Georgian Scientists/ . 4 N 3, 2022 274 Georgian Scientists Vol. 4 Issue 4, 2022 https://doi.org/10.52340/gs.2022.04.04.31 12-13 , , , , , - , 1 , , , , 2 , , , . 3 , , , . 4 , , , , 5 , , , 12-13 11 , . , (1,2,3). 12-13 11 , . 2 : 1) , (n=8); 2) , 10 , 1 , 5 ( 19 , 300) – n=8. ( 11 ). , , , , , , Georgian Scientists/ . 4 N 3, 2022 275 , , . . : , , , , , , (4-10). , , .), ( . ) (12,13). , , (14-18). , : , , , (15-18). , (14). 12-13 11 ( 10 , 1 , 5 . 19 , 300.) ( 11 ), . 12-13 (n=16), (12 , 22 , (16,17) Georgian Scientists/ . 4 N 3, 2022 276 ). ( 07:00-19:00 ). 2 : 1) , (n=8); 2) , 10 , 1 , 5 ( 19 , 300)- n-8. (19-22). 24 , (2%- ) Vivid I 10 MHz (20-21). . t . 250 . . 11 : , , , , ( 1,2). 12-13 . , . 11 . . Georgian Scientists/ . 4 N 3, 2022 277 n=8 24 345 (±9) 344 (±9) ( ) 1.3 (±0.1) 1.3 (±0.1) ( ) 1.3 (±0.1) 1.3 (±0.1) ( ) 414 (±22) 414 (±22) ( ) 154 (±9) 154 (±9) ( ) 257 (±16) 257 (±16) ( / ) 88.3 (±5.2) 88.3 (±5.2) (%) 61 (±1) 61 (±1 N1 - n=8 24 345 (±9) 297 (±8) ( ) 1.3 (±0.1) 1.7 (±0.4) ( ) 1.3 (±0.1) 1.6 (±0.2) ( ) 414 (±22) 428 (±17) ( ) 154 (±9) 95 (±11) ( ) 257 (±16) 330 (±14) ( / ) 88.3 (±5.2) 102.3 (±5.6) (%) 61 (±1) 79 (±1 Georgian Scientists/ . 4 N 3, 2022 278 N2 - : 1. Petit-Demouliere B, Chenu F, Bourin M. Forced swimming test in mice: a review of antidepressant activity. Psychopharmacology. (Berl) 2005; 177: 245–255. 2. David DJ, Renard CE, Jolliet P, Hascoet M, Bourin M. Antidepressant-like effects in various mice strains in the forced swimming test. Psychopharmacology (Berl) 2003; 166: 373–382. 3. Houser SR. When does spontaneous sarcoplasmic reticulum Ca2+ release cause a triggered arrhythmia? Cellular versus tissue requirements. Circ Res. 2000; 87: 725–7. 4. 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Monocyte chemoattractant protein-1 is upregulated in rats with volume-overload congestive heart failure. Circulation. 2000; 102: 1315-1322 Changes in cardiac function parameters in 12-13-week-old, high-intensity exercised, healthy white experimental rats Anzor Gogiberidze1, Ramaz Khetsuriani2, Manana Arabuli-Tchlikadze3, Nino Pruidze-Liparteliani4, Natalia Catherine Hargreaves5 1Department of Human Anatomy, TSMU, Tbilisi, Georgia, 2Head of the Department of Human Anatomy, TSMU, Tbilisi, Georgia, 3Associate professor of the Department of Human Anatomy, TSMU, Tbilisi, Georgia, 4Associate professor of the Department of Human Anatomy, TSMU, Tbilisi, Georgia 5Natalia Catherine Hargreaves –Department of Human Anatomy, TSMU, Tbilisi, Georgia Abstract The aim of the study was to evaluate cardiac functional parameters after 11 weeks of dosed, high- intensity exercises on a treadmill in 12-13-week-old healthy rats. In general, physical activity is the cheapest and safest method to reduce cardiovascular disease risk factors (1, 2, 3). Within the scope of Georgian Scientists/ . 4 N 3, 2022 280 our study, we subjected 12-13-week-old healthy male rats to high-intensity exercise on a treadmill for 11 weeks and then studied cardiac function parameters by echocardiography to assess the effects of exercise on the healthy heart. The rats were divided into 2 groups: 1) control group, which did not receive any execrise (n=8); 2) The study group performed 10 full rotations on the treadmill per day, with 1-minute active breaks in between, 5 days a week (treadmill speed 19m/min, incline 300) – n=8. Cardiac function parameters were assessed through transthoracic echocardiography twice (at the start of the study and after 11 weeks). Compared to the control group, there were changes in the functional parameters in terms of improvement in the rats of the study group, in particular, the ejection fraction, stroke volume, left ventricular wall thickness, end-diastolic volume increased, and on the contrary, the end-systolic volume decreased, compared to the data of non-trained rats of the same sex and age. The present study can be considered as another step forward in the study of functional changes of healthy heart developed on the background of high-intensity physical activity. Keywords: rat, ejection fraction, treadmill exercise, cardiomyocyte, heart