id	sid	tid	token	lemma	pos
gs-4427	1	1	georgian	georgian	PROPN
gs-4427	1	2	scientists/	scientists/	NUM
gs-4427	1	3	.	.	PUNCT
gs-4427	2	1	7	7	NUM
gs-4427	2	2	n	n	DET
gs-4427	2	3	4	4	NUM
gs-4427	2	4	,	,	PUNCT
gs-4427	2	5	2025	2025	NUM
gs-4427	2	6	630	630	NUM
gs-4427	2	7	georgian	georgian	ADJ
gs-4427	2	8	scientists	scientist	NOUN
gs-4427	2	9	vol	vol	NOUN
gs-4427	2	10	.	.	PUNCT
gs-4427	2	11	7	7	NUM
gs-4427	2	12	issue	issue	NOUN
gs-4427	2	13	4	4	NUM
gs-4427	2	14	,	,	PUNCT
gs-4427	2	15	2025	2025	NUM
gs-4427	2	16	https://doi.org/10.52340/gs.2025.07.04.44	https://doi.org/10.52340/gs.2025.07.04.44	NOUN
gs-4427	2	17	advances	advance	NOUN
gs-4427	2	18	,	,	PUNCT
gs-4427	2	19	clinical	clinical	ADJ
gs-4427	2	20	translation	translation	NOUN
gs-4427	2	21	and	and	CCONJ
gs-4427	2	22	emerging	emerge	VERB
gs-4427	2	23	challenges	challenge	NOUN
gs-4427	2	24	in	in	ADP
gs-4427	2	25	gene	gene	NOUN
gs-4427	2	26	therapy	therapy	NOUN
gs-4427	2	27	:	:	PUNCT
gs-4427	2	28	from	from	ADP
gs-4427	2	29	viral	viral	ADJ
gs-4427	2	30	vector	vector	NOUN
gs-4427	2	31	engineering	engineering	NOUN
gs-4427	2	32	and	and	CCONJ
gs-4427	2	33	genome	genome	NOUN
gs-4427	2	34	editing	editing	NOUN
gs-4427	2	35	to	to	ADP
gs-4427	2	36	precision	precision	NOUN
gs-4427	2	37	and	and	CCONJ
gs-4427	2	38	personalized	personalize	VERB
gs-4427	2	39	genetic	genetic	ADJ
gs-4427	2	40	medicine	medicine	NOUN
gs-4427	2	41	nodar	nodar	PROPN
gs-4427	2	42	sulashvili1	sulashvili1	PROPN
gs-4427	2	43	,	,	PUNCT
gs-4427	2	44	igor	igor	PROPN
gs-4427	2	45	seniuk2	seniuk2	PROPN
gs-4427	2	46	,	,	PUNCT
gs-4427	2	47	vira	vira	PROPN
gs-4427	2	48	kravchenko3	kravchenko3	PROPN
gs-4427	2	49	,	,	PUNCT
gs-4427	2	50	irina	irina	PROPN
gs-4427	2	51	imerlishvili4	imerlishvili4	PROPN
gs-4427	2	52	,	,	PUNCT
gs-4427	2	53	luiza	luiza	PROPN
gs-4427	2	54	gabunia5	gabunia5	PROPN
gs-4427	2	55	,	,	PUNCT
gs-4427	2	56	nana	nana	PROPN
gs-4427	2	57	gorgaslidze6	gorgaslidze6	PROPN
gs-4427	2	58	,	,	PUNCT
gs-4427	2	59	maka	maka	PROPN
gs-4427	2	60	buleishvili7	buleishvili7	PROPN
gs-4427	2	61	,	,	PUNCT
gs-4427	2	62	marika	marika	PROPN
gs-4427	2	63	sulashvili8	sulashvili8	PROPN
gs-4427	2	64	,	,	PUNCT
gs-4427	2	65	rajkaran	rajkaran	NOUN
gs-4427	2	66	singh9	singh9	PROPN
gs-4427	2	67	,	,	PUNCT
gs-4427	2	68	deva	deva	PROPN
gs-4427	2	69	harsha	harsha	PROPN
gs-4427	2	70	uday	uday	PROPN
gs-4427	2	71	gundluru10	gundluru10	PROPN
gs-4427	2	72	,	,	PUNCT
gs-4427	2	73	david	david	PROPN
gs-4427	2	74	aphkhazava11	aphkhazava11	PROPN
gs-4427	2	75	1	1	NUM
gs-4427	2	76	.	.	PUNCT
gs-4427	3	1	md	md	PROPN
gs-4427	3	2	,	,	PUNCT
gs-4427	3	3	phd	phd	NOUN
gs-4427	3	4	,	,	PUNCT
gs-4427	3	5	doctor	doctor	NOUN
gs-4427	3	6	of	of	ADP
gs-4427	3	7	pharmaceutical	pharmaceutical	ADJ
gs-4427	3	8	and	and	CCONJ
gs-4427	3	9	pharmacological	pharmacological	ADJ
gs-4427	3	10	sciences	science	NOUN
gs-4427	3	11	in	in	ADP
gs-4427	3	12	medicine	medicine	NOUN
gs-4427	3	13	,	,	PUNCT
gs-4427	3	14	invited	invite	VERB
gs-4427	3	15	lecturer	lecturer	NOUN
gs-4427	3	16	(	(	PUNCT
gs-4427	3	17	invited	invite	VERB
gs-4427	3	18	professor	professor	NOUN
gs-4427	3	19	)	)	PUNCT
gs-4427	3	20	of	of	ADP
gs-4427	3	21	scientific	scientific	ADJ
gs-4427	3	22	research	research	NOUN
gs-4427	3	23	-	-	PUNCT
gs-4427	3	24	skills	skill	NOUN
gs-4427	3	25	center	center	NOUN
gs-4427	3	26	at	at	ADP
gs-4427	3	27	tbilisi	tbilisi	PROPN
gs-4427	3	28	state	state	PROPN
gs-4427	3	29	medical	medical	PROPN
gs-4427	3	30	university	university	PROPN
gs-4427	3	31	;	;	PUNCT
gs-4427	3	32	professor	professor	NOUN
gs-4427	3	33	of	of	ADP
gs-4427	3	34	medical	medical	ADJ
gs-4427	3	35	pharmacology	pharmacology	NOUN
gs-4427	3	36	of	of	ADP
gs-4427	3	37	faculty	faculty	NOUN
gs-4427	3	38	of	of	ADP
gs-4427	3	39	medicine	medicine	NOUN
gs-4427	3	40	at	at	ADP
gs-4427	3	41	georgian	georgian	PROPN
gs-4427	3	42	national	national	PROPN
gs-4427	3	43	university	university	PROPN
gs-4427	3	44	seu	seu	NOUN
gs-4427	3	45	;	;	PUNCT
gs-4427	3	46	professor	professor	NOUN
gs-4427	3	47	of	of	ADP
gs-4427	3	48	medical	medical	ADJ
gs-4427	3	49	and	and	CCONJ
gs-4427	3	50	clinical	clinical	ADJ
gs-4427	3	51	pharmacology	pharmacology	NOUN
gs-4427	3	52	of	of	ADP
gs-4427	3	53	international	international	ADJ
gs-4427	3	54	school	school	NOUN
gs-4427	3	55	of	of	ADP
gs-4427	3	56	medicine	medicine	NOUN
gs-4427	3	57	at	at	ADP
gs-4427	3	58	alte	alte	PROPN
gs-4427	3	59	university	university	PROPN
gs-4427	3	60	;	;	PUNCT
gs-4427	3	61	tbilisi	tbilisi	PROPN
gs-4427	3	62	,	,	PUNCT
gs-4427	3	63	georgia	georgia	PROPN
gs-4427	3	64	;	;	PUNCT
gs-4427	3	65	orcid	orcid	PROPN
gs-4427	3	66	https://orcid.org/0000-0002-9005-8577	https://orcid.org/0000-0002-9005-8577	PROPN
gs-4427	3	67	;	;	PUNCT
gs-4427	3	68	e	e	X
gs-4427	3	69	-	-	NOUN
gs-4427	3	70	mail	mail	NOUN
gs-4427	3	71	:	:	PUNCT
gs-4427	3	72	n.sulashvili@ug.edu.ge	n.sulashvili@ug.edu.ge	NOUN
gs-4427	3	73	2	2	NUM
gs-4427	3	74	.	.	PUNCT
gs-4427	3	75	phd	phd	NOUN
gs-4427	3	76	,	,	PUNCT
gs-4427	3	77	doctor	doctor	NOUN
gs-4427	3	78	of	of	ADP
gs-4427	3	79	pharmaceutical	pharmaceutical	NOUN
gs-4427	3	80	sciences	science	NOUN
gs-4427	3	81	,	,	PUNCT
gs-4427	3	82	dean	dean	NOUN
gs-4427	3	83	of	of	ADP
gs-4427	3	84	faculty	faculty	NOUN
gs-4427	3	85	of	of	ADP
gs-4427	3	86	pharmacy	pharmacy	NOUN
gs-4427	3	87	at	at	ADP
gs-4427	3	88	national	national	PROPN
gs-4427	3	89	university	university	PROPN
gs-4427	3	90	of	of	ADP
gs-4427	3	91	pharmacy	pharmacy	NOUN
gs-4427	3	92	of	of	ADP
gs-4427	3	93	ukraine	ukraine	NOUN
gs-4427	3	94	,	,	PUNCT
gs-4427	3	95	associate	associate	ADJ
gs-4427	3	96	professor	professor	NOUN
gs-4427	3	97	of	of	ADP
gs-4427	3	98	biological	biological	ADJ
gs-4427	3	99	chemistry	chemistry	NOUN
gs-4427	3	100	department	department	NOUN
gs-4427	3	101	at	at	ADP
gs-4427	3	102	national	national	PROPN
gs-4427	3	103	university	university	PROPN
gs-4427	3	104	of	of	ADP
gs-4427	3	105	pharmacy	pharmacy	NOUN
gs-4427	3	106	of	of	ADP
gs-4427	3	107	ukraine	ukraine	NOUN
gs-4427	3	108	,	,	PUNCT
gs-4427	3	109	https://orcid.org/0000-0003-3819-733	https://orcid.org/0000-0003-3819-733	PROPN
gs-4427	3	110	;	;	PUNCT
gs-4427	3	111	kharkiv	kharkiv	PROPN
gs-4427	3	112	,	,	PUNCT
gs-4427	3	113	ukraine	ukraine	NOUN
gs-4427	3	114	.	.	PUNCT
gs-4427	4	1	3	3	X
gs-4427	4	2	.	.	X
gs-4427	4	3	md	md	PROPN
gs-4427	4	4	,	,	PUNCT
gs-4427	4	5	phd	phd	PROPN
gs-4427	4	6	,	,	PUNCT
gs-4427	4	7	doctor	doctor	NOUN
gs-4427	4	8	of	of	ADP
gs-4427	4	9	biological	biological	ADJ
gs-4427	4	10	sciences	science	NOUN
gs-4427	4	11	,	,	PUNCT
gs-4427	4	12	academician	academician	NOUN
gs-4427	4	13	,	,	PUNCT
gs-4427	4	14	professor	professor	NOUN
gs-4427	4	15	,	,	PUNCT
gs-4427	4	16	head	head	NOUN
gs-4427	4	17	of	of	ADP
gs-4427	4	18	the	the	DET
gs-4427	4	19	biological	biological	ADJ
gs-4427	4	20	chemistry	chemistry	NOUN
gs-4427	4	21	department	department	NOUN
gs-4427	4	22	at	at	ADP
gs-4427	4	23	national	national	PROPN
gs-4427	4	24	university	university	PROPN
gs-4427	4	25	of	of	ADP
gs-4427	4	26	pharmacy	pharmacy	NOUN
gs-4427	4	27	of	of	ADP
gs-4427	4	28	ukraine	ukraine	NOUN
gs-4427	4	29	,	,	PUNCT
gs-4427	4	30	kharkiv	kharkiv	PROPN
gs-4427	4	31	,	,	PUNCT
gs-4427	4	32	ukraine	ukraine	NOUN
gs-4427	4	33	.	.	PUNCT
gs-4427	5	1	https://orcid.org/0000-0001-6335-2490	https://orcid.org/0000-0001-6335-2490	PROPN
gs-4427	5	2	4	4	NUM
gs-4427	5	3	.	.	X
gs-4427	5	4	phd	phd	NOUN
gs-4427	5	5	,	,	PUNCT
gs-4427	5	6	doctor	doctor	NOUN
gs-4427	5	7	of	of	ADP
gs-4427	5	8	law	law	NOUN
gs-4427	5	9	,	,	PUNCT
gs-4427	5	10	professor	professor	NOUN
gs-4427	5	11	,	,	PUNCT
gs-4427	5	12	rector	rector	NOUN
gs-4427	5	13	of	of	ADP
gs-4427	5	14	bau	bau	PROPN
gs-4427	5	15	international	international	PROPN
gs-4427	5	16	university	university	PROPN
gs-4427	5	17	batumi	batumi	NOUN
gs-4427	5	18	;	;	PUNCT
gs-4427	5	19	professor	professor	NOUN
gs-4427	5	20	of	of	ADP
gs-4427	5	21	bau	bau	PROPN
gs-4427	5	22	international	international	PROPN
gs-4427	5	23	university	university	PROPN
gs-4427	5	24	batumi	batumi	NOUN
gs-4427	5	25	;	;	PUNCT
gs-4427	5	26	professor	professor	NOUN
gs-4427	5	27	at	at	ADP
gs-4427	5	28	the	the	DET
gs-4427	5	29	international	international	ADJ
gs-4427	5	30	black	black	PROPN
gs-4427	5	31	sea	sea	PROPN
gs-4427	5	32	university	university	NOUN
gs-4427	5	33	,	,	PUNCT
gs-4427	5	34	batumi	batumi	NOUN
gs-4427	5	35	-	-	PUNCT
gs-4427	5	36	tbilisi	tbilisi	ADJ
gs-4427	5	37	,	,	PUNCT
gs-4427	5	38	georgia	georgia	PROPN
gs-4427	5	39	;	;	PUNCT
gs-4427	5	40	5	5	NUM
gs-4427	5	41	.	.	X
gs-4427	5	42	md	md	PROPN
gs-4427	5	43	,	,	PUNCT
gs-4427	5	44	phd	phd	NOUN
gs-4427	5	45	,	,	PUNCT
gs-4427	5	46	doctor	doctor	NOUN
gs-4427	5	47	of	of	ADP
gs-4427	5	48	medical	medical	ADJ
gs-4427	5	49	sciences	sciences	PROPN
gs-4427	5	50	,	,	PUNCT
gs-4427	5	51	professor	professor	NOUN
gs-4427	5	52	,	,	PUNCT
gs-4427	5	53	director	director	NOUN
gs-4427	5	54	of	of	ADP
gs-4427	5	55	the	the	DET
gs-4427	5	56	scientific	scientific	ADJ
gs-4427	5	57	research	research	NOUN
gs-4427	5	58	-	-	PUNCT
gs-4427	5	59	skills	skill	NOUN
gs-4427	5	60	center	center	NOUN
gs-4427	5	61	at	at	ADP
gs-4427	5	62	tbilisi	tbilisi	PROPN
gs-4427	5	63	state	state	PROPN
gs-4427	5	64	medical	medical	PROPN
gs-4427	5	65	university	university	PROPN
gs-4427	5	66	,	,	PUNCT
gs-4427	5	67	professor	professor	NOUN
gs-4427	5	68	,	,	PUNCT
gs-4427	5	69	head	head	NOUN
gs-4427	5	70	of	of	ADP
gs-4427	5	71	the	the	DET
gs-4427	5	72	department	department	PROPN
gs-4427	5	73	of	of	ADP
gs-4427	5	74	medical	medical	ADJ
gs-4427	5	75	and	and	CCONJ
gs-4427	5	76	clinical	clinical	ADJ
gs-4427	5	77	pharmacology	pharmacology	NOUN
gs-4427	5	78	at	at	ADP
gs-4427	5	79	tbilisi	tbilisi	PROPN
gs-4427	5	80	state	state	PROPN
gs-4427	5	81	medical	medical	PROPN
gs-4427	5	82	university	university	PROPN
gs-4427	5	83	,	,	PUNCT
gs-4427	5	84	clinical	clinical	ADJ
gs-4427	5	85	pharmacologist	pharmacologist	NOUN
gs-4427	5	86	of	of	ADP
gs-4427	5	87	the	the	DET
gs-4427	5	88	first	first	ADJ
gs-4427	5	89	university	university	NOUN
gs-4427	5	90	clinic	clinic	NOUN
gs-4427	5	91	of	of	ADP
gs-4427	5	92	tsmu	tsmu	PROPN
gs-4427	5	93	,	,	PUNCT
gs-4427	5	94	tbilisi	tbilisi	PROPN
gs-4427	5	95	,	,	PUNCT
gs-4427	5	96	georgia	georgia	PROPN
gs-4427	5	97	;	;	PUNCT
gs-4427	5	98	https://orcid.org/0000-0003-0856-2684	https://orcid.org/0000-0003-0856-2684	PROPN
gs-4427	5	99	6	6	NUM
gs-4427	5	100	.	.	PUNCT
gs-4427	5	101	md	md	PROPN
gs-4427	5	102	,	,	PUNCT
gs-4427	5	103	phd	phd	NOUN
gs-4427	5	104	,	,	PUNCT
gs-4427	5	105	doctor	doctor	NOUN
gs-4427	5	106	of	of	ADP
gs-4427	5	107	pharmaceutical	pharmaceutical	NOUN
gs-4427	5	108	sciences	science	NOUN
gs-4427	5	109	,	,	PUNCT
gs-4427	5	110	academician	academician	NOUN
gs-4427	5	111	,	,	PUNCT
gs-4427	5	112	professor	professor	NOUN
gs-4427	5	113	of	of	ADP
gs-4427	5	114	tbilisi	tbilisi	PROPN
gs-4427	5	115	state	state	PROPN
gs-4427	5	116	medical	medical	PROPN
gs-4427	5	117	university	university	PROPN
gs-4427	5	118	,	,	PUNCT
gs-4427	5	119	head	head	NOUN
gs-4427	5	120	of	of	ADP
gs-4427	5	121	the	the	DET
gs-4427	5	122	department	department	NOUN
gs-4427	5	123	of	of	ADP
gs-4427	5	124	social	social	ADJ
gs-4427	5	125	and	and	CCONJ
gs-4427	5	126	clinical	clinical	ADJ
gs-4427	5	127	pharmacy	pharmacy	NOUN
gs-4427	5	128	,	,	PUNCT
gs-4427	5	129	tbilisi	tbilisi	PROPN
gs-4427	5	130	,	,	PUNCT
gs-4427	5	131	georgia	georgia	PROPN
gs-4427	5	132	;	;	PUNCT
gs-4427	5	133	https://orcid.org/0000-0002-4563-5224	https://orcid.org/0000-0002-4563-5224	PROPN
gs-4427	5	134	7	7	NUM
gs-4427	5	135	.	.	PUNCT
gs-4427	5	136	md	md	PROPN
gs-4427	5	137	,	,	PUNCT
gs-4427	5	138	phd	phd	NOUN
gs-4427	5	139	,	,	PUNCT
gs-4427	5	140	doctor	doctor	NOUN
gs-4427	5	141	of	of	ADP
gs-4427	5	142	medical	medical	ADJ
gs-4427	5	143	sciences	sciences	PROPN
gs-4427	5	144	,	,	PUNCT
gs-4427	5	145	professor	professor	NOUN
gs-4427	5	146	,	,	PUNCT
gs-4427	5	147	dean	dean	NOUN
gs-4427	5	148	of	of	ADP
gs-4427	5	149	faculty	faculty	NOUN
gs-4427	5	150	of	of	ADP
gs-4427	5	151	medicine	medicine	NOUN
gs-4427	5	152	of	of	ADP
gs-4427	5	153	bau	bau	PROPN
gs-4427	5	154	international	international	PROPN
gs-4427	5	155	university	university	PROPN
gs-4427	5	156	batumi	batumi	NOUN
gs-4427	5	157	,	,	PUNCT
gs-4427	5	158	professor	professor	NOUN
gs-4427	5	159	of	of	ADP
gs-4427	5	160	faculty	faculty	NOUN
gs-4427	5	161	of	of	ADP
gs-4427	5	162	medicine	medicine	NOUN
gs-4427	5	163	at	at	ADP
gs-4427	5	164	european	european	PROPN
gs-4427	5	165	university	university	PROPN
gs-4427	5	166	,	,	PUNCT
gs-4427	5	167	professor	professor	NOUN
gs-4427	5	168	of	of	ADP
gs-4427	5	169	faculty	faculty	NOUN
gs-4427	5	170	of	of	ADP
gs-4427	5	171	medicine	medicine	NOUN
gs-4427	5	172	at	at	ADP
gs-4427	5	173	georgian	georgian	PROPN
gs-4427	5	174	national	national	PROPN
gs-4427	5	175	university	university	PROPN
gs-4427	5	176	seu	seu	NOUN
gs-4427	5	177	,	,	PUNCT
gs-4427	5	178	professor	professor	NOUN
gs-4427	5	179	of	of	ADP
gs-4427	5	180	faculty	faculty	NOUN
gs-4427	5	181	of	of	ADP
gs-4427	5	182	medicine	medicine	NOUN
gs-4427	5	183	at	at	ADP
gs-4427	5	184	sulkhan	sulkhan	PROPN
gs-4427	5	185	-	-	PUNCT
gs-4427	5	186	saba	saba	PROPN
gs-4427	5	187	orbeliani	orbeliani	PROPN
gs-4427	5	188	university	university	PROPN
gs-4427	5	189	,	,	PUNCT
gs-4427	5	190	invited	invite	VERB
gs-4427	5	191	professor	professor	NOUN
gs-4427	5	192	of	of	ADP
gs-4427	5	193	faculty	faculty	NOUN
gs-4427	5	194	of	of	ADP
gs-4427	5	195	healthcare	healthcare	PROPN
gs-4427	5	196	sciences	sciences	PROPN
gs-4427	5	197	at	at	ADP
gs-4427	5	198	east	east	PROPN
gs-4427	5	199	european	european	PROPN
gs-4427	5	200	university	university	PROPN
gs-4427	5	201	,	,	PUNCT
gs-4427	5	202	invited	invite	VERB
gs-4427	5	203	professor	professor	NOUN
gs-4427	5	204	of	of	ADP
gs-4427	5	205	faculty	faculty	NOUN
gs-4427	5	206	of	of	ADP
gs-4427	5	207	medicine	medicine	NOUN
gs-4427	5	208	at	at	ADP
gs-4427	5	209	caucasus	caucasus	PROPN
gs-4427	5	210	international	international	PROPN
gs-4427	5	211	university	university	PROPN
gs-4427	5	212	,	,	PUNCT
gs-4427	5	213	invited	invite	VERB
gs-4427	5	214	lecturer	lecturer	NOUN
gs-4427	5	215	of	of	ADP
gs-4427	5	216	tbilisi	tbilisi	PROPN
gs-4427	5	217	state	state	PROPN
gs-4427	5	218	medical	medical	PROPN
gs-4427	5	219	university	university	PROPN
gs-4427	5	220	,	,	PUNCT
gs-4427	5	221	tbilisi	tbilisi	PROPN
gs-4427	5	222	,	,	PUNCT
gs-4427	5	223	georgia	georgia	PROPN
gs-4427	5	224	;	;	PUNCT
gs-4427	5	225	https://orcid.org/0009-0004-2657-8473	https://orcid.org/0009-0004-2657-8473	PROPN
gs-4427	5	226	8	8	NUM
gs-4427	5	227	.	.	PUNCT
gs-4427	6	1	md	md	PROPN
gs-4427	6	2	,	,	PUNCT
gs-4427	6	3	doctor	doctor	NOUN
gs-4427	6	4	of	of	ADP
gs-4427	6	5	family	family	NOUN
gs-4427	6	6	medicine	medicine	NOUN
gs-4427	6	7	,	,	PUNCT
gs-4427	6	8	invited	invite	VERB
gs-4427	6	9	lecturer	lecturer	NOUN
gs-4427	6	10	of	of	ADP
gs-4427	6	11	tbilisi	tbilisi	PROPN
gs-4427	6	12	state	state	PROPN
gs-4427	6	13	medical	medical	PROPN
gs-4427	6	14	university	university	PROPN
gs-4427	6	15	,	,	PUNCT
gs-4427	6	16	department	department	NOUN
gs-4427	6	17	of	of	ADP
gs-4427	6	18	molecular	molecular	ADJ
gs-4427	6	19	and	and	CCONJ
gs-4427	6	20	medical	medical	ADJ
gs-4427	6	21	genetics	genetic	NOUN
gs-4427	6	22	;	;	PUNCT
gs-4427	6	23	invited	invite	VERB
gs-4427	6	24	lecturer	lecturer	NOUN
gs-4427	6	25	of	of	ADP
gs-4427	6	26	family	family	NOUN
gs-4427	6	27	medicine	medicine	NOUN
gs-4427	6	28	of	of	ADP
gs-4427	6	29	faculty	faculty	NOUN
gs-4427	6	30	of	of	ADP
gs-4427	6	31	medicine	medicine	NOUN
gs-4427	6	32	at	at	ADP
gs-4427	6	33	georgian	georgian	PROPN
gs-4427	6	34	national	national	PROPN
gs-4427	6	35	university	university	PROPN
gs-4427	6	36	seu	seu	NOUN
gs-4427	6	37	;	;	PUNCT
gs-4427	6	38	invited	invite	VERB
gs-4427	6	39	professor	professor	NOUN
gs-4427	6	40	of	of	ADP
gs-4427	6	41	biochemistry	biochemistry	NOUN
gs-4427	6	42	and	and	CCONJ
gs-4427	6	43	molecular	molecular	ADJ
gs-4427	6	44	and	and	CCONJ
gs-4427	6	45	medical	medical	ADJ
gs-4427	6	46	genetics	genetic	NOUN
gs-4427	6	47	at	at	ADP
gs-4427	6	48	the	the	DET
gs-4427	6	49	university	university	PROPN
gs-4427	6	50	of	of	ADP
gs-4427	6	51	georgia	georgia	PROPN
gs-4427	6	52	;	;	PUNCT
gs-4427	6	53	tbilisi	tbilisi	PROPN
gs-4427	6	54	,	,	PUNCT
gs-4427	6	55	georgia	georgia	PROPN
gs-4427	6	56	;	;	PUNCT
gs-4427	6	57	georgian	georgian	PROPN
gs-4427	6	58	scientists/	scientists/	NUM
gs-4427	6	59	.	.	PUNCT
gs-4427	7	1	7	7	NUM
gs-4427	7	2	n	n	DET
gs-4427	7	3	4	4	NUM
gs-4427	7	4	,	,	PUNCT
gs-4427	7	5	2025	2025	NUM
gs-4427	7	6	631	631	NUM
gs-4427	7	7	9	9	NUM
gs-4427	7	8	.	.	PUNCT
gs-4427	8	1	md	md	PROPN
gs-4427	8	2	student	student	NOUN
gs-4427	8	3	of	of	ADP
gs-4427	8	4	medical	medical	ADJ
gs-4427	8	5	doctor	doctor	NOUN
gs-4427	8	6	degree	degree	NOUN
gs-4427	8	7	program	program	NOUN
gs-4427	8	8	of	of	ADP
gs-4427	8	9	faculty	faculty	NOUN
gs-4427	8	10	of	of	ADP
gs-4427	8	11	medicine	medicine	NOUN
gs-4427	8	12	at	at	ADP
gs-4427	8	13	georgian	georgian	PROPN
gs-4427	8	14	national	national	PROPN
gs-4427	8	15	university	university	PROPN
gs-4427	8	16	seu	seu	PROPN
gs-4427	8	17	;	;	PUNCT
gs-4427	8	18	tbilisi	tbilisi	PROPN
gs-4427	8	19	,	,	PUNCT
gs-4427	8	20	georgia	georgia	PROPN
gs-4427	8	21	;	;	PUNCT
gs-4427	8	22	https://orcid.org/0009-0000-4903-0145	https://orcid.org/0009-0000-4903-0145	NOUN
gs-4427	8	23	10	10	NUM
gs-4427	8	24	.	.	PUNCT
gs-4427	9	1	md	md	PROPN
gs-4427	9	2	student	student	NOUN
gs-4427	9	3	of	of	ADP
gs-4427	9	4	medical	medical	ADJ
gs-4427	9	5	doctor	doctor	NOUN
gs-4427	9	6	degree	degree	NOUN
gs-4427	9	7	program	program	NOUN
gs-4427	9	8	of	of	ADP
gs-4427	9	9	faculty	faculty	NOUN
gs-4427	9	10	of	of	ADP
gs-4427	9	11	medicine	medicine	NOUN
gs-4427	9	12	at	at	ADP
gs-4427	9	13	university	university	PROPN
gs-4427	9	14	of	of	ADP
gs-4427	9	15	georgia	georgia	PROPN
gs-4427	9	16	,	,	PUNCT
gs-4427	9	17	tbilisi	tbilisi	PROPN
gs-4427	9	18	,	,	PUNCT
gs-4427	9	19	georgia	georgia	PROPN
gs-4427	9	20	;	;	PUNCT
gs-4427	9	21	11	11	NUM
gs-4427	9	22	.	.	X
gs-4427	10	1	phd	phd	NOUN
gs-4427	10	2	,	,	PUNCT
gs-4427	10	3	doctor	doctor	NOUN
gs-4427	10	4	of	of	ADP
gs-4427	10	5	biological	biological	ADJ
gs-4427	10	6	sciences	science	NOUN
gs-4427	10	7	,	,	PUNCT
gs-4427	10	8	invited	invite	VERB
gs-4427	10	9	professor	professor	NOUN
gs-4427	10	10	of	of	ADP
gs-4427	10	11	biochemistry	biochemistry	NOUN
gs-4427	10	12	of	of	ADP
gs-4427	10	13	university	university	PROPN
gs-4427	10	14	of	of	ADP
gs-4427	10	15	georgia	georgia	PROPN
gs-4427	10	16	,	,	PUNCT
gs-4427	10	17	tbilisi	tbilisi	PROPN
gs-4427	10	18	georgia	georgia	PROPN
gs-4427	10	19	;	;	PUNCT
gs-4427	10	20	orcid	orcid	PROPN
gs-4427	10	21	:	:	PUNCT
gs-4427	10	22	https://orcid.org/0000-0001-6216-6477	https://orcid.org/0000-0001-6216-6477	NOUN
gs-4427	10	23	abstract	abstract	NOUN
gs-4427	10	24	the	the	DET
gs-4427	10	25	advent	advent	NOUN
gs-4427	10	26	of	of	ADP
gs-4427	10	27	genome	genome	NOUN
gs-4427	10	28	editing	editing	NOUN
gs-4427	10	29	technologies	technology	NOUN
gs-4427	10	30	,	,	PUNCT
gs-4427	10	31	most	most	ADV
gs-4427	10	32	notably	notably	ADV
gs-4427	10	33	crispr	crispr	ADJ
gs-4427	10	34	-	-	PUNCT
gs-4427	10	35	cas	cas	NOUN
gs-4427	10	36	systems	system	NOUN
gs-4427	10	37	,	,	PUNCT
gs-4427	10	38	has	have	AUX
gs-4427	10	39	further	far	ADV
gs-4427	10	40	expanded	expand	VERB
gs-4427	10	41	the	the	DET
gs-4427	10	42	therapeutic	therapeutic	ADJ
gs-4427	10	43	scope	scope	NOUN
gs-4427	10	44	of	of	ADP
gs-4427	10	45	gene	gene	NOUN
gs-4427	10	46	therapy	therapy	NOUN
gs-4427	10	47	by	by	ADP
gs-4427	10	48	enabling	enable	VERB
gs-4427	10	49	precise	precise	ADJ
gs-4427	10	50	modification	modification	NOUN
gs-4427	10	51	of	of	ADP
gs-4427	10	52	endogenous	endogenous	ADJ
gs-4427	10	53	dna	dna	NOUN
gs-4427	10	54	.	.	PUNCT
gs-4427	11	1	genome	genome	NOUN
gs-4427	11	2	editing	editing	NOUN
gs-4427	11	3	allows	allow	VERB
gs-4427	11	4	direct	direct	ADJ
gs-4427	11	5	correction	correction	NOUN
gs-4427	11	6	of	of	ADP
gs-4427	11	7	pathogenic	pathogenic	ADJ
gs-4427	11	8	mutations	mutation	NOUN
gs-4427	11	9	,	,	PUNCT
gs-4427	11	10	targeted	target	VERB
gs-4427	11	11	gene	gene	NOUN
gs-4427	11	12	disruption	disruption	NOUN
gs-4427	11	13	,	,	PUNCT
gs-4427	11	14	and	and	CCONJ
gs-4427	11	15	modulation	modulation	NOUN
gs-4427	11	16	of	of	ADP
gs-4427	11	17	gene	gene	NOUN
gs-4427	11	18	expression	expression	NOUN
gs-4427	11	19	,	,	PUNCT
gs-4427	11	20	marking	mark	VERB
gs-4427	11	21	a	a	DET
gs-4427	11	22	conceptual	conceptual	ADJ
gs-4427	11	23	shift	shift	NOUN
gs-4427	11	24	from	from	ADP
gs-4427	11	25	gene	gene	NOUN
gs-4427	11	26	addition	addition	NOUN
gs-4427	11	27	toward	toward	ADP
gs-4427	11	28	permanent	permanent	ADJ
gs-4427	11	29	genetic	genetic	ADJ
gs-4427	11	30	repair	repair	NOUN
gs-4427	11	31	.	.	PUNCT
gs-4427	12	1	the	the	DET
gs-4427	12	2	clinical	clinical	ADJ
gs-4427	12	3	approval	approval	NOUN
gs-4427	12	4	of	of	ADP
gs-4427	12	5	crisprbased	crisprbase	VERB
gs-4427	12	6	therapies	therapy	NOUN
gs-4427	12	7	and	and	CCONJ
gs-4427	12	8	the	the	DET
gs-4427	12	9	rapid	rapid	ADJ
gs-4427	12	10	translation	translation	NOUN
gs-4427	12	11	of	of	ADP
gs-4427	12	12	engineered	engineer	VERB
gs-4427	12	13	t	t	PROPN
gs-4427	12	14	-	-	PUNCT
gs-4427	12	15	cell	cell	NOUN
gs-4427	12	16	therapies	therapy	NOUN
gs-4427	12	17	,	,	PUNCT
gs-4427	12	18	such	such	ADJ
gs-4427	12	19	as	as	ADP
gs-4427	12	20	chimeric	chimeric	ADJ
gs-4427	12	21	antigen	antigen	ADJ
gs-4427	12	22	receptor	receptor	NOUN
gs-4427	12	23	t	t	NOUN
gs-4427	12	24	-	-	PUNCT
gs-4427	12	25	cell	cell	NOUN
gs-4427	12	26	therapy	therapy	NOUN
gs-4427	12	27	,	,	PUNCT
gs-4427	12	28	illustrate	illustrate	VERB
gs-4427	12	29	the	the	DET
gs-4427	12	30	growing	grow	VERB
gs-4427	12	31	feasibility	feasibility	NOUN
gs-4427	12	32	and	and	CCONJ
gs-4427	12	33	impact	impact	NOUN
gs-4427	12	34	of	of	ADP
gs-4427	12	35	these	these	DET
gs-4427	12	36	approaches	approach	NOUN
gs-4427	12	37	across	across	ADP
gs-4427	12	38	oncology	oncology	NOUN
gs-4427	12	39	,	,	PUNCT
gs-4427	12	40	hematology	hematology	NOUN
gs-4427	12	41	,	,	PUNCT
gs-4427	12	42	and	and	CCONJ
gs-4427	12	43	emerging	emerge	VERB
gs-4427	12	44	non	non	ADJ
gs-4427	12	45	-	-	ADJ
gs-4427	12	46	malignant	malignant	ADJ
gs-4427	12	47	indications	indication	NOUN
gs-4427	12	48	.	.	PUNCT
gs-4427	13	1	despite	despite	SCONJ
gs-4427	13	2	remarkable	remarkable	ADJ
gs-4427	13	3	progress	progress	NOUN
gs-4427	13	4	,	,	PUNCT
gs-4427	13	5	significant	significant	ADJ
gs-4427	13	6	barriers	barrier	NOUN
gs-4427	13	7	continue	continue	VERB
gs-4427	13	8	to	to	PART
gs-4427	13	9	limit	limit	VERB
gs-4427	13	10	broader	broad	ADJ
gs-4427	13	11	implementation	implementation	NOUN
gs-4427	13	12	of	of	ADP
gs-4427	13	13	gene	gene	NOUN
gs-4427	13	14	therapy	therapy	NOUN
gs-4427	13	15	.	.	PUNCT
gs-4427	14	1	immunogenicity	immunogenicity	NOUN
gs-4427	14	2	to	to	ADP
gs-4427	14	3	viral	viral	ADJ
gs-4427	14	4	vectors	vector	NOUN
gs-4427	14	5	and	and	CCONJ
gs-4427	14	6	transgene	transgene	ADJ
gs-4427	14	7	products	product	NOUN
gs-4427	14	8	,	,	PUNCT
gs-4427	14	9	manufacturing	manufacturing	NOUN
gs-4427	14	10	complexity	complexity	NOUN
gs-4427	14	11	,	,	PUNCT
gs-4427	14	12	scalability	scalability	NOUN
gs-4427	14	13	constraints	constraint	NOUN
gs-4427	14	14	,	,	PUNCT
gs-4427	14	15	long	long	ADJ
gs-4427	14	16	-	-	PUNCT
gs-4427	14	17	term	term	NOUN
gs-4427	14	18	safety	safety	NOUN
gs-4427	14	19	monitoring	monitoring	NOUN
gs-4427	14	20	requirements	requirement	NOUN
gs-4427	14	21	,	,	PUNCT
gs-4427	14	22	and	and	CCONJ
gs-4427	14	23	unprecedented	unprecedented	ADJ
gs-4427	14	24	treatment	treatment	NOUN
gs-4427	14	25	costs	cost	NOUN
gs-4427	14	26	remain	remain	VERB
gs-4427	14	27	critical	critical	ADJ
gs-4427	14	28	challenges	challenge	NOUN
gs-4427	14	29	.	.	PUNCT
gs-4427	15	1	the	the	DET
gs-4427	15	2	economic	economic	ADJ
gs-4427	15	3	burden	burden	NOUN
gs-4427	15	4	associated	associate	VERB
gs-4427	15	5	with	with	ADP
gs-4427	15	6	gene	gene	NOUN
gs-4427	15	7	therapies	therapy	NOUN
gs-4427	15	8	necessitates	necessitate	VERB
gs-4427	15	9	innovative	innovative	ADJ
gs-4427	15	10	reimbursement	reimbursement	NOUN
gs-4427	15	11	models	model	NOUN
gs-4427	15	12	and	and	CCONJ
gs-4427	15	13	policy	policy	NOUN
gs-4427	15	14	frameworks	framework	NOUN
gs-4427	15	15	to	to	PART
gs-4427	15	16	ensure	ensure	VERB
gs-4427	15	17	sustainability	sustainability	NOUN
gs-4427	15	18	and	and	CCONJ
gs-4427	15	19	equitable	equitable	ADJ
gs-4427	15	20	access	access	NOUN
gs-4427	15	21	.	.	PUNCT
gs-4427	16	1	ethical	ethical	ADJ
gs-4427	16	2	considerations	consideration	NOUN
gs-4427	16	3	,	,	PUNCT
gs-4427	16	4	including	include	VERB
gs-4427	16	5	informed	informed	ADJ
gs-4427	16	6	consent	consent	NOUN
gs-4427	16	7	,	,	PUNCT
gs-4427	16	8	long	long	ADJ
gs-4427	16	9	-	-	PUNCT
gs-4427	16	10	term	term	NOUN
gs-4427	16	11	risk	risk	NOUN
gs-4427	16	12	assessment	assessment	NOUN
gs-4427	16	13	,	,	PUNCT
gs-4427	16	14	and	and	CCONJ
gs-4427	16	15	governance	governance	NOUN
gs-4427	16	16	of	of	ADP
gs-4427	16	17	genome	genome	NOUN
gs-4427	16	18	editing	editing	NOUN
gs-4427	16	19	technologies	technology	NOUN
gs-4427	16	20	,	,	PUNCT
gs-4427	16	21	are	be	AUX
gs-4427	16	22	increasingly	increasingly	ADV
gs-4427	16	23	central	central	ADJ
gs-4427	16	24	as	as	SCONJ
gs-4427	16	25	gene	gene	NOUN
gs-4427	16	26	therapy	therapy	NOUN
gs-4427	16	27	expands	expand	VERB
gs-4427	16	28	to	to	ADP
gs-4427	16	29	more	more	ADV
gs-4427	16	30	common	common	ADJ
gs-4427	16	31	and	and	CCONJ
gs-4427	16	32	complex	complex	ADJ
gs-4427	16	33	diseases	disease	NOUN
gs-4427	16	34	.	.	PUNCT
gs-4427	17	1	gene	gene	NOUN
gs-4427	17	2	therapy	therapy	NOUN
gs-4427	17	3	now	now	ADV
gs-4427	17	4	represents	represent	VERB
gs-4427	17	5	a	a	DET
gs-4427	17	6	diverse	diverse	ADJ
gs-4427	17	7	and	and	CCONJ
gs-4427	17	8	rapidly	rapidly	ADV
gs-4427	17	9	evolving	evolve	VERB
gs-4427	17	10	ecosystem	ecosystem	NOUN
gs-4427	17	11	of	of	ADP
gs-4427	17	12	therapeutic	therapeutic	ADJ
gs-4427	17	13	platforms	platform	NOUN
gs-4427	17	14	rather	rather	ADV
gs-4427	17	15	than	than	ADP
gs-4427	17	16	a	a	DET
gs-4427	17	17	single	single	ADJ
gs-4427	17	18	technological	technological	ADJ
gs-4427	17	19	approach	approach	NOUN
gs-4427	17	20	.	.	PUNCT
gs-4427	18	1	continued	continue	VERB
gs-4427	18	2	innovation	innovation	NOUN
gs-4427	18	3	in	in	ADP
gs-4427	18	4	delivery	delivery	NOUN
gs-4427	18	5	systems	system	NOUN
gs-4427	18	6	,	,	PUNCT
gs-4427	18	7	genome	genome	NOUN
gs-4427	18	8	editing	editing	NOUN
gs-4427	18	9	precision	precision	NOUN
gs-4427	18	10	,	,	PUNCT
gs-4427	18	11	manufacturing	manufacturing	NOUN
gs-4427	18	12	processes	process	NOUN
gs-4427	18	13	,	,	PUNCT
gs-4427	18	14	and	and	CCONJ
gs-4427	18	15	regulatory	regulatory	ADJ
gs-4427	18	16	frameworks	framework	NOUN
gs-4427	18	17	will	will	AUX
gs-4427	18	18	be	be	AUX
gs-4427	18	19	essential	essential	ADJ
gs-4427	18	20	to	to	PART
gs-4427	18	21	fully	fully	ADV
gs-4427	18	22	realize	realize	VERB
gs-4427	18	23	it	it	PRON
gs-4427	18	24	’s	’	VERB
gs-4427	18	25	potential	potential	ADJ
gs-4427	18	26	.	.	PUNCT
gs-4427	19	1	as	as	SCONJ
gs-4427	19	2	integration	integration	NOUN
gs-4427	19	3	into	into	ADP
gs-4427	19	4	routine	routine	ADJ
gs-4427	19	5	clinical	clinical	ADJ
gs-4427	19	6	practice	practice	NOUN
gs-4427	19	7	accelerates	accelerate	VERB
gs-4427	19	8	,	,	PUNCT
gs-4427	19	9	multidisciplinary	multidisciplinary	ADJ
gs-4427	19	10	collaboration	collaboration	NOUN
gs-4427	19	11	,	,	PUNCT
gs-4427	19	12	rigorous	rigorous	ADJ
gs-4427	19	13	long	long	ADJ
gs-4427	19	14	-	-	PUNCT
gs-4427	19	15	term	term	NOUN
gs-4427	19	16	surveillance	surveillance	NOUN
gs-4427	19	17	,	,	PUNCT
gs-4427	19	18	and	and	CCONJ
gs-4427	19	19	responsible	responsible	ADJ
gs-4427	19	20	ethical	ethical	ADJ
gs-4427	19	21	oversight	oversight	NOUN
gs-4427	19	22	will	will	AUX
gs-4427	19	23	be	be	AUX
gs-4427	19	24	critical	critical	ADJ
gs-4427	19	25	to	to	ADP
gs-4427	19	26	ensuring	ensure	VERB
gs-4427	19	27	that	that	SCONJ
gs-4427	19	28	gene	gene	NOUN
gs-4427	19	29	therapy	therapy	NOUN
gs-4427	19	30	fulfills	fulfill	VERB
gs-4427	19	31	its	its	PRON
gs-4427	19	32	promise	promise	NOUN
gs-4427	19	33	as	as	ADP
gs-4427	19	34	a	a	DET
gs-4427	19	35	cornerstone	cornerstone	NOUN
gs-4427	19	36	of	of	ADP
gs-4427	19	37	precision	precision	NOUN
gs-4427	19	38	and	and	CCONJ
gs-4427	19	39	personalized	personalized	ADJ
gs-4427	19	40	medicine	medicine	NOUN
gs-4427	19	41	.	.	PUNCT
gs-4427	20	1	gene	gene	NOUN
gs-4427	20	2	therapy	therapy	NOUN
gs-4427	20	3	has	have	AUX
gs-4427	20	4	emerged	emerge	VERB
gs-4427	20	5	as	as	ADP
gs-4427	20	6	a	a	DET
gs-4427	20	7	transformative	transformative	ADJ
gs-4427	20	8	paradigm	paradigm	NOUN
gs-4427	20	9	in	in	ADP
gs-4427	20	10	modern	modern	ADJ
gs-4427	20	11	biomedical	biomedical	ADJ
gs-4427	20	12	science	science	NOUN
gs-4427	20	13	,	,	PUNCT
gs-4427	20	14	fundamentally	fundamentally	ADV
gs-4427	20	15	redefining	redefine	VERB
gs-4427	20	16	approaches	approach	NOUN
gs-4427	20	17	to	to	ADP
gs-4427	20	18	disease	disease	NOUN
gs-4427	20	19	treatment	treatment	NOUN
gs-4427	20	20	by	by	ADP
gs-4427	20	21	targeting	target	VERB
gs-4427	20	22	underlying	underlie	VERB
gs-4427	20	23	genetic	genetic	ADJ
gs-4427	20	24	and	and	CCONJ
gs-4427	20	25	molecular	molecular	ADJ
gs-4427	20	26	mechanisms	mechanism	NOUN
gs-4427	20	27	rather	rather	ADV
gs-4427	20	28	than	than	ADP
gs-4427	20	29	solely	solely	ADV
gs-4427	20	30	managing	manage	VERB
gs-4427	20	31	clinical	clinical	ADJ
gs-4427	20	32	symptoms	symptom	NOUN
gs-4427	20	33	.	.	PUNCT
gs-4427	21	1	over	over	ADP
gs-4427	21	2	the	the	DET
gs-4427	21	3	past	past	ADJ
gs-4427	21	4	four	four	NUM
gs-4427	21	5	decades	decade	NOUN
gs-4427	21	6	,	,	PUNCT
gs-4427	21	7	advances	advance	NOUN
gs-4427	21	8	in	in	ADP
gs-4427	21	9	molecular	molecular	ADJ
gs-4427	21	10	biology	biology	NOUN
gs-4427	21	11	,	,	PUNCT
gs-4427	21	12	virology	virology	NOUN
gs-4427	21	13	,	,	PUNCT
gs-4427	21	14	genome	genome	NOUN
gs-4427	21	15	engineering	engineering	NOUN
gs-4427	21	16	,	,	PUNCT
gs-4427	21	17	and	and	CCONJ
gs-4427	21	18	translational	translational	ADJ
gs-4427	21	19	medicine	medicine	NOUN
gs-4427	21	20	have	have	AUX
gs-4427	21	21	driven	drive	VERB
gs-4427	21	22	the	the	DET
gs-4427	21	23	evolution	evolution	NOUN
gs-4427	21	24	of	of	ADP
gs-4427	21	25	gene	gene	NOUN
gs-4427	21	26	therapy	therapy	NOUN
gs-4427	21	27	from	from	ADP
gs-4427	21	28	an	an	DET
gs-4427	21	29	experimental	experimental	ADJ
gs-4427	21	30	concept	concept	NOUN
gs-4427	21	31	to	to	ADP
gs-4427	21	32	a	a	DET
gs-4427	21	33	clinically	clinically	ADV
gs-4427	21	34	validated	validate	VERB
gs-4427	21	35	therapeutic	therapeutic	ADJ
gs-4427	21	36	modality	modality	NOUN
gs-4427	21	37	with	with	ADP
gs-4427	21	38	multiple	multiple	ADJ
gs-4427	21	39	regulatory	regulatory	ADJ
gs-4427	21	40	approvals	approval	NOUN
gs-4427	21	41	and	and	CCONJ
gs-4427	21	42	expanding	expand	VERB
gs-4427	21	43	indications	indication	NOUN
gs-4427	21	44	.	.	PUNCT
gs-4427	22	1	this	this	DET
gs-4427	22	2	comprehensive	comprehensive	ADJ
gs-4427	22	3	review	review	NOUN
gs-4427	22	4	critically	critically	ADV
gs-4427	22	5	examines	examine	VERB
gs-4427	22	6	the	the	DET
gs-4427	22	7	scientific	scientific	ADJ
gs-4427	22	8	foundations	foundation	NOUN
gs-4427	22	9	,	,	PUNCT
gs-4427	22	10	technological	technological	ADJ
gs-4427	22	11	breakthroughs	breakthrough	NOUN
gs-4427	22	12	,	,	PUNCT
gs-4427	22	13	clinical	clinical	ADJ
gs-4427	22	14	achievements	achievement	NOUN
gs-4427	22	15	,	,	PUNCT
gs-4427	22	16	and	and	CCONJ
gs-4427	22	17	persistent	persistent	ADJ
gs-4427	22	18	challenges	challenge	NOUN
gs-4427	22	19	shaping	shape	VERB
gs-4427	22	20	the	the	DET
gs-4427	22	21	contemporary	contemporary	ADJ
gs-4427	22	22	gene	gene	NOUN
gs-4427	22	23	therapy	therapy	NOUN
gs-4427	22	24	landscape	landscape	NOUN
gs-4427	22	25	.	.	PUNCT
gs-4427	23	1	the	the	DET
gs-4427	23	2	gene	gene	NOUN
gs-4427	23	3	therapy	therapy	NOUN
gs-4427	23	4	now	now	ADV
gs-4427	23	5	represents	represent	VERB
gs-4427	23	6	a	a	DET
gs-4427	23	7	diverse	diverse	ADJ
gs-4427	23	8	and	and	CCONJ
gs-4427	23	9	rapidly	rapidly	ADV
gs-4427	23	10	evolving	evolve	VERB
gs-4427	23	11	ecosystem	ecosystem	NOUN
gs-4427	23	12	of	of	ADP
gs-4427	23	13	therapeutic	therapeutic	ADJ
gs-4427	23	14	platforms	platform	NOUN
gs-4427	23	15	rather	rather	ADV
gs-4427	23	16	than	than	ADP
gs-4427	23	17	a	a	DET
gs-4427	23	18	single	single	ADJ
gs-4427	23	19	technological	technological	ADJ
gs-4427	23	20	approach	approach	NOUN
gs-4427	23	21	.	.	PUNCT
gs-4427	24	1	continued	continue	VERB
gs-4427	24	2	georgian	georgian	NOUN
gs-4427	24	3	scientists/	scientists/	NUM
gs-4427	24	4	.	.	PUNCT
gs-4427	25	1	7	7	NUM
gs-4427	25	2	n	n	DET
gs-4427	25	3	4	4	NUM
gs-4427	25	4	,	,	PUNCT
gs-4427	25	5	2025	2025	NUM
gs-4427	25	6	632	632	NUM
gs-4427	25	7	innovation	innovation	NOUN
gs-4427	25	8	in	in	ADP
gs-4427	25	9	delivery	delivery	NOUN
gs-4427	25	10	systems	system	NOUN
gs-4427	25	11	,	,	PUNCT
gs-4427	25	12	genome	genome	NOUN
gs-4427	25	13	editing	editing	NOUN
gs-4427	25	14	precision	precision	NOUN
gs-4427	25	15	,	,	PUNCT
gs-4427	25	16	manufacturing	manufacturing	NOUN
gs-4427	25	17	processes	process	NOUN
gs-4427	25	18	,	,	PUNCT
gs-4427	25	19	and	and	CCONJ
gs-4427	25	20	regulatory	regulatory	ADJ
gs-4427	25	21	frameworks	framework	NOUN
gs-4427	25	22	will	will	AUX
gs-4427	25	23	be	be	AUX
gs-4427	25	24	essential	essential	ADJ
gs-4427	25	25	to	to	PART
gs-4427	25	26	fully	fully	ADV
gs-4427	25	27	realize	realize	VERB
gs-4427	25	28	it	it	PRON
gs-4427	25	29	’s	’	VERB
gs-4427	25	30	potential	potential	ADJ
gs-4427	25	31	.	.	PUNCT
gs-4427	26	1	as	as	SCONJ
gs-4427	26	2	integration	integration	NOUN
gs-4427	26	3	into	into	ADP
gs-4427	26	4	routine	routine	ADJ
gs-4427	26	5	clinical	clinical	ADJ
gs-4427	26	6	practice	practice	NOUN
gs-4427	26	7	accelerates	accelerate	VERB
gs-4427	26	8	,	,	PUNCT
gs-4427	26	9	multidisciplinary	multidisciplinary	ADJ
gs-4427	26	10	collaboration	collaboration	NOUN
gs-4427	26	11	,	,	PUNCT
gs-4427	26	12	rigorous	rigorous	ADJ
gs-4427	26	13	long	long	ADJ
gs-4427	26	14	-	-	PUNCT
gs-4427	26	15	term	term	NOUN
gs-4427	26	16	surveillance	surveillance	NOUN
gs-4427	26	17	,	,	PUNCT
gs-4427	26	18	and	and	CCONJ
gs-4427	26	19	responsible	responsible	ADJ
gs-4427	26	20	ethical	ethical	ADJ
gs-4427	26	21	oversight	oversight	NOUN
gs-4427	26	22	will	will	AUX
gs-4427	26	23	be	be	AUX
gs-4427	26	24	critical	critical	ADJ
gs-4427	26	25	to	to	ADP
gs-4427	26	26	ensuring	ensure	VERB
gs-4427	26	27	that	that	SCONJ
gs-4427	26	28	gene	gene	NOUN
gs-4427	26	29	therapy	therapy	NOUN
gs-4427	26	30	fulfills	fulfill	VERB
gs-4427	26	31	its	its	PRON
gs-4427	26	32	promise	promise	NOUN
gs-4427	26	33	as	as	ADP
gs-4427	26	34	a	a	DET
gs-4427	26	35	cornerstone	cornerstone	NOUN
gs-4427	26	36	of	of	ADP
gs-4427	26	37	precision	precision	NOUN
gs-4427	26	38	and	and	CCONJ
gs-4427	26	39	personalized	personalized	ADJ
gs-4427	26	40	medicine	medicine	NOUN
gs-4427	26	41	.	.	PUNCT
gs-4427	27	1	keywords	keyword	NOUN
gs-4427	27	2	:	:	PUNCT
gs-4427	27	3	gene	gene	NOUN
gs-4427	27	4	therapy	therapy	NOUN
gs-4427	27	5	,	,	PUNCT
gs-4427	27	6	viral	viral	ADJ
gs-4427	27	7	vectors	vector	NOUN
gs-4427	27	8	,	,	PUNCT
gs-4427	27	9	genome	genome	NOUN
gs-4427	27	10	editing	editing	NOUN
gs-4427	27	11	;	;	PUNCT
gs-4427	27	12	crispr	crispr	NOUN
gs-4427	27	13	-	-	PUNCT
gs-4427	27	14	cas	cas	NOUN
gs-4427	27	15	systems	system	NOUN
gs-4427	27	16	,	,	PUNCT
gs-4427	27	17	precision	precision	NOUN
gs-4427	27	18	medicine	medicine	NOUN
gs-4427	27	19	.	.	PUNCT
gs-4427	28	1	background	background	NOUN
gs-4427	28	2	gene	gene	NOUN
gs-4427	28	3	therapy	therapy	NOUN
gs-4427	28	4	has	have	AUX
gs-4427	28	5	emerged	emerge	VERB
gs-4427	28	6	as	as	ADP
gs-4427	28	7	one	one	NUM
gs-4427	28	8	of	of	ADP
gs-4427	28	9	the	the	DET
gs-4427	28	10	most	most	ADV
gs-4427	28	11	transformative	transformative	ADJ
gs-4427	28	12	innovations	innovation	NOUN
gs-4427	28	13	in	in	ADP
gs-4427	28	14	modern	modern	ADJ
gs-4427	28	15	biomedical	biomedical	ADJ
gs-4427	28	16	science	science	NOUN
gs-4427	28	17	,	,	PUNCT
gs-4427	28	18	redefining	redefine	VERB
gs-4427	28	19	the	the	DET
gs-4427	28	20	conceptual	conceptual	ADJ
gs-4427	28	21	foundations	foundation	NOUN
gs-4427	28	22	of	of	ADP
gs-4427	28	23	disease	disease	NOUN
gs-4427	28	24	treatment	treatment	NOUN
gs-4427	28	25	by	by	ADP
gs-4427	28	26	targeting	target	VERB
gs-4427	28	27	pathophysiology	pathophysiology	NOUN
gs-4427	28	28	at	at	ADP
gs-4427	28	29	the	the	DET
gs-4427	28	30	genetic	genetic	ADJ
gs-4427	28	31	and	and	CCONJ
gs-4427	28	32	molecular	molecular	ADJ
gs-4427	28	33	levels	level	NOUN
gs-4427	28	34	rather	rather	ADV
gs-4427	28	35	than	than	ADP
gs-4427	28	36	focusing	focus	VERB
gs-4427	28	37	solely	solely	ADV
gs-4427	28	38	on	on	ADP
gs-4427	28	39	symptomatic	symptomatic	ADJ
gs-4427	28	40	management	management	NOUN
gs-4427	28	41	.	.	PUNCT
gs-4427	29	1	the	the	DET
gs-4427	29	2	fundamental	fundamental	ADJ
gs-4427	29	3	premise	premise	NOUN
gs-4427	29	4	of	of	ADP
gs-4427	29	5	gene	gene	NOUN
gs-4427	29	6	therapy	therapy	NOUN
gs-4427	29	7	involves	involve	VERB
gs-4427	29	8	the	the	DET
gs-4427	29	9	deliberate	deliberate	ADJ
gs-4427	29	10	modification	modification	NOUN
gs-4427	29	11	of	of	ADP
gs-4427	29	12	genetic	genetic	ADJ
gs-4427	29	13	material	material	NOUN
gs-4427	29	14	within	within	ADP
gs-4427	29	15	a	a	DET
gs-4427	29	16	patient	patient	NOUN
gs-4427	29	17	’s	’s	PART
gs-4427	29	18	cells	cell	NOUN
gs-4427	29	19	to	to	PART
gs-4427	29	20	correct	correct	VERB
gs-4427	29	21	,	,	PUNCT
gs-4427	29	22	compensate	compensate	VERB
gs-4427	29	23	for	for	ADP
gs-4427	29	24	,	,	PUNCT
gs-4427	29	25	or	or	CCONJ
gs-4427	29	26	modulate	modulate	VERB
gs-4427	29	27	disease	disease	NOUN
gs-4427	29	28	-	-	PUNCT
gs-4427	29	29	causing	cause	VERB
gs-4427	29	30	biological	biological	ADJ
gs-4427	29	31	processes	process	NOUN
gs-4427	29	32	.	.	PUNCT
gs-4427	30	1	this	this	DET
gs-4427	30	2	paradigm	paradigm	NOUN
gs-4427	30	3	shift	shift	NOUN
gs-4427	30	4	represents	represent	VERB
gs-4427	30	5	a	a	DET
gs-4427	30	6	departure	departure	NOUN
gs-4427	30	7	from	from	ADP
gs-4427	30	8	traditional	traditional	ADJ
gs-4427	30	9	pharmacotherapy	pharmacotherapy	NOUN
gs-4427	30	10	,	,	PUNCT
gs-4427	30	11	which	which	PRON
gs-4427	30	12	typically	typically	ADV
gs-4427	30	13	requires	require	VERB
gs-4427	30	14	chronic	chronic	ADJ
gs-4427	30	15	administration	administration	NOUN
gs-4427	30	16	of	of	ADP
gs-4427	30	17	small	small	ADJ
gs-4427	30	18	-	-	PUNCT
gs-4427	30	19	molecule	molecule	NOUN
gs-4427	30	20	drugs	drug	NOUN
gs-4427	30	21	or	or	CCONJ
gs-4427	30	22	biologics	biologic	NOUN
gs-4427	30	23	to	to	PART
gs-4427	30	24	control	control	VERB
gs-4427	30	25	disease	disease	NOUN
gs-4427	30	26	manifestations	manifestation	NOUN
gs-4427	30	27	without	without	ADP
gs-4427	30	28	altering	alter	VERB
gs-4427	30	29	the	the	DET
gs-4427	30	30	underlying	underlying	ADJ
gs-4427	30	31	genetic	genetic	ADJ
gs-4427	30	32	determinants	determinant	NOUN
gs-4427	30	33	.	.	PUNCT
gs-4427	31	1	over	over	ADP
gs-4427	31	2	the	the	DET
gs-4427	31	3	past	past	ADJ
gs-4427	31	4	four	four	NUM
gs-4427	31	5	decades	decade	NOUN
gs-4427	31	6	,	,	PUNCT
gs-4427	31	7	gene	gene	NOUN
gs-4427	31	8	therapy	therapy	NOUN
gs-4427	31	9	has	have	AUX
gs-4427	31	10	evolved	evolve	VERB
gs-4427	31	11	from	from	ADP
gs-4427	31	12	a	a	DET
gs-4427	31	13	speculative	speculative	ADJ
gs-4427	31	14	experimental	experimental	ADJ
gs-4427	31	15	concept	concept	NOUN
gs-4427	31	16	into	into	ADP
gs-4427	31	17	a	a	DET
gs-4427	31	18	clinically	clinically	ADV
gs-4427	31	19	validated	validate	VERB
gs-4427	31	20	therapeutic	therapeutic	ADJ
gs-4427	31	21	strategy	strategy	NOUN
gs-4427	31	22	with	with	ADP
gs-4427	31	23	multiple	multiple	ADJ
gs-4427	31	24	regulatory	regulatory	ADJ
gs-4427	31	25	approvals	approval	NOUN
gs-4427	31	26	,	,	PUNCT
gs-4427	31	27	expanding	expand	VERB
gs-4427	31	28	indications	indication	NOUN
gs-4427	31	29	,	,	PUNCT
gs-4427	31	30	and	and	CCONJ
gs-4427	31	31	demonstrable	demonstrable	ADJ
gs-4427	31	32	long	long	ADJ
gs-4427	31	33	-	-	PUNCT
gs-4427	31	34	term	term	NOUN
gs-4427	31	35	benefits	benefit	NOUN
gs-4427	31	36	across	across	ADP
gs-4427	31	37	a	a	DET
gs-4427	31	38	growing	grow	VERB
gs-4427	31	39	range	range	NOUN
gs-4427	31	40	of	of	ADP
gs-4427	31	41	diseases	disease	NOUN
gs-4427	31	42	.	.	PUNCT
gs-4427	32	1	the	the	DET
gs-4427	32	2	origins	origin	NOUN
gs-4427	32	3	of	of	ADP
gs-4427	32	4	gene	gene	NOUN
gs-4427	32	5	therapy	therapy	NOUN
gs-4427	32	6	can	can	AUX
gs-4427	32	7	be	be	AUX
gs-4427	32	8	traced	trace	VERB
gs-4427	32	9	to	to	ADP
gs-4427	32	10	the	the	DET
gs-4427	32	11	rapid	rapid	ADJ
gs-4427	32	12	advances	advance	NOUN
gs-4427	32	13	in	in	ADP
gs-4427	32	14	molecular	molecular	ADJ
gs-4427	32	15	biology	biology	NOUN
gs-4427	32	16	and	and	CCONJ
gs-4427	32	17	recombinant	recombinant	ADJ
gs-4427	32	18	dna	dna	NOUN
gs-4427	32	19	technology	technology	NOUN
gs-4427	32	20	during	during	ADP
gs-4427	32	21	the	the	DET
gs-4427	32	22	latter	latter	ADJ
gs-4427	32	23	half	half	NOUN
gs-4427	32	24	of	of	ADP
gs-4427	32	25	the	the	DET
gs-4427	32	26	twentieth	twentieth	ADJ
gs-4427	32	27	century	century	NOUN
gs-4427	32	28	.	.	PUNCT
gs-4427	33	1	the	the	DET
gs-4427	33	2	elucidation	elucidation	NOUN
gs-4427	33	3	of	of	ADP
gs-4427	33	4	dna	dna	PROPN
gs-4427	33	5	structure	structure	NOUN
gs-4427	33	6	,	,	PUNCT
gs-4427	33	7	the	the	DET
gs-4427	33	8	genetic	genetic	ADJ
gs-4427	33	9	code	code	NOUN
gs-4427	33	10	,	,	PUNCT
gs-4427	33	11	and	and	CCONJ
gs-4427	33	12	mechanisms	mechanism	NOUN
gs-4427	33	13	of	of	ADP
gs-4427	33	14	gene	gene	NOUN
gs-4427	33	15	regulation	regulation	NOUN
gs-4427	33	16	provided	provide	VERB
gs-4427	33	17	the	the	DET
gs-4427	33	18	intellectual	intellectual	ADJ
gs-4427	33	19	framework	framework	NOUN
gs-4427	33	20	necessary	necessary	ADJ
gs-4427	33	21	to	to	PART
gs-4427	33	22	envision	envision	VERB
gs-4427	33	23	therapeutic	therapeutic	ADJ
gs-4427	33	24	gene	gene	NOUN
gs-4427	33	25	manipulation	manipulation	NOUN
gs-4427	33	26	.	.	PUNCT
gs-4427	34	1	early	early	ADJ
gs-4427	34	2	experimental	experimental	ADJ
gs-4427	34	3	work	work	NOUN
gs-4427	34	4	demonstrated	demonstrate	VERB
gs-4427	34	5	that	that	SCONJ
gs-4427	34	6	exogenous	exogenous	ADJ
gs-4427	34	7	genetic	genetic	ADJ
gs-4427	34	8	material	material	NOUN
gs-4427	34	9	could	could	AUX
gs-4427	34	10	be	be	AUX
gs-4427	34	11	introduced	introduce	VERB
gs-4427	34	12	into	into	ADP
gs-4427	34	13	mammalian	mammalian	ADJ
gs-4427	34	14	cells	cell	NOUN
gs-4427	34	15	and	and	CCONJ
gs-4427	34	16	expressed	express	VERB
gs-4427	34	17	in	in	ADP
gs-4427	34	18	a	a	DET
gs-4427	34	19	biologically	biologically	ADV
gs-4427	34	20	meaningful	meaningful	ADJ
gs-4427	34	21	manner	manner	NOUN
gs-4427	34	22	,	,	PUNCT
gs-4427	34	23	laying	lay	VERB
gs-4427	34	24	the	the	DET
gs-4427	34	25	groundwork	groundwork	NOUN
gs-4427	34	26	for	for	ADP
gs-4427	34	27	translational	translational	ADJ
gs-4427	34	28	applications	application	NOUN
gs-4427	34	29	.	.	PUNCT
gs-4427	35	1	by	by	ADP
gs-4427	35	2	the	the	DET
gs-4427	35	3	late	late	ADJ
gs-4427	35	4	1980s	1980	NOUN
gs-4427	35	5	,	,	PUNCT
gs-4427	35	6	the	the	DET
gs-4427	35	7	convergence	convergence	NOUN
gs-4427	35	8	of	of	ADP
gs-4427	35	9	virology	virology	NOUN
gs-4427	35	10	,	,	PUNCT
gs-4427	35	11	molecular	molecular	ADJ
gs-4427	35	12	genetics	genetic	NOUN
gs-4427	35	13	,	,	PUNCT
gs-4427	35	14	and	and	CCONJ
gs-4427	35	15	immunology	immunology	NOUN
gs-4427	35	16	enabled	enable	VERB
gs-4427	35	17	the	the	DET
gs-4427	35	18	first	first	ADJ
gs-4427	35	19	clinical	clinical	ADJ
gs-4427	35	20	attempts	attempt	NOUN
gs-4427	35	21	at	at	ADP
gs-4427	35	22	gene	gene	NOUN
gs-4427	35	23	transfer	transfer	NOUN
gs-4427	35	24	in	in	ADP
gs-4427	35	25	humans	human	NOUN
gs-4427	35	26	,	,	PUNCT
gs-4427	35	27	marking	mark	VERB
gs-4427	35	28	the	the	DET
gs-4427	35	29	beginning	beginning	NOUN
gs-4427	35	30	of	of	ADP
gs-4427	35	31	a	a	DET
gs-4427	35	32	new	new	ADJ
gs-4427	35	33	era	era	NOUN
gs-4427	35	34	in	in	ADP
gs-4427	35	35	experimental	experimental	ADJ
gs-4427	35	36	medicine	medicine	NOUN
gs-4427	35	37	.	.	PUNCT
gs-4427	36	1	the	the	DET
gs-4427	36	2	initial	initial	ADJ
gs-4427	36	3	phase	phase	NOUN
gs-4427	36	4	of	of	ADP
gs-4427	36	5	gene	gene	NOUN
gs-4427	36	6	therapy	therapy	NOUN
gs-4427	36	7	development	development	NOUN
gs-4427	36	8	was	be	AUX
gs-4427	36	9	characterized	characterize	VERB
gs-4427	36	10	by	by	ADP
gs-4427	36	11	cautious	cautious	ADJ
gs-4427	36	12	optimism	optimism	NOUN
gs-4427	36	13	,	,	PUNCT
gs-4427	36	14	tempered	temper	VERB
gs-4427	36	15	by	by	ADP
gs-4427	36	16	limited	limited	ADJ
gs-4427	36	17	efficacy	efficacy	NOUN
gs-4427	36	18	and	and	CCONJ
gs-4427	36	19	significant	significant	ADJ
gs-4427	36	20	safety	safety	NOUN
gs-4427	36	21	concerns	concern	NOUN
gs-4427	36	22	.	.	PUNCT
gs-4427	37	1	early	early	ADJ
gs-4427	37	2	clinical	clinical	ADJ
gs-4427	37	3	trials	trial	NOUN
gs-4427	37	4	primarily	primarily	ADV
gs-4427	37	5	focused	focus	VERB
gs-4427	37	6	on	on	ADP
gs-4427	37	7	monogenic	monogenic	ADJ
gs-4427	37	8	disorders	disorder	NOUN
gs-4427	37	9	,	,	PUNCT
gs-4427	37	10	where	where	SCONJ
gs-4427	37	11	replacement	replacement	NOUN
gs-4427	37	12	of	of	ADP
gs-4427	37	13	a	a	DET
gs-4427	37	14	single	single	ADJ
gs-4427	37	15	defective	defective	ADJ
gs-4427	37	16	gene	gene	NOUN
gs-4427	37	17	offered	offer	VERB
gs-4427	37	18	a	a	DET
gs-4427	37	19	theoretically	theoretically	ADV
gs-4427	37	20	straightforward	straightforward	ADJ
gs-4427	37	21	therapeutic	therapeutic	ADJ
gs-4427	37	22	approach	approach	NOUN
gs-4427	37	23	.	.	PUNCT
gs-4427	38	1	however	however	ADV
gs-4427	38	2	,	,	PUNCT
gs-4427	38	3	these	these	DET
gs-4427	38	4	studies	study	NOUN
gs-4427	38	5	revealed	reveal	VERB
gs-4427	38	6	substantial	substantial	ADJ
gs-4427	38	7	challenges	challenge	NOUN
gs-4427	38	8	related	relate	VERB
gs-4427	38	9	to	to	ADP
gs-4427	38	10	inefficient	inefficient	ADJ
gs-4427	38	11	gene	gene	NOUN
gs-4427	38	12	delivery	delivery	NOUN
gs-4427	38	13	,	,	PUNCT
gs-4427	38	14	transient	transient	ADJ
gs-4427	38	15	expression	expression	NOUN
gs-4427	38	16	,	,	PUNCT
gs-4427	38	17	immune	immune	ADJ
gs-4427	38	18	responses	response	NOUN
gs-4427	38	19	to	to	ADP
gs-4427	38	20	viral	viral	ADJ
gs-4427	38	21	vectors	vector	NOUN
gs-4427	38	22	,	,	PUNCT
gs-4427	38	23	and	and	CCONJ
gs-4427	38	24	unintended	unintended	ADJ
gs-4427	38	25	genomic	genomic	ADJ
gs-4427	38	26	effects	effect	NOUN
gs-4427	38	27	.	.	PUNCT
gs-4427	39	1	high	high	ADJ
gs-4427	39	2	-	-	PUNCT
gs-4427	39	3	profile	profile	NOUN
gs-4427	39	4	adverse	adverse	ADJ
gs-4427	39	5	events	event	NOUN
gs-4427	39	6	underscored	underscore	VERB
gs-4427	39	7	the	the	DET
gs-4427	39	8	risks	risk	NOUN
gs-4427	39	9	associated	associate	VERB
gs-4427	39	10	with	with	ADP
gs-4427	39	11	early	early	ADJ
gs-4427	39	12	-	-	PUNCT
gs-4427	39	13	generation	generation	NOUN
gs-4427	39	14	vectors	vector	NOUN
gs-4427	39	15	and	and	CCONJ
gs-4427	39	16	highlighted	highlight	VERB
gs-4427	39	17	the	the	DET
gs-4427	39	18	need	need	NOUN
gs-4427	39	19	for	for	ADP
gs-4427	39	20	more	more	ADV
gs-4427	39	21	sophisticated	sophisticated	ADJ
gs-4427	39	22	delivery	delivery	NOUN
gs-4427	39	23	systems	system	NOUN
gs-4427	39	24	,	,	PUNCT
gs-4427	39	25	rigorous	rigorous	ADJ
gs-4427	39	26	regulatory	regulatory	ADJ
gs-4427	39	27	oversight	oversight	NOUN
gs-4427	39	28	,	,	PUNCT
gs-4427	39	29	and	and	CCONJ
gs-4427	39	30	a	a	DET
gs-4427	39	31	deeper	deep	ADJ
gs-4427	39	32	understanding	understanding	NOUN
gs-4427	39	33	of	of	ADP
gs-4427	39	34	host	host	NOUN
gs-4427	39	35	–	–	PUNCT
gs-4427	39	36	vector	vector	NOUN
gs-4427	39	37	interactions	interaction	NOUN
gs-4427	39	38	.	.	PUNCT
gs-4427	40	1	these	these	DET
gs-4427	40	2	setbacks	setback	NOUN
gs-4427	40	3	,	,	PUNCT
gs-4427	40	4	while	while	SCONJ
gs-4427	40	5	slowing	slow	VERB
gs-4427	40	6	clinical	clinical	ADJ
gs-4427	40	7	progress	progress	NOUN
gs-4427	40	8	,	,	PUNCT
gs-4427	40	9	catalyzed	catalyze	VERB
gs-4427	40	10	critical	critical	ADJ
gs-4427	40	11	scientific	scientific	ADJ
gs-4427	40	12	and	and	CCONJ
gs-4427	40	13	regulatory	regulatory	ADJ
gs-4427	40	14	reforms	reform	NOUN
gs-4427	40	15	that	that	PRON
gs-4427	40	16	ultimately	ultimately	ADV
gs-4427	40	17	strengthened	strengthen	VERB
gs-4427	40	18	the	the	DET
gs-4427	40	19	field	field	NOUN
gs-4427	40	20	.	.	PUNCT
gs-4427	41	1	georgian	georgian	NOUN
gs-4427	41	2	scientists/	scientists/	NUM
gs-4427	41	3	.	.	PUNCT
gs-4427	42	1	7	7	NUM
gs-4427	42	2	n	n	PRON
gs-4427	42	3	4	4	NUM
gs-4427	42	4	,	,	PUNCT
gs-4427	42	5	2025	2025	NUM
gs-4427	42	6	633	633	NUM
gs-4427	42	7	a	a	DET
gs-4427	42	8	pivotal	pivotal	ADJ
gs-4427	42	9	turning	turning	NOUN
gs-4427	42	10	point	point	NOUN
gs-4427	42	11	in	in	ADP
gs-4427	42	12	gene	gene	NOUN
gs-4427	42	13	therapy	therapy	NOUN
gs-4427	42	14	occurred	occur	VERB
gs-4427	42	15	with	with	ADP
gs-4427	42	16	the	the	DET
gs-4427	42	17	refinement	refinement	NOUN
gs-4427	42	18	of	of	ADP
gs-4427	42	19	viral	viral	ADJ
gs-4427	42	20	vector	vector	NOUN
gs-4427	42	21	technologies	technology	NOUN
gs-4427	42	22	,	,	PUNCT
gs-4427	42	23	particularly	particularly	ADV
gs-4427	42	24	adeno	adeno	NOUN
gs-4427	42	25	-	-	PUNCT
gs-4427	42	26	associated	associate	VERB
gs-4427	42	27	virus	virus	NOUN
gs-4427	42	28	and	and	CCONJ
gs-4427	42	29	lentiviral	lentiviral	ADJ
gs-4427	42	30	systems	system	NOUN
gs-4427	42	31	.	.	PUNCT
gs-4427	43	1	adeno	adeno	NOUN
gs-4427	43	2	-	-	PUNCT
gs-4427	43	3	associated	associate	VERB
gs-4427	43	4	virus	virus	NOUN
gs-4427	43	5	vectors	vector	NOUN
gs-4427	43	6	demonstrated	demonstrate	VERB
gs-4427	43	7	favorable	favorable	ADJ
gs-4427	43	8	safety	safety	NOUN
gs-4427	43	9	profiles	profile	NOUN
gs-4427	43	10	,	,	PUNCT
gs-4427	43	11	low	low	ADJ
gs-4427	43	12	pathogenicity	pathogenicity	NOUN
gs-4427	43	13	,	,	PUNCT
gs-4427	43	14	and	and	CCONJ
gs-4427	43	15	the	the	DET
gs-4427	43	16	capacity	capacity	NOUN
gs-4427	43	17	for	for	ADP
gs-4427	43	18	sustained	sustained	ADJ
gs-4427	43	19	gene	gene	NOUN
gs-4427	43	20	expression	expression	NOUN
gs-4427	43	21	in	in	ADP
gs-4427	43	22	non	non	ADJ
gs-4427	43	23	-	-	ADJ
gs-4427	43	24	dividing	dividing	ADJ
gs-4427	43	25	cells	cell	NOUN
gs-4427	43	26	,	,	PUNCT
gs-4427	43	27	making	make	VERB
gs-4427	43	28	them	they	PRON
gs-4427	43	29	particularly	particularly	ADV
gs-4427	43	30	suitable	suitable	ADJ
gs-4427	43	31	for	for	ADP
gs-4427	43	32	in	in	ADP
gs-4427	43	33	vivo	vivo	ADJ
gs-4427	43	34	applications	application	NOUN
gs-4427	43	35	targeting	target	VERB
gs-4427	43	36	organs	organ	NOUN
gs-4427	43	37	such	such	ADJ
gs-4427	43	38	as	as	ADP
gs-4427	43	39	the	the	DET
gs-4427	43	40	liver	liver	NOUN
gs-4427	43	41	,	,	PUNCT
gs-4427	43	42	retina	retina	NOUN
gs-4427	43	43	,	,	PUNCT
gs-4427	43	44	muscle	muscle	NOUN
gs-4427	43	45	,	,	PUNCT
gs-4427	43	46	and	and	CCONJ
gs-4427	43	47	central	central	ADJ
gs-4427	43	48	nervous	nervous	ADJ
gs-4427	43	49	system	system	NOUN
gs-4427	43	50	.	.	PUNCT
gs-4427	44	1	in	in	ADP
gs-4427	44	2	parallel	parallel	NOUN
gs-4427	44	3	,	,	PUNCT
gs-4427	44	4	lentiviral	lentiviral	ADJ
gs-4427	44	5	vectors	vector	NOUN
gs-4427	44	6	enabled	enable	VERB
gs-4427	44	7	stable	stable	ADJ
gs-4427	44	8	genomic	genomic	NOUN
gs-4427	44	9	integration	integration	NOUN
gs-4427	44	10	in	in	ADP
gs-4427	44	11	dividing	divide	VERB
gs-4427	44	12	cells	cell	NOUN
gs-4427	44	13	,	,	PUNCT
gs-4427	44	14	facilitating	facilitate	VERB
gs-4427	44	15	ex	ex	PRON
gs-4427	44	16	vivo	vivo	NOUN
gs-4427	44	17	modification	modification	NOUN
gs-4427	44	18	of	of	ADP
gs-4427	44	19	hematopoietic	hematopoietic	ADJ
gs-4427	44	20	stem	stem	NOUN
gs-4427	44	21	cells	cell	NOUN
gs-4427	44	22	and	and	CCONJ
gs-4427	44	23	immune	immune	ADJ
gs-4427	44	24	cells	cell	NOUN
gs-4427	44	25	.	.	PUNCT
gs-4427	45	1	these	these	DET
gs-4427	45	2	technological	technological	ADJ
gs-4427	45	3	advances	advance	NOUN
gs-4427	45	4	addressed	address	VERB
gs-4427	45	5	many	many	ADJ
gs-4427	45	6	of	of	ADP
gs-4427	45	7	the	the	DET
gs-4427	45	8	limitations	limitation	NOUN
gs-4427	45	9	encountered	encounter	VERB
gs-4427	45	10	in	in	ADP
gs-4427	45	11	early	early	ADJ
gs-4427	45	12	trials	trial	NOUN
gs-4427	45	13	and	and	CCONJ
gs-4427	45	14	provided	provide	VERB
gs-4427	45	15	reliable	reliable	ADJ
gs-4427	45	16	platforms	platform	NOUN
gs-4427	45	17	for	for	ADP
gs-4427	45	18	clinical	clinical	ADJ
gs-4427	45	19	translation	translation	NOUN
gs-4427	45	20	.	.	PUNCT
gs-4427	46	1	the	the	DET
gs-4427	46	2	maturation	maturation	NOUN
gs-4427	46	3	of	of	ADP
gs-4427	46	4	vector	vector	NOUN
gs-4427	46	5	technology	technology	NOUN
gs-4427	46	6	coincided	coincide	VERB
gs-4427	46	7	with	with	ADP
gs-4427	46	8	significant	significant	ADJ
gs-4427	46	9	progress	progress	NOUN
gs-4427	46	10	in	in	ADP
gs-4427	46	11	manufacturing	manufacture	VERB
gs-4427	46	12	science	science	NOUN
gs-4427	46	13	and	and	CCONJ
gs-4427	46	14	regulatory	regulatory	ADJ
gs-4427	46	15	frameworks	framework	NOUN
gs-4427	46	16	.	.	PUNCT
gs-4427	47	1	the	the	DET
gs-4427	47	2	establishment	establishment	NOUN
gs-4427	47	3	of	of	ADP
gs-4427	47	4	good	good	ADJ
gs-4427	47	5	manufacturing	manufacturing	NOUN
gs-4427	47	6	practice	practice	NOUN
gs-4427	47	7	standards	standard	NOUN
gs-4427	47	8	for	for	ADP
gs-4427	47	9	gene	gene	NOUN
gs-4427	47	10	therapy	therapy	NOUN
gs-4427	47	11	products	product	NOUN
gs-4427	47	12	ensured	ensure	VERB
gs-4427	47	13	consistency	consistency	NOUN
gs-4427	47	14	,	,	PUNCT
gs-4427	47	15	safety	safety	NOUN
gs-4427	47	16	,	,	PUNCT
gs-4427	47	17	and	and	CCONJ
gs-4427	47	18	quality	quality	NOUN
gs-4427	47	19	across	across	ADP
gs-4427	47	20	clinical	clinical	ADJ
gs-4427	47	21	programs	program	NOUN
gs-4427	47	22	.	.	PUNCT
gs-4427	48	1	regulatory	regulatory	ADJ
gs-4427	48	2	agencies	agency	NOUN
gs-4427	48	3	developed	develop	VERB
gs-4427	48	4	specialized	specialized	ADJ
gs-4427	48	5	guidelines	guideline	NOUN
gs-4427	48	6	recognizing	recognize	VERB
gs-4427	48	7	the	the	DET
gs-4427	48	8	unique	unique	ADJ
gs-4427	48	9	characteristics	characteristic	NOUN
gs-4427	48	10	of	of	ADP
gs-4427	48	11	gene	gene	NOUN
gs-4427	48	12	and	and	CCONJ
gs-4427	48	13	cell	cell	NOUN
gs-4427	48	14	therapies	therapy	NOUN
gs-4427	48	15	,	,	PUNCT
gs-4427	48	16	including	include	VERB
gs-4427	48	17	long	long	ADJ
gs-4427	48	18	-	-	PUNCT
gs-4427	48	19	term	term	NOUN
gs-4427	48	20	follow	follow	NOUN
gs-4427	48	21	-	-	PUNCT
gs-4427	48	22	up	up	ADP
gs-4427	48	23	requirements	requirement	NOUN
gs-4427	48	24	and	and	CCONJ
gs-4427	48	25	adaptive	adaptive	ADJ
gs-4427	48	26	approval	approval	NOUN
gs-4427	48	27	pathways	pathway	NOUN
gs-4427	48	28	for	for	ADP
gs-4427	48	29	rare	rare	ADJ
gs-4427	48	30	and	and	CCONJ
gs-4427	48	31	life	life	NOUN
gs-4427	48	32	-	-	PUNCT
gs-4427	48	33	threatening	threaten	VERB
gs-4427	48	34	conditions	condition	NOUN
gs-4427	48	35	.	.	PUNCT
gs-4427	49	1	these	these	DET
gs-4427	49	2	developments	development	NOUN
gs-4427	49	3	created	create	VERB
gs-4427	49	4	an	an	DET
gs-4427	49	5	environment	environment	NOUN
gs-4427	49	6	conducive	conducive	ADJ
gs-4427	49	7	to	to	ADP
gs-4427	49	8	innovation	innovation	NOUN
gs-4427	49	9	while	while	SCONJ
gs-4427	49	10	maintaining	maintain	VERB
gs-4427	49	11	patient	patient	ADJ
gs-4427	49	12	safety	safety	NOUN
gs-4427	49	13	,	,	PUNCT
gs-4427	49	14	enabling	enable	VERB
gs-4427	49	15	the	the	DET
gs-4427	49	16	first	first	ADJ
gs-4427	49	17	wave	wave	NOUN
gs-4427	49	18	of	of	ADP
gs-4427	49	19	regulatory	regulatory	ADJ
gs-4427	49	20	approvals	approval	NOUN
gs-4427	49	21	that	that	PRON
gs-4427	49	22	validated	validate	VERB
gs-4427	49	23	gene	gene	NOUN
gs-4427	49	24	therapy	therapy	NOUN
gs-4427	49	25	as	as	ADP
gs-4427	49	26	a	a	DET
gs-4427	49	27	legitimate	legitimate	ADJ
gs-4427	49	28	clinical	clinical	ADJ
gs-4427	49	29	modality	modality	NOUN
gs-4427	49	30	.	.	PUNCT
gs-4427	50	1	the	the	DET
gs-4427	50	2	approval	approval	NOUN
gs-4427	50	3	of	of	ADP
gs-4427	50	4	in	in	ADP
gs-4427	50	5	vivo	vivo	ADJ
gs-4427	50	6	gene	gene	NOUN
gs-4427	50	7	therapies	therapy	NOUN
gs-4427	50	8	for	for	ADP
gs-4427	50	9	inherited	inherit	VERB
gs-4427	50	10	retinal	retinal	ADJ
gs-4427	50	11	dystrophies	dystrophy	NOUN
gs-4427	50	12	and	and	CCONJ
gs-4427	50	13	neuromuscular	neuromuscular	ADJ
gs-4427	50	14	disorders	disorder	NOUN
gs-4427	50	15	marked	mark	VERB
gs-4427	50	16	a	a	DET
gs-4427	50	17	milestone	milestone	NOUN
gs-4427	50	18	in	in	ADP
gs-4427	50	19	the	the	DET
gs-4427	50	20	field	field	NOUN
gs-4427	50	21	,	,	PUNCT
gs-4427	50	22	demonstrating	demonstrate	VERB
gs-4427	50	23	that	that	SCONJ
gs-4427	50	24	single	single	ADJ
gs-4427	50	25	-	-	PUNCT
gs-4427	50	26	administration	administration	NOUN
gs-4427	50	27	genetic	genetic	ADJ
gs-4427	50	28	interventions	intervention	NOUN
gs-4427	50	29	could	could	AUX
gs-4427	50	30	produce	produce	VERB
gs-4427	50	31	durable	durable	ADJ
gs-4427	50	32	functional	functional	ADJ
gs-4427	50	33	improvements	improvement	NOUN
gs-4427	50	34	.	.	PUNCT
gs-4427	51	1	these	these	DET
gs-4427	51	2	successes	success	NOUN
gs-4427	51	3	provided	provide	VERB
gs-4427	51	4	proof	proof	NOUN
gs-4427	51	5	that	that	SCONJ
gs-4427	51	6	targeted	target	VERB
gs-4427	51	7	gene	gene	NOUN
gs-4427	51	8	delivery	delivery	NOUN
gs-4427	51	9	could	could	AUX
gs-4427	51	10	restore	restore	VERB
gs-4427	51	11	or	or	CCONJ
gs-4427	51	12	compensate	compensate	VERB
gs-4427	51	13	for	for	ADP
gs-4427	51	14	lost	lose	VERB
gs-4427	51	15	biological	biological	ADJ
gs-4427	51	16	functions	function	NOUN
gs-4427	51	17	in	in	ADP
gs-4427	51	18	human	human	ADJ
gs-4427	51	19	tissues	tissue	NOUN
gs-4427	51	20	.	.	PUNCT
gs-4427	52	1	similarly	similarly	ADV
gs-4427	52	2	,	,	PUNCT
gs-4427	52	3	ex	ex	X
gs-4427	52	4	vivo	vivo	NOUN
gs-4427	52	5	gene	gene	NOUN
gs-4427	52	6	therapy	therapy	NOUN
gs-4427	52	7	approaches	approach	VERB
gs-4427	52	8	for	for	ADP
gs-4427	52	9	inherited	inherit	VERB
gs-4427	52	10	blood	blood	NOUN
gs-4427	52	11	disorders	disorder	NOUN
gs-4427	52	12	established	establish	VERB
gs-4427	52	13	that	that	SCONJ
gs-4427	52	14	autologous	autologous	ADJ
gs-4427	52	15	genetically	genetically	ADV
gs-4427	52	16	modified	modify	VERB
gs-4427	52	17	cells	cell	NOUN
gs-4427	52	18	could	could	AUX
gs-4427	52	19	engraft	engraft	VERB
gs-4427	52	20	,	,	PUNCT
gs-4427	52	21	persist	persist	NOUN
gs-4427	52	22	,	,	PUNCT
gs-4427	52	23	and	and	CCONJ
gs-4427	52	24	confer	confer	VERB
gs-4427	52	25	long	long	ADJ
gs-4427	52	26	-	-	PUNCT
gs-4427	52	27	term	term	NOUN
gs-4427	52	28	clinical	clinical	ADJ
gs-4427	52	29	benefit	benefit	NOUN
gs-4427	52	30	.	.	PUNCT
gs-4427	53	1	collectively	collectively	ADV
gs-4427	53	2	,	,	PUNCT
gs-4427	53	3	these	these	DET
gs-4427	53	4	achievements	achievement	NOUN
gs-4427	53	5	transformed	transform	VERB
gs-4427	53	6	gene	gene	NOUN
gs-4427	53	7	therapy	therapy	NOUN
gs-4427	53	8	from	from	ADP
gs-4427	53	9	a	a	DET
gs-4427	53	10	niche	niche	NOUN
gs-4427	53	11	experimental	experimental	ADJ
gs-4427	53	12	strategy	strategy	NOUN
gs-4427	53	13	into	into	ADP
gs-4427	53	14	a	a	DET
gs-4427	53	15	cornerstone	cornerstone	NOUN
gs-4427	53	16	of	of	ADP
gs-4427	53	17	precision	precision	NOUN
gs-4427	53	18	medicine	medicine	NOUN
gs-4427	53	19	.	.	PUNCT
gs-4427	54	1	a	a	DET
gs-4427	54	2	further	further	ADJ
gs-4427	54	3	acceleration	acceleration	NOUN
gs-4427	54	4	in	in	ADP
gs-4427	54	5	the	the	DET
gs-4427	54	6	field	field	NOUN
gs-4427	54	7	was	be	AUX
gs-4427	54	8	driven	drive	VERB
gs-4427	54	9	by	by	ADP
gs-4427	54	10	the	the	DET
gs-4427	54	11	advent	advent	NOUN
gs-4427	54	12	of	of	ADP
gs-4427	54	13	genome	genome	NOUN
gs-4427	54	14	editing	editing	NOUN
gs-4427	54	15	technologies	technology	NOUN
gs-4427	54	16	,	,	PUNCT
gs-4427	54	17	most	most	ADV
gs-4427	54	18	notably	notably	ADV
gs-4427	54	19	crispr	crispr	ADJ
gs-4427	54	20	-	-	PUNCT
gs-4427	54	21	cas	cas	NOUN
gs-4427	54	22	systems	system	NOUN
gs-4427	54	23	.	.	PUNCT
gs-4427	55	1	unlike	unlike	ADP
gs-4427	55	2	traditional	traditional	ADJ
gs-4427	55	3	gene	gene	NOUN
gs-4427	55	4	addition	addition	NOUN
gs-4427	55	5	approaches	approach	NOUN
gs-4427	55	6	,	,	PUNCT
gs-4427	55	7	genome	genome	NOUN
gs-4427	55	8	editing	editing	NOUN
gs-4427	55	9	enables	enable	VERB
gs-4427	55	10	precise	precise	ADJ
gs-4427	55	11	modification	modification	NOUN
gs-4427	55	12	of	of	ADP
gs-4427	55	13	endogenous	endogenous	ADJ
gs-4427	55	14	dna	dna	PROPN
gs-4427	55	15	sequences	sequence	NOUN
gs-4427	55	16	,	,	PUNCT
gs-4427	55	17	allowing	allow	VERB
gs-4427	55	18	direct	direct	ADJ
gs-4427	55	19	correction	correction	NOUN
gs-4427	55	20	of	of	ADP
gs-4427	55	21	pathogenic	pathogenic	ADJ
gs-4427	55	22	mutations	mutation	NOUN
gs-4427	55	23	or	or	CCONJ
gs-4427	55	24	targeted	target	VERB
gs-4427	55	25	disruption	disruption	NOUN
gs-4427	55	26	of	of	ADP
gs-4427	55	27	disease	disease	NOUN
gs-4427	55	28	-	-	PUNCT
gs-4427	55	29	associated	associate	VERB
gs-4427	55	30	genes	gene	NOUN
gs-4427	55	31	.	.	PUNCT
gs-4427	56	1	the	the	DET
gs-4427	56	2	relative	relative	ADJ
gs-4427	56	3	simplicity	simplicity	NOUN
gs-4427	56	4	,	,	PUNCT
gs-4427	56	5	efficiency	efficiency	NOUN
gs-4427	56	6	,	,	PUNCT
gs-4427	56	7	and	and	CCONJ
gs-4427	56	8	versatility	versatility	NOUN
gs-4427	56	9	of	of	ADP
gs-4427	56	10	crispr	crispr	ADJ
gs-4427	56	11	technology	technology	NOUN
gs-4427	56	12	revolutionized	revolutionize	VERB
gs-4427	56	13	genetic	genetic	ADJ
gs-4427	56	14	engineering	engineering	NOUN
gs-4427	56	15	and	and	CCONJ
gs-4427	56	16	rapidly	rapidly	ADV
gs-4427	56	17	transitioned	transition	VERB
gs-4427	56	18	from	from	ADP
gs-4427	56	19	basic	basic	ADJ
gs-4427	56	20	research	research	NOUN
gs-4427	56	21	laboratories	laboratory	NOUN
gs-4427	56	22	to	to	ADP
gs-4427	56	23	clinical	clinical	ADJ
gs-4427	56	24	development	development	NOUN
gs-4427	56	25	.	.	PUNCT
gs-4427	57	1	the	the	DET
gs-4427	57	2	approval	approval	NOUN
gs-4427	57	3	of	of	ADP
gs-4427	57	4	the	the	DET
gs-4427	57	5	first	first	ADJ
gs-4427	57	6	crispr	crispr	NOUN
gs-4427	57	7	-	-	PUNCT
gs-4427	57	8	based	base	VERB
gs-4427	57	9	therapy	therapy	NOUN
gs-4427	57	10	represented	represent	VERB
gs-4427	57	11	a	a	DET
gs-4427	57	12	historic	historic	ADJ
gs-4427	57	13	milestone	milestone	NOUN
gs-4427	57	14	,	,	PUNCT
gs-4427	57	15	signaling	signal	VERB
gs-4427	57	16	the	the	DET
gs-4427	57	17	clinical	clinical	ADJ
gs-4427	57	18	feasibility	feasibility	NOUN
gs-4427	57	19	of	of	ADP
gs-4427	57	20	targeted	target	VERB
gs-4427	57	21	genome	genome	NOUN
gs-4427	57	22	editing	editing	NOUN
gs-4427	57	23	and	and	CCONJ
gs-4427	57	24	expanding	expand	VERB
gs-4427	57	25	the	the	DET
gs-4427	57	26	therapeutic	therapeutic	ADJ
gs-4427	57	27	scope	scope	NOUN
gs-4427	57	28	of	of	ADP
gs-4427	57	29	gene	gene	NOUN
gs-4427	57	30	therapy	therapy	NOUN
gs-4427	57	31	.	.	PUNCT
gs-4427	58	1	alongside	alongside	ADP
gs-4427	58	2	genome	genome	NOUN
gs-4427	58	3	editing	editing	NOUN
gs-4427	58	4	,	,	PUNCT
gs-4427	58	5	engineered	engineer	VERB
gs-4427	58	6	cell	cell	NOUN
gs-4427	58	7	therapies	therapy	NOUN
gs-4427	58	8	have	have	AUX
gs-4427	58	9	become	become	VERB
gs-4427	58	10	a	a	DET
gs-4427	58	11	dominant	dominant	ADJ
gs-4427	58	12	force	force	NOUN
gs-4427	58	13	within	within	ADP
gs-4427	58	14	the	the	DET
gs-4427	58	15	gene	gene	NOUN
gs-4427	58	16	therapy	therapy	NOUN
gs-4427	58	17	landscape	landscape	NOUN
gs-4427	58	18	.	.	PUNCT
gs-4427	59	1	chimeric	chimeric	ADJ
gs-4427	59	2	antigen	antigen	ADJ
gs-4427	59	3	receptor	receptor	NOUN
gs-4427	59	4	t	t	NOUN
gs-4427	59	5	-	-	PUNCT
gs-4427	59	6	cell	cell	NOUN
gs-4427	59	7	therapy	therapy	NOUN
gs-4427	59	8	exemplifies	exemplify	VERB
gs-4427	59	9	the	the	DET
gs-4427	59	10	successful	successful	ADJ
gs-4427	59	11	integration	integration	NOUN
gs-4427	59	12	of	of	ADP
gs-4427	59	13	genetic	genetic	ADJ
gs-4427	59	14	engineering	engineering	NOUN
gs-4427	59	15	with	with	ADP
gs-4427	59	16	immunotherapy	immunotherapy	NOUN
gs-4427	59	17	.	.	PUNCT
gs-4427	60	1	by	by	ADP
gs-4427	60	2	reprogramming	reprogramme	VERB
gs-4427	60	3	a	a	DET
gs-4427	60	4	patient	patient	NOUN
gs-4427	60	5	’s	’s	PART
gs-4427	60	6	own	own	ADJ
gs-4427	60	7	t	t	NOUN
gs-4427	60	8	lymphocytes	lymphocyte	VERB
gs-4427	60	9	to	to	PART
gs-4427	60	10	recognize	recognize	VERB
gs-4427	60	11	and	and	CCONJ
gs-4427	60	12	eliminate	eliminate	VERB
gs-4427	60	13	diseased	diseased	ADJ
gs-4427	60	14	cells	cell	NOUN
gs-4427	60	15	,	,	PUNCT
gs-4427	60	16	car	car	NOUN
gs-4427	60	17	-	-	PUNCT
gs-4427	60	18	t	t	NOUN
gs-4427	60	19	therapy	therapy	NOUN
gs-4427	60	20	has	have	AUX
gs-4427	60	21	achieved	achieve	VERB
gs-4427	60	22	unprecedented	unprecedented	ADJ
gs-4427	60	23	response	response	NOUN
gs-4427	60	24	rates	rate	NOUN
gs-4427	60	25	in	in	ADP
gs-4427	60	26	certain	certain	ADJ
gs-4427	60	27	hematological	hematological	ADJ
gs-4427	60	28	malignancies	malignancy	NOUN
gs-4427	60	29	.	.	PUNCT
gs-4427	61	1	the	the	DET
gs-4427	61	2	georgian	georgian	PROPN
gs-4427	61	3	scientists/	scientists/	NUM
gs-4427	61	4	.	.	PUNCT
gs-4427	62	1	7	7	NUM
gs-4427	62	2	n	n	DET
gs-4427	62	3	4	4	NUM
gs-4427	62	4	,	,	PUNCT
gs-4427	62	5	2025	2025	NUM
gs-4427	62	6	634	634	NUM
gs-4427	62	7	durability	durability	NOUN
gs-4427	62	8	of	of	ADP
gs-4427	62	9	responses	response	NOUN
gs-4427	62	10	observed	observe	VERB
gs-4427	62	11	in	in	ADP
gs-4427	62	12	treated	treat	VERB
gs-4427	62	13	patients	patient	NOUN
gs-4427	62	14	has	have	AUX
gs-4427	62	15	challenged	challenge	VERB
gs-4427	62	16	conventional	conventional	ADJ
gs-4427	62	17	notions	notion	NOUN
gs-4427	62	18	of	of	ADP
gs-4427	62	19	cancer	cancer	NOUN
gs-4427	62	20	therapy	therapy	NOUN
gs-4427	62	21	and	and	CCONJ
gs-4427	62	22	underscored	underscore	VERB
gs-4427	62	23	the	the	DET
gs-4427	62	24	potential	potential	NOUN
gs-4427	62	25	of	of	ADP
gs-4427	62	26	genetically	genetically	ADV
gs-4427	62	27	engineered	engineer	VERB
gs-4427	62	28	cells	cell	NOUN
gs-4427	62	29	as	as	ADP
gs-4427	62	30	living	live	VERB
gs-4427	62	31	drugs	drug	NOUN
gs-4427	62	32	.	.	PUNCT
gs-4427	63	1	ongoing	ongoing	ADJ
gs-4427	63	2	refinements	refinement	NOUN
gs-4427	63	3	in	in	ADP
gs-4427	63	4	receptor	receptor	NOUN
gs-4427	63	5	design	design	NOUN
gs-4427	63	6	,	,	PUNCT
gs-4427	63	7	cell	cell	NOUN
gs-4427	63	8	manufacturing	manufacturing	NOUN
gs-4427	63	9	,	,	PUNCT
gs-4427	63	10	and	and	CCONJ
gs-4427	63	11	toxicity	toxicity	NOUN
gs-4427	63	12	management	management	NOUN
gs-4427	63	13	continue	continue	VERB
gs-4427	63	14	to	to	PART
gs-4427	63	15	broaden	broaden	VERB
gs-4427	63	16	the	the	DET
gs-4427	63	17	applicability	applicability	NOUN
gs-4427	63	18	of	of	ADP
gs-4427	63	19	this	this	DET
gs-4427	63	20	approach	approach	NOUN
gs-4427	63	21	.	.	PUNCT
gs-4427	64	1	the	the	DET
gs-4427	64	2	expansion	expansion	NOUN
gs-4427	64	3	of	of	ADP
gs-4427	64	4	gene	gene	NOUN
gs-4427	64	5	therapy	therapy	NOUN
gs-4427	64	6	beyond	beyond	ADP
gs-4427	64	7	rare	rare	ADJ
gs-4427	64	8	monogenic	monogenic	ADJ
gs-4427	64	9	diseases	disease	NOUN
gs-4427	64	10	into	into	ADP
gs-4427	64	11	more	more	ADV
gs-4427	64	12	common	common	ADJ
gs-4427	64	13	and	and	CCONJ
gs-4427	64	14	complex	complex	ADJ
gs-4427	64	15	conditions	condition	NOUN
gs-4427	64	16	represents	represent	VERB
gs-4427	64	17	a	a	DET
gs-4427	64	18	critical	critical	ADJ
gs-4427	64	19	evolution	evolution	NOUN
gs-4427	64	20	of	of	ADP
gs-4427	64	21	the	the	DET
gs-4427	64	22	field	field	NOUN
gs-4427	64	23	.	.	PUNCT
gs-4427	65	1	advances	advance	NOUN
gs-4427	65	2	in	in	ADP
gs-4427	65	3	delivery	delivery	NOUN
gs-4427	65	4	systems	system	NOUN
gs-4427	65	5	,	,	PUNCT
gs-4427	65	6	gene	gene	NOUN
gs-4427	65	7	regulation	regulation	NOUN
gs-4427	65	8	,	,	PUNCT
gs-4427	65	9	and	and	CCONJ
gs-4427	65	10	editing	edit	VERB
gs-4427	65	11	precision	precision	NOUN
gs-4427	65	12	have	have	AUX
gs-4427	65	13	enabled	enable	VERB
gs-4427	65	14	exploration	exploration	NOUN
gs-4427	65	15	of	of	ADP
gs-4427	65	16	gene	gene	NOUN
gs-4427	65	17	-	-	PUNCT
gs-4427	65	18	based	base	VERB
gs-4427	65	19	interventions	intervention	NOUN
gs-4427	65	20	for	for	ADP
gs-4427	65	21	cardiovascular	cardiovascular	ADJ
gs-4427	65	22	disease	disease	NOUN
gs-4427	65	23	,	,	PUNCT
gs-4427	65	24	metabolic	metabolic	NOUN
gs-4427	65	25	disorders	disorder	NOUN
gs-4427	65	26	,	,	PUNCT
gs-4427	65	27	autoimmune	autoimmune	ADJ
gs-4427	65	28	diseases	disease	NOUN
gs-4427	65	29	,	,	PUNCT
gs-4427	65	30	and	and	CCONJ
gs-4427	65	31	neurodegenerative	neurodegenerative	ADJ
gs-4427	65	32	conditions	condition	NOUN
gs-4427	65	33	.	.	PUNCT
gs-4427	66	1	these	these	DET
gs-4427	66	2	efforts	effort	NOUN
gs-4427	66	3	reflect	reflect	VERB
gs-4427	66	4	growing	grow	VERB
gs-4427	66	5	confidence	confidence	NOUN
gs-4427	66	6	in	in	ADP
gs-4427	66	7	the	the	DET
gs-4427	66	8	safety	safety	NOUN
gs-4427	66	9	and	and	CCONJ
gs-4427	66	10	efficacy	efficacy	NOUN
gs-4427	66	11	of	of	ADP
gs-4427	66	12	gene	gene	NOUN
gs-4427	66	13	therapy	therapy	NOUN
gs-4427	66	14	platforms	platform	NOUN
gs-4427	66	15	,	,	PUNCT
gs-4427	66	16	as	as	ADV
gs-4427	66	17	well	well	ADV
gs-4427	66	18	as	as	ADP
gs-4427	66	19	recognition	recognition	NOUN
gs-4427	66	20	of	of	ADP
gs-4427	66	21	their	their	PRON
gs-4427	66	22	potential	potential	NOUN
gs-4427	66	23	to	to	PART
gs-4427	66	24	address	address	VERB
gs-4427	66	25	unmet	unmet	NOUN
gs-4427	66	26	medical	medical	ADJ
gs-4427	66	27	needs	need	NOUN
gs-4427	66	28	on	on	ADP
gs-4427	66	29	a	a	DET
gs-4427	66	30	broader	broad	ADJ
gs-4427	66	31	population	population	NOUN
gs-4427	66	32	scale	scale	NOUN
gs-4427	66	33	.	.	PUNCT
gs-4427	67	1	however	however	ADV
gs-4427	67	2	,	,	PUNCT
gs-4427	67	3	this	this	DET
gs-4427	67	4	expansion	expansion	NOUN
gs-4427	67	5	also	also	ADV
gs-4427	67	6	introduces	introduce	VERB
gs-4427	67	7	new	new	ADJ
gs-4427	67	8	ethical	ethical	ADJ
gs-4427	67	9	,	,	PUNCT
gs-4427	67	10	economic	economic	ADJ
gs-4427	67	11	,	,	PUNCT
gs-4427	67	12	and	and	CCONJ
gs-4427	67	13	clinical	clinical	ADJ
gs-4427	67	14	considerations	consideration	NOUN
gs-4427	67	15	,	,	PUNCT
gs-4427	67	16	particularly	particularly	ADV
gs-4427	67	17	when	when	SCONJ
gs-4427	67	18	applying	apply	VERB
gs-4427	67	19	irreversible	irreversible	ADJ
gs-4427	67	20	genetic	genetic	ADJ
gs-4427	67	21	interventions	intervention	NOUN
gs-4427	67	22	to	to	ADP
gs-4427	67	23	diseases	disease	NOUN
gs-4427	67	24	with	with	ADP
gs-4427	67	25	variable	variable	ADJ
gs-4427	67	26	severity	severity	NOUN
gs-4427	67	27	or	or	CCONJ
gs-4427	67	28	multifactorial	multifactorial	ADJ
gs-4427	67	29	etiology	etiology	NOUN
gs-4427	67	30	.	.	PUNCT
gs-4427	68	1	economic	economic	ADJ
gs-4427	68	2	and	and	CCONJ
gs-4427	68	3	access	access	NOUN
gs-4427	68	4	considerations	consideration	NOUN
gs-4427	68	5	have	have	AUX
gs-4427	68	6	emerged	emerge	VERB
gs-4427	68	7	as	as	ADP
gs-4427	68	8	central	central	ADJ
gs-4427	68	9	challenges	challenge	NOUN
gs-4427	68	10	in	in	ADP
gs-4427	68	11	the	the	DET
gs-4427	68	12	gene	gene	NOUN
gs-4427	68	13	therapy	therapy	NOUN
gs-4427	68	14	era	era	NOUN
gs-4427	68	15	.	.	PUNCT
gs-4427	69	1	the	the	DET
gs-4427	69	2	high	high	ADJ
gs-4427	69	3	cost	cost	NOUN
gs-4427	69	4	of	of	ADP
gs-4427	69	5	development	development	NOUN
gs-4427	69	6	,	,	PUNCT
gs-4427	69	7	manufacturing	manufacturing	NOUN
gs-4427	69	8	complexity	complexity	NOUN
gs-4427	69	9	,	,	PUNCT
gs-4427	69	10	and	and	CCONJ
gs-4427	69	11	limited	limited	ADJ
gs-4427	69	12	patient	patient	ADJ
gs-4427	69	13	populations	population	NOUN
gs-4427	69	14	for	for	ADP
gs-4427	69	15	many	many	ADJ
gs-4427	69	16	indications	indication	NOUN
gs-4427	69	17	have	have	AUX
gs-4427	69	18	resulted	result	VERB
gs-4427	69	19	in	in	ADP
gs-4427	69	20	unprecedented	unprecedented	ADJ
gs-4427	69	21	pricing	pricing	NOUN
gs-4427	69	22	for	for	ADP
gs-4427	69	23	approved	approve	VERB
gs-4427	69	24	therapies	therapy	NOUN
gs-4427	69	25	.	.	PUNCT
gs-4427	70	1	while	while	SCONJ
gs-4427	70	2	long	long	ADJ
gs-4427	70	3	-	-	PUNCT
gs-4427	70	4	term	term	NOUN
gs-4427	70	5	cost	cost	NOUN
gs-4427	70	6	-	-	PUNCT
gs-4427	70	7	effectiveness	effectiveness	NOUN
gs-4427	70	8	analyses	analysis	NOUN
gs-4427	70	9	often	often	ADV
gs-4427	70	10	support	support	VERB
gs-4427	70	11	the	the	DET
gs-4427	70	12	value	value	NOUN
gs-4427	70	13	of	of	ADP
gs-4427	70	14	potentially	potentially	ADV
gs-4427	70	15	curative	curative	ADJ
gs-4427	70	16	treatments	treatment	NOUN
gs-4427	70	17	,	,	PUNCT
gs-4427	70	18	the	the	DET
gs-4427	70	19	substantial	substantial	ADJ
gs-4427	70	20	upfront	upfront	ADJ
gs-4427	70	21	financial	financial	ADJ
gs-4427	70	22	burden	burden	NOUN
gs-4427	70	23	poses	pose	NOUN
gs-4427	70	24	challenges	challenge	NOUN
gs-4427	70	25	for	for	ADP
gs-4427	70	26	healthcare	healthcare	NOUN
gs-4427	70	27	systems	system	NOUN
gs-4427	70	28	,	,	PUNCT
gs-4427	70	29	insurers	insurer	NOUN
gs-4427	70	30	,	,	PUNCT
gs-4427	70	31	and	and	CCONJ
gs-4427	70	32	patients	patient	NOUN
gs-4427	70	33	.	.	PUNCT
gs-4427	71	1	innovative	innovative	ADJ
gs-4427	71	2	reimbursement	reimbursement	NOUN
gs-4427	71	3	models	model	NOUN
gs-4427	71	4	,	,	PUNCT
gs-4427	71	5	including	include	VERB
gs-4427	71	6	outcomes	outcome	NOUN
gs-4427	71	7	-	-	PUNCT
gs-4427	71	8	based	base	VERB
gs-4427	71	9	payments	payment	NOUN
gs-4427	71	10	and	and	CCONJ
gs-4427	71	11	annuity	annuity	NOUN
gs-4427	71	12	-	-	PUNCT
gs-4427	71	13	style	style	NOUN
gs-4427	71	14	financing	financing	NOUN
gs-4427	71	15	,	,	PUNCT
gs-4427	71	16	have	have	AUX
gs-4427	71	17	been	be	AUX
gs-4427	71	18	proposed	propose	VERB
gs-4427	71	19	to	to	PART
gs-4427	71	20	reconcile	reconcile	VERB
gs-4427	71	21	innovation	innovation	NOUN
gs-4427	71	22	with	with	ADP
gs-4427	71	23	affordability	affordability	NOUN
gs-4427	71	24	.	.	PUNCT
gs-4427	72	1	addressing	address	VERB
gs-4427	72	2	these	these	DET
gs-4427	72	3	economic	economic	ADJ
gs-4427	72	4	barriers	barrier	NOUN
gs-4427	72	5	is	be	AUX
gs-4427	72	6	essential	essential	ADJ
gs-4427	72	7	to	to	PART
gs-4427	72	8	ensure	ensure	VERB
gs-4427	72	9	equitable	equitable	ADJ
gs-4427	72	10	access	access	NOUN
gs-4427	72	11	and	and	CCONJ
gs-4427	72	12	prevent	prevent	VERB
gs-4427	72	13	widening	widen	VERB
gs-4427	72	14	disparities	disparity	NOUN
gs-4427	72	15	in	in	ADP
gs-4427	72	16	healthcare	healthcare	NOUN
gs-4427	72	17	delivery	delivery	NOUN
gs-4427	72	18	.	.	PUNCT
gs-4427	73	1	immunological	immunological	ADJ
gs-4427	73	2	factors	factor	NOUN
gs-4427	73	3	remain	remain	VERB
gs-4427	73	4	a	a	DET
gs-4427	73	5	critical	critical	ADJ
gs-4427	73	6	determinant	determinant	NOUN
gs-4427	73	7	of	of	ADP
gs-4427	73	8	gene	gene	NOUN
gs-4427	73	9	therapy	therapy	NOUN
gs-4427	73	10	success	success	NOUN
gs-4427	73	11	.	.	PUNCT
gs-4427	74	1	host	host	NOUN
gs-4427	74	2	immune	immune	ADJ
gs-4427	74	3	responses	response	NOUN
gs-4427	74	4	to	to	ADP
gs-4427	74	5	vectors	vector	NOUN
gs-4427	74	6	,	,	PUNCT
gs-4427	74	7	transgene	transgene	ADJ
gs-4427	74	8	products	product	NOUN
gs-4427	74	9	,	,	PUNCT
gs-4427	74	10	or	or	CCONJ
gs-4427	74	11	edited	edit	VERB
gs-4427	74	12	cells	cell	NOUN
gs-4427	74	13	can	can	AUX
gs-4427	74	14	limit	limit	VERB
gs-4427	74	15	efficacy	efficacy	NOUN
gs-4427	74	16	,	,	PUNCT
gs-4427	74	17	restrict	restrict	VERB
gs-4427	74	18	re	re	ADJ
gs-4427	74	19	-	-	VERB
gs-4427	74	20	dosing	dosing	ADJ
gs-4427	74	21	,	,	PUNCT
gs-4427	74	22	or	or	CCONJ
gs-4427	74	23	cause	cause	VERB
gs-4427	74	24	adverse	adverse	ADJ
gs-4427	74	25	effects	effect	NOUN
gs-4427	74	26	.	.	PUNCT
gs-4427	75	1	advances	advance	NOUN
gs-4427	75	2	in	in	ADP
gs-4427	75	3	vector	vector	NOUN
gs-4427	75	4	engineering	engineering	NOUN
gs-4427	75	5	,	,	PUNCT
gs-4427	75	6	immune	immune	ADJ
gs-4427	75	7	modulation	modulation	NOUN
gs-4427	75	8	strategies	strategy	NOUN
gs-4427	75	9	,	,	PUNCT
gs-4427	75	10	and	and	CCONJ
gs-4427	75	11	patient	patient	ADJ
gs-4427	75	12	selection	selection	NOUN
gs-4427	75	13	criteria	criterion	NOUN
gs-4427	75	14	have	have	AUX
gs-4427	75	15	mitigated	mitigate	VERB
gs-4427	75	16	some	some	PRON
gs-4427	75	17	of	of	ADP
gs-4427	75	18	these	these	DET
gs-4427	75	19	challenges	challenge	NOUN
gs-4427	75	20	,	,	PUNCT
gs-4427	75	21	but	but	CCONJ
gs-4427	75	22	immunogenicity	immunogenicity	NOUN
gs-4427	75	23	continues	continue	VERB
gs-4427	75	24	to	to	PART
gs-4427	75	25	influence	influence	VERB
gs-4427	75	26	therapeutic	therapeutic	ADJ
gs-4427	75	27	outcomes	outcome	NOUN
gs-4427	75	28	.	.	PUNCT
gs-4427	76	1	a	a	DET
gs-4427	76	2	deeper	deep	ADJ
gs-4427	76	3	understanding	understanding	NOUN
gs-4427	76	4	of	of	ADP
gs-4427	76	5	immune	immune	ADJ
gs-4427	76	6	tolerance	tolerance	NOUN
gs-4427	76	7	mechanisms	mechanism	NOUN
gs-4427	76	8	and	and	CCONJ
gs-4427	76	9	the	the	DET
gs-4427	76	10	development	development	NOUN
gs-4427	76	11	of	of	ADP
gs-4427	76	12	less	less	ADJ
gs-4427	76	13	immunogenic	immunogenic	ADJ
gs-4427	76	14	delivery	delivery	NOUN
gs-4427	76	15	systems	system	NOUN
gs-4427	76	16	will	will	AUX
gs-4427	76	17	be	be	AUX
gs-4427	76	18	essential	essential	ADJ
gs-4427	76	19	for	for	ADP
gs-4427	76	20	expanding	expand	VERB
gs-4427	76	21	the	the	DET
gs-4427	76	22	range	range	NOUN
gs-4427	76	23	of	of	ADP
gs-4427	76	24	treatable	treatable	ADJ
gs-4427	76	25	patients	patient	NOUN
gs-4427	76	26	and	and	CCONJ
gs-4427	76	27	indications	indication	NOUN
gs-4427	76	28	.	.	PUNCT
gs-4427	77	1	ethical	ethical	ADJ
gs-4427	77	2	considerations	consideration	NOUN
gs-4427	77	3	also	also	ADV
gs-4427	77	4	play	play	VERB
gs-4427	77	5	a	a	DET
gs-4427	77	6	prominent	prominent	ADJ
gs-4427	77	7	role	role	NOUN
gs-4427	77	8	in	in	ADP
gs-4427	77	9	shaping	shape	VERB
gs-4427	77	10	the	the	DET
gs-4427	77	11	future	future	NOUN
gs-4427	77	12	of	of	ADP
gs-4427	77	13	gene	gene	NOUN
gs-4427	77	14	therapy	therapy	NOUN
gs-4427	77	15	.	.	PUNCT
gs-4427	78	1	issues	issue	NOUN
gs-4427	78	2	related	relate	VERB
gs-4427	78	3	to	to	ADP
gs-4427	78	4	informed	informed	ADJ
gs-4427	78	5	consent	consent	NOUN
gs-4427	78	6	,	,	PUNCT
gs-4427	78	7	long	long	ADJ
gs-4427	78	8	-	-	PUNCT
gs-4427	78	9	term	term	NOUN
gs-4427	78	10	risk	risk	NOUN
gs-4427	78	11	,	,	PUNCT
gs-4427	78	12	intergenerational	intergenerational	ADJ
gs-4427	78	13	effects	effect	NOUN
gs-4427	78	14	,	,	PUNCT
gs-4427	78	15	and	and	CCONJ
gs-4427	78	16	equitable	equitable	ADJ
gs-4427	78	17	access	access	NOUN
gs-4427	78	18	require	require	VERB
gs-4427	78	19	careful	careful	ADJ
gs-4427	78	20	deliberation	deliberation	NOUN
gs-4427	78	21	by	by	ADP
gs-4427	78	22	clinicians	clinician	NOUN
gs-4427	78	23	,	,	PUNCT
gs-4427	78	24	researchers	researcher	NOUN
gs-4427	78	25	,	,	PUNCT
gs-4427	78	26	regulators	regulator	NOUN
gs-4427	78	27	,	,	PUNCT
gs-4427	78	28	and	and	CCONJ
gs-4427	78	29	society	society	NOUN
gs-4427	78	30	at	at	ADP
gs-4427	78	31	large	large	ADJ
gs-4427	78	32	.	.	PUNCT
gs-4427	79	1	while	while	SCONJ
gs-4427	79	2	current	current	ADJ
gs-4427	79	3	clinical	clinical	ADJ
gs-4427	79	4	applications	application	NOUN
gs-4427	79	5	focus	focus	VERB
gs-4427	79	6	on	on	ADP
gs-4427	79	7	somatic	somatic	ADJ
gs-4427	79	8	gene	gene	NOUN
gs-4427	79	9	therapy	therapy	NOUN
gs-4427	79	10	,	,	PUNCT
gs-4427	79	11	ongoing	ongoing	ADJ
gs-4427	79	12	debates	debate	NOUN
gs-4427	79	13	surrounding	surround	VERB
gs-4427	79	14	germline	germline	NOUN
gs-4427	79	15	editing	edit	VERB
gs-4427	79	16	highlight	highlight	ADP
gs-4427	79	17	the	the	DET
gs-4427	79	18	need	need	NOUN
gs-4427	79	19	for	for	ADP
gs-4427	79	20	clear	clear	ADJ
gs-4427	79	21	ethical	ethical	ADJ
gs-4427	79	22	boundaries	boundary	NOUN
gs-4427	79	23	and	and	CCONJ
gs-4427	79	24	international	international	ADJ
gs-4427	79	25	consensus	consensus	NOUN
gs-4427	79	26	.	.	PUNCT
gs-4427	80	1	transparent	transparent	ADJ
gs-4427	80	2	communication	communication	NOUN
gs-4427	80	3	,	,	PUNCT
gs-4427	80	4	patient	patient	ADJ
gs-4427	80	5	engagement	engagement	NOUN
gs-4427	80	6	,	,	PUNCT
gs-4427	80	7	and	and	CCONJ
gs-4427	80	8	responsible	responsible	ADJ
gs-4427	80	9	governance	governance	NOUN
gs-4427	80	10	are	be	AUX
gs-4427	80	11	fundamental	fundamental	ADJ
gs-4427	80	12	to	to	ADP
gs-4427	80	13	maintaining	maintain	VERB
gs-4427	80	14	public	public	ADJ
gs-4427	80	15	trust	trust	NOUN
gs-4427	80	16	in	in	ADP
gs-4427	80	17	genetic	genetic	ADJ
gs-4427	80	18	medicine	medicine	NOUN
gs-4427	80	19	.	.	PUNCT
gs-4427	81	1	from	from	ADP
gs-4427	81	2	a	a	DET
gs-4427	81	3	clinical	clinical	ADJ
gs-4427	81	4	perspective	perspective	NOUN
gs-4427	81	5	,	,	PUNCT
gs-4427	81	6	the	the	DET
gs-4427	81	7	integration	integration	NOUN
gs-4427	81	8	of	of	ADP
gs-4427	81	9	gene	gene	NOUN
gs-4427	81	10	therapy	therapy	NOUN
gs-4427	81	11	into	into	ADP
gs-4427	81	12	routine	routine	ADJ
gs-4427	81	13	medical	medical	ADJ
gs-4427	81	14	practice	practice	NOUN
gs-4427	81	15	necessitates	necessitate	VERB
gs-4427	81	16	multidisciplinary	multidisciplinary	ADJ
gs-4427	81	17	collaboration	collaboration	NOUN
gs-4427	81	18	and	and	CCONJ
gs-4427	81	19	specialized	specialized	ADJ
gs-4427	81	20	expertise	expertise	NOUN
gs-4427	81	21	.	.	PUNCT
gs-4427	82	1	the	the	DET
gs-4427	82	2	administration	administration	NOUN
gs-4427	82	3	and	and	CCONJ
gs-4427	82	4	monitoring	monitoring	NOUN
gs-4427	82	5	of	of	ADP
gs-4427	82	6	gene	gene	NOUN
gs-4427	82	7	and	and	CCONJ
gs-4427	82	8	cell	cell	NOUN
gs-4427	82	9	therapies	therapy	NOUN
gs-4427	82	10	require	require	VERB
gs-4427	82	11	coordinated	coordinate	VERB
gs-4427	82	12	efforts	effort	NOUN
gs-4427	82	13	among	among	ADP
gs-4427	82	14	physicians	physician	NOUN
gs-4427	82	15	,	,	PUNCT
gs-4427	82	16	pharmacists	pharmacist	NOUN
gs-4427	82	17	,	,	PUNCT
gs-4427	82	18	geneticists	geneticist	NOUN
gs-4427	82	19	,	,	PUNCT
gs-4427	82	20	immunologists	immunologist	NOUN
gs-4427	82	21	,	,	PUNCT
gs-4427	82	22	and	and	CCONJ
gs-4427	82	23	allied	ally	VERB
gs-4427	82	24	healthcare	healthcare	NOUN
gs-4427	82	25	professionals	professional	NOUN
gs-4427	82	26	.	.	PUNCT
gs-4427	83	1	education	education	NOUN
gs-4427	83	2	and	and	CCONJ
gs-4427	83	3	georgian	georgian	NOUN
gs-4427	83	4	scientists/	scientists/	NUM
gs-4427	83	5	.	.	PUNCT
gs-4427	84	1	7	7	NUM
gs-4427	84	2	n	n	DET
gs-4427	84	3	4	4	NUM
gs-4427	84	4	,	,	PUNCT
gs-4427	84	5	2025	2025	NUM
gs-4427	84	6	635	635	NUM
gs-4427	84	7	training	training	NOUN
gs-4427	84	8	programs	program	NOUN
gs-4427	84	9	must	must	AUX
gs-4427	84	10	evolve	evolve	VERB
gs-4427	84	11	to	to	PART
gs-4427	84	12	equip	equip	VERB
gs-4427	84	13	healthcare	healthcare	NOUN
gs-4427	84	14	providers	provider	NOUN
gs-4427	84	15	with	with	ADP
gs-4427	84	16	the	the	DET
gs-4427	84	17	knowledge	knowledge	NOUN
gs-4427	84	18	and	and	CCONJ
gs-4427	84	19	skills	skill	NOUN
gs-4427	84	20	required	require	VERB
gs-4427	84	21	to	to	PART
gs-4427	84	22	manage	manage	VERB
gs-4427	84	23	these	these	DET
gs-4427	84	24	complex	complex	ADJ
gs-4427	84	25	therapies	therapy	NOUN
gs-4427	84	26	safely	safely	ADV
gs-4427	84	27	and	and	CCONJ
gs-4427	84	28	effectively	effectively	ADV
gs-4427	84	29	.	.	PUNCT
gs-4427	85	1	in	in	ADP
gs-4427	85	2	parallel	parallel	NOUN
gs-4427	85	3	,	,	PUNCT
gs-4427	85	4	healthcare	healthcare	NOUN
gs-4427	85	5	infrastructure	infrastructure	NOUN
gs-4427	85	6	must	must	AUX
gs-4427	85	7	adapt	adapt	VERB
gs-4427	85	8	to	to	PART
gs-4427	85	9	support	support	VERB
gs-4427	85	10	specialized	specialized	ADJ
gs-4427	85	11	manufacturing	manufacturing	NOUN
gs-4427	85	12	,	,	PUNCT
gs-4427	85	13	storage	storage	NOUN
gs-4427	85	14	,	,	PUNCT
gs-4427	85	15	administration	administration	NOUN
gs-4427	85	16	,	,	PUNCT
gs-4427	85	17	and	and	CCONJ
gs-4427	85	18	long	long	ADJ
gs-4427	85	19	-	-	PUNCT
gs-4427	85	20	term	term	NOUN
gs-4427	85	21	follow	follow	NOUN
gs-4427	85	22	-	-	PUNCT
gs-4427	85	23	up	up	ADP
gs-4427	85	24	requirements	requirement	NOUN
gs-4427	85	25	.	.	PUNCT
gs-4427	86	1	in	in	ADP
gs-4427	86	2	the	the	DET
gs-4427	86	3	broader	broad	ADJ
gs-4427	86	4	context	context	NOUN
gs-4427	86	5	of	of	ADP
gs-4427	86	6	biomedical	biomedical	ADJ
gs-4427	86	7	innovation	innovation	NOUN
gs-4427	86	8	,	,	PUNCT
gs-4427	86	9	gene	gene	NOUN
gs-4427	86	10	therapy	therapy	NOUN
gs-4427	86	11	exemplifies	exemplify	VERB
gs-4427	86	12	the	the	DET
gs-4427	86	13	convergence	convergence	NOUN
gs-4427	86	14	of	of	ADP
gs-4427	86	15	multiple	multiple	ADJ
gs-4427	86	16	scientific	scientific	ADJ
gs-4427	86	17	disciplines	discipline	NOUN
gs-4427	86	18	,	,	PUNCT
gs-4427	86	19	including	include	VERB
gs-4427	86	20	molecular	molecular	ADJ
gs-4427	86	21	biology	biology	NOUN
gs-4427	86	22	,	,	PUNCT
gs-4427	86	23	bioengineering	bioengineering	NOUN
gs-4427	86	24	,	,	PUNCT
gs-4427	86	25	computational	computational	ADJ
gs-4427	86	26	science	science	NOUN
gs-4427	86	27	,	,	PUNCT
gs-4427	86	28	and	and	CCONJ
gs-4427	86	29	clinical	clinical	ADJ
gs-4427	86	30	medicine	medicine	NOUN
gs-4427	86	31	.	.	PUNCT
gs-4427	87	1	advances	advance	NOUN
gs-4427	87	2	in	in	ADP
gs-4427	87	3	bioinformatics	bioinformatics	NOUN
gs-4427	87	4	and	and	CCONJ
gs-4427	87	5	artificial	artificial	ADJ
gs-4427	87	6	intelligence	intelligence	NOUN
gs-4427	87	7	are	be	AUX
gs-4427	87	8	increasingly	increasingly	ADV
gs-4427	87	9	applied	apply	VERB
gs-4427	87	10	to	to	ADP
gs-4427	87	11	vector	vector	NOUN
gs-4427	87	12	design	design	NOUN
gs-4427	87	13	,	,	PUNCT
gs-4427	87	14	target	target	NOUN
gs-4427	87	15	identification	identification	NOUN
gs-4427	87	16	,	,	PUNCT
gs-4427	87	17	and	and	CCONJ
gs-4427	87	18	prediction	prediction	NOUN
gs-4427	87	19	of	of	ADP
gs-4427	87	20	off	off	ADP
gs-4427	87	21	-	-	PUNCT
gs-4427	87	22	target	target	NOUN
gs-4427	87	23	effects	effect	NOUN
gs-4427	87	24	,	,	PUNCT
gs-4427	87	25	further	far	ADV
gs-4427	87	26	accelerating	accelerate	VERB
gs-4427	87	27	development	development	NOUN
gs-4427	87	28	timelines	timeline	NOUN
gs-4427	87	29	.	.	PUNCT
gs-4427	88	1	these	these	DET
gs-4427	88	2	integrative	integrative	ADJ
gs-4427	88	3	approaches	approach	NOUN
gs-4427	88	4	are	be	AUX
gs-4427	88	5	expected	expect	VERB
gs-4427	88	6	to	to	PART
gs-4427	88	7	enhance	enhance	VERB
gs-4427	88	8	precision	precision	NOUN
gs-4427	88	9	,	,	PUNCT
gs-4427	88	10	reduce	reduce	VERB
gs-4427	88	11	risk	risk	NOUN
gs-4427	88	12	,	,	PUNCT
gs-4427	88	13	and	and	CCONJ
gs-4427	88	14	enable	enable	VERB
gs-4427	88	15	personalized	personalized	ADJ
gs-4427	88	16	therapeutic	therapeutic	ADJ
gs-4427	88	17	strategies	strategy	NOUN
gs-4427	88	18	tailored	tailor	VERB
gs-4427	88	19	to	to	ADP
gs-4427	88	20	individual	individual	ADJ
gs-4427	88	21	genetic	genetic	ADJ
gs-4427	88	22	profiles	profile	NOUN
gs-4427	88	23	.	.	PUNCT
gs-4427	89	1	the	the	DET
gs-4427	89	2	renaissance	renaissance	NOUN
gs-4427	89	3	:	:	PUNCT
gs-4427	89	4	technological	technological	ADJ
gs-4427	89	5	breakthroughs	breakthrough	NOUN
gs-4427	89	6	enabling	enable	VERB
gs-4427	89	7	clinical	clinical	ADJ
gs-4427	89	8	success	success	NOUN
gs-4427	89	9	the	the	DET
gs-4427	89	10	gene	gene	NOUN
gs-4427	89	11	therapy	therapy	NOUN
gs-4427	89	12	field	field	NOUN
gs-4427	89	13	experienced	experience	VERB
gs-4427	89	14	a	a	DET
gs-4427	89	15	renaissance	renaissance	NOUN
gs-4427	89	16	beginning	begin	VERB
gs-4427	89	17	in	in	ADP
gs-4427	89	18	the	the	DET
gs-4427	89	19	late	late	ADJ
gs-4427	89	20	2000s	2000	NOUN
gs-4427	89	21	and	and	CCONJ
gs-4427	89	22	accelerating	accelerate	VERB
gs-4427	89	23	through	through	ADP
gs-4427	89	24	the	the	DET
gs-4427	89	25	2010s	2010s	NUM
gs-4427	89	26	,	,	PUNCT
gs-4427	89	27	driven	drive	VERB
gs-4427	89	28	by	by	ADP
gs-4427	89	29	convergent	convergent	ADJ
gs-4427	89	30	technological	technological	ADJ
gs-4427	89	31	innovations	innovation	NOUN
gs-4427	89	32	that	that	PRON
gs-4427	89	33	addressed	address	VERB
gs-4427	89	34	earlier	early	ADJ
gs-4427	89	35	limitations	limitation	NOUN
gs-4427	89	36	.	.	PUNCT
gs-4427	90	1	the	the	DET
gs-4427	90	2	development	development	NOUN
gs-4427	90	3	and	and	CCONJ
gs-4427	90	4	refinement	refinement	NOUN
gs-4427	90	5	of	of	ADP
gs-4427	90	6	adeno	adeno	NOUN
gs-4427	90	7	-	-	PUNCT
gs-4427	90	8	associated	associate	VERB
gs-4427	90	9	virus	virus	NOUN
gs-4427	90	10	vectors	vector	NOUN
gs-4427	90	11	represented	represent	VERB
gs-4427	90	12	a	a	DET
gs-4427	90	13	crucial	crucial	ADJ
gs-4427	90	14	advance	advance	NOUN
gs-4427	90	15	,	,	PUNCT
gs-4427	90	16	offering	offer	VERB
gs-4427	90	17	significant	significant	ADJ
gs-4427	90	18	advantages	advantage	NOUN
gs-4427	90	19	over	over	ADP
gs-4427	90	20	earlier	early	ADJ
gs-4427	90	21	retroviral	retroviral	ADJ
gs-4427	90	22	and	and	CCONJ
gs-4427	90	23	adenoviral	adenoviral	ADJ
gs-4427	90	24	platforms	platform	NOUN
gs-4427	90	25	.	.	PUNCT
gs-4427	91	1	aav	aav	NOUN
gs-4427	91	2	vectors	vector	NOUN
gs-4427	91	3	demonstrated	demonstrate	VERB
gs-4427	91	4	favorable	favorable	ADJ
gs-4427	91	5	safety	safety	NOUN
gs-4427	91	6	profiles	profile	NOUN
gs-4427	91	7	with	with	ADP
gs-4427	91	8	minimal	minimal	ADJ
gs-4427	91	9	immunogenicity	immunogenicity	NOUN
gs-4427	91	10	,	,	PUNCT
gs-4427	91	11	broad	broad	ADJ
gs-4427	91	12	tissue	tissue	NOUN
gs-4427	91	13	tropism	tropism	NOUN
gs-4427	91	14	through	through	ADP
gs-4427	91	15	diverse	diverse	ADJ
gs-4427	91	16	natural	natural	ADJ
gs-4427	91	17	serotypes	serotype	NOUN
gs-4427	91	18	and	and	CCONJ
gs-4427	91	19	engineered	engineer	VERB
gs-4427	91	20	variants	variant	NOUN
gs-4427	91	21	,	,	PUNCT
gs-4427	91	22	and	and	CCONJ
gs-4427	91	23	the	the	DET
gs-4427	91	24	capacity	capacity	NOUN
gs-4427	91	25	to	to	PART
gs-4427	91	26	transduce	transduce	VERB
gs-4427	91	27	both	both	CCONJ
gs-4427	91	28	dividing	dividing	NOUN
gs-4427	91	29	and	and	CCONJ
gs-4427	91	30	post	post	ADJ
gs-4427	91	31	-	-	ADJ
gs-4427	91	32	mitotic	mitotic	ADJ
gs-4427	91	33	cells	cell	NOUN
gs-4427	91	34	.	.	PUNCT
gs-4427	92	1	critically	critically	ADV
gs-4427	92	2	,	,	PUNCT
gs-4427	92	3	aav	aav	PROPN
gs-4427	92	4	vectors	vector	NOUN
gs-4427	92	5	predominantly	predominantly	ADV
gs-4427	92	6	remained	remain	VERB
gs-4427	92	7	episomal	episomal	ADJ
gs-4427	92	8	rather	rather	ADV
gs-4427	92	9	than	than	ADP
gs-4427	92	10	integrating	integrate	VERB
gs-4427	92	11	into	into	ADP
gs-4427	92	12	the	the	DET
gs-4427	92	13	host	host	NOUN
gs-4427	92	14	genome	genome	NOUN
gs-4427	92	15	,	,	PUNCT
gs-4427	92	16	substantially	substantially	ADV
gs-4427	92	17	reducing	reduce	VERB
gs-4427	92	18	insertional	insertional	ADJ
gs-4427	92	19	mutagenesis	mutagenesis	NOUN
gs-4427	92	20	risks	risk	NOUN
gs-4427	92	21	.	.	PUNCT
gs-4427	93	1	the	the	DET
gs-4427	93	2	small	small	ADJ
gs-4427	93	3	size	size	NOUN
gs-4427	93	4	of	of	ADP
gs-4427	93	5	aav	aav	NOUN
gs-4427	93	6	virions	virion	NOUN
gs-4427	93	7	facilitated	facilitate	VERB
gs-4427	93	8	manufacturing	manufacturing	NOUN
gs-4427	93	9	scale	scale	NOUN
gs-4427	93	10	-	-	PUNCT
gs-4427	93	11	up	up	NOUN
gs-4427	93	12	,	,	PUNCT
gs-4427	93	13	while	while	SCONJ
gs-4427	93	14	the	the	DET
gs-4427	93	15	existence	existence	NOUN
gs-4427	93	16	of	of	ADP
gs-4427	93	17	multiple	multiple	ADJ
gs-4427	93	18	serotypes	serotype	NOUN
gs-4427	93	19	with	with	ADP
gs-4427	93	20	distinct	distinct	ADJ
gs-4427	93	21	tissue	tissue	NOUN
gs-4427	93	22	tropisms	tropism	NOUN
gs-4427	93	23	enabled	enable	VERB
gs-4427	93	24	targeted	target	VERB
gs-4427	93	25	delivery	delivery	NOUN
gs-4427	93	26	to	to	ADP
gs-4427	93	27	specific	specific	ADJ
gs-4427	93	28	organs	organ	NOUN
gs-4427	93	29	including	include	VERB
gs-4427	93	30	liver	liver	NOUN
gs-4427	93	31	,	,	PUNCT
gs-4427	93	32	muscle	muscle	NOUN
gs-4427	93	33	,	,	PUNCT
gs-4427	93	34	retina	retina	NOUN
gs-4427	93	35	,	,	PUNCT
gs-4427	93	36	and	and	CCONJ
gs-4427	93	37	central	central	ADJ
gs-4427	93	38	nervous	nervous	ADJ
gs-4427	93	39	system	system	NOUN
gs-4427	93	40	.	.	PUNCT
gs-4427	94	1	the	the	DET
gs-4427	94	2	engineering	engineering	NOUN
gs-4427	94	3	of	of	ADP
gs-4427	94	4	self	self	NOUN
gs-4427	94	5	-	-	PUNCT
gs-4427	94	6	inactivating	inactivate	VERB
gs-4427	94	7	lentiviral	lentiviral	ADJ
gs-4427	94	8	vectors	vector	NOUN
gs-4427	94	9	derived	derive	VERB
gs-4427	94	10	from	from	ADP
gs-4427	94	11	human	human	ADJ
gs-4427	94	12	immunodeficiency	immunodeficiency	NOUN
gs-4427	94	13	virus	virus	NOUN
gs-4427	94	14	type	type	NOUN
gs-4427	94	15	1	1	NUM
gs-4427	94	16	provided	provide	VERB
gs-4427	94	17	another	another	DET
gs-4427	94	18	critical	critical	ADJ
gs-4427	94	19	technological	technological	ADJ
gs-4427	94	20	advancement	advancement	NOUN
gs-4427	94	21	for	for	ADP
gs-4427	94	22	ex	ex	PRON
gs-4427	94	23	vivo	vivo	NOUN
gs-4427	94	24	gene	gene	NOUN
gs-4427	94	25	therapy	therapy	NOUN
gs-4427	94	26	applications	application	NOUN
gs-4427	94	27	.	.	PUNCT
gs-4427	95	1	unlike	unlike	ADP
gs-4427	95	2	earlier	early	ADJ
gs-4427	95	3	gamma	gamma	NOUN
gs-4427	95	4	-	-	PUNCT
gs-4427	95	5	retroviral	retroviral	ADJ
gs-4427	95	6	vectors	vector	NOUN
gs-4427	95	7	,	,	PUNCT
gs-4427	95	8	lentiviral	lentiviral	ADJ
gs-4427	95	9	vectors	vector	NOUN
gs-4427	95	10	could	could	AUX
gs-4427	95	11	transduce	transduce	VERB
gs-4427	95	12	non	non	ADJ
gs-4427	95	13	-	-	ADJ
gs-4427	95	14	dividing	dividing	ADJ
gs-4427	95	15	cells	cell	NOUN
gs-4427	95	16	and	and	CCONJ
gs-4427	95	17	demonstrated	demonstrate	VERB
gs-4427	95	18	reduced	reduced	ADJ
gs-4427	95	19	genotoxicity	genotoxicity	NOUN
gs-4427	95	20	due	due	ADP
gs-4427	95	21	to	to	ADP
gs-4427	95	22	different	different	ADJ
gs-4427	95	23	integration	integration	NOUN
gs-4427	95	24	site	site	NOUN
gs-4427	95	25	preferences	preference	NOUN
gs-4427	95	26	,	,	PUNCT
gs-4427	95	27	favoring	favor	VERB
gs-4427	95	28	gene	gene	NOUN
gs-4427	95	29	bodies	body	NOUN
gs-4427	95	30	over	over	ADP
gs-4427	95	31	promoter	promoter	NOUN
gs-4427	95	32	regions	region	NOUN
gs-4427	95	33	.	.	PUNCT
gs-4427	96	1	the	the	DET
gs-4427	96	2	incorporation	incorporation	NOUN
gs-4427	96	3	of	of	ADP
gs-4427	96	4	safety	safety	NOUN
gs-4427	96	5	modifications	modification	NOUN
gs-4427	96	6	including	include	VERB
gs-4427	96	7	deletion	deletion	NOUN
gs-4427	96	8	of	of	ADP
gs-4427	96	9	viral	viral	ADJ
gs-4427	96	10	regulatory	regulatory	ADJ
gs-4427	96	11	elements	element	NOUN
gs-4427	96	12	,	,	PUNCT
gs-4427	96	13	separation	separation	NOUN
gs-4427	96	14	of	of	ADP
gs-4427	96	15	packaging	packaging	NOUN
gs-4427	96	16	components	component	NOUN
gs-4427	96	17	across	across	ADP
gs-4427	96	18	multiple	multiple	ADJ
gs-4427	96	19	plasmids	plasmid	NOUN
gs-4427	96	20	,	,	PUNCT
gs-4427	96	21	and	and	CCONJ
gs-4427	96	22	replacement	replacement	NOUN
gs-4427	96	23	of	of	ADP
gs-4427	96	24	the	the	DET
gs-4427	96	25	viral	viral	ADJ
gs-4427	96	26	envelope	envelope	NOUN
gs-4427	96	27	with	with	ADP
gs-4427	96	28	vesicular	vesicular	ADJ
gs-4427	96	29	stomatitis	stomatitis	NOUN
gs-4427	96	30	virus	virus	NOUN
gs-4427	96	31	g	g	NOUN
gs-4427	96	32	protein	protein	NOUN
gs-4427	96	33	enhanced	enhance	VERB
gs-4427	96	34	biosafety	biosafety	NOUN
gs-4427	96	35	profiles	profile	NOUN
gs-4427	96	36	.	.	PUNCT
gs-4427	97	1	these	these	DET
gs-4427	97	2	improvements	improvement	NOUN
gs-4427	97	3	made	make	VERB
gs-4427	97	4	lentiviral	lentiviral	ADJ
gs-4427	97	5	vectors	vector	NOUN
gs-4427	97	6	the	the	DET
gs-4427	97	7	preferred	preferred	ADJ
gs-4427	97	8	platform	platform	NOUN
gs-4427	97	9	for	for	ADP
gs-4427	97	10	ex	ex	PRON
gs-4427	97	11	vivo	vivo	ADJ
gs-4427	97	12	transduction	transduction	NOUN
gs-4427	97	13	of	of	ADP
gs-4427	97	14	hematopoietic	hematopoietic	ADJ
gs-4427	97	15	stem	stem	NOUN
gs-4427	97	16	cells	cell	NOUN
gs-4427	97	17	and	and	CCONJ
gs-4427	97	18	t	t	NOUN
gs-4427	97	19	lymphocytes	lymphocyte	NOUN
gs-4427	97	20	,	,	PUNCT
gs-4427	97	21	enabling	enable	VERB
gs-4427	97	22	successful	successful	ADJ
gs-4427	97	23	development	development	NOUN
gs-4427	97	24	of	of	ADP
gs-4427	97	25	car	car	NOUN
gs-4427	97	26	-	-	PUNCT
gs-4427	97	27	t	t	NOUN
gs-4427	97	28	cell	cell	NOUN
gs-4427	97	29	therapies	therapy	NOUN
gs-4427	97	30	and	and	CCONJ
gs-4427	97	31	genecorrected	genecorrecte	VERB
gs-4427	97	32	stem	stem	NOUN
gs-4427	97	33	cell	cell	NOUN
gs-4427	97	34	treatments	treatment	NOUN
gs-4427	97	35	for	for	ADP
gs-4427	97	36	blood	blood	NOUN
gs-4427	97	37	disorders	disorder	NOUN
gs-4427	97	38	and	and	CCONJ
gs-4427	97	39	lysosomal	lysosomal	ADJ
gs-4427	97	40	storage	storage	NOUN
gs-4427	97	41	diseases	disease	NOUN
gs-4427	97	42	.	.	PUNCT
gs-4427	98	1	the	the	DET
gs-4427	98	2	discovery	discovery	NOUN
gs-4427	98	3	and	and	CCONJ
gs-4427	98	4	adaptation	adaptation	NOUN
gs-4427	98	5	of	of	ADP
gs-4427	98	6	crispr	crispr	ADJ
gs-4427	98	7	-	-	PUNCT
gs-4427	98	8	cas9	cas9	NOUN
gs-4427	98	9	gene	gene	NOUN
gs-4427	98	10	editing	edit	VERB
gs-4427	98	11	technology	technology	NOUN
gs-4427	98	12	represented	represent	VERB
gs-4427	98	13	perhaps	perhaps	ADV
gs-4427	98	14	the	the	DET
gs-4427	98	15	most	most	ADV
gs-4427	98	16	transformative	transformative	ADJ
gs-4427	98	17	innovation	innovation	NOUN
gs-4427	98	18	in	in	ADP
gs-4427	98	19	modern	modern	ADJ
gs-4427	98	20	molecular	molecular	ADJ
gs-4427	98	21	biology	biology	NOUN
gs-4427	98	22	,	,	PUNCT
gs-4427	98	23	fundamentally	fundamentally	ADV
gs-4427	98	24	expanding	expand	VERB
gs-4427	98	25	gene	gene	NOUN
gs-4427	98	26	therapy	therapy	NOUN
gs-4427	98	27	capabilities	capability	NOUN
gs-4427	98	28	beyond	beyond	ADP
gs-4427	98	29	simple	simple	ADJ
gs-4427	98	30	gene	gene	NOUN
gs-4427	98	31	addition	addition	NOUN
gs-4427	98	32	.	.	PUNCT
gs-4427	99	1	adapted	adapt	VERB
gs-4427	99	2	from	from	ADP
gs-4427	99	3	a	a	DET
gs-4427	99	4	bacterial	bacterial	ADJ
gs-4427	99	5	georgian	georgian	NOUN
gs-4427	99	6	scientists/	scientists/	NUM
gs-4427	99	7	.	.	PUNCT
gs-4427	100	1	7	7	NUM
gs-4427	100	2	n	n	DET
gs-4427	100	3	4	4	NUM
gs-4427	100	4	,	,	PUNCT
gs-4427	100	5	2025	2025	NUM
gs-4427	100	6	636	636	NUM
gs-4427	100	7	adaptive	adaptive	ADJ
gs-4427	100	8	immune	immune	ADJ
gs-4427	100	9	system	system	NOUN
gs-4427	100	10	,	,	PUNCT
gs-4427	100	11	crispr	crispr	NOUN
gs-4427	100	12	-	-	PUNCT
gs-4427	100	13	cas9	cas9	NOUN
gs-4427	100	14	enables	enable	VERB
gs-4427	100	15	precise	precise	ADJ
gs-4427	100	16	,	,	PUNCT
gs-4427	100	17	targeted	target	VERB
gs-4427	100	18	modifications	modification	NOUN
gs-4427	100	19	at	at	ADP
gs-4427	100	20	specific	specific	ADJ
gs-4427	100	21	genomic	genomic	NOUN
gs-4427	100	22	loci	locus	NOUN
gs-4427	100	23	through	through	ADP
gs-4427	100	24	programmable	programmable	ADJ
gs-4427	100	25	guide	guide	NOUN
gs-4427	100	26	rnas	rna	NOUN
gs-4427	100	27	directing	direct	VERB
gs-4427	100	28	the	the	DET
gs-4427	100	29	cas9	cas9	NOUN
gs-4427	100	30	nuclease	nuclease	NOUN
gs-4427	100	31	to	to	ADP
gs-4427	100	32	complementary	complementary	ADJ
gs-4427	100	33	dna	dna	PROPN
gs-4427	100	34	sequences	sequence	NOUN
gs-4427	100	35	.	.	PUNCT
gs-4427	101	1	this	this	DET
gs-4427	101	2	technology	technology	NOUN
gs-4427	101	3	enables	enable	VERB
gs-4427	101	4	diverse	diverse	ADJ
gs-4427	101	5	genetic	genetic	ADJ
gs-4427	101	6	modifications	modification	NOUN
gs-4427	101	7	including	include	VERB
gs-4427	101	8	gene	gene	NOUN
gs-4427	101	9	knockout	knockout	NOUN
gs-4427	101	10	through	through	ADP
gs-4427	101	11	non	non	ADJ
gs-4427	101	12	-	-	ADJ
gs-4427	101	13	homologous	homologous	ADJ
gs-4427	101	14	end	end	NOUN
gs-4427	101	15	joining	join	VERB
gs-4427	101	16	,	,	PUNCT
gs-4427	101	17	precise	precise	ADJ
gs-4427	101	18	correction	correction	NOUN
gs-4427	101	19	through	through	ADP
gs-4427	101	20	homology	homology	NOUN
gs-4427	101	21	-	-	PUNCT
gs-4427	101	22	directed	direct	VERB
gs-4427	101	23	repair	repair	NOUN
gs-4427	101	24	,	,	PUNCT
gs-4427	101	25	and	and	CCONJ
gs-4427	101	26	base	base	NOUN
gs-4427	101	27	-	-	PUNCT
gs-4427	101	28	level	level	NOUN
gs-4427	101	29	changes	change	NOUN
gs-4427	101	30	through	through	ADP
gs-4427	101	31	fusion	fusion	NOUN
gs-4427	101	32	with	with	ADP
gs-4427	101	33	deaminase	deaminase	NOUN
gs-4427	101	34	enzymes	enzyme	NOUN
gs-4427	101	35	.	.	PUNCT
gs-4427	102	1	the	the	DET
gs-4427	102	2	simplicity	simplicity	NOUN
gs-4427	102	3	,	,	PUNCT
gs-4427	102	4	versatility	versatility	NOUN
gs-4427	102	5	,	,	PUNCT
gs-4427	102	6	and	and	CCONJ
gs-4427	102	7	efficiency	efficiency	NOUN
gs-4427	102	8	of	of	ADP
gs-4427	102	9	crispr	crispr	NOUN
gs-4427	102	10	editing	edit	VERB
gs-4427	102	11	democratized	democratize	VERB
gs-4427	102	12	genome	genome	NOUN
gs-4427	102	13	engineering	engineering	NOUN
gs-4427	102	14	and	and	CCONJ
gs-4427	102	15	enabled	enable	VERB
gs-4427	102	16	applications	application	NOUN
gs-4427	102	17	previously	previously	ADV
gs-4427	102	18	impossible	impossible	ADJ
gs-4427	102	19	with	with	ADP
gs-4427	102	20	earlier	early	ADJ
gs-4427	102	21	technologies	technology	NOUN
gs-4427	102	22	such	such	ADJ
gs-4427	102	23	as	as	ADP
gs-4427	102	24	zinc	zinc	NOUN
gs-4427	102	25	finger	finger	NOUN
gs-4427	102	26	nucleases	nuclease	NOUN
gs-4427	102	27	and	and	CCONJ
gs-4427	102	28	transcription	transcription	NOUN
gs-4427	102	29	activator	activator	NOUN
gs-4427	102	30	-	-	PUNCT
gs-4427	102	31	like	like	ADJ
gs-4427	102	32	effector	effector	NOUN
gs-4427	102	33	nucleases	nuclease	NOUN
gs-4427	102	34	.	.	PUNCT
gs-4427	103	1	the	the	DET
gs-4427	103	2	rapid	rapid	ADJ
gs-4427	103	3	translation	translation	NOUN
gs-4427	103	4	of	of	ADP
gs-4427	103	5	crispr	crispr	ADJ
gs-4427	103	6	technology	technology	NOUN
gs-4427	103	7	from	from	ADP
gs-4427	103	8	basic	basic	ADJ
gs-4427	103	9	research	research	NOUN
gs-4427	103	10	tool	tool	NOUN
gs-4427	103	11	to	to	ADP
gs-4427	103	12	therapeutic	therapeutic	ADJ
gs-4427	103	13	modality	modality	NOUN
gs-4427	103	14	,	,	PUNCT
gs-4427	103	15	exemplified	exemplify	VERB
gs-4427	103	16	by	by	ADP
gs-4427	103	17	the	the	DET
gs-4427	103	18	approval	approval	NOUN
gs-4427	103	19	of	of	ADP
gs-4427	103	20	casgevy	casgevy	NOUN
gs-4427	103	21	less	less	ADJ
gs-4427	103	22	than	than	ADP
gs-4427	103	23	twelve	twelve	NUM
gs-4427	103	24	years	year	NOUN
gs-4427	103	25	after	after	ADP
gs-4427	103	26	the	the	DET
gs-4427	103	27	technology	technology	NOUN
gs-4427	103	28	's	's	PART
gs-4427	103	29	initial	initial	ADJ
gs-4427	103	30	description	description	NOUN
gs-4427	103	31	,	,	PUNCT
gs-4427	103	32	represents	represent	VERB
gs-4427	103	33	an	an	DET
gs-4427	103	34	unprecedented	unprecedented	ADJ
gs-4427	103	35	pace	pace	NOUN
gs-4427	103	36	of	of	ADP
gs-4427	103	37	clinical	clinical	ADJ
gs-4427	103	38	development	development	NOUN
gs-4427	103	39	.	.	PUNCT
gs-4427	104	1	concurrent	concurrent	ADJ
gs-4427	104	2	advances	advance	NOUN
gs-4427	104	3	in	in	ADP
gs-4427	104	4	cell	cell	NOUN
gs-4427	104	5	therapy	therapy	NOUN
gs-4427	104	6	manufacturing	manufacturing	NOUN
gs-4427	104	7	,	,	PUNCT
gs-4427	104	8	including	include	VERB
gs-4427	104	9	development	development	NOUN
gs-4427	104	10	of	of	ADP
gs-4427	104	11	closed	closed	ADJ
gs-4427	104	12	automated	automate	VERB
gs-4427	104	13	processing	processing	NOUN
gs-4427	104	14	systems	system	NOUN
gs-4427	104	15	,	,	PUNCT
gs-4427	104	16	implementation	implementation	NOUN
gs-4427	104	17	of	of	ADP
gs-4427	104	18	good	good	ADJ
gs-4427	104	19	manufacturing	manufacturing	NOUN
gs-4427	104	20	practice	practice	NOUN
gs-4427	104	21	protocols	protocol	NOUN
gs-4427	104	22	for	for	ADP
gs-4427	104	23	cell	cell	NOUN
gs-4427	104	24	manipulation	manipulation	NOUN
gs-4427	104	25	,	,	PUNCT
gs-4427	104	26	and	and	CCONJ
gs-4427	104	27	optimization	optimization	NOUN
gs-4427	104	28	of	of	ADP
gs-4427	104	29	cryopreservation	cryopreservation	NOUN
gs-4427	104	30	methods	method	NOUN
gs-4427	104	31	,	,	PUNCT
gs-4427	104	32	enabled	enable	VERB
gs-4427	104	33	scalable	scalable	ADJ
gs-4427	104	34	production	production	NOUN
gs-4427	104	35	of	of	ADP
gs-4427	104	36	engineered	engineer	VERB
gs-4427	104	37	cell	cell	NOUN
gs-4427	104	38	products	product	NOUN
gs-4427	104	39	.	.	PUNCT
gs-4427	105	1	the	the	DET
gs-4427	105	2	establishment	establishment	NOUN
gs-4427	105	3	of	of	ADP
gs-4427	105	4	specialized	specialized	ADJ
gs-4427	105	5	manufacturing	manufacturing	NOUN
gs-4427	105	6	facilities	facility	NOUN
gs-4427	105	7	,	,	PUNCT
gs-4427	105	8	development	development	NOUN
gs-4427	105	9	of	of	ADP
gs-4427	105	10	supply	supply	NOUN
gs-4427	105	11	chain	chain	NOUN
gs-4427	105	12	logistics	logistic	NOUN
gs-4427	105	13	for	for	ADP
gs-4427	105	14	temperature	temperature	NOUN
gs-4427	105	15	-	-	PUNCT
gs-4427	105	16	sensitive	sensitive	ADJ
gs-4427	105	17	biological	biological	ADJ
gs-4427	105	18	products	product	NOUN
gs-4427	105	19	,	,	PUNCT
gs-4427	105	20	and	and	CCONJ
gs-4427	105	21	creation	creation	NOUN
gs-4427	105	22	of	of	ADP
gs-4427	105	23	quality	quality	NOUN
gs-4427	105	24	control	control	NOUN
gs-4427	105	25	assays	assay	NOUN
gs-4427	105	26	for	for	ADP
gs-4427	105	27	characterizing	characterize	VERB
gs-4427	105	28	genetically	genetically	ADV
gs-4427	105	29	modified	modify	VERB
gs-4427	105	30	cells	cell	NOUN
gs-4427	105	31	transformed	transform	VERB
gs-4427	105	32	autologous	autologous	ADJ
gs-4427	105	33	cell	cell	NOUN
gs-4427	105	34	therapy	therapy	NOUN
gs-4427	105	35	from	from	ADP
gs-4427	105	36	small	small	ADJ
gs-4427	105	37	-	-	PUNCT
gs-4427	105	38	scale	scale	NOUN
gs-4427	105	39	academic	academic	ADJ
gs-4427	105	40	exercises	exercise	NOUN
gs-4427	105	41	to	to	ADP
gs-4427	105	42	commercially	commercially	ADV
gs-4427	105	43	viable	viable	VERB
gs-4427	105	44	therapeutic	therapeutic	ADJ
gs-4427	105	45	products	product	NOUN
gs-4427	105	46	.	.	PUNCT
gs-4427	106	1	these	these	DET
gs-4427	106	2	manufacturing	manufacturing	NOUN
gs-4427	106	3	innovations	innovation	NOUN
gs-4427	106	4	proved	prove	VERB
gs-4427	106	5	essential	essential	ADJ
gs-4427	106	6	for	for	ADP
gs-4427	106	7	car	car	NOUN
gs-4427	106	8	-	-	PUNCT
gs-4427	106	9	t	t	NOUN
gs-4427	106	10	cell	cell	NOUN
gs-4427	106	11	therapy	therapy	NOUN
gs-4427	106	12	development	development	NOUN
gs-4427	106	13	,	,	PUNCT
gs-4427	106	14	enabling	enable	VERB
gs-4427	106	15	consistent	consistent	ADJ
gs-4427	106	16	production	production	NOUN
gs-4427	106	17	of	of	ADP
gs-4427	106	18	complex	complex	ADJ
gs-4427	106	19	cellular	cellular	ADJ
gs-4427	106	20	products	product	NOUN
gs-4427	106	21	meeting	meet	VERB
gs-4427	106	22	regulatory	regulatory	ADJ
gs-4427	106	23	standards	standard	NOUN
gs-4427	106	24	for	for	ADP
gs-4427	106	25	safety	safety	NOUN
gs-4427	106	26	,	,	PUNCT
gs-4427	106	27	purity	purity	NOUN
gs-4427	106	28	,	,	PUNCT
gs-4427	106	29	and	and	CCONJ
gs-4427	106	30	potency	potency	NOUN
gs-4427	106	31	.	.	PUNCT
gs-4427	107	1	viral	viral	ADJ
gs-4427	107	2	vector	vector	NOUN
gs-4427	107	3	platforms	platform	NOUN
gs-4427	107	4	:	:	PUNCT
gs-4427	107	5	aav	aav	NOUN
gs-4427	107	6	and	and	CCONJ
gs-4427	107	7	lentiviral	lentiviral	ADJ
gs-4427	107	8	systems	system	NOUN
gs-4427	107	9	adeno	adeno	NOUN
gs-4427	107	10	-	-	PUNCT
gs-4427	107	11	associated	associate	VERB
gs-4427	107	12	virus	virus	NOUN
gs-4427	107	13	vectors	vector	NOUN
gs-4427	107	14	have	have	AUX
gs-4427	107	15	emerged	emerge	VERB
gs-4427	107	16	as	as	ADP
gs-4427	107	17	the	the	DET
gs-4427	107	18	dominant	dominant	ADJ
gs-4427	107	19	platform	platform	NOUN
gs-4427	107	20	for	for	ADP
gs-4427	107	21	in	in	ADP
gs-4427	107	22	vivo	vivo	ADJ
gs-4427	107	23	gene	gene	NOUN
gs-4427	107	24	therapy	therapy	NOUN
gs-4427	107	25	due	due	ADP
gs-4427	107	26	to	to	ADP
gs-4427	107	27	favorable	favorable	ADJ
gs-4427	107	28	biological	biological	ADJ
gs-4427	107	29	properties	property	NOUN
gs-4427	107	30	and	and	CCONJ
gs-4427	107	31	clinical	clinical	ADJ
gs-4427	107	32	track	track	NOUN
gs-4427	107	33	record	record	NOUN
gs-4427	107	34	.	.	PUNCT
gs-4427	108	1	aav	aav	NOUN
gs-4427	108	2	is	be	AUX
gs-4427	108	3	a	a	DET
gs-4427	108	4	small	small	ADJ
gs-4427	108	5	,	,	PUNCT
gs-4427	108	6	nonenveloped	nonenvelope	VERB
gs-4427	108	7	virus	virus	NOUN
gs-4427	108	8	naturally	naturally	ADV
gs-4427	108	9	infecting	infect	VERB
gs-4427	108	10	humans	human	NOUN
gs-4427	108	11	but	but	CCONJ
gs-4427	108	12	not	not	PART
gs-4427	108	13	causing	cause	VERB
gs-4427	108	14	known	known	ADJ
gs-4427	108	15	disease	disease	NOUN
gs-4427	108	16	,	,	PUNCT
gs-4427	108	17	making	make	VERB
gs-4427	108	18	it	it	PRON
gs-4427	108	19	an	an	DET
gs-4427	108	20	attractive	attractive	ADJ
gs-4427	108	21	therapeutic	therapeutic	ADJ
gs-4427	108	22	vector	vector	NOUN
gs-4427	108	23	with	with	ADP
gs-4427	108	24	inherent	inherent	ADJ
gs-4427	108	25	low	low	ADJ
gs-4427	108	26	pathogenicity	pathogenicity	NOUN
gs-4427	108	27	.	.	PUNCT
gs-4427	109	1	the	the	DET
gs-4427	109	2	discovery	discovery	NOUN
gs-4427	109	3	that	that	PRON
gs-4427	109	4	aav	aav	PROPN
gs-4427	109	5	vectors	vector	NOUN
gs-4427	109	6	primarily	primarily	ADV
gs-4427	109	7	remain	remain	VERB
gs-4427	109	8	episomal	episomal	ADJ
gs-4427	109	9	in	in	ADP
gs-4427	109	10	transduced	transduced	ADJ
gs-4427	109	11	cells	cell	NOUN
gs-4427	109	12	rather	rather	ADV
gs-4427	109	13	than	than	ADP
gs-4427	109	14	integrating	integrate	VERB
gs-4427	109	15	into	into	ADP
gs-4427	109	16	chromosomes	chromosome	NOUN
gs-4427	109	17	substantially	substantially	ADV
gs-4427	109	18	reduces	reduce	VERB
gs-4427	109	19	genotoxicity	genotoxicity	NOUN
gs-4427	109	20	risks	risk	NOUN
gs-4427	109	21	compared	compare	VERB
gs-4427	109	22	to	to	ADP
gs-4427	109	23	integrating	integrate	VERB
gs-4427	109	24	vectors	vector	NOUN
gs-4427	109	25	,	,	PUNCT
gs-4427	109	26	though	though	SCONJ
gs-4427	109	27	rare	rare	ADJ
gs-4427	109	28	integration	integration	NOUN
gs-4427	109	29	events	event	NOUN
gs-4427	109	30	can	can	AUX
gs-4427	109	31	occur	occur	VERB
gs-4427	109	32	.	.	PUNCT
gs-4427	110	1	the	the	DET
gs-4427	110	2	existence	existence	NOUN
gs-4427	110	3	of	of	ADP
gs-4427	110	4	numerous	numerous	ADJ
gs-4427	110	5	natural	natural	ADJ
gs-4427	110	6	aav	aav	NOUN
gs-4427	110	7	serotypes	serotype	NOUN
gs-4427	110	8	with	with	ADP
gs-4427	110	9	distinct	distinct	ADJ
gs-4427	110	10	tissue	tissue	NOUN
gs-4427	110	11	tropisms	tropism	NOUN
gs-4427	110	12	,	,	PUNCT
gs-4427	110	13	determined	determine	VERB
gs-4427	110	14	by	by	ADP
gs-4427	110	15	differences	difference	NOUN
gs-4427	110	16	in	in	ADP
gs-4427	110	17	capsid	capsid	ADJ
gs-4427	110	18	proteins	protein	NOUN
gs-4427	110	19	dictating	dictate	VERB
gs-4427	110	20	cell	cell	NOUN
gs-4427	110	21	surface	surface	NOUN
gs-4427	110	22	receptor	receptor	NOUN
gs-4427	110	23	interactions	interaction	NOUN
gs-4427	110	24	,	,	PUNCT
gs-4427	110	25	enables	enable	VERB
gs-4427	110	26	targeted	target	VERB
gs-4427	110	27	gene	gene	NOUN
gs-4427	110	28	delivery	delivery	NOUN
gs-4427	110	29	to	to	ADP
gs-4427	110	30	specific	specific	ADJ
gs-4427	110	31	organs	organ	NOUN
gs-4427	110	32	.	.	PUNCT
gs-4427	111	1	aav2	aav2	PROPN
gs-4427	111	2	demonstrates	demonstrate	VERB
gs-4427	111	3	efficient	efficient	ADJ
gs-4427	111	4	transduction	transduction	NOUN
gs-4427	111	5	of	of	ADP
gs-4427	111	6	retinal	retinal	ADJ
gs-4427	111	7	pigment	pigment	NOUN
gs-4427	111	8	epithelium	epithelium	NOUN
gs-4427	111	9	and	and	CCONJ
gs-4427	111	10	photoreceptors	photoreceptor	NOUN
gs-4427	111	11	,	,	PUNCT
gs-4427	111	12	making	make	VERB
gs-4427	111	13	it	it	PRON
gs-4427	111	14	ideal	ideal	ADJ
gs-4427	111	15	for	for	ADP
gs-4427	111	16	ocular	ocular	ADJ
gs-4427	111	17	gene	gene	NOUN
gs-4427	111	18	therapy	therapy	NOUN
gs-4427	111	19	as	as	SCONJ
gs-4427	111	20	demonstrated	demonstrate	VERB
gs-4427	111	21	by	by	ADP
gs-4427	111	22	luxturna	luxturna	NOUN
gs-4427	111	23	.	.	PUNCT
gs-4427	112	1	aav8	aav8	PROPN
gs-4427	112	2	and	and	CCONJ
gs-4427	112	3	aav9	aav9	PROPN
gs-4427	112	4	show	show	VERB
gs-4427	112	5	strong	strong	ADJ
gs-4427	112	6	hepatic	hepatic	ADJ
gs-4427	112	7	tropism	tropism	NOUN
gs-4427	112	8	enabling	enable	VERB
gs-4427	112	9	treatment	treatment	NOUN
gs-4427	112	10	of	of	ADP
gs-4427	112	11	liver	liver	NOUN
gs-4427	112	12	-	-	PUNCT
gs-4427	112	13	directed	direct	VERB
gs-4427	112	14	disorders	disorder	NOUN
gs-4427	112	15	including	include	VERB
gs-4427	112	16	hemophilia	hemophilia	PROPN
gs-4427	112	17	,	,	PUNCT
gs-4427	112	18	while	while	SCONJ
gs-4427	112	19	aav9	aav9	PROPN
gs-4427	112	20	crosses	cross	VERB
gs-4427	112	21	the	the	DET
gs-4427	112	22	blood	blood	NOUN
gs-4427	112	23	-	-	PUNCT
gs-4427	112	24	brain	brain	NOUN
gs-4427	112	25	barrier	barrier	NOUN
gs-4427	112	26	allowing	allow	VERB
gs-4427	112	27	central	central	ADJ
gs-4427	112	28	nervous	nervous	ADJ
gs-4427	112	29	system	system	NOUN
gs-4427	112	30	gene	gene	NOUN
gs-4427	112	31	delivery	delivery	NOUN
gs-4427	112	32	.	.	PUNCT
gs-4427	113	1	the	the	DET
gs-4427	113	2	clinical	clinical	ADJ
gs-4427	113	3	development	development	NOUN
gs-4427	113	4	of	of	ADP
gs-4427	113	5	aav	aav	NOUN
gs-4427	113	6	gene	gene	NOUN
gs-4427	113	7	therapies	therapy	NOUN
gs-4427	113	8	has	have	AUX
gs-4427	113	9	validated	validate	VERB
gs-4427	113	10	efficacy	efficacy	NOUN
gs-4427	113	11	across	across	ADP
gs-4427	113	12	diverse	diverse	ADJ
gs-4427	113	13	diseases	disease	NOUN
gs-4427	113	14	while	while	SCONJ
gs-4427	113	15	revealing	reveal	VERB
gs-4427	113	16	important	important	ADJ
gs-4427	113	17	limitations	limitation	NOUN
gs-4427	113	18	requiring	require	VERB
gs-4427	113	19	ongoing	ongoing	ADJ
gs-4427	113	20	innovation	innovation	NOUN
gs-4427	113	21	.	.	PUNCT
gs-4427	114	1	multiple	multiple	ADJ
gs-4427	114	2	georgian	georgian	NOUN
gs-4427	114	3	scientists/	scientists/	NUM
gs-4427	114	4	.	.	PUNCT
gs-4427	115	1	7	7	NUM
gs-4427	115	2	n	n	DET
gs-4427	115	3	4	4	NUM
gs-4427	115	4	,	,	PUNCT
gs-4427	115	5	2025	2025	NUM
gs-4427	115	6	637	637	NUM
gs-4427	115	7	aav	aav	NOUN
gs-4427	115	8	-	-	PUNCT
gs-4427	115	9	based	base	VERB
gs-4427	115	10	hemophilia	hemophilia	NOUN
gs-4427	115	11	gene	gene	NOUN
gs-4427	115	12	therapies	therapy	NOUN
gs-4427	115	13	have	have	AUX
gs-4427	115	14	demonstrated	demonstrate	VERB
gs-4427	115	15	sustained	sustained	ADJ
gs-4427	115	16	factor	factor	NOUN
gs-4427	115	17	viii	viii	NOUN
gs-4427	115	18	or	or	CCONJ
gs-4427	115	19	factor	factor	NOUN
gs-4427	115	20	ix	ix	NOUN
gs-4427	115	21	expression	expression	NOUN
gs-4427	115	22	following	follow	VERB
gs-4427	115	23	single	single	ADJ
gs-4427	115	24	intravenous	intravenous	ADJ
gs-4427	115	25	vector	vector	PROPN
gs-4427	115	26	administration	administration	NOUN
gs-4427	115	27	,	,	PUNCT
gs-4427	115	28	achieving	achieve	VERB
gs-4427	115	29	nearnormalization	nearnormalization	NOUN
gs-4427	115	30	of	of	ADP
gs-4427	115	31	clotting	clot	VERB
gs-4427	115	32	factor	factor	NOUN
gs-4427	115	33	levels	level	NOUN
gs-4427	115	34	in	in	ADP
gs-4427	115	35	many	many	ADJ
gs-4427	115	36	patients	patient	NOUN
gs-4427	115	37	and	and	CCONJ
gs-4427	115	38	dramatically	dramatically	ADV
gs-4427	115	39	reducing	reduce	VERB
gs-4427	115	40	bleeding	bleeding	NOUN
gs-4427	115	41	episodes	episode	NOUN
gs-4427	115	42	and	and	CCONJ
gs-4427	115	43	factor	factor	NOUN
gs-4427	115	44	replacement	replacement	NOUN
gs-4427	115	45	requirements	requirement	NOUN
gs-4427	115	46	(	(	PUNCT
gs-4427	115	47	kumar	kumar	PROPN
gs-4427	115	48	et	et	PROPN
gs-4427	115	49	al	al	PROPN
gs-4427	115	50	.	.	PROPN
gs-4427	115	51	,	,	PUNCT
gs-4427	115	52	2016	2016	NUM
gs-4427	115	53	)	)	PUNCT
gs-4427	115	54	.	.	PUNCT
gs-4427	116	1	durability	durability	NOUN
gs-4427	116	2	data	datum	NOUN
gs-4427	116	3	extending	extend	VERB
gs-4427	116	4	beyond	beyond	ADP
gs-4427	116	5	five	five	NUM
gs-4427	116	6	years	year	NOUN
gs-4427	116	7	for	for	ADP
gs-4427	116	8	some	some	DET
gs-4427	116	9	products	product	NOUN
gs-4427	116	10	demonstrate	demonstrate	VERB
gs-4427	116	11	stable	stable	ADJ
gs-4427	116	12	transgene	transgene	NOUN
gs-4427	116	13	expression	expression	NOUN
gs-4427	116	14	,	,	PUNCT
gs-4427	116	15	suggesting	suggest	VERB
gs-4427	116	16	potential	potential	NOUN
gs-4427	116	17	for	for	ADP
gs-4427	116	18	lifelong	lifelong	ADJ
gs-4427	116	19	therapeutic	therapeutic	ADJ
gs-4427	116	20	benefit	benefit	NOUN
gs-4427	116	21	from	from	ADP
gs-4427	116	22	single	single	ADJ
gs-4427	116	23	treatment	treatment	NOUN
gs-4427	116	24	.	.	PUNCT
gs-4427	117	1	however	however	ADV
gs-4427	117	2	,	,	PUNCT
gs-4427	117	3	progressive	progressive	ADJ
gs-4427	117	4	decline	decline	NOUN
gs-4427	117	5	in	in	ADP
gs-4427	117	6	transgene	transgene	ADJ
gs-4427	117	7	expression	expression	NOUN
gs-4427	117	8	observed	observe	VERB
gs-4427	117	9	in	in	ADP
gs-4427	117	10	some	some	DET
gs-4427	117	11	patients	patient	NOUN
gs-4427	117	12	,	,	PUNCT
gs-4427	117	13	attributed	attribute	VERB
gs-4427	117	14	to	to	ADP
gs-4427	117	15	immune	immune	NOUN
gs-4427	117	16	-	-	PUNCT
gs-4427	117	17	mediated	mediate	VERB
gs-4427	117	18	clearance	clearance	NOUN
gs-4427	117	19	of	of	ADP
gs-4427	117	20	transduced	transduce	VERB
gs-4427	117	21	hepatocytes	hepatocyte	NOUN
gs-4427	117	22	,	,	PUNCT
gs-4427	117	23	highlights	highlight	VERB
gs-4427	117	24	the	the	DET
gs-4427	117	25	need	need	NOUN
gs-4427	117	26	for	for	ADP
gs-4427	117	27	strategies	strategy	NOUN
gs-4427	117	28	enhancing	enhance	VERB
gs-4427	117	29	long	long	ADJ
gs-4427	117	30	-	-	PUNCT
gs-4427	117	31	term	term	NOUN
gs-4427	117	32	expression	expression	NOUN
gs-4427	117	33	including	include	VERB
gs-4427	117	34	immunosuppression	immunosuppression	NOUN
gs-4427	117	35	protocols	protocol	NOUN
gs-4427	117	36	and	and	CCONJ
gs-4427	117	37	novel	novel	ADJ
gs-4427	117	38	promoter	promoter	NOUN
gs-4427	117	39	designs	design	NOUN
gs-4427	117	40	.	.	PUNCT
gs-4427	118	1	pre	pre	ADJ
gs-4427	118	2	-	-	ADJ
gs-4427	118	3	existing	exist	VERB
gs-4427	118	4	neutralizing	neutralizing	ADJ
gs-4427	118	5	antibodies	antibody	NOUN
gs-4427	118	6	against	against	ADP
gs-4427	118	7	aav	aav	PROPN
gs-4427	118	8	capsids	capsid	NOUN
gs-4427	118	9	represent	represent	VERB
gs-4427	118	10	a	a	DET
gs-4427	118	11	significant	significant	ADJ
gs-4427	118	12	limitation	limitation	NOUN
gs-4427	118	13	,	,	PUNCT
gs-4427	118	14	rendering	render	VERB
gs-4427	118	15	30	30	NUM
gs-4427	118	16	-	-	SYM
gs-4427	118	17	50	50	NUM
gs-4427	118	18	%	%	NOUN
gs-4427	118	19	of	of	ADP
gs-4427	118	20	the	the	DET
gs-4427	118	21	population	population	NOUN
gs-4427	118	22	ineligible	ineligible	ADJ
gs-4427	118	23	for	for	ADP
gs-4427	118	24	treatment	treatment	NOUN
gs-4427	118	25	depending	depend	VERB
gs-4427	118	26	on	on	ADP
gs-4427	118	27	serotype	serotype	ADJ
gs-4427	118	28	and	and	CCONJ
gs-4427	118	29	antibody	antibody	NOUN
gs-4427	118	30	titer	titer	NOUN
gs-4427	118	31	thresholds	threshold	NOUN
gs-4427	118	32	.	.	PUNCT
gs-4427	119	1	these	these	DET
gs-4427	119	2	antibodies	antibodie	VERB
gs-4427	119	3	,	,	PUNCT
gs-4427	119	4	resulting	result	VERB
gs-4427	119	5	from	from	ADP
gs-4427	119	6	natural	natural	ADJ
gs-4427	119	7	aav	aav	PROPN
gs-4427	119	8	exposure	exposure	NOUN
gs-4427	119	9	throughout	throughout	ADP
gs-4427	119	10	childhood	childhood	NOUN
gs-4427	119	11	and	and	CCONJ
gs-4427	119	12	adulthood	adulthood	NOUN
gs-4427	119	13	,	,	PUNCT
gs-4427	119	14	block	block	NOUN
gs-4427	119	15	vector	vector	NOUN
gs-4427	119	16	transduction	transduction	NOUN
gs-4427	119	17	by	by	ADP
gs-4427	119	18	preventing	prevent	VERB
gs-4427	119	19	cellular	cellular	ADJ
gs-4427	119	20	uptake	uptake	NOUN
gs-4427	119	21	or	or	CCONJ
gs-4427	119	22	promoting	promote	VERB
gs-4427	119	23	vector	vector	NOUN
gs-4427	119	24	clearance	clearance	NOUN
gs-4427	119	25	.	.	PUNCT
gs-4427	120	1	while	while	SCONJ
gs-4427	120	2	patient	patient	ADJ
gs-4427	120	3	screening	screening	NOUN
gs-4427	120	4	enables	enable	VERB
gs-4427	120	5	identification	identification	NOUN
gs-4427	120	6	of	of	ADP
gs-4427	120	7	antibody	antibody	NOUN
gs-4427	120	8	-	-	PUNCT
gs-4427	120	9	negative	negative	ADJ
gs-4427	120	10	individuals	individual	NOUN
gs-4427	120	11	suitable	suitable	ADJ
gs-4427	120	12	for	for	ADP
gs-4427	120	13	treatment	treatment	NOUN
gs-4427	120	14	,	,	PUNCT
gs-4427	120	15	the	the	DET
gs-4427	120	16	substantial	substantial	ADJ
gs-4427	120	17	proportion	proportion	NOUN
gs-4427	120	18	of	of	ADP
gs-4427	120	19	excluded	exclude	VERB
gs-4427	120	20	patients	patient	NOUN
gs-4427	120	21	motivated	motivate	VERB
gs-4427	120	22	development	development	NOUN
gs-4427	120	23	of	of	ADP
gs-4427	120	24	strategies	strategy	NOUN
gs-4427	120	25	overcoming	overcome	VERB
gs-4427	120	26	antibody	antibody	NOUN
gs-4427	120	27	limitations	limitation	NOUN
gs-4427	120	28	including	include	VERB
gs-4427	120	29	plasmapheresis	plasmapheresis	NOUN
gs-4427	120	30	to	to	PART
gs-4427	120	31	remove	remove	VERB
gs-4427	120	32	circulating	circulate	VERB
gs-4427	120	33	antibodies	antibody	NOUN
gs-4427	120	34	,	,	PUNCT
gs-4427	120	35	use	use	NOUN
gs-4427	120	36	of	of	ADP
gs-4427	120	37	alternative	alternative	ADJ
gs-4427	120	38	serotypes	serotype	NOUN
gs-4427	120	39	with	with	ADP
gs-4427	120	40	lower	low	ADJ
gs-4427	120	41	seroprevalence	seroprevalence	NOUN
gs-4427	120	42	,	,	PUNCT
gs-4427	120	43	and	and	CCONJ
gs-4427	120	44	engineering	engineering	NOUN
gs-4427	120	45	of	of	ADP
gs-4427	120	46	capsid	capsid	ADJ
gs-4427	120	47	variants	variant	NOUN
gs-4427	120	48	with	with	ADP
gs-4427	120	49	altered	altered	ADJ
gs-4427	120	50	antigenic	antigenic	ADJ
gs-4427	120	51	profiles	profile	NOUN
gs-4427	120	52	.	.	PUNCT
gs-4427	121	1	the	the	DET
gs-4427	121	2	inability	inability	NOUN
gs-4427	121	3	to	to	PART
gs-4427	121	4	re	re	VERB
gs-4427	121	5	-	-	VERB
gs-4427	121	6	dose	dose	VERB
gs-4427	121	7	with	with	ADP
gs-4427	121	8	the	the	DET
gs-4427	121	9	same	same	ADJ
gs-4427	121	10	serotype	serotype	NOUN
gs-4427	121	11	due	due	ADP
gs-4427	121	12	to	to	ADP
gs-4427	121	13	development	development	NOUN
gs-4427	121	14	of	of	ADP
gs-4427	121	15	potent	potent	ADJ
gs-4427	121	16	neutralizing	neutralizing	ADJ
gs-4427	121	17	antibodies	antibody	NOUN
gs-4427	121	18	following	follow	VERB
gs-4427	121	19	initial	initial	ADJ
gs-4427	121	20	vector	vector	NOUN
gs-4427	121	21	administration	administration	NOUN
gs-4427	121	22	further	far	ADV
gs-4427	121	23	constrains	constrain	VERB
gs-4427	121	24	therapeutic	therapeutic	ADJ
gs-4427	121	25	flexibility	flexibility	NOUN
gs-4427	121	26	,	,	PUNCT
gs-4427	121	27	though	though	SCONJ
gs-4427	121	28	use	use	NOUN
gs-4427	121	29	of	of	ADP
gs-4427	121	30	different	different	ADJ
gs-4427	121	31	serotypes	serotype	NOUN
gs-4427	121	32	for	for	ADP
gs-4427	121	33	subsequent	subsequent	ADJ
gs-4427	121	34	dosing	dosing	NOUN
gs-4427	121	35	or	or	CCONJ
gs-4427	121	36	immunosuppression	immunosuppression	NOUN
gs-4427	121	37	regimens	regimen	NOUN
gs-4427	121	38	enabling	enable	VERB
gs-4427	121	39	re	re	NOUN
gs-4427	121	40	-	-	NOUN
gs-4427	121	41	administration	administration	NOUN
gs-4427	121	42	represent	represent	VERB
gs-4427	121	43	potential	potential	ADJ
gs-4427	121	44	solutions	solution	NOUN
gs-4427	121	45	.	.	PUNCT
gs-4427	122	1	lentiviral	lentiviral	ADJ
gs-4427	122	2	vectors	vector	NOUN
gs-4427	122	3	have	have	AUX
gs-4427	122	4	become	become	VERB
gs-4427	122	5	the	the	DET
gs-4427	122	6	preferred	prefer	VERB
gs-4427	122	7	platform	platform	NOUN
gs-4427	122	8	for	for	ADP
gs-4427	122	9	ex	ex	PRON
gs-4427	122	10	vivo	vivo	NOUN
gs-4427	122	11	gene	gene	NOUN
gs-4427	122	12	therapy	therapy	NOUN
gs-4427	122	13	applications	application	NOUN
gs-4427	122	14	requiring	require	VERB
gs-4427	122	15	stable	stable	ADJ
gs-4427	122	16	genomic	genomic	NOUN
gs-4427	122	17	integration	integration	NOUN
gs-4427	122	18	to	to	PART
gs-4427	122	19	ensure	ensure	VERB
gs-4427	122	20	transgene	transgene	ADJ
gs-4427	122	21	maintenance	maintenance	NOUN
gs-4427	122	22	through	through	ADP
gs-4427	122	23	cell	cell	NOUN
gs-4427	122	24	division	division	NOUN
gs-4427	122	25	.	.	PUNCT
gs-4427	123	1	derived	derive	VERB
gs-4427	123	2	from	from	ADP
gs-4427	123	3	hiv-1	hiv-1	PUNCT
gs-4427	123	4	but	but	CCONJ
gs-4427	123	5	extensively	extensively	ADV
gs-4427	123	6	modified	modify	VERB
gs-4427	123	7	for	for	ADP
gs-4427	123	8	safety	safety	NOUN
gs-4427	123	9	,	,	PUNCT
gs-4427	123	10	clinical	clinical	ADJ
gs-4427	123	11	-	-	PUNCT
gs-4427	123	12	grade	grade	NOUN
gs-4427	123	13	lentiviral	lentiviral	ADJ
gs-4427	123	14	vectors	vector	NOUN
gs-4427	123	15	lack	lack	VERB
gs-4427	123	16	all	all	DET
gs-4427	123	17	viral	viral	ADJ
gs-4427	123	18	genes	gene	NOUN
gs-4427	123	19	required	require	VERB
gs-4427	123	20	for	for	ADP
gs-4427	123	21	replication	replication	NOUN
gs-4427	123	22	,	,	PUNCT
gs-4427	123	23	utilize	utilize	VERB
gs-4427	123	24	heterologous	heterologous	ADJ
gs-4427	123	25	envelope	envelope	NOUN
gs-4427	123	26	proteins	protein	NOUN
gs-4427	123	27	preventing	prevent	VERB
gs-4427	123	28	tropism	tropism	NOUN
gs-4427	123	29	for	for	ADP
gs-4427	123	30	human	human	ADJ
gs-4427	123	31	cells	cell	NOUN
gs-4427	123	32	,	,	PUNCT
gs-4427	123	33	and	and	CCONJ
gs-4427	123	34	incorporate	incorporate	VERB
gs-4427	123	35	self	self	NOUN
gs-4427	123	36	-	-	PUNCT
gs-4427	123	37	inactivating	inactivate	VERB
gs-4427	123	38	modifications	modification	NOUN
gs-4427	123	39	eliminating	eliminate	VERB
gs-4427	123	40	transcriptional	transcriptional	ADJ
gs-4427	123	41	activity	activity	NOUN
gs-4427	123	42	from	from	ADP
gs-4427	123	43	long	long	ADJ
gs-4427	123	44	terminal	terminal	ADJ
gs-4427	123	45	repeats	repeat	NOUN
gs-4427	123	46	.	.	PUNCT
gs-4427	124	1	these	these	DET
gs-4427	124	2	safety	safety	NOUN
gs-4427	124	3	features	feature	NOUN
gs-4427	124	4	,	,	PUNCT
gs-4427	124	5	combined	combine	VERB
gs-4427	124	6	with	with	ADP
gs-4427	124	7	the	the	DET
gs-4427	124	8	ability	ability	NOUN
gs-4427	124	9	to	to	PART
gs-4427	124	10	accommodate	accommodate	VERB
gs-4427	124	11	relatively	relatively	ADV
gs-4427	124	12	large	large	ADJ
gs-4427	124	13	transgenes	transgene	NOUN
gs-4427	124	14	exceeding	exceed	VERB
gs-4427	124	15	8	8	NUM
gs-4427	124	16	kilobases	kilobase	NOUN
gs-4427	124	17	and	and	CCONJ
gs-4427	124	18	efficiently	efficiently	ADV
gs-4427	124	19	transduce	transduce	VERB
gs-4427	124	20	both	both	CCONJ
gs-4427	124	21	dividing	dividing	NOUN
gs-4427	124	22	and	and	CCONJ
gs-4427	124	23	non	non	ADJ
gs-4427	124	24	-	-	ADJ
gs-4427	124	25	dividing	dividing	ADJ
gs-4427	124	26	cells	cell	NOUN
gs-4427	124	27	,	,	PUNCT
gs-4427	124	28	make	make	VERB
gs-4427	124	29	lentiviral	lentiviral	ADJ
gs-4427	124	30	vectors	vector	NOUN
gs-4427	124	31	particularly	particularly	ADV
gs-4427	124	32	suitable	suitable	ADJ
gs-4427	124	33	for	for	ADP
gs-4427	124	34	hematopoietic	hematopoietic	ADJ
gs-4427	124	35	stem	stem	NOUN
gs-4427	124	36	cell	cell	NOUN
gs-4427	124	37	gene	gene	NOUN
gs-4427	124	38	therapy	therapy	NOUN
gs-4427	124	39	and	and	CCONJ
gs-4427	124	40	car	car	NOUN
gs-4427	124	41	-	-	PUNCT
gs-4427	124	42	t	t	NOUN
gs-4427	124	43	cell	cell	NOUN
gs-4427	124	44	manufacturing	manufacturing	NOUN
gs-4427	124	45	.	.	PUNCT
gs-4427	125	1	the	the	DET
gs-4427	125	2	use	use	NOUN
gs-4427	125	3	of	of	ADP
gs-4427	125	4	lentiviral	lentiviral	ADJ
gs-4427	125	5	vectors	vector	NOUN
gs-4427	125	6	in	in	ADP
gs-4427	125	7	multiple	multiple	ADJ
gs-4427	125	8	approved	approve	VERB
gs-4427	125	9	products	product	NOUN
gs-4427	125	10	including	include	VERB
gs-4427	125	11	casgevy	casgevy	NOUN
gs-4427	125	12	,	,	PUNCT
gs-4427	125	13	lyfgenia	lyfgenia	NOUN
gs-4427	125	14	,	,	PUNCT
gs-4427	125	15	and	and	CCONJ
gs-4427	125	16	all	all	DET
gs-4427	125	17	commercial	commercial	ADJ
gs-4427	125	18	car	car	NOUN
gs-4427	125	19	-	-	PUNCT
gs-4427	125	20	t	t	NOUN
gs-4427	125	21	therapies	therapy	NOUN
gs-4427	125	22	demonstrates	demonstrate	VERB
gs-4427	125	23	their	their	PRON
gs-4427	125	24	clinical	clinical	ADJ
gs-4427	125	25	viability	viability	NOUN
gs-4427	125	26	and	and	CCONJ
gs-4427	125	27	regulatory	regulatory	ADJ
gs-4427	125	28	acceptance	acceptance	NOUN
gs-4427	125	29	.	.	PUNCT
gs-4427	126	1	clinical	clinical	ADJ
gs-4427	126	2	success	success	NOUN
gs-4427	126	3	in	in	ADP
gs-4427	126	4	monogenic	monogenic	ADJ
gs-4427	126	5	blood	blood	NOUN
gs-4427	126	6	disorders	disorder	NOUN
gs-4427	126	7	monogenic	monogenic	ADJ
gs-4427	126	8	blood	blood	NOUN
gs-4427	126	9	disorders	disorder	NOUN
gs-4427	126	10	affecting	affect	VERB
gs-4427	126	11	hematopoietic	hematopoietic	ADJ
gs-4427	126	12	lineages	lineage	NOUN
gs-4427	126	13	represent	represent	VERB
gs-4427	126	14	an	an	DET
gs-4427	126	15	optimal	optimal	ADJ
gs-4427	126	16	initial	initial	ADJ
gs-4427	126	17	target	target	NOUN
gs-4427	126	18	for	for	ADP
gs-4427	126	19	gene	gene	NOUN
gs-4427	126	20	therapy	therapy	NOUN
gs-4427	126	21	due	due	ADP
gs-4427	126	22	to	to	ADP
gs-4427	126	23	accessible	accessible	ADJ
gs-4427	126	24	target	target	NOUN
gs-4427	126	25	tissues	tissue	NOUN
gs-4427	126	26	,	,	PUNCT
gs-4427	126	27	well	well	ADV
gs-4427	126	28	-	-	PUNCT
gs-4427	126	29	characterized	characterize	VERB
gs-4427	126	30	disease	disease	NOUN
gs-4427	126	31	genetics	genetic	NOUN
gs-4427	126	32	,	,	PUNCT
gs-4427	126	33	georgian	georgian	NOUN
gs-4427	126	34	scientists/	scientists/	NUM
gs-4427	126	35	.	.	PUNCT
gs-4427	127	1	7	7	NUM
gs-4427	127	2	n	n	DET
gs-4427	127	3	4	4	NUM
gs-4427	127	4	,	,	PUNCT
gs-4427	127	5	2025	2025	NUM
gs-4427	127	6	638	638	NUM
gs-4427	127	7	established	establish	VERB
gs-4427	127	8	transplantation	transplantation	NOUN
gs-4427	127	9	expertise	expertise	NOUN
gs-4427	127	10	enabling	enable	VERB
gs-4427	127	11	engraftment	engraftment	NOUN
gs-4427	127	12	of	of	ADP
gs-4427	127	13	gene	gene	NOUN
gs-4427	127	14	-	-	PUNCT
gs-4427	127	15	modified	modify	VERB
gs-4427	127	16	cells	cell	NOUN
gs-4427	127	17	,	,	PUNCT
gs-4427	127	18	and	and	CCONJ
gs-4427	127	19	severe	severe	ADJ
gs-4427	127	20	disease	disease	NOUN
gs-4427	127	21	burden	burden	NOUN
gs-4427	127	22	justifying	justify	VERB
gs-4427	127	23	innovative	innovative	ADJ
gs-4427	127	24	therapeutic	therapeutic	ADJ
gs-4427	127	25	approaches	approach	NOUN
gs-4427	127	26	.	.	PUNCT
gs-4427	128	1	sickle	sickle	NOUN
gs-4427	128	2	cell	cell	NOUN
gs-4427	128	3	disease	disease	PROPN
gs-4427	128	4	,	,	PUNCT
gs-4427	128	5	caused	cause	VERB
gs-4427	128	6	by	by	ADP
gs-4427	128	7	a	a	DET
gs-4427	128	8	single	single	ADJ
gs-4427	128	9	point	point	NOUN
gs-4427	128	10	mutation	mutation	NOUN
gs-4427	128	11	in	in	ADP
gs-4427	128	12	the	the	DET
gs-4427	128	13	beta	beta	NOUN
gs-4427	128	14	-	-	PUNCT
gs-4427	128	15	globin	globin	NOUN
gs-4427	128	16	gene	gene	NOUN
gs-4427	128	17	resulting	result	VERB
gs-4427	128	18	in	in	ADP
gs-4427	128	19	production	production	NOUN
gs-4427	128	20	of	of	ADP
gs-4427	128	21	abnormal	abnormal	ADJ
gs-4427	128	22	hemoglobin	hemoglobin	NOUN
gs-4427	128	23	that	that	PRON
gs-4427	128	24	polymerizes	polymerize	VERB
gs-4427	128	25	under	under	ADP
gs-4427	128	26	deoxygenated	deoxygenate	VERB
gs-4427	128	27	conditions	condition	NOUN
gs-4427	128	28	causing	cause	VERB
gs-4427	128	29	erythrocyte	erythrocyte	NOUN
gs-4427	128	30	sickling	sickling	NOUN
gs-4427	128	31	,	,	PUNCT
gs-4427	128	32	affects	affect	VERB
gs-4427	128	33	approximately	approximately	ADV
gs-4427	128	34	100,000	100,000	NUM
gs-4427	128	35	individuals	individual	NOUN
gs-4427	128	36	in	in	ADP
gs-4427	128	37	the	the	DET
gs-4427	128	38	united	united	PROPN
gs-4427	128	39	states	states	PROPN
gs-4427	128	40	and	and	CCONJ
gs-4427	128	41	millions	million	NOUN
gs-4427	128	42	globally	globally	ADV
gs-4427	128	43	,	,	PUNCT
gs-4427	128	44	predominantly	predominantly	ADV
gs-4427	128	45	among	among	ADP
gs-4427	128	46	populations	population	NOUN
gs-4427	128	47	of	of	ADP
gs-4427	128	48	african	african	ADJ
gs-4427	128	49	,	,	PUNCT
gs-4427	128	50	mediterranean	mediterranean	PROPN
gs-4427	128	51	,	,	PUNCT
gs-4427	128	52	and	and	CCONJ
gs-4427	128	53	middle	middle	ADJ
gs-4427	128	54	eastern	eastern	ADJ
gs-4427	128	55	ancestry	ancestry	NOUN
gs-4427	128	56	.	.	PUNCT
gs-4427	129	1	the	the	DET
gs-4427	129	2	disease	disease	NOUN
gs-4427	129	3	manifests	manifest	VERB
gs-4427	129	4	through	through	ADP
gs-4427	129	5	recurrent	recurrent	ADJ
gs-4427	129	6	painful	painful	ADJ
gs-4427	129	7	vaso	vaso	NOUN
gs-4427	129	8	-	-	PUNCT
gs-4427	129	9	occlusive	occlusive	ADJ
gs-4427	129	10	crises	crisis	NOUN
gs-4427	129	11	,	,	PUNCT
gs-4427	129	12	progressive	progressive	ADJ
gs-4427	129	13	organ	organ	NOUN
gs-4427	129	14	damage	damage	NOUN
gs-4427	129	15	,	,	PUNCT
gs-4427	129	16	increased	increase	VERB
gs-4427	129	17	infection	infection	NOUN
gs-4427	129	18	susceptibility	susceptibility	NOUN
gs-4427	129	19	,	,	PUNCT
gs-4427	129	20	and	and	CCONJ
gs-4427	129	21	reduced	reduce	VERB
gs-4427	129	22	life	life	NOUN
gs-4427	129	23	expectancy	expectancy	NOUN
gs-4427	129	24	.	.	PUNCT
gs-4427	130	1	while	while	SCONJ
gs-4427	130	2	hematopoietic	hematopoietic	ADJ
gs-4427	130	3	stem	stem	NOUN
gs-4427	130	4	cell	cell	NOUN
gs-4427	130	5	transplantation	transplantation	NOUN
gs-4427	130	6	can	can	AUX
gs-4427	130	7	cure	cure	VERB
gs-4427	130	8	sickle	sickle	NOUN
gs-4427	130	9	cell	cell	NOUN
gs-4427	130	10	disease	disease	NOUN
gs-4427	130	11	,	,	PUNCT
gs-4427	130	12	donor	donor	NOUN
gs-4427	130	13	availability	availability	NOUN
gs-4427	130	14	limitations	limitation	NOUN
gs-4427	130	15	and	and	CCONJ
gs-4427	130	16	transplant	transplant	NOUN
gs-4427	130	17	-	-	PUNCT
gs-4427	130	18	related	relate	VERB
gs-4427	130	19	risks	risk	NOUN
gs-4427	130	20	including	include	VERB
gs-4427	130	21	graft	graft	NOUN
gs-4427	130	22	failure	failure	NOUN
gs-4427	130	23	and	and	CCONJ
gs-4427	130	24	chronic	chronic	ADJ
gs-4427	130	25	graftversus	graftversus	NOUN
gs-4427	130	26	-	-	PUNCT
gs-4427	130	27	host	host	NOUN
gs-4427	130	28	disease	disease	NOUN
gs-4427	130	29	restrict	restrict	VERB
gs-4427	130	30	this	this	DET
gs-4427	130	31	option	option	NOUN
gs-4427	130	32	to	to	ADP
gs-4427	130	33	a	a	DET
gs-4427	130	34	minority	minority	NOUN
gs-4427	130	35	of	of	ADP
gs-4427	130	36	patients	patient	NOUN
gs-4427	130	37	.	.	PUNCT
gs-4427	131	1	gene	gene	NOUN
gs-4427	131	2	therapy	therapy	NOUN
gs-4427	131	3	approaches	approach	VERB
gs-4427	131	4	for	for	ADP
gs-4427	131	5	sickle	sickle	NOUN
gs-4427	131	6	cell	cell	NOUN
gs-4427	131	7	disease	disease	NOUN
gs-4427	131	8	have	have	AUX
gs-4427	131	9	pursued	pursue	VERB
gs-4427	131	10	two	two	NUM
gs-4427	131	11	primary	primary	ADJ
gs-4427	131	12	strategies	strategy	NOUN
gs-4427	131	13	:	:	PUNCT
gs-4427	131	14	addition	addition	NOUN
gs-4427	131	15	of	of	ADP
gs-4427	131	16	a	a	DET
gs-4427	131	17	functional	functional	ADJ
gs-4427	131	18	beta	beta	NOUN
gs-4427	131	19	-	-	PUNCT
gs-4427	131	20	globin	globin	NOUN
gs-4427	131	21	or	or	CCONJ
gs-4427	131	22	anti	anti	ADJ
gs-4427	131	23	-	-	ADJ
gs-4427	131	24	sickling	sickling	ADJ
gs-4427	131	25	beta	beta	NOUN
gs-4427	131	26	-	-	PUNCT
gs-4427	131	27	globin	globin	NOUN
gs-4427	131	28	variant	variant	NOUN
gs-4427	131	29	to	to	PART
gs-4427	131	30	overcome	overcome	VERB
gs-4427	131	31	the	the	DET
gs-4427	131	32	defective	defective	ADJ
gs-4427	131	33	endogenous	endogenous	ADJ
gs-4427	131	34	gene	gene	NOUN
gs-4427	131	35	,	,	PUNCT
gs-4427	131	36	or	or	CCONJ
gs-4427	131	37	reactivation	reactivation	NOUN
gs-4427	131	38	of	of	ADP
gs-4427	131	39	fetal	fetal	ADJ
gs-4427	131	40	hemoglobin	hemoglobin	NOUN
gs-4427	131	41	expression	expression	NOUN
gs-4427	131	42	which	which	PRON
gs-4427	131	43	naturally	naturally	ADV
gs-4427	131	44	ameliorates	ameliorate	VERB
gs-4427	131	45	disease	disease	NOUN
gs-4427	131	46	manifestations	manifestation	NOUN
gs-4427	131	47	.	.	PUNCT
gs-4427	132	1	lyfgenia	lyfgenia	PROPN
gs-4427	132	2	employs	employ	VERB
gs-4427	132	3	a	a	DET
gs-4427	132	4	lentiviral	lentiviral	ADJ
gs-4427	132	5	vector	vector	NOUN
gs-4427	132	6	encoding	encode	VERB
gs-4427	132	7	a	a	DET
gs-4427	132	8	modified	modify	VERB
gs-4427	132	9	beta	beta	NOUN
gs-4427	132	10	-	-	PUNCT
gs-4427	132	11	globin	globin	NOUN
gs-4427	132	12	gene	gene	NOUN
gs-4427	132	13	(	(	PUNCT
gs-4427	132	14	beta	beta	NOUN
gs-4427	132	15	-	-	PUNCT
gs-4427	132	16	a	a	DET
gs-4427	132	17	-	-	PUNCT
gs-4427	132	18	t87q	t87q	NOUN
gs-4427	132	19	-	-	PUNCT
gs-4427	132	20	globin	globin	NOUN
gs-4427	132	21	)	)	PUNCT
gs-4427	132	22	with	with	ADP
gs-4427	132	23	increased	increase	VERB
gs-4427	132	24	anti	anti	ADJ
gs-4427	132	25	-	-	ADJ
gs-4427	132	26	sickling	sickling	ADJ
gs-4427	132	27	properties	property	NOUN
gs-4427	132	28	,	,	PUNCT
gs-4427	132	29	transducing	transduce	VERB
gs-4427	132	30	autologous	autologous	ADJ
gs-4427	132	31	cd34	cd34	PROPN
gs-4427	132	32	-	-	PUNCT
gs-4427	132	33	positive	positive	ADJ
gs-4427	132	34	hematopoietic	hematopoietic	ADJ
gs-4427	132	35	stem	stem	NOUN
gs-4427	132	36	cells	cell	NOUN
gs-4427	132	37	ex	ex	X
gs-4427	132	38	vivo	vivo	VERB
gs-4427	132	39	before	before	ADP
gs-4427	132	40	reinfusion	reinfusion	NOUN
gs-4427	132	41	following	follow	VERB
gs-4427	132	42	myeloablative	myeloablative	ADJ
gs-4427	132	43	conditioning	conditioning	NOUN
gs-4427	132	44	(	(	PUNCT
gs-4427	132	45	rahmat	rahmat	NOUN
gs-4427	132	46	et	et	PROPN
gs-4427	132	47	al	al	PROPN
gs-4427	132	48	.	.	PROPN
gs-4427	132	49	,	,	PUNCT
gs-4427	132	50	2024	2024	NUM
gs-4427	132	51	)	)	PUNCT
gs-4427	132	52	.	.	PUNCT
gs-4427	133	1	clinical	clinical	ADJ
gs-4427	133	2	trial	trial	NOUN
gs-4427	133	3	results	result	NOUN
gs-4427	133	4	demonstrated	demonstrate	VERB
gs-4427	133	5	that	that	SCONJ
gs-4427	133	6	vector	vector	NOUN
gs-4427	133	7	-	-	PUNCT
gs-4427	133	8	derived	derive	VERB
gs-4427	133	9	anti	anti	ADJ
gs-4427	133	10	-	-	ADJ
gs-4427	133	11	sickling	sickling	ADJ
gs-4427	133	12	hemoglobin	hemoglobin	NOUN
gs-4427	133	13	comprised	comprise	VERB
gs-4427	133	14	20	20	NUM
gs-4427	133	15	-	-	SYM
gs-4427	133	16	40	40	NUM
gs-4427	133	17	%	%	NOUN
gs-4427	133	18	of	of	ADP
gs-4427	133	19	total	total	ADJ
gs-4427	133	20	hemoglobin	hemoglobin	NOUN
gs-4427	133	21	in	in	ADP
gs-4427	133	22	most	most	ADJ
gs-4427	133	23	patients	patient	NOUN
gs-4427	133	24	,	,	PUNCT
gs-4427	133	25	sufficient	sufficient	ADJ
gs-4427	133	26	to	to	PART
gs-4427	133	27	eliminate	eliminate	VERB
gs-4427	133	28	or	or	CCONJ
gs-4427	133	29	dramatically	dramatically	ADV
gs-4427	133	30	reduce	reduce	VERB
gs-4427	133	31	vaso	vaso	NOUN
gs-4427	133	32	-	-	PUNCT
gs-4427	133	33	occlusive	occlusive	ADJ
gs-4427	133	34	crises	crisis	NOUN
gs-4427	133	35	and	and	CCONJ
gs-4427	133	36	enable	enable	VERB
gs-4427	133	37	discontinuation	discontinuation	NOUN
gs-4427	133	38	of	of	ADP
gs-4427	133	39	chronic	chronic	ADJ
gs-4427	133	40	transfusion	transfusion	NOUN
gs-4427	133	41	therapy	therapy	NOUN
gs-4427	133	42	in	in	ADP
gs-4427	133	43	the	the	DET
gs-4427	133	44	majority	majority	NOUN
gs-4427	133	45	of	of	ADP
gs-4427	133	46	treated	treat	VERB
gs-4427	133	47	individuals	individual	NOUN
gs-4427	133	48	.	.	PUNCT
gs-4427	134	1	long	long	ADJ
gs-4427	134	2	-	-	PUNCT
gs-4427	134	3	term	term	NOUN
gs-4427	134	4	follow	follow	NOUN
gs-4427	134	5	-	-	PUNCT
gs-4427	134	6	up	up	NOUN
gs-4427	134	7	through	through	ADP
gs-4427	134	8	three	three	NUM
gs-4427	134	9	years	year	NOUN
gs-4427	134	10	post	post	ADJ
gs-4427	134	11	-	-	ADJ
gs-4427	134	12	treatment	treatment	ADJ
gs-4427	134	13	shows	show	NOUN
gs-4427	134	14	maintained	maintain	VERB
gs-4427	134	15	therapeutic	therapeutic	ADJ
gs-4427	134	16	hemoglobin	hemoglobin	NOUN
gs-4427	134	17	levels	level	NOUN
gs-4427	134	18	and	and	CCONJ
gs-4427	134	19	sustained	sustain	VERB
gs-4427	134	20	clinical	clinical	ADJ
gs-4427	134	21	benefits	benefit	NOUN
gs-4427	134	22	in	in	ADP
gs-4427	134	23	most	most	ADJ
gs-4427	134	24	patients	patient	NOUN
gs-4427	134	25	.	.	PUNCT
gs-4427	135	1	casgevy	casgevy	NOUN
gs-4427	135	2	represents	represent	VERB
gs-4427	135	3	an	an	DET
gs-4427	135	4	alternative	alternative	ADJ
gs-4427	135	5	approach	approach	NOUN
gs-4427	135	6	employing	employ	VERB
gs-4427	135	7	crispr	crispr	NOUN
gs-4427	135	8	-	-	PUNCT
gs-4427	135	9	cas9	cas9	NOUN
gs-4427	135	10	editing	editing	NOUN
gs-4427	135	11	to	to	PART
gs-4427	135	12	disrupt	disrupt	VERB
gs-4427	135	13	the	the	DET
gs-4427	135	14	bcl11a	bcl11a	X
gs-4427	135	15	erythroid	erythroid	ADJ
gs-4427	135	16	-	-	PUNCT
gs-4427	135	17	specific	specific	ADJ
gs-4427	135	18	enhancer	enhancer	NOUN
gs-4427	135	19	in	in	ADP
gs-4427	135	20	hematopoietic	hematopoietic	ADJ
gs-4427	135	21	stem	stem	NOUN
gs-4427	135	22	cells	cell	NOUN
gs-4427	135	23	,	,	PUNCT
gs-4427	135	24	leading	lead	VERB
gs-4427	135	25	to	to	ADP
gs-4427	135	26	reactivation	reactivation	NOUN
gs-4427	135	27	of	of	ADP
gs-4427	135	28	fetal	fetal	ADJ
gs-4427	135	29	hemoglobin	hemoglobin	NOUN
gs-4427	135	30	production	production	NOUN
gs-4427	135	31	.	.	PUNCT
gs-4427	136	1	bcl11a	bcl11a	X
gs-4427	136	2	is	be	AUX
gs-4427	136	3	a	a	DET
gs-4427	136	4	transcriptional	transcriptional	ADJ
gs-4427	136	5	repressor	repressor	NOUN
gs-4427	136	6	that	that	PRON
gs-4427	136	7	normally	normally	ADV
gs-4427	136	8	silences	silence	VERB
gs-4427	136	9	fetal	fetal	ADJ
gs-4427	136	10	hemoglobin	hemoglobin	NOUN
gs-4427	136	11	genes	gene	NOUN
gs-4427	136	12	during	during	ADP
gs-4427	136	13	the	the	DET
gs-4427	136	14	transition	transition	NOUN
gs-4427	136	15	from	from	ADP
gs-4427	136	16	fetal	fetal	ADJ
gs-4427	136	17	to	to	ADP
gs-4427	136	18	adult	adult	NOUN
gs-4427	136	19	erythropoiesis	erythropoiesis	NOUN
gs-4427	136	20	;	;	PUNCT
gs-4427	136	21	disruption	disruption	NOUN
gs-4427	136	22	of	of	ADP
gs-4427	136	23	its	its	PRON
gs-4427	136	24	erythroid	erythroid	ADJ
gs-4427	136	25	-	-	PUNCT
gs-4427	136	26	specific	specific	ADJ
gs-4427	136	27	enhancer	enhancer	NOUN
gs-4427	136	28	preserves	preserve	VERB
gs-4427	136	29	bcl11a	bcl11a	X
gs-4427	136	30	function	function	NOUN
gs-4427	136	31	in	in	ADP
gs-4427	136	32	other	other	ADJ
gs-4427	136	33	cell	cell	NOUN
gs-4427	136	34	types	type	NOUN
gs-4427	136	35	while	while	SCONJ
gs-4427	136	36	specifically	specifically	ADV
gs-4427	136	37	reducing	reduce	VERB
gs-4427	136	38	expression	expression	NOUN
gs-4427	136	39	in	in	ADP
gs-4427	136	40	red	red	ADJ
gs-4427	136	41	blood	blood	NOUN
gs-4427	136	42	cell	cell	NOUN
gs-4427	136	43	precursors	precursor	NOUN
gs-4427	136	44	,	,	PUNCT
gs-4427	136	45	enabling	enable	VERB
gs-4427	136	46	fetal	fetal	ADJ
gs-4427	136	47	hemoglobin	hemoglobin	NOUN
gs-4427	136	48	reactivation	reactivation	NOUN
gs-4427	136	49	(	(	PUNCT
gs-4427	136	50	singh	singh	PROPN
gs-4427	136	51	et	et	PROPN
gs-4427	136	52	al	al	PROPN
gs-4427	136	53	.	.	PROPN
gs-4427	136	54	,	,	PUNCT
gs-4427	136	55	2024	2024	NUM
gs-4427	136	56	)	)	PUNCT
gs-4427	136	57	.	.	PUNCT
gs-4427	137	1	clinical	clinical	ADJ
gs-4427	137	2	trials	trial	NOUN
gs-4427	137	3	demonstrated	demonstrate	VERB
gs-4427	137	4	that	that	SCONJ
gs-4427	137	5	casgevy	casgevy	NOUN
gs-4427	137	6	-	-	PUNCT
gs-4427	137	7	treated	treat	VERB
gs-4427	137	8	patients	patient	NOUN
gs-4427	137	9	achieved	achieve	VERB
gs-4427	137	10	fetal	fetal	ADJ
gs-4427	137	11	hemoglobin	hemoglobin	NOUN
gs-4427	137	12	levels	level	NOUN
gs-4427	137	13	of	of	ADP
gs-4427	137	14	30	30	NUM
gs-4427	137	15	-	-	SYM
gs-4427	137	16	40	40	NUM
gs-4427	137	17	%	%	NOUN
gs-4427	137	18	of	of	ADP
gs-4427	137	19	total	total	ADJ
gs-4427	137	20	hemoglobin	hemoglobin	NOUN
gs-4427	137	21	,	,	PUNCT
gs-4427	137	22	with	with	ADP
gs-4427	137	23	complete	complete	ADJ
gs-4427	137	24	elimination	elimination	NOUN
gs-4427	137	25	of	of	ADP
gs-4427	137	26	vaso	vaso	NOUN
gs-4427	137	27	-	-	PUNCT
gs-4427	137	28	occlusive	occlusive	ADJ
gs-4427	137	29	crises	crisis	NOUN
gs-4427	137	30	in	in	ADP
gs-4427	137	31	the	the	DET
gs-4427	137	32	majority	majority	NOUN
gs-4427	137	33	of	of	ADP
gs-4427	137	34	sickle	sickle	NOUN
gs-4427	137	35	cell	cell	NOUN
gs-4427	137	36	disease	disease	NOUN
gs-4427	137	37	patients	patient	NOUN
gs-4427	137	38	throughout	throughout	ADP
gs-4427	137	39	follow	follow	VERB
gs-4427	137	40	-	-	PUNCT
gs-4427	137	41	up	up	ADP
gs-4427	137	42	periods	period	NOUN
gs-4427	137	43	extending	extend	VERB
gs-4427	137	44	beyond	beyond	ADP
gs-4427	137	45	two	two	NUM
gs-4427	137	46	years	year	NOUN
gs-4427	137	47	.	.	PUNCT
gs-4427	138	1	the	the	DET
gs-4427	138	2	therapy	therapy	NOUN
gs-4427	138	3	also	also	ADV
gs-4427	138	4	demonstrated	demonstrate	VERB
gs-4427	138	5	efficacy	efficacy	NOUN
gs-4427	138	6	in	in	ADP
gs-4427	138	7	transfusiondependent	transfusiondependent	ADJ
gs-4427	138	8	beta	beta	NOUN
gs-4427	138	9	thalassemia	thalassemia	NOUN
gs-4427	138	10	,	,	PUNCT
gs-4427	138	11	another	another	DET
gs-4427	138	12	hemoglobinopathy	hemoglobinopathy	NOUN
gs-4427	138	13	characterized	characterize	VERB
gs-4427	138	14	by	by	ADP
gs-4427	138	15	deficient	deficient	ADJ
gs-4427	138	16	betaglobin	betaglobin	NOUN
gs-4427	138	17	production	production	NOUN
gs-4427	138	18	,	,	PUNCT
gs-4427	138	19	with	with	ADP
gs-4427	138	20	most	most	ADV
gs-4427	138	21	treated	treat	VERB
gs-4427	138	22	patients	patient	NOUN
gs-4427	138	23	achieving	achieve	VERB
gs-4427	138	24	transfusion	transfusion	NOUN
gs-4427	138	25	independence	independence	NOUN
gs-4427	138	26	.	.	PUNCT
gs-4427	139	1	hemophilia	hemophilia	PROPN
gs-4427	139	2	a	a	PRON
gs-4427	139	3	and	and	CCONJ
gs-4427	139	4	b	b	NOUN
gs-4427	139	5	,	,	PUNCT
gs-4427	139	6	x	x	ADJ
gs-4427	139	7	-	-	VERB
gs-4427	139	8	linked	link	VERB
gs-4427	139	9	bleeding	bleeding	NOUN
gs-4427	139	10	disorders	disorder	NOUN
gs-4427	139	11	caused	cause	VERB
gs-4427	139	12	by	by	ADP
gs-4427	139	13	deficiency	deficiency	NOUN
gs-4427	139	14	of	of	ADP
gs-4427	139	15	coagulation	coagulation	NOUN
gs-4427	139	16	factors	factor	NOUN
gs-4427	139	17	viii	viii	ADJ
gs-4427	139	18	and	and	CCONJ
gs-4427	139	19	ix	ix	ADV
gs-4427	139	20	respectively	respectively	ADV
gs-4427	139	21	,	,	PUNCT
gs-4427	139	22	have	have	AUX
gs-4427	139	23	been	be	AUX
gs-4427	139	24	extensively	extensively	ADV
gs-4427	139	25	targeted	target	VERB
gs-4427	139	26	by	by	ADP
gs-4427	139	27	aav	aav	NOUN
gs-4427	139	28	gene	gene	NOUN
gs-4427	139	29	therapy	therapy	NOUN
gs-4427	139	30	approaches	approach	VERB
gs-4427	139	31	delivering	deliver	VERB
gs-4427	139	32	functional	functional	ADJ
gs-4427	139	33	factor	factor	NOUN
gs-4427	139	34	genes	gene	NOUN
gs-4427	139	35	to	to	ADP
gs-4427	139	36	hepatocytes	hepatocyte	NOUN
gs-4427	139	37	for	for	ADP
gs-4427	139	38	sustained	sustained	ADJ
gs-4427	139	39	protein	protein	NOUN
gs-4427	139	40	production	production	NOUN
gs-4427	139	41	.	.	PUNCT
gs-4427	140	1	the	the	DET
gs-4427	140	2	liver	liver	NOUN
gs-4427	140	3	represents	represent	VERB
gs-4427	140	4	an	an	DET
gs-4427	140	5	ideal	ideal	ADJ
gs-4427	140	6	target	target	NOUN
gs-4427	140	7	tissue	tissue	NOUN
gs-4427	140	8	for	for	ADP
gs-4427	140	9	hemophilia	hemophilia	NOUN
gs-4427	140	10	gene	gene	NOUN
gs-4427	140	11	therapy	therapy	NOUN
gs-4427	140	12	due	due	ADP
gs-4427	140	13	to	to	ADP
gs-4427	140	14	its	its	PRON
gs-4427	140	15	natural	natural	ADJ
gs-4427	140	16	role	role	NOUN
gs-4427	140	17	in	in	ADP
gs-4427	140	18	producing	produce	VERB
gs-4427	140	19	coagulation	coagulation	NOUN
gs-4427	140	20	factors	factor	NOUN
gs-4427	140	21	,	,	PUNCT
gs-4427	140	22	efficient	efficient	ADJ
gs-4427	140	23	transduction	transduction	NOUN
gs-4427	140	24	by	by	ADP
gs-4427	140	25	aav	aav	NOUN
gs-4427	140	26	vectors	vector	NOUN
gs-4427	140	27	,	,	PUNCT
gs-4427	140	28	georgian	georgian	NOUN
gs-4427	140	29	scientists/	scientists/	NUM
gs-4427	140	30	.	.	PUNCT
gs-4427	141	1	7	7	NUM
gs-4427	141	2	n	n	DET
gs-4427	141	3	4	4	NUM
gs-4427	141	4	,	,	PUNCT
gs-4427	141	5	2025	2025	NUM
gs-4427	141	6	639	639	NUM
gs-4427	141	7	relatively	relatively	ADV
gs-4427	141	8	immunologically	immunologically	ADV
gs-4427	141	9	privileged	privileged	ADJ
gs-4427	141	10	environment	environment	NOUN
gs-4427	141	11	,	,	PUNCT
gs-4427	141	12	and	and	CCONJ
gs-4427	141	13	large	large	ADJ
gs-4427	141	14	reserve	reserve	NOUN
gs-4427	141	15	capacity	capacity	NOUN
gs-4427	141	16	allowing	allow	VERB
gs-4427	141	17	therapeutic	therapeutic	ADJ
gs-4427	141	18	benefit	benefit	NOUN
gs-4427	141	19	from	from	ADP
gs-4427	141	20	transduction	transduction	NOUN
gs-4427	141	21	of	of	ADP
gs-4427	141	22	only	only	ADV
gs-4427	141	23	a	a	DET
gs-4427	141	24	fraction	fraction	NOUN
gs-4427	141	25	of	of	ADP
gs-4427	141	26	hepatocytes	hepatocyte	NOUN
gs-4427	141	27	.	.	PUNCT
gs-4427	142	1	multiple	multiple	ADJ
gs-4427	142	2	hemophilia	hemophilia	PROPN
gs-4427	142	3	b	b	PROPN
gs-4427	142	4	gene	gene	NOUN
gs-4427	142	5	therapy	therapy	NOUN
gs-4427	142	6	products	product	NOUN
gs-4427	142	7	have	have	AUX
gs-4427	142	8	demonstrated	demonstrate	VERB
gs-4427	142	9	that	that	SCONJ
gs-4427	142	10	single	single	ADJ
gs-4427	142	11	intravenous	intravenous	PROPN
gs-4427	142	12	aav	aav	PROPN
gs-4427	142	13	vector	vector	NOUN
gs-4427	142	14	administration	administration	NOUN
gs-4427	142	15	can	can	AUX
gs-4427	142	16	achieve	achieve	VERB
gs-4427	142	17	sustained	sustained	ADJ
gs-4427	142	18	factor	factor	NOUN
gs-4427	142	19	ix	ix	ADP
gs-4427	142	20	expression	expression	NOUN
gs-4427	142	21	at	at	ADP
gs-4427	142	22	levels	level	NOUN
gs-4427	142	23	converting	convert	VERB
gs-4427	142	24	severe	severe	ADJ
gs-4427	142	25	hemophilia	hemophilia	NOUN
gs-4427	142	26	(	(	PUNCT
gs-4427	142	27	factor	factor	NOUN
gs-4427	142	28	levels	level	NOUN
gs-4427	142	29	less	less	ADJ
gs-4427	142	30	than	than	ADP
gs-4427	142	31	1	1	NUM
gs-4427	142	32	%	%	NOUN
gs-4427	142	33	of	of	ADP
gs-4427	142	34	normal	normal	ADJ
gs-4427	142	35	)	)	PUNCT
gs-4427	142	36	to	to	ADP
gs-4427	142	37	mild	mild	ADJ
gs-4427	142	38	phenotype	phenotype	NOUN
gs-4427	142	39	(	(	PUNCT
gs-4427	142	40	factor	factor	NOUN
gs-4427	142	41	levels	level	NOUN
gs-4427	142	42	5	5	NUM
gs-4427	142	43	-	-	SYM
gs-4427	142	44	40	40	NUM
gs-4427	142	45	%	%	NOUN
gs-4427	142	46	of	of	ADP
gs-4427	142	47	normal	normal	ADJ
gs-4427	142	48	)	)	PUNCT
gs-4427	142	49	,	,	PUNCT
gs-4427	142	50	dramatically	dramatically	ADV
gs-4427	142	51	reducing	reduce	VERB
gs-4427	142	52	bleeding	bleeding	NOUN
gs-4427	142	53	episodes	episode	NOUN
gs-4427	142	54	and	and	CCONJ
gs-4427	142	55	eliminating	eliminate	VERB
gs-4427	142	56	or	or	CCONJ
gs-4427	142	57	substantially	substantially	ADV
gs-4427	142	58	reducing	reduce	VERB
gs-4427	142	59	the	the	DET
gs-4427	142	60	need	need	NOUN
gs-4427	142	61	for	for	ADP
gs-4427	142	62	prophylactic	prophylactic	ADJ
gs-4427	142	63	factor	factor	NOUN
gs-4427	142	64	replacement	replacement	NOUN
gs-4427	142	65	infusions	infusion	NOUN
gs-4427	142	66	.	.	PUNCT
gs-4427	143	1	beqvez	beqvez	ADJ
gs-4427	143	2	,	,	PUNCT
gs-4427	143	3	approved	approve	VERB
gs-4427	143	4	in	in	ADP
gs-4427	143	5	2024	2024	NUM
gs-4427	143	6	,	,	PUNCT
gs-4427	143	7	demonstrated	demonstrate	VERB
gs-4427	143	8	mean	mean	ADJ
gs-4427	143	9	factor	factor	NOUN
gs-4427	143	10	ix	ix	ADP
gs-4427	143	11	activity	activity	NOUN
gs-4427	143	12	of	of	ADP
gs-4427	143	13	approximately	approximately	ADV
gs-4427	143	14	36	36	NUM
gs-4427	143	15	%	%	NOUN
gs-4427	143	16	of	of	ADP
gs-4427	143	17	normal	normal	ADJ
gs-4427	143	18	at	at	ADP
gs-4427	143	19	one	one	NUM
gs-4427	143	20	-	-	PUNCT
gs-4427	143	21	year	year	NOUN
gs-4427	143	22	posttreatment	posttreatment	NOUN
gs-4427	143	23	,	,	PUNCT
gs-4427	143	24	with	with	ADP
gs-4427	143	25	sustained	sustained	ADJ
gs-4427	143	26	expression	expression	NOUN
gs-4427	143	27	through	through	ADP
gs-4427	143	28	multi	multi	ADJ
gs-4427	143	29	-	-	ADJ
gs-4427	143	30	year	year	ADJ
gs-4427	143	31	follow	follow	NOUN
gs-4427	143	32	-	-	PUNCT
gs-4427	143	33	up	up	NOUN
gs-4427	143	34	in	in	ADP
gs-4427	143	35	most	most	ADJ
gs-4427	143	36	patients	patient	NOUN
gs-4427	143	37	and	and	CCONJ
gs-4427	143	38	elimination	elimination	NOUN
gs-4427	143	39	of	of	ADP
gs-4427	143	40	bleeding	bleed	VERB
gs-4427	143	41	episodes	episode	NOUN
gs-4427	143	42	in	in	ADP
gs-4427	143	43	the	the	DET
gs-4427	143	44	majority	majority	NOUN
gs-4427	143	45	.	.	PUNCT
gs-4427	144	1	challenges	challenge	NOUN
gs-4427	144	2	and	and	CCONJ
gs-4427	144	3	barriers	barrier	NOUN
gs-4427	144	4	to	to	ADP
gs-4427	144	5	broader	broad	ADJ
gs-4427	144	6	implementation	implementation	NOUN
gs-4427	144	7	despite	despite	SCONJ
gs-4427	144	8	remarkable	remarkable	ADJ
gs-4427	144	9	scientific	scientific	ADJ
gs-4427	144	10	and	and	CCONJ
gs-4427	144	11	clinical	clinical	ADJ
gs-4427	144	12	progress	progress	NOUN
gs-4427	144	13	,	,	PUNCT
gs-4427	144	14	gene	gene	NOUN
gs-4427	144	15	therapy	therapy	NOUN
gs-4427	144	16	faces	face	VERB
gs-4427	144	17	substantial	substantial	ADJ
gs-4427	144	18	challenges	challenge	NOUN
gs-4427	144	19	that	that	PRON
gs-4427	144	20	limit	limit	VERB
gs-4427	144	21	broader	broad	ADJ
gs-4427	144	22	patient	patient	ADJ
gs-4427	144	23	access	access	NOUN
gs-4427	144	24	and	and	CCONJ
gs-4427	144	25	therapeutic	therapeutic	ADJ
gs-4427	144	26	application	application	NOUN
gs-4427	144	27	across	across	ADP
gs-4427	144	28	diverse	diverse	ADJ
gs-4427	144	29	diseases	disease	NOUN
gs-4427	144	30	.	.	PUNCT
gs-4427	145	1	economic	economic	ADJ
gs-4427	145	2	factors	factor	NOUN
gs-4427	145	3	represent	represent	VERB
gs-4427	145	4	perhaps	perhaps	ADV
gs-4427	145	5	the	the	DET
gs-4427	145	6	most	most	ADV
gs-4427	145	7	significant	significant	ADJ
gs-4427	145	8	barrier	barrier	NOUN
gs-4427	145	9	,	,	PUNCT
gs-4427	145	10	with	with	ADP
gs-4427	145	11	approved	approve	VERB
gs-4427	145	12	gene	gene	NOUN
gs-4427	145	13	therapies	therapy	NOUN
gs-4427	145	14	priced	price	VERB
gs-4427	145	15	between	between	ADP
gs-4427	145	16	$	$	SYM
gs-4427	145	17	400,000	400,000	NUM
gs-4427	145	18	and	and	CCONJ
gs-4427	145	19	$	$	SYM
gs-4427	145	20	4.25	4.25	NUM
gs-4427	145	21	million	million	NUM
gs-4427	145	22	per	per	ADP
gs-4427	145	23	treatment	treatment	NOUN
gs-4427	145	24	,	,	PUNCT
gs-4427	145	25	reflecting	reflect	VERB
gs-4427	145	26	high	high	ADJ
gs-4427	145	27	development	development	NOUN
gs-4427	145	28	costs	cost	NOUN
gs-4427	145	29	,	,	PUNCT
gs-4427	145	30	complex	complex	ADJ
gs-4427	145	31	manufacturing	manufacturing	NOUN
gs-4427	145	32	requirements	requirement	NOUN
gs-4427	145	33	,	,	PUNCT
gs-4427	145	34	small	small	ADJ
gs-4427	145	35	patient	patient	ADJ
gs-4427	145	36	populations	population	NOUN
gs-4427	145	37	for	for	ADP
gs-4427	145	38	rare	rare	ADJ
gs-4427	145	39	disease	disease	NOUN
gs-4427	145	40	indications	indication	NOUN
gs-4427	145	41	,	,	PUNCT
gs-4427	145	42	and	and	CCONJ
gs-4427	145	43	pharmaceutical	pharmaceutical	NOUN
gs-4427	145	44	industry	industry	NOUN
gs-4427	145	45	pricing	pricing	NOUN
gs-4427	145	46	strategies	strategy	NOUN
gs-4427	145	47	.	.	PUNCT
gs-4427	146	1	while	while	SCONJ
gs-4427	146	2	health	health	NOUN
gs-4427	146	3	economic	economic	ADJ
gs-4427	146	4	analyses	analysis	NOUN
gs-4427	146	5	often	often	ADV
gs-4427	146	6	conclude	conclude	VERB
gs-4427	146	7	that	that	SCONJ
gs-4427	146	8	single	single	ADJ
gs-4427	146	9	-	-	PUNCT
gs-4427	146	10	administration	administration	NOUN
gs-4427	146	11	curative	curative	ADJ
gs-4427	146	12	therapies	therapy	NOUN
gs-4427	146	13	represent	represent	VERB
gs-4427	146	14	good	good	ADJ
gs-4427	146	15	value	value	NOUN
gs-4427	146	16	compared	compare	VERB
gs-4427	146	17	to	to	ADP
gs-4427	146	18	lifelong	lifelong	ADJ
gs-4427	146	19	conventional	conventional	ADJ
gs-4427	146	20	treatments	treatment	NOUN
gs-4427	146	21	when	when	SCONJ
gs-4427	146	22	assessed	assess	VERB
gs-4427	146	23	over	over	ADP
gs-4427	146	24	patient	patient	NOUN
gs-4427	146	25	lifetimes	lifetime	NOUN
gs-4427	146	26	,	,	PUNCT
gs-4427	146	27	the	the	DET
gs-4427	146	28	concentrated	concentrate	VERB
gs-4427	146	29	upfront	upfront	ADJ
gs-4427	146	30	costs	cost	NOUN
gs-4427	146	31	create	create	VERB
gs-4427	146	32	significant	significant	ADJ
gs-4427	146	33	budget	budget	NOUN
gs-4427	146	34	impact	impact	NOUN
gs-4427	146	35	challenges	challenge	NOUN
gs-4427	146	36	for	for	ADP
gs-4427	146	37	healthcare	healthcare	NOUN
gs-4427	146	38	payers	payer	NOUN
gs-4427	146	39	and	and	CCONJ
gs-4427	146	40	threaten	threaten	VERB
gs-4427	146	41	to	to	PART
gs-4427	146	42	overwhelm	overwhelm	VERB
gs-4427	146	43	healthcare	healthcare	NOUN
gs-4427	146	44	system	system	NOUN
gs-4427	146	45	resources	resource	NOUN
gs-4427	146	46	if	if	SCONJ
gs-4427	146	47	gene	gene	NOUN
gs-4427	146	48	therapy	therapy	NOUN
gs-4427	146	49	utilization	utilization	NOUN
gs-4427	146	50	scales	scale	VERB
gs-4427	146	51	substantially	substantially	ADV
gs-4427	146	52	.	.	PUNCT
gs-4427	147	1	the	the	DET
gs-4427	147	2	tension	tension	NOUN
gs-4427	147	3	between	between	ADP
gs-4427	147	4	recognizing	recognize	VERB
gs-4427	147	5	gene	gene	NOUN
gs-4427	147	6	therapy	therapy	NOUN
gs-4427	147	7	's	's	PART
gs-4427	147	8	transformative	transformative	ADJ
gs-4427	147	9	potential	potential	NOUN
gs-4427	147	10	and	and	CCONJ
gs-4427	147	11	constraining	constrain	VERB
gs-4427	147	12	healthcare	healthcare	NOUN
gs-4427	147	13	expenditure	expenditure	NOUN
gs-4427	147	14	growth	growth	NOUN
gs-4427	147	15	has	have	AUX
gs-4427	147	16	generated	generate	VERB
gs-4427	147	17	intense	intense	ADJ
gs-4427	147	18	debate	debate	NOUN
gs-4427	147	19	regarding	regard	VERB
gs-4427	147	20	appropriate	appropriate	ADJ
gs-4427	147	21	pricing	pricing	NOUN
gs-4427	147	22	frameworks	framework	NOUN
gs-4427	147	23	,	,	PUNCT
gs-4427	147	24	reimbursement	reimbursement	NOUN
gs-4427	147	25	models	model	NOUN
gs-4427	147	26	,	,	PUNCT
gs-4427	147	27	and	and	CCONJ
gs-4427	147	28	societal	societal	ADJ
gs-4427	147	29	willingness	willingness	NOUN
gs-4427	147	30	to	to	PART
gs-4427	147	31	pay	pay	VERB
gs-4427	147	32	for	for	ADP
gs-4427	147	33	potentially	potentially	ADV
gs-4427	147	34	curative	curative	ADJ
gs-4427	147	35	treatments	treatment	NOUN
gs-4427	147	36	.	.	PUNCT
gs-4427	148	1	manufacturing	manufacture	VERB
gs-4427	148	2	complexities	complexity	NOUN
gs-4427	148	3	and	and	CCONJ
gs-4427	148	4	capacity	capacity	NOUN
gs-4427	148	5	limitations	limitation	NOUN
gs-4427	148	6	represent	represent	VERB
gs-4427	148	7	additional	additional	ADJ
gs-4427	148	8	critical	critical	ADJ
gs-4427	148	9	barriers	barrier	NOUN
gs-4427	148	10	,	,	PUNCT
gs-4427	148	11	particularly	particularly	ADV
gs-4427	148	12	for	for	ADP
gs-4427	148	13	autologous	autologous	ADJ
gs-4427	148	14	cell	cell	NOUN
gs-4427	148	15	therapies	therapy	NOUN
gs-4427	148	16	requiring	require	VERB
gs-4427	148	17	individualized	individualized	ADJ
gs-4427	148	18	production	production	NOUN
gs-4427	148	19	for	for	ADP
gs-4427	148	20	each	each	DET
gs-4427	148	21	patient	patient	NOUN
gs-4427	148	22	.	.	PUNCT
gs-4427	149	1	car	car	NOUN
gs-4427	149	2	-	-	PUNCT
gs-4427	149	3	t	t	NOUN
gs-4427	149	4	cell	cell	NOUN
gs-4427	149	5	manufacturing	manufacturing	NOUN
gs-4427	149	6	involves	involve	VERB
gs-4427	149	7	multiple	multiple	ADJ
gs-4427	149	8	technically	technically	ADV
gs-4427	149	9	demanding	demanding	ADJ
gs-4427	149	10	steps	step	NOUN
gs-4427	149	11	including	include	VERB
gs-4427	149	12	patient	patient	ADJ
gs-4427	149	13	leukapheresis	leukapheresis	NOUN
gs-4427	149	14	,	,	PUNCT
gs-4427	149	15	cell	cell	NOUN
gs-4427	149	16	activation	activation	NOUN
gs-4427	149	17	and	and	CCONJ
gs-4427	149	18	transduction	transduction	NOUN
gs-4427	149	19	with	with	ADP
gs-4427	149	20	viral	viral	ADJ
gs-4427	149	21	vectors	vector	NOUN
gs-4427	149	22	,	,	PUNCT
gs-4427	149	23	expansion	expansion	NOUN
gs-4427	149	24	culture	culture	NOUN
gs-4427	149	25	under	under	ADP
gs-4427	149	26	tightly	tightly	ADV
gs-4427	149	27	controlled	control	VERB
gs-4427	149	28	conditions	condition	NOUN
gs-4427	149	29	,	,	PUNCT
gs-4427	149	30	extensive	extensive	ADJ
gs-4427	149	31	quality	quality	NOUN
gs-4427	149	32	control	control	NOUN
gs-4427	149	33	testing	testing	NOUN
gs-4427	149	34	,	,	PUNCT
gs-4427	149	35	formulation	formulation	NOUN
gs-4427	149	36	,	,	PUNCT
gs-4427	149	37	cryopreservation	cryopreservation	NOUN
gs-4427	149	38	,	,	PUNCT
gs-4427	149	39	and	and	CCONJ
gs-4427	149	40	distribution	distribution	NOUN
gs-4427	149	41	to	to	ADP
gs-4427	149	42	treatment	treatment	NOUN
gs-4427	149	43	centers	center	NOUN
gs-4427	149	44	,	,	PUNCT
gs-4427	149	45	requiring	require	VERB
gs-4427	149	46	approximately	approximately	ADV
gs-4427	149	47	2	2	NUM
gs-4427	149	48	-	-	SYM
gs-4427	149	49	4	4	NUM
gs-4427	149	50	weeks	week	NOUN
gs-4427	149	51	and	and	CCONJ
gs-4427	149	52	sophisticated	sophisticated	ADJ
gs-4427	149	53	facilities	facility	NOUN
gs-4427	149	54	meeting	meet	VERB
gs-4427	149	55	good	good	ADJ
gs-4427	149	56	manufacturing	manufacturing	NOUN
gs-4427	149	57	practice	practice	NOUN
gs-4427	149	58	standards	standard	NOUN
gs-4427	149	59	.	.	PUNCT
gs-4427	150	1	manufacturing	manufacturing	NOUN
gs-4427	150	2	failures	failure	NOUN
gs-4427	150	3	occur	occur	VERB
gs-4427	150	4	in	in	ADP
gs-4427	150	5	2	2	NUM
gs-4427	150	6	-	-	SYM
gs-4427	150	7	10	10	NUM
gs-4427	150	8	%	%	NOUN
gs-4427	150	9	of	of	ADP
gs-4427	150	10	cases	case	NOUN
gs-4427	150	11	depending	depend	VERB
gs-4427	150	12	on	on	ADP
gs-4427	150	13	product	product	NOUN
gs-4427	150	14	and	and	CCONJ
gs-4427	150	15	patient	patient	NOUN
gs-4427	150	16	characteristics	characteristic	NOUN
gs-4427	150	17	,	,	PUNCT
gs-4427	150	18	necessitating	necessitate	VERB
gs-4427	150	19	restart	restart	NOUN
gs-4427	150	20	of	of	ADP
gs-4427	150	21	the	the	DET
gs-4427	150	22	process	process	NOUN
gs-4427	150	23	and	and	CCONJ
gs-4427	150	24	delaying	delay	VERB
gs-4427	150	25	treatment	treatment	NOUN
gs-4427	150	26	for	for	ADP
gs-4427	150	27	rapidly	rapidly	ADV
gs-4427	150	28	progressing	progress	VERB
gs-4427	150	29	patients	patient	NOUN
gs-4427	150	30	.	.	PUNCT
gs-4427	151	1	the	the	DET
gs-4427	151	2	current	current	ADJ
gs-4427	151	3	centralized	centralized	ADJ
gs-4427	151	4	manufacturing	manufacturing	NOUN
gs-4427	151	5	model	model	NOUN
gs-4427	151	6	,	,	PUNCT
gs-4427	151	7	with	with	ADP
gs-4427	151	8	most	most	ADJ
gs-4427	151	9	production	production	NOUN
gs-4427	151	10	occurring	occur	VERB
gs-4427	151	11	at	at	ADP
gs-4427	151	12	a	a	DET
gs-4427	151	13	limited	limited	ADJ
gs-4427	151	14	number	number	NOUN
gs-4427	151	15	of	of	ADP
gs-4427	151	16	specialized	specialized	ADJ
gs-4427	151	17	facilities	facility	NOUN
gs-4427	151	18	,	,	PUNCT
gs-4427	151	19	creates	create	VERB
gs-4427	151	20	logistical	logistical	ADJ
gs-4427	151	21	challenges	challenge	NOUN
gs-4427	151	22	and	and	CCONJ
gs-4427	151	23	limits	limit	VERB
gs-4427	151	24	treatment	treatment	NOUN
gs-4427	151	25	capacity	capacity	NOUN
gs-4427	151	26	.	.	PUNCT
gs-4427	152	1	alternative	alternative	ADJ
gs-4427	152	2	approaches	approach	NOUN
gs-4427	152	3	under	under	ADP
gs-4427	152	4	development	development	NOUN
gs-4427	152	5	include	include	VERB
gs-4427	152	6	point	point	NOUN
gs-4427	152	7	-	-	PUNCT
gs-4427	152	8	of	of	ADP
gs-4427	152	9	-	-	PUNCT
gs-4427	152	10	care	care	NOUN
gs-4427	152	11	manufacturing	manufacturing	NOUN
gs-4427	152	12	enabling	enable	VERB
gs-4427	152	13	production	production	NOUN
gs-4427	152	14	at	at	ADP
gs-4427	152	15	treatment	treatment	NOUN
gs-4427	152	16	centers	center	NOUN
gs-4427	152	17	,	,	PUNCT
gs-4427	152	18	automation	automation	NOUN
gs-4427	152	19	technologies	technology	NOUN
gs-4427	152	20	reducing	reduce	VERB
gs-4427	152	21	georgian	georgian	NOUN
gs-4427	152	22	scientists/	scientists/	NUM
gs-4427	152	23	.	.	PUNCT
gs-4427	153	1	7	7	NUM
gs-4427	153	2	n	n	DET
gs-4427	153	3	4	4	NUM
gs-4427	153	4	,	,	PUNCT
gs-4427	153	5	2025	2025	NUM
gs-4427	153	6	640	640	NUM
gs-4427	153	7	hands	hand	NOUN
gs-4427	153	8	-	-	PUNCT
gs-4427	153	9	on	on	ADP
gs-4427	153	10	manipulation	manipulation	NOUN
gs-4427	153	11	and	and	CCONJ
gs-4427	153	12	potential	potential	NOUN
gs-4427	153	13	for	for	ADP
gs-4427	153	14	contamination	contamination	NOUN
gs-4427	153	15	,	,	PUNCT
gs-4427	153	16	and	and	CCONJ
gs-4427	153	17	off	off	ADP
gs-4427	153	18	-	-	PUNCT
gs-4427	153	19	the	the	DET
gs-4427	153	20	-	-	PUNCT
gs-4427	153	21	shelf	shelf	NOUN
gs-4427	153	22	allogeneic	allogeneic	ADJ
gs-4427	153	23	products	product	NOUN
gs-4427	153	24	eliminating	eliminate	VERB
gs-4427	153	25	individualized	individualized	ADJ
gs-4427	153	26	manufacturing	manufacturing	NOUN
gs-4427	153	27	requirements	requirement	NOUN
gs-4427	153	28	but	but	CCONJ
gs-4427	153	29	facing	face	VERB
gs-4427	153	30	their	their	PRON
gs-4427	153	31	own	own	ADJ
gs-4427	153	32	challenges	challenge	NOUN
gs-4427	153	33	related	relate	VERB
gs-4427	153	34	to	to	ADP
gs-4427	153	35	immune	immune	ADJ
gs-4427	153	36	rejection	rejection	NOUN
gs-4427	153	37	and	and	CCONJ
gs-4427	153	38	limited	limited	ADJ
gs-4427	153	39	persistence	persistence	NOUN
gs-4427	153	40	.	.	PUNCT
gs-4427	154	1	immunogenicity	immunogenicity	NOUN
gs-4427	154	2	issues	issue	NOUN
gs-4427	154	3	affecting	affect	VERB
gs-4427	154	4	both	both	DET
gs-4427	154	5	vector	vector	NOUN
gs-4427	154	6	components	component	NOUN
gs-4427	154	7	and	and	CCONJ
gs-4427	154	8	transgene	transgene	ADJ
gs-4427	154	9	products	product	NOUN
gs-4427	154	10	can	can	AUX
gs-4427	154	11	limit	limit	VERB
gs-4427	154	12	therapeutic	therapeutic	ADJ
gs-4427	154	13	efficacy	efficacy	NOUN
gs-4427	154	14	and	and	CCONJ
gs-4427	154	15	create	create	VERB
gs-4427	154	16	safety	safety	NOUN
gs-4427	154	17	concerns	concern	NOUN
gs-4427	154	18	.	.	PUNCT
gs-4427	155	1	pre	pre	ADJ
gs-4427	155	2	-	-	ADJ
gs-4427	155	3	existing	exist	VERB
gs-4427	155	4	neutralizing	neutralizing	ADJ
gs-4427	155	5	antibodies	antibody	NOUN
gs-4427	155	6	to	to	ADP
gs-4427	155	7	aav	aav	PROPN
gs-4427	155	8	capsids	capsid	NOUN
gs-4427	155	9	,	,	PUNCT
gs-4427	155	10	present	present	ADJ
gs-4427	155	11	in	in	ADP
gs-4427	155	12	30	30	NUM
gs-4427	155	13	-	-	SYM
gs-4427	155	14	50	50	NUM
gs-4427	155	15	%	%	NOUN
gs-4427	155	16	of	of	ADP
gs-4427	155	17	the	the	DET
gs-4427	155	18	population	population	NOUN
gs-4427	155	19	depending	depend	VERB
gs-4427	155	20	on	on	ADP
gs-4427	155	21	serotype	serotype	NOUN
gs-4427	155	22	,	,	PUNCT
gs-4427	155	23	preclude	preclude	VERB
gs-4427	155	24	treatment	treatment	NOUN
gs-4427	155	25	of	of	ADP
gs-4427	155	26	substantial	substantial	ADJ
gs-4427	155	27	patient	patient	ADJ
gs-4427	155	28	fractions	fraction	NOUN
gs-4427	155	29	.	.	PUNCT
gs-4427	156	1	even	even	ADV
gs-4427	156	2	in	in	ADP
gs-4427	156	3	antibody	antibody	NOUN
gs-4427	156	4	-	-	PUNCT
gs-4427	156	5	negative	negative	ADJ
gs-4427	156	6	individuals	individual	NOUN
gs-4427	156	7	,	,	PUNCT
gs-4427	156	8	vector	vector	NOUN
gs-4427	156	9	administration	administration	NOUN
gs-4427	156	10	triggers	trigger	VERB
gs-4427	156	11	adaptive	adaptive	ADJ
gs-4427	156	12	immune	immune	ADJ
gs-4427	156	13	responses	response	NOUN
gs-4427	156	14	generating	generate	VERB
gs-4427	156	15	high	high	ADJ
gs-4427	156	16	-	-	PUNCT
gs-4427	156	17	titer	titer	NOUN
gs-4427	156	18	neutralizing	neutralize	VERB
gs-4427	156	19	antibodies	antibody	NOUN
gs-4427	156	20	that	that	PRON
gs-4427	156	21	prevent	prevent	VERB
gs-4427	156	22	re	re	VERB
gs-4427	156	23	-	-	VERB
gs-4427	156	24	dosing	dose	VERB
gs-4427	156	25	with	with	ADP
gs-4427	156	26	the	the	DET
gs-4427	156	27	same	same	ADJ
gs-4427	156	28	serotype	serotype	NOUN
gs-4427	156	29	.	.	PUNCT
gs-4427	157	1	cellular	cellular	ADJ
gs-4427	157	2	immune	immune	ADJ
gs-4427	157	3	responses	response	NOUN
gs-4427	157	4	directed	direct	VERB
gs-4427	157	5	against	against	ADP
gs-4427	157	6	aav	aav	NOUN
gs-4427	157	7	capsid	capsid	NOUN
gs-4427	157	8	peptides	peptide	NOUN
gs-4427	157	9	presented	present	VERB
gs-4427	157	10	on	on	ADP
gs-4427	157	11	transduced	transduced	ADJ
gs-4427	157	12	cells	cell	NOUN
gs-4427	157	13	can	can	AUX
gs-4427	157	14	mediate	mediate	VERB
gs-4427	157	15	clearance	clearance	NOUN
gs-4427	157	16	of	of	ADP
gs-4427	157	17	transduced	transduced	ADJ
gs-4427	157	18	cells	cell	NOUN
gs-4427	157	19	and	and	CCONJ
gs-4427	157	20	loss	loss	NOUN
gs-4427	157	21	of	of	ADP
gs-4427	157	22	transgene	transgene	ADJ
gs-4427	157	23	expression	expression	NOUN
gs-4427	157	24	,	,	PUNCT
gs-4427	157	25	as	as	SCONJ
gs-4427	157	26	observed	observe	VERB
gs-4427	157	27	in	in	ADP
gs-4427	157	28	some	some	DET
gs-4427	157	29	hemophilia	hemophilia	NOUN
gs-4427	157	30	gene	gene	NOUN
gs-4427	157	31	therapy	therapy	NOUN
gs-4427	157	32	trials	trial	NOUN
gs-4427	157	33	where	where	SCONJ
gs-4427	157	34	factor	factor	NOUN
gs-4427	157	35	levels	level	NOUN
gs-4427	157	36	declined	decline	VERB
gs-4427	157	37	months	month	NOUN
gs-4427	157	38	after	after	SCONJ
gs-4427	157	39	initial	initial	ADJ
gs-4427	157	40	therapeutic	therapeutic	ADJ
gs-4427	157	41	levels	level	NOUN
gs-4427	157	42	were	be	AUX
gs-4427	157	43	achieved	achieve	VERB
gs-4427	157	44	.	.	PUNCT
gs-4427	158	1	immunosuppression	immunosuppression	NOUN
gs-4427	158	2	protocols	protocol	NOUN
gs-4427	158	3	initiated	initiate	VERB
gs-4427	158	4	at	at	ADP
gs-4427	158	5	the	the	DET
gs-4427	158	6	time	time	NOUN
gs-4427	158	7	of	of	ADP
gs-4427	158	8	vector	vector	NOUN
gs-4427	158	9	administration	administration	NOUN
gs-4427	158	10	may	may	AUX
gs-4427	158	11	mitigate	mitigate	VERB
gs-4427	158	12	these	these	DET
gs-4427	158	13	responses	response	NOUN
gs-4427	158	14	but	but	CCONJ
gs-4427	158	15	add	add	VERB
gs-4427	158	16	complexity	complexity	NOUN
gs-4427	158	17	and	and	CCONJ
gs-4427	158	18	potential	potential	ADJ
gs-4427	158	19	toxicity	toxicity	NOUN
gs-4427	158	20	.	.	PUNCT
gs-4427	159	1	immune	immune	ADJ
gs-4427	159	2	responses	response	NOUN
gs-4427	159	3	against	against	ADP
gs-4427	159	4	transgene	transgene	ADJ
gs-4427	159	5	products	product	NOUN
gs-4427	159	6	represent	represent	VERB
gs-4427	159	7	another	another	DET
gs-4427	159	8	concern	concern	NOUN
gs-4427	159	9	,	,	PUNCT
gs-4427	159	10	particularly	particularly	ADV
gs-4427	159	11	in	in	ADP
gs-4427	159	12	patients	patient	NOUN
gs-4427	159	13	with	with	ADP
gs-4427	159	14	severe	severe	ADJ
gs-4427	159	15	mutations	mutation	NOUN
gs-4427	159	16	resulting	result	VERB
gs-4427	159	17	in	in	ADP
gs-4427	159	18	complete	complete	ADJ
gs-4427	159	19	absence	absence	NOUN
gs-4427	159	20	of	of	ADP
gs-4427	159	21	the	the	DET
gs-4427	159	22	native	native	ADJ
gs-4427	159	23	protein	protein	NOUN
gs-4427	159	24	,	,	PUNCT
gs-4427	159	25	who	who	PRON
gs-4427	159	26	may	may	AUX
gs-4427	159	27	recognize	recognize	VERB
gs-4427	159	28	the	the	DET
gs-4427	159	29	gene	gene	NOUN
gs-4427	159	30	therapy	therapy	NOUN
gs-4427	159	31	-	-	PUNCT
gs-4427	159	32	produced	produce	VERB
gs-4427	159	33	protein	protein	NOUN
gs-4427	159	34	as	as	ADP
gs-4427	159	35	foreign	foreign	ADJ
gs-4427	159	36	and	and	CCONJ
gs-4427	159	37	mount	mount	NOUN
gs-4427	159	38	antibody	antibody	NOUN
gs-4427	159	39	responses	response	NOUN
gs-4427	159	40	neutralizing	neutralize	VERB
gs-4427	159	41	therapeutic	therapeutic	ADJ
gs-4427	159	42	benefit	benefit	NOUN
gs-4427	159	43	.	.	PUNCT
gs-4427	160	1	long	long	ADJ
gs-4427	160	2	-	-	PUNCT
gs-4427	160	3	term	term	NOUN
gs-4427	160	4	safety	safety	NOUN
gs-4427	160	5	surveillance	surveillance	NOUN
gs-4427	160	6	requirements	requirement	NOUN
gs-4427	160	7	and	and	CCONJ
gs-4427	160	8	ongoing	ongoing	ADJ
gs-4427	160	9	questions	question	NOUN
gs-4427	160	10	about	about	ADP
gs-4427	160	11	potential	potential	ADJ
gs-4427	160	12	lateemerging	lateemerge	VERB
gs-4427	160	13	risks	risk	NOUN
gs-4427	160	14	necessitate	necessitate	ADJ
gs-4427	160	15	extended	extended	ADJ
gs-4427	160	16	follow	follow	NOUN
gs-4427	160	17	-	-	PUNCT
gs-4427	160	18	up	up	NOUN
gs-4427	160	19	extending	extend	VERB
gs-4427	160	20	15	15	NUM
gs-4427	160	21	years	year	NOUN
gs-4427	160	22	post	post	ADJ
gs-4427	160	23	-	-	NOUN
gs-4427	160	24	treatment	treatment	NOUN
gs-4427	160	25	for	for	ADP
gs-4427	160	26	gene	gene	NOUN
gs-4427	160	27	therapies	therapy	NOUN
gs-4427	160	28	involving	involve	VERB
gs-4427	160	29	genomic	genomic	ADJ
gs-4427	160	30	modification	modification	NOUN
gs-4427	160	31	,	,	PUNCT
gs-4427	160	32	creating	create	VERB
gs-4427	160	33	substantial	substantial	ADJ
gs-4427	160	34	logistical	logistical	ADJ
gs-4427	160	35	and	and	CCONJ
gs-4427	160	36	financial	financial	ADJ
gs-4427	160	37	burdens	burden	NOUN
gs-4427	160	38	for	for	ADP
gs-4427	160	39	developers	developer	NOUN
gs-4427	160	40	and	and	CCONJ
gs-4427	160	41	patients	patient	NOUN
gs-4427	160	42	.	.	PUNCT
gs-4427	161	1	while	while	SCONJ
gs-4427	161	2	no	no	DET
gs-4427	161	3	late	late	ADV
gs-4427	161	4	-	-	PUNCT
gs-4427	161	5	emerging	emerge	VERB
gs-4427	161	6	safety	safety	NOUN
gs-4427	161	7	signals	signal	NOUN
gs-4427	161	8	have	have	AUX
gs-4427	161	9	appeared	appear	VERB
gs-4427	161	10	in	in	ADP
gs-4427	161	11	most	most	ADJ
gs-4427	161	12	gene	gene	NOUN
gs-4427	161	13	therapy	therapy	NOUN
gs-4427	161	14	programs	program	NOUN
gs-4427	161	15	with	with	ADP
gs-4427	161	16	extended	extended	ADJ
gs-4427	161	17	follow	follow	NOUN
gs-4427	161	18	-	-	PUNCT
gs-4427	161	19	up	up	NOUN
gs-4427	161	20	,	,	PUNCT
gs-4427	161	21	the	the	DET
gs-4427	161	22	theoretical	theoretical	ADJ
gs-4427	161	23	potential	potential	NOUN
gs-4427	161	24	for	for	ADP
gs-4427	161	25	delayed	delay	VERB
gs-4427	161	26	adverse	adverse	ADJ
gs-4427	161	27	events	event	NOUN
gs-4427	161	28	including	include	VERB
gs-4427	161	29	insertional	insertional	ADJ
gs-4427	161	30	mutagenesis	mutagenesis	NOUN
gs-4427	161	31	leading	lead	VERB
gs-4427	161	32	to	to	ADP
gs-4427	161	33	cancer	cancer	NOUN
gs-4427	161	34	,	,	PUNCT
gs-4427	161	35	late	late	ADJ
gs-4427	161	36	-	-	PUNCT
gs-4427	161	37	onset	onset	NOUN
gs-4427	161	38	immune	immune	ADJ
gs-4427	161	39	responses	response	NOUN
gs-4427	161	40	,	,	PUNCT
gs-4427	161	41	or	or	CCONJ
gs-4427	161	42	unexpected	unexpected	ADJ
gs-4427	161	43	off	off	ADP
gs-4427	161	44	-	-	PUNCT
gs-4427	161	45	target	target	NOUN
gs-4427	161	46	effects	effect	NOUN
gs-4427	161	47	from	from	ADP
gs-4427	161	48	gene	gene	NOUN
gs-4427	161	49	editing	editing	NOUN
gs-4427	161	50	maintain	maintain	VERB
gs-4427	161	51	the	the	DET
gs-4427	161	52	need	need	NOUN
gs-4427	161	53	for	for	ADP
gs-4427	161	54	vigilant	vigilant	ADJ
gs-4427	161	55	long	long	ADJ
gs-4427	161	56	-	-	PUNCT
gs-4427	161	57	term	term	NOUN
gs-4427	161	58	monitoring	monitoring	NOUN
gs-4427	161	59	.	.	PUNCT
gs-4427	162	1	the	the	DET
gs-4427	162	2	development	development	NOUN
gs-4427	162	3	of	of	ADP
gs-4427	162	4	registry	registry	NOUN
gs-4427	162	5	systems	system	NOUN
gs-4427	162	6	and	and	CCONJ
gs-4427	162	7	streamlined	streamlined	ADJ
gs-4427	162	8	follow	follow	NOUN
gs-4427	162	9	-	-	PUNCT
gs-4427	162	10	up	up	ADP
gs-4427	162	11	procedures	procedure	NOUN
gs-4427	162	12	aim	aim	VERB
gs-4427	162	13	to	to	PART
gs-4427	162	14	minimize	minimize	VERB
gs-4427	162	15	patient	patient	ADJ
gs-4427	162	16	burden	burden	NOUN
gs-4427	162	17	while	while	SCONJ
gs-4427	162	18	maintaining	maintain	VERB
gs-4427	162	19	safety	safety	NOUN
gs-4427	162	20	oversight	oversight	NOUN
gs-4427	162	21	but	but	CCONJ
gs-4427	162	22	ensuring	ensure	VERB
gs-4427	162	23	high	high	ADJ
gs-4427	162	24	rates	rate	NOUN
gs-4427	162	25	of	of	ADP
gs-4427	162	26	long	long	ADJ
gs-4427	162	27	-	-	PUNCT
gs-4427	162	28	term	term	NOUN
gs-4427	162	29	follow	follow	NOUN
gs-4427	162	30	-	-	PUNCT
gs-4427	162	31	up	up	ADP
gs-4427	162	32	completion	completion	NOUN
gs-4427	162	33	remains	remain	VERB
gs-4427	162	34	challenging	challenge	VERB
gs-4427	162	35	as	as	SCONJ
gs-4427	162	36	patients	patient	NOUN
gs-4427	162	37	appropriately	appropriately	ADV
gs-4427	162	38	prioritize	prioritize	VERB
gs-4427	162	39	resuming	resume	VERB
gs-4427	162	40	normal	normal	ADJ
gs-4427	162	41	lives	life	NOUN
gs-4427	162	42	after	after	ADP
gs-4427	162	43	successful	successful	ADJ
gs-4427	162	44	treatment	treatment	NOUN
gs-4427	162	45	over	over	ADP
gs-4427	162	46	continued	continue	VERB
gs-4427	162	47	clinical	clinical	ADJ
gs-4427	162	48	visits	visit	NOUN
gs-4427	162	49	and	and	CCONJ
gs-4427	162	50	testing	testing	NOUN
gs-4427	162	51	.	.	PUNCT
gs-4427	163	1	discussion	discussion	NOUN
gs-4427	163	2	the	the	DET
gs-4427	163	3	rapid	rapid	ADJ
gs-4427	163	4	maturation	maturation	NOUN
gs-4427	163	5	of	of	ADP
gs-4427	163	6	gene	gene	NOUN
gs-4427	163	7	therapy	therapy	NOUN
gs-4427	163	8	represents	represent	VERB
gs-4427	163	9	one	one	NUM
gs-4427	163	10	of	of	ADP
gs-4427	163	11	the	the	DET
gs-4427	163	12	most	most	ADV
gs-4427	163	13	consequential	consequential	ADJ
gs-4427	163	14	paradigm	paradigm	NOUN
gs-4427	163	15	shifts	shift	NOUN
gs-4427	163	16	in	in	ADP
gs-4427	163	17	contemporary	contemporary	ADJ
gs-4427	163	18	biomedical	biomedical	ADJ
gs-4427	163	19	science	science	NOUN
gs-4427	163	20	,	,	PUNCT
gs-4427	163	21	redefining	redefine	VERB
gs-4427	163	22	therapeutic	therapeutic	ADJ
gs-4427	163	23	strategy	strategy	NOUN
gs-4427	163	24	by	by	ADP
gs-4427	163	25	directly	directly	ADV
gs-4427	163	26	addressing	address	VERB
gs-4427	163	27	disease	disease	NOUN
gs-4427	163	28	causation	causation	NOUN
gs-4427	163	29	at	at	ADP
gs-4427	163	30	the	the	DET
gs-4427	163	31	genomic	genomic	NOUN
gs-4427	163	32	and	and	CCONJ
gs-4427	163	33	molecular	molecular	ADJ
gs-4427	163	34	levels	level	NOUN
gs-4427	163	35	.	.	PUNCT
gs-4427	164	1	the	the	DET
gs-4427	164	2	findings	finding	NOUN
gs-4427	164	3	and	and	CCONJ
gs-4427	164	4	developments	development	NOUN
gs-4427	164	5	synthesized	synthesize	VERB
gs-4427	164	6	in	in	ADP
gs-4427	164	7	this	this	DET
gs-4427	164	8	review	review	NOUN
gs-4427	164	9	collectively	collectively	ADV
gs-4427	164	10	demonstrate	demonstrate	VERB
gs-4427	164	11	that	that	SCONJ
gs-4427	164	12	gene	gene	NOUN
gs-4427	164	13	therapy	therapy	NOUN
gs-4427	164	14	has	have	AUX
gs-4427	164	15	transitioned	transition	VERB
gs-4427	164	16	from	from	ADP
gs-4427	164	17	experimental	experimental	ADJ
gs-4427	164	18	novelty	novelty	NOUN
gs-4427	164	19	to	to	ADP
gs-4427	164	20	a	a	DET
gs-4427	164	21	clinically	clinically	ADV
gs-4427	164	22	actionable	actionable	ADJ
gs-4427	164	23	and	and	CCONJ
gs-4427	164	24	increasingly	increasingly	ADV
gs-4427	164	25	standardized	standardized	ADJ
gs-4427	164	26	modality	modality	NOUN
gs-4427	164	27	.	.	PUNCT
gs-4427	165	1	this	this	DET
gs-4427	165	2	transition	transition	NOUN
gs-4427	165	3	reflects	reflect	VERB
gs-4427	165	4	not	not	PART
gs-4427	165	5	only	only	ADV
gs-4427	165	6	technological	technological	ADJ
gs-4427	165	7	innovation	innovation	NOUN
gs-4427	165	8	but	but	CCONJ
gs-4427	165	9	also	also	ADV
gs-4427	165	10	a	a	DET
gs-4427	165	11	deeper	deep	ADJ
gs-4427	165	12	understanding	understanding	NOUN
gs-4427	165	13	of	of	ADP
gs-4427	165	14	disease	disease	NOUN
gs-4427	165	15	biology	biology	NOUN
gs-4427	165	16	,	,	PUNCT
gs-4427	165	17	immune	immune	ADJ
gs-4427	165	18	regulation	regulation	NOUN
gs-4427	165	19	,	,	PUNCT
gs-4427	165	20	manufacturing	manufacturing	NOUN
gs-4427	165	21	science	science	NOUN
gs-4427	165	22	,	,	PUNCT
gs-4427	165	23	and	and	CCONJ
gs-4427	165	24	georgian	georgian	PROPN
gs-4427	165	25	scientists/	scientists/	NUM
gs-4427	165	26	.	.	PUNCT
gs-4427	166	1	7	7	NUM
gs-4427	166	2	n	n	DET
gs-4427	166	3	4	4	NUM
gs-4427	166	4	,	,	PUNCT
gs-4427	166	5	2025	2025	NUM
gs-4427	166	6	641	641	NUM
gs-4427	166	7	regulatory	regulatory	ADJ
gs-4427	166	8	governance	governance	NOUN
gs-4427	166	9	.	.	PUNCT
gs-4427	167	1	importantly	importantly	ADV
gs-4427	167	2	,	,	PUNCT
gs-4427	167	3	the	the	DET
gs-4427	167	4	present	present	ADJ
gs-4427	167	5	era	era	NOUN
gs-4427	167	6	of	of	ADP
gs-4427	167	7	gene	gene	NOUN
gs-4427	167	8	therapy	therapy	NOUN
gs-4427	167	9	is	be	AUX
gs-4427	167	10	characterized	characterize	VERB
gs-4427	167	11	not	not	PART
gs-4427	167	12	by	by	ADP
gs-4427	167	13	a	a	DET
gs-4427	167	14	single	single	ADJ
gs-4427	167	15	dominant	dominant	ADJ
gs-4427	167	16	technology	technology	NOUN
gs-4427	167	17	but	but	CCONJ
gs-4427	167	18	by	by	ADP
gs-4427	167	19	a	a	DET
gs-4427	167	20	diversified	diversified	ADJ
gs-4427	167	21	portfolio	portfolio	NOUN
gs-4427	167	22	of	of	ADP
gs-4427	167	23	platforms	platform	NOUN
gs-4427	167	24	tailored	tailor	VERB
gs-4427	167	25	to	to	ADP
gs-4427	167	26	specific	specific	ADJ
gs-4427	167	27	biological	biological	ADJ
gs-4427	167	28	contexts	context	NOUN
gs-4427	167	29	and	and	CCONJ
gs-4427	167	30	therapeutic	therapeutic	ADJ
gs-4427	167	31	objectives	objective	NOUN
gs-4427	167	32	.	.	PUNCT
gs-4427	168	1	one	one	NUM
gs-4427	168	2	of	of	ADP
gs-4427	168	3	the	the	DET
gs-4427	168	4	most	most	ADV
gs-4427	168	5	significant	significant	ADJ
gs-4427	168	6	insights	insight	NOUN
gs-4427	168	7	emerging	emerge	VERB
gs-4427	168	8	from	from	ADP
gs-4427	168	9	recent	recent	ADJ
gs-4427	168	10	clinical	clinical	ADJ
gs-4427	168	11	experience	experience	NOUN
gs-4427	168	12	is	be	AUX
gs-4427	168	13	that	that	PRON
gs-4427	168	14	successful	successful	ADJ
gs-4427	168	15	gene	gene	NOUN
gs-4427	168	16	therapy	therapy	NOUN
gs-4427	168	17	depends	depend	VERB
gs-4427	168	18	fundamentally	fundamentally	ADV
gs-4427	168	19	on	on	ADP
gs-4427	168	20	the	the	DET
gs-4427	168	21	alignment	alignment	NOUN
gs-4427	168	22	between	between	ADP
gs-4427	168	23	disease	disease	NOUN
gs-4427	168	24	biology	biology	NOUN
gs-4427	168	25	and	and	CCONJ
gs-4427	168	26	therapeutic	therapeutic	ADJ
gs-4427	168	27	modality	modality	NOUN
gs-4427	168	28	.	.	PUNCT
gs-4427	169	1	monogenic	monogenic	ADJ
gs-4427	169	2	disorders	disorder	NOUN
gs-4427	169	3	affecting	affect	VERB
gs-4427	169	4	accessible	accessible	ADJ
gs-4427	169	5	or	or	CCONJ
gs-4427	169	6	renewable	renewable	ADJ
gs-4427	169	7	tissues	tissue	NOUN
gs-4427	169	8	,	,	PUNCT
gs-4427	169	9	such	such	ADJ
gs-4427	169	10	as	as	ADP
gs-4427	169	11	hematopoietic	hematopoietic	ADJ
gs-4427	169	12	stem	stem	NOUN
gs-4427	169	13	cells	cell	NOUN
gs-4427	169	14	,	,	PUNCT
gs-4427	169	15	hepatocytes	hepatocyte	NOUN
gs-4427	169	16	,	,	PUNCT
gs-4427	169	17	and	and	CCONJ
gs-4427	169	18	retinal	retinal	ADJ
gs-4427	169	19	cells	cell	NOUN
gs-4427	169	20	,	,	PUNCT
gs-4427	169	21	have	have	AUX
gs-4427	169	22	proven	prove	VERB
gs-4427	169	23	most	most	ADV
gs-4427	169	24	amenable	amenable	ADJ
gs-4427	169	25	to	to	ADP
gs-4427	169	26	early	early	ADJ
gs-4427	169	27	gene	gene	NOUN
gs-4427	169	28	therapy	therapy	NOUN
gs-4427	169	29	success	success	NOUN
gs-4427	169	30	.	.	PUNCT
gs-4427	170	1	in	in	ADP
gs-4427	170	2	these	these	DET
gs-4427	170	3	settings	setting	NOUN
gs-4427	170	4	,	,	PUNCT
gs-4427	170	5	partial	partial	ADJ
gs-4427	170	6	restoration	restoration	NOUN
gs-4427	170	7	of	of	ADP
gs-4427	170	8	protein	protein	NOUN
gs-4427	170	9	function	function	NOUN
gs-4427	170	10	often	often	ADV
gs-4427	170	11	yields	yield	VERB
gs-4427	170	12	disproportionate	disproportionate	ADJ
gs-4427	170	13	clinical	clinical	ADJ
gs-4427	170	14	benefit	benefit	NOUN
gs-4427	170	15	,	,	PUNCT
gs-4427	170	16	allowing	allow	VERB
gs-4427	170	17	therapeutic	therapeutic	ADJ
gs-4427	170	18	efficacy	efficacy	NOUN
gs-4427	170	19	even	even	ADV
gs-4427	170	20	when	when	SCONJ
gs-4427	170	21	transgene	transgene	ADJ
gs-4427	170	22	expression	expression	NOUN
gs-4427	170	23	does	do	AUX
gs-4427	170	24	not	not	PART
gs-4427	170	25	fully	fully	ADV
gs-4427	170	26	replicate	replicate	VERB
gs-4427	170	27	physiological	physiological	ADJ
gs-4427	170	28	levels	level	NOUN
gs-4427	170	29	.	.	PUNCT
gs-4427	171	1	this	this	DET
gs-4427	171	2	principle	principle	NOUN
gs-4427	171	3	has	have	AUX
gs-4427	171	4	been	be	AUX
gs-4427	171	5	clearly	clearly	ADV
gs-4427	171	6	demonstrated	demonstrate	VERB
gs-4427	171	7	in	in	ADP
gs-4427	171	8	hemophilia	hemophilia	PROPN
gs-4427	171	9	,	,	PUNCT
gs-4427	171	10	sickle	sickle	NOUN
gs-4427	171	11	cell	cell	NOUN
gs-4427	171	12	disease	disease	NOUN
gs-4427	171	13	,	,	PUNCT
gs-4427	171	14	and	and	CCONJ
gs-4427	171	15	inherited	inherit	VERB
gs-4427	171	16	retinal	retinal	ADJ
gs-4427	171	17	dystrophies	dystrophy	NOUN
gs-4427	171	18	,	,	PUNCT
gs-4427	171	19	where	where	SCONJ
gs-4427	171	20	modest	modest	ADJ
gs-4427	171	21	genetic	genetic	ADJ
gs-4427	171	22	correction	correction	NOUN
gs-4427	171	23	produces	produce	VERB
gs-4427	171	24	dramatic	dramatic	ADJ
gs-4427	171	25	improvements	improvement	NOUN
gs-4427	171	26	in	in	ADP
gs-4427	171	27	quality	quality	NOUN
gs-4427	171	28	of	of	ADP
gs-4427	171	29	life	life	NOUN
gs-4427	171	30	and	and	CCONJ
gs-4427	171	31	disease	disease	NOUN
gs-4427	171	32	burden	burden	NOUN
gs-4427	171	33	.	.	PUNCT
gs-4427	172	1	these	these	DET
gs-4427	172	2	successes	success	NOUN
gs-4427	172	3	underscore	underscore	VERB
gs-4427	172	4	the	the	DET
gs-4427	172	5	importance	importance	NOUN
gs-4427	172	6	of	of	ADP
gs-4427	172	7	strategic	strategic	ADJ
gs-4427	172	8	disease	disease	NOUN
gs-4427	172	9	selection	selection	NOUN
gs-4427	172	10	and	and	CCONJ
gs-4427	172	11	biological	biological	ADJ
gs-4427	172	12	feasibility	feasibility	NOUN
gs-4427	172	13	in	in	ADP
gs-4427	172	14	gene	gene	NOUN
gs-4427	172	15	therapy	therapy	NOUN
gs-4427	172	16	development	development	NOUN
gs-4427	172	17	.	.	PUNCT
gs-4427	173	1	viral	viral	ADJ
gs-4427	173	2	vector	vector	NOUN
gs-4427	173	3	–	–	PUNCT
gs-4427	173	4	mediated	mediate	VERB
gs-4427	173	5	gene	gene	NOUN
gs-4427	173	6	delivery	delivery	NOUN
gs-4427	173	7	,	,	PUNCT
gs-4427	173	8	particularly	particularly	ADV
gs-4427	173	9	using	use	VERB
gs-4427	173	10	adeno	adeno	NOUN
gs-4427	173	11	-	-	PUNCT
gs-4427	173	12	associated	associate	VERB
gs-4427	173	13	virus	virus	NOUN
gs-4427	173	14	and	and	CCONJ
gs-4427	173	15	lentiviral	lentiviral	ADJ
gs-4427	173	16	systems	system	NOUN
gs-4427	173	17	,	,	PUNCT
gs-4427	173	18	remains	remain	VERB
gs-4427	173	19	the	the	DET
gs-4427	173	20	backbone	backbone	NOUN
gs-4427	173	21	of	of	ADP
gs-4427	173	22	current	current	ADJ
gs-4427	173	23	clinical	clinical	ADJ
gs-4427	173	24	gene	gene	NOUN
gs-4427	173	25	therapy	therapy	NOUN
gs-4427	173	26	.	.	PUNCT
gs-4427	174	1	aav	aav	NOUN
gs-4427	174	2	-	-	PUNCT
gs-4427	174	3	based	base	VERB
gs-4427	174	4	in	in	ADP
gs-4427	174	5	vivo	vivo	ADJ
gs-4427	174	6	therapies	therapy	NOUN
gs-4427	174	7	have	have	AUX
gs-4427	174	8	established	establish	VERB
gs-4427	174	9	a	a	DET
gs-4427	174	10	strong	strong	ADJ
gs-4427	174	11	safety	safety	NOUN
gs-4427	174	12	and	and	CCONJ
gs-4427	174	13	efficacy	efficacy	NOUN
gs-4427	174	14	profile	profile	NOUN
gs-4427	174	15	,	,	PUNCT
gs-4427	174	16	especially	especially	ADV
gs-4427	174	17	in	in	ADP
gs-4427	174	18	nondividing	nondivide	VERB
gs-4427	174	19	tissues	tissue	NOUN
gs-4427	174	20	,	,	PUNCT
gs-4427	174	21	validating	validate	VERB
gs-4427	174	22	episomal	episomal	ADJ
gs-4427	174	23	persistence	persistence	NOUN
gs-4427	174	24	as	as	ADP
gs-4427	174	25	a	a	DET
gs-4427	174	26	viable	viable	ADJ
gs-4427	174	27	strategy	strategy	NOUN
gs-4427	174	28	for	for	ADP
gs-4427	174	29	long	long	ADJ
gs-4427	174	30	-	-	PUNCT
gs-4427	174	31	term	term	NOUN
gs-4427	174	32	therapeutic	therapeutic	ADJ
gs-4427	174	33	expression	expression	NOUN
gs-4427	174	34	.	.	PUNCT
gs-4427	175	1	however	however	ADV
gs-4427	175	2	,	,	PUNCT
gs-4427	175	3	emerging	emerge	VERB
gs-4427	175	4	data	datum	NOUN
gs-4427	175	5	also	also	ADV
gs-4427	175	6	highlight	highlight	VERB
gs-4427	175	7	intrinsic	intrinsic	ADJ
gs-4427	175	8	limitations	limitation	NOUN
gs-4427	175	9	of	of	ADP
gs-4427	175	10	aav	aav	NOUN
gs-4427	175	11	platforms	platform	NOUN
gs-4427	175	12	,	,	PUNCT
gs-4427	175	13	including	include	VERB
gs-4427	175	14	packaging	packaging	NOUN
gs-4427	175	15	size	size	NOUN
gs-4427	175	16	constraints	constraint	NOUN
gs-4427	175	17	,	,	PUNCT
gs-4427	175	18	susceptibility	susceptibility	NOUN
gs-4427	175	19	to	to	PART
gs-4427	175	20	pre	pre	VERB
gs-4427	175	21	-	-	ADJ
gs-4427	175	22	existing	exist	VERB
gs-4427	175	23	neutralizing	neutralizing	ADJ
gs-4427	175	24	antibodies	antibody	NOUN
gs-4427	175	25	,	,	PUNCT
gs-4427	175	26	and	and	CCONJ
gs-4427	175	27	challenges	challenge	NOUN
gs-4427	175	28	related	relate	VERB
gs-4427	175	29	to	to	PART
gs-4427	175	30	re	re	VERB
gs-4427	175	31	-	-	VERB
gs-4427	175	32	dosing	dosing	ADJ
gs-4427	175	33	.	.	PUNCT
gs-4427	176	1	these	these	DET
gs-4427	176	2	limitations	limitation	NOUN
gs-4427	176	3	suggest	suggest	VERB
gs-4427	176	4	that	that	SCONJ
gs-4427	176	5	while	while	SCONJ
gs-4427	176	6	aav	aav	NOUN
gs-4427	176	7	vectors	vector	NOUN
gs-4427	176	8	will	will	AUX
gs-4427	176	9	continue	continue	VERB
gs-4427	176	10	to	to	PART
gs-4427	176	11	dominate	dominate	VERB
gs-4427	176	12	certain	certain	ADJ
gs-4427	176	13	therapeutic	therapeutic	ADJ
gs-4427	176	14	areas	area	NOUN
gs-4427	176	15	,	,	PUNCT
gs-4427	176	16	they	they	PRON
gs-4427	176	17	are	be	AUX
gs-4427	176	18	unlikely	unlikely	ADJ
gs-4427	176	19	to	to	PART
gs-4427	176	20	represent	represent	VERB
gs-4427	176	21	a	a	DET
gs-4427	176	22	universal	universal	ADJ
gs-4427	176	23	solution	solution	NOUN
gs-4427	176	24	.	.	PUNCT
gs-4427	177	1	continued	continue	VERB
gs-4427	177	2	capsid	capsid	PROPN
gs-4427	177	3	engineering	engineering	NOUN
gs-4427	177	4	,	,	PUNCT
gs-4427	177	5	serotype	serotype	ADJ
gs-4427	177	6	diversification	diversification	NOUN
gs-4427	177	7	,	,	PUNCT
gs-4427	177	8	and	and	CCONJ
gs-4427	177	9	immune	immune	ADJ
gs-4427	177	10	evasion	evasion	NOUN
gs-4427	177	11	strategies	strategy	NOUN
gs-4427	177	12	will	will	AUX
gs-4427	177	13	be	be	AUX
gs-4427	177	14	necessary	necessary	ADJ
gs-4427	177	15	to	to	PART
gs-4427	177	16	extend	extend	VERB
gs-4427	177	17	aav	aav	NOUN
gs-4427	177	18	applicability	applicability	NOUN
gs-4427	177	19	to	to	ADP
gs-4427	177	20	broader	broad	ADJ
gs-4427	177	21	patient	patient	ADJ
gs-4427	177	22	populations	population	NOUN
gs-4427	177	23	and	and	CCONJ
gs-4427	177	24	disease	disease	NOUN
gs-4427	177	25	indications	indication	NOUN
gs-4427	177	26	.	.	PUNCT
gs-4427	178	1	lentiviral	lentiviral	ADJ
gs-4427	178	2	vectors	vector	NOUN
gs-4427	178	3	,	,	PUNCT
gs-4427	178	4	by	by	ADP
gs-4427	178	5	contrast	contrast	NOUN
gs-4427	178	6	,	,	PUNCT
gs-4427	178	7	have	have	AUX
gs-4427	178	8	demonstrated	demonstrate	VERB
gs-4427	178	9	particular	particular	ADJ
gs-4427	178	10	strength	strength	NOUN
gs-4427	178	11	in	in	ADP
gs-4427	178	12	ex	ex	PRON
gs-4427	178	13	vivo	vivo	ADJ
gs-4427	178	14	applications	application	NOUN
gs-4427	178	15	requiring	require	VERB
gs-4427	178	16	stable	stable	ADJ
gs-4427	178	17	genomic	genomic	NOUN
gs-4427	178	18	integration	integration	NOUN
gs-4427	178	19	and	and	CCONJ
gs-4427	178	20	long	long	ADJ
gs-4427	178	21	-	-	PUNCT
gs-4427	178	22	term	term	NOUN
gs-4427	178	23	expression	expression	NOUN
gs-4427	178	24	through	through	ADP
gs-4427	178	25	cell	cell	NOUN
gs-4427	178	26	division	division	NOUN
gs-4427	178	27	.	.	PUNCT
gs-4427	179	1	their	their	PRON
gs-4427	179	2	success	success	NOUN
gs-4427	179	3	in	in	ADP
gs-4427	179	4	hematopoietic	hematopoietic	ADJ
gs-4427	179	5	stem	stem	NOUN
gs-4427	179	6	cell	cell	NOUN
gs-4427	179	7	modification	modification	NOUN
gs-4427	179	8	and	and	CCONJ
gs-4427	179	9	car	car	NOUN
gs-4427	179	10	-	-	PUNCT
gs-4427	179	11	t	t	NOUN
gs-4427	179	12	cell	cell	NOUN
gs-4427	179	13	therapy	therapy	NOUN
gs-4427	179	14	illustrates	illustrate	VERB
gs-4427	179	15	how	how	SCONJ
gs-4427	179	16	controlled	control	VERB
gs-4427	179	17	integration	integration	NOUN
gs-4427	179	18	,	,	PUNCT
gs-4427	179	19	when	when	SCONJ
gs-4427	179	20	combined	combine	VERB
gs-4427	179	21	with	with	ADP
gs-4427	179	22	improved	improved	ADJ
gs-4427	179	23	vector	vector	NOUN
gs-4427	179	24	design	design	NOUN
gs-4427	179	25	and	and	CCONJ
gs-4427	179	26	rigorous	rigorous	ADJ
gs-4427	179	27	safety	safety	NOUN
gs-4427	179	28	testing	testing	NOUN
gs-4427	179	29	,	,	PUNCT
gs-4427	179	30	can	can	AUX
gs-4427	179	31	yield	yield	VERB
gs-4427	179	32	durable	durable	ADJ
gs-4427	179	33	benefit	benefit	NOUN
gs-4427	179	34	with	with	ADP
gs-4427	179	35	acceptable	acceptable	ADJ
gs-4427	179	36	risk	risk	NOUN
gs-4427	179	37	.	.	PUNCT
gs-4427	180	1	nevertheless	nevertheless	ADV
gs-4427	180	2	,	,	PUNCT
gs-4427	180	3	integration	integration	NOUN
gs-4427	180	4	-	-	PUNCT
gs-4427	180	5	associated	associate	VERB
gs-4427	180	6	genotoxicity	genotoxicity	NOUN
gs-4427	180	7	,	,	PUNCT
gs-4427	180	8	although	although	SCONJ
gs-4427	180	9	substantially	substantially	ADV
gs-4427	180	10	mitigated	mitigate	VERB
gs-4427	180	11	compared	compare	VERB
gs-4427	180	12	to	to	ADP
gs-4427	180	13	earlier	early	ADJ
gs-4427	180	14	retroviral	retroviral	ADJ
gs-4427	180	15	systems	system	NOUN
gs-4427	180	16	,	,	PUNCT
gs-4427	180	17	remains	remain	VERB
gs-4427	180	18	a	a	DET
gs-4427	180	19	theoretical	theoretical	ADJ
gs-4427	180	20	concern	concern	NOUN
gs-4427	180	21	requiring	require	VERB
gs-4427	180	22	long	long	ADJ
gs-4427	180	23	-	-	PUNCT
gs-4427	180	24	term	term	NOUN
gs-4427	180	25	surveillance	surveillance	NOUN
gs-4427	180	26	.	.	PUNCT
gs-4427	181	1	the	the	DET
gs-4427	181	2	balance	balance	NOUN
gs-4427	181	3	between	between	ADP
gs-4427	181	4	therapeutic	therapeutic	ADJ
gs-4427	181	5	durability	durability	NOUN
gs-4427	181	6	and	and	CCONJ
gs-4427	181	7	genomic	genomic	NOUN
gs-4427	181	8	safety	safety	NOUN
gs-4427	181	9	continues	continue	VERB
gs-4427	181	10	to	to	PART
gs-4427	181	11	shape	shape	VERB
gs-4427	181	12	vector	vector	NOUN
gs-4427	181	13	choice	choice	NOUN
gs-4427	181	14	and	and	CCONJ
gs-4427	181	15	clinical	clinical	ADJ
gs-4427	181	16	decision	decision	NOUN
gs-4427	181	17	-	-	PUNCT
gs-4427	181	18	making	making	NOUN
gs-4427	181	19	,	,	PUNCT
gs-4427	181	20	particularly	particularly	ADV
gs-4427	181	21	as	as	SCONJ
gs-4427	181	22	genome	genome	NOUN
gs-4427	181	23	editing	editing	NOUN
gs-4427	181	24	technologies	technology	NOUN
gs-4427	181	25	offer	offer	VERB
gs-4427	181	26	alternative	alternative	ADJ
gs-4427	181	27	routes	route	NOUN
gs-4427	181	28	to	to	ADP
gs-4427	181	29	stable	stable	ADJ
gs-4427	181	30	genetic	genetic	ADJ
gs-4427	181	31	correction	correction	NOUN
gs-4427	181	32	without	without	ADP
gs-4427	181	33	reliance	reliance	NOUN
gs-4427	181	34	on	on	ADP
gs-4427	181	35	random	random	ADJ
gs-4427	181	36	integration	integration	NOUN
gs-4427	181	37	.	.	PUNCT
gs-4427	182	1	the	the	DET
gs-4427	182	2	emergence	emergence	NOUN
gs-4427	182	3	of	of	ADP
gs-4427	182	4	crispr	crispr	NOUN
gs-4427	182	5	-	-	PUNCT
gs-4427	182	6	based	base	VERB
gs-4427	182	7	genome	genome	NOUN
gs-4427	182	8	editing	editing	NOUN
gs-4427	182	9	represents	represent	VERB
gs-4427	182	10	a	a	DET
gs-4427	182	11	conceptual	conceptual	ADJ
gs-4427	182	12	inflection	inflection	NOUN
gs-4427	182	13	point	point	NOUN
gs-4427	182	14	in	in	ADP
gs-4427	182	15	gene	gene	NOUN
gs-4427	182	16	therapy	therapy	NOUN
gs-4427	182	17	,	,	PUNCT
gs-4427	182	18	shifting	shift	VERB
gs-4427	182	19	the	the	DET
gs-4427	182	20	field	field	NOUN
gs-4427	182	21	from	from	ADP
gs-4427	182	22	gene	gene	NOUN
gs-4427	182	23	supplementation	supplementation	NOUN
gs-4427	182	24	toward	toward	ADP
gs-4427	182	25	precise	precise	ADJ
gs-4427	182	26	genetic	genetic	ADJ
gs-4427	182	27	repair	repair	NOUN
gs-4427	182	28	.	.	PUNCT
gs-4427	183	1	unlike	unlike	ADP
gs-4427	183	2	traditional	traditional	ADJ
gs-4427	183	3	gene	gene	NOUN
gs-4427	183	4	addition	addition	NOUN
gs-4427	183	5	approaches	approach	NOUN
gs-4427	183	6	,	,	PUNCT
gs-4427	183	7	genome	genome	NOUN
gs-4427	183	8	editing	editing	NOUN
gs-4427	183	9	enables	enable	VERB
gs-4427	183	10	modification	modification	NOUN
gs-4427	183	11	of	of	ADP
gs-4427	183	12	endogenous	endogenous	ADJ
gs-4427	183	13	loci	locus	NOUN
gs-4427	183	14	,	,	PUNCT
gs-4427	183	15	preserving	preserve	VERB
gs-4427	183	16	physiological	physiological	ADJ
gs-4427	183	17	gene	gene	NOUN
gs-4427	183	18	regulation	regulation	NOUN
gs-4427	183	19	and	and	CCONJ
gs-4427	183	20	minimizing	minimize	VERB
gs-4427	183	21	risks	risk	NOUN
gs-4427	183	22	associated	associate	VERB
gs-4427	183	23	with	with	ADP
gs-4427	183	24	ectopic	ectopic	ADJ
gs-4427	183	25	expression	expression	NOUN
gs-4427	183	26	.	.	PUNCT
gs-4427	184	1	clinical	clinical	ADJ
gs-4427	184	2	validation	validation	NOUN
gs-4427	184	3	of	of	ADP
gs-4427	184	4	crispr	crispr	NOUN
gs-4427	184	5	-	-	PUNCT
gs-4427	184	6	based	base	VERB
gs-4427	184	7	therapies	therapy	NOUN
gs-4427	184	8	for	for	ADP
gs-4427	184	9	georgian	georgian	NOUN
gs-4427	184	10	scientists/	scientists/	NUM
gs-4427	184	11	.	.	PUNCT
gs-4427	185	1	7	7	NUM
gs-4427	185	2	n	n	DET
gs-4427	185	3	4	4	NUM
gs-4427	185	4	,	,	PUNCT
gs-4427	185	5	2025	2025	NUM
gs-4427	185	6	642	642	NUM
gs-4427	185	7	hemoglobinopathies	hemoglobinopathy	NOUN
gs-4427	185	8	has	have	AUX
gs-4427	185	9	demonstrated	demonstrate	VERB
gs-4427	185	10	that	that	SCONJ
gs-4427	185	11	targeted	target	VERB
gs-4427	185	12	disruption	disruption	NOUN
gs-4427	185	13	of	of	ADP
gs-4427	185	14	regulatory	regulatory	ADJ
gs-4427	185	15	elements	element	NOUN
gs-4427	185	16	can	can	AUX
gs-4427	185	17	achieve	achieve	VERB
gs-4427	185	18	therapeutic	therapeutic	ADJ
gs-4427	185	19	outcomes	outcome	NOUN
gs-4427	185	20	comparable	comparable	ADJ
gs-4427	185	21	to	to	ADP
gs-4427	185	22	gene	gene	NOUN
gs-4427	185	23	replacement	replacement	NOUN
gs-4427	185	24	while	while	SCONJ
gs-4427	185	25	potentially	potentially	ADV
gs-4427	185	26	offering	offer	VERB
gs-4427	185	27	improved	improved	ADJ
gs-4427	185	28	durability	durability	NOUN
gs-4427	185	29	.	.	PUNCT
gs-4427	186	1	these	these	DET
gs-4427	186	2	successes	success	NOUN
gs-4427	186	3	also	also	ADV
gs-4427	186	4	illustrate	illustrate	VERB
gs-4427	186	5	the	the	DET
gs-4427	186	6	power	power	NOUN
gs-4427	186	7	of	of	ADP
gs-4427	186	8	leveraging	leverage	VERB
gs-4427	186	9	developmental	developmental	ADJ
gs-4427	186	10	biology	biology	NOUN
gs-4427	186	11	,	,	PUNCT
gs-4427	186	12	such	such	ADJ
gs-4427	186	13	as	as	ADP
gs-4427	186	14	fetal	fetal	ADJ
gs-4427	186	15	hemoglobin	hemoglobin	NOUN
gs-4427	186	16	reactivation	reactivation	NOUN
gs-4427	186	17	,	,	PUNCT
gs-4427	186	18	to	to	PART
gs-4427	186	19	achieve	achieve	VERB
gs-4427	186	20	therapeutic	therapeutic	ADJ
gs-4427	186	21	benefit	benefit	NOUN
gs-4427	186	22	without	without	ADP
gs-4427	186	23	direct	direct	ADJ
gs-4427	186	24	correction	correction	NOUN
gs-4427	186	25	of	of	ADP
gs-4427	186	26	disease	disease	NOUN
gs-4427	186	27	-	-	PUNCT
gs-4427	186	28	causing	cause	VERB
gs-4427	186	29	mutations	mutation	NOUN
gs-4427	186	30	.	.	PUNCT
gs-4427	187	1	despite	despite	SCONJ
gs-4427	187	2	its	its	PRON
gs-4427	187	3	transformative	transformative	ADJ
gs-4427	187	4	potential	potential	NOUN
gs-4427	187	5	,	,	PUNCT
gs-4427	187	6	genome	genome	NOUN
gs-4427	187	7	editing	editing	NOUN
gs-4427	187	8	introduces	introduce	NOUN
gs-4427	187	9	novel	novel	ADJ
gs-4427	187	10	challenges	challenge	NOUN
gs-4427	187	11	that	that	PRON
gs-4427	187	12	distinguish	distinguish	VERB
gs-4427	187	13	it	it	PRON
gs-4427	187	14	from	from	ADP
gs-4427	187	15	earlier	early	ADJ
gs-4427	187	16	gene	gene	NOUN
gs-4427	187	17	therapy	therapy	NOUN
gs-4427	187	18	paradigms	paradigm	VERB
gs-4427	187	19	.	.	PUNCT
gs-4427	188	1	off	off	ADP
gs-4427	188	2	-	-	PUNCT
gs-4427	188	3	target	target	NOUN
gs-4427	188	4	effects	effect	NOUN
gs-4427	188	5	,	,	PUNCT
gs-4427	188	6	unintended	unintended	ADJ
gs-4427	188	7	genomic	genomic	ADJ
gs-4427	188	8	rearrangements	rearrangement	NOUN
gs-4427	188	9	,	,	PUNCT
gs-4427	188	10	and	and	CCONJ
gs-4427	188	11	immune	immune	ADJ
gs-4427	188	12	responses	response	NOUN
gs-4427	188	13	to	to	ADP
gs-4427	188	14	bacterial	bacterial	ADJ
gs-4427	188	15	-	-	PUNCT
gs-4427	188	16	derived	derive	VERB
gs-4427	188	17	nucleases	nuclease	NOUN
gs-4427	188	18	necessitate	necessitate	ADJ
gs-4427	188	19	rigorous	rigorous	ADJ
gs-4427	188	20	preclinical	preclinical	ADJ
gs-4427	188	21	validation	validation	NOUN
gs-4427	188	22	and	and	CCONJ
gs-4427	188	23	conservative	conservative	ADJ
gs-4427	188	24	clinical	clinical	ADJ
gs-4427	188	25	implementation	implementation	NOUN
gs-4427	188	26	.	.	PUNCT
gs-4427	189	1	the	the	DET
gs-4427	189	2	development	development	NOUN
gs-4427	189	3	of	of	ADP
gs-4427	189	4	base	base	NOUN
gs-4427	189	5	editors	editor	NOUN
gs-4427	189	6	and	and	CCONJ
gs-4427	189	7	prime	prime	ADJ
gs-4427	189	8	editors	editor	NOUN
gs-4427	189	9	reflects	reflect	VERB
gs-4427	189	10	an	an	DET
gs-4427	189	11	ongoing	ongoing	ADJ
gs-4427	189	12	effort	effort	NOUN
gs-4427	189	13	to	to	PART
gs-4427	189	14	refine	refine	VERB
gs-4427	189	15	editing	edit	VERB
gs-4427	189	16	precision	precision	NOUN
gs-4427	189	17	while	while	SCONJ
gs-4427	189	18	minimizing	minimize	VERB
gs-4427	189	19	genotoxic	genotoxic	ADJ
gs-4427	189	20	risk	risk	NOUN
gs-4427	189	21	.	.	PUNCT
gs-4427	190	1	however	however	ADV
gs-4427	190	2	,	,	PUNCT
gs-4427	190	3	clinical	clinical	ADJ
gs-4427	190	4	translation	translation	NOUN
gs-4427	190	5	of	of	ADP
gs-4427	190	6	these	these	DET
gs-4427	190	7	next	next	ADJ
gs-4427	190	8	-	-	PUNCT
gs-4427	190	9	generation	generation	NOUN
gs-4427	190	10	tools	tool	NOUN
gs-4427	190	11	will	will	AUX
gs-4427	190	12	require	require	VERB
gs-4427	190	13	careful	careful	ADJ
gs-4427	190	14	assessment	assessment	NOUN
gs-4427	190	15	of	of	ADP
gs-4427	190	16	editing	edit	VERB
gs-4427	190	17	efficiency	efficiency	NOUN
gs-4427	190	18	,	,	PUNCT
gs-4427	190	19	delivery	delivery	NOUN
gs-4427	190	20	feasibility	feasibility	NOUN
gs-4427	190	21	,	,	PUNCT
gs-4427	190	22	and	and	CCONJ
gs-4427	190	23	long	long	ADJ
gs-4427	190	24	-	-	PUNCT
gs-4427	190	25	term	term	NOUN
gs-4427	190	26	safety	safety	NOUN
gs-4427	190	27	,	,	PUNCT
gs-4427	190	28	particularly	particularly	ADV
gs-4427	190	29	for	for	ADP
gs-4427	190	30	in	in	ADP
gs-4427	190	31	vivo	vivo	ADJ
gs-4427	190	32	applications	application	NOUN
gs-4427	190	33	where	where	SCONJ
gs-4427	190	34	reversibility	reversibility	NOUN
gs-4427	190	35	is	be	AUX
gs-4427	190	36	not	not	PART
gs-4427	190	37	possible	possible	ADJ
gs-4427	190	38	.	.	PUNCT
gs-4427	191	1	as	as	SCONJ
gs-4427	191	2	genome	genome	NOUN
gs-4427	191	3	editing	editing	NOUN
gs-4427	191	4	technologies	technology	NOUN
gs-4427	191	5	evolve	evolve	VERB
gs-4427	191	6	,	,	PUNCT
gs-4427	191	7	their	their	PRON
gs-4427	191	8	integration	integration	NOUN
gs-4427	191	9	into	into	ADP
gs-4427	191	10	clinical	clinical	ADJ
gs-4427	191	11	practice	practice	NOUN
gs-4427	191	12	will	will	AUX
gs-4427	191	13	demand	demand	VERB
gs-4427	191	14	heightened	heighten	VERB
gs-4427	191	15	ethical	ethical	ADJ
gs-4427	191	16	scrutiny	scrutiny	NOUN
gs-4427	191	17	and	and	CCONJ
gs-4427	191	18	regulatory	regulatory	ADJ
gs-4427	191	19	oversight	oversight	NOUN
gs-4427	191	20	.	.	PUNCT
gs-4427	192	1	engineered	engineer	VERB
gs-4427	192	2	cell	cell	NOUN
gs-4427	192	3	therapies	therapy	NOUN
gs-4427	192	4	,	,	PUNCT
gs-4427	192	5	particularly	particularly	ADV
gs-4427	192	6	car	car	NOUN
gs-4427	192	7	-	-	PUNCT
gs-4427	192	8	t	t	NOUN
gs-4427	192	9	cells	cell	NOUN
gs-4427	192	10	,	,	PUNCT
gs-4427	192	11	represent	represent	VERB
gs-4427	192	12	one	one	NUM
gs-4427	192	13	of	of	ADP
gs-4427	192	14	the	the	DET
gs-4427	192	15	most	most	ADV
gs-4427	192	16	clinically	clinically	ADV
gs-4427	192	17	impactful	impactful	ADJ
gs-4427	192	18	applications	application	NOUN
gs-4427	192	19	of	of	ADP
gs-4427	192	20	gene	gene	NOUN
gs-4427	192	21	therapy	therapy	NOUN
gs-4427	192	22	to	to	ADP
gs-4427	192	23	date	date	NOUN
gs-4427	192	24	.	.	PUNCT
gs-4427	193	1	their	their	PRON
gs-4427	193	2	success	success	NOUN
gs-4427	193	3	challenges	challenge	VERB
gs-4427	193	4	traditional	traditional	ADJ
gs-4427	193	5	pharmacological	pharmacological	NOUN
gs-4427	193	6	models	model	NOUN
gs-4427	193	7	by	by	ADP
gs-4427	193	8	introducing	introduce	VERB
gs-4427	193	9	living	living	NOUN
gs-4427	193	10	,	,	PUNCT
gs-4427	193	11	self	self	NOUN
gs-4427	193	12	-	-	PUNCT
gs-4427	193	13	amplifying	amplify	VERB
gs-4427	193	14	therapeutic	therapeutic	ADJ
gs-4427	193	15	agents	agent	NOUN
gs-4427	193	16	capable	capable	ADJ
gs-4427	193	17	of	of	ADP
gs-4427	193	18	long	long	ADJ
gs-4427	193	19	-	-	PUNCT
gs-4427	193	20	term	term	NOUN
gs-4427	193	21	persistence	persistence	NOUN
gs-4427	193	22	and	and	CCONJ
gs-4427	193	23	dynamic	dynamic	ADJ
gs-4427	193	24	response	response	NOUN
gs-4427	193	25	to	to	ADP
gs-4427	193	26	disease	disease	NOUN
gs-4427	193	27	.	.	PUNCT
gs-4427	194	1	the	the	DET
gs-4427	194	2	durability	durability	NOUN
gs-4427	194	3	of	of	ADP
gs-4427	194	4	remission	remission	NOUN
gs-4427	194	5	observed	observe	VERB
gs-4427	194	6	in	in	ADP
gs-4427	194	7	certain	certain	ADJ
gs-4427	194	8	hematological	hematological	ADJ
gs-4427	194	9	malignancies	malignancy	NOUN
gs-4427	194	10	suggests	suggest	VERB
gs-4427	194	11	that	that	SCONJ
gs-4427	194	12	gene	gene	NOUN
gs-4427	194	13	-	-	PUNCT
gs-4427	194	14	modified	modify	VERB
gs-4427	194	15	immune	immune	ADJ
gs-4427	194	16	cells	cell	NOUN
gs-4427	194	17	can	can	AUX
gs-4427	194	18	function	function	VERB
gs-4427	194	19	as	as	ADP
gs-4427	194	20	autonomous	autonomous	ADJ
gs-4427	194	21	therapeutic	therapeutic	ADJ
gs-4427	194	22	systems	system	NOUN
gs-4427	194	23	rather	rather	ADV
gs-4427	194	24	than	than	ADP
gs-4427	194	25	transient	transient	ADJ
gs-4427	194	26	interventions	intervention	NOUN
gs-4427	194	27	.	.	PUNCT
gs-4427	195	1	however	however	ADV
gs-4427	195	2	,	,	PUNCT
gs-4427	195	3	car	car	NOUN
gs-4427	195	4	-	-	PUNCT
gs-4427	195	5	t	t	NOUN
gs-4427	195	6	therapy	therapy	NOUN
gs-4427	195	7	also	also	ADV
gs-4427	195	8	exemplifies	exemplify	VERB
gs-4427	195	9	the	the	DET
gs-4427	195	10	complexity	complexity	NOUN
gs-4427	195	11	of	of	ADP
gs-4427	195	12	translating	translate	VERB
gs-4427	195	13	gene	gene	NOUN
gs-4427	195	14	therapy	therapy	NOUN
gs-4427	195	15	into	into	ADP
gs-4427	195	16	routine	routine	ADJ
gs-4427	195	17	clinical	clinical	ADJ
gs-4427	195	18	practice	practice	NOUN
gs-4427	195	19	,	,	PUNCT
gs-4427	195	20	given	give	VERB
gs-4427	195	21	its	its	PRON
gs-4427	195	22	association	association	NOUN
gs-4427	195	23	with	with	ADP
gs-4427	195	24	unique	unique	ADJ
gs-4427	195	25	toxicities	toxicity	NOUN
gs-4427	195	26	,	,	PUNCT
gs-4427	195	27	individualized	individualized	ADJ
gs-4427	195	28	manufacturing	manufacturing	NOUN
gs-4427	195	29	requirements	requirement	NOUN
gs-4427	195	30	,	,	PUNCT
gs-4427	195	31	and	and	CCONJ
gs-4427	195	32	substantial	substantial	ADJ
gs-4427	195	33	cost	cost	NOUN
gs-4427	195	34	.	.	PUNCT
gs-4427	196	1	expanding	expand	VERB
gs-4427	196	2	car	car	NOUN
gs-4427	196	3	-	-	PUNCT
gs-4427	196	4	t	t	NOUN
gs-4427	196	5	approaches	approach	NOUN
gs-4427	196	6	to	to	ADP
gs-4427	196	7	solid	solid	ADJ
gs-4427	196	8	tumors	tumor	NOUN
gs-4427	196	9	and	and	CCONJ
gs-4427	196	10	non	non	ADJ
gs-4427	196	11	-	-	ADJ
gs-4427	196	12	oncologic	oncologic	ADJ
gs-4427	196	13	indications	indication	NOUN
gs-4427	196	14	will	will	AUX
gs-4427	196	15	require	require	VERB
gs-4427	196	16	further	further	ADJ
gs-4427	196	17	advances	advance	NOUN
gs-4427	196	18	in	in	ADP
gs-4427	196	19	target	target	NOUN
gs-4427	196	20	selection	selection	NOUN
gs-4427	196	21	,	,	PUNCT
gs-4427	196	22	cell	cell	NOUN
gs-4427	196	23	engineering	engineering	NOUN
gs-4427	196	24	,	,	PUNCT
gs-4427	196	25	and	and	CCONJ
gs-4427	196	26	safety	safety	NOUN
gs-4427	196	27	management	management	NOUN
gs-4427	196	28	.	.	PUNCT
gs-4427	197	1	manufacturing	manufacturing	NOUN
gs-4427	197	2	science	science	NOUN
gs-4427	197	3	has	have	AUX
gs-4427	197	4	emerged	emerge	VERB
gs-4427	197	5	as	as	ADP
gs-4427	197	6	a	a	DET
gs-4427	197	7	central	central	ADJ
gs-4427	197	8	determinant	determinant	ADJ
gs-4427	197	9	of	of	ADP
gs-4427	197	10	gene	gene	NOUN
gs-4427	197	11	therapy	therapy	NOUN
gs-4427	197	12	accessibility	accessibility	NOUN
gs-4427	197	13	and	and	CCONJ
gs-4427	197	14	scalability	scalability	NOUN
gs-4427	197	15	.	.	PUNCT
gs-4427	198	1	the	the	DET
gs-4427	198	2	individualized	individualized	ADJ
gs-4427	198	3	nature	nature	NOUN
gs-4427	198	4	of	of	ADP
gs-4427	198	5	autologous	autologous	ADJ
gs-4427	198	6	cell	cell	NOUN
gs-4427	198	7	therapies	therapy	NOUN
gs-4427	198	8	and	and	CCONJ
gs-4427	198	9	the	the	DET
gs-4427	198	10	technical	technical	ADJ
gs-4427	198	11	complexity	complexity	NOUN
gs-4427	198	12	of	of	ADP
gs-4427	198	13	viral	viral	ADJ
gs-4427	198	14	vector	vector	NOUN
gs-4427	198	15	production	production	NOUN
gs-4427	198	16	impose	impose	VERB
gs-4427	198	17	significant	significant	ADJ
gs-4427	198	18	logistical	logistical	ADJ
gs-4427	198	19	and	and	CCONJ
gs-4427	198	20	economic	economic	ADJ
gs-4427	198	21	constraints	constraint	NOUN
gs-4427	198	22	.	.	PUNCT
gs-4427	199	1	current	current	ADJ
gs-4427	199	2	manufacturing	manufacturing	NOUN
gs-4427	199	3	paradigms	paradigm	NOUN
gs-4427	199	4	,	,	PUNCT
gs-4427	199	5	while	while	SCONJ
gs-4427	199	6	effective	effective	ADJ
gs-4427	199	7	for	for	ADP
gs-4427	199	8	limited	limited	ADJ
gs-4427	199	9	patient	patient	ADJ
gs-4427	199	10	populations	population	NOUN
gs-4427	199	11	,	,	PUNCT
gs-4427	199	12	are	be	AUX
gs-4427	199	13	unlikely	unlikely	ADJ
gs-4427	199	14	to	to	PART
gs-4427	199	15	sustain	sustain	VERB
gs-4427	199	16	widespread	widespread	ADJ
gs-4427	199	17	adoption	adoption	NOUN
gs-4427	199	18	without	without	ADP
gs-4427	199	19	substantial	substantial	ADJ
gs-4427	199	20	innovation	innovation	NOUN
gs-4427	199	21	.	.	PUNCT
gs-4427	200	1	automation	automation	NOUN
gs-4427	200	2	,	,	PUNCT
gs-4427	200	3	standardization	standardization	NOUN
gs-4427	200	4	,	,	PUNCT
gs-4427	200	5	and	and	CCONJ
gs-4427	200	6	decentralization	decentralization	NOUN
gs-4427	200	7	of	of	ADP
gs-4427	200	8	manufacturing	manufacturing	NOUN
gs-4427	200	9	processes	process	NOUN
gs-4427	200	10	represent	represent	VERB
gs-4427	200	11	critical	critical	ADJ
gs-4427	200	12	priorities	priority	NOUN
gs-4427	200	13	for	for	ADP
gs-4427	200	14	the	the	DET
gs-4427	200	15	field	field	NOUN
gs-4427	200	16	.	.	PUNCT
gs-4427	201	1	moreover	moreover	ADV
gs-4427	201	2	,	,	PUNCT
gs-4427	201	3	manufacturing	manufacture	VERB
gs-4427	201	4	reliability	reliability	NOUN
gs-4427	201	5	directly	directly	ADV
gs-4427	201	6	influences	influence	VERB
gs-4427	201	7	clinical	clinical	ADJ
gs-4427	201	8	outcomes	outcome	NOUN
gs-4427	201	9	,	,	PUNCT
gs-4427	201	10	as	as	SCONJ
gs-4427	201	11	delays	delay	NOUN
gs-4427	201	12	or	or	CCONJ
gs-4427	201	13	failures	failure	NOUN
gs-4427	201	14	can	can	AUX
gs-4427	201	15	be	be	AUX
gs-4427	201	16	life	life	NOUN
gs-4427	201	17	-	-	PUNCT
gs-4427	201	18	threatening	threaten	VERB
gs-4427	201	19	for	for	ADP
gs-4427	201	20	patients	patient	NOUN
gs-4427	201	21	with	with	ADP
gs-4427	201	22	rapidly	rapidly	ADV
gs-4427	201	23	progressing	progress	VERB
gs-4427	201	24	disease	disease	NOUN
gs-4427	201	25	.	.	PUNCT
gs-4427	202	1	thus	thus	ADV
gs-4427	202	2	,	,	PUNCT
gs-4427	202	3	manufacturing	manufacturing	NOUN
gs-4427	202	4	should	should	AUX
gs-4427	202	5	be	be	AUX
gs-4427	202	6	viewed	view	VERB
gs-4427	202	7	not	not	PART
gs-4427	202	8	merely	merely	ADV
gs-4427	202	9	as	as	ADP
gs-4427	202	10	a	a	DET
gs-4427	202	11	technical	technical	ADJ
gs-4427	202	12	consideration	consideration	NOUN
gs-4427	202	13	but	but	CCONJ
gs-4427	202	14	as	as	ADP
gs-4427	202	15	an	an	DET
gs-4427	202	16	integral	integral	ADJ
gs-4427	202	17	component	component	NOUN
gs-4427	202	18	of	of	ADP
gs-4427	202	19	therapeutic	therapeutic	ADJ
gs-4427	202	20	efficacy	efficacy	NOUN
gs-4427	202	21	.	.	PUNCT
gs-4427	203	1	economic	economic	ADJ
gs-4427	203	2	considerations	consideration	NOUN
gs-4427	203	3	increasingly	increasingly	ADV
gs-4427	203	4	shape	shape	VERB
gs-4427	203	5	the	the	DET
gs-4427	203	6	gene	gene	NOUN
gs-4427	203	7	therapy	therapy	NOUN
gs-4427	203	8	discourse	discourse	NOUN
gs-4427	203	9	,	,	PUNCT
gs-4427	203	10	particularly	particularly	ADV
gs-4427	203	11	as	as	SCONJ
gs-4427	203	12	approved	approve	VERB
gs-4427	203	13	products	product	NOUN
gs-4427	203	14	command	command	VERB
gs-4427	203	15	unprecedented	unprecedented	ADJ
gs-4427	203	16	prices	price	NOUN
gs-4427	203	17	.	.	PUNCT
gs-4427	204	1	while	while	SCONJ
gs-4427	204	2	long	long	ADJ
gs-4427	204	3	-	-	PUNCT
gs-4427	204	4	term	term	NOUN
gs-4427	204	5	cost	cost	NOUN
gs-4427	204	6	-	-	PUNCT
gs-4427	204	7	effectiveness	effectiveness	NOUN
gs-4427	204	8	analyses	analysis	NOUN
gs-4427	204	9	often	often	ADV
gs-4427	204	10	support	support	VERB
gs-4427	204	11	the	the	DET
gs-4427	204	12	value	value	NOUN
gs-4427	204	13	of	of	ADP
gs-4427	204	14	potentially	potentially	ADV
gs-4427	204	15	curative	curative	ADJ
gs-4427	204	16	therapies	therapy	NOUN
gs-4427	204	17	,	,	PUNCT
gs-4427	204	18	the	the	DET
gs-4427	204	19	upfront	upfront	ADJ
gs-4427	204	20	financial	financial	ADJ
gs-4427	204	21	burden	burden	NOUN
gs-4427	204	22	poses	pose	VERB
gs-4427	204	23	systemic	systemic	ADJ
gs-4427	204	24	challenges	challenge	NOUN
gs-4427	204	25	for	for	ADP
gs-4427	204	26	healthcare	healthcare	NOUN
gs-4427	204	27	systems	system	NOUN
gs-4427	204	28	.	.	PUNCT
gs-4427	205	1	this	this	DET
gs-4427	205	2	tension	tension	NOUN
gs-4427	205	3	highlights	highlight	VERB
gs-4427	205	4	a	a	DET
gs-4427	205	5	georgian	georgian	NOUN
gs-4427	205	6	scientists/	scientists/	NUM
gs-4427	205	7	.	.	PUNCT
gs-4427	206	1	7	7	NUM
gs-4427	206	2	n	n	DET
gs-4427	206	3	4	4	NUM
gs-4427	206	4	,	,	PUNCT
gs-4427	206	5	2025	2025	NUM
gs-4427	206	6	643	643	NUM
gs-4427	206	7	fundamental	fundamental	ADJ
gs-4427	206	8	misalignment	misalignment	NOUN
gs-4427	206	9	between	between	ADP
gs-4427	206	10	traditional	traditional	ADJ
gs-4427	206	11	reimbursement	reimbursement	NOUN
gs-4427	206	12	models	model	NOUN
gs-4427	206	13	and	and	CCONJ
gs-4427	206	14	the	the	DET
gs-4427	206	15	economic	economic	ADJ
gs-4427	206	16	reality	reality	NOUN
gs-4427	206	17	of	of	ADP
gs-4427	206	18	one	one	NUM
gs-4427	206	19	-	-	PUNCT
gs-4427	206	20	time	time	NOUN
gs-4427	206	21	,	,	PUNCT
gs-4427	206	22	high	high	ADJ
gs-4427	206	23	-	-	PUNCT
gs-4427	206	24	impact	impact	NOUN
gs-4427	206	25	treatments	treatment	NOUN
gs-4427	206	26	.	.	PUNCT
gs-4427	207	1	outcomes	outcome	NOUN
gs-4427	207	2	-	-	PUNCT
gs-4427	207	3	based	base	VERB
gs-4427	207	4	payment	payment	NOUN
gs-4427	207	5	structures	structure	NOUN
gs-4427	207	6	,	,	PUNCT
gs-4427	207	7	risksharing	riskshare	VERB
gs-4427	207	8	agreements	agreement	NOUN
gs-4427	207	9	,	,	PUNCT
gs-4427	207	10	and	and	CCONJ
gs-4427	207	11	annuity	annuity	NOUN
gs-4427	207	12	-	-	PUNCT
gs-4427	207	13	style	style	NOUN
gs-4427	207	14	reimbursement	reimbursement	NOUN
gs-4427	207	15	models	model	NOUN
gs-4427	207	16	represent	represent	VERB
gs-4427	207	17	promising	promising	ADJ
gs-4427	207	18	approaches	approach	NOUN
gs-4427	207	19	to	to	ADP
gs-4427	207	20	reconciling	reconcile	VERB
gs-4427	207	21	innovation	innovation	NOUN
gs-4427	207	22	with	with	ADP
gs-4427	207	23	affordability	affordability	NOUN
gs-4427	207	24	.	.	PUNCT
gs-4427	208	1	however	however	ADV
gs-4427	208	2	,	,	PUNCT
gs-4427	208	3	their	their	PRON
gs-4427	208	4	implementation	implementation	NOUN
gs-4427	208	5	requires	require	VERB
gs-4427	208	6	coordination	coordination	NOUN
gs-4427	208	7	among	among	ADP
gs-4427	208	8	manufacturers	manufacturer	NOUN
gs-4427	208	9	,	,	PUNCT
gs-4427	208	10	payers	payer	NOUN
gs-4427	208	11	,	,	PUNCT
gs-4427	208	12	regulators	regulator	NOUN
gs-4427	208	13	,	,	PUNCT
gs-4427	208	14	and	and	CCONJ
gs-4427	208	15	clinicians	clinician	NOUN
gs-4427	208	16	,	,	PUNCT
gs-4427	208	17	as	as	ADV
gs-4427	208	18	well	well	ADV
gs-4427	208	19	as	as	ADP
gs-4427	208	20	robust	robust	ADJ
gs-4427	208	21	data	datum	NOUN
gs-4427	208	22	infrastructure	infrastructure	NOUN
gs-4427	208	23	to	to	PART
gs-4427	208	24	track	track	VERB
gs-4427	208	25	long	long	ADJ
gs-4427	208	26	-	-	PUNCT
gs-4427	208	27	term	term	NOUN
gs-4427	208	28	outcomes	outcome	NOUN
gs-4427	208	29	.	.	PUNCT
gs-4427	209	1	ethical	ethical	ADJ
gs-4427	209	2	and	and	CCONJ
gs-4427	209	3	societal	societal	ADJ
gs-4427	209	4	considerations	consideration	NOUN
gs-4427	209	5	are	be	AUX
gs-4427	209	6	inseparable	inseparable	ADJ
gs-4427	209	7	from	from	ADP
gs-4427	209	8	the	the	DET
gs-4427	209	9	scientific	scientific	ADJ
gs-4427	209	10	evolution	evolution	NOUN
gs-4427	209	11	of	of	ADP
gs-4427	209	12	gene	gene	NOUN
gs-4427	209	13	therapy	therapy	NOUN
gs-4427	209	14	.	.	PUNCT
gs-4427	210	1	as	as	SCONJ
gs-4427	210	2	interventions	intervention	NOUN
gs-4427	210	3	become	become	VERB
gs-4427	210	4	more	more	ADV
gs-4427	210	5	permanent	permanent	ADJ
gs-4427	210	6	and	and	CCONJ
gs-4427	210	7	potentially	potentially	ADV
gs-4427	210	8	heritable	heritable	ADJ
gs-4427	210	9	in	in	ADP
gs-4427	210	10	effect	effect	NOUN
gs-4427	210	11	,	,	PUNCT
gs-4427	210	12	the	the	DET
gs-4427	210	13	responsibility	responsibility	NOUN
gs-4427	210	14	to	to	PART
gs-4427	210	15	ensure	ensure	VERB
gs-4427	210	16	informed	informed	ADJ
gs-4427	210	17	consent	consent	NOUN
gs-4427	210	18	,	,	PUNCT
gs-4427	210	19	transparency	transparency	NOUN
gs-4427	210	20	,	,	PUNCT
gs-4427	210	21	and	and	CCONJ
gs-4427	210	22	equitable	equitable	ADJ
gs-4427	210	23	access	access	NOUN
gs-4427	210	24	becomes	become	VERB
gs-4427	210	25	paramount	paramount	ADJ
gs-4427	210	26	.	.	PUNCT
gs-4427	211	1	although	although	SCONJ
gs-4427	211	2	current	current	ADJ
gs-4427	211	3	clinical	clinical	ADJ
gs-4427	211	4	applications	application	NOUN
gs-4427	211	5	are	be	AUX
gs-4427	211	6	limited	limit	VERB
gs-4427	211	7	to	to	ADP
gs-4427	211	8	somatic	somatic	ADJ
gs-4427	211	9	gene	gene	NOUN
gs-4427	211	10	therapy	therapy	NOUN
gs-4427	211	11	,	,	PUNCT
gs-4427	211	12	public	public	ADJ
gs-4427	211	13	concern	concern	NOUN
gs-4427	211	14	regarding	regard	VERB
gs-4427	211	15	germline	germline	NOUN
gs-4427	211	16	modification	modification	NOUN
gs-4427	211	17	underscores	underscore	VERB
gs-4427	211	18	the	the	DET
gs-4427	211	19	need	need	NOUN
gs-4427	211	20	for	for	ADP
gs-4427	211	21	clear	clear	ADJ
gs-4427	211	22	ethical	ethical	ADJ
gs-4427	211	23	boundaries	boundary	NOUN
gs-4427	211	24	and	and	CCONJ
gs-4427	211	25	international	international	ADJ
gs-4427	211	26	consensus	consensus	NOUN
gs-4427	211	27	.	.	PUNCT
gs-4427	212	1	furthermore	furthermore	ADV
gs-4427	212	2	,	,	PUNCT
gs-4427	212	3	disparities	disparity	NOUN
gs-4427	212	4	in	in	ADP
gs-4427	212	5	access	access	NOUN
gs-4427	212	6	to	to	ADP
gs-4427	212	7	gene	gene	NOUN
gs-4427	212	8	therapy	therapy	NOUN
gs-4427	212	9	,	,	PUNCT
gs-4427	212	10	both	both	CCONJ
gs-4427	212	11	within	within	ADP
gs-4427	212	12	and	and	CCONJ
gs-4427	212	13	between	between	ADP
gs-4427	212	14	countries	country	NOUN
gs-4427	212	15	,	,	PUNCT
gs-4427	212	16	risk	risk	NOUN
gs-4427	212	17	exacerbating	exacerbate	VERB
gs-4427	212	18	existing	exist	VERB
gs-4427	212	19	health	health	NOUN
gs-4427	212	20	inequities	inequity	NOUN
gs-4427	212	21	if	if	SCONJ
gs-4427	212	22	not	not	PART
gs-4427	212	23	proactively	proactively	ADV
gs-4427	212	24	addressed	address	VERB
gs-4427	212	25	.	.	PUNCT
gs-4427	213	1	ensuring	ensure	VERB
gs-4427	213	2	that	that	SCONJ
gs-4427	213	3	gene	gene	NOUN
gs-4427	213	4	therapy	therapy	NOUN
gs-4427	213	5	advances	advance	NOUN
gs-4427	213	6	benefit	benefit	VERB
gs-4427	213	7	diverse	diverse	ADJ
gs-4427	213	8	populations	population	NOUN
gs-4427	213	9	requires	require	VERB
gs-4427	213	10	deliberate	deliberate	ADJ
gs-4427	213	11	policy	policy	NOUN
gs-4427	213	12	planning	planning	NOUN
gs-4427	213	13	,	,	PUNCT
gs-4427	213	14	global	global	ADJ
gs-4427	213	15	collaboration	collaboration	NOUN
gs-4427	213	16	,	,	PUNCT
gs-4427	213	17	and	and	CCONJ
gs-4427	213	18	investment	investment	NOUN
gs-4427	213	19	in	in	ADP
gs-4427	213	20	healthcare	healthcare	PROPN
gs-4427	213	21	infrastructure	infrastructure	NOUN
gs-4427	213	22	.	.	PUNCT
gs-4427	214	1	regulatory	regulatory	ADJ
gs-4427	214	2	frameworks	framework	NOUN
gs-4427	214	3	have	have	AUX
gs-4427	214	4	evolved	evolve	VERB
gs-4427	214	5	in	in	ADP
gs-4427	214	6	response	response	NOUN
gs-4427	214	7	to	to	ADP
gs-4427	214	8	the	the	DET
gs-4427	214	9	unique	unique	ADJ
gs-4427	214	10	characteristics	characteristic	NOUN
gs-4427	214	11	of	of	ADP
gs-4427	214	12	gene	gene	NOUN
gs-4427	214	13	therapy	therapy	NOUN
gs-4427	214	14	,	,	PUNCT
gs-4427	214	15	adopting	adopt	VERB
gs-4427	214	16	adaptive	adaptive	ADJ
gs-4427	214	17	pathways	pathway	NOUN
gs-4427	214	18	that	that	PRON
gs-4427	214	19	balance	balance	VERB
gs-4427	214	20	early	early	ADJ
gs-4427	214	21	access	access	NOUN
gs-4427	214	22	with	with	ADP
gs-4427	214	23	safety	safety	NOUN
gs-4427	214	24	oversight	oversight	NOUN
gs-4427	214	25	.	.	PUNCT
gs-4427	215	1	accelerated	accelerate	VERB
gs-4427	215	2	approval	approval	NOUN
gs-4427	215	3	mechanisms	mechanism	NOUN
gs-4427	215	4	,	,	PUNCT
gs-4427	215	5	acceptance	acceptance	NOUN
gs-4427	215	6	of	of	ADP
gs-4427	215	7	surrogate	surrogate	ADJ
gs-4427	215	8	endpoints	endpoint	NOUN
gs-4427	215	9	,	,	PUNCT
gs-4427	215	10	and	and	CCONJ
gs-4427	215	11	platform	platform	NOUN
gs-4427	215	12	-	-	PUNCT
gs-4427	215	13	based	base	VERB
gs-4427	215	14	regulatory	regulatory	ADJ
gs-4427	215	15	approaches	approach	NOUN
gs-4427	215	16	reflect	reflect	VERB
gs-4427	215	17	recognition	recognition	NOUN
gs-4427	215	18	that	that	SCONJ
gs-4427	215	19	traditional	traditional	ADJ
gs-4427	215	20	drug	drug	NOUN
gs-4427	215	21	development	development	NOUN
gs-4427	215	22	models	model	NOUN
gs-4427	215	23	are	be	AUX
gs-4427	215	24	illsuited	illsuite	VERB
gs-4427	215	25	to	to	ADP
gs-4427	215	26	rare	rare	ADJ
gs-4427	215	27	and	and	CCONJ
gs-4427	215	28	life	life	NOUN
gs-4427	215	29	-	-	PUNCT
gs-4427	215	30	threatening	threaten	VERB
gs-4427	215	31	genetic	genetic	ADJ
gs-4427	215	32	diseases	disease	NOUN
gs-4427	215	33	.	.	PUNCT
gs-4427	216	1	nevertheless	nevertheless	ADV
gs-4427	216	2	,	,	PUNCT
gs-4427	216	3	regulatory	regulatory	ADJ
gs-4427	216	4	flexibility	flexibility	NOUN
gs-4427	216	5	must	must	AUX
gs-4427	216	6	be	be	AUX
gs-4427	216	7	accompanied	accompany	VERB
gs-4427	216	8	by	by	ADP
gs-4427	216	9	rigorous	rigorous	ADJ
gs-4427	216	10	post	post	ADJ
gs-4427	216	11	-	-	ADJ
gs-4427	216	12	marketing	marketing	ADJ
gs-4427	216	13	surveillance	surveillance	NOUN
gs-4427	216	14	to	to	PART
gs-4427	216	15	identify	identify	VERB
gs-4427	216	16	late	late	ADV
gs-4427	216	17	-	-	PUNCT
gs-4427	216	18	emerging	emerge	VERB
gs-4427	216	19	risks	risk	NOUN
gs-4427	216	20	and	and	CCONJ
gs-4427	216	21	ensure	ensure	VERB
gs-4427	216	22	long	long	ADJ
gs-4427	216	23	-	-	PUNCT
gs-4427	216	24	term	term	NOUN
gs-4427	216	25	patient	patient	NOUN
gs-4427	216	26	safety	safety	NOUN
gs-4427	216	27	.	.	PUNCT
gs-4427	217	1	the	the	DET
gs-4427	217	2	requirement	requirement	NOUN
gs-4427	217	3	for	for	ADP
gs-4427	217	4	extended	extended	ADJ
gs-4427	217	5	follow	follow	NOUN
gs-4427	217	6	-	-	PUNCT
gs-4427	217	7	up	up	NOUN
gs-4427	217	8	underscores	underscore	VERB
gs-4427	217	9	the	the	DET
gs-4427	217	10	enduring	endure	VERB
gs-4427	217	11	responsibility	responsibility	NOUN
gs-4427	217	12	of	of	ADP
gs-4427	217	13	developers	developer	NOUN
gs-4427	217	14	and	and	CCONJ
gs-4427	217	15	healthcare	healthcare	PROPN
gs-4427	217	16	systems	system	NOUN
gs-4427	217	17	to	to	ADP
gs-4427	217	18	patients	patient	NOUN
gs-4427	217	19	receiving	receive	VERB
gs-4427	217	20	irreversible	irreversible	ADJ
gs-4427	217	21	genetic	genetic	ADJ
gs-4427	217	22	interventions	intervention	NOUN
gs-4427	217	23	.	.	PUNCT
gs-4427	218	1	from	from	ADP
gs-4427	218	2	a	a	DET
gs-4427	218	3	translational	translational	ADJ
gs-4427	218	4	perspective	perspective	NOUN
gs-4427	218	5	,	,	PUNCT
gs-4427	218	6	the	the	DET
gs-4427	218	7	success	success	NOUN
gs-4427	218	8	of	of	ADP
gs-4427	218	9	gene	gene	NOUN
gs-4427	218	10	therapy	therapy	NOUN
gs-4427	218	11	underscores	underscore	VERB
gs-4427	218	12	the	the	DET
gs-4427	218	13	importance	importance	NOUN
gs-4427	218	14	of	of	ADP
gs-4427	218	15	multidisciplinary	multidisciplinary	ADJ
gs-4427	218	16	collaboration	collaboration	NOUN
gs-4427	218	17	.	.	PUNCT
gs-4427	219	1	effective	effective	ADJ
gs-4427	219	2	development	development	NOUN
gs-4427	219	3	and	and	CCONJ
gs-4427	219	4	clinical	clinical	ADJ
gs-4427	219	5	implementation	implementation	NOUN
gs-4427	219	6	require	require	NOUN
gs-4427	219	7	integration	integration	NOUN
gs-4427	219	8	of	of	ADP
gs-4427	219	9	molecular	molecular	ADJ
gs-4427	219	10	biology	biology	NOUN
gs-4427	219	11	,	,	PUNCT
gs-4427	219	12	immunology	immunology	NOUN
gs-4427	219	13	,	,	PUNCT
gs-4427	219	14	clinical	clinical	ADJ
gs-4427	219	15	medicine	medicine	NOUN
gs-4427	219	16	,	,	PUNCT
gs-4427	219	17	pharmacy	pharmacy	NOUN
gs-4427	219	18	,	,	PUNCT
gs-4427	219	19	bioinformatics	bioinformatics	NOUN
gs-4427	219	20	,	,	PUNCT
gs-4427	219	21	ethics	ethic	NOUN
gs-4427	219	22	,	,	PUNCT
gs-4427	219	23	and	and	CCONJ
gs-4427	219	24	health	health	NOUN
gs-4427	219	25	economics	economic	NOUN
gs-4427	219	26	.	.	PUNCT
gs-4427	220	1	pharmacists	pharmacist	NOUN
gs-4427	220	2	and	and	CCONJ
gs-4427	220	3	clinical	clinical	ADJ
gs-4427	220	4	pharmacologists	pharmacologist	NOUN
gs-4427	220	5	,	,	PUNCT
gs-4427	220	6	in	in	ADP
gs-4427	220	7	particular	particular	ADJ
gs-4427	220	8	,	,	PUNCT
gs-4427	220	9	play	play	VERB
gs-4427	220	10	an	an	DET
gs-4427	220	11	increasingly	increasingly	ADV
gs-4427	220	12	important	important	ADJ
gs-4427	220	13	role	role	NOUN
gs-4427	220	14	in	in	ADP
gs-4427	220	15	gene	gene	NOUN
gs-4427	220	16	therapy	therapy	NOUN
gs-4427	220	17	administration	administration	NOUN
gs-4427	220	18	,	,	PUNCT
gs-4427	220	19	monitoring	monitoring	NOUN
gs-4427	220	20	,	,	PUNCT
gs-4427	220	21	and	and	CCONJ
gs-4427	220	22	patient	patient	ADJ
gs-4427	220	23	education	education	NOUN
gs-4427	220	24	,	,	PUNCT
gs-4427	220	25	reflecting	reflect	VERB
gs-4427	220	26	the	the	DET
gs-4427	220	27	convergence	convergence	NOUN
gs-4427	220	28	of	of	ADP
gs-4427	220	29	pharmacotherapy	pharmacotherapy	NOUN
gs-4427	220	30	and	and	CCONJ
gs-4427	220	31	genetic	genetic	ADJ
gs-4427	220	32	medicine	medicine	NOUN
gs-4427	220	33	.	.	PUNCT
gs-4427	221	1	education	education	NOUN
gs-4427	221	2	and	and	CCONJ
gs-4427	221	3	training	training	NOUN
gs-4427	221	4	programs	program	NOUN
gs-4427	221	5	must	must	AUX
gs-4427	221	6	evolve	evolve	VERB
gs-4427	221	7	accordingly	accordingly	ADV
gs-4427	221	8	to	to	PART
gs-4427	221	9	prepare	prepare	VERB
gs-4427	221	10	healthcare	healthcare	NOUN
gs-4427	221	11	professionals	professional	NOUN
gs-4427	221	12	for	for	ADP
gs-4427	221	13	this	this	DET
gs-4427	221	14	new	new	ADJ
gs-4427	221	15	therapeutic	therapeutic	ADJ
gs-4427	221	16	landscape	landscape	NOUN
gs-4427	221	17	.	.	PUNCT
gs-4427	222	1	looking	look	VERB
gs-4427	222	2	forward	forward	ADV
gs-4427	222	3	,	,	PUNCT
gs-4427	222	4	the	the	DET
gs-4427	222	5	future	future	NOUN
gs-4427	222	6	of	of	ADP
gs-4427	222	7	gene	gene	NOUN
gs-4427	222	8	therapy	therapy	NOUN
gs-4427	222	9	will	will	AUX
gs-4427	222	10	likely	likely	ADV
gs-4427	222	11	be	be	AUX
gs-4427	222	12	defined	define	VERB
gs-4427	222	13	by	by	ADP
gs-4427	222	14	convergence	convergence	NOUN
gs-4427	222	15	rather	rather	ADV
gs-4427	222	16	than	than	ADP
gs-4427	222	17	competition	competition	NOUN
gs-4427	222	18	among	among	ADP
gs-4427	222	19	platforms	platform	NOUN
gs-4427	222	20	.	.	PUNCT
gs-4427	223	1	hybrid	hybrid	ADJ
gs-4427	223	2	approaches	approach	NOUN
gs-4427	223	3	combining	combine	VERB
gs-4427	223	4	viral	viral	ADJ
gs-4427	223	5	delivery	delivery	NOUN
gs-4427	223	6	,	,	PUNCT
gs-4427	223	7	genome	genome	NOUN
gs-4427	223	8	editing	editing	NOUN
gs-4427	223	9	,	,	PUNCT
gs-4427	223	10	and	and	CCONJ
gs-4427	223	11	cell	cell	NOUN
gs-4427	223	12	engineering	engineering	NOUN
gs-4427	223	13	may	may	AUX
gs-4427	223	14	achieve	achieve	VERB
gs-4427	223	15	therapeutic	therapeutic	ADJ
gs-4427	223	16	outcomes	outcome	NOUN
gs-4427	223	17	unattainable	unattainable	ADJ
gs-4427	223	18	by	by	ADP
gs-4427	223	19	any	any	DET
gs-4427	223	20	single	single	ADJ
gs-4427	223	21	modality	modality	NOUN
gs-4427	223	22	.	.	PUNCT
gs-4427	224	1	advances	advance	NOUN
gs-4427	224	2	in	in	ADP
gs-4427	224	3	artificial	artificial	ADJ
gs-4427	224	4	intelligence	intelligence	NOUN
gs-4427	224	5	and	and	CCONJ
gs-4427	224	6	computational	computational	ADJ
gs-4427	224	7	biology	biology	NOUN
gs-4427	224	8	are	be	AUX
gs-4427	224	9	expected	expect	VERB
gs-4427	224	10	to	to	PART
gs-4427	224	11	accelerate	accelerate	VERB
gs-4427	224	12	vector	vector	NOUN
gs-4427	224	13	design	design	NOUN
gs-4427	224	14	,	,	PUNCT
gs-4427	224	15	target	target	NOUN
gs-4427	224	16	identification	identification	NOUN
gs-4427	224	17	,	,	PUNCT
gs-4427	224	18	and	and	CCONJ
gs-4427	224	19	risk	risk	NOUN
gs-4427	224	20	prediction	prediction	NOUN
gs-4427	224	21	,	,	PUNCT
gs-4427	224	22	further	far	ADV
gs-4427	224	23	enhancing	enhance	VERB
gs-4427	224	24	precision	precision	NOUN
gs-4427	224	25	and	and	CCONJ
gs-4427	224	26	safety	safety	NOUN
gs-4427	224	27	.	.	PUNCT
gs-4427	225	1	as	as	SCONJ
gs-4427	225	2	these	these	DET
gs-4427	225	3	innovations	innovation	NOUN
gs-4427	225	4	unfold	unfold	VERB
gs-4427	225	5	,	,	PUNCT
gs-4427	225	6	the	the	DET
gs-4427	225	7	central	central	ADJ
gs-4427	225	8	challenge	challenge	NOUN
gs-4427	225	9	will	will	AUX
gs-4427	225	10	be	be	AUX
gs-4427	225	11	to	to	PART
gs-4427	225	12	translate	translate	VERB
gs-4427	225	13	georgian	georgian	NOUN
gs-4427	225	14	scientists/	scientists/	NUM
gs-4427	225	15	.	.	PUNCT
gs-4427	226	1	7	7	NUM
gs-4427	226	2	n	n	DET
gs-4427	226	3	4	4	NUM
gs-4427	226	4	,	,	PUNCT
gs-4427	226	5	2025	2025	NUM
gs-4427	226	6	644	644	NUM
gs-4427	226	7	technological	technological	ADJ
gs-4427	226	8	capability	capability	NOUN
gs-4427	226	9	into	into	ADP
gs-4427	226	10	real	real	ADJ
gs-4427	226	11	-	-	PUNCT
gs-4427	226	12	world	world	NOUN
gs-4427	226	13	benefit	benefit	NOUN
gs-4427	226	14	while	while	SCONJ
gs-4427	226	15	maintaining	maintain	VERB
gs-4427	226	16	ethical	ethical	ADJ
gs-4427	226	17	integrity	integrity	NOUN
gs-4427	226	18	,	,	PUNCT
gs-4427	226	19	economic	economic	ADJ
gs-4427	226	20	sustainability	sustainability	NOUN
gs-4427	226	21	,	,	PUNCT
gs-4427	226	22	and	and	CCONJ
gs-4427	226	23	patient	patient	NOUN
gs-4427	226	24	-	-	PUNCT
gs-4427	226	25	centered	center	VERB
gs-4427	226	26	care	care	NOUN
gs-4427	226	27	.	.	PUNCT
gs-4427	227	1	gene	gene	NOUN
gs-4427	227	2	therapy	therapy	NOUN
gs-4427	227	3	stands	stand	VERB
gs-4427	227	4	at	at	ADP
gs-4427	227	5	a	a	DET
gs-4427	227	6	pivotal	pivotal	ADJ
gs-4427	227	7	juncture	juncture	NOUN
gs-4427	227	8	,	,	PUNCT
gs-4427	227	9	having	having	AUX
gs-4427	227	10	demonstrated	demonstrate	VERB
gs-4427	227	11	undeniable	undeniable	ADJ
gs-4427	227	12	clinical	clinical	ADJ
gs-4427	227	13	value	value	NOUN
gs-4427	227	14	while	while	SCONJ
gs-4427	227	15	confronting	confront	VERB
gs-4427	227	16	complex	complex	ADJ
gs-4427	227	17	challenges	challenge	NOUN
gs-4427	227	18	that	that	PRON
gs-4427	227	19	will	will	AUX
gs-4427	227	20	shape	shape	VERB
gs-4427	227	21	its	its	PRON
gs-4427	227	22	trajectory	trajectory	NOUN
gs-4427	227	23	for	for	ADP
gs-4427	227	24	decades	decade	NOUN
gs-4427	227	25	to	to	PART
gs-4427	227	26	come	come	VERB
gs-4427	227	27	.	.	PUNCT
gs-4427	228	1	the	the	DET
gs-4427	228	2	evidence	evidence	NOUN
gs-4427	228	3	reviewed	review	VERB
gs-4427	228	4	herein	herein	NOUN
gs-4427	228	5	supports	support	VERB
gs-4427	228	6	cautious	cautious	ADJ
gs-4427	228	7	optimism	optimism	NOUN
gs-4427	228	8	that	that	PRON
gs-4427	228	9	continued	continue	VERB
gs-4427	228	10	scientific	scientific	ADJ
gs-4427	228	11	innovation	innovation	NOUN
gs-4427	228	12	,	,	PUNCT
gs-4427	228	13	coupled	couple	VERB
gs-4427	228	14	with	with	ADP
gs-4427	228	15	thoughtful	thoughtful	ADJ
gs-4427	228	16	regulatory	regulatory	ADJ
gs-4427	228	17	and	and	CCONJ
gs-4427	228	18	policy	policy	NOUN
gs-4427	228	19	frameworks	framework	NOUN
gs-4427	228	20	,	,	PUNCT
gs-4427	228	21	will	will	AUX
gs-4427	228	22	enable	enable	VERB
gs-4427	228	23	gene	gene	NOUN
gs-4427	228	24	therapy	therapy	NOUN
gs-4427	228	25	to	to	PART
gs-4427	228	26	fulfill	fulfill	VERB
gs-4427	228	27	its	its	PRON
gs-4427	228	28	promise	promise	NOUN
gs-4427	228	29	as	as	ADP
gs-4427	228	30	a	a	DET
gs-4427	228	31	cornerstone	cornerstone	NOUN
gs-4427	228	32	of	of	ADP
gs-4427	228	33	precision	precision	NOUN
gs-4427	228	34	medicine	medicine	NOUN
gs-4427	228	35	.	.	PUNCT
gs-4427	229	1	the	the	DET
gs-4427	229	2	task	task	NOUN
gs-4427	229	3	ahead	ahead	ADV
gs-4427	229	4	lies	lie	VERB
gs-4427	229	5	not	not	PART
gs-4427	229	6	only	only	ADV
gs-4427	229	7	in	in	ADP
gs-4427	229	8	advancing	advance	VERB
gs-4427	229	9	technology	technology	NOUN
gs-4427	229	10	but	but	CCONJ
gs-4427	229	11	in	in	ADP
gs-4427	229	12	ensuring	ensure	VERB
gs-4427	229	13	that	that	SCONJ
gs-4427	229	14	its	its	PRON
gs-4427	229	15	benefits	benefit	NOUN
gs-4427	229	16	are	be	AUX
gs-4427	229	17	delivered	deliver	VERB
gs-4427	229	18	safely	safely	ADV
gs-4427	229	19	,	,	PUNCT
gs-4427	229	20	equitably	equitably	ADV
gs-4427	229	21	,	,	PUNCT
gs-4427	229	22	and	and	CCONJ
gs-4427	229	23	responsibly	responsibly	ADV
gs-4427	229	24	to	to	ADP
gs-4427	229	25	patients	patient	NOUN
gs-4427	229	26	worldwide	worldwide	ADV
gs-4427	229	27	.	.	PUNCT
gs-4427	230	1	therapeutic	therapeutic	ADJ
gs-4427	230	2	platform	platform	NOUN
gs-4427	230	3	maturation	maturation	NOUN
gs-4427	230	4	and	and	CCONJ
gs-4427	230	5	diversification	diversification	NOUN
gs-4427	230	6	the	the	DET
gs-4427	230	7	current	current	ADJ
gs-4427	230	8	gene	gene	NOUN
gs-4427	230	9	therapy	therapy	NOUN
gs-4427	230	10	landscape	landscape	NOUN
gs-4427	230	11	encompasses	encompass	VERB
gs-4427	230	12	diverse	diverse	ADJ
gs-4427	230	13	technological	technological	ADJ
gs-4427	230	14	platforms	platform	NOUN
gs-4427	230	15	,	,	PUNCT
gs-4427	230	16	each	each	PRON
gs-4427	230	17	with	with	ADP
gs-4427	230	18	distinct	distinct	ADJ
gs-4427	230	19	advantages	advantage	NOUN
gs-4427	230	20	,	,	PUNCT
gs-4427	230	21	limitations	limitation	NOUN
gs-4427	230	22	,	,	PUNCT
gs-4427	230	23	and	and	CCONJ
gs-4427	230	24	optimal	optimal	ADJ
gs-4427	230	25	applications	application	NOUN
gs-4427	230	26	,	,	PUNCT
gs-4427	230	27	reflecting	reflect	VERB
gs-4427	230	28	the	the	DET
gs-4427	230	29	field	field	NOUN
gs-4427	230	30	's	's	PART
gs-4427	230	31	maturation	maturation	NOUN
gs-4427	230	32	beyond	beyond	ADP
gs-4427	230	33	singular	singular	ADJ
gs-4427	230	34	approaches	approach	NOUN
gs-4427	230	35	toward	toward	ADP
gs-4427	230	36	selection	selection	NOUN
gs-4427	230	37	of	of	ADP
gs-4427	230	38	modality	modality	NOUN
gs-4427	230	39	best	well	ADV
gs-4427	230	40	suited	suit	VERB
gs-4427	230	41	to	to	ADP
gs-4427	230	42	specific	specific	ADJ
gs-4427	230	43	therapeutic	therapeutic	ADJ
gs-4427	230	44	objectives	objective	NOUN
gs-4427	230	45	.	.	PUNCT
gs-4427	231	1	viral	viral	ADJ
gs-4427	231	2	vector	vector	NOUN
gs-4427	231	3	-	-	PUNCT
gs-4427	231	4	based	base	VERB
gs-4427	231	5	gene	gene	NOUN
gs-4427	231	6	addition	addition	NOUN
gs-4427	231	7	therapies	therapy	NOUN
gs-4427	231	8	,	,	PUNCT
gs-4427	231	9	particularly	particularly	ADV
gs-4427	231	10	those	those	PRON
gs-4427	231	11	employing	employ	VERB
gs-4427	231	12	aav	aav	NOUN
gs-4427	231	13	vectors	vector	NOUN
gs-4427	231	14	,	,	PUNCT
gs-4427	231	15	have	have	AUX
gs-4427	231	16	established	establish	VERB
gs-4427	231	17	strong	strong	ADJ
gs-4427	231	18	clinical	clinical	ADJ
gs-4427	231	19	track	track	NOUN
gs-4427	231	20	records	record	NOUN
gs-4427	231	21	in	in	ADP
gs-4427	231	22	applications	application	NOUN
gs-4427	231	23	requiring	require	VERB
gs-4427	231	24	sustained	sustained	ADJ
gs-4427	231	25	transgene	transgene	ADJ
gs-4427	231	26	expression	expression	NOUN
gs-4427	231	27	in	in	ADP
gs-4427	231	28	post	post	ADJ
gs-4427	231	29	-	-	ADJ
gs-4427	231	30	mitotic	mitotic	ADJ
gs-4427	231	31	tissues	tissue	NOUN
gs-4427	231	32	including	include	VERB
gs-4427	231	33	liver	liver	NOUN
gs-4427	231	34	,	,	PUNCT
gs-4427	231	35	muscle	muscle	NOUN
gs-4427	231	36	,	,	PUNCT
gs-4427	231	37	retina	retina	NOUN
gs-4427	231	38	,	,	PUNCT
gs-4427	231	39	and	and	CCONJ
gs-4427	231	40	central	central	ADJ
gs-4427	231	41	nervous	nervous	ADJ
gs-4427	231	42	system	system	NOUN
gs-4427	231	43	.	.	PUNCT
gs-4427	232	1	the	the	DET
gs-4427	232	2	demonstration	demonstration	NOUN
gs-4427	232	3	that	that	PRON
gs-4427	232	4	single	single	ADJ
gs-4427	232	5	aav	aav	PROPN
gs-4427	232	6	vector	vector	NOUN
gs-4427	232	7	administration	administration	NOUN
gs-4427	232	8	can	can	AUX
gs-4427	232	9	achieve	achieve	VERB
gs-4427	232	10	multi	multi	ADJ
gs-4427	232	11	-	-	ADJ
gs-4427	232	12	year	year	NOUN
gs-4427	232	13	transgene	transgene	NOUN
gs-4427	232	14	expression	expression	NOUN
gs-4427	232	15	sufficient	sufficient	ADJ
gs-4427	232	16	to	to	PART
gs-4427	232	17	convert	convert	VERB
gs-4427	232	18	severe	severe	ADJ
gs-4427	232	19	hemophilia	hemophilia	NOUN
gs-4427	232	20	to	to	ADP
gs-4427	232	21	mild	mild	ADJ
gs-4427	232	22	phenotype	phenotype	NOUN
gs-4427	232	23	validates	validate	VERB
gs-4427	232	24	this	this	DET
gs-4427	232	25	approach	approach	NOUN
gs-4427	232	26	for	for	ADP
gs-4427	232	27	protein	protein	NOUN
gs-4427	232	28	replacement	replacement	NOUN
gs-4427	232	29	applications	application	NOUN
gs-4427	232	30	where	where	SCONJ
gs-4427	232	31	precise	precise	ADJ
gs-4427	232	32	expression	expression	NOUN
gs-4427	232	33	level	level	NOUN
gs-4427	232	34	control	control	NOUN
gs-4427	232	35	is	be	AUX
gs-4427	232	36	not	not	PART
gs-4427	232	37	critical	critical	ADJ
gs-4427	232	38	and	and	CCONJ
gs-4427	232	39	modest	modest	ADJ
gs-4427	232	40	protein	protein	NOUN
gs-4427	232	41	levels	level	NOUN
gs-4427	232	42	provide	provide	VERB
gs-4427	232	43	substantial	substantial	ADJ
gs-4427	232	44	clinical	clinical	ADJ
gs-4427	232	45	benefit	benefit	NOUN
gs-4427	232	46	.	.	PUNCT
gs-4427	233	1	however	however	ADV
gs-4427	233	2	,	,	PUNCT
gs-4427	233	3	aav	aav	PROPN
gs-4427	233	4	vector	vector	NOUN
gs-4427	233	5	limitations	limitation	NOUN
gs-4427	233	6	including	include	VERB
gs-4427	233	7	packaging	packaging	NOUN
gs-4427	233	8	size	size	NOUN
gs-4427	233	9	constraints	constraint	NOUN
gs-4427	233	10	restricting	restrict	VERB
gs-4427	233	11	transgene	transgene	ADJ
gs-4427	233	12	length	length	NOUN
gs-4427	233	13	to	to	ADP
gs-4427	233	14	approximately	approximately	ADV
gs-4427	233	15	4.7	4.7	NUM
gs-4427	233	16	kilobases	kilobase	NOUN
gs-4427	233	17	,	,	PUNCT
gs-4427	233	18	pre	pre	ADJ
gs-4427	233	19	-	-	ADJ
gs-4427	233	20	existing	exist	VERB
gs-4427	233	21	neutralizing	neutralize	VERB
gs-4427	233	22	antibodies	antibody	NOUN
gs-4427	233	23	limiting	limit	VERB
gs-4427	233	24	eligible	eligible	ADJ
gs-4427	233	25	patient	patient	NOUN
gs-4427	233	26	populations	population	NOUN
gs-4427	233	27	,	,	PUNCT
gs-4427	233	28	and	and	CCONJ
gs-4427	233	29	potential	potential	ADJ
gs-4427	233	30	immunemediated	immunemediate	VERB
gs-4427	233	31	transgene	transgene	ADJ
gs-4427	233	32	expression	expression	NOUN
gs-4427	233	33	loss	loss	NOUN
gs-4427	233	34	highlight	highlight	VERB
gs-4427	233	35	the	the	DET
gs-4427	233	36	need	need	NOUN
gs-4427	233	37	for	for	ADP
gs-4427	233	38	continued	continue	VERB
gs-4427	233	39	platform	platform	NOUN
gs-4427	233	40	refinement	refinement	NOUN
gs-4427	233	41	and	and	CCONJ
gs-4427	233	42	alternative	alternative	ADJ
gs-4427	233	43	approaches	approach	NOUN
gs-4427	233	44	.	.	PUNCT
gs-4427	234	1	crispr	crispr	NOUN
gs-4427	234	2	-	-	PUNCT
gs-4427	234	3	based	base	VERB
gs-4427	234	4	gene	gene	NOUN
gs-4427	234	5	editing	edit	VERB
gs-4427	234	6	offers	offer	VERB
gs-4427	234	7	fundamentally	fundamentally	ADV
gs-4427	234	8	different	different	ADJ
gs-4427	234	9	capabilities	capability	NOUN
gs-4427	234	10	including	include	VERB
gs-4427	234	11	permanent	permanent	ADJ
gs-4427	234	12	correction	correction	NOUN
gs-4427	234	13	of	of	ADP
gs-4427	234	14	pathogenic	pathogenic	ADJ
gs-4427	234	15	mutations	mutation	NOUN
gs-4427	234	16	at	at	ADP
gs-4427	234	17	their	their	PRON
gs-4427	234	18	genomic	genomic	ADJ
gs-4427	234	19	locations	location	NOUN
gs-4427	234	20	,	,	PUNCT
gs-4427	234	21	targeted	target	VERB
gs-4427	234	22	gene	gene	NOUN
gs-4427	234	23	disruption	disruption	NOUN
gs-4427	234	24	for	for	ADP
gs-4427	234	25	loss	loss	NOUN
gs-4427	234	26	-	-	PUNCT
gs-4427	234	27	of	of	ADP
gs-4427	234	28	-	-	PUNCT
gs-4427	234	29	function	function	NOUN
gs-4427	234	30	therapeutic	therapeutic	ADJ
gs-4427	234	31	effects	effect	NOUN
gs-4427	234	32	,	,	PUNCT
gs-4427	234	33	and	and	CCONJ
gs-4427	234	34	precise	precise	ADJ
gs-4427	234	35	insertion	insertion	NOUN
gs-4427	234	36	of	of	ADP
gs-4427	234	37	therapeutic	therapeutic	ADJ
gs-4427	234	38	sequences	sequence	NOUN
gs-4427	234	39	into	into	ADP
gs-4427	234	40	safe	safe	ADJ
gs-4427	234	41	harbor	harbor	NOUN
gs-4427	234	42	loci	locus	NOUN
gs-4427	234	43	enabling	enable	VERB
gs-4427	234	44	sustained	sustained	ADJ
gs-4427	234	45	expression	expression	NOUN
gs-4427	234	46	without	without	ADP
gs-4427	234	47	reliance	reliance	NOUN
gs-4427	234	48	on	on	ADP
gs-4427	234	49	episomal	episomal	ADJ
gs-4427	234	50	vector	vector	NOUN
gs-4427	234	51	persistence	persistence	NOUN
gs-4427	234	52	.	.	PUNCT
gs-4427	235	1	the	the	DET
gs-4427	235	2	approval	approval	NOUN
gs-4427	235	3	of	of	ADP
gs-4427	235	4	casgevy	casgevy	NOUN
gs-4427	235	5	demonstrates	demonstrate	VERB
gs-4427	235	6	clinical	clinical	ADJ
gs-4427	235	7	viability	viability	NOUN
gs-4427	235	8	of	of	ADP
gs-4427	235	9	ex	ex	X
gs-4427	235	10	vivo	vivo	ADJ
gs-4427	235	11	crispr	crispr	ADJ
gs-4427	235	12	editing	editing	NOUN
gs-4427	235	13	,	,	PUNCT
gs-4427	235	14	while	while	SCONJ
gs-4427	235	15	early	early	ADJ
gs-4427	235	16	-	-	PUNCT
gs-4427	235	17	phase	phase	NOUN
gs-4427	235	18	trials	trial	NOUN
gs-4427	235	19	of	of	ADP
gs-4427	235	20	in	in	ADP
gs-4427	235	21	vivo	vivo	NOUN
gs-4427	235	22	editing	editing	NOUN
gs-4427	235	23	delivered	deliver	VERB
gs-4427	235	24	via	via	ADP
gs-4427	235	25	lipid	lipid	ADJ
gs-4427	235	26	nanoparticles	nanoparticle	NOUN
gs-4427	235	27	establish	establish	VERB
gs-4427	235	28	proof	proof	NOUN
gs-4427	235	29	-	-	PUNCT
gs-4427	235	30	ofconcept	ofconcept	ADJ
gs-4427	235	31	for	for	ADP
gs-4427	235	32	direct	direct	ADJ
gs-4427	235	33	tissue	tissue	NOUN
gs-4427	235	34	editing	editing	NOUN
gs-4427	235	35	.	.	PUNCT
gs-4427	236	1	the	the	DET
gs-4427	236	2	development	development	NOUN
gs-4427	236	3	of	of	ADP
gs-4427	236	4	base	base	NOUN
gs-4427	236	5	editors	editor	NOUN
gs-4427	236	6	and	and	CCONJ
gs-4427	236	7	prime	prime	ADJ
gs-4427	236	8	editors	editor	NOUN
gs-4427	236	9	,	,	PUNCT
gs-4427	236	10	enabling	enable	VERB
gs-4427	236	11	nucleotide	nucleotide	NOUN
gs-4427	236	12	-	-	PUNCT
gs-4427	236	13	level	level	NOUN
gs-4427	236	14	changes	change	NOUN
gs-4427	236	15	without	without	ADP
gs-4427	236	16	double	double	ADJ
gs-4427	236	17	-	-	PUNCT
gs-4427	236	18	strand	strand	NOUN
gs-4427	236	19	break	break	NOUN
gs-4427	236	20	formation	formation	NOUN
gs-4427	236	21	,	,	PUNCT
gs-4427	236	22	addresses	address	NOUN
gs-4427	236	23	safety	safety	NOUN
gs-4427	236	24	concerns	concern	NOUN
gs-4427	236	25	regarding	regard	VERB
gs-4427	236	26	unintended	unintended	ADJ
gs-4427	236	27	chromosomal	chromosomal	ADJ
gs-4427	236	28	rearrangements	rearrangement	NOUN
gs-4427	236	29	and	and	CCONJ
gs-4427	236	30	represents	represent	VERB
gs-4427	236	31	the	the	DET
gs-4427	236	32	next	next	ADJ
gs-4427	236	33	generation	generation	NOUN
gs-4427	236	34	of	of	ADP
gs-4427	236	35	editing	edit	VERB
gs-4427	236	36	tools	tool	NOUN
gs-4427	236	37	likely	likely	ADJ
gs-4427	236	38	to	to	PART
gs-4427	236	39	enter	enter	VERB
gs-4427	236	40	clinical	clinical	ADJ
gs-4427	236	41	trials	trial	NOUN
gs-4427	236	42	in	in	ADP
gs-4427	236	43	the	the	DET
gs-4427	236	44	coming	come	VERB
gs-4427	236	45	years	year	NOUN
gs-4427	236	46	.	.	PUNCT
gs-4427	237	1	however	however	ADV
gs-4427	237	2	,	,	PUNCT
gs-4427	237	3	crispr	crispr	ADJ
gs-4427	237	4	technology	technology	NOUN
gs-4427	237	5	faces	face	VERB
gs-4427	237	6	its	its	PRON
gs-4427	237	7	own	own	ADJ
gs-4427	237	8	challenges	challenge	NOUN
gs-4427	237	9	including	include	VERB
gs-4427	237	10	potential	potential	ADJ
gs-4427	237	11	off	off	ADP
gs-4427	237	12	-	-	PUNCT
gs-4427	237	13	target	target	NOUN
gs-4427	237	14	editing	editing	NOUN
gs-4427	237	15	at	at	ADP
gs-4427	237	16	genomic	genomic	ADJ
gs-4427	237	17	sites	site	NOUN
gs-4427	237	18	with	with	ADP
gs-4427	237	19	partial	partial	ADJ
gs-4427	237	20	guide	guide	NOUN
gs-4427	237	21	rna	rna	NOUN
gs-4427	237	22	complementarity	complementarity	NOUN
gs-4427	237	23	,	,	PUNCT
gs-4427	237	24	limited	limited	ADJ
gs-4427	237	25	editing	edit	VERB
gs-4427	237	26	efficiency	efficiency	NOUN
gs-4427	237	27	in	in	ADP
gs-4427	237	28	nongeorgian	nongeorgian	PROPN
gs-4427	237	29	scientists/	scientists/	NUM
gs-4427	237	30	.	.	PUNCT
gs-4427	238	1	7	7	NUM
gs-4427	238	2	n	n	DET
gs-4427	238	3	4	4	NUM
gs-4427	238	4	,	,	PUNCT
gs-4427	238	5	2025	2025	NUM
gs-4427	238	6	645	645	NUM
gs-4427	238	7	dividing	divide	VERB
gs-4427	238	8	cells	cell	NOUN
gs-4427	238	9	for	for	ADP
gs-4427	238	10	some	some	DET
gs-4427	238	11	delivery	delivery	NOUN
gs-4427	238	12	methods	method	NOUN
gs-4427	238	13	,	,	PUNCT
gs-4427	238	14	and	and	CCONJ
gs-4427	238	15	immunogenicity	immunogenicity	NOUN
gs-4427	238	16	of	of	ADP
gs-4427	238	17	cas9	cas9	NOUN
gs-4427	238	18	protein	protein	NOUN
gs-4427	238	19	derived	derive	VERB
gs-4427	238	20	from	from	ADP
gs-4427	238	21	bacterial	bacterial	ADJ
gs-4427	238	22	species	specie	NOUN
gs-4427	238	23	to	to	PART
gs-4427	238	24	which	which	PRON
gs-4427	238	25	humans	human	NOUN
gs-4427	238	26	have	have	VERB
gs-4427	238	27	prior	prior	ADJ
gs-4427	238	28	immune	immune	ADJ
gs-4427	238	29	exposure	exposure	NOUN
gs-4427	238	30	.	.	PUNCT
gs-4427	239	1	car	car	NOUN
gs-4427	239	2	-	-	PUNCT
gs-4427	239	3	t	t	NOUN
gs-4427	239	4	cell	cell	NOUN
gs-4427	239	5	therapy	therapy	NOUN
gs-4427	239	6	represents	represent	VERB
gs-4427	239	7	perhaps	perhaps	ADV
gs-4427	239	8	the	the	DET
gs-4427	239	9	most	most	ADV
gs-4427	239	10	clinically	clinically	ADV
gs-4427	239	11	advanced	advanced	ADJ
gs-4427	239	12	gene	gene	NOUN
gs-4427	239	13	therapy	therapy	NOUN
gs-4427	239	14	modality	modality	NOUN
gs-4427	239	15	,	,	PUNCT
gs-4427	239	16	with	with	ADP
gs-4427	239	17	seven	seven	NUM
gs-4427	239	18	fda	fda	PROPN
gs-4427	239	19	-	-	PUNCT
gs-4427	239	20	approved	approve	VERB
gs-4427	239	21	products	product	NOUN
gs-4427	239	22	and	and	CCONJ
gs-4427	239	23	expanding	expand	VERB
gs-4427	239	24	applications	application	NOUN
gs-4427	239	25	beyond	beyond	ADP
gs-4427	239	26	initial	initial	ADJ
gs-4427	239	27	hematological	hematological	ADJ
gs-4427	239	28	malignancy	malignancy	NOUN
gs-4427	239	29	indications	indication	NOUN
gs-4427	239	30	.	.	PUNCT
gs-4427	240	1	the	the	DET
gs-4427	240	2	dramatic	dramatic	ADJ
gs-4427	240	3	complete	complete	ADJ
gs-4427	240	4	response	response	NOUN
gs-4427	240	5	rates	rate	NOUN
gs-4427	240	6	achieved	achieve	VERB
gs-4427	240	7	in	in	ADP
gs-4427	240	8	relapsed	relapse	VERB
gs-4427	240	9	/	/	SYM
gs-4427	240	10	refractory	refractory	NOUN
gs-4427	240	11	b	b	NOUN
gs-4427	240	12	-	-	PUNCT
gs-4427	240	13	cell	cell	NOUN
gs-4427	240	14	lymphomas	lymphoma	NOUN
gs-4427	240	15	and	and	CCONJ
gs-4427	240	16	acute	acute	ADJ
gs-4427	240	17	lymphoblastic	lymphoblastic	ADJ
gs-4427	240	18	leukemia	leukemia	NOUN
gs-4427	240	19	,	,	PUNCT
gs-4427	240	20	coupled	couple	VERB
gs-4427	240	21	with	with	ADP
gs-4427	240	22	long	long	ADJ
gs-4427	240	23	-	-	PUNCT
gs-4427	240	24	term	term	NOUN
gs-4427	240	25	follow	follow	NOUN
gs-4427	240	26	-	-	PUNCT
gs-4427	240	27	up	up	ADP
gs-4427	240	28	data	datum	NOUN
gs-4427	240	29	demonstrating	demonstrate	VERB
gs-4427	240	30	durable	durable	ADJ
gs-4427	240	31	remissions	remission	NOUN
gs-4427	240	32	in	in	ADP
gs-4427	240	33	substantial	substantial	ADJ
gs-4427	240	34	patient	patient	ADJ
gs-4427	240	35	fractions	fraction	NOUN
gs-4427	240	36	,	,	PUNCT
gs-4427	240	37	establish	establish	VERB
gs-4427	240	38	car	car	NOUN
gs-4427	240	39	-	-	PUNCT
gs-4427	240	40	t	t	NOUN
gs-4427	240	41	therapy	therapy	NOUN
gs-4427	240	42	as	as	ADP
gs-4427	240	43	a	a	DET
gs-4427	240	44	curative	curative	ADJ
gs-4427	240	45	option	option	NOUN
gs-4427	240	46	for	for	ADP
gs-4427	240	47	diseases	disease	NOUN
gs-4427	240	48	previously	previously	ADV
gs-4427	240	49	uniformly	uniformly	ADV
gs-4427	240	50	fatal	fatal	ADJ
gs-4427	240	51	.	.	PUNCT
gs-4427	241	1	the	the	DET
gs-4427	241	2	recent	recent	ADJ
gs-4427	241	3	expansion	expansion	NOUN
gs-4427	241	4	into	into	ADP
gs-4427	241	5	t	t	NOUN
gs-4427	241	6	-	-	PUNCT
gs-4427	241	7	cell	cell	NOUN
gs-4427	241	8	receptor	receptor	NOUN
gs-4427	241	9	therapy	therapy	NOUN
gs-4427	241	10	with	with	ADP
gs-4427	241	11	tecelra	tecelra	NOUN
gs-4427	241	12	's	's	PART
gs-4427	241	13	approval	approval	NOUN
gs-4427	241	14	for	for	ADP
gs-4427	241	15	synovial	synovial	ADJ
gs-4427	241	16	sarcoma	sarcoma	NOUN
gs-4427	241	17	and	and	CCONJ
gs-4427	241	18	tumor	tumor	NOUN
gs-4427	241	19	-	-	PUNCT
gs-4427	241	20	infiltrating	infiltrate	VERB
gs-4427	241	21	lymphocyte	lymphocyte	ADJ
gs-4427	241	22	therapy	therapy	NOUN
gs-4427	241	23	with	with	ADP
gs-4427	241	24	amtagvi	amtagvi	NOUN
gs-4427	241	25	's	's	PART
gs-4427	241	26	approval	approval	NOUN
gs-4427	241	27	for	for	ADP
gs-4427	241	28	melanoma	melanoma	NOUN
gs-4427	241	29	demonstrates	demonstrate	VERB
gs-4427	241	30	continued	continued	ADJ
gs-4427	241	31	innovation	innovation	NOUN
gs-4427	241	32	in	in	ADP
gs-4427	241	33	engineered	engineer	VERB
gs-4427	241	34	cell	cell	NOUN
gs-4427	241	35	therapy	therapy	NOUN
gs-4427	241	36	approaches	approach	VERB
gs-4427	241	37	.	.	PUNCT
gs-4427	242	1	the	the	DET
gs-4427	242	2	preliminary	preliminary	ADJ
gs-4427	242	3	success	success	NOUN
gs-4427	242	4	of	of	ADP
gs-4427	242	5	car	car	NOUN
gs-4427	242	6	-	-	PUNCT
gs-4427	242	7	t	t	NOUN
gs-4427	242	8	therapy	therapy	NOUN
gs-4427	242	9	in	in	ADP
gs-4427	242	10	autoimmune	autoimmune	ADJ
gs-4427	242	11	disorders	disorder	NOUN
gs-4427	242	12	including	include	VERB
gs-4427	242	13	systemic	systemic	ADJ
gs-4427	242	14	lupus	lupus	ADJ
gs-4427	242	15	erythematosus	erythematosus	NOUN
gs-4427	242	16	and	and	CCONJ
gs-4427	242	17	myasthenia	myasthenia	PROPN
gs-4427	242	18	gravis	gravis	NOUN
gs-4427	242	19	suggests	suggest	VERB
gs-4427	242	20	potential	potential	ADJ
gs-4427	242	21	for	for	ADP
gs-4427	242	22	transformative	transformative	ADJ
gs-4427	242	23	impact	impact	NOUN
gs-4427	242	24	beyond	beyond	ADP
gs-4427	242	25	oncology	oncology	NOUN
gs-4427	242	26	,	,	PUNCT
gs-4427	242	27	though	though	SCONJ
gs-4427	242	28	larger	large	ADJ
gs-4427	242	29	controlled	control	VERB
gs-4427	242	30	trials	trial	NOUN
gs-4427	242	31	are	be	AUX
gs-4427	242	32	required	require	VERB
gs-4427	242	33	to	to	PART
gs-4427	242	34	establish	establish	VERB
gs-4427	242	35	optimal	optimal	ADJ
gs-4427	242	36	protocols	protocol	NOUN
gs-4427	242	37	and	and	CCONJ
gs-4427	242	38	define	define	VERB
gs-4427	242	39	patient	patient	ADJ
gs-4427	242	40	populations	population	NOUN
gs-4427	242	41	most	most	ADV
gs-4427	242	42	likely	likely	ADJ
gs-4427	242	43	to	to	PART
gs-4427	242	44	benefit	benefit	VERB
gs-4427	242	45	.	.	PUNCT
gs-4427	243	1	the	the	DET
gs-4427	243	2	integration	integration	NOUN
gs-4427	243	3	of	of	ADP
gs-4427	243	4	multiple	multiple	ADJ
gs-4427	243	5	technological	technological	ADJ
gs-4427	243	6	platforms	platform	NOUN
gs-4427	243	7	within	within	ADP
gs-4427	243	8	comprehensive	comprehensive	ADJ
gs-4427	243	9	therapeutic	therapeutic	ADJ
gs-4427	243	10	strategies	strategy	NOUN
gs-4427	243	11	represents	represent	VERB
gs-4427	243	12	an	an	DET
gs-4427	243	13	emerging	emerge	VERB
gs-4427	243	14	trend	trend	NOUN
gs-4427	243	15	likely	likely	ADJ
gs-4427	243	16	to	to	PART
gs-4427	243	17	accelerate	accelerate	VERB
gs-4427	243	18	as	as	ADP
gs-4427	243	19	the	the	DET
gs-4427	243	20	field	field	NOUN
gs-4427	243	21	matures	mature	NOUN
gs-4427	243	22	.	.	PUNCT
gs-4427	244	1	combination	combination	NOUN
gs-4427	244	2	approaches	approach	NOUN
gs-4427	244	3	might	might	AUX
gs-4427	244	4	include	include	VERB
gs-4427	244	5	aav	aav	NOUN
gs-4427	244	6	-	-	PUNCT
gs-4427	244	7	delivered	deliver	VERB
gs-4427	244	8	base	base	NOUN
gs-4427	244	9	editors	editor	NOUN
gs-4427	244	10	enabling	enable	VERB
gs-4427	244	11	precise	precise	ADJ
gs-4427	244	12	in	in	ADP
gs-4427	244	13	vivo	vivo	NOUN
gs-4427	244	14	editing	edit	VERB
gs-4427	244	15	with	with	ADP
gs-4427	244	16	reduced	reduce	VERB
gs-4427	244	17	immunogenicity	immunogenicity	NOUN
gs-4427	244	18	compared	compare	VERB
gs-4427	244	19	to	to	ADP
gs-4427	244	20	protein	protein	NOUN
gs-4427	244	21	-	-	PUNCT
gs-4427	244	22	based	base	VERB
gs-4427	244	23	editor	editor	NOUN
gs-4427	244	24	delivery	delivery	NOUN
gs-4427	244	25	,	,	PUNCT
gs-4427	244	26	car	car	NOUN
gs-4427	244	27	-	-	PUNCT
gs-4427	244	28	t	t	NOUN
gs-4427	244	29	cells	cell	NOUN
gs-4427	244	30	engineered	engineer	VERB
gs-4427	244	31	with	with	ADP
gs-4427	244	32	crispr	crispr	NOUN
gs-4427	244	33	to	to	PART
gs-4427	244	34	enhance	enhance	VERB
gs-4427	244	35	function	function	NOUN
gs-4427	244	36	or	or	CCONJ
gs-4427	244	37	reduce	reduce	VERB
gs-4427	244	38	exhaustion	exhaustion	NOUN
gs-4427	244	39	,	,	PUNCT
gs-4427	244	40	or	or	CCONJ
gs-4427	244	41	sequential	sequential	ADJ
gs-4427	244	42	administration	administration	NOUN
gs-4427	244	43	of	of	ADP
gs-4427	244	44	different	different	ADJ
gs-4427	244	45	modalities	modality	NOUN
gs-4427	244	46	addressing	address	VERB
gs-4427	244	47	complementary	complementary	ADJ
gs-4427	244	48	aspects	aspect	NOUN
gs-4427	244	49	of	of	ADP
gs-4427	244	50	disease	disease	NOUN
gs-4427	244	51	pathology	pathology	NOUN
gs-4427	244	52	.	.	PUNCT
gs-4427	245	1	the	the	DET
gs-4427	245	2	development	development	NOUN
gs-4427	245	3	of	of	ADP
gs-4427	245	4	switchable	switchable	ADJ
gs-4427	245	5	or	or	CCONJ
gs-4427	245	6	tunable	tunable	ADJ
gs-4427	245	7	gene	gene	NOUN
gs-4427	245	8	expression	expression	NOUN
gs-4427	245	9	systems	system	NOUN
gs-4427	245	10	responsive	responsive	ADJ
gs-4427	245	11	to	to	ADP
gs-4427	245	12	exogenous	exogenous	ADJ
gs-4427	245	13	small	small	ADJ
gs-4427	245	14	molecules	molecule	NOUN
gs-4427	245	15	offers	offer	VERB
gs-4427	245	16	potential	potential	ADJ
gs-4427	245	17	for	for	ADP
gs-4427	245	18	post	post	ADJ
gs-4427	245	19	-	-	ADJ
gs-4427	245	20	administration	administration	ADJ
gs-4427	245	21	control	control	NOUN
gs-4427	245	22	over	over	ADP
gs-4427	245	23	transgene	transgene	ADJ
gs-4427	245	24	activity	activity	NOUN
gs-4427	245	25	,	,	PUNCT
gs-4427	245	26	addressing	address	VERB
gs-4427	245	27	safety	safety	NOUN
gs-4427	245	28	concerns	concern	NOUN
gs-4427	245	29	related	relate	VERB
gs-4427	245	30	to	to	ADP
gs-4427	245	31	excessive	excessive	ADJ
gs-4427	245	32	or	or	CCONJ
gs-4427	245	33	inappropriate	inappropriate	ADJ
gs-4427	245	34	expression	expression	NOUN
gs-4427	245	35	.	.	PUNCT
gs-4427	246	1	these	these	DET
gs-4427	246	2	sophisticated	sophisticated	ADJ
gs-4427	246	3	approaches	approach	NOUN
gs-4427	246	4	leverage	leverage	VERB
gs-4427	246	5	the	the	DET
gs-4427	246	6	strengths	strength	NOUN
gs-4427	246	7	of	of	ADP
gs-4427	246	8	individual	individual	ADJ
gs-4427	246	9	platforms	platform	NOUN
gs-4427	246	10	while	while	SCONJ
gs-4427	246	11	mitigating	mitigate	VERB
gs-4427	246	12	their	their	PRON
gs-4427	246	13	limitations	limitation	NOUN
gs-4427	246	14	,	,	PUNCT
gs-4427	246	15	potentially	potentially	ADV
gs-4427	246	16	achieving	achieve	VERB
gs-4427	246	17	therapeutic	therapeutic	ADJ
gs-4427	246	18	effects	effect	NOUN
gs-4427	246	19	unattainable	unattainable	ADJ
gs-4427	246	20	with	with	ADP
gs-4427	246	21	single	single	ADJ
gs-4427	246	22	-	-	PUNCT
gs-4427	246	23	modality	modality	NOUN
gs-4427	246	24	interventions	intervention	NOUN
gs-4427	246	25	.	.	PUNCT
gs-4427	247	1	manufacturing	manufacture	VERB
gs-4427	247	2	innovation	innovation	NOUN
gs-4427	247	3	as	as	ADP
gs-4427	247	4	critical	critical	ADJ
gs-4427	247	5	enabler	enabler	NOUN
gs-4427	247	6	manufacturing	manufacturing	NOUN
gs-4427	247	7	capability	capability	NOUN
gs-4427	247	8	represents	represent	VERB
gs-4427	247	9	a	a	DET
gs-4427	247	10	critical	critical	ADJ
gs-4427	247	11	determinant	determinant	NOUN
gs-4427	247	12	of	of	ADP
gs-4427	247	13	gene	gene	NOUN
gs-4427	247	14	therapy	therapy	NOUN
gs-4427	247	15	accessibility	accessibility	NOUN
gs-4427	247	16	,	,	PUNCT
gs-4427	247	17	with	with	ADP
gs-4427	247	18	current	current	ADJ
gs-4427	247	19	production	production	NOUN
gs-4427	247	20	limitations	limitation	NOUN
gs-4427	247	21	constraining	constrain	VERB
gs-4427	247	22	the	the	DET
gs-4427	247	23	number	number	NOUN
gs-4427	247	24	of	of	ADP
gs-4427	247	25	patients	patient	NOUN
gs-4427	247	26	who	who	PRON
gs-4427	247	27	can	can	AUX
gs-4427	247	28	receive	receive	VERB
gs-4427	247	29	treatment	treatment	NOUN
gs-4427	247	30	regardless	regardless	ADV
gs-4427	247	31	of	of	ADP
gs-4427	247	32	clinical	clinical	ADJ
gs-4427	247	33	efficacy	efficacy	NOUN
gs-4427	247	34	or	or	CCONJ
gs-4427	247	35	regulatory	regulatory	ADJ
gs-4427	247	36	approval	approval	NOUN
gs-4427	247	37	status	status	NOUN
gs-4427	247	38	.	.	PUNCT
gs-4427	248	1	autologous	autologous	ADJ
gs-4427	248	2	cell	cell	NOUN
gs-4427	248	3	therapies	therapy	NOUN
gs-4427	248	4	face	face	VERB
gs-4427	248	5	particular	particular	ADJ
gs-4427	248	6	challenges	challenge	NOUN
gs-4427	248	7	,	,	PUNCT
gs-4427	248	8	requiring	require	VERB
gs-4427	248	9	individualized	individualized	ADJ
gs-4427	248	10	manufacturing	manufacturing	NOUN
gs-4427	248	11	for	for	ADP
gs-4427	248	12	each	each	DET
gs-4427	248	13	patient	patient	NOUN
gs-4427	248	14	with	with	ADP
gs-4427	248	15	timelines	timeline	NOUN
gs-4427	248	16	typically	typically	ADV
gs-4427	248	17	spanning	span	VERB
gs-4427	248	18	2	2	NUM
gs-4427	248	19	-	-	SYM
gs-4427	248	20	4	4	NUM
gs-4427	248	21	weeks	week	NOUN
gs-4427	248	22	from	from	ADP
gs-4427	248	23	cell	cell	NOUN
gs-4427	248	24	collection	collection	NOUN
gs-4427	248	25	to	to	ADP
gs-4427	248	26	product	product	NOUN
gs-4427	248	27	delivery	delivery	NOUN
gs-4427	248	28	(	(	PUNCT
gs-4427	248	29	lu	lu	PROPN
gs-4427	248	30	and	and	CCONJ
gs-4427	248	31	jiang	jiang	PROPN
gs-4427	248	32	,	,	PUNCT
gs-4427	248	33	2022	2022	NUM
gs-4427	248	34	)	)	PUNCT
gs-4427	248	35	.	.	PUNCT
gs-4427	249	1	the	the	DET
gs-4427	249	2	complex	complex	ADJ
gs-4427	249	3	multi	multi	ADJ
gs-4427	249	4	-	-	ADJ
gs-4427	249	5	step	step	ADJ
gs-4427	249	6	process	process	NOUN
gs-4427	249	7	including	include	VERB
gs-4427	249	8	cell	cell	NOUN
gs-4427	249	9	activation	activation	NOUN
gs-4427	249	10	,	,	PUNCT
gs-4427	249	11	viral	viral	ADJ
gs-4427	249	12	transduction	transduction	NOUN
gs-4427	249	13	,	,	PUNCT
gs-4427	249	14	culture	culture	NOUN
gs-4427	249	15	expansion	expansion	NOUN
gs-4427	249	16	,	,	PUNCT
gs-4427	249	17	quality	quality	NOUN
gs-4427	249	18	control	control	NOUN
gs-4427	249	19	testing	testing	NOUN
gs-4427	249	20	,	,	PUNCT
gs-4427	249	21	formulation	formulation	NOUN
gs-4427	249	22	,	,	PUNCT
gs-4427	249	23	and	and	CCONJ
gs-4427	249	24	cryopreservation	cryopreservation	NOUN
gs-4427	249	25	demands	demand	VERB
gs-4427	249	26	specialized	specialized	ADJ
gs-4427	249	27	facilities	facility	NOUN
gs-4427	249	28	,	,	PUNCT
gs-4427	249	29	highly	highly	ADV
gs-4427	249	30	trained	train	VERB
gs-4427	249	31	personnel	personnel	NOUN
gs-4427	249	32	,	,	PUNCT
gs-4427	249	33	and	and	CCONJ
gs-4427	249	34	sophisticated	sophisticated	ADJ
gs-4427	249	35	quality	quality	NOUN
gs-4427	249	36	systems	system	NOUN
gs-4427	249	37	ensuring	ensure	VERB
gs-4427	249	38	product	product	NOUN
gs-4427	249	39	consistency	consistency	NOUN
gs-4427	249	40	and	and	CCONJ
gs-4427	249	41	safety	safety	NOUN
gs-4427	249	42	.	.	PUNCT
gs-4427	250	1	manufacturing	manufacture	VERB
gs-4427	250	2	failures	failure	NOUN
gs-4427	250	3	,	,	PUNCT
gs-4427	250	4	occurring	occur	VERB
gs-4427	250	5	in	in	ADP
gs-4427	250	6	2	2	NUM
gs-4427	250	7	-	-	SYM
gs-4427	250	8	10	10	NUM
gs-4427	250	9	%	%	NOUN
gs-4427	250	10	of	of	ADP
gs-4427	250	11	cases	case	NOUN
gs-4427	250	12	due	due	ADJ
gs-4427	250	13	to	to	ADP
gs-4427	250	14	inadequate	inadequate	ADJ
gs-4427	250	15	cell	cell	NOUN
gs-4427	250	16	collection	collection	NOUN
gs-4427	250	17	,	,	PUNCT
gs-4427	250	18	failed	fail	VERB
gs-4427	250	19	transduction	transduction	NOUN
gs-4427	250	20	,	,	PUNCT
gs-4427	250	21	contamination	contamination	NOUN
gs-4427	250	22	,	,	PUNCT
gs-4427	250	23	or	or	CCONJ
gs-4427	250	24	cells	cell	NOUN
gs-4427	250	25	not	not	PART
gs-4427	250	26	georgian	georgian	NOUN
gs-4427	250	27	scientists/	scientists/	NUM
gs-4427	250	28	.	.	PUNCT
gs-4427	251	1	7	7	NUM
gs-4427	251	2	n	n	DET
gs-4427	251	3	4	4	NUM
gs-4427	251	4	,	,	PUNCT
gs-4427	251	5	2025	2025	NUM
gs-4427	251	6	646	646	NUM
gs-4427	251	7	meeting	meeting	NOUN
gs-4427	251	8	release	release	NOUN
gs-4427	251	9	specifications	specification	NOUN
gs-4427	251	10	,	,	PUNCT
gs-4427	251	11	necessitate	necessitate	ADJ
gs-4427	251	12	process	process	NOUN
gs-4427	251	13	restarts	restart	NOUN
gs-4427	251	14	and	and	CCONJ
gs-4427	251	15	impose	impose	VERB
gs-4427	251	16	substantial	substantial	ADJ
gs-4427	251	17	delays	delay	NOUN
gs-4427	251	18	for	for	ADP
gs-4427	251	19	patients	patient	NOUN
gs-4427	251	20	with	with	ADP
gs-4427	251	21	aggressive	aggressive	ADJ
gs-4427	251	22	diseases	disease	NOUN
gs-4427	251	23	.	.	PUNCT
gs-4427	252	1	the	the	DET
gs-4427	252	2	current	current	ADJ
gs-4427	252	3	centralized	centralized	ADJ
gs-4427	252	4	manufacturing	manufacturing	NOUN
gs-4427	252	5	model	model	NOUN
gs-4427	252	6	,	,	PUNCT
gs-4427	252	7	with	with	ADP
gs-4427	252	8	most	most	ADJ
gs-4427	252	9	production	production	NOUN
gs-4427	252	10	concentrated	concentrate	VERB
gs-4427	252	11	at	at	ADP
gs-4427	252	12	limited	limited	ADJ
gs-4427	252	13	numbers	number	NOUN
gs-4427	252	14	of	of	ADP
gs-4427	252	15	specialized	specialized	ADJ
gs-4427	252	16	contract	contract	NOUN
gs-4427	252	17	manufacturing	manufacturing	NOUN
gs-4427	252	18	organizations	organization	NOUN
gs-4427	252	19	,	,	PUNCT
gs-4427	252	20	creates	create	VERB
gs-4427	252	21	capacity	capacity	NOUN
gs-4427	252	22	bottlenecks	bottleneck	NOUN
gs-4427	252	23	and	and	CCONJ
gs-4427	252	24	logistical	logistical	ADJ
gs-4427	252	25	complexity	complexity	NOUN
gs-4427	252	26	coordinating	coordinate	VERB
gs-4427	252	27	patient	patient	ADJ
gs-4427	252	28	material	material	NOUN
gs-4427	252	29	shipment	shipment	NOUN
gs-4427	252	30	,	,	PUNCT
gs-4427	252	31	production	production	NOUN
gs-4427	252	32	scheduling	scheduling	NOUN
gs-4427	252	33	,	,	PUNCT
gs-4427	252	34	and	and	CCONJ
gs-4427	252	35	finished	finish	VERB
gs-4427	252	36	product	product	NOUN
gs-4427	252	37	delivery	delivery	NOUN
gs-4427	252	38	.	.	PUNCT
gs-4427	253	1	several	several	ADJ
gs-4427	253	2	innovative	innovative	ADJ
gs-4427	253	3	approaches	approach	NOUN
gs-4427	253	4	aim	aim	VERB
gs-4427	253	5	to	to	PART
gs-4427	253	6	address	address	VERB
gs-4427	253	7	manufacturing	manufacturing	NOUN
gs-4427	253	8	limitations	limitation	NOUN
gs-4427	253	9	and	and	CCONJ
gs-4427	253	10	enhance	enhance	VERB
gs-4427	253	11	scalability	scalability	NOUN
gs-4427	253	12	.	.	PUNCT
gs-4427	254	1	closed	close	VERB
gs-4427	254	2	automated	automate	VERB
gs-4427	254	3	manufacturing	manufacturing	NOUN
gs-4427	254	4	systems	system	NOUN
gs-4427	254	5	reduce	reduce	VERB
gs-4427	254	6	hands	hand	NOUN
gs-4427	254	7	-	-	PUNCT
gs-4427	254	8	on	on	ADP
gs-4427	254	9	manipulation	manipulation	NOUN
gs-4427	254	10	requirements	requirement	NOUN
gs-4427	254	11	,	,	PUNCT
gs-4427	254	12	minimize	minimize	VERB
gs-4427	254	13	contamination	contamination	NOUN
gs-4427	254	14	risks	risk	NOUN
gs-4427	254	15	,	,	PUNCT
gs-4427	254	16	improve	improve	VERB
gs-4427	254	17	process	process	NOUN
gs-4427	254	18	consistency	consistency	NOUN
gs-4427	254	19	,	,	PUNCT
gs-4427	254	20	and	and	CCONJ
gs-4427	254	21	potentially	potentially	ADV
gs-4427	254	22	enable	enable	ADJ
gs-4427	254	23	distributed	distribute	VERB
gs-4427	254	24	manufacturing	manufacturing	NOUN
gs-4427	254	25	at	at	ADP
gs-4427	254	26	treatment	treatment	NOUN
gs-4427	254	27	centers	center	NOUN
gs-4427	254	28	rather	rather	ADV
gs-4427	254	29	than	than	ADP
gs-4427	254	30	centralized	centralized	ADJ
gs-4427	254	31	facilities	facility	NOUN
gs-4427	254	32	.	.	PUNCT
gs-4427	255	1	the	the	DET
gs-4427	255	2	cocoon	cocoon	NOUN
gs-4427	255	3	and	and	CCONJ
gs-4427	255	4	xuri	xuri	PROPN
gs-4427	255	5	platforms	platform	NOUN
gs-4427	255	6	represent	represent	VERB
gs-4427	255	7	examples	example	NOUN
gs-4427	255	8	of	of	ADP
gs-4427	255	9	closed	closed	ADJ
gs-4427	255	10	automated	automate	VERB
gs-4427	255	11	systems	system	NOUN
gs-4427	255	12	under	under	ADP
gs-4427	255	13	development	development	NOUN
gs-4427	255	14	or	or	CCONJ
gs-4427	255	15	in	in	ADP
gs-4427	255	16	use	use	NOUN
gs-4427	255	17	for	for	ADP
gs-4427	255	18	car	car	NOUN
gs-4427	255	19	-	-	PUNCT
gs-4427	255	20	t	t	NOUN
gs-4427	255	21	manufacturing	manufacturing	NOUN
gs-4427	255	22	,	,	PUNCT
gs-4427	255	23	potentially	potentially	ADV
gs-4427	255	24	enabling	enable	VERB
gs-4427	255	25	point	point	NOUN
gs-4427	255	26	-	-	PUNCT
gs-4427	255	27	of	of	ADP
gs-4427	255	28	-	-	PUNCT
gs-4427	255	29	care	care	NOUN
gs-4427	255	30	production	production	NOUN
gs-4427	255	31	reducing	reduce	VERB
gs-4427	255	32	logistics	logistic	NOUN
gs-4427	255	33	complexity	complexity	NOUN
gs-4427	255	34	and	and	CCONJ
gs-4427	255	35	treatment	treatment	NOUN
gs-4427	255	36	timelines	timeline	NOUN
gs-4427	255	37	.	.	PUNCT
gs-4427	256	1	allogeneic	allogeneic	VERB
gs-4427	256	2	off	off	ADP
gs-4427	256	3	-	-	PUNCT
gs-4427	256	4	the	the	DET
gs-4427	256	5	-	-	PUNCT
gs-4427	256	6	shelf	shelf	NOUN
gs-4427	256	7	cell	cell	NOUN
gs-4427	256	8	therapy	therapy	NOUN
gs-4427	256	9	products	product	NOUN
gs-4427	256	10	manufactured	manufacture	VERB
gs-4427	256	11	from	from	ADP
gs-4427	256	12	healthy	healthy	ADJ
gs-4427	256	13	donor	donor	NOUN
gs-4427	256	14	cells	cell	NOUN
gs-4427	256	15	in	in	ADP
gs-4427	256	16	large	large	ADJ
gs-4427	256	17	batches	batch	NOUN
gs-4427	256	18	,	,	PUNCT
gs-4427	256	19	then	then	ADV
gs-4427	256	20	cryopreserved	cryopreserve	VERB
gs-4427	256	21	for	for	ADP
gs-4427	256	22	on	on	ADP
gs-4427	256	23	-	-	PUNCT
gs-4427	256	24	demand	demand	NOUN
gs-4427	256	25	availability	availability	NOUN
gs-4427	256	26	,	,	PUNCT
gs-4427	256	27	eliminate	eliminate	VERB
gs-4427	256	28	patient	patient	NOUN
gs-4427	256	29	-	-	PUNCT
gs-4427	256	30	specific	specific	ADJ
gs-4427	256	31	manufacturing	manufacturing	NOUN
gs-4427	256	32	requirements	requirement	NOUN
gs-4427	256	33	and	and	CCONJ
gs-4427	256	34	associated	associated	ADJ
gs-4427	256	35	delays	delay	NOUN
gs-4427	256	36	,	,	PUNCT
gs-4427	256	37	though	though	SCONJ
gs-4427	256	38	they	they	PRON
gs-4427	256	39	require	require	VERB
gs-4427	256	40	strategies	strategy	NOUN
gs-4427	256	41	addressing	address	VERB
gs-4427	256	42	immune	immune	ADJ
gs-4427	256	43	rejection	rejection	NOUN
gs-4427	256	44	including	include	VERB
gs-4427	256	45	hla	hla	PROPN
gs-4427	256	46	matching	matching	NOUN
gs-4427	256	47	or	or	CCONJ
gs-4427	256	48	engineering	engineering	NOUN
gs-4427	256	49	of	of	ADP
gs-4427	256	50	universal	universal	ADJ
gs-4427	256	51	donor	donor	NOUN
gs-4427	256	52	cells	cell	NOUN
gs-4427	256	53	through	through	ADP
gs-4427	256	54	crisprmediated	crisprmediate	VERB
gs-4427	256	55	disruption	disruption	NOUN
gs-4427	256	56	of	of	ADP
gs-4427	256	57	hla	hla	NOUN
gs-4427	256	58	genes	gene	NOUN
gs-4427	256	59	and	and	CCONJ
gs-4427	256	60	other	other	ADJ
gs-4427	256	61	immunogenicity	immunogenicity	NOUN
gs-4427	256	62	determinants	determinant	NOUN
gs-4427	256	63	.	.	PUNCT
gs-4427	257	1	early	early	ADJ
gs-4427	257	2	clinical	clinical	ADJ
gs-4427	257	3	trials	trial	NOUN
gs-4427	257	4	of	of	ADP
gs-4427	257	5	allogeneic	allogeneic	ADJ
gs-4427	257	6	car	car	NOUN
gs-4427	257	7	-	-	PUNCT
gs-4427	257	8	t	t	NOUN
gs-4427	257	9	products	product	NOUN
gs-4427	257	10	demonstrate	demonstrate	VERB
gs-4427	257	11	proof	proof	NOUN
gs-4427	257	12	-	-	PUNCT
gs-4427	257	13	of	of	ADP
gs-4427	257	14	-	-	PUNCT
gs-4427	257	15	concept	concept	NOUN
gs-4427	257	16	feasibility	feasibility	NOUN
gs-4427	257	17	,	,	PUNCT
gs-4427	257	18	though	though	SCONJ
gs-4427	257	19	persistence	persistence	NOUN
gs-4427	257	20	and	and	CCONJ
gs-4427	257	21	efficacy	efficacy	NOUN
gs-4427	257	22	appear	appear	VERB
gs-4427	257	23	reduced	reduce	VERB
gs-4427	257	24	compared	compare	VERB
gs-4427	257	25	to	to	ADP
gs-4427	257	26	autologous	autologous	ADJ
gs-4427	257	27	products	product	NOUN
gs-4427	257	28	,	,	PUNCT
gs-4427	257	29	motivating	motivate	VERB
gs-4427	257	30	continued	continue	VERB
gs-4427	257	31	optimization	optimization	NOUN
gs-4427	257	32	.	.	PUNCT
gs-4427	258	1	for	for	ADP
gs-4427	258	2	viral	viral	ADJ
gs-4427	258	3	vector	vector	NOUN
gs-4427	258	4	-	-	PUNCT
gs-4427	258	5	based	base	VERB
gs-4427	258	6	therapies	therapy	NOUN
gs-4427	258	7	,	,	PUNCT
gs-4427	258	8	manufacturing	manufacturing	NOUN
gs-4427	258	9	scale	scale	NOUN
gs-4427	258	10	-	-	PUNCT
gs-4427	258	11	up	up	NOUN
gs-4427	258	12	to	to	PART
gs-4427	258	13	meet	meet	VERB
gs-4427	258	14	potential	potential	ADJ
gs-4427	258	15	demand	demand	NOUN
gs-4427	258	16	for	for	ADP
gs-4427	258	17	common	common	ADJ
gs-4427	258	18	disease	disease	NOUN
gs-4427	258	19	applications	application	NOUN
gs-4427	258	20	presents	present	VERB
gs-4427	258	21	different	different	ADJ
gs-4427	258	22	challenges	challenge	NOUN
gs-4427	258	23	.	.	PUNCT
gs-4427	259	1	current	current	ADJ
gs-4427	259	2	aav	aav	PROPN
gs-4427	259	3	production	production	NOUN
gs-4427	259	4	predominantly	predominantly	ADV
gs-4427	259	5	employs	employ	VERB
gs-4427	259	6	transient	transient	ADJ
gs-4427	259	7	transfection	transfection	NOUN
gs-4427	259	8	of	of	ADP
gs-4427	259	9	adherent	adherent	ADJ
gs-4427	259	10	hek293	hek293	PROPN
gs-4427	259	11	cells	cell	NOUN
gs-4427	259	12	,	,	PUNCT
gs-4427	259	13	a	a	DET
gs-4427	259	14	process	process	NOUN
gs-4427	259	15	suitable	suitable	ADJ
gs-4427	259	16	for	for	ADP
gs-4427	259	17	small	small	ADJ
gs-4427	259	18	to	to	PART
gs-4427	259	19	moderate	moderate	ADJ
gs-4427	259	20	production	production	NOUN
gs-4427	259	21	volumes	volume	NOUN
gs-4427	259	22	but	but	CCONJ
gs-4427	259	23	challenging	challenge	VERB
gs-4427	259	24	to	to	PART
gs-4427	259	25	scale	scale	VERB
gs-4427	259	26	to	to	ADP
gs-4427	259	27	the	the	DET
gs-4427	259	28	levels	level	NOUN
gs-4427	259	29	required	require	VERB
gs-4427	259	30	for	for	ADP
gs-4427	259	31	treating	treat	VERB
gs-4427	259	32	large	large	ADJ
gs-4427	259	33	patient	patient	ADJ
gs-4427	259	34	populations	population	NOUN
gs-4427	259	35	.	.	PUNCT
gs-4427	260	1	the	the	DET
gs-4427	260	2	transition	transition	NOUN
gs-4427	260	3	to	to	ADP
gs-4427	260	4	suspension	suspension	NOUN
gs-4427	260	5	-	-	PUNCT
gs-4427	260	6	adapted	adapt	VERB
gs-4427	260	7	cell	cell	NOUN
gs-4427	260	8	lines	line	NOUN
gs-4427	260	9	enables	enable	VERB
gs-4427	260	10	bioreactor	bioreactor	NOUN
gs-4427	260	11	-	-	PUNCT
gs-4427	260	12	based	base	VERB
gs-4427	260	13	production	production	NOUN
gs-4427	260	14	with	with	ADP
gs-4427	260	15	substantially	substantially	ADV
gs-4427	260	16	increased	increase	VERB
gs-4427	260	17	volumetric	volumetric	NOUN
gs-4427	260	18	yields	yield	NOUN
gs-4427	260	19	and	and	CCONJ
gs-4427	260	20	improved	improved	ADJ
gs-4427	260	21	scalability	scalability	NOUN
gs-4427	260	22	.	.	PUNCT
gs-4427	261	1	alternative	alternative	ADJ
gs-4427	261	2	production	production	NOUN
gs-4427	261	3	platforms	platform	NOUN
gs-4427	261	4	including	include	VERB
gs-4427	261	5	baculovirus	baculovirus	NOUN
gs-4427	261	6	-	-	PUNCT
gs-4427	261	7	insect	insect	NOUN
gs-4427	261	8	cell	cell	NOUN
gs-4427	261	9	systems	system	NOUN
gs-4427	261	10	and	and	CCONJ
gs-4427	261	11	herpes	herpe	NOUN
gs-4427	261	12	simplex	simplex	NOUN
gs-4427	261	13	virus	virus	NOUN
gs-4427	261	14	complementation	complementation	NOUN
gs-4427	261	15	systems	system	NOUN
gs-4427	261	16	offer	offer	VERB
gs-4427	261	17	different	different	ADJ
gs-4427	261	18	advantages	advantage	NOUN
gs-4427	261	19	regarding	regard	VERB
gs-4427	261	20	yield	yield	NOUN
gs-4427	261	21	,	,	PUNCT
gs-4427	261	22	purity	purity	NOUN
gs-4427	261	23	,	,	PUNCT
gs-4427	261	24	and	and	CCONJ
gs-4427	261	25	manufacturing	manufacturing	NOUN
gs-4427	261	26	complexity	complexity	NOUN
gs-4427	261	27	.	.	PUNCT
gs-4427	262	1	downstream	downstream	ADJ
gs-4427	262	2	purification	purification	NOUN
gs-4427	262	3	processes	process	NOUN
gs-4427	262	4	removing	remove	VERB
gs-4427	262	5	empty	empty	ADJ
gs-4427	262	6	capsids	capsid	NOUN
gs-4427	262	7	,	,	PUNCT
gs-4427	262	8	host	host	NOUN
gs-4427	262	9	cell	cell	NOUN
gs-4427	262	10	proteins	protein	NOUN
gs-4427	262	11	,	,	PUNCT
gs-4427	262	12	and	and	CCONJ
gs-4427	262	13	residual	residual	ADJ
gs-4427	262	14	dna	dna	PROPN
gs-4427	262	15	represent	represent	VERB
gs-4427	262	16	another	another	DET
gs-4427	262	17	critical	critical	ADJ
gs-4427	262	18	aspect	aspect	NOUN
gs-4427	262	19	requiring	require	VERB
gs-4427	262	20	optimization	optimization	NOUN
gs-4427	262	21	to	to	PART
gs-4427	262	22	achieve	achieve	VERB
gs-4427	262	23	the	the	DET
gs-4427	262	24	purity	purity	NOUN
gs-4427	262	25	levels	level	NOUN
gs-4427	262	26	necessary	necessary	ADJ
gs-4427	262	27	for	for	ADP
gs-4427	262	28	large	large	ADJ
gs-4427	262	29	-	-	PUNCT
gs-4427	262	30	dose	dose	NOUN
gs-4427	262	31	systemic	systemic	ADJ
gs-4427	262	32	administration	administration	NOUN
gs-4427	262	33	.	.	PUNCT
gs-4427	263	1	the	the	DET
gs-4427	263	2	substantial	substantial	ADJ
gs-4427	263	3	costs	cost	NOUN
gs-4427	263	4	associated	associate	VERB
gs-4427	263	5	with	with	ADP
gs-4427	263	6	viral	viral	ADJ
gs-4427	263	7	vector	vector	NOUN
gs-4427	263	8	manufacturing	manufacturing	NOUN
gs-4427	263	9	,	,	PUNCT
gs-4427	263	10	ranging	range	VERB
gs-4427	263	11	from	from	ADP
gs-4427	263	12	hundreds	hundred	NOUN
gs-4427	263	13	of	of	ADP
gs-4427	263	14	thousands	thousand	NOUN
gs-4427	263	15	to	to	PART
gs-4427	263	16	millions	million	NOUN
gs-4427	263	17	of	of	ADP
gs-4427	263	18	dollars	dollar	NOUN
gs-4427	263	19	per	per	ADP
gs-4427	263	20	patient	patient	NOUN
gs-4427	263	21	dose	dose	NOUN
gs-4427	263	22	depending	depend	VERB
gs-4427	263	23	on	on	ADP
gs-4427	263	24	vector	vector	NOUN
gs-4427	263	25	dose	dose	NOUN
gs-4427	263	26	and	and	CCONJ
gs-4427	263	27	production	production	NOUN
gs-4427	263	28	scale	scale	NOUN
gs-4427	263	29	,	,	PUNCT
gs-4427	263	30	contribute	contribute	VERB
gs-4427	263	31	significantly	significantly	ADV
gs-4427	263	32	to	to	ADP
gs-4427	263	33	overall	overall	ADJ
gs-4427	263	34	gene	gene	NOUN
gs-4427	263	35	therapy	therapy	NOUN
gs-4427	263	36	pricing	pricing	NOUN
gs-4427	263	37	and	and	CCONJ
gs-4427	263	38	represent	represent	VERB
gs-4427	263	39	a	a	DET
gs-4427	263	40	key	key	ADJ
gs-4427	263	41	target	target	NOUN
gs-4427	263	42	for	for	ADP
gs-4427	263	43	cost	cost	NOUN
gs-4427	263	44	reduction	reduction	NOUN
gs-4427	263	45	efforts	effort	NOUN
gs-4427	263	46	.	.	PUNCT
gs-4427	264	1	quality	quality	NOUN
gs-4427	264	2	control	control	NOUN
gs-4427	264	3	and	and	CCONJ
gs-4427	264	4	characterization	characterization	NOUN
gs-4427	264	5	of	of	ADP
gs-4427	264	6	gene	gene	NOUN
gs-4427	264	7	therapy	therapy	NOUN
gs-4427	264	8	products	product	NOUN
gs-4427	264	9	present	present	VERB
gs-4427	264	10	unique	unique	ADJ
gs-4427	264	11	challenges	challenge	NOUN
gs-4427	264	12	compared	compare	VERB
gs-4427	264	13	to	to	ADP
gs-4427	264	14	conventional	conventional	ADJ
gs-4427	264	15	pharmaceuticals	pharmaceutical	NOUN
gs-4427	264	16	due	due	ADP
gs-4427	264	17	to	to	ADP
gs-4427	264	18	biological	biological	ADJ
gs-4427	264	19	complexity	complexity	NOUN
gs-4427	264	20	and	and	CCONJ
gs-4427	264	21	product	product	NOUN
gs-4427	264	22	heterogeneity	heterogeneity	NOUN
gs-4427	264	23	.	.	PUNCT
gs-4427	265	1	car	car	NOUN
gs-4427	265	2	-	-	PUNCT
gs-4427	265	3	t	t	NOUN
gs-4427	265	4	products	product	NOUN
gs-4427	265	5	comprise	comprise	VERB
gs-4427	265	6	mixed	mixed	ADJ
gs-4427	265	7	cell	cell	NOUN
gs-4427	265	8	populations	population	NOUN
gs-4427	265	9	with	with	ADP
gs-4427	265	10	varying	vary	VERB
gs-4427	265	11	phenotypes	phenotype	NOUN
gs-4427	265	12	,	,	PUNCT
gs-4427	265	13	transduction	transduction	NOUN
gs-4427	265	14	efficiencies	efficiency	NOUN
gs-4427	265	15	,	,	PUNCT
gs-4427	265	16	and	and	CCONJ
gs-4427	265	17	functional	functional	ADJ
gs-4427	265	18	capabilities	capability	NOUN
gs-4427	265	19	requiring	require	VERB
gs-4427	265	20	multiple	multiple	ADJ
gs-4427	265	21	orthogonal	orthogonal	ADJ
gs-4427	265	22	assays	assay	NOUN
gs-4427	265	23	to	to	PART
gs-4427	265	24	adequately	adequately	ADV
gs-4427	265	25	characterize	characterize	VERB
gs-4427	265	26	identity	identity	NOUN
gs-4427	265	27	,	,	PUNCT
gs-4427	265	28	purity	purity	NOUN
gs-4427	265	29	,	,	PUNCT
gs-4427	265	30	potency	potency	NOUN
gs-4427	265	31	,	,	PUNCT
gs-4427	265	32	and	and	CCONJ
gs-4427	265	33	safety	safety	NOUN
gs-4427	265	34	.	.	PUNCT
gs-4427	266	1	vector	vector	NOUN
gs-4427	266	2	preparations	preparation	NOUN
gs-4427	266	3	require	require	VERB
gs-4427	266	4	georgian	georgian	PROPN
gs-4427	266	5	scientists/	scientists/	NUM
gs-4427	266	6	.	.	PUNCT
gs-4427	267	1	7	7	NUM
gs-4427	267	2	n	n	DET
gs-4427	267	3	4	4	NUM
gs-4427	267	4	,	,	PUNCT
gs-4427	267	5	2025	2025	NUM
gs-4427	267	6	647	647	NUM
gs-4427	267	7	assessment	assessment	NOUN
gs-4427	267	8	of	of	ADP
gs-4427	267	9	physical	physical	ADJ
gs-4427	267	10	titer	titer	NOUN
gs-4427	267	11	,	,	PUNCT
gs-4427	267	12	infectious	infectious	ADJ
gs-4427	267	13	titer	titer	NOUN
gs-4427	267	14	,	,	PUNCT
gs-4427	267	15	and	and	CCONJ
gs-4427	267	16	empty	empty	ADJ
gs-4427	267	17	versus	versus	ADP
gs-4427	267	18	full	full	ADJ
gs-4427	267	19	capsid	capsid	ADJ
gs-4427	267	20	ratios	ratio	NOUN
gs-4427	267	21	,	,	PUNCT
gs-4427	267	22	residual	residual	ADJ
gs-4427	267	23	impurities	impurity	NOUN
gs-4427	267	24	,	,	PUNCT
gs-4427	267	25	and	and	CCONJ
gs-4427	267	26	adventitious	adventitious	ADJ
gs-4427	267	27	agent	agent	NOUN
gs-4427	267	28	testing	testing	NOUN
gs-4427	267	29	.	.	PUNCT
gs-4427	268	1	the	the	DET
gs-4427	268	2	development	development	NOUN
gs-4427	268	3	of	of	ADP
gs-4427	268	4	rapid	rapid	ADJ
gs-4427	268	5	,	,	PUNCT
gs-4427	268	6	cost	cost	NOUN
gs-4427	268	7	-	-	PUNCT
gs-4427	268	8	effective	effective	ADJ
gs-4427	268	9	analytical	analytical	ADJ
gs-4427	268	10	methods	method	NOUN
gs-4427	268	11	enabling	enable	VERB
gs-4427	268	12	real	real	ADJ
gs-4427	268	13	-	-	PUNCT
gs-4427	268	14	time	time	NOUN
gs-4427	268	15	release	release	NOUN
gs-4427	268	16	testing	testing	NOUN
gs-4427	268	17	rather	rather	ADV
gs-4427	268	18	than	than	ADP
gs-4427	268	19	extended	extend	VERB
gs-4427	268	20	hold	hold	NOUN
gs-4427	268	21	times	time	NOUN
gs-4427	268	22	awaiting	await	VERB
gs-4427	268	23	assay	assay	NOUN
gs-4427	268	24	results	result	NOUN
gs-4427	268	25	could	could	AUX
gs-4427	268	26	substantially	substantially	ADV
gs-4427	268	27	reduce	reduce	VERB
gs-4427	268	28	treatment	treatment	NOUN
gs-4427	268	29	timelines	timeline	NOUN
gs-4427	268	30	.	.	PUNCT
gs-4427	269	1	standardization	standardization	NOUN
gs-4427	269	2	of	of	ADP
gs-4427	269	3	potency	potency	NOUN
gs-4427	269	4	assays	assay	VERB
gs-4427	269	5	across	across	ADP
gs-4427	269	6	different	different	ADJ
gs-4427	269	7	products	product	NOUN
gs-4427	269	8	and	and	CCONJ
gs-4427	269	9	manufacturing	manufacturing	NOUN
gs-4427	269	10	sites	site	NOUN
gs-4427	269	11	remains	remain	VERB
gs-4427	269	12	an	an	DET
gs-4427	269	13	ongoing	ongoing	ADJ
gs-4427	269	14	challenge	challenge	NOUN
gs-4427	269	15	,	,	PUNCT
gs-4427	269	16	as	as	SCONJ
gs-4427	269	17	functional	functional	ADJ
gs-4427	269	18	assessments	assessment	NOUN
gs-4427	269	19	often	often	ADV
gs-4427	269	20	demonstrate	demonstrate	VERB
gs-4427	269	21	high	high	ADJ
gs-4427	269	22	variability	variability	NOUN
gs-4427	269	23	and	and	CCONJ
gs-4427	269	24	limited	limited	ADJ
gs-4427	269	25	correlation	correlation	NOUN
gs-4427	269	26	with	with	ADP
gs-4427	269	27	clinical	clinical	ADJ
gs-4427	269	28	outcomes	outcome	NOUN
gs-4427	269	29	,	,	PUNCT
gs-4427	269	30	necessitating	necessitate	VERB
gs-4427	269	31	continued	continue	VERB
gs-4427	269	32	refinement	refinement	NOUN
gs-4427	269	33	and	and	CCONJ
gs-4427	269	34	validation	validation	NOUN
gs-4427	269	35	.	.	PUNCT
gs-4427	270	1	regulatory	regulatory	ADJ
gs-4427	270	2	evolution	evolution	NOUN
gs-4427	270	3	and	and	CCONJ
gs-4427	270	4	adaptive	adaptive	ADJ
gs-4427	270	5	frameworks	framework	NOUN
gs-4427	270	6	the	the	DET
gs-4427	270	7	regulatory	regulatory	ADJ
gs-4427	270	8	landscape	landscape	NOUN
gs-4427	270	9	for	for	ADP
gs-4427	270	10	gene	gene	NOUN
gs-4427	270	11	therapy	therapy	NOUN
gs-4427	270	12	has	have	AUX
gs-4427	270	13	undergone	undergo	VERB
gs-4427	270	14	substantial	substantial	ADJ
gs-4427	270	15	evolution	evolution	NOUN
gs-4427	270	16	to	to	PART
gs-4427	270	17	accommodate	accommodate	VERB
gs-4427	270	18	the	the	DET
gs-4427	270	19	unique	unique	ADJ
gs-4427	270	20	characteristics	characteristic	NOUN
gs-4427	270	21	of	of	ADP
gs-4427	270	22	genetic	genetic	ADJ
gs-4427	270	23	medicines	medicine	NOUN
gs-4427	270	24	while	while	SCONJ
gs-4427	270	25	maintaining	maintain	VERB
gs-4427	270	26	appropriate	appropriate	ADJ
gs-4427	270	27	safety	safety	NOUN
gs-4427	270	28	oversight	oversight	NOUN
gs-4427	270	29	.	.	PUNCT
gs-4427	271	1	traditional	traditional	ADJ
gs-4427	271	2	drug	drug	NOUN
gs-4427	271	3	development	development	NOUN
gs-4427	271	4	paradigms	paradigm	NOUN
gs-4427	271	5	emphasizing	emphasize	VERB
gs-4427	271	6	large	large	ADJ
gs-4427	271	7	randomized	randomized	ADJ
gs-4427	271	8	controlled	control	VERB
gs-4427	271	9	trials	trial	NOUN
gs-4427	271	10	establishing	establish	VERB
gs-4427	271	11	safety	safety	NOUN
gs-4427	271	12	and	and	CCONJ
gs-4427	271	13	efficacy	efficacy	NOUN
gs-4427	271	14	through	through	ADP
gs-4427	271	15	comparison	comparison	NOUN
gs-4427	271	16	to	to	ADP
gs-4427	271	17	standard	standard	NOUN
gs-4427	271	18	of	of	ADP
gs-4427	271	19	care	care	NOUN
gs-4427	271	20	prove	prove	VERB
gs-4427	271	21	challenging	challenge	VERB
gs-4427	271	22	for	for	ADP
gs-4427	271	23	gene	gene	NOUN
gs-4427	271	24	therapies	therapy	NOUN
gs-4427	271	25	targeting	target	VERB
gs-4427	271	26	rare	rare	ADJ
gs-4427	271	27	diseases	disease	NOUN
gs-4427	271	28	where	where	SCONJ
gs-4427	271	29	patient	patient	ADJ
gs-4427	271	30	populations	population	NOUN
gs-4427	271	31	are	be	AUX
gs-4427	271	32	small	small	ADJ
gs-4427	271	33	,	,	PUNCT
gs-4427	271	34	disease	disease	NOUN
gs-4427	271	35	heterogeneity	heterogeneity	NOUN
gs-4427	271	36	is	be	AUX
gs-4427	271	37	high	high	ADJ
gs-4427	271	38	,	,	PUNCT
gs-4427	271	39	and	and	CCONJ
gs-4427	271	40	ethical	ethical	ADJ
gs-4427	271	41	concerns	concern	NOUN
gs-4427	271	42	arise	arise	VERB
gs-4427	271	43	regarding	regard	VERB
gs-4427	271	44	randomization	randomization	NOUN
gs-4427	271	45	to	to	ADP
gs-4427	271	46	placebo	placebo	NOUN
gs-4427	271	47	or	or	CCONJ
gs-4427	271	48	conventional	conventional	ADJ
gs-4427	271	49	therapy	therapy	NOUN
gs-4427	271	50	when	when	SCONJ
gs-4427	271	51	gene	gene	NOUN
gs-4427	271	52	therapy	therapy	NOUN
gs-4427	271	53	shows	show	VERB
gs-4427	271	54	promise	promise	NOUN
gs-4427	271	55	in	in	ADP
gs-4427	271	56	early	early	ADJ
gs-4427	271	57	studies	study	NOUN
gs-4427	271	58	.	.	PUNCT
gs-4427	272	1	regulatory	regulatory	ADJ
gs-4427	272	2	agencies	agency	NOUN
gs-4427	272	3	have	have	AUX
gs-4427	272	4	responded	respond	VERB
gs-4427	272	5	by	by	ADP
gs-4427	272	6	developing	develop	VERB
gs-4427	272	7	adaptive	adaptive	ADJ
gs-4427	272	8	frameworks	framework	NOUN
gs-4427	272	9	including	include	VERB
gs-4427	272	10	accelerated	accelerate	VERB
gs-4427	272	11	approval	approval	NOUN
gs-4427	272	12	pathways	pathway	NOUN
gs-4427	272	13	based	base	VERB
gs-4427	272	14	on	on	ADP
gs-4427	272	15	surrogate	surrogate	ADJ
gs-4427	272	16	endpoints	endpoint	NOUN
gs-4427	272	17	reasonably	reasonably	ADV
gs-4427	272	18	likely	likely	ADJ
gs-4427	272	19	to	to	PART
gs-4427	272	20	predict	predict	VERB
gs-4427	272	21	clinical	clinical	ADJ
gs-4427	272	22	benefit	benefit	NOUN
gs-4427	272	23	,	,	PUNCT
gs-4427	272	24	acceptance	acceptance	NOUN
gs-4427	272	25	of	of	ADP
gs-4427	272	26	smaller	small	ADJ
gs-4427	272	27	patient	patient	ADJ
gs-4427	272	28	numbers	number	NOUN
gs-4427	272	29	with	with	ADP
gs-4427	272	30	extended	extended	ADJ
gs-4427	272	31	follow	follow	NOUN
gs-4427	272	32	-	-	PUNCT
gs-4427	272	33	up	up	NOUN
gs-4427	272	34	for	for	ADP
gs-4427	272	35	rare	rare	ADJ
gs-4427	272	36	diseases	disease	NOUN
gs-4427	272	37	,	,	PUNCT
gs-4427	272	38	and	and	CCONJ
gs-4427	272	39	willingness	willingness	NOUN
gs-4427	272	40	to	to	PART
gs-4427	272	41	consider	consider	VERB
gs-4427	272	42	single	single	ADJ
gs-4427	272	43	-	-	PUNCT
gs-4427	272	44	arm	arm	NOUN
gs-4427	272	45	trials	trial	NOUN
gs-4427	272	46	with	with	ADP
gs-4427	272	47	historical	historical	ADJ
gs-4427	272	48	controls	control	NOUN
gs-4427	272	49	for	for	ADP
gs-4427	272	50	conditions	condition	NOUN
gs-4427	272	51	lacking	lack	VERB
gs-4427	272	52	effective	effective	ADJ
gs-4427	272	53	treatments	treatment	NOUN
gs-4427	272	54	.	.	PUNCT
gs-4427	273	1	the	the	DET
gs-4427	273	2	fda	fda	PROPN
gs-4427	273	3	's	's	PART
gs-4427	273	4	regenerative	regenerative	ADJ
gs-4427	273	5	medicine	medicine	NOUN
gs-4427	273	6	advanced	advanced	ADJ
gs-4427	273	7	therapy	therapy	NOUN
gs-4427	273	8	designation	designation	NOUN
gs-4427	273	9	,	,	PUNCT
gs-4427	273	10	established	establish	VERB
gs-4427	273	11	through	through	ADP
gs-4427	273	12	the	the	DET
gs-4427	273	13	21st	21st	ADJ
gs-4427	273	14	century	century	NOUN
gs-4427	273	15	cures	cure	NOUN
gs-4427	273	16	act	act	VERB
gs-4427	273	17	,	,	PUNCT
gs-4427	273	18	provides	provide	VERB
gs-4427	273	19	enhanced	enhanced	ADJ
gs-4427	273	20	interaction	interaction	NOUN
gs-4427	273	21	between	between	ADP
gs-4427	273	22	sponsors	sponsor	NOUN
gs-4427	273	23	and	and	CCONJ
gs-4427	273	24	the	the	DET
gs-4427	273	25	agency	agency	NOUN
gs-4427	273	26	during	during	ADP
gs-4427	273	27	development	development	NOUN
gs-4427	273	28	,	,	PUNCT
gs-4427	273	29	potential	potential	ADJ
gs-4427	273	30	eligibility	eligibility	NOUN
gs-4427	273	31	for	for	ADP
gs-4427	273	32	priority	priority	NOUN
gs-4427	273	33	article	article	NOUN
gs-4427	273	34	and	and	CCONJ
gs-4427	273	35	accelerated	accelerate	VERB
gs-4427	273	36	approval	approval	NOUN
gs-4427	273	37	,	,	PUNCT
gs-4427	273	38	and	and	CCONJ
gs-4427	273	39	access	access	NOUN
gs-4427	273	40	to	to	ADP
gs-4427	273	41	expedited	expedite	VERB
gs-4427	273	42	manufacturing	manufacturing	NOUN
gs-4427	273	43	development	development	NOUN
gs-4427	273	44	programs	program	NOUN
gs-4427	273	45	.	.	PUNCT
gs-4427	274	1	similar	similar	ADJ
gs-4427	274	2	mechanisms	mechanism	NOUN
gs-4427	274	3	exist	exist	VERB
gs-4427	274	4	in	in	ADP
gs-4427	274	5	europe	europe	PROPN
gs-4427	274	6	through	through	ADP
gs-4427	274	7	the	the	DET
gs-4427	274	8	prime	prime	ADJ
gs-4427	274	9	scheme	scheme	NOUN
gs-4427	274	10	and	and	CCONJ
gs-4427	274	11	in	in	ADP
gs-4427	274	12	other	other	ADJ
gs-4427	274	13	jurisdictions	jurisdiction	NOUN
gs-4427	274	14	,	,	PUNCT
gs-4427	274	15	reflecting	reflect	VERB
gs-4427	274	16	global	global	ADJ
gs-4427	274	17	recognition	recognition	NOUN
gs-4427	274	18	that	that	SCONJ
gs-4427	274	19	gene	gene	NOUN
gs-4427	274	20	therapy	therapy	NOUN
gs-4427	274	21	development	development	NOUN
gs-4427	274	22	requires	require	VERB
gs-4427	274	23	regulatory	regulatory	ADJ
gs-4427	274	24	flexibility	flexibility	NOUN
gs-4427	274	25	while	while	SCONJ
gs-4427	274	26	maintaining	maintain	VERB
gs-4427	274	27	safety	safety	NOUN
gs-4427	274	28	standards	standard	NOUN
gs-4427	274	29	.	.	PUNCT
gs-4427	275	1	the	the	DET
gs-4427	275	2	approval	approval	NOUN
gs-4427	275	3	of	of	ADP
gs-4427	275	4	casgevy	casgevy	NOUN
gs-4427	275	5	based	base	VERB
gs-4427	275	6	on	on	ADP
gs-4427	275	7	approximately	approximately	ADV
gs-4427	275	8	90	90	NUM
gs-4427	275	9	treated	treat	VERB
gs-4427	275	10	patients	patient	NOUN
gs-4427	275	11	across	across	ADP
gs-4427	275	12	sickle	sickle	NOUN
gs-4427	275	13	cell	cell	NOUN
gs-4427	275	14	disease	disease	NOUN
gs-4427	275	15	and	and	CCONJ
gs-4427	275	16	beta	beta	NOUN
gs-4427	275	17	thalassemia	thalassemia	NOUN
gs-4427	275	18	trials	trial	NOUN
gs-4427	275	19	with	with	ADP
gs-4427	275	20	median	median	ADJ
gs-4427	275	21	follow	follow	NOUN
gs-4427	275	22	-	-	PUNCT
gs-4427	275	23	up	up	NOUN
gs-4427	275	24	of	of	ADP
gs-4427	275	25	approximately	approximately	ADV
gs-4427	275	26	two	two	NUM
gs-4427	275	27	years	year	NOUN
gs-4427	275	28	demonstrates	demonstrate	VERB
gs-4427	275	29	regulatory	regulatory	ADJ
gs-4427	275	30	willingness	willingness	NOUN
gs-4427	275	31	to	to	PART
gs-4427	275	32	approve	approve	VERB
gs-4427	275	33	transformative	transformative	ADJ
gs-4427	275	34	therapies	therapy	NOUN
gs-4427	275	35	based	base	VERB
gs-4427	275	36	on	on	ADP
gs-4427	275	37	smaller	small	ADJ
gs-4427	275	38	datasets	dataset	NOUN
gs-4427	275	39	than	than	SCONJ
gs-4427	275	40	typically	typically	ADV
gs-4427	275	41	required	require	VERB
gs-4427	275	42	for	for	ADP
gs-4427	275	43	conventional	conventional	ADJ
gs-4427	275	44	drugs	drug	NOUN
gs-4427	275	45	,	,	PUNCT
gs-4427	275	46	accepting	accept	VERB
gs-4427	275	47	greater	great	ADJ
gs-4427	275	48	uncertainty	uncertainty	NOUN
gs-4427	275	49	regarding	regard	VERB
gs-4427	275	50	long	long	ADJ
gs-4427	275	51	-	-	PUNCT
gs-4427	275	52	term	term	NOUN
gs-4427	275	53	outcomes	outcome	NOUN
gs-4427	275	54	in	in	ADP
gs-4427	275	55	exchange	exchange	NOUN
gs-4427	275	56	for	for	ADP
gs-4427	275	57	earlier	early	ADJ
gs-4427	275	58	patient	patient	ADJ
gs-4427	275	59	access	access	NOUN
gs-4427	275	60	to	to	ADP
gs-4427	275	61	potentially	potentially	ADV
gs-4427	275	62	curative	curative	ADJ
gs-4427	275	63	treatments	treatment	NOUN
gs-4427	275	64	.	.	PUNCT
gs-4427	276	1	platform	platform	NOUN
gs-4427	276	2	technology	technology	NOUN
gs-4427	276	3	approaches	approach	NOUN
gs-4427	276	4	,	,	PUNCT
gs-4427	276	5	where	where	SCONJ
gs-4427	276	6	common	common	ADJ
gs-4427	276	7	manufacturing	manufacturing	NOUN
gs-4427	276	8	processes	process	NOUN
gs-4427	276	9	and	and	CCONJ
gs-4427	276	10	vector	vector	NOUN
gs-4427	276	11	systems	system	NOUN
gs-4427	276	12	are	be	AUX
gs-4427	276	13	adapted	adapt	VERB
gs-4427	276	14	for	for	ADP
gs-4427	276	15	different	different	ADJ
gs-4427	276	16	target	target	NOUN
gs-4427	276	17	genes	gene	NOUN
gs-4427	276	18	or	or	CCONJ
gs-4427	276	19	disease	disease	NOUN
gs-4427	276	20	indications	indication	NOUN
gs-4427	276	21	,	,	PUNCT
gs-4427	276	22	represent	represent	VERB
gs-4427	276	23	another	another	DET
gs-4427	276	24	area	area	NOUN
gs-4427	276	25	of	of	ADP
gs-4427	276	26	regulatory	regulatory	ADJ
gs-4427	276	27	innovation	innovation	NOUN
gs-4427	276	28	.	.	PUNCT
gs-4427	277	1	the	the	DET
gs-4427	277	2	approval	approval	NOUN
gs-4427	277	3	in	in	ADP
gs-4427	277	4	2025	2025	NUM
gs-4427	277	5	of	of	ADP
gs-4427	277	6	a	a	DET
gs-4427	277	7	personalized	personalize	VERB
gs-4427	277	8	crispr	crispr	NOUN
gs-4427	277	9	therapy	therapy	NOUN
gs-4427	277	10	developed	develop	VERB
gs-4427	277	11	and	and	CCONJ
gs-4427	277	12	delivered	deliver	VERB
gs-4427	277	13	within	within	ADP
gs-4427	277	14	six	six	NUM
gs-4427	277	15	months	month	NOUN
gs-4427	277	16	for	for	ADP
gs-4427	277	17	an	an	DET
gs-4427	277	18	infant	infant	NOUN
gs-4427	277	19	with	with	ADP
gs-4427	277	20	a	a	DET
gs-4427	277	21	unique	unique	ADJ
gs-4427	277	22	genetic	genetic	ADJ
gs-4427	277	23	condition	condition	NOUN
gs-4427	277	24	established	establish	VERB
gs-4427	277	25	precedent	precedent	NOUN
gs-4427	277	26	for	for	ADP
gs-4427	277	27	rapid	rapid	ADJ
gs-4427	277	28	development	development	NOUN
gs-4427	277	29	and	and	CCONJ
gs-4427	277	30	regulatory	regulatory	ADJ
gs-4427	277	31	authorization	authorization	NOUN
gs-4427	277	32	of	of	ADP
gs-4427	277	33	individualized	individualized	ADJ
gs-4427	277	34	treatments	treatment	NOUN
gs-4427	277	35	.	.	PUNCT
gs-4427	278	1	this	this	DET
gs-4427	278	2	approach	approach	NOUN
gs-4427	278	3	acknowledges	acknowledge	VERB
gs-4427	278	4	that	that	SCONJ
gs-4427	278	5	for	for	ADP
gs-4427	278	6	ultra	ultra	ADJ
gs-4427	278	7	-	-	ADJ
gs-4427	278	8	rare	rare	ADJ
gs-4427	278	9	genetic	genetic	ADJ
gs-4427	278	10	variants	variant	NOUN
gs-4427	278	11	affecting	affect	VERB
gs-4427	278	12	single	single	ADJ
gs-4427	278	13	or	or	CCONJ
gs-4427	278	14	few	few	ADJ
gs-4427	278	15	georgian	georgian	NOUN
gs-4427	278	16	scientists/	scientists/	NUM
gs-4427	278	17	.	.	PUNCT
gs-4427	278	18	7	7	NUM
gs-4427	278	19	n	n	PRON
gs-4427	278	20	4	4	NUM
gs-4427	278	21	,	,	PUNCT
gs-4427	278	22	2025	2025	NUM
gs-4427	278	23	648	648	NUM
gs-4427	278	24	patients	patient	NOUN
gs-4427	278	25	,	,	PUNCT
gs-4427	278	26	conducting	conduct	VERB
gs-4427	278	27	traditional	traditional	ADJ
gs-4427	278	28	clinical	clinical	ADJ
gs-4427	278	29	trials	trial	NOUN
gs-4427	278	30	is	be	AUX
gs-4427	278	31	impossible	impossible	ADJ
gs-4427	278	32	,	,	PUNCT
gs-4427	278	33	yet	yet	ADV
gs-4427	278	34	patients	patient	NOUN
gs-4427	278	35	deserve	deserve	VERB
gs-4427	278	36	access	access	NOUN
gs-4427	278	37	to	to	ADP
gs-4427	278	38	potentially	potentially	ADV
gs-4427	278	39	lifesaving	lifesave	VERB
gs-4427	278	40	therapies	therapy	NOUN
gs-4427	278	41	.	.	PUNCT
gs-4427	279	1	the	the	DET
gs-4427	279	2	regulatory	regulatory	ADJ
gs-4427	279	3	framework	framework	NOUN
gs-4427	279	4	evaluating	evaluate	VERB
gs-4427	279	5	platform	platform	NOUN
gs-4427	279	6	technology	technology	NOUN
gs-4427	279	7	safety	safety	NOUN
gs-4427	279	8	and	and	CCONJ
gs-4427	279	9	proof	proof	NOUN
gs-4427	279	10	-	-	PUNCT
gs-4427	279	11	of	of	ADP
gs-4427	279	12	-	-	PUNCT
gs-4427	279	13	concept	concept	NOUN
gs-4427	279	14	efficacy	efficacy	NOUN
gs-4427	279	15	,	,	PUNCT
gs-4427	279	16	then	then	ADV
gs-4427	279	17	enabling	enable	VERB
gs-4427	279	18	application	application	NOUN
gs-4427	279	19	to	to	ADP
gs-4427	279	20	new	new	ADJ
gs-4427	279	21	indications	indication	NOUN
gs-4427	279	22	through	through	ADP
gs-4427	279	23	streamlined	streamlined	ADJ
gs-4427	279	24	processes	process	NOUN
gs-4427	279	25	focusing	focus	VERB
gs-4427	279	26	on	on	ADP
gs-4427	279	27	indication	indication	NOUN
gs-4427	279	28	-	-	PUNCT
gs-4427	279	29	specific	specific	ADJ
gs-4427	279	30	considerations	consideration	NOUN
gs-4427	279	31	while	while	SCONJ
gs-4427	279	32	relying	rely	VERB
gs-4427	279	33	on	on	ADP
gs-4427	279	34	platform	platform	NOUN
gs-4427	279	35	-	-	PUNCT
gs-4427	279	36	level	level	NOUN
gs-4427	279	37	data	datum	NOUN
gs-4427	279	38	for	for	ADP
gs-4427	279	39	general	general	ADJ
gs-4427	279	40	safety	safety	NOUN
gs-4427	279	41	assessment	assessment	NOUN
gs-4427	279	42	,	,	PUNCT
gs-4427	279	43	could	could	AUX
gs-4427	279	44	dramatically	dramatically	ADV
gs-4427	279	45	accelerate	accelerate	VERB
gs-4427	279	46	access	access	NOUN
gs-4427	279	47	to	to	ADP
gs-4427	279	48	gene	gene	NOUN
gs-4427	279	49	therapies	therapy	NOUN
gs-4427	279	50	for	for	SCONJ
gs-4427	279	51	the	the	DET
gs-4427	279	52	thousands	thousand	NOUN
gs-4427	279	53	of	of	ADP
gs-4427	279	54	ultra	ultra	ADJ
gs-4427	279	55	-	-	ADJ
gs-4427	279	56	rare	rare	ADJ
gs-4427	279	57	genetic	genetic	ADJ
gs-4427	279	58	diseases	disease	NOUN
gs-4427	279	59	collectively	collectively	ADV
gs-4427	279	60	affecting	affect	VERB
gs-4427	279	61	substantial	substantial	ADJ
gs-4427	279	62	patient	patient	ADJ
gs-4427	279	63	populations	population	NOUN
gs-4427	279	64	but	but	CCONJ
gs-4427	279	65	individually	individually	ADV
gs-4427	279	66	too	too	ADV
gs-4427	279	67	rare	rare	ADJ
gs-4427	279	68	for	for	ADP
gs-4427	279	69	traditional	traditional	ADJ
gs-4427	279	70	development	development	NOUN
gs-4427	279	71	.	.	PUNCT
gs-4427	280	1	post	post	ADJ
gs-4427	280	2	-	-	ADJ
gs-4427	280	3	marketing	marketing	ADJ
gs-4427	280	4	surveillance	surveillance	NOUN
gs-4427	280	5	requirements	requirement	NOUN
gs-4427	280	6	for	for	ADP
gs-4427	280	7	gene	gene	NOUN
gs-4427	280	8	therapies	therapy	NOUN
gs-4427	280	9	reflect	reflect	VERB
gs-4427	280	10	ongoing	ongoing	ADJ
gs-4427	280	11	uncertainty	uncertainty	NOUN
gs-4427	280	12	regarding	regard	VERB
gs-4427	280	13	late	late	ADV
gs-4427	280	14	-	-	PUNCT
gs-4427	280	15	emerging	emerge	VERB
gs-4427	280	16	risks	risk	NOUN
gs-4427	280	17	including	include	VERB
gs-4427	280	18	insertional	insertional	ADJ
gs-4427	280	19	mutagenesis	mutagenesis	NOUN
gs-4427	280	20	,	,	PUNCT
gs-4427	280	21	delayed	delay	VERB
gs-4427	280	22	immune	immune	ADJ
gs-4427	280	23	responses	response	NOUN
gs-4427	280	24	,	,	PUNCT
gs-4427	280	25	and	and	CCONJ
gs-4427	280	26	unexpected	unexpected	ADJ
gs-4427	280	27	off	off	ADP
gs-4427	280	28	-	-	PUNCT
gs-4427	280	29	target	target	NOUN
gs-4427	280	30	effects	effect	NOUN
gs-4427	280	31	from	from	ADP
gs-4427	280	32	gene	gene	NOUN
gs-4427	280	33	editing	editing	NOUN
gs-4427	280	34	.	.	PUNCT
gs-4427	281	1	regulatory	regulatory	ADJ
gs-4427	281	2	agencies	agency	NOUN
gs-4427	281	3	typically	typically	ADV
gs-4427	281	4	require	require	VERB
gs-4427	281	5	15	15	NUM
gs-4427	281	6	-	-	PUNCT
gs-4427	281	7	year	year	NOUN
gs-4427	281	8	follow	follow	NOUN
gs-4427	281	9	-	-	PUNCT
gs-4427	281	10	up	up	NOUN
gs-4427	281	11	for	for	ADP
gs-4427	281	12	patients	patient	NOUN
gs-4427	281	13	receiving	receive	VERB
gs-4427	281	14	gene	gene	NOUN
gs-4427	281	15	therapies	therapy	NOUN
gs-4427	281	16	involving	involve	VERB
gs-4427	281	17	genomic	genomic	ADJ
gs-4427	281	18	integration	integration	NOUN
gs-4427	281	19	or	or	CCONJ
gs-4427	281	20	modification	modification	NOUN
gs-4427	281	21	,	,	PUNCT
gs-4427	281	22	implemented	implement	VERB
gs-4427	281	23	through	through	ADP
gs-4427	281	24	patient	patient	ADJ
gs-4427	281	25	registries	registry	NOUN
gs-4427	281	26	collecting	collect	VERB
gs-4427	281	27	standardized	standardized	ADJ
gs-4427	281	28	data	datum	NOUN
gs-4427	281	29	elements	element	NOUN
gs-4427	281	30	.	.	PUNCT
gs-4427	282	1	these	these	DET
gs-4427	282	2	registries	registry	NOUN
gs-4427	282	3	aim	aim	VERB
gs-4427	282	4	to	to	PART
gs-4427	282	5	detect	detect	VERB
gs-4427	282	6	safety	safety	NOUN
gs-4427	282	7	signals	signal	NOUN
gs-4427	282	8	that	that	PRON
gs-4427	282	9	might	might	AUX
gs-4427	282	10	emerge	emerge	VERB
gs-4427	282	11	with	with	ADP
gs-4427	282	12	longer	long	ADJ
gs-4427	282	13	follow	follow	VERB
gs-4427	282	14	-	-	PUNCT
gs-4427	282	15	up	up	NOUN
gs-4427	282	16	than	than	ADP
gs-4427	282	17	clinical	clinical	ADJ
gs-4427	282	18	trial	trial	NOUN
gs-4427	282	19	durations	duration	NOUN
gs-4427	282	20	while	while	SCONJ
gs-4427	282	21	minimizing	minimize	VERB
gs-4427	282	22	patient	patient	ADJ
gs-4427	282	23	burden	burden	NOUN
gs-4427	282	24	through	through	ADP
gs-4427	282	25	streamlined	streamlined	ADJ
gs-4427	282	26	data	datum	NOUN
gs-4427	282	27	collection	collection	NOUN
gs-4427	282	28	focused	focus	VERB
gs-4427	282	29	on	on	ADP
gs-4427	282	30	priority	priority	NOUN
gs-4427	282	31	safety	safety	NOUN
gs-4427	282	32	endpoints	endpoint	NOUN
gs-4427	282	33	.	.	PUNCT
gs-4427	283	1	however	however	ADV
gs-4427	283	2	,	,	PUNCT
gs-4427	283	3	achieving	achieve	VERB
gs-4427	283	4	high	high	ADJ
gs-4427	283	5	rates	rate	NOUN
gs-4427	283	6	of	of	ADP
gs-4427	283	7	long	long	ADJ
gs-4427	283	8	-	-	PUNCT
gs-4427	283	9	term	term	NOUN
gs-4427	283	10	follow	follow	NOUN
gs-4427	283	11	-	-	PUNCT
gs-4427	283	12	up	up	ADP
gs-4427	283	13	completion	completion	NOUN
gs-4427	283	14	remains	remain	VERB
gs-4427	283	15	challenging	challenge	VERB
gs-4427	283	16	as	as	SCONJ
gs-4427	283	17	patients	patient	NOUN
gs-4427	283	18	appropriately	appropriately	ADV
gs-4427	283	19	prioritize	prioritize	VERB
gs-4427	283	20	resuming	resume	VERB
gs-4427	283	21	normal	normal	ADJ
gs-4427	283	22	lives	life	NOUN
gs-4427	283	23	over	over	ADP
gs-4427	283	24	continued	continue	VERB
gs-4427	283	25	study	study	NOUN
gs-4427	283	26	participation	participation	NOUN
gs-4427	283	27	,	,	PUNCT
gs-4427	283	28	particularly	particularly	ADV
gs-4427	283	29	when	when	SCONJ
gs-4427	283	30	feeling	feel	VERB
gs-4427	283	31	well	well	ADV
gs-4427	283	32	and	and	CCONJ
gs-4427	283	33	not	not	PART
gs-4427	283	34	experiencing	experience	VERB
gs-4427	283	35	obvious	obvious	ADJ
gs-4427	283	36	problems	problem	NOUN
gs-4427	283	37	.	.	PUNCT
gs-4427	284	1	the	the	DET
gs-4427	284	2	development	development	NOUN
gs-4427	284	3	of	of	ADP
gs-4427	284	4	remote	remote	ADJ
gs-4427	284	5	monitoring	monitoring	NOUN
gs-4427	284	6	capabilities	capability	NOUN
gs-4427	284	7	including	include	VERB
gs-4427	284	8	patient	patient	NOUN
gs-4427	284	9	-	-	PUNCT
gs-4427	284	10	reported	report	VERB
gs-4427	284	11	outcomes	outcome	NOUN
gs-4427	284	12	collected	collect	VERB
gs-4427	284	13	through	through	ADP
gs-4427	284	14	smartphone	smartphone	NOUN
gs-4427	284	15	applications	application	NOUN
gs-4427	284	16	and	and	CCONJ
gs-4427	284	17	integration	integration	NOUN
gs-4427	284	18	with	with	ADP
gs-4427	284	19	electronic	electronic	ADJ
gs-4427	284	20	health	health	NOUN
gs-4427	284	21	record	record	NOUN
gs-4427	284	22	systems	system	NOUN
gs-4427	284	23	may	may	AUX
gs-4427	284	24	enhance	enhance	VERB
gs-4427	284	25	follow	follow	VERB
gs-4427	284	26	-	-	PUNCT
gs-4427	284	27	up	up	ADP
gs-4427	284	28	rates	rate	NOUN
gs-4427	284	29	while	while	SCONJ
gs-4427	284	30	reducing	reduce	VERB
gs-4427	284	31	patient	patient	ADJ
gs-4427	284	32	burden	burden	NOUN
gs-4427	284	33	.	.	PUNCT
gs-4427	285	1	technical	technical	ADJ
gs-4427	285	2	frontiers	frontier	NOUN
gs-4427	285	3	:	:	PUNCT
gs-4427	285	4	next	next	ADJ
gs-4427	285	5	-	-	PUNCT
gs-4427	285	6	generation	generation	NOUN
gs-4427	285	7	editing	editing	NOUN
gs-4427	285	8	and	and	CCONJ
gs-4427	285	9	delivery	delivery	NOUN
gs-4427	285	10	ongoing	ongoing	ADJ
gs-4427	285	11	technological	technological	ADJ
gs-4427	285	12	innovation	innovation	NOUN
gs-4427	285	13	promises	promise	VERB
gs-4427	285	14	to	to	PART
gs-4427	285	15	overcome	overcome	VERB
gs-4427	285	16	current	current	ADJ
gs-4427	285	17	gene	gene	NOUN
gs-4427	285	18	therapy	therapy	NOUN
gs-4427	285	19	limitations	limitation	NOUN
gs-4427	285	20	and	and	CCONJ
gs-4427	285	21	enable	enable	ADJ
gs-4427	285	22	applications	application	NOUN
gs-4427	285	23	beyond	beyond	ADP
gs-4427	285	24	present	present	ADJ
gs-4427	285	25	capabilities	capability	NOUN
gs-4427	285	26	.	.	PUNCT
gs-4427	286	1	base	base	NOUN
gs-4427	286	2	editing	editing	NOUN
gs-4427	286	3	and	and	CCONJ
gs-4427	286	4	prime	prime	ADJ
gs-4427	286	5	editing	editing	NOUN
gs-4427	286	6	represent	represent	VERB
gs-4427	286	7	next	next	ADJ
gs-4427	286	8	-	-	PUNCT
gs-4427	286	9	generation	generation	NOUN
gs-4427	286	10	genome	genome	NOUN
gs-4427	286	11	modification	modification	NOUN
gs-4427	286	12	tools	tool	NOUN
gs-4427	286	13	offering	offer	VERB
gs-4427	286	14	enhanced	enhance	VERB
gs-4427	286	15	precision	precision	NOUN
gs-4427	286	16	compared	compare	VERB
gs-4427	286	17	to	to	ADP
gs-4427	286	18	conventional	conventional	ADJ
gs-4427	286	19	crispr	crispr	ADJ
gs-4427	286	20	-	-	PUNCT
gs-4427	286	21	cas9	cas9	NOUN
gs-4427	286	22	editing	editing	NOUN
gs-4427	286	23	.	.	PUNCT
gs-4427	287	1	base	base	NOUN
gs-4427	287	2	editors	editor	NOUN
gs-4427	287	3	comprise	comprise	VERB
gs-4427	287	4	catalytically	catalytically	ADV
gs-4427	287	5	impaired	impair	VERB
gs-4427	287	6	cas9	cas9	NOUN
gs-4427	287	7	variants	variant	NOUN
gs-4427	287	8	fused	fuse	VERB
gs-4427	287	9	to	to	ADP
gs-4427	287	10	deaminase	deaminase	NOUN
gs-4427	287	11	enzymes	enzyme	NOUN
gs-4427	287	12	that	that	PRON
gs-4427	287	13	convert	convert	VERB
gs-4427	287	14	specific	specific	ADJ
gs-4427	287	15	nucleotides	nucleotide	NOUN
gs-4427	287	16	without	without	ADP
gs-4427	287	17	creating	create	VERB
gs-4427	287	18	double	double	ADJ
gs-4427	287	19	-	-	PUNCT
gs-4427	287	20	strand	strand	NOUN
gs-4427	287	21	breaks	break	NOUN
gs-4427	287	22	,	,	PUNCT
gs-4427	287	23	enabling	enable	VERB
gs-4427	287	24	correction	correction	NOUN
gs-4427	287	25	of	of	ADP
gs-4427	287	26	point	point	NOUN
gs-4427	287	27	mutations	mutation	NOUN
gs-4427	287	28	through	through	ADP
gs-4427	287	29	cto	cto	PROPN
gs-4427	287	30	-	-	PUNCT
gs-4427	287	31	t	t	PROPN
gs-4427	287	32	,	,	PUNCT
gs-4427	287	33	a	a	PRON
gs-4427	287	34	-	-	PUNCT
gs-4427	287	35	to	to	ADP
gs-4427	287	36	-	-	PUNCT
gs-4427	287	37	g	g	NOUN
gs-4427	287	38	,	,	PUNCT
gs-4427	287	39	or	or	CCONJ
gs-4427	287	40	reverse	reverse	ADJ
gs-4427	287	41	conversions	conversion	NOUN
gs-4427	287	42	depending	depend	VERB
gs-4427	287	43	on	on	ADP
gs-4427	287	44	the	the	DET
gs-4427	287	45	deaminase	deaminase	NOUN
gs-4427	287	46	employed	employ	VERB
gs-4427	287	47	.	.	PUNCT
gs-4427	288	1	this	this	DET
gs-4427	288	2	approach	approach	NOUN
gs-4427	288	3	addresses	address	VERB
gs-4427	288	4	safety	safety	NOUN
gs-4427	288	5	concerns	concern	NOUN
gs-4427	288	6	regarding	regard	VERB
gs-4427	288	7	chromosomal	chromosomal	ADJ
gs-4427	288	8	rearrangements	rearrangement	NOUN
gs-4427	288	9	and	and	CCONJ
gs-4427	288	10	large	large	ADJ
gs-4427	288	11	deletions	deletion	NOUN
gs-4427	288	12	potentially	potentially	ADV
gs-4427	288	13	resulting	result	VERB
gs-4427	288	14	from	from	ADP
gs-4427	288	15	double	double	ADJ
gs-4427	288	16	-	-	PUNCT
gs-4427	288	17	strand	strand	NOUN
gs-4427	288	18	break	break	NOUN
gs-4427	288	19	formation	formation	NOUN
gs-4427	288	20	and	and	CCONJ
gs-4427	288	21	subsequent	subsequent	ADJ
gs-4427	288	22	error	error	NOUN
gs-4427	288	23	-	-	PUNCT
gs-4427	288	24	prone	prone	ADJ
gs-4427	288	25	repair	repair	NOUN
gs-4427	288	26	.	.	PUNCT
gs-4427	289	1	early	early	ADJ
gs-4427	289	2	preclinical	preclinical	ADJ
gs-4427	289	3	studies	study	NOUN
gs-4427	289	4	demonstrate	demonstrate	VERB
gs-4427	289	5	efficient	efficient	ADJ
gs-4427	289	6	base	base	NOUN
gs-4427	289	7	editing	editing	NOUN
gs-4427	289	8	in	in	ADP
gs-4427	289	9	multiple	multiple	ADJ
gs-4427	289	10	therapeutically	therapeutically	ADV
gs-4427	289	11	relevant	relevant	ADJ
gs-4427	289	12	cell	cell	NOUN
gs-4427	289	13	types	type	NOUN
gs-4427	289	14	including	include	VERB
gs-4427	289	15	hematopoietic	hematopoietic	ADJ
gs-4427	289	16	stem	stem	NOUN
gs-4427	289	17	cells	cell	NOUN
gs-4427	289	18	,	,	PUNCT
gs-4427	289	19	hepatocytes	hepatocyte	NOUN
gs-4427	289	20	,	,	PUNCT
gs-4427	289	21	and	and	CCONJ
gs-4427	289	22	t	t	PROPN
gs-4427	289	23	lymphocytes	lymphocyte	VERB
gs-4427	289	24	,	,	PUNCT
gs-4427	289	25	with	with	ADP
gs-4427	289	26	several	several	ADJ
gs-4427	289	27	programs	program	NOUN
gs-4427	289	28	advancing	advance	VERB
gs-4427	289	29	toward	toward	ADP
gs-4427	289	30	clinical	clinical	ADJ
gs-4427	289	31	trials	trial	NOUN
gs-4427	289	32	for	for	ADP
gs-4427	289	33	diseases	disease	NOUN
gs-4427	289	34	including	include	VERB
gs-4427	289	35	sickle	sickle	NOUN
gs-4427	289	36	cell	cell	NOUN
gs-4427	289	37	disease	disease	NOUN
gs-4427	289	38	,	,	PUNCT
gs-4427	289	39	familial	familial	ADJ
gs-4427	289	40	hypercholesterolemia	hypercholesterolemia	NOUN
gs-4427	289	41	,	,	PUNCT
gs-4427	289	42	and	and	CCONJ
gs-4427	289	43	various	various	ADJ
gs-4427	289	44	cancers	cancer	NOUN
gs-4427	289	45	.	.	PUNCT
gs-4427	290	1	prime	prime	ADJ
gs-4427	290	2	editing	editing	NOUN
gs-4427	290	3	represents	represent	VERB
gs-4427	290	4	an	an	DET
gs-4427	290	5	even	even	ADV
gs-4427	290	6	more	more	ADV
gs-4427	290	7	sophisticated	sophisticated	ADJ
gs-4427	290	8	modification	modification	NOUN
gs-4427	290	9	approach	approach	NOUN
gs-4427	290	10	,	,	PUNCT
gs-4427	290	11	employing	employ	VERB
gs-4427	290	12	a	a	DET
gs-4427	290	13	catalytically	catalytically	ADV
gs-4427	290	14	impaired	impair	VERB
gs-4427	290	15	cas9	cas9	NOUN
gs-4427	290	16	fused	fuse	VERB
gs-4427	290	17	to	to	PART
gs-4427	290	18	reverse	reverse	VERB
gs-4427	290	19	transcriptase	transcriptase	NOUN
gs-4427	290	20	along	along	ADP
gs-4427	290	21	with	with	ADP
gs-4427	290	22	an	an	DET
gs-4427	290	23	extended	extended	ADJ
gs-4427	290	24	guide	guide	NOUN
gs-4427	290	25	rna	rna	NOUN
gs-4427	290	26	encoding	encode	VERB
gs-4427	290	27	both	both	CCONJ
gs-4427	290	28	the	the	DET
gs-4427	290	29	targeting	targeting	NOUN
gs-4427	290	30	sequence	sequence	NOUN
gs-4427	290	31	and	and	CCONJ
gs-4427	290	32	a	a	DET
gs-4427	290	33	template	template	NOUN
gs-4427	290	34	for	for	ADP
gs-4427	290	35	the	the	DET
gs-4427	290	36	desired	desire	VERB
gs-4427	290	37	modification	modification	NOUN
gs-4427	290	38	.	.	PUNCT
gs-4427	291	1	this	this	DET
gs-4427	291	2	georgian	georgian	NOUN
gs-4427	291	3	scientists/	scientists/	NUM
gs-4427	291	4	.	.	PUNCT
gs-4427	292	1	7	7	NUM
gs-4427	292	2	n	n	DET
gs-4427	292	3	4	4	NUM
gs-4427	292	4	,	,	PUNCT
gs-4427	292	5	2025	2025	NUM
gs-4427	292	6	649	649	NUM
gs-4427	292	7	system	system	NOUN
gs-4427	292	8	enables	enable	VERB
gs-4427	292	9	insertion	insertion	NOUN
gs-4427	292	10	,	,	PUNCT
gs-4427	292	11	deletion	deletion	NOUN
gs-4427	292	12	,	,	PUNCT
gs-4427	292	13	or	or	CCONJ
gs-4427	292	14	replacement	replacement	NOUN
gs-4427	292	15	of	of	ADP
gs-4427	292	16	dna	dna	PROPN
gs-4427	292	17	sequences	sequence	NOUN
gs-4427	292	18	up	up	ADP
gs-4427	292	19	to	to	ADP
gs-4427	292	20	approximately	approximately	ADV
gs-4427	292	21	80	80	NUM
gs-4427	292	22	base	base	NOUN
gs-4427	292	23	pairs	pair	NOUN
gs-4427	292	24	without	without	ADP
gs-4427	292	25	requiring	require	VERB
gs-4427	292	26	double	double	ADJ
gs-4427	292	27	-	-	PUNCT
gs-4427	292	28	strand	strand	NOUN
gs-4427	292	29	breaks	break	NOUN
gs-4427	292	30	or	or	CCONJ
gs-4427	292	31	separate	separate	ADJ
gs-4427	292	32	donor	donor	NOUN
gs-4427	292	33	dna	dna	PROPN
gs-4427	292	34	templates	template	NOUN
gs-4427	292	35	.	.	PUNCT
gs-4427	293	1	prime	prime	ADJ
gs-4427	293	2	editing	editing	NOUN
gs-4427	293	3	theoretically	theoretically	ADV
gs-4427	293	4	enables	enable	VERB
gs-4427	293	5	correction	correction	NOUN
gs-4427	293	6	of	of	ADP
gs-4427	293	7	the	the	DET
gs-4427	293	8	majority	majority	NOUN
gs-4427	293	9	of	of	ADP
gs-4427	293	10	known	know	VERB
gs-4427	293	11	pathogenic	pathogenic	ADJ
gs-4427	293	12	mutations	mutation	NOUN
gs-4427	293	13	including	include	VERB
gs-4427	293	14	all	all	DET
gs-4427	293	15	classes	class	NOUN
gs-4427	293	16	of	of	ADP
gs-4427	293	17	point	point	NOUN
gs-4427	293	18	mutations	mutation	NOUN
gs-4427	293	19	,	,	PUNCT
gs-4427	293	20	small	small	ADJ
gs-4427	293	21	insertions	insertion	NOUN
gs-4427	293	22	and	and	CCONJ
gs-4427	293	23	deletions	deletion	NOUN
gs-4427	293	24	,	,	PUNCT
gs-4427	293	25	and	and	CCONJ
gs-4427	293	26	even	even	ADV
gs-4427	293	27	some	some	DET
gs-4427	293	28	larger	large	ADJ
gs-4427	293	29	sequence	sequence	NOUN
gs-4427	293	30	changes	change	NOUN
gs-4427	293	31	,	,	PUNCT
gs-4427	293	32	potentially	potentially	ADV
gs-4427	293	33	addressing	address	VERB
gs-4427	293	34	a	a	DET
gs-4427	293	35	broader	broad	ADJ
gs-4427	293	36	range	range	NOUN
gs-4427	293	37	of	of	ADP
gs-4427	293	38	genetic	genetic	ADJ
gs-4427	293	39	diseases	disease	NOUN
gs-4427	293	40	than	than	ADP
gs-4427	293	41	base	base	NOUN
gs-4427	293	42	editors	editor	NOUN
gs-4427	293	43	or	or	CCONJ
gs-4427	293	44	conventional	conventional	ADJ
gs-4427	293	45	crispr	crispr	ADJ
gs-4427	293	46	systems	system	NOUN
gs-4427	293	47	.	.	PUNCT
gs-4427	294	1	however	however	ADV
gs-4427	294	2	,	,	PUNCT
gs-4427	294	3	prime	prime	ADJ
gs-4427	294	4	editing	editing	NOUN
gs-4427	294	5	efficiency	efficiency	NOUN
gs-4427	294	6	in	in	ADP
gs-4427	294	7	primary	primary	ADJ
gs-4427	294	8	human	human	ADJ
gs-4427	294	9	cells	cell	NOUN
gs-4427	294	10	relevant	relevant	ADJ
gs-4427	294	11	for	for	ADP
gs-4427	294	12	therapeutic	therapeutic	ADJ
gs-4427	294	13	applications	application	NOUN
gs-4427	294	14	has	have	AUX
gs-4427	294	15	proven	prove	VERB
gs-4427	294	16	more	more	ADV
gs-4427	294	17	challenging	challenging	ADJ
gs-4427	294	18	than	than	ADP
gs-4427	294	19	in	in	ADP
gs-4427	294	20	established	establish	VERB
gs-4427	294	21	cell	cell	NOUN
gs-4427	294	22	lines	line	NOUN
gs-4427	294	23	,	,	PUNCT
gs-4427	294	24	necessitating	necessitate	VERB
gs-4427	294	25	continued	continue	VERB
gs-4427	294	26	optimization	optimization	NOUN
gs-4427	294	27	before	before	ADP
gs-4427	294	28	clinical	clinical	ADJ
gs-4427	294	29	translation	translation	NOUN
gs-4427	294	30	.	.	PUNCT
gs-4427	295	1	the	the	DET
gs-4427	295	2	combination	combination	NOUN
gs-4427	295	3	of	of	ADP
gs-4427	295	4	prime	prime	ADJ
gs-4427	295	5	editing	editing	NOUN
gs-4427	295	6	with	with	ADP
gs-4427	295	7	delivery	delivery	NOUN
gs-4427	295	8	system	system	NOUN
gs-4427	295	9	innovations	innovation	NOUN
gs-4427	295	10	may	may	AUX
gs-4427	295	11	enable	enable	VERB
gs-4427	295	12	in	in	ADP
gs-4427	295	13	vivo	vivo	ADJ
gs-4427	295	14	correction	correction	NOUN
gs-4427	295	15	of	of	ADP
gs-4427	295	16	previously	previously	ADV
gs-4427	295	17	intractable	intractable	ADJ
gs-4427	295	18	disease	disease	NOUN
gs-4427	295	19	-	-	PUNCT
gs-4427	295	20	causing	cause	VERB
gs-4427	295	21	mutations	mutation	NOUN
gs-4427	295	22	.	.	PUNCT
gs-4427	296	1	delivery	delivery	NOUN
gs-4427	296	2	system	system	NOUN
gs-4427	296	3	development	development	NOUN
gs-4427	296	4	represents	represent	VERB
gs-4427	296	5	another	another	DET
gs-4427	296	6	critical	critical	ADJ
gs-4427	296	7	frontier	frontier	NOUN
gs-4427	296	8	,	,	PUNCT
gs-4427	296	9	as	as	SCONJ
gs-4427	296	10	achieving	achieve	VERB
gs-4427	296	11	efficient	efficient	ADJ
gs-4427	296	12	gene	gene	NOUN
gs-4427	296	13	transfer	transfer	NOUN
gs-4427	296	14	or	or	CCONJ
gs-4427	296	15	editing	edit	VERB
gs-4427	296	16	in	in	ADP
gs-4427	296	17	target	target	NOUN
gs-4427	296	18	tissues	tissue	NOUN
gs-4427	296	19	while	while	SCONJ
gs-4427	296	20	minimizing	minimize	VERB
gs-4427	296	21	off	off	ADP
gs-4427	296	22	-	-	PUNCT
gs-4427	296	23	target	target	NOUN
gs-4427	296	24	delivery	delivery	NOUN
gs-4427	296	25	and	and	CCONJ
gs-4427	296	26	toxicity	toxicity	NOUN
gs-4427	296	27	remains	remain	VERB
gs-4427	296	28	challenging	challenge	VERB
gs-4427	296	29	for	for	ADP
gs-4427	296	30	many	many	ADJ
gs-4427	296	31	organs	organ	NOUN
gs-4427	296	32	.	.	PUNCT
gs-4427	297	1	lipid	lipid	NOUN
gs-4427	297	2	nanoparticle	nanoparticle	NOUN
gs-4427	297	3	delivery	delivery	NOUN
gs-4427	297	4	systems	system	NOUN
gs-4427	297	5	,	,	PUNCT
gs-4427	297	6	validated	validate	VERB
gs-4427	297	7	through	through	ADP
gs-4427	297	8	covid-19	covid-19	PROPN
gs-4427	297	9	mrna	mrna	PROPN
gs-4427	297	10	vaccine	vaccine	NOUN
gs-4427	297	11	success	success	NOUN
gs-4427	297	12	,	,	PUNCT
gs-4427	297	13	are	be	AUX
gs-4427	297	14	being	be	AUX
gs-4427	297	15	optimized	optimize	VERB
gs-4427	297	16	for	for	ADP
gs-4427	297	17	therapeutic	therapeutic	ADJ
gs-4427	297	18	applications	application	NOUN
gs-4427	297	19	including	include	VERB
gs-4427	297	20	crispr	crispr	ADJ
gs-4427	297	21	component	component	NOUN
gs-4427	297	22	delivery	delivery	NOUN
gs-4427	297	23	for	for	ADP
gs-4427	297	24	in	in	ADP
gs-4427	297	25	vivo	vivo	NOUN
gs-4427	297	26	editing	editing	NOUN
gs-4427	297	27	and	and	CCONJ
gs-4427	297	28	mrna	mrna	PROPN
gs-4427	297	29	delivery	delivery	NOUN
gs-4427	297	30	for	for	ADP
gs-4427	297	31	transient	transient	ADJ
gs-4427	297	32	protein	protein	NOUN
gs-4427	297	33	expression	expression	NOUN
gs-4427	297	34	.	.	PUNCT
gs-4427	298	1	the	the	DET
gs-4427	298	2	development	development	NOUN
gs-4427	298	3	of	of	ADP
gs-4427	298	4	tissue	tissue	NOUN
gs-4427	298	5	-	-	PUNCT
gs-4427	298	6	specific	specific	ADJ
gs-4427	298	7	lipid	lipid	NOUN
gs-4427	298	8	formulations	formulation	NOUN
gs-4427	298	9	incorporating	incorporate	VERB
gs-4427	298	10	targeting	target	VERB
gs-4427	298	11	ligands	ligand	NOUN
gs-4427	298	12	that	that	PRON
gs-4427	298	13	bind	bind	VERB
gs-4427	298	14	receptors	receptor	NOUN
gs-4427	298	15	enriched	enrich	VERB
gs-4427	298	16	on	on	ADP
gs-4427	298	17	desired	desire	VERB
gs-4427	298	18	cell	cell	NOUN
gs-4427	298	19	types	type	NOUN
gs-4427	298	20	aims	aim	VERB
gs-4427	298	21	to	to	PART
gs-4427	298	22	enhance	enhance	VERB
gs-4427	298	23	delivery	delivery	NOUN
gs-4427	298	24	specificity	specificity	NOUN
gs-4427	298	25	,	,	PUNCT
gs-4427	298	26	potentially	potentially	ADV
gs-4427	298	27	enabling	enable	VERB
gs-4427	298	28	efficient	efficient	ADJ
gs-4427	298	29	gene	gene	NOUN
gs-4427	298	30	transfer	transfer	NOUN
gs-4427	298	31	to	to	ADP
gs-4427	298	32	tissues	tissue	NOUN
gs-4427	298	33	currently	currently	ADV
gs-4427	298	34	difficult	difficult	ADJ
gs-4427	298	35	to	to	PART
gs-4427	298	36	target	target	VERB
gs-4427	298	37	including	include	VERB
gs-4427	298	38	lung	lung	NOUN
gs-4427	298	39	,	,	PUNCT
gs-4427	298	40	heart	heart	NOUN
gs-4427	298	41	,	,	PUNCT
gs-4427	298	42	and	and	CCONJ
gs-4427	298	43	brain	brain	NOUN
gs-4427	298	44	.	.	PUNCT
gs-4427	299	1	exosome	exosome	NOUN
gs-4427	299	2	-	-	PUNCT
gs-4427	299	3	based	base	VERB
gs-4427	299	4	delivery	delivery	NOUN
gs-4427	299	5	systems	system	NOUN
gs-4427	299	6	utilizing	utilize	VERB
gs-4427	299	7	naturally	naturally	ADV
gs-4427	299	8	occurring	occur	VERB
gs-4427	299	9	cell	cell	NOUN
gs-4427	299	10	-	-	PUNCT
gs-4427	299	11	derived	derive	VERB
gs-4427	299	12	vesicles	vesicle	NOUN
gs-4427	299	13	capable	capable	ADJ
gs-4427	299	14	of	of	ADP
gs-4427	299	15	crossing	cross	VERB
gs-4427	299	16	biological	biological	ADJ
gs-4427	299	17	barriers	barrier	NOUN
gs-4427	299	18	and	and	CCONJ
gs-4427	299	19	delivering	deliver	VERB
gs-4427	299	20	cargo	cargo	NOUN
gs-4427	299	21	to	to	PART
gs-4427	299	22	recipient	recipient	NOUN
gs-4427	299	23	cells	cell	NOUN
gs-4427	299	24	represent	represent	VERB
gs-4427	299	25	another	another	DET
gs-4427	299	26	innovative	innovative	ADJ
gs-4427	299	27	approach	approach	NOUN
gs-4427	299	28	under	under	ADP
gs-4427	299	29	preclinical	preclinical	ADJ
gs-4427	299	30	investigation	investigation	NOUN
gs-4427	299	31	,	,	PUNCT
gs-4427	299	32	potentially	potentially	ADV
gs-4427	299	33	offering	offer	VERB
gs-4427	299	34	lower	low	ADJ
gs-4427	299	35	immunogenicity	immunogenicity	NOUN
gs-4427	299	36	than	than	ADP
gs-4427	299	37	synthetic	synthetic	ADJ
gs-4427	299	38	delivery	delivery	NOUN
gs-4427	299	39	vehicles	vehicle	NOUN
gs-4427	299	40	.	.	PUNCT
gs-4427	300	1	aav	aav	PROPN
gs-4427	300	2	capsid	capsid	VERB
gs-4427	300	3	engineering	engineering	NOUN
gs-4427	300	4	through	through	ADP
gs-4427	300	5	directed	direct	VERB
gs-4427	300	6	evolution	evolution	NOUN
gs-4427	300	7	and	and	CCONJ
gs-4427	300	8	rational	rational	ADJ
gs-4427	300	9	design	design	NOUN
gs-4427	300	10	has	have	AUX
gs-4427	300	11	generated	generate	VERB
gs-4427	300	12	variants	variant	NOUN
gs-4427	300	13	with	with	ADP
gs-4427	300	14	enhanced	enhanced	ADJ
gs-4427	300	15	properties	property	NOUN
gs-4427	300	16	including	include	VERB
gs-4427	300	17	improved	improve	VERB
gs-4427	300	18	transduction	transduction	NOUN
gs-4427	300	19	efficiency	efficiency	NOUN
gs-4427	300	20	,	,	PUNCT
gs-4427	300	21	altered	alter	VERB
gs-4427	300	22	tissue	tissue	NOUN
gs-4427	300	23	tropism	tropism	NOUN
gs-4427	300	24	,	,	PUNCT
gs-4427	300	25	reduced	reduce	VERB
gs-4427	300	26	antibody	antibody	NOUN
gs-4427	300	27	neutralization	neutralization	NOUN
gs-4427	300	28	,	,	PUNCT
gs-4427	300	29	and	and	CCONJ
gs-4427	300	30	decreased	decrease	VERB
gs-4427	300	31	immunogenicity	immunogenicity	NOUN
gs-4427	300	32	.	.	PUNCT
gs-4427	301	1	highthroughput	highthroughput	VERB
gs-4427	301	2	screening	screen	VERB
gs-4427	301	3	approaches	approach	NOUN
gs-4427	301	4	evaluating	evaluate	VERB
gs-4427	301	5	large	large	ADJ
gs-4427	301	6	capsid	capsid	ADJ
gs-4427	301	7	variant	variant	NOUN
gs-4427	301	8	libraries	library	NOUN
gs-4427	301	9	in	in	ADP
gs-4427	301	10	relevant	relevant	ADJ
gs-4427	301	11	disease	disease	NOUN
gs-4427	301	12	models	model	NOUN
gs-4427	301	13	enable	enable	VERB
gs-4427	301	14	identification	identification	NOUN
gs-4427	301	15	of	of	ADP
gs-4427	301	16	variants	variant	NOUN
gs-4427	301	17	with	with	ADP
gs-4427	301	18	desired	desire	VERB
gs-4427	301	19	characteristics	characteristic	NOUN
gs-4427	301	20	.	.	PUNCT
gs-4427	302	1	several	several	ADJ
gs-4427	302	2	engineered	engineer	VERB
gs-4427	302	3	aav	aav	NOUN
gs-4427	302	4	variants	variant	NOUN
gs-4427	302	5	have	have	AUX
gs-4427	302	6	advanced	advance	VERB
gs-4427	302	7	to	to	ADP
gs-4427	302	8	clinical	clinical	ADJ
gs-4427	302	9	trials	trial	NOUN
gs-4427	302	10	,	,	PUNCT
gs-4427	302	11	including	include	VERB
gs-4427	302	12	capsids	capsid	NOUN
gs-4427	302	13	selected	select	VERB
gs-4427	302	14	for	for	ADP
gs-4427	302	15	enhanced	enhanced	ADJ
gs-4427	302	16	central	central	ADJ
gs-4427	302	17	nervous	nervous	ADJ
gs-4427	302	18	system	system	NOUN
gs-4427	302	19	transduction	transduction	NOUN
gs-4427	302	20	following	follow	VERB
gs-4427	302	21	systemic	systemic	ADJ
gs-4427	302	22	administration	administration	NOUN
gs-4427	302	23	,	,	PUNCT
gs-4427	302	24	potentially	potentially	ADV
gs-4427	302	25	enabling	enable	VERB
gs-4427	302	26	treatment	treatment	NOUN
gs-4427	302	27	of	of	ADP
gs-4427	302	28	neurodegenerative	neurodegenerative	ADJ
gs-4427	302	29	diseases	disease	NOUN
gs-4427	302	30	without	without	ADP
gs-4427	302	31	requiring	require	VERB
gs-4427	302	32	direct	direct	ADJ
gs-4427	302	33	brain	brain	NOUN
gs-4427	302	34	injection	injection	NOUN
gs-4427	302	35	.	.	PUNCT
gs-4427	303	1	the	the	DET
gs-4427	303	2	discovery	discovery	NOUN
gs-4427	303	3	that	that	PRON
gs-4427	303	4	some	some	DET
gs-4427	303	5	engineered	engineer	VERB
gs-4427	303	6	capsids	capsid	NOUN
gs-4427	303	7	demonstrate	demonstrate	VERB
gs-4427	303	8	reduced	reduce	VERB
gs-4427	303	9	neutralization	neutralization	NOUN
gs-4427	303	10	by	by	ADP
gs-4427	303	11	antibodies	antibody	NOUN
gs-4427	303	12	against	against	ADP
gs-4427	303	13	natural	natural	ADJ
gs-4427	303	14	serotypes	serotype	NOUN
gs-4427	303	15	suggests	suggest	VERB
gs-4427	303	16	possibility	possibility	NOUN
gs-4427	303	17	of	of	ADP
gs-4427	303	18	treating	treat	VERB
gs-4427	303	19	seropositive	seropositive	ADJ
gs-4427	303	20	patient	patient	ADJ
gs-4427	303	21	populations	population	NOUN
gs-4427	303	22	currently	currently	ADV
gs-4427	303	23	excluded	exclude	VERB
gs-4427	303	24	from	from	ADP
gs-4427	303	25	aav	aav	NOUN
gs-4427	303	26	gene	gene	NOUN
gs-4427	303	27	therapy	therapy	NOUN
gs-4427	303	28	,	,	PUNCT
gs-4427	303	29	substantially	substantially	ADV
gs-4427	303	30	expanding	expand	VERB
gs-4427	303	31	eligible	eligible	ADJ
gs-4427	303	32	populations	population	NOUN
gs-4427	303	33	if	if	SCONJ
gs-4427	303	34	confirmed	confirm	VERB
gs-4427	303	35	in	in	ADP
gs-4427	303	36	clinical	clinical	ADJ
gs-4427	303	37	trials	trial	NOUN
gs-4427	303	38	.	.	PUNCT
gs-4427	304	1	lessons	lesson	NOUN
gs-4427	304	2	from	from	ADP
gs-4427	304	3	clinical	clinical	ADJ
gs-4427	304	4	translation	translation	NOUN
gs-4427	304	5	and	and	CCONJ
gs-4427	304	6	remaining	remain	VERB
gs-4427	304	7	questions	question	NOUN
gs-4427	304	8	the	the	DET
gs-4427	304	9	successful	successful	ADJ
gs-4427	304	10	clinical	clinical	ADJ
gs-4427	304	11	translation	translation	NOUN
gs-4427	304	12	of	of	ADP
gs-4427	304	13	multiple	multiple	ADJ
gs-4427	304	14	gene	gene	NOUN
gs-4427	304	15	therapy	therapy	NOUN
gs-4427	304	16	modalities	modality	NOUN
gs-4427	304	17	from	from	ADP
gs-4427	304	18	preclinical	preclinical	ADJ
gs-4427	304	19	concept	concept	NOUN
gs-4427	304	20	to	to	ADP
gs-4427	304	21	approved	approve	VERB
gs-4427	304	22	products	product	NOUN
gs-4427	304	23	provides	provide	VERB
gs-4427	304	24	valuable	valuable	ADJ
gs-4427	304	25	lessons	lesson	NOUN
gs-4427	304	26	applicable	applicable	ADJ
gs-4427	304	27	to	to	ADP
gs-4427	304	28	ongoing	ongoing	ADJ
gs-4427	304	29	development	development	NOUN
gs-4427	304	30	programs	program	NOUN
gs-4427	304	31	and	and	CCONJ
gs-4427	304	32	future	future	ADJ
gs-4427	304	33	innovations	innovation	NOUN
gs-4427	304	34	.	.	PUNCT
gs-4427	305	1	the	the	DET
gs-4427	305	2	importance	importance	NOUN
gs-4427	305	3	of	of	ADP
gs-4427	305	4	robust	robust	ADJ
gs-4427	305	5	preclinical	preclinical	ADJ
gs-4427	305	6	studies	study	NOUN
gs-4427	305	7	in	in	ADP
gs-4427	305	8	diseasegeorgian	diseasegeorgian	ADJ
gs-4427	305	9	scientists/	scientists/	NUM
gs-4427	305	10	.	.	PUNCT
gs-4427	306	1	7	7	NUM
gs-4427	306	2	n	n	PRON
gs-4427	306	3	4	4	NUM
gs-4427	306	4	,	,	PUNCT
gs-4427	306	5	2025	2025	NUM
gs-4427	306	6	650	650	NUM
gs-4427	306	7	relevant	relevant	ADJ
gs-4427	306	8	animal	animal	NOUN
gs-4427	306	9	models	model	NOUN
gs-4427	306	10	,	,	PUNCT
gs-4427	306	11	including	include	VERB
gs-4427	306	12	large	large	ADJ
gs-4427	306	13	animal	animal	NOUN
gs-4427	306	14	models	model	NOUN
gs-4427	306	15	with	with	ADP
gs-4427	306	16	anatomy	anatomy	NOUN
gs-4427	306	17	and	and	CCONJ
gs-4427	306	18	physiology	physiology	NOUN
gs-4427	306	19	more	more	ADV
gs-4427	306	20	closely	closely	ADV
gs-4427	306	21	approximating	approximate	VERB
gs-4427	306	22	humans	human	NOUN
gs-4427	306	23	,	,	PUNCT
gs-4427	306	24	has	have	AUX
gs-4427	306	25	been	be	AUX
gs-4427	306	26	repeatedly	repeatedly	ADV
gs-4427	306	27	demonstrated	demonstrate	VERB
gs-4427	306	28	.	.	PUNCT
gs-4427	307	1	early	early	ADJ
gs-4427	307	2	gene	gene	NOUN
gs-4427	307	3	therapy	therapy	NOUN
gs-4427	307	4	failures	failure	NOUN
gs-4427	307	5	partly	partly	ADV
gs-4427	307	6	resulted	result	VERB
gs-4427	307	7	from	from	ADP
gs-4427	307	8	inadequate	inadequate	ADJ
gs-4427	307	9	preclinical	preclinical	ADJ
gs-4427	307	10	characterization	characterization	NOUN
gs-4427	307	11	of	of	ADP
gs-4427	307	12	immune	immune	ADJ
gs-4427	307	13	responses	response	NOUN
gs-4427	307	14	and	and	CCONJ
gs-4427	307	15	toxicities	toxicity	NOUN
gs-4427	307	16	that	that	PRON
gs-4427	307	17	manifested	manifest	VERB
gs-4427	307	18	differently	differently	ADV
gs-4427	307	19	in	in	ADP
gs-4427	307	20	human	human	ADJ
gs-4427	307	21	patients	patient	NOUN
gs-4427	307	22	compared	compare	VERB
gs-4427	307	23	to	to	ADP
gs-4427	307	24	small	small	ADJ
gs-4427	307	25	animal	animal	NOUN
gs-4427	307	26	models	model	NOUN
gs-4427	307	27	.	.	PUNCT
gs-4427	308	1	contemporary	contemporary	ADJ
gs-4427	308	2	development	development	NOUN
gs-4427	308	3	programs	program	NOUN
gs-4427	308	4	incorporate	incorporate	VERB
gs-4427	308	5	extensive	extensive	ADJ
gs-4427	308	6	toxicology	toxicology	NOUN
gs-4427	308	7	studies	study	NOUN
gs-4427	308	8	in	in	ADP
gs-4427	308	9	non	non	ADJ
gs-4427	308	10	-	-	ADJ
gs-4427	308	11	human	human	ADJ
gs-4427	308	12	primates	primate	NOUN
gs-4427	308	13	evaluating	evaluate	VERB
gs-4427	308	14	dose	dose	NOUN
gs-4427	308	15	-	-	PUNCT
gs-4427	308	16	dependent	dependent	ADJ
gs-4427	308	17	effects	effect	NOUN
gs-4427	308	18	,	,	PUNCT
gs-4427	308	19	comprehensive	comprehensive	ADJ
gs-4427	308	20	biodistribution	biodistribution	NOUN
gs-4427	308	21	analyses	analyse	VERB
gs-4427	308	22	determining	determine	VERB
gs-4427	308	23	vector	vector	NOUN
gs-4427	308	24	distribution	distribution	NOUN
gs-4427	308	25	across	across	ADP
gs-4427	308	26	tissues	tissue	NOUN
gs-4427	308	27	,	,	PUNCT
gs-4427	308	28	and	and	CCONJ
gs-4427	308	29	immunogenicity	immunogenicity	NOUN
gs-4427	308	30	assessments	assessment	NOUN
gs-4427	308	31	characterizing	characterize	VERB
gs-4427	308	32	both	both	CCONJ
gs-4427	308	33	cellular	cellular	ADJ
gs-4427	308	34	and	and	CCONJ
gs-4427	308	35	humoral	humoral	ADJ
gs-4427	308	36	responses	response	NOUN
gs-4427	308	37	.	.	PUNCT
gs-4427	309	1	while	while	SCONJ
gs-4427	309	2	these	these	DET
gs-4427	309	3	studies	study	NOUN
gs-4427	309	4	increase	increase	VERB
gs-4427	309	5	development	development	NOUN
gs-4427	309	6	timelines	timeline	NOUN
gs-4427	309	7	and	and	CCONJ
gs-4427	309	8	costs	cost	NOUN
gs-4427	309	9	,	,	PUNCT
gs-4427	309	10	they	they	PRON
gs-4427	309	11	provide	provide	VERB
gs-4427	309	12	critical	critical	ADJ
gs-4427	309	13	safety	safety	NOUN
gs-4427	309	14	data	datum	NOUN
gs-4427	309	15	informing	inform	VERB
gs-4427	309	16	starting	start	VERB
gs-4427	309	17	doses	dose	NOUN
gs-4427	309	18	,	,	PUNCT
gs-4427	309	19	monitoring	monitoring	NOUN
gs-4427	309	20	strategies	strategy	NOUN
gs-4427	309	21	,	,	PUNCT
gs-4427	309	22	and	and	CCONJ
gs-4427	309	23	risk	risk	NOUN
gs-4427	309	24	mitigation	mitigation	NOUN
gs-4427	309	25	approaches	approach	NOUN
gs-4427	309	26	for	for	ADP
gs-4427	309	27	first	first	ADJ
gs-4427	309	28	-	-	PUNCT
gs-4427	309	29	in	in	ADP
gs-4427	309	30	-	-	PUNCT
gs-4427	309	31	human	human	ADJ
gs-4427	309	32	trials	trial	NOUN
gs-4427	309	33	.	.	PUNCT
gs-4427	310	1	the	the	DET
gs-4427	310	2	selection	selection	NOUN
gs-4427	310	3	of	of	ADP
gs-4427	310	4	appropriate	appropriate	ADJ
gs-4427	310	5	initial	initial	ADJ
gs-4427	310	6	disease	disease	NOUN
gs-4427	310	7	targets	target	NOUN
gs-4427	310	8	represents	represent	VERB
gs-4427	310	9	another	another	DET
gs-4427	310	10	critical	critical	ADJ
gs-4427	310	11	success	success	NOUN
gs-4427	310	12	factor	factor	NOUN
gs-4427	310	13	,	,	PUNCT
gs-4427	310	14	with	with	ADP
gs-4427	310	15	most	most	ADV
gs-4427	310	16	successful	successful	ADJ
gs-4427	310	17	gene	gene	NOUN
gs-4427	310	18	therapy	therapy	NOUN
gs-4427	310	19	programs	program	NOUN
gs-4427	310	20	initially	initially	ADV
gs-4427	310	21	targeting	target	VERB
gs-4427	310	22	monogenic	monogenic	ADJ
gs-4427	310	23	disorders	disorder	NOUN
gs-4427	310	24	affecting	affect	VERB
gs-4427	310	25	accessible	accessible	ADJ
gs-4427	310	26	tissues	tissue	NOUN
gs-4427	310	27	with	with	ADP
gs-4427	310	28	validated	validate	VERB
gs-4427	310	29	animal	animal	NOUN
gs-4427	310	30	models	model	NOUN
gs-4427	310	31	and	and	CCONJ
gs-4427	310	32	significant	significant	ADJ
gs-4427	310	33	unmet	unmet	NOUN
gs-4427	310	34	medical	medical	ADJ
gs-4427	310	35	need	need	NOUN
gs-4427	310	36	.	.	PUNCT
gs-4427	311	1	hemophilia	hemophilia	PROPN
gs-4427	311	2	,	,	PUNCT
gs-4427	311	3	sickle	sickle	NOUN
gs-4427	311	4	cell	cell	NOUN
gs-4427	311	5	disease	disease	NOUN
gs-4427	311	6	,	,	PUNCT
gs-4427	311	7	and	and	CCONJ
gs-4427	311	8	spinal	spinal	ADJ
gs-4427	311	9	muscular	muscular	ADJ
gs-4427	311	10	atrophy	atrophy	NOUN
gs-4427	311	11	exemplify	exemplify	VERB
gs-4427	311	12	such	such	ADJ
gs-4427	311	13	targets	target	NOUN
gs-4427	311	14	:	:	PUNCT
gs-4427	311	15	each	each	PRON
gs-4427	311	16	involves	involve	VERB
gs-4427	311	17	a	a	DET
gs-4427	311	18	single	single	ADJ
gs-4427	311	19	well	well	ADV
gs-4427	311	20	-	-	PUNCT
gs-4427	311	21	characterized	characterize	VERB
gs-4427	311	22	genetic	genetic	ADJ
gs-4427	311	23	defect	defect	NOUN
gs-4427	311	24	,	,	PUNCT
gs-4427	311	25	has	have	AUX
gs-4427	311	26	established	establish	VERB
gs-4427	311	27	natural	natural	ADJ
gs-4427	311	28	history	history	NOUN
gs-4427	311	29	and	and	CCONJ
gs-4427	311	30	clinical	clinical	ADJ
gs-4427	311	31	outcome	outcome	NOUN
gs-4427	311	32	measures	measure	NOUN
gs-4427	311	33	,	,	PUNCT
gs-4427	311	34	affects	affect	VERB
gs-4427	311	35	tissue	tissue	NOUN
gs-4427	311	36	types	type	NOUN
gs-4427	311	37	amenable	amenable	ADJ
gs-4427	311	38	to	to	ADP
gs-4427	311	39	current	current	ADJ
gs-4427	311	40	delivery	delivery	NOUN
gs-4427	311	41	technologies	technology	NOUN
gs-4427	311	42	,	,	PUNCT
gs-4427	311	43	and	and	CCONJ
gs-4427	311	44	imposes	impose	VERB
gs-4427	311	45	substantial	substantial	ADJ
gs-4427	311	46	disease	disease	NOUN
gs-4427	311	47	burden	burden	NOUN
gs-4427	311	48	justifying	justify	VERB
gs-4427	311	49	aggressive	aggressive	ADJ
gs-4427	311	50	intervention	intervention	NOUN
gs-4427	311	51	.	.	PUNCT
gs-4427	312	1	conversely	conversely	ADV
gs-4427	312	2	,	,	PUNCT
gs-4427	312	3	several	several	ADJ
gs-4427	312	4	gene	gene	NOUN
gs-4427	312	5	therapy	therapy	NOUN
gs-4427	312	6	programs	program	NOUN
gs-4427	312	7	targeting	target	VERB
gs-4427	312	8	more	more	ADJ
gs-4427	312	9	complex	complex	ADJ
gs-4427	312	10	diseases	disease	NOUN
gs-4427	312	11	including	include	VERB
gs-4427	312	12	alzheimer	alzheimer	PROPN
gs-4427	312	13	disease	disease	NOUN
gs-4427	312	14	,	,	PUNCT
gs-4427	312	15	parkinson	parkinson	NOUN
gs-4427	312	16	disease	disease	NOUN
gs-4427	312	17	,	,	PUNCT
gs-4427	312	18	and	and	CCONJ
gs-4427	312	19	various	various	ADJ
gs-4427	312	20	solid	solid	ADJ
gs-4427	312	21	tumors	tumor	NOUN
gs-4427	312	22	have	have	AUX
gs-4427	312	23	struggled	struggle	VERB
gs-4427	312	24	to	to	PART
gs-4427	312	25	demonstrate	demonstrate	VERB
gs-4427	312	26	efficacy	efficacy	NOUN
gs-4427	312	27	,	,	PUNCT
gs-4427	312	28	potentially	potentially	ADV
gs-4427	312	29	reflecting	reflect	VERB
gs-4427	312	30	insufficient	insufficient	ADJ
gs-4427	312	31	understanding	understanding	NOUN
gs-4427	312	32	of	of	ADP
gs-4427	312	33	disease	disease	NOUN
gs-4427	312	34	mechanisms	mechanism	NOUN
gs-4427	312	35	,	,	PUNCT
gs-4427	312	36	genetic	genetic	ADJ
gs-4427	312	37	heterogeneity	heterogeneity	NOUN
gs-4427	312	38	,	,	PUNCT
gs-4427	312	39	or	or	CCONJ
gs-4427	312	40	inadequate	inadequate	ADJ
gs-4427	312	41	delivery	delivery	NOUN
gs-4427	312	42	to	to	ADP
gs-4427	312	43	affected	affected	ADJ
gs-4427	312	44	tissues	tissue	NOUN
gs-4427	312	45	.	.	PUNCT
gs-4427	313	1	the	the	DET
gs-4427	313	2	lesson	lesson	NOUN
gs-4427	313	3	appears	appear	VERB
gs-4427	313	4	to	to	PART
gs-4427	313	5	be	be	AUX
gs-4427	313	6	that	that	PRON
gs-4427	313	7	initial	initial	ADJ
gs-4427	313	8	clinical	clinical	ADJ
gs-4427	313	9	translation	translation	NOUN
gs-4427	313	10	should	should	AUX
gs-4427	313	11	focus	focus	VERB
gs-4427	313	12	on	on	ADP
gs-4427	313	13	diseases	disease	NOUN
gs-4427	313	14	where	where	SCONJ
gs-4427	313	15	target	target	NOUN
gs-4427	313	16	validation	validation	NOUN
gs-4427	313	17	is	be	AUX
gs-4427	313	18	strong	strong	ADJ
gs-4427	313	19	,	,	PUNCT
gs-4427	313	20	delivery	delivery	NOUN
gs-4427	313	21	approaches	approach	NOUN
gs-4427	313	22	are	be	AUX
gs-4427	313	23	established	establish	VERB
gs-4427	313	24	,	,	PUNCT
gs-4427	313	25	and	and	CCONJ
gs-4427	313	26	mechanisms	mechanism	NOUN
gs-4427	313	27	of	of	ADP
gs-4427	313	28	therapeutic	therapeutic	ADJ
gs-4427	313	29	benefit	benefit	NOUN
gs-4427	313	30	are	be	AUX
gs-4427	313	31	well	well	ADV
gs-4427	313	32	-	-	PUNCT
gs-4427	313	33	understood	understand	VERB
gs-4427	313	34	,	,	PUNCT
gs-4427	313	35	with	with	ADP
gs-4427	313	36	expansion	expansion	NOUN
gs-4427	313	37	to	to	ADP
gs-4427	313	38	more	more	ADV
gs-4427	313	39	complex	complex	ADJ
gs-4427	313	40	applications	application	NOUN
gs-4427	313	41	following	follow	VERB
gs-4427	313	42	proof	proof	NOUN
gs-4427	313	43	-	-	PUNCT
gs-4427	313	44	of	of	ADP
gs-4427	313	45	-	-	PUNCT
gs-4427	313	46	concept	concept	NOUN
gs-4427	313	47	success	success	NOUN
gs-4427	313	48	.	.	PUNCT
gs-4427	314	1	patient	patient	ADJ
gs-4427	314	2	selection	selection	NOUN
gs-4427	314	3	criteria	criterion	NOUN
gs-4427	314	4	profoundly	profoundly	ADV
gs-4427	314	5	influence	influence	VERB
gs-4427	314	6	clinical	clinical	ADJ
gs-4427	314	7	trial	trial	NOUN
gs-4427	314	8	outcomes	outcome	NOUN
gs-4427	314	9	and	and	CCONJ
gs-4427	314	10	product	product	NOUN
gs-4427	314	11	performance	performance	NOUN
gs-4427	314	12	,	,	PUNCT
gs-4427	314	13	yet	yet	CCONJ
gs-4427	314	14	optimal	optimal	ADJ
gs-4427	314	15	selection	selection	NOUN
gs-4427	314	16	strategies	strategy	NOUN
gs-4427	314	17	remain	remain	AUX
gs-4427	314	18	incompletely	incompletely	ADV
gs-4427	314	19	defined	define	VERB
gs-4427	314	20	for	for	ADP
gs-4427	314	21	many	many	ADJ
gs-4427	314	22	applications	application	NOUN
gs-4427	314	23	.	.	PUNCT
gs-4427	315	1	in	in	ADP
gs-4427	315	2	hemophilia	hemophilia	NOUN
gs-4427	315	3	gene	gene	NOUN
gs-4427	315	4	therapy	therapy	NOUN
gs-4427	315	5	trials	trial	NOUN
gs-4427	315	6	,	,	PUNCT
gs-4427	315	7	patients	patient	NOUN
gs-4427	315	8	with	with	ADP
gs-4427	315	9	pre	pre	ADJ
gs-4427	315	10	-	-	ADJ
gs-4427	315	11	existing	exist	VERB
gs-4427	315	12	neutralizing	neutralizing	ADJ
gs-4427	315	13	antibodies	antibody	NOUN
gs-4427	315	14	to	to	ADP
gs-4427	315	15	aav	aav	NOUN
gs-4427	315	16	vectors	vector	NOUN
gs-4427	315	17	are	be	AUX
gs-4427	315	18	excluded	exclude	VERB
gs-4427	315	19	,	,	PUNCT
gs-4427	315	20	and	and	CCONJ
gs-4427	315	21	some	some	DET
gs-4427	315	22	trials	trial	NOUN
gs-4427	315	23	further	far	ADV
gs-4427	315	24	require	require	VERB
gs-4427	315	25	absence	absence	NOUN
gs-4427	315	26	of	of	ADP
gs-4427	315	27	significant	significant	ADJ
gs-4427	315	28	liver	liver	NOUN
gs-4427	315	29	disease	disease	NOUN
gs-4427	315	30	and	and	CCONJ
gs-4427	315	31	absence	absence	NOUN
gs-4427	315	32	of	of	ADP
gs-4427	315	33	inhibitory	inhibitory	ADJ
gs-4427	315	34	antibodies	antibody	NOUN
gs-4427	315	35	to	to	ADP
gs-4427	315	36	coagulation	coagulation	NOUN
gs-4427	315	37	factors	factor	NOUN
gs-4427	315	38	.	.	PUNCT
gs-4427	316	1	these	these	DET
gs-4427	316	2	selection	selection	NOUN
gs-4427	316	3	criteria	criterion	NOUN
gs-4427	316	4	enhance	enhance	VERB
gs-4427	316	5	likelihood	likelihood	NOUN
gs-4427	316	6	of	of	ADP
gs-4427	316	7	successful	successful	ADJ
gs-4427	316	8	transduction	transduction	NOUN
gs-4427	316	9	and	and	CCONJ
gs-4427	316	10	sustained	sustained	ADJ
gs-4427	316	11	expression	expression	NOUN
gs-4427	316	12	but	but	CCONJ
gs-4427	316	13	limit	limit	VERB
gs-4427	316	14	generalizability	generalizability	NOUN
gs-4427	316	15	to	to	ADP
gs-4427	316	16	broader	broad	ADJ
gs-4427	316	17	patient	patient	ADJ
gs-4427	316	18	populations	population	NOUN
gs-4427	316	19	with	with	ADP
gs-4427	316	20	more	more	ADV
gs-4427	316	21	diverse	diverse	ADJ
gs-4427	316	22	characteristics	characteristic	NOUN
gs-4427	316	23	.	.	PUNCT
gs-4427	317	1	the	the	DET
gs-4427	317	2	tension	tension	NOUN
gs-4427	317	3	between	between	ADP
gs-4427	317	4	maximizing	maximize	VERB
gs-4427	317	5	success	success	NOUN
gs-4427	317	6	probability	probability	NOUN
gs-4427	317	7	in	in	ADP
gs-4427	317	8	early	early	ADJ
gs-4427	317	9	trials	trial	NOUN
gs-4427	317	10	through	through	ADP
gs-4427	317	11	restrictive	restrictive	ADJ
gs-4427	317	12	eligibility	eligibility	NOUN
gs-4427	317	13	and	and	CCONJ
gs-4427	317	14	demonstrating	demonstrate	VERB
gs-4427	317	15	real	real	ADJ
gs-4427	317	16	-	-	PUNCT
gs-4427	317	17	world	world	NOUN
gs-4427	317	18	effectiveness	effectiveness	NOUN
gs-4427	317	19	in	in	ADP
gs-4427	317	20	heterogeneous	heterogeneous	ADJ
gs-4427	317	21	populations	population	NOUN
gs-4427	317	22	represents	represent	VERB
gs-4427	317	23	an	an	DET
gs-4427	317	24	ongoing	ongoing	ADJ
gs-4427	317	25	challenge	challenge	NOUN
gs-4427	317	26	.	.	PUNCT
gs-4427	318	1	post	post	ADJ
gs-4427	318	2	-	-	ADJ
gs-4427	318	3	approval	approval	ADJ
gs-4427	318	4	expansion	expansion	NOUN
gs-4427	318	5	of	of	ADP
gs-4427	318	6	eligibility	eligibility	NOUN
gs-4427	318	7	criteria	criterion	NOUN
gs-4427	318	8	based	base	VERB
gs-4427	318	9	on	on	ADP
gs-4427	318	10	accumulating	accumulate	VERB
gs-4427	318	11	safety	safety	NOUN
gs-4427	318	12	data	datum	NOUN
gs-4427	318	13	may	may	AUX
gs-4427	318	14	enable	enable	VERB
gs-4427	318	15	treatment	treatment	NOUN
gs-4427	318	16	of	of	ADP
gs-4427	318	17	broader	broad	ADJ
gs-4427	318	18	populations	population	NOUN
gs-4427	318	19	,	,	PUNCT
gs-4427	318	20	though	though	SCONJ
gs-4427	318	21	conservative	conservative	ADJ
gs-4427	318	22	initial	initial	ADJ
gs-4427	318	23	eligibility	eligibility	NOUN
gs-4427	318	24	likely	likely	ADV
gs-4427	318	25	remains	remain	VERB
gs-4427	318	26	appropriate	appropriate	ADJ
gs-4427	318	27	given	give	VERB
gs-4427	318	28	uncertainties	uncertainty	NOUN
gs-4427	318	29	.	.	PUNCT
gs-4427	319	1	several	several	ADJ
gs-4427	319	2	critical	critical	ADJ
gs-4427	319	3	questions	question	NOUN
gs-4427	319	4	remain	remain	AUX
gs-4427	319	5	incompletely	incompletely	ADV
gs-4427	319	6	answered	answer	VERB
gs-4427	319	7	despite	despite	SCONJ
gs-4427	319	8	substantial	substantial	ADJ
gs-4427	319	9	clinical	clinical	ADJ
gs-4427	319	10	experience	experience	NOUN
gs-4427	319	11	.	.	PUNCT
gs-4427	320	1	the	the	DET
gs-4427	320	2	long	long	ADJ
gs-4427	320	3	-	-	PUNCT
gs-4427	320	4	term	term	NOUN
gs-4427	320	5	durability	durability	NOUN
gs-4427	320	6	of	of	ADP
gs-4427	320	7	therapeutic	therapeutic	ADJ
gs-4427	320	8	benefit	benefit	NOUN
gs-4427	320	9	beyond	beyond	ADP
gs-4427	320	10	current	current	ADJ
gs-4427	320	11	follow	follow	NOUN
gs-4427	320	12	-	-	PUNCT
gs-4427	320	13	up	up	ADP
gs-4427	320	14	durations	duration	NOUN
gs-4427	320	15	remains	remain	VERB
gs-4427	320	16	uncertain	uncertain	ADJ
gs-4427	320	17	for	for	ADP
gs-4427	320	18	most	most	ADJ
gs-4427	320	19	gene	gene	NOUN
gs-4427	320	20	therapies	therapy	NOUN
gs-4427	320	21	,	,	PUNCT
gs-4427	320	22	with	with	ADP
gs-4427	320	23	few	few	ADJ
gs-4427	320	24	products	product	NOUN
gs-4427	320	25	having	have	VERB
gs-4427	320	26	more	more	ADJ
gs-4427	320	27	than	than	ADP
gs-4427	320	28	5	5	NUM
gs-4427	320	29	-	-	SYM
gs-4427	320	30	10	10	NUM
gs-4427	320	31	years	year	NOUN
gs-4427	320	32	of	of	ADP
gs-4427	320	33	follow	follow	VERB
gs-4427	320	34	-	-	PUNCT
gs-4427	320	35	up	up	ADP
gs-4427	320	36	data	datum	NOUN
gs-4427	320	37	.	.	PUNCT
gs-4427	321	1	while	while	SCONJ
gs-4427	321	2	current	current	ADJ
gs-4427	321	3	data	datum	NOUN
gs-4427	321	4	suggest	suggest	VERB
gs-4427	321	5	sustained	sustain	VERB
gs-4427	321	6	benefit	benefit	NOUN
gs-4427	321	7	for	for	ADP
gs-4427	321	8	many	many	ADJ
gs-4427	321	9	georgian	georgian	NOUN
gs-4427	321	10	scientists/	scientists/	NUM
gs-4427	321	11	.	.	PUNCT
gs-4427	322	1	7	7	NUM
gs-4427	322	2	n	n	DET
gs-4427	322	3	4	4	NUM
gs-4427	322	4	,	,	PUNCT
gs-4427	322	5	2025	2025	NUM
gs-4427	322	6	651	651	NUM
gs-4427	322	7	applications	application	NOUN
gs-4427	322	8	,	,	PUNCT
gs-4427	322	9	the	the	DET
gs-4427	322	10	possibility	possibility	NOUN
gs-4427	322	11	of	of	ADP
gs-4427	322	12	late	late	ADJ
gs-4427	322	13	transgene	transgene	ADJ
gs-4427	322	14	expression	expression	NOUN
gs-4427	322	15	loss	loss	NOUN
gs-4427	322	16	,	,	PUNCT
gs-4427	322	17	development	development	NOUN
gs-4427	322	18	of	of	ADP
gs-4427	322	19	delayed	delay	VERB
gs-4427	322	20	immune	immune	ADJ
gs-4427	322	21	responses	response	NOUN
gs-4427	322	22	,	,	PUNCT
gs-4427	322	23	or	or	CCONJ
gs-4427	322	24	age	age	NOUN
gs-4427	322	25	-	-	PUNCT
gs-4427	322	26	related	relate	VERB
gs-4427	322	27	changes	change	NOUN
gs-4427	322	28	affecting	affect	VERB
gs-4427	322	29	transduced	transduce	VERB
gs-4427	322	30	cell	cell	NOUN
gs-4427	322	31	populations	population	NOUN
gs-4427	322	32	necessitates	necessitate	VERB
gs-4427	322	33	continued	continued	ADJ
gs-4427	322	34	monitoring	monitoring	NOUN
gs-4427	322	35	.	.	PUNCT
gs-4427	323	1	the	the	DET
gs-4427	323	2	optimal	optimal	ADJ
gs-4427	323	3	timing	timing	NOUN
gs-4427	323	4	of	of	ADP
gs-4427	323	5	gene	gene	NOUN
gs-4427	323	6	therapy	therapy	NOUN
gs-4427	323	7	intervention	intervention	NOUN
gs-4427	323	8	—	—	PUNCT
gs-4427	323	9	whether	whether	SCONJ
gs-4427	323	10	early	early	ADJ
gs-4427	323	11	in	in	ADP
gs-4427	323	12	disease	disease	NOUN
gs-4427	323	13	course	course	NOUN
gs-4427	323	14	before	before	SCONJ
gs-4427	323	15	irreversible	irreversible	ADJ
gs-4427	323	16	organ	organ	NOUN
gs-4427	323	17	damage	damage	NOUN
gs-4427	323	18	accumulates	accumulate	VERB
gs-4427	323	19	or	or	CCONJ
gs-4427	323	20	later	later	ADV
gs-4427	323	21	after	after	ADP
gs-4427	323	22	establishing	establish	VERB
gs-4427	323	23	severity	severity	NOUN
gs-4427	323	24	warranting	warrant	VERB
gs-4427	323	25	aggressive	aggressive	ADJ
gs-4427	323	26	intervention	intervention	NOUN
gs-4427	323	27	—	—	PUNCT
gs-4427	323	28	remains	remain	VERB
gs-4427	323	29	debated	debate	VERB
gs-4427	323	30	for	for	ADP
gs-4427	323	31	many	many	ADJ
gs-4427	323	32	conditions	condition	NOUN
gs-4427	323	33	.	.	PUNCT
gs-4427	324	1	biomarkers	biomarker	NOUN
gs-4427	324	2	predicting	predict	VERB
gs-4427	324	3	treatment	treatment	NOUN
gs-4427	324	4	response	response	NOUN
gs-4427	324	5	would	would	AUX
gs-4427	324	6	enable	enable	VERB
gs-4427	324	7	more	more	ADJ
gs-4427	324	8	personalized	personalized	ADJ
gs-4427	324	9	patient	patient	ADJ
gs-4427	324	10	selection	selection	NOUN
gs-4427	324	11	and	and	CCONJ
gs-4427	324	12	potentially	potentially	ADV
gs-4427	324	13	improve	improve	VERB
gs-4427	324	14	outcomes	outcome	NOUN
gs-4427	324	15	by	by	ADP
gs-4427	324	16	identifying	identify	VERB
gs-4427	324	17	individuals	individual	NOUN
gs-4427	324	18	most	most	ADV
gs-4427	324	19	likely	likely	ADJ
gs-4427	324	20	to	to	PART
gs-4427	324	21	benefit	benefit	VERB
gs-4427	324	22	,	,	PUNCT
gs-4427	324	23	but	but	CCONJ
gs-4427	324	24	such	such	ADJ
gs-4427	324	25	markers	marker	NOUN
gs-4427	324	26	remain	remain	VERB
gs-4427	324	27	elusive	elusive	ADJ
gs-4427	324	28	for	for	ADP
gs-4427	324	29	most	most	ADJ
gs-4427	324	30	applications	application	NOUN
gs-4427	324	31	.	.	PUNCT
gs-4427	325	1	the	the	DET
gs-4427	325	2	potential	potential	NOUN
gs-4427	325	3	for	for	ADP
gs-4427	325	4	germline	germline	NOUN
gs-4427	325	5	transmission	transmission	NOUN
gs-4427	325	6	of	of	ADP
gs-4427	325	7	editing	edit	VERB
gs-4427	325	8	modifications	modification	NOUN
gs-4427	325	9	or	or	CCONJ
gs-4427	325	10	integration	integration	NOUN
gs-4427	325	11	events	event	NOUN
gs-4427	325	12	,	,	PUNCT
gs-4427	325	13	while	while	SCONJ
gs-4427	325	14	expected	expect	VERB
gs-4427	325	15	to	to	PART
gs-4427	325	16	be	be	AUX
gs-4427	325	17	extremely	extremely	ADV
gs-4427	325	18	rare	rare	ADJ
gs-4427	325	19	,	,	PUNCT
gs-4427	325	20	requires	require	VERB
gs-4427	325	21	ongoing	ongoing	ADJ
gs-4427	325	22	assessment	assessment	NOUN
gs-4427	325	23	and	and	CCONJ
gs-4427	325	24	has	have	VERB
gs-4427	325	25	implications	implication	NOUN
gs-4427	325	26	for	for	ADP
gs-4427	325	27	genetic	genetic	ADJ
gs-4427	325	28	counseling	counseling	NOUN
gs-4427	325	29	and	and	CCONJ
gs-4427	325	30	family	family	NOUN
gs-4427	325	31	planning	planning	NOUN
gs-4427	325	32	discussions	discussion	NOUN
gs-4427	325	33	with	with	ADP
gs-4427	325	34	treated	treat	VERB
gs-4427	325	35	patients	patient	NOUN
gs-4427	325	36	.	.	PUNCT
gs-4427	326	1	conclusions	conclusion	NOUN
gs-4427	326	2	gene	gene	NOUN
gs-4427	326	3	therapy	therapy	NOUN
gs-4427	326	4	has	have	AUX
gs-4427	326	5	unequivocally	unequivocally	ADV
gs-4427	326	6	transitioned	transition	VERB
gs-4427	326	7	from	from	ADP
gs-4427	326	8	an	an	DET
gs-4427	326	9	experimental	experimental	ADJ
gs-4427	326	10	concept	concept	NOUN
gs-4427	326	11	to	to	ADP
gs-4427	326	12	a	a	DET
gs-4427	326	13	clinically	clinically	ADV
gs-4427	326	14	validated	validate	VERB
gs-4427	326	15	and	and	CCONJ
gs-4427	326	16	transformative	transformative	ADJ
gs-4427	326	17	therapeutic	therapeutic	ADJ
gs-4427	326	18	paradigm	paradigm	NOUN
gs-4427	326	19	,	,	PUNCT
gs-4427	326	20	fundamentally	fundamentally	ADV
gs-4427	326	21	reshaping	reshape	VERB
gs-4427	326	22	modern	modern	ADJ
gs-4427	326	23	medicine	medicine	NOUN
gs-4427	326	24	’s	’s	PART
gs-4427	326	25	approach	approach	NOUN
gs-4427	326	26	to	to	ADP
gs-4427	326	27	disease	disease	NOUN
gs-4427	326	28	management	management	NOUN
gs-4427	326	29	.	.	PUNCT
gs-4427	327	1	the	the	DET
gs-4427	327	2	cumulative	cumulative	ADJ
gs-4427	327	3	evidence	evidence	NOUN
gs-4427	327	4	reviewed	review	VERB
gs-4427	327	5	in	in	ADP
gs-4427	327	6	this	this	DET
gs-4427	327	7	work	work	NOUN
gs-4427	327	8	demonstrates	demonstrate	VERB
gs-4427	327	9	that	that	SCONJ
gs-4427	327	10	advances	advance	NOUN
gs-4427	327	11	in	in	ADP
gs-4427	327	12	viral	viral	ADJ
gs-4427	327	13	vector	vector	NOUN
gs-4427	327	14	engineering	engineering	NOUN
gs-4427	327	15	,	,	PUNCT
gs-4427	327	16	genome	genome	NOUN
gs-4427	327	17	editing	editing	NOUN
gs-4427	327	18	technologies	technology	NOUN
gs-4427	327	19	,	,	PUNCT
gs-4427	327	20	and	and	CCONJ
gs-4427	327	21	cell	cell	NOUN
gs-4427	327	22	-	-	PUNCT
gs-4427	327	23	based	base	VERB
gs-4427	327	24	genetic	genetic	ADJ
gs-4427	327	25	interventions	intervention	NOUN
gs-4427	327	26	have	have	AUX
gs-4427	327	27	enabled	enable	VERB
gs-4427	327	28	durable	durable	ADJ
gs-4427	327	29	,	,	PUNCT
gs-4427	327	30	and	and	CCONJ
gs-4427	327	31	in	in	ADP
gs-4427	327	32	some	some	DET
gs-4427	327	33	cases	case	NOUN
gs-4427	327	34	curative	curative	ADJ
gs-4427	327	35	,	,	PUNCT
gs-4427	327	36	outcomes	outcome	NOUN
gs-4427	327	37	across	across	ADP
gs-4427	327	38	a	a	DET
gs-4427	327	39	spectrum	spectrum	NOUN
gs-4427	327	40	of	of	ADP
gs-4427	327	41	inherited	inherit	VERB
gs-4427	327	42	and	and	CCONJ
gs-4427	327	43	acquired	acquire	VERB
gs-4427	327	44	diseases	disease	NOUN
gs-4427	327	45	.	.	PUNCT
gs-4427	328	1	the	the	DET
gs-4427	328	2	successful	successful	ADJ
gs-4427	328	3	clinical	clinical	ADJ
gs-4427	328	4	implementation	implementation	NOUN
gs-4427	328	5	of	of	ADP
gs-4427	328	6	adeno	adeno	NOUN
gs-4427	328	7	-	-	PUNCT
gs-4427	328	8	associated	associate	VERB
gs-4427	328	9	virus	virus	NOUN
gs-4427	328	10	–	–	PUNCT
gs-4427	328	11	based	base	VERB
gs-4427	328	12	therapies	therapy	NOUN
gs-4427	328	13	,	,	PUNCT
gs-4427	328	14	lentiviral	lentiviral	ADJ
gs-4427	328	15	ex	ex	X
gs-4427	328	16	vivo	vivo	NOUN
gs-4427	328	17	gene	gene	NOUN
gs-4427	328	18	correction	correction	NOUN
gs-4427	328	19	,	,	PUNCT
gs-4427	328	20	and	and	CCONJ
gs-4427	328	21	crispr	crispr	NOUN
gs-4427	328	22	-	-	PUNCT
gs-4427	328	23	cas	cas	ADJ
gs-4427	328	24	–	–	PUNCT
gs-4427	328	25	mediated	mediate	VERB
gs-4427	328	26	genome	genome	NOUN
gs-4427	328	27	editing	editing	NOUN
gs-4427	328	28	underscores	underscore	VERB
gs-4427	328	29	the	the	DET
gs-4427	328	30	maturation	maturation	NOUN
gs-4427	328	31	of	of	ADP
gs-4427	328	32	the	the	DET
gs-4427	328	33	field	field	NOUN
gs-4427	328	34	and	and	CCONJ
gs-4427	328	35	validates	validate	VERB
gs-4427	328	36	decades	decade	NOUN
gs-4427	328	37	of	of	ADP
gs-4427	328	38	foundational	foundational	ADJ
gs-4427	328	39	molecular	molecular	ADJ
gs-4427	328	40	and	and	CCONJ
gs-4427	328	41	translational	translational	ADJ
gs-4427	328	42	research	research	NOUN
gs-4427	328	43	.	.	PUNCT
gs-4427	329	1	the	the	DET
gs-4427	329	2	renaissance	renaissance	NOUN
gs-4427	329	3	of	of	ADP
gs-4427	329	4	gene	gene	NOUN
gs-4427	329	5	therapy	therapy	NOUN
gs-4427	329	6	has	have	AUX
gs-4427	329	7	been	be	AUX
gs-4427	329	8	driven	drive	VERB
gs-4427	329	9	by	by	ADP
gs-4427	329	10	technological	technological	ADJ
gs-4427	329	11	breakthroughs	breakthrough	NOUN
gs-4427	329	12	that	that	PRON
gs-4427	329	13	addressed	address	VERB
gs-4427	329	14	earlier	early	ADJ
gs-4427	329	15	limitations	limitation	NOUN
gs-4427	329	16	related	relate	VERB
gs-4427	329	17	to	to	ADP
gs-4427	329	18	safety	safety	NOUN
gs-4427	329	19	,	,	PUNCT
gs-4427	329	20	delivery	delivery	NOUN
gs-4427	329	21	efficiency	efficiency	NOUN
gs-4427	329	22	,	,	PUNCT
gs-4427	329	23	and	and	CCONJ
gs-4427	329	24	durability	durability	NOUN
gs-4427	329	25	of	of	ADP
gs-4427	329	26	gene	gene	NOUN
gs-4427	329	27	expression	expression	NOUN
gs-4427	329	28	.	.	PUNCT
gs-4427	330	1	the	the	DET
gs-4427	330	2	refinement	refinement	NOUN
gs-4427	330	3	of	of	ADP
gs-4427	330	4	aav	aav	NOUN
gs-4427	330	5	and	and	CCONJ
gs-4427	330	6	lentiviral	lentiviral	ADJ
gs-4427	330	7	platforms	platform	NOUN
gs-4427	330	8	has	have	AUX
gs-4427	330	9	enabled	enable	VERB
gs-4427	330	10	targeted	target	VERB
gs-4427	330	11	and	and	CCONJ
gs-4427	330	12	sustained	sustain	VERB
gs-4427	330	13	genetic	genetic	ADJ
gs-4427	330	14	modification	modification	NOUN
gs-4427	330	15	with	with	ADP
gs-4427	330	16	acceptable	acceptable	ADJ
gs-4427	330	17	risk	risk	NOUN
gs-4427	330	18	profiles	profile	NOUN
gs-4427	330	19	,	,	PUNCT
gs-4427	330	20	while	while	SCONJ
gs-4427	330	21	genome	genome	NOUN
gs-4427	330	22	editing	editing	NOUN
gs-4427	330	23	technologies	technology	NOUN
gs-4427	330	24	have	have	AUX
gs-4427	330	25	expanded	expand	VERB
gs-4427	330	26	therapeutic	therapeutic	ADJ
gs-4427	330	27	possibilities	possibility	NOUN
gs-4427	330	28	beyond	beyond	ADP
gs-4427	330	29	gene	gene	NOUN
gs-4427	330	30	replacement	replacement	NOUN
gs-4427	330	31	toward	toward	ADP
gs-4427	330	32	precise	precise	ADJ
gs-4427	330	33	correction	correction	NOUN
gs-4427	330	34	of	of	ADP
gs-4427	330	35	pathogenic	pathogenic	ADJ
gs-4427	330	36	mutations	mutation	NOUN
gs-4427	330	37	.	.	PUNCT
gs-4427	331	1	the	the	DET
gs-4427	331	2	approval	approval	NOUN
gs-4427	331	3	of	of	ADP
gs-4427	331	4	crispr	crispr	NOUN
gs-4427	331	5	-	-	PUNCT
gs-4427	331	6	based	base	VERB
gs-4427	331	7	therapies	therapy	NOUN
gs-4427	331	8	and	and	CCONJ
gs-4427	331	9	the	the	DET
gs-4427	331	10	rapid	rapid	ADJ
gs-4427	331	11	clinical	clinical	ADJ
gs-4427	331	12	translation	translation	NOUN
gs-4427	331	13	of	of	ADP
gs-4427	331	14	engineered	engineer	VERB
gs-4427	331	15	cell	cell	NOUN
gs-4427	331	16	therapies	therapy	NOUN
gs-4427	331	17	,	,	PUNCT
gs-4427	331	18	particularly	particularly	ADV
gs-4427	331	19	car	car	NOUN
gs-4427	331	20	-	-	PUNCT
gs-4427	331	21	t	t	NOUN
gs-4427	331	22	cells	cell	NOUN
gs-4427	331	23	,	,	PUNCT
gs-4427	331	24	represent	represent	VERB
gs-4427	331	25	historic	historic	ADJ
gs-4427	331	26	milestones	milestone	NOUN
gs-4427	331	27	demonstrating	demonstrate	VERB
gs-4427	331	28	that	that	SCONJ
gs-4427	331	29	genetic	genetic	ADJ
gs-4427	331	30	medicine	medicine	NOUN
gs-4427	331	31	can	can	AUX
gs-4427	331	32	deliver	deliver	VERB
gs-4427	331	33	durable	durable	ADJ
gs-4427	331	34	clinical	clinical	ADJ
gs-4427	331	35	benefit	benefit	NOUN
gs-4427	331	36	even	even	ADV
gs-4427	331	37	in	in	ADP
gs-4427	331	38	diseases	disease	NOUN
gs-4427	331	39	previously	previously	ADV
gs-4427	331	40	considered	consider	VERB
gs-4427	331	41	incurable	incurable	ADJ
gs-4427	331	42	.	.	PUNCT
gs-4427	332	1	at	at	ADP
gs-4427	332	2	the	the	DET
gs-4427	332	3	same	same	ADJ
gs-4427	332	4	time	time	NOUN
gs-4427	332	5	,	,	PUNCT
gs-4427	332	6	the	the	DET
gs-4427	332	7	expansion	expansion	NOUN
gs-4427	332	8	of	of	ADP
gs-4427	332	9	gene	gene	NOUN
gs-4427	332	10	therapy	therapy	NOUN
gs-4427	332	11	into	into	ADP
gs-4427	332	12	broader	broad	ADJ
gs-4427	332	13	and	and	CCONJ
gs-4427	332	14	more	more	ADV
gs-4427	332	15	complex	complex	ADJ
gs-4427	332	16	disease	disease	NOUN
gs-4427	332	17	indications	indication	NOUN
gs-4427	332	18	has	have	AUX
gs-4427	332	19	illuminated	illuminate	VERB
gs-4427	332	20	persistent	persistent	ADJ
gs-4427	332	21	scientific	scientific	ADJ
gs-4427	332	22	,	,	PUNCT
gs-4427	332	23	clinical	clinical	ADJ
gs-4427	332	24	,	,	PUNCT
gs-4427	332	25	and	and	CCONJ
gs-4427	332	26	systemic	systemic	ADJ
gs-4427	332	27	challenges	challenge	NOUN
gs-4427	332	28	.	.	PUNCT
gs-4427	333	1	immunogenicity	immunogenicity	NOUN
gs-4427	333	2	,	,	PUNCT
gs-4427	333	3	manufacturing	manufacturing	NOUN
gs-4427	333	4	scalability	scalability	NOUN
gs-4427	333	5	,	,	PUNCT
gs-4427	333	6	long	long	ADJ
gs-4427	333	7	-	-	PUNCT
gs-4427	333	8	term	term	NOUN
gs-4427	333	9	safety	safety	NOUN
gs-4427	333	10	surveillance	surveillance	NOUN
gs-4427	333	11	,	,	PUNCT
gs-4427	333	12	and	and	CCONJ
gs-4427	333	13	economic	economic	ADJ
gs-4427	333	14	sustainability	sustainability	NOUN
gs-4427	333	15	remain	remain	VERB
gs-4427	333	16	critical	critical	ADJ
gs-4427	333	17	determinants	determinant	NOUN
gs-4427	333	18	of	of	ADP
gs-4427	333	19	therapeutic	therapeutic	ADJ
gs-4427	333	20	success	success	NOUN
gs-4427	333	21	and	and	CCONJ
gs-4427	333	22	equitable	equitable	ADJ
gs-4427	333	23	access	access	NOUN
gs-4427	333	24	.	.	PUNCT
gs-4427	334	1	the	the	DET
gs-4427	334	2	high	high	ADJ
gs-4427	334	3	upfront	upfront	ADJ
gs-4427	334	4	costs	cost	NOUN
gs-4427	334	5	of	of	ADP
gs-4427	334	6	approved	approve	VERB
gs-4427	334	7	gene	gene	NOUN
gs-4427	334	8	therapies	therapy	NOUN
gs-4427	334	9	,	,	PUNCT
gs-4427	334	10	while	while	SCONJ
gs-4427	334	11	often	often	ADV
gs-4427	334	12	justified	justify	VERB
gs-4427	334	13	by	by	ADP
gs-4427	334	14	long	long	ADJ
gs-4427	334	15	-	-	PUNCT
gs-4427	334	16	term	term	NOUN
gs-4427	334	17	clinical	clinical	ADJ
gs-4427	334	18	value	value	NOUN
gs-4427	334	19	,	,	PUNCT
gs-4427	334	20	pose	pose	VERB
gs-4427	334	21	significant	significant	ADJ
gs-4427	334	22	challenges	challenge	NOUN
gs-4427	334	23	for	for	ADP
gs-4427	334	24	healthcare	healthcare	NOUN
gs-4427	334	25	systems	system	NOUN
gs-4427	334	26	and	and	CCONJ
gs-4427	334	27	necessitate	necessitate	ADJ
gs-4427	334	28	innovative	innovative	ADJ
gs-4427	334	29	reimbursement	reimbursement	NOUN
gs-4427	334	30	and	and	CCONJ
gs-4427	334	31	policy	policy	NOUN
gs-4427	334	32	frameworks	framework	NOUN
gs-4427	334	33	.	.	PUNCT
gs-4427	335	1	furthermore	furthermore	ADV
gs-4427	335	2	,	,	PUNCT
gs-4427	335	3	uncertainties	uncertainty	NOUN
gs-4427	335	4	regarding	regard	VERB
gs-4427	335	5	long	long	ADJ
gs-4427	335	6	-	-	PUNCT
gs-4427	335	7	term	term	NOUN
gs-4427	335	8	georgian	georgian	NOUN
gs-4427	335	9	scientists/	scientists/	NUM
gs-4427	335	10	.	.	PUNCT
gs-4427	336	1	7	7	NUM
gs-4427	336	2	n	n	DET
gs-4427	336	3	4	4	NUM
gs-4427	336	4	,	,	PUNCT
gs-4427	336	5	2025	2025	NUM
gs-4427	336	6	652	652	NUM
gs-4427	336	7	durability	durability	NOUN
gs-4427	336	8	,	,	PUNCT
gs-4427	336	9	re	re	VERB
gs-4427	336	10	-	-	VERB
gs-4427	336	11	dosing	dose	VERB
gs-4427	336	12	feasibility	feasibility	NOUN
gs-4427	336	13	,	,	PUNCT
gs-4427	336	14	and	and	CCONJ
gs-4427	336	15	late	late	ADV
gs-4427	336	16	-	-	PUNCT
gs-4427	336	17	emerging	emerge	VERB
gs-4427	336	18	risks	risk	NOUN
gs-4427	336	19	emphasize	emphasize	VERB
gs-4427	336	20	the	the	DET
gs-4427	336	21	need	need	NOUN
gs-4427	336	22	for	for	ADP
gs-4427	336	23	continued	continue	VERB
gs-4427	336	24	vigilance	vigilance	NOUN
gs-4427	336	25	and	and	CCONJ
gs-4427	336	26	robust	robust	ADJ
gs-4427	336	27	post	post	ADJ
gs-4427	336	28	-	-	ADJ
gs-4427	336	29	marketing	marketing	ADJ
gs-4427	336	30	surveillance	surveillance	NOUN
gs-4427	336	31	.	.	PUNCT
gs-4427	337	1	importantly	importantly	ADV
gs-4427	337	2	,	,	PUNCT
gs-4427	337	3	this	this	DET
gs-4427	337	4	study	study	NOUN
gs-4427	337	5	highlights	highlight	NOUN
gs-4427	337	6	that	that	PRON
gs-4427	337	7	gene	gene	NOUN
gs-4427	337	8	therapy	therapy	NOUN
gs-4427	337	9	is	be	AUX
gs-4427	337	10	no	no	ADV
gs-4427	337	11	longer	long	ADV
gs-4427	337	12	a	a	DET
gs-4427	337	13	singular	singular	ADJ
gs-4427	337	14	technology	technology	NOUN
gs-4427	337	15	but	but	CCONJ
gs-4427	337	16	rather	rather	ADV
gs-4427	337	17	a	a	DET
gs-4427	337	18	diverse	diverse	ADJ
gs-4427	337	19	ecosystem	ecosystem	NOUN
gs-4427	337	20	of	of	ADP
gs-4427	337	21	platforms	platform	NOUN
gs-4427	337	22	,	,	PUNCT
gs-4427	337	23	each	each	PRON
gs-4427	337	24	with	with	ADP
gs-4427	337	25	distinct	distinct	ADJ
gs-4427	337	26	advantages	advantage	NOUN
gs-4427	337	27	,	,	PUNCT
gs-4427	337	28	limitations	limitation	NOUN
gs-4427	337	29	,	,	PUNCT
gs-4427	337	30	and	and	CCONJ
gs-4427	337	31	optimal	optimal	ADJ
gs-4427	337	32	applications	application	NOUN
gs-4427	337	33	.	.	PUNCT
gs-4427	338	1	the	the	DET
gs-4427	338	2	future	future	NOUN
gs-4427	338	3	of	of	ADP
gs-4427	338	4	the	the	DET
gs-4427	338	5	field	field	NOUN
gs-4427	338	6	lies	lie	VERB
gs-4427	338	7	not	not	PART
gs-4427	338	8	only	only	ADV
gs-4427	338	9	in	in	ADP
gs-4427	338	10	further	further	ADJ
gs-4427	338	11	refinement	refinement	NOUN
gs-4427	338	12	of	of	ADP
gs-4427	338	13	individual	individual	ADJ
gs-4427	338	14	technologies	technology	NOUN
gs-4427	338	15	but	but	CCONJ
gs-4427	338	16	also	also	ADV
gs-4427	338	17	in	in	ADP
gs-4427	338	18	their	their	PRON
gs-4427	338	19	strategic	strategic	ADJ
gs-4427	338	20	integration	integration	NOUN
gs-4427	338	21	,	,	PUNCT
gs-4427	338	22	combining	combine	VERB
gs-4427	338	23	delivery	delivery	NOUN
gs-4427	338	24	systems	system	NOUN
gs-4427	338	25	,	,	PUNCT
gs-4427	338	26	editing	edit	VERB
gs-4427	338	27	modalities	modality	NOUN
gs-4427	338	28	,	,	PUNCT
gs-4427	338	29	and	and	CCONJ
gs-4427	338	30	regulatory	regulatory	ADJ
gs-4427	338	31	innovations	innovation	NOUN
gs-4427	338	32	to	to	PART
gs-4427	338	33	maximize	maximize	VERB
gs-4427	338	34	therapeutic	therapeutic	ADJ
gs-4427	338	35	benefit	benefit	NOUN
gs-4427	338	36	while	while	SCONJ
gs-4427	338	37	minimizing	minimize	VERB
gs-4427	338	38	risk	risk	NOUN
gs-4427	338	39	.	.	PUNCT
gs-4427	339	1	as	as	SCONJ
gs-4427	339	2	gene	gene	NOUN
gs-4427	339	3	therapy	therapy	NOUN
gs-4427	339	4	continues	continue	VERB
gs-4427	339	5	to	to	PART
gs-4427	339	6	evolve	evolve	VERB
gs-4427	339	7	,	,	PUNCT
gs-4427	339	8	its	its	PRON
gs-4427	339	9	successful	successful	ADJ
gs-4427	339	10	integration	integration	NOUN
gs-4427	339	11	into	into	ADP
gs-4427	339	12	routine	routine	ADJ
gs-4427	339	13	clinical	clinical	ADJ
gs-4427	339	14	practice	practice	NOUN
gs-4427	339	15	will	will	AUX
gs-4427	339	16	depend	depend	VERB
gs-4427	339	17	on	on	ADP
gs-4427	339	18	multidisciplinary	multidisciplinary	ADJ
gs-4427	339	19	collaboration	collaboration	NOUN
gs-4427	339	20	,	,	PUNCT
gs-4427	339	21	continued	continue	VERB
gs-4427	339	22	scientific	scientific	ADJ
gs-4427	339	23	innovation	innovation	NOUN
gs-4427	339	24	,	,	PUNCT
gs-4427	339	25	ethical	ethical	ADJ
gs-4427	339	26	stewardship	stewardship	NOUN
gs-4427	339	27	,	,	PUNCT
gs-4427	339	28	and	and	CCONJ
gs-4427	339	29	health	health	NOUN
gs-4427	339	30	system	system	NOUN
gs-4427	339	31	adaptation	adaptation	NOUN
gs-4427	339	32	.	.	PUNCT
gs-4427	340	1	recommendations	recommendation	NOUN
gs-4427	340	2	future	future	ADJ
gs-4427	340	3	research	research	NOUN
gs-4427	340	4	efforts	effort	NOUN
gs-4427	340	5	should	should	AUX
gs-4427	340	6	prioritize	prioritize	VERB
gs-4427	340	7	the	the	DET
gs-4427	340	8	development	development	NOUN
gs-4427	340	9	of	of	ADP
gs-4427	340	10	next	next	ADJ
gs-4427	340	11	-	-	PUNCT
gs-4427	340	12	generation	generation	NOUN
gs-4427	340	13	gene	gene	NOUN
gs-4427	340	14	delivery	delivery	NOUN
gs-4427	340	15	and	and	CCONJ
gs-4427	340	16	genome	genome	NOUN
gs-4427	340	17	editing	editing	NOUN
gs-4427	340	18	technologies	technology	NOUN
gs-4427	340	19	that	that	PRON
gs-4427	340	20	enhance	enhance	VERB
gs-4427	340	21	precision	precision	NOUN
gs-4427	340	22	,	,	PUNCT
gs-4427	340	23	reduce	reduce	VERB
gs-4427	340	24	immunogenicity	immunogenicity	NOUN
gs-4427	340	25	,	,	PUNCT
gs-4427	340	26	and	and	CCONJ
gs-4427	340	27	enable	enable	VERB
gs-4427	340	28	safe	safe	ADJ
gs-4427	340	29	re	re	NOUN
gs-4427	340	30	-	-	VERB
gs-4427	340	31	dosing	dose	VERB
gs-4427	340	32	where	where	SCONJ
gs-4427	340	33	clinically	clinically	ADV
gs-4427	340	34	necessary	necessary	ADJ
gs-4427	340	35	.	.	PUNCT
gs-4427	341	1	continued	continue	VERB
gs-4427	341	2	optimization	optimization	NOUN
gs-4427	341	3	of	of	ADP
gs-4427	341	4	base	base	NOUN
gs-4427	341	5	editing	editing	NOUN
gs-4427	341	6	and	and	CCONJ
gs-4427	341	7	prime	prime	ADJ
gs-4427	341	8	editing	editing	NOUN
gs-4427	341	9	platforms	platform	NOUN
gs-4427	341	10	is	be	AUX
gs-4427	341	11	particularly	particularly	ADV
gs-4427	341	12	recommended	recommend	VERB
gs-4427	341	13	,	,	PUNCT
gs-4427	341	14	as	as	SCONJ
gs-4427	341	15	these	these	DET
gs-4427	341	16	approaches	approach	NOUN
gs-4427	341	17	offer	offer	VERB
gs-4427	341	18	the	the	DET
gs-4427	341	19	potential	potential	NOUN
gs-4427	341	20	to	to	PART
gs-4427	341	21	correct	correct	VERB
gs-4427	341	22	pathogenic	pathogenic	ADJ
gs-4427	341	23	mutations	mutation	NOUN
gs-4427	341	24	without	without	ADP
gs-4427	341	25	inducing	induce	VERB
gs-4427	341	26	double	double	ADJ
gs-4427	341	27	-	-	PUNCT
gs-4427	341	28	strand	strand	NOUN
gs-4427	341	29	dna	dna	NOUN
gs-4427	341	30	breaks	break	NOUN
gs-4427	341	31	,	,	PUNCT
gs-4427	341	32	thereby	thereby	ADV
gs-4427	341	33	improving	improve	VERB
gs-4427	341	34	safety	safety	NOUN
gs-4427	341	35	profiles	profile	NOUN
gs-4427	341	36	and	and	CCONJ
gs-4427	341	37	expanding	expand	VERB
gs-4427	341	38	applicability	applicability	NOUN
gs-4427	341	39	to	to	ADP
gs-4427	341	40	a	a	DET
gs-4427	341	41	wider	wide	ADJ
gs-4427	341	42	range	range	NOUN
gs-4427	341	43	of	of	ADP
gs-4427	341	44	genetic	genetic	ADJ
gs-4427	341	45	disorders	disorder	NOUN
gs-4427	341	46	.	.	PUNCT
gs-4427	342	1	investment	investment	NOUN
gs-4427	342	2	in	in	ADP
gs-4427	342	3	manufacturing	manufacturing	NOUN
gs-4427	342	4	innovation	innovation	NOUN
gs-4427	342	5	is	be	AUX
gs-4427	342	6	essential	essential	ADJ
gs-4427	342	7	to	to	PART
gs-4427	342	8	ensure	ensure	VERB
gs-4427	342	9	scalability	scalability	NOUN
gs-4427	342	10	,	,	PUNCT
gs-4427	342	11	reproducibility	reproducibility	NOUN
gs-4427	342	12	,	,	PUNCT
gs-4427	342	13	and	and	CCONJ
gs-4427	342	14	global	global	ADJ
gs-4427	342	15	accessibility	accessibility	NOUN
gs-4427	342	16	of	of	ADP
gs-4427	342	17	gene	gene	NOUN
gs-4427	342	18	therapies	therapy	NOUN
gs-4427	342	19	.	.	PUNCT
gs-4427	343	1	the	the	DET
gs-4427	343	2	adoption	adoption	NOUN
gs-4427	343	3	of	of	ADP
gs-4427	343	4	closed	closed	ADJ
gs-4427	343	5	,	,	PUNCT
gs-4427	343	6	automated	automate	VERB
gs-4427	343	7	manufacturing	manufacturing	NOUN
gs-4427	343	8	systems	system	NOUN
gs-4427	343	9	,	,	PUNCT
gs-4427	343	10	point	point	NOUN
gs-4427	343	11	-	-	PUNCT
gs-4427	343	12	of	of	ADP
gs-4427	343	13	-	-	PUNCT
gs-4427	343	14	care	care	NOUN
gs-4427	343	15	production	production	NOUN
gs-4427	343	16	models	model	NOUN
gs-4427	343	17	,	,	PUNCT
gs-4427	343	18	and	and	CCONJ
gs-4427	343	19	standardized	standardized	ADJ
gs-4427	343	20	quality	quality	NOUN
gs-4427	343	21	control	control	NOUN
gs-4427	343	22	assays	assay	NOUN
gs-4427	343	23	should	should	AUX
gs-4427	343	24	be	be	AUX
gs-4427	343	25	accelerated	accelerate	VERB
gs-4427	343	26	to	to	PART
gs-4427	343	27	reduce	reduce	VERB
gs-4427	343	28	production	production	NOUN
gs-4427	343	29	timelines	timeline	NOUN
gs-4427	343	30	,	,	PUNCT
gs-4427	343	31	lower	low	ADJ
gs-4427	343	32	costs	cost	NOUN
gs-4427	343	33	,	,	PUNCT
gs-4427	343	34	and	and	CCONJ
gs-4427	343	35	minimize	minimize	VERB
gs-4427	343	36	manufacturing	manufacturing	NOUN
gs-4427	343	37	failures	failure	NOUN
gs-4427	343	38	.	.	PUNCT
gs-4427	344	1	parallel	parallel	ADJ
gs-4427	344	2	efforts	effort	NOUN
gs-4427	344	3	should	should	AUX
gs-4427	344	4	focus	focus	VERB
gs-4427	344	5	on	on	ADP
gs-4427	344	6	improving	improve	VERB
gs-4427	344	7	viral	viral	ADJ
gs-4427	344	8	vector	vector	NOUN
gs-4427	344	9	yield	yield	NOUN
gs-4427	344	10	and	and	CCONJ
gs-4427	344	11	purification	purification	NOUN
gs-4427	344	12	efficiency	efficiency	NOUN
gs-4427	344	13	to	to	PART
gs-4427	344	14	support	support	VERB
gs-4427	344	15	broader	broad	ADJ
gs-4427	344	16	application	application	NOUN
gs-4427	344	17	of	of	ADP
gs-4427	344	18	in	in	ADP
gs-4427	344	19	vivo	vivo	ADJ
gs-4427	344	20	gene	gene	NOUN
gs-4427	344	21	therapies	therapy	NOUN
gs-4427	344	22	for	for	ADP
gs-4427	344	23	common	common	ADJ
gs-4427	344	24	diseases	disease	NOUN
gs-4427	344	25	.	.	PUNCT
gs-4427	345	1	from	from	ADP
gs-4427	345	2	a	a	DET
gs-4427	345	3	clinical	clinical	ADJ
gs-4427	345	4	perspective	perspective	NOUN
gs-4427	345	5	,	,	PUNCT
gs-4427	345	6	the	the	DET
gs-4427	345	7	establishment	establishment	NOUN
gs-4427	345	8	of	of	ADP
gs-4427	345	9	standardized	standardized	ADJ
gs-4427	345	10	patient	patient	ADJ
gs-4427	345	11	selection	selection	NOUN
gs-4427	345	12	criteria	criterion	NOUN
gs-4427	345	13	,	,	PUNCT
gs-4427	345	14	biomarkers	biomarker	NOUN
gs-4427	345	15	predictive	predictive	ADJ
gs-4427	345	16	of	of	ADP
gs-4427	345	17	therapeutic	therapeutic	ADJ
gs-4427	345	18	response	response	NOUN
gs-4427	345	19	,	,	PUNCT
gs-4427	345	20	and	and	CCONJ
gs-4427	345	21	harmonized	harmonized	ADJ
gs-4427	345	22	long	long	ADJ
gs-4427	345	23	-	-	PUNCT
gs-4427	345	24	term	term	NOUN
gs-4427	345	25	follow	follow	NOUN
gs-4427	345	26	-	-	PUNCT
gs-4427	345	27	up	up	ADP
gs-4427	345	28	protocols	protocol	NOUN
gs-4427	345	29	is	be	AUX
gs-4427	345	30	strongly	strongly	ADV
gs-4427	345	31	recommended	recommend	VERB
gs-4427	345	32	.	.	PUNCT
gs-4427	346	1	these	these	DET
gs-4427	346	2	measures	measure	NOUN
gs-4427	346	3	will	will	AUX
gs-4427	346	4	enhance	enhance	VERB
gs-4427	346	5	real	real	ADJ
gs-4427	346	6	-	-	PUNCT
gs-4427	346	7	world	world	NOUN
gs-4427	346	8	effectiveness	effectiveness	NOUN
gs-4427	346	9	,	,	PUNCT
gs-4427	346	10	improve	improve	VERB
gs-4427	346	11	safety	safety	NOUN
gs-4427	346	12	monitoring	monitoring	NOUN
gs-4427	346	13	,	,	PUNCT
gs-4427	346	14	and	and	CCONJ
gs-4427	346	15	facilitate	facilitate	VERB
gs-4427	346	16	comparative	comparative	ADJ
gs-4427	346	17	evaluation	evaluation	NOUN
gs-4427	346	18	across	across	ADP
gs-4427	346	19	gene	gene	NOUN
gs-4427	346	20	therapy	therapy	NOUN
gs-4427	346	21	platforms	platform	NOUN
gs-4427	346	22	.	.	PUNCT
gs-4427	347	1	multidisciplinary	multidisciplinary	ADJ
gs-4427	347	2	training	training	NOUN
gs-4427	347	3	programs	program	NOUN
gs-4427	347	4	for	for	ADP
gs-4427	347	5	clinicians	clinician	NOUN
gs-4427	347	6	,	,	PUNCT
gs-4427	347	7	pharmacists	pharmacist	NOUN
gs-4427	347	8	,	,	PUNCT
gs-4427	347	9	and	and	CCONJ
gs-4427	347	10	allied	ally	VERB
gs-4427	347	11	healthcare	healthcare	NOUN
gs-4427	347	12	professionals	professional	NOUN
gs-4427	347	13	should	should	AUX
gs-4427	347	14	be	be	AUX
gs-4427	347	15	expanded	expand	VERB
gs-4427	347	16	to	to	PART
gs-4427	347	17	ensure	ensure	VERB
gs-4427	347	18	safe	safe	ADJ
gs-4427	347	19	administration	administration	NOUN
gs-4427	347	20	,	,	PUNCT
gs-4427	347	21	monitoring	monitoring	NOUN
gs-4427	347	22	,	,	PUNCT
gs-4427	347	23	and	and	CCONJ
gs-4427	347	24	long	long	ADJ
gs-4427	347	25	-	-	PUNCT
gs-4427	347	26	term	term	NOUN
gs-4427	347	27	management	management	NOUN
gs-4427	347	28	of	of	ADP
gs-4427	347	29	patients	patient	NOUN
gs-4427	347	30	receiving	receive	VERB
gs-4427	347	31	gene	gene	NOUN
gs-4427	347	32	-	-	PUNCT
gs-4427	347	33	based	base	VERB
gs-4427	347	34	treatments	treatment	NOUN
gs-4427	347	35	.	.	PUNCT
gs-4427	348	1	regulatory	regulatory	ADJ
gs-4427	348	2	agencies	agency	NOUN
gs-4427	348	3	and	and	CCONJ
gs-4427	348	4	policymakers	policymaker	NOUN
gs-4427	348	5	should	should	AUX
gs-4427	348	6	continue	continue	VERB
gs-4427	348	7	to	to	PART
gs-4427	348	8	refine	refine	VERB
gs-4427	348	9	adaptive	adaptive	ADJ
gs-4427	348	10	approval	approval	NOUN
gs-4427	348	11	frameworks	framework	NOUN
gs-4427	348	12	that	that	PRON
gs-4427	348	13	balance	balance	VERB
gs-4427	348	14	early	early	ADV
gs-4427	348	15	patient	patient	ADJ
gs-4427	348	16	access	access	NOUN
gs-4427	348	17	with	with	ADP
gs-4427	348	18	rigorous	rigorous	ADJ
gs-4427	348	19	safety	safety	NOUN
gs-4427	348	20	oversight	oversight	NOUN
gs-4427	348	21	.	.	PUNCT
gs-4427	349	1	platform	platform	NOUN
gs-4427	349	2	-	-	PUNCT
gs-4427	349	3	based	base	VERB
gs-4427	349	4	regulatory	regulatory	ADJ
gs-4427	349	5	approaches	approach	NOUN
gs-4427	349	6	and	and	CCONJ
gs-4427	349	7	flexible	flexible	ADJ
gs-4427	349	8	pathways	pathway	NOUN
gs-4427	349	9	for	for	ADP
gs-4427	349	10	ultra	ultra	ADJ
gs-4427	349	11	-	-	ADJ
gs-4427	349	12	rare	rare	ADJ
gs-4427	349	13	and	and	CCONJ
gs-4427	349	14	personalized	personalized	ADJ
gs-4427	349	15	therapies	therapy	NOUN
gs-4427	349	16	should	should	AUX
gs-4427	349	17	be	be	AUX
gs-4427	349	18	further	far	ADV
gs-4427	349	19	developed	develop	VERB
gs-4427	349	20	,	,	PUNCT
gs-4427	349	21	supported	support	VERB
gs-4427	349	22	by	by	ADP
gs-4427	349	23	international	international	ADJ
gs-4427	349	24	collaboration	collaboration	NOUN
gs-4427	349	25	and	and	CCONJ
gs-4427	349	26	data	datum	NOUN
gs-4427	349	27	sharing	sharing	NOUN
gs-4427	349	28	.	.	PUNCT
gs-4427	350	1	in	in	ADP
gs-4427	350	2	parallel	parallel	ADJ
gs-4427	350	3	,	,	PUNCT
gs-4427	350	4	ethical	ethical	ADJ
gs-4427	350	5	governance	governance	NOUN
gs-4427	350	6	structures	structure	NOUN
gs-4427	350	7	must	must	AUX
gs-4427	350	8	be	be	AUX
gs-4427	350	9	strengthened	strengthen	VERB
gs-4427	350	10	to	to	PART
gs-4427	350	11	address	address	VERB
gs-4427	350	12	concerns	concern	NOUN
gs-4427	350	13	related	relate	VERB
gs-4427	350	14	to	to	ADP
gs-4427	350	15	georgian	georgian	NOUN
gs-4427	350	16	scientists/	scientists/	NUM
gs-4427	350	17	.	.	PUNCT
gs-4427	351	1	7	7	NUM
gs-4427	351	2	n	n	DET
gs-4427	351	3	4	4	NUM
gs-4427	351	4	,	,	PUNCT
gs-4427	351	5	2025	2025	NUM
gs-4427	351	6	653	653	NUM
gs-4427	351	7	informed	inform	VERB
gs-4427	351	8	consent	consent	NOUN
gs-4427	351	9	,	,	PUNCT
gs-4427	351	10	long	long	ADJ
gs-4427	351	11	-	-	PUNCT
gs-4427	351	12	term	term	NOUN
gs-4427	351	13	risk	risk	NOUN
gs-4427	351	14	,	,	PUNCT
gs-4427	351	15	equitable	equitable	ADJ
gs-4427	351	16	access	access	NOUN
gs-4427	351	17	,	,	PUNCT
gs-4427	351	18	and	and	CCONJ
gs-4427	351	19	responsible	responsible	ADJ
gs-4427	351	20	use	use	NOUN
gs-4427	351	21	of	of	ADP
gs-4427	351	22	genome	genome	NOUN
gs-4427	351	23	editing	editing	NOUN
gs-4427	351	24	technologies	technology	NOUN
gs-4427	351	25	.	.	PUNCT
gs-4427	352	1	references	reference	NOUN
gs-4427	352	2	1	1	NUM
gs-4427	352	3	.	.	PUNCT
gs-4427	353	1	wang	wang	PROPN
gs-4427	353	2	y	y	PROPN
gs-4427	353	3	,	,	PUNCT
gs-4427	353	4	bruggeman	bruggeman	PROPN
gs-4427	353	5	kf	kf	PROPN
gs-4427	353	6	,	,	PUNCT
gs-4427	353	7	franks	frank	NOUN
gs-4427	353	8	s	s	PROPN
gs-4427	353	9	,	,	PUNCT
gs-4427	353	10	et	et	PROPN
gs-4427	353	11	al	al	PROPN
gs-4427	353	12	.	.	PROPN
gs-4427	353	13	is	be	AUX
gs-4427	353	14	viral	viral	ADJ
gs-4427	353	15	vector	vector	NOUN
gs-4427	353	16	gene	gene	NOUN
gs-4427	353	17	delivery	delivery	NOUN
gs-4427	353	18	more	more	ADV
gs-4427	353	19	effective	effective	ADJ
gs-4427	353	20	using	use	VERB
gs-4427	353	21	biomaterials	biomaterial	NOUN
gs-4427	353	22	?	?	PUNCT
gs-4427	354	1	adv	adv	PROPN
gs-4427	354	2	healthcare	healthcare	PROPN
gs-4427	354	3	mater	mater	NOUN
gs-4427	354	4	.	.	PUNCT
gs-4427	355	1	2021;10(1):2001238	2021;10(1):2001238	NUM
gs-4427	355	2	.	.	NOUN
gs-4427	355	3	2	2	NUM
gs-4427	355	4	.	.	X
gs-4427	355	5	schäfer	schäfer	NOUN
gs-4427	355	6	-	-	PUNCT
gs-4427	355	7	korting	korte	VERB
gs-4427	355	8	m.	m.	NOUN
gs-4427	355	9	looking	look	VERB
gs-4427	355	10	to	to	ADP
gs-4427	355	11	the	the	DET
gs-4427	355	12	future	future	NOUN
gs-4427	355	13	:	:	PUNCT
gs-4427	355	14	drug	drug	NOUN
gs-4427	355	15	delivery	delivery	NOUN
gs-4427	355	16	and	and	CCONJ
gs-4427	355	17	targeting	target	VERB
gs-4427	355	18	in	in	ADP
gs-4427	355	19	the	the	DET
gs-4427	355	20	prophylaxis	prophylaxis	NOUN
gs-4427	355	21	and	and	CCONJ
gs-4427	355	22	therapy	therapy	NOUN
gs-4427	355	23	of	of	ADP
gs-4427	355	24	severe	severe	ADJ
gs-4427	355	25	and	and	CCONJ
gs-4427	355	26	chronic	chronic	ADJ
gs-4427	355	27	diseases	disease	NOUN
gs-4427	355	28	.	.	PUNCT
gs-4427	356	1	handb	handb	NOUN
gs-4427	356	2	exp	exp	NOUN
gs-4427	356	3	pharmacol	pharmacol	PROPN
gs-4427	356	4	.	.	PUNCT
gs-4427	356	5	2024;284:389–411	2024;284:389–411	NUM
gs-4427	356	6	.	.	PUNCT
gs-4427	357	1	3	3	X
gs-4427	357	2	.	.	X
gs-4427	357	3	zhao	zhao	PROPN
gs-4427	357	4	z	z	PROPN
gs-4427	357	5	,	,	PUNCT
gs-4427	357	6	anselmo	anselmo	VERB
gs-4427	357	7	ac	ac	PROPN
gs-4427	357	8	,	,	PUNCT
gs-4427	357	9	mitragotri	mitragotri	ADJ
gs-4427	357	10	s.	s.	PROPN
gs-4427	357	11	viral	viral	ADJ
gs-4427	357	12	vector	vector	NOUN
gs-4427	357	13	-	-	PUNCT
gs-4427	357	14	based	base	VERB
gs-4427	357	15	gene	gene	NOUN
gs-4427	357	16	therapies	therapy	NOUN
gs-4427	357	17	in	in	ADP
gs-4427	357	18	the	the	DET
gs-4427	357	19	clinic	clinic	NOUN
gs-4427	357	20	.	.	PUNCT
gs-4427	358	1	bioeng	bioeng	PROPN
gs-4427	358	2	transl	transl	PROPN
gs-4427	358	3	med	med	PROPN
gs-4427	358	4	.	.	PUNCT
gs-4427	359	1	2022;7(1):e10258	2022;7(1):e10258	NUM
gs-4427	359	2	.	.	PUNCT
gs-4427	360	1	4	4	NUM
gs-4427	360	2	.	.	X
gs-4427	360	3	sulashvili	sulashvili	NOUN
gs-4427	360	4	,	,	PUNCT
gs-4427	360	5	n.	n.	NOUN
gs-4427	360	6	,	,	PUNCT
gs-4427	360	7	imerlishvili	imerlishvili	NOUN
gs-4427	360	8	,	,	PUNCT
gs-4427	360	9	i.	i.	PROPN
gs-4427	360	10	,	,	PUNCT
gs-4427	360	11	kocharyan	kocharyan	PROPN
gs-4427	360	12	,	,	PUNCT
gs-4427	360	13	s.	s.	PROPN
gs-4427	360	14	,	,	PUNCT
gs-4427	360	15	gabunia	gabunia	PROPN
gs-4427	360	16	,	,	PUNCT
gs-4427	360	17	l.	l.	PROPN
gs-4427	360	18	,	,	PUNCT
gs-4427	360	19	gorgaslidze	gorgaslidze	PROPN
gs-4427	360	20	,	,	PUNCT
gs-4427	360	21	n.	n.	NOUN
gs-4427	360	22	,	,	PUNCT
gs-4427	360	23	buleishvili	buleishvili	NOUN
gs-4427	360	24	,	,	PUNCT
gs-4427	360	25	m.	m.	NOUN
gs-4427	360	26	,	,	PUNCT
gs-4427	360	27	aphkhazava	aphkhazava	PROPN
gs-4427	360	28	,	,	PUNCT
gs-4427	360	29	d.	d.	PROPN
gs-4427	360	30	(	(	PUNCT
gs-4427	360	31	2025	2025	NUM
gs-4427	360	32	)	)	PUNCT
gs-4427	360	33	.	.	PUNCT
gs-4427	361	1	bioinformatics	bioinformatics	NOUN
gs-4427	361	2	approaches	approach	VERB
gs-4427	361	3	for	for	ADP
gs-4427	361	4	multi	multi	ADJ
gs-4427	361	5	-	-	ADJ
gs-4427	361	6	omics	omics	ADJ
gs-4427	361	7	analysis	analysis	NOUN
gs-4427	361	8	of	of	ADP
gs-4427	361	9	the	the	DET
gs-4427	361	10	tumor	tumor	NOUN
gs-4427	361	11	microenvironment	microenvironment	NOUN
gs-4427	361	12	:	:	PUNCT
gs-4427	361	13	integrating	integrate	VERB
gs-4427	361	14	proteomics	proteomic	NOUN
gs-4427	361	15	,	,	PUNCT
gs-4427	361	16	exosomes	exosome	NOUN
gs-4427	361	17	and	and	CCONJ
gs-4427	361	18	immune	immune	ADJ
gs-4427	361	19	signaling	signal	VERB
gs-4427	361	20	.	.	PUNCT
gs-4427	362	1	georgian	georgian	ADJ
gs-4427	362	2	scientists	scientist	NOUN
gs-4427	362	3	,	,	PUNCT
gs-4427	362	4	7(4	7(4	NUM
gs-4427	362	5	)	)	PUNCT
gs-4427	362	6	,	,	PUNCT
gs-4427	362	7	333–385	333–385	NUM
gs-4427	362	8	.	.	PUNCT
gs-4427	363	1	https://doi.org/10.52340/gs.2025.07.04.18	https://doi.org/10.52340/gs.2025.07.04.18	PROPN
gs-4427	363	2	5	5	NUM
gs-4427	363	3	.	.	PUNCT
gs-4427	363	4	jiang	jiang	PROPN
gs-4427	364	1	l	l	PROPN
gs-4427	364	2	,	,	PUNCT
gs-4427	364	3	wang	wang	PROPN
gs-4427	364	4	d	d	PROPN
gs-4427	364	5	,	,	PUNCT
gs-4427	364	6	he	he	PRON
gs-4427	364	7	y	y	PROPN
gs-4427	364	8	,	,	PUNCT
gs-4427	364	9	shu	shu	PROPN
gs-4427	364	10	y.	y.	PROPN
gs-4427	364	11	advances	advance	VERB
gs-4427	364	12	in	in	ADP
gs-4427	364	13	gene	gene	NOUN
gs-4427	364	14	therapy	therapy	NOUN
gs-4427	364	15	hold	hold	VERB
gs-4427	364	16	promise	promise	NOUN
gs-4427	364	17	for	for	ADP
gs-4427	364	18	treating	treat	VERB
gs-4427	364	19	hereditary	hereditary	ADJ
gs-4427	364	20	hearing	hearing	NOUN
gs-4427	364	21	loss	loss	NOUN
gs-4427	364	22	.	.	PUNCT
gs-4427	365	1	mol	mol	ADP
gs-4427	365	2	ther	ther	ADV
gs-4427	365	3	.	.	PUNCT
gs-4427	366	1	2023;31(4):934–50	2023;31(4):934–50	NUM
gs-4427	366	2	.	.	PUNCT
gs-4427	367	1	6	6	NUM
gs-4427	367	2	.	.	X
gs-4427	367	3	ferrari	ferrari	PROPN
gs-4427	367	4	g	g	PROPN
gs-4427	367	5	,	,	PUNCT
gs-4427	367	6	thrasher	thrasher	NOUN
gs-4427	367	7	aj	aj	PROPN
gs-4427	367	8	,	,	PUNCT
gs-4427	367	9	aiuti	aiuti	PROPN
gs-4427	367	10	a.	a.	NOUN
gs-4427	367	11	gene	gene	NOUN
gs-4427	367	12	therapy	therapy	NOUN
gs-4427	367	13	using	use	VERB
gs-4427	367	14	haematopoietic	haematopoietic	ADJ
gs-4427	367	15	stem	stem	NOUN
gs-4427	367	16	and	and	CCONJ
gs-4427	367	17	progenitor	progenitor	NOUN
gs-4427	367	18	cells	cell	NOUN
gs-4427	367	19	.	.	PUNCT
gs-4427	368	1	nat	nat	PROPN
gs-4427	368	2	rev	rev	PROPN
gs-4427	368	3	genet	genet	PROPN
gs-4427	368	4	.	.	PUNCT
gs-4427	369	1	2021;22(4):216–34	2021;22(4):216–34	NUM
gs-4427	369	2	.	.	NOUN
gs-4427	369	3	7	7	NUM
gs-4427	369	4	.	.	PUNCT
gs-4427	369	5	pan	pan	PROPN
gs-4427	369	6	x	x	PROPN
gs-4427	369	7	,	,	PUNCT
gs-4427	369	8	veroniaina	veroniaina	PROPN
gs-4427	369	9	h	h	PROPN
gs-4427	369	10	,	,	PUNCT
gs-4427	369	11	su	su	PROPN
gs-4427	369	12	n	n	PROPN
gs-4427	369	13	,	,	PUNCT
gs-4427	369	14	et	et	PROPN
gs-4427	369	15	al	al	PROPN
gs-4427	369	16	.	.	PROPN
gs-4427	369	17	applications	application	NOUN
gs-4427	369	18	and	and	CCONJ
gs-4427	369	19	developments	development	NOUN
gs-4427	369	20	of	of	ADP
gs-4427	369	21	gene	gene	NOUN
gs-4427	369	22	therapy	therapy	NOUN
gs-4427	369	23	drug	drug	NOUN
gs-4427	369	24	delivery	delivery	NOUN
gs-4427	369	25	systems	system	NOUN
gs-4427	369	26	for	for	ADP
gs-4427	369	27	genetic	genetic	ADJ
gs-4427	369	28	diseases	disease	NOUN
gs-4427	369	29	.	.	PUNCT
gs-4427	370	1	asian	asian	PROPN
gs-4427	370	2	j	j	PROPN
gs-4427	370	3	pharm	pharm	PROPN
gs-4427	370	4	sci	sci	PROPN
gs-4427	370	5	.	.	PUNCT
gs-4427	370	6	2021;16(6):687–703	2021;16(6):687–703	NUM
gs-4427	370	7	.	.	NOUN
gs-4427	370	8	8	8	NUM
gs-4427	370	9	.	.	PUNCT
gs-4427	370	10	li	li	PROPN
gs-4427	370	11	c	c	PROPN
gs-4427	370	12	,	,	PUNCT
gs-4427	370	13	samulski	samulski	PROPN
gs-4427	370	14	rj	rj	PROPN
gs-4427	370	15	.	.	PUNCT
gs-4427	371	1	engineering	engineering	NOUN
gs-4427	371	2	adeno	adeno	NOUN
gs-4427	371	3	-	-	PUNCT
gs-4427	371	4	associated	associate	VERB
gs-4427	371	5	virus	virus	NOUN
gs-4427	371	6	vectors	vector	NOUN
gs-4427	371	7	for	for	ADP
gs-4427	371	8	gene	gene	NOUN
gs-4427	371	9	therapy	therapy	NOUN
gs-4427	371	10	.	.	PUNCT
gs-4427	372	1	nat	nat	PROPN
gs-4427	372	2	rev	rev	PROPN
gs-4427	372	3	genet	genet	PROPN
gs-4427	372	4	.	.	PUNCT
gs-4427	373	1	2020;21(4):255–72	2020;21(4):255–72	NUM
gs-4427	373	2	.	.	NOUN
gs-4427	374	1	9	9	X
gs-4427	374	2	.	.	X
gs-4427	375	1	trivedi	trivedi	PROPN
gs-4427	375	2	pd	pd	PROPN
gs-4427	375	3	,	,	PUNCT
gs-4427	375	4	byrne	byrne	ADJ
gs-4427	375	5	bj	bj	PROPN
gs-4427	375	6	,	,	PUNCT
gs-4427	375	7	corti	corti	PROPN
gs-4427	375	8	m.	m.	NOUN
gs-4427	375	9	evolving	evolve	VERB
gs-4427	375	10	horizons	horizon	NOUN
gs-4427	375	11	:	:	PUNCT
gs-4427	375	12	adenovirus	adenovirus	NOUN
gs-4427	375	13	vectors	vector	NOUN
gs-4427	375	14	’	'	PUNCT
gs-4427	375	15	timeless	timeless	ADJ
gs-4427	375	16	influence	influence	NOUN
gs-4427	375	17	on	on	ADP
gs-4427	375	18	cancer	cancer	NOUN
gs-4427	375	19	,	,	PUNCT
gs-4427	375	20	gene	gene	NOUN
gs-4427	375	21	therapy	therapy	NOUN
gs-4427	375	22	and	and	CCONJ
gs-4427	375	23	vaccines	vaccine	NOUN
gs-4427	375	24	.	.	PUNCT
gs-4427	376	1	viruses	virus	NOUN
gs-4427	376	2	.	.	PUNCT
gs-4427	377	1	2023;15(12):2378	2023;15(12):2378	X
gs-4427	377	2	.	.	NOUN
gs-4427	377	3	10	10	NUM
gs-4427	377	4	.	.	PUNCT
gs-4427	377	5	matsunaga	matsunaga	PROPN
gs-4427	377	6	w	w	PROPN
gs-4427	377	7	,	,	PUNCT
gs-4427	377	8	gotoh	gotoh	ADJ
gs-4427	377	9	a.	a.	NOUN
gs-4427	377	10	adenovirus	adenovirus	NOUN
gs-4427	377	11	as	as	ADP
gs-4427	377	12	a	a	DET
gs-4427	377	13	vector	vector	NOUN
gs-4427	377	14	and	and	CCONJ
gs-4427	377	15	oncolytic	oncolytic	ADJ
gs-4427	377	16	virus	virus	NOUN
gs-4427	377	17	.	.	PUNCT
gs-4427	378	1	curr	curr	PROPN
gs-4427	378	2	issues	issue	NOUN
gs-4427	378	3	mol	mol	ADP
gs-4427	378	4	biol	biol	PROPN
gs-4427	378	5	.	.	PUNCT
gs-4427	379	1	2023;45(6):4826–40	2023;45(6):4826–40	X
gs-4427	379	2	.	.	PUNCT
gs-4427	380	1	11	11	NUM
gs-4427	380	2	.	.	X
gs-4427	380	3	shirley	shirley	PROPN
gs-4427	380	4	jl	jl	PROPN
gs-4427	380	5	,	,	PUNCT
gs-4427	380	6	de	de	PROPN
gs-4427	380	7	jong	jong	PROPN
gs-4427	380	8	yp	yp	PROPN
gs-4427	380	9	,	,	PUNCT
gs-4427	380	10	terhorst	terhorst	NOUN
gs-4427	380	11	c	c	AUX
gs-4427	380	12	,	,	PUNCT
gs-4427	380	13	herzog	herzog	PROPN
gs-4427	380	14	rw	rw	PROPN
gs-4427	380	15	.	.	PROPN
gs-4427	380	16	immune	immune	PROPN
gs-4427	380	17	responses	response	NOUN
gs-4427	380	18	to	to	ADP
gs-4427	380	19	viral	viral	ADJ
gs-4427	380	20	gene	gene	NOUN
gs-4427	380	21	therapy	therapy	NOUN
gs-4427	380	22	vectors	vector	NOUN
gs-4427	380	23	.	.	PUNCT
gs-4427	381	1	mol	mol	ADP
gs-4427	381	2	ther	ther	ADV
gs-4427	381	3	.	.	PUNCT
gs-4427	382	1	2020;28(3):709–22	2020;28(3):709–22	NUM
gs-4427	382	2	.	.	NOUN
gs-4427	382	3	12	12	NUM
gs-4427	382	4	.	.	PUNCT
gs-4427	383	1	sulashvili	sulashvili	NOUN
gs-4427	383	2	,	,	PUNCT
gs-4427	383	3	n.	n.	PROPN
gs-4427	383	4	,	,	PUNCT
gs-4427	383	5	jadhav	jadhav	PROPN
gs-4427	383	6	,	,	PUNCT
gs-4427	383	7	r.	r.	PROPN
gs-4427	383	8	d.	d.	PROPN
gs-4427	383	9	,	,	PUNCT
gs-4427	383	10	beglaryan	beglaryan	ADJ
gs-4427	383	11	,	,	PUNCT
gs-4427	383	12	m.	m.	NOUN
gs-4427	383	13	,	,	PUNCT
gs-4427	383	14	gabunia	gabunia	NOUN
gs-4427	383	15	,	,	PUNCT
gs-4427	383	16	l.	l.	PROPN
gs-4427	383	17	,	,	PUNCT
gs-4427	383	18	gorgaslidze	gorgaslidze	PROPN
gs-4427	383	19	,	,	PUNCT
gs-4427	383	20	n.	n.	NOUN
gs-4427	383	21	,	,	PUNCT
gs-4427	383	22	alavidze	alavidze	PROPN
gs-4427	383	23	,	,	PUNCT
gs-4427	383	24	n.	n.	PROPN
gs-4427	383	25	,	,	PUNCT
gs-4427	383	26	robakidze	robakidze	VERB
gs-4427	383	27	,	,	PUNCT
gs-4427	383	28	k.	k.	PROPN
gs-4427	383	29	(	(	PUNCT
gs-4427	383	30	2025	2025	NUM
gs-4427	383	31	)	)	PUNCT
gs-4427	383	32	.	.	PUNCT
gs-4427	384	1	the	the	DET
gs-4427	384	2	scientific	scientific	ADJ
gs-4427	384	3	discussion	discussion	NOUN
gs-4427	384	4	of	of	ADP
gs-4427	384	5	key	key	ADJ
gs-4427	384	6	issue	issue	NOUN
gs-4427	384	7	aspects	aspect	NOUN
gs-4427	384	8	of	of	ADP
gs-4427	384	9	immunopathogenesis	immunopathogenesis	NOUN
gs-4427	384	10	and	and	CCONJ
gs-4427	384	11	pharmacological	pharmacological	NOUN
gs-4427	384	12	properties	property	NOUN
gs-4427	384	13	and	and	CCONJ
gs-4427	384	14	profiles	profile	NOUN
gs-4427	384	15	in	in	ADP
gs-4427	384	16	relation	relation	NOUN
gs-4427	384	17	to	to	ADP
gs-4427	384	18	adverse	adverse	ADJ
gs-4427	384	19	drug	drug	NOUN
gs-4427	384	20	reactions	reaction	NOUN
gs-4427	384	21	challenges	challenge	NOUN
gs-4427	384	22	,	,	PUNCT
gs-4427	384	23	focus	focus	VERB
gs-4427	384	24	on	on	ADP
gs-4427	384	25	multidimensional	multidimensional	ADJ
gs-4427	384	26	drug	drug	NOUN
gs-4427	384	27	-	-	PUNCT
gs-4427	384	28	induced	induce	VERB
gs-4427	384	29	eosinophilia	eosinophilia	NOUN
gs-4427	384	30	and	and	CCONJ
gs-4427	384	31	systemic	systemic	ADJ
gs-4427	384	32	syndrome	syndrome	NOUN
gs-4427	384	33	.	.	PUNCT
gs-4427	385	1	georgian	georgian	ADJ
gs-4427	385	2	scientists	scientist	NOUN
gs-4427	385	3	,	,	PUNCT
gs-4427	385	4	7(3	7(3	NUM
gs-4427	385	5	)	)	PUNCT
gs-4427	385	6	,	,	PUNCT
gs-4427	385	7	141–179	141–179	NUM
gs-4427	385	8	.	.	PUNCT
gs-4427	385	9	https://doi.org/10.52340/gs.2025.07.03.13	https://doi.org/10.52340/gs.2025.07.03.13	X
gs-4427	385	10	.	.	PROPN
gs-4427	386	1	13	13	NUM
gs-4427	386	2	.	.	PUNCT
gs-4427	387	1	wang	wang	PROPN
gs-4427	387	2	j	j	PROPN
gs-4427	387	3	-	-	PROPN
gs-4427	387	4	h	h	PROPN
gs-4427	387	5	,	,	PUNCT
gs-4427	387	6	gessler	gessler	NOUN
gs-4427	387	7	dj	dj	PROPN
gs-4427	387	8	,	,	PUNCT
gs-4427	387	9	zhan	zhan	PROPN
gs-4427	387	10	w	w	PROPN
gs-4427	387	11	,	,	PUNCT
gs-4427	387	12	gallagher	gallagher	PROPN
gs-4427	387	13	tl	tl	PROPN
gs-4427	387	14	,	,	PUNCT
gs-4427	387	15	gao	gao	PROPN
gs-4427	387	16	g.	g.	PROPN
gs-4427	387	17	adeno	adeno	PROPN
gs-4427	387	18	-	-	PUNCT
gs-4427	387	19	associated	associate	VERB
gs-4427	387	20	virus	virus	NOUN
gs-4427	387	21	as	as	ADP
gs-4427	387	22	a	a	DET
gs-4427	387	23	delivery	delivery	NOUN
gs-4427	387	24	vector	vector	NOUN
gs-4427	387	25	for	for	ADP
gs-4427	387	26	gene	gene	NOUN
gs-4427	387	27	therapy	therapy	NOUN
gs-4427	387	28	of	of	ADP
gs-4427	387	29	human	human	ADJ
gs-4427	387	30	diseases	disease	NOUN
gs-4427	387	31	.	.	PUNCT
gs-4427	388	1	signal	signal	PROPN
gs-4427	388	2	transduct	transduct	NOUN
gs-4427	388	3	target	target	NOUN
gs-4427	388	4	ther	ther	ADV
gs-4427	388	5	.	.	PUNCT
gs-4427	389	1	2024;9(1):78	2024;9(1):78	X
gs-4427	389	2	.	.	PUNCT
gs-4427	390	1	georgian	georgian	PROPN
gs-4427	390	2	scientists/	scientists/	NUM
gs-4427	390	3	.	.	PUNCT
gs-4427	391	1	7	7	NUM
gs-4427	391	2	n	n	DET
gs-4427	391	3	4	4	NUM
gs-4427	391	4	,	,	PUNCT
gs-4427	391	5	2025	2025	NUM
gs-4427	391	6	654	654	NUM
gs-4427	391	7	14	14	NUM
gs-4427	391	8	.	.	PUNCT
gs-4427	392	1	fajardo	fajardo	PROPN
gs-4427	392	2	-	-	PUNCT
gs-4427	392	3	serrano	serrano	PROPN
gs-4427	392	4	a	a	PRON
gs-4427	392	5	,	,	PUNCT
gs-4427	392	6	rico	rico	PROPN
gs-4427	392	7	aj	aj	PROPN
gs-4427	392	8	,	,	PUNCT
gs-4427	392	9	roda	roda	PROPN
gs-4427	392	10	e	e	PROPN
gs-4427	392	11	,	,	PUNCT
gs-4427	392	12	honrubia	honrubia	VERB
gs-4427	392	13	a	a	NOUN
gs-4427	392	14	,	,	PUNCT
gs-4427	392	15	arrieta	arrieta	PROPN
gs-4427	392	16	s	s	PROPN
gs-4427	392	17	,	,	PUNCT
gs-4427	392	18	ariznabarreta	ariznabarreta	PROPN
gs-4427	392	19	g	g	PROPN
gs-4427	392	20	,	,	PUNCT
gs-4427	392	21	chocarro	chocarro	PROPN
gs-4427	392	22	j	j	PROPN
gs-4427	392	23	,	,	PUNCT
gs-4427	392	24	lorenzo	lorenzo	PROPN
gs-4427	392	25	-	-	PUNCT
gs-4427	392	26	ramos	ramos	PROPN
gs-4427	392	27	e	e	PROPN
gs-4427	392	28	,	,	PUNCT
gs-4427	392	29	pejenaute	pejenaute	VERB
gs-4427	392	30	a	a	DET
gs-4427	392	31	,	,	PUNCT
gs-4427	392	32	vázquez	vázquez	NOUN
gs-4427	392	33	a	a	X
gs-4427	392	34	,	,	PUNCT
gs-4427	392	35	lanciego	lanciego	PROPN
gs-4427	392	36	jl	jl	PROPN
gs-4427	392	37	.	.	PUNCT
gs-4427	392	38	adeno	adeno	NOUN
gs-4427	392	39	-	-	PUNCT
gs-4427	392	40	associated	associate	VERB
gs-4427	392	41	viral	viral	ADJ
gs-4427	392	42	vectors	vector	NOUN
gs-4427	392	43	as	as	ADP
gs-4427	392	44	versatile	versatile	ADJ
gs-4427	392	45	tools	tool	NOUN
gs-4427	392	46	for	for	ADP
gs-4427	392	47	parkinson	parkinson	NOUN
gs-4427	392	48	’s	’s	PART
gs-4427	392	49	research	research	NOUN
gs-4427	392	50	,	,	PUNCT
gs-4427	392	51	both	both	PRON
gs-4427	392	52	for	for	ADP
gs-4427	392	53	disease	disease	NOUN
gs-4427	392	54	modeling	model	VERB
gs-4427	392	55	purposes	purpose	NOUN
gs-4427	392	56	and	and	CCONJ
gs-4427	392	57	for	for	ADP
gs-4427	392	58	therapeutic	therapeutic	ADJ
gs-4427	392	59	uses	use	NOUN
gs-4427	392	60	.	.	PUNCT
gs-4427	393	1	int	int	PROPN
gs-4427	393	2	j	j	PROPN
gs-4427	393	3	mol	mol	ADP
gs-4427	393	4	sci	sci	PROPN
gs-4427	393	5	.	.	PUNCT
gs-4427	394	1	2021;22(12):6389	2021;22(12):6389	NUM
gs-4427	394	2	.	.	NOUN
gs-4427	394	3	15	15	NUM
gs-4427	394	4	.	.	X
gs-4427	394	5	asmamaw	asmamaw	PROPN
gs-4427	394	6	mengstie	mengstie	PROPN
gs-4427	394	7	m.	m.	PROPN
gs-4427	394	8	viral	viral	ADJ
gs-4427	394	9	vectors	vector	NOUN
gs-4427	394	10	for	for	ADP
gs-4427	394	11	the	the	DET
gs-4427	394	12	in	in	ADP
gs-4427	394	13	vivo	vivo	ADJ
gs-4427	394	14	delivery	delivery	NOUN
gs-4427	394	15	of	of	ADP
gs-4427	394	16	crispr	crispr	ADJ
gs-4427	394	17	components	component	NOUN
gs-4427	394	18	:	:	PUNCT
gs-4427	394	19	advances	advance	NOUN
gs-4427	394	20	and	and	CCONJ
gs-4427	394	21	challenges	challenge	NOUN
gs-4427	394	22	.	.	PUNCT
gs-4427	395	1	front	front	ADJ
gs-4427	395	2	bioeng	bioeng	PROPN
gs-4427	395	3	biotechnol	biotechnol	NOUN
gs-4427	395	4	.	.	PUNCT
gs-4427	396	1	2022;10:895713	2022;10:895713	NUM
gs-4427	396	2	.	.	PUNCT
gs-4427	397	1	16	16	NUM
gs-4427	397	2	.	.	PUNCT
gs-4427	398	1	zhu	zhu	PROPN
gs-4427	398	2	s	s	PROPN
gs-4427	398	3	,	,	PUNCT
gs-4427	398	4	viejo	viejo	PROPN
gs-4427	398	5	-	-	PUNCT
gs-4427	398	6	borbolla	borbolla	NOUN
gs-4427	398	7	a.	a.	NOUN
gs-4427	398	8	pathogenesis	pathogenesis	NOUN
gs-4427	398	9	and	and	CCONJ
gs-4427	398	10	virulence	virulence	NOUN
gs-4427	398	11	of	of	ADP
gs-4427	398	12	herpes	herpe	NOUN
gs-4427	398	13	simplex	simplex	NOUN
gs-4427	398	14	virus	virus	NOUN
gs-4427	398	15	.	.	PUNCT
gs-4427	399	1	virulence	virulence	NOUN
gs-4427	399	2	.	.	PUNCT
gs-4427	400	1	2021;12(1):2670–702	2021;12(1):2670–702	X
gs-4427	400	2	.	.	X
gs-4427	400	3	17	17	NUM
gs-4427	400	4	.	.	PUNCT
gs-4427	401	1	wilms	wilms	PROPN
gs-4427	401	2	l	l	PROPN
gs-4427	401	3	,	,	PUNCT
gs-4427	401	4	weßollek	weßollek	PROPN
gs-4427	401	5	k	k	NOUN
gs-4427	401	6	,	,	PUNCT
gs-4427	401	7	peeters	peeter	NOUN
gs-4427	401	8	tb	tb	NOUN
gs-4427	401	9	,	,	PUNCT
gs-4427	401	10	yazdi	yazdi	ADJ
gs-4427	401	11	as	as	ADP
gs-4427	401	12	.	.	PUNCT
gs-4427	401	13	infections	infection	NOUN
gs-4427	401	14	with	with	ADP
gs-4427	401	15	herpes	herpe	NOUN
gs-4427	401	16	simplex	simplex	NOUN
gs-4427	401	17	and	and	CCONJ
gs-4427	401	18	varicella	varicella	NOUN
gs-4427	401	19	zoster	zoster	NOUN
gs-4427	401	20	virus	virus	PROPN
gs-4427	401	21	.	.	PUNCT
gs-4427	402	1	jddg	jddg	PROPN
gs-4427	402	2	:	:	PUNCT
gs-4427	403	1	j	j	PROPN
gs-4427	403	2	dtsch	dtsch	PROPN
gs-4427	403	3	dermatol	dermatol	NOUN
gs-4427	403	4	ges	ges	PROPN
gs-4427	403	5	.	.	PROPN
gs-4427	403	6	2022;20(10):1327–1351	2022;20(10):1327–1351	NOUN
gs-4427	403	7	.	.	PUNCT
gs-4427	404	1	18	18	NUM
gs-4427	404	2	.	.	PUNCT
gs-4427	404	3	farsimadan	farsimadan	PROPN
gs-4427	404	4	m	m	PROPN
gs-4427	404	5	,	,	PUNCT
gs-4427	404	6	motamedifar	motamedifar	ADV
gs-4427	404	7	m.	m.	NOUN
gs-4427	404	8	the	the	DET
gs-4427	404	9	effects	effect	NOUN
gs-4427	404	10	of	of	ADP
gs-4427	404	11	human	human	ADJ
gs-4427	404	12	immunodeficiency	immunodeficiency	NOUN
gs-4427	404	13	virus	virus	NOUN
gs-4427	404	14	,	,	PUNCT
gs-4427	404	15	human	human	ADJ
gs-4427	404	16	papillomavirus	papillomavirus	NOUN
gs-4427	404	17	,	,	PUNCT
gs-4427	404	18	herpes	herpe	NOUN
gs-4427	404	19	simplex	simplex	NOUN
gs-4427	404	20	virus-1	virus-1	PROPN
gs-4427	404	21	and	and	CCONJ
gs-4427	404	22	-2	-2	INTJ
gs-4427	404	23	,	,	PUNCT
gs-4427	404	24	human	human	NOUN
gs-4427	404	25	herpesvirus-6	herpesvirus-6	NOUN
gs-4427	404	26	and	and	CCONJ
gs-4427	404	27	-8	-8	NOUN
gs-4427	404	28	,	,	PUNCT
gs-4427	404	29	cytomegalovirus	cytomegalovirus	NOUN
gs-4427	404	30	,	,	PUNCT
gs-4427	404	31	and	and	CCONJ
gs-4427	404	32	hepatitis	hepatitis	PROPN
gs-4427	404	33	b	b	PROPN
gs-4427	404	34	and	and	CCONJ
gs-4427	404	35	c	c	PROPN
gs-4427	404	36	virus	virus	NOUN
gs-4427	404	37	on	on	ADP
gs-4427	404	38	female	female	ADJ
gs-4427	404	39	fertility	fertility	NOUN
gs-4427	404	40	and	and	CCONJ
gs-4427	404	41	pregnancy	pregnancy	NOUN
gs-4427	404	42	.	.	PUNCT
gs-4427	405	1	br	br	PROPN
gs-4427	406	1	j	j	PROPN
gs-4427	406	2	biomed	biome	VERB
gs-4427	406	3	sci	sci	PROPN
gs-4427	406	4	.	.	PUNCT
gs-4427	407	1	2021;78(1):1–11	2021;78(1):1–11	PROPN
gs-4427	407	2	.	.	PROPN
gs-4427	408	1	19	19	NUM
gs-4427	408	2	.	.	PUNCT
gs-4427	408	3	au	au	PROPN
gs-4427	408	4	hk	hk	PROPN
gs-4427	408	5	,	,	PUNCT
gs-4427	408	6	isalan	isalan	PROPN
gs-4427	408	7	m	m	PROPN
gs-4427	408	8	,	,	PUNCT
gs-4427	408	9	mielcarek	mielcarek	PROPN
gs-4427	408	10	m.	m.	NOUN
gs-4427	408	11	gene	gene	NOUN
gs-4427	408	12	therapy	therapy	NOUN
gs-4427	408	13	advances	advance	VERB
gs-4427	408	14	:	:	PUNCT
gs-4427	408	15	a	a	DET
gs-4427	408	16	meta	meta	ADJ
gs-4427	408	17	-	-	PUNCT
gs-4427	408	18	analysis	analysis	NOUN
gs-4427	408	19	of	of	ADP
gs-4427	408	20	aav	aav	NOUN
gs-4427	408	21	usage	usage	NOUN
gs-4427	408	22	in	in	ADP
gs-4427	408	23	clinical	clinical	ADJ
gs-4427	408	24	settings	setting	NOUN
gs-4427	408	25	.	.	PUNCT
gs-4427	409	1	front	front	PROPN
gs-4427	409	2	med	med	PROPN
gs-4427	409	3	.	.	PUNCT
gs-4427	410	1	2022;8:809118	2022;8:809118	NUM
gs-4427	410	2	.	.	PUNCT
gs-4427	411	1	20	20	NUM
gs-4427	411	2	.	.	PUNCT
gs-4427	412	1	rakoczy	rakoczy	PROPN
gs-4427	412	2	k	k	PROPN
gs-4427	412	3	,	,	PUNCT
gs-4427	412	4	kisielewska	kisielewska	PROPN
gs-4427	412	5	m	m	PROPN
gs-4427	412	6	,	,	PUNCT
gs-4427	412	7	s	s	VERB
gs-4427	412	8	dzik	dzik	NOUN
gs-4427	412	9	m	m	PROPN
gs-4427	412	10	,	,	PUNCT
gs-4427	412	11	jonderko	jonderko	PROPN
gs-4427	412	12	l	l	NOUN
gs-4427	412	13	,	,	PUNCT
gs-4427	412	14	celi	celi	PROPN
gs-4427	412	15	ska	ska	PROPN
gs-4427	412	16	j	j	PROPN
gs-4427	412	17	,	,	PUNCT
gs-4427	412	18	sauer	sauer	PROPN
gs-4427	412	19	n	n	CCONJ
gs-4427	412	20	,	,	PUNCT
gs-4427	412	21	szlasa	szlasa	PROPN
gs-4427	412	22	w	w	PROPN
gs-4427	412	23	,	,	PUNCT
gs-4427	412	24	saczko	saczko	PROPN
gs-4427	412	25	j	j	PROPN
gs-4427	412	26	,	,	PUNCT
gs-4427	412	27	novickij	novickij	PROPN
gs-4427	412	28	v	v	PROPN
gs-4427	412	29	,	,	PUNCT
gs-4427	412	30	kulbacka	kulbacka	PROPN
gs-4427	412	31	j.	j.	PROPN
gs-4427	412	32	electroporation	electroporation	PROPN
gs-4427	412	33	in	in	ADP
gs-4427	412	34	clinical	clinical	ADJ
gs-4427	412	35	applications	application	NOUN
gs-4427	412	36	—	—	PUNCT
gs-4427	412	37	the	the	DET
gs-4427	412	38	potential	potential	NOUN
gs-4427	412	39	of	of	ADP
gs-4427	412	40	gene	gene	NOUN
gs-4427	412	41	electrotransfer	electrotransfer	NOUN
gs-4427	412	42	and	and	CCONJ
gs-4427	412	43	electrochemotherapy	electrochemotherapy	NOUN
gs-4427	412	44	.	.	PUNCT
gs-4427	413	1	appl	appl	PROPN
gs-4427	413	2	sci	sci	PROPN
gs-4427	413	3	.	.	PUNCT
gs-4427	414	1	2022;12(21):10821	2022;12(21):10821	NUM
gs-4427	414	2	.	.	NOUN
gs-4427	415	1	21	21	NUM
gs-4427	415	2	.	.	PUNCT
gs-4427	416	1	przystupski	przystupski	PROPN
gs-4427	416	2	d	d	PROPN
gs-4427	416	3	,	,	PUNCT
gs-4427	416	4	ussowicz	ussowicz	ADJ
gs-4427	416	5	m.	m.	NOUN
gs-4427	416	6	landscape	landscape	NOUN
gs-4427	416	7	of	of	ADP
gs-4427	416	8	cellular	cellular	ADJ
gs-4427	416	9	bioeffects	bioeffect	NOUN
gs-4427	416	10	triggered	trigger	VERB
gs-4427	416	11	by	by	ADP
gs-4427	416	12	ultrasoundinduced	ultrasoundinduced	ADJ
gs-4427	416	13	sonoporation	sonoporation	NOUN
gs-4427	416	14	.	.	PUNCT
gs-4427	417	1	int	int	PROPN
gs-4427	417	2	j	j	PROPN
gs-4427	417	3	mol	mol	ADP
gs-4427	417	4	sci	sci	PROPN
gs-4427	417	5	.	.	PUNCT
gs-4427	418	1	2022;23(19):11222	2022;23(19):11222	NUM
gs-4427	418	2	.	.	NOUN
gs-4427	419	1	22	22	NUM
gs-4427	419	2	.	.	PUNCT
gs-4427	420	1	aphkhazava	aphkhazava	PROPN
gs-4427	420	2	,	,	PUNCT
gs-4427	420	3	d.	d.	PROPN
gs-4427	420	4	,	,	PUNCT
gs-4427	420	5	sulashvili	sulashvili	NOUN
gs-4427	420	6	,	,	PUNCT
gs-4427	420	7	n.	n.	NOUN
gs-4427	420	8	,	,	PUNCT
gs-4427	420	9	egnatievi	egnatievi	PROPN
gs-4427	420	10	,	,	PUNCT
gs-4427	420	11	i.	i.	NOUN
gs-4427	420	12	,	,	PUNCT
gs-4427	420	13	tupinashvili	tupinashvili	NOUN
gs-4427	420	14	,	,	PUNCT
gs-4427	420	15	t.	t.	PROPN
gs-4427	420	16	,	,	PUNCT
gs-4427	420	17	&	&	CCONJ
gs-4427	420	18	nozadze	nozadze	NOUN
gs-4427	420	19	,	,	PUNCT
gs-4427	420	20	m.	m.	NOUN
gs-4427	420	21	(	(	PUNCT
gs-4427	420	22	2024	2024	NUM
gs-4427	420	23	)	)	PUNCT
gs-4427	420	24	.	.	PUNCT
gs-4427	421	1	dynamic	dynamic	ADJ
gs-4427	421	2	tumor	tumor	NOUN
gs-4427	421	3	microenvironment	microenvironment	NOUN
gs-4427	421	4	theory	theory	NOUN
gs-4427	421	5	:	:	PUNCT
gs-4427	421	6	a	a	DET
gs-4427	421	7	multifaceted	multifaceted	ADJ
gs-4427	421	8	approach	approach	NOUN
gs-4427	421	9	to	to	ADP
gs-4427	421	10	tumor	tumor	NOUN
gs-4427	421	11	research	research	NOUN
gs-4427	421	12	and	and	CCONJ
gs-4427	421	13	biochemistry	biochemistry	NOUN
gs-4427	421	14	.	.	PUNCT
gs-4427	422	1	scientific	scientific	ADJ
gs-4427	422	2	journal	journal	NOUN
gs-4427	422	3	„	„	PUNCT
gs-4427	422	4	spectri	spectri	NOUN
gs-4427	422	5	“	"	PUNCT
gs-4427	422	6	,	,	PUNCT
gs-4427	422	7	9(1	9(1	NUM
gs-4427	422	8	)	)	PUNCT
gs-4427	422	9	.	.	PUNCT
gs-4427	423	1	https://doi.org/10.52340/spectri.2024.09.01.06	https://doi.org/10.52340/spectri.2024.09.01.06	ADP
gs-4427	423	2	23	23	NUM
gs-4427	423	3	.	.	PUNCT
gs-4427	424	1	li	li	PROPN
gs-4427	424	2	t	t	PROPN
gs-4427	424	3	,	,	PUNCT
gs-4427	424	4	yang	yang	PROPN
gs-4427	424	5	y	y	PROPN
gs-4427	424	6	,	,	PUNCT
gs-4427	424	7	qi	qi	PROPN
gs-4427	424	8	h	h	NOUN
gs-4427	424	9	,	,	PUNCT
gs-4427	424	10	et	et	PROPN
gs-4427	424	11	al	al	PROPN
gs-4427	424	12	.	.	PROPN
gs-4427	424	13	crispr	crispr	PROPN
gs-4427	424	14	/	/	SYM
gs-4427	424	15	cas9	cas9	NOUN
gs-4427	424	16	therapeutics	therapeutic	NOUN
gs-4427	424	17	:	:	PUNCT
gs-4427	424	18	progress	progress	NOUN
gs-4427	424	19	and	and	CCONJ
gs-4427	424	20	prospects	prospect	NOUN
gs-4427	424	21	.	.	PUNCT
gs-4427	425	1	signal	signal	ADJ
gs-4427	425	2	transduct	transduct	NOUN
gs-4427	425	3	target	target	NOUN
gs-4427	425	4	ther	ther	ADV
gs-4427	425	5	.	.	PUNCT
gs-4427	426	1	2023;8(1):36	2023;8(1):36	NUM
gs-4427	426	2	.	.	NOUN
gs-4427	426	3	24	24	NUM
gs-4427	426	4	.	.	PUNCT
gs-4427	426	5	aljabali	aljabali	ADJ
gs-4427	426	6	aaa	aaa	PROPN
gs-4427	426	7	,	,	PUNCT
gs-4427	426	8	el	el	NOUN
gs-4427	426	9	-	-	PUNCT
gs-4427	426	10	tanani	tanani	PROPN
gs-4427	426	11	m	m	PROPN
gs-4427	426	12	,	,	PUNCT
gs-4427	426	13	tambuwala	tambuwala	PROPN
gs-4427	426	14	mm	mm	INTJ
gs-4427	426	15	.	.	PUNCT
gs-4427	427	1	principles	principle	NOUN
gs-4427	427	2	of	of	ADP
gs-4427	427	3	crispr	crispr	ADJ
gs-4427	427	4	-	-	PUNCT
gs-4427	427	5	cas9	cas9	NOUN
gs-4427	427	6	technology	technology	NOUN
gs-4427	427	7	:	:	PUNCT
gs-4427	427	8	advancements	advancement	NOUN
gs-4427	427	9	in	in	ADP
gs-4427	427	10	genome	genome	NOUN
gs-4427	427	11	editing	editing	NOUN
gs-4427	427	12	and	and	CCONJ
gs-4427	427	13	emerging	emerge	VERB
gs-4427	427	14	trends	trend	NOUN
gs-4427	427	15	in	in	ADP
gs-4427	427	16	drug	drug	NOUN
gs-4427	427	17	delivery	delivery	NOUN
gs-4427	427	18	.	.	PUNCT
gs-4427	428	1	j	j	PROPN
gs-4427	428	2	drug	drug	PROPN
gs-4427	428	3	deliv	deliv	VERB
gs-4427	428	4	sci	sci	PROPN
gs-4427	428	5	technol	technol	NOUN
gs-4427	428	6	.	.	PUNCT
gs-4427	429	1	2024;92:105338	2024;92:105338	NUM
gs-4427	429	2	.	.	NOUN
gs-4427	429	3	25	25	NUM
gs-4427	429	4	.	.	X
gs-4427	429	5	asmamaw	asmamaw	PROPN
gs-4427	429	6	m	m	PROPN
gs-4427	429	7	,	,	PUNCT
gs-4427	429	8	zawdie	zawdie	PROPN
gs-4427	429	9	b.	b.	NOUN
gs-4427	429	10	mechanism	mechanism	NOUN
gs-4427	429	11	and	and	CCONJ
gs-4427	429	12	applications	application	NOUN
gs-4427	429	13	of	of	ADP
gs-4427	429	14	crispr	crispr	NOUN
gs-4427	429	15	/	/	SYM
gs-4427	429	16	cas-9	cas-9	ADV
gs-4427	429	17	-	-	PUNCT
gs-4427	429	18	mediated	mediate	VERB
gs-4427	429	19	genome	genome	NOUN
gs-4427	429	20	editing	editing	NOUN
gs-4427	429	21	.	.	PUNCT
gs-4427	430	1	biologics	biologic	NOUN
gs-4427	430	2	.	.	PUNCT
gs-4427	431	1	2021;15:353–61	2021;15:353–61	NUM
gs-4427	431	2	.	.	PROPN
gs-4427	431	3	26	26	NUM
gs-4427	431	4	.	.	PUNCT
gs-4427	431	5	taha	taha	PROPN
gs-4427	431	6	ea	ea	PROPN
gs-4427	431	7	,	,	PUNCT
gs-4427	431	8	lee	lee	PROPN
gs-4427	431	9	j	j	PROPN
gs-4427	431	10	,	,	PUNCT
gs-4427	431	11	hotta	hotta	ADJ
gs-4427	431	12	a.	a.	NOUN
gs-4427	431	13	delivery	delivery	NOUN
gs-4427	431	14	of	of	ADP
gs-4427	431	15	crispr	crispr	ADJ
gs-4427	431	16	-	-	PUNCT
gs-4427	431	17	cas	cas	NOUN
gs-4427	431	18	tools	tool	NOUN
gs-4427	431	19	for	for	ADP
gs-4427	431	20	in	in	ADP
gs-4427	431	21	vivo	vivo	ADJ
gs-4427	431	22	genome	genome	NOUN
gs-4427	431	23	editing	editing	NOUN
gs-4427	431	24	therapy	therapy	NOUN
gs-4427	431	25	:	:	PUNCT
gs-4427	431	26	trends	trend	NOUN
gs-4427	431	27	and	and	CCONJ
gs-4427	431	28	challenges	challenge	NOUN
gs-4427	431	29	.	.	PUNCT
gs-4427	432	1	j	j	PROPN
gs-4427	432	2	control	control	PROPN
gs-4427	432	3	release	release	PROPN
gs-4427	432	4	.	.	PUNCT
gs-4427	433	1	2022;342:345–61	2022;342:345–61	NUM
gs-4427	433	2	.	.	NOUN
gs-4427	433	3	27	27	NUM
gs-4427	433	4	.	.	PUNCT
gs-4427	433	5	sulashvili	sulashvili	NOUN
gs-4427	433	6	,	,	PUNCT
gs-4427	433	7	n.	n.	NOUN
gs-4427	433	8	,	,	PUNCT
gs-4427	433	9	davitashvili	davitashvili	ADJ
gs-4427	433	10	,	,	PUNCT
gs-4427	433	11	m.	m.	NOUN
gs-4427	433	12	,	,	PUNCT
gs-4427	433	13	gorgaslidze	gorgaslidze	PROPN
gs-4427	433	14	,	,	PUNCT
gs-4427	433	15	n.	n.	NOUN
gs-4427	433	16	,	,	PUNCT
gs-4427	433	17	gabunia	gabunia	NOUN
gs-4427	433	18	,	,	PUNCT
gs-4427	433	19	l.	l.	PROPN
gs-4427	433	20	,	,	PUNCT
gs-4427	433	21	beglaryan	beglaryan	ADJ
gs-4427	433	22	,	,	PUNCT
gs-4427	433	23	m.	m.	NOUN
gs-4427	433	24	,	,	PUNCT
gs-4427	433	25	alavidze	alavidze	NOUN
gs-4427	433	26	,	,	PUNCT
gs-4427	433	27	n.	n.	NOUN
gs-4427	433	28	,	,	PUNCT
gs-4427	433	29	sulashvili	sulashvili	NOUN
gs-4427	433	30	,	,	PUNCT
gs-4427	433	31	m.	m.	NOUN
gs-4427	433	32	(	(	PUNCT
gs-4427	433	33	2024	2024	NUM
gs-4427	433	34	)	)	PUNCT
gs-4427	433	35	.	.	PUNCT
gs-4427	434	1	the	the	DET
gs-4427	434	2	scientific	scientific	ADJ
gs-4427	434	3	discussion	discussion	NOUN
gs-4427	434	4	of	of	ADP
gs-4427	434	5	some	some	DET
gs-4427	434	6	issues	issue	NOUN
gs-4427	434	7	of	of	ADP
gs-4427	434	8	features	feature	NOUN
gs-4427	434	9	and	and	CCONJ
gs-4427	434	10	challenges	challenge	NOUN
gs-4427	434	11	of	of	ADP
gs-4427	434	12	using	use	VERB
gs-4427	434	13	of	of	ADP
gs-4427	434	14	car	car	NOUN
gs-4427	434	15	-	-	PUNCT
gs-4427	434	16	t	t	NOUN
gs-4427	434	17	cells	cell	NOUN
gs-4427	434	18	in	in	ADP
gs-4427	434	19	immunotherapy	immunotherapy	NOUN
gs-4427	434	20	.	.	PUNCT
gs-4427	435	1	georgian	georgian	ADJ
gs-4427	435	2	scientists	scientist	NOUN
gs-4427	435	3	,	,	PUNCT
gs-4427	435	4	6(4	6(4	NOUN
gs-4427	435	5	)	)	PUNCT
gs-4427	435	6	,	,	PUNCT
gs-4427	435	7	263	263	NUM
gs-4427	435	8	–	–	SYM
gs-4427	435	9	290	290	NUM
gs-4427	435	10	.	.	PUNCT
gs-4427	436	1	https://doi.org/10.52340/gs.2024.06.04.24	https://doi.org/10.52340/gs.2024.06.04.24	NOUN
gs-4427	436	2	georgian	georgian	NOUN
gs-4427	436	3	scientists/	scientists/	NUM
gs-4427	436	4	.	.	PUNCT
gs-4427	437	1	7	7	NUM
gs-4427	437	2	n	n	DET
gs-4427	437	3	4	4	NUM
gs-4427	437	4	,	,	PUNCT
gs-4427	437	5	2025	2025	NUM
gs-4427	437	6	655	655	NUM
gs-4427	437	7	28	28	NUM
gs-4427	437	8	.	.	PUNCT
gs-4427	438	1	karvelis	karvelis	PROPN
gs-4427	438	2	t	t	PROPN
gs-4427	438	3	,	,	PUNCT
gs-4427	438	4	gasiunas	gasiuna	VERB
gs-4427	438	5	g	g	NOUN
gs-4427	438	6	,	,	PUNCT
gs-4427	438	7	miksys	miksys	X
gs-4427	438	8	a	a	PRON
gs-4427	438	9	,	,	PUNCT
gs-4427	438	10	barrangou	barrangou	PROPN
gs-4427	438	11	r	r	PROPN
gs-4427	438	12	,	,	PUNCT
gs-4427	438	13	horvath	horvath	PROPN
gs-4427	438	14	p	p	PROPN
gs-4427	438	15	,	,	PUNCT
gs-4427	438	16	siksnys	siksnys	PROPN
gs-4427	438	17	v.	v.	ADP
gs-4427	438	18	crrna	crrna	VERB
gs-4427	438	19	and	and	CCONJ
gs-4427	438	20	tracrrna	tracrrna	NOUN
gs-4427	438	21	guide	guide	NOUN
gs-4427	438	22	cas9	cas9	NOUN
gs-4427	438	23	-	-	PUNCT
gs-4427	438	24	mediated	mediate	VERB
gs-4427	438	25	dna	dna	NOUN
gs-4427	438	26	interference	interference	NOUN
gs-4427	438	27	in	in	ADP
gs-4427	438	28	streptococcus	streptococcus	NOUN
gs-4427	438	29	thermophilus	thermophilus	NOUN
gs-4427	438	30	.	.	PUNCT
gs-4427	439	1	rna	rna	NOUN
gs-4427	439	2	biol	biol	NOUN
gs-4427	439	3	.	.	PUNCT
gs-4427	440	1	2013;10(5):841–51	2013;10(5):841–51	NUM
gs-4427	440	2	.	.	NOUN
gs-4427	441	1	29	29	NUM
gs-4427	441	2	.	.	PUNCT
gs-4427	442	1	gleditzsch	gleditzsch	PROPN
gs-4427	442	2	d	d	PROPN
gs-4427	442	3	,	,	PUNCT
gs-4427	442	4	pausch	pausch	PROPN
gs-4427	442	5	p	p	NOUN
gs-4427	442	6	,	,	PUNCT
gs-4427	442	7	müller	müller	PROPN
gs-4427	442	8	-	-	PUNCT
gs-4427	442	9	esparza	esparza	PROPN
gs-4427	442	10	h	h	PROPN
gs-4427	442	11	,	,	PUNCT
gs-4427	442	12	et	et	PROPN
gs-4427	442	13	al	al	PROPN
gs-4427	442	14	.	.	PROPN
gs-4427	442	15	pam	pam	PROPN
gs-4427	442	16	identification	identification	NOUN
gs-4427	442	17	by	by	ADP
gs-4427	442	18	crispr	crispr	ADJ
gs-4427	442	19	-	-	PUNCT
gs-4427	442	20	cas	cas	NOUN
gs-4427	442	21	effector	effector	NOUN
gs-4427	442	22	complexes	complex	NOUN
gs-4427	442	23	:	:	PUNCT
gs-4427	442	24	diversified	diversify	VERB
gs-4427	442	25	mechanisms	mechanism	NOUN
gs-4427	442	26	and	and	CCONJ
gs-4427	442	27	structures	structure	NOUN
gs-4427	442	28	.	.	PUNCT
gs-4427	443	1	rna	rna	NOUN
gs-4427	443	2	biol	biol	NOUN
gs-4427	443	3	.	.	PUNCT
gs-4427	444	1	2019;16(4):504	2019;16(4):504	NUM
gs-4427	444	2	–	–	PUNCT
gs-4427	444	3	17	17	NUM
gs-4427	444	4	.	.	NOUN
gs-4427	444	5	30	30	NUM
gs-4427	444	6	.	.	PUNCT
gs-4427	445	1	shi	shi	PROPN
gs-4427	445	2	y	y	PROPN
gs-4427	445	3	-	-	PUNCT
gs-4427	445	4	j	j	PROPN
gs-4427	445	5	,	,	PUNCT
gs-4427	445	6	duan	duan	PROPN
gs-4427	445	7	m	m	PROPN
gs-4427	445	8	,	,	PUNCT
gs-4427	445	9	ding	de	VERB
gs-4427	445	10	j	j	PROPN
gs-4427	445	11	-	-	PROPN
gs-4427	445	12	m	m	PROPN
gs-4427	445	13	,	,	PUNCT
gs-4427	445	14	et	et	PROPN
gs-4427	445	15	al	al	PROPN
gs-4427	445	16	.	.	PROPN
gs-4427	446	1	dna	dna	PROPN
gs-4427	446	2	topology	topology	PROPN
gs-4427	446	3	regulates	regulate	VERB
gs-4427	446	4	pam	pam	NOUN
gs-4427	446	5	-	-	PUNCT
gs-4427	446	6	cas9	cas9	NOUN
gs-4427	446	7	interaction	interaction	NOUN
gs-4427	446	8	and	and	CCONJ
gs-4427	446	9	dna	dna	NOUN
gs-4427	446	10	unwinding	unwind	VERB
gs-4427	446	11	to	to	PART
gs-4427	446	12	enable	enable	VERB
gs-4427	446	13	near	near	ADJ
gs-4427	446	14	-	-	PUNCT
gs-4427	446	15	pamless	pamless	NOUN
gs-4427	446	16	cleavage	cleavage	NOUN
gs-4427	446	17	by	by	ADP
gs-4427	446	18	thermophilic	thermophilic	ADJ
gs-4427	446	19	cas9	cas9	NOUN
gs-4427	446	20	.	.	PUNCT
gs-4427	447	1	mol	mol	ADP
gs-4427	447	2	cell	cell	NOUN
gs-4427	447	3	.	.	PUNCT
gs-4427	448	1	2022;82(21):4160	2022;82(21):4160	NUM
gs-4427	448	2	-	-	NOUN
gs-4427	448	3	4175.e4166	4175.e4166	NOUN
gs-4427	448	4	.	.	PUNCT
gs-4427	449	1	31	31	NUM
gs-4427	449	2	.	.	PUNCT
gs-4427	450	1	uddin	uddin	PROPN
gs-4427	450	2	f	f	PROPN
gs-4427	450	3	,	,	PUNCT
gs-4427	450	4	rudin	rudin	PROPN
gs-4427	450	5	cm	cm	PROPN
gs-4427	450	6	,	,	PUNCT
gs-4427	450	7	sen	sen	PROPN
gs-4427	450	8	t.	t.	PROPN
gs-4427	450	9	crispr	crispr	PROPN
gs-4427	450	10	gene	gene	NOUN
gs-4427	450	11	therapy	therapy	NOUN
gs-4427	450	12	:	:	PUNCT
gs-4427	450	13	applications	application	NOUN
gs-4427	450	14	,	,	PUNCT
gs-4427	450	15	limitations	limitation	NOUN
gs-4427	450	16	,	,	PUNCT
gs-4427	450	17	and	and	CCONJ
gs-4427	450	18	implications	implication	NOUN
gs-4427	450	19	for	for	ADP
gs-4427	450	20	the	the	DET
gs-4427	450	21	future	future	NOUN
gs-4427	450	22	.	.	PUNCT
gs-4427	451	1	front	front	ADJ
gs-4427	451	2	oncol	oncol	ADJ
gs-4427	451	3	.	.	PUNCT
gs-4427	452	1	2020;10:1387	2020;10:1387	NUM
gs-4427	452	2	.	.	NOUN
gs-4427	452	3	32	32	NUM
gs-4427	452	4	.	.	PUNCT
gs-4427	453	1	ghahri	ghahri	PROPN
gs-4427	453	2	-	-	PUNCT
gs-4427	453	3	saremi	saremi	PROPN
gs-4427	453	4	n	n	CCONJ
gs-4427	453	5	,	,	PUNCT
gs-4427	453	6	akbari	akbari	PROPN
gs-4427	453	7	b	b	PROPN
gs-4427	453	8	,	,	PUNCT
gs-4427	453	9	soltantoyeh	soltantoyeh	PROPN
gs-4427	453	10	t	t	PROPN
gs-4427	453	11	,	,	PUNCT
gs-4427	453	12	hadjati	hadjati	PROPN
gs-4427	453	13	j	j	PROPN
gs-4427	453	14	,	,	PUNCT
gs-4427	453	15	ghassemi	ghassemi	PROPN
gs-4427	453	16	s	s	SYM
gs-4427	453	17	,	,	PUNCT
gs-4427	453	18	mirzaei	mirzaei	ADJ
gs-4427	453	19	hr	hr	PROPN
gs-4427	453	20	.	.	PUNCT
gs-4427	454	1	genetic	genetic	ADJ
gs-4427	454	2	modification	modification	NOUN
gs-4427	454	3	of	of	ADP
gs-4427	454	4	cytokine	cytokine	NOUN
gs-4427	454	5	signaling	signal	VERB
gs-4427	454	6	to	to	PART
gs-4427	454	7	enhance	enhance	VERB
gs-4427	454	8	efficacy	efficacy	NOUN
gs-4427	454	9	of	of	ADP
gs-4427	454	10	car	car	NOUN
gs-4427	454	11	t	t	NOUN
gs-4427	454	12	cell	cell	NOUN
gs-4427	454	13	therapy	therapy	NOUN
gs-4427	454	14	in	in	ADP
gs-4427	454	15	solid	solid	ADJ
gs-4427	454	16	tumors	tumor	NOUN
gs-4427	454	17	.	.	PUNCT
gs-4427	455	1	front	front	ADJ
gs-4427	455	2	.	.	PUNCT
gs-4427	456	1	immunol	immunol	NOUN
gs-4427	456	2	2021;12:738456	2021;12:738456	PROPN
gs-4427	456	3	.	.	PUNCT
gs-4427	457	1	33	33	NUM
gs-4427	457	2	.	.	PUNCT
gs-4427	458	1	asmamawdejenie	asmamawdejenie	PROPN
gs-4427	458	2	t	t	PROPN
gs-4427	458	3	,	,	PUNCT
gs-4427	458	4	tiruneh	tiruneh	PROPN
gs-4427	458	5	gmm	gmm	PROPN
gs-4427	458	6	,	,	PUNCT
gs-4427	458	7	dessie	dessie	PROPN
gs-4427	458	8	terefe	terefe	PROPN
gs-4427	458	9	g	g	PROPN
gs-4427	458	10	,	,	PUNCT
gs-4427	458	11	tadeleadmasu	tadeleadmasu	NOUN
gs-4427	458	12	f	f	PROPN
gs-4427	458	13	,	,	PUNCT
gs-4427	458	14	wale	wale	PROPN
gs-4427	458	15	tesega	tesega	PROPN
gs-4427	458	16	w	w	PROPN
gs-4427	458	17	,	,	PUNCT
gs-4427	458	18	chekol	chekol	NOUN
gs-4427	458	19	ae	ae	PROPN
gs-4427	458	20	.	.	PUNCT
gs-4427	459	1	current	current	ADJ
gs-4427	459	2	updates	update	NOUN
gs-4427	459	3	on	on	ADP
gs-4427	459	4	generations	generation	NOUN
gs-4427	459	5	,	,	PUNCT
gs-4427	459	6	approvals	approval	NOUN
gs-4427	459	7	,	,	PUNCT
gs-4427	459	8	and	and	CCONJ
gs-4427	459	9	clinical	clinical	ADJ
gs-4427	459	10	trials	trial	NOUN
gs-4427	459	11	of	of	ADP
gs-4427	459	12	car	car	NOUN
gs-4427	459	13	tcell	tcell	NOUN
gs-4427	459	14	therapy	therapy	NOUN
gs-4427	459	15	.	.	PUNCT
gs-4427	460	1	hum	hum	PROPN
gs-4427	460	2	vaccin	vaccin	PROPN
gs-4427	460	3	immunother	immunother	PROPN
gs-4427	460	4	.	.	PUNCT
gs-4427	461	1	2022;18(6):2114254	2022;18(6):2114254	NUM
gs-4427	461	2	.	.	PUNCT
gs-4427	462	1	34	34	NUM
gs-4427	462	2	.	.	PUNCT
gs-4427	463	1	ahmad	ahmad	PROPN
gs-4427	463	2	u	u	PROPN
gs-4427	463	3	,	,	PUNCT
gs-4427	463	4	khan	khan	PROPN
gs-4427	463	5	z	z	PROPN
gs-4427	463	6	,	,	PUNCT
gs-4427	463	7	ualiyeva	ualiyeva	PROPN
gs-4427	463	8	d	d	PROPN
gs-4427	463	9	,	,	PUNCT
gs-4427	463	10	et	et	PROPN
gs-4427	463	11	al	al	PROPN
gs-4427	463	12	.	.	PROPN
gs-4427	463	13	chimeric	chimeric	ADJ
gs-4427	463	14	antigen	antigen	ADJ
gs-4427	463	15	receptor	receptor	NOUN
gs-4427	463	16	t	t	NOUN
gs-4427	463	17	cell	cell	NOUN
gs-4427	463	18	structure	structure	NOUN
gs-4427	463	19	,	,	PUNCT
gs-4427	463	20	its	its	PRON
gs-4427	463	21	manufacturing	manufacturing	NOUN
gs-4427	463	22	,	,	PUNCT
gs-4427	463	23	and	and	CCONJ
gs-4427	463	24	related	related	ADJ
gs-4427	463	25	toxicities	toxicity	NOUN
gs-4427	463	26	;	;	PUNCT
gs-4427	463	27	a	a	DET
gs-4427	463	28	comprehensive	comprehensive	ADJ
gs-4427	463	29	review	review	NOUN
gs-4427	463	30	.	.	PUNCT
gs-4427	464	1	adv	adv	PROPN
gs-4427	464	2	cancer	cancer	NOUN
gs-4427	464	3	biol	biol	PROPN
gs-4427	464	4	metastasis	metastasis	NOUN
gs-4427	464	5	.	.	PUNCT
gs-4427	465	1	2022;4:100035	2022;4:100035	NUM
gs-4427	465	2	.	.	NOUN
gs-4427	466	1	35	35	NUM
gs-4427	466	2	.	.	PUNCT
gs-4427	467	1	hyun	hyun	PROPN
gs-4427	467	2	j	j	PROPN
gs-4427	467	3	-	-	PUNCT
gs-4427	467	4	w	w	PROPN
gs-4427	467	5	,	,	PUNCT
gs-4427	467	6	lee	lee	PROPN
gs-4427	467	7	k	k	PROPN
gs-4427	467	8	,	,	PUNCT
gs-4427	467	9	kim	kim	PROPN
gs-4427	467	10	j	j	PROPN
gs-4427	467	11	-	-	PROPN
gs-4427	467	12	h	h	PROPN
gs-4427	467	13	,	,	PUNCT
gs-4427	467	14	et	et	PROPN
gs-4427	467	15	al	al	PROPN
gs-4427	467	16	.	.	PROPN
gs-4427	467	17	extracellular	extracellular	ADJ
gs-4427	467	18	production	production	NOUN
gs-4427	467	19	of	of	ADP
gs-4427	467	20	an	an	DET
gs-4427	467	21	anti	anti	ADJ
gs-4427	467	22	-	-	ADJ
gs-4427	467	23	her2	her2	ADJ
gs-4427	467	24	single	single	ADJ
gs-4427	467	25	-	-	PUNCT
gs-4427	467	26	chain	chain	NOUN
gs-4427	467	27	variable	variable	ADJ
gs-4427	467	28	antibody	antibody	NOUN
gs-4427	467	29	fragment	fragment	NOUN
gs-4427	467	30	in	in	ADP
gs-4427	467	31	escherichia	escherichia	NOUN
gs-4427	467	32	coli	coli	NOUN
gs-4427	467	33	.	.	PUNCT
gs-4427	468	1	process	process	NOUN
gs-4427	468	2	biochem	biochem	NOUN
gs-4427	468	3	.	.	PUNCT
gs-4427	469	1	2021;111:87–94	2021;111:87–94	X
gs-4427	469	2	.	.	X
gs-4427	470	1	36	36	NUM
gs-4427	470	2	.	.	PUNCT
gs-4427	471	1	huang	huang	PROPN
gs-4427	471	2	y	y	PROPN
gs-4427	471	3	,	,	PUNCT
gs-4427	471	4	li	li	PROPN
gs-4427	471	5	l	l	PROPN
gs-4427	471	6	,	,	PUNCT
gs-4427	471	7	liu	liu	PROPN
gs-4427	471	8	w	w	PROPN
gs-4427	471	9	,	,	PUNCT
gs-4427	471	10	tang	tang	PROPN
gs-4427	471	11	t	t	PROPN
gs-4427	471	12	,	,	PUNCT
gs-4427	471	13	chen	chen	PROPN
gs-4427	471	14	l.	l.	PROPN
gs-4427	471	15	the	the	DET
gs-4427	471	16	progress	progress	NOUN
gs-4427	471	17	of	of	ADP
gs-4427	471	18	car	car	NOUN
gs-4427	471	19	-	-	PUNCT
gs-4427	471	20	t	t	NOUN
gs-4427	471	21	therapy	therapy	NOUN
gs-4427	471	22	in	in	ADP
gs-4427	471	23	cancer	cancer	NOUN
gs-4427	471	24	and	and	CCONJ
gs-4427	471	25	beyond	beyond	ADP
gs-4427	471	26	.	.	PUNCT
gs-4427	471	27	stemedicine	stemedicine	NOUN
gs-4427	471	28	.	.	PUNCT
gs-4427	472	1	2020;1(3):e47	2020;1(3):e47	NUM
gs-4427	472	2	.	.	PROPN
gs-4427	473	1	37	37	NUM
gs-4427	473	2	.	.	PUNCT
gs-4427	474	1	ramos	ramos	PROPN
gs-4427	474	2	ca	ca	PROPN
gs-4427	474	3	,	,	PUNCT
gs-4427	474	4	savoldo	savoldo	PROPN
gs-4427	474	5	b	b	PROPN
gs-4427	474	6	,	,	PUNCT
gs-4427	474	7	dotti	dotti	PROPN
gs-4427	474	8	g.	g.	PROPN
gs-4427	474	9	cd19	cd19	PROPN
gs-4427	474	10	-	-	PUNCT
gs-4427	474	11	car	car	NOUN
gs-4427	474	12	trials	trial	NOUN
gs-4427	474	13	.	.	PUNCT
gs-4427	475	1	cancer	cancer	NOUN
gs-4427	475	2	j.	j.	PROPN
gs-4427	475	3	2014;20(2):112–8	2014;20(2):112–8	PROPN
gs-4427	475	4	.	.	PUNCT
gs-4427	476	1	38	38	NUM
gs-4427	476	2	.	.	PUNCT
gs-4427	477	1	harrison	harrison	PROPN
gs-4427	477	2	aj	aj	PROPN
gs-4427	477	3	,	,	PUNCT
gs-4427	477	4	du	du	PROPN
gs-4427	477	5	x	x	PROPN
gs-4427	477	6	,	,	PUNCT
gs-4427	477	7	von	von	PROPN
gs-4427	477	8	scheidt	scheidt	PROPN
gs-4427	477	9	b	b	PROPN
gs-4427	477	10	,	,	PUNCT
gs-4427	477	11	kershaw	kershaw	PROPN
gs-4427	477	12	mh	mh	PROPN
gs-4427	477	13	,	,	PUNCT
gs-4427	477	14	slaney	slaney	PROPN
gs-4427	477	15	cy	cy	AUX
gs-4427	477	16	.	.	PROPN
gs-4427	477	17	enhancing	enhance	VERB
gs-4427	477	18	co	co	NOUN
gs-4427	477	19	-	-	NOUN
gs-4427	477	20	stimulation	stimulation	NOUN
gs-4427	477	21	of	of	ADP
gs-4427	477	22	car	car	NOUN
gs-4427	477	23	t	t	NOUN
gs-4427	477	24	cells	cell	NOUN
gs-4427	477	25	to	to	PART
gs-4427	477	26	improve	improve	VERB
gs-4427	477	27	treatment	treatment	NOUN
gs-4427	477	28	outcomes	outcome	NOUN
gs-4427	477	29	in	in	ADP
gs-4427	477	30	solid	solid	ADJ
gs-4427	477	31	cancers	cancer	NOUN
gs-4427	477	32	.	.	PUNCT
gs-4427	478	1	immunother	immunother	PROPN
gs-4427	478	2	adv	adv	PROPN
gs-4427	478	3	.	.	PUNCT
gs-4427	478	4	2021;1(1):ltab016	2021;1(1):ltab016	NUM
gs-4427	478	5	.	.	X
gs-4427	479	1	39	39	NUM
gs-4427	479	2	.	.	PUNCT
gs-4427	480	1	sterner	sterner	PROPN
gs-4427	480	2	rc	rc	PROPN
gs-4427	480	3	,	,	PUNCT
gs-4427	480	4	sterner	sterner	PROPN
gs-4427	480	5	rm	rm	PROPN
gs-4427	480	6	.	.	PUNCT
gs-4427	480	7	car	car	PROPN
gs-4427	480	8	-	-	PUNCT
gs-4427	480	9	t	t	PROPN
gs-4427	480	10	cell	cell	NOUN
gs-4427	480	11	therapy	therapy	NOUN
gs-4427	480	12	:	:	PUNCT
gs-4427	480	13	current	current	ADJ
gs-4427	480	14	limitations	limitation	NOUN
gs-4427	480	15	and	and	CCONJ
gs-4427	480	16	potential	potential	ADJ
gs-4427	480	17	strategies	strategy	NOUN
gs-4427	480	18	.	.	PUNCT
gs-4427	481	1	blood	blood	NOUN
gs-4427	481	2	cancer	cancer	NOUN
gs-4427	481	3	j.	j.	PROPN
gs-4427	481	4	2021;11(4):69	2021;11(4):69	PROPN
gs-4427	481	5	.	.	PROPN
gs-4427	482	1	40	40	NUM
gs-4427	482	2	.	.	PUNCT
gs-4427	483	1	kandra	kandra	PROPN
gs-4427	483	2	p	p	NOUN
gs-4427	483	3	,	,	PUNCT
gs-4427	483	4	nandigama	nandigama	NOUN
gs-4427	483	5	r	r	NOUN
gs-4427	483	6	,	,	PUNCT
gs-4427	483	7	eul	eul	NOUN
gs-4427	483	8	b	b	NOUN
gs-4427	483	9	,	,	PUNCT
gs-4427	483	10	et	et	PROPN
gs-4427	483	11	al	al	PROPN
gs-4427	483	12	.	.	PUNCT
gs-4427	483	13	utility	utility	NOUN
gs-4427	483	14	and	and	CCONJ
gs-4427	483	15	drawbacks	drawback	NOUN
gs-4427	483	16	of	of	ADP
gs-4427	483	17	chimeric	chimeric	ADJ
gs-4427	483	18	antigen	antigen	ADJ
gs-4427	483	19	receptor	receptor	NOUN
gs-4427	483	20	t	t	NOUN
gs-4427	483	21	cell	cell	NOUN
gs-4427	483	22	(	(	PUNCT
gs-4427	483	23	car	car	NOUN
gs-4427	483	24	-	-	PUNCT
gs-4427	483	25	t	t	NOUN
gs-4427	483	26	)	)	PUNCT
gs-4427	483	27	therapy	therapy	NOUN
gs-4427	483	28	in	in	ADP
gs-4427	483	29	lung	lung	NOUN
gs-4427	483	30	cancer	cancer	NOUN
gs-4427	483	31	.	.	PUNCT
gs-4427	484	1	front	front	ADJ
gs-4427	484	2	immunol	immunol	NOUN
gs-4427	484	3	.	.	PUNCT
gs-4427	485	1	2022;13:903562	2022;13:903562	NUM
gs-4427	485	2	.	.	NOUN
gs-4427	485	3	41	41	NUM
gs-4427	485	4	.	.	PUNCT
gs-4427	485	5	stone	stone	PROPN
gs-4427	485	6	jb	jb	PROPN
gs-4427	485	7	,	,	PUNCT
gs-4427	485	8	deangelis	deangelis	PROPN
gs-4427	485	9	lm	lm	PROPN
gs-4427	485	10	.	.	PUNCT
gs-4427	486	1	cancer	cancer	NOUN
gs-4427	486	2	-	-	PUNCT
gs-4427	486	3	treatment	treatment	NOUN
gs-4427	486	4	-	-	PUNCT
gs-4427	486	5	induced	induce	VERB
gs-4427	486	6	neurotoxicity	neurotoxicity	NOUN
gs-4427	486	7	–	–	PUNCT
gs-4427	486	8	focus	focus	NOUN
gs-4427	486	9	on	on	ADP
gs-4427	486	10	newer	new	ADJ
gs-4427	486	11	treatments	treatment	NOUN
gs-4427	486	12	.	.	PUNCT
gs-4427	487	1	nat	nat	PROPN
gs-4427	487	2	rev	rev	VERB
gs-4427	487	3	clin	clin	PROPN
gs-4427	487	4	oncol	oncol	PROPN
gs-4427	487	5	.	.	PUNCT
gs-4427	488	1	2016;13(2):92–105	2016;13(2):92–105	NOUN
gs-4427	488	2	.	.	PUNCT
gs-4427	489	1	42	42	NUM
gs-4427	489	2	.	.	PUNCT
gs-4427	490	1	castaman	castaman	PROPN
gs-4427	490	2	g	g	PROPN
gs-4427	490	3	,	,	PUNCT
gs-4427	490	4	motlagh	motlagh	ADJ
gs-4427	490	5	h	h	NOUN
gs-4427	490	6	,	,	PUNCT
gs-4427	490	7	pezeshkpoor	pezeshkpoor	PROPN
gs-4427	490	8	b.	b.	PROPN
gs-4427	491	1	hemophilia	hemophilia	PROPN
gs-4427	492	1	b	b	X
gs-4427	492	2	:	:	PUNCT
gs-4427	492	3	diagnosis	diagnosis	NOUN
gs-4427	492	4	and	and	CCONJ
gs-4427	492	5	management	management	NOUN
gs-4427	492	6	.	.	PUNCT
gs-4427	493	1	in	in	ADP
gs-4427	493	2	:	:	PUNCT
gs-4427	493	3	dorgalaleh	dorgalaleh	NOUN
gs-4427	493	4	a	a	PRON
gs-4427	493	5	,	,	PUNCT
gs-4427	493	6	editor	editor	NOUN
gs-4427	493	7	.	.	PUNCT
gs-4427	494	1	congenital	congenital	ADJ
gs-4427	494	2	bleeding	bleeding	NOUN
gs-4427	494	3	disorders	disorder	NOUN
gs-4427	494	4	:	:	PUNCT
gs-4427	494	5	diagnosis	diagnosis	NOUN
gs-4427	494	6	and	and	CCONJ
gs-4427	494	7	management	management	NOUN
gs-4427	494	8	.	.	PUNCT
gs-4427	495	1	cham	cham	PROPN
gs-4427	495	2	:	:	PUNCT
gs-4427	495	3	springer	springer	NOUN
gs-4427	495	4	international	international	ADJ
gs-4427	495	5	publishing	publishing	NOUN
gs-4427	495	6	;	;	PUNCT
gs-4427	495	7	2023	2023	NUM
gs-4427	495	8	.	.	PUNCT
gs-4427	496	1	145–171	145–171	NUM
gs-4427	496	2	.	.	NOUN
gs-4427	497	1	43	43	NUM
gs-4427	497	2	.	.	PUNCT
gs-4427	498	1	ozelo	ozelo	PROPN
gs-4427	498	2	mc	mc	PROPN
gs-4427	498	3	,	,	PUNCT
gs-4427	498	4	mahlangu	mahlangu	PROPN
gs-4427	498	5	j	j	PROPN
gs-4427	498	6	,	,	PUNCT
gs-4427	498	7	pasi	pasi	PROPN
gs-4427	498	8	kj	kj	PROPN
gs-4427	498	9	,	,	PUNCT
gs-4427	498	10	et	et	PROPN
gs-4427	498	11	al	al	PROPN
gs-4427	498	12	.	.	PROPN
gs-4427	498	13	valoctocogene	valoctocogene	PROPN
gs-4427	498	14	roxaparvovec	roxaparvovec	PROPN
gs-4427	498	15	gene	gene	NOUN
gs-4427	498	16	therapy	therapy	NOUN
gs-4427	498	17	for	for	ADP
gs-4427	498	18	hemophilia	hemophilia	NOUN
gs-4427	498	19	a.	a.	NOUN
gs-4427	498	20	n	n	PROPN
gs-4427	498	21	engl	engl	PROPN
gs-4427	498	22	j	j	PROPN
gs-4427	498	23	med	med	PROPN
gs-4427	498	24	.	.	PUNCT
gs-4427	499	1	2022;386(11):1013–25	2022;386(11):1013–25	NUM
gs-4427	499	2	.	.	PUNCT
gs-4427	500	1	georgian	georgian	NOUN
gs-4427	500	2	scientists/	scientists/	NUM
gs-4427	500	3	.	.	PUNCT
gs-4427	501	1	7	7	NUM
gs-4427	501	2	n	n	DET
gs-4427	501	3	4	4	NUM
gs-4427	501	4	,	,	PUNCT
gs-4427	501	5	2025	2025	NUM
gs-4427	501	6	656	656	NUM
gs-4427	501	7	44	44	NUM
gs-4427	501	8	.	.	PUNCT
gs-4427	502	1	konkle	konkle	VERB
gs-4427	502	2	ba	ba	PROPN
gs-4427	502	3	,	,	PUNCT
gs-4427	502	4	walsh	walsh	PROPN
gs-4427	502	5	ce	ce	PROPN
gs-4427	502	6	,	,	PUNCT
gs-4427	502	7	escobar	escobar	PROPN
gs-4427	502	8	ma	ma	PROPN
gs-4427	502	9	,	,	PUNCT
gs-4427	502	10	et	et	PROPN
gs-4427	502	11	al	al	PROPN
gs-4427	502	12	.	.	PUNCT
gs-4427	503	1	bax	bax	PROPN
gs-4427	503	2	335	335	NUM
gs-4427	503	3	hemophilia	hemophilia	PROPN
gs-4427	503	4	b	b	NOUN
gs-4427	503	5	gene	gene	NOUN
gs-4427	503	6	therapy	therapy	NOUN
gs-4427	503	7	clinical	clinical	ADJ
gs-4427	503	8	trial	trial	NOUN
gs-4427	503	9	results	result	NOUN
gs-4427	503	10	:	:	PUNCT
gs-4427	503	11	potential	potential	ADJ
gs-4427	503	12	impact	impact	NOUN
gs-4427	503	13	of	of	ADP
gs-4427	503	14	cpg	cpg	NOUN
gs-4427	503	15	sequences	sequence	NOUN
gs-4427	503	16	on	on	ADP
gs-4427	503	17	gene	gene	NOUN
gs-4427	503	18	expression	expression	NOUN
gs-4427	503	19	.	.	PUNCT
gs-4427	504	1	blood	blood	NOUN
gs-4427	504	2	.	.	PUNCT
gs-4427	505	1	2021;137(6):763–74	2021;137(6):763–74	NUM
gs-4427	505	2	.	.	X
gs-4427	506	1	45	45	NUM
gs-4427	506	2	.	.	PUNCT
gs-4427	507	1	uddin	uddin	PROPN
gs-4427	507	2	f	f	PROPN
gs-4427	507	3	,	,	PUNCT
gs-4427	507	4	rudin	rudin	PROPN
gs-4427	507	5	cm	cm	PROPN
gs-4427	507	6	,	,	PUNCT
gs-4427	507	7	sen	sen	PROPN
gs-4427	507	8	t.	t.	PROPN
gs-4427	507	9	crispr	crispr	PROPN
gs-4427	507	10	gene	gene	NOUN
gs-4427	507	11	therapy	therapy	NOUN
gs-4427	507	12	:	:	PUNCT
gs-4427	507	13	applications	application	NOUN
gs-4427	507	14	,	,	PUNCT
gs-4427	507	15	limitations	limitation	NOUN
gs-4427	507	16	,	,	PUNCT
gs-4427	507	17	and	and	CCONJ
gs-4427	507	18	implications	implication	NOUN
gs-4427	507	19	for	for	ADP
gs-4427	507	20	the	the	DET
gs-4427	507	21	future	future	NOUN
gs-4427	507	22	.	.	PUNCT
gs-4427	508	1	frontiers	frontier	NOUN
gs-4427	508	2	in	in	ADP
gs-4427	508	3	oncology	oncology	NOUN
gs-4427	508	4	.	.	PUNCT
gs-4427	509	1	2020	2020	NUM
gs-4427	509	2	aug	aug	PROPN
gs-4427	509	3	7;10:1387	7;10:1387	NUM
gs-4427	509	4	.	.	PUNCT
gs-4427	510	1	46	46	NUM
gs-4427	510	2	.	.	PUNCT
gs-4427	511	1	chowdary	chowdary	PROPN
gs-4427	511	2	p	p	PROPN
gs-4427	511	3	,	,	PUNCT
gs-4427	511	4	shapiro	shapiro	PROPN
gs-4427	511	5	s	s	PROPN
gs-4427	511	6	,	,	PUNCT
gs-4427	511	7	makris	makris	VERB
gs-4427	511	8	m	m	PROPN
gs-4427	511	9	,	,	PUNCT
gs-4427	511	10	et	et	PROPN
gs-4427	511	11	al	al	PROPN
gs-4427	511	12	.	.	PROPN
gs-4427	511	13	phase	phase	NOUN
gs-4427	511	14	1–2	1–2	DET
gs-4427	511	15	trial	trial	NOUN
gs-4427	511	16	of	of	ADP
gs-4427	511	17	aavs3	aavs3	NOUN
gs-4427	511	18	gene	gene	NOUN
gs-4427	511	19	therapy	therapy	NOUN
gs-4427	511	20	in	in	ADP
gs-4427	511	21	patients	patient	NOUN
gs-4427	511	22	with	with	ADP
gs-4427	511	23	hemophilia	hemophilia	PROPN
gs-4427	511	24	b.	b.	PROPN
gs-4427	511	25	n	n	PROPN
gs-4427	511	26	engl	engl	PROPN
gs-4427	511	27	j	j	PROPN
gs-4427	511	28	med	med	PROPN
gs-4427	511	29	.	.	PUNCT
gs-4427	512	1	2022;387(3):237–47	2022;387(3):237–47	X
gs-4427	512	2	.	.	PROPN
gs-4427	513	1	47	47	NUM
gs-4427	513	2	.	.	PUNCT
gs-4427	513	3	sulashvili	sulashvili	NOUN
gs-4427	513	4	,	,	PUNCT
gs-4427	513	5	n.	n.	NOUN
gs-4427	513	6	,	,	PUNCT
gs-4427	513	7	khusseyn	khusseyn	NOUN
gs-4427	513	8	,	,	PUNCT
gs-4427	513	9	v.	v.	PROPN
gs-4427	513	10	,	,	PUNCT
gs-4427	513	11	hussin	hussin	PROPN
gs-4427	513	12	,	,	PUNCT
gs-4427	513	13	d.	d.	PROPN
gs-4427	513	14	,	,	PUNCT
gs-4427	513	15	gabunia	gabunia	PROPN
gs-4427	513	16	,	,	PUNCT
gs-4427	513	17	l.	l.	PROPN
gs-4427	513	18	,	,	PUNCT
gs-4427	513	19	gorgaslidze	gorgaslidze	PROPN
gs-4427	513	20	,	,	PUNCT
gs-4427	513	21	n.	n.	NOUN
gs-4427	513	22	,	,	PUNCT
gs-4427	513	23	sulashvili	sulashvili	NOUN
gs-4427	513	24	,	,	PUNCT
gs-4427	513	25	m.	m.	NOUN
gs-4427	513	26	,	,	PUNCT
gs-4427	513	27	aphkhazava	aphkhazava	PROPN
gs-4427	513	28	,	,	PUNCT
gs-4427	513	29	d.	d.	PROPN
gs-4427	513	30	(	(	PUNCT
gs-4427	513	31	2025	2025	NUM
gs-4427	513	32	)	)	PUNCT
gs-4427	513	33	.	.	PUNCT
gs-4427	514	1	the	the	DET
gs-4427	514	2	scientific	scientific	ADJ
gs-4427	514	3	talks	talk	NOUN
gs-4427	514	4	of	of	ADP
gs-4427	514	5	manifestation	manifestation	NOUN
gs-4427	514	6	of	of	ADP
gs-4427	514	7	exosomes	exosome	NOUN
gs-4427	514	8	and	and	CCONJ
gs-4427	514	9	small	small	ADJ
gs-4427	514	10	particle	particle	NOUN
gs-4427	514	11	-	-	PUNCT
gs-4427	514	12	based	base	VERB
gs-4427	514	13	therapeutics	therapeutic	NOUN
gs-4427	514	14	:	:	PUNCT
gs-4427	514	15	a	a	DET
gs-4427	514	16	comparative	comparative	ADJ
gs-4427	514	17	review	review	NOUN
gs-4427	514	18	of	of	ADP
gs-4427	514	19	biological	biological	ADJ
gs-4427	514	20	and	and	CCONJ
gs-4427	514	21	synthetic	synthetic	ADJ
gs-4427	514	22	nanocarriers	nanocarrier	NOUN
gs-4427	514	23	.	.	PUNCT
gs-4427	515	1	georgian	georgian	ADJ
gs-4427	515	2	scientists	scientist	NOUN
gs-4427	515	3	,	,	PUNCT
gs-4427	515	4	7(4	7(4	NUM
gs-4427	515	5	)	)	PUNCT
gs-4427	515	6	,	,	PUNCT
gs-4427	515	7	1–27	1–27	NOUN
gs-4427	515	8	.	.	PUNCT
gs-4427	515	9	https://doi.org/10.52340/gs.2025.07.04.01	https://doi.org/10.52340/gs.2025.07.04.01	PROPN
gs-4427	515	10	48	48	NUM
gs-4427	515	11	.	.	PUNCT
gs-4427	516	1	gorovits	gorovits	PROPN
gs-4427	516	2	b	b	PROPN
gs-4427	516	3	,	,	PUNCT
gs-4427	516	4	azadeh	azadeh	PROPN
gs-4427	516	5	m	m	PROPN
gs-4427	516	6	,	,	PUNCT
gs-4427	516	7	buchlis	buchli	VERB
gs-4427	516	8	g	g	PROPN
gs-4427	516	9	,	,	PUNCT
gs-4427	516	10	et	et	PROPN
gs-4427	516	11	al	al	PROPN
gs-4427	516	12	.	.	PUNCT
gs-4427	516	13	evaluation	evaluation	NOUN
gs-4427	516	14	of	of	ADP
gs-4427	516	15	cellular	cellular	ADJ
gs-4427	516	16	immune	immune	ADJ
gs-4427	516	17	response	response	NOUN
gs-4427	516	18	to	to	ADP
gs-4427	516	19	adeno	adeno	NOUN
gs-4427	516	20	-	-	PUNCT
gs-4427	516	21	associated	associate	VERB
gs-4427	516	22	virus	virus	NOUN
gs-4427	516	23	-	-	PUNCT
gs-4427	516	24	based	base	VERB
gs-4427	516	25	gene	gene	NOUN
gs-4427	516	26	therapy	therapy	NOUN
gs-4427	516	27	.	.	PUNCT
gs-4427	517	1	aaps	aaps	PROPN
gs-4427	517	2	j.	j.	PROPN
gs-4427	517	3	2023;25(3):47	2023;25(3):47	PROPN
gs-4427	517	4	.	.	PROPN
gs-4427	517	5	49	49	NUM
gs-4427	517	6	.	.	PUNCT
gs-4427	518	1	mendell	mendell	PROPN
gs-4427	518	2	jr	jr	PROPN
gs-4427	518	3	,	,	PUNCT
gs-4427	518	4	al	al	PROPN
gs-4427	518	5	-	-	PUNCT
gs-4427	518	6	zaidy	zaidy	PROPN
gs-4427	518	7	sa	sa	PROPN
gs-4427	518	8	,	,	PUNCT
gs-4427	518	9	rodino	rodino	NOUN
gs-4427	518	10	-	-	PUNCT
gs-4427	518	11	klapac	klapac	NOUN
gs-4427	518	12	lr	lr	PROPN
gs-4427	518	13	,	,	PUNCT
gs-4427	518	14	et	et	PROPN
gs-4427	518	15	al	al	PROPN
gs-4427	518	16	.	.	PUNCT
gs-4427	519	1	current	current	ADJ
gs-4427	519	2	clinical	clinical	ADJ
gs-4427	519	3	applications	application	NOUN
gs-4427	519	4	of	of	ADP
gs-4427	519	5	in	in	ADP
gs-4427	519	6	vivo	vivo	ADJ
gs-4427	519	7	gene	gene	NOUN
gs-4427	519	8	therapy	therapy	NOUN
gs-4427	519	9	with	with	ADP
gs-4427	519	10	aavs	aavs	PROPN
gs-4427	519	11	.	.	PUNCT
gs-4427	520	1	mol	mol	ADP
gs-4427	520	2	ther	ther	ADV
gs-4427	520	3	.	.	PUNCT
gs-4427	521	1	2021;29(2):464–88	2021;29(2):464–88	NUM
gs-4427	521	2	.	.	PUNCT