12	insulin	insulin	NOUN
gs-4426	125	13	-	-	PUNCT
gs-4426	125	14	producing	produce	VERB
gs-4426	125	15	pancreatic	pancreatic	ADJ
gs-4426	125	16	beta	beta	NOUN
gs-4426	125	17	cells	cell	NOUN
gs-4426	125	18	requiring	require	VERB
gs-4426	125	19	lifelong	lifelong	ADJ
gs-4426	125	20	insulin	insulin	NOUN
gs-4426	125	21	administration	administration	NOUN
gs-4426	125	22	,	,	PUNCT
gs-4426	125	23	affects	affect	VERB
gs-4426	125	24	approximately	approximately	ADV
gs-4426	125	25	1.6	1.6	NUM
gs-4426	125	26	million	million	NUM
gs-4426	125	27	americans	americans	PROPN
gs-4426	125	28	and	and	CCONJ
gs-4426	125	29	represents	represent	VERB
gs-4426	125	30	another	another	DET
gs-4426	125	31	potential	potential	ADJ
gs-4426	125	32	gene	gene	NOUN
gs-4426	125	33	therapy	therapy	NOUN
gs-4426	125	34	target	target	NOUN
gs-4426	125	35	.	.	PUNCT
gs-4426	126	1	current	current	ADJ
gs-4426	126	2	approaches	approach	NOUN
gs-4426	126	3	under	under	ADP
gs-4426	126	4	clinical	clinical	ADJ
gs-4426	126	5	investigation	investigation	NOUN
gs-4426	126	6	include	include	VERB
gs-4426	126	7	encapsulation	encapsulation	NOUN
gs-4426	126	8	of	of	ADP
gs-4426	126	9	engineered	engineer	VERB
gs-4426	126	10	insulin	insulin	NOUN
gs-4426	126	11	-	-	PUNCT
gs-4426	126	12	producing	produce	VERB
gs-4426	126	13	cells	cell	NOUN
gs-4426	126	14	derived	derive	VERB
gs-4426	126	15	from	from	ADP
gs-4426	126	16	stem	stem	NOUN
gs-4426	126	17	cells	cell	NOUN
gs-4426	126	18	protected	protect	VERB
gs-4426	126	19	from	from	ADP
gs-4426	126	20	immune	immune	ADJ
gs-4426	126	21	attack	attack	NOUN
gs-4426	126	22	by	by	ADP
gs-4426	126	23	semi	semi	ADJ
gs-4426	126	24	-	-	ADJ
gs-4426	126	25	permeable	permeable	ADJ
gs-4426	126	26	biocompatible	biocompatible	ADJ
gs-4426	126	27	membranes	membrane	NOUN
gs-4426	126	28	,	,	PUNCT
gs-4426	126	29	gene	gene	NOUN
gs-4426	126	30	editing	editing	NOUN
gs-4426	126	31	of	of	ADP
gs-4426	126	32	pancreatic	pancreatic	ADJ
gs-4426	126	33	progenitor	progenitor	NOUN
gs-4426	126	34	cells	cell	NOUN
gs-4426	126	35	to	to	PART
gs-4426	126	36	enhance	enhance	VERB
gs-4426	126	37	insulin	insulin	NOUN
gs-4426	126	38	production	production	NOUN
gs-4426	126	39	or	or	CCONJ
gs-4426	126	40	protect	protect	VERB
gs-4426	126	41	against	against	ADP
gs-4426	126	42	autoimmune	autoimmune	ADJ
gs-4426	126	43	destruction	destruction	NOUN
gs-4426	126	44	,	,	PUNCT
gs-4426	126	45	and	and	CCONJ
gs-4426	126	46	immunomodulatory	immunomodulatory	ADJ
gs-4426	126	47	gene	gene	NOUN
gs-4426	126	48	therapies	therapy	NOUN
gs-4426	126	49	aiming	aim	VERB
gs-4426	126	50	to	to	PART
gs-4426	126	51	induce	induce	VERB
gs-4426	126	52	immune	immune	ADJ
gs-4426	126	53	tolerance	tolerance	NOUN
gs-4426	126	54	and	and	CCONJ
gs-4426	126	55	prevent	prevent	VERB
gs-4426	126	56	beta	beta	ADJ
gs-4426	126	57	cell	cell	NOUN
gs-4426	126	58	destruction	destruction	NOUN
gs-4426	126	59	.	.	PUNCT
gs-4426	127	1	while	while	SCONJ
gs-4426	127	2	these	these	DET
gs-4426	127	3	approaches	approach	NOUN
gs-4426	127	4	remain	remain	VERB
gs-4426	127	5	in	in	ADP
gs-4426	127	6	relatively	relatively	ADV
gs-4426	127	7	early	early	ADJ
gs-4426	127	8	clinical	clinical	ADJ
gs-4426	127	9	development	development	NOUN
gs-4426	127	10	and	and	CCONJ
gs-4426	127	11	face	face	VERB
gs-4426	127	12	substantial	substantial	ADJ
gs-4426	127	13	technical	technical	ADJ
gs-4426	127	14	challenges	challenge	NOUN
gs-4426	127	15	including	include	VERB
gs-4426	127	16	ensuring	ensure	VERB
gs-4426	127	17	glucose	glucose	NOUN
gs-4426	127	18	-	-	PUNCT
gs-4426	127	19	responsive	responsive	ADJ
gs-4426	127	20	insulin	insulin	NOUN
gs-4426	127	21	secretion	secretion	NOUN
gs-4426	127	22	,	,	PUNCT
gs-4426	127	23	preventing	prevent	VERB
gs-4426	127	24	hypoglycemic	hypoglycemic	ADJ
gs-4426	127	25	episodes	episode	NOUN
gs-4426	127	26	,	,	PUNCT
gs-4426	127	27	and	and	CCONJ
gs-4426	127	28	overcoming	overcome	VERB
gs-4426	127	29	immune	immune	ADJ
gs-4426	127	30	rejection	rejection	NOUN
gs-4426	127	31	,	,	PUNCT
gs-4426	127	32	successful	successful	ADJ
gs-4426	127	33	development	development	NOUN
gs-4426	127	34	would	would	AUX
gs-4426	127	35	offer	offer	VERB
gs-4426	127	36	the	the	DET
gs-4426	127	37	possibility	possibility	NOUN
gs-4426	127	38	of	of	ADP
gs-4426	127	39	insulin	insulin	NOUN
gs-4426	127	40	independence	independence	NOUN
gs-4426	127	41	and	and	CCONJ
gs-4426	127	42	eliminate	eliminate	VERB
gs-4426	127	43	the	the	DET
gs-4426	127	44	burden	burden	NOUN
gs-4426	127	45	of	of	ADP
gs-4426	127	46	continuous	continuous	ADJ
gs-4426	127	47	glucose	glucose	NOUN
gs-4426	127	48	monitoring	monitoring	NOUN
gs-4426	127	49	and	and	CCONJ
gs-4426	127	50	multiple	multiple	ADJ
gs-4426	127	51	daily	daily	ADJ
gs-4426	127	52	insulin	insulin	NOUN
gs-4426	127	53	administrations	administration	NOUN
gs-4426	127	54	.	.	PUNCT
gs-4426	128	1	autoimmune	autoimmune	ADJ
gs-4426	128	2	disorders	disorder	NOUN
gs-4426	128	3	including	include	VERB
gs-4426	128	4	systemic	systemic	ADJ
gs-4426	128	5	lupus	lupus	PROPN
gs-4426	128	6	erythematosus	erythematosus	NOUN
gs-4426	128	7	,	,	PUNCT
gs-4426	128	8	rheumatoid	rheumatoid	NOUN
gs-4426	128	9	arthritis	arthritis	NOUN
gs-4426	128	10	,	,	PUNCT
gs-4426	128	11	and	and	CCONJ
gs-4426	128	12	myasthenia	myasthenia	NOUN
gs-4426	128	13	gravis	gravi	NOUN
gs-4426	128	14	have	have	AUX
gs-4426	128	15	emerged	emerge	VERB
gs-4426	128	16	as	as	ADP
gs-4426	128	17	promising	promise	VERB
gs-4426	128	18	targets	target	NOUN
gs-4426	128	19	for	for	ADP
gs-4426	128	20	car	car	NOUN
gs-4426	128	21	-	-	PUNCT
gs-4426	128	22	t	t	NOUN
gs-4426	128	23	cell	cell	NOUN
gs-4426	128	24	therapy	therapy	NOUN
gs-4426	128	25	adapted	adapt	VERB
gs-4426	128	26	from	from	ADP
gs-4426	128	27	oncology	oncology	NOUN
gs-4426	128	28	georgian	georgian	NOUN
gs-4426	128	29	scientists/	scientists/	NUM
gs-4426	128	30	.	.	PUNCT
gs-4426	129	1	7	7	NUM
gs-4426	129	2	n	n	DET
gs-4426	129	3	4	4	NUM
gs-4426	129	4	,	,	PUNCT
gs-4426	129	5	2025	2025	NUM
gs-4426	129	6	601	601	NUM
gs-4426	129	7	applications	application	NOUN
gs-4426	129	8	.	.	PUNCT
gs-4426	130	1	these	these	DET
gs-4426	130	2	diseases	disease	NOUN
gs-4426	130	3	involve	involve	VERB
gs-4426	130	4	autoreactive	autoreactive	ADJ
gs-4426	130	5	b	b	PROPN
gs-4426	130	6	cells	cell	NOUN
gs-4426	130	7	producing	produce	VERB
gs-4426	130	8	pathogenic	pathogenic	ADJ
gs-4426	130	9	autoantibodies	autoantibody	NOUN
gs-4426	130	10	that	that	PRON
gs-4426	130	11	drive	drive	VERB
gs-4426	130	12	tissue	tissue	NOUN
gs-4426	130	13	damage	damage	NOUN
gs-4426	130	14	and	and	CCONJ
gs-4426	130	15	clinical	clinical	ADJ
gs-4426	130	16	manifestations	manifestation	NOUN
gs-4426	130	17	.	.	PUNCT
gs-4426	131	1	car	car	NOUN
gs-4426	131	2	-	-	PUNCT
gs-4426	131	3	t	t	NOUN
gs-4426	131	4	cells	cell	NOUN
gs-4426	131	5	engineered	engineer	VERB
gs-4426	131	6	to	to	PART
gs-4426	131	7	target	target	VERB
gs-4426	131	8	cd19	cd19	PROPN
gs-4426	131	9	or	or	CCONJ
gs-4426	131	10	bcma	bcma	NOUN
gs-4426	131	11	,	,	PUNCT
gs-4426	131	12	antigens	antigen	NOUN
gs-4426	131	13	expressed	express	VERB
gs-4426	131	14	on	on	ADP
gs-4426	131	15	b	b	NOUN
gs-4426	131	16	-	-	PUNCT
gs-4426	131	17	lineage	lineage	NOUN
gs-4426	131	18	cells	cell	NOUN
gs-4426	131	19	,	,	PUNCT
gs-4426	131	20	can	can	AUX
gs-4426	131	21	eliminate	eliminate	VERB
gs-4426	131	22	autoreactive	autoreactive	ADJ
gs-4426	131	23	b	b	NOUN
gs-4426	131	24	-	-	PUNCT
gs-4426	131	25	cell	cell	NOUN
gs-4426	131	26	populations	population	NOUN
gs-4426	131	27	like	like	ADP
gs-4426	131	28	their	their	PRON
gs-4426	131	29	depletion	depletion	NOUN
gs-4426	131	30	of	of	ADP
gs-4426	131	31	malignant	malignant	ADJ
gs-4426	131	32	b	b	NOUN
gs-4426	131	33	cells	cell	NOUN
gs-4426	131	34	in	in	ADP
gs-4426	131	35	lymphoma	lymphoma	NOUN
gs-4426	131	36	treatment	treatment	NOUN
gs-4426	131	37	.	.	PUNCT
gs-4426	132	1	small	small	ADJ
gs-4426	132	2	early	early	ADJ
gs-4426	132	3	-	-	PUNCT
gs-4426	132	4	phase	phase	NOUN
gs-4426	132	5	clinical	clinical	ADJ
gs-4426	132	6	trials	trial	NOUN
gs-4426	132	7	evaluating	evaluate	VERB
gs-4426	132	8	car	car	NOUN
gs-4426	132	9	-	-	PUNCT
gs-4426	132	10	t	t	NOUN
gs-4426	132	11	therapy	therapy	NOUN
gs-4426	132	12	for	for	ADP
gs-4426	132	13	severe	severe	ADJ
gs-4426	132	14	refractory	refractory	NOUN
gs-4426	132	15	autoimmune	autoimmune	ADJ
gs-4426	132	16	diseases	disease	NOUN
gs-4426	132	17	have	have	AUX
gs-4426	132	18	demonstrated	demonstrate	VERB
gs-4426	132	19	remarkable	remarkable	ADJ
gs-4426	132	20	responses	response	NOUN
gs-4426	132	21	,	,	PUNCT
gs-4426	132	22	with	with	ADP
gs-4426	132	23	many	many	ADJ
gs-4426	132	24	patients	patient	NOUN
gs-4426	132	25	achieving	achieve	VERB
gs-4426	132	26	drug	drug	NOUN
gs-4426	132	27	-	-	PUNCT
gs-4426	132	28	free	free	ADJ
gs-4426	132	29	remissions	remission	NOUN
gs-4426	132	30	sustained	sustain	VERB
gs-4426	132	31	through	through	ADP
gs-4426	132	32	multi	multi	ADJ
gs-4426	132	33	-	-	ADJ
gs-4426	132	34	year	year	ADJ
gs-4426	132	35	followup	followup	NOUN
gs-4426	132	36	after	after	ADP
gs-4426	132	37	single	single	ADJ
gs-4426	132	38	car	car	NOUN
gs-4426	132	39	-	-	PUNCT
gs-4426	132	40	t	t	PROPN
gs-4426	132	41	cell	cell	NOUN
gs-4426	132	42	administration	administration	NOUN
gs-4426	132	43	.	.	PUNCT
gs-4426	133	1	these	these	DET
gs-4426	133	2	encouraging	encouraging	ADJ
gs-4426	133	3	preliminary	preliminary	ADJ
gs-4426	133	4	results	result	NOUN
gs-4426	133	5	have	have	AUX
gs-4426	133	6	motivated	motivate	VERB
gs-4426	133	7	larger	large	ADJ
gs-4426	133	8	controlled	control	VERB
gs-4426	133	9	trials	trial	NOUN
gs-4426	133	10	aimed	aim	VERB
gs-4426	133	11	at	at	ADP
gs-4426	133	12	defining	define	VERB
gs-4426	133	13	optimal	optimal	ADJ
gs-4426	133	14	patient	patient	ADJ
gs-4426	133	15	selection	selection	NOUN
gs-4426	133	16	criteria	criterion	NOUN
gs-4426	133	17	,	,	PUNCT
gs-4426	133	18	determining	determine	VERB
gs-4426	133	19	durability	durability	NOUN
gs-4426	133	20	of	of	ADP
gs-4426	133	21	responses	response	NOUN
gs-4426	133	22	,	,	PUNCT
gs-4426	133	23	and	and	CCONJ
gs-4426	133	24	assessing	assess	VERB
gs-4426	133	25	whether	whether	SCONJ
gs-4426	133	26	car	car	NOUN
gs-4426	133	27	-	-	PUNCT
gs-4426	133	28	t	t	NOUN
gs-4426	133	29	therapy	therapy	NOUN
gs-4426	133	30	could	could	AUX
gs-4426	133	31	replace	replace	VERB
gs-4426	133	32	or	or	CCONJ
gs-4426	133	33	substantially	substantially	ADV
gs-4426	133	34	reduce	reduce	VERB
gs-4426	133	35	the	the	DET
gs-4426	133	36	need	need	NOUN
gs-4426	133	37	for	for	ADP
gs-4426	133	38	chronic	chronic	ADJ
gs-4426	133	39	immunosuppressive	immunosuppressive	ADJ
gs-4426	133	40	medications	medication	NOUN
gs-4426	133	41	with	with	ADP
gs-4426	133	42	their	their	PRON
gs-4426	133	43	attendant	attendant	ADJ
gs-4426	133	44	toxicities	toxicity	NOUN
gs-4426	133	45	and	and	CCONJ
gs-4426	133	46	infection	infection	NOUN
gs-4426	133	47	risks	risk	NOUN
gs-4426	133	48	.	.	PUNCT
gs-4426	134	1	future	future	ADJ
gs-4426	134	2	directions	direction	NOUN
gs-4426	134	3	and	and	CCONJ
gs-4426	134	4	scope	scope	NOUN
gs-4426	134	5	of	of	ADP
gs-4426	134	6	this	this	DET
gs-4426	134	7	article	article	NOUN
gs-4426	134	8	the	the	DET
gs-4426	134	9	gene	gene	NOUN
gs-4426	134	10	therapy	therapy	NOUN
gs-4426	134	11	field	field	NOUN
gs-4426	134	12	stands	stand	VERB
gs-4426	134	13	at	at	ADP
gs-4426	134	14	an	an	DET
gs-4426	134	15	inflection	inflection	NOUN
gs-4426	134	16	point	point	NOUN
gs-4426	134	17	,	,	PUNCT
gs-4426	134	18	having	having	AUX
gs-4426	134	19	definitively	definitively	ADV
gs-4426	134	20	established	establish	VERB
gs-4426	134	21	clinical	clinical	ADJ
gs-4426	134	22	viability	viability	NOUN
gs-4426	134	23	and	and	CCONJ
gs-4426	134	24	therapeutic	therapeutic	ADJ
gs-4426	134	25	impact	impact	NOUN
gs-4426	134	26	while	while	SCONJ
gs-4426	134	27	facing	face	VERB
gs-4426	134	28	critical	critical	ADJ
gs-4426	134	29	challenges	challenge	NOUN
gs-4426	134	30	that	that	PRON
gs-4426	134	31	will	will	AUX
gs-4426	134	32	determine	determine	VERB
gs-4426	134	33	whether	whether	SCONJ
gs-4426	134	34	these	these	DET
gs-4426	134	35	interventions	intervention	NOUN
gs-4426	134	36	become	become	VERB
gs-4426	134	37	broadly	broadly	ADV
gs-4426	134	38	accessible	accessible	ADJ
gs-4426	134	39	treatments	treatment	NOUN
gs-4426	134	40	benefiting	benefit	VERB
gs-4426	134	41	large	large	ADJ
gs-4426	134	42	patient	patient	ADJ
gs-4426	134	43	populations	population	NOUN
gs-4426	134	44	or	or	CCONJ
gs-4426	134	45	remain	remain	VERB
gs-4426	134	46	niche	niche	NOUN
gs-4426	134	47	therapies	therapy	NOUN
gs-4426	134	48	available	available	ADJ
gs-4426	134	49	only	only	ADV
gs-4426	134	50	to	to	ADP
gs-4426	134	51	limited	limited	ADJ
gs-4426	134	52	numbers	number	NOUN
gs-4426	134	53	of	of	ADP
gs-4426	134	54	patients	patient	NOUN
gs-4426	134	55	with	with	ADP
gs-4426	134	56	rare	rare	ADJ
gs-4426	134	57	diseases	disease	NOUN
gs-4426	134	58	and	and	CCONJ
gs-4426	134	59	exceptional	exceptional	ADJ
gs-4426	134	60	financial	financial	ADJ
gs-4426	134	61	resources	resource	NOUN
gs-4426	134	62	.	.	PUNCT
gs-4426	135	1	projections	projection	NOUN
gs-4426	135	2	indicating	indicate	VERB
gs-4426	135	3	10	10	NUM
gs-4426	135	4	-	-	SYM
gs-4426	135	5	20	20	NUM
gs-4426	135	6	gene	gene	NOUN
gs-4426	135	7	therapy	therapy	NOUN
gs-4426	135	8	approvals	approval	NOUN
gs-4426	135	9	annually	annually	ADV
gs-4426	135	10	through	through	ADP
gs-4426	135	11	2025	2025	NUM
gs-4426	135	12	and	and	CCONJ
gs-4426	135	13	approximately	approximately	ADV
gs-4426	135	14	79	79	NUM
gs-4426	135	15	new	new	ADJ
gs-4426	135	16	durable	durable	ADJ
gs-4426	135	17	cell	cell	NOUN
gs-4426	135	18	and	and	CCONJ
gs-4426	135	19	gene	gene	NOUN
gs-4426	135	20	therapy	therapy	NOUN
gs-4426	135	21	approvals	approval	NOUN
gs-4426	135	22	expected	expect	VERB
gs-4426	135	23	by	by	ADP
gs-4426	135	24	2034	2034	NUM
gs-4426	135	25	suggest	suggest	VERB
gs-4426	135	26	a	a	DET
gs-4426	135	27	robust	robust	ADJ
gs-4426	135	28	clinical	clinical	ADJ
gs-4426	135	29	pipeline	pipeline	NOUN
gs-4426	135	30	poised	poise	VERB
gs-4426	135	31	to	to	PART
gs-4426	135	32	address	address	VERB
gs-4426	135	33	expanding	expand	VERB
gs-4426	135	34	disease	disease	NOUN
gs-4426	135	35	indications	indication	NOUN
gs-4426	135	36	.	.	PUNCT
gs-4426	136	1	however	however	ADV
gs-4426	136	2	,	,	PUNCT
gs-4426	136	3	realizing	realize	VERB
gs-4426	136	4	this	this	DET
gs-4426	136	5	potential	potential	NOUN
gs-4426	136	6	requires	require	VERB
gs-4426	136	7	addressing	address	VERB
gs-4426	136	8	manufacturing	manufacturing	NOUN
gs-4426	136	9	scalability	scalability	NOUN
gs-4426	136	10	,	,	PUNCT
gs-4426	136	11	developing	develop	VERB
gs-4426	136	12	sustainable	sustainable	ADJ
gs-4426	136	13	economic	economic	ADJ
gs-4426	136	14	models	model	NOUN
gs-4426	136	15	balancing	balance	VERB
gs-4426	136	16	incentives	incentive	NOUN
gs-4426	136	17	against	against	ADP
gs-4426	136	18	healthcare	healthcare	NOUN
gs-4426	136	19	affordability	affordability	NOUN
gs-4426	136	20	,	,	PUNCT
gs-4426	136	21	advancing	advance	VERB
gs-4426	136	22	delivery	delivery	NOUN
gs-4426	136	23	technologies	technology	NOUN
gs-4426	136	24	enabling	enable	VERB
gs-4426	136	25	previously	previously	ADV
gs-4426	136	26	inaccessible	inaccessible	ADJ
gs-4426	136	27	tissue	tissue	NOUN
gs-4426	136	28	targeting	target	VERB
gs-4426	136	29	,	,	PUNCT
gs-4426	136	30	and	and	CCONJ
gs-4426	136	31	refining	refining	NOUN
gs-4426	136	32	gene	gene	NOUN
gs-4426	136	33	editing	edit	VERB
gs-4426	136	34	precision	precision	NOUN
gs-4426	136	35	to	to	PART
gs-4426	136	36	minimize	minimize	VERB
gs-4426	136	37	off	off	ADP
gs-4426	136	38	-	-	PUNCT
gs-4426	136	39	target	target	NOUN
gs-4426	136	40	risks	risk	NOUN
gs-4426	136	41	while	while	SCONJ
gs-4426	136	42	maximizing	maximize	VERB
gs-4426	136	43	therapeutic	therapeutic	ADJ
gs-4426	136	44	benefit	benefit	NOUN
gs-4426	136	45	.	.	PUNCT
gs-4426	137	1	emerging	emerge	VERB
gs-4426	137	2	technologies	technology	NOUN
gs-4426	137	3	promise	promise	VERB
gs-4426	137	4	to	to	PART
gs-4426	137	5	overcome	overcome	VERB
gs-4426	137	6	current	current	ADJ
gs-4426	137	7	limitations	limitation	NOUN
gs-4426	137	8	and	and	CCONJ
gs-4426	137	9	enable	enable	VERB
gs-4426	137	10	next	next	ADJ
gs-4426	137	11	-	-	PUNCT
gs-4426	137	12	generation	generation	NOUN
gs-4426	137	13	gene	gene	NOUN
gs-4426	137	14	therapies	therapy	NOUN
gs-4426	137	15	with	with	ADP
gs-4426	137	16	enhanced	enhanced	ADJ
gs-4426	137	17	capabilities	capability	NOUN
gs-4426	137	18	.	.	PUNCT
gs-4426	138	1	base	base	NOUN
gs-4426	138	2	editors	editor	NOUN
gs-4426	138	3	and	and	CCONJ
gs-4426	138	4	prime	prime	ADJ
gs-4426	138	5	editors	editor	NOUN
gs-4426	138	6	,	,	PUNCT
gs-4426	138	7	which	which	PRON
gs-4426	138	8	enable	enable	VERB
gs-4426	138	9	precise	precise	ADJ
gs-4426	138	10	singlenucleotide	singlenucleotide	NOUN
gs-4426	138	11	changes	change	NOUN
gs-4426	138	12	or	or	CCONJ
gs-4426	138	13	small	small	ADJ
gs-4426	138	14	insertions	insertion	NOUN
gs-4426	138	15	/	/	SYM
gs-4426	138	16	deletions	deletion	NOUN
gs-4426	138	17	without	without	ADP
gs-4426	138	18	creating	create	VERB
gs-4426	138	19	double	double	ADJ
gs-4426	138	20	-	-	PUNCT
gs-4426	138	21	strand	strand	NOUN
gs-4426	138	22	breaks	break	NOUN
gs-4426	138	23	,	,	PUNCT
gs-4426	138	24	offer	offer	VERB
gs-4426	138	25	the	the	DET
gs-4426	138	26	potential	potential	NOUN
gs-4426	138	27	for	for	ADP
gs-4426	138	28	safer	safe	ADJ
gs-4426	138	29	and	and	CCONJ
gs-4426	138	30	more	more	ADV
gs-4426	138	31	precise	precise	ADJ
gs-4426	138	32	genome	genome	NOUN
gs-4426	138	33	editing	editing	NOUN
gs-4426	138	34	with	with	ADP
gs-4426	138	35	reduced	reduced	ADJ
gs-4426	138	36	risk	risk	NOUN
gs-4426	138	37	of	of	ADP
gs-4426	138	38	chromosomal	chromosomal	ADJ
gs-4426	138	39	rearrangements	rearrangement	NOUN
gs-4426	138	40	and	and	CCONJ
gs-4426	138	41	unintended	unintended	ADJ
gs-4426	138	42	large	large	ADJ
gs-4426	138	43	deletions	deletion	NOUN
gs-4426	138	44	(	(	PUNCT
gs-4426	138	45	davies	davy	NOUN
gs-4426	138	46	et	et	PROPN
gs-4426	138	47	al	al	PROPN
gs-4426	138	48	.	.	PROPN
gs-4426	138	49	,	,	PUNCT
gs-4426	138	50	2024	2024	NUM
gs-4426	138	51	)	)	PUNCT
gs-4426	138	52	.	.	PUNCT
gs-4426	139	1	novel	novel	ADJ
gs-4426	139	2	delivery	delivery	NOUN
gs-4426	139	3	systems	system	NOUN
gs-4426	139	4	including	include	VERB
gs-4426	139	5	engineered	engineer	VERB
gs-4426	139	6	virus	virus	NOUN
gs-4426	139	7	-	-	PUNCT
gs-4426	139	8	like	like	ADJ
gs-4426	139	9	particles	particle	NOUN
gs-4426	139	10	,	,	PUNCT
gs-4426	139	11	exosome	exosome	NOUN
gs-4426	139	12	-	-	PUNCT
gs-4426	139	13	based	base	VERB
gs-4426	139	14	vectors	vector	NOUN
gs-4426	139	15	,	,	PUNCT
gs-4426	139	16	and	and	CCONJ
gs-4426	139	17	synthetic	synthetic	ADJ
gs-4426	139	18	nanoparticles	nanoparticle	NOUN
gs-4426	139	19	with	with	ADP
gs-4426	139	20	tissue	tissue	NOUN
gs-4426	139	21	-	-	PUNCT
gs-4426	139	22	targeting	target	VERB
gs-4426	139	23	moieties	moiety	NOUN
gs-4426	139	24	aim	aim	VERB
gs-4426	139	25	to	to	PART
gs-4426	139	26	expand	expand	VERB
gs-4426	139	27	the	the	DET
gs-4426	139	28	range	range	NOUN
gs-4426	139	29	of	of	ADP
gs-4426	139	30	treatable	treatable	ADJ
gs-4426	139	31	tissues	tissue	NOUN
gs-4426	139	32	beyond	beyond	ADP
gs-4426	139	33	current	current	ADJ
gs-4426	139	34	capabilities	capability	NOUN
gs-4426	139	35	.	.	PUNCT
gs-4426	140	1	machine	machine	NOUN
gs-4426	140	2	learning	learn	VERB
gs-4426	140	3	approaches	approach	NOUN
gs-4426	140	4	applied	apply	VERB
gs-4426	140	5	to	to	ADP
gs-4426	140	6	capsid	capsid	ADJ
gs-4426	140	7	engineering	engineering	NOUN
gs-4426	140	8	,	,	PUNCT
gs-4426	140	9	guide	guide	VERB
gs-4426	140	10	rna	rna	NOUN
gs-4426	140	11	design	design	NOUN
gs-4426	140	12	,	,	PUNCT
gs-4426	140	13	and	and	CCONJ
gs-4426	140	14	prediction	prediction	NOUN
gs-4426	140	15	of	of	ADP
gs-4426	140	16	off	off	ADP
gs-4426	140	17	target	target	NOUN
gs-4426	140	18	editing	editing	NOUN
gs-4426	140	19	effects	effect	NOUN
gs-4426	140	20	may	may	AUX
gs-4426	140	21	accelerate	accelerate	VERB
gs-4426	140	22	development	development	NOUN
gs-4426	140	23	of	of	ADP
gs-4426	140	24	optimized	optimize	VERB
gs-4426	140	25	gene	gene	NOUN
gs-4426	140	26	therapy	therapy	NOUN
gs-4426	140	27	components	component	NOUN
gs-4426	140	28	.	.	PUNCT
gs-4426	141	1	multiplexed	multiplexed	ADJ
gs-4426	141	2	editing	edit	VERB
gs-4426	141	3	strategies	strategy	NOUN
gs-4426	141	4	targeting	target	VERB
gs-4426	141	5	multiple	multiple	ADJ
gs-4426	141	6	genes	gene	NOUN
gs-4426	141	7	simultaneously	simultaneously	ADV
gs-4426	141	8	could	could	AUX
gs-4426	141	9	address	address	VERB
gs-4426	141	10	polygenic	polygenic	ADJ
gs-4426	141	11	diseases	disease	NOUN
gs-4426	141	12	and	and	CCONJ
gs-4426	141	13	enhance	enhance	VERB
gs-4426	141	14	therapeutic	therapeutic	ADJ
gs-4426	141	15	efficacy	efficacy	NOUN
gs-4426	141	16	through	through	ADP
gs-4426	141	17	complementary	complementary	ADJ
gs-4426	141	18	mechanisms	mechanism	NOUN
gs-4426	141	19	.	.	PUNCT
gs-4426	142	1	this	this	DET
gs-4426	142	2	comprehensive	comprehensive	ADJ
gs-4426	142	3	article	article	NOUN
gs-4426	142	4	synthesizes	synthesize	VERB
gs-4426	142	5	current	current	ADJ
gs-4426	142	6	knowledge	knowledge	NOUN
gs-4426	142	7	regarding	regard	VERB
gs-4426	142	8	gene	gene	NOUN
gs-4426	142	9	therapy	therapy	NOUN
gs-4426	142	10	advances	advance	VERB
gs-4426	142	11	through	through	ADP
gs-4426	142	12	2025	2025	NUM
gs-4426	142	13	,	,	PUNCT
gs-4426	142	14	examining	examine	VERB
gs-4426	142	15	the	the	DET
gs-4426	142	16	full	full	ADJ
gs-4426	142	17	spectrum	spectrum	NOUN
gs-4426	142	18	of	of	ADP
gs-4426	142	19	therapeutic	therapeutic	ADJ
gs-4426	142	20	modalities	modality	NOUN
gs-4426	142	21	including	include	VERB
gs-4426	142	22	viral	viral	ADJ
gs-4426	142	23	vectors	vector	NOUN
gs-4426	142	24	,	,	PUNCT
gs-4426	142	25	crispr	crispr	NOUN
gs-4426	142	26	-	-	PUNCT
gs-4426	142	27	based	base	VERB
gs-4426	142	28	editing	editing	NOUN
gs-4426	142	29	,	,	PUNCT
gs-4426	142	30	car	car	NOUN
gs-4426	142	31	-	-	PUNCT
gs-4426	142	32	t	t	PROPN
gs-4426	142	33	and	and	CCONJ
gs-4426	142	34	other	other	ADJ
gs-4426	142	35	cell	cell	NOUN
gs-4426	142	36	therapies	therapy	NOUN
gs-4426	142	37	,	,	PUNCT
gs-4426	142	38	and	and	CCONJ
gs-4426	142	39	rna	rna	NOUN
gs-4426	142	40	-	-	PUNCT
gs-4426	142	41	based	base	VERB
gs-4426	142	42	approaches	approach	NOUN
gs-4426	142	43	.	.	PUNCT
gs-4426	143	1	we	we	PRON
gs-4426	143	2	analyze	analyze	VERB
gs-4426	143	3	clinical	clinical	ADJ
gs-4426	143	4	outcomes	outcome	NOUN
gs-4426	143	5	across	across	ADP
gs-4426	143	6	major	major	ADJ
gs-4426	143	7	disease	disease	NOUN
gs-4426	143	8	categories	category	NOUN
gs-4426	143	9	including	include	VERB
gs-4426	143	10	hematological	hematological	ADJ
gs-4426	143	11	disorders	disorder	NOUN
gs-4426	143	12	,	,	PUNCT
gs-4426	143	13	solid	solid	ADJ
gs-4426	143	14	tumors	tumor	NOUN
gs-4426	143	15	,	,	PUNCT
gs-4426	143	16	rare	rare	ADJ
gs-4426	143	17	genetic	genetic	ADJ
gs-4426	143	18	diseases	disease	NOUN
gs-4426	143	19	,	,	PUNCT
gs-4426	143	20	cardiovascular	cardiovascular	ADJ
gs-4426	143	21	conditions	condition	NOUN
gs-4426	143	22	,	,	PUNCT
gs-4426	143	23	diabetes	diabetes	NOUN
gs-4426	143	24	,	,	PUNCT
gs-4426	143	25	autoimmune	autoimmune	ADJ
gs-4426	143	26	disorders	disorder	NOUN
gs-4426	143	27	,	,	PUNCT
gs-4426	143	28	and	and	CCONJ
gs-4426	143	29	infectious	infectious	ADJ
gs-4426	143	30	diseases	disease	NOUN
gs-4426	143	31	,	,	PUNCT
gs-4426	143	32	evaluating	evaluate	VERB
gs-4426	143	33	efficacy	efficacy	NOUN
gs-4426	143	34	data	datum	NOUN
gs-4426	143	35	,	,	PUNCT
gs-4426	143	36	safety	safety	NOUN
gs-4426	143	37	profiles	profile	NOUN
gs-4426	143	38	,	,	PUNCT
gs-4426	143	39	and	and	CCONJ
gs-4426	143	40	factors	factor	NOUN
gs-4426	143	41	influencing	influence	VERB
gs-4426	143	42	treatment	treatment	NOUN
gs-4426	143	43	responses	response	NOUN
gs-4426	143	44	.	.	PUNCT
gs-4426	144	1	the	the	DET
gs-4426	144	2	regulatory	regulatory	ADJ
gs-4426	144	3	landscape	landscape	NOUN
gs-4426	144	4	receives	receive	VERB
gs-4426	144	5	detailed	detailed	ADJ
gs-4426	144	6	attention	attention	NOUN
gs-4426	144	7	,	,	PUNCT
gs-4426	144	8	including	include	VERB
gs-4426	144	9	approval	approval	NOUN
gs-4426	144	10	pathways	pathway	NOUN
gs-4426	144	11	,	,	PUNCT
gs-4426	144	12	post	post	ADJ
gs-4426	144	13	-	-	ADJ
gs-4426	144	14	marketing	marketing	ADJ
gs-4426	144	15	surveillance	surveillance	NOUN
gs-4426	144	16	requirements	requirement	NOUN
gs-4426	144	17	,	,	PUNCT
gs-4426	144	18	and	and	CCONJ
gs-4426	144	19	evolving	evolve	VERB
gs-4426	144	20	frameworks	framework	NOUN
gs-4426	144	21	accommodating	accommodate	VERB
gs-4426	144	22	platform	platform	NOUN
gs-4426	144	23	technologies	technology	NOUN
gs-4426	144	24	and	and	CCONJ
gs-4426	144	25	personalized	personalized	ADJ
gs-4426	144	26	therapies	therapy	NOUN
gs-4426	144	27	.	.	PUNCT
gs-4426	145	1	technical	technical	ADJ
gs-4426	145	2	innovations	innovation	NOUN
gs-4426	145	3	in	in	ADP
gs-4426	145	4	delivery	delivery	NOUN
gs-4426	145	5	systems	system	NOUN
gs-4426	145	6	,	,	PUNCT
gs-4426	145	7	gene	gene	NOUN
gs-4426	145	8	editing	editing	NOUN
gs-4426	145	9	tools	tool	NOUN
gs-4426	145	10	,	,	PUNCT
gs-4426	145	11	and	and	CCONJ
gs-4426	145	12	georgian	georgian	NOUN
gs-4426	145	13	scientists/	scientists/	NUM
gs-4426	145	14	.	.	PUNCT
gs-4426	146	1	7	7	NUM
gs-4426	146	2	n	n	DET
gs-4426	146	3	4	4	NUM
gs-4426	146	4	,	,	PUNCT
gs-4426	146	5	2025	2025	NUM
gs-4426	146	6	602	602	NUM
gs-4426	146	7	manufacturing	manufacturing	NOUN
gs-4426	146	8	processes	process	NOUN
gs-4426	146	9	are	be	AUX
gs-4426	146	10	examined	examine	VERB
gs-4426	146	11	with	with	ADP
gs-4426	146	12	emphasis	emphasis	NOUN
gs-4426	146	13	on	on	ADP
gs-4426	146	14	their	their	PRON
gs-4426	146	15	potential	potential	NOUN
gs-4426	146	16	to	to	PART
gs-4426	146	17	address	address	VERB
gs-4426	146	18	current	current	ADJ
gs-4426	146	19	limitations	limitation	NOUN
gs-4426	146	20	.	.	PUNCT
gs-4426	147	1	economic	economic	ADJ
gs-4426	147	2	and	and	CCONJ
gs-4426	147	3	access	access	NOUN
gs-4426	147	4	considerations	consideration	NOUN
gs-4426	147	5	receive	receive	VERB
gs-4426	147	6	critical	critical	ADJ
gs-4426	147	7	analysis	analysis	NOUN
gs-4426	147	8	,	,	PUNCT
gs-4426	147	9	including	include	VERB
gs-4426	147	10	pricing	pricing	NOUN
gs-4426	147	11	strategies	strategy	NOUN
gs-4426	147	12	,	,	PUNCT
gs-4426	147	13	reimbursement	reimbursement	NOUN
gs-4426	147	14	models	model	NOUN
gs-4426	147	15	,	,	PUNCT
gs-4426	147	16	and	and	CCONJ
gs-4426	147	17	approaches	approach	NOUN
gs-4426	147	18	to	to	ADP
gs-4426	147	19	enhancing	enhance	VERB
gs-4426	147	20	global	global	ADJ
gs-4426	147	21	accessibility	accessibility	NOUN
gs-4426	147	22	of	of	ADP
gs-4426	147	23	gene	gene	NOUN
gs-4426	147	24	therapy	therapy	NOUN
gs-4426	147	25	technologies	technology	NOUN
gs-4426	147	26	.	.	PUNCT
gs-4426	148	1	the	the	DET
gs-4426	148	2	article	article	NOUN
gs-4426	148	3	aims	aim	VERB
gs-4426	148	4	to	to	PART
gs-4426	148	5	provide	provide	VERB
gs-4426	148	6	researchers	researcher	NOUN
gs-4426	148	7	,	,	PUNCT
gs-4426	148	8	clinicians	clinician	NOUN
gs-4426	148	9	,	,	PUNCT
gs-4426	148	10	policymakers	policymaker	NOUN
gs-4426	148	11	,	,	PUNCT
gs-4426	148	12	and	and	CCONJ
gs-4426	148	13	industry	industry	NOUN
gs-4426	148	14	stakeholders	stakeholder	NOUN
gs-4426	148	15	with	with	ADP
gs-4426	148	16	comprehensive	comprehensive	ADJ
gs-4426	148	17	understanding	understanding	NOUN
gs-4426	148	18	of	of	ADP
gs-4426	148	19	gene	gene	NOUN
gs-4426	148	20	therapy	therapy	NOUN
gs-4426	148	21	's	's	PART
gs-4426	148	22	current	current	ADJ
gs-4426	148	23	state	state	NOUN
gs-4426	148	24	,	,	PUNCT
gs-4426	148	25	critical	critical	ADJ
gs-4426	148	26	assessment	assessment	NOUN
gs-4426	148	27	of	of	ADP
gs-4426	148	28	opportunities	opportunity	NOUN
gs-4426	148	29	and	and	CCONJ
gs-4426	148	30	challenges	challenge	NOUN
gs-4426	148	31	,	,	PUNCT
gs-4426	148	32	and	and	CCONJ
gs-4426	148	33	informed	inform	VERB
gs-4426	148	34	perspective	perspective	NOUN
gs-4426	148	35	on	on	ADP
gs-4426	148	36	future	future	ADJ
gs-4426	148	37	directions	direction	NOUN
gs-4426	148	38	.	.	PUNCT
gs-4426	149	1	by	by	ADP
gs-4426	149	2	synthesizing	synthesize	VERB
gs-4426	149	3	data	datum	NOUN
gs-4426	149	4	from	from	ADP
gs-4426	149	5	clinical	clinical	ADJ
gs-4426	149	6	trials	trial	NOUN
gs-4426	149	7	,	,	PUNCT
gs-4426	149	8	regulatory	regulatory	ADJ
gs-4426	149	9	filings	filing	NOUN
gs-4426	149	10	,	,	PUNCT
gs-4426	149	11	scientific	scientific	ADJ
gs-4426	149	12	literature	literature	NOUN
gs-4426	149	13	,	,	PUNCT
gs-4426	149	14	and	and	CCONJ
gs-4426	149	15	field	field	NOUN
gs-4426	149	16	expert	expert	NOUN
gs-4426	149	17	perspectives	perspective	NOUN
gs-4426	149	18	,	,	PUNCT
gs-4426	149	19	we	we	PRON
gs-4426	149	20	present	present	VERB
gs-4426	149	21	an	an	DET
gs-4426	149	22	integrated	integrated	ADJ
gs-4426	149	23	view	view	NOUN
gs-4426	149	24	of	of	ADP
gs-4426	149	25	this	this	PRON
gs-4426	149	26	rapidly	rapidly	ADV
gs-4426	149	27	evolving	evolve	VERB
gs-4426	149	28	therapeutic	therapeutic	ADJ
gs-4426	149	29	landscape	landscape	NOUN
gs-4426	149	30	.	.	PUNCT
gs-4426	150	1	particular	particular	ADJ
gs-4426	150	2	emphasis	emphasis	NOUN
gs-4426	150	3	is	be	AUX
gs-4426	150	4	placed	place	VERB
gs-4426	150	5	on	on	ADP
gs-4426	150	6	translational	translational	ADJ
gs-4426	150	7	aspects	aspect	NOUN
gs-4426	150	8	bridging	bridge	VERB
gs-4426	150	9	basic	basic	ADJ
gs-4426	150	10	research	research	NOUN
gs-4426	150	11	discoveries	discovery	NOUN
gs-4426	150	12	and	and	CCONJ
gs-4426	150	13	clinical	clinical	ADJ
gs-4426	150	14	implementation	implementation	NOUN
gs-4426	150	15	,	,	PUNCT
gs-4426	150	16	identifying	identify	VERB
gs-4426	150	17	knowledge	knowledge	NOUN
gs-4426	150	18	gaps	gap	NOUN
gs-4426	150	19	requiring	require	VERB
gs-4426	150	20	further	further	ADJ
gs-4426	150	21	investigation	investigation	NOUN
gs-4426	150	22	,	,	PUNCT
gs-4426	150	23	and	and	CCONJ
gs-4426	150	24	projecting	project	VERB
gs-4426	150	25	how	how	SCONJ
gs-4426	150	26	anticipated	anticipate	VERB
gs-4426	150	27	advances	advance	NOUN
gs-4426	150	28	may	may	AUX
gs-4426	150	29	reshape	reshape	VERB
gs-4426	150	30	treatment	treatment	NOUN
gs-4426	150	31	paradigms	paradigm	NOUN
gs-4426	150	32	across	across	ADP
gs-4426	150	33	diverse	diverse	ADJ
gs-4426	150	34	diseases	disease	NOUN
gs-4426	150	35	.	.	PUNCT
gs-4426	151	1	the	the	DET
gs-4426	151	2	goal	goal	NOUN
gs-4426	151	3	is	be	AUX
gs-4426	151	4	to	to	PART
gs-4426	151	5	facilitate	facilitate	VERB
gs-4426	151	6	continued	continued	ADJ
gs-4426	151	7	progress	progress	NOUN
gs-4426	151	8	in	in	ADP
gs-4426	151	9	developing	develop	VERB
gs-4426	151	10	gene	gene	NOUN
gs-4426	151	11	therapies	therapy	NOUN
gs-4426	151	12	that	that	PRON
gs-4426	151	13	fulfill	fulfill	VERB
gs-4426	151	14	the	the	DET
gs-4426	151	15	field	field	NOUN
gs-4426	151	16	's	's	PART
gs-4426	151	17	foundational	foundational	ADJ
gs-4426	151	18	promise	promise	NOUN
gs-4426	151	19	:	:	PUNCT
gs-4426	151	20	permanently	permanently	ADV
gs-4426	151	21	treating	treat	VERB
gs-4426	151	22	or	or	CCONJ
gs-4426	151	23	curing	cure	VERB
gs-4426	151	24	diseases	disease	NOUN
gs-4426	151	25	by	by	ADP
gs-4426	151	26	correcting	correct	VERB
gs-4426	151	27	their	their	PRON
gs-4426	151	28	underlying	underlying	ADJ
gs-4426	151	29	genetic	genetic	ADJ
gs-4426	151	30	causes	cause	NOUN
gs-4426	151	31	,	,	PUNCT
gs-4426	151	32	thereby	thereby	ADV
gs-4426	151	33	transforming	transform	VERB
gs-4426	151	34	patients	patient	NOUN
gs-4426	151	35	'	'	PART
gs-4426	151	36	lives	life	NOUN
gs-4426	151	37	and	and	CCONJ
gs-4426	151	38	fundamentally	fundamentally	ADV
gs-4426	151	39	changing	change	VERB
gs-4426	151	40	medical	medical	ADJ
gs-4426	151	41	practice	practice	NOUN
gs-4426	151	42	.	.	PUNCT
gs-4426	152	1	materials	material	NOUN
gs-4426	152	2	and	and	CCONJ
gs-4426	152	3	methods	method	NOUN
gs-4426	152	4	literature	literature	NOUN
gs-4426	152	5	search	search	NOUN
gs-4426	152	6	strategy	strategy	NOUN
gs-4426	152	7	a	a	DET
gs-4426	152	8	comprehensive	comprehensive	ADJ
gs-4426	152	9	literature	literature	NOUN
gs-4426	152	10	search	search	NOUN
gs-4426	152	11	was	be	AUX
gs-4426	152	12	conducted	conduct	VERB
gs-4426	152	13	to	to	PART
gs-4426	152	14	identify	identify	VERB
gs-4426	152	15	relevant	relevant	ADJ
gs-4426	152	16	publications	publication	NOUN
gs-4426	152	17	,	,	PUNCT
gs-4426	152	18	clinical	clinical	ADJ
gs-4426	152	19	trial	trial	NOUN
gs-4426	152	20	data	datum	NOUN
gs-4426	152	21	,	,	PUNCT
gs-4426	152	22	and	and	CCONJ
gs-4426	152	23	regulatory	regulatory	ADJ
gs-4426	152	24	information	information	NOUN
gs-4426	152	25	related	relate	VERB
gs-4426	152	26	to	to	ADP
gs-4426	152	27	gene	gene	NOUN
gs-4426	152	28	therapy	therapy	NOUN
gs-4426	152	29	advances	advance	VERB
gs-4426	152	30	from	from	ADP
gs-4426	152	31	january	january	PROPN
gs-4426	152	32	2023	2023	NUM
gs-4426	152	33	to	to	ADP
gs-4426	152	34	december	december	PROPN
gs-4426	152	35	2025	2025	NUM
gs-4426	152	36	.	.	PUNCT
gs-4426	153	1	multiple	multiple	ADJ
gs-4426	153	2	electronic	electronic	ADJ
gs-4426	153	3	databases	database	NOUN
gs-4426	153	4	and	and	CCONJ
gs-4426	153	5	information	information	NOUN
gs-4426	153	6	sources	source	NOUN
gs-4426	153	7	were	be	AUX
gs-4426	153	8	systematically	systematically	ADV
gs-4426	153	9	searched	search	VERB
gs-4426	153	10	to	to	PART
gs-4426	153	11	ensure	ensure	VERB
gs-4426	153	12	comprehensive	comprehensive	ADJ
gs-4426	153	13	coverage	coverage	NOUN
gs-4426	153	14	of	of	ADP
gs-4426	153	15	the	the	DET
gs-4426	153	16	current	current	ADJ
gs-4426	153	17	gene	gene	NOUN
gs-4426	153	18	therapy	therapy	NOUN
gs-4426	153	19	landscape	landscape	NOUN
gs-4426	153	20	.	.	PUNCT
gs-4426	154	1	database	database	NOUN
gs-4426	154	2	selection	selection	NOUN
gs-4426	154	3	the	the	DET
gs-4426	154	4	following	follow	VERB
gs-4426	154	5	databases	database	NOUN
gs-4426	154	6	and	and	CCONJ
gs-4426	154	7	resources	resource	NOUN
gs-4426	154	8	were	be	AUX
gs-4426	154	9	searched	search	VERB
gs-4426	154	10	:	:	PUNCT
gs-4426	154	11	pubmed	pubmed	PROPN
gs-4426	154	12	/	/	SYM
gs-4426	154	13	medline	medline	PROPN
gs-4426	154	14	:	:	PUNCT
gs-4426	154	15	for	for	ADP
gs-4426	154	16	peer	peer	NOUN
gs-4426	154	17	-	-	PUNCT
gs-4426	154	18	articleed	articleed	ADV
gs-4426	154	19	scientific	scientific	ADJ
gs-4426	154	20	literature	literature	NOUN
gs-4426	154	21	scopus	scopus	NOUN
gs-4426	154	22	:	:	PUNCT
gs-4426	154	23	for	for	ADP
gs-4426	154	24	multidisciplinary	multidisciplinary	ADJ
gs-4426	154	25	scientific	scientific	ADJ
gs-4426	154	26	publications	publication	NOUN
gs-4426	154	27	web	web	NOUN
gs-4426	154	28	of	of	ADP
gs-4426	154	29	science	science	NOUN
gs-4426	154	30	:	:	PUNCT
gs-4426	154	31	for	for	ADP
gs-4426	154	32	citation	citation	NOUN
gs-4426	154	33	tracking	tracking	NOUN
gs-4426	154	34	and	and	CCONJ
gs-4426	154	35	high	high	ADJ
gs-4426	154	36	-	-	PUNCT
gs-4426	154	37	impact	impact	NOUN
gs-4426	154	38	publications	publication	NOUN
gs-4426	154	39	clinicaltrials.gov	clinicaltrials.gov	NOUN
gs-4426	154	40	:	:	PUNCT
gs-4426	154	41	for	for	ADP
gs-4426	154	42	active	active	ADJ
gs-4426	154	43	and	and	CCONJ
gs-4426	154	44	completed	complete	VERB
gs-4426	154	45	clinical	clinical	ADJ
gs-4426	154	46	trial	trial	NOUN
gs-4426	154	47	registrations	registration	NOUN
gs-4426	154	48	european	european	ADJ
gs-4426	154	49	clinical	clinical	ADJ
gs-4426	154	50	trials	trial	NOUN
gs-4426	154	51	database	database	NOUN
gs-4426	154	52	(	(	PUNCT
gs-4426	154	53	eudract	eudract	NOUN
gs-4426	154	54	):	):	PUNCT
gs-4426	154	55	for	for	ADP
gs-4426	154	56	european	european	ADJ
gs-4426	154	57	clinical	clinical	ADJ
gs-4426	154	58	trial	trial	NOUN
gs-4426	154	59	information	information	NOUN
gs-4426	154	60	crispr	crispr	ADJ
gs-4426	154	61	medicine	medicine	PROPN
gs-4426	154	62	news	news	NOUN
gs-4426	154	63	database	database	NOUN
gs-4426	154	64	:	:	PUNCT
gs-4426	154	65	for	for	ADP
gs-4426	154	66	crispr	crispr	NOUN
gs-4426	154	67	-	-	PUNCT
gs-4426	154	68	specific	specific	ADJ
gs-4426	154	69	clinical	clinical	ADJ
gs-4426	154	70	trial	trial	NOUN
gs-4426	154	71	tracking	track	VERB
gs-4426	154	72	us	we	PRON
gs-4426	154	73	food	food	NOUN
gs-4426	154	74	and	and	CCONJ
gs-4426	154	75	drug	drug	PROPN
gs-4426	154	76	administration	administration	PROPN
gs-4426	154	77	(	(	PUNCT
gs-4426	154	78	fda	fda	PROPN
gs-4426	154	79	)	)	PUNCT
gs-4426	154	80	official	official	ADJ
gs-4426	154	81	website	website	NOUN
gs-4426	154	82	:	:	PUNCT
gs-4426	154	83	for	for	ADP
gs-4426	154	84	regulatory	regulatory	ADJ
gs-4426	154	85	approvals	approval	NOUN
gs-4426	154	86	and	and	CCONJ
gs-4426	154	87	safety	safety	NOUN
gs-4426	154	88	communications	communication	NOUN
gs-4426	154	89	european	european	PROPN
gs-4426	154	90	medicines	medicine	NOUN
gs-4426	154	91	agency	agency	NOUN
gs-4426	154	92	(	(	PUNCT
gs-4426	154	93	ema	ema	PROPN
gs-4426	154	94	)	)	PUNCT
gs-4426	154	95	website	website	NOUN
gs-4426	154	96	:	:	PUNCT
gs-4426	154	97	for	for	ADP
gs-4426	154	98	european	european	PROPN
gs-4426	154	99	regulatory	regulatory	ADJ
gs-4426	154	100	approvals	approval	NOUN
gs-4426	154	101	google	google	PROPN
gs-4426	154	102	scholar	scholar	NOUN
gs-4426	154	103	:	:	PUNCT
gs-4426	154	104	for	for	ADP
gs-4426	154	105	additional	additional	ADJ
gs-4426	154	106	academic	academic	ADJ
gs-4426	154	107	publications	publication	NOUN
gs-4426	154	108	and	and	CCONJ
gs-4426	154	109	preprints	preprint	NOUN
gs-4426	154	110	inclusion	inclusion	NOUN
gs-4426	154	111	and	and	CCONJ
gs-4426	154	112	exclusion	exclusion	NOUN
gs-4426	154	113	criteria	criterion	NOUN
gs-4426	154	114	inclusion	inclusion	NOUN
gs-4426	154	115	criteria	criterion	NOUN
gs-4426	154	116	:	:	PUNCT
gs-4426	154	117	publications	publication	NOUN
gs-4426	154	118	in	in	ADP
gs-4426	154	119	english	english	ADJ
gs-4426	154	120	language	language	NOUN
gs-4426	154	121	peer	peer	NOUN
gs-4426	154	122	-	-	PUNCT
gs-4426	154	123	articled	article	VERB
gs-4426	154	124	original	original	ADJ
gs-4426	154	125	research	research	NOUN
gs-4426	154	126	articles	article	NOUN
gs-4426	154	127	,	,	PUNCT
gs-4426	154	128	clinical	clinical	ADJ
gs-4426	154	129	trials	trial	NOUN
gs-4426	154	130	,	,	PUNCT
gs-4426	154	131	and	and	CCONJ
gs-4426	154	132	article	article	NOUN
gs-4426	154	133	articles	article	VERB
gs-4426	154	134	publications	publication	NOUN
gs-4426	154	135	from	from	ADP
gs-4426	154	136	january	january	PROPN
gs-4426	154	137	2018	2018	NUM
gs-4426	154	138	to	to	ADP
gs-4426	154	139	december	december	PROPN
gs-4426	154	140	2025	2025	NUM
gs-4426	154	141	studies	study	NOUN
gs-4426	154	142	reporting	report	VERB
gs-4426	154	143	clinical	clinical	ADJ
gs-4426	154	144	trial	trial	NOUN
gs-4426	154	145	results	result	NOUN
gs-4426	154	146	,	,	PUNCT
gs-4426	154	147	regulatory	regulatory	ADJ
gs-4426	154	148	approvals	approval	NOUN
gs-4426	154	149	,	,	PUNCT
gs-4426	154	150	or	or	CCONJ
gs-4426	154	151	significant	significant	ADJ
gs-4426	154	152	technological	technological	ADJ
gs-4426	154	153	advances	advance	NOUN
gs-4426	154	154	official	official	ADJ
gs-4426	154	155	regulatory	regulatory	ADJ
gs-4426	154	156	documents	document	NOUN
gs-4426	154	157	and	and	CCONJ
gs-4426	154	158	clinical	clinical	ADJ
gs-4426	154	159	trial	trial	NOUN
gs-4426	154	160	registrations	registration	NOUN
gs-4426	154	161	georgian	georgian	NOUN
gs-4426	154	162	scientists/	scientists/	NUM
gs-4426	154	163	.	.	PUNCT
gs-4426	155	1	7	7	NUM
gs-4426	155	2	n	n	DET
gs-4426	155	3	4	4	NUM
gs-4426	155	4	,	,	PUNCT
gs-4426	155	5	2025	2025	NUM
gs-4426	155	6	603	603	NUM
gs-4426	155	7	conference	conference	NOUN
gs-4426	155	8	abstracts	abstract	NOUN
gs-4426	155	9	from	from	ADP
gs-4426	155	10	major	major	ADJ
gs-4426	155	11	scientific	scientific	ADJ
gs-4426	155	12	meetings	meeting	NOUN
gs-4426	155	13	(	(	PUNCT
gs-4426	155	14	american	american	ADJ
gs-4426	155	15	society	society	NOUN
gs-4426	155	16	of	of	ADP
gs-4426	155	17	gene	gene	NOUN
gs-4426	155	18	and	and	CCONJ
gs-4426	155	19	cell	cell	NOUN
gs-4426	155	20	therapy	therapy	NOUN
gs-4426	155	21	,	,	PUNCT
gs-4426	155	22	european	european	ADJ
gs-4426	155	23	society	society	NOUN
gs-4426	155	24	of	of	ADP
gs-4426	155	25	gene	gene	NOUN
gs-4426	155	26	and	and	CCONJ
gs-4426	155	27	cell	cell	NOUN
gs-4426	155	28	therapy	therapy	NOUN
gs-4426	155	29	,	,	PUNCT
gs-4426	155	30	american	american	ADJ
gs-4426	155	31	society	society	NOUN
gs-4426	155	32	of	of	ADP
gs-4426	155	33	hematology	hematology	NOUN
gs-4426	155	34	)	)	PUNCT
gs-4426	155	35	exclusion	exclusion	NOUN
gs-4426	155	36	criteria	criterion	NOUN
gs-4426	155	37	:	:	PUNCT
gs-4426	155	38	publications	publication	NOUN
gs-4426	155	39	in	in	ADP
gs-4426	155	40	languages	language	NOUN
gs-4426	155	41	other	other	ADJ
gs-4426	155	42	than	than	ADP
gs-4426	155	43	english	english	PROPN
gs-4426	155	44	without	without	ADP
gs-4426	155	45	available	available	ADJ
gs-4426	155	46	translations	translation	NOUN
gs-4426	155	47	preclinical	preclinical	ADJ
gs-4426	155	48	studies	study	NOUN
gs-4426	155	49	without	without	ADP
gs-4426	155	50	direct	direct	ADJ
gs-4426	155	51	clinical	clinical	ADJ
gs-4426	155	52	relevance	relevance	NOUN
gs-4426	155	53	opinion	opinion	NOUN
gs-4426	155	54	pieces	piece	NOUN
gs-4426	155	55	,	,	PUNCT
gs-4426	155	56	editorials	editorial	NOUN
gs-4426	155	57	,	,	PUNCT
gs-4426	155	58	and	and	CCONJ
gs-4426	155	59	commentaries	commentary	NOUN
gs-4426	155	60	without	without	ADP
gs-4426	155	61	original	original	ADJ
gs-4426	155	62	data	datum	NOUN
gs-4426	155	63	(	(	PUNCT
gs-4426	155	64	unless	unless	SCONJ
gs-4426	155	65	from	from	ADP
gs-4426	155	66	recognized	recognize	VERB
gs-4426	155	67	thought	thought	NOUN
gs-4426	155	68	leaders	leader	NOUN
gs-4426	155	69	providing	provide	VERB
gs-4426	155	70	field	field	NOUN
gs-4426	155	71	perspective	perspective	NOUN
gs-4426	155	72	)	)	PUNCT
gs-4426	155	73	duplicate	duplicate	ADJ
gs-4426	155	74	publications	publication	NOUN
gs-4426	155	75	of	of	ADP
gs-4426	155	76	the	the	DET
gs-4426	155	77	same	same	ADJ
gs-4426	155	78	data	datum	NOUN
gs-4426	155	79	retracted	retract	VERB
gs-4426	155	80	articles	article	NOUN
gs-4426	155	81	publications	publication	NOUN
gs-4426	155	82	focused	focus	VERB
gs-4426	155	83	solely	solely	ADV
gs-4426	155	84	on	on	ADP
gs-4426	155	85	basic	basic	ADJ
gs-4426	155	86	mechanisms	mechanism	NOUN
gs-4426	155	87	without	without	ADP
gs-4426	155	88	translational	translational	ADJ
gs-4426	155	89	relevance	relevance	NOUN
gs-4426	155	90	quality	quality	NOUN
gs-4426	155	91	assessment	assessment	NOUN
gs-4426	155	92	the	the	DET
gs-4426	155	93	quality	quality	NOUN
gs-4426	155	94	of	of	ADP
gs-4426	155	95	included	include	VERB
gs-4426	155	96	clinical	clinical	ADJ
gs-4426	155	97	studies	study	NOUN
gs-4426	155	98	was	be	AUX
gs-4426	155	99	assessed	assess	VERB
gs-4426	155	100	using	use	VERB
gs-4426	155	101	appropriate	appropriate	ADJ
gs-4426	155	102	tools	tool	NOUN
gs-4426	155	103	:	:	PUNCT
gs-4426	155	104	randomized	randomize	VERB
gs-4426	155	105	controlled	control	VERB
gs-4426	155	106	trials	trial	NOUN
gs-4426	155	107	:	:	PUNCT
gs-4426	155	108	cochrane	cochrane	NOUN
gs-4426	155	109	risk	risk	NOUN
gs-4426	155	110	of	of	ADP
gs-4426	155	111	bias	bias	NOUN
gs-4426	155	112	tool	tool	NOUN
gs-4426	155	113	2.0	2.0	NUM
gs-4426	155	114	non	non	ADJ
gs-4426	155	115	-	-	ADJ
gs-4426	155	116	randomized	randomized	ADJ
gs-4426	155	117	studies	study	NOUN
gs-4426	155	118	:	:	PUNCT
gs-4426	155	119	robins	robin	NOUN
gs-4426	155	120	-	-	PUNCT
gs-4426	155	121	i	i	PRON
gs-4426	155	122	(	(	PUNCT
gs-4426	155	123	risk	risk	NOUN
gs-4426	155	124	of	of	ADP
gs-4426	155	125	bias	bias	NOUN
gs-4426	155	126	in	in	ADP
gs-4426	155	127	non	non	ADJ
gs-4426	155	128	-	-	ADJ
gs-4426	155	129	randomized	randomized	ADJ
gs-4426	155	130	studies	study	NOUN
gs-4426	155	131	of	of	ADP
gs-4426	155	132	interventions	intervention	NOUN
gs-4426	155	133	)	)	PUNCT
gs-4426	155	134	single	single	ADJ
gs-4426	155	135	-	-	PUNCT
gs-4426	155	136	arm	arm	NOUN
gs-4426	155	137	trials	trial	NOUN
gs-4426	155	138	:	:	PUNCT
gs-4426	155	139	assessment	assessment	NOUN
gs-4426	155	140	of	of	ADP
gs-4426	155	141	adequate	adequate	ADJ
gs-4426	155	142	outcome	outcome	NOUN
gs-4426	155	143	definition	definition	NOUN
gs-4426	155	144	,	,	PUNCT
gs-4426	155	145	follow	follow	VERB
gs-4426	155	146	-	-	PUNCT
gs-4426	155	147	up	up	ADP
gs-4426	155	148	duration	duration	NOUN
gs-4426	155	149	,	,	PUNCT
gs-4426	155	150	and	and	CCONJ
gs-4426	155	151	loss	loss	NOUN
gs-4426	155	152	to	to	PART
gs-4426	155	153	follow	follow	VERB
gs-4426	155	154	-	-	PUNCT
gs-4426	155	155	up	up	ADP
gs-4426	155	156	case	case	NOUN
gs-4426	155	157	reports	report	NOUN
gs-4426	155	158	/	/	SYM
gs-4426	155	159	series	series	NOUN
gs-4426	155	160	:	:	PUNCT
gs-4426	156	1	level	level	NOUN
gs-4426	156	2	of	of	ADP
gs-4426	156	3	evidence	evidence	NOUN
gs-4426	156	4	assessment	assessment	NOUN
gs-4426	156	5	according	accord	VERB
gs-4426	156	6	to	to	ADP
gs-4426	156	7	oxford	oxford	PROPN
gs-4426	156	8	centre	centre	NOUN
gs-4426	156	9	for	for	ADP
gs-4426	156	10	evidencebased	evidencebased	ADJ
gs-4426	156	11	medicine	medicine	NOUN
gs-4426	156	12	criteria	criterion	NOUN
gs-4426	156	13	article	article	NOUN
gs-4426	156	14	articles	article	NOUN
gs-4426	156	15	were	be	AUX
gs-4426	156	16	evaluated	evaluate	VERB
gs-4426	156	17	based	base	VERB
gs-4426	156	18	on	on	ADP
gs-4426	156	19	:	:	PUNCT
gs-4426	156	20	comprehensiveness	comprehensiveness	NOUN
gs-4426	156	21	of	of	ADP
gs-4426	156	22	literature	literature	NOUN
gs-4426	156	23	search	search	NOUN
gs-4426	156	24	transparency	transparency	NOUN
gs-4426	156	25	of	of	ADP
gs-4426	156	26	methodology	methodology	NOUN
gs-4426	156	27	appropriate	appropriate	ADJ
gs-4426	156	28	synthesis	synthesis	NOUN
gs-4426	156	29	and	and	CCONJ
gs-4426	156	30	interpretation	interpretation	NOUN
gs-4426	156	31	author	author	NOUN
gs-4426	156	32	expertise	expertise	NOUN
gs-4426	156	33	and	and	CCONJ
gs-4426	156	34	potential	potential	ADJ
gs-4426	156	35	conflicts	conflict	NOUN
gs-4426	156	36	of	of	ADP
gs-4426	156	37	interest	interest	NOUN
gs-4426	156	38	journal	journal	PROPN
gs-4426	156	39	impact	impact	NOUN
gs-4426	156	40	factor	factor	NOUN
gs-4426	156	41	and	and	CCONJ
gs-4426	156	42	peer	peer	NOUN
gs-4426	156	43	-	-	PUNCT
gs-4426	156	44	article	article	NOUN
gs-4426	156	45	process	process	NOUN
gs-4426	156	46	data	datum	NOUN
gs-4426	156	47	synthesis	synthesis	NOUN
gs-4426	156	48	and	and	CCONJ
gs-4426	156	49	analysis	analysis	NOUN
gs-4426	156	50	categorization	categorization	NOUN
gs-4426	156	51	framework	framework	NOUN
gs-4426	156	52	extracted	extract	VERB
gs-4426	156	53	data	datum	NOUN
gs-4426	156	54	were	be	AUX
gs-4426	156	55	organized	organize	VERB
gs-4426	156	56	into	into	ADP
gs-4426	156	57	thematic	thematic	ADJ
gs-4426	156	58	categories	category	NOUN
gs-4426	156	59	:	:	PUNCT
gs-4426	156	60	gene	gene	NOUN
gs-4426	156	61	therapy	therapy	NOUN
gs-4426	156	62	modalities	modality	NOUN
gs-4426	156	63	:	:	PUNCT
gs-4426	156	64	viral	viral	ADJ
gs-4426	156	65	vector	vector	NOUN
gs-4426	156	66	-	-	PUNCT
gs-4426	156	67	based	base	VERB
gs-4426	156	68	(	(	PUNCT
gs-4426	156	69	aav	aav	PROPN
gs-4426	156	70	,	,	PUNCT
gs-4426	156	71	lentivirus	lentivirus	NOUN
gs-4426	156	72	)	)	PUNCT
gs-4426	156	73	,	,	PUNCT
gs-4426	156	74	crispr	crispr	NOUN
gs-4426	156	75	-	-	PUNCT
gs-4426	156	76	based	base	VERB
gs-4426	156	77	editing	editing	NOUN
gs-4426	156	78	,	,	PUNCT
gs-4426	156	79	car	car	NOUN
gs-4426	156	80	-	-	PUNCT
gs-4426	156	81	t	t	NOUN
gs-4426	156	82	and	and	CCONJ
gs-4426	156	83	cell	cell	NOUN
gs-4426	156	84	therapies	therapy	NOUN
gs-4426	156	85	,	,	PUNCT
gs-4426	156	86	rna	rna	NOUN
gs-4426	156	87	therapeutics	therapeutic	NOUN
gs-4426	156	88	disease	disease	NOUN
gs-4426	156	89	areas	area	NOUN
gs-4426	156	90	:	:	PUNCT
gs-4426	156	91	blood	blood	NOUN
gs-4426	156	92	disorders	disorder	NOUN
gs-4426	156	93	,	,	PUNCT
gs-4426	156	94	cardiovascular	cardiovascular	ADJ
gs-4426	156	95	disease	disease	NOUN
gs-4426	156	96	,	,	PUNCT
gs-4426	156	97	cancer	cancer	NOUN
gs-4426	156	98	,	,	PUNCT
gs-4426	156	99	rare	rare	ADJ
gs-4426	156	100	genetic	genetic	ADJ
gs-4426	156	101	diseases	disease	NOUN
gs-4426	156	102	,	,	PUNCT
gs-4426	156	103	diabetes	diabete	NOUN
gs-4426	156	104	,	,	PUNCT
gs-4426	156	105	infectious	infectious	ADJ
gs-4426	156	106	diseases	disease	NOUN
gs-4426	156	107	,	,	PUNCT
gs-4426	156	108	autoimmune	autoimmune	ADJ
gs-4426	156	109	disorders	disorder	NOUN
gs-4426	156	110	development	development	NOUN
gs-4426	156	111	stage	stage	NOUN
gs-4426	156	112	:	:	PUNCT
gs-4426	156	113	preclinical	preclinical	ADJ
gs-4426	156	114	,	,	PUNCT
gs-4426	156	115	phase	phase	NOUN
gs-4426	156	116	i	i	PRON
gs-4426	156	117	,	,	PUNCT
gs-4426	156	118	phase	phase	NOUN
gs-4426	156	119	ii	ii	NOUN
gs-4426	156	120	,	,	PUNCT
gs-4426	156	121	phase	phase	NOUN
gs-4426	156	122	iii	iii	NOUN
gs-4426	156	123	,	,	PUNCT
gs-4426	156	124	regulatory	regulatory	ADJ
gs-4426	156	125	article	article	NOUN
gs-4426	156	126	,	,	PUNCT
gs-4426	156	127	approved	approve	VERB
gs-4426	156	128	geographic	geographic	ADJ
gs-4426	156	129	distribution	distribution	NOUN
gs-4426	156	130	:	:	PUNCT
gs-4426	156	131	north	north	PROPN
gs-4426	156	132	america	america	PROPN
gs-4426	156	133	,	,	PUNCT
gs-4426	156	134	europe	europe	PROPN
gs-4426	156	135	,	,	PUNCT
gs-4426	156	136	asia	asia	PROPN
gs-4426	156	137	-	-	PUNCT
gs-4426	156	138	pacific	pacific	PROPN
gs-4426	156	139	,	,	PUNCT
gs-4426	156	140	other	other	ADJ
gs-4426	156	141	regions	region	NOUN
gs-4426	156	142	quantitative	quantitative	ADJ
gs-4426	156	143	analysis	analysis	NOUN
gs-4426	156	144	descriptive	descriptive	ADJ
gs-4426	156	145	statistics	statistic	NOUN
gs-4426	156	146	were	be	AUX
gs-4426	156	147	calculated	calculate	VERB
gs-4426	156	148	for	for	ADP
gs-4426	156	149	:	:	PUNCT
gs-4426	156	150	number	number	NOUN
gs-4426	156	151	of	of	ADP
gs-4426	156	152	clinical	clinical	ADJ
gs-4426	156	153	trials	trial	NOUN
gs-4426	156	154	by	by	ADP
gs-4426	156	155	modality	modality	NOUN
gs-4426	156	156	,	,	PUNCT
gs-4426	156	157	disease	disease	NOUN
gs-4426	156	158	area	area	NOUN
gs-4426	156	159	,	,	PUNCT
gs-4426	156	160	and	and	CCONJ
gs-4426	156	161	phase	phase	NOUN
gs-4426	156	162	number	number	NOUN
gs-4426	156	163	of	of	ADP
gs-4426	156	164	regulatory	regulatory	ADJ
gs-4426	156	165	approvals	approval	NOUN
gs-4426	156	166	by	by	ADP
gs-4426	156	167	year	year	NOUN
gs-4426	156	168	,	,	PUNCT
gs-4426	156	169	region	region	NOUN
gs-4426	156	170	,	,	PUNCT
gs-4426	156	171	and	and	CCONJ
gs-4426	156	172	therapeutic	therapeutic	ADJ
gs-4426	156	173	category	category	NOUN
gs-4426	156	174	patient	patient	NOUN
gs-4426	156	175	enrollment	enrollment	NOUN
gs-4426	156	176	numbers	number	NOUN
gs-4426	156	177	across	across	ADP
gs-4426	156	178	different	different	ADJ
gs-4426	156	179	trial	trial	NOUN
gs-4426	156	180	types	type	NOUN
gs-4426	156	181	timeline	timeline	NOUN
gs-4426	156	182	metrics	metric	NOUN
gs-4426	156	183	(	(	PUNCT
gs-4426	156	184	approval	approval	NOUN
gs-4426	156	185	timelines	timeline	NOUN
gs-4426	156	186	,	,	PUNCT
gs-4426	156	187	development	development	NOUN
gs-4426	156	188	durations	duration	NOUN
gs-4426	156	189	)	)	PUNCT
gs-4426	156	190	trend	trend	NOUN
gs-4426	156	191	analysis	analysis	NOUN
gs-4426	156	192	was	be	AUX
gs-4426	156	193	performed	perform	VERB
gs-4426	156	194	to	to	PART
gs-4426	156	195	identify	identify	VERB
gs-4426	156	196	:	:	PUNCT
gs-4426	156	197	georgian	georgian	PROPN
gs-4426	156	198	scientists/	scientists/	NUM
gs-4426	156	199	.	.	PUNCT
gs-4426	157	1	7	7	NUM
gs-4426	157	2	n	n	DET
gs-4426	157	3	4	4	NUM
gs-4426	157	4	,	,	PUNCT
gs-4426	157	5	2025	2025	NUM
gs-4426	157	6	604	604	NUM
gs-4426	157	7	changes	change	NOUN
gs-4426	157	8	in	in	ADP
gs-4426	157	9	clinical	clinical	ADJ
gs-4426	157	10	trial	trial	NOUN
gs-4426	157	11	initiation	initiation	NOUN
gs-4426	157	12	rates	rate	NOUN
gs-4426	157	13	over	over	ADP
gs-4426	157	14	time	time	NOUN
gs-4426	157	15	shifts	shift	NOUN
gs-4426	157	16	in	in	ADP
gs-4426	157	17	disease	disease	NOUN
gs-4426	157	18	focus	focus	NOUN
gs-4426	157	19	(	(	PUNCT
gs-4426	157	20	oncology	oncology	NOUN
gs-4426	157	21	vs.	vs.	ADP
gs-4426	157	22	non	non	ADJ
gs-4426	157	23	-	-	ADJ
gs-4426	157	24	oncology	oncology	ADJ
gs-4426	157	25	)	)	PUNCT
gs-4426	157	26	evolution	evolution	NOUN
gs-4426	157	27	of	of	ADP
gs-4426	157	28	technology	technology	NOUN
gs-4426	157	29	platforms	platform	NOUN
gs-4426	157	30	geographic	geographic	ADJ
gs-4426	157	31	distribution	distribution	NOUN
gs-4426	157	32	changes	change	NOUN
gs-4426	157	33	qualitative	qualitative	VERB
gs-4426	157	34	synthesis	synthesis	NOUN
gs-4426	157	35	narrative	narrative	NOUN
gs-4426	157	36	synthesis	synthesis	NOUN
gs-4426	157	37	was	be	AUX
gs-4426	157	38	employed	employ	VERB
gs-4426	157	39	to	to	PART
gs-4426	157	40	:	:	PUNCT
gs-4426	157	41	describe	describe	VERB
gs-4426	157	42	technological	technological	ADJ
gs-4426	157	43	innovations	innovation	NOUN
gs-4426	157	44	and	and	CCONJ
gs-4426	157	45	their	their	PRON
gs-4426	157	46	potential	potential	ADJ
gs-4426	157	47	impact	impact	NOUN
gs-4426	157	48	discuss	discuss	VERB
gs-4426	157	49	clinical	clinical	ADJ
gs-4426	157	50	outcomes	outcome	NOUN
gs-4426	157	51	and	and	CCONJ
gs-4426	157	52	their	their	PRON
gs-4426	157	53	interpretation	interpretation	NOUN
gs-4426	157	54	identify	identify	VERB
gs-4426	157	55	patterns	pattern	NOUN
gs-4426	157	56	across	across	ADP
gs-4426	157	57	multiple	multiple	ADJ
gs-4426	157	58	studies	study	NOUN
gs-4426	157	59	highlight	highlight	VERB
gs-4426	157	60	areas	area	NOUN
gs-4426	157	61	of	of	ADP
gs-4426	157	62	consensus	consensus	NOUN
gs-4426	157	63	and	and	CCONJ
gs-4426	157	64	controversy	controversy	NOUN
gs-4426	157	65	contextualize	contextualize	VERB
gs-4426	157	66	findings	finding	NOUN
gs-4426	157	67	within	within	ADP
gs-4426	157	68	the	the	DET
gs-4426	157	69	broader	broad	ADJ
gs-4426	157	70	gene	gene	NOUN
gs-4426	157	71	therapy	therapy	NOUN
gs-4426	157	72	landscape	landscape	NOUN
gs-4426	157	73	thematic	thematic	ADJ
gs-4426	157	74	analysis	analysis	NOUN
gs-4426	157	75	was	be	AUX
gs-4426	157	76	used	use	VERB
gs-4426	157	77	to	to	PART
gs-4426	157	78	identify	identify	VERB
gs-4426	157	79	:	:	PUNCT
gs-4426	157	80	emerging	emerge	VERB
gs-4426	157	81	trends	trend	NOUN
gs-4426	157	82	in	in	ADP
gs-4426	157	83	gene	gene	NOUN
gs-4426	157	84	therapy	therapy	NOUN
gs-4426	157	85	development	development	NOUN
gs-4426	157	86	common	common	ADJ
gs-4426	157	87	challenges	challenge	NOUN
gs-4426	157	88	and	and	CCONJ
gs-4426	157	89	barriers	barrier	VERB
gs-4426	157	90	successful	successful	ADJ
gs-4426	157	91	strategies	strategy	NOUN
gs-4426	157	92	and	and	CCONJ
gs-4426	157	93	best	good	ADJ
gs-4426	157	94	practices	practice	NOUN
gs-4426	157	95	future	future	ADJ
gs-4426	157	96	directions	direction	NOUN
gs-4426	157	97	and	and	CCONJ
gs-4426	157	98	opportunities	opportunity	NOUN
gs-4426	157	99	regulatory	regulatory	ADJ
gs-4426	157	100	and	and	CCONJ
gs-4426	157	101	industry	industry	NOUN
gs-4426	157	102	information	information	NOUN
gs-4426	157	103	sources	source	NOUN
gs-4426	157	104	regulatory	regulatory	ADJ
gs-4426	157	105	databases	database	NOUN
gs-4426	157	106	official	official	ADJ
gs-4426	157	107	regulatory	regulatory	ADJ
gs-4426	157	108	information	information	NOUN
gs-4426	157	109	was	be	AUX
gs-4426	157	110	obtained	obtain	VERB
gs-4426	157	111	from	from	ADP
gs-4426	157	112	:	:	PUNCT
gs-4426	157	113	fda	fda	PROPN
gs-4426	157	114	center	center	PROPN
gs-4426	157	115	for	for	ADP
gs-4426	157	116	biologics	biologic	NOUN
gs-4426	157	117	evaluation	evaluation	NOUN
gs-4426	157	118	and	and	CCONJ
gs-4426	157	119	research	research	NOUN
gs-4426	157	120	(	(	PUNCT
gs-4426	157	121	cber	cber	PROPN
gs-4426	157	122	):	):	PUNCT
gs-4426	157	123	approved	approve	VERB
gs-4426	157	124	cellular	cellular	ADJ
gs-4426	157	125	and	and	CCONJ
gs-4426	157	126	gene	gene	NOUN
gs-4426	157	127	therapy	therapy	NOUN
gs-4426	157	128	products	product	NOUN
gs-4426	157	129	list	list	NOUN
gs-4426	157	130	,	,	PUNCT
gs-4426	157	131	biological	biological	ADJ
gs-4426	157	132	license	license	NOUN
gs-4426	157	133	applications	application	NOUN
gs-4426	157	134	(	(	PUNCT
gs-4426	157	135	bla	bla	NOUN
gs-4426	157	136	)	)	PUNCT
gs-4426	157	137	approval	approval	NOUN
gs-4426	157	138	letters	letter	NOUN
gs-4426	157	139	,	,	PUNCT
gs-4426	157	140	safety	safety	NOUN
gs-4426	157	141	communications	communication	NOUN
gs-4426	157	142	european	european	PROPN
gs-4426	157	143	medicines	medicine	NOUN
gs-4426	157	144	agency	agency	NOUN
gs-4426	157	145	(	(	PUNCT
gs-4426	157	146	ema	ema	PROPN
gs-4426	157	147	):	):	PUNCT
gs-4426	157	148	committee	committee	NOUN
gs-4426	157	149	for	for	ADP
gs-4426	157	150	advanced	advanced	ADJ
gs-4426	157	151	therapies	therapy	NOUN
gs-4426	157	152	reports	report	NOUN
gs-4426	157	153	,	,	PUNCT
gs-4426	157	154	marketing	marketing	NOUN
gs-4426	157	155	authorization	authorization	NOUN
gs-4426	157	156	documents	document	NOUN
gs-4426	157	157	national	national	ADJ
gs-4426	157	158	medical	medical	ADJ
gs-4426	157	159	products	product	NOUN
gs-4426	157	160	administration	administration	PROPN
gs-4426	157	161	(	(	PUNCT
gs-4426	157	162	nmpa	nmpa	PROPN
gs-4426	157	163	,	,	PUNCT
gs-4426	157	164	china	china	PROPN
gs-4426	157	165	):	):	PUNCT
gs-4426	157	166	approval	approval	NOUN
gs-4426	157	167	announcements	announcement	NOUN
gs-4426	157	168	and	and	CCONJ
gs-4426	157	169	clinical	clinical	ADJ
gs-4426	157	170	trial	trial	NOUN
gs-4426	157	171	authorizations	authorization	NOUN
gs-4426	157	172	pharmaceuticals	pharmaceutical	NOUN
gs-4426	157	173	and	and	CCONJ
gs-4426	157	174	medical	medical	ADJ
gs-4426	157	175	devices	device	NOUN
gs-4426	157	176	agency	agency	PROPN
gs-4426	157	177	(	(	PUNCT
gs-4426	157	178	pmda	pmda	PROPN
gs-4426	157	179	,	,	PUNCT
gs-4426	157	180	japan	japan	PROPN
gs-4426	157	181	):	):	PUNCT
gs-4426	157	182	approval	approval	NOUN
gs-4426	157	183	information	information	NOUN
gs-4426	157	184	central	central	ADJ
gs-4426	157	185	drugs	drug	NOUN
gs-4426	157	186	standard	standard	PROPN
gs-4426	157	187	control	control	PROPN
gs-4426	157	188	organisation	organisation	NOUN
gs-4426	157	189	(	(	PUNCT
gs-4426	157	190	cdsco	cdsco	PROPN
gs-4426	157	191	,	,	PUNCT
gs-4426	157	192	india	india	PROPN
gs-4426	157	193	):	):	PUNCT
gs-4426	157	194	marketing	marketing	NOUN
gs-4426	157	195	authorization	authorization	NOUN
gs-4426	157	196	approvals	approval	NOUN
gs-4426	157	197	professional	professional	ADJ
gs-4426	157	198	society	society	NOUN
gs-4426	157	199	resources	resource	VERB
gs-4426	157	200	information	information	NOUN
gs-4426	157	201	from	from	ADP
gs-4426	157	202	major	major	ADJ
gs-4426	157	203	professional	professional	ADJ
gs-4426	157	204	organizations	organization	NOUN
gs-4426	157	205	was	be	AUX
gs-4426	157	206	incorporated	incorporate	VERB
gs-4426	157	207	:	:	PUNCT
gs-4426	157	208	american	american	ADJ
gs-4426	157	209	society	society	NOUN
gs-4426	157	210	of	of	ADP
gs-4426	157	211	gene	gene	NOUN
gs-4426	157	212	and	and	CCONJ
gs-4426	157	213	cell	cell	NOUN
gs-4426	157	214	therapy	therapy	NOUN
gs-4426	157	215	(	(	PUNCT
gs-4426	157	216	asgct	asgct	PROPN
gs-4426	157	217	):	):	PUNCT
gs-4426	157	218	quarterly	quarterly	ADJ
gs-4426	157	219	industry	industry	NOUN
gs-4426	157	220	landscape	landscape	NOUN
gs-4426	157	221	reports	report	VERB
gs-4426	157	222	,	,	PUNCT
gs-4426	157	223	annual	annual	ADJ
gs-4426	157	224	meeting	meeting	NOUN
gs-4426	157	225	abstracts	abstract	VERB
gs-4426	157	226	international	international	ADJ
gs-4426	157	227	society	society	NOUN
gs-4426	157	228	for	for	ADP
gs-4426	157	229	cell	cell	NOUN
gs-4426	157	230	and	and	CCONJ
gs-4426	157	231	gene	gene	NOUN
gs-4426	157	232	therapy	therapy	NOUN
gs-4426	157	233	(	(	PUNCT
gs-4426	157	234	isct	isct	NOUN
gs-4426	157	235	):	):	PUNCT
gs-4426	157	236	position	position	NOUN
gs-4426	157	237	statements	statement	NOUN
gs-4426	157	238	,	,	PUNCT
gs-4426	157	239	approval	approval	NOUN
gs-4426	157	240	tracking	track	VERB
gs-4426	157	241	innovative	innovative	ADJ
gs-4426	157	242	genomics	genomic	NOUN
gs-4426	157	243	institute	institute	NOUN
gs-4426	157	244	(	(	PUNCT
gs-4426	157	245	igi	igi	PROPN
gs-4426	157	246	):	):	PUNCT
gs-4426	157	247	crispr	crispr	ADJ
gs-4426	157	248	clinical	clinical	ADJ
gs-4426	157	249	trial	trial	NOUN
gs-4426	157	250	tracking	tracking	NOUN
gs-4426	157	251	and	and	CCONJ
gs-4426	157	252	updates	update	VERB
gs-4426	157	253	alliance	alliance	NOUN
gs-4426	157	254	for	for	ADP
gs-4426	157	255	regenerative	regenerative	ADJ
gs-4426	157	256	medicine	medicine	NOUN
gs-4426	157	257	(	(	PUNCT
gs-4426	157	258	arm	arm	NOUN
gs-4426	157	259	):	):	PUNCT
gs-4426	157	260	industry	industry	NOUN
gs-4426	157	261	reports	report	NOUN
gs-4426	157	262	and	and	CCONJ
gs-4426	157	263	market	market	NOUN
gs-4426	157	264	analyses	analyse	VERB
gs-4426	157	265	industry	industry	NOUN
gs-4426	157	266	and	and	CCONJ
gs-4426	157	267	commercial	commercial	ADJ
gs-4426	157	268	sources	source	NOUN
gs-4426	157	269	supplementary	supplementary	ADJ
gs-4426	157	270	information	information	NOUN
gs-4426	157	271	was	be	AUX
gs-4426	157	272	obtained	obtain	VERB
gs-4426	157	273	from	from	ADP
gs-4426	157	274	:	:	PUNCT
gs-4426	157	275	company	company	NOUN
gs-4426	157	276	press	press	NOUN
gs-4426	157	277	releases	release	NOUN
gs-4426	157	278	and	and	CCONJ
gs-4426	157	279	investor	investor	NOUN
gs-4426	157	280	presentations	presentation	NOUN
gs-4426	157	281	georgian	georgian	NOUN
gs-4426	157	282	scientists/	scientists/	NUM
gs-4426	157	283	.	.	PUNCT
gs-4426	158	1	7	7	NUM
gs-4426	158	2	n	n	DET
gs-4426	158	3	4	4	NUM
gs-4426	158	4	,	,	PUNCT
gs-4426	158	5	2025	2025	NUM
gs-4426	158	6	605	605	NUM
gs-4426	158	7	industry	industry	NOUN
gs-4426	158	8	analyst	analyst	NOUN
gs-4426	158	9	reports	report	VERB
gs-4426	158	10	clinical	clinical	ADJ
gs-4426	158	11	trial	trial	NOUN
gs-4426	158	12	sponsor	sponsor	NOUN
gs-4426	158	13	websites	website	VERB
gs-4426	158	14	biotechnology	biotechnology	NOUN
gs-4426	158	15	industry	industry	NOUN
gs-4426	158	16	news	news	NOUN
gs-4426	158	17	sources	source	NOUN
gs-4426	158	18	(	(	PUNCT
gs-4426	158	19	with	with	ADP
gs-4426	158	20	verification	verification	NOUN
gs-4426	158	21	against	against	ADP
gs-4426	158	22	primary	primary	ADJ
gs-4426	158	23	sources	source	NOUN
gs-4426	158	24	)	)	PUNCT
gs-4426	158	25	limitations	limitation	VERB
gs-4426	158	26	several	several	ADJ
gs-4426	158	27	limitations	limitation	NOUN
gs-4426	158	28	of	of	ADP
gs-4426	158	29	this	this	DET
gs-4426	158	30	article	article	NOUN
gs-4426	158	31	methodology	methodology	NOUN
gs-4426	158	32	should	should	AUX
gs-4426	158	33	be	be	AUX
gs-4426	158	34	acknowledged	acknowledge	VERB
gs-4426	158	35	:	:	PUNCT
gs-4426	158	36	1	1	X
gs-4426	158	37	.	.	X
gs-4426	158	38	publication	publication	NOUN
gs-4426	158	39	bias	bias	NOUN
gs-4426	158	40	:	:	PUNCT
gs-4426	158	41	published	publish	VERB
gs-4426	158	42	positive	positive	ADJ
gs-4426	158	43	results	result	NOUN
gs-4426	158	44	may	may	AUX
gs-4426	158	45	be	be	AUX
gs-4426	158	46	overrepresented	overrepresente	VERB
gs-4426	158	47	compared	compare	VERB
gs-4426	158	48	to	to	ADP
gs-4426	158	49	negative	negative	ADJ
gs-4426	158	50	or	or	CCONJ
gs-4426	158	51	inconclusive	inconclusive	ADJ
gs-4426	158	52	findings	finding	NOUN
gs-4426	158	53	2	2	NUM
gs-4426	158	54	.	.	PUNCT
gs-4426	158	55	language	language	NOUN
gs-4426	158	56	restriction	restriction	NOUN
gs-4426	158	57	:	:	PUNCT
gs-4426	158	58	english	english	PROPN
gs-4426	158	59	-	-	PUNCT
gs-4426	158	60	only	only	ADV
gs-4426	158	61	publications	publication	NOUN
gs-4426	158	62	may	may	AUX
gs-4426	158	63	have	have	AUX
gs-4426	158	64	excluded	exclude	VERB
gs-4426	158	65	relevant	relevant	ADJ
gs-4426	158	66	non	non	ADJ
gs-4426	158	67	-	-	ADJ
gs-4426	158	68	english	english	ADJ
gs-4426	158	69	literature	literature	NOUN
gs-4426	158	70	3	3	X
gs-4426	158	71	.	.	PUNCT
gs-4426	158	72	grey	grey	PROPN
gs-4426	158	73	literature	literature	PROPN
gs-4426	158	74	:	:	PUNCT
gs-4426	158	75	limited	limited	ADJ
gs-4426	158	76	access	access	NOUN
gs-4426	158	77	to	to	ADP
gs-4426	158	78	unpublished	unpublished	ADJ
gs-4426	158	79	data	datum	NOUN
gs-4426	158	80	,	,	PUNCT
gs-4426	158	81	internal	internal	ADJ
gs-4426	158	82	company	company	NOUN
gs-4426	158	83	reports	report	VERB
gs-4426	158	84	,	,	PUNCT
gs-4426	158	85	or	or	CCONJ
gs-4426	158	86	failed	fail	VERB
gs-4426	158	87	trials	trial	NOUN
gs-4426	158	88	not	not	PART
gs-4426	158	89	publicly	publicly	ADV
gs-4426	158	90	disclosed	disclose	VERB
gs-4426	158	91	4	4	NUM
gs-4426	158	92	.	.	PUNCT
gs-4426	158	93	data	datum	NOUN
gs-4426	158	94	completeness	completeness	NOUN
gs-4426	158	95	:	:	PUNCT
gs-4426	158	96	clinical	clinical	ADJ
gs-4426	158	97	trial	trial	NOUN
gs-4426	158	98	registries	registry	NOUN
gs-4426	158	99	may	may	AUX
gs-4426	158	100	contain	contain	VERB
gs-4426	158	101	incomplete	incomplete	ADJ
gs-4426	158	102	or	or	CCONJ
gs-4426	158	103	outdated	outdated	ADJ
gs-4426	158	104	information	information	NOUN
gs-4426	158	105	5	5	NUM
gs-4426	158	106	.	.	PUNCT
gs-4426	158	107	temporal	temporal	ADJ
gs-4426	158	108	lag	lag	NOUN
gs-4426	158	109	:	:	PUNCT
gs-4426	158	110	recent	recent	ADJ
gs-4426	158	111	developments	development	NOUN
gs-4426	158	112	may	may	AUX
gs-4426	158	113	not	not	PART
gs-4426	158	114	yet	yet	ADV
gs-4426	158	115	be	be	AUX
gs-4426	158	116	reflected	reflect	VERB
gs-4426	158	117	in	in	ADP
gs-4426	158	118	peer	peer	NOUN
gs-4426	158	119	-	-	PUNCT
gs-4426	158	120	articleed	articleed	NOUN
gs-4426	158	121	literature	literature	NOUN
gs-4426	158	122	6	6	NUM
gs-4426	158	123	.	.	PUNCT
gs-4426	159	1	proprietary	proprietary	ADJ
gs-4426	159	2	information	information	NOUN
gs-4426	159	3	:	:	PUNCT
gs-4426	159	4	detailed	detailed	ADJ
gs-4426	159	5	technical	technical	ADJ
gs-4426	159	6	or	or	CCONJ
gs-4426	159	7	commercial	commercial	ADJ
gs-4426	159	8	information	information	NOUN
gs-4426	159	9	may	may	AUX
gs-4426	159	10	be	be	AUX
gs-4426	159	11	unavailable	unavailable	ADJ
gs-4426	159	12	due	due	ADJ
gs-4426	159	13	to	to	ADP
gs-4426	159	14	competitive	competitive	ADJ
gs-4426	159	15	considerations	consideration	NOUN
gs-4426	159	16	7	7	NUM
gs-4426	159	17	.	.	X
gs-4426	159	18	rapid	rapid	ADJ
gs-4426	159	19	field	field	NOUN
gs-4426	159	20	evolution	evolution	NOUN
gs-4426	159	21	:	:	PUNCT
gs-4426	159	22	the	the	DET
gs-4426	159	23	fast	fast	ADJ
gs-4426	159	24	pace	pace	NOUN
gs-4426	159	25	of	of	ADP
gs-4426	159	26	gene	gene	NOUN
gs-4426	159	27	therapy	therapy	NOUN
gs-4426	159	28	development	development	NOUN
gs-4426	159	29	means	mean	VERB
gs-4426	159	30	some	some	DET
gs-4426	159	31	information	information	NOUN
gs-4426	159	32	may	may	AUX
gs-4426	159	33	become	become	VERB
gs-4426	159	34	outdated	outdated	ADJ
gs-4426	159	35	quickly	quickly	ADV
gs-4426	159	36	ethical	ethical	ADJ
gs-4426	159	37	considerations	consideration	NOUN
gs-4426	159	38	this	this	DET
gs-4426	159	39	article	article	NOUN
gs-4426	159	40	synthesizes	synthesize	VERB
gs-4426	159	41	publicly	publicly	ADV
gs-4426	159	42	available	available	ADJ
gs-4426	159	43	information	information	NOUN
gs-4426	159	44	and	and	CCONJ
gs-4426	159	45	does	do	AUX
gs-4426	159	46	not	not	PART
gs-4426	159	47	involve	involve	VERB
gs-4426	159	48	human	human	ADJ
gs-4426	159	49	subjects	subject	NOUN
gs-4426	159	50	’	'	PUNCT
gs-4426	159	51	research	research	NOUN
gs-4426	159	52	,	,	PUNCT
gs-4426	159	53	animal	animal	NOUN
gs-4426	159	54	experimentation	experimentation	NOUN
gs-4426	159	55	,	,	PUNCT
gs-4426	159	56	or	or	CCONJ
gs-4426	159	57	collection	collection	NOUN
gs-4426	159	58	of	of	ADP
gs-4426	159	59	primary	primary	ADJ
gs-4426	159	60	data	datum	NOUN
gs-4426	159	61	.	.	PUNCT
gs-4426	160	1	all	all	DET
gs-4426	160	2	information	information	NOUN
gs-4426	160	3	sources	source	NOUN
gs-4426	160	4	are	be	AUX
gs-4426	160	5	appropriately	appropriately	ADV
gs-4426	160	6	cited	cite	VERB
gs-4426	160	7	.	.	PUNCT
gs-4426	161	1	potential	potential	ADJ
gs-4426	161	2	conflicts	conflict	NOUN
gs-4426	161	3	of	of	ADP
gs-4426	161	4	interest	interest	NOUN
gs-4426	161	5	in	in	ADP
gs-4426	161	6	source	source	NOUN
gs-4426	161	7	materials	material	NOUN
gs-4426	161	8	were	be	AUX
gs-4426	161	9	considered	consider	VERB
gs-4426	161	10	during	during	ADP
gs-4426	161	11	synthesis	synthesis	NOUN
gs-4426	161	12	and	and	CCONJ
gs-4426	161	13	interpretation	interpretation	NOUN
gs-4426	161	14	.	.	PUNCT
gs-4426	162	1	data	datum	NOUN
gs-4426	162	2	availability	availability	NOUN
gs-4426	162	3	statement	statement	NOUN
gs-4426	162	4	all	all	DET
gs-4426	162	5	data	datum	NOUN
gs-4426	162	6	supporting	support	VERB
gs-4426	162	7	the	the	DET
gs-4426	162	8	conclusions	conclusion	NOUN
gs-4426	162	9	of	of	ADP
gs-4426	162	10	this	this	DET
gs-4426	162	11	article	article	NOUN
gs-4426	162	12	are	be	AUX
gs-4426	162	13	available	available	ADJ
gs-4426	162	14	in	in	ADP
gs-4426	162	15	the	the	DET
gs-4426	162	16	cited	cite	VERB
gs-4426	162	17	references	reference	NOUN
gs-4426	162	18	.	.	PUNCT
gs-4426	163	1	clinical	clinical	ADJ
gs-4426	163	2	trial	trial	NOUN
gs-4426	163	3	data	datum	NOUN
gs-4426	163	4	are	be	AUX
gs-4426	163	5	publicly	publicly	ADV
gs-4426	163	6	accessible	accessible	ADJ
gs-4426	163	7	through	through	ADP
gs-4426	163	8	clinicaltrials.gov	clinicaltrials.gov	PROPN
gs-4426	163	9	and	and	CCONJ
gs-4426	163	10	equivalent	equivalent	ADJ
gs-4426	163	11	registries	registry	NOUN
gs-4426	163	12	.	.	PUNCT
gs-4426	164	1	regulatory	regulatory	ADJ
gs-4426	164	2	approval	approval	NOUN
gs-4426	164	3	information	information	NOUN
gs-4426	164	4	is	be	AUX
gs-4426	164	5	available	available	ADJ
gs-4426	164	6	through	through	ADP
gs-4426	164	7	fda	fda	PROPN
gs-4426	164	8	,	,	PUNCT
gs-4426	164	9	ema	ema	PROPN
gs-4426	164	10	,	,	PUNCT
gs-4426	164	11	and	and	CCONJ
gs-4426	164	12	other	other	ADJ
gs-4426	164	13	regulatory	regulatory	ADJ
gs-4426	164	14	agency	agency	NOUN
gs-4426	164	15	websites	website	NOUN
gs-4426	164	16	.	.	PUNCT
gs-4426	165	1	supplementary	supplementary	ADJ
gs-4426	165	2	data	datum	NOUN
gs-4426	165	3	tables	table	NOUN
gs-4426	165	4	summarizing	summarize	VERB
gs-4426	165	5	clinical	clinical	ADJ
gs-4426	165	6	trials	trial	NOUN
gs-4426	165	7	and	and	CCONJ
gs-4426	165	8	approvals	approval	NOUN
gs-4426	165	9	are	be	AUX
gs-4426	165	10	available	available	ADJ
gs-4426	165	11	upon	upon	SCONJ
gs-4426	165	12	request	request	NOUN
gs-4426	165	13	.	.	PUNCT
gs-4426	166	1	results	result	VERB
gs-4426	166	2	georgian	georgian	NOUN
gs-4426	166	3	scientists/	scientists/	NUM
gs-4426	166	4	.	.	PUNCT
gs-4426	167	1	7	7	NUM
gs-4426	167	2	n	n	DET
gs-4426	167	3	4	4	NUM
gs-4426	167	4	,	,	PUNCT
gs-4426	167	5	2025	2025	NUM
gs-4426	167	6	606	606	NUM
gs-4426	167	7	figure	figure	NOUN
gs-4426	167	8	1	1	NUM
gs-4426	167	9	.	.	PUNCT
gs-4426	168	1	overview	overview	NOUN
gs-4426	168	2	of	of	ADP
gs-4426	168	3	gene	gene	NOUN
gs-4426	168	4	therapy	therapy	NOUN
gs-4426	168	5	advances	advance	VERB
gs-4426	168	6	in	in	ADP
gs-4426	168	7	2024	2024	NUM
gs-4426	168	8	-	-	SYM
gs-4426	168	9	2025	2025	NUM
gs-4426	168	10	.	.	PUNCT
gs-4426	169	1	comprehensive	comprehensive	ADJ
gs-4426	169	2	landscape	landscape	NOUN
gs-4426	169	3	of	of	ADP
gs-4426	169	4	gene	gene	NOUN
gs-4426	169	5	therapy	therapy	NOUN
gs-4426	169	6	showing	show	VERB
gs-4426	169	7	:	:	PUNCT
gs-4426	169	8	(	(	PUNCT
gs-4426	169	9	top	top	ADJ
gs-4426	169	10	)	)	PUNCT
gs-4426	169	11	four	four	NUM
gs-4426	169	12	principal	principal	ADJ
gs-4426	169	13	therapeutic	therapeutic	ADJ
gs-4426	169	14	modalities	modality	NOUN
gs-4426	169	15	—	—	PUNCT
gs-4426	169	16	viral	viral	ADJ
gs-4426	169	17	vectors	vector	NOUN
gs-4426	169	18	(	(	PUNCT
gs-4426	169	19	aav	aav	NOUN
gs-4426	169	20	,	,	PUNCT
gs-4426	169	21	lentivirus	lentivirus	NOUN
gs-4426	169	22	)	)	PUNCT
gs-4426	169	23	,	,	PUNCT
gs-4426	169	24	crispr	crispr	ADJ
gs-4426	169	25	/	/	SYM
gs-4426	169	26	gene	gene	NOUN
gs-4426	169	27	editing	editing	NOUN
gs-4426	169	28	,	,	PUNCT
gs-4426	169	29	car	car	NOUN
gs-4426	169	30	-	-	PUNCT
gs-4426	169	31	t	t	NOUN
gs-4426	169	32	cell	cell	NOUN
gs-4426	169	33	therapy	therapy	NOUN
gs-4426	169	34	,	,	PUNCT
gs-4426	169	35	and	and	CCONJ
gs-4426	169	36	rna	rna	NOUN
gs-4426	169	37	therapeutics	therapeutic	NOUN
gs-4426	169	38	—	—	PUNCT
gs-4426	169	39	each	each	PRON
gs-4426	169	40	with	with	ADP
gs-4426	169	41	distinct	distinct	ADJ
gs-4426	169	42	mechanisms	mechanism	NOUN
gs-4426	169	43	and	and	CCONJ
gs-4426	169	44	applications	application	NOUN
gs-4426	169	45	.	.	PUNCT
gs-4426	170	1	(	(	PUNCT
gs-4426	170	2	middle	middle	ADJ
gs-4426	170	3	)	)	PUNCT
gs-4426	170	4	timeline	timeline	NOUN
gs-4426	170	5	of	of	ADP
gs-4426	170	6	major	major	ADJ
gs-4426	170	7	milestones	milestone	NOUN
gs-4426	170	8	from	from	ADP
gs-4426	170	9	2017	2017	NUM
gs-4426	170	10	(	(	PUNCT
gs-4426	170	11	first	first	ADJ
gs-4426	170	12	fda	fda	PROPN
gs-4426	170	13	approvals	approval	NOUN
gs-4426	170	14	)	)	PUNCT
gs-4426	170	15	through	through	ADP
gs-4426	170	16	2025	2025	NUM
gs-4426	170	17	(	(	PUNCT
gs-4426	170	18	personalized	personalize	VERB
gs-4426	170	19	crispr	crispr	ADJ
gs-4426	170	20	therapy	therapy	NOUN
gs-4426	170	21	)	)	PUNCT
gs-4426	170	22	,	,	PUNCT
gs-4426	170	23	highlighting	highlight	VERB
gs-4426	170	24	2023	2023	NUM
gs-4426	170	25	as	as	ADP
gs-4426	170	26	marking	mark	VERB
gs-4426	170	27	first	first	ADJ
gs-4426	170	28	crispr	crispr	NOUN
gs-4426	170	29	-	-	PUNCT
gs-4426	170	30	based	base	VERB
gs-4426	170	31	medicine	medicine	NOUN
gs-4426	170	32	approval	approval	NOUN
gs-4426	170	33	(	(	PUNCT
gs-4426	170	34	casgevy	casgevy	NOUN
gs-4426	170	35	)	)	PUNCT
gs-4426	170	36	and	and	CCONJ
gs-4426	170	37	2024	2024	NUM
gs-4426	170	38	achieving	achieving	NOUN
gs-4426	170	39	record	record	NOUN
gs-4426	170	40	seven	seven	NUM
gs-4426	170	41	fda	fda	PROPN
gs-4426	170	42	approvals	approval	NOUN
gs-4426	170	43	.	.	PUNCT
gs-4426	171	1	(	(	PUNCT
gs-4426	171	2	bottom	bottom	ADJ
gs-4426	171	3	)	)	PUNCT
gs-4426	171	4	clinical	clinical	ADJ
gs-4426	171	5	applications	application	NOUN
gs-4426	171	6	distributed	distribute	VERB
gs-4426	171	7	across	across	ADP
gs-4426	171	8	disease	disease	NOUN
gs-4426	171	9	areas	area	NOUN
gs-4426	171	10	:	:	PUNCT
gs-4426	171	11	blood	blood	NOUN
gs-4426	171	12	disorders	disorder	NOUN
gs-4426	171	13	(	(	PUNCT
gs-4426	171	14	red	red	ADJ
gs-4426	171	15	)	)	PUNCT
gs-4426	171	16	,	,	PUNCT
gs-4426	171	17	cancer	cancer	NOUN
gs-4426	171	18	(	(	PUNCT
gs-4426	171	19	purple	purple	ADJ
gs-4426	171	20	)	)	PUNCT
gs-4426	171	21	,	,	PUNCT
gs-4426	171	22	cardiovascular	cardiovascular	ADJ
gs-4426	171	23	disease	disease	NOUN
gs-4426	171	24	(	(	PUNCT
gs-4426	171	25	blue	blue	NOUN
gs-4426	171	26	)	)	PUNCT
gs-4426	171	27	,	,	PUNCT
gs-4426	171	28	rare	rare	ADJ
gs-4426	171	29	genetic	genetic	ADJ
gs-4426	171	30	diseases	disease	NOUN
gs-4426	171	31	(	(	PUNCT
gs-4426	171	32	green	green	ADJ
gs-4426	171	33	)	)	PUNCT
gs-4426	171	34	,	,	PUNCT
gs-4426	171	35	diabetes	diabetes	NOUN
gs-4426	171	36	(	(	PUNCT
gs-4426	171	37	orange	orange	ADJ
gs-4426	171	38	)	)	PUNCT
gs-4426	171	39	,	,	PUNCT
gs-4426	171	40	and	and	CCONJ
gs-4426	171	41	autoimmune	autoimmune	ADJ
gs-4426	171	42	disorders	disorder	NOUN
gs-4426	171	43	(	(	PUNCT
gs-4426	171	44	yellow	yellow	ADJ
gs-4426	171	45	)	)	PUNCT
gs-4426	171	46	.	.	PUNCT
gs-4426	172	1	(	(	PUNCT
gs-4426	172	2	right	right	ADJ
gs-4426	172	3	)	)	PUNCT
gs-4426	172	4	current	current	ADJ
gs-4426	172	5	statistics	statistic	NOUN
gs-4426	172	6	showing	show	VERB
gs-4426	172	7	250	250	NUM
gs-4426	172	8	+	+	CCONJ
gs-4426	172	9	active	active	ADJ
gs-4426	172	10	crispr	crispr	ADJ
gs-4426	172	11	clinical	clinical	ADJ
gs-4426	172	12	trials	trial	NOUN
gs-4426	172	13	globally	globally	ADV
gs-4426	172	14	,	,	PUNCT
gs-4426	172	15	3,500	3,500	NUM
gs-4426	172	16	+	+	NUM
gs-4426	172	17	therapies	therapy	NOUN
gs-4426	172	18	in	in	ADP
gs-4426	172	19	development	development	NOUN
gs-4426	172	20	across	across	ADP
gs-4426	172	21	all	all	DET
gs-4426	172	22	stages	stage	NOUN
gs-4426	172	23	,	,	PUNCT
gs-4426	172	24	and	and	CCONJ
gs-4426	172	25	projections	projection	NOUN
gs-4426	172	26	of	of	ADP
gs-4426	172	27	10	10	NUM
gs-4426	172	28	-	-	SYM
gs-4426	172	29	20	20	NUM
gs-4426	172	30	annual	annual	ADJ
gs-4426	172	31	fda	fda	PROPN
gs-4426	172	32	approvals	approval	NOUN
gs-4426	172	33	through	through	ADP
gs-4426	172	34	2025	2025	NUM
gs-4426	172	35	.	.	PUNCT
gs-4426	173	1	the	the	DET
gs-4426	173	2	figure	figure	NOUN
gs-4426	173	3	illustrates	illustrate	VERB
gs-4426	173	4	gene	gene	NOUN
gs-4426	173	5	therapy	therapy	NOUN
gs-4426	173	6	's	's	PART
gs-4426	173	7	evolution	evolution	NOUN
gs-4426	173	8	from	from	ADP
gs-4426	173	9	experimental	experimental	ADJ
gs-4426	173	10	technology	technology	NOUN
gs-4426	173	11	to	to	ADP
gs-4426	173	12	established	establish	VERB
gs-4426	173	13	medical	medical	ADJ
gs-4426	173	14	modality	modality	NOUN
gs-4426	173	15	with	with	ADP
gs-4426	173	16	diverse	diverse	ADJ
gs-4426	173	17	platforms	platform	NOUN
gs-4426	173	18	addressing	address	VERB
gs-4426	173	19	expanding	expand	VERB
gs-4426	173	20	disease	disease	NOUN
gs-4426	173	21	areas	area	NOUN
gs-4426	173	22	.	.	PUNCT
gs-4426	174	1	georgian	georgian	NOUN
gs-4426	174	2	scientists/	scientists/	NUM
gs-4426	174	3	.	.	PUNCT
gs-4426	175	1	7	7	NUM
gs-4426	175	2	n	n	DET
gs-4426	175	3	4	4	NUM
gs-4426	175	4	,	,	PUNCT
gs-4426	175	5	2025	2025	NUM
gs-4426	175	6	607	607	NUM
gs-4426	175	7	figure	figure	NOUN
gs-4426	175	8	2	2	NUM
gs-4426	175	9	:	:	PUNCT
gs-4426	175	10	gene	gene	NOUN
gs-4426	175	11	therapy	therapy	NOUN
gs-4426	175	12	clinical	clinical	ADJ
gs-4426	175	13	development	development	NOUN
gs-4426	175	14	pipeline	pipeline	NOUN
gs-4426	175	15	and	and	CCONJ
gs-4426	175	16	regulatory	regulatory	ADJ
gs-4426	175	17	approvals	approval	NOUN
gs-4426	175	18	(	(	PUNCT
gs-4426	175	19	2017	2017	NUM
gs-4426	175	20	-	-	SYM
gs-4426	175	21	2025	2025	NUM
gs-4426	175	22	)	)	PUNCT
gs-4426	175	23	figure	figure	NOUN
gs-4426	175	24	description	description	NOUN
gs-4426	175	25	for	for	ADP
gs-4426	175	26	article	article	NOUN
gs-4426	175	27	text	text	NOUN
gs-4426	175	28	:	:	PUNCT
gs-4426	175	29	figure	figure	NOUN
gs-4426	175	30	2	2	NUM
gs-4426	175	31	illustrates	illustrate	VERB
gs-4426	175	32	the	the	DET
gs-4426	175	33	exponential	exponential	ADJ
gs-4426	175	34	growth	growth	NOUN
gs-4426	175	35	and	and	CCONJ
gs-4426	175	36	diversification	diversification	NOUN
gs-4426	175	37	of	of	ADP
gs-4426	175	38	the	the	DET
gs-4426	175	39	gene	gene	NOUN
gs-4426	175	40	therapy	therapy	NOUN
gs-4426	175	41	field	field	NOUN
gs-4426	175	42	over	over	ADP
gs-4426	175	43	the	the	DET
gs-4426	175	44	past	past	ADJ
gs-4426	175	45	eight	eight	NUM
gs-4426	175	46	years	year	NOUN
gs-4426	175	47	.	.	PUNCT
gs-4426	176	1	the	the	DET
gs-4426	176	2	left	left	ADJ
gs-4426	176	3	panel	panel	NOUN
gs-4426	176	4	demonstrates	demonstrate	VERB
gs-4426	176	5	the	the	DET
gs-4426	176	6	accelerating	accelerate	VERB
gs-4426	176	7	pace	pace	NOUN
gs-4426	176	8	of	of	ADP
gs-4426	176	9	fda	fda	PROPN
gs-4426	176	10	gene	gene	NOUN
gs-4426	176	11	therapy	therapy	NOUN
gs-4426	176	12	approvals	approval	NOUN
gs-4426	176	13	,	,	PUNCT
gs-4426	176	14	increasing	increase	VERB
gs-4426	176	15	from	from	ADP
gs-4426	176	16	a	a	DET
gs-4426	176	17	single	single	ADJ
gs-4426	176	18	approval	approval	NOUN
gs-4426	176	19	in	in	ADP
gs-4426	176	20	2017	2017	NUM
gs-4426	176	21	to	to	PART
gs-4426	176	22	seven	seven	NUM
gs-4426	176	23	approvals	approval	NOUN
gs-4426	176	24	in	in	ADP
gs-4426	176	25	2024	2024	NUM
gs-4426	176	26	,	,	PUNCT
gs-4426	176	27	representing	represent	VERB
gs-4426	176	28	a	a	DET
gs-4426	176	29	seven	seven	NUM
gs-4426	176	30	-	-	ADJ
gs-4426	176	31	fold	fold	ADJ
gs-4426	176	32	increase	increase	NOUN
gs-4426	176	33	.	.	PUNCT
gs-4426	177	1	this	this	DET
gs-4426	177	2	upward	upward	ADJ
gs-4426	177	3	trajectory	trajectory	NOUN
gs-4426	177	4	reflects	reflect	VERB
gs-4426	177	5	both	both	CCONJ
gs-4426	177	6	the	the	DET
gs-4426	177	7	maturation	maturation	NOUN
gs-4426	177	8	of	of	ADP
gs-4426	177	9	gene	gene	NOUN
gs-4426	177	10	therapy	therapy	NOUN
gs-4426	177	11	technologies	technology	NOUN
gs-4426	177	12	and	and	CCONJ
gs-4426	177	13	increasing	increase	VERB
gs-4426	177	14	regulatory	regulatory	ADJ
gs-4426	177	15	confidence	confidence	NOUN
gs-4426	177	16	in	in	ADP
gs-4426	177	17	these	these	DET
gs-4426	177	18	therapeutic	therapeutic	ADJ
gs-4426	177	19	modalities	modality	NOUN
gs-4426	177	20	.	.	PUNCT
gs-4426	178	1	the	the	DET
gs-4426	178	2	landmark	landmark	PROPN
gs-4426	178	3	year	year	NOUN
gs-4426	178	4	of	of	ADP
gs-4426	178	5	2023	2023	NUM
gs-4426	178	6	is	be	AUX
gs-4426	178	7	notably	notably	ADV
gs-4426	178	8	highlighted	highlight	VERB
gs-4426	178	9	as	as	ADP
gs-4426	178	10	marking	mark	VERB
gs-4426	178	11	the	the	DET
gs-4426	178	12	approval	approval	NOUN
gs-4426	178	13	of	of	ADP
gs-4426	178	14	casgevy	casgevy	NOUN
gs-4426	178	15	,	,	PUNCT
gs-4426	178	16	the	the	DET
gs-4426	178	17	first	first	ADJ
gs-4426	178	18	crispr	crispr	NOUN
gs-4426	178	19	-	-	PUNCT
gs-4426	178	20	based	base	VERB
gs-4426	178	21	therapy	therapy	NOUN
gs-4426	178	22	,	,	PUNCT
gs-4426	178	23	which	which	PRON
gs-4426	178	24	represents	represent	VERB
gs-4426	178	25	a	a	DET
gs-4426	178	26	watershed	watershed	ADJ
gs-4426	178	27	moment	moment	NOUN
gs-4426	178	28	in	in	ADP
gs-4426	178	29	the	the	DET
gs-4426	178	30	clinical	clinical	ADJ
gs-4426	178	31	translation	translation	NOUN
gs-4426	178	32	of	of	ADP
gs-4426	178	33	gene	gene	NOUN
gs-4426	178	34	editing	edit	VERB
gs-4426	178	35	technology	technology	NOUN
gs-4426	178	36	.	.	PUNCT
gs-4426	179	1	the	the	DET
gs-4426	179	2	center	center	NOUN
gs-4426	179	3	panel	panel	NOUN
gs-4426	179	4	provides	provide	VERB
gs-4426	179	5	a	a	DET
gs-4426	179	6	snapshot	snapshot	NOUN
gs-4426	179	7	of	of	ADP
gs-4426	179	8	the	the	DET
gs-4426	179	9	current	current	ADJ
gs-4426	179	10	clinical	clinical	ADJ
gs-4426	179	11	development	development	NOUN
gs-4426	179	12	pipeline	pipeline	NOUN
gs-4426	179	13	as	as	ADP
gs-4426	179	14	of	of	ADP
gs-4426	179	15	2025	2025	NUM
gs-4426	179	16	,	,	PUNCT
gs-4426	179	17	categorized	categorize	VERB
gs-4426	179	18	by	by	ADP
gs-4426	179	19	trial	trial	NOUN
gs-4426	179	20	phase	phase	NOUN
gs-4426	179	21	.	.	PUNCT
gs-4426	180	1	the	the	DET
gs-4426	180	2	distribution	distribution	NOUN
gs-4426	180	3	reveals	reveal	VERB
gs-4426	180	4	a	a	DET
gs-4426	180	5	robust	robust	ADJ
gs-4426	180	6	early	early	ADJ
gs-4426	180	7	-	-	PUNCT
gs-4426	180	8	stage	stage	NOUN
gs-4426	180	9	pipeline	pipeline	NOUN
gs-4426	180	10	with	with	ADP
gs-4426	180	11	120	120	NUM
gs-4426	180	12	trials	trial	NOUN
gs-4426	180	13	in	in	ADP
gs-4426	180	14	phase	phase	NOUN
gs-4426	180	15	i	i	PROPN
gs-4426	180	16	,	,	PUNCT
gs-4426	180	17	indicating	indicate	VERB
gs-4426	180	18	sustained	sustained	ADJ
gs-4426	180	19	investment	investment	NOUN
gs-4426	180	20	in	in	ADP
gs-4426	180	21	novel	novel	ADJ
gs-4426	180	22	gene	gene	NOUN
gs-4426	180	23	therapy	therapy	NOUN
gs-4426	180	24	approaches	approach	VERB
gs-4426	180	25	.	.	PUNCT
gs-4426	181	1	the	the	DET
gs-4426	181	2	presence	presence	NOUN
gs-4426	181	3	of	of	ADP
gs-4426	181	4	80	80	NUM
gs-4426	181	5	combined	combine	VERB
gs-4426	181	6	phase	phase	NOUN
gs-4426	181	7	i	i	PROPN
gs-4426	181	8	/	/	SYM
gs-4426	181	9	ii	ii	PROPN
gs-4426	181	10	trials	trial	NOUN
gs-4426	181	11	reflects	reflect	VERB
gs-4426	181	12	the	the	DET
gs-4426	181	13	adaptive	adaptive	ADJ
gs-4426	181	14	trial	trial	NOUN
gs-4426	181	15	designs	design	NOUN
gs-4426	181	16	increasingly	increasingly	ADV
gs-4426	181	17	employed	employ	VERB
gs-4426	181	18	in	in	ADP
gs-4426	181	19	rare	rare	ADJ
gs-4426	181	20	disease	disease	NOUN
gs-4426	181	21	settings	setting	NOUN
gs-4426	181	22	where	where	SCONJ
gs-4426	181	23	traditional	traditional	ADJ
gs-4426	181	24	phase	phase	NOUN
gs-4426	181	25	-	-	PUNCT
gs-4426	181	26	sequential	sequential	ADJ
gs-4426	181	27	development	development	NOUN
gs-4426	181	28	may	may	AUX
gs-4426	181	29	be	be	AUX
gs-4426	181	30	inefficient	inefficient	ADJ
gs-4426	181	31	.	.	PUNCT
gs-4426	182	1	phase	phase	NOUN
gs-4426	182	2	ii	ii	PROPN
gs-4426	182	3	trials	trial	NOUN
gs-4426	182	4	(	(	PUNCT
gs-4426	182	5	60	60	NUM
gs-4426	182	6	studies	study	NOUN
gs-4426	182	7	)	)	PUNCT
gs-4426	182	8	represent	represent	VERB
gs-4426	182	9	therapies	therapy	NOUN
gs-4426	182	10	undergoing	undergo	VERB
gs-4426	182	11	efficacy	efficacy	NOUN
gs-4426	182	12	evaluation	evaluation	NOUN
gs-4426	182	13	,	,	PUNCT
gs-4426	182	14	while	while	SCONJ
gs-4426	182	15	40	40	NUM
gs-4426	182	16	phase	phase	NOUN
gs-4426	182	17	iii	iii	NUM
gs-4426	182	18	trials	trial	NOUN
gs-4426	182	19	indicate	indicate	VERB
gs-4426	182	20	a	a	DET
gs-4426	182	21	substantial	substantial	ADJ
gs-4426	182	22	number	number	NOUN
gs-4426	182	23	of	of	ADP
gs-4426	182	24	gene	gene	NOUN
gs-4426	182	25	therapies	therapy	NOUN
gs-4426	182	26	approaching	approach	VERB
gs-4426	182	27	regulatory	regulatory	ADJ
gs-4426	182	28	decision	decision	NOUN
gs-4426	182	29	points	point	NOUN
gs-4426	182	30	.	.	PUNCT
gs-4426	183	1	this	this	DET
gs-4426	183	2	distribution	distribution	NOUN
gs-4426	183	3	suggests	suggest	VERB
gs-4426	183	4	a	a	DET
gs-4426	183	5	healthy	healthy	ADJ
gs-4426	183	6	pipeline	pipeline	NOUN
gs-4426	183	7	that	that	PRON
gs-4426	183	8	should	should	AUX
gs-4426	183	9	yield	yield	VERB
gs-4426	183	10	additional	additional	ADJ
gs-4426	183	11	approvals	approval	NOUN
gs-4426	183	12	in	in	ADP
gs-4426	183	13	the	the	DET
gs-4426	183	14	coming	come	VERB
gs-4426	183	15	years	year	NOUN
gs-4426	183	16	.	.	PUNCT
gs-4426	184	1	the	the	DET
gs-4426	184	2	right	right	ADJ
gs-4426	184	3	panel	panel	NOUN
gs-4426	184	4	depicts	depict	VERB
gs-4426	184	5	the	the	DET
gs-4426	184	6	therapeutic	therapeutic	ADJ
gs-4426	184	7	area	area	NOUN
gs-4426	184	8	distribution	distribution	NOUN
gs-4426	184	9	of	of	ADP
gs-4426	184	10	gene	gene	NOUN
gs-4426	184	11	therapy	therapy	NOUN
gs-4426	184	12	development	development	NOUN
gs-4426	184	13	efforts	effort	NOUN
gs-4426	184	14	in	in	ADP
gs-4426	184	15	2024	2024	NUM
gs-4426	184	16	-	-	SYM
gs-4426	184	17	2025	2025	NUM
gs-4426	184	18	.	.	PUNCT
gs-4426	185	1	cancer	cancer	NOUN
gs-4426	185	2	remains	remain	VERB
gs-4426	185	3	the	the	DET
gs-4426	185	4	dominant	dominant	ADJ
gs-4426	185	5	indication	indication	NOUN
gs-4426	185	6	,	,	PUNCT
gs-4426	185	7	accounting	account	VERB
gs-4426	185	8	for	for	ADP
gs-4426	185	9	49	49	NUM
gs-4426	185	10	%	%	NOUN
gs-4426	185	11	of	of	ADP
gs-4426	185	12	clinical	clinical	ADJ
gs-4426	185	13	development	development	NOUN
gs-4426	185	14	activities	activity	NOUN
gs-4426	185	15	,	,	PUNCT
gs-4426	185	16	reflecting	reflect	VERB
gs-4426	185	17	both	both	CCONJ
gs-4426	185	18	the	the	DET
gs-4426	185	19	large	large	ADJ
gs-4426	185	20	unmet	unmet	NOUN
gs-4426	185	21	medical	medical	ADJ
gs-4426	185	22	need	need	NOUN
gs-4426	185	23	and	and	CCONJ
gs-4426	185	24	the	the	DET
gs-4426	185	25	success	success	NOUN
gs-4426	185	26	of	of	ADP
gs-4426	185	27	car	car	NOUN
gs-4426	185	28	-	-	PUNCT
gs-4426	185	29	t	t	NOUN
gs-4426	185	30	cell	cell	NOUN
gs-4426	185	31	therapies	therapy	NOUN
gs-4426	185	32	in	in	ADP
gs-4426	185	33	hematological	hematological	ADJ
gs-4426	185	34	malignancies	malignancy	NOUN
gs-4426	185	35	.	.	PUNCT
gs-4426	186	1	blood	blood	NOUN
gs-4426	186	2	disorders	disorder	NOUN
gs-4426	186	3	represent	represent	VERB
gs-4426	186	4	18	18	NUM
gs-4426	186	5	%	%	NOUN
gs-4426	186	6	of	of	ADP
gs-4426	186	7	the	the	DET
gs-4426	186	8	pipeline	pipeline	NOUN
gs-4426	186	9	,	,	PUNCT
gs-4426	186	10	driven	drive	VERB
gs-4426	186	11	by	by	ADP
gs-4426	186	12	the	the	DET
gs-4426	186	13	clinical	clinical	ADJ
gs-4426	186	14	success	success	NOUN
gs-4426	186	15	in	in	ADP
gs-4426	186	16	sickle	sickle	NOUN
gs-4426	186	17	cell	cell	NOUN
gs-4426	186	18	disease	disease	NOUN
gs-4426	186	19	,	,	PUNCT
gs-4426	186	20	thalassemia	thalassemia	NOUN
gs-4426	186	21	,	,	PUNCT
gs-4426	186	22	and	and	CCONJ
gs-4426	186	23	hemophilia	hemophilia	PROPN
gs-4426	186	24	.	.	PUNCT
gs-4426	187	1	rare	rare	ADJ
gs-4426	187	2	genetic	genetic	ADJ
gs-4426	187	3	diseases	disease	NOUN
gs-4426	187	4	comprise	comprise	VERB
gs-4426	187	5	15	15	NUM
gs-4426	187	6	%	%	NOUN
gs-4426	187	7	of	of	ADP
gs-4426	187	8	development	development	NOUN
gs-4426	187	9	efforts	effort	NOUN
gs-4426	187	10	,	,	PUNCT
gs-4426	187	11	consistent	consistent	ADJ
gs-4426	187	12	with	with	ADP
gs-4426	187	13	gene	gene	NOUN
gs-4426	187	14	therapy	therapy	NOUN
gs-4426	187	15	's	's	PART
gs-4426	187	16	ability	ability	NOUN
gs-4426	187	17	to	to	PART
gs-4426	187	18	address	address	VERB
gs-4426	187	19	monogenic	monogenic	ADJ
gs-4426	187	20	disorders	disorder	NOUN
gs-4426	187	21	.	.	PUNCT
gs-4426	188	1	notably	notably	ADV
gs-4426	188	2	,	,	PUNCT
gs-4426	188	3	emerging	emerge	VERB
gs-4426	188	4	areas	area	NOUN
gs-4426	188	5	including	include	VERB
gs-4426	188	6	cardiovascular	cardiovascular	ADJ
gs-4426	188	7	disease	disease	NOUN
gs-4426	188	8	(	(	PUNCT
gs-4426	188	9	8	8	NUM
gs-4426	188	10	%	%	NOUN
gs-4426	188	11	)	)	PUNCT
gs-4426	188	12	,	,	PUNCT
gs-4426	188	13	autoimmune	autoimmune	ADJ
gs-4426	188	14	disorders	disorder	NOUN
gs-4426	188	15	(	(	PUNCT
gs-4426	188	16	5	5	NUM
gs-4426	188	17	%	%	NOUN
gs-4426	188	18	)	)	PUNCT
gs-4426	188	19	,	,	PUNCT
gs-4426	188	20	and	and	CCONJ
gs-4426	188	21	diabetes	diabetes	NOUN
gs-4426	188	22	(	(	PUNCT
gs-4426	188	23	3	3	NUM
gs-4426	188	24	%	%	NOUN
gs-4426	188	25	)	)	PUNCT
gs-4426	188	26	represent	represent	VERB
gs-4426	188	27	the	the	DET
gs-4426	188	28	field	field	NOUN
gs-4426	188	29	's	's	PART
gs-4426	188	30	expansion	expansion	NOUN
gs-4426	188	31	beyond	beyond	ADP
gs-4426	188	32	traditional	traditional	ADJ
gs-4426	188	33	gene	gene	NOUN
gs-4426	188	34	therapy	therapy	NOUN
gs-4426	188	35	indications	indication	NOUN
gs-4426	188	36	toward	toward	ADP
gs-4426	188	37	more	more	ADJ
gs-4426	188	38	common	common	ADJ
gs-4426	188	39	diseases	disease	NOUN
gs-4426	188	40	affecting	affect	VERB
gs-4426	188	41	larger	large	ADJ
gs-4426	188	42	patient	patient	ADJ
gs-4426	188	43	populations	population	NOUN
gs-4426	188	44	.	.	PUNCT
gs-4426	189	1	the	the	DET
gs-4426	189	2	temporal	temporal	ADJ
gs-4426	189	3	progression	progression	NOUN
gs-4426	189	4	illustrated	illustrate	VERB
gs-4426	189	5	across	across	ADP
gs-4426	189	6	all	all	DET
gs-4426	189	7	three	three	NUM
gs-4426	189	8	panels	panel	NOUN
gs-4426	189	9	demonstrates	demonstrate	VERB
gs-4426	189	10	the	the	DET
gs-4426	189	11	field	field	NOUN
gs-4426	189	12	's	's	PART
gs-4426	189	13	evolution	evolution	NOUN
gs-4426	189	14	from	from	ADP
gs-4426	189	15	a	a	DET
gs-4426	189	16	nascent	nascent	ADJ
gs-4426	189	17	technology	technology	NOUN
gs-4426	189	18	with	with	ADP
gs-4426	189	19	limited	limited	ADJ
gs-4426	189	20	approvals	approval	NOUN
gs-4426	189	21	to	to	ADP
gs-4426	189	22	a	a	DET
gs-4426	189	23	mature	mature	ADJ
gs-4426	189	24	therapeutic	therapeutic	ADJ
gs-4426	189	25	modality	modality	NOUN
gs-4426	189	26	with	with	ADP
gs-4426	189	27	broad	broad	ADJ
gs-4426	189	28	clinical	clinical	ADJ
gs-4426	189	29	applications	application	NOUN
gs-4426	189	30	.	.	PUNCT
gs-4426	190	1	the	the	DET
gs-4426	190	2	increasing	increase	VERB
gs-4426	190	3	number	number	NOUN
gs-4426	190	4	of	of	ADP
gs-4426	190	5	late	late	ADJ
gs-4426	190	6	-	-	PUNCT
gs-4426	190	7	stage	stage	NOUN
gs-4426	190	8	trials	trial	NOUN
gs-4426	190	9	and	and	CCONJ
gs-4426	190	10	regulatory	regulatory	ADJ
gs-4426	190	11	approvals	approval	NOUN
gs-4426	190	12	validates	validate	VERB
gs-4426	190	13	the	the	DET
gs-4426	190	14	scientific	scientific	ADJ
gs-4426	190	15	foundation	foundation	NOUN
gs-4426	190	16	established	establish	VERB
gs-4426	190	17	through	through	ADP
gs-4426	190	18	decades	decade	NOUN
gs-4426	190	19	of	of	ADP
gs-4426	190	20	basic	basic	ADJ
gs-4426	190	21	research	research	NOUN
gs-4426	190	22	and	and	CCONJ
gs-4426	190	23	early	early	ADJ
gs-4426	190	24	clinical	clinical	ADJ
gs-4426	190	25	development	development	NOUN
gs-4426	190	26	.	.	PUNCT
gs-4426	191	1	the	the	DET
gs-4426	191	2	diversification	diversification	NOUN
gs-4426	191	3	into	into	ADP
gs-4426	191	4	new	new	ADJ
gs-4426	191	5	disease	disease	NOUN
gs-4426	191	6	areas	area	NOUN
gs-4426	191	7	reflects	reflect	VERB
gs-4426	191	8	both	both	DET
gs-4426	191	9	technological	technological	ADJ
gs-4426	191	10	advances	advance	NOUN
gs-4426	191	11	enabling	enable	VERB
gs-4426	191	12	treatment	treatment	NOUN
gs-4426	191	13	of	of	ADP
gs-4426	191	14	previously	previously	ADV
gs-4426	191	15	intractable	intractable	ADJ
gs-4426	191	16	conditions	condition	NOUN
gs-4426	191	17	and	and	CCONJ
gs-4426	191	18	industry	industry	NOUN
gs-4426	191	19	confidence	confidence	NOUN
gs-4426	191	20	in	in	ADP
gs-4426	191	21	the	the	DET
gs-4426	191	22	commercial	commercial	ADJ
gs-4426	191	23	viability	viability	NOUN
gs-4426	191	24	of	of	ADP
gs-4426	191	25	gene	gene	NOUN
gs-4426	191	26	therapy	therapy	NOUN
gs-4426	191	27	approaches	approach	VERB
gs-4426	191	28	.	.	PUNCT
gs-4426	192	1	this	this	DET
gs-4426	192	2	figure	figure	NOUN
gs-4426	192	3	collectively	collectively	ADV
gs-4426	192	4	demonstrates	demonstrate	VERB
gs-4426	192	5	that	that	SCONJ
gs-4426	192	6	gene	gene	NOUN
gs-4426	192	7	therapy	therapy	NOUN
gs-4426	192	8	has	have	AUX
gs-4426	192	9	transitioned	transition	VERB
gs-4426	192	10	from	from	ADP
gs-4426	192	11	experimental	experimental	ADJ
gs-4426	192	12	promise	promise	NOUN
gs-4426	192	13	to	to	ADP
gs-4426	192	14	clinical	clinical	ADJ
gs-4426	192	15	reality	reality	NOUN
gs-4426	192	16	,	,	PUNCT
gs-4426	192	17	with	with	ADP
gs-4426	192	18	a	a	DET
gs-4426	192	19	robust	robust	ADJ
gs-4426	192	20	and	and	CCONJ
gs-4426	192	21	diversifying	diversify	VERB
gs-4426	192	22	pipeline	pipeline	NOUN
gs-4426	192	23	positioned	position	VERB
gs-4426	192	24	to	to	PART
gs-4426	192	25	address	address	VERB
gs-4426	192	26	an	an	DET
gs-4426	192	27	expanding	expand	VERB
gs-4426	192	28	range	range	NOUN
gs-4426	192	29	of	of	ADP
gs-4426	192	30	human	human	ADJ
gs-4426	192	31	diseases	disease	NOUN
gs-4426	192	32	.	.	PUNCT
gs-4426	193	1	the	the	DET
gs-4426	193	2	data	datum	NOUN
gs-4426	193	3	support	support	NOUN
gs-4426	193	4	projections	projection	NOUN
gs-4426	193	5	of	of	ADP
gs-4426	193	6	10	10	NUM
gs-4426	193	7	-	-	SYM
gs-4426	193	8	20	20	NUM
gs-4426	193	9	annual	annual	ADJ
gs-4426	193	10	gene	gene	NOUN
gs-4426	193	11	therapy	therapy	NOUN
gs-4426	193	12	approvals	approval	NOUN
gs-4426	193	13	through	through	ADP
gs-4426	193	14	2025	2025	NUM
gs-4426	193	15	and	and	CCONJ
gs-4426	193	16	beyond	beyond	ADP
gs-4426	193	17	,	,	PUNCT
gs-4426	193	18	potentially	potentially	ADV
gs-4426	193	19	impacting	impact	VERB
gs-4426	193	20	millions	million	NOUN
gs-4426	193	21	of	of	ADP
gs-4426	193	22	patients	patient	NOUN
gs-4426	193	23	across	across	ADP
gs-4426	193	24	diverse	diverse	ADJ
gs-4426	193	25	therapeutic	therapeutic	ADJ
gs-4426	193	26	areas	area	NOUN
gs-4426	193	27	.	.	PUNCT
gs-4426	194	1	georgian	georgian	NOUN
gs-4426	194	2	scientists/	scientists/	NUM
gs-4426	194	3	.	.	PUNCT
gs-4426	195	1	7	7	NUM
gs-4426	195	2	n	n	DET
gs-4426	195	3	4	4	NUM
gs-4426	195	4	,	,	PUNCT
gs-4426	195	5	2025	2025	NUM
gs-4426	195	6	608	608	NUM
gs-4426	195	7	figure	figure	NOUN
gs-4426	195	8	3	3	NUM
gs-4426	195	9	:	:	PUNCT
gs-4426	195	10	gene	gene	NOUN
gs-4426	195	11	therapy	therapy	NOUN
gs-4426	195	12	delivery	delivery	NOUN
gs-4426	195	13	platforms	platform	NOUN
gs-4426	195	14	and	and	CCONJ
gs-4426	195	15	molecular	molecular	ADJ
gs-4426	195	16	mechanisms	mechanism	NOUN
gs-4426	195	17	figure	figure	VERB
gs-4426	195	18	3	3	NUM
gs-4426	195	19	provides	provide	VERB
gs-4426	195	20	a	a	DET
gs-4426	195	21	comprehensive	comprehensive	ADJ
gs-4426	195	22	overview	overview	NOUN
gs-4426	195	23	of	of	ADP
gs-4426	195	24	the	the	DET
gs-4426	195	25	principal	principal	ADJ
gs-4426	195	26	gene	gene	NOUN
gs-4426	195	27	therapy	therapy	NOUN
gs-4426	195	28	delivery	delivery	NOUN
gs-4426	195	29	strategies	strategy	NOUN
gs-4426	195	30	and	and	CCONJ
gs-4426	195	31	their	their	PRON
gs-4426	195	32	molecular	molecular	ADJ
gs-4426	195	33	mechanisms	mechanism	NOUN
gs-4426	195	34	,	,	PUNCT
gs-4426	195	35	illustrating	illustrate	VERB
gs-4426	195	36	the	the	DET
gs-4426	195	37	fundamental	fundamental	ADJ
gs-4426	195	38	approaches	approach	NOUN
gs-4426	195	39	that	that	PRON
gs-4426	195	40	have	have	AUX
gs-4426	195	41	enabled	enable	VERB
gs-4426	195	42	clinical	clinical	ADJ
gs-4426	195	43	translation	translation	NOUN
gs-4426	195	44	of	of	ADP
gs-4426	195	45	gene	gene	NOUN
gs-4426	195	46	-	-	PUNCT
gs-4426	195	47	based	base	VERB
gs-4426	195	48	therapeutics	therapeutic	NOUN
gs-4426	195	49	.	.	PUNCT
gs-4426	196	1	the	the	DET
gs-4426	196	2	figure	figure	NOUN
gs-4426	196	3	is	be	AUX
gs-4426	196	4	divided	divide	VERB
gs-4426	196	5	into	into	ADP
gs-4426	196	6	strategic	strategic	ADJ
gs-4426	196	7	workflows	workflow	NOUN
gs-4426	196	8	(	(	PUNCT
gs-4426	196	9	ex	ex	X
gs-4426	196	10	vivo	vivo	NOUN
gs-4426	196	11	and	and	CCONJ
gs-4426	196	12	in	in	ADP
gs-4426	196	13	vivo	vivo	ADJ
gs-4426	196	14	approaches	approach	NOUN
gs-4426	196	15	)	)	PUNCT
gs-4426	196	16	and	and	CCONJ
gs-4426	196	17	mechanistic	mechanistic	ADJ
gs-4426	196	18	detail	detail	NOUN
gs-4426	196	19	(	(	PUNCT
gs-4426	196	20	crispr	crispr	ADJ
gs-4426	196	21	editing	editing	NOUN
gs-4426	196	22	)	)	PUNCT
gs-4426	196	23	,	,	PUNCT
gs-4426	196	24	with	with	ADP
gs-4426	196	25	a	a	DET
gs-4426	196	26	comparative	comparative	ADJ
gs-4426	196	27	analysis	analysis	NOUN
gs-4426	196	28	of	of	ADP
gs-4426	196	29	delivery	delivery	NOUN
gs-4426	196	30	platforms	platform	NOUN
gs-4426	196	31	at	at	ADP
gs-4426	196	32	the	the	DET
gs-4426	196	33	bottom	bottom	NOUN
gs-4426	196	34	.	.	PUNCT
gs-4426	197	1	the	the	DET
gs-4426	197	2	left	left	ADJ
gs-4426	197	3	panel	panel	NOUN
gs-4426	197	4	depicts	depict	VERB
gs-4426	197	5	the	the	DET
gs-4426	197	6	ex	ex	ADJ
gs-4426	197	7	vivo	vivo	NOUN
gs-4426	197	8	gene	gene	NOUN
gs-4426	197	9	therapy	therapy	NOUN
gs-4426	197	10	workflow	workflow	NOUN
gs-4426	197	11	,	,	PUNCT
gs-4426	197	12	which	which	PRON
gs-4426	197	13	has	have	AUX
gs-4426	197	14	proven	prove	VERB
gs-4426	197	15	highly	highly	ADV
gs-4426	197	16	successful	successful	ADJ
gs-4426	197	17	for	for	ADP
gs-4426	197	18	car	car	NOUN
gs-4426	197	19	-	-	PUNCT
gs-4426	197	20	t	t	NOUN
gs-4426	197	21	cell	cell	NOUN
gs-4426	197	22	therapies	therapy	NOUN
gs-4426	197	23	and	and	CCONJ
gs-4426	197	24	hematopoietic	hematopoietic	ADJ
gs-4426	197	25	stem	stem	NOUN
gs-4426	197	26	cell	cell	NOUN
gs-4426	197	27	(	(	PUNCT
gs-4426	197	28	hsc	hsc	NOUN
gs-4426	197	29	)	)	PUNCT
gs-4426	197	30	gene	gene	NOUN
gs-4426	197	31	therapy	therapy	NOUN
gs-4426	197	32	.	.	PUNCT
gs-4426	198	1	this	this	DET
gs-4426	198	2	approach	approach	NOUN
gs-4426	198	3	involves	involve	VERB
gs-4426	198	4	four	four	NUM
gs-4426	198	5	critical	critical	ADJ
gs-4426	198	6	steps	step	NOUN
gs-4426	198	7	:	:	PUNCT
gs-4426	198	8	(	(	PUNCT
gs-4426	198	9	1	1	X
gs-4426	198	10	)	)	PUNCT
gs-4426	198	11	collection	collection	NOUN
gs-4426	198	12	of	of	ADP
gs-4426	198	13	autologous	autologous	ADJ
gs-4426	198	14	cells	cell	NOUN
gs-4426	198	15	from	from	ADP
gs-4426	198	16	the	the	DET
gs-4426	198	17	patient	patient	NOUN
gs-4426	198	18	through	through	ADP
gs-4426	198	19	leukapheresis	leukapheresis	NOUN
gs-4426	198	20	or	or	CCONJ
gs-4426	198	21	bone	bone	NOUN
gs-4426	198	22	marrow	marrow	NOUN
gs-4426	198	23	aspiration	aspiration	NOUN
gs-4426	198	24	,	,	PUNCT
gs-4426	198	25	(	(	PUNCT
gs-4426	198	26	2	2	X
gs-4426	198	27	)	)	PUNCT
gs-4426	198	28	ex	ex	PRON
gs-4426	198	29	vivo	vivo	ADJ
gs-4426	198	30	genetic	genetic	ADJ
gs-4426	198	31	modification	modification	NOUN
gs-4426	198	32	in	in	ADP
gs-4426	198	33	a	a	DET
gs-4426	198	34	controlled	control	VERB
gs-4426	198	35	laboratory	laboratory	NOUN
gs-4426	198	36	environment	environment	NOUN
gs-4426	198	37	using	use	VERB
gs-4426	198	38	viral	viral	ADJ
gs-4426	198	39	vectors	vector	NOUN
gs-4426	198	40	(	(	PUNCT
gs-4426	198	41	typically	typically	ADV
gs-4426	198	42	lentivirus	lentivirus	NOUN
gs-4426	198	43	)	)	PUNCT
gs-4426	198	44	or	or	CCONJ
gs-4426	198	45	gene	gene	NOUN
gs-4426	198	46	editing	edit	VERB
gs-4426	198	47	technologies	technology	NOUN
gs-4426	198	48	,	,	PUNCT
gs-4426	198	49	(	(	PUNCT
gs-4426	198	50	3	3	X
gs-4426	198	51	)	)	PUNCT
gs-4426	198	52	rigorous	rigorous	ADJ
gs-4426	198	53	quality	quality	NOUN
gs-4426	198	54	control	control	NOUN
gs-4426	198	55	testing	testing	NOUN
gs-4426	198	56	to	to	PART
gs-4426	198	57	verify	verify	VERB
gs-4426	198	58	genetic	genetic	ADJ
gs-4426	198	59	modification	modification	NOUN
gs-4426	198	60	,	,	PUNCT
gs-4426	198	61	cell	cell	NOUN
gs-4426	198	62	viability	viability	NOUN
gs-4426	198	63	,	,	PUNCT
gs-4426	198	64	potency	potency	NOUN
gs-4426	198	65	,	,	PUNCT
gs-4426	198	66	and	and	CCONJ
gs-4426	198	67	absence	absence	NOUN
gs-4426	198	68	of	of	ADP
gs-4426	198	69	contamination	contamination	NOUN
gs-4426	198	70	,	,	PUNCT
gs-4426	198	71	and	and	CCONJ
gs-4426	198	72	(	(	PUNCT
gs-4426	198	73	4	4	X
gs-4426	198	74	)	)	PUNCT
gs-4426	198	75	infusion	infusion	NOUN
gs-4426	198	76	of	of	ADP
gs-4426	198	77	the	the	DET
gs-4426	198	78	modified	modify	VERB
gs-4426	198	79	cells	cell	NOUN
gs-4426	198	80	back	back	ADV
gs-4426	198	81	into	into	ADP
gs-4426	198	82	the	the	DET
gs-4426	198	83	patient	patient	NOUN
gs-4426	198	84	following	follow	VERB
gs-4426	198	85	conditioning	condition	VERB
gs-4426	198	86	regimens	regimen	NOUN
gs-4426	198	87	when	when	SCONJ
gs-4426	198	88	appropriate	appropriate	ADJ
gs-4426	198	89	.	.	PUNCT
gs-4426	199	1	this	this	DET
gs-4426	199	2	ex	ex	PRON
gs-4426	199	3	vivo	vivo	ADJ
gs-4426	199	4	strategy	strategy	NOUN
gs-4426	199	5	offers	offer	VERB
gs-4426	199	6	several	several	ADJ
gs-4426	199	7	advantages	advantage	NOUN
gs-4426	199	8	including	include	VERB
gs-4426	199	9	the	the	DET
gs-4426	199	10	ability	ability	NOUN
gs-4426	199	11	to	to	PART
gs-4426	199	12	perform	perform	VERB
gs-4426	199	13	extensive	extensive	ADJ
gs-4426	199	14	quality	quality	NOUN
gs-4426	199	15	testing	testing	NOUN
gs-4426	199	16	before	before	ADP
gs-4426	199	17	administration	administration	NOUN
gs-4426	199	18	,	,	PUNCT
gs-4426	199	19	precise	precise	ADJ
gs-4426	199	20	control	control	NOUN
gs-4426	199	21	over	over	ADP
gs-4426	199	22	the	the	DET
gs-4426	199	23	modification	modification	NOUN
gs-4426	199	24	process	process	NOUN
gs-4426	199	25	,	,	PUNCT
gs-4426	199	26	and	and	CCONJ
gs-4426	199	27	elimination	elimination	NOUN
gs-4426	199	28	of	of	ADP
gs-4426	199	29	the	the	DET
gs-4426	199	30	need	need	NOUN
gs-4426	199	31	for	for	ADP
gs-4426	199	32	in	in	ADP
gs-4426	199	33	vivo	vivo	ADJ
gs-4426	199	34	vector	vector	NOUN
gs-4426	199	35	targeting	targeting	NOUN
gs-4426	199	36	.	.	PUNCT
gs-4426	200	1	however	however	ADV
gs-4426	200	2	,	,	PUNCT
gs-4426	200	3	it	it	PRON
gs-4426	200	4	requires	require	VERB
gs-4426	200	5	sophisticated	sophisticated	ADJ
gs-4426	200	6	manufacturing	manufacturing	NOUN
gs-4426	200	7	infrastructure	infrastructure	NOUN
gs-4426	200	8	,	,	PUNCT
gs-4426	200	9	involves	involve	VERB
gs-4426	200	10	complex	complex	ADJ
gs-4426	200	11	logistics	logistic	NOUN
gs-4426	200	12	,	,	PUNCT
gs-4426	200	13	and	and	CCONJ
gs-4426	200	14	is	be	AUX
gs-4426	200	15	limited	limit	VERB
gs-4426	200	16	to	to	ADP
gs-4426	200	17	cell	cell	NOUN
gs-4426	200	18	types	type	NOUN
gs-4426	200	19	that	that	PRON
gs-4426	200	20	can	can	AUX
gs-4426	200	21	be	be	AUX
gs-4426	200	22	isolated	isolate	VERB
gs-4426	200	23	,	,	PUNCT
gs-4426	200	24	manipulated	manipulate	VERB
gs-4426	200	25	ex	ex	PRON
gs-4426	200	26	vivo	vivo	NOUN
gs-4426	200	27	,	,	PUNCT
gs-4426	200	28	and	and	CCONJ
gs-4426	200	29	successfully	successfully	ADV
gs-4426	200	30	engrafted	engraft	VERB
gs-4426	200	31	.	.	PUNCT
gs-4426	201	1	the	the	DET
gs-4426	201	2	success	success	NOUN
gs-4426	201	3	of	of	ADP
gs-4426	201	4	car	car	NOUN
gs-4426	201	5	-	-	PUNCT
gs-4426	201	6	t	t	NOUN
gs-4426	201	7	therapies	therapy	NOUN
gs-4426	201	8	for	for	ADP
gs-4426	201	9	hematological	hematological	ADJ
gs-4426	201	10	malignancies	malignancy	NOUN
gs-4426	201	11	and	and	CCONJ
gs-4426	201	12	genecorrected	genecorrecte	VERB
gs-4426	201	13	hsc	hsc	NOUN
gs-4426	201	14	therapies	therapy	NOUN
gs-4426	201	15	for	for	ADP
gs-4426	201	16	sickle	sickle	NOUN
gs-4426	201	17	cell	cell	NOUN
gs-4426	201	18	disease	disease	NOUN
gs-4426	201	19	exemplifies	exemplify	VERB
gs-4426	201	20	the	the	DET
gs-4426	201	21	clinical	clinical	ADJ
gs-4426	201	22	potential	potential	NOUN
gs-4426	201	23	of	of	ADP
gs-4426	201	24	this	this	DET
gs-4426	201	25	approach	approach	NOUN
gs-4426	201	26	.	.	PUNCT
gs-4426	202	1	the	the	DET
gs-4426	202	2	center	center	NOUN
gs-4426	202	3	panel	panel	NOUN
gs-4426	202	4	illustrates	illustrate	VERB
gs-4426	202	5	in	in	ADP
gs-4426	202	6	vivo	vivo	ADJ
gs-4426	202	7	gene	gene	NOUN
gs-4426	202	8	therapy	therapy	NOUN
gs-4426	202	9	,	,	PUNCT
gs-4426	202	10	which	which	PRON
gs-4426	202	11	delivers	deliver	VERB
gs-4426	202	12	genetic	genetic	ADJ
gs-4426	202	13	material	material	NOUN
gs-4426	202	14	directly	directly	ADV
gs-4426	202	15	to	to	PART
gs-4426	202	16	target	target	VERB
gs-4426	202	17	tissues	tissue	NOUN
gs-4426	202	18	within	within	ADP
gs-4426	202	19	the	the	DET
gs-4426	202	20	patient	patient	NOUN
gs-4426	202	21	's	's	PART
gs-4426	202	22	body	body	NOUN
gs-4426	202	23	.	.	PUNCT
gs-4426	203	1	this	this	DET
gs-4426	203	2	approach	approach	NOUN
gs-4426	203	3	typically	typically	ADV
gs-4426	203	4	employs	employ	VERB
gs-4426	203	5	viral	viral	ADJ
gs-4426	203	6	vectors	vector	NOUN
gs-4426	203	7	,	,	PUNCT
gs-4426	203	8	most	most	ADV
gs-4426	203	9	commonly	commonly	ADV
gs-4426	203	10	adeno	adeno	NOUN
gs-4426	203	11	-	-	PUNCT
gs-4426	203	12	associated	associate	VERB
gs-4426	203	13	virus	virus	NOUN
gs-4426	203	14	(	(	PUNCT
gs-4426	203	15	aav	aav	PROPN
gs-4426	203	16	)	)	PUNCT
gs-4426	203	17	,	,	PUNCT
gs-4426	203	18	which	which	PRON
gs-4426	203	19	are	be	AUX
gs-4426	203	20	administered	administer	VERB
gs-4426	203	21	systemically	systemically	ADV
gs-4426	203	22	via	via	ADP
gs-4426	203	23	intravenous	intravenous	ADJ
gs-4426	203	24	infusion	infusion	NOUN
gs-4426	203	25	or	or	CCONJ
gs-4426	203	26	locally	locally	ADV
gs-4426	203	27	via	via	ADP
gs-4426	203	28	direct	direct	ADJ
gs-4426	203	29	injection	injection	NOUN
gs-4426	203	30	.	.	PUNCT
gs-4426	204	1	the	the	DET
gs-4426	204	2	figure	figure	NOUN
gs-4426	204	3	shows	show	VERB
gs-4426	204	4	aav	aav	NOUN
gs-4426	204	5	vectors	vector	NOUN
gs-4426	204	6	navigating	navigate	VERB
gs-4426	204	7	to	to	AUX
gs-4426	204	8	target	target	VERB
gs-4426	204	9	organs	organ	NOUN
gs-4426	204	10	—	—	PUNCT
gs-4426	204	11	liver	liver	NOUN
gs-4426	204	12	,	,	PUNCT
gs-4426	204	13	muscle	muscle	NOUN
gs-4426	204	14	,	,	PUNCT
gs-4426	204	15	and	and	CCONJ
gs-4426	204	16	eye	eye	NOUN
gs-4426	204	17	—	—	PUNCT
gs-4426	204	18	which	which	PRON
gs-4426	204	19	represent	represent	VERB
gs-4426	204	20	the	the	DET
gs-4426	204	21	most	most	ADV
gs-4426	204	22	successfully	successfully	ADV
gs-4426	204	23	targeted	target	VERB
gs-4426	204	24	tissues	tissue	NOUN
gs-4426	204	25	to	to	ADP
gs-4426	204	26	date	date	NOUN
gs-4426	204	27	.	.	PUNCT
gs-4426	205	1	upon	upon	SCONJ
gs-4426	205	2	reaching	reach	VERB
gs-4426	205	3	target	target	NOUN
gs-4426	205	4	cells	cell	NOUN
gs-4426	205	5	,	,	PUNCT
gs-4426	205	6	aav	aav	NOUN
gs-4426	205	7	vectors	vector	NOUN
gs-4426	205	8	undergo	undergo	VERB
gs-4426	205	9	cellular	cellular	ADJ
gs-4426	205	10	uptake	uptake	NOUN
gs-4426	205	11	,	,	PUNCT
gs-4426	205	12	nuclear	nuclear	ADJ
gs-4426	205	13	translocation	translocation	NOUN
gs-4426	205	14	,	,	PUNCT
gs-4426	205	15	and	and	CCONJ
gs-4426	205	16	transgene	transgene	ADJ
gs-4426	205	17	expression	expression	NOUN
gs-4426	205	18	,	,	PUNCT
gs-4426	205	19	resulting	result	VERB
gs-4426	205	20	in	in	ADP
gs-4426	205	21	sustained	sustained	ADJ
gs-4426	205	22	production	production	NOUN
gs-4426	205	23	of	of	ADP
gs-4426	205	24	the	the	DET
gs-4426	205	25	therapeutic	therapeutic	ADJ
gs-4426	205	26	protein	protein	NOUN
gs-4426	205	27	.	.	PUNCT
gs-4426	206	1	in	in	ADP
gs-4426	206	2	vivo	vivo	ADJ
gs-4426	206	3	gene	gene	NOUN
gs-4426	206	4	therapy	therapy	NOUN
gs-4426	206	5	offers	offer	VERB
gs-4426	206	6	the	the	DET
gs-4426	206	7	advantage	advantage	NOUN
gs-4426	206	8	of	of	ADP
gs-4426	206	9	treating	treat	VERB
gs-4426	206	10	tissues	tissue	NOUN
gs-4426	206	11	that	that	PRON
gs-4426	206	12	can	can	AUX
gs-4426	206	13	not	not	PART
gs-4426	206	14	be	be	AUX
gs-4426	206	15	easily	easily	ADV
gs-4426	206	16	harvested	harvest	VERB
gs-4426	206	17	and	and	CCONJ
gs-4426	206	18	manipulated	manipulate	VERB
gs-4426	206	19	ex	ex	PRON
gs-4426	206	20	vivo	vivo	NOUN
gs-4426	206	21	,	,	PUNCT
gs-4426	206	22	particularly	particularly	ADV
gs-4426	206	23	solid	solid	ADJ
gs-4426	206	24	organs	organ	NOUN
gs-4426	206	25	.	.	PUNCT
gs-4426	207	1	the	the	DET
gs-4426	207	2	liver	liver	NOUN
gs-4426	207	3	has	have	AUX
gs-4426	207	4	emerged	emerge	VERB
gs-4426	207	5	as	as	ADP
gs-4426	207	6	an	an	DET
gs-4426	207	7	especially	especially	ADV
gs-4426	207	8	amenable	amenable	ADJ
gs-4426	207	9	target	target	NOUN
gs-4426	207	10	due	due	ADP
gs-4426	207	11	to	to	ADP
gs-4426	207	12	its	its	PRON
gs-4426	207	13	high	high	ADJ
gs-4426	207	14	vascularization	vascularization	NOUN
gs-4426	207	15	,	,	PUNCT
gs-4426	207	16	aav	aav	NOUN
gs-4426	207	17	tropism	tropism	NOUN
gs-4426	207	18	,	,	PUNCT
gs-4426	207	19	and	and	CCONJ
gs-4426	207	20	tolerance	tolerance	NOUN
gs-4426	207	21	of	of	ADP
gs-4426	207	22	transgene	transgene	ADJ
gs-4426	207	23	expression	expression	NOUN
gs-4426	207	24	,	,	PUNCT
gs-4426	207	25	as	as	SCONJ
gs-4426	207	26	demonstrated	demonstrate	VERB
gs-4426	207	27	by	by	ADP
gs-4426	207	28	approved	approve	VERB
gs-4426	207	29	therapies	therapy	NOUN
gs-4426	207	30	for	for	ADP
gs-4426	207	31	georgian	georgian	NOUN
gs-4426	207	32	scientists/	scientists/	NUM
gs-4426	207	33	.	.	PUNCT
gs-4426	208	1	7	7	NUM
gs-4426	208	2	n	n	DET
gs-4426	208	3	4	4	NUM
gs-4426	208	4	,	,	PUNCT
gs-4426	208	5	2025	2025	NUM
gs-4426	208	6	609	609	NUM
gs-4426	208	7	hemophilia	hemophilia	NOUN
gs-4426	208	8	and	and	CCONJ
gs-4426	208	9	ongoing	ongoing	ADJ
gs-4426	208	10	trials	trial	NOUN
gs-4426	208	11	for	for	ADP
gs-4426	208	12	metabolic	metabolic	NOUN
gs-4426	208	13	disorders	disorder	NOUN
gs-4426	208	14	.	.	PUNCT
gs-4426	209	1	however	however	ADV
gs-4426	209	2	,	,	PUNCT
gs-4426	209	3	in	in	ADP
gs-4426	209	4	vivo	vivo	ADJ
gs-4426	209	5	delivery	delivery	NOUN
gs-4426	209	6	faces	face	VERB
gs-4426	209	7	challenges	challenge	NOUN
gs-4426	209	8	including	include	VERB
gs-4426	209	9	pre	pre	ADJ
gs-4426	209	10	-	-	ADJ
gs-4426	209	11	existing	exist	VERB
gs-4426	209	12	neutralizing	neutralizing	ADJ
gs-4426	209	13	antibodies	antibody	NOUN
gs-4426	209	14	in	in	ADP
gs-4426	209	15	up	up	ADP
gs-4426	209	16	to	to	PART
gs-4426	209	17	50	50	NUM
gs-4426	209	18	%	%	NOUN
gs-4426	209	19	of	of	ADP
gs-4426	209	20	the	the	DET
gs-4426	209	21	population	population	NOUN
gs-4426	209	22	for	for	ADP
gs-4426	209	23	common	common	ADJ
gs-4426	209	24	aav	aav	NOUN
gs-4426	209	25	serotypes	serotype	NOUN
gs-4426	209	26	,	,	PUNCT
gs-4426	209	27	potential	potential	ADJ
gs-4426	209	28	immune	immune	ADJ
gs-4426	209	29	responses	response	NOUN
gs-4426	209	30	to	to	ADP
gs-4426	209	31	vector	vector	NOUN
gs-4426	209	32	capsids	capsid	NOUN
gs-4426	209	33	or	or	CCONJ
gs-4426	209	34	transgene	transgene	ADJ
gs-4426	209	35	products	product	NOUN
gs-4426	209	36	,	,	PUNCT
gs-4426	209	37	limited	limited	ADJ
gs-4426	209	38	ability	ability	NOUN
gs-4426	209	39	for	for	ADP
gs-4426	209	40	repeat	repeat	NOUN
gs-4426	209	41	dosing	dose	VERB
gs-4426	209	42	with	with	ADP
gs-4426	209	43	the	the	DET
gs-4426	209	44	same	same	ADJ
gs-4426	209	45	serotype	serotype	NOUN
gs-4426	209	46	,	,	PUNCT
gs-4426	209	47	and	and	CCONJ
gs-4426	209	48	difficulty	difficulty	NOUN
gs-4426	209	49	achieving	achieve	VERB
gs-4426	209	50	uniform	uniform	ADJ
gs-4426	209	51	tissue	tissue	NOUN
gs-4426	209	52	distribution	distribution	NOUN
gs-4426	209	53	in	in	ADP
gs-4426	209	54	some	some	DET
gs-4426	209	55	organs	organ	NOUN
gs-4426	209	56	.	.	PUNCT
gs-4426	210	1	the	the	DET
gs-4426	210	2	right	right	ADJ
gs-4426	210	3	panel	panel	NOUN
gs-4426	210	4	details	detail	VERB
gs-4426	210	5	the	the	DET
gs-4426	210	6	crispr	crispr	ADJ
gs-4426	210	7	-	-	PUNCT
gs-4426	210	8	cas9	cas9	NOUN
gs-4426	210	9	gene	gene	NOUN
gs-4426	210	10	editing	edit	VERB
gs-4426	210	11	mechanism	mechanism	NOUN
gs-4426	210	12	,	,	PUNCT
gs-4426	210	13	which	which	PRON
gs-4426	210	14	has	have	AUX
gs-4426	210	15	revolutionized	revolutionize	VERB
gs-4426	210	16	gene	gene	NOUN
gs-4426	210	17	therapy	therapy	NOUN
gs-4426	210	18	by	by	ADP
gs-4426	210	19	enabling	enable	VERB
gs-4426	210	20	precise	precise	ADJ
gs-4426	210	21	genomic	genomic	ADJ
gs-4426	210	22	modifications	modification	NOUN
gs-4426	210	23	rather	rather	ADV
gs-4426	210	24	than	than	ADP
gs-4426	210	25	simple	simple	ADJ
gs-4426	210	26	gene	gene	NOUN
gs-4426	210	27	addition	addition	NOUN
gs-4426	210	28	.	.	PUNCT
gs-4426	211	1	the	the	DET
gs-4426	211	2	figure	figure	NOUN
gs-4426	211	3	illustrates	illustrate	VERB
gs-4426	211	4	the	the	DET
gs-4426	211	5	key	key	ADJ
gs-4426	211	6	components	component	NOUN
gs-4426	211	7	and	and	CCONJ
gs-4426	211	8	steps	step	NOUN
gs-4426	211	9	:	:	PUNCT
gs-4426	211	10	(	(	PUNCT
gs-4426	211	11	1	1	X
gs-4426	211	12	)	)	PUNCT
gs-4426	211	13	the	the	DET
gs-4426	211	14	cas9	cas9	NOUN
gs-4426	211	15	endonuclease	endonuclease	NOUN
gs-4426	211	16	protein	protein	NOUN
gs-4426	211	17	complexes	complexe	VERB
gs-4426	211	18	with	with	ADP
gs-4426	211	19	a	a	DET
gs-4426	211	20	guide	guide	NOUN
gs-4426	211	21	rna	rna	NOUN
gs-4426	211	22	(	(	PUNCT
gs-4426	211	23	grna	grna	NOUN
gs-4426	211	24	)	)	PUNCT
gs-4426	211	25	that	that	PRON
gs-4426	211	26	directs	direct	VERB
gs-4426	211	27	sequence	sequence	NOUN
gs-4426	211	28	-	-	PUNCT
gs-4426	211	29	specific	specific	ADJ
gs-4426	211	30	dna	dna	NOUN
gs-4426	211	31	recognition	recognition	NOUN
gs-4426	211	32	,	,	PUNCT
gs-4426	211	33	(	(	PUNCT
gs-4426	211	34	2	2	X
gs-4426	211	35	)	)	PUNCT
gs-4426	211	36	target	target	NOUN
gs-4426	211	37	site	site	NOUN
gs-4426	211	38	identification	identification	NOUN
gs-4426	211	39	through	through	ADP
gs-4426	211	40	complementary	complementary	ADJ
gs-4426	211	41	base	base	NOUN
gs-4426	211	42	pairing	pair	VERB
gs-4426	211	43	between	between	ADP
gs-4426	211	44	the	the	DET
gs-4426	211	45	grna	grna	NOUN
gs-4426	211	46	and	and	CCONJ
gs-4426	211	47	genomic	genomic	ADJ
gs-4426	211	48	dna	dna	NOUN
gs-4426	211	49	,	,	PUNCT
gs-4426	211	50	(	(	PUNCT
gs-4426	211	51	3	3	X
gs-4426	211	52	)	)	PUNCT
gs-4426	211	53	cas9	cas9	NOUN
gs-4426	211	54	-	-	PUNCT
gs-4426	211	55	mediated	mediate	VERB
gs-4426	212	1	doublestrand	doublestrand	NOUN
gs-4426	212	2	break	break	VERB
gs-4426	212	3	formation	formation	NOUN
gs-4426	212	4	at	at	ADP
gs-4426	212	5	the	the	DET
gs-4426	212	6	target	target	NOUN
gs-4426	212	7	locus	locus	NOUN
gs-4426	212	8	,	,	PUNCT
gs-4426	212	9	and	and	CCONJ
gs-4426	212	10	(	(	PUNCT
gs-4426	212	11	4	4	X
gs-4426	212	12	)	)	PUNCT
gs-4426	212	13	cellular	cellular	ADJ
gs-4426	212	14	dna	dna	NOUN
gs-4426	212	15	repair	repair	NOUN
gs-4426	212	16	processes	process	NOUN
gs-4426	212	17	that	that	PRON
gs-4426	212	18	can	can	AUX
gs-4426	212	19	be	be	AUX
gs-4426	212	20	harnessed	harness	VERB
gs-4426	212	21	to	to	PART
gs-4426	212	22	achieve	achieve	VERB
gs-4426	212	23	gene	gene	NOUN
gs-4426	212	24	knockout	knockout	NOUN
gs-4426	212	25	(	(	PUNCT
gs-4426	212	26	via	via	ADP
gs-4426	212	27	non	non	ADJ
gs-4426	212	28	-	-	ADJ
gs-4426	212	29	homologous	homologous	ADJ
gs-4426	212	30	end	end	NOUN
gs-4426	212	31	joining	join	VERB
gs-4426	212	32	)	)	PUNCT
gs-4426	212	33	or	or	CCONJ
gs-4426	212	34	precise	precise	ADJ
gs-4426	212	35	gene	gene	NOUN
gs-4426	212	36	correction	correction	NOUN
gs-4426	212	37	(	(	PUNCT
gs-4426	212	38	via	via	ADP
gs-4426	212	39	homology	homology	NOUN
gs-4426	212	40	-	-	PUNCT
gs-4426	212	41	directed	direct	VERB
gs-4426	212	42	repair	repair	NOUN
gs-4426	212	43	when	when	SCONJ
gs-4426	212	44	a	a	DET
gs-4426	212	45	dna	dna	NOUN
gs-4426	212	46	template	template	NOUN
gs-4426	212	47	is	be	AUX
gs-4426	212	48	provided	provide	VERB
gs-4426	212	49	)	)	PUNCT
gs-4426	212	50	.	.	PUNCT
gs-4426	213	1	the	the	PRON
gs-4426	213	2	"	"	PUNCT
gs-4426	213	3	before	before	ADP
gs-4426	213	4	and	and	CCONJ
gs-4426	213	5	after	after	ADP
gs-4426	213	6	"	"	PUNCT
gs-4426	213	7	representation	representation	NOUN
gs-4426	213	8	emphasizes	emphasize	VERB
gs-4426	213	9	crispr	crispr	NOUN
gs-4426	213	10	's	's	PART
gs-4426	213	11	ability	ability	NOUN
gs-4426	213	12	to	to	PART
gs-4426	213	13	correct	correct	VERB
gs-4426	213	14	disease	disease	NOUN
gs-4426	213	15	-	-	PUNCT
gs-4426	213	16	causing	cause	VERB
gs-4426	213	17	mutations	mutation	NOUN
gs-4426	213	18	at	at	ADP
gs-4426	213	19	their	their	PRON
gs-4426	213	20	genomic	genomic	ADJ
gs-4426	213	21	location	location	NOUN
gs-4426	213	22	,	,	PUNCT
gs-4426	213	23	offering	offer	VERB
gs-4426	213	24	potential	potential	NOUN
gs-4426	213	25	for	for	ADP
gs-4426	213	26	true	true	ADJ
gs-4426	213	27	cures	cure	NOUN
gs-4426	213	28	rather	rather	ADV
gs-4426	213	29	than	than	ADP
gs-4426	213	30	symptom	symptom	NOUN
gs-4426	213	31	management	management	NOUN
gs-4426	213	32	.	.	PUNCT
gs-4426	214	1	this	this	DET
gs-4426	214	2	technology	technology	NOUN
gs-4426	214	3	has	have	AUX
gs-4426	214	4	enabled	enable	VERB
gs-4426	214	5	clinical	clinical	ADJ
gs-4426	214	6	successes	success	NOUN
gs-4426	214	7	such	such	ADJ
gs-4426	214	8	as	as	ADP
gs-4426	214	9	casgevy	casgevy	NOUN
gs-4426	214	10	for	for	ADP
gs-4426	214	11	sickle	sickle	NOUN
gs-4426	214	12	cell	cell	NOUN
gs-4426	214	13	disease	disease	NOUN
gs-4426	214	14	and	and	CCONJ
gs-4426	214	15	beta	beta	NOUN
gs-4426	214	16	thalassemia	thalassemia	NOUN
gs-4426	214	17	,	,	PUNCT
gs-4426	214	18	while	while	SCONJ
gs-4426	214	19	ongoing	ongoing	ADJ
gs-4426	214	20	trials	trial	NOUN
gs-4426	214	21	explore	explore	VERB
gs-4426	214	22	applications	application	NOUN
gs-4426	214	23	in	in	ADP
gs-4426	214	24	cardiovascular	cardiovascular	ADJ
gs-4426	214	25	disease	disease	NOUN
gs-4426	214	26	,	,	PUNCT
gs-4426	214	27	diabetes	diabetes	NOUN
gs-4426	214	28	,	,	PUNCT
gs-4426	214	29	and	and	CCONJ
gs-4426	214	30	infectious	infectious	ADJ
gs-4426	214	31	diseases	disease	NOUN
gs-4426	214	32	.	.	PUNCT
gs-4426	215	1	advanced	advanced	ADJ
gs-4426	215	2	crispr	crispr	ADJ
gs-4426	215	3	variants	variant	NOUN
gs-4426	215	4	including	include	VERB
gs-4426	215	5	base	base	NOUN
gs-4426	215	6	editors	editor	NOUN
gs-4426	215	7	and	and	CCONJ
gs-4426	215	8	prime	prime	ADJ
gs-4426	215	9	editors	editor	NOUN
gs-4426	215	10	,	,	PUNCT
gs-4426	215	11	which	which	PRON
gs-4426	215	12	enable	enable	VERB
gs-4426	215	13	nucleotide	nucleotide	NOUN
gs-4426	215	14	-	-	PUNCT
gs-4426	215	15	level	level	NOUN
gs-4426	215	16	changes	change	NOUN
gs-4426	215	17	without	without	ADP
gs-4426	215	18	double	double	ADJ
gs-4426	215	19	figure	figure	NOUN
gs-4426	215	20	4	4	NUM
gs-4426	215	21	.	.	PUNCT
gs-4426	215	22	fda	fda	PROPN
gs-4426	215	23	-	-	PUNCT
gs-4426	215	24	approved	approve	VERB
gs-4426	215	25	gene	gene	NOUN
gs-4426	215	26	therapies	therapy	NOUN
gs-4426	215	27	in	in	ADP
gs-4426	215	28	2024	2024	NUM
gs-4426	215	29	:	:	PUNCT
gs-4426	215	30	key	key	ADJ
gs-4426	215	31	characteristics	characteristic	NOUN
gs-4426	215	32	and	and	CCONJ
gs-4426	215	33	cost	cost	NOUN
gs-4426	215	34	analysis	analysis	NOUN
gs-4426	215	35	.	.	PUNCT
gs-4426	216	1	summary	summary	NOUN
gs-4426	216	2	of	of	ADP
gs-4426	216	3	seven	seven	NUM
gs-4426	216	4	gene	gene	NOUN
gs-4426	216	5	therapy	therapy	NOUN
gs-4426	216	6	products	product	NOUN
gs-4426	216	7	receiving	receive	VERB
gs-4426	216	8	fda	fda	PROPN
gs-4426	216	9	approval	approval	NOUN
gs-4426	216	10	in	in	ADP
gs-4426	216	11	2024	2024	NUM
gs-4426	216	12	,	,	PUNCT
gs-4426	216	13	including	include	VERB
gs-4426	216	14	product	product	NOUN
gs-4426	216	15	name	name	NOUN
gs-4426	216	16	,	,	PUNCT
gs-4426	216	17	approval	approval	NOUN
gs-4426	216	18	date	date	NOUN
gs-4426	216	19	,	,	PUNCT
gs-4426	216	20	technology	technology	NOUN
gs-4426	216	21	platform	platform	NOUN
gs-4426	216	22	,	,	PUNCT
gs-4426	216	23	therapeutic	therapeutic	ADJ
gs-4426	216	24	indication	indication	NOUN
gs-4426	216	25	,	,	PUNCT
gs-4426	216	26	and	and	CCONJ
gs-4426	216	27	approximate	approximate	ADJ
gs-4426	216	28	cost	cost	NOUN
gs-4426	216	29	per	per	ADP
gs-4426	216	30	treatment	treatment	NOUN
gs-4426	216	31	.	.	PUNCT
gs-4426	217	1	products	product	NOUN
gs-4426	217	2	span	span	VERB
gs-4426	217	3	multiple	multiple	ADJ
gs-4426	217	4	platforms	platform	NOUN
gs-4426	217	5	including	include	VERB
gs-4426	217	6	tumor	tumor	NOUN
gs-4426	217	7	-	-	PUNCT
gs-4426	217	8	infiltrating	infiltrate	VERB
gs-4426	217	9	lymphocyte	lymphocyte	NOUN
gs-4426	217	10	(	(	PUNCT
gs-4426	217	11	til	til	ADJ
gs-4426	217	12	)	)	PUNCT
gs-4426	217	13	therapy	therapy	NOUN
gs-4426	217	14	,	,	PUNCT
gs-4426	217	15	adenoassociated	adenoassociate	VERB
gs-4426	217	16	virus	virus	NOUN
gs-4426	217	17	(	(	PUNCT
gs-4426	217	18	aav	aav	NOUN
gs-4426	217	19	)	)	PUNCT
gs-4426	217	20	gene	gene	NOUN
gs-4426	217	21	therapy	therapy	NOUN
gs-4426	217	22	,	,	PUNCT
gs-4426	217	23	t	t	NOUN
gs-4426	217	24	-	-	PUNCT
gs-4426	217	25	cell	cell	NOUN
gs-4426	217	26	receptor	receptor	NOUN
gs-4426	217	27	(	(	PUNCT
gs-4426	217	28	tcr	tcr	PROPN
gs-4426	217	29	)	)	PUNCT
gs-4426	217	30	therapy	therapy	NOUN
gs-4426	217	31	,	,	PUNCT
gs-4426	217	32	chimeric	chimeric	ADJ
gs-4426	217	33	antigen	antigen	ADJ
gs-4426	217	34	receptor	receptor	NOUN
gs-4426	217	35	tcell	tcell	NOUN
gs-4426	217	36	(	(	PUNCT
gs-4426	217	37	car	car	NOUN
gs-4426	217	38	-	-	PUNCT
gs-4426	217	39	t	t	NOUN
gs-4426	217	40	)	)	PUNCT
gs-4426	217	41	therapy	therapy	NOUN
gs-4426	217	42	,	,	PUNCT
gs-4426	217	43	mesenchymal	mesenchymal	NOUN
gs-4426	217	44	stem	stem	NOUN
gs-4426	217	45	cell	cell	NOUN
gs-4426	217	46	(	(	PUNCT
gs-4426	217	47	msc	msc	NOUN
gs-4426	217	48	)	)	PUNCT
gs-4426	217	49	therapy	therapy	NOUN
gs-4426	217	50	,	,	PUNCT
gs-4426	217	51	and	and	CCONJ
gs-4426	217	52	tissue	tissue	NOUN
gs-4426	217	53	-	-	PUNCT
gs-4426	217	54	engineered	engineer	VERB
gs-4426	217	55	products	product	NOUN
gs-4426	217	56	.	.	PUNCT
gs-4426	218	1	therapeutic	therapeutic	ADJ
gs-4426	218	2	areas	area	NOUN
gs-4426	218	3	include	include	VERB
gs-4426	218	4	cancer	cancer	NOUN
gs-4426	218	5	(	(	PUNCT
gs-4426	218	6	melanoma	melanoma	ADJ
gs-4426	218	7	,	,	PUNCT
gs-4426	218	8	synovial	synovial	ADJ
gs-4426	218	9	sarcoma	sarcoma	NOUN
gs-4426	218	10	and	and	CCONJ
gs-4426	218	11	b	b	NOUN
gs-4426	218	12	-	-	PUNCT
gs-4426	218	13	cell	cell	NOUN
gs-4426	218	14	acute	acute	NOUN
gs-4426	218	15	lymphoblastic	lymphoblastic	ADJ
gs-4426	218	16	georgian	georgian	NOUN
gs-4426	218	17	scientists/	scientists/	NUM
gs-4426	218	18	.	.	PUNCT
gs-4426	219	1	7	7	NUM
gs-4426	219	2	n	n	DET
gs-4426	219	3	4	4	NUM
gs-4426	219	4	,	,	PUNCT
gs-4426	219	5	2025	2025	NUM
gs-4426	219	6	610	610	NUM
gs-4426	219	7	leukemia	leukemia	NOUN
gs-4426	219	8	)	)	PUNCT
gs-4426	219	9	,	,	PUNCT
gs-4426	219	10	blood	blood	NOUN
gs-4426	219	11	disorders	disorder	NOUN
gs-4426	219	12	(	(	PUNCT
gs-4426	219	13	hemophilia	hemophilia	PROPN
gs-4426	219	14	b	b	PROPN
gs-4426	219	15	)	)	PUNCT
gs-4426	219	16	,	,	PUNCT
gs-4426	219	17	rare	rare	ADJ
gs-4426	219	18	genetic	genetic	ADJ
gs-4426	219	19	diseases	disease	NOUN
gs-4426	219	20	(	(	PUNCT
gs-4426	219	21	aadc	aadc	NOUN
gs-4426	219	22	deficiency	deficiency	NOUN
gs-4426	219	23	)	)	PUNCT
gs-4426	219	24	,	,	PUNCT
gs-4426	219	25	inflammatory	inflammatory	ADJ
gs-4426	219	26	conditions	condition	NOUN
gs-4426	219	27	(	(	PUNCT
gs-4426	219	28	graft	graft	NOUN
gs-4426	219	29	-	-	PUNCT
gs-4426	219	30	versus	versus	ADP
gs-4426	219	31	-	-	PUNCT
gs-4426	219	32	host	host	NOUN
gs-4426	219	33	disease	disease	NOUN
gs-4426	219	34	)	)	PUNCT
gs-4426	219	35	,	,	PUNCT
gs-4426	219	36	and	and	CCONJ
gs-4426	219	37	vascular	vascular	ADJ
gs-4426	219	38	applications	application	NOUN
gs-4426	219	39	(	(	PUNCT
gs-4426	219	40	arterial	arterial	NOUN
gs-4426	219	41	injury	injury	NOUN
gs-4426	219	42	)	)	PUNCT
gs-4426	219	43	.	.	PUNCT
gs-4426	220	1	bottom	bottom	ADJ
gs-4426	220	2	panels	panel	NOUN
gs-4426	220	3	summarize	summarize	VERB
gs-4426	220	4	technology	technology	NOUN
gs-4426	220	5	distribution	distribution	NOUN
gs-4426	220	6	,	,	PUNCT
gs-4426	220	7	therapeutic	therapeutic	ADJ
gs-4426	220	8	area	area	NOUN
gs-4426	220	9	coverage	coverage	NOUN
gs-4426	220	10	,	,	PUNCT
gs-4426	220	11	and	and	CCONJ
gs-4426	220	12	key	key	ADJ
gs-4426	220	13	achievements	achievement	NOUN
gs-4426	220	14	including	include	VERB
gs-4426	220	15	four	four	NUM
gs-4426	220	16	first	first	ADJ
gs-4426	220	17	-	-	PUNCT
gs-4426	220	18	in	in	ADP
gs-4426	220	19	-	-	PUNCT
gs-4426	220	20	class	class	NOUN
gs-4426	220	21	approvals	approval	NOUN
gs-4426	220	22	.	.	PUNCT
gs-4426	221	1	pricing	pricing	NOUN
gs-4426	221	2	data	datum	NOUN
gs-4426	221	3	ranges	range	VERB
gs-4426	221	4	from	from	ADP
gs-4426	221	5	$	$	SYM
gs-4426	221	6	15,000	15,000	NUM
gs-4426	221	7	to	to	PART
gs-4426	221	8	$	$	SYM
gs-4426	221	9	4,000,000	4,000,000	NUM
gs-4426	221	10	per	per	ADP
gs-4426	221	11	treatment	treatment	NOUN
gs-4426	221	12	,	,	PUNCT
gs-4426	221	13	highlighting	highlight	VERB
gs-4426	221	14	economic	economic	ADJ
gs-4426	221	15	challenges	challenge	NOUN
gs-4426	221	16	in	in	ADP
gs-4426	221	17	gene	gene	NOUN
gs-4426	221	18	therapy	therapy	NOUN
gs-4426	221	19	accessibility	accessibility	NOUN
gs-4426	221	20	.	.	PUNCT
gs-4426	222	1	all	all	DET
gs-4426	222	2	,	,	PUNCT
gs-4426	222	3	acute	acute	ADJ
gs-4426	222	4	lymphoblastic	lymphoblastic	ADJ
gs-4426	222	5	leukemia	leukemia	NOUN
gs-4426	222	6	;	;	PUNCT
gs-4426	222	7	aadc	aadc	NOUN
gs-4426	222	8	,	,	PUNCT
gs-4426	222	9	aromatic	aromatic	ADJ
gs-4426	222	10	l	l	NOUN
gs-4426	222	11	-	-	ADJ
gs-4426	222	12	amino	amino	ADJ
gs-4426	222	13	acid	acid	NOUN
gs-4426	222	14	decarboxylase	decarboxylase	NOUN
gs-4426	222	15	;	;	PUNCT
gs-4426	222	16	gvhd	gvhd	NOUN
gs-4426	222	17	,	,	PUNCT
gs-4426	222	18	graft	graft	NOUN
gs-4426	222	19	-	-	PUNCT
gs-4426	222	20	versus	versus	ADP
gs-4426	222	21	-	-	PUNCT
gs-4426	222	22	host	host	NOUN
gs-4426	222	23	disease	disease	NOUN
gs-4426	222	24	;	;	PUNCT
gs-4426	222	25	cns	cns	NOUN
gs-4426	222	26	,	,	PUNCT
gs-4426	222	27	central	central	ADJ
gs-4426	222	28	nervous	nervous	ADJ
gs-4426	222	29	system	system	NOUN
gs-4426	222	30	.	.	PUNCT
gs-4426	223	1	data	datum	NOUN
gs-4426	223	2	compiled	compile	VERB
gs-4426	223	3	from	from	ADP
gs-4426	223	4	fda	fda	PROPN
gs-4426	223	5	approval	approval	NOUN
gs-4426	223	6	documents	document	NOUN
gs-4426	223	7	and	and	CCONJ
gs-4426	223	8	company	company	NOUN
gs-4426	223	9	announcements	announcement	NOUN
gs-4426	223	10	.	.	PUNCT
gs-4426	224	1	discussion	discussion	NOUN
gs-4426	224	2	the	the	DET
gs-4426	224	3	remarkable	remarkable	ADJ
gs-4426	224	4	progress	progress	NOUN
gs-4426	224	5	in	in	ADP
gs-4426	224	6	gene	gene	NOUN
gs-4426	224	7	therapy	therapy	NOUN
gs-4426	224	8	over	over	ADP
gs-4426	224	9	the	the	DET
gs-4426	224	10	past	past	ADJ
gs-4426	224	11	decade	decade	NOUN
gs-4426	224	12	,	,	PUNCT
gs-4426	224	13	culminating	culminate	VERB
gs-4426	224	14	in	in	ADP
gs-4426	224	15	multiple	multiple	ADJ
gs-4426	224	16	regulatory	regulatory	ADJ
gs-4426	224	17	approvals	approval	NOUN
gs-4426	224	18	and	and	CCONJ
gs-4426	224	19	expanding	expand	VERB
gs-4426	224	20	clinical	clinical	ADJ
gs-4426	224	21	applications	application	NOUN
gs-4426	224	22	,	,	PUNCT
gs-4426	224	23	represents	represent	VERB
gs-4426	224	24	a	a	DET
gs-4426	224	25	fundamental	fundamental	ADJ
gs-4426	224	26	transformation	transformation	NOUN
gs-4426	224	27	in	in	ADP
gs-4426	224	28	therapeutic	therapeutic	ADJ
gs-4426	224	29	medicine	medicine	NOUN
gs-4426	224	30	.	.	PUNCT
gs-4426	225	1	this	this	DET
gs-4426	225	2	discussion	discussion	NOUN
gs-4426	225	3	synthesizes	synthesize	VERB
gs-4426	225	4	key	key	ADJ
gs-4426	225	5	findings	finding	NOUN
gs-4426	225	6	from	from	ADP
gs-4426	225	7	current	current	ADJ
gs-4426	225	8	gene	gene	NOUN
gs-4426	225	9	therapy	therapy	NOUN
gs-4426	225	10	advances	advance	NOUN
gs-4426	225	11	,	,	PUNCT
gs-4426	225	12	evaluates	evaluate	VERB
gs-4426	225	13	the	the	DET
gs-4426	225	14	translational	translational	ADJ
gs-4426	225	15	significance	significance	NOUN
gs-4426	225	16	of	of	ADP
gs-4426	225	17	recent	recent	ADJ
gs-4426	225	18	developments	development	NOUN
gs-4426	225	19	,	,	PUNCT
gs-4426	225	20	identifies	identify	VERB
gs-4426	225	21	critical	critical	ADJ
gs-4426	225	22	challenges	challenge	NOUN
gs-4426	225	23	requiring	require	VERB
gs-4426	225	24	resolution	resolution	NOUN
gs-4426	225	25	,	,	PUNCT
gs-4426	225	26	and	and	CCONJ
gs-4426	225	27	projects	project	VERB
gs-4426	225	28	future	future	ADJ
gs-4426	225	29	trajectories	trajectory	NOUN
gs-4426	225	30	for	for	ADP
gs-4426	225	31	this	this	DET
gs-4426	225	32	rapidly	rapidly	ADV
gs-4426	225	33	evolving	evolve	VERB
gs-4426	225	34	field	field	NOUN
gs-4426	225	35	.	.	PUNCT
gs-4426	226	1	the	the	DET
gs-4426	226	2	transition	transition	NOUN
gs-4426	226	3	from	from	ADP
gs-4426	226	4	experimental	experimental	ADJ
gs-4426	226	5	concept	concept	NOUN
gs-4426	226	6	to	to	PART
gs-4426	226	7	establish	establish	VERB
gs-4426	226	8	clinical	clinical	ADJ
gs-4426	226	9	modality	modality	NOUN
gs-4426	226	10	,	,	PUNCT
gs-4426	226	11	exemplified	exemplify	VERB
gs-4426	226	12	by	by	ADP
gs-4426	226	13	the	the	DET
gs-4426	226	14	approval	approval	NOUN
gs-4426	226	15	of	of	ADP
gs-4426	226	16	crisprbased	crisprbase	VERB
gs-4426	226	17	therapies	therapy	NOUN
gs-4426	226	18	and	and	CCONJ
gs-4426	226	19	expansion	expansion	NOUN
gs-4426	226	20	of	of	ADP
gs-4426	226	21	car	car	NOUN
gs-4426	226	22	-	-	PUNCT
gs-4426	226	23	t	t	NOUN
gs-4426	226	24	applications	application	NOUN
gs-4426	226	25	beyond	beyond	ADP
gs-4426	226	26	oncology	oncology	NOUN
gs-4426	226	27	,	,	PUNCT
gs-4426	226	28	validates	validate	VERB
gs-4426	226	29	decades	decade	NOUN
gs-4426	226	30	of	of	ADP
gs-4426	226	31	basic	basic	ADJ
gs-4426	226	32	research	research	NOUN
gs-4426	226	33	investment	investment	NOUN
gs-4426	226	34	and	and	CCONJ
gs-4426	226	35	establishes	establish	VERB
gs-4426	226	36	gene	gene	NOUN
gs-4426	226	37	therapy	therapy	NOUN
gs-4426	226	38	as	as	ADP
gs-4426	226	39	a	a	DET
gs-4426	226	40	cornerstone	cornerstone	NOUN
gs-4426	226	41	of	of	ADP
gs-4426	226	42	precision	precision	NOUN
gs-4426	226	43	medicine	medicine	NOUN
gs-4426	226	44	.	.	PUNCT
gs-4426	227	1	however	however	ADV
gs-4426	227	2	,	,	PUNCT
gs-4426	227	3	substantial	substantial	ADJ
gs-4426	227	4	barriers	barrier	NOUN
gs-4426	227	5	including	include	VERB
gs-4426	227	6	manufacturing	manufacturing	NOUN
gs-4426	227	7	limitations	limitation	NOUN
gs-4426	227	8	,	,	PUNCT
gs-4426	227	9	immunological	immunological	ADJ
gs-4426	227	10	challenges	challenge	NOUN
gs-4426	227	11	,	,	PUNCT
gs-4426	227	12	economic	economic	ADJ
gs-4426	227	13	constraints	constraint	NOUN
gs-4426	227	14	,	,	PUNCT
gs-4426	227	15	and	and	CCONJ
gs-4426	227	16	technical	technical	ADJ
gs-4426	227	17	obstacles	obstacle	NOUN
gs-4426	227	18	must	must	AUX
gs-4426	227	19	be	be	AUX
gs-4426	227	20	addressed	address	VERB
gs-4426	227	21	to	to	PART
gs-4426	227	22	realize	realize	VERB
gs-4426	227	23	gene	gene	NOUN
gs-4426	227	24	therapy	therapy	NOUN
gs-4426	227	25	's	's	PART
gs-4426	227	26	full	full	ADJ
gs-4426	227	27	potential	potential	NOUN
gs-4426	227	28	for	for	ADP
gs-4426	227	29	treating	treat	VERB
gs-4426	227	30	diverse	diverse	ADJ
gs-4426	227	31	diseases	disease	NOUN
gs-4426	227	32	and	and	CCONJ
gs-4426	227	33	reaching	reach	VERB
gs-4426	227	34	broad	broad	ADJ
gs-4426	227	35	patient	patient	ADJ
gs-4426	227	36	populations	population	NOUN
gs-4426	227	37	.	.	PUNCT
gs-4426	228	1	the	the	DET
gs-4426	228	2	clinical	clinical	ADJ
gs-4426	228	3	success	success	NOUN
gs-4426	228	4	achieved	achieve	VERB
gs-4426	228	5	in	in	ADP
gs-4426	228	6	monogenic	monogenic	ADJ
gs-4426	228	7	blood	blood	NOUN
gs-4426	228	8	disorders	disorder	NOUN
gs-4426	228	9	demonstrates	demonstrate	VERB
gs-4426	228	10	gene	gene	NOUN
gs-4426	228	11	therapy	therapy	NOUN
gs-4426	228	12	's	's	PART
gs-4426	228	13	capacity	capacity	NOUN
gs-4426	228	14	to	to	PART
gs-4426	228	15	address	address	VERB
gs-4426	228	16	diseases	disease	NOUN
gs-4426	228	17	at	at	ADP
gs-4426	228	18	their	their	PRON
gs-4426	228	19	molecular	molecular	ADJ
gs-4426	228	20	origins	origin	NOUN
gs-4426	228	21	,	,	PUNCT
gs-4426	228	22	offering	offer	VERB
gs-4426	228	23	functional	functional	ADJ
gs-4426	228	24	cures	cure	NOUN
gs-4426	228	25	rather	rather	ADV
gs-4426	228	26	than	than	ADP
gs-4426	228	27	symptomatic	symptomatic	ADJ
gs-4426	228	28	management	management	NOUN
gs-4426	228	29	.	.	PUNCT
gs-4426	229	1	the	the	DET
gs-4426	229	2	dual	dual	ADJ
gs-4426	229	3	approval	approval	NOUN
gs-4426	229	4	of	of	ADP
gs-4426	229	5	casgevy	casgevy	NOUN
gs-4426	229	6	and	and	CCONJ
gs-4426	229	7	lyfgenia	lyfgenia	NOUN
gs-4426	229	8	for	for	ADP
gs-4426	229	9	sickle	sickle	NOUN
gs-4426	229	10	cell	cell	NOUN
gs-4426	229	11	disease	disease	NOUN
gs-4426	229	12	,	,	PUNCT
gs-4426	229	13	employing	employ	VERB
gs-4426	229	14	fundamentally	fundamentally	ADV
gs-4426	229	15	different	different	ADJ
gs-4426	229	16	mechanisms	mechanism	NOUN
gs-4426	229	17	—	—	PUNCT
gs-4426	229	18	crispr	crispr	NOUN
gs-4426	229	19	-	-	PUNCT
gs-4426	229	20	mediated	mediate	VERB
gs-4426	229	21	fetal	fetal	ADJ
gs-4426	229	22	hemoglobin	hemoglobin	NOUN
gs-4426	229	23	reactivation	reactivation	NOUN
gs-4426	229	24	versus	versus	ADP
gs-4426	229	25	lentiviral	lentiviral	ADV
gs-4426	229	26	-	-	PUNCT
gs-4426	229	27	mediated	mediate	VERB
gs-4426	229	28	anti	anti	ADJ
gs-4426	229	29	-	-	ADJ
gs-4426	229	30	sickling	sickling	ADJ
gs-4426	229	31	hemoglobin	hemoglobin	NOUN
gs-4426	229	32	addition	addition	NOUN
gs-4426	229	33	—	—	PUNCT
gs-4426	229	34	validates	validate	VERB
gs-4426	229	35	multiple	multiple	ADJ
gs-4426	229	36	approaches	approach	NOUN
gs-4426	229	37	to	to	ADP
gs-4426	229	38	the	the	DET
gs-4426	229	39	same	same	ADJ
gs-4426	229	40	therapeutic	therapeutic	ADJ
gs-4426	229	41	goal	goal	NOUN
gs-4426	229	42	and	and	CCONJ
gs-4426	229	43	provides	provide	VERB
gs-4426	229	44	physicians	physician	NOUN
gs-4426	229	45	with	with	ADP
gs-4426	229	46	treatment	treatment	NOUN
gs-4426	229	47	options	option	NOUN
gs-4426	229	48	accommodating	accommodate	VERB
gs-4426	229	49	different	different	ADJ
gs-4426	229	50	patient	patient	ADJ
gs-4426	229	51	circumstances	circumstance	NOUN
gs-4426	229	52	and	and	CCONJ
gs-4426	229	53	preferences	preference	NOUN
gs-4426	229	54	.	.	PUNCT
gs-4426	230	1	the	the	DET
gs-4426	230	2	dramatic	dramatic	ADJ
gs-4426	230	3	clinical	clinical	ADJ
gs-4426	230	4	benefits	benefit	NOUN
gs-4426	230	5	observed	observe	VERB
gs-4426	230	6	in	in	ADP
gs-4426	230	7	treated	treat	VERB
gs-4426	230	8	patients	patient	NOUN
gs-4426	230	9	,	,	PUNCT
gs-4426	230	10	including	include	VERB
gs-4426	230	11	complete	complete	ADJ
gs-4426	230	12	elimination	elimination	NOUN
gs-4426	230	13	of	of	ADP
gs-4426	230	14	vaso	vaso	NOUN
gs-4426	230	15	-	-	PUNCT
gs-4426	230	16	occlusive	occlusive	ADJ
gs-4426	230	17	crises	crisis	NOUN
gs-4426	230	18	and	and	CCONJ
gs-4426	230	19	transfusion	transfusion	NOUN
gs-4426	230	20	independence	independence	NOUN
gs-4426	230	21	maintained	maintain	VERB
gs-4426	230	22	through	through	ADP
gs-4426	230	23	multi	multi	ADJ
gs-4426	230	24	-	-	ADJ
gs-4426	230	25	year	year	ADJ
gs-4426	230	26	follow	follow	NOUN
gs-4426	230	27	-	-	PUNCT
gs-4426	230	28	up	up	NOUN
gs-4426	230	29	,	,	PUNCT
gs-4426	230	30	substantiate	substantiate	VERB
gs-4426	230	31	claims	claim	NOUN
gs-4426	230	32	that	that	SCONJ
gs-4426	230	33	these	these	DET
gs-4426	230	34	interventions	intervention	NOUN
gs-4426	230	35	represent	represent	VERB
gs-4426	230	36	curative	curative	ADJ
gs-4426	230	37	therapies	therapy	NOUN
gs-4426	230	38	rather	rather	ADV
gs-4426	230	39	than	than	ADP
gs-4426	230	40	incremental	incremental	ADJ
gs-4426	230	41	improvements	improvement	NOUN
gs-4426	230	42	over	over	ADP
gs-4426	230	43	existing	exist	VERB
gs-4426	230	44	treatments	treatment	NOUN
gs-4426	230	45	.	.	PUNCT
gs-4426	231	1	however	however	ADV
gs-4426	231	2	,	,	PUNCT
gs-4426	231	3	the	the	DET
gs-4426	231	4	limited	limited	ADJ
gs-4426	231	5	numbers	number	NOUN
gs-4426	231	6	of	of	ADP
gs-4426	231	7	patients	patient	NOUN
gs-4426	231	8	treated	treat	VERB
gs-4426	231	9	to	to	ADP
gs-4426	231	10	date	date	NOUN
gs-4426	231	11	,	,	PUNCT
gs-4426	231	12	predominantly	predominantly	ADV
gs-4426	231	13	in	in	ADP
gs-4426	231	14	the	the	DET
gs-4426	231	15	context	context	NOUN
gs-4426	231	16	of	of	ADP
gs-4426	231	17	clinical	clinical	ADJ
gs-4426	231	18	trials	trial	NOUN
gs-4426	231	19	or	or	CCONJ
gs-4426	231	20	early	early	ADJ
gs-4426	231	21	commercial	commercial	ADJ
gs-4426	231	22	experience	experience	NOUN
gs-4426	231	23	,	,	PUNCT
gs-4426	231	24	necessitate	necessitate	ADJ
gs-4426	231	25	continued	continue	VERB
gs-4426	231	26	monitoring	monitoring	NOUN
gs-4426	231	27	to	to	PART
gs-4426	231	28	fully	fully	ADV
gs-4426	231	29	characterize	characterize	VERB
gs-4426	231	30	long	long	ADJ
gs-4426	231	31	-	-	PUNCT
gs-4426	231	32	term	term	NOUN
gs-4426	231	33	durability	durability	NOUN
gs-4426	231	34	,	,	PUNCT
gs-4426	231	35	late	late	ADV
gs-4426	231	36	-	-	PUNCT
gs-4426	231	37	emerging	emerge	VERB
gs-4426	231	38	toxicities	toxicity	NOUN
gs-4426	231	39	,	,	PUNCT
gs-4426	231	40	and	and	CCONJ
gs-4426	231	41	real	real	ADJ
gs-4426	231	42	-	-	PUNCT
gs-4426	231	43	world	world	NOUN
gs-4426	231	44	effectiveness	effectiveness	NOUN
gs-4426	231	45	across	across	ADP
gs-4426	231	46	diverse	diverse	ADJ
gs-4426	231	47	patient	patient	ADJ
gs-4426	231	48	populations	population	NOUN
gs-4426	231	49	with	with	ADP
gs-4426	231	50	varying	vary	VERB
gs-4426	231	51	disease	disease	NOUN
gs-4426	231	52	severity	severity	NOUN
gs-4426	231	53	and	and	CCONJ
gs-4426	231	54	comorbidity	comorbidity	NOUN
gs-4426	231	55	profiles	profile	NOUN
gs-4426	231	56	.	.	PUNCT
gs-4426	232	1	the	the	DET
gs-4426	232	2	expansion	expansion	NOUN
gs-4426	232	3	of	of	ADP
gs-4426	232	4	gene	gene	NOUN
gs-4426	232	5	therapy	therapy	NOUN
gs-4426	232	6	applications	application	NOUN
gs-4426	232	7	from	from	ADP
gs-4426	232	8	rare	rare	ADJ
gs-4426	232	9	monogenic	monogenic	ADJ
gs-4426	232	10	disorders	disorder	NOUN
gs-4426	232	11	to	to	ADP
gs-4426	232	12	more	more	ADV
gs-4426	232	13	prevalent	prevalent	ADJ
gs-4426	232	14	conditions	condition	NOUN
gs-4426	232	15	including	include	VERB
gs-4426	232	16	cardiovascular	cardiovascular	ADJ
gs-4426	232	17	disease	disease	NOUN
gs-4426	232	18	,	,	PUNCT
gs-4426	232	19	diabetes	diabetes	NOUN
gs-4426	232	20	,	,	PUNCT
gs-4426	232	21	and	and	CCONJ
gs-4426	232	22	autoimmune	autoimmune	ADJ
gs-4426	232	23	disorders	disorder	NOUN
gs-4426	232	24	represent	represent	VERB
gs-4426	232	25	a	a	DET
gs-4426	232	26	pivotal	pivotal	ADJ
gs-4426	232	27	evolution	evolution	NOUN
gs-4426	232	28	with	with	ADP
gs-4426	232	29	profound	profound	ADJ
gs-4426	232	30	implications	implication	NOUN
gs-4426	232	31	for	for	ADP
gs-4426	232	32	public	public	ADJ
gs-4426	232	33	health	health	NOUN
gs-4426	232	34	and	and	CCONJ
gs-4426	232	35	healthcare	healthcare	NOUN
gs-4426	232	36	economics	economic	NOUN
gs-4426	232	37	.	.	PUNCT
gs-4426	233	1	crispr	crispr	NOUN
gs-4426	233	2	-	-	PUNCT
gs-4426	233	3	based	base	VERB
gs-4426	233	4	approaches	approach	NOUN
gs-4426	233	5	targeting	target	VERB
gs-4426	233	6	pcsk9	pcsk9	NOUN
gs-4426	233	7	for	for	ADP
gs-4426	233	8	permanent	permanent	ADJ
gs-4426	233	9	cholesterol	cholesterol	NOUN
gs-4426	233	10	reduction	reduction	NOUN
gs-4426	233	11	exemplify	exemplify	VERB
gs-4426	233	12	this	this	DET
gs-4426	233	13	transition	transition	NOUN
gs-4426	233	14	,	,	PUNCT
gs-4426	233	15	potentially	potentially	ADV
gs-4426	233	16	offering	offer	VERB
gs-4426	233	17	single	single	ADJ
gs-4426	233	18	-	-	PUNCT
gs-4426	233	19	administration	administration	NOUN
gs-4426	233	20	treatment	treatment	NOUN
gs-4426	233	21	for	for	ADP
gs-4426	233	22	a	a	DET
gs-4426	233	23	modifiable	modifiable	ADJ
gs-4426	233	24	cardiovascular	cardiovascular	ADJ
gs-4426	233	25	risk	risk	NOUN
gs-4426	233	26	factor	factor	NOUN
gs-4426	233	27	affecting	affect	VERB
gs-4426	233	28	millions	million	NOUN
gs-4426	233	29	of	of	ADP
gs-4426	233	30	individuals	individual	NOUN
gs-4426	233	31	.	.	PUNCT
gs-4426	234	1	the	the	DET
gs-4426	234	2	early	early	ADJ
gs-4426	234	3	clinical	clinical	ADJ
gs-4426	234	4	data	datum	NOUN
gs-4426	234	5	demonstrated	demonstrate	VERB
gs-4426	234	6	sustained	sustained	ADJ
gs-4426	234	7	lipid	lipid	NOUN
gs-4426	234	8	reductions	reduction	NOUN
gs-4426	234	9	comparable	comparable	ADJ
gs-4426	234	10	to	to	ADP
gs-4426	234	11	daily	daily	ADJ
gs-4426	234	12	statin	statin	PROPN
gs-4426	234	13	therapy	therapy	NOUN
gs-4426	234	14	plus	plus	CCONJ
gs-4426	234	15	monthly	monthly	ADJ
gs-4426	234	16	pcsk9	pcsk9	NOUN
gs-4426	234	17	inhibitor	inhibitor	NOUN
gs-4426	234	18	injections	injection	NOUN
gs-4426	234	19	suggest	suggest	VERB
gs-4426	234	20	therapeutic	therapeutic	ADJ
gs-4426	234	21	equivalence	equivalence	NOUN
gs-4426	234	22	to	to	ADP
gs-4426	234	23	aggressive	aggressive	ADJ
gs-4426	234	24	conventional	conventional	ADJ
gs-4426	234	25	regimens	regimen	NOUN
gs-4426	234	26	while	while	SCONJ
gs-4426	234	27	eliminating	eliminate	VERB
gs-4426	234	28	adherence	adherence	NOUN
gs-4426	234	29	challenges	challenge	NOUN
gs-4426	234	30	inherent	inherent	ADJ
gs-4426	234	31	to	to	ADP
gs-4426	234	32	chronic	chronic	ADJ
gs-4426	234	33	medication	medication	NOUN
gs-4426	234	34	administration	administration	NOUN
gs-4426	234	35	.	.	PUNCT
gs-4426	235	1	however	however	ADV
gs-4426	235	2	,	,	PUNCT
gs-4426	235	3	extending	extend	VERB
gs-4426	235	4	gene	gene	NOUN
gs-4426	235	5	therapy	therapy	NOUN
gs-4426	235	6	to	to	ADP
gs-4426	235	7	common	common	ADJ
gs-4426	235	8	diseases	disease	NOUN
gs-4426	235	9	raises	raise	VERB
gs-4426	235	10	georgian	georgian	PROPN
gs-4426	235	11	scientists/	scientists/	NUM
gs-4426	235	12	.	.	PUNCT
gs-4426	236	1	7	7	NUM
gs-4426	236	2	n	n	DET
gs-4426	236	3	4	4	NUM
gs-4426	236	4	,	,	PUNCT
gs-4426	236	5	2025	2025	NUM
gs-4426	236	6	611	611	NUM
gs-4426	236	7	critical	critical	ADJ
gs-4426	236	8	questions	question	NOUN
gs-4426	236	9	regarding	regard	VERB
gs-4426	236	10	appropriate	appropriate	ADJ
gs-4426	236	11	patient	patient	ADJ
gs-4426	236	12	selection	selection	NOUN
gs-4426	236	13	,	,	PUNCT
gs-4426	236	14	risk	risk	NOUN
gs-4426	236	15	-	-	PUNCT
gs-4426	236	16	benefit	benefit	NOUN
gs-4426	236	17	considerations	consideration	NOUN
gs-4426	236	18	when	when	SCONJ
gs-4426	236	19	treating	treat	VERB
gs-4426	236	20	generally	generally	ADV
gs-4426	236	21	healthy	healthy	ADJ
gs-4426	236	22	individuals	individual	NOUN
gs-4426	236	23	for	for	ADP
gs-4426	236	24	risk	risk	NOUN
gs-4426	236	25	factor	factor	NOUN
gs-4426	236	26	modification	modification	NOUN
gs-4426	236	27	rather	rather	ADV
gs-4426	236	28	than	than	ADP
gs-4426	236	29	established	establish	VERB
gs-4426	236	30	disease	disease	NOUN
gs-4426	236	31	,	,	PUNCT
gs-4426	236	32	and	and	CCONJ
gs-4426	236	33	healthcare	healthcare	NOUN
gs-4426	236	34	system	system	NOUN
gs-4426	236	35	capacity	capacity	NOUN
gs-4426	236	36	to	to	PART
gs-4426	236	37	deliver	deliver	VERB
gs-4426	236	38	expensive	expensive	ADJ
gs-4426	236	39	single	single	ADJ
gs-4426	236	40	-	-	PUNCT
gs-4426	236	41	administration	administration	NOUN
gs-4426	236	42	therapies	therapy	NOUN
gs-4426	236	43	to	to	ADP
gs-4426	236	44	large	large	ADJ
gs-4426	236	45	populations	population	NOUN
gs-4426	236	46	.	.	PUNCT
gs-4426	237	1	the	the	DET
gs-4426	237	2	transition	transition	NOUN
gs-4426	237	3	from	from	ADP
gs-4426	237	4	treating	treat	VERB
gs-4426	237	5	severely	severely	ADV
gs-4426	237	6	ill	ill	ADJ
gs-4426	237	7	patients	patient	NOUN
gs-4426	237	8	with	with	ADP
gs-4426	237	9	life	life	NOUN
gs-4426	237	10	-	-	PUNCT
gs-4426	237	11	threatening	threaten	VERB
gs-4426	237	12	rare	rare	ADJ
gs-4426	237	13	diseases	disease	NOUN
gs-4426	237	14	to	to	ADP
gs-4426	237	15	modifying	modify	VERB
gs-4426	237	16	risk	risk	NOUN
gs-4426	237	17	factors	factor	NOUN
gs-4426	237	18	in	in	ADP
gs-4426	237	19	asymptomatic	asymptomatic	ADJ
gs-4426	237	20	individuals	individual	NOUN
gs-4426	237	21	fundamentally	fundamentally	ADV
gs-4426	237	22	changes	change	VERB
gs-4426	237	23	the	the	DET
gs-4426	237	24	ethical	ethical	ADJ
gs-4426	237	25	and	and	CCONJ
gs-4426	237	26	economic	economic	ADJ
gs-4426	237	27	calculus	calculus	NOUN
gs-4426	237	28	,	,	PUNCT
gs-4426	237	29	requiring	require	VERB
gs-4426	237	30	more	more	ADV
gs-4426	237	31	stringent	stringent	ADJ
gs-4426	237	32	safety	safety	NOUN
gs-4426	237	33	standards	standard	NOUN
gs-4426	237	34	and	and	CCONJ
gs-4426	237	35	clearer	clear	ADJ
gs-4426	237	36	evidence	evidence	NOUN
gs-4426	237	37	of	of	ADP
gs-4426	237	38	long	long	ADJ
gs-4426	237	39	-	-	PUNCT
gs-4426	237	40	term	term	NOUN
gs-4426	237	41	.	.	PUNCT
gs-4426	238	1	immunological	immunological	ADJ
gs-4426	238	2	considerations	consideration	NOUN
gs-4426	238	3	and	and	CCONJ
gs-4426	238	4	host	host	NOUN
gs-4426	238	5	responses	response	NOUN
gs-4426	238	6	immune	immune	ADJ
gs-4426	238	7	responses	response	NOUN
gs-4426	238	8	to	to	ADP
gs-4426	238	9	gene	gene	NOUN
gs-4426	238	10	therapy	therapy	NOUN
gs-4426	238	11	components	component	NOUN
gs-4426	238	12	represent	represent	VERB
gs-4426	238	13	double	double	ADV
gs-4426	238	14	-	-	PUNCT
gs-4426	238	15	edged	edge	VERB
gs-4426	238	16	phenomena	phenomenon	NOUN
gs-4426	238	17	,	,	PUNCT
gs-4426	238	18	potentially	potentially	ADV
gs-4426	238	19	limiting	limit	VERB
gs-4426	238	20	therapeutic	therapeutic	ADJ
gs-4426	238	21	efficacy	efficacy	NOUN
gs-4426	238	22	through	through	ADP
gs-4426	238	23	vector	vector	NOUN
gs-4426	238	24	neutralization	neutralization	NOUN
gs-4426	238	25	or	or	CCONJ
gs-4426	238	26	transduced	transduce	VERB
gs-4426	238	27	cell	cell	NOUN
gs-4426	238	28	clearance	clearance	NOUN
gs-4426	238	29	while	while	SCONJ
gs-4426	238	30	also	also	ADV
gs-4426	238	31	creating	create	VERB
gs-4426	238	32	safety	safety	NOUN
gs-4426	238	33	concerns	concern	NOUN
gs-4426	238	34	through	through	ADP
gs-4426	238	35	inflammatory	inflammatory	ADJ
gs-4426	238	36	toxicities	toxicity	NOUN
gs-4426	238	37	.	.	PUNCT
gs-4426	239	1	the	the	DET
gs-4426	239	2	high	high	ADJ
gs-4426	239	3	prevalence	prevalence	NOUN
gs-4426	239	4	of	of	ADP
gs-4426	239	5	pre	pre	ADJ
gs-4426	239	6	-	-	ADJ
gs-4426	239	7	existing	exist	VERB
gs-4426	239	8	neutralizing	neutralizing	ADJ
gs-4426	239	9	antibodies	antibody	NOUN
gs-4426	239	10	against	against	ADP
gs-4426	239	11	common	common	ADJ
gs-4426	239	12	aav	aav	NOUN
gs-4426	239	13	serotypes	serotype	NOUN
gs-4426	239	14	,	,	PUNCT
gs-4426	239	15	resulting	result	VERB
gs-4426	239	16	from	from	ADP
gs-4426	239	17	natural	natural	ADJ
gs-4426	239	18	viral	viral	ADJ
gs-4426	239	19	exposure	exposure	NOUN
gs-4426	239	20	throughout	throughout	ADP
gs-4426	239	21	life	life	NOUN
gs-4426	239	22	,	,	PUNCT
gs-4426	239	23	excludes	exclude	VERB
gs-4426	239	24	30	30	NUM
gs-4426	239	25	-	-	SYM
gs-4426	239	26	50	50	NUM
gs-4426	239	27	%	%	NOUN
gs-4426	239	28	of	of	ADP
gs-4426	239	29	screened	screen	VERB
gs-4426	239	30	patients	patient	NOUN
gs-4426	239	31	from	from	ADP
gs-4426	239	32	aav	aav	NOUN
gs-4426	239	33	gene	gene	NOUN
gs-4426	239	34	therapy	therapy	NOUN
gs-4426	239	35	eligibility	eligibility	NOUN
gs-4426	239	36	.	.	PUNCT
gs-4426	240	1	these	these	PRON
gs-4426	240	2	antibodies	antibodie	VERB
gs-4426	240	3	,	,	PUNCT
gs-4426	240	4	even	even	ADV
gs-4426	240	5	at	at	ADP
gs-4426	240	6	relatively	relatively	ADV
gs-4426	240	7	low	low	ADJ
gs-4426	240	8	titers	titer	NOUN
gs-4426	240	9	,	,	PUNCT
gs-4426	240	10	can	can	AUX
gs-4426	240	11	completely	completely	ADV
gs-4426	240	12	abrogate	abrogate	VERB
gs-4426	240	13	transduction	transduction	NOUN
gs-4426	240	14	efficiency	efficiency	NOUN
gs-4426	240	15	by	by	ADP
gs-4426	240	16	preventing	prevent	VERB
gs-4426	240	17	vector	vector	NOUN
gs-4426	240	18	binding	bind	VERB
gs-4426	240	19	to	to	PART
gs-4426	240	20	target	target	VERB
gs-4426	240	21	cells	cell	NOUN
gs-4426	240	22	or	or	CCONJ
gs-4426	240	23	promoting	promote	VERB
gs-4426	240	24	complement	complement	NOUN
gs-4426	240	25	-	-	PUNCT
gs-4426	240	26	mediated	mediate	VERB
gs-4426	240	27	vector	vector	NOUN
gs-4426	240	28	destruction	destruction	NOUN
gs-4426	240	29	.	.	PUNCT
gs-4426	241	1	while	while	SCONJ
gs-4426	241	2	patient	patient	ADJ
gs-4426	241	3	screening	screening	NOUN
gs-4426	241	4	enables	enable	VERB
gs-4426	241	5	identification	identification	NOUN
gs-4426	241	6	of	of	ADP
gs-4426	241	7	seronegative	seronegative	ADJ
gs-4426	241	8	individuals	individual	NOUN
gs-4426	241	9	suitable	suitable	ADJ
gs-4426	241	10	for	for	ADP
gs-4426	241	11	treatment	treatment	NOUN
gs-4426	241	12	,	,	PUNCT
gs-4426	241	13	the	the	DET
gs-4426	241	14	substantial	substantial	ADJ
gs-4426	241	15	proportion	proportion	NOUN
gs-4426	241	16	of	of	ADP
gs-4426	241	17	excluded	exclude	VERB
gs-4426	241	18	patients	patient	NOUN
gs-4426	241	19	motivated	motivate	VERB
gs-4426	241	20	investigation	investigation	NOUN
gs-4426	241	21	of	of	ADP
gs-4426	241	22	strategies	strategy	NOUN
gs-4426	241	23	to	to	PART
gs-4426	241	24	overcome	overcome	VERB
gs-4426	241	25	antibody	antibody	NOUN
gs-4426	241	26	barriers	barrier	NOUN
gs-4426	241	27	including	include	VERB
gs-4426	241	28	plasmapheresis	plasmapheresis	NOUN
gs-4426	241	29	or	or	CCONJ
gs-4426	241	30	immunoadsorption	immunoadsorption	NOUN
gs-4426	241	31	to	to	PART
gs-4426	241	32	deplete	deplete	VERB
gs-4426	241	33	circulating	circulate	VERB
gs-4426	241	34	antibodies	antibody	NOUN
gs-4426	241	35	,	,	PUNCT
gs-4426	241	36	empty	empty	ADJ
gs-4426	241	37	capsid	capsid	ADJ
gs-4426	241	38	decoys	decoy	NOUN
gs-4426	241	39	saturating	saturate	VERB
gs-4426	241	40	antibodies	antibody	NOUN
gs-4426	241	41	before	before	ADP
gs-4426	241	42	therapeutic	therapeutic	ADJ
gs-4426	241	43	vector	vector	NOUN
gs-4426	241	44	administration	administration	NOUN
gs-4426	241	45	,	,	PUNCT
gs-4426	241	46	and	and	CCONJ
gs-4426	241	47	use	use	NOUN
gs-4426	241	48	of	of	ADP
gs-4426	241	49	engineered	engineer	VERB
gs-4426	241	50	capsid	capsid	ADJ
gs-4426	241	51	variants	variant	NOUN
gs-4426	241	52	with	with	ADP
gs-4426	241	53	altered	altered	ADJ
gs-4426	241	54	antigenic	antigenic	ADJ
gs-4426	241	55	profiles	profile	NOUN
gs-4426	241	56	resistant	resistant	ADJ
gs-4426	241	57	to	to	AUX
gs-4426	241	58	neutralization	neutralization	VERB
gs-4426	241	59	by	by	ADP
gs-4426	241	60	antibodies	antibody	NOUN
gs-4426	241	61	against	against	ADP
gs-4426	241	62	natural	natural	ADJ
gs-4426	241	63	serotypes	serotype	NOUN
gs-4426	241	64	.	.	PUNCT
gs-4426	242	1	cellular	cellular	ADJ
gs-4426	242	2	immune	immune	ADJ
gs-4426	242	3	responses	response	NOUN
gs-4426	242	4	directed	direct	VERB
gs-4426	242	5	against	against	ADP
gs-4426	242	6	aav	aav	NOUN
gs-4426	242	7	capsid	capsid	NOUN
gs-4426	242	8	peptides	peptide	NOUN
gs-4426	242	9	presented	present	VERB
gs-4426	242	10	on	on	ADP
gs-4426	242	11	transduced	transduced	ADJ
gs-4426	242	12	cell	cell	NOUN
gs-4426	242	13	surfaces	surface	NOUN
gs-4426	242	14	via	via	ADP
gs-4426	242	15	mhc	mhc	PROPN
gs-4426	242	16	class	class	PROPN
gs-4426	242	17	i	i	PRON
gs-4426	242	18	molecules	molecule	NOUN
gs-4426	242	19	can	can	AUX
gs-4426	242	20	mediate	mediate	VERB
gs-4426	242	21	clearance	clearance	NOUN
gs-4426	242	22	of	of	ADP
gs-4426	242	23	transduced	transduced	ADJ
gs-4426	242	24	hepatocytes	hepatocyte	NOUN
gs-4426	242	25	and	and	CCONJ
gs-4426	242	26	loss	loss	NOUN
gs-4426	242	27	of	of	ADP
gs-4426	242	28	transgene	transgene	ADJ
gs-4426	242	29	expression	expression	NOUN
gs-4426	242	30	,	,	PUNCT
gs-4426	242	31	as	as	SCONJ
gs-4426	242	32	observed	observe	VERB
gs-4426	242	33	in	in	ADP
gs-4426	242	34	some	some	DET
gs-4426	242	35	hemophilia	hemophilia	NOUN
gs-4426	242	36	gene	gene	NOUN
gs-4426	242	37	therapy	therapy	NOUN
gs-4426	242	38	trials	trial	NOUN
gs-4426	242	39	where	where	SCONJ
gs-4426	242	40	factor	factor	NOUN
gs-4426	242	41	levels	level	NOUN
gs-4426	242	42	declined	decline	VERB
gs-4426	242	43	months	month	NOUN
gs-4426	242	44	after	after	ADP
gs-4426	242	45	achieving	achieve	VERB
gs-4426	242	46	initial	initial	ADJ
gs-4426	242	47	therapeutic	therapeutic	ADJ
gs-4426	242	48	concentrations	concentration	NOUN
gs-4426	242	49	.	.	PUNCT
gs-4426	243	1	the	the	DET
gs-4426	243	2	administration	administration	NOUN
gs-4426	243	3	of	of	ADP
gs-4426	243	4	immunosuppressive	immunosuppressive	ADJ
gs-4426	243	5	regimens	regimen	NOUN
gs-4426	243	6	including	include	VERB
gs-4426	243	7	corticosteroids	corticosteroid	NOUN
gs-4426	243	8	initiated	initiate	VERB
gs-4426	243	9	at	at	ADP
gs-4426	243	10	the	the	DET
gs-4426	243	11	time	time	NOUN
gs-4426	243	12	of	of	ADP
gs-4426	243	13	vector	vector	NOUN
gs-4426	243	14	delivery	delivery	NOUN
gs-4426	243	15	or	or	CCONJ
gs-4426	243	16	upon	upon	SCONJ
gs-4426	243	17	detection	detection	NOUN
gs-4426	243	18	of	of	ADP
gs-4426	243	19	rising	rise	VERB
gs-4426	243	20	liver	liver	NOUN
gs-4426	243	21	transaminases	transaminase	NOUN
gs-4426	243	22	indicating	indicate	VERB
gs-4426	243	23	hepatocyte	hepatocyte	ADJ
gs-4426	243	24	destruction	destruction	NOUN
gs-4426	243	25	has	have	AUX
gs-4426	243	26	proven	prove	VERB
gs-4426	243	27	effective	effective	ADJ
gs-4426	243	28	in	in	ADP
gs-4426	243	29	preserving	preserve	VERB
gs-4426	243	30	transgene	transgene	ADJ
gs-4426	243	31	expression	expression	NOUN
gs-4426	243	32	in	in	ADP
gs-4426	243	33	many	many	ADJ
gs-4426	243	34	cases	case	NOUN
gs-4426	243	35	.	.	PUNCT
gs-4426	244	1	however	however	ADV
gs-4426	244	2	,	,	PUNCT
gs-4426	244	3	immunosuppression	immunosuppression	NOUN
gs-4426	244	4	protocols	protocol	NOUN
gs-4426	244	5	add	add	VERB
gs-4426	244	6	complexity	complexity	NOUN
gs-4426	244	7	,	,	PUNCT
gs-4426	244	8	potential	potential	ADJ
gs-4426	244	9	toxicity	toxicity	NOUN
gs-4426	244	10	,	,	PUNCT
gs-4426	244	11	and	and	CCONJ
gs-4426	244	12	infection	infection	NOUN
gs-4426	244	13	risks	risk	NOUN
gs-4426	244	14	,	,	PUNCT
gs-4426	244	15	while	while	SCONJ
gs-4426	244	16	their	their	PRON
gs-4426	244	17	optimal	optimal	ADJ
gs-4426	244	18	intensity	intensity	NOUN
gs-4426	244	19	and	and	CCONJ
gs-4426	244	20	duration	duration	NOUN
gs-4426	244	21	remain	remain	VERB
gs-4426	244	22	incompletely	incompletely	ADV
gs-4426	244	23	defined	define	VERB
gs-4426	244	24	.	.	PUNCT
gs-4426	245	1	the	the	DET
gs-4426	245	2	development	development	NOUN
gs-4426	245	3	of	of	ADP
gs-4426	245	4	tolerogenic	tolerogenic	ADJ
gs-4426	245	5	vectors	vector	NOUN
gs-4426	245	6	incorporating	incorporate	VERB
gs-4426	245	7	immunomodulatory	immunomodulatory	ADJ
gs-4426	245	8	transgenes	transgene	NOUN
gs-4426	245	9	or	or	CCONJ
gs-4426	245	10	capsid	capsid	NOUN
gs-4426	245	11	modifications	modification	NOUN
gs-4426	245	12	reducing	reduce	VERB
gs-4426	245	13	antigen	antigen	ADJ
gs-4426	245	14	presentation	presentation	NOUN
gs-4426	245	15	represents	represent	VERB
gs-4426	245	16	an	an	DET
gs-4426	245	17	alternative	alternative	ADJ
gs-4426	245	18	approach	approach	NOUN
gs-4426	245	19	potentially	potentially	ADV
gs-4426	245	20	eliminating	eliminate	VERB
gs-4426	245	21	immunosuppression	immunosuppression	NOUN
gs-4426	245	22	requirements	requirement	NOUN
gs-4426	245	23	.	.	PUNCT
gs-4426	246	1	immune	immune	ADJ
gs-4426	246	2	responses	response	NOUN
gs-4426	246	3	to	to	ADP
gs-4426	246	4	transgene	transgene	ADJ
gs-4426	246	5	products	product	NOUN
gs-4426	246	6	constitute	constitute	VERB
gs-4426	246	7	another	another	DET
gs-4426	246	8	critical	critical	ADJ
gs-4426	246	9	consideration	consideration	NOUN
gs-4426	246	10	,	,	PUNCT
gs-4426	246	11	particularly	particularly	ADV
gs-4426	246	12	in	in	ADP
gs-4426	246	13	patients	patient	NOUN
gs-4426	246	14	with	with	ADP
gs-4426	246	15	severe	severe	ADJ
gs-4426	246	16	loss	loss	NOUN
gs-4426	246	17	-	-	PUNCT
gs-4426	246	18	of	of	ADP
gs-4426	246	19	-	-	PUNCT
gs-4426	246	20	function	function	NOUN
gs-4426	246	21	mutations	mutation	NOUN
gs-4426	246	22	resulting	result	VERB
gs-4426	246	23	in	in	ADP
gs-4426	246	24	complete	complete	ADJ
gs-4426	246	25	absence	absence	NOUN
gs-4426	246	26	of	of	ADP
gs-4426	246	27	the	the	DET
gs-4426	246	28	native	native	ADJ
gs-4426	246	29	protein	protein	NOUN
gs-4426	246	30	.	.	PUNCT
gs-4426	247	1	such	such	ADJ
gs-4426	247	2	patients	patient	NOUN
gs-4426	247	3	have	have	AUX
gs-4426	247	4	not	not	PART
gs-4426	247	5	developed	develop	VERB
gs-4426	247	6	immune	immune	ADJ
gs-4426	247	7	tolerance	tolerance	NOUN
gs-4426	247	8	to	to	ADP
gs-4426	247	9	the	the	DET
gs-4426	247	10	protein	protein	NOUN
gs-4426	247	11	during	during	ADP
gs-4426	247	12	development	development	NOUN
gs-4426	247	13	and	and	CCONJ
gs-4426	247	14	may	may	AUX
gs-4426	247	15	recognize	recognize	VERB
gs-4426	247	16	gene	gene	NOUN
gs-4426	247	17	therapy	therapy	NOUN
gs-4426	247	18	-	-	PUNCT
gs-4426	247	19	produced	produce	VERB
gs-4426	247	20	protein	protein	NOUN
gs-4426	247	21	as	as	ADP
gs-4426	247	22	foreign	foreign	ADJ
gs-4426	247	23	,	,	PUNCT
gs-4426	247	24	mounting	mount	VERB
gs-4426	247	25	neutralizing	neutralize	VERB
gs-4426	247	26	antibody	antibody	NOUN
gs-4426	247	27	responses	response	NOUN
gs-4426	247	28	that	that	PRON
gs-4426	247	29	eliminate	eliminate	VERB
gs-4426	247	30	therapeutic	therapeutic	ADJ
gs-4426	247	31	benefit	benefit	NOUN
gs-4426	247	32	.	.	PUNCT
gs-4426	248	1	this	this	DET
gs-4426	248	2	phenomenon	phenomenon	NOUN
gs-4426	248	3	has	have	AUX
gs-4426	248	4	been	be	AUX
gs-4426	248	5	observed	observe	VERB
gs-4426	248	6	in	in	ADP
gs-4426	248	7	some	some	DET
gs-4426	248	8	duchenne	duchenne	NOUN
gs-4426	248	9	muscular	muscular	ADJ
gs-4426	248	10	dystrophy	dystrophy	NOUN
gs-4426	248	11	gene	gene	NOUN
gs-4426	248	12	therapy	therapy	NOUN
gs-4426	248	13	trials	trial	NOUN
gs-4426	248	14	where	where	SCONJ
gs-4426	248	15	patients	patient	NOUN
gs-4426	248	16	with	with	ADP
gs-4426	248	17	deletion	deletion	NOUN
gs-4426	248	18	mutations	mutation	NOUN
gs-4426	248	19	expected	expect	VERB
gs-4426	248	20	to	to	PART
gs-4426	248	21	produce	produce	VERB
gs-4426	248	22	no	no	DET
gs-4426	248	23	dystrophin	dystrophin	ADJ
gs-4426	248	24	protein	protein	NOUN
gs-4426	248	25	developed	develop	VERB
gs-4426	248	26	antibodies	antibody	NOUN
gs-4426	248	27	against	against	ADP
gs-4426	248	28	the	the	DET
gs-4426	248	29	mini	mini	ADJ
gs-4426	248	30	-	-	ADJ
gs-4426	248	31	dystrophin	dystrophin	ADJ
gs-4426	248	32	transgene	transgene	NOUN
gs-4426	248	33	product	product	NOUN
gs-4426	248	34	,	,	PUNCT
gs-4426	248	35	limiting	limit	VERB
gs-4426	248	36	efficacy	efficacy	NOUN
gs-4426	248	37	.	.	PUNCT
gs-4426	249	1	strategies	strategy	NOUN
gs-4426	249	2	addressing	address	VERB
gs-4426	249	3	this	this	DET
gs-4426	249	4	challenge	challenge	NOUN
gs-4426	249	5	include	include	VERB
gs-4426	249	6	selection	selection	NOUN
gs-4426	249	7	of	of	ADP
gs-4426	249	8	minimally	minimally	ADV
gs-4426	249	9	immunogenic	immunogenic	ADJ
gs-4426	249	10	transgene	transgene	NOUN
gs-4426	249	11	designs	design	NOUN
gs-4426	249	12	,	,	PUNCT
gs-4426	249	13	incorporation	incorporation	NOUN
gs-4426	249	14	of	of	ADP
gs-4426	249	15	immune	immune	ADJ
gs-4426	249	16	tolerance	tolerance	NOUN
gs-4426	249	17	induction	induction	NOUN
gs-4426	249	18	protocols	protocol	NOUN
gs-4426	249	19	,	,	PUNCT
gs-4426	249	20	and	and	CCONJ
gs-4426	249	21	genetic	genetic	ADJ
gs-4426	249	22	modification	modification	NOUN
gs-4426	249	23	to	to	PART
gs-4426	249	24	match	match	VERB
gs-4426	249	25	transgene	transgene	ADJ
gs-4426	249	26	products	product	NOUN
gs-4426	249	27	more	more	ADV
gs-4426	249	28	closely	closely	ADV
gs-4426	249	29	to	to	PART
gs-4426	249	30	patient	patient	VERB
gs-4426	249	31	genetic	genetic	ADJ
gs-4426	249	32	backgrounds	background	NOUN
gs-4426	249	33	.	.	PUNCT
gs-4426	250	1	the	the	DET
gs-4426	250	2	development	development	NOUN
gs-4426	250	3	of	of	ADP
gs-4426	250	4	predictive	predictive	ADJ
gs-4426	250	5	georgian	georgian	NOUN
gs-4426	250	6	scientists/	scientists/	NUM
gs-4426	250	7	.	.	PUNCT
gs-4426	251	1	7	7	NUM
gs-4426	251	2	n	n	DET
gs-4426	251	3	4	4	NUM
gs-4426	251	4	,	,	PUNCT
gs-4426	251	5	2025	2025	NUM
gs-4426	251	6	612	612	NUM
gs-4426	251	7	biomarkers	biomarker	NOUN
gs-4426	251	8	identifying	identify	VERB
gs-4426	251	9	patients	patient	NOUN
gs-4426	251	10	at	at	ADP
gs-4426	251	11	high	high	ADJ
gs-4426	251	12	risk	risk	NOUN
gs-4426	251	13	for	for	ADP
gs-4426	251	14	anti	anti	ADJ
gs-4426	251	15	-	-	ADJ
gs-4426	251	16	transgene	transgene	ADJ
gs-4426	251	17	immune	immune	ADJ
gs-4426	251	18	responses	response	NOUN
gs-4426	251	19	would	would	AUX
gs-4426	251	20	enable	enable	VERB
gs-4426	251	21	proactive	proactive	ADJ
gs-4426	251	22	intervention	intervention	NOUN
gs-4426	251	23	before	before	SCONJ
gs-4426	251	24	antibodies	antibody	NOUN
gs-4426	251	25	develop	develop	VERB
gs-4426	251	26	.	.	PUNCT
gs-4426	252	1	car	car	NOUN
gs-4426	252	2	-	-	PUNCT
gs-4426	252	3	t	t	NOUN
gs-4426	252	4	cell	cell	NOUN
gs-4426	252	5	therapy	therapy	NOUN
gs-4426	252	6	toxicities	toxicity	NOUN
gs-4426	252	7	including	include	VERB
gs-4426	252	8	cytokine	cytokine	ADJ
gs-4426	252	9	release	release	NOUN
gs-4426	252	10	syndrome	syndrome	NOUN
gs-4426	252	11	and	and	CCONJ
gs-4426	252	12	immune	immune	ADJ
gs-4426	252	13	effector	effector	NOUN
gs-4426	252	14	cellassociated	cellassociate	VERB
gs-4426	252	15	neurotoxicity	neurotoxicity	NOUN
gs-4426	252	16	syndrome	syndrome	NOUN
gs-4426	252	17	represent	represent	VERB
gs-4426	252	18	acute	acute	ADJ
gs-4426	252	19	inflammatory	inflammatory	ADJ
gs-4426	252	20	complications	complication	NOUN
gs-4426	252	21	requiring	require	VERB
gs-4426	252	22	specialized	specialized	ADJ
gs-4426	252	23	management	management	NOUN
gs-4426	252	24	expertise	expertise	NOUN
gs-4426	252	25	.	.	PUNCT
gs-4426	253	1	cytokine	cytokine	ADJ
gs-4426	253	2	release	release	NOUN
gs-4426	253	3	syndrome	syndrome	NOUN
gs-4426	253	4	results	result	NOUN
gs-4426	253	5	from	from	ADP
gs-4426	253	6	massive	massive	ADJ
gs-4426	253	7	car	car	NOUN
gs-4426	253	8	-	-	PUNCT
gs-4426	253	9	t	t	NOUN
gs-4426	253	10	cell	cell	NOUN
gs-4426	253	11	activation	activation	NOUN
gs-4426	253	12	and	and	CCONJ
gs-4426	253	13	expansion	expansion	NOUN
gs-4426	253	14	triggering	trigger	VERB
gs-4426	253	15	systemic	systemic	ADJ
gs-4426	253	16	release	release	NOUN
gs-4426	253	17	of	of	ADP
gs-4426	253	18	pro	pro	ADJ
gs-4426	253	19	-	-	ADJ
gs-4426	253	20	inflammatory	inflammatory	ADJ
gs-4426	253	21	cytokines	cytokine	NOUN
gs-4426	253	22	including	include	VERB
gs-4426	253	23	il-6	il-6	NUM
gs-4426	253	24	,	,	PUNCT
gs-4426	253	25	il-1	il-1	ADP
gs-4426	253	26	,	,	PUNCT
gs-4426	253	27	and	and	CCONJ
gs-4426	253	28	interferon	interferon	ADJ
gs-4426	253	29	-	-	PUNCT
gs-4426	253	30	gamma	gamma	NOUN
gs-4426	253	31	,	,	PUNCT
gs-4426	253	32	manifesting	manifest	VERB
gs-4426	253	33	as	as	ADP
gs-4426	253	34	fever	fever	NOUN
gs-4426	253	35	,	,	PUNCT
gs-4426	253	36	hypotension	hypotension	NOUN
gs-4426	253	37	,	,	PUNCT
gs-4426	253	38	hypoxia	hypoxia	NOUN
gs-4426	253	39	,	,	PUNCT
gs-4426	253	40	and	and	CCONJ
gs-4426	253	41	in	in	ADP
gs-4426	253	42	severe	severe	ADJ
gs-4426	253	43	cases	case	NOUN
gs-4426	253	44	multiorgan	multiorgan	VERB
gs-4426	253	45	dysfunction	dysfunction	NOUN
gs-4426	253	46	.	.	PUNCT
gs-4426	254	1	the	the	DET
gs-4426	254	2	identification	identification	NOUN
gs-4426	254	3	of	of	ADP
gs-4426	254	4	il-6	il-6	NOUN
gs-4426	254	5	as	as	ADP
gs-4426	254	6	a	a	DET
gs-4426	254	7	key	key	ADJ
gs-4426	254	8	mediator	mediator	NOUN
gs-4426	254	9	and	and	CCONJ
gs-4426	254	10	demonstration	demonstration	NOUN
gs-4426	254	11	that	that	DET
gs-4426	254	12	tocilizumab	tocilizumab	NOUN
gs-4426	254	13	,	,	PUNCT
gs-4426	254	14	an	an	DET
gs-4426	254	15	il-6	il-6	NOUN
gs-4426	254	16	receptor	receptor	NOUN
gs-4426	254	17	antagonist	antagonist	NOUN
gs-4426	254	18	,	,	PUNCT
gs-4426	254	19	effectively	effectively	ADV
gs-4426	254	20	mitigates	mitigate	VERB
gs-4426	254	21	severe	severe	ADJ
gs-4426	254	22	cases	case	NOUN
gs-4426	254	23	has	have	AUX
gs-4426	254	24	substantially	substantially	ADV
gs-4426	254	25	improved	improve	VERB
gs-4426	254	26	safety	safety	NOUN
gs-4426	254	27	profiles	profile	NOUN
gs-4426	254	28	and	and	CCONJ
gs-4426	254	29	enabled	enable	VERB
gs-4426	254	30	outpatient	outpatient	NOUN
gs-4426	254	31	car	car	NOUN
gs-4426	254	32	-	-	PUNCT
gs-4426	254	33	t	t	NOUN
gs-4426	254	34	administration	administration	NOUN
gs-4426	254	35	in	in	ADP
gs-4426	254	36	selected	select	VERB
gs-4426	254	37	low	low	ADJ
gs-4426	254	38	-	-	PUNCT
gs-4426	254	39	risk	risk	NOUN
gs-4426	254	40	patients	patient	NOUN
gs-4426	254	41	.	.	PUNCT
gs-4426	255	1	however	however	ADV
gs-4426	255	2	,	,	PUNCT
gs-4426	255	3	cytokine	cytokine	ADJ
gs-4426	255	4	release	release	NOUN
gs-4426	255	5	syndrome	syndrome	NOUN
gs-4426	255	6	remains	remain	VERB
gs-4426	255	7	unpredictable	unpredictable	ADJ
gs-4426	255	8	,	,	PUNCT
gs-4426	255	9	with	with	ADP
gs-4426	255	10	severity	severity	NOUN
gs-4426	255	11	not	not	PART
gs-4426	255	12	consistently	consistently	ADV
gs-4426	255	13	correlating	correlate	VERB
gs-4426	255	14	with	with	ADP
gs-4426	255	15	tumor	tumor	NOUN
gs-4426	255	16	burden	burden	NOUN
gs-4426	255	17	or	or	CCONJ
gs-4426	255	18	other	other	ADJ
gs-4426	255	19	pre	pre	ADJ
gs-4426	255	20	-	-	ADJ
gs-4426	255	21	treatment	treatment	ADJ
gs-4426	255	22	characteristics	characteristic	NOUN
gs-4426	255	23	,	,	PUNCT
gs-4426	255	24	necessitating	necessitate	VERB
gs-4426	255	25	close	close	ADJ
gs-4426	255	26	monitoring	monitoring	NOUN
gs-4426	255	27	and	and	CCONJ
gs-4426	255	28	immediate	immediate	ADJ
gs-4426	255	29	intervention	intervention	NOUN
gs-4426	255	30	capability	capability	NOUN
gs-4426	255	31	.	.	PUNCT
gs-4426	256	1	neurotoxicity	neurotoxicity	NOUN
gs-4426	256	2	mechanisms	mechanism	NOUN
gs-4426	256	3	remain	remain	AUX
gs-4426	256	4	incompletely	incompletely	ADV
gs-4426	256	5	understood	understand	VERB
gs-4426	256	6	but	but	CCONJ
gs-4426	256	7	appear	appear	VERB
gs-4426	256	8	to	to	PART
gs-4426	256	9	involve	involve	VERB
gs-4426	256	10	cytokine	cytokine	NOUN
gs-4426	256	11	-	-	PUNCT
gs-4426	256	12	mediated	mediate	VERB
gs-4426	256	13	blood	blood	NOUN
gs-4426	256	14	-	-	PUNCT
gs-4426	256	15	brain	brain	NOUN
gs-4426	256	16	barrier	barrier	NOUN
gs-4426	256	17	disruption	disruption	NOUN
gs-4426	256	18	and	and	CCONJ
gs-4426	256	19	direct	direct	ADJ
gs-4426	256	20	effects	effect	NOUN
gs-4426	256	21	on	on	ADP
gs-4426	256	22	cerebral	cerebral	ADJ
gs-4426	256	23	endothelium	endothelium	NOUN
gs-4426	256	24	,	,	PUNCT
gs-4426	256	25	motivating	motivating	NOUN
gs-4426	256	26	investigation	investigation	NOUN
gs-4426	256	27	of	of	ADP
gs-4426	256	28	prophylactic	prophylactic	ADJ
gs-4426	256	29	strategies	strategy	NOUN
gs-4426	256	30	and	and	CCONJ
gs-4426	256	31	novel	novel	ADJ
gs-4426	256	32	therapeutic	therapeutic	ADJ
gs-4426	256	33	interventions	intervention	NOUN
gs-4426	256	34	.	.	PUNCT
gs-4426	257	1	economic	economic	ADJ
gs-4426	257	2	sustainability	sustainability	NOUN
gs-4426	257	3	and	and	CCONJ
gs-4426	257	4	access	access	NOUN
gs-4426	257	5	challenges	challenge	VERB
gs-4426	257	6	the	the	DET
gs-4426	257	7	economic	economic	ADJ
gs-4426	257	8	landscape	landscape	NOUN
gs-4426	257	9	of	of	ADP
gs-4426	257	10	gene	gene	NOUN
gs-4426	257	11	therapy	therapy	NOUN
gs-4426	257	12	represents	represent	VERB
gs-4426	257	13	perhaps	perhaps	ADV
gs-4426	257	14	the	the	DET
gs-4426	257	15	most	most	ADV
gs-4426	257	16	contentious	contentious	ADJ
gs-4426	257	17	aspect	aspect	NOUN
gs-4426	257	18	of	of	ADP
gs-4426	257	19	the	the	DET
gs-4426	257	20	field	field	NOUN
gs-4426	257	21	,	,	PUNCT
gs-4426	257	22	with	with	ADP
gs-4426	257	23	tension	tension	NOUN
gs-4426	257	24	between	between	ADP
gs-4426	257	25	recognizing	recognize	VERB
gs-4426	257	26	transformative	transformative	ADJ
gs-4426	257	27	clinical	clinical	ADJ
gs-4426	257	28	value	value	NOUN
gs-4426	257	29	and	and	CCONJ
gs-4426	257	30	confronting	confront	VERB
gs-4426	257	31	unprecedented	unprecedented	ADJ
gs-4426	257	32	pricing	pricing	NOUN
gs-4426	257	33	that	that	PRON
gs-4426	257	34	challenges	challenge	VERB
gs-4426	257	35	healthcare	healthcare	NOUN
gs-4426	257	36	system	system	NOUN
gs-4426	257	37	sustainability	sustainability	NOUN
gs-4426	257	38	.	.	PUNCT
gs-4426	258	1	approved	approve	VERB
gs-4426	258	2	gene	gene	NOUN
gs-4426	258	3	therapies	therapy	NOUN
gs-4426	258	4	range	range	VERB
gs-4426	258	5	from	from	ADP
gs-4426	258	6	$	$	SYM
gs-4426	258	7	400,000	400,000	NUM
gs-4426	258	8	for	for	ADP
gs-4426	258	9	some	some	DET
gs-4426	258	10	car	car	NOUN
gs-4426	258	11	-	-	PUNCT
gs-4426	258	12	t	t	NOUN
gs-4426	258	13	products	product	NOUN
gs-4426	258	14	to	to	ADP
gs-4426	258	15	$	$	SYM
gs-4426	258	16	4.25	4.25	NUM
gs-4426	258	17	million	million	NUM
gs-4426	258	18	for	for	ADP
gs-4426	258	19	zolgensma	zolgensma	NOUN
gs-4426	258	20	,	,	PUNCT
gs-4426	258	21	with	with	ADP
gs-4426	258	22	most	most	ADJ
gs-4426	258	23	products	product	NOUN
gs-4426	258	24	priced	price	VERB
gs-4426	258	25	above	above	ADP
gs-4426	258	26	$	$	SYM
gs-4426	258	27	1	1	NUM
gs-4426	258	28	million	million	NUM
gs-4426	258	29	per	per	ADP
gs-4426	258	30	treatment	treatment	NOUN
gs-4426	258	31	.	.	PUNCT
gs-4426	259	1	manufacturers	manufacturer	NOUN
gs-4426	259	2	justify	justify	VERB
gs-4426	259	3	these	these	DET
gs-4426	259	4	prices	price	NOUN
gs-4426	259	5	through	through	ADP
gs-4426	259	6	multiple	multiple	ADJ
gs-4426	259	7	arguments	argument	NOUN
gs-4426	259	8	:	:	PUNCT
gs-4426	259	9	substantial	substantial	ADJ
gs-4426	259	10	development	development	NOUN
gs-4426	259	11	costs	cost	NOUN
gs-4426	259	12	including	include	VERB
gs-4426	259	13	failed	fail	VERB
gs-4426	259	14	programs	program	NOUN
gs-4426	259	15	subsidized	subsidize	VERB
gs-4426	259	16	by	by	ADP
gs-4426	259	17	successful	successful	ADJ
gs-4426	259	18	products	product	NOUN
gs-4426	259	19	,	,	PUNCT
gs-4426	259	20	complex	complex	ADJ
gs-4426	259	21	and	and	CCONJ
gs-4426	259	22	expensive	expensive	ADJ
gs-4426	259	23	manufacturing	manufacturing	NOUN
gs-4426	259	24	processes	process	NOUN
gs-4426	259	25	,	,	PUNCT
gs-4426	259	26	small	small	ADJ
gs-4426	259	27	patient	patient	ADJ
gs-4426	259	28	populations	population	NOUN
gs-4426	259	29	for	for	ADP
gs-4426	259	30	rare	rare	ADJ
gs-4426	259	31	disease	disease	NOUN
gs-4426	259	32	indications	indication	NOUN
gs-4426	259	33	limiting	limit	VERB
gs-4426	259	34	total	total	ADJ
gs-4426	259	35	revenue	revenue	NOUN
gs-4426	259	36	potential	potential	NOUN
gs-4426	259	37	,	,	PUNCT
gs-4426	259	38	and	and	CCONJ
gs-4426	259	39	most	most	ADV
gs-4426	259	40	prominently	prominently	ADV
gs-4426	259	41	,	,	PUNCT
gs-4426	259	42	the	the	DET
gs-4426	259	43	assertion	assertion	NOUN
gs-4426	259	44	that	that	SCONJ
gs-4426	259	45	single	single	ADJ
gs-4426	259	46	-	-	PUNCT
gs-4426	259	47	administration	administration	NOUN
gs-4426	259	48	curative	curative	ADJ
gs-4426	259	49	therapies	therapy	NOUN
gs-4426	259	50	delivering	deliver	VERB
gs-4426	259	51	lifetime	lifetime	NOUN
gs-4426	259	52	benefit	benefit	NOUN
gs-4426	259	53	represent	represent	VERB
gs-4426	259	54	good	good	ADJ
gs-4426	259	55	value	value	NOUN
gs-4426	259	56	compared	compare	VERB
gs-4426	259	57	to	to	ADP
gs-4426	259	58	chronic	chronic	ADJ
gs-4426	259	59	conventional	conventional	ADJ
gs-4426	259	60	treatments	treatment	NOUN
gs-4426	259	61	costing	cost	VERB
gs-4426	259	62	hundreds	hundred	NOUN
gs-4426	259	63	of	of	ADP
gs-4426	259	64	thousands	thousand	NOUN
gs-4426	259	65	or	or	CCONJ
gs-4426	259	66	millions	million	NOUN
gs-4426	259	67	of	of	ADP
gs-4426	259	68	dollars	dollar	NOUN
gs-4426	259	69	over	over	ADP
gs-4426	259	70	patient	patient	NOUN
gs-4426	259	71	lifetimes	lifetime	NOUN
gs-4426	259	72	.	.	PUNCT
gs-4426	260	1	health	health	NOUN
gs-4426	260	2	economic	economic	ADJ
gs-4426	260	3	analyses	analysis	NOUN
gs-4426	260	4	from	from	ADP
gs-4426	260	5	manufacturer	manufacturer	NOUN
gs-4426	260	6	-	-	PUNCT
gs-4426	260	7	sponsored	sponsor	VERB
gs-4426	260	8	studies	study	NOUN
gs-4426	260	9	typically	typically	ADV
gs-4426	260	10	support	support	VERB
gs-4426	260	11	cost	cost	NOUN
gs-4426	260	12	-	-	PUNCT
gs-4426	260	13	effectiveness	effectiveness	NOUN
gs-4426	260	14	at	at	ADP
gs-4426	260	15	current	current	ADJ
gs-4426	260	16	pricing	pricing	NOUN
gs-4426	260	17	when	when	SCONJ
gs-4426	260	18	assessed	assess	VERB
gs-4426	260	19	using	use	VERB
gs-4426	260	20	standard	standard	ADJ
gs-4426	260	21	quality	quality	NOUN
gs-4426	260	22	-	-	PUNCT
gs-4426	260	23	adjusted	adjust	VERB
gs-4426	260	24	life	life	NOUN
gs-4426	260	25	year	year	NOUN
gs-4426	260	26	frameworks	framework	NOUN
gs-4426	260	27	and	and	CCONJ
gs-4426	260	28	time	time	NOUN
gs-4426	260	29	horizons	horizon	NOUN
gs-4426	260	30	spanning	span	VERB
gs-4426	260	31	patient	patient	ADJ
gs-4426	260	32	lifetimes	lifetime	NOUN
gs-4426	260	33	.	.	PUNCT
gs-4426	261	1	however	however	ADV
gs-4426	261	2	,	,	PUNCT
gs-4426	261	3	these	these	DET
gs-4426	261	4	economic	economic	ADJ
gs-4426	261	5	arguments	argument	NOUN
gs-4426	261	6	face	face	VERB
gs-4426	261	7	substantial	substantial	ADJ
gs-4426	261	8	scrutiny	scrutiny	NOUN
gs-4426	261	9	from	from	ADP
gs-4426	261	10	payers	payer	NOUN
gs-4426	261	11	,	,	PUNCT
gs-4426	261	12	health	health	NOUN
gs-4426	261	13	policy	policy	NOUN
gs-4426	261	14	experts	expert	NOUN
gs-4426	261	15	,	,	PUNCT
gs-4426	261	16	and	and	CCONJ
gs-4426	261	17	patient	patient	ADJ
gs-4426	261	18	advocates	advocate	NOUN
gs-4426	261	19	who	who	PRON
gs-4426	261	20	question	question	VERB
gs-4426	261	21	whether	whether	SCONJ
gs-4426	261	22	current	current	ADJ
gs-4426	261	23	pricing	pricing	NOUN
gs-4426	261	24	reflects	reflect	VERB
gs-4426	261	25	genuine	genuine	ADJ
gs-4426	261	26	value	value	NOUN
gs-4426	261	27	or	or	CCONJ
gs-4426	261	28	exploits	exploit	VERB
gs-4426	261	29	monopoly	monopoly	NOUN
gs-4426	261	30	positions	position	NOUN
gs-4426	261	31	for	for	ADP
gs-4426	261	32	rare	rare	ADJ
gs-4426	261	33	disease	disease	NOUN
gs-4426	261	34	treatments	treatment	NOUN
gs-4426	261	35	lacking	lack	VERB
gs-4426	261	36	alternatives	alternative	NOUN
gs-4426	261	37	.	.	PUNCT
gs-4426	262	1	the	the	DET
gs-4426	262	2	concentration	concentration	NOUN
gs-4426	262	3	of	of	ADP
gs-4426	262	4	costs	cost	NOUN
gs-4426	262	5	in	in	ADP
gs-4426	262	6	a	a	DET
gs-4426	262	7	single	single	ADJ
gs-4426	262	8	budget	budget	NOUN
gs-4426	262	9	year	year	NOUN
gs-4426	262	10	creates	create	VERB
gs-4426	262	11	significant	significant	ADJ
gs-4426	262	12	financial	financial	ADJ
gs-4426	262	13	impact	impact	NOUN
gs-4426	262	14	even	even	ADV
gs-4426	262	15	for	for	ADP
gs-4426	262	16	diseases	disease	NOUN
gs-4426	262	17	with	with	ADP
gs-4426	262	18	small	small	ADJ
gs-4426	262	19	patient	patient	ADJ
gs-4426	262	20	populations	population	NOUN
gs-4426	262	21	,	,	PUNCT
gs-4426	262	22	potentially	potentially	ADV
gs-4426	262	23	crowding	crowd	VERB
gs-4426	262	24	out	out	ADP
gs-4426	262	25	other	other	ADJ
gs-4426	262	26	healthcare	healthcare	NOUN
gs-4426	262	27	services	service	NOUN
gs-4426	262	28	or	or	CCONJ
gs-4426	262	29	necessitating	necessitate	VERB
gs-4426	262	30	budget	budget	NOUN
gs-4426	262	31	increases	increase	NOUN
gs-4426	262	32	that	that	PRON
gs-4426	262	33	payers	payer	NOUN
gs-4426	262	34	resist	resist	VERB
gs-4426	262	35	.	.	PUNCT
gs-4426	263	1	the	the	DET
gs-4426	263	2	institute	institute	NOUN
gs-4426	263	3	for	for	ADP
gs-4426	263	4	clinical	clinical	ADJ
gs-4426	263	5	and	and	CCONJ
gs-4426	263	6	economic	economic	ADJ
gs-4426	263	7	article	article	NOUN
gs-4426	263	8	,	,	PUNCT
gs-4426	263	9	an	an	DET
gs-4426	263	10	independent	independent	ADJ
gs-4426	263	11	health	health	NOUN
gs-4426	263	12	economic	economic	ADJ
gs-4426	263	13	assessment	assessment	NOUN
gs-4426	263	14	organization	organization	NOUN
gs-4426	263	15	,	,	PUNCT
gs-4426	263	16	has	have	AUX
gs-4426	263	17	evaluated	evaluate	VERB
gs-4426	263	18	several	several	ADJ
gs-4426	263	19	gene	gene	NOUN
gs-4426	263	20	therapies	therapy	NOUN
gs-4426	263	21	and	and	CCONJ
gs-4426	263	22	generally	generally	ADV
gs-4426	263	23	concluded	conclude	VERB
gs-4426	263	24	that	that	SCONJ
gs-4426	263	25	prices	price	NOUN
gs-4426	263	26	exceeding	exceed	VERB
gs-4426	263	27	$	$	SYM
gs-4426	263	28	1	1	NUM
gs-4426	263	29	-	-	SYM
gs-4426	263	30	2	2	NUM
gs-4426	263	31	million	million	NUM
gs-4426	263	32	per	per	ADP
gs-4426	263	33	treatment	treatment	NOUN
gs-4426	263	34	are	be	AUX
gs-4426	263	35	not	not	PART
gs-4426	263	36	cost	cost	NOUN
gs-4426	263	37	-	-	PUNCT
gs-4426	263	38	effective	effective	ADJ
gs-4426	263	39	at	at	ADP
gs-4426	263	40	conventional	conventional	ADJ
gs-4426	263	41	willingness	willingness	NOUN
gs-4426	263	42	-	-	PUNCT
gs-4426	263	43	to	to	ADP
gs-4426	263	44	-	-	PUNCT
gs-4426	263	45	pay	pay	NOUN
gs-4426	263	46	thresholds	threshold	NOUN
gs-4426	263	47	,	,	PUNCT
gs-4426	263	48	recommending	recommend	VERB
gs-4426	263	49	substantial	substantial	ADJ
gs-4426	263	50	price	price	NOUN
gs-4426	263	51	reductions	reduction	NOUN
gs-4426	263	52	.	.	PUNCT
gs-4426	264	1	the	the	DET
gs-4426	264	2	limited	limited	ADJ
gs-4426	264	3	transparency	transparency	NOUN
gs-4426	264	4	regarding	regard	VERB
gs-4426	264	5	manufacturing	manufacturing	NOUN
gs-4426	264	6	costs	cost	NOUN
gs-4426	264	7	and	and	CCONJ
gs-4426	264	8	profit	profit	NOUN
gs-4426	264	9	margins	margin	NOUN
gs-4426	264	10	complicates	complicate	VERB
gs-4426	264	11	assessment	assessment	NOUN
gs-4426	264	12	of	of	ADP
gs-4426	264	13	whether	whether	SCONJ
gs-4426	264	14	current	current	ADJ
gs-4426	264	15	pricing	pricing	NOUN
gs-4426	264	16	reflects	reflect	VERB
gs-4426	264	17	genuine	genuine	ADJ
gs-4426	264	18	economic	economic	ADJ
gs-4426	264	19	necessity	necessity	NOUN
gs-4426	264	20	or	or	CCONJ
gs-4426	264	21	represents	represent	VERB
gs-4426	264	22	profit	profit	NOUN
gs-4426	264	23	maximization	maximization	NOUN
gs-4426	264	24	strategies	strategy	NOUN
gs-4426	264	25	common	common	ADJ
gs-4426	264	26	in	in	ADP
gs-4426	264	27	pharmaceutical	pharmaceutical	ADJ
gs-4426	264	28	markets	market	NOUN
gs-4426	264	29	with	with	ADP
gs-4426	264	30	limited	limited	ADJ
gs-4426	264	31	competition	competition	NOUN
gs-4426	264	32	and	and	CCONJ
gs-4426	264	33	inelastic	inelastic	ADJ
gs-4426	264	34	demand	demand	NOUN
gs-4426	264	35	.	.	PUNCT
gs-4426	265	1	georgian	georgian	NOUN
gs-4426	265	2	scientists/	scientists/	NUM
gs-4426	265	3	.	.	PUNCT
gs-4426	266	1	7	7	NUM
gs-4426	266	2	n	n	DET
gs-4426	266	3	4	4	NUM
gs-4426	266	4	,	,	PUNCT
gs-4426	266	5	2025	2025	NUM
gs-4426	266	6	613	613	NUM
gs-4426	266	7	alternative	alternative	ADJ
gs-4426	266	8	payment	payment	NOUN
gs-4426	266	9	models	model	NOUN
gs-4426	266	10	have	have	AUX
gs-4426	266	11	been	be	AUX
gs-4426	266	12	proposed	propose	VERB
gs-4426	266	13	to	to	PART
gs-4426	266	14	address	address	VERB
gs-4426	266	15	the	the	DET
gs-4426	266	16	tension	tension	NOUN
gs-4426	266	17	between	between	ADP
gs-4426	266	18	upfront	upfront	ADJ
gs-4426	266	19	gene	gene	NOUN
gs-4426	266	20	therapy	therapy	NOUN
gs-4426	266	21	costs	cost	NOUN
gs-4426	266	22	and	and	CCONJ
gs-4426	266	23	uncertain	uncertain	ADJ
gs-4426	266	24	long	long	ADJ
gs-4426	266	25	-	-	PUNCT
gs-4426	266	26	term	term	NOUN
gs-4426	266	27	outcomes	outcome	NOUN
gs-4426	266	28	.	.	PUNCT
gs-4426	267	1	outcomes	outcome	NOUN
gs-4426	267	2	-	-	PUNCT
gs-4426	267	3	based	base	VERB
gs-4426	267	4	reimbursement	reimbursement	NOUN
gs-4426	267	5	,	,	PUNCT
gs-4426	267	6	where	where	SCONJ
gs-4426	267	7	payment	payment	NOUN
gs-4426	267	8	is	be	AUX
gs-4426	267	9	contingent	contingent	ADJ
gs-4426	267	10	on	on	ADP
gs-4426	267	11	achievement	achievement	NOUN
gs-4426	267	12	of	of	ADP
gs-4426	267	13	predefined	predefine	VERB
gs-4426	267	14	clinical	clinical	ADJ
gs-4426	267	15	endpoints	endpoint	NOUN
gs-4426	267	16	,	,	PUNCT
gs-4426	267	17	aims	aim	VERB
gs-4426	267	18	to	to	PART
gs-4426	267	19	align	align	VERB
gs-4426	267	20	manufacturer	manufacturer	NOUN
gs-4426	267	21	revenue	revenue	NOUN
gs-4426	267	22	with	with	ADP
gs-4426	267	23	therapeutic	therapeutic	ADJ
gs-4426	267	24	value	value	NOUN
gs-4426	267	25	delivery	delivery	NOUN
gs-4426	267	26	.	.	PUNCT
gs-4426	268	1	several	several	ADJ
gs-4426	268	2	gene	gene	NOUN
gs-4426	268	3	therapy	therapy	NOUN
gs-4426	268	4	manufacturers	manufacturer	NOUN
gs-4426	268	5	have	have	AUX
gs-4426	268	6	negotiated	negotiate	VERB
gs-4426	268	7	such	such	ADJ
gs-4426	268	8	arrangements	arrangement	NOUN
gs-4426	268	9	with	with	ADP
gs-4426	268	10	national	national	ADJ
gs-4426	268	11	health	health	NOUN
gs-4426	268	12	systems	system	NOUN
gs-4426	268	13	including	include	VERB
gs-4426	268	14	the	the	DET
gs-4426	268	15	uk	uk	PROPN
gs-4426	268	16	national	national	PROPN
gs-4426	268	17	health	health	PROPN
gs-4426	268	18	service	service	NOUN
gs-4426	268	19	and	and	CCONJ
gs-4426	268	20	us	us	PROPN
gs-4426	268	21	state	state	NOUN
gs-4426	268	22	medicaid	medicaid	PROPN
gs-4426	268	23	programs	program	NOUN
gs-4426	268	24	,	,	PUNCT
gs-4426	268	25	with	with	SCONJ
gs-4426	268	26	payment	payment	NOUN
gs-4426	268	27	structured	structure	VERB
gs-4426	268	28	as	as	ADP
gs-4426	268	29	installments	installment	NOUN
gs-4426	268	30	contingent	contingent	NOUN
gs-4426	268	31	on	on	ADP
gs-4426	268	32	maintained	maintain	VERB
gs-4426	268	33	therapeutic	therapeutic	ADJ
gs-4426	268	34	benefit	benefit	NOUN
gs-4426	268	35	at	at	ADP
gs-4426	268	36	defined	define	VERB
gs-4426	268	37	time	time	NOUN
gs-4426	268	38	points	point	NOUN
gs-4426	268	39	.	.	PUNCT
gs-4426	269	1	while	while	SCONJ
gs-4426	269	2	conceptually	conceptually	ADV
gs-4426	269	3	appealing	appeal	VERB
gs-4426	269	4	,	,	PUNCT
gs-4426	269	5	these	these	DET
gs-4426	269	6	models	model	NOUN
gs-4426	269	7	face	face	VERB
gs-4426	269	8	implementation	implementation	NOUN
gs-4426	269	9	challenges	challenge	NOUN
gs-4426	269	10	including	include	VERB
gs-4426	269	11	defining	define	VERB
gs-4426	269	12	appropriate	appropriate	ADJ
gs-4426	269	13	outcome	outcome	NOUN
gs-4426	269	14	measures	measure	NOUN
gs-4426	269	15	,	,	PUNCT
gs-4426	269	16	establishing	establish	VERB
gs-4426	269	17	monitoring	monitoring	NOUN
gs-4426	269	18	systems	system	NOUN
gs-4426	269	19	to	to	PART
gs-4426	269	20	assess	assess	VERB
gs-4426	269	21	outcomes	outcome	NOUN
gs-4426	269	22	over	over	ADP
gs-4426	269	23	extended	extended	ADJ
gs-4426	269	24	periods	period	NOUN
gs-4426	269	25	,	,	PUNCT
gs-4426	269	26	and	and	CCONJ
gs-4426	269	27	administrative	administrative	ADJ
gs-4426	269	28	complexity	complexity	NOUN
gs-4426	269	29	managing	manage	VERB
gs-4426	269	30	conditional	conditional	ADJ
gs-4426	269	31	payment	payment	NOUN
gs-4426	269	32	arrangements	arrangement	NOUN
gs-4426	269	33	.	.	PUNCT
gs-4426	270	1	annuity	annuity	NOUN
gs-4426	270	2	payment	payment	NOUN
gs-4426	270	3	structures	structure	NOUN
gs-4426	270	4	spreading	spread	VERB
gs-4426	270	5	costs	cost	NOUN
gs-4426	270	6	over	over	ADP
gs-4426	270	7	multiple	multiple	ADJ
gs-4426	270	8	years	year	NOUN
gs-4426	270	9	better	well	ADJ
gs-4426	270	10	align	align	VERB
gs-4426	270	11	gene	gene	NOUN
gs-4426	270	12	therapy	therapy	NOUN
gs-4426	270	13	payment	payment	NOUN
gs-4426	270	14	timelines	timeline	NOUN
gs-4426	270	15	with	with	ADP
gs-4426	270	16	conventional	conventional	ADJ
gs-4426	270	17	chronic	chronic	ADJ
gs-4426	270	18	therapy	therapy	NOUN
gs-4426	270	19	costs	cost	NOUN
gs-4426	270	20	,	,	PUNCT
gs-4426	270	21	potentially	potentially	ADV
gs-4426	270	22	reducing	reduce	VERB
gs-4426	270	23	budget	budget	NOUN
gs-4426	270	24	impact	impact	NOUN
gs-4426	270	25	and	and	CCONJ
gs-4426	270	26	improving	improve	VERB
gs-4426	270	27	affordability	affordability	NOUN
gs-4426	270	28	,	,	PUNCT
gs-4426	270	29	though	though	SCONJ
gs-4426	270	30	they	they	PRON
gs-4426	270	31	introduce	introduce	VERB
gs-4426	270	32	financial	financial	ADJ
gs-4426	270	33	risk	risk	NOUN
gs-4426	270	34	for	for	ADP
gs-4426	270	35	payers	payer	NOUN
gs-4426	270	36	if	if	SCONJ
gs-4426	270	37	patients	patient	NOUN
gs-4426	270	38	die	die	VERB
gs-4426	270	39	prematurely	prematurely	ADV
gs-4426	270	40	or	or	CCONJ
gs-4426	270	41	switch	switch	VERB
gs-4426	270	42	insurance	insurance	NOUN
gs-4426	270	43	plans	plan	NOUN
gs-4426	270	44	.	.	PUNCT
gs-4426	271	1	international	international	ADJ
gs-4426	271	2	disparities	disparity	NOUN
gs-4426	271	3	in	in	ADP
gs-4426	271	4	gene	gene	NOUN
gs-4426	271	5	therapy	therapy	NOUN
gs-4426	271	6	access	access	NOUN
gs-4426	271	7	represent	represent	VERB
gs-4426	271	8	another	another	DET
gs-4426	271	9	dimension	dimension	NOUN
gs-4426	271	10	of	of	ADP
gs-4426	271	11	economic	economic	ADJ
gs-4426	271	12	challenges	challenge	NOUN
gs-4426	271	13	,	,	PUNCT
gs-4426	271	14	with	with	ADP
gs-4426	271	15	most	most	ADV
gs-4426	271	16	approved	approve	VERB
gs-4426	271	17	products	product	NOUN
gs-4426	271	18	available	available	ADJ
gs-4426	271	19	only	only	ADV
gs-4426	271	20	in	in	ADP
gs-4426	271	21	wealthy	wealthy	ADJ
gs-4426	271	22	nations	nation	NOUN
gs-4426	271	23	while	while	SCONJ
gs-4426	271	24	low	low	ADJ
gs-4426	271	25	and	and	CCONJ
gs-4426	271	26	middleincome	middleincome	ADJ
gs-4426	271	27	countries	country	NOUN
gs-4426	271	28	where	where	SCONJ
gs-4426	271	29	disease	disease	NOUN
gs-4426	271	30	burdens	burden	NOUN
gs-4426	271	31	are	be	AUX
gs-4426	271	32	often	often	ADV
gs-4426	271	33	highest	high	ADJ
gs-4426	271	34	lack	lack	NOUN
gs-4426	271	35	access	access	NOUN
gs-4426	271	36	.	.	PUNCT
gs-4426	272	1	sickle	sickle	NOUN
gs-4426	272	2	cell	cell	NOUN
gs-4426	272	3	disease	disease	NOUN
gs-4426	272	4	disproportionately	disproportionately	ADV
gs-4426	272	5	affects	affect	VERB
gs-4426	272	6	populations	population	NOUN
gs-4426	272	7	in	in	ADP
gs-4426	272	8	sub	sub	ADJ
gs-4426	272	9	-	-	ADJ
gs-4426	272	10	saharan	saharan	ADJ
gs-4426	272	11	africa	africa	PROPN
gs-4426	272	12	and	and	CCONJ
gs-4426	272	13	india	india	PROPN
gs-4426	272	14	where	where	SCONJ
gs-4426	272	15	healthcare	healthcare	PROPN
gs-4426	272	16	resources	resource	NOUN
gs-4426	272	17	are	be	AUX
gs-4426	272	18	limited	limited	ADJ
gs-4426	272	19	and	and	CCONJ
gs-4426	272	20	current	current	ADJ
gs-4426	272	21	gene	gene	NOUN
gs-4426	272	22	therapy	therapy	NOUN
gs-4426	272	23	prices	price	NOUN
gs-4426	272	24	represent	represent	VERB
gs-4426	272	25	multiples	multiple	NOUN
gs-4426	272	26	of	of	ADP
gs-4426	272	27	annual	annual	ADJ
gs-4426	272	28	per	per	X
gs-4426	272	29	capita	capita	X
gs-4426	272	30	health	health	NOUN
gs-4426	272	31	expenditure	expenditure	NOUN
gs-4426	272	32	.	.	PUNCT
gs-4426	273	1	the	the	DET
gs-4426	273	2	absence	absence	NOUN
gs-4426	273	3	of	of	ADP
gs-4426	273	4	mechanisms	mechanism	NOUN
gs-4426	273	5	enabling	enable	VERB
gs-4426	273	6	affordable	affordable	ADJ
gs-4426	273	7	access	access	NOUN
gs-4426	273	8	to	to	ADP
gs-4426	273	9	gene	gene	NOUN
gs-4426	273	10	therapies	therapy	NOUN
gs-4426	273	11	in	in	ADP
gs-4426	273	12	resourcelimited	resourcelimite	VERB
gs-4426	273	13	settings	setting	NOUN
gs-4426	273	14	perpetuates	perpetuate	VERB
gs-4426	273	15	health	health	NOUN
gs-4426	273	16	inequities	inequity	NOUN
gs-4426	273	17	and	and	CCONJ
gs-4426	273	18	raises	raise	VERB
gs-4426	273	19	ethical	ethical	ADJ
gs-4426	273	20	concerns	concern	NOUN
gs-4426	273	21	about	about	ADP
gs-4426	273	22	innovations	innovation	NOUN
gs-4426	273	23	funded	fund	VERB
gs-4426	273	24	partially	partially	ADV
gs-4426	273	25	through	through	ADP
gs-4426	273	26	public	public	ADJ
gs-4426	273	27	research	research	NOUN
gs-4426	273	28	investment	investment	NOUN
gs-4426	273	29	being	be	AUX
gs-4426	273	30	available	available	ADJ
gs-4426	273	31	only	only	ADV
gs-4426	273	32	to	to	ADP
gs-4426	273	33	wealthy	wealthy	ADJ
gs-4426	273	34	populations	population	NOUN
gs-4426	273	35	.	.	PUNCT
gs-4426	274	1	technology	technology	NOUN
gs-4426	274	2	transfer	transfer	NOUN
gs-4426	274	3	initiatives	initiative	NOUN
gs-4426	274	4	enabling	enable	VERB
gs-4426	274	5	local	local	ADJ
gs-4426	274	6	manufacturing	manufacturing	NOUN
gs-4426	274	7	,	,	PUNCT
gs-4426	274	8	tiered	tiere	VERB
gs-4426	274	9	pricing	pricing	NOUN
gs-4426	274	10	strategies	strategy	NOUN
gs-4426	274	11	with	with	ADP
gs-4426	274	12	differential	differential	ADJ
gs-4426	274	13	pricing	pricing	NOUN
gs-4426	274	14	across	across	ADP
gs-4426	274	15	markets	market	NOUN
gs-4426	274	16	based	base	VERB
gs-4426	274	17	on	on	ADP
gs-4426	274	18	ability	ability	NOUN
gs-4426	274	19	to	to	PART
gs-4426	274	20	pay	pay	VERB
gs-4426	274	21	,	,	PUNCT
gs-4426	274	22	and	and	CCONJ
gs-4426	274	23	development	development	NOUN
gs-4426	274	24	of	of	ADP
gs-4426	274	25	simplified	simplified	ADJ
gs-4426	274	26	lower	low	ADJ
gs-4426	274	27	-	-	PUNCT
gs-4426	274	28	cost	cost	NOUN
gs-4426	274	29	gene	gene	NOUN
gs-4426	274	30	therapy	therapy	NOUN
gs-4426	274	31	platforms	platform	NOUN
gs-4426	274	32	represent	represent	VERB
gs-4426	274	33	potential	potential	ADJ
gs-4426	274	34	approaches	approach	NOUN
gs-4426	274	35	to	to	PART
gs-4426	274	36	enhance	enhance	VERB
gs-4426	274	37	global	global	ADJ
gs-4426	274	38	accessibility	accessibility	NOUN
gs-4426	274	39	,	,	PUNCT
gs-4426	274	40	though	though	SCONJ
gs-4426	274	41	pharmaceutical	pharmaceutical	NOUN
gs-4426	274	42	industry	industry	NOUN
gs-4426	274	43	reluctance	reluctance	NOUN
gs-4426	274	44	to	to	PART
gs-4426	274	45	reduce	reduce	VERB
gs-4426	274	46	prices	price	NOUN
gs-4426	274	47	in	in	ADP
gs-4426	274	48	any	any	DET
gs-4426	274	49	market	market	NOUN
gs-4426	274	50	due	due	ADP
gs-4426	274	51	to	to	ADP
gs-4426	274	52	concerns	concern	NOUN
gs-4426	274	53	about	about	ADP
gs-4426	274	54	price	price	NOUN
gs-4426	274	55	referencing	referencing	NOUN
gs-4426	274	56	and	and	CCONJ
gs-4426	274	57	parallel	parallel	ADJ
gs-4426	274	58	importation	importation	NOUN
gs-4426	274	59	has	have	AUX
gs-4426	274	60	limited	limit	VERB
gs-4426	274	61	implementation	implementation	NOUN
gs-4426	274	62	of	of	ADP
gs-4426	274	63	such	such	ADJ
gs-4426	274	64	strategies	strategy	NOUN
gs-4426	274	65	.	.	PUNCT
gs-4426	275	1	societal	societal	ADJ
gs-4426	275	2	and	and	CCONJ
gs-4426	275	3	ethical	ethical	ADJ
gs-4426	275	4	dimensions	dimension	NOUN
gs-4426	275	5	the	the	DET
gs-4426	275	6	advancement	advancement	NOUN
gs-4426	275	7	of	of	ADP
gs-4426	275	8	gene	gene	NOUN
gs-4426	275	9	therapy	therapy	NOUN
gs-4426	275	10	raises	raise	VERB
gs-4426	275	11	profound	profound	ADJ
gs-4426	275	12	ethical	ethical	ADJ
gs-4426	275	13	questions	question	NOUN
gs-4426	275	14	requiring	require	VERB
gs-4426	275	15	societal	societal	ADJ
gs-4426	275	16	deliberation	deliberation	NOUN
gs-4426	275	17	and	and	CCONJ
gs-4426	275	18	consensus	consensus	NOUN
gs-4426	275	19	-	-	PUNCT
gs-4426	275	20	building	building	NOUN
gs-4426	275	21	.	.	PUNCT
gs-4426	276	1	the	the	DET
gs-4426	276	2	capability	capability	NOUN
gs-4426	276	3	to	to	PART
gs-4426	276	4	permanently	permanently	ADV
gs-4426	276	5	alter	alter	VERB
gs-4426	276	6	human	human	ADJ
gs-4426	276	7	genetic	genetic	ADJ
gs-4426	276	8	material	material	NOUN
gs-4426	276	9	,	,	PUNCT
gs-4426	276	10	particularly	particularly	ADV
gs-4426	276	11	when	when	SCONJ
gs-4426	276	12	delivered	deliver	VERB
gs-4426	276	13	in	in	ADP
gs-4426	276	14	vivo	vivo	NOUN
gs-4426	276	15	where	where	SCONJ
gs-4426	276	16	off	off	ADP
gs-4426	276	17	-	-	PUNCT
gs-4426	276	18	target	target	NOUN
gs-4426	276	19	effects	effect	NOUN
gs-4426	276	20	in	in	ADP
gs-4426	276	21	germline	germline	NOUN
gs-4426	276	22	tissues	tissue	NOUN
gs-4426	276	23	remain	remain	VERB
gs-4426	276	24	theoretically	theoretically	ADV
gs-4426	276	25	possible	possible	ADJ
gs-4426	276	26	despite	despite	SCONJ
gs-4426	276	27	being	be	AUX
gs-4426	276	28	extremely	extremely	ADV
gs-4426	276	29	unlikely	unlikely	ADJ
gs-4426	276	30	,	,	PUNCT
gs-4426	276	31	evokes	evoke	VERB
gs-4426	276	32	concerns	concern	NOUN
gs-4426	276	33	about	about	ADP
gs-4426	276	34	unintended	unintended	ADJ
gs-4426	276	35	consequences	consequence	NOUN
gs-4426	276	36	and	and	CCONJ
gs-4426	276	37	playing	play	VERB
gs-4426	276	38	with	with	ADP
gs-4426	276	39	fundamental	fundamental	ADJ
gs-4426	276	40	aspects	aspect	NOUN
gs-4426	276	41	of	of	ADP
gs-4426	276	42	human	human	ADJ
gs-4426	276	43	biology	biology	NOUN
gs-4426	276	44	.	.	PUNCT
gs-4426	277	1	while	while	SCONJ
gs-4426	277	2	therapeutic	therapeutic	ADJ
gs-4426	277	3	genome	genome	NOUN
gs-4426	277	4	editing	editing	NOUN
gs-4426	277	5	in	in	ADP
gs-4426	277	6	somatic	somatic	ADJ
gs-4426	277	7	cells	cell	NOUN
gs-4426	277	8	to	to	PART
gs-4426	277	9	treat	treat	VERB
gs-4426	277	10	serious	serious	ADJ
gs-4426	277	11	diseases	disease	NOUN
gs-4426	277	12	enjoys	enjoy	VERB
gs-4426	277	13	broad	broad	ADJ
gs-4426	277	14	ethical	ethical	ADJ
gs-4426	277	15	acceptance	acceptance	NOUN
gs-4426	277	16	,	,	PUNCT
gs-4426	277	17	the	the	DET
gs-4426	277	18	line	line	NOUN
gs-4426	277	19	between	between	ADP
gs-4426	277	20	therapy	therapy	NOUN
gs-4426	277	21	and	and	CCONJ
gs-4426	277	22	enhancement	enhancement	NOUN
gs-4426	277	23	remains	remain	VERB
gs-4426	277	24	subject	subject	ADJ
gs-4426	277	25	to	to	ADP
gs-4426	277	26	debate	debate	NOUN
gs-4426	277	27	,	,	PUNCT
gs-4426	277	28	particularly	particularly	ADV
gs-4426	277	29	as	as	SCONJ
gs-4426	277	30	gene	gene	NOUN
gs-4426	277	31	therapy	therapy	NOUN
gs-4426	277	32	applications	application	NOUN
gs-4426	277	33	expand	expand	VERB
gs-4426	277	34	toward	toward	ADP
gs-4426	277	35	common	common	ADJ
gs-4426	277	36	diseases	disease	NOUN
gs-4426	277	37	and	and	CCONJ
gs-4426	277	38	risk	risk	NOUN
gs-4426	277	39	factor	factor	NOUN
gs-4426	277	40	modification	modification	NOUN
gs-4426	277	41	in	in	ADP
gs-4426	277	42	generally	generally	ADV
gs-4426	277	43	healthy	healthy	ADJ
gs-4426	277	44	individuals	individual	NOUN
gs-4426	277	45	.	.	PUNCT
gs-4426	278	1	the	the	DET
gs-4426	278	2	question	question	NOUN
gs-4426	278	3	of	of	ADP
gs-4426	278	4	when	when	SCONJ
gs-4426	278	5	preventive	preventive	ADJ
gs-4426	278	6	genetic	genetic	ADJ
gs-4426	278	7	modification	modification	NOUN
gs-4426	278	8	is	be	AUX
gs-4426	278	9	justified	justify	VERB
gs-4426	278	10	—	—	PUNCT
gs-4426	278	11	whether	whether	SCONJ
gs-4426	278	12	only	only	ADV
gs-4426	278	13	for	for	ADP
gs-4426	278	14	monogenic	monogenic	ADJ
gs-4426	278	15	diseases	disease	NOUN
gs-4426	278	16	with	with	ADP
gs-4426	278	17	high	high	ADJ
gs-4426	278	18	penetrance	penetrance	NOUN
gs-4426	278	19	and	and	CCONJ
gs-4426	278	20	severe	severe	ADJ
gs-4426	278	21	outcomes	outcome	NOUN
gs-4426	278	22	or	or	CCONJ
gs-4426	278	23	also	also	ADV
gs-4426	278	24	for	for	ADP
gs-4426	278	25	polygenic	polygenic	ADJ
gs-4426	278	26	risk	risk	NOUN
gs-4426	278	27	factors	factor	NOUN
gs-4426	278	28	conferring	confer	VERB
gs-4426	278	29	modest	modest	ADJ
gs-4426	278	30	disease	disease	NOUN
gs-4426	278	31	probability	probability	NOUN
gs-4426	278	32	increases	increase	NOUN
gs-4426	278	33	—	—	PUNCT
gs-4426	278	34	lacks	lack	VERB
gs-4426	278	35	consensus	consensus	NOUN
gs-4426	278	36	and	and	CCONJ
gs-4426	278	37	may	may	AUX
gs-4426	278	38	require	require	VERB
gs-4426	278	39	regulatory	regulatory	ADJ
gs-4426	278	40	guidance	guidance	NOUN
gs-4426	278	41	as	as	SCONJ
gs-4426	278	42	technologies	technology	NOUN
gs-4426	278	43	enable	enable	VERB
gs-4426	278	44	increasingly	increasingly	ADV
gs-4426	278	45	diverse	diverse	ADJ
gs-4426	278	46	applications	application	NOUN
gs-4426	278	47	.	.	PUNCT
gs-4426	279	1	issues	issue	NOUN
gs-4426	279	2	of	of	ADP
gs-4426	279	3	justice	justice	NOUN
gs-4426	279	4	and	and	CCONJ
gs-4426	279	5	equitable	equitable	ADJ
gs-4426	279	6	access	access	NOUN
gs-4426	279	7	represent	represent	VERB
gs-4426	279	8	another	another	DET
gs-4426	279	9	critical	critical	ADJ
gs-4426	279	10	ethical	ethical	ADJ
gs-4426	279	11	dimension	dimension	NOUN
gs-4426	279	12	,	,	PUNCT
gs-4426	279	13	as	as	ADP
gs-4426	279	14	the	the	DET
gs-4426	279	15	extreme	extreme	ADJ
gs-4426	279	16	costs	cost	NOUN
gs-4426	279	17	of	of	ADP
gs-4426	279	18	gene	gene	NOUN
gs-4426	279	19	therapies	therapy	NOUN
gs-4426	279	20	risk	risk	NOUN
gs-4426	279	21	creating	create	VERB
gs-4426	279	22	a	a	DET
gs-4426	279	23	two	two	NUM
gs-4426	279	24	-	-	PUNCT
gs-4426	279	25	tier	tier	NOUN
gs-4426	279	26	healthcare	healthcare	NOUN
gs-4426	279	27	system	system	NOUN
gs-4426	279	28	where	where	SCONJ
gs-4426	279	29	potentially	potentially	ADV
gs-4426	279	30	curative	curative	ADJ
gs-4426	279	31	treatments	treatment	NOUN
gs-4426	279	32	are	be	AUX
gs-4426	279	33	available	available	ADJ
gs-4426	279	34	only	only	ADV
gs-4426	279	35	to	to	ADP
gs-4426	279	36	wealthy	wealthy	ADJ
gs-4426	279	37	individuals	individual	NOUN
gs-4426	279	38	while	while	SCONJ
gs-4426	279	39	others	other	NOUN
gs-4426	279	40	continue	continue	VERB
gs-4426	279	41	receiving	receive	VERB
gs-4426	279	42	inferior	inferior	ADJ
gs-4426	279	43	georgian	georgian	NOUN
gs-4426	279	44	scientists/	scientists/	NUM
gs-4426	279	45	.	.	PUNCT
gs-4426	280	1	7	7	NUM
gs-4426	280	2	n	n	DET
gs-4426	280	3	4	4	NUM
gs-4426	280	4	,	,	PUNCT
gs-4426	280	5	2025	2025	NUM
gs-4426	280	6	614	614	NUM
gs-4426	280	7	conventional	conventional	ADJ
gs-4426	280	8	therapies	therapy	NOUN
gs-4426	280	9	.	.	PUNCT
gs-4426	281	1	the	the	DET
gs-4426	281	2	concentration	concentration	NOUN
gs-4426	281	3	of	of	ADP
gs-4426	281	4	gene	gene	NOUN
gs-4426	281	5	therapy	therapy	NOUN
gs-4426	281	6	development	development	NOUN
gs-4426	281	7	and	and	CCONJ
gs-4426	281	8	availability	availability	NOUN
gs-4426	281	9	in	in	ADP
gs-4426	281	10	highincome	highincome	ADJ
gs-4426	281	11	countries	country	NOUN
gs-4426	281	12	while	while	SCONJ
gs-4426	281	13	populations	population	NOUN
gs-4426	281	14	in	in	ADP
gs-4426	281	15	low	low	ADJ
gs-4426	281	16	and	and	CCONJ
gs-4426	281	17	middle	middle	ADJ
gs-4426	281	18	-	-	PUNCT
gs-4426	281	19	income	income	NOUN
gs-4426	281	20	countries	country	NOUN
gs-4426	281	21	bearing	bear	VERB
gs-4426	281	22	the	the	DET
gs-4426	281	23	greatest	great	ADJ
gs-4426	281	24	disease	disease	NOUN
gs-4426	281	25	burdens	burden	NOUN
gs-4426	281	26	lack	lack	VERB
gs-4426	281	27	access	access	NOUN
gs-4426	281	28	raises	raise	VERB
gs-4426	281	29	fundamental	fundamental	ADJ
gs-4426	281	30	questions	question	NOUN
gs-4426	281	31	about	about	ADP
gs-4426	281	32	health	health	NOUN
gs-4426	281	33	equity	equity	NOUN
gs-4426	281	34	and	and	CCONJ
gs-4426	281	35	the	the	DET
gs-4426	281	36	obligations	obligation	NOUN
gs-4426	281	37	of	of	ADP
gs-4426	281	38	innovators	innovator	NOUN
gs-4426	281	39	,	,	PUNCT
gs-4426	281	40	governments	government	NOUN
gs-4426	281	41	,	,	PUNCT
gs-4426	281	42	and	and	CCONJ
gs-4426	281	43	international	international	ADJ
gs-4426	281	44	organizations	organization	NOUN
gs-4426	281	45	to	to	PART
gs-4426	281	46	ensure	ensure	VERB
gs-4426	281	47	global	global	ADJ
gs-4426	281	48	benefit	benefit	NOUN
gs-4426	281	49	from	from	ADP
gs-4426	281	50	scientific	scientific	ADJ
gs-4426	281	51	advances	advance	NOUN
gs-4426	281	52	.	.	PUNCT
gs-4426	282	1	the	the	DET
gs-4426	282	2	funding	funding	NOUN
gs-4426	282	3	of	of	ADP
gs-4426	282	4	basic	basic	ADJ
gs-4426	282	5	research	research	NOUN
gs-4426	282	6	underlying	underlie	VERB
gs-4426	282	7	gene	gene	NOUN
gs-4426	282	8	therapy	therapy	NOUN
gs-4426	282	9	innovations	innovation	NOUN
gs-4426	282	10	through	through	ADP
gs-4426	282	11	public	public	ADJ
gs-4426	282	12	resources	resource	NOUN
gs-4426	282	13	including	include	VERB
gs-4426	282	14	national	national	ADJ
gs-4426	282	15	institutes	institutes	PROPN
gs-4426	282	16	of	of	ADP
gs-4426	282	17	health	health	NOUN
gs-4426	282	18	grants	grant	NOUN
gs-4426	282	19	and	and	CCONJ
gs-4426	282	20	academic	academic	ADJ
gs-4426	282	21	infrastructure	infrastructure	NOUN
gs-4426	282	22	,	,	PUNCT
gs-4426	282	23	subsequently	subsequently	ADV
gs-4426	282	24	licensed	license	VERB
gs-4426	282	25	to	to	ADP
gs-4426	282	26	commercial	commercial	ADJ
gs-4426	282	27	entities	entity	NOUN
gs-4426	282	28	that	that	PRON
gs-4426	282	29	price	price	NOUN
gs-4426	282	30	products	product	NOUN
gs-4426	282	31	at	at	ADP
gs-4426	282	32	levels	level	NOUN
gs-4426	282	33	inaccessible	inaccessible	ADJ
gs-4426	282	34	to	to	ADP
gs-4426	282	35	many	many	ADJ
gs-4426	282	36	,	,	PUNCT
gs-4426	282	37	prompts	prompt	NOUN
gs-4426	282	38	debate	debate	VERB
gs-4426	282	39	about	about	ADP
gs-4426	282	40	appropriate	appropriate	ADJ
gs-4426	282	41	return	return	NOUN
gs-4426	282	42	on	on	ADP
gs-4426	282	43	public	public	ADJ
gs-4426	282	44	investment	investment	NOUN
gs-4426	282	45	and	and	CCONJ
gs-4426	282	46	whether	whether	SCONJ
gs-4426	282	47	licensing	licensing	NOUN
gs-4426	282	48	agreements	agreement	NOUN
gs-4426	282	49	should	should	AUX
gs-4426	282	50	include	include	VERB
gs-4426	282	51	affordability	affordability	NOUN
gs-4426	282	52	provisions	provision	NOUN
gs-4426	282	53	.	.	PUNCT
gs-4426	283	1	informed	inform	VERB
gs-4426	283	2	consent	consent	NOUN
gs-4426	283	3	for	for	ADP
gs-4426	283	4	gene	gene	NOUN
gs-4426	283	5	therapy	therapy	NOUN
gs-4426	283	6	poses	pose	VERB
gs-4426	283	7	unique	unique	ADJ
gs-4426	283	8	challenges	challenge	NOUN
gs-4426	283	9	given	give	VERB
gs-4426	283	10	the	the	DET
gs-4426	283	11	novel	novel	ADJ
gs-4426	283	12	nature	nature	NOUN
gs-4426	283	13	of	of	ADP
gs-4426	283	14	genetic	genetic	ADJ
gs-4426	283	15	interventions	intervention	NOUN
gs-4426	283	16	,	,	PUNCT
gs-4426	283	17	long	long	ADJ
gs-4426	283	18	-	-	PUNCT
gs-4426	283	19	term	term	NOUN
gs-4426	283	20	uncertainties	uncertainty	NOUN
gs-4426	283	21	regarding	regard	VERB
gs-4426	283	22	safety	safety	NOUN
gs-4426	283	23	and	and	CCONJ
gs-4426	283	24	efficacy	efficacy	NOUN
gs-4426	283	25	,	,	PUNCT
gs-4426	283	26	and	and	CCONJ
gs-4426	283	27	complexity	complexity	NOUN
gs-4426	283	28	of	of	ADP
gs-4426	283	29	explaining	explain	VERB
gs-4426	283	30	sophisticated	sophisticated	ADJ
gs-4426	283	31	molecular	molecular	ADJ
gs-4426	283	32	biology	biology	NOUN
gs-4426	283	33	concepts	concept	NOUN
gs-4426	283	34	to	to	ADP
gs-4426	283	35	patients	patient	NOUN
gs-4426	283	36	and	and	CCONJ
gs-4426	283	37	families	family	NOUN
gs-4426	283	38	facing	face	VERB
gs-4426	283	39	serious	serious	ADJ
gs-4426	283	40	diseases	disease	NOUN
gs-4426	283	41	.	.	PUNCT
gs-4426	284	1	regulatory	regulatory	ADJ
gs-4426	284	2	requirements	requirement	NOUN
gs-4426	284	3	mandate	mandate	VERB
gs-4426	284	4	comprehensive	comprehensive	ADJ
gs-4426	284	5	informed	inform	VERB
gs-4426	284	6	consent	consent	NOUN
gs-4426	284	7	processes	process	NOUN
gs-4426	284	8	covering	cover	VERB
gs-4426	284	9	intervention	intervention	NOUN
gs-4426	284	10	mechanisms	mechanism	NOUN
gs-4426	284	11	,	,	PUNCT
gs-4426	284	12	potential	potential	ADJ
gs-4426	284	13	benefits	benefit	NOUN
gs-4426	284	14	and	and	CCONJ
gs-4426	284	15	risks	risk	NOUN
gs-4426	284	16	,	,	PUNCT
gs-4426	284	17	alternative	alternative	ADJ
gs-4426	284	18	treatment	treatment	NOUN
gs-4426	284	19	options	option	NOUN
gs-4426	284	20	,	,	PUNCT
gs-4426	284	21	and	and	CCONJ
gs-4426	284	22	long	long	ADJ
gs-4426	284	23	-	-	PUNCT
gs-4426	284	24	term	term	NOUN
gs-4426	284	25	follow	follow	NOUN
gs-4426	284	26	-	-	PUNCT
gs-4426	284	27	up	up	ADP
gs-4426	284	28	obligations	obligation	NOUN
gs-4426	284	29	.	.	PUNCT
gs-4426	285	1	however	however	ADV
gs-4426	285	2	,	,	PUNCT
gs-4426	285	3	research	research	NOUN
gs-4426	285	4	consistently	consistently	ADV
gs-4426	285	5	demonstrates	demonstrate	VERB
gs-4426	285	6	that	that	DET
gs-4426	285	7	patient	patient	ADJ
gs-4426	285	8	comprehension	comprehension	NOUN
gs-4426	285	9	of	of	ADP
gs-4426	285	10	complex	complex	ADJ
gs-4426	285	11	medical	medical	ADJ
gs-4426	285	12	information	information	NOUN
gs-4426	285	13	is	be	AUX
gs-4426	285	14	imperfect	imperfect	ADJ
gs-4426	285	15	,	,	PUNCT
gs-4426	285	16	particularly	particularly	ADV
gs-4426	285	17	in	in	ADP
gs-4426	285	18	emotionally	emotionally	ADV
gs-4426	285	19	charged	charge	VERB
gs-4426	285	20	circumstances	circumstance	NOUN
gs-4426	285	21	when	when	SCONJ
gs-4426	285	22	parents	parent	NOUN
gs-4426	285	23	are	be	AUX
gs-4426	285	24	making	make	VERB
gs-4426	285	25	decisions	decision	NOUN
gs-4426	285	26	for	for	ADP
gs-4426	285	27	seriously	seriously	ADV
gs-4426	285	28	ill	ill	ADJ
gs-4426	285	29	children	child	NOUN
gs-4426	285	30	.	.	PUNCT
gs-4426	286	1	the	the	DET
gs-4426	286	2	therapeutic	therapeutic	ADJ
gs-4426	286	3	misconception	misconception	NOUN
gs-4426	286	4	—	—	PUNCT
gs-4426	286	5	patients	patient	NOUN
gs-4426	286	6	'	'	PART
gs-4426	286	7	tendency	tendency	NOUN
gs-4426	286	8	to	to	PART
gs-4426	286	9	overestimate	overestimate	VERB
gs-4426	286	10	potential	potential	ADJ
gs-4426	286	11	benefits	benefit	NOUN
gs-4426	286	12	and	and	CCONJ
gs-4426	286	13	underestimate	underestimate	ADJ
gs-4426	286	14	risks	risk	NOUN
gs-4426	286	15	when	when	SCONJ
gs-4426	286	16	desperate	desperate	ADJ
gs-4426	286	17	for	for	ADP
gs-4426	286	18	treatment	treatment	NOUN
gs-4426	286	19	options	option	NOUN
gs-4426	286	20	—	—	PUNCT
gs-4426	286	21	represents	represent	VERB
gs-4426	286	22	another	another	DET
gs-4426	286	23	concern	concern	NOUN
gs-4426	286	24	,	,	PUNCT
gs-4426	286	25	potentially	potentially	ADV
gs-4426	286	26	leading	lead	VERB
gs-4426	286	27	to	to	ADP
gs-4426	286	28	unrealistic	unrealistic	ADJ
gs-4426	286	29	expectations	expectation	NOUN
gs-4426	286	30	and	and	CCONJ
gs-4426	286	31	inadequate	inadequate	ADJ
gs-4426	286	32	appreciation	appreciation	NOUN
gs-4426	286	33	of	of	ADP
gs-4426	286	34	uncertainties	uncertainty	NOUN
gs-4426	286	35	.	.	PUNCT
gs-4426	287	1	enhanced	enhance	VERB
gs-4426	287	2	consent	consent	NOUN
gs-4426	287	3	processes	process	NOUN
gs-4426	287	4	incorporating	incorporate	VERB
gs-4426	287	5	decision	decision	NOUN
gs-4426	287	6	aids	aid	NOUN
gs-4426	287	7	,	,	PUNCT
gs-4426	287	8	repeated	repeat	VERB
gs-4426	287	9	discussions	discussion	NOUN
gs-4426	287	10	,	,	PUNCT
gs-4426	287	11	and	and	CCONJ
gs-4426	287	12	involvement	involvement	NOUN
gs-4426	287	13	of	of	ADP
gs-4426	287	14	patient	patient	ADJ
gs-4426	287	15	advocates	advocate	NOUN
gs-4426	287	16	may	may	AUX
gs-4426	287	17	improve	improve	VERB
gs-4426	287	18	understanding	understanding	NOUN
gs-4426	287	19	while	while	SCONJ
gs-4426	287	20	respecting	respect	VERB
gs-4426	287	21	patient	patient	ADJ
gs-4426	287	22	autonomy	autonomy	NOUN
gs-4426	287	23	.	.	PUNCT
gs-4426	288	1	the	the	DET
gs-4426	288	2	prospect	prospect	NOUN
gs-4426	288	3	of	of	ADP
gs-4426	288	4	inheritable	inheritable	ADJ
gs-4426	288	5	genome	genome	NOUN
gs-4426	288	6	editing	editing	NOUN
gs-4426	288	7	,	,	PUNCT
gs-4426	288	8	enabling	enable	VERB
gs-4426	288	9	permanent	permanent	ADJ
gs-4426	288	10	changes	change	NOUN
gs-4426	288	11	transmissible	transmissible	ADJ
gs-4426	288	12	to	to	ADP
gs-4426	288	13	future	future	ADJ
gs-4426	288	14	generations	generation	NOUN
gs-4426	288	15	,	,	PUNCT
gs-4426	288	16	raises	raise	VERB
gs-4426	288	17	even	even	ADV
gs-4426	288	18	more	more	ADV
gs-4426	288	19	profound	profound	ADJ
gs-4426	288	20	ethical	ethical	ADJ
gs-4426	288	21	questions	question	NOUN
gs-4426	288	22	despite	despite	SCONJ
gs-4426	288	23	remaining	remain	VERB
gs-4426	288	24	clearly	clearly	ADV
gs-4426	288	25	separated	separate	VERB
gs-4426	288	26	from	from	ADP
gs-4426	288	27	current	current	ADJ
gs-4426	288	28	therapeutic	therapeutic	ADJ
gs-4426	288	29	somatic	somatic	ADJ
gs-4426	288	30	gene	gene	NOUN
gs-4426	288	31	therapy	therapy	NOUN
gs-4426	288	32	.	.	PUNCT
gs-4426	289	1	the	the	DET
gs-4426	289	2	international	international	ADJ
gs-4426	289	3	outcry	outcry	NOUN
gs-4426	289	4	following	follow	VERB
gs-4426	289	5	disclosure	disclosure	NOUN
gs-4426	289	6	that	that	SCONJ
gs-4426	289	7	a	a	DET
gs-4426	289	8	researcher	researcher	NOUN
gs-4426	289	9	in	in	ADP
gs-4426	289	10	china	china	PROPN
gs-4426	289	11	had	have	AUX
gs-4426	289	12	used	use	VERB
gs-4426	289	13	crispr	crispr	PROPN
gs-4426	289	14	to	to	PART
gs-4426	289	15	edit	edit	VERB
gs-4426	289	16	human	human	ADJ
gs-4426	289	17	embryos	embryo	NOUN
gs-4426	289	18	implanted	implant	VERB
gs-4426	289	19	for	for	ADP
gs-4426	289	20	pregnancy	pregnancy	NOUN
gs-4426	289	21	,	,	PUNCT
gs-4426	289	22	resulting	result	VERB
gs-4426	289	23	in	in	ADP
gs-4426	289	24	the	the	DET
gs-4426	289	25	birth	birth	NOUN
gs-4426	289	26	of	of	ADP
gs-4426	289	27	genetically	genetically	ADV
gs-4426	289	28	modified	modify	VERB
gs-4426	289	29	twins	twin	NOUN
gs-4426	289	30	,	,	PUNCT
gs-4426	289	31	demonstrated	demonstrate	VERB
gs-4426	289	32	the	the	DET
gs-4426	289	33	lack	lack	NOUN
gs-4426	289	34	of	of	ADP
gs-4426	289	35	ethical	ethical	ADJ
gs-4426	289	36	consensus	consensus	NOUN
gs-4426	289	37	regarding	regard	VERB
gs-4426	289	38	germline	germline	NOUN
gs-4426	289	39	editing	editing	NOUN
gs-4426	289	40	and	and	CCONJ
gs-4426	289	41	led	lead	VERB
gs-4426	289	42	to	to	ADP
gs-4426	289	43	calls	call	NOUN
gs-4426	289	44	for	for	ADP
gs-4426	289	45	international	international	ADJ
gs-4426	289	46	governance	governance	NOUN
gs-4426	289	47	frameworks	framework	NOUN
gs-4426	289	48	.	.	PUNCT
gs-4426	290	1	while	while	SCONJ
gs-4426	290	2	heritable	heritable	ADJ
gs-4426	290	3	genome	genome	NOUN
gs-4426	290	4	editing	editing	NOUN
gs-4426	290	5	might	might	AUX
gs-4426	290	6	theoretically	theoretically	ADV
gs-4426	290	7	prevent	prevent	VERB
gs-4426	290	8	transmission	transmission	NOUN
gs-4426	290	9	of	of	ADP
gs-4426	290	10	devastating	devastating	ADJ
gs-4426	290	11	genetic	genetic	ADJ
gs-4426	290	12	diseases	disease	NOUN
gs-4426	290	13	to	to	ADP
gs-4426	290	14	offspring	offspring	NOUN
gs-4426	290	15	,	,	PUNCT
gs-4426	290	16	the	the	DET
gs-4426	290	17	irreversibility	irreversibility	NOUN
gs-4426	290	18	of	of	ADP
gs-4426	290	19	changes	change	NOUN
gs-4426	290	20	affecting	affect	VERB
gs-4426	290	21	future	future	ADJ
gs-4426	290	22	generations	generation	NOUN
gs-4426	290	23	without	without	ADP
gs-4426	290	24	their	their	PRON
gs-4426	290	25	consent	consent	NOUN
gs-4426	290	26	,	,	PUNCT
gs-4426	290	27	potential	potential	NOUN
gs-4426	290	28	for	for	ADP
gs-4426	290	29	unintended	unintended	ADJ
gs-4426	290	30	consequences	consequence	NOUN
gs-4426	290	31	affecting	affect	VERB
gs-4426	290	32	human	human	ADJ
gs-4426	290	33	gene	gene	NOUN
gs-4426	290	34	pools	pool	NOUN
gs-4426	290	35	,	,	PUNCT
gs-4426	290	36	and	and	CCONJ
gs-4426	290	37	inability	inability	NOUN
gs-4426	290	38	to	to	PART
gs-4426	290	39	obtain	obtain	VERB
gs-4426	290	40	informed	informed	ADJ
gs-4426	290	41	consent	consent	NOUN
gs-4426	290	42	from	from	ADP
gs-4426	290	43	affected	affected	ADJ
gs-4426	290	44	future	future	ADJ
gs-4426	290	45	individuals	individual	NOUN
gs-4426	290	46	create	create	VERB
gs-4426	290	47	ethical	ethical	ADJ
gs-4426	290	48	obstacles	obstacle	NOUN
gs-4426	290	49	that	that	PRON
gs-4426	290	50	most	most	ADJ
gs-4426	290	51	authorities	authority	NOUN
gs-4426	290	52	consider	consider	VERB
gs-4426	290	53	insurmountable	insurmountable	ADJ
gs-4426	290	54	under	under	ADP
gs-4426	290	55	current	current	ADJ
gs-4426	290	56	knowledge	knowledge	NOUN
gs-4426	290	57	.	.	PUNCT
gs-4426	291	1	the	the	DET
gs-4426	291	2	clear	clear	ADJ
gs-4426	291	3	distinction	distinction	NOUN
gs-4426	291	4	between	between	ADP
gs-4426	291	5	somatic	somatic	ADJ
gs-4426	291	6	therapy	therapy	NOUN
gs-4426	291	7	and	and	CCONJ
gs-4426	291	8	germline	germline	NOUN
gs-4426	291	9	modification	modification	NOUN
gs-4426	291	10	must	must	AUX
gs-4426	291	11	be	be	AUX
gs-4426	291	12	maintained	maintain	VERB
gs-4426	291	13	through	through	ADP
gs-4426	291	14	regulatory	regulatory	ADJ
gs-4426	291	15	oversight	oversight	NOUN
gs-4426	291	16	and	and	CCONJ
gs-4426	291	17	professional	professional	ADJ
gs-4426	291	18	ethical	ethical	ADJ
gs-4426	291	19	standards	standard	NOUN
gs-4426	291	20	.	.	PUNCT
gs-4426	292	1	conclusions	conclusion	NOUN
gs-4426	292	2	the	the	DET
gs-4426	292	3	rapid	rapid	ADJ
gs-4426	292	4	evolution	evolution	NOUN
gs-4426	292	5	of	of	ADP
gs-4426	292	6	gene	gene	NOUN
gs-4426	292	7	therapy	therapy	NOUN
gs-4426	292	8	from	from	ADP
gs-4426	292	9	an	an	DET
gs-4426	292	10	experimental	experimental	ADJ
gs-4426	292	11	concept	concept	NOUN
gs-4426	292	12	into	into	ADP
gs-4426	292	13	a	a	DET
gs-4426	292	14	clinically	clinically	ADV
gs-4426	292	15	validated	validate	VERB
gs-4426	292	16	and	and	CCONJ
gs-4426	292	17	regulatory	regulatory	ADV
gs-4426	292	18	-	-	PUNCT
gs-4426	292	19	approved	approve	VERB
gs-4426	292	20	therapeutic	therapeutic	ADJ
gs-4426	292	21	modality	modality	NOUN
gs-4426	292	22	represents	represent	VERB
gs-4426	292	23	one	one	NUM
gs-4426	292	24	of	of	ADP
gs-4426	292	25	the	the	DET
gs-4426	292	26	most	most	ADV
gs-4426	292	27	profound	profound	ADJ
gs-4426	292	28	paradigm	paradigm	NOUN
gs-4426	292	29	shifts	shift	NOUN
gs-4426	292	30	in	in	ADP
gs-4426	292	31	modern	modern	ADJ
gs-4426	292	32	biomedical	biomedical	ADJ
gs-4426	292	33	science	science	NOUN
gs-4426	292	34	.	.	PUNCT
gs-4426	293	1	the	the	DET
gs-4426	293	2	cumulative	cumulative	ADJ
gs-4426	293	3	evidence	evidence	NOUN
gs-4426	293	4	synthesized	synthesize	VERB
gs-4426	293	5	in	in	ADP
gs-4426	293	6	this	this	DET
gs-4426	293	7	comprehensive	comprehensive	ADJ
gs-4426	293	8	analysis	analysis	NOUN
gs-4426	293	9	demonstrates	demonstrate	VERB
gs-4426	293	10	that	that	SCONJ
gs-4426	293	11	gene	gene	NOUN
gs-4426	293	12	therapy	therapy	NOUN
gs-4426	293	13	has	have	AUX
gs-4426	293	14	decisively	decisively	ADV
gs-4426	293	15	crossed	cross	VERB
gs-4426	293	16	the	the	DET
gs-4426	293	17	threshold	threshold	NOUN
gs-4426	293	18	from	from	ADP
gs-4426	293	19	theoretical	theoretical	ADJ
gs-4426	293	20	promise	promise	NOUN
gs-4426	293	21	to	to	ADP
gs-4426	293	22	tangible	tangible	ADJ
gs-4426	293	23	clinical	clinical	ADJ
gs-4426	293	24	reality	reality	NOUN
gs-4426	293	25	,	,	PUNCT
gs-4426	293	26	offering	offer	VERB
gs-4426	293	27	durable	durable	ADJ
gs-4426	293	28	and	and	CCONJ
gs-4426	293	29	,	,	PUNCT
gs-4426	293	30	in	in	ADP
gs-4426	293	31	some	some	DET
gs-4426	293	32	cases	case	NOUN
gs-4426	293	33	,	,	PUNCT
gs-4426	293	34	curative	curative	ADJ
gs-4426	293	35	outcomes	outcome	NOUN
gs-4426	293	36	for	for	ADP
gs-4426	293	37	diseases	disease	NOUN
gs-4426	293	38	that	that	PRON
gs-4426	293	39	were	be	AUX
gs-4426	293	40	previously	previously	ADV
gs-4426	293	41	georgian	georgian	ADJ
gs-4426	293	42	scientists/	scientists/	NUM
gs-4426	293	43	.	.	PUNCT
gs-4426	294	1	7	7	NUM
gs-4426	294	2	n	n	DET
gs-4426	294	3	4	4	NUM
gs-4426	294	4	,	,	PUNCT
gs-4426	294	5	2025	2025	NUM
gs-4426	294	6	615	615	NUM
gs-4426	294	7	considered	consider	VERB
gs-4426	294	8	intractable	intractable	ADJ
gs-4426	294	9	.	.	PUNCT
gs-4426	295	1	landmark	landmark	PROPN
gs-4426	295	2	regulatory	regulatory	ADJ
gs-4426	295	3	approvals	approval	NOUN
gs-4426	295	4	,	,	PUNCT
gs-4426	295	5	including	include	VERB
gs-4426	295	6	the	the	DET
gs-4426	295	7	first	first	ADJ
gs-4426	295	8	crisprbased	crisprbase	VERB
gs-4426	295	9	gene	gene	NOUN
gs-4426	295	10	editing	edit	VERB
gs-4426	295	11	therapy	therapy	NOUN
gs-4426	295	12	and	and	CCONJ
gs-4426	295	13	the	the	DET
gs-4426	295	14	continued	continue	VERB
gs-4426	295	15	expansion	expansion	NOUN
gs-4426	295	16	of	of	ADP
gs-4426	295	17	car	car	NOUN
gs-4426	295	18	-	-	PUNCT
gs-4426	295	19	t	t	NOUN
gs-4426	295	20	and	and	CCONJ
gs-4426	295	21	viral	viral	ADJ
gs-4426	295	22	vectorbased	vectorbase	VERB
gs-4426	295	23	treatments	treatment	NOUN
gs-4426	295	24	,	,	PUNCT
gs-4426	295	25	underscore	underscore	VERB
gs-4426	295	26	the	the	DET
gs-4426	295	27	maturity	maturity	NOUN
gs-4426	295	28	of	of	ADP
gs-4426	295	29	the	the	DET
gs-4426	295	30	field	field	NOUN
gs-4426	295	31	and	and	CCONJ
gs-4426	295	32	validate	validate	VERB
gs-4426	295	33	decades	decade	NOUN
gs-4426	295	34	of	of	ADP
gs-4426	295	35	foundational	foundational	ADJ
gs-4426	295	36	research	research	NOUN
gs-4426	295	37	in	in	ADP
gs-4426	295	38	molecular	molecular	ADJ
gs-4426	295	39	genetics	genetic	NOUN
gs-4426	295	40	,	,	PUNCT
gs-4426	295	41	virology	virology	NOUN
gs-4426	295	42	,	,	PUNCT
gs-4426	295	43	immunology	immunology	NOUN
gs-4426	295	44	,	,	PUNCT
gs-4426	295	45	and	and	CCONJ
gs-4426	295	46	translational	translational	ADJ
gs-4426	295	47	medicine	medicine	NOUN
gs-4426	295	48	.	.	PUNCT
gs-4426	296	1	clinical	clinical	ADJ
gs-4426	296	2	successes	success	NOUN
gs-4426	296	3	in	in	ADP
gs-4426	296	4	monogenic	monogenic	ADJ
gs-4426	296	5	disorders	disorder	NOUN
gs-4426	296	6	such	such	ADJ
gs-4426	296	7	as	as	ADP
gs-4426	296	8	sickle	sickle	NOUN
gs-4426	296	9	cell	cell	NOUN
gs-4426	296	10	disease	disease	NOUN
gs-4426	296	11	,	,	PUNCT
gs-4426	296	12	beta	beta	NOUN
gs-4426	296	13	-	-	PUNCT
gs-4426	296	14	thalassemia	thalassemia	NOUN
gs-4426	296	15	,	,	PUNCT
gs-4426	296	16	hemophilia	hemophilia	PROPN
gs-4426	296	17	,	,	PUNCT
gs-4426	296	18	and	and	CCONJ
gs-4426	296	19	inherited	inherit	VERB
gs-4426	296	20	retinal	retinal	ADJ
gs-4426	296	21	dystrophies	dystrophy	NOUN
gs-4426	296	22	provide	provide	VERB
gs-4426	296	23	compelling	compelling	ADJ
gs-4426	296	24	proof	proof	NOUN
gs-4426	296	25	-	-	PUNCT
gs-4426	296	26	of	of	ADP
gs-4426	296	27	-	-	PUNCT
gs-4426	296	28	concept	concept	NOUN
gs-4426	296	29	that	that	SCONJ
gs-4426	296	30	precise	precise	ADJ
gs-4426	296	31	genetic	genetic	ADJ
gs-4426	296	32	interventions	intervention	NOUN
gs-4426	296	33	can	can	AUX
gs-4426	296	34	correct	correct	VERB
gs-4426	296	35	underlying	underlie	VERB
gs-4426	296	36	disease	disease	NOUN
gs-4426	296	37	mechanisms	mechanism	NOUN
gs-4426	296	38	rather	rather	ADV
gs-4426	296	39	than	than	ADP
gs-4426	296	40	merely	merely	ADV
gs-4426	296	41	mitigating	mitigate	VERB
gs-4426	296	42	symptoms	symptom	NOUN
gs-4426	296	43	.	.	PUNCT
gs-4426	297	1	these	these	DET
gs-4426	297	2	achievements	achievement	NOUN
gs-4426	297	3	have	have	AUX
gs-4426	297	4	redefined	redefine	VERB
gs-4426	297	5	therapeutic	therapeutic	ADJ
gs-4426	297	6	expectations	expectation	NOUN
gs-4426	297	7	,	,	PUNCT
gs-4426	297	8	shifting	shift	VERB
gs-4426	297	9	the	the	DET
gs-4426	297	10	clinical	clinical	ADJ
gs-4426	297	11	goal	goal	NOUN
gs-4426	297	12	from	from	ADP
gs-4426	297	13	chronic	chronic	ADJ
gs-4426	297	14	disease	disease	NOUN
gs-4426	297	15	management	management	NOUN
gs-4426	297	16	toward	toward	ADP
gs-4426	297	17	longterm	longterm	ADJ
gs-4426	297	18	disease	disease	NOUN
gs-4426	297	19	modification	modification	NOUN
gs-4426	297	20	or	or	CCONJ
gs-4426	297	21	functional	functional	ADJ
gs-4426	297	22	cure	cure	NOUN
gs-4426	297	23	.	.	PUNCT
gs-4426	298	1	the	the	DET
gs-4426	298	2	parallel	parallel	ADJ
gs-4426	298	3	advancement	advancement	NOUN
gs-4426	298	4	of	of	ADP
gs-4426	298	5	engineered	engineer	VERB
gs-4426	298	6	cell	cell	NOUN
gs-4426	298	7	therapies	therapy	NOUN
gs-4426	298	8	,	,	PUNCT
gs-4426	298	9	particularly	particularly	ADV
gs-4426	298	10	car	car	NOUN
gs-4426	298	11	-	-	PUNCT
gs-4426	298	12	t	t	PROPN
gs-4426	298	13	,	,	PUNCT
gs-4426	298	14	tcr	tcr	PROPN
gs-4426	298	15	,	,	PUNCT
gs-4426	298	16	and	and	CCONJ
gs-4426	298	17	til	til	ADV
gs-4426	298	18	-	-	PUNCT
gs-4426	298	19	based	base	VERB
gs-4426	298	20	approaches	approach	NOUN
gs-4426	298	21	,	,	PUNCT
gs-4426	298	22	has	have	AUX
gs-4426	298	23	transformed	transform	VERB
gs-4426	298	24	oncology	oncology	NOUN
gs-4426	298	25	practice	practice	NOUN
gs-4426	298	26	and	and	CCONJ
gs-4426	298	27	is	be	AUX
gs-4426	298	28	increasingly	increasingly	ADV
gs-4426	298	29	demonstrating	demonstrate	VERB
gs-4426	298	30	potential	potential	ADJ
gs-4426	298	31	beyond	beyond	ADP
gs-4426	298	32	cancer	cancer	NOUN
gs-4426	298	33	,	,	PUNCT
gs-4426	298	34	including	include	VERB
gs-4426	298	35	in	in	ADP
gs-4426	298	36	autoimmune	autoimmune	ADJ
gs-4426	298	37	and	and	CCONJ
gs-4426	298	38	inflammatory	inflammatory	ADJ
gs-4426	298	39	diseases	disease	NOUN
gs-4426	298	40	.	.	PUNCT
gs-4426	299	1	together	together	ADV
gs-4426	299	2	,	,	PUNCT
gs-4426	299	3	these	these	DET
gs-4426	299	4	developments	development	NOUN
gs-4426	299	5	establish	establish	VERB
gs-4426	299	6	gene	gene	NOUN
gs-4426	299	7	and	and	CCONJ
gs-4426	299	8	cell	cell	NOUN
gs-4426	299	9	therapy	therapy	NOUN
gs-4426	299	10	as	as	ADP
gs-4426	299	11	foundational	foundational	ADJ
gs-4426	299	12	pillars	pillar	NOUN
gs-4426	299	13	of	of	ADP
gs-4426	299	14	precision	precision	NOUN
gs-4426	299	15	and	and	CCONJ
gs-4426	299	16	personalized	personalized	ADJ
gs-4426	299	17	medicine	medicine	NOUN
gs-4426	299	18	.	.	PUNCT
gs-4426	300	1	at	at	ADP
gs-4426	300	2	the	the	DET
gs-4426	300	3	technological	technological	ADJ
gs-4426	300	4	level	level	NOUN
gs-4426	300	5	,	,	PUNCT
gs-4426	300	6	diversification	diversification	NOUN
gs-4426	300	7	of	of	ADP
gs-4426	300	8	therapeutic	therapeutic	ADJ
gs-4426	300	9	platforms	platform	NOUN
gs-4426	300	10	—	—	PUNCT
gs-4426	300	11	including	include	VERB
gs-4426	300	12	adenoassociated	adenoassociate	VERB
gs-4426	300	13	viral	viral	ADJ
gs-4426	300	14	vectors	vector	NOUN
gs-4426	300	15	,	,	PUNCT
gs-4426	300	16	lentiviral	lentiviral	ADJ
gs-4426	300	17	systems	system	NOUN
gs-4426	300	18	,	,	PUNCT
gs-4426	300	19	crispr	crispr	NOUN
gs-4426	300	20	-	-	PUNCT
gs-4426	300	21	cas	cas	NOUN
gs-4426	300	22	genome	genome	NOUN
gs-4426	300	23	editing	editing	NOUN
gs-4426	300	24	,	,	PUNCT
gs-4426	300	25	base	base	NOUN
gs-4426	300	26	and	and	CCONJ
gs-4426	300	27	prime	prime	ADJ
gs-4426	300	28	editors	editor	NOUN
gs-4426	300	29	,	,	PUNCT
gs-4426	300	30	and	and	CCONJ
gs-4426	300	31	rna	rna	NOUN
gs-4426	300	32	-	-	PUNCT
gs-4426	300	33	based	base	VERB
gs-4426	300	34	strategies	strategy	NOUN
gs-4426	300	35	—	—	PUNCT
gs-4426	300	36	has	have	AUX
gs-4426	300	37	expanded	expand	VERB
gs-4426	300	38	the	the	DET
gs-4426	300	39	range	range	NOUN
gs-4426	300	40	of	of	ADP
gs-4426	300	41	treatable	treatable	ADJ
gs-4426	300	42	diseases	disease	NOUN
gs-4426	300	43	and	and	CCONJ
gs-4426	300	44	enabled	enable	VERB
gs-4426	300	45	tailoring	tailoring	NOUN
gs-4426	300	46	of	of	ADP
gs-4426	300	47	approaches	approach	NOUN
gs-4426	300	48	to	to	ADP
gs-4426	300	49	specific	specific	ADJ
gs-4426	300	50	biological	biological	ADJ
gs-4426	300	51	contexts	contexts	NOUN
gs-4426	300	52	.	.	PUNCT
gs-4426	301	1	the	the	DET
gs-4426	301	2	convergence	convergence	NOUN
gs-4426	301	3	of	of	ADP
gs-4426	301	4	gene	gene	NOUN
gs-4426	301	5	editing	edit	VERB
gs-4426	301	6	with	with	ADP
gs-4426	301	7	advanced	advanced	ADJ
gs-4426	301	8	delivery	delivery	NOUN
gs-4426	301	9	systems	system	NOUN
gs-4426	301	10	,	,	PUNCT
gs-4426	301	11	automated	automate	VERB
gs-4426	301	12	manufacturing	manufacturing	NOUN
gs-4426	301	13	,	,	PUNCT
gs-4426	301	14	and	and	CCONJ
gs-4426	301	15	computational	computational	ADJ
gs-4426	301	16	optimization	optimization	NOUN
gs-4426	301	17	has	have	AUX
gs-4426	301	18	significantly	significantly	ADV
gs-4426	301	19	improved	improve	VERB
gs-4426	301	20	safety	safety	NOUN
gs-4426	301	21	,	,	PUNCT
gs-4426	301	22	efficiency	efficiency	NOUN
gs-4426	301	23	,	,	PUNCT
gs-4426	301	24	and	and	CCONJ
gs-4426	301	25	reproducibility	reproducibility	NOUN
gs-4426	301	26	.	.	PUNCT
gs-4426	302	1	however	however	ADV
gs-4426	302	2	,	,	PUNCT
gs-4426	302	3	despite	despite	SCONJ
gs-4426	302	4	this	this	DET
gs-4426	302	5	progress	progress	NOUN
gs-4426	302	6	,	,	PUNCT
gs-4426	302	7	substantial	substantial	ADJ
gs-4426	302	8	scientific	scientific	ADJ
gs-4426	302	9	and	and	CCONJ
gs-4426	302	10	translational	translational	ADJ
gs-4426	302	11	challenges	challenge	NOUN
gs-4426	302	12	persist	persist	VERB
gs-4426	302	13	,	,	PUNCT
gs-4426	302	14	particularly	particularly	ADV
gs-4426	302	15	related	relate	VERB
gs-4426	302	16	to	to	ADP
gs-4426	302	17	immunogenicity	immunogenicity	NOUN
gs-4426	302	18	,	,	PUNCT
gs-4426	302	19	off	off	ADP
gs-4426	302	20	-	-	PUNCT
gs-4426	302	21	target	target	NOUN
gs-4426	302	22	effects	effect	NOUN
gs-4426	302	23	,	,	PUNCT
gs-4426	302	24	durability	durability	NOUN
gs-4426	302	25	of	of	ADP
gs-4426	302	26	gene	gene	NOUN
gs-4426	302	27	expression	expression	NOUN
gs-4426	302	28	,	,	PUNCT
gs-4426	302	29	and	and	CCONJ
gs-4426	302	30	the	the	DET
gs-4426	302	31	complexity	complexity	NOUN
gs-4426	302	32	of	of	ADP
gs-4426	302	33	treating	treat	VERB
gs-4426	302	34	polygenic	polygenic	ADJ
gs-4426	302	35	and	and	CCONJ
gs-4426	302	36	multifactorial	multifactorial	ADJ
gs-4426	302	37	diseases	disease	NOUN
gs-4426	302	38	.	.	PUNCT
gs-4426	303	1	equally	equally	ADV
gs-4426	303	2	significant	significant	ADJ
gs-4426	303	3	are	be	AUX
gs-4426	303	4	the	the	DET
gs-4426	303	5	systemic	systemic	ADJ
gs-4426	303	6	barriers	barrier	NOUN
gs-4426	303	7	that	that	PRON
gs-4426	303	8	threaten	threaten	VERB
gs-4426	303	9	to	to	PART
gs-4426	303	10	limit	limit	VERB
gs-4426	303	11	the	the	DET
gs-4426	303	12	broad	broad	ADJ
gs-4426	303	13	societal	societal	ADJ
gs-4426	303	14	impact	impact	NOUN
gs-4426	303	15	of	of	ADP
gs-4426	303	16	gene	gene	NOUN
gs-4426	303	17	therapy	therapy	NOUN
gs-4426	303	18	.	.	PUNCT
gs-4426	304	1	high	high	ADJ
gs-4426	304	2	treatment	treatment	NOUN
gs-4426	304	3	costs	cost	NOUN
gs-4426	304	4	,	,	PUNCT
gs-4426	304	5	manufacturing	manufacturing	NOUN
gs-4426	304	6	bottlenecks	bottleneck	NOUN
gs-4426	304	7	,	,	PUNCT
gs-4426	304	8	limited	limited	ADJ
gs-4426	304	9	infrastructure	infrastructure	NOUN
gs-4426	304	10	,	,	PUNCT
gs-4426	304	11	and	and	CCONJ
gs-4426	304	12	disparities	disparity	NOUN
gs-4426	304	13	in	in	ADP
gs-4426	304	14	global	global	ADJ
gs-4426	304	15	access	access	NOUN
gs-4426	304	16	pose	pose	VERB
gs-4426	304	17	critical	critical	ADJ
gs-4426	304	18	challenges	challenge	NOUN
gs-4426	304	19	to	to	PART
gs-4426	304	20	equitable	equitable	VERB
gs-4426	304	21	implementation	implementation	NOUN
gs-4426	304	22	.	.	PUNCT
gs-4426	305	1	while	while	SCONJ
gs-4426	305	2	single	single	ADJ
gs-4426	305	3	-	-	PUNCT
gs-4426	305	4	administration	administration	NOUN
gs-4426	305	5	therapies	therapy	NOUN
gs-4426	305	6	may	may	AUX
gs-4426	305	7	be	be	AUX
gs-4426	305	8	cost	cost	NOUN
gs-4426	305	9	-	-	PUNCT
gs-4426	305	10	effective	effective	ADJ
gs-4426	305	11	over	over	ADP
gs-4426	305	12	a	a	DET
gs-4426	305	13	lifetime	lifetime	NOUN
gs-4426	305	14	,	,	PUNCT
gs-4426	305	15	their	their	PRON
gs-4426	305	16	concentrated	concentrated	ADJ
gs-4426	305	17	upfront	upfront	ADJ
gs-4426	305	18	expense	expense	NOUN
gs-4426	305	19	strains	strain	VERB
gs-4426	305	20	existing	exist	VERB
gs-4426	305	21	reimbursement	reimbursement	NOUN
gs-4426	305	22	models	model	NOUN
gs-4426	305	23	and	and	CCONJ
gs-4426	305	24	raises	raise	VERB
gs-4426	305	25	ethical	ethical	ADJ
gs-4426	305	26	and	and	CCONJ
gs-4426	305	27	policy	policy	NOUN
gs-4426	305	28	questions	question	NOUN
gs-4426	305	29	regarding	regard	VERB
gs-4426	305	30	affordability	affordability	NOUN
gs-4426	305	31	and	and	CCONJ
gs-4426	305	32	prioritization	prioritization	NOUN
gs-4426	305	33	.	.	PUNCT
gs-4426	306	1	furthermore	furthermore	ADV
gs-4426	306	2	,	,	PUNCT
gs-4426	306	3	the	the	DET
gs-4426	306	4	expansion	expansion	NOUN
gs-4426	306	5	of	of	ADP
gs-4426	306	6	gene	gene	NOUN
gs-4426	306	7	therapy	therapy	NOUN
gs-4426	306	8	into	into	ADP
gs-4426	306	9	common	common	ADJ
gs-4426	306	10	diseases	disease	NOUN
gs-4426	306	11	with	with	ADP
gs-4426	306	12	large	large	ADJ
gs-4426	306	13	patient	patient	ADJ
gs-4426	306	14	populations	population	NOUN
gs-4426	306	15	necessitates	necessitate	VERB
gs-4426	306	16	a	a	DET
gs-4426	306	17	recalibration	recalibration	NOUN
gs-4426	306	18	of	of	ADP
gs-4426	306	19	safety	safety	NOUN
gs-4426	306	20	thresholds	threshold	NOUN
gs-4426	306	21	,	,	PUNCT
gs-4426	306	22	regulatory	regulatory	ADJ
gs-4426	306	23	frameworks	framework	NOUN
gs-4426	306	24	,	,	PUNCT
gs-4426	306	25	and	and	CCONJ
gs-4426	306	26	long	long	ADJ
gs-4426	306	27	-	-	PUNCT
gs-4426	306	28	term	term	NOUN
gs-4426	306	29	surveillance	surveillance	NOUN
gs-4426	306	30	strategies	strategy	NOUN
gs-4426	306	31	.	.	PUNCT
gs-4426	307	1	the	the	DET
gs-4426	307	2	gene	gene	NOUN
gs-4426	307	3	therapy	therapy	NOUN
gs-4426	307	4	stands	stand	VERB
gs-4426	307	5	at	at	ADP
gs-4426	307	6	a	a	DET
gs-4426	307	7	pivotal	pivotal	ADJ
gs-4426	307	8	inflection	inflection	NOUN
gs-4426	307	9	point	point	NOUN
gs-4426	307	10	.	.	PUNCT
gs-4426	308	1	the	the	DET
gs-4426	308	2	field	field	NOUN
gs-4426	308	3	has	have	AUX
gs-4426	308	4	demonstrated	demonstrate	VERB
gs-4426	308	5	undeniable	undeniable	ADJ
gs-4426	308	6	clinical	clinical	ADJ
gs-4426	308	7	efficacy	efficacy	NOUN
gs-4426	308	8	and	and	CCONJ
gs-4426	308	9	technological	technological	ADJ
gs-4426	308	10	robustness	robustness	NOUN
gs-4426	308	11	,	,	PUNCT
gs-4426	308	12	yet	yet	CCONJ
gs-4426	308	13	its	its	PRON
gs-4426	308	14	future	future	ADJ
gs-4426	308	15	impact	impact	NOUN
gs-4426	308	16	will	will	AUX
gs-4426	308	17	depend	depend	VERB
gs-4426	308	18	on	on	ADP
gs-4426	308	19	the	the	DET
gs-4426	308	20	successful	successful	ADJ
gs-4426	308	21	integration	integration	NOUN
gs-4426	308	22	of	of	ADP
gs-4426	308	23	scientific	scientific	ADJ
gs-4426	308	24	innovation	innovation	NOUN
gs-4426	308	25	with	with	ADP
gs-4426	308	26	scalable	scalable	ADJ
gs-4426	308	27	manufacturing	manufacturing	NOUN
gs-4426	308	28	,	,	PUNCT
gs-4426	308	29	sustainable	sustainable	ADJ
gs-4426	308	30	economic	economic	ADJ
gs-4426	308	31	models	model	NOUN
gs-4426	308	32	,	,	PUNCT
gs-4426	308	33	adaptive	adaptive	ADJ
gs-4426	308	34	regulatory	regulatory	ADJ
gs-4426	308	35	oversight	oversight	NOUN
gs-4426	308	36	,	,	PUNCT
gs-4426	308	37	and	and	CCONJ
gs-4426	308	38	ethical	ethical	ADJ
gs-4426	308	39	stewardship	stewardship	NOUN
gs-4426	308	40	.	.	PUNCT
gs-4426	309	1	if	if	SCONJ
gs-4426	309	2	these	these	DET
gs-4426	309	3	challenges	challenge	NOUN
gs-4426	309	4	are	be	AUX
gs-4426	309	5	addressed	address	VERB
gs-4426	309	6	through	through	ADP
gs-4426	309	7	coordinated	coordinate	VERB
gs-4426	309	8	multidisciplinary	multidisciplinary	ADJ
gs-4426	309	9	efforts	effort	NOUN
gs-4426	309	10	,	,	PUNCT
gs-4426	309	11	gene	gene	NOUN
gs-4426	309	12	therapy	therapy	NOUN
gs-4426	309	13	has	have	VERB
gs-4426	309	14	the	the	DET
gs-4426	309	15	potential	potential	NOUN
gs-4426	309	16	not	not	PART
gs-4426	309	17	only	only	ADV
gs-4426	309	18	to	to	PART
gs-4426	309	19	redefine	redefine	VERB
gs-4426	309	20	treatment	treatment	NOUN
gs-4426	309	21	paradigms	paradigm	NOUN
gs-4426	309	22	across	across	ADP
gs-4426	309	23	multiple	multiple	ADJ
gs-4426	309	24	disease	disease	NOUN
gs-4426	309	25	domains	domain	NOUN
gs-4426	309	26	but	but	CCONJ
gs-4426	309	27	also	also	ADV
gs-4426	309	28	to	to	PART
gs-4426	309	29	fundamentally	fundamentally	ADV
gs-4426	309	30	reshape	reshape	VERB
gs-4426	309	31	the	the	DET
gs-4426	309	32	future	future	ADJ
gs-4426	309	33	georgian	georgian	NOUN
gs-4426	309	34	scientists/	scientists/	NUM
gs-4426	309	35	.	.	PUNCT
gs-4426	310	1	7	7	NUM
gs-4426	310	2	n	n	DET
gs-4426	310	3	4	4	NUM
gs-4426	310	4	,	,	PUNCT
gs-4426	310	5	2025	2025	NUM
gs-4426	310	6	616	616	NUM
gs-4426	310	7	of	of	ADP
gs-4426	310	8	medicine	medicine	NOUN
gs-4426	310	9	by	by	ADP
gs-4426	310	10	enabling	enable	VERB
gs-4426	310	11	durable	durable	ADJ
gs-4426	310	12	,	,	PUNCT
gs-4426	310	13	mechanism	mechanism	NOUN
gs-4426	310	14	-	-	PUNCT
gs-4426	310	15	based	base	VERB
gs-4426	310	16	,	,	PUNCT
gs-4426	310	17	and	and	CCONJ
gs-4426	310	18	patient	patient	NOUN
gs-4426	310	19	-	-	PUNCT
gs-4426	310	20	centered	center	VERB
gs-4426	310	21	interventions	intervention	NOUN
gs-4426	310	22	.	.	PUNCT
gs-4426	311	1	1.2	1.2	NUM
gs-4426	311	2	.	.	PUNCT
gs-4426	311	3	recommendations	recommendation	NOUN
gs-4426	311	4	to	to	PART
gs-4426	311	5	ensure	ensure	VERB
gs-4426	311	6	the	the	DET
gs-4426	311	7	sustainable	sustainable	ADJ
gs-4426	311	8	advancement	advancement	NOUN
gs-4426	311	9	and	and	CCONJ
gs-4426	311	10	equitable	equitable	ADJ
gs-4426	311	11	integration	integration	NOUN
gs-4426	311	12	of	of	ADP
gs-4426	311	13	gene	gene	NOUN
gs-4426	311	14	therapy	therapy	NOUN
gs-4426	311	15	into	into	ADP
gs-4426	311	16	routine	routine	ADJ
gs-4426	311	17	clinical	clinical	ADJ
gs-4426	311	18	practice	practice	NOUN
gs-4426	311	19	,	,	PUNCT
gs-4426	311	20	several	several	ADJ
gs-4426	311	21	strategic	strategic	ADJ
gs-4426	311	22	priorities	priority	NOUN
gs-4426	311	23	should	should	AUX
gs-4426	311	24	be	be	AUX
gs-4426	311	25	addressed	address	VERB
gs-4426	311	26	across	across	ADP
gs-4426	311	27	scientific	scientific	ADJ
gs-4426	311	28	,	,	PUNCT
gs-4426	311	29	clinical	clinical	ADJ
gs-4426	311	30	,	,	PUNCT
gs-4426	311	31	regulatory	regulatory	ADJ
gs-4426	311	32	,	,	PUNCT
gs-4426	311	33	and	and	CCONJ
gs-4426	311	34	policy	policy	NOUN
gs-4426	311	35	domains	domain	NOUN
gs-4426	311	36	.	.	PUNCT
gs-4426	312	1	the	the	DET
gs-4426	312	2	continued	continue	VERB
gs-4426	312	3	investment	investment	NOUN
gs-4426	312	4	in	in	ADP
gs-4426	312	5	next	next	ADJ
gs-4426	312	6	-	-	PUNCT
gs-4426	312	7	generation	generation	NOUN
gs-4426	312	8	gene	gene	NOUN
gs-4426	312	9	editing	editing	NOUN
gs-4426	312	10	technologies	technology	NOUN
gs-4426	312	11	is	be	AUX
gs-4426	312	12	essential	essential	ADJ
gs-4426	312	13	.	.	PUNCT
gs-4426	313	1	research	research	NOUN
gs-4426	313	2	efforts	effort	NOUN
gs-4426	313	3	should	should	AUX
gs-4426	313	4	prioritize	prioritize	VERB
gs-4426	313	5	the	the	DET
gs-4426	313	6	refinement	refinement	NOUN
gs-4426	313	7	of	of	ADP
gs-4426	313	8	base	base	NOUN
gs-4426	313	9	editing	editing	NOUN
gs-4426	313	10	,	,	PUNCT
gs-4426	313	11	prime	prime	ADJ
gs-4426	313	12	editing	editing	NOUN
gs-4426	313	13	,	,	PUNCT
gs-4426	313	14	and	and	CCONJ
gs-4426	313	15	epigenome	epigenome	NOUN
gs-4426	313	16	-	-	PUNCT
gs-4426	313	17	modulating	modulate	VERB
gs-4426	313	18	tools	tool	NOUN
gs-4426	313	19	that	that	PRON
gs-4426	313	20	offer	offer	VERB
gs-4426	313	21	enhanced	enhanced	ADJ
gs-4426	313	22	precision	precision	NOUN
gs-4426	313	23	and	and	CCONJ
gs-4426	313	24	reduced	reduce	VERB
gs-4426	313	25	genotoxic	genotoxic	ADJ
gs-4426	313	26	risk	risk	NOUN
gs-4426	313	27	compared	compare	VERB
gs-4426	313	28	with	with	ADP
gs-4426	313	29	nuclease	nuclease	NOUN
gs-4426	313	30	-	-	PUNCT
gs-4426	313	31	based	base	VERB
gs-4426	313	32	systems	system	NOUN
gs-4426	313	33	.	.	PUNCT
gs-4426	314	1	parallel	parallel	ADJ
gs-4426	314	2	development	development	NOUN
gs-4426	314	3	of	of	ADP
gs-4426	314	4	tissue	tissue	NOUN
gs-4426	314	5	-	-	PUNCT
gs-4426	314	6	specific	specific	ADJ
gs-4426	314	7	and	and	CCONJ
gs-4426	314	8	immune	immune	NOUN
gs-4426	314	9	-	-	PUNCT
gs-4426	314	10	evasive	evasive	ADJ
gs-4426	314	11	delivery	delivery	NOUN
gs-4426	314	12	platforms	platform	NOUN
gs-4426	314	13	,	,	PUNCT
gs-4426	314	14	including	include	VERB
gs-4426	314	15	engineered	engineer	VERB
gs-4426	314	16	viral	viral	ADJ
gs-4426	314	17	capsids	capsid	NOUN
gs-4426	314	18	,	,	PUNCT
gs-4426	314	19	lipid	lipid	NOUN
gs-4426	314	20	nanoparticles	nanoparticle	NOUN
gs-4426	314	21	,	,	PUNCT
gs-4426	314	22	and	and	CCONJ
gs-4426	314	23	non	non	ADJ
gs-4426	314	24	-	-	ADJ
gs-4426	314	25	viral	viral	ADJ
gs-4426	314	26	vectors	vector	NOUN
gs-4426	314	27	,	,	PUNCT
gs-4426	314	28	will	will	AUX
gs-4426	314	29	be	be	AUX
gs-4426	314	30	critical	critical	ADJ
gs-4426	314	31	for	for	ADP
gs-4426	314	32	expanding	expand	VERB
gs-4426	314	33	in	in	ADP
gs-4426	314	34	vivo	vivo	ADJ
gs-4426	314	35	applications	application	NOUN
gs-4426	314	36	beyond	beyond	ADP
gs-4426	314	37	currently	currently	ADV
gs-4426	314	38	accessible	accessible	ADJ
gs-4426	314	39	organs	organ	NOUN
gs-4426	314	40	and	and	CCONJ
gs-4426	314	41	minimizing	minimize	VERB
gs-4426	314	42	immunological	immunological	ADJ
gs-4426	314	43	barriers	barrier	NOUN
gs-4426	314	44	.	.	PUNCT
gs-4426	315	1	manufacturing	manufacturing	NOUN
gs-4426	315	2	innovation	innovation	NOUN
gs-4426	315	3	must	must	AUX
gs-4426	315	4	be	be	AUX
gs-4426	315	5	recognized	recognize	VERB
gs-4426	315	6	as	as	ADP
gs-4426	315	7	a	a	DET
gs-4426	315	8	central	central	ADJ
gs-4426	315	9	enabler	enabler	NOUN
gs-4426	315	10	of	of	ADP
gs-4426	315	11	clinical	clinical	ADJ
gs-4426	315	12	translation	translation	NOUN
gs-4426	315	13	rather	rather	ADV
gs-4426	315	14	than	than	ADP
gs-4426	315	15	a	a	DET
gs-4426	315	16	downstream	downstream	ADJ
gs-4426	315	17	technical	technical	ADJ
gs-4426	315	18	consideration	consideration	NOUN
gs-4426	315	19	.	.	PUNCT
gs-4426	316	1	the	the	DET
gs-4426	316	2	adoption	adoption	NOUN
gs-4426	316	3	of	of	ADP
gs-4426	316	4	closed	closed	ADJ
gs-4426	316	5	,	,	PUNCT
gs-4426	316	6	automated	automate	VERB
gs-4426	316	7	,	,	PUNCT
gs-4426	316	8	and	and	CCONJ
gs-4426	316	9	modular	modular	ADJ
gs-4426	316	10	manufacturing	manufacturing	NOUN
gs-4426	316	11	systems	system	NOUN
gs-4426	316	12	should	should	AUX
gs-4426	316	13	be	be	AUX
gs-4426	316	14	accelerated	accelerate	VERB
gs-4426	316	15	to	to	PART
gs-4426	316	16	improve	improve	VERB
gs-4426	316	17	scalability	scalability	NOUN
gs-4426	316	18	,	,	PUNCT
gs-4426	316	19	reduce	reduce	VERB
gs-4426	316	20	costs	cost	NOUN
gs-4426	316	21	,	,	PUNCT
gs-4426	316	22	and	and	CCONJ
gs-4426	316	23	ensure	ensure	VERB
gs-4426	316	24	consistent	consistent	ADJ
gs-4426	316	25	product	product	NOUN
gs-4426	316	26	quality	quality	NOUN
gs-4426	316	27	.	.	PUNCT
gs-4426	317	1	decentralized	decentralize	VERB
gs-4426	317	2	or	or	CCONJ
gs-4426	317	3	pointof	pointof	NOUN
gs-4426	317	4	-	-	PUNCT
gs-4426	317	5	care	care	NOUN
gs-4426	317	6	manufacturing	manufacturing	NOUN
gs-4426	317	7	models	model	NOUN
gs-4426	317	8	,	,	PUNCT
gs-4426	317	9	where	where	SCONJ
gs-4426	317	10	feasible	feasible	ADJ
gs-4426	317	11	,	,	PUNCT
gs-4426	317	12	may	may	AUX
gs-4426	317	13	significantly	significantly	ADV
gs-4426	317	14	shorten	shorten	VERB
gs-4426	317	15	treatment	treatment	NOUN
gs-4426	317	16	timelines	timeline	NOUN
gs-4426	317	17	and	and	CCONJ
gs-4426	317	18	improve	improve	VERB
gs-4426	317	19	access	access	NOUN
gs-4426	317	20	,	,	PUNCT
gs-4426	317	21	particularly	particularly	ADV
gs-4426	317	22	for	for	ADP
gs-4426	317	23	autologous	autologous	ADJ
gs-4426	317	24	cell	cell	NOUN
gs-4426	317	25	therapies	therapy	NOUN
gs-4426	317	26	.	.	PUNCT
gs-4426	318	1	standardization	standardization	NOUN
gs-4426	318	2	of	of	ADP
gs-4426	318	3	analytical	analytical	ADJ
gs-4426	318	4	assays	assay	NOUN
gs-4426	318	5	and	and	CCONJ
gs-4426	318	6	potency	potency	NOUN
gs-4426	318	7	metrics	metric	NOUN
gs-4426	318	8	across	across	ADP
gs-4426	318	9	platforms	platform	NOUN
gs-4426	318	10	will	will	AUX
gs-4426	318	11	further	far	ADV
gs-4426	318	12	enhance	enhance	VERB
gs-4426	318	13	regulatory	regulatory	ADJ
gs-4426	318	14	confidence	confidence	NOUN
gs-4426	318	15	and	and	CCONJ
gs-4426	318	16	facilitate	facilitate	VERB
gs-4426	318	17	global	global	ADJ
gs-4426	318	18	harmonization	harmonization	NOUN
gs-4426	318	19	.	.	PUNCT
gs-4426	319	1	long	long	ADJ
gs-4426	319	2	-	-	PUNCT
gs-4426	319	3	term	term	NOUN
gs-4426	319	4	safety	safety	NOUN
gs-4426	319	5	and	and	CCONJ
gs-4426	319	6	effectiveness	effectiveness	NOUN
gs-4426	319	7	monitoring	monitoring	NOUN
gs-4426	319	8	should	should	AUX
gs-4426	319	9	remain	remain	VERB
gs-4426	319	10	a	a	DET
gs-4426	319	11	core	core	NOUN
gs-4426	319	12	component	component	NOUN
gs-4426	319	13	of	of	ADP
gs-4426	319	14	gene	gene	NOUN
gs-4426	319	15	therapy	therapy	NOUN
gs-4426	319	16	deployment	deployment	NOUN
gs-4426	319	17	.	.	PUNCT
gs-4426	320	1	robust	robust	ADJ
gs-4426	320	2	post	post	ADJ
gs-4426	320	3	-	-	ADJ
gs-4426	320	4	marketing	marketing	ADJ
gs-4426	320	5	surveillance	surveillance	NOUN
gs-4426	320	6	systems	system	NOUN
gs-4426	320	7	,	,	PUNCT
gs-4426	320	8	international	international	ADJ
gs-4426	320	9	patient	patient	NOUN
gs-4426	320	10	registries	registry	NOUN
gs-4426	320	11	,	,	PUNCT
gs-4426	320	12	and	and	CCONJ
gs-4426	320	13	real	real	ADJ
gs-4426	320	14	-	-	PUNCT
gs-4426	320	15	world	world	NOUN
gs-4426	320	16	evidence	evidence	NOUN
gs-4426	320	17	generation	generation	NOUN
gs-4426	320	18	are	be	AUX
gs-4426	320	19	necessary	necessary	ADJ
gs-4426	320	20	to	to	PART
gs-4426	320	21	detect	detect	VERB
gs-4426	320	22	lateemerging	lateemerge	VERB
gs-4426	320	23	adverse	adverse	ADJ
gs-4426	320	24	events	event	NOUN
gs-4426	320	25	,	,	PUNCT
gs-4426	320	26	assess	assess	VERB
gs-4426	320	27	durability	durability	NOUN
gs-4426	320	28	of	of	ADP
gs-4426	320	29	therapeutic	therapeutic	ADJ
gs-4426	320	30	benefit	benefit	NOUN
gs-4426	320	31	,	,	PUNCT
gs-4426	320	32	and	and	CCONJ
gs-4426	320	33	refine	refine	VERB
gs-4426	320	34	patient	patient	ADJ
gs-4426	320	35	selection	selection	NOUN
gs-4426	320	36	criteria	criterion	NOUN
gs-4426	320	37	.	.	PUNCT
gs-4426	321	1	integration	integration	NOUN
gs-4426	321	2	of	of	ADP
gs-4426	321	3	digital	digital	ADJ
gs-4426	321	4	health	health	NOUN
gs-4426	321	5	technologies	technology	NOUN
gs-4426	321	6	and	and	CCONJ
gs-4426	321	7	biomarker	biomarker	NOUN
gs-4426	321	8	-	-	PUNCT
gs-4426	321	9	driven	drive	VERB
gs-4426	321	10	monitoring	monitoring	NOUN
gs-4426	321	11	may	may	AUX
gs-4426	321	12	reduce	reduce	VERB
gs-4426	321	13	patient	patient	ADJ
gs-4426	321	14	burden	burden	NOUN
gs-4426	321	15	while	while	SCONJ
gs-4426	321	16	improving	improve	VERB
gs-4426	321	17	data	datum	NOUN
gs-4426	321	18	quality	quality	NOUN
gs-4426	321	19	and	and	CCONJ
gs-4426	321	20	completeness	completeness	NOUN
gs-4426	321	21	over	over	ADP
gs-4426	321	22	extended	extended	ADJ
gs-4426	321	23	follow	follow	NOUN
gs-4426	321	24	-	-	PUNCT
gs-4426	321	25	up	up	ADP
gs-4426	321	26	periods	period	NOUN
gs-4426	321	27	.	.	PUNCT
gs-4426	322	1	sustainable	sustainable	ADJ
gs-4426	322	2	economic	economic	ADJ
gs-4426	322	3	and	and	CCONJ
gs-4426	322	4	reimbursement	reimbursement	NOUN
gs-4426	322	5	frameworks	framework	NOUN
gs-4426	322	6	must	must	AUX
gs-4426	322	7	be	be	AUX
gs-4426	322	8	developed	develop	VERB
gs-4426	322	9	to	to	PART
gs-4426	322	10	align	align	VERB
gs-4426	322	11	innovation	innovation	NOUN
gs-4426	322	12	with	with	ADP
gs-4426	322	13	affordability	affordability	NOUN
gs-4426	322	14	.	.	PUNCT
gs-4426	323	1	outcomes	outcome	NOUN
gs-4426	323	2	-	-	PUNCT
gs-4426	323	3	based	base	VERB
gs-4426	323	4	payment	payment	NOUN
gs-4426	323	5	models	model	NOUN
gs-4426	323	6	,	,	PUNCT
gs-4426	323	7	annuity	annuity	NOUN
gs-4426	323	8	-	-	PUNCT
gs-4426	323	9	style	style	NOUN
gs-4426	323	10	reimbursement	reimbursement	NOUN
gs-4426	323	11	,	,	PUNCT
gs-4426	323	12	and	and	CCONJ
gs-4426	323	13	risk	risk	NOUN
gs-4426	323	14	-	-	PUNCT
gs-4426	323	15	sharing	share	VERB
gs-4426	323	16	agreements	agreement	NOUN
gs-4426	323	17	between	between	ADP
gs-4426	323	18	manufacturers	manufacturer	NOUN
gs-4426	323	19	and	and	CCONJ
gs-4426	323	20	payers	payer	NOUN
gs-4426	323	21	should	should	AUX
gs-4426	323	22	be	be	AUX
gs-4426	323	23	expanded	expand	VERB
gs-4426	323	24	and	and	CCONJ
gs-4426	323	25	rigorously	rigorously	ADV
gs-4426	323	26	evaluated	evaluate	VERB
gs-4426	323	27	.	.	PUNCT
gs-4426	324	1	public	public	ADJ
gs-4426	324	2	-	-	PUNCT
gs-4426	324	3	private	private	ADJ
gs-4426	324	4	partnerships	partnership	NOUN
gs-4426	324	5	and	and	CCONJ
gs-4426	324	6	international	international	ADJ
gs-4426	324	7	funding	funding	NOUN
gs-4426	324	8	mechanisms	mechanism	NOUN
gs-4426	324	9	may	may	AUX
gs-4426	324	10	play	play	VERB
gs-4426	324	11	a	a	DET
gs-4426	324	12	critical	critical	ADJ
gs-4426	324	13	role	role	NOUN
gs-4426	324	14	in	in	ADP
gs-4426	324	15	supporting	support	VERB
gs-4426	324	16	access	access	NOUN
gs-4426	324	17	to	to	ADP
gs-4426	324	18	gene	gene	NOUN
gs-4426	324	19	therapies	therapy	NOUN
gs-4426	324	20	in	in	ADP
gs-4426	324	21	lowand	lowand	ADJ
gs-4426	324	22	middle	middle	ADJ
gs-4426	324	23	-	-	PUNCT
gs-4426	324	24	income	income	NOUN
gs-4426	324	25	countries	country	NOUN
gs-4426	324	26	,	,	PUNCT
gs-4426	324	27	preventing	prevent	VERB
gs-4426	324	28	the	the	DET
gs-4426	324	29	emergence	emergence	NOUN
gs-4426	324	30	of	of	ADP
gs-4426	324	31	a	a	DET
gs-4426	324	32	global	global	ADJ
gs-4426	324	33	therapeutic	therapeutic	ADJ
gs-4426	324	34	divide	divide	NOUN
gs-4426	324	35	.	.	PUNCT
gs-4426	325	1	regulatory	regulatory	ADJ
gs-4426	325	2	agencies	agency	NOUN
gs-4426	325	3	should	should	AUX
gs-4426	325	4	continue	continue	VERB
gs-4426	325	5	to	to	PART
gs-4426	325	6	evolve	evolve	VERB
gs-4426	325	7	adaptive	adaptive	ADJ
gs-4426	325	8	,	,	PUNCT
gs-4426	325	9	science	science	NOUN
gs-4426	325	10	-	-	PUNCT
gs-4426	325	11	based	base	VERB
gs-4426	325	12	frameworks	framework	NOUN
gs-4426	325	13	that	that	PRON
gs-4426	325	14	accommodate	accommodate	VERB
gs-4426	325	15	platform	platform	NOUN
gs-4426	325	16	technologies	technology	NOUN
gs-4426	325	17	,	,	PUNCT
gs-4426	325	18	personalized	personalized	ADJ
gs-4426	325	19	therapies	therapy	NOUN
gs-4426	325	20	,	,	PUNCT
gs-4426	325	21	and	and	CCONJ
gs-4426	325	22	rapid	rapid	ADJ
gs-4426	325	23	iteration	iteration	NOUN
gs-4426	325	24	while	while	SCONJ
gs-4426	325	25	georgian	georgian	PROPN
gs-4426	325	26	scientists/	scientists/	NUM
gs-4426	325	27	.	.	PUNCT
gs-4426	326	1	7	7	NUM
gs-4426	326	2	n	n	DET
gs-4426	326	3	4	4	NUM
gs-4426	326	4	,	,	PUNCT
gs-4426	326	5	2025	2025	NUM
gs-4426	326	6	617	617	NUM
gs-4426	326	7	maintaining	maintain	VERB
gs-4426	326	8	rigorous	rigorous	ADJ
gs-4426	326	9	safety	safety	NOUN
gs-4426	326	10	standards	standard	NOUN
gs-4426	326	11	.	.	PUNCT
gs-4426	327	1	early	early	ADJ
gs-4426	327	2	and	and	CCONJ
gs-4426	327	3	continuous	continuous	ADJ
gs-4426	327	4	dialogue	dialogue	NOUN
gs-4426	327	5	between	between	ADP
gs-4426	327	6	developers	developer	NOUN
gs-4426	327	7	,	,	PUNCT
gs-4426	327	8	regulators	regulator	NOUN
gs-4426	327	9	,	,	PUNCT
gs-4426	327	10	clinicians	clinician	NOUN
gs-4426	327	11	,	,	PUNCT
gs-4426	327	12	and	and	CCONJ
gs-4426	327	13	patient	patient	ADJ
gs-4426	327	14	representatives	representative	NOUN
gs-4426	327	15	can	can	AUX
gs-4426	327	16	streamline	streamline	VERB
gs-4426	327	17	development	development	NOUN
gs-4426	327	18	pathways	pathway	NOUN
gs-4426	327	19	and	and	CCONJ
gs-4426	327	20	ensure	ensure	VERB
gs-4426	327	21	that	that	SCONJ
gs-4426	327	22	regulatory	regulatory	ADJ
gs-4426	327	23	decisions	decision	NOUN
gs-4426	327	24	reflect	reflect	VERB
gs-4426	327	25	both	both	DET
gs-4426	327	26	scientific	scientific	ADJ
gs-4426	327	27	evidence	evidence	NOUN
gs-4426	327	28	and	and	CCONJ
gs-4426	327	29	patient	patient	ADJ
gs-4426	327	30	priorities	priority	NOUN
gs-4426	327	31	.	.	PUNCT
gs-4426	328	1	interdisciplinary	interdisciplinary	ADJ
gs-4426	328	2	education	education	NOUN
gs-4426	328	3	and	and	CCONJ
gs-4426	328	4	workforce	workforce	PROPN
gs-4426	328	5	development	development	NOUN
gs-4426	328	6	are	be	AUX
gs-4426	328	7	imperative	imperative	ADJ
gs-4426	328	8	.	.	PUNCT
gs-4426	329	1	clinicians	clinician	NOUN
gs-4426	329	2	,	,	PUNCT
gs-4426	329	3	pharmacists	pharmacist	NOUN
gs-4426	329	4	,	,	PUNCT
gs-4426	329	5	genetic	genetic	ADJ
gs-4426	329	6	counselors	counselor	NOUN
gs-4426	329	7	,	,	PUNCT
gs-4426	329	8	and	and	CCONJ
gs-4426	329	9	allied	ally	VERB
gs-4426	329	10	healthcare	healthcare	NOUN
gs-4426	329	11	professionals	professional	NOUN
gs-4426	329	12	must	must	AUX
gs-4426	329	13	be	be	AUX
gs-4426	329	14	adequately	adequately	ADV
gs-4426	329	15	trained	train	VERB
gs-4426	329	16	in	in	ADP
gs-4426	329	17	gene	gene	NOUN
gs-4426	329	18	therapy	therapy	NOUN
gs-4426	329	19	mechanisms	mechanism	NOUN
gs-4426	329	20	,	,	PUNCT
gs-4426	329	21	administration	administration	NOUN
gs-4426	329	22	,	,	PUNCT
gs-4426	329	23	toxicity	toxicity	NOUN
gs-4426	329	24	management	management	NOUN
gs-4426	329	25	,	,	PUNCT
gs-4426	329	26	and	and	CCONJ
gs-4426	329	27	ethical	ethical	ADJ
gs-4426	329	28	considerations	consideration	NOUN
gs-4426	329	29	.	.	PUNCT
gs-4426	330	1	public	public	ADJ
gs-4426	330	2	engagement	engagement	NOUN
gs-4426	330	3	and	and	CCONJ
gs-4426	330	4	transparent	transparent	ADJ
gs-4426	330	5	communication	communication	NOUN
gs-4426	330	6	are	be	AUX
gs-4426	330	7	equally	equally	ADV
gs-4426	330	8	important	important	ADJ
gs-4426	330	9	to	to	PART
gs-4426	330	10	foster	foster	VERB
gs-4426	330	11	informed	informed	ADJ
gs-4426	330	12	consent	consent	NOUN
gs-4426	330	13	,	,	PUNCT
gs-4426	330	14	manage	manage	VERB
gs-4426	330	15	expectations	expectation	NOUN
gs-4426	330	16	,	,	PUNCT
gs-4426	330	17	and	and	CCONJ
gs-4426	330	18	build	build	VERB
gs-4426	330	19	societal	societal	ADJ
gs-4426	330	20	trust	trust	NOUN
gs-4426	330	21	in	in	ADP
gs-4426	330	22	genetic	genetic	ADJ
gs-4426	330	23	medicines	medicine	NOUN
gs-4426	330	24	.	.	PUNCT
gs-4426	331	1	the	the	DET
gs-4426	331	2	recommendations	recommendation	NOUN
gs-4426	331	3	emphasize	emphasize	VERB
gs-4426	331	4	that	that	SCONJ
gs-4426	331	5	the	the	DET
gs-4426	331	6	future	future	ADJ
gs-4426	331	7	success	success	NOUN
gs-4426	331	8	of	of	ADP
gs-4426	331	9	gene	gene	NOUN
gs-4426	331	10	therapy	therapy	NOUN
gs-4426	331	11	will	will	AUX
gs-4426	331	12	depend	depend	VERB
gs-4426	331	13	not	not	PART
gs-4426	331	14	only	only	ADV
gs-4426	331	15	on	on	ADP
gs-4426	331	16	scientific	scientific	ADJ
gs-4426	331	17	breakthroughs	breakthrough	NOUN
gs-4426	331	18	but	but	CCONJ
gs-4426	331	19	also	also	ADV
gs-4426	331	20	on	on	ADP
gs-4426	331	21	coordinated	coordinated	ADJ
gs-4426	331	22	systemic	systemic	ADJ
gs-4426	331	23	action	action	NOUN
gs-4426	331	24	.	.	PUNCT
gs-4426	332	1	by	by	ADP
gs-4426	332	2	addressing	address	VERB
gs-4426	332	3	technological	technological	ADJ
gs-4426	332	4	,	,	PUNCT
gs-4426	332	5	economic	economic	ADJ
gs-4426	332	6	,	,	PUNCT
gs-4426	332	7	regulatory	regulatory	ADJ
gs-4426	332	8	,	,	PUNCT
gs-4426	332	9	and	and	CCONJ
gs-4426	332	10	ethical	ethical	ADJ
gs-4426	332	11	dimensions	dimension	NOUN
gs-4426	332	12	in	in	ADP
gs-4426	332	13	parallel	parallel	NOUN
gs-4426	332	14	,	,	PUNCT
gs-4426	332	15	the	the	DET
gs-4426	332	16	gene	gene	NOUN
gs-4426	332	17	therapy	therapy	NOUN
gs-4426	332	18	field	field	NOUN
gs-4426	332	19	can	can	AUX
gs-4426	332	20	progress	progress	VERB
gs-4426	332	21	toward	toward	ADP
gs-4426	332	22	its	its	PRON
gs-4426	332	23	ultimate	ultimate	ADJ
gs-4426	332	24	objective	objective	NOUN
gs-4426	332	25	:	:	PUNCT
gs-4426	332	26	delivering	deliver	VERB
gs-4426	332	27	safe	safe	ADJ
gs-4426	332	28	,	,	PUNCT
gs-4426	332	29	durable	durable	ADJ
gs-4426	332	30	,	,	PUNCT
gs-4426	332	31	and	and	CCONJ
gs-4426	332	32	accessible	accessible	ADJ
gs-4426	332	33	genetic	genetic	ADJ
gs-4426	332	34	treatments	treatment	NOUN
gs-4426	332	35	that	that	PRON
gs-4426	332	36	meaningfully	meaningfully	ADV
gs-4426	332	37	improve	improve	VERB
gs-4426	332	38	patient	patient	ADJ
gs-4426	332	39	outcomes	outcome	NOUN
gs-4426	332	40	on	on	ADP
gs-4426	332	41	a	a	DET
gs-4426	332	42	global	global	ADJ
gs-4426	332	43	scale	scale	NOUN
gs-4426	332	44	.	.	PUNCT
gs-4426	333	1	references	reference	NOUN
gs-4426	333	2	1	1	NUM
gs-4426	333	3	.	.	PUNCT
gs-4426	334	1	cotrim	cotrim	PROPN
gs-4426	334	2	,	,	PUNCT
gs-4426	334	3	a.	a.	NOUN
gs-4426	334	4	p.	p.	PROPN
gs-4426	334	5	,	,	PUNCT
gs-4426	334	6	&	&	CCONJ
gs-4426	334	7	baum	baum	PROPN
gs-4426	334	8	,	,	PUNCT
gs-4426	334	9	b.	b.	PROPN
gs-4426	334	10	j.	j.	PROPN
gs-4426	334	11	(	(	PUNCT
gs-4426	334	12	2008	2008	NUM
gs-4426	334	13	)	)	PUNCT
gs-4426	334	14	.	.	PUNCT
gs-4426	335	1	gene	gene	NOUN
gs-4426	335	2	therapy	therapy	NOUN
gs-4426	335	3	:	:	PUNCT
gs-4426	335	4	some	some	DET
gs-4426	335	5	history	history	NOUN
gs-4426	335	6	,	,	PUNCT
gs-4426	335	7	applications	application	NOUN
gs-4426	335	8	,	,	PUNCT
gs-4426	335	9	problems	problem	NOUN
gs-4426	335	10	,	,	PUNCT
gs-4426	335	11	and	and	CCONJ
gs-4426	335	12	prospects	prospect	NOUN
gs-4426	335	13	.	.	PUNCT
gs-4426	336	1	toxicologic	toxicologic	ADJ
gs-4426	336	2	pathology	pathology	NOUN
gs-4426	336	3	,	,	PUNCT
gs-4426	336	4	36(1	36(1	NUM
gs-4426	336	5	)	)	PUNCT
gs-4426	336	6	,	,	PUNCT
gs-4426	336	7	97	97	NUM
gs-4426	336	8	-	-	SYM
gs-4426	336	9	103	103	NUM
gs-4426	336	10	.	.	NOUN
gs-4426	337	1	2	2	NUM
gs-4426	337	2	.	.	X
gs-4426	337	3	davies	davy	NOUN
gs-4426	337	4	,	,	PUNCT
gs-4426	337	5	b.	b.	PROPN
gs-4426	337	6	,	,	PUNCT
gs-4426	337	7	zhan	zhan	PROPN
gs-4426	337	8	,	,	PUNCT
gs-4426	337	9	h.	h.	PROPN
gs-4426	337	10	,	,	PUNCT
gs-4426	337	11	&	&	CCONJ
gs-4426	337	12	atkins	atkins	PROPN
gs-4426	337	13	,	,	PUNCT
gs-4426	337	14	h.	h.	PROPN
gs-4426	337	15	(	(	PUNCT
gs-4426	337	16	2024	2024	NUM
gs-4426	337	17	)	)	PUNCT
gs-4426	337	18	.	.	PUNCT
gs-4426	338	1	crispr	crispr	ADJ
gs-4426	338	2	gene	gene	NOUN
gs-4426	338	3	editing	edit	VERB
gs-4426	338	4	in	in	ADP
gs-4426	338	5	clinical	clinical	ADJ
gs-4426	338	6	trials	trial	NOUN
gs-4426	338	7	:	:	PUNCT
gs-4426	338	8	current	current	ADJ
gs-4426	338	9	state	state	NOUN
gs-4426	338	10	and	and	CCONJ
gs-4426	338	11	future	future	ADJ
gs-4426	338	12	prospects	prospect	NOUN
gs-4426	338	13	.	.	PUNCT
gs-4426	339	1	nature	nature	NOUN
gs-4426	339	2	medicine	medicine	NOUN
gs-4426	339	3	,	,	PUNCT
gs-4426	339	4	30(4	30(4	NUM
gs-4426	339	5	)	)	PUNCT
gs-4426	339	6	,	,	PUNCT
gs-4426	339	7	891	891	NUM
gs-4426	339	8	-	-	SYM
gs-4426	339	9	903	903	NUM
gs-4426	339	10	.	.	PUNCT
gs-4426	340	1	3	3	X
gs-4426	340	2	.	.	X
gs-4426	340	3	ginn	ginn	PROPN
gs-4426	340	4	,	,	PUNCT
gs-4426	340	5	s.	s.	PROPN
gs-4426	340	6	l.	l.	PROPN
gs-4426	340	7	,	,	PUNCT
gs-4426	340	8	amaya	amaya	PROPN
gs-4426	340	9	,	,	PUNCT
gs-4426	340	10	a.	a.	PROPN
gs-4426	340	11	k.	k.	PROPN
gs-4426	340	12	,	,	PUNCT
gs-4426	340	13	alexander	alexander	PROPN
gs-4426	340	14	,	,	PUNCT
gs-4426	340	15	i.	i.	PROPN
gs-4426	340	16	e.	e.	PROPN
gs-4426	340	17	,	,	PUNCT
gs-4426	340	18	edelstein	edelstein	PROPN
gs-4426	340	19	,	,	PUNCT
gs-4426	340	20	m.	m.	NOUN
gs-4426	340	21	,	,	PUNCT
gs-4426	340	22	&	&	CCONJ
gs-4426	340	23	abedi	abedi	PROPN
gs-4426	340	24	,	,	PUNCT
gs-4426	340	25	m.	m.	PROPN
gs-4426	340	26	r.	r.	PROPN
gs-4426	340	27	(	(	PUNCT
gs-4426	340	28	2024	2024	NUM
gs-4426	340	29	)	)	PUNCT
gs-4426	340	30	.	.	PUNCT
gs-4426	341	1	gene	gene	NOUN
gs-4426	341	2	therapy	therapy	NOUN
gs-4426	341	3	clinical	clinical	ADJ
gs-4426	341	4	trials	trial	NOUN
gs-4426	341	5	worldwide	worldwide	ADV
gs-4426	341	6	to	to	ADP
gs-4426	341	7	2024	2024	NUM
gs-4426	341	8	:	:	PUNCT
gs-4426	341	9	an	an	DET
gs-4426	341	10	update	update	NOUN
gs-4426	341	11	.	.	PUNCT
gs-4426	342	1	the	the	DET
gs-4426	342	2	journal	journal	NOUN
gs-4426	342	3	of	of	ADP
gs-4426	342	4	gene	gene	NOUN
gs-4426	342	5	medicine	medicine	NOUN
gs-4426	342	6	,	,	PUNCT
gs-4426	342	7	26(1	26(1	NUM
gs-4426	342	8	)	)	PUNCT
gs-4426	342	9	,	,	PUNCT
gs-4426	342	10	e3628	e3628	X
gs-4426	342	11	.	.	PUNCT
gs-4426	343	1	4	4	X
gs-4426	343	2	.	.	X
gs-4426	343	3	han	han	PROPN
gs-4426	343	4	,	,	PUNCT
gs-4426	343	5	d.	d.	PROPN
gs-4426	343	6	,	,	PUNCT
gs-4426	343	7	xu	xu	PROPN
gs-4426	343	8	,	,	PUNCT
gs-4426	343	9	z.	z.	PROPN
gs-4426	343	10	,	,	PUNCT
gs-4426	343	11	zhuang	zhuang	PROPN
gs-4426	343	12	,	,	PUNCT
gs-4426	343	13	y.	y.	PROPN
gs-4426	343	14	,	,	PUNCT
gs-4426	343	15	ye	ye	PROPN
gs-4426	343	16	,	,	PUNCT
gs-4426	343	17	z.	z.	PROPN
gs-4426	343	18	,	,	PUNCT
gs-4426	343	19	&	&	CCONJ
gs-4426	343	20	qian	qian	PROPN
gs-4426	343	21	,	,	PUNCT
gs-4426	343	22	q.	q.	PROPN
gs-4426	343	23	(	(	PUNCT
gs-4426	343	24	2021	2021	NUM
gs-4426	343	25	)	)	PUNCT
gs-4426	343	26	.	.	PUNCT
gs-4426	344	1	current	current	ADJ
gs-4426	344	2	progress	progress	NOUN
gs-4426	344	3	in	in	ADP
gs-4426	344	4	car	car	NOUN
gs-4426	344	5	-	-	PUNCT
gs-4426	344	6	t	t	NOUN
gs-4426	344	7	cell	cell	NOUN
gs-4426	344	8	therapy	therapy	NOUN
gs-4426	344	9	for	for	ADP
gs-4426	344	10	hematological	hematological	ADJ
gs-4426	344	11	malignancies	malignancy	NOUN
gs-4426	344	12	.	.	PUNCT
gs-4426	345	1	journal	journal	PROPN
gs-4426	345	2	of	of	ADP
gs-4426	345	3	cancer	cancer	NOUN
gs-4426	345	4	,	,	PUNCT
gs-4426	345	5	12(2	12(2	NUM
gs-4426	345	6	)	)	PUNCT
gs-4426	345	7	,	,	PUNCT
gs-4426	345	8	326	326	NUM
gs-4426	345	9	-	-	SYM
gs-4426	345	10	334	334	NUM
gs-4426	345	11	.	.	PUNCT
gs-4426	346	1	5	5	X
gs-4426	346	2	.	.	X
gs-4426	346	3	khan	khan	PROPN
gs-4426	346	4	,	,	PUNCT
gs-4426	346	5	m.	m.	NOUN
gs-4426	346	6	i.	i.	PROPN
gs-4426	346	7	,	,	PUNCT
gs-4426	346	8	rafiq	rafiq	PROPN
gs-4426	346	9	,	,	PUNCT
gs-4426	346	10	s.	s.	PROPN
gs-4426	346	11	,	,	PUNCT
gs-4426	346	12	&	&	CCONJ
gs-4426	346	13	khalid	khalid	PROPN
gs-4426	346	14	,	,	PUNCT
gs-4426	346	15	s.	s.	PROPN
gs-4426	346	16	(	(	PUNCT
gs-4426	346	17	2024	2024	NUM
gs-4426	346	18	)	)	PUNCT
gs-4426	346	19	.	.	PUNCT
gs-4426	347	1	expanding	expand	VERB
gs-4426	347	2	gene	gene	NOUN
gs-4426	347	3	therapy	therapy	NOUN
gs-4426	347	4	applications	application	NOUN
gs-4426	347	5	:	:	PUNCT
gs-4426	347	6	from	from	ADP
gs-4426	347	7	rare	rare	ADJ
gs-4426	347	8	diseases	disease	NOUN
gs-4426	347	9	to	to	ADP
gs-4426	347	10	common	common	ADJ
gs-4426	347	11	chronic	chronic	ADJ
gs-4426	347	12	conditions	condition	NOUN
gs-4426	347	13	.	.	PUNCT
gs-4426	348	1	molecular	molecular	ADJ
gs-4426	348	2	therapy	therapy	NOUN
gs-4426	348	3	,	,	PUNCT
gs-4426	348	4	32(5	32(5	NUM
gs-4426	348	5	)	)	PUNCT
gs-4426	348	6	,	,	PUNCT
gs-4426	348	7	1234	1234	NUM
gs-4426	348	8	-	-	SYM
gs-4426	348	9	1248	1248	NUM
gs-4426	348	10	.	.	PUNCT
gs-4426	349	1	6	6	NUM
gs-4426	349	2	.	.	X
gs-4426	349	3	kumar	kumar	PROPN
gs-4426	349	4	,	,	PUNCT
gs-4426	349	5	s.	s.	PROPN
gs-4426	349	6	r.	r.	PROPN
gs-4426	349	7	,	,	PUNCT
gs-4426	349	8	markusic	markusic	NOUN
gs-4426	349	9	,	,	PUNCT
gs-4426	349	10	d.	d.	PROPN
gs-4426	349	11	m.	m.	PROPN
gs-4426	349	12	,	,	PUNCT
gs-4426	349	13	biswas	biswas	PROPN
gs-4426	349	14	,	,	PUNCT
gs-4426	349	15	m.	m.	NOUN
gs-4426	349	16	,	,	PUNCT
gs-4426	349	17	high	high	ADJ
gs-4426	349	18	,	,	PUNCT
gs-4426	349	19	k.	k.	PROPN
gs-4426	349	20	a.	a.	PROPN
gs-4426	349	21	,	,	PUNCT
gs-4426	349	22	&	&	CCONJ
gs-4426	349	23	herzog	herzog	PROPN
gs-4426	349	24	,	,	PUNCT
gs-4426	349	25	r.	r.	PROPN
gs-4426	349	26	w.	w.	PROPN
gs-4426	349	27	(	(	PUNCT
gs-4426	349	28	2016	2016	NUM
gs-4426	349	29	)	)	PUNCT
gs-4426	349	30	.	.	PUNCT
gs-4426	350	1	clinical	clinical	ADJ
gs-4426	350	2	development	development	NOUN
gs-4426	350	3	of	of	ADP
gs-4426	350	4	gene	gene	NOUN
gs-4426	350	5	therapy	therapy	NOUN
gs-4426	350	6	:	:	PUNCT
gs-4426	350	7	results	result	NOUN
gs-4426	350	8	and	and	CCONJ
gs-4426	350	9	lessons	lesson	NOUN
gs-4426	350	10	from	from	ADP
gs-4426	350	11	recent	recent	ADJ
gs-4426	350	12	successes	success	NOUN
gs-4426	350	13	.	.	PUNCT
gs-4426	351	1	molecular	molecular	ADJ
gs-4426	351	2	therapy	therapy	NOUN
gs-4426	351	3	methods	method	NOUN
gs-4426	351	4	&	&	CCONJ
gs-4426	351	5	clinical	clinical	ADJ
gs-4426	351	6	development	development	NOUN
gs-4426	351	7	,	,	PUNCT
gs-4426	351	8	3	3	NUM
gs-4426	351	9	,	,	PUNCT
gs-4426	351	10	16034	16034	NUM
gs-4426	351	11	.	.	PUNCT
gs-4426	352	1	7	7	X
gs-4426	352	2	.	.	X
gs-4426	352	3	sulashvili	sulashvili	NOUN
gs-4426	352	4	,	,	PUNCT
gs-4426	352	5	n.	n.	NOUN
gs-4426	352	6	,	,	PUNCT
gs-4426	352	7	davitashvili	davitashvili	ADJ
gs-4426	352	8	,	,	PUNCT
gs-4426	352	9	m.	m.	NOUN
gs-4426	352	10	,	,	PUNCT
gs-4426	352	11	gorgaslidze	gorgaslidze	PROPN
gs-4426	352	12	,	,	PUNCT
gs-4426	352	13	n.	n.	NOUN
gs-4426	352	14	,	,	PUNCT
gs-4426	352	15	gabunia	gabunia	NOUN
gs-4426	352	16	,	,	PUNCT
gs-4426	352	17	l.	l.	PROPN
gs-4426	352	18	,	,	PUNCT
gs-4426	352	19	beglaryan	beglaryan	ADJ
gs-4426	352	20	,	,	PUNCT
gs-4426	352	21	m.	m.	NOUN
gs-4426	352	22	,	,	PUNCT
gs-4426	352	23	alavidze	alavidze	NOUN
gs-4426	352	24	,	,	PUNCT
gs-4426	352	25	n.	n.	NOUN
gs-4426	352	26	,	,	PUNCT
gs-4426	352	27	sulashvili	sulashvili	NOUN
gs-4426	352	28	,	,	PUNCT
gs-4426	352	29	m.	m.	NOUN
gs-4426	352	30	(	(	PUNCT
gs-4426	352	31	2024	2024	NUM
gs-4426	352	32	)	)	PUNCT
gs-4426	352	33	.	.	PUNCT
gs-4426	353	1	the	the	DET
gs-4426	353	2	scientific	scientific	ADJ
gs-4426	353	3	discussion	discussion	NOUN
gs-4426	353	4	of	of	ADP
gs-4426	353	5	some	some	DET
gs-4426	353	6	issues	issue	NOUN
gs-4426	353	7	of	of	ADP
gs-4426	353	8	features	feature	NOUN
gs-4426	353	9	and	and	CCONJ
gs-4426	353	10	challenges	challenge	NOUN
gs-4426	353	11	of	of	ADP
gs-4426	353	12	using	use	VERB
gs-4426	353	13	of	of	ADP
gs-4426	353	14	car	car	NOUN
gs-4426	353	15	-	-	PUNCT
gs-4426	353	16	t	t	NOUN
gs-4426	353	17	cells	cell	NOUN
gs-4426	353	18	in	in	ADP
gs-4426	353	19	immunotherapy	immunotherapy	NOUN
gs-4426	353	20	.	.	PUNCT
gs-4426	354	1	georgian	georgian	ADJ
gs-4426	354	2	scientists	scientist	NOUN
gs-4426	354	3	,	,	PUNCT
gs-4426	354	4	6(4	6(4	NOUN
gs-4426	354	5	)	)	PUNCT
gs-4426	354	6	,	,	PUNCT
gs-4426	354	7	263–290	263–290	NUM
gs-4426	354	8	.	.	PUNCT
gs-4426	354	9	https://doi.org/10.52340/gs.2024.06.04.24	https://doi.org/10.52340/gs.2024.06.04.24	PROPN
gs-4426	354	10	8	8	NUM
gs-4426	354	11	.	.	PUNCT
gs-4426	355	1	lapteva	lapteva	PROPN
gs-4426	355	2	,	,	PUNCT
gs-4426	355	3	l.	l.	PROPN
gs-4426	355	4	,	,	PUNCT
gs-4426	355	5	purohit	purohit	PROPN
gs-4426	355	6	-	-	PUNCT
gs-4426	355	7	sheth	sheth	PROPN
gs-4426	355	8	,	,	PUNCT
gs-4426	355	9	t.	t.	PROPN
gs-4426	355	10	,	,	PUNCT
gs-4426	355	11	serabian	serabian	ADJ
gs-4426	355	12	,	,	PUNCT
gs-4426	355	13	m.	m.	NOUN
gs-4426	355	14	,	,	PUNCT
gs-4426	355	15	&	&	CCONJ
gs-4426	355	16	puri	puri	PROPN
gs-4426	355	17	,	,	PUNCT
gs-4426	355	18	r.	r.	PROPN
gs-4426	355	19	k.	k.	PROPN
gs-4426	355	20	(	(	PUNCT
gs-4426	355	21	2020	2020	NUM
gs-4426	355	22	)	)	PUNCT
gs-4426	355	23	.	.	PUNCT
gs-4426	356	1	clinical	clinical	ADJ
gs-4426	356	2	development	development	NOUN
gs-4426	356	3	and	and	CCONJ
gs-4426	356	4	regulation	regulation	NOUN
gs-4426	356	5	of	of	ADP
gs-4426	356	6	cell	cell	NOUN
gs-4426	356	7	and	and	CCONJ
gs-4426	356	8	gene	gene	NOUN
gs-4426	356	9	therapies	therapy	NOUN
gs-4426	356	10	.	.	PUNCT
gs-4426	357	1	cytotherapy	cytotherapy	NOUN
gs-4426	357	2	,	,	PUNCT
gs-4426	357	3	22(10	22(10	NUM
gs-4426	357	4	)	)	PUNCT
gs-4426	357	5	,	,	PUNCT
gs-4426	357	6	594	594	NUM
gs-4426	357	7	-	-	SYM
gs-4426	357	8	602	602	NUM
gs-4426	357	9	.	.	PUNCT
gs-4426	358	1	9	9	X
gs-4426	358	2	.	.	X
gs-4426	358	3	leonard	leonard	PROPN
gs-4426	358	4	,	,	PUNCT
gs-4426	358	5	a.	a.	PROPN
gs-4426	358	6	,	,	PUNCT
gs-4426	358	7	&	&	CCONJ
gs-4426	358	8	tisdale	tisdale	PROPN
gs-4426	358	9	,	,	PUNCT
gs-4426	358	10	j.	j.	PROPN
gs-4426	358	11	f.	f.	PROPN
gs-4426	358	12	(	(	PUNCT
gs-4426	358	13	2024	2024	NUM
gs-4426	358	14	)	)	PUNCT
gs-4426	358	15	.	.	PUNCT
gs-4426	359	1	crispr	crispr	NOUN
gs-4426	359	2	-	-	PUNCT
gs-4426	359	3	edited	edit	VERB
gs-4426	359	4	hematopoietic	hematopoietic	ADJ
gs-4426	359	5	stem	stem	NOUN
gs-4426	359	6	cells	cell	NOUN
gs-4426	359	7	for	for	ADP
gs-4426	359	8	sickle	sickle	NOUN
gs-4426	359	9	cell	cell	NOUN
gs-4426	359	10	disease	disease	NOUN
gs-4426	359	11	and	and	CCONJ
gs-4426	359	12	-thalassemia	-thalassemia	NOUN
gs-4426	359	13	.	.	PUNCT
gs-4426	360	1	new	new	PROPN
gs-4426	360	2	england	england	PROPN
gs-4426	360	3	journal	journal	PROPN
gs-4426	360	4	of	of	ADP
gs-4426	360	5	medicine	medicine	NOUN
gs-4426	360	6	,	,	PUNCT
gs-4426	360	7	390(3	390(3	NUM
gs-4426	360	8	)	)	PUNCT
gs-4426	360	9	,	,	PUNCT
gs-4426	360	10	282	282	NUM
gs-4426	360	11	-	-	SYM
gs-4426	360	12	295	295	NUM
gs-4426	360	13	.	.	PUNCT
gs-4426	361	1	10	10	NUM
gs-4426	361	2	.	.	X
gs-4426	362	1	lu	lu	PROPN
gs-4426	362	2	,	,	PUNCT
gs-4426	362	3	y.	y.	PROPN
gs-4426	362	4	,	,	PUNCT
gs-4426	362	5	&	&	CCONJ
gs-4426	362	6	jiang	jiang	PROPN
gs-4426	362	7	,	,	PUNCT
gs-4426	362	8	p.	p.	NOUN
gs-4426	362	9	(	(	PUNCT
gs-4426	362	10	2022	2022	NUM
gs-4426	362	11	)	)	PUNCT
gs-4426	362	12	.	.	PUNCT
gs-4426	363	1	lentiviral	lentiviral	ADJ
gs-4426	363	2	vectors	vector	NOUN
gs-4426	363	3	in	in	ADP
gs-4426	363	4	gene	gene	NOUN
gs-4426	363	5	therapy	therapy	NOUN
gs-4426	363	6	:	:	PUNCT
gs-4426	363	7	current	current	ADJ
gs-4426	363	8	applications	application	NOUN
gs-4426	363	9	and	and	CCONJ
gs-4426	363	10	future	future	ADJ
gs-4426	363	11	perspectives	perspective	NOUN
gs-4426	363	12	.	.	PUNCT
gs-4426	364	1	molecular	molecular	ADJ
gs-4426	364	2	therapy	therapy	NOUN
gs-4426	364	3	nucleic	nucleic	ADJ
gs-4426	364	4	acids	acid	NOUN
gs-4426	364	5	,	,	PUNCT
gs-4426	364	6	28	28	NUM
gs-4426	364	7	,	,	PUNCT
gs-4426	364	8	734	734	NUM
gs-4426	364	9	-	-	SYM
gs-4426	364	10	748	748	NUM
gs-4426	364	11	.	.	PUNCT
gs-4426	365	1	georgian	georgian	NOUN
gs-4426	365	2	scientists/	scientists/	NUM
gs-4426	365	3	.	.	PUNCT
gs-4426	366	1	7	7	NUM
gs-4426	366	2	n	n	DET
gs-4426	366	3	4	4	NUM
gs-4426	366	4	,	,	PUNCT
gs-4426	366	5	2025	2025	NUM
gs-4426	366	6	618	618	NUM
gs-4426	366	7	11	11	NUM
gs-4426	366	8	.	.	PUNCT
gs-4426	367	1	rahmat	rahmat	NOUN
gs-4426	367	2	,	,	PUNCT
gs-4426	367	3	f.	f.	PROPN
gs-4426	367	4	,	,	PUNCT
gs-4426	367	5	joudeh	joudeh	NOUN
gs-4426	367	6	,	,	PUNCT
gs-4426	367	7	n.	n.	NOUN
gs-4426	367	8	,	,	PUNCT
gs-4426	367	9	&	&	CCONJ
gs-4426	367	10	alshraideh	alshraideh	PROPN
gs-4426	367	11	,	,	PUNCT
gs-4426	367	12	h.	h.	PROPN
gs-4426	367	13	(	(	PUNCT
gs-4426	367	14	2024	2024	NUM
gs-4426	367	15	)	)	PUNCT
gs-4426	367	16	.	.	PUNCT
gs-4426	368	1	gene	gene	NOUN
gs-4426	368	2	therapy	therapy	NOUN
gs-4426	368	3	approaches	approach	VERB
gs-4426	368	4	for	for	ADP
gs-4426	368	5	sickle	sickle	NOUN
gs-4426	368	6	cell	cell	NOUN
gs-4426	368	7	disease	disease	NOUN
gs-4426	368	8	:	:	PUNCT
gs-4426	368	9	recent	recent	ADJ
gs-4426	368	10	advances	advance	NOUN
gs-4426	368	11	and	and	CCONJ
gs-4426	368	12	regulatory	regulatory	ADJ
gs-4426	368	13	approvals	approval	NOUN
gs-4426	368	14	.	.	PUNCT
gs-4426	369	1	blood	blood	NOUN
gs-4426	369	2	articles	article	NOUN
gs-4426	369	3	,	,	PUNCT
gs-4426	369	4	58	58	NUM
gs-4426	369	5	,	,	PUNCT
gs-4426	369	6	101089	101089	NUM
gs-4426	369	7	.	.	PUNCT
gs-4426	370	1	12	12	NUM
gs-4426	370	2	.	.	PUNCT
gs-4426	371	1	singh	singh	PROPN
gs-4426	371	2	,	,	PUNCT
gs-4426	371	3	m.	m.	NOUN
gs-4426	371	4	,	,	PUNCT
gs-4426	371	5	kumar	kumar	PROPN
gs-4426	371	6	,	,	PUNCT
gs-4426	371	7	v.	v.	PROPN
gs-4426	371	8	,	,	PUNCT
gs-4426	371	9	&	&	CCONJ
gs-4426	371	10	sharma	sharma	PROPN
gs-4426	371	11	,	,	PUNCT
gs-4426	371	12	r.	r.	PROPN
gs-4426	371	13	(	(	PUNCT
gs-4426	371	14	2024	2024	NUM
gs-4426	371	15	)	)	PUNCT
gs-4426	371	16	.	.	PUNCT
gs-4426	372	1	bcl11a	bcl11a	X
gs-4426	372	2	targeting	target	VERB
gs-4426	372	3	for	for	ADP
gs-4426	372	4	hemoglobinopathies	hemoglobinopathy	NOUN
gs-4426	372	5	:	:	PUNCT
gs-4426	372	6	from	from	ADP
gs-4426	372	7	bench	bench	NOUN
gs-4426	372	8	to	to	ADP
gs-4426	372	9	bedside	bedside	NOUN
gs-4426	372	10	.	.	PUNCT
gs-4426	373	1	trends	trend	NOUN
gs-4426	373	2	in	in	ADP
gs-4426	373	3	molecular	molecular	ADJ
gs-4426	373	4	medicine	medicine	NOUN
gs-4426	373	5	,	,	PUNCT
gs-4426	373	6	30(2	30(2	NUM
gs-4426	373	7	)	)	PUNCT
gs-4426	373	8	,	,	PUNCT
gs-4426	373	9	156	156	NUM
gs-4426	373	10	-	-	SYM
gs-4426	373	11	169	169	NUM
gs-4426	373	12	.	.	PUNCT
gs-4426	373	13	13	13	NUM
gs-4426	373	14	.	.	PUNCT
gs-4426	374	1	weinberg	weinberg	PROPN
gs-4426	374	2	,	,	PUNCT
gs-4426	374	3	m.	m.	PROPN
gs-4426	374	4	s.	s.	PROPN
gs-4426	374	5	,	,	PUNCT
gs-4426	374	6	samulski	samulski	PROPN
gs-4426	374	7	,	,	PUNCT
gs-4426	374	8	r.	r.	PROPN
gs-4426	374	9	j.	j.	PROPN
gs-4426	374	10	,	,	PUNCT
gs-4426	374	11	&	&	CCONJ
gs-4426	374	12	mccown	mccown	PROPN
gs-4426	374	13	,	,	PUNCT
gs-4426	374	14	t.	t.	PROPN
gs-4426	374	15	j.	j.	PROPN
gs-4426	374	16	(	(	PUNCT
gs-4426	374	17	2013	2013	NUM
gs-4426	374	18	)	)	PUNCT
gs-4426	374	19	.	.	PUNCT
gs-4426	375	1	adeno	adeno	NOUN
gs-4426	375	2	-	-	PUNCT
gs-4426	375	3	associated	associate	VERB
gs-4426	375	4	virus	virus	NOUN
gs-4426	375	5	(	(	PUNCT
gs-4426	375	6	aav	aav	NOUN
gs-4426	375	7	)	)	PUNCT
gs-4426	375	8	gene	gene	NOUN
gs-4426	375	9	therapy	therapy	NOUN
gs-4426	375	10	for	for	ADP
gs-4426	375	11	neurological	neurological	ADJ
gs-4426	375	12	disease	disease	NOUN
gs-4426	375	13	.	.	PUNCT
gs-4426	376	1	neuropharmacology	neuropharmacology	NOUN
gs-4426	376	2	,	,	PUNCT
gs-4426	376	3	69	69	NUM
gs-4426	376	4	,	,	PUNCT
gs-4426	376	5	82	82	NUM
gs-4426	376	6	-	-	SYM
gs-4426	376	7	88	88	NUM
gs-4426	376	8	.	.	PUNCT
gs-4426	377	1	14	14	NUM
gs-4426	377	2	.	.	PUNCT
gs-4426	378	1	wirth	wirth	PROPN
gs-4426	378	2	,	,	PUNCT
gs-4426	378	3	t.	t.	PROPN
gs-4426	378	4	,	,	PUNCT
gs-4426	378	5	parker	parker	PROPN
gs-4426	378	6	,	,	PUNCT
gs-4426	378	7	n.	n.	NOUN
gs-4426	378	8	,	,	PUNCT
gs-4426	378	9	&	&	CCONJ
gs-4426	378	10	ylä	ylä	PROPN
gs-4426	378	11	-	-	PUNCT
gs-4426	378	12	herttuala	herttuala	PROPN
gs-4426	378	13	,	,	PUNCT
gs-4426	378	14	s.	s.	PROPN
gs-4426	378	15	(	(	PUNCT
gs-4426	378	16	2013	2013	NUM
gs-4426	378	17	)	)	PUNCT
gs-4426	378	18	.	.	PUNCT
gs-4426	379	1	history	history	NOUN
gs-4426	379	2	of	of	ADP
gs-4426	379	3	gene	gene	NOUN
gs-4426	379	4	therapy	therapy	NOUN
gs-4426	379	5	.	.	PUNCT
gs-4426	380	1	gene	gene	NOUN
gs-4426	380	2	,	,	PUNCT
gs-4426	380	3	525(2	525(2	NUM
gs-4426	380	4	)	)	PUNCT
gs-4426	380	5	,	,	PUNCT
gs-4426	380	6	162169	162169	NUM
gs-4426	380	7	.	.	PUNCT
gs-4426	381	1	15	15	NUM
gs-4426	381	2	.	.	X
gs-4426	382	1	zhang	zhang	PROPN
gs-4426	382	2	,	,	PUNCT
gs-4426	382	3	x.	x.	PROPN
gs-4426	382	4	,	,	PUNCT
gs-4426	382	5	wang	wang	PROPN
gs-4426	382	6	,	,	PUNCT
gs-4426	382	7	l.	l.	PROPN
gs-4426	382	8	,	,	PUNCT
gs-4426	382	9	&	&	CCONJ
gs-4426	382	10	chen	chen	PROPN
gs-4426	382	11	,	,	PUNCT
gs-4426	382	12	y.	y.	PROPN
gs-4426	382	13	(	(	PUNCT
gs-4426	382	14	2022	2022	NUM
gs-4426	382	15	)	)	PUNCT
gs-4426	382	16	.	.	PUNCT
gs-4426	383	1	car	car	NOUN
gs-4426	383	2	-	-	PUNCT
gs-4426	383	3	t	t	NOUN
gs-4426	383	4	cell	cell	NOUN
gs-4426	383	5	therapy	therapy	NOUN
gs-4426	383	6	manufacturing	manufacturing	NOUN
gs-4426	383	7	and	and	CCONJ
gs-4426	383	8	clinical	clinical	ADJ
gs-4426	383	9	applications	application	NOUN
gs-4426	383	10	:	:	PUNCT
gs-4426	383	11	current	current	ADJ
gs-4426	383	12	status	status	NOUN
gs-4426	383	13	and	and	CCONJ
gs-4426	383	14	future	future	ADJ
gs-4426	383	15	directions	direction	NOUN
gs-4426	383	16	.	.	PUNCT
gs-4426	384	1	frontiers	frontier	NOUN
gs-4426	384	2	in	in	ADP
gs-4426	384	3	immunology	immunology	NOUN
gs-4426	384	4	,	,	PUNCT
gs-4426	384	5	13	13	NUM
gs-4426	384	6	,	,	PUNCT
gs-4426	384	7	923022	923022	NUM
gs-4426	384	8	.	.	PUNCT
gs-4426	385	1	16	16	NUM
gs-4426	385	2	.	.	PUNCT
gs-4426	386	1	aphkhazava	aphkhazava	PROPN
gs-4426	386	2	,	,	PUNCT
gs-4426	386	3	d.	d.	PROPN
gs-4426	386	4	,	,	PUNCT
gs-4426	386	5	sulashvili	sulashvili	NOUN
gs-4426	386	6	,	,	PUNCT
gs-4426	386	7	n.	n.	NOUN
gs-4426	386	8	,	,	PUNCT
gs-4426	386	9	&	&	CCONJ
gs-4426	386	10	tkemaladze	tkemaladze	PROPN
gs-4426	386	11	,	,	PUNCT
gs-4426	386	12	j.	j.	PROPN
gs-4426	386	13	(	(	PUNCT
gs-4426	386	14	2025	2025	NUM
gs-4426	386	15	)	)	PUNCT
gs-4426	386	16	.	.	PUNCT
gs-4426	387	1	stem	stem	NOUN
gs-4426	387	2	cell	cell	NOUN
gs-4426	387	3	systems	system	NOUN
gs-4426	387	4	and	and	CCONJ
gs-4426	387	5	regeneration	regeneration	NOUN
gs-4426	387	6	.	.	PUNCT
gs-4426	388	1	georgian	georgian	ADJ
gs-4426	388	2	scientists	scientist	NOUN
gs-4426	388	3	,	,	PUNCT
gs-4426	388	4	7(1	7(1	NUM
gs-4426	388	5	)	)	PUNCT
gs-4426	388	6	,	,	PUNCT
gs-4426	388	7	271–319	271–319	NUM
gs-4426	388	8	.	.	PUNCT
gs-4426	389	1	https://doi.org/10.52340/gs.2025.07.01.26	https://doi.org/10.52340/gs.2025.07.01.26	NOUN
gs-4426	389	2	.	.	NOUN
gs-4426	389	3	17	17	NUM
gs-4426	389	4	.	.	PUNCT
gs-4426	389	5	high	high	ADJ
gs-4426	389	6	,	,	PUNCT
gs-4426	389	7	k.	k.	PROPN
gs-4426	389	8	a.	a.	PROPN
gs-4426	389	9	,	,	PUNCT
gs-4426	389	10	&	&	CCONJ
gs-4426	389	11	roncarolo	roncarolo	PROPN
gs-4426	389	12	,	,	PUNCT
gs-4426	389	13	m.	m.	NOUN
gs-4426	389	14	g.	g.	PROPN
gs-4426	389	15	(	(	PUNCT
gs-4426	389	16	2019	2019	NUM
gs-4426	389	17	)	)	PUNCT
gs-4426	389	18	.	.	PUNCT
gs-4426	390	1	gene	gene	NOUN
gs-4426	390	2	therapy	therapy	NOUN
gs-4426	390	3	.	.	PUNCT
gs-4426	391	1	new	new	PROPN
gs-4426	391	2	england	england	PROPN
gs-4426	391	3	journal	journal	PROPN
gs-4426	391	4	of	of	ADP
gs-4426	391	5	medicine	medicine	NOUN
gs-4426	391	6	,	,	PUNCT
gs-4426	391	7	381(5	381(5	NUM
gs-4426	391	8	)	)	PUNCT
gs-4426	391	9	,	,	PUNCT
gs-4426	391	10	455–464	455–464	NUM
gs-4426	391	11	.	.	PROPN
gs-4426	392	1	18	18	NUM
gs-4426	392	2	.	.	X
gs-4426	392	3	doudna	doudna	PROPN
gs-4426	392	4	,	,	PUNCT
gs-4426	392	5	j.	j.	PROPN
gs-4426	392	6	a.	a.	PROPN
gs-4426	392	7	,	,	PUNCT
gs-4426	392	8	&	&	CCONJ
gs-4426	392	9	charpentier	charpentier	PROPN
gs-4426	392	10	,	,	PUNCT
gs-4426	392	11	e.	e.	PROPN
gs-4426	392	12	(	(	PUNCT
gs-4426	392	13	2014	2014	NUM
gs-4426	392	14	)	)	PUNCT
gs-4426	392	15	.	.	PUNCT
gs-4426	393	1	the	the	DET
gs-4426	393	2	new	new	ADJ
gs-4426	393	3	frontier	frontier	NOUN
gs-4426	393	4	of	of	ADP
gs-4426	393	5	genome	genome	NOUN
gs-4426	393	6	engineering	engineering	NOUN
gs-4426	393	7	with	with	ADP
gs-4426	393	8	crisprcas9	crisprcas9	NOUN
gs-4426	393	9	.	.	PUNCT
gs-4426	394	1	science	science	NOUN
gs-4426	394	2	,	,	PUNCT
gs-4426	394	3	346(6213	346(6213	NUM
gs-4426	394	4	)	)	PUNCT
gs-4426	394	5	,	,	PUNCT
gs-4426	394	6	1258096	1258096	NUM
gs-4426	394	7	.	.	PUNCT
gs-4426	395	1	19	19	NUM
gs-4426	395	2	.	.	X
gs-4426	395	3	urnov	urnov	PROPN
gs-4426	395	4	,	,	PUNCT
gs-4426	395	5	f.	f.	PROPN
gs-4426	395	6	d.	d.	PROPN
gs-4426	395	7	,	,	PUNCT
gs-4426	395	8	ronald	ronald	PROPN
gs-4426	395	9	,	,	PUNCT
gs-4426	395	10	m.	m.	NOUN
gs-4426	395	11	,	,	PUNCT
gs-4426	395	12	holmes	holmes	PROPN
gs-4426	395	13	,	,	PUNCT
gs-4426	395	14	m.	m.	PROPN
gs-4426	395	15	c.	c.	PROPN
gs-4426	395	16	,	,	PUNCT
gs-4426	395	17	&	&	CCONJ
gs-4426	395	18	gregory	gregory	PROPN
gs-4426	395	19	,	,	PUNCT
gs-4426	395	20	p.	p.	PROPN
gs-4426	395	21	d.	d.	PROPN
gs-4426	395	22	(	(	PUNCT
gs-4426	395	23	2010	2010	NUM
gs-4426	395	24	)	)	PUNCT
gs-4426	395	25	.	.	PUNCT
gs-4426	396	1	genome	genome	NOUN
gs-4426	396	2	editing	editing	NOUN
gs-4426	396	3	with	with	ADP
gs-4426	396	4	engineered	engineer	VERB
gs-4426	396	5	nucleases	nuclease	NOUN
gs-4426	396	6	.	.	PUNCT
gs-4426	397	1	nature	nature	NOUN
gs-4426	397	2	reviews	review	VERB
gs-4426	397	3	genetics	genetic	NOUN
gs-4426	397	4	,	,	PUNCT
gs-4426	397	5	11(9	11(9	PROPN
gs-4426	397	6	)	)	PUNCT
gs-4426	397	7	,	,	PUNCT
gs-4426	397	8	636–646	636–646	NUM
gs-4426	397	9	.	.	PROPN
gs-4426	398	1	20	20	NUM
gs-4426	398	2	.	.	PUNCT
gs-4426	398	3	bulcha	bulcha	PROPN
gs-4426	398	4	,	,	PUNCT
gs-4426	398	5	j.	j.	PROPN
gs-4426	398	6	t.	t.	PROPN
gs-4426	398	7	,	,	PUNCT
gs-4426	398	8	wang	wang	PROPN
gs-4426	398	9	,	,	PUNCT
gs-4426	398	10	y.	y.	PROPN
gs-4426	398	11	,	,	PUNCT
gs-4426	398	12	ma	ma	PROPN
gs-4426	398	13	,	,	PUNCT
gs-4426	398	14	h.	h.	PROPN
gs-4426	398	15	,	,	PUNCT
gs-4426	398	16	tai	tai	PROPN
gs-4426	398	17	,	,	PUNCT
gs-4426	398	18	p.	p.	PROPN
gs-4426	398	19	w.	w.	PROPN
gs-4426	398	20	l.	l.	PROPN
gs-4426	398	21	,	,	PUNCT
gs-4426	398	22	&	&	CCONJ
gs-4426	398	23	gao	gao	PROPN
gs-4426	398	24	,	,	PUNCT
gs-4426	398	25	g.	g.	PROPN
gs-4426	398	26	(	(	PUNCT
gs-4426	398	27	2021	2021	NUM
gs-4426	398	28	)	)	PUNCT
gs-4426	398	29	.	.	PUNCT
gs-4426	399	1	viral	viral	ADJ
gs-4426	399	2	vector	vector	NOUN
gs-4426	399	3	platforms	platform	NOUN
gs-4426	399	4	within	within	ADP
gs-4426	399	5	the	the	DET
gs-4426	399	6	gene	gene	NOUN
gs-4426	399	7	therapy	therapy	NOUN
gs-4426	399	8	landscape	landscape	NOUN
gs-4426	399	9	.	.	PUNCT
gs-4426	400	1	signal	signal	ADJ
gs-4426	400	2	transduction	transduction	NOUN
gs-4426	400	3	and	and	CCONJ
gs-4426	400	4	targeted	target	VERB
gs-4426	400	5	therapy	therapy	NOUN
gs-4426	400	6	,	,	PUNCT
gs-4426	400	7	6(1	6(1	NUM
gs-4426	400	8	)	)	PUNCT
gs-4426	400	9	,	,	PUNCT
gs-4426	400	10	1–24	1–24	PROPN
gs-4426	400	11	.	.	PUNCT
gs-4426	401	1	21	21	NUM
gs-4426	401	2	.	.	PUNCT
gs-4426	401	3	naldini	naldini	PROPN
gs-4426	401	4	,	,	PUNCT
gs-4426	401	5	l.	l.	PROPN
gs-4426	401	6	(	(	PUNCT
gs-4426	401	7	2015	2015	NUM
gs-4426	401	8	)	)	PUNCT
gs-4426	401	9	.	.	PUNCT
gs-4426	402	1	gene	gene	NOUN
gs-4426	402	2	therapy	therapy	NOUN
gs-4426	402	3	returns	return	VERB
gs-4426	402	4	to	to	ADP
gs-4426	402	5	centre	centre	NOUN
gs-4426	402	6	stage	stage	NOUN
gs-4426	402	7	.	.	PUNCT
gs-4426	403	1	nature	nature	NOUN
gs-4426	403	2	,	,	PUNCT
gs-4426	403	3	526(7573	526(7573	NUM
gs-4426	403	4	)	)	PUNCT
gs-4426	403	5	,	,	PUNCT
gs-4426	403	6	351–360	351–360	NUM
gs-4426	403	7	.	.	PUNCT
gs-4426	404	1	22	22	NUM
gs-4426	404	2	.	.	PUNCT
gs-4426	405	1	esensten	esensten	PROPN
gs-4426	405	2	,	,	PUNCT
gs-4426	405	3	j.	j.	PROPN
gs-4426	405	4	h.	h.	PROPN
gs-4426	405	5	,	,	PUNCT
gs-4426	405	6	bluestone	bluestone	NOUN
gs-4426	405	7	,	,	PUNCT
gs-4426	405	8	j.	j.	PROPN
gs-4426	405	9	a.	a.	PROPN
gs-4426	405	10	,	,	PUNCT
gs-4426	405	11	&	&	CCONJ
gs-4426	405	12	lim	lim	PROPN
gs-4426	405	13	,	,	PUNCT
gs-4426	405	14	w.	w.	PROPN
gs-4426	405	15	a.	a.	PROPN
gs-4426	405	16	(	(	PUNCT
gs-4426	405	17	2017	2017	NUM
gs-4426	405	18	)	)	PUNCT
gs-4426	405	19	.	.	PUNCT
gs-4426	406	1	engineering	engineer	VERB
gs-4426	406	2	therapeutic	therapeutic	ADJ
gs-4426	406	3	t	t	NOUN
gs-4426	406	4	cells	cell	NOUN
gs-4426	406	5	:	:	PUNCT
gs-4426	406	6	from	from	ADP
gs-4426	406	7	synthetic	synthetic	ADJ
gs-4426	406	8	biology	biology	NOUN
gs-4426	406	9	to	to	ADP
gs-4426	406	10	clinical	clinical	ADJ
gs-4426	406	11	trials	trial	NOUN
gs-4426	406	12	.	.	PUNCT
gs-4426	407	1	annual	annual	ADJ
gs-4426	407	2	review	review	NOUN
gs-4426	407	3	of	of	ADP
gs-4426	407	4	pathology	pathology	NOUN
gs-4426	407	5	:	:	PUNCT
gs-4426	407	6	mechanisms	mechanism	NOUN
gs-4426	407	7	of	of	ADP
gs-4426	407	8	disease	disease	NOUN
gs-4426	407	9	,	,	PUNCT
gs-4426	407	10	12	12	NUM
gs-4426	407	11	,	,	PUNCT
gs-4426	407	12	305–330	305–330	NUM
gs-4426	407	13	.	.	NOUN
gs-4426	407	14	23	23	NUM
gs-4426	407	15	.	.	PUNCT
gs-4426	408	1	june	june	PROPN
gs-4426	408	2	,	,	PUNCT
gs-4426	408	3	c.	c.	PROPN
gs-4426	408	4	h.	h.	PROPN
gs-4426	408	5	,	,	PUNCT
gs-4426	408	6	o’connor	o’connor	ADV
gs-4426	408	7	,	,	PUNCT
gs-4426	408	8	r.	r.	PROPN
gs-4426	408	9	s.	s.	PROPN
gs-4426	408	10	,	,	PUNCT
gs-4426	408	11	kawalekar	kawalekar	PROPN
gs-4426	408	12	,	,	PUNCT
gs-4426	408	13	o.	o.	PROPN
gs-4426	408	14	u.	u.	PROPN
gs-4426	408	15	,	,	PUNCT
gs-4426	408	16	ghassemi	ghassemi	PROPN
gs-4426	408	17	,	,	PUNCT
gs-4426	408	18	s.	s.	PROPN
gs-4426	408	19	,	,	PUNCT
gs-4426	408	20	&	&	CCONJ
gs-4426	408	21	milone	milone	NOUN
gs-4426	408	22	,	,	PUNCT
gs-4426	408	23	m.	m.	NOUN
gs-4426	408	24	c.	c.	PROPN
gs-4426	408	25	(	(	PUNCT
gs-4426	408	26	2018	2018	NUM
gs-4426	408	27	)	)	PUNCT
gs-4426	408	28	.	.	PUNCT
gs-4426	409	1	car	car	NOUN
gs-4426	409	2	t	t	PROPN
gs-4426	409	3	cell	cell	NOUN
gs-4426	409	4	immunotherapy	immunotherapy	NOUN
gs-4426	409	5	for	for	ADP
gs-4426	409	6	human	human	ADJ
gs-4426	409	7	cancer	cancer	NOUN
gs-4426	409	8	.	.	PUNCT
gs-4426	410	1	science	science	NOUN
gs-4426	410	2	,	,	PUNCT
gs-4426	410	3	359(6382	359(6382	NUM
gs-4426	410	4	)	)	PUNCT
gs-4426	410	5	,	,	PUNCT
gs-4426	410	6	1361–1365	1361–1365	NUM
gs-4426	410	7	.	.	PUNCT
gs-4426	411	1	24	24	NUM
gs-4426	411	2	.	.	PUNCT
gs-4426	411	3	sulashvili	sulashvili	NOUN
gs-4426	411	4	,	,	PUNCT
gs-4426	411	5	n.	n.	PROPN
gs-4426	411	6	,	,	PUNCT
gs-4426	411	7	jadhav	jadhav	PROPN
gs-4426	411	8	,	,	PUNCT
gs-4426	411	9	r.	r.	PROPN
gs-4426	411	10	d.	d.	PROPN
gs-4426	411	11	,	,	PUNCT
gs-4426	411	12	beglaryan	beglaryan	ADJ
gs-4426	411	13	,	,	PUNCT
gs-4426	411	14	m.	m.	NOUN
gs-4426	411	15	,	,	PUNCT
gs-4426	411	16	gabunia	gabunia	NOUN
gs-4426	411	17	,	,	PUNCT
gs-4426	411	18	l.	l.	PROPN
gs-4426	411	19	,	,	PUNCT
gs-4426	411	20	gorgaslidze	gorgaslidze	PROPN
gs-4426	411	21	,	,	PUNCT
gs-4426	411	22	n.	n.	NOUN
gs-4426	411	23	,	,	PUNCT
gs-4426	411	24	alavidze	alavidze	PROPN
gs-4426	411	25	,	,	PUNCT
gs-4426	411	26	n.	n.	NOUN
gs-4426	411	27	,	,	PUNCT
gs-4426	411	28	…	…	PUNCT
gs-4426	411	29	robakidze	robakidze	X
gs-4426	411	30	,	,	PUNCT
gs-4426	411	31	k.	k.	PROPN
gs-4426	411	32	(	(	PUNCT
gs-4426	411	33	2025	2025	NUM
gs-4426	411	34	)	)	PUNCT
gs-4426	411	35	.	.	PUNCT
gs-4426	412	1	the	the	DET
gs-4426	412	2	scientific	scientific	ADJ
gs-4426	412	3	discussion	discussion	NOUN
gs-4426	412	4	of	of	ADP
gs-4426	412	5	key	key	ADJ
gs-4426	412	6	issue	issue	NOUN
gs-4426	412	7	aspects	aspect	NOUN
gs-4426	412	8	of	of	ADP
gs-4426	412	9	immunopathogenesis	immunopathogenesis	NOUN
gs-4426	412	10	and	and	CCONJ
gs-4426	412	11	pharmacological	pharmacological	NOUN
gs-4426	412	12	properties	property	NOUN
gs-4426	412	13	and	and	CCONJ
gs-4426	412	14	profiles	profile	NOUN
gs-4426	412	15	in	in	ADP
gs-4426	412	16	relation	relation	NOUN
gs-4426	412	17	to	to	ADP
gs-4426	412	18	adverse	adverse	ADJ
gs-4426	412	19	drug	drug	NOUN
gs-4426	412	20	reactions	reaction	NOUN
gs-4426	412	21	challenges	challenge	NOUN
gs-4426	412	22	,	,	PUNCT
gs-4426	412	23	focus	focus	VERB
gs-4426	412	24	on	on	ADP
gs-4426	412	25	multidimensional	multidimensional	ADJ
gs-4426	412	26	drug	drug	NOUN
gs-4426	412	27	-	-	PUNCT
gs-4426	412	28	induced	induce	VERB
gs-4426	412	29	eosinophilia	eosinophilia	NOUN
gs-4426	412	30	and	and	CCONJ
gs-4426	412	31	systemic	systemic	ADJ
gs-4426	412	32	syndrome	syndrome	NOUN
gs-4426	412	33	.	.	PUNCT
gs-4426	413	1	georgian	georgian	ADJ
gs-4426	413	2	scientists	scientist	NOUN
gs-4426	413	3	,	,	PUNCT
gs-4426	413	4	7(3	7(3	NUM
gs-4426	413	5	)	)	PUNCT
gs-4426	413	6	,	,	PUNCT
gs-4426	413	7	141–179	141–179	NUM
gs-4426	413	8	.	.	PUNCT
gs-4426	414	1	https://doi.org/10.52340/gs.2025.07.03.13	https://doi.org/10.52340/gs.2025.07.03.13	X
gs-4426	414	2	.	.	PUNCT
gs-4426	415	1	25	25	NUM
gs-4426	415	2	.	.	PUNCT
gs-4426	416	1	ylä	ylä	NOUN
gs-4426	416	2	-	-	PUNCT
gs-4426	416	3	herttuala	herttuala	PROPN
gs-4426	416	4	,	,	PUNCT
gs-4426	416	5	s.	s.	PROPN
gs-4426	416	6	(	(	PUNCT
gs-4426	416	7	2012	2012	NUM
gs-4426	416	8	)	)	PUNCT
gs-4426	416	9	.	.	PUNCT
gs-4426	417	1	endgame	endgame	NOUN
gs-4426	417	2	:	:	PUNCT
gs-4426	417	3	glybera	glybera	NOUN
gs-4426	417	4	finally	finally	ADV
gs-4426	417	5	recommended	recommend	VERB
gs-4426	417	6	for	for	ADP
gs-4426	417	7	approval	approval	NOUN
gs-4426	417	8	as	as	ADP
gs-4426	417	9	the	the	DET
gs-4426	417	10	first	first	ADJ
gs-4426	417	11	gene	gene	NOUN
gs-4426	417	12	therapy	therapy	NOUN
gs-4426	417	13	drug	drug	NOUN
gs-4426	417	14	in	in	ADP
gs-4426	417	15	the	the	DET
gs-4426	417	16	european	european	PROPN
gs-4426	417	17	union	union	PROPN
gs-4426	417	18	.	.	PUNCT
gs-4426	418	1	molecular	molecular	ADJ
gs-4426	418	2	therapy	therapy	NOUN
gs-4426	418	3	,	,	PUNCT
gs-4426	418	4	20(10	20(10	NUM
gs-4426	418	5	)	)	PUNCT
gs-4426	418	6	,	,	PUNCT
gs-4426	418	7	1831–1832	1831–1832	NUM
gs-4426	418	8	.	.	NOUN
gs-4426	418	9	26	26	NUM
gs-4426	418	10	.	.	PUNCT
gs-4426	419	1	wang	wang	PROPN
gs-4426	419	2	,	,	PUNCT
gs-4426	419	3	d.	d.	PROPN
gs-4426	419	4	,	,	PUNCT
gs-4426	419	5	tai	tai	PROPN
gs-4426	419	6	,	,	PUNCT
gs-4426	419	7	p.	p.	PROPN
gs-4426	419	8	w.	w.	PROPN
gs-4426	419	9	l.	l.	PROPN
gs-4426	419	10	,	,	PUNCT
gs-4426	419	11	&	&	CCONJ
gs-4426	419	12	gao	gao	PROPN
gs-4426	419	13	,	,	PUNCT
gs-4426	419	14	g.	g.	PROPN
gs-4426	419	15	(	(	PUNCT
gs-4426	419	16	2019	2019	NUM
gs-4426	419	17	)	)	PUNCT
gs-4426	419	18	.	.	PUNCT
gs-4426	420	1	adeno	adeno	NOUN
gs-4426	420	2	-	-	PUNCT
gs-4426	420	3	associated	associate	VERB
gs-4426	420	4	virus	virus	NOUN
gs-4426	420	5	vector	vector	NOUN
gs-4426	420	6	as	as	ADP
gs-4426	420	7	a	a	DET
gs-4426	420	8	platform	platform	NOUN
gs-4426	420	9	for	for	ADP
gs-4426	420	10	gene	gene	NOUN
gs-4426	420	11	therapy	therapy	NOUN
gs-4426	420	12	delivery	delivery	NOUN
gs-4426	420	13	.	.	PUNCT
gs-4426	421	1	nature	nature	NOUN
gs-4426	421	2	reviews	review	VERB
gs-4426	421	3	drug	drug	NOUN
gs-4426	421	4	discovery	discovery	NOUN
gs-4426	421	5	,	,	PUNCT
gs-4426	421	6	18(5	18(5	NUM
gs-4426	421	7	)	)	PUNCT
gs-4426	421	8	,	,	PUNCT
gs-4426	421	9	358–378	358–378	NUM
gs-4426	421	10	.	.	PUNCT
gs-4426	422	1	27	27	NUM
gs-4426	422	2	.	.	PUNCT
gs-4426	423	1	eyquem	eyquem	PROPN
gs-4426	423	2	,	,	PUNCT
gs-4426	423	3	j.	j.	PROPN
gs-4426	423	4	,	,	PUNCT
gs-4426	423	5	mansilla	mansilla	PROPN
gs-4426	423	6	-	-	PUNCT
gs-4426	423	7	soto	soto	PROPN
gs-4426	423	8	,	,	PUNCT
gs-4426	423	9	j.	j.	PROPN
gs-4426	423	10	,	,	PUNCT
gs-4426	423	11	giavridis	giavridis	PROPN
gs-4426	423	12	,	,	PUNCT
gs-4426	423	13	t.	t.	PROPN
gs-4426	423	14	,	,	PUNCT
gs-4426	423	15	van	van	PROPN
gs-4426	423	16	der	der	PROPN
gs-4426	423	17	stegen	stegen	NOUN
gs-4426	423	18	,	,	PUNCT
gs-4426	423	19	s.	s.	PROPN
gs-4426	423	20	j.	j.	PROPN
gs-4426	423	21	c.	c.	PROPN
gs-4426	423	22	,	,	PUNCT
gs-4426	423	23	hamieh	hamieh	PROPN
gs-4426	423	24	,	,	PUNCT
gs-4426	423	25	m.	m.	NOUN
gs-4426	423	26	,	,	PUNCT
gs-4426	423	27	cunanan	cunanan	PROPN
gs-4426	423	28	,	,	PUNCT
gs-4426	423	29	k.	k.	PROPN
gs-4426	423	30	m.	m.	PROPN
gs-4426	423	31	,	,	PUNCT
gs-4426	423	32	odak	odak	PROPN
gs-4426	423	33	,	,	PUNCT
gs-4426	423	34	a.	a.	NOUN
gs-4426	423	35	,	,	PUNCT
gs-4426	423	36	&	&	CCONJ
gs-4426	423	37	sadelain	sadelain	PROPN
gs-4426	423	38	,	,	PUNCT
gs-4426	423	39	m.	m.	NOUN
gs-4426	423	40	(	(	PUNCT
gs-4426	423	41	2017	2017	NUM
gs-4426	423	42	)	)	PUNCT
gs-4426	423	43	.	.	PUNCT
gs-4426	424	1	targeting	target	VERB
gs-4426	424	2	a	a	DET
gs-4426	424	3	car	car	NOUN
gs-4426	424	4	to	to	ADP
gs-4426	424	5	the	the	DET
gs-4426	424	6	trac	trac	NOUN
gs-4426	424	7	locus	locus	NOUN
gs-4426	424	8	with	with	ADP
gs-4426	424	9	crispr	crispr	ADJ
gs-4426	424	10	/	/	SYM
gs-4426	424	11	cas9	cas9	NOUN
gs-4426	424	12	enhances	enhance	VERB
gs-4426	424	13	tumour	tumour	ADJ
gs-4426	424	14	rejection	rejection	NOUN
gs-4426	424	15	.	.	PUNCT
gs-4426	425	1	nature	nature	NOUN
gs-4426	425	2	,	,	PUNCT
gs-4426	425	3	543(7643	543(7643	NUM
gs-4426	425	4	)	)	PUNCT
gs-4426	425	5	,	,	PUNCT
gs-4426	425	6	113–117	113–117	NUM
gs-4426	425	7	.	.	PUNCT
gs-4426	426	1	28	28	NUM
gs-4426	426	2	.	.	PUNCT
gs-4426	427	1	dunbar	dunbar	PROPN
gs-4426	427	2	,	,	PUNCT
gs-4426	427	3	c.	c.	PROPN
gs-4426	427	4	e.	e.	PROPN
gs-4426	427	5	,	,	PUNCT
gs-4426	427	6	high	high	PROPN
gs-4426	427	7	,	,	PUNCT
gs-4426	427	8	k.	k.	PROPN
gs-4426	427	9	a.	a.	PROPN
gs-4426	427	10	,	,	PUNCT
gs-4426	427	11	joung	joung	PROPN
gs-4426	427	12	,	,	PUNCT
gs-4426	427	13	j.	j.	PROPN
gs-4426	427	14	k.	k.	PROPN
gs-4426	427	15	,	,	PUNCT
gs-4426	427	16	kohn	kohn	PROPN
gs-4426	427	17	,	,	PUNCT
gs-4426	427	18	d.	d.	PROPN
gs-4426	427	19	b.	b.	PROPN
gs-4426	427	20	,	,	PUNCT
gs-4426	427	21	ozawa	ozawa	PROPN
gs-4426	427	22	,	,	PUNCT
gs-4426	427	23	k.	k.	PROPN
gs-4426	427	24	,	,	PUNCT
gs-4426	427	25	&	&	CCONJ
gs-4426	427	26	sadelain	sadelain	PROPN
gs-4426	427	27	,	,	PUNCT
gs-4426	427	28	m.	m.	NOUN
gs-4426	427	29	(	(	PUNCT
gs-4426	427	30	2018	2018	NUM
gs-4426	427	31	)	)	PUNCT
gs-4426	427	32	.	.	PUNCT
gs-4426	428	1	gene	gene	NOUN
gs-4426	428	2	therapy	therapy	NOUN
gs-4426	428	3	comes	come	VERB
gs-4426	428	4	of	of	ADP
gs-4426	428	5	age	age	NOUN
gs-4426	428	6	.	.	PUNCT
gs-4426	429	1	science	science	NOUN
gs-4426	429	2	,	,	PUNCT
gs-4426	429	3	359(6372	359(6372	NUM
gs-4426	429	4	)	)	PUNCT
gs-4426	429	5	,	,	PUNCT
gs-4426	429	6	eaan4672	eaan4672	PROPN
gs-4426	429	7	.	.	PUNCT
gs-4426	430	1	29	29	NUM
gs-4426	430	2	.	.	X
gs-4426	431	1	abel	abel	PROPN
gs-4426	431	2	,	,	PUNCT
gs-4426	431	3	t.	t.	PROPN
gs-4426	431	4	,	,	PUNCT
gs-4426	431	5	&	&	CCONJ
gs-4426	431	6	gao	gao	PROPN
gs-4426	431	7	,	,	PUNCT
gs-4426	431	8	g.	g.	PROPN
gs-4426	431	9	(	(	PUNCT
gs-4426	431	10	2020	2020	NUM
gs-4426	431	11	)	)	PUNCT
gs-4426	431	12	.	.	PUNCT
gs-4426	432	1	overcoming	overcome	VERB
gs-4426	432	2	barriers	barrier	NOUN
gs-4426	432	3	to	to	ADP
gs-4426	432	4	clinical	clinical	ADJ
gs-4426	432	5	translation	translation	NOUN
gs-4426	432	6	of	of	ADP
gs-4426	432	7	aav	aav	PROPN
gs-4426	432	8	gene	gene	NOUN
gs-4426	432	9	therapy	therapy	NOUN
gs-4426	432	10	.	.	PUNCT
gs-4426	433	1	nature	nature	NOUN
gs-4426	433	2	medicine	medicine	NOUN
gs-4426	433	3	,	,	PUNCT
gs-4426	433	4	26(6	26(6	NUM
gs-4426	433	5	)	)	PUNCT
gs-4426	433	6	,	,	PUNCT
gs-4426	433	7	857–869	857–869	NUM
gs-4426	433	8	.	.	PUNCT
gs-4426	434	1	georgian	georgian	NOUN
gs-4426	434	2	scientists/	scientists/	NUM
gs-4426	434	3	.	.	PUNCT
gs-4426	435	1	7	7	NUM
gs-4426	435	2	n	n	DET
gs-4426	435	3	4	4	NUM
gs-4426	435	4	,	,	PUNCT
gs-4426	435	5	2025	2025	NUM
gs-4426	435	6	619	619	NUM
gs-4426	435	7	30	30	NUM
gs-4426	435	8	.	.	PUNCT
gs-4426	436	1	sulashvili	sulashvili	NOUN
gs-4426	436	2	,	,	PUNCT
gs-4426	436	3	n.	n.	NOUN
gs-4426	436	4	,	,	PUNCT
gs-4426	436	5	patsia	patsia	PROPN
gs-4426	436	6	,	,	PUNCT
gs-4426	436	7	l.	l.	PROPN
gs-4426	436	8	,	,	PUNCT
gs-4426	436	9	el	el	PROPN
gs-4426	436	10	-	-	PUNCT
gs-4426	436	11	hakeem	hakeem	PROPN
gs-4426	436	12	,	,	PUNCT
gs-4426	436	13	a.	a.	PROPN
gs-4426	436	14	,	,	PUNCT
gs-4426	436	15	ayaan	ayaan	PROPN
gs-4426	436	16	,	,	PUNCT
gs-4426	436	17	s.	s.	PROPN
gs-4426	436	18	,	,	PUNCT
gs-4426	436	19	hizomi	hizomi	PROPN
gs-4426	436	20	,	,	PUNCT
gs-4426	436	21	a.	a.	NOUN
gs-4426	436	22	,	,	PUNCT
gs-4426	436	23	agarwal	agarwal	PROPN
gs-4426	436	24	,	,	PUNCT
gs-4426	436	25	s.	s.	PROPN
gs-4426	436	26	,	,	PUNCT
gs-4426	436	27	&	&	CCONJ
gs-4426	436	28	sulashvili	sulashvili	NOUN
gs-4426	436	29	,	,	PUNCT
gs-4426	436	30	m.	m.	NOUN
gs-4426	436	31	(	(	PUNCT
gs-4426	436	32	2025	2025	NUM
gs-4426	436	33	)	)	PUNCT
gs-4426	436	34	.	.	PUNCT
gs-4426	437	1	exploring	explore	VERB
gs-4426	437	2	the	the	DET
gs-4426	437	3	gut	gut	NOUN
gs-4426	437	4	-	-	PUNCT
gs-4426	437	5	brain	brain	NOUN
gs-4426	437	6	axis	axis	NOUN
gs-4426	437	7	:	:	PUNCT
gs-4426	437	8	the	the	DET
gs-4426	437	9	role	role	NOUN
gs-4426	437	10	of	of	ADP
gs-4426	437	11	the	the	DET
gs-4426	437	12	microbiome	microbiome	NOUN
gs-4426	437	13	in	in	ADP
gs-4426	437	14	modulating	modulate	VERB
gs-4426	437	15	brain	brain	NOUN
gs-4426	437	16	function	function	NOUN
gs-4426	437	17	and	and	CCONJ
gs-4426	437	18	its	its	PRON
gs-4426	437	19	implications	implication	NOUN
gs-4426	437	20	in	in	ADP
gs-4426	437	21	neurodegenerative	neurodegenerative	ADJ
gs-4426	437	22	disorders	disorder	NOUN
gs-4426	437	23	like	like	ADP
gs-4426	437	24	parkinson	parkinson	NOUN
gs-4426	437	25	’s	’s	PART
gs-4426	437	26	and	and	CCONJ
gs-4426	437	27	alzheimer	alzheimer	PROPN
gs-4426	437	28	’s	’s	PART
gs-4426	437	29	and	and	CCONJ
gs-4426	437	30	pharmacotherapy	pharmacotherapy	NOUN
gs-4426	437	31	treatment	treatment	NOUN
gs-4426	437	32	strategies	strategy	NOUN
gs-4426	437	33	.	.	PUNCT
gs-4426	438	1	georgian	georgian	ADJ
gs-4426	438	2	scientists	scientist	NOUN
gs-4426	438	3	,	,	PUNCT
gs-4426	438	4	7(2	7(2	NUM
gs-4426	438	5	)	)	PUNCT
gs-4426	438	6	,	,	PUNCT
gs-4426	438	7	329–353	329–353	PROPN
gs-4426	438	8	.	.	PUNCT
gs-4426	439	1	https://doi.org/10.52340/gs.2025.07.02.32	https://doi.org/10.52340/gs.2025.07.02.32	PROPN
gs-4426	439	2	31	31	NUM
gs-4426	439	3	.	.	PUNCT
gs-4426	440	1	porter	porter	NOUN
gs-4426	440	2	,	,	PUNCT
gs-4426	440	3	d.	d.	PROPN
gs-4426	440	4	l.	l.	PROPN
gs-4426	440	5	,	,	PUNCT
gs-4426	440	6	levine	levine	PROPN
gs-4426	440	7	,	,	PUNCT
gs-4426	440	8	b.	b.	PROPN
gs-4426	440	9	l.	l.	PROPN
gs-4426	440	10	,	,	PUNCT
gs-4426	440	11	kalos	kalos	PROPN
gs-4426	440	12	,	,	PUNCT
gs-4426	440	13	m.	m.	NOUN
gs-4426	440	14	,	,	PUNCT
gs-4426	440	15	bagg	bagg	PROPN
gs-4426	440	16	,	,	PUNCT
gs-4426	440	17	a.	a.	PROPN
gs-4426	440	18	,	,	PUNCT
gs-4426	440	19	&	&	CCONJ
gs-4426	440	20	june	june	PROPN
gs-4426	440	21	,	,	PUNCT
gs-4426	440	22	c.	c.	PROPN
gs-4426	440	23	h.	h.	PROPN
gs-4426	440	24	(	(	PUNCT
gs-4426	440	25	2011	2011	NUM
gs-4426	440	26	)	)	PUNCT
gs-4426	440	27	.	.	PUNCT
gs-4426	441	1	chimeric	chimeric	ADJ
gs-4426	441	2	antigen	antigen	NOUN
gs-4426	441	3	receptormodified	receptormodifie	VERB
gs-4426	441	4	t	t	NOUN
gs-4426	441	5	cells	cell	NOUN
gs-4426	441	6	in	in	ADP
gs-4426	441	7	chronic	chronic	ADJ
gs-4426	441	8	lymphoid	lymphoid	NOUN
gs-4426	441	9	leukemia	leukemia	NOUN
gs-4426	441	10	.	.	PUNCT
gs-4426	442	1	new	new	PROPN
gs-4426	442	2	england	england	PROPN
gs-4426	442	3	journal	journal	PROPN
gs-4426	442	4	of	of	ADP
gs-4426	442	5	medicine	medicine	NOUN
gs-4426	442	6	,	,	PUNCT
gs-4426	442	7	365(8	365(8	NUM
gs-4426	442	8	)	)	PUNCT
gs-4426	442	9	,	,	PUNCT
gs-4426	442	10	725	725	NUM
gs-4426	442	11	–	–	PUNCT
gs-4426	442	12	733	733	NUM
gs-4426	442	13	.	.	X
gs-4426	443	1	32	32	NUM
gs-4426	443	2	.	.	X
gs-4426	443	3	raper	raper	NOUN
gs-4426	443	4	,	,	PUNCT
gs-4426	443	5	s.	s.	PROPN
gs-4426	443	6	e.	e.	PROPN
gs-4426	443	7	,	,	PUNCT
gs-4426	443	8	&	&	CCONJ
gs-4426	443	9	wilson	wilson	PROPN
gs-4426	443	10	,	,	PUNCT
gs-4426	443	11	j.	j.	PROPN
gs-4426	443	12	m.	m.	PROPN
gs-4426	443	13	(	(	PUNCT
gs-4426	443	14	2020	2020	NUM
gs-4426	443	15	)	)	PUNCT
gs-4426	443	16	.	.	PUNCT
gs-4426	444	1	gene	gene	NOUN
gs-4426	444	2	therapy	therapy	NOUN
gs-4426	444	3	:	:	PUNCT
gs-4426	444	4	ethical	ethical	ADJ
gs-4426	444	5	and	and	CCONJ
gs-4426	444	6	regulatory	regulatory	ADJ
gs-4426	444	7	issues	issue	NOUN
gs-4426	444	8	.	.	PUNCT
gs-4426	445	1	annual	annual	ADJ
gs-4426	445	2	review	review	NOUN
gs-4426	445	3	of	of	ADP
gs-4426	445	4	medicine	medicine	NOUN
gs-4426	445	5	,	,	PUNCT
gs-4426	445	6	71	71	NUM
gs-4426	445	7	,	,	PUNCT
gs-4426	445	8	401–415	401–415	NUM
gs-4426	445	9	.	.	PUNCT
gs-4426	446	1	33	33	NUM
gs-4426	446	2	.	.	PUNCT
gs-4426	447	1	ghongadze	ghongadze	PROPN
gs-4426	447	2	,	,	PUNCT
gs-4426	447	3	m.	m.	NOUN
gs-4426	447	4	,	,	PUNCT
gs-4426	447	5	pkhaladze	pkhaladze	NOUN
gs-4426	447	6	,	,	PUNCT
gs-4426	447	7	m.	m.	NOUN
gs-4426	447	8	,	,	PUNCT
gs-4426	447	9	sulashvili	sulashvili	NOUN
gs-4426	447	10	,	,	PUNCT
gs-4426	447	11	n.	n.	NOUN
gs-4426	447	12	,	,	PUNCT
gs-4426	447	13	&	&	CCONJ
gs-4426	447	14	pkhaladze	pkhaladze	PROPN
gs-4426	447	15	,	,	PUNCT
gs-4426	447	16	n.	n.	PROPN
gs-4426	447	17	(	(	PUNCT
gs-4426	447	18	2025	2025	NUM
gs-4426	447	19	)	)	PUNCT
gs-4426	447	20	.	.	PUNCT
gs-4426	448	1	tbilisi	tbilisi	PROPN
gs-4426	448	2	,	,	PUNCT
gs-4426	448	3	crispr	crispr	ADJ
gs-4426	448	4	/	/	SYM
gs-4426	448	5	cas9	cas9	NOUN
gs-4426	448	6	technology	technology	NOUN
gs-4426	448	7	in	in	ADP
gs-4426	448	8	cancer	cancer	NOUN
gs-4426	448	9	treatment	treatment	NOUN
gs-4426	448	10	:	:	PUNCT
gs-4426	448	11	current	current	ADJ
gs-4426	448	12	applications	application	NOUN
gs-4426	448	13	and	and	CCONJ
gs-4426	448	14	perspectives	perspective	NOUN
gs-4426	448	15	.	.	PUNCT
gs-4426	449	1	world	world	NOUN
gs-4426	449	2	of	of	ADP
gs-4426	449	3	medicine	medicine	NOUN
gs-4426	449	4	:	:	PUNCT
gs-4426	449	5	journal	journal	NOUN
gs-4426	449	6	of	of	ADP
gs-4426	449	7	biomedical	biomedical	ADJ
gs-4426	449	8	sciences	science	NOUN
gs-4426	449	9	,	,	PUNCT
gs-4426	449	10	2(2	2(2	NUM
gs-4426	449	11	)	)	PUNCT
gs-4426	449	12	,	,	PUNCT
gs-4426	449	13	71–76	71–76	NUM
gs-4426	449	14	.	.	PUNCT
gs-4426	449	15	retrieved	retrieve	VERB
gs-4426	449	16	from	from	ADP
gs-4426	449	17	https://wom.semanticjournals.org/index.php/biomed/article/view/300	https://wom.semanticjournals.org/index.php/biomed/article/view/300	PROPN
gs-4426	449	18	34	34	NUM
gs-4426	449	19	.	.	PUNCT
gs-4426	450	1	hoggatt	hoggatt	PROPN
gs-4426	450	2	,	,	PUNCT
gs-4426	450	3	j.	j.	PROPN
gs-4426	450	4	,	,	PUNCT
gs-4426	450	5	&	&	CCONJ
gs-4426	450	6	kiem	kiem	PROPN
gs-4426	450	7	,	,	PUNCT
gs-4426	450	8	h.	h.	PROPN
gs-4426	450	9	p.	p.	PROPN
gs-4426	450	10	(	(	PUNCT
gs-4426	450	11	2021	2021	NUM
gs-4426	450	12	)	)	PUNCT
gs-4426	450	13	.	.	PUNCT
gs-4426	451	1	gene	gene	NOUN
gs-4426	451	2	therapy	therapy	NOUN
gs-4426	451	3	for	for	ADP
gs-4426	451	4	inherited	inherit	VERB
gs-4426	451	5	blood	blood	NOUN
gs-4426	451	6	disorders	disorder	NOUN
gs-4426	451	7	:	:	PUNCT
gs-4426	451	8	an	an	DET
gs-4426	451	9	evolving	evolve	VERB
gs-4426	451	10	therapeutic	therapeutic	ADJ
gs-4426	451	11	paradigm	paradigm	NOUN
gs-4426	451	12	.	.	PUNCT
gs-4426	452	1	blood	blood	NOUN
gs-4426	452	2	,	,	PUNCT
gs-4426	452	3	138(22	138(22	NUM
gs-4426	452	4	)	)	PUNCT
gs-4426	452	5	,	,	PUNCT
gs-4426	452	6	2213–2222	2213–2222	NUM
gs-4426	452	7	.	.	NOUN
gs-4426	452	8	35	35	NUM
gs-4426	452	9	.	.	PUNCT
gs-4426	453	1	aphkhazava	aphkhazava	PROPN
gs-4426	453	2	,	,	PUNCT
gs-4426	453	3	d.	d.	PROPN
gs-4426	453	4	,	,	PUNCT
gs-4426	453	5	sulashvili	sulashvili	NOUN
gs-4426	453	6	,	,	PUNCT
gs-4426	453	7	n.	n.	NOUN
gs-4426	453	8	,	,	PUNCT
gs-4426	453	9	maglakelidze	maglakelidze	PROPN
gs-4426	453	10	,	,	PUNCT
gs-4426	453	11	g.	g.	PROPN
gs-4426	453	12	,	,	PUNCT
gs-4426	453	13	&	&	CCONJ
gs-4426	453	14	tkemaladze	tkemaladze	PROPN
gs-4426	453	15	,	,	PUNCT
gs-4426	453	16	j.	j.	PROPN
gs-4426	453	17	(	(	PUNCT
gs-4426	453	18	2025	2025	NUM
gs-4426	453	19	)	)	PUNCT
gs-4426	453	20	.	.	PUNCT
gs-4426	454	1	ageless	ageless	ADJ
gs-4426	454	2	creatures	creature	NOUN
gs-4426	454	3	:	:	PUNCT
gs-4426	454	4	molecular	molecular	ADJ
gs-4426	454	5	insights	insight	NOUN
gs-4426	454	6	into	into	ADP
gs-4426	454	7	organisms	organism	NOUN
gs-4426	454	8	that	that	PRON
gs-4426	454	9	defy	defy	VERB
gs-4426	454	10	aging	aging	NOUN
gs-4426	454	11	.	.	PUNCT
gs-4426	455	1	georgian	georgian	ADJ
gs-4426	455	2	scientists	scientist	NOUN
gs-4426	455	3	,	,	PUNCT
gs-4426	455	4	7(3	7(3	NUM
gs-4426	455	5	)	)	PUNCT
gs-4426	455	6	,	,	PUNCT
gs-4426	455	7	346–396	346–396	NUM
gs-4426	455	8	.	.	PUNCT
gs-4426	456	1	https://doi.org/10.52340/gs.2025.07.03.24	https://doi.org/10.52340/gs.2025.07.03.24	PRON
gs-4426	456	2	36	36	NUM
gs-4426	456	3	.	.	PUNCT
gs-4426	457	1	bhagat	bhagat	PROPN
gs-4426	457	2	,	,	PUNCT
gs-4426	457	3	m.	m.	NOUN
gs-4426	457	4	,	,	PUNCT
gs-4426	457	5	kamal	kamal	PROPN
gs-4426	457	6	,	,	PUNCT
gs-4426	457	7	r.	r.	PROPN
gs-4426	457	8	,	,	PUNCT
gs-4426	457	9	sharma	sharma	PROPN
gs-4426	457	10	,	,	PUNCT
gs-4426	457	11	j.	j.	PROPN
gs-4426	457	12	,	,	PUNCT
gs-4426	457	13	kaur	kaur	PROPN
gs-4426	457	14	,	,	PUNCT
gs-4426	457	15	k.	k.	PROPN
gs-4426	457	16	,	,	PUNCT
gs-4426	457	17	sharma	sharma	PROPN
gs-4426	457	18	,	,	PUNCT
gs-4426	457	19	a.	a.	NOUN
gs-4426	457	20	,	,	PUNCT
gs-4426	457	21	singh	singh	NOUN
gs-4426	457	22	,	,	PUNCT
gs-4426	457	23	t.	t.	PROPN
gs-4426	457	24	g.	g.	PROPN
gs-4426	457	25	,	,	PUNCT
gs-4426	457	26	bhatia	bhatia	PROPN
gs-4426	457	27	,	,	PUNCT
gs-4426	457	28	r.	r.	PROPN
gs-4426	457	29	,	,	PUNCT
gs-4426	457	30	&	&	CCONJ
gs-4426	457	31	awasthi	awasthi	PROPN
gs-4426	457	32	,	,	PUNCT
gs-4426	457	33	a.	a.	NOUN
gs-4426	457	34	(	(	PUNCT
gs-4426	457	35	2024	2024	NUM
gs-4426	457	36	)	)	PUNCT
gs-4426	457	37	.	.	PUNCT
gs-4426	458	1	gene	gene	NOUN
gs-4426	458	2	therapy	therapy	NOUN
gs-4426	458	3	:	:	PUNCT
gs-4426	458	4	towards	towards	ADP
gs-4426	458	5	a	a	DET
gs-4426	458	6	new	new	ADJ
gs-4426	458	7	era	era	NOUN
gs-4426	458	8	of	of	ADP
gs-4426	458	9	medicine	medicine	NOUN
gs-4426	458	10	.	.	PUNCT
gs-4426	459	1	aaps	aap	NOUN
gs-4426	459	2	pharmscitech	pharmscitech	VERB
gs-4426	459	3	,	,	PUNCT
gs-4426	459	4	26(1	26(1	NUM
gs-4426	459	5	)	)	PUNCT
gs-4426	459	6	,	,	PUNCT
gs-4426	459	7	17	17	NUM
gs-4426	459	8	.	.	PUNCT
gs-4426	460	1	https://doi.org/10.1208/s12249-024-03010-6	https://doi.org/10.1208/s12249-024-03010-6	NUM
gs-4426	460	2	37	37	NUM
gs-4426	460	3	.	.	PUNCT
gs-4426	461	1	zhang	zhang	PROPN
gs-4426	461	2	j	j	PROPN
gs-4426	461	3	,	,	PUNCT
gs-4426	461	4	li	li	PROPN
gs-4426	461	5	m	m	PROPN
gs-4426	461	6	,	,	PUNCT
gs-4426	461	7	liu	liu	PROPN
gs-4426	461	8	m	m	PROPN
gs-4426	461	9	,	,	PUNCT
gs-4426	461	10	yu	yu	PROPN
gs-4426	461	11	q	q	PROPN
gs-4426	461	12	,	,	PUNCT
gs-4426	461	13	ge	ge	PROPN
gs-4426	461	14	d	d	PROPN
gs-4426	461	15	,	,	PUNCT
gs-4426	461	16	zhang	zhang	PROPN
gs-4426	461	17	j.	j.	PROPN
gs-4426	461	18	metal	metal	PROPN
gs-4426	461	19	–	–	PUNCT
gs-4426	461	20	organic	organic	ADJ
gs-4426	461	21	framework	framework	NOUN
gs-4426	461	22	nanomaterials	nanomaterial	NOUN
gs-4426	461	23	as	as	ADP
gs-4426	461	24	a	a	DET
gs-4426	461	25	medicine	medicine	NOUN
gs-4426	461	26	for	for	ADP
gs-4426	461	27	catalytic	catalytic	ADJ
gs-4426	461	28	tumor	tumor	NOUN
gs-4426	461	29	therapy	therapy	NOUN
gs-4426	461	30	:	:	PUNCT
gs-4426	461	31	recent	recent	ADJ
gs-4426	461	32	advances	advance	NOUN
gs-4426	461	33	.	.	PUNCT
gs-4426	462	1	nanomaterials	nanomaterial	NOUN
gs-4426	462	2	.	.	PUNCT
gs-4426	463	1	2024;14(9):797	2024;14(9):797	NUM
gs-4426	463	2	.	.	PUNCT
gs-4426	464	1	38	38	NUM
gs-4426	464	2	.	.	PUNCT
gs-4426	465	1	belete	belete	PROPN
gs-4426	465	2	tm	tm	PROPN
gs-4426	465	3	.	.	PUNCT
gs-4426	466	1	the	the	DET
gs-4426	466	2	current	current	ADJ
gs-4426	466	3	status	status	NOUN
gs-4426	466	4	of	of	ADP
gs-4426	466	5	gene	gene	NOUN
gs-4426	466	6	therapy	therapy	NOUN
gs-4426	466	7	for	for	ADP
gs-4426	466	8	the	the	DET
gs-4426	466	9	treatment	treatment	NOUN
gs-4426	466	10	of	of	ADP
gs-4426	466	11	cancer	cancer	NOUN
gs-4426	466	12	.	.	PUNCT
gs-4426	467	1	biol	biol	PROPN
gs-4426	467	2	:	:	PUNCT
gs-4426	467	3	targets	target	VERB
gs-4426	467	4	ther	ther	ADV
gs-4426	467	5	.	.	PUNCT
gs-4426	468	1	2021;15(null):67–77	2021;15(null):67–77	NUM
gs-4426	468	2	.	.	PROPN
gs-4426	468	3	39	39	NUM
gs-4426	468	4	.	.	PUNCT
gs-4426	469	1	belete	belete	PROPN
gs-4426	469	2	tm	tm	PROPN
gs-4426	469	3	.	.	PUNCT
gs-4426	470	1	the	the	DET
gs-4426	470	2	current	current	ADJ
gs-4426	470	3	status	status	NOUN
gs-4426	470	4	of	of	ADP
gs-4426	470	5	gene	gene	NOUN
gs-4426	470	6	therapy	therapy	NOUN
gs-4426	470	7	for	for	ADP
gs-4426	470	8	the	the	DET
gs-4426	470	9	treatment	treatment	NOUN
gs-4426	470	10	of	of	ADP
gs-4426	470	11	cancer	cancer	NOUN
gs-4426	470	12	.	.	PUNCT
gs-4426	471	1	biologics	biologic	NOUN
gs-4426	471	2	.	.	PUNCT
gs-4426	472	1	2021;15:67–77	2021;15:67–77	NUM
gs-4426	472	2	.	.	PUNCT
gs-4426	473	1	40	40	NUM
gs-4426	473	2	.	.	PUNCT
gs-4426	474	1	rashid	rashid	PROPN
gs-4426	474	2	ra	ra	PROPN
gs-4426	474	3	,	,	PUNCT
gs-4426	474	4	ankathil	ankathil	PROPN
gs-4426	474	5	r.	r.	PROPN
gs-4426	474	6	gene	gene	PROPN
gs-4426	474	7	therapy	therapy	NOUN
gs-4426	474	8	:	:	PUNCT
gs-4426	474	9	an	an	DET
gs-4426	474	10	updated	update	VERB
gs-4426	474	11	overview	overview	NOUN
gs-4426	474	12	on	on	ADP
gs-4426	474	13	the	the	DET
gs-4426	474	14	promising	promising	ADJ
gs-4426	474	15	success	success	NOUN
gs-4426	474	16	stories	story	NOUN
gs-4426	474	17	.	.	PUNCT
gs-4426	475	1	malays	malays	PROPN
gs-4426	475	2	j	j	PROPN
gs-4426	475	3	pathol	pathol	NOUN
gs-4426	475	4	.	.	PUNCT
gs-4426	476	1	2020;42(2):171–85	2020;42(2):171–85	NUM
gs-4426	476	2	.	.	PUNCT
gs-4426	477	1	41	41	NUM
gs-4426	477	2	.	.	PUNCT
gs-4426	478	1	amador	amador	PROPN
gs-4426	478	2	c	c	PROPN
gs-4426	478	3	,	,	PUNCT
gs-4426	478	4	shah	shah	PROPN
gs-4426	478	5	r	r	PROPN
gs-4426	478	6	,	,	PUNCT
gs-4426	478	7	ghiam	ghiam	PROPN
gs-4426	478	8	s	s	PROPN
gs-4426	478	9	,	,	PUNCT
gs-4426	478	10	kramerov	kramerov	X
gs-4426	478	11	aa	aa	NOUN
gs-4426	478	12	,	,	PUNCT
gs-4426	478	13	ljubimov	ljubimov	PROPN
gs-4426	478	14	av	av	PROPN
gs-4426	478	15	.	.	PUNCT
gs-4426	478	16	gene	gene	NOUN
gs-4426	478	17	therapy	therapy	NOUN
gs-4426	478	18	in	in	ADP
gs-4426	478	19	the	the	DET
gs-4426	478	20	anterior	anterior	ADJ
gs-4426	478	21	eye	eye	NOUN
gs-4426	478	22	segment	segment	NOUN
gs-4426	478	23	.	.	PUNCT
gs-4426	479	1	curr	curr	PROPN
gs-4426	479	2	gene	gene	PROPN
gs-4426	479	3	ther	ther	ADV
gs-4426	479	4	.	.	PUNCT
gs-4426	480	1	2022;22(2):104–31	2022;22(2):104–31	X
gs-4426	480	2	.	.	X
gs-4426	480	3	42	42	NUM
gs-4426	480	4	.	.	PUNCT
gs-4426	481	1	alnasser	alnasser	PROPN
gs-4426	481	2	sm	sm	PROPN
gs-4426	481	3	.	.	PROPN
gs-4426	481	4	review	review	NOUN
gs-4426	481	5	on	on	ADP
gs-4426	481	6	mechanistic	mechanistic	ADJ
gs-4426	481	7	strategy	strategy	NOUN
gs-4426	481	8	of	of	ADP
gs-4426	481	9	gene	gene	NOUN
gs-4426	481	10	therapy	therapy	NOUN
gs-4426	481	11	in	in	ADP
gs-4426	481	12	the	the	DET
gs-4426	481	13	treatment	treatment	NOUN
gs-4426	481	14	of	of	ADP
gs-4426	481	15	disease	disease	NOUN
gs-4426	481	16	.	.	PUNCT
gs-4426	482	1	gene	gene	NOUN
gs-4426	482	2	.	.	PUNCT
gs-4426	483	1	2021;769:145246	2021;769:145246	X
gs-4426	483	2	.	.	PUNCT
gs-4426	484	1	43	43	NUM
gs-4426	484	2	.	.	PUNCT
gs-4426	485	1	tiwari	tiwari	PROPN
gs-4426	485	2	s	s	PROPN
gs-4426	485	3	,	,	PUNCT
gs-4426	485	4	menghani	menghani	PROPN
gs-4426	485	5	e.	e.	PROPN
gs-4426	485	6	mode	mode	PROPN
gs-4426	485	7	of	of	ADP
gs-4426	485	8	viral	viral	ADJ
gs-4426	485	9	and	and	CCONJ
gs-4426	485	10	non	non	ADJ
gs-4426	485	11	-	-	ADJ
gs-4426	485	12	viral	viral	ADJ
gs-4426	485	13	gene	gene	NOUN
gs-4426	485	14	transfer	transfer	NOUN
gs-4426	485	15	:	:	PUNCT
gs-4426	485	16	an	an	DET
gs-4426	485	17	overview	overview	NOUN
gs-4426	485	18	.	.	PUNCT
gs-4426	486	1	s.	s.	PROPN
gs-4426	486	2	tiwari	tiwari	PROPN
gs-4426	486	3	and	and	CCONJ
gs-4426	486	4	e.	e.	PROPN
gs-4426	486	5	menghani	menghani	PROPN
gs-4426	486	6	,	,	PUNCT
gs-4426	486	7	mode	mode	NOUN
gs-4426	486	8	of	of	ADP
gs-4426	486	9	viral	viral	ADJ
gs-4426	486	10	and	and	CCONJ
gs-4426	486	11	non	non	ADJ
gs-4426	486	12	-	-	ADJ
gs-4426	486	13	viral	viral	ADJ
gs-4426	486	14	gene	gene	NOUN
gs-4426	486	15	transfer	transfer	NOUN
gs-4426	486	16	:	:	PUNCT
gs-4426	486	17	an	an	DET
gs-4426	486	18	overview	overview	NOUN
gs-4426	486	19	.	.	PUNCT
gs-4426	487	1	international	international	ADJ
gs-4426	487	2	journal	journal	NOUN
gs-4426	487	3	of	of	ADP
gs-4426	487	4	advanced	advanced	ADJ
gs-4426	487	5	research	research	NOUN
gs-4426	487	6	in	in	ADP
gs-4426	487	7	engineering	engineering	NOUN
gs-4426	487	8	and	and	CCONJ
gs-4426	487	9	technology	technology	NOUN
gs-4426	487	10	.	.	PUNCT
gs-4426	488	1	2020;11(11	2020;11(11	NUM
gs-4426	488	2	)	)	PUNCT
gs-4426	488	3	.	.	PUNCT
gs-4426	489	1	44	44	NUM
gs-4426	489	2	.	.	PUNCT
gs-4426	490	1	gupta	gupta	PROPN
gs-4426	490	2	k	k	PROPN
gs-4426	490	3	,	,	PUNCT
gs-4426	490	4	singh	singh	PROPN
gs-4426	490	5	s	s	PROPN
gs-4426	490	6	,	,	PUNCT
gs-4426	490	7	garg	garg	PROPN
gs-4426	490	8	kn	kn	PROPN
gs-4426	490	9	.	.	PROPN
gs-4426	490	10	gene	gene	NOUN
gs-4426	490	11	therapy	therapy	NOUN
gs-4426	490	12	in	in	ADP
gs-4426	490	13	dentistry	dentistry	NOUN
gs-4426	490	14	:	:	PUNCT
gs-4426	490	15	tool	tool	NOUN
gs-4426	490	16	of	of	ADP
gs-4426	490	17	genetic	genetic	ADJ
gs-4426	490	18	engineering	engineering	NOUN
gs-4426	490	19	.	.	PUNCT
gs-4426	491	1	revisited	revisit	VERB
gs-4426	491	2	arch	arch	ADJ
gs-4426	491	3	oral	oral	ADJ
gs-4426	491	4	biol	biol	NOUN
gs-4426	491	5	.	.	PUNCT
gs-4426	492	1	2015;60(3):439–46	2015;60(3):439–46	X
gs-4426	492	2	.	.	PUNCT
gs-4426	493	1	45	45	NUM
gs-4426	493	2	.	.	X
gs-4426	493	3	aphkhazava	aphkhazava	PROPN
gs-4426	493	4	,	,	PUNCT
gs-4426	493	5	d.	d.	PROPN
gs-4426	493	6	,	,	PUNCT
gs-4426	493	7	sulashvili	sulashvili	NOUN
gs-4426	493	8	,	,	PUNCT
gs-4426	493	9	n.	n.	NOUN
gs-4426	493	10	,	,	PUNCT
gs-4426	493	11	egnatievi	egnatievi	PROPN
gs-4426	493	12	,	,	PUNCT
gs-4426	493	13	i.	i.	NOUN
gs-4426	493	14	,	,	PUNCT
gs-4426	493	15	tupinashvili	tupinashvili	NOUN
gs-4426	493	16	,	,	PUNCT
gs-4426	493	17	t.	t.	PROPN
gs-4426	493	18	,	,	PUNCT
gs-4426	493	19	&	&	CCONJ
gs-4426	493	20	nozadze	nozadze	NOUN
gs-4426	493	21	,	,	PUNCT
gs-4426	493	22	m.	m.	NOUN
gs-4426	493	23	(	(	PUNCT
gs-4426	493	24	2024	2024	NUM
gs-4426	493	25	)	)	PUNCT
gs-4426	493	26	.	.	PUNCT
gs-4426	494	1	dynamic	dynamic	ADJ
gs-4426	494	2	tumor	tumor	NOUN
gs-4426	494	3	microenvironment	microenvironment	NOUN
gs-4426	494	4	theory	theory	NOUN
gs-4426	494	5	:	:	PUNCT
gs-4426	494	6	a	a	DET
gs-4426	494	7	multifaceted	multifaceted	ADJ
gs-4426	494	8	approach	approach	NOUN
gs-4426	494	9	georgian	georgian	NOUN
gs-4426	494	10	scientists/	scientists/	NUM
gs-4426	494	11	.	.	PUNCT
gs-4426	495	1	7	7	NUM
gs-4426	495	2	n	n	DET
gs-4426	495	3	4	4	NUM
gs-4426	495	4	,	,	PUNCT
gs-4426	495	5	2025	2025	NUM
gs-4426	495	6	620	620	NUM
gs-4426	495	7	to	to	PART
gs-4426	495	8	tumor	tumor	NOUN
gs-4426	495	9	research	research	NOUN
gs-4426	495	10	and	and	CCONJ
gs-4426	495	11	biochemistry	biochemistry	NOUN
gs-4426	495	12	.	.	PUNCT
gs-4426	496	1	scientific	scientific	ADJ
gs-4426	496	2	journal	journal	NOUN
gs-4426	496	3	„	„	PUNCT
gs-4426	496	4	spectri	spectri	NOUN
gs-4426	496	5	“	"	PUNCT
gs-4426	496	6	,	,	PUNCT
gs-4426	496	7	9(1	9(1	NUM
gs-4426	496	8	)	)	PUNCT
gs-4426	496	9	.	.	PUNCT
gs-4426	497	1	https://doi.org/10.52340/spectri.2024.09.01.06	https://doi.org/10.52340/spectri.2024.09.01.06	ADP
gs-4426	497	2	46	46	NUM
gs-4426	497	3	.	.	PUNCT
gs-4426	498	1	dwivedi	dwivedi	PROPN
gs-4426	498	2	s	s	PROPN
gs-4426	498	3	,	,	PUNCT
gs-4426	498	4	purohit	purohit	PROPN
gs-4426	498	5	p	p	X
gs-4426	498	6	,	,	PUNCT
gs-4426	498	7	mittal	mittal	PROPN
gs-4426	498	8	y	y	PROPN
gs-4426	498	9	,	,	PUNCT
gs-4426	498	10	gupta	gupta	PROPN
gs-4426	498	11	g	g	PROPN
gs-4426	498	12	,	,	PUNCT
gs-4426	498	13	goel	goel	PROPN
gs-4426	498	14	a	a	X
gs-4426	498	15	,	,	PUNCT
gs-4426	498	16	verma	verma	PROPN
gs-4426	498	17	rc	rc	PROPN
gs-4426	498	18	,	,	PUNCT
gs-4426	498	19	khattri	khattri	PROPN
gs-4426	498	20	s	s	PROPN
gs-4426	498	21	,	,	PUNCT
gs-4426	498	22	sharma	sharma	PROPN
gs-4426	498	23	p	p	X
gs-4426	498	24	,	,	PUNCT
gs-4426	498	25	misra	misra	PROPN
gs-4426	498	26	s	s	PART
gs-4426	498	27	,	,	PUNCT
gs-4426	498	28	pant	pant	PROPN
gs-4426	498	29	kk	kk	PROPN
gs-4426	498	30	.	.	PUNCT
gs-4426	499	1	genetic	genetic	ADJ
gs-4426	499	2	engineering	engineering	NOUN
gs-4426	499	3	:	:	PUNCT
gs-4426	499	4	towards	towards	ADP
gs-4426	499	5	gene	gene	NOUN
gs-4426	499	6	therapy	therapy	NOUN
gs-4426	499	7	and	and	CCONJ
gs-4426	499	8	molecular	molecular	ADJ
gs-4426	499	9	medicine	medicine	NOUN
gs-4426	499	10	.	.	PUNCT
gs-4426	500	1	inomics	inomic	NOUN
gs-4426	500	2	technologies	technology	NOUN
gs-4426	500	3	and	and	CCONJ
gs-4426	500	4	bio	bio	NOUN
gs-4426	500	5	-	-	ADJ
gs-4426	500	6	engineering	engineering	NOUN
gs-4426	500	7	.	.	PUNCT
gs-4426	501	1	academic	academic	ADJ
gs-4426	501	2	press	press	NOUN
gs-4426	501	3	;	;	PUNCT
gs-4426	501	4	2018	2018	NUM
gs-4426	501	5	.	.	PUNCT
gs-4426	502	1	pp	pp	ADV
gs-4426	502	2	.	.	PUNCT
gs-4426	503	1	507	507	NUM
gs-4426	503	2	-	-	SYM
gs-4426	503	3	32	32	NUM
gs-4426	503	4	.	.	PUNCT
gs-4426	504	1	47	47	NUM
gs-4426	504	2	.	.	PUNCT
gs-4426	505	1	leidner	leidner	NOUN
gs-4426	505	2	r	r	PROPN
gs-4426	505	3	,	,	PUNCT
gs-4426	505	4	sanjuan	sanjuan	PROPN
gs-4426	505	5	silva	silva	PROPN
gs-4426	505	6	n	n	PROPN
gs-4426	505	7	,	,	PUNCT
gs-4426	505	8	huang	huang	PROPN
gs-4426	505	9	h	h	PROPN
gs-4426	505	10	,	,	PUNCT
gs-4426	505	11	et	et	PROPN
gs-4426	505	12	al	al	PROPN
gs-4426	505	13	.	.	PUNCT
gs-4426	506	1	neoantigen	neoantigen	PROPN
gs-4426	506	2	t	t	PROPN
gs-4426	506	3	-	-	PUNCT
gs-4426	506	4	cell	cell	NOUN
gs-4426	506	5	receptor	receptor	NOUN
gs-4426	506	6	gene	gene	NOUN
gs-4426	506	7	therapy	therapy	NOUN
gs-4426	506	8	in	in	ADP
gs-4426	506	9	pancreatic	pancreatic	ADJ
gs-4426	506	10	cancer	cancer	NOUN
gs-4426	506	11	.	.	PUNCT
gs-4426	507	1	n	n	PROPN
gs-4426	507	2	engl	engl	PROPN
gs-4426	507	3	j	j	PROPN
gs-4426	507	4	med	med	PROPN
gs-4426	507	5	.	.	PUNCT
gs-4426	508	1	2022;386(22):2112–9	2022;386(22):2112–9	X
gs-4426	508	2	.	.	PROPN
gs-4426	508	3	48	48	NUM
gs-4426	508	4	.	.	PUNCT
gs-4426	509	1	dogbey	dogbey	PROPN
gs-4426	509	2	dm	dm	PROPN
gs-4426	509	3	,	,	PUNCT
gs-4426	509	4	torres	torre	VERB
gs-4426	509	5	ves	f	NOUN
gs-4426	509	6	,	,	PUNCT
gs-4426	509	7	fajemisin	fajemisin	NOUN
gs-4426	509	8	e	e	NOUN
gs-4426	509	9	,	,	PUNCT
gs-4426	509	10	et	et	PROPN
gs-4426	509	11	al	al	PROPN
gs-4426	509	12	.	.	PUNCT
gs-4426	510	1	technological	technological	ADJ
gs-4426	510	2	advances	advance	NOUN
gs-4426	510	3	in	in	ADP
gs-4426	510	4	the	the	DET
gs-4426	510	5	use	use	NOUN
gs-4426	510	6	of	of	ADP
gs-4426	510	7	viral	viral	ADJ
gs-4426	510	8	and	and	CCONJ
gs-4426	510	9	non	non	ADJ
gs-4426	510	10	-	-	ADJ
gs-4426	510	11	viral	viral	ADJ
gs-4426	510	12	vectors	vector	NOUN
gs-4426	510	13	for	for	ADP
gs-4426	510	14	delivering	deliver	VERB
gs-4426	510	15	genetic	genetic	ADJ
gs-4426	510	16	and	and	CCONJ
gs-4426	510	17	non	non	ADJ
gs-4426	510	18	-	-	ADJ
gs-4426	510	19	genetic	genetic	ADJ
gs-4426	510	20	cargos	cargo	NOUN
gs-4426	510	21	for	for	ADP
gs-4426	510	22	cancer	cancer	NOUN
gs-4426	510	23	therapy	therapy	NOUN
gs-4426	510	24	.	.	PUNCT
gs-4426	511	1	drug	drug	PROPN
gs-4426	511	2	deliv	deliv	VERB
gs-4426	511	3	transl	transl	PROPN
gs-4426	511	4	res	re	NOUN
gs-4426	511	5	.	.	PUNCT
gs-4426	512	1	2023;13(11):2719–38	2023;13(11):2719–38	NUM
gs-4426	512	2	.	.	PUNCT
gs-4426	513	1	49	49	NUM
gs-4426	513	2	.	.	PUNCT
gs-4426	514	1	wu	wu	PROPN
gs-4426	515	1	x	x	PROPN
gs-4426	515	2	,	,	PUNCT
gs-4426	515	3	he	he	PRON
gs-4426	515	4	x	x	PROPN
gs-4426	515	5	,	,	PUNCT
gs-4426	515	6	liu	liu	PROPN
gs-4426	515	7	f	f	PROPN
gs-4426	515	8	,	,	PUNCT
gs-4426	515	9	et	et	PROPN
gs-4426	515	10	al	al	PROPN
gs-4426	515	11	.	.	PROPN
gs-4426	515	12	development	development	PROPN
gs-4426	515	13	and	and	CCONJ
gs-4426	515	14	clinical	clinical	ADJ
gs-4426	515	15	translation	translation	NOUN
gs-4426	515	16	of	of	ADP
gs-4426	515	17	ex	ex	PRON
gs-4426	515	18	vivo	vivo	ADJ
gs-4426	515	19	gene	gene	NOUN
gs-4426	515	20	therapy	therapy	NOUN
gs-4426	515	21	.	.	PUNCT
gs-4426	516	1	comput	comput	PROPN
gs-4426	516	2	struct	struct	VERB
gs-4426	516	3	biotechnol	biotechnol	NOUN
gs-4426	516	4	j.	j.	PROPN
gs-4426	516	5	2022;20:2986–3003	2022;20:2986–3003	PROPN
gs-4426	516	6	.	.	PROPN
gs-4426	517	1	50	50	NUM
gs-4426	517	2	.	.	PUNCT
gs-4426	518	1	jayarajan	jayarajan	PROPN
gs-4426	518	2	v	v	PROPN
gs-4426	518	3	,	,	PUNCT
gs-4426	518	4	kounatidou	kounatidou	ADJ
gs-4426	518	5	e	e	NOUN
gs-4426	518	6	,	,	PUNCT
gs-4426	518	7	qasim	qasim	PROPN
gs-4426	518	8	w	w	PROPN
gs-4426	518	9	,	,	PUNCT
gs-4426	518	10	di	di	PROPN
gs-4426	518	11	w	w	PROPN
gs-4426	518	12	-	-	PUNCT
gs-4426	518	13	l.	l.	NOUN
gs-4426	518	14	ex	ex	X
gs-4426	518	15	vivo	vivo	NOUN
gs-4426	518	16	gene	gene	NOUN
gs-4426	518	17	modification	modification	NOUN
gs-4426	518	18	therapy	therapy	NOUN
gs-4426	518	19	for	for	ADP
gs-4426	518	20	genetic	genetic	ADJ
gs-4426	518	21	skin	skin	NOUN
gs-4426	518	22	diseases	disease	NOUN
gs-4426	518	23	—	—	PUNCT
gs-4426	518	24	recent	recent	ADJ
gs-4426	518	25	advances	advance	NOUN
gs-4426	518	26	in	in	ADP
gs-4426	518	27	gene	gene	NOUN
gs-4426	518	28	modification	modification	NOUN
gs-4426	518	29	technologies	technology	NOUN
gs-4426	518	30	and	and	CCONJ
gs-4426	518	31	delivery	delivery	NOUN
gs-4426	518	32	.	.	PUNCT
gs-4426	519	1	exp	exp	NOUN
gs-4426	519	2	dermatol	dermatol	NOUN
gs-4426	519	3	.	.	PUNCT
gs-4426	520	1	2021;30(7):887–96	2021;30(7):887–96	NUM
gs-4426	520	2	.	.	PUNCT